

      <110> Tang, Y. Tom
      	Wang, Jian-rui
        Wang, Zhiwei
        Zhang, Jie
        Ren, Feiyan
        Zhou, Ping
        Ma, Yunqing
        Ghosh, Malabika
        Xue, Aidong J.
        Asundi, Vinod
        Zhao, Qing A.
        Wang, Dunrui
        Goodrich, Ryle W.
        Chen, Rui-hong
        Wehrman, Tom
        Weng, Gezhi
        Xu, Chongjun
        Boyle, Bryan J
        Drmanac, Radoje T

      <120> Novel Nucleic Acids and 
        Polypeptides



      <130> 820/PCT

      <140> To Be Assigned
      <141> To Be Assigned

      <150> US 60/339,739
      <151> 2001-12-10

      <150> US 10/128,558
      <151> 2002-04-22

      <150> US 60/339,453
      <151> 2001-12-11

      <150> US 60/365,384
      <151> 2002-03-14

      <150> US 60/365,091
      <151> 2002-03-14

      <150> US 60/372,615
      <151> 2002-04-12

      <150> US 60/376,045
      <151> 2002-04-24

      <150> US 60/372,381
      <151> 2002-04-12

      <150> US 09/488,725
      <151> 2000-01-21      
      
      <150> US 09/552,317
      <151> 2000-04-25
      
      <150> PCT/US00/35017
      <151> 2000-12-22
  
      <150> US 09/491,404
      <151> 2000-01-25
      
      <150> PCT/US01/02623
      <151> 2001-01-25

      <150> US 09/496,914
      <151> 2000-02-03

      <150> US 09/560,875
      <151> 2000-04-27 

      <150> PCT/US01/03800
      <151> 2001-02-05

      <150> US 09/515,126
      <151> 2000-02-28

      <150> US 09/577,409
      <151> 2000-05-18
      
      <150> PCT/US01/04927
      <151> 2001-02-26

      <150> US 09/519,705
      <151> 2000-03-07

      <150> US 09/574,454
      <151> 2000-05-19

      <150> PCT/US01/04941
      <151> 2001-03-05

      <150> US 09/540,217
      <151> 2000-03-31

      <150> US 09/649,167
      <151> 2000-08-23

      <150> PCT/US01/08631
      <151> 2001-03-30

      <150> US 09/552,929
      <151> 2000-04-18

      <150> US 09/770,160
      <151> 2001-01-26

      <150> PCT/US01/08656
      <151> 2001-04-18

      <150> US 09/577,408
      <151> 2000-05-18

      <150> PCT/US01/14827
      <151> 2001-05-16

      <160> 3134

      <170> pt_FL_genes Version 6.0

      <210> 1
      <211> 2112
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (406)..(2112)

      <400> 1
 tacatcttcg ccaagaatgg catccccttc gagcttcgca cagtggagct gaccaaagct     60

 gggctgggca ggcaggccca ggggatattg gccgcggatc cctgcctgtc cccgctgctt    120

 tgcagccagc agcacagcga tgcctttgcc caggacctgc aggcccgcgc ccatggggat    180

 cagtacctgt catggcagca catggccctg cagagtagct gctgctgggc catgtggcag    240

 acggggtata ccaaaggtgc cacggatgca gtcggcatgc cagcccaggt actcatgaac    300

 acgggcacga gcctgcaggt cagatggata ccagtggtcc ggcgtctggt acttacagct    360

 cagataataa tccctgtgtt cctgggcgag tcagtgccac ccgag    atg ttg gcg     414
                                                      Met Leu Ala
                                                        1

 gcc act ttg gct gag ctg gac gga tgc ctg cag ctg ctc gag gac aag      462
 Ala Thr Leu Ala Glu Leu Asp Gly Cys Leu Gln Leu Leu Glu Asp Lys
       5                  10                  15

 ttc ctg cgg gac cag gcc ttc ctt act ggg ccc cgt atc tct gtg gct      510
 Phe Leu Arg Asp Gln Ala Phe Leu Thr Gly Pro Arg Ile Ser Val Ala
  20                  25                  30                  35

 ggc ttg gtg gca atc acg gag ctg agg cat gag agt gcc atg ggc cca      558
 Gly Leu Val Ala Ile Thr Glu Leu Arg His Glu Ser Ala Met Gly Pro
                  40                  45                  50

 tca gtg ctg gct gct gag tct ttg aaa gcg gac cca cgg tgg cag cat      606
 Ser Val Leu Ala Ala Glu Ser Leu Lys Ala Asp Pro Arg Trp Gln His
              55                  60                  65

 ggt gcc caa cac gtg gag gct gca gtg cgg gag gac ctc ttc cag gag      654
 Gly Ala Gln His Val Glu Ala Ala Val Arg Glu Asp Leu Phe Gln Glu
          70                  75                  80

 gcc ctc cca gct gtc ctg aag gcc aag gac ctg cct cca gta gaa cct      702
 Ala Leu Pro Ala Val Leu Lys Ala Lys Asp Leu Pro Pro Val Glu Pro
      85                  90                  95

 gct gtt aaa gag aat ctg aag acc tta atg cag ctt ttc ttg cta gct      750
 Ala Val Lys Glu Asn Leu Lys Thr Leu Met Gln Leu Phe Leu Leu Ala
 100                 105                 110                 115

 gtt tcc gtt cct ctg ccc gcc atg ccg ttc ctg gag ctg gac acg aat      798
 Val Ser Val Pro Leu Pro Ala Met Pro Phe Leu Glu Leu Asp Thr Asn
                 120                 125                 130

 ttg ccc gcc aac cga gtg ccc gcg ggg ctg gag aaa cga ctc tgc gcc      846
 Leu Pro Ala Asn Arg Val Pro Ala Gly Leu Glu Lys Arg Leu Cys Ala
             135                 140                 145

 gcc gct gcc tcc atc ctg ggc aaa cct gcg gac cgc gtg aac gtg acg      894
 Ala Ala Ala Ser Ile Leu Gly Lys Pro Ala Asp Arg Val Asn Val Thr
         150                 155                 160

 gta cgg ccg ggc ctg gcc atg gcg ctg agc ggg tcc acc gag ccc tgc      942
 Val Arg Pro Gly Leu Ala Met Ala Leu Ser Gly Ser Thr Glu Pro Cys
     165                 170                 175

 gcg cag ctg tcc atc tcc tcc atc ggc gta gtg ggc acc gcc gag gac      990
 Ala Gln Leu Ser Ile Ser Ser Ile Gly Val Val Gly Thr Ala Glu Asp
 180                 185                 190                 195

 aac cgc agc cac agc gcc cac ttc ttt gag ttt ctc acc aag gag cta     1038
 Asn Arg Ser His Ser Ala His Phe Phe Glu Phe Leu Thr Lys Glu Leu
                 200                 205                 210

 gcc ctg ggc cag gac cgg ttt gcc cag gat gga ggc agc ggc ggc gca     1086
 Ala Leu Gly Gln Asp Arg Phe Ala Gln Asp Gly Gly Ser Gly Gly Ala
             215                 220                 225

 gag tcg ttt ctc cag ccc cgc ggg cac tcg gtt ggc ggg caa att cgt     1134
 Glu Ser Phe Leu Gln Pro Arg Gly His Ser Val Gly Gly Gln Ile Arg
         230                 235                 240

 gtc cag ctc cag gaa cgg cat ggc ggg cag agg aac gga aac agc tct     1182
 Val Gln Leu Gln Glu Arg His Gly Gly Gln Arg Asn Gly Asn Ser Ser
     245                 250                 255

 ggc gga aga aaa gct ggg ggg cgc gtg tct acc tgt ttc atg ctg tct     1230
 Gly Gly Arg Lys Ala Gly Gly Arg Val Ser Thr Cys Phe Met Leu Ser
 260                 265                 270                 275

 cac aca cag ggt gcc acc cct gtg ctg ggc act ggg ggg tgg ggc ctg     1278
 His Thr Gln Gly Ala Thr Pro Val Leu Gly Thr Gly Gly Trp Gly Leu
                 280                 285                 290

 atc ccc tat ttc ccg gcg cgc cgg gat cct gcc aca gct gct gcc cac     1326
 Ile Pro Tyr Phe Pro Ala Arg Arg Asp Pro Ala Thr Ala Ala Ala His
             295                 300                 305

 acc gcg ctc agc gcc ttc act gcc atc ccc gct gtc ctt gcc gcc ccc     1374
 Thr Ala Leu Ser Ala Phe Thr Ala Ile Pro Ala Val Leu Ala Ala Pro
         310                 315                 320

 gcc atg ggc cta gag ctg ttt ctt gac ctg gtg tcc cag ccc agc cgc     1422
 Ala Met Gly Leu Glu Leu Phe Leu Asp Leu Val Ser Gln Pro Ser Arg
     325                 330                 335

 gcc gtc tac atc ttc gcc aag aag aat ggc atc ccc tta gag ctg cgc     1470
 Ala Val Tyr Ile Phe Ala Lys Lys Asn Gly Ile Pro Leu Glu Leu Arg
 340                 345                 350                 355

 acc gtg gat ttg gtc aaa ggg cag cac aag agc aag gag ttc ttg cag     1518
 Thr Val Asp Leu Val Lys Gly Gln His Lys Ser Lys Glu Phe Leu Gln
                 360                 365                 370

 atc aac agc ctg ggg aaa ctg ccg acg ctc aag gat ggt gat ttc atc     1566
 Ile Asn Ser Leu Gly Lys Leu Pro Thr Leu Lys Asp Gly Asp Phe Ile
             375                 380                 385

 ttg act gaa agc tcg gcc atc ctg att tac ctg agc tgt aag tac cag     1614
 Leu Thr Glu Ser Ser Ala Ile Leu Ile Tyr Leu Ser Cys Lys Tyr Gln
         390                 395                 400

 acg ccg gac cac tgg tat cca tct gac ctg cag gct cgt gcc cgt gtt     1662
 Thr Pro Asp His Trp Tyr Pro Ser Asp Leu Gln Ala Arg Ala Arg Val
     405                 410                 415

 cat gag tac ctg ggc tgg cat gcc gac tgc atc cgt ggc acc ttt ggt     1710
 His Glu Tyr Leu Gly Trp His Ala Asp Cys Ile Arg Gly Thr Phe Gly
 420                 425                 430                 435

 ata ccc ctg tgg gtc cag gtg ttg ggg ccc ctc att ggg gtc cag gtg     1758
 Ile Pro Leu Trp Val Gln Val Leu Gly Pro Leu Ile Gly Val Gln Val
                 440                 445                 450

 ccc gag gag aag gtg gaa cgc aac agg act gcc atg gac cag gcc ctg     1806
 Pro Glu Glu Lys Val Glu Arg Asn Arg Thr Ala Met Asp Gln Ala Leu
             455                 460                 465

 caa tgg ctg gag gac aag ttc ctg ggg gac agg ccc ttc ctc gct ggc     1854
 Gln Trp Leu Glu Asp Lys Phe Leu Gly Asp Arg Pro Phe Leu Ala Gly
         470                 475                 480

 cag cag gtg aca ctg gct gat ctc atg gcc ctg gag gag ctg atg cag     1902
 Gln Gln Val Thr Leu Ala Asp Leu Met Ala Leu Glu Glu Leu Met Gln
     485                 490                 495

 ccg gtg gct ctc ggc tat gaa ctg ttt gag gga cgg cca cga ctg gca     1950
 Pro Val Ala Leu Gly Tyr Glu Leu Phe Glu Gly Arg Pro Arg Leu Ala
 500                 505                 510                 515

 gca tgg cgt gga cga gtg gag gct ttc ctg ggt gct gag cta tgc cag     1998
 Ala Trp Arg Gly Arg Val Glu Ala Phe Leu Gly Ala Glu Leu Cys Gln
                 520                 525                 530

 gag gcc cac agc atc atc ttg agc atc ctg gaa cag gcg gcc aag aaa     2046
 Glu Ala His Ser Ile Ile Leu Ser Ile Leu Glu Gln Ala Ala Lys Lys
             535                 540                 545

 acc ctc cca aca ccc tca cca gag gcc tat cag gct atg ctg ctt cga     2094
 Thr Leu Pro Thr Pro Ser Pro Glu Ala Tyr Gln Ala Met Leu Leu Arg
         550                 555                 560

 atc gcc agg atc ccc tga                                             2112
 Ile Ala Arg Ile Pro 
     565





      <210> 2
      <211> 3009
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (4)..(3009)

      <400> 2
 ttc  atg gag cat gga gcg ctt ggc agc ctt ggg gaa cat gca gcg aaa      48
      Met Glu His Gly Ala Leu Gly Ser Leu Gly Glu His Ala Ala Lys
        1               5                  10                  15

 gtt gtg gga aag gta ctc aga caa gag caa gac ttt gta ata acc cac       96
 Val Val Gly Lys Val Leu Arg Gln Glu Gln Asp Phe Val Ile Thr His
                  20                  25                  30

 cac cag cgt ttg gtg ggt cct act gtg atg gag cag aaa cac aga tgc      144
 His Gln Arg Leu Val Gly Pro Thr Val Met Glu Gln Lys His Arg Cys
              35                  40                  45

 aag ttt gca atg aaa gaa att gtc caa ttc atg gca agt ggg cga ctt      192
 Lys Phe Ala Met Lys Glu Ile Val Gln Phe Met Ala Ser Gly Arg Leu
          50                  55                  60

 ggg cca gtt gga gtg cct gtt ctg tgt cat gtg gag gag gtg cca gac      240
 Gly Pro Val Gly Val Pro Val Leu Cys His Val Glu Glu Val Pro Asp
      65                  70                  75

 aga gaa caa ggg gct gct ccg acc ctg tgc ccc agt atg gag gaa gga      288
 Arg Glu Gln Gly Ala Ala Pro Thr Leu Cys Pro Ser Met Glu Glu Gly
  80                  85                  90                  95

 aat gcg aag gga gtg atg tcc aga gtg att ttt gca aca gtg acc ctt      336
 Asn Ala Lys Gly Val Met Ser Arg Val Ile Phe Ala Thr Val Thr Leu
                 100                 105                 110

 gcc caa gtg agt gtt gga aat acc cat ggt aac tgg agt cct tgg agt      384
 Ala Gln Val Ser Val Gly Asn Thr His Gly Asn Trp Ser Pro Trp Ser
             115                 120                 125

 ggc tgg gga aca tgc agc cgg acg tgt aac gga ggg cag atg cgg cgg      432
 Gly Trp Gly Thr Cys Ser Arg Thr Cys Asn Gly Gly Gln Met Arg Arg
         130                 135                 140

 tac cgc aca tgt gat aac cct cct ccc tcc aat ggg gga aga gct tgt      480
 Tyr Arg Thr Cys Asp Asn Pro Pro Pro Ser Asn Gly Gly Arg Ala Cys
     145                 150                 155

 ggg gga cca gac tcc cag atc cag agg tgc aac act gac atg tgt cct      528
 Gly Gly Pro Asp Ser Gln Ile Gln Arg Cys Asn Thr Asp Met Cys Pro
 160                 165                 170                 175

 gtg gat gga agt tgg gga agc tgg cat agt tgg agc cag tgc tct gcc      576
 Val Asp Gly Ser Trp Gly Ser Trp His Ser Trp Ser Gln Cys Ser Ala
                 180                 185                 190

 tcc tgt gga gga ggt gaa aag act cgg aag cgg ctg tgc gac cat cct      624
 Ser Cys Gly Gly Gly Glu Lys Thr Arg Lys Arg Leu Cys Asp His Pro
             195                 200                 205

 gtg cca gtt aaa ggt ggc cgt ccc tgt ccc gga gac act act cag gtg      672
 Val Pro Val Lys Gly Gly Arg Pro Cys Pro Gly Asp Thr Thr Gln Val
         210                 215                 220

 acc agg tgc aat gta caa gca tgt cca ggt ggg ccc cag cga gcc aga      720
 Thr Arg Cys Asn Val Gln Ala Cys Pro Gly Gly Pro Gln Arg Ala Arg
     225                 230                 235

 gga agt gtt att gga aat att aat gat gtt gaa ttt gga att gct ttc      768
 Gly Ser Val Ile Gly Asn Ile Asn Asp Val Glu Phe Gly Ile Ala Phe
 240                 245                 250                 255

 ctt aat gcc aca ata act gat agc cct aac tct gat act aga ata ata      816
 Leu Asn Ala Thr Ile Thr Asp Ser Pro Asn Ser Asp Thr Arg Ile Ile
                 260                 265                 270

 cgt gcc aaa att acc aat gta cct cgt agt ctt ggt tca gca atg aga      864
 Arg Ala Lys Ile Thr Asn Val Pro Arg Ser Leu Gly Ser Ala Met Arg
             275                 280                 285

 aag ata gtt tct att cta aat ccc att tat tgg aca aca gca aag gaa      912
 Lys Ile Val Ser Ile Leu Asn Pro Ile Tyr Trp Thr Thr Ala Lys Glu
         290                 295                 300

 ata gga gaa gca gtc aat ggc ttt acc ctc acc aat gca gtc ttc aaa      960
 Ile Gly Glu Ala Val Asn Gly Phe Thr Leu Thr Asn Ala Val Phe Lys
     305                 310                 315

 aga gaa act caa gtg gaa ttt gca act gga gaa atc ttg cag atg agt     1008
 Arg Glu Thr Gln Val Glu Phe Ala Thr Gly Glu Ile Leu Gln Met Ser
 320                 325                 330                 335

 cat att gcc cgg ggc ttg gat tcc gat ggt tct ttg ctg cta gat atc     1056
 His Ile Ala Arg Gly Leu Asp Ser Asp Gly Ser Leu Leu Leu Asp Ile
                 340                 345                 350

 gtt gtg agt ggc tat gtc cta cag ctt cag tca cct gct gaa gtc act     1104
 Val Val Ser Gly Tyr Val Leu Gln Leu Gln Ser Pro Ala Glu Val Thr
             355                 360                 365

 gta aag gat tac aca gag gac tac att caa aca ggt cct ggg cag ctg     1152
 Val Lys Asp Tyr Thr Glu Asp Tyr Ile Gln Thr Gly Pro Gly Gln Leu
         370                 375                 380

 tac gcc tac tca acc cgg ctg ttc acc att gat ggc atc agc atc cca     1200
 Tyr Ala Tyr Ser Thr Arg Leu Phe Thr Ile Asp Gly Ile Ser Ile Pro
     385                 390                 395

 tac aca tgg aac cac acc gtt ttc tat gat cag gca cag gga aga atg     1248
 Tyr Thr Trp Asn His Thr Val Phe Tyr Asp Gln Ala Gln Gly Arg Met
 400                 405                 410                 415

 cct ttc ttg gtt gaa aca ctt cat gca tcc tct gtg gaa tct gac tat     1296
 Pro Phe Leu Val Glu Thr Leu His Ala Ser Ser Val Glu Ser Asp Tyr
                 420                 425                 430

 aac cag ata gaa gag aca ctg ggt ttt aaa att cat gct tca ata tcc     1344
 Asn Gln Ile Glu Glu Thr Leu Gly Phe Lys Ile His Ala Ser Ile Ser
             435                 440                 445

 aaa gga gat cgc agt aat cag tgc ccc tcc ggg ttt acc tta gac tca     1392
 Lys Gly Asp Arg Ser Asn Gln Cys Pro Ser Gly Phe Thr Leu Asp Ser
         450                 455                 460

 gtt gga cct ttt tgt gct gat gag gat gaa tgt gca gca ggg aat ccc     1440
 Val Gly Pro Phe Cys Ala Asp Glu Asp Glu Cys Ala Ala Gly Asn Pro
     465                 470                 475

 tgc tcc cat agc tgc cac aat gcc atg ggg act tac tac tgc tcc tgc     1488
 Cys Ser His Ser Cys His Asn Ala Met Gly Thr Tyr Tyr Cys Ser Cys
 480                 485                 490                 495

 cct aaa ggc ctc acc ata gct gca gat gga aga act tgt caa gat att     1536
 Pro Lys Gly Leu Thr Ile Ala Ala Asp Gly Arg Thr Cys Gln Asp Ile
                 500                 505                 510

 gat gag tgt gct ttg ggt agg cat acc tgc cac gct ggt cag gac tgt     1584
 Asp Glu Cys Ala Leu Gly Arg His Thr Cys His Ala Gly Gln Asp Cys
             515                 520                 525

 gac aat acg att gga tct tat cgc tgt gtg gtc cgt tgt gga agt ggc     1632
 Asp Asn Thr Ile Gly Ser Tyr Arg Cys Val Val Arg Cys Gly Ser Gly
         530                 535                 540

 ttt cga aga acc tct gat ggg ctg agt tgt caa gat att aat gaa tgt     1680
 Phe Arg Arg Thr Ser Asp Gly Leu Ser Cys Gln Asp Ile Asn Glu Cys
     545                 550                 555

 caa gaa tcc agc ccc tgt cac cag cgc tgt ttc aat gcc ata gga agt     1728
 Gln Glu Ser Ser Pro Cys His Gln Arg Cys Phe Asn Ala Ile Gly Ser
 560                 565                 570                 575

 ttc cat tgt gga tgt gaa cct ggg tat cag ctc aaa ggc aga aaa tgc     1776
 Phe His Cys Gly Cys Glu Pro Gly Tyr Gln Leu Lys Gly Arg Lys Cys
                 580                 585                 590

 atg gat gtg aac gag tgt aga caa aat gta tgc aga cca gat cag cac     1824
 Met Asp Val Asn Glu Cys Arg Gln Asn Val Cys Arg Pro Asp Gln His
             595                 600                 605

 tgt aag aac acc cgt ggt ggc tat aag tgc att gat ctt tgt cca aat     1872
 Cys Lys Asn Thr Arg Gly Gly Tyr Lys Cys Ile Asp Leu Cys Pro Asn
         610                 615                 620

 gga atg acc aag gca gaa aat gga acc tgt att ggt gag tgt ctg gct     1920
 Gly Met Thr Lys Ala Glu Asn Gly Thr Cys Ile Gly Glu Cys Leu Ala
     625                 630                 635

 gtt tcc gtg act gag atc agt ttg ccg tca aca agt caa ata ttg atg     1968
 Val Ser Val Thr Glu Ile Ser Leu Pro Ser Thr Ser Gln Ile Leu Met
 640                 645                 650                 655

 aat gta aag atg gga ccc atc agt gca gat ata acc aga tat gtg aga     2016
 Asn Val Lys Met Gly Pro Ile Ser Ala Asp Ile Thr Arg Tyr Val Arg
                 660                 665                 670

 ata caa gag gca gct atc gtt gtg tat gcc caa gag gtt atc ggt ctc     2064
 Ile Gln Glu Ala Ala Ile Val Val Tyr Ala Gln Glu Val Ile Gly Leu
             675                 680                 685

 aag gag ttg gaa gac cct gca tgg tgc tcc aac acc ccc ggc agc ttc     2112
 Lys Glu Leu Glu Asp Pro Ala Trp Cys Ser Asn Thr Pro Gly Ser Phe
         690                 695                 700

 aag tgt atc tgt cca cca gga caa cat tta tta ggg gac ggg aaa tct     2160
 Lys Cys Ile Cys Pro Pro Gly Gln His Leu Leu Gly Asp Gly Lys Ser
     705                 710                 715

 tgc gct gga ttg gag agg ctg cca aat tat ggc act caa tac agt agc     2208
 Cys Ala Gly Leu Glu Arg Leu Pro Asn Tyr Gly Thr Gln Tyr Ser Ser
 720                 725                 730                 735

 tat aac ctt gca cgg ttc tcc cct gtg aga aac aac tat caa cct caa     2256
 Tyr Asn Leu Ala Arg Phe Ser Pro Val Arg Asn Asn Tyr Gln Pro Gln
                 740                 745                 750

 cag cat tac aga cag tac tca cat ctc tac agc tcc tac tca gag tat     2304
 Gln His Tyr Arg Gln Tyr Ser His Leu Tyr Ser Ser Tyr Ser Glu Tyr
             755                 760                 765

 aga aac agc aga aca tct ctc tcc agg act aga agg act att agg aaa     2352
 Arg Asn Ser Arg Thr Ser Leu Ser Arg Thr Arg Arg Thr Ile Arg Lys
         770                 775                 780

 act tgc cct gaa ggc tct gag gca agc cat gac aca tgt gta gat att     2400
 Thr Cys Pro Glu Gly Ser Glu Ala Ser His Asp Thr Cys Val Asp Ile
     785                 790                 795

 gat gaa tgt gaa aat aca gat gcc tgc cag cat gag tgt aag aat acc     2448
 Asp Glu Cys Glu Asn Thr Asp Ala Cys Gln His Glu Cys Lys Asn Thr
 800                 805                 810                 815

 ttt gga agt tat cag tgc atc tgc cca cct ggc tat caa ctc aca cac     2496
 Phe Gly Ser Tyr Gln Cys Ile Cys Pro Pro Gly Tyr Gln Leu Thr His
                 820                 825                 830

 aat gga aag aca tgc caa gat atc gat gaa tgt ctg gag cag aat gtg     2544
 Asn Gly Lys Thr Cys Gln Asp Ile Asp Glu Cys Leu Glu Gln Asn Val
             835                 840                 845

 cac tgt gga ccc aat cgc atg tgc ttc aac atg aga gga agc tac cag     2592
 His Cys Gly Pro Asn Arg Met Cys Phe Asn Met Arg Gly Ser Tyr Gln
         850                 855                 860

 tgc atc gat aca ccc tgt cca ccc aac tac caa cgg gat cct gtt tca     2640
 Cys Ile Asp Thr Pro Cys Pro Pro Asn Tyr Gln Arg Asp Pro Val Ser
     865                 870                 875

 ggg ttc tgc ctc aag aac tgt cca ccc aat gat ttg gaa tgt gcc ttg     2688
 Gly Phe Cys Leu Lys Asn Cys Pro Pro Asn Asp Leu Glu Cys Ala Leu
 880                 885                 890                 895

 agc cca tat gcc ttg gaa tac aaa ctc gtc tcc ctc cca ttt gga ata     2736
 Ser Pro Tyr Ala Leu Glu Tyr Lys Leu Val Ser Leu Pro Phe Gly Ile
                 900                 905                 910

 gcc acc aat caa gat tta atc cgg ctg gtt gca tac aca cag gat gga     2784
 Ala Thr Asn Gln Asp Leu Ile Arg Leu Val Ala Tyr Thr Gln Asp Gly
             915                 920                 925

 gtg atg cat ccc agg aca act ttc ctc atg gta gat gag gaa cag act     2832
 Val Met His Pro Arg Thr Thr Phe Leu Met Val Asp Glu Glu Gln Thr
         930                 935                 940

 gtt cct ttt gcc ttg agg gat gaa aac ctg aaa gga gtg gtg tat aca     2880
 Val Pro Phe Ala Leu Arg Asp Glu Asn Leu Lys Gly Val Val Tyr Thr
     945                 950                 955

 aca cga cca cta cga gaa gca gag acc tac cgc atg agg gtc cga gcc     2928
 Thr Arg Pro Leu Arg Glu Ala Glu Thr Tyr Arg Met Arg Val Arg Ala
 960                 965                 970                 975

 tca tcc tac agt gcc aat ggg acc att gaa tat cag acc aca ttc ata     2976
 Ser Ser Tyr Ser Ala Asn Gly Thr Ile Glu Tyr Gln Thr Thr Phe Ile
                 980                 985                 990

 gtt tat ata gct gtg tcc gcc tat cca tac taa                         3009
 Val Tyr Ile Ala Val Ser Ala Tyr Pro Tyr 
             995                1000





      <210> 3
      <211> 645
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (258)..(629)

      <400> 3
 ttaatgcagc ttttcttgct gtgagtgcgt gtcccacact tgctgagcca ctgaggggat     60

 gctgtgttgg tagaataaag acatggagct gtccgtctcc ttggttgaag agaagacata    120

 tctgcaaagg ctctggtcca cagttcctcc agatatcatg cctgcattcc ttttgtctcc    180

 taccccattc cattctagct tccatgtgac ctccccagct tttctccgcc agagctgttt    240

 ccgttcctct gcccgcc   atg ccg ttc cta gag ctg cac acg aat ttc ccc     290
                      Met Pro Phe Leu Glu Leu His Thr Asn Phe Pro
                        1               5                  10

 gcc aac cga gtg ccc gcg ggg ctg gag aaa cgg ctg tgc gcc gtc gct      338
 Ala Asn Arg Val Pro Ala Gly Leu Glu Lys Arg Leu Cys Ala Val Ala
              15                  20                  25

 gcc tcc atc ttg ggc aaa cct gca gac ctt gtg aac gtg acg gta cgg      386
 Ala Ser Ile Leu Gly Lys Pro Ala Asp Leu Val Asn Val Thr Val Arg
          30                  35                  40

 ccg ggc ctg gcc agg gcg ctg agc ggg tcc acc gag ccc tgc gcg cag      434
 Pro Gly Leu Ala Arg Ala Leu Ser Gly Ser Thr Glu Pro Cys Ala Gln
      45                  50                  55

 ctg tcc atc tcc tcc atc ggc gta gtg ggc acc gcc gag gac aac cgc      482
 Leu Ser Ile Ser Ser Ile Gly Val Val Gly Thr Ala Glu Asp Asn Arg
  60                  65                  70                  75

 agc cac agt gcc cac ttc ttt gag ttt ctc acc aag gag cta gcc ctg      530
 Ser His Ser Ala His Phe Phe Glu Phe Leu Thr Lys Glu Leu Ala Leu
                  80                  85                  90

 ggc cag gac cgg tgc gca ggg gta gta ggc ccg gaa tat tat tct aaa      578
 Gly Gln Asp Arg Cys Ala Gly Val Val Gly Pro Glu Tyr Tyr Ser Lys
              95                 100                 105

 aca caa tca gag tac tcc att cct gct aac agt tta aag cca aac acc      626
 Thr Gln Ser Glu Tyr Ser Ile Pro Ala Asn Ser Leu Lys Pro Asn Thr
         110                 115                 120

 tag gcaggccatt tatgtg                                                645
 






      <210> 4
      <211> 396
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (1)..(396)

      <400> 4
  atg ccg ttc cta gag ctg cac acg aat ttc ccc gcc aac cga gtg ccc      48
  Met Pro Phe Leu Glu Leu His Thr Asn Phe Pro Ala Asn Arg Val Pro
    1               5                  10                  15

 gcg ggg ctg gag aaa cgg ctg tgc gcc gtc gct gcc tcc atc ttg ggc       96
 Ala Gly Leu Glu Lys Arg Leu Cys Ala Val Ala Ala Ser Ile Leu Gly
              20                  25                  30

 aaa cct gca gac gtg agc gtg ggc cgg gca gca ctg ggc gag ggg aag      144
 Lys Pro Ala Asp Val Ser Val Gly Arg Ala Ala Leu Gly Glu Gly Lys
          35                  40                  45

 ttg ctt gtg aac gtg gcg gta cgg ccg ggc ctg gcc atg gcg ctg agc      192
 Leu Leu Val Asn Val Ala Val Arg Pro Gly Leu Ala Met Ala Leu Ser
      50                  55                  60

 ggg tcc acc gag ccc tgc gcg cag ctg tcc atc tcc tcc atc ggc gta      240
 Gly Ser Thr Glu Pro Cys Ala Gln Leu Ser Ile Ser Ser Ile Gly Val
  65                  70                  75                  80

 gtg ggc acc gcc gag gac aac cgc agc cac agc gcc cac ttc ttt gag      288
 Val Gly Thr Ala Glu Asp Asn Arg Ser His Ser Ala His Phe Phe Glu
                  85                  90                  95

 ttt ctc acc aag gag cta gcc ctg ggc cag gac cgg ata ctt atc cgc      336
 Phe Leu Thr Lys Glu Leu Ala Leu Gly Gln Asp Arg Ile Leu Ile Arg
             100                 105                 110

 ttt ttc ccc ttg gag tcc tgg cag att ggc aag ata ggg acg gtc atg      384
 Phe Phe Pro Leu Glu Ser Trp Gln Ile Gly Lys Ile Gly Thr Val Met
         115                 120                 125

 act ttt tta tga                                                      396
 Thr Phe Leu 
     130





      <210> 5
      <211> 2145
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (76)..(2145)

      <400> 5
 cacgaagcct tgaccccacc tgccttggcc gctctggagg gcgctcccac tgcccctcag     60

 gccagctcag gagcc atg ggg cgc tgg gcc tgg gtc ccc agc ccc tgg ccc     111
                  Met Gly Arg Trp Ala Trp Val Pro Ser Pro Trp Pro
                    1               5                  10

 cca ccg ggg ctg ggc ccc ttc ctc ctc ctc ctc ctg ctg ctg ctg ctg      159
 Pro Pro Gly Leu Gly Pro Phe Leu Leu Leu Leu Leu Leu Leu Leu Leu
          15                  20                  25

 ctg cca cgg ggg ttc cag ccc cag cct ggc ggg aac cgt acg gag tcc      207
 Leu Pro Arg Gly Phe Gln Pro Gln Pro Gly Gly Asn Arg Thr Glu Ser
      30                  35                  40

 cca gaa cct aat gcc aca gcg acc cct gcg atc ccc act atc ctg gtg      255
 Pro Glu Pro Asn Ala Thr Ala Thr Pro Ala Ile Pro Thr Ile Leu Val
  45                  50                  55                  60

 acc tct gtg acc tct gag acc cca gca aca agt gct cca gag gca gag      303
 Thr Ser Val Thr Ser Glu Thr Pro Ala Thr Ser Ala Pro Glu Ala Glu
                  65                  70                  75

 gga ccc caa agt ggg ggg ctc ccg ccc ccg ccc agg gca gtt ccc tcg      351
 Gly Pro Gln Ser Gly Gly Leu Pro Pro Pro Pro Arg Ala Val Pro Ser
              80                  85                  90

 agc agt agc ccc cag gcc caa gca ctc acc gag gac ggg agg ccc tgc      399
 Ser Ser Ser Pro Gln Ala Gln Ala Leu Thr Glu Asp Gly Arg Pro Cys
          95                 100                 105

 agg ttc ccc ttc cgc tac ggg ggc cgc atg ctg cat gcc tgc act tcg      447
 Arg Phe Pro Phe Arg Tyr Gly Gly Arg Met Leu His Ala Cys Thr Ser
     110                 115                 120

 gag ggc agt gca cac agg aag tgg tgt gcc aca act cac aac tac gac      495
 Glu Gly Ser Ala His Arg Lys Trp Cys Ala Thr Thr His Asn Tyr Asp
 125                 130                 135                 140

 cgg gac agg gcc tgg ggc tac tgt gtg gag gcc acc ccg cct cca ggg      543
 Arg Asp Arg Ala Trp Gly Tyr Cys Val Glu Ala Thr Pro Pro Pro Gly
                 145                 150                 155

 ggc cca gct gcc ctg gat ccc tgt gcc tcc ggc ccc tgc ctc aat gga      591
 Gly Pro Ala Ala Leu Asp Pro Cys Ala Ser Gly Pro Cys Leu Asn Gly
             160                 165                 170

 ggc tcc tgc tcc aat acc cag gac ccc cag tcc tat cac tgc agc tgc      639
 Gly Ser Cys Ser Asn Thr Gln Asp Pro Gln Ser Tyr His Cys Ser Cys
         175                 180                 185

 ccc cgg gcc ttc acc ggc aag gac tgc ggc aca gag aaa tgc ttt gat      687
 Pro Arg Ala Phe Thr Gly Lys Asp Cys Gly Thr Glu Lys Cys Phe Asp
     190                 195                 200

 gag acc cgc tac gag tac ctg gag ggg ggc gac cgc tgg gcc cgc gtg      735
 Glu Thr Arg Tyr Glu Tyr Leu Glu Gly Gly Asp Arg Trp Ala Arg Val
 205                 210                 215                 220

 cgc cag ggc cac gtg gaa cag tgc gag tgc ttc ggg ggc cgg acc tgg      783
 Arg Gln Gly His Val Glu Gln Cys Glu Cys Phe Gly Gly Arg Thr Trp
                 225                 230                 235

 tgc gaa ggc acc cga cat aca gct tgt ctg agc agc cct tgc ctg aac      831
 Cys Glu Gly Thr Arg His Thr Ala Cys Leu Ser Ser Pro Cys Leu Asn
             240                 245                 250

 ggg ggc acc tgc cac ctg atc gtg gcc acc ggg acc acc gtg tgt gcc      879
 Gly Gly Thr Cys His Leu Ile Val Ala Thr Gly Thr Thr Val Cys Ala
         255                 260                 265

 tgc cca cca ggc ttc gct gga cgg ctc tgc aac atc gag cct gat gag      927
 Cys Pro Pro Gly Phe Ala Gly Arg Leu Cys Asn Ile Glu Pro Asp Glu
     270                 275                 280

 cgc tgc ttc ttg ggg aac ggc act ggg tac cgt ggc gtg gcc agc acc      975
 Arg Cys Phe Leu Gly Asn Gly Thr Gly Tyr Arg Gly Val Ala Ser Thr
 285                 290                 295                 300

 tca gcc tcg ggc ctc agc tgc ctg gcc tgg aac tcc gat ctg ctc tac     1023
 Ser Ala Ser Gly Leu Ser Cys Leu Ala Trp Asn Ser Asp Leu Leu Tyr
                 305                 310                 315

 cag gag ctg cac gtg gac tcc gtg ggc gcc gcg gcc ctg ctg ggc ctg     1071
 Gln Glu Leu His Val Asp Ser Val Gly Ala Ala Ala Leu Leu Gly Leu
             320                 325                 330

 ggc ccc cat gcc tac tgc cgg aat ccg gac aat gac gag agg ccc tgg     1119
 Gly Pro His Ala Tyr Cys Arg Asn Pro Asp Asn Asp Glu Arg Pro Trp
         335                 340                 345

 tgc tac gtg gtg aag gac agc gcg ctc tcc tgg gag tac tgc cgc ctg     1167
 Cys Tyr Val Val Lys Asp Ser Ala Leu Ser Trp Glu Tyr Cys Arg Leu
     350                 355                 360

 gag gcc tgc gga ccc cgg cgg ggc cag ccc ggg gct ctc atg tgg ggg     1215
 Glu Ala Cys Gly Pro Arg Arg Gly Gln Pro Gly Ala Leu Met Trp Gly
 365                 370                 375                 380

 tct ctg act gtg ctg ggg ctg gct gtg ggg ttc cgg gct gct gag ggg     1263
 Ser Leu Thr Val Leu Gly Leu Ala Val Gly Phe Arg Ala Ala Glu Gly
                 385                 390                 395

 gcc aca aag gcc tcc gtg tgt cca gcc cct ctg gcc ctc aca gag cct     1311
 Ala Thr Lys Ala Ser Val Cys Pro Ala Pro Leu Ala Leu Thr Glu Pro
             400                 405                 410

 cgg gat cgg gca tca aac ccc att cta cag att tgg aaa ctg agg gca     1359
 Arg Asp Arg Ala Ser Asn Pro Ile Leu Gln Ile Trp Lys Leu Arg Ala
         415                 420                 425

 gag gcc tgc ggc agg agg cac aag aag agg acg ttc ctg cgg cca cgt     1407
 Glu Ala Cys Gly Arg Arg His Lys Lys Arg Thr Phe Leu Arg Pro Arg
     430                 435                 440

 atc atc ggc ggc tcc tcc tcg ctg ccc ggc tcg cac ccc tgg ctg gcc     1455
 Ile Ile Gly Gly Ser Ser Ser Leu Pro Gly Ser His Pro Trp Leu Ala
 445                 450                 455                 460

 gcc atc tac atc ggg gac agc ttc tgc gcc ggg agc ctg gtc cac acc     1503
 Ala Ile Tyr Ile Gly Asp Ser Phe Cys Ala Gly Ser Leu Val His Thr
                 465                 470                 475

 tgc tgg gtg gtg tcg gcc gcc cac tgc ttc tcc cac agg gac agc gtc     1551
 Cys Trp Val Val Ser Ala Ala His Cys Phe Ser His Arg Asp Ser Val
             480                 485                 490

 tcc gtg gtg ctg ggc cag cac ttc ttc aac cgc acg acg gac gtg acg     1599
 Ser Val Val Leu Gly Gln His Phe Phe Asn Arg Thr Thr Asp Val Thr
         495                 500                 505

 cag acc ttc ggc atc gag aag tac atc ccg tac acc ctg tac tcg gtg     1647
 Gln Thr Phe Gly Ile Glu Lys Tyr Ile Pro Tyr Thr Leu Tyr Ser Val
     510                 515                 520

 ttc aac ccc agc gac cac gac ctc gtc ctg atc cgg ctg aag aag aaa     1695
 Phe Asn Pro Ser Asp His Asp Leu Val Leu Ile Arg Leu Lys Lys Lys
 525                 530                 535                 540

 ggg gac cgc tgt gcc aca cgc tcg cag ttc gtg cag ccc atc tgc ctg     1743
 Gly Asp Arg Cys Ala Thr Arg Ser Gln Phe Val Gln Pro Ile Cys Leu
                 545                 550                 555

 ccc gag ccc ggc agc acc ttc ccc gca gga cac aag tgc cag att gcg     1791
 Pro Glu Pro Gly Ser Thr Phe Pro Ala Gly His Lys Cys Gln Ile Ala
             560                 565                 570

 ggc tgg ggc cac ttg gat gag aac gtg agc ggc tac tcc agc tcc ctg     1839
 Gly Trp Gly His Leu Asp Glu Asn Val Ser Gly Tyr Ser Ser Ser Leu
         575                 580                 585

 cgg gag gcc ctg gtc ccc ctg gtc gcc gac cac aag tgc agc agc cct     1887
 Arg Glu Ala Leu Val Pro Leu Val Ala Asp His Lys Cys Ser Ser Pro
     590                 595                 600

 gag gtc tac ggc gcc gac atc agc ccc aac atg ctc tgt gcc ggc tac     1935
 Glu Val Tyr Gly Ala Asp Ile Ser Pro Asn Met Leu Cys Ala Gly Tyr
 605                 610                 615                 620

 ttc gac tgc aag tcc gac gcc tgc cag ggg gac tca ggg ggg ccc ctg     1983
 Phe Asp Cys Lys Ser Asp Ala Cys Gln Gly Asp Ser Gly Gly Pro Leu
                 625                 630                 635

 gcc tgc gag aag aac ggc gtg gct tac ctc tac ggc atc atc agc tgg     2031
 Ala Cys Glu Lys Asn Gly Val Ala Tyr Leu Tyr Gly Ile Ile Ser Trp
             640                 645                 650

 ggt gac ggc tgc ggg cgg ctc cac aag ccg ggg gtc tac acc cgc gtg     2079
 Gly Asp Gly Cys Gly Arg Leu His Lys Pro Gly Val Tyr Thr Arg Val
         655                 660                 665

 gcc aac tat gtg gac tgg atc aac gac cag ata cgg cct ccc agg cgg     2127
 Ala Asn Tyr Val Asp Trp Ile Asn Asp Gln Ile Arg Pro Pro Arg Arg
     670                 675                 680

 ctt gtg gct ccc tcc tga                                             2145
 Leu Val Ala Pro Ser 
 685





      <210> 6
      <211> 5208
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (196)..(5208)

      <400> 6
 ctccaggtaa ctgaggatgc agtatttctg ggctctgctc agcccacagg tagaagaagc     60

 cataagctgc gtgttcctgc ccaccaggag atcaccagtg gtgggatgac aggcacccct    120

 gttgcagtca tcttgagctt ttgagtaact gagccaccct tgaacacaac agaaatagct    180

 tacacggaag gcagt atg ccc cgt ttg ctg cct gaa cct ctc cac aaa gac     231
                  Met Pro Arg Leu Leu Pro Glu Pro Leu His Lys Asp
                    1               5                  10

 tcc cag atc ctg act gcc ttc cgt gta agc tat ttc tgt tgt gtt caa      279
 Ser Gln Ile Leu Thr Ala Phe Arg Val Ser Tyr Phe Cys Cys Val Gln
          15                  20                  25

 ggg tgg ctc agt tac tca aaa gct caa gat gac tgc aac agg ggt gcc      327
 Gly Trp Leu Ser Tyr Ser Lys Ala Gln Asp Asp Cys Asn Arg Gly Ala
      30                  35                  40

 tgt cat ccc acc act ggt gat ctc ctg gtg ggc agg aac acg cag ctt      375
 Cys His Pro Thr Thr Gly Asp Leu Leu Val Gly Arg Asn Thr Gln Leu
  45                  50                  55                  60

 atg gct tct tct acc tgt ggg ctg agc aga gcc cag aaa tac tgc atc      423
 Met Ala Ser Ser Thr Cys Gly Leu Ser Arg Ala Gln Lys Tyr Cys Ile
                  65                  70                  75

 ctc agt tac ctg gag ggg gaa caa aaa tgc ttc atc tgt gac tct aga      471
 Leu Ser Tyr Leu Glu Gly Glu Gln Lys Cys Phe Ile Cys Asp Ser Arg
              80                  85                  90

 ttt cca tat gat ccg tat gac caa ccc aac agc cac acc att gag aat      519
 Phe Pro Tyr Asp Pro Tyr Asp Gln Pro Asn Ser His Thr Ile Glu Asn
          95                 100                 105

 gtc att gta agt ttt gaa cca gac aga gaa aag aaa tgg tgg caa tct      567
 Val Ile Val Ser Phe Glu Pro Asp Arg Glu Lys Lys Trp Trp Gln Ser
     110                 115                 120

 gaa aat ggt ctt gat cat gtc agc atc aga ctg gac tta gag gca tta      615
 Glu Asn Gly Leu Asp His Val Ser Ile Arg Leu Asp Leu Glu Ala Leu
 125                 130                 135                 140

 ttt cgg ttc agc cac ctt atc ctg acc ttt aag act ttt cgg cct gct      663
 Phe Arg Phe Ser His Leu Ile Leu Thr Phe Lys Thr Phe Arg Pro Ala
                 145                 150                 155

 gca atg tta gtt gaa cgt tcc aca gac tat gga cac aac tgg aaa gtg      711
 Ala Met Leu Val Glu Arg Ser Thr Asp Tyr Gly His Asn Trp Lys Val
             160                 165                 170

 ttc aaa tat ttt gca aaa gac tgt gcc act tcc ttt cct aac atc aca      759
 Phe Lys Tyr Phe Ala Lys Asp Cys Ala Thr Ser Phe Pro Asn Ile Thr
         175                 180                 185

 tct ggc cag gcc cag gga gtg gga gac att gtt tgt gac tcc aaa tac      807
 Ser Gly Gln Ala Gln Gly Val Gly Asp Ile Val Cys Asp Ser Lys Tyr
     190                 195                 200

 tcg gat att gaa ccc tca aca ggt gga gag gtt gtt tta aaa gtt ttg      855
 Ser Asp Ile Glu Pro Ser Thr Gly Gly Glu Val Val Leu Lys Val Leu
 205                 210                 215                 220

 gat ccc agt ttt gaa att gaa aac cct tat agc ccc tac atc caa gac      903
 Asp Pro Ser Phe Glu Ile Glu Asn Pro Tyr Ser Pro Tyr Ile Gln Asp
                 225                 230                 235

 ctt gtg aca ttg aca aac ctg agg ata aac ttt acc aag ctc cac acc      951
 Leu Val Thr Leu Thr Asn Leu Arg Ile Asn Phe Thr Lys Leu His Thr
             240                 245                 250

 ctt ggg gat gct ttg ctt gga agg agg caa aat gat tcc ctt gat aaa      999
 Leu Gly Asp Ala Leu Leu Gly Arg Arg Gln Asn Asp Ser Leu Asp Lys
         255                 260                 265

 tac tac tat gct ctg tac gag atg att gtt cgg gga agc tgc ttt tgc     1047
 Tyr Tyr Tyr Ala Leu Tyr Glu Met Ile Val Arg Gly Ser Cys Phe Cys
     270                 275                 280

 aat ggc cat gct agc gaa tgt cgc cct atg cag aag atg cgg gga gat     1095
 Asn Gly His Ala Ser Glu Cys Arg Pro Met Gln Lys Met Arg Gly Asp
 285                 290                 295                 300

 gtt ttc agc cct cct gga atg gtt cac ggt cag tgt gtg tgt cag cac     1143
 Val Phe Ser Pro Pro Gly Met Val His Gly Gln Cys Val Cys Gln His
                 305                 310                 315

 aat aca gat ggt ccg aac tgt gag aga tgc aag gac ttc ttc cag gat     1191
 Asn Thr Asp Gly Pro Asn Cys Glu Arg Cys Lys Asp Phe Phe Gln Asp
             320                 325                 330

 gct cct tgg agg cca gct gca gac ctc cag gac aac gct tgc aga tcg     1239
 Ala Pro Trp Arg Pro Ala Ala Asp Leu Gln Asp Asn Ala Cys Arg Ser
         335                 340                 345

 tgc agc tgt aat agc cac tcc agc cgc tgt cac ttt gac atg act acg     1287
 Cys Ser Cys Asn Ser His Ser Ser Arg Cys His Phe Asp Met Thr Thr
     350                 355                 360

 tac ctg gca agc ggt ggc ctc agc ggg ggc gtg tgt gaa gac tgc cag     1335
 Tyr Leu Ala Ser Gly Gly Leu Ser Gly Gly Val Cys Glu Asp Cys Gln
 365                 370                 375                 380

 cac aac act gag ggg cag cac tgc gac cgc tgc aga ccc ctc ttc tac     1383
 His Asn Thr Glu Gly Gln His Cys Asp Arg Cys Arg Pro Leu Phe Tyr
                 385                 390                 395

 agg gac ccg ctc aag acc atc tca gat ccc tac gcg tgc att cct tgt     1431
 Arg Asp Pro Leu Lys Thr Ile Ser Asp Pro Tyr Ala Cys Ile Pro Cys
             400                 405                 410

 gaa tgt gac ccc gat ggg acc ata tct ggt ggc att tgt gtg agc cac     1479
 Glu Cys Asp Pro Asp Gly Thr Ile Ser Gly Gly Ile Cys Val Ser His
         415                 420                 425

 tct gat cct gcc tta ggg tct gtg gcc ggc cag tgc ctt tgt aaa gag     1527
 Ser Asp Pro Ala Leu Gly Ser Val Ala Gly Gln Cys Leu Cys Lys Glu
     430                 435                 440

 aac gtg gaa gga gcc aaa tgc gac cag tgc aaa ccc aac cac tac gga     1575
 Asn Val Glu Gly Ala Lys Cys Asp Gln Cys Lys Pro Asn His Tyr Gly
 445                 450                 455                 460

 cta agc gcc acc gac ccc ctg ggc tgc cag ccc tgc gac tgt aac ccc     1623
 Leu Ser Ala Thr Asp Pro Leu Gly Cys Gln Pro Cys Asp Cys Asn Pro
                 465                 470                 475

 ctt ggg agt ctg cca ttc ttg acc tgt gat gtg gat aca ggc caa tgc     1671
 Leu Gly Ser Leu Pro Phe Leu Thr Cys Asp Val Asp Thr Gly Gln Cys
             480                 485                 490

 ttg tgc ctg tca tat gtc acc gga gca cac tgc gaa gaa tgc act gtt     1719
 Leu Cys Leu Ser Tyr Val Thr Gly Ala His Cys Glu Glu Cys Thr Val
         495                 500                 505

 gga tac tgg ggc ctg gga aat cat ctc cat ggg tgt tct ccc tgt gac     1767
 Gly Tyr Trp Gly Leu Gly Asn His Leu His Gly Cys Ser Pro Cys Asp
     510                 515                 520

 tgt gat att gga ggt gct tat tct aac gtg tgc tca ccc aag aat ggg     1815
 Cys Asp Ile Gly Gly Ala Tyr Ser Asn Val Cys Ser Pro Lys Asn Gly
 525                 530                 535                 540

 cag tgt gaa tgc cgc cca cat gtc act ggc cgt agc tgc tct gaa cca     1863
 Gln Cys Glu Cys Arg Pro His Val Thr Gly Arg Ser Cys Ser Glu Pro
                 545                 550                 555

 gcc cct ggc tac ttc ttt gct cct ttg aat ttc tat ctc tac gag gca     1911
 Ala Pro Gly Tyr Phe Phe Ala Pro Leu Asn Phe Tyr Leu Tyr Glu Ala
             560                 565                 570

 gag gaa gcc aca aca ctc caa gga ctg gcg cct ttg ggc tcg gag acg     1959
 Glu Glu Ala Thr Thr Leu Gln Gly Leu Ala Pro Leu Gly Ser Glu Thr
         575                 580                 585

 ttt ggc cag agt cct gct gtt cac gtt gtt tta gga gag cca gtt cct     2007
 Phe Gly Gln Ser Pro Ala Val His Val Val Leu Gly Glu Pro Val Pro
     590                 595                 600

 ggg aac cct gtt aca tgg act gga cct gga ttt gcc agg gtt ctc cct     2055
 Gly Asn Pro Val Thr Trp Thr Gly Pro Gly Phe Ala Arg Val Leu Pro
 605                 610                 615                 620

 ggg gct ggc ttg aga ttt gct gtc aac aac att ccc ttt cct gtg gac     2103
 Gly Ala Gly Leu Arg Phe Ala Val Asn Asn Ile Pro Phe Pro Val Asp
                 625                 630                 635

 ttc acc att gcc att cac tat gaa acc cag tct gca gct gac tgg act     2151
 Phe Thr Ile Ala Ile His Tyr Glu Thr Gln Ser Ala Ala Asp Trp Thr
             640                 645                 650

 gtc cag att gtg gtg aac ccc cct gga ggg agt gag cac tgc ata ccc     2199
 Val Gln Ile Val Val Asn Pro Pro Gly Gly Ser Glu His Cys Ile Pro
         655                 660                 665

 aag act cta cag tca aag cct cag tct ttt gcc tta cca gcg gct acg     2247
 Lys Thr Leu Gln Ser Lys Pro Gln Ser Phe Ala Leu Pro Ala Ala Thr
     670                 675                 680

 aga atc atg ctg ctt ccc aca ccc atc tgt tta gaa cca gat gta caa     2295
 Arg Ile Met Leu Leu Pro Thr Pro Ile Cys Leu Glu Pro Asp Val Gln
 685                 690                 695                 700

 tat tcc ata gat gtc tat ttt tct cag cct ttg caa gga gag tcc cac     2343
 Tyr Ser Ile Asp Val Tyr Phe Ser Gln Pro Leu Gln Gly Glu Ser His
                 705                 710                 715

 gct cat tca cat gtc ctg gtg gac tct ctt ggc ctt att ccc caa atc     2391
 Ala His Ser His Val Leu Val Asp Ser Leu Gly Leu Ile Pro Gln Ile
             720                 725                 730

 aat tca ttg gag aat ttc tgc agc aag cag gac tta gat gag tat cag     2439
 Asn Ser Leu Glu Asn Phe Cys Ser Lys Gln Asp Leu Asp Glu Tyr Gln
         735                 740                 745

 ctt cac aac tgt gtt gaa att gcc tca gca atg gga cct caa gtg ctc     2487
 Leu His Asn Cys Val Glu Ile Ala Ser Ala Met Gly Pro Gln Val Leu
     750                 755                 760

 ccg ggt gcc tgt gaa agg ctg atc atc agc atg tct gcc aag ctg cat     2535
 Pro Gly Ala Cys Glu Arg Leu Ile Ile Ser Met Ser Ala Lys Leu His
 765                 770                 775                 780

 gat ggg gct gtg gcc tgc aag tgt cac ccc cag ggc tca gtc gga tcc     2583
 Asp Gly Ala Val Ala Cys Lys Cys His Pro Gln Gly Ser Val Gly Ser
                 785                 790                 795

 agc tgc agc cga ctt gga ggc cag tgc cag tgt aaa cct ctt gtg gtc     2631
 Ser Cys Ser Arg Leu Gly Gly Gln Cys Gln Cys Lys Pro Leu Val Val
             800                 805                 810

 ggg cgc tgc tgt gac agg tgc tca act gga agc tat gat ttg ggg cat     2679
 Gly Arg Cys Cys Asp Arg Cys Ser Thr Gly Ser Tyr Asp Leu Gly His
         815                 820                 825

 cac ggc tgt cac cca tgt cac tgc cat cct caa gga tca aag gac act     2727
 His Gly Cys His Pro Cys His Cys His Pro Gln Gly Ser Lys Asp Thr
     830                 835                 840

 gta tgt gac caa gta aca gga cag tgc ccc tgc cat gga gag gtg tct     2775
 Val Cys Asp Gln Val Thr Gly Gln Cys Pro Cys His Gly Glu Val Ser
 845                 850                 855                 860

 ggc cgc cgc tgt gat cgc tgc ctg gca ggc tac ttt gga ttt ccc agc     2823
 Gly Arg Arg Cys Asp Arg Cys Leu Ala Gly Tyr Phe Gly Phe Pro Ser
                 865                 870                 875

 tgc cac cct tgc cct tgt aat agg ttt gct gaa ctt tgt gat cct gag     2871
 Cys His Pro Cys Pro Cys Asn Arg Phe Ala Glu Leu Cys Asp Pro Glu
             880                 885                 890

 aca ggg tca tgc ttc aat tgt gga ggc ttt aca act ggc aga aac tgt     2919
 Thr Gly Ser Cys Phe Asn Cys Gly Gly Phe Thr Thr Gly Arg Asn Cys
         895                 900                 905

 gaa agg tgt att gat ggt tac tat gga aat cct tct tca gga cag ccc     2967
 Glu Arg Cys Ile Asp Gly Tyr Tyr Gly Asn Pro Ser Ser Gly Gln Pro
     910                 915                 920

 tgt cgt cct tgc ctg tgt cca gat gat ccc tca agc aat cag tat ttt     3015
 Cys Arg Pro Cys Leu Cys Pro Asp Asp Pro Ser Ser Asn Gln Tyr Phe
 925                 930                 935                 940

 gcc cat tcc tgt tat cag aat ctg tgg agc tca gat gta atc tgc aat     3063
 Ala His Ser Cys Tyr Gln Asn Leu Trp Ser Ser Asp Val Ile Cys Asn
                 945                 950                 955

 tgt ctt caa ggt tat acg ggt act cag tgt gga gaa tgc tct act ggt     3111
 Cys Leu Gln Gly Tyr Thr Gly Thr Gln Cys Gly Glu Cys Ser Thr Gly
             960                 965                 970

 ttc tat gga aat cca aga att tca gga gca cct tgc caa cca tgt gcc     3159
 Phe Tyr Gly Asn Pro Arg Ile Ser Gly Ala Pro Cys Gln Pro Cys Ala
         975                 980                 985

 tgc aac aac aac ata gat gta acc gat cca gag tcc tgc agc cgg gta     3207
 Cys Asn Asn Asn Ile Asp Val Thr Asp Pro Glu Ser Cys Ser Arg Val
     990                 995                1000

 aca ggg gag tgc ctt cga tgt ttg cac aac act cag ggc gca aac tgc     3255
 Thr Gly Glu Cys Leu Arg Cys Leu His Asn Thr Gln Gly Ala Asn Cys
1005                1010                1015                1020

 cag ctc tgc aaa cca ggt cac tat gga tca gcc ctc aat cag acc tgc     3303
 Gln Leu Cys Lys Pro Gly His Tyr Gly Ser Ala Leu Asn Gln Thr Cys
                1025                1030                1035

 aga aga tgc tcc tgc cat gct tcc ggc gtg agt ccc atg gag tgt ccc     3351
 Arg Arg Cys Ser Cys His Ala Ser Gly Val Ser Pro Met Glu Cys Pro
            1040                1045                1050

 cct ggt ggg gga gct tgc ctc tgt gac cct gtc act ggt gca tgt cct     3399
 Pro Gly Gly Gly Ala Cys Leu Cys Asp Pro Val Thr Gly Ala Cys Pro
        1055                1060                1065

 tgt ctg ccg aat gtc aca ggc ctg gcc tgt gac cgt tgt gct gat gga     3447
 Cys Leu Pro Asn Val Thr Gly Leu Ala Cys Asp Arg Cys Ala Asp Gly
    1070                1075                1080

 tac tgg aat ctg gtc cct ggc aga gga tca tgt gat tgt aac agg gca     3495
 Tyr Trp Asn Leu Val Pro Gly Arg Gly Ser Cys Asp Cys Asn Arg Ala
1085                1090                1095                1100

 ggt acc cag aag ccc atc tgt gat cca gac aca ggc atg tgc cgc tgc     3543
 Gly Thr Gln Lys Pro Ile Cys Asp Pro Asp Thr Gly Met Cys Arg Cys
                1105                1110                1115

 cgg gag ggt gtc agc ggc cag aga tgt gat cgc tgt gcc cgg gga cac     3591
 Arg Glu Gly Val Ser Gly Gln Arg Cys Asp Arg Cys Ala Arg Gly His
            1120                1125                1130

 agc cag gaa ttc cct act tgt ctt caa tgt cac ttg tgc ttt gat cag     3639
 Ser Gln Glu Phe Pro Thr Cys Leu Gln Cys His Leu Cys Phe Asp Gln
        1135                1140                1145

 tgg gac cac acc att tct tcc ctc tcc aaa gcg gtg caa ggg tta atg     3687
 Trp Asp His Thr Ile Ser Ser Leu Ser Lys Ala Val Gln Gly Leu Met
    1150                1155                1160

 aga ctg gct gct aac atg gaa gat aaa aga gag acc ctg cct gtc tgt     3735
 Arg Leu Ala Ala Asn Met Glu Asp Lys Arg Glu Thr Leu Pro Val Cys
1165                1170                1175                1180

 gag gca gac ttc aaa gac ctc aga ggg aac gtg tct gaa ata gaa agg     3783
 Glu Ala Asp Phe Lys Asp Leu Arg Gly Asn Val Ser Glu Ile Glu Arg
                1185                1190                1195

 att ttg aaa cat cct gtt ttc cca tct ggg aaa ttc tta aaa gtc aag     3831
 Ile Leu Lys His Pro Val Phe Pro Ser Gly Lys Phe Leu Lys Val Lys
            1200                1205                1210

 gat tat cat gac tct gtt aga aga caa atc atg cag cta aat gaa caa     3879
 Asp Tyr His Asp Ser Val Arg Arg Gln Ile Met Gln Leu Asn Glu Gln
        1215                1220                1225

 ctg aaa gca gtg tat gaa ttt caa gat ctg aaa gat aca ata gaa aga     3927
 Leu Lys Ala Val Tyr Glu Phe Gln Asp Leu Lys Asp Thr Ile Glu Arg
    1230                1235                1240

 gca aag aat gaa gca gac ctc tta ctt gaa gac ctt cag gaa gaa att     3975
 Ala Lys Asn Glu Ala Asp Leu Leu Leu Glu Asp Leu Gln Glu Glu Ile
1245                1250                1255                1260

 gat ttg caa tcc agt gtc ctt aat gca agc att gcg gac tcc tca gaa     4023
 Asp Leu Gln Ser Ser Val Leu Asn Ala Ser Ile Ala Asp Ser Ser Glu
                1265                1270                1275

 aac atc aag aaa tat tat cac ata tca tca tct gct gaa aag aaa att     4071
 Asn Ile Lys Lys Tyr Tyr His Ile Ser Ser Ser Ala Glu Lys Lys Ile
            1280                1285                1290

 aat gaa act agt tcc acc att aat acc tct gca aat aca agg aat gac     4119
 Asn Glu Thr Ser Ser Thr Ile Asn Thr Ser Ala Asn Thr Arg Asn Asp
        1295                1300                1305

 tta ctt acc atc tta gat aca cta acc tca aaa gga aac ttg tca ttg     4167
 Leu Leu Thr Ile Leu Asp Thr Leu Thr Ser Lys Gly Asn Leu Ser Leu
    1310                1315                1320

 gaa aga tta aag cag att aag ata cca gat atc caa ata ttg aat gaa     4215
 Glu Arg Leu Lys Gln Ile Lys Ile Pro Asp Ile Gln Ile Leu Asn Glu
1325                1330                1335                1340

 aag gtg tgc gga gat cca gga aat gtg cca tgt gtg ccc ttg ccc tgt     4263
 Lys Val Cys Gly Asp Pro Gly Asn Val Pro Cys Val Pro Leu Pro Cys
                1345                1350                1355

 ggc ggt gct ctc tgc acg ggc cgg aag ggg cac agg aag tgt agg ggt     4311
 Gly Gly Ala Leu Cys Thr Gly Arg Lys Gly His Arg Lys Cys Arg Gly
            1360                1365                1370

 ccc ggc tgt cac ggc tcc ctg acc ctc tca acg aat gcc ctc caa aaa     4359
 Pro Gly Cys His Gly Ser Leu Thr Leu Ser Thr Asn Ala Leu Gln Lys
        1375                1380                1385

 gcc cag gaa gca aaa tcc att att cgt aat ttg gac aaa cag gtt cgt     4407
 Ala Gln Glu Ala Lys Ser Ile Ile Arg Asn Leu Asp Lys Gln Val Arg
    1390                1395                1400

 ggg ttg aaa aat cag atc gaa agt ata agt gaa cag gca gaa gtc tcc     4455
 Gly Leu Lys Asn Gln Ile Glu Ser Ile Ser Glu Gln Ala Glu Val Ser
1405                1410                1415                1420

 aaa aac aat gcc tta cag ctg agg gaa aaa ctg gga aat ata aga aac     4503
 Lys Asn Asn Ala Leu Gln Leu Arg Glu Lys Leu Gly Asn Ile Arg Asn
                1425                1430                1435

 caa agt gac tct gaa gaa gaa aac atc aat ctt ttc atc aaa aaa gtg     4551
 Gln Ser Asp Ser Glu Glu Glu Asn Ile Asn Leu Phe Ile Lys Lys Val
            1440                1445                1450

 aaa aac ttt ttg tta gag gaa aac gtg cct cca gaa gac atc gag aag     4599
 Lys Asn Phe Leu Leu Glu Glu Asn Val Pro Pro Glu Asp Ile Glu Lys
        1455                1460                1465

 gtt gcg aat ggt gtg ctt gac att cac cta cca att cca tcc caa aat     4647
 Val Ala Asn Gly Val Leu Asp Ile His Leu Pro Ile Pro Ser Gln Asn
    1470                1475                1480

 cta acc gat gaa ctt gtc aaa ata cag aaa cat atg caa ctc tgt gag     4695
 Leu Thr Asp Glu Leu Val Lys Ile Gln Lys His Met Gln Leu Cys Glu
1485                1490                1495                1500

 gat tac agg aca gat gaa aac agg tta aat gaa gaa gca gat gga gcc     4743
 Asp Tyr Arg Thr Asp Glu Asn Arg Leu Asn Glu Glu Ala Asp Gly Ala
                1505                1510                1515

 caa aag ctt ttg gtg aag gcc aaa gca gct gag aaa gca gca aat att     4791
 Gln Lys Leu Leu Val Lys Ala Lys Ala Ala Glu Lys Ala Ala Asn Ile
            1520                1525                1530

 cta tta aat ctt gac aaa aca ttg aac cag tta caa caa gct caa atc     4839
 Leu Leu Asn Leu Asp Lys Thr Leu Asn Gln Leu Gln Gln Ala Gln Ile
        1535                1540                1545

 act caa gga cgg gca aac tct acc att aca cag ctg act gcc aat ata     4887
 Thr Gln Gly Arg Ala Asn Ser Thr Ile Thr Gln Leu Thr Ala Asn Ile
    1550                1555                1560

 aca aaa ata aaa aag aat gtg ctg cag gaa ttt gtt gag ctg aaa aaa     4935
 Thr Lys Ile Lys Lys Asn Val Leu Gln Glu Phe Val Glu Leu Lys Lys
1565                1570                1575                1580

 caa tat gct att ctc caa cgt aag aca agc act aca gga cta aca aag     4983
 Gln Tyr Ala Ile Leu Gln Arg Lys Thr Ser Thr Thr Gly Leu Thr Lys
                1585                1590                1595

 gag aca tta gga aaa gtt aaa cag cta aaa gat gcg gca gaa aaa ttg     5031
 Glu Thr Leu Gly Lys Val Lys Gln Leu Lys Asp Ala Ala Glu Lys Leu
            1600                1605                1610

 gct gga gat aca gag gcc aag ata aga aga ata aca gat tta gaa agg     5079
 Ala Gly Asp Thr Glu Ala Lys Ile Arg Arg Ile Thr Asp Leu Glu Arg
        1615                1620                1625

 aaa atc caa gat ttg aat cta agt aga caa gca aaa gct gat caa ctg     5127
 Lys Ile Gln Asp Leu Asn Leu Ser Arg Gln Ala Lys Ala Asp Gln Leu
    1630                1635                1640

 aga ata ttg gaa gat caa gtt gtt gcc att aaa aat gaa att gtt gaa     5175
 Arg Ile Leu Glu Asp Gln Val Val Ala Ile Lys Asn Glu Ile Val Glu
1645                1650                1655                1660

 caa gaa aaa aaa tat gct agg tgc tat agc tag                         5208
 Gln Glu Lys Lys Tyr Ala Arg Cys Tyr Ser 
                1665                1670





      <210> 7
      <211> 2694
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (1)..(2694)

      <400> 7
  atg ggc tcg ggg cgc gta ccc ggg ctc tgc ctg ctt gtc ctg ctg gtc      48
  Met Gly Ser Gly Arg Val Pro Gly Leu Cys Leu Leu Val Leu Leu Val
    1               5                  10                  15

 cac gcc cgc gcc gcc cag tac agc aaa gcc gcg caa gat gtg gat gag       96
 His Ala Arg Ala Ala Gln Tyr Ser Lys Ala Ala Gln Asp Val Asp Glu
              20                  25                  30

 tgt gtg gag ggg act gac aac tgc cac atc gat gct atc tgc cag aac      144
 Cys Val Glu Gly Thr Asp Asn Cys His Ile Asp Ala Ile Cys Gln Asn
          35                  40                  45

 acc ccg agg tca tac aag tgc atc tgc aag tct ggc tac aca ggg gac      192
 Thr Pro Arg Ser Tyr Lys Cys Ile Cys Lys Ser Gly Tyr Thr Gly Asp
      50                  55                  60

 ggc aaa cac tgc aaa gac gtg gat gag tgc gag cga gag gat aat gca      240
 Gly Lys His Cys Lys Asp Val Asp Glu Cys Glu Arg Glu Asp Asn Ala
  65                  70                  75                  80

 ggt tgt gtg cat gac tgt gtc aac atc cct ggc aat tac cgg tgt acc      288
 Gly Cys Val His Asp Cys Val Asn Ile Pro Gly Asn Tyr Arg Cys Thr
                  85                  90                  95

 tgc tat gat gga ttc cac ctg gca cat gac gga cac aac tgt ctg gat      336
 Cys Tyr Asp Gly Phe His Leu Ala His Asp Gly His Asn Cys Leu Asp
             100                 105                 110

 gtg gac gag tgt gcc gag ggc aac ggc ggc tgt cag cag agc tgt gtc      384
 Val Asp Glu Cys Ala Glu Gly Asn Gly Gly Cys Gln Gln Ser Cys Val
         115                 120                 125

 aac atg atg ggc agc tat gag tgc cac tgc cgg gaa ggc ttc ttc ctc      432
 Asn Met Met Gly Ser Tyr Glu Cys His Cys Arg Glu Gly Phe Phe Leu
     130                 135                 140

 agc gac aac cag cat acc tgt atc cag cgg cca gaa gaa gga atg aat      480
 Ser Asp Asn Gln His Thr Cys Ile Gln Arg Pro Glu Glu Gly Met Asn
 145                 150                 155                 160

 tgc atg aac aag aac cac ggc tgt gcc cac att tgc cgg gag aca ccc      528
 Cys Met Asn Lys Asn His Gly Cys Ala His Ile Cys Arg Glu Thr Pro
                 165                 170                 175

 aag ggg ggt att gcc tgt gaa tgc cgt cct ggc ttt gag ctt acc aag      576
 Lys Gly Gly Ile Ala Cys Glu Cys Arg Pro Gly Phe Glu Leu Thr Lys
             180                 185                 190

 aac caa cgg gac tgt aaa tgt gag ata att ggg atg gca gtg aca tgc      624
 Asn Gln Arg Asp Cys Lys Cys Glu Ile Ile Gly Met Ala Val Thr Cys
         195                 200                 205

 aac tat ggt aac ggc ggc tgc cag cac acg tgt gat gac aca gag cag      672
 Asn Tyr Gly Asn Gly Gly Cys Gln His Thr Cys Asp Asp Thr Glu Gln
     210                 215                 220

 ggt ccc cgg tgc ggc tgc cat atc aag ttt gtg ctc cat acc gac ggg      720
 Gly Pro Arg Cys Gly Cys His Ile Lys Phe Val Leu His Thr Asp Gly
 225                 230                 235                 240

 aag aca tgc atc gag acc tgt gct gtc aac aac ggg ggc tgt gac agt      768
 Lys Thr Cys Ile Glu Thr Cys Ala Val Asn Asn Gly Gly Cys Asp Ser
                 245                 250                 255

 aag tgc cat gat gca gcg act ggt gtc cac tgc acc tgc cct gtg ggc      816
 Lys Cys His Asp Ala Ala Thr Gly Val His Cys Thr Cys Pro Val Gly
             260                 265                 270

 ttc atg ctg cag cca gac agg aag acg tgc aaa gat ata gat gag tgc      864
 Phe Met Leu Gln Pro Asp Arg Lys Thr Cys Lys Asp Ile Asp Glu Cys
         275                 280                 285

 cgc tta aac aac ggg ggc tgt gac cat att tgc cgc aac aca gtg ggc      912
 Arg Leu Asn Asn Gly Gly Cys Asp His Ile Cys Arg Asn Thr Val Gly
     290                 295                 300

 agc ttc gaa tgc agt tgc aag aaa ggc tat aag ctt ctc atc aat gag      960
 Ser Phe Glu Cys Ser Cys Lys Lys Gly Tyr Lys Leu Leu Ile Asn Glu
 305                 310                 315                 320

 agg aac tgc cag gat ata gac gag tgt tcc ttt gat cga acc tgt gac     1008
 Arg Asn Cys Gln Asp Ile Asp Glu Cys Ser Phe Asp Arg Thr Cys Asp
                 325                 330                 335

 cac ata tgt gtc aac aca cca gga agc ttc cag tgt ctc tgc cat cgt     1056
 His Ile Cys Val Asn Thr Pro Gly Ser Phe Gln Cys Leu Cys His Arg
             340                 345                 350

 ggc tac ctg ttg tat ggt atc acc cac tgt ggg gat gtg gat gaa tgc     1104
 Gly Tyr Leu Leu Tyr Gly Ile Thr His Cys Gly Asp Val Asp Glu Cys
         355                 360                 365

 agc atc aac cgg gga ggt tgc cgc ttt ggc tgc atc aac act cct ggc     1152
 Ser Ile Asn Arg Gly Gly Cys Arg Phe Gly Cys Ile Asn Thr Pro Gly
     370                 375                 380

 agc tac cag tgt acc tgc cca gca ggc cag ggt cgg ctg cac tgg aat     1200
 Ser Tyr Gln Cys Thr Cys Pro Ala Gly Gln Gly Arg Leu His Trp Asn
 385                 390                 395                 400

 ggc aaa gat tgc aca gag cca ctg aag tgt cag ggc agt cct ggg gcc     1248
 Gly Lys Asp Cys Thr Glu Pro Leu Lys Cys Gln Gly Ser Pro Gly Ala
                 405                 410                 415

 tcg aaa gcc atg ctc agc tgc aac cgg tct ggc aag aag gac acc tgt     1296
 Ser Lys Ala Met Leu Ser Cys Asn Arg Ser Gly Lys Lys Asp Thr Cys
             420                 425                 430

 gcc ctg acc tgt ccc tcc agg gcc cga ttt ttg cca gag tct gag aat     1344
 Ala Leu Thr Cys Pro Ser Arg Ala Arg Phe Leu Pro Glu Ser Glu Asn
         435                 440                 445

 ggc ttc acg gtg agc tgt ggg acc ccc agc ccc agg gct gct cca gcc     1392
 Gly Phe Thr Val Ser Cys Gly Thr Pro Ser Pro Arg Ala Ala Pro Ala
     450                 455                 460

 cga gct ggc cac aat ggg aac agc acc aac tcc aac cac tgc cat gag     1440
 Arg Ala Gly His Asn Gly Asn Ser Thr Asn Ser Asn His Cys His Glu
 465                 470                 475                 480

 gct gca gtg ctg tcc att aaa caa cgg gcc tcc ttc aag atc aag gat     1488
 Ala Ala Val Leu Ser Ile Lys Gln Arg Ala Ser Phe Lys Ile Lys Asp
                 485                 490                 495

 gcc aaa tgc cgt ttg cac ctg cga aac aaa ggc aaa aca gag gag gct     1536
 Ala Lys Cys Arg Leu His Leu Arg Asn Lys Gly Lys Thr Glu Glu Ala
             500                 505                 510

 ggc aga atc aca ggg cca ggt ggt gcc ccc tgc tct gaa tgc cag gtc     1584
 Gly Arg Ile Thr Gly Pro Gly Gly Ala Pro Cys Ser Glu Cys Gln Val
         515                 520                 525

 acc ttc atc cac ctt aag tgt gac tcc tct cgg aag ggc aag ggc cga     1632
 Thr Phe Ile His Leu Lys Cys Asp Ser Ser Arg Lys Gly Lys Gly Arg
     530                 535                 540

 cgg gcc cgg acc cct cca ggc aaa gag gtc aca agg ctc acc ctg gaa     1680
 Arg Ala Arg Thr Pro Pro Gly Lys Glu Val Thr Arg Leu Thr Leu Glu
 545                 550                 555                 560

 ctg gag gca gag caa ctc ttt ctc ctc cct gat aca cac ggc cat cca     1728
 Leu Glu Ala Glu Gln Leu Phe Leu Leu Pro Asp Thr His Gly His Pro
                 565                 570                 575

 cca cca gcc agc tgt ggg ctg ccc tgc ctc cga cag cga atg gaa cgg     1776
 Pro Pro Ala Ser Cys Gly Leu Pro Cys Leu Arg Gln Arg Met Glu Arg
             580                 585                 590

 cgg ctg aaa gga tcc ctg aag atg ctc aga aag tcc atc aac cag gac     1824
 Arg Leu Lys Gly Ser Leu Lys Met Leu Arg Lys Ser Ile Asn Gln Asp
         595                 600                 605

 cgc ttc ctg ctg cgc ctg gca ggc ctt gat tat gag ctg gcc cac aag     1872
 Arg Phe Leu Leu Arg Leu Ala Gly Leu Asp Tyr Glu Leu Ala His Lys
     610                 615                 620

 ccg ggc ctg gta gcc ggg gag cga gca gag ccg atg gag tcc tgt agg     1920
 Pro Gly Leu Val Ala Gly Glu Arg Ala Glu Pro Met Glu Ser Cys Arg
 625                 630                 635                 640

 ccc ggg cag cac cgt gct ggg acc aag tgt gtc cag tgc tcc cca ggg     1968
 Pro Gly Gln His Arg Ala Gly Thr Lys Cys Val Gln Cys Ser Pro Gly
                 645                 650                 655

 cac tac tac aac acc agc atc cac cgc tgt att cgc tgt gcc atg ggc     2016
 His Tyr Tyr Asn Thr Ser Ile His Arg Cys Ile Arg Cys Ala Met Gly
             660                 665                 670

 tcc tat cag ccc gac ttc cgt cag aac ttc tgc agc cgc tgt cca gga     2064
 Ser Tyr Gln Pro Asp Phe Arg Gln Asn Phe Cys Ser Arg Cys Pro Gly
         675                 680                 685

 aac aca agc aca gac ttt gat ggc tct acc agt gtg gcc caa tgc aag     2112
 Asn Thr Ser Thr Asp Phe Asp Gly Ser Thr Ser Val Ala Gln Cys Lys
     690                 695                 700

 aat cgt cag tgt ggt ggg gag ctg ggt gag ttc act ggc tat att gag     2160
 Asn Arg Gln Cys Gly Gly Glu Leu Gly Glu Phe Thr Gly Tyr Ile Glu
 705                 710                 715                 720

 tcc ccc aac tac ccg ggc aac tac cca gct ggt gtg gag tgc atc tgg     2208
 Ser Pro Asn Tyr Pro Gly Asn Tyr Pro Ala Gly Val Glu Cys Ile Trp
                 725                 730                 735

 aac atc aac ccc cca ccc aag cgc aag atc ctt atc gtg gta cca gag     2256
 Asn Ile Asn Pro Pro Pro Lys Arg Lys Ile Leu Ile Val Val Pro Glu
             740                 745                 750

 atc ttc ctg cca tct gag gat gag tgt ggg gac gtc ctc gtc atg aga     2304
 Ile Phe Leu Pro Ser Glu Asp Glu Cys Gly Asp Val Leu Val Met Arg
         755                 760                 765

 aag aac tca tcc cca tcc tcc att acc act tat gag acc tgc cag acc     2352
 Lys Asn Ser Ser Pro Ser Ser Ile Thr Thr Tyr Glu Thr Cys Gln Thr
     770                 775                 780

 tac gag cgt ccc att gcc ttc act gcc cgt tcc agg aag ctc tgg atc     2400
 Tyr Glu Arg Pro Ile Ala Phe Thr Ala Arg Ser Arg Lys Leu Trp Ile
 785                 790                 795                 800

 aac ttc aag aca agc gag gcc aac agc gcc cgt ggc ttc cag att ccc     2448
 Asn Phe Lys Thr Ser Glu Ala Asn Ser Ala Arg Gly Phe Gln Ile Pro
                 805                 810                 815

 tat gtt acc tat gat gag gac tat gag cag ctg gta gaa gac att gtg     2496
 Tyr Val Thr Tyr Asp Glu Asp Tyr Glu Gln Leu Val Glu Asp Ile Val
             820                 825                 830

 cga gat ggc cgg ctc tat gcc tct gaa aac cac cag gag att tta aag     2544
 Arg Asp Gly Arg Leu Tyr Ala Ser Glu Asn His Gln Glu Ile Leu Lys
         835                 840                 845

 gac aag aag ctc atc aag gcc ttc ttt gag gtg cta gcc cac ccc cag     2592
 Asp Lys Lys Leu Ile Lys Ala Phe Phe Glu Val Leu Ala His Pro Gln
     850                 855                 860

 aac tac ttc aag tac aca gag aaa cac aag gag atg ctg cca aaa tcc     2640
 Asn Tyr Phe Lys Tyr Thr Glu Lys His Lys Glu Met Leu Pro Lys Ser
 865                 870                 875                 880

 ttc atc aag ctg ctc cgc tcc aaa gtt tcc agc ttc ctg agg ccc tac     2688
 Phe Ile Lys Leu Leu Arg Ser Lys Val Ser Ser Phe Leu Arg Pro Tyr
                 885                 890                 895

 aaa tag                                                             2694
 Lys 






      <210> 8
      <211> 941
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (279)..(941)

      <400> 8
 ggctttcccg tcgcttctcc caggcagagc agcacataac catagttcca ctgcatctgt     60

 ccgctggctg cagcgactcg gatacagtct tccaagaatc tgtaacctgg gacttttgag    120

 ggggagggga caagcaggta gggtatcaga gaaaggatgg gttagactcc cgaccatgag    180

 tgaaaagggc cgtgtgcgtg ctccaggagt gtcggtcccc ctctgcaatt caaaaggggg    240

 atctctcctg tgcgcgggtt ttttgggacc ggctccag    atg tct ccc agc agt     293
                                              Met Ser Pro Ser Ser
                                                1               5

 ttt ctc cgg cag gtt tgc ctc gga gcg tgt gaa cat tcc tcc gct cgg      341
 Phe Leu Arg Gln Val Cys Leu Gly Ala Cys Glu His Ser Ser Ala Arg
                  10                  15                  20

 ttt tca act cgc ctc caa cct gcg ccg ccc ggc cag cat gtc tcc ccg      389
 Phe Ser Thr Arg Leu Gln Pro Ala Pro Pro Gly Gln His Val Ser Pro
              25                  30                  35

 ccc gcc cga gcg cga gcg gag acg atg cag cgg aga ctg gtt cag cag      437
 Pro Ala Arg Ala Arg Ala Glu Thr Met Gln Arg Arg Leu Val Gln Gln
          40                  45                  50

 tgg agc gtc gcg gtg ttc ctg ctg agc tac gcg gtg ccc tcc tgc ggg      485
 Trp Ser Val Ala Val Phe Leu Leu Ser Tyr Ala Val Pro Ser Cys Gly
      55                  60                  65

 cgc tcg gtg gag ggt ctc agc cgc cgc ctc aaa aga gct gtg tct gaa      533
 Arg Ser Val Glu Gly Leu Ser Arg Arg Leu Lys Arg Ala Val Ser Glu
  70                  75                  80                  85

 cat cag ctc ctc cat gac aag ggg aag tcc atc caa gat tta cgg cga      581
 His Gln Leu Leu His Asp Lys Gly Lys Ser Ile Gln Asp Leu Arg Arg
                  90                  95                 100

 cga ttc ttc ctt cac cat ctg atc gca gaa atc cac aca gct gaa atc      629
 Arg Phe Phe Leu His His Leu Ile Ala Glu Ile His Thr Ala Glu Ile
             105                 110                 115

 aga gct acc tcg gag gtg tcc cct aac tcc aag ccc tct ccc aac aca      677
 Arg Ala Thr Ser Glu Val Ser Pro Asn Ser Lys Pro Ser Pro Asn Thr
         120                 125                 130

 aag aac cac ccc gtc cga ttt ggg tct gat gat gag ggc aga tac cta      725
 Lys Asn His Pro Val Arg Phe Gly Ser Asp Asp Glu Gly Arg Tyr Leu
     135                 140                 145

 act cag gaa act aac aag gtg gag acg tac aaa gag cag ccg ctc aag      773
 Thr Gln Glu Thr Asn Lys Val Glu Thr Tyr Lys Glu Gln Pro Leu Lys
 150                 155                 160                 165

 aca cct ggg aag aaa aag aaa ggc aag ccc ggg aaa cgc aag gag cag      821
 Thr Pro Gly Lys Lys Lys Lys Gly Lys Pro Gly Lys Arg Lys Glu Gln
                 170                 175                 180

 gaa aag aaa aaa cgg cga act cgc tct gcc tgg tta gac tct gga gtg      869
 Glu Lys Lys Lys Arg Arg Thr Arg Ser Ala Trp Leu Asp Ser Gly Val
             185                 190                 195

 act ggg agt ggg cta gaa ggg gac cac ctg tct gac acc tcc aca acg      917
 Thr Gly Ser Gly Leu Glu Gly Asp His Leu Ser Asp Thr Ser Thr Thr
         200                 205                 210

 tcg ctg gag ctc gat tca cgg taa                                      941
 Ser Leu Glu Leu Asp Ser Arg 
     215                 220





      <210> 9
      <211> 1610
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (99)..(1556)

      <400> 9
 atgcacaggt gccaggtggt ccggggcctc gcccgctgtg agtgccacgt gggctatcag     60

 ctagcagcgg acggcaaggc ctgtgaagat gtggacga    atg tgc cgc atg gct     113
                                              Met Cys Arg Met Ala
                                                1               5

 ggc cag tgt gcc cat ggc tgc ctc aac acc cag ggg tcc ttc aag tgc      161
 Gly Gln Cys Ala His Gly Cys Leu Asn Thr Gln Gly Ser Phe Lys Cys
                  10                  15                  20

 gtg tgt cac gcg ggc tat gag ctg ggc gcc gat ggc cgg cag tgc tac      209
 Val Cys His Ala Gly Tyr Glu Leu Gly Ala Asp Gly Arg Gln Cys Tyr
              25                  30                  35

 cgg att gag atg gaa atc gtg aac agc tgt gag gcc aac aac ggc ggc      257
 Arg Ile Glu Met Glu Ile Val Asn Ser Cys Glu Ala Asn Asn Gly Gly
          40                  45                  50

 tgc tcc cat ggc tgc agc cac acc agt gct ggg ccc ctg tgc aca tgt      305
 Cys Ser His Gly Cys Ser His Thr Ser Ala Gly Pro Leu Cys Thr Cys
      55                  60                  65

 ccc cgc ggc tac gag ctg gac aca gat cag agg acc tgc atc gat gtc      353
 Pro Arg Gly Tyr Glu Leu Asp Thr Asp Gln Arg Thr Cys Ile Asp Val
  70                  75                  80                  85

 gac gac tgt gca gac agc ccg tgc tgc cag cag gtg tgc acc aac aac      401
 Asp Asp Cys Ala Asp Ser Pro Cys Cys Gln Gln Val Cys Thr Asn Asn
                  90                  95                 100

 cct ggc ggg tac gag tgc ggc tgc tac gcc ggc tac cgg ctc agt gcc      449
 Pro Gly Gly Tyr Glu Cys Gly Cys Tyr Ala Gly Tyr Arg Leu Ser Ala
             105                 110                 115

 gat ggc tgc ggc tgt gag gat gtg gat gag tgc gcc tcc agc cgt ggc      497
 Asp Gly Cys Gly Cys Glu Asp Val Asp Glu Cys Ala Ser Ser Arg Gly
         120                 125                 130

 ggc tgc gag cac cac tgc acc aac ctg gcc ggc tcc ttc cag tgc tcc      545
 Gly Cys Glu His His Cys Thr Asn Leu Ala Gly Ser Phe Gln Cys Ser
     135                 140                 145

 tgc gag gcc ggc tac cgg ctg cac gag gac cgt agg ggc tgc agc ccc      593
 Cys Glu Ala Gly Tyr Arg Leu His Glu Asp Arg Arg Gly Cys Ser Pro
 150                 155                 160                 165

 ctg gag gag ccg atg gtg gac ctg gac ggc gag ctg cct ttc gtg cgg      641
 Leu Glu Glu Pro Met Val Asp Leu Asp Gly Glu Leu Pro Phe Val Arg
                 170                 175                 180

 ccc ctg ccc cac att gcc gtg ctc cag gac gag ctg ccg caa ctc ttc      689
 Pro Leu Pro His Ile Ala Val Leu Gln Asp Glu Leu Pro Gln Leu Phe
             185                 190                 195

 cag gat gac gac gtc ggg gcc gat gag gaa gag gca gag ttg cgg ggc      737
 Gln Asp Asp Asp Val Gly Ala Asp Glu Glu Glu Ala Glu Leu Arg Gly
         200                 205                 210

 gaa cac acg ctc aca gag aag ttt gtc tgc ctg gat gac tcc ttt ggc      785
 Glu His Thr Leu Thr Glu Lys Phe Val Cys Leu Asp Asp Ser Phe Gly
     215                 220                 225

 cat gac tgc agc ttg acc tgt gat gac tgc agg aac gga ggg acc tgc      833
 His Asp Cys Ser Leu Thr Cys Asp Asp Cys Arg Asn Gly Gly Thr Cys
 230                 235                 240                 245

 ctc ctg ggc ctg gat ggc tgt gat tgc ccc gag ggc tgg act ggg ctc      881
 Leu Leu Gly Leu Asp Gly Cys Asp Cys Pro Glu Gly Trp Thr Gly Leu
                 250                 255                 260

 atc tgc aat gag act tgt cct ccg gac acc ttt ggg aag aac tgc agc      929
 Ile Cys Asn Glu Thr Cys Pro Pro Asp Thr Phe Gly Lys Asn Cys Ser
             265                 270                 275

 ttc tcc tgc agc tgt cag aat ggt ggg acc tgc gac tct gtc acg ggg      977
 Phe Ser Cys Ser Cys Gln Asn Gly Gly Thr Cys Asp Ser Val Thr Gly
         280                 285                 290

 gcc tgc cgc tgc ccc ccg ggt gtc agt gga act aac tgt gag gat ggc     1025
 Ala Cys Arg Cys Pro Pro Gly Val Ser Gly Thr Asn Cys Glu Asp Gly
     295                 300                 305

 tgc ccc aag ggc tac tat ggc aag cac tgt cgc aag aaa tgc aac tgt     1073
 Cys Pro Lys Gly Tyr Tyr Gly Lys His Cys Arg Lys Lys Cys Asn Cys
 310                 315                 320                 325

 gcc aac cgg ggc cgg tgc cac cgc ctc tac ggg gcc tgc ctc tgc gac     1121
 Ala Asn Arg Gly Arg Cys His Arg Leu Tyr Gly Ala Cys Leu Cys Asp
                 330                 335                 340

 cca ggg ctc tac ggc cgc ttc tgc cac ctc acc tgc ccg ccg tgg gcc     1169
 Pro Gly Leu Tyr Gly Arg Phe Cys His Leu Thr Cys Pro Pro Trp Ala
             345                 350                 355

 ttt ggg ccg ggc tgc tcg gag gag tgc cag tgt gtg cag ccc cac acg     1217
 Phe Gly Pro Gly Cys Ser Glu Glu Cys Gln Cys Val Gln Pro His Thr
         360                 365                 370

 ctg tcc tgt gac aag agg gat ggc agc tgc tcc tgc aag gct ggc ttc     1265
 Leu Ser Cys Asp Lys Arg Asp Gly Ser Cys Ser Cys Lys Ala Gly Phe
     375                 380                 385

 cgg ggc gag cgc tgt cag gca gag tgt gag ctg ggc tac ttt ggg ccg     1313
 Arg Gly Glu Arg Cys Gln Ala Glu Cys Glu Leu Gly Tyr Phe Gly Pro
 390                 395                 400                 405

 ggg tgc tgg cag gca tgc acc tgc cca gtg ggc gtg gcc tgt gac tcc     1361
 Gly Cys Trp Gln Ala Cys Thr Cys Pro Val Gly Val Ala Cys Asp Ser
                 410                 415                 420

 gtg agc ggc gag tgt ggg aag cgg tgt cct gct ggc ttc cag gga gag     1409
 Val Ser Gly Glu Cys Gly Lys Arg Cys Pro Ala Gly Phe Gln Gly Glu
             425                 430                 435

 gac tgt ggc caa gcc cag gtg gtg cct tgc tac cgg tgt tgc ctt gct     1457
 Asp Cys Gly Gln Ala Gln Val Val Pro Cys Tyr Arg Cys Cys Leu Ala
         440                 445                 450

 acc ggt gtt gcc ttg acg gcc tgt cac atg gca gtg gtg cgg ctg cta     1505
 Thr Gly Val Ala Leu Thr Ala Cys His Met Ala Val Val Arg Leu Leu
     455                 460                 465

 gtc tca gtc tgg tct act cag ggc agc agc tgc tgt ctg ccc agg gcc     1553
 Val Ser Val Trp Ser Thr Gln Gly Ser Ser Cys Cys Leu Pro Arg Ala
 470                 475                 480                 485

 tga cctg gggaggggcc aggttctctc caaactcctc cctggtccac ttgcttcttg     1610
 






      <210> 10
      <211> 479
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (41)..(238)

      <400> 10
 gcaccaggcc agctctcctc ccacaacagc ttcccacagc  atg aag atc tcc gtg      55
                                              Met Lys Ile Ser Val
                                                1               5

 gct gcc att ccc ttc ttc ctc ctc atc acc atc gcc cta ggg acc aag      103
 Ala Ala Ile Pro Phe Phe Leu Leu Ile Thr Ile Ala Leu Gly Thr Lys
                  10                  15                  20

 act gaa tcc tcc tca cgg gga cct tac cac ccc tca gag tgc tgc ttc      151
 Thr Glu Ser Ser Ser Arg Gly Pro Tyr His Pro Ser Glu Cys Cys Phe
              25                  30                  35

 acc tac act acc tac aag atc ccg cgt cag cgg att atg gat tac tat      199
 Thr Tyr Thr Thr Tyr Lys Ile Pro Arg Gln Arg Ile Met Asp Tyr Tyr
          40                  45                  50

 gag acc aac agc cag tgc tcc aag ccc gga att gtg tag cttcatcacc       248
 Glu Thr Asn Ser Gln Cys Ser Lys Pro Gly Ile Val 
      55                  60                  65

 aaaaggggcc attccgtctg taccaacccc agtgacaagt gggtccagga ctatatcaag    308

 gacatgaagg agaactgagt gacccagaag gggtggcgaa ggcacagctc agagacataa    368

 agagaagatg ccaaggcccc ctcctccacc caccgctaac tctcagcccc agtcaccctc    428

 ttggagcttc cctgctttga attaaagacc actcatgcta aaaaaaaaaa a             479




      <210> 11
      <211> 1443
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (103)..(1443)

      <400> 11
 atgcagggca cccctggagg cgggacgcgc cctgggccat cccccgtgga caggcggaca     60

 ctcctggtct tcagctttat cctggcagca gctttgggcc aa   atg aat ttc aca     114
                                                  Met Asn Phe Thr
                                                    1

 ggg gac cag gtt ctt cga gtc ctg gcc aaa gat gag aag cag ctt tca      162
 Gly Asp Gln Val Leu Arg Val Leu Ala Lys Asp Glu Lys Gln Leu Ser
   5                  10                  15                  20

 ctt ctc ggg gat ctg gag ggc ctg aaa ccc cag aag gtg gac ttc tgg      210
 Leu Leu Gly Asp Leu Glu Gly Leu Lys Pro Gln Lys Val Asp Phe Trp
                  25                  30                  35

 cgt ggc cca gcc agg ccc agc ctc cct gtg gat atg aga gtt cct ttc      258
 Arg Gly Pro Ala Arg Pro Ser Leu Pro Val Asp Met Arg Val Pro Phe
              40                  45                  50

 tct gaa ctg aaa gac atc aaa gct tat ctg gag tct cat gga ctt gct      306
 Ser Glu Leu Lys Asp Ile Lys Ala Tyr Leu Glu Ser His Gly Leu Ala
          55                  60                  65

 tac agc atc atg ata aag gac atc cag ttc aca ctc atg gtg gct cat      354
 Tyr Ser Ile Met Ile Lys Asp Ile Gln Phe Thr Leu Met Val Ala His
      70                  75                  80

 tct cct gtg ttg ctg ctg tct tta tgc aca gcc agt gga ggc agg gct      402
 Ser Pro Val Leu Leu Leu Ser Leu Cys Thr Ala Ser Gly Gly Arg Ala
  85                  90                  95                 100

 cag aag agg cat agc cag ccc agc tct ccc ctt cct ttc caa tat gtg      450
 Gln Lys Arg His Ser Gln Pro Ser Ser Pro Leu Pro Phe Gln Tyr Val
                 105                 110                 115

 ttc ccc atc acc cag gtg ctg ctg gat gag gaa aga cag gcc atg gcg      498
 Phe Pro Ile Thr Gln Val Leu Leu Asp Glu Glu Arg Gln Ala Met Ala
             120                 125                 130

 aaa tcc cgc cgg ctg gag cgc agc acc aac agc ttc agt tac tca tca      546
 Lys Ser Arg Arg Leu Glu Arg Ser Thr Asn Ser Phe Ser Tyr Ser Ser
         135                 140                 145

 tac cac acc ctg gag gag ata tat agc tgg att gac aac ttt gta atg      594
 Tyr His Thr Leu Glu Glu Ile Tyr Ser Trp Ile Asp Asn Phe Val Met
     150                 155                 160

 gag cat tcc gat att gtc tca aaa att cag att ggc aac agc ttt gaa      642
 Glu His Ser Asp Ile Val Ser Lys Ile Gln Ile Gly Asn Ser Phe Glu
 165                 170                 175                 180

 aac cag tcc att ctt gtc ctg aag ttc agc act gga ggt tct cgg cac      690
 Asn Gln Ser Ile Leu Val Leu Lys Phe Ser Thr Gly Gly Ser Arg His
                 185                 190                 195

 cca gcc atc tgg att gac act gga att cac tcc cgg gag tgg atc acc      738
 Pro Ala Ile Trp Ile Asp Thr Gly Ile His Ser Arg Glu Trp Ile Thr
             200                 205                 210

 cat gcc acc ggc atc tgg act gcc aat aag att gtc agt gat tat ggc      786
 His Ala Thr Gly Ile Trp Thr Ala Asn Lys Ile Val Ser Asp Tyr Gly
         215                 220                 225

 aaa gac cgt gtc ctg aca gac ata ctg aat gcc atg gac atc ttc ata      834
 Lys Asp Arg Val Leu Thr Asp Ile Leu Asn Ala Met Asp Ile Phe Ile
     230                 235                 240

 gag ctc gtc aca aac cct gat ggg ttt gct ttt acc cac agc atg aac      882
 Glu Leu Val Thr Asn Pro Asp Gly Phe Ala Phe Thr His Ser Met Asn
 245                 250                 255                 260

 tgc tta tgg cgg aag aac aag tcc atc aga cct gga atc ttc tgc atc      930
 Cys Leu Trp Arg Lys Asn Lys Ser Ile Arg Pro Gly Ile Phe Cys Ile
                 265                 270                 275

 ggc gtg gat ctc aac agg aac tgg aag tcg ggt ttt gga gga aat ggt      978
 Gly Val Asp Leu Asn Arg Asn Trp Lys Ser Gly Phe Gly Gly Asn Gly
             280                 285                 290

 tct aac agc aac ccc tgc tca gaa act tat cac ggg ccc tcc cct cag     1026
 Ser Asn Ser Asn Pro Cys Ser Glu Thr Tyr His Gly Pro Ser Pro Gln
         295                 300                 305

 tcg gag ccg gag gtg gct gcc ata gtg aac ttc atc aca gcc cat ggc     1074
 Ser Glu Pro Glu Val Ala Ala Ile Val Asn Phe Ile Thr Ala His Gly
     310                 315                 320

 aac ttc aag gct ctg atc tcc atc cac agc tac tct cag atg ctt atg     1122
 Asn Phe Lys Ala Leu Ile Ser Ile His Ser Tyr Ser Gln Met Leu Met
 325                 330                 335                 340

 tac cct tac ggc cga ttg ctg gag ccc gtt tca aat cag agg gag ttg     1170
 Tyr Pro Tyr Gly Arg Leu Leu Glu Pro Val Ser Asn Gln Arg Glu Leu
                 345                 350                 355

 tac gat ctt gcc aag gat gcg gtg gag gcc ttg tat aag gtc cat ggg     1218
 Tyr Asp Leu Ala Lys Asp Ala Val Glu Ala Leu Tyr Lys Val His Gly
             360                 365                 370

 atc gag tac att ttt ggc agc atc agc acc acc ctc tat gtg gcc agt     1266
 Ile Glu Tyr Ile Phe Gly Ser Ile Ser Thr Thr Leu Tyr Val Ala Ser
         375                 380                 385

 ggg atc acc gtc gac tgg gcc tat gac agt ggc atc aag tac gcc ttc     1314
 Gly Ile Thr Val Asp Trp Ala Tyr Asp Ser Gly Ile Lys Tyr Ala Phe
     390                 395                 400

 agc ttt gag ctc cgg gac act ggg cag tat ggc ttc ctg ctg ccg gcc     1362
 Ser Phe Glu Leu Arg Asp Thr Gly Gln Tyr Gly Phe Leu Leu Pro Ala
 405                 410                 415                 420

 aca cag atc atc ccc acg gcc cag gag acg tgg atg gcg ctt cgg acc     1410
 Thr Gln Ile Ile Pro Thr Ala Gln Glu Thr Trp Met Ala Leu Arg Thr
                 425                 430                 435

 atc atg gag cac acc ctg aat cac ccc tac tag                         1443
 Ile Met Glu His Thr Leu Asn His Pro Tyr 
             440                 445





      <210> 12
      <211> 1831
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (1)..(828)

      <400> 12
  atg gtg ggg gca aat gca aag aga aca ggg gat ctc tgg agc tgg gaa      48
  Met Val Gly Ala Asn Ala Lys Arg Thr Gly Asp Leu Trp Ser Trp Glu
    1               5                  10                  15

 ggg gct gtg ctg acc ctg tct gcc cat cgc cag gca ctc ctg gcc ctg       96
 Gly Ala Val Leu Thr Leu Ser Ala His Arg Gln Ala Leu Leu Ala Leu
              20                  25                  30

 ccg ctg ctg ctg ctt ctc tcc acg ccc ccg tgt gcc ccc cag gtc tcc      144
 Pro Leu Leu Leu Leu Leu Ser Thr Pro Pro Cys Ala Pro Gln Val Ser
          35                  40                  45

 ggg atc cga gga gat gct ctg gag agg ttt tgc ctt cag caa ccc ctg      192
 Gly Ile Arg Gly Asp Ala Leu Glu Arg Phe Cys Leu Gln Gln Pro Leu
      50                  55                  60

 gac tgt gac gac atc tat gcc cag ggc tac cag tca gac ggc gtg tac      240
 Asp Cys Asp Asp Ile Tyr Ala Gln Gly Tyr Gln Ser Asp Gly Val Tyr
  65                  70                  75                  80

 ctc atc tac ccc tcg ggc ccc agt gtg cct gtg ccc gtc ttc tgt gac      288
 Leu Ile Tyr Pro Ser Gly Pro Ser Val Pro Val Pro Val Phe Cys Asp
                  85                  90                  95

 atg acc acc gag ggc ggg aag tgg acg gtt ttc cag aag aga ttc aat      336
 Met Thr Thr Glu Gly Gly Lys Trp Thr Val Phe Gln Lys Arg Phe Asn
             100                 105                 110

 ggc tca gta agt ttc ttc cgc ggc tgg aat gac tac aag ctg ggc ttc      384
 Gly Ser Val Ser Phe Phe Arg Gly Trp Asn Asp Tyr Lys Leu Gly Phe
         115                 120                 125

 ggc cgt gct gat gga gag tac tgg ctg ggg ctg cag aac atg cac ctc      432
 Gly Arg Ala Asp Gly Glu Tyr Trp Leu Gly Leu Gln Asn Met His Leu
     130                 135                 140

 ctg aca ctg aag cag aag tat gag ctg cga gtg gac ttg gag gac ttt      480
 Leu Thr Leu Lys Gln Lys Tyr Glu Leu Arg Val Asp Leu Glu Asp Phe
 145                 150                 155                 160

 gag aac aac acg gcc tat gcc aag tac gct gac ttc tcc atc tcc ccg      528
 Glu Asn Asn Thr Ala Tyr Ala Lys Tyr Ala Asp Phe Ser Ile Ser Pro
                 165                 170                 175

 aac gcg gtc agc gca gag gag gat ggc tac acc ctc ttt gtg gca ggc      576
 Asn Ala Val Ser Ala Glu Glu Asp Gly Tyr Thr Leu Phe Val Ala Gly
             180                 185                 190

 ttt gag gat ggc ggg gca ggt gac tcc ctg tcc tac cac agt ggc cag      624
 Phe Glu Asp Gly Gly Ala Gly Asp Ser Leu Ser Tyr His Ser Gly Gln
         195                 200                 205

 aag ttc tct acc ttc gac cgg gac cag gac ctc ttt gtg cag aac tgc      672
 Lys Phe Ser Thr Phe Asp Arg Asp Gln Asp Leu Phe Val Gln Asn Cys
     210                 215                 220

 gca gct ctc tcc tca gga gcc ttc tgg ttc cgc agc tgc cac ttt gcc      720
 Ala Ala Leu Ser Ser Gly Ala Phe Trp Phe Arg Ser Cys His Phe Ala
 225                 230                 235                 240

 aac ctc aat ggc ttc tac cta ggg tgg ctc cca cct ctc tta tgc caa      768
 Asn Leu Asn Gly Phe Tyr Leu Gly Trp Leu Pro Pro Leu Leu Cys Gln
                 245                 250                 255

 tgg gca tca act ggg ccc agt gga agg gct tct act act ccc tca aac      816
 Trp Ala Ser Thr Gly Pro Ser Gly Arg Ala Ser Thr Thr Pro Ser Asn
             260                 265                 270

 gca ctg aga tga aaa tccgccgggg cctgaagggc tggccccctc aggcaccttt      871
 Ala Leu Arg 
         275

 cctcccctgg acacccatgg tctccatgag tgctccctct gctgcccctg atgcatgctt    931

 ctgctgattc ccgagcacca actccttaca agggggcctt gtggctctca gccatgccac    991

 atccctgtca cacacccagg gcatccattc ctaagccaga cccggctccc ctacacctga   1051

 agttacactg ccagcagttc cccaggcctc ttccgagagg cacatggttc tagcctggac   1111

 ctggctgggc tccatgagaa tgagttgcct ccaccctgtc ccaacagctg acagccagga   1171

 gccactctcc cagctgcagg cctttgtggt gcatcttgtc ctgcttcctc actgtggacc   1231

 cctgtctggg ccaccctagt gtgctaagct gagcagtgca gtgtgaacag ggcccatggt   1291

 gtattctagg ccacagccca gcactcctct gggctgctct caaaccatgt cccatcttca   1351

 gcatccctcc caccaactta ctcccctgtg gtgagtaccg tggaacccca gcccacctca   1411

 ctatcatact cagcttcccc tgatggccca tcccagcccc tgaagctcta tgccaagaac   1471

 acagctaccg cacaccaccc tgaaacagcc acagccaagg taggcatgca tatgaggtct   1531

 tccccatacc ctctgggtgt tgagaggttt agccacatga gggagcagag gacaatctct   1591

 gcagggctgg gagtgggtag ggactgaagg tctcaataaa ccttcagaac ctgaatgaac   1651

 tggcttcata cacacaaaca tatttgttta tcccccaaat gtaggcacct ggctcctcct   1711

 tgctcccctg ctgatggtgt cctaccccga actccaaaaa ttacacctgg agtcaggtgc   1771

 agaagggaac cttgtatttc acaggcctca ttttgatggc aaaaagacag tgtaataata   1831




      <210> 13
      <211> 1059
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (1)..(1059)

      <400> 13
  atg cga cct tgg ggc agc ccc tac tct tcc ggg cag ccc act tcc gcg      48
  Met Arg Pro Trp Gly Ser Pro Tyr Ser Ser Gly Gln Pro Thr Ser Ala
    1               5                  10                  15

 gcc acc ggt gca ggg cat gcc ccg ggg ccg tgg agc tgc ctt gag gtg       96
 Ala Thr Gly Ala Gly His Ala Pro Gly Pro Trp Ser Cys Leu Glu Val
              20                  25                  30

 cag tgt tgg gga tcc aga gcc atg tcg gac ctg cta cta ctg ggc ctg      144
 Gln Cys Trp Gly Ser Arg Ala Met Ser Asp Leu Leu Leu Leu Gly Leu
          35                  40                  45

 att ggg ggc ctg act ctc tta ctg ctg ctg acg ctg ctg gcc ttt gcc      192
 Ile Gly Gly Leu Thr Leu Leu Leu Leu Leu Thr Leu Leu Ala Phe Ala
      50                  55                  60

 ggg tac tca ggg cta ctg gct ggg gtg gaa gtg agt gct ggg tca ccc      240
 Gly Tyr Ser Gly Leu Leu Ala Gly Val Glu Val Ser Ala Gly Ser Pro
  65                  70                  75                  80

 ccc atc cgc aac gtc act gtg gcc tac aag ttc cac atg ggg ctc tat      288
 Pro Ile Arg Asn Val Thr Val Ala Tyr Lys Phe His Met Gly Leu Tyr
                  85                  90                  95

 ggt gag act ggg cgg ctt ttc act gag agc tgc agc atc tct ccc aag      336
 Gly Glu Thr Gly Arg Leu Phe Thr Glu Ser Cys Ser Ile Ser Pro Lys
             100                 105                 110

 ctc cgc tcc atc gct gtc tac tat gac aac ccc cac atg gtg ccc cct      384
 Leu Arg Ser Ile Ala Val Tyr Tyr Asp Asn Pro His Met Val Pro Pro
         115                 120                 125

 gat aag tgc cga tgt gcc gtg ggc agc atc ctg agt gaa ggt gag gaa      432
 Asp Lys Cys Arg Cys Ala Val Gly Ser Ile Leu Ser Glu Gly Glu Glu
     130                 135                 140

 tcg ccc tcc cct gag ctc atc gac ctc tac cag aaa ttt ggc ttc aag      480
 Ser Pro Ser Pro Glu Leu Ile Asp Leu Tyr Gln Lys Phe Gly Phe Lys
 145                 150                 155                 160

 gtg ttc tcc ttc ccg gca ccc agc cat gtg gtg aca gcc acc ttc ccc      528
 Val Phe Ser Phe Pro Ala Pro Ser His Val Val Thr Ala Thr Phe Pro
                 165                 170                 175

 tac acc acc att ctg tcc atc tgg ctg gct acc cgc cgt gtc cat cct      576
 Tyr Thr Thr Ile Leu Ser Ile Trp Leu Ala Thr Arg Arg Val His Pro
             180                 185                 190

 gcc ttg gac acc tac atc aag gag cgg aag ctg tgt gcc tat cct cgg      624
 Ala Leu Asp Thr Tyr Ile Lys Glu Arg Lys Leu Cys Ala Tyr Pro Arg
         195                 200                 205

 ctg gag atc tac cag gaa gac cag atc cat ttc atg tgc cca ctg gca      672
 Leu Glu Ile Tyr Gln Glu Asp Gln Ile His Phe Met Cys Pro Leu Ala
     210                 215                 220

 cgg cag gga gac ttc tat gtg cct gag atg aag gag aca gag tgg aaa      720
 Arg Gln Gly Asp Phe Tyr Val Pro Glu Met Lys Glu Thr Glu Trp Lys
 225                 230                 235                 240

 tgg cgg ggg ctt gtg gag gcc att gac acc cag gtg gat ggc aca gga      768
 Trp Arg Gly Leu Val Glu Ala Ile Asp Thr Gln Val Asp Gly Thr Gly
                 245                 250                 255

 gct gac aca atg agt gac acg agt tct gta agc ttg gaa gtg agc cct      816
 Ala Asp Thr Met Ser Asp Thr Ser Ser Val Ser Leu Glu Val Ser Pro
             260                 265                 270

 ggc agc cgg gag act tca gct gcc aca ctg tca cct ggg gcg agc agc      864
 Gly Ser Arg Glu Thr Ser Ala Ala Thr Leu Ser Pro Gly Ala Ser Ser
         275                 280                 285

 cgt ggc tgg gat gac ggt gac acc cgc agc gag cac agc tac agc gag      912
 Arg Gly Trp Asp Asp Gly Asp Thr Arg Ser Glu His Ser Tyr Ser Glu
     290                 295                 300

 tca ggt gcc agc ggc tcc tct ttt gag gag ctg gac ttg gag ggc gag      960
 Ser Gly Ala Ser Gly Ser Ser Phe Glu Glu Leu Asp Leu Glu Gly Glu
 305                 310                 315                 320

 ggg ccc tta ggg gag tca cgg ctg gac cct ggg act gag ccc ctg ggg     1008
 Gly Pro Leu Gly Glu Ser Arg Leu Asp Pro Gly Thr Glu Pro Leu Gly
                 325                 330                 335

 act acc aag tgg ctc tgg gag ccc act gcc cct gag aag ggc aag gag     1056
 Thr Thr Lys Trp Leu Trp Glu Pro Thr Ala Pro Glu Lys Gly Lys Glu
             340                 345                 350

 taa                                                                 1059
 






      <210> 14
      <211> 417
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (35)..(337)

      <400> 14
 cgctgggtag gccgccctac ccactgttac caac    atg aag ctg ctc gca gga      52
                                          Met Lys Leu Leu Ala Gly
                                            1               5

 act gag cta ctc ctc acc atc tgg agc ctt gaa gga gct ttg gat agg      100
 Thr Glu Leu Leu Leu Thr Ile Trp Ser Leu Glu Gly Ala Leu Asp Arg
              10                  15                  20

 aaa cag gca aag gaa cca tgt gtg gaa agc ctg ggt tct caa tac ttt      148
 Lys Gln Ala Lys Glu Pro Cys Val Glu Ser Leu Gly Ser Gln Tyr Phe
          25                  30                  35

 cag acc gtg act gac tat ggc aag gac ctg atg gat aag gtc aag agc      196
 Gln Thr Val Thr Asp Tyr Gly Lys Asp Leu Met Asp Lys Val Lys Ser
      40                  45                  50

 cca gag ctt cag gcc gag gcc aag tct tac ttt gaa aag cca aag gag      244
 Pro Glu Leu Gln Ala Glu Ala Lys Ser Tyr Phe Glu Lys Pro Lys Glu
  55                  60                  65                  70

 cag ctg aca ccc ctg atc aag aag gct gga acg gaa ctg gtt aac ttc      292
 Gln Leu Thr Pro Leu Ile Lys Lys Ala Gly Thr Glu Leu Val Asn Phe
                  75                  80                  85

 ttg agc tat tta gtg gaa ctt gga aca cag cct gcc acc cat tga agt      340
 Leu Ser Tyr Leu Val Glu Leu Gly Thr Gln Pro Ala Thr His 
              90                  95                 100

 gtccagacca ttgttttcca accccagctg gcctctagaa cacccactgg gcaggcctag    400

 agctcctgtc cctaccc                                                   417




      <210> 15
      <211> 1491
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (653)..(919)

      <400> 15
 atggataaga ctcgctctgg aaaaaccacc ttcgtgacca gggtatctct cctgccagcc     60

 ctcctagccc tgacacacag ctgggactct caggtccgac cagcggtcct gaacccgctc    120

 ccacggcacg ggaactcctt cgtggcgaag cagcatgtgg cgaagcagca gcccctgcgc    180

 tggctcatct acatagaagt cgccctatcc gtgatgtcac cgacagtgcc tttcccagtc    240

 cccgtctgcc tttctgccgc tcagcctacc aacccgctgc cggagccggc agggggaagt    300

 gacgtctgtc tctccctttt ttccctcccg ccccggcatc tgttctcgcc cgaagaagct    360

 ggtccttagc ctgcgctgcg gagcaacctt tcagtggcca gctggagcct gggcaccgtt    420

 cttcaaataa tggcttttaa ttctcagacg agaacgttta ggattacaaa agaaaccggt    480

 tctcttcaca tccttatcct tgtcatgtag cattccgctt gaaattggaa gccgttcaat    540

 gtcagagaga aaccatattt atgaaatgaa agaggcttct cagatgactg caaaccagcc    600

 ttccttactg gttttatcac tggtaatgtt ataaagacag ttgtccagtt tc    atg     655
                                                              Met
                                                                1

 aat ctt gta ggt ttt tgt ttg ttt att tgt ttg ctt tta atg ttg ttg      703
 Asn Leu Val Gly Phe Cys Leu Phe Ile Cys Leu Leu Leu Met Leu Leu
               5                  10                  15

 ttg ttg ctg ttg ttt tcc aaa ttc agt att gta gaa aaa tat gct gcc      751
 Leu Leu Leu Leu Phe Ser Lys Phe Ser Ile Val Glu Lys Tyr Ala Ala
          20                  25                  30

 cca gaa gag atg att gga cac tct caa gcg tgg tgt tgg agt ttg tca      799
 Pro Glu Glu Met Ile Gly His Ser Gln Ala Trp Cys Trp Ser Leu Ser
      35                  40                  45

 tct ctt gca cag cca tct cca cac ctt agt gct tac ctc aag tta gtt      847
 Ser Leu Ala Gln Pro Ser Pro His Leu Ser Ala Tyr Leu Lys Leu Val
  50                  55                  60                  65

 ttt tat att ctg caa aga cga aac caa aat aat cca aat ttg aca caa      895
 Phe Tyr Ile Leu Gln Arg Arg Asn Gln Asn Asn Pro Asn Leu Thr Gln
                  70                  75                  80

 ata cct ggg cta cat ctt att tga gatgtttaac aaatgtctgg atcatctttt     949
 Ile Pro Gly Leu His Leu Ile 
              85

 cttatatatt acgcaggaaa cactgtgaag taagcaaagt tggaatgccc aagtgaaaga   1009

 ccatttgaat atttacaagt agatttcaga caggaatact acagggtggt cacaggataa   1069

 caaattctag gcagcagatt tacatgactt gaggctgtgg gctgttaaga cgctgaaaaa   1129

 ccagggtgtg gaccaagctg gctaaggctg agtggaccca acgtggtgct ggattggatg   1189

 gaggttttac ctaggccctc attatatgct cattaacata ctaaatcaca cacccgccag   1249

 tgccatgaca gttctgagac cagtgtttga tgtaaaaatg gcaccacagt tccaagaaat   1309

 ctccaccttt acccaggaat tttcgtgata ttccaattct tggttaaaga aacccatcaa   1369

 gatgaaaccc cagaacccat tattctctct tgggtatgcc caagctcccc tttcttgagt   1429

 gtgtactttt tgctttgcaa taaatctctt ctttcactaa aaaaaaaaaa aaaaaaagat   1489

 ct                                                                  1491




      <210> 16
      <211> 596
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (88)..(480)

      <400> 16
 ctggggggag ccggggtgca agagggcagg ctggatcagg ccgggcagaa gcggaccggg     60

 ctccgagtgt caacgagagc tagagac    atg agg ctg agc tgg ttc cgg gtc     111
                                  Met Arg Leu Ser Trp Phe Arg Val
                                    1               5

 ctg aca gta ctg tcc atc tgc ctg agc gcc gtg gcc acg gcc acg ggg      159
 Leu Thr Val Leu Ser Ile Cys Leu Ser Ala Val Ala Thr Ala Thr Gly
      10                  15                  20

 gcc gag ggc aaa agg aag ctg cag atc ggg gtc aag aag cgg gtg gac      207
 Ala Glu Gly Lys Arg Lys Leu Gln Ile Gly Val Lys Lys Arg Val Asp
  25                  30                  35                  40

 cac tgt ccc atc aaa tcg cgc aaa ggg gat gtc ctg cac atg cac tac      255
 His Cys Pro Ile Lys Ser Arg Lys Gly Asp Val Leu His Met His Tyr
                  45                  50                  55

 acg ggg aag ctg gaa gat ggg aca gag ttt gac agc agc ctg ccc cag      303
 Thr Gly Lys Leu Glu Asp Gly Thr Glu Phe Asp Ser Ser Leu Pro Gln
              60                  65                  70

 aac cag ccc ttt gtc ttc tcc ctt ggc aca ggc cag gtc atc aag ggc      351
 Asn Gln Pro Phe Val Phe Ser Leu Gly Thr Gly Gln Val Ile Lys Gly
          75                  80                  85

 tgg gac cag ggg ctg ctg ggg atg tgt gag ggg gaa aag cgc aag ctg      399
 Trp Asp Gln Gly Leu Leu Gly Met Cys Glu Gly Glu Lys Arg Lys Leu
      90                  95                 100

 gtg atc cca tcc gag cta ggc ggt gca acc ctg gtg ttc gag gtg gag      447
 Val Ile Pro Ser Glu Leu Gly Gly Ala Thr Leu Val Phe Glu Val Glu
 105                 110                 115                 120

 ctg ctc aaa ata gag cga cga act gag ctg taa ccagactg gggaggggca      498
 Leu Leu Lys Ile Glu Arg Arg Thr Glu Leu 
                 125                 130

 gggggagagg cccccatcag ggaccagact gttccaaaaa aaaaacaaaa aacaaaaaca    558

 aacaaaaaaa cacttaaaag cccaaaaaaa aaaaaaaa                            596




      <210> 17
      <211> 1434
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (1205)..(1411)

      <220>
      <221> misc_feature
      <222> (1)...(1434)
      <223> n = a,t,c or g

      <400> 17
 gaaggcagct atgacctggg caagaaaccc atctacaaga aagcccccac caatgagttc     60

 tacgcgtnaa gcttgcttgt gggcactggc ttggacttta gcggggaggg aanccagggg    120

 attttaaagg gtggacatta gggtagggtg aggtcaacct aatactgact tgtnagtatc    180

 tccagctctg attacctttn aagtgttcag aaaaatggat tcaacttggc ctttctgaag    240

 gcaagactgg gattggatca ctttcttaaa cttccagtta agaatctagg tccgccctca    300

 agcccatact gaccatgcct catccagagc tcctctgaag ccagggggct aacggatgtt    360

 gtgtggagtc ctggctggag gtcctccccc agtggccttc ctcccttcct ttcacagccg    420

 gtctctctgc caggaaatgg gggaaggaac tagaaccacc tgcaccttga gatgtttctg    480

 taaatgggta cttgtgatca cactacggga atctctgtgg tatatacctg gggccattct    540

 aggctctttc aagtgacttt tggaaatcaa ccttttttat ttggggggga ggatggggaa    600

 aagagctgag agtttatgct gaaatggatt tatagaatat ttgtaaatct attttatagt    660

 gtttgtccgt tttcttaact gttcattcct ttgtgcagag tgtatatctc tgcctgggca    720

 agagtgtgga ggtgccgagg tgtcttcatt ctctcgcaca tttccacagc acctgctaag    780

 tttgtattta atggtttttg tttttgtttt tgtttgtttc tttgttctct ttcattaaac    840

 cccttcccca gttttttttt tatactttaa accccgctcc tcatggcctt ggccctttct    900

 gaagctgctt cctcttataa aatagctttt gccgaaacat agtttttttt tagcagatcc    960

 caaaatataa tgaaggggat ggtgggatat ttgtgtctgt gttcttataa tatattatta   1020

 ttcttccttg gttctagaaa aatagataaa tatatttttt tcaggaaaat agggtggtgt   1080

 ttccagttgg atgtggctgg gtggttgagt gcagtgcaat tttcatgtgg ctgggtgggt   1140

 ttttgccttt ttctcttggc cctgttcctg gtgccttctg atggggctgg aatagttgag   1200

 gtgg atg gtt cta ccc ttt ctg cct tct gtt tgg gac cca gct ggt gtt    1249
      Met Val Leu Pro Phe Leu Pro Ser Val Trp Asp Pro Ala Gly Val
        1               5                  10                  15

 ctt tgg ttt ctt tct tca ggc tct agg gct gtg cta tcc aat aca gta     1297
 Leu Trp Phe Leu Ser Ser Gly Ser Arg Ala Val Leu Ser Asn Thr Val
                  20                  25                  30

 acc aca tgc ggc tgt tta aag tta agc caa tta aaa tca cat aag att     1345
 Thr Thr Cys Gly Cys Leu Lys Leu Ser Gln Leu Lys Ser His Lys Ile
              35                  40                  45

 aaa aat tcc ttc ctc agt tgc agt aac cag gtt tct aga ggc gtc act     1393
 Lys Asn Ser Phe Leu Ser Cys Ser Asn Gln Val Ser Arg Gly Val Thr
          50                  55                  60

 gtg tgt ggt cat ggc tag tgtataacga tcgagacata ggg                   1434
 Val Cys Gly His Gly 
      65





      <210> 18
      <211> 449
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (1)..(318)

      <400> 18
  atg caa tgt ctt tat ttc atc ctc att ctt aaa gga tat ttt cat cag      48
  Met Gln Cys Leu Tyr Phe Ile Leu Ile Leu Lys Gly Tyr Phe His Gln
    1               5                  10                  15

 caa cac cac acc ctc ctg atc acc ata gct tta tgt ttc tta cag caa       96
 Gln His His Thr Leu Leu Ile Thr Ile Ala Leu Cys Phe Leu Gln Gln
              20                  25                  30

 caa caa gaa aca aat tta tta gct aac cta acc act aat gac gca aga      144
 Gln Gln Glu Thr Asn Leu Leu Ala Asn Leu Thr Thr Asn Asp Ala Arg
          35                  40                  45

 gac aat tct aag gac ttt caa aac agc aaa gta gga gca gct gct acc      192
 Asp Asn Ser Lys Asp Phe Gln Asn Ser Lys Val Gly Ala Ala Ala Thr
      50                  55                  60

 tct agg gat gag gga tgc aat tgt cca att att ggt gaa att gtc att      240
 Ser Arg Asp Glu Gly Cys Asn Cys Pro Ile Ile Gly Glu Ile Val Ile
  65                  70                  75                  80

 tca tgc tat tgg cta ttt gaa att cct cct cta atg tca gag ctc cgg      288
 Ser Cys Tyr Trp Leu Phe Glu Ile Pro Pro Leu Met Ser Glu Leu Arg
                  85                  90                  95

 act cca gcc cca tgc aac ttc aaa ata tga c aaatgtcttg aaggggagat      339
 Thr Pro Ala Pro Cys Asn Phe Lys Ile 
             100                 105

 tggcatgcag atgaggaagg ccctctcgcc aacacatttg tatttcctct gtactgtgag    399

 actgtgggag atttactgcg acatttataa gctttcttcc aaactcctgg               449




      <210> 19
      <211> 3673
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (307)..(2253)

      <400> 19
 ctactgctcc cagaaggcaa aggaagagct ctgcagggac ttcgtagagg ctctgaagac     60

 cgtggtgggc ggctcccacg tgtccactgc cgcggtggtc cgagagcagc acgggcgcga    120

 tgagtcggtg cacaagtgcg aacctcctga tgctgtggtg tggccccaga acgtggagca    180

 ggtcagccgg ctggcagccc tgtgctatcg ccaaggtgtg cccatcatcc cattcggcac    240

 cagcaccggg ctagggtggc gtctgtgctg tgcaggtaca gtggggctcc ctcgcccggc    300

 ccgagg   atg gtc cca gca cac ctt ggc aca cct gtg gct gcc tcc gcc     348
          Met Val Pro Ala His Leu Gly Thr Pro Val Ala Ala Ser Ala
            1               5                  10

 gcc aca cac ggc acc ttg ggt ctg ctc ccg ccc gtg ggc tgc ctg cct      396
 Ala Thr His Gly Thr Leu Gly Leu Leu Pro Pro Val Gly Cys Leu Pro
  15                  20                  25                  30

 ctg ggg gtc tgg tct ggc tgc tgg ggg gac acc cgc ggg gtg tgg tcc      444
 Leu Gly Val Trp Ser Gly Cys Trp Gly Asp Thr Arg Gly Val Trp Ser
                  35                  40                  45

 ggg gac gtg gcc agg tca gag acc cag gtc tgc agt ggt ctt agc acc      492
 Gly Asp Val Ala Arg Ser Glu Thr Gln Val Cys Ser Gly Leu Ser Thr
              50                  55                  60

 tgc ccc aac cag ggc ggc gtc tgc gtt aac ctg acg cat atg gac cga      540
 Cys Pro Asn Gln Gly Gly Val Cys Val Asn Leu Thr His Met Asp Arg
          65                  70                  75

 atc ctg gag ctg aac cag gag gac ttc tct gtg gtg gtg gag cca ggt      588
 Ile Leu Glu Leu Asn Gln Glu Asp Phe Ser Val Val Val Glu Pro Gly
      80                  85                  90

 gtc acc cgc aaa gcc ctc aac gcc cac ctg cgg gac agc ggc ctc tgg      636
 Val Thr Arg Lys Ala Leu Asn Ala His Leu Arg Asp Ser Gly Leu Trp
  95                 100                 105                 110

 att ccc gtg gac cca ggc gcg gac gcc tct ctc tgt ggc atg gcg gcc      684
 Ile Pro Val Asp Pro Gly Ala Asp Ala Ser Leu Cys Gly Met Ala Ala
                 115                 120                 125

 acc ggg gcg tcg ggg acc aac gcg gtc cgc tac ggc acc atg cgg gac      732
 Thr Gly Ala Ser Gly Thr Asn Ala Val Arg Tyr Gly Thr Met Arg Asp
             130                 135                 140

 aac gtg ctc aca ccc tct ggc cag tgc ctg gct atg gcc cga ctg ctc      780
 Asn Val Leu Thr Pro Ser Gly Gln Cys Leu Ala Met Ala Arg Leu Leu
         145                 150                 155

 agg tct gca acc tgg gag ctg ttc ccc tgg agg ggc tac tgc tcc cag      828
 Arg Ser Ala Thr Trp Glu Leu Phe Pro Trp Arg Gly Tyr Cys Ser Gln
     160                 165                 170

 aag gca aag gga gag ctc tgc agg gac ttc gta gag gct ctg aag gcc      876
 Lys Ala Lys Gly Glu Leu Cys Arg Asp Phe Val Glu Ala Leu Lys Ala
 175                 180                 185                 190

 gtg gtg ggc ggc tcc cac gtg tcc act gcc gcg gtg gtc cga gag cag      924
 Val Val Gly Gly Ser His Val Ser Thr Ala Ala Val Val Arg Glu Gln
                 195                 200                 205

 cac ggg cgc gat gag tcg gtg cac agg tgc gaa cct cct gat gct gtg      972
 His Gly Arg Asp Glu Ser Val His Arg Cys Glu Pro Pro Asp Ala Val
             210                 215                 220

 gtg tgg ccc cag aac gtg gag cag gtc agc cgg ctg gca gcc ctg tgc     1020
 Val Trp Pro Gln Asn Val Glu Gln Val Ser Arg Leu Ala Ala Leu Cys
         225                 230                 235

 tat cgc caa ggt gtg ccc atc atc cca ttc ggc acc ggc acc ggg ctt     1068
 Tyr Arg Gln Gly Val Pro Ile Ile Pro Phe Gly Thr Gly Thr Gly Leu
     240                 245                 250

 gag ggt ggc gtc tgt gct gtg cag ggc ggc gtc tgc gtt aac ctg acg     1116
 Glu Gly Gly Val Cys Ala Val Gln Gly Gly Val Cys Val Asn Leu Thr
 255                 260                 265                 270

 cat atg gac cga atc ctg gag ctg aac cag gag gac ttc tct gtg gtg     1164
 His Met Asp Arg Ile Leu Glu Leu Asn Gln Glu Asp Phe Ser Val Val
                 275                 280                 285

 gtg gag cca ggt gtc acc cgc aaa gcc ctc aac gcc cac ctg cgg gac     1212
 Val Glu Pro Gly Val Thr Arg Lys Ala Leu Asn Ala His Leu Arg Asp
             290                 295                 300

 agc ggc ctc tgg ttt ccc gtg gac cca ggc gcg gac gcc tct ctc tgt     1260
 Ser Gly Leu Trp Phe Pro Val Asp Pro Gly Ala Asp Ala Ser Leu Cys
         305                 310                 315

 ggc atg gcg gcc acc ggg gcg tcg ggg acc aac gcg gtc cgc tac ggc     1308
 Gly Met Ala Ala Thr Gly Ala Ser Gly Thr Asn Ala Val Arg Tyr Gly
     320                 325                 330

 acc atg cgg gac aac gtg ctc aac ctg gag gtg gtg ctg ccc gac ggg     1356
 Thr Met Arg Asp Asn Val Leu Asn Leu Glu Val Val Leu Pro Asp Gly
 335                 340                 345                 350

 cgg ctg ctg cac acg gcg ggc cga ggc cgg cat ttc cgg aag agt gca     1404
 Arg Leu Leu His Thr Ala Gly Arg Gly Arg His Phe Arg Lys Ser Ala
                 355                 360                 365

 gcc ggc tac aac ctc acg ggg ctc ttc gtg ggc tcc gag ggg acg ctg     1452
 Ala Gly Tyr Asn Leu Thr Gly Leu Phe Val Gly Ser Glu Gly Thr Leu
             370                 375                 380

 ggc ctc atc aca gcc acc acc ctg cgc ctg cac cct gcc cct gag gcc     1500
 Gly Leu Ile Thr Ala Thr Thr Leu Arg Leu His Pro Ala Pro Glu Ala
         385                 390                 395

 aca gtg gcc gcc acg tgt gcg ttc ccc agt gtc cag gct gct gtg gac     1548
 Thr Val Ala Ala Thr Cys Ala Phe Pro Ser Val Gln Ala Ala Val Asp
     400                 405                 410

 agc act gta cac atc ctc cag gct gca gtg ccc gta gcc cgc att gag     1596
 Ser Thr Val His Ile Leu Gln Ala Ala Val Pro Val Ala Arg Ile Glu
 415                 420                 425                 430

 ttc ctg gat gaa gtc atg atg gat gcc tgc aac agg tac agc aag ctg     1644
 Phe Leu Asp Glu Val Met Met Asp Ala Cys Asn Arg Tyr Ser Lys Leu
                 435                 440                 445

 aat tgc tta gtg gcg ccc aca ctc ttc ctg gag ttc cat ggc tcc cag     1692
 Asn Cys Leu Val Ala Pro Thr Leu Phe Leu Glu Phe His Gly Ser Gln
             450                 455                 460

 cag gca ctg gag gag cag ctg cag cgc aca gag gag ata gtc cag cag     1740
 Gln Ala Leu Glu Glu Gln Leu Gln Arg Thr Glu Glu Ile Val Gln Gln
         465                 470                 475

 aac gga gcc tct gac ttc tcc tgg gcc aag gag gcc gag gag cgc agc     1788
 Asn Gly Ala Ser Asp Phe Ser Trp Ala Lys Glu Ala Glu Glu Arg Ser
     480                 485                 490

 cgg ctt tgg aca gca cgg cac aat gcc tgg tac gca gcc ctg gcc acg     1836
 Arg Leu Trp Thr Ala Arg His Asn Ala Trp Tyr Ala Ala Leu Ala Thr
 495                 500                 505                 510

 cgg cca ggc tgc aag gca ggg gta act cat agg ctt ccc tct gac cag     1884
 Arg Pro Gly Cys Lys Ala Gly Val Thr His Arg Leu Pro Ser Asp Gln
                 515                 520                 525

 ggc tac tcc acg gat gtg tgt gtg ccc atc tcc cgg ctg ccg gag atc     1932
 Gly Tyr Ser Thr Asp Val Cys Val Pro Ile Ser Arg Leu Pro Glu Ile
             530                 535                 540

 gtg gtg cag acc aag gag gat ctg aat gcc tca gga ctc aca gga agc     1980
 Val Val Gln Thr Lys Glu Asp Leu Asn Ala Ser Gly Leu Thr Gly Ser
         545                 550                 555

 att gtc ggg cat gtg ggt gac ggc aac ttc cac tgc atc ctg ctg gtc     2028
 Ile Val Gly His Val Gly Asp Gly Asn Phe His Cys Ile Leu Leu Val
     560                 565                 570

 aac cct gat gac gcc gag gaa ctg ggc agg gtc aag gct ttt gca gaa     2076
 Asn Pro Asp Asp Ala Glu Glu Leu Gly Arg Val Lys Ala Phe Ala Glu
 575                 580                 585                 590

 cag ctg ggc agg cgg gca ctg gct ctc cac gga acg tgc acg ggg gag     2124
 Gln Leu Gly Arg Arg Ala Leu Ala Leu His Gly Thr Cys Thr Gly Glu
                 595                 600                 605

 cat ggc atc gga atg ggc aag cgg cag ctg ctg cag gag gag gtg ggc     2172
 His Gly Ile Gly Met Gly Lys Arg Gln Leu Leu Gln Glu Glu Val Gly
             610                 615                 620

 gcc gtg ggc gtg gag acc atg cgg cag ctc aag gcc gtg cta gac ccc     2220
 Ala Val Gly Val Glu Thr Met Arg Gln Leu Lys Ala Val Leu Asp Pro
         625                 630                 635

 caa ggc ctc atg aat cca ggc aaa gtg ctg tga agggggtc tgagcactta     2271
 Gln Gly Leu Met Asn Pro Gly Lys Val Leu 
     640                 645

 gcccacaagt tccctgacta cggagccggt tctggaactt ttcttcatgc cacggcccct   2331

 gcaaggaaat agatgctgag gcagtcttcc tgccagcgag cccactgtat ctgggcccaa   2391

 ggccagaggg cccagagaga agcctgagca ccgtgttacc tccctggccc tctggctggc   2451

 cccaggagcc tttggttcag taaacgaccc agggtggttc ccagcaaagc tgcttcctct   2511

 ctgctcctac gcatcctgtc ctggcgagaa gagagcgtct gggtccattc aagactctga   2571

 tgacacccct ccccgaggcc tcccactgcc ggggtcccag gacccttccc ccttcacctg   2631

 gtgacaggaa cactcctttc ctggtatgga acgtgagctc ccgtgacatg atgataggtc   2691

 ttctccttgg ggcctccccc aataaatctg taataaacct gaaacccacc tacagctacc   2751

 tggaagtcag caggcagcac ttcctcccct ccccctccag ggtctctgtc ctttggtcag   2811

 tgaccccttt gttttggggc tgtcctctga cttcttatag cctggggagg aggttggtgc   2871

 tcagggttcg gaaaggaacc caggtccctg tcccagctac tccgcctcag agctgaggac   2931

 ctgcccacgg cacatgtcac tcaggatggg ctccccagct gggcctgaac cgggcctctg   2991

 aacacactga atgtgttcct cagcagctgc cacgtctcta gaaacagaga tgagactatt   3051

 tttgcaccca cctcttcatg gggtgatgta tcgtaccacc agctgttttg ccctcaaggt   3111

 ctgtccaccc gagggcctgc ccctgtcttg ggccggagcc cgtcttgaga ccttggcagt   3171

 tgttcccccc taagcccaca ggagggcgcc cgaaatcatg aagctcagat accacgcggc   3231

 atctgcagct cacgactcct ctgcccaggg cctgcggcac tcagccctgg gcaaacctcc   3291

 tcctagggtc aggtaagtcc tggcagcctg gaagccaagc tagtcctcca tcccctgcag   3351

 gtcccaggaa cctgcagtgc tgtctcatct tccttgcccc tctagccttc ggtccctttt   3411

 ggaaagaggc atgttcacac cccacgccct ccctggtctc cggcccctct cctcctccca   3471

 tcagctgtca gtgctcaggc aggctggtag cgcctttagg ccagaggcag ttggcgcttg   3531

 gagaagcccc aagttcaact tccagtgctt ggaaacccct cattccgtgc tactactggg   3591

 ctccagccga cagagttaac accaacctgc gctggcaggc taatcactcg cggacgtttc   3651

 tgtcccgtgt ggcctggtgg gg                                            3673




      <210> 20
      <211> 297
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (1)..(243)

      <400> 20
  atg gag aag ccc ctc ttc cca tta gtg cct ttg cat tgg ttt ggc ttt      48
  Met Glu Lys Pro Leu Phe Pro Leu Val Pro Leu His Trp Phe Gly Phe
    1               5                  10                  15

 ggc tac aca gca ctg gtt gtt tct ggt ggg atc gtt ggc tat gta aaa       96
 Gly Tyr Thr Ala Leu Val Val Ser Gly Gly Ile Val Gly Tyr Val Lys
              20                  25                  30

 aca gcc gct aca tct gtt act ttt gtt ggt gtt atg gga atg aga tcc      144
 Thr Ala Ala Thr Ser Val Thr Phe Val Gly Val Met Gly Met Arg Ser
          35                  40                  45

 tac tac tat gga aaa ttc atg cct gta ggt tta att gca ggt gcc agt      192
 Tyr Tyr Tyr Gly Lys Phe Met Pro Val Gly Leu Ile Ala Gly Ala Ser
      50                  55                  60

 ttg ctg atg gcc gcc aaa gtt gga gtt cgt atg ttg atg aca tct gat      240
 Leu Leu Met Ala Ala Lys Val Gly Val Arg Met Leu Met Thr Ser Asp
  65                  70                  75                  80

 tag caga agtcatgttc cagcttggac tcatgaagga ttaaaaatct gcatcttcca      297
 






      <210> 21
      <211> 1721
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (579)..(1634)

      <400> 21
 taggggaata gcaagcgtcc cacccgcata cgttcagggc taataaggca ccccagcagc     60

 agtgaagcgc atcgtgctac gccaggggac agttgggatg tggttgagtc agaacaaaaa    120

 acatctcaat gctatctcta ccagctccac cggggatcca tgtaccagtt aactaacagg    180

 gttcgctgga cagggcccag acgggctctg caggtgtatg actggcctgg cttcgagtga    240

 ttcggttact ggttggttcg gaagggaaaa tatagagggg atgtggccac caccgggacc    300

 tggtggggca ctcagtccat tcccattctg gttctcagag gctggagagg cagcagaggg    360

 tccagtggta ggctgggaag ctgaagggtt gctgtcgttc tgcaccgccc ttgttgggtg    420

 cctgctgggt gctgtactct gggtttggct cactgaagtt aggaacctca gaataaacca    480

 tacagaattc tccaatcttc tgcagatcac ccccacggcc agtatatagt gtcagacaac    540

 ctttgaaaac tgaagcgtac cctttggtga gccggata    atg tcc cca ggc tgg     593
                                              Met Ser Pro Gly Trp
                                                1               5

 atc aga ttg cca aca tcg tcc cag aca gag ata ttg atg ctg cct gtt      641
 Ile Arg Leu Pro Thr Ser Ser Gln Thr Glu Ile Leu Met Leu Pro Val
                  10                  15                  20

 ttg tcc gcc act ttg cag gtc cga acc tca tgc ccg tcc ttt gtc ttg      689
 Leu Ser Ala Thr Leu Gln Val Arg Thr Ser Cys Pro Ser Phe Val Leu
              25                  30                  35

 gtc act cgg cct gtc tcc agc aca atg aag ata agg ttc aga ttc ttg      737
 Val Thr Arg Pro Val Ser Ser Thr Met Lys Ile Arg Phe Arg Phe Leu
          40                  45                  50

 agc cca ggc ttg ata tcc ttc aca aag gtc tcc gtc gtc atg ctg cct      785
 Ser Pro Gly Leu Ile Ser Phe Thr Lys Val Ser Val Val Met Leu Pro
      55                  60                  65

 gag cct cgg cac ccc act gga tgg gga ata gag gat gaa ggc tca atg      833
 Glu Pro Arg His Pro Thr Gly Trp Gly Ile Glu Asp Glu Gly Ser Met
  70                  75                  80                  85

 ctt gga tcc ttt gcc ccc atg ctc cac ttc cca agg cct acc tac ccc      881
 Leu Gly Ser Phe Ala Pro Met Leu His Phe Pro Arg Pro Thr Tyr Pro
                  90                  95                 100

 att agg ctg ggg tca ggc agc ctc aac ccc tct aac cct tct aaa aga      929
 Ile Arg Leu Gly Ser Gly Ser Leu Asn Pro Ser Asn Pro Ser Lys Arg
             105                 110                 115

 tta aaa aag aac atc ccc gga ggc ctc caa ctt cag gat cag aat ttg      977
 Leu Lys Lys Asn Ile Pro Gly Gly Leu Gln Leu Gln Asp Gln Asn Leu
         120                 125                 130

 ggg gtc tct gga cag gct gct ttg ggg ctg gaa ggc ccc ctg ccg gga     1025
 Gly Val Ser Gly Gln Ala Ala Leu Gly Leu Glu Gly Pro Leu Pro Gly
     135                 140                 145

 tgc tct ttt agt ctc aag ccg cga agt ggc gga gcc gac gta gac agg     1073
 Cys Ser Phe Ser Leu Lys Pro Arg Ser Gly Gly Ala Asp Val Asp Arg
 150                 155                 160                 165

 ggt agg gaa ccc ggt gca cag cca ggg agt aga atc tta ctg gcc aga     1121
 Gly Arg Glu Pro Gly Ala Gln Pro Gly Ser Arg Ile Leu Leu Ala Arg
                 170                 175                 180

 tct tcc gga acc ctc atc ccg aca agc cgg gac tcg gtc cat ccc ctc     1169
 Ser Ser Gly Thr Leu Ile Pro Thr Ser Arg Asp Ser Val His Pro Leu
             185                 190                 195

 ccc tac ccg cag ccc acc acc cac cca agc cag ccg gca gga ctg tgc     1217
 Pro Tyr Pro Gln Pro Thr Thr His Pro Ser Gln Pro Ala Gly Leu Cys
         200                 205                 210

 acg ccg ctg agc agc ccg cag ggg gag cca cag gct ccg ctg ccg ccg     1265
 Thr Pro Leu Ser Ser Pro Gln Gly Glu Pro Gln Ala Pro Leu Pro Pro
     215                 220                 225

 gat gct gcc ccg tgg aac gcg gga gtg cgg aca ttc ccg gaa gtt tcc     1313
 Asp Ala Ala Pro Trp Asn Ala Gly Val Arg Thr Phe Pro Glu Val Ser
 230                 235                 240                 245

 ccc ggc tgg cct cct ccg gcc aat cag cac cgc ccg ggc gcg ccc tgc     1361
 Pro Gly Trp Pro Pro Pro Ala Asn Gln His Arg Pro Gly Ala Pro Cys
                 250                 255                 260

 gtc ccg ccg cct gcc tcc cca ccc cgc ggc cgc ctt gtt aac tgc aat     1409
 Val Pro Pro Pro Ala Ser Pro Pro Arg Gly Arg Leu Val Asn Cys Asn
             265                 270                 275

 atc cat tcc cat gac agg agt caa ggg gtt acg aag ctc tgg gat gct     1457
 Ile His Ser His Asp Arg Ser Gln Gly Val Thr Lys Leu Trp Asp Ala
         280                 285                 290

 gac cag ggc tct gga aaa ggg aga ggg gcc gga ccc gca gca ggt cac     1505
 Asp Gln Gly Ser Gly Lys Gly Arg Gly Ala Gly Pro Ala Ala Gly His
     295                 300                 305

 gct gca ggc ctg cct ctc cgc aat gat ctc gca aca atc tgc gtc agc     1553
 Ala Ala Gly Leu Pro Leu Arg Asn Asp Leu Ala Thr Ile Cys Val Ser
 310                 315                 320                 325

 tct aag aca caa gtc acc tgc acc cct cca aag cga agc gtg gcc ggc     1601
 Ser Lys Thr Gln Val Thr Cys Thr Pro Pro Lys Arg Ser Val Ala Gly
                 330                 335                 340

 cag gcc cac acg ttt ttg ccg gga aga aca tag agttctcc ctcccaaatg     1652
 Gln Ala His Thr Phe Leu Pro Gly Arg Thr 
             345                 350

 gctacatagt cctggctggg accatatcga ctctagacta gacttcctgt ctagagtgga   1712

 ggcctggcc                                                           1721




      <210> 22
      <211> 1544
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (1)..(1497)

      <400> 22
  atg cgg ccg ccc gcc tgc tgg tgg ctg ctc gcg ccg ccg gcg ctg ctc      48
  Met Arg Pro Pro Ala Cys Trp Trp Leu Leu Ala Pro Pro Ala Leu Leu
    1               5                  10                  15

 gcg ctc ctc acc tgc tcc ctg gct ttt ggt ttg gct tct gaa gat aca       96
 Ala Leu Leu Thr Cys Ser Leu Ala Phe Gly Leu Ala Ser Glu Asp Thr
              20                  25                  30

 aag aaa gag gtc aag cag tct cag gat ttg gag aaa agt ggt ata tca      144
 Lys Lys Glu Val Lys Gln Ser Gln Asp Leu Glu Lys Ser Gly Ile Ser
          35                  40                  45

 agg aaa aat gac ata gac tta aaa gga att gta ttc gtc atc cag agt      192
 Arg Lys Asn Asp Ile Asp Leu Lys Gly Ile Val Phe Val Ile Gln Ser
      50                  55                  60

 caa agt aat tct ttt cat gca aag aga gca gag cag tta aaa aaa agc      240
 Gln Ser Asn Ser Phe His Ala Lys Arg Ala Glu Gln Leu Lys Lys Ser
  65                  70                  75                  80

 atc tta aag cag gct gca gat ctt aca cag gag ctc ccc agt gtc ctc      288
 Ile Leu Lys Gln Ala Ala Asp Leu Thr Gln Glu Leu Pro Ser Val Leu
                  85                  90                  95

 ctc ctt cat cag ctg gct aaa caa gaa ggt gca tgg acc ata ctt ccg      336
 Leu Leu His Gln Leu Ala Lys Gln Glu Gly Ala Trp Thr Ile Leu Pro
             100                 105                 110

 ttg tta ccg cac ttt tct gta aca tat agc aga aat tca tct tgg att      384
 Leu Leu Pro His Phe Ser Val Thr Tyr Ser Arg Asn Ser Ser Trp Ile
         115                 120                 125

 ttc ttc tgt gaa gaa gag aca aga ata cag att cca aaa ctc ttg gaa      432
 Phe Phe Cys Glu Glu Glu Thr Arg Ile Gln Ile Pro Lys Leu Leu Glu
     130                 135                 140

 acc ctc aga aga tat gac ccc tct aag gaa tgg ttt ttg gga aaa gca      480
 Thr Leu Arg Arg Tyr Asp Pro Ser Lys Glu Trp Phe Leu Gly Lys Ala
 145                 150                 155                 160

 tta cat gat gaa gaa gct aca ata att cac cat tat gcc ttt tcc gag      528
 Leu His Asp Glu Glu Ala Thr Ile Ile His His Tyr Ala Phe Ser Glu
                 165                 170                 175

 aat cct aca gtt ttt aag tat cca gac ttt gct gca ggc tgg gcc tta      576
 Asn Pro Thr Val Phe Lys Tyr Pro Asp Phe Ala Ala Gly Trp Ala Leu
             180                 185                 190

 agt att cca ctt gta aac aag ctt acc aag aga cta aag agt gaa tcc      624
 Ser Ile Pro Leu Val Asn Lys Leu Thr Lys Arg Leu Lys Ser Glu Ser
         195                 200                 205

 ttg aaa tcc gac ttt aca ata gat tta aaa cat gag att gcc ctc tac      672
 Leu Lys Ser Asp Phe Thr Ile Asp Leu Lys His Glu Ile Ala Leu Tyr
     210                 215                 220

 atc tgg gac aaa ggc gga gga cct ccc ctg acc cca gtg cct gag ttt      720
 Ile Trp Asp Lys Gly Gly Gly Pro Pro Leu Thr Pro Val Pro Glu Phe
 225                 230                 235                 240

 tgt acc aat gac gtg gac ttc tac tgt gct acc aca ttc cat tct ttt      768
 Cys Thr Asn Asp Val Asp Phe Tyr Cys Ala Thr Thr Phe His Ser Phe
                 245                 250                 255

 cta ccg ctt tgt aga aag cca gtg aag aag aag gat att ttt gtt gca      816
 Leu Pro Leu Cys Arg Lys Pro Val Lys Lys Lys Asp Ile Phe Val Ala
             260                 265                 270

 gta aaa aca tgc aag aaa ttt cat ggt gac aga ata cct att gtt aag      864
 Val Lys Thr Cys Lys Lys Phe His Gly Asp Arg Ile Pro Ile Val Lys
         275                 280                 285

 cag act tgg gag agc cag gca agt ctc att gaa tac tat agt gac tat      912
 Gln Thr Trp Glu Ser Gln Ala Ser Leu Ile Glu Tyr Tyr Ser Asp Tyr
     290                 295                 300

 act gaa aat tcc att cct act gtg gat ttg gga att cct aat aca gat      960
 Thr Glu Asn Ser Ile Pro Thr Val Asp Leu Gly Ile Pro Asn Thr Asp
 305                 310                 315                 320

 aga ggt cat tgt gga aag aca ttt gcc att ttg gaa aga ttt ctg aat     1008
 Arg Gly His Cys Gly Lys Thr Phe Ala Ile Leu Glu Arg Phe Leu Asn
                 325                 330                 335

 cgt agc cag gac aaa aca gca tgg tta gtc att gtg gat gat gat aca     1056
 Arg Ser Gln Asp Lys Thr Ala Trp Leu Val Ile Val Asp Asp Asp Thr
             340                 345                 350

 tta ata agt atc tcc agg ctc cag cac ttg ctt agc tgt tat gac tcc     1104
 Leu Ile Ser Ile Ser Arg Leu Gln His Leu Leu Ser Cys Tyr Asp Ser
         355                 360                 365

 ggc gag cct gtg ttt ctg gga gag cgc tac ggc tac ggc ctg ggc act     1152
 Gly Glu Pro Val Phe Leu Gly Glu Arg Tyr Gly Tyr Gly Leu Gly Thr
     370                 375                 380

 ggt ggc tac agc tac atc acg gga gga gga gga atg gtc ttc agc aga     1200
 Gly Gly Tyr Ser Tyr Ile Thr Gly Gly Gly Gly Met Val Phe Ser Arg
 385                 390                 395                 400

 gaa gcc gtc agg aga ctt ctc gcc agt aaa tgt cga tgc tac agc aat     1248
 Glu Ala Val Arg Arg Leu Leu Ala Ser Lys Cys Arg Cys Tyr Ser Asn
                 405                 410                 415

 gat gct ccc gat gat atg gtc ctg gga atg tgc ttt agt ggc ttg gga     1296
 Asp Ala Pro Asp Asp Met Val Leu Gly Met Cys Phe Ser Gly Leu Gly
             420                 425                 430

 atc cct gtg aca cac agc cct ctc ttc cat cag gct cgg ccg gtg gat     1344
 Ile Pro Val Thr His Ser Pro Leu Phe His Gln Ala Arg Pro Val Asp
         435                 440                 445

 tac cct aag gac tac ctt tct cat caa gtt ccc ata tcg ttc cac aaa     1392
 Tyr Pro Lys Asp Tyr Leu Ser His Gln Val Pro Ile Ser Phe His Lys
     450                 455                 460

 cac tgg aac atc gat cca gtg aag gtg tat ttc aca tgg ttg gca ccc     1440
 His Trp Asn Ile Asp Pro Val Lys Val Tyr Phe Thr Trp Leu Ala Pro
 465                 470                 475                 480

 agt gac gaa gac aaa gcc agg cag gag aca cag aaa ggt ttt cga gag     1488
 Ser Asp Glu Asp Lys Ala Arg Gln Glu Thr Gln Lys Gly Phe Arg Glu
                 485                 490                 495

 gag tta taa atcaggg tgacctgtgc gcctagcctg cgcagggaat gaactggaga     1544
 Glu Leu 






      <210> 23
      <211> 3027
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (1050)..(2312)

      <400> 23
 tttttctttt ttcatttttt ttttaatggc tgccacctct atcacaatca ggaaagtcac     60

 tgtagagtgt caggcagctt ccacaggaac tgttggcttc aggagggcac cactgtgtga    120

 gccaggaatc aggagtgggc tgccactagg acttgtagct gtatatgcac tccacgcatg    180

 ctagacgggc attggcaaga catggtgtct tgttcctctt ctctcactat cataaagctg    240

 gtacctggat gtagaatgct gcttcccaga ctgttcgaac cgtccctgag cgcccgccct    300

 cgtctcccgg caccactggc cccgcagcag ccagttgaga agggcggagg ctgattccaa    360

 tgaagtggca gaccgttagg cggcctctcc aaaaagccag ctatgtcgcc gttagccaag    420

 gtttgagggt cttctccttc tcttcgaggg cccaacctcc cctccagatt tagtacacca    480

 gaggcgtcgc agcaacggct gctgcctgcg cgcctcagct aggcgggctc ggatattttt    540

 aaggccacat tggaaatccc gggcatgctc ccgccggcgg agaaggccca gacaaaatgt    600

 gcgccaatca ggatacagac ttggaggacg tttaccctca ggaccaataa gagggagggc    660

 ggaccgggcc aagggtgccg gttcgctctc cggatttaaa cctcagcggt cggcggttaa    720

 ccgcaggctc ggcgcgtggg ccggcagtgc gcctgcgcaa gttacgcgaa agctaacaga    780

 atctgcggtg ctctgctggc gactggcagg acgcggtgca gagagcggac ttccgcgacg    840

 cgggtaagcc gggcgaaggc cggaagcgga gggacgcggg gacctggtgg ctgccggccc    900

 actgcggcgg gagccctcgc tccttttccc accgtcggga cggtgcagag tggcagcttc    960

 cctccgtgga ttccaggtcc tgcctggcga gccgtcccca acgtctgcgt tcctgaggga   1020

 ggcggccggg gcagcgtgag ctacaggcg  atg tgc gcg gcg ggc cgc agc ccc    1073
                                  Met Cys Ala Ala Gly Arg Ser Pro
                                    1               5

 tgg agg tca cgg tgt gcg ctg gcc gct gcc gcg gtc ttt gcc ccg gtg     1121
 Trp Arg Ser Arg Cys Ala Leu Ala Ala Ala Ala Val Phe Ala Pro Val
      10                  15                  20

 gcc ttt ctg agc tcc tgg gcc gcg ccc ctg gga cca ggc gga ggc cgg     1169
 Ala Phe Leu Ser Ser Trp Ala Ala Pro Leu Gly Pro Gly Gly Gly Arg
  25                  30                  35                  40

 gga cgg ccc cag ggc tgg agg gga gtc ccg aag gcc gct agc gac ctg     1217
 Gly Arg Pro Gln Gly Trp Arg Gly Val Pro Lys Ala Ala Ser Asp Leu
                  45                  50                  55

 ggt cca agc cac gcc cac ggc cag gcg ggg cga ctg cga gct ttg ccg     1265
 Gly Pro Ser His Ala His Gly Gln Ala Gly Arg Leu Arg Ala Leu Pro
              60                  65                  70

 ttg aaa ggc gga gcg tgt ctt gtc gct tct agc tgc acc ttt tgt gga     1313
 Leu Lys Gly Gly Ala Cys Leu Val Ala Ser Ser Cys Thr Phe Cys Gly
          75                  80                  85

 ctg cag cat gga acc gtc caa agt ttt ttt ttt tta ctt gaa tgt aaa     1361
 Leu Gln His Gly Thr Val Gln Ser Phe Phe Phe Leu Leu Glu Cys Lys
      90                  95                 100

 tac caa tca aga tac att gaa ata aga agg tcc tac agt gta ggg gaa     1409
 Tyr Gln Ser Arg Tyr Ile Glu Ile Arg Arg Ser Tyr Ser Val Gly Glu
 105                 110                 115                 120

 gca atg gaa gaa ctt cta cct gat gga caa ata tgg gct aat atg gat     1457
 Ala Met Glu Glu Leu Leu Pro Asp Gly Gln Ile Trp Ala Asn Met Asp
                 125                 130                 135

 cca gaa gaa cga atg ttg gca gct gct aca gct ttt acc cac atc tgt     1505
 Pro Glu Glu Arg Met Leu Ala Ala Ala Thr Ala Phe Thr His Ile Cys
             140                 145                 150

 gca ggg cag ggt gaa gga gat gtc agg aga gaa gcc caa tct atc caa     1553
 Ala Gly Gln Gly Glu Gly Asp Val Arg Arg Glu Ala Gln Ser Ile Gln
         155                 160                 165

 tat gat ccc tac agt aaa gct tca gta gcc cca ggg aag cga cct gct     1601
 Tyr Asp Pro Tyr Ser Lys Ala Ser Val Ala Pro Gly Lys Arg Pro Ala
     170                 175                 180

 ctt cct gtg caa cta cag tac cca cat gta gaa agt aat gtc cct tca     1649
 Leu Pro Val Gln Leu Gln Tyr Pro His Val Glu Ser Asn Val Pro Ser
 185                 190                 195                 200

 gaa aca gtc tct gag gcc tcc caa aga ctc cga aag cca gtg atg aag     1697
 Glu Thr Val Ser Glu Ala Ser Gln Arg Leu Arg Lys Pro Val Met Lys
                 205                 210                 215

 aga aag gtg ctg cgc aga aag cca gat ggg gaa gta tta gta aca gat     1745
 Arg Lys Val Leu Arg Arg Lys Pro Asp Gly Glu Val Leu Val Thr Asp
             220                 225                 230

 gag tcg att atc agt gaa tca gaa tct ggt aca gaa aat gat cag gat     1793
 Glu Ser Ile Ile Ser Glu Ser Glu Ser Gly Thr Glu Asn Asp Gln Asp
         235                 240                 245

 ctc tgg gac tta aga caa agg ctg atg aat gta cag ttc cag gaa gac     1841
 Leu Trp Asp Leu Arg Gln Arg Leu Met Asn Val Gln Phe Gln Glu Asp
     250                 255                 260

 aag gaa tct tca ttt gat gtt tca caa aaa ttt aac cta cca cat gaa     1889
 Lys Glu Ser Ser Phe Asp Val Ser Gln Lys Phe Asn Leu Pro His Glu
 265                 270                 275                 280

 tac caa gga att tct caa gat cag ctc att tgc tct cta caa aga gaa     1937
 Tyr Gln Gly Ile Ser Gln Asp Gln Leu Ile Cys Ser Leu Gln Arg Glu
                 285                 290                 295

 gga atg ggc tct cca gct tac gaa caa gac ctg att gtt gcc agc aga     1985
 Gly Met Gly Ser Pro Ala Tyr Glu Gln Asp Leu Ile Val Ala Ser Arg
             300                 305                 310

 ccc aag tcc ttt att ctc cca aag ctg gac cag tta agc cga aac cgg     2033
 Pro Lys Ser Phe Ile Leu Pro Lys Leu Asp Gln Leu Ser Arg Asn Arg
         315                 320                 325

 ggc aag aca gac cgg gta gcc cgg tat ttt gag tac aaa cgg gac tgg     2081
 Gly Lys Thr Asp Arg Val Ala Arg Tyr Phe Glu Tyr Lys Arg Asp Trp
     330                 335                 340

 gac tca ata cgt tta cct ggt gaa gat cat aga aag gaa tta cgc tgg     2129
 Asp Ser Ile Arg Leu Pro Gly Glu Asp His Arg Lys Glu Leu Arg Trp
 345                 350                 355                 360

 ggt gtc cga gag cag atg ctt tgt cga gca gaa ccc caa tcc aaa cct     2177
 Gly Val Arg Glu Gln Met Leu Cys Arg Ala Glu Pro Gln Ser Lys Pro
                 365                 370                 375

 cag cat ata tat gtc cca aac aat tat cta gta cca aca gag aag aaa     2225
 Gln His Ile Tyr Val Pro Asn Asn Tyr Leu Val Pro Thr Glu Lys Lys
             380                 385                 390

 agg tct gca ctc cgt tgg ggt gtt cgt tgt gac ctt gca aat ggt gtc     2273
 Arg Ser Ala Leu Arg Trp Gly Val Arg Cys Asp Leu Ala Asn Gly Val
         395                 400                 405

 ata ccc agg aag ctt ccc ttc cct ctt tct cct tct taa atctttttaa      2322
 Ile Pro Arg Lys Leu Pro Phe Pro Leu Ser Pro Ser 
     410                 415                 420

 acttctttca caggattgtt tgagataacc tagctcttta tatcttccct tttaaataga   2382

 aacaactgtc ttgagaagct cttcgaaaca ttttatggta aggacttcac ctatcattgg   2442

 tctttcctag ctatatatca cattggtatc agatgatact tccaaattgc cactcaaatc   2502

 cagcaattgc aagataaatc atatcagaga aagaacaaca gacctggtct ttctattttg   2562

 tcaaattagt aagggccctt tgtgtcctgt aacttttttt acctatcaat atgagttgct   2622

 gtgcttcagt gtgtgttttt taagttgctg ggcattacac ttaccaatta aagaattttg   2682

 gaaattcaaa aaaaaaaaaa aaaggccggc cgccaagtct tctaccacca cgatggtcac   2742

 ctatggagcc agggatactt gttcgatggg atctcgcctg ggcaaaatgc attcctcctc   2802

 aagtaaccgg agaccttgcc tggagcccac gacaagtgtt ggtccagtca tggttgcgaa   2862

 aaggtaagag cctccctcaa tgcaaaaatc gagtggctgc aacgcaggat gaaaactcgg   2922

 ggtaaatagg atccacacga agaacgtgac acatatcgaa ctgtagacag aagagacaac   2982

 aacgaaccat tgcaactatc aattagactt atagatacca tcacc                   3027




      <210> 24
      <211> 1832
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (44)..(1774)

      <400> 24
 cgataccgcg tcggaatttc cgggtcgacg atcccgtgca aca  atg gcc cag ggt      55
                                                  Met Ala Gln Gly
                                                    1

 gtc ctc tgg atc cta ctc gga ttg cta ctg tgg tca gac cca ggg aca      103
 Val Leu Trp Ile Leu Leu Gly Leu Leu Leu Trp Ser Asp Pro Gly Thr
   5                  10                  15                  20

 gcc tcc ctg ccc ctg ctc atg gac tct gtc atc cag gcc ctg gct gag      151
 Ala Ser Leu Pro Leu Leu Met Asp Ser Val Ile Gln Ala Leu Ala Glu
                  25                  30                  35

 ctg gag cag aaa gtg cca gct gcc aag gcc aga cac aca gct tct gcg      199
 Leu Glu Gln Lys Val Pro Ala Ala Lys Ala Arg His Thr Ala Ser Ala
              40                  45                  50

 tgg ctg atg tca gct cca aac tct ggc ccc cac aat cgc ctc tac cac      247
 Trp Leu Met Ser Ala Pro Asn Ser Gly Pro His Asn Arg Leu Tyr His
          55                  60                  65

 ttc ctg ctg ggg gca tgg agc ctc aat gct aca gag ttg gat ccc tgc      295
 Phe Leu Leu Gly Ala Trp Ser Leu Asn Ala Thr Glu Leu Asp Pro Cys
      70                  75                  80

 cca cta agc cca gag ctg tta ggc ctg acc aag gag gtg gcc caa cat      343
 Pro Leu Ser Pro Glu Leu Leu Gly Leu Thr Lys Glu Val Ala Gln His
  85                  90                  95                 100

 gac gta cga gaa ggg aag gaa tat ggg gtg gtg ctg gca cct gat ggc      391
 Asp Val Arg Glu Gly Lys Glu Tyr Gly Val Val Leu Ala Pro Asp Gly
                 105                 110                 115

 tcg acc gtg gct gtg gag cct ctg ctg gcg ggg ctg gag gca ggg ctg      439
 Ser Thr Val Ala Val Glu Pro Leu Leu Ala Gly Leu Glu Ala Gly Leu
             120                 125                 130

 caa ggg cgc agg gtc ata aat ttg ccc ttg gac agc atg gct gcc cct      487
 Gln Gly Arg Arg Val Ile Asn Leu Pro Leu Asp Ser Met Ala Ala Pro
         135                 140                 145

 tgg gag act gga gat acc ttt cca gat gtt gtg gcc att gct cca gat      535
 Trp Glu Thr Gly Asp Thr Phe Pro Asp Val Val Ala Ile Ala Pro Asp
     150                 155                 160

 gta aga gcc acc tcc tcc cca gga ctc agg gat ggc tct cca gat gtc      583
 Val Arg Ala Thr Ser Ser Pro Gly Leu Arg Asp Gly Ser Pro Asp Val
 165                 170                 175                 180

 acc act gca gat att gga gcc aac act cca gat gct aca aaa ggc tgt      631
 Thr Thr Ala Asp Ile Gly Ala Asn Thr Pro Asp Ala Thr Lys Gly Cys
                 185                 190                 195

 cca gat gtc caa gct tcc ttg cca gat gcc aaa gcc aag tcc cca ccg      679
 Pro Asp Val Gln Ala Ser Leu Pro Asp Ala Lys Ala Lys Ser Pro Pro
             200                 205                 210

 acc atg gtg gac agc ctc ctg gca gtc acc ctg gct gga aac ctg ggc      727
 Thr Met Val Asp Ser Leu Leu Ala Val Thr Leu Ala Gly Asn Leu Gly
         215                 220                 225

 ctg acc ttc ctc cga ggt tcc cag acc cag agc cat cca gac ctg gga      775
 Leu Thr Phe Leu Arg Gly Ser Gln Thr Gln Ser His Pro Asp Leu Gly
     230                 235                 240

 act gag ggc tgc tgg gac cag ctc tct gcc cct cgg acc ttt acg ctt      823
 Thr Glu Gly Cys Trp Asp Gln Leu Ser Ala Pro Arg Thr Phe Thr Leu
 245                 250                 255                 260

 ttg gac ccc aag gca tct ctg tta acc atg gcc ttc ctc aat ggc gcc      871
 Leu Asp Pro Lys Ala Ser Leu Leu Thr Met Ala Phe Leu Asn Gly Ala
                 265                 270                 275

 ctg gat ggg gtc atc ctt gga gac tac ctg agc cgg act cct gag ccc      919
 Leu Asp Gly Val Ile Leu Gly Asp Tyr Leu Ser Arg Thr Pro Glu Pro
             280                 285                 290

 cgg cca tcc ctc agc cac ttg ctg agc cag tac tat ggg gct ggg gtg      967
 Arg Pro Ser Leu Ser His Leu Leu Ser Gln Tyr Tyr Gly Ala Gly Val
         295                 300                 305

 gcc aga gac cca ggg ttc cgc agc aac ttc cga cgg cag aac ggt gct     1015
 Ala Arg Asp Pro Gly Phe Arg Ser Asn Phe Arg Arg Gln Asn Gly Ala
     310                 315                 320

 gct ctg act tca gcc tcc atc ctg gcc cag cag gtg tgg gga acc ctt     1063
 Ala Leu Thr Ser Ala Ser Ile Leu Ala Gln Gln Val Trp Gly Thr Leu
 325                 330                 335                 340

 gtc ctt cta cag agg ctg gag cca gta cac ctc cag ctt cag tgc atg     1111
 Val Leu Leu Gln Arg Leu Glu Pro Val His Leu Gln Leu Gln Cys Met
                 345                 350                 355

 agc caa gaa cag ctg gcc cag gtg gct gcc aat gct acc aag gaa ttc     1159
 Ser Gln Glu Gln Leu Ala Gln Val Ala Ala Asn Ala Thr Lys Glu Phe
             360                 365                 370

 act gag gcc ttc ctg gga tgc ccg gcc atc cac ccc cgc tgc cgc tgg     1207
 Thr Glu Ala Phe Leu Gly Cys Pro Ala Ile His Pro Arg Cys Arg Trp
         375                 380                 385

 gga gcg gcg cct tat cgg ggc cgc ccg aag ctg ctg cag ctg ccg ctg     1255
 Gly Ala Ala Pro Tyr Arg Gly Arg Pro Lys Leu Leu Gln Leu Pro Leu
     390                 395                 400

 gga ttc ttg tac gtg cat cac acc tac gtg cct gca cca ccc tgc acg     1303
 Gly Phe Leu Tyr Val His His Thr Tyr Val Pro Ala Pro Pro Cys Thr
 405                 410                 415                 420

 gac ttc acg cgc tgc gca gcc aac atg cgc tcc atg cag cgc tac cac     1351
 Asp Phe Thr Arg Cys Ala Ala Asn Met Arg Ser Met Gln Arg Tyr His
                 425                 430                 435

 cag gac acg caa ggc tgg gga gac atc ggc tac agt ttc gtg gtg ggc     1399
 Gln Asp Thr Gln Gly Trp Gly Asp Ile Gly Tyr Ser Phe Val Val Gly
             440                 445                 450

 tcg gac ggc tac gtg tac gag gga cgc ggc tgg cac tgg gtg ggc gcc     1447
 Ser Asp Gly Tyr Val Tyr Glu Gly Arg Gly Trp His Trp Val Gly Ala
         455                 460                 465

 cac acg ctc ggc cac aac tcc cgg ggc ttc ggc gtg gcc ata gtg ggc     1495
 His Thr Leu Gly His Asn Ser Arg Gly Phe Gly Val Ala Ile Val Gly
     470                 475                 480

 aac tac acc gcg gcg ctg ccc acc gag gcc gct ctg cgc acg gtg cgc     1543
 Asn Tyr Thr Ala Ala Leu Pro Thr Glu Ala Ala Leu Arg Thr Val Arg
 485                 490                 495                 500

 gac acg ctc ccg agt tgt gcg gtg cgc gcc ggc ctc ctg cgg cca gac     1591
 Asp Thr Leu Pro Ser Cys Ala Val Arg Ala Gly Leu Leu Arg Pro Asp
                 505                 510                 515

 tac gcg ctg ctg ggc cac cgc cag ctg gtg cgc acc gac tgc ccc ggc     1639
 Tyr Ala Leu Leu Gly His Arg Gln Leu Val Arg Thr Asp Cys Pro Gly
             520                 525                 530

 gac gcg ctc ttc gac ctg ctg cgc acc tgg ccg cac ttc acc gcg act     1687
 Asp Ala Leu Phe Asp Leu Leu Arg Thr Trp Pro His Phe Thr Ala Thr
         535                 540                 545

 gtt aag cca aga cct gcc agg agt gtc tct aag aga tcc agg agg gag     1735
 Val Lys Pro Arg Pro Ala Arg Ser Val Ser Lys Arg Ser Arg Arg Glu
     550                 555                 560

 cca ccc cca agg acc ctg cca gcc aca gac ctc caa taa agacagcatg      1784
 Pro Pro Pro Arg Thr Leu Pro Ala Thr Asp Leu Gln 
 565                 570                 575

 gaaaaaaaaa aaaaaaaaag atttgcggcc caagctatcc ctttagta                1832




      <210> 25
      <211> 1046
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (68)..(595)

      <400> 25
 gagcagagcc tggggccaga gggccagaca gccacagagc tcctggcgtg ggcaaggctg     60

 gccaagg  atg gcg acg ccc agg ggc ctg gtg gcc ctg ctc ctg ctc ctc     109
          Met Ala Thr Pro Arg Gly Leu Val Ala Leu Leu Leu Leu Leu
            1               5                  10

 ctg ctc ccg acc tca ggt cag gaa aag ccc acc gaa ggg cca aga aac      157
 Leu Leu Pro Thr Ser Gly Gln Glu Lys Pro Thr Glu Gly Pro Arg Asn
  15                  20                  25                  30

 acc tgc ctg ggg agc aac aac atg tac gac atc ttc aac ttg aat gac      205
 Thr Cys Leu Gly Ser Asn Asn Met Tyr Asp Ile Phe Asn Leu Asn Asp
                  35                  40                  45

 aag gct ttg tgc ttc acc aag tgc agg cag tcg ggc agc gac tcc tgc      253
 Lys Ala Leu Cys Phe Thr Lys Cys Arg Gln Ser Gly Ser Asp Ser Cys
              50                  55                  60

 aat gtg gaa aac ttg cag aga tac tgg cta aac tac gag gcc cat ctg      301
 Asn Val Glu Asn Leu Gln Arg Tyr Trp Leu Asn Tyr Glu Ala His Leu
          65                  70                  75

 atg aag gaa ggt ttg acg cag aag gtg aac acg cct ttc ctg aag gct      349
 Met Lys Glu Gly Leu Thr Gln Lys Val Asn Thr Pro Phe Leu Lys Ala
      80                  85                  90

 ttg gtc cag aac ctc agc acc aac act gca gaa gac ttc tat ttc tct      397
 Leu Val Gln Asn Leu Ser Thr Asn Thr Ala Glu Asp Phe Tyr Phe Ser
  95                 100                 105                 110

 ctg gag ccc tct cag gtt ccg agg cag gtg atg aag gac gag gac aag      445
 Leu Glu Pro Ser Gln Val Pro Arg Gln Val Met Lys Asp Glu Asp Lys
                 115                 120                 125

 ccc cct gac aga gtg cga ctt ccc aag agc ctt ttt cga tcc ctg cca      493
 Pro Pro Asp Arg Val Arg Leu Pro Lys Ser Leu Phe Arg Ser Leu Pro
             130                 135                 140

 ggc aac agg tct gtg gtc cgc ttg gcc gtc acc att ctg gac att ggt      541
 Gly Asn Arg Ser Val Val Arg Leu Ala Val Thr Ile Leu Asp Ile Gly
         145                 150                 155

 cca ggg act ctc ttc aag gtg agg act cag gga agc tcc aag gtt aag      589
 Pro Gly Thr Leu Phe Lys Val Arg Thr Gln Gly Ser Ser Lys Val Lys
     160                 165                 170

 tgc tag gtcctctggg ggctccatgc cacagtttgc tgtcactgga gcctgccgag       645
 Cys 
 175

 ggatccaatg gggacagagc aggcagtgag cctcttagtg tttctaatgc agcccgtggc    705

 catctcagac acctgtcact agagtctatg gtcttcagac tcacactggt cacacgctct    765

 cagatgtttg acccccacac atgagtgccc tttggcttgt ctatgtgtcc tgtgggtgct    825

 cgtgtgctct gtgtgtcctc gtgcatgcac aaacatgcac atccttttct attcttgtgc    885

 acgcacaagc ccatgtactc agctgtgatc atatccacac gagcaagtgt acccatgccc    945

 ttgcacatgt gtataccagg tatgtgcacc cagaggtgtg catccactcc tgtgcagacg   1005

 tgtgtacccc tgagggctag tgtgctcccc ccaccctgta t                       1046




      <210> 26
      <211> 864
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (1)..(864)

      <400> 26
  atg ttt gct tgc ttt tgg ggc cct tct caa gcc aga tct cta acg tgg      48
  Met Phe Ala Cys Phe Trp Gly Pro Ser Gln Ala Arg Ser Leu Thr Trp
    1               5                  10                  15

 atg gag tgg cgc gtt tca ggg tgg ggc tat gac aat gca ctg cct gtg       96
 Met Glu Trp Arg Val Ser Gly Trp Gly Tyr Asp Asn Ala Leu Pro Val
              20                  25                  30

 cag ccg cca tca ccg cgc ccc ctc cac cgg ctc cgc agt ctc ctg ccc      144
 Gln Pro Pro Ser Pro Arg Pro Leu His Arg Leu Arg Ser Leu Leu Pro
          35                  40                  45

 ggc ttt ccc ttc tcc acc tcc atc tct gcg gag cgc tac gac gac atg      192
 Gly Phe Pro Phe Ser Thr Ser Ile Ser Ala Glu Arg Tyr Asp Asp Met
      50                  55                  60

 gcc tcc gct atg aag gcg gtg aca gag ctg aat gaa cct ctc tcc aat      240
 Ala Ser Ala Met Lys Ala Val Thr Glu Leu Asn Glu Pro Leu Ser Asn
  65                  70                  75                  80

 gaa gat cga aat ctc ctc tct gtg gcc tac aag aat gtg gtt ggt gcc      288
 Glu Asp Arg Asn Leu Leu Ser Val Ala Tyr Lys Asn Val Val Gly Ala
                  85                  90                  95

 agg cga tct tcc tgg agg gtc att agc agc att gag cag aaa acc atg      336
 Arg Arg Ser Ser Trp Arg Val Ile Ser Ser Ile Glu Gln Lys Thr Met
             100                 105                 110

 gct gat gga aac gaa aag aaa ttg gag aaa gtt aaa gct tac cgg gag      384
 Ala Asp Gly Asn Glu Lys Lys Leu Glu Lys Val Lys Ala Tyr Arg Glu
         115                 120                 125

 aag att gag aag gag ctg gag aca gtt tgc aat gat gtc ctg tct ctg      432
 Lys Ile Glu Lys Glu Leu Glu Thr Val Cys Asn Asp Val Leu Ser Leu
     130                 135                 140

 ctt gac aag ttc ctg atc aag aac tgc aat gat ttc cag tat gag agc      480
 Leu Asp Lys Phe Leu Ile Lys Asn Cys Asn Asp Phe Gln Tyr Glu Ser
 145                 150                 155                 160

 aag gtg ttt tac ctg aaa atg aag ggt gat tac tac cgc tac tta gca      528
 Lys Val Phe Tyr Leu Lys Met Lys Gly Asp Tyr Tyr Arg Tyr Leu Ala
                 165                 170                 175

 gag gtc gct tct ggg gag aag aaa aac agt gtg gtc gaa gct tct gaa      576
 Glu Val Ala Ser Gly Glu Lys Lys Asn Ser Val Val Glu Ala Ser Glu
             180                 185                 190

 gct gcc tac aag gaa gcc ttt gaa atc agc aaa gag cag atg caa ccc      624
 Ala Ala Tyr Lys Glu Ala Phe Glu Ile Ser Lys Glu Gln Met Gln Pro
         195                 200                 205

 acg cat ccc atc cgg ctg ggc ctg gcc ctc aac ttc tcc gtg ttc tac      672
 Thr His Pro Ile Arg Leu Gly Leu Ala Leu Asn Phe Ser Val Phe Tyr
     210                 215                 220

 tat gag atc cag aat gca cct gca cga acc ccc ctt cta gac caa aaa      720
 Tyr Glu Ile Gln Asn Ala Pro Ala Arg Thr Pro Leu Leu Asp Gln Lys
 225                 230                 235                 240

 gcc ctc ggc ttt cga aga gct gag ctg gac aca cta aac gag gat tcc      768
 Ala Leu Gly Phe Arg Arg Ala Glu Leu Asp Thr Leu Asn Glu Asp Ser
                 245                 250                 255

 tat aag gac tcc acg ctg atc atg cag ttg ctg cga gac aac ctc acc      816
 Tyr Lys Asp Ser Thr Leu Ile Met Gln Leu Leu Arg Asp Asn Leu Thr
             260                 265                 270

 ctc tgg acg agc gac cag cag gat gaa gaa gca gga gaa ggc aac tga      864
 Leu Trp Thr Ser Asp Gln Gln Asp Glu Glu Ala Gly Glu Gly Asn 
         275                 280                 285





      <210> 27
      <211> 462
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (1)..(462)

      <400> 27
  atg acc gtc tct gtt aca gga aag gtt tgg cgc ttt cta atc tca ctc      48
  Met Thr Val Ser Val Thr Gly Lys Val Trp Arg Phe Leu Ile Ser Leu
    1               5                  10                  15

 atg ttc aaa gaa ctc gtg gca ggc agt agt aac cat ggc aac aaa ggc       96
 Met Phe Lys Glu Leu Val Ala Gly Ser Ser Asn His Gly Asn Lys Gly
              20                  25                  30

 cat gaa ttc ctg gaa gtc aca ttc gcc gtc tcc atc att gtc cag tgt      144
 His Glu Phe Leu Glu Val Thr Phe Ala Val Ser Ile Ile Val Gln Cys
          35                  40                  45

 ttc cat gac ttt gtc cac aac ctc ctg ctc ttt gat ttc atg tct gag      192
 Phe His Asp Phe Val His Asn Leu Leu Leu Phe Asp Phe Met Ser Glu
      50                  55                  60

 ctg gag aag gcc atg gtg gcc ctc atc gac gtt ttc cac caa tat tct      240
 Leu Glu Lys Ala Met Val Ala Leu Ile Asp Val Phe His Gln Tyr Ser
  65                  70                  75                  80

 gga agg gag gga gac aag cac aag ctg aag aaa tcc gaa ctg aag gag      288
 Gly Arg Glu Gly Asp Lys His Lys Leu Lys Lys Ser Glu Leu Lys Glu
                  85                  90                  95

 ctc atc aac aat gag ctt tcc cat ttc tta gag gaa atc aaa gag cag      336
 Leu Ile Asn Asn Glu Leu Ser His Phe Leu Glu Glu Ile Lys Glu Gln
             100                 105                 110

 gag gtt gtg gac aaa gtc atg gaa aca ctg gac aat gat gga gac ggc      384
 Glu Val Val Asp Lys Val Met Glu Thr Leu Asp Asn Asp Gly Asp Gly
         115                 120                 125

 gaa tgt gac ttc cag gaa ttc atg gcc ttt gtt gcc atg gtt act act      432
 Glu Cys Asp Phe Gln Glu Phe Met Ala Phe Val Ala Met Val Thr Thr
     130                 135                 140

 gcc tgc cac gag ttc ttt gaa cat gag tga                              462
 Ala Cys His Glu Phe Phe Glu His Glu 
 145                 150





      <210> 28
      <211> 645
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (204)..(449)

      <400> 28
 tgggggttta gcgggtaaga ttgacacaga acgagtagtg cgtgatggcg aattgaatac     60

 gagtgactat ggggaatgtg cgctgaaggc caagaatggg ggacgagggc gtccgagctc    120

 gagggcagct ctggggcaga actgtccgga tctaacaatc cctggggagc cggagaccgg    180

 tgactgccgc cctggccgca gcc    atg tgg ccc acg ctg ttg ctg ctg ctg     230
                              Met Trp Pro Thr Leu Leu Leu Leu Leu
                                1               5

 atg ctg ttc cgg gcc gcc ccg gtc ccc acc gcc aaa gcc gct ccc cac      278
 Met Leu Phe Arg Ala Ala Pro Val Pro Thr Ala Lys Ala Ala Pro His
  10                  15                  20                  25

 ccg gat gct aac acc cag gaa ggc ctt cag aac ctg ctc caa gga gtc      326
 Pro Asp Ala Asn Thr Gln Glu Gly Leu Gln Asn Leu Leu Gln Gly Val
                  30                  35                  40

 ggg gct ggc gga gac gga gag ctg cgg gca gac tca cac ctg gcc ccg      374
 Gly Ala Gly Gly Asp Gly Glu Leu Arg Ala Asp Ser His Leu Ala Pro
              45                  50                  55

 ggc tct ggc tgt att gat ggg gct gtg gtg gcc acg cga cca gaa agc      422
 Gly Ser Gly Cys Ile Asp Gly Ala Val Val Ala Thr Arg Pro Glu Ser
          60                  65                  70

 cgg gga gga aag act gcg gtt ccg tga gaggc gtccagggct gcaggccacg      474
 Arg Gly Gly Lys Thr Ala Val Pro 
      75                  80

 gcgacaggct ccggggaaca tggggctttc cctgtccact cccaaggagt gtgggcctca    534

 acgcattggc aggggacggc cgtgtgccct ctccagaccc cacccccaga tgcatttatt    594

 agaaataata aagttctttc ttagctaaaa aaaaaaaaaa aaaaaaaatt g             645




      <210> 29
      <211> 2975
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (196)..(2322)

      <400> 29
 gggaactggc aggcgtttca gagcgtcaga ggctgcggat gagcagactt ggaggactcc     60

 aggccagaga ctaggctggg cgaagagtcg agcgtgaagg gggctccggg ccagggtgac    120

 aggaggcgtg cttgagagga agaagttgac gggaaggcca gtgcgacggc aaatctcgtg    180

 aaccttgggg gacga atg ctc agg atg cgg gtc ccc gcc ctc ctc gtc ctc     231
                  Met Leu Arg Met Arg Val Pro Ala Leu Leu Val Leu
                    1               5                  10

 ctc ttc tgc ttc aga ggg aga gca ggc ccg tcg ccc cat ttc ctg caa      279
 Leu Phe Cys Phe Arg Gly Arg Ala Gly Pro Ser Pro His Phe Leu Gln
          15                  20                  25

 cag cca gag gac ctg gtg gtg ctg ctg ggg gag gaa gcc cgg ctg ccg      327
 Gln Pro Glu Asp Leu Val Val Leu Leu Gly Glu Glu Ala Arg Leu Pro
      30                  35                  40

 tgt gct ctg ggc gcc tac tgg ggg cta gtt cag tgg act aag agt ggg      375
 Cys Ala Leu Gly Ala Tyr Trp Gly Leu Val Gln Trp Thr Lys Ser Gly
  45                  50                  55                  60

 ctg gcc cta ggg ggc caa agg gac cta cca ggg tgg tcc cgg tac tgg      423
 Leu Ala Leu Gly Gly Gln Arg Asp Leu Pro Gly Trp Ser Arg Tyr Trp
                  65                  70                  75

 ata tca ggg aat gca gcc aat ggc cag cat gac ctc cac att agg ccc      471
 Ile Ser Gly Asn Ala Ala Asn Gly Gln His Asp Leu His Ile Arg Pro
              80                  85                  90

 gtg gag cta gag gat gaa gca tca tat gaa tgt cag gct aca caa gca      519
 Val Glu Leu Glu Asp Glu Ala Ser Tyr Glu Cys Gln Ala Thr Gln Ala
          95                 100                 105

 ggc ctc cgc tcc aga cca gcc caa ctg cac gtg ctg gtc ccc cca gaa      567
 Gly Leu Arg Ser Arg Pro Ala Gln Leu His Val Leu Val Pro Pro Glu
     110                 115                 120

 gcc ccc cag gtg ctg ggc ggc ccc tct gtg tct ctg gtt gct gga gtt      615
 Ala Pro Gln Val Leu Gly Gly Pro Ser Val Ser Leu Val Ala Gly Val
 125                 130                 135                 140

 cct gcg aac ctg aca tgt cgg agc cgt ggg gat gcc cgc cct acc cct      663
 Pro Ala Asn Leu Thr Cys Arg Ser Arg Gly Asp Ala Arg Pro Thr Pro
                 145                 150                 155

 gaa ttg ctg tgg ttc cga gat ggg gtc ctg ttg gat gga gcc acc ttc      711
 Glu Leu Leu Trp Phe Arg Asp Gly Val Leu Leu Asp Gly Ala Thr Phe
             160                 165                 170

 cat cag acc ctg ctg aag gaa ggg acc cct ggg tca gtg gag agc acc      759
 His Gln Thr Leu Leu Lys Glu Gly Thr Pro Gly Ser Val Glu Ser Thr
         175                 180                 185

 tta acc ctg acc cct ttc agc cat gat gat gga gcc acc ttt gtc tgc      807
 Leu Thr Leu Thr Pro Phe Ser His Asp Asp Gly Ala Thr Phe Val Cys
     190                 195                 200

 cgg gcc cgg agc cag gcc ctg ccc aca gga aga gac aca gct atc aca      855
 Arg Ala Arg Ser Gln Ala Leu Pro Thr Gly Arg Asp Thr Ala Ile Thr
 205                 210                 215                 220

 ctg agc ctg cag tac ccc cca gag gtg act ctg tct gct tcg cca cac      903
 Leu Ser Leu Gln Tyr Pro Pro Glu Val Thr Leu Ser Ala Ser Pro His
                 225                 230                 235

 act gtg cag gag gga gag aag gtc att ttc ctg tgc cag gcc aca gcc      951
 Thr Val Gln Glu Gly Glu Lys Val Ile Phe Leu Cys Gln Ala Thr Ala
             240                 245                 250

 cag cct cct gtc aca ggc tac agg tgg gca aaa ggg ggc tct ccg gtg      999
 Gln Pro Pro Val Thr Gly Tyr Arg Trp Ala Lys Gly Gly Ser Pro Val
         255                 260                 265

 ctc ggg gcc cgc ggg cca agg tta gag gtc gtg gca gac gcc tcg ttc     1047
 Leu Gly Ala Arg Gly Pro Arg Leu Glu Val Val Ala Asp Ala Ser Phe
     270                 275                 280

 ctg act gag ccc gtg tcc tgc gag gtc agc aac gcc gtg ggt agc gcc     1095
 Leu Thr Glu Pro Val Ser Cys Glu Val Ser Asn Ala Val Gly Ser Ala
 285                 290                 295                 300

 aac cgc agt act gcg ctg gat gtg ctg ttt ggg ccg att ctg cag gca     1143
 Asn Arg Ser Thr Ala Leu Asp Val Leu Phe Gly Pro Ile Leu Gln Ala
                 305                 310                 315

 aag ccg gag ccc gtg tcc gtg gac gtg ggg gaa gac gct tcc ttc agc     1191
 Lys Pro Glu Pro Val Ser Val Asp Val Gly Glu Asp Ala Ser Phe Ser
             320                 325                 330

 tgc gcc tgg cgc ggg aac ccg ctt cca cgg gta acc tgg acc cgc cgc     1239
 Cys Ala Trp Arg Gly Asn Pro Leu Pro Arg Val Thr Trp Thr Arg Arg
         335                 340                 345

 ggt ggc gcg cag gtg ctg ggc tct gga gcc aca ctg cgt ctt ccg tcg     1287
 Gly Gly Ala Gln Val Leu Gly Ser Gly Ala Thr Leu Arg Leu Pro Ser
     350                 355                 360

 gtg ggg ccc gag gac gca ggc gac tat gtg tgc aga gct gag gct ggg     1335
 Val Gly Pro Glu Asp Ala Gly Asp Tyr Val Cys Arg Ala Glu Ala Gly
 365                 370                 375                 380

 cta tcg ggc ctg cgg ggc ggc gcc gcg gag gct cgg ctg act gtg aac     1383
 Leu Ser Gly Leu Arg Gly Gly Ala Ala Glu Ala Arg Leu Thr Val Asn
                 385                 390                 395

 gct ccc cca gta gtg acc gcc ctg cac tct gcg cct gcc ttc ctg agg     1431
 Ala Pro Pro Val Val Thr Ala Leu His Ser Ala Pro Ala Phe Leu Arg
             400                 405                 410

 ggc cct gct cgc ctc cag tgt ctg gtt ttc gcc tct ccc gcc cca gat     1479
 Gly Pro Ala Arg Leu Gln Cys Leu Val Phe Ala Ser Pro Ala Pro Asp
         415                 420                 425

 gcc gtg gtc tgg tct tgg gat gag ggc ttc ctg gag gcg ggg tcg cag     1527
 Ala Val Val Trp Ser Trp Asp Glu Gly Phe Leu Glu Ala Gly Ser Gln
     430                 435                 440

 ggc cgg ttc ctg gtg gag aca ttc cct gcc cca gag agc cgc ggg gga     1575
 Gly Arg Phe Leu Val Glu Thr Phe Pro Ala Pro Glu Ser Arg Gly Gly
 445                 450                 455                 460

 ctg ggt ccg ggc ctg atc tct gtg cta cac att tcg ggg acc cag gag     1623
 Leu Gly Pro Gly Leu Ile Ser Val Leu His Ile Ser Gly Thr Gln Glu
                 465                 470                 475

 tct gac ttt agc agg agc ttt aac tgc agt gcc cgg aac cgg ctg ggc     1671
 Ser Asp Phe Ser Arg Ser Phe Asn Cys Ser Ala Arg Asn Arg Leu Gly
             480                 485                 490

 gag gga ggt gcc cag gcc agc ctg ggc cgt aga gac ttg ctg ccc act     1719
 Glu Gly Gly Ala Gln Ala Ser Leu Gly Arg Arg Asp Leu Leu Pro Thr
         495                 500                 505

 gtg cgg ata gtg gcc gga gtg gcc gct gcc acc aca act ctc ctt atg     1767
 Val Arg Ile Val Ala Gly Val Ala Ala Ala Thr Thr Thr Leu Leu Met
     510                 515                 520

 gtc atc act ggg gtg gcc ctc tgc tgc tgg cgc cac agc aag gcc tca     1815
 Val Ile Thr Gly Val Ala Leu Cys Cys Trp Arg His Ser Lys Ala Ser
 525                 530                 535                 540

 gcc tct ttc tcc gag caa aag aac ctg atg cga atc cct ggc agc agc     1863
 Ala Ser Phe Ser Glu Gln Lys Asn Leu Met Arg Ile Pro Gly Ser Ser
                 545                 550                 555

 gac ggc tcc agt tca cga ggt cct gaa gaa gag gag aca ggc agc cgc     1911
 Asp Gly Ser Ser Ser Arg Gly Pro Glu Glu Glu Glu Thr Gly Ser Arg
             560                 565                 570

 gag gac cgg ggc ccc att gtg cac act gac cac agt gat ctg gtt ctg     1959
 Glu Asp Arg Gly Pro Ile Val His Thr Asp His Ser Asp Leu Val Leu
         575                 580                 585

 gag gag gaa ggg act ctg gag acc aag gac cca acc aac ggt tac tac     2007
 Glu Glu Glu Gly Thr Leu Glu Thr Lys Asp Pro Thr Asn Gly Tyr Tyr
     590                 595                 600

 aag gtc cga gga gtc agt gtg agc ctg agc ctt ggc gaa gcc cct gga     2055
 Lys Val Arg Gly Val Ser Val Ser Leu Ser Leu Gly Glu Ala Pro Gly
 605                 610                 615                 620

 gga ggt ctc ttc ctg cca cca ccc tcc ccc ctt ggg ccc cca ggg acc     2103
 Gly Gly Leu Phe Leu Pro Pro Pro Ser Pro Leu Gly Pro Pro Gly Thr
                 625                 630                 635

 cct acc ttc tat gac ttc aac cca cac ctg ggc atg gtc ccc ccc tgc     2151
 Pro Thr Phe Tyr Asp Phe Asn Pro His Leu Gly Met Val Pro Pro Cys
             640                 645                 650

 aga ctt tac aga gcc agg gca ggc tat ctc acc aca ccc cac cct cga     2199
 Arg Leu Tyr Arg Ala Arg Ala Gly Tyr Leu Thr Thr Pro His Pro Arg
         655                 660                 665

 gct ttc acc agc tac atc aaa ccc aca tcc ttt ggg ccc cca gat ctg     2247
 Ala Phe Thr Ser Tyr Ile Lys Pro Thr Ser Phe Gly Pro Pro Asp Leu
     670                 675                 680

 gcc ccc ggg act ccc ccc ttc cca tat gct gcc ttc ccc aca cct agc     2295
 Ala Pro Gly Thr Pro Pro Phe Pro Tyr Ala Ala Phe Pro Thr Pro Ser
 685                 690                 695                 700

 cac ccg cgt ctc cag act cac gtg tga catct ttccaatgga agagtcctgg     2347
 His Pro Arg Leu Gln Thr His Val 
                 705

 gatctccaac ttgccataat ggattgttct gatttctgag gagccaggac aagttggcga   2407

 ccttactcct ccaaaactga acacaagggg agggaaagat cattacattt gtcaggagca   2467

 tttgtataca gtcagctcag ccaaaggaga tgccccaagt gggagcaaca tggccaccca   2527

 atatgcccac ctattccccg gtgtaaaaga gattcaagat ggcaggtagg ccctttgagg   2587

 agagatgggg acagggcagt gggtgttggg agtttggggc cgggatggaa gttgtttcta   2647

 gccactgaaa gaagatattt caagatgacc atctgcattg agaggaaagg tagcatagga   2707

 tagatgaaga tgaagagcat accaggcccc accctggctc tccctgaggg gaactttgct   2767

 cggccaatgg aaatgcagcc aagatggcca tatactccct aggaacccaa gatggccacc   2827

 atcttgattt tactttcctt aaagactcag aaagacttgg acccaaggag tggggataca   2887

 gtgagaatta ccactgttgg ggcaaaatat tgggataaaa atatttatgt ttaataataa   2947

 aaaaaagtca aaaaaaaaaa aaaaaaaa                                      2975




      <210> 30
      <211> 2565
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (1217)..(2422)

      <400> 30
 atgaatggga agaataagac caacatttat caagagccga ctgtatgcca ggcactgcat     60

 tggaccctgg cacggatagg aaaggaggag ccgcggcgcg ggcagcgggg cgaggggctt    120

 ctgtgctcgc gggagcggca gcccaggggg ctcagcagcc ccggcaccgc cgcacctgcg    180

 gctccagcag ccccaacccc gccagcgctg cctggccacc gtacccgaag cggctccccc    240

 cgagggcccc gagcctatcc tacgccgggg cggctccgcg gacgcgccgg gccgagtcaa    300

 gacctgggtc aaccgccctg cagcctttgt agggaagtgc ctaggtgatg ggtctgctga    360

 taccgcctgt gaccaggcca tgaagggcca gaggggctcc aatcgcaagc gcaaaacctc    420

 gcacagcctc acgtttccca ccagctcaga catgcacgct ggcggacttt cagcggctca    480

 cccgtgtgca cactcacgtg cccccccccc cgcttcccca agcccgtaca aaggcagcct    540

 gggcacacgg acagacggac tgacggactc tcgagcggac agcgcagcta gcggggcgcg    600

 ggcgctgggc gtcgacggcc agccccagcc ttccccgccc cgtcgcgccc cgccccgtcc    660

 cgtcggggcc gatggctcct cccgaggccc gcagcccggg cggcgcaggg tagagcgccg    720

 cggcccggcc acgcagcccg gggactcccg ggccctcccg gagccccgcg gggtccccgc    780

 cgtgcatccg gcgggctcag ggagcgagtg ggagcgccct ccccccgctg ccccctcccc    840

 cgagcatcga gacaagatgc tgcccgggct caggcgcctg ctgcaagcat ctgcccgcag    900

 gccccagccc ttccctgaag cagcccgttg ggtgtggagc ccttgcttct cgtctgggac    960

 cctgtgcccc tccttccaga gcgagaggcc tctgctgcct ttccagggag catcctttcc   1020

 tgggaccact ctgcaccagc gactctgccc tgtggctgct ttgcacggca gtggcaaggg   1080

 ccagaaatgg caacagagtc actgttatgc agcagctgtt atggaggagc ccccagcacc   1140

 gggtcgctct tcagagagcc tgcagggacc actatcatgg gctgggggag ctcccgcctc   1200

 ggcctgcctc ctgctg    atg ctc ctg gcc ctg ccc ctg gcg gcc ccc agc    1249
                      Met Leu Leu Ala Leu Pro Leu Ala Ala Pro Ser
                        1               5                  10

 tgc ccc atg ctc tgc acc tgc tac tca tcc ccg ccc acc gtg agc tgc     1297
 Cys Pro Met Leu Cys Thr Cys Tyr Ser Ser Pro Pro Thr Val Ser Cys
              15                  20                  25

 cag gcc aac aac ttc tcc tct gtg ccg ctg tcc ctg cca ccc agc act     1345
 Gln Ala Asn Asn Phe Ser Ser Val Pro Leu Ser Leu Pro Pro Ser Thr
          30                  35                  40

 cag cga ctc ttc ctg cag aac aac ctc atc cgc acg ctg cgg cca ggc     1393
 Gln Arg Leu Phe Leu Gln Asn Asn Leu Ile Arg Thr Leu Arg Pro Gly
      45                  50                  55

 acc ttt ggg tcc aac ctg ctc acc ctg tgg ctc ttc tcc aac aac ctc     1441
 Thr Phe Gly Ser Asn Leu Leu Thr Leu Trp Leu Phe Ser Asn Asn Leu
  60                  65                  70                  75

 tcc acc atc tac ccg ggc act ttc cgc cac ttg caa gcc ctg gag gag     1489
 Ser Thr Ile Tyr Pro Gly Thr Phe Arg His Leu Gln Ala Leu Glu Glu
                  80                  85                  90

 ctg gac ctc ggt gac aac cgg cac ctg cgc tcg ctg gag ccc gac acc     1537
 Leu Asp Leu Gly Asp Asn Arg His Leu Arg Ser Leu Glu Pro Asp Thr
              95                 100                 105

 ttc cag ggc ctg gag cgg ctg cag tcg ctg cat ttg tac cgc tgc cag     1585
 Phe Gln Gly Leu Glu Arg Leu Gln Ser Leu His Leu Tyr Arg Cys Gln
         110                 115                 120

 ctc agc agc ctg ccc ggc aac atc ttc cga ggc ctg gtc agc ctg cag     1633
 Leu Ser Ser Leu Pro Gly Asn Ile Phe Arg Gly Leu Val Ser Leu Gln
     125                 130                 135

 tac ctc tac ctc cag gag aac agc ctg ctc cac cta cag gat gac ttg     1681
 Tyr Leu Tyr Leu Gln Glu Asn Ser Leu Leu His Leu Gln Asp Asp Leu
 140                 145                 150                 155

 ttc gcg gac ctg gcc aac ctg agc cac ctc ttc ctc cac ggg aac cgc     1729
 Phe Ala Asp Leu Ala Asn Leu Ser His Leu Phe Leu His Gly Asn Arg
                 160                 165                 170

 ctg cgg ctg ctc aca gag cac gtg ttt cgc ggc ctg ggc agc ctg gac     1777
 Leu Arg Leu Leu Thr Glu His Val Phe Arg Gly Leu Gly Ser Leu Asp
             175                 180                 185

 cgg ctg ctg ctg cac ggg aac cgg ctg cag ggc gtg cac cgc gcg gcc     1825
 Arg Leu Leu Leu His Gly Asn Arg Leu Gln Gly Val His Arg Ala Ala
         190                 195                 200

 ttc cgc ggc ctc agc cgc ctc acc atc ctc tac ctg ttc aac aac agc     1873
 Phe Arg Gly Leu Ser Arg Leu Thr Ile Leu Tyr Leu Phe Asn Asn Ser
     205                 210                 215

 ctg gcc tcg ctg ccc ggc gag gcg ctc gcc gac ctg ccc tcg ctc gag     1921
 Leu Ala Ser Leu Pro Gly Glu Ala Leu Ala Asp Leu Pro Ser Leu Glu
 220                 225                 230                 235

 ttc ctg cgg ctc aac gct aac ccc tgg gcg tgc gac tgc cgc gcg cgg     1969
 Phe Leu Arg Leu Asn Ala Asn Pro Trp Ala Cys Asp Cys Arg Ala Arg
                 240                 245                 250

 ccg ctc tgg gcc tgg ttc cag cgc gcg cgc gtg tcc agc tcc gac gtg     2017
 Pro Leu Trp Ala Trp Phe Gln Arg Ala Arg Val Ser Ser Ser Asp Val
             255                 260                 265

 acc tgc gcc acc ccc ccg gag cgc cag ggc cga gac ctg cgc gcg ctc     2065
 Thr Cys Ala Thr Pro Pro Glu Arg Gln Gly Arg Asp Leu Arg Ala Leu
         270                 275                 280

 cgc gag gcc gac ttc cag gcg tgt ccg ccc gcg gca ccc acg cgg ccg     2113
 Arg Glu Ala Asp Phe Gln Ala Cys Pro Pro Ala Ala Pro Thr Arg Pro
     285                 290                 295

 ggc agc cgc gcc cgc ggc aac agc tcc tcc aac cac ctg tac ggg gtg     2161
 Gly Ser Arg Ala Arg Gly Asn Ser Ser Ser Asn His Leu Tyr Gly Val
 300                 305                 310                 315

 gcc gag gcc ggg gcg ccc cca gcc gat ccc tcc acc ctc tac cga gat     2209
 Ala Glu Ala Gly Ala Pro Pro Ala Asp Pro Ser Thr Leu Tyr Arg Asp
                 320                 325                 330

 ctg cct gcc gaa gac tcg cgg ggg cgc cag ggc ggg gac gcg cct act     2257
 Leu Pro Ala Glu Asp Ser Arg Gly Arg Gln Gly Gly Asp Ala Pro Thr
             335                 340                 345

 gag gac gac tac tgg ggg ggc tac ggg ggt gag gac cag cga ggg gag     2305
 Glu Asp Asp Tyr Trp Gly Gly Tyr Gly Gly Glu Asp Gln Arg Gly Glu
         350                 355                 360

 cag atg tgc ccc ggc gct gcc tgc cag gcg ccc ccg gac tcc cga ggc     2353
 Gln Met Cys Pro Gly Ala Ala Cys Gln Ala Pro Pro Asp Ser Arg Gly
     365                 370                 375

 cct gcg ctc tcg gcc ggg ctc ccc agc cct ctg ctt tgc ctc ctg ctc     2401
 Pro Ala Leu Ser Ala Gly Leu Pro Ser Pro Leu Leu Cys Leu Leu Leu
 380                 385                 390                 395

 ctg gtg ccc cac cac ctc tga ct gcggtgctga gatcgaagag gccagtgtcc     2454
 Leu Val Pro His His Leu 
                 400

 gatccccgct tcccgtccac ccggggctgc ggctccggcc ccagtcgccc caccttccct   2514

 ggccttgctg cctccctttc ccctcccagc tcctctcctc cccggagagc g            2565




      <210> 31
      <211> 1904
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (268)..(750)

      <400> 31
 ggtttttttt tttttttttt agaaaaacat agcatattga atcatcacaa ggcagccacc     60

 ccttcatagc cacacctggc ccctggccac cactgacctg tgctccatca ccagaattcc    120

 gttgtctcag gaatgttcga tgaatggaat cctgtgtggc ctgagatgag tgtctttcat    180

 gccacgtgac acccttgagg tccgtgcaag ctgttggcat gtcaacagtt agctgcttct    240

 cattgctgag tggcgattgg tcctgtc    atg gtt tat tca gcc atg tgg tgg     291
                                  Met Val Tyr Ser Ala Met Trp Trp
                                    1               5

 atg gct act tgt ctt cta agc cac ttg cct tct gat tgc tgg act gac      339
 Met Ala Thr Cys Leu Leu Ser His Leu Pro Ser Asp Cys Trp Thr Asp
      10                  15                  20

 tct ctc gcc ctc tct tgg tgc agc cct cgg gag gct cag tca cac tct      387
 Ser Leu Ala Leu Ser Trp Cys Ser Pro Arg Glu Ala Gln Ser His Ser
  25                  30                  35                  40

 ccg aga gca cag cca tca tct ccc acg aca tca cag gcc tgg tca cat      435
 Pro Arg Ala Gln Pro Ser Ser Pro Thr Thr Ser Gln Ala Trp Ser His
                  45                  50                  55

 gag atg ctg ccc tct acc tgg cag aat ggg cca tcg aga acc cgg cag      483
 Glu Met Leu Pro Ser Thr Trp Gln Asn Gly Pro Ser Arg Thr Arg Gln
              60                  65                  70

 cct tct ctc ata ggt gac ctc ggg gcg cac ggc agg aca ccg agg cag      531
 Pro Ser Leu Ile Gly Asp Leu Gly Ala His Gly Arg Thr Pro Arg Gln
          75                  80                  85

 gct cac cct ggt gca gtc aca gac atg gtc ccc ttt cct ccc gcc agg      579
 Ala His Pro Gly Ala Val Thr Asp Met Val Pro Phe Pro Pro Ala Arg
      90                  95                 100

 act gtc cta gag ctt ggc agt ggc gcc agc ctc aca ggc ctg gcc atc      627
 Thr Val Leu Glu Leu Gly Ser Gly Ala Ser Leu Thr Gly Leu Ala Ile
 105                 110                 115                 120

 tgc aag atg tgc cgc ctc cag gca tac atc ttc agc gac tgt cac agc      675
 Cys Lys Met Cys Arg Leu Gln Ala Tyr Ile Phe Ser Asp Cys His Ser
                 125                 130                 135

 cag gtc ctc gag aag ctc cga ggg aat gtc ctt ctc aat ggc ctc tca      723
 Gln Val Leu Glu Lys Leu Arg Gly Asn Val Leu Leu Asn Gly Leu Ser
             140                 145                 150

 tta gag gca gca tct ctg cca act tag acagc cccagggtga cagtggccca      775
 Leu Glu Ala Ala Ser Leu Pro Thr 
         155                 160

 gctggactgg gacgtcgcga cggtccatca gctctctgcc atccagccag atgttgtcat    835

 tgcagcaggc aatgcccagc cccgggcact ctgtgcaggc gacgtgctgt attgcccaga    895

 atccatcgtg tcgctggtcg cggtcctgcg gaggctggct gcctaccggg agcaccagcg    955

 ggctcctcaa gtctacgtgg cccttatcgt ccgcaaccca gagacgtgcc agctgttcac   1015

 caccgagcta tccaagcccg ctgcagctgc cacatctgtg gacacactcg gttcctcaca   1075

 aagccaagcc cgctgcagct gccacatcgg tggacacact cggttcctca caaagccaag   1135

 cccgctgcag ctgccacatc cctggacaca ctcggttcct cacaaagcca agcccactgc   1195

 agctgccaca tccctggaca cactcggttc ctcacaaagc caagcccgct gcagctgcca   1255

 catcggtgga cacactcggt tcttcacaaa gccaagcccg ctgcagctgc cacatcggtg   1315

 gacacactcg attcctcaca aagccaagcc cactgcagct gccacatccc tggacacact   1375

 cggttcttca caaagccaag cccgctgcag ctgccacatc cctggacaca ctcggttctt   1435

 cacaaagcca agcccgctgc agctgccaca tccctggaca cactcggttc ctcacaaagc   1495

 caagcccgct gcagctgcca catccctgga cacactcggt tcctcacaaa gccaagcccg   1555

 ctgcagctgc cacatcggtg gacacactcg gttcttcaca aagccaagcc cgctgcagct   1615

 gtcacatcgg tggacacact cggttcttca caaagccaag cccgctgcag ctgccacatc   1675

 ggtggacaca ctcgattcct cacaaagcca agcccactgc agctgccaca tccctggaca   1735

 cactcggttc ttcacaaagc caagcccgct gcagctgcca catccctgga cacactcggt   1795

 tcttcacaaa gccaagcccg ctgcagctgc cacatccctg ggcttatggt gcagcaggtg   1855

 cttttttcaa gacaggaatc aaaatgttag gaacacggca gaaaggtga               1904




      <210> 32
      <211> 650
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (105)..(590)

      <220>
      <221> misc_feature
      <222> (1)...(650)
      <223> n = a,t,c or g

      <400> 32
 cccacgcgta cgggctgtag gagttctgga gctgctggct ggagaggagg gtggacgaag     60

 ctctctctag aaagacatcc tgagaggact tggcaggcct gaac atg cat tgg ctg     116
                                                  Met His Trp Leu
                                                    1

 cga aaa gtt cag gga ctt tgc acc ctg tgg ggt act cag atg tcc agc      164
 Arg Lys Val Gln Gly Leu Cys Thr Leu Trp Gly Thr Gln Met Ser Ser
   5                  10                  15                  20

 cgc act ctc tac att aat agt agg caa ctg gtg tcc ctg cag tgg ggc      212
 Arg Thr Leu Tyr Ile Asn Ser Arg Gln Leu Val Ser Leu Gln Trp Gly
                  25                  30                  35

 cac cag gaa gtg ccg gcc aag ttt aac ttt gct agt gat gtg ttg gat      260
 His Gln Glu Val Pro Ala Lys Phe Asn Phe Ala Ser Asp Val Leu Asp
              40                  45                  50

 cac tgg gct gac atg gag aag gct ggc aag cga ctc cca agc cca gcc      308
 His Trp Ala Asp Met Glu Lys Ala Gly Lys Arg Leu Pro Ser Pro Ala
          55                  60                  65

 ctg tgg tgg gtg aat ggg aag ggg aag gaa tta atg tgg aat ttc aga      356
 Leu Trp Trp Val Asn Gly Lys Gly Lys Glu Leu Met Trp Asn Phe Arg
      70                  75                  80

 gaa ctg agt gaa aac agc cag cag gca gcc aac gtc ctc tcg gga gcc      404
 Glu Leu Ser Glu Asn Ser Gln Gln Ala Ala Asn Val Leu Ser Gly Ala
  85                  90                  95                 100

 tgt ggc ctg cag cgt ggg gat cgt gtg gca gtg atg ctg ccc cga gtg      452
 Cys Gly Leu Gln Arg Gly Asp Arg Val Ala Val Met Leu Pro Arg Val
                 105                 110                 115

 cct gag tgg tgg ctg gtg atc ctg ggc tgc att cga gca ggt ctc atc      500
 Pro Glu Trp Trp Leu Val Ile Leu Gly Cys Ile Arg Ala Gly Leu Ile
             120                 125                 130

 ttt atg cct gga acc atc cag atg aaa tcc act gac ata ctg tat aag      548
 Phe Met Pro Gly Thr Ile Gln Met Lys Ser Thr Asp Ile Leu Tyr Lys
         135                 140                 145

 ttg cag atg tct aag gcc aag gct att gtt gct ggg gga taa gtcatnc      597
 Leu Gln Met Ser Lys Ala Lys Ala Ile Val Ala Gly Gly 
     150                 155                 160

 cagaagtgga cacagtggca tnctgatgtn cttctctgag aattagctta ctg           650




      <210> 33
      <211> 1605
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (1)..(1605)

      <400> 33
  atg ggg gcg ggc ccc ggg cgg tgt ggg ggc ccc tgg gct ccc agg gtg      48
  Met Gly Ala Gly Pro Gly Arg Cys Gly Gly Pro Trp Ala Pro Arg Val
    1               5                  10                  15

 gga gct ggc tcc gag gct ggc tgg ctc cgc agg tcc gct gac gtc gcc       96
 Gly Ala Gly Ser Glu Ala Gly Trp Leu Arg Arg Ser Ala Asp Val Ala
              20                  25                  30

 gcc cag atg gcc tcc agg ctg acc ctg ctg acc ctc ctg ctg ctg ctg      144
 Ala Gln Met Ala Ser Arg Leu Thr Leu Leu Thr Leu Leu Leu Leu Leu
          35                  40                  45

 ctg gct ggg gat aga gcc tcc tca aat cca aat gct acc agc tcc agc      192
 Leu Ala Gly Asp Arg Ala Ser Ser Asn Pro Asn Ala Thr Ser Ser Ser
      50                  55                  60

 tcc cag gat cca gag agt ttg caa gac aga ggc gaa ggg aag gtc gca      240
 Ser Gln Asp Pro Glu Ser Leu Gln Asp Arg Gly Glu Gly Lys Val Ala
  65                  70                  75                  80

 aca aca gtt atc tcc aag atg cta ttc gtt gaa ccc atc ctg gag gtt      288
 Thr Thr Val Ile Ser Lys Met Leu Phe Val Glu Pro Ile Leu Glu Val
                  85                  90                  95

 tcc agc ttg ccg aca acc aac tca aca acc aat tca gcc acc aaa ata      336
 Ser Ser Leu Pro Thr Thr Asn Ser Thr Thr Asn Ser Ala Thr Lys Ile
             100                 105                 110

 aca gct aat acc act gat gaa ccc acc aca caa ccc acc aca gag ccc      384
 Thr Ala Asn Thr Thr Asp Glu Pro Thr Thr Gln Pro Thr Thr Glu Pro
         115                 120                 125

 acc acc caa ccc acc atc caa ccc acc caa cca act acc cag ctc cca      432
 Thr Thr Gln Pro Thr Ile Gln Pro Thr Gln Pro Thr Thr Gln Leu Pro
     130                 135                 140

 aca gat tct cct acc cag ccc act act ggg tcc ttc tgc cca gga cct      480
 Thr Asp Ser Pro Thr Gln Pro Thr Thr Gly Ser Phe Cys Pro Gly Pro
 145                 150                 155                 160

 gtt act ctc tgc tct gac ttg gag agt cat tca aca gag gcc gtg ttg      528
 Val Thr Leu Cys Ser Asp Leu Glu Ser His Ser Thr Glu Ala Val Leu
                 165                 170                 175

 ggg gat gct ttg gta gat ttc tcc ctg aag ctc tac cac gcc ttc tca      576
 Gly Asp Ala Leu Val Asp Phe Ser Leu Lys Leu Tyr His Ala Phe Ser
             180                 185                 190

 gca atg aag aag gtg gag acc aac atg gcc ttt tcc cca ttc agc atc      624
 Ala Met Lys Lys Val Glu Thr Asn Met Ala Phe Ser Pro Phe Ser Ile
         195                 200                 205

 gcc agc ctc ctt acc cag gtc ctg ctc ggg gct ggg gag aac acc aaa      672
 Ala Ser Leu Leu Thr Gln Val Leu Leu Gly Ala Gly Glu Asn Thr Lys
     210                 215                 220

 aca aac ctg gag agc atc ctc tct tac ccc aag gac ttc acc tgt gtc      720
 Thr Asn Leu Glu Ser Ile Leu Ser Tyr Pro Lys Asp Phe Thr Cys Val
 225                 230                 235                 240

 cac cag gcc ctg aag ggc ttc acg acc aaa ggt gtc acc tca gtc tct      768
 His Gln Ala Leu Lys Gly Phe Thr Thr Lys Gly Val Thr Ser Val Ser
                 245                 250                 255

 cag atc ttc cac agc cca gac ctg gcc ata agg gac acc ttt gtg aat      816
 Gln Ile Phe His Ser Pro Asp Leu Ala Ile Arg Asp Thr Phe Val Asn
             260                 265                 270

 gcc tct cgg acc ctg tac agc agc agc ccc aga gtc cta agc aac aac      864
 Ala Ser Arg Thr Leu Tyr Ser Ser Ser Pro Arg Val Leu Ser Asn Asn
         275                 280                 285

 agt gac gcc aac ttg gag ctc atc aac acc tgg gtg gcc aag aac acc      912
 Ser Asp Ala Asn Leu Glu Leu Ile Asn Thr Trp Val Ala Lys Asn Thr
     290                 295                 300

 aac aac aag atc agc cgg ctg cta gac agt ctg ccc tcc gat acc cgc      960
 Asn Asn Lys Ile Ser Arg Leu Leu Asp Ser Leu Pro Ser Asp Thr Arg
 305                 310                 315                 320

 ctt gtc ctc ctc aat gct atc tac ctg agt gcc aag tgg aag aca aca     1008
 Leu Val Leu Leu Asn Ala Ile Tyr Leu Ser Ala Lys Trp Lys Thr Thr
                 325                 330                 335

 ttt gat ccc aag aaa acc aga atg gaa ccc ttt cac ttc aaa aac tca     1056
 Phe Asp Pro Lys Lys Thr Arg Met Glu Pro Phe His Phe Lys Asn Ser
             340                 345                 350

 gtt ata aaa gtg ccc atg atg aat agc aag aag tac cct gtg gcc cat     1104
 Val Ile Lys Val Pro Met Met Asn Ser Lys Lys Tyr Pro Val Ala His
         355                 360                 365

 ttc att gac caa act ttg aaa gcc aag gtg ggg cag ctg cag ctc tcc     1152
 Phe Ile Asp Gln Thr Leu Lys Ala Lys Val Gly Gln Leu Gln Leu Ser
     370                 375                 380

 cac aat ctg agt ttg gtg atc ctg gta ccc cag aac ctg aaa cat cgt     1200
 His Asn Leu Ser Leu Val Ile Leu Val Pro Gln Asn Leu Lys His Arg
 385                 390                 395                 400

 ctt gaa gac atg gaa cag gct ctc agc cct tct gtt ttc aag gcc atc     1248
 Leu Glu Asp Met Glu Gln Ala Leu Ser Pro Ser Val Phe Lys Ala Ile
                 405                 410                 415

 atg gag aaa ctg gag atg tcc aag ttc cag ccc act ctc cta aca cta     1296
 Met Glu Lys Leu Glu Met Ser Lys Phe Gln Pro Thr Leu Leu Thr Leu
             420                 425                 430

 ccc cgc atc aaa gtg acg acc agc cag gat atg ctc tca atc atg gag     1344
 Pro Arg Ile Lys Val Thr Thr Ser Gln Asp Met Leu Ser Ile Met Glu
         435                 440                 445

 aaa ttg gaa ttc ttc gat ttt tct tat gac ctt aac ctg tgt ggg ctg     1392
 Lys Leu Glu Phe Phe Asp Phe Ser Tyr Asp Leu Asn Leu Cys Gly Leu
     450                 455                 460

 aca gag gac cca gat ctt cag gtt tct gcg atg cag cac cag aca gtg     1440
 Thr Glu Asp Pro Asp Leu Gln Val Ser Ala Met Gln His Gln Thr Val
 465                 470                 475                 480

 ctg gaa ctg aca gag act ggg gtg gag gcg gct gca gcc tcc gcc atc     1488
 Leu Glu Leu Thr Glu Thr Gly Val Glu Ala Ala Ala Ala Ser Ala Ile
                 485                 490                 495

 tct gtg gcc cgc acc ctg ctg gtc ttt gaa gtg cag cag ccc ttc ctc     1536
 Ser Val Ala Arg Thr Leu Leu Val Phe Glu Val Gln Gln Pro Phe Leu
             500                 505                 510

 ttc gtg ctc tgg gac cag cag cac aag ttc cct gtc ttc atg ggg cga     1584
 Phe Val Leu Trp Asp Gln Gln His Lys Phe Pro Val Phe Met Gly Arg
         515                 520                 525

 gta tat gac ccc agg gcc tga                                         1605
 Val Tyr Asp Pro Arg Ala 
     530





      <210> 34
      <211> 1005
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (115)..(825)

      <400> 34
 aagtcaaagg ttccggttga aatcaagttg ggaaacacac ccttgttcat tctccttgag     60

 aagcagctat tatcaacaga acattgacag aacctgtgtt tggggaaagg actg  atg     117
                                                              Met
                                                                1

 gct ttg agt cta ggt tgg aaa gca cac agg aac cac tgt ggt ctc ctc      165
 Ala Leu Ser Leu Gly Trp Lys Ala His Arg Asn His Cys Gly Leu Leu
               5                  10                  15

 ttg cag gct ctg cga agc agt ggt ctt ctc ttg ttt ccc tgt ggc cag      213
 Leu Gln Ala Leu Arg Ser Ser Gly Leu Leu Leu Phe Pro Cys Gly Gln
          20                  25                  30

 tgt ccc tgg aga gga gct gga agc ttt ttg gac cct gag ata aag gct      261
 Cys Pro Trp Arg Gly Ala Gly Ser Phe Leu Asp Pro Glu Ile Lys Ala
      35                  40                  45

 ttc ctg gag gag aac act gaa gtc acc agc agt ggt agc ctc acc cct      309
 Phe Leu Glu Glu Asn Thr Glu Val Thr Ser Ser Gly Ser Leu Thr Pro
  50                  55                  60                  65

 gaa atc cag ttg cgg ctt ttg acc ccc aga tgc aaa ttc tgg tat ctt      357
 Glu Ile Gln Leu Arg Leu Leu Thr Pro Arg Cys Lys Phe Trp Tyr Leu
                  70                  75                  80

 ttg gat aat cct gat gtt gtc aga gga aaa tct gta tta gat ctt ggg      405
 Leu Asp Asn Pro Asp Val Val Arg Gly Lys Ser Val Leu Asp Leu Gly
              85                  90                  95

 agt gga tgt gga gct aca gct att gct gct aag atg agt ggg gca tca      453
 Ser Gly Cys Gly Ala Thr Ala Ile Ala Ala Lys Met Ser Gly Ala Ser
         100                 105                 110

 agg atc ttg gcc aat gac ata gac cct att gca gga atg gct att aca      501
 Arg Ile Leu Ala Asn Asp Ile Asp Pro Ile Ala Gly Met Ala Ile Thr
     115                 120                 125

 cta aat tgt gaa ttg aac aga ctg aat cct ttt cct att tta atc caa      549
 Leu Asn Cys Glu Leu Asn Arg Leu Asn Pro Phe Pro Ile Leu Ile Gln
 130                 135                 140                 145

 aac att ttg aat ttg gaa caa gat aag tgg gac ctt gtt gtt ctt ggc      597
 Asn Ile Leu Asn Leu Glu Gln Asp Lys Trp Asp Leu Val Val Leu Gly
                 150                 155                 160

 gat atg ttt tat gat gaa gac ctt gca gat agt ctt cat cag tgg ctg      645
 Asp Met Phe Tyr Asp Glu Asp Leu Ala Asp Ser Leu His Gln Trp Leu
             165                 170                 175

 aag aag tgc ttc tgg acc tat aga act cga gta ctg att ggt gac cct      693
 Lys Lys Cys Phe Trp Thr Tyr Arg Thr Arg Val Leu Ile Gly Asp Pro
         180                 185                 190

 ggg cgg ccc cag ttc agt gga cac agc att cag cat cac ctg cac aaa      741
 Gly Arg Pro Gln Phe Ser Gly His Ser Ile Gln His His Leu His Lys
     195                 200                 205

 gtg gta gaa tat tca ctt ttg gag tct act agg cag gaa aac agt gga      789
 Val Val Glu Tyr Ser Leu Leu Glu Ser Thr Arg Gln Glu Asn Ser Gly
 210                 215                 220                 225

 ctg aca aca agc aca gtg tgg ggt ttt cag cct tga gttg tcaaagtgct      839
 Leu Thr Thr Ser Thr Val Trp Gly Phe Gln Pro 
                 230                 235

 tccaagtatg aatatagtaa tgtttggatc tgactctaaa agttttctct ataggagata    899

 ctctccagtt taatgaatgt aattcttgtt aaatggaaaa tcttgttttt aaaatatgaa    959

 ggtttagagt tttgtttact tttgtcatgt aactgcgtct ggattt                  1005




      <210> 35
      <211> 1186
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (594)..(1004)

      <400> 35
 gttttctgtc tcgtgttctc gcttgttttc ttgtctttcg tttttgttcg tctttctgtg     60

 ttctgcgtgt ctagttctct gtggtgtttt gtgtttcgct ctcttctgtc tctcctggtt    120

 ctctgtgatc ggtggtctct gcttgttttc ctcagcgcgg ctgttccttc cctctgttcg    180

 cttcccgttg ctcctttgtg gtacacttgt tcagttgtta ccagactctg gcttgtccgt    240

 tcgacgtctc gtgatttctc actccggtct ctgggtcttg tctctggctt ggtctttgtt    300

 acattatgcc aatgcctagc catcgctggc tattccctcg tctgtgccct tgcccttcct    360

 gactctctgt tcttgggtac gttgtgttgt ccagcgagtc tgactctgtt gatctacctg    420

 tgcttgggcc cctcccctca gagcccatgg taacgaaccc ctagaaagga gagaacgggc    480

 gtcaggggtg cacagtccac agctgaagag caaggtttcg tggcagcacg gcccggcccc    540

 tcaccctctg tccccacgag gggacccatg ggggctgtct ttgcagggca cag   atg     596
                                                              Met
                                                                1

 acc aaa gtc cct tcc tgc ttc ctg tta cct gtc ttg ctc ctg ggg aga      644
 Thr Lys Val Pro Ser Cys Phe Leu Leu Pro Val Leu Leu Leu Gly Arg
               5                  10                  15

 aag agg ggc ctg atg aga ctc cac tca ggt gca cac atc acc ggt gca      692
 Lys Arg Gly Leu Met Arg Leu His Ser Gly Ala His Ile Thr Gly Ala
          20                  25                  30

 tct gca ggc acc ggg ctg gct gct tgc agc cag gag aag gtc agc gag      740
 Ser Ala Gly Thr Gly Leu Ala Ala Cys Ser Gln Glu Lys Val Ser Glu
      35                  40                  45

 aag gag tgt atg agt gtg agt gtg tgt gca tgg aag ttg ggg cac tgg      788
 Lys Glu Cys Met Ser Val Ser Val Cys Ala Trp Lys Leu Gly His Trp
  50                  55                  60                  65

 gcg tct gac tcc ctc ccc acc caa gag agg aag gac ccc tca cca ccc      836
 Ala Ser Asp Ser Leu Pro Thr Gln Glu Arg Lys Asp Pro Ser Pro Pro
                  70                  75                  80

 cca ctg gtg aga cag ttt act ttg cca act tgc cat gtt ttt gcc aaa      884
 Pro Leu Val Arg Gln Phe Thr Leu Pro Thr Cys His Val Phe Ala Lys
              85                  90                  95

 acc aag att ttg aag gaa atg agt ggc cag cgc cag ggc cca ggc cat      932
 Thr Lys Ile Leu Lys Glu Met Ser Gly Gln Arg Gln Gly Pro Gly His
         100                 105                 110

 gtg gcc tgc cca gcc tca atg tca ctt ggt ggc ggg gtg ggg tgg ggg      980
 Val Ala Cys Pro Ala Ser Met Ser Leu Gly Gly Gly Val Gly Trp Gly
     115                 120                 125

 tgg gca gca gca tcc cag cct tga gatgcttcac tttccttctc tgtaaccaga    1034
 Trp Ala Ala Ala Ser Gln Pro 
 130                 135

 ctttgaaaaa ttgttcgttt catcaggctc tgttcctcaa tggccttttg ctacgtgcct   1094

 cccgagaaat ttgtcttttt gtataaatga caaagtgttg aaaatgtatt tcctgaaata   1154

 aatgtttcaa atgcaaaaaa aaaaaaaaaa ag                                 1186




      <210> 36
      <211> 2601
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (287)..(2263)

      <400> 36
 ttcgtaacgc gcggagccgt ctgggagagg cctctggagc aggaggccca gtggctcttc     60

 tgacccaagg ccccgccgtc caggtagggg gctgtggcct ctagggatca gggactactt    120

 acctgcgaat cccggttgcc cgcccgccag cacgtccgtt ccctaagcag accgcctggc    180

 ctcctgcctg acccgtcttc tcaccgttgc ccggagtctg acctgcccac gctcagtcca    240

 ctaacgaagc tatccctgct cctgccccac agcttctaag tgccag   atg atg gag     295
                                                      Met Met Glu
                                                        1

 gag cgt gcc aac ctg atg cac atg atg aaa ctc agc atc aag gtg ttg      343
 Glu Arg Ala Asn Leu Met His Met Met Lys Leu Ser Ile Lys Val Leu
       5                  10                  15

 ctc cag tcg gct ctg agc ctg ggc cgc agc ctg gat gcg gac cat gcc      391
 Leu Gln Ser Ala Leu Ser Leu Gly Arg Ser Leu Asp Ala Asp His Ala
  20                  25                  30                  35

 ccc ttg cag cag ttc ttt gta gtg atg gag cac tgc ctc aaa cat ggg      439
 Pro Leu Gln Gln Phe Phe Val Val Met Glu His Cys Leu Lys His Gly
                  40                  45                  50

 ctg aaa gtt aag aag agt ttt att ggc caa aat aaa tca ttc ttt ggt      487
 Leu Lys Val Lys Lys Ser Phe Ile Gly Gln Asn Lys Ser Phe Phe Gly
              55                  60                  65

 cct ttg gag ctg gtg gag aaa ctt tgt cca gaa gca tca gat ata gcg      535
 Pro Leu Glu Leu Val Glu Lys Leu Cys Pro Glu Ala Ser Asp Ile Ala
          70                  75                  80

 act agt gtc aga aat ctt cca gaa tta aag aca gct gtg gga aga ggc      583
 Thr Ser Val Arg Asn Leu Pro Glu Leu Lys Thr Ala Val Gly Arg Gly
      85                  90                  95

 cga gcg tgg ctt tat ctt gca ctc atg caa aag aaa ctg gca gat tat      631
 Arg Ala Trp Leu Tyr Leu Ala Leu Met Gln Lys Lys Leu Ala Asp Tyr
 100                 105                 110                 115

 ctg aaa gtg ctt ata gac aat aaa cat ctc tta agc gag ttc tat gag      679
 Leu Lys Val Leu Ile Asp Asn Lys His Leu Leu Ser Glu Phe Tyr Glu
                 120                 125                 130

 cct gag gct tta atg atg gag gaa gaa ggg atg gtg att gtt ggt ctg      727
 Pro Glu Ala Leu Met Met Glu Glu Glu Gly Met Val Ile Val Gly Leu
             135                 140                 145

 ctg gtg gga ctc aat gtt ctc gat gcc aat ctc tgc ttg aaa gga gaa      775
 Leu Val Gly Leu Asn Val Leu Asp Ala Asn Leu Cys Leu Lys Gly Glu
         150                 155                 160

 gac ttg gat tct cag gtt gga gta ata gat ttt tcc ctc tac ctt aag      823
 Asp Leu Asp Ser Gln Val Gly Val Ile Asp Phe Ser Leu Tyr Leu Lys
     165                 170                 175

 gat gtg cag gat ctt gat ggt ggc aag gag cat gaa aga att act gat      871
 Asp Val Gln Asp Leu Asp Gly Gly Lys Glu His Glu Arg Ile Thr Asp
 180                 185                 190                 195

 gtc ctt gat caa aaa aat tat gtg gaa gaa ctt aac cgg cac ttg agc      919
 Val Leu Asp Gln Lys Asn Tyr Val Glu Glu Leu Asn Arg His Leu Ser
                 200                 205                 210

 tgc aca gtt ggg gat ctt caa acc aag ata gat ggc ttg gaa aag act      967
 Cys Thr Val Gly Asp Leu Gln Thr Lys Ile Asp Gly Leu Glu Lys Thr
             215                 220                 225

 aac tca aag ctt caa gaa gag ctt tca gct gca aca gac cga att tgc     1015
 Asn Ser Lys Leu Gln Glu Glu Leu Ser Ala Ala Thr Asp Arg Ile Cys
         230                 235                 240

 tca ctt caa gaa gaa cag cag cag tta aga gaa caa aat gaa tta att     1063
 Ser Leu Gln Glu Glu Gln Gln Gln Leu Arg Glu Gln Asn Glu Leu Ile
     245                 250                 255

 cga gaa aga agt gaa aag agt gta gag ata aca aaa cag gat acc aaa     1111
 Arg Glu Arg Ser Glu Lys Ser Val Glu Ile Thr Lys Gln Asp Thr Lys
 260                 265                 270                 275

 gtt gag ctg gag act tac aag caa act cgg caa ggt ctg gat gaa atg     1159
 Val Glu Leu Glu Thr Tyr Lys Gln Thr Arg Gln Gly Leu Asp Glu Met
                 280                 285                 290

 tac agt gat gtg tgg aag cag cta aaa gag gag aag aaa gtc cgg ttg     1207
 Tyr Ser Asp Val Trp Lys Gln Leu Lys Glu Glu Lys Lys Val Arg Leu
             295                 300                 305

 gaa ctg gaa aaa gaa ctg gag tta caa att gga atg aaa acc gaa atg     1255
 Glu Leu Glu Lys Glu Leu Glu Leu Gln Ile Gly Met Lys Thr Glu Met
         310                 315                 320

 gaa att gca atg aag tta ctg gaa aag gac acc cac gag aag cag gac     1303
 Glu Ile Ala Met Lys Leu Leu Glu Lys Asp Thr His Glu Lys Gln Asp
     325                 330                 335

 aca cta gtt gcc ctc cgc cag cag ctg gaa gaa gtc aaa gcg att aat     1351
 Thr Leu Val Ala Leu Arg Gln Gln Leu Glu Glu Val Lys Ala Ile Asn
 340                 345                 350                 355

 tta cag atg ttt cac aaa gct cag aat gca gag agc agt ttg cag cag     1399
 Leu Gln Met Phe His Lys Ala Gln Asn Ala Glu Ser Ser Leu Gln Gln
                 360                 365                 370

 aag aat gaa gcc atc aca tcc ttt gaa gga aaa acc aac caa gtt atg     1447
 Lys Asn Glu Ala Ile Thr Ser Phe Glu Gly Lys Thr Asn Gln Val Met
             375                 380                 385

 tcc agc atg aaa caa atg gaa gaa agg ttg cag cac tcg gag cgg gcg     1495
 Ser Ser Met Lys Gln Met Glu Glu Arg Leu Gln His Ser Glu Arg Ala
         390                 395                 400

 agg cag ggg gct gag gag cgg agc cac aag ctg cag cag gag ctg ggc     1543
 Arg Gln Gly Ala Glu Glu Arg Ser His Lys Leu Gln Gln Glu Leu Gly
     405                 410                 415

 ggg agg atc ggc gcc ctg cag ctg cag ctc tcc cag ctg cac gag caa     1591
 Gly Arg Ile Gly Ala Leu Gln Leu Gln Leu Ser Gln Leu His Glu Gln
 420                 425                 430                 435

 tgc tca agc ctg gag aaa gaa ttg aaa tca gaa aaa gag caa aga cag     1639
 Cys Ser Ser Leu Glu Lys Glu Leu Lys Ser Glu Lys Glu Gln Arg Gln
                 440                 445                 450

 gct ctt cag cgc gaa tta cag cac gag aaa gac act tcc tct cta ctc     1687
 Ala Leu Gln Arg Glu Leu Gln His Glu Lys Asp Thr Ser Ser Leu Leu
             455                 460                 465

 agg atg gag ctg caa caa gtg gaa gga ctg aaa aag gag ttg cgg gag     1735
 Arg Met Glu Leu Gln Gln Val Glu Gly Leu Lys Lys Glu Leu Arg Glu
         470                 475                 480

 ctt cag gac gag aag gca gag ctg cag aag atc tgc gag gag cag gaa     1783
 Leu Gln Asp Glu Lys Ala Glu Leu Gln Lys Ile Cys Glu Glu Gln Glu
     485                 490                 495

 caa gcc ctc cag gaa atg ggc ctg cac ctc agc cag tcc aag ctg aag     1831
 Gln Ala Leu Gln Glu Met Gly Leu His Leu Ser Gln Ser Lys Leu Lys
 500                 505                 510                 515

 atg gaa gat ata aaa gaa gtg aac cag gca ctg aag ggc cac gcc tgg     1879
 Met Glu Asp Ile Lys Glu Val Asn Gln Ala Leu Lys Gly His Ala Trp
                 520                 525                 530

 ctg aaa gat gac gaa gcg aca cac tgt agg cag tgt gag aag gag ttc     1927
 Leu Lys Asp Asp Glu Ala Thr His Cys Arg Gln Cys Glu Lys Glu Phe
             535                 540                 545

 tcc att tcc cgg aga aag cac cac tgc cgg aac tgt ggc cac atc ttc     1975
 Ser Ile Ser Arg Arg Lys His His Cys Arg Asn Cys Gly His Ile Phe
         550                 555                 560

 tgc aac acc tgc tcc agc aac gag cta ccc tgc cct cct acc cca agc     2023
 Cys Asn Thr Cys Ser Ser Asn Glu Leu Pro Cys Pro Pro Thr Pro Ser
     565                 570                 575

 cgg tgc gag tgt gcg aca gct gcc aca ccc tgc tcc tgc agc gct gct     2071
 Arg Cys Glu Cys Ala Thr Ala Ala Thr Pro Cys Ser Cys Ser Ala Ala
 580                 585                 590                 595

 cct cca cgg cct cct gaa cgt ccg tcc tca gga gca cag cct cac gga     2119
 Pro Pro Arg Pro Pro Glu Arg Pro Ser Ser Gly Ala Gln Pro His Gly
                 600                 605                 610

 cag tgc caa acc ctg tgg gtc tcc agg ggc ttg gga aat gtg ttc ttt     2167
 Gln Cys Gln Thr Leu Trp Val Ser Arg Gly Leu Gly Asn Val Phe Phe
             615                 620                 625

 ccc aag agt atc aaa gga aag aat caa att tct tgc ccg gtc act ggc     2215
 Pro Lys Ser Ile Lys Gly Lys Asn Gln Ile Ser Cys Pro Val Thr Gly
         630                 635                 640

 act cca gaa gac agc gtg ccg gaa ccg gca gct ctc acc ttt ctg tga     2263
 Thr Pro Glu Asp Ser Val Pro Glu Pro Ala Ala Leu Thr Phe Leu 
     645                 650                 655

 cttgttcgga attaactcct ctggatggaa acttccatct tacttggtta catcacggct   2323

 ctggttcaga tacaacttca tgattttgct actatcattt ttcacttttc aaagaattta   2383

 acctatttta cagcagttca gttctgctag tgagtagttt tcctctccta ccttccttct   2443

 aaaaacctga ttcatgcacg gcgtttgaca cacatggagt ctgccagtgt gccttctctg   2503

 cttcagacaa gagatctgcc atttcatgcc cttgtgacta cctatcattg gccctgcaat   2563

 aaaatcattt atttttcaaa aaaaaaaaaa aaaaaacc                           2601




      <210> 37
      <211> 939
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (1)..(939)

      <400> 37
  atg ggg ctg cgg gga gtg ttg cat cta ctt cct act aca gat gct gtg      48
  Met Gly Leu Arg Gly Val Leu His Leu Leu Pro Thr Thr Asp Ala Val
    1               5                  10                  15

 ccc tgt cct cgg atc tcc atg att ccc acc cac tgg ttt atc ctt ctg       96
 Pro Cys Pro Arg Ile Ser Met Ile Pro Thr His Trp Phe Ile Leu Leu
              20                  25                  30

 ttt gta cca gtc ctc ttt gga ctt ccc acc tgt ttg cat cac ctc ccc      144
 Phe Val Pro Val Leu Phe Gly Leu Pro Thr Cys Leu His His Leu Pro
          35                  40                  45

 aac ttc ccg att cga ccc cca agt cct ata tct gta cga tac ctg tgc      192
 Asn Phe Pro Ile Arg Pro Pro Ser Pro Ile Ser Val Arg Tyr Leu Cys
      50                  55                  60

 atg cct tgt atg gaa gtc ccc atg gct cac ctg atg gct gct agg gaa      240
 Met Pro Cys Met Glu Val Pro Met Ala His Leu Met Ala Ala Arg Glu
  65                  70                  75                  80

 cag agt gga aac cct ccg cag cag ctg gtc aca gaa gca gaa ttg atg      288
 Gln Ser Gly Asn Pro Pro Gln Gln Leu Val Thr Glu Ala Glu Leu Met
                  85                  90                  95

 tcc tcg tcg ggt tct cca ttc agg gac caa atg ctc agc aaa tgc cta      336
 Ser Ser Ser Gly Ser Pro Phe Arg Asp Gln Met Leu Ser Lys Cys Leu
             100                 105                 110

 gag agc gaa tgg cag gca ttt cgt aga ata gaa aga gta aga cag ttt      384
 Glu Ser Glu Trp Gln Ala Phe Arg Arg Ile Glu Arg Val Arg Gln Phe
         115                 120                 125

 gga gct gaa att cac act cta tta tta tac tgt gaa atc cta gtg cgc      432
 Gly Ala Glu Ile His Thr Leu Leu Leu Tyr Cys Glu Ile Leu Val Arg
     130                 135                 140

 tcc ttc tgt gtc agc ctt tgt gtc aga tac cta cat att tat tat ctt      480
 Ser Phe Cys Val Ser Leu Cys Val Arg Tyr Leu His Ile Tyr Tyr Leu
 145                 150                 155                 160

 act cac tcc tca cat caa ctc ggt gat ctg aag att gtc tct att ttc      528
 Thr His Ser Ser His Gln Leu Gly Asp Leu Lys Ile Val Ser Ile Phe
                 165                 170                 175

 cct ctg agg aaa cag aag ttc aga gaa tgt gag aaa ccc atg gaa gga      576
 Pro Leu Arg Lys Gln Lys Phe Arg Glu Cys Glu Lys Pro Met Glu Gly
             180                 185                 190

 aag cag tgt tcc tct caa gat att atg ggg tcc cag gga gat gca gtg      624
 Lys Gln Cys Ser Ser Gln Asp Ile Met Gly Ser Gln Gly Asp Ala Val
         195                 200                 205

 tcc agg gaa gca gag gca gca gca cag ctg cag gaa gaa gtc agg gtg      672
 Ser Arg Glu Ala Glu Ala Ala Ala Gln Leu Gln Glu Glu Val Arg Val
     210                 215                 220

 gaa tcc aca cag agc gca ttc cca ggc tgg gag cta cca gag tat ttg      720
 Glu Ser Thr Gln Ser Ala Phe Pro Gly Trp Glu Leu Pro Glu Tyr Leu
 225                 230                 235                 240

 acc ttg ggc aca gct ggg gtg gcc ccg atg gcg ctg ctg tct gct gat      768
 Thr Leu Gly Thr Ala Gly Val Ala Pro Met Ala Leu Leu Ser Ala Asp
                 245                 250                 255

 ggt ctc cac agc ttc ccc agc gag gcc ttc ctg gaa gga gtg ctg agc      816
 Gly Leu His Ser Phe Pro Ser Glu Ala Phe Leu Glu Gly Val Leu Ser
             260                 265                 270

 agc aaa gct ctg tgg tca cca ctc agg aca aag ggg aac cag ctg aac      864
 Ser Lys Ala Leu Trp Ser Pro Leu Arg Thr Lys Gly Asn Gln Leu Asn
         275                 280                 285

 aga gcc ttt cat gtg aca aca aaa aac gac ctg gct caa aca tca cga      912
 Arg Ala Phe His Val Thr Thr Lys Asn Asp Leu Ala Gln Thr Ser Arg
     290                 295                 300

 cag gca tct gtg gag cct ggg aaa tga                                  939
 Gln Ala Ser Val Glu Pro Gly Lys 
 305                 310





      <210> 38
      <211> 747
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (1)..(468)

      <400> 38
  atg aag gga ctc aga agt ctg gca gca aca acc ttg gct ctt ttc ctg      48
  Met Lys Gly Leu Arg Ser Leu Ala Ala Thr Thr Leu Ala Leu Phe Leu
    1               5                  10                  15

 gtg ttt gtt ttc ctg gga aac tcc agc tgc gct ccg cag aga ctg ttg       96
 Val Phe Val Phe Leu Gly Asn Ser Ser Cys Ala Pro Gln Arg Leu Leu
              20                  25                  30

 gag aga agg aac tgg act cct caa gct atg ctc tac ctg aaa ggg gca      144
 Glu Arg Arg Asn Trp Thr Pro Gln Ala Met Leu Tyr Leu Lys Gly Ala
          35                  40                  45

 cag ggt cgc cgc ttc atc tcc gac cag agc cgg aga aag gac ctc tcc      192
 Gln Gly Arg Arg Phe Ile Ser Asp Gln Ser Arg Arg Lys Asp Leu Ser
      50                  55                  60

 gac cgg cca ctg ccg gaa aga cga agc cca aat ccc caa cta cta act      240
 Asp Arg Pro Leu Pro Glu Arg Arg Ser Pro Asn Pro Gln Leu Leu Thr
  65                  70                  75                  80

 att ccg gag gca gca acc atc tta ctg gcg tcc ctt cag ata gtt agt      288
 Ile Pro Glu Ala Ala Thr Ile Leu Leu Ala Ser Leu Gln Ile Val Ser
                  85                  90                  95

 agt tgg aga aag gac ctc tcc gac cgg cca ctg ccg gaa aga cga agc      336
 Ser Trp Arg Lys Asp Leu Ser Asp Arg Pro Leu Pro Glu Arg Arg Ser
             100                 105                 110

 cca aat ccc caa cta cta act att ccg gag gca gca acc atc tta ctg      384
 Pro Asn Pro Gln Leu Leu Thr Ile Pro Glu Ala Ala Thr Ile Leu Leu
         115                 120                 125

 gcg tcc ctt cag aaa tca cca gaa gat gaa gaa aaa aac ttt gat caa      432
 Ala Ser Leu Gln Lys Ser Pro Glu Asp Glu Glu Lys Asn Phe Asp Gln
     130                 135                 140

 acc aga ttc ctg gaa gac agt ctg ctt aac tgg tga aaat atactggatt      482
 Thr Arg Phe Leu Glu Asp Ser Leu Leu Asn Trp 
 145                 150                 155

 atgtttaatt atggttctat tctctttgaa aacatgaacc atgtgaataa aacctttgga    542

 cccttttatt ccatttgtaa tcttaagaac acacacagat agttttattc tttcagaaac    602

 aaaatatata taggatgctt agctgagaac atcatcttct ttcattgctt caggtcctgt    662

 ttagatgacc aaaaatgttt tcagatcacc ttgtgtctta ctcttgagtt tcttagaata    722

 tttataatta taaggctgaa gacta                                          747




      <210> 39
      <211> 819
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (20)..(745)

      <400> 39
 ctatcaaagc accttagac atg cac gag gaa gaa ata tac acc tct ctt cag      52
                      Met His Glu Glu Glu Ile Tyr Thr Ser Leu Gln
                        1               5                  10

 tgg gat agc cca gca cca gac act tac cag aaa tgt ctg tct tcc aac      100
 Trp Asp Ser Pro Ala Pro Asp Thr Tyr Gln Lys Cys Leu Ser Ser Asn
              15                  20                  25

 aaa tgt tca gga gca tgc tgt ctt gtg atg gtg att tca tgt gtt ttc      148
 Lys Cys Ser Gly Ala Cys Cys Leu Val Met Val Ile Ser Cys Val Phe
          30                  35                  40

 tgc atg gga tta tta acg gca tcc att ttc ttg ggc gtc aag ttg ttg      196
 Cys Met Gly Leu Leu Thr Ala Ser Ile Phe Leu Gly Val Lys Leu Leu
      45                  50                  55

 cag gtg tcc acc att gcg atg cag cag caa gaa aaa ctc atc caa caa      244
 Gln Val Ser Thr Ile Ala Met Gln Gln Gln Glu Lys Leu Ile Gln Gln
  60                  65                  70                  75

 gag agg gca ctg cta aac ttt aca gaa tgg aag aga agc tgt gcc ctt      292
 Glu Arg Ala Leu Leu Asn Phe Thr Glu Trp Lys Arg Ser Cys Ala Leu
                  80                  85                  90

 cag atg aaa tat tgc caa gcc ttc atg caa aac tca tta agt tca gcc      340
 Gln Met Lys Tyr Cys Gln Ala Phe Met Gln Asn Ser Leu Ser Ser Ala
              95                 100                 105

 cat aac agc agt cct tgt cca aac aat tgg att cag aac aga gaa agt      388
 His Asn Ser Ser Pro Cys Pro Asn Asn Trp Ile Gln Asn Arg Glu Ser
         110                 115                 120

 tgt tac tat gtc tct gaa att tgg agc att tgg cac acc agt caa gag      436
 Cys Tyr Tyr Val Ser Glu Ile Trp Ser Ile Trp His Thr Ser Gln Glu
     125                 130                 135

 aat tgt tta aag gaa ggt tcc acg ctg cta caa ata gag agc aaa gaa      484
 Asn Cys Leu Lys Glu Gly Ser Thr Leu Leu Gln Ile Glu Ser Lys Glu
 140                 145                 150                 155

 gaa atg gat ttt atc act ggc agc ttg agg aag att aaa gga agc tat      532
 Glu Met Asp Phe Ile Thr Gly Ser Leu Arg Lys Ile Lys Gly Ser Tyr
                 160                 165                 170

 gat tac tgg gtg ggg ttg tct cag gat gga cac agc gga cgc tgg ctt      580
 Asp Tyr Trp Val Gly Leu Ser Gln Asp Gly His Ser Gly Arg Trp Leu
             175                 180                 185

 tgg caa gat ggc tcc tct cct tct cct ggc ctg ttg cca gca gag aga      628
 Trp Gln Asp Gly Ser Ser Pro Ser Pro Gly Leu Leu Pro Ala Glu Arg
         190                 195                 200

 tcc cag tca gct aac caa gtc tgt gga tac gtg aaa agc aat tcc ctt      676
 Ser Gln Ser Ala Asn Gln Val Cys Gly Tyr Val Lys Ser Asn Ser Leu
     205                 210                 215

 ctt tcg tct aac tgc agc acg tgg aag tat ttt atc tgt gag aag tat      724
 Leu Ser Ser Asn Cys Ser Thr Trp Lys Tyr Phe Ile Cys Glu Lys Tyr
 220                 225                 230                 235

 gcg ttg aga tcc tct gtc tga aa gaaattgtgt tcaaagtgtt ctattacact      777
 Ala Leu Arg Ser Ser Val 
                 240

 gttatttgga gcatgccatt ggaaaactcc gggaattccg ga                       819




      <210> 40
      <211> 903
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (1)..(846)

      <400> 40
  atg ggc agc ctt ctg gct tcc tca cta agc tgg aca gct ccg ccc tgg      48
  Met Gly Ser Leu Leu Ala Ser Ser Leu Ser Trp Thr Ala Pro Pro Trp
    1               5                  10                  15

 ctc gcc aag gca gct tca gcc aca ggt ctc ggt gcc tgc acc gcc ata       96
 Leu Ala Lys Ala Ala Ser Ala Thr Gly Leu Gly Ala Cys Thr Ala Ile
              20                  25                  30

 gac acc acc agg tac agc aac tgg ggc ggg agc tcc gag gag gtc ccc      144
 Asp Thr Thr Arg Tyr Ser Asn Trp Gly Gly Ser Ser Glu Glu Val Pro
          35                  40                  45

 gga ggg ccc tgg gga cgc tgg gtg cac tgg agc agg aga ccc ctc ttc      192
 Gly Gly Pro Trp Gly Arg Trp Val His Trp Ser Arg Arg Pro Leu Phe
      50                  55                  60

 ttg gcc ctg gct gtc ctg gtc acc acc gtc ctt tgg gct gtg att ctg      240
 Leu Ala Leu Ala Val Leu Val Thr Thr Val Leu Trp Ala Val Ile Leu
  65                  70                  75                  80

 agt atc cta ttg tcc aag gcc tcc acg gag cgc gcg gcg ctg ctt gac      288
 Ser Ile Leu Leu Ser Lys Ala Ser Thr Glu Arg Ala Ala Leu Leu Asp
                  85                  90                  95

 ggc cac gac ctg ctg agg aca aac gcc tcg aag cag acg gcg gcg ctg      336
 Gly His Asp Leu Leu Arg Thr Asn Ala Ser Lys Gln Thr Ala Ala Leu
             100                 105                 110

 ggt gcc ctg aag gag gag gtc gga gac tgc cac agc tgc tgc tcg ggg      384
 Gly Ala Leu Lys Glu Glu Val Gly Asp Cys His Ser Cys Cys Ser Gly
         115                 120                 125

 acg cag gcg ctg ctg cag acc acg cgc gcg gag ctt ggg gag gcg cag      432
 Thr Gln Ala Leu Leu Gln Thr Thr Arg Ala Glu Leu Gly Glu Ala Gln
     130                 135                 140

 gcg aag ctg atg gag cag gag aga gcc ctg cgg gaa ctg cgt gag cgc      480
 Ala Lys Leu Met Glu Gln Glu Arg Ala Leu Arg Glu Leu Arg Glu Arg
 145                 150                 155                 160

 gtg acc cat ggc ttg gct gaa gcc ggc agg gac cgc gag gac gtc agc      528
 Val Thr His Gly Leu Ala Glu Ala Gly Arg Asp Arg Glu Asp Val Ser
                 165                 170                 175

 acc gag ctg tac cgg gcg ctg gag gcc gtg agg ctg cag aac agt gag      576
 Thr Glu Leu Tyr Arg Ala Leu Glu Ala Val Arg Leu Gln Asn Ser Glu
             180                 185                 190

 ggt tcc tgt gag ccg tgc cct acg tcg tgg ctg ccc ttc ggg ggc tcc      624
 Gly Ser Cys Glu Pro Cys Pro Thr Ser Trp Leu Pro Phe Gly Gly Ser
         195                 200                 205

 tgc tac tat ttc tct gtg ccg aag acc acg tgg gca gag gcg cag ggc      672
 Cys Tyr Tyr Phe Ser Val Pro Lys Thr Thr Trp Ala Glu Ala Gln Gly
     210                 215                 220

 cac tgc gcc gat gcc agc gca cat ctg gcg att gta ggg ggc ctg ggg      720
 His Cys Ala Asp Ala Ser Ala His Leu Ala Ile Val Gly Gly Leu Gly
 225                 230                 235                 240

 gag cag gac ttc ctg agt cgt gac act agt gcc cgt gaa tac tgg atc      768
 Glu Gln Asp Phe Leu Ser Arg Asp Thr Ser Ala Arg Glu Tyr Trp Ile
                 245                 250                 255

 ggc cgc agg gcc gtg caa cac ctg cgc aag gtt cag ggc tac tcg tgg      816
 Gly Arg Arg Ala Val Gln His Leu Arg Lys Val Gln Gly Tyr Ser Trp
             260                 265                 270

 gtg gac gga gtc cca ctc agc ttc agg tag g ggaagggctc ctggtgaaac      867
 Val Asp Gly Val Pro Leu Ser Phe Arg 
         275                 280

 ctgggggcca caggttagac tctagaggac atgttt                              903




      <210> 41
      <211> 5362
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (85)..(4710)

      <400> 41
 gcagcctgca ctgccgctgc cgcctcgccc cgccctgccc tggcgttgtc tctggcactg     60

 tggcggactg accacggccc gggc   atg ggc tgc aag gga gac gcg agc ggt     111
                              Met Gly Cys Lys Gly Asp Ala Ser Gly
                                1               5

 gcg tgt gcc gcg gga gtt tgc tat aaa atg gga gtt ctg gtt gta ctc      159
 Ala Cys Ala Ala Gly Val Cys Tyr Lys Met Gly Val Leu Val Val Leu
  10                  15                  20                  25

 act gtt ctg tgg ctg ttc tcc tca gta aag gcc gac tca aaa gcc att      207
 Thr Val Leu Trp Leu Phe Ser Ser Val Lys Ala Asp Ser Lys Ala Ile
                  30                  35                  40

 aca acc tct ctt aca aca aaa tgg ttt tcc act cca ttg ttg tta gaa      255
 Thr Thr Ser Leu Thr Thr Lys Trp Phe Ser Thr Pro Leu Leu Leu Glu
              45                  50                  55

 gcc agt gag ttt tta gca gaa gac agt caa gag aaa ttt tgg aat ttt      303
 Ala Ser Glu Phe Leu Ala Glu Asp Ser Gln Glu Lys Phe Trp Asn Phe
          60                  65                  70

 gta gaa gcc agt caa aat att gga tca tca gat cat gac ggt acc gat      351
 Val Glu Ala Ser Gln Asn Ile Gly Ser Ser Asp His Asp Gly Thr Asp
      75                  80                  85

 tat tcc tac tat cat gca ata ttg gag gct gca ttt cag ttt ctg tca      399
 Tyr Ser Tyr Tyr His Ala Ile Leu Glu Ala Ala Phe Gln Phe Leu Ser
  90                  95                 100                 105

 ccc ctc cag cag aat ttg ttt aaa ttt tgt ctg tcc ctt cgt tct tac      447
 Pro Leu Gln Gln Asn Leu Phe Lys Phe Cys Leu Ser Leu Arg Ser Tyr
                 110                 115                 120

 tca gct aca atc caa gcc ttc cag cag ata gca gct gat gaa cct cca      495
 Ser Ala Thr Ile Gln Ala Phe Gln Gln Ile Ala Ala Asp Glu Pro Pro
             125                 130                 135

 cca gaa gga tgt aat tcg ttt ttt tca gtg cat gga aag aag act tgt      543
 Pro Glu Gly Cys Asn Ser Phe Phe Ser Val His Gly Lys Lys Thr Cys
         140                 145                 150

 gaa tct gat acc ctt gag gct ctt cta ctg aca gcc tct gaa aga ccc      591
 Glu Ser Asp Thr Leu Glu Ala Leu Leu Leu Thr Ala Ser Glu Arg Pro
     155                 160                 165

 aaa cct tta ttg ttc aaa gga gat cac aga tat ccc tcg tct aat cct      639
 Lys Pro Leu Leu Phe Lys Gly Asp His Arg Tyr Pro Ser Ser Asn Pro
 170                 175                 180                 185

 gaa agc cct gtg gtg att ttc tac tct gag att ggc tct gag gaa ttt      687
 Glu Ser Pro Val Val Ile Phe Tyr Ser Glu Ile Gly Ser Glu Glu Phe
                 190                 195                 200

 tcc aat ttt cac cgc cag ctt ata tca aaa agc aat gca ggc aaa atc      735
 Ser Asn Phe His Arg Gln Leu Ile Ser Lys Ser Asn Ala Gly Lys Ile
             205                 210                 215

 aac tat gta ttc aga cat tat ata ttt aat ccc agg aag gag cct gtt      783
 Asn Tyr Val Phe Arg His Tyr Ile Phe Asn Pro Arg Lys Glu Pro Val
         220                 225                 230

 tac ctc tct ggc tat ggc gtg gaa ttg gcc att aag agc act gag tac      831
 Tyr Leu Ser Gly Tyr Gly Val Glu Leu Ala Ile Lys Ser Thr Glu Tyr
     235                 240                 245

 aag gcc aag gat gat act cag gtg aaa gga act gag gta aac acc aca      879
 Lys Ala Lys Asp Asp Thr Gln Val Lys Gly Thr Glu Val Asn Thr Thr
 250                 255                 260                 265

 gtg att ggt gaa aat gat cct att gat gag gtt cag ggg ttc ctc ttt      927
 Val Ile Gly Glu Asn Asp Pro Ile Asp Glu Val Gln Gly Phe Leu Phe
                 270                 275                 280

 gga aaa tta aga gat ctg cac ccc gac ctg gag gga cag ttg aaa gaa      975
 Gly Lys Leu Arg Asp Leu His Pro Asp Leu Glu Gly Gln Leu Lys Glu
             285                 290                 295

 ctc aga aag cat ctt gta gag agc acc aat gaa atg gca cct tta aaa     1023
 Leu Arg Lys His Leu Val Glu Ser Thr Asn Glu Met Ala Pro Leu Lys
         300                 305                 310

 gtt tgg cag ttg caa gat ctc agt ttc cag act gct gct cga atc ttg     1071
 Val Trp Gln Leu Gln Asp Leu Ser Phe Gln Thr Ala Ala Arg Ile Leu
     315                 320                 325

 gct tct cct gtt gag ttg gct ttg gtt gtc atg aag gat ctt agt cag     1119
 Ala Ser Pro Val Glu Leu Ala Leu Val Val Met Lys Asp Leu Ser Gln
 330                 335                 340                 345

 aat ttt cct acc aaa gcc aga gca ata aca aaa aca gct gtg agc tca     1167
 Asn Phe Pro Thr Lys Ala Arg Ala Ile Thr Lys Thr Ala Val Ser Ser
                 350                 355                 360

 gaa ctt aga acc gaa gtg gaa gag aat cac aag tat ttc aag gga act     1215
 Glu Leu Arg Thr Glu Val Glu Glu Asn His Lys Tyr Phe Lys Gly Thr
             365                 370                 375

 tta gga tta caa cct gga gat tca gcc ctc ttc atc aat gga ctt cac     1263
 Leu Gly Leu Gln Pro Gly Asp Ser Ala Leu Phe Ile Asn Gly Leu His
         380                 385                 390

 atg gat tta gac aca cag gat ata ttc agt ctg ttt gat gtg ttg agg     1311
 Met Asp Leu Asp Thr Gln Asp Ile Phe Ser Leu Phe Asp Val Leu Arg
     395                 400                 405

 aat gaa gct cgg gta atg gag ggt ctg cat aga ttg gga ata gaa ggc     1359
 Asn Glu Ala Arg Val Met Glu Gly Leu His Arg Leu Gly Ile Glu Gly
 410                 415                 420                 425

 ctt tct ctg cat aat gtt ttg aag ctg aac atc cag ccc tct gag gca     1407
 Leu Ser Leu His Asn Val Leu Lys Leu Asn Ile Gln Pro Ser Glu Ala
                 430                 435                 440

 gac tat gcc gta gac atc cgg agt cct gct att tca tgg gtc aac aac     1455
 Asp Tyr Ala Val Asp Ile Arg Ser Pro Ala Ile Ser Trp Val Asn Asn
             445                 450                 455

 ctg gag gtt gat agc aga tat aat tcg tgg cct tct agt tta caa gag     1503
 Leu Glu Val Asp Ser Arg Tyr Asn Ser Trp Pro Ser Ser Leu Gln Glu
         460                 465                 470

 ttg ctt cga ccc acc ttt cct ggt gtt att cgg cag atc agg aaa aac     1551
 Leu Leu Arg Pro Thr Phe Pro Gly Val Ile Arg Gln Ile Arg Lys Asn
     475                 480                 485

 tta cat aat atg gtt ttc ata gtt gat cct gca cat gag acc aca gca     1599
 Leu His Asn Met Val Phe Ile Val Asp Pro Ala His Glu Thr Thr Ala
 490                 495                 500                 505

 gag ttg atg aac aca gct gag atg ttc ctt agt aat cat ata cca cta     1647
 Glu Leu Met Asn Thr Ala Glu Met Phe Leu Ser Asn His Ile Pro Leu
                 510                 515                 520

 aga att ggt ttt atc ttt gtg gtt aat gac tct gaa gat gtt gat ggg     1695
 Arg Ile Gly Phe Ile Phe Val Val Asn Asp Ser Glu Asp Val Asp Gly
             525                 530                 535

 atg caa gat gct gga gtg gct gtt ctt aga gca tat aat tat gtt gcc     1743
 Met Gln Asp Ala Gly Val Ala Val Leu Arg Ala Tyr Asn Tyr Val Ala
         540                 545                 550

 caa gaa gtg gat gat tat cat gcc ttc cag act ctg aca cat atc tat     1791
 Gln Glu Val Asp Asp Tyr His Ala Phe Gln Thr Leu Thr His Ile Tyr
     555                 560                 565

 aac aag gtg agg act gga gaa aaa gtg aaa gtt gaa cat gtg gtc agt     1839
 Asn Lys Val Arg Thr Gly Glu Lys Val Lys Val Glu His Val Val Ser
 570                 575                 580                 585

 gtc ctg gag aag aaa tat ccg tat gta gaa gtg aat agc att ttg ggg     1887
 Val Leu Glu Lys Lys Tyr Pro Tyr Val Glu Val Asn Ser Ile Leu Gly
                 590                 595                 600

 att gat tct gct tat gat cgg aat cgg aag gaa gca aga ggc tac tat     1935
 Ile Asp Ser Ala Tyr Asp Arg Asn Arg Lys Glu Ala Arg Gly Tyr Tyr
             605                 610                 615

 gag cag act gga gtt gga cct ctg ccc gtt gtg ctg ttc aat gga atg     1983
 Glu Gln Thr Gly Val Gly Pro Leu Pro Val Val Leu Phe Asn Gly Met
         620                 625                 630

 ccc ttt gaa agg gaa cag cta gac cct gat gag tta gaa acc atc aca     2031
 Pro Phe Glu Arg Glu Gln Leu Asp Pro Asp Glu Leu Glu Thr Ile Thr
     635                 640                 645

 atg cat aaa atc ctg gag acc acc acc ttc ttc caa aga gcg gtg tac     2079
 Met His Lys Ile Leu Glu Thr Thr Thr Phe Phe Gln Arg Ala Val Tyr
 650                 655                 660                 665

 ttg ggt gaa ctg ccc cat gat caa gat gcg gta gag tat atc atg aat     2127
 Leu Gly Glu Leu Pro His Asp Gln Asp Ala Val Glu Tyr Ile Met Asn
                 670                 675                 680

 cag cca aat gtt gtt cca cga atc aat tct agg att ttg aca gct gaa     2175
 Gln Pro Asn Val Val Pro Arg Ile Asn Ser Arg Ile Leu Thr Ala Glu
             685                 690                 695

 cga gac tac ctg gat tta aca gcg agt aat aac ttc ttt gtg gat gat     2223
 Arg Asp Tyr Leu Asp Leu Thr Ala Ser Asn Asn Phe Phe Val Asp Asp
         700                 705                 710

 tat gct aga ttt act atc ttg gat tcc caa ggc aag act gct gct gta     2271
 Tyr Ala Arg Phe Thr Ile Leu Asp Ser Gln Gly Lys Thr Ala Ala Val
     715                 720                 725

 gcc aat agt atg aac tat ctg aca aag aaa gat gat tct ttt att agg     2319
 Ala Asn Ser Met Asn Tyr Leu Thr Lys Lys Asp Asp Ser Phe Ile Arg
 730                 735                 740                 745

 cca gta act ttt tgg att gtt ggg gat ttt gat agc cct tct gga cgg     2367
 Pro Val Thr Phe Trp Ile Val Gly Asp Phe Asp Ser Pro Ser Gly Arg
                 750                 755                 760

 cag tta ctg tat gat gcc atc aaa cat cag aaa tcc agt aac aat gtt     2415
 Gln Leu Leu Tyr Asp Ala Ile Lys His Gln Lys Ser Ser Asn Asn Val
             765                 770                 775

 aga ata agc atg atc aat aat cct gcc aaa gag ata agc tat gag aac     2463
 Arg Ile Ser Met Ile Asn Asn Pro Ala Lys Glu Ile Ser Tyr Glu Asn
         780                 785                 790

 act cag atc tcc aga gca atc tgg gca gct ctc caa act cag act tcc     2511
 Thr Gln Ile Ser Arg Ala Ile Trp Ala Ala Leu Gln Thr Gln Thr Ser
     795                 800                 805

 aac gct gct aag aac ttc atc acc aaa atg gcc aag gag ggg gct gca     2559
 Asn Ala Ala Lys Asn Phe Ile Thr Lys Met Ala Lys Glu Gly Ala Ala
 810                 815                 820                 825

 gag gcc ctg gct gca gga gct gac att gcg gag ttc tct gtt ggg gga     2607
 Glu Ala Leu Ala Ala Gly Ala Asp Ile Ala Glu Phe Ser Val Gly Gly
                 830                 835                 840

 atg gat ttc agt ctt ttt aaa gag gtc ttt gag tct tcc aaa atg gat     2655
 Met Asp Phe Ser Leu Phe Lys Glu Val Phe Glu Ser Ser Lys Met Asp
             845                 850                 855

 ttc att ttg tct cat gcc gtg tac tgc agg gat gtt ctg aag ctg aag     2703
 Phe Ile Leu Ser His Ala Val Tyr Cys Arg Asp Val Leu Lys Leu Lys
         860                 865                 870

 aag gga cag agg gca gtg atc agc aat gga agg atc att ggg cca ctg     2751
 Lys Gly Gln Arg Ala Val Ile Ser Asn Gly Arg Ile Ile Gly Pro Leu
     875                 880                 885

 gag gat agt gag ctc ttt aat caa gac gat ttc cac ctc ctc gaa aat     2799
 Glu Asp Ser Glu Leu Phe Asn Gln Asp Asp Phe His Leu Leu Glu Asn
 890                 895                 900                 905

 atc atc tta aaa acc tca gga cag aaa ata aaa tct cat att caa cag     2847
 Ile Ile Leu Lys Thr Ser Gly Gln Lys Ile Lys Ser His Ile Gln Gln
                 910                 915                 920

 ctt cgg gta gaa gaa gat gtg gca agc gac ttg gta atg aag gtg gat     2895
 Leu Arg Val Glu Glu Asp Val Ala Ser Asp Leu Val Met Lys Val Asp
             925                 930                 935

 gct ctt ctg tca gcg caa cca aaa gga gat cca aga atc gag tac cag     2943
 Ala Leu Leu Ser Ala Gln Pro Lys Gly Asp Pro Arg Ile Glu Tyr Gln
         940                 945                 950

 ttt ttt gaa gac aga cac agt gca atc aaa ctg agg ccg aag gaa ggg     2991
 Phe Phe Glu Asp Arg His Ser Ala Ile Lys Leu Arg Pro Lys Glu Gly
     955                 960                 965

 gag aca tac ttt gat gtt gtg gct gtc gtt gac cct gtc acc aga gaa     3039
 Glu Thr Tyr Phe Asp Val Val Ala Val Val Asp Pro Val Thr Arg Glu
 970                 975                 980                 985

 gca cag aga ctt gct cct ttg ctc ttg gtt ttg gct cag ctg ata aac     3087
 Ala Gln Arg Leu Ala Pro Leu Leu Leu Val Leu Ala Gln Leu Ile Asn
                 990                 995                1000

 atg aat ctg aga gta ttt atg aac tgc caa tcc aaa ctt tct gac atg     3135
 Met Asn Leu Arg Val Phe Met Asn Cys Gln Ser Lys Leu Ser Asp Met
            1005                1010                1015

 cct tta aaa agc ttt tac cgt tat gtc tta gaa cca gag att tct ttc     3183
 Pro Leu Lys Ser Phe Tyr Arg Tyr Val Leu Glu Pro Glu Ile Ser Phe
        1020                1025                1030

 act tca gac aat agt ttt gct aag ggt cca atc gca aaa ttt ttg gat     3231
 Thr Ser Asp Asn Ser Phe Ala Lys Gly Pro Ile Ala Lys Phe Leu Asp
    1035                1040                1045

 atg cct cag tct cca ctg ttc act ctg aat ttg aac aca cct gag agc     3279
 Met Pro Gln Ser Pro Leu Phe Thr Leu Asn Leu Asn Thr Pro Glu Ser
1050                1055                1060                1065

 tgg atg gta gaa tct gtc aga aca cca tat gat ctt gat aat att tat     3327
 Trp Met Val Glu Ser Val Arg Thr Pro Tyr Asp Leu Asp Asn Ile Tyr
                1070                1075                1080

 tta gaa gag gtg gac agt gta gtg gct gct gag tat gag ctg gaa tac     3375
 Leu Glu Glu Val Asp Ser Val Val Ala Ala Glu Tyr Glu Leu Glu Tyr
            1085                1090                1095

 ctg tta ctg gaa ggt cat tgc tac gac atc acc aca ggc cag cct cca     3423
 Leu Leu Leu Glu Gly His Cys Tyr Asp Ile Thr Thr Gly Gln Pro Pro
        1100                1105                1110

 cgg gga cta cag ttt acc tta gga act tca gcc aac ccg gtc att gtg     3471
 Arg Gly Leu Gln Phe Thr Leu Gly Thr Ser Ala Asn Pro Val Ile Val
    1115                1120                1125

 gac acc att gtt atg gcc aat ctg ggc tac ttt cag ctg aaa gcc aac     3519
 Asp Thr Ile Val Met Ala Asn Leu Gly Tyr Phe Gln Leu Lys Ala Asn
1130                1135                1140                1145

 cca gga gct tgg atc ctc aga ctt agg aag gga cgc tct gaa gat att     3567
 Pro Gly Ala Trp Ile Leu Arg Leu Arg Lys Gly Arg Ser Glu Asp Ile
                1150                1155                1160

 tat aga att tac agc cac gat ggc acc gat tct ccc cct gat gct gat     3615
 Tyr Arg Ile Tyr Ser His Asp Gly Thr Asp Ser Pro Pro Asp Ala Asp
            1165                1170                1175

 gag gtg gtt atc gtc ctc aac aac ttc aaa agc aaa att att aaa gtg     3663
 Glu Val Val Ile Val Leu Asn Asn Phe Lys Ser Lys Ile Ile Lys Val
        1180                1185                1190

 aag gtt cag aag aag gca gat atg gtg aac gaa gac ttg ctg agt gat     3711
 Lys Val Gln Lys Lys Ala Asp Met Val Asn Glu Asp Leu Leu Ser Asp
    1195                1200                1205

 gga acg agt gag aat gaa tct gga ttt tgg gat tcc ttc aaa tgg ggc     3759
 Gly Thr Ser Glu Asn Glu Ser Gly Phe Trp Asp Ser Phe Lys Trp Gly
1210                1215                1220                1225

 ttt aca gga cag aag act gag gaa gtg aag caa gat aaa gat gac ata     3807
 Phe Thr Gly Gln Lys Thr Glu Glu Val Lys Gln Asp Lys Asp Asp Ile
                1230                1235                1240

 att aat att ttc tcc gtt gca tct ggt cat ctc tac gaa aga ttt ctt     3855
 Ile Asn Ile Phe Ser Val Ala Ser Gly His Leu Tyr Glu Arg Phe Leu
            1245                1250                1255

 cgc ata atg atg cta tcc gtg ctg aag aat acc aag act cct gtg aaa     3903
 Arg Ile Met Met Leu Ser Val Leu Lys Asn Thr Lys Thr Pro Val Lys
        1260                1265                1270

 ttc tgg ttc ttg aag aat tac ttg tcc ccc aca ttt aag gag ttt ata     3951
 Phe Trp Phe Leu Lys Asn Tyr Leu Ser Pro Thr Phe Lys Glu Phe Ile
    1275                1280                1285

 cct tac atg gca aat gaa tac aat ttc cag tat gag ctt gtt cag tac     3999
 Pro Tyr Met Ala Asn Glu Tyr Asn Phe Gln Tyr Glu Leu Val Gln Tyr
1290                1295                1300                1305

 aaa tgg ccc cgg tgg ctt cat caa caa act gaa aaa cag cgt atc atc     4047
 Lys Trp Pro Arg Trp Leu His Gln Gln Thr Glu Lys Gln Arg Ile Ile
                1310                1315                1320

 tgg ggt tac aag atc ctc ttc ctg gat gta ctt ttc cca cta gtt gtt     4095
 Trp Gly Tyr Lys Ile Leu Phe Leu Asp Val Leu Phe Pro Leu Val Val
            1325                1330                1335

 gac aag ttc ctg ttt gtg gat gct gat cag att gta cga aca gat ctg     4143
 Asp Lys Phe Leu Phe Val Asp Ala Asp Gln Ile Val Arg Thr Asp Leu
        1340                1345                1350

 aaa gag tta aga gat ttc aat ttg gat ggt gct cct tat ggt tac act     4191
 Lys Glu Leu Arg Asp Phe Asn Leu Asp Gly Ala Pro Tyr Gly Tyr Thr
    1355                1360                1365

 cct ttc tgt gac agc cga aga gaa atg gac ggc tac agg ttc tgg aag     4239
 Pro Phe Cys Asp Ser Arg Arg Glu Met Asp Gly Tyr Arg Phe Trp Lys
1370                1375                1380                1385

 tca ggg tac tgg gcc agt cat tta gcc ggg cga aag tat cat atc agt     4287
 Ser Gly Tyr Trp Ala Ser His Leu Ala Gly Arg Lys Tyr His Ile Ser
                1390                1395                1400

 gca cta tat gtt gtg gat ctg aag aag ttt agg aaa ata gct gct ggt     4335
 Ala Leu Tyr Val Val Asp Leu Lys Lys Phe Arg Lys Ile Ala Ala Gly
            1405                1410                1415

 gac aga ctc agg gga cag tac caa ggt ctg agt cag gac cct aac agc     4383
 Asp Arg Leu Arg Gly Gln Tyr Gln Gly Leu Ser Gln Asp Pro Asn Ser
        1420                1425                1430

 ctt tca aat ctt gat caa gat ctg ccc aat aac atg att cat cag gtg     4431
 Leu Ser Asn Leu Asp Gln Asp Leu Pro Asn Asn Met Ile His Gln Val
    1435                1440                1445

 cca att aaa tcc ctc cct caa gaa tgg ctt tgg tgt gaa acg tgg tgt     4479
 Pro Ile Lys Ser Leu Pro Gln Glu Trp Leu Trp Cys Glu Thr Trp Cys
1450                1455                1460                1465

 gat gac gcc tct aag aaa agg gca aaa acc att gat ttg tgt aat aat     4527
 Asp Asp Ala Ser Lys Lys Arg Ala Lys Thr Ile Asp Leu Cys Asn Asn
                1470                1475                1480

 ccg atg acc aaa gag ccg aaa ctg gaa gca gct gtg cgg att gtc ccg     4575
 Pro Met Thr Lys Glu Pro Lys Leu Glu Ala Ala Val Arg Ile Val Pro
            1485                1490                1495

 gag tgg cag gac tac gac caa gag atc aaa cag cta cag atc cgc ttt     4623
 Glu Trp Gln Asp Tyr Asp Gln Glu Ile Lys Gln Leu Gln Ile Arg Phe
        1500                1505                1510

 cag aag gag aaa gaa acg gga gca ctg tac aaa gag aag aca aaa gaa     4671
 Gln Lys Glu Lys Glu Thr Gly Ala Leu Tyr Lys Glu Lys Thr Lys Glu
    1515                1520                1525

 cca agc cga gaa ggt cct cag aaa cgt gaa gaa tta tga tctctggaga      4720
 Pro Ser Arg Glu Gly Pro Gln Lys Arg Glu Glu Leu 
1530                1535                1540

 aggacaggaa atcaccccat ttgaaaaaca gtttttataa taaatgctag ttttttctga   4780

 tctgtctata caactgctga taagccggct gggcaggagt gccacacctt ttgattctga   4840

 gcatttgatt ctgacttctg tactctggtg gccactggat ctttgggatt aaagctctgt   4900

 tggatttgta cctcagagga agaccaagtg gctgatcctt tggactctgt aaagagcatt   4960

 cttctagtca gagggtggaa tggcagcagc aactggaaga aaatgagttt tttggtgccc   5020

 acacccaaga gcacacacat gctgcactgt ctcggaaagc agggccagct agagccacca   5080

 tgttcttcct tacctcagtt tacctgcggc ctgcgctgca ctgcagatgc ccaccctgcc   5140

 ctgggtctgg ccggcggaag ctctgtccaa ggtccacaca cctccaggtt tacgccaaca   5200

 tccttgtgcc ctccccacct tctcttccaa cgcattaggt gcattgttta attgaaatcc   5260

 aaccaacaat tgtgtgtcaa ggctggtttg gtgcagtggc tgggcaaatt aattttgggc   5320

 caggatgggg gtgggttgca gtgagggctc agaacaacga ca                      5362




      <210> 42
      <211> 720
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (1)..(720)

      <400> 42
  atg cag cgc ggc gcg ctg tcc ccg gtg ctg atg ctc agc gct gcc ccg      48
  Met Gln Arg Gly Ala Leu Ser Pro Val Leu Met Leu Ser Ala Ala Pro
    1               5                  10                  15

 gag cct ccg ccg cgc ccg cct ccc gcc ctc tcc cca ccg ggc tcg ggc       96
 Glu Pro Pro Pro Arg Pro Pro Pro Ala Leu Ser Pro Pro Gly Ser Gly
              20                  25                  30

 cca ggc tcg ggc tcc cgc cat ggc tcg gct cgt ccc ggt cct acc cca      144
 Pro Gly Ser Gly Ser Arg His Gly Ser Ala Arg Pro Gly Pro Thr Pro
          35                  40                  45

 gag ccg tcg ggg agc ctg ggc gcg gcg ctc gac agc agc ctg cgt gcc      192
 Glu Pro Ser Gly Ser Leu Gly Ala Ala Leu Asp Ser Ser Leu Arg Ala
      50                  55                  60

 gcc gtg gcg ttc aag gca gag ggc cag cgc tgc tat cga gag aag aag      240
 Ala Val Ala Phe Lys Ala Glu Gly Gln Arg Cys Tyr Arg Glu Lys Lys
  65                  70                  75                  80

 ttc cgg gag gcc atc ggc aag tac cac cga gcg ctg ctg cag ctg aag      288
 Phe Arg Glu Ala Ile Gly Lys Tyr His Arg Ala Leu Leu Gln Leu Lys
                  85                  90                  95

 gcg gcg cag ggg gcc cgc cct agc ggc ctg ccc gcc ccc gcc ccc ggg      336
 Ala Ala Gln Gly Ala Arg Pro Ser Gly Leu Pro Ala Pro Ala Pro Gly
             100                 105                 110

 ccc acc agc agc ccc ggg ccg gcg cgc ctc agc gag gag cag cgg cgc      384
 Pro Thr Ser Ser Pro Gly Pro Ala Arg Leu Ser Glu Glu Gln Arg Arg
         115                 120                 125

 ctg gtg gag agc acg gag gtg gag tgt tac gac tcc ctc acg gct tgc      432
 Leu Val Glu Ser Thr Glu Val Glu Cys Tyr Asp Ser Leu Thr Ala Cys
     130                 135                 140

 ctg ctg cag tcg gag ctg gta aac tac gag cgc gtg cgc gag tac tgt      480
 Leu Leu Gln Ser Glu Leu Val Asn Tyr Glu Arg Val Arg Glu Tyr Cys
 145                 150                 155                 160

 ctc aag gta ctg gag aag cag cag ggc aac ttc aag gcc acc tac cgt      528
 Leu Lys Val Leu Glu Lys Gln Gln Gly Asn Phe Lys Ala Thr Tyr Arg
                 165                 170                 175

 gcc ggc att gcc ttc tac cac ctg ggc gac tac gca cgc gcg ctg cgc      576
 Ala Gly Ile Ala Phe Tyr His Leu Gly Asp Tyr Ala Arg Ala Leu Arg
             180                 185                 190

 tac ctg cag gag gcc cgc agc cgg gaa ccc aca gac acc aat gtg ctc      624
 Tyr Leu Gln Glu Ala Arg Ser Arg Glu Pro Thr Asp Thr Asn Val Leu
         195                 200                 205

 cgc tac atc cag ctg act cag ctg aag atg aat cgt tgc agc ctc cag      672
 Arg Tyr Ile Gln Leu Thr Gln Leu Lys Met Asn Arg Cys Ser Leu Gln
     210                 215                 220

 cgg gaa gac agt ggg gct ggg tcc cag act cgg gat gta att ggc tga      720
 Arg Glu Asp Ser Gly Ala Gly Ser Gln Thr Arg Asp Val Ile Gly 
 225                 230                 235





      <210> 43
      <211> 1851
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (263)..(1633)

      <220>
      <221> misc_feature
      <222> (1)...(1851)
      <223> n = a,t,c or g

      <400> 43
 taattcctga gattgctatt gtaaggataa caggagctag acttttgaag ttactcatga     60

 cattagtttg ttgataggaa attctttttt tgaagagcag gaaaatctgt tacatgccat    120

 tatgctctta aagtgtagca ataaggttaa actttttgtg ttctgcagct atggttttgt    180

 ttccttttaa ctatccactg taaaagcctt tttattttaa aatccacact ttttgctgaa    240

 tttagcttgt tagtaattga tt atg caa gaa atg aat gac aaa gca att ttt     292
                          Met Gln Glu Met Asn Asp Lys Ala Ile Phe
                            1               5                  10

 aaa aca ttg ttt ttg ttt ttt cct cag tcc ttg gtt ttg atc agc aaa      340
 Lys Thr Leu Phe Leu Phe Phe Pro Gln Ser Leu Val Leu Ile Ser Lys
                  15                  20                  25

 cta cct tat att cat ttt ttt cac act gtg ctc aaa cag ata gca cca      388
 Leu Pro Tyr Ile His Phe Phe His Thr Val Leu Lys Gln Ile Ala Pro
              30                  35                  40

 gag tat ttt gaa aag aat gaa cct tat ttg gaa gca gct tgt aat gat      436
 Glu Tyr Phe Glu Lys Asn Glu Pro Tyr Leu Glu Ala Ala Cys Asn Asp
          45                  50                  55

 gtt gat cga tgg cct gcc cca gtg cca ggg aaa aca tta cac ctg cca      484
 Val Asp Arg Trp Pro Ala Pro Val Pro Gly Lys Thr Leu His Leu Pro
      60                  65                  70

 atc atg ggg gtg gta atg aag gta cgg att ccc aca tgt cat gac aag      532
 Ile Met Gly Val Val Met Lys Val Arg Ile Pro Thr Cys His Asp Lys
  75                  80                  85                  90

 cct ggg aca act caa ata gtg cag tta act cag cag gtg gac aca aat      580
 Pro Gly Thr Thr Gln Ile Val Gln Leu Thr Gln Gln Val Asp Thr Asn
                  95                 100                 105

 ata tct gtt att tta cct act gtt cat gag ggg gat att ttc agg tgt      628
 Ile Ser Val Ile Leu Pro Thr Val His Glu Gly Asp Ile Phe Arg Cys
             110                 115                 120

 ttc tgc cca gtt ttc ctt cat agt cag atg ctc tgg gag ctg gtg ctg      676
 Phe Cys Pro Val Phe Leu His Ser Gln Met Leu Trp Glu Leu Val Leu
         125                 130                 135

 ttg ggg gag ccc ctt gtg gtt atg gcg cca tca cca tcg gaa tca tca      724
 Leu Gly Glu Pro Leu Val Val Met Ala Pro Ser Pro Ser Glu Ser Ser
     140                 145                 150

 gag act gta ttg gca ctt gtt aac tgt att tct cca tta aag tac ttc      772
 Glu Thr Val Leu Ala Leu Val Asn Cys Ile Ser Pro Leu Lys Tyr Phe
 155                 160                 165                 170

 agt gat ttc cga cct tat ttc act att cat gat agt gaa ttc aaa gaa      820
 Ser Asp Phe Arg Pro Tyr Phe Thr Ile His Asp Ser Glu Phe Lys Glu
                 175                 180                 185

 tat act acc cgt acc caa gct ccg ccc tca gtt ata tta gga gta acc      868
 Tyr Thr Thr Arg Thr Gln Ala Pro Pro Ser Val Ile Leu Gly Val Thr
             190                 195                 200

 aac cct ttt ttt gct aag aca ctc cag cac tgg cca cac att att cga      916
 Asn Pro Phe Phe Ala Lys Thr Leu Gln His Trp Pro His Ile Ile Arg
         205                 210                 215

 ata gga gac ctt aaa cct aca ggt gaa att cct aag cag gtt aaa gtg      964
 Ile Gly Asp Leu Lys Pro Thr Gly Glu Ile Pro Lys Gln Val Lys Val
     220                 225                 230

 aaa aaa ctg aag aat cta aag act ctg gat tcc aaa cct gga gtt tat     1012
 Lys Lys Leu Lys Asn Leu Lys Thr Leu Asp Ser Lys Pro Gly Val Tyr
 235                 240                 245                 250

 act tca tat aag cca tat tta aat aga gat gaa gag atc ata aaa caa     1060
 Thr Ser Tyr Lys Pro Tyr Leu Asn Arg Asp Glu Glu Ile Ile Lys Gln
                 255                 260                 265

 tta cag aag ggt gta caa cag aaa cgt cct tct gag gct caa agt gtt     1108
 Leu Gln Lys Gly Val Gln Gln Lys Arg Pro Ser Glu Ala Gln Ser Val
             270                 275                 280

 att ctt cga cgc tat ttt ttg gaa ctg aca caa agt ttc atc att cca     1156
 Ile Leu Arg Arg Tyr Phe Leu Glu Leu Thr Gln Ser Phe Ile Ile Pro
         285                 290                 295

 tta gaa aga tat gtg gca agc ttg atg cct ttg cag aaa agt att tcc     1204
 Leu Glu Arg Tyr Val Ala Ser Leu Met Pro Leu Gln Lys Ser Ile Ser
     300                 305                 310

 cca tgg aag agt cca cct caa tta aga cag ttt ctt cca gaa gaa ttt     1252
 Pro Trp Lys Ser Pro Pro Gln Leu Arg Gln Phe Leu Pro Glu Glu Phe
 315                 320                 325                 330

 atg aaa aca ctt gag aaa aca gga cct cag cta acc tct aga ata aaa     1300
 Met Lys Thr Leu Glu Lys Thr Gly Pro Gln Leu Thr Ser Arg Ile Lys
                 335                 340                 345

 ggc gat tgg att gga ctt tac cgg cat ttc cta aag tct cca aat ttt     1348
 Gly Asp Trp Ile Gly Leu Tyr Arg His Phe Leu Lys Ser Pro Asn Phe
             350                 355                 360

 gat ggc tgg ttt aag acc cgg agg aag gaa atg acc caa aaa ttg gag     1396
 Asp Gly Trp Phe Lys Thr Arg Arg Lys Glu Met Thr Gln Lys Leu Glu
         365                 370                 375

 gca ctc cat cta gaa gct ctt tgt gaa gag gac tta ctt ctc tgg atc     1444
 Ala Leu His Leu Glu Ala Leu Cys Glu Glu Asp Leu Leu Leu Trp Ile
     380                 385                 390

 cag aaa cac aca gaa gta gaa aca gta gac ctt gtc ttg aag ctg aaa     1492
 Gln Lys His Thr Glu Val Glu Thr Val Asp Leu Val Leu Lys Leu Lys
 395                 400                 405                 410

 aat aag ctg ttg cag gct gat cga gag cac tta cct gtg aaa cct gac     1540
 Asn Lys Leu Leu Gln Ala Asp Arg Glu His Leu Pro Val Lys Pro Asp
                 415                 420                 425

 act atg gaa aag tta cgg aca cac ata gat gcc att atc tta gca ttg     1588
 Thr Met Glu Lys Leu Arg Thr His Ile Asp Ala Ile Ile Leu Ala Leu
             430                 435                 440

 cca gag gac ttg caa ggc ata ctg ctc aaa acg ggc atg aca tga tat     1636
 Pro Glu Asp Leu Gln Gly Ile Leu Leu Lys Thr Gly Met Thr 
         445                 450                 455

 ttgccaagat tttccagcca aaaaggatta tgcatcatga agcatactga catttcaacc   1696

 agacgcacaa aggagatctc tcagtggcag cggagtggan attgccatga atgctagtta   1756

 gggtagaaag actgtattgt atanacagac ctttttagtg cattactttt taaagtggat   1816

 atctgtggtg ggttcacttt atactgaaac accgg                              1851




      <210> 44
      <211> 1200
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (1)..(1200)

      <400> 44
  atg tct gcc agg ggg agg tgg gaa gga ggt ggg agg agg gcg tgc aga      48
  Met Ser Ala Arg Gly Arg Trp Glu Gly Gly Gly Arg Arg Ala Cys Arg
    1               5                  10                  15

 ggc agt ctg ggc ttg gcc aga gct cag ggt gct gag cgt gtg acc agc       96
 Gly Ser Leu Gly Leu Ala Arg Ala Gln Gly Ala Glu Arg Val Thr Ser
              20                  25                  30

 agt gag cag agg ccg gcc atg gcc agc ctg ggg ctg ctg ctc ctg ctc      144
 Ser Glu Gln Arg Pro Ala Met Ala Ser Leu Gly Leu Leu Leu Leu Leu
          35                  40                  45

 tta ctg aca gca ctg cca ccg ctg tgg tcc tcc tca ctg cct ggg ctg      192
 Leu Leu Thr Ala Leu Pro Pro Leu Trp Ser Ser Ser Leu Pro Gly Leu
      50                  55                  60

 gac act gct gaa agt aaa gcc acc att gca gac ctg atc ctg tct gcg      240
 Asp Thr Ala Glu Ser Lys Ala Thr Ile Ala Asp Leu Ile Leu Ser Ala
  65                  70                  75                  80

 ctg gag aga gcc acc gtc ttc cta gaa cag agg ctg cct gaa atc aac      288
 Leu Glu Arg Ala Thr Val Phe Leu Glu Gln Arg Leu Pro Glu Ile Asn
                  85                  90                  95

 ctg gat ggc atg gtg ggg gtc cga gtg ctg gaa gag cag cta aaa agt      336
 Leu Asp Gly Met Val Gly Val Arg Val Leu Glu Glu Gln Leu Lys Ser
             100                 105                 110

 gtc cgg gag aag tgg gcc cag gag ccc ctg ctg cag ccg ctg agc ctg      384
 Val Arg Glu Lys Trp Ala Gln Glu Pro Leu Leu Gln Pro Leu Ser Leu
         115                 120                 125

 cgc gtg ggg atg ctg ggg gag aag ctg gag gct gcc atc cag aga tcc      432
 Arg Val Gly Met Leu Gly Glu Lys Leu Glu Ala Ala Ile Gln Arg Ser
     130                 135                 140

 ctc cac tac ctc aag ctg agt gat ccc aag tac cta aga gag ttc cag      480
 Leu His Tyr Leu Lys Leu Ser Asp Pro Lys Tyr Leu Arg Glu Phe Gln
 145                 150                 155                 160

 ctg acc ctc cag ccc ggg ttt tgg aag ctc cca cat gcc tgg atc cac      528
 Leu Thr Leu Gln Pro Gly Phe Trp Lys Leu Pro His Ala Trp Ile His
                 165                 170                 175

 act gat gcc tcc ttg gtg tac ccc acg ttc ggg ccc cag gac tca ttc      576
 Thr Asp Ala Ser Leu Val Tyr Pro Thr Phe Gly Pro Gln Asp Ser Phe
             180                 185                 190

 tca gag gag aga agt gac gtg tgc ctg gtg cag ctg ctg gga acc ggg      624
 Ser Glu Glu Arg Ser Asp Val Cys Leu Val Gln Leu Leu Gly Thr Gly
         195                 200                 205

 acg gac agc agc gag ccc tgc ggc ctc tca gac ctc tgc agg agc ctc      672
 Thr Asp Ser Ser Glu Pro Cys Gly Leu Ser Asp Leu Cys Arg Ser Leu
     210                 215                 220

 atg acc aag ccc ggc tgc tca ggc tac tgc ctg tcc cac caa ctg ctc      720
 Met Thr Lys Pro Gly Cys Ser Gly Tyr Cys Leu Ser His Gln Leu Leu
 225                 230                 235                 240

 ttc ttc ctc tgg gcc aga atg agg ggg tgc aca cag gga cca ctc caa      768
 Phe Phe Leu Trp Ala Arg Met Arg Gly Cys Thr Gln Gly Pro Leu Gln
                 245                 250                 255

 cag agc cag gac tat atc aac ctc ttc tgc gcc aac atg atg gac ttg      816
 Gln Ser Gln Asp Tyr Ile Asn Leu Phe Cys Ala Asn Met Met Asp Leu
             260                 265                 270

 aac cgc aga gct gag gcc atc gga tac gcc tac cct acc cgg gac atc      864
 Asn Arg Arg Ala Glu Ala Ile Gly Tyr Ala Tyr Pro Thr Arg Asp Ile
         275                 280                 285

 ttc atg gaa aac atc atg ttc tgt gga atg ggc ggc ttc tcc gac ttc      912
 Phe Met Glu Asn Ile Met Phe Cys Gly Met Gly Gly Phe Ser Asp Phe
     290                 295                 300

 tac aag ctc cgg tgg ctg gag gcc att ctc agc tgg cag aaa cag cag      960
 Tyr Lys Leu Arg Trp Leu Glu Ala Ile Leu Ser Trp Gln Lys Gln Gln
 305                 310                 315                 320

 gaa gga tgc ttc ggg gag cct gat gct gaa gat gaa gaa tca tct aaa     1008
 Glu Gly Cys Phe Gly Glu Pro Asp Ala Glu Asp Glu Glu Ser Ser Lys
                 325                 330                 335

 gct att caa tat cag cag cat ttt tcg agg aga gtg aag agg cga gaa     1056
 Ala Ile Gln Tyr Gln Gln His Phe Ser Arg Arg Val Lys Arg Arg Glu
             340                 345                 350

 aaa caa ttt cca gat ggc tgc tcc tcc cac aac aca gcc aca gca gtg     1104
 Lys Gln Phe Pro Asp Gly Cys Ser Ser His Asn Thr Ala Thr Ala Val
         355                 360                 365

 gca gcc ctg ggt ggc ttc cta tac atc ctg gca gaa tac ccc cca gca     1152
 Ala Ala Leu Gly Gly Phe Leu Tyr Ile Leu Ala Glu Tyr Pro Pro Ala
     370                 375                 380

 aac aga gag cca cac cca tcc aca ccg cca cca cca agc agc cgc tga     1200
 Asn Arg Glu Pro His Pro Ser Thr Pro Pro Pro Pro Ser Ser Arg 
 385                 390                 395





      <210> 45
      <211> 1131
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (196)..(1131)

      <400> 45
 caggcacatc caaaaaggat ggacgagaca ccgaagcaga ggatacagga ggattaaagg     60

 attcaggaaa gcaagcagcc ctccggagaa gctgtcgaaa ttcaagactg gcaagagaag    120

 caaattcaac ctctcacacc gatcatttct cattccctga aaagaagaga ttgtttcccc    180

 agggaagtga aaata atg aac ttt tgg agg tac tgc ttt ttt gct tcc act     231
                  Met Asn Phe Trp Arg Tyr Cys Phe Phe Ala Ser Thr
                    1               5                  10

 ctg ctc agc gtg gtc att ttt gtg aga ttt tac agt agc caa ttg agc      279
 Leu Leu Ser Val Val Ile Phe Val Arg Phe Tyr Ser Ser Gln Leu Ser
          15                  20                  25

 ccg cca aaa agt tat gag aag ctg aac agt tcc agt gaa agg tat ttt      327
 Pro Pro Lys Ser Tyr Glu Lys Leu Asn Ser Ser Ser Glu Arg Tyr Phe
      30                  35                  40

 agg aaa act gcc tgt aat cac gcc tta gag aaa atg cca gtc ttt ttg      375
 Arg Lys Thr Ala Cys Asn His Ala Leu Glu Lys Met Pro Val Phe Leu
  45                  50                  55                  60

 tgg gaa aat ata tta cca tca cct ttg cga agt gtc cct tgc aag gat      423
 Trp Glu Asn Ile Leu Pro Ser Pro Leu Arg Ser Val Pro Cys Lys Asp
                  65                  70                  75

 tac ctg acc cag aat cac tac atc aca agt ccc ctg tcg gaa gaa gag      471
 Tyr Leu Thr Gln Asn His Tyr Ile Thr Ser Pro Leu Ser Glu Glu Glu
              80                  85                  90

 gct gca ttc cct ttg gcc tat gtc atg gtc atc cat aag gac ttt gac      519
 Ala Ala Phe Pro Leu Ala Tyr Val Met Val Ile His Lys Asp Phe Asp
          95                 100                 105

 acc ttt gaa agg ctc ttt agg gct atc tat atg ccc caa aat gtc tac      567
 Thr Phe Glu Arg Leu Phe Arg Ala Ile Tyr Met Pro Gln Asn Val Tyr
     110                 115                 120

 tgt gtt cac gtg gat gag aaa gcc cca gct gag tat aag gaa tct gtg      615
 Cys Val His Val Asp Glu Lys Ala Pro Ala Glu Tyr Lys Glu Ser Val
 125                 130                 135                 140

 agg cag tta ctg agt tgc ttc caa aat gct ttc att gct tca aag aca      663
 Arg Gln Leu Leu Ser Cys Phe Gln Asn Ala Phe Ile Ala Ser Lys Thr
                 145                 150                 155

 gag tct gtg gtt tat gca ggc att tcc aga ctc cag gct gac ctg aac      711
 Glu Ser Val Val Tyr Ala Gly Ile Ser Arg Leu Gln Ala Asp Leu Asn
             160                 165                 170

 tgt ctg aaa gac ctt gtc gcc tct gag gtt ccc tgg aag tac gtc atc      759
 Cys Leu Lys Asp Leu Val Ala Ser Glu Val Pro Trp Lys Tyr Val Ile
         175                 180                 185

 aac acc tgt gga caa gac ttc ccc ctg aaa acc aac cgg gag ata gtt      807
 Asn Thr Cys Gly Gln Asp Phe Pro Leu Lys Thr Asn Arg Glu Ile Val
     190                 195                 200

 cag cat ctg aaa gga ttt aaa ggg aaa aat atc acc cca ggg gtg ctg      855
 Gln His Leu Lys Gly Phe Lys Gly Lys Asn Ile Thr Pro Gly Val Leu
 205                 210                 215                 220

 cct cct gac cat gca att aag cga act aaa tat gtc cac caa gag cgt      903
 Pro Pro Asp His Ala Ile Lys Arg Thr Lys Tyr Val His Gln Glu Arg
                 225                 230                 235

 aca gat aaa ggt ggc ttt ttt gtg aaa aat act aat att ttg aaa act      951
 Thr Asp Lys Gly Gly Phe Phe Val Lys Asn Thr Asn Ile Leu Lys Thr
             240                 245                 250

 tca cct cca cat cag ctg acc atc tac ttt ggc act gcc tat gtg gcg      999
 Ser Pro Pro His Gln Leu Thr Ile Tyr Phe Gly Thr Ala Tyr Val Ala
         255                 260                 265

 ctt acc aga gag ttt gtc gac ttt gtt cta cgt gac caa agg gcc att     1047
 Leu Thr Arg Glu Phe Val Asp Phe Val Leu Arg Asp Gln Arg Ala Ile
     270                 275                 280

 gat cta cta caa tgg tca aaa gat acc tat agt cct gat gag cat ttc     1095
 Asp Leu Leu Gln Trp Ser Lys Asp Thr Tyr Ser Pro Asp Glu His Phe
 285                 290                 295                 300

 tgg gtg aca ctt aat agg gtt tca ggt agg tac taa                     1131
 Trp Val Thr Leu Asn Arg Val Ser Gly Arg Tyr 
                 305                 310





      <210> 46
      <211> 1039
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (231)..(845)

      <400> 46
 ccagggggct ggaagtggaa gcgcagcggc agaaggagag ggagagagaa agagagagag     60

 gctaattaaa aaaggatact ccgagggaag agagcaaggg cggtgcgccg ccaaggacca    120

 actagcggcg gagcttcgat cttgcctagg cgcggagagc tcccaacctg ggctggaacc    180

 ttgcccagca caggtggctg ctacacccca tgtaaaaagc ggaaaataaa   atg aag     236
                                                          Met Lys
                                                            1

 att ttc cag cgc aag atg cgg tac tgg ttg ctt cca cct ttt ttg gca      284
 Ile Phe Gln Arg Lys Met Arg Tyr Trp Leu Leu Pro Pro Phe Leu Ala
           5                  10                  15

 att gtt tat ttc tgc acc att gtc caa ggt caa gtg gct cca ccc aca      332
 Ile Val Tyr Phe Cys Thr Ile Val Gln Gly Gln Val Ala Pro Pro Thr
      20                  25                  30

 agg tta aga tat aat gta ata tct cat gac agt ata cag att tca tgg      380
 Arg Leu Arg Tyr Asn Val Ile Ser His Asp Ser Ile Gln Ile Ser Trp
  35                  40                  45                  50

 aag gct cca aga ggg aaa ttt ggt ggt tac aaa ctt ctt gtg act cca      428
 Lys Ala Pro Arg Gly Lys Phe Gly Gly Tyr Lys Leu Leu Val Thr Pro
                  55                  60                  65

 act tca ggt gga aaa act aac cag ctg aat ctg cag aac act gca act      476
 Thr Ser Gly Gly Lys Thr Asn Gln Leu Asn Leu Gln Asn Thr Ala Thr
              70                  75                  80

 aaa gca att att caa ggc ctt atg cca gac cag aat tac aca gtt caa      524
 Lys Ala Ile Ile Gln Gly Leu Met Pro Asp Gln Asn Tyr Thr Val Gln
          85                  90                  95

 att att gca tac aat aaa gat aaa gaa agc aag cca gct caa ggc caa      572
 Ile Ile Ala Tyr Asn Lys Asp Lys Glu Ser Lys Pro Ala Gln Gly Gln
     100                 105                 110

 ttc aga att aaa gat tta gaa aaa aaa aag gat cca aag ccc aga gtc      620
 Phe Arg Ile Lys Asp Leu Glu Lys Lys Lys Asp Pro Lys Pro Arg Val
 115                 120                 125                 130

 aaa gtt gtg gac aga gga aat ggg agt aga cca tct tca cca gaa gaa      668
 Lys Val Val Asp Arg Gly Asn Gly Ser Arg Pro Ser Ser Pro Glu Glu
                 135                 140                 145

 gtg aac ttg gct gtg gaa tcc cgc aat gct gac att gta gac cgg cgc      716
 Val Asn Leu Ala Val Glu Ser Arg Asn Ala Asp Ile Val Asp Arg Arg
             150                 155                 160

 agg tgc acg gag aat tgg aga atc cct cga acg gtg cgg caa ctt ctt      764
 Arg Cys Thr Glu Asn Trp Arg Ile Pro Arg Thr Val Arg Gln Leu Leu
         165                 170                 175

 ggg gca gac ccc ggg ggt cac gcg att ctc gag gtg ggg cgc cac gaa      812
 Gly Ala Asp Pro Gly Gly His Ala Ile Leu Glu Val Gly Arg His Glu
     180                 185                 190

 aga aga cca cat ggg tcg ttg cga cag aca tag tggcgaag ccagaaatta      863
 Arg Arg Pro His Gly Ser Leu Arg Gln Thr 
 195                 200

 aagggcgggc tgacggcaac ttcccacaaa agagcctggt ctgaacacgg tgaacaccgc    923

 acataggagg cgagaggcac gacagggcgg tagtgagaca gagataggga gaggctgacc    983

 caaagaagaa cgagaacgag agccacaggt aggcgtcgtc agtaggcaca agcata       1039




      <210> 47
      <211> 2149
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (165)..(1637)

      <400> 47
 ctaatcaaga ggatgttata aagcatgagt cagacagcct ctggctttct ggaagggcaa     60

 ggactctata tatacagagg gagcttccta gctgggatat tggagcagca agaggctggg    120

 aagccatcac ttaccttgca ctgagaaaga agacaaaggc cagt atg cac agc ttt     176
                                                  Met His Ser Phe
                                                    1

 cct cca ctg ctg ctg ctg ctg ttc tgg ggt gtg gtg tct cac agc ttc      224
 Pro Pro Leu Leu Leu Leu Leu Phe Trp Gly Val Val Ser His Ser Phe
   5                  10                  15                  20

 cca gcg act cta gaa aca cac aga gca aga tgt gga ctt agt cca gaa      272
 Pro Ala Thr Leu Glu Thr His Arg Ala Arg Cys Gly Leu Ser Pro Glu
                  25                  30                  35

 aca gca ccc tcc acc caa aat gta tct agc cat gca tac gct ctc ttt      320
 Thr Ala Pro Ser Thr Gln Asn Val Ser Ser His Ala Tyr Ala Leu Phe
              40                  45                  50

 tcc cag ttg gag aaa tac ctg gaa aaa tac tac aac ctg aag aat gat      368
 Ser Gln Leu Glu Lys Tyr Leu Glu Lys Tyr Tyr Asn Leu Lys Asn Asp
          55                  60                  65

 ggg agg caa gtt gaa aag cgg aga aat agt ggc cca gtg gtt gaa aaa      416
 Gly Arg Gln Val Glu Lys Arg Arg Asn Ser Gly Pro Val Val Glu Lys
      70                  75                  80

 ttg aag caa atg cag gaa ttc ttt ggg ctg aaa gtg act ggg aaa cca      464
 Leu Lys Gln Met Gln Glu Phe Phe Gly Leu Lys Val Thr Gly Lys Pro
  85                  90                  95                 100

 gat gct gaa acc ctg aag gtg atg aag cag ccc aga tgt gga gtg cct      512
 Asp Ala Glu Thr Leu Lys Val Met Lys Gln Pro Arg Cys Gly Val Pro
                 105                 110                 115

 gat gtg gct cag ttt gtc ctc act gag ggg aac cct cgc tgg gag caa      560
 Asp Val Ala Gln Phe Val Leu Thr Glu Gly Asn Pro Arg Trp Glu Gln
             120                 125                 130

 aca cat ctg acc tac agg att gaa aat tac acg cca gat ttg cca aga      608
 Thr His Leu Thr Tyr Arg Ile Glu Asn Tyr Thr Pro Asp Leu Pro Arg
         135                 140                 145

 gca gat gtg gac cat gcc att gag aaa gcc ttc caa ctc tgg agt aat      656
 Ala Asp Val Asp His Ala Ile Glu Lys Ala Phe Gln Leu Trp Ser Asn
     150                 155                 160

 gtc aca cct ctg aca ttc acc aag gtc tct gag ggt caa gca gac atc      704
 Val Thr Pro Leu Thr Phe Thr Lys Val Ser Glu Gly Gln Ala Asp Ile
 165                 170                 175                 180

 atg ata tct ttt gtc agg gga gat cat cgg gac aac tct cct ttt gat      752
 Met Ile Ser Phe Val Arg Gly Asp His Arg Asp Asn Ser Pro Phe Asp
                 185                 190                 195

 gga cct gga gga aat ctt gct cat gct ttt caa cca ggc cca ggt att      800
 Gly Pro Gly Gly Asn Leu Ala His Ala Phe Gln Pro Gly Pro Gly Ile
             200                 205                 210

 gga ggg gat gct cat ttt gat gaa gat gaa agg tgg acc aac aat ttc      848
 Gly Gly Asp Ala His Phe Asp Glu Asp Glu Arg Trp Thr Asn Asn Phe
         215                 220                 225

 aga gag tac aac tta cat cgt gtt gcg gct cat gaa ctc ggc cat tct      896
 Arg Glu Tyr Asn Leu His Arg Val Ala Ala His Glu Leu Gly His Ser
     230                 235                 240

 ctt gga ctc tcc cat tct act gat atc ggg gct ttg atg tac cct agc      944
 Leu Gly Leu Ser His Ser Thr Asp Ile Gly Ala Leu Met Tyr Pro Ser
 245                 250                 255                 260

 tac acc ttc agt ggt gat gtt cag cta gct cag gat gac att gat ggc      992
 Tyr Thr Phe Ser Gly Asp Val Gln Leu Ala Gln Asp Asp Ile Asp Gly
                 265                 270                 275

 atc caa gcc ata tat gga cgt tcc caa aat cct gtc cag ccc atc ggc     1040
 Ile Gln Ala Ile Tyr Gly Arg Ser Gln Asn Pro Val Gln Pro Ile Gly
             280                 285                 290

 cca caa acc cca aaa gcg tgt gac agt aag cta acc ttt gat gct ata     1088
 Pro Gln Thr Pro Lys Ala Cys Asp Ser Lys Leu Thr Phe Asp Ala Ile
         295                 300                 305

 act acg att cgg gga gaa gtg atg ttc ttt aaa gac aga ttc tac atg     1136
 Thr Thr Ile Arg Gly Glu Val Met Phe Phe Lys Asp Arg Phe Tyr Met
     310                 315                 320

 cgc aca aat ccc ttc tac ccg gaa gtt gag ctc aat ttc att tct gtt     1184
 Arg Thr Asn Pro Phe Tyr Pro Glu Val Glu Leu Asn Phe Ile Ser Val
 325                 330                 335                 340

 ttc tgg cca caa ctg cca aat ggg ctt gaa gct gct tac gaa ttt gcc     1232
 Phe Trp Pro Gln Leu Pro Asn Gly Leu Glu Ala Ala Tyr Glu Phe Ala
                 345                 350                 355

 gac aga gat gaa gtc cgg ttt ttc aaa ggg aat aag tac tgg gct gtt     1280
 Asp Arg Asp Glu Val Arg Phe Phe Lys Gly Asn Lys Tyr Trp Ala Val
             360                 365                 370

 cag gga cag aat gtg cta cac gga tac ccc aag gac atc tac agc tcc     1328
 Gln Gly Gln Asn Val Leu His Gly Tyr Pro Lys Asp Ile Tyr Ser Ser
         375                 380                 385

 ttt ggc ttc cct aga act gtg aag cat atc gat gct gct ctt tct gag     1376
 Phe Gly Phe Pro Arg Thr Val Lys His Ile Asp Ala Ala Leu Ser Glu
     390                 395                 400

 gaa aac act gga aaa acc tac ttc ttt gtt gct aac aaa tac tgg agg     1424
 Glu Asn Thr Gly Lys Thr Tyr Phe Phe Val Ala Asn Lys Tyr Trp Arg
 405                 410                 415                 420

 tat gat gaa tat aaa cga tct atg gat cca ggt tat ccc aaa atg ata     1472
 Tyr Asp Glu Tyr Lys Arg Ser Met Asp Pro Gly Tyr Pro Lys Met Ile
                 425                 430                 435

 gca cat gac ttt cct gga att ggc cac aaa gtt gat gca gtt ttc atg     1520
 Ala His Asp Phe Pro Gly Ile Gly His Lys Val Asp Ala Val Phe Met
             440                 445                 450

 aaa gat gga ttt ttc tat ttc ttt cat gga aca aga caa tac aaa ttt     1568
 Lys Asp Gly Phe Phe Tyr Phe Phe His Gly Thr Arg Gln Tyr Lys Phe
         455                 460                 465

 gat cct aaa acg aag aga att ttg act ctc cag aaa gct aat agc tgg     1616
 Asp Pro Lys Thr Lys Arg Ile Leu Thr Leu Gln Lys Ala Asn Ser Trp
     470                 475                 480

 ttc aac tgc agg aaa aat tga ac attactaatt tgaatggaaa acacatggtg     1669
 Phe Asn Cys Arg Lys Asn 
 485                 490

 tgagtccaaa gaaggtgttt tcctgaagaa ctgtctattt tctcagtcat ttttaacctc   1729

 tagagtcact gatacacaga atataatctt atttatacct cagtttgcat atttttttac   1789

 tatttagaat gtagcccttt ttgtactgat ataatttagt tccacaaatg gtgggtacaa   1849

 aaagtcaagt ttgtggctta tggattcata taggccagag ttgcaaagat cttttccaga   1909

 gtatgcaact ctgacgttga tcccagagag cagcttcagt gacaaacata tcctttcaag   1969

 acagaaagag acaggagaca tgagtctttg ccggaggaaa agcagctcaa gaacacatgt   2029

 gcagtcactg gtgtcaccct ggataggcaa gggataactc ttctaacaca aaataagtgt   2089

 tttatgtttg gaataaagtc aaccttgttt ctactgtttt aaaaaaaaaa aaaaaaaaaa   2149




      <210> 48
      <211> 609
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (1)..(609)

      <400> 48
  atg cgg gtt gga cgc cgt ccc aaa gca cag agg gtg cag ggc cag aac      48
  Met Arg Val Gly Arg Arg Pro Lys Ala Gln Arg Val Gln Gly Gln Asn
    1               5                  10                  15

 ggc aac cac tca agt gac tca gaa gga agc ttc tct tta ctg tgc tta       96
 Gly Asn His Ser Ser Asp Ser Glu Gly Ser Phe Ser Leu Leu Cys Leu
              20                  25                  30

 caa ctt ttc tcc aag ttt gcg gtg gtt tcc ata ttg tta ttg tta ttg      144
 Gln Leu Phe Ser Lys Phe Ala Val Val Ser Ile Leu Leu Leu Leu Leu
          35                  40                  45

 tta tta ttc aac acg agt aaa aag aaa ctc atg acc ttc tcc ttg gac      192
 Leu Leu Phe Asn Thr Ser Lys Lys Lys Leu Met Thr Phe Ser Leu Asp
      50                  55                  60

 tcg ctc ctc tcc cca atc tcg ata ccg act gca ctg ttg ttc ggg tcg      240
 Ser Leu Leu Ser Pro Ile Ser Ile Pro Thr Ala Leu Leu Phe Gly Ser
  65                  70                  75                  80

 ccc cct ccc cca cca tcc cac agg ggc tat ggc gtg ggc tca gca cct      288
 Pro Pro Pro Pro Pro Ser His Arg Gly Tyr Gly Val Gly Ser Ala Pro
                  85                  90                  95

 ctg aag gaa aag cag atg aaa gaa ctt gtg cct ccc agg cga gaa tgc      336
 Leu Lys Glu Lys Gln Met Lys Glu Leu Val Pro Pro Arg Arg Glu Cys
             100                 105                 110

 aca gtg cag ggg caa ccc tgg cag ggc cca tcc ctt cct ggt ccc gct      384
 Thr Val Gln Gly Gln Pro Trp Gln Gly Pro Ser Leu Pro Gly Pro Ala
         115                 120                 125

 gag ctc ggg cac aga ccg ggc acc agg ctc ggt gtg gag tgt gat ggg      432
 Glu Leu Gly His Arg Pro Gly Thr Arg Leu Gly Val Glu Cys Asp Gly
     130                 135                 140

 gag tgg tgt ccc cgg agt tgt ttc tgg gag ttg ctg ggt cca cct tac      480
 Glu Trp Cys Pro Arg Ser Cys Phe Trp Glu Leu Leu Gly Pro Pro Tyr
 145                 150                 155                 160

 ctt aaa tgt agt caa cca agt ccc atc cca cca cta gat ggc acc caa      528
 Leu Lys Cys Ser Gln Pro Ser Pro Ile Pro Pro Leu Asp Gly Thr Gln
                 165                 170                 175

 acc tca gca gaa agg ggg cgt ggg ttg gcc cct gaa gtg aga aaa cca      576
 Thr Ser Ala Glu Arg Gly Arg Gly Leu Ala Pro Glu Val Arg Lys Pro
             180                 185                 190

 ttg gtc aat ctg gac ctg gcg tgc ttc agg tga                          609
 Leu Val Asn Leu Asp Leu Ala Cys Phe Arg 
         195                 200





      <210> 49
      <211> 1165
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (261)..(710)

      <400> 49
 ggaaatggtg agcgtgcgcc ggggtcttgt ggctggcggc cgcccaccac cccacgccag     60

 gccttcagtc ttccgaggat gaggggatct cagagctccg gacagggaat cggtggtggc    120

 tgggcgtggc cgggcccggg ccccagccga cttgagggtg gaacccggcg gcggaggcct    180

 ctaaagcctg accgaggcgg ggccgccgga tcccgctgcc ccttgaccgg aagcgggagc    240

 ccagcctcgg ccaggaagag    atg atg ggc gag ggg tgg gcg gcg gcc ctg     290
                          Met Met Gly Glu Gly Trp Ala Ala Ala Leu
                            1               5                  10

 cag cct aga gtt ttg ggg cct tgg tgc gcg atg gca acc ctg gca acg      338
 Gln Pro Arg Val Leu Gly Pro Trp Cys Ala Met Ala Thr Leu Ala Thr
                  15                  20                  25

 ttt ccc ggg agc tca gtt tgt ggc agg ctc tgc caa gca ctt tat gta      386
 Phe Pro Gly Ser Ser Val Cys Gly Arg Leu Cys Gln Ala Leu Tyr Val
              30                  35                  40

 tct tgt att tcc tcc gcc tcc tcc cag ctc tgt gag gca gag gtg gag      434
 Ser Cys Ile Ser Ser Ala Ser Ser Gln Leu Cys Glu Ala Glu Val Glu
          45                  50                  55

 gag aca ctg aag cga ctg cag agc cag aag gga gtg cag gga atc atc      482
 Glu Thr Leu Lys Arg Leu Gln Ser Gln Lys Gly Val Gln Gly Ile Ile
      60                  65                  70

 gtc gtg aac aca gaa ggc att ccc atc aag agc acc atg gac aac ccc      530
 Val Val Asn Thr Glu Gly Ile Pro Ile Lys Ser Thr Met Asp Asn Pro
  75                  80                  85                  90

 acc acc acc cag tat gcc agc ctc atg cac agc ttc atc ctg aag gca      578
 Thr Thr Thr Gln Tyr Ala Ser Leu Met His Ser Phe Ile Leu Lys Ala
                  95                 100                 105

 cgg agc acc gtg cgt gac atc gac ccc cag aac gat ctc acc ttc ctt      626
 Arg Ser Thr Val Arg Asp Ile Asp Pro Gln Asn Asp Leu Thr Phe Leu
             110                 115                 120

 cga att cgc tcc aag aaa aat gaa ctt atg gtt gca cca gat aaa gac      674
 Arg Ile Arg Ser Lys Lys Asn Glu Leu Met Val Ala Pro Asp Lys Asp
         125                 130                 135

 tat ttc ctg att gtg att cag aat cca acc gaa taa gcca ctctctgggc      724
 Tyr Phe Leu Ile Val Ile Gln Asn Pro Thr Glu 
     140                 145

 tccctgtgtc attccttaat ttaatgcccc caagaatgtt catgtccatc atgtcagtgg    784

 gactagcaca tgggaagtcg ctgggaacca atcaaaccaa tccagtgacc gtgtgtgggg    844

 ctgggggctc tcttccccac caaggtaact ccgttggtgt ccaaactttc ccagagatcc    904

 gggaggcctt ctcaattcag gtgttggggc aaagcttgtt tgaaggccgg ccaagttctt    964

 tggactcagt gattttggcg ctcgggagaa agggtgtctt tcaaagaaac aatgggtgaa   1024

 gaaacaaatg gggcgttgtg gtgggggaag ggagagaggg gatgtgtcac ccattcatag   1084

 aggggctagt agaagatctt aatcagtgag atgatagaca gagagagcgg agaaagcaag   1144

 aacgaggggt tgagaacgag a                                             1165




      <210> 50
      <211> 520
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (101)..(520)

      <400> 50
 ttagggtctg tttgtgttgc atatgtcaat cttttgtcca tctgtgttgg cgtggtcttc     60

 ctttcctttg tctgggttga aatcatgttt atttgtgtaa  atg cag ctc cgc atg     115
                                              Met Gln Leu Arg Met
                                                1               5

 atg tgt gcc tca ctg ttc gcc atc acc agt ggc agt cag cat gac ctg      163
 Met Cys Ala Ser Leu Phe Ala Ile Thr Ser Gly Ser Gln His Asp Leu
                  10                  15                  20

 cgg tgg gcc ctc ttt tgc agc tgt agt ttt act gtc tgc cat ccc ttc      211
 Arg Trp Ala Leu Phe Cys Ser Cys Ser Phe Thr Val Cys His Pro Phe
              25                  30                  35

 agc atg gca gtc tac ttt gtg tat caa ata aaa aga aat gga atg aca      259
 Ser Met Ala Val Tyr Phe Val Tyr Gln Ile Lys Arg Asn Gly Met Thr
          40                  45                  50

 gct gag gcc cac agt gtc cat ctg tgg acc cac aac tca acc ctc ctg      307
 Ala Glu Ala His Ser Val His Leu Trp Thr His Asn Ser Thr Leu Leu
      55                  60                  65

 ggg gaa ctc ctc tat cat cct ggc tcc aag gac cac cta tgc aaa agt      355
 Gly Glu Leu Leu Tyr His Pro Gly Ser Lys Asp His Leu Cys Lys Ser
  70                  75                  80                  85

 gaa ggc aag ctg tgt aga atc aaa gct gag gtg tct agg aat ttt cag      403
 Glu Gly Lys Leu Cys Arg Ile Lys Ala Glu Val Ser Arg Asn Phe Gln
                  90                  95                 100

 tac tat ggt gct tat gct tct ctt cta cgc ctt atg gaa gta ttt aga      451
 Tyr Tyr Gly Ala Tyr Ala Ser Leu Leu Arg Leu Met Glu Val Phe Arg
             105                 110                 115

 aag gaa aaa gaa agc caa act gcg tac aca gag tgt gag gag ggt gaa      499
 Lys Glu Lys Glu Ser Gln Thr Ala Tyr Thr Glu Cys Glu Glu Gly Glu
         120                 125                 130

 gaa aac act caa gga ttt taa                                          520
 Glu Asn Thr Gln Gly Phe 
     135





      <210> 51
      <211> 2262
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (117)..(1043)

      <400> 51
 tgcggaattc cgcacgagcc ggcccccaag tcccgcgcgg gccggccagg ggcggggcgt     60

 cgggccagct gagctatccc gtcagaccgc gccagtttga atgaaagctc tacaag        116                                                                 
 atg gcg gcg gtc ggg gcc gag gcg cga gga gct tgg tgt gtg cct tgc      164
 Met Ala Ala Val Gly Ala Glu Ala Arg Gly Ala Trp Cys Val Pro Cys
   1               5                  10                  15

 cta gtt tca ctt gat act ctt cag gaa tta tgt aga aaa gaa aag ctc      212
 Leu Val Ser Leu Asp Thr Leu Gln Glu Leu Cys Arg Lys Glu Lys Leu
              20                  25                  30

 aca tgt aaa tcg att gga atc acc aaa agg aat cta aac aat tat gag      260
 Thr Cys Lys Ser Ile Gly Ile Thr Lys Arg Asn Leu Asn Asn Tyr Glu
          35                  40                  45

 gtg gaa tac ttg tgt gac tac aag gta gta aag gat atg gaa tat tat      308
 Val Glu Tyr Leu Cys Asp Tyr Lys Val Val Lys Asp Met Glu Tyr Tyr
      50                  55                  60

 ctt gta aaa tgg aaa gga tgg cca gat tct aca aat act tgg gaa cct      356
 Leu Val Lys Trp Lys Gly Trp Pro Asp Ser Thr Asn Thr Trp Glu Pro
  65                  70                  75                  80

 ttg caa aat ctg aag tgc ccg tta ctg ctt cag caa ttc tct aat gac      404
 Leu Gln Asn Leu Lys Cys Pro Leu Leu Leu Gln Gln Phe Ser Asn Asp
                  85                  90                  95

 aag cat aat tat tta tct cag gta aag aaa ggc aaa gca ata act cca      452
 Lys His Asn Tyr Leu Ser Gln Val Lys Lys Gly Lys Ala Ile Thr Pro
             100                 105                 110

 aaa gac aat aac aaa act ttg aaa cct gcc att gct gag tac att gtg      500
 Lys Asp Asn Asn Lys Thr Leu Lys Pro Ala Ile Ala Glu Tyr Ile Val
         115                 120                 125

 aag aag gct aaa caa agg ata gct ctg cag aga tgg caa gat gaa ctc      548
 Lys Lys Ala Lys Gln Arg Ile Ala Leu Gln Arg Trp Gln Asp Glu Leu
     130                 135                 140

 aac aga aga aag aat cat aaa gga atg ata ttt gtt gaa aat act gtt      596
 Asn Arg Arg Lys Asn His Lys Gly Met Ile Phe Val Glu Asn Thr Val
 145                 150                 155                 160

 gat tta gag ggc cca cct tca gac ttc tat tac att aac gaa tac aaa      644
 Asp Leu Glu Gly Pro Pro Ser Asp Phe Tyr Tyr Ile Asn Glu Tyr Lys
                 165                 170                 175

 cca gct cct gga atc agc tta gtc aat gaa gct acc ttt ggt tgt tca      692
 Pro Ala Pro Gly Ile Ser Leu Val Asn Glu Ala Thr Phe Gly Cys Ser
             180                 185                 190

 tgc aca gat tgc ttc ttt caa aaa tgt tgt cct gct gaa gct gga gtt      740
 Cys Thr Asp Cys Phe Phe Gln Lys Cys Cys Pro Ala Glu Ala Gly Val
         195                 200                 205

 ctt ttg gct tat aat aaa aac caa caa att aaa atc cca cct ggt act      788
 Leu Leu Ala Tyr Asn Lys Asn Gln Gln Ile Lys Ile Pro Pro Gly Thr
     210                 215                 220

 ccc atc tat gaa tgc aac tca agg tgt cag tgt ggt cct gat tgt ccc      836
 Pro Ile Tyr Glu Cys Asn Ser Arg Cys Gln Cys Gly Pro Asp Cys Pro
 225                 230                 235                 240

 aat agg att gta caa aaa ggc aca cag tat tcg ctt tgc atc ttt cga      884
 Asn Arg Ile Val Gln Lys Gly Thr Gln Tyr Ser Leu Cys Ile Phe Arg
                 245                 250                 255

 act agc aat gga cgt ggc tgg ggt gta aag acc ctt gtg aag att aaa      932
 Thr Ser Asn Gly Arg Gly Trp Gly Val Lys Thr Leu Val Lys Ile Lys
             260                 265                 270

 aga atg agt ttt gtc atg gaa tat gtt gga gag gta tgt ttc att tgc      980
 Arg Met Ser Phe Val Met Glu Tyr Val Gly Glu Val Cys Phe Ile Cys
         275                 280                 285

 cac gta gta aat gat gga cat gca ggt tta tac ttt tgg aaa att acc     1028
 His Val Val Asn Asp Gly His Ala Gly Leu Tyr Phe Trp Lys Ile Thr
     290                 295                 300

 ttt tta tct ctt taa gagatacttg gtacattttg atattttcat ttgcagatat     1083
 Phe Leu Ser Leu 
 305

 gtagaaattt attcagattt aggagaagag ttcactggca tatttagaaa taaaaaactt   1143

 ttatatgaat aaaaaatata cgttaaaaca aattgatata gtcatctttc aacaaataca   1203

 cattcctact agtcaaacct aggatttgta aaatttaaaa tatgacaact gtttttaccc   1263

 aaaagtccta agaagaaact cagatgtaac acatgctgct ttgaaacttg aaagttttaa   1323

 tttacttcat ctatttgacc aaatatgatt aaatgtagtt ggcagaactc tattttggat   1383

 caacatgaaa gatactatat ttatgagttt tgtaaaatat acacaagcat ttattgcatc   1443

 cataatctgt aacttacttt tgaactgtga agaccattct caaaactacc atacaaatac   1503

 tagcaaattt atttgtatac aaatcatata tatgtatata tatatataaa tgtaaaaagt   1563

 atttgccgtg tgtcacatac tattctaagc acttgatgta ttaattcact aatcctctcc   1623

 aaaactcagt gaggtagtac tgttcccctt ctttttttct tttttttcct tttttgagaa   1683

 gtactactgt tatgtccatt attgtaaaga aattggtccc ttgcccaagg tcaccaggtc   1743

 acatagtaat aagaaccgag attcaaagct ctaaaatcag tagtcttcac catggcacca   1803

 cactgcttca aactgaaggg taggttgagc tgtgactaga aagacacaag catggctaca   1863

 tatctggagt tgtcaactct ggatttttta gttggaattg ggtcacctat aattatctgt   1923

 attcatctat aattctgaaa ctaaattaga tggctgtttt gattcttaca cttttagaca   1983

 gtggtagatt attataaatt attcagtata caagatcttg tataatcaaa ttactctttt   2043

 tgttaaccaa aattttttta agttgcattc ttaatgagtg cagcagccaa atttggttgg   2103

 taacataaag tactttagac acttttggtt tcttaagccg agcgtgtcat aaaacttgtg   2163

 ttcttaagag cagaactgta gatgatgatc ttagacttac agaattgcat gaaaataaca   2223

 tattctacaa aaacaaaacc ttccattcca aagatgcgg                          2262




      <210> 52
      <211> 395
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (9)..(305)

      <400> 52
 gcgctgtc atg gcg gtt gtg ctg atg aag acc act ggc ctt gtg gga ttg      50
          Met Ala Val Val Leu Met Lys Thr Thr Gly Leu Val Gly Leu
            1               5                  10

 gct gtg tgc aat act cct aac gag agg cta aga ata ttg tcc aca aag       98
 Ala Val Cys Asn Thr Pro Asn Glu Arg Leu Arg Ile Leu Ser Thr Lys
  15                  20                  25                  30

 att ctt gat gtt ctt gag gaa atc cct aaa aat gca gca tat aga aag      146
 Ile Leu Asp Val Leu Glu Glu Ile Pro Lys Asn Ala Ala Tyr Arg Lys
                  35                  40                  45

 ttt aca gaa cag att aca aat gag aag ctg gct atg gtt aaa gcg gaa      194
 Phe Thr Glu Gln Ile Thr Asn Glu Lys Leu Ala Met Val Lys Ala Glu
              50                  55                  60

 cca gat gtt aaa aaa tta gaa gac caa ctt caa ggc ggc caa tta gaa      242
 Pro Asp Val Lys Lys Leu Glu Asp Gln Leu Gln Gly Gly Gln Leu Glu
          65                  70                  75

 gag gtg att ctt cag gct gaa cat gaa cta aat ctg gca aga cag tgg      290
 Glu Val Ile Leu Gln Ala Glu His Glu Leu Asn Leu Ala Arg Gln Trp
      80                  85                  90

 aaa tgg cca ata taa ttattaagtg actttggtgt gtcatgggaa actgatgtaa      345
 Lys Trp Pro Ile 
  95

 ttaaatattc tggtatatta agagcgtgtt cttattactg acattttgca               395




      <210> 53
      <211> 1560
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (141)..(1115)

      <400> 53
 gaatcaggaa gaccagctcc tcctactgtc ttctgtgtta cgggatcagc gttccttgtt     60

 gagtgggacc tgagttttga gagggtcttc tgctcctctt ggtctggtcc cttacttcca    120

 agagccccag agaggaaggc    atg ctg ttg gct cta gct ctg ctt cta gct     170
                          Met Leu Leu Ala Leu Ala Leu Leu Leu Ala
                            1               5                  10

 ttc ctg cct cct gcc agt cag aaa tct tcc aac ttg gaa ggg aga aca      218
 Phe Leu Pro Pro Ala Ser Gln Lys Ser Ser Asn Leu Glu Gly Arg Thr
                  15                  20                  25

 aag tca gtc acc agg cca act ggg tca tca gct gta atc act tgt gat      266
 Lys Ser Val Thr Arg Pro Thr Gly Ser Ser Ala Val Ile Thr Cys Asp
              30                  35                  40

 ctt cct gta gaa aat gcc gtc tac acc cac tgg tac cta cac cag gag      314
 Leu Pro Val Glu Asn Ala Val Tyr Thr His Trp Tyr Leu His Gln Glu
          45                  50                  55

 ggg aag gcc cca cag cgt ctt ctg tac tat gac tcc tac aac tcc agg      362
 Gly Lys Ala Pro Gln Arg Leu Leu Tyr Tyr Asp Ser Tyr Asn Ser Arg
      60                  65                  70

 gtt gtg ttg gaa tca gga atc agt cga gaa aag tat cat act tat gca      410
 Val Val Leu Glu Ser Gly Ile Ser Arg Glu Lys Tyr His Thr Tyr Ala
  75                  80                  85                  90

 agc aca ggg aag agc ctt aaa ttt ata ctg gaa aat cta att gaa cgt      458
 Ser Thr Gly Lys Ser Leu Lys Phe Ile Leu Glu Asn Leu Ile Glu Arg
                  95                 100                 105

 gac tct ggg gtc tat tac tgt gcc acc tgg aca gat agg atc tat tat      506
 Asp Ser Gly Val Tyr Tyr Cys Ala Thr Trp Thr Asp Arg Ile Tyr Tyr
             110                 115                 120

 aag aaa ctc ttt ggc agt gga aca aca ctt gtt gtc aca gat aaa caa      554
 Lys Lys Leu Phe Gly Ser Gly Thr Thr Leu Val Val Thr Asp Lys Gln
         125                 130                 135

 ctt gat gca gat gtt tcc ccc aag ccc act att ttt ctt cct tca att      602
 Leu Asp Ala Asp Val Ser Pro Lys Pro Thr Ile Phe Leu Pro Ser Ile
     140                 145                 150

 gct gaa aca aaa ctc cag aag gct gga aca tac ctt tgt ctt ctt gag      650
 Ala Glu Thr Lys Leu Gln Lys Ala Gly Thr Tyr Leu Cys Leu Leu Glu
 155                 160                 165                 170

 aaa ttt ttc cca gat att att aag ata cat tgg caa gaa aag aag agc      698
 Lys Phe Phe Pro Asp Ile Ile Lys Ile His Trp Gln Glu Lys Lys Ser
                 175                 180                 185

 aac acg att ctg gga tcc cag gag ggg aac acc atg aag act aac gac      746
 Asn Thr Ile Leu Gly Ser Gln Glu Gly Asn Thr Met Lys Thr Asn Asp
             190                 195                 200

 aca tac atg aaa ttt agc tgg tta acg gtg cca gaa gag tca ctg gac      794
 Thr Tyr Met Lys Phe Ser Trp Leu Thr Val Pro Glu Glu Ser Leu Asp
         205                 210                 215

 aaa gaa cac aga tgt atc gtc aga cat gag aat aat aaa aac gga att      842
 Lys Glu His Arg Cys Ile Val Arg His Glu Asn Asn Lys Asn Gly Ile
     220                 225                 230

 gat caa gaa att atc ttt cct cca ata aag aca gat gtc acc aca gtg      890
 Asp Gln Glu Ile Ile Phe Pro Pro Ile Lys Thr Asp Val Thr Thr Val
 235                 240                 245                 250

 gat ccc aaa gac agt tat tca aaa gat gca aat gat gtc atc aca atg      938
 Asp Pro Lys Asp Ser Tyr Ser Lys Asp Ala Asn Asp Val Ile Thr Met
                 255                 260                 265

 gat ccc aaa gac aat tgg tca aaa gat gca att gat aca cta ctg ctg      986
 Asp Pro Lys Asp Asn Trp Ser Lys Asp Ala Ile Asp Thr Leu Leu Leu
             270                 275                 280

 cag ctc aca aac acc tct gca tat tac atg tac ctc ctc ctg ctc ctc     1034
 Gln Leu Thr Asn Thr Ser Ala Tyr Tyr Met Tyr Leu Leu Leu Leu Leu
         285                 290                 295

 aag agt ggt gtc tat ttt gcc atc atc acc tgc tgt ctg ctt aga aga     1082
 Lys Ser Gly Val Tyr Phe Ala Ile Ile Thr Cys Cys Leu Leu Arg Arg
     300                 305                 310

 acg gct ttc tgc tgc aat gga gag aaa tca taa cagacggt ggcacaagga     1133
 Thr Ala Phe Cys Cys Asn Gly Glu Lys Ser 
 315                 320

 ggccatcttt tcctcatcgg ttattgtccc tagaagcgtc ttctgaggat ctagttgggc   1193

 tttctttctg ggtttgggcc atttcagttc tcatgtgtgt actattctat cattattgta   1253

 taatggtttt caaaccagtg ggcacacaga gaacctcact ctgtaataac aatgaggaat   1313

 agccatggcg atctccagca ccaatctctc catgttttcc acagctcctc cagccaaccc   1373

 aaatagcgcc tgctatagtg tagacagcct gcggcttcta gccttgtccc tctcttagtg   1433

 ttctttaatc agataactgc ctggaagcct ttcattttac acgccctgaa gcagtcttct   1493

 ttgctagttg aattatgtgg tgtgtttttc cgtaataagc aaaataaatt taaaaaaatg   1553

 aaaagtt                                                             1560




      <210> 54
      <211> 631
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (240)..(581)

      <220>
      <221> misc_feature
      <222> (1)...(631)
      <223> n = a,t,c or g

      <400> 54
 aggaattcgn gaggtctaca cccataaagt tcttggcaaa agcttggggg agaggtagaa     60

 ttatccctcc ccactggagg cgctgccgca gcccgccctc tgccagacct gcagcttcag    120

 ccccgcccac tgcctccgca ggacttgtgc cctggggctg cctggcatct gggggcctcc    180

 tcagagccag ggctctttct ggttgaggct gagactcact ggtgtcatca cgcccctcc     239                                                                 
 atg aat gag aca aac aaa aca ctt gtt ggg cct tcg gag ctc ccc aca      287
 Met Asn Glu Thr Asn Lys Thr Leu Val Gly Pro Ser Glu Leu Pro Thr
   1               5                  10                  15

 gcg tct gct gtg gcc cct ggc cca agc act ggg gct cgg gca tta gct      335
 Ala Ser Ala Val Ala Pro Gly Pro Ser Thr Gly Ala Arg Ala Leu Ala
              20                  25                  30

 gtg ctg gta aga ttt gtg ctg ggg gct gtg gtc ctc tcg ctc ctc att      383
 Val Leu Val Arg Phe Val Leu Gly Ala Val Val Leu Ser Leu Leu Ile
          35                  40                  45

 gca ctt gct gcc aaa tgc cac ctc tgc cgc cga tac cat gcc agc tac      431
 Ala Leu Ala Ala Lys Cys His Leu Cys Arg Arg Tyr His Ala Ser Tyr
      50                  55                  60

 cgg cac cgc cca ctg cct gag aca gga agg gga ggc cgc cca cag gtg      479
 Arg His Arg Pro Leu Pro Glu Thr Gly Arg Gly Gly Arg Pro Gln Val
  65                  70                  75                  80

 gct gaa gat gag gat gat gat ggc ttc atc gag gac aat tac att cag      527
 Ala Glu Asp Glu Asp Asp Asp Gly Phe Ile Glu Asp Asn Tyr Ile Gln
                  85                  90                  95

 cct ggg act ggc gag ctg ggg aca gag ggt agc agg gac cac ttc tcc      575
 Pro Gly Thr Gly Glu Leu Gly Thr Glu Gly Ser Arg Asp His Phe Ser
             100                 105                 110

 ctc tga gctcccatct ttagaccctc cccactccct ccatgcctga cagcttaagg       631
 Leu 






      <210> 55
      <211> 3933
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (1)..(1902)

      <400> 55
  atg gat tct aca acc tgc caa act att aat caa ggg tat ggt ctg aat      48
  Met Asp Ser Thr Thr Cys Gln Thr Ile Asn Gln Gly Tyr Gly Leu Asn
    1               5                  10                  15

 atg cgt tgc ttg gca gct cgg gtc aac tat aag act ttg att att atc       96
 Met Arg Cys Leu Ala Ala Arg Val Asn Tyr Lys Thr Leu Ile Ile Ile
              20                  25                  30

 tgc gca ctc ttc act ttg gtc aca gta ctt ttg tgg aat aag tgt tcc      144
 Cys Ala Leu Phe Thr Leu Val Thr Val Leu Leu Trp Asn Lys Cys Ser
          35                  40                  45

 agt gac aaa gca atc cag ttt cca cgg cgt tcg agt agt ggc ttc aga      192
 Ser Asp Lys Ala Ile Gln Phe Pro Arg Arg Ser Ser Ser Gly Phe Arg
      50                  55                  60

 gtg gat ggg ttt gaa aaa aga gca gca gca tct gag agt aac aac tat      240
 Val Asp Gly Phe Glu Lys Arg Ala Ala Ala Ser Glu Ser Asn Asn Tyr
  65                  70                  75                  80

 atg aac cac gtg gcc aaa caa cag tct gag gaa gca ttc cct cag gaa      288
 Met Asn His Val Ala Lys Gln Gln Ser Glu Glu Ala Phe Pro Gln Glu
                  85                  90                  95

 cag cag aaa gca ccc cct gtt gtt ggg ggc ttc aat agc aat gtg gga      336
 Gln Gln Lys Ala Pro Pro Val Val Gly Gly Phe Asn Ser Asn Val Gly
             100                 105                 110

 agt aag gtg tta ggg ctc aaa tat gaa gaa att gac tgt ctc ata aat      384
 Ser Lys Val Leu Gly Leu Lys Tyr Glu Glu Ile Asp Cys Leu Ile Asn
         115                 120                 125

 gat gaa cac aca att aaa ggg aga cga gag ggg aac gaa gtc ttt ctt      432
 Asp Glu His Thr Ile Lys Gly Arg Arg Glu Gly Asn Glu Val Phe Leu
     130                 135                 140

 cca ttc act tgg gtt gag aaa tat ttt gat gtt tat gga aag gtg gtt      480
 Pro Phe Thr Trp Val Glu Lys Tyr Phe Asp Val Tyr Gly Lys Val Val
 145                 150                 155                 160

 cag tat gat ggc tat gat cgg ttt gaa ttc tct cat agc tat tcc aaa      528
 Gln Tyr Asp Gly Tyr Asp Arg Phe Glu Phe Ser His Ser Tyr Ser Lys
                 165                 170                 175

 gtc tat gca cag aga gcc ccc tat cac ccc gat ggt gtg ttt atg tct      576
 Val Tyr Ala Gln Arg Ala Pro Tyr His Pro Asp Gly Val Phe Met Ser
             180                 185                 190

 ttt gaa ggc tac aat gtg gaa gtc cga gac aga gtc aag tgc ata agt      624
 Phe Glu Gly Tyr Asn Val Glu Val Arg Asp Arg Val Lys Cys Ile Ser
         195                 200                 205

 ggg gtt gaa ggt gtg cca tta tct aca caa tgg gga cct caa ggc tat      672
 Gly Val Glu Gly Val Pro Leu Ser Thr Gln Trp Gly Pro Gln Gly Tyr
     210                 215                 220

 ttc tat cca atc cag att gca cag tat gga tta agt cat tac agc aag      720
 Phe Tyr Pro Ile Gln Ile Ala Gln Tyr Gly Leu Ser His Tyr Ser Lys
 225                 230                 235                 240

 aat cta act gag aaa cct cct cac ata gag gta tat gaa aca gca gaa      768
 Asn Leu Thr Glu Lys Pro Pro His Ile Glu Val Tyr Glu Thr Ala Glu
                 245                 250                 255

 gac aga gac aaa aac aag cct aat gac tgg act gtg cca aag ggc tgc      816
 Asp Arg Asp Lys Asn Lys Pro Asn Asp Trp Thr Val Pro Lys Gly Cys
             260                 265                 270

 ttt atg gcg aat gtg gct gat aag tct aga ttc acc aat gtc aaa cag      864
 Phe Met Ala Asn Val Ala Asp Lys Ser Arg Phe Thr Asn Val Lys Gln
         275                 280                 285

 ttt att gca cca gaa acc agt gaa ggt gta tcc ttg caa ctg gga aac      912
 Phe Ile Ala Pro Glu Thr Ser Glu Gly Val Ser Leu Gln Leu Gly Asn
     290                 295                 300

 aca aaa gat ttt att att tca ttt gac ctc aag ttc ttg aca aat gga      960
 Thr Lys Asp Phe Ile Ile Ser Phe Asp Leu Lys Phe Leu Thr Asn Gly
 305                 310                 315                 320

 agt gtg tcc gtg gtt cta gag acc aca gaa aag aat cag ctc ttc act     1008
 Ser Val Ser Val Val Leu Glu Thr Thr Glu Lys Asn Gln Leu Phe Thr
                 325                 330                 335

 ata cat tat gtc tca aat gct cag cta att gct ttt aaa gaa aga gat     1056
 Ile His Tyr Val Ser Asn Ala Gln Leu Ile Ala Phe Lys Glu Arg Asp
             340                 345                 350

 ata tac tat ggc att ggg ccc aga act tca tgg agc aca gtt acc agg     1104
 Ile Tyr Tyr Gly Ile Gly Pro Arg Thr Ser Trp Ser Thr Val Thr Arg
         355                 360                 365

 gac ctg gtc act gac ctc agg aaa gga gtg ggt ctt tca aac aca aaa     1152
 Asp Leu Val Thr Asp Leu Arg Lys Gly Val Gly Leu Ser Asn Thr Lys
     370                 375                 380

 gct gtc aag cca acc aaa ata atg ccc aag aag gtg gtt agg ttg att     1200
 Ala Val Lys Pro Thr Lys Ile Met Pro Lys Lys Val Val Arg Leu Ile
 385                 390                 395                 400

 gca aaa ggt aag gga ttc ctc gac aac att acc atc tct acc aca gcc     1248
 Ala Lys Gly Lys Gly Phe Leu Asp Asn Ile Thr Ile Ser Thr Thr Ala
                 405                 410                 415

 cac atg gct gca ttt ttt gct gct agt gat tgg cta gta agg aac cag     1296
 His Met Ala Ala Phe Phe Ala Ala Ser Asp Trp Leu Val Arg Asn Gln
             420                 425                 430

 gat gag aaa ggt ggc tgg cca att atg gtg acc cgt aag tta ggg gaa     1344
 Asp Glu Lys Gly Gly Trp Pro Ile Met Val Thr Arg Lys Leu Gly Glu
         435                 440                 445

 ggg ttc aag tct tta gag cca gga tgg tat tct gcc atg gcc caa ggg     1392
 Gly Phe Lys Ser Leu Glu Pro Gly Trp Tyr Ser Ala Met Ala Gln Gly
     450                 455                 460

 caa gcc att tct aca tta gtc agg gcc tat ctg tta aca aaa gac cat     1440
 Gln Ala Ile Ser Thr Leu Val Arg Ala Tyr Leu Leu Thr Lys Asp His
 465                 470                 475                 480

 ata ttc ctc aat tca gct tta agg gca aca gcc cct tat aag ttt cta     1488
 Ile Phe Leu Asn Ser Ala Leu Arg Ala Thr Ala Pro Tyr Lys Phe Leu
                 485                 490                 495

 tct gag cag cat gga gtt aaa gct gtg ttt atg aat aaa cat gac tgg     1536
 Ser Glu Gln His Gly Val Lys Ala Val Phe Met Asn Lys His Asp Trp
             500                 505                 510

 tat gaa gaa tat cca acc aca cct agc tct ttt gtt tta aat ggc ttt     1584
 Tyr Glu Glu Tyr Pro Thr Thr Pro Ser Ser Phe Val Leu Asn Gly Phe
         515                 520                 525

 atg tat tct tta att ggg ctg tat gac tta aaa gaa act gca ggg gaa     1632
 Met Tyr Ser Leu Ile Gly Leu Tyr Asp Leu Lys Glu Thr Ala Gly Glu
     530                 535                 540

 aaa ctc gga aaa gaa gca agg tcc ttg tat gag cgt ggc atg gaa tct     1680
 Lys Leu Gly Lys Glu Ala Arg Ser Leu Tyr Glu Arg Gly Met Glu Ser
 545                 550                 555                 560

 ctt aaa gcc atg ctg ccc ttg tat gac act ggc tca gga acc atc tat     1728
 Leu Lys Ala Met Leu Pro Leu Tyr Asp Thr Gly Ser Gly Thr Ile Tyr
                 565                 570                 575

 gac ctc cgt cac ttc atg ctt ggc atc gct cct aac ctg gct cgc tgg     1776
 Asp Leu Arg His Phe Met Leu Gly Ile Ala Pro Asn Leu Ala Arg Trp
             580                 585                 590

 gac tat cat acc acc cac atc aat cag ttg cag cta ctc agt acc att     1824
 Asp Tyr His Thr Thr His Ile Asn Gln Leu Gln Leu Leu Ser Thr Ile
         595                 600                 605

 gat gag tcc cca atc ttc aaa gaa ttt gtc aag agg tgg aaa agc tac     1872
 Asp Glu Ser Pro Ile Phe Lys Glu Phe Val Lys Arg Trp Lys Ser Tyr
     610                 615                 620

 ctt aaa ggc agc agg gca aag cac aac tag a gctcacaacc aaaactgcac     1923
 Leu Lys Gly Ser Arg Ala Lys His Asn 
 625                 630

 ttcagcctct gctgtacaca gaaactacag gctctgtctc aggagagcat aggcacattt   1983

 taaaaggtta tgtactaggt ttttgtggat tctatcaaag tgataagtga tccttaaaac   2043

 cagccttcta aaataattgc attccatggg ttgggtattt agaaatgtag gtggcattta   2103

 gaacacaatg tttaatcaat gggctgaaca aagatgcttc actttgcctt gcccatcacc   2163

 ctatacagtt tcgcagatag tctagtcact ctatgtgaga aagataatgg taagtagttg   2223

 ctactggcca actgtctagc acttacctga aaacttagta tggagctctt ttaaaatgtg   2283

 attatttata tttatgttga aagcggactt taaaaaaaat aatgtgctgt aacacagtaa   2343

 atatgtactt gtagcctgga tagcagactg tgttcaactt tttaaaaaga tgtttccttt   2403

 ctatagatta atttcttggg agcaaatgag tatttgttgc atttgttcaa tttgttgtat   2463

 atggtgaata tttaattatg gttttcttga aacgtgtaaa ttaaaaacac aatcagtgtt   2523

 caggcttcag ttatataatg taagcacaac taaaatgaaa cttgttgact gcacaagaaa   2583

 ttacaaaaat gtttctgttt tgaaacttga tctacaatca gtaaaagttt gataatcagt   2643

 atatcccttc ccaaccccca ttgtgacagt ttctttttgt cactgtctag aattttgtat   2703

 tttatttcag actatacctt ggagttttgt atattttgag agagatattt ttgggacatt   2763

 attttggaaa cttattacaa atctaaattt ggaaaggagc tagtagcttt aaggccacca   2823

 ccatatttta cttttttagg atttttcccc ctttaaataa aaatattaga tcaaatacta   2883

 tatgcaagaa atcatagcaa agtttttttt tcctaccaag atcattcttg atcatcagct   2943

 tcccaaacta gtaagtctgt gcatcattgg gtgttttttt ttaatttaat tttaaattat   3003

 cccagctatt agatagaagg gatgttactg cacttatgtg taatcagatc tttatttagg   3063

 tatacatatc ctcctatacc gcacataaat agatttcaga gcccccatac aatgggcagt   3123

 gtctgctata gggcttcagg cattaaataa aaccgagggt tgttgatttt gctgtgacag   3183

 tacactaaat caatactata tcttatacag tttgaaaata tgatacccta cactttcagg   3243

 ggaccgagtc tgacaaacac aatacattta tctgtgacct atatcaagta cacatttagg   3303

 agccaggtag gttacctgct tacacactat attttaattg aattcaaact atcaagcact   3363

 acttagaaac tggaaaacat atatatgtta gcatcaaagg gggcagaagc aaagaagata   3423

 cagatctgca ctgaagacat tagactggcc atagaaaagt aagcttgaac tcccaattga   3483

 tgtgaccacc tcttcttaat tttgttcaca gtaaaaacac ttttttgagt tattaggctt   3543

 acccctagct tttgaccttt gcatttcata tatgttagat gtctcagcaa gaatatctgg   3603

 tctcccctaa tttttattcc cagtgccgat gttcaaaata aactttctcc agtctgggaa   3663

 ccttttttac ttccccatat ttgttattat ttagaatggt tcatacgtct gctttgtttg   3723

 catactggtc ttcagattat gagactcgat gataacagta tggtactgct tctgtgacaa   3783

 atatcgtgcc ttaacaatgt ggctgtcctt ttccactgaa gaaggaaaga cgttttgatc   3843

 tagaaatagc gttgtgattt ccttgctgtt ggttttacac tgccttccac attgcaacag   3903

 caagttgatt tcttgtgatc ccagaatttt                                    3933




      <210> 56
      <211> 925
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (17)..(925)

      <400> 56
 cagacacaac agctac    atg gaa gca gaa aac ctt aca gaa tta tca aaa      49
                      Met Glu Ala Glu Asn Leu Thr Glu Leu Ser Lys
                        1               5                  10

 ttt ctc ctc ctg gga ctc tca gat gat cct gaa ctg cag ccc gtc ctc       97
 Phe Leu Leu Leu Gly Leu Ser Asp Asp Pro Glu Leu Gln Pro Val Leu
              15                  20                  25

 ttt ggg ctg ttc ctg tcc atg tac ctg gtc acg gtg ctg ggg aac ctg      145
 Phe Gly Leu Phe Leu Ser Met Tyr Leu Val Thr Val Leu Gly Asn Leu
          30                  35                  40

 ctc atc att ctg gcc gtc agc tct gac tcc cac ctc cac acc ccc atg      193
 Leu Ile Ile Leu Ala Val Ser Ser Asp Ser His Leu His Thr Pro Met
      45                  50                  55

 tac ttc ttc ctc tcc aac ctg tgc tgg gct gac atc ggt ttc acc tcg      241
 Tyr Phe Phe Leu Ser Asn Leu Cys Trp Ala Asp Ile Gly Phe Thr Ser
  60                  65                  70                  75

 gcc acg gtt ccc aag ata att gtg gac atg cag tcg cat agc aga gtc      289
 Ala Thr Val Pro Lys Ile Ile Val Asp Met Gln Ser His Ser Arg Val
                  80                  85                  90

 atc tct tat gtg ggc tgc ctg aca cgg atg tct ttt ttg gtc ctt ttt      337
 Ile Ser Tyr Val Gly Cys Leu Thr Arg Met Ser Phe Leu Val Leu Phe
              95                 100                 105

 gca tgt ata gaa gac atg ctt ctg act gtg atg gcc tat gac tgc ttt      385
 Ala Cys Ile Glu Asp Met Leu Leu Thr Val Met Ala Tyr Asp Cys Phe
         110                 115                 120

 gta gcc atc tgt cgc cct cta cac tac cca gtc atc gtg aat gct cac      433
 Val Ala Ile Cys Arg Pro Leu His Tyr Pro Val Ile Val Asn Ala His
     125                 130                 135

 ctc cgt gtc ttc tta gtt ttg gtg tcc ttt ttc ctt agc ctg ttg gat      481
 Leu Arg Val Phe Leu Val Leu Val Ser Phe Phe Leu Ser Leu Leu Asp
 140                 145                 150                 155

 tcc cag ctg cac agg atc ctt ttg tct tac tgt aaa att gtt ccc tcc      529
 Ser Gln Leu His Arg Ile Leu Leu Ser Tyr Cys Lys Ile Val Pro Ser
                 160                 165                 170

 att cta agg att tca aca tca gat ggg aaa tat aaa gcc ttc tcc acc      577
 Ile Leu Arg Ile Ser Thr Ser Asp Gly Lys Tyr Lys Ala Phe Ser Thr
             175                 180                 185

 tgt ggc tct cac ctg gca ctt gtt tgc tta ttt tat gga gca ggc att      625
 Cys Gly Ser His Leu Ala Leu Val Cys Leu Phe Tyr Gly Ala Gly Ile
         190                 195                 200

 ggc gtg tac ctg act tca gct gtg tca cca ccc ccc agg aat ggt gtg      673
 Gly Val Tyr Leu Thr Ser Ala Val Ser Pro Pro Pro Arg Asn Gly Val
     205                 210                 215

 gtg gtg tca gtg atg tac act gtg gtc acc ccc atg ctg aac cct ttc      721
 Val Val Ser Val Met Tyr Thr Val Val Thr Pro Met Leu Asn Pro Phe
 220                 225                 230                 235

 atc tac agc ctg aga aac agg gac att caa agc acc ctg cgg agg ctg      769
 Ile Tyr Ser Leu Arg Asn Arg Asp Ile Gln Ser Thr Leu Arg Arg Leu
                 240                 245                 250

 ctc agc aga aca gtc gaa tct cat gat ctg ttc cat cct ttt tct tgt      817
 Leu Ser Arg Thr Val Glu Ser His Asp Leu Phe His Pro Phe Ser Cys
             255                 260                 265

 gtg gct caa aag aaa ggt gtg ttt ctc atc gcc atg tct atc aaa aaa      865
 Val Ala Gln Lys Lys Gly Val Phe Leu Ile Ala Met Ser Ile Lys Lys
         270                 275                 280

 gag atg atc aat gag gct gtg ggt gtc ttc cgc ctg gcc tgt gtc att      913
 Glu Met Ile Asn Glu Ala Val Gly Val Phe Arg Leu Ala Cys Val Ile
     285                 290                 295

 cat tta cct tga                                                      925
 His Leu Pro 
 300





      <210> 57
      <211> 2110
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (27)..(1514)

      <400> 57
 caggctctgt gttggttgga gcgagc atg tgg gtc tgc agt acc ctg tgg cgg      53
                              Met Trp Val Cys Ser Thr Leu Trp Arg
                                1               5

 gtg cga acc ccc gcc cgg cag tgg cgg ggg ctg ctc cca gct tct ggc      101
 Val Arg Thr Pro Ala Arg Gln Trp Arg Gly Leu Leu Pro Ala Ser Gly
  10                  15                  20                  25

 tgt cac gga cct gcc gcc tcc tcc tac tcc gca tcc gcc gag cct gcc      149
 Cys His Gly Pro Ala Ala Ser Ser Tyr Ser Ala Ser Ala Glu Pro Ala
                  30                  35                  40

 cgg gtc cgg gcg ctt gtc tat ggg cac cac ggg gat cca gcc aag gtc      197
 Arg Val Arg Ala Leu Val Tyr Gly His His Gly Asp Pro Ala Lys Val
              45                  50                  55

 gtc gaa ggc ata acc agg gaa ttg ttc cag agg ttt cct tgg ata ttc      245
 Val Glu Gly Ile Thr Arg Glu Leu Phe Gln Arg Phe Pro Trp Ile Phe
          60                  65                  70

 cta caa ctg ata aca gct gtc att tct tca gca tct act gta ctc aag      293
 Leu Gln Leu Ile Thr Ala Val Ile Ser Ser Ala Ser Thr Val Leu Lys
      75                  80                  85

 aac ctg gag cta gct gct gtg aga gga tca gat gtc cgt gtg aag atg      341
 Asn Leu Glu Leu Ala Ala Val Arg Gly Ser Asp Val Arg Val Lys Met
  90                  95                 100                 105

 ctg gcg gcc cct atc aat cca tct gac ata aat atg atg gtt gga gcg      389
 Leu Ala Ala Pro Ile Asn Pro Ser Asp Ile Asn Met Met Val Gly Ala
                 110                 115                 120

 agc atg tgg gtc tgc agt acc ctg tgg cgg gtg cga acc ccc gcc cgg      437
 Ser Met Trp Val Cys Ser Thr Leu Trp Arg Val Arg Thr Pro Ala Arg
             125                 130                 135

 cag tgg cgg ggg ctg ctc cca gct tct ggc tgt cac gga cct gcc gcc      485
 Gln Trp Arg Gly Leu Leu Pro Ala Ser Gly Cys His Gly Pro Ala Ala
         140                 145                 150

 tcc tcc tac tcc gca tcc gcc gag cct gcc cgg gtc cgg gcg ctt gtc      533
 Ser Ser Tyr Ser Ala Ser Ala Glu Pro Ala Arg Val Arg Ala Leu Val
     155                 160                 165

 tat ggg cac cac ggg gat cca gcc aag gtc gtc gaa ctc aag aac ctg      581
 Tyr Gly His His Gly Asp Pro Ala Lys Val Val Glu Leu Lys Asn Leu
 170                 175                 180                 185

 gag cta gct gct gtg aga gga tca gat gtc cgt gtg aag atg ctg gcg      629
 Glu Leu Ala Ala Val Arg Gly Ser Asp Val Arg Val Lys Met Leu Ala
                 190                 195                 200

 gcc cct atc aat cca tct gac ata aat atg atc caa gga aac tac gga      677
 Ala Pro Ile Asn Pro Ser Asp Ile Asn Met Ile Gln Gly Asn Tyr Gly
             205                 210                 215

 ctc ctt cct gaa ctg cct gct gtt gga ggg aac gaa ggt gtt gca cag      725
 Leu Leu Pro Glu Leu Pro Ala Val Gly Gly Asn Glu Gly Val Ala Gln
         220                 225                 230

 gtg gta gcg gtg ggc agc aat gtg acc ggg ctg aag cca gga gac tgg      773
 Val Val Ala Val Gly Ser Asn Val Thr Gly Leu Lys Pro Gly Asp Trp
     235                 240                 245

 gtg att cca gca aat gct ggt tta gga acc tgg cgg acc gag gct gtg      821
 Val Ile Pro Ala Asn Ala Gly Leu Gly Thr Trp Arg Thr Glu Ala Val
 250                 255                 260                 265

 ttc agc gag gaa gca ctg atc caa gtt ccg agt gac atc cct ctt cag      869
 Phe Ser Glu Glu Ala Leu Ile Gln Val Pro Ser Asp Ile Pro Leu Gln
                 270                 275                 280

 agc gct gcc acc ctg ggt gtc aat ccc tgc aca gcc tac agg atg ttg      917
 Ser Ala Ala Thr Leu Gly Val Asn Pro Cys Thr Ala Tyr Arg Met Leu
             285                 290                 295

 atg gac ttc gag caa ctg cag cca ggg gat tct gtc atc cag aat gca      965
 Met Asp Phe Glu Gln Leu Gln Pro Gly Asp Ser Val Ile Gln Asn Ala
         300                 305                 310

 tcc aac agc gga gtg ggg caa gcg gtc atc cag atc gcc gca gcc ctg     1013
 Ser Asn Ser Gly Val Gly Gln Ala Val Ile Gln Ile Ala Ala Ala Leu
     315                 320                 325

 ggc cta aga acc atc aat gtg gtc cga gac aga cct gat atc cag aag     1061
 Gly Leu Arg Thr Ile Asn Val Val Arg Asp Arg Pro Asp Ile Gln Lys
 330                 335                 340                 345

 ctg agt gac aga ctg aag agt ctg ggg gct gag cat gtc atc aca gaa     1109
 Leu Ser Asp Arg Leu Lys Ser Leu Gly Ala Glu His Val Ile Thr Glu
                 350                 355                 360

 gag gag cta aga agg ccc gaa atg aaa aac ttc ttt aag gac atg ccc     1157
 Glu Glu Leu Arg Arg Pro Glu Met Lys Asn Phe Phe Lys Asp Met Pro
             365                 370                 375

 cag cca cgg ctt gct ctc aac tgt gtt ggt ggg aaa agc tcc aca gag     1205
 Gln Pro Arg Leu Ala Leu Asn Cys Val Gly Gly Lys Ser Ser Thr Glu
         380                 385                 390

 ctg ctg cgg cag tta gcg cgt gga gga acc atg gta acc tat ggg ggg     1253
 Leu Leu Arg Gln Leu Ala Arg Gly Gly Thr Met Val Thr Tyr Gly Gly
     395                 400                 405

 atg gcc aag cag ccc gtc gta gcc tct gtg agc ctg ctc att ttt aag     1301
 Met Ala Lys Gln Pro Val Val Ala Ser Val Ser Leu Leu Ile Phe Lys
 410                 415                 420                 425

 gat ctc aaa ctt cga ggc ttt tgg ttg tcc cag tgg aag aag gat cac     1349
 Asp Leu Lys Leu Arg Gly Phe Trp Leu Ser Gln Trp Lys Lys Asp His
                 430                 435                 440

 agt cca gac cag ttc aag gag ctg atc ctc aca ctg tgc gat ctc atc     1397
 Ser Pro Asp Gln Phe Lys Glu Leu Ile Leu Thr Leu Cys Asp Leu Ile
             445                 450                 455

 cgc cga ggc cag ctc aca gcc cct gcc tgc tcc cag gtc ccg ctg cag     1445
 Arg Arg Gly Gln Leu Thr Ala Pro Ala Cys Ser Gln Val Pro Leu Gln
         460                 465                 470

 gac tac cag tct gcc ttg gaa gcc tcc atg aag ccc ttc ata tct tca     1493
 Asp Tyr Gln Ser Ala Leu Glu Ala Ser Met Lys Pro Phe Ile Ser Ser
     475                 480                 485

 aag cag att ctc acc atg tga tc atcccaaaag agctggagtg acatgggagg     1546
 Lys Gln Ile Leu Thr Met 
 490                 495

 ggaggcggat ctgaggggct gggtgcaggc ccctcagttg gggctcccac cttccccaga   1606

 ctactgttct cctcactgcc tcttcctatt aggaggatgg tgaagccagc cacggttttc   1666

 cccagggcca gccttaaggt tctaataaag tctgaactct cccttccaaa aagtagaagt   1726

 catccctgtc gagaaggacc aacactgtgc actggtcagc tcacagcacc aagaggcccc   1786

 cttcctgctt ttctgtcatg tgttccccca gtaatcattt tctgaccacc ctgaaagcaa   1846

 agcctgggtg ggtactggca gtgcaaaggc cagtaggcca ccatccctgg ccccaagctg   1906

 cacaagccca cagacgaggg tcctgtagaa caaacgcttt gatgtgcttc tcaggtagcc   1966

 tgcggcccag tccagggctt ggggaggatc agctgcatgg aagagtgaat gccaggctga   2026

 ggtcatcagg gccctgagga acttggacgt ggggtcttca ctctcatgga actgcccttc   2086

 taactggaga catagacaat atac                                          2110




      <210> 58
      <211> 3092
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (327)..(3092)

      <400> 58
 ggcgagcgct ctagtgagcg cggacggatg cttaggcagt agtcctggca gcggcagtag     60

 tggtggcagc agaagagagg aagggggagg gccccgaggg ctacacacgc tcacactttc    120

 aagttccctt ggagggagag gaggtggggc tgcagaaaga ggaggccagg agcggtccca    180

 tccgtcccgt cccgtcccgt ctccccctct tcctcttgct ccttgccccc cggctctgcg    240

 agagttgagg gttcaggtgg ccgtacgcgg cagtgagggc aagagggccg ggagagtggg    300

 gagcggaggc aggagtgcgg gggaag atg ccc atc ctg ctg ttc ctc ata gac     353
                              Met Pro Ile Leu Leu Phe Leu Ile Asp
                                1               5

 acg tcc gcc tct atg aac cag cgc act gac ctg ggc acc tct tat ttg      401
 Thr Ser Ala Ser Met Asn Gln Arg Thr Asp Leu Gly Thr Ser Tyr Leu
  10                  15                  20                  25

 gac att gcc aaa ggc gct gtg gag tta ttc ttg aag ctg cgc gcc cgg      449
 Asp Ile Ala Lys Gly Ala Val Glu Leu Phe Leu Lys Leu Arg Ala Arg
                  30                  35                  40

 gac ccg gcc agc cgt gga gac agg tac atg ctg gtc acc tac gac gaa      497
 Asp Pro Ala Ser Arg Gly Asp Arg Tyr Met Leu Val Thr Tyr Asp Glu
              45                  50                  55

 ccc ccg tac tgc atc aag cgt ggc aga gcc agc cgc cgg cct tca aag      545
 Pro Pro Tyr Cys Ile Lys Arg Gly Arg Ala Ser Arg Arg Pro Ser Lys
          60                  65                  70

 act aga caa ccg cct ttg cac tcg ttg gcc tct cac cac ccc cgc gca      593
 Thr Arg Gln Pro Pro Leu His Ser Leu Ala Ser His His Pro Arg Ala
      75                  80                  85

 atc gga aat ctg tcc gcg acg cca gtc tcc cca ccc cca gac ccg gag      641
 Ile Gly Asn Leu Ser Ala Thr Pro Val Ser Pro Pro Pro Asp Pro Glu
  90                  95                 100                 105

 aaa gtc ttt gcg ttt ctg ctc cgg aat tgg cca ggt tca gcc ccg ctc      689
 Lys Val Phe Ala Phe Leu Leu Arg Asn Trp Pro Gly Ser Ala Pro Leu
                 110                 115                 120

 tca gtt acc tta gct act gtt act gtt tca ttg gaa att cca gcg aag      737
 Ser Val Thr Leu Ala Thr Val Thr Val Ser Leu Glu Ile Pro Ala Lys
             125                 130                 135

 caa cga cac gga ggg gga cgt gcc aag ggt gga acc tac ccc ttt agc      785
 Gln Arg His Gly Gly Gly Arg Ala Lys Gly Gly Thr Tyr Pro Phe Ser
         140                 145                 150

 acc aca tgt cag aga aca tac cag aat att caa aag agc ttc agc aac      833
 Thr Thr Cys Gln Arg Thr Tyr Gln Asn Ile Gln Lys Ser Phe Ser Asn
     155                 160                 165

 agg cct gca gag agc atg cca gtt tcc tgt ttg caa acc aac cag tca      881
 Arg Pro Ala Glu Ser Met Pro Val Ser Cys Leu Gln Thr Asn Gln Ser
 170                 175                 180                 185

 gat gag aag gtg gaa atg tgg gtg cag agg gct ggt tgg aag gaa aat      929
 Asp Glu Lys Val Glu Met Trp Val Gln Arg Ala Gly Trp Lys Glu Asn
                 190                 195                 200

 cat gca aca ttc atg agc gaa cta aaa aat ctt cag gct tct gga ctg      977
 His Ala Thr Phe Met Ser Glu Leu Lys Asn Leu Gln Ala Ser Gly Leu
             205                 210                 215

 act act ctc ggt cag gct cta aga tcc tca ttt gat ttg tta aat ctc     1025
 Thr Thr Leu Gly Gln Ala Leu Arg Ser Ser Phe Asp Leu Leu Asn Leu
         220                 225                 230

 aat aga tta ata tct gga ata gac aat tat gga cag ctc cat ctt cct     1073
 Asn Arg Leu Ile Ser Gly Ile Asp Asn Tyr Gly Gln Leu His Leu Pro
     235                 240                 245

 ttg aat tcc cct ctg cct gga agt gaa cta acc aaa gaa cct ttt cgt     1121
 Leu Asn Ser Pro Leu Pro Gly Ser Glu Leu Thr Lys Glu Pro Phe Arg
 250                 255                 260                 265

 tgg gat caa agg tta ttt gcc ctg gtg ttg cgt ttg cct gga gtg gct     1169
 Trp Asp Gln Arg Leu Phe Ala Leu Val Leu Arg Leu Pro Gly Val Ala
                 270                 275                 280

 tct acc gaa cca gag caa cta ggg agc gta cca act gat gaa tct gcc     1217
 Ser Thr Glu Pro Glu Gln Leu Gly Ser Val Pro Thr Asp Glu Ser Ala
             285                 290                 295

 atc aca cag atg tgt gaa gtc aca gga ggt cgc tcc tac tgt gtg aga     1265
 Ile Thr Gln Met Cys Glu Val Thr Gly Gly Arg Ser Tyr Cys Val Arg
         300                 305                 310

 aca caa aga atg ttg aat caa tgt tta gaa tct cta gtt caa aaa gtt     1313
 Thr Gln Arg Met Leu Asn Gln Cys Leu Glu Ser Leu Val Gln Lys Val
     315                 320                 325

 cag agt ggt gta gtt att aat ttt gaa aaa aca gga cca gat cca ctt     1361
 Gln Ser Gly Val Val Ile Asn Phe Glu Lys Thr Gly Pro Asp Pro Leu
 330                 335                 340                 345

 cct att gga gaa gat gga ctt atg gat tca tcc agg cca agc aat tca     1409
 Pro Ile Gly Glu Asp Gly Leu Met Asp Ser Ser Arg Pro Ser Asn Ser
                 350                 355                 360

 ttt gct gct cag cca tgg cat agt tgt cat aaa ctc att tat gta cga     1457
 Phe Ala Ala Gln Pro Trp His Ser Cys His Lys Leu Ile Tyr Val Arg
             365                 370                 375

 cct aac tct aaa act ggt gtt cct gtt gga cat tgg cca att cca gaa     1505
 Pro Asn Ser Lys Thr Gly Val Pro Val Gly His Trp Pro Ile Pro Glu
         380                 385                 390

 tct ttt tgg cca gat cag aat tta cct tca cta cct cca cga aca tct     1553
 Ser Phe Trp Pro Asp Gln Asn Leu Pro Ser Leu Pro Pro Arg Thr Ser
     395                 400                 405

 cat cct gtt gtg agg ttc tcc tgt gta gat tgt gag cca atg gta ata     1601
 His Pro Val Val Arg Phe Ser Cys Val Asp Cys Glu Pro Met Val Ile
 410                 415                 420                 425

 gac aaa ctt cct ttt gac aaa tat gaa ctt gaa cct tcg ccc tta act     1649
 Asp Lys Leu Pro Phe Asp Lys Tyr Glu Leu Glu Pro Ser Pro Leu Thr
                 430                 435                 440

 cag tat atc ttg gaa cga aag tct ccc cat acc tgc tgg cag gta ttt     1697
 Gln Tyr Ile Leu Glu Arg Lys Ser Pro His Thr Cys Trp Gln Val Phe
             445                 450                 455

 gtt act agc agt gga aag tac aat gaa ctt gga tat cca ttt ggt tat     1745
 Val Thr Ser Ser Gly Lys Tyr Asn Glu Leu Gly Tyr Pro Phe Gly Tyr
         460                 465                 470

 tta aaa gcc agt aca act tta act tgt gta aac ctc ttt gtg atg cct     1793
 Leu Lys Ala Ser Thr Thr Leu Thr Cys Val Asn Leu Phe Val Met Pro
     475                 480                 485

 tac aac tac cca gtt tta ctt cct ctt tta gat gac ttg ttt aaa gtt     1841
 Tyr Asn Tyr Pro Val Leu Leu Pro Leu Leu Asp Asp Leu Phe Lys Val
 490                 495                 500                 505

 cac aag ctt aag cca aat ctg aag tgg cga cag gct ttt gac agc tac     1889
 His Lys Leu Lys Pro Asn Leu Lys Trp Arg Gln Ala Phe Asp Ser Tyr
                 510                 515                 520

 tta aaa act ctg cct cca tac tac cta tta acc aaa cta gag tca gaa     1937
 Leu Lys Thr Leu Pro Pro Tyr Tyr Leu Leu Thr Lys Leu Glu Ser Glu
             525                 530                 535

 cga ata cta gca tca gtg ggg aag aaa cct ccc cag gaa att gga att     1985
 Arg Ile Leu Ala Ser Val Gly Lys Lys Pro Pro Gln Glu Ile Gly Ile
         540                 545                 550

 aaa gtg aaa aat cat tct gga ggt ggc atg tcc ttg act cac aat aaa     2033
 Lys Val Lys Asn His Ser Gly Gly Gly Met Ser Leu Thr His Asn Lys
     555                 560                 565

 aat ttt aga aaa cta ttg aaa gaa atc aca ggg gaa act gca ctt aga     2081
 Asn Phe Arg Lys Leu Leu Lys Glu Ile Thr Gly Glu Thr Ala Leu Arg
 570                 575                 580                 585

 ctg aca gaa ttg aac acc aaa gaa ttt gct ggc ttc caa att ggg ctc     2129
 Leu Thr Glu Leu Asn Thr Lys Glu Phe Ala Gly Phe Gln Ile Gly Leu
                 590                 595                 600

 tta aac aag gat ttg aaa cct cag aca tac aga aat gct tat gat att     2177
 Leu Asn Lys Asp Leu Lys Pro Gln Thr Tyr Arg Asn Ala Tyr Asp Ile
             605                 610                 615

 ccc cgt aga ggt ctt tta gac cag ctg acc aga atg aga tcc aat ctg     2225
 Pro Arg Arg Gly Leu Leu Asp Gln Leu Thr Arg Met Arg Ser Asn Leu
         620                 625                 630

 ctg aaa acg cac aag ttt att gtt gga caa gat gaa gat tcc ctt cat     2273
 Leu Lys Thr His Lys Phe Ile Val Gly Gln Asp Glu Asp Ser Leu His
     635                 640                 645

 agt gtt cca gtt gca caa atg ggt aac tat cag gaa tat ctg aag aca     2321
 Ser Val Pro Val Ala Gln Met Gly Asn Tyr Gln Glu Tyr Leu Lys Thr
 650                 655                 660                 665

 ttg gct tct cca ctg cga gag att gat cca gac caa ccc aaa aga ctg     2369
 Leu Ala Ser Pro Leu Arg Glu Ile Asp Pro Asp Gln Pro Lys Arg Leu
                 670                 675                 680

 cat act ttt ggc aat ccg ttt aaa caa gat aag aag gga atg atg att     2417
 His Thr Phe Gly Asn Pro Phe Lys Gln Asp Lys Lys Gly Met Met Ile
             685                 690                 695

 gat gaa gca gat gag ttt gta gca ggg cca caa aac aaa gtg aaa cgt     2465
 Asp Glu Ala Asp Glu Phe Val Ala Gly Pro Gln Asn Lys Val Lys Arg
         700                 705                 710

 cca ggg gaa ccc aac agt cct atg tca tct aag aga agg cgg agt atg     2513
 Pro Gly Glu Pro Asn Ser Pro Met Ser Ser Lys Arg Arg Arg Ser Met
     715                 720                 725

 tcc ctg ctg ttg agg aaa cca caa aca cca cct act gta act aac cat     2561
 Ser Leu Leu Leu Arg Lys Pro Gln Thr Pro Pro Thr Val Thr Asn His
 730                 735                 740                 745

 ctc aac ctc ttc att tgg ttt cca gat gct act atc att cac gat ggc     2609
 Leu Asn Leu Phe Ile Trp Phe Pro Asp Ala Thr Ile Ile His Asp Gly
                 750                 755                 760

 cat gag gag aag atg gaa aat ggt cag atc aca cct gat ggc ttc ctg     2657
 His Glu Glu Lys Met Glu Asn Gly Gln Ile Thr Pro Asp Gly Phe Leu
             765                 770                 775

 tca aaa tct gct cca tca gag ctt ata aat atg aca gga gat ctt atg     2705
 Ser Lys Ser Ala Pro Ser Glu Leu Ile Asn Met Thr Gly Asp Leu Met
         780                 785                 790

 cca ccc aac caa gtg gat tct ctg tct gac gac ttc aca agt ctc agc     2753
 Pro Pro Asn Gln Val Asp Ser Leu Ser Asp Asp Phe Thr Ser Leu Ser
     795                 800                 805

 aaa gat ggg ctg att caa aaa cct ggt agt aac gca ttt gta gga gga     2801
 Lys Asp Gly Leu Ile Gln Lys Pro Gly Ser Asn Ala Phe Val Gly Gly
 810                 815                 820                 825

 gcc aaa aac tgc agt ctc tcc gta gat gac caa aaa gac cca gta gca     2849
 Ala Lys Asn Cys Ser Leu Ser Val Asp Asp Gln Lys Asp Pro Val Ala
                 830                 835                 840

 tct act ttg gga gct atg cca aat aca tta caa atc act cct gct atg     2897
 Ser Thr Leu Gly Ala Met Pro Asn Thr Leu Gln Ile Thr Pro Ala Met
             845                 850                 855

 gca caa gga atc aat gct gat ata aaa cat caa tta atg aag gaa gtt     2945
 Ala Gln Gly Ile Asn Ala Asp Ile Lys His Gln Leu Met Lys Glu Val
         860                 865                 870

 cga aag ttt ggt cga aaa tat gaa aga att ttc att ttg ctt gaa gaa     2993
 Arg Lys Phe Gly Arg Lys Tyr Glu Arg Ile Phe Ile Leu Leu Glu Glu
     875                 880                 885

 gtg caa gga cct ctg gag atg aag aaa cag ttt gtt gaa ttt acc atc     3041
 Val Gln Gly Pro Leu Glu Met Lys Lys Gln Phe Val Glu Phe Thr Ile
 890                 895                 900                 905

 aag gaa gcc gca aga gca gta ggg ccc agt gca gga aaa aga gag gaa     3089
 Lys Glu Ala Ala Arg Ala Val Gly Pro Ser Ala Gly Lys Arg Glu Glu
                 910                 915                 920

 tag                                                                 3092
 






      <210> 59
      <211> 2232
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (658)..(2019)

      <400> 59
 ctcctgagtt gcgaggagtc gccgctgccg ccactgcctg agttttatga ggtttattgc     60

 tcgccgccgt ctcccgcgtg ctgactggcg cttctcaaaa tccgccaagc agagtgctgg    120

 tagcatcccg taattttgca aatgatgcta catttgaaaa taagaaatgt gaccttcacc    180

 ggctggaaga aggccctcct gtcacaacag tgctcaccag gtaggatggg ctcacatact    240

 acaggatgat gcagactgca cgccgaatgg agttgaaagc agatctgctg gggcacctga    300

 aggagacttg ggggcacccg cgtcgtgcct cctgggttgt gaggagtcgc cgctgccgcc    360

 actgcctgtg cttcatgagg aagatgctcg ccgccgtctc ccgcgtgctg tctggcgctt    420

 ctcagaagcc ggcaagcaga gtgctggtag catcccgtaa ttttgcaaat gatgctacat    480

 ttgaaattaa gaaatgtgac cttcaccggc tggaagaagg ccctcctgtc acaacagtgc    540

 tcaccaggga ggatgggctc aaatactaca ggatgatgca gactgtacgc cgaatggagt    600

 tgaaagcaga tcagctgtat aaacagaaaa ttattcgtgg tttctgtcac ttgtgtg       657                                                                 
 atg gtc agg aag ctt gct gtg tgg gcc tgg agg ccg gca tca acc cca      705
 Met Val Arg Lys Leu Ala Val Trp Ala Trp Arg Pro Ala Ser Thr Pro
   1               5                  10                  15

 cag act cac tct ctt aaa acc agg cag gca agc aga gtg ctg gta gca      753
 Gln Thr His Ser Leu Lys Thr Arg Gln Ala Ser Arg Val Leu Val Ala
              20                  25                  30

 tcc cgg ctg ggg cac ctg aag gag act tgg ggg cac ccg cgt cgt gcc      801
 Ser Arg Leu Gly His Leu Lys Glu Thr Trp Gly His Pro Arg Arg Ala
          35                  40                  45

 tcc tgg gtt gtg agg agt cgc cgc tgc cgc cac tgc ctg tgc ttc atg      849
 Ser Trp Val Val Arg Ser Arg Arg Cys Arg His Cys Leu Cys Phe Met
      50                  55                  60

 agg aag atg ctc gcc gcc gtc tcc cgc gtg ctg tct ggc gct tct cag      897
 Arg Lys Met Leu Ala Ala Val Ser Arg Val Leu Ser Gly Ala Ser Gln
  65                  70                  75                  80

 aag ccg gca agc aga gtg ctg gta gca tcc cgt aat ttt gca aat gat      945
 Lys Pro Ala Ser Arg Val Leu Val Ala Ser Arg Asn Phe Ala Asn Asp
                  85                  90                  95

 gct aca ttt gaa att aag aaa tgt gac ctt cac cgg ctg gaa gaa ggc      993
 Ala Thr Phe Glu Ile Lys Lys Cys Asp Leu His Arg Leu Glu Glu Gly
             100                 105                 110

 cct cct gtc aca aca gtg ctc acc agg gag gat ggg ctc aaa tac tac     1041
 Pro Pro Val Thr Thr Val Leu Thr Arg Glu Asp Gly Leu Lys Tyr Tyr
         115                 120                 125

 agg atg atg cag act gta cgc cga atg gag ttg aaa gca gat cag ctg     1089
 Arg Met Met Gln Thr Val Arg Arg Met Glu Leu Lys Ala Asp Gln Leu
     130                 135                 140

 tat aaa cag aaa att att cgt ggt ttc tgt cac ttg tgt gat ggt cag     1137
 Tyr Lys Gln Lys Ile Ile Arg Gly Phe Cys His Leu Cys Asp Gly Gln
 145                 150                 155                 160

 gaa gct tgc tgt gtg ggc ctg gag gcc ggc atc aac ccc aca gac cat     1185
 Glu Ala Cys Cys Val Gly Leu Glu Ala Gly Ile Asn Pro Thr Asp His
                 165                 170                 175

 ctc atc aca gcc tac cgg gct cac ggc ttt act ttc acc cgg ggc ctt     1233
 Leu Ile Thr Ala Tyr Arg Ala His Gly Phe Thr Phe Thr Arg Gly Leu
             180                 185                 190

 tcc gtc cga gaa att ctc gca gag ctt aca gga cga aaa gga ggt tgt     1281
 Ser Val Arg Glu Ile Leu Ala Glu Leu Thr Gly Arg Lys Gly Gly Cys
         195                 200                 205

 gct aaa ggg aaa gga gga tcg atg cac atg tat gcc aag aac ttc tac     1329
 Ala Lys Gly Lys Gly Gly Ser Met His Met Tyr Ala Lys Asn Phe Tyr
     210                 215                 220

 ggg ggc aat ggc atc gtg gga gcg cag gtg ccc ctg ggc gct ggg att     1377
 Gly Gly Asn Gly Ile Val Gly Ala Gln Val Pro Leu Gly Ala Gly Ile
 225                 230                 235                 240

 gct cta gcc tgt aag tat aat gga aaa gat gag gtc tgc ctg act tta     1425
 Ala Leu Ala Cys Lys Tyr Asn Gly Lys Asp Glu Val Cys Leu Thr Leu
                 245                 250                 255

 tat ggc gat ggt gct gct aac cag ggc cag ata ttc gaa gct tac aac     1473
 Tyr Gly Asp Gly Ala Ala Asn Gln Gly Gln Ile Phe Glu Ala Tyr Asn
             260                 265                 270

 atg gca gct ttg tgg aaa tta cct tgt att ttc atc tgt gag aat aat     1521
 Met Ala Ala Leu Trp Lys Leu Pro Cys Ile Phe Ile Cys Glu Asn Asn
         275                 280                 285

 cgc tat gga atg gga acg tct gtt gag aga gcg gca gcc agc act gat     1569
 Arg Tyr Gly Met Gly Thr Ser Val Glu Arg Ala Ala Ala Ser Thr Asp
     290                 295                 300

 tac tac aag aga ggc gat ttc att cct ggg ctg aga gtg gat gga atg     1617
 Tyr Tyr Lys Arg Gly Asp Phe Ile Pro Gly Leu Arg Val Asp Gly Met
 305                 310                 315                 320

 gat atc ctg tgc gtc cga gag gca aca agg ttt gct gct gcc tat tgt     1665
 Asp Ile Leu Cys Val Arg Glu Ala Thr Arg Phe Ala Ala Ala Tyr Cys
                 325                 330                 335

 aga tct ggg aag ggg ccc atc ctg atg gag ctg cag act tac cgt tac     1713
 Arg Ser Gly Lys Gly Pro Ile Leu Met Glu Leu Gln Thr Tyr Arg Tyr
             340                 345                 350

 cac gga cac agt atg agt gac cct gga gtc agt tac cgt aca cga gaa     1761
 His Gly His Ser Met Ser Asp Pro Gly Val Ser Tyr Arg Thr Arg Glu
         355                 360                 365

 gaa att cag gaa gta aga agt aag agt gac cct att atg ctt ctc aag     1809
 Glu Ile Gln Glu Val Arg Ser Lys Ser Asp Pro Ile Met Leu Leu Lys
     370                 375                 380

 gac agg atg gtg aac agc aat ctt gcc agt gtg gaa gaa cta aag gaa     1857
 Asp Arg Met Val Asn Ser Asn Leu Ala Ser Val Glu Glu Leu Lys Glu
 385                 390                 395                 400

 att gat gtg gaa gtg agg aag gag att gag gat gct gcc cag ttt gcc     1905
 Ile Asp Val Glu Val Arg Lys Glu Ile Glu Asp Ala Ala Gln Phe Ala
                 405                 410                 415

 acg gcc gat cct gag cca cct ttg gaa gag ctg ggc tac cac atc tac     1953
 Thr Ala Asp Pro Glu Pro Pro Leu Glu Glu Leu Gly Tyr His Ile Tyr
             420                 425                 430

 tcc agc gac cca cct ttt gaa gtt cgt ggt gcc aat cag tgg atc aag     2001
 Ser Ser Asp Pro Pro Phe Glu Val Arg Gly Ala Asn Gln Trp Ile Lys
         435                 440                 445

 ttt aag tca gtc agt taa ggggag gagaaggaga ggttatacct tcagggggct     2055
 Phe Lys Ser Val Ser 
     450

 accagacagt gttctcaact tggttaagga ggaagaaaac ccagtcaatg aaattcaatg   2115

 aaattcttgg aaacttccat taagtgtgta gattgagcag gtagtaattg catgcagttt   2175

 gtacattagt gcattaaaag atgaattatt gagtgcttaa aaaaaaaaaa aaaaaag      2232




      <210> 60
      <211> 888
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (169)..(711)

      <400> 60
 atgaaaatct cagaagctgt gcggatggct gtctgcccgg aagcctgccc cctctgctca     60

 gcacagctag cttcccctgc tctgcaggaa gctggacagg atgggggaaa gcctgagtta    120

 gctgagctag tcctggagta cagggagacc agcaacctga gcggggag atg ctt agt     177
                                                      Met Leu Ser
                                                        1

 cct gac ctg cct gac tct gcc tgg aac acc agg ctc ctc tgc cgt gtc      225
 Pro Asp Leu Pro Asp Ser Ala Trp Asn Thr Arg Leu Leu Cys Arg Val
       5                  10                  15

 atg ctt tgt ctc ctg gga gca ggt tca gtg gct gct gga gtc atc cag      273
 Met Leu Cys Leu Leu Gly Ala Gly Ser Val Ala Ala Gly Val Ile Gln
  20                  25                  30                  35

 tcc cca aga cat ctg atc aaa gaa aag agg gaa aca gcc act ctg aaa      321
 Ser Pro Arg His Leu Ile Lys Glu Lys Arg Glu Thr Ala Thr Leu Lys
                  40                  45                  50

 tgc tat cct atc cct aga cac gac act gtc tac tgg tac cag cag ggt      369
 Cys Tyr Pro Ile Pro Arg His Asp Thr Val Tyr Trp Tyr Gln Gln Gly
              55                  60                  65

 cca ggt cag gac ccc cag ttc ctc att tcg ttt tat gaa aag atg cag      417
 Pro Gly Gln Asp Pro Gln Phe Leu Ile Ser Phe Tyr Glu Lys Met Gln
          70                  75                  80

 agc gat aaa gga agc atc cct gat cga ttc tca gct caa cag ttc agt      465
 Ser Asp Lys Gly Ser Ile Pro Asp Arg Phe Ser Ala Gln Gln Phe Ser
      85                  90                  95

 gac tat cat tct gaa ctg aac atg agc tcc ttg gag ctg ggg gac tca      513
 Asp Tyr His Ser Glu Leu Asn Met Ser Ser Leu Glu Leu Gly Asp Ser
 100                 105                 110                 115

 gcc ctg tac ttc tgt gcc agc agt cgc gga gag ctg cgg tac ggg atc      561
 Ala Leu Tyr Phe Cys Ala Ser Ser Arg Gly Glu Leu Arg Tyr Gly Ile
                 120                 125                 130

 tac gag cag tac ttc ggg ccg ggc acc agg ctc acg gtc aca gag gac      609
 Tyr Glu Gln Tyr Phe Gly Pro Gly Thr Arg Leu Thr Val Thr Glu Asp
             135                 140                 145

 ctg aaa aac gtg ttc cca ccc gag gtc gct gtg ttt gag cca tca gaa      657
 Leu Lys Asn Val Phe Pro Pro Glu Val Ala Val Phe Glu Pro Ser Glu
         150                 155                 160

 gca gag atc tcc cac acc caa aag gcc aca ctg ttg tgc ctg gtc aca      705
 Ala Glu Ile Ser His Thr Gln Lys Ala Thr Leu Leu Cys Leu Val Thr
     165                 170                 175

 ggc taa ccgccggagc accggggctg tactgcccct gactgggaac gagcccaccg       761
 Gly 
 180

 cgccgccgcc cccccccgca cccccaccga caggtcggcc tccggactcc ccacccccct    821

 gaccgccccc tgggggttgg ggaaggtggg ggagaggggg ggaatatttt ttctcccccc    881

 ccccccc                                                              888




      <210> 61
      <211> 813
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (1)..(813)

      <400> 61
  atg gcc acc ccg cca ttc cgg ctg ata agg aag atg ttt tcc ttc aag      48
  Met Ala Thr Pro Pro Phe Arg Leu Ile Arg Lys Met Phe Ser Phe Lys
    1               5                  10                  15

 gtg agc aga tgg atg ggg ctt gcc tgc ttc cgg tcc ctg gcg gca tcc       96
 Val Ser Arg Trp Met Gly Leu Ala Cys Phe Arg Ser Leu Ala Ala Ser
              20                  25                  30

 tct ccc agt att cgc cag aag aaa cta atg cac aag ctg cag gag gaa      144
 Ser Pro Ser Ile Arg Gln Lys Lys Leu Met His Lys Leu Gln Glu Glu
          35                  40                  45

 aag gct ttt cgc gaa gag atg aaa att ttt cgt gaa aaa ata gag gac      192
 Lys Ala Phe Arg Glu Glu Met Lys Ile Phe Arg Glu Lys Ile Glu Asp
      50                  55                  60

 ttc agg gaa gag atg tgg act ttc cga ggc aag atc cat gct ttc cgg      240
 Phe Arg Glu Glu Met Trp Thr Phe Arg Gly Lys Ile His Ala Phe Arg
  65                  70                  75                  80

 ggc cag atc ctg ggt ttt tgg gaa gag gag aga cct ttc tgg gaa gag      288
 Gly Gln Ile Leu Gly Phe Trp Glu Glu Glu Arg Pro Phe Trp Glu Glu
                  85                  90                  95

 gag aaa acc ttc tgg aaa gag gaa aaa tcc ttc tgg gaa atg gaa aag      336
 Glu Lys Thr Phe Trp Lys Glu Glu Lys Ser Phe Trp Glu Met Glu Lys
             100                 105                 110

 tct ttc agg gag gaa gag aaa act ttc tgg aaa aag tac cgc act ttc      384
 Ser Phe Arg Glu Glu Glu Lys Thr Phe Trp Lys Lys Tyr Arg Thr Phe
         115                 120                 125

 tgg aag gag gat aag gcc ttc tgg aaa gag gac aat gcc tta tgg gaa      432
 Trp Lys Glu Asp Lys Ala Phe Trp Lys Glu Asp Asn Ala Leu Trp Glu
     130                 135                 140

 aga gac cgg aac ctt ctt cag gag gac aag gcc ctg tgg gag gaa gaa      480
 Arg Asp Arg Asn Leu Leu Gln Glu Asp Lys Ala Leu Trp Glu Glu Glu
 145                 150                 155                 160

 aag gcc ctg tgg gta gag gaa aga gcc ctc ctt gag ggg gag aaa gcc      528
 Lys Ala Leu Trp Val Glu Glu Arg Ala Leu Leu Glu Gly Glu Lys Ala
                 165                 170                 175

 ctg tgg gaa gat aaa acg tcc ctc tgg gag gaa gag aat gcc ctc tgg      576
 Leu Trp Glu Asp Lys Thr Ser Leu Trp Glu Glu Glu Asn Ala Leu Trp
             180                 185                 190

 gag gaa gag agg gcc ttc tgg atg gag aac aat ggc cac att gcc gga      624
 Glu Glu Glu Arg Ala Phe Trp Met Glu Asn Asn Gly His Ile Ala Gly
         195                 200                 205

 gag cag atg ctc gaa gat ggg ccc cac aac gcc aac aga ggg cag cgc      672
 Glu Gln Met Leu Glu Asp Gly Pro His Asn Ala Asn Arg Gly Gln Arg
     210                 215                 220

 ttg ctg gcc ttc tcc cga ggc agg cgt agc cag cat gca ggt gca ggg      720
 Leu Leu Ala Phe Ser Arg Gly Arg Arg Ser Gln His Ala Gly Ala Gly
 225                 230                 235                 240

 ccc tgt ggt cca gac tcc cct ggg ttg gga ttc aag tcc agg gtg agc      768
 Pro Cys Gly Pro Asp Ser Pro Gly Leu Gly Phe Lys Ser Arg Val Ser
                 245                 250                 255

 cca tgt gct gga gaa aat aca cac tca ttg gtc tcc ttg ctt tga          813
 Pro Cys Ala Gly Glu Asn Thr His Ser Leu Val Ser Leu Leu 
             260                 265                 270





      <210> 62
      <211> 2752
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (1)..(1755)

      <400> 62
  atg gtg atg agt ttc cgg gtg tct gag ctc cag gtg ctt ctt ggc ttt      48
  Met Val Met Ser Phe Arg Val Ser Glu Leu Gln Val Leu Leu Gly Phe
    1               5                  10                  15

 gct ggc cgg aac aag agt gga cgg aag cac gag ctc ctg gcc aag gct       96
 Ala Gly Arg Asn Lys Ser Gly Arg Lys His Glu Leu Leu Ala Lys Ala
              20                  25                  30

 ctg cac ctc ctg aag tcc agc tgt gcc cct agt gtc cag atg aag atc      144
 Leu His Leu Leu Lys Ser Ser Cys Ala Pro Ser Val Gln Met Lys Ile
          35                  40                  45

 aaa gag ctt tac cga cga cgc ttt ccc cgg aag acc ctg ggg ccc tct      192
 Lys Glu Leu Tyr Arg Arg Arg Phe Pro Arg Lys Thr Leu Gly Pro Ser
      50                  55                  60

 gat ctc tcc ctt ctc tct ttg ccc cct ggc acc tct cct cct gtg cac      240
 Asp Leu Ser Leu Leu Ser Leu Pro Pro Gly Thr Ser Pro Pro Val His
  65                  70                  75                  80

 cct gat gtc acc atg aaa cca ttg ccc ttc tat gaa gtc tat ggg gag      288
 Pro Asp Val Thr Met Lys Pro Leu Pro Phe Tyr Glu Val Tyr Gly Glu
                  85                  90                  95

 ctc atc cgg ccc acc acc ctt gca tcc act tct agc cag cgg ttt gag      336
 Leu Ile Arg Pro Thr Thr Leu Ala Ser Thr Ser Ser Gln Arg Phe Glu
             100                 105                 110

 gaa gcg cac ttt acc ttt gcc ctc aca ccc cag caa gtg cag cag att      384
 Glu Ala His Phe Thr Phe Ala Leu Thr Pro Gln Gln Val Gln Gln Ile
         115                 120                 125

 ctt aca tcc aga gag gtt ctg cca gga gcc aaa tgt gat tat acc ata      432
 Leu Thr Ser Arg Glu Val Leu Pro Gly Ala Lys Cys Asp Tyr Thr Ile
     130                 135                 140

 cag gtg cag cta agg ttc tgt ctc tgt gag acc agc tgc ccc cag gaa      480
 Gln Val Gln Leu Arg Phe Cys Leu Cys Glu Thr Ser Cys Pro Gln Glu
 145                 150                 155                 160

 gat tat ttt ccc ccc aac ctc ttt gtc aag gtc aat ggg aaa ctg tgc      528
 Asp Tyr Phe Pro Pro Asn Leu Phe Val Lys Val Asn Gly Lys Leu Cys
                 165                 170                 175

 ccc ctg ccg ggt tac ctt ccc cca acc aag aat ggg gcc gag ccc aag      576
 Pro Leu Pro Gly Tyr Leu Pro Pro Thr Lys Asn Gly Ala Glu Pro Lys
             180                 185                 190

 agg ccc agc cgc ccc atc aac atc aca ccc ctg gct cga ctc tca gcc      624
 Arg Pro Ser Arg Pro Ile Asn Ile Thr Pro Leu Ala Arg Leu Ser Ala
         195                 200                 205

 act gtt ccc aac acc att gtg gtc aat tgg tca tct gag ttc gga cgg      672
 Thr Val Pro Asn Thr Ile Val Val Asn Trp Ser Ser Glu Phe Gly Arg
     210                 215                 220

 aat tac tcc ttg tct gtg tac ctg gtg agg cag ttg act gca gga acc      720
 Asn Tyr Ser Leu Ser Val Tyr Leu Val Arg Gln Leu Thr Ala Gly Thr
 225                 230                 235                 240

 ctt cta caa aaa ctc aga gca aag ggt atc cgg aac cca gac cac tcg      768
 Leu Leu Gln Lys Leu Arg Ala Lys Gly Ile Arg Asn Pro Asp His Ser
                 245                 250                 255

 cgg gca ctg atc aag gag aaa ttg act gct gac cct gac agt gag gtg      816
 Arg Ala Leu Ile Lys Glu Lys Leu Thr Ala Asp Pro Asp Ser Glu Val
             260                 265                 270

 gcc act aca agt ctc cgg gtg tca ctc atg tgc ccg cta ggg aag atg      864
 Ala Thr Thr Ser Leu Arg Val Ser Leu Met Cys Pro Leu Gly Lys Met
         275                 280                 285

 cgc ctg act gtc cct tgt cgt gcc ctc acc tgc gcc cac ctg cag agc      912
 Arg Leu Thr Val Pro Cys Arg Ala Leu Thr Cys Ala His Leu Gln Ser
     290                 295                 300

 ttc gat gct gcc ctt tat cta cag atg aat gag aag aag cct aca tgg      960
 Phe Asp Ala Ala Leu Tyr Leu Gln Met Asn Glu Lys Lys Pro Thr Trp
 305                 310                 315                 320

 aca tgt cct gtg tgt gac aag aag gct ccc tat gaa tct ctt atc att     1008
 Thr Cys Pro Val Cys Asp Lys Lys Ala Pro Tyr Glu Ser Leu Ile Ile
                 325                 330                 335

 gat ggt tta ttt atg gag att ctt agt tcc tgt tca gat tgt gat gag     1056
 Asp Gly Leu Phe Met Glu Ile Leu Ser Ser Cys Ser Asp Cys Asp Glu
             340                 345                 350

 atc caa ttc atg gaa gat gga tcc tgg tgc cca atg aaa ccc aag aag     1104
 Ile Gln Phe Met Glu Asp Gly Ser Trp Cys Pro Met Lys Pro Lys Lys
         355                 360                 365

 gag gca tct gag gtt tgc ccc ccg cca ggg tat ggg ctg gat ggc ctc     1152
 Glu Ala Ser Glu Val Cys Pro Pro Pro Gly Tyr Gly Leu Asp Gly Leu
     370                 375                 380

 cag tac agc cca gtc cag ggg gga gat cca tca gag aat aag aag aag     1200
 Gln Tyr Ser Pro Val Gln Gly Gly Asp Pro Ser Glu Asn Lys Lys Lys
 385                 390                 395                 400

 gtc gaa gtt att gac ttg aca ata gaa agc tca tca gat gag gag gat     1248
 Val Glu Val Ile Asp Leu Thr Ile Glu Ser Ser Ser Asp Glu Glu Asp
                 405                 410                 415

 ctg ccc cct acc aag aag cac tgt tct gtc acc tca gct gcc atc ccg     1296
 Leu Pro Pro Thr Lys Lys His Cys Ser Val Thr Ser Ala Ala Ile Pro
             420                 425                 430

 gcc cta cct gga agc aaa gga gtc ctg aca tct ggc cac cag cca tcc     1344
 Ala Leu Pro Gly Ser Lys Gly Val Leu Thr Ser Gly His Gln Pro Ser
         435                 440                 445

 tcg gtg cta agg agc cct gct atg ggc acg ttg ggt ggg gat ttc ctg     1392
 Ser Val Leu Arg Ser Pro Ala Met Gly Thr Leu Gly Gly Asp Phe Leu
     450                 455                 460

 tcc agt ctc cca cta cat gag tac cca cct gcc ttc cca ctg gga gcc     1440
 Ser Ser Leu Pro Leu His Glu Tyr Pro Pro Ala Phe Pro Leu Gly Ala
 465                 470                 475                 480

 gac atc caa ggt tta gat tta ttt tca ttt ctt cag aca gag agt cag     1488
 Asp Ile Gln Gly Leu Asp Leu Phe Ser Phe Leu Gln Thr Glu Ser Gln
                 485                 490                 495

 cac tat ggc ccc tct gtc atc acc tca cta gat gaa cag gat gcc ctt     1536
 His Tyr Gly Pro Ser Val Ile Thr Ser Leu Asp Glu Gln Asp Ala Leu
             500                 505                 510

 ggc cac ttc ttc cag tac cga ggg acc cct tct cac ttt ctg ggc cca     1584
 Gly His Phe Phe Gln Tyr Arg Gly Thr Pro Ser His Phe Leu Gly Pro
         515                 520                 525

 ctg gcc ccc acg ctg ggg agc tcc cac tgc agc gcc act ccg gcg ccc     1632
 Leu Ala Pro Thr Leu Gly Ser Ser His Cys Ser Ala Thr Pro Ala Pro
     530                 535                 540

 cct cct ggc cgt gtc agc agc att gtg gcc cct ggg ggg gcc ttg agg     1680
 Pro Pro Gly Arg Val Ser Ser Ile Val Ala Pro Gly Gly Ala Leu Arg
 545                 550                 555                 560

 gag ggg cat gga gga ccc ctg ccc tca ggt ccc tct ttg act ggc tgt     1728
 Glu Gly His Gly Gly Pro Leu Pro Ser Gly Pro Ser Leu Thr Gly Cys
                 565                 570                 575

 cgg tca gac atc att tcc ctg gac tga gttcc ctggattatg gaaacttcgc     1780
 Arg Ser Asp Ile Ile Ser Leu Asp 
             580

 tgtcccccaa cactgagcaa gtatgctgtg gagtcccaac cccagctact ctgatccctc   1840

 tgggggctct ggccaagggc cagacagacc ttcacagatg cctacttttg gcctcatctc   1900

 tgcctgacaa ggccagcacc caaagggtta atatttaacc tctttttaag gacactgggg   1960

 tctgtttctg gaaatgttct ttagatggtg gcacattcct ttgggtatgt taacctaggc   2020

 agtgggaggc aaatgggatg gtatgtgagc taggagaagg gctgaaccct cagccttgac   2080

 tatgtctaga gcctcttggg gaaggggcac ctctcttgaa ccccaaatgc tctctcttct   2140

 tattacccaa acccatggct ctatttcttc ttcacatcca ttgtctcttc atgtctattc   2200

 cattcccttc ggccaaacag acaggtggaa aaactgagac aggcagtttc agagatggac   2260

 agagaacttt attttggatt gtggatgtgg acttttttgt acataaataa gaaaaaccaa   2320

 aatactccaa agatgacttc ccctgcctcc tactccagta tgacagagga ggatgtaagg   2380

 ccttagccat gatctgcagg ggtctgggag tcaggcccgg cctattgctt gggtctctct   2440

 ctatttatat atctaagttc acagtgtttc ttattccccc ctaagcttct agaggctcat   2500

 ggccctgtag ttaggcctgg ctcattctgc acctttccag ggaggtggaa ggaccctgtg   2560

 ccctccttcc caatcttctt tttcaggctc gccaaggcct aggacctatg ttgtaatttt   2620

 actttttatt tctaaagttg tagtgaagct ctcacccata ataaaggttg tgaatgttca   2680

 aaaaaaaaaa aaaaaaaaaa aaagatcttt aactacgccg cccaagctta tcccctctac   2740

 tgagcgttaa tt                                                       2752




      <210> 63
      <211> 1129
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (281)..(1129)

      <400> 63
 tgaaaatgag tgaagtagtt tgaagccctg agagctgaag aggtggtggt acagatgctg     60

 tctcaaggcc tgaaagcagg gagaacagct tctgaacatc tgcacctggc tgtccaacat    120

 gctggcatct catactcaac atgtcaaaaa ctgaagtttc cccaagattc attttttccc    180

 atgtctgcct ttccttttca atgtcaccac catccaaggc gccgcagagc agcgtgggtg    240

 caggctgcag tggctggcgc cgtcctcgcc cggccaggcc  atg aag gta gag ttt     295
                                              Met Lys Val Glu Phe
                                                1               5

 gca ccg ctc aac atc cag ctg gcg cgg cgg ctg cag acg gtg gcc gtg      343
 Ala Pro Leu Asn Ile Gln Leu Ala Arg Arg Leu Gln Thr Val Ala Val
                  10                  15                  20

 ctg cag tgg gtc ctg aaa tac ctg ctg ctc ggg ccg atg tcc att gga      391
 Leu Gln Trp Val Leu Lys Tyr Leu Leu Leu Gly Pro Met Ser Ile Gly
              25                  30                  35

 atc act gtg atg ctg atc ata cac aac tat ttg ttc ctt tac atc cct      439
 Ile Thr Val Met Leu Ile Ile His Asn Tyr Leu Phe Leu Tyr Ile Pro
          40                  45                  50

 tat ttg atg ggg ctt tac ttt gac tgg cat acc cca gag cga gga ggc      487
 Tyr Leu Met Gly Leu Tyr Phe Asp Trp His Thr Pro Glu Arg Gly Gly
      55                  60                  65

 agg aga tcc agc tgg atc aaa aat tgg act ctt tgg aaa cac ttt aag      535
 Arg Arg Ser Ser Trp Ile Lys Asn Trp Thr Leu Trp Lys His Phe Lys
  70                  75                  80                  85

 gac tat ttt cca att caa ggg ctg gtt tca gtt tcc aag aaa agt gtg      583
 Asp Tyr Phe Pro Ile Gln Gly Leu Val Ser Val Ser Lys Lys Ser Val
                  90                  95                 100

 tcc tac atg gta agc aag gag gga ggt gga aac atc tct gtc att gtc      631
 Ser Tyr Met Val Ser Lys Glu Gly Gly Gly Asn Ile Ser Val Ile Val
             105                 110                 115

 ctt ggg ggt gca aaa gaa tca ctg gat gct cat cct gga aag ttc act      679
 Leu Gly Gly Ala Lys Glu Ser Leu Asp Ala His Pro Gly Lys Phe Thr
         120                 125                 130

 ctg ttc atc cgc cag cgg aaa gga ttt gtt aaa att gct ttg acc cat      727
 Leu Phe Ile Arg Gln Arg Lys Gly Phe Val Lys Ile Ala Leu Thr His
     135                 140                 145

 ggc gcc tct ctg gtc cca gtg gtt tct ttt ggt gaa aat gaa ctg ttt      775
 Gly Ala Ser Leu Val Pro Val Val Ser Phe Gly Glu Asn Glu Leu Phe
 150                 155                 160                 165

 aaa caa act gac aac cct gaa gga tca tgg att aga act gtt cag aat      823
 Lys Gln Thr Asp Asn Pro Glu Gly Ser Trp Ile Arg Thr Val Gln Asn
                 170                 175                 180

 aaa ctg cag aag atc atg ggg ttt gct ttg ccc ctg ttt cat gcc agg      871
 Lys Leu Gln Lys Ile Met Gly Phe Ala Leu Pro Leu Phe His Ala Arg
             185                 190                 195

 gga gtt ttt cag tac aat ttt ggc cta atg acc tat agg aaa gcc atc      919
 Gly Val Phe Gln Tyr Asn Phe Gly Leu Met Thr Tyr Arg Lys Ala Ile
         200                 205                 210

 cac act gtt gtt ggc cgc ccg atc cct gtt cgt cag act ctg aac ccg      967
 His Thr Val Val Gly Arg Pro Ile Pro Val Arg Gln Thr Leu Asn Pro
     215                 220                 225

 acc cag gag cag att gag gag tta cat cag acc tat atg gag gaa ctt     1015
 Thr Gln Glu Gln Ile Glu Glu Leu His Gln Thr Tyr Met Glu Glu Leu
 230                 235                 240                 245

 agg aaa ttg ttt gag gaa cac aaa gga aaa ggt atg cgt ttt aat ctc     1063
 Arg Lys Leu Phe Glu Glu His Lys Gly Lys Gly Met Arg Phe Asn Leu
                 250                 255                 260

 aca gct agt agt gag gag gtg aag ctg acc acc caa cat ccg ctg ggt     1111
 Thr Ala Ser Ser Glu Glu Val Lys Leu Thr Thr Gln His Pro Leu Gly
             265                 270                 275

 tat cca gca ggc agt taa                                             1129
 Tyr Pro Ala Gly Ser 
         280





      <210> 64
      <211> 2055
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (166)..(2001)

      <400> 64
 cacacatgag gttcgtgaca cacacacgag gcagtcgggg agcagaatca ccaaatgcca     60

 aggtcacaca ccaggttccc acgactgtct actactcagt tatttttaac agctgttaaa    120

 tatctcagac tcaccccagc ctgaagctag gtttctgaca ataac    atg cat tta     174
                                                      Met His Leu
                                                        1

 act cta agt tta ctt ctg ttc tcc cta cac ttc ccc acg tat att att      222
 Thr Leu Ser Leu Leu Leu Phe Ser Leu His Phe Pro Thr Tyr Ile Ile
       5                  10                  15

 cga gtt aat ttt tgt ctt gtt tcc aat tta ttt caa agg atg cga agt      270
 Arg Val Asn Phe Cys Leu Val Ser Asn Leu Phe Gln Arg Met Arg Ser
  20                  25                  30                  35

 aca aaa ctg ctt cgg ctc att gac tta gat ttt tca ttt act ttc tct      318
 Thr Lys Leu Leu Arg Leu Ile Asp Leu Asp Phe Ser Phe Thr Phe Ser
                  40                  45                  50

 ctc ttg gat cta cca cca gta aat gaa tat gac atg tat atc aga aac      366
 Leu Leu Asp Leu Pro Pro Val Asn Glu Tyr Asp Met Tyr Ile Arg Asn
              55                  60                  65

 ttt ggg aaa aaa aat acc aag cag gca tat gtt cag tgt aac gaa gat      414
 Phe Gly Lys Lys Asn Thr Lys Gln Ala Tyr Val Gln Cys Asn Glu Asp
          70                  75                  80

 aat gtt gaa aga gac att caa acg gag gaa ata gag acc agg gaa gtg      462
 Asn Val Glu Arg Asp Ile Gln Thr Glu Glu Ile Glu Thr Arg Glu Val
      85                  90                  95

 tgg acc cag cac ccg gga gaa agt act gtt gta tct gga ggc agt gaa      510
 Trp Thr Gln His Pro Gly Glu Ser Thr Val Val Ser Gly Gly Ser Glu
 100                 105                 110                 115

 caa aga gat acc tct gat gct gta gtt atg cca aag att gat act cca      558
 Gln Arg Asp Thr Ser Asp Ala Val Val Met Pro Lys Ile Asp Thr Pro
                 120                 125                 130

 agg tta tgt agc ttt ctg cgg gct gct tgt cag gtg atg gcc gtt ttg      606
 Arg Leu Cys Ser Phe Leu Arg Ala Ala Cys Gln Val Met Ala Val Leu
             135                 140                 145

 ctg gaa gag gat cgc ttg gca gct gaa ccc agc tgg aat ctt agg gct      654
 Leu Glu Glu Asp Arg Leu Ala Ala Glu Pro Ser Trp Asn Leu Arg Ala
         150                 155                 160

 caa gac agg gcc ctg tat ttt agt gac agc tca tct cag ctg aac acc      702
 Gln Asp Arg Ala Leu Tyr Phe Ser Asp Ser Ser Ser Gln Leu Asn Thr
     165                 170                 175

 agt cta cca ttc ctt caa aat cga aaa gta tcc tcc ttg cac acc tcc      750
 Ser Leu Pro Phe Leu Gln Asn Arg Lys Val Ser Ser Leu His Thr Ser
 180                 185                 190                 195

 cga gtt cag agg cag atg gtg gtc tcc gtt cac gac tta ccc gag aag      798
 Arg Val Gln Arg Gln Met Val Val Ser Val His Asp Leu Pro Glu Lys
                 200                 205                 210

 agc ttt gtg ccc ctg ctg gac agc aaa tac gtc ctc tgt gtg tgg gat      846
 Ser Phe Val Pro Leu Leu Asp Ser Lys Tyr Val Leu Cys Val Trp Asp
             215                 220                 225

 att tgg cag cct tca ggg cca cag aag gtt ctg ata tgt gag tcc cag      894
 Ile Trp Gln Pro Ser Gly Pro Gln Lys Val Leu Ile Cys Glu Ser Gln
         230                 235                 240

 gtc acg tgt tgc tgc ttg agc cct ttg aaa gca ttt tta ctg ttt gcc      942
 Val Thr Cys Cys Cys Leu Ser Pro Leu Lys Ala Phe Leu Leu Phe Ala
     245                 250                 255

 gga aca gcg cac ggc tca gtt gtc gtc tgg gat ttg aga gaa gac tca      990
 Gly Thr Ala His Gly Ser Val Val Val Trp Asp Leu Arg Glu Asp Ser
 260                 265                 270                 275

 agg ctg cat tac tct gtg acg ctg agc gat ggc ttc tgg acg ttc cgg     1038
 Arg Leu His Tyr Ser Val Thr Leu Ser Asp Gly Phe Trp Thr Phe Arg
                 280                 285                 290

 acc gcc acg ttt tcc acc gat gga atc ctt acc tca gta aac cac cga     1086
 Thr Ala Thr Phe Ser Thr Asp Gly Ile Leu Thr Ser Val Asn His Arg
             295                 300                 305

 agc cct ctt caa gca gta gaa cct atc tca acg tcc gtc cac aaa aag     1134
 Ser Pro Leu Gln Ala Val Glu Pro Ile Ser Thr Ser Val His Lys Lys
         310                 315                 320

 cag agc ttt gtg ctt tca ccc ttt tct act caa gaa gaa atg tca ggt     1182
 Gln Ser Phe Val Leu Ser Pro Phe Ser Thr Gln Glu Glu Met Ser Gly
     325                 330                 335

 ttg tcc ttc cac atc gct tcc ttg gat gag agt ggg gtt ctc aat gta     1230
 Leu Ser Phe His Ile Ala Ser Leu Asp Glu Ser Gly Val Leu Asn Val
 340                 345                 350                 355

 tgg gtg gtt gtt gaa tta cca aag gca gac atc gca ggt tca ata agt     1278
 Trp Val Val Val Glu Leu Pro Lys Ala Asp Ile Ala Gly Ser Ile Ser
                 360                 365                 370

 gat tta ggt ctg atg cct gga ggg agg gtc aag ctg gta cat agt gct     1326
 Asp Leu Gly Leu Met Pro Gly Gly Arg Val Lys Leu Val His Ser Ala
             375                 380                 385

 ctg atc cag ttg ggt gac agt ctt tcc cat aaa ggt aat gaa ttt tgg     1374
 Leu Ile Gln Leu Gly Asp Ser Leu Ser His Lys Gly Asn Glu Phe Trp
         390                 395                 400

 ggc act aca caa aca ctg aat gtt aaa ttt ctg cct tca gat cct aat     1422
 Gly Thr Thr Gln Thr Leu Asn Val Lys Phe Leu Pro Ser Asp Pro Asn
     405                 410                 415

 cac ttt att att ggc aca gac atg ggt ctc ata agc cat ggc aca aga     1470
 His Phe Ile Ile Gly Thr Asp Met Gly Leu Ile Ser His Gly Thr Arg
 420                 425                 430                 435

 caa gat ttg aga gtg gct ccc aaa cta ttc aaa cct cag caa cat ggt     1518
 Gln Asp Leu Arg Val Ala Pro Lys Leu Phe Lys Pro Gln Gln His Gly
                 440                 445                 450

 ata aga cca gtg aaa gtt aat gtc att gat ttt tca cca ttt gga gaa     1566
 Ile Arg Pro Val Lys Val Asn Val Ile Asp Phe Ser Pro Phe Gly Glu
             455                 460                 465

 cca ata ttt ttg gcc ggc tgt tcg gac gga agc atc agg ctg cac cag     1614
 Pro Ile Phe Leu Ala Gly Cys Ser Asp Gly Ser Ile Arg Leu His Gln
         470                 475                 480

 ctg agc tcc gcg ttt ccg ctc ctg cag tgg gac agc agc acg gac agc     1662
 Leu Ser Ser Ala Phe Pro Leu Leu Gln Trp Asp Ser Ser Thr Asp Ser
     485                 490                 495

 cat gcg gtc acc ggc ctg cag tgg tcc cca acc agg cct gcc gtg ttc     1710
 His Ala Val Thr Gly Leu Gln Trp Ser Pro Thr Arg Pro Ala Val Phe
 500                 505                 510                 515

 ctg gtg cag gac gac aca tcc aac atc tac atc tgg gac ctc ctc cag     1758
 Leu Val Gln Asp Asp Thr Ser Asn Ile Tyr Ile Trp Asp Leu Leu Gln
                 520                 525                 530

 agc gat ctg ggt cct gtc gcc aaa cag cag gtc tcc ccc aac agg ctg     1806
 Ser Asp Leu Gly Pro Val Ala Lys Gln Gln Val Ser Pro Asn Arg Leu
             535                 540                 545

 gtg gcc atg gct gcg gtg ggt gag cct gag aag gct ggt ggc agc ttc     1854
 Val Ala Met Ala Ala Val Gly Glu Pro Glu Lys Ala Gly Gly Ser Phe
         550                 555                 560

 ctg gcc ctg gtg ctg gcc agg gcg tct ggc tcc atc gac atc cag cac     1902
 Leu Ala Leu Val Leu Ala Arg Ala Ser Gly Ser Ile Asp Ile Gln His
     565                 570                 575

 ctg aag agg cgg tgg gcg gcc ccg gag gtg gac gag tgc aac agg ctg     1950
 Leu Lys Arg Arg Trp Ala Ala Pro Glu Val Asp Glu Cys Asn Arg Leu
 580                 585                 590                 595

 cgt ctg ctt ttg cag gaa gcc ctg tgg cca gag gga aaa ctg cac aag     1998
 Arg Leu Leu Leu Gln Glu Ala Leu Trp Pro Glu Gly Lys Leu His Lys
                 600                 605                 610

 tag cggg tgtggctgag aggaccgcgt ttctgtaatg acccagattt aaaagacata     2055
 






      <210> 65
      <211> 437
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (34)..(426)

      <400> 65
 cactccagga cacccacacg ggccttctgg gcg atg acg ctc ctg gcc cag gag      54
                                      Met Thr Leu Leu Ala Gln Glu
                                        1               5

 tgg ggg gct gcc tca cac ctg ctg ctg tgg ggc aga gtc tct cct ggg      102
 Trp Gly Ala Ala Ser His Leu Leu Leu Trp Gly Arg Val Ser Pro Gly
          10                  15                  20

 tcg ggg cct cgc tgg cgg atc tgc tcc atg tcg tgt gat gtg ctg cag      150
 Ser Gly Pro Arg Trp Arg Ile Cys Ser Met Ser Cys Asp Val Leu Gln
      25                  30                  35

 ccc cgc gtc acc gag agc ctc tta tgg gcc acc aag tcc aca cag cca      198
 Pro Arg Val Thr Glu Ser Leu Leu Trp Ala Thr Lys Ser Thr Gln Pro
  40                  45                  50                  55

 ctg gcc atg ggg cac cct gca ggg cct ctg gac acg gag acc tgt ggt      246
 Leu Ala Met Gly His Pro Ala Gly Pro Leu Asp Thr Glu Thr Cys Gly
                  60                  65                  70

 tct cag cca gtg gtg att ttg tgt cca ggg aac acc tgg cca agt ctg      294
 Ser Gln Pro Val Val Ile Leu Cys Pro Gly Asn Thr Trp Pro Ser Leu
              75                  80                  85

 ggt tca att ttg ttt gtc aca gtt tac ggt tgg ggt gtc act aga cat      342
 Gly Ser Ile Leu Phe Val Thr Val Tyr Gly Trp Gly Val Thr Arg His
          90                  95                 100

 cct aca gtg cac agg acg gcc cac agc aga cac ccc act gtc agc agc      390
 Pro Thr Val His Arg Thr Ala His Ser Arg His Pro Thr Val Ser Ser
     105                 110                 115

 acg agc cgg aaa cct ggt ctg aag cgt tct ctc tag ggtcctgcta g         437
 Thr Ser Arg Lys Pro Gly Leu Lys Arg Ser Leu 
 120                 125                 130





      <210> 66
      <211> 2208
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (1)..(2208)

      <400> 66
  atg agg gtc ctt ctc cat ctc cca gcc ctc ctg gct tcc ctc atc ttg      48
  Met Arg Val Leu Leu His Leu Pro Ala Leu Leu Ala Ser Leu Ile Leu
    1               5                  10                  15

 ctt cag gct gca gca tct acc aca aga gcg cag act acc aga acc tct       96
 Leu Gln Ala Ala Ala Ser Thr Thr Arg Ala Gln Thr Thr Arg Thr Ser
              20                  25                  30

 gcc atc tcc gat act gtg agt cag gcc aag gtc caa gtc aac aag gcc      144
 Ala Ile Ser Asp Thr Val Ser Gln Ala Lys Val Gln Val Asn Lys Ala
          35                  40                  45

 ttc ctg gac tcc cga acc agg ctg aag acc gcc atg agc tct gag act      192
 Phe Leu Asp Ser Arg Thr Arg Leu Lys Thr Ala Met Ser Ser Glu Thr
      50                  55                  60

 ccc acc agc cga cag ctc tca gaa tac ctc aag cat gcc aaa ggc cgg      240
 Pro Thr Ser Arg Gln Leu Ser Glu Tyr Leu Lys His Ala Lys Gly Arg
  65                  70                  75                  80

 acg cgc aca gcc atc cgc aat gga cag gtg tgg gag gag tct tta aag      288
 Thr Arg Thr Ala Ile Arg Asn Gly Gln Val Trp Glu Glu Ser Leu Lys
                  85                  90                  95

 aga ctg agg cag aag gca tcc ttg acc aat gtc aca gat ccc agc ctg      336
 Arg Leu Arg Gln Lys Ala Ser Leu Thr Asn Val Thr Asp Pro Ser Leu
             100                 105                 110

 gac ttg act tca ctg tct ctg gag gtg ggc tgt ggt gct cct gct ccc      384
 Asp Leu Thr Ser Leu Ser Leu Glu Val Gly Cys Gly Ala Pro Ala Pro
         115                 120                 125

 gtg gtg aga tgc gac ccg tgc agc cct tac cgc acc att acg gga gac      432
 Val Val Arg Cys Asp Pro Cys Ser Pro Tyr Arg Thr Ile Thr Gly Asp
     130                 135                 140

 tgc aat aac agg agg aag cct gcg ctg ggc gcc gcc aac agg gct ctg      480
 Cys Asn Asn Arg Arg Lys Pro Ala Leu Gly Ala Ala Asn Arg Ala Leu
 145                 150                 155                 160

 gcg cgc tgg ctg ccc gcg gag tac gag gac ggg ctc tcc ctg ccc ttc      528
 Ala Arg Trp Leu Pro Ala Glu Tyr Glu Asp Gly Leu Ser Leu Pro Phe
                 165                 170                 175

 ggc tgg acg ccg ggg aag acg cgc aac ggc ttc cct ctc ccg ctg gcc      576
 Gly Trp Thr Pro Gly Lys Thr Arg Asn Gly Phe Pro Leu Pro Leu Ala
             180                 185                 190

 cgg gag gta tct aac aag att gtt ggc tat ctg aat gag gag ggt gtt      624
 Arg Glu Val Ser Asn Lys Ile Val Gly Tyr Leu Asn Glu Glu Gly Val
         195                 200                 205

 ctg gac caa aac agg tcc ctg ctc ttc atg cag tgg ggt cag att gtg      672
 Leu Asp Gln Asn Arg Ser Leu Leu Phe Met Gln Trp Gly Gln Ile Val
     210                 215                 220

 gat cat gac ctg gac ttt gcc cct gac acc gag ctg ggg agt agc gag      720
 Asp His Asp Leu Asp Phe Ala Pro Asp Thr Glu Leu Gly Ser Ser Glu
 225                 230                 235                 240

 tac tcc aaa gcc cag tgt gat gag tac tgt atc cag gga gac aac tgc      768
 Tyr Ser Lys Ala Gln Cys Asp Glu Tyr Cys Ile Gln Gly Asp Asn Cys
                 245                 250                 255

 ttc ccc atc atg ttc cca ccc aat gac ccc aag gcg ggg act caa ggg      816
 Phe Pro Ile Met Phe Pro Pro Asn Asp Pro Lys Ala Gly Thr Gln Gly
             260                 265                 270

 aaa tgc atg cct ttc ttc cga gct ggg ttc gtc tgc ccc act cca ccc      864
 Lys Cys Met Pro Phe Phe Arg Ala Gly Phe Val Cys Pro Thr Pro Pro
         275                 280                 285

 tac aag tcc ctg gcc cga gag cag atc aac gct ctg acc tcc ttc ctg      912
 Tyr Lys Ser Leu Ala Arg Glu Gln Ile Asn Ala Leu Thr Ser Phe Leu
     290                 295                 300

 gat gcc agc ttt gtg tac agc tcc gag cca agc ctg gcc agc cgc ctc      960
 Asp Ala Ser Phe Val Tyr Ser Ser Glu Pro Ser Leu Ala Ser Arg Leu
 305                 310                 315                 320

 cgc aac ctc agc agc ccc ctg ggc ctc atg gct gtc aac cag gag gtc     1008
 Arg Asn Leu Ser Ser Pro Leu Gly Leu Met Ala Val Asn Gln Glu Val
                 325                 330                 335

 tca gac cat gga cta ccc tac ctg ccc tat gac agc aag aag cca agc     1056
 Ser Asp His Gly Leu Pro Tyr Leu Pro Tyr Asp Ser Lys Lys Pro Ser
             340                 345                 350

 ccc tgt gag ttc atc aac acc act gcc cgt gtg ccc tgc ttc ctg gca     1104
 Pro Cys Glu Phe Ile Asn Thr Thr Ala Arg Val Pro Cys Phe Leu Ala
         355                 360                 365

 gga gat tct cga gcc tca gag cat att ctg ctg gcc aca tcc cac acc     1152
 Gly Asp Ser Arg Ala Ser Glu His Ile Leu Leu Ala Thr Ser His Thr
     370                 375                 380

 ctc ttt ctc cgc gag cat aac cgg ctg gcc aga gaa cta aag aga ctc     1200
 Leu Phe Leu Arg Glu His Asn Arg Leu Ala Arg Glu Leu Lys Arg Leu
 385                 390                 395                 400

 aac cct cag tgg gat gga gag aag ctc tac cag gaa gcc cgg aaa atc     1248
 Asn Pro Gln Trp Asp Gly Glu Lys Leu Tyr Gln Glu Ala Arg Lys Ile
                 405                 410                 415

 ctg gga gcc ttc gtg cag att atc acc ttt agg gac tac cta ccc att     1296
 Leu Gly Ala Phe Val Gln Ile Ile Thr Phe Arg Asp Tyr Leu Pro Ile
             420                 425                 430

 ttg cta ggt gac cac atg cag aag tgg ata ccc cca tat caa ggc tac     1344
 Leu Leu Gly Asp His Met Gln Lys Trp Ile Pro Pro Tyr Gln Gly Tyr
         435                 440                 445

 agt gaa tct gtg gat ccc aga att tcc aat gtc ttc acc ttc gcc ttc     1392
 Ser Glu Ser Val Asp Pro Arg Ile Ser Asn Val Phe Thr Phe Ala Phe
     450                 455                 460

 cgc ttt ggc cac ttg gag gtc ccc tct agt atg ttc cgc ctg gat gag     1440
 Arg Phe Gly His Leu Glu Val Pro Ser Ser Met Phe Arg Leu Asp Glu
 465                 470                 475                 480

 aat tat cag cca tgg ggg cca gaa cca gaa ctc ccc ctc cac acc ctc     1488
 Asn Tyr Gln Pro Trp Gly Pro Glu Pro Glu Leu Pro Leu His Thr Leu
                 485                 490                 495

 ttc ttc aac act tgg agg atg gtc aaa gat ggt gga att gat cct ctg     1536
 Phe Phe Asn Thr Trp Arg Met Val Lys Asp Gly Gly Ile Asp Pro Leu
             500                 505                 510

 gtg cgg ggc ctg ctg gcc aag aaa tcc aag ctg atg aaa cag aat aaa     1584
 Val Arg Gly Leu Leu Ala Lys Lys Ser Lys Leu Met Lys Gln Asn Lys
         515                 520                 525

 atg atg act gga gag ctg cgc aac aag ctt ttc cag cca act cac agg     1632
 Met Met Thr Gly Glu Leu Arg Asn Lys Leu Phe Gln Pro Thr His Arg
     530                 535                 540

 atc cat ggc ttt gac ctg gct gcc atc aac aca cag cgt tgc cgg gac     1680
 Ile His Gly Phe Asp Leu Ala Ala Ile Asn Thr Gln Arg Cys Arg Asp
 545                 550                 555                 560

 cat ggg caa cct ggg tac aat tcc tgg aga gcc ttc tgt gac ctc tca     1728
 His Gly Gln Pro Gly Tyr Asn Ser Trp Arg Ala Phe Cys Asp Leu Ser
                 565                 570                 575

 cag ccg cag aca cta gag gag ttg aac aca gtg ctg aag agc aag atg     1776
 Gln Pro Gln Thr Leu Glu Glu Leu Asn Thr Val Leu Lys Ser Lys Met
             580                 585                 590

 ctg gcc aag aag tta ctg ggt ctc tac ggg acc cct gac aac atc gac     1824
 Leu Ala Lys Lys Leu Leu Gly Leu Tyr Gly Thr Pro Asp Asn Ile Asp
         595                 600                 605

 atc tgg ata ggg gcc att gct gag ccg ctg gtg gaa agg ggt cgg gtg     1872
 Ile Trp Ile Gly Ala Ile Ala Glu Pro Leu Val Glu Arg Gly Arg Val
     610                 615                 620

 ggg cct ctc ctg gcc tgc ctc ttg ggc aag cag ttc cag cag atc cgt     1920
 Gly Pro Leu Leu Ala Cys Leu Leu Gly Lys Gln Phe Gln Gln Ile Arg
 625                 630                 635                 640

 gat gga gac agg caa gtg cgt cct cag cca ggg agg gaa ggg cag ggc     1968
 Asp Gly Asp Arg Gln Val Arg Pro Gln Pro Gly Arg Glu Gly Gln Gly
                 645                 650                 655

 cct tct cca aga ggg gtg tcc caa ggt cct gcg ttc tgg tgg gaa aac     2016
 Pro Ser Pro Arg Gly Val Ser Gln Gly Pro Ala Phe Trp Trp Glu Asn
             660                 665                 670

 cct ggg gtc ttc acg aac gag cag aag gac tct cta cag aaa atg tcc     2064
 Pro Gly Val Phe Thr Asn Glu Gln Lys Asp Ser Leu Gln Lys Met Ser
         675                 680                 685

 ttc tca cgc ctt gtc tgt gac aac acc cgc atc acc aag gtc cca cgg     2112
 Phe Ser Arg Leu Val Cys Asp Asn Thr Arg Ile Thr Lys Val Pro Arg
     690                 695                 700

 gac cca ttc tgg gcc aac agc tac ccc tat gac ttc gtg gat tgc tca     2160
 Asp Pro Phe Trp Ala Asn Ser Tyr Pro Tyr Asp Phe Val Asp Cys Ser
 705                 710                 715                 720

 gcc atc gac aag ctg gac ctg tca ccc tgg gcc tca gtg aag aat tag     2208
 Ala Ile Asp Lys Leu Asp Leu Ser Pro Trp Ala Ser Val Lys Asn 
                 725                 730                 735





      <210> 67
      <211> 712
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (338)..(712)

      <400> 67
 gcctgatggt gtcaaggctc ttatggtcag ctccaaccta gcgcaggctc acttcaatat     60

 tctctggaaa ttcaaatgca tgtgtatgag agaacagttt caaccacgtc tacactggaa    120

 gtctacactt gtagaaattc atggaaaaat cgattggggt aggggtcatg gatggcaaca    180

 gcctcagacc acagcgcccc aacccaaggg ttgtcaagga aaacaagagc ctcaccagaa    240

 ccaggggact ccaaggaatc tcaccttgat ggtgaggtca ccactaaacc agcctctcct    300

 tactgctacc gggtagggac ctcaccaccg ccaggtc atg gtg ctg gct cac atc     355
                                          Met Val Leu Ala His Ile
                                            1               5

 cag tac ctg gac ccc tgc tta gct gct ctc tta gct cat gct ttg ttg      403
 Gln Tyr Leu Asp Pro Cys Leu Ala Ala Leu Leu Ala His Ala Leu Leu
              10                  15                  20

 cgt acc ctg cag gtg act aca gtt agg agg acc ctc acc ctc ctc tct      451
 Arg Thr Leu Gln Val Thr Thr Val Arg Arg Thr Leu Thr Leu Leu Ser
          25                  30                  35

 gcc ttt ctc ctg gtg gcc ctt cag gcc tgg gca gag ccg ctc ccc gca      499
 Ala Phe Leu Leu Val Ala Leu Gln Ala Trp Ala Glu Pro Leu Pro Ala
      40                  45                  50

 aga gct cat gag atg cca gcc cag aag cag cct cca gca gat gac cag      547
 Arg Ala His Glu Met Pro Ala Gln Lys Gln Pro Pro Ala Asp Asp Gln
  55                  60                  65                  70

 gat gtg gtc ctt tac ttt tca gga gat gac agc tgc tct ctt cag gtt      595
 Asp Val Val Leu Tyr Phe Ser Gly Asp Asp Ser Cys Ser Leu Gln Val
                  75                  80                  85

 cca ggc tca aca aag ggc ttg atc tgc cat tgc aga gta cta tac tgc      643
 Pro Gly Ser Thr Lys Gly Leu Ile Cys His Cys Arg Val Leu Tyr Cys
              90                  95                 100

 att ttt gga gaa cat ctt ggt ggg acc tgc ttc atc ctt ggt gaa cgc      691
 Ile Phe Gly Glu His Leu Gly Gly Thr Cys Phe Ile Leu Gly Glu Arg
         105                 110                 115

 tac cca atc tgc tgc tac taa                                          712
 Tyr Pro Ile Cys Cys Tyr 
     120





      <210> 68
      <211> 471
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (1)..(471)

      <400> 68
  atg gag gcc ctg agg agg gcc cac gag gtc gcg ctc cgc ctg ctg ctg      48
  Met Glu Ala Leu Arg Arg Ala His Glu Val Ala Leu Arg Leu Leu Leu
    1               5                  10                  15

 tgt agg ccg tgg gcc tcg cgc gcc gcc gcc cgc ccc aag ccc agc gcc       96
 Cys Arg Pro Trp Ala Ser Arg Ala Ala Ala Arg Pro Lys Pro Ser Ala
              20                  25                  30

 tcg gag gtg ctg acg cgg cat ctg ctg cag cgg cgc ctg ccg cac tgg      144
 Ser Glu Val Leu Thr Arg His Leu Leu Gln Arg Arg Leu Pro His Trp
          35                  40                  45

 acc tcc ttc tgc gtg ccc tac agc gcc gtc cgc aac gac cag ttc ggc      192
 Thr Ser Phe Cys Val Pro Tyr Ser Ala Val Arg Asn Asp Gln Phe Gly
      50                  55                  60

 ctc tcg cac ttc aac tgg ccg gtg cag ggc gcc aac tac cac gtc ctg      240
 Leu Ser His Phe Asn Trp Pro Val Gln Gly Ala Asn Tyr His Val Leu
  65                  70                  75                  80

 cgc acc ggc tgc ttc ccc ttc atc aag tac cac tgc tcc aag gct ccc      288
 Arg Thr Gly Cys Phe Pro Phe Ile Lys Tyr His Cys Ser Lys Ala Pro
                  85                  90                  95

 tgg cag gac ctg gcc cgg cag aac cgc ttc ttc acg gcg ctc aag gtc      336
 Trp Gln Asp Leu Ala Arg Gln Asn Arg Phe Phe Thr Ala Leu Lys Val
             100                 105                 110

 gtc aac ctc ggt att cca act tta tta tat gga ctt ggc tcc tgg tta      384
 Val Asn Leu Gly Ile Pro Thr Leu Leu Tyr Gly Leu Gly Ser Trp Leu
         115                 120                 125

 ttt gcc aga gtc aca gag act gtg cat acc agt tat gga ccc ata aca      432
 Phe Ala Arg Val Thr Glu Thr Val His Thr Ser Tyr Gly Pro Ile Thr
     130                 135                 140

 gtt tat ttt ctc aat aaa gaa gat gaa ggt gcc atg taa                  471
 Val Tyr Phe Leu Asn Lys Glu Asp Glu Gly Ala Met 
 145                 150                 155





      <210> 69
      <211> 1069
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (77)..(586)

      <400> 69
 ataaaggcta cttaagcagt gatccactgt ttgaattcaa aggttgagaa catcattgta     60

 ccatcaaggt ctagaa    atg ctg cta acc ctg agc ggg ttg tta ctg ttt     109
                      Met Leu Leu Thr Leu Ser Gly Leu Leu Leu Phe
                        1               5                  10

 gaa aag cct atg ggt att tgt ttt att gtt gtc tca ttc aat tct tac      157
 Glu Lys Pro Met Gly Ile Cys Phe Ile Val Val Ser Phe Asn Ser Tyr
              15                  20                  25

 tta gct gag agt atc tca caa ggg aag tac tgc tct gtg atg gtg tcc      205
 Leu Ala Glu Ser Ile Ser Gln Gly Lys Tyr Cys Ser Val Met Val Ser
          30                  35                  40

 tgg act ttg ttt tct att tgt ttc agc act tca ata aat ggt ctg tta      253
 Trp Thr Leu Phe Ser Ile Cys Phe Ser Thr Ser Ile Asn Gly Leu Leu
      45                  50                  55

 cct gcc att atg acc tgt atg cat ttg ctg agc agt ttt tca aaa caa      301
 Pro Ala Ile Met Thr Cys Met His Leu Leu Ser Ser Phe Ser Lys Gln
  60                  65                  70                  75

 aac aaa tta tgt ggc tgt att tct aga acg ctg agc cat ttt caa gat      349
 Asn Lys Leu Cys Gly Cys Ile Ser Arg Thr Leu Ser His Phe Gln Asp
                  80                  85                  90

 agt ata gaa tta gaa aca cac ata gac acg tcc aca caa ttg tat gtt      397
 Ser Ile Glu Leu Glu Thr His Ile Asp Thr Ser Thr Gln Leu Tyr Val
              95                 100                 105

 tat act gaa cac ata tat tca gac ata ttc agg aaa ata aga aaa aag      445
 Tyr Thr Glu His Ile Tyr Ser Asp Ile Phe Arg Lys Ile Arg Lys Lys
         110                 115                 120

 aaa ata ggt tgg aca ata caa ata tgg aaa tac agc ttg ttc aat cat      493
 Lys Ile Gly Trp Thr Ile Gln Ile Trp Lys Tyr Ser Leu Phe Asn His
     125                 130                 135

 tta gag ccc ata ctt cta acg gtg tac ata tgt aga cgt gac ttt gta      541
 Leu Glu Pro Ile Leu Leu Thr Val Tyr Ile Cys Arg Arg Asp Phe Val
 140                 145                 150                 155

 aag aag acc cac atg tgt gtc tac act caa gca tct tcc tct taa tac      589
 Lys Lys Thr His Met Cys Val Tyr Thr Gln Ala Ser Ser Ser 
                 160                 165

 tctactgagg ataaaggaca caaagtaatt tttgaaatat catgctggct acttttagag    649

 tatattagtg tgagtagtga cttaagaggt caggtttaag agaagtagca acatacttct    709

 attatttaca tggtgatttt tttttataag tccttcctga aggcagactt agatatttca    769

 agacctcctt agaaaaattt ttcagcacct tctgtgctcc aaattgagtc agtttgcatc    829

 atgtttcagt gtaactgagt aacaggctag caaattctct gctttcttat tcaccaaaat    889

 ccaaaataga actcacaaaa actccttcct tcttcccccc atcctgaaaa aacaccctac    949

 tgtggccccc cccagtagag gaacagacca gaaaaaaaaa gagtaaacag agccagctgt   1009

 aactatagca ctttgctcag tactgtgagc ttgctagagc tggcacattt tttataatac   1069




      <210> 70
      <211> 655
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (8)..(655)

      <400> 70
 aaggatc  atg ggt ttt gtt ttc ttt att ttc ttc ttt tgc aag gat tgc      49
          Met Gly Phe Val Phe Phe Ile Phe Phe Phe Cys Lys Asp Cys
            1               5                  10

 cat act aag gaa ttc ctc att ata ttt tgt gtt gtt ccc att gca gcc       97
 His Thr Lys Glu Phe Leu Ile Ile Phe Cys Val Val Pro Ile Ala Ala
  15                  20                  25                  30

 agt cag aaa tct tcc aac ttg gaa ggg aga acg aag tca gtc acc agg      145
 Ser Gln Lys Ser Ser Asn Leu Glu Gly Arg Thr Lys Ser Val Thr Arg
                  35                  40                  45

 cag act ggg tca tct gct gaa atc act tgt gac ctt act gta ata aat      193
 Gln Thr Gly Ser Ser Ala Glu Ile Thr Cys Asp Leu Thr Val Ile Asn
              50                  55                  60

 gcc ttc tac atc cac tgg tac cta cac cag gag ggg aag gcc cca cag      241
 Ala Phe Tyr Ile His Trp Tyr Leu His Gln Glu Gly Lys Ala Pro Gln
          65                  70                  75

 cgt ctt ctg tac tat gac gtc tcc aac tca agg gat gtg ttg gaa tca      289
 Arg Leu Leu Tyr Tyr Asp Val Ser Asn Ser Arg Asp Val Leu Glu Ser
      80                  85                  90

 gga ctc agt cca gga aag tat tat act cat aca ccg agg agg tgg agc      337
 Gly Leu Ser Pro Gly Lys Tyr Tyr Thr His Thr Pro Arg Arg Trp Ser
  95                 100                 105                 110

 tgg aat ttg aga ctg caa aat cta att gaa aat gat tct ggg gtc tat      385
 Trp Asn Leu Arg Leu Gln Asn Leu Ile Glu Asn Asp Ser Gly Val Tyr
                 115                 120                 125

 tac tgt gcc acc tgg ggc agg cac agt gat tca gat ctg ccc tac acc      433
 Tyr Cys Ala Thr Trp Gly Arg His Ser Asp Ser Asp Leu Pro Tyr Thr
             130                 135                 140

 aca ctg aac atc tgc ctt gtg gct gcc tct ggt aca caa gat aga gcc      481
 Thr Leu Asn Ile Cys Leu Val Ala Ala Ser Gly Thr Gln Asp Arg Ala
         145                 150                 155

 gcc ccc tct cat ttc ctg cca cca aat tta ctg tat tct gaa caa gag      529
 Ala Pro Ser His Phe Leu Pro Pro Asn Leu Leu Tyr Ser Glu Gln Glu
     160                 165                 170

 aaa gac agc tta act cct gat ctc cct cct aat atc aca ctg tcc tgg      577
 Lys Asp Ser Leu Thr Pro Asp Leu Pro Pro Asn Ile Thr Leu Ser Trp
 175                 180                 185                 190

 cag cag ctg cac cct gtt ccc tac ccc tcc ccc aca act ttc ctg aag      625
 Gln Gln Leu His Pro Val Pro Tyr Pro Ser Pro Thr Thr Phe Leu Lys
                 195                 200                 205

 atc aag ctg cca tct ccg ggc ctc agt taa                              655
 Ile Lys Leu Pro Ser Pro Gly Leu Ser 
             210                 215





      <210> 71
      <211> 819
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (1)..(819)

      <400> 71
  atg aag aca ttt gct gga ttt tcg ttc ctg ttt ttg tgg ctg cag ctg      48
  Met Lys Thr Phe Ala Gly Phe Ser Phe Leu Phe Leu Trp Leu Gln Leu
    1               5                  10                  15

 gac tgt atg agt aga gga gag gat gtg gag cag agt ctt ttc ctg agt       96
 Asp Cys Met Ser Arg Gly Glu Asp Val Glu Gln Ser Leu Phe Leu Ser
              20                  25                  30

 gtc cga gag gga gac agc tcc gtt ata aac tgc act tac aca gac agc      144
 Val Arg Glu Gly Asp Ser Ser Val Ile Asn Cys Thr Tyr Thr Asp Ser
          35                  40                  45

 tcc tcc acc tac tta tac tgg tat aag caa gaa cct gga gca ggt ctc      192
 Ser Ser Thr Tyr Leu Tyr Trp Tyr Lys Gln Glu Pro Gly Ala Gly Leu
      50                  55                  60

 cag ttg ctg acg tat att ttt tca aat atg gac atg aaa caa gac caa      240
 Gln Leu Leu Thr Tyr Ile Phe Ser Asn Met Asp Met Lys Gln Asp Gln
  65                  70                  75                  80

 aga ctc act gtt cta ttg aat aaa aag gat aaa cat ctg tct ctg cgc      288
 Arg Leu Thr Val Leu Leu Asn Lys Lys Asp Lys His Leu Ser Leu Arg
                  85                  90                  95

 att gca gac acc cag act ggg gac tca gct atc tac ttc tgt gct ttg      336
 Ile Ala Asp Thr Gln Thr Gly Asp Ser Ala Ile Tyr Phe Cys Ala Leu
             100                 105                 110

 gac acg ggc agg aga gca ctt act ttt ggg agt gga aca aga ctc caa      384
 Asp Thr Gly Arg Arg Ala Leu Thr Phe Gly Ser Gly Thr Arg Leu Gln
         115                 120                 125

 gtg caa cca aat atc cag aac cct gac cct gcc gtg tac cag ctg aga      432
 Val Gln Pro Asn Ile Gln Asn Pro Asp Pro Ala Val Tyr Gln Leu Arg
     130                 135                 140

 gac tct aaa tcc agt gac aag tct gtc tgc cta ttc acc gat ttt gat      480
 Asp Ser Lys Ser Ser Asp Lys Ser Val Cys Leu Phe Thr Asp Phe Asp
 145                 150                 155                 160

 tct caa aca aat gtg tca caa agt aag gat tct gat gtg tat atc aca      528
 Ser Gln Thr Asn Val Ser Gln Ser Lys Asp Ser Asp Val Tyr Ile Thr
                 165                 170                 175

 gac aaa act gtg cta gac atg agg tct atg gac ttc aag agc aac agt      576
 Asp Lys Thr Val Leu Asp Met Arg Ser Met Asp Phe Lys Ser Asn Ser
             180                 185                 190

 gct gtg gcc tgg agc aac aaa tct gac ttt gca tgt gca aac gcc ttc      624
 Ala Val Ala Trp Ser Asn Lys Ser Asp Phe Ala Cys Ala Asn Ala Phe
         195                 200                 205

 aac aac agc att att cca gaa gac acc ttc ttc ccc agc cca gaa agt      672
 Asn Asn Ser Ile Ile Pro Glu Asp Thr Phe Phe Pro Ser Pro Glu Ser
     210                 215                 220

 tcc tgt gat gtc aag ctg gtc gag aaa agc ttt gaa aca gat acg aac      720
 Ser Cys Asp Val Lys Leu Val Glu Lys Ser Phe Glu Thr Asp Thr Asn
 225                 230                 235                 240

 cta aac ttt caa aac ctg tca gtg att ggg ttc cga atc ctc ctc ctg      768
 Leu Asn Phe Gln Asn Leu Ser Val Ile Gly Phe Arg Ile Leu Leu Leu
                 245                 250                 255

 aaa gtg gcc ggg ttt aat ctg ctc atg acg ctg cgg ctg tgg tcc agc      816
 Lys Val Ala Gly Phe Asn Leu Leu Met Thr Leu Arg Leu Trp Ser Ser
             260                 265                 270

 tga                                                                  819
 






      <210> 72
      <211> 1095
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (25)..(1095)

      <400> 72
 ccagttgcaa gagctctgga aaag   atg ttg gtg cta aac tgt tct acc aaa      51
                              Met Leu Val Leu Asn Cys Ser Thr Lys
                                1               5

 tta ctg ata ctg gag aaa acg ttg aag agt tgc ttt cct gaa tct ctc       99
 Leu Leu Ile Leu Glu Lys Thr Leu Lys Ser Cys Phe Pro Glu Ser Leu
  10                  15                  20                  25

 aag gtt tac gga gcg gtg atg aac ata aat cgt ggg aac ccc ttt caa      147
 Lys Val Tyr Gly Ala Val Met Asn Ile Asn Arg Gly Asn Pro Phe Gln
                  30                  35                  40

 aag gaa gtg gtg ttg gat tca tgg ccg gat ttc aaa gct gtt atc acc      195
 Lys Glu Val Val Leu Asp Ser Trp Pro Asp Phe Lys Ala Val Ile Thr
              45                  50                  55

 cga cga caa aga gag gct gag aca gat aac ctt gat cat tat act aat      243
 Arg Arg Gln Arg Glu Ala Glu Thr Asp Asn Leu Asp His Tyr Thr Asn
          60                  65                  70

 gcc tat gct gtg ttc tac aag gat gtc agg gct tat cga cag cta ttg      291
 Ala Tyr Ala Val Phe Tyr Lys Asp Val Arg Ala Tyr Arg Gln Leu Leu
      75                  80                  85

 gaa gaa tgt gat gtt ttt aac tgg gac caa gtt ttt caa ata caa ggg      339
 Glu Glu Cys Asp Val Phe Asn Trp Asp Gln Val Phe Gln Ile Gln Gly
  90                  95                 100                 105

 ctg cag agt gag tta tat gat gtt tcc aaa gcg gtt gcc aat tca aag      387
 Leu Gln Ser Glu Leu Tyr Asp Val Ser Lys Ala Val Ala Asn Ser Lys
                 110                 115                 120

 cag ttg aat ata aag cta act tcc ttc aag gct gtt cat ttt tct cct      435
 Gln Leu Asn Ile Lys Leu Thr Ser Phe Lys Ala Val His Phe Ser Pro
             125                 130                 135

 gtt tca tct ctg cca gat acc agt ttc ctg tat gta aac caa gtt ttt      483
 Val Ser Ser Leu Pro Asp Thr Ser Phe Leu Tyr Val Asn Gln Val Phe
         140                 145                 150

 gca ttt ggg gca gga ctt act gct ata gaa gta cac gta gca gta act      531
 Ala Phe Gly Ala Gly Leu Thr Ala Ile Glu Val His Val Ala Val Thr
     155                 160                 165

 ggg aca ctc agt gcc cag gat ttt att ggc agc atc ctc tgc cta gca      579
 Gly Thr Leu Ser Ala Gln Asp Phe Ile Gly Ser Ile Leu Cys Leu Ala
 170                 175                 180                 185

 cag act gat ttc cta gac tcg cag aag gaa agc caa tgt tca gca aaa      627
 Gln Thr Asp Phe Leu Asp Ser Gln Lys Glu Ser Gln Cys Ser Ala Lys
                 190                 195                 200

 ccc aca ctg ttt gca caa ctt aat cac agt gag cca ttt atc aag ggg      675
 Pro Thr Leu Phe Ala Gln Leu Asn His Ser Glu Pro Phe Ile Lys Gly
             205                 210                 215

 cct tcc cca cga cta acc tac ctg agt gtt gcc aat gcg gat cta ctc      723
 Pro Ser Pro Arg Leu Thr Tyr Leu Ser Val Ala Asn Ala Asp Leu Leu
         220                 225                 230

 aac cgg act tgg tcc cgg gga ggc aat gaa caa tgt ctc cgg tac atc      771
 Asn Arg Thr Trp Ser Arg Gly Gly Asn Glu Gln Cys Leu Arg Tyr Ile
     235                 240                 245

 gcc aac ctc atc tcc tgc ttc cct agt gtg tgt gtc cgg gat gag aag      819
 Ala Asn Leu Ile Ser Cys Phe Pro Ser Val Cys Val Arg Asp Glu Lys
 250                 255                 260                 265

 gga aac ccg gtc tcc tgg tcc atc aca gac cag ttt gcc acc atg tgc      867
 Gly Asn Pro Val Ser Trp Ser Ile Thr Asp Gln Phe Ala Thr Met Cys
                 270                 275                 280

 cat ggc tac acc ctg cca gaa cat cgc agg aaa ggt tac agc cgg ctg      915
 His Gly Tyr Thr Leu Pro Glu His Arg Arg Lys Gly Tyr Ser Arg Leu
             285                 290                 295

 gtg gcc ctc acg ctg gcc agg aag ttg caa agc cgg gga ttc ccc tct      963
 Val Ala Leu Thr Leu Ala Arg Lys Leu Gln Ser Arg Gly Phe Pro Ser
         300                 305                 310

 cag ggg aac gtc ctg gat gac aac acg gcg tct ata agc ctc ctg aag     1011
 Gln Gly Asn Val Leu Asp Asp Asn Thr Ala Ser Ile Ser Leu Leu Lys
     315                 320                 325

 agt ctc cat gct gag ttc ttg cct tgt cgc ttc cac agg ctt att ctc     1059
 Ser Leu His Ala Glu Phe Leu Pro Cys Arg Phe His Arg Leu Ile Leu
 330                 335                 340                 345

 acc cct gcg act ttc tct ggc ctg cct cac ctc tag                     1095
 Thr Pro Ala Thr Phe Ser Gly Leu Pro His Leu 
                 350                 355





      <210> 73
      <211> 593
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (120)..(389)

      <400> 73
 tccatccctc acactgtgcc catctttctg aagtaggaat ctgatcacac caccctgcta     60

 aaaacactct ggttctcccc acggcatgtg gtgcccttgt atagctggca aagccttgc     119                                                                 
 atg gca cgg ccc cag cct gtg ctt caa ctc aat tgc ccg act ctc tcc      167
 Met Ala Arg Pro Gln Pro Val Leu Gln Leu Asn Cys Pro Thr Leu Ser
   1               5                  10                  15

 agc tct gct gag cca cct aag tca cag atg gtt tct cct ctc atc tct      215
 Ser Ser Ala Glu Pro Pro Lys Ser Gln Met Val Ser Pro Leu Ile Ser
              20                  25                  30

 gct ctc ttc cat gtg cca ttt ctg tgg ctt gga atg ttc ttc cct cat      263
 Ala Leu Phe His Val Pro Phe Leu Trp Leu Gly Met Phe Phe Pro His
          35                  40                  45

 tct ctt tct ggc cct ttc ccg tca cac ctt aga cgt gca tct tcc tct      311
 Ser Leu Ser Gly Pro Phe Pro Ser His Leu Arg Arg Ala Ser Ser Ser
      50                  55                  60

 cga aaa cct cta gtg aag cct ccc agg gcc agg cag tac cct cct ctg      359
 Arg Lys Pro Leu Val Lys Pro Pro Arg Ala Arg Gln Tyr Pro Pro Leu
  65                  70                  75                  80

 ggt ttt ttt gga tac aaa aga aaa att tga g ccttgatttt ccatttcaac      410
 Gly Phe Phe Gly Tyr Lys Arg Lys Ile 
                  85

 aggcctttgt gtggctgctg actccggcta gaccaaagat ccgtaaggac agggatcgag    470

 tttttttttt tttaattccc tgcctcaaaa atcctttgtg cattacctat tcatcctttt    530

 ttttccccta acctgaacca gtgattttac cgtctccaac caaggttttt tcctttcctt    590

 tcc                                                                  593




      <210> 74
      <211> 2339
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (603)..(1394)

      <400> 74
 cgggtcgacg atttcgtcgc gccctcgccc ctcccgggcc tgcccccgtc gcgactggca     60

 gcacgaagct gagattgtgg tttcctggtg attcaggtgg gagtgggcca gaagatcacc    120

 gctggcaagg actggtgttt gtcaactgta aggactcatg gaacagatct accagggatt    180

 ctcagacctt agtttgagaa atgctgcaat taaaggcaaa tcctatcact ctgagtgatc    240

 gctttggtgt cgaggcaatc aaccataaag ataaatgcaa atatggaaat tgcataacag    300

 tactcagtat taaggttggt ttttggagta gtccctgctg acgtgacaaa aagatctctc    360

 atatgatatt ccgaggtatc tttgaggaag tctctctttg aggacctccc tttgagctga    420

 tggagaactg ggctccccac accctctctg tccccagctg agattatggt ggatttgggc    480

 tacggcccag gcctgggcct cctgctgctg acccagcccc agaggtgtta gcaagagccg    540

 tgtgctatcc accctccccg agaccacccc tccgaccagg ggcctggagc tggcgcgtga    600

 ct   atg cgg ctt ggg ctg tgt gtg gtg gcc ctg gtt ctg agc tgg acg     647
      Met Arg Leu Gly Leu Cys Val Val Ala Leu Val Leu Ser Trp Thr
        1               5                  10                  15

 cac ctc acc atc agc agc cgg ggg atc aag ggg aaa agg cag agg cgg      695
 His Leu Thr Ile Ser Ser Arg Gly Ile Lys Gly Lys Arg Gln Arg Arg
                  20                  25                  30

 atc agt gcc gag ggg agc cag gcc tgt gcc aaa ggc tgt gag ctc tgc      743
 Ile Ser Ala Glu Gly Ser Gln Ala Cys Ala Lys Gly Cys Glu Leu Cys
              35                  40                  45

 tct gaa gtc aac ggc tgc ctc aag tgc tca ccc aag ctg ttc atc ctg      791
 Ser Glu Val Asn Gly Cys Leu Lys Cys Ser Pro Lys Leu Phe Ile Leu
          50                  55                  60

 ctg gag agg aac gac atc cgc cag gtg ggc gtc tgc ttg ccg tcc tgc      839
 Leu Glu Arg Asn Asp Ile Arg Gln Val Gly Val Cys Leu Pro Ser Cys
      65                  70                  75

 cca cct gga tac ttc gac gcc cgc aac ccc gac atg aac aag tgc atc      887
 Pro Pro Gly Tyr Phe Asp Ala Arg Asn Pro Asp Met Asn Lys Cys Ile
  80                  85                  90                  95

 aaa tgc aag atc gag cac tgt gag gcc tgc ttc agc cat aac ttc tgc      935
 Lys Cys Lys Ile Glu His Cys Glu Ala Cys Phe Ser His Asn Phe Cys
                 100                 105                 110

 acc aag tgt aag gag ggc ttg tac ctg cac aag ggc cgc tgc tat cca      983
 Thr Lys Cys Lys Glu Gly Leu Tyr Leu His Lys Gly Arg Cys Tyr Pro
             115                 120                 125

 gct tgt ccc gag ggc tcc tca gct gcc aat ggc acc atg gag tgc agt     1031
 Ala Cys Pro Glu Gly Ser Ser Ala Ala Asn Gly Thr Met Glu Cys Ser
         130                 135                 140

 agt cct gcg caa tgt gaa atg agc gag tgg tct ccg tgg ggg ccc tgc     1079
 Ser Pro Ala Gln Cys Glu Met Ser Glu Trp Ser Pro Trp Gly Pro Cys
     145                 150                 155

 tcc aag aag cag cag ctc tgt ggt ttc cgg agg ggc tcc gag gag cgg     1127
 Ser Lys Lys Gln Gln Leu Cys Gly Phe Arg Arg Gly Ser Glu Glu Arg
 160                 165                 170                 175

 aca cgc agg gtg cta cat gcc cct gtg ggg gac cat gct gcc tgc tct     1175
 Thr Arg Arg Val Leu His Ala Pro Val Gly Asp His Ala Ala Cys Ser
                 180                 185                 190

 gac acc aag gag acc cgg agg tgc aca gtg agg aga gtg ccg tgt cct     1223
 Asp Thr Lys Glu Thr Arg Arg Cys Thr Val Arg Arg Val Pro Cys Pro
             195                 200                 205

 gag ggg cag aag agg agg aag gga ggc cag ggc cgg cgg gag aat gcc     1271
 Glu Gly Gln Lys Arg Arg Lys Gly Gly Gln Gly Arg Arg Glu Asn Ala
         210                 215                 220

 aac agg aac ctg gcc agg aag gag agc aag gag gcg ggt gct ggc tct     1319
 Asn Arg Asn Leu Ala Arg Lys Glu Ser Lys Glu Ala Gly Ala Gly Ser
     225                 230                 235

 cga aga cgc aag ggg cag caa cag cag cag cag caa ggg aca gtg ggg     1367
 Arg Arg Arg Lys Gly Gln Gln Gln Gln Gln Gln Gln Gly Thr Val Gly
 240                 245                 250                 255

 cca ctc aca tct gca ggg cct gcc tag ggaca ctgtccagcc tccaggccca     1419
 Pro Leu Thr Ser Ala Gly Pro Ala 
                 260

 tgcagaaaga gttcagtgct actctgcgtg attcaagctt tcctgaactg gaacgtcggg   1479

 ggcaaagcat acacacacac tccaatccat ccatgcatac acagacacaa gacacacacg   1539

 ctcaaacccc tgtccacata tacaaccata catacttgca catgtgtgtt catgtacaca   1599

 cgcagacaca gacaccacac acacacatac acacacacac acacacgcac acctgaggcc   1659

 accagaagac acttccatcc ctcgggccca gcagtacaca cttggtttcc agagctccca   1719

 gtggacatgt cagagacaac acttcccagc atctgagacc aaactgcaga ggggagcctt   1779

 ctggagaagc tgctgggatc ggaccagcca ctgtggcaga tgggagccaa gcttgaggac   1839

 tgctggtggc ctgggaagaa accttcttcc catcctgttc agcactccca gctgtgtgac   1899

 tttatcgttg gagagtattg ttaccttcca ggatacatat cagggttaac ctgactttga   1959

 aaactgctta aaggtttatt tcaaattaaa acaaaaaaat caacgacagc agtagacaca   2019

 ggcaccacat tcctttgcag ggtgtgaggg tttggcgagg tatgcgtagg agcaagaagg   2079

 gacagggaat ttcaagagac cccaaatagc ctgctcagta gagggtcatg cagacaagga   2139

 agaaaactta ggggctgctc tgacggtggt aaacaggctg tctatatcct tgttactcag   2199

 agcatggccc ggcagcagtg ttgtcacagg gcagcttgtt aggaatgata atctcaggtc   2259

 tcattccaga cctggagagc catgagtcta aattttaaga ttcctgatga ttggcatgtt   2319

 acccaaattt gagaagtgct                                               2339




      <210> 75
      <211> 686
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (355)..(519)

      <400> 75
 cgacgattcc gctgagcctc tgcccttctc tttgttgttg gttctgcaaa gtcattaagg     60

 gagtttactg cagactgtcc cccatataag tgtcctgtgg cccctgagcc tttgcctcag    120

 cctctctctc tccctgcagt gccctgggag gaatcaactg acagcccttt cagtctccca    180

 cagtccagcc agttaaatca aggtgttccc cttttataga ggagtctcct agagccaacc    240

 gcagcatccc tgcctttggg agccacctgg aatgtgccag ctgcagtagc cgttccttcc    300

 acgccccccc cccatgctgt ctgtggggct tgccactgag tgctccatct cccc  atg     357
                                                              Met
                                                                1

 tgc tcc atc ccc cgg cat ctg ctg cca ttg gtc ctg cct gtt gcg tta      405
 Cys Ser Ile Pro Arg His Leu Leu Pro Leu Val Leu Pro Val Ala Leu
               5                  10                  15

 ctt ctc tgt gcc ctg gag ccc ctc aag cac aga ggc ctc gaa agg ttg      453
 Leu Leu Cys Ala Leu Glu Pro Leu Lys His Arg Gly Leu Glu Arg Leu
          20                  25                  30

 atc aga cat cct cag cac ctg gag cgg ggc ctg gca cac aag acg gca      501
 Ile Arg His Pro Gln His Leu Glu Arg Gly Leu Ala His Lys Thr Ala
      35                  40                  45

 atg aac ggc caa ccc tag aagttc accccacaag acctgcaggg cgggggctga      555
 Met Asn Gly Gln Pro 
  50

 gtgtccaaga agcctcttgg gaagggatgg tcttagacct agtggtgtct tcccattctg    615

 cagaggccta gggatgtccc caggtcccca gagtgggagg ggaagggtca gaagtccatg    675

 gaaataaaac a                                                         686




      <210> 76
      <211> 1745
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (1)..(1335)

      <400> 76
  atg cca ctg aag cat tat ctc ctt ttg ctg gtg ggc tgc caa gcc tgg      48
  Met Pro Leu Lys His Tyr Leu Leu Leu Leu Val Gly Cys Gln Ala Trp
    1               5                  10                  15

 ggt gca ggg ttg gcc tac cat ggc tgc cct agc gag tgt acc tgc tcc       96
 Gly Ala Gly Leu Ala Tyr His Gly Cys Pro Ser Glu Cys Thr Cys Ser
              20                  25                  30

 agg gcc tcc cag gtg gag tgc acc ggg gca cgc att gtg gca gtg ccc      144
 Arg Ala Ser Gln Val Glu Cys Thr Gly Ala Arg Ile Val Ala Val Pro
          35                  40                  45

 acc cct ctg ccc tgg aac gcc atg agc ctg cag atc ctc aac acg cac      192
 Thr Pro Leu Pro Trp Asn Ala Met Ser Leu Gln Ile Leu Asn Thr His
      50                  55                  60

 atc act gaa ctc aat gag tcc ccg ttc ctc aat atc tca gcc ctc atc      240
 Ile Thr Glu Leu Asn Glu Ser Pro Phe Leu Asn Ile Ser Ala Leu Ile
  65                  70                  75                  80

 gcc ctg agg att gag aag aat gag ctg tcg cgc atc acg cct ggg gcc      288
 Ala Leu Arg Ile Glu Lys Asn Glu Leu Ser Arg Ile Thr Pro Gly Ala
                  85                  90                  95

 ttc cga aac ctg ggc tcg ctg cgc tat ctc agc ctc gcc aac aac aag      336
 Phe Arg Asn Leu Gly Ser Leu Arg Tyr Leu Ser Leu Ala Asn Asn Lys
             100                 105                 110

 ctg cag gtt ctg ccc atc ggc ctc ttc cag ggc ctg gac agc ctt gag      384
 Leu Gln Val Leu Pro Ile Gly Leu Phe Gln Gly Leu Asp Ser Leu Glu
         115                 120                 125

 tct ctc ctt ctg tcc agt aac cag ctg ttg cag atc cag ccg gcc cac      432
 Ser Leu Leu Leu Ser Ser Asn Gln Leu Leu Gln Ile Gln Pro Ala His
     130                 135                 140

 ttc tcc cag tgc agc aac ctc aag gag ctg cag ttg cac ggc aac cac      480
 Phe Ser Gln Cys Ser Asn Leu Lys Glu Leu Gln Leu His Gly Asn His
 145                 150                 155                 160

 ctg gaa tac atc cct gac gga gcc ttc gac cac ctg gta gga ctc acg      528
 Leu Glu Tyr Ile Pro Asp Gly Ala Phe Asp His Leu Val Gly Leu Thr
                 165                 170                 175

 aag ctc aat ctg ggc aag aat agc ctc acc cac atc tca ccc agg gtc      576
 Lys Leu Asn Leu Gly Lys Asn Ser Leu Thr His Ile Ser Pro Arg Val
             180                 185                 190

 ttc cag cac ctg ggc aat ctc cag gtc ctc cgg ctg tat gag aac agg      624
 Phe Gln His Leu Gly Asn Leu Gln Val Leu Arg Leu Tyr Glu Asn Arg
         195                 200                 205

 ctc acg gat atc ccc atg ggc act ttt gat ggg ctt gtt aac ctg cag      672
 Leu Thr Asp Ile Pro Met Gly Thr Phe Asp Gly Leu Val Asn Leu Gln
     210                 215                 220

 gaa ctg gct cta cag cag aac cag att gga ctg ctc tcc cct ggt ctc      720
 Glu Leu Ala Leu Gln Gln Asn Gln Ile Gly Leu Leu Ser Pro Gly Leu
 225                 230                 235                 240

 ttc cac aac aac cac aac ctc cag aga ctc tac ctg tcc aac aac cac      768
 Phe His Asn Asn His Asn Leu Gln Arg Leu Tyr Leu Ser Asn Asn His
                 245                 250                 255

 atc tcc cag ctg cca ccc agc atc ttc atg cag ctg ccc cag ctc aac      816
 Ile Ser Gln Leu Pro Pro Ser Ile Phe Met Gln Leu Pro Gln Leu Asn
             260                 265                 270

 cgt ctt act ctc ttt ggg aat tcc ctg aag gag ctc tct ctg ggg atc      864
 Arg Leu Thr Leu Phe Gly Asn Ser Leu Lys Glu Leu Ser Leu Gly Ile
         275                 280                 285

 ttc ggg ccc atg ccc aac ctg cgg gag ctt tgg ctc tat gac aac cac      912
 Phe Gly Pro Met Pro Asn Leu Arg Glu Leu Trp Leu Tyr Asp Asn His
     290                 295                 300

 atc tct tct cta ccc gac aat gtc ttc agc aac ctc cgc cag ttg cag      960
 Ile Ser Ser Leu Pro Asp Asn Val Phe Ser Asn Leu Arg Gln Leu Gln
 305                 310                 315                 320

 gtc ctg att ctt agc cgc aat cag atc agc ttc atc tcc ccg ggt gcc     1008
 Val Leu Ile Leu Ser Arg Asn Gln Ile Ser Phe Ile Ser Pro Gly Ala
                 325                 330                 335

 ttc aac ggg cta acg gag ctt cgg gag ctg tcc ctc cac acc aac gca     1056
 Phe Asn Gly Leu Thr Glu Leu Arg Glu Leu Ser Leu His Thr Asn Ala
             340                 345                 350

 ctg cag gac ctg gac ggg aat gtc ttc cgc atg ttg gcc aac ctg cag     1104
 Leu Gln Asp Leu Asp Gly Asn Val Phe Arg Met Leu Ala Asn Leu Gln
         355                 360                 365

 aca tct ccc tgc aga aca atc gcc tca gac agc tcc cag gga ata tct     1152
 Thr Ser Pro Cys Arg Thr Ile Ala Ser Asp Ser Ser Gln Gly Ile Ser
     370                 375                 380

 tcg cca acg tca atg gcc tca tgg cca tcc agc tgc aga aca acc agc     1200
 Ser Pro Thr Ser Met Ala Ser Trp Pro Ser Ser Cys Arg Thr Thr Ser
 385                 390                 395                 400

 tgg aga act tgc ccc tcg gca tct tcg atc acc tgg gga aac tgt gtg     1248
 Trp Arg Thr Cys Pro Ser Ala Ser Ser Ile Thr Trp Gly Asn Cys Val
                 405                 410                 415

 agc tgc ggc tgt atg aca atc cct gga ggt gtg act cag aca tcc ttc     1296
 Ser Cys Gly Cys Met Thr Ile Pro Gly Gly Val Thr Gln Thr Ser Phe
             420                 425                 430

 cgc tcc gca act ggc tcc tgc tca acc agc cta ggt tag ggacggacac      1345
 Arg Ser Ala Thr Gly Ser Cys Ser Thr Ser Leu Gly 
         435                 440

 tgtacctgtg tgtttcagcc cagccaatgt ccgaggccag tccctcatta tcatcaatgt   1405

 caacgttgct gttccaagcg tccatgtacc tgaggtgcct agttacccag aaacaccatg   1465

 gtacccagac acacccagtt accctgacac cacatccgtc tcttctacca ctgagctaac   1525

 cagccctgtg gaagactaca ctgatctgac taccattcag gtcactgatg accgcagcgt   1585

 ttggggcatg acccatgccc atagcgggct ggccattgcc gccattgtaa ttggcattgt   1645

 cgccctggcc tgctccctgg ctgcctgcgt cggctgttgc tgctgcaaga agaggagcca   1705

 agctgtcctg atgcagatga aggcacccaa tgagtgttaa                         1745




      <210> 77
      <211> 1080
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (1)..(1080)

      <400> 77
  atg gag gcg gcg gcc gga gtg tgg ggc tgg ggc tgc ctt ttc cgc gtc      48
  Met Glu Ala Ala Ala Gly Val Trp Gly Trp Gly Cys Leu Phe Arg Val
    1               5                  10                  15

 ccc tgg agg aga cct cag gca gcc tct gta ggt ctg agg acc cgc ctg       96
 Pro Trp Arg Arg Pro Gln Ala Ala Ser Val Gly Leu Arg Thr Arg Leu
              20                  25                  30

 cat gcc agg ttc tcc ggg agg ctt tgg act tgg gag cct ttg aac gtg      144
 His Ala Arg Phe Ser Gly Arg Leu Trp Thr Trp Glu Pro Leu Asn Val
          35                  40                  45

 ccc ttg aga ggc gga tca gaa ggg ggc agg ttt tac gca tca tgt gtt      192
 Pro Leu Arg Gly Gly Ser Glu Gly Gly Arg Phe Tyr Ala Ser Cys Val
      50                  55                  60

 gag ccc ctc aca tgc acc ctc caa gga cct gtc ggg gat gga gca gct      240
 Glu Pro Leu Thr Cys Thr Leu Gln Gly Pro Val Gly Asp Gly Ala Ala
  65                  70                  75                  80

 tgc tgg aga caa ggg gca tgg cct cag cgg tgg cgc cgg gag cct gga      288
 Cys Trp Arg Gln Gly Ala Trp Pro Gln Arg Trp Arg Arg Glu Pro Gly
                  85                  90                  95

 aac ctg gcc ggc gtc agg cac atc atc ctg gtc ctc tca gga aag ggg      336
 Asn Leu Ala Gly Val Arg His Ile Ile Leu Val Leu Ser Gly Lys Gly
             100                 105                 110

 ggc gtt ggg aaa agc acc atc tcc acg gag ctg gcc ctg gca ctg cgc      384
 Gly Val Gly Lys Ser Thr Ile Ser Thr Glu Leu Ala Leu Ala Leu Arg
         115                 120                 125

 cat gca ggc aag aag gtg gga atc ctg gat gtg gac ctg tgt ggc ccc      432
 His Ala Gly Lys Lys Val Gly Ile Leu Asp Val Asp Leu Cys Gly Pro
     130                 135                 140

 agt ata ccc cgc atg ctc ggg gcg cag ggc agg gct gtg cac cag tgc      480
 Ser Ile Pro Arg Met Leu Gly Ala Gln Gly Arg Ala Val His Gln Cys
 145                 150                 155                 160

 gac cgc ggc tgg gca ccc gtc ttc ctg gac cgg gag cag agc atc tcg      528
 Asp Arg Gly Trp Ala Pro Val Phe Leu Asp Arg Glu Gln Ser Ile Ser
                 165                 170                 175

 ctc atg tct gtg ggc ttc ctg ctg gag aag ccg gac gag gcc gtg gtg      576
 Leu Met Ser Val Gly Phe Leu Leu Glu Lys Pro Asp Glu Ala Val Val
             180                 185                 190

 tgg aga ggc ccc aag aaa aac gcg ctg ata aag cag ttt gtg tcc gac      624
 Trp Arg Gly Pro Lys Lys Asn Ala Leu Ile Lys Gln Phe Val Ser Asp
         195                 200                 205

 gtg gcc tgg ggg gag ctg gac tac ctg gtg gtg gac acg ccc ccg ggg      672
 Val Ala Trp Gly Glu Leu Asp Tyr Leu Val Val Asp Thr Pro Pro Gly
     210                 215                 220

 acc tcc gat gag cac atg gcc acc ata gaa gcc ctg cgt ccc tac cag      720
 Thr Ser Asp Glu His Met Ala Thr Ile Glu Ala Leu Arg Pro Tyr Gln
 225                 230                 235                 240

 ccc ctg ggg gcc ctc gtg gtc acc acg ccc cag gcg gtg tcc gtg ggg      768
 Pro Leu Gly Ala Leu Val Val Thr Thr Pro Gln Ala Val Ser Val Gly
                 245                 250                 255

 gac gtg agg cgc gag ctg acc ttc tgt agg aag acg ggc ttg cgg gtg      816
 Asp Val Arg Arg Glu Leu Thr Phe Cys Arg Lys Thr Gly Leu Arg Val
             260                 265                 270

 atg gga atc gtg gag aat atg agc ggc ttc acc tgc cca cac tgc acg      864
 Met Gly Ile Val Glu Asn Met Ser Gly Phe Thr Cys Pro His Cys Thr
         275                 280                 285

 gag tgc acc agc gtc ttc tcc agg ggc ggc gga gag gag ctg gcc cag      912
 Glu Cys Thr Ser Val Phe Ser Arg Gly Gly Gly Glu Glu Leu Ala Gln
     290                 295                 300

 ctc gcc ggg gtg ccc ttc tta ggc tcc gtg ccc ctg gac cct gcg ctc      960
 Leu Ala Gly Val Pro Phe Leu Gly Ser Val Pro Leu Asp Pro Ala Leu
 305                 310                 315                 320

 atg agg acc ctg gag gag ggc cac gac ttc atc cag gag ttc ccc ggg     1008
 Met Arg Thr Leu Glu Glu Gly His Asp Phe Ile Gln Glu Phe Pro Gly
                 325                 330                 335

 agc ccc gcc ttc gct gca ctc acc tcc ata gcc cag aag att ctg gac     1056
 Ser Pro Ala Phe Ala Ala Leu Thr Ser Ile Ala Gln Lys Ile Leu Asp
             340                 345                 350

 gcg acg ccc gcg tgc ctc ccc tga                                     1080
 Ala Thr Pro Ala Cys Leu Pro 
         355





      <210> 78
      <211> 2534
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (374)..(2431)

      <400> 78
 ggacagtgga gacgcgcctt ctcggctctg gtccgcgccc tggggccctg gctccctgga     60

 ggggctgggg aactggaagc tgggccgaga gagttcccgc tgcagctatc gcgcagtccc    120

 tcctgcgccc gggcgccccc agcgggttcc gggaggcgcc cggtgagccc acgtctgttg    180

 cggcggagcg agcgcgctcc gggagggccg agagccggcg gggctggcag gagctctcgg    240

 gcgcccgcct ccctccttcg cggacggtct cccgacacgc cggctgagag cccttttcga    300

 ctgtgagctg cggcagctga gcagaggcgg cggcgcggga cctgcagtcg ccagggattc    360

 cctccaggtg acg   atg ctc tgg ttc tcc ggc gtc ggg gct ctg gct gag     409
                  Met Leu Trp Phe Ser Gly Val Gly Ala Leu Ala Glu
                    1               5                  10

 cgt tac tgc cgc cgc tcg cct ggg att acg tgc tgc gtc ttg ctg cta      457
 Arg Tyr Cys Arg Arg Ser Pro Gly Ile Thr Cys Cys Val Leu Leu Leu
          15                  20                  25

 ctc aat tgc tcg ggg gtc ccc atg tct ctg gct tcc tcc ttc ttg aca      505
 Leu Asn Cys Ser Gly Val Pro Met Ser Leu Ala Ser Ser Phe Leu Thr
      30                  35                  40

 ggt tct gtt gca aaa tgt gaa aat gaa ggt gaa gtc ctc cag att cca      553
 Gly Ser Val Ala Lys Cys Glu Asn Glu Gly Glu Val Leu Gln Ile Pro
  45                  50                  55                  60

 ttt atc aca gac aac cct tgc ata atg tgt gtc tgc ttg aac aag gaa      601
 Phe Ile Thr Asp Asn Pro Cys Ile Met Cys Val Cys Leu Asn Lys Glu
                  65                  70                  75

 gtg aca tgt aag aga gag aag tgc ccc gtg ctg tcc cga gac tgt gcc      649
 Val Thr Cys Lys Arg Glu Lys Cys Pro Val Leu Ser Arg Asp Cys Ala
              80                  85                  90

 ctg gcc atc aag cag agg gga gcc tgt tgt gaa cag tgc aaa ggt tgc      697
 Leu Ala Ile Lys Gln Arg Gly Ala Cys Cys Glu Gln Cys Lys Gly Cys
          95                 100                 105

 acc tat gaa gga aat acc tat aac agc tcc ttc aaa tgg cag agc ccg      745
 Thr Tyr Glu Gly Asn Thr Tyr Asn Ser Ser Phe Lys Trp Gln Ser Pro
     110                 115                 120

 gct gag cct tgt gtt cta cgc cag tgc cag gag ggc gtt gtc aca gag      793
 Ala Glu Pro Cys Val Leu Arg Gln Cys Gln Glu Gly Val Val Thr Glu
 125                 130                 135                 140

 tct ggg gtg cgc tgt gtt gtt cat tgt aaa aac cct ttg gag cat ctg      841
 Ser Gly Val Arg Cys Val Val His Cys Lys Asn Pro Leu Glu His Leu
                 145                 150                 155

 gga atg tgc tgc ccc aca tgt cca ggc tgt gtg ttt gag ggt gtg cag      889
 Gly Met Cys Cys Pro Thr Cys Pro Gly Cys Val Phe Glu Gly Val Gln
             160                 165                 170

 tat caa gaa ggg gag gaa ttt cag cca gaa gga agc aaa tgt acc aag      937
 Tyr Gln Glu Gly Glu Glu Phe Gln Pro Glu Gly Ser Lys Cys Thr Lys
         175                 180                 185

 tgt tcc tgc act gga ggc agg aca caa tgt gtg aga gaa gtc tgt ccc      985
 Cys Ser Cys Thr Gly Gly Arg Thr Gln Cys Val Arg Glu Val Cys Pro
     190                 195                 200

 att ctc tcc tgt ccc cag cac ctt agt cac ata ccc cca gga cag tgc     1033
 Ile Leu Ser Cys Pro Gln His Leu Ser His Ile Pro Pro Gly Gln Cys
 205                 210                 215                 220

 tgc ccc aaa tgt ttg ggt cag agg aaa gtg ttt gac ctc cct ttt ggg     1081
 Cys Pro Lys Cys Leu Gly Gln Arg Lys Val Phe Asp Leu Pro Phe Gly
                 225                 230                 235

 agc tgc ctc ttt cga agt gat gtt tat gac aat gga tcc tca ttt ctg     1129
 Ser Cys Leu Phe Arg Ser Asp Val Tyr Asp Asn Gly Ser Ser Phe Leu
             240                 245                 250

 tac gat aac tgc aca gct tgt acc tgc agg gac tct act gtg gtt tgc     1177
 Tyr Asp Asn Cys Thr Ala Cys Thr Cys Arg Asp Ser Thr Val Val Cys
         255                 260                 265

 aag agg aag tgc tcc cac cct ggt ggc tgt gac caa ggc cag gag ggc     1225
 Lys Arg Lys Cys Ser His Pro Gly Gly Cys Asp Gln Gly Gln Glu Gly
     270                 275                 280

 tgt tgt gaa gag tgc ctc cta cga gtg ccc cca gaa gac atc aaa gta     1273
 Cys Cys Glu Glu Cys Leu Leu Arg Val Pro Pro Glu Asp Ile Lys Val
 285                 290                 295                 300

 tgc aaa ttt ggc aac aag att ttc cag gat gga gag atg tgg tcc tct     1321
 Cys Lys Phe Gly Asn Lys Ile Phe Gln Asp Gly Glu Met Trp Ser Ser
                 305                 310                 315

 atc aat tgt acc atc tgt gct tgt gtg aaa ggc agg acg gag tgt cgc     1369
 Ile Asn Cys Thr Ile Cys Ala Cys Val Lys Gly Arg Thr Glu Cys Arg
             320                 325                 330

 aat aag cag tgc att ccc atc agt agc tgc cca cag ggc aaa att ctc     1417
 Asn Lys Gln Cys Ile Pro Ile Ser Ser Cys Pro Gln Gly Lys Ile Leu
         335                 340                 345

 aac aga aaa gga tgc tgt cct att tgc act gaa aag ccc ggc gtt tgc     1465
 Asn Arg Lys Gly Cys Cys Pro Ile Cys Thr Glu Lys Pro Gly Val Cys
     350                 355                 360

 acg gtg ttt gga gat ccc cac tac aac act ttt gac ggt cgg aca ttt     1513
 Thr Val Phe Gly Asp Pro His Tyr Asn Thr Phe Asp Gly Arg Thr Phe
 365                 370                 375                 380

 aac ttt cag ggg acg tgt cag tac gtt ttg aca aaa gac tgc tcc tcc     1561
 Asn Phe Gln Gly Thr Cys Gln Tyr Val Leu Thr Lys Asp Cys Ser Ser
                 385                 390                 395

 cct gcc tcg ccc ttc cag gtg ctg gtg aag aac gac gcc cgc cgg aca     1609
 Pro Ala Ser Pro Phe Gln Val Leu Val Lys Asn Asp Ala Arg Arg Thr
             400                 405                 410

 cgc tcc ttc tcg tgg acc aag tcg gtg gag ctg gtg ctg ggc gag agc     1657
 Arg Ser Phe Ser Trp Thr Lys Ser Val Glu Leu Val Leu Gly Glu Ser
         415                 420                 425

 agg gtc agc ctg cag cag cac ctc acc gtg cgc tgg aac ggc tcg cgc     1705
 Arg Val Ser Leu Gln Gln His Leu Thr Val Arg Trp Asn Gly Ser Arg
     430                 435                 440

 atc gcg ctc ccc tgc cgc gcg cca cac ttc cac atc gac ctg gat ggc     1753
 Ile Ala Leu Pro Cys Arg Ala Pro His Phe His Ile Asp Leu Asp Gly
 445                 450                 455                 460

 tac ctc ttg aaa gtg acc acc aaa gca ggt ttg gaa ata tct tgg gat     1801
 Tyr Leu Leu Lys Val Thr Thr Lys Ala Gly Leu Glu Ile Ser Trp Asp
                 465                 470                 475

 gga gac agt ttt gta gaa gtc atg gct gcg ccg cat ctc aag ggc aag     1849
 Gly Asp Ser Phe Val Glu Val Met Ala Ala Pro His Leu Lys Gly Lys
             480                 485                 490

 ctc tgt ggt ctt tgt ggc aac tac aat gga cat aaa cgt gat gac tta     1897
 Leu Cys Gly Leu Cys Gly Asn Tyr Asn Gly His Lys Arg Asp Asp Leu
         495                 500                 505

 att ggt gga gat gga aac ttc aag ttt gat gtg gat gac ttt gct gaa     1945
 Ile Gly Gly Asp Gly Asn Phe Lys Phe Asp Val Asp Asp Phe Ala Glu
     510                 515                 520

 tct tgg agg gtg gag tcc aat gag ttc tgc aac aga cct cag aga aag     1993
 Ser Trp Arg Val Glu Ser Asn Glu Phe Cys Asn Arg Pro Gln Arg Lys
 525                 530                 535                 540

 cca gtg cct gaa ctg tgt caa ggg aca gtc aag gta aag ctc cgg gcc     2041
 Pro Val Pro Glu Leu Cys Gln Gly Thr Val Lys Val Lys Leu Arg Ala
                 545                 550                 555

 cat cga gaa tgc caa aag ctc aaa tcc tgg gag ttt cag acc tgc cac     2089
 His Arg Glu Cys Gln Lys Leu Lys Ser Trp Glu Phe Gln Thr Cys His
             560                 565                 570

 tcg act gtg gac tac gcc act ttc tac cgg tcc tgt gtg aca gac atg     2137
 Ser Thr Val Asp Tyr Ala Thr Phe Tyr Arg Ser Cys Val Thr Asp Met
         575                 580                 585

 tgt gaa tgt cca gtc cat aaa aac tgt tat tgc gag tca ttt ttg gca     2185
 Cys Glu Cys Pro Val His Lys Asn Cys Tyr Cys Glu Ser Phe Leu Ala
     590                 595                 600

 tat acc cgg gcc tgc cag aga gag ggc atc aaa gtc cac tgg gag cct     2233
 Tyr Thr Arg Ala Cys Gln Arg Glu Gly Ile Lys Val His Trp Glu Pro
 605                 610                 615                 620

 cag cag aat tgt gca gcc acc cag tgt aag cat ggt gct gtg tac gat     2281
 Gln Gln Asn Cys Ala Ala Thr Gln Cys Lys His Gly Ala Val Tyr Asp
                 625                 630                 635

 acc tgt ggt ccg gga tgt atc aag acc tgt gac aac tgg aat gaa att     2329
 Thr Cys Gly Pro Gly Cys Ile Lys Thr Cys Asp Asn Trp Asn Glu Ile
             640                 645                 650

 ggt cca tgc aac aag ccg tgc gtt gct ggg tgc cac tgt cca gca aac     2377
 Gly Pro Cys Asn Lys Pro Cys Val Ala Gly Cys His Cys Pro Ala Asn
         655                 660                 665

 ttg gtc ctt cac aag gga agg tgc atc aag cca gtc ctt tgt ccc cag     2425
 Leu Val Leu His Lys Gly Arg Cys Ile Lys Pro Val Leu Cys Pro Gln
     670                 675                 680

 cgg tga cctttgtttc gatccttaag actctgaaat ctggtgactt tgacactgaa      2481
 Arg 
 685

 gcggaagagc caatgaaggg ctgcagtatt tgtgtgcccg attctgtaaa cac          2534




      <210> 79
      <211> 975
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (1)..(975)

      <400> 79
  atg cag ctc cca ctg gcc ctg tgt ctc gtc tgc ctg ctg gta cac aca      48
  Met Gln Leu Pro Leu Ala Leu Cys Leu Val Cys Leu Leu Val His Thr
    1               5                  10                  15

 gcc ttc cgt gta gtg gag ggc cag ggg tgg cag gcg ttc aag aat gat       96
 Ala Phe Arg Val Val Glu Gly Gln Gly Trp Gln Ala Phe Lys Asn Asp
              20                  25                  30

 gcc acg gaa atc atc ccc gag ctc gga gag tac ccc gag cct cca ccg      144
 Ala Thr Glu Ile Ile Pro Glu Leu Gly Glu Tyr Pro Glu Pro Pro Pro
          35                  40                  45

 gag ctg gag aac aac aag acc atg aac cgg gcg gag aac gga ggg cgg      192
 Glu Leu Glu Asn Asn Lys Thr Met Asn Arg Ala Glu Asn Gly Gly Arg
      50                  55                  60

 cct ccc cac cac ccc ttt gag acc aaa gca ctg gtc gag gaa cag tct      240
 Pro Pro His His Pro Phe Glu Thr Lys Ala Leu Val Glu Glu Gln Ser
  65                  70                  75                  80

 tgc ctg gag gtg ggg gaa gaa tgg ctc gct ggt gca gcc ttc aaa ttc      288
 Cys Leu Glu Val Gly Glu Glu Trp Leu Ala Gly Ala Ala Phe Lys Phe
                  85                  90                  95

 agg tgc aga ggc atg agg caa cag acg ctg gtg aga gcc cag ggc agg      336
 Arg Cys Arg Gly Met Arg Gln Gln Thr Leu Val Arg Ala Gln Gly Arg
             100                 105                 110

 gag gac gct ggg gtg gtg agg gta tgg cat cag ggc atc aga aca ggc      384
 Glu Asp Ala Gly Val Val Arg Val Trp His Gln Gly Ile Arg Thr Gly
         115                 120                 125

 tca ggg gct cag aaa aga aaa ggt ttc aaa gaa tct cct cct ggg aat      432
 Ser Gly Ala Gln Lys Arg Lys Gly Phe Lys Glu Ser Pro Pro Gly Asn
     130                 135                 140

 ata gga gcc acg tcc agc tgc tgg tac cac tgg gaa ggg aac aag gtg      480
 Ile Gly Ala Thr Ser Ser Cys Trp Tyr His Trp Glu Gly Asn Lys Val
 145                 150                 155                 160

 gca gag aag tcc act gcc cag gct cct gga ccc cag ccc tcc ccg cct      528
 Ala Glu Lys Ser Thr Ala Gln Ala Pro Gly Pro Gln Pro Ser Pro Pro
                 165                 170                 175

 cac aac ctg ttg gga cta tgg ggt gct aaa aag ggc aac tgc atg gga      576
 His Asn Leu Leu Gly Leu Trp Gly Ala Lys Lys Gly Asn Cys Met Gly
             180                 185                 190

 ggc cag cca gga ccc tcc gtc ttc aaa atg gag gac aag ggc gcc tcc      624
 Gly Gln Pro Gly Pro Ser Val Phe Lys Met Glu Asp Lys Gly Ala Ser
         195                 200                 205

 ccc cac agc tcc cct tct agg caa ggt cag ctg ggc tcc agc gac tgc      672
 Pro His Ser Ser Pro Ser Arg Gln Gly Gln Leu Gly Ser Ser Asp Cys
     210                 215                 220

 ctg aag ggc tac gtg tcc gag tac agc tgc cgc gag ctg cac ttc acc      720
 Leu Lys Gly Tyr Val Ser Glu Tyr Ser Cys Arg Glu Leu His Phe Thr
 225                 230                 235                 240

 cgc tac gtg acc gat ggg ccg tgc cgc agc gcc aag ccg gtc acc gag      768
 Arg Tyr Val Thr Asp Gly Pro Cys Arg Ser Ala Lys Pro Val Thr Glu
                 245                 250                 255

 ctg gtg tgc tcc ggc cag tgc ggc ccg gcg cgc ctg ctg ccc aac gcc      816
 Leu Val Cys Ser Gly Gln Cys Gly Pro Ala Arg Leu Leu Pro Asn Ala
             260                 265                 270

 atc ggc cgc ggc aag tgg tgg cga cct agt ggg ccc gac ttc cgc tgc      864
 Ile Gly Arg Gly Lys Trp Trp Arg Pro Ser Gly Pro Asp Phe Arg Cys
         275                 280                 285

 atc ccc gac cgc tac cgg cgc gtg cag ctg ctg tgt ccc ggt gaa ggg      912
 Ile Pro Asp Arg Tyr Arg Arg Val Gln Leu Leu Cys Pro Gly Glu Gly
     290                 295                 300

 cgg aag cgc ggc ccg gcc cgg agc gcc aaa gcc aac cag gcc gag ctg      960
 Arg Lys Arg Gly Pro Ala Arg Ser Ala Lys Ala Asn Gln Ala Glu Leu
 305                 310                 315                 320

 gag aac gcc tac tag                                                  975
 Glu Asn Ala Tyr 






      <210> 80
      <211> 828
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (521)..(760)

      <400> 80
 atactggagc tcttttgtgt gtgtgtgcac ttttgttaag agggagaaag ggcaccaatc     60

 agagccagaa agatttgcat ctcgatgtat tgttaaaatg cttttatttt atgtaaatag    120

 tgtcaggtga atcaagcaag catattgttg tctagcatcc ttaggattac attaaaatca    180

 gcagattggc aagttatgat taggttagac ttgacatatg cagaaattat gcttctgtat    240

 ttttatatta aaagcaccat ggtttttttg aatgaaataa tgaaagcaag cttttaagac    300

 ataacttttt taaaaaatta aaaatctgtc tttggttagt ttataaacat gaagcatatc    360

 ctcctcttct tccccccaaa atttttgttt aagtcttaag aaagtcttta gcaaggtatg    420

 accagtactt aagtgcactg gttgcataag ccttctgtct ccaggtaaaa gtttgctaat    480

 tgacagggta ttattgttca gaatctttag agggagagaa  atg aaa ggc aac agt     535
                                              Met Lys Gly Asn Ser
                                                1               5

 gaa cag tgt ttg ctg ctc tgt aca ctc gga cga act gtg gtt gct act      583
 Glu Gln Cys Leu Leu Leu Cys Thr Leu Gly Arg Thr Val Val Ala Thr
                  10                  15                  20

 ctg tac act cgg acg aac tgt ggt tgc tgt ctt caa gga gat gaa cag      631
 Leu Tyr Thr Arg Thr Asn Cys Gly Cys Cys Leu Gln Gly Asp Glu Gln
              25                  30                  35

 ctt atc tgc att gaa cgt ctg ctg agg cag gta gcc tgc ctc tta aat      679
 Leu Ile Cys Ile Glu Arg Leu Leu Arg Gln Val Ala Cys Leu Leu Asn
          40                  45                  50

 gag ctc tgc aca gat ctt agg gaa gac ctt aac agt tac agg tca tgt      727
 Glu Leu Cys Thr Asp Leu Arg Glu Asp Leu Asn Ser Tyr Arg Ser Cys
      55                  60                  65

 ggt gac ctg atc att cac agt cat att gta taa attccaaa caggcctgga      778
 Gly Asp Leu Ile Ile His Ser His Ile Val 
  70                  75

 gccttggcaa ttgtctgtgg tatgtgataa cacttctact atgcttacct               828




      <210> 81
      <211> 811
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (42)..(710)

      <400> 81
 cggccgcgtc gacgaggcag cactctcggg acgtctccac c    atg gcc tgg gct      53
                                                  Met Ala Trp Ala
                                                    1

 ctt ctc ctc ctc agc ctc ctc act cag ggc aca ggg tcc tgg gcc cag      101
 Leu Leu Leu Leu Ser Leu Leu Thr Gln Gly Thr Gly Ser Trp Ala Gln
   5                  10                  15                  20

 tct gcc ctg act cag cct ccc tcc gcg tcc ggg tct cct gga cag tca      149
 Ser Ala Leu Thr Gln Pro Pro Ser Ala Ser Gly Ser Pro Gly Gln Ser
                  25                  30                  35

 gtc acc atc tcc tgc act gga acc agc agt gac gtt ggt ggt tat aac      197
 Val Thr Ile Ser Cys Thr Gly Thr Ser Ser Asp Val Gly Gly Tyr Asn
              40                  45                  50

 tat gtc tcc tgg tac caa cag cac cca ggc aaa gcc ccc aaa ctc atg      245
 Tyr Val Ser Trp Tyr Gln Gln His Pro Gly Lys Ala Pro Lys Leu Met
          55                  60                  65

 att tat gag gtc agt aag cgg ccc tca ggg gtc cct gat cgc ttc tct      293
 Ile Tyr Glu Val Ser Lys Arg Pro Ser Gly Val Pro Asp Arg Phe Ser
      70                  75                  80

 ggc tcc aag tct ggc aac acg gcc tcc ctg acc gtc tct ggg ctc cag      341
 Gly Ser Lys Ser Gly Asn Thr Ala Ser Leu Thr Val Ser Gly Leu Gln
  85                  90                  95                 100

 gct gag gat gag gct gat tat tac tgc agc tca tat gca ggc agc aac      389
 Ala Glu Asp Glu Ala Asp Tyr Tyr Cys Ser Ser Tyr Ala Gly Ser Asn
                 105                 110                 115

 aat ttc gtc ttc gga act ggg acc aag gtc acc gtc cta ggt cag ccc      437
 Asn Phe Val Phe Gly Thr Gly Thr Lys Val Thr Val Leu Gly Gln Pro
             120                 125                 130

 aag gcc aac ccc act gtc act ctg ttc ccg ccc tcc tct gag gag ctc      485
 Lys Ala Asn Pro Thr Val Thr Leu Phe Pro Pro Ser Ser Glu Glu Leu
         135                 140                 145

 caa gcc aac aag gcc aca cta gtg tgt ctg atc agt gac ttc tac ccg      533
 Gln Ala Asn Lys Ala Thr Leu Val Cys Leu Ile Ser Asp Phe Tyr Pro
     150                 155                 160

 gga gct gtg aca gtg gcc tgg cac agg cag atg gca gcc ccg tca agg      581
 Gly Ala Val Thr Val Ala Trp His Arg Gln Met Ala Ala Pro Ser Arg
 165                 170                 175                 180

 cgg gga gtg gag acc acc aaa gcc tcc aaa cag agc aaa cga gca agt      629
 Arg Gly Val Glu Thr Thr Lys Ala Ser Lys Gln Ser Lys Arg Ala Ser
                 185                 190                 195

 acg cgg cca gca gac tac ctg agc ctg acg ccc gag cag ggg aag tcc      677
 Thr Arg Pro Ala Asp Tyr Leu Ser Leu Thr Pro Glu Gln Gly Lys Ser
             200                 205                 210

 cac aga agc tac agc ctg cag gtc acc gca tga acgggagc accgggagaa      728
 His Arg Ser Tyr Ser Leu Gln Val Thr Ala 
         215                 220

 gacaggggcc ctacagaatg ttcaacggtt ccaaatctaa cccagccagg aacgggagct    788

 gaagaacccg ggagggcccc tcc                                            811




      <210> 82
      <211> 841
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (106)..(486)

      <400> 82
 atgaaggatc tttgtgggaa aaaagcagaa gagatgatgc aggtggcctc ctgggaaagt     60

 ggaggcaacc tgaaattgga taatggggtc caccctacac tgggc    atg aga aaa     114
                                                      Met Arg Lys
                                                        1

 atg ggc caa ttc aca gct gca atg gtt ggg aga att tcc tgt ctg gga      162
 Met Gly Gln Phe Thr Ala Ala Met Val Gly Arg Ile Ser Cys Leu Gly
       5                  10                  15

 gtc tgg aaa ctg cca aga gtg gaa agc tgc agc cag cca gcg agg cct      210
 Val Trp Lys Leu Pro Arg Val Glu Ser Cys Ser Gln Pro Ala Arg Pro
  20                  25                  30                  35

 ttg ttg tca ctg gcc caa aca aca aca aaa aca acc gca aca aca aca      258
 Leu Leu Ser Leu Ala Gln Thr Thr Thr Lys Thr Thr Ala Thr Thr Thr
                  40                  45                  50

 aca aca aca aaa cat gcc acg tgt gca ctg gca tat aca aac acg ccc      306
 Thr Thr Thr Lys His Ala Thr Cys Ala Leu Ala Tyr Thr Asn Thr Pro
              55                  60                  65

 aca gaa cca aac caa gcg gac aag gct tca agg aga gct tct ggg cgg      354
 Thr Glu Pro Asn Gln Ala Asp Lys Ala Ser Arg Arg Ala Ser Gly Arg
          70                  75                  80

 ctc att ccc gcg gcg agg cat atc cct tgg cat ggt gcc act gca gcc      402
 Leu Ile Pro Ala Ala Arg His Ile Pro Trp His Gly Ala Thr Ala Ala
      85                  90                  95

 cag ctc cca gcc ccc ccg cca tct gtc atc agc gct ctg cct act gta      450
 Gln Leu Pro Ala Pro Pro Pro Ser Val Ile Ser Ala Leu Pro Thr Val
 100                 105                 110                 115

 agt gtg ccg aca cag tac acg gag gct aac aag tag caaa tggaggggaa      500
 Ser Val Pro Thr Gln Tyr Thr Glu Ala Asn Lys 
                 120                 125

 gaaaaaacaa agccactgca gtcagtggga gaggtggcta gggctttgac ataaactgac    560

 aaaaagctgg gaaatttaaa ctgaaagttt gccctcaaga ctttcagctg tgagggttgg    620

 actggggagg agggaagggt acggtgaggg aggttggcag ggagcagtct gcaaaaaagc    680

 tggtgagata gagttaagta ggccggcttt ttccagactc tatgaataat atgagacatt    740

 acttaaaatc cattctgact gttcatagat tgcccaagaa ggctttccct tacaacaaaa    800

 aaaaaaaaag gaactaaaaa aaaaaaaaaa aaaaaaaata t                        841




      <210> 83
      <211> 3298
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (260)..(1276)

      <400> 83
 gtgcgtgcct tggaggactg ctctgaactc tgtgcagatt ggtgctgatg attcttacca     60

 gttgtgtgca agaaaagaaa tcagagacgc tgcctgcctg ctcccatctc tcgcgcgctc    120

 tctctctctt ctgctctctc cctccctttg caaacattgg atttaaacct gctcagaatt    180

 cagcacagag gaaggcagca gcggtagcag cagcagaagc agtagcaagc ccggcagctg    240

 agagcaccgc agcgtcgag atg tac cat cct gcc tac tgg gtc gtc ttc tcg     292
                      Met Tyr His Pro Ala Tyr Trp Val Val Phe Ser
                        1               5                  10

 gcg aca act gcc ctg ctc ttc atc cca gga gtg ccc gtg cgc agc gga      340
 Ala Thr Thr Ala Leu Leu Phe Ile Pro Gly Val Pro Val Arg Ser Gly
              15                  20                  25

 gat gcc acc ttc ccc aaa gct atg gac aac gtg acg gtc cgg cag ggg      388
 Asp Ala Thr Phe Pro Lys Ala Met Asp Asn Val Thr Val Arg Gln Gly
          30                  35                  40

 gag agc gcc acc ctc agg tgt acc ata gat gac cgg gta acc cgg gtg      436
 Glu Ser Ala Thr Leu Arg Cys Thr Ile Asp Asp Arg Val Thr Arg Val
      45                  50                  55

 gcc tgg cta aac cgc agc acc atc ctc tac gct ggg aat gac aag tgg      484
 Ala Trp Leu Asn Arg Ser Thr Ile Leu Tyr Ala Gly Asn Asp Lys Trp
  60                  65                  70                  75

 tcc ata gac cct cgt gtg atc atc ctg gtc aat aca cca acc cag tac      532
 Ser Ile Asp Pro Arg Val Ile Ile Leu Val Asn Thr Pro Thr Gln Tyr
                  80                  85                  90

 agc atc atg atc caa aat gtg gat gtg tat gac gaa ggt ccg tac acc      580
 Ser Ile Met Ile Gln Asn Val Asp Val Tyr Asp Glu Gly Pro Tyr Thr
              95                 100                 105

 tgc tct gtg cag aca gac aat cat ccc aaa acg tcc cgg gtt cac cta      628
 Cys Ser Val Gln Thr Asp Asn His Pro Lys Thr Ser Arg Val His Leu
         110                 115                 120

 ata gtg caa gtt cct cct cag atc atg aat atc tcc tca gac atc act      676
 Ile Val Gln Val Pro Pro Gln Ile Met Asn Ile Ser Ser Asp Ile Thr
     125                 130                 135

 gtg aat gag gga agc agt gtg acc ctg ctg tgt ctt gct att ggc aga      724
 Val Asn Glu Gly Ser Ser Val Thr Leu Leu Cys Leu Ala Ile Gly Arg
 140                 145                 150                 155

 cca gag cca act gtg aca tgg aga cac ctg tca gtc aag gaa ggc cag      772
 Pro Glu Pro Thr Val Thr Trp Arg His Leu Ser Val Lys Glu Gly Gln
                 160                 165                 170

 ggc ttt gta agt gag gat gag tac ctg gag atc tct gac atc aag cga      820
 Gly Phe Val Ser Glu Asp Glu Tyr Leu Glu Ile Ser Asp Ile Lys Arg
             175                 180                 185

 gac cag tcc ggg gag tac gaa tgc agc gcg ttg aac gat gtc gct gcg      868
 Asp Gln Ser Gly Glu Tyr Glu Cys Ser Ala Leu Asn Asp Val Ala Ala
         190                 195                 200

 ccc gat gtg cgg aaa gta aaa atc act gta aac tat cct ccc tat atc      916
 Pro Asp Val Arg Lys Val Lys Ile Thr Val Asn Tyr Pro Pro Tyr Ile
     205                 210                 215

 tca aaa gcc aag aac act ggt gtt tca gtc ggt cag aag ggc atc ctg      964
 Ser Lys Ala Lys Asn Thr Gly Val Ser Val Gly Gln Lys Gly Ile Leu
 220                 225                 230                 235

 agc tgt gaa gcc tct gca gtc ccc atg gct gaa ttc cag tgg ttc aag     1012
 Ser Cys Glu Ala Ser Ala Val Pro Met Ala Glu Phe Gln Trp Phe Lys
                 240                 245                 250

 gaa gaa acc agg tta gcc act ggt ctg gat gga atg agg att gaa aac     1060
 Glu Glu Thr Arg Leu Ala Thr Gly Leu Asp Gly Met Arg Ile Glu Asn
             255                 260                 265

 aaa ggc cgc atg tcc act ctg act ttc ttc aat gtt tct gaa aag gat     1108
 Lys Gly Arg Met Ser Thr Leu Thr Phe Phe Asn Val Ser Glu Lys Asp
         270                 275                 280

 tat ggg aac tat act tgt gtg gcc acg aac aag ctt ggg aac acc aat     1156
 Tyr Gly Asn Tyr Thr Cys Val Ala Thr Asn Lys Leu Gly Asn Thr Asn
     285                 290                 295

 gcc agc atc aca ttg tat ggg cct gga gca gtc att gat ggt gta aac     1204
 Ala Ser Ile Thr Leu Tyr Gly Pro Gly Ala Val Ile Asp Gly Val Asn
 300                 305                 310                 315

 tcg gcc tcc aga gca ctg gct tgt ctc tgg cta tca ggg acc ctc tta     1252
 Ser Ala Ser Arg Ala Leu Ala Cys Leu Trp Leu Ser Gly Thr Leu Leu
                 320                 325                 330

 gcc cac ttc ttc atc aag ttt tga taagaaatcc taggtcctct gagcaacgcc    1306
 Ala His Phe Phe Ile Lys Phe 
             335

 tgcttctcat atcacagact ttaatctaca ctgcggagag caaaccagct tgggcttctt   1366

 tttgtttttt tctgttattc tagatttgtt ttctttttgt ttttgtttat ttgtttgttt   1426

 gcttttattt ccagcttgaa tgagtggggt tgggggcggg gtgggcaggg ttctaccacg   1486

 tgtaggataa tcattcattg gtgtgtccaa aaatggggtc tgctcctgct accttgaccc   1546

 ttccctttcc tctgcttctc tcctcatcat cattcccaac aacatcctct gccacacaca   1606

 acaaaacgta agtttcattt gggcaaaaat tgagcctcac aataaacacc ctgaagacac   1666

 aacttgactt ataacatagt gcacagcaag agctacatcc aagtgtccta ttatctgtga   1726

 ttattttctt aatgacaatg tacatatgcc cccatccatg ttaattatta tctaattcca   1786

 ttagggttca cgtcttttct ttctgggaca ctatcctact atatccatat ctatagattt   1846

 caatatagat gattgtgcca tcttctgtag cccctccgct ctactcattc cttccaccat   1906

 ctgcagagat ttgaagtttg gggctatgca tgaaacccaa cactaaattt tgcaagtcaa   1966

 gtgaccaaaa aagggggagg cattttgaag atagaacctc tattttaaaa agagaagttc   2026

 aactcataaa cgtgattgat aggtggctga tttatttagg ttttgtcaag ctatctatca   2086

 aagtaatggt acagttaccc atctactcaa atatctgatt tatctcacca tccaattatc   2146

 tacccacctg tcttcctctc tagcaatcta tttactgttt atcaatctat caatgtaatt   2206

 gtctaacact cctttctatt ctctccctac tactcactat caattcatcc ccatatgaat   2266

 ctctaaccat attgtatctc tcccactgta ttcatttata caccatcagc agacattggc   2326

 atcttcaaaa ttatctttca acttctgtga aagccaacga tctcacaggt taacaaaata   2386

 caaaagcaat accctgtgtt gtggactctt taaaatctgg tatcctatcc acccaaggga   2446

 gacactaaca gataggccaa agtagcaagc taatgatcag tcactcacta ttcccggaag   2506

 agcctgtgtt ttctaaaaca ctttcttggg aagcagatca gcctagaaaa gttttgatta   2566

 gcactgtggt tttccttttg cacttgaagg acaaaggtgc cagcctttat gcttctctca   2626

 acccttcaag aaagtacatg tcaggaacct atggctggct ttccttagca gcaagaactt   2686

 gagagaaaaa cacatctgtc tctgcaatgc aaagtgaaga gtccacccgc ctgagtggga   2746

 tgacttcagc tagagtctcc tttctgctcc agttctggtt taatctgttt gaaaactatc   2806

 cagtaaaaag ctgatggagg ccaattacat ggcgggtgta ttgacaactc tggtatttgt   2866

 ttcaggaagc tcttctaagc tgagggcact tgagcaactg acttaatttt caagcacttg   2926

 attaacacaa cactgcaaac agaagggaga aagtgtcagt gacacagttt cctctgatgc   2986

 agctgcttct ccaatggctt tggggaagaa cttcaccagc tcttcaggtt caaagcagac   3046

 ccagcataca aacaagagct gagccacctt tgctgtcttg tctcctggga cgagaaggac   3106

 tcatccagca aagttgcctg ggattcaaaa taaaggcatt gcagaccgca caggtgtgct   3166

 gcagggactg atccacagag aggatgagaa tgcagcatca atcgcagacc tgccctgcct   3226

 cagttggaaa accttttcag gccctcagtc taaaaaataa aaaatatgag caccaaaaaa   3286

 aaaaaaaaaa aa                                                       3298




      <210> 84
      <211> 1521
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (1)..(1521)

      <400> 84
  atg cac ggc tcc tgc agt ttc ctg atg ctt ctg ctg ccg cta ctg cta      48
  Met His Gly Ser Cys Ser Phe Leu Met Leu Leu Leu Pro Leu Leu Leu
    1               5                  10                  15

 ctg ctg gtg gcc acc aca ggc ccc gtt gga gcc ctc aca gat gag gag       96
 Leu Leu Val Ala Thr Thr Gly Pro Val Gly Ala Leu Thr Asp Glu Glu
              20                  25                  30

 aaa cgt ttg atg gtg gag ctg cac aac ctc tac cgg gcc cag gta tcc      144
 Lys Arg Leu Met Val Glu Leu His Asn Leu Tyr Arg Ala Gln Val Ser
          35                  40                  45

 ccg acg gcc tca gac atg ctg cac atg aga tgg gac gag gag ctg gcc      192
 Pro Thr Ala Ser Asp Met Leu His Met Arg Trp Asp Glu Glu Leu Ala
      50                  55                  60

 gcc ttc gcc aag gcc tac gca cgg cag tgc gtg tgg ggc cac aac aag      240
 Ala Phe Ala Lys Ala Tyr Ala Arg Gln Cys Val Trp Gly His Asn Lys
  65                  70                  75                  80

 gag cgc ggg cgc cgc ggc gag aat ctg ttc gcc atc aca gac gag ggc      288
 Glu Arg Gly Arg Arg Gly Glu Asn Leu Phe Ala Ile Thr Asp Glu Gly
                  85                  90                  95

 atg gac gtg ccg ctg gcc atg gag gag tgg cac cac gag cgt gag cac      336
 Met Asp Val Pro Leu Ala Met Glu Glu Trp His His Glu Arg Glu His
             100                 105                 110

 tac aac ctc agc gcc gcc acc tgc agc cca ggc cag atg tgc ggc cac      384
 Tyr Asn Leu Ser Ala Ala Thr Cys Ser Pro Gly Gln Met Cys Gly His
         115                 120                 125

 tac acg cag gtg gta tgg gcc aag aca gag agg atc ggc tgt ggt tcc      432
 Tyr Thr Gln Val Val Trp Ala Lys Thr Glu Arg Ile Gly Cys Gly Ser
     130                 135                 140

 cac ttc tgt gag aag ctc cag ggt gtt gag gag acc aac atc gaa tta      480
 His Phe Cys Glu Lys Leu Gln Gly Val Glu Glu Thr Asn Ile Glu Leu
 145                 150                 155                 160

 ctg gtg tgc aac tat gag cct ccg ggg aac gtg aag ggg aaa cgg ccc      528
 Leu Val Cys Asn Tyr Glu Pro Pro Gly Asn Val Lys Gly Lys Arg Pro
                 165                 170                 175

 tac cag gag ggg act ccg tgc tcc caa tgt ccc tct ggc tac cac tgc      576
 Tyr Gln Glu Gly Thr Pro Cys Ser Gln Cys Pro Ser Gly Tyr His Cys
             180                 185                 190

 aag aac tcc ctc tgt ggt gag tcc acg ggt gga tgg ccc ccc acg cgc      624
 Lys Asn Ser Leu Cys Gly Glu Ser Thr Gly Gly Trp Pro Pro Thr Arg
         195                 200                 205

 agc cac ttt ggc gcc ctg tcg ttc caa gtg gcc gga ttt caa ccc ttc      672
 Ser His Phe Gly Ala Leu Ser Phe Gln Val Ala Gly Phe Gln Pro Phe
     210                 215                 220

 aaa ggg agg atg tta gaa agt ctg gcg gct tcg ggg ggg ccc gcg cga      720
 Lys Gly Arg Met Leu Glu Ser Leu Ala Ala Ser Gly Gly Pro Ala Arg
 225                 230                 235                 240

 gaa ccc atc gga agc ccg gaa gat gct cag gat ttg cct tac ctg gta      768
 Glu Pro Ile Gly Ser Pro Glu Asp Ala Gln Asp Leu Pro Tyr Leu Val
                 245                 250                 255

 act gag gcc cca tcc ttc cgg gcg act gaa gca tca gac tct agg aaa      816
 Thr Glu Ala Pro Ser Phe Arg Ala Thr Glu Ala Ser Asp Ser Arg Lys
             260                 265                 270

 atg ggt act cct tct tcc cta gca acg ggg att ccg gct ttc ttg gta      864
 Met Gly Thr Pro Ser Ser Leu Ala Thr Gly Ile Pro Ala Phe Leu Val
         275                 280                 285

 aca gag gtc tca ggc tcc ctg gca acc aag gct ctg cct gct gtg gaa      912
 Thr Glu Val Ser Gly Ser Leu Ala Thr Lys Ala Leu Pro Ala Val Glu
     290                 295                 300

 acc cag gcc cca act tcc tta gca acg aaa gac ccg ccc tcc atg gca      960
 Thr Gln Ala Pro Thr Ser Leu Ala Thr Lys Asp Pro Pro Ser Met Ala
 305                 310                 315                 320

 aca gag gct cca cct tgc gta aca act gag gtc cct tcc att ttg gca     1008
 Thr Glu Ala Pro Pro Cys Val Thr Thr Glu Val Pro Ser Ile Leu Ala
                 325                 330                 335

 gct cac agc ctg ccc tcc ttg gat gag gag cca gtt acc ttc ccc aaa     1056
 Ala His Ser Leu Pro Ser Leu Asp Glu Glu Pro Val Thr Phe Pro Lys
             340                 345                 350

 tcg acc cat gtt cct atc cca aaa tca gca gac aaa gtg aca gac aaa     1104
 Ser Thr His Val Pro Ile Pro Lys Ser Ala Asp Lys Val Thr Asp Lys
         355                 360                 365

 aca aaa gtg ccc tct agg agc cca gag aac tct ctg gac ccc aag atg     1152
 Thr Lys Val Pro Ser Arg Ser Pro Glu Asn Ser Leu Asp Pro Lys Met
     370                 375                 380

 tcc ctg aca ggg gca agg gaa ctc cta ccc cat gcc cag gag gag gct     1200
 Ser Leu Thr Gly Ala Arg Glu Leu Leu Pro His Ala Gln Glu Glu Ala
 385                 390                 395                 400

 gag gct gag gct gag ttg cct cct tcc agt gag gtc ttg gcc tca gtt     1248
 Glu Ala Glu Ala Glu Leu Pro Pro Ser Ser Glu Val Leu Ala Ser Val
                 405                 410                 415

 ttt cca gcc cag gac aag cca ggt gag ctg cag gcc aca ctg gac cac     1296
 Phe Pro Ala Gln Asp Lys Pro Gly Glu Leu Gln Ala Thr Leu Asp His
             420                 425                 430

 acg ggg cac acc tcc tcc aag tcc ctg ccc aat ttc ccc aat acc tct     1344
 Thr Gly His Thr Ser Ser Lys Ser Leu Pro Asn Phe Pro Asn Thr Ser
         435                 440                 445

 gcc acc gct aat gcc acg ggt ggg cgt gcc ctg gct ctg cag tcg tcc     1392
 Ala Thr Ala Asn Ala Thr Gly Gly Arg Ala Leu Ala Leu Gln Ser Ser
     450                 455                 460

 ttg cca ggt gca gag ggc cct gac aag cct agc gtc gtg tca ggg ctg     1440
 Leu Pro Gly Ala Glu Gly Pro Asp Lys Pro Ser Val Val Ser Gly Leu
 465                 470                 475                 480

 aac tcg ggc cct ggt cat gtg tgg ggc cct ctc ctg gga cta ctg ctc     1488
 Asn Ser Gly Pro Gly His Val Trp Gly Pro Leu Leu Gly Leu Leu Leu
                 485                 490                 495

 ctg cct cct ctg gtg ttg gct gga atc ttc tga                         1521
 Leu Pro Pro Leu Val Leu Ala Gly Ile Phe 
             500                 505





      <210> 85
      <211> 1644
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (1)..(1644)

      <400> 85
  atg tct cct agt act cag tgg cat cca ctg gcc aca ttc ttt ctc tct      48
  Met Ser Pro Ser Thr Gln Trp His Pro Leu Ala Thr Phe Phe Leu Ser
    1               5                  10                  15

 gtt ccc cat ctc atg cca gtg cat ctc cat cct tct gca gct gct gca       96
 Val Pro His Leu Met Pro Val His Leu His Pro Ser Ala Ala Ala Ala
              20                  25                  30

 gtc aga tcc atc atg tgg cca ctg aca gcc ctt ctg ctc ctg gtt cca      144
 Val Arg Ser Ile Met Trp Pro Leu Thr Ala Leu Leu Leu Leu Val Pro
          35                  40                  45

 agc agt ggg caa gct gct act ctg gag aag ccc ata ttg tct cta cat      192
 Ser Ser Gly Gln Ala Ala Thr Leu Glu Lys Pro Ile Leu Ser Leu His
      50                  55                  60

 cca cct tgg acc acc atc ttc aaa ggg gag cgg gta act ttg aag tgt      240
 Pro Pro Trp Thr Thr Ile Phe Lys Gly Glu Arg Val Thr Leu Lys Cys
  65                  70                  75                  80

 gat gga tac cac cca ctg ctc ctg gag ctc cag ccc atc agc act ctc      288
 Asp Gly Tyr His Pro Leu Leu Leu Glu Leu Gln Pro Ile Ser Thr Leu
                  85                  90                  95

 tgg tat ttg ggc cac cta ctt ctg ccc tct cac aag aag agc att gag      336
 Trp Tyr Leu Gly His Leu Leu Leu Pro Ser His Lys Lys Ser Ile Glu
             100                 105                 110

 gtg cag aca cca ggg gtg tat cga tgc cag aca cgg gga gca ccc gtc      384
 Val Gln Thr Pro Gly Val Tyr Arg Cys Gln Thr Arg Gly Ala Pro Val
         115                 120                 125

 agt gac ccc atc cac ctc tct gta tcc aat gat tgg ctg att ctg caa      432
 Ser Asp Pro Ile His Leu Ser Val Ser Asn Asp Trp Leu Ile Leu Gln
     130                 135                 140

 gtg ccc tat gcg cca gtg ttc gag ggt gag ccg cta gtc ctg cgc tgc      480
 Val Pro Tyr Ala Pro Val Phe Glu Gly Glu Pro Leu Val Leu Arg Cys
 145                 150                 155                 160

 cgc ggc tgg tac gac aag gtg gtc tac aag ctt cac tac tac cac gac      528
 Arg Gly Trp Tyr Asp Lys Val Val Tyr Lys Leu His Tyr Tyr His Asp
                 165                 170                 175

 ggc cag gcc gtg cgc tac ttc cac tcc agc gcc aac tac act gtg tta      576
 Gly Gln Ala Val Arg Tyr Phe His Ser Ser Ala Asn Tyr Thr Val Leu
             180                 185                 190

 cag gcg cgt gcc agc gac agc ggg cgc tac cag tgc tcg ggc acc atg      624
 Gln Ala Arg Ala Ser Asp Ser Gly Arg Tyr Gln Cys Ser Gly Thr Met
         195                 200                 205

 cgc atc ccg gtg gag agc gcg ccc atg ttc tcc gct aag gtg gct gtg      672
 Arg Ile Pro Val Glu Ser Ala Pro Met Phe Ser Ala Lys Val Ala Val
     210                 215                 220

 aca gtg caa gct ttc ccc gtc cct cgt gga ctc ggt ccc cct gcc cca      720
 Thr Val Gln Ala Phe Pro Val Pro Arg Gly Leu Gly Pro Pro Ala Pro
 225                 230                 235                 240

 cat ttc aga agg ctc ccc ttc ccc ctc cac gtg gac aca cgg cct cct      768
 His Phe Arg Arg Leu Pro Phe Pro Leu His Val Asp Thr Arg Pro Pro
                 245                 250                 255

 ccc ctc ccc cct tgg tct gtg ggt ctg caa gga gcc ctc gcg gga agc      816
 Pro Leu Pro Pro Trp Ser Val Gly Leu Gln Gly Ala Leu Ala Gly Ser
             260                 265                 270

 agg aag gag cgg ggt cgc gga gcg gtg gac aag ccg gcg ccg ttg ctc      864
 Arg Lys Glu Arg Gly Arg Gly Ala Val Asp Lys Pro Ala Pro Leu Leu
         275                 280                 285

 ccc gcc ctc tcc gta gag ctg ttc cgg gcg ccg gtg ctg agg gtg atg      912
 Pro Ala Leu Ser Val Glu Leu Phe Arg Ala Pro Val Leu Arg Val Met
     290                 295                 300

 ggt ccg cgg gag gcc cgc ggc gcg gcg ctg ggt ggg gtg gtg ctg cgc      960
 Gly Pro Arg Glu Ala Arg Gly Ala Ala Leu Gly Gly Val Val Leu Arg
 305                 310                 315                 320

 tgc gac acg cgc ctg cac ccg cag aag cgc gac acg ccg ctg cag ttc     1008
 Cys Asp Thr Arg Leu His Pro Gln Lys Arg Asp Thr Pro Leu Gln Phe
                 325                 330                 335

 gcg ttt tac aag tac agc cgc gcg gtg cgc cgc ttc gac tgg ggc gcc     1056
 Ala Phe Tyr Lys Tyr Ser Arg Ala Val Arg Arg Phe Asp Trp Gly Ala
             340                 345                 350

 gag tac aca gtc ccg gag ccc gag gtc gag gag ctc gaa tcg tac tgg     1104
 Glu Tyr Thr Val Pro Glu Pro Glu Val Glu Glu Leu Glu Ser Tyr Trp
         355                 360                 365

 tgc gag gcg gct acc gcc acc cgc agt gtc cgg aaa cgc agt ccg tgg     1152
 Cys Glu Ala Ala Thr Ala Thr Arg Ser Val Arg Lys Arg Ser Pro Trp
     370                 375                 380

 ctg cag ctc ccg ggg ccg gcc cag cgc cga gaa gaa cca tgc aag ccg     1200
 Leu Gln Leu Pro Gly Pro Ala Gln Arg Arg Glu Glu Pro Cys Lys Pro
 385                 390                 395                 400

 cgc gtg act ggg cgt aat gca ttc aca ggt tct ccc ctg gac ccg gcc     1248
 Arg Val Thr Gly Arg Asn Ala Phe Thr Gly Ser Pro Leu Asp Pro Ala
                 405                 410                 415

 tcc acc acc gcc cca gct cca tgg gcc gca gcc ttg gct cct ggt aat     1296
 Ser Thr Thr Ala Pro Ala Pro Trp Ala Ala Ala Leu Ala Pro Gly Asn
             420                 425                 430

 agg ccg ctt tcc ttc aga aag ccc ccg gtg tcc aga tcg gtc ccg ttg     1344
 Arg Pro Leu Ser Phe Arg Lys Pro Pro Val Ser Arg Ser Val Pro Leu
         435                 440                 445

 gtc acc tcc gtc cgg aac acc acc tcc acc ggg ctg cag ttc ccg gcg     1392
 Val Thr Ser Val Arg Asn Thr Thr Ser Thr Gly Leu Gln Phe Pro Ala
     450                 455                 460

 agc ggc gcc ccg act gcg ggg cca ccc gcc tgc gct ccg ccg acg ccc     1440
 Ser Gly Ala Pro Thr Ala Gly Pro Pro Ala Cys Ala Pro Pro Thr Pro
 465                 470                 475                 480

 ttg gaa caa tcg gct gga gcc ctg aaa ccc gac gtg gac ctt ctg ctc     1488
 Leu Glu Gln Ser Ala Gly Ala Leu Lys Pro Asp Val Asp Leu Leu Leu
                 485                 490                 495

 cga gaa atg cag ctg ctc aaa ggc ctt ctg agc cgg gtg gtc ctg gaa     1536
 Arg Glu Met Gln Leu Leu Lys Gly Leu Leu Ser Arg Val Val Leu Glu
             500                 505                 510

 tta aag gag cca cag gcc ctc cgg gag ctc agg gga acg ccc gag acc     1584
 Leu Lys Glu Pro Gln Ala Leu Arg Glu Leu Arg Gly Thr Pro Glu Thr
         515                 520                 525

 ccc acc tct cac ttt gct gtg agc ccg gga acc cca gag acc act cct     1632
 Pro Thr Ser His Phe Ala Val Ser Pro Gly Thr Pro Glu Thr Thr Pro
     530                 535                 540

 gtg gag agc tga                                                     1644
 Val Glu Ser 
 545





      <210> 86
      <211> 3625
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (963)..(1283)

      <400> 86
 ctgagagacc tggcctagtg acagagccag gattcaaagc catagatcat ggccccgggt     60

 tatgtaggtt attactgcat ctgttcaggg gagatggggt actgtgaggc tcgtcatggg    120

 aagcctggct tggtctcagg tcagggaagg cagatgtgag gaaatgacat ttatggtaaa    180

 gtctgagggt tgagtgggta ggttgggaag aacattccag aaagaagcac atgaactaca    240

 gcctggagtt ggaggaccta aaaggaagcc agcatggctg gagcacggag tggccattga    300

 gggaggcgag ctggagggct gcagcttctt gtattggcag tgctgacctc gcacagtcct    360

 tgggctccag tgacttcact cagtgtttat ctaacatgag tgagtgaatg gtgtttgctg    420

 tttttttggt aaaggtccca ggggttgtcg ggtacacagg tcctgtcttt ggccataagc    480

 aaactgaaat gaggcttggt ctccttccca ggatcccaca ccatgcctta catggtagac    540

 cccagtggga agtatgtgac tgcctgactc aggtgcctct cgtggtccaa gccatccctg    600

 ccctgtccct tccctggttg tcgccagacc tggagcccct gctccttcac tttgcagcct    660

 cctcttctgt caccaactgg gaacccacct cttcctgaaa gtcctccccc actgactcac    720

 cggcttgccc cgagcttgtc aagaatgtcc cagtaaccag gggacacaca ctgaagtgac    780

 tgaggggtta ccttggagtt gatgccttgg ctcagatcca gctcccctgt tttcttcctc    840

 tgtaaccttg ggcaacccaa cccctctaag cctcggtgtt ctcatttgtg aagttgtggt    900

 aataatggta gcttcctggt agaattattg taaatattaa attaatcaaa acatgaaaag    960

 ga   atg gaa cag tgc ttg gca cct agg aag cct tca gga aat gct atc    1007
      Met Glu Gln Cys Leu Ala Pro Arg Lys Pro Ser Gly Asn Ala Ile
        1               5                  10                  15

 tct tcc ctg ttg ata atc ttg acc cgt aca ctg cct ttg gtt gcc att     1055
 Ser Ser Leu Leu Ile Ile Leu Thr Arg Thr Leu Pro Leu Val Ala Ile
                  20                  25                  30

 cat gaa cct gcc acc aat agt aac aaa gtg ctg gat gca cct ttt gtg     1103
 His Glu Pro Ala Thr Asn Ser Asn Lys Val Leu Asp Ala Pro Phe Val
              35                  40                  45

 ctt atc ttt gtg cta aat gtg ccc gag gga cac cta ggg aag agg atg     1151
 Leu Ile Phe Val Leu Asn Val Pro Glu Gly His Leu Gly Lys Arg Met
          50                  55                  60

 cag gtc ttt aag agc cat cag ctc cag att atg gcc acc cca tgt cca     1199
 Gln Val Phe Lys Ser His Gln Leu Gln Ile Met Ala Thr Pro Cys Pro
      65                  70                  75

 gca ctt aga atg gag gcc aaa acc att ccc tcg gaa att gtg ttt cct     1247
 Ala Leu Arg Met Glu Ala Lys Thr Ile Pro Ser Glu Ile Val Phe Pro
  80                  85                  90                  95

 tgc caa gat ggg gac tgc gtg gtt gcc ctt ctc tga gggc agcgctggat     1297
 Cys Gln Asp Gly Asp Cys Val Val Ala Leu Leu 
                 100                 105

 ttttggcgtc tttcctttcc tgtcctggta cttggcacct tgtagacagt tgcatgtccc   1357

 ctgcccaggg atgggatgag gagagggcag gaaggcattt cctgggtagt ggagtgctgt   1417

 gttcattgag tgtgggttct ccaagctgct ggcacagcgc agggagggcc agatgcctct   1477

 caggagcctt gggcctgagt cctggctccc tcactcctgg gttccaggtc actgcatctg   1537

 tctctccacc atgtgctcca cctcgtgctg gaccttaaga gataccaatt atgtggctgc   1597

 cactgtgtcc tagaggctgg aatgggaaca catagggcga gattgattgt taattgctag   1657

 catgaaccgc gtgggcttct cagggtctag agtggagaga aatcggtaag aattggtggc   1717

 acgcctgtca gaactcccca gaccaagcta agcaaaaatt aaccaatcag tagagcagcc   1777

 ttcggagtaa gggctaaaat gatgtcctca gggcctggtt ttgctttcct tccatgtcag   1837

 tttgcttctt tgggtctggc tgcattccca gacaggccat gctctcgtgg tagcaaggtg   1897

 acatgacaca gggtcaggtc cagcaggaaa gaatgctgtc ctgtgtcccc acttcctcca   1957

 gaagccacac tcacccatcc cacctggctt ggtcctcatg tctatcccag aatccattaa   2017

 tggggccagg ggactatgac acaccacttg gcttagactg aggagctctg tgggcagccc   2077

 cacctgaagc tctgggacta agcctgcgag agagatggat tccccaaggg aaatggggcc   2137

 attgcttgag taaaaaggaa atagttgctg aagaggaaaa ccacgtgctt actccacata   2197

 gggcagactc ctggaagagg ggggcagggt agggaggtgg atatgcaggt tgccctggca   2257

 gggtctggaa atgggggctg caggcttgga gggaggcctc agtgtggctt ggaacgtggt   2317

 gtatggtggt ctgccgcgaa ggccggcctg cacaggggtg ggaggggggt gcttctgcat   2377

 gggaagcaca gacagcgctg cctctccctt gcactcagct cttggggcat gagaggctga   2437

 ctttccgtga gcctgtgggc caggcctctt tgaatggggc tgagggagct ttgccctggt   2497

 tcctttgtgt ccccacggtg ccacgggagg ctccctggca gggtgtgggg caaggcagtg   2557

 agtgaagagt tgggatgagt gagttagggc ccacggatta ctcaagacag gacttcaagt   2617

 tgattcaggc gtgttaggga gctgtgattg gattttgagc agggcaggga tgggacagaa   2677

 gagtttgggg aaggttcctc aggcatccgt cacggaaggg acaagaaggg agagagagtg   2737

 gatgccaggg acacccagaa gctgttattg tagtcaggat acgacagggg tgaggctaca   2797

 gacaggggac ttgcaagcag ggagggcagg gtgagacatt cagaggaaac gacgacagga   2857

 aatggtgaca gatagggaac gaggatgaag ggaagggaga gccagtgacg actggcagtg   2917

 gagtggggag caccgccacc tctcctcctc cacttgcccc tcctgtggca ctggacaagc   2977

 tagtgggctt ttcgttgtcc atgggctttt tcggtgggga tgtgaccagc tttgaacccg   3037

 tccccttaaa catgctcctc ctgcacggaa gagacagggg caggggagag actctctccc   3097

 caccacccag ctcaggcccc agcacagccc ggcctctggc ctcactggcg tctgtgccca   3157

 gtgacgcagg caggtgagct cctggcaaat tagcattgca ggctgtgctc tctcctcctg   3217

 ctctgctgca gctgggagtg tgcagagact ggaggggatg acagtcaccc tctgttttct   3277

 gtggtggctc tgttttctgt ggtgctggat gcacctctgt tttctgtggt ggctccaaga   3337

 gagtgcacgg tccctgctga ttgaaagaag gatgaagggc agaagagggg cggggagctg   3397

 tgtgccctaa gatctcattg cctttttatg ccgattaaca tgcttttagc ccctactgag   3457

 cttatagtta acagaagttt ccaggtcttt cttcacctga actgcgtcta aagcaagttc   3517

 cctccacctt ctgtattcat acgcttgatt tttaaaacct aaatgttggg cttcacattt   3577

 gttccttgta aatttcatct tggtgattgc agtctaccct ctggccac                3625




      <210> 87
      <211> 657
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (211)..(441)

      <400> 87
 cagctgcgtt tccgcggtcg cgggtgagtg tgcccgggct agcggcctgg gttgggcttt     60

 gtagctgctc cgcaggccca gcccgggccg cgctcgcaga gtcctaggcg gtgcgcggcc    120

 tcctgcctcc tccctcctcg gcggtcgcgg cccgccggcc tccgcggtgc ctgccttcgc    180

 tctcaggttg aggagctcaa gcttgggaaa     atg gtg tgc att cct tgt atc     231
                                      Met Val Cys Ile Pro Cys Ile
                                        1               5

 gtc att cca gtt ctg ctc tgg atc tac aaa aaa ttc ctg gag cca tat      279
 Val Ile Pro Val Leu Leu Trp Ile Tyr Lys Lys Phe Leu Glu Pro Tyr
          10                  15                  20

 ata tac cct ctg gtt tcc ccc ttc gtt agt cgt ata tgg cct aag aaa      327
 Ile Tyr Pro Leu Val Ser Pro Phe Val Ser Arg Ile Trp Pro Lys Lys
      25                  30                  35

 gca ata caa gaa tcc aat gat aca aac aaa ggc aaa gta aac ttt aag      375
 Ala Ile Gln Glu Ser Asn Asp Thr Asn Lys Gly Lys Val Asn Phe Lys
  40                  45                  50                  55

 ggt gca gac atg aat gga tta cca aca aaa gga cca aca gaa atc tgt      423
 Gly Ala Asp Met Asn Gly Leu Pro Thr Lys Gly Pro Thr Glu Ile Cys
                  60                  65                  70

 gat aaa aag aaa gac taa agaaat tttcctaaag gaccccatca tttaaaaaat      477
 Asp Lys Lys Lys Asp 
              75

 ggacctgata atatgaagca tcttccttgt aattgtctct gaccttttta tctgagaccg    537

 gaattcagga taggagtcta gatatttacc tgatactaat caggaaatat atgatatccg    597

 tatttaaaat gtagttagtt atatttaatg acctcattcc taagttcctt tttcgttaat    657




      <210> 88
      <211> 1431
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (1)..(1431)

      <400> 88
  atg gcg gcc tgc agg tac tgc tgc tcg tgc ctc cgg ctc cgg ccc ctg      48
  Met Ala Ala Cys Arg Tyr Cys Cys Ser Cys Leu Arg Leu Arg Pro Leu
    1               5                  10                  15

 agc gat ggt cct ttc ctt ctg cca cgg cgg gat cgg gca ctc acc cag       96
 Ser Asp Gly Pro Phe Leu Leu Pro Arg Arg Asp Arg Ala Leu Thr Gln
              20                  25                  30

 ttg caa gtg cga gca cta tgg agt agc gca ggg tct cga gct gtg gcc      144
 Leu Gln Val Arg Ala Leu Trp Ser Ser Ala Gly Ser Arg Ala Val Ala
          35                  40                  45

 gtg gac tta ggc aac agg aac tta cca gcg ttg ttc ttt atg ttt aag      192
 Val Asp Leu Gly Asn Arg Asn Leu Pro Ala Leu Phe Phe Met Phe Lys
      50                  55                  60

 tca ggt gac act gca gta atg gtc aca gcg gtc agt aaa aca aaa cct      240
 Ser Gly Asp Thr Ala Val Met Val Thr Ala Val Ser Lys Thr Lys Pro
  65                  70                  75                  80

 tcc cct tcc cag ttt atg cct ttg gtg gtt gac tac aga caa aag gct      288
 Ser Pro Ser Gln Phe Met Pro Leu Val Val Asp Tyr Arg Gln Lys Ala
                  85                  90                  95

 gct gca gta gga atg act gat gga gaa tgt gtt gtt aac cca aca aga      336
 Ala Ala Val Gly Met Thr Asp Gly Glu Cys Val Val Asn Pro Thr Arg
             100                 105                 110

 aaa gaa atg tct tct agt act tta aat gta gtg gtt gct gga gca cct      384
 Lys Glu Met Ser Ser Ser Thr Leu Asn Val Val Val Ala Gly Ala Pro
         115                 120                 125

 aaa agt cag act gtc atg ttg gaa gcc tct gca gag aac att tta cag      432
 Lys Ser Gln Thr Val Met Leu Glu Ala Ser Ala Glu Asn Ile Leu Gln
     130                 135                 140

 cag gac ttt tgc cac gct atc aaa gtg gga gtg aaa tat acc cag caa      480
 Gln Asp Phe Cys His Ala Ile Lys Val Gly Val Lys Tyr Thr Gln Gln
 145                 150                 155                 160

 ata att cag ggc atc cag cag ctg gta aaa gaa att ggt gtt acc aag      528
 Ile Ile Gln Gly Ile Gln Gln Leu Val Lys Glu Ile Gly Val Thr Lys
                 165                 170                 175

 agg aca cct cag aag tta ttt acc cct tca caa gag att gtg aaa cat      576
 Arg Thr Pro Gln Lys Leu Phe Thr Pro Ser Gln Glu Ile Val Lys His
             180                 185                 190

 gct cat aaa ctc act atg gag aga ctc tat gca gtt ttt aca gat tat      624
 Ala His Lys Leu Thr Met Glu Arg Leu Tyr Ala Val Phe Thr Asp Tyr
         195                 200                 205

 gaa cat gat aaa att tcc aga gat gaa gct gtt aac aaa ata aga tta      672
 Glu His Asp Lys Ile Ser Arg Asp Glu Ala Val Asn Lys Ile Arg Leu
     210                 215                 220

 gat aca gag gaa caa cta aaa gaa ata ttt cca gag gtc gat cta tat      720
 Asp Thr Glu Glu Gln Leu Lys Glu Ile Phe Pro Glu Val Asp Leu Tyr
 225                 230                 235                 240

 gag ata ata gaa tcc ttc aat act gtt gca aag gaa gtt ttt aga agt      768
 Glu Ile Ile Glu Ser Phe Asn Thr Val Ala Lys Glu Val Phe Arg Ser
                 245                 250                 255

 att att ttg aat gaa tac aaa aga tgc gat ggt cgg gat ttg act tta      816
 Ile Ile Leu Asn Glu Tyr Lys Arg Cys Asp Gly Arg Asp Leu Thr Leu
             260                 265                 270

 ctt cgg aat ata agt tgt gag gta gat atg ttt aaa acc ctt cat gga      864
 Leu Arg Asn Ile Ser Cys Glu Val Asp Met Phe Lys Thr Leu His Gly
         275                 280                 285

 tca gaa tta ttt caa aga gga caa aca cag ctg ctt tgt gct gtt aca      912
 Ser Glu Leu Phe Gln Arg Gly Gln Thr Gln Leu Leu Cys Ala Val Thr
     290                 295                 300

 ttt gat tca tta gaa tcc agt att aag ttg gat cga gtt ata aca act      960
 Phe Asp Ser Leu Glu Ser Ser Ile Lys Leu Asp Arg Val Ile Thr Thr
 305                 310                 315                 320

 ata aat ggg ata aaa gat aaa aat ttc atg ctg cac tat gag ttt cct     1008
 Ile Asn Gly Ile Lys Asp Lys Asn Phe Met Leu His Tyr Glu Phe Pro
                 325                 330                 335

 cct tat gca act aat gaa att gtc aaa gtc acc ggt ata aat aga aga     1056
 Pro Tyr Ala Thr Asn Glu Ile Val Lys Val Thr Gly Ile Asn Arg Arg
             340                 345                 350

 gaa ctt ggg cct ggt gct ctt gct gag aaa gct ttg tat cct gtt att     1104
 Glu Leu Gly Pro Gly Ala Leu Ala Glu Lys Ala Leu Tyr Pro Val Ile
         355                 360                 365

 ccc aaa gat ttt cct ttt gcc ata aga gtt aca tct gaa gtc cta gag     1152
 Pro Lys Asp Phe Pro Phe Ala Ile Arg Val Thr Ser Glu Val Leu Glu
     370                 375                 380

 tca aat ggg tca tct tct atg gca tct gca tgt ggt gta gca atg gga     1200
 Ser Asn Gly Ser Ser Ser Met Ala Ser Ala Cys Gly Val Ala Met Gly
 385                 390                 395                 400

 ttg gcc acc aaa acc gat ctt gag aag ggt gaa ata gaa gat tat cat     1248
 Leu Ala Thr Lys Thr Asp Leu Glu Lys Gly Glu Ile Glu Asp Tyr His
                 405                 410                 415

 ttg cta aca gat att ctg gga att gaa gct tac aat ggt gac atg gac     1296
 Leu Leu Thr Asp Ile Leu Gly Ile Glu Ala Tyr Asn Gly Asp Met Asp
             420                 425                 430

 ttc aaa ata gct ggc act aat aaa gga ata act gca tta cag gca gat     1344
 Phe Lys Ile Ala Gly Thr Asn Lys Gly Ile Thr Ala Leu Gln Ala Asp
         435                 440                 445

 att aaa tta cct gga ata aca atg aaa att gta atg gag gct att caa     1392
 Ile Lys Leu Pro Gly Ile Thr Met Lys Ile Val Met Glu Ala Ile Gln
     450                 455                 460

 caa gct tca gtg gca aaa agg aga ttt tac aga tca tga                 1431
 Gln Ala Ser Val Ala Lys Arg Arg Phe Tyr Arg Ser 
 465                 470                 475





      <210> 89
      <211> 735
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (17)..(376)

      <400> 89
 cgcttcagtc gtcagc    atg gct cgc tcg gtg acc ctg gtc ttt ctg gtg      49
                      Met Ala Arg Ser Val Thr Leu Val Phe Leu Val
                        1               5                  10

 ctt gtc tca ctg acc ggc ctg tat gct atc cag aaa acc cct caa att       97
 Leu Val Ser Leu Thr Gly Leu Tyr Ala Ile Gln Lys Thr Pro Gln Ile
              15                  20                  25

 caa gta tac tca cgc cac cca ccg gag aat ggg aag ccg aac ata ctg      145
 Gln Val Tyr Ser Arg His Pro Pro Glu Asn Gly Lys Pro Asn Ile Leu
          30                  35                  40

 aac tgc tac gta aca cag ttc cac ccg cct cac att gaa atc caa atg      193
 Asn Cys Tyr Val Thr Gln Phe His Pro Pro His Ile Glu Ile Gln Met
      45                  50                  55

 ctg aag aac ggg aaa aaa att cct aaa gtt gag atg tca gat atg tcc      241
 Leu Lys Asn Gly Lys Lys Ile Pro Lys Val Glu Met Ser Asp Met Ser
  60                  65                  70                  75

 ttt gac aag gac tgg gcc ttt cta ttc ctg gct cac act gaa ttc acc      289
 Phe Asp Lys Asp Trp Ala Phe Leu Phe Leu Ala His Thr Glu Phe Thr
                  80                  85                  90

 ccc act gag act gat aca tac gcc tgc aga gtt aag cat gcc agt atg      337
 Pro Thr Glu Thr Asp Thr Tyr Ala Cys Arg Val Lys His Ala Ser Met
              95                 100                 105

 gcc gag ccc aag acc gtc tac tgg gat cga gac atg tga tcaagcatca       386
 Ala Glu Pro Lys Thr Val Tyr Trp Asp Arg Asp Met 
         110                 115

 tgatgctctg aagattcatt ggaacctgct tagttacaat ccagtttcta atatgctata    446

 caatttatgc acgcagaaag aaatagcaat ggacacatca ccttctttat atcttacttt    506

 aaatattgga tgcatgtgtt gaaaagaatg gaaatatgcg tgatagctga gcgatagatc    566

 tgcatgagta tttggatcag agtataatgt gatttaagga catagtgatc ttacatagaa    626

 gagaaaggaa ccgtgtccga atgtgggcct gaggcgaaat cctataggag cgaatcatcg    686

 gaatctgtat agcgtggcgg ggaatagtat agcgtacatt gcaaaagat                735




      <210> 90
      <211> 804
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (200)..(631)

      <400> 90
 ctcctgcggc gcatgcgtcg cgcccaaacg aggccggctg tggagaaagg caggcaacgc     60

 atgcgtagtt gatgtaggga gtcggcggtg agaaatggac agcccgcatt gaccgaagct    120

 ttgcgcatgc gttttactgc tgggtgaagc cgaacctcgg gagcccagga cgccctcctg    180

 cacatgcgca ggaggctca atg aca gtc gag ctt tgg cta agg ctc cgg gga     232
                      Met Thr Val Glu Leu Trp Leu Arg Leu Arg Gly
                        1               5                  10

 aag ggt cta gcc atg ctg cat gtg acc cgg ggg gtc tgg ggg tcc agg      280
 Lys Gly Leu Ala Met Leu His Val Thr Arg Gly Val Trp Gly Ser Arg
              15                  20                  25

 gtc cga gta tgg cca ctg ttg ccc gcg ctc ctc ggg ccc ccc cgg gcc      328
 Val Arg Val Trp Pro Leu Leu Pro Ala Leu Leu Gly Pro Pro Arg Ala
          30                  35                  40

 ctc tca tcg ctg gca gcc aaa atg ggg gag tat cgc aag atg tgg aac      376
 Leu Ser Ser Leu Ala Ala Lys Met Gly Glu Tyr Arg Lys Met Trp Asn
      45                  50                  55

 ccc agg gag ccc cgc gac tgg gcc cag cag tac cgc gag cgc ttc att      424
 Pro Arg Glu Pro Arg Asp Trp Ala Gln Gln Tyr Arg Glu Arg Phe Ile
  60                  65                  70                  75

 ccc ttc tcc aag gag cag ctg ctc cgc ctc cta ata cag gta aca gga      472
 Pro Phe Ser Lys Glu Gln Leu Leu Arg Leu Leu Ile Gln Val Thr Gly
                  80                  85                  90

 att cca ctc gag tcc ggc aga gaa ggc ggc ttt gga ggc gtt ctc ggc      520
 Ile Pro Leu Glu Ser Gly Arg Glu Gly Gly Phe Gly Gly Val Leu Gly
              95                 100                 105

 cca cgt gga ctt ctg cac cct gtt cca cta cca cca aat cct ggc ccg      568
 Pro Arg Gly Leu Leu His Pro Val Pro Leu Pro Pro Asn Pro Gly Pro
         110                 115                 120

 gct gca ggt gag gac ggg gcc ctt cca gcc ctg tgg tgc ttg ttc gag      616
 Ala Ala Gly Glu Asp Gly Ala Leu Pro Ala Leu Trp Cys Leu Phe Glu
     125                 130                 135

 cat ccg ctc att tag caaacattcc ctgacacctt cttggagcct ggcccttatt      671
 His Pro Leu Ile 
 140

 ttaagtgctg gggattcaat agtgaacatg acaggtgaag tgacgccctc atggagccaa    731

 cattccaagt ggggaggcaa ggaatcaaat aaatataaaa tatgaaaaaa aaaaaaaaaa    791

 aaaaaaaaga tct                                                       804




      <210> 91
      <211> 1337
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (58)..(1188)

      <400> 91
 gtcctcctcc cgctcggaag gtcccaggtg tgacaccttc agcaggtctc agggaag        57                                                                 
 atg gca gcc cta ggg gac att cag gag tcc cct tct gtc ccg tcc cct      105
 Met Ala Ala Leu Gly Asp Ile Gln Glu Ser Pro Ser Val Pro Ser Pro
   1               5                  10                  15

 gtc agt ctc tca tca ccg ggg aca cct gga acc cag cac cac gag cct      153
 Val Ser Leu Ser Ser Pro Gly Thr Pro Gly Thr Gln His His Glu Pro
              20                  25                  30

 cag ctt cac ctc cat ggg cat caa cat ggc tcc cct ggc tcc agc cct      201
 Gln Leu His Leu His Gly His Gln His Gly Ser Pro Gly Ser Ser Pro
          35                  40                  45

 aag gtg ctc tcc cag ccg tcc gac ctg gat ctc caa gac gta gag gaa      249
 Lys Val Leu Ser Gln Pro Ser Asp Leu Asp Leu Gln Asp Val Glu Glu
      50                  55                  60

 gtg gag atc ggc aga gac acc ttc tgg ccc gac tcc gag ccc aag ccg      297
 Val Glu Ile Gly Arg Asp Thr Phe Trp Pro Asp Ser Glu Pro Lys Pro
  65                  70                  75                  80

 gag cag gct cca cgc tct cct ggc tct cag gcc cct gac gag ggg gcg      345
 Glu Gln Ala Pro Arg Ser Pro Gly Ser Gln Ala Pro Asp Glu Gly Ala
                  85                  90                  95

 ggc ggg gcg ctg cgc agc ctc ctg agg agc ctt ccc cgc agg gcc cgg      393
 Gly Gly Ala Leu Arg Ser Leu Leu Arg Ser Leu Pro Arg Arg Ala Arg
             100                 105                 110

 tgc agc gcc ggc ttc ggg cct gaa tcc agc gcg gag cgg ccg gcg ggc      441
 Cys Ser Ala Gly Phe Gly Pro Glu Ser Ser Ala Glu Arg Pro Ala Gly
         115                 120                 125

 cag ccg cct ggg gcc gtc cct tgc gcc cag ccg cgg ggc gcc tgg cgc      489
 Gln Pro Pro Gly Ala Val Pro Cys Ala Gln Pro Arg Gly Ala Trp Arg
     130                 135                 140

 gtg acg ctc gtg cag caa gca gcg gct ggg ccc gag ggt gcg ccc gag      537
 Val Thr Leu Val Gln Gln Ala Ala Ala Gly Pro Glu Gly Ala Pro Glu
 145                 150                 155                 160

 cgg gct gcc gag ctg gga gtc aac ttc ggt cgg agc cgg cag ggc agc      585
 Arg Ala Ala Glu Leu Gly Val Asn Phe Gly Arg Ser Arg Gln Gly Ser
                 165                 170                 175

 gcg cgg ggg gcc aag ccg cac agg tgc gag gcc tgc ggc aag agt ttc      633
 Ala Arg Gly Ala Lys Pro His Arg Cys Glu Ala Cys Gly Lys Ser Phe
             180                 185                 190

 aag tat aac tcg ctg ctc ctg aag cac cag cgc atc cac acg ggc gag      681
 Lys Tyr Asn Ser Leu Leu Leu Lys His Gln Arg Ile His Thr Gly Glu
         195                 200                 205

 aag ccc tac gcc tgc cac gag tgc ggc aag cgc ttc cgc ggc tgg tcg      729
 Lys Pro Tyr Ala Cys His Glu Cys Gly Lys Arg Phe Arg Gly Trp Ser
     210                 215                 220

 ggc ttc atc cag cac cac cgc atc cac acg ggc gag aag ccc tac gag      777
 Gly Phe Ile Gln His His Arg Ile His Thr Gly Glu Lys Pro Tyr Glu
 225                 230                 235                 240

 tgc ggc cag tgc ggc cgc gcc ttc agc cac agc tcg cac ttc acg cag      825
 Cys Gly Gln Cys Gly Arg Ala Phe Ser His Ser Ser His Phe Thr Gln
                 245                 250                 255

 cac ctg cgc atc cac aac ggc gag aag ccc tac aag tgc ggc gag tgc      873
 His Leu Arg Ile His Asn Gly Glu Lys Pro Tyr Lys Cys Gly Glu Cys
             260                 265                 270

 ggc cag gcc ttc agc cag agc tcc aac ctg gtg cgc cac cag cgg ctg      921
 Gly Gln Ala Phe Ser Gln Ser Ser Asn Leu Val Arg His Gln Arg Leu
         275                 280                 285

 cac acg ggt gag aag ccc tac gcc tgc agc cag tgc ggc aag gcc ttc      969
 His Thr Gly Glu Lys Pro Tyr Ala Cys Ser Gln Cys Gly Lys Ala Phe
     290                 295                 300

 atc tgg agc tcc gtg ctc atc gag cac cag cgc atc cac act ggc gag     1017
 Ile Trp Ser Ser Val Leu Ile Glu His Gln Arg Ile His Thr Gly Glu
 305                 310                 315                 320

 aag ccc tac gag tgc tcc gac tgc ggc aaa gcc ttc cgc ggc cgc tcg     1065
 Lys Pro Tyr Glu Cys Ser Asp Cys Gly Lys Ala Phe Arg Gly Arg Ser
                 325                 330                 335

 cac ttc ttc cgg cac ctg cgg acc cac acg ggc gag aag ccc ttc gcg     1113
 His Phe Phe Arg His Leu Arg Thr His Thr Gly Glu Lys Pro Phe Ala
             340                 345                 350

 tgt ggc gcc tgc ggc aag gcc ttc ggc cag agc tcc cag ctc atc cag     1161
 Cys Gly Ala Cys Gly Lys Ala Phe Gly Gln Ser Ser Gln Leu Ile Gln
         355                 360                 365

 cac cag cgg gtg cac tac cgc gag tag ccggg cgggggctcg gggctcggcc     1213
 His Gln Arg Val His Tyr Arg Glu 
     370                 375

 tcctacctgc ccccaaccca ccctccaccc cgtcccccac ggtgggcact gcccagcacc   1273

 gcatgccacg tgtccggaat aaattctttt tgattgttgg aagtgggaaa aaaaaaaaaa   1333

 aaac                                                                1337




      <210> 92
      <211> 2343
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (202)..(2343)

      <400> 92
 ctcagcaatg ggcatcagac ttccgactgg ccaatcataa taccccgttc ctcgggccat     60

 aataattggt tcatcatcca aagggaccca gtcagagtct tccccgagat gagtatatgg    120

 ggttattagg cagaatataa gtttgagact gtgggtagcc acgttgattg ctacttggaa    180

 aggtctgtag acaaaacgaa g  atg ggg gag tgt atc ctg ctg ctg cca caa     231
                          Met Gly Glu Cys Ile Leu Leu Leu Pro Gln
                            1               5                  10

 tgc aca acc aca aac gtg gtg gct tat gac aac agc cat cag ttc tct      279
 Cys Thr Thr Thr Asn Val Val Ala Tyr Asp Asn Ser His Gln Phe Ser
                  15                  20                  25

 cat gat tct gga cca gag tct aaa acc aag ctt cgt ttt gtc tac aga      327
 His Asp Ser Gly Pro Glu Ser Lys Thr Lys Leu Arg Phe Val Tyr Arg
              30                  35                  40

 cct ttc caa gta gca atc aac gtg gct acc cac agt ctc aaa ctt ata      375
 Pro Phe Gln Val Ala Ile Asn Val Ala Thr His Ser Leu Lys Leu Ile
          45                  50                  55

 ttc tgc cta ata acc cca tat act cat ctc ggg gaa gac tct gac tgg      423
 Phe Cys Leu Ile Thr Pro Tyr Thr His Leu Gly Glu Asp Ser Asp Trp
      60                  65                  70

 gtc cct ttg gat gat gaa cca att att atg gcc cga gga acg ggg tat      471
 Val Pro Leu Asp Asp Glu Pro Ile Ile Met Ala Arg Gly Thr Gly Tyr
  75                  80                  85                  90

 tat gat tgg cca gtc gga agt ctg atg ccc att gct gag gaa gcc cac      519
 Tyr Asp Trp Pro Val Gly Ser Leu Met Pro Ile Ala Glu Glu Ala His
                  95                 100                 105

 ttg gag tct tat agt cca gag ttc ttg aag aga gct ggt cac gta tgc      567
 Leu Glu Ser Tyr Ser Pro Glu Phe Leu Lys Arg Ala Gly His Val Cys
             110                 115                 120

 aca tac ctg cta cat gaa cag agt gag aac tcc aat cca gac tcg gag      615
 Thr Tyr Leu Leu His Glu Gln Ser Glu Asn Ser Asn Pro Asp Ser Glu
         125                 130                 135

 aca agc tct gtg act att cga gag aca cct cga aaa aag agc att tct      663
 Thr Ser Ser Val Thr Ile Arg Glu Thr Pro Arg Lys Lys Ser Ile Ser
     140                 145                 150

 gaa gat tca gct tcc cca gta gag gga cct tta agg gcc atg ctt gga      711
 Glu Asp Ser Ala Ser Pro Val Glu Gly Pro Leu Arg Ala Met Leu Gly
 155                 160                 165                 170

 gat gcc cag gtg ggg aaa ctc ttg gca tgt cac tat cgg tcg gag gac      759
 Asp Ala Gln Val Gly Lys Leu Leu Ala Cys His Tyr Arg Ser Glu Asp
                 175                 180                 185

 gca aga aag cag gag agg cat ttg agg tgt tta ttt gct act ccc aag      807
 Ala Arg Lys Gln Glu Arg His Leu Arg Cys Leu Phe Ala Thr Pro Lys
             190                 195                 200

 gga gac acc tca ggg gag aga ggc ctt ggg tgt aac gag ctt ggg aga      855
 Gly Asp Thr Ser Gly Glu Arg Gly Leu Gly Cys Asn Glu Leu Gly Arg
         205                 210                 215

 agc ctc cgg cag gcc tct gcc ctc atc agg aag caa cga gtg ccc ttt      903
 Ser Leu Arg Gln Ala Ser Ala Leu Ile Arg Lys Gln Arg Val Pro Phe
     220                 225                 230

 gga gac aga ccc cgg aag tgg ggc agg ccc tgg aag agc ttg aaa cgc      951
 Gly Asp Arg Pro Arg Lys Trp Gly Arg Pro Trp Lys Ser Leu Lys Arg
 235                 240                 245                 250

 caa agg acg ttc gtg gag aag aaa cca ttt aac tgc acg gaa tgt ggg      999
 Gln Arg Thr Phe Val Glu Lys Lys Pro Phe Asn Cys Thr Glu Cys Gly
                 255                 260                 265

 aaa gcc ttc att tac cat tcg gac tat att ctc cat cag cga att cac     1047
 Lys Ala Phe Ile Tyr His Ser Asp Tyr Ile Leu His Gln Arg Ile His
             270                 275                 280

 acc agg gag aag ccc cac agg att cac act gga gag aag ccc tac aaa     1095
 Thr Arg Glu Lys Pro His Arg Ile His Thr Gly Glu Lys Pro Tyr Lys
         285                 290                 295

 ggc aag gac tgc ggg aag gcc ttc aca cag agc tca tcc ctc atc aaa     1143
 Gly Lys Asp Cys Gly Lys Ala Phe Thr Gln Ser Ser Ser Leu Ile Lys
     300                 305                 310

 cac cag cgg tgc cac acc ggg gag aag ccc tat aaa tgc ggc cag tgt     1191
 His Gln Arg Cys His Thr Gly Glu Lys Pro Tyr Lys Cys Gly Gln Cys
 315                 320                 325                 330

 ggg aag ttc tac tcg cag gtc tcc cac ctc acc cgc cac cag aaa atc     1239
 Gly Lys Phe Tyr Ser Gln Val Ser His Leu Thr Arg His Gln Lys Ile
                 335                 340                 345

 cac acg ggg gag aag ccc tac caa tgt gga gag tgc ggc aag gcc ttc     1287
 His Thr Gly Glu Lys Pro Tyr Gln Cys Gly Glu Cys Gly Lys Ala Phe
             350                 355                 360

 tgt cac acc tcc tcc ctg acc caa cac cag acc acc cac acg ggg gag     1335
 Cys His Thr Ser Ser Leu Thr Gln His Gln Thr Thr His Thr Gly Glu
         365                 370                 375

 aaa ccc tac aaa tgt aac aag tgt ggg aaa acg ttc agc cac agc tca     1383
 Lys Pro Tyr Lys Cys Asn Lys Cys Gly Lys Thr Phe Ser His Ser Ser
     380                 385                 390

 tcc ctg act gag cac cag cga gtc cac act gga gaa aaa ccc tat gag     1431
 Ser Leu Thr Glu His Gln Arg Val His Thr Gly Glu Lys Pro Tyr Glu
 395                 400                 405                 410

 tgc act gat tgt ggc aaa gcc ttc agc cac agc tcg tcc ctg acc cag     1479
 Cys Thr Asp Cys Gly Lys Ala Phe Ser His Ser Ser Ser Leu Thr Gln
                 415                 420                 425

 cat cag cga att cac act ggc gag aag ccc tac gcg tgt cac gag tgc     1527
 His Gln Arg Ile His Thr Gly Glu Lys Pro Tyr Ala Cys His Glu Cys
             430                 435                 440

 ggg aag gct tac acg cag att tcc cac ctc atg agg cac cag agc act     1575
 Gly Lys Ala Tyr Thr Gln Ile Ser His Leu Met Arg His Gln Ser Thr
         445                 450                 455

 cac gtg ggg gaa aag ccc tat gta tgc aac gaa tgt ggg aag gct ttc     1623
 His Val Gly Glu Lys Pro Tyr Val Cys Asn Glu Cys Gly Lys Ala Phe
     460                 465                 470

 agc cac acc tca tcc ttt act cag cac cag acc atc cac acc ggt gag     1671
 Ser His Thr Ser Ser Phe Thr Gln His Gln Thr Ile His Thr Gly Glu
 475                 480                 485                 490

 aag ccc tac aaa tgt aca gag tgt ggg aaa acc ttc agc cag aac tcc     1719
 Lys Pro Tyr Lys Cys Thr Glu Cys Gly Lys Thr Phe Ser Gln Asn Ser
                 495                 500                 505

 tcc ctc aca cac cac cag agg att cac aca ggg gag aaa ccc tat gaa     1767
 Ser Leu Thr His His Gln Arg Ile His Thr Gly Glu Lys Pro Tyr Glu
             510                 515                 520

 tgt aaa gtg tgt ggg aaa gcc tat acc cag atc tcc cac ctc att caa     1815
 Cys Lys Val Cys Gly Lys Ala Tyr Thr Gln Ile Ser His Leu Ile Gln
         525                 530                 535

 cac cag agg att cac act gga gag agg ccc tac gag ggc aga gag tgt     1863
 His Gln Arg Ile His Thr Gly Glu Arg Pro Tyr Glu Gly Arg Glu Cys
     540                 545                 550

 ggg aaa gcc ttc agc cag agc acg cac ctc att gag cac cag aag atc     1911
 Gly Lys Ala Phe Ser Gln Ser Thr His Leu Ile Glu His Gln Lys Ile
 555                 560                 565                 570

 cac act ggc gag aag ccc tat aag tgt aag gaa tgt ggg aaa acc ttc     1959
 His Thr Gly Glu Lys Pro Tyr Lys Cys Lys Glu Cys Gly Lys Thr Phe
                 575                 580                 585

 agt cac aac tca tcc ctc act caa cat cag aag att cac acc ggc gag     2007
 Ser His Asn Ser Ser Leu Thr Gln His Gln Lys Ile His Thr Gly Glu
             590                 595                 600

 aag ccc tac gcc tgc aag gaa tgt ggg aag gcc ttc aac cag agc atc     2055
 Lys Pro Tyr Ala Cys Lys Glu Cys Gly Lys Ala Phe Asn Gln Ser Ile
         605                 610                 615

 cac tta atc caa cac caa agg att cac act gga gag aag cct tac aag     2103
 His Leu Ile Gln His Gln Arg Ile His Thr Gly Glu Lys Pro Tyr Lys
     620                 625                 630

 tgt agt gac tgt ggg aga acc tat acc cag atc tca cac ctt ctc caa     2151
 Cys Ser Asp Cys Gly Arg Thr Tyr Thr Gln Ile Ser His Leu Leu Gln
 635                 640                 645                 650

 cat cag aag gtc cac act ggc agc aaa cgc tac aca tgt gag gag tgt     2199
 His Gln Lys Val His Thr Gly Ser Lys Arg Tyr Thr Cys Glu Glu Cys
                 655                 660                 665

 gga gag ggt ttc agc tgg agt tca cac ctg act gaa cac cag agg ctt     2247
 Gly Glu Gly Phe Ser Trp Ser Ser His Leu Thr Glu His Gln Arg Leu
             670                 675                 680

 cat act ggc cag aat gcc tac atc tgt gat gat ttt gag aaa gcc ttt     2295
 His Thr Gly Gln Asn Ala Tyr Ile Cys Asp Asp Phe Glu Lys Ala Phe
         685                 690                 695

 gct tgg ggc aca cag ctt gct gat cat cag aga acc cat gct gat tag     2343
 Ala Trp Gly Thr Gln Leu Ala Asp His Gln Arg Thr His Ala Asp 
     700                 705                 710





      <210> 93
      <211> 399
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (1)..(399)

      <400> 93
  atg gat ctg gcc cag atg cac gcc tgt caa gga cct gga aat gac ctt      48
  Met Asp Leu Ala Gln Met His Ala Cys Gln Gly Pro Gly Asn Asp Leu
    1               5                  10                  15

 tac att gaa gca tct gct gct ctg tgt gca ggc tct gat ttc agt gtg       96
 Tyr Ile Glu Ala Ser Ala Ala Leu Cys Ala Gly Ser Asp Phe Ser Val
              20                  25                  30

 tca gga gga ctg cag tgg gtc cag ctt gta gct cat gga agt gct ggt      144
 Ser Gly Gly Leu Gln Trp Val Gln Leu Val Ala His Gly Ser Ala Gly
          35                  40                  45

 gat gat aat ggc tgg ctc agg tgc cac agg cct cca tgg caa ggt tta      192
 Asp Asp Asn Gly Trp Leu Arg Cys His Arg Pro Pro Trp Gln Gly Leu
      50                  55                  60

 gga gac aat gaa ctc gat ggt tgc agt gga gaa gtc aat gtc agc cag      240
 Gly Asp Asn Glu Leu Asp Gly Cys Ser Gly Glu Val Asn Val Ser Gln
  65                  70                  75                  80

 gat ttc gtt aag act ctt tta agg att tgc aac gct atc cca tca ttt      288
 Asp Phe Val Lys Thr Leu Leu Arg Ile Cys Asn Ala Ile Pro Ser Phe
                  85                  90                  95

 cgc ggg tta cta gag tcc tgc atg ttt ggc tgt aga gca agg gtg acg      336
 Arg Gly Leu Leu Glu Ser Cys Met Phe Gly Cys Arg Ala Arg Val Thr
             100                 105                 110

 cgt aac ttc tgg act ttg gtt cca tct aca tct gcc gga tgc gga tgc      384
 Arg Asn Phe Trp Thr Leu Val Pro Ser Thr Ser Ala Gly Cys Gly Cys
         115                 120                 125

 cag tcg caa cag taa                                                  399
 Gln Ser Gln Gln 
     130





      <210> 94
      <211> 2677
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (833)..(1246)

      <400> 94
 ttttggggtt ttagcggtta accccagcac gatctgcatc acctgaaaga caaaggaccc     60

 aagatcccgg ctcctagttg gacctgccac tgcagggatt aagccgctaa aaccccgaaa    120

 aagagaggga gaggtagaga gagagagaaa gaaagaagag aagagaagag aagagcaaga    180

 gaacaaggag aagaaagagg aggagaagga gaaagaagaa gaggcaggag gaggagaaaa    240

 gagaagggaa aggaaggaga ggagagccgg cccatcctga gtttggccca gaggaaagga    300

 tggactcagg gctccactga ttgggactct gcatggtcag tggctcctcc acaccccttc    360

 agcccagagc ctcccctccc caggctctta ctgagaaggc cagagaatca catcgctaag    420

 taagaagaca taactggctc ggtgtcctgt tcagagggag gctggcagag agtgctgctg    480

 cggctggagg tggggagttc ctcccgccgc cccacgaggc aggccgtcac actcacccat    540

 gaggccacca gcagccggct gctgcccctg gcctgggtgg cccggggccg cagcgcagag    600

 cagcaggtga gcaggagctt ggccagggca gactcctggt ggatgtgcac atcgatgtgg    660

 gtgtgctgtg gggcctccgg ggccatctca tcactgtcgg ctgttcacat tgtcagggac    720

 acagtctatg aggaagggag caccagagag gaacggctgt cagaagattt tcgcagattt    780

 cattggagtt ggggaggtca ggggccagtg gtggctcaaa gtcacccaat ga    atg     835
                                                              Met
                                                                1

 gct gta ctg gtc aca ggg ccg cac ccc tgg ccc ctc acg agg gga atg      883
 Ala Val Leu Val Thr Gly Pro His Pro Trp Pro Leu Thr Arg Gly Met
               5                  10                  15

 tgt gta gca gag ggg ctg ctg acc atg ctg gaa ctg cgg cga cta ctg      931
 Cys Val Ala Glu Gly Leu Leu Thr Met Leu Glu Leu Arg Arg Leu Leu
          20                  25                  30

 agc ctg cgg gaa cct ccc ctt tcg ccc aag atc tgc tct gtc ccc ctc      979
 Ser Leu Arg Glu Pro Pro Leu Ser Pro Lys Ile Cys Ser Val Pro Leu
      35                  40                  45

 atc ctc ctc cca ggg ccc tgg cgt ctg ggt caa gca gcg ccc cac acc     1027
 Ile Leu Leu Pro Gly Pro Trp Arg Leu Gly Gln Ala Ala Pro His Thr
  50                  55                  60                  65

 tcg acc cct cac ccc ctc ctc ccg ggc tct tcc tgc ggc ctc ccc tcc     1075
 Ser Thr Pro His Pro Leu Leu Pro Gly Ser Ser Cys Gly Leu Pro Ser
                  70                  75                  80

 aca gtc cgc agg ctc tgg gac agg acc gag tcc ttg gct gcc tgt gga     1123
 Thr Val Arg Arg Leu Trp Asp Arg Thr Glu Ser Leu Ala Ala Cys Gly
              85                  90                  95

 gct cct gtg cca gca gct gcg ccc cgg ctg cgc tcc gga tac ccc cat     1171
 Ala Pro Val Pro Ala Ala Ala Pro Arg Leu Arg Ser Gly Tyr Pro His
         100                 105                 110

 ccc cgc cac cgc cga cct ccc gct cca ccg act gct gct cac gcc cga     1219
 Pro Arg His Arg Arg Pro Pro Ala Pro Pro Thr Ala Ala His Ala Arg
     115                 120                 125

 cgg gtt cac gcc gcc cct gcc ccg tga aggac cgcgctgcgg tgcggaggca     1271
 Arg Val His Ala Ala Pro Ala Pro 
 130                 135

 cggatgacgc aaaacacggt gattgtgaat ggagttgcta tggcctctag gccatcccag   1331

 cccacccacg tcaacgtcca catccaccag gagtcagctt tgacacaact gctgaaagct   1391

 ggaggttctc tgaagaagtt tctttttcac cctggggaca ctgtgccttc cacagccagg   1451

 attggttatg agcagctggc tctaggggtg actcagatat tgctgggggt tgtgagttgt   1511

 gttcttggag tgtgtctcag cttggggccc tggactgtgc tgcgtgcctc aggctgtgcc   1571

 ttctgggcgg ggtctgtggt gatcgcagca ggagctgggg ccattgtcca tgagaagcac   1631

 ccgggcaaac ttgctggcta tatatccagc ctgctcaccc tgacaggctt tgctacagct   1691

 atggctgctg ttgtcctctg cgtgaatagc ttcatctggc aaactgaacc ctttttatac   1751

 atcgacactg tgtgtgatcg ctcagaccct gtcttcccta ccactgggta cagatggatg   1811

 cggcgaagtc aagagaacca atggcagaag gaggagtgta gagcttacat gcagatgctg   1871

 aggaagttgt tcacagcaat ccgtgccctg ttcctggctg tctgtgtctt gaaggtcatt   1931

 gtgtccttgg tttccttggg agtaggtctt cgaaacttgt gtggccagag ctcccagccc   1991

 ctgaatgagg aaggatcaga gaagaggcta ctgggggaga attcagtgcc cccttcgccc   2051

 tctagggagc agacctccac tgccattgtc ctgtgagctg ccaaagaccc cacggggtgc   2111

 ccgcatgtcc ctgtctaggg cagcccaggg cccccactcc tggctcctca cacttgcctc   2171

 ccctatggcc gctctccaga ccctcctcct ttcttctccc cacatccgca cctgctgttc   2231

 ccactctggg gttctcaagt ccatgaacag atattgttgc attttccaca atgctgatta   2291

 aacataataa acaatccaga aaagcagttt tgccctgtta agagcagaaa cattcaactg   2351

 acatgcaggt atacgcacaa ctatctaaaa atgagagtcg gatcaagatt ctcacggcgg   2411

 ttgttgagct acgagataca cgagcccggg ctctagggga ggacctcgga gccgatatgg   2471

 cttataacga agctcttgaa cagtagtggt gcaggcttac catgaggaga cctgctaaac   2531

 cccggagggt gacaaactta gatgtgttaa gaaagcatcc tttttctgat aacggcagca   2591

 tttaaaaaca ggtcagacct ccgtgcctat cccacatgtt tccacccatc atgggcaatg   2651

 gcacatggta tgcgtatata ttgggg                                        2677




      <210> 95
      <211> 873
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (90)..(338)

      <400> 95
 atgtcactct gcttgctgat gaactggacg ctcgtggtgg cccccgggca actggcactc     60

 acaggctgga agagtgggtc ttctaatga  atg cct cga ggg tcc tct gtg cgc     113
                                  Met Pro Arg Gly Ser Ser Val Arg
                                    1               5

 tgc cac ctg cat ggc cac cat cta cag tca aca ggg ttt atg gtt ctt      161
 Cys His Leu His Gly His His Leu Gln Ser Thr Gly Phe Met Val Leu
      10                  15                  20

 ctc cac ctt gga ggc agc aga gaa agg gac ctt ggt agt ggt tgt ggc      209
 Leu His Leu Gly Gly Ser Arg Glu Arg Asp Leu Gly Ser Gly Cys Gly
  25                  30                  35                  40

 caa ggg tct ttt act tgt ctc ctg ggg gct cca ccc cag aga gat gca      257
 Gln Gly Ser Phe Thr Cys Leu Leu Gly Ala Pro Pro Gln Arg Asp Ala
                  45                  50                  55

 ggt cgg caa tca ctc agt gca atc agc cca gaa tgg agg gtc tgt gct      305
 Gly Arg Gln Ser Leu Ser Ala Ile Ser Pro Glu Trp Arg Val Cys Ala
              60                  65                  70

 gtg ggc cca agt cac agg ttt cct gtc cgg tga tgagcagt gggaggtgtt      356
 Val Gly Pro Ser His Arg Phe Pro Val Arg 
          75                  80

 tgggacccag gggagacaga ttggcctcat ctccttgggt cagctgcagc ttgttggagc    416

 tcagactctc caaagcccaa aaactagaga gctaagtcac ccaaatggca aagagggcag    476

 tccactcctt ctcctgggag ttccatctca gggaggagta accctgccta ctggtggctg    536

 gctggaattc caagccaggg ggtcttatcc tgtgaggtgc catggaagtg gggtctgcag    596

 actgtcgctg ctcagccccc cggattcagc atctttccta gggactacaa caattccaca    656

 tgaagatgat gctggcacaa agcttccaac ccattctgtc ttcttaccca gaaaacaaaa    716

 acatcctggt gttgggcccc ttacatcagg tatccagaga ttttttactc ctccaataga    776

 aggagtaaga gtctatgccc atagaatcag caagaagcag ttacagaaga tggacgtctt    836

 cccttctgcg gtccccttaa gattaaggag tctctaa                             873




      <210> 96
      <211> 1963
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (180)..(1916)

      <400> 96
 cacggaaata gtaggagtcg gtcccgggtt taatttcatg acgggggtgt ccgtttcccg     60

 tgtaggctag tagggcagtt gctgcgacca gtgacgcaga gtctgcggac ccggcgccga    120

 ggcggccacc cgagacgcgg ctgcgcgacg ctccgggcct gcgcagccct ggcccggcc     179                                                                 
 atg gcg gcc ccc cgc ccg tct ccc gcg atc tcc gtt tcg gtc tcg gct      227
 Met Ala Ala Pro Arg Pro Ser Pro Ala Ile Ser Val Ser Val Ser Ala
   1               5                  10                  15

 ccg gct ttt tac tgc ccc gca gaa gaa gtt cgg ccc tgt ggt ggc ccc      275
 Pro Ala Phe Tyr Cys Pro Ala Glu Glu Val Arg Pro Cys Gly Gly Pro
              20                  25                  30

 aaa gcc caa agt gaa tcc ctt ccg ggc ccg ggg gac agc gag cct ccc      323
 Lys Ala Gln Ser Glu Ser Leu Pro Gly Pro Gly Asp Ser Glu Pro Pro
          35                  40                  45

 ccg gca ccc ggg ggc cca gcg cgc aca gat ggg ccg ggt ggg cga gat      371
 Pro Ala Pro Gly Gly Pro Ala Arg Thr Asp Gly Pro Gly Gly Arg Asp
      50                  55                  60

 tcc ccg cgg ccg ccc cgc gga aga ctt tcc gcc gtg tcc tcc acc tcg      419
 Ser Pro Arg Pro Pro Arg Gly Arg Leu Ser Ala Val Ser Ser Thr Ser
  65                  70                  75                  80

 ccc ttg ctg ggg gat ggc gac gat gca gag cgg tgc ctc tgg gag gtg      467
 Pro Leu Leu Gly Asp Gly Asp Asp Ala Glu Arg Cys Leu Trp Glu Val
                  85                  90                  95

 ccc ttc ccg ccg ccc cct ccc ccg atc gag gaa tca ttt ccc cct gcg      515
 Pro Phe Pro Pro Pro Pro Pro Pro Ile Glu Glu Ser Phe Pro Pro Ala
             100                 105                 110

 cct ctg gag gag gag atc ttc cct tcc ccg ccg cct cct ccg gag gag      563
 Pro Leu Glu Glu Glu Ile Phe Pro Ser Pro Pro Pro Pro Pro Glu Glu
         115                 120                 125

 gag gga ggg cct gag gcc ccc ata ccg ccc cca cca cag ccc agg gag      611
 Glu Gly Gly Pro Glu Ala Pro Ile Pro Pro Pro Pro Gln Pro Arg Glu
     130                 135                 140

 aag gtg agc agt att gat ttg gag atc gac tct ctg tcc tca ctg ctg      659
 Lys Val Ser Ser Ile Asp Leu Glu Ile Asp Ser Leu Ser Ser Leu Leu
 145                 150                 155                 160

 gat gac atg acc aag aat gat cct ttc aaa gcc cgg gtg tca tct gga      707
 Asp Asp Met Thr Lys Asn Asp Pro Phe Lys Ala Arg Val Ser Ser Gly
                 165                 170                 175

 tat gtg ccc cca cca gtg gcc act cca ttc agt tcc aag tcc agt acc      755
 Tyr Val Pro Pro Pro Val Ala Thr Pro Phe Ser Ser Lys Ser Ser Thr
             180                 185                 190

 aag cct gca gcc ggg ggc aca gca ccc ctg cct cct tgg aag tcc cct      803
 Lys Pro Ala Ala Gly Gly Thr Ala Pro Leu Pro Pro Trp Lys Ser Pro
         195                 200                 205

 tcc agc tcc cag cct ctg ccc cag gtt ccg gct ccg gct cag agc cag      851
 Ser Ser Ser Gln Pro Leu Pro Gln Val Pro Ala Pro Ala Gln Ser Gln
     210                 215                 220

 aca cag ttc cat gtt cag ccc cag ccc cag ccc aag cct cag gtc caa      899
 Thr Gln Phe His Val Gln Pro Gln Pro Gln Pro Lys Pro Gln Val Gln
 225                 230                 235                 240

 ctc cat gtc cag tcc cag acc cag cct gtg tct ttg gct aac acc cag      947
 Leu His Val Gln Ser Gln Thr Gln Pro Val Ser Leu Ala Asn Thr Gln
                 245                 250                 255

 ccc cga ggg ccc cca gcc tca tct ccg gct cca gcc cct aag ttt tct      995
 Pro Arg Gly Pro Pro Ala Ser Ser Pro Ala Pro Ala Pro Lys Phe Ser
             260                 265                 270

 cca gtg act cct aag ttt act cct gtg gct tcc aag ttc agt cct gga     1043
 Pro Val Thr Pro Lys Phe Thr Pro Val Ala Ser Lys Phe Ser Pro Gly
         275                 280                 285

 gcc cca ggt gga tct ggg tca caa cca aat caa aaa ttg ggg cac ccc     1091
 Ala Pro Gly Gly Ser Gly Ser Gln Pro Asn Gln Lys Leu Gly His Pro
     290                 295                 300

 gaa gct ctt tct gct ggc aca ggc tcc cct caa cct ccc agc ttc acc     1139
 Glu Ala Leu Ser Ala Gly Thr Gly Ser Pro Gln Pro Pro Ser Phe Thr
 305                 310                 315                 320

 tat gcc cag cag agg gag aag ccc cga gtg cag gag aag cag cac ccc     1187
 Tyr Ala Gln Gln Arg Glu Lys Pro Arg Val Gln Glu Lys Gln His Pro
                 325                 330                 335

 gtg ccc cca ccg gct cag aac caa aac cag gtg cgc tcc ccc tgg agg     1235
 Val Pro Pro Pro Ala Gln Asn Gln Asn Gln Val Arg Ser Pro Trp Arg
             340                 345                 350

 ccc cag ggg ccc ctg act ctg aag gag gtg gag gag ctg gag cag ctg     1283
 Pro Gln Gly Pro Leu Thr Leu Lys Glu Val Glu Glu Leu Glu Gln Leu
         355                 360                 365

 acc cag cag cta atg cag gac atg gag cat cct cag agg cag aat gtg     1331
 Thr Gln Gln Leu Met Gln Asp Met Glu His Pro Gln Arg Gln Asn Val
     370                 375                 380

 gct gtc aac gaa ctc tgc ggc cga tgc cat caa ccc ctg gcc cgg gcg     1379
 Ala Val Asn Glu Leu Cys Gly Arg Cys His Gln Pro Leu Ala Arg Ala
 385                 390                 395                 400

 cag cca gcc gtc cgc gct cta ggg cag ctg ttc cac atc gcc tgc ttc     1427
 Gln Pro Ala Val Arg Ala Leu Gly Gln Leu Phe His Ile Ala Cys Phe
                 405                 410                 415

 acc tgc cac cag tgt gcg cag cag ctc cag ggc cag cag ttc tac agt     1475
 Thr Cys His Gln Cys Ala Gln Gln Leu Gln Gly Gln Gln Phe Tyr Ser
             420                 425                 430

 ctg gag ggg gcg ccg tac tgc gag ggc tgt tac act gac acc ctg gag     1523
 Leu Glu Gly Ala Pro Tyr Cys Glu Gly Cys Tyr Thr Asp Thr Leu Glu
         435                 440                 445

 aag tgt aac acc tgc ggg gag ccc atc act gac cgc atg ctg agg gcc     1571
 Lys Cys Asn Thr Cys Gly Glu Pro Ile Thr Asp Arg Met Leu Arg Ala
     450                 455                 460

 acg ggc aag gcc tat cac ccg cac tgc ttc acc tgt gtg gtc tgc gcc     1619
 Thr Gly Lys Ala Tyr His Pro His Cys Phe Thr Cys Val Val Cys Ala
 465                 470                 475                 480

 cgc ccc ctg gag ggc acc tcc ttc atc gtg gac cag gcc aac cgg ccc     1667
 Arg Pro Leu Glu Gly Thr Ser Phe Ile Val Asp Gln Ala Asn Arg Pro
                 485                 490                 495

 cac tgt gtc ccc gac tac cac aag cag tac gcc ccg agg tgc tcc gtc     1715
 His Cys Val Pro Asp Tyr His Lys Gln Tyr Ala Pro Arg Cys Ser Val
             500                 505                 510

 tgc tct gag ccc atc atg cct gag cct ggc cga gat gag act gtg cga     1763
 Cys Ser Glu Pro Ile Met Pro Glu Pro Gly Arg Asp Glu Thr Val Arg
         515                 520                 525

 gtg gtc gcc ctg gac aag aac ttc cac atg aag tgt tac aag tgt gag     1811
 Val Val Ala Leu Asp Lys Asn Phe His Met Lys Cys Tyr Lys Cys Glu
     530                 535                 540

 gac tgc ggg aag ccc ctg tcg att gag gca gat gac aat ggc tgc ttc     1859
 Asp Cys Gly Lys Pro Leu Ser Ile Glu Ala Asp Asp Asn Gly Cys Phe
 545                 550                 555                 560

 ccc ctg gac ggt cac gtg ctc tgt cgg aag tgc cac act gct aga gcc     1907
 Pro Leu Asp Gly His Val Leu Cys Arg Lys Cys His Thr Ala Arg Ala
                 565                 570                 575

 cag acc tga gtgagga caggccctct tcagaccgca gtccatgccc cattgtggac     1963
 Gln Thr 






      <210> 97
      <211> 507
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (1)..(507)

      <400> 97
  atg ata aaa tgt atg tct tca aga ttt gaa gac aat ggc ata agg tca      48
  Met Ile Lys Cys Met Ser Ser Arg Phe Glu Asp Asn Gly Ile Arg Ser
    1               5                  10                  15

 gtg atc cag ctg ctt gta ccc ctg act ttt tct gac cct gga gaa ggg       96
 Val Ile Gln Leu Leu Val Pro Leu Thr Phe Ser Asp Pro Gly Glu Gly
              20                  25                  30

 agc act ggc ttt gct ttc atc agg cca aag atg cct ttc ttt ggg aat      144
 Ser Thr Gly Phe Ala Phe Ile Arg Pro Lys Met Pro Phe Phe Gly Asn
          35                  40                  45

 acg ttc agt ccg aag aag aca cct cct cgg aag tcg gca tct ctc tcc      192
 Thr Phe Ser Pro Lys Lys Thr Pro Pro Arg Lys Ser Ala Ser Leu Ser
      50                  55                  60

 aac ctg cat tct ttg gat cga tca acc cgg gag gtg gag ctg ggc ttg      240
 Asn Leu His Ser Leu Asp Arg Ser Thr Arg Glu Val Glu Leu Gly Leu
  65                  70                  75                  80

 gaa tac gga tcc ccg act atg aac ctg gca ggg caa agc ctg aag ttt      288
 Glu Tyr Gly Ser Pro Thr Met Asn Leu Ala Gly Gln Ser Leu Lys Phe
                  85                  90                  95

 gaa aat ggc cag tgg ata gca gag aca ggg gtt agt ggc ggt gtg gac      336
 Glu Asn Gly Gln Trp Ile Ala Glu Thr Gly Val Ser Gly Gly Val Asp
             100                 105                 110

 cgg agg gag gtt cag cgc ctt cgc agg cgg aac cag cag ttg gag gaa      384
 Arg Arg Glu Val Gln Arg Leu Arg Arg Arg Asn Gln Gln Leu Glu Glu
         115                 120                 125

 gag aac aat ctc ttg cgg ctg aaa gtg gac atc tta tta gac atg ctt      432
 Glu Asn Asn Leu Leu Arg Leu Lys Val Asp Ile Leu Leu Asp Met Leu
     130                 135                 140

 tca gag tcc act gct gaa tcc cac tta atg gag aag gaa ctg gat gaa      480
 Ser Glu Ser Thr Ala Glu Ser His Leu Met Glu Lys Glu Leu Asp Glu
 145                 150                 155                 160

 ctg agg atc agc cgg aag aga aaa tga                                  507
 Leu Arg Ile Ser Arg Lys Arg Lys 
                 165





      <210> 98
      <211> 1006
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (471)..(860)

      <400> 98
 caccactcct atagatcagt caagagtctt ggggacctct ctgctacacc gataaatcca     60

 tggcttcccc acttgagagg gctcccagtg ggtcactgcc caagataaac tcagcttcca    120

 gcatagagaa ataaaagctg actcattggt tgtgatgtct cctgatacca tgtgtaggaa    180

 gtgaactgtc tgaccaggca gttctggact cctccagaac ccgcttcctg caaccacaca    240

 gcacgcaggt aacattatcc cgtgtgaccc acgcccacag gcaggcccgg atgcaggcac    300

 agctaagact ggccataacc tatcgagagt cctggccaat cagctgtgac ctgctgtcca    360

 agtgcattgt gaccccaggt cggaatgagt tctttatgca gacataatga gcagtcctgg    420

 ctggagcctc ctgtgccccc accacaccaa gcactctgcg aggcccgccc   atg tct     476
                                                          Met Ser
                                                            1

 tct ggc tgc ctc ctg agt gtg ctt cac cca ccc tgg cct ggt ctt ccc      524
 Ser Gly Cys Leu Leu Ser Val Leu His Pro Pro Trp Pro Gly Leu Pro
           5                  10                  15

 ttc cac ctc cac ctt tcc ttt gct tct ttt ccc ccc agg gtc aga gcc      572
 Phe His Leu His Leu Ser Phe Ala Ser Phe Pro Pro Arg Val Arg Ala
      20                  25                  30

 tct aag cct ccc cca tca ttt ggc aat gta ggc tcc aaa gag ggt acc      620
 Ser Lys Pro Pro Pro Ser Phe Gly Asn Val Gly Ser Lys Glu Gly Thr
  35                  40                  45                  50

 cta aga ggg cag act cca gcc cca cag aac tgg gct ccg agc cct ggc      668
 Leu Arg Gly Gln Thr Pro Ala Pro Gln Asn Trp Ala Pro Ser Pro Gly
                  55                  60                  65

 caa gaa gcc aga agg cac ata acc cct ctg tcc att cac ttc cac cag      716
 Gln Glu Ala Arg Arg His Ile Thr Pro Leu Ser Ile His Phe His Gln
              70                  75                  80

 gct cca ctc agg gtt ccc ctt ctt gtc ctg ggc ctc cag gat ggt cac      764
 Ala Pro Leu Arg Val Pro Leu Leu Val Leu Gly Leu Gln Asp Gly His
          85                  90                  95

 agg ctg gcc tgc ctg cag gct cac ttc atg gct gct tct ggc cac aaa      812
 Arg Leu Ala Cys Leu Gln Ala His Phe Met Ala Ala Ser Gly His Lys
     100                 105                 110

 agg gta cgc ggc tat gac ctg gtt cat ggt ggg aat aga ggg cac tag      860
 Arg Val Arg Gly Tyr Asp Leu Val His Gly Gly Asn Arg Gly His 
 115                 120                 125

 agctgggctg ggctccggtg ttagacatcg ggggtctttg ttcagccccg cctgccttct    920

 gagctcctct gcactgggga ccacatggta cagctgtagt ttcccagccg gcacataccc    980

 acgatgtccc ccggtgtcca ccagcc                                        1006




      <210> 99
      <211> 888
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (211)..(792)

      <400> 99
 ggtactgagg gccaaggtgt tggaagttcc taattctttc ctcggttaac tgtgaaactc     60

 tgcgtattgg gaaggcctgg cctcagtcat caggccagga gaggtactgg acgccgcgca    120

 cgcactcgtc tgccagcgag gcccaaaggg gaagcctagc ggagctcagt gtggcagctg    180

 ctggcctctg ggccgctact tgtcaatacc     atg ctt tcc tgt aat att tgt     231
                                      Met Leu Ser Cys Asn Ile Cys
                                        1               5

 ggt gaa aca gta acc tca gaa cca gac atg aaa gct cac cta att gtt      279
 Gly Glu Thr Val Thr Ser Glu Pro Asp Met Lys Ala His Leu Ile Val
          10                  15                  20

 cac atg gaa agt gaa att ata tgt cca ttt tgc aag ttg tca ggt gtg      327
 His Met Glu Ser Glu Ile Ile Cys Pro Phe Cys Lys Leu Ser Gly Val
      25                  30                  35

 aat tat gat gaa atg tgt ttt cat atc gaa aca gct cat ttt gag cag      375
 Asn Tyr Asp Glu Met Cys Phe His Ile Glu Thr Ala His Phe Glu Gln
  40                  45                  50                  55

 aat aca ctt gaa aga aac ttt gag agg ata aat aca gta caa tat gga      423
 Asn Thr Leu Glu Arg Asn Phe Glu Arg Ile Asn Thr Val Gln Tyr Gly
                  60                  65                  70

 act tca gat aac aag aaa gac aac acc cta cag tgt gga atg gaa gtt      471
 Thr Ser Asp Asn Lys Lys Asp Asn Thr Leu Gln Cys Gly Met Glu Val
              75                  80                  85

 aat tca agt att ctt tca ggt tgt gca tct aat cat cca aaa aat tca      519
 Asn Ser Ser Ile Leu Ser Gly Cys Ala Ser Asn His Pro Lys Asn Ser
          90                  95                 100

 gct caa aac ctg act aaa gat agt act tta aaa cat gaa ggc ttc tat      567
 Ala Gln Asn Leu Thr Lys Asp Ser Thr Leu Lys His Glu Gly Phe Tyr
     105                 110                 115

 tca gag aac tta act gaa tct aga aaa ttc ctg aaa agt agg gaa aaa      615
 Ser Glu Asn Leu Thr Glu Ser Arg Lys Phe Leu Lys Ser Arg Glu Lys
 120                 125                 130                 135

 cag tcc agc ctg acc gaa ata aaa gga tct gtt tat gaa aca aca tac      663
 Gln Ser Ser Leu Thr Glu Ile Lys Gly Ser Val Tyr Glu Thr Thr Tyr
                 140                 145                 150

 agt cct cct gaa tgt cca ttc tgt gga aaa ata gag gag cac agt gaa      711
 Ser Pro Pro Glu Cys Pro Phe Cys Gly Lys Ile Glu Glu His Ser Glu
             155                 160                 165

 gat atg gaa act cat gtg aaa aca aag cat gcc aat ctt tta gac att      759
 Asp Met Glu Thr His Val Lys Thr Lys His Ala Asn Leu Leu Asp Ile
         170                 175                 180

 cca ttg gaa ggt aaa gtt ttc att tca tta taa attataag tttacagcct      810
 Pro Leu Glu Gly Lys Val Phe Ile Ser Leu 
     185                 190

 caatttaata tgtggtattt taaaagttgg tttgtaagtc agcttactac agatgtgttt    870

 tgaaatccat tttatgtc                                                  888




      <210> 100
      <211> 408
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (99)..(368)

      <220>
      <221> misc_feature
      <222> (1)...(408)
      <223> n = a,t,c or g

      <400> 100
 ccgctccgga attcccgggt cgacgatttc gtcctcactt catccggcga cntatgcatc     60

 cgcgtcccgg cagcgccagc cctacactcg cccgcgcc    atg gcc tct gtc tcc     113
                                              Met Ala Ser Val Ser
                                                1               5

 gag ctc gcc tgc atc tac tcg gcc ctc att ctg cac gac gat gag gtg      161
 Glu Leu Ala Cys Ile Tyr Ser Ala Leu Ile Leu His Asp Asp Glu Val
                  10                  15                  20

 aca gtc acg gcc ctg gcc aac gtc aac att ggg agc ctc atc tgc aat      209
 Thr Val Thr Ala Leu Ala Asn Val Asn Ile Gly Ser Leu Ile Cys Asn
              25                  30                  35

 gta ggg gcc ggt gga cct gct cca gca gct ggt gct gca cca gca gga      257
 Val Gly Ala Gly Gly Pro Ala Pro Ala Ala Gly Ala Ala Pro Ala Gly
          40                  45                  50

 ggt cct gcc ccc tcc act gct gct gct cca gct gag gag aag aaa gtg      305
 Gly Pro Ala Pro Ser Thr Ala Ala Ala Pro Ala Glu Glu Lys Lys Val
      55                  60                  65

 gaa gca aag aaa gaa gaa tcc gag gag tct gat gat gac atg ggc ttt      353
 Glu Ala Lys Lys Glu Glu Ser Glu Glu Ser Asp Asp Asp Met Gly Phe
  70                  75                  80                  85

 ggt ctt ttt gac taa acctctttta taacatgttc aataaaaagc tgaactttaa      408
 Gly Leu Phe Asp 






      <210> 101
      <211> 666
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (1)..(666)

      <400> 101
  atg gcg gct gcg tcg ggg tcg gtt ctg cag cgc tgt atc gtg tcg ccg      48
  Met Ala Ala Ala Ser Gly Ser Val Leu Gln Arg Cys Ile Val Ser Pro
    1               5                  10                  15

 gca ggg agg cat agc gcc tct ctg atc ttc ctg cat ggc tca ggt gat       96
 Ala Gly Arg His Ser Ala Ser Leu Ile Phe Leu His Gly Ser Gly Asp
              20                  25                  30

 tct gga caa gga tta aga atg tgg atc aag cag gtt tta aat caa gat      144
 Ser Gly Gln Gly Leu Arg Met Trp Ile Lys Gln Val Leu Asn Gln Asp
          35                  40                  45

 tta aca ttc caa cac ata aaa att att tat cca aca gct cct ccc aga      192
 Leu Thr Phe Gln His Ile Lys Ile Ile Tyr Pro Thr Ala Pro Pro Arg
      50                  55                  60

 ttt aaa ata acc aat gac tgc cca gaa cac ctt gaa tca att gat gtc      240
 Phe Lys Ile Thr Asn Asp Cys Pro Glu His Leu Glu Ser Ile Asp Val
  65                  70                  75                  80

 atg tgt caa gtg ctt act gat ttg att gat gaa gaa gta aaa agt ggc      288
 Met Cys Gln Val Leu Thr Asp Leu Ile Asp Glu Glu Val Lys Ser Gly
                  85                  90                  95

 atc aag aag aac agg ata tta ata gga gga ttc tct atg gga gga tgc      336
 Ile Lys Lys Asn Arg Ile Leu Ile Gly Gly Phe Ser Met Gly Gly Cys
             100                 105                 110

 atg gca atg cat tta gca tat aga aat cat caa gat gtg gca gga gta      384
 Met Ala Met His Leu Ala Tyr Arg Asn His Gln Asp Val Ala Gly Val
         115                 120                 125

 ttt gct ctt tct agt ttt ctg aat aaa gca tct gct gtt tac cag gct      432
 Phe Ala Leu Ser Ser Phe Leu Asn Lys Ala Ser Ala Val Tyr Gln Ala
     130                 135                 140

 ctt cag aag agt aat ggt gta ctt cct gaa tta ttt cag tgt cat ggt      480
 Leu Gln Lys Ser Asn Gly Val Leu Pro Glu Leu Phe Gln Cys His Gly
 145                 150                 155                 160

 act gca gat gag tta gtt ctt cat tct tgg gca gaa gag aca aac tca      528
 Thr Ala Asp Glu Leu Val Leu His Ser Trp Ala Glu Glu Thr Asn Ser
                 165                 170                 175

 atg tta aaa tct cta gga gtg acc acg aag ttt cat agt ttt cca aat      576
 Met Leu Lys Ser Leu Gly Val Thr Thr Lys Phe His Ser Phe Pro Asn
             180                 185                 190

 gtt tac cat gag cta agc aaa act gag tta gac ata ttg aag tta tgg      624
 Val Tyr His Glu Leu Ser Lys Thr Glu Leu Asp Ile Leu Lys Leu Trp
         195                 200                 205

 att ctt aca aag ctg cca gga gaa atg gaa aaa caa aaa tga              666
 Ile Leu Thr Lys Leu Pro Gly Glu Met Glu Lys Gln Lys 
     210                 215                 220





      <210> 102
      <211> 1576
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (57)..(647)

      <400> 102
 aacagtatat tacacaaggt cgagctcctg ttttcaattt cagttaccgg gcgggt         56                                                                 
 atg tcg tgt act tca cag gga ctg tcg cga gca tca tat ttc cgg gct      104
 Met Ser Cys Thr Ser Gln Gly Leu Ser Arg Ala Ser Tyr Phe Arg Ala
   1               5                  10                  15

 ggg gtc tgc gcg gcc ctg gag gcc tgg ccg gcc ttg cag atc gct gtg      152
 Gly Val Cys Ala Ala Leu Glu Ala Trp Pro Ala Leu Gln Ile Ala Val
              20                  25                  30

 gag aat ggc ttc ggg ggt gtg cac agc cag gag aag gcc aag tgg ctg      200
 Glu Asn Gly Phe Gly Gly Val His Ser Gln Glu Lys Ala Lys Trp Leu
          35                  40                  45

 ggg ggt gca gtg gag gat tac ttc atg cgc aat gct gac ttg gag cta      248
 Gly Gly Ala Val Glu Asp Tyr Phe Met Arg Asn Ala Asp Leu Glu Leu
      50                  55                  60

 gat gag gtg gaa gac ttc ctt gga gag ctg ttg acc aac gag ttt gat      296
 Asp Glu Val Glu Asp Phe Leu Gly Glu Leu Leu Thr Asn Glu Phe Asp
  65                  70                  75                  80

 aca gtt gtg gaa gac ggg agt ctg ccc cag gtg agc cag caa ctg cag      344
 Thr Val Val Glu Asp Gly Ser Leu Pro Gln Val Ser Gln Gln Leu Gln
                  85                  90                  95

 acc atg ttc cac cac ttc cag agg ggt gat ggg gct gct ctg agg gag      392
 Thr Met Phe His His Phe Gln Arg Gly Asp Gly Ala Ala Leu Arg Glu
             100                 105                 110

 atg gcc tcc tgc atc act cag aga aaa tgc aag gtc aca gcc act gca      440
 Met Ala Ser Cys Ile Thr Gln Arg Lys Cys Lys Val Thr Ala Thr Ala
         115                 120                 125

 ctt aag aca gct aga gag act gat gag gat gaa gat gat gtg gac agt      488
 Leu Lys Thr Ala Arg Glu Thr Asp Glu Asp Glu Asp Asp Val Asp Ser
     130                 135                 140

 gtg gaa gag atg gag gtc aca gct acg aat gat ggg gct gct aca gat      536
 Val Glu Glu Met Glu Val Thr Ala Thr Asn Asp Gly Ala Ala Thr Asp
 145                 150                 155                 160

 ggg gtc tgc ccc cag cct gaa ccc tct gat cca gac gct cag act att      584
 Gly Val Cys Pro Gln Pro Glu Pro Ser Asp Pro Asp Ala Gln Thr Ile
                 165                 170                 175

 aag gaa gag gat ata gtg gaa gat ggc tgg acc att tcc gga gaa aaa      632
 Lys Glu Glu Asp Ile Val Glu Asp Gly Trp Thr Ile Ser Gly Glu Lys
             180                 185                 190

 aat gag tgg gga tga ttggaaatgg ctttgggccc ttatttgctg ttctaagagt      687
 Asn Glu Trp Gly 
         195

 tgtctgtagg ggtttttttt ttgaggattg cagacctgtg gactggttac cccatctcca    747

 ccctctcccc tgttcctctg tctggctccc tccagggcaa ggaaaaccta gggtccttgg    807

 tcttgggggt ggggggacct tttccagcat attcccctgg gcctttagtt aacatccgag    867

 tgacgaagcc gggttcccca gtacagtgtc ttttgggtgc ggtcattgtg aggaagggga    927

 tgagtgagtg tgggtgtggc tggaggagga gctagatgcc ggtggacagt gggcaggtgg    987

 atttggggag gagaggatca gcagcagcag cagtactcag tgataggggg ctggctgggt   1047

 caggaatggt gagatgaaca tgcaagtgga agagagaata gttgaaaatg tgaatgaaag   1107

 tagctctgga gcctctccct taccccaccc cacacacacg caacagctct gtacccctgc   1167

 ccagaacttg gaacctccca ggaatgctgc cttccttcag cccagcctcc cagtcctggg   1227

 ttccctcagg aattcgaaga ccttggctag gtggtgagct tggaagagct gggctttgtt   1287

 ttctgtctcc tctaacctct ttccttactc cttatcccat cccatttgag ttcaggggtg   1347

 aggcttaaga tcttaataaa taatacctta ctgcttaatc tgtggcttga cctgtgagta   1407

 gtagccttag aatcagcctt ctgggagctc agcttcagag tttacaaggg agcagtttct   1467

 gggcccaccc tagcagcctg gtactttgga cacccaaaca gatgagcgag cggagcacag   1527

 cagtgctatg aaagttactg taagcctgaa aataaactgg tatttttct               1576




      <210> 103
      <211> 597
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (1)..(597)

      <400> 103
  atg agc acg gtg gac ctt gct cgc gtg ggc gcg tgc atc ctg aag cat      48
  Met Ser Thr Val Asp Leu Ala Arg Val Gly Ala Cys Ile Leu Lys His
    1               5                  10                  15

 gcg gtg acc ggg gag gcc gtg gag ctg cgg agc ctg tgg cgg gag cac       96
 Ala Val Thr Gly Glu Ala Val Glu Leu Arg Ser Leu Trp Arg Glu His
              20                  25                  30

 gcg tgc gtg gtg gcc ggg ctg cgg cgc ttc ggg tgc gtg gtg tgc cgc      144
 Ala Cys Val Val Ala Gly Leu Arg Arg Phe Gly Cys Val Val Cys Arg
          35                  40                  45

 tgg atc gcc cag gac ctc agc agc ctt gct ggg ctc ctg gac caa cac      192
 Trp Ile Ala Gln Asp Leu Ser Ser Leu Ala Gly Leu Leu Asp Gln His
      50                  55                  60

 ggc gtg cgc ctg gtg ggc gta ggg ccc gag gcc ctg ggt ctg cag gag      240
 Gly Val Arg Leu Val Gly Val Gly Pro Glu Ala Leu Gly Leu Gln Glu
  65                  70                  75                  80

 ttc ctg gac ggc gac tac ttc gcg gga gag ctc tac ctg gat gag agc      288
 Phe Leu Asp Gly Asp Tyr Phe Ala Gly Glu Leu Tyr Leu Asp Glu Ser
                  85                  90                  95

 aag cag ctt tac aag gag cta ggc ttc aag cgg tac aac agc ctg agc      336
 Lys Gln Leu Tyr Lys Glu Leu Gly Phe Lys Arg Tyr Asn Ser Leu Ser
             100                 105                 110

 atc ctc cca gca gct ctg ggg aag ccc gtg cgt gat gtg gct gcc aag      384
 Ile Leu Pro Ala Ala Leu Gly Lys Pro Val Arg Asp Val Ala Ala Lys
         115                 120                 125

 gcc aag gct gtt ggc atc cag ggg aac ttg tct ggg gac ctg ctg cag      432
 Ala Lys Ala Val Gly Ile Gln Gly Asn Leu Ser Gly Asp Leu Leu Gln
     130                 135                 140

 agc gga ggg ctg ctg gtg gtc agc aaa ggt ggt gat aaa gtg ctc ctg      480
 Ser Gly Gly Leu Leu Val Val Ser Lys Gly Gly Asp Lys Val Leu Leu
 145                 150                 155                 160

 cat ttc gtc cag aag tcc cca ggc gac tac gtc ccc aag gag cac atc      528
 His Phe Val Gln Lys Ser Pro Gly Asp Tyr Val Pro Lys Glu His Ile
                 165                 170                 175

 ctg cag gtc ctg ggc atc tct gcg gag gtc tgt gcc agc gac ccg cct      576
 Leu Gln Val Leu Gly Ile Ser Ala Glu Val Cys Ala Ser Asp Pro Pro
             180                 185                 190

 cag tgt gac aga gag gtg tga                                          597
 Gln Cys Asp Arg Glu Val 
         195





      <210> 104
      <211> 365
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (38)..(358)

      <400> 104
 tctttaatat ttacccctgg ttggaacaat atttgaa atg tcc cag ata ttt cta      55
                                          Met Ser Gln Ile Phe Leu
                                            1               5

 tgc tac tta gat att tgt ggc aaa gca gaa agc ttt ttg act gtg aag      103
 Cys Tyr Leu Asp Ile Cys Gly Lys Ala Glu Ser Phe Leu Thr Val Lys
              10                  15                  20

 gca gag gtc agc act ggg gga aac ttg ctg gtg gtc tct ccc aca acc      151
 Ala Glu Val Ser Thr Gly Gly Asn Leu Leu Val Val Ser Pro Thr Thr
          25                  30                  35

 ttg ccc aga gtc ctt tcc act aag gag gtg aag aga aca gag aaa gag      199
 Leu Pro Arg Val Leu Ser Thr Lys Glu Val Lys Arg Thr Glu Lys Glu
      40                  45                  50

 att tcc att tct gct gcc aga gct ggt att tgc ctg cct gat tct ctg      247
 Ile Ser Ile Ser Ala Ala Arg Ala Gly Ile Cys Leu Pro Asp Ser Leu
  55                  60                  65                  70

 tgt ttc ctg ttt cac cgc cac cct ttc agg aga gaa cta cac cag ttc      295
 Cys Phe Leu Phe His Arg His Pro Phe Arg Arg Glu Leu His Gln Phe
                  75                  80                  85

 atc atg agg gtc agg gaa gca aaa gct ctc aga tgt gtc cag ggt att      343
 Ile Met Arg Val Arg Glu Ala Lys Ala Leu Arg Cys Val Gln Gly Ile
              90                  95                 100

 gaa tca tgg tgc tag ctctctc                                          365
 Glu Ser Trp Cys 
         105





      <210> 105
      <211> 1384
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (475)..(1236)

      <400> 105
 atgggagaag catttgcaca ggagaacatg gcagagaacc cttatatttc tgtagtcaat     60

 tctcatattt taaacaattg ggaatttccc aaatggtcac tcgatgattc tacaaaggta    120

 caactcaact cgatgaagct gggtggaaca gaaatggctc cgcggcgttg gcagctcgtc    180

 tgcgagggga ccctggctcc ccgaggctgc agtccttttt cttggacaga acgccccgca    240

 ggaccgttcc ctccactttc ccccgcacta aggcagcgca ccgccagcac acacagcgct    300

 ggcgcccgca tcgcgccgca ccacacgcgt ctccggcttg aggagccagt caccgagacc    360

 cggagcggga acgagatcct tccgcccggt gaggaagccc ggggtggctg ctccgccgtc    420

 ggggccgcgc cgccgagccc cagccgcccc gggccgcccc cgcacgccgc cccc  atg     477
                                                              Met
                                                                1

 cat ccc ttc tac acc cgg gcc gcc acc atg ata ggc gag atc gcc gcc      525
 His Pro Phe Tyr Thr Arg Ala Ala Thr Met Ile Gly Glu Ile Ala Ala
               5                  10                  15

 gcc gtg tcc ttc atc tcc aag ttt ctc cgc acc aag ggg ctc acg agc      573
 Ala Val Ser Phe Ile Ser Lys Phe Leu Arg Thr Lys Gly Leu Thr Ser
          20                  25                  30

 gag cga cag ctg cag acc ttc agc cag agc ctg cag gag ctg ctg gca      621
 Glu Arg Gln Leu Gln Thr Phe Ser Gln Ser Leu Gln Glu Leu Leu Ala
      35                  40                  45

 ggt gag cag ggc gag ggc gtc gga ggg acg cgg gcc cca cat ccc tgg      669
 Gly Glu Gln Gly Glu Gly Val Gly Gly Thr Arg Ala Pro His Pro Trp
  50                  55                  60                  65

 gtc aga gtc cgg ccg tcg ggg ctg cgg gaa cct cgg cag cgc ccc ggg      717
 Val Arg Val Arg Pro Ser Gly Leu Arg Glu Pro Arg Gln Arg Pro Gly
                  70                  75                  80

 gcc ggt cgc gct tgg gcc ccg ccg cgg gac cgc tgg caa aac gga gag      765
 Ala Gly Arg Ala Trp Ala Pro Pro Arg Asp Arg Trp Gln Asn Gly Glu
              85                  90                  95

 gag aag aca aca cgc aca aca aag aaa ctt aag ccc acc gag gcg gga      813
 Glu Lys Thr Thr Arg Thr Thr Lys Lys Leu Lys Pro Thr Glu Ala Gly
         100                 105                 110

 gct gcg gtc cga gga ccg tcg gcg gat ttg ggg aca aag gag ccg tgg      861
 Ala Ala Val Arg Gly Pro Ser Ala Asp Leu Gly Thr Lys Glu Pro Trp
     115                 120                 125

 ggc tgg gaa cat tat aaa cat cac tgg ttc ccg gaa aag cca tgc aag      909
 Gly Trp Glu His Tyr Lys His His Trp Phe Pro Glu Lys Pro Cys Lys
 130                 135                 140                 145

 gga tcg ggt tac cgt tgt att cgc atc aac cat aaa atg gat cct ctg      957
 Gly Ser Gly Tyr Arg Cys Ile Arg Ile Asn His Lys Met Asp Pro Leu
                 150                 155                 160

 att gga cag gca gca cag cgg att gga ctg agc agt cag gag ctg ttc     1005
 Ile Gly Gln Ala Ala Gln Arg Ile Gly Leu Ser Ser Gln Glu Leu Phe
             165                 170                 175

 agg ctt ctc cca agt gaa ctc aca ctc tgg gtt gac ccc tat gaa gtg     1053
 Arg Leu Leu Pro Ser Glu Leu Thr Leu Trp Val Asp Pro Tyr Glu Val
         180                 185                 190

 tcc tac aga att gga gag gat ggc tcc atc tgt gtg ctg tat gaa gcc     1101
 Ser Tyr Arg Ile Gly Glu Asp Gly Ser Ile Cys Val Leu Tyr Glu Ala
     195                 200                 205

 tca cca gca gga ggt agc act caa aac agc acc aac gtg caa atg gta     1149
 Ser Pro Ala Gly Gly Ser Thr Gln Asn Ser Thr Asn Val Gln Met Val
 210                 215                 220                 225

 gac agc cga atc agc tgt aag gag gaa ctt ctc ttg ggc aga acg agc     1197
 Asp Ser Arg Ile Ser Cys Lys Glu Glu Leu Leu Leu Gly Arg Thr Ser
                 230                 235                 240

 cct tcc aaa aac tac aat atg atg act gta tca ggt taa gatatagtct      1246
 Pro Ser Lys Asn Tyr Asn Met Met Thr Val Ser Gly 
             245                 250

 gtggatggat catctgatga tgatggataa atttgatttt tgctttgggt gggctcctct   1306

 tggggatgga ttatggaatt taaaccatgt cacagctgtg aagatctggc acaagataga   1366

 atggtaaaaa aaaaaaaa                                                 1384




      <210> 106
      <211> 2092
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (338)..(2038)

      <220>
      <221> misc_feature
      <222> (1)...(2092)
      <223> n = a,t,c or g

      <400> 106
 agaggcgcgg annccnnnna atgatnacat tgtagacatt cgncagngcg gnggaattca     60

 cagcatctct gccttcctgt tcacggtgac cttcgcttgg tgtccttctg gcctcagcaa    120

 cctgacaatt ctgtcgtgtc ccgagagatg gctaatgaat ggcgcttgat gacagatgag    180

 taatgcctgt tgctgaaaga ttgacggtat gaggcaagac tcccactact acttaatcaa    240

 gaggaattga gattgactta cccataagtt cagacagtgt ctcgaagaga ctttgggaac    300

 aagatattca ggcacatttc actgttagac tcacagg atg ctg gcc att ggt ctt     355
                                          Met Leu Ala Ile Gly Leu
                                            1               5

 tcc ctt tgt gat cat ctt tct caa gat gtt ttc tgt ctt cat gag tca      403
 Ser Leu Cys Asp His Leu Ser Gln Asp Val Phe Cys Leu His Glu Ser
              10                  15                  20

 aaa ttt gaa gag gaa agg atg gtg gct ggg tgg ttg aca aat tac tct      451
 Lys Phe Glu Glu Glu Arg Met Val Ala Gly Trp Leu Thr Asn Tyr Ser
          25                  30                  35

 cag gac tca gtg acc ttt gag gat gtg gct gtg gac ttc acc cag gag      499
 Gln Asp Ser Val Thr Phe Glu Asp Val Ala Val Asp Phe Thr Gln Glu
      40                  45                  50

 gag tgg act ttg ctg gat caa act cag aga aac tta tac aga gat gtg      547
 Glu Trp Thr Leu Leu Asp Gln Thr Gln Arg Asn Leu Tyr Arg Asp Val
  55                  60                  65                  70

 atg ctg gag aac tat aag aat cta gtt gca gta gat tgg gag agt cat      595
 Met Leu Glu Asn Tyr Lys Asn Leu Val Ala Val Asp Trp Glu Ser His
                  75                  80                  85

 att aat acc aaa tgg tca gca cct cag cag aat ttt ttg cag ggg aaa      643
 Ile Asn Thr Lys Trp Ser Ala Pro Gln Gln Asn Phe Leu Gln Gly Lys
              90                  95                 100

 aca tcc agt gtg gtg gaa atg gag aga aac cat ttt gga gag gaa ctg      691
 Thr Ser Ser Val Val Glu Met Glu Arg Asn His Phe Gly Glu Glu Leu
         105                 110                 115

 ttt gac ttt aac caa tgt gaa aaa gcc ttg agt gaa cac tca tgc ctt      739
 Phe Asp Phe Asn Gln Cys Glu Lys Ala Leu Ser Glu His Ser Cys Leu
     120                 125                 130

 aag act cac agg aga act tac ttt aga aag aaa acc tgt gag tgt aat      787
 Lys Thr His Arg Arg Thr Tyr Phe Arg Lys Lys Thr Cys Glu Cys Asn
 135                 140                 145                 150

 caa tgt gaa aaa gcc ttc aga aaa ccc tct atc ttt act tta cac aag      835
 Gln Cys Glu Lys Ala Phe Arg Lys Pro Ser Ile Phe Thr Leu His Lys
                 155                 160                 165

 aaa act gat atc gga gag gaa ctt cct aac tgt aat caa tgt gaa aca      883
 Lys Thr Asp Ile Gly Glu Glu Leu Pro Asn Cys Asn Gln Cys Glu Thr
             170                 175                 180

 gcc ttc agc caa cat cta cat ctt gtt tgc aag aaa act agc caa aat      931
 Ala Phe Ser Gln His Leu His Leu Val Cys Lys Lys Thr Ser Gln Asn
         185                 190                 195

 cta cat ctt gtt tgc aag aaa act cac act caa gag aaa cca tat aaa      979
 Leu His Leu Val Cys Lys Lys Thr His Thr Gln Glu Lys Pro Tyr Lys
     200                 205                 210

 tgc agt gac tgt gaa aaa ggc tta cct tcc tcc tca cac ctc aga gaa     1027
 Cys Ser Asp Cys Glu Lys Gly Leu Pro Ser Ser Ser His Leu Arg Glu
 215                 220                 225                 230

 tgt gta aga att tat ggt gga gag aga cca tat act cat aag gag tat     1075
 Cys Val Arg Ile Tyr Gly Gly Glu Arg Pro Tyr Thr His Lys Glu Tyr
                 235                 240                 245

 gtc gaa acc ttt tct cat tct aca gcc ctt ttt gta cac atg caa act     1123
 Val Glu Thr Phe Ser His Ser Thr Ala Leu Phe Val His Met Gln Thr
             250                 255                 260

 caa gat gga gaa aaa ttc tat gaa tgt aaa gca tgt ggg aaa ccc ttc     1171
 Gln Asp Gly Glu Lys Phe Tyr Glu Cys Lys Ala Cys Gly Lys Pro Phe
         265                 270                 275

 act gag tcg tca tat ctt act caa cat tta aga act cat agt aga gtg     1219
 Thr Glu Ser Ser Tyr Leu Thr Gln His Leu Arg Thr His Ser Arg Val
     280                 285                 290

 tta cct ata gaa cat aag aaa ttt ggc aaa gcc ttt gct ttt tcc cca     1267
 Leu Pro Ile Glu His Lys Lys Phe Gly Lys Ala Phe Ala Phe Ser Pro
 295                 300                 305                 310

 gat ctt gct aaa cat ata aga ctt aga act aga gga aaa cac tat gtt     1315
 Asp Leu Ala Lys His Ile Arg Leu Arg Thr Arg Gly Lys His Tyr Val
                 315                 320                 325

 tgt aat gaa tgt ggc aaa gaa ttt act tgt ttc tca aaa ctc aac att     1363
 Cys Asn Glu Cys Gly Lys Glu Phe Thr Cys Phe Ser Lys Leu Asn Ile
             330                 335                 340

 cac ata agg gtt cac act gga gaa aaa ccg tat gag tgc aac aaa tgt     1411
 His Ile Arg Val His Thr Gly Glu Lys Pro Tyr Glu Cys Asn Lys Cys
         345                 350                 355

 ggg aaa gcc ttc act gat tca tca ggt ctt ata aaa cac agg cga act     1459
 Gly Lys Ala Phe Thr Asp Ser Ser Gly Leu Ile Lys His Arg Arg Thr
     360                 365                 370

 cac act gga gaa aag cct tat gaa tgt aag gaa tgt ggg aaa gct ttt     1507
 His Thr Gly Glu Lys Pro Tyr Glu Cys Lys Glu Cys Gly Lys Ala Phe
 375                 380                 385                 390

 gct aac tct tca cat ctt act gta cat atg aga act cac act ggt gag     1555
 Ala Asn Ser Ser His Leu Thr Val His Met Arg Thr His Thr Gly Glu
                 395                 400                 405

 aag cct tat caa tgt aag gaa tgt gga aaa gcc ttt att aat tcc tct     1603
 Lys Pro Tyr Gln Cys Lys Glu Cys Gly Lys Ala Phe Ile Asn Ser Ser
             410                 415                 420

 tcc ttt aaa agt cac atg cag act cat cct ggt gta aaa ccc tat gac     1651
 Ser Phe Lys Ser His Met Gln Thr His Pro Gly Val Lys Pro Tyr Asp
         425                 430                 435

 tgt caa cag tgt ggg aaa gcc ttc att cga tcc tca ttt ctt att cga     1699
 Cys Gln Gln Cys Gly Lys Ala Phe Ile Arg Ser Ser Phe Leu Ile Arg
     440                 445                 450

 cat ttg aga agt cac agt gca gaa agg cct ttt gaa tgt gag gaa tgt     1747
 His Leu Arg Ser His Ser Ala Glu Arg Pro Phe Glu Cys Glu Glu Cys
 455                 460                 465                 470

 ggg aaa gcc ttt aga tac tcc tcg cac ctt agt caa cat aaa aga ata     1795
 Gly Lys Ala Phe Arg Tyr Ser Ser His Leu Ser Gln His Lys Arg Ile
                 475                 480                 485

 cat aca ggg gag agg cca tat aaa tgt caa aag tgt ggg caa gcc ttc     1843
 His Thr Gly Glu Arg Pro Tyr Lys Cys Gln Lys Cys Gly Gln Ala Phe
             490                 495                 500

 agt atc tca tca ggc ctt aca gta cac atg aga act cac act ggt gaa     1891
 Ser Ile Ser Ser Gly Leu Thr Val His Met Arg Thr His Thr Gly Glu
         505                 510                 515

 cgg ccc ttt gaa tgt cag gaa tgt ggg aaa gcc ttt act cgg tcc aca     1939
 Arg Pro Phe Glu Cys Gln Glu Cys Gly Lys Ala Phe Thr Arg Ser Thr
     520                 525                 530

 tat ctt att cga cat cta aga agt cat agt gtg gag aaa cca tat aag     1987
 Tyr Leu Ile Arg His Leu Arg Ser His Ser Val Glu Lys Pro Tyr Lys
 535                 540                 545                 550

 gaa tgt ggg caa acc ttt agt aat tcc tca tgc ctt act gaa tgt gtg     2035
 Glu Cys Gly Gln Thr Phe Ser Asn Ser Ser Cys Leu Thr Glu Cys Val
                 555                 560                 565

 tga attg gggctgatac ttggaaagaa tgtggtaaag ccactacttc ctcacactta     2092
 






      <210> 107
      <211> 488
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (106)..(321)

      <400> 107
 cccacccttt atagttgagg aactcaagct tcctcccctt gcagcctgcg ttcccctgat     60

 aacagctctc ccttgcagac accttccttg cccttgccac ccaca    atg cac acc     114
                                                      Met His Thr
                                                        1

 ttc ctg tca ttg act cac tct tgc tct tcc atc cgt gca ttg gag tcg      162
 Phe Leu Ser Leu Thr His Ser Cys Ser Ser Ile Arg Ala Leu Glu Ser
       5                  10                  15

 cct ctc cct gcg ggc agt tgc tgc acc ccg agt gcc tgg cac acc tgt      210
 Pro Leu Pro Ala Gly Ser Cys Cys Thr Pro Ser Ala Trp His Thr Cys
  20                  25                  30                  35

 ggc cct gag gag gtg ctc aaa cac gtg att cct ggg ggc ctc aga tct      258
 Gly Pro Glu Glu Val Leu Lys His Val Ile Pro Gly Gly Leu Arg Ser
                  40                  45                  50

 ggg tgg ctc ctt tgt gtg aca cat ggt ggg aag cag agc tca gtg ggt      306
 Gly Trp Leu Leu Cys Val Thr His Gly Gly Lys Gln Ser Ser Val Gly
              55                  60                  65

 cat gtg cca ccc tag gggatgaggg ctgtcattgt cctctcctga gccagccttg      361
 His Val Pro Pro 
          70

 gccacacttc caggggaccc tcccccgatg cctggcctgg ccagcggcca catgctctga    421

 agctgaccct ttgctgtgag gtcctgcaag gcagggcgtg tgtgtgagtt gcccaccact    481

 ggggcct                                                              488




      <210> 108
      <211> 2171
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (1622)..(1873)

      <400> 108
 atctttccat gtggccttga tcaggtcata actatgcatg aacatttttt atcaggaatg     60

 gccgatgtgt atgtgatttg taatcacaag taatgattca tcaggaaatg tcaatcctgt    120

 tggaaagatt gcacctttac ttgcagaagt gacccccacc tgtgtcctga cctctccatt    180

 tacaggctct ctcacccatt tcccccacct cctttaattt ttgctttact gtcataaagt    240

 aggactaaga ttggtctaag cattgcatgt tcttttgtga tggtaaatcc aaaggaaggc    300

 ctataagtat taacatttga aataactgct aattcaggaa aatggaagaa aaaaaaatta    360

 tttgaaacac agaacccatt tcatggcctg cctgatatct gtgaaatcag ggctggagct    420

 ttacttagga ttcacatggc ctcctaggaa ccatgggaca aatgggaaac aggttatcgg    480

 gggattcatg aagtcagtga gagtaattgc ttcttttttg cgggtgaact gaatgtattt    540

 cttcaccaaa tcttgatgtt aacaattaaa aagaagaaat gacatgcaag taggtcttag    600

 cagaaaaatg caggctgggc atgagtcatg ttgttaccct cccacatgct cctacaatcc    660

 acagagatgc ctgtctgcag gttcttgaag ttattgttag tatttggtat ctcaaatttt    720

 tcgtcactgt tcacatgcca ctttctctgt gcacagtggt atcctcattt gctttttaac    780

 ctacactgag gagtctttgt caggttgcac tgattttcca attctgcagt aatgagtaag    840

 ctcacggcat ggggaagaag acagtcagtc caatgaagtt ctctaaatta ttttaacatt    900

 gcctttgaag gccttgactc atccttagct atttcaatga agaaattcct accatgaatt    960

 taaaacccta aaaattctgt ttcaaattct ttgggcattg gggtactcag atatcccatt   1020

 gtggaagaat tttaagaata aatagaagtt tctgttgaga accatgagca acatgtttct   1080

 tacaatgaga attgctatgc attttaaaat tgcaaatata tatgaaaatt gaagacaaga   1140

 ggaaattgta tttctaactt gattctgatc actcacagag gtggcatatt attatagttg   1200

 ggacatcctt tgcacccttc ataaaaaagg ccagctgact gctcagcatc acctgccaag   1260

 gccactagat ttgtgtttac aggggtatct ctgtgatgct tgtcacatca ctcttgacca   1320

 cctctgttaa taaattccga cagtgcagtg gcgatcggag tgtgaactta tgttcccagc   1380

 atatggaaag ctatcttagg ttttaaggta gtagaaattg cccaggagtt tgacagcaac   1440

 tttgtttccc gggtctaaaa tcgtatccca ctgaggtgta tgcagtggag cataatacat   1500

 gcaaatacat gcaaaactcc ttttgtttca cctaagattc actttctatc ttactttccc   1560

 ttcctgccta gtgtgacttt tgcccccaag agtgcctgga cagcattcta gtttctacaa   1620

 a    atg gtc ctc tgt gta ggt gaa tgt gtc cca aac ctg cta tca ctt    1666
      Met Val Leu Cys Val Gly Glu Cys Val Pro Asn Leu Leu Ser Leu
        1               5                  10                  15

 tct tgt ttc agt gtg act gtc ttg tta gag gtg aag ttt atc cag ggt     1714
 Ser Cys Phe Ser Val Thr Val Leu Leu Glu Val Lys Phe Ile Gln Gly
                  20                  25                  30

 aac ttg ctc act aac tat tcc ttt tta tgg cct ggg gtt aaa ggg agc     1762
 Asn Leu Leu Thr Asn Tyr Ser Phe Leu Trp Pro Gly Val Lys Gly Ser
              35                  40                  45

 atg gct cac act ggt gaa aat aag gaa ggc ctg gtc tta tct tgt att     1810
 Met Ala His Thr Gly Glu Asn Lys Glu Gly Leu Val Leu Ser Cys Ile
          50                  55                  60

 aat aat act ggc tgc att cca cca gcc aga gat ttc tat ctg cga aga     1858
 Asn Asn Thr Gly Cys Ile Pro Pro Ala Arg Asp Phe Tyr Leu Arg Arg
      65                  70                  75

 cct atg aaa cac tga agagaaatgt aggcagaagg aaatggccac atatcacaag     1913
 Pro Met Lys His 
  80

 ttctattata tattcttttg taaatacata ttgtatatta cttggatgtt ttcttatatc   1973

 atttactgtc tttttgagtt aatgtcagtt tttactctct caacttacta tgtaacattg   2033

 taaataacat aatgtccttt attatttata tttaagcatc taacatatag agttgttttc   2093

 atataagttt aagataaatg tcaaaaatat atgttctttt gtttttcttt gctttaaaaa   2153

 aaaaaaaaaa aaagatat                                                 2171




      <210> 109
      <211> 954
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (1)..(954)

      <400> 109
  atg ggg cca tcc aac cag gca gtc cgc ctg cac agc agc tgt ccc tgc      48
  Met Gly Pro Ser Asn Gln Ala Val Arg Leu His Ser Ser Cys Pro Cys
    1               5                  10                  15

 tca tcg ggc tgg agg aca gaa gac aga acc cta aaa cca cag gtt gct       96
 Ser Ser Gly Trp Arg Thr Glu Asp Arg Thr Leu Lys Pro Gln Val Ala
              20                  25                  30

 gaa aag cca gga gtc aaa atg act gag cgc ttt gac tgc cac cat tgc      144
 Glu Lys Pro Gly Val Lys Met Thr Glu Arg Phe Asp Cys His His Cys
          35                  40                  45

 aac gaa tct ctc ttt ggc aag aag tac atc ctg cgg gag gag agc ccc      192
 Asn Glu Ser Leu Phe Gly Lys Lys Tyr Ile Leu Arg Glu Glu Ser Pro
      50                  55                  60

 tac tgc gtg gtg tgc ttt gag acc ctg ttc gcc aac acc tgc gag gag      240
 Tyr Cys Val Val Cys Phe Glu Thr Leu Phe Ala Asn Thr Cys Glu Glu
  65                  70                  75                  80

 tgt ggg aag ccc atc ggc tgt gac tgc aag gac ttg tct tac aag gac      288
 Cys Gly Lys Pro Ile Gly Cys Asp Cys Lys Asp Leu Ser Tyr Lys Asp
                  85                  90                  95

 cgg cac tgg cat gaa gcc tgt ttc cac tgc tcg cag tgc aga aac tca      336
 Arg His Trp His Glu Ala Cys Phe His Cys Ser Gln Cys Arg Asn Ser
             100                 105                 110

 ctg gtg gac aag ccc ttt gct gcc aag gag gac cag ctg ctc tgt aca      384
 Leu Val Asp Lys Pro Phe Ala Ala Lys Glu Asp Gln Leu Leu Cys Thr
         115                 120                 125

 gac tgc tat tcc aac gag tac tca tcc aag tgc cag gaa tgc aag aag      432
 Asp Cys Tyr Ser Asn Glu Tyr Ser Ser Lys Cys Gln Glu Cys Lys Lys
     130                 135                 140

 acc atc atg cca ggt acc cgc aag atg gag tac aag ggc agc agc tgg      480
 Thr Ile Met Pro Gly Thr Arg Lys Met Glu Tyr Lys Gly Ser Ser Trp
 145                 150                 155                 160

 cat gag acc tgc ttc atc tgc cac cgc tgc cag cag cca att gga acc      528
 His Glu Thr Cys Phe Ile Cys His Arg Cys Gln Gln Pro Ile Gly Thr
                 165                 170                 175

 aag agt ttc atc ccc aaa gac aat cag aat ttc tgt gtg ccc tgc tat      576
 Lys Ser Phe Ile Pro Lys Asp Asn Gln Asn Phe Cys Val Pro Cys Tyr
             180                 185                 190

 gag aaa caa cat gcc atg cag tgc gtt cag tgc aaa atg ccc atc acc      624
 Glu Lys Gln His Ala Met Gln Cys Val Gln Cys Lys Met Pro Ile Thr
         195                 200                 205

 acg gga ggg gtc act tac cgg gag cag ccc tgg cac aag gag tgc ttc      672
 Thr Gly Gly Val Thr Tyr Arg Glu Gln Pro Trp His Lys Glu Cys Phe
     210                 215                 220

 gtg tgc acc gcc tgc agg aag cag ctg tct ggg cag cgc ttc aca gct      720
 Val Cys Thr Ala Cys Arg Lys Gln Leu Ser Gly Gln Arg Phe Thr Ala
 225                 230                 235                 240

 cgc gat gac ttt gcc tac tgc ctg aac tgc ttc tgt gac ttg tat gcc      768
 Arg Asp Asp Phe Ala Tyr Cys Leu Asn Cys Phe Cys Asp Leu Tyr Ala
                 245                 250                 255

 aag aag tgt gct ggg tgc acc aac ccc atc agc gga ctt ggt ggc aca      816
 Lys Lys Cys Ala Gly Cys Thr Asn Pro Ile Ser Gly Leu Gly Gly Thr
             260                 265                 270

 aaa tac atc tcc ttt gag gaa cgg cag tgg cat aac gac tgc ttt aac      864
 Lys Tyr Ile Ser Phe Glu Glu Arg Gln Trp His Asn Asp Cys Phe Asn
         275                 280                 285

 tgt aag aag tgc tcc ctc tca ctg gtg ggg cgt ggc ttc ctc aca gag      912
 Cys Lys Lys Cys Ser Leu Ser Leu Val Gly Arg Gly Phe Leu Thr Glu
     290                 295                 300

 agg gac gac atc ctg tgc ccc gac tgt ggg aaa gac atc tga              954
 Arg Asp Asp Ile Leu Cys Pro Asp Cys Gly Lys Asp Ile 
 305                 310                 315





      <210> 110
      <211> 709
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (159)..(659)

      <400> 110
 aagccagctg atatggtagc aaccaaagat tccagtgttt gagcatatga aagactctgc     60

 ctgcttaatt gtgctagcaa taacagcatc taaagtgaag acttaagaaa aacttagtga    120

 ctactagatt atccttagga ctctgcatta actctata    atg ttc ttg gta tta     173
                                              Met Phe Leu Val Leu
                                                1               5

 aaa aaa aag cat att tgt cac aga aat tta gtt aac atc tta caa ctg      221
 Lys Lys Lys His Ile Cys His Arg Asn Leu Val Asn Ile Leu Gln Leu
                  10                  15                  20

 aac atg tat gta tgt tgc tta gat aaa tgt aat cac tgt aaa cat cta      269
 Asn Met Tyr Val Cys Cys Leu Asp Lys Cys Asn His Cys Lys His Leu
              25                  30                  35

 tat gat ctg gga ttt tgt ttt tat ttt gaa atg gga gct ttt ttg ttt      317
 Tyr Asp Leu Gly Phe Cys Phe Tyr Phe Glu Met Gly Ala Phe Leu Phe
          40                  45                  50

 aca agt tca tta aaa act aaa aac tgt ttc tgt aag gaa atg aga ttt      365
 Thr Ser Ser Leu Lys Thr Lys Asn Cys Phe Cys Lys Glu Met Arg Phe
      55                  60                  65

 ttt tta aac aac aaa aaa tgc ctt gct gac tca cta tta aat aaa aat      413
 Phe Leu Asn Asn Lys Lys Cys Leu Ala Asp Ser Leu Leu Asn Lys Asn
  70                  75                  80                  85

 ctc ccc aat ttt ttg ata gac tac ttc aag cca ttt gtt aca tgg tat      461
 Leu Pro Asn Phe Leu Ile Asp Tyr Phe Lys Pro Phe Val Thr Trp Tyr
                  90                  95                 100

 tcc ttt gca agt caa ttt agg ttt cgt gtt ata act ttt cct ctt ttt      509
 Ser Phe Ala Ser Gln Phe Arg Phe Arg Val Ile Thr Phe Pro Leu Phe
             105                 110                 115

 tta aga aaa atg aaa aaa gta att ctt ttg tct gaa ggg gaa agg cat      557
 Leu Arg Lys Met Lys Lys Val Ile Leu Leu Ser Glu Gly Glu Arg His
         120                 125                 130

 tct ttc att ttt ttc ttt ttt ttt ttt ttt ttt tat gac ttg cag gca      605
 Ser Phe Ile Phe Phe Phe Phe Phe Phe Phe Phe Tyr Asp Leu Gln Ala
     135                 140                 145

 caa tat cta gta ctg caa ctg cca gaa ctt ggt att gta gct gct gcc      653
 Gln Tyr Leu Val Leu Gln Leu Pro Glu Leu Gly Ile Val Ala Ala Ala
 150                 155                 160                 165

 cgc tga ctagcagctg gactgatttt gaataaaaat gaaagcatta aagggtttcc       709
 Arg 






      <210> 111
      <211> 683
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (150)..(683)

      <400> 111
 gaattcccgg ttcgacgatt tcgtggcgcg gtgagtcaga gccgcacagt aaatatttgt     60

 attagccgga gccggctcgc taatggtgga cgcgtgaggc ggaggcgcgg gcggcggagg    120

 gaggccggag cgggcagcgc ggcggcgcc  atg tcc gtg aac atg gac gag ctc     173
                                  Met Ser Val Asn Met Asp Glu Leu
                                    1               5

 aag cac cag gtc atg atc aac cag ttc gtg ctg acg gcg ggc tgc gcg      221
 Lys His Gln Val Met Ile Asn Gln Phe Val Leu Thr Ala Gly Cys Ala
      10                  15                  20

 gcc gac cag gcg aag caa ctg ctg cag gcg gcc cac tgg cag ttc gag      269
 Ala Asp Gln Ala Lys Gln Leu Leu Gln Ala Ala His Trp Gln Phe Glu
  25                  30                  35                  40

 aca gcc ctc agc gcc ttt ttc cag gag acc aac atc ccc tac agc cac      317
 Thr Ala Leu Ser Ala Phe Phe Gln Glu Thr Asn Ile Pro Tyr Ser His
                  45                  50                  55

 cat cac cac cag atg atg tgc acc ccc gcc aat acc cct gct aca ccc      365
 His His His Gln Met Met Cys Thr Pro Ala Asn Thr Pro Ala Thr Pro
              60                  65                  70

 ccc aac ttc cct gac gct ctc acc atg ttc tcc cgt ctc aag gcc tcc      413
 Pro Asn Phe Pro Asp Ala Leu Thr Met Phe Ser Arg Leu Lys Ala Ser
          75                  80                  85

 gag agc ttc cac agc ggt ggc agc ggc agc ccg atg gcc gcg aca gcc      461
 Glu Ser Phe His Ser Gly Gly Ser Gly Ser Pro Met Ala Ala Thr Ala
      90                  95                 100

 acg tca ccc ccg cca cac ttc ccc cat gcc gcc acc agc agc tct gcg      509
 Thr Ser Pro Pro Pro His Phe Pro His Ala Ala Thr Ser Ser Ser Ala
 105                 110                 115                 120

 gcc tcc agc tgg ccc acg gcg gcc tcg ccc ccg ggg ggc cca cag cac      557
 Ala Ser Ser Trp Pro Thr Ala Ala Ser Pro Pro Gly Gly Pro Gln His
                 125                 130                 135

 cac cag cca cag ccg ccc ctg tgg act cca aca ccc cct tct ccg gct      605
 His Gln Pro Gln Pro Pro Leu Trp Thr Pro Thr Pro Pro Ser Pro Ala
             140                 145                 150

 tca gac tgg cca ccc ctg gcc ccc caa cag gcc acc tca gaa ccc agg      653
 Ser Asp Trp Pro Pro Leu Ala Pro Gln Gln Ala Thr Ser Glu Pro Arg
         155                 160                 165

 gcc cac cct gcc atg gag gca gag aga taa                              683
 Ala His Pro Ala Met Glu Ala Glu Arg 
     170                 175





      <210> 112
      <211> 847
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (153)..(530)

      <400> 112
 gagtggcgta gacgagttaa gtcctggtct gcgtggaggt cgacgactcc gtcgcagact     60

 acggacctgt ctgggtctca gccgccaaag accccgtccg gtaggtgagt ggctcacttt    120

 gagggcaagc cttctcggat cgaggcttct tc  atg gcc gct cag atc gtg agc     173
                                      Met Ala Ala Gln Ile Val Ser
                                        1               5

 ggc cgg ggc tgc tct ctt tgc gga gga tgg cgt cta atg agc gca gtt      221
 Gly Arg Gly Cys Ser Leu Cys Gly Gly Trp Arg Leu Met Ser Ala Val
          10                  15                  20

 gat tcg agg tgg gcg ctg ggg cac gtc tcc ctt ttg gca tac tgt ttg      269
 Asp Ser Arg Trp Ala Leu Gly His Val Ser Leu Leu Ala Tyr Cys Leu
      25                  30                  35

 agg ggt act gag gtg aaa ggg cgg tca ctg ttc ggg tcg ttt tta cac      317
 Arg Gly Thr Glu Val Lys Gly Arg Ser Leu Phe Gly Ser Phe Leu His
  40                  45                  50                  55

 agc ggt tgt gcg ccc gtc cct gcc agt ctt aat gtc ttc atc tcc tgg      365
 Ser Gly Cys Ala Pro Val Pro Ala Ser Leu Asn Val Phe Ile Ser Trp
                  60                  65                  70

 aca cgt aga ata gtg ggc cgg gat ctc cct gac ttt gtc cat ctc ctc      413
 Thr Arg Arg Ile Val Gly Arg Asp Leu Pro Asp Phe Val His Leu Leu
              75                  80                  85

 cct ccc cgc atc tct tcc ttg ctg aag aaa cta agt cat ttg tcc tat      461
 Pro Pro Arg Ile Ser Ser Leu Leu Lys Lys Leu Ser His Leu Ser Tyr
          90                  95                 100

 aga gtt tcc cac aac ctg gat ttt gga gat tac atg gtg ctg ttt tta      509
 Arg Val Ser His Asn Leu Asp Phe Gly Asp Tyr Met Val Leu Phe Leu
     105                 110                 115

 aat gtt tct ctg tcc cta taa at tggcagcctg tctgtaggct tgatcagatt      562
 Asn Val Ser Leu Ser Leu 
 120                 125

 cagggtcaag tttttggcaa gaatacttca tagtgtatgt gctcccacca ggaggcaggt    622

 aacatctgtc catcattctt tctttactga aatactttat caagagaaac ttccctttat    682

 caactgtttg gttatcctaa tgtctataat ttgaaaaaac tgtttatagt gctcacttca    742

 acagcataca tgtaaatggg actggtgcag agatgagcac ggccctatgc aaggatgaca    802

 cccaaattca tgaagccttc catgtttttg tatcctaaga aaaat                    847




      <210> 113
      <211> 1686
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (370)..(1686)

      <400> 113
 atggctgagc tggtaatcaa gcttcaagac aaagcctctt ttactcttcc ctctcttttc     60

 ctcaagcaga agtctctcca catggctgcc acagcttgga ttgcactgca ctgggtctca    120

 caccccaggg gctgcagcaa gtactacttg gttactgctg atgtttattc atggccaaag    180

 aaagaaagat tttctcctgg agctgtgaac tacactgcct gtgcctgggg taaggatgat    240

 gcaggcactt tcttggccat cccagttggc atctcacaga gcaccaggat ttgcccagaa    300

 attgcagtcc cagtggctta cactgccttt caggtttatt tagaacccca gagcgcttta    360

 gcctatgcc    atg ttg ttt gaa tta agt gcc aca tgt gag gct aag gga     408
              Met Leu Phe Glu Leu Ser Ala Thr Cys Glu Ala Lys Gly
                1               5                  10

 gtg ttg aca ttc agg gat gtg gct gta gaa ttc tcc cca gaa gag tgg      456
 Val Leu Thr Phe Arg Asp Val Ala Val Glu Phe Ser Pro Glu Glu Trp
      15                  20                  25

 gaa tgc ctg gac tct gct cag cag cgt ttg tat agg gat gtg atg tta      504
 Glu Cys Leu Asp Ser Ala Gln Gln Arg Leu Tyr Arg Asp Val Met Leu
  30                  35                  40                  45

 gag aac tat gga aac ctg gtc tcc ttg ggt ctt gct atc ttt aag cca      552
 Glu Asn Tyr Gly Asn Leu Val Ser Leu Gly Leu Ala Ile Phe Lys Pro
                  50                  55                  60

 gac ttg atg acc tgt ctg gag caa aga aaa gag cct tgg aaa gtg aag      600
 Asp Leu Met Thr Cys Leu Glu Gln Arg Lys Glu Pro Trp Lys Val Lys
              65                  70                  75

 aga cag gag gca gta gcc aaa cac cca gct ggt tct ttt cat ttt act      648
 Arg Gln Glu Ala Val Ala Lys His Pro Ala Gly Ser Phe His Phe Thr
          80                  85                  90

 gca gag ata ttg ccg gat cat gac ata aaa gat tca ttt caa aaa gtg      696
 Ala Glu Ile Leu Pro Asp His Asp Ile Lys Asp Ser Phe Gln Lys Val
      95                 100                 105

 att ctg aga aaa tat gga agc tgt gac ctt aat aat tta cat tta aag      744
 Ile Leu Arg Lys Tyr Gly Ser Cys Asp Leu Asn Asn Leu His Leu Lys
 110                 115                 120                 125

 aaa gac tac caa agt gtg ggt aat tgc aag ggg cag aaa agc agt tat      792
 Lys Asp Tyr Gln Ser Val Gly Asn Cys Lys Gly Gln Lys Ser Ser Tyr
                 130                 135                 140

 aat ggc ctt cat caa tgt ttg tca gct acc cat agc aaa acc tgt caa      840
 Asn Gly Leu His Gln Cys Leu Ser Ala Thr His Ser Lys Thr Cys Gln
             145                 150                 155

 tgt aat aaa tgt ggc aga ggt ttt cag ttg tgc tca atc ttc act gaa      888
 Cys Asn Lys Cys Gly Arg Gly Phe Gln Leu Cys Ser Ile Phe Thr Glu
         160                 165                 170

 cat aaa gac att ttt agc aga gag aaa tgc cac aaa tgt gaa gaa tgt      936
 His Lys Asp Ile Phe Ser Arg Glu Lys Cys His Lys Cys Glu Glu Cys
     175                 180                 185

 ggc aaa gac tgt agg ttg ttc tca gat ttt act aga cat aag aaa att      984
 Gly Lys Asp Cys Arg Leu Phe Ser Asp Phe Thr Arg His Lys Lys Ile
 190                 195                 200                 205

 cat act gta gag aga tgc tac aaa tgt gaa gaa tgt ggc aaa gcg ttt     1032
 His Thr Val Glu Arg Cys Tyr Lys Cys Glu Glu Cys Gly Lys Ala Phe
                 210                 215                 220

 aaa aag ttt tca aac ctt act gaa cat aag aga gtt cat act gga gag     1080
 Lys Lys Phe Ser Asn Leu Thr Glu His Lys Arg Val His Thr Gly Glu
             225                 230                 235

 aaa cct tac aaa tgt gaa gga tgt ggc aaa act ttt acc tgc tcc tca     1128
 Lys Pro Tyr Lys Cys Glu Gly Cys Gly Lys Thr Phe Thr Cys Ser Ser
         240                 245                 250

 acc ctt gtt aaa cac aag aga aat cat act gga gac aga ccc tac aaa     1176
 Thr Leu Val Lys His Lys Arg Asn His Thr Gly Asp Arg Pro Tyr Lys
     255                 260                 265

 tgt gaa gaa tgt ggc aaa gcc ttt aag tgc ttc tca gac ctt act aat     1224
 Cys Glu Glu Cys Gly Lys Ala Phe Lys Cys Phe Ser Asp Leu Thr Asn
 270                 275                 280                 285

 cat aag aga att cat act gga gag aaa ccc tac aaa tgt gaa gaa tgt     1272
 His Lys Arg Ile His Thr Gly Glu Lys Pro Tyr Lys Cys Glu Glu Cys
                 290                 295                 300

 aac aaa gcc tat agg tgg ttc tca gac ctt gct aaa cat aag ata att     1320
 Asn Lys Ala Tyr Arg Trp Phe Ser Asp Leu Ala Lys His Lys Ile Ile
             305                 310                 315

 cat act gga gac aaa ccc tac aca tgt aat gaa tgt gga aaa gct ttt     1368
 His Thr Gly Asp Lys Pro Tyr Thr Cys Asn Glu Cys Gly Lys Ala Phe
         320                 325                 330

 aag tgg ttc tca gcc ctt agt aaa cat aag aga att cat act gga gag     1416
 Lys Trp Phe Ser Ala Leu Ser Lys His Lys Arg Ile His Thr Gly Glu
     335                 340                 345

 aaa ccc tac atc tgt gaa gaa tgt ggc aaa gcc ttt acc cgc tcc tca     1464
 Lys Pro Tyr Ile Cys Glu Glu Cys Gly Lys Ala Phe Thr Arg Ser Ser
 350                 355                 360                 365

 acc ctt ttt aac cac aag aga att cat atg gaa gag aga cct tac aaa     1512
 Thr Leu Phe Asn His Lys Arg Ile His Met Glu Glu Arg Pro Tyr Lys
                 370                 375                 380

 tgt gaa gaa tgc agc aaa acc ttt aag tgc ttc tca gac ctg act aat     1560
 Cys Glu Glu Cys Ser Lys Thr Phe Lys Cys Phe Ser Asp Leu Thr Asn
             385                 390                 395

 cat aag aga att cac act gga gag aaa ccc tac aaa tgt gaa gaa tgt     1608
 His Lys Arg Ile His Thr Gly Glu Lys Pro Tyr Lys Cys Glu Glu Cys
         400                 405                 410

 ggc aaa gca tcg agc tgg ttc tca cac ctc atc aga cat aag aga att     1656
 Gly Lys Ala Ser Ser Trp Phe Ser His Leu Ile Arg His Lys Arg Ile
     415                 420                 425

 cat act aga gag aag ctc cac aag tgt taa                             1686
 His Thr Arg Glu Lys Leu His Lys Cys 
 430                 435





      <210> 114
      <211> 2430
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (149)..(1732)

      <400> 114
 tcgccttctg cttgccacag tcatagtggg cagtcagtga atcttcccca agtgctgaca     60

 attaatacct ggtttagcgg caaagattca gagaggcgtg agcagcccct ctggccttca    120

 gacaaaaatc tacgtaccat cagaaact   atg tct ctg cag atg gta aca gtc     172
                                  Met Ser Leu Gln Met Val Thr Val
                                    1               5

 agt aat aac ata gcc tta att cag cca ggc ttc tca ctg atg aat ttt      220
 Ser Asn Asn Ile Ala Leu Ile Gln Pro Gly Phe Ser Leu Met Asn Phe
      10                  15                  20

 gat gga caa gtt ttc ttc ttt gga caa aaa ggc tgg ccc aaa aga tcc      268
 Asp Gly Gln Val Phe Phe Phe Gly Gln Lys Gly Trp Pro Lys Arg Ser
  25                  30                  35                  40

 tgc ccc act gga gtt ttc cat ctg gat gta aag cat aac cat gtc aaa      316
 Cys Pro Thr Gly Val Phe His Leu Asp Val Lys His Asn His Val Lys
                  45                  50                  55

 ctg aag cct aca att ttc tct aag gat tcc tgc tac ctc cct cct ctt      364
 Leu Lys Pro Thr Ile Phe Ser Lys Asp Ser Cys Tyr Leu Pro Pro Leu
              60                  65                  70

 cgc tac cca gcc act tgc aca ttc aaa ggc agc ttg gag tct gaa aag      412
 Arg Tyr Pro Ala Thr Cys Thr Phe Lys Gly Ser Leu Glu Ser Glu Lys
          75                  80                  85

 cat caa tac atc atc cat gga ggg aaa aca cca aac aat gag gtt tca      460
 His Gln Tyr Ile Ile His Gly Gly Lys Thr Pro Asn Asn Glu Val Ser
      90                  95                 100

 gat aag att tat gtc atg tct att gtt tgc aag aac aac aaa aag gtt      508
 Asp Lys Ile Tyr Val Met Ser Ile Val Cys Lys Asn Asn Lys Lys Val
 105                 110                 115                 120

 act ttt cgc tgc aca gag aaa gac ttg gta gga gat gtt cct gaa gcc      556
 Thr Phe Arg Cys Thr Glu Lys Asp Leu Val Gly Asp Val Pro Glu Ala
                 125                 130                 135

 aga tat ggt cat tcc att aat gtg gtg tac agc cga ggg aaa agt atg      604
 Arg Tyr Gly His Ser Ile Asn Val Val Tyr Ser Arg Gly Lys Ser Met
             140                 145                 150

 ggt gtt ctc ttt gga gga cgc tca tac atg cct tct acc cac aga acc      652
 Gly Val Leu Phe Gly Gly Arg Ser Tyr Met Pro Ser Thr His Arg Thr
         155                 160                 165

 aca gaa aaa tgg aat agt gta gct gac tgc ctg ccc tgt gtt ttc ctg      700
 Thr Glu Lys Trp Asn Ser Val Ala Asp Cys Leu Pro Cys Val Phe Leu
     170                 175                 180

 gtg gat ttt gaa ttt ggg tgt gct aca tca tac att ctt cca gaa ctt      748
 Val Asp Phe Glu Phe Gly Cys Ala Thr Ser Tyr Ile Leu Pro Glu Leu
 185                 190                 195                 200

 cag gat ggg cta tct ttt cat gtc tct att gcc aaa aat gac acc atc      796
 Gln Asp Gly Leu Ser Phe His Val Ser Ile Ala Lys Asn Asp Thr Ile
                 205                 210                 215

 tat att tta gga gga cat tca ctt gcc aat aat atc cgg cct gcc aac      844
 Tyr Ile Leu Gly Gly His Ser Leu Ala Asn Asn Ile Arg Pro Ala Asn
             220                 225                 230

 ctg tac aga ata agg gtt gat ctt ccc ctg ggt agc cca gct gtg aat      892
 Leu Tyr Arg Ile Arg Val Asp Leu Pro Leu Gly Ser Pro Ala Val Asn
         235                 240                 245

 tgc aca gtc ttg cca gga gga atc tct gtc tcc agt gca atc ctg act      940
 Cys Thr Val Leu Pro Gly Gly Ile Ser Val Ser Ser Ala Ile Leu Thr
     250                 255                 260

 caa act aac aat gat gaa ttt gtt att gtt ggt ggc tat cag ctt gaa      988
 Gln Thr Asn Asn Asp Glu Phe Val Ile Val Gly Gly Tyr Gln Leu Glu
 265                 270                 275                 280

 aat caa aaa aga atg atc tgc aac atc atc tct tta gag gac aac aag     1036
 Asn Gln Lys Arg Met Ile Cys Asn Ile Ile Ser Leu Glu Asp Asn Lys
                 285                 290                 295

 ata gaa att cgt gag atg gag acc cca gat tgg acc cca gac att aag     1084
 Ile Glu Ile Arg Glu Met Glu Thr Pro Asp Trp Thr Pro Asp Ile Lys
             300                 305                 310

 cac agc aag ata tgg ttt gga agc aac atg gga aat gga act gtt ttt     1132
 His Ser Lys Ile Trp Phe Gly Ser Asn Met Gly Asn Gly Thr Val Phe
         315                 320                 325

 ctt ggc ata cca gga gac aat aaa caa gtt gtt tca gaa gga ttc tat     1180
 Leu Gly Ile Pro Gly Asp Asn Lys Gln Val Val Ser Glu Gly Phe Tyr
     330                 335                 340

 ttc tat atg ttg aaa tgt gct gaa gat gat act aat gaa gag cag aca     1228
 Phe Tyr Met Leu Lys Cys Ala Glu Asp Asp Thr Asn Glu Glu Gln Thr
 345                 350                 355                 360

 aca ttc aca aac agt caa aca tca aca gaa gat cca ggg gat tcc act     1276
 Thr Phe Thr Asn Ser Gln Thr Ser Thr Glu Asp Pro Gly Asp Ser Thr
                 365                 370                 375

 ccc ttt gaa gac tct gaa gaa ttt tgt ttc agt gca gaa gca aat agt     1324
 Pro Phe Glu Asp Ser Glu Glu Phe Cys Phe Ser Ala Glu Ala Asn Ser
             380                 385                 390

 ttt gat ggt gat gat gaa ttt gac acc tat aat gaa gat gat gaa gaa     1372
 Phe Asp Gly Asp Asp Glu Phe Asp Thr Tyr Asn Glu Asp Asp Glu Glu
         395                 400                 405

 gat gag tct gag aca ggc tac tgg att aca tgc tgc cct act tgt gat     1420
 Asp Glu Ser Glu Thr Gly Tyr Trp Ile Thr Cys Cys Pro Thr Cys Asp
     410                 415                 420

 gtg gat atc aac act tgg gta cca ttc tat tca act gag ctc aac aaa     1468
 Val Asp Ile Asn Thr Trp Val Pro Phe Tyr Ser Thr Glu Leu Asn Lys
 425                 430                 435                 440

 ccc gcc atg atc tac tgc tct cat ggg gat ggg cac tgg gtc cat gct     1516
 Pro Ala Met Ile Tyr Cys Ser His Gly Asp Gly His Trp Val His Ala
                 445                 450                 455

 cag tgc atg gat ctg gca gaa cgc aca ctc atc cat ctg tca gca gga     1564
 Gln Cys Met Asp Leu Ala Glu Arg Thr Leu Ile His Leu Ser Ala Gly
             460                 465                 470

 agc aac aag tat tac tgc aat gag cat gtg gag ata gca aga gct cta     1612
 Ser Asn Lys Tyr Tyr Cys Asn Glu His Val Glu Ile Ala Arg Ala Leu
         475                 480                 485

 cac act ccc caa aga gtc cta ccc tta aaa aag cct cca atg aaa tcc     1660
 His Thr Pro Gln Arg Val Leu Pro Leu Lys Lys Pro Pro Met Lys Ser
     490                 495                 500

 ctc cgt aaa aaa ggt tct gga aaa atc ttg act cct gcc aag aaa tcc     1708
 Leu Arg Lys Lys Gly Ser Gly Lys Ile Leu Thr Pro Ala Lys Lys Ser
 505                 510                 515                 520

 ttt ctt aga agg ttg ttt gat tag ttttgcaaaa gcctttcaga ttcaggtgta    1762
 Phe Leu Arg Arg Leu Phe Asp 
                 525

 tggaattttt gaatctattt ttaaaatcat aacattgatt ttaaaaatac atttttgttt   1822

 atttaaaatg cctatgtttt cttttagtta catgaattaa gggccagaaa aaagtgttta   1882

 taatgcaatg ataaataaag tcattctaga ccctatacat tttgaaaata ttttacccaa   1942

 atactcaatt tactaattta ttcttcactg aggatttctg atctgatttt ttattcaaca   2002

 aaccttaaac acccagaagc agtaataacc atcgaggtat gtttatattt attatatgag   2062

 tcttggtaac aaataaccta taaagtgttt atgacaaatt tagccaataa agaaattaac   2122

 acccaaaaga attaaattga ttattttgtg caacataaca attcggcagt tggccaaaac   2182

 ttaaaagcaa gatctactac atcccacatt agtgttcttt atataccttc aagcaaccct   2242

 ttggattatg cccatgaaca agttagtttc tcatagcttt acagatgtag atataaatat   2302

 aaatatatgt atacatatag atacgatatg ttctccactg acacaaaaga agaaataaat   2362

 aatctacatc aagtttgaca tgttttcctg aattactgtg atgcattttc tttaaggatt   2422

 tcccctcg                                                            2430




      <210> 115
      <211> 1586
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (606)..(1586)

      <400> 115
 cgttgctagc gcttgtccgg tggctgctgc gctgccgcaa cgaatagggt ttctggctgc     60

 gtaagaggga cgggggcgcg gagctctggg aaactgcgcc aggcgcccga aaggtgaaca    120

 cgggagtcgc gcgtctcccc cgcagcagcg gtaaagcgga agttatgctg cagccggagc    180

 ccgggcttcc tcccggagcc gcgtcccggg gcccggctgc cccgagctga gcggagcatc    240

 ctttccgggt gaggggagga gaggacttgg cgcgttcccc tcgctgcccc gggagccgca    300

 gccgcggtgt tcatgccgcg gagcagccag gctcctccga cgaaaacctg catttatttg    360

 ctggcgggac gtttgccttg aaaatggaca aagacgccgc cctccggggt attcctgttt    420

 gcctgaccct gagagcgcct ttttgcttca agacgtgttg gatgctcctg ttctccgaat    480

 tctgatacgc ttctgggcat aatactgaaa cacaaaactg cttttgctct ctctgtggtt    540

 ggccgaaaat aggattcttt ttcgtgcagg tgtcgttgtt tagtcggctt tactaacata    600

 ttgaa    atg gct cta ccc aaa gac gcc atc ccc tcg ctg tcc gag tgc     647
          Met Ala Leu Pro Lys Asp Ala Ile Pro Ser Leu Ser Glu Cys
            1               5                  10

 cag tgc ggg atc tgc atg gaa atc ctc gtg gag ccc gtc acc ctc ccg      695
 Gln Cys Gly Ile Cys Met Glu Ile Leu Val Glu Pro Val Thr Leu Pro
  15                  20                  25                  30

 tgt aac cac acg ctg tgt aaa ccg tgc ttc cag tcg acc gtc gaa aag      743
 Cys Asn His Thr Leu Cys Lys Pro Cys Phe Gln Ser Thr Val Glu Lys
                  35                  40                  45

 gcg agt tta tgc tgt ccc ttc tgt cgc cgc cgg gta tcg tcg tgg act      791
 Ala Ser Leu Cys Cys Pro Phe Cys Arg Arg Arg Val Ser Ser Trp Thr
              50                  55                  60

 cgg tac cat acc cga aga aat tct ctc gtc aac gtg gaa ctg tgg acg      839
 Arg Tyr His Thr Arg Arg Asn Ser Leu Val Asn Val Glu Leu Trp Thr
          65                  70                  75

 ata att caa aaa cac tat ccc agg gag tgc aag ctt aga gcg tct ggc      887
 Ile Ile Gln Lys His Tyr Pro Arg Glu Cys Lys Leu Arg Ala Ser Gly
      80                  85                  90

 caa gaa tca gag gaa gtg gct gat gac tat cag cca gtt cgt ctg ctc      935
 Gln Glu Ser Glu Glu Val Ala Asp Asp Tyr Gln Pro Val Arg Leu Leu
  95                 100                 105                 110

 agt aaa cct ggg gaa ctg aga aga gaa tat gaa gag gaa ata agc aag      983
 Ser Lys Pro Gly Glu Leu Arg Arg Glu Tyr Glu Glu Glu Ile Ser Lys
                 115                 120                 125

 gtg gcg gca gag cga cgg gcc agc gag gaa gaa gaa aac aaa gcc agt     1031
 Val Ala Ala Glu Arg Arg Ala Ser Glu Glu Glu Glu Asn Lys Ala Ser
             130                 135                 140

 gaa gaa tac ata cag agg ttg ttg gca gag gag gaa gaa gag gaa aaa     1079
 Glu Glu Tyr Ile Gln Arg Leu Leu Ala Glu Glu Glu Glu Glu Glu Lys
         145                 150                 155

 aga cag gca gaa aaa agg cga aga gcg atg gaa gaa caa ctg aaa agt     1127
 Arg Gln Ala Glu Lys Arg Arg Arg Ala Met Glu Glu Gln Leu Lys Ser
     160                 165                 170

 gat gag gaa ctg gca aga aag cta agc att gat att aac aat ttc tgt     1175
 Asp Glu Glu Leu Ala Arg Lys Leu Ser Ile Asp Ile Asn Asn Phe Cys
 175                 180                 185                 190

 gag gga agt atc tcg gct tct ccc ttg aat tcc aga aaa tct gat cca     1223
 Glu Gly Ser Ile Ser Ala Ser Pro Leu Asn Ser Arg Lys Ser Asp Pro
                 195                 200                 205

 gtt aca ccc aag tct gaa aag aaa agt aag aac aaa caa aga aac act     1271
 Val Thr Pro Lys Ser Glu Lys Lys Ser Lys Asn Lys Gln Arg Asn Thr
             210                 215                 220

 gga gat att cag aag tat ttg aca ccg aaa tct cag ttt ggg tca gcc     1319
 Gly Asp Ile Gln Lys Tyr Leu Thr Pro Lys Ser Gln Phe Gly Ser Ala
         225                 230                 235

 tca cac tct gaa gct gta caa gaa gtc agg aaa gac tcc gta tct aag     1367
 Ser His Ser Glu Ala Val Gln Glu Val Arg Lys Asp Ser Val Ser Lys
     240                 245                 250

 gac att gac agt agt gat agg aaa agc cca aca ggg caa gac aca gaa     1415
 Asp Ile Asp Ser Ser Asp Arg Lys Ser Pro Thr Gly Gln Asp Thr Glu
 255                 260                 265                 270

 ata gaa gat atg ccg aca ctt tct cca cag ata tcc ctt gga gtt gga     1463
 Ile Glu Asp Met Pro Thr Leu Ser Pro Gln Ile Ser Leu Gly Val Gly
                 275                 280                 285

 gaa caa ggt gca cat tct tca ata gag ccc cct atg cca tgg ata tgt     1511
 Glu Gln Gly Ala His Ser Ser Ile Glu Pro Pro Met Pro Trp Ile Cys
             290                 295                 300

 gcc tgc ggt gcc gaa tgg tac cat gaa gga aac gtc aaa tca aga cca     1559
 Ala Cys Gly Ala Glu Trp Tyr His Glu Gly Asn Val Lys Ser Arg Pro
         305                 310                 315

 agc tat ctt ggg aaa gag ttt atg tga                                 1586
 Ser Tyr Leu Gly Lys Glu Phe Met 
     320                 325





      <210> 116
      <211> 765
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (2)..(679)

      <400> 116
 g    atg gca act ttt att gga gca gca gtg tcc aac agc agc aga ggt      46
      Met Ala Thr Phe Ile Gly Ala Ala Val Ser Asn Ser Ser Arg Gly
        1               5                  10                  15

 act gct cct tgt gga ata gga cta ccc cct agg cag cat gcc cag agt       94
 Thr Ala Pro Cys Gly Ile Gly Leu Pro Pro Arg Gln His Ala Gln Ser
                  20                  25                  30

 agc agc tca ggg gta att ctg tcg tca tat tta tac cca ctt tta att      142
 Ser Ser Ser Gly Val Ile Leu Ser Ser Tyr Leu Tyr Pro Leu Leu Ile
              35                  40                  45

 aca tgc aaa tta agg ggc agg tta ttc aga att ttc tgg aca aag gat      190
 Thr Cys Lys Leu Arg Gly Arg Leu Phe Arg Ile Phe Trp Thr Lys Asp
          50                  55                  60

 gat act tcc agg cca ttg cca tgg aaa ggg gtg gta act ttt agg tgt      238
 Asp Thr Ser Arg Pro Leu Pro Trp Lys Gly Val Val Thr Phe Arg Cys
      65                  70                  75

 tgc cat cac tgt ggt aaa ctg aca tgg tgt tgc tgg gta tgt ctc atg      286
 Cys His His Cys Gly Lys Leu Thr Trp Cys Cys Trp Val Cys Leu Met
  80                  85                  90                  95

 gag agg tgc ttt cac tgc ttc cct gtt cac cta gtc ttc aat ctg gtc      334
 Glu Arg Cys Phe His Cys Phe Pro Val His Leu Val Phe Asn Leu Val
                 100                 105                 110

 cag agt ttc agc ccc acc tct gga gtt gag tcc tgc ctt ctc cct caa      382
 Gln Ser Phe Ser Pro Thr Ser Gly Val Glu Ser Cys Leu Leu Pro Gln
             115                 120                 125

 tgt gac aaa tgt tgg cca atg gta tat cgc agt tgt gat gca agc aga      430
 Cys Asp Lys Cys Trp Pro Met Val Tyr Arg Ser Cys Asp Ala Ser Arg
         130                 135                 140

 ggc ttg gta aat gcc tgc ata ctg ggg ttt gtc ctc ttg gaa tgc tca      478
 Gly Leu Val Asn Ala Cys Ile Leu Gly Phe Val Leu Leu Glu Cys Ser
     145                 150                 155

 ttt gtg gga gcc ctg aac aac tat gta aga agt ctg gct acc ctg ctg      526
 Phe Val Gly Ala Leu Asn Asn Tyr Val Arg Ser Leu Ala Thr Leu Leu
 160                 165                 170                 175

 gag aga aca cat ggt ggg aag aga cta aaa tta tgt gaa gag agt cag      574
 Glu Arg Thr His Gly Gly Lys Arg Leu Lys Leu Cys Glu Glu Ser Gln
                 180                 185                 190

 gcc agc cat ccc agc ttc tct gct gag ccc cgc cat cag cca acc tgc      622
 Ala Ser His Pro Ser Phe Ser Ala Glu Pro Arg His Gln Pro Thr Cys
             195                 200                 205

 cag ctg aat gca acc gta aga gtg atc acc agc aag atc act aga aaa      670
 Gln Leu Asn Ala Thr Val Arg Val Ile Thr Ser Lys Ile Thr Arg Lys
         210                 215                 220

 acc acc taa ctgagcc caccctggat tgaacaatca taaacaaata aaatggttat      726
 Thr Thr 
     225

 tgttttaaat cacaaaaaaa aaaaaaaaaa aaaaagacg                           765




      <210> 117
      <211> 575
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (4)..(492)

      <400> 117
 cac  atg ttc att ttc agc tca agg cgt aca cgt gca ggt gtg tta cat      48
      Met Phe Ile Phe Ser Ser Arg Arg Thr Arg Ala Gly Val Leu His
        1               5                  10                  15

 gtt cat gtt tcg gct caa ggc gta cac gtg cag atg tgt cac agg ttc       96
 Val His Val Ser Ala Gln Gly Val His Val Gln Met Cys His Arg Phe
                  20                  25                  30

 atg ttc agc gca agg cgt aca cgt gca ggt gtg tta cat gtt cat ttt      144
 Met Phe Ser Ala Arg Arg Thr Arg Ala Gly Val Leu His Val His Phe
              35                  40                  45

 cgg ctc aag gcg tac acg tgc agg tgt gcc aca tgt tca ttt tcg gtt      192
 Arg Leu Lys Ala Tyr Thr Cys Arg Cys Ala Thr Cys Ser Phe Ser Val
          50                  55                  60

 caa ggc gta cac gtg cag gtg tgt tac gtg ttc att ttc ggc tca agg      240
 Gln Gly Val His Val Gln Val Cys Tyr Val Phe Ile Phe Gly Ser Arg
      65                  70                  75

 cgt aca cgt gca ggt gtg cca cat gtt tat ttt cgg ttc aag gcg tac      288
 Arg Thr Arg Ala Gly Val Pro His Val Tyr Phe Arg Phe Lys Ala Tyr
  80                  85                  90                  95

 acg tgc agg tgt gtt acg tgt tca ttt tcg gct caa ggc gta cac gtg      336
 Thr Cys Arg Cys Val Thr Cys Ser Phe Ser Ala Gln Gly Val His Val
                 100                 105                 110

 cag gtg tgt tac gtg ttc att ttc ggt tca agg cgt aca cgt gca ggt      384
 Gln Val Cys Tyr Val Phe Ile Phe Gly Ser Arg Arg Thr Arg Ala Gly
             115                 120                 125

 gtg tta cgt gtt cat ttt cgg ctc aag gcg tac acg tgc agg tgt gtc      432
 Val Leu Arg Val His Phe Arg Leu Lys Ala Tyr Thr Cys Arg Cys Val
         130                 135                 140

 aca tgg gta aat caa gtg tca ctg ggg ttt ggt gtg cag ata att ttg      480
 Thr Trp Val Asn Gln Val Ser Leu Gly Phe Gly Val Gln Ile Ile Leu
     145                 150                 155

 ttg ccc agg taa tca gcacagtacc tgatgttttt cagtcttcac cctcctccca      535
 Leu Pro Arg 
 160

 ttctccaccc tctacatttt cctttaaaaa aaagttttcc                          575




      <210> 118
      <211> 924
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (29)..(874)

      <400> 118
 ccccagctca cctcctcccc accccagc   atg gcc acg tct acc atg tcc gtc      52
                                  Met Ala Thr Ser Thr Met Ser Val
                                    1               5

 tgc tcc agc gct tac tct gac tcc tgg cag gtg gac gcc tgc cca gag      100
 Cys Ser Ser Ala Tyr Ser Asp Ser Trp Gln Val Asp Ala Cys Pro Glu
      10                  15                  20

 agc tgc tgt gag ccc ccc tgc tgt gcc ccc agc tgc tgc gcc ccg gcc      148
 Ser Cys Cys Glu Pro Pro Cys Cys Ala Pro Ser Cys Cys Ala Pro Ala
  25                  30                  35                  40

 ccc tgc ctg acc ctg gtc tgc acc cca gtg agc tgt gtg tcc agc ccc      196
 Pro Cys Leu Thr Leu Val Cys Thr Pro Val Ser Cys Val Ser Ser Pro
                  45                  50                  55

 tgc tgc cag gca gcc tgt gag ccc agc ccc tgc cag tca ggc tgc acc      244
 Cys Cys Gln Ala Ala Cys Glu Pro Ser Pro Cys Gln Ser Gly Cys Thr
              60                  65                  70

 agc tcc tgc acg ccc tcg tgc tgc cag cag tct agc tgc cag ccg gct      292
 Ser Ser Cys Thr Pro Ser Cys Cys Gln Gln Ser Ser Cys Gln Pro Ala
          75                  80                  85

 tac tgc acc tcc tcc ccc tgc cag cag gcc tgc tgc gtg ccc gtc tgc      340
 Tyr Cys Thr Ser Ser Pro Cys Gln Gln Ala Cys Cys Val Pro Val Cys
      90                  95                 100

 tgc aag cct gtg tgc tgc gtg ccc gtc tgc tgt ggg gct tct tcg tgc      388
 Cys Lys Pro Val Cys Cys Val Pro Val Cys Cys Gly Ala Ser Ser Cys
 105                 110                 115                 120

 tgc caa cag tct agc tac cag cca gct tgc tgt gcc tct tcc tcc tgc      436
 Cys Gln Gln Ser Ser Tyr Gln Pro Ala Cys Cys Ala Ser Ser Ser Cys
                 125                 130                 135

 cag ccg gcc tgc tgt gtg ccc gtc tgc tgc aaa cct gtg tgc tgt gcg      484
 Gln Pro Ala Cys Cys Val Pro Val Cys Cys Lys Pro Val Cys Cys Ala
             140                 145                 150

 ccc acc tgc tct gag gat tcc tat tca tgc tgc caa cag tct agc tgc      532
 Pro Thr Cys Ser Glu Asp Ser Tyr Ser Cys Cys Gln Gln Ser Ser Cys
         155                 160                 165

 cag cca gct tgc tgc act tcc tcc ccc tgc cag cag tcc tac tgt gtg      580
 Gln Pro Ala Cys Cys Thr Ser Ser Pro Cys Gln Gln Ser Tyr Cys Val
     170                 175                 180

 cct gtc tgc tgt aag cct gtc tgc tgc aaa ccc atc tgc tgt gtg cct      628
 Pro Val Cys Cys Lys Pro Val Cys Cys Lys Pro Ile Cys Cys Val Pro
 185                 190                 195                 200

 gtc tgc tct ggg gct tcc tct ttg tgc tgc cag cag tct ggc tgc cag      676
 Val Cys Ser Gly Ala Ser Ser Leu Cys Cys Gln Gln Ser Gly Cys Gln
                 205                 210                 215

 ccg gct tgc tgc acc acc tcc tgc tgc aga ccc tcc tcc tct gtg tcc      724
 Pro Ala Cys Cys Thr Thr Ser Cys Cys Arg Pro Ser Ser Ser Val Ser
             220                 225                 230

 ctc ctc tgc cgc cct gtg tgc agg ccc gcc tgc tgc gtg ccc gtc tcc      772
 Leu Leu Cys Arg Pro Val Cys Arg Pro Ala Cys Cys Val Pro Val Ser
         235                 240                 245

 tcc tgc tgt gcc cct gcc tcc tcc tac cag ccc agc tgc tgc cgc ccg      820
 Ser Cys Cys Ala Pro Ala Ser Ser Tyr Gln Pro Ser Cys Cys Arg Pro
     250                 255                 260

 gcc tcc tgc gtg tcc ctc ctc tgc cgc ccc gtg tgc tcc cgc ctg gcc      868
 Ala Ser Cys Val Ser Leu Leu Cys Arg Pro Val Cys Ser Arg Leu Ala
 265                 270                 275                 280

 tgc tga ggcctctgct caggccagga gtccagctgc tgatgtgcac atcccccagg       924
 Cys 






      <210> 119
      <211> 443
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (10)..(261)

      <400> 119
 gcacgagtg    atg atc ctt atc cta att ctt gag cat atc gtc acc tcc      48
              Met Ile Leu Ile Leu Ile Leu Glu His Ile Val Thr Ser
                1               5                  10

 aaa aga aac ccc aaa cct gtt aca gtc cct gct ttt ctg ccc cct tgc       96
 Lys Arg Asn Pro Lys Pro Val Thr Val Pro Ala Phe Leu Pro Pro Cys
      15                  20                  25

 ttg act tct ttc tct tgt tct gga gca tct ttc tct ctt ttt ggt ggg      144
 Leu Thr Ser Phe Ser Cys Ser Gly Ala Ser Phe Ser Leu Phe Gly Gly
  30                  35                  40                  45

 aga agg ggt tgg caa cat ggc agc tgc tgc tcc acc att ccc tta ttt      192
 Arg Arg Gly Trp Gln His Gly Ser Cys Cys Ser Thr Ile Pro Leu Phe
                  50                  55                  60

 cca act cta aat tcc ctt ggg cag gga ctc att ggc cca gcc tac ata      240
 Pro Thr Leu Asn Ser Leu Gly Gln Gly Leu Ile Gly Pro Ala Tyr Ile
              65                  70                  75

 ggt gcc ccc ctt gcc cga tga gc tgtgtccagg atgcacatgc tgtctggggg      293
 Gly Ala Pro Leu Ala Arg 
          80

 cccccactgt ggctggggag ggtgaagggg cagttctaag aagcctcgct aagcagatct    353

 gctaagagat ttcccttcag gctgggatct tagtgcacca ggcccatctg ttcagagatg    413

 aggaaacgga agtttaaaga tgcagggtta                                     443




      <210> 120
      <211> 603
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (1)..(498)

      <400> 120
  atg gtc aac tcc gtc gtc ttt ttt gac atc acc gtc gac ggc aag ccc      48
  Met Val Asn Ser Val Val Phe Phe Asp Ile Thr Val Asp Gly Lys Pro
    1               5                  10                  15

 ttg ggc cgc atc tcc atc aaa ctg ttt gca gac aag att cta aag aca       96
 Leu Gly Arg Ile Ser Ile Lys Leu Phe Ala Asp Lys Ile Leu Lys Thr
              20                  25                  30

 gcg gaa aac ttt cgt gct ctg agc act gga gag aaa gga ttt cgt tat      144
 Ala Glu Asn Phe Arg Ala Leu Ser Thr Gly Glu Lys Gly Phe Arg Tyr
          35                  40                  45

 aag ggt tcc tgc ttt cac aga att att cca ggg ttt atg tgt cag ggt      192
 Lys Gly Ser Cys Phe His Arg Ile Ile Pro Gly Phe Met Cys Gln Gly
      50                  55                  60

 ggt gac ttc aca cgc cat aat ggc act ggt ggc aag tcc atc tat ggg      240
 Gly Asp Phe Thr Arg His Asn Gly Thr Gly Gly Lys Ser Ile Tyr Gly
  65                  70                  75                  80

 gag aaa ttt gaa gat gag aac ttc atc cta aag cat acg ggt cct ggc      288
 Glu Lys Phe Glu Asp Glu Asn Phe Ile Leu Lys His Thr Gly Pro Gly
                  85                  90                  95

 atc ttg tcc atg gca aat gct gga ccc aac aca aat ggt tcc cag ttt      336
 Ile Leu Ser Met Ala Asn Ala Gly Pro Asn Thr Asn Gly Ser Gln Phe
             100                 105                 110

 ttc atc tgc act gcc aag act gag tgg ttg gat ggc aag cat gtg gtg      384
 Phe Ile Cys Thr Ala Lys Thr Glu Trp Leu Asp Gly Lys His Val Val
         115                 120                 125

 ttt ggc aaa gtg aaa gaa ggc atg aat att gtg gag gcc atg gag cgc      432
 Phe Gly Lys Val Lys Glu Gly Met Asn Ile Val Glu Ala Met Glu Arg
     130                 135                 140

 ttt ggg tcc agg aat ggc aag acc agc acg aag atc acc att gct gac      480
 Phe Gly Ser Arg Asn Gly Lys Thr Ser Thr Lys Ile Thr Ile Ala Asp
 145                 150                 155                 160

 tgt gga caa cat cga taa gtttga cttgtgtttt atcttaacca ccagatcatt      534
 Cys Gly Gln His Arg 
                 165

 ccttctgtag ctcaggagag cacccctgca ccccatttgc tcgcagatcc tagaatcttt    594

 gtgctctcc                                                            603




      <210> 121
      <211> 1028
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (477)..(839)

      <400> 121
 cgcgggagca gaacttgcag gacgacctgg attggtacca ggcgctggtg tggagccttc     60

 tggagggcga gcccagcatc tcccgggcgg ccatcacctt cagcaccgat tcgctgtccg    120

 caccggcccc acaggtcttc ctccaggcca cgcgcgagga gagccgcatc ctgctccaag    180

 acctgtcctc ctccgcaccc cacctggcca acgccactct ggagaccgag tggttccacg    240

 gcctccggcg caagtggagg ccccacttac accgccgcgg ccccaatcag gggccccggg    300

 gcctgggcca cagctggcgg cgcaaggacg ggctcggcgg ggacaagagc cacttcaagt    360

 ggtctccgcc ttatctggag tgcgagaacg ggagttacaa gcccgggtgg ctggttactc    420

 tttcctctgc catctacggg ttgcagccta acctggtccc ggaattcagg ggtgtc        476                                                                 
 atg aaa gtt gac ata aat ctt cag aaa gtg gac att gac caa tgc tca      524
 Met Lys Val Asp Ile Asn Leu Gln Lys Val Asp Ile Asp Gln Cys Ser
   1               5                  10                  15

 agt gat ggc tgg ttt tca gga act cat aaa tgc cac ctc aac aat tca      572
 Ser Asp Gly Trp Phe Ser Gly Thr His Lys Cys His Leu Asn Asn Ser
              20                  25                  30

 gag tgt atg cca att aaa ggc cta gga ttc gtt ctt gga gcc tat gag      620
 Glu Cys Met Pro Ile Lys Gly Leu Gly Phe Val Leu Gly Ala Tyr Glu
          35                  40                  45

 tgc att tgc aaa gca gga ttc tat cat cct gga gtc tta cca gtg aac      668
 Cys Ile Cys Lys Ala Gly Phe Tyr His Pro Gly Val Leu Pro Val Asn
      50                  55                  60

 aac ttt cgg aga agg ggt ccg gat cag cat att tca gga agt aca aaa      716
 Asn Phe Arg Arg Arg Gly Pro Asp Gln His Ile Ser Gly Ser Thr Lys
  65                  70                  75                  80

 gat gtg tca gaa gaa gcc tat gtc tgc cta cct tgc agg gag ggc tgc      764
 Asp Val Ser Glu Glu Ala Tyr Val Cys Leu Pro Cys Arg Glu Gly Cys
                  85                  90                  95

 ccc ttc tgt gct gat gac agc cca tgc ttc gtc cag gaa gat aag tat      812
 Pro Phe Cys Ala Asp Asp Ser Pro Cys Phe Val Gln Glu Asp Lys Tyr
             100                 105                 110

 tta cga ctt gcc atc att gcc ttc tag tattg cgccagctgg tgaaagtggg      864
 Leu Arg Leu Ala Ile Ile Ala Phe 
         115                 120

 aagcattgca aggggattac gttgtgtcac accagggagc tcccagtctc ggccttgtat    924

 cccgtacgga cagttcattg aaggtagttg gctctatagc agagctatgg cgtcgcaggc    984

 acgtgatgcc taaccgtacg tgtgggtcag cccggagaat tccg                    1028




      <210> 122
      <211> 475
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (101)..(448)

      <400> 122
 gccagcagca ggaggcagct gtacccatca ctgtcctcag agtactttta agaacaagga     60

 ggtctctgcc cacggcagcc caagcagatt cccatccatc  atg act gcc atc cga     115
                                              Met Thr Ala Ile Arg
                                                1               5

 cta cga gaa ttt att gag cgt cgc cca gtg atc ccg cca agt ata ttc      163
 Leu Arg Glu Phe Ile Glu Arg Arg Pro Val Ile Pro Pro Ser Ile Phe
                  10                  15                  20

 atc gct cac caa gga aga gac gtt caa ggc tat tac cct ggg cag ctg      211
 Ile Ala His Gln Gly Arg Asp Val Gln Gly Tyr Tyr Pro Gly Gln Leu
              25                  30                  35

 gca aga ctc cat ttt gat cat agt gca aag aga gct ccc aga cat tca      259
 Ala Arg Leu His Phe Asp His Ser Ala Lys Arg Ala Pro Arg His Ser
          40                  45                  50

 aag cct gcc gag cca tgg tat aaa gaa acc act tac cga cga gac tat      307
 Lys Pro Ala Glu Pro Trp Tyr Lys Glu Thr Thr Tyr Arg Arg Asp Tyr
      55                  60                  65

 tct ctg cca ttt tat gag att gat tgg aac cag aaa tta gcc aca gtt      355
 Ser Leu Pro Phe Tyr Glu Ile Asp Trp Asn Gln Lys Leu Ala Thr Val
  70                  75                  80                  85

 tcg ctg aat cct cga ccg ctt aat tca ctg cca gag ctc tac tgt tgt      403
 Ser Leu Asn Pro Arg Pro Leu Asn Ser Leu Pro Glu Leu Tyr Cys Cys
                  90                  95                 100

 gaa gag aga agc agc ttt gaa aga aat gct ttt aaa cta aaa taa cca      451
 Glu Glu Arg Ser Ser Phe Glu Arg Asn Ala Phe Lys Leu Lys 
             105                 110                 115

 cggcattcga acaaaaaaaa aaaa                                           475




      <210> 123
      <211> 1046
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (639)..(992)

      <220>
      <221> misc_feature
      <222> (1)...(1046)
      <223> n = a,t,c or g

      <400> 123
 cattngggga ttgcccccaa agaagtcttt ttgttgcccg ggggcgcgcc ctccggaatg     60

 aaaatgggga actcgcggcc cgcgccgtgt ggggttttgg ggtctcgaaa gtgtccttcc    120

 gcgttttctc cacaagcgtg tggggggccc cctccccgac atattctccg tggggccgcc    180

 ctaaccacgg tggggtgttc cacccagggg ggcgtgttgg aatacccgcg gggggctttt    240

 taaaccaggc tttttcacac gcggtgggcc ccacaaacaa ttctcccgca gagaatagag    300

 tttcgaggcc acagagtctc ttccaccgca cacgttctct ctggcaccgg ggtctctccg    360

 ctggaacgaa gaaggaaaat ctggcgcgcg aaggctgaag acgccaaggc gcgctaacct    420

 tgagcccctg aggcgcgcga ggccctggga agaaaccctg ggggcataca caacgcgcgc    480

 gagaacgggg acaaacaccg cggcgctttc acggcgagtt ccttcatcaa acaccttcgc    540

 gaattctctg aagaacacgc gggcccgaac ctggcggcgg ccaacccccc tggcaacaga    600

 cagaccgcgg gccgcgcgcc tggcgccaaa gctggttc    atg cgc aac gct ggt     653
                                              Met Arg Asn Ala Gly
                                                1               5

 gcc ccc cca agt tcc tgg gcg act cgc tgc tgc tgc tca act gcc tgt      701
 Ala Pro Pro Ser Ser Trp Ala Thr Arg Cys Cys Cys Ser Thr Ala Cys
                  10                  15                  20

 gcg agc tct cca agg agg acg gca agc ccc tct tcg cct ggt gag ccg      749
 Ala Ser Ser Pro Arg Arg Thr Ala Ser Pro Ser Ser Pro Gly Glu Pro
              25                  30                  35

 ccc cgc gcc cgc cgc ctt gcc tgc agt aaa cgc gtt tgt tcc aac ccg      797
 Pro Arg Ala Arg Arg Leu Ala Cys Ser Lys Arg Val Cys Ser Asn Pro
          40                  45                  50

 ggg ccg cgg tgc ctc ctg cgc gtc ccc ccg gag ggg aaa ggg ccg cgt      845
 Gly Pro Arg Cys Leu Leu Arg Val Pro Pro Glu Gly Lys Gly Pro Arg
      55                  60                  65

 ccc ccg cgc gcg agg cca gag aag gcc ccg ctc cca ccg gtg ctg ggc      893
 Pro Pro Arg Ala Arg Pro Glu Lys Ala Pro Leu Pro Pro Val Leu Gly
  70                  75                  80                  85

 ccc gac cgc agc ccg ccg ctg ccc gca cct gcg gag tgc ttc tca ccc      941
 Pro Asp Arg Ser Pro Pro Leu Pro Ala Pro Ala Glu Cys Phe Ser Pro
                  90                  95                 100

 ctc att aaa atc atc cgt ttg caa aaa aaa aaa aaa aaa gtg cct ttt      989
 Leu Ile Lys Ile Ile Arg Leu Gln Lys Lys Lys Lys Lys Val Pro Phe
             105                 110                 115

 taa aagt atcaagttta actgccgcgt gcaggcgact taatgttttt ttaataggcg     1046
 






      <210> 124
      <211> 1863
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (133)..(1863)

      <400> 124
 ggttgcgctt accttggcgt ctcctggccc cttgacgcgt caggttgctg tacccctgca     60

 taggatgcgc tgtaccctgc gctggctccg tgaaccttag ggacaacacc gggacacccg    120

 cgaggccgga aa    atg gac tca gtg gct ttt gag gat gtg tct gtg agc     168
                  Met Asp Ser Val Ala Phe Glu Asp Val Ser Val Ser
                    1               5                  10

 ttc agc cag gag gag tgg gct ctg ctg gct cct tca cag aag aaa ctc      216
 Phe Ser Gln Glu Glu Trp Ala Leu Leu Ala Pro Ser Gln Lys Lys Leu
          15                  20                  25

 tac aga gat gtg atg cag gaa aca ttc aag aac ctg gca tct ata ggg      264
 Tyr Arg Asp Val Met Gln Glu Thr Phe Lys Asn Leu Ala Ser Ile Gly
      30                  35                  40

 gaa aaa tgg gaa gac ccg aat gtt gaa gat caa cac aaa aac caa gga      312
 Glu Lys Trp Glu Asp Pro Asn Val Glu Asp Gln His Lys Asn Gln Gly
  45                  50                  55                  60

 cga aat cta aga agc cat acg gga gag aga ctc tgt gaa ggt aaa gaa      360
 Arg Asn Leu Arg Ser His Thr Gly Glu Arg Leu Cys Glu Gly Lys Glu
                  65                  70                  75

 ggt agt caa tgt gca gaa aac ttc agt ccc aat ctc agt gtg acg aag      408
 Gly Ser Gln Cys Ala Glu Asn Phe Ser Pro Asn Leu Ser Val Thr Lys
              80                  85                  90

 aag act gcc gga gta aaa cca tat gag tgt act atc tgt gga aaa gcc      456
 Lys Thr Ala Gly Val Lys Pro Tyr Glu Cys Thr Ile Cys Gly Lys Ala
          95                 100                 105

 ttc atg cgt ctc tca tcc ctt act aga cac atg agg tct cac act gga      504
 Phe Met Arg Leu Ser Ser Leu Thr Arg His Met Arg Ser His Thr Gly
     110                 115                 120

 tac gag cta ttt gag aag cca tat aaa tgt aag gag tgt gag aaa gcc      552
 Tyr Glu Leu Phe Glu Lys Pro Tyr Lys Cys Lys Glu Cys Glu Lys Ala
 125                 130                 135                 140

 ttt agt tat ctc aaa tcc ttt caa aga cat gaa agg agt cac act gga      600
 Phe Ser Tyr Leu Lys Ser Phe Gln Arg His Glu Arg Ser His Thr Gly
                 145                 150                 155

 gaa aaa ccc tat aaa tgt aaa caa tgt gga aaa acc ttc ata tat cac      648
 Glu Lys Pro Tyr Lys Cys Lys Gln Cys Gly Lys Thr Phe Ile Tyr His
             160                 165                 170

 cag ccc ttt caa aga cat gag cgg act cac att gga gaa aaa ccc tat      696
 Gln Pro Phe Gln Arg His Glu Arg Thr His Ile Gly Glu Lys Pro Tyr
         175                 180                 185

 gaa tgt aag caa tgt gga aaa gct ctt agt tgt tcc agt tcg ctt cga      744
 Glu Cys Lys Gln Cys Gly Lys Ala Leu Ser Cys Ser Ser Ser Leu Arg
     190                 195                 200

 gtt cat gaa agg att cac act gga gaa aag ccc tat gaa tgt aaa caa      792
 Val His Glu Arg Ile His Thr Gly Glu Lys Pro Tyr Glu Cys Lys Gln
 205                 210                 215                 220

 tgt ggg aaa gcc ttc agt tgt tcc agt tct att cga gta cac gaa aga      840
 Cys Gly Lys Ala Phe Ser Cys Ser Ser Ser Ile Arg Val His Glu Arg
                 225                 230                 235

 act cac act gga gag aaa ccc tat gca tgt aag gaa tgt ggg aaa gcc      888
 Thr His Thr Gly Glu Lys Pro Tyr Ala Cys Lys Glu Cys Gly Lys Ala
             240                 245                 250

 ttc att tcc cac aca agt gtt cta aca cac atg ata aca cac aac gga      936
 Phe Ile Ser His Thr Ser Val Leu Thr His Met Ile Thr His Asn Gly
         255                 260                 265

 gat aga cct tat aaa tgc aaa gaa tgt gga aag gca ttc att ttt ccc      984
 Asp Arg Pro Tyr Lys Cys Lys Glu Cys Gly Lys Ala Phe Ile Phe Pro
     270                 275                 280

 agt ttt tta cga gta cat gaa aga att cac act gga gag aaa ccc tat     1032
 Ser Phe Leu Arg Val His Glu Arg Ile His Thr Gly Glu Lys Pro Tyr
 285                 290                 295                 300

 aaa tgt aaa caa tgt ggt aaa gcc ttc aga tgt tcc acc tcc att caa     1080
 Lys Cys Lys Gln Cys Gly Lys Ala Phe Arg Cys Ser Thr Ser Ile Gln
                 305                 310                 315

 att cat gaa aga att cat act gga gag aag ccc tat aaa tgt aaa gaa     1128
 Ile His Glu Arg Ile His Thr Gly Glu Lys Pro Tyr Lys Cys Lys Glu
             320                 325                 330

 tgt ggg aaa tct ttc agt gca cgc cca gcc ttt cga gta cac gtg aga     1176
 Cys Gly Lys Ser Phe Ser Ala Arg Pro Ala Phe Arg Val His Val Arg
         335                 340                 345

 gtg cat act gga gag aaa ccc tat aag tgt aaa gaa tgt ggg aaa gcc     1224
 Val His Thr Gly Glu Lys Pro Tyr Lys Cys Lys Glu Cys Gly Lys Ala
     350                 355                 360

 ttt agt aga atc agt tac ttt cga ata cat gaa agg act cac act gga     1272
 Phe Ser Arg Ile Ser Tyr Phe Arg Ile His Glu Arg Thr His Thr Gly
 365                 370                 375                 380

 gag aaa ccc tac gaa tgt aaa aaa tgt ggg aaa act ttc aat tat cct     1320
 Glu Lys Pro Tyr Glu Cys Lys Lys Cys Gly Lys Thr Phe Asn Tyr Pro
                 385                 390                 395

 cta gat ttg aaa atc cac aag aga aat cac act gga gaa aaa ccc tat     1368
 Leu Asp Leu Lys Ile His Lys Arg Asn His Thr Gly Glu Lys Pro Tyr
             400                 405                 410

 gag tgt aag gaa tgt gca aaa acc ttc att tct ctt gag aac ttt cga     1416
 Glu Cys Lys Glu Cys Ala Lys Thr Phe Ile Ser Leu Glu Asn Phe Arg
         415                 420                 425

 aga cac atg atc acc cac act gga gac gga cct tat aaa tgt agg gac     1464
 Arg His Met Ile Thr His Thr Gly Asp Gly Pro Tyr Lys Cys Arg Asp
     430                 435                 440

 tgt ggg aag gtg ttc att ttt cct agt gcg tta cga aca cat gaa aga     1512
 Cys Gly Lys Val Phe Ile Phe Pro Ser Ala Leu Arg Thr His Glu Arg
 445                 450                 455                 460

 act cac act gga gag aaa ccc tat gaa tgt aaa caa tgt gga aaa gcc     1560
 Thr His Thr Gly Glu Lys Pro Tyr Glu Cys Lys Gln Cys Gly Lys Ala
                 465                 470                 475

 ttt agt tgt tct agt tac att cgg ata cat aaa aga act cac act ggg     1608
 Phe Ser Cys Ser Ser Tyr Ile Arg Ile His Lys Arg Thr His Thr Gly
             480                 485                 490

 gag aaa cct tat gaa tgt aag gaa tgc ggg aag gcc ttt att tat ccc     1656
 Glu Lys Pro Tyr Glu Cys Lys Glu Cys Gly Lys Ala Phe Ile Tyr Pro
         495                 500                 505

 aca agc ttt caa gga cac atg aga atg cat act gga gag aaa ccc tat     1704
 Thr Ser Phe Gln Gly His Met Arg Met His Thr Gly Glu Lys Pro Tyr
     510                 515                 520

 aaa tgt aaa gaa tgt ggg aag gcc ttt agt ctt cac agt tcc ttt caa     1752
 Lys Cys Lys Glu Cys Gly Lys Ala Phe Ser Leu His Ser Ser Phe Gln
 525                 530                 535                 540

 aga cat aca aga att cac aat tat gag aaa cct ctt gaa tgt aag caa     1800
 Arg His Thr Arg Ile His Asn Tyr Glu Lys Pro Leu Glu Cys Lys Gln
                 545                 550                 555

 tgt gga aaa gcc ttc agt gtg tcc aca tcc tta aaa aaa cat atg aga     1848
 Cys Gly Lys Ala Phe Ser Val Ser Thr Ser Leu Lys Lys His Met Arg
             560                 565                 570

 atg cac aat cga tag                                                 1863
 Met His Asn Arg 
         575





      <210> 125
      <211> 543
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (106)..(441)

      <400> 125
 ggaattcttc tggagacgac ttcacgacat gacaacagca tgggaaagac ccaccccatg     60

 atttagttac ctcccactag gcccctccca caacatgtgg tgatt    atg gga act     114
                                                      Met Gly Thr
                                                        1

 acg att ata gat ttg ggc ggg gac aca gcc aca cca tat caa tta ctg      162
 Thr Ile Ile Asp Leu Gly Gly Asp Thr Ala Thr Pro Tyr Gln Leu Leu
       5                  10                  15

 agc tgg gca tct tct ttc ttg aat gca cat tgg cct ctg agg cac ttc      210
 Ser Trp Ala Ser Ser Phe Leu Asn Ala His Trp Pro Leu Arg His Phe
  20                  25                  30                  35

 ctg gtt aac ctc att cca cag ctg aga aaa ccc agg ctt ggc aca ggc      258
 Leu Val Asn Leu Ile Pro Gln Leu Arg Lys Pro Arg Leu Gly Thr Gly
                  40                  45                  50

 aag gga tct gac cca acg tct ccc atc tta tta gtg gaa gga cca aga      306
 Lys Gly Ser Asp Pro Thr Ser Pro Ile Leu Leu Val Glu Gly Pro Arg
              55                  60                  65

 ctg gac cca caa cta tgc tcc tgt ttt gag tca cca tgc tgc cct caa      354
 Leu Asp Pro Gln Leu Cys Ser Cys Phe Glu Ser Pro Cys Cys Pro Gln
          70                  75                  80

 gat cag atc tca aaa caa gca gac atg ggg ggc tca gaa agt ccc cag      402
 Asp Gln Ile Ser Lys Gln Ala Asp Met Gly Gly Ser Glu Ser Pro Gln
      85                  90                  95

 cct aga act ttc ctg tca ccc aac gac act aag ggc taa gctggctgct       451
 Pro Arg Thr Phe Leu Ser Pro Asn Asp Thr Lys Gly 
 100                 105                 110

 tattattctg gattcacact agaatgacct tggggtgtgt ttcacacatg ccaatgtctg    511

 cagtttcacc cccagctaac tgactatgga tc                                  543






      <210> 126
      <211> 860
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (318)..(860)

      <400> 126
 atggcccagt cagctctcag tgaaagcctc catactgttc tcaccttcct aagggcccca     60

 gggtcaaggg tcaaaccaat agatgattcc atggcagttg gcagtcctga cagcaggctg    120

 gccctgatag ataacggaag tgaggaaggg tgagagttat ctatcttctc tgttttatag    180

 actacttcag cttctgctgt taccaatgcc tcagcaacca ctgaaagttc agatatcacc    240

 cttcttgtaa ctaatcaaat caaggaagag atctacaaaa tagtggtggt ggttccagct    300

 agaaattttc actcaca   atg gtg cat gtt tca aat aga agt atc cag ggt     350
                      Met Val His Val Ser Asn Arg Ser Ile Gln Gly
                        1               5                  10

 atg aac ata ctt ttc tcc tcc tgg gcc gta gtc tta atg gtg atg gga      398
 Met Asn Ile Leu Phe Ser Ser Trp Ala Val Val Leu Met Val Met Gly
              15                  20                  25

 atc acc tta gat aaa tgg gtt gaa ttg att tca gaa gat gaa aga gcc      446
 Ile Thr Leu Asp Lys Trp Val Glu Leu Ile Ser Glu Asp Glu Arg Ala
          30                  35                  40

 aag atg aac cac agt cct tgg atg atg tgt tgc cct gct ctt tgg cca      494
 Lys Met Asn His Ser Pro Trp Met Met Cys Cys Pro Ala Leu Trp Pro
      45                  50                  55

 gaa gat gac ctg aaa gtg gtc agg att atg atg acg tcg agc ctt ggc      542
 Glu Asp Asp Leu Lys Val Val Arg Ile Met Met Thr Ser Ser Leu Gly
  60                  65                  70                  75

 ctt tcc ttc ctc ctt aac tta atc ctg ggt atg aaa ttc acc tat ctg      590
 Leu Ser Phe Leu Leu Asn Leu Ile Leu Gly Met Lys Phe Thr Tyr Leu
                  80                  85                  90

 att cct caa aat aaa tat ata caa ctc ttc act acc atc ctc agt ttc      638
 Ile Pro Gln Asn Lys Tyr Ile Gln Leu Phe Thr Thr Ile Leu Ser Phe
              95                 100                 105

 ttc tca gga gtc ctc tct ctc cta gag tgc aag ttg tct acc agt agc      686
 Phe Ser Gly Val Leu Ser Leu Leu Glu Cys Lys Leu Ser Thr Ser Ser
         110                 115                 120

 tgt acc tgc ctg aac atc cat aaa tct gac aac gaa tgt aag gaa tct      734
 Cys Thr Cys Leu Asn Ile His Lys Ser Asp Asn Glu Cys Lys Glu Ser
     125                 130                 135

 gag aat tct atc gaa gat att tca tta cca gaa tgc act gca atg cct      782
 Glu Asn Ser Ile Glu Asp Ile Ser Leu Pro Glu Cys Thr Ala Met Pro
 140                 145                 150                 155

 cgt agc att gtc cgt gca cac act gtg aat tcc cta aac aaa aaa gtc      830
 Arg Ser Ile Val Arg Ala His Thr Val Asn Ser Leu Asn Lys Lys Val
                 160                 165                 170

 caa aca cgt cac gta acc tgg gct ctg tga                              860
 Gln Thr Arg His Val Thr Trp Ala Leu 
             175                 180





      <210> 127
      <211> 4023
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (718)..(4023)

      <400> 127
 atgcaagggt cctccatcat taacgcctct ttaataaaaa ctcttttcaa ggccacttta     60

 cttccaaagg aagctggagt cattcaatgc aagcaccatc aaaaggcatc agatcccatc    120

 attcagggca atgcttatgc tgataagact gtctccctgc aggagctgca gcaggacttt    180

 gagaatgcgc cccccaccga ccccaacaac aaccagaccc cggctaacgg caccagcgtg    240

 tcctatatca ccttcagccc tgacagctcc tcacctgccc agagtgagcc accagcctcc    300

 gctgaggccc ccggcgagcc cagtgacatg ctggccagcg tcccaccctt cgtcaccttc    360

 cacaccctca tcctggacat gagtggagtc agcttcgtgg acttgatggg catcaaggcc    420

 ctggccaagc tgagctccac ctatgggaag atcggcgtga aggtcttctt ggtgaacatc    480

 catgcccagg tgtacaatga cattagccat ggaggcgtct ttgaggatgg gagtctagaa    540

 tgcaagcacg tctttcccag catacatgac gcagtcctct ttgcccaggc aaatgctaga    600

 gacgtgaccc caggacacaa cttccaaggg gctccagggg atgctgagct ctccttgtac    660

 gactcagagg aggacattcg cagctactgg gacttagagc agatgggtct gggcttc       717                                                                 
 atg cag ttt ggc ttt gtg gcc atc tac ctc tcc gag tcc ttc atc cgg      765
 Met Gln Phe Gly Phe Val Ala Ile Tyr Leu Ser Glu Ser Phe Ile Arg
   1               5                  10                  15

 ggc ttc atg acg gcc gcc ggc ctg cag atc ctg att tcg gtg ctc aag      813
 Gly Phe Met Thr Ala Ala Gly Leu Gln Ile Leu Ile Ser Val Leu Lys
              20                  25                  30

 tac atc ttc gga ctg acc atc ccc tcc tac aca ggc cca ggg tcc atc      861
 Tyr Ile Phe Gly Leu Thr Ile Pro Ser Tyr Thr Gly Pro Gly Ser Ile
          35                  40                  45

 gtc ttt acc ttc att gac att tgc aaa aac ctc ccc cac acc aac atc      909
 Val Phe Thr Phe Ile Asp Ile Cys Lys Asn Leu Pro His Thr Asn Ile
      50                  55                  60

 gcc tcg ctc atc ttc gct ctc atc agc ggt gcc ttc ctg gtg ctg gtg      957
 Ala Ser Leu Ile Phe Ala Leu Ile Ser Gly Ala Phe Leu Val Leu Val
  65                  70                  75                  80

 aag gag ctc aat gct cgc tac atg cac aag att cgc ttc ccc atc cct     1005
 Lys Glu Leu Asn Ala Arg Tyr Met His Lys Ile Arg Phe Pro Ile Pro
                  85                  90                  95

 aca gag atg att gtg gtg gtg gtg gca aca gct atc tcc ggg ggc tgt     1053
 Thr Glu Met Ile Val Val Val Val Ala Thr Ala Ile Ser Gly Gly Cys
             100                 105                 110

 aag atg ccc aaa aag tat cac atg cag atc gtg gga gaa atc caa cgc     1101
 Lys Met Pro Lys Lys Tyr His Met Gln Ile Val Gly Glu Ile Gln Arg
         115                 120                 125

 ggg ttc ccc acc ccg gtg tcg cct gtg gtc tca cag tgg aag gac atg     1149
 Gly Phe Pro Thr Pro Val Ser Pro Val Val Ser Gln Trp Lys Asp Met
     130                 135                 140

 ata ggc aca gcc ttc tcc cta gcc atc gtg agc tac gtc atc aac ctg     1197
 Ile Gly Thr Ala Phe Ser Leu Ala Ile Val Ser Tyr Val Ile Asn Leu
 145                 150                 155                 160

 gct atg ggc cgg acc ctg gcc aac aag cac ggc tac gac gtg gat tcg     1245
 Ala Met Gly Arg Thr Leu Ala Asn Lys His Gly Tyr Asp Val Asp Ser
                 165                 170                 175

 aac cag gag atg atc gct ctc ggc tgc agc aac ttc ttt ggc tcc ttc     1293
 Asn Gln Glu Met Ile Ala Leu Gly Cys Ser Asn Phe Phe Gly Ser Phe
             180                 185                 190

 ttt aaa att cat gtc att tgc tgt gcg ctt tct gtc act ctg gct gtg     1341
 Phe Lys Ile His Val Ile Cys Cys Ala Leu Ser Val Thr Leu Ala Val
         195                 200                 205

 gat gga gct gga gga aaa tcc cag tct gtg cta gga gcc ctg atc gct     1389
 Asp Gly Ala Gly Gly Lys Ser Gln Ser Val Leu Gly Ala Leu Ile Ala
     210                 215                 220

 gtc aat ctc aag aac tcc ctc aag caa ctc acc gac ccc tac tac ctg     1437
 Val Asn Leu Lys Asn Ser Leu Lys Gln Leu Thr Asp Pro Tyr Tyr Leu
 225                 230                 235                 240

 tgg agg aag agc aag ctg gac tgt ctt gta aat gcc cca gat atg agc     1485
 Trp Arg Lys Ser Lys Leu Asp Cys Leu Val Asn Ala Pro Asp Met Ser
                 245                 250                 255

 cag ccc agg ccc cgc tac gtg gta gac aga gcc gca tac tcc ctt acc     1533
 Gln Pro Arg Pro Arg Tyr Val Val Asp Arg Ala Ala Tyr Ser Leu Thr
             260                 265                 270

 ctc ttc gac gat gag ttt gag aag aag gac cgg aca tac cca gtg gga     1581
 Leu Phe Asp Asp Glu Phe Glu Lys Lys Asp Arg Thr Tyr Pro Val Gly
         275                 280                 285

 gag aaa ctt cgc aat gcc ttc aga tgt tcc tca gcc aag atc aaa gct     1629
 Glu Lys Leu Arg Asn Ala Phe Arg Cys Ser Ser Ala Lys Ile Lys Ala
     290                 295                 300

 gtg gtg ttt ggg ctg ctg cct gtg ctc tcc tgg ctc ccc aag tac aag     1677
 Val Val Phe Gly Leu Leu Pro Val Leu Ser Trp Leu Pro Lys Tyr Lys
 305                 310                 315                 320

 att aaa gac tac atc att cct gac ctg ctc ggt gga ctc agc ggg gga     1725
 Ile Lys Asp Tyr Ile Ile Pro Asp Leu Leu Gly Gly Leu Ser Gly Gly
                 325                 330                 335

 tcc atc cag gtc cca caa ggc atg gca ttt gct ctg ctg gcc aac ctt     1773
 Ser Ile Gln Val Pro Gln Gly Met Ala Phe Ala Leu Leu Ala Asn Leu
             340                 345                 350

 cct gca gtc aat ggc ctc tac tcc tcc ttc ttc ccc ctc ctg acc tac     1821
 Pro Ala Val Asn Gly Leu Tyr Ser Ser Phe Phe Pro Leu Leu Thr Tyr
         355                 360                 365

 ttc ttc ctg ggg ggt gtt cac cag atg gtg cca ggt acc ttt gcc gtt     1869
 Phe Phe Leu Gly Gly Val His Gln Met Val Pro Gly Thr Phe Ala Val
     370                 375                 380

 atc agc atc ctg gtg ggt aac atc tgt ctg cag ctg gcc cca gag tcg     1917
 Ile Ser Ile Leu Val Gly Asn Ile Cys Leu Gln Leu Ala Pro Glu Ser
 385                 390                 395                 400

 aaa ttc cag gtc ttc aac aat gcc acc aat gag agc tat gtg gac aca     1965
 Lys Phe Gln Val Phe Asn Asn Ala Thr Asn Glu Ser Tyr Val Asp Thr
                 405                 410                 415

 gca gcc atg gag gct gag agg ctg cac gtg tca gct acg cta gcc tgc     2013
 Ala Ala Met Glu Ala Glu Arg Leu His Val Ser Ala Thr Leu Ala Cys
             420                 425                 430

 ctc acc gcc atc atc cag atg ggt ctg ggc ttc atg cag ttt ggc ttt     2061
 Leu Thr Ala Ile Ile Gln Met Gly Leu Gly Phe Met Gln Phe Gly Phe
         435                 440                 445

 gtg gcc atc tac ctc tcc gag tcc ttc atc cgg ggc ttc atg acg gcc     2109
 Val Ala Ile Tyr Leu Ser Glu Ser Phe Ile Arg Gly Phe Met Thr Ala
     450                 455                 460

 gcc ggc ctg cag atc ctg att tcg gtg ctc aag tac atc ttc gga ctg     2157
 Ala Gly Leu Gln Ile Leu Ile Ser Val Leu Lys Tyr Ile Phe Gly Leu
 465                 470                 475                 480

 acc atc ccc tcc tac aca ggc cca ggg tcc atc gtc ttt acc ttc att     2205
 Thr Ile Pro Ser Tyr Thr Gly Pro Gly Ser Ile Val Phe Thr Phe Ile
                 485                 490                 495

 gac att tgc aaa aac ctc ccc cac acc aac atc gcc tcg ctc atc ttc     2253
 Asp Ile Cys Lys Asn Leu Pro His Thr Asn Ile Ala Ser Leu Ile Phe
             500                 505                 510

 gct ctc atc agc ggt gcc ttc ctg gtg ctg gtg aag gag ctc aat gct     2301
 Ala Leu Ile Ser Gly Ala Phe Leu Val Leu Val Lys Glu Leu Asn Ala
         515                 520                 525

 cgc tac atg cac aag att cgc ttc ccc atc cct aca gag atg att gtg     2349
 Arg Tyr Met His Lys Ile Arg Phe Pro Ile Pro Thr Glu Met Ile Val
     530                 535                 540

 gtg gtg gtg gca aca gct atc tcc ggg ggc tgt aag atg ccc aaa aag     2397
 Val Val Val Ala Thr Ala Ile Ser Gly Gly Cys Lys Met Pro Lys Lys
 545                 550                 555                 560

 tat cac atg cag atc gtg gga gaa atc caa cgc ggg ttc ccc acc ccg     2445
 Tyr His Met Gln Ile Val Gly Glu Ile Gln Arg Gly Phe Pro Thr Pro
                 565                 570                 575

 gtg tcg cct gtg gtc tca cag tgg aag gac atg ata ggc aca gcc ttc     2493
 Val Ser Pro Val Val Ser Gln Trp Lys Asp Met Ile Gly Thr Ala Phe
             580                 585                 590

 tcc cta gcc atc gtg agc tac gtc atc aac ctg gct atg ggc cgg acc     2541
 Ser Leu Ala Ile Val Ser Tyr Val Ile Asn Leu Ala Met Gly Arg Thr
         595                 600                 605

 ctg gcc aac aag cac ggc tac gac gtg gat tcg aac cag gag atg atc     2589
 Leu Ala Asn Lys His Gly Tyr Asp Val Asp Ser Asn Gln Glu Met Ile
     610                 615                 620

 gct ctc ggc tgc agc aac ttc ttt ggc tcc ttc ttt aaa att cat gtc     2637
 Ala Leu Gly Cys Ser Asn Phe Phe Gly Ser Phe Phe Lys Ile His Val
 625                 630                 635                 640

 att tgc tgt gcg ctt tct gtc act ctg gct gtg gat gga gct gga gga     2685
 Ile Cys Cys Ala Leu Ser Val Thr Leu Ala Val Asp Gly Ala Gly Gly
                 645                 650                 655

 aaa tcc cag gtg gcc agc ctg tgt gtg tct ctg gtg gtg atg atc acc     2733
 Lys Ser Gln Val Ala Ser Leu Cys Val Ser Leu Val Val Met Ile Thr
             660                 665                 670

 atg ctg gtc ctg ggg atc tat ctg tat cct ctc cct aag tct gtg cta     2781
 Met Leu Val Leu Gly Ile Tyr Leu Tyr Pro Leu Pro Lys Ser Val Leu
         675                 680                 685

 gga gcc ctg atc gct gtc aat ctc aag aac tcc ctc aag caa ctc acc     2829
 Gly Ala Leu Ile Ala Val Asn Leu Lys Asn Ser Leu Lys Gln Leu Thr
     690                 695                 700

 gac ccc tac tac ctg tgg agg aag agc aag ctg gac tgt tgc atc tgg     2877
 Asp Pro Tyr Tyr Leu Trp Arg Lys Ser Lys Leu Asp Cys Cys Ile Trp
 705                 710                 715                 720

 gta gtg agc ttc ctc tcc tcc ttc ttc ctc agc ctg ccc tat ggt gtg     2925
 Val Val Ser Phe Leu Ser Ser Phe Phe Leu Ser Leu Pro Tyr Gly Val
                 725                 730                 735

 gca gtg ggt gtc gcc ttc tcc gtc ctg gtc gtg gtc ttc cag act cag     2973
 Ala Val Gly Val Ala Phe Ser Val Leu Val Val Val Phe Gln Thr Gln
             740                 745                 750

 ttt cga aat ggc tat gca ctg gcc cag gtc atg gac act gac att tat     3021
 Phe Arg Asn Gly Tyr Ala Leu Ala Gln Val Met Asp Thr Asp Ile Tyr
         755                 760                 765

 gtg aat ccc aag acc tat aat agg gcc cag gat atc cag ggg att aaa     3069
 Val Asn Pro Lys Thr Tyr Asn Arg Ala Gln Asp Ile Gln Gly Ile Lys
     770                 775                 780

 atc atc acg tac tgc tcc cct ctc tac ttt gcc aac tca gag atc ttc     3117
 Ile Ile Thr Tyr Cys Ser Pro Leu Tyr Phe Ala Asn Ser Glu Ile Phe
 785                 790                 795                 800

 agg caa aag gtc atc gcc aag aca ggc atg gac ccc cag aaa gta tta     3165
 Arg Gln Lys Val Ile Ala Lys Thr Gly Met Asp Pro Gln Lys Val Leu
                 805                 810                 815

 cta gcc aag caa aaa tac ctc aag aag cag gag aag cgg aga atg agg     3213
 Leu Ala Lys Gln Lys Tyr Leu Lys Lys Gln Glu Lys Arg Arg Met Arg
             820                 825                 830

 ccc aca caa cag agg agg tct cta ttc atg aaa acc aag act gtc tcc     3261
 Pro Thr Gln Gln Arg Arg Ser Leu Phe Met Lys Thr Lys Thr Val Ser
         835                 840                 845

 ctg cag gag ctg cag cag gac ttt gag aat gcg ccc ccc acc gac ccc     3309
 Leu Gln Glu Leu Gln Gln Asp Phe Glu Asn Ala Pro Pro Thr Asp Pro
     850                 855                 860

 aac aac aac cag acc ccg gct aac ggc acc agc gtg tcc tat atc acc     3357
 Asn Asn Asn Gln Thr Pro Ala Asn Gly Thr Ser Val Ser Tyr Ile Thr
 865                 870                 875                 880

 ttc agc cct gac agc tcc tca cct gcc cag agt gag cca cca gcc tcc     3405
 Phe Ser Pro Asp Ser Ser Ser Pro Ala Gln Ser Glu Pro Pro Ala Ser
                 885                 890                 895

 gct gag gcc ccc ggc gag ccc agt gac atg ctg gcc agc gtc cca ccc     3453
 Ala Glu Ala Pro Gly Glu Pro Ser Asp Met Leu Ala Ser Val Pro Pro
             900                 905                 910

 ttc gtc acc ttc cac acc ctc atc ctg gac atg agt gga gtc agc ttc     3501
 Phe Val Thr Phe His Thr Leu Ile Leu Asp Met Ser Gly Val Ser Phe
         915                 920                 925

 gtg gac ttg atg ggc atc aag gcc ctg gcc aag ctg agc tcc acc tat     3549
 Val Asp Leu Met Gly Ile Lys Ala Leu Ala Lys Leu Ser Ser Thr Tyr
     930                 935                 940

 ggg aag atc ggc gtg aag gtc ttc ttg gtg aac atc cat gcc cag gtg     3597
 Gly Lys Ile Gly Val Lys Val Phe Leu Val Asn Ile His Ala Gln Val
 945                 950                 955                 960

 tac aat gac att agc cat gga ggc gtc ttt gag gat ggg agt cta gaa     3645
 Tyr Asn Asp Ile Ser His Gly Gly Val Phe Glu Asp Gly Ser Leu Glu
                 965                 970                 975

 tgc aag cac gtc ttt ccc agc ata cat gac gca gtc ctc ttt gcc cag     3693
 Cys Lys His Val Phe Pro Ser Ile His Asp Ala Val Leu Phe Ala Gln
             980                 985                 990

 gca aat gct aga gac gtg acc cca gga cac aac ttc caa ggg gct cca     3741
 Ala Asn Ala Arg Asp Val Thr Pro Gly His Asn Phe Gln Gly Ala Pro
         995                1000                1005

 ggg gat gct gag ctc tcc ttg tac gac tca gag gag gac att cgc agc     3789
 Gly Asp Ala Glu Leu Ser Leu Tyr Asp Ser Glu Glu Asp Ile Arg Ser
    1010                1015                1020

 tac tgg gac tta gag cag gcc ctg gcc gca atg gac aag cct cct gct     3837
 Tyr Trp Asp Leu Glu Gln Ala Leu Ala Ala Met Asp Lys Pro Pro Ala
1025                1030                1035                1040

 cac tcc acc cca ccc aca tct gcc ctg tcc ttg gca gct gaa gga cac     3885
 His Ser Thr Pro Pro Thr Ser Ala Leu Ser Leu Ala Ala Glu Gly His
                1045                1050                1055

 ctt gac ttc cag ctt tta cga gtg agc caa aaa cag aag gac aag tac     3933
 Leu Asp Phe Gln Leu Leu Arg Val Ser Gln Lys Gln Lys Asp Lys Tyr
            1060                1065                1070

 aac tgt gct ggc ctg ctg tac aag ctt caa aaa gtg tcc cag agc ccg     3981
 Asn Cys Ala Gly Leu Leu Tyr Lys Leu Gln Lys Val Ser Gln Ser Pro
        1075                1080                1085

 cac ggc tcg gtg tca gat ggt gtc agg ctg tca cgg aca tag             4023
 His Gly Ser Val Ser Asp Gly Val Arg Leu Ser Arg Thr 
    1090                1095                1100





      <210> 128
      <211> 803
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (145)..(753)

      <400> 128
 gggtcttatc acggaggctg gggccaggca gcccttcggt tcgggtgggc ccatggaccc     60

 cagtccaacg ccgagggaat aggaccatcc aaaagcggaa ccttcgcctc agaaaaaggc    120

 gtggaccctg ccagcagcca ggcc   atg gag ctc tct gat gtc acc ctc att     171
                              Met Glu Leu Ser Asp Val Thr Leu Ile
                                1               5

 gag ggt gtg ggt aat gag gtg atg gtg gtg gca ggt gtg gtg gtg ctg      219
 Glu Gly Val Gly Asn Glu Val Met Val Val Ala Gly Val Val Val Leu
  10                  15                  20                  25

 att cta gcc ttg gtc cta gct tgg ctc tct acc tac gta gca gac agc      267
 Ile Leu Ala Leu Val Leu Ala Trp Leu Ser Thr Tyr Val Ala Asp Ser
                  30                  35                  40

 ggt agc aac cag ctc ctg ggc gct att gtc cct ggc ctc atc act gtg      315
 Gly Ser Asn Gln Leu Leu Gly Ala Ile Val Pro Gly Leu Ile Thr Val
              45                  50                  55

 cgg ctc aaa ttc ctc aat gat acc gag gag ctg gct gtg gct agg cca      363
 Arg Leu Lys Phe Leu Asn Asp Thr Glu Glu Leu Ala Val Ala Arg Pro
          60                  65                  70

 gag gat acc gtg ggt gcc ctg aag agc aaa tac ttc cct gga caa gaa      411
 Glu Asp Thr Val Gly Ala Leu Lys Ser Lys Tyr Phe Pro Gly Gln Glu
      75                  80                  85

 agc cag atg aaa ctg atc tac cag ggc cgc ctg cta caa gac cca gcc      459
 Ser Gln Met Lys Leu Ile Tyr Gln Gly Arg Leu Leu Gln Asp Pro Ala
  90                  95                 100                 105

 cgc aca ctg cgt tct ctg aac att acc gac aac tgt gtg att cac tgc      507
 Arg Thr Leu Arg Ser Leu Asn Ile Thr Asp Asn Cys Val Ile His Cys
                 110                 115                 120

 cac cgc tca ccc cca ggg tca gct gtt cca ggc ccc tca gcc tcc ttg      555
 His Arg Ser Pro Pro Gly Ser Ala Val Pro Gly Pro Ser Ala Ser Leu
             125                 130                 135

 gcc ccc tcg gcc act gag cca ccc agc ctt ggt gtc aat gtg ggc agc      603
 Ala Pro Ser Ala Thr Glu Pro Pro Ser Leu Gly Val Asn Val Gly Ser
         140                 145                 150

 ctc atg gtg cct gtc ttt gtg gtg ctg ttg ggt gtg gtc tgg tac ttc      651
 Leu Met Val Pro Val Phe Val Val Leu Leu Gly Val Val Trp Tyr Phe
     155                 160                 165

 cga atc aat tac cgc caa ttc ttc aca gca cct gcc act gtc tcc ctg      699
 Arg Ile Asn Tyr Arg Gln Phe Phe Thr Ala Pro Ala Thr Val Ser Leu
 170                 175                 180                 185

 gtg gga gtc acc gtc ttc ttc agc ttc cta gta ttt ggg atg tat gga      747
 Val Gly Val Thr Val Phe Phe Ser Phe Leu Val Phe Gly Met Tyr Gly
                 190                 195                 200

 cga taa ggacatagga agaaaatgaa agggtcctct gaaggagttc aaagctgctg       803
 Arg 






      <210> 129
      <211> 1047
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (1)..(474)

      <400> 129
  atg gct acg gca gcc ggc gcg acc tac ttt cag cga ggc agt ctg ttc      48
  Met Ala Thr Ala Ala Gly Ala Thr Tyr Phe Gln Arg Gly Ser Leu Phe
    1               5                  10                  15

 tgg ttc aca gtc atc acc ctc agc ttt ggc tac tac aca agg atg gtg       96
 Trp Phe Thr Val Ile Thr Leu Ser Phe Gly Tyr Tyr Thr Arg Met Val
              20                  25                  30

 aag tcg gag gcc agc aat gcg gct acc gcc tat ttc cgt cca gca aga      144
 Lys Ser Glu Ala Ser Asn Ala Ala Thr Ala Tyr Phe Arg Pro Ala Arg
          35                  40                  45

 ccc ttg ccc tct ctg gtc aca gtc ctg ggg ctg ggc tac ttc gcg tgg      192
 Pro Leu Pro Ser Leu Val Thr Val Leu Gly Leu Gly Tyr Phe Ala Trp
      50                  55                  60

 gtt gtc ttc tgg cct cag agt atc cct tat cag aac ctt ggg ccc ctg      240
 Val Val Phe Trp Pro Gln Ser Ile Pro Tyr Gln Asn Leu Gly Pro Leu
  65                  70                  75                  80

 ggc ccc ttc act cag tac ttg gtg gac cac cat cac acc ctc ctt tgc      288
 Gly Pro Phe Thr Gln Tyr Leu Val Asp His His His Thr Leu Leu Cys
                  85                  90                  95

 aat ggg tat tgg ctt gcc tgg ctg att cat gtg gga gag tcc ttg tat      336
 Asn Gly Tyr Trp Leu Ala Trp Leu Ile His Val Gly Glu Ser Leu Tyr
             100                 105                 110

 gcc ata gta ttg tgc aag cat aaa ggc atc aca agt ggt cgg gct cag      384
 Ala Ile Val Leu Cys Lys His Lys Gly Ile Thr Ser Gly Arg Ala Gln
         115                 120                 125

 cta ctc tgg ttc cta cag act ttc ttc ttt ggg ata gcg tct ctc acc      432
 Leu Leu Trp Phe Leu Gln Thr Phe Phe Phe Gly Ile Ala Ser Leu Thr
     130                 135                 140

 atc ttg att gct tac aaa cgg aag cgc caa aaa caa act tga agttgtc      481
 Ile Leu Ile Ala Tyr Lys Arg Lys Arg Gln Lys Gln Thr 
 145                 150                 155

 tgaaagcttg ctctacactt ttacattcat cctcaccctt ttttttgtgg ggtagaggag    541

 gtgcagtaat ttactcagtg atctttctac tttctagaaa ctgtccttca aagctcttta    601

 agaccccctc gttagtcagt tttttctctt atatgctctg gttgagcttg aatagaccag    661

 ttgttactta agaaagaaac cagagaaaga ttttagcctt tccaatccta ttggccggag    721

 gatctccagc gtccttcttc acggtccttg gctgtgttgg gacccttggg tgtcttggct    781

 atgccacttc gtagactggc ctttgggagg gatccctggc tccggcctcc tgatgtaaac    841

 ccttccctcg acgcacatct tcggttcctt caagcctttc ccccgtggct cgaataaggg    901

 ccctccctct tgcatcccgc tttttgtccg cggtggacta tcttacctct tccgtccgac    961

 gggatgaaga acccccgtat gtcggttgat atcttagggg cgtggggatg tgcctacgcg   1021

 gactcgcgcg accttgtgag ggttcc                                        1047




      <210> 130
      <211> 2057
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (652)..(1119)

      <220>
      <221> misc_feature
      <222> (1)...(2057)
      <223> n = a,t,c or g

      <400> 130
 tagagcctgg gggagagtgg atccatttga agggggcaga gggcttgagt cagtgtgaga     60

 atcgggggat gggtgagata tctccctcca gcagcagcac ttaggccaca ttaccctctg    120

 aggaatccac atttgtctta gatagttacc tgtgcaggga tcagnccatt tattcctatt    180

 ttctctgaca gctggatgaa agggactggg agttttcgtc ctcttgaata agaactcgac    240

 aacagagtgg gaactttctg tcttgtgatc cattgcctgg tgagtcacag ctcacaccat    300

 ggatttaacc tgagagcttc aacttctgct ttggccctgg agttcccatg ccctggtgtc    360

 ttctaccagt tcttaggtag ggttttgtat ccagagaggg ttcatctttc tcccgtgggc    420

 tgggggaaga ggtcaaagta gaactcaggt accaaatttg aaaggaaaca ctcagaaaaa    480

 acttctgagc gcagagcgga aaacaccctc tcagtcccca ccaaagagaa aagctttggg    540

 ttctaaattt ccagtttcca ttaagggact ctgggactgg acatttctga aaattaatga    600

 cctgtactga gtaatcctcc taacacactg atcatcaaaa aataacctgt a atg agt     657
                                                          Met Ser
                                                            1

 tta ggc ttt ctg tat ttg tct gaa tgc ttt cac ggg agt gtg ttg cac      705
 Leu Gly Phe Leu Tyr Leu Ser Glu Cys Phe His Gly Ser Val Leu His
           5                  10                  15

 tgg agc aca gag gac act cga tcg tgc ggc gcg caa ggc ggg ggg ccg      753
 Trp Ser Thr Glu Asp Thr Arg Ser Cys Gly Ala Gln Gly Gly Gly Pro
      20                  25                  30

 ccg ctg cct ccc cgc ggg atg gct ggc act gtg ctc gga gtc ggt gcg      801
 Pro Leu Pro Pro Arg Gly Met Ala Gly Thr Val Leu Gly Val Gly Ala
  35                  40                  45                  50

 ggc gtg ttc atc tta gcc ctg atc tgg gtg gca gtg ctg ctg ctg tgt      849
 Gly Val Phe Ile Leu Ala Leu Ile Trp Val Ala Val Leu Leu Leu Cys
                  55                  60                  65

 gtg ctg ctg tcc aga gcc tcc ggg gcg gcg agg ttc tct gtc att ttt      897
 Val Leu Leu Ser Arg Ala Ser Gly Ala Ala Arg Phe Ser Val Ile Phe
              70                  75                  80

 tta ttc ttc ggt gct gtg atc atc aca tca gtt ctg ttg ctt ttc ccg      945
 Leu Phe Phe Gly Ala Val Ile Ile Thr Ser Val Leu Leu Leu Phe Pro
          85                  90                  95

 cga gct ggt gaa ttc cca gcc cca gaa gtg gaa gtt aag att gtg gat      993
 Arg Ala Gly Glu Phe Pro Ala Pro Glu Val Glu Val Lys Ile Val Asp
     100                 105                 110

 gac ttt ttc att ggc cgc tat gtc ctg ctg gct ttc ctt agt gcc atc     1041
 Asp Phe Phe Ile Gly Arg Tyr Val Leu Leu Ala Phe Leu Ser Ala Ile
 115                 120                 125                 130

 ttc ctt gga ggc ctc ttc ttg gtt tta atc cat tat gtt ctg gag ccg     1089
 Phe Leu Gly Gly Leu Phe Leu Val Leu Ile His Tyr Val Leu Glu Pro
                 135                 140                 145

 atc tat gcc aaa cca ctg cac tcc tac tga c cactcttcag gaaaacgaaa     1140
 Ile Tyr Ala Lys Pro Leu His Ser Tyr 
             150                 155

 acctgttctc tccttcattg tgatgacatt gatgagcagg aaggcactat tcagagcctt   1200

 gttttgacag ccctcatgcc ttaaggttag aggagtatct gtccatcact aagacaaatc   1260

 tctggagtcc tggcttccag aaacaggatt gccaaattgt ccctgtgggg ctagattctt   1320

 accagcttaa gaaggatatt gctatcttct tagtacccgt accttaggat ttccaactgt   1380

 tttgaaaggg aaatagtaac agtgatctgc ttagagtgga ttttcactca agtccttagt   1440

 aagtggattt tggggaaaaa agcacatggg cttctggttc tttttgataa tatataaaat   1500

 tattcattat gaggttgcag ttgtttgcaa aggagaggca ctcaaatttg aaaggttatt   1560

 ttaatgtgat aatttggaag acttactcag atgttggtca ttgaccactc tgtgcatata   1620

 tttctgcaga gctctgtgaa ggcaatgagt gtcacttccc tctgctctaa taaagcaata   1680

 aataatagct aaagggctga ctttcacttc gaactcttgg ccacggcttt ttaatcaagt   1740

 tctttaggtt tccttgggat tagaggaaag gtatggaaat attgtttttt gttttttgtc   1800

 ttgccatgta tctgtaggtt tttttcttcc atgatgtggt gggctgtgtg tgccttattt   1860

 aattaccatg agtccatttg gggtgtcttc acttttcatc tttgtagccc tttctccaaa   1920

 gctagtgagg aaggtatatt ctcaacatca gatataactc tatacctgtc tgatctccca   1980

 gaccaaactg aaatttgcat taaatggagg ggcccctggt caggttccac ttggaagtct   2040

 gatctgaatc ctagagc                                                  2057




      <210> 131
      <211> 2753
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (417)..(2753)

      <400> 131
 ggcggggccg ccgtcgaggc tggcgccaga tttcgattgg ctgtgggtcc tgcagcttca     60

 gagaaaggag gccttctgtc actcgtcact agctcgctcg ctcactgggg gaggagcccg    120

 cctgaggaat ccgtgtgcct gggatgccaa gagccagaga atggatcttc tccgagtggg    180

 gacattgctg acaatcccgg cttcccgagg cggctaagaa caggcagttt gtgtcggctg    240

 gctgcagata cccagaggca caaagagacc gaagccaccc ggagggaccc acggacggac    300

 agatggtagg cgcgaacccg agaggaccgg cggaggctga gcaccgagag ccgccaagga    360

 agagaaacta accacagcca agttaccccg ccggctttcc ttcgctgcgc taagga        416                                                                 
 atg aaa ccc ttc cag ctc gat ctg ctc ttc gtc tgc ttc ttc ctc ttc      464
 Met Lys Pro Phe Gln Leu Asp Leu Leu Phe Val Cys Phe Phe Leu Phe
   1               5                  10                  15

 agt caa gag ctg ggc ctc cag aag aga gga tgc tgt ctg gtg ctg ggc      512
 Ser Gln Glu Leu Gly Leu Gln Lys Arg Gly Cys Cys Leu Val Leu Gly
              20                  25                  30

 tac atg gcc aag gac aag ttt cgg aga atg aat gaa ggc caa gtc tat      560
 Tyr Met Ala Lys Asp Lys Phe Arg Arg Met Asn Glu Gly Gln Val Tyr
          35                  40                  45

 tcc ttc agc cag cag ccc cag gac cag gtg gtg gtg tcg gga cag cca      608
 Ser Phe Ser Gln Gln Pro Gln Asp Gln Val Val Val Ser Gly Gln Pro
      50                  55                  60

 gtg acg cta ctt tgc gcc atc ccc gaa tac gat ggc ttc gtt ctg tgg      656
 Val Thr Leu Leu Cys Ala Ile Pro Glu Tyr Asp Gly Phe Val Leu Trp
  65                  70                  75                  80

 atc aag gac ggc ttg gct ctg ggt gtg ggc agg gac ctc tca agt tac      704
 Ile Lys Asp Gly Leu Ala Leu Gly Val Gly Arg Asp Leu Ser Ser Tyr
                  85                  90                  95

 cca cag tac ctg gtg gta ggg aac cac ctg tca ggg gag cac cac ctg      752
 Pro Gln Tyr Leu Val Val Gly Asn His Leu Ser Gly Glu His His Leu
             100                 105                 110

 aag atc ctg agg gca gag ctg caa gac gat gcg gtg tac gag tgc cag      800
 Lys Ile Leu Arg Ala Glu Leu Gln Asp Asp Ala Val Tyr Glu Cys Gln
         115                 120                 125

 gcc atc cag gcc gcc atc cgc tcc cgc ccc gca cgc ctc aca gtc ctg      848
 Ala Ile Gln Ala Ala Ile Arg Ser Arg Pro Ala Arg Leu Thr Val Leu
     130                 135                 140

 gtg ccg cct gat gac ccc gtc atc ctg ggg ggc cct gtg atc agc ctg      896
 Val Pro Pro Asp Asp Pro Val Ile Leu Gly Gly Pro Val Ile Ser Leu
 145                 150                 155                 160

 cgt gcg ggg gac cct ctc aac ctc acc tgc cac gca gac aat gcc aag      944
 Arg Ala Gly Asp Pro Leu Asn Leu Thr Cys His Ala Asp Asn Ala Lys
                 165                 170                 175

 cct gca gcc tcc atc atc tgg ttg cga aag gga gag gtc atc aat ggg      992
 Pro Ala Ala Ser Ile Ile Trp Leu Arg Lys Gly Glu Val Ile Asn Gly
             180                 185                 190

 gcc acc tac tcc aag acc ctg ctt cgg gac ggc aag cgg gag agc atc     1040
 Ala Thr Tyr Ser Lys Thr Leu Leu Arg Asp Gly Lys Arg Glu Ser Ile
         195                 200                 205

 gtc agc acc ctc ttc atc tcc cct ggt gac gtg gag aat ggc cag agc     1088
 Val Ser Thr Leu Phe Ile Ser Pro Gly Asp Val Glu Asn Gly Gln Ser
     210                 215                 220

 atc gtg tgt cgt gcc acc aac aaa gcc atc ccc gga gga aag gag acg     1136
 Ile Val Cys Arg Ala Thr Asn Lys Ala Ile Pro Gly Gly Lys Glu Thr
 225                 230                 235                 240

 tcg gtc acc att gac atc cag cac cct cca ctg gtc aac ctc tcg gtg     1184
 Ser Val Thr Ile Asp Ile Gln His Pro Pro Leu Val Asn Leu Ser Val
                 245                 250                 255

 gag cca cag cca gtg ctg gag gac aac gtc gtc act ttc cac tgc tct     1232
 Glu Pro Gln Pro Val Leu Glu Asp Asn Val Val Thr Phe His Cys Ser
             260                 265                 270

 gca aag gcc aac cca gct gtc acc cag tac agg tgg gcc aag cgg ggc     1280
 Ala Lys Ala Asn Pro Ala Val Thr Gln Tyr Arg Trp Ala Lys Arg Gly
         275                 280                 285

 cag atc atc aag gag gca tct gga gag gtg tac agg acc aca gtg gac     1328
 Gln Ile Ile Lys Glu Ala Ser Gly Glu Val Tyr Arg Thr Thr Val Asp
     290                 295                 300

 tac acg tac ttc tca gag ccc gtc tcc tgt gag gtg acc aac gcc ctg     1376
 Tyr Thr Tyr Phe Ser Glu Pro Val Ser Cys Glu Val Thr Asn Ala Leu
 305                 310                 315                 320

 ggc agc acc aac ctc agc cgc acg gtt gac gtc tac ttt ggg ccc cgg     1424
 Gly Ser Thr Asn Leu Ser Arg Thr Val Asp Val Tyr Phe Gly Pro Arg
                 325                 330                 335

 atg acc aca gaa ccc caa tcc ttg ctc gtg gat ctg ggc tct gat gcc     1472
 Met Thr Thr Glu Pro Gln Ser Leu Leu Val Asp Leu Gly Ser Asp Ala
             340                 345                 350

 atc ttc agc tgc gcc tgg acc ggc aac cca tcc ctg acc atc gtc tgg     1520
 Ile Phe Ser Cys Ala Trp Thr Gly Asn Pro Ser Leu Thr Ile Val Trp
         355                 360                 365

 atg aag cgg ggc tcc gga gtg gtc ctg agc aat gag aag acc ctg acc     1568
 Met Lys Arg Gly Ser Gly Val Val Leu Ser Asn Glu Lys Thr Leu Thr
     370                 375                 380

 ctc aaa tcc gtg cgc cag gag gac gcg ggc aag tac gtg tgc cgg gct     1616
 Leu Lys Ser Val Arg Gln Glu Asp Ala Gly Lys Tyr Val Cys Arg Ala
 385                 390                 395                 400

 gtg gtg ccc cgt gtg gga gcc ggg gag aga gag gtg acc ctg acc gtc     1664
 Val Val Pro Arg Val Gly Ala Gly Glu Arg Glu Val Thr Leu Thr Val
                 405                 410                 415

 aat gga ccc ccc atc atc tcc agc acc cag acc cag cac gcc ctc cac     1712
 Asn Gly Pro Pro Ile Ile Ser Ser Thr Gln Thr Gln His Ala Leu His
             420                 425                 430

 ggc gag aag ggc cag atc aag tgc ttc atc cgg agc acg ccg ccg ccg     1760
 Gly Glu Lys Gly Gln Ile Lys Cys Phe Ile Arg Ser Thr Pro Pro Pro
         435                 440                 445

 gac cgc atc gcc tgg tcc tgg aag gag aac gtt ctg gag tcg ggc aca     1808
 Asp Arg Ile Ala Trp Ser Trp Lys Glu Asn Val Leu Glu Ser Gly Thr
     450                 455                 460

 tcg ggg cgc tat acg gtg gag acc atc agc acc gag gag ggc gtc atc     1856
 Ser Gly Arg Tyr Thr Val Glu Thr Ile Ser Thr Glu Glu Gly Val Ile
 465                 470                 475                 480

 tcc acc ctg acc atc agc aac atc gtg cgg gcc gac ttc cag acc atc     1904
 Ser Thr Leu Thr Ile Ser Asn Ile Val Arg Ala Asp Phe Gln Thr Ile
                 485                 490                 495

 tac aac tgc acg gcc tgg aac agc ttc ggc tcc gac act gag atc atc     1952
 Tyr Asn Cys Thr Ala Trp Asn Ser Phe Gly Ser Asp Thr Glu Ile Ile
             500                 505                 510

 cgg ctc aag gag caa ggt tcg gaa atg aag tcg gga gcc ggg ctg gaa     2000
 Arg Leu Lys Glu Gln Gly Ser Glu Met Lys Ser Gly Ala Gly Leu Glu
         515                 520                 525

 gca gag tct gtg ccg atg gcc gtc atc att ggg gtg gcc gta gga gct     2048
 Ala Glu Ser Val Pro Met Ala Val Ile Ile Gly Val Ala Val Gly Ala
     530                 535                 540

 ggt gtg gcc ttc ctc gtc ctt atg gca acc atc gtg gcg ttc tgc tgt     2096
 Gly Val Ala Phe Leu Val Leu Met Ala Thr Ile Val Ala Phe Cys Cys
 545                 550                 555                 560

 gcc cgt tcc cag aga aat ctc aaa ggt gtt gtg tca gcc aaa aat gat     2144
 Ala Arg Ser Gln Arg Asn Leu Lys Gly Val Val Ser Ala Lys Asn Asp
                 565                 570                 575

 atc cga gtg gaa att gtc cac aag gaa cca gcc tct ggt cgg gag ggt     2192
 Ile Arg Val Glu Ile Val His Lys Glu Pro Ala Ser Gly Arg Glu Gly
             580                 585                 590

 gag gag cac tcc acc atc aag cag ctg atg atg gac cgg ggt gaa ttc     2240
 Glu Glu His Ser Thr Ile Lys Gln Leu Met Met Asp Arg Gly Glu Phe
         595                 600                 605

 cag caa gac tca gtc ctg aaa cag ctg gag gtc ctc aaa gaa gag gag     2288
 Gln Gln Asp Ser Val Leu Lys Gln Leu Glu Val Leu Lys Glu Glu Glu
     610                 615                 620

 aaa gag ttt cag aac ctg aag gac ccc acc aat ggc tac tac agc gtc     2336
 Lys Glu Phe Gln Asn Leu Lys Asp Pro Thr Asn Gly Tyr Tyr Ser Val
 625                 630                 635                 640

 aac acc ttc aaa gag cac cac tca acc ccg acc atc tcc ctc tcc agc     2384
 Asn Thr Phe Lys Glu His His Ser Thr Pro Thr Ile Ser Leu Ser Ser
                 645                 650                 655

 tgc cag ccc gac ctg cgt cct gcg ggc aag cag cgt gtg ccc aca ggc     2432
 Cys Gln Pro Asp Leu Arg Pro Ala Gly Lys Gln Arg Val Pro Thr Gly
             660                 665                 670

 atg tcc ttc acc aac atc tac agc acc ctg agc ggc cag ggc cgc ctc     2480
 Met Ser Phe Thr Asn Ile Tyr Ser Thr Leu Ser Gly Gln Gly Arg Leu
         675                 680                 685

 tac gac tac ggg cag cgg ttt gtg ctg ggc atg ggc agc tcg tcc atc     2528
 Tyr Asp Tyr Gly Gln Arg Phe Val Leu Gly Met Gly Ser Ser Ser Ile
     690                 695                 700

 gag ctt tgt gag cgg gag ttc cag aga ggc tcc ctc agc gac agc agc     2576
 Glu Leu Cys Glu Arg Glu Phe Gln Arg Gly Ser Leu Ser Asp Ser Ser
 705                 710                 715                 720

 tcc ttc ctg gac acg cag tgt gac agc agc gtc agc agc agc ggc aag     2624
 Ser Phe Leu Asp Thr Gln Cys Asp Ser Ser Val Ser Ser Ser Gly Lys
                 725                 730                 735

 cag gat ggc tat gtg cag ttc gac aag gcc agc aag gct tct gct tcc     2672
 Gln Asp Gly Tyr Val Gln Phe Asp Lys Ala Ser Lys Ala Ser Ala Ser
             740                 745                 750

 tcc tcc cac cac tcc cag tcc tcg tcc cag aac tct gac ccc agt cga     2720
 Ser Ser His His Ser Gln Ser Ser Ser Gln Asn Ser Asp Pro Ser Arg
         755                 760                 765

 ccc ctg cag cgg cgg atg cag act cac gtc taa                         2753
 Pro Leu Gln Arg Arg Met Gln Thr His Val 
     770                 775





      <210> 132
      <211> 573
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (1)..(573)

      <400> 132
  atg gtg ctg tgg gtc aga gct ggg gca tgg ccc agg gat tca gtg tgc      48
  Met Val Leu Trp Val Arg Ala Gly Ala Trp Pro Arg Asp Ser Val Cys
    1               5                  10                  15

 ctt gac tcc ccc tgt aaa tgt tcc tct cag aag cct tct tgg cct tcc       96
 Leu Asp Ser Pro Cys Lys Cys Ser Ser Gln Lys Pro Ser Trp Pro Ser
              20                  25                  30

 agc cct tgg ttt ttg aga caa cca gca gtc att tgt tcg ttc ctg aca      144
 Ser Pro Trp Phe Leu Arg Gln Pro Ala Val Ile Cys Ser Phe Leu Thr
          35                  40                  45

 ttc ctt cct gtc cct tcc ttc cag gtt ctg tgg aca atc aca atg gga      192
 Phe Leu Pro Val Pro Ser Phe Gln Val Leu Trp Thr Ile Thr Met Gly
      50                  55                  60

 atc caa gga ggg tct gtc ctg ttc ggg ctg ctg ctc gtc ctg gct gtc      240
 Ile Gln Gly Gly Ser Val Leu Phe Gly Leu Leu Leu Val Leu Ala Val
  65                  70                  75                  80

 ttc tgc cat tca ggt cat agc ctg cag tgc tac aac tgt cct aac cca      288
 Phe Cys His Ser Gly His Ser Leu Gln Cys Tyr Asn Cys Pro Asn Pro
                  85                  90                  95

 act gct gac tgc aaa aca gcc gtc aat tgt tca tct gat ttt gat gcg      336
 Thr Ala Asp Cys Lys Thr Ala Val Asn Cys Ser Ser Asp Phe Asp Ala
             100                 105                 110

 tgt ctc att acc aaa gct ggg tta caa gtg tat aac aag tgt tgg aag      384
 Cys Leu Ile Thr Lys Ala Gly Leu Gln Val Tyr Asn Lys Cys Trp Lys
         115                 120                 125

 ttt gag cat tgc aat ttc aac gac gtc aca acc cgc ttg agg gaa aat      432
 Phe Glu His Cys Asn Phe Asn Asp Val Thr Thr Arg Leu Arg Glu Asn
     130                 135                 140

 gag cta acg tac tac tgc tgc aag aag gac ctg tgt aac ttt aac gaa      480
 Glu Leu Thr Tyr Tyr Cys Cys Lys Lys Asp Leu Cys Asn Phe Asn Glu
 145                 150                 155                 160

 cag ctt gaa aat ggt ggg aca tcc tta tca gag aaa aca gtt ctt ctg      528
 Gln Leu Glu Asn Gly Gly Thr Ser Leu Ser Glu Lys Thr Val Leu Leu
                 165                 170                 175

 ctg gtg act cca ttt ctg gca gca gcc tgg agc ctt cat ccc taa          573
 Leu Val Thr Pro Phe Leu Ala Ala Ala Trp Ser Leu His Pro 
             180                 185                 190





      <210> 133
      <211> 2067
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (464)..(2020)

      <400> 133
 atggccctga ccgtggcatc tcacaccttg ggaaagggca cgatagcggt tggcgagagg     60

 ccacatttcc gccacgtgac ccgcgcatgc gcctgcttgc tggagagcga gcgtcttttg    120

 ccacgaacac ctgcggcgtg ccgaagttcc tcttctctgc cccggttccg ggcggtccgc    180

 tgggaggtgg cgcccggagg gacacccgtg cctggggtcg gggccagtgc tcttctcgga    240

 gctccagaag ttctgctgag aagcgcggcg gcagcaagac gacttctccg gagccgccga    300

 gctggagtta gaggtggagc tccgtggggc cgggcccccg gctgcggggc agcggctcct    360

 gcaggcggag gccccggcgg agaatgagcc ggagccggag gtggtggtgg tctcctggca    420

 gagcggtggg accgggagca agctgcggtg gttcaccacc ttg  atg ctg tgt gcc     475
                                                  Met Leu Cys Ala
                                                    1

 tcc ttc ctg ggg ctg gga ttg agt gtt gct ata gtg gga ccc acg ttt      523
 Ser Phe Leu Gly Leu Gly Leu Ser Val Ala Ile Val Gly Pro Thr Phe
   5                  10                  15                  20

 caa gat ttg gca aca aac gtg aac cga aat atc agt agt ctg tct ttc      571
 Gln Asp Leu Ala Thr Asn Val Asn Arg Asn Ile Ser Ser Leu Ser Phe
                  25                  30                  35

 att ttt gtg ggt cgt gcc ttg gga tat ttg agt ggc tct gtg att ggt      619
 Ile Phe Val Gly Arg Ala Leu Gly Tyr Leu Ser Gly Ser Val Ile Gly
              40                  45                  50

 gga ttt ctt gtc gat gtc atg aat tat ttt tta ctt ttg gga atc tca      667
 Gly Phe Leu Val Asp Val Met Asn Tyr Phe Leu Leu Leu Gly Ile Ser
          55                  60                  65

 atg tcg gct acc acc gtt ggt ctt tat ctt gtt cct ttt tgc aag aca      715
 Met Ser Ala Thr Thr Val Gly Leu Tyr Leu Val Pro Phe Cys Lys Thr
      70                  75                  80

 gca ata tta ctc act gtc atg atg tct atc ttc ggt gtt tca att ggc      763
 Ala Ile Leu Leu Thr Val Met Met Ser Ile Phe Gly Val Ser Ile Gly
  85                  90                  95                 100

 att ctg gat aca ggt ggt aac gtc ctt atc ttg gct att tgg ggg gac      811
 Ile Leu Asp Thr Gly Gly Asn Val Leu Ile Leu Ala Ile Trp Gly Asp
                 105                 110                 115

 aaa gga gcc cca cat atg cag gcc tta cac ttc tct ttt gcc ttg ggt      859
 Lys Gly Ala Pro His Met Gln Ala Leu His Phe Ser Phe Ala Leu Gly
             120                 125                 130

 gcc ttt ttg gct cca ctg cta gct aaa ctg gct ttg ggt ccg aca gcg      907
 Ala Phe Leu Ala Pro Leu Leu Ala Lys Leu Ala Leu Gly Pro Thr Ala
         135                 140                 145

 tct gct gaa aac cac aca gag tct gac ttc cat cct gca ctc aac caa      955
 Ser Ala Glu Asn His Thr Glu Ser Asp Phe His Pro Ala Leu Asn Gln
     150                 155                 160

 tca tct gat gct gac tca gaa gct ctg ttt gga gta cct aat gat aag     1003
 Ser Ser Asp Ala Asp Ser Glu Ala Leu Phe Gly Val Pro Asn Asp Lys
 165                 170                 175                 180

 aat tta ctg tgg gct tat gct gtt atc ggt act tac atg ttc tta gtt     1051
 Asn Leu Leu Trp Ala Tyr Ala Val Ile Gly Thr Tyr Met Phe Leu Val
                 185                 190                 195

 tct gtc att ttt ttt tgt ctg ttt tta aag aat agc tca aag caa gaa     1099
 Ser Val Ile Phe Phe Cys Leu Phe Leu Lys Asn Ser Ser Lys Gln Glu
             200                 205                 210

 aaa gca aga gca tct gct gag aca ttt cga aga gca aaa tat cac aac     1147
 Lys Ala Arg Ala Ser Ala Glu Thr Phe Arg Arg Ala Lys Tyr His Asn
         215                 220                 225

 gcc ctt ctt tgt ctc ctt ttt ctg ttc ttc ttt ttt tat gtt gga gct     1195
 Ala Leu Leu Cys Leu Leu Phe Leu Phe Phe Phe Phe Tyr Val Gly Ala
     230                 235                 240

 gag gta aca tat ggc tct tat gtt ttc tca ttt gca acc acc cat gct     1243
 Glu Val Thr Tyr Gly Ser Tyr Val Phe Ser Phe Ala Thr Thr His Ala
 245                 250                 255                 260

 ggc atg aaa gaa agt gaa gct gct ggg ttg aac tcc atc ttc tgg ggg     1291
 Gly Met Lys Glu Ser Glu Ala Ala Gly Leu Asn Ser Ile Phe Trp Gly
                 265                 270                 275

 aca ttt gca gcc tgc agg ggc ctg gca atc ttt ttt gct acc tgt tta     1339
 Thr Phe Ala Ala Cys Arg Gly Leu Ala Ile Phe Phe Ala Thr Cys Leu
             280                 285                 290

 cag cct gga acc atg att gtg ttg agc aac att ggc agc ctg act tca     1387
 Gln Pro Gly Thr Met Ile Val Leu Ser Asn Ile Gly Ser Leu Thr Ser
         295                 300                 305

 tct tta ttt ctg gtg ctt ttt gac aag aac cca att tgt ctc tgg ata     1435
 Ser Leu Phe Leu Val Leu Phe Asp Lys Asn Pro Ile Cys Leu Trp Ile
     310                 315                 320

 gca act tca gtg tat ggg gct tca atg gca acc aca ttt ccg agt ggt     1483
 Ala Thr Ser Val Tyr Gly Ala Ser Met Ala Thr Thr Phe Pro Ser Gly
 325                 330                 335                 340

 gtt tct tgg att gag cag tac acg acc atc cat ggg aaa tct gca gca     1531
 Val Ser Trp Ile Glu Gln Tyr Thr Thr Ile His Gly Lys Ser Ala Ala
                 345                 350                 355

 ttt ttt gta att ggt gct tcc ctg gga gaa atg gct att cct gca gtc     1579
 Phe Phe Val Ile Gly Ala Ser Leu Gly Glu Met Ala Ile Pro Ala Val
             360                 365                 370

 att gga att ctt caa gga aaa tac cct gat ttg cct gta gtt ctg tat     1627
 Ile Gly Ile Leu Gln Gly Lys Tyr Pro Asp Leu Pro Val Val Leu Tyr
         375                 380                 385

 acc tct ttg gga gca tca ata gct act ggt att tta ttt cct gtg cta     1675
 Thr Ser Leu Gly Ala Ser Ile Ala Thr Gly Ile Leu Phe Pro Val Leu
     390                 395                 400

 tat aaa tta gcc act tca cct ctt gat cgc cag cga aaa gaa gac aga     1723
 Tyr Lys Leu Ala Thr Ser Pro Leu Asp Arg Gln Arg Lys Glu Asp Arg
 405                 410                 415                 420

 aag agt gag gac cag aaa gct ctg ctc tct agc tcc ggg cta aat gaa     1771
 Lys Ser Glu Asp Gln Lys Ala Leu Leu Ser Ser Ser Gly Leu Asn Glu
                 425                 430                 435

 tat gag gaa gag aat gaa gag gag gat gca gaa aaa tgg aat gaa atg     1819
 Tyr Glu Glu Glu Asn Glu Glu Glu Asp Ala Glu Lys Trp Asn Glu Met
             440                 445                 450

 gat ttt gaa atg att gaa acg aat gat aca atg agg cat tct ata ata     1867
 Asp Phe Glu Met Ile Glu Thr Asn Asp Thr Met Arg His Ser Ile Ile
         455                 460                 465

 gag aca tct aga agt agt ctg acg gag ccc aca gct gaa gtc tat aat     1915
 Glu Thr Ser Arg Ser Ser Leu Thr Glu Pro Thr Ala Glu Val Tyr Asn
     470                 475                 480

 caa tac cca tca aat gca ctg gtg ttt gag tct tct cct ttt aat act     1963
 Gln Tyr Pro Ser Asn Ala Leu Val Phe Glu Ser Ser Pro Phe Asn Thr
 485                 490                 495                 500

 ggc agt gcc cat gtg aag cac ttg cca gaa acc agg aca aaa ggg act     2011
 Gly Ser Ala His Val Lys His Leu Pro Glu Thr Arg Thr Lys Gly Thr
                 505                 510                 515

 aac gtt tag agaagat ggattactca ctgacatctt tgaataactg ccacttctaa     2067
 Asn Val 






      <210> 134
      <211> 2148
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (1)..(2148)

      <400> 134
  atg gac tgg atc agt ttc tca aca atg gcc tca ctg agc ggg tcc tgt      48
  Met Asp Trp Ile Ser Phe Ser Thr Met Ala Ser Leu Ser Gly Ser Cys
    1               5                  10                  15

 tgg gtc agg tgt ctg ggg cta tgt gac agg ggc tca caa tgg agt cca       96
 Trp Val Arg Cys Leu Gly Leu Cys Asp Arg Gly Ser Gln Trp Ser Pro
              20                  25                  30

 ggg atg tca ggg atg tcc aag tct gtg ctt aga act cat cct ggc ccg      144
 Gly Met Ser Gly Met Ser Lys Ser Val Leu Arg Thr His Pro Gly Pro
          35                  40                  45

 cag agc ctg ccg cga gtc cct ggc gtc ccc tgt ggc ggg ctc ttg gag      192
 Gln Ser Leu Pro Arg Val Pro Gly Val Pro Cys Gly Gly Leu Leu Glu
      50                  55                  60

 cca ctt tcc cga gcg gaa gtc agc ccg cgg ctc gga ctc cgg cgg gac      240
 Pro Leu Ser Arg Ala Glu Val Ser Pro Arg Leu Gly Leu Arg Arg Asp
  65                  70                  75                  80

 ctg ctc gga gga atg gcg ccg ccg ggt tca agc act gtc ttc ctg ttg      288
 Leu Leu Gly Gly Met Ala Pro Pro Gly Ser Ser Thr Val Phe Leu Leu
                  85                  90                  95

 gcc ctg aca atc ata gcc agc acc tgg gct ctg acg ccc act cac tac      336
 Ala Leu Thr Ile Ile Ala Ser Thr Trp Ala Leu Thr Pro Thr His Tyr
             100                 105                 110

 ctc acc aag cat gac gtg gag aga cta aaa gcc tcg ctg gat cgc cct      384
 Leu Thr Lys His Asp Val Glu Arg Leu Lys Ala Ser Leu Asp Arg Pro
         115                 120                 125

 ttc aca aat ttg gaa tct gcc ttc tac tcc atc gtg gga ctc agc agc      432
 Phe Thr Asn Leu Glu Ser Ala Phe Tyr Ser Ile Val Gly Leu Ser Ser
     130                 135                 140

 ctt ggt gct cag gtg cca gat gca aag aaa gca tgt acc tac atc aga      480
 Leu Gly Ala Gln Val Pro Asp Ala Lys Lys Ala Cys Thr Tyr Ile Arg
 145                 150                 155                 160

 tct aac ctt gat ccc agc aat gtg gat tcc ctc ttc tac gct gcc cag      528
 Ser Asn Leu Asp Pro Ser Asn Val Asp Ser Leu Phe Tyr Ala Ala Gln
                 165                 170                 175

 gcc agc cag gcc ctc tca gga tgt gag atc tct att tca aat gag acc      576
 Ala Ser Gln Ala Leu Ser Gly Cys Glu Ile Ser Ile Ser Asn Glu Thr
             180                 185                 190

 aaa gat ctg ctt ctg gca gct gtc agt gag gac tca tct gtt acc cag      624
 Lys Asp Leu Leu Leu Ala Ala Val Ser Glu Asp Ser Ser Val Thr Gln
         195                 200                 205

 atc tac cat gca gtt gca gct cta agt ggc ttt ggc ctt ccc ttg gca      672
 Ile Tyr His Ala Val Ala Ala Leu Ser Gly Phe Gly Leu Pro Leu Ala
     210                 215                 220

 tcc caa gaa gca ctc agt gcc ctt act gct cgt ctc agc aag gag gag      720
 Ser Gln Glu Ala Leu Ser Ala Leu Thr Ala Arg Leu Ser Lys Glu Glu
 225                 230                 235                 240

 act gtg ctg gca aca gtc cag gct ctg cag aca gca tcc cac ctg tcc      768
 Thr Val Leu Ala Thr Val Gln Ala Leu Gln Thr Ala Ser His Leu Ser
                 245                 250                 255

 cag cag gct gac ctg agg agc atc gtg gag gag att gag gac ctt gtt      816
 Gln Gln Ala Asp Leu Arg Ser Ile Val Glu Glu Ile Glu Asp Leu Val
             260                 265                 270

 gct cgc ctg gat gaa ctc ggg ggc gtg tat ctc cag ttt gaa gaa gga      864
 Ala Arg Leu Asp Glu Leu Gly Gly Val Tyr Leu Gln Phe Glu Glu Gly
         275                 280                 285

 ctg gaa aca aca gcg tta ttt gtg gct gcc acc tac aag ctc atg gat      912
 Leu Glu Thr Thr Ala Leu Phe Val Ala Ala Thr Tyr Lys Leu Met Asp
     290                 295                 300

 cat gtg ggg act gag cca tcc att aag gag gat cag gtc atc cag ctg      960
 His Val Gly Thr Glu Pro Ser Ile Lys Glu Asp Gln Val Ile Gln Leu
 305                 310                 315                 320

 atg aac gcg atc ttc agc aag aag aac ttt gag tcc ctc tcc gaa gcc     1008
 Met Asn Ala Ile Phe Ser Lys Lys Asn Phe Glu Ser Leu Ser Glu Ala
                 325                 330                 335

 ttc agc gtg gcc tct gca gct gct gtg ctc tcg cat aat cgc tac cac     1056
 Phe Ser Val Ala Ser Ala Ala Ala Val Leu Ser His Asn Arg Tyr His
             340                 345                 350

 gtg cca gtt gtg gtt gtg cct gag ggc tct gct tcc gac act cat gaa     1104
 Val Pro Val Val Val Val Pro Glu Gly Ser Ala Ser Asp Thr His Glu
         355                 360                 365

 cag gct atc ttg cgg ttg caa gtc acc aat gtt ctg tct cag cct ctg     1152
 Gln Ala Ile Leu Arg Leu Gln Val Thr Asn Val Leu Ser Gln Pro Leu
     370                 375                 380

 act cag gcc act gtt aaa cta gaa cat gct aaa tct gtt gct tcc aga     1200
 Thr Gln Ala Thr Val Lys Leu Glu His Ala Lys Ser Val Ala Ser Arg
 385                 390                 395                 400

 gcc act gtc ctc cag aag aca tcc ttc acc cct gta ggg gat gtt ttt     1248
 Ala Thr Val Leu Gln Lys Thr Ser Phe Thr Pro Val Gly Asp Val Phe
                 405                 410                 415

 gaa cta aat ttc atg aac gtc aaa ttt tcc agt ggt tat tat gac ttc     1296
 Glu Leu Asn Phe Met Asn Val Lys Phe Ser Ser Gly Tyr Tyr Asp Phe
             420                 425                 430

 ctt gtc gaa gtt gaa ggt gac aac cgg tat att gca aat acc gta gag     1344
 Leu Val Glu Val Glu Gly Asp Asn Arg Tyr Ile Ala Asn Thr Val Glu
         435                 440                 445

 ctc aga gtc aag atc tcc act gaa gtt ggc atc aca aat gtt gat ctt     1392
 Leu Arg Val Lys Ile Ser Thr Glu Val Gly Ile Thr Asn Val Asp Leu
     450                 455                 460

 tcc acc gtg gat aag gat cag agc att gca ccc aaa act acc cgg gtg     1440
 Ser Thr Val Asp Lys Asp Gln Ser Ile Ala Pro Lys Thr Thr Arg Val
 465                 470                 475                 480

 aca tac cca gcc aaa gcc aag ggc aca ttc atc gca gac agc cac cag     1488
 Thr Tyr Pro Ala Lys Ala Lys Gly Thr Phe Ile Ala Asp Ser His Gln
                 485                 490                 495

 aac ttc gcc ttg ttc ttc cag ctg gta gat gtg aac act ggt gct gaa     1536
 Asn Phe Ala Leu Phe Phe Gln Leu Val Asp Val Asn Thr Gly Ala Glu
             500                 505                 510

 ctc act cct cac cag aca ttt gtc cga ctc cat aac cag aag act ggc     1584
 Leu Thr Pro His Gln Thr Phe Val Arg Leu His Asn Gln Lys Thr Gly
         515                 520                 525

 cag gaa gtg gtg ttt gtt gcc gag cca gac aac aag aac gtg tac aag     1632
 Gln Glu Val Val Phe Val Ala Glu Pro Asp Asn Lys Asn Val Tyr Lys
     530                 535                 540

 ttt gaa ctg gat acc tct gaa aga aag att gaa ttt gac tct gcc tct     1680
 Phe Glu Leu Asp Thr Ser Glu Arg Lys Ile Glu Phe Asp Ser Ala Ser
 545                 550                 555                 560

 ggc acc tac act ctc tac tta atc att gga gat gcc act ttg aag aac     1728
 Gly Thr Tyr Thr Leu Tyr Leu Ile Ile Gly Asp Ala Thr Leu Lys Asn
                 565                 570                 575

 cca atc ctc tgg aat gtg gct gat gtg gtc atc aag ttc cct gag gaa     1776
 Pro Ile Leu Trp Asn Val Ala Asp Val Val Ile Lys Phe Pro Glu Glu
             580                 585                 590

 gaa gct ccc tcg act gtc ttg tcc cag aac ctt ttc act cca aaa cag     1824
 Glu Ala Pro Ser Thr Val Leu Ser Gln Asn Leu Phe Thr Pro Lys Gln
         595                 600                 605

 gaa att cag cac ctg ttc cgc gag cct gag aag agg ccc ccc acc gtg     1872
 Glu Ile Gln His Leu Phe Arg Glu Pro Glu Lys Arg Pro Pro Thr Val
     610                 615                 620

 gtg tcc aat aca ttc act gcc ctg atc ctc tcg ccg ttg ctt ctg ctc     1920
 Val Ser Asn Thr Phe Thr Ala Leu Ile Leu Ser Pro Leu Leu Leu Leu
 625                 630                 635                 640

 ttc gct ctg tgg atc cgg att ggt gcc aat gtc tcc aac ttc act ttt     1968
 Phe Ala Leu Trp Ile Arg Ile Gly Ala Asn Val Ser Asn Phe Thr Phe
                 645                 650                 655

 gct cct agc acg att ata ttt cac ctg gga cat gct gct atg ctg gga     2016
 Ala Pro Ser Thr Ile Ile Phe His Leu Gly His Ala Ala Met Leu Gly
             660                 665                 670

 ctc atg tat gtc tac tgg act cag ctc aac atg ttc cag acc ttg aag     2064
 Leu Met Tyr Val Tyr Trp Thr Gln Leu Asn Met Phe Gln Thr Leu Lys
         675                 680                 685

 tac ctg gcc atc ttg ggc agt gtg acg ttt ctg gct ggc aat cgg atg     2112
 Tyr Leu Ala Ile Leu Gly Ser Val Thr Phe Leu Ala Gly Asn Arg Met
     690                 695                 700

 ctg gcc cag cag gca gtc aag aga aca gca cat tag                     2148
 Leu Ala Gln Gln Ala Val Lys Arg Thr Ala His 
 705                 710                 715





      <210> 135
      <211> 556
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (28)..(555)

      <400> 135
 gcctgcagga ttcggcacga gggccgg    atg ggg aag gcg gcg gcg gcg gtg      51
                                  Met Gly Lys Ala Ala Ala Ala Val
                                    1               5

 gcc ttt ggg gcc gaa gtg ggc gtg cgg ctc gcg ctg ttc gcg gcc ttc       99
 Ala Phe Gly Ala Glu Val Gly Val Arg Leu Ala Leu Phe Ala Ala Phe
      10                  15                  20

 ctg gtg acg gag ctg ctc ccc ccg ttc cag aga ctc atc cag ccg gag      147
 Leu Val Thr Glu Leu Leu Pro Pro Phe Gln Arg Leu Ile Gln Pro Glu
  25                  30                  35                  40

 gag atg tgg ctc tac cgg aac ccc tac gtg gag gcg gag tat ttc ccc      195
 Glu Met Trp Leu Tyr Arg Asn Pro Tyr Val Glu Ala Glu Tyr Phe Pro
                  45                  50                  55

 acc aag ccg atg ttt gtt att gca ttt ctc tct cca ctg tct ctg atc      243
 Thr Lys Pro Met Phe Val Ile Ala Phe Leu Ser Pro Leu Ser Leu Ile
              60                  65                  70

 ttc ctg gcc aaa ttt ctc aag aag gca gac aca aga gac agc aga caa      291
 Phe Leu Ala Lys Phe Leu Lys Lys Ala Asp Thr Arg Asp Ser Arg Gln
          75                  80                  85

 gcc tgc ctg gct gcc agc ctt gcc ctg gct ctg aat ggc gtc ttt acc      339
 Ala Cys Leu Ala Ala Ser Leu Ala Leu Ala Leu Asn Gly Val Phe Thr
      90                  95                 100

 aac aca ata aaa ctg atc gta ggg agg cca cgc cca gat ttc ttc tac      387
 Asn Thr Ile Lys Leu Ile Val Gly Arg Pro Arg Pro Asp Phe Phe Tyr
 105                 110                 115                 120

 cgc tgc ttc cct gat ggg cta gcc cat tct gac ttg atg tgt aca ggg      435
 Arg Cys Phe Pro Asp Gly Leu Ala His Ser Asp Leu Met Cys Thr Gly
                 125                 130                 135

 gat aag gac gtg gtg aat gag ggc cga aag agc ttc ccc agt gga cat      483
 Asp Lys Asp Val Val Asn Glu Gly Arg Lys Ser Phe Pro Ser Gly His
             140                 145                 150

 tct tcc tgt atg aat atc cat atg ggc tct acc cta tgc ttt ggt ttc      531
 Ser Ser Cys Met Asn Ile His Met Gly Ser Thr Leu Cys Phe Gly Phe
         155                 160                 165

 act tca gtg agt ttg gcc ttg taa g                                    556
 Thr Ser Val Ser Leu Ala Leu 
     170                 175





      <210> 136
      <211> 1642
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (24)..(1121)

      <400> 136
 gagattctcc ccagacgccg agg    atg gcc gtc atg gcg ccc cga acc ctc      50
                              Met Ala Val Met Ala Pro Arg Thr Leu
                                1               5

 ctc ctg ctg ctc tcg ggg gcc ctg gcc ctg acc gag acc tgg gcg ggc       98
 Leu Leu Leu Leu Ser Gly Ala Leu Ala Leu Thr Glu Thr Trp Ala Gly
  10                  15                  20                  25

 tcc cac tcc atg agg tat ttc tac aca tcc gtg tcc cgg ccc ggc cgc      146
 Ser His Ser Met Arg Tyr Phe Tyr Thr Ser Val Ser Arg Pro Gly Arg
                  30                  35                  40

 ggg gag ccc cgc ttc atc gca gtg ggc tac gtg gac gac acg cag ttc      194
 Gly Glu Pro Arg Phe Ile Ala Val Gly Tyr Val Asp Asp Thr Gln Phe
              45                  50                  55

 gtg cgg ttc gac agc gac gcc gcg agc cag agg atg gag ccg cgg gcg      242
 Val Arg Phe Asp Ser Asp Ala Ala Ser Gln Arg Met Glu Pro Arg Ala
          60                  65                  70

 ccg tgg ata gag cag gag ggg ccg gag tat tgg gac cag gag aca cgg      290
 Pro Trp Ile Glu Gln Glu Gly Pro Glu Tyr Trp Asp Gln Glu Thr Arg
      75                  80                  85

 aat gtg aag gcc cac tca cag act gac cga gtg gac ctg ggg acc ctg      338
 Asn Val Lys Ala His Ser Gln Thr Asp Arg Val Asp Leu Gly Thr Leu
  90                  95                 100                 105

 cgc ggc tac tac aac cag agc gag gcc ggt tct cac acc atc cag agg      386
 Arg Gly Tyr Tyr Asn Gln Ser Glu Ala Gly Ser His Thr Ile Gln Arg
                 110                 115                 120

 atg tat ggc tgc gac gtg ggg tcg gac ggg cgc ttc ctc cgc ggg tac      434
 Met Tyr Gly Cys Asp Val Gly Ser Asp Gly Arg Phe Leu Arg Gly Tyr
             125                 130                 135

 cac cag tac gcc tac gac ggc aag gat tac atc gcc ctg aac gag gac      482
 His Gln Tyr Ala Tyr Asp Gly Lys Asp Tyr Ile Ala Leu Asn Glu Asp
         140                 145                 150

 ctg cgc tct tgg acc gcg gcg gac atg gcg gct cag atc acc aag cgc      530
 Leu Arg Ser Trp Thr Ala Ala Asp Met Ala Ala Gln Ile Thr Lys Arg
     155                 160                 165

 aag tgg gag gcg gcc cat gtg gcg gag cag ctg aga gcc tac ctg gag      578
 Lys Trp Glu Ala Ala His Val Ala Glu Gln Leu Arg Ala Tyr Leu Glu
 170                 175                 180                 185

 ggc acg tgc gtg gag tgg ctc cgc aga tac ctg gag aac ggg aag gag      626
 Gly Thr Cys Val Glu Trp Leu Arg Arg Tyr Leu Glu Asn Gly Lys Glu
                 190                 195                 200

 acg ctg cag cgc acg gac ccc ccc aag aca cat atg acc cac cac ccc      674
 Thr Leu Gln Arg Thr Asp Pro Pro Lys Thr His Met Thr His His Pro
             205                 210                 215

 atc tcc aac tat gag gcc acg ctg agg tgc tgg gcc ctg ggc ttc tac      722
 Ile Ser Asn Tyr Glu Ala Thr Leu Arg Cys Trp Ala Leu Gly Phe Tyr
         220                 225                 230

 cct ctg gag atc aca ctg acc cag gag cgg gat ggg gag gac caa att      770
 Pro Leu Glu Ile Thr Leu Thr Gln Glu Arg Asp Gly Glu Asp Gln Ile
     235                 240                 245

 cag gat gca gag ttt gtg gag acc aga ctt gca ggg tac aga acc ttc      818
 Gln Asp Ala Glu Phe Val Glu Thr Arg Leu Ala Gly Tyr Arg Thr Phe
 250                 255                 260                 265

 cag aag tgg gca gct gca gtg gtg tct tct gga gag aag cag agg tac      866
 Gln Lys Trp Ala Ala Ala Val Val Ser Ser Gly Glu Lys Gln Arg Tyr
                 270                 275                 280

 aca tgc cat gtg cag cat gag ggg ttg cct gag ccc ctc aca cta aga      914
 Thr Cys His Val Gln His Glu Gly Leu Pro Glu Pro Leu Thr Leu Arg
             285                 290                 295

 tgg gag ctg tct tcc cag ccc acc atc ccc atc gtg ggc atc att gct      962
 Trp Glu Leu Ser Ser Gln Pro Thr Ile Pro Ile Val Gly Ile Ile Ala
         300                 305                 310

 ggc ctg gtt ctc ttt gga gct gtg atc act gga gct gtg gtc gct gct     1010
 Gly Leu Val Leu Phe Gly Ala Val Ile Thr Gly Ala Val Val Ala Ala
     315                 320                 325

 gtg atg tgg agg agg aag agc tca gat aga aaa gga ggg agc tac tct     1058
 Val Met Trp Arg Arg Lys Ser Ser Asp Arg Lys Gly Gly Ser Tyr Ser
 330                 335                 340                 345

 cag gct gca agc agt gac agt gcc cag ggc tct gat gtg tct ctc aca     1106
 Gln Ala Ala Ser Ser Asp Ser Ala Gln Gly Ser Asp Val Ser Leu Thr
                 350                 355                 360

 gct tgt aaa gtg tga gacagctgcc ttgtgtggga ctgagaggca agagttgttc     1161
 Ala Cys Lys Val 
             365

 ctgcccttcc ctttgtgact tgaagaaccc tgactttgtt tctgcaaagg cacctgcatg   1221

 tgtctgtgtt catgtaggca taatgtgagg aggtggggag accaccccac ccccatgtcc   1281

 accatgaccc tcttcccacg ctgacctgtg ctccctcccc aatcatcttt cctgttgcag   1341

 agaggtgggg ctgaggtgtc tccatctctg tctcaacttc atggtgcact gagctgtaac   1401

 ttcttccttc cctattaaaa ttagaacctg agtataaatt tactttctca aattcttgcc   1461

 atgagaggtt gatgagttaa ttaaaggaga agattcctaa aatttgagag acaaaataaa   1521

 tggaacacat gagaaaaaaa aaaaaatggg gcgccctttt aaacggaacc tttaagggac   1581

 ctattcttac ctgtgactgg aaggcatatg tcctctctta tagacattct aaatagaacc   1641

 a                                                                   1642




      <210> 137
      <211> 1570
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (929)..(1363)

      <400> 137
 ggaaaagtca gcctctcctg catgagtggg agctgcaacc ttttagaatt gataatcaca     60

 aacccctcag acccaaagtg gaataaagaa aaatatgtaa cattaggcat tgatggaaaa    120

 ggactagatc ctagtgtaag catcctaata aaaggagagg ttcaaaaacg ttctccagaa    180

 ccagtatttc agactttcta tgatgaacta aatgtgccag tacctgagat tccaggaaaa    240

 actaaaaatt tgtttttgca attagccaaa catgtagccc agtctctaca agtcgcctat    300

 gtcatgtttg tggaggaacc gtaacaggag atcaatggcc atgggaagcc cgagaattgg    360

 ttcctataga cccggttcct gatgaattcc cagcccaaaa gaaccaccct gacaaatttt    420

 gggttctgaa agtcttatta ttggacagta ttgcatagct agagaaggaa aaggatttac    480

 tcatcctgta gggcagctta gttgtcttgg gcaaaagctg tataatggta ccacaaaaac    540

 agttacatgg tggagttcca attacacaga aaaaaatcca ttcagtaaat ttccaaagtt    600

 gcagactgtt tgggcccacc cagaattgca ctgggactgg acggccccca ctgggttata    660

 ctgggtatgt ggacacagag cttatgctaa gctgcctgat cagtggacag gtagctgtgt    720

 aattggcacc attaagccat ctttcttctt agtgcccata aaaacaggta aacttctggg    780

 cttcccagtc tgtgcttcct gtgaaaaatg aagcatagcc ataggtgatt ggaaagacga    840

 tgaatggccc cctgaaaaaa tcttacaata ctatggacct gccacttggt cacaagatgt    900

 ctcatgggga tatggaaccc ccatctac   atg ctc aac cga atc ata tgg tta     952
                                  Met Leu Asn Arg Ile Ile Trp Leu
                                    1               5

 caa gct gtt tta gaa att att act aat aaa acc act caa gcc ttg act     1000
 Gln Ala Val Leu Glu Ile Ile Thr Asn Lys Thr Thr Gln Ala Leu Thr
      10                  15                  20

 gtt ctt gcc tgg caa gag act atg atg aga aat gct atc tat caa aat     1048
 Val Leu Ala Trp Gln Glu Thr Met Met Arg Asn Ala Ile Tyr Gln Asn
  25                  30                  35                  40

 aga cta gct ctt gat tac ttg cta gca gct gaa gga gga gtt tgt gaa     1096
 Arg Leu Ala Leu Asp Tyr Leu Leu Ala Ala Glu Gly Gly Val Cys Glu
                  45                  50                  55

 aaa ttt gac ctt act aat tat tgt cta cac ata gat gat cag ggg caa     1144
 Lys Phe Asp Leu Thr Asn Tyr Cys Leu His Ile Asp Asp Gln Gly Gln
              60                  65                  70

 gta gtt gag gat ata gtt aaa gat ata aca aaa ctg gca cat gca cct     1192
 Val Val Glu Asp Ile Val Lys Asp Ile Thr Lys Leu Ala His Ala Pro
          75                  80                  85

 gtg caa gtg tgg cac gga ctc aat ctg gga gcc atg ttt gga aat tgg     1240
 Val Gln Val Trp His Gly Leu Asn Leu Gly Ala Met Phe Gly Asn Trp
      90                  95                 100

 ttc cca gca ata ggt gga ttt aaa act ctt ata ata aga gta ata ata     1288
 Phe Pro Ala Ile Gly Gly Phe Lys Thr Leu Ile Ile Arg Val Ile Ile
 105                 110                 115                 120

 gta ata gga acc tgc tta ctg ctc cct tgt ctg ata cct gta ttt ctc     1336
 Val Ile Gly Thr Cys Leu Leu Leu Pro Cys Leu Ile Pro Val Phe Leu
                 125                 130                 135

 caa atg ata aaa aac ttc gtc gct taa cctta gttcaccaaa atgcttcagc     1388
 Gln Met Ile Lys Asn Phe Val Ala 
             140

 acaagcatac tatataaatc actatcaatc tattgcacga aaatacataa gtagcaaaaa   1448

 taagagtgag aactcccact gataaaaagt gagagtctca aagaggggaa atgagggaag   1508

 agagagaccc tctcatattg ttttatattg ttttatactc agtacctctt ttaagaaaaa   1568

 tg                                                                  1570




      <210> 138
      <211> 892
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (6)..(884)

      <400> 138
 ggaac    atg gag cgg ggg ccg gtg gtg ggg gca gga ctg ggg gcc ggg      47
          Met Glu Arg Gly Pro Val Val Gly Ala Gly Leu Gly Ala Gly
            1               5                  10

 gcc cga atc cag gca ctg ctg ggc tgc ctg ctc aag gtg ctg ctc tgg       95
 Ala Arg Ile Gln Ala Leu Leu Gly Cys Leu Leu Lys Val Leu Leu Trp
  15                  20                  25                  30

 gtg gcc tct gcc ttg ctg tac ttt gga agc gaa cag gcc gcc cgc ctt      143
 Val Ala Ser Ala Leu Leu Tyr Phe Gly Ser Glu Gln Ala Ala Arg Leu
                  35                  40                  45

 ctg ggc agc ccc tgc tta cgg cgc ctc tac cat gcc tgg ctg gca gca      191
 Leu Gly Ser Pro Cys Leu Arg Arg Leu Tyr His Ala Trp Leu Ala Ala
              50                  55                  60

 gtg gtc atc ttt ggg ccg ctt ctg cag ttc cat gtc aac cct cgg act      239
 Val Val Ile Phe Gly Pro Leu Leu Gln Phe His Val Asn Pro Arg Thr
          65                  70                  75

 atc ttc gcc agc cac ggc aac ttc ttc aac ata aaa ttt gtg aat tca      287
 Ile Phe Ala Ser His Gly Asn Phe Phe Asn Ile Lys Phe Val Asn Ser
      80                  85                  90

 gcc tgg ggc tgg aca tgc act ttc tta ggg ggc ttt gtg ttg ctg gtg      335
 Ala Trp Gly Trp Thr Cys Thr Phe Leu Gly Gly Phe Val Leu Leu Val
  95                 100                 105                 110

 gtg ttc ctg gct aca cgg cgc gtg gca gta act gcc aga cac ctg agc      383
 Val Phe Leu Ala Thr Arg Arg Val Ala Val Thr Ala Arg His Leu Ser
                 115                 120                 125

 cga ctg gta gta ggg gca gcc gtg tgg cgg gga gcc ggc cgg gcc ttc      431
 Arg Leu Val Val Gly Ala Ala Val Trp Arg Gly Ala Gly Arg Ala Phe
             130                 135                 140

 ctg ctc atc gag gac ctg act ggc tcc tgc ttc gag cca ctg ccc cag      479
 Leu Leu Ile Glu Asp Leu Thr Gly Ser Cys Phe Glu Pro Leu Pro Gln
         145                 150                 155

 ggt ctg ctg ctc cac gag ctg cct gac cgc cgc agc tgc ctg gca gcc      527
 Gly Leu Leu Leu His Glu Leu Pro Asp Arg Arg Ser Cys Leu Ala Ala
     160                 165                 170

 ggc cac cag tgg cga ggc tac acc gtc tcc tcc cac acc ttc ctg ctc      575
 Gly His Gln Trp Arg Gly Tyr Thr Val Ser Ser His Thr Phe Leu Leu
 175                 180                 185                 190

 acc ttt tgc tgc ctg ctc atg gca gag gaa gca gct gtg ttc gcc aag      623
 Thr Phe Cys Cys Leu Leu Met Ala Glu Glu Ala Ala Val Phe Ala Lys
                 195                 200                 205

 tac ctg gcc cat ggg ctt cct gcc ggc gcc cca ctg cgc ctt gtc ttc      671
 Tyr Leu Ala His Gly Leu Pro Ala Gly Ala Pro Leu Arg Leu Val Phe
             210                 215                 220

 ctg ctg aac gtg ctg ctg ctg ggc ctc tgg aac ttc ttg ctg ctc tgt      719
 Leu Leu Asn Val Leu Leu Leu Gly Leu Trp Asn Phe Leu Leu Leu Cys
         225                 230                 235

 acc gtc atc tat ttc cac cag tac act cac aag gtg gtg ggc gcc gca      767
 Thr Val Ile Tyr Phe His Gln Tyr Thr His Lys Val Val Gly Ala Ala
     240                 245                 250

 gtg ggc acc ttt gcc tgg tac ctc acc tat ggc agc tgg tat cat cag      815
 Val Gly Thr Phe Ala Trp Tyr Leu Thr Tyr Gly Ser Trp Tyr His Gln
 255                 260                 265                 270

 ccc tgg tct cca ggg agc cca ggc cat ggg ctc ttc ccc cgt ccc cac      863
 Pro Trp Ser Pro Gly Ser Pro Gly His Gly Leu Phe Pro Arg Pro His
                 275                 280                 285

 tcc agc cgc aag cat aac tga aagaaata                                 892
 Ser Ser Arg Lys His Asn 
             290





      <210> 139
      <211> 1500
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (664)..(1413)

      <400> 139
 agaccccagg cccggacctg cctcgtagtt atattaaaag tctagggatt aaccagcttg     60

 tgcccgtcaa ttggcttcaa ttaatcggca actatactag gaggctttag atcagttcca    120

 cacccagggt ctcgggaatt ccacagtgag aaccaaaagt gctcaggagt taagagaacc    180

 agacgtccga aattatctcc atgcattacc aaaaccccgt ggccaccacc ggcacgggga    240

 aaacttacca ggtacaatga gccagtgact gttactgaat ttcttaagat tacacttttc    300

 ccaactactg cagactgctt cagaatagaa gaaggaggcg ctgttctaca ggatggagag    360

 tggggagctt ggaggagaga gcacgacccc ctgctgctgc cgcaggatgt tgcccttgat    420

 tctaggcaga gacaggaggc atcagacagc tgtgacagcc atggagcttc cctaccactt    480

 ctgagccaga gggaagactt tggagaagca gaagcccaaa gacactgctg ggagattggt    540

 ctgtgctctg ggagaaccct aggttgtgtt tcccgtgtac aagccaccga tcttgtggaa    600

 gtcggctact ttcagtggca gaagaggcca catctgcttc ctgtaggccc tctgggcaga    660

 agc  atg cgc tgg tgt ctc ctc ctg atc tgg gcc cag ggg ctg agg cag     708
      Met Arg Trp Cys Leu Leu Leu Ile Trp Ala Gln Gly Leu Arg Gln
        1               5                  10                  15

 gct ccc ctc gcc tca gga atg atg aca ggc aca ata gaa aca acg ggg      756
 Ala Pro Leu Ala Ser Gly Met Met Thr Gly Thr Ile Glu Thr Thr Gly
                  20                  25                  30

 aac att tct gca gag aaa ggt ggc tct atc atc tta caa tgt cac ctc      804
 Asn Ile Ser Ala Glu Lys Gly Gly Ser Ile Ile Leu Gln Cys His Leu
              35                  40                  45

 tcc tcc acc acg gca caa gtg acc cag gtc aac tgg gag cag cag gac      852
 Ser Ser Thr Thr Ala Gln Val Thr Gln Val Asn Trp Glu Gln Gln Asp
          50                  55                  60

 cag ctt ctg gcc att tgt aat gct gac ttg ggg tgg cac atc tcc cca      900
 Gln Leu Leu Ala Ile Cys Asn Ala Asp Leu Gly Trp His Ile Ser Pro
      65                  70                  75

 tcc ttc aag gat cga gtg gcc cca ggt ccc ggc ctg ggc ctc acc ctc      948
 Ser Phe Lys Asp Arg Val Ala Pro Gly Pro Gly Leu Gly Leu Thr Leu
  80                  85                  90                  95

 cag tcg ctg acc gtg aac gat aca ggg gag tac ttc tgc atc tat cac      996
 Gln Ser Leu Thr Val Asn Asp Thr Gly Glu Tyr Phe Cys Ile Tyr His
                 100                 105                 110

 acc tac cct gat ggg acg tac act ggg aga atc ttc ctg gag gtc cta     1044
 Thr Tyr Pro Asp Gly Thr Tyr Thr Gly Arg Ile Phe Leu Glu Val Leu
             115                 120                 125

 gaa agc tca ggt att cct gct gga gca atg gct gag cac ggt gcc agg     1092
 Glu Ser Ser Gly Ile Pro Ala Gly Ala Met Ala Glu His Gly Ala Arg
         130                 135                 140

 ttc cag att cca ttg ctt gga gcc atg gcc gcg acg ctg gtg gtc atc     1140
 Phe Gln Ile Pro Leu Leu Gly Ala Met Ala Ala Thr Leu Val Val Ile
     145                 150                 155

 tgc aca gca gtc atc gtg gtg gtc gcg ttg act aga aag aaa gcc ctc     1188
 Cys Thr Ala Val Ile Val Val Val Ala Leu Thr Arg Lys Lys Ala Leu
 160                 165                 170                 175

 aga atc cat tct gtg gaa ggt gac ctc agg aga aaa tca gct gga cag     1236
 Arg Ile His Ser Val Glu Gly Asp Leu Arg Arg Lys Ser Ala Gly Gln
                 180                 185                 190

 gag gaa tgg agc ccc agt gct ccc tca ccc cca gga agc tgt gtc cag     1284
 Glu Glu Trp Ser Pro Ser Ala Pro Ser Pro Pro Gly Ser Cys Val Gln
             195                 200                 205

 gca gaa gct gca cct gct ggg ctc tgt gga gag cag cgg gga gag gac     1332
 Ala Glu Ala Ala Pro Ala Gly Leu Cys Gly Glu Gln Arg Gly Glu Asp
         210                 215                 220

 tgt gcc gag ctg cat gac tac ttc aat gtc ctg agt tac aga agc ctg     1380
 Cys Ala Glu Leu His Asp Tyr Phe Asn Val Leu Ser Tyr Arg Ser Leu
     225                 230                 235

 ggt aac tgc agc ttc ttc aca gag act ggt tag caaccaga ggcatcttct     1431
 Gly Asn Cys Ser Phe Phe Thr Glu Thr Gly 
 240                 245

 ggaagataca cttttgtctt tgcaattata gatgaatata taagcagctg tactctccat   1491

 cagtgctgc                                                           1500




      <210> 140
      <211> 741
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (1)..(741)

      <400> 140
  atg gcc cgg ctg ggc gcg ctg ctc ctg gcc gcc gcc ctg ggt gca ctg      48
  Met Ala Arg Leu Gly Ala Leu Leu Leu Ala Ala Ala Leu Gly Ala Leu
    1               5                  10                  15

 ctc agc ttc gcg ctc ctg gcc gcc gcg gtc gcc agc gac tac tgg tac       96
 Leu Ser Phe Ala Leu Leu Ala Ala Ala Val Ala Ser Asp Tyr Trp Tyr
              20                  25                  30

 atc ctg gag gtg gcg gac gcc ggc aat ggc agc gcc tgg ccc ggg cgc      144
 Ile Leu Glu Val Ala Asp Ala Gly Asn Gly Ser Ala Trp Pro Gly Arg
          35                  40                  45

 gca gag ctg ctc tcc tcg cac tcg ggg ctc tgg cgc atc tgc ggg cag      192
 Ala Glu Leu Leu Ser Ser His Ser Gly Leu Trp Arg Ile Cys Gly Gln
      50                  55                  60

 aac ggc tgc atc ccg ctg gtc gac cct ttt gcc agt gag agc ctg gac      240
 Asn Gly Cys Ile Pro Leu Val Asp Pro Phe Ala Ser Glu Ser Leu Asp
  65                  70                  75                  80

 gtc tcc acc tcg gtg cag cac ctc atc ttg ctg cac cgt gca gtc att      288
 Val Ser Thr Ser Val Gln His Leu Ile Leu Leu His Arg Ala Val Ile
                  85                  90                  95

 gtg gtc ctg ccc ctg agc ctg gtc ctt ctc gtg tgt ggc tgg atc tgc      336
 Val Val Leu Pro Leu Ser Leu Val Leu Leu Val Cys Gly Trp Ile Cys
             100                 105                 110

 ggc ctg ctc agc tcc ctg gcc cag agc gtg tct ctg ctg ctt ttc acc      384
 Gly Leu Leu Ser Ser Leu Ala Gln Ser Val Ser Leu Leu Leu Phe Thr
         115                 120                 125

 ggc tgc tac ttc ctg ctg ggg agt gtc ctg aca ctg gcg ggg gtc agc      432
 Gly Cys Tyr Phe Leu Leu Gly Ser Val Leu Thr Leu Ala Gly Val Ser
     130                 135                 140

 atc tac atc agc tac tcg cac ctg gcc ttt gcg gag acg gtg cag cag      480
 Ile Tyr Ile Ser Tyr Ser His Leu Ala Phe Ala Glu Thr Val Gln Gln
 145                 150                 155                 160

 tat ggc ccg cag cac atg cag ggc gtc cgc gtc agc ttc ggc tgg tcc      528
 Tyr Gly Pro Gln His Met Gln Gly Val Arg Val Ser Phe Gly Trp Ser
                 165                 170                 175

 atg gcc ctg gcc tgg ggc tcc tgt gcc ttg gag gca ttc agc gga acc      576
 Met Ala Leu Ala Trp Gly Ser Cys Ala Leu Glu Ala Phe Ser Gly Thr
             180                 185                 190

 ctc ctg ctc tca gct gcc tgg acc ctc agc ctg agc ccc cca atc tgt      624
 Leu Leu Leu Ser Ala Ala Trp Thr Leu Ser Leu Ser Pro Pro Ile Cys
         195                 200                 205

 ggt cat ctg agt ccc cag cag gtg gga ggg aga cct tgg atg ttg aaa      672
 Gly His Leu Ser Pro Gln Gln Val Gly Gly Arg Pro Trp Met Leu Lys
     210                 215                 220

 gtg aat aca gtg cac tgt cct cac aac ggg gaa aag gag gag aac ggt      720
 Val Asn Thr Val His Cys Pro His Asn Gly Glu Lys Glu Glu Asn Gly
 225                 230                 235                 240

 atg cgg gat ccc ctg tac tag                                          741
 Met Arg Asp Pro Leu Tyr 
                 245





      <210> 141
      <211> 267
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (1)..(267)

      <400> 141
  atg aaa gcc ctt atg ctg ctc acc ctg tct gtt ctg ctc tgc tgg gtc      48
  Met Lys Ala Leu Met Leu Leu Thr Leu Ser Val Leu Leu Cys Trp Val
    1               5                  10                  15

 tca ggt aag atg tgg gtt ttc tcc aat ctg cgc tgt ggc aca cca gaa       96
 Ser Gly Lys Met Trp Val Phe Ser Asn Leu Arg Cys Gly Thr Pro Glu
              20                  25                  30

 gag ccc tgt cag gag gcc ttc aac caa acc aac cgc aag ctg ggt ctg      144
 Glu Pro Cys Gln Glu Ala Phe Asn Gln Thr Asn Arg Lys Leu Gly Leu
          35                  40                  45

 aca tat aac acc acc tgc tgc aac aag gac aac tgc aac agc gca gga      192
 Thr Tyr Asn Thr Thr Cys Cys Asn Lys Asp Asn Cys Asn Ser Ala Gly
      50                  55                  60

 ccc cgg ccc act cca gcc ctg ggc ctt gtc ttc ctt acc tcc ttg gct      240
 Pro Arg Pro Thr Pro Ala Leu Gly Leu Val Phe Leu Thr Ser Leu Ala
  65                  70                  75                  80

 ggc ctt ggc ctc tgg ctg ctg cac tga                                  267
 Gly Leu Gly Leu Trp Leu Leu His 
                  85





      <210> 142
      <211> 919
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (1)..(828)

      <400> 142
  atg gcg cct cct ccg cct tcg ccc caa ctg ctt ctc ctg gca gcc ctc      48
  Met Ala Pro Pro Pro Pro Ser Pro Gln Leu Leu Leu Leu Ala Ala Leu
    1               5                  10                  15

 gcg agg ctc ctg ggt ccc agc gag gct gag gat gtc acc ttc ctc tac       96
 Ala Arg Leu Leu Gly Pro Ser Glu Ala Glu Asp Val Thr Phe Leu Tyr
              20                  25                  30

 cac ccc tgt gcc cat ccc tgg ctg aag ctc cag ctt gcc ctc ctg gcc      144
 His Pro Cys Ala His Pro Trp Leu Lys Leu Gln Leu Ala Leu Leu Ala
          35                  40                  45

 tat gct tgt atg gct aac cct tcc ctc acc cct gac ttc agc ctc acg      192
 Tyr Ala Cys Met Ala Asn Pro Ser Leu Thr Pro Asp Phe Ser Leu Thr
      50                  55                  60

 cag gat cgg gcc ctg gct ctg gcc ttt gct ctg cgg agc tgg cgg ccc      240
 Gln Asp Arg Ala Leu Ala Leu Ala Phe Ala Leu Arg Ser Trp Arg Pro
  65                  70                  75                  80

 cct ggc aca gag gtg aca tct caa ggg ccc agg cag ccc tct tct agt      288
 Pro Gly Thr Glu Val Thr Ser Gln Gly Pro Arg Gln Pro Ser Ser Ser
                  85                  90                  95

 ggt gcc aag agg cgg agg ctg cgg gct gcc ctt ggt ccc cag cct act      336
 Gly Ala Lys Arg Arg Arg Leu Arg Ala Ala Leu Gly Pro Gln Pro Thr
             100                 105                 110

 cgc tca gcc ctg agg ttt ccc tct gct tcc cca ggg agc ttg aag gcc      384
 Arg Ser Ala Leu Arg Phe Pro Ser Ala Ser Pro Gly Ser Leu Lys Ala
         115                 120                 125

 aag cag tcc atg gcg gga atc cct ggt agg gag agt aat gcc cca tct      432
 Lys Gln Ser Met Ala Gly Ile Pro Gly Arg Glu Ser Asn Ala Pro Ser
     130                 135                 140

 gtg ccc act gtc tcc ctg ctg ccg ggg gcg cct gga ggc aat gcc agc      480
 Val Pro Thr Val Ser Leu Leu Pro Gly Ala Pro Gly Gly Asn Ala Ser
 145                 150                 155                 160

 tcc agg aca gag gct cag gtg ccc aac ggg caa ggc agc cca ggg ggc      528
 Ser Arg Thr Glu Ala Gln Val Pro Asn Gly Gln Gly Ser Pro Gly Gly
                 165                 170                 175

 tgt gtc tgt tca agt cag gct tcc ccg gcc cct cgc gca gca gcg cct      576
 Cys Val Cys Ser Ser Gln Ala Ser Pro Ala Pro Arg Ala Ala Ala Pro
             180                 185                 190

 cca cgg gca gcc cgg ggc ccc acc cca cgc act gaa gag gcc gcc tgg      624
 Pro Arg Ala Ala Arg Gly Pro Thr Pro Arg Thr Glu Glu Ala Ala Trp
         195                 200                 205

 gct gcc atg gcc ctg acc ttc ctg ctg gtg ctg ctc acc ctg gcc acg      672
 Ala Ala Met Ala Leu Thr Phe Leu Leu Val Leu Leu Thr Leu Ala Thr
     210                 215                 220

 ctc tgc aca cgg ctg cac aga aac ttc cga cgc ggg gag agc atc tac      720
 Leu Cys Thr Arg Leu His Arg Asn Phe Arg Arg Gly Glu Ser Ile Tyr
 225                 230                 235                 240

 tgg ggg ccg cga cct ctg cca cgt gga ccg cgc gcg ggg cgc tcc ctg      768
 Trp Gly Pro Arg Pro Leu Pro Arg Gly Pro Arg Ala Gly Arg Ser Leu
                 245                 250                 255

 gtg gcg atg gcg cgg cac tgg ccg agc act gcg ggg gct ttc ctc ctt      816
 Val Ala Met Ala Arg His Trp Pro Ser Thr Ala Gly Ala Phe Leu Leu
             260                 265                 270

 gtt ggt tgc tga gtg ggcggccaag gggagaaaag gagccgcttc tgcctccctt      871
 Val Gly Cys 
         275

 gccaaaactc cgtttctaat taaattattt ttagtagaaa aaaaaaaa                 919




      <210> 143
      <211> 2481
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (1)..(2481)

      <400> 143
  atg gcc cgg gcc agg gcc ggg gcg ctg ctg gcg ctt tgg gtg ctc ggg      48
  Met Ala Arg Ala Arg Ala Gly Ala Leu Leu Ala Leu Trp Val Leu Gly
    1               5                  10                  15

 gcc gcc gcg cat ccg cag tgc ctg gac ttc agg ccg ccc ttc cgg ccg       96
 Ala Ala Ala His Pro Gln Cys Leu Asp Phe Arg Pro Pro Phe Arg Pro
              20                  25                  30

 acg cag ccg ctg cgc ctc tgc gcg cag tac tcg gac ttc ggc tgc tgc      144
 Thr Gln Pro Leu Arg Leu Cys Ala Gln Tyr Ser Asp Phe Gly Cys Cys
          35                  40                  45

 gat gag ggg cgc gac gcc gag ctg acc cgc cgc ttc tgg gcc ctg gcg      192
 Asp Glu Gly Arg Asp Ala Glu Leu Thr Arg Arg Phe Trp Ala Leu Ala
      50                  55                  60

 agc cgc gtg gac gcc gcc gag tgg gcc gcg tgc gcc ggc tac gcg agg      240
 Ser Arg Val Asp Ala Ala Glu Trp Ala Ala Cys Ala Gly Tyr Ala Arg
  65                  70                  75                  80

 gac ctg ctg tgc cag tcc gtg gag tgg aca gac atg caa aga gat aat      288
 Asp Leu Leu Cys Gln Ser Val Glu Trp Thr Asp Met Gln Arg Asp Asn
                  85                  90                  95

 gaa gtc cta gcc aag ctg act ggc tgg agc gcc cct ggc gac gga gca      336
 Glu Val Leu Ala Lys Leu Thr Gly Trp Ser Ala Pro Gly Asp Gly Ala
             100                 105                 110

 gtg act gct gta gag aac tca ccc tct ctg gac tac cct ggt ctg ggc      384
 Val Thr Ala Val Glu Asn Ser Pro Ser Leu Asp Tyr Pro Gly Leu Gly
         115                 120                 125

 acc aca ttt acg tcg tgt gaa tgc tcg ccg tat gca gcc cac ctc tat      432
 Thr Thr Phe Thr Ser Cys Glu Cys Ser Pro Tyr Ala Ala His Leu Tyr
     130                 135                 140

 gac gcc gag gac cca ttc acg ccc ctg cgc acg gtg ccc ggg ctc tgc      480
 Asp Ala Glu Asp Pro Phe Thr Pro Leu Arg Thr Val Pro Gly Leu Cys
 145                 150                 155                 160

 cag gat tac tgc ctg gac atg tgg cat aag tgc cgg ggg ctg ttc cgt      528
 Gln Asp Tyr Cys Leu Asp Met Trp His Lys Cys Arg Gly Leu Phe Arg
                 165                 170                 175

 cac ctg tca act gac cag gag ctc tgg gcg ctg gag ggc aac ctt gcc      576
 His Leu Ser Thr Asp Gln Glu Leu Trp Ala Leu Glu Gly Asn Leu Ala
             180                 185                 190

 agg ttc tgc cgc tac ctg tcc ctg gat gac acg gac tac tgc ttc cct      624
 Arg Phe Cys Arg Tyr Leu Ser Leu Asp Asp Thr Asp Tyr Cys Phe Pro
         195                 200                 205

 tac ctg ctg gtc aac aag aac ctc aac tca aac ctg ggc cac gtg gta      672
 Tyr Leu Leu Val Asn Lys Asn Leu Asn Ser Asn Leu Gly His Val Val
     210                 215                 220

 gcc gat gcc aag ggc tgc ctg cag ctg tgc ctg gag gag gtg gcc aac      720
 Ala Asp Ala Lys Gly Cys Leu Gln Leu Cys Leu Glu Glu Val Ala Asn
 225                 230                 235                 240

 ggg ctg cgc aac ccc gtg gcc atg gtc cat gcc agg gat ggc acc cac      768
 Gly Leu Arg Asn Pro Val Ala Met Val His Ala Arg Asp Gly Thr His
                 245                 250                 255

 cgc ttc ttc gtg gcc gag cag gtg ggg ctg gtg tgg gcc tac ctg ccc      816
 Arg Phe Phe Val Ala Glu Gln Val Gly Leu Val Trp Ala Tyr Leu Pro
             260                 265                 270

 gac cgc tcg agg ctg ggg aag cct ttc ctg aac atc agc cgg gtg gtg      864
 Asp Arg Ser Arg Leu Gly Lys Pro Phe Leu Asn Ile Ser Arg Val Val
         275                 280                 285

 ctc acc tcg ccc tgg gag ggt gac gag cgt ggc ttc ctg ggc att gcc      912
 Leu Thr Ser Pro Trp Glu Gly Asp Glu Arg Gly Phe Leu Gly Ile Ala
     290                 295                 300

 ttc cac ccc agc ttc cag cac aac cgc agg ctc tac gtc tac tac tca      960
 Phe His Pro Ser Phe Gln His Asn Arg Arg Leu Tyr Val Tyr Tyr Ser
 305                 310                 315                 320

 gtg ggt atc cgc agc agt gag tgg atc cgc atc agc gag ttc aga gtc     1008
 Val Gly Ile Arg Ser Ser Glu Trp Ile Arg Ile Ser Glu Phe Arg Val
                 325                 330                 335

 tcc gag gat gac gag aac gcc gtg gac cac agc tct gag agg ata atc     1056
 Ser Glu Asp Asp Glu Asn Ala Val Asp His Ser Ser Glu Arg Ile Ile
             340                 345                 350

 ctg gag gtc aaa gaa cca gcc tca aac cac aac ggg ggc cag ctg ctt     1104
 Leu Glu Val Lys Glu Pro Ala Ser Asn His Asn Gly Gly Gln Leu Leu
         355                 360                 365

 ttc ggg gat gac ggg tac ctc tac atc ttc act gga gat ggc ggg atg     1152
 Phe Gly Asp Asp Gly Tyr Leu Tyr Ile Phe Thr Gly Asp Gly Gly Met
     370                 375                 380

 gcc gga gac ccc ttt ggg aca ttt gga aat gcc caa aac aag tat gtt     1200
 Ala Gly Asp Pro Phe Gly Thr Phe Gly Asn Ala Gln Asn Lys Tyr Val
 385                 390                 395                 400

 cag ctt ttg att ggc ttg tgg gtt ggt ctc cat atc cct ggg ctt ctc     1248
 Gln Leu Leu Ile Gly Leu Trp Val Gly Leu His Ile Pro Gly Leu Leu
                 405                 410                 415

 ata ctc ttc cag agg tcg gcg ctg ctg ggc aag gtg ctg cgc atc gac     1296
 Ile Leu Phe Gln Arg Ser Ala Leu Leu Gly Lys Val Leu Arg Ile Asp
             420                 425                 430

 gtg gac cgt aag gga gcg cgg cct gcc cta cgg cat ccc gcc cga caa     1344
 Val Asp Arg Lys Gly Ala Arg Pro Ala Leu Arg His Pro Ala Arg Gln
         435                 440                 445

 ccc gtt cgt ggg cga ccc cgc ggc gca gcc gag gtc tac gcc cta ggc     1392
 Pro Val Arg Gly Arg Pro Arg Gly Ala Ala Glu Val Tyr Ala Leu Gly
     450                 455                 460

 gtg cgc aac atg tgg cgc tgc tcc ttc gac cgt ggc gac ccc tcc tcg     1440
 Val Arg Asn Met Trp Arg Cys Ser Phe Asp Arg Gly Asp Pro Ser Ser
 465                 470                 475                 480

 ggc act ggc cgc ggg cgc ctc ttc tgc ggc gac gtg ggc cag aac aag     1488
 Gly Thr Gly Arg Gly Arg Leu Phe Cys Gly Asp Val Gly Gln Asn Lys
                 485                 490                 495

 ttc gag gag gtg gac gtg gtg gag cgc ggc ggc aac tat ggc tgg cgc     1536
 Phe Glu Glu Val Asp Val Val Glu Arg Gly Gly Asn Tyr Gly Trp Arg
             500                 505                 510

 gcg cgc gaa ggg ttc gag tgc tac gac cgc agc ctg tgc gcc aac acc     1584
 Ala Arg Glu Gly Phe Glu Cys Tyr Asp Arg Ser Leu Cys Ala Asn Thr
         515                 520                 525

 tct ctc aat gac ttg ctg ccg att ttc gcc tac ccg cac acg gtt ggc     1632
 Ser Leu Asn Asp Leu Leu Pro Ile Phe Ala Tyr Pro His Thr Val Gly
     530                 535                 540

 aag tcg gtc aca ggg ggc tac gtg tac cgg ggc tgc gag tac ccc aac     1680
 Lys Ser Val Thr Gly Gly Tyr Val Tyr Arg Gly Cys Glu Tyr Pro Asn
 545                 550                 555                 560

 ctg aac ggc ctc tac att ttt ggg gat ttc atg agc ggg cgt ctg atg     1728
 Leu Asn Gly Leu Tyr Ile Phe Gly Asp Phe Met Ser Gly Arg Leu Met
                 565                 570                 575

 tcc ctc caa gag aac cca ggg aca ggc cag tgg cag tac agt gag atc     1776
 Ser Leu Gln Glu Asn Pro Gly Thr Gly Gln Trp Gln Tyr Ser Glu Ile
             580                 585                 590

 tgc atg ggc cac ggc cag acc tgt gag ttc cca ggc ctc atc aac aac     1824
 Cys Met Gly His Gly Gln Thr Cys Glu Phe Pro Gly Leu Ile Asn Asn
         595                 600                 605

 tac tac ccg tac atc atc tcc ttc ggg gag gac gag gcc ggg gag ctg     1872
 Tyr Tyr Pro Tyr Ile Ile Ser Phe Gly Glu Asp Glu Ala Gly Glu Leu
     610                 615                 620

 tac ttc atg tcg aca ggg gag ccg agt gcc aca gct cca cgc gga gtt     1920
 Tyr Phe Met Ser Thr Gly Glu Pro Ser Ala Thr Ala Pro Arg Gly Val
 625                 630                 635                 640

 gtc tac aaa ata att gac gca tcc aga gtt cat ccc gaa gac acg gag     1968
 Val Tyr Lys Ile Ile Asp Ala Ser Arg Val His Pro Glu Asp Thr Glu
                 645                 650                 655

 cac ccc gcg gcc tac agc gcg ggc gcc cac gcg ggc gcc cgc cga ggg     2016
 His Pro Ala Ala Tyr Ser Ala Gly Ala His Ala Gly Ala Arg Arg Gly
             660                 665                 670

 cgc ccc acg gcc gct ccc ccc gcg cca acc ccg cgg cca gcg cgg ccc     2064
 Arg Pro Thr Ala Ala Pro Pro Ala Pro Thr Pro Arg Pro Ala Arg Pro
         675                 680                 685

 acc cag cag cca ggg agc cgg agg ggc ggc ggg cgg cgg cgg ggg cgg     2112
 Thr Gln Gln Pro Gly Ser Arg Arg Gly Gly Gly Arg Arg Arg Gly Arg
     690                 695                 700

 ctg aac tcg gcg agc cgg gcg ttc cgg gat ggc gag gtg cgc ctg gtg     2160
 Leu Asn Ser Ala Ser Arg Ala Phe Arg Asp Gly Glu Val Arg Leu Val
 705                 710                 715                 720

 cgg ccc gcg ggc ctg agc tct ggc agc ggg cgc gtg gag gtg ttc gtg     2208
 Arg Pro Ala Gly Leu Ser Ser Gly Ser Gly Arg Val Glu Val Phe Val
                 725                 730                 735

 ggc gga cgc tgg ggc acc gtg tgc gac gac tcc tgg aac atc agc ggc     2256
 Gly Gly Arg Trp Gly Thr Val Cys Asp Asp Ser Trp Asn Ile Ser Gly
             740                 745                 750

 gcc gcc gtc gtg tgt cgc cag ctg ggg ttt gcc tac gcc gtg cgc gcc     2304
 Ala Ala Val Val Cys Arg Gln Leu Gly Phe Ala Tyr Ala Val Arg Ala
         755                 760                 765

 gtc aag aga gcc gag ttc ggc cag ggc ggc tcg ctg ccc att ctg ctg     2352
 Val Lys Arg Ala Glu Phe Gly Gln Gly Gly Ser Leu Pro Ile Leu Leu
     770                 775                 780

 gac gat gtg cgc tgc gcg ggc tgg gag cgg aac ctg ctg gag tgc cag     2400
 Asp Asp Val Arg Cys Ala Gly Trp Glu Arg Asn Leu Leu Glu Cys Gln
 785                 790                 795                 800

 cac aac ggc gtg ggc acc cac aac tgc gag cac gac gag gat gcg ggc     2448
 His Asn Gly Val Gly Thr His Asn Cys Glu His Asp Glu Asp Ala Gly
                 805                 810                 815

 gtc gtg tgc agc cac cag aac ccc gac ctg tag                         2481
 Val Val Cys Ser His Gln Asn Pro Asp Leu 
             820                 825





      <210> 144
      <211> 1269
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (1)..(1269)

      <400> 144
  atg gcg ggc tgc tgc gcc gcg ctg gcg gcc ttc ctg ttc gag tac gac      48
  Met Ala Gly Cys Cys Ala Ala Leu Ala Ala Phe Leu Phe Glu Tyr Asp
    1               5                  10                  15

 acg ccg cgc atc gtg ctc atc cgc agc cgc aaa gtg ggg ctc atg aac       96
 Thr Pro Arg Ile Val Leu Ile Arg Ser Arg Lys Val Gly Leu Met Asn
              20                  25                  30

 cgc gcc gtg caa ctg ctc atc ctg gcc tac gtc atc ggg tgg gtg ttt      144
 Arg Ala Val Gln Leu Leu Ile Leu Ala Tyr Val Ile Gly Trp Val Phe
          35                  40                  45

 gtg tgg gaa aag ggc tac cag gaa act gac tcc gtg gtc agc tcc gtt      192
 Val Trp Glu Lys Gly Tyr Gln Glu Thr Asp Ser Val Val Ser Ser Val
      50                  55                  60

 acg acc aag gtc aag ggc gtg gct gtg acc aac act tct aaa ctt gga      240
 Thr Thr Lys Val Lys Gly Val Ala Val Thr Asn Thr Ser Lys Leu Gly
  65                  70                  75                  80

 ttc cgg atc tgg gat gtg gcg gat tat gtg ata cca gct cag gag gaa      288
 Phe Arg Ile Trp Asp Val Ala Asp Tyr Val Ile Pro Ala Gln Glu Glu
                  85                  90                  95

 aac tcc ctc ttc gtc atg acc aac gtg atc ctc acc atg aac cag aca      336
 Asn Ser Leu Phe Val Met Thr Asn Val Ile Leu Thr Met Asn Gln Thr
             100                 105                 110

 cag ggc ctg tgc ccc gag att cca gat gcg acc act gtg tgt aaa tca      384
 Gln Gly Leu Cys Pro Glu Ile Pro Asp Ala Thr Thr Val Cys Lys Ser
         115                 120                 125

 gat gcc agc tgt act gcc ggc tct gcc ggc acc cac agc aac gga gtc      432
 Asp Ala Ser Cys Thr Ala Gly Ser Ala Gly Thr His Ser Asn Gly Val
     130                 135                 140

 tca aca ggc agg tgc gta gct ttc aac ggg tct gtc aag acg tgt gag      480
 Ser Thr Gly Arg Cys Val Ala Phe Asn Gly Ser Val Lys Thr Cys Glu
 145                 150                 155                 160

 gtg gcg gcc tgg tgc ccg gtg gag gat gac aca cac gtg cca caa cct      528
 Val Ala Ala Trp Cys Pro Val Glu Asp Asp Thr His Val Pro Gln Pro
                 165                 170                 175

 gct ttt tta aag gct gca gaa aac ttc act ctt ttg gtt aag aac aac      576
 Ala Phe Leu Lys Ala Ala Glu Asn Phe Thr Leu Leu Val Lys Asn Asn
             180                 185                 190

 atc tgg tat ccc aaa ttt aat ttc agc aag agg aat atc ctt ccc aac      624
 Ile Trp Tyr Pro Lys Phe Asn Phe Ser Lys Arg Asn Ile Leu Pro Asn
         195                 200                 205

 atc acc act act tac ctc aag tcg tgc att tat gat gct aaa aca gat      672
 Ile Thr Thr Thr Tyr Leu Lys Ser Cys Ile Tyr Asp Ala Lys Thr Asp
     210                 215                 220

 ccc ttc tgc ccc ata ttc cgt ctt ggc aaa ata gtg gag aac gca gga      720
 Pro Phe Cys Pro Ile Phe Arg Leu Gly Lys Ile Val Glu Asn Ala Gly
 225                 230                 235                 240

 cac agt ttc cag gac atg gcc gtg gag gga ggc atc atg ggc atc cag      768
 His Ser Phe Gln Asp Met Ala Val Glu Gly Gly Ile Met Gly Ile Gln
                 245                 250                 255

 gtc aac tgg gac tgc aac ctg gac aga gcc gcc tcc ctc tgc ttg ccc      816
 Val Asn Trp Asp Cys Asn Leu Asp Arg Ala Ala Ser Leu Cys Leu Pro
             260                 265                 270

 agg tac tcc ttc cgc cgc ctc gat aca cgg gac gtt gag cac aac gta      864
 Arg Tyr Ser Phe Arg Arg Leu Asp Thr Arg Asp Val Glu His Asn Val
         275                 280                 285

 tct cct ggc tac aat ttc agg ttt gcc aag tac tac aga gac ctg gct      912
 Ser Pro Gly Tyr Asn Phe Arg Phe Ala Lys Tyr Tyr Arg Asp Leu Ala
     290                 295                 300

 ggc aac gag cag cgc acg ctc atc aag gcc tat ggc atc cgc ttc gac      960
 Gly Asn Glu Gln Arg Thr Leu Ile Lys Ala Tyr Gly Ile Arg Phe Asp
 305                 310                 315                 320

 atc att gtg ttt ggg aag gca ggg aaa ttt gac atc atc ccc act atg     1008
 Ile Ile Val Phe Gly Lys Ala Gly Lys Phe Asp Ile Ile Pro Thr Met
                 325                 330                 335

 atc aac atc ggc tct ggc ctg gca ctg cta ggc atg gcg acc gtg ctg     1056
 Ile Asn Ile Gly Ser Gly Leu Ala Leu Leu Gly Met Ala Thr Val Leu
             340                 345                 350

 tgt gac atc ata gtc ctc tac tgc atg aag aaa aga ctc tac tat cgg     1104
 Cys Asp Ile Ile Val Leu Tyr Cys Met Lys Lys Arg Leu Tyr Tyr Arg
         355                 360                 365

 gag aag aaa tat aaa tat gtg gaa gat tac gag cag gta ggc ccc tcc     1152
 Glu Lys Lys Tyr Lys Tyr Val Glu Asp Tyr Glu Gln Val Gly Pro Ser
     370                 375                 380

 tgg ccc cca gca ggc aca ggc ctc tca tct ctt ggg tgt ggg agc cct     1200
 Trp Pro Pro Ala Gly Thr Gly Leu Ser Ser Leu Gly Cys Gly Ser Pro
 385                 390                 395                 400

 ggg cgt ggg cct gtc tgg gga ggc cct tct gca gag gct ggc acc agt     1248
 Gly Arg Gly Pro Val Trp Gly Gly Pro Ser Ala Glu Ala Gly Thr Ser
                 405                 410                 415

 gtg gcg tgg tgt ccc cgt taa                                         1269
 Val Ala Trp Cys Pro Arg 
             420





      <210> 145
      <211> 1142
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (272)..(1114)

      <400> 145
 gaattcccgg gtcgactatt ctgtcgagaa cattcttacg aggcagtgat taccatgatt     60

 acccggcgct gtcacacgac tcaatatcag aaggtgagcc ctattcacac ctcggccagg    120

 ctgcggtggc caggactggt ttgggaaggc agggccccgg tgtgcagcca cagccagcag    180

 cctcctacct acacaagggt gttcgggagc atctcagggc cgaagacttt gctgcctgcc    240

 ctgccaggac tttgtcctca cccctggcac c   atg cag ctc cag gtg ttc tgg     292
                                      Met Gln Leu Gln Val Phe Trp
                                        1               5

 act ggg ctg gaa tac acc tgc cgg ctc ctg ggc atc acc act gct gca      340
 Thr Gly Leu Glu Tyr Thr Cys Arg Leu Leu Gly Ile Thr Thr Ala Ala
          10                  15                  20

 gtg ttg atc ggc gtg ggc act gag acc ttc ctc cag ggc cag ttc aaa      388
 Val Leu Ile Gly Val Gly Thr Glu Thr Phe Leu Gln Gly Gln Phe Lys
      25                  30                  35

 agc ctg gct ttc tat ctg ctc atg gcc cag tcc gga aca cgc cat gtc      436
 Ser Leu Ala Phe Tyr Leu Leu Met Ala Gln Ser Gly Thr Arg His Val
  40                  45                  50                  55

 ctg gag aca gcc cgt ggt gaa tgt tgt ctg ggg gaa tcc agg ttt aca      484
 Leu Glu Thr Ala Arg Gly Glu Cys Cys Leu Gly Glu Ser Arg Phe Thr
                  60                  65                  70

 gga gcc gct gtc tcc ata tgt gaa ggg gcc tac ttt gtg gct cag ctg      532
 Gly Ala Ala Val Ser Ile Cys Glu Gly Ala Tyr Phe Val Ala Gln Leu
              75                  80                  85

 ctg gcc atc tgc ttc cag tgt caa cca ggg tcc ctg gca gac aga gta      580
 Leu Ala Ile Cys Phe Gln Cys Gln Pro Gly Ser Leu Ala Asp Arg Val
          90                  95                 100

 agg gag aaa gcc cac tgg ctg ggc tgc ttc cag aag ttc ctg gcc tac      628
 Arg Glu Lys Ala His Trp Leu Gly Cys Phe Gln Lys Phe Leu Ala Tyr
     105                 110                 115

 ctg ctg ctg tcg gtg gcc tgc ttc ctc cac ccg gtc ctg gtc tgg cac      676
 Leu Leu Leu Ser Val Ala Cys Phe Leu His Pro Val Leu Val Trp His
 120                 125                 130                 135

 gtg acc atc cca ggc tcc atg ctc atc atc acc ggc ctg gcc tac ttc      724
 Val Thr Ile Pro Gly Ser Met Leu Ile Ile Thr Gly Leu Ala Tyr Phe
                 140                 145                 150

 ctt ctg agc aag cgg aag aag agg aaa gct gcc ccc gag gtg ctg gcc      772
 Leu Leu Ser Lys Arg Lys Lys Arg Lys Ala Ala Pro Glu Val Leu Ala
             155                 160                 165

 tcc cca gag cag tac aca gac ccc tct agc agc gct gtg agc acc acc      820
 Ser Pro Glu Gln Tyr Thr Asp Pro Ser Ser Ser Ala Val Ser Thr Thr
         170                 175                 180

 ggc tct ggg gac aca gag caa acc tac act ttc cat ggg gcc ctc aag      868
 Gly Ser Gly Asp Thr Glu Gln Thr Tyr Thr Phe His Gly Ala Leu Lys
     185                 190                 195

 gag ggg ccc agc tcc ctt ttc atc cac atg aag agt atc ctg aag ggg      916
 Glu Gly Pro Ser Ser Leu Phe Ile His Met Lys Ser Ile Leu Lys Gly
 200                 205                 210                 215

 act aag aag ccc agt gcc ctc cag ccc ccc aac acc ctg atg gag ctg      964
 Thr Lys Lys Pro Ser Ala Leu Gln Pro Pro Asn Thr Leu Met Glu Leu
                 220                 225                 230

 agc ctg gag cca gcc gac tcc ctg gcc aag aag aag cag gtg cac ttt     1012
 Ser Leu Glu Pro Ala Asp Ser Leu Ala Lys Lys Lys Gln Val His Phe
             235                 240                 245

 gaa gac aac ttg gtc cgc ata gtc ccc tcc ctc gcc gaa ggt ctg gat     1060
 Glu Asp Asn Leu Val Arg Ile Val Pro Ser Leu Ala Glu Gly Leu Asp
         250                 255                 260

 gat ggg gac acc cca ctc ttc ctg tca tct ctt aca gcc acc ggc ctg     1108
 Asp Gly Asp Thr Pro Leu Phe Leu Ser Ser Leu Thr Ala Thr Gly Leu
     265                 270                 275

 ttc tga gcgcttgctc cagcctggag gacgctca                              1142
 Phe 
 280





      <210> 146
      <211> 1884
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (1)..(1884)

      <400> 146
  atg gca gga ggc tca gcc acg acc tgg ggt tac cct gtg gcc ctg cta      48
  Met Ala Gly Gly Ser Ala Thr Thr Trp Gly Tyr Pro Val Ala Leu Leu
    1               5                  10                  15

 ctg ctg gtc gcc acc ctg ggg ctg ggc ctc cgg cac agc tac gac tgt       96
 Leu Leu Val Ala Thr Leu Gly Leu Gly Leu Arg His Ser Tyr Asp Cys
              20                  25                  30

 ggg atc aag gga atg cag ctg ctg gtg ttc ccc agg cca ggc cag act      144
 Gly Ile Lys Gly Met Gln Leu Leu Val Phe Pro Arg Pro Gly Gln Thr
          35                  40                  45

 ctc cgc ttc aag gtg gtg gat gaa ttt ggg aac cga ttt gat gtc aac      192
 Leu Arg Phe Lys Val Val Asp Glu Phe Gly Asn Arg Phe Asp Val Asn
      50                  55                  60

 aac tgc tcc atc tgc tac cac tgg gtc acc tcc agg ccg cag gag cct      240
 Asn Cys Ser Ile Cys Tyr His Trp Val Thr Ser Arg Pro Gln Glu Pro
  65                  70                  75                  80

 gca gtc ttc tcg gcc gat tac aga ggc tgc cac gtg ctg gag aag gat      288
 Ala Val Phe Ser Ala Asp Tyr Arg Gly Cys His Val Leu Glu Lys Asp
                  85                  90                  95

 ggg cgt ttc cac ctg agg gtg ttc atg gag gct gtg ctg ccc aat ggt      336
 Gly Arg Phe His Leu Arg Val Phe Met Glu Ala Val Leu Pro Asn Gly
             100                 105                 110

 cgt gtg gat gtg gca caa gac gct act ctg atc tgt ccc aaa cct gac      384
 Arg Val Asp Val Ala Gln Asp Ala Thr Leu Ile Cys Pro Lys Pro Asp
         115                 120                 125

 ccc tcc cgg act ctg gac tcc cag ctg gca cca ccc gcc atg ttc tct      432
 Pro Ser Arg Thr Leu Asp Ser Gln Leu Ala Pro Pro Ala Met Phe Ser
     130                 135                 140

 gtc tca acc cca caa acc ctt tcc ttc ctc ccc acc tct ggc cat acc      480
 Val Ser Thr Pro Gln Thr Leu Ser Phe Leu Pro Thr Ser Gly His Thr
 145                 150                 155                 160

 tcc caa ggc tct ggc cat gcc ttt ccc agc cca ctg gac cca ggg cac      528
 Ser Gln Gly Ser Gly His Ala Phe Pro Ser Pro Leu Asp Pro Gly His
                 165                 170                 175

 agc tct gtc cac cca acc cct gct tta cca tcc cct gga cct gga cct      576
 Ser Ser Val His Pro Thr Pro Ala Leu Pro Ser Pro Gly Pro Gly Pro
             180                 185                 190

 acc ctc gcc acc ctg gct caa ccc cac tgg ggc acc ttg gaa cac tgg      624
 Thr Leu Ala Thr Leu Ala Gln Pro His Trp Gly Thr Leu Glu His Trp
         195                 200                 205

 gat gtg aac aaa cga gat tac ata ggt acc cac ctg agc cag gag cag      672
 Asp Val Asn Lys Arg Asp Tyr Ile Gly Thr His Leu Ser Gln Glu Gln
     210                 215                 220

 tgc cag gtg gcc tca ggg cac ctc ccc tgc atc gtg aga aga act tca      720
 Cys Gln Val Ala Ser Gly His Leu Pro Cys Ile Val Arg Arg Thr Ser
 225                 230                 235                 240

 aaa gaa gcc tgt cag cag gct ggc tgc tgc tat gac aac acc aga gag      768
 Lys Glu Ala Cys Gln Gln Ala Gly Cys Cys Tyr Asp Asn Thr Arg Glu
                 245                 250                 255

 gtt ccc tgt tac tat ggc aac aca gct act gtc cag tgc ttc aga gat      816
 Val Pro Cys Tyr Tyr Gly Asn Thr Ala Thr Val Gln Cys Phe Arg Asp
             260                 265                 270

 ggc tac ttc gtc ctc gta gtg tcc caa gaa atg gcc ttg aca cac agg      864
 Gly Tyr Phe Val Leu Val Val Ser Gln Glu Met Ala Leu Thr His Arg
         275                 280                 285

 atc aca ctg gcc aac atc cac ctg gcc tat gcc ccc acc agc tgc tcc      912
 Ile Thr Leu Ala Asn Ile His Leu Ala Tyr Ala Pro Thr Ser Cys Ser
     290                 295                 300

 cca aca cag cac acg gaa gct ttc gtg gtc ttc tac ttc cct ctc acc      960
 Pro Thr Gln His Thr Glu Ala Phe Val Val Phe Tyr Phe Pro Leu Thr
 305                 310                 315                 320

 cac tgt gga acc aca atg cag gtg gct ggc gac cag ctc atc tat gag     1008
 His Cys Gly Thr Thr Met Gln Val Ala Gly Asp Gln Leu Ile Tyr Glu
                 325                 330                 335

 aac tgg ctg gtg tct ggc atc cac atc caa aag ggg cca cag ggt tcc     1056
 Asn Trp Leu Val Ser Gly Ile His Ile Gln Lys Gly Pro Gln Gly Ser
             340                 345                 350

 atc acg cgg gac agc acc ttc cag ctt cat gtg cgc tgt gtc ttc aac     1104
 Ile Thr Arg Asp Ser Thr Phe Gln Leu His Val Arg Cys Val Phe Asn
         355                 360                 365

 gcc agt gac ttc ctg ccc att cag gca tcc att ttc cca ccc cca tcg     1152
 Ala Ser Asp Phe Leu Pro Ile Gln Ala Ser Ile Phe Pro Pro Pro Ser
     370                 375                 380

 cct gct cct atg acc cag ccc ggc ccc ctg cgg ctt gag ctg cgg att     1200
 Pro Ala Pro Met Thr Gln Pro Gly Pro Leu Arg Leu Glu Leu Arg Ile
 385                 390                 395                 400

 gcc aaa gac gag acc ttc agc tcg tac tat ggg gag gat gac tat ccc     1248
 Ala Lys Asp Glu Thr Phe Ser Ser Tyr Tyr Gly Glu Asp Asp Tyr Pro
                 405                 410                 415

 atc gtg agg ctg ctc cga gaa cca gtc cat gtg gag gtc cgg ctt ctg     1296
 Ile Val Arg Leu Leu Arg Glu Pro Val His Val Glu Val Arg Leu Leu
             420                 425                 430

 cag agg aca gac ccc aac ctg gtc ctg ctg ctg cac cag tgc tgg ggc     1344
 Gln Arg Thr Asp Pro Asn Leu Val Leu Leu Leu His Gln Cys Trp Gly
         435                 440                 445

 gct ccc agt gcc aac ccc ttc cag cag ccc cag tgg ccc atc ctg tca     1392
 Ala Pro Ser Ala Asn Pro Phe Gln Gln Pro Gln Trp Pro Ile Leu Ser
     450                 455                 460

 gac gga tgc cct ttc aag ggc gac agc tac aga acc caa atg gta gcc     1440
 Asp Gly Cys Pro Phe Lys Gly Asp Ser Tyr Arg Thr Gln Met Val Ala
 465                 470                 475                 480

 ttg gac ggg gcc aca cct ttc cag tcg cac tac cag cga ttc act gtt     1488
 Leu Asp Gly Ala Thr Pro Phe Gln Ser His Tyr Gln Arg Phe Thr Val
                 485                 490                 495

 gct acc ttc gcc ctc ctg gac tca ggc tcc cag aga gcc ctc aga gga     1536
 Ala Thr Phe Ala Leu Leu Asp Ser Gly Ser Gln Arg Ala Leu Arg Gly
             500                 505                 510

 ctg gtt tac ttg ttc tgc agc acc tct gcc tgc cac acc tca ggg ctg     1584
 Leu Val Tyr Leu Phe Cys Ser Thr Ser Ala Cys His Thr Ser Gly Leu
         515                 520                 525

 gag act tgc tcc act gca tgt agc act ggc act aca aga cag cga cga     1632
 Glu Thr Cys Ser Thr Ala Cys Ser Thr Gly Thr Thr Arg Gln Arg Arg
     530                 535                 540

 tcc tca ggt cac cgt aat gac act gcc agg ccc cag gac atc gtg agc     1680
 Ser Ser Gly His Arg Asn Asp Thr Ala Arg Pro Gln Asp Ile Val Ser
 545                 550                 555                 560

 tct ccg ggg cca gtg ggc ttt gag gat tct tat ggg cag gag ccc aca     1728
 Ser Pro Gly Pro Val Gly Phe Glu Asp Ser Tyr Gly Gln Glu Pro Thr
                 565                 570                 575

 ctt ggg ccc aca gac tcc aat ggg aac tcc agc ctg aga cct ctc ctt     1776
 Leu Gly Pro Thr Asp Ser Asn Gly Asn Ser Ser Leu Arg Pro Leu Leu
             580                 585                 590

 tgg gcg gtc ctt ttg ctg cca gct gtt gcc ctg gtc ctt ggg ttt ggt     1824
 Trp Ala Val Leu Leu Leu Pro Ala Val Ala Leu Val Leu Gly Phe Gly
         595                 600                 605

 gtc ttt gtg ggc ctg agc cag acc tgg gcc cag aag ctc tgg gaa agc     1872
 Val Phe Val Gly Leu Ser Gln Thr Trp Ala Gln Lys Leu Trp Glu Ser
     610                 615                 620

 aac aga cag tga                                                     1884
 Asn Arg Gln 
 625





      <210> 147
      <211> 1948
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (367)..(1683)

      <400> 147
 ggcagctgtt ttgggctgag gtgtccctag ctggctctgc ggctcttccg ggtctgggct     60

 cggagattca caggcggccc gcgaggccga gcgagggacg catggccctg aggcggccgc    120

 agggcttggc ggggtccgga ggttgacctc gcccccgcag ccggccttcg aggctgcctc    180

 ctccaggcag cctctggggc ccgcgcccgc gcctgctcag gctcccgtgt tcaggctgcc    240

 catcccctcc ccaccggcgt cccggacgtt gggacctgtg accgtggcct cgggctgggc    300

 ttccaaagcc ggccgcagcc cggcgacccc cgaggcctct cgccccgggc ccctagacct    360

 ctcact   atg acc gcg gcc gcc gcc tcc aac tgg ggg ctg atc acg aac     408
          Met Thr Ala Ala Ala Ala Ser Asn Trp Gly Leu Ile Thr Asn
            1               5                  10

 atc gtg aac agc atc gta ggg gtc agt gtc ctc acc atg ccc ttc tgc      456
 Ile Val Asn Ser Ile Val Gly Val Ser Val Leu Thr Met Pro Phe Cys
  15                  20                  25                  30

 ttc aaa cag tgc ggc atc gtc ctg ggg gcg ctg ctc ttg gtc ttc tgc      504
 Phe Lys Gln Cys Gly Ile Val Leu Gly Ala Leu Leu Leu Val Phe Cys
                  35                  40                  45

 tca tgg atg acg cac cag tcg tgc atg ttc ttg gtg aag tcg gcc agc      552
 Ser Trp Met Thr His Gln Ser Cys Met Phe Leu Val Lys Ser Ala Ser
              50                  55                  60

 ctg agc aag cgg agg acc tac gcc ggc ctg gca ttc cac gcc tac ggg      600
 Leu Ser Lys Arg Arg Thr Tyr Ala Gly Leu Ala Phe His Ala Tyr Gly
          65                  70                  75

 aag gca ggc aag atg ctg gtg gag acc agc atg atc ggg ctg atg ctg      648
 Lys Ala Gly Lys Met Leu Val Glu Thr Ser Met Ile Gly Leu Met Leu
      80                  85                  90

 ggc acc tgc atc gcc ttc tac gtc gtg atc ggc gac ttg ggg tcc aac      696
 Gly Thr Cys Ile Ala Phe Tyr Val Val Ile Gly Asp Leu Gly Ser Asn
  95                 100                 105                 110

 ttc ttt gcc cgg ctg ttc ggg ttt cag gtg ggc ggc acc ttc cgc atg      744
 Phe Phe Ala Arg Leu Phe Gly Phe Gln Val Gly Gly Thr Phe Arg Met
                 115                 120                 125

 ttc ctg ctg ttc gcc gtg tcg ctg tgc atc gtg ctc ccg ctc agc ctg      792
 Phe Leu Leu Phe Ala Val Ser Leu Cys Ile Val Leu Pro Leu Ser Leu
             130                 135                 140

 cag cgg aac atg atg gcc tcc atc cag tcc ttc agc gcc atg gcc ctc      840
 Gln Arg Asn Met Met Ala Ser Ile Gln Ser Phe Ser Ala Met Ala Leu
         145                 150                 155

 ctc ttc tac acc gtg ttc atg ttc gtg atc gtg ctc tcc tct ctc aag      888
 Leu Phe Tyr Thr Val Phe Met Phe Val Ile Val Leu Ser Ser Leu Lys
     160                 165                 170

 cac ggc ctc ttc agt ggg cag tgg ctg cgg cgg gtc agc tac gtc cgc      936
 His Gly Leu Phe Ser Gly Gln Trp Leu Arg Arg Val Ser Tyr Val Arg
 175                 180                 185                 190

 tgg gag ggc gtc ttc cgc tgc atc ccc atc ttc ggc atg tcc ttc gcc      984
 Trp Glu Gly Val Phe Arg Cys Ile Pro Ile Phe Gly Met Ser Phe Ala
                 195                 200                 205

 tgc cag tcc cag gtg ctg ccc acc tac gac agc ctg gat gag ccg tca     1032
 Cys Gln Ser Gln Val Leu Pro Thr Tyr Asp Ser Leu Asp Glu Pro Ser
             210                 215                 220

 gtg aaa acc atg agc tcc ata ttt gct tcc tcc ctt aat gtg gtc acc     1080
 Val Lys Thr Met Ser Ser Ile Phe Ala Ser Ser Leu Asn Val Val Thr
         225                 230                 235

 acc ttc tac gtc atg gtg ggg ttt ttc ggc tac gtc agc ttc acc gag     1128
 Thr Phe Tyr Val Met Val Gly Phe Phe Gly Tyr Val Ser Phe Thr Glu
     240                 245                 250

 gcc acg gcc ggc aac gtg ctc atg cac ttt ccc tcc aac ctg gtg acg     1176
 Ala Thr Ala Gly Asn Val Leu Met His Phe Pro Ser Asn Leu Val Thr
 255                 260                 265                 270

 gag atg ctc cgt gtg ggc ttc atg atg tca gtg gct gtg ggc ttc ccc     1224
 Glu Met Leu Arg Val Gly Phe Met Met Ser Val Ala Val Gly Phe Pro
                 275                 280                 285

 atg atg atc ctg cca tgc agg cag gcc ctg agc acg ctg ctg tgt gag     1272
 Met Met Ile Leu Pro Cys Arg Gln Ala Leu Ser Thr Leu Leu Cys Glu
             290                 295                 300

 cag cag caa aaa gat ggc acc ttt gca gca ggg ggc tac atg ccc cct     1320
 Gln Gln Gln Lys Asp Gly Thr Phe Ala Ala Gly Gly Tyr Met Pro Pro
         305                 310                 315

 ctc cgg ttt aaa gca ctt acc ctc tct gtg gtg ttt gga acc atg gtt     1368
 Leu Arg Phe Lys Ala Leu Thr Leu Ser Val Val Phe Gly Thr Met Val
     320                 325                 330

 ggt ggc atc ctt atc ccc aac gtg gag acc atc ctg ggc ctc aca gga     1416
 Gly Gly Ile Leu Ile Pro Asn Val Glu Thr Ile Leu Gly Leu Thr Gly
 335                 340                 345                 350

 gcg acc atg gga agc ctc atc tgc ttc atc tgc ccc ggc gct gat cta     1464
 Ala Thr Met Gly Ser Leu Ile Cys Phe Ile Cys Pro Gly Ala Asp Leu
                 355                 360                 365

 caa gaa aat cca caa gaa cgc act ttc ctc cca ggt ggt gct gtg ggt     1512
 Gln Glu Asn Pro Gln Glu Arg Thr Phe Leu Pro Gly Gly Ala Val Gly
             370                 375                 380

 cgg cct ggg cgt cct ggt ggt gag cac tgt cac cac act gtc tgt gag     1560
 Arg Pro Gly Arg Pro Gly Gly Glu His Cys His His Thr Val Cys Glu
         385                 390                 395

 cga gga ggt ccc cga gga ctt ggc aga gga agc ccc tgg cgg ccg gct     1608
 Arg Gly Gly Pro Arg Gly Leu Gly Arg Gly Ser Pro Trp Arg Pro Ala
     400                 405                 410

 tgg aga ggc cga ggg ttt gat gaa ggt gga ggc agc gcg gct ctc agc     1656
 Trp Arg Gly Arg Gly Phe Asp Glu Gly Gly Gly Ser Ala Ala Leu Ser
 415                 420                 425                 430

 cca gga tcc ggt tgt ggc cgt ggc tga ggatg gccgggagaa gccgaagctg     1708
 Pro Gly Ser Gly Cys Gly Arg Gly 
                 435

 ccgaaggaga gagaggagct ggagcaggcc cagatcaagg ggcccaggcg gaacgatacg   1768

 gcagcgccgc ggagcctcgg ttggcctcgg atagccggtc ccccgcctgt ccccgccggc   1828

 gggccgcccc cccctccacg cgccccgcgc gcgcgggagg gcgcgtgccc cgccgcgcgc   1888

 cgggaccggg gtccggtgcg gagtgccctt cgtcctggga aacggggcgc ggctggaaag   1948




      <210> 148
      <211> 1505
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (231)..(1505)

      <400> 148
 ccaagagatt ctgattcaac aggtctgacg tggagctgga gaatttgcat ttgtagtaag     60

 tttcaggtgt tgctactgct gcttgtccag gactactgat tattctcgtg tccacggaca    120

 gcagaatacg gctgtaatag gtagctgtta aggtagatgt taaggccatt gttactatcg    180

 tcaactgagg ctaagtcctg ggtgggcttt ttgctgtgcc aaatgccccc   atg aag     236
                                                          Met Lys
                                                            1

 tcg ccg ttc tac cgc tgc cag aac acc acc tct gtg gaa aaa ggc aac      284
 Ser Pro Phe Tyr Arg Cys Gln Asn Thr Thr Ser Val Glu Lys Gly Asn
           5                  10                  15

 tcg gcg gtg atg ggc ggg gtg ctc ttc agc acc ggc ctc ctg ggc aac      332
 Ser Ala Val Met Gly Gly Val Leu Phe Ser Thr Gly Leu Leu Gly Asn
      20                  25                  30

 ctg ctg gcc ctg ggg ctg ctg gcg cgc tcg ggg ctg ggg tgg tgc tcg      380
 Leu Leu Ala Leu Gly Leu Leu Ala Arg Ser Gly Leu Gly Trp Cys Ser
  35                  40                  45                  50

 cgg cgt cca ctg cgc ccg ctg ccc tcg gtc ttc tac atg ctg gtg tgt      428
 Arg Arg Pro Leu Arg Pro Leu Pro Ser Val Phe Tyr Met Leu Val Cys
                  55                  60                  65

 ggc ctg acg gtc acc gac ttg ctg ggc aag tgc ctc cta agc ccg gtg      476
 Gly Leu Thr Val Thr Asp Leu Leu Gly Lys Cys Leu Leu Ser Pro Val
              70                  75                  80

 gtg ctg gct gcc tac gct cag aac cgg agt ctg cgg gtg ctt gcg ccc      524
 Val Leu Ala Ala Tyr Ala Gln Asn Arg Ser Leu Arg Val Leu Ala Pro
          85                  90                  95

 gca ttg gac aac tcg ttg tgc caa gcc ttc gcc ttc ttc atg tcc ttc      572
 Ala Leu Asp Asn Ser Leu Cys Gln Ala Phe Ala Phe Phe Met Ser Phe
     100                 105                 110

 ttt ggg ctc tcc tcg aca ctg caa ctc ctg gcc atg gca ctg gag tgc      620
 Phe Gly Leu Ser Ser Thr Leu Gln Leu Leu Ala Met Ala Leu Glu Cys
 115                 120                 125                 130

 tgg ctc tcc cta ggg cac cct ttc ttc tac cga cgg cac atc acc ctg      668
 Trp Leu Ser Leu Gly His Pro Phe Phe Tyr Arg Arg His Ile Thr Leu
                 135                 140                 145

 cgc ctg ggc gca ctg gtg gcc ccg gtg gtg agc gcc ttc tcc ctg gct      716
 Arg Leu Gly Ala Leu Val Ala Pro Val Val Ser Ala Phe Ser Leu Ala
             150                 155                 160

 ttc tgc gcg cta cct ttc atg ggc ttc ggg aag ttc gtg cag tac tgc      764
 Phe Cys Ala Leu Pro Phe Met Gly Phe Gly Lys Phe Val Gln Tyr Cys
         165                 170                 175

 ccc ggc acc tgg tgc ttt atc cag atg gtc cac gag gag ggc tcg ctg      812
 Pro Gly Thr Trp Cys Phe Ile Gln Met Val His Glu Glu Gly Ser Leu
     180                 185                 190

 tcg gtg ctg ggg tac tct gtg ctc tac tcc agc ctc atg gcg ctg ctg      860
 Ser Val Leu Gly Tyr Ser Val Leu Tyr Ser Ser Leu Met Ala Leu Leu
 195                 200                 205                 210

 gtc ctc gcc acc gtg ctg tgc aac ctc ggc gcc atg cgc aac ctc tat      908
 Val Leu Ala Thr Val Leu Cys Asn Leu Gly Ala Met Arg Asn Leu Tyr
                 215                 220                 225

 gcg atg cac cgg cgg ctg cag cgg cac ccg cgc tcc tgc acc agg gac      956
 Ala Met His Arg Arg Leu Gln Arg His Pro Arg Ser Cys Thr Arg Asp
             230                 235                 240

 tgt gcc gag ccg cgc gcg gac ggg agg gaa gcg tcc cct cag ccc ctg     1004
 Cys Ala Glu Pro Arg Ala Asp Gly Arg Glu Ala Ser Pro Gln Pro Leu
         245                 250                 255

 gag gag ctg gat cac ctc ctg ctg ctg gcg ctg atg acc gtg ctc ttc     1052
 Glu Glu Leu Asp His Leu Leu Leu Leu Ala Leu Met Thr Val Leu Phe
     260                 265                 270

 act atg tgt tct ctg ccc gta att gtg agt ccc cgg gcc ccg agg cag     1100
 Thr Met Cys Ser Leu Pro Val Ile Val Ser Pro Arg Ala Pro Arg Gln
 275                 280                 285                 290

 cag ggc act gag act gtc cgg ccg cgg atg cgg ggc ggg aag ggt gga     1148
 Gln Gly Thr Glu Thr Val Arg Pro Arg Met Arg Gly Gly Lys Gly Gly
                 295                 300                 305

 gcg gat cgg gat gga cgc ggc gcc agg cga gct gcg ccc tgg gcc agg     1196
 Ala Asp Arg Asp Gly Arg Gly Ala Arg Arg Ala Ala Pro Trp Ala Arg
             310                 315                 320

 aag tat cgc gct tac tat gga gca ttt aag gat gtc aag gag aaa aac     1244
 Lys Tyr Arg Ala Tyr Tyr Gly Ala Phe Lys Asp Val Lys Glu Lys Asn
         325                 330                 335

 agg acc tct gaa gaa gca gaa gac ctc cga gcc ttg cga ttt cta tct     1292
 Arg Thr Ser Glu Glu Ala Glu Asp Leu Arg Ala Leu Arg Phe Leu Ser
     340                 345                 350

 gtg att tca att gtg gac cct tgg att ttt atc att ttc aga tct cca     1340
 Val Ile Ser Ile Val Asp Pro Trp Ile Phe Ile Ile Phe Arg Ser Pro
 355                 360                 365                 370

 gta ttt cgg ata ttt ttt cac aag att ttc att aga cct ctt agc tac     1388
 Val Phe Arg Ile Phe Phe His Lys Ile Phe Ile Arg Pro Leu Ser Tyr
                 375                 380                 385

 cta tta cag ccg tat tct gct gtc cgt gga cac ggt aag atc tta ggt     1436
 Leu Leu Gln Pro Tyr Ser Ala Val Arg Gly His Gly Lys Ile Leu Gly
             390                 395                 400

 tcc aag att tta ctt caa att aca cct tca aaa ctg gag cag cat ata     1484
 Ser Lys Ile Leu Leu Gln Ile Thr Pro Ser Lys Leu Glu Gln His Ile
         405                 410                 415

 gcc gaa aag gag cac aac tga                                         1505
 Ala Glu Lys Glu His Asn 
     420





      <210> 149
      <211> 1707
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (1)..(1707)

      <400> 149
  atg gcc tcg gcg ctg atc tat gtc tcc aag ttc aag tcc ttc gtg atc      48
  Met Ala Ser Ala Leu Ile Tyr Val Ser Lys Phe Lys Ser Phe Val Ile
    1               5                  10                  15

 ttg gtc ggg acc ccg ctc ctg ctg ctg cca ctc gtc att ctg atg ccc       96
 Leu Val Gly Thr Pro Leu Leu Leu Leu Pro Leu Val Ile Leu Met Pro
              20                  25                  30

 gcc aag ttt gtc agg tgt gcc tac gtc atc atc ctc atg gcc att tac      144
 Ala Lys Phe Val Arg Cys Ala Tyr Val Ile Ile Leu Met Ala Ile Tyr
          35                  40                  45

 tgg tgc aca gaa gtc atc cct ctg gct gtc acc tct ctc atg cct gtc      192
 Trp Cys Thr Glu Val Ile Pro Leu Ala Val Thr Ser Leu Met Pro Val
      50                  55                  60

 ttg ctt ttc cca ctc ttc cag att ctg gac tcc agg cag gtg tgt gtc      240
 Leu Leu Phe Pro Leu Phe Gln Ile Leu Asp Ser Arg Gln Val Cys Val
  65                  70                  75                  80

 cag tac atg aag gac acc aac atg ctg ttc ctg ggc ggc ctc atc gtg      288
 Gln Tyr Met Lys Asp Thr Asn Met Leu Phe Leu Gly Gly Leu Ile Val
                  85                  90                  95

 gcc gtg gct gtg gag cgc tgg aac ctg cac aag agg atc gcc ctg cgc      336
 Ala Val Ala Val Glu Arg Trp Asn Leu His Lys Arg Ile Ala Leu Arg
             100                 105                 110

 acg ctc ctc tgg gtg ggg gcc aag cct gca cgg ctg atg ctg ggc ttc      384
 Thr Leu Leu Trp Val Gly Ala Lys Pro Ala Arg Leu Met Leu Gly Phe
         115                 120                 125

 atg ggc gtc aca gcc ctc ctg tcc atg tgg atc agt aac acg gca acc      432
 Met Gly Val Thr Ala Leu Leu Ser Met Trp Ile Ser Asn Thr Ala Thr
     130                 135                 140

 acg gcc atg atg gtg ccc atc gtg gag gcc ata ttg cag cag atg gaa      480
 Thr Ala Met Met Val Pro Ile Val Glu Ala Ile Leu Gln Gln Met Glu
 145                 150                 155                 160

 gcc aca agc gca gcc acc gag gcc ggc ctg gag ctg gtg gac aag ggc      528
 Ala Thr Ser Ala Ala Thr Glu Ala Gly Leu Glu Leu Val Asp Lys Gly
                 165                 170                 175

 aag gcc aag gag ctg cca ggg agt caa gtg att ttt gaa ggc ccc act      576
 Lys Ala Lys Glu Leu Pro Gly Ser Gln Val Ile Phe Glu Gly Pro Thr
             180                 185                 190

 ctg ggg cag cag gaa gac caa gag cgg aag agg ttg tgt aag gcc atg      624
 Leu Gly Gln Gln Glu Asp Gln Glu Arg Lys Arg Leu Cys Lys Ala Met
         195                 200                 205

 acc ctg tgc atc tgc tac gcg gcc agc atc ggg ggc acc gcc acc ctg      672
 Thr Leu Cys Ile Cys Tyr Ala Ala Ser Ile Gly Gly Thr Ala Thr Leu
     210                 215                 220

 acc ggg acg gga ccc aac gtg gtg ctc ctg ggc cag atg aac gag ttg      720
 Thr Gly Thr Gly Pro Asn Val Val Leu Leu Gly Gln Met Asn Glu Leu
 225                 230                 235                 240

 ttt cct gac agc aag gac ctc gtg aac ttt gct tcc tgg ttt gca ttt      768
 Phe Pro Asp Ser Lys Asp Leu Val Asn Phe Ala Ser Trp Phe Ala Phe
                 245                 250                 255

 gcc ttt ccc aac atg ctg gtg atg ctg ctg ttc gcc tgg ctg tgg ctc      816
 Ala Phe Pro Asn Met Leu Val Met Leu Leu Phe Ala Trp Leu Trp Leu
             260                 265                 270

 cag ttt gtt tac atg aga ttc aat ttt aaa aag tcc tgg ggc tgc ggg      864
 Gln Phe Val Tyr Met Arg Phe Asn Phe Lys Lys Ser Trp Gly Cys Gly
         275                 280                 285

 cta gag agc aag aaa aac gag aag gct gcc ctc aag gtg ctg cag gag      912
 Leu Glu Ser Lys Lys Asn Glu Lys Ala Ala Leu Lys Val Leu Gln Glu
     290                 295                 300

 gag tac cgg aag ctg ggg ccc ttg tcc ttc gcg gag atc aac gtg ctg      960
 Glu Tyr Arg Lys Leu Gly Pro Leu Ser Phe Ala Glu Ile Asn Val Leu
 305                 310                 315                 320

 atc tgc ttc ttc ctg ctg gtc atc ctg tgg ttc tcc cga gac ccc ggc     1008
 Ile Cys Phe Phe Leu Leu Val Ile Leu Trp Phe Ser Arg Asp Pro Gly
                 325                 330                 335

 ttc atg ccc ggc tgg ctg act gtt gcc tgg gtg gag ggt gag aca aag     1056
 Phe Met Pro Gly Trp Leu Thr Val Ala Trp Val Glu Gly Glu Thr Lys
             340                 345                 350

 tat gtc tcc gat gcc act gtg gcc atc ttt gtg gcc acc ctg cta ttc     1104
 Tyr Val Ser Asp Ala Thr Val Ala Ile Phe Val Ala Thr Leu Leu Phe
         355                 360                 365

 att gtg cct tca cag aag ccc aag ttt aac ttc cgc agc cag act gag     1152
 Ile Val Pro Ser Gln Lys Pro Lys Phe Asn Phe Arg Ser Gln Thr Glu
     370                 375                 380

 gaa gaa agg aaa act cca ttt tat ccc cct ccc ctg ctg gat tgg aag     1200
 Glu Glu Arg Lys Thr Pro Phe Tyr Pro Pro Pro Leu Leu Asp Trp Lys
 385                 390                 395                 400

 gta acc cag gag aaa gtg ccc tgg ggc atc gtg ctg cta cta ggg ggc     1248
 Val Thr Gln Glu Lys Val Pro Trp Gly Ile Val Leu Leu Leu Gly Gly
                 405                 410                 415

 gga ttt gct ctg gct aaa gga tcc gag gcc tcg ggg ctg tcc gtg tgg     1296
 Gly Phe Ala Leu Ala Lys Gly Ser Glu Ala Ser Gly Leu Ser Val Trp
             420                 425                 430

 atg ggg aag cag atg gag ccc ttg cac gca gtg ccc ccg gca gcc atc     1344
 Met Gly Lys Gln Met Glu Pro Leu His Ala Val Pro Pro Ala Ala Ile
         435                 440                 445

 acc ttg atc ttg tcc ttg ctc gtt gcc gtg ttc act gag tgc aca agc     1392
 Thr Leu Ile Leu Ser Leu Leu Val Ala Val Phe Thr Glu Cys Thr Ser
     450                 455                 460

 aac gtg gcc acc acc acc ttg ttc ctg ccc atc ttt gcc tcc atg tct     1440
 Asn Val Ala Thr Thr Thr Leu Phe Leu Pro Ile Phe Ala Ser Met Ser
 465                 470                 475                 480

 cgc tcc atc ggc ctc aat ccg ctg tac atc atg ctg ccc tgt acc ctg     1488
 Arg Ser Ile Gly Leu Asn Pro Leu Tyr Ile Met Leu Pro Cys Thr Leu
                 485                 490                 495

 agt gcc tcc ttt gcc ttc atg ttg cct gtg gcc acc cct cca aat gcc     1536
 Ser Ala Ser Phe Ala Phe Met Leu Pro Val Ala Thr Pro Pro Asn Ala
             500                 505                 510

 atc gtg ttc acc tat ggg cac ctc aag gtt gct gac atg gtg aaa aca     1584
 Ile Val Phe Thr Tyr Gly His Leu Lys Val Ala Asp Met Val Lys Thr
         515                 520                 525

 gga gtc ata atg aac ata att gga gtc ttc tgt gtg ttt ttg gct gtc     1632
 Gly Val Ile Met Asn Ile Ile Gly Val Phe Cys Val Phe Leu Ala Val
     530                 535                 540

 aac acc tgg gga cgg gcc ata ttt gac ttg gat cat ttc cct gac tgg     1680
 Asn Thr Trp Gly Arg Ala Ile Phe Asp Leu Asp His Phe Pro Asp Trp
 545                 550                 555                 560

 gct aat gtg aca cat att gag act tag                                 1707
 Ala Asn Val Thr His Ile Glu Thr 
                 565





      <210> 150
      <211> 1217
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (108)..(1217)

      <400> 150
 cacgggcaca gctcgccagc actgcgaacc cggatgggtc gtcgggcgcg gccctcagca     60

 gagctgcctt cacagatgtg gtgcccagtt ctgagaaatc gagaaac  atg ata agg     116
                                                      Met Ile Arg
                                                        1

 aat tgg ctg act att ttt atc ctt ttt ccc ctg aag ctc gta gag aaa      164
 Asn Trp Leu Thr Ile Phe Ile Leu Phe Pro Leu Lys Leu Val Glu Lys
       5                  10                  15

 tgt gat agt cag ccc cag gaa ggg gac cag tgc cag gag tca agc gtc      212
 Cys Asp Ser Gln Pro Gln Glu Gly Asp Gln Cys Gln Glu Ser Ser Val
  20                  25                  30                  35

 agc ctc act gtt cct cct gtc gta aag ctg gag aac ggc agc tcg acc      260
 Ser Leu Thr Val Pro Pro Val Val Lys Leu Glu Asn Gly Ser Ser Thr
                  40                  45                  50

 aac gtc agc ctc acc ctg cgg cca cca tta aat gca acc ctg gtg atc      308
 Asn Val Ser Leu Thr Leu Arg Pro Pro Leu Asn Ala Thr Leu Val Ile
              55                  60                  65

 act ttt gaa atc aca ttt cgt tcc aaa aat att act atc ctt gag ctc      356
 Thr Phe Glu Ile Thr Phe Arg Ser Lys Asn Ile Thr Ile Leu Glu Leu
          70                  75                  80

 ccc gat gaa ttc cag aag gga ttt agt ggc cac tta aca aat atg caa      404
 Pro Asp Glu Phe Gln Lys Gly Phe Ser Gly His Leu Thr Asn Met Gln
      85                  90                  95

 gca acg ttg caa gga ata tct gtt aaa aat aag aaa aac ccg agg ata      452
 Ala Thr Leu Gln Gly Ile Ser Val Lys Asn Lys Lys Asn Pro Arg Ile
 100                 105                 110                 115

 cgc ttt ctt gtg atc cgc agc agc gcc att agc atc ata aac cag gtg      500
 Arg Phe Leu Val Ile Arg Ser Ser Ala Ile Ser Ile Ile Asn Gln Val
                 120                 125                 130

 att ggc tgg atc tac ttt gtg gcc tgg tcc atc tcc ttc tac cct cag      548
 Ile Gly Trp Ile Tyr Phe Val Ala Trp Ser Ile Ser Phe Tyr Pro Gln
             135                 140                 145

 gtg atc atg aat tgg agg cgg aaa agt gtc att ggt ctg agc ttc gac      596
 Val Ile Met Asn Trp Arg Arg Lys Ser Val Ile Gly Leu Ser Phe Asp
         150                 155                 160

 ttc gtg gct ctg aac ctg acg ggc ttc gtg gcc tac agt gta ttc aac      644
 Phe Val Ala Leu Asn Leu Thr Gly Phe Val Ala Tyr Ser Val Phe Asn
     165                 170                 175

 atc ggc ctc ctc tgg gtg ccc tac atc aag gag cag ttt ctc ctc aaa      692
 Ile Gly Leu Leu Trp Val Pro Tyr Ile Lys Glu Gln Phe Leu Leu Lys
 180                 185                 190                 195

 tac ccc aac gga gtg aac ccc gtg aac agc aac gac gtc ttc ttc agc      740
 Tyr Pro Asn Gly Val Asn Pro Val Asn Ser Asn Asp Val Phe Phe Ser
                 200                 205                 210

 ctg cac gcg gtt gtc ctc acg ctg atc atc atc gtg cag tgc tgc ctg      788
 Leu His Ala Val Val Leu Thr Leu Ile Ile Ile Val Gln Cys Cys Leu
             215                 220                 225

 tat gag cgc ggt ggc cag cgc gtg tcc tgg cct gcc atc ggc ttc ctg      836
 Tyr Glu Arg Gly Gly Gln Arg Val Ser Trp Pro Ala Ile Gly Phe Leu
         230                 235                 240

 gtg ctc gcg tgg ctc ttc gca ttt gtc acc atg atc gtg gct gca gtg      884
 Val Leu Ala Trp Leu Phe Ala Phe Val Thr Met Ile Val Ala Ala Val
     245                 250                 255

 gga gtg atc acg tgg ctg cag ttt ctc ttc tgc ttc tcc tac atc aag      932
 Gly Val Ile Thr Trp Leu Gln Phe Leu Phe Cys Phe Ser Tyr Ile Lys
 260                 265                 270                 275

 ctc gca gtc acg ctg gtc aag tat ttt cca cag gcc tac atg aac ttt      980
 Leu Ala Val Thr Leu Val Lys Tyr Phe Pro Gln Ala Tyr Met Asn Phe
                 280                 285                 290

 tac tac aaa agc act gag ggc tgg agc att ggc aac gtg ctc ctg gac     1028
 Tyr Tyr Lys Ser Thr Glu Gly Trp Ser Ile Gly Asn Val Leu Leu Asp
             295                 300                 305

 ttc acc ggg ggc agc ttc agc ctc ctg cag atg ttc ctc cag tcc tac     1076
 Phe Thr Gly Gly Ser Phe Ser Leu Leu Gln Met Phe Leu Gln Ser Tyr
         310                 315                 320

 aac aac gac cag tgg acg ctg atc ttc gga gac cca acc aag ttt gga     1124
 Asn Asn Asp Gln Trp Thr Leu Ile Phe Gly Asp Pro Thr Lys Phe Gly
     325                 330                 335

 ctc ggg gtc ttc tcc atc gtc ttc gac gtc gtc ttc ttc atc cag cac     1172
 Leu Gly Val Phe Ser Ile Val Phe Asp Val Val Phe Phe Ile Gln His
 340                 345                 350                 355

 ttc tgt ttg tac aga aag aga ccg ggg tat gac cag ctg aac tag         1217
 Phe Cys Leu Tyr Arg Lys Arg Pro Gly Tyr Asp Gln Leu Asn 
                 360                 365





      <210> 151
      <211> 454
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (53)..(454)

      <400> 151
 gaattcccgg gtcgagcctc gcccctctgc tccgactcgc cggaccgacg cg    atg      55
                                                              Met
                                                                1

 gcc tca gaa gtg gtg tgc ggg ctc atc ttc agg ctg ctg ctg ccc atc      103
 Ala Ser Glu Val Val Cys Gly Leu Ile Phe Arg Leu Leu Leu Pro Ile
               5                  10                  15

 tgc ctg gca gta gca tgt gca ttc cga tac aat ggg ctc tcc ttt gtc      151
 Cys Leu Ala Val Ala Cys Ala Phe Arg Tyr Asn Gly Leu Ser Phe Val
          20                  25                  30

 tac ctt atc tac ctc ttg ctc att cct ctg ttc tca gaa cca aca aaa      199
 Tyr Leu Ile Tyr Leu Leu Leu Ile Pro Leu Phe Ser Glu Pro Thr Lys
      35                  40                  45

 acg acg atg caa gga cat acg gga cgg tta tta aag tct ctg tgc ttc      247
 Thr Thr Met Gln Gly His Thr Gly Arg Leu Leu Lys Ser Leu Cys Phe
  50                  55                  60                  65

 atc agt ctt tcc ttc ctg ttg ctg cac atc att ttc cac atc acg ttg      295
 Ile Ser Leu Ser Phe Leu Leu Leu His Ile Ile Phe His Ile Thr Leu
                  70                  75                  80

 gtg agc ctt gaa gct caa cat cgt att gca cct ggc tac aac tgc aaa      343
 Val Ser Leu Glu Ala Gln His Arg Ile Ala Pro Gly Tyr Asn Cys Lys
              85                  90                  95

 aag tca caa tac ctg gac act tca ggt ggg acc tct act agt acc atg      391
 Lys Ser Gln Tyr Leu Asp Thr Ser Gly Gly Thr Ser Thr Ser Thr Met
         100                 105                 110

 aag aag gga gtg gtg aag gga ggt gat ggt gaa ggg agg cct tcc ttg      439
 Lys Lys Gly Val Val Lys Gly Gly Asp Gly Glu Gly Arg Pro Ser Leu
     115                 120                 125

 ccc aac cag tat taa                                                  454
 Pro Asn Gln Tyr 
 130





      <210> 152
      <211> 937
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (44)..(811)

      <400> 152
 gaatgtgtac acgcccagct tcctgcctgt tactctccac agt  atg cga aga ata      55
                                                  Met Arg Arg Ile
                                                    1

 tcc ctg act tct agc cct gtg cgc ctt ctt ttg ttt ctg ctg ttg cta      103
 Ser Leu Thr Ser Ser Pro Val Arg Leu Leu Leu Phe Leu Leu Leu Leu
   5                  10                  15                  20

 cta ata gcc ttg gag atc atg gtt ggt ggt cac tct ctt tgc ttc aac      151
 Leu Ile Ala Leu Glu Ile Met Val Gly Gly His Ser Leu Cys Phe Asn
                  25                  30                  35

 ttc act ata aaa tca ttg tcc aga cct gga cag ccc tgg tgt gaa gcg      199
 Phe Thr Ile Lys Ser Leu Ser Arg Pro Gly Gln Pro Trp Cys Glu Ala
              40                  45                  50

 cag gtc ttc ttg aat aaa aat ctt ttc ctt cag tac aac agt gac aac      247
 Gln Val Phe Leu Asn Lys Asn Leu Phe Leu Gln Tyr Asn Ser Asp Asn
          55                  60                  65

 aac atg gtc aaa cct atg ggc ctc ctg ggg aag aag gta aat gcc acc      295
 Asn Met Val Lys Pro Met Gly Leu Leu Gly Lys Lys Val Asn Ala Thr
      70                  75                  80

 agc act tgg gga gag ttg acc caa acg ctg gga gaa gtg ggg cga gac      343
 Ser Thr Trp Gly Glu Leu Thr Gln Thr Leu Gly Glu Val Gly Arg Asp
  85                  90                  95                 100

 ctc agg atg ctc ctt tgt gac atc aaa ccc cag ata aag acc agt gat      391
 Leu Arg Met Leu Leu Cys Asp Ile Lys Pro Gln Ile Lys Thr Ser Asp
                 105                 110                 115

 cct tcc act ctg caa gtc gag atg ttt tgt caa cgt gaa gca gaa cgg      439
 Pro Ser Thr Leu Gln Val Glu Met Phe Cys Gln Arg Glu Ala Glu Arg
             120                 125                 130

 tgc act ggt gca tcc tgg cag ttc gcc acc aat gga gag aaa tcc ctc      487
 Cys Thr Gly Ala Ser Trp Gln Phe Ala Thr Asn Gly Glu Lys Ser Leu
         135                 140                 145

 ctc ttt gac gca atg aac atg acc tgg aca gta att aat cat gaa gcc      535
 Leu Phe Asp Ala Met Asn Met Thr Trp Thr Val Ile Asn His Glu Ala
     150                 155                 160

 agt aag atc aag gag aca tgg aag aaa gac aga ggg ctg gaa aag tat      583
 Ser Lys Ile Lys Glu Thr Trp Lys Lys Asp Arg Gly Leu Glu Lys Tyr
 165                 170                 175                 180

 ttc agg aag ctc tca aag gga gac tgc gat cac tgg ctc agg gaa ttc      631
 Phe Arg Lys Leu Ser Lys Gly Asp Cys Asp His Trp Leu Arg Glu Phe
                 185                 190                 195

 tta ggg cac tgg gag gca atg cca gaa ccg aca gtg tca cca gta aat      679
 Leu Gly His Trp Glu Ala Met Pro Glu Pro Thr Val Ser Pro Val Asn
             200                 205                 210

 gct tca gat atc cac tgg tct tct tct agt cta cca gat aga tgg atc      727
 Ala Ser Asp Ile His Trp Ser Ser Ser Ser Leu Pro Asp Arg Trp Ile
         215                 220                 225

 atc ctg ggg gca ttc atc ctg tta ctt tta atg gga att gtt ctc atc      775
 Ile Leu Gly Ala Phe Ile Leu Leu Leu Leu Met Gly Ile Val Leu Ile
     230                 235                 240

 tgt gtc tgg tgg caa aat ggc aga aga tcc acc tag aggt gataccacgg      825
 Cys Val Trp Trp Gln Asn Gly Arg Arg Ser Thr 
 245                 250                 255

 cggcgcagag ttgttcacct gtggtcctcg atcgctgaca gccttggctc ccactgctgt    885

 gtgttccctg agtcaagtgg aggcggagcc tgcaatgagc ggagatcgcg ct            937




      <210> 153
      <211> 1181
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (129)..(1181)

      <400> 153
 caggcaggtg caggcgccgc ggggccggat cctccgcgcg gccgagtcca tctcctggga     60

 aatggggcgg acagtgtttc cttgactgac tattgtgagc gccctctctc tccggcggag    120

 cggagacc atg gcc ccc act cag ggc ccc cgg gcc ccg ctg gaa ttc gga     170
          Met Ala Pro Thr Gln Gly Pro Arg Ala Pro Leu Glu Phe Gly
            1               5                  10

 ggg ccc ctg ggc gcc gcg gct ctg cta ctg ctg ctg ccc gcc acc atg      218
 Gly Pro Leu Gly Ala Ala Ala Leu Leu Leu Leu Leu Pro Ala Thr Met
  15                  20                  25                  30

 ttc cac ctg ctc ctg gcg gcc cgt tcg ggc ccc gcg cgc ctg ctg ggt      266
 Phe His Leu Leu Leu Ala Ala Arg Ser Gly Pro Ala Arg Leu Leu Gly
                  35                  40                  45

 cca ccc gcg tcc ctg ccc ggg ctg gag gtg ctg tgg agc cca cgg gcg      314
 Pro Pro Ala Ser Leu Pro Gly Leu Glu Val Leu Trp Ser Pro Arg Ala
              50                  55                  60

 ctg ctg ctg tgg ctc gcc tgg ctc ggc ctg cag gcg gcg ctc tac cta      362
 Leu Leu Leu Trp Leu Ala Trp Leu Gly Leu Gln Ala Ala Leu Tyr Leu
          65                  70                  75

 ctg ccg gcg cgc aag gtg gcc gag ggg cag gaa ttg aag gac aag agt      410
 Leu Pro Ala Arg Lys Val Ala Glu Gly Gln Glu Leu Lys Asp Lys Ser
      80                  85                  90

 cgc ctg cgc tat cct att aac ggc ttc cag gcc ctg gtg ctg aca gcc      458
 Arg Leu Arg Tyr Pro Ile Asn Gly Phe Gln Ala Leu Val Leu Thr Ala
  95                 100                 105                 110

 ctg ttg gtg ggg ctg ggg atg tca gcg ggg ctg cct ctg ggg gcg ctc      506
 Leu Leu Val Gly Leu Gly Met Ser Ala Gly Leu Pro Leu Gly Ala Leu
                 115                 120                 125

 ccg gaa atg ctc ctg ccc ttg gcg ttt gtc gcc acc ctc acc gct ttc      554
 Pro Glu Met Leu Leu Pro Leu Ala Phe Val Ala Thr Leu Thr Ala Phe
             130                 135                 140

 atc ttc agc ctt ttt ctc tac atg aag gcg cag gta gcc cca gtt tcg      602
 Ile Phe Ser Leu Phe Leu Tyr Met Lys Ala Gln Val Ala Pro Val Ser
         145                 150                 155

 gcc ctg gca cct ggg ggg aac tca ggc aat ccg att tac gac ttt ttt      650
 Ala Leu Ala Pro Gly Gly Asn Ser Gly Asn Pro Ile Tyr Asp Phe Phe
     160                 165                 170

 ctg gga cga gag ctc aac cct cgt atc tgt ttc ttc gac ttc aaa tat      698
 Leu Gly Arg Glu Leu Asn Pro Arg Ile Cys Phe Phe Asp Phe Lys Tyr
 175                 180                 185                 190

 ttc tgt gaa ctg cga ccc ggc ctc atc ggc tgg gtc ctc atc aac ctg      746
 Phe Cys Glu Leu Arg Pro Gly Leu Ile Gly Trp Val Leu Ile Asn Leu
                 195                 200                 205

 gcc ctg ttg atg aag gag gca gag ctt cga ggc agt ccc tca ctg gcc      794
 Ala Leu Leu Met Lys Glu Ala Glu Leu Arg Gly Ser Pro Ser Leu Ala
             210                 215                 220

 atg tgg ctg gtc aat ggc ttc cag ttg ctc tac gtg ggt gat gcc ctc      842
 Met Trp Leu Val Asn Gly Phe Gln Leu Leu Tyr Val Gly Asp Ala Leu
         225                 230                 235

 tgg cac gag gag gcc gtc ctc acc acc atg gat atc aca cat gac ggg      890
 Trp His Glu Glu Ala Val Leu Thr Thr Met Asp Ile Thr His Asp Gly
     240                 245                 250

 ttt ggc ttc atg ctg gcg ttt ggg gac atg gcc tgg gtg ccc ttc acc      938
 Phe Gly Phe Met Leu Ala Phe Gly Asp Met Ala Trp Val Pro Phe Thr
 255                 260                 265                 270

 tac agc ctg cag gcc cag ttc ctg ctg cac cac ccg cag ccc ctg ggg      986
 Tyr Ser Leu Gln Ala Gln Phe Leu Leu His His Pro Gln Pro Leu Gly
                 275                 280                 285

 ttg ccc atg gcc tct gtc atc tgc ctc atc aat ggg gtg tca cac ctg     1034
 Leu Pro Met Ala Ser Val Ile Cys Leu Ile Asn Gly Val Ser His Leu
             290                 295                 300

 ctg ccc tac ttc tac ctc ctc tac ttc acc gcg ctg ctg gtg cac cgt     1082
 Leu Pro Tyr Phe Tyr Leu Leu Tyr Phe Thr Ala Leu Leu Val His Arg
         305                 310                 315

 gag gcc cgg gat gag cgg cag tgc ctg cag aag tac ggc ctg gcc tgg     1130
 Glu Ala Arg Asp Glu Arg Gln Cys Leu Gln Lys Tyr Gly Leu Ala Trp
     320                 325                 330

 cag gag tac tgc cgg cgt gtg cct tac cgc atc atg ccc tac atc tac     1178
 Gln Glu Tyr Cys Arg Arg Val Pro Tyr Arg Ile Met Pro Tyr Ile Tyr
 335                 340                 345                 350

 tga                                                                 1181
 






      <210> 154
      <211> 2952
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (1)..(2952)

      <400> 154
  atg cgg ctg ggc tcc ggg act ttc gct acc tgt tgc gta gcg atc gag      48
  Met Arg Leu Gly Ser Gly Thr Phe Ala Thr Cys Cys Val Ala Ile Glu
    1               5                  10                  15

 gtg cta ggg atc gcg gtc ttc ctt cgg gga ttc ttc ccg gct ccc gtt       96
 Val Leu Gly Ile Ala Val Phe Leu Arg Gly Phe Phe Pro Ala Pro Val
              20                  25                  30

 cgt tcc tct gcc aga gcg gaa cac gga gcg gag ccc cca gcg ccc gaa      144
 Arg Ser Ser Ala Arg Ala Glu His Gly Ala Glu Pro Pro Ala Pro Glu
          35                  40                  45

 ccc tcg gct gga gcc agt tct aac tgg acc acg ctg cca cca cct ctc      192
 Pro Ser Ala Gly Ala Ser Ser Asn Trp Thr Thr Leu Pro Pro Pro Leu
      50                  55                  60

 ttc agt aaa gtt gtt att gtt ctg ata gat gcc ttg aga gat gat ttt      240
 Phe Ser Lys Val Val Ile Val Leu Ile Asp Ala Leu Arg Asp Asp Phe
  65                  70                  75                  80

 gtg ttt ggg tca aag ggt gtg aaa ttt atg ccc tac aca act tac ctt      288
 Val Phe Gly Ser Lys Gly Val Lys Phe Met Pro Tyr Thr Thr Tyr Leu
                  85                  90                  95

 gtg gaa aaa gga gca tct cac agt ttt gtg gct gaa gca aag cca cct      336
 Val Glu Lys Gly Ala Ser His Ser Phe Val Ala Glu Ala Lys Pro Pro
             100                 105                 110

 aca gtt act atg cct cga atc aag gca ttg atg acg ggg agc ctt cct      384
 Thr Val Thr Met Pro Arg Ile Lys Ala Leu Met Thr Gly Ser Leu Pro
         115                 120                 125

 ggc ttt gtc gac gtc atc agg aac ctc aat tct cct gca ctg ctg gaa      432
 Gly Phe Val Asp Val Ile Arg Asn Leu Asn Ser Pro Ala Leu Leu Glu
     130                 135                 140

 gac agt gtg ata aga caa gca aaa gca gct gga aaa aga ata gtc ttt      480
 Asp Ser Val Ile Arg Gln Ala Lys Ala Ala Gly Lys Arg Ile Val Phe
 145                 150                 155                 160

 tat gga gat gaa acc tgg gtt aaa tta ttc cca aag cat ttt gtg gaa      528
 Tyr Gly Asp Glu Thr Trp Val Lys Leu Phe Pro Lys His Phe Val Glu
                 165                 170                 175

 tat gat gga aca acc tca ttt ttc gtg tca gat tac aca gag gtg gat      576
 Tyr Asp Gly Thr Thr Ser Phe Phe Val Ser Asp Tyr Thr Glu Val Asp
             180                 185                 190

 aat aat gtc acg agg cat ttg gat aaa gta tta aaa aga gga gat tgg      624
 Asn Asn Val Thr Arg His Leu Asp Lys Val Leu Lys Arg Gly Asp Trp
         195                 200                 205

 gac ata tta atc ctc cac tac ctg ggg ctg gac cac att ggc cac att      672
 Asp Ile Leu Ile Leu His Tyr Leu Gly Leu Asp His Ile Gly His Ile
     210                 215                 220

 tca ggg ccc aac agc ccc ctg att ggg cag aag ctg agc gag atg gac      720
 Ser Gly Pro Asn Ser Pro Leu Ile Gly Gln Lys Leu Ser Glu Met Asp
 225                 230                 235                 240

 agc gtg ctg atg aag atc cac acc tca ctg cag tcg aag gag aga gag      768
 Ser Val Leu Met Lys Ile His Thr Ser Leu Gln Ser Lys Glu Arg Glu
                 245                 250                 255

 acg cct tta ccc aat ttg ctg gtt ctt tgt ggt gac cat ggc atg tct      816
 Thr Pro Leu Pro Asn Leu Leu Val Leu Cys Gly Asp His Gly Met Ser
             260                 265                 270

 gaa aca gga agt cac ggg gcc tcc tcc acc gag gag ggg aat aca cct      864
 Glu Thr Gly Ser His Gly Ala Ser Ser Thr Glu Glu Gly Asn Thr Pro
         275                 280                 285

 ctg att tta atc agt tct gcg ttt gaa agg aaa ccc ggt gat atc cga      912
 Leu Ile Leu Ile Ser Ser Ala Phe Glu Arg Lys Pro Gly Asp Ile Arg
     290                 295                 300

 cat cca aag cac gtc caa cag acg gat gtg gct gcg aca ctg gcg ata      960
 His Pro Lys His Val Gln Gln Thr Asp Val Ala Ala Thr Leu Ala Ile
 305                 310                 315                 320

 gca ctt ggc tta ccg att cca aaa gac agt gta ggg agc ctc cta ttc     1008
 Ala Leu Gly Leu Pro Ile Pro Lys Asp Ser Val Gly Ser Leu Leu Phe
                 325                 330                 335

 cca gtt gtg gaa gga aga cca atg aga gag cag ttg aga ttt tta cat     1056
 Pro Val Val Glu Gly Arg Pro Met Arg Glu Gln Leu Arg Phe Leu His
             340                 345                 350

 ttg aat aca gtg cag ctt att aaa ctg ttg caa gag aat gtg ccg tca     1104
 Leu Asn Thr Val Gln Leu Ile Lys Leu Leu Gln Glu Asn Val Pro Ser
         355                 360                 365

 tat gaa aaa gat cct ggg ttt gag cag ttt aaa atg tca gaa aga ttg     1152
 Tyr Glu Lys Asp Pro Gly Phe Glu Gln Phe Lys Met Ser Glu Arg Leu
     370                 375                 380

 cat ggg aac tgg atc aga ctg tac ttg gag gaa aag cat tca gaa gtc     1200
 His Gly Asn Trp Ile Arg Leu Tyr Leu Glu Glu Lys His Ser Glu Val
 385                 390                 395                 400

 cta ttc aac ctg ggc tcc aag gtt ctc agg cag tac ctg gat gct ctg     1248
 Leu Phe Asn Leu Gly Ser Lys Val Leu Arg Gln Tyr Leu Asp Ala Leu
                 405                 410                 415

 aag acg ctg agc ttg tcc ctg agt gca caa gtg gcc cag tac gac atc     1296
 Lys Thr Leu Ser Leu Ser Leu Ser Ala Gln Val Ala Gln Tyr Asp Ile
             420                 425                 430

 tat tcg atg atg gtg ggg act gtc gtg gtt ttg gag gtt ctc acc ctg     1344
 Tyr Ser Met Met Val Gly Thr Val Val Val Leu Glu Val Leu Thr Leu
         435                 440                 445

 ctc ctg ctc agc gtc cca cag gca ctg cgc aga aag gct gag ctg gaa     1392
 Leu Leu Leu Ser Val Pro Gln Ala Leu Arg Arg Lys Ala Glu Leu Glu
     450                 455                 460

 gtc cca ctg tca tct cct ggg ttt tct ctg ctc ttt tat ttg gtg atc     1440
 Val Pro Leu Ser Ser Pro Gly Phe Ser Leu Leu Phe Tyr Leu Val Ile
 465                 470                 475                 480

 ctg gtt ctt tcg gcc gtt cac gtc att gtg tgc acc tca gct gaa agt     1488
 Leu Val Leu Ser Ala Val His Val Ile Val Cys Thr Ser Ala Glu Ser
                 485                 490                 495

 tcg tgc tac ttc tgt ggc ctc tcg tgg ctg gcg gca ggt ggg gtg atg     1536
 Ser Cys Tyr Phe Cys Gly Leu Ser Trp Leu Ala Ala Gly Gly Val Met
             500                 505                 510

 gtg ctg gcc tcg gcg ctg ctg tgt gtg att gtg tct gtt ctg acc aac     1584
 Val Leu Ala Ser Ala Leu Leu Cys Val Ile Val Ser Val Leu Thr Asn
         515                 520                 525

 gtg ctc gtg ggt gga aac acc cca agg aag aac ccc atg cat ccc agc     1632
 Val Leu Val Gly Gly Asn Thr Pro Arg Lys Asn Pro Met His Pro Ser
     530                 535                 540

 tca agg tgg tca gag cta gac ctt ctt att ctg ttg ggg acg gcg ggc     1680
 Ser Arg Trp Ser Glu Leu Asp Leu Leu Ile Leu Leu Gly Thr Ala Gly
 545                 550                 555                 560

 cac gtc ttg agc ctg ggc gcc agc agc ttc gtg gag gag gag cac cag     1728
 His Val Leu Ser Leu Gly Ala Ser Ser Phe Val Glu Glu Glu His Gln
                 565                 570                 575

 acc tgg tac ttc ctt gtg aac acc ctg tgt cta gct ctg agc caa gaa     1776
 Thr Trp Tyr Phe Leu Val Asn Thr Leu Cys Leu Ala Leu Ser Gln Glu
             580                 585                 590

 acc tac aga aac tac ttt ctg gga gat gac ggt gag cct ccg tgt ggc     1824
 Thr Tyr Arg Asn Tyr Phe Leu Gly Asp Asp Gly Glu Pro Pro Cys Gly
         595                 600                 605

 ctc tgt gtg gaa caa ggg cat gac ggg gcc aca gca gcg tgg cag gac     1872
 Leu Cys Val Glu Gln Gly His Asp Gly Ala Thr Ala Ala Trp Gln Asp
     610                 615                 620

 ggg cct ggc tgt gat gtc ctg gag cga gac aaa ggc cac gga agc ccc     1920
 Gly Pro Gly Cys Asp Val Leu Glu Arg Asp Lys Gly His Gly Ser Pro
 625                 630                 635                 640

 tct acc tcc gaa gtg ctc aga ggc cgc gag aag tgg atg gtg ctg gcc     1968
 Ser Thr Ser Glu Val Leu Arg Gly Arg Glu Lys Trp Met Val Leu Ala
                 645                 650                 655

 agt ccg tgg cta ata ctg gcc tgc tgc cgg ctg ctg cgc tcc cta aac     2016
 Ser Pro Trp Leu Ile Leu Ala Cys Cys Arg Leu Leu Arg Ser Leu Asn
             660                 665                 670

 cag aca ggt gtg cag tgg gct cac cgg cct gac ctc ggc cac tgg ctc     2064
 Gln Thr Gly Val Gln Trp Ala His Arg Pro Asp Leu Gly His Trp Leu
         675                 680                 685

 acc agc tct gac cac aaa gcc gag ctc tct gtc ctg gct gcc ctc tcc     2112
 Thr Ser Ser Asp His Lys Ala Glu Leu Ser Val Leu Ala Ala Leu Ser
     690                 695                 700

 ctc ctc gta gtt ttt gtg ctg gtg cag agg ggg tgc tcc cct gtg tcc     2160
 Leu Leu Val Val Phe Val Leu Val Gln Arg Gly Cys Ser Pro Val Ser
 705                 710                 715                 720

 aag gct gcc ctg gcg ctg ggg ctg ctg ggc gtc tac tgc tac cgg gcg     2208
 Lys Ala Ala Leu Ala Leu Gly Leu Leu Gly Val Tyr Cys Tyr Arg Ala
                 725                 730                 735

 gcc atc ggg agt gtc cgg ttc ccg tgg cgg ccg gac agc aag gac att     2256
 Ala Ile Gly Ser Val Arg Phe Pro Trp Arg Pro Asp Ser Lys Asp Ile
             740                 745                 750

 tcc aag ggt att att gaa gct cgt ttt gtt tat gtc ttt gtc ctt ggc     2304
 Ser Lys Gly Ile Ile Glu Ala Arg Phe Val Tyr Val Phe Val Leu Gly
         755                 760                 765

 att ctg ttc acg ggc acc aaa gac tta ctt aaa tct caa gtc att gct     2352
 Ile Leu Phe Thr Gly Thr Lys Asp Leu Leu Lys Ser Gln Val Ile Ala
     770                 775                 780

 gca gac ttc aaa ctc aag act gta ggt tta tgg gag ata tat agt gga     2400
 Ala Asp Phe Lys Leu Lys Thr Val Gly Leu Trp Glu Ile Tyr Ser Gly
 785                 790                 795                 800

 tta gtt ctt ctg gca gcc ttg ctc ttt aga cca cat aat ctt ccg gtc     2448
 Leu Val Leu Leu Ala Ala Leu Leu Phe Arg Pro His Asn Leu Pro Val
                 805                 810                 815

 tta gca ttt agc ctc ttg att cag act cta atg act aaa ttc atc tgg     2496
 Leu Ala Phe Ser Leu Leu Ile Gln Thr Leu Met Thr Lys Phe Ile Trp
             820                 825                 830

 aag ccc ctg aga cac gat gca gct gag att act gtg atg cat tat tgg     2544
 Lys Pro Leu Arg His Asp Ala Ala Glu Ile Thr Val Met His Tyr Trp
         835                 840                 845

 ttt ggt caa gca ttc ttc tat ttt cag ggc aac tcc aac aac att gcc     2592
 Phe Gly Gln Ala Phe Phe Tyr Phe Gln Gly Asn Ser Asn Asn Ile Ala
     850                 855                 860

 acc gtg gac atc tcc gca ggc ttc gtg ggc tta gac acc tac gtg gaa     2640
 Thr Val Asp Ile Ser Ala Gly Phe Val Gly Leu Asp Thr Tyr Val Glu
 865                 870                 875                 880

 atc cca gcc gtg ctc ctg aca gcg ttt ggg acg tac gca ggg cct gtg     2688
 Ile Pro Ala Val Leu Leu Thr Ala Phe Gly Thr Tyr Ala Gly Pro Val
                 885                 890                 895

 ctg tgg gcc agc cac tta gtg cac ttc ctg agc tca gaa aca cgc agt     2736
 Leu Trp Ala Ser His Leu Val His Phe Leu Ser Ser Glu Thr Arg Ser
             900                 905                 910

 ggt tca gca ctg agt cat gct tgc ttc tgc tac gca ctg att tgt tct     2784
 Gly Ser Ala Leu Ser His Ala Cys Phe Cys Tyr Ala Leu Ile Cys Ser
         915                 920                 925

 att cca gtt ttc acg tac atc gtt ttg gtg aca tct ctg cgt tat cat     2832
 Ile Pro Val Phe Thr Tyr Ile Val Leu Val Thr Ser Leu Arg Tyr His
     930                 935                 940

 tta ttt ata tgg agt gta ttt tct cca aaa ctt ctc tac gag gga atg     2880
 Leu Phe Ile Trp Ser Val Phe Ser Pro Lys Leu Leu Tyr Glu Gly Met
 945                 950                 955                 960

 cac ctg ctc att aca gct gct gtc tgt gta ttc ttc acg gca atg gat     2928
 His Leu Leu Ile Thr Ala Ala Val Cys Val Phe Phe Thr Ala Met Asp
                 965                 970                 975

 caa acc aga ctc aca cag tct tag                                     2952
 Gln Thr Arg Leu Thr Gln Ser 
             980





      <210> 155
      <211> 1496
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (48)..(1178)

      <400> 155
 agacaactca ggagatctgt tggaaagaga acgatagagg aaaatat  atg aat gtt      56
                                                      Met Asn Val
                                                        1

 gcc atc ttt aga aca ggc ccc atg ctg ctc tgg acg gct gtg ctg ctc      104
 Ala Ile Phe Arg Thr Gly Pro Met Leu Leu Trp Thr Ala Val Leu Leu
       5                  10                  15

 ttt gtt ccc tgt gtt ggg aaa act gtc tgg ctg tac ctc caa gcc tgg      152
 Phe Val Pro Cys Val Gly Lys Thr Val Trp Leu Tyr Leu Gln Ala Trp
  20                  25                  30                  35

 cca aac cct gtg ttt gaa gga gat gcc ctg act ctg cga tgt cag gga      200
 Pro Asn Pro Val Phe Glu Gly Asp Ala Leu Thr Leu Arg Cys Gln Gly
                  40                  45                  50

 tgg aag aat aca cca ctg tct cag gtg aag ttc tac aga gat gga aaa      248
 Trp Lys Asn Thr Pro Leu Ser Gln Val Lys Phe Tyr Arg Asp Gly Lys
              55                  60                  65

 ttc ctt cat ttc tct aag gaa aac cag act ctg tcc atg gga gca gca      296
 Phe Leu His Phe Ser Lys Glu Asn Gln Thr Leu Ser Met Gly Ala Ala
          70                  75                  80

 aca gtg cag agc cgt ggc cag tac agc tgc tct ggg cag gtg atg tat      344
 Thr Val Gln Ser Arg Gly Gln Tyr Ser Cys Ser Gly Gln Val Met Tyr
      85                  90                  95

 att cca cag aca ttc aca caa act tca gag act gcc atg gtt caa gtc      392
 Ile Pro Gln Thr Phe Thr Gln Thr Ser Glu Thr Ala Met Val Gln Val
 100                 105                 110                 115

 caa gag ctg ttt cca cct cct gtg ctg agt gcc atc ccc tct cct gag      440
 Gln Glu Leu Phe Pro Pro Pro Val Leu Ser Ala Ile Pro Ser Pro Glu
                 120                 125                 130

 ccc cga gag ggt agc ctg gtg acc ctg aga tgt cag aca aag ctg cac      488
 Pro Arg Glu Gly Ser Leu Val Thr Leu Arg Cys Gln Thr Lys Leu His
             135                 140                 145

 ccc ctg agg tca gcc ttg agg ctc ctt ttc tcc ttc cac aag gac ggc      536
 Pro Leu Arg Ser Ala Leu Arg Leu Leu Phe Ser Phe His Lys Asp Gly
         150                 155                 160

 cac acc ttg cag gac agg ggc cct cac cca gaa ctc tgc atc ccg gga      584
 His Thr Leu Gln Asp Arg Gly Pro His Pro Glu Leu Cys Ile Pro Gly
     165                 170                 175

 gcc aag gag gga gac tct ggg ctt tac tgg tgt gag gtg gcc cct gag      632
 Ala Lys Glu Gly Asp Ser Gly Leu Tyr Trp Cys Glu Val Ala Pro Glu
 180                 185                 190                 195

 ggt ggc cag gtc cag aag cag agc ccc cag ctg gag gtc aga gtg cag      680
 Gly Gly Gln Val Gln Lys Gln Ser Pro Gln Leu Glu Val Arg Val Gln
                 200                 205                 210

 gct cct gta tcc cgt cct gtg ctc act ctg cac cac ggg cct gct gac      728
 Ala Pro Val Ser Arg Pro Val Leu Thr Leu His His Gly Pro Ala Asp
             215                 220                 225

 cct gct gtg ggg gac atg gtg cag ctc ctc tgt gag gca cag agg ggc      776
 Pro Ala Val Gly Asp Met Val Gln Leu Leu Cys Glu Ala Gln Arg Gly
         230                 235                 240

 tcc cct ccg atc ctg tat tcc ttc tac ctt gat gag aag att gtg ggg      824
 Ser Pro Pro Ile Leu Tyr Ser Phe Tyr Leu Asp Glu Lys Ile Val Gly
     245                 250                 255

 aac cac tca gct ccc tgt ggt gga acc acc tcc ctc ctc ttc cca gtg      872
 Asn His Ser Ala Pro Cys Gly Gly Thr Thr Ser Leu Leu Phe Pro Val
 260                 265                 270                 275

 aag tca gaa cag gat gct ggg aac tac tcc tgc gag gct gag aac agt      920
 Lys Ser Glu Gln Asp Ala Gly Asn Tyr Ser Cys Glu Ala Glu Asn Ser
                 280                 285                 290

 gtc tcc aga gag agg agt gag ccc aag aag ctg tct ctg aag ggt tct      968
 Val Ser Arg Glu Arg Ser Glu Pro Lys Lys Leu Ser Leu Lys Gly Ser
             295                 300                 305

 caa gtc ttg ttc act ccc gcc agc aac tgg ctg gtt cct tgg ctt cct     1016
 Gln Val Leu Phe Thr Pro Ala Ser Asn Trp Leu Val Pro Trp Leu Pro
         310                 315                 320

 gcg agc ctg ctt ggc ctg atg gtt aat gct gct gca ctt ctg gtt tat     1064
 Ala Ser Leu Leu Gly Leu Met Val Asn Ala Ala Ala Leu Leu Val Tyr
     325                 330                 335

 gtg aga tcc tgg aga aaa gct ggg ccc ctt cca tcc cag ata cca ccc     1112
 Val Arg Ser Trp Arg Lys Ala Gly Pro Leu Pro Ser Gln Ile Pro Pro
 340                 345                 350                 355

 aca gct cca ggt gga gag cag tgc cca cta tat gcc aag gaa cca gcc     1160
 Thr Ala Pro Gly Gly Glu Gln Cys Pro Leu Tyr Ala Lys Glu Pro Ala
                 360                 365                 370

 agt tgc tgg cgg gag tga acaaga cttgagaacc cttcagagac agcttcttgg     1214
 Ser Cys Trp Arg Glu 
             375

 gctcactcct ctctctggag acactgttct cagcctcgca ggagtagttc ccagcatcct   1274

 gttctgactt cactgggaag aggagggagg tggttccacc acagggagct gagtggttcc   1334

 ccacaatctt ctcatcaagg tagaaggaat acaggatcgg aggggagccc ctctgtgcct   1394

 cacagaggag ctgcaccatg tcccccacag cagggtcagc aggcccgtgg tgcagagtga   1454

 gcacaggacg ggatacagga gcctgcactc tgacctccag cc                      1496




      <210> 156
      <211> 1118
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (55)..(933)

      <400> 156
 atggaaacaa tcacctgtaa tggatcaggg gactcctcaa ccaccttcta cctt  atg      57
                                                              Met
                                                                1

 ggc atc ccc tct ctg cca aaa tcc ctt ttc ctt cct att ttc ttt gtc      105
 Gly Ile Pro Ser Leu Pro Lys Ser Leu Phe Leu Pro Ile Phe Phe Val
               5                  10                  15

 ttt ctc ctc ctc tac gtg ctc atc ctg atg ggt aat acc ttt atc ctg      153
 Phe Leu Leu Leu Tyr Val Leu Ile Leu Met Gly Asn Thr Phe Ile Leu
          20                  25                  30

 gtg gct gtg gtg gcc aag ccc agc ctc cac aag ccc atg tac ttc ttc      201
 Val Ala Val Val Ala Lys Pro Ser Leu His Lys Pro Met Tyr Phe Phe
      35                  40                  45

 ctg ata aac ctc tcc acc ttg gac att ctt gtt acc aca acc act gtc      249
 Leu Ile Asn Leu Ser Thr Leu Asp Ile Leu Val Thr Thr Thr Thr Val
  50                  55                  60                  65

 ccc aag atg ctg tcc ctg ttc ttg ttt ggg gac agc ttc ctc agc ttc      297
 Pro Lys Met Leu Ser Leu Phe Leu Phe Gly Asp Ser Phe Leu Ser Phe
                  70                  75                  80

 cct gcc tgc ttc ctg cag atg tac ctg ttc cac agc ttc tcc tgc tca      345
 Pro Ala Cys Phe Leu Gln Met Tyr Leu Phe His Ser Phe Ser Cys Ser
              85                  90                  95

 gaa gcc ttc atc ctg gtg gtc atg gcc tat gac cgc tat gtg gct atc      393
 Glu Ala Phe Ile Leu Val Val Met Ala Tyr Asp Arg Tyr Val Ala Ile
         100                 105                 110

 tgc cgc cca ctg cac tac cct gtc ctc atg acc cct cag acc aac act      441
 Cys Arg Pro Leu His Tyr Pro Val Leu Met Thr Pro Gln Thr Asn Thr
     115                 120                 125

 gtc ttg aca acc agt gcc tgg ctc act gcc ctc ctc ctg ccc att cca      489
 Val Leu Thr Thr Ser Ala Trp Leu Thr Ala Leu Leu Leu Pro Ile Pro
 130                 135                 140                 145

 gca gtg gta cag acc tcc cag atg gca ttt gac atc att gtc cac atc      537
 Ala Val Val Gln Thr Ser Gln Met Ala Phe Asp Ile Ile Val His Ile
                 150                 155                 160

 tac cac tgc ttc tgt gac cac ctg gct gtg acc ttc atg ggc ttc tgc      585
 Tyr His Cys Phe Cys Asp His Leu Ala Val Thr Phe Met Gly Phe Cys
             165                 170                 175

 atc gcc atg gtg gtg tcc ttc ctc ccc ctt ctg ctg gtg ctt ctc tcc      633
 Ile Ala Met Val Val Ser Phe Leu Pro Leu Leu Leu Val Leu Leu Ser
         180                 185                 190

 tat gcc cac atc ttg acc tca gtg ctt tgc atc aac tgc caa gaa gga      681
 Tyr Ala His Ile Leu Thr Ser Val Leu Cys Ile Asn Cys Gln Glu Gly
     195                 200                 205

 cgc tcc aaa gcc ttc tcc acc tgc agc tcc cac ctc ctg gtg gtg ggc      729
 Arg Ser Lys Ala Phe Ser Thr Cys Ser Ser His Leu Leu Val Val Gly
 210                 215                 220                 225

 acc tac tat tca tcc att gcc ata gcc tat gtg gcc tac agg gct gac      777
 Thr Tyr Tyr Ser Ser Ile Ala Ile Ala Tyr Val Ala Tyr Arg Ala Asp
                 230                 235                 240

 ctg ccc cta gac ttc cac gtc atg ggc aat gtg gta tat gcc att ctc      825
 Leu Pro Leu Asp Phe His Val Met Gly Asn Val Val Tyr Ala Ile Leu
             245                 250                 255

 aca cct gtt ctc aac cct gtc atc tac aaa ctg agg aac aag gat gtc      873
 Thr Pro Val Leu Asn Pro Val Ile Tyr Lys Leu Arg Asn Lys Asp Val
         260                 265                 270

 aaa gca gcc atc acc aag att gca tgt ccc cag gag cca aag aat gct      921
 Lys Ala Ala Ile Thr Lys Ile Ala Cys Pro Gln Glu Pro Lys Asn Ala
     275                 280                 285

 agg aaa ccc tga ttc aaagaaataa cttcatcttc tctcataaac atcaataaca      976
 Arg Lys Pro 
 290

 tagagggaaa agtggaaaat ttagaaagcc cagtagttag aacactcatt ctcaaaatat   1036

 tgtcctaggt agtcctccat tataataaaa tgataatttt tttcttaatt catagaaaaa   1096

 agagtaggat ttttaaattc aa                                            1118




      <210> 157
      <211> 342
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (1)..(342)

      <400> 157
  atg gat aag ccc ctc ttc cca tta gtg cct ttg cat tgg ttt ggc ttt      48
  Met Asp Lys Pro Leu Phe Pro Leu Val Pro Leu His Trp Phe Gly Phe
    1               5                  10                  15

 ggc tac aca gca ctg gtt gtt tct ggt ggg atc gtt ggc tat gta aaa       96
 Gly Tyr Thr Ala Leu Val Val Ser Gly Gly Ile Val Gly Tyr Val Lys
              20                  25                  30

 aca ggc agc gtg ccg tct ctg gct gca ggg ctg ctc ttc ggc agt cta      144
 Thr Gly Ser Val Pro Ser Leu Ala Ala Gly Leu Leu Phe Gly Ser Leu
          35                  40                  45

 gcc ggc ctg ggt gct tac cag ctg tct cag gat cca agg aac gtt tgg      192
 Ala Gly Leu Gly Ala Tyr Gln Leu Ser Gln Asp Pro Arg Asn Val Trp
      50                  55                  60

 gtt ttc cta gct aca tct ggt acc ttg gct ggc att atg gga atg agg      240
 Val Phe Leu Ala Thr Ser Gly Thr Leu Ala Gly Ile Met Gly Met Arg
  65                  70                  75                  80

 ttc tac cac tct gga aaa ttc atg cct gca ggt tta att gca ggt gcc      288
 Phe Tyr His Ser Gly Lys Phe Met Pro Ala Gly Leu Ile Ala Gly Ala
                  85                  90                  95

 agt ttg ctg atg gtc gcc aaa gtt gga gtt agt atg ttc aac aga ccc      336
 Ser Leu Leu Met Val Ala Lys Val Gly Val Ser Met Phe Asn Arg Pro
             100                 105                 110

 cat tag                                                              342
 His 






      <210> 158
      <211> 2132
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (307)..(2085)

      <400> 158
 atgaagaggg tggatattgg agaccttggg gctgaggagg tggtggtagt tgaaattgtt     60

 gcttatgatg atgagatgta tattcaagag acagacgctg tctcagaggt cattagggat    120

 ggctctgggc ctatcagctg gtgtctgcaa ctagagatcc aagcaatccc ttccaactgg    180

 gatattgtcc accagggagt tgtctggtac acccaagcct tcttgggtat tcgccgactc    240

 tttgtgactc ttccagaccc tttgtgtcct ggccattctt gcgttttttc aatcctgagt    300

 tgtaca   atg gta gat gga gtg atg att ctt cct gtg ctt atc atg att     348
          Met Val Asp Gly Val Met Ile Leu Pro Val Leu Ile Met Ile
            1               5                  10

 gct ctc ccc tcc cct agt atg gaa gat gag aag ccc aag gtc aac ccc      396
 Ala Leu Pro Ser Pro Ser Met Glu Asp Glu Lys Pro Lys Val Asn Pro
  15                  20                  25                  30

 aaa ctc tac atg tgt gtg tgt gaa ggt ctc tcc tgc ggt aat gag gac      444
 Lys Leu Tyr Met Cys Val Cys Glu Gly Leu Ser Cys Gly Asn Glu Asp
                  35                  40                  45

 cac tgt gaa ggc cag cag tgc ttt tcc tca ctg agc atc aac gat ggc      492
 His Cys Glu Gly Gln Gln Cys Phe Ser Ser Leu Ser Ile Asn Asp Gly
              50                  55                  60

 ttc cac gtc tac cag aaa ggc tgc ttc cag gtt tat gag cag gga aag      540
 Phe His Val Tyr Gln Lys Gly Cys Phe Gln Val Tyr Glu Gln Gly Lys
          65                  70                  75

 atg acc tgt aag acc ccg ccg tcc cct ggc caa gcc gtg gag tgc tgc      588
 Met Thr Cys Lys Thr Pro Pro Ser Pro Gly Gln Ala Val Glu Cys Cys
      80                  85                  90

 caa ggg gac tgg tgt aac agg aac atc acg gcc cag ctg ccc act aaa      636
 Gln Gly Asp Trp Cys Asn Arg Asn Ile Thr Ala Gln Leu Pro Thr Lys
  95                 100                 105                 110

 gga aaa tcc ttc cct gga aca cag aat ttc cac ttg gag gtt ggc ctc      684
 Gly Lys Ser Phe Pro Gly Thr Gln Asn Phe His Leu Glu Val Gly Leu
                 115                 120                 125

 att att ctc tct gta gtg ttc gca gta tgt ctt tta gcc tgc ctg ctg      732
 Ile Ile Leu Ser Val Val Phe Ala Val Cys Leu Leu Ala Cys Leu Leu
             130                 135                 140

 gga gtt gct ctc cga aaa ttt aaa agg cgc aac caa gaa cgc ctc aat      780
 Gly Val Ala Leu Arg Lys Phe Lys Arg Arg Asn Gln Glu Arg Leu Asn
         145                 150                 155

 ccc cga gac gtg gag tat ggc act atc gaa ggg ctc atc acc acc aat      828
 Pro Arg Asp Val Glu Tyr Gly Thr Ile Glu Gly Leu Ile Thr Thr Asn
     160                 165                 170

 gtt gga gac agc act tta gca ggt tct aaa ttt ctt ccg ttg gat gct      876
 Val Gly Asp Ser Thr Leu Ala Gly Ser Lys Phe Leu Pro Leu Asp Ala
 175                 180                 185                 190

 cag ctt ttg gta att ttg ccg atc aac agt act tca cag tgg tgc tca      924
 Gln Leu Leu Val Ile Leu Pro Ile Asn Ser Thr Ser Gln Trp Cys Ser
                 195                 200                 205

 gaa gaa gtg aaa gaa gat gaa att cac aca aat caa tgt att gct tta      972
 Glu Glu Val Lys Glu Asp Glu Ile His Thr Asn Gln Cys Ile Ala Leu
             210                 215                 220

 agg agc ttt aca tgt aca cta aca ggc cac gtg tcc cgg att gct gcc     1020
 Arg Ser Phe Thr Cys Thr Leu Thr Gly His Val Ser Arg Ile Ala Ala
         225                 230                 235

 ctt cat gtc tac ggc tat tgt cac tgt ttg ctg ctt ctc gct tct cct     1068
 Leu His Val Tyr Gly Tyr Cys His Cys Leu Leu Leu Leu Ala Ser Pro
     240                 245                 250

 cca cgg cag att gtg aat gga gaa aat aaa gat gga aaa gcc cca aat     1116
 Pro Arg Gln Ile Val Asn Gly Glu Asn Lys Asp Gly Lys Ala Pro Asn
 255                 260                 265                 270

 gtg ctc att aat ttc aac cag agt tgt cct ctt gta cta act agt atc     1164
 Val Leu Ile Asn Phe Asn Gln Ser Cys Pro Leu Val Leu Thr Ser Ile
                 275                 280                 285

 tta ttt gat tat gaa caa gat tat ctg gat agt ggg aaa ggc agg tat     1212
 Leu Phe Asp Tyr Glu Gln Asp Tyr Leu Asp Ser Gly Lys Gly Arg Tyr
             290                 295                 300

 ggt gag gtg tgg agg ggc agc tgg caa ggg gag aat gtt gcc gtg aag     1260
 Gly Glu Val Trp Arg Gly Ser Trp Gln Gly Glu Asn Val Ala Val Lys
         305                 310                 315

 atc ttc tcc tcc cgt gat gag aag tca tgg ttc agg gaa acg gaa ttg     1308
 Ile Phe Ser Ser Arg Asp Glu Lys Ser Trp Phe Arg Glu Thr Glu Leu
     320                 325                 330

 tac aac act gtg atg ctg agg cat gaa aat atc tta ggt ttc att gct     1356
 Tyr Asn Thr Val Met Leu Arg His Glu Asn Ile Leu Gly Phe Ile Ala
 335                 340                 345                 350

 tca gac atg aca tca aga cac tcc agt acc cag ctg tgg tta att aca     1404
 Ser Asp Met Thr Ser Arg His Ser Ser Thr Gln Leu Trp Leu Ile Thr
                 355                 360                 365

 cat tat cat gaa atg gga tcg ttg tac gac tat ctt cag ctt act act     1452
 His Tyr His Glu Met Gly Ser Leu Tyr Asp Tyr Leu Gln Leu Thr Thr
             370                 375                 380

 ctg gat aca gtt agc tgc ctt cga ata gtg ctg tcc ata gct agt ggt     1500
 Leu Asp Thr Val Ser Cys Leu Arg Ile Val Leu Ser Ile Ala Ser Gly
         385                 390                 395

 ctt gca cat ttg cac ata gag ata ttt ggg acc caa ggg aaa cca gcc     1548
 Leu Ala His Leu His Ile Glu Ile Phe Gly Thr Gln Gly Lys Pro Ala
     400                 405                 410

 att gcc cat cga gat tta aag agc aaa aat att ctg gtt aag aag aat     1596
 Ile Ala His Arg Asp Leu Lys Ser Lys Asn Ile Leu Val Lys Lys Asn
 415                 420                 425                 430

 gga cag tgt tgc ata gca gat ttg ggc ctg gca gtc atg cat tcc cag     1644
 Gly Gln Cys Cys Ile Ala Asp Leu Gly Leu Ala Val Met His Ser Gln
                 435                 440                 445

 agc acc aat cag ctt gat gtg ggg aac aat ccc cgt gtg ggc acc aag     1692
 Ser Thr Asn Gln Leu Asp Val Gly Asn Asn Pro Arg Val Gly Thr Lys
             450                 455                 460

 cgc tac atg gcc ccc gaa gtt cta gat gaa acc atc cag gtg gat tgt     1740
 Arg Tyr Met Ala Pro Glu Val Leu Asp Glu Thr Ile Gln Val Asp Cys
         465                 470                 475

 ttc gat tct tat aaa agg gtc gat att tgg gcc ttt gga ctt gtt ttg     1788
 Phe Asp Ser Tyr Lys Arg Val Asp Ile Trp Ala Phe Gly Leu Val Leu
     480                 485                 490

 tgg gaa gtg gcc agg cgg atg gtg agc aat ggt ata gtg gag gat tac     1836
 Trp Glu Val Ala Arg Arg Met Val Ser Asn Gly Ile Val Glu Asp Tyr
 495                 500                 505                 510

 aag cca ccg ttc tac gat gtg gtt ccc aat gac cca agt ttt gaa gat     1884
 Lys Pro Pro Phe Tyr Asp Val Val Pro Asn Asp Pro Ser Phe Glu Asp
                 515                 520                 525

 atg agg aag gta gtc tgt gtg gat caa caa agg cca aac ata ccc aac     1932
 Met Arg Lys Val Val Cys Val Asp Gln Gln Arg Pro Asn Ile Pro Asn
             530                 535                 540

 aga tgg ttc tca gac ccg aca tta acc tct ctg gcc aag cta atg aaa     1980
 Arg Trp Phe Ser Asp Pro Thr Leu Thr Ser Leu Ala Lys Leu Met Lys
         545                 550                 555

 gaa tgc tgg tat caa aat cca tcc gca aga ctc aca gca ctg cgt atc     2028
 Glu Cys Trp Tyr Gln Asn Pro Ser Ala Arg Leu Thr Ala Leu Arg Ile
     560                 565                 570

 aaa aag act ttg acc aaa att gat aat tcc ctc gac aaa ttg aaa act     2076
 Lys Lys Thr Leu Thr Lys Ile Asp Asn Ser Leu Asp Lys Leu Lys Thr
 575                 580                 585                 590

 gac tgt tga cattttc atagtgtcaa gaaggaagat ttgacgttgt tgtcattgtc     2132
 Asp Cys 






      <210> 159
      <211> 1716
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (1)..(879)

      <400> 159
  atg cgg acg ccg gtg gtg atg acg ctg ggc atg gtg ttg gcg ccc tgc      48
  Met Arg Thr Pro Val Val Met Thr Leu Gly Met Val Leu Ala Pro Cys
    1               5                  10                  15

 ggg ctc ctg ctc aac ctg acc ggc acc ctg gcg ccc ggc tgg cgg ctg       96
 Gly Leu Leu Leu Asn Leu Thr Gly Thr Leu Ala Pro Gly Trp Arg Leu
              20                  25                  30

 gtg aag ggc ttc ctg aac cag cca gtg gac gtg gag ttg tac cag ggc      144
 Val Lys Gly Phe Leu Asn Gln Pro Val Asp Val Glu Leu Tyr Gln Gly
          35                  40                  45

 ctg tgg gac atg tgt cgc gag cag agc agc cgc gag cgc gag tgc ggc      192
 Leu Trp Asp Met Cys Arg Glu Gln Ser Ser Arg Glu Arg Glu Cys Gly
      50                  55                  60

 cag acg gac cag tgg ggc tac ttc gag gcc cag ccc gtg ctg gtg gcg      240
 Gln Thr Asp Gln Trp Gly Tyr Phe Glu Ala Gln Pro Val Leu Val Ala
  65                  70                  75                  80

 cgg gca ctc atg gtc acc tcg ctg gcc gcc acg gtc ctg ggg ctt ctg      288
 Arg Ala Leu Met Val Thr Ser Leu Ala Ala Thr Val Leu Gly Leu Leu
                  85                  90                  95

 ctg gcg tcg ctg ggc gtg cgc tgc tgg cag gac gag ccc aac ttc gtg      336
 Leu Ala Ser Leu Gly Val Arg Cys Trp Gln Asp Glu Pro Asn Phe Val
             100                 105                 110

 ctg gca ggg ctc tcg ggc gtc gtg ctc ttc gtc gct ggc ctc ctc ggc      384
 Leu Ala Gly Leu Ser Gly Val Val Leu Phe Val Ala Gly Leu Leu Gly
         115                 120                 125

 ctc atc ccg gtg tcc tgg tac aac cac ttc ttg ggg gac cgc gac gtg      432
 Leu Ile Pro Val Ser Trp Tyr Asn His Phe Leu Gly Asp Arg Asp Val
     130                 135                 140

 ctg ccc gcc ccg gcc agc ccg gtc acg gtg cag gtc agc tac agc ctg      480
 Leu Pro Ala Pro Ala Ser Pro Val Thr Val Gln Val Ser Tyr Ser Leu
 145                 150                 155                 160

 gtc ctg ggc tac ctg ggc agc tgc ctc ctg ctg ctg ggc ggc ttc tcg      528
 Val Leu Gly Tyr Leu Gly Ser Cys Leu Leu Leu Leu Gly Gly Phe Ser
                 165                 170                 175

 ctg gcg ctc agc ttc gcg ccc tgg tgc gac gag cgt tgt cgc cgc cgc      576
 Leu Ala Leu Ser Phe Ala Pro Trp Cys Asp Glu Arg Cys Arg Arg Arg
             180                 185                 190

 cgc aag gga ccc tcc gcc ggg cct cgc cgc agc agc gtc agc acc atc      624
 Arg Lys Gly Pro Ser Ala Gly Pro Arg Arg Ser Ser Val Ser Thr Ile
         195                 200                 205

 caa gtg gag tgg ccc gag ccc gac ctg gcg ccc gcc atc aag tac tac      672
 Gln Val Glu Trp Pro Glu Pro Asp Leu Ala Pro Ala Ile Lys Tyr Tyr
     210                 215                 220

 agc gac ggc cag cac cga ccg ccg cct gcc cag cac cgc aag ccc aag      720
 Ser Asp Gly Gln His Arg Pro Pro Pro Ala Gln His Arg Lys Pro Lys
 225                 230                 235                 240

 ccc aag ccc aag gtc ggc ttc ccc atg ccg cgg ccg cgg ccc aag gcc      768
 Pro Lys Pro Lys Val Gly Phe Pro Met Pro Arg Pro Arg Pro Lys Ala
                 245                 250                 255

 tac acc aac tcg gtg gac gtc ctc gac ggg gag ggg tgg gag tcc cag      816
 Tyr Thr Asn Ser Val Asp Val Leu Asp Gly Glu Gly Trp Glu Ser Gln
             260                 265                 270

 gac gct ccc tcg tgc agc acc cac ccc tgc gac agc tcg ctg ccc tgc      864
 Asp Ala Pro Ser Cys Ser Thr His Pro Cys Asp Ser Ser Leu Pro Cys
         275                 280                 285

 gac tcc gac ctc tag acgcttgtag agcctggggg gcgccgggtg gcaaaggact      919
 Asp Ser Asp Leu 
     290

 cacccccgca caggcccgcc tggcttcgag ttggaacccg gacacttgcc cctcactggt    979

 gtggatggaa atctgccttt cctgggacca aacaggactc cttggacgat tagttcaggt   1039

 tgggtttggt tttcttctta aagagtttag ttttcctctc cagagggatc agggtcctct   1099

 tagggagtga cgggcttttc atatattttt gctgaagaat atatggaaag ggtggcattt   1159

 gcgtcacgtg gaccagggac agtgctgaaa tcagcagtgc tcagaaacaa tttaacatgt   1219

 tgaaacgaca atattctaaa atactgatga atcttgcatc aatataatta ttgggttttt   1279

 tttctttttc ctgctgtata actccttgcc atgcaaactc tcaagaggcc aatatattcc   1339

 tggccatgtt tgaatgagcc tcttaaaata aacttagagc catgcaaatg ccagcagctt   1399

 aatggatttc atggaatgaa ataccgtgat taactcatag ctacatatca ttgcataaat   1459

 gggatttatc ttttttctca cttatttttt gctgtgaaag tcgagggcat gcaagagttt   1519

 ctcttccaga agccaggagg agaacgaagg tcctaatgct gtactattcc accctttgga   1579

 cgcctcatcc aggacgcaga ggactctagg tttaacattt tgtacaaaac agaacctgtt   1639

 aatcacatta aagcacatat gctatatatc ttttatttat aaataaaatt ttaaaacaat   1699

 aaaaaaaaaa aaaaaaa                                                  1716




      <210> 160
      <211> 1152
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (1)..(1152)

      <400> 160
  atg ggg ctg ggc ccg gtc ttc ctg ctt ctg gct ggc atc ttc cct ttt      48
  Met Gly Leu Gly Pro Val Phe Leu Leu Leu Ala Gly Ile Phe Pro Phe
    1               5                  10                  15

 gca cct ccg gga gct gct gct gag ccc cac agt ctt cgt tat aac ctc       96
 Ala Pro Pro Gly Ala Ala Ala Glu Pro His Ser Leu Arg Tyr Asn Leu
              20                  25                  30

 acg gtg ctg tcc tgg gat gga tct gtg cag tca ggg ttt ctt gct gag      144
 Thr Val Leu Ser Trp Asp Gly Ser Val Gln Ser Gly Phe Leu Ala Glu
          35                  40                  45

 gta cat ctg gat ggt cag ccc ttc ctg cgc tat gac agg cag aaa tgc      192
 Val His Leu Asp Gly Gln Pro Phe Leu Arg Tyr Asp Arg Gln Lys Cys
      50                  55                  60

 agg gca aag ccc cag gga cag tgg gca gaa gat gtc ctg gga aat aag      240
 Arg Ala Lys Pro Gln Gly Gln Trp Ala Glu Asp Val Leu Gly Asn Lys
  65                  70                  75                  80

 aca tgg gac aga gag acc agg gac ttg aca ggg aac gga aag gac ctc      288
 Thr Trp Asp Arg Glu Thr Arg Asp Leu Thr Gly Asn Gly Lys Asp Leu
                  85                  90                  95

 agg atg acc ctg gct cat atc aag gac cag aaa gaa ggc ttg cat tcc      336
 Arg Met Thr Leu Ala His Ile Lys Asp Gln Lys Glu Gly Leu His Ser
             100                 105                 110

 ctc cag gag att agg gtc tgt gag atc cat gaa gac aac agc acc agg      384
 Leu Gln Glu Ile Arg Val Cys Glu Ile His Glu Asp Asn Ser Thr Arg
         115                 120                 125

 agc tcc cag cat ttc tac tac gat ggg gag ctc ttc ctc tcc caa aac      432
 Ser Ser Gln His Phe Tyr Tyr Asp Gly Glu Leu Phe Leu Ser Gln Asn
     130                 135                 140

 gtg gag act gag gaa tgg aca gtg ccc cag tcc tcc aga gct cag acc      480
 Val Glu Thr Glu Glu Trp Thr Val Pro Gln Ser Ser Arg Ala Gln Thr
 145                 150                 155                 160

 ttg gcc atg aac gtc agg aat ttc ttg aag gaa gat gcc atg aag acc      528
 Leu Ala Met Asn Val Arg Asn Phe Leu Lys Glu Asp Ala Met Lys Thr
                 165                 170                 175

 aag aca cac tat cac gct atg cat gca gac tgc ctg cag gaa cta cgg      576
 Lys Thr His Tyr His Ala Met His Ala Asp Cys Leu Gln Glu Leu Arg
             180                 185                 190

 cga tat cta gaa tcc agc gta gtc ctg agg aga aga gtg ccc ccc atg      624
 Arg Tyr Leu Glu Ser Ser Val Val Leu Arg Arg Arg Val Pro Pro Met
         195                 200                 205

 gtg aat gtc acc cgc agc gag gcc tca gag ggc aac atc acc gtg aca      672
 Val Asn Val Thr Arg Ser Glu Ala Ser Glu Gly Asn Ile Thr Val Thr
     210                 215                 220

 tgc agg gct tcc agc ttc tat ccc cgg aat atc aca ctg acc tgg cgt      720
 Cys Arg Ala Ser Ser Phe Tyr Pro Arg Asn Ile Thr Leu Thr Trp Arg
 225                 230                 235                 240

 cag gat ggg gta tct ttg agc cac gac acc cag cag tgg ggg gat gtc      768
 Gln Asp Gly Val Ser Leu Ser His Asp Thr Gln Gln Trp Gly Asp Val
                 245                 250                 255

 ctg cct gat ggg aat gga acc tac cag acc tgg gtg gcc acc agg att      816
 Leu Pro Asp Gly Asn Gly Thr Tyr Gln Thr Trp Val Ala Thr Arg Ile
             260                 265                 270

 cgc caa gga gag gag cag agg ttc acc tgc tac atg gaa cac agc ggg      864
 Arg Gln Gly Glu Glu Gln Arg Phe Thr Cys Tyr Met Glu His Ser Gly
         275                 280                 285

 aat cac ggc act cac cct gtg ccc tct ggg aag gcg ctg gtg ctt cag      912
 Asn His Gly Thr His Pro Val Pro Ser Gly Lys Ala Leu Val Leu Gln
     290                 295                 300

 agt caa cgg aca gac ttt cca tat gtt tct gct gct atg cca tgt ttt      960
 Ser Gln Arg Thr Asp Phe Pro Tyr Val Ser Ala Ala Met Pro Cys Phe
 305                 310                 315                 320

 gtt att att att att ctc tgt gtc cct tgt tgc aag aag aaa aca tca     1008
 Val Ile Ile Ile Ile Leu Cys Val Pro Cys Cys Lys Lys Lys Thr Ser
                 325                 330                 335

 gcg gca gag ggt cca gag ctt gtg agc ctg cag gtc ctg gat caa cac     1056
 Ala Ala Glu Gly Pro Glu Leu Val Ser Leu Gln Val Leu Asp Gln His
             340                 345                 350

 cca gtt ggg aca gga gac cac agg gat gca gca cag ctg gga ttt cag     1104
 Pro Val Gly Thr Gly Asp His Arg Asp Ala Ala Gln Leu Gly Phe Gln
         355                 360                 365

 cct ctg atg tca gct act ggg tcc act ggt tcc act gag ggc gcc tag     1152
 Pro Leu Met Ser Ala Thr Gly Ser Thr Gly Ser Thr Glu Gly Ala 
     370                 375                 380





      <210> 161
      <211> 1329
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (587)..(1285)

      <400> 161
 ctgtggacct gaaggcaacc gaggagttag ccaggggcag ttctgtggta acaagaaaga     60

 ctcttggggg ctgtatgcct ccactgcctt ggcgcctctt gcctgcaatt gccgcgctgc    120

 ccctcgtgcc tcccttgatg ggcgttccgg ggtcgtcact gtcctctgcg cccctgggca    180

 ctggcagcgc gggccgggca gcggggaggg aggcgggaag cagagcggga ggcgccccgg    240

 gcttgcgcgc cgcggtgctc cacgagggat ttgccgcctt cagctgcagc agctgcagcg    300

 gcggcggcgg gaagaggggt ggagggtggt gaggagggcc ggagcccggg ccaggaggga    360

 gggaggggag ccgggaggct gtgccaggcg agccggaggg gtgctccgcg ctcccccgcc    420

 ctccttccgg gagcgaggat gcagactctg aaactggtgc tgctgggctg aggcggaggc    480

 aggggagttg cagcgcgcga ggctccgtga gtgtgtctcc tgcgcgctga gaggcggggg    540

 gaggcggagg accaggagga ggaggaggag gaggaggagg gggaga   atg ccc gga     595
                                                      Met Pro Gly
                                                        1

 gcc gcc gcc gct gcc gcc gcc gcc gcc gcc gcg atg ctc ccg gct cag      643
 Ala Ala Ala Ala Ala Ala Ala Ala Ala Ala Ala Met Leu Pro Ala Gln
       5                  10                  15

 gag gct gcc aag ctg tac cac acc aac tat gtg cgg aac tcg cgg gcc      691
 Glu Ala Ala Lys Leu Tyr His Thr Asn Tyr Val Arg Asn Ser Arg Ala
  20                  25                  30                  35

 atc ggc gtg ctg tgg gcc atc ttc acc atc tgc ttt gcc atc gtc aac      739
 Ile Gly Val Leu Trp Ala Ile Phe Thr Ile Cys Phe Ala Ile Val Asn
                  40                  45                  50

 gtg gtg tgc ttc atc cag ccc tac tgg ata ggc gac ggc gtg gac acc      787
 Val Val Cys Phe Ile Gln Pro Tyr Trp Ile Gly Asp Gly Val Asp Thr
              55                  60                  65

 ccg caa gcc ggc tat ttc ggg ctc ttc cac tac tgc atc ggc aac ggc      835
 Pro Gln Ala Gly Tyr Phe Gly Leu Phe His Tyr Cys Ile Gly Asn Gly
          70                  75                  80

 ttc tcc cgg gag ctg acc tgc agg ggc agc ttc acg gac ttc tcc acg      883
 Phe Ser Arg Glu Leu Thr Cys Arg Gly Ser Phe Thr Asp Phe Ser Thr
      85                  90                  95

 ctg ccc tcg ggc gcc ttc aaa gcc gcc tcc ttc ttt atc ggc ctc tcc      931
 Leu Pro Ser Gly Ala Phe Lys Ala Ala Ser Phe Phe Ile Gly Leu Ser
 100                 105                 110                 115

 atg atg ctc atc att gcc tgc atc att tgc ttt acc ctc ttc ttc ttc      979
 Met Met Leu Ile Ile Ala Cys Ile Ile Cys Phe Thr Leu Phe Phe Phe
                 120                 125                 130

 tgc aac acg gcc act gtg tac aag ata tgt gcc tgg atg cag ctc acc     1027
 Cys Asn Thr Ala Thr Val Tyr Lys Ile Cys Ala Trp Met Gln Leu Thr
             135                 140                 145

 tcc gct gcc tgc ctt gtg ctt ggc tgt atg att ttc cct gat ggc tgg     1075
 Ser Ala Ala Cys Leu Val Leu Gly Cys Met Ile Phe Pro Asp Gly Trp
         150                 155                 160

 gac tca gat gaa gta aaa cgg atg tgt gga gaa aag aca gac aag tac     1123
 Asp Ser Asp Glu Val Lys Arg Met Cys Gly Glu Lys Thr Asp Lys Tyr
     165                 170                 175

 act ctt ggg gct tgc tca gtc cgc tgg gca tac atc ctg gct att att     1171
 Thr Leu Gly Ala Cys Ser Val Arg Trp Ala Tyr Ile Leu Ala Ile Ile
 180                 185                 190                 195

 gga att ttg gat gcc ctg atc ctc tca ttt cta gca ttt gtg ctt ggt     1219
 Gly Ile Leu Asp Ala Leu Ile Leu Ser Phe Leu Ala Phe Val Leu Gly
                 200                 205                 210

 aat cga caa gac agc ttg atg gca gag gaa ctg aag gca gaa aac aaa     1267
 Asn Arg Gln Asp Ser Leu Met Ala Glu Glu Leu Lys Ala Glu Asn Lys
             215                 220                 225

 gat gat gga aat gct taa ggcaaa ctaaggtagt gtgagaccac accatgccgg     1321
 Asp Asp Gly Asn Ala 
         230

 gcgcggtg                                                            1329




      <210> 162
      <211> 3286
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (61)..(1788)

      <400> 162
 gccgcctccg gggcggccgt cgtcccggag cgccccgagc tggcgcggca tgggcgcggc     60
                                                                 
 atg agc gtg gag ccg ccg ccg gag ctg gag gag aag gcg gcg tcg gag      108
 Met Ser Val Glu Pro Pro Pro Glu Leu Glu Glu Lys Ala Ala Ser Glu
   1               5                  10                  15

 ccc gag gcg gga gcc atg ccg gag aag cgc gcg ggc gcg cag gcc gcg      156
 Pro Glu Ala Gly Ala Met Pro Glu Lys Arg Ala Gly Ala Gln Ala Ala
              20                  25                  30

 ggg agc acc tgg cta caa ggc ttt ggc cca cca agt gtg tac cat gct      204
 Gly Ser Thr Trp Leu Gln Gly Phe Gly Pro Pro Ser Val Tyr His Ala
          35                  40                  45

 gct att gtc atc ttc ctt gaa ttc ttt gcg tgg ggc ctt ttg aca act      252
 Ala Ile Val Ile Phe Leu Glu Phe Phe Ala Trp Gly Leu Leu Thr Thr
      50                  55                  60

 cca atg ttg act gtt cta cat gaa aca ttt tct caa cac aca ttc ctc      300
 Pro Met Leu Thr Val Leu His Glu Thr Phe Ser Gln His Thr Phe Leu
  65                  70                  75                  80

 atg aat ggt ctc att caa ggt gta aag cca ctg tgg ccc tcg gat ccc      348
 Met Asn Gly Leu Ile Gln Gly Val Lys Pro Leu Trp Pro Ser Asp Pro
                  85                  90                  95

 cct gga ctg gct aca aat aac aaa tac agc ctt tcc cac agg tgc agc      396
 Pro Gly Leu Ala Thr Asn Asn Lys Tyr Ser Leu Ser His Arg Cys Ser
             100                 105                 110

 ttc tgg ggc ttg gtc tac agt gtt cag aag gac aca ttg cgt aaa aaa      444
 Phe Trp Gly Leu Val Tyr Ser Val Gln Lys Asp Thr Leu Arg Lys Lys
         115                 120                 125

 aag ggc ctg ctc tct ttt ttg agt gcc cca ctc att ggt gcc ctg tct      492
 Lys Gly Leu Leu Ser Phe Leu Ser Ala Pro Leu Ile Gly Ala Leu Ser
     130                 135                 140

 gat gtg tgg ggg agg aag ccc ttt ctc ctc ggc act gta ttc ttt acc      540
 Asp Val Trp Gly Arg Lys Pro Phe Leu Leu Gly Thr Val Phe Phe Thr
 145                 150                 155                 160

 tgc ttc cca atc cca ctg atg agg atc agc cca tgg tgg tat ttt gcg      588
 Cys Phe Pro Ile Pro Leu Met Arg Ile Ser Pro Trp Trp Tyr Phe Ala
                 165                 170                 175

 atg att tct gtg tct gga gtc ttc tcg gtc acg ttt tct gtt ata ttt      636
 Met Ile Ser Val Ser Gly Val Phe Ser Val Thr Phe Ser Val Ile Phe
             180                 185                 190

 gcc tat gta gct gat gtc act cag gag cac gag cga agt aca gct tat      684
 Ala Tyr Val Ala Asp Val Thr Gln Glu His Glu Arg Ser Thr Ala Tyr
         195                 200                 205

 gga tgg gtc tcg gcc acg ttt gcg gct agt ctt gtc agc agc ccg gcc      732
 Gly Trp Val Ser Ala Thr Phe Ala Ala Ser Leu Val Ser Ser Pro Ala
     210                 215                 220

 att gga gca tat ctt tct gcc agt tac gga gac agc ctc gtt gtg ctg      780
 Ile Gly Ala Tyr Leu Ser Ala Ser Tyr Gly Asp Ser Leu Val Val Leu
 225                 230                 235                 240

 gtg gcc aca gtg gtg gct ctt ctg gac atc tgc ttc atc tta gtg gct      828
 Val Ala Thr Val Val Ala Leu Leu Asp Ile Cys Phe Ile Leu Val Ala
                 245                 250                 255

 gtt cca gaa tct ctg cct gag aaa atg aga ccg gtt tcc tgg gga gct      876
 Val Pro Glu Ser Leu Pro Glu Lys Met Arg Pro Val Ser Trp Gly Ala
             260                 265                 270

 cag att tct tgg aaa caa gca gac cct ttt gcg atc aaa ata atg aag      924
 Gln Ile Ser Trp Lys Gln Ala Asp Pro Phe Ala Ile Lys Ile Met Lys
         275                 280                 285

 ctg atg ttc cag aac att ggc aac att aat gtg tat tgg cat ttt aag      972
 Leu Met Phe Gln Asn Ile Gly Asn Ile Asn Val Tyr Trp His Phe Lys
     290                 295                 300

 tgt gtt ctt tct gct tat tct cag tcg ttg aag aaa gtt gga aaa gat     1020
 Cys Val Leu Ser Ala Tyr Ser Gln Ser Leu Lys Lys Val Gly Lys Asp
 305                 310                 315                 320

 tct act gtc tta cta atc tgc atc acc gtg ttt ctt tca tac ctt cct     1068
 Ser Thr Val Leu Leu Ile Cys Ile Thr Val Phe Leu Ser Tyr Leu Pro
                 325                 330                 335

 gaa gct gga cag tat tca agt ttt ttt ctc tat ctc agg cag gtc ata     1116
 Glu Ala Gly Gln Tyr Ser Ser Phe Phe Leu Tyr Leu Arg Gln Val Ile
             340                 345                 350

 ggt ttt gga tct gtt aaa att gca gca ttc ata gct atg gta gga att     1164
 Gly Phe Gly Ser Val Lys Ile Ala Ala Phe Ile Ala Met Val Gly Ile
         355                 360                 365

 ctg tct att gtg gct cag acg gcc ttt ctt agc atc ttg atg aga tca     1212
 Leu Ser Ile Val Ala Gln Thr Ala Phe Leu Ser Ile Leu Met Arg Ser
     370                 375                 380

 tta gga aat aag aat act gtc ctc ctt ggc ttg ggc ttc cag atg ctc     1260
 Leu Gly Asn Lys Asn Thr Val Leu Leu Gly Leu Gly Phe Gln Met Leu
 385                 390                 395                 400

 cag tta gcc tgg tac ggt ttt gga tca cag gcc tgg atg atg tgg gca     1308
 Gln Leu Ala Trp Tyr Gly Phe Gly Ser Gln Ala Trp Met Met Trp Ala
                 405                 410                 415

 gca ggg acc gtg gct gcc atg tcc agc atc acg ttt ccg gca atc agt     1356
 Ala Gly Thr Val Ala Ala Met Ser Ser Ile Thr Phe Pro Ala Ile Ser
             420                 425                 430

 gcc ctc gtc tct cgg aat gca gag tca gat cag caa gga gtt gcc cag     1404
 Ala Leu Val Ser Arg Asn Ala Glu Ser Asp Gln Gln Gly Val Ala Gln
         435                 440                 445

 ggg atc ata act gga ata aga gga cta tgc aat ggc ctg ggg cca gca     1452
 Gly Ile Ile Thr Gly Ile Arg Gly Leu Cys Asn Gly Leu Gly Pro Ala
     450                 455                 460

 ctg tat ggc ttc ata ttc tac atg ttc cat gtg gaa ctg act gag ttg     1500
 Leu Tyr Gly Phe Ile Phe Tyr Met Phe His Val Glu Leu Thr Glu Leu
 465                 470                 475                 480

 ggc ccg aaa ttg aat tct aac aac gtt ccc ctg cag gga gct gtc atc     1548
 Gly Pro Lys Leu Asn Ser Asn Asn Val Pro Leu Gln Gly Ala Val Ile
                 485                 490                 495

 cca ggc ccg ccg ttt tta ttt ggg gca tgt ata gtc ctt atg tct ttt     1596
 Pro Gly Pro Pro Phe Leu Phe Gly Ala Cys Ile Val Leu Met Ser Phe
             500                 505                 510

 ctg gtt gcc tta ttc att cct gaa tac agt aaa gcc agt gga gtt caa     1644
 Leu Val Ala Leu Phe Ile Pro Glu Tyr Ser Lys Ala Ser Gly Val Gln
         515                 520                 525

 aaa cac agt aac agc agc agc ggc agc ctg acc aac acc cca gaa cgg     1692
 Lys His Ser Asn Ser Ser Ser Gly Ser Leu Thr Asn Thr Pro Glu Arg
     530                 535                 540

 ggc agt gat gag gac att gag cca cta ctg caa gac agc agc atc tgg     1740
 Gly Ser Asp Glu Asp Ile Glu Pro Leu Leu Gln Asp Ser Ser Ile Trp
 545                 550                 555                 560

 gag ctc tct tca ttt gag gag cct ggg aat cag tgc act gag ctg taa     1788
 Glu Leu Ser Ser Phe Glu Glu Pro Gly Asn Gln Cys Thr Glu Leu 
                 565                 570                 575

 actcggcaga aagtgggatt ctgcatacgc catctctgag agccatggag ggagccacac   1848

 ccctggtgac ttcatggtgc tggatgggag acgctagcgg catccttcag ggccaagttt   1908

 gataaatacc accgccatca ttctgctcat cctcctcctg tttttttttt tctcttacat   1968

 tctttttttt tttcctgttt atacattaga acaagataag atttgaaata cttccttgca   2028

 aataatgtgc aactcccaag gtgaaactca aatagaaaaa gtcatctctc tggtagaaag   2088

 gatggctttc ctgtaatgac tatagagtaa gagtggcagc aatctttcca tgcccttttc   2148

 agcagaaggc acagaacagt agcgggactg ccatctctgg caagatttca ggtaaagaat   2208

 ctcttcttaa tttctacctt cctgtttctc tgaatcagcc cataggtgtt gatgagtggc   2268

 cactcttaaa gagtcactca gtatcaggga tctactgtct ttgttcaaag gtcaaataaa   2328

 aacctagtct ccttttattc tactttctat tcttagctag aatgaaactc agcatatata   2388

 cacttctgga cataataata ttgaatagta attaccttta ctagatgaaa gaaattttca   2448

 ttacaaactt aaatcatgta aaactcaaca actcagattc ctggacctgg tgtcctggtt   2508

 gggtccaagg tgattttaca gaagaaaaaa acaactcaag cattctggtg gcaacataga   2568

 gattgtaggc tgcttctaag aaagttatta acaatttgga aattcctaag taggatgaga   2628

 gttagtaact ggatacgagt gaagtttata tccaagttca gactcaaagg cattattatg   2688

 atttgcttct tcccatgtct tccatgtcct gcttctcaaa gtttttctca tccatcacac   2748

 tcctgcctta actgctctga gtatgcattt gttttcaatt catctttatt tcaatctgtt   2808

 taacttttga atcgcatggg aatacgcaca ttaagttcct ttctaaaata aggttttatg   2868

 aagctgagtt tcacgataag tgtcttgcta ttttttgaga tgttttatgg acaaagaaaa   2928

 ctttacagat ttatatgtat tttgctgcac cagtaaatgg accattaact agggcccacc   2988

 tttaacagag cacccctttg aaagttttat aggtatgaaa tatatgtaga tatttgtaaa   3048

 gggttttaat tttttttttg atggggtgct gtgtaaatct tgtatttata aatgtaatga   3108

 aggtattgac agaaaaaaat atatacaact tttataaagg attgtgtact gactgaatac   3168

 atttaaaaga aaatatattt tgaaacctgt tctgctatga acagagataa catatctttt   3228

 tactatgcta ttggttttta ggttaagctt cctaatgcat aataaattta cagtggtt     3286




      <210> 163
      <211> 3490
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (1)..(1992)

      <400> 163
  atg aag agg aca agc tgt ccc agt agg ccc cgg act gcc ctg gtt tta      48
  Met Lys Arg Thr Ser Cys Pro Ser Arg Pro Arg Thr Ala Leu Val Leu
    1               5                  10                  15

 aca cta aat gtc cga cat cct gat aac cct tac tcc cag gca aat cag       96
 Thr Leu Asn Val Arg His Pro Asp Asn Pro Tyr Ser Gln Ala Asn Gln
              20                  25                  30

 gcc agt tgg tca tct aat tgg agg tta tca aag gag ccc tcg gcg ccg      144
 Ala Ser Trp Ser Ser Asn Trp Arg Leu Ser Lys Glu Pro Ser Ala Pro
          35                  40                  45

 ccg cct gac ccg cag gcc gcc gcg ggc cgc aga gcc cat gag ggc gcg      192
 Pro Pro Asp Pro Gln Ala Ala Ala Gly Arg Arg Ala His Glu Gly Ala
      50                  55                  60

 ggc acc gcc gcc gcc tcc gcg gcg tcg ccg tcg tcc cgg agc gcc ccg      240
 Gly Thr Ala Ala Ala Ser Ala Ala Ser Pro Ser Ser Arg Ser Ala Pro
  65                  70                  75                  80

 agc tgg cgc ggg cat ggc cgc ggc atg agc gtg gag ccg ccg ccg gag      288
 Ser Trp Arg Gly His Gly Arg Gly Met Ser Val Glu Pro Pro Pro Glu
                  85                  90                  95

 ctg gag gag aag gcg gcg tcg gag ccc gag gcg gga gcc atg ccg gag      336
 Leu Glu Glu Lys Ala Ala Ser Glu Pro Glu Ala Gly Ala Met Pro Glu
             100                 105                 110

 aag cgc gcg ggc gcg cag gcc gcg ggg agc acc tgg cta caa ggc ttt      384
 Lys Arg Ala Gly Ala Gln Ala Ala Gly Ser Thr Trp Leu Gln Gly Phe
         115                 120                 125

 ggc cca cca agt gtg tac cat gct gct att gtc atc ttc ctt gaa ttc      432
 Gly Pro Pro Ser Val Tyr His Ala Ala Ile Val Ile Phe Leu Glu Phe
     130                 135                 140

 ttt gcg tgg ggc ctt ttg aca act cca atg ttg act gtt cta cat gaa      480
 Phe Ala Trp Gly Leu Leu Thr Thr Pro Met Leu Thr Val Leu His Glu
 145                 150                 155                 160

 aca ttt tct caa cac aca ttc ctc atg aat ggt ctc att caa ggt gta      528
 Thr Phe Ser Gln His Thr Phe Leu Met Asn Gly Leu Ile Gln Gly Val
                 165                 170                 175

 aag cca ctg tgg ccc tcg gat ccc cct gga ctg gct aca aat aac aaa      576
 Lys Pro Leu Trp Pro Ser Asp Pro Pro Gly Leu Ala Thr Asn Asn Lys
             180                 185                 190

 tac agc ctt tcc cac agg tgc agc ttc tgg ggc ttg gtc tac agt gtt      624
 Tyr Ser Leu Ser His Arg Cys Ser Phe Trp Gly Leu Val Tyr Ser Val
         195                 200                 205

 cag aag gac aca ttg cgt aaa aaa aag ggc ctg ctc tct ttt ttg agt      672
 Gln Lys Asp Thr Leu Arg Lys Lys Lys Gly Leu Leu Ser Phe Leu Ser
     210                 215                 220

 gcc cca ctc att ggt gcc ctg tct gat gtg tgg ggg agg aag ccc ttt      720
 Ala Pro Leu Ile Gly Ala Leu Ser Asp Val Trp Gly Arg Lys Pro Phe
 225                 230                 235                 240

 ctc ctc ggc act gta ttc ttt acc tgc ttc cca atc cca ctg atg agg      768
 Leu Leu Gly Thr Val Phe Phe Thr Cys Phe Pro Ile Pro Leu Met Arg
                 245                 250                 255

 atc agc cca tgg tgg tat ttt gcg atg att tct gtg tct gga gtc ttc      816
 Ile Ser Pro Trp Trp Tyr Phe Ala Met Ile Ser Val Ser Gly Val Phe
             260                 265                 270

 tcg gtc acg ttt tct gtt ata ttt gcc tat gta gct gat gtc act cag      864
 Ser Val Thr Phe Ser Val Ile Phe Ala Tyr Val Ala Asp Val Thr Gln
         275                 280                 285

 gag cac gag cga agt aca gct tat gga tgg gtc tcg gcc acg ttt gcg      912
 Glu His Glu Arg Ser Thr Ala Tyr Gly Trp Val Ser Ala Thr Phe Ala
     290                 295                 300

 gct agt ctt gtc agc agc ccg gcc att gga gca tat ctt tct gcc agt      960
 Ala Ser Leu Val Ser Ser Pro Ala Ile Gly Ala Tyr Leu Ser Ala Ser
 305                 310                 315                 320

 tac gga gac agc ctc gtt gtg ctg gtg gcc aca gtg gtg gct ctt ctg     1008
 Tyr Gly Asp Ser Leu Val Val Leu Val Ala Thr Val Val Ala Leu Leu
                 325                 330                 335

 gac atc tgc ttc atc tta gtg gct gtt cca gaa tct ctg cct gag aaa     1056
 Asp Ile Cys Phe Ile Leu Val Ala Val Pro Glu Ser Leu Pro Glu Lys
             340                 345                 350

 atg aga ccg gtt tcc tgg gga gct cag att tct tgg aaa caa gca gac     1104
 Met Arg Pro Val Ser Trp Gly Ala Gln Ile Ser Trp Lys Gln Ala Asp
         355                 360                 365

 cct ttt gcg atc aaa ata atg aag ctg atg ttc cag aac att ggc aac     1152
 Pro Phe Ala Ile Lys Ile Met Lys Leu Met Phe Gln Asn Ile Gly Asn
     370                 375                 380

 att aat gtg tat tgg cat ttt aag tgt gtt ctt tct gct tat tct cag     1200
 Ile Asn Val Tyr Trp His Phe Lys Cys Val Leu Ser Ala Tyr Ser Gln
 385                 390                 395                 400

 tcg ttg aag aaa gtt gga aaa gat tct act gtc tta cta atc tgc atc     1248
 Ser Leu Lys Lys Val Gly Lys Asp Ser Thr Val Leu Leu Ile Cys Ile
                 405                 410                 415

 acc gtg ttt ctt tca tac ctt cct gaa gct gga cag tat tca agt ttt     1296
 Thr Val Phe Leu Ser Tyr Leu Pro Glu Ala Gly Gln Tyr Ser Ser Phe
             420                 425                 430

 ttt ctc tat ctc agg cag gtc ata ggt ttt gga tct gtt aaa att gca     1344
 Phe Leu Tyr Leu Arg Gln Val Ile Gly Phe Gly Ser Val Lys Ile Ala
         435                 440                 445

 gca ttc ata gct atg gta gga att ctg tct att gtg gct cag acg gcc     1392
 Ala Phe Ile Ala Met Val Gly Ile Leu Ser Ile Val Ala Gln Thr Ala
     450                 455                 460

 ttt ctt agc atc ttg atg aga tca tta gga aat aag aat act gtc ctc     1440
 Phe Leu Ser Ile Leu Met Arg Ser Leu Gly Asn Lys Asn Thr Val Leu
 465                 470                 475                 480

 ctt ggc ttg ggc ttc cag atg ctc cag tta gcc tgg tac ggt ttt gga     1488
 Leu Gly Leu Gly Phe Gln Met Leu Gln Leu Ala Trp Tyr Gly Phe Gly
                 485                 490                 495

 tca cag gcc tgg atg atg tgg gca gca ggg acc gtg gct gcc atg tcc     1536
 Ser Gln Ala Trp Met Met Trp Ala Ala Gly Thr Val Ala Ala Met Ser
             500                 505                 510

 agc atc acg ttt ccg gca atc agt gcc ctc gtc tct cgg aat gca gag     1584
 Ser Ile Thr Phe Pro Ala Ile Ser Ala Leu Val Ser Arg Asn Ala Glu
         515                 520                 525

 tca gat cag caa gga gtt gcc cag ggg atc ata act gga ata aga gga     1632
 Ser Asp Gln Gln Gly Val Ala Gln Gly Ile Ile Thr Gly Ile Arg Gly
     530                 535                 540

 cta tgc aat ggc ctg ggg cca gca ctg tat ggc ttc ata ttc tac atg     1680
 Leu Cys Asn Gly Leu Gly Pro Ala Leu Tyr Gly Phe Ile Phe Tyr Met
 545                 550                 555                 560

 ttc cat gtg gaa ctg act gag ttg ggc ccg aaa ttg aat tct aac aac     1728
 Phe His Val Glu Leu Thr Glu Leu Gly Pro Lys Leu Asn Ser Asn Asn
                 565                 570                 575

 gtt ccc ctg cag gga gct gtc atc cca ggc ccg ccg ttt tta ttt ggg     1776
 Val Pro Leu Gln Gly Ala Val Ile Pro Gly Pro Pro Phe Leu Phe Gly
             580                 585                 590

 gca tgt ata gtc ctt atg tct ttt ctg gtt gcc tta ttc att cct gaa     1824
 Ala Cys Ile Val Leu Met Ser Phe Leu Val Ala Leu Phe Ile Pro Glu
         595                 600                 605

 tac agt aaa gcc agt gga gtt caa aaa cac agt aac agc agc agc ggc     1872
 Tyr Ser Lys Ala Ser Gly Val Gln Lys His Ser Asn Ser Ser Ser Gly
     610                 615                 620

 agc ctg acc aac acc cca gaa cgg ggc agt gat gag gac att gag cca     1920
 Ser Leu Thr Asn Thr Pro Glu Arg Gly Ser Asp Glu Asp Ile Glu Pro
 625                 630                 635                 640

 cta ctg caa gac agc agc atc tgg gag ctc tct tca ttt gag gag cct     1968
 Leu Leu Gln Asp Ser Ser Ile Trp Glu Leu Ser Ser Phe Glu Glu Pro
                 645                 650                 655

 ggg aat cag tgc act gag ctg taa actcggcaga aagtgggatt ctgcatacgc    2022
 Gly Asn Gln Cys Thr Glu Leu 
             660

 catctctgag agccatggag ggagccacac ccctggtgac ttcatggtgc tggatgggag   2082

 acgctagcgg catccttcag ggccaagttt gataaatacc accgccatca ttctgctcat   2142

 cctcctcctg tttttttttt tctcttacat tctttttttt tttcctgttt atacattaga   2202

 acaagataag atttgaaata cttccttgca aataatgtgc aactcccaag gtgaaactca   2262

 aatagaaaaa gtcatctctc tggtagaaag gatggctttc ctgtaatgac tatagagtaa   2322

 gagtggcagc aatctttcca tgcccttttc agcagaaggc acagaacagt agcgggactg   2382

 ccatctctgg caagatttca ggtaaagaat ctcttcttaa tttctacctt cctgtttctc   2442

 tgaatcagcc cataggtgtt gatgagtggc cactcttaaa gagtcactca gtatcaggga   2502

 tctactgtct ttgttcaaag gtcaaataaa aacctagtct ccttttattc tactttctat   2562

 tcttagctag aatgaaactc agcatatata cacttctgga cataataata ttgaatagta   2622

 attaccttta ctagatgaaa gaaattttca ttacaaactt aaatcatgta aaactcaaca   2682

 actcagattc ctggacctgg tgtcctggtt gggtccaagg tgattttaca gaagaaaaaa   2742

 acaactcaag cattctggtg gcaacataga gattgtaggc tgcttctaag aaagttatta   2802

 acaatttgga aattcctaag taggatgaga gttagtaact ggatacgagt gaagtttata   2862

 tccaagttca gactcaaagg cattattatg atttgcttct tcccatgtct tccatgtcct   2922

 gcttctcaaa gtttttctca tccatcacac tcctgcctta actgctctga gtatgcattt   2982

 gttttcaatt catctttatt tcaatctgtt taacttttga atcgcatggg aatacgcaca   3042

 ttaagttcct ttctaaaata aggttttatg aagctgagtt tcacgataag tgtcttgcta   3102

 ttttttgaga tgttttatgg acaaagaaaa ctttacagat ttatatgtat tttgctgcac   3162

 cagtaaatgg accattaact agggcccacc tttaacagag cacccctttg aaagttttat   3222

 aggtatgaaa tatatgtaga tatttgtaaa gggttttaat tttttttttg atggggtgct   3282

 gtgtaaatct tgtatttata aatgtaatga aggtattgac agaaaaaaat atatacaact   3342

 tttataaagg attgtgtact gactgaatac atttaaaaga aaatatattt tgaaacctgt   3402

 tctgctatga acagagataa catatctttt tactatgcta ttggttttta ggttaagctt   3462

 cctaatgcat aataaattta cagtggtt                                      3490




      <210> 164
      <211> 2463
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (244)..(2463)

      <400> 164
 ggcgcgcgag agctgctagg gcggtttctc tgcctcgggc ctgttgggca gggccggcta     60

 aggtgcgcgt gctcgctggt tctaaccctt ctgttgggcg tttctgctga gaggcgggag    120

 gcgccgagag tctgtgcgaa ggtccgtgga cagactgctt tgcctgttgt tgctcttcgg    180

 aggcggcgat ccccgaaggc gagctgaaat acggctgcag gctacaattt gcagccgacc    240

 att  atg gat gac aag gag ccg aag agg tgg ccc acc ctc agg gac cgc     288
      Met Asp Asp Lys Glu Pro Lys Arg Trp Pro Thr Leu Arg Asp Arg
        1               5                  10                  15

 ttg tgc tcg gat ggc ttc tta ttt ccc caa tac ccc att aaa ccg tat      336
 Leu Cys Ser Asp Gly Phe Leu Phe Pro Gln Tyr Pro Ile Lys Pro Tyr
                  20                  25                  30

 cat ctg aag ggg atc cac aga gct gtc ttc tat cgt gat ctg gag gaa      384
 His Leu Lys Gly Ile His Arg Ala Val Phe Tyr Arg Asp Leu Glu Glu
              35                  40                  45

 ctg aag ttc gtt ctg ctc acg cgt tat gac atc aat aag aga gac agg      432
 Leu Lys Phe Val Leu Leu Thr Arg Tyr Asp Ile Asn Lys Arg Asp Arg
          50                  55                  60

 aag gaa agg acc gcc cta cat ttg gcc tgt gcc act ggc caa ccg gaa      480
 Lys Glu Arg Thr Ala Leu His Leu Ala Cys Ala Thr Gly Gln Pro Glu
      65                  70                  75

 atg gta cat ctc ctg gtg tcc aga aga tgt gag ctt aac ctc tgc gac      528
 Met Val His Leu Leu Val Ser Arg Arg Cys Glu Leu Asn Leu Cys Asp
  80                  85                  90                  95

 cgt gaa gac agg aca cct ctg atc aag gct gta caa ctg agg cag gag      576
 Arg Glu Asp Arg Thr Pro Leu Ile Lys Ala Val Gln Leu Arg Gln Glu
                 100                 105                 110

 gct tgt gca act ctt ctg ctg caa aat ggc gcc gat cca aat att acg      624
 Ala Cys Ala Thr Leu Leu Leu Gln Asn Gly Ala Asp Pro Asn Ile Thr
             115                 120                 125

 gat gtc ttt gga agg act gct ctg cac tac gct gtg tat aat gaa gat      672
 Asp Val Phe Gly Arg Thr Ala Leu His Tyr Ala Val Tyr Asn Glu Asp
         130                 135                 140

 aca tcc atg ata gaa aaa ctt ctt tca cat ggt aca aat att gaa gaa      720
 Thr Ser Met Ile Glu Lys Leu Leu Ser His Gly Thr Asn Ile Glu Glu
     145                 150                 155

 tgc agc aag aat gaa tat cag cca ctg tta ctt gct gtg agt cga aga      768
 Cys Ser Lys Asn Glu Tyr Gln Pro Leu Leu Leu Ala Val Ser Arg Arg
 160                 165                 170                 175

 aaa gtg aaa atg gtg gaa ttt tta tta aag aaa aaa gca aat gta aat      816
 Lys Val Lys Met Val Glu Phe Leu Leu Lys Lys Lys Ala Asn Val Asn
                 180                 185                 190

 gcc att gat tat ctt ggc aga tca gcc ctc ata ctt gct gtt act ctt      864
 Ala Ile Asp Tyr Leu Gly Arg Ser Ala Leu Ile Leu Ala Val Thr Leu
             195                 200                 205

 gga gaa aaa gat ata gtc att ctt ctt ctg cag cac aat att gat gtg      912
 Gly Glu Lys Asp Ile Val Ile Leu Leu Leu Gln His Asn Ile Asp Val
         210                 215                 220

 ttt tct cga gat gtg tat gga aag ctt gca gaa gat tat gcc aaa aga      960
 Phe Ser Arg Asp Val Tyr Gly Lys Leu Ala Glu Asp Tyr Ala Lys Arg
     225                 230                 235

 aga tca tct gct tca cgt gat ctt gga tcc gtg aac cat gat gat att     1008
 Arg Ser Ser Ala Ser Arg Asp Leu Gly Ser Val Asn His Asp Asp Ile
 240                 245                 250                 255

 gtt ggt tgg atg tta gtg tct cct cag aaa caa cga gct gag aag gct     1056
 Val Gly Trp Met Leu Val Ser Pro Gln Lys Gln Arg Ala Glu Lys Ala
                 260                 265                 270

 aca agt gac gac aaa gat tct gtt tca aat ata gcc aca gaa ata aag     1104
 Thr Ser Asp Asp Lys Asp Ser Val Ser Asn Ile Ala Thr Glu Ile Lys
             275                 280                 285

 gag gga cct ata tct ggg aca gat cac ctt tca gag gag aag aat ttt     1152
 Glu Gly Pro Ile Ser Gly Thr Asp His Leu Ser Glu Glu Lys Asn Phe
         290                 295                 300

 aaa gaa tcc tgt ctg ttc gac agg gat tta aga gag cag tta act act     1200
 Lys Glu Ser Cys Leu Phe Asp Arg Asp Leu Arg Glu Gln Leu Thr Thr
     305                 310                 315

 ata gat aaa gaa aca ctt caa gga gca gct aaa cca gat gct cac ttt     1248
 Ile Asp Lys Glu Thr Leu Gln Gly Ala Ala Lys Pro Asp Ala His Phe
 320                 325                 330                 335

 agg act atg ccc tgc ggg cag ctt ctg cac ttc ctg cag agg aac acc     1296
 Arg Thr Met Pro Cys Gly Gln Leu Leu His Phe Leu Gln Arg Asn Thr
                 340                 345                 350

 atc atc gcc gcc gtc tca ggg gtg gcc atc ctc atg gcc atc gtg ctg     1344
 Ile Ile Ala Ala Val Ser Gly Val Ala Ile Leu Met Ala Ile Val Leu
             355                 360                 365

 ttg ctg ctt ggg ttg gcc tca tac atc agg aag aaa cag cca tcc ctg     1392
 Leu Leu Leu Gly Leu Ala Ser Tyr Ile Arg Lys Lys Gln Pro Ser Leu
         370                 375                 380

 caa tac tgg aga gct gcc cct gga ggg cgc aag gga atc ccg ttg ctg     1440
 Gln Tyr Trp Arg Ala Ala Pro Gly Gly Arg Lys Gly Ile Pro Leu Leu
     385                 390                 395

 cac tcg gac gcg cag tca cta gac atg aga gat gac ggt ggt ggt agc     1488
 His Ser Asp Ala Gln Ser Leu Asp Met Arg Asp Asp Gly Gly Gly Ser
 400                 405                 410                 415

 agt aat gga gca ttt gcc ttt agg cct ctt tta act ttc aca aca gcc     1536
 Ser Asn Gly Ala Phe Ala Phe Arg Pro Leu Leu Thr Phe Thr Thr Ala
                 420                 425                 430

 tac aag aca gca gtg gct tgt gtt ctc tta act gtg cag cca gat tgg     1584
 Tyr Lys Thr Ala Val Ala Cys Val Leu Leu Thr Val Gln Pro Asp Trp
             435                 440                 445

 acc tgc tca gct cca ggt gaa atg gac aga aag ccc atc cct gcc cgg     1632
 Thr Cys Ser Ala Pro Gly Glu Met Asp Arg Lys Pro Ile Pro Ala Arg
         450                 455                 460

 tct gag gat tgg gaa gcc ttc ctg gag gaa aac acg ctt aat tgg aga     1680
 Ser Glu Asp Trp Glu Ala Phe Leu Glu Glu Asn Thr Leu Asn Trp Arg
     465                 470                 475

 cct gaa aga gga cta gga aat agg cag ccc cct ttc ctg tct tcg cat     1728
 Pro Glu Arg Gly Leu Gly Asn Arg Gln Pro Pro Phe Leu Ser Ser His
 480                 485                 490                 495

 cca gga aat agg tta gtt tca gac aag cct gct tgc cgg agc tca gca     1776
 Pro Gly Asn Arg Leu Val Ser Asp Lys Pro Ala Cys Arg Ser Ser Ala
                 500                 505                 510

 gac acc agg cct tcc ggg cag gcc tgg ccc acc gtg ggc ctc aga gct     1824
 Asp Thr Arg Pro Ser Gly Gln Ala Trp Pro Thr Val Gly Leu Arg Ala
             515                 520                 525

 gct gct ggg gca ttc agg gaa atc caa acc ggc ttt gta agc ccc gat     1872
 Ala Ala Gly Ala Phe Arg Glu Ile Gln Thr Gly Phe Val Ser Pro Asp
         530                 535                 540

 tcc tca ccc aga acc ggc tct cca ttg gca ttg gga cca gag acc ccg     1920
 Ser Ser Pro Arg Thr Gly Ser Pro Leu Ala Leu Gly Pro Glu Thr Pro
     545                 550                 555

 caa gtg gcc tgt ttg cct gga cat cca cct gta cgt ccc cag ggc tct     1968
 Gln Val Ala Cys Leu Pro Gly His Pro Pro Val Arg Pro Gln Gly Ser
 560                 565                 570                 575

 cgg gag gat aaa gag agt gac tgt atc cac act gcc cgg cac ata cag     2016
 Arg Glu Asp Lys Glu Ser Asp Cys Ile His Thr Ala Arg His Ile Gln
                 580                 585                 590

 gtg ctg cag aaa ggt ctc act aaa acc ctc att atc ctc act agc tct     2064
 Val Leu Gln Lys Gly Leu Thr Lys Thr Leu Ile Ile Leu Thr Ser Ser
             595                 600                 605

 ggg tgg cct cgg gct ctg gac tcc aca gtt cct gta tgc tct ccg ggg     2112
 Gly Trp Pro Arg Ala Leu Asp Ser Thr Val Pro Val Cys Ser Pro Gly
         610                 615                 620

 ctg cag cac cca gac cac ccc gtg ctg acc act ccc tgc ccc acc cca     2160
 Leu Gln His Pro Asp His Pro Val Leu Thr Thr Pro Cys Pro Thr Pro
     625                 630                 635

 agg tgt cag gtt cca ccg gtg ctc aga ggc atc ccc acc cat ccc agt     2208
 Arg Cys Gln Val Pro Pro Val Leu Arg Gly Ile Pro Thr His Pro Ser
 640                 645                 650                 655

 gga ctg cag acc ttt gta ggt acc tgg tat att gag cac ctc ctc tgt     2256
 Gly Leu Gln Thr Phe Val Gly Thr Trp Tyr Ile Glu His Leu Leu Cys
                 660                 665                 670

 gcc atg ctg ggc ctg ggc tgt gag tgt ggg gca ggt gcc ccg tgg ctg     2304
 Ala Met Leu Gly Leu Gly Cys Glu Cys Gly Ala Gly Ala Pro Trp Leu
             675                 680                 685

 ctc tgc tgt gat ctc tgt gct gtg atc cag ggg ctt tgt gtg tgg aat     2352
 Leu Cys Cys Asp Leu Cys Ala Val Ile Gln Gly Leu Cys Val Trp Asn
         690                 695                 700

 cac aca att cgt agc cct tgg aac ctg gtt tct ttc atc cag cct gag     2400
 His Thr Ile Arg Ser Pro Trp Asn Leu Val Ser Phe Ile Gln Pro Glu
     705                 710                 715

 gcc ttt gcg atg cgt ttg cgg aac tgc gtg tct ccg tat gct gtt cca     2448
 Ala Phe Ala Met Arg Leu Arg Asn Cys Val Ser Pro Tyr Ala Val Pro
 720                 725                 730                 735

 ctt acc gcg gag tag                                                 2463
 Leu Thr Ala Glu 






      <210> 165
      <211> 2252
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (57)..(1277)

      <400> 165
 gaggtggagg cagcagggag aaagcaaaac aatcaggatc caacttgata agtggg         56                                                                 
 atg gaa gct gta gga att tgg agg aaa gag ttg ctc caa cca cag acg      104
 Met Glu Ala Val Gly Ile Trp Arg Lys Glu Leu Leu Gln Pro Gln Thr
   1               5                  10                  15

 gaa gga aaa gct ctc agg gaa ggg aca gat cca gtg aga atg cat ttt      152
 Glu Gly Lys Ala Leu Arg Glu Gly Thr Asp Pro Val Arg Met His Phe
              20                  25                  30

 cct agt gtc aga ggt cct ccc ttc ctg cca gtg tca ggg aag agg agg      200
 Pro Ser Val Arg Gly Pro Pro Phe Leu Pro Val Ser Gly Lys Arg Arg
          35                  40                  45

 cta gtt aaa gtc agt aga cct cgg tgt tta aaa ctc agg aca aga cag      248
 Leu Val Lys Val Ser Arg Pro Arg Cys Leu Lys Leu Arg Thr Arg Gln
      50                  55                  60

 aaa tgt tct agt tat ttc aaa aac ttt cga tac tgc tcc tat gct ccc      296
 Lys Cys Ser Ser Tyr Phe Lys Asn Phe Arg Tyr Cys Ser Tyr Ala Pro
  65                  70                  75                  80

 cat gtc cga ata tgt atg ccc ttg acg gac ggc att tct tca ttt gag      344
 His Val Arg Ile Cys Met Pro Leu Thr Asp Gly Ile Ser Ser Phe Glu
                  85                  90                  95

 gac ctc ttg gct aac aat atc ctc aga ata ttt gtc tgg gtt ata gct      392
 Asp Leu Leu Ala Asn Asn Ile Leu Arg Ile Phe Val Trp Val Ile Ala
             100                 105                 110

 ttc att acc tgc ttt gga aat ctt ttt gtc att ggc atg aga tct ttc      440
 Phe Ile Thr Cys Phe Gly Asn Leu Phe Val Ile Gly Met Arg Ser Phe
         115                 120                 125

 att aaa gct gaa aat aca act cac gct atg tcc atc aaa atc ctt tgt      488
 Ile Lys Ala Glu Asn Thr Thr His Ala Met Ser Ile Lys Ile Leu Cys
     130                 135                 140

 tgt gct gat tgc ctg atg ggt gtt tac ttg ttc ttt gtt ggc att ttc      536
 Cys Ala Asp Cys Leu Met Gly Val Tyr Leu Phe Phe Val Gly Ile Phe
 145                 150                 155                 160

 gat ata aaa tac cga ggg cag tat cag aag tat gcc ttg ctg tgg atg      584
 Asp Ile Lys Tyr Arg Gly Gln Tyr Gln Lys Tyr Ala Leu Leu Trp Met
                 165                 170                 175

 gag agc gtg cag tgc cgc ctc atg ggg ttc ctg gcc atg ctg tcc acc      632
 Glu Ser Val Gln Cys Arg Leu Met Gly Phe Leu Ala Met Leu Ser Thr
             180                 185                 190

 gaa gtc tct gtt ctg cta ctg acc tac ttg act ttg gag aag ttc ctg      680
 Glu Val Ser Val Leu Leu Leu Thr Tyr Leu Thr Leu Glu Lys Phe Leu
         195                 200                 205

 gtc att gtc ttc ccc ttc agt aac att cga cct gga aaa cgg cag acc      728
 Val Ile Val Phe Pro Phe Ser Asn Ile Arg Pro Gly Lys Arg Gln Thr
     210                 215                 220

 tca gtc atc ctc att tgc atc tgg atg gcg gga ttt tta ata gct gta      776
 Ser Val Ile Leu Ile Cys Ile Trp Met Ala Gly Phe Leu Ile Ala Val
 225                 230                 235                 240

 att cca ttt tgg aat aag gat tat ttt gga aac ttt tat ggg aaa aat      824
 Ile Pro Phe Trp Asn Lys Asp Tyr Phe Gly Asn Phe Tyr Gly Lys Asn
                 245                 250                 255

 gga gta tgt ttc cca ctt tat tat gac caa aca gaa gat att gga agc      872
 Gly Val Cys Phe Pro Leu Tyr Tyr Asp Gln Thr Glu Asp Ile Gly Ser
             260                 265                 270

 aaa ggg tat tct ctt gga att ttc cta ggt gtg aac ttg ctg gct ttt      920
 Lys Gly Tyr Ser Leu Gly Ile Phe Leu Gly Val Asn Leu Leu Ala Phe
         275                 280                 285

 ctc atc att gtg ttt tcc tat att act atg ttc tgt tcc att caa aaa      968
 Leu Ile Ile Val Phe Ser Tyr Ile Thr Met Phe Cys Ser Ile Gln Lys
     290                 295                 300

 acc gcc ttg cag acc aca gaa gta agg aat tgt ttt gga aga gag gtg     1016
 Thr Ala Leu Gln Thr Thr Glu Val Arg Asn Cys Phe Gly Arg Glu Val
 305                 310                 315                 320

 gct gtt gca aat cgt ttc ttt ttt ata gtg ttc tct gat gcc atc tgc     1064
 Ala Val Ala Asn Arg Phe Phe Phe Ile Val Phe Ser Asp Ala Ile Cys
                 325                 330                 335

 tgg att cct gta ttt gta gtt aaa atc ctt tcc ctc ttc cgg gtg gaa     1112
 Trp Ile Pro Val Phe Val Val Lys Ile Leu Ser Leu Phe Arg Val Glu
             340                 345                 350

 ata cca ggt cag tct ctt cta tca ttc cca agt ata ata cat cgt gcc     1160
 Ile Pro Gly Gln Ser Leu Leu Ser Phe Pro Ser Ile Ile His Arg Ala
         355                 360                 365

 ttc tta cgt cct tct ttt gac aag gcc aga gtc ttt caa aga aac atc     1208
 Phe Leu Arg Pro Ser Phe Asp Lys Ala Arg Val Phe Gln Arg Asn Ile
     370                 375                 380

 aat ttg aac tac cat cca tgc atg aag ata cct ttg caa gag cta agg     1256
 Asn Leu Asn Tyr His Pro Cys Met Lys Ile Pro Leu Gln Glu Leu Arg
 385                 390                 395                 400

 aac cca ggt gaa aga tta tag ca cctcagctcc agaacgcctt ccacatatgg     1309
 Asn Pro Gly Glu Arg Leu 
                 405

 aggctccagg actgccccag aaccaggccc atgtcttatg gaccaaggta tcaggcccaa   1369

 gtccccactg atcagtcacc aaggcagcct acccaaggac tccagcagta aacctgctca   1429

 taggcctcgc cagctgttcc agcctgaatc cctggacagg ctgatttgta aacggctttc   1489

 catgctgaaa cccatcaaag cagagcctgc attttcacaa gatccccagc tgatgtacag   1549

 gcccattagg actgagaagt actgctctag ggacacagat gatggaatca ggccttatgc   1609

 tcttgctaag cagaatgagt cacaacctta cctcctcttt gttctttgtg gtggctacag   1669

 agatgtgcca cccaccgcat ggcccttcaa tgaagtacta gtcccagctg ccctcctaaa   1729

 ggggcagctg gctttcagtg atgaacagga gtcattcatt gtgactcatc cacaatcatg   1789

 caaacaacca gctgaagatg agggaacaac ttgttggaag gaacccaagg ctctgcatga   1849

 ccatttgggg tacagctact tactgactgg gaatgtttac ctacagcttt tagcagtagt   1909

 aaggtttgag tttcgaatac agatccagca cctcacttct aatatctcta aactgccaaa   1969

 aatcaaagta gcaccaacta aagttgggaa agaacatgag gctttcttat cacactctta   2029

 cgtcagaata gaaggtatgg taaaacatgc agacacagaa atgactgtca taaaggaagt   2089

 ttattatact caagagtccc ctagaaaccg gaggtacagc atggcatgcc atgcaggggg   2149

 cacacaggga agcagcagga tcaggcagga ggcaggggga acaagaagaa atgtgggcaa   2209

 gagccttacg gtggtttcca tgggaaggaa tgagcaaagc agg                     2252




      <210> 166
      <211> 1844
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (30)..(1568)

      <400> 166
 cagtctcagg ccaagagctg caggctggc  atg gct ggg ggg atg tca gca gag      53
                                  Met Ala Gly Gly Met Ser Ala Glu
                                    1               5

 tgc cct gag cct ggg cca gga ggt ctg cag ggc cag tcc cca ggg cca      101
 Cys Pro Glu Pro Gly Pro Gly Gly Leu Gln Gly Gln Ser Pro Gly Pro
      10                  15                  20

 ggc agg cag tgt ccc cct ccc atc acg ccc acc tcc tgg agc ctg ccc      149
 Gly Arg Gln Cys Pro Pro Pro Ile Thr Pro Thr Ser Trp Ser Leu Pro
  25                  30                  35                  40

 ccg tgg agg gcc tac gtg gct gcc gcc gtc ctc tgc tac atc aac ctc      197
 Pro Trp Arg Ala Tyr Val Ala Ala Ala Val Leu Cys Tyr Ile Asn Leu
                  45                  50                  55

 ctg aat tac atg aac tgg ttc atc att gca gga gtg ctg ctg gat ata      245
 Leu Asn Tyr Met Asn Trp Phe Ile Ile Ala Gly Val Leu Leu Asp Ile
              60                  65                  70

 cag gag gtt ttc cag atc agt gac aac cat gct ggt ttg ctt cag act      293
 Gln Glu Val Phe Gln Ile Ser Asp Asn His Ala Gly Leu Leu Gln Thr
          75                  80                  85

 gtc ttc gtt agc tgc ctg ctg ctg tct gca cct gtg ttt ggc tac ctg      341
 Val Phe Val Ser Cys Leu Leu Leu Ser Ala Pro Val Phe Gly Tyr Leu
      90                  95                 100

 ggc gac cga cat agc cgc aag gct acc atg agc ttc ggt atc ttg ctg      389
 Gly Asp Arg His Ser Arg Lys Ala Thr Met Ser Phe Gly Ile Leu Leu
 105                 110                 115                 120

 tgg tca gga gct ggc ctc tct agc tcc ttc atc tcc ccc cgg tat tct      437
 Trp Ser Gly Ala Gly Leu Ser Ser Ser Phe Ile Ser Pro Arg Tyr Ser
                 125                 130                 135

 tgg ctc ttc ttc ctg tcc cgg ggc atc gtg ggc act ggc tcg gcc agc      485
 Trp Leu Phe Phe Leu Ser Arg Gly Ile Val Gly Thr Gly Ser Ala Ser
             140                 145                 150

 tac tcc acc atc gcg ccc acc gtc ctg ggc gac ctc ttc gtg agg gac      533
 Tyr Ser Thr Ile Ala Pro Thr Val Leu Gly Asp Leu Phe Val Arg Asp
         155                 160                 165

 cag cgc acc cgc gtg ctg gct gtc ttc tac atc ttt atc ccc gtt gga      581
 Gln Arg Thr Arg Val Leu Ala Val Phe Tyr Ile Phe Ile Pro Val Gly
     170                 175                 180

 agt ggt ctg ggc tac gtg ctg ggg tcg gct gtg acg atg ctg act ggg      629
 Ser Gly Leu Gly Tyr Val Leu Gly Ser Ala Val Thr Met Leu Thr Gly
 185                 190                 195                 200

 aac tgg cgc tgg gcc ctc cga gtc atg ccc tgc ctg gag gcc gtg gcc      677
 Asn Trp Arg Trp Ala Leu Arg Val Met Pro Cys Leu Glu Ala Val Ala
                 205                 210                 215

 ttg atc ctg ctt atc ctg ctg gtt cca gac cca ccc cgg gga gct gcc      725
 Leu Ile Leu Leu Ile Leu Leu Val Pro Asp Pro Pro Arg Gly Ala Ala
             220                 225                 230

 gag aca cag ggg gag ggg gcc gtg gga ggc ttc agg agc agc tgg tgt      773
 Glu Thr Gln Gly Glu Gly Ala Val Gly Gly Phe Arg Ser Ser Trp Cys
         235                 240                 245

 gag gac gtc aga tac ctg ggg aaa aac tgg agt ttt gtg tgg tcg acc      821
 Glu Asp Val Arg Tyr Leu Gly Lys Asn Trp Ser Phe Val Trp Ser Thr
     250                 255                 260

 ctc gga gtg acc gcc atg gcc ttt gtg act gga gcc ctg ggg ttc tgg      869
 Leu Gly Val Thr Ala Met Ala Phe Val Thr Gly Ala Leu Gly Phe Trp
 265                 270                 275                 280

 gcc ccc aag ttt ctg ctc gag gca cgc gtg gtt cac ggg ctg cag cct      917
 Ala Pro Lys Phe Leu Leu Glu Ala Arg Val Val His Gly Leu Gln Pro
                 285                 290                 295

 ccc tgc ttc cag gag ccg tgc agc aac ccc gac agc ctg att ttt ggg      965
 Pro Cys Phe Gln Glu Pro Cys Ser Asn Pro Asp Ser Leu Ile Phe Gly
             300                 305                 310

 gca ctg acc atc atg acc ggc gtc att ggg gtc atc ttg ggg gca gaa     1013
 Ala Leu Thr Ile Met Thr Gly Val Ile Gly Val Ile Leu Gly Ala Glu
         315                 320                 325

 gct gcg agg agg tac aag aaa gtc att cca gga gct gag ccc ctc atc     1061
 Ala Ala Arg Arg Tyr Lys Lys Val Ile Pro Gly Ala Glu Pro Leu Ile
     330                 335                 340

 tgc gcc tcc agc ctg ctt gcc aca gcc ccc tgc ctc tac ctg gct ctc     1109
 Cys Ala Ser Ser Leu Leu Ala Thr Ala Pro Cys Leu Tyr Leu Ala Leu
 345                 350                 355                 360

 gtc ctg gcc ccg acc acc ctg ctg gcc tcc tat gtg ttc ctg ggc ctt     1157
 Val Leu Ala Pro Thr Thr Leu Leu Ala Ser Tyr Val Phe Leu Gly Leu
                 365                 370                 375

 ggg gag ctg ctt ctg tcc tgc aac tgg gca gtg gtt gcc gac atc ctg     1205
 Gly Glu Leu Leu Leu Ser Cys Asn Trp Ala Val Val Ala Asp Ile Leu
             380                 385                 390

 ctg tct gtg gtg gtg ccc aga tgc cgg ggg acg gca gag gca ctt cag     1253
 Leu Ser Val Val Val Pro Arg Cys Arg Gly Thr Ala Glu Ala Leu Gln
         395                 400                 405

 atc acg gtg ggc cac atc ctg gga gac gct ggc agc ccc tat ctc aca     1301
 Ile Thr Val Gly His Ile Leu Gly Asp Ala Gly Ser Pro Tyr Leu Thr
     410                 415                 420

 gga ctt atc tct agt gtc ctg cgg gcc agg cgc cct gac tcc tat ctg     1349
 Gly Leu Ile Ser Ser Val Leu Arg Ala Arg Arg Pro Asp Ser Tyr Leu
 425                 430                 435                 440

 cag cgc ttc cgc agc ctg cag cag agc ttc ctg tgc tgc gcc ttt gtc     1397
 Gln Arg Phe Arg Ser Leu Gln Gln Ser Phe Leu Cys Cys Ala Phe Val
                 445                 450                 455

 atc gcc ctg ggg ggc ggc tgc ttc ctg ctg act gcg ctg tac ctg gag     1445
 Ile Ala Leu Gly Gly Gly Cys Phe Leu Leu Thr Ala Leu Tyr Leu Glu
             460                 465                 470

 aga gac gag acc cgg gcc tgg cag cct gtc aca ggg acc cca gac agc     1493
 Arg Asp Glu Thr Arg Ala Trp Gln Pro Val Thr Gly Thr Pro Asp Ser
         475                 480                 485

 aat gat gtg gac agc aac gac ctg gag aga caa ggc cta ctt tcg ggc     1541
 Asn Asp Val Asp Ser Asn Asp Leu Glu Arg Gln Gly Leu Leu Ser Gly
     490                 495                 500

 gct ggc gcc tct aca gag gag ccc tga ggtcc ctgcctacac tcgtcctgcc     1593
 Ala Gly Ala Ser Thr Glu Glu Pro 
 505                 510

 tgcaagcctc ccgttggtcc ccacagcagc agtgcctcgg ttcctctttg gctgtcctcg   1653

 gggactccgg ctgaggcaca tctgctactt ttgaattccc ggctggagag ctggcaggac   1713

 cctgtggctg ggctgggaat ggagctgtca gcactctgcg tgggaggcct gggcctgtgc   1773

 ctgcatcccg ctcaaggctg ccccagcctg gggtctccag cctggctgct gctgggccct   1833

 gaataaagag a                                                        1844




      <210> 167
      <211> 3450
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (1)..(3450)

      <400> 167
  atg acg tcc tta gcc cag cag ctg caa cga ctc gcc ctc cct caa agt      48
  Met Thr Ser Leu Ala Gln Gln Leu Gln Arg Leu Ala Leu Pro Gln Ser
    1               5                  10                  15

 gat gcc agc ctc tta tct aga gat gaa gtt gct tct ttg tta ttt gac       96
 Asp Ala Ser Leu Leu Ser Arg Asp Glu Val Ala Ser Leu Leu Phe Asp
              20                  25                  30

 cct aag gaa gcg gcc aca atc gac agg gac acc gcc ttc gcc att gga      144
 Pro Lys Glu Ala Ala Thr Ile Asp Arg Asp Thr Ala Phe Ala Ile Gly
          35                  40                  45

 tgt act ggc ctg gaa gag ttg ctt gga att gat cct tcc ttt gag cag      192
 Cys Thr Gly Leu Glu Glu Leu Leu Gly Ile Asp Pro Ser Phe Glu Gln
      50                  55                  60

 ttt gaa gca ccg ttg ttc agt cag cta gca aaa acc ttg gag cga agt      240
 Phe Glu Ala Pro Leu Phe Ser Gln Leu Ala Lys Thr Leu Glu Arg Ser
  65                  70                  75                  80

 gtt cag acc aaa gca caa tct gga gtg ccg tta gct aaa gga act ttg      288
 Val Gln Thr Lys Ala Gln Ser Gly Val Pro Leu Ala Lys Gly Thr Leu
                  85                  90                  95

 att acc cac tgc tac aaa gat ctt gga ttc atg gat ttc att tgc agt      336
 Ile Thr His Cys Tyr Lys Asp Leu Gly Phe Met Asp Phe Ile Cys Ser
             100                 105                 110

 ttg gtg aca aaa tct gtg aag gtt ttt gct gag tac ccg ggc agc tca      384
 Leu Val Thr Lys Ser Val Lys Val Phe Ala Glu Tyr Pro Gly Ser Ser
         115                 120                 125

 gct cag ttg agg gtg ctc ttg gct ttc tat gct tct acc ata gtg tcg      432
 Ala Gln Leu Arg Val Leu Leu Ala Phe Tyr Ala Ser Thr Ile Val Ser
     130                 135                 140

 gcg ctg gta gct gca gag gac gta tca gac aat atc atc gcc aaa cta      480
 Ala Leu Val Ala Ala Glu Asp Val Ser Asp Asn Ile Ile Ala Lys Leu
 145                 150                 155                 160

 ttt ccc tat atc caa aag atc atc aaa aca ttg acc aag att ccc tct      528
 Phe Pro Tyr Ile Gln Lys Ile Ile Lys Thr Leu Thr Lys Ile Pro Ser
                 165                 170                 175

 ttg atc aag gat ggg tta agt tgc ttg ata gtg ctc ctg cag aga cag      576
 Leu Ile Lys Asp Gly Leu Ser Cys Leu Ile Val Leu Leu Gln Arg Gln
             180                 185                 190

 aag cca gag agc ctt ggg aaa aag tac gag gta ctt aag ata gcc gct      624
 Lys Pro Glu Ser Leu Gly Lys Lys Tyr Glu Val Leu Lys Ile Ala Ala
         195                 200                 205

 gac ata tta att aaa gaa gag ata ctg agt gaa aat gat cag ttg tca      672
 Asp Ile Leu Ile Lys Glu Glu Ile Leu Ser Glu Asn Asp Gln Leu Ser
     210                 215                 220

 aat cag gtg gtt gta tgt ttg ctg cca ttt atg gtt atc aat aat gat      720
 Asn Gln Val Val Val Cys Leu Leu Pro Phe Met Val Ile Asn Asn Asp
 225                 230                 235                 240

 gat acg gaa tct gct gag atg aaa att gct ata tat tta tca aaa tca      768
 Asp Thr Glu Ser Ala Glu Met Lys Ile Ala Ile Tyr Leu Ser Lys Ser
                 245                 250                 255

 gga atc tgc tcc ctg cac cct cta tta aga ggc tgg gaa gaa ggt gat      816
 Gly Ile Cys Ser Leu His Pro Leu Leu Arg Gly Trp Glu Glu Gly Asp
             260                 265                 270

 ata tgg tgg aat cct gaa caa ctg aaa gaa gac agc agg gac tat ctg      864
 Ile Trp Trp Asn Pro Glu Gln Leu Lys Glu Asp Ser Arg Asp Tyr Leu
         275                 280                 285

 cac ttg ctc att ggg ctg ttt gag atg atg ctc aat ggt gcc gat gct      912
 His Leu Leu Ile Gly Leu Phe Glu Met Met Leu Asn Gly Ala Asp Ala
     290                 295                 300

 gtt cat ttc aga gtt ctg atg aaa ctt ttc ata aag atg gtg ctt tct      960
 Val His Phe Arg Val Leu Met Lys Leu Phe Ile Lys Met Val Leu Ser
 305                 310                 315                 320

 cag cta ttg cct atg gct gaa caa ctg cta gaa aag atc cag aag gag     1008
 Gln Leu Leu Pro Met Ala Glu Gln Leu Leu Glu Lys Ile Gln Lys Glu
                 325                 330                 335

 ccc aca gct gtg ctg aaa gat gag gcc atg gtt ctg cat ctc act ctg     1056
 Pro Thr Ala Val Leu Lys Asp Glu Ala Met Val Leu His Leu Thr Leu
             340                 345                 350

 gga aag tat aat gaa ttt tca gtt tcc ctt tta aat gag gat ccg aag     1104
 Gly Lys Tyr Asn Glu Phe Ser Val Ser Leu Leu Asn Glu Asp Pro Lys
         355                 360                 365

 agt cta gat ata ttt ata aaa gct gtg cac aca aca aag gaa ctt tac     1152
 Ser Leu Asp Ile Phe Ile Lys Ala Val His Thr Thr Lys Glu Leu Tyr
     370                 375                 380

 gcg gga atg cca acc att cag atc aca gcc ctt gaa aag ctg att aga     1200
 Ala Gly Met Pro Thr Ile Gln Ile Thr Ala Leu Glu Lys Leu Ile Arg
 385                 390                 395                 400

 ata tac ata tct gat ccg gca ctt gga aac aat cgt tgt ctg ctc aac     1248
 Ile Tyr Ile Ser Asp Pro Ala Leu Gly Asn Asn Arg Cys Leu Leu Asn
                 405                 410                 415

 atc tgc caa aaa cta tct cca gat ggt ggc aaa ata ccc aaa gat att     1296
 Ile Cys Gln Lys Leu Ser Pro Asp Gly Gly Lys Ile Pro Lys Asp Ile
             420                 425                 430

 tta gat gag gag aag ttc aac gtg gag ttg ata gtt cag tgc atc cgc     1344
 Leu Asp Glu Glu Lys Phe Asn Val Glu Leu Ile Val Gln Cys Ile Arg
         435                 440                 445

 ctt tcg gag atg ccg cag acc cat cac cat gcc ctt tta ctt ttg ggc     1392
 Leu Ser Glu Met Pro Gln Thr His His His Ala Leu Leu Leu Leu Gly
     450                 455                 460

 act gtt gct gga ata ttt ccg gat aaa gtt tta cac aat atc atg tct     1440
 Thr Val Ala Gly Ile Phe Pro Asp Lys Val Leu His Asn Ile Met Ser
 465                 470                 475                 480

 att ttt aca ttt atg gga gcc aat gtc atg cgc cta gat gat act tac     1488
 Ile Phe Thr Phe Met Gly Ala Asn Val Met Arg Leu Asp Asp Thr Tyr
                 485                 490                 495

 agt ttt caa gtt att aac aag aca gtg aaa atg gtt att ccc gca ctt     1536
 Ser Phe Gln Val Ile Asn Lys Thr Val Lys Met Val Ile Pro Ala Leu
             500                 505                 510

 att cag tct gat agt gga gat tct ata gaa gtt tca aga aac gtt gaa     1584
 Ile Gln Ser Asp Ser Gly Asp Ser Ile Glu Val Ser Arg Asn Val Glu
         515                 520                 525

 gag att gtg gta aaa atc att agt gta ttt gtg gat gcg ctg cca cac     1632
 Glu Ile Val Val Lys Ile Ile Ser Val Phe Val Asp Ala Leu Pro His
     530                 535                 540

 gtc ccg gag cac agg cgc ctg ccc atc ctt gtt caa ctt gtt gat aca     1680
 Val Pro Glu His Arg Arg Leu Pro Ile Leu Val Gln Leu Val Asp Thr
 545                 550                 555                 560

 ctg ggt gca gag aaa ttc ctc tgg att ctc ctc atc ttg ctt ttt gaa     1728
 Leu Gly Ala Glu Lys Phe Leu Trp Ile Leu Leu Ile Leu Leu Phe Glu
                 565                 570                 575

 cag tat gtc aca aaa aca gtg ctg gcg gct gcc tat ggc gaa aag gat     1776
 Gln Tyr Val Thr Lys Thr Val Leu Ala Ala Ala Tyr Gly Glu Lys Asp
             580                 585                 590

 gct att tta gaa gca gac act gaa ttt tgg ttt tca gtc tgt tgt gag     1824
 Ala Ile Leu Glu Ala Asp Thr Glu Phe Trp Phe Ser Val Cys Cys Glu
         595                 600                 605

 ttt agt gtc cag cat cag ata caa agc ttg atg aat atc ctc cag tac     1872
 Phe Ser Val Gln His Gln Ile Gln Ser Leu Met Asn Ile Leu Gln Tyr
     610                 615                 620

 tta cta aag ctg cca gag gaa aaa gaa gct aaa gag aaa cag aag aga     1920
 Leu Leu Lys Leu Pro Glu Glu Lys Glu Ala Lys Glu Lys Gln Lys Arg
 625                 630                 635                 640

 atg cag gtt atc ctt agt aca tct tca gaa gga ttt tta aag ttg ctg     1968
 Met Gln Val Ile Leu Ser Thr Ser Ser Glu Gly Phe Leu Lys Leu Leu
                 645                 650                 655

 gag acc gtt ctc ggc tat atc agt gca gtt gca cag tcc atg gaa agg     2016
 Glu Thr Val Leu Gly Tyr Ile Ser Ala Val Ala Gln Ser Met Glu Arg
             660                 665                 670

 aac gca gac aaa ctc acc gtg aag ttc tgg cgc gcg ctc ctt agt aaa     2064
 Asn Ala Asp Lys Leu Thr Val Lys Phe Trp Arg Ala Leu Leu Ser Lys
         675                 680                 685

 gct tac gac ctg tta gat aag gtt acc cgt ttc cta aaa ctg gtt cca     2112
 Ala Tyr Asp Leu Leu Asp Lys Val Thr Arg Phe Leu Lys Leu Val Pro
     690                 695                 700

 gac ctt ttg gcc att gtg cag cgt aag aaa aag gaa ggg gaa gaa gaa     2160
 Asp Leu Leu Ala Ile Val Gln Arg Lys Lys Lys Glu Gly Glu Glu Glu
 705                 710                 715                 720

 caa gca atc aac aga cag aca gca ttg tat acc tta aag ctt tta tgc     2208
 Gln Ala Ile Asn Arg Gln Thr Ala Leu Tyr Thr Leu Lys Leu Leu Cys
                 725                 730                 735

 aag aat ttt ggt gca gaa aat cca gat cct ttt gtc cca gtg ctg aac     2256
 Lys Asn Phe Gly Ala Glu Asn Pro Asp Pro Phe Val Pro Val Leu Asn
             740                 745                 750

 act gct gtg aaa ctg att gct cca gag aga aag gag gag aag aat gtc     2304
 Thr Ala Val Lys Leu Ile Ala Pro Glu Arg Lys Glu Glu Lys Asn Val
         755                 760                 765

 ctg gga agc gcg ctg ctg tgc ata gca gag gtg acc tcc acc ctg gag     2352
 Leu Gly Ser Ala Leu Leu Cys Ile Ala Glu Val Thr Ser Thr Leu Glu
     770                 775                 780

 gcg ctg gcc atc ccc cag ctt ccc agc ctg atg cca tcg ttg ctg aca     2400
 Ala Leu Ala Ile Pro Gln Leu Pro Ser Leu Met Pro Ser Leu Leu Thr
 785                 790                 795                 800

 aca atg aag aac acc agc gag ctg gtc tcc agc gag gtc tac ctg ctc     2448
 Thr Met Lys Asn Thr Ser Glu Leu Val Ser Ser Glu Val Tyr Leu Leu
                 805                 810                 815

 agt gcc ttg gct gct ctg cag aag gtt gtg gag act ctc ccg cac ttc     2496
 Ser Ala Leu Ala Ala Leu Gln Lys Val Val Glu Thr Leu Pro His Phe
             820                 825                 830

 atc agc ccc tat ctg gaa ggc att ctc tcc cag aat cac atg ggt ccg     2544
 Ile Ser Pro Tyr Leu Glu Gly Ile Leu Ser Gln Asn His Met Gly Pro
         835                 840                 845

 ttt atg agc atc ttg caa gag cat att ggg gtg atg aag aag gaa gag     2592
 Phe Met Ser Ile Leu Gln Glu His Ile Gly Val Met Lys Lys Glu Glu
     850                 855                 860

 ctc acc tcc cat cag tct cag cta acc gcc ttt ttc ctg gaa gcc ctg     2640
 Leu Thr Ser His Gln Ser Gln Leu Thr Ala Phe Phe Leu Glu Ala Leu
 865                 870                 875                 880

 gac ttc cga gcc cag cac tct gag aac gat ctg gag gaa gtt gga aaa     2688
 Asp Phe Arg Ala Gln His Ser Glu Asn Asp Leu Glu Glu Val Gly Lys
                 885                 890                 895

 acg gaa aat tgt atc att gac tgt cta gta gcc atg gtt gtc aaa ctt     2736
 Thr Glu Asn Cys Ile Ile Asp Cys Leu Val Ala Met Val Val Lys Leu
             900                 905                 910

 tcc gag gtc aca ttc agg ccc ctg ttc ttc aag ctg ttt gat tgg gct     2784
 Ser Glu Val Thr Phe Arg Pro Leu Phe Phe Lys Leu Phe Asp Trp Ala
         915                 920                 925

 aaa aca gaa gat gcc cca aag gac agg ttg ttg aca ttt tac aac ttg     2832
 Lys Thr Glu Asp Ala Pro Lys Asp Arg Leu Leu Thr Phe Tyr Asn Leu
     930                 935                 940

 gca gat tgc att gct gaa aag ctg aaa ggg ctt ttt act ctg ttt gcc     2880
 Ala Asp Cys Ile Ala Glu Lys Leu Lys Gly Leu Phe Thr Leu Phe Ala
 945                 950                 955                 960

 ggc cac tta gtg aag cct ttt gct gac acc ttg aac cag gtg aac atc     2928
 Gly His Leu Val Lys Pro Phe Ala Asp Thr Leu Asn Gln Val Asn Ile
                 965                 970                 975

 tcc aaa aca gat gaa gca ttt ttt gac tct gaa aat gac cct gaa aag     2976
 Ser Lys Thr Asp Glu Ala Phe Phe Asp Ser Glu Asn Asp Pro Glu Lys
             980                 985                 990

 tgc tgc ttg ctg ttg cag ttt att ttg aac tgt tta tac aaa atc ttc     3024
 Cys Cys Leu Leu Leu Gln Phe Ile Leu Asn Cys Leu Tyr Lys Ile Phe
         995                1000                1005

 ctt ttt gat acc cag cat ttt ata agt aaa gag aga gca gaa gcc ttg     3072
 Leu Phe Asp Thr Gln His Phe Ile Ser Lys Glu Arg Ala Glu Ala Leu
    1010                1015                1020

 atg atg cct ctg gtg gat cag ctg gaa aac agg ctt ggg gga gaa gag     3120
 Met Met Pro Leu Val Asp Gln Leu Glu Asn Arg Leu Gly Gly Glu Glu
1025                1030                1035                1040

 aaa ttc cag gaa cgg gtg aca aag cac ctg ata cca tgc atc gca cag     3168
 Lys Phe Gln Glu Arg Val Thr Lys His Leu Ile Pro Cys Ile Ala Gln
                1045                1050                1055

 ttt tcg gtg gcc atg gcg gat gac tct ctt tgg aaa cca ctg aac tac     3216
 Phe Ser Val Ala Met Ala Asp Asp Ser Leu Trp Lys Pro Leu Asn Tyr
            1060                1065                1070

 cag att ctg cta aag acg aga gac tcc tcg cct aag gtt cga ttt gct     3264
 Gln Ile Leu Leu Lys Thr Arg Asp Ser Ser Pro Lys Val Arg Phe Ala
        1075                1080                1085

 gct ttg att act gtg tta gca ctg gct gaa aaa cta aag gag aat tat     3312
 Ala Leu Ile Thr Val Leu Ala Leu Ala Glu Lys Leu Lys Glu Asn Tyr
    1090                1095                1100

 att gtc ttg cta cca gaa tcc att cct ttc tta gca gag ttg atg gaa     3360
 Ile Val Leu Leu Pro Glu Ser Ile Pro Phe Leu Ala Glu Leu Met Glu
1105                1110                1115                1120

 gat gaa tgt gaa gaa gta gaa cat cag tgc caa aag act att cag caa     3408
 Asp Glu Cys Glu Glu Val Glu His Gln Cys Gln Lys Thr Ile Gln Gln
                1125                1130                1135

 ctg gaa act gtc ctg gga gag cca ctc cag agc tat ttc taa             3450
 Leu Glu Thr Val Leu Gly Glu Pro Leu Gln Ser Tyr Phe 
            1140                1145





      <210> 168
      <211> 1656
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (43)..(1542)

      <400> 168
 gaggctggca ggcaggaggg ctggggcgag cactgggggg cc   atg gag cgg gca      54
                                                  Met Glu Arg Ala
                                                    1

 gaa gag ccc gtg gtc tat cag aag ctg ctg ccc tgg gag cca agc ttg      102
 Glu Glu Pro Val Val Tyr Gln Lys Leu Leu Pro Trp Glu Pro Ser Leu
   5                  10                  15                  20

 gag tcg gag gag gaa gtg gag gag gag gag aca tca gag gcg ctg gtt      150
 Glu Ser Glu Glu Glu Val Glu Glu Glu Glu Thr Ser Glu Ala Leu Val
                  25                  30                  35

 cta aac ccc cgg agg cac cag gac tct tcc agg aac aag gct ggc ggg      198
 Leu Asn Pro Arg Arg His Gln Asp Ser Ser Arg Asn Lys Ala Gly Gly
              40                  45                  50

 ctg ccc gga acc tgg gcc cgt gta gtg gca gcc ctg ctg ctg ctg gct      246
 Leu Pro Gly Thr Trp Ala Arg Val Val Ala Ala Leu Leu Leu Leu Ala
          55                  60                  65

 gtt ggc tgc tcc ctg gct gtg agg cag ctc cag aat cag ggc agg tcg      294
 Val Gly Cys Ser Leu Ala Val Arg Gln Leu Gln Asn Gln Gly Arg Ser
      70                  75                  80

 aca gga agc ttg ggc tct gtg gcc cct cca ccc ggc gga cac tcc cac      342
 Thr Gly Ser Leu Gly Ser Val Ala Pro Pro Pro Gly Gly His Ser His
  85                  90                  95                 100

 ggc cct ggc gta tac cac cac ggg gcc atc atc agc cct gca ccc aca      390
 Gly Pro Gly Val Tyr His His Gly Ala Ile Ile Ser Pro Ala Pro Thr
                 105                 110                 115

 tgc tcc cac cta ggc cga gag ctg ctt gtt gcc ggg ggc aac gtc gtg      438
 Cys Ser His Leu Gly Arg Glu Leu Leu Val Ala Gly Gly Asn Val Val
             120                 125                 130

 gat gct gga gtt gga gct gca ttg tgc ctg gca gtg gtg cat cct cat      486
 Asp Ala Gly Val Gly Ala Ala Leu Cys Leu Ala Val Val His Pro His
         135                 140                 145

 gcc acg ggg cta ggt gcc atg ttt tgg ggc ctc ttc cac gat agc tcc      534
 Ala Thr Gly Leu Gly Ala Met Phe Trp Gly Leu Phe His Asp Ser Ser
     150                 155                 160

 tca ggc aat tcc acg gcc ctg aca tca ggc cca gca cag acc ctg gcc      582
 Ser Gly Asn Ser Thr Ala Leu Thr Ser Gly Pro Ala Gln Thr Leu Ala
 165                 170                 175                 180

 ccc ggc ctg ggg ctg ccc gcg gct ctg ccc acc ctg cac ctg ctg cat      630
 Pro Gly Leu Gly Leu Pro Ala Ala Leu Pro Thr Leu His Leu Leu His
                 185                 190                 195

 gca cgc ttc ggc cgc ctg ccc tgg cca cgc ctg cta gtg ggc ccc acc      678
 Ala Arg Phe Gly Arg Leu Pro Trp Pro Arg Leu Leu Val Gly Pro Thr
             200                 205                 210

 acg ctg gct cag gag ggc ttc ctg gtg gac aca ccc ctg gca agg gct      726
 Thr Leu Ala Gln Glu Gly Phe Leu Val Asp Thr Pro Leu Ala Arg Ala
         215                 220                 225

 ctg gtg gct cgg ggc aca gaa ggc ctc tgt cca cta ctt tgc cat gct      774
 Leu Val Ala Arg Gly Thr Glu Gly Leu Cys Pro Leu Leu Cys His Ala
     230                 235                 240

 gat ggg aca ccc ctg ggc gct ggg gcc cga gcc acc aac cca caa ctg      822
 Asp Gly Thr Pro Leu Gly Ala Gly Ala Arg Ala Thr Asn Pro Gln Leu
 245                 250                 255                 260

 gca gct gtg ctt cgc agc gca gcc ctc gct ccc acc tca gac ctt gct      870
 Ala Ala Val Leu Arg Ser Ala Ala Leu Ala Pro Thr Ser Asp Leu Ala
                 265                 270                 275

 ggg gat gct cta ctg agt cta ctg gcg gga gac ctg ggg gtg gag gtg      918
 Gly Asp Ala Leu Leu Ser Leu Leu Ala Gly Asp Leu Gly Val Glu Val
             280                 285                 290

 ccc tcg gct gtg ccc agg ccc act ttg gaa cca gca gag cag cta cct      966
 Pro Ser Ala Val Pro Arg Pro Thr Leu Glu Pro Ala Glu Gln Leu Pro
         295                 300                 305

 gtg ccc cag ggc atc ctg ttc acc acc ccc agt ccc tca gct ggc cca     1014
 Val Pro Gln Gly Ile Leu Phe Thr Thr Pro Ser Pro Ser Ala Gly Pro
     310                 315                 320

 gaa ctg ctg gca ctg ttg gag gca gcc ctg cgc tcc ggg gcg ccc atc     1062
 Glu Leu Leu Ala Leu Leu Glu Ala Ala Leu Arg Ser Gly Ala Pro Ile
 325                 330                 335                 340

 cct gac ccc tgc cca ccg ttc ctg cag act gct gtg agc ccc gag agc     1110
 Pro Asp Pro Cys Pro Pro Phe Leu Gln Thr Ala Val Ser Pro Glu Ser
                 345                 350                 355

 agt gcc ctg gcc gcc gtg gac agc agc ggc tct gtg ctc ctt ctc acc     1158
 Ser Ala Leu Ala Ala Val Asp Ser Ser Gly Ser Val Leu Leu Leu Thr
             360                 365                 370

 tcc tcg ctc aac tgc tcc ttt ggc tct gca cac ctg tcc cca agc act     1206
 Ser Ser Leu Asn Cys Ser Phe Gly Ser Ala His Leu Ser Pro Ser Thr
         375                 380                 385

 ggg gtt ctg ctc agc aac ctg gtg gcc aag tct acc act agt gcc tgg     1254
 Gly Val Leu Leu Ser Asn Leu Val Ala Lys Ser Thr Thr Ser Ala Trp
     390                 395                 400

 gcc tgc ccc ctc atc ctc cgt ggc agc ctg gat gac aca gag gct gat     1302
 Ala Cys Pro Leu Ile Leu Arg Gly Ser Leu Asp Asp Thr Glu Ala Asp
 405                 410                 415                 420

 gtg ttg ggg ctt gtg gct tca ggg acc cct gat gtg gcc agg gcc atg     1350
 Val Leu Gly Leu Val Ala Ser Gly Thr Pro Asp Val Ala Arg Ala Met
                 425                 430                 435

 act cac acc cta ctc agg cat ctg gca gca agg ccc cct acc cag gcc     1398
 Thr His Thr Leu Leu Arg His Leu Ala Ala Arg Pro Pro Thr Gln Ala
             440                 445                 450

 cag cac cag cat cag ggt cag caa gaa cca aca gag cat ccc agc act     1446
 Gln His Gln His Gln Gly Gln Gln Glu Pro Thr Glu His Pro Ser Thr
         455                 460                 465

 tgt ggc caa ggg acc ctg ctc cag gtg gca gcc cac aca gag cac gcc     1494
 Cys Gly Gln Gly Thr Leu Leu Gln Val Ala Ala His Thr Glu His Ala
     470                 475                 480

 cat gtc tcc agt gtc ccc cat gcc tgc tgc ccc ttc cag ggg ttc taa     1542
 His Val Ser Ser Val Pro His Ala Cys Cys Pro Phe Gln Gly Phe 
 485                 490                 495

 caggatgggg gtgggtctgg cagaaggcag agttatctga agcatggggg caggagcaga   1602

 gcagacacag cagcaatgga gtgtgcaccc gcagggtgtg gtgcctcact cctg         1656




      <210> 169
      <211> 4659
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (1)..(4659)

      <400> 169
  atg ggg agc ttg cag caa gcc ctt gtg tgc ttt gaa aag agg ctc gtg      48
  Met Gly Ser Leu Gln Gln Ala Leu Val Cys Phe Glu Lys Arg Leu Val
    1               5                  10                  15

 gtt gct cat gaa ctt gga gag gcc ttc aat aaa gcc cag gcc tat gga       96
 Val Ala His Glu Leu Gly Glu Ala Phe Asn Lys Ala Gln Ala Tyr Gly
              20                  25                  30

 gag ctg gga agt ctg cac agc caa tta ggg aat tac gaa caa gcc att      144
 Glu Leu Gly Ser Leu His Ser Gln Leu Gly Asn Tyr Glu Gln Ala Ile
          35                  40                  45

 tcc tgc ctt gaa cgc cag ctg aac att gct aga gat atg aaa gac cga      192
 Ser Cys Leu Glu Arg Gln Leu Asn Ile Ala Arg Asp Met Lys Asp Arg
      50                  55                  60

 gcc ctg gag agt gac gca gcc tgt ggc ctg ggg ggc gtt tac cag cag      240
 Ala Leu Glu Ser Asp Ala Ala Cys Gly Leu Gly Gly Val Tyr Gln Gln
  65                  70                  75                  80

 atg ggg gag tat gac aca gcc ctg cag tac cac cag ctt gat cta cag      288
 Met Gly Glu Tyr Asp Thr Ala Leu Gln Tyr His Gln Leu Asp Leu Gln
                  85                  90                  95

 ata gca gag gaa acc aac aac ccc acg tgc cag ggc cga gcc tat ggg      336
 Ile Ala Glu Glu Thr Asn Asn Pro Thr Cys Gln Gly Arg Ala Tyr Gly
             100                 105                 110

 aac ctg ggc ctg act tat gaa tcc ctg ggc acc ttc gag agg gct gtg      384
 Asn Leu Gly Leu Thr Tyr Glu Ser Leu Gly Thr Phe Glu Arg Ala Val
         115                 120                 125

 gtc tat caa gaa cag cac ttg agc att gct gca cag atg aat gac ttg      432
 Val Tyr Gln Glu Gln His Leu Ser Ile Ala Ala Gln Met Asn Asp Leu
     130                 135                 140

 gcg gcc aag acg gtg tca tat agt agc ctt gga agg acc cat cat gcc      480
 Ala Ala Lys Thr Val Ser Tyr Ser Ser Leu Gly Arg Thr His His Ala
 145                 150                 155                 160

 ttg cag aac tat tcc caa gca gtc atg tac tta cag gaa ggt tta agg      528
 Leu Gln Asn Tyr Ser Gln Ala Val Met Tyr Leu Gln Glu Gly Leu Arg
                 165                 170                 175

 tta gct gag caa ctg ggc cga aga gaa gat gag gca aaa att cgc cat      576
 Leu Ala Glu Gln Leu Gly Arg Arg Glu Asp Glu Ala Lys Ile Arg His
             180                 185                 190

 ggc ctt ggc ctc tcc ctt tgg gct agt gga aac ttg gag gag gcc caa      624
 Gly Leu Gly Leu Ser Leu Trp Ala Ser Gly Asn Leu Glu Glu Ala Gln
         195                 200                 205

 cac cag ctt tat agg gca tca gcc ttg ttt gaa aca atc cga cat gag      672
 His Gln Leu Tyr Arg Ala Ser Ala Leu Phe Glu Thr Ile Arg His Glu
     210                 215                 220

 gca cag ctg agc acg gac tac aaa ctc tcc ctc ttt gac ctg cag aca      720
 Ala Gln Leu Ser Thr Asp Tyr Lys Leu Ser Leu Phe Asp Leu Gln Thr
 225                 230                 235                 240

 tca tcc tac cag gcc ttg cag cgg gtg ctc gtc agc cta ggc cat cat      768
 Ser Ser Tyr Gln Ala Leu Gln Arg Val Leu Val Ser Leu Gly His His
                 245                 250                 255

 gat gaa gcc ctg gct gtg gca gaa agg gga cgg aca agg gca ttt gct      816
 Asp Glu Ala Leu Ala Val Ala Glu Arg Gly Arg Thr Arg Ala Phe Ala
             260                 265                 270

 gat ctt ctg gtg gaa cga caa aca gga caa caa gac tcc gac ccc tac      864
 Asp Leu Leu Val Glu Arg Gln Thr Gly Gln Gln Asp Ser Asp Pro Tyr
         275                 280                 285

 tcc cca gtc act att gat cag atc tta gag atg gta aat ggc cag agg      912
 Ser Pro Val Thr Ile Asp Gln Ile Leu Glu Met Val Asn Gly Gln Arg
     290                 295                 300

 gga cta gtg ctt tac tat tcc ctg gct gca ggc tat ctg tat agc tgg      960
 Gly Leu Val Leu Tyr Tyr Ser Leu Ala Ala Gly Tyr Leu Tyr Ser Trp
 305                 310                 315                 320

 ctg ctg gct cct ggg gca gga att gtg aag ttt cat gaa cac tac ctg     1008
 Leu Leu Ala Pro Gly Ala Gly Ile Val Lys Phe His Glu His Tyr Leu
                 325                 330                 335

 ggt gag aac aca gtg gaa aac tca agt gac ttc cag gcc agc agc agt     1056
 Gly Glu Asn Thr Val Glu Asn Ser Ser Asp Phe Gln Ala Ser Ser Ser
             340                 345                 350

 gta acc ctt cca aca gca acc ggc tca gcc ctg gag cag cac att gcc     1104
 Val Thr Leu Pro Thr Ala Thr Gly Ser Ala Leu Glu Gln His Ile Ala
         355                 360                 365

 agt gtc cgg gag gcc ctg ggg gtg gag tct cac tac tca agg gcc tgt     1152
 Ser Val Arg Glu Ala Leu Gly Val Glu Ser His Tyr Ser Arg Ala Cys
     370                 375                 380

 gcc agc agt gag aca gag agt gaa gcg gga gac atc atg gac cag caa     1200
 Ala Ser Ser Glu Thr Glu Ser Glu Ala Gly Asp Ile Met Asp Gln Gln
 385                 390                 395                 400

 ttt gaa gag atg aac aac aaa ctc aac tcg gtc act gac ccc act ggc     1248
 Phe Glu Glu Met Asn Asn Lys Leu Asn Ser Val Thr Asp Pro Thr Gly
                 405                 410                 415

 ttt ctg cgg atg gtt cgc cgc aat aac ctg ttt aac agg agc tgc cag     1296
 Phe Leu Arg Met Val Arg Arg Asn Asn Leu Phe Asn Arg Ser Cys Gln
             420                 425                 430

 agc atg acg agc ctg ttc agt aac act gtg tca ccg acc cag gac ggg     1344
 Ser Met Thr Ser Leu Phe Ser Asn Thr Val Ser Pro Thr Gln Asp Gly
         435                 440                 445

 acc tcc tct ctt ccc agg agg cag agc tcg ttt gcc aag ccc ccg ctc     1392
 Thr Ser Ser Leu Pro Arg Arg Gln Ser Ser Phe Ala Lys Pro Pro Leu
     450                 455                 460

 cgt gcc ctg tat gac ctg ctc atc gcg ccc atg gaa ggg ggc ctg atg     1440
 Arg Ala Leu Tyr Asp Leu Leu Ile Ala Pro Met Glu Gly Gly Leu Met
 465                 470                 475                 480

 cac tcc agc ggc ccc gtg ggc cgg cac cgg cag ctc atc ctg gtt ctg     1488
 His Ser Ser Gly Pro Val Gly Arg His Arg Gln Leu Ile Leu Val Leu
                 485                 490                 495

 gag ggg gag ctc tac ctc att cct ttc gcc ctc ctg aag gga agc tcc     1536
 Glu Gly Glu Leu Tyr Leu Ile Pro Phe Ala Leu Leu Lys Gly Ser Ser
             500                 505                 510

 tcc aat gag tac ctc tac gag cgc ttc ggc ctc ctt gct gtc cct tcc     1584
 Ser Asn Glu Tyr Leu Tyr Glu Arg Phe Gly Leu Leu Ala Val Pro Ser
         515                 520                 525

 atc cgc tcc ctc agc gtg cag tcc aag tct cac tta cgg aag aac ccg     1632
 Ile Arg Ser Leu Ser Val Gln Ser Lys Ser His Leu Arg Lys Asn Pro
     530                 535                 540

 ccc aca tac tcc agc tcc aca tcc atg gcg gct gtc atc ggc aac ccc     1680
 Pro Thr Tyr Ser Ser Ser Thr Ser Met Ala Ala Val Ile Gly Asn Pro
 545                 550                 555                 560

 aag cta cca tcg gcc gtg atg gac agg tgg ctg tgg ggg ccc atg cca     1728
 Lys Leu Pro Ser Ala Val Met Asp Arg Trp Leu Trp Gly Pro Met Pro
                 565                 570                 575

 tcg gcc gag gaa gag gcc tac atg gtg tcc gag ctg ctg ggc tgc cag     1776
 Ser Ala Glu Glu Glu Ala Tyr Met Val Ser Glu Leu Leu Gly Cys Gln
             580                 585                 590

 ccc cta gtg ggc agt gtg gcc acc aag gag agg gtc atg agt gcc ctg     1824
 Pro Leu Val Gly Ser Val Ala Thr Lys Glu Arg Val Met Ser Ala Leu
         595                 600                 605

 acc cag gct gaa tgc gtc cac ttt gcc acc cac atc tcc tgg aag ctg     1872
 Thr Gln Ala Glu Cys Val His Phe Ala Thr His Ile Ser Trp Lys Leu
     610                 615                 620

 tcg gcc ttg gtc ctc acg ccc agc atg gac ggc aac cct gcc agc agc     1920
 Ser Ala Leu Val Leu Thr Pro Ser Met Asp Gly Asn Pro Ala Ser Ser
 625                 630                 635                 640

 aag agc tcc ttc ggc cac ccc tac acg atc cct gag tcc ttg cgg gtg     1968
 Lys Ser Ser Phe Gly His Pro Tyr Thr Ile Pro Glu Ser Leu Arg Val
                 645                 650                 655

 cag gac gat gcc agt gat ggg gag agc atc tcg gac tgc ccg ccc ctg     2016
 Gln Asp Asp Ala Ser Asp Gly Glu Ser Ile Ser Asp Cys Pro Pro Leu
             660                 665                 670

 cag gag ctg ctg ctt act gcc gcc gac gtc ctg gac ctg cag ctg cct     2064
 Gln Glu Leu Leu Leu Thr Ala Ala Asp Val Leu Asp Leu Gln Leu Pro
         675                 680                 685

 gtg aag ctg gtg gtg ctt ggc tcc tcc cag gag tcc aac agc aaa gtc     2112
 Val Lys Leu Val Val Leu Gly Ser Ser Gln Glu Ser Asn Ser Lys Val
     690                 695                 700

 gca gcc gac ggg gtc atc gcg ctg aca agg gcc ttc ctg gct gcc ggc     2160
 Ala Ala Asp Gly Val Ile Ala Leu Thr Arg Ala Phe Leu Ala Ala Gly
 705                 710                 715                 720

 gct cag tgt gtc ctc gtg tct ctg tgg cct gtg cca gtg gct gct ttt     2208
 Ala Gln Cys Val Leu Val Ser Leu Trp Pro Val Pro Val Ala Ala Phe
                 725                 730                 735

 aag atg ttc atc cat gcc ttc tac tca tcc ctg ctg aac ggc ctg aaa     2256
 Lys Met Phe Ile His Ala Phe Tyr Ser Ser Leu Leu Asn Gly Leu Lys
             740                 745                 750

 gcc agc gcc gcc ctg ggg gag gcc atg aag gtg gtg cag agc agc aag     2304
 Ala Ser Ala Ala Leu Gly Glu Ala Met Lys Val Val Gln Ser Ser Lys
         755                 760                 765

 gcc ttc tcg cac ccc tcc aac tgg gca ggg ttc atg ctc atc ggg agt     2352
 Ala Phe Ser His Pro Ser Asn Trp Ala Gly Phe Met Leu Ile Gly Ser
     770                 775                 780

 gac gtt aag ctg aac agc ccc tca tca ctc atc ggc cag gcc ctc aca     2400
 Asp Val Lys Leu Asn Ser Pro Ser Ser Leu Ile Gly Gln Ala Leu Thr
 785                 790                 795                 800

 gag atc ctg cag cac ccg gag cgt gcg cgg gac gcc ctg cga gtg ctg     2448
 Glu Ile Leu Gln His Pro Glu Arg Ala Arg Asp Ala Leu Arg Val Leu
                 805                 810                 815

 ctg cac ctg gtg gag aaa tcc ctg cag cgc atc cag aat ggg cag cgc     2496
 Leu His Leu Val Glu Lys Ser Leu Gln Arg Ile Gln Asn Gly Gln Arg
             820                 825                 830

 aat gcc atg tac aca tcc cag cag agt gtg gag aac aaa gtg ggc ggc     2544
 Asn Ala Met Tyr Thr Ser Gln Gln Ser Val Glu Asn Lys Val Gly Gly
         835                 840                 845

 atc cct ggc tgg cag gcc ctc ctc acc gct gtg ggc ttc cgg ctg gac     2592
 Ile Pro Gly Trp Gln Ala Leu Leu Thr Ala Val Gly Phe Arg Leu Asp
     850                 855                 860

 ccc cca acc agt ggc ctg cca gcg gct gtc ttc ttc cca acc tcc gac     2640
 Pro Pro Thr Ser Gly Leu Pro Ala Ala Val Phe Phe Pro Thr Ser Asp
 865                 870                 875                 880

 ccg ggc gac cgg ctc cag cag tgc agc agc aca ctc cag tcc ctg ctg     2688
 Pro Gly Asp Arg Leu Gln Gln Cys Ser Ser Thr Leu Gln Ser Leu Leu
                 885                 890                 895

 ggt ctg ccc aat cct gcc ctc caa gcc ctt tgc aaa ctc atc act gcc     2736
 Gly Leu Pro Asn Pro Ala Leu Gln Ala Leu Cys Lys Leu Ile Thr Ala
             900                 905                 910

 tcc gag acg ggc gag cag ctc atc agc cgg gct gtt aaa aat atg gtt     2784
 Ser Glu Thr Gly Glu Gln Leu Ile Ser Arg Ala Val Lys Asn Met Val
         915                 920                 925

 gga atg ctc cac cag gtg ctg gtt cag ctc cag gct ggc gag aag gag     2832
 Gly Met Leu His Gln Val Leu Val Gln Leu Gln Ala Gly Glu Lys Glu
     930                 935                 940

 cag gac ttg gca tca gct ccc att cag gtc tcc atc agc gtc cag ctg     2880
 Gln Asp Leu Ala Ser Ala Pro Ile Gln Val Ser Ile Ser Val Gln Leu
 945                 950                 955                 960

 tgg cgg ctc ccg gga tgc cac gag ttc ctg gca gct cta ggt ttt gat     2928
 Trp Arg Leu Pro Gly Cys His Glu Phe Leu Ala Ala Leu Gly Phe Asp
                 965                 970                 975

 ctc tgt gaa gtt ggt cag gag gaa gta atc ctg aaa acc ggg aag caa     2976
 Leu Cys Glu Val Gly Gln Glu Glu Val Ile Leu Lys Thr Gly Lys Gln
             980                 985                 990

 gct aat cga cgg act gtg cac ttc gcg ctc cag tcc ctg ctg tct ctg     3024
 Ala Asn Arg Arg Thr Val His Phe Ala Leu Gln Ser Leu Leu Ser Leu
         995                1000                1005

 ttt gat tct act gag cta ccc aag cgc ctc agc ctt gac agc tcc tcc     3072
 Phe Asp Ser Thr Glu Leu Pro Lys Arg Leu Ser Leu Asp Ser Ser Ser
    1010                1015                1020

 tcc ctc gag tct ctt gct tct gct cag tct gtt tcc aac gcc ctg ccc     3120
 Ser Leu Glu Ser Leu Ala Ser Ala Gln Ser Val Ser Asn Ala Leu Pro
1025                1030                1035                1040

 ttg ggt tac cag caa ccc ccc ttc tct ccc acc ggt gcg gac agc atc     3168
 Leu Gly Tyr Gln Gln Pro Pro Phe Ser Pro Thr Gly Ala Asp Ser Ile
                1045                1050                1055

 gcc tca gat gcc atc tct gtg tac agt ctg agc tcc att gcc tcc tca     3216
 Ala Ser Asp Ala Ile Ser Val Tyr Ser Leu Ser Ser Ile Ala Ser Ser
            1060                1065                1070

 atg agc ttt gtc tcc aaa ccc gag ggt gga tca gag ggt gga ggc ccc     3264
 Met Ser Phe Val Ser Lys Pro Glu Gly Gly Ser Glu Gly Gly Gly Pro
        1075                1080                1085

 gga gga cgg cag gac cat gac cgg tcc aag aac gct tac ctg cag aga     3312
 Gly Gly Arg Gln Asp His Asp Arg Ser Lys Asn Ala Tyr Leu Gln Arg
    1090                1095                1100

 tcc acc ctg cct agg agc cag ctg cct ccc cag acc cgc cct gca ggc     3360
 Ser Thr Leu Pro Arg Ser Gln Leu Pro Pro Gln Thr Arg Pro Ala Gly
1105                1110                1115                1120

 aac aaa gat gaa gaa gaa tat gaa ggg ttt tct atc atc agt aac gag     3408
 Asn Lys Asp Glu Glu Glu Tyr Glu Gly Phe Ser Ile Ile Ser Asn Glu
                1125                1130                1135

 ccc ttg gcg acc tac caa gaa aac cga aac aca tgc ttc tca cca gac     3456
 Pro Leu Ala Thr Tyr Gln Glu Asn Arg Asn Thr Cys Phe Ser Pro Asp
            1140                1145                1150

 cac aaa caa ccc caa cct ggg aca gcc gga ggc atg aga gtc tcg gtg     3504
 His Lys Gln Pro Gln Pro Gly Thr Ala Gly Gly Met Arg Val Ser Val
        1155                1160                1165

 agc tcc aaa ggg agc atc agc act cca aat tct cca gtg aaa atg act     3552
 Ser Ser Lys Gly Ser Ile Ser Thr Pro Asn Ser Pro Val Lys Met Thr
    1170                1175                1180

 ctg att ccc agc ccc aac tca ccc ttc caa aag gtg gga aaa cta gca     3600
 Leu Ile Pro Ser Pro Asn Ser Pro Phe Gln Lys Val Gly Lys Leu Ala
1185                1190                1195                1200

 agc tca gat aca gga gaa tca gac cag tct agc aca gaa acg gac agt     3648
 Ser Ser Asp Thr Gly Glu Ser Asp Gln Ser Ser Thr Glu Thr Asp Ser
                1205                1210                1215

 acc gtg aaa tcc caa gaa gaa agc aac cca aaa ctg gat cca caa gag     3696
 Thr Val Lys Ser Gln Glu Glu Ser Asn Pro Lys Leu Asp Pro Gln Glu
            1220                1225                1230

 tta gcc cag aaa att ctg gag gag aca cag agt cat ctc att gcg gtg     3744
 Leu Ala Gln Lys Ile Leu Glu Glu Thr Gln Ser His Leu Ile Ala Val
        1235                1240                1245

 gag cgt ctt cag agg agc ggc ggc cag gtg agc aag agt aat aac cct     3792
 Glu Arg Leu Gln Arg Ser Gly Gly Gln Val Ser Lys Ser Asn Asn Pro
    1250                1255                1260

 gaa gac ggc gtt cag gcg ccc agc agc act gct gtc ttc aga gcg tca     3840
 Glu Asp Gly Val Gln Ala Pro Ser Ser Thr Ala Val Phe Arg Ala Ser
1265                1270                1275                1280

 gaa acc agt gcg ttc agc agg cct gtt ctc tcc cat cag aag agt cag     3888
 Glu Thr Ser Ala Phe Ser Arg Pro Val Leu Ser His Gln Lys Ser Gln
                1285                1290                1295

 cca tca cca gtc act gtt aaa cca aag ccc cca gcc agg agc tcc tcc     3936
 Pro Ser Pro Val Thr Val Lys Pro Lys Pro Pro Ala Arg Ser Ser Ser
            1300                1305                1310

 ctg ccc aag gtg agt tcc gga tat agc agc ccc acc acc tca gag atg     3984
 Leu Pro Lys Val Ser Ser Gly Tyr Ser Ser Pro Thr Thr Ser Glu Met
        1315                1320                1325

 tcc atc aaa gac agc ccg agc cag cac agt ggc cgg cca tcg ccc ggc     4032
 Ser Ile Lys Asp Ser Pro Ser Gln His Ser Gly Arg Pro Ser Pro Gly
    1330                1335                1340

 tgc gac tca cag act tcc cag ctg gac cag cct ctc ttt aaa ctg aag     4080
 Cys Asp Ser Gln Thr Ser Gln Leu Asp Gln Pro Leu Phe Lys Leu Lys
1345                1350                1355                1360

 tac ccc agc tct cct tac agc gct cac att tcc aaa tca cca agg aac     4128
 Tyr Pro Ser Ser Pro Tyr Ser Ala His Ile Ser Lys Ser Pro Arg Asn
                1365                1370                1375

 atg tcc cca agc tcc ggc cac cag tct cct gct ggc agt gca ccc tcc     4176
 Met Ser Pro Ser Ser Gly His Gln Ser Pro Ala Gly Ser Ala Pro Ser
            1380                1385                1390

 cca gct ctc tcc tac tcc tca gct gga tct gct cgc tca agt cca gca     4224
 Pro Ala Leu Ser Tyr Ser Ser Ala Gly Ser Ala Arg Ser Ser Pro Ala
        1395                1400                1405

 gac gct ccc gac ata gac aaa ctg aaa atg gca gcc att gat gaa aag     4272
 Asp Ala Pro Asp Ile Asp Lys Leu Lys Met Ala Ala Ile Asp Glu Lys
    1410                1415                1420

 gtg cag gct gtc cat aac ctg aag atg ttc tgg cag agc aca ccc cag     4320
 Val Gln Ala Val His Asn Leu Lys Met Phe Trp Gln Ser Thr Pro Gln
1425                1430                1435                1440

 cat tcc aca ggg cca atg aag atc ttc cgg ggg gct cct ggc acg atg     4368
 His Ser Thr Gly Pro Met Lys Ile Phe Arg Gly Ala Pro Gly Thr Met
                1445                1450                1455

 act tcc aaa agg gat gtc ctc agt ctg ttg aat ttg tca cca cgg cac     4416
 Thr Ser Lys Arg Asp Val Leu Ser Leu Leu Asn Leu Ser Pro Arg His
            1460                1465                1470

 aat aag aag gag gag gga gtg gat aag ctt gaa ctg aag gag ctg tcc     4464
 Asn Lys Lys Glu Glu Gly Val Asp Lys Leu Glu Leu Lys Glu Leu Ser
        1475                1480                1485

 ctg cag cag cat gac gga gct cca ccg aaa gcc cct ccc aac gga cac     4512
 Leu Gln Gln His Asp Gly Ala Pro Pro Lys Ala Pro Pro Asn Gly His
    1490                1495                1500

 tgg cgc acc gag acc acc tcg ctg ggc tca ctg ccg ctg ccc gcc ggc     4560
 Trp Arg Thr Glu Thr Thr Ser Leu Gly Ser Leu Pro Leu Pro Ala Gly
1505                1510                1515                1520

 cct ccc gcc aca gcc ccc gcg cgc cct ttg agg ctt cct tct gga aat     4608
 Pro Pro Ala Thr Ala Pro Ala Arg Pro Leu Arg Leu Pro Ser Gly Asn
                1525                1530                1535

 ggc tac aag ttc ctg tct cca gga aga ttt ttc cct tct tcc aaa tgc     4656
 Gly Tyr Lys Phe Leu Ser Pro Gly Arg Phe Phe Pro Ser Ser Lys Cys
            1540                1545                1550

 taa                                                                 4659
 






      <210> 170
      <211> 1491
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (34)..(1491)

      <400> 170
 gcccgctgcc gggcgcgggc ctcagacaat aca atg gtg ggt gaa gag aag atg      54
                                      Met Val Gly Glu Glu Lys Met
                                        1               5

 tct cta aga aac cgg ctg tca aag tcc agg gaa aat cct gag gaa gat      102
 Ser Leu Arg Asn Arg Leu Ser Lys Ser Arg Glu Asn Pro Glu Glu Asp
          10                  15                  20

 gaa gac cag aga atc cct gca aag gag tcc cta gag aca cct agt aat      150
 Glu Asp Gln Arg Ile Pro Ala Lys Glu Ser Leu Glu Thr Pro Ser Asn
      25                  30                  35

 ggt cga att gac ata aaa cag ttg ata gca aag aag ata aag ttg aca      198
 Gly Arg Ile Asp Ile Lys Gln Leu Ile Ala Lys Lys Ile Lys Leu Thr
  40                  45                  50                  55

 gca gag gca gag gca ata aat agc agc tct cca ata aat gtt gaa tct      246
 Ala Glu Ala Glu Ala Ile Asn Ser Ser Ser Pro Ile Asn Val Glu Ser
                  60                  65                  70

 gaa tct aga agt aga ttc cct gtc aag gaa gta gaa ata aca act cga      294
 Glu Ser Arg Ser Arg Phe Pro Val Lys Glu Val Glu Ile Thr Thr Arg
              75                  80                  85

 aaa aaa atc atg aaa tca ttt caa gaa ttg aag cca ttt ttt atg aag      342
 Lys Lys Ile Met Lys Ser Phe Gln Glu Leu Lys Pro Phe Phe Met Lys
          90                  95                 100

 gaa gtt ggc agt cac ttt gat gat ttt gtg acc aat ctc att gaa aag      390
 Glu Val Gly Ser His Phe Asp Asp Phe Val Thr Asn Leu Ile Glu Lys
     105                 110                 115

 tca gca tca tta gat aat ggt ggg tgc gct ctc aca acc ttt tct gtt      438
 Ser Ala Ser Leu Asp Asn Gly Gly Cys Ala Leu Thr Thr Phe Ser Val
 120                 125                 130                 135

 ctt gaa gga gag aaa aac aac cat aga gcg aag gat ttg aga gca cct      486
 Leu Glu Gly Glu Lys Asn Asn His Arg Ala Lys Asp Leu Arg Ala Pro
                 140                 145                 150

 cca gaa caa gga aag att ttt att gca agg cgc tct ctc tta gac aca      534
 Pro Glu Gln Gly Lys Ile Phe Ile Ala Arg Arg Ser Leu Leu Asp Thr
             155                 160                 165

 ctt gta gta gat tac att gat gaa gga agg ctg gtg ctt gag ttc agc      582
 Leu Val Val Asp Tyr Ile Asp Glu Gly Arg Leu Val Leu Glu Phe Ser
         170                 175                 180

 ctc ctg tct tat gct ttt ggc aaa ttt cct acc gtt gtt tgg acc tgg      630
 Leu Leu Ser Tyr Ala Phe Gly Lys Phe Pro Thr Val Val Trp Thr Trp
     185                 190                 195

 tgg atc atg ttc ctg tct aca ttt tca gtt ccc tat ttt ctg ttt caa      678
 Trp Ile Met Phe Leu Ser Thr Phe Ser Val Pro Tyr Phe Leu Phe Gln
 200                 205                 210                 215

 cat tgg gcc act ggc tat agc aag agt tct cat ccg ctg atc cgt tct      726
 His Trp Ala Thr Gly Tyr Ser Lys Ser Ser His Pro Leu Ile Arg Ser
                 220                 225                 230

 ctc ttc cat ggc ttt ctt ttc atg atc ttc cag att gga gtt cta ggt      774
 Leu Phe His Gly Phe Leu Phe Met Ile Phe Gln Ile Gly Val Leu Gly
             235                 240                 245

 ttt gga cca aca tat gtt gtg tta gca tat aca ctg cca cca gct tcc      822
 Phe Gly Pro Thr Tyr Val Val Leu Ala Tyr Thr Leu Pro Pro Ala Ser
         250                 255                 260

 cgg ttc atc att ata ttc gag cag att cgt ttt gta atg aag gcc cac      870
 Arg Phe Ile Ile Ile Phe Glu Gln Ile Arg Phe Val Met Lys Ala His
     265                 270                 275

 tca ttt gtc aga gag aac gtg cct cgg gta cta aat tca gct aag gag      918
 Ser Phe Val Arg Glu Asn Val Pro Arg Val Leu Asn Ser Ala Lys Glu
 280                 285                 290                 295

 aaa tca agc act gtt cca ata cct aca gtc aac cag tat ttg tac ttc      966
 Lys Ser Ser Thr Val Pro Ile Pro Thr Val Asn Gln Tyr Leu Tyr Phe
                 300                 305                 310

 tta ttt gct cct acc ctt atc tac cgt gac agc tat ccc agg aat ccc     1014
 Leu Phe Ala Pro Thr Leu Ile Tyr Arg Asp Ser Tyr Pro Arg Asn Pro
             315                 320                 325

 act gta aga tgg ggt tat gtc gct atg aag ttt gca cag gat tgg tgg     1062
 Thr Val Arg Trp Gly Tyr Val Ala Met Lys Phe Ala Gln Asp Trp Trp
         330                 335                 340

 aac tcc acg tca tac tcc aac tat tat aga acc tgg aat gtg gtg gtc     1110
 Asn Ser Thr Ser Tyr Ser Asn Tyr Tyr Arg Thr Trp Asn Val Val Val
     345                 350                 355

 cat gac tgg cta tat tac tat gct tac aag gac ttt ctc tgg ttt ttc     1158
 His Asp Trp Leu Tyr Tyr Tyr Ala Tyr Lys Asp Phe Leu Trp Phe Phe
 360                 365                 370                 375

 tcc aag aga ttc aaa tct gct gcc atg tta gct gtc ttt gct gta tct     1206
 Ser Lys Arg Phe Lys Ser Ala Ala Met Leu Ala Val Phe Ala Val Ser
                 380                 385                 390

 gct gta gta cac gaa tat gcc ttg gct gtt tgc ttg agc ttt ttc tat     1254
 Ala Val Val His Glu Tyr Ala Leu Ala Val Cys Leu Ser Phe Phe Tyr
             395                 400                 405

 ccc gtg ctc ttc gtg ctc ttc atg ttc ttt gga atg gct ttc aac ttc     1302
 Pro Val Leu Phe Val Leu Phe Met Phe Phe Gly Met Ala Phe Asn Phe
         410                 415                 420

 att gtc aat gat agt cgg aaa aag ccg att tgg aat gtt ctg atg tgg     1350
 Ile Val Asn Asp Ser Arg Lys Lys Pro Ile Trp Asn Val Leu Met Trp
     425                 430                 435

 act tct ctt ttc ttg ggc aat gga gtc tta ctc tgc ttt tat tct caa     1398
 Thr Ser Leu Phe Leu Gly Asn Gly Val Leu Leu Cys Phe Tyr Ser Gln
 440                 445                 450                 455

 gaa tgg tat gca cgt cag cac tgt cct ctg aaa aat ccc aca ttt ttg     1446
 Glu Trp Tyr Ala Arg Gln His Cys Pro Leu Lys Asn Pro Thr Phe Leu
                 460                 465                 470

 gat tat gtc cgg cca cgt tcc tgg act tgt cgt tac gtg ttt tag         1491
 Asp Tyr Val Arg Pro Arg Ser Trp Thr Cys Arg Tyr Val Phe 
             475                 480                 485





      <210> 171
      <211> 4008
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (1)..(4008)

      <400> 171
  atg gag tcc gaa atg ctg caa tcg cct ctt ctg ggc ctg ggg gag gaa      48
  Met Glu Ser Glu Met Leu Gln Ser Pro Leu Leu Gly Leu Gly Glu Glu
    1               5                  10                  15

 gat gag gct gat ctt aca gac tgg aac cta cct ttg gct ttt atg aaa       96
 Asp Glu Ala Asp Leu Thr Asp Trp Asn Leu Pro Leu Ala Phe Met Lys
              20                  25                  30

 aag agg cac tgt gag aaa att gaa ggc tcc aaa tcc tta gct cag agc      144
 Lys Arg His Cys Glu Lys Ile Glu Gly Ser Lys Ser Leu Ala Gln Ser
          35                  40                  45

 tgg agg atg aag gat cgg atg aag aca gtc agt gtt gcc tta gtt ttg      192
 Trp Arg Met Lys Asp Arg Met Lys Thr Val Ser Val Ala Leu Val Leu
      50                  55                  60

 tgc ctg aat gtt ggt gtg gac cct ccc gat gtg gtg aag acc acg ccc      240
 Cys Leu Asn Val Gly Val Asp Pro Pro Asp Val Val Lys Thr Thr Pro
  65                  70                  75                  80

 tgt gca cgc ttg gaa tgc tgg atc gat cct ctg tcg atg ggt cct cag      288
 Cys Ala Arg Leu Glu Cys Trp Ile Asp Pro Leu Ser Met Gly Pro Gln
                  85                  90                  95

 aaa gct ctg gaa acc atc ggt gca aat tta cag aag cag tac gag aac      336
 Lys Ala Leu Glu Thr Ile Gly Ala Asn Leu Gln Lys Gln Tyr Glu Asn
             100                 105                 110

 tgg cag cca agg gcc cgg tac aag cag agc ctt gac cca act gtg gat      384
 Trp Gln Pro Arg Ala Arg Tyr Lys Gln Ser Leu Asp Pro Thr Val Asp
         115                 120                 125

 gaa gtc aag aag ctc tgc acg tcc tta cgt cgc aac gcc aag gag gag      432
 Glu Val Lys Lys Leu Cys Thr Ser Leu Arg Arg Asn Ala Lys Glu Glu
     130                 135                 140

 cga gtc ctc ttt cac tac aat ggc cac ggg gtg ccc cgg ccc aca gtc      480
 Arg Val Leu Phe His Tyr Asn Gly His Gly Val Pro Arg Pro Thr Val
 145                 150                 155                 160

 aac ggg gag gtc tgg gtc ttc aac aag aac tac acg cag tac atc cct      528
 Asn Gly Glu Val Trp Val Phe Asn Lys Asn Tyr Thr Gln Tyr Ile Pro
                 165                 170                 175

 ctg tcc ata tat gac ctg cag acg tgg atg ggc agc ccg tcg atc ttc      576
 Leu Ser Ile Tyr Asp Leu Gln Thr Trp Met Gly Ser Pro Ser Ile Phe
             180                 185                 190

 gtc tac gac tgc tcc aat gct ggc ttg atc gtc aag tcc ttc aag cag      624
 Val Tyr Asp Cys Ser Asn Ala Gly Leu Ile Val Lys Ser Phe Lys Gln
         195                 200                 205

 ttc gca cta cag cgg gag cag gag ctg gag gta gct gca atc aac cca      672
 Phe Ala Leu Gln Arg Glu Gln Glu Leu Glu Val Ala Ala Ile Asn Pro
     210                 215                 220

 aat cac cct ctt gct cag atg cct ttg cct ccg tcg atg aaa aac tgc      720
 Asn His Pro Leu Ala Gln Met Pro Leu Pro Pro Ser Met Lys Asn Cys
 225                 230                 235                 240

 atc cag ctg gca gcc tgc gag gcc acc gag ctg ctg ccc atg atc ccc      768
 Ile Gln Leu Ala Ala Cys Glu Ala Thr Glu Leu Leu Pro Met Ile Pro
                 245                 250                 255

 gac ctc ccg gct gac cta ttc acc tcc tgc ctc acc acc ccc atc aag      816
 Asp Leu Pro Ala Asp Leu Phe Thr Ser Cys Leu Thr Thr Pro Ile Lys
             260                 265                 270

 atc gcc ctg cgc tgg ttt tgc atg cag aaa tgt gtc agt ctg gtg cct      864
 Ile Ala Leu Arg Trp Phe Cys Met Gln Lys Cys Val Ser Leu Val Pro
         275                 280                 285

 ggc gtc aca ctg gat ttg ata gaa aag atc cct ggc cgc ctg aac gac      912
 Gly Val Thr Leu Asp Leu Ile Glu Lys Ile Pro Gly Arg Leu Asn Asp
     290                 295                 300

 agg agg acg ccc ctg ggt gaa ctg aac tgg atc ttc aca gcc atc aca      960
 Arg Arg Thr Pro Leu Gly Glu Leu Asn Trp Ile Phe Thr Ala Ile Thr
 305                 310                 315                 320

 gac acc atc gcg tgg aac gtg ctc ccc cgg gat ctc ttc caa aag ctc     1008
 Asp Thr Ile Ala Trp Asn Val Leu Pro Arg Asp Leu Phe Gln Lys Leu
                 325                 330                 335

 ttc aga cag gac ttg ctg gtg gct agt ctg ttt cga aat ttt tta ttg     1056
 Phe Arg Gln Asp Leu Leu Val Ala Ser Leu Phe Arg Asn Phe Leu Leu
             340                 345                 350

 gcg gaa agg att atg agg tcg tat aac tgc act ccc gtc agc agc ccg     1104
 Ala Glu Arg Ile Met Arg Ser Tyr Asn Cys Thr Pro Val Ser Ser Pro
         355                 360                 365

 cgt ctg ccg ccc acg tac atg cac gcc atg tgg caa gcc tgg gac ctg     1152
 Arg Leu Pro Pro Thr Tyr Met His Ala Met Trp Gln Ala Trp Asp Leu
     370                 375                 380

 gct gtt gac atc tgt ctg tct cag ctg ccg acg atc atc gag gaa ggc     1200
 Ala Val Asp Ile Cys Leu Ser Gln Leu Pro Thr Ile Ile Glu Glu Gly
 385                 390                 395                 400

 act gcg ttt cgg cac agc ccg ttc ttc gcc gag cag ctg acc gca ttc     1248
 Thr Ala Phe Arg His Ser Pro Phe Phe Ala Glu Gln Leu Thr Ala Phe
                 405                 410                 415

 cag gtg tgg ctc acc atg ggc gtg gag aac cga aac cca ccc gaa cag     1296
 Gln Val Trp Leu Thr Met Gly Val Glu Asn Arg Asn Pro Pro Glu Gln
             420                 425                 430

 ctg ccc atc gtc ctg cag gtg ctg tta agc caa gtg cac cgg ctg aga     1344
 Leu Pro Ile Val Leu Gln Val Leu Leu Ser Gln Val His Arg Leu Arg
         435                 440                 445

 gca ttg gac ttg ctt gga aga ttt ttg gac ctg ggt ccc tgg gca gtg     1392
 Ala Leu Asp Leu Leu Gly Arg Phe Leu Asp Leu Gly Pro Trp Ala Val
     450                 455                 460

 agc ctg gcc ttg tct gtc ggc atc ttc ccc tac gtg ctg aag ctg ctc     1440
 Ser Leu Ala Leu Ser Val Gly Ile Phe Pro Tyr Val Leu Lys Leu Leu
 465                 470                 475                 480

 cag agc tcg gcc cga gag ctg cgg cca ctt ctc gtt ttc atc tgg gcc     1488
 Gln Ser Ser Ala Arg Glu Leu Arg Pro Leu Leu Val Phe Ile Trp Ala
                 485                 490                 495

 aag atc ctc gca gtg gac agc tcg tgc cag gcg gac ctc gtg aag gac     1536
 Lys Ile Leu Ala Val Asp Ser Ser Cys Gln Ala Asp Leu Val Lys Asp
             500                 505                 510

 aac ggc cac aag tac ttc ctg tcg gtc ctg gcg gac ccc tac atg cca     1584
 Asn Gly His Lys Tyr Phe Leu Ser Val Leu Ala Asp Pro Tyr Met Pro
         515                 520                 525

 gct gaa cac cgg acc atg acg gct ttc att ctc gcc gtg atc gtc aac     1632
 Ala Glu His Arg Thr Met Thr Ala Phe Ile Leu Ala Val Ile Val Asn
     530                 535                 540

 agc tat cac acg ggg cag gaa gcc tgc ctt cag gga aac ctc att gcc     1680
 Ser Tyr His Thr Gly Gln Glu Ala Cys Leu Gln Gly Asn Leu Ile Ala
 545                 550                 555                 560

 atc tgc ctg gag cag ctc aac gac ccg cac ccc ttg ctg cgc cag tgg     1728
 Ile Cys Leu Glu Gln Leu Asn Asp Pro His Pro Leu Leu Arg Gln Trp
                 565                 570                 575

 gtg gcc atc tgc ctc ggc agg atc tgg cag aac ttc gac tcg gcg agg     1776
 Val Ala Ile Cys Leu Gly Arg Ile Trp Gln Asn Phe Asp Ser Ala Arg
             580                 585                 590

 tgg tgc ggc gtg agg gac agc gct cat gag aag ctc tac agc ctc ctc     1824
 Trp Cys Gly Val Arg Asp Ser Ala His Glu Lys Leu Tyr Ser Leu Leu
         595                 600                 605

 tcc gac ccc att ccc gag gtc cgc tgc gca gcg gtc ttc gcc ctt ggc     1872
 Ser Asp Pro Ile Pro Glu Val Arg Cys Ala Ala Val Phe Ala Leu Gly
     610                 615                 620

 acg ttc gtg ggc aac tct gca gag agg acg gac cac tcc acc acc atc     1920
 Thr Phe Val Gly Asn Ser Ala Glu Arg Thr Asp His Ser Thr Thr Ile
 625                 630                 635                 640

 gac cac aac gtg gcc atg atg ctg gcc cag ctg gtc agc gac ggg agc     1968
 Asp His Asn Val Ala Met Met Leu Ala Gln Leu Val Ser Asp Gly Ser
                 645                 650                 655

 ccc atg gtc cgg aag gag ctg gtg gtg gct ctg agt cat ctt gtg gtt     2016
 Pro Met Val Arg Lys Glu Leu Val Val Ala Leu Ser His Leu Val Val
             660                 665                 670

 cag tat gaa agc aat ttc tgc acc gtg gcc ctg cag ttc ata gaa gag     2064
 Gln Tyr Glu Ser Asn Phe Cys Thr Val Ala Leu Gln Phe Ile Glu Glu
         675                 680                 685

 gaa aag aac tac gcc ttg cct tct cca gca acc aca gag gga ggg agt     2112
 Glu Lys Asn Tyr Ala Leu Pro Ser Pro Ala Thr Thr Glu Gly Gly Ser
     690                 695                 700

 ttg acc cca gtg cga gac agc ccg tgc acc ccc aga ctt cgt tct gtg     2160
 Leu Thr Pro Val Arg Asp Ser Pro Cys Thr Pro Arg Leu Arg Ser Val
 705                 710                 715                 720

 agc tcc tat gga aac atc cgt gct gtc gcc aca gcc agg agc ctc aac     2208
 Ser Ser Tyr Gly Asn Ile Arg Ala Val Ala Thr Ala Arg Ser Leu Asn
                 725                 730                 735

 aaa tct ttg cag aac ctg agt ttg aca gag gaa tct ggt ggc gcg gtg     2256
 Lys Ser Leu Gln Asn Leu Ser Leu Thr Glu Glu Ser Gly Gly Ala Val
             740                 745                 750

 gcg ttc tcc ccc gga aac ctc agc acc agc agc agc gcc agc agc acc     2304
 Ala Phe Ser Pro Gly Asn Leu Ser Thr Ser Ser Ser Ala Ser Ser Thr
         755                 760                 765

 ctg ggc agc ccc gag aat gag gag cat atc ctg tcc ttc gag acc atc     2352
 Leu Gly Ser Pro Glu Asn Glu Glu His Ile Leu Ser Phe Glu Thr Ile
     770                 775                 780

 gac aag atg cgc cgc gcc agc tcc tac tcc tcc ctc aac tcc ctc atc     2400
 Asp Lys Met Arg Arg Ala Ser Ser Tyr Ser Ser Leu Asn Ser Leu Ile
 785                 790                 795                 800

 gga gtt tcc ttt aac agt gtt tac act cag att tgg aga gtc ctg ctg     2448
 Gly Val Ser Phe Asn Ser Val Tyr Thr Gln Ile Trp Arg Val Leu Leu
                 805                 810                 815

 cac ctg gct gct gac ccc tat cca gag gtc tcg gac gtg gcc atg aaa     2496
 His Leu Ala Ala Asp Pro Tyr Pro Glu Val Ser Asp Val Ala Met Lys
             820                 825                 830

 gta ctc aac agc atc gcc tac aag gcc acc gtg aac gcc cgg ccg cag     2544
 Val Leu Asn Ser Ile Ala Tyr Lys Ala Thr Val Asn Ala Arg Pro Gln
         835                 840                 845

 cgc gtc ctg gac acc tcc tcc ctc acg cag tcg gcc ccc gcc agc ccc     2592
 Arg Val Leu Asp Thr Ser Ser Leu Thr Gln Ser Ala Pro Ala Ser Pro
     850                 855                 860

 acc aac aag ggc gtg cac atc cac cag gcg ggg ggc tcc cct ccg gcg     2640
 Thr Asn Lys Gly Val His Ile His Gln Ala Gly Gly Ser Pro Pro Ala
 865                 870                 875                 880

 tcc agc acc agc agc tcc agc ctg acc aac gat gtg gcc aag cag ccg     2688
 Ser Ser Thr Ser Ser Ser Ser Leu Thr Asn Asp Val Ala Lys Gln Pro
                 885                 890                 895

 gtc agc cga gac ttg cct tct ggc cgg ccg ggc acc aca ggc ccc gct     2736
 Val Ser Arg Asp Leu Pro Ser Gly Arg Pro Gly Thr Thr Gly Pro Ala
             900                 905                 910

 ggg gcg cag tac acc cct cac tcc cac cag ttc ccc cgg aca cgg aag     2784
 Gly Ala Gln Tyr Thr Pro His Ser His Gln Phe Pro Arg Thr Arg Lys
         915                 920                 925

 atg ttc gac aag ggc cca gag cag act gcg gac gac gcg gac gat gct     2832
 Met Phe Asp Lys Gly Pro Glu Gln Thr Ala Asp Asp Ala Asp Asp Ala
     930                 935                 940

 gct gga cac aaa agt ttc atc tcc gcc acg gtg cag acg ggg ttc tgc     2880
 Ala Gly His Lys Ser Phe Ile Ser Ala Thr Val Gln Thr Gly Phe Cys
 945                 950                 955                 960

 gac tgg agc gcc cgc tat ttt gcc cag ccc gtc atg aag atc cca gaa     2928
 Asp Trp Ser Ala Arg Tyr Phe Ala Gln Pro Val Met Lys Ile Pro Glu
                 965                 970                 975

 gag cac gac ctg gag agt cag atc cgc aag gag cgg gag tgg cgg ttc     2976
 Glu His Asp Leu Glu Ser Gln Ile Arg Lys Glu Arg Glu Trp Arg Phe
             980                 985                 990

 ctg cga aac agc cgt gtc agg agg cag gcc cag caa gtc att cag aag     3024
 Leu Arg Asn Ser Arg Val Arg Arg Gln Ala Gln Gln Val Ile Gln Lys
         995                1000                1005

 ggc att acg aga ttg gac gac caa ata ttt ctg aac agg aac ccc ggc     3072
 Gly Ile Thr Arg Leu Asp Asp Gln Ile Phe Leu Asn Arg Asn Pro Gly
    1010                1015                1020

 gtc ccc tct gtg gtg aaa ttc cac ccc ttc acg ccg tgc atc gcc gta     3120
 Val Pro Ser Val Val Lys Phe His Pro Phe Thr Pro Cys Ile Ala Val
1025                1030                1035                1040

 gcc gac aag gac agc atc tgc ttt tgg gac tgg gag aaa ggg gag aag     3168
 Ala Asp Lys Asp Ser Ile Cys Phe Trp Asp Trp Glu Lys Gly Glu Lys
                1045                1050                1055

 ctg gat tat ttc cac aat ggg aac cct cgg tac acg agg gtc act gcc     3216
 Leu Asp Tyr Phe His Asn Gly Asn Pro Arg Tyr Thr Arg Val Thr Ala
            1060                1065                1070

 atg gag tat ctg aat ggc cag gac tgc tcg ctt ctg ctg acg gcc aca     3264
 Met Glu Tyr Leu Asn Gly Gln Asp Cys Ser Leu Leu Leu Thr Ala Thr
        1075                1080                1085

 gac gat ggt gcc atc agg gtc tgg aag aat ttt gct gat ttg gaa aag     3312
 Asp Asp Gly Ala Ile Arg Val Trp Lys Asn Phe Ala Asp Leu Glu Lys
    1090                1095                1100

 aac cca gag atg gtg acc gcg tgg cag ggg ctc tcg gac atg ctg cca     3360
 Asn Pro Glu Met Val Thr Ala Trp Gln Gly Leu Ser Asp Met Leu Pro
1105                1110                1115                1120

 acg acg cga gga gct ggg atg gtg gtg gac tgg gag cag gag acc ggc     3408
 Thr Thr Arg Gly Ala Gly Met Val Val Asp Trp Glu Gln Glu Thr Gly
                1125                1130                1135

 ctc ctc atg agc tca gga gac gtg cgg atc gtc cgg atc tgg gac aca     3456
 Leu Leu Met Ser Ser Gly Asp Val Arg Ile Val Arg Ile Trp Asp Thr
            1140                1145                1150

 gac cgt gag atg aag gtg cag gac atc cct acg ggc gca gac agc tgt     3504
 Asp Arg Glu Met Lys Val Gln Asp Ile Pro Thr Gly Ala Asp Ser Cys
        1155                1160                1165

 gtg acg agt ctg tcc tgt gat tcc cac cgc tca ctc atc gtg gct ggc     3552
 Val Thr Ser Leu Ser Cys Asp Ser His Arg Ser Leu Ile Val Ala Gly
    1170                1175                1180

 ctc ggt gac ggc tcc atc cgc gtc tac gac aga agg atg gca ctc agc     3600
 Leu Gly Asp Gly Ser Ile Arg Val Tyr Asp Arg Arg Met Ala Leu Ser
1185                1190                1195                1200

 gaa tgc cgc gtc atg acg tac cgg gag cac aca gcc tgg gtg gtg aag     3648
 Glu Cys Arg Val Met Thr Tyr Arg Glu His Thr Ala Trp Val Val Lys
                1205                1210                1215

 gcc tcc ctg cag aag cgt ccc gac ggc cac atc gtg agt gtg agc gtc     3696
 Ala Ser Leu Gln Lys Arg Pro Asp Gly His Ile Val Ser Val Ser Val
            1220                1225                1230

 aat gga gat gtg cgc atc ttt gat ccc cgg atg cct gag tcg gta aat     3744
 Asn Gly Asp Val Arg Ile Phe Asp Pro Arg Met Pro Glu Ser Val Asn
        1235                1240                1245

 gtg ctt cag atc gtg aag ggg ctg acg gcc ctg gac atc cac ccc cag     3792
 Val Leu Gln Ile Val Lys Gly Leu Thr Ala Leu Asp Ile His Pro Gln
    1250                1255                1260

 gcg gac ctg atc gca tgt ggc tcc gtc aat cag ttc acc gcc atc tac     3840
 Ala Asp Leu Ile Ala Cys Gly Ser Val Asn Gln Phe Thr Ala Ile Tyr
1265                1270                1275                1280

 aac agc agc gga gag ctc atc aac aac atc aag tac tac gac ggc ttc     3888
 Asn Ser Ser Gly Glu Leu Ile Asn Asn Ile Lys Tyr Tyr Asp Gly Phe
                1285                1290                1295

 atg ggc cag cgg gtc ggc gcc atc agc tgc ctg gcc ttc cac ccg cac     3936
 Met Gly Gln Arg Val Gly Ala Ile Ser Cys Leu Ala Phe His Pro His
            1300                1305                1310

 tgg cct cac ctg gcc gtg gga agc aac gac tac tac atc tcc gtg tac     3984
 Trp Pro His Leu Ala Val Gly Ser Asn Asp Tyr Tyr Ile Ser Val Tyr
        1315                1320                1325

 tcg gtg gag aag cgt gtc aga tag                                     4008
 Ser Val Glu Lys Arg Val Arg 
    1330                1335





      <210> 172
      <211> 1743
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (16)..(1743)

      <400> 172
 atgagctttt cagaa atg att tac tta caa att cca tat ttg aat gca gga      51
                  Met Ile Tyr Leu Gln Ile Pro Tyr Leu Asn Ala Gly
                    1               5                  10

 cag aat ctg gat agt atg ctt cat ggc act ggg atg aaa tca gac tcc       99
 Gln Asn Leu Asp Ser Met Leu His Gly Thr Gly Met Lys Ser Asp Ser
          15                  20                  25

 gac cag aaa aag tca gaa aat gga gta acc tta gca cca gag gat acc      147
 Asp Gln Lys Lys Ser Glu Asn Gly Val Thr Leu Ala Pro Glu Asp Thr
      30                  35                  40

 ttg cct ttt tta aag tgc tat tgc tca ggg cac tgt cca gat gat gct      195
 Leu Pro Phe Leu Lys Cys Tyr Cys Ser Gly His Cys Pro Asp Asp Ala
  45                  50                  55                  60

 att aat aac aca tgc ata act aat gga cat tgc ttt gcc atc ata gaa      243
 Ile Asn Asn Thr Cys Ile Thr Asn Gly His Cys Phe Ala Ile Ile Glu
                  65                  70                  75

 gaa gat gac cag gga gaa acc aca tta gct tca ggg tgt atg aaa tat      291
 Glu Asp Asp Gln Gly Glu Thr Thr Leu Ala Ser Gly Cys Met Lys Tyr
              80                  85                  90

 gaa gga tct gat ttt cag tgc aaa gat tct cca aaa gcc cag cta cgc      339
 Glu Gly Ser Asp Phe Gln Cys Lys Asp Ser Pro Lys Ala Gln Leu Arg
          95                 100                 105

 cgg aca ata gaa tgt tgt cgg acc aat tta tgt aac cag tat ttg caa      387
 Arg Thr Ile Glu Cys Cys Arg Thr Asn Leu Cys Asn Gln Tyr Leu Gln
     110                 115                 120

 ccc aca ctg ccc cct gtt gtc ata ggt ccg ttt ttt gat ggc agc att      435
 Pro Thr Leu Pro Pro Val Val Ile Gly Pro Phe Phe Asp Gly Ser Ile
 125                 130                 135                 140

 cga tgg ctg gtt ttg ctc att tct atg gct gtc tgc ata att gct atg      483
 Arg Trp Leu Val Leu Leu Ile Ser Met Ala Val Cys Ile Ile Ala Met
                 145                 150                 155

 atc atc ttc tcc agc tgc ttt tgt tac aaa ggt cat ctg ctg ttg cgt      531
 Ile Ile Phe Ser Ser Cys Phe Cys Tyr Lys Gly His Leu Leu Leu Arg
             160                 165                 170

 gtt att cac att aga gga cag ttg gaa agt gag ggg ggc gtg cct gtt      579
 Val Ile His Ile Arg Gly Gln Leu Glu Ser Glu Gly Gly Val Pro Val
         175                 180                 185

 gtc ctt aga cat tat tgc aag agc atc tca agc aga cgt cgt tac aat      627
 Val Leu Arg His Tyr Cys Lys Ser Ile Ser Ser Arg Arg Arg Tyr Asn
     190                 195                 200

 cgt gat ttg gaa cag gat gaa gca ttt att cca gtt gga gaa tca cta      675
 Arg Asp Leu Glu Gln Asp Glu Ala Phe Ile Pro Val Gly Glu Ser Leu
 205                 210                 215                 220

 aaa gac ctt att gac cag tca caa agt tct ggt agt ggg tct gga cta      723
 Lys Asp Leu Ile Asp Gln Ser Gln Ser Ser Gly Ser Gly Ser Gly Leu
                 225                 230                 235

 cct tta ttg gtt cag cga act att gcc aaa cag att cag atg gtc cgg      771
 Pro Leu Leu Val Gln Arg Thr Ile Ala Lys Gln Ile Gln Met Val Arg
             240                 245                 250

 caa gtt ggt aaa ggc cga tat gga gaa gta tgg atg ggc aaa tgg cgt      819
 Gln Val Gly Lys Gly Arg Tyr Gly Glu Val Trp Met Gly Lys Trp Arg
         255                 260                 265

 ggc gaa aaa gtg gcg gtg aaa gta ttc ttt acc act gaa gaa gcc agc      867
 Gly Glu Lys Val Ala Val Lys Val Phe Phe Thr Thr Glu Glu Ala Ser
     270                 275                 280

 tgg ttt cga gaa aca gaa atc tac caa act gtg cta atg cgc cat gaa      915
 Trp Phe Arg Glu Thr Glu Ile Tyr Gln Thr Val Leu Met Arg His Glu
 285                 290                 295                 300

 aac ata ctt ggt ttc ata gcg gca gac att aaa ggt aca ggt tcc tgg      963
 Asn Ile Leu Gly Phe Ile Ala Ala Asp Ile Lys Gly Thr Gly Ser Trp
                 305                 310                 315

 act cag ctc tat ttg att act gat tac cat gaa aat gga tct ctc tat     1011
 Thr Gln Leu Tyr Leu Ile Thr Asp Tyr His Glu Asn Gly Ser Leu Tyr
             320                 325                 330

 gac ttc ctg aaa tgt gct aca ctg gac acc aga gcc ctg ctt aaa ttg     1059
 Asp Phe Leu Lys Cys Ala Thr Leu Asp Thr Arg Ala Leu Leu Lys Leu
         335                 340                 345

 gct tat tca gct gcc tgt ggt ctg tgc cac ctg cac aca gaa att tat     1107
 Ala Tyr Ser Ala Ala Cys Gly Leu Cys His Leu His Thr Glu Ile Tyr
     350                 355                 360

 ggc acc caa gga aag ccc gca att gct cat cga gac cta aag agc aaa     1155
 Gly Thr Gln Gly Lys Pro Ala Ile Ala His Arg Asp Leu Lys Ser Lys
 365                 370                 375                 380

 aac atc ctc atc aag aaa aat ggg agt tgc tgc att gct gac ctg ggc     1203
 Asn Ile Leu Ile Lys Lys Asn Gly Ser Cys Cys Ile Ala Asp Leu Gly
                 385                 390                 395

 ctt gct gtt aaa ttc aac agt gac aca aat gaa gtt gat gtg ccc ttg     1251
 Leu Ala Val Lys Phe Asn Ser Asp Thr Asn Glu Val Asp Val Pro Leu
             400                 405                 410

 aat acc agg gtg ggc acc aaa cgc tac atg gct ccc gaa gtg ctg gac     1299
 Asn Thr Arg Val Gly Thr Lys Arg Tyr Met Ala Pro Glu Val Leu Asp
         415                 420                 425

 gaa agc ctg aac aaa aac cac ttc cag ccc tac atc atg gct gac atc     1347
 Glu Ser Leu Asn Lys Asn His Phe Gln Pro Tyr Ile Met Ala Asp Ile
     430                 435                 440

 tac agc ttc ggc cta atc att tgg gag atg gct cgt cgt tgt atc aca     1395
 Tyr Ser Phe Gly Leu Ile Ile Trp Glu Met Ala Arg Arg Cys Ile Thr
 445                 450                 455                 460

 gga ggg atc gtg gaa gaa tac caa ttg cca tat tac aac atg gta ccg     1443
 Gly Gly Ile Val Glu Glu Tyr Gln Leu Pro Tyr Tyr Asn Met Val Pro
                 465                 470                 475

 agt gat ccg tca tac gaa gat atg cgt gag gtt gtg tgt gtc aaa cgt     1491
 Ser Asp Pro Ser Tyr Glu Asp Met Arg Glu Val Val Cys Val Lys Arg
             480                 485                 490

 ttg cgg cca att gtg tct aat cgg tgg aac agt gat gaa gtg agt gga     1539
 Leu Arg Pro Ile Val Ser Asn Arg Trp Asn Ser Asp Glu Val Ser Gly
         495                 500                 505

 act cag tcc cct gaa gaa gtg att cgt aaa tgc cac caa ata tat tct     1587
 Thr Gln Ser Pro Glu Glu Val Ile Arg Lys Cys His Gln Ile Tyr Ser
     510                 515                 520

 ctg ctc act gaa cat ctc ttt act ttt cag tgt cta cga gca gtt ttg     1635
 Leu Leu Thr Glu His Leu Phe Thr Phe Gln Cys Leu Arg Ala Val Leu
 525                 530                 535                 540

 aag cta atg tca gaa tgc tgg gcc cac aat cca gcc tcc aga ctc aca     1683
 Lys Leu Met Ser Glu Cys Trp Ala His Asn Pro Ala Ser Arg Leu Thr
                 545                 550                 555

 gca ttg aga att aag aag acg ctt gcc aag atg gtt gaa tcc caa gat     1731
 Ala Leu Arg Ile Lys Lys Thr Leu Ala Lys Met Val Glu Ser Gln Asp
             560                 565                 570

 gta aaa atc tga                                                     1743
 Val Lys Ile 
         575





      <210> 173
      <211> 1929
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (16)..(1929)

      <400> 173
 atgagctttt cagaa atg att tac tta caa att cca tat ttg aat gca gga      51
                  Met Ile Tyr Leu Gln Ile Pro Tyr Leu Asn Ala Gly
                    1               5                  10

 cag aat ctg gat agt atg ctt cat ggc act ggg atg aaa tca gac tcc       99
 Gln Asn Leu Asp Ser Met Leu His Gly Thr Gly Met Lys Ser Asp Ser
          15                  20                  25

 gac cag aaa aag tca gaa aat gga gta acc tta gca cca gag gat acc      147
 Asp Gln Lys Lys Ser Glu Asn Gly Val Thr Leu Ala Pro Glu Asp Thr
      30                  35                  40

 ttg cct ttt tta aag tgc tat tgc tca ggg cac tgt cca gat gat gct      195
 Leu Pro Phe Leu Lys Cys Tyr Cys Ser Gly His Cys Pro Asp Asp Ala
  45                  50                  55                  60

 att aat aac aca tgc ata act aat gga cat tgc ttt gcc atc ata gaa      243
 Ile Asn Asn Thr Cys Ile Thr Asn Gly His Cys Phe Ala Ile Ile Glu
                  65                  70                  75

 gaa gat gac cag gga gaa acc aca tta gct tca ggg tgt atg aaa tat      291
 Glu Asp Asp Gln Gly Glu Thr Thr Leu Ala Ser Gly Cys Met Lys Tyr
              80                  85                  90

 gaa gga tct gat ttt cag tgc aaa gat tct cca aaa gcc cag cta cgc      339
 Glu Gly Ser Asp Phe Gln Cys Lys Asp Ser Pro Lys Ala Gln Leu Arg
          95                 100                 105

 cgg aca ata gaa tgt tgt cgg acc aat tta tgt aac cag tat ttg caa      387
 Arg Thr Ile Glu Cys Cys Arg Thr Asn Leu Cys Asn Gln Tyr Leu Gln
     110                 115                 120

 ccc aca ctg ccc cct gtt gtc ata ggt ccg ttt ttt gat ggc agc att      435
 Pro Thr Leu Pro Pro Val Val Ile Gly Pro Phe Phe Asp Gly Ser Ile
 125                 130                 135                 140

 cga tgg ctg gtt ttg ctc att tct atg gct gtc tgc ata att gct atg      483
 Arg Trp Leu Val Leu Leu Ile Ser Met Ala Val Cys Ile Ile Ala Met
                 145                 150                 155

 atc atc ttc tcc agc tgc ttt tgt tac aaa ggt cat ctg ctg ttg cgt      531
 Ile Ile Phe Ser Ser Cys Phe Cys Tyr Lys Gly His Leu Leu Leu Arg
             160                 165                 170

 gtt att cac att aga gga cag ttg gaa agt gag ggg ggc gtg cct gtt      579
 Val Ile His Ile Arg Gly Gln Leu Glu Ser Glu Gly Gly Val Pro Val
         175                 180                 185

 gtc ctt agg atc cta tgc cca caa gga gag agg aag gtg tca tct tct      627
 Val Leu Arg Ile Leu Cys Pro Gln Gly Glu Arg Lys Val Ser Ser Ser
     190                 195                 200

 cct ctt cct cag cat cag agg atc tta gcc tgg tca gag cac agg gag      675
 Pro Leu Pro Gln His Gln Arg Ile Leu Ala Trp Ser Glu His Arg Glu
 205                 210                 215                 220

 cat ttc ctc tac atc ccc aag agg cag agg gac ttt gct gct tct cct      723
 His Phe Leu Tyr Ile Pro Lys Arg Gln Arg Asp Phe Ala Ala Ser Pro
                 225                 230                 235

 ccc tcc aaa gta atg gat ctt tgc ctg tgc tct ggg gca ggg gga aga      771
 Pro Ser Lys Val Met Asp Leu Cys Leu Cys Ser Gly Ala Gly Gly Arg
             240                 245                 250

 gga cat tat tgc aag agc atc tca agc aga cgt cgt tac aat cgt gat      819
 Gly His Tyr Cys Lys Ser Ile Ser Ser Arg Arg Arg Tyr Asn Arg Asp
         255                 260                 265

 ttg gaa cag gat gaa gca ttt att cca gtt gga gaa tca cta aaa gac      867
 Leu Glu Gln Asp Glu Ala Phe Ile Pro Val Gly Glu Ser Leu Lys Asp
     270                 275                 280

 ctt att gac cag tca caa agt tct ggt agt ggg tct gga cta cct tta      915
 Leu Ile Asp Gln Ser Gln Ser Ser Gly Ser Gly Ser Gly Leu Pro Leu
 285                 290                 295                 300

 ttg gtt cag cga act att gcc aaa cag att cag atg gtc cgg caa gtt      963
 Leu Val Gln Arg Thr Ile Ala Lys Gln Ile Gln Met Val Arg Gln Val
                 305                 310                 315

 ggt aaa ggc cga tat gga gaa gta tgg atg ggc aaa tgg cgt ggc gaa     1011
 Gly Lys Gly Arg Tyr Gly Glu Val Trp Met Gly Lys Trp Arg Gly Glu
             320                 325                 330

 aaa gtg gcg gtg aaa gta ttc ttt acc act gaa gaa gcc agc tgg ttt     1059
 Lys Val Ala Val Lys Val Phe Phe Thr Thr Glu Glu Ala Ser Trp Phe
         335                 340                 345

 cga gaa aca gaa atc tac caa act gtg cta atg cgc cat gaa aac ata     1107
 Arg Glu Thr Glu Ile Tyr Gln Thr Val Leu Met Arg His Glu Asn Ile
     350                 355                 360

 ctt ggt ttc ata gcg gca gac att aaa ggt aca ggt tcc tgg act cag     1155
 Leu Gly Phe Ile Ala Ala Asp Ile Lys Gly Thr Gly Ser Trp Thr Gln
 365                 370                 375                 380

 ctc tat ttg att act gat tac cat gaa aat gga tct ctc tat gac ttc     1203
 Leu Tyr Leu Ile Thr Asp Tyr His Glu Asn Gly Ser Leu Tyr Asp Phe
                 385                 390                 395

 ctg aaa tgt gct aca ctg gac acc aga gcc ctg ctt aaa ttg gct tat     1251
 Leu Lys Cys Ala Thr Leu Asp Thr Arg Ala Leu Leu Lys Leu Ala Tyr
             400                 405                 410

 tca gct gcc tgt ggt ctg tgc cac ctg cac aca gaa att tat ggc acc     1299
 Ser Ala Ala Cys Gly Leu Cys His Leu His Thr Glu Ile Tyr Gly Thr
         415                 420                 425

 caa gga aag ccc gca att gct cat cga gac cta aag agc aaa aac atc     1347
 Gln Gly Lys Pro Ala Ile Ala His Arg Asp Leu Lys Ser Lys Asn Ile
     430                 435                 440

 ctc atc aag aaa aat ggg agt tgc tgc att gct gac ctg ggc ctt gct     1395
 Leu Ile Lys Lys Asn Gly Ser Cys Cys Ile Ala Asp Leu Gly Leu Ala
 445                 450                 455                 460

 gtt aaa ttc aac agt gac aca aat gaa gtt gat gtg ccc ttg aat acc     1443
 Val Lys Phe Asn Ser Asp Thr Asn Glu Val Asp Val Pro Leu Asn Thr
                 465                 470                 475

 agg gtg ggc acc aaa cgc tac atg gct ccc gaa gtg ctg gac gaa agc     1491
 Arg Val Gly Thr Lys Arg Tyr Met Ala Pro Glu Val Leu Asp Glu Ser
             480                 485                 490

 ctg aac aaa aac cac ttc cag ccc tac atc atg gct gac atc tac agc     1539
 Leu Asn Lys Asn His Phe Gln Pro Tyr Ile Met Ala Asp Ile Tyr Ser
         495                 500                 505

 ttc ggc cta atc att tgg gag atg gct cgt cgt tgt atc aca gga ggg     1587
 Phe Gly Leu Ile Ile Trp Glu Met Ala Arg Arg Cys Ile Thr Gly Gly
     510                 515                 520

 atc gtg gaa gaa tac caa ttg cca tat tac aac atg gta ccg agt gat     1635
 Ile Val Glu Glu Tyr Gln Leu Pro Tyr Tyr Asn Met Val Pro Ser Asp
 525                 530                 535                 540

 ccg tca tac gaa gat atg cgt gag gtt gtg tgt gtc aaa cgt ttg cgg     1683
 Pro Ser Tyr Glu Asp Met Arg Glu Val Val Cys Val Lys Arg Leu Arg
                 545                 550                 555

 cca att gtg tct aat cgg tgg aac agt gat gaa gtg agt gga act cag     1731
 Pro Ile Val Ser Asn Arg Trp Asn Ser Asp Glu Val Ser Gly Thr Gln
             560                 565                 570

 tcc cct gaa gaa gtg att cgt aaa tgc cac caa ata tat tct ctg ctc     1779
 Ser Pro Glu Glu Val Ile Arg Lys Cys His Gln Ile Tyr Ser Leu Leu
         575                 580                 585

 act gaa cat ctc ttt act ttt cag tgt cta cga gca gtt ttg aag cta     1827
 Thr Glu His Leu Phe Thr Phe Gln Cys Leu Arg Ala Val Leu Lys Leu
     590                 595                 600

 atg tca gaa tgc tgg gcc cac aat cca gcc tcc aga ctc aca gca ttg     1875
 Met Ser Glu Cys Trp Ala His Asn Pro Ala Ser Arg Leu Thr Ala Leu
 605                 610                 615                 620

 aga att aag aag acg ctt gcc aag atg gtt gaa tcc caa gat gta aaa     1923
 Arg Ile Lys Lys Thr Leu Ala Lys Met Val Glu Ser Gln Asp Val Lys
                 625                 630                 635

 atc tga                                                             1929
 Ile 






      <210> 174
      <211> 1602
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (1)..(1602)

      <400> 174
  atg tac cag ccc aac act ctg gat ccc atc ttt ggc atg atg ttt gaa      48
  Met Tyr Gln Pro Asn Thr Leu Asp Pro Ile Phe Gly Met Met Phe Glu
    1               5                  10                  15

 ctc acc tgc aac ata ccc ctg gag aag gac cta gag atc cag ctc tat       96
 Leu Thr Cys Asn Ile Pro Leu Glu Lys Asp Leu Glu Ile Gln Leu Tyr
              20                  25                  30

 gac ttc gac cta ttt tca cct gat gat aag ata gga acc aca gtc atc      144
 Asp Phe Asp Leu Phe Ser Pro Asp Asp Lys Ile Gly Thr Thr Val Ile
          35                  40                  45

 gac ctt gaa aac cga ctc cta tct ggc ttt gga gct cat tgt ggg ctc      192
 Asp Leu Glu Asn Arg Leu Leu Ser Gly Phe Gly Ala His Cys Gly Leu
      50                  55                  60

 tcc aaa tcc tac tgc cag tca ggg ccc ttt aga tgg cgg gat cag atg      240
 Ser Lys Ser Tyr Cys Gln Ser Gly Pro Phe Arg Trp Arg Asp Gln Met
  65                  70                  75                  80

 ccc cca agc tac ctc cta gaa cgc tat gcc aag cgg aaa ggg cta cct      288
 Pro Pro Ser Tyr Leu Leu Glu Arg Tyr Ala Lys Arg Lys Gly Leu Pro
                  85                  90                  95

 ccg cct ctg ttc agt cct gag gaa gat gct gtt ttc tat aat ggg aaa      336
 Pro Pro Leu Phe Ser Pro Glu Glu Asp Ala Val Phe Tyr Asn Gly Lys
             100                 105                 110

 aag ttc aag ctg caa agc ttt gag ccc aaa acc cct act gtc cat ggt      384
 Lys Phe Lys Leu Gln Ser Phe Glu Pro Lys Thr Pro Thr Val His Gly
         115                 120                 125

 ttg gga ccc aag aag gaa cgc ctt gca ctg tac ctc ctg cac acc cag      432
 Leu Gly Pro Lys Lys Glu Arg Leu Ala Leu Tyr Leu Leu His Thr Gln
     130                 135                 140

 ggg ctg gta cct gag cac gtg gag acc cgc aca ctg tac agc cac agc      480
 Gly Leu Val Pro Glu His Val Glu Thr Arg Thr Leu Tyr Ser His Ser
 145                 150                 155                 160

 cag cca ggc atc gac cag gga aag gtg caa atg tgg gtg gac atc ttc      528
 Gln Pro Gly Ile Asp Gln Gly Lys Val Gln Met Trp Val Asp Ile Phe
                 165                 170                 175

 ccc aag aag ctg ggg cct cct ggc ccc caa gtc aac atc aac ccc aga      576
 Pro Lys Lys Leu Gly Pro Pro Gly Pro Gln Val Asn Ile Asn Pro Arg
             180                 185                 190

 aag cct aaa cgg tat gag ctg cga tgc atc atc tgg aag act gcc aat      624
 Lys Pro Lys Arg Tyr Glu Leu Arg Cys Ile Ile Trp Lys Thr Ala Asn
         195                 200                 205

 gtg gac ctg gtg gat gac aat tta agt aga gag aag acg agc gac atc      672
 Val Asp Leu Val Asp Asp Asn Leu Ser Arg Glu Lys Thr Ser Asp Ile
     210                 215                 220

 tac atc aaa ggg tgg tta tac ggg ctg gag aag gac atg cag aag aca      720
 Tyr Ile Lys Gly Trp Leu Tyr Gly Leu Glu Lys Asp Met Gln Lys Thr
 225                 230                 235                 240

 gac atc cac tac cac tcg ctg act ggg gag gcc gac ttc aac tgg cgg      768
 Asp Ile His Tyr His Ser Leu Thr Gly Glu Ala Asp Phe Asn Trp Arg
                 245                 250                 255

 ttc atc ttt acc atg gac tac ctg gcg gcg gag cgc acg tgt gtc cag      816
 Phe Ile Phe Thr Met Asp Tyr Leu Ala Ala Glu Arg Thr Cys Val Gln
             260                 265                 270

 agc cag aag gat tac ata tgg agc ctg gat gcc acg tcc atg aag ttc      864
 Ser Gln Lys Asp Tyr Ile Trp Ser Leu Asp Ala Thr Ser Met Lys Phe
         275                 280                 285

 cca gcc cga ctt atc atc cag gtc tgg gac aat gac atc ttc tcc ccc      912
 Pro Ala Arg Leu Ile Ile Gln Val Trp Asp Asn Asp Ile Phe Ser Pro
     290                 295                 300

 gac gac ttc cta ggg gtc ctg gag ctg gat ttg tct gac atg ccc ctc      960
 Asp Asp Phe Leu Gly Val Leu Glu Leu Asp Leu Ser Asp Met Pro Leu
 305                 310                 315                 320

 ccg gct cgg cac gcc aag cag tgc tcc atc agg atg atg gac gcc gac     1008
 Pro Ala Arg His Ala Lys Gln Cys Ser Ile Arg Met Met Asp Ala Asp
                 325                 330                 335

 ccc aag tgg ccc tat ttc atc caa tac aag cac ttc tcc ctc ttt aag     1056
 Pro Lys Trp Pro Tyr Phe Ile Gln Tyr Lys His Phe Ser Leu Phe Lys
             340                 345                 350

 aag aag act gtg act ggc tgg tgg cct tgc cag gtc ctc gat ggt ggc     1104
 Lys Lys Thr Val Thr Gly Trp Trp Pro Cys Gln Val Leu Asp Gly Gly
         355                 360                 365

 aaa tgg cgc ttg tcg ggc aag gtg aag atg agc ctg gag att ctg tca     1152
 Lys Trp Arg Leu Ser Gly Lys Val Lys Met Ser Leu Glu Ile Leu Ser
     370                 375                 380

 gag aag gaa gcc tta atc aag cca gcc ggg cga ggc cag tcg gaa ccc     1200
 Glu Lys Glu Ala Leu Ile Lys Pro Ala Gly Arg Gly Gln Ser Glu Pro
 385                 390                 395                 400

 aac cag tac ccc aca ctt cat cct ccc cta cgc acc aac acc tct ttc     1248
 Asn Gln Tyr Pro Thr Leu His Pro Pro Leu Arg Thr Asn Thr Ser Phe
                 405                 410                 415

 acg tgg ctg cgg tca cca gtt caa aac ttc tgc tat att ttc tgg aaa     1296
 Thr Trp Leu Arg Ser Pro Val Gln Asn Phe Cys Tyr Ile Phe Trp Lys
             420                 425                 430

 cgc tat cgc ttc aaa ctc ata gcc ttt atg gtc ata tcg att ata gca     1344
 Arg Tyr Arg Phe Lys Leu Ile Ala Phe Met Val Ile Ser Ile Ile Ala
         435                 440                 445

 ctt atg ctg ttt aac ttc atc tat tca gct ccg cac tat ttg gcc atg     1392
 Leu Met Leu Phe Asn Phe Ile Tyr Ser Ala Pro His Tyr Leu Ala Met
     450                 455                 460

 agc tgg atc aaa cct caa ctt cag ctg tat cct ccc att aaa ata ttc     1440
 Ser Trp Ile Lys Pro Gln Leu Gln Leu Tyr Pro Pro Ile Lys Ile Phe
 465                 470                 475                 480

 aat atc atc aat tca cta aac acc agc aac gcc agc tct tcc atc ctt     1488
 Asn Ile Ile Asn Ser Leu Asn Thr Ser Asn Ala Ser Ser Ser Ile Leu
                 485                 490                 495

 ccc acc cag gat cca aac cta aag cct aca ata gac cat gag tgg aaa     1536
 Pro Thr Gln Asp Pro Asn Leu Lys Pro Thr Ile Asp His Glu Trp Lys
             500                 505                 510

 ctc cac cca gga ccc aca aat cac ctg agt gat att ttc cca gaa ctt     1584
 Leu His Pro Gly Pro Thr Asn His Leu Ser Asp Ile Phe Pro Glu Leu
         515                 520                 525

 cca gcc cca gga gac taa                                             1602
 Pro Ala Pro Gly Asp 
     530





      <210> 175
      <211> 5677
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (3269)..(5677)

      <400> 175
 gatctctccc atgaagtgac caggatagag aagcaccaga accgccaaaa gtatgggctg     60

 tgcgtcatct tcctttcctg taccatgatg cccaacttta aagagctgat ccatttcgag    120

 gtcagcatcg gtcactatgg gaacaagatg gacctgaatt acaagcctct agtctcaagc    180

 acaccgtaca gcccagtgat atatgatggg aacatctacc attatgtgcc ctggtacaac    240

 accaagcctg tcgtggccgt gacctccaac tgggaggacg tcagcttccg catgaactgc    300

 ctcaacctcc tccacttcac tcgggaccgc ctgaaagcca acctggacac cctgaaatcc    360

 acgcggaatc cgaaggatcc agctctcctc taccagtggg agaaactgct gagggagctg    420

 gcagaggact gcaagcgccc tctgccctgc atgacctatc agcccaaagc caccagcctg    480

 gacaggaaga ggtggcagct ccgcagcctc ctcctgcagg aactggccca aaaggccaag    540

 caagccaagc ccaaggacat ggtggccaca gcggaggact ggctgtaccg cctcaacgcc    600

 gtgctccctg agccccagat gggcctccct gacgtgatga tttggctggt ggccaaggag    660

 cagcgagtgg cctatgcaca gtacccagag ggtgaaggac agaaggatgt gctcccagct    720

 cacctccggg tctgcatgtg gcttggcaat gtcacagaca gcaaggacct gcagctgctc    780

 cgccagggtg acacagcggt gtacgccgag atggtgagtg tatgagaatc aggccaagta    840

 taaagaccag tgggggcagc aggggctgta tcactgcccc aacttctcgg atgtcatggg    900

 gaacaagacc ctccccatga cggatttcca accacccctg ggatggcact ggcaggacag    960

 ctggacagtg gaacctcaga gaaggctcct cctggacata gacatcaaca agagccaggt   1020

 gctggaggag gtatatgaga accagggccg tgacaccaga ggggcctggg ggcctgccgc   1080

 catcccaaac acagacgtga atggacagcc catggaggcc cgggagaacg tgaagtgccc   1140

 ccaaggctgg cactttaaga aggactgggt ggtggagctg aaccacgcag tggacagtaa   1200

 gggctgggag tatggagtgg ggatcccacc gtcgggcctg ccccaggtct ggagcccggt   1260

 ggagaagacc taccactcgt gccgccgccg gcgctgggcg cgtgtgcgct tcaggaacca   1320

 tggggagctg agccacgagc aggagaccct ctccttcctg cagctgggcc tggccaaggg   1380

 cgaggaggag ggctgggagt atgacacctt cggctccaag ttccacctca accctcagcc   1440

 ccagagccgg ttccgccgcc gctgctggcg ccgcaggctg gcccccaaca aggacaaggg   1500

 catcgcgccc atattcctcc tggaggggtc cttggctatg gatctgaaat accacgctgg   1560

 gaaggaagag gacagcaaga catggccatg gggtctggac agacagttca gggaccccca   1620

 gaggcaggac acccggcccc ccaacttgcc cttcatctac tgcaccttca ataagcccca   1680

 ctactaccag ctcttctgct acatctacca ggcccggaac ctggtgtcca atcagatcct   1740

 gacattccaa gggcccttca ttcgggtggt cttcctgaac cacagccagt gcacccaaac   1800

 cctgaggagc tctgcaggcc ccacatgggc ccagacactc atcttccagc acctccttct   1860

 gtacgagaac ccgcaggaca ccaaagagag cccaccgctt gtggtgctgg agctgtggca   1920

 gcgtgacttc tggggcaagg agagcttgtg gggacggagc gtgtggcccc caatggtctg   1980

 gctggatctc caggaccgga tcctgccccc catgaggtgg catccccttg taaaggagtt   2040

 ggggaaggaa gagggcgaga tcttggcatc ctgtgagctg atcctccaga ctgagaagct   2100

 tggagagaag cagctgccta tcttaagcgt tccctggaag aatggggcat acacactccc   2160

 caagagcatc cagcccacga taaagaggat ggccattgag gtgctggcga tgtgggatgg   2220

 ggacggtggg caggacaggc gggggtggtc tggagtgcgc tgcagccttc tgctggtcct   2280

 ccctgactac tggatccaaa gctcacaccc cgaaaaagac tacctgggag gtggagggag   2340

 acaggagaga aacgaagagg ttctggtgta acactggaaa tcattttacc acaaacctct   2400

 gcagtgagga gtaggcaaag ggctgtagca tgcatgatca cttgtgggac tcacgctgcc   2460

 cctgcgcagt agcaactact ttgcagagaa ggaaatagag gctccaagag ataacacatt   2520

 ccacgcacag tgatgcaggg actaactgac agggccattt aggcccagcc ctgtctgact   2580

 gcagatgcca ggatgttgct cacctctctt ctgagagtag catgagggtc ctcattcaga   2640

 agctgtgtgc cctgccgcaa atgtggcaaa gagcacaaga cggtcaggcc tctgggactg   2700

 aaggcttccc caagatcagg caacttggct ggttcccgct ttaggccccg aggaggccca   2760

 aagtcagggt gcagctattt cctggcagga tgccaggtca ctgaatggcc atggggtcct   2820

 caatgagcta gacggcacag gggccctgag aaatccaggc acttcctgct tcttcaggcc   2880

 tcagaggcag tcggcttcag gaactcctac ctgagaactg atgaggccag acaaggcagc   2940

 gggtgaggag gggcaatgcc tgcgggctat ggaggtcagt ggaggatgca gccagtggcc   3000

 agaggtcacc tccctcatgg gttgggggac agcgtcccag ccccgagggc aagcactgat   3060

 ccctcacagg acggggaagc ctgtccttgt gcgccttcag acactggctc ctctgcagcc   3120

 ccattccctg gccctgcagg ctcctgctgc accgctattg cccctcagcc cccttctctg   3180

 gccaggaccc cattacagag gcgctgcctg ccccttgtcc tgccctcctt ctttgttctg   3240

 gtagatcctg gcctggggcc ttcggaac   atg aag aag gcg agc tcc ccc cag    3292
                                  Met Lys Lys Ala Ser Ser Pro Gln
                                    1               5

 ctc ctg gtg gaa ttc ggg gaa gag tcc ctg agg aca gaa ccc atc agg     3340
 Leu Leu Val Glu Phe Gly Glu Glu Ser Leu Arg Thr Glu Pro Ile Arg
      10                  15                  20

 gac ttt cag acc aac ccc aac ttc ccc gag tct gag tct gtc cta gtc     3388
 Asp Phe Gln Thr Asn Pro Asn Phe Pro Glu Ser Glu Ser Val Leu Val
  25                  30                  35                  40

 ctc aca gtg ctc atg ccg acg gag gag gcc tat gca ctg ccc ctc gtg     3436
 Leu Thr Val Leu Met Pro Thr Glu Glu Ala Tyr Ala Leu Pro Leu Val
                  45                  50                  55

 gtg aag gtg gta gac aac tgg gcc ttc ggc cag cag acc gtg acg ggc     3484
 Val Lys Val Val Asp Asn Trp Ala Phe Gly Gln Gln Thr Val Thr Gly
              60                  65                  70

 cag gcc aac atc gac ttc ctc cag ccc tac ttc tgt gac ccc tgg gct     3532
 Gln Ala Asn Ile Asp Phe Leu Gln Pro Tyr Phe Cys Asp Pro Trp Ala
          75                  80                  85

 caa gac tat atg cac cca aag ctt cca acg ctg tct gag aag aag cac     3580
 Gln Asp Tyr Met His Pro Lys Leu Pro Thr Leu Ser Glu Lys Lys His
      90                  95                 100

 caa gac ttc cta ggc tac ctc tac aga aag ttc tgg ttc aag tcc agt     3628
 Gln Asp Phe Leu Gly Tyr Leu Tyr Arg Lys Phe Trp Phe Lys Ser Ser
 105                 110                 115                 120

 aaa gca gag gat gag tat gag cat gag gtg gac tgg tgg agc aag ctg     3676
 Lys Ala Glu Asp Glu Tyr Glu His Glu Val Asp Trp Trp Ser Lys Leu
                 125                 130                 135

 ttc tgg gcc aca gat gag cac aag tcc ctg aag tac aag tac aaa gac     3724
 Phe Trp Ala Thr Asp Glu His Lys Ser Leu Lys Tyr Lys Tyr Lys Asp
             140                 145                 150

 tac cac acc ctc aag gtg tat gag tgt gag ctg gag gcc gtg cca gcc     3772
 Tyr His Thr Leu Lys Val Tyr Glu Cys Glu Leu Glu Ala Val Pro Ala
         155                 160                 165

 ttc cag ggc ctg cag gac ttc tgc cag acc ttc aaa ctc tac cag gag     3820
 Phe Gln Gly Leu Gln Asp Phe Cys Gln Thr Phe Lys Leu Tyr Gln Glu
     170                 175                 180

 cag ccc aag ttg gac agc ccc gtg gta ggg gag ttc aag ggc ctt ttc     3868
 Gln Pro Lys Leu Asp Ser Pro Val Val Gly Glu Phe Lys Gly Leu Phe
 185                 190                 195                 200

 cgc atc tac ccc ttt cct gag aat cca gaa gcc cca aag ccc ccg ctg     3916
 Arg Ile Tyr Pro Phe Pro Glu Asn Pro Glu Ala Pro Lys Pro Pro Leu
                 205                 210                 215

 cag ttc ttg gtt tgg cca gag aga gag gac ttc ccc cag ccg tgc ttg     3964
 Gln Phe Leu Val Trp Pro Glu Arg Glu Asp Phe Pro Gln Pro Cys Leu
             220                 225                 230

 gtg cgg gtg tac atg gta cga gcc atc aac ctg cag ccc cag gac tac     4012
 Val Arg Val Tyr Met Val Arg Ala Ile Asn Leu Gln Pro Gln Asp Tyr
         235                 240                 245

 aat ggc ctg tgt gac cct tat gtg atc ctg aaa ctg ggc aag aca gag     4060
 Asn Gly Leu Cys Asp Pro Tyr Val Ile Leu Lys Leu Gly Lys Thr Glu
     250                 255                 260

 ctt ggc aac cgg gac atg tac cag ccc aac act ctg gat ccc atc ttt     4108
 Leu Gly Asn Arg Asp Met Tyr Gln Pro Asn Thr Leu Asp Pro Ile Phe
 265                 270                 275                 280

 ggc atg atg ttt gaa ctc acc tgc aac ata ccc ctg gag aag gac cta     4156
 Gly Met Met Phe Glu Leu Thr Cys Asn Ile Pro Leu Glu Lys Asp Leu
                 285                 290                 295

 gag atc cag ctc tat gac ttc gac cta ttt tca cct gat gat aag ata     4204
 Glu Ile Gln Leu Tyr Asp Phe Asp Leu Phe Ser Pro Asp Asp Lys Ile
             300                 305                 310

 gga acc aca gtc atc gac ctt gaa aac cga ctc cta tct ggc ttt gga     4252
 Gly Thr Thr Val Ile Asp Leu Glu Asn Arg Leu Leu Ser Gly Phe Gly
         315                 320                 325

 gct cat tgt ggg ctc tcc aaa tcc tac tgc cag tca ggg ccc ttt aga     4300
 Ala His Cys Gly Leu Ser Lys Ser Tyr Cys Gln Ser Gly Pro Phe Arg
     330                 335                 340

 tgg cgg gat cag atg ccc cca agc tac ctc cta gaa cgc tat gcc aag     4348
 Trp Arg Asp Gln Met Pro Pro Ser Tyr Leu Leu Glu Arg Tyr Ala Lys
 345                 350                 355                 360

 cgg aaa ggg cta cct ccg cct ctg ttc agt cct gag gaa gat gct gtt     4396
 Arg Lys Gly Leu Pro Pro Pro Leu Phe Ser Pro Glu Glu Asp Ala Val
                 365                 370                 375

 ttc tat aat ggg aaa aag ttc aag ctg caa agc ttt gag ccc aaa acc     4444
 Phe Tyr Asn Gly Lys Lys Phe Lys Leu Gln Ser Phe Glu Pro Lys Thr
             380                 385                 390

 cct act gtc cat ggt ttg gga ccc aag aag gaa cgc ctt gca ctg tac     4492
 Pro Thr Val His Gly Leu Gly Pro Lys Lys Glu Arg Leu Ala Leu Tyr
         395                 400                 405

 ctc ctg cac acc cag ggg ctg gta cct gag cac gtg gag acc cgc aca     4540
 Leu Leu His Thr Gln Gly Leu Val Pro Glu His Val Glu Thr Arg Thr
     410                 415                 420

 ctg tac agc cac agc cag cca ggc atc gac cag gga aag gtg caa atg     4588
 Leu Tyr Ser His Ser Gln Pro Gly Ile Asp Gln Gly Lys Val Gln Met
 425                 430                 435                 440

 tgg gtg gac atc ttc ccc aag aag ctg ggg cct cct ggc ccc caa gtc     4636
 Trp Val Asp Ile Phe Pro Lys Lys Leu Gly Pro Pro Gly Pro Gln Val
                 445                 450                 455

 aac atc aac ccc aga aag cct aaa cgg tat gag ctg cga tgc atc atc     4684
 Asn Ile Asn Pro Arg Lys Pro Lys Arg Tyr Glu Leu Arg Cys Ile Ile
             460                 465                 470

 tgg aag act gcc aat gtg gac ctg gtg gat gac aat tta agt aga gag     4732
 Trp Lys Thr Ala Asn Val Asp Leu Val Asp Asp Asn Leu Ser Arg Glu
         475                 480                 485

 aag acg agc gac atc tac atc aaa ggg tgg tta tac ggg ctg gag aag     4780
 Lys Thr Ser Asp Ile Tyr Ile Lys Gly Trp Leu Tyr Gly Leu Glu Lys
     490                 495                 500

 gac atg cag aag aca gac atc cac tac cac tcg ctg act ggg gag gcc     4828
 Asp Met Gln Lys Thr Asp Ile His Tyr His Ser Leu Thr Gly Glu Ala
 505                 510                 515                 520

 gac ttc aac tgg cgg ttc atc ttt acc atg gac tac ctg gcg gcg gag     4876
 Asp Phe Asn Trp Arg Phe Ile Phe Thr Met Asp Tyr Leu Ala Ala Glu
                 525                 530                 535

 cgc acg tgt gtc cag agc cag aag gat tac ata tgg agc ctg gat gcc     4924
 Arg Thr Cys Val Gln Ser Gln Lys Asp Tyr Ile Trp Ser Leu Asp Ala
             540                 545                 550

 acg tcc atg aag ttc cca gcc cga ctt atc atc cag gtc tgg gac aat     4972
 Thr Ser Met Lys Phe Pro Ala Arg Leu Ile Ile Gln Val Trp Asp Asn
         555                 560                 565

 gac atc ttc tcc ccc gac gac ttc cta ggg gtc ctg gag ctg gat ttg     5020
 Asp Ile Phe Ser Pro Asp Asp Phe Leu Gly Val Leu Glu Leu Asp Leu
     570                 575                 580

 tct gac atg ccc ctc ccg gct cgg cac gcc aag cag tgc tcc atc agg     5068
 Ser Asp Met Pro Leu Pro Ala Arg His Ala Lys Gln Cys Ser Ile Arg
 585                 590                 595                 600

 atg atg gac gcc gac ccc aag tgg ccc tat ttc atc caa tac aag cac     5116
 Met Met Asp Ala Asp Pro Lys Trp Pro Tyr Phe Ile Gln Tyr Lys His
                 605                 610                 615

 ttc tcc ctc ttt aag aag aag act gtg act ggc tgg tgg cct tgc cag     5164
 Phe Ser Leu Phe Lys Lys Lys Thr Val Thr Gly Trp Trp Pro Cys Gln
             620                 625                 630

 gtc ctc gat ggt ggc aaa tgg cgc ttg tcg ggc aag gtg aag atg agc     5212
 Val Leu Asp Gly Gly Lys Trp Arg Leu Ser Gly Lys Val Lys Met Ser
         635                 640                 645

 ctg gag att ctg tca gag aag gaa gcc tta atc aag cca gcc ggg cga     5260
 Leu Glu Ile Leu Ser Glu Lys Glu Ala Leu Ile Lys Pro Ala Gly Arg
     650                 655                 660

 ggc cag tcg gaa ccc aac cag tac ccc aca ctt cat cct ccc cta cgc     5308
 Gly Gln Ser Glu Pro Asn Gln Tyr Pro Thr Leu His Pro Pro Leu Arg
 665                 670                 675                 680

 acc aac acc tct ttc acg tgg ctg cgg tca cca gtt caa aac ttc tgc     5356
 Thr Asn Thr Ser Phe Thr Trp Leu Arg Ser Pro Val Gln Asn Phe Cys
                 685                 690                 695

 tat att ttc tgg aaa cgc tat cgc ttc aaa ctc ata gcc ttt atg gtc     5404
 Tyr Ile Phe Trp Lys Arg Tyr Arg Phe Lys Leu Ile Ala Phe Met Val
             700                 705                 710

 ata tcg att ata gca ctt atg ctg ttt aac ttc atc tat tca gct ccg     5452
 Ile Ser Ile Ile Ala Leu Met Leu Phe Asn Phe Ile Tyr Ser Ala Pro
         715                 720                 725

 cac tat ttg gcc atg agc tgg atc aaa cct caa ctt cag ctg tat cct     5500
 His Tyr Leu Ala Met Ser Trp Ile Lys Pro Gln Leu Gln Leu Tyr Pro
     730                 735                 740

 ccc att aaa ata ttc aat atc atc aat tca cta aac acc agc aac gcc     5548
 Pro Ile Lys Ile Phe Asn Ile Ile Asn Ser Leu Asn Thr Ser Asn Ala
 745                 750                 755                 760

 agc tct tcc atc ctt ccc acc cag gat cca aac cta aag cct aca ata     5596
 Ser Ser Ser Ile Leu Pro Thr Gln Asp Pro Asn Leu Lys Pro Thr Ile
                 765                 770                 775

 gac cat gag tgg aaa ctc cac cca gga ccc aca aat cac ctg agt gat     5644
 Asp His Glu Trp Lys Leu His Pro Gly Pro Thr Asn His Leu Ser Asp
             780                 785                 790

 att ttc cca gaa ctt cca gcc cca gga gac taa                         5677
 Ile Phe Pro Glu Leu Pro Ala Pro Gly Asp 
         795                 800





      <210> 176
      <211> 4841
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (66)..(3689)

      <400> 176
 tgattttcca aaaaaaaaaa aaggtttttt aatggagaag taattcacat gccgtaaaat     60

 tctcc    atg tta aag ttt gca gct cgg tgc ttg aca ggc tat tca caa     107
          Met Leu Lys Phe Ala Ala Arg Cys Leu Thr Gly Tyr Ser Gln
            1               5                  10

 agc cgt gcg tca ctg ccc acc act ctc tca ttc aag gac act ttc atc      155
 Ser Arg Ala Ser Leu Pro Thr Thr Leu Ser Phe Lys Asp Thr Phe Ile
  15                  20                  25                  30

 ata aaa ggt ggc gtt gaa gac ctt gag ccg gac gcc tcc tgc tgg ccc      203
 Ile Lys Gly Gly Val Glu Asp Leu Glu Pro Asp Ala Ser Cys Trp Pro
                  35                  40                  45

 ctc cga gtg ctc tcc ctg ccc tgg ggg gct gtc ctg ggg ggg gag cga      251
 Leu Arg Val Leu Ser Leu Pro Trp Gly Ala Val Leu Gly Gly Glu Arg
              50                  55                  60

 ggg cac gcg gat aag tcc cta agg ttc ccc ggg tgg agg cac cag cag      299
 Gly His Ala Asp Lys Ser Leu Arg Phe Pro Gly Trp Arg His Gln Gln
          65                  70                  75

 gag agc ggg gga ggc aga ggg ccc acc atg cct gca act ccc aac ttc      347
 Glu Ser Gly Gly Gly Arg Gly Pro Thr Met Pro Ala Thr Pro Asn Phe
      80                  85                  90

 ctc gca aac ccc agc tcc agc agc cgc tgg att ccc ctc cag cca atg      395
 Leu Ala Asn Pro Ser Ser Ser Ser Arg Trp Ile Pro Leu Gln Pro Met
  95                 100                 105                 110

 ccc gtg gcc tgg gcc ttt gtg cag aag acc tcg gcc ctc ctg tgg ctg      443
 Pro Val Ala Trp Ala Phe Val Gln Lys Thr Ser Ala Leu Leu Trp Leu
                 115                 120                 125

 ctg ctt cta ggc acc tcc ctg tcc cct gcg tgg gga cag gcc aag att      491
 Leu Leu Leu Gly Thr Ser Leu Ser Pro Ala Trp Gly Gln Ala Lys Ile
             130                 135                 140

 cct ctg gaa aca gtg aag cta tgg gct gac acc ttc ggc ggg gac ctg      539
 Pro Leu Glu Thr Val Lys Leu Trp Ala Asp Thr Phe Gly Gly Asp Leu
         145                 150                 155

 tat aac act gtg acc aaa tac tca ggc tct ctc ttg ctg cag aag aag      587
 Tyr Asn Thr Val Thr Lys Tyr Ser Gly Ser Leu Leu Leu Gln Lys Lys
     160                 165                 170

 tac aag gat gtg gag tcc agt ctg aag atc gag gag gtg gat ggc ttg      635
 Tyr Lys Asp Val Glu Ser Ser Leu Lys Ile Glu Glu Val Asp Gly Leu
 175                 180                 185                 190

 gag ctg gtg agg aag ttc tca gag gac atg gag aac atg ctg cgg agg      683
 Glu Leu Val Arg Lys Phe Ser Glu Asp Met Glu Asn Met Leu Arg Arg
                 195                 200                 205

 aaa gtc gag gcg gtc cag aat ctg gtg gaa gct gcc gag gag gcc gac      731
 Lys Val Glu Ala Val Gln Asn Leu Val Glu Ala Ala Glu Glu Ala Asp
             210                 215                 220

 ctg aac cac gaa ttc aat gaa tcc ctg gtg ttc gac tat tac aac tcg      779
 Leu Asn His Glu Phe Asn Glu Ser Leu Val Phe Asp Tyr Tyr Asn Ser
         225                 230                 235

 gtc ctg atc aac gag agg gac gag aag ggc aac ttc gtg gag ctg ggc      827
 Val Leu Ile Asn Glu Arg Asp Glu Lys Gly Asn Phe Val Glu Leu Gly
     240                 245                 250

 gcc gag ttc ctc ctg gag tcc aat gct cac ttc agc aac ctg ccg gtg      875
 Ala Glu Phe Leu Leu Glu Ser Asn Ala His Phe Ser Asn Leu Pro Val
 255                 260                 265                 270

 aac acc tcc atc agc agc gtg cag ctg ccc acc aac gtg tac aac aaa      923
 Asn Thr Ser Ile Ser Ser Val Gln Leu Pro Thr Asn Val Tyr Asn Lys
                 275                 280                 285

 gac cca gat att tta aat gga gtc tac atg tct gaa gcc ttg aat gct      971
 Asp Pro Asp Ile Leu Asn Gly Val Tyr Met Ser Glu Ala Leu Asn Ala
             290                 295                 300

 gtc ttc gtg gag aac ttc cag aga gac cca acg ttg acc tgg caa tat     1019
 Val Phe Val Glu Asn Phe Gln Arg Asp Pro Thr Leu Thr Trp Gln Tyr
         305                 310                 315

 ttt ggc agt gca act gga ttc ttc agg atc tat cca ggt ata aaa tgg     1067
 Phe Gly Ser Ala Thr Gly Phe Phe Arg Ile Tyr Pro Gly Ile Lys Trp
     320                 325                 330

 aca cct gat gag aat gga gtc att act ttt gac tgc cga aac cgc ggc     1115
 Thr Pro Asp Glu Asn Gly Val Ile Thr Phe Asp Cys Arg Asn Arg Gly
 335                 340                 345                 350

 tgg tac att caa gct gct act tct ccc aag gac ata gtg att ttg gtg     1163
 Trp Tyr Ile Gln Ala Ala Thr Ser Pro Lys Asp Ile Val Ile Leu Val
                 355                 360                 365

 gac gtg agc ggc agt atg aag ggg ctg agg atg act att gcc aag cac     1211
 Asp Val Ser Gly Ser Met Lys Gly Leu Arg Met Thr Ile Ala Lys His
             370                 375                 380

 acc atc acc acc atc ttg gac acc ctg ggg gag aat gac ttc att aat     1259
 Thr Ile Thr Thr Ile Leu Asp Thr Leu Gly Glu Asn Asp Phe Ile Asn
         385                 390                 395

 atc ata gcg tac aat gac tac gtc cat tac atc gag cct tgt ttt aaa     1307
 Ile Ile Ala Tyr Asn Asp Tyr Val His Tyr Ile Glu Pro Cys Phe Lys
     400                 405                 410

 ggg atc ctc gtc cag gcg gac cga gac aat cga gag cat ttc aaa ctg     1355
 Gly Ile Leu Val Gln Ala Asp Arg Asp Asn Arg Glu His Phe Lys Leu
 415                 420                 425                 430

 ctg gtg gag gag ttg atg gtc aaa ggt gtg ggg gtc gtg gac caa gcc     1403
 Leu Val Glu Glu Leu Met Val Lys Gly Val Gly Val Val Asp Gln Ala
                 435                 440                 445

 ctg aga gaa gcc ttc cag atc ctg aag cag ttc caa gag gcc aag caa     1451
 Leu Arg Glu Ala Phe Gln Ile Leu Lys Gln Phe Gln Glu Ala Lys Gln
             450                 455                 460

 gga agc ctc tgc aac cag gcc atc atg ctc atc agc gac ggc gcc gtg     1499
 Gly Ser Leu Cys Asn Gln Ala Ile Met Leu Ile Ser Asp Gly Ala Val
         465                 470                 475

 gag gac tac gag ccg gtg ttt gag aag tat aac tgg cca gac tgt aag     1547
 Glu Asp Tyr Glu Pro Val Phe Glu Lys Tyr Asn Trp Pro Asp Cys Lys
     480                 485                 490

 gtc cga gtt ttc act tac ctc att ggg aga gaa gtg tct ttt gct gac     1595
 Val Arg Val Phe Thr Tyr Leu Ile Gly Arg Glu Val Ser Phe Ala Asp
 495                 500                 505                 510

 cgc atg aag tgg att gca tgc aac aac aaa ggc tac tac acg cag atc     1643
 Arg Met Lys Trp Ile Ala Cys Asn Asn Lys Gly Tyr Tyr Thr Gln Ile
                 515                 520                 525

 tca acg ctg gcg gac acc cag gag aac gtg atg gaa tac ctg cac gtg     1691
 Ser Thr Leu Ala Asp Thr Gln Glu Asn Val Met Glu Tyr Leu His Val
             530                 535                 540

 ctc agc cgc ccc atg gtc atc aac cac gac cac gac atc atc tgg aca     1739
 Leu Ser Arg Pro Met Val Ile Asn His Asp His Asp Ile Ile Trp Thr
         545                 550                 555

 gag gcc tac atg gac agc aag ctc ctc agc tcg cag gct cag agc ctg     1787
 Glu Ala Tyr Met Asp Ser Lys Leu Leu Ser Ser Gln Ala Gln Ser Leu
     560                 565                 570

 aca ctg ctc acc act gtg gcc atg cca gtc ttc agc aag aag aac gaa     1835
 Thr Leu Leu Thr Thr Val Ala Met Pro Val Phe Ser Lys Lys Asn Glu
 575                 580                 585                 590

 acg cga tcc cat ggc att ctc ctg ggt gtg gtg ggc tca gat gtg gcc     1883
 Thr Arg Ser His Gly Ile Leu Leu Gly Val Val Gly Ser Asp Val Ala
                 595                 600                 605

 ctg aga gag ctg atg aag ctg gcg ccc cgg tac aag ctt gga gtg cac     1931
 Leu Arg Glu Leu Met Lys Leu Ala Pro Arg Tyr Lys Leu Gly Val His
             610                 615                 620

 gga tac gcc ttt ctg aac acc aac aat ggc tac atc ctc tcc cat ccc     1979
 Gly Tyr Ala Phe Leu Asn Thr Asn Asn Gly Tyr Ile Leu Ser His Pro
         625                 630                 635

 gac ctc cgg ccc ctg tac aga gag ggg aag aaa cta aaa ccc aaa cct     2027
 Asp Leu Arg Pro Leu Tyr Arg Glu Gly Lys Lys Leu Lys Pro Lys Pro
     640                 645                 650

 aac tac aac agt gtg gat ctc tcc gaa gtg gag tgg gaa gac cag gct     2075
 Asn Tyr Asn Ser Val Asp Leu Ser Glu Val Glu Trp Glu Asp Gln Ala
 655                 660                 665                 670

 gaa tct ctg aga aca gcc atg atc aat agg gaa aca ggt act ctc tcg     2123
 Glu Ser Leu Arg Thr Ala Met Ile Asn Arg Glu Thr Gly Thr Leu Ser
                 675                 680                 685

 atg gat gtg aag gtt ccg atg gat aaa ggg aag cga gtt ctt ttc ctg     2171
 Met Asp Val Lys Val Pro Met Asp Lys Gly Lys Arg Val Leu Phe Leu
             690                 695                 700

 acc aat gac tac ttc ttc acg gac atc agc gac acc cct ttc agt ttg     2219
 Thr Asn Asp Tyr Phe Phe Thr Asp Ile Ser Asp Thr Pro Phe Ser Leu
         705                 710                 715

 ggg gtg gtg ctg tcc cgg ggc cac gga gaa tac atc ctt ctg ggg aac     2267
 Gly Val Val Leu Ser Arg Gly His Gly Glu Tyr Ile Leu Leu Gly Asn
     720                 725                 730

 acg tct gtg gaa gaa ggc ctg cat gac ttg ctt cac cca gac ctg gcc     2315
 Thr Ser Val Glu Glu Gly Leu His Asp Leu Leu His Pro Asp Leu Ala
 735                 740                 745                 750

 ctg gcc ggt gac tgg atc tac tgc atc aca gat att gac cca gac cac     2363
 Leu Ala Gly Asp Trp Ile Tyr Cys Ile Thr Asp Ile Asp Pro Asp His
                 755                 760                 765

 cgg aag ctc agc cag cta gag gcc atg atc cgc ttc ctc acc agg aag     2411
 Arg Lys Leu Ser Gln Leu Glu Ala Met Ile Arg Phe Leu Thr Arg Lys
             770                 775                 780

 gac cca gac ctg gag tgt gac gag gag ctg gtc cgg gag gtg ctg ttt     2459
 Asp Pro Asp Leu Glu Cys Asp Glu Glu Leu Val Arg Glu Val Leu Phe
         785                 790                 795

 gac gcg gtg gtg aca gcc ccc atg gaa gcc tac tgg aca gcg ctg gcc     2507
 Asp Ala Val Val Thr Ala Pro Met Glu Ala Tyr Trp Thr Ala Leu Ala
     800                 805                 810

 ctc aac atg tcc gag gag tct gaa cac gtg gtg gac atg gcc ttc ctg     2555
 Leu Asn Met Ser Glu Glu Ser Glu His Val Val Asp Met Ala Phe Leu
 815                 820                 825                 830

 ggc acc cgg gct ggc ctc ctg aga agc agc ttg ttc gtg ggc tcc gag     2603
 Gly Thr Arg Ala Gly Leu Leu Arg Ser Ser Leu Phe Val Gly Ser Glu
                 835                 840                 845

 aag gtc tcc gac agg aag ttc ctg aca cct gag gac gag gcc agc gtg     2651
 Lys Val Ser Asp Arg Lys Phe Leu Thr Pro Glu Asp Glu Ala Ser Val
             850                 855                 860

 ttc acc ctg gac cgc ttc ccg ctg tgg tac cgc cag gcc tca gag cat     2699
 Phe Thr Leu Asp Arg Phe Pro Leu Trp Tyr Arg Gln Ala Ser Glu His
         865                 870                 875

 cct gct ggc agc ttc gtc ttc aac ctc cgc tgg gca gaa gga cca gaa     2747
 Pro Ala Gly Ser Phe Val Phe Asn Leu Arg Trp Ala Glu Gly Pro Glu
     880                 885                 890

 agt gcg ggt gaa ccc atg gtg gtg acg gca agc aca gct gtg gcg gtg     2795
 Ser Ala Gly Glu Pro Met Val Val Thr Ala Ser Thr Ala Val Ala Val
 895                 900                 905                 910

 acc gtg gac aag agg aca gcc att gct gca gcc gcg ggc gtc caa atg     2843
 Thr Val Asp Lys Arg Thr Ala Ile Ala Ala Ala Ala Gly Val Gln Met
                 915                 920                 925

 aag ctg gaa ttc ctc cag cgc aaa ttc tgg gcg gca acg cgg cag tgc     2891
 Lys Leu Glu Phe Leu Gln Arg Lys Phe Trp Ala Ala Thr Arg Gln Cys
             930                 935                 940

 agc act gtg gat ggg ccg tgc aca cag agc tgc gag gac agt gat ctg     2939
 Ser Thr Val Asp Gly Pro Cys Thr Gln Ser Cys Glu Asp Ser Asp Leu
         945                 950                 955

 gac tgc ttc gtc atc gac aac aac ggg ttc att ctg atc tcc aag agg     2987
 Asp Cys Phe Val Ile Asp Asn Asn Gly Phe Ile Leu Ile Ser Lys Arg
     960                 965                 970

 tcc cga gag acg gga aga ttt ctg ggg gag gtg gat ggt gct gtc ctg     3035
 Ser Arg Glu Thr Gly Arg Phe Leu Gly Glu Val Asp Gly Ala Val Leu
 975                 980                 985                 990

 acc cag ctg ctc agc atg ggg gtg ttc agc caa gtg act atg tat gac     3083
 Thr Gln Leu Leu Ser Met Gly Val Phe Ser Gln Val Thr Met Tyr Asp
                 995                1000                1005

 tat cag gcc atg tgc aaa ccc tcg agt cac cac cac agt gca gcc cag     3131
 Tyr Gln Ala Met Cys Lys Pro Ser Ser His His His Ser Ala Ala Gln
            1010                1015                1020

 ccc ctg gtc agc cca att tct gcc ttc ttg acg gcg acc agg tgg ctg     3179
 Pro Leu Val Ser Pro Ile Ser Ala Phe Leu Thr Ala Thr Arg Trp Leu
        1025                1030                1035

 ctg cag gag ctg gtg ctg ttc ctg ctg gag tgg agt gtc tgg ggc tcc     3227
 Leu Gln Glu Leu Val Leu Phe Leu Leu Glu Trp Ser Val Trp Gly Ser
    1040                1045                1050

 tgg tac gac aga ggg gcc gag gcc aaa agt gtc ttc cat cac tcc cac     3275
 Trp Tyr Asp Arg Gly Ala Glu Ala Lys Ser Val Phe His His Ser His
1055                1060                1065                1070

 aaa cac aag aag cag gac ccg ctg cag ccc tgc gac acg gag tac ccc     3323
 Lys His Lys Lys Gln Asp Pro Leu Gln Pro Cys Asp Thr Glu Tyr Pro
                1075                1080                1085

 gtg ttc gtg tac cag ccg gcc atc cgg gag gcc aac ggg atc gtg gag     3371
 Val Phe Val Tyr Gln Pro Ala Ile Arg Glu Ala Asn Gly Ile Val Glu
            1090                1095                1100

 tgc ggg ccc tgc cag aag gta ttt gtg gtg cag cag att ccc aac agt     3419
 Cys Gly Pro Cys Gln Lys Val Phe Val Val Gln Gln Ile Pro Asn Ser
        1105                1110                1115

 aac ctc ctc ctc ctg gtg aca gac ccc acc tgt gac tgc agc atc ttc     3467
 Asn Leu Leu Leu Leu Val Thr Asp Pro Thr Cys Asp Cys Ser Ile Phe
    1120                1125                1130

 cca cca gtg ctg cag gag gcg aca gaa gtc aaa tat aat gcc tct gtc     3515
 Pro Pro Val Leu Gln Glu Ala Thr Glu Val Lys Tyr Asn Ala Ser Val
1135                1140                1145                1150

 aaa tgt gac cgg atg cgc tcc cag aag ctc cgc cgg cga cca gac tcc     3563
 Lys Cys Asp Arg Met Arg Ser Gln Lys Leu Arg Arg Arg Pro Asp Ser
                1155                1160                1165

 tgc cac gcc ttc cat cca gag gag aat gcc cag gac tgc ggc ggc gcc     3611
 Cys His Ala Phe His Pro Glu Glu Asn Ala Gln Asp Cys Gly Gly Ala
            1170                1175                1180

 tcg gac acc tca gcc tcg ccg ccc cta ctc ctg ctg cct gtg tgt gcc     3659
 Ser Asp Thr Ser Ala Ser Pro Pro Leu Leu Leu Leu Pro Val Cys Ala
        1185                1190                1195

 tgg ggg cta ctg ccc caa ctc ctg cgg tga c accacccagc ctgacctgtg     3710
 Trp Gly Leu Leu Pro Gln Leu Leu Arg 
    1200                1205

 ttttggcaag gtgatccttc cagagccatc ccaaaaagtc agcactgaca tgggatgcag   3770

 ctaactgcag ttgggtcgcc cccaggccaa cgctcctctc aatcctgggc tggtggcccc   3830

 tggctccgga gaatgctgga tggaacagga aaccaatcac ctggcaccac tttcaagatg   3890

 cttcatggtg cccggtacca tctgccctag gtctcaacat gagcatactt ctgacctaac   3950

 cttcctgtct cctcttcggg aagccagcgt gagctcagct tggaccaaga caaaataatt   4010

 tagttcttcc tgtactccag agtccagacc cagccaagaa agggtcagtt gtttctgacc   4070

 ctttctgtcg gagtggtctc tggtagaacc caaggacttc tgggtactga gaagcagcag   4130

 cagaatgagg ccaaatgcag agatgaggct aaggcaagaa tatgccccaa ctaaagcata   4190

 gattccccaa agtgagtctc atggtgggag gccactcacc ttcctagctg ctgctcgaaa   4250

 aggttttgac tgtgttgggg tgggggttgg gtaagggaat ggtcaagact gagaaaggaa   4310

 tgaaatccat tcaggaaata tcgacagggc tacacgtgat gtccccaaac tgctgctatt   4370

 gaagaacttc ccaaaacttc tttacaaagc cctaaaggaa agtttgcatc tatgaaaagc   4430

 caataggctg agacatccaa ttgctgcatg gaaattgatg tacattcagg ggacggcaaa   4490

 aatagctgta aaatagtgaa aaagagcagt ggttgtgctc ttttctggcc aatgatttac   4550

 aaaagaatct acttgactct gtccctggag tgaaatcctt agggttggaa cttgtgggaa   4610

 cattccaact tgctaagcag ggtccactgg gagggaagct ctatctggga actcaccccc   4670

 agcgcacaca catctccccc agggtcccaa ggccccgcag cttcctcccc cgaccaaacc   4730

 ccaagacctg gatcccagga gacaacagtc tccacagtga gagcaacatt aagggcaaag   4790

 ccatggagaa atgtgggaga ggccggcctc aaatctttcc atttaacaaa c            4841




      <210> 177
      <211> 2028
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (1)..(2028)

      <400> 177
  atg ggc att tat ggt tca gta cct tat ctc ctg gcc cac aaa ctg ggc      48
  Met Gly Ile Tyr Gly Ser Val Pro Tyr Leu Leu Ala His Lys Leu Gly
    1               5                  10                  15

 aga act ata ggt att ttc tgg ctg aat gcc tcg gaa aca ctg gtg gag       96
 Arg Thr Ile Gly Ile Phe Trp Leu Asn Ala Ser Glu Thr Leu Val Glu
              20                  25                  30

 atc aat aca gag cct gca gta gag tac aca ctg acc cag atg ggc cca      144
 Ile Asn Thr Glu Pro Ala Val Glu Tyr Thr Leu Thr Gln Met Gly Pro
          35                  40                  45

 gtt gct gct aaa caa aag gtc aga tct cgc act cat gtg cac tgg atg      192
 Val Ala Ala Lys Gln Lys Val Arg Ser Arg Thr His Val His Trp Met
      50                  55                  60

 tca gag agt ggc atc att gat gtt ttt ctg ctg aca gga cct aca cct      240
 Ser Glu Ser Gly Ile Ile Asp Val Phe Leu Leu Thr Gly Pro Thr Pro
  65                  70                  75                  80

 tct gat gtc ttc aaa cag tac tca cac ctt aca ggt att tgc acg aag      288
 Ser Asp Val Phe Lys Gln Tyr Ser His Leu Thr Gly Ile Cys Thr Lys
                  85                  90                  95

 aag tgc cag ttt ctt gtt ctg tta cat atc caa tgt ccc atg tgt cat      336
 Lys Cys Gln Phe Leu Val Leu Leu His Ile Gln Cys Pro Met Cys His
             100                 105                 110

 cac ggc aca caa gcc atg ccc cct ctt ttc tct ttg gga tac cac cag      384
 His Gly Thr Gln Ala Met Pro Pro Leu Phe Ser Leu Gly Tyr His Gln
         115                 120                 125

 tgc cgc tgg aac tat gaa gat gag cag gat gta aaa gca gtg gat gca      432
 Cys Arg Trp Asn Tyr Glu Asp Glu Gln Asp Val Lys Ala Val Asp Ala
     130                 135                 140

 ggg ttt gat gag cat gac att cct tat gat gcc atg tgg ctg gac ata      480
 Gly Phe Asp Glu His Asp Ile Pro Tyr Asp Ala Met Trp Leu Asp Ile
 145                 150                 155                 160

 gag cac act gag ggc aag agg tac ttc acc tgg gac aaa aac aga ttc      528
 Glu His Thr Glu Gly Lys Arg Tyr Phe Thr Trp Asp Lys Asn Arg Phe
                 165                 170                 175

 cca aac ccc aag agg atg caa gag ctg ctc agg agc aaa aag cgt aag      576
 Pro Asn Pro Lys Arg Met Gln Glu Leu Leu Arg Ser Lys Lys Arg Lys
             180                 185                 190

 ctt gtg gtc atc agt gat ccc cac atc aag att gat cct gac tac tca      624
 Leu Val Val Ile Ser Asp Pro His Ile Lys Ile Asp Pro Asp Tyr Ser
         195                 200                 205

 gta tat gtg aag gcc aaa gat cag ggc ttc ttt gtg aag aat cag gaa      672
 Val Tyr Val Lys Ala Lys Asp Gln Gly Phe Phe Val Lys Asn Gln Glu
     210                 215                 220

 ggg gaa gac ttt gaa ggg gtg tgt tgg cca ggt ctc tcc tct tac ctg      720
 Gly Glu Asp Phe Glu Gly Val Cys Trp Pro Gly Leu Ser Ser Tyr Leu
 225                 230                 235                 240

 gat ttc acc aat ccc aag gtc aga gag tgg tat tca agt ctt ttt gct      768
 Asp Phe Thr Asn Pro Lys Val Arg Glu Trp Tyr Ser Ser Leu Phe Ala
                 245                 250                 255

 ttc cct gtt tat cag gga tct acg gac atc ctc ttc ctt tgg aat gac      816
 Phe Pro Val Tyr Gln Gly Ser Thr Asp Ile Leu Phe Leu Trp Asn Asp
             260                 265                 270

 atg aat gag cct tct gtc ttt aga ggg cca gag caa acc atg cag aag      864
 Met Asn Glu Pro Ser Val Phe Arg Gly Pro Glu Gln Thr Met Gln Lys
         275                 280                 285

 aat gcc att cat cat ggc aat tgg gag cac aga gag ctc cac aac atc      912
 Asn Ala Ile His His Gly Asn Trp Glu His Arg Glu Leu His Asn Ile
     290                 295                 300

 tac ggt ttt tat cat caa atg gct act gca gaa gga ctg ata aaa cga      960
 Tyr Gly Phe Tyr His Gln Met Ala Thr Ala Glu Gly Leu Ile Lys Arg
 305                 310                 315                 320

 tct aaa ggg aag gag aga ccc ttt gtt ctt aca cgt tct ttc ttt gct     1008
 Ser Lys Gly Lys Glu Arg Pro Phe Val Leu Thr Arg Ser Phe Phe Ala
                 325                 330                 335

 gga tca caa aag tat ggt gcc gtg tgg aca ggc gac aac aca gca gaa     1056
 Gly Ser Gln Lys Tyr Gly Ala Val Trp Thr Gly Asp Asn Thr Ala Glu
             340                 345                 350

 tgg agc aac ttg aaa att tct atc cca atg tta ctc act ctc agc att     1104
 Trp Ser Asn Leu Lys Ile Ser Ile Pro Met Leu Leu Thr Leu Ser Ile
         355                 360                 365

 act ggg atc tct ttt tgc gga gct gac ata ggc ggg ttc att ggg aat     1152
 Thr Gly Ile Ser Phe Cys Gly Ala Asp Ile Gly Gly Phe Ile Gly Asn
     370                 375                 380

 cca gag aca gag ctg cta gtg cgt tgg tac cag gct gga gcc tac cag     1200
 Pro Glu Thr Glu Leu Leu Val Arg Trp Tyr Gln Ala Gly Ala Tyr Gln
 385                 390                 395                 400

 ccc ttc ttc cgt ggc cat gcc acc atg aac acc aag cga cga gag ccc     1248
 Pro Phe Phe Arg Gly His Ala Thr Met Asn Thr Lys Arg Arg Glu Pro
                 405                 410                 415

 tgg ctc ttt ggg gag gaa cac acc cga ctc atc cga gaa gcc atc aga     1296
 Trp Leu Phe Gly Glu Glu His Thr Arg Leu Ile Arg Glu Ala Ile Arg
             420                 425                 430

 gag cgc tat ggc ctc ctg cca tat tgg tat tct ctg ttc tac cat gca     1344
 Glu Arg Tyr Gly Leu Leu Pro Tyr Trp Tyr Ser Leu Phe Tyr His Ala
         435                 440                 445

 cac gtg gct tcc caa cct gtc atg agg cct ctg tgg gta gag ttc cct     1392
 His Val Ala Ser Gln Pro Val Met Arg Pro Leu Trp Val Glu Phe Pro
     450                 455                 460

 gat gaa cta aag act ttt gat atg gaa gat gaa tac atg ctg ggg agt     1440
 Asp Glu Leu Lys Thr Phe Asp Met Glu Asp Glu Tyr Met Leu Gly Ser
 465                 470                 475                 480

 gca tta ttg gtt cat cca gtc aca gaa cca aaa gcc acc aca gtt gat     1488
 Ala Leu Leu Val His Pro Val Thr Glu Pro Lys Ala Thr Thr Val Asp
                 485                 490                 495

 gtg ttt ctt cca gga tca aat gag gtc tgg tat gac tat aag aca ttt     1536
 Val Phe Leu Pro Gly Ser Asn Glu Val Trp Tyr Asp Tyr Lys Thr Phe
             500                 505                 510

 gct cat tgg gaa gga ggg tgt act gta aag atc cca gta gcc ttg gac     1584
 Ala His Trp Glu Gly Gly Cys Thr Val Lys Ile Pro Val Ala Leu Asp
         515                 520                 525

 act att cca gtg ttt cag cga ggt gga agt gtg ata cca ata aag aca     1632
 Thr Ile Pro Val Phe Gln Arg Gly Gly Ser Val Ile Pro Ile Lys Thr
     530                 535                 540

 act gta gga aaa tcc aca ggc tgg atg act gaa tcc tcc tat gga ctc     1680
 Thr Val Gly Lys Ser Thr Gly Trp Met Thr Glu Ser Ser Tyr Gly Leu
 545                 550                 555                 560

 cgg gtt gct cta agc act aag ggt tct tca gtg ggt gag tta tat ctt     1728
 Arg Val Ala Leu Ser Thr Lys Gly Ser Ser Val Gly Glu Leu Tyr Leu
                 565                 570                 575

 gat gat ggc cat tca ttc caa tac ctc cac cag aag caa ttt ttg cac     1776
 Asp Asp Gly His Ser Phe Gln Tyr Leu His Gln Lys Gln Phe Leu His
             580                 585                 590

 agg aag ttt tca ttc tgt tcc agt gtt ctg atc aat agt tct gct gac     1824
 Arg Lys Phe Ser Phe Cys Ser Ser Val Leu Ile Asn Ser Ser Ala Asp
         595                 600                 605

 cag agg ggt cat tat ccc agc aag tgt gtg gtg gag aag atc ttg gtc     1872
 Gln Arg Gly His Tyr Pro Ser Lys Cys Val Val Glu Lys Ile Leu Val
     610                 615                 620

 tta ggc ttc agg aag gag cca tct tct gtg act acc cac tca tct gat     1920
 Leu Gly Phe Arg Lys Glu Pro Ser Ser Val Thr Thr His Ser Ser Asp
 625                 630                 635                 640

 ggt aaa gat cag cct gtg gct ttt acg tat tgt gcc aaa aca tcc atc     1968
 Gly Lys Asp Gln Pro Val Ala Phe Thr Tyr Cys Ala Lys Thr Ser Ile
                 645                 650                 655

 ctg agc ctg gag aag ctc tca ctc aac att gcc act gac tgg gag gtc     2016
 Leu Ser Leu Glu Lys Leu Ser Leu Asn Ile Ala Thr Asp Trp Glu Val
             660                 665                 670

 cgc atc ata tga                                                     2028
 Arg Ile Ile 
         675





      <210> 178
      <211> 252
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (1)..(252)

      <400> 178
  atg gac gcc gtt aaa cat cct aca gtg caa gcg cag ccc ccg acc acg      48
  Met Asp Ala Val Lys His Pro Thr Val Gln Ala Gln Pro Pro Thr Thr
    1               5                  10                  15

 aag agt tgt ctt gct caa ata tca aca gtg ctg cag tgt aga aac ttg       96
 Lys Ser Cys Leu Ala Gln Ile Ser Thr Val Leu Gln Cys Arg Asn Leu
              20                  25                  30

 atc gtt ggt ttt ctt tta atg caa aac tct cat aaa aac ctt tca ctt      144
 Ile Val Gly Phe Leu Leu Met Gln Asn Ser His Lys Asn Leu Ser Leu
          35                  40                  45

 ttc ctg tca ttg att ata tgc ttg ata cac cca aaa aga aaa ggg gag      192
 Phe Leu Ser Leu Ile Ile Cys Leu Ile His Pro Lys Arg Lys Gly Glu
      50                  55                  60

 ggg cac caa ttc acc tac act cca gtg gct cca tca cct tta aaa ata      240
 Gly His Gln Phe Thr Tyr Thr Pro Val Ala Pro Ser Pro Leu Lys Ile
  65                  70                  75                  80

 ttt ata aaa tag                                                      252
 Phe Ile Lys 






      <210> 179
      <211> 3585
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (51)..(2582)

      <400> 179
 gagcggtgcg agggaaaccc tgcactctga gctggattgg gtcgcgtgcg   atg tgc      56
                                                          Met Cys
                                                            1

 ggg ctc ctg gca gac cct ggg gtt ccg ctg ctc gtt gcc atg gct ccc      104
 Gly Leu Leu Ala Asp Pro Gly Val Pro Leu Leu Val Ala Met Ala Pro
           5                  10                  15

 gcc gga gcg gcc aga gcg ggc gtc ggg ttg ggt gtc agc ggt att ccg      152
 Ala Gly Ala Ala Arg Ala Gly Val Gly Leu Gly Val Ser Gly Ile Pro
      20                  25                  30

 ggc ccg gtt ctc cac cca ggc ctg gac ctg gac cct cgg gca ctg cag      200
 Gly Pro Val Leu His Pro Gly Leu Asp Leu Asp Pro Arg Ala Leu Gln
  35                  40                  45                  50

 cgt ccg tct gta ggt ttc cag gca gag gaa atc ctg aga cat cca ggc      248
 Arg Pro Ser Val Gly Phe Gln Ala Glu Glu Ile Leu Arg His Pro Gly
                  55                  60                  65

 gca gct ggg agt tgc tac ctg gct cca tcc gtg agc aca gcg agg tgc      296
 Ala Ala Gly Ser Cys Tyr Leu Ala Pro Ser Val Ser Thr Ala Arg Cys
              70                  75                  80

 tgt ctt tca tgc tta tct gtc ttc ctc ttg aat tca gat tcc caa cct      344
 Cys Leu Ser Cys Leu Ser Val Phe Leu Leu Asn Ser Asp Ser Gln Pro
          85                  90                  95

 gct gag cat ccg cac acc cac tca gga gtt ggg gcc cag ctc cca gtt      392
 Ala Glu His Pro His Thr His Ser Gly Val Gly Ala Gln Leu Pro Val
     100                 105                 110

 tac ttg gtt tcc ctt gtg cag cct ggg gct ctg ccc agg cca cca cag      440
 Tyr Leu Val Ser Leu Val Gln Pro Gly Ala Leu Pro Arg Pro Pro Gln
 115                 120                 125                 130

 gca ggg gtc gac atg gca gag aca ctg gag ttc aac gac gtc tat cag      488
 Ala Gly Val Asp Met Ala Glu Thr Leu Glu Phe Asn Asp Val Tyr Gln
                 135                 140                 145

 gag gtg aaa ggt tcc atg aat gat ggt cga ctg agg ttg agc cgt cag      536
 Glu Val Lys Gly Ser Met Asn Asp Gly Arg Leu Arg Leu Ser Arg Gln
             150                 155                 160

 ggc atc atc ttc aag aat agc aag aca ggc aaa gtg gac aac atc cag      584
 Gly Ile Ile Phe Lys Asn Ser Lys Thr Gly Lys Val Asp Asn Ile Gln
         165                 170                 175

 gct ggg gag tta aca gaa ggt atc tgg cgc cgt gtt gct ctg ggc cat      632
 Ala Gly Glu Leu Thr Glu Gly Ile Trp Arg Arg Val Ala Leu Gly His
     180                 185                 190

 gga ctt aaa ctg ctt aca aag aat ggc cat gtc tac aag tat gat ggc      680
 Gly Leu Lys Leu Leu Thr Lys Asn Gly His Val Tyr Lys Tyr Asp Gly
 195                 200                 205                 210

 ttc cga gaa tcg gag ttt gag aaa ctc tct gat ttc ttc aaa act cac      728
 Phe Arg Glu Ser Glu Phe Glu Lys Leu Ser Asp Phe Phe Lys Thr His
                 215                 220                 225

 tat cgc ctt gag cta atg gag aag gac ctt tgt gtg aag ggc tgg aac      776
 Tyr Arg Leu Glu Leu Met Glu Lys Asp Leu Cys Val Lys Gly Trp Asn
             230                 235                 240

 tgg ggg aca gtg aaa ttt ggt ggg cag ctg ctt tcc ttt gac att ggt      824
 Trp Gly Thr Val Lys Phe Gly Gly Gln Leu Leu Ser Phe Asp Ile Gly
         245                 250                 255

 gac cag cca gtc ttt gag ata ccc ctc agc aat gtg tcc cag tgc acc      872
 Asp Gln Pro Val Phe Glu Ile Pro Leu Ser Asn Val Ser Gln Cys Thr
     260                 265                 270

 aca ggc aag aat gag gtg aca ctg gaa ttc cac caa aac gat gac gca      920
 Thr Gly Lys Asn Glu Val Thr Leu Glu Phe His Gln Asn Asp Asp Ala
 275                 280                 285                 290

 gag gtg tct ctc atg gag gtg cgc ttc tac gtc cca ccc acc cag gag      968
 Glu Val Ser Leu Met Glu Val Arg Phe Tyr Val Pro Pro Thr Gln Glu
                 295                 300                 305

 gat ggt gtg gac cct gtt gag gcc ttt gcc cag aat gtg ttg tca aag     1016
 Asp Gly Val Asp Pro Val Glu Ala Phe Ala Gln Asn Val Leu Ser Lys
             310                 315                 320

 gcg gat gta atc cag gcc acg gga gat gcc atc tgc atc ttc cgg gag     1064
 Ala Asp Val Ile Gln Ala Thr Gly Asp Ala Ile Cys Ile Phe Arg Glu
         325                 330                 335

 ctg cag tgt ctg act cct cgt ggt cgt tat gac att cgg atc tac ccc     1112
 Leu Gln Cys Leu Thr Pro Arg Gly Arg Tyr Asp Ile Arg Ile Tyr Pro
     340                 345                 350

 acc ttt ctg cac ctg cat ggc aag acc ttt gac tac aag atc ccc tac     1160
 Thr Phe Leu His Leu His Gly Lys Thr Phe Asp Tyr Lys Ile Pro Tyr
 355                 360                 365                 370

 acc aca gta ctg cgt ctg ttt ttg tta ccc cac aag gac cag cgc cag     1208
 Thr Thr Val Leu Arg Leu Phe Leu Leu Pro His Lys Asp Gln Arg Gln
                 375                 380                 385

 atg ttc ttt gtg atc agc ctg gat ccc cca atc aag caa ggc caa act     1256
 Met Phe Phe Val Ile Ser Leu Asp Pro Pro Ile Lys Gln Gly Gln Thr
             390                 395                 400

 cgc tac cac ttc ctg atc ctc ctc ttc tcc aag gac gag gac att tcg     1304
 Arg Tyr His Phe Leu Ile Leu Leu Phe Ser Lys Asp Glu Asp Ile Ser
         405                 410                 415

 ttg act ctg aac atg aac gag gaa gaa gtg gag aag cgc ttt gag ggt     1352
 Leu Thr Leu Asn Met Asn Glu Glu Glu Val Glu Lys Arg Phe Glu Gly
     420                 425                 430

 cgg ctc acc aag aac atg tca gga tcc ctc tat gag atg gtc agc cgg     1400
 Arg Leu Thr Lys Asn Met Ser Gly Ser Leu Tyr Glu Met Val Ser Arg
 435                 440                 445                 450

 gtc atg aaa gca ctg gta aac cgc aag atc aca gtg cca ggc aac ttc     1448
 Val Met Lys Ala Leu Val Asn Arg Lys Ile Thr Val Pro Gly Asn Phe
                 455                 460                 465

 caa ggg cac tca ggg gcc cag tgc att acc tgt tcc tac aag gca agc     1496
 Gln Gly His Ser Gly Ala Gln Cys Ile Thr Cys Ser Tyr Lys Ala Ser
             470                 475                 480

 tca gga ctg ctc tac ccg ctg gag cgg ggc ttc atc tac gtc cac aag     1544
 Ser Gly Leu Leu Tyr Pro Leu Glu Arg Gly Phe Ile Tyr Val His Lys
         485                 490                 495

 cca cct gtg cac atc cgc ttc gat gag atc tcc ttt gtc aac ttt gct     1592
 Pro Pro Val His Ile Arg Phe Asp Glu Ile Ser Phe Val Asn Phe Ala
     500                 505                 510

 cgt ggt acc act act act cgt tcc ttt gac ttt gaa att gag acc aag     1640
 Arg Gly Thr Thr Thr Thr Arg Ser Phe Asp Phe Glu Ile Glu Thr Lys
 515                 520                 525                 530

 cag ggc act cag tat acc ttc agc agc att gag agg gag gag tac ggg     1688
 Gln Gly Thr Gln Tyr Thr Phe Ser Ser Ile Glu Arg Glu Glu Tyr Gly
                 535                 540                 545

 aaa ctg ttt gat ttt gtc aac gcg aaa aag ctc aac atc aaa aac cga     1736
 Lys Leu Phe Asp Phe Val Asn Ala Lys Lys Leu Asn Ile Lys Asn Arg
             550                 555                 560

 gga ttg aaa gag ggc atg aac cca agc tac gat gaa tat gct gac tct     1784
 Gly Leu Lys Glu Gly Met Asn Pro Ser Tyr Asp Glu Tyr Ala Asp Ser
         565                 570                 575

 gat gag gac cag cat gat gcc tac ttg gag agg atg aag gag gaa ggc     1832
 Asp Glu Asp Gln His Asp Ala Tyr Leu Glu Arg Met Lys Glu Glu Gly
     580                 585                 590

 aag atc cgg gag gag aat gcc aat gac agc agc gat gac tca gga gaa     1880
 Lys Ile Arg Glu Glu Asn Ala Asn Asp Ser Ser Asp Asp Ser Gly Glu
 595                 600                 605                 610

 gaa acc gat gag tca ttc aac cca ggt gaa gag gag gaa gat gtg gca     1928
 Glu Thr Asp Glu Ser Phe Asn Pro Gly Glu Glu Glu Glu Asp Val Ala
                 615                 620                 625

 gag gag ttt gac agc aac gcc tct gcc agc tcc tcc agt aat gag ggt     1976
 Glu Glu Phe Asp Ser Asn Ala Ser Ala Ser Ser Ser Ser Asn Glu Gly
             630                 635                 640

 gac agt gac cgg gat gag aag aag cgg aaa cag ctc aaa aag gcc aag     2024
 Asp Ser Asp Arg Asp Glu Lys Lys Arg Lys Gln Leu Lys Lys Ala Lys
         645                 650                 655

 atg gcc aag gac cgc aag agc cgc aag aag cct gtg gag gtg aag aag     2072
 Met Ala Lys Asp Arg Lys Ser Arg Lys Lys Pro Val Glu Val Lys Lys
     660                 665                 670

 ggc aaa gac ccc aat gcc ccc aag agg ccc atg tct gca tac atg ctg     2120
 Gly Lys Asp Pro Asn Ala Pro Lys Arg Pro Met Ser Ala Tyr Met Leu
 675                 680                 685                 690

 tgg ctc aat gcc agc cga gag aag atc aag tca gac cat cct ggc atc     2168
 Trp Leu Asn Ala Ser Arg Glu Lys Ile Lys Ser Asp His Pro Gly Ile
                 695                 700                 705

 agc atc acg gat ctt tcc aag aag gca ggc gag atc tgg aag gga atg     2216
 Ser Ile Thr Asp Leu Ser Lys Lys Ala Gly Glu Ile Trp Lys Gly Met
             710                 715                 720

 tcc aaa gag aag aaa gag gag tgg gat cgc aag gct gag gat gcc agg     2264
 Ser Lys Glu Lys Lys Glu Glu Trp Asp Arg Lys Ala Glu Asp Ala Arg
         725                 730                 735

 agg gac tat gaa aaa gcc atg aaa gaa tat gaa ggg ggc cga ggc gag     2312
 Arg Asp Tyr Glu Lys Ala Met Lys Glu Tyr Glu Gly Gly Arg Gly Glu
     740                 745                 750

 tct tct aag agg gac aag tca aag aag aag aag aaa gta aag gta aag     2360
 Ser Ser Lys Arg Asp Lys Ser Lys Lys Lys Lys Lys Val Lys Val Lys
 755                 760                 765                 770

 atg gaa aag aaa tcc acg ccc tct agg ggc tca tca tcc aag tcg tcc     2408
 Met Glu Lys Lys Ser Thr Pro Ser Arg Gly Ser Ser Ser Lys Ser Ser
                 775                 780                 785

 tca agg cag cta agc gag agc ttc aag agc aaa gag ttt gtg tct agt     2456
 Ser Arg Gln Leu Ser Glu Ser Phe Lys Ser Lys Glu Phe Val Ser Ser
             790                 795                 800

 gat gag agc tct tcg gga gag aac aag agc aaa aag aag agg agg agg     2504
 Asp Glu Ser Ser Ser Gly Glu Asn Lys Ser Lys Lys Lys Arg Arg Arg
         805                 810                 815

 agc gag gac tct gaa gaa gaa gaa cta gcc agt act ccc ccc agc tca     2552
 Ser Glu Asp Ser Glu Glu Glu Glu Leu Ala Ser Thr Pro Pro Ser Ser
     820                 825                 830

 gag gac tca gcg tca gga tcc gat gag tag a aacggaggaa ggttctcttt     2603
 Glu Asp Ser Ala Ser Gly Ser Asp Glu 
 835                 840

 gcgcttgcct tctcacaccc cccgactccc cacccatatt ttggtaccag tttctcctca   2663

 tgaaatgcag tccctggatt ctgtgccatc tgaacatgct ctcctgttgg tgtgtatgtc   2723

 actagggcag tggggagacg tcttaactct gctgcttccc aaggatggct gtttataatt   2783

 tggggagaga tagggtggga ggcagggcaa tgcaggatcc aaatcctcat cttactttcc   2843

 cgaccttaag gatgtagctg ctgcttgtcc tgttcaagtt gctggagcag gggtcatgtg   2903

 aggccaggcc tgtagctcct acctggggcc tatttctact ttcattttgt atttctggtc   2963

 tgtgaaaatg atttaataaa ggggaacgtg atctttgtgc aaaatgataa atgaaagtag   3023

 gatgcatgaa ttgagcaatt tttggggcgg ggttgatgtt tcccctgaaa atagcgtgta   3083

 tcaaagtgac ctggcagacg atagaggagg tgacgaggag cccccacgac aggttggaag   3143

 gagacgacca gtgccgcaga gagggcagtg tcccgctggt ggtgaagacc tccggggact   3203

 cgggcacctg agggtgcttg gtgtatgttt gcctcgccag aaatatataa agacccaggt   3263

 ggggggggtg aagcaaacac gcgctgtggg cttgaggaaa gcaaaaacca cgcaattgga   3323

 gaggacacgt tcccgaaggg gagagaactt cgattcgcgg gggacccgcc acgcaaataa   3383

 ctggggattg gcgccagaat gggtccaccg ttaaaaatcc taattgataa ggcgtcccgg   3443

 gggccgtgat tgtggtggat ttgagcccgg cacaaggttg gaaaggacct tttggttacc   3503

 agcaattgct gtttcaaact tttctttgta ccaaaaattt gtttactttg gccttttttc   3563

 cttttgtttg taacttatct tg                                            3585




      <210> 180
      <211> 2061
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (1)..(2061)

      <400> 180
  atg gcc ata ggc ctg ctg atg gct cag gaa ggc cat tgc aag gac tcc      48
  Met Ala Ile Gly Leu Leu Met Ala Gln Glu Gly His Cys Lys Asp Ser
    1               5                  10                  15

 tca gct atg gga gag gaa gca cat cac cca ttg acc ccc gca acc cct       96
 Ser Ala Met Gly Glu Glu Ala His His Pro Leu Thr Pro Ala Thr Pro
              20                  25                  30

 ccc ttt cct ccc ctg agt ccc gac tgg ggc cac atg cag cct gac ttc      144
 Pro Phe Pro Pro Leu Ser Pro Asp Trp Gly His Met Gln Pro Asp Phe
          35                  40                  45

 ttt gtg cct gtt gct gtc cct gca gtc ttc aga ggg cca ccg cag ctc      192
 Phe Val Pro Val Ala Val Pro Ala Val Phe Arg Gly Pro Pro Gln Leu
      50                  55                  60

 cag tgc cac ggc agg agg ctg ttc ctg aat agc ccc tgt gcc cag aaa      240
 Gln Cys His Gly Arg Arg Leu Phe Leu Asn Ser Pro Cys Ala Gln Lys
  65                  70                  75                  80

 tct tcc tct ggc cta gtt gtg gag cct ggc cta agt cgc aca ttg ctg      288
 Ser Ser Ser Gly Leu Val Val Glu Pro Gly Leu Ser Arg Thr Leu Leu
                  85                  90                  95

 gag atg gtg aag ctg acc agc atg aga ggt cag ttt cta gaa gcc caa      336
 Glu Met Val Lys Leu Thr Ser Met Arg Gly Gln Phe Leu Glu Ala Gln
             100                 105                 110

 atc cca aca ggc ata agc ctc acc ctc caa tat cag ctc tat cag aaa      384
 Ile Pro Thr Gly Ile Ser Leu Thr Leu Gln Tyr Gln Leu Tyr Gln Lys
         115                 120                 125

 caa aca aac aaa aac atg tct tat tca ttt gtc ctt ttc ctc aaa tgg      432
 Gln Thr Asn Lys Asn Met Ser Tyr Ser Phe Val Leu Phe Leu Lys Trp
     130                 135                 140

 gtg gca ctt ggg cag ggc aga agg gct ggt tat cca agc ttg gaa gat      480
 Val Ala Leu Gly Gln Gly Arg Arg Ala Gly Tyr Pro Ser Leu Glu Asp
 145                 150                 155                 160

 gct gac agc aga cgc ttc aat ggc agt agg agt ttt ctg atc act gtc      528
 Ala Asp Ser Arg Arg Phe Asn Gly Ser Arg Ser Phe Leu Ile Thr Val
                 165                 170                 175

 att ggt atc acg ctt act gtt gaa atc gtg aca tca gga atg atg aaa      576
 Ile Gly Ile Thr Leu Thr Val Glu Ile Val Thr Ser Gly Met Met Lys
             180                 185                 190

 gga act aga gtc aga tgg tct gga gcg ggg aat gag ggg atg atg ggg      624
 Gly Thr Arg Val Arg Trp Ser Gly Ala Gly Asn Glu Gly Met Met Gly
         195                 200                 205

 ctg gaa gag gga agg aat gaa agg agt gtg aag gaa gcg cca cca agg      672
 Leu Glu Glu Gly Arg Asn Glu Arg Ser Val Lys Glu Ala Pro Pro Arg
     210                 215                 220

 aga gct gtg gaa gcc caa ccc aaa gac cgc acc tgg gat gtc ggg aag      720
 Arg Ala Val Glu Ala Gln Pro Lys Asp Arg Thr Trp Asp Val Gly Lys
 225                 230                 235                 240

 ggc caa ggt aca gaa gga gaa gga aga ggg ttg gag gtg gag ggc cag      768
 Gly Gln Gly Thr Glu Gly Glu Gly Arg Gly Leu Glu Val Glu Gly Gln
                 245                 250                 255

 cag cac caa ggc tcg gag cca ggg aca ata cca ttc tct gtc tca tgg      816
 Gln His Gln Gly Ser Glu Pro Gly Thr Ile Pro Phe Ser Val Ser Trp
             260                 265                 270

 ggc gtc ctc ctg ctg gca ggc ctg tgc tgc ctg gtc ccc agc tcc ctg      864
 Gly Val Leu Leu Leu Ala Gly Leu Cys Cys Leu Val Pro Ser Ser Leu
         275                 280                 285

 gtt gag gat ccc cag gaa gat gct gcc caa aag acg gat aca tcc cac      912
 Val Glu Asp Pro Gln Glu Asp Ala Ala Gln Lys Thr Asp Thr Ser His
     290                 295                 300

 cat gat caa ggg gac tgg gag gac ctt gct tgc cag aag atc tcc tat      960
 His Asp Gln Gly Asp Trp Glu Asp Leu Ala Cys Gln Lys Ile Ser Tyr
 305                 310                 315                 320

 aac gtc acc gac ctc gcc ttt gat ttg tac aaa gag ctg gct gat cta     1008
 Asn Val Thr Asp Leu Ala Phe Asp Leu Tyr Lys Glu Leu Ala Asp Leu
                 325                 330                 335

 tca caa acc agc aat gtc tta gtc acc cca aca agc gtg gct atg gcc     1056
 Ser Gln Thr Ser Asn Val Leu Val Thr Pro Thr Ser Val Ala Met Ala
             340                 345                 350

 ttt gca atg ctc tcc ctg ggg acc aag gct gac act cgc aca gag atc     1104
 Phe Ala Met Leu Ser Leu Gly Thr Lys Ala Asp Thr Arg Thr Glu Ile
         355                 360                 365

 ctg gaa ggc ctg aat gtc aac ctc aca gag acg cct gag gcc aag atc     1152
 Leu Glu Gly Leu Asn Val Asn Leu Thr Glu Thr Pro Glu Ala Lys Ile
     370                 375                 380

 cac gaa tgc ttc cag caa gtt ctc caa gcc ctc agc agg cca gac acc     1200
 His Glu Cys Phe Gln Gln Val Leu Gln Ala Leu Ser Arg Pro Asp Thr
 385                 390                 395                 400

 cgg ctc cag ctg acc acc ggc agt agc ctg ttt gtt aac aag agt atg     1248
 Arg Leu Gln Leu Thr Thr Gly Ser Ser Leu Phe Val Asn Lys Ser Met
                 405                 410                 415

 aag cta gtg gac acg ttt ttg gag gat acc aag aag ctg tac cac tca     1296
 Lys Leu Val Asp Thr Phe Leu Glu Asp Thr Lys Lys Leu Tyr His Ser
             420                 425                 430

 gaa gcc tct tcc atc aac ttc agg gac acc gag gag gcc aaa gag cag     1344
 Glu Ala Ser Ser Ile Asn Phe Arg Asp Thr Glu Glu Ala Lys Glu Gln
         435                 440                 445

 atc aac aat tat gtg gag aaa aga act gga aga aaa gta gtg gat ttg     1392
 Ile Asn Asn Tyr Val Glu Lys Arg Thr Gly Arg Lys Val Val Asp Leu
     450                 455                 460

 gtc aaa cac ctg aaa aaa gac aca agt ctt gcc ctg gtg gat tac att     1440
 Val Lys His Leu Lys Lys Asp Thr Ser Leu Ala Leu Val Asp Tyr Ile
 465                 470                 475                 480

 tcc ttt cac ggc aag tgg aaa gat aaa ttc aag gct gag cgc att atg     1488
 Ser Phe His Gly Lys Trp Lys Asp Lys Phe Lys Ala Glu Arg Ile Met
                 485                 490                 495

 gta gag ggc ttc cat gtg gat gat aag acc atc atc aga gtg cct atg     1536
 Val Glu Gly Phe His Val Asp Asp Lys Thr Ile Ile Arg Val Pro Met
             500                 505                 510

 ata aac cac ctg ggt aga ttt gac atc cac cgg gac agg gag tta tcc     1584
 Ile Asn His Leu Gly Arg Phe Asp Ile His Arg Asp Arg Glu Leu Ser
         515                 520                 525

 agc tgg gtg ctg gca cag cac tat gtg ggg aac gcc act gcc ttc ttc     1632
 Ser Trp Val Leu Ala Gln His Tyr Val Gly Asn Ala Thr Ala Phe Phe
     530                 535                 540

 atc ctg ccc gat cca aag aag atg tgg cag ttg gaa gaa aaa ttg acc     1680
 Ile Leu Pro Asp Pro Lys Lys Met Trp Gln Leu Glu Glu Lys Leu Thr
 545                 550                 555                 560

 tac agc cac ctt gaa aat atc cag aga gcc ttt gac ata agg tct atc     1728
 Tyr Ser His Leu Glu Asn Ile Gln Arg Ala Phe Asp Ile Arg Ser Ile
                 565                 570                 575

 aat cta cat ttt ccc aaa ctg tcc att tct gga acc tac aaa ctc aag     1776
 Asn Leu His Phe Pro Lys Leu Ser Ile Ser Gly Thr Tyr Lys Leu Lys
             580                 585                 590

 aga gtc cct agg aat ctg ggc atc act aag atc ttc agc aat ggg gct     1824
 Arg Val Pro Arg Asn Leu Gly Ile Thr Lys Ile Phe Ser Asn Gly Ala
         595                 600                 605

 gac ctc tcc ggg gtc aga gag gag gca ccc ctg aag ctc tcc aag gcc     1872
 Asp Leu Ser Gly Val Arg Glu Glu Ala Pro Leu Lys Leu Ser Lys Ala
     610                 615                 620

 gtg cat aag gct gtg ctg acc atc gac gaa aaa ggg act gaa gct gct     1920
 Val His Lys Ala Val Leu Thr Ile Asp Glu Lys Gly Thr Glu Ala Ala
 625                 630                 635                 640

 ggg gcc atg ttt tta gag gcc ata ccc atg tct atc ccc ccc ggg gtc     1968
 Gly Ala Met Phe Leu Glu Ala Ile Pro Met Ser Ile Pro Pro Gly Val
                 645                 650                 655

 aag ttc aaa aaa ccc ttt gtc ttc tta atg att gaa caa aat acc aag     2016
 Lys Phe Lys Lys Pro Phe Val Phe Leu Met Ile Glu Gln Asn Thr Lys
             660                 665                 670

 tct ccc ctc ttc atg gga aaa gtg gtg aat ccc acc caa aaa taa         2061
 Ser Pro Leu Phe Met Gly Lys Val Val Asn Pro Thr Gln Lys 
         675                 680                 685





      <210> 181
      <211> 1701
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (1)..(1701)

      <400> 181
  atg aga agg cag tgg ggg tct gcc atg agg gcg gcc gag cag gcg ggc      48
  Met Arg Arg Gln Trp Gly Ser Ala Met Arg Ala Ala Glu Gln Ala Gly
    1               5                  10                  15

 tgc atg gtg agc gcc tcc cgg gcc gga cag ccc gag gcg ggc ccg tgg       96
 Cys Met Val Ser Ala Ser Arg Ala Gly Gln Pro Glu Ala Gly Pro Trp
              20                  25                  30

 agc tgc agc ggg gta atc ctg agc cgt agc ccg ggc ctg gtg ctt tgc      144
 Ser Cys Ser Gly Val Ile Leu Ser Arg Ser Pro Gly Leu Val Leu Cys
          35                  40                  45

 cac ggg ggc atc ttc gtc ccc ttc ctg cga gct ggc agc gaa gtc ctg      192
 His Gly Gly Ile Phe Val Pro Phe Leu Arg Ala Gly Ser Glu Val Leu
      50                  55                  60

 gcc gcg gcc ggc gcc gtc ttc ctg cct ggc gac agt tgc agg gac gac      240
 Ala Ala Ala Gly Ala Val Phe Leu Pro Gly Asp Ser Cys Arg Asp Asp
  65                  70                  75                  80

 ctg cgc ctg cac gtg cag tgg gcc cca acg gcc gcg ggt ccc ggg ggc      288
 Leu Arg Leu His Val Gln Trp Ala Pro Thr Ala Ala Gly Pro Gly Gly
                  85                  90                  95

 ggc gcg gag cgg ggc cgc cca ggg ctg tgc acg ccc cag tgc gcg agc      336
 Gly Ala Glu Arg Gly Arg Pro Gly Leu Cys Thr Pro Gln Cys Ala Ser
             100                 105                 110

 ctc gag ccc ggc cca cct gcc ccg tcc cgc ggg cgt ccc ctg cag ccc      384
 Leu Glu Pro Gly Pro Pro Ala Pro Ser Arg Gly Arg Pro Leu Gln Pro
         115                 120                 125

 cgg ctt cct gct gag ctg ctg ctg ctg ctg agc tgc ccg gcc ttc tgg      432
 Arg Leu Pro Ala Glu Leu Leu Leu Leu Leu Ser Cys Pro Ala Phe Trp
     130                 135                 140

 gcc cac ttc gcg cgc ctc ttc ggg gac gag gca gcg gaa cag tgg cgc      480
 Ala His Phe Ala Arg Leu Phe Gly Asp Glu Ala Ala Glu Gln Trp Arg
 145                 150                 155                 160

 ttc tcg agc gcg gcg cgg gat gac gaa gtg tcg gag gac gag gag gcg      528
 Phe Ser Ser Ala Ala Arg Asp Asp Glu Val Ser Glu Asp Glu Glu Ala
                 165                 170                 175

 gat caa ctg aga gcg ctg ggc tgg ttt gcg ctg ctg ggc gtg cgg cta      576
 Asp Gln Leu Arg Ala Leu Gly Trp Phe Ala Leu Leu Gly Val Arg Leu
             180                 185                 190

 ggc cag gag gag gtg gag gag gag cgc ggg cca gcc atg gcg gtg tcg      624
 Gly Gln Glu Glu Val Glu Glu Glu Arg Gly Pro Ala Met Ala Val Ser
         195                 200                 205

 cct ctc ggg gcc gtg ccc aag ggt gcg cca ttg ctg gtc tgc ggc tcc      672
 Pro Leu Gly Ala Val Pro Lys Gly Ala Pro Leu Leu Val Cys Gly Ser
     210                 215                 220

 cct ttc ggc gcc ttc tgc ccc gac atc ttt ctc aac acg ctg agc tgc      720
 Pro Phe Gly Ala Phe Cys Pro Asp Ile Phe Leu Asn Thr Leu Ser Cys
 225                 230                 235                 240

 ggg gtg ctc agc aac gtg gcc ggc cca ctg ctg ctt acc gac gca cgc      768
 Gly Val Leu Ser Asn Val Ala Gly Pro Leu Leu Leu Thr Asp Ala Arg
                 245                 250                 255

 tgc ctg ccc ggc acc gag ggc ggc ggc gtg ttc acc gcg cgg ccc gcg      816
 Cys Leu Pro Gly Thr Glu Gly Gly Gly Val Phe Thr Ala Arg Pro Ala
             260                 265                 270

 ggg gcg ctg gtg gcg ctg gtg gtg gcg ccg ctc tgt tgg aag gcc ggc      864
 Gly Ala Leu Val Ala Leu Val Val Ala Pro Leu Cys Trp Lys Ala Gly
         275                 280                 285

 gaa tgg gtg ggc ttc acg ctg ctc tgc gcc gcc gcc ccc ctt ttc cgc      912
 Glu Trp Val Gly Phe Thr Leu Leu Cys Ala Ala Ala Pro Leu Phe Arg
     290                 295                 300

 gcc gcc cgc gac gcg ctt cac cgc ctg ccg cac agc acc gct gcc ctg      960
 Ala Ala Arg Asp Ala Leu His Arg Leu Pro His Ser Thr Ala Ala Leu
 305                 310                 315                 320

 gcc gcc ctt ctg ccg cca gag gtg ggc gtc ccg tgg ggt ctg ccc ctc     1008
 Ala Ala Leu Leu Pro Pro Glu Val Gly Val Pro Trp Gly Leu Pro Leu
                 325                 330                 335

 cga gac tcc ggg ccc ctg tgg gca gcc gcg gca gtg ttg gtg gag tgc     1056
 Arg Asp Ser Gly Pro Leu Trp Ala Ala Ala Ala Val Leu Val Glu Cys
             340                 345                 350

 ggc acc gta tgg ggc tcc gga gtg gct gtg gca ccc cgc ctt gta gtg     1104
 Gly Thr Val Trp Gly Ser Gly Val Ala Val Ala Pro Arg Leu Val Val
         355                 360                 365

 acc tgt cgg cac gtg tcc cct cgg gaa gca gcc agg gtc ctg gtg cgc     1152
 Thr Cys Arg His Val Ser Pro Arg Glu Ala Ala Arg Val Leu Val Arg
     370                 375                 380

 tcc acc acc ccc aag agt gtg gcc atc tgg ggc cgt gtg gta ttt gcc     1200
 Ser Thr Thr Pro Lys Ser Val Ala Ile Trp Gly Arg Val Val Phe Ala
 385                 390                 395                 400

 act cag gag aca tgt ccc tat gac ata gca gtg gtg agc ctg gag gag     1248
 Thr Gln Glu Thr Cys Pro Tyr Asp Ile Ala Val Val Ser Leu Glu Glu
                 405                 410                 415

 gac ctg gat gat gtc ccc atc cct gtg ccc gct gag cac ttc cat gaa     1296
 Asp Leu Asp Asp Val Pro Ile Pro Val Pro Ala Glu His Phe His Glu
             420                 425                 430

 ggc gag gct gtg agt gtg gtg ggc ttt ggc gtc ttt ggc cag tct tgc     1344
 Gly Glu Ala Val Ser Val Val Gly Phe Gly Val Phe Gly Gln Ser Cys
         435                 440                 445

 ggg ccc tcg gtg acc tca ggc atc ctt tcg gct gtg gtg cag gtg aat     1392
 Gly Pro Ser Val Thr Ser Gly Ile Leu Ser Ala Val Val Gln Val Asn
     450                 455                 460

 ggc acg ccc gta atg ctg cag acc acg tgt gct gtg cac agc ggc tcc     1440
 Gly Thr Pro Val Met Leu Gln Thr Thr Cys Ala Val His Ser Gly Ser
 465                 470                 475                 480

 agt ggg gga ccc ctc ttc tcc aac cac tca gga aac ctc ctt ggc ata     1488
 Ser Gly Gly Pro Leu Phe Ser Asn His Ser Gly Asn Leu Leu Gly Ile
                 485                 490                 495

 atc acc agc aac acc cgg gac aat aat acg ggg gcc acc tac ccc cac     1536
 Ile Thr Ser Asn Thr Arg Asp Asn Asn Thr Gly Ala Thr Tyr Pro His
             500                 505                 510

 ctg aac ttc agc att ccc atc acg gtg ctc cag ccg gcc ctg cag cag     1584
 Leu Asn Phe Ser Ile Pro Ile Thr Val Leu Gln Pro Ala Leu Gln Gln
         515                 520                 525

 tac agc cag acc caa gac cta ggt ggc ctc cgt gag ctg gac cgc gct     1632
 Tyr Ser Gln Thr Gln Asp Leu Gly Gly Leu Arg Glu Leu Asp Arg Ala
     530                 535                 540

 gct gag cca gtc agg gtg gtg tgg cgg ttg cag cgg ccc ctg gca gag     1680
 Ala Glu Pro Val Arg Val Val Trp Arg Leu Gln Arg Pro Leu Ala Glu
 545                 550                 555                 560

 gcc ccg cgg agc aag ctc tga                                         1701
 Ala Pro Arg Ser Lys Leu 
                 565





      <210> 182
      <211> 1507
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (219)..(1106)

      <400> 182
 ggttttggcc tccggctgtc ccgctccggc tcctggggct ccccgcagac gctgcttttc     60

 ttgctccact gggggtgcct cttcctgggc gcccgccgcg ctgcatcctg ctcgccctgt    120

 ctgggaatgg ggccgccccc gggcttgggc cggcccggct ggggcccccg aggcgcttcc    180

 gccccgtagt gaccgcctgg tgccgccccc cccccagg    atg aag ggc ggc gag     233
                                              Met Lys Gly Gly Glu
                                                1               5

 ggg gac gcg ggc gag cag gcc ccg ctg aac cct gag ggc gag agc cct      281
 Gly Asp Ala Gly Glu Gln Ala Pro Leu Asn Pro Glu Gly Glu Ser Pro
                  10                  15                  20

 gca ggc tcg gcc acg tac cgg gag ttc gtg cac cgc ggc tac ctg gac      329
 Ala Gly Ser Ala Thr Tyr Arg Glu Phe Val His Arg Gly Tyr Leu Asp
              25                  30                  35

 ctc atg ggg gcc agt cag cac tcg ctg cgg gcg ctc agc tgg cgc cgc      377
 Leu Met Gly Ala Ser Gln His Ser Leu Arg Ala Leu Ser Trp Arg Arg
          40                  45                  50

 ctc tac ctc agc cgg gcc aag ctc aaa gct tcc agc cgc acg tct gcc      425
 Leu Tyr Leu Ser Arg Ala Lys Leu Lys Ala Ser Ser Arg Thr Ser Ala
      55                  60                  65

 ttg ctc tcg ggc ttc gcc atg gtg gcc atg gtg gag gtg cag ctg gag      473
 Leu Leu Ser Gly Phe Ala Met Val Ala Met Val Glu Val Gln Leu Glu
  70                  75                  80                  85

 agt gac cac gag tac cca cca ggc ctg ctg gtg gcc ttc agt gcc tgc      521
 Ser Asp His Glu Tyr Pro Pro Gly Leu Leu Val Ala Phe Ser Ala Cys
                  90                  95                 100

 acc acc gtg ctg gtg gct gtg cac ctc ttt gca ctc atg gtc tcc acg      569
 Thr Thr Val Leu Val Ala Val His Leu Phe Ala Leu Met Val Ser Thr
             105                 110                 115

 tgt ctg ctg ccc cac att gaa gct gtg agc aac atc cac aac ctc aac      617
 Cys Leu Leu Pro His Ile Glu Ala Val Ser Asn Ile His Asn Leu Asn
         120                 125                 130

 tct gtc cac cag tcg cca cac cag aga ctg cac cgc tac gtg gag ctg      665
 Ser Val His Gln Ser Pro His Gln Arg Leu His Arg Tyr Val Glu Leu
     135                 140                 145

 gcc tgg ggc ttc tcc act gcc ctg ggc acc ttt ctc ttc ctt gct gaa      713
 Ala Trp Gly Phe Ser Thr Ala Leu Gly Thr Phe Leu Phe Leu Ala Glu
 150                 155                 160                 165

 gtt gtc ctg gtt ggt tgg gtc aag ttt gtg ccc att ggg gct ccc ttg      761
 Val Val Leu Val Gly Trp Val Lys Phe Val Pro Ile Gly Ala Pro Leu
                 170                 175                 180

 gac aca ccg acc ccc atg gtg ccc aca tcc cgg gtg ccc ggg act ctg      809
 Asp Thr Pro Thr Pro Met Val Pro Thr Ser Arg Val Pro Gly Thr Leu
             185                 190                 195

 gca cca gtg gct acc tcc ctt agt cca gct tcc aat ctc cca cgg tcc      857
 Ala Pro Val Ala Thr Ser Leu Ser Pro Ala Ser Asn Leu Pro Arg Ser
         200                 205                 210

 tct gcg tct gca gca ccg tcc cag gct gag cca gcc tgc cca ccc cgg      905
 Ser Ala Ser Ala Ala Pro Ser Gln Ala Glu Pro Ala Cys Pro Pro Arg
     215                 220                 225

 caa gcc tgt ggt ggt ggt ggg gcc cat ggg cca ggc tgg caa gca gcc      953
 Gln Ala Cys Gly Gly Gly Gly Ala His Gly Pro Gly Trp Gln Ala Ala
 230                 235                 240                 245

 atg gcc tcc aca gcc atc atg gta ccc gtg ggg ctc gtg ttt gtg gcc     1001
 Met Ala Ser Thr Ala Ile Met Val Pro Val Gly Leu Val Phe Val Ala
                 250                 255                 260

 ttt gcc ctg cat ttc tac cgc tcc ttg gtg gca cac aag aca gac cgc     1049
 Phe Ala Leu His Phe Tyr Arg Ser Leu Val Ala His Lys Thr Asp Arg
             265                 270                 275

 tac aag cag gaa cta gag gaa ctg aat cgc ctg cag ggg gag ctg cag     1097
 Tyr Lys Gln Glu Leu Glu Glu Leu Asn Arg Leu Gln Gly Glu Leu Gln
         280                 285                 290

 gct gtg tga gactggt gttagccacc gctcactgca agcactgcct ccctccgggg     1153
 Ala Val 
     295

 tctgtaagag gccgcagggg cctacagacc tcatcccccc atcccctggc tggagccact   1213

 tccagtggcc actctcaggc agagttcaga ttcctgcccg cagggtcctc tgggctgggc   1273

 cttggggcag ctcccacatt cccagggatt ttccccatca gtctgtccct tgggttttgc   1333

 aagctactct gcacctgggc tggcctcagt tgaaggatca tgcagtagat agaggggagg   1393

 cagggagagc ttgtgggacc ttcagtgctg actttagcca ccatttccat tcctatacag   1453

 gatgtgaagg tcagaaggca gccaattgtt ggtttaattt tttttttttt ttga         1507




      <210> 183
      <211> 1686
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (1)..(1686)

      <400> 183
  atg gca aat atg aat agt gat tct agg cat ctt ggc acc tct gag gta      48
  Met Ala Asn Met Asn Ser Asp Ser Arg His Leu Gly Thr Ser Glu Val
    1               5                  10                  15

 gat cat gaa aga gat cct gga cct atg aat atc cag ttt gag cca tcg       96
 Asp His Glu Arg Asp Pro Gly Pro Met Asn Ile Gln Phe Glu Pro Ser
              20                  25                  30

 gat cta aga tcc aaa agg cct ttc tgt ata gag ccc aca aac atc gtg      144
 Asp Leu Arg Ser Lys Arg Pro Phe Cys Ile Glu Pro Thr Asn Ile Val
          35                  40                  45

 aat gtg aat cat gtc att cag agg gtt agt gac cat gcc tct gcc atg      192
 Asn Val Asn His Val Ile Gln Arg Val Ser Asp His Ala Ser Ala Met
      50                  55                  60

 aac aag aga att cat tac tac agc cgg ctc acc act cct gca gac aag      240
 Asn Lys Arg Ile His Tyr Tyr Ser Arg Leu Thr Thr Pro Ala Asp Lys
  65                  70                  75                  80

 gca ctg att gcc cca gac cat gta gtt cca gct cca gaa gag tgc tat      288
 Ala Leu Ile Ala Pro Asp His Val Val Pro Ala Pro Glu Glu Cys Tyr
                  85                  90                  95

 gtg tat agt cca ttg ggc tct gct tat aaa ctt caa agt tac act gaa      336
 Val Tyr Ser Pro Leu Gly Ser Ala Tyr Lys Leu Gln Ser Tyr Thr Glu
             100                 105                 110

 gga tac ggt aaa aac acc agt tta gta acc att ttt atg att tgg aat      384
 Gly Tyr Gly Lys Asn Thr Ser Leu Val Thr Ile Phe Met Ile Trp Asn
         115                 120                 125

 acc atg atg gga aca tct ata cta agc att cct tgg ggc ata aaa cag      432
 Thr Met Met Gly Thr Ser Ile Leu Ser Ile Pro Trp Gly Ile Lys Gln
     130                 135                 140

 gct gga ttt act act gga atg tgt gtc atc ata ctg atg ggc ctt tta      480
 Ala Gly Phe Thr Thr Gly Met Cys Val Ile Ile Leu Met Gly Leu Leu
 145                 150                 155                 160

 aca ctt tat tgc tgc tac aga gta gtg aaa tca cgg act atg atg ttt      528
 Thr Leu Tyr Cys Cys Tyr Arg Val Val Lys Ser Arg Thr Met Met Phe
                 165                 170                 175

 tcg ttg gat acc act agc tgg gaa tat cca gat gtc tgc aga cat tat      576
 Ser Leu Asp Thr Thr Ser Trp Glu Tyr Pro Asp Val Cys Arg His Tyr
             180                 185                 190

 ttc ggc tcc ttt ggg cag tgg tcg agt ctc ctt ttc tcc ttg gtg tct      624
 Phe Gly Ser Phe Gly Gln Trp Ser Ser Leu Leu Phe Ser Leu Val Ser
         195                 200                 205

 ctc att gga gca atg ata gtt tat tgg gtg ctt atg tca aat ttt ctt      672
 Leu Ile Gly Ala Met Ile Val Tyr Trp Val Leu Met Ser Asn Phe Leu
     210                 215                 220

 ttt aat act gga aag ttt att ttt aat ttt att cat cac att aat gac      720
 Phe Asn Thr Gly Lys Phe Ile Phe Asn Phe Ile His His Ile Asn Asp
 225                 230                 235                 240

 aca gac act ata ctg agt acc aat aat agc aac cct gtg att tgt cca      768
 Thr Asp Thr Ile Leu Ser Thr Asn Asn Ser Asn Pro Val Ile Cys Pro
                 245                 250                 255

 agt gcc ggg agt gga ggc cat cct gac aac agc tct atg att ttc tat      816
 Ser Ala Gly Ser Gly Gly His Pro Asp Asn Ser Ser Met Ile Phe Tyr
             260                 265                 270

 gcc aat gac aca gga gcc caa cag ttt gaa aag tgg tgg gat aag tcc      864
 Ala Asn Asp Thr Gly Ala Gln Gln Phe Glu Lys Trp Trp Asp Lys Ser
         275                 280                 285

 agg aca gtc ccc ttt tat ctt gta ggg ctc ctc ctc cca ctg ctc aat      912
 Arg Thr Val Pro Phe Tyr Leu Val Gly Leu Leu Leu Pro Leu Leu Asn
     290                 295                 300

 ttc aag tct cct tca ttt ttt tca aaa ttt aat atc cta ggc aca gtg      960
 Phe Lys Ser Pro Ser Phe Phe Ser Lys Phe Asn Ile Leu Gly Thr Val
 305                 310                 315                 320

 tct gtc ctt tat ttg att ttc ctt gtc acc ttt aag gct gtt cgc ttg     1008
 Ser Val Leu Tyr Leu Ile Phe Leu Val Thr Phe Lys Ala Val Arg Leu
                 325                 330                 335

 gga ttt cat ttg gaa ttt cat tgg ttt ata cca aca gaa ttt ttt gta     1056
 Gly Phe His Leu Glu Phe His Trp Phe Ile Pro Thr Glu Phe Phe Val
             340                 345                 350

 cca gag ata aga ttt cag ttt cca cag ctg act gga gtg ctt acc ctt     1104
 Pro Glu Ile Arg Phe Gln Phe Pro Gln Leu Thr Gly Val Leu Thr Leu
         355                 360                 365

 gct ttt ttt att cat aat tgt atc atc aca ctc ttg aag aac aac aag     1152
 Ala Phe Phe Ile His Asn Cys Ile Ile Thr Leu Leu Lys Asn Asn Lys
     370                 375                 380

 aaa caa gaa aac aat gtg agg gac ttg tgc att gct tat atg ctg gtg     1200
 Lys Gln Glu Asn Asn Val Arg Asp Leu Cys Ile Ala Tyr Met Leu Val
 385                 390                 395                 400

 aca tta act tat ctc tat att gga gtc ctg gtt ttt gct tca ttt cct     1248
 Thr Leu Thr Tyr Leu Tyr Ile Gly Val Leu Val Phe Ala Ser Phe Pro
                 405                 410                 415

 tca cca cca tta tcc aaa gat tgt att gag cag aat ttt tta gac aac     1296
 Ser Pro Pro Leu Ser Lys Asp Cys Ile Glu Gln Asn Phe Leu Asp Asn
             420                 425                 430

 ttc cct agc agt gac acc ctg tcc ttc att gca agg ata ttc ctg ctg     1344
 Phe Pro Ser Ser Asp Thr Leu Ser Phe Ile Ala Arg Ile Phe Leu Leu
         435                 440                 445

 ttc cag atg atg act gta tac cca ctc tta ggc tac ctg gct cgt gtc     1392
 Phe Gln Met Met Thr Val Tyr Pro Leu Leu Gly Tyr Leu Ala Arg Val
     450                 455                 460

 cag ctt ttg ggc cat atc ttc ggt gac att tat cct agc att ttc cat     1440
 Gln Leu Leu Gly His Ile Phe Gly Asp Ile Tyr Pro Ser Ile Phe His
 465                 470                 475                 480

 gtg ctg att ctt aat cta att att gtg gga gct gga gtg atc atg gcc     1488
 Val Leu Ile Leu Asn Leu Ile Ile Val Gly Ala Gly Val Ile Met Ala
                 485                 490                 495

 tgt ttc tac cca aac ata gga ggg atc ata aga tat tca gga gca gca     1536
 Cys Phe Tyr Pro Asn Ile Gly Gly Ile Ile Arg Tyr Ser Gly Ala Ala
             500                 505                 510

 tgt gga ctg gcc ttt gta ttc ata tac cca tct ctc atc tat ata att     1584
 Cys Gly Leu Ala Phe Val Phe Ile Tyr Pro Ser Leu Ile Tyr Ile Ile
         515                 520                 525

 tcc ctc cac caa gaa gag cgt ctg aca tgg cct aaa tta atc ttc cac     1632
 Ser Leu His Gln Glu Glu Arg Leu Thr Trp Pro Lys Leu Ile Phe His
     530                 535                 540

 gtt ttc atc atc att ttg ggc gtg gct aac ctg att gtt cag ttt ttt     1680
 Val Phe Ile Ile Ile Leu Gly Val Ala Asn Leu Ile Val Gln Phe Phe
 545                 550                 555                 560

 atg tga                                                             1686
 Met 






      <210> 184
      <211> 1268
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (142)..(1251)

      <400> 184
 agtaaacaaa taaggtatga tctcgtgaaa tcttgagaga aactgaatga cgaatgaaac     60

 tattgttcct gtttcacaca gaagaaaact gaggttaaaa ggggttggca ctcatcatga    120

 gcccctgttc tcattctgca a  atg gtg aag ctc tct att gtc ctg acc cca     171
                          Met Val Lys Leu Ser Ile Val Leu Thr Pro
                            1               5                  10

 cag ttc ctg tcc cat gac cag ggc cag ctc acc aag gag ctg cag cag      219
 Gln Phe Leu Ser His Asp Gln Gly Gln Leu Thr Lys Glu Leu Gln Gln
                  15                  20                  25

 cat gta aag tca gtg aca tgc cca tgc gag tac ctg agg aag gtt atc      267
 His Val Lys Ser Val Thr Cys Pro Cys Glu Tyr Leu Arg Lys Val Ile
              30                  35                  40

 aat act ctg gct gac cat cat cat cgt ggg act gac ttt ggt gga agt      315
 Asn Thr Leu Ala Asp His His His Arg Gly Thr Asp Phe Gly Gly Ser
          45                  50                  55

 cct tgg tta cat gtc att att gcg ttt ccg aca agt tat aaa gtt gtc      363
 Pro Trp Leu His Val Ile Ile Ala Phe Pro Thr Ser Tyr Lys Val Val
      60                  65                  70

 att acc ctc tgg ata gtt tac ctt tgg gtg tct ctc ctg aag act atc      411
 Ile Thr Leu Trp Ile Val Tyr Leu Trp Val Ser Leu Leu Lys Thr Ile
  75                  80                  85                  90

 ttc tgg tct cga aat gga cat gat gga tcc acg gat gta cag cag aga      459
 Phe Trp Ser Arg Asn Gly His Asp Gly Ser Thr Asp Val Gln Gln Arg
                  95                 100                 105

 gcc agg agg tcc aac cgc cgt aga cag gaa gga att aaa att gtc ctg      507
 Ala Arg Arg Ser Asn Arg Arg Arg Gln Glu Gly Ile Lys Ile Val Leu
             110                 115                 120

 gaa gac atc ttt act tta tgg aga cag gtg gaa acc aaa gtt cga gct      555
 Glu Asp Ile Phe Thr Leu Trp Arg Gln Val Glu Thr Lys Val Arg Ala
         125                 130                 135

 aaa atc cgt aag atg aag gtg aca aca aaa gtc aac cgt cat gac aaa      603
 Lys Ile Arg Lys Met Lys Val Thr Thr Lys Val Asn Arg His Asp Lys
     140                 145                 150

 atc aat gga aag agg aag acc gcc aaa gaa cat ctg agg aaa cta agc      651
 Ile Asn Gly Lys Arg Lys Thr Ala Lys Glu His Leu Arg Lys Leu Ser
 155                 160                 165                 170

 atg aaa gaa cgt gag cac gga gaa aag gag agg cag gtg tca gag gca      699
 Met Lys Glu Arg Glu His Gly Glu Lys Glu Arg Gln Val Ser Glu Ala
                 175                 180                 185

 gag gaa aat ggg aaa ttg gat atg aaa gaa ata cac acc tac atg gaa      747
 Glu Glu Asn Gly Lys Leu Asp Met Lys Glu Ile His Thr Tyr Met Glu
             190                 195                 200

 atg ttt caa cgt gcg caa gcg ttg cgg cgg cgg gca gag gac tac tac      795
 Met Phe Gln Arg Ala Gln Ala Leu Arg Arg Arg Ala Glu Asp Tyr Tyr
         205                 210                 215

 aga tgc aaa atc acc cct tct gca aga aag cct ctt tgc aac cgg gtc      843
 Arg Cys Lys Ile Thr Pro Ser Ala Arg Lys Pro Leu Cys Asn Arg Val
     220                 225                 230

 aga atg gcg gca gtg gag cat cgt cat tct tca gga ttg ccc tac tgg      891
 Arg Met Ala Ala Val Glu His Arg His Ser Ser Gly Leu Pro Tyr Trp
 235                 240                 245                 250

 ccc tac ctc aca gct gaa act tta aaa aac agg atg ggc cac cag cca      939
 Pro Tyr Leu Thr Ala Glu Thr Leu Lys Asn Arg Met Gly His Gln Pro
                 255                 260                 265

 cct cct cca act caa caa cat tct ata att gat aac tcc ctg agc ctc      987
 Pro Pro Pro Thr Gln Gln His Ser Ile Ile Asp Asn Ser Leu Ser Leu
             270                 275                 280

 aag aca cct tcc gag tgt ctg ctc act ccc ctt cca ccc tca gct cta     1035
 Lys Thr Pro Ser Glu Cys Leu Leu Thr Pro Leu Pro Pro Ser Ala Leu
         285                 290                 295

 ccc tca gcg gat gat aat ctc aag aca cct gcg gag tgt ctg ctc tat     1083
 Pro Ser Ala Asp Asp Asn Leu Lys Thr Pro Ala Glu Cys Leu Leu Tyr
     300                 305                 310

 ccc ctt cca ccc tca gcg gat gat aat ctc aag aca cct ccc gag tgt     1131
 Pro Leu Pro Pro Ser Ala Asp Asp Asn Leu Lys Thr Pro Pro Glu Cys
 315                 320                 325                 330

 ctg ctc act ccc ctt cca ccc tca gct cca ccc tca gcg gat gat aat     1179
 Leu Leu Thr Pro Leu Pro Pro Ser Ala Pro Pro Ser Ala Asp Asp Asn
                 335                 340                 345

 ctc aag aca cct ccc gag tgt gtc tgc tca ctc ccc ttc cac cct cag     1227
 Leu Lys Thr Pro Pro Glu Cys Val Cys Ser Leu Pro Phe His Pro Gln
             350                 355                 360

 cgg atg ata atc tca aga aac taa ggaagaataa ataaata                  1268
 Arg Met Ile Ile Ser Arg Asn 
         365





      <210> 185
      <211> 1311
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (54)..(872)

      <400> 185
 ggtattttgg aaaaatggta aagaagtgca gagtcaagtc atagcgacta ata   atg      56
                                                              Met
                                                                1

 ggt tat ttt ctt aaa ttg tat gct tat gtt aat tct cac agt ctt ttt      104
 Gly Tyr Phe Leu Lys Leu Tyr Ala Tyr Val Asn Ser His Ser Leu Phe
               5                  10                  15

 gtt tgg gtc tgt gac aga tct tac aaa aga tct ttt aga cct atg att      152
 Val Trp Val Cys Asp Arg Ser Tyr Lys Arg Ser Phe Arg Pro Met Ile
          20                  25                  30

 ctt aac aaa att aaa gaa tta agt cgg aac caa ttt ccc aca atg tct      200
 Leu Asn Lys Ile Lys Glu Leu Ser Arg Asn Gln Phe Pro Thr Met Ser
      35                  40                  45

 cat cta aga aag gac tca cag ccc agc agc cca gga gat gac gca atg      248
 His Leu Arg Lys Asp Ser Gln Pro Ser Ser Pro Gly Asp Asp Ala Met
  50                  55                  60                  65

 gac agg agt ggg ctc cct gac ctt caa gga aga ttt gag cta tct ggg      296
 Asp Arg Ser Gly Leu Pro Asp Leu Gln Gly Arg Phe Glu Leu Ser Gly
                  70                  75                  80

 aaa aac aga cag tat cca ctg gat gca ttg gaa ccc caa ccc agc att      344
 Lys Asn Arg Gln Tyr Pro Leu Asp Ala Leu Glu Pro Gln Pro Ser Ile
              85                  90                  95

 ggg gat att aag gac att aaa aaa gca gcc aag tct atg cta gac cca      392
 Gly Asp Ile Lys Asp Ile Lys Lys Ala Ala Lys Ser Met Leu Asp Pro
         100                 105                 110

 gca cat aaa tct cat ttc cac cct gtg acc cca agt tta gta ttc ttg      440
 Ala His Lys Ser His Phe His Pro Val Thr Pro Ser Leu Val Phe Leu
     115                 120                 125

 tgt ttc ata ttt gat ggg tta cac cag gca tta ctg agt gtt ggt gtg      488
 Cys Phe Ile Phe Asp Gly Leu His Gln Ala Leu Leu Ser Val Gly Val
 130                 135                 140                 145

 agc aag agg tct aat act gtg gtt ggg aat gag aac gag gaa agg ggt      536
 Ser Lys Arg Ser Asn Thr Val Val Gly Asn Glu Asn Glu Glu Arg Gly
                 150                 155                 160

 act cct tat gct agc aga ttc aaa gat atg cct aac ttt att gcc ctt      584
 Thr Pro Tyr Ala Ser Arg Phe Lys Asp Met Pro Asn Phe Ile Ala Leu
             165                 170                 175

 gag aag tca tca gtt ctc cgc cac tgc tgt gac ctt ttg ata ggc att      632
 Glu Lys Ser Ser Val Leu Arg His Cys Cys Asp Leu Leu Ile Gly Ile
         180                 185                 190

 gcg gct gga tca agt gat aag att tgc acc agc agt ctc caa gtt cag      680
 Ala Ala Gly Ser Ser Asp Lys Ile Cys Thr Ser Ser Leu Gln Val Gln
     195                 200                 205

 aga cga ttc aag gca atg atg gca tct att gga aga ctt tca cat ggt      728
 Arg Arg Phe Lys Ala Met Met Ala Ser Ile Gly Arg Leu Ser His Gly
 210                 215                 220                 225

 gag agt gct gat ctg cta atc agc tgc aat gca gaa tca gcc ata ggt      776
 Glu Ser Ala Asp Leu Leu Ile Ser Cys Asn Ala Glu Ser Ala Ile Gly
                 230                 235                 240

 tgg atc agc tca aga cca tgg gtt gga gaa tta atg ttc aca ttt cta      824
 Trp Ile Ser Ser Arg Pro Trp Val Gly Glu Leu Met Phe Thr Phe Leu
             245                 250                 255

 ttt gga gac ttt gaa tcc cct cta cac aag cta cgc aag tca agt tag      872
 Phe Gly Asp Phe Glu Ser Pro Leu His Lys Leu Arg Lys Ser Ser 
         260                 265                 270

 ttgccaagaa agcacagatg acaacctatt aatgctgtga gaatgtttct agatcagtgc    932

 atggatggct ccattgctct acgggccatt gtgtctgaga tcccagtctt tgaggagaaa    992

 aaaaacaatg gttaaaaagg cattggggaa atattttgag tttgggggtg tactttgcca   1052

 ccccattatt ggggagctgt caccacgaat gttcccaaac ttagcaacag cggcaaacta   1112

 ctgggccaag atgagcaacc ccacattttt gggatttaaa gctcctgatg ttataccagg   1172

 atcaaccatc acactccctt tgcttcaaat ggcatctacc ccgtaagatc ttgagggggg   1232

 agtgttgggt ggaatcatag atccatgcac tcctaacatg aactaattct cattatttaa   1292

 aaaaaaaaaa aaaaaaaaa                                                1311




      <210> 186
      <211> 909
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (323)..(748)

      <400> 186
 cagtaattcg gcacgaggcc acgttacgga tcggcttact ccgcggagtt ggcctcattt     60

 ctgcagtcgg cgctccctgt agtttctcct ctcgaacgcc aggtggagca accggccgga    120

 taccgccaca gccctggcag gcggcgctgt gatgcctgag ctgatcctgt atgttgcaat    180

 cactctatcc gtggctgagc gactcgttgg cccgggtcac gcatgcgctg agccttcctt    240

 tcgctcttcc cgctgctccg cccctctctg tcttctctgc agtgggagca gctctcctgc    300

 cacagctcct caccccctga aa atg ttc gcc tgc tcc aag ttt gtc tcc act     352
                          Met Phe Ala Cys Ser Lys Phe Val Ser Thr
                            1               5                  10

 ccc tcc ttg gtc aat agg gcc tta cag ctg ctg agc cgt ccg cta tct      400
 Pro Ser Leu Val Asn Arg Ala Leu Gln Leu Leu Ser Arg Pro Leu Ser
                  15                  20                  25

 gca atg gtg ctg aaa cga ccg gag ata ctg aca gat gag agc ctc agc      448
 Ala Met Val Leu Lys Arg Pro Glu Ile Leu Thr Asp Glu Ser Leu Ser
              30                  35                  40

 agc ttg gca gtc tca tgt ccc ctt acc tca ctt gac tct agc cgc agc      496
 Ser Leu Ala Val Ser Cys Pro Leu Thr Ser Leu Asp Ser Ser Arg Ser
          45                  50                  55

 ttc caa acc agt gcc att tca agg gac atc gac aca gca gcc aag ttc      544
 Phe Gln Thr Ser Ala Ile Ser Arg Asp Ile Asp Thr Ala Ala Lys Phe
      60                  65                  70

 att gga act ggg gct gtc aca gtt ggg gtg gct ggt ttt ggg gct ggg      592
 Ile Gly Thr Gly Ala Val Thr Val Gly Val Ala Gly Phe Gly Ala Gly
  75                  80                  85                  90

 att gga act gtg ttt ggg agc ctc atc att ggt tat gcc agg aac cct      640
 Ile Gly Thr Val Phe Gly Ser Leu Ile Ile Gly Tyr Ala Arg Asn Pro
                  95                 100                 105

 ttt ttg aaa caa cag ctt ttt tcc tac gcc att ttg ggc ttt gcc ctc      688
 Phe Leu Lys Gln Gln Leu Phe Ser Tyr Ala Ile Leu Gly Phe Ala Leu
             110                 115                 120

 tcg gag gcc atg ggg ctt ttt tgt tta aag gaa gcc ttt ttc atc ctt      736
 Ser Glu Ala Met Gly Leu Phe Cys Leu Lys Glu Ala Phe Phe Ile Leu
         125                 130                 135

 ttt gcc atg tga agg aaccgtttcc ccctcccata gttttcccgg gtttggttgg      791
 Phe Ala Met 
     140

 ccccgtgtgt tccttttcct aaacctcccc aggcaacctg gggaaagtgg ttggctcagg    851

 gtttgacaaa aaaaaaacaa ataaatactg tattaataag aaaaaaaaaa aaaaaaaa      909




      <210> 187
      <211> 3336
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (76)..(3282)

      <400> 187
 atggagaggc ttaagcatgt gttaactgcc actgggaaga agtcggcaat cacggaagct     60

 accggagggg ataat atg gtc tcc ggc gat gga cgc ccc aaa agc agg tca     111
                  Met Val Ser Gly Asp Gly Arg Pro Lys Ser Arg Ser
                    1               5                  10

 gtt tcg ggc ctc cga gct ggg tct ggc agt tgg aaa cgc gcg ctg cct      159
 Val Ser Gly Leu Arg Ala Gly Ser Gly Ser Trp Lys Arg Ala Leu Pro
          15                  20                  25

 agg cgc cga att cct tgc ttt tct cgc ctg gag tcg ctc ggc agg cgc      207
 Arg Arg Arg Ile Pro Cys Phe Ser Arg Leu Glu Ser Leu Gly Arg Arg
      30                  35                  40

 cca ggc cct cgg ggc tcg ggt tgt gct ccc ctc ggg gcc tgc ctg ctg      255
 Pro Gly Pro Arg Gly Ser Gly Cys Ala Pro Leu Gly Ala Cys Leu Leu
  45                  50                  55                  60

 ggc cgc cct ttg agc cta ggc cgc gga agc tgg ggc tcc cga tcc cca      303
 Gly Arg Pro Leu Ser Leu Gly Arg Gly Ser Trp Gly Ser Arg Ser Pro
                  65                  70                  75

 ccc tcc tgc gcg aca ccc gca ggg cgg gcc acc cca ccg ctg gcc ttg      351
 Pro Ser Cys Ala Thr Pro Ala Gly Arg Ala Thr Pro Pro Leu Ala Leu
              80                  85                  90

 acc cgc acc cct ctc tct ccg gtg gcc gct gcc tgc tgc cag cgg ctt      399
 Thr Arg Thr Pro Leu Ser Pro Val Ala Ala Ala Cys Cys Gln Arg Leu
          95                 100                 105

 cct ggc ccc cga tac gcc ttt gag tac ctt att gaa aca tta aat gac      447
 Pro Gly Pro Arg Tyr Ala Phe Glu Tyr Leu Ile Glu Thr Leu Asn Asp
     110                 115                 120

 agt tca cat aag aag ttc ttc gat gta tct aaa ctt ggc acc aag tat      495
 Ser Ser His Lys Lys Phe Phe Asp Val Ser Lys Leu Gly Thr Lys Tyr
 125                 130                 135                 140

 gat gtt ctg cct tac tca ata cgg gtc ttg ttg gaa gct gct gta cga      543
 Asp Val Leu Pro Tyr Ser Ile Arg Val Leu Leu Glu Ala Ala Val Arg
                 145                 150                 155

 aat tgt gat ggc ttt tta atg aag aag gaa gat gtt atg aac att tta      591
 Asn Cys Asp Gly Phe Leu Met Lys Lys Glu Asp Val Met Asn Ile Leu
             160                 165                 170

 gac tgg aaa acc aaa caa agc aat gtt gaa gtg ccc ttt ttc cct gcc      639
 Asp Trp Lys Thr Lys Gln Ser Asn Val Glu Val Pro Phe Phe Pro Ala
         175                 180                 185

 cgt gtt ctt ctt caa gat ttt act gga ata cca gca atg gtg gat ttt      687
 Arg Val Leu Leu Gln Asp Phe Thr Gly Ile Pro Ala Met Val Asp Phe
     190                 195                 200

 gct gct atg agg gag gca gtg aaa act ctt gga ggt gat cct gag aaa      735
 Ala Ala Met Arg Glu Ala Val Lys Thr Leu Gly Gly Asp Pro Glu Lys
 205                 210                 215                 220

 gtc cat cct gct tgt ccg aca gat ctt aca gtt gac cat tct tta caa      783
 Val His Pro Ala Cys Pro Thr Asp Leu Thr Val Asp His Ser Leu Gln
                 225                 230                 235

 att gac ttc agt aaa tgt gca ata cag aat gca cca aat cct gga ggt      831
 Ile Asp Phe Ser Lys Cys Ala Ile Gln Asn Ala Pro Asn Pro Gly Gly
             240                 245                 250

 ggt gac ctg cag aaa gca gga aag ctc tct cca ctt aaa gtg cag cct      879
 Gly Asp Leu Gln Lys Ala Gly Lys Leu Ser Pro Leu Lys Val Gln Pro
         255                 260                 265

 aag aag ctt ccc tgc aga ggc cag act acc tgc cga gga tct tgt gat      927
 Lys Lys Leu Pro Cys Arg Gly Gln Thr Thr Cys Arg Gly Ser Cys Asp
     270                 275                 280

 tct gga gaa cta ggc cga aac tca gga aca ttt tct tcg cag att gag      975
 Ser Gly Glu Leu Gly Arg Asn Ser Gly Thr Phe Ser Ser Gln Ile Glu
 285                 290                 295                 300

 aat aca ccc atc ctg tgt cct ttt cat ttg caa cca gtg cct gaa cct     1023
 Asn Thr Pro Ile Leu Cys Pro Phe His Leu Gln Pro Val Pro Glu Pro
                 305                 310                 315

 gaa aca gtg tta aaa aat caa gaa gta gaa ttc ggc aga aat cga gag     1071
 Glu Thr Val Leu Lys Asn Gln Glu Val Glu Phe Gly Arg Asn Arg Glu
             320                 325                 330

 agg ctt cag ttt ttt aag tgg agt tca aga gtt tta aag aat gtg gca     1119
 Arg Leu Gln Phe Phe Lys Trp Ser Ser Arg Val Leu Lys Asn Val Ala
         335                 340                 345

 gtg atc cct cct gga act gga atg gct cat caa ata aac tta gaa tat     1167
 Val Ile Pro Pro Gly Thr Gly Met Ala His Gln Ile Asn Leu Glu Tyr
     350                 355                 360

 ttg tca aga gtg gtt ttt gaa gaa aaa gac ctc ctc ttc cca gac agt     1215
 Leu Ser Arg Val Val Phe Glu Glu Lys Asp Leu Leu Phe Pro Asp Ser
 365                 370                 375                 380

 gta gtc ggc aca gat tca cac ata acg atg gtg aat ggt tta ggg att     1263
 Val Val Gly Thr Asp Ser His Ile Thr Met Val Asn Gly Leu Gly Ile
                 385                 390                 395

 ctg ggg tgg ggg gtt gga ggc att gaa aca gaa gca gtt atg ctt ggt     1311
 Leu Gly Trp Gly Val Gly Gly Ile Glu Thr Glu Ala Val Met Leu Gly
             400                 405                 410

 ctg cca gtt tct ctt act tta cca gag gtg gtt gga tgt gag tta act     1359
 Leu Pro Val Ser Leu Thr Leu Pro Glu Val Val Gly Cys Glu Leu Thr
         415                 420                 425

 ggg tca tca aac cct ttt gtt aca tcc ata gat gtt gtt ctt ggt att     1407
 Gly Ser Ser Asn Pro Phe Val Thr Ser Ile Asp Val Val Leu Gly Ile
     430                 435                 440

 aca aag cac ctc agg caa gta gga gtg gct gga aag ttt gtt gag ttt     1455
 Thr Lys His Leu Arg Gln Val Gly Val Ala Gly Lys Phe Val Glu Phe
 445                 450                 455                 460

 ttt gga agt gga gtt tca caa tta tct ata gtt gat cga act aca ata     1503
 Phe Gly Ser Gly Val Ser Gln Leu Ser Ile Val Asp Arg Thr Thr Ile
                 465                 470                 475

 gca aac atg tgt ccg gaa tat ggt gct atc ctc agc ttt ttc cct gtt     1551
 Ala Asn Met Cys Pro Glu Tyr Gly Ala Ile Leu Ser Phe Phe Pro Val
             480                 485                 490

 gac aat gtg aca tta aaa cat tta gaa cat aca ggt ttt agc aaa gcc     1599
 Asp Asn Val Thr Leu Lys His Leu Glu His Thr Gly Phe Ser Lys Ala
         495                 500                 505

 aaa ctc gaa tca atg gaa aca tac ctt aaa gct gtg aaa ttg ttt cga     1647
 Lys Leu Glu Ser Met Glu Thr Tyr Leu Lys Ala Val Lys Leu Phe Arg
     510                 515                 520

 aat gac cag aat tct tca gga gaa cct gaa tac tcc cag gtg atc cag     1695
 Asn Asp Gln Asn Ser Ser Gly Glu Pro Glu Tyr Ser Gln Val Ile Gln
 525                 530                 535                 540

 att aat ctg aat tca ata gtt cca tct gtt agt ggt cca aaa aga cct     1743
 Ile Asn Leu Asn Ser Ile Val Pro Ser Val Ser Gly Pro Lys Arg Pro
                 545                 550                 555

 cag gat aga gtt gct gtg aca gat atg aaa agc gat ttc cag gct tgc     1791
 Gln Asp Arg Val Ala Val Thr Asp Met Lys Ser Asp Phe Gln Ala Cys
             560                 565                 570

 tta aat gaa aag gtt gga ttt aaa ggc ttc caa att gca gct gaa aaa     1839
 Leu Asn Glu Lys Val Gly Phe Lys Gly Phe Gln Ile Ala Ala Glu Lys
         575                 580                 585

 caa aag gat att gtc tcc att cat tat gaa gga agt gaa tat aag ctg     1887
 Gln Lys Asp Ile Val Ser Ile His Tyr Glu Gly Ser Glu Tyr Lys Leu
     590                 595                 600

 tct cat gga tca gtg gtc att gct gca gtt atc agt tgt acc aat aat     1935
 Ser His Gly Ser Val Val Ile Ala Ala Val Ile Ser Cys Thr Asn Asn
 605                 610                 615                 620

 tgc aat cca tct gtc atg ctt gct gca ggt ctt ttg gct aaa aag gct     1983
 Cys Asn Pro Ser Val Met Leu Ala Ala Gly Leu Leu Ala Lys Lys Ala
                 625                 630                 635

 gtt gaa gct ggt ctg cgt gtt aaa cct tat ata aga aca agt tta tct     2031
 Val Glu Ala Gly Leu Arg Val Lys Pro Tyr Ile Arg Thr Ser Leu Ser
             640                 645                 650

 cca ggc agt ggg atg gtt aca cat tac ctc agt tca agt gga gta tta     2079
 Pro Gly Ser Gly Met Val Thr His Tyr Leu Ser Ser Ser Gly Val Leu
         655                 660                 665

 cca tat cta agt aag ctt gga ttt gaa atc gtt ggc tat gga tgt tca     2127
 Pro Tyr Leu Ser Lys Leu Gly Phe Glu Ile Val Gly Tyr Gly Cys Ser
     670                 675                 680

 act tgt gtg gga aat aca gca ccc tta tca gac gca gtt tta aat gca     2175
 Thr Cys Val Gly Asn Thr Ala Pro Leu Ser Asp Ala Val Leu Asn Ala
 685                 690                 695                 700

 gta aaa cag ggt gat ttg gtt acc tgt gga att tta tct gga aac aaa     2223
 Val Lys Gln Gly Asp Leu Val Thr Cys Gly Ile Leu Ser Gly Asn Lys
                 705                 710                 715

 aat ttt gaa ggt cgt ctt tgt gat tgt gtt cgt gcc aat tat ctt gcc     2271
 Asn Phe Glu Gly Arg Leu Cys Asp Cys Val Arg Ala Asn Tyr Leu Ala
             720                 725                 730

 tct cca ccc tta gtg gta gct tat gcc ata gca ggc aca gtg aat ata     2319
 Ser Pro Pro Leu Val Val Ala Tyr Ala Ile Ala Gly Thr Val Asn Ile
         735                 740                 745

 gat ttc cag aca gaa cct tta ggt act gac ccc acc ggc aag aac att     2367
 Asp Phe Gln Thr Glu Pro Leu Gly Thr Asp Pro Thr Gly Lys Asn Ile
     750                 755                 760

 tac ctg cat gat att tgg cct agt cga gaa gaa gtt cat cga gta gag     2415
 Tyr Leu His Asp Ile Trp Pro Ser Arg Glu Glu Val His Arg Val Glu
 765                 770                 775                 780

 gaa gaa cat gtt ata cta tcc atg ttt aaa gca tta aaa gat aaa ata     2463
 Glu Glu His Val Ile Leu Ser Met Phe Lys Ala Leu Lys Asp Lys Ile
                 785                 790                 795

 gaa atg ggg aat aaa cgg tgg aat tcc tta gaa gca ccg gat tca gtt     2511
 Glu Met Gly Asn Lys Arg Trp Asn Ser Leu Glu Ala Pro Asp Ser Val
             800                 805                 810

 ttg ttt cca tgg gac tta aag tct act tat atc aga tgc cct tca ttt     2559
 Leu Phe Pro Trp Asp Leu Lys Ser Thr Tyr Ile Arg Cys Pro Ser Phe
         815                 820                 825

 ttt gat aaa ctt acc aaa gag cca att gca ctc cag gct att gaa aat     2607
 Phe Asp Lys Leu Thr Lys Glu Pro Ile Ala Leu Gln Ala Ile Glu Asn
     830                 835                 840

 gcc cat gtc tta tta tat ttg gga gac tct gtc aca aca gat cat ata     2655
 Ala His Val Leu Leu Tyr Leu Gly Asp Ser Val Thr Thr Asp His Ile
 845                 850                 855                 860

 tca cct gca gga agt atc gct agg aat agt gct gcc gct aag tat ttg     2703
 Ser Pro Ala Gly Ser Ile Ala Arg Asn Ser Ala Ala Ala Lys Tyr Leu
                 865                 870                 875

 aca aac aga ggc ctt acc cct cgt gaa ttc aac tct tac gga gct cga     2751
 Thr Asn Arg Gly Leu Thr Pro Arg Glu Phe Asn Ser Tyr Gly Ala Arg
             880                 885                 890

 aga ggt aat gat gct gta atg aca aga ggc act ttt gca aat atc aag     2799
 Arg Gly Asn Asp Ala Val Met Thr Arg Gly Thr Phe Ala Asn Ile Lys
         895                 900                 905

 ctt ttt aat aag ttt att gga aaa cca gct cct aaa aca att cat ttt     2847
 Leu Phe Asn Lys Phe Ile Gly Lys Pro Ala Pro Lys Thr Ile His Phe
     910                 915                 920

 cca tca gga cag acg cta gat gta ttt gag gct gca gag ctg tac cag     2895
 Pro Ser Gly Gln Thr Leu Asp Val Phe Glu Ala Ala Glu Leu Tyr Gln
 925                 930                 935                 940

 aaa gaa ggt atc cca ctg att att tta gca gga aag aaa tat ggt tca     2943
 Lys Glu Gly Ile Pro Leu Ile Ile Leu Ala Gly Lys Lys Tyr Gly Ser
                 945                 950                 955

 gga aac tcc aga gac tgg gct gcc aaa gga ccg tat tta ctg ggt gtg     2991
 Gly Asn Ser Arg Asp Trp Ala Ala Lys Gly Pro Tyr Leu Leu Gly Val
             960                 965                 970

 aaa gct gtt ttg gct gaa agt tat gaa aaa ata cac aaa gat cat ttg     3039
 Lys Ala Val Leu Ala Glu Ser Tyr Glu Lys Ile His Lys Asp His Leu
         975                 980                 985

 att gga att ggc ata gct cca ctt cag ttc ctt cca gga gaa aat gca     3087
 Ile Gly Ile Gly Ile Ala Pro Leu Gln Phe Leu Pro Gly Glu Asn Ala
     990                 995                1000

 gat tcc ttg ggc ctc tcc ggt aga gaa aca ttt tct tta aca ttt cct     3135
 Asp Ser Leu Gly Leu Ser Gly Arg Glu Thr Phe Ser Leu Thr Phe Pro
1005                1010                1015                1020

 gaa gaa ctg tct cct gga att aca ttg aat ata cag aca agc act gga     3183
 Glu Glu Leu Ser Pro Gly Ile Thr Leu Asn Ile Gln Thr Ser Thr Gly
                1025                1030                1035

 aaa gta ttc agc gtg att gct tcg ttt gaa gat gat gtg gaa ata aca     3231
 Lys Val Phe Ser Val Ile Ala Ser Phe Glu Asp Asp Val Glu Ile Thr
            1040                1045                1050

 tta tac aaa cat gga gga tta tta aac ttt gtg gca cga aaa ttc tca     3279
 Leu Tyr Lys His Gly Gly Leu Leu Asn Phe Val Ala Arg Lys Phe Ser
        1055                1060                1065

 tag tatc tacttaccat agataccttt cataactggt aactgcaaag ccttttgtgc     3336
 






      <210> 188
      <211> 2097
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (447)..(1043)

      <400> 188
 tcagtttggc tgtttcttag gaggggtgct gagcctgaaa tcactagaca gttggtcagt     60

 atcaaaagat ggacaagaag cagaggagag cagggaaaaa tcaagccagc aggtctgtgg    120

 aaacgtgcat gagcttgccg caaagtctaa ctttcgggga ccttccaaaa atacacacag    180

 cttcagctcc actttcatct tccaaatctc gcacaagttg cttttagggc ctatcttaac    240

 caggagcatg caaaaaagga attctgtgat tccctggatg gttaccattc ttttgaatgc    300

 ggctccatag atcccctgac aggctcccac tatacctgtc gccgaagtcc cagactcctc    360

 accaatggct actatatttg gactgaagac agcttccttg cgacaaagat ggcaacataa    420

 ctctgaaccc atcccagacc agcgtt atg tat aag gag aac tta gtt agg ata     473
                              Met Tyr Lys Glu Asn Leu Val Arg Ile
                                1               5

 ttt aga aag aaa aag aga atc tgc cat tcc ttt tct tct ctc ttc aac      521
 Phe Arg Lys Lys Lys Arg Ile Cys His Ser Phe Ser Ser Leu Phe Asn
  10                  15                  20                  25

 ctc agt acc tcc aaa tct tgg ctg cat gga agt atc ttt ggt gac atc      569
 Leu Ser Thr Ser Lys Ser Trp Leu His Gly Ser Ile Phe Gly Asp Ile
                  30                  35                  40

 aac tct tct cca agt gaa gac aac tgg ttg aag ggg acc agg agg ttg      617
 Asn Ser Ser Pro Ser Glu Asp Asn Trp Leu Lys Gly Thr Arg Arg Leu
              45                  50                  55

 gac aca gac cat tgc aat gga aat gca gat gat tta gac tgt tct tct      665
 Asp Thr Asp His Cys Asn Gly Asn Ala Asp Asp Leu Asp Cys Ser Ser
          60                  65                  70

 ctg act gat gac tgg gag tca ggg aag atg aat gca gag tct gtg atc      713
 Leu Thr Asp Asp Trp Glu Ser Gly Lys Met Asn Ala Glu Ser Val Ile
      75                  80                  85

 acc tcc tct tcc agc cac atc ata tct cag cct cct gga gga aac tcc      761
 Thr Ser Ser Ser Ser His Ile Ile Ser Gln Pro Pro Gly Gly Asn Ser
  90                  95                 100                 105

 cat agc ttg tct ctt cag tcc cag ttg aca gct tct gaa cgt ttc caa      809
 His Ser Leu Ser Leu Gln Ser Gln Leu Thr Ala Ser Glu Arg Phe Gln
                 110                 115                 120

 gag aat agt tcg gat cat tca gaa acc agg ttg ttg caa gag gtc ttc      857
 Glu Asn Ser Ser Asp His Ser Glu Thr Arg Leu Leu Gln Glu Val Phe
             125                 130                 135

 ttt cag gca atc ctg ctt gct gtg tgc tta atc att tct gca tgt gca      905
 Phe Gln Ala Ile Leu Leu Ala Val Cys Leu Ile Ile Ser Ala Cys Ala
         140                 145                 150

 aga tgg ttt atg gga gaa ata tta gcc agt gtc ttc aca tgc tca ttg      953
 Arg Trp Phe Met Gly Glu Ile Leu Ala Ser Val Phe Thr Cys Ser Leu
     155                 160                 165

 atg ata act gta gct tat gtg aaa tca ttg ttt ctc agc ctt gcc agc     1001
 Met Ile Thr Val Ala Tyr Val Lys Ser Leu Phe Leu Ser Leu Ala Ser
 170                 175                 180                 185

 tat ttc aaa acc act gcc tgt gct cgg ttt gtc aaa att tga caaccat     1050
 Tyr Phe Lys Thr Thr Ala Cys Ala Arg Phe Val Lys Ile 
                 190                 195

 ttaggaatgc cttcgatgaa tgtcctccat ctgaatatct ggaaattgtc caacttgcag   1110

 tctacttgga atcaagtgtt ttattggaag ggagtaagcg agtaatggag aaaaagccat   1170

 tttagtttga ctatgtgatt ttaaaatgat ctcagttttt ccatcaaaat tataatatgc   1230

 tcatgaaaat aatattaatt tgccttccct ttgcaaacac cggcagttga aaggaaaagg   1290

 acggggaatg tgatggaaaa gagaccgcct ggaataaatg tccccctatg attctttaag   1350

 gcagtggttc tcgagcttga attttcatta ggaaattctg tgaggagctt gtaaccagat   1410

 ttctgggtct gccacatgca cctatctctt gctgaattgc tttaatagaa taatgagagc   1470

 aagtttgtct aactaatacc aacctgacaa cttgaataac aataaatgca atttgtacat   1530

 aaaatataat gctgcaaaag tttgtcattc acctcagtgg agtgacttga tattaggtgg   1590

 taaccgtaga tgatggttaa tatgaaaatg gacaggaaag aagcattttc tgaaagttat   1650

 attcttttga accacgttct aaaccaagtt tttaatcttc ttggggctcg taattacctt   1710

 tcactttaat gtcacttaaa gatataacac agaaaaatgc cttgagggca aaatataggc   1770

 aaaacaccaa tgcgctttca aatgcatgaa aatggtgcag ttgtaccctt gagccttgac   1830

 tcaagggctg tagatgttcc ctttccaccc cccacacttg gtgcgtgttc acaaagcaaa   1890

 tatggcctgt aattcaaatt tgttctatgt gatactctct gagtaaaaac tcatacatgc   1950

 agaaaattgt ctttgctcga aatggtaatg ccaaaatata actttatata taatttgcat   2010

 ttagtacatt tttggttaaa aaataaacta ataaataagt gaagtcatca gcaaaaaaaa   2070

 aaaaaaaaaa agttttgccc tatagtg                                       2097




      <210> 189
      <211> 2135
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (197)..(1081)

      <400> 189
 ggatgaagga acagaagata gaagcctcta gtttatgtct tgcttccggt agatccctgg     60

 tgataagggt acctgcacta ctggagtctt cctgctgaag ctggaacatc agctattccc    120

 atcttcttac atgcctccac tgtttgcaat tatacatatt gatacatgta tcaacatatg    180

 taactgttga tcaggt    atg ata cat tct act tct ctc tca ttt gtt tat     229
                      Met Ile His Ser Thr Ser Leu Ser Phe Val Tyr
                        1               5                  10

 gca ggt tct tcc agg ttg gaa aga gaa tat gct gga gag ctg tct ccc      277
 Ala Gly Ser Ser Arg Leu Glu Arg Glu Tyr Ala Gly Glu Leu Ser Pro
              15                  20                  25

 acg tgc att ttc cca agt ttc acc tgt gat tcc ctg gat ggt tac cat      325
 Thr Cys Ile Phe Pro Ser Phe Thr Cys Asp Ser Leu Asp Gly Tyr His
          30                  35                  40

 tct ttt gaa tgc ggc tcc ata gat ccc ctg aca ggc tcc cac tat acc      373
 Ser Phe Glu Cys Gly Ser Ile Asp Pro Leu Thr Gly Ser His Tyr Thr
      45                  50                  55

 tgt cgc cga agt ccc aga ctc ctc acc aat ggc tac tat att tgg act      421
 Cys Arg Arg Ser Pro Arg Leu Leu Thr Asn Gly Tyr Tyr Ile Trp Thr
  60                  65                  70                  75

 gaa gac agc ttc ctg tgc gac aaa gat ggc aac ata act ctg aac cca      469
 Glu Asp Ser Phe Leu Cys Asp Lys Asp Gly Asn Ile Thr Leu Asn Pro
                  80                  85                  90

 tcc cag acc agc gtt atg tat aag gag aac tta gtt agg ata ttt aga      517
 Ser Gln Thr Ser Val Met Tyr Lys Glu Asn Leu Val Arg Ile Phe Arg
              95                 100                 105

 aag aaa aag aga atc tgc cat tcc ttt tct tct ctc ttc aac ctc agt      565
 Lys Lys Lys Arg Ile Cys His Ser Phe Ser Ser Leu Phe Asn Leu Ser
         110                 115                 120

 acc tcc aaa tct tgg ctg cat gga agt atc ttt ggt gac atc aac tct      613
 Thr Ser Lys Ser Trp Leu His Gly Ser Ile Phe Gly Asp Ile Asn Ser
     125                 130                 135

 tct cca agt gaa gac aac tgg ttg aag ggg acc agg agg ttg gac aca      661
 Ser Pro Ser Glu Asp Asn Trp Leu Lys Gly Thr Arg Arg Leu Asp Thr
 140                 145                 150                 155

 gac cat tgc aat gga aat gca gat gat tta gac tgt tct tct ctg act      709
 Asp His Cys Asn Gly Asn Ala Asp Asp Leu Asp Cys Ser Ser Leu Thr
                 160                 165                 170

 gat gac tgg gag tca ggg aag atg aat gca gag tct gtg atc acc tcc      757
 Asp Asp Trp Glu Ser Gly Lys Met Asn Ala Glu Ser Val Ile Thr Ser
             175                 180                 185

 tct tcc agc cac atc ata tct cag cct cct gga gga aac tcc cat agc      805
 Ser Ser Ser His Ile Ile Ser Gln Pro Pro Gly Gly Asn Ser His Ser
         190                 195                 200

 ttg tct ctt cag tcc cag ttg aca gct tct gaa cgt ttc caa gag aat      853
 Leu Ser Leu Gln Ser Gln Leu Thr Ala Ser Glu Arg Phe Gln Glu Asn
     205                 210                 215

 agt tcg gat cat tca gaa acc agg ttg ttg caa gag gtc ttc ttt cag      901
 Ser Ser Asp His Ser Glu Thr Arg Leu Leu Gln Glu Val Phe Phe Gln
 220                 225                 230                 235

 gca atc ctg ctt gct gtg tgc tta atc att tct gca tgt gca aga tgg      949
 Ala Ile Leu Leu Ala Val Cys Leu Ile Ile Ser Ala Cys Ala Arg Trp
                 240                 245                 250

 ttt atg gga gaa ata tta gcc agt gtc ttc aca tgc tca ttg atg ata      997
 Phe Met Gly Glu Ile Leu Ala Ser Val Phe Thr Cys Ser Leu Met Ile
             255                 260                 265

 act gta gct tat gtg aaa tca ttg ttt ctc agc ctt gcc agc tat ttc     1045
 Thr Val Ala Tyr Val Lys Ser Leu Phe Leu Ser Leu Ala Ser Tyr Phe
         270                 275                 280

 aaa acc act gcc tgt gct cgg ttt gtc aaa att tga caac catttaggaa     1095
 Lys Thr Thr Ala Cys Ala Arg Phe Val Lys Ile 
     285                 290

 tgccttcgat gaatgtcctc catctgaata tctggaaatt gtccaacttg cagtctactt   1155

 ggaatcaagt gttttattgg aagggagtaa gcgagtaatg gagaaaaagc cattttagtt   1215

 tgactatgtg attttaaaat gatctcagtt tttccatcaa aattataata tgctcatgaa   1275

 aataatatta atttgccttc cctttgcaaa caccggcagt tgaaaggaaa aggacgggga   1335

 atgtgatgga aaagagaccg cctggaataa atgtccccct atgattcttt aaggcagtgg   1395

 ttctcgagct tgaattttca ttaggaaatt ctgtgaggag cttgtaacca gatttctggg   1455

 tctgccacat gcacctatct cttgctgaat tgctttaata gaataatgag agcaagtttg   1515

 tctaactaat accaacctga caacttgaat aacaataaat gcaatttgta cataaaatat   1575

 aatgctgcaa aagtttgtca ttcacctcag tggagtgact tgatattagg tggtaaccgt   1635

 agatgatggt taatatgaaa atggacagga aagaagcatt ttctgaaagt tatattcttt   1695

 tgaaccacgt tctaaaccaa gtttttaatc ttcttggggc tcgtaattac ctttcacttt   1755

 aatgtcactt aaagatataa cacagaaaaa tgccttgagg gcaaaatata ggcaaaacac   1815

 caatgcgctt tcaaatgcat gaaaatggtg cagttgtacc cttgagcctt gactcaaggg   1875

 ctgtagatgt tccctttcca ccccccacac ttggtgcgtg ttcacaaagc aaatatggcc   1935

 tgtaattcaa atttgttcta tgtgatactc tctgagtaaa aactcataca tgcagaaaat   1995

 tgtctttgct cgaaatggta atgccaaaat ataactttat atataatttg catttagtac   2055

 atttttggtt aaaaaataaa ctaataaata agtgaagtca tcagcaaaaa aaaaaaaaaa   2115

 aaaagttttg ccctatagtg                                               2135




      <210> 190
      <211> 2097
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (297)..(1043)

      <400> 190
 tcagtttggc tgtttcttag gaggggtgct gagcctgaaa tcactagaca gttggtcagt     60

 atcaaaagat ggacaagaag cagaggagag cagggaaaaa tcaagccagc aggtctgtgg    120

 aaacgtgcat gagcttgccg caaagtctaa ctttcgggga ccttccaaaa atacacacag    180

 cttcagctcc actttcatct tccaaatctc gcacaagttg cttttagggc ctatcttaac    240

 caggagcatg caaaaaagga attctgtgat tccctggatg gttaccattc ttttga        296                                                                 
 atg cgg ctc cat aga tcc cct gac agg ctc cca cta tac ctg tcg ccg      344
 Met Arg Leu His Arg Ser Pro Asp Arg Leu Pro Leu Tyr Leu Ser Pro
   1               5                  10                  15

 aag ccc aga ctc ctc acc aat ggc tac tat att tgg act gaa gac agc      392
 Lys Pro Arg Leu Leu Thr Asn Gly Tyr Tyr Ile Trp Thr Glu Asp Ser
              20                  25                  30

 ttc ctg tgc gac aaa gat ggc aac ata act ctg aac cca tcc cag acc      440
 Phe Leu Cys Asp Lys Asp Gly Asn Ile Thr Leu Asn Pro Ser Gln Thr
          35                  40                  45

 agc gtt atg tat aag gag aac tta gtt agg ata ttt aga aag aaa aag      488
 Ser Val Met Tyr Lys Glu Asn Leu Val Arg Ile Phe Arg Lys Lys Lys
      50                  55                  60

 aga atc tgc cat tcc ttt tct tct ctc ttc aac ctc agt acc tcc aaa      536
 Arg Ile Cys His Ser Phe Ser Ser Leu Phe Asn Leu Ser Thr Ser Lys
  65                  70                  75                  80

 tct tgg ctg cat gga agt atc ttt ggt gac atc aac tct tct cca agt      584
 Ser Trp Leu His Gly Ser Ile Phe Gly Asp Ile Asn Ser Ser Pro Ser
                  85                  90                  95

 gaa gac aac tgg ttg aag ggg acc agg agg ttg gac aca gac cat tgc      632
 Glu Asp Asn Trp Leu Lys Gly Thr Arg Arg Leu Asp Thr Asp His Cys
             100                 105                 110

 aat gga aat gca gat gat tta gac tgt tct tct ctg act gat gac tgg      680
 Asn Gly Asn Ala Asp Asp Leu Asp Cys Ser Ser Leu Thr Asp Asp Trp
         115                 120                 125

 gag tca ggg aag atg aat gca gag tct gtg atc acc tcc tct tcc agc      728
 Glu Ser Gly Lys Met Asn Ala Glu Ser Val Ile Thr Ser Ser Ser Ser
     130                 135                 140

 cac atc ata tct cag cct cct gga gga aac tcc cat agc ttg tct ctt      776
 His Ile Ile Ser Gln Pro Pro Gly Gly Asn Ser His Ser Leu Ser Leu
 145                 150                 155                 160

 cag tcc cag ttg aca gct tct gaa cgt ttc caa gag aat agt tcg gat      824
 Gln Ser Gln Leu Thr Ala Ser Glu Arg Phe Gln Glu Asn Ser Ser Asp
                 165                 170                 175

 cat tca gaa acc agg ttg ttg caa gag gtc ttc ttt cag gca atc ctg      872
 His Ser Glu Thr Arg Leu Leu Gln Glu Val Phe Phe Gln Ala Ile Leu
             180                 185                 190

 ctt gct gtg tgc tta atc att tct gca tgt gca aga tgg ttt atg gga      920
 Leu Ala Val Cys Leu Ile Ile Ser Ala Cys Ala Arg Trp Phe Met Gly
         195                 200                 205

 gaa ata tta gcc agt gtc ttc aca tgc tca ttg atg ata act gta gct      968
 Glu Ile Leu Ala Ser Val Phe Thr Cys Ser Leu Met Ile Thr Val Ala
     210                 215                 220

 tat gtg aaa tca ttg ttt ctc agc ctt gcc agc tat ttc aaa acc act     1016
 Tyr Val Lys Ser Leu Phe Leu Ser Leu Ala Ser Tyr Phe Lys Thr Thr
 225                 230                 235                 240

 gcc tgt gct cgg ttt gtc aaa att tga caacc atttaggaat gccttcgatg     1068
 Ala Cys Ala Arg Phe Val Lys Ile 
                 245

 aatgtcctcc atctgaatat ctggaaattg tccaacttgc agtctacttg gaatcaagtg   1128

 ttttattgga agggagtaag cgagtaatgg agaaaaagcc attttagttt gactatgtga   1188

 ttttaaaatg atctcagttt ttccatcaaa attataatat gctcatgaaa ataatattaa   1248

 tttgccttcc ctttgcaaac accggcagtt gaaaggaaaa ggacggggaa tgtgatggaa   1308

 aagagaccgc ctggaataaa tgtcccccta tgattcttta aggcagtggt tctcgagctt   1368

 gaattttcat taggaaattc tgtgaggagc ttgtaaccag atttctgggt ctgccacatg   1428

 cacctatctc ttgctgaatt gctttaatag aataatgaga gcaagtttgt ctaactaata   1488

 ccaacctgac aacttgaata acaataaatg caatttgtac ataaaatata atgctgcaaa   1548

 agtttgtcat tcacctcagt ggagtgactt gatattaggt ggtaaccgta gatgatggtt   1608

 aatatgaaaa tggacaggaa agaagcattt tctgaaagtt atattctttt gaaccacgtt   1668

 ctaaaccaag tttttaatct tcttggggct cgtaattacc tttcacttta atgtcactta   1728

 aagatataac acagaaaaat gccttgaggg caaaatatag gcaaaacacc aatgcgcttt   1788

 caaatgcatg aaaatggtgc agttgtaccc ttgagccttg actcaagggc tgtagatgtt   1848

 ccctttccac cccccacact tggtgcgtgt tcacaaagca aatatggcct gtaattcaaa   1908

 tttgttctat gtgatactct ctgagtaaaa actcatacat gcagaaaatt gtctttgctc   1968

 gaaatggtaa tgccaaaata taactttata tataatttgc atttagtaca tttttggtta   2028

 aaaaataaac taataaataa gtgaagtcat cagcaaaaaa aaaaaaaaaa aaagttttgc   2088

 cctatagtg                                                           2097




      <210> 191
      <211> 3389
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (617)..(1099)

      <220>
      <221> misc_feature
      <222> (1)...(3389)
      <223> n = a,t,c or g

      <400> 191
 atgacgacta aatcctatga tctgctgtct gcaagctgga gccatgggaa agacacagag     60

 ctatacttcc agttcaagtc tgaaggcctg agaaccagaa gaaccaatga tgggagttct    120

 agtctgaggg aaagagaaga tcaatgttca agggggtcag gatgtctagc atccctgacc    180

 cacatccctc aatgccagga cagtgtcatc atgacaacca aaaatgtctc cttatttcca    240

 gaatattctc taaaggggag tatcaccttt gtgacacaag aagaagagaa aataaaagat    300

 gtaatcgatg gctatctttt ggctgctgat gaagtgaggg aaagtggagg agagtcggcg    360

 ccgagatggg cggataaaag gagcgaccgc tcagcagcga gagggagagg cgagagtaag    420

 gcgcccagac accatgtgga caaggggagg agagaaatca gaggtggcgc gcgaaggctg    480

 agcgcccagg cagccagagc ccagatcgga agagccgagt ccgggcagag gggtccgcgg    540

 gctctggagg tgctggacgg gtgcgatccg agagcagacc ggggccctcg cgagcctctc    600

 ccggcccctg cccgcg    atg agc gag gcc agc cga ctg tgc tcc ggc tac     649
                      Met Ser Glu Ala Ser Arg Leu Cys Ser Gly Tyr
                        1               5                  10

 tac agc ctc aac cag agc ttc gtg gag ccc ttc cag tgc ccc cgg cgc      697
 Tyr Ser Leu Asn Gln Ser Phe Val Glu Pro Phe Gln Cys Pro Arg Arg
              15                  20                  25

 ggc gag ggg gca gcg ctc cag tat tgc tgc ggc ttc gcc gac ctc aag      745
 Gly Glu Gly Ala Ala Leu Gln Tyr Cys Cys Gly Phe Ala Asp Leu Lys
          30                  35                  40

 tac tgc tgc agc gag ccg ggc agc tac ttc ccc tac aag cac agc tac      793
 Tyr Cys Cys Ser Glu Pro Gly Ser Tyr Phe Pro Tyr Lys His Ser Tyr
      45                  50                  55

 atg tgg agc ctc agc att ggt gcc ttg att gga cta gga att gct gcc      841
 Met Trp Ser Leu Ser Ile Gly Ala Leu Ile Gly Leu Gly Ile Ala Ala
  60                  65                  70                  75

 ctt gtt tta ctc gcc ttt gtc atc agt gtc tgt gtc ctt tgc tat tta      889
 Leu Val Leu Leu Ala Phe Val Ile Ser Val Cys Val Leu Cys Tyr Leu
                  80                  85                  90

 ttt ctg tat acg aaa cct caa aga tta gac act ggc ctt aag ctt caa      937
 Phe Leu Tyr Thr Lys Pro Gln Arg Leu Asp Thr Gly Leu Lys Leu Gln
              95                 100                 105

 cac tta gag gct tct tcc act caa gaa ggc aag tca aat gga aaa acc      985
 His Leu Glu Ala Ser Ser Thr Gln Glu Gly Lys Ser Asn Gly Lys Thr
         110                 115                 120

 aaa gcc ctc aat tca aat gca gca tca aat gca aca aat gaa aca tac     1033
 Lys Ala Leu Asn Ser Asn Ala Ala Ser Asn Ala Thr Asn Glu Thr Tyr
     125                 130                 135

 tat gaa gct gat gat ata att caa gaa aaa aca atg gat gca aca caa     1081
 Tyr Glu Ala Asp Asp Ile Ile Gln Glu Lys Thr Met Asp Ala Thr Gln
 140                 145                 150                 155

 atc cac att gct tat taa ctaaaa attctgtgtt ttaaatgctt actggagaga     1135
 Ile His Ile Ala Tyr 
                 160

 tgggacaata aaaataaagc gtgcacttga aacggattgt aatattgctt ttcaaaaatt   1195

 cgtcactcac aaagcaagac acagctgcat ttttgatcat tcagttactt tattaaacgc   1255

 acattaaggt tttattggtt ttcctttgta taaatttatt tgctaattaa gatgtttctg   1315

 tatcacatga gattatgcta attattcagg agaaattaaa taatttatca ataacaagat   1375

 aagcagtcct atctcagtga agaacagtga gaagtttatg tcacattacc agcatttctc   1435

 aactttctga tacttacagg cagttattct tatgagatgg tactggatag gtaaatatca   1495

 agggaactgt cttaaaaact agaggtgact tgttcttaaa tctcttagaa gtcaacccac   1555

 atctttttag atttttctgg gcacaaacaa tatactcagt aacaaaaaaa tcacaatgta   1615

 taatctgtac aataaatatt ttgtttcaag agataagcat aacaaaaaat cctttgctga   1675

 tatatttcct aaataatctg tataatgaaa gctacaaaac aaatgagttc tctggtccca   1735

 cctaatgcta tcacattaat accacctaga aatctagaaa taaaactaat ttctgcaaat   1795

 tataattttt aaagattttt attcataagt gtgttttcta ttataacaca gacctggttt   1855

 tgtaacagaa ttcaacagaa aaaaaaaggg aattatttta agcagctcta ctgagcatat   1915

 ctactatgtc ctgtagtttt tgtagtcaga aactagcatt tcagacaaga tctggcacat   1975

 ttagggtggt atggccatag ccaaaaacta gcatttcaaa atgtgctgaa tacagcttct   2035

 ctggtctgat atataaaaaa gaatacctta tttttcttgg gcatgcaaag ctcagggtta   2095

 caaacttttc gtcattagcc tgtcaaaatt tctaccaagt actaaggtta tcttctagac   2155

 cagaattaag agaagtttct gtnatgatgg naatgttctt tctatatctn cactnnnnnn   2215

 nnnnnnnnnn nnnnnnnnnn nnnncngaac acntaagatg tggctaatnc aactgaaaaa   2275

 ataaaatttt tcatttattt aattaattta aataacccta tgtggctata ctggcaccat   2335

 agtgccagat cactattgca acaacctact gccaaagttg aacttcacat tcaaaaatac   2395

 aattttgcaa aggtttaaat actaaaattg cttaaagtat atgttaagtt tgaaaattaa   2455

 gacatttcca ttataaaaat gacattttac acggccataa aaacaaagaa ttttcactta   2515

 ttttttgtga aagtttataa agcttttatg ggtgcttctt gatctttgat acaactttga   2575

 ttttaaagta tcccagaaaa tttgctatct ttacagtaat ttaataatat taccatattg   2635

 tctcaggtga aaatctaggt tgagaaaaat ttagttaagg cactggcacc attctacttt   2695

 tgttgctcat ggccaaggac tataaatggc acaagaagca agaaacagac agagctagca   2755

 aaatgctcac tgccccaact cctcccaatt tgtgggaaag gcatagtggg gtcaggcatg   2815

 actggatgca tcatgggttg tgctatagaa gaggcacccc aattctctgc cactctacct   2875

 atttttagag gagttgggag gagatactga gatcagaaga ctggccttcg caactgggat   2935

 tattgtcaca ctggtataag aaacctactg ttcttgggca cccaatgtcc aggaagtttt   2995

 ggtctcagca ctaggatcag ctggagtcct tgaagcactc cctgctgagc tagcttatca   3055

 ctaggttacc tgaggtagaa ccacagggct catccagtgg accaactggt atgtttctct   3115

 gtaactctga agcagttgtg cttcacaggt taagccaaat tttaaaagca aggggcctta   3175

 ttaaattaca gcacattttg tacactgaaa aatattctaa atggtttatt cggacctaac   3235

 aaatattaaa atagtgatag aatttaagtc agtcaaaaat aacctaaaat acaattaaga   3295

 acaaaaccca tctcaaagta tgtacatgta catataactt tggggatgga tctaataaag   3355

 aatccagtag ctttatgtgt ttttactcgt gccg                               3389




      <210> 192
      <211> 3497
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (117)..(1301)

      <400> 192
 ccggcagact ccggagggta gagcgctgtg ccggttccgc tgccgctggc caggagcgcg     60

 gggacagttc ggggctgcgc cggaggccgg cccgccttcc cgggggttcc gttatc        116                                                                 
 atg tcg ctg agg cag cgc ctg gcc cag ctg gtt ggc cgt ctg cag gac      164
 Met Ser Leu Arg Gln Arg Leu Ala Gln Leu Val Gly Arg Leu Gln Asp
   1               5                  10                  15

 ccg cag aaa gtg gcc cgt ttc cag cgg cgc aat cag tgc ccg gcc aag      212
 Pro Gln Lys Val Ala Arg Phe Gln Arg Arg Asn Gln Cys Pro Ala Lys
              20                  25                  30

 ccg gac ggc ggc ggc gcc ccc aac ggc gtg cgg aac ggg ctg gcg gcc      260
 Pro Asp Gly Gly Gly Ala Pro Asn Gly Val Arg Asn Gly Leu Ala Ala
          35                  40                  45

 gag ctg ggc ccg gcc tcg ccg cgg cgc gcg ggc gct ctg cgc cgc aac      308
 Glu Leu Gly Pro Ala Ser Pro Arg Arg Ala Gly Ala Leu Arg Arg Asn
      50                  55                  60

 tcg ctg acg ggc gag gag ggc cag ctg gcc cgc gtg agc aac tgg ccg      356
 Ser Leu Thr Gly Glu Glu Gly Gln Leu Ala Arg Val Ser Asn Trp Pro
  65                  70                  75                  80

 ctc tac tgc ctg ttc tgc ttc ggc acg gag ctg ggc aac gaa ctc ttc      404
 Leu Tyr Cys Leu Phe Cys Phe Gly Thr Glu Leu Gly Asn Glu Leu Phe
                  85                  90                  95

 tac atc ctg ttc ttc ccc ttc tgg atc tgg aac ctg gac cct ctg gtg      452
 Tyr Ile Leu Phe Phe Pro Phe Trp Ile Trp Asn Leu Asp Pro Leu Val
             100                 105                 110

 ggc cgg agg ctc gtg gtc atc tgg gtg ctg gtc atg tac ctg ggc cag      500
 Gly Arg Arg Leu Val Val Ile Trp Val Leu Val Met Tyr Leu Gly Gln
         115                 120                 125

 tgc acc aag gac atc atc cgc tgg ccg agg ccc gcc tcg ccg ccc gtg      548
 Cys Thr Lys Asp Ile Ile Arg Trp Pro Arg Pro Ala Ser Pro Pro Val
     130                 135                 140

 gtc aag ttg gag gtc ttc tac aac tct gag tac agc atg ccc tcc acc      596
 Val Lys Leu Glu Val Phe Tyr Asn Ser Glu Tyr Ser Met Pro Ser Thr
 145                 150                 155                 160

 cat gcc atg tcc ggc acc gcc atc ccc att tct atg gtc ctc ctc acc      644
 His Ala Met Ser Gly Thr Ala Ile Pro Ile Ser Met Val Leu Leu Thr
                 165                 170                 175

 tat ggc cgc tgg cag tac cct ctt ata tat gga ctg att ctt att ccc      692
 Tyr Gly Arg Trp Gln Tyr Pro Leu Ile Tyr Gly Leu Ile Leu Ile Pro
             180                 185                 190

 tgc tgg tgt tct cta gtt tgc cta agt aga att tac atg gga atg cac      740
 Cys Trp Cys Ser Leu Val Cys Leu Ser Arg Ile Tyr Met Gly Met His
         195                 200                 205

 tct att ctg gat att att gct gga ttc cta tat acc att tta atc tta      788
 Ser Ile Leu Asp Ile Ile Ala Gly Phe Leu Tyr Thr Ile Leu Ile Leu
     210                 215                 220

 gct gtc ttc tat cca ttt gtg gac ctg att gac aac ttc aac caa act      836
 Ala Val Phe Tyr Pro Phe Val Asp Leu Ile Asp Asn Phe Asn Gln Thr
 225                 230                 235                 240

 cac aaa tat gct cca ttc atc atc atc ggg ctt cat tta gct ttg ggg      884
 His Lys Tyr Ala Pro Phe Ile Ile Ile Gly Leu His Leu Ala Leu Gly
                 245                 250                 255

 atc ttt tct ttc act ctt gac acc tgg agc aca tcc cga gga gac aca      932
 Ile Phe Ser Phe Thr Leu Asp Thr Trp Ser Thr Ser Arg Gly Asp Thr
             260                 265                 270

 gcc gag ata cta gga agt ggt gct gga att gca tgt gga tct cat gtt      980
 Ala Glu Ile Leu Gly Ser Gly Ala Gly Ile Ala Cys Gly Ser His Val
         275                 280                 285

 act tat aac atg ggt cta gta tta gat cct tct cta gat aca tta cct     1028
 Thr Tyr Asn Met Gly Leu Val Leu Asp Pro Ser Leu Asp Thr Leu Pro
     290                 295                 300

 tta gct ggg ccc ccc att act gtg act ctg ttt gga aaa gcc ata ttg     1076
 Leu Ala Gly Pro Pro Ile Thr Val Thr Leu Phe Gly Lys Ala Ile Leu
 305                 310                 315                 320

 cgg atc ctc ata ggg atg gta ttt gta cta ata atc aga gat gta atg     1124
 Arg Ile Leu Ile Gly Met Val Phe Val Leu Ile Ile Arg Asp Val Met
                 325                 330                 335

 aaa aag atc acc att cct tta gcc tgc aaa atc ttc aat ata ccg tgt     1172
 Lys Lys Ile Thr Ile Pro Leu Ala Cys Lys Ile Phe Asn Ile Pro Cys
             340                 345                 350

 gat gat att cga aaa gca aga cag cac atg gaa gtt gaa ctt cct tat     1220
 Asp Asp Ile Arg Lys Ala Arg Gln His Met Glu Val Glu Leu Pro Tyr
         355                 360                 365

 cgg tat att acc tat gga atg gtt ggt ttc tcc atc aca ttt ttt gtt     1268
 Arg Tyr Ile Thr Tyr Gly Met Val Gly Phe Ser Ile Thr Phe Phe Val
     370                 375                 380

 cct tac ata ttt ttc ttt att ggt atc tct tga tggagaag tattgtttat     1319
 Pro Tyr Ile Phe Phe Phe Ile Gly Ile Ser 
 385                 390

 gataagaaag gagggtatca gttactgata cccaaaaata tattccaggt aaagccaggt   1379

 cagaattagg cttttgcagg aatttaactt aaataattat ttaagtaaat tcataagagt   1439

 cagtgcattt tatcattgca catccagata ctgttttagg tgagctgagc tatttcgtta   1499

 ctgagaaaat gataagtatc catttagaat gttcatgtaa tgtttggaga gttttgtatt   1559

 atggattcaa cttatatata atatatataa ggtacataat atgcaattat atatctgata   1619

 tatattatat ataaaataat atacctaagt gtttttttaa actatgggag tgtattataa   1679

 aatcaataat aatatgcaaa cagttgtgcc tgtgtatttg aactacatac aggtatgttg   1739

 ttattaacag atatatttaa catttattta ctatgggagc catttcctaa ttgaattgcg   1799

 taattactag accagaatgc atatgctact atacattgat ttactgcctg tttttacact   1859

 gccattacct ttcatgttat ccatgatgtt gaacatggga ggcattttta atggaccaaa   1919

 tttttagaaa aattagtttt tggatttttt tttaagttct gtatactgtt ttgaatgaac   1979

 tttatttgca gctattctgg atgtcagttt aataattcag gtactgaatt ttattgcttg   2039

 ctaattgtgc ctttccgttg ctaaattaag aaatgctatg tgtactgtga tgtaaaaata   2099

 agacattaac tttatcttaa gttacatata atcaagcaaa tattttaaaa aatgtatgtc   2159

 agggtgacag gcataaaagt aaattaccct taactcttta gcctttattt agaaagaaat   2219

 gtggaatggg ctaaactttc tcaccaattt attagaaagc taaatggata aatacttccc   2279

 tttttgtaga tatttttctg tgcattgtaa gttataggag caggacatat tttttgtaca   2339

 ttgtcttgat tgtttatact gcaggtaggt atttccagtg aatggaaacg ttgaaattta   2399

 tagatgggac aatgcacata cttcatatgt aaacaaagca tttttctaaa taatttggaa   2459

 aggattggat ttagcaccgt taacttttaa tacccattta ttggctattt aaggtaaatt   2519

 ataaaaccta aaattagtat cagtatttta gatcctatta ttttttcaac tttctattat   2579

 tttcacagtg gaaaatttgc gtatagtatt aaactattct tttttctgtc tacctttata   2639

 ttttgaagtg tggttgtact tacgttaata gtaagtgtat ttgtagaaag tttttcataa   2699

 agaagagatt aactttccat ataaataaat accaggtatg aaattactga ttttagtgca   2759

 atatctgtat gattatccag aactatcact tcagatgttt ctattttggg caccataact   2819

 atttgagctc atatttttat aattctgatt gagaatttag gggcatggta atttttacca   2879

 aaactgaagc tggtaatttt aagtaaagca actaaattta ccctttactt attagttaaa   2939

 aggaaaccaa ggcatgtagg aaaatattgg tacgttggaa aatgtgaaaa gagctttact   2999

 ttcaaaatgt atgtttaatg aattgaattt tagggaccgt ttcccataat ttgggcctat   3059

 gctatcctgt tgatttttat gtctagctta aaaggtattt gaaaatgttc catttgtgtt   3119

 ttattatttt ctgtcctatg acagttctat gctaaatgta ttttaaaata aaagccaaat   3179

 tgaagattac aacacaaccc acaccccaac caccccccgc caaacgccgg cccacgaccg   3239

 ccacccaccg aacgacgcac acaacccagc cacatacacc aaccaccaca ccaaaaacaa   3299

 aacgcggcgc gccccaagac cactcccgcc gagcacacca ctccgccccc ctctcatacc   3359

 cagcgcgacc ccacgaccct ataaccaaca caccccggcc cgcccacacc gcacccaaca   3419

 cgacccccgc accaaaaaca cccccgcggc gaaccgcgcc cccccaccaa gccgccagat   3479

 aacccgacgg gagccccg                                                 3497




      <210> 193
      <211> 1943
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (235)..(1245)

      <220>
      <221> misc_feature
      <222> (1)...(1943)
      <223> n = a,t,c or g

      <400> 193
 agagaccaca gaaaccttaa ggggctaagg gttagcgatg gcctcgggtg tgctgtgtat     60

 gcatatgctg ccggagtagc gggctgggcc gaggtacctg cgactctcgg tgacaatcgt    120

 ctgcagtgat gtgctgatcg ccgtcagcca cctggnctat ggactgagtg tcacattcgt    180

 caggtaccac tctaggcctc gcacatctcg ataatacctc gaaggctcag ttat  atg     237
                                                              Met
                                                                1

 aga tat gtc cgg cta act ctc agt ggt ata cac cct agg cct att aca      285
 Arg Tyr Val Arg Leu Thr Leu Ser Gly Ile His Pro Arg Pro Ile Thr
               5                  10                  15

 ggg tcg ccg tca ccg ctg aag gag tcc ttc ggc ggc tgt tgt gtc agt      333
 Gly Ser Pro Ser Pro Leu Lys Glu Ser Phe Gly Gly Cys Cys Val Ser
          20                  25                  30

 ggc ctg atc gcg atg ggg aca aag gcg caa gtc gag agg aaa ctg ttg      381
 Gly Leu Ile Ala Met Gly Thr Lys Ala Gln Val Glu Arg Lys Leu Leu
      35                  40                  45

 tgc ctc ttc ata ttg gcg atc ctg ttg tgc tcc ctg gca ttg ggc agt      429
 Cys Leu Phe Ile Leu Ala Ile Leu Leu Cys Ser Leu Ala Leu Gly Ser
  50                  55                  60                  65

 gtt aca gtg cac tct tct gaa cct gaa gtc aga att cct gag aat aat      477
 Val Thr Val His Ser Ser Glu Pro Glu Val Arg Ile Pro Glu Asn Asn
                  70                  75                  80

 cct gtg aag ttg tcc tgt gcc tac tcg ggc ttt tct tct ccc cgt gtg      525
 Pro Val Lys Leu Ser Cys Ala Tyr Ser Gly Phe Ser Ser Pro Arg Val
              85                  90                  95

 gag tgg aag ttt gac caa gga gac acc acc aga ctc gtt tgc tat aat      573
 Glu Trp Lys Phe Asp Gln Gly Asp Thr Thr Arg Leu Val Cys Tyr Asn
         100                 105                 110

 aac aag atc aca gct tcc tat gag gac cgg gtg acc ttc ttg cca act      621
 Asn Lys Ile Thr Ala Ser Tyr Glu Asp Arg Val Thr Phe Leu Pro Thr
     115                 120                 125

 ggt atc acc ttc aag tcc gtg aca cgg gaa gac act ggg aca tac act      669
 Gly Ile Thr Phe Lys Ser Val Thr Arg Glu Asp Thr Gly Thr Tyr Thr
 130                 135                 140                 145

 tgt atg gtc tct gag gaa ggc ggc aac agc tat ggg gag gtc aag gtc      717
 Cys Met Val Ser Glu Glu Gly Gly Asn Ser Tyr Gly Glu Val Lys Val
                 150                 155                 160

 aag ctc atc gtg ctt gtg cct cca tcc aag cct aca gtt aac atc ccc      765
 Lys Leu Ile Val Leu Val Pro Pro Ser Lys Pro Thr Val Asn Ile Pro
             165                 170                 175

 tcc tct gcc acc att ggg aac cgg gca gtg ctg aca tgc tca gaa caa      813
 Ser Ser Ala Thr Ile Gly Asn Arg Ala Val Leu Thr Cys Ser Glu Gln
         180                 185                 190

 gat ggt tcc cca cct tct gaa tac acc tgg ttc aaa gat ggg ata gtg      861
 Asp Gly Ser Pro Pro Ser Glu Tyr Thr Trp Phe Lys Asp Gly Ile Val
     195                 200                 205

 atg cct acg aat ccc aaa agc acc cgt gcc ttc agc aac tct tcc tat      909
 Met Pro Thr Asn Pro Lys Ser Thr Arg Ala Phe Ser Asn Ser Ser Tyr
 210                 215                 220                 225

 gtc ctg aat ccc aca aca gga gag ctg gtc ttt gat ccc ctg tca gcc      957
 Val Leu Asn Pro Thr Thr Gly Glu Leu Val Phe Asp Pro Leu Ser Ala
                 230                 235                 240

 tct gat act gga gaa tac agc tgt gag gca cgg aat ggg tat ggg aca     1005
 Ser Asp Thr Gly Glu Tyr Ser Cys Glu Ala Arg Asn Gly Tyr Gly Thr
             245                 250                 255

 ccc atg act tca aat gct gtg cgc atg gaa gct gtg gag cgg aat gtg     1053
 Pro Met Thr Ser Asn Ala Val Arg Met Glu Ala Val Glu Arg Asn Val
         260                 265                 270

 ggg gtc atc gtg gca gcc gtc ctt gta acc ctg att ctc ctg gga atc     1101
 Gly Val Ile Val Ala Ala Val Leu Val Thr Leu Ile Leu Leu Gly Ile
     275                 280                 285

 ttg gtt ttt ggc atc tgg ttt gcc tat agc cga ggc cac ttt gac aga     1149
 Leu Val Phe Gly Ile Trp Phe Ala Tyr Ser Arg Gly His Phe Asp Arg
 290                 295                 300                 305

 aca aag aaa ggg act tcg agt aag aag gtg att tac agc cag cct agt     1197
 Thr Lys Lys Gly Thr Ser Ser Lys Lys Val Ile Tyr Ser Gln Pro Ser
                 310                 315                 320

 gcc cga agt gaa gga gaa ttc aaa cag acc tcg tca ttc ctg gtg tga     1245
 Ala Arg Ser Glu Gly Glu Phe Lys Gln Thr Ser Ser Phe Leu Val 
             325                 330                 335

 gcctggtcgg ctcaccgcct atcatctgca tttgccttac tcaggtgcta ccggactctg   1305

 gcccctgatg tctgtagttt cacaggatgc cttatttgtc ttctacaccc cacagggccc   1365

 cctacttctt cggatgtgtt tttaataatg tcagctatgt gccccatcct ccttcatgcc   1425

 ctccctccct ttcctaccac tgctgagtgg cctggaactt gtttaaagtg tttattcccc   1485

 atttctttga gggatcagga aggaatcctg ggtatgccat tgacttccct tctaagtaga   1545

 cagcaaaaat ggcgggggtc gcaggaatct gcactcaact gcccacctgg ctggcaggga   1605

 tctttgaata ggtatcttga gcttggttct gggctctttc cttgtgtact gacgaccagg   1665

 gccagctgtt ctagagcggg aattagaggc tagagcggct gaaatggttg tttggtgatg   1725

 acactggggt ccttccatct ctggggccca ctctcttctg tcttcccatg ggaagtgcca   1785

 ctgggatccc tctgccctgt cctcctgaat acaagctgac tgacattgac tgtgtctgtg   1845

 gaaaatggga gctcttgttg tggagagcat agtaaatttt cagagaactt gaagccaaaa   1905

 ggatttaaaa ccgctgctct aaagaaaaga aaactgga                           1943




      <210> 194
      <211> 1002
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (401)..(814)

      <400> 194
 gactactagt ccagcgcggt ggaattcgtc gggaagggta tcaaggaata acaccctatt     60

 gtgggcttgc ggagaatggg ggacttcaag gcgtgtcagt ttcaggaggg tgagggcagg    120

 agcgtgggtg gagtcagcag gtccccatga tggccctcac tgagagcttc gcccttgtct    180

 cctacaagct ctgactccat tcccagtggg cacccagcac ctccaacccc tccacagccc    240

 ccaacccagc ctctgtcgga ggcgaattct cagagtgagg gttccctgtc acttgagaga    300

 aggttccctg tgacgtgacc ttgggggacg tcattgccct ttctgtcccc acccaccccc    360

 tcggcagttc tgttggccag gactttggcc tagacaaagg  atg ggg gtt gtg gct     415
                                              Met Gly Val Val Ala
                                                1               5

 gtg gag cgg aag tgg gtc tca acc act ata aag cct ctc tgt gcc cgt      463
 Val Glu Arg Lys Trp Val Ser Thr Thr Ile Lys Pro Leu Cys Ala Arg
                  10                  15                  20

 ccg gag ctg gtg agg aca gcc tgc cag agt ctg gtc tct gac act atg      511
 Pro Glu Leu Val Arg Thr Ala Cys Gln Ser Leu Val Ser Asp Thr Met
              25                  30                  35

 ggc aca cga ctc ctc cca gct ctg ttt ctt gtc ctc ctg gta ttg gga      559
 Gly Thr Arg Leu Leu Pro Ala Leu Phe Leu Val Leu Leu Val Leu Gly
          40                  45                  50

 ttt gag gtc cag ggg acc caa cag ccc cag caa gat gag atg cct agc      607
 Phe Glu Val Gln Gly Thr Gln Gln Pro Gln Gln Asp Glu Met Pro Ser
      55                  60                  65

 ccg acc ttc ctc acc cag gtg aag gaa tct ctc tcc agt tac tgg gag      655
 Pro Thr Phe Leu Thr Gln Val Lys Glu Ser Leu Ser Ser Tyr Trp Glu
  70                  75                  80                  85

 tca gca aag aca gcc gcc cag aac ctg tac gag aag aca tac ctg ccc      703
 Ser Ala Lys Thr Ala Ala Gln Asn Leu Tyr Glu Lys Thr Tyr Leu Pro
                  90                  95                 100

 gct gta gat gag aaa ctc agg gac ttg tac agc aaa agc aca gca gcc      751
 Ala Val Asp Glu Lys Leu Arg Asp Leu Tyr Ser Lys Ser Thr Ala Ala
             105                 110                 115

 atg agc act tac aca ggc att ttt act gac caa gtt ctt tct gtg ctg      799
 Met Ser Thr Tyr Thr Gly Ile Phe Thr Asp Gln Val Leu Ser Val Leu
         120                 125                 130

 aag gga gag gag taa cagccagacc ccccatcagt ggacaagggg agagtcccct      854
 Lys Gly Glu Glu 
     135

 actcccctga tcccccaggt tcagactgag ctcccccttc ccagtagctc ttgcatcctc    914

 ctcccaactc tagcctgaat tcttttcaat aaaaaataca attcaagttg caaaaaaaaa    974

 aaaaaaaaaa accgcggccg caagctta                                      1002




      <210> 195
      <211> 976
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (84)..(710)

      <400> 195
 gccgctccgg ctgcaccgcg ctcgctccga gtttcaggct cgtgctaagc tagcgccgtc     60

 gtcgtctccc ttcagtcgcc atc    atg att atc tac cgg gac ctc atc agc     110
                              Met Ile Ile Tyr Arg Asp Leu Ile Ser
                                1               5

 cac gat gag atg ttc tcc gac atc tac aag atc cgg gag atc gcg gac      158
 His Asp Glu Met Phe Ser Asp Ile Tyr Lys Ile Arg Glu Ile Ala Asp
  10                  15                  20                  25

 ggg ttg tgc ctg gag gtg gag ggg aag atg gtc agt agg aca gaa ggt      206
 Gly Leu Cys Leu Glu Val Glu Gly Lys Met Val Ser Arg Thr Glu Gly
                  30                  35                  40

 aac att gat gac tcg ctc att ggt gga aat gcc tcc gct gaa ggc ccc      254
 Asn Ile Asp Asp Ser Leu Ile Gly Gly Asn Ala Ser Ala Glu Gly Pro
              45                  50                  55

 gag ggc gaa ggt acc gaa agc aca gta atc act ggt gtc gat att gtc      302
 Glu Gly Glu Gly Thr Glu Ser Thr Val Ile Thr Gly Val Asp Ile Val
          60                  65                  70

 atg aac cat cac ctg cag gaa aca agt ttc aca aaa gaa gcc tac aag      350
 Met Asn His His Leu Gln Glu Thr Ser Phe Thr Lys Glu Ala Tyr Lys
      75                  80                  85

 aag tac atc aaa gat tac atg aaa tca atc aaa ggg aaa ctt gaa gaa      398
 Lys Tyr Ile Lys Asp Tyr Met Lys Ser Ile Lys Gly Lys Leu Glu Glu
  90                  95                 100                 105

 cag aga cca gaa aga gta aaa cct ttt atg aca ggg gct gca gaa caa      446
 Gln Arg Pro Glu Arg Val Lys Pro Phe Met Thr Gly Ala Ala Glu Gln
                 110                 115                 120

 atc aag cac atc ctt gct aat ttc aaa aac tac cag ttc ttt att ggt      494
 Ile Lys His Ile Leu Ala Asn Phe Lys Asn Tyr Gln Phe Phe Ile Gly
             125                 130                 135

 gaa aac atg aat cca gat ggc atg gtt gct cta ttg gac tac cgt gag      542
 Glu Asn Met Asn Pro Asp Gly Met Val Ala Leu Leu Asp Tyr Arg Glu
         140                 145                 150

 gga tgg tgt gac ccc ata tat gat tcc tct tta cgg atg gtt aga aca      590
 Gly Trp Cys Asp Pro Ile Tyr Asp Ser Ser Leu Arg Met Val Arg Thr
     155                 160                 165

 tgg aca agc tgt tca cac atg tgg cac tta ttt ggg ctc cta tca cct      638
 Trp Thr Ser Cys Ser His Met Trp His Leu Phe Gly Leu Leu Ser Pro
 170                 175                 180                 185

 gtc atc ata ctg gtt ctg ctt gtc atc cac acc aac aca gga ctt aga      686
 Val Ile Ile Leu Val Leu Leu Val Ile His Thr Asn Thr Gly Leu Arg
                 190                 195                 200

 cca cat ggg act gat gtc atc tga gctctgcttt aatttgactg tgcattattg     740
 Pro His Gly Thr Asp Val Ile 
             205

 gcactggcgg ctggtctacg aaacactggc tgttgttgcc tcaccttact ggtttactcc    800

 aacacaaaag agggcgtcaa ataccggagg gcacgatacg tccagttgtg acagggccca    860

 agacaataaa acacgcggca ccacgggcag cgtgtcggca ccctgctgga tggcacacga    920

 cgtcatgtgt tcgctccggc gaccttcaac cgagcgcccc ctcgcacaac gtctaa        976




      <210> 196
      <211> 2568
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (76)..(2514)

      <400> 196
 ctcggggcga ttatttcggc cgagccttga cgccgttttt gacggccgat aacgaggctt     60

 ttcaccgagt caggg atg gga gcg gga ccc cgc ggg atg gtt ttc tca tgg     111
                  Met Gly Ala Gly Pro Arg Gly Met Val Phe Ser Trp
                    1               5                  10

 gtg ccc aga gta cgc gac atc ctc atc gtc tac agc ccg gat gcc gag      159
 Val Pro Arg Val Arg Asp Ile Leu Ile Val Tyr Ser Pro Asp Ala Glu
          15                  20                  25

 gaa tgg tgc cag tac ctg cag acc ctg ttc ctg tcc agt cgg cag gtc      207
 Glu Trp Cys Gln Tyr Leu Gln Thr Leu Phe Leu Ser Ser Arg Gln Val
      30                  35                  40

 cgc agc cag aag ata ctg act cac agg ctg ggc ccc gag gcc tcc ttc      255
 Arg Ser Gln Lys Ile Leu Thr His Arg Leu Gly Pro Glu Ala Ser Phe
  45                  50                  55                  60

 tcg gca gag gac cta agc ctt ttc ctc agc acc cgc tgt gtc gtg gtg      303
 Ser Ala Glu Asp Leu Ser Leu Phe Leu Ser Thr Arg Cys Val Val Val
                  65                  70                  75

 ctg ctg tcc gcg gag ctg gtg cag cac ttc cac aag ccc tcc ttg ctg      351
 Leu Leu Ser Ala Glu Leu Val Gln His Phe His Lys Pro Ser Leu Leu
              80                  85                  90

 ccc ctg ctg cag aga gct ttc cat cct ccg cac cgc gtg gtc agg ctg      399
 Pro Leu Leu Gln Arg Ala Phe His Pro Pro His Arg Val Val Arg Leu
          95                 100                 105

 ctc tgc ggc gtg cgg gac agc gag gag ttc cta gac ttc ttt cca gat      447
 Leu Cys Gly Val Arg Asp Ser Glu Glu Phe Leu Asp Phe Phe Pro Asp
     110                 115                 120

 tgg gcc cat tgg cag gag ctc acc tgt gac gat gag cca gag acc tac      495
 Trp Ala His Trp Gln Glu Leu Thr Cys Asp Asp Glu Pro Glu Thr Tyr
 125                 130                 135                 140

 gtg gca gct gtg aaa aaa gcc att tcc gaa gat tct ggc tgt gac tca      543
 Val Ala Ala Val Lys Lys Ala Ile Ser Glu Asp Ser Gly Cys Asp Ser
                 145                 150                 155

 gtc act gac act gag cct gag gac gag aag gtt gtt tcc tac tcg aag      591
 Val Thr Asp Thr Glu Pro Glu Asp Glu Lys Val Val Ser Tyr Ser Lys
             160                 165                 170

 cag cag aac ctg ccg acg gtg act tca cct ggg aac ctg atg gtg gtg      639
 Gln Gln Asn Leu Pro Thr Val Thr Ser Pro Gly Asn Leu Met Val Val
         175                 180                 185

 cag ccg gac cgc att cgc tgt ggg gca gaa acc act gtc tat gtt att      687
 Gln Pro Asp Arg Ile Arg Cys Gly Ala Glu Thr Thr Val Tyr Val Ile
     190                 195                 200

 gtg aga tgt aag ctg gat gac agg gtg gcg aca gaa gca gag ttt tct      735
 Val Arg Cys Lys Leu Asp Asp Arg Val Ala Thr Glu Ala Glu Phe Ser
 205                 210                 215                 220

 cct gag gat tct ccc tct gta agg atg gaa gcc aag gtg gag aat gag      783
 Pro Glu Asp Ser Pro Ser Val Arg Met Glu Ala Lys Val Glu Asn Glu
                 225                 230                 235

 tac acc att tca gtg aag gct ccc aac ctt tca tct ggg aac gtt tct      831
 Tyr Thr Ile Ser Val Lys Ala Pro Asn Leu Ser Ser Gly Asn Val Ser
             240                 245                 250

 ctg aag ata tat tct gga gac tta gtg gtg tgt gaa acc gtt atc agc      879
 Leu Lys Ile Tyr Ser Gly Asp Leu Val Val Cys Glu Thr Val Ile Ser
         255                 260                 265

 tat tat act gac atg gaa gaa att ggg aat tta ttg tcc aat gcc gcg      927
 Tyr Tyr Thr Asp Met Glu Glu Ile Gly Asn Leu Leu Ser Asn Ala Ala
     270                 275                 280

 aat cct gtg gaa ttc atg tgt cag gcc ttt aaa att gtg ccc tac aac      975
 Asn Pro Val Glu Phe Met Cys Gln Ala Phe Lys Ile Val Pro Tyr Asn
 285                 290                 295                 300

 aca gag acc ctt gat aaa ctg cta acc gaa tcc ctg aag aac aat atc     1023
 Thr Glu Thr Leu Asp Lys Leu Leu Thr Glu Ser Leu Lys Asn Asn Ile
                 305                 310                 315

 cct gca agc gga ctg cac ctc ttt gga atc aac cag ctg gaa gaa gaa     1071
 Pro Ala Ser Gly Leu His Leu Phe Gly Ile Asn Gln Leu Glu Glu Glu
             320                 325                 330

 gat atg atg aca aat cag agg gat gaa gag ctg ccc acc ctg ttg cat     1119
 Asp Met Met Thr Asn Gln Arg Asp Glu Glu Leu Pro Thr Leu Leu His
         335                 340                 345

 ttt gct gcg aag tat gga ctg aag aac ctc act gcc ttg ttg ctc acc     1167
 Phe Ala Ala Lys Tyr Gly Leu Lys Asn Leu Thr Ala Leu Leu Leu Thr
     350                 355                 360

 tgc cca gga gcc ctg cag gcg tac agc gtg gcc aac aag cat ggc cac     1215
 Cys Pro Gly Ala Leu Gln Ala Tyr Ser Val Ala Asn Lys His Gly His
 365                 370                 375                 380

 tac ccc aac acc atc gct gag aaa cac ggc ttc agg gac ctg cgg cag     1263
 Tyr Pro Asn Thr Ile Ala Glu Lys His Gly Phe Arg Asp Leu Arg Gln
                 385                 390                 395

 ttc atc gac gag tat gtg gaa acg gtg gac atg ctc aag agt cac att     1311
 Phe Ile Asp Glu Tyr Val Glu Thr Val Asp Met Leu Lys Ser His Ile
             400                 405                 410

 aaa gag gaa ctg atg cac ggg gag gag gct gat gct gtg tac gag tcc     1359
 Lys Glu Glu Leu Met His Gly Glu Glu Ala Asp Ala Val Tyr Glu Ser
         415                 420                 425

 atg gcc cac ctt tcc aca gac ctg ctt atg aaa tgc tcg ctc aac ccc     1407
 Met Ala His Leu Ser Thr Asp Leu Leu Met Lys Cys Ser Leu Asn Pro
     430                 435                 440

 ggc tgt gac gag gat ctc tat gag tcc atg gct gcc ttt gtc cca gct     1455
 Gly Cys Asp Glu Asp Leu Tyr Glu Ser Met Ala Ala Phe Val Pro Ala
 445                 450                 455                 460

 gcc act gaa gac ctc tat gtt gaa atg ctt cag gcc agt aca tct aac     1503
 Ala Thr Glu Asp Leu Tyr Val Glu Met Leu Gln Ala Ser Thr Ser Asn
                 465                 470                 475

 cca atc cct gga gat ggt ttc tct cgg gcc act aag gac tct atg atc     1551
 Pro Ile Pro Gly Asp Gly Phe Ser Arg Ala Thr Lys Asp Ser Met Ile
             480                 485                 490

 cgc aag ttt tta gaa ggc aac agc atg gga atg acc aat ctg gag aga     1599
 Arg Lys Phe Leu Glu Gly Asn Ser Met Gly Met Thr Asn Leu Glu Arg
         495                 500                 505

 gat cag tgc cat ctt ggt cag gaa gaa gat gtt tat cac acg gtg gat     1647
 Asp Gln Cys His Leu Gly Gln Glu Glu Asp Val Tyr His Thr Val Asp
     510                 515                 520

 gac gat gag gcc ttt tct gtg gac ttg gcc agc agg ccc cct gtc cca     1695
 Asp Asp Glu Ala Phe Ser Val Asp Leu Ala Ser Arg Pro Pro Val Pro
 525                 530                 535                 540

 gtg ccc aga cca gag acc act gct cct ggt gct cac cag ctg cct gac     1743
 Val Pro Arg Pro Glu Thr Thr Ala Pro Gly Ala His Gln Leu Pro Asp
                 545                 550                 555

 aac gaa cca tac att ttt aaa gtt ttt gca gaa aaa agt caa gag cgg     1791
 Asn Glu Pro Tyr Ile Phe Lys Val Phe Ala Glu Lys Ser Gln Glu Arg
             560                 565                 570

 cct ggg aat ttc tac gtt tcc tca gag agc atc agg aaa ggg ccg ccc     1839
 Pro Gly Asn Phe Tyr Val Ser Ser Glu Ser Ile Arg Lys Gly Pro Pro
         575                 580                 585

 gtc aga cca tgg agg gac agg ccc cag tca agt ata tat gac cct ttt     1887
 Val Arg Pro Trp Arg Asp Arg Pro Gln Ser Ser Ile Tyr Asp Pro Phe
     590                 595                 600

 gcg gga atg aaa acg cca ggc cag cgg cag ctt atc acc ctc cag gag     1935
 Ala Gly Met Lys Thr Pro Gly Gln Arg Gln Leu Ile Thr Leu Gln Glu
 605                 610                 615                 620

 cag gtg aag ctg ggc att gtc aac gtg gat gag gct gtg ctc cac ttc     1983
 Gln Val Lys Leu Gly Ile Val Asn Val Asp Glu Ala Val Leu His Phe
                 625                 630                 635

 aaa gag tgg cag ctc aac cag aag aaa cga tcg gag tcc ttt cgt ttc     2031
 Lys Glu Trp Gln Leu Asn Gln Lys Lys Arg Ser Glu Ser Phe Arg Phe
             640                 645                 650

 cag cag gaa aat ctt aaa cgg cta aga gac agc atc acc cga aga cag     2079
 Gln Gln Glu Asn Leu Lys Arg Leu Arg Asp Ser Ile Thr Arg Arg Gln
         655                 660                 665

 aga gag aag caa aaa tca gga aag cag aca gac ttg gag atc acg gtc     2127
 Arg Glu Lys Gln Lys Ser Gly Lys Gln Thr Asp Leu Glu Ile Thr Val
     670                 675                 680

 cca att cgg cac tca cag cac ctg cct gca aaa gtg gag ttt gga gtc     2175
 Pro Ile Arg His Ser Gln His Leu Pro Ala Lys Val Glu Phe Gly Val
 685                 690                 695                 700

 tat gag agt ggc ccc agg aaa agt gtc att ccc cct agg acg gag ctg     2223
 Tyr Glu Ser Gly Pro Arg Lys Ser Val Ile Pro Pro Arg Thr Glu Leu
                 705                 710                 715

 aga cga gga gac tgg aaa aca gac agc acc tcc agc aca gca agt agc     2271
 Arg Arg Gly Asp Trp Lys Thr Asp Ser Thr Ser Ser Thr Ala Ser Ser
             720                 725                 730

 aca agt aac cgc tcc agc acc cgg agc ctc ctc agt gtg agc agc ggg     2319
 Thr Ser Asn Arg Ser Ser Thr Arg Ser Leu Leu Ser Val Ser Ser Gly
         735                 740                 745

 atg gaa ggg gac aac gag gat aat gaa gtc cct gag gtt acc aga agt     2367
 Met Glu Gly Asp Asn Glu Asp Asn Glu Val Pro Glu Val Thr Arg Ser
     750                 755                 760

 cgc agt cca ggc ccc cca caa gtg gat ggg aca ccc acc atg tcc ctc     2415
 Arg Ser Pro Gly Pro Pro Gln Val Asp Gly Thr Pro Thr Met Ser Leu
 765                 770                 775                 780

 gag aga ccc ccc agg gtg cct ccg aga gct gcc tca cag agg cct ccg     2463
 Glu Arg Pro Pro Arg Val Pro Pro Arg Ala Ala Ser Gln Arg Pro Pro
                 785                 790                 795

 acc agg gag acc ttc cat cct cct cca cct gtt cca ccc aga gga cgc     2511
 Thr Arg Glu Thr Phe His Pro Pro Pro Pro Val Pro Pro Arg Gly Arg
             800                 805                 810

 tga ttcc acctcctaaa acctgcctac ttcaggactt taagactcac agtcttcagc     2568
 






      <210> 197
      <211> 1005
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (79)..(909)

      <400> 197
 gggataccca cccgtccgcg gacgcgggtt aactgtaggt taaaatttct ttaacttgcc     60

 caaaacgctg aaaagaaa  atg tgg ggc tgt aaa atg tgc ttt ggg att ctc     111
                      Met Trp Gly Cys Lys Met Cys Phe Gly Ile Leu
                        1               5                  10

 gga aaa aag gag tgc tat att aat tca tgt ttt caa gaa ata atg aag      159
 Gly Lys Lys Glu Cys Tyr Ile Asn Ser Cys Phe Gln Glu Ile Met Lys
              15                  20                  25

 aaa aca tca ata tat cac cta cca tca ttt cat tac ttg atg gat tca      207
 Lys Thr Ser Ile Tyr His Leu Pro Ser Phe His Tyr Leu Met Asp Ser
          30                  35                  40

 gaa gct caa gaa gac acc aga gaa gcc tat gat gac aag cag gtg gtc      255
 Glu Ala Gln Glu Asp Thr Arg Glu Ala Tyr Asp Asp Lys Gln Val Val
      45                  50                  55

 aca gag atc atg gca aga tgt ttt att cca act ctg ata aca act act      303
 Thr Glu Ile Met Ala Arg Cys Phe Ile Pro Thr Leu Ile Thr Thr Thr
  60                  65                  70                  75

 tcc tgg gaa agt ttt cat ttt att ggt cat gag att cga att act gag      351
 Ser Trp Glu Ser Phe His Phe Ile Gly His Glu Ile Arg Ile Thr Glu
                  80                  85                  90

 gcc atg gat tgt tat ggt gct gtt gtt tgg cca tcg gcc ctt gtt cta      399
 Ala Met Asp Cys Tyr Gly Ala Val Val Trp Pro Ser Ala Leu Val Leu
              95                 100                 105

 tgc tat ttc ctg gaa aca aat gca aag cag tat aat atg gtt gac aaa      447
 Cys Tyr Phe Leu Glu Thr Asn Ala Lys Gln Tyr Asn Met Val Asp Lys
         110                 115                 120

 aac gtg att gaa att gga gct gga aca ggg cta gtc tcc att gtg gca      495
 Asn Val Ile Glu Ile Gly Ala Gly Thr Gly Leu Val Ser Ile Val Ala
     125                 130                 135

 agt tta ctt ggt gct cac gtg acg gcc aca gat tta ccc gaa tta ctt      543
 Ser Leu Leu Gly Ala His Val Thr Ala Thr Asp Leu Pro Glu Leu Leu
 140                 145                 150                 155

 gga aac ctg caa tat aat att tcc cga aac acc aaa atg aaa agc aag      591
 Gly Asn Leu Gln Tyr Asn Ile Ser Arg Asn Thr Lys Met Lys Ser Lys
                 160                 165                 170

 cat ttg cct cag gtt aaa gaa ctc tcc tgg gga gta gct tta gat aca      639
 His Leu Pro Gln Val Lys Glu Leu Ser Trp Gly Val Ala Leu Asp Thr
             175                 180                 185

 aac ttc ccc agg tct tct aat aat ttt gac tat att ttg gca gcg gat      687
 Asn Phe Pro Arg Ser Ser Asn Asn Phe Asp Tyr Ile Leu Ala Ala Asp
         190                 195                 200

 gtg gtc tac gct cat cct ttc ttg gaa gag ctc ctc att acc ttt gac      735
 Val Val Tyr Ala His Pro Phe Leu Glu Glu Leu Leu Ile Thr Phe Asp
     205                 210                 215

 cat ctg tgc aaa gaa acc acc atc atc ctg tgg gcc atg aaa ttc agg      783
 His Leu Cys Lys Glu Thr Thr Ile Ile Leu Trp Ala Met Lys Phe Arg
 220                 225                 230                 235

 ttg gag aag gaa aat aaa ttt gta gat aga ttt aag gag ttg ttt gac      831
 Leu Glu Lys Glu Asn Lys Phe Val Asp Arg Phe Lys Glu Leu Phe Asp
                 240                 245                 250

 ctg gag gaa att tcc agt ttc cct agc ctg aat att aag ttg tat aaa      879
 Leu Glu Glu Ile Ser Ser Phe Pro Ser Leu Asn Ile Lys Leu Tyr Lys
             255                 260                 265

 gct gtg aag aaa aac cgg agg agc gta tga c atcctcgatg aggatgtgga      930
 Ala Val Lys Lys Asn Arg Arg Ser Val 
         270                 275

 aatgctaagg caatttttag caaataatca ctttaaagaa aaccctgaat aactttatgt    990

 gccactgagt ttccc                                                    1005




      <210> 198
      <211> 714
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (1)..(714)

      <400> 198
  atg tcg agc aaa aag gca aag acc aag acc acc aag aag cgc cct cag      48
  Met Ser Ser Lys Lys Ala Lys Thr Lys Thr Thr Lys Lys Arg Pro Gln
    1               5                  10                  15

 cgt gca aca tcc aat gtg ttt gcc atg ttt gac cag tca cag att cag       96
 Arg Ala Thr Ser Asn Val Phe Ala Met Phe Asp Gln Ser Gln Ile Gln
              20                  25                  30

 gag ttc aaa gag gcc ttc aac atg att gat cag aac aga gat ggc ttc      144
 Glu Phe Lys Glu Ala Phe Asn Met Ile Asp Gln Asn Arg Asp Gly Phe
          35                  40                  45

 atc gac aag gaa gat ttg cat gat atg ctt gct tct cta ggg aag aat      192
 Ile Asp Lys Glu Asp Leu His Asp Met Leu Ala Ser Leu Gly Lys Asn
      50                  55                  60

 ccc act gat gca tac ctt gat gcc atg atg aat gag gcc cca ggg ccc      240
 Pro Thr Asp Ala Tyr Leu Asp Ala Met Met Asn Glu Ala Pro Gly Pro
  65                  70                  75                  80

 atc aat ttc acc atg ttc ctg acc atg ttt ggt gag aag tta aat ggc      288
 Ile Asn Phe Thr Met Phe Leu Thr Met Phe Gly Glu Lys Leu Asn Gly
                  85                  90                  95

 aca gat cct gaa gat gtc atc aga aac gcc ttt gct tgc ttt gat gaa      336
 Thr Asp Pro Glu Asp Val Ile Arg Asn Ala Phe Ala Cys Phe Asp Glu
             100                 105                 110

 gaa gca aca ggc acc att cag gaa gat tac cta aga gag ctg ctg aca      384
 Glu Ala Thr Gly Thr Ile Gln Glu Asp Tyr Leu Arg Glu Leu Leu Thr
         115                 120                 125

 acc atg ggg gat cgg ttt aca gat gag gaa gtg gat gag ctg tac aga      432
 Thr Met Gly Asp Arg Phe Thr Asp Glu Glu Val Asp Glu Leu Tyr Arg
     130                 135                 140

 gaa gca cct att gac aaa aag ggg aat ttc aat tac atc gag ttc aca      480
 Glu Ala Pro Ile Asp Lys Lys Gly Asn Phe Asn Tyr Ile Glu Phe Thr
 145                 150                 155                 160

 cgc atc ctg aaa cat gga gcc aag aca aag atg act gaa aga act tta      528
 Arg Ile Leu Lys His Gly Ala Lys Thr Lys Met Thr Glu Arg Thr Leu
                 165                 170                 175

 gct aaa atc ttc cag tta cat tgt ctt act ctc ttt tac ttc tca gac      576
 Ala Lys Ile Phe Gln Leu His Cys Leu Thr Leu Phe Tyr Phe Ser Asp
             180                 185                 190

 act tcc ccc acc ctc ata gaa cct gtt gca tgc aac tta gtt tca cag      624
 Thr Ser Pro Thr Leu Ile Glu Pro Val Ala Cys Asn Leu Val Ser Gln
         195                 200                 205

 ctt tgc ctc ttc ttt ttg atg tat tta ttc cag acc ttt ctg cca ctt      672
 Leu Cys Leu Phe Phe Leu Met Tyr Leu Phe Gln Thr Phe Leu Pro Leu
     210                 215                 220

 agc act tgt ata atc aga ctg gaa atg ggg atg agg gtg taa              714
 Ser Thr Cys Ile Ile Arg Leu Glu Met Gly Met Arg Val 
 225                 230                 235





      <210> 199
      <211> 979
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (90)..(572)

      <400> 199
 cccaggcttc tggtggagga agagaaggca ccgtcagcag ccacaaggat accctgtgtt     60

 ccctgggggg tggagcatgg gtgcctctc  atg gag ggc tgg ggc ggt gga ggc     113
                                  Met Glu Gly Trp Gly Gly Gly Gly
                                    1               5

 acg cac agg tgt gta agc gag cga agt cct ctg agg gca ttc tta gag      161
 Thr His Arg Cys Val Ser Glu Arg Ser Pro Leu Arg Ala Phe Leu Glu
      10                  15                  20

 atg gag cca atc tca ttg tcc tcg atg aag ggc ggg ctc ccc ggg ccc      209
 Met Glu Pro Ile Ser Leu Ser Ser Met Lys Gly Gly Leu Pro Gly Pro
  25                  30                  35                  40

 cca ttg gct gca ggc ccc ccc acg cca ggg ctc ccc cca gct ccc ccc      257
 Pro Leu Ala Ala Gly Pro Pro Thr Pro Gly Leu Pro Pro Ala Pro Pro
                  45                  50                  55

 cac atc ggt ccg tcc tgc ttc cag ctg ctg cag cgc gcc ttc gcc gcc      305
 His Ile Gly Pro Ser Cys Phe Gln Leu Leu Gln Arg Ala Phe Ala Ala
              60                  65                  70

 aaa gca tcc agc agc ccc ctg ctc cgg ccc agc atg gcg acc ccg acc      353
 Lys Ala Ser Ser Ser Pro Leu Leu Arg Pro Ser Met Ala Thr Pro Thr
          75                  80                  85

 cag acc ccc aca aag gct cct gag gaa cct gac cca ttt tac tat gac      401
 Gln Thr Pro Thr Lys Ala Pro Glu Glu Pro Asp Pro Phe Tyr Tyr Asp
      90                  95                 100

 tac aac acg gtg cag act gtg ggc atg act ctg gca acc atc ttg ttc      449
 Tyr Asn Thr Val Gln Thr Val Gly Met Thr Leu Ala Thr Ile Leu Phe
 105                 110                 115                 120

 ctg ctg ggt atc ctc atc gtc atc agc aag aag gtg aag tgc agg aag      497
 Leu Leu Gly Ile Leu Ile Val Ile Ser Lys Lys Val Lys Cys Arg Lys
                 125                 130                 135

 gcg gac tcc agc cca acc tgc aaa tcc tgt aag tct gag ctt ccc tct      545
 Ala Asp Ser Ser Pro Thr Cys Lys Ser Cys Lys Ser Glu Leu Pro Ser
             140                 145                 150

 tca gcc cct ggt ggc ggc ggc gtg taa cacct tcccgaggaa actccgctgc      597
 Ser Ala Pro Gly Gly Gly Gly Val 
         155                 160

 cgaccctgcc tgagcgcggg agcctgagga ccgggtggag gcggtgggga cccagccgcg    657

 cgccgggagc gctccccgga atgagccgcc ccacccaccc caaggctgga gccgctgcac    717

 cctgctgtcc ctctccaggc cttggcaatg acgatccccc aaagagcccg tctgcacccc    777

 agacccaggg cctcaggcct ccagctcctg ggatccggga gtccatcccg gcccagcacc    837

 cccagcatcc ccgtgtatgg cccccctgca cctccttgtc tcatccccga agatccgtcc    897

 ccctggcccc tcagtgtcca tgtcttgagc ttaataaatg tgcatttggt tttttcctca    957

 aaaaaaaaaa aaaaaaacct at                                             979




      <210> 200
      <211> 1364
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (111)..(1364)

      <400> 200
 aggtgggaag gcagttatga cagttgagaa gtagtagaag acacggaagg cacagaaggc     60

 agacttcgct cagcacaaag aagaattttc tgataaccat actgggcaaa   atg aac     116
                                                          Met Asn
                                                            1

 tgg gct gcc ttc gga ggg tct gaa ttc ttc atc cca gaa ggc att cag      164
 Trp Ala Ala Phe Gly Gly Ser Glu Phe Phe Ile Pro Glu Gly Ile Gln
           5                  10                  15

 ata gat tcg aga tgc cca cta agc aga aat atc acg gaa tgg tac cat      212
 Ile Asp Ser Arg Cys Pro Leu Ser Arg Asn Ile Thr Glu Trp Tyr His
      20                  25                  30

 tac tat ggc att gca gtg aaa gaa agc tcc caa tat tat gat gtg atg      260
 Tyr Tyr Gly Ile Ala Val Lys Glu Ser Ser Gln Tyr Tyr Asp Val Met
  35                  40                  45                  50

 tat tcc aag aaa gga gct gcc tgg gtg agt gag acg ggc aag aaa gaa      308
 Tyr Ser Lys Lys Gly Ala Ala Trp Val Ser Glu Thr Gly Lys Lys Glu
                  55                  60                  65

 gtg agc aaa cag aca gtg gca tat tca ccc cgg tcc aaa ctc gga aca      356
 Val Ser Lys Gln Thr Val Ala Tyr Ser Pro Arg Ser Lys Leu Gly Thr
              70                  75                  80

 ctg ctg cca gaa ttt ccc aat gtc aaa gat cta aat ctg cca gcc agc      404
 Leu Leu Pro Glu Phe Pro Asn Val Lys Asp Leu Asn Leu Pro Ala Ser
          85                  90                  95

 ctg cct gag gag aag gtt tct acc ttt att atg atg tac aga aca cac      452
 Leu Pro Glu Glu Lys Val Ser Thr Phe Ile Met Met Tyr Arg Thr His
     100                 105                 110

 tgt cag aga ata ctg gac act gta ata aga gcc aac ttt gat gag gtt      500
 Cys Gln Arg Ile Leu Asp Thr Val Ile Arg Ala Asn Phe Asp Glu Val
 115                 120                 125                 130

 caa agt ttc ctt ctg cac ttt tgg caa gga atg ccg ccc cac atg ctg      548
 Gln Ser Phe Leu Leu His Phe Trp Gln Gly Met Pro Pro His Met Leu
                 135                 140                 145

 cct gtg ctg ggc tcc tcc acg gtg gtg aac att gtc ggc gtg tgt gac      596
 Pro Val Leu Gly Ser Ser Thr Val Val Asn Ile Val Gly Val Cys Asp
             150                 155                 160

 tcc atc ctc tac aaa gct atc tcc ggg gtg ctg atg ccc act gtg ctg      644
 Ser Ile Leu Tyr Lys Ala Ile Ser Gly Val Leu Met Pro Thr Val Leu
         165                 170                 175

 cag gca tta cct gac agc tta act cag gtg att cga aag ttt gcc aag      692
 Gln Ala Leu Pro Asp Ser Leu Thr Gln Val Ile Arg Lys Phe Ala Lys
     180                 185                 190

 caa ctg gat gag tgg cta aaa gtg gct ctc cac gac ctc cca gaa aac      740
 Gln Leu Asp Glu Trp Leu Lys Val Ala Leu His Asp Leu Pro Glu Asn
 195                 200                 205                 210

 ttg cga aac atc aag ttc gaa tat gag gct cta aga ggc aaa gag agt      788
 Leu Arg Asn Ile Lys Phe Glu Tyr Glu Ala Leu Arg Gly Lys Glu Ser
                 215                 220                 225

 tct ccc aaa gct gcg ccg cca cac atc tct aaa tca tct ctg cca ggc      836
 Ser Pro Lys Ala Ala Pro Pro His Ile Ser Lys Ser Ser Leu Pro Gly
             230                 235                 240

 atc tcg aac agg atc cac agt gca gac atc acg ttc caa atg ctg gaa      884
 Ile Ser Asn Arg Ile His Ser Ala Asp Ile Thr Phe Gln Met Leu Glu
         245                 250                 255

 gac tgg agg aac gtg gac ctg aac agc atc acc aag caa acc ctt tac      932
 Asp Trp Arg Asn Val Asp Leu Asn Ser Ile Thr Lys Gln Thr Leu Tyr
     260                 265                 270

 acc atg gaa gac tct cgc gat gag cac cgg aaa ctc atc acc caa tac      980
 Thr Met Glu Asp Ser Arg Asp Glu His Arg Lys Leu Ile Thr Gln Tyr
 275                 280                 285                 290

 gta gct ctt gtt aaa tac aac tgc agt gat gcg tgt ggg gtt ctc ctt     1028
 Val Ala Leu Val Lys Tyr Asn Cys Ser Asp Ala Cys Gly Val Leu Leu
                 295                 300                 305

 tgt ttg aca gta tat cag gag ttt gac cat ctc ttg gag gag cag tct     1076
 Cys Leu Thr Val Tyr Gln Glu Phe Asp His Leu Leu Glu Glu Gln Ser
             310                 315                 320

 ccc atc gag tcc tac att gag tgg ctg gat acc atg gtt gac cgc tgt     1124
 Pro Ile Glu Ser Tyr Ile Glu Trp Leu Asp Thr Met Val Asp Arg Cys
         325                 330                 335

 gtt gtg aag gtt ggt ggc tgc caa gag aca agg gtc ctt gaa gaa agt     1172
 Val Val Lys Val Gly Gly Cys Gln Glu Thr Arg Val Leu Glu Glu Ser
     340                 345                 350

 ggc cca gca gtt cct ctt gat gtg gtc ctg ttt cgg cac aag ggt gat     1220
 Gly Pro Ala Val Pro Leu Asp Val Val Leu Phe Arg His Lys Gly Asp
 355                 360                 365                 370

 ccg gga cat gac ctt gca cag cgc ccc cag ctt cgt ctt tct gta tct     1268
 Pro Gly His Asp Leu Ala Gln Arg Pro Gln Leu Arg Leu Ser Val Ser
                 375                 380                 385

 cct ttt cat ttt cct gtc ttc atc gat att cac tat cct cat cgc tgc     1316
 Pro Phe His Phe Pro Val Phe Ile Asp Ile His Tyr Pro His Arg Cys
             390                 395                 400

 gac act ctg gca atg aac tgt tta ctg ccc aat aat ctt aat gat taa     1364
 Asp Thr Leu Ala Met Asn Cys Leu Leu Pro Asn Asn Leu Asn Asp 
         405                 410                 415





      <210> 201
      <211> 1729
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (7)..(1083)

      <400> 201
 tttgag   atg ggc ggt tcc gaa gga att gtg gag tct ata caa att atg      48
          Met Gly Gly Ser Glu Gly Ile Val Glu Ser Ile Gln Ile Met
            1               5                  10

 aag gaa ggc aaa gct act gct agc gag gct gtt gat tgc aag tgg tac       96
 Lys Glu Gly Lys Ala Thr Ala Ser Glu Ala Val Asp Cys Lys Trp Tyr
  15                  20                  25                  30

 atc cga gca cct cca cgg tcc aag att tac tta cga ttc ttg gac tat      144
 Ile Arg Ala Pro Pro Arg Ser Lys Ile Tyr Leu Arg Phe Leu Asp Tyr
                  35                  40                  45

 gag atg cag aat tca aat gag tgc aag agg aat ttt gtg gct gtg tat      192
 Glu Met Gln Asn Ser Asn Glu Cys Lys Arg Asn Phe Val Ala Val Tyr
              50                  55                  60

 gat gga agc agt tcc gtg gag gat ttg aaa gct aag ttc tgt agc act      240
 Asp Gly Ser Ser Ser Val Glu Asp Leu Lys Ala Lys Phe Cys Ser Thr
          65                  70                  75

 gtg gct aat gat gtc atg cta cgc acg ggt ctt ggg gtg atc cgc atg      288
 Val Ala Asn Asp Val Met Leu Arg Thr Gly Leu Gly Val Ile Arg Met
      80                  85                  90

 tgg gca gat gag ggc agt cga aac agc cga ttt cag atg ctc ttc aca      336
 Trp Ala Asp Glu Gly Ser Arg Asn Ser Arg Phe Gln Met Leu Phe Thr
  95                 100                 105                 110

 tcc ttt caa gaa cct cct tgt gaa ggc aac aca ttc ttc tgc cat agt      384
 Ser Phe Gln Glu Pro Pro Cys Glu Gly Asn Thr Phe Phe Cys His Ser
                 115                 120                 125

 aac atg tgt att aat aat act ttg gtc tgc aat gga ctc caa aac tgt      432
 Asn Met Cys Ile Asn Asn Thr Leu Val Cys Asn Gly Leu Gln Asn Cys
             130                 135                 140

 gtg tat cct tgg gat gaa aat cac tgt aaa gag aag agg aaa acc agc      480
 Val Tyr Pro Trp Asp Glu Asn His Cys Lys Glu Lys Arg Lys Thr Ser
         145                 150                 155

 ctg ctg gac cag ctg acc aac acc agt ggg act gtc att ggc gtg act      528
 Leu Leu Asp Gln Leu Thr Asn Thr Ser Gly Thr Val Ile Gly Val Thr
     160                 165                 170

 tcc tgc atc ggg atc atc ctc att atc atc tct gtc atc gta cag atc      576
 Ser Cys Ile Gly Ile Ile Leu Ile Ile Ile Ser Val Ile Val Gln Ile
 175                 180                 185                 190

 aaa cag cct cgt aaa aag tat gtc caa agg aaa tca gac ttt gac cag      624
 Lys Gln Pro Arg Lys Lys Tyr Val Gln Arg Lys Ser Asp Phe Asp Gln
                 195                 200                 205

 aca gtt ttc cag gag gta ttt gaa cct cct cat tat gag tta tgc act      672
 Thr Val Phe Gln Glu Val Phe Glu Pro Pro His Tyr Glu Leu Cys Thr
             210                 215                 220

 ctc aga ggg aca gga gct aca gct gac ttt gca gat gtg gca gat gac      720
 Leu Arg Gly Thr Gly Ala Thr Ala Asp Phe Ala Asp Val Ala Asp Asp
         225                 230                 235

 ttt gaa aat tac cat aaa ctg cgg agg tca tct tcc aaa tgc att cat      768
 Phe Glu Asn Tyr His Lys Leu Arg Arg Ser Ser Ser Lys Cys Ile His
     240                 245                 250

 gac cat cac tgt gga tca cag ctg tcc agc act aaa ggc agc cgc agt      816
 Asp His His Cys Gly Ser Gln Leu Ser Ser Thr Lys Gly Ser Arg Ser
 255                 260                 265                 270

 aac ctc agc aca aga gat gct tct atc ttg aca gag atg ccc aca cag      864
 Asn Leu Ser Thr Arg Asp Ala Ser Ile Leu Thr Glu Met Pro Thr Gln
                 275                 280                 285

 cca gga aaa ccc ctc atc cca ccc atg aac aga aga aat atc ctt gtc      912
 Pro Gly Lys Pro Leu Ile Pro Pro Met Asn Arg Arg Asn Ile Leu Val
             290                 295                 300

 atg aaa cac aac tac tcg caa gat gct gca gat gcc tgt gac ata gat      960
 Met Lys His Asn Tyr Ser Gln Asp Ala Ala Asp Ala Cys Asp Ile Asp
         305                 310                 315

 gaa atc gaa gag gtg ccg acc acc agt cac agg ctg tcc aga cac gat     1008
 Glu Ile Glu Glu Val Pro Thr Thr Ser His Arg Leu Ser Arg His Asp
     320                 325                 330

 aaa gcc gtc cag cgg ttc tgc ctc att ggg tct cta agc aaa cat gaa     1056
 Lys Ala Val Gln Arg Phe Cys Leu Ile Gly Ser Leu Ser Lys His Glu
 335                 340                 345                 350

 tct gaa tac aac aca act agg gtc tag aaaga aaattcaaga gaagaactat     1108
 Ser Glu Tyr Asn Thr Thr Arg Val 
                 355

 ttatacaaac atggggactg tgaaaagaaa attctatagt gaattgtgaa aaagtggaca   1168

 tatttctaaa ttcattccac tgcctttatc caaacttaag aattacagac atttgttatt   1228

 ccttcggcaa gacatccccg ctgcacactg atatgttcat ttcgtaattt ggttgctggc   1288

 caccaagtgc tccttagttt ttaaatacat tttgagatta actggaaact tgaagaagaa   1348

 attagttccc gattaagact atcccaactt tatttttatt gtcagtttca cttttgtttc   1408

 tatgttgttt tatgtctttg ttatataatt gtacattgtg tgatatgtga aaaaaaaaca   1468

 cgaattggat gaaccttgtg ttacatgtac atgtccctta tatacaccgt tgagaatagt   1528

 gcgttcctga atgatttgaa catgcaccgt gcacgtgccg cgtggcggat cccacttaag   1588

 gttggcaaac acccatttta ttgttatccg gaagccgtaa tccactgcca cacaccctcg   1648

 gccaaacaaa aaaagggcgc aacaacggcg ccaaaagaca ccaacgggtg ggcaacgggc   1708

 gaagtgtatg acccacccac a                                             1729




      <210> 202
      <211> 1347
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (552)..(1088)

      <220>
      <221> misc_feature
      <222> (1)...(1347)
      <223> n = a,t,c or g

      <400> 202
 ccgtgggttc acagtctggt cctgggggtt ttgcttgggt tgggctccag ctcacaccct     60

 ccctaaaagg aaatgggaga aaggcccggc caaacaagag ggttaaggtt agagaagggg    120

 gacacaaatg tcttcaggct taggtccctg ggggctccca gtcctgcccc tgttcctcta    180

 ctcacatccc agctcctccc agtttctttt cggacctcct cctctcccct tccttctcta    240

 ttccaggctg ggttgggctt taagcaaggg gagggattag agcctccttc ctctctgccc    300

 ctccccatgg gtctctaggg ggctggtgca ggcagcagca gaggcactct gggcagctgg    360

 gtgagggccc atctgggcaa ggcccccagc gcctgccttc tctcccgggg ccctgtgggc    420

 aagcctcctg cttcactttc aggtttctcg aagtgccttc ttgctcctgt ctgtttcccc    480

 atcctgccag atttctgttt ctcttgctgg gcttttggca gtagggggct gtgttggtgg    540

 gccctacgaa g atg ctc agt gct cga gat cgc cgg gac cgg cac cct gag     590
              Met Leu Ser Ala Arg Asp Arg Arg Asp Arg His Pro Glu
                1               5                  10

 gag ggg gta gtt gca gag ctc cag ggc ttc gcg gtg gac aag gcc ttc      638
 Glu Gly Val Val Ala Glu Leu Gln Gly Phe Ala Val Asp Lys Ala Phe
      15                  20                  25

 ctc acc tcc cac aag ggc atc ctg ctg gaa acc gag ctg gcc ctg acc      686
 Leu Thr Ser His Lys Gly Ile Leu Leu Glu Thr Glu Leu Ala Leu Thr
  30                  35                  40                  45

 ctc atc atc ttc atc tgc ttc acg gcc tcc atc tct gcc tac atg gcc      734
 Leu Ile Ile Phe Ile Cys Phe Thr Ala Ser Ile Ser Ala Tyr Met Ala
                  50                  55                  60

 gcg gcg cta ctg gag ttc ttc atc aca ctt gcc ttc ctc ttc ctc tat      782
 Ala Ala Leu Leu Glu Phe Phe Ile Thr Leu Ala Phe Leu Phe Leu Tyr
              65                  70                  75

 gcc acc cag tac tac cag cgc ttc gac cga att aac tgg ccc tgt ctg      830
 Ala Thr Gln Tyr Tyr Gln Arg Phe Asp Arg Ile Asn Trp Pro Cys Leu
          80                  85                  90

 gac ttc ctg cgc tgt gtc agt gcc atc atc atc ttc ctg gtg gtc tcc      878
 Asp Phe Leu Arg Cys Val Ser Ala Ile Ile Ile Phe Leu Val Val Ser
      95                 100                 105

 ttt gca gct gtg acc tcc cgg gac gga gct gcc att gct gct ttt gtt      926
 Phe Ala Ala Val Thr Ser Arg Asp Gly Ala Ala Ile Ala Ala Phe Val
 110                 115                 120                 125

 ttt ggc atc atc ctg gtt tcc atc ttt gcc tat gat gcc ttc aag atc      974
 Phe Gly Ile Ile Leu Val Ser Ile Phe Ala Tyr Asp Ala Phe Lys Ile
                 130                 135                 140

 tac cgg act gag atg gca ccc ggg gca gcc agg ggg acc agc agt gac     1022
 Tyr Arg Thr Glu Met Ala Pro Gly Ala Ala Arg Gly Thr Ser Ser Asp
             145                 150                 155

 tct ggg gct aac tgg ctc cta agc cca gca gca gag agg aaa gtg gag     1070
 Ser Gly Ala Asn Trp Leu Leu Ser Pro Ala Ala Glu Arg Lys Val Glu
         160                 165                 170

 ccc aga cac gtc tct tga ttatta tagcccagcg ctaaacccaa ccaagcctaa     1124
 Pro Arg His Val Ser 
     175

 agnagttggc tggagtactg ggaattatct tggagctgtg tcaggattgg tatcatgaat   1184

 ttgcaagagg gacatggggg gggggaggga gaaattgacc tagctcccat aattattaaa   1244

 aaaaggggcc taatctcagg ccataccact tttaaggcta ataggttaat aagggaaagg   1304

 aaaagttgac tgttagacaa ccagattttt gttatatatc cgc                     1347




      <210> 203
      <211> 476
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (11)..(334)

      <400> 203
 agctgagggc   atg gcg tcc gga gcg gct cgc tgg cta gta ttg gca ccc      49
              Met Ala Ser Gly Ala Ala Arg Trp Leu Val Leu Ala Pro
                1               5                  10

 gac agg tcc ggg gct ctc cag acc gga cct agc ttg agg aaa cac ggc       97
 Asp Arg Ser Gly Ala Leu Gln Thr Gly Pro Ser Leu Arg Lys His Gly
      15                  20                  25

 gat gtc tcc gcc gca tgg agc ggc tca agc cgg agc ctg gta cct gtg      145
 Asp Val Ser Ala Ala Trp Ser Gly Ser Ser Arg Ser Leu Val Pro Val
  30                  35                  40                  45

 agg tca tac ata gtt acc cgc agc ggc gcc att ttg ccc aaa ccg ggg      193
 Arg Ser Tyr Ile Val Thr Arg Ser Gly Ala Ile Leu Pro Lys Pro Gly
                  50                  55                  60

 aaa acg gac atc ggc ctt ctc cgt gtg ttc tcc att gtg atc ccc ttt      241
 Lys Thr Asp Ile Gly Leu Leu Arg Val Phe Ser Ile Val Ile Pro Phe
              65                  70                  75

 ctc tat gtc ggg aca ctc att agc aag aac ttt gct gct cta ctt gag      289
 Leu Tyr Val Gly Thr Leu Ile Ser Lys Asn Phe Ala Ala Leu Leu Glu
          80                  85                  90

 gaa cat gac att ttt gtt cca gag gat gat gat gat gat gac taa cag      337
 Glu His Asp Ile Phe Val Pro Glu Asp Asp Asp Asp Asp Asp 
      95                 100                 105

 gtaagacttg ctttacccta gatggagcag gaagcagggt ggagcatctg tctgtgatgc    397

 agtctggcct ggtagcagca tttggacact gggggcagaa gcattaatga attggcccac    457

 ttggtggcta atgttttcg                                                 476




      <210> 204
      <211> 1087
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (38)..(1087)

      <400> 204
 ccctagtgcc ccagcaaggg ttcttaacca ggctgaa atg gct gaa atg aca gaa      55
                                          Met Ala Glu Met Thr Glu
                                            1               5

 gta gaa ttc aga ata tgg ata gga aca aaa atc atc aag att caa gag      103
 Val Glu Phe Arg Ile Trp Ile Gly Thr Lys Ile Ile Lys Ile Gln Glu
              10                  15                  20

 aaa gtc aaa acc caa tcc aag gaa tct aag gaa tac cat aaa atg ata      151
 Lys Val Lys Thr Gln Ser Lys Glu Ser Lys Glu Tyr His Lys Met Ile
          25                  30                  35

 caa gag ctg aaa gat gaa atg gcc att tta aga aag aac caa act gat      199
 Gln Glu Leu Lys Asp Glu Met Ala Ile Leu Arg Lys Asn Gln Thr Asp
      40                  45                  50

 ctg ata gag ctc aaa aac tca cta tat gaa ttt cat aat aca atc aca      247
 Leu Ile Glu Leu Lys Asn Ser Leu Tyr Glu Phe His Asn Thr Ile Thr
  55                  60                  65                  70

 agc gtt agc agc aga ata gac caa act gag gaa aga atc tct gag ctt      295
 Ser Val Ser Ser Arg Ile Asp Gln Thr Glu Glu Arg Ile Ser Glu Leu
                  75                  80                  85

 gaa gac tgg ttc tcc aaa gtt ctt gcc atg ggt gac aag gga aca ggc      343
 Glu Asp Trp Phe Ser Lys Val Leu Ala Met Gly Asp Lys Gly Thr Gly
              90                  95                 100

 aac cat tca gat gta act gat ttc att ctt gaa ggc ttc agg gtc cgc      391
 Asn His Ser Asp Val Thr Asp Phe Ile Leu Glu Gly Phe Arg Val Arg
         105                 110                 115

 cca gag ttc tac att ctc ctc ttc ttc ctg ttc ctg ctg atc tat agc      439
 Pro Glu Phe Tyr Ile Leu Leu Phe Phe Leu Phe Leu Leu Ile Tyr Ser
     120                 125                 130

 atg gtt ctt ttg ggg aac att agt gtg atg aca atc att gta act gat      487
 Met Val Leu Leu Gly Asn Ile Ser Val Met Thr Ile Ile Val Thr Asp
 135                 140                 145                 150

 tcc cag ctg aac aca cca atg tat ttt ttt cta ggc aac ctc tcc ttc      535
 Ser Gln Leu Asn Thr Pro Met Tyr Phe Phe Leu Gly Asn Leu Ser Phe
                 155                 160                 165

 att gac gtc tcc tac tcc act gtt att gct cct aaa gcc atg gcc cac      583
 Ile Asp Val Ser Tyr Ser Thr Val Ile Ala Pro Lys Ala Met Ala His
             170                 175                 180

 ttc ctg tct gaa aaa aag aca gtc tct ttt gca ggt tgt gtt gcc cag      631
 Phe Leu Ser Glu Lys Lys Thr Val Ser Phe Ala Gly Cys Val Ala Gln
         185                 190                 195

 tta ttc ctt ttt gcc ctg ttc att gta aca gag ggg ttt gtc ctg gca      679
 Leu Phe Leu Phe Ala Leu Phe Ile Val Thr Glu Gly Phe Val Leu Ala
     200                 205                 210

 gcc atg gcc tat gac cgc ttc agt gcc atc tgc aat cct ctt ctt cat      727
 Ala Met Ala Tyr Asp Arg Phe Ser Ala Ile Cys Asn Pro Leu Leu His
 215                 220                 225                 230

 agt gtt cac atg tca aga cgc ctc tgc act cag ttg gtt gct ggt tct      775
 Ser Val His Met Ser Arg Arg Leu Cys Thr Gln Leu Val Ala Gly Ser
                 235                 240                 245

 tat ttc tgt ggc tgg gcc agt tcc atc ctc caa gtc agt gta aca ttc      823
 Tyr Phe Cys Gly Trp Ala Ser Ser Ile Leu Gln Val Ser Val Thr Phe
             250                 255                 260

 tca gtg tcc ttc tgt gct tcc aga gtc att gct cac ttc tac tgt gat      871
 Ser Val Ser Phe Cys Ala Ser Arg Val Ile Ala His Phe Tyr Cys Asp
         265                 270                 275

 tct tat caa att gaa aag att tcc tgt tct aat ctc ttt gtc aat aag      919
 Ser Tyr Gln Ile Glu Lys Ile Ser Cys Ser Asn Leu Phe Val Asn Lys
     280                 285                 290

 atg gta tct ctg agt ttg agt gtc atc att att ttg cct aca att gtt      967
 Met Val Ser Leu Ser Leu Ser Val Ile Ile Ile Leu Pro Thr Ile Val
 295                 300                 305                 310

 gtt att ata gta tct tac ctg tat att gta tcc tca gtc ttg aag atc     1015
 Val Ile Ile Val Ser Tyr Leu Tyr Ile Val Ser Ser Val Leu Lys Ile
                 315                 320                 325

 ccc tcc agt gaa ggg aga aag aaa gac ttt tcc act tgc agc tcc cat     1063
 Pro Ser Ser Glu Gly Arg Lys Lys Asp Phe Ser Thr Cys Ser Ser His
             330                 335                 340

 cgg ggt gtt gta agt ttg ctc taa                                     1087
 Arg Gly Val Val Ser Leu Leu 
         345





      <210> 205
      <211> 1155
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (1)..(1155)

      <400> 205
  atg ctg acg tca atg gcc tat gat tgc tgt gtg gcc atc tgt tac ccg      48
  Met Leu Thr Ser Met Ala Tyr Asp Cys Cys Val Ala Ile Cys Tyr Pro
    1               5                  10                  15

 ctt ctg tat aac att gcc atg tcc cct aaa gtg tgt tcc agc cat atg       96
 Leu Leu Tyr Asn Ile Ala Met Ser Pro Lys Val Cys Ser Ser His Met
              20                  25                  30

 ctt ggt tcc tac ttc tgg ccc ttt tct ggg gcc atg gcc cat acc agg      144
 Leu Gly Ser Tyr Phe Trp Pro Phe Ser Gly Ala Met Ala His Thr Arg
          35                  40                  45

 tgc atg ctg aaa ctg acc tcc tgt gag gca aac acc atc aat cac tac      192
 Cys Met Leu Lys Leu Thr Ser Cys Glu Ala Asn Thr Ile Asn His Tyr
      50                  55                  60

 ttc cgt gac acc ctt cat gtg ttc cag ctc tcc tgc acc agc acc tac      240
 Phe Arg Asp Thr Leu His Val Phe Gln Leu Ser Cys Thr Ser Thr Tyr
  65                  70                  75                  80

 atc agg gct gag ttt atc ctg gca ggc ttg aca caa cgc cca gaa ctt      288
 Ile Arg Ala Glu Phe Ile Leu Ala Gly Leu Thr Gln Arg Pro Glu Leu
                  85                  90                  95

 caa ctg cca ctc ttc ctc ctg ttc ctt gga ata tat gtg gtc aca gtg      336
 Gln Leu Pro Leu Phe Leu Leu Phe Leu Gly Ile Tyr Val Val Thr Val
             100                 105                 110

 gtg ggg aac ctg ggc atg atc ttc tta att gct ctc agt tct caa ctt      384
 Val Gly Asn Leu Gly Met Ile Phe Leu Ile Ala Leu Ser Ser Gln Leu
         115                 120                 125

 tac cct cca gtg tat tat ttt ctc agt cat ttg tct ttc att gat ctc      432
 Tyr Pro Pro Val Tyr Tyr Phe Leu Ser His Leu Ser Phe Ile Asp Leu
     130                 135                 140

 tgc tac tcc tct gtc att acc cct aag atg ctg gtg aac ttt gtt cca      480
 Cys Tyr Ser Ser Val Ile Thr Pro Lys Met Leu Val Asn Phe Val Pro
 145                 150                 155                 160

 gag gag aac att atc tcc ttt ctg gaa tgc att act caa ctt tat ttc      528
 Glu Glu Asn Ile Ile Ser Phe Leu Glu Cys Ile Thr Gln Leu Tyr Phe
                 165                 170                 175

 ttc ctt att ttt gta att gca gaa ggc tac ctt ctg aca gcc atg gaa      576
 Phe Leu Ile Phe Val Ile Ala Glu Gly Tyr Leu Leu Thr Ala Met Glu
             180                 185                 190

 tat gac cgt tat gtt gct atc tgt cgc cca ctg ctt tac aat att gtc      624
 Tyr Asp Arg Tyr Val Ala Ile Cys Arg Pro Leu Leu Tyr Asn Ile Val
         195                 200                 205

 atg tcc cac agg gtc tgt tcc ata atg atg gct gtg gta tac tca ctg      672
 Met Ser His Arg Val Cys Ser Ile Met Met Ala Val Val Tyr Ser Leu
     210                 215                 220

 ggt ttt ctg tgg gcc aca gtc cat act acc cgc atg tca gtg ttg tca      720
 Gly Phe Leu Trp Ala Thr Val His Thr Thr Arg Met Ser Val Leu Ser
 225                 230                 235                 240

 ttc tgt agg tct cat acg gtc agt cat tat ttt tgt gat att ctc ccc      768
 Phe Cys Arg Ser His Thr Val Ser His Tyr Phe Cys Asp Ile Leu Pro
                 245                 250                 255

 tta ttg act ctg tct tgc tcc agc acc cac atc aat gag att ctg ctg      816
 Leu Leu Thr Leu Ser Cys Ser Ser Thr His Ile Asn Glu Ile Leu Leu
             260                 265                 270

 ttc att att gga gga gtt aat acc tta gca act aca ctg gcg gtc ctt      864
 Phe Ile Ile Gly Gly Val Asn Thr Leu Ala Thr Thr Leu Ala Val Leu
         275                 280                 285

 atc tct tat gct ttc att ttc tct agt atc ctt ggt att cat tcc act      912
 Ile Ser Tyr Ala Phe Ile Phe Ser Ser Ile Leu Gly Ile His Ser Thr
     290                 295                 300

 gag ggg caa tcc aaa gcc ttt ggc act tgt agc tcc cat ctc ttg gct      960
 Glu Gly Gln Ser Lys Ala Phe Gly Thr Cys Ser Ser His Leu Leu Ala
 305                 310                 315                 320

 gtg ggc atc ttt ttt ggg tct ata aca ttc atg tat ttc aag ccc cct     1008
 Val Gly Ile Phe Phe Gly Ser Ile Thr Phe Met Tyr Phe Lys Pro Pro
                 325                 330                 335

 tcc agc act act atg gaa aaa gag aag gtg tct tct gtg ttc tac atc     1056
 Ser Ser Thr Thr Met Glu Lys Glu Lys Val Ser Ser Val Phe Tyr Ile
             340                 345                 350

 aca ata atc ccc atg ctg aat cct cta atc tat agc ctg agg aac aag     1104
 Thr Ile Ile Pro Met Leu Asn Pro Leu Ile Tyr Ser Leu Arg Asn Lys
         355                 360                 365

 gat gtg aaa aat gca ctg aag aag atg act agg gga agg cag tca tcc     1152
 Asp Val Lys Asn Ala Leu Lys Lys Met Thr Arg Gly Arg Gln Ser Ser
     370                 375                 380

 tga                                                                 1155
 






      <210> 206
      <211> 369
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (1)..(369)

      <400> 206
  atg aac cca tca gag atg caa aga aaa gtg cct ccg cag aga cag aaa      48
  Met Asn Pro Ser Glu Met Gln Arg Lys Val Pro Pro Gln Arg Gln Lys
    1               5                  10                  15

 acc tgc aat cga gca tca tcg act cgc cag gtg aac aaa atg gtg ata       96
 Thr Cys Asn Arg Ala Ser Ser Thr Arg Gln Val Asn Lys Met Val Ile
              20                  25                  30

 tca gaa gaa cag atg aag ttg cca tcc aca aag gaa gcg gag ctg ccg      144
 Ser Glu Glu Gln Met Lys Leu Pro Ser Thr Lys Glu Ala Glu Leu Pro
          35                  40                  45

 acc tgg gcc caa cta aag aag ctg aca cag tta gct gaa aaa agc ctg      192
 Thr Trp Ala Gln Leu Lys Lys Leu Thr Gln Leu Ala Glu Lys Ser Leu
      50                  55                  60

 aag aaa aca agg gta aca caa act cca gag aat atg ctg ctt gca gtt      240
 Lys Lys Thr Arg Val Thr Gln Thr Pro Glu Asn Met Leu Leu Ala Val
  65                  70                  75                  80

 ttg atg att gta tct acc gtg gta agt ctc ccc atg tct gca gga gca      288
 Leu Met Ile Val Ser Thr Val Val Ser Leu Pro Met Ser Ala Gly Ala
                  85                  90                  95

 gct gca gct aat tat act tac tgg gcc tat gtg cct ttc ctg ctc tta      336
 Ala Ala Ala Asn Tyr Thr Tyr Trp Ala Tyr Val Pro Phe Leu Leu Leu
             100                 105                 110

 att tgg gca gtc ata tgg atg gat aat cat tga                          369
 Ile Trp Ala Val Ile Trp Met Asp Asn His 
         115                 120





      <210> 207
      <211> 1621
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (46)..(351)

      <400> 207
 cgagcccagc tccgccgccg agcgctgtgc cggcacggct acacc    atg gag cgc      54
                                                      Met Glu Arg
                                                        1

 ccg gat aag gcg gcg ctg aac gca ctg cag cct cct gag ttc aga aat      102
 Pro Asp Lys Ala Ala Leu Asn Ala Leu Gln Pro Pro Glu Phe Arg Asn
       5                  10                  15

 gaa agc tca tta gca tct aca ctg aag acg ctc ctg ttc ttc aca gct      150
 Glu Ser Ser Leu Ala Ser Thr Leu Lys Thr Leu Leu Phe Phe Thr Ala
  20                  25                  30                  35

 tta atg atc act gtt cct att ggg tta tat ttc aca act aaa tct tac      198
 Leu Met Ile Thr Val Pro Ile Gly Leu Tyr Phe Thr Thr Lys Ser Tyr
                  40                  45                  50

 ata ttt gaa ggc gcc ctt ggg atg tcc aat agg gac agc tat ttt tac      246
 Ile Phe Glu Gly Ala Leu Gly Met Ser Asn Arg Asp Ser Tyr Phe Tyr
              55                  60                  65

 gct gct att gtt gca gtg gtc gcc gtc cat gtg gtg ctg gcc ctc ttt      294
 Ala Ala Ile Val Ala Val Val Ala Val His Val Val Leu Ala Leu Phe
          70                  75                  80

 gtg tat gtg gcc tgg aat gaa ggc tca cga cag tgg cgt gaa ggc aaa      342
 Val Tyr Val Ala Trp Asn Glu Gly Ser Arg Gln Trp Arg Glu Gly Lys
      85                  90                  95

 cag gat taa agtgaac atcacctttt tatagcatta aattcatttt ttaaaatgat      398
 Gln Asp 
 100

 aaatgctgga gggggccatc tgatttgaat aaagttgaaa gaacatgtta aagtcagtct    458

 taaggagtca cgtttgagta tgtaaatttt gatctttcta atatgttggt ttgtatattc    518

 agttttaact gtatgaatct gatttgcaaa tgagaatttg gaaaagttaa attagttaca    578

 aagaaatatg ttaatttaat tagacaatac tctggaagga attttatctt ctttcaacaa    638

 aacatgtttt atagtattct gacttacggt tgcttttgag ttttactcat ttggatatat    698

 taagatgcac acagtgaagc aaattaaact ccactttacg ctggaatgct ttctttagca    758

 tgaaaatacc aggtccttgg atttgggatt ttaatttcct atggaaagtt gcttaaattg    818

 tggacactgg aattaatctg aatgtcactg aggaatttca catgaagtgt aatccctagt    878

 caataagaat tatccattac attattttat gggaaaacta ggctaaatta catccattca    938

 ggtaaaagga ccttagctta ctgaaggatc taaagagcaa agcaaagatc tcactactca    998

 aacactcagc ctgcttcctt caagtcccct tgcaggccag ctttgtgctt tgcagaccaa   1058

 ctttttaatg agatactttg cttcctcatt caacattgaa gctaggcttc aattaaaagg   1118

 ttcgaggaag ctccatttaa aattgttttt tttactattt tttaaaattg tagtgtatat   1178

 gataggaatt tgcatttaaa tatgttcatt tttgcatatg ttaggagtgg aaacaatctg   1238

 gaaaacattt ttttttcatc caaaaagtat tctccttggg catatctgat ggaaaaaaac   1298

 cttgatttta ttttcgtatc tttagtctgt gttctttcta gttatttggt actaattatg   1358

 tgcaatctaa aaacactccc acaagtattt gttttttaat tataaaatca tagtatatgt   1418

 tctttgtaga aaactggaaa aatacatatt caaacaggaa aaaaaatcaa aattccccat   1478

 aatgttgcca tctaaaaata acctctattt tagttgatat cccgtattca tttttgaaag   1538

 ccattcctta atgctagttt gatacacact aaaagtttag cttacaagtt caaattctgc   1598

 cagcttttcc tgacagctat ttg                                           1621




      <210> 208
      <211> 5847
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (1)..(4725)

      <400> 208
  atg gtg gaa gca aag ggc aaa gct agg aaa cca cat ggt ccg tgg gga      48
  Met Val Glu Ala Lys Gly Lys Ala Arg Lys Pro His Gly Pro Trp Gly
    1               5                  10                  15

 agg tgt aca gga gac tgt ggt ccc gga gga gtc cag agt cgg gca gtg       96
 Arg Cys Thr Gly Asp Cys Gly Pro Gly Gly Val Gln Ser Arg Ala Val
              20                  25                  30

 tgg tgt ttt cat gtt gac ggg tgg aca agt cac ctg tct aac tgt ggt      144
 Trp Cys Phe His Val Asp Gly Trp Thr Ser His Leu Ser Asn Cys Gly
          35                  40                  45

 gag agc aac agg cct cca aag gaa aga agt tgt ttc cga gtt tgt gac      192
 Glu Ser Asn Arg Pro Pro Lys Glu Arg Ser Cys Phe Arg Val Cys Asp
      50                  55                  60

 tgg cac agt gac ctc ttt cag tgg gag gtt tct gac tgg cac cac tgt      240
 Trp His Ser Asp Leu Phe Gln Trp Glu Val Ser Asp Trp His His Cys
  65                  70                  75                  80

 gtg ctt gtt cct tac gct cgc ggt gaa gtc aag cct cgg act gca gag      288
 Val Leu Val Pro Tyr Ala Arg Gly Glu Val Lys Pro Arg Thr Ala Glu
                  85                  90                  95

 tgt gtg acg gct cag cat gga ctg cag cac cgg atg gtg cgc tgc att      336
 Cys Val Thr Ala Gln His Gly Leu Gln His Arg Met Val Arg Cys Ile
             100                 105                 110

 cag aag ctg aac cga act gtg gtt gca aat gaa ata tgc gaa cac ttt      384
 Gln Lys Leu Asn Arg Thr Val Val Ala Asn Glu Ile Cys Glu His Phe
         115                 120                 125

 gcc ctt cag cct cct aca gaa cag gct tgc ctc att cct tgt ccc cgg      432
 Ala Leu Gln Pro Pro Thr Glu Gln Ala Cys Leu Ile Pro Cys Pro Arg
     130                 135                 140

 gat tgt gta gta tct gag ttc tta cca tgg tcc aac tgt agc aag gga      480
 Asp Cys Val Val Ser Glu Phe Leu Pro Trp Ser Asn Cys Ser Lys Gly
 145                 150                 155                 160

 tgt ggg aag aaa ttg cag cat aga act cgc gcg gtc ata gct ccc cct      528
 Cys Gly Lys Lys Leu Gln His Arg Thr Arg Ala Val Ile Ala Pro Pro
                 165                 170                 175

 ctc ttt ggt ggt ttg caa tgt cca aat ctg act gag tca aga gcc tgt      576
 Leu Phe Gly Gly Leu Gln Cys Pro Asn Leu Thr Glu Ser Arg Ala Cys
             180                 185                 190

 gat gct ccc att tcc tgt cct ctt ggg gaa gag gaa tat aca ttt agc      624
 Asp Ala Pro Ile Ser Cys Pro Leu Gly Glu Glu Glu Tyr Thr Phe Ser
         195                 200                 205

 ctt aag gtt gga cca tgg agt aaa tgc aga ctg cct cat ctt aaa gaa      672
 Leu Lys Val Gly Pro Trp Ser Lys Cys Arg Leu Pro His Leu Lys Glu
     210                 215                 220

 att aat cca agc gga aga act gtt ctg gat ttt aac tct gat tca aat      720
 Ile Asn Pro Ser Gly Arg Thr Val Leu Asp Phe Asn Ser Asp Ser Asn
 225                 230                 235                 240

 gag cga gtc acc ttt aaa cat caa agt tac aaa gca cat cat cat tcg      768
 Glu Arg Val Thr Phe Lys His Gln Ser Tyr Lys Ala His His His Ser
                 245                 250                 255

 aag tct tgg gca ata gag ata ggt tat caa acc cgg cag gtt tcg tgt      816
 Lys Ser Trp Ala Ile Glu Ile Gly Tyr Gln Thr Arg Gln Val Ser Cys
             260                 265                 270

 aca aga agt gat gga caa aat gct atg tta agc ctt tgc ctt caa gat      864
 Thr Arg Ser Asp Gly Gln Asn Ala Met Leu Ser Leu Cys Leu Gln Asp
         275                 280                 285

 tcc ttc cca ttg act gtt cag tcc tgc atc atg ccc aaa gac tgt gaa      912
 Ser Phe Pro Leu Thr Val Gln Ser Cys Ile Met Pro Lys Asp Cys Glu
     290                 295                 300

 acc tcc cag tgg tcc tcc tgg agc ccc tgc tcc aag aca tgc cgt tca      960
 Thr Ser Gln Trp Ser Ser Trp Ser Pro Cys Ser Lys Thr Cys Arg Ser
 305                 310                 315                 320

 ggg agt ctc ttg cca gga ttt agg agc agg agc cgg aac gtg aag cac     1008
 Gly Ser Leu Leu Pro Gly Phe Arg Ser Arg Ser Arg Asn Val Lys His
                 325                 330                 335

 atg gct att gga ggt gga aag gag tgt cct gaa ctt ctt gag aaa gag     1056
 Met Ala Ile Gly Gly Gly Lys Glu Cys Pro Glu Leu Leu Glu Lys Glu
             340                 345                 350

 gcc tgc att gtt gaa gga gaa ctt ctg cag caa tgt ccc agg tat tcc     1104
 Ala Cys Ile Val Glu Gly Glu Leu Leu Gln Gln Cys Pro Arg Tyr Ser
         355                 360                 365

 tgg aga act tct gaa tgg aaa gaa tgc caa gtc tct ctc ctc ctc gag     1152
 Trp Arg Thr Ser Glu Trp Lys Glu Cys Gln Val Ser Leu Leu Leu Glu
     370                 375                 380

 cag cag gat ccc cac tgg cat gtg acg gga ccc gtg tgt ggc ggt ggg     1200
 Gln Gln Asp Pro His Trp His Val Thr Gly Pro Val Cys Gly Gly Gly
 385                 390                 395                 400

 atc cag acc cgg gag gtg tac tgt gcc cag agc gta cca gca gct gcc     1248
 Ile Gln Thr Arg Glu Val Tyr Cys Ala Gln Ser Val Pro Ala Ala Ala
                 405                 410                 415

 gca ctg agg gcc aag gaa gtc tct aga cct gtg gaa aag gca tta tgt     1296
 Ala Leu Arg Ala Lys Glu Val Ser Arg Pro Val Glu Lys Ala Leu Cys
             420                 425                 430

 gtg gga ccc gcc ccg ttg ccc tct cag ctc tgc aat atc cct tgc tct     1344
 Val Gly Pro Ala Pro Leu Pro Ser Gln Leu Cys Asn Ile Pro Cys Ser
         435                 440                 445

 acg gac tgc ata gta tct tcc tgg tca gcc tgg ggc ctg tgc atc cat     1392
 Thr Asp Cys Ile Val Ser Ser Trp Ser Ala Trp Gly Leu Cys Ile His
     450                 455                 460

 gaa aac tgt cat gaa cct cag ggg aaa aaa gga ttt aga acg agg cag     1440
 Glu Asn Cys His Glu Pro Gln Gly Lys Lys Gly Phe Arg Thr Arg Gln
 465                 470                 475                 480

 cgc cat gtc ctc atg gaa tct aca ggg cct gca ggg cat tgc cct cat     1488
 Arg His Val Leu Met Glu Ser Thr Gly Pro Ala Gly His Cys Pro His
                 485                 490                 495

 ttg gtg gag tct gtt cct tgt gag gat cca atg tgc tac cga tgg ctg     1536
 Leu Val Glu Ser Val Pro Cys Glu Asp Pro Met Cys Tyr Arg Trp Leu
             500                 505                 510

 gca tca gaa ggg atc tgt ttc cct gat cat gga aaa tgt ggc ctg gga     1584
 Ala Ser Glu Gly Ile Cys Phe Pro Asp His Gly Lys Cys Gly Leu Gly
         515                 520                 525

 cat cgt att ctg aag gcc gtc tgc cag aat gac cgc gga gaa gat gta     1632
 His Arg Ile Leu Lys Ala Val Cys Gln Asn Asp Arg Gly Glu Asp Val
     530                 535                 540

 tca ggg agt ctt tgc cca gtt ccc cct cct cct gag agg aag tct tgt     1680
 Ser Gly Ser Leu Cys Pro Val Pro Pro Pro Pro Glu Arg Lys Ser Cys
 545                 550                 555                 560

 gaa att ccc tgc cga atg gac tgt gtg ctg agc gag tgg acg gag tgg     1728
 Glu Ile Pro Cys Arg Met Asp Cys Val Leu Ser Glu Trp Thr Glu Trp
                 565                 570                 575

 tca tcc tgt tcc cag tcc tgt tca aat aaa aac tca gat ggg aaa cag     1776
 Ser Ser Cys Ser Gln Ser Cys Ser Asn Lys Asn Ser Asp Gly Lys Gln
             580                 585                 590

 acc agg tca aga act atc ctg gca ctg gct ggg gaa ggt gga aag cca     1824
 Thr Arg Ser Arg Thr Ile Leu Ala Leu Ala Gly Glu Gly Gly Lys Pro
         595                 600                 605

 tgt ccc cct agt cag gct ctc caa gag cat cgt ttg tgt aat gac cat     1872
 Cys Pro Pro Ser Gln Ala Leu Gln Glu His Arg Leu Cys Asn Asp His
     610                 615                 620

 tcc tgt atg cag ctt cac tgg gag aca tcg cct tgg ggc cct tgt tct     1920
 Ser Cys Met Gln Leu His Trp Glu Thr Ser Pro Trp Gly Pro Cys Ser
 625                 630                 635                 640

 gag gac aca ttg gta act gcc ctt aat gca acc att ggc tgg aat gga     1968
 Glu Asp Thr Leu Val Thr Ala Leu Asn Ala Thr Ile Gly Trp Asn Gly
                 645                 650                 655

 gaa gcc acg tgt ggt gta ggc att cag act cgg aga gtc ttc tgt gtc     2016
 Glu Ala Thr Cys Gly Val Gly Ile Gln Thr Arg Arg Val Phe Cys Val
             660                 665                 670

 aag agt cac gtg gga caa gta atg acc aaa aga tgt cca gat tct act     2064
 Lys Ser His Val Gly Gln Val Met Thr Lys Arg Cys Pro Asp Ser Thr
         675                 680                 685

 cga cct gaa act gtg cgc ccc tgt ttt ctc cca tgc aaa aaa gac tgt     2112
 Arg Pro Glu Thr Val Arg Pro Cys Phe Leu Pro Cys Lys Lys Asp Cys
     690                 695                 700

 att gtg act gct ttc agt gag tgg aca ccc tgc cca agg atg tgc caa     2160
 Ile Val Thr Ala Phe Ser Glu Trp Thr Pro Cys Pro Arg Met Cys Gln
 705                 710                 715                 720

 gca gga aat gcc aca gta aaa cag tct cga tac aga atc atc atc caa     2208
 Ala Gly Asn Ala Thr Val Lys Gln Ser Arg Tyr Arg Ile Ile Ile Gln
                 725                 730                 735

 gaa gca gcc aat gga ggc cag gaa tgc cca gat acc tta tat gag gag     2256
 Glu Ala Ala Asn Gly Gly Gln Glu Cys Pro Asp Thr Leu Tyr Glu Glu
             740                 745                 750

 aga gag tgt gaa gat gtt tcc ttg tgt cct gta tat cgg tgg aag cca     2304
 Arg Glu Cys Glu Asp Val Ser Leu Cys Pro Val Tyr Arg Trp Lys Pro
         755                 760                 765

 cag aaa tgg agc cct tgc atc tta gtg cca gag tct gtc tgg cag gga     2352
 Gln Lys Trp Ser Pro Cys Ile Leu Val Pro Glu Ser Val Trp Gln Gly
     770                 775                 780

 ata acg ggc agc agt gaa gcc tgt gga aag ggg tta caa aca aga gct     2400
 Ile Thr Gly Ser Ser Glu Ala Cys Gly Lys Gly Leu Gln Thr Arg Ala
 785                 790                 795                 800

 gtc tca tgc atc tct gat gac aac cgg tca gca gaa atg atg gaa tgc     2448
 Val Ser Cys Ile Ser Asp Asp Asn Arg Ser Ala Glu Met Met Glu Cys
                 805                 810                 815

 ctc aag cag aca aac ggc atg cct ctc ctt gtg caa gaa tgc aca gtc     2496
 Leu Lys Gln Thr Asn Gly Met Pro Leu Leu Val Gln Glu Cys Thr Val
             820                 825                 830

 cca tgt cga gaa gac tgc acc ttc act gct tgg tcc aag ttt acg ccc     2544
 Pro Cys Arg Glu Asp Cys Thr Phe Thr Ala Trp Ser Lys Phe Thr Pro
         835                 840                 845

 tgc tcc acg aac tgt gaa gcc aca aaa agt agg cgg cga cag ctc aca     2592
 Cys Ser Thr Asn Cys Glu Ala Thr Lys Ser Arg Arg Arg Gln Leu Thr
     850                 855                 860

 ggg aaa agc aga aag aag gag aaa tgc cag gat tct gac ctt tac cct     2640
 Gly Lys Ser Arg Lys Lys Glu Lys Cys Gln Asp Ser Asp Leu Tyr Pro
 865                 870                 875                 880

 cta gtg gag aca gaa cta tgt cct tgt gat gaa ttt ata tcc caa cct     2688
 Leu Val Glu Thr Glu Leu Cys Pro Cys Asp Glu Phe Ile Ser Gln Pro
                 885                 890                 895

 tat gga aac tgg tca gat tgc att ctt cca gaa ggc aga agg gag cct     2736
 Tyr Gly Asn Trp Ser Asp Cys Ile Leu Pro Glu Gly Arg Arg Glu Pro
             900                 905                 910

 cac cga gga ctg cgg gta caa gca gac agc aaa gaa tgt gga gaa ggc     2784
 His Arg Gly Leu Arg Val Gln Ala Asp Ser Lys Glu Cys Gly Glu Gly
         915                 920                 925

 ctg cgc ttt cga gca gta gcc tgt tct gat aaa aat gga aga cct gtt     2832
 Leu Arg Phe Arg Ala Val Ala Cys Ser Asp Lys Asn Gly Arg Pro Val
     930                 935                 940

 gac ccc tcc ttc tgc agc agc tct ggt tac att caa gaa aaa tgt gtc     2880
 Asp Pro Ser Phe Cys Ser Ser Ser Gly Tyr Ile Gln Glu Lys Cys Val
 945                 950                 955                 960

 att ccc tgc cca ttt gat tgc aag tta agc gat tgg tct agt tgg ggg     2928
 Ile Pro Cys Pro Phe Asp Cys Lys Leu Ser Asp Trp Ser Ser Trp Gly
                 965                 970                 975

 tct tgc agt tca tct tgt gga att gga gtg aga att cga tcc aaa tgg     2976
 Ser Cys Ser Ser Ser Cys Gly Ile Gly Val Arg Ile Arg Ser Lys Trp
             980                 985                 990

 cta aaa gaa aaa cct tac aat gga gga cga cca tgt ccc aaa ctg gat     3024
 Leu Lys Glu Lys Pro Tyr Asn Gly Gly Arg Pro Cys Pro Lys Leu Asp
         995                1000                1005

 ctc aag aat cag gct cag gta cat gag gca gtc cca tgt tac agt gag     3072
 Leu Lys Asn Gln Ala Gln Val His Glu Ala Val Pro Cys Tyr Ser Glu
    1010                1015                1020

 tgc aat cag tat tcc tgg gtt gta gaa cac tgg tct tca tgc aaa atc     3120
 Cys Asn Gln Tyr Ser Trp Val Val Glu His Trp Ser Ser Cys Lys Ile
1025                1030                1035                1040

 aac aat gag ctg agg tcc ctg cgc tgt gga gga gga aca caa tct agg     3168
 Asn Asn Glu Leu Arg Ser Leu Arg Cys Gly Gly Gly Thr Gln Ser Arg
                1045                1050                1055

 aaa atc aga tgt gtg aat act gcg gat ggt gaa ggt gga gca gtg gat     3216
 Lys Ile Arg Cys Val Asn Thr Ala Asp Gly Glu Gly Gly Ala Val Asp
            1060                1065                1070

 agc aac ctg tgc aac cag gat gaa att ccc cca gaa acc cag tcc tgt     3264
 Ser Asn Leu Cys Asn Gln Asp Glu Ile Pro Pro Glu Thr Gln Ser Cys
        1075                1080                1085

 tct ctt atg tgt ccc aat gag tgt gtc atg tct gag tgg gga ctt tgg     3312
 Ser Leu Met Cys Pro Asn Glu Cys Val Met Ser Glu Trp Gly Leu Trp
    1090                1095                1100

 agc aaa tgc cca cag tca tgc gat ccc cac aca atg cag aga aga act     3360
 Ser Lys Cys Pro Gln Ser Cys Asp Pro His Thr Met Gln Arg Arg Thr
1105                1110                1115                1120

 cgc cac ctg cta aga cca tca ctg aac tca agg act tgt gct gaa gac     3408
 Arg His Leu Leu Arg Pro Ser Leu Asn Ser Arg Thr Cys Ala Glu Asp
                1125                1130                1135

 tca cag gtg cag cct tgc ctc ctg aat gaa aat tgc ttc cag ttc cag     3456
 Ser Gln Val Gln Pro Cys Leu Leu Asn Glu Asn Cys Phe Gln Phe Gln
            1140                1145                1150

 tac aat cta aca gag tgg agc aca tgc cag ctg agt gaa aac gca ccc     3504
 Tyr Asn Leu Thr Glu Trp Ser Thr Cys Gln Leu Ser Glu Asn Ala Pro
        1155                1160                1165

 tgt ggt caa ggc gtc agg acc cgc ctg cta agc tgt gtg tgc agt gat     3552
 Cys Gly Gln Gly Val Arg Thr Arg Leu Leu Ser Cys Val Cys Ser Asp
    1170                1175                1180

 ggc aag cca gtc agc atg gac caa tgt gag cag cat aat ttg gag aag     3600
 Gly Lys Pro Val Ser Met Asp Gln Cys Glu Gln His Asn Leu Glu Lys
1185                1190                1195                1200

 ccc cag aga atg agc att ccc tgc ttg gtg gaa tgc gtg gtc aac tgt     3648
 Pro Gln Arg Met Ser Ile Pro Cys Leu Val Glu Cys Val Val Asn Cys
                1205                1210                1215

 cag ctc tca ggg tgg acg gct tgg aca gag tgt tca cag acc tgt ggc     3696
 Gln Leu Ser Gly Trp Thr Ala Trp Thr Glu Cys Ser Gln Thr Cys Gly
            1220                1225                1230

 cat gga ggt cga atg agc cgg act cga ttt atc att atg cca acc caa     3744
 His Gly Gly Arg Met Ser Arg Thr Arg Phe Ile Ile Met Pro Thr Gln
        1235                1240                1245

 gga gaa gga cgg cca tgc ccc aca gag ctt acc cag gag aaa acc tgc     3792
 Gly Glu Gly Arg Pro Cys Pro Thr Glu Leu Thr Gln Glu Lys Thr Cys
    1250                1255                1260

 cca gtg acc ccc tgc tac agc tgg gtc ctt ggc aac tgg tct gca tgt     3840
 Pro Val Thr Pro Cys Tyr Ser Trp Val Leu Gly Asn Trp Ser Ala Cys
1265                1270                1275                1280

 aaa ttg gag ggt gga gac tgt ggg gaa gga gtt cag atc cgc agc ctt     3888
 Lys Leu Glu Gly Gly Asp Cys Gly Glu Gly Val Gln Ile Arg Ser Leu
                1285                1290                1295

 tcc tgc atg gtc cac agt ggt tca ata tct cat gca gct gga cgt gtc     3936
 Ser Cys Met Val His Ser Gly Ser Ile Ser His Ala Ala Gly Arg Val
            1300                1305                1310

 gag gat gca ctg tgt gga gaa atg ccc ttt cag gac agc atc ctg aag     3984
 Glu Asp Ala Leu Cys Gly Glu Met Pro Phe Gln Asp Ser Ile Leu Lys
        1315                1320                1325

 cag ctg tgt tct gtg cct tgc cca gga gac tgc cat tta aca gaa tgg     4032
 Gln Leu Cys Ser Val Pro Cys Pro Gly Asp Cys His Leu Thr Glu Trp
    1330                1335                1340

 tca gag tgg agc aca tgt gaa tta acc tgc att gat gga aga agc ttt     4080
 Ser Glu Trp Ser Thr Cys Glu Leu Thr Cys Ile Asp Gly Arg Ser Phe
1345                1350                1355                1360

 gag act gtg ggc cgc cag tct aga tca agg act ttt ata att cag tct     4128
 Glu Thr Val Gly Arg Gln Ser Arg Ser Arg Thr Phe Ile Ile Gln Ser
                1365                1370                1375

 ttt gag aac caa gac agc tgc ccc caa cag gtt cta gaa aca cgc cct     4176
 Phe Glu Asn Gln Asp Ser Cys Pro Gln Gln Val Leu Glu Thr Arg Pro
            1380                1385                1390

 tgt aca gga ggc aaa tgt tat cac tac aca tgg aaa gca agt ctt tgg     4224
 Cys Thr Gly Gly Lys Cys Tyr His Tyr Thr Trp Lys Ala Ser Leu Trp
        1395                1400                1405

 aac aat aac gaa cga act gta tgg tgc cag cgt tca gat ggc gtt aat     4272
 Asn Asn Asn Glu Arg Thr Val Trp Cys Gln Arg Ser Asp Gly Val Asn
    1410                1415                1420

 gtc aca gga ggc tgc tcc cct cag gcc cgt cct gct gcc att cgg cag     4320
 Val Thr Gly Gly Cys Ser Pro Gln Ala Arg Pro Ala Ala Ile Arg Gln
1425                1430                1435                1440

 tgc att cca gcc tgc aga aaa cct ttc tcc tac tgt aca cag ggt gga     4368
 Cys Ile Pro Ala Cys Arg Lys Pro Phe Ser Tyr Cys Thr Gln Gly Gly
                1445                1450                1455

 gtc tgt ggt tgt gag aag ggc tat aca gag ata atg aga tca aat ggt     4416
 Val Cys Gly Cys Glu Lys Gly Tyr Thr Glu Ile Met Arg Ser Asn Gly
            1460                1465                1470

 ttc ctg gat tac tgc atg aaa gta cca ggc tca gag gat aaa aaa gct     4464
 Phe Leu Asp Tyr Cys Met Lys Val Pro Gly Ser Glu Asp Lys Lys Ala
        1475                1480                1485

 gat gtg aaa aac ctt tct ggg aaa aac aga cct gtg aat tca aaa ata     4512
 Asp Val Lys Asn Leu Ser Gly Lys Asn Arg Pro Val Asn Ser Lys Ile
    1490                1495                1500

 cat gat att ttt aaa gga tgg tct ctt caa cca ctt gat cca gat ggc     4560
 His Asp Ile Phe Lys Gly Trp Ser Leu Gln Pro Leu Asp Pro Asp Gly
1505                1510                1515                1520

 cga gta aaa att tgg gtt tat ggc gtt tca ggt ggc gct ttt ctc atc     4608
 Arg Val Lys Ile Trp Val Tyr Gly Val Ser Gly Gly Ala Phe Leu Ile
                1525                1530                1535

 atg att ttc cta ata ttt act tcc tac ctt gtt tgc aag aag cca aaa     4656
 Met Ile Phe Leu Ile Phe Thr Ser Tyr Leu Val Cys Lys Lys Pro Lys
            1540                1545                1550

 cca cat caa agc aca cct ccc caa cag aag cct ctg acc tta gcc tac     4704
 Pro His Gln Ser Thr Pro Pro Gln Gln Lys Pro Leu Thr Leu Ala Tyr
        1555                1560                1565

 gat gga gac tta gac atg taa tc tgaaaaagaa atccaaatgt agacatcaac     4757
 Asp Gly Asp Leu Asp Met 
    1570

 tgccttaacc gctttctctt ttgtagctct cagacttctc agttttttga ggaatctcaa   4817

 gatgtgatat attgggcaga atacaaatat tgcaaaagta atattgcctc aacttcattt   4877

 ggacatggag tcaaggatta ttaggtctgc cattttgttt tcaagttgtt tgtgggtgtg   4937

 ttttattttt ttggttttcc caagggacct gaaaaccctt ctcttcctgt ttggaactgg   4997

 gaggaagaaa acatgatgga attcccacag acttgagtaa acttgatctt cagcagcata   5057

 atgacaatcc agaggaaaat acagtcaagg catttactct aaatgacgag tctgacactg   5117

 cattgttacg cactatatta gtgcaaagtc tttattcttc ccatacttca acactgagtt   5177

 ttctagagtt tactttggtt taaagacttt caaatcggat tgcctatttt tcatgaacac   5237

 agagagaatg gattaccatt tcagaaattc tctgagtttt taacctttaa atattgtatt   5297

 ttgttttgta gccaggggat gatggcgctt catgggttgc agctactgaa aatagcagcg   5357

 tgtgtgtaat tgctggacta gatgaaagct aggtcatttc tgaagggaat gtgtactgaa   5417

 tgttagagtg tacaaatgaa atatgtggtt aaattggaga atgaggtaga ttatttgatt   5477

 actaaaactg tattttaaca aaaacttatc catgtagata tagcattaac cacacacagt   5537

 tgtaattcag tttaatgatg acaaactctg cttttgtaat ttcaattttc ttatctgaat   5597

 atttataaat tcttctttca aatttaatta tctgacctca tttaatatac atcaaacacc   5657

 gatcctgttt gtacaaagtc ttgcttttat aaggtttcaa taatatctaa aacaacacat   5717

 taaaaagctg agaccatttt atgaagataa ttgtttgtaa tcataggtgt tgaaagtaaa   5777

 aaggtgccat cttgtggtat tgacttgtat ttataacaaa taaactgctc aagagacaaa   5837

 aaaaaaaaaa                                                          5847




      <210> 209
      <211> 1231
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (194)..(1231)

      <400> 209
 ctgtcttctt ctttgccttc caagacacca agctgttccc acccaaggtc ctggcactta     60

 ctctccctgc acctcacacc agccccacat cttcccaagg ccagctgctc cccatcacct    120

 gggtctcctc caaaacccgc acaatgctgc atcctgcatc cagtgcctat atcccgctgg    180

 ggtggccacc acc   atg ccc aag aga aag gct gaa ggg gat gct aag gga     229
                  Met Pro Lys Arg Lys Ala Glu Gly Asp Ala Lys Gly
                    1               5                  10

 gat aaa gca aag gtg aag gac gaa cca cag aga aga tcc gcg agg ttg      277
 Asp Lys Ala Lys Val Lys Asp Glu Pro Gln Arg Arg Ser Ala Arg Leu
          15                  20                  25

 tct gct aaa cct gct cct cca aag cca gag ccc aag cct aaa aag gcc      325
 Ser Ala Lys Pro Ala Pro Pro Lys Pro Glu Pro Lys Pro Lys Lys Ala
      30                  35                  40

 cct gca aag aag gcc aaa ggg aaa aag gga aaa gct gat gct ggc aag      373
 Pro Ala Lys Lys Ala Lys Gly Lys Lys Gly Lys Ala Asp Ala Gly Lys
  45                  50                  55                  60

 gag ggg aat aac cct gca gaa aat gga gat gcc aaa aca gac cag gca      421
 Glu Gly Asn Asn Pro Ala Glu Asn Gly Asp Ala Lys Thr Asp Gln Ala
                  65                  70                  75

 cag aaa gct gaa ggt gct gga gat gcc aaa agt cct gag gaa gaa agt      469
 Gln Lys Ala Glu Gly Ala Gly Asp Ala Lys Ser Pro Glu Glu Glu Ser
              80                  85                  90

 acc tca aat gaa cag gga ggg cat cat cag tca cag agc agc ctg ggc      517
 Thr Ser Asn Glu Gln Gly Gly His His Gln Ser Gln Ser Ser Leu Gly
          95                 100                 105

 aac acc aag acc aga cag aaa ccc ttt cca agc aac aga gtg gaa aca      565
 Asn Thr Lys Thr Arg Gln Lys Pro Phe Pro Ser Asn Arg Val Glu Thr
     110                 115                 120

 cca aca aac cct ttt cat gag aca cac att tct gca aga cct atc ttg      613
 Pro Thr Asn Pro Phe His Glu Thr His Ile Ser Ala Arg Pro Ile Leu
 125                 130                 135                 140

 aca gaa gcc acc agg tcc caa aca tgt cac atg tat gaa aaa ttc aaa      661
 Thr Glu Ala Thr Arg Ser Gln Thr Cys His Met Tyr Glu Lys Phe Lys
                 145                 150                 155

 ttc aaa cgt gga gaa gag cag ttt tat ggg acc cgc ctt cag gtg atg      709
 Phe Lys Arg Gly Glu Glu Gln Phe Tyr Gly Thr Arg Leu Gln Val Met
             160                 165                 170

 gat aca aag ttt aga gaa aat gaa gag cta gaa agg tgc agt gcc atg      757
 Asp Thr Lys Phe Arg Glu Asn Glu Glu Leu Glu Arg Cys Ser Ala Met
         175                 180                 185

 act caa aat ggg cct tct aat cac acc aag tct aac aca cag caa cta      805
 Thr Gln Asn Gly Pro Ser Asn His Thr Lys Ser Asn Thr Gln Gln Leu
     190                 195                 200

 gag acc cct agc ccc caa ttt tca gtg ttt ttc tta gat tgg ttt ttg      853
 Glu Thr Pro Ser Pro Gln Phe Ser Val Phe Phe Leu Asp Trp Phe Leu
 205                 210                 215                 220

 att cac gct tct caa att tgt aaa atc ata agg aga ata aaa tac atc      901
 Ile His Ala Ser Gln Ile Cys Lys Ile Ile Arg Arg Ile Lys Tyr Ile
                 225                 230                 235

 tta aaa act aaa agt aag aaa gtt ata aag aag gat tca gca gca tca      949
 Leu Lys Thr Lys Ser Lys Lys Val Ile Lys Lys Asp Ser Ala Ala Ser
             240                 245                 250

 gaa gag atc tta aat gtg cag agg gaa aaa ctg tca gtc aga cag ccc      997
 Glu Glu Ile Leu Asn Val Gln Arg Glu Lys Leu Ser Val Arg Gln Pro
         255                 260                 265

 atg agc cgt cct tgg tat gtc agt att ttt ttt tta gga gat gag gaa     1045
 Met Ser Arg Pro Trp Tyr Val Ser Ile Phe Phe Leu Gly Asp Glu Glu
     270                 275                 280

 gcc agt cca gta tct aag aac ttg ctc aag gtc aca ctg cca gaa ggt     1093
 Ala Ser Pro Val Ser Lys Asn Leu Leu Lys Val Thr Leu Pro Glu Gly
 285                 290                 295                 300

 ggc aga gca agt tgg tgt gac acc ctt att ggt acc caa gcc ata ccg     1141
 Gly Arg Ala Ser Trp Cys Asp Thr Leu Ile Gly Thr Gln Ala Ile Pro
                 305                 310                 315

 gtt ctt ata gct ccc cag aat caa gcc ctc ttc gtt ctg gca tgt gga     1189
 Val Leu Ile Ala Pro Gln Asn Gln Ala Leu Phe Val Leu Ala Cys Gly
             320                 325                 330

 gaa gct cca ccc tat ttc cct aaa gga aat cct gcc aac tga             1231
 Glu Ala Pro Pro Tyr Phe Pro Lys Gly Asn Pro Ala Asn 
         335                 340                 345





      <210> 210
      <211> 753
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (206)..(559)

      <400> 210
 agcgctgagc atacaaaggc taagaagggc agatctgatc tgatctgagc caagaagcga     60

 tggctcctaa gaaaataacc taccagcatc tcagaaactc cctttgtctt cccatgtttg    120

 aggttctacc caggaagcag gcaccaaatg gaaatatctg aaaccatccc agcaacccaa    180

 ccacagctgg ttctccctgg agacc  atg aac cac act gtc caa acc ctc ttc     232
                              Met Asn His Thr Val Gln Thr Leu Phe
                                1               5

 act cct gcc aac acc ggc cgc tcc acc aac cat gag atg ctc aag gag      280
 Thr Pro Ala Asn Thr Gly Arg Ser Thr Asn His Glu Met Leu Lys Glu
  10                  15                  20                  25

 aag cat gag gtg gct gtg ctg ggg gca ccc cac aac cct gtg cct cca      328
 Lys His Glu Val Ala Val Leu Gly Ala Pro His Asn Pro Val Pro Pro
                  30                  35                  40

 gcg ttc acc atg atc cac atc tgc agt gag acc tcc gtg ccc gac cat      376
 Ala Phe Thr Met Ile His Ile Cys Ser Glu Thr Ser Val Pro Asp His
              45                  50                  55

 gtc gtc tgg tcc cta ttc aac acc ctc ttc aag aat tcc tgc tgc ccg      424
 Val Val Trp Ser Leu Phe Asn Thr Leu Phe Lys Asn Ser Cys Cys Pro
          60                  65                  70

 gac ttc ata gca ttc atc tac tct gcc tgt gtc tcc acc gcc aag tgc      472
 Asp Phe Ile Ala Phe Ile Tyr Ser Ala Cys Val Ser Thr Ala Lys Cys
      75                  80                  85

 ctg aac atc tgg gcc ctg att ttg ggc atc ctc atg acc att ctg ctc      520
 Leu Asn Ile Trp Ala Leu Ile Leu Gly Ile Leu Met Thr Ile Leu Leu
  90                  95                 100                 105

 atc atc atc cca gtg ttg gtc gtc cag gcc cag cga tag atcaggaggc       569
 Ile Ile Ile Pro Val Leu Val Val Gln Ala Gln Arg 
                 110                 115

 atcattgagg ccaggagctc tgcccgtgac ctgtatccca cgtactctat cttccattcc    629

 tcgccctgcc cccagagggc caggagctct ggccttggac tgtaatccac tttattcaac    689

 ttccaatcct cggcctgttc ccaaagccga gttctggatt agccctttat cctcaaacgc    749

 tttt                                                                 753




      <210> 211
      <211> 2494
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (181)..(1989)

      <400> 211
 aggcctgagc cggtgtgcgc cacctgggct gcggcggcga cagcgacttc tcctgacccc     60

 tctgccaccc tcccatccgt ccgcgggtcc gtggagctgg agcagatccc ccagccggct    120

 gagacaggtt gtcttttgga aatgcaggtt taaggacaaa ttatctgctt aagctagaag    180
                                                                 
 atg gga tcg aat agc agc aga atc ggc gat ctt cct aaa aat gag tac      228
 Met Gly Ser Asn Ser Ser Arg Ile Gly Asp Leu Pro Lys Asn Glu Tyr
   1               5                  10                  15

 ttg aaa aag tta tca ggc acg gaa tct atc tct gag aat gac ccg ttc      276
 Leu Lys Lys Leu Ser Gly Thr Glu Ser Ile Ser Glu Asn Asp Pro Phe
              20                  25                  30

 tgg aat cag ctt ctc tca ttt tct ttc cct gca cca act agc agt agt      324
 Trp Asn Gln Leu Leu Ser Phe Ser Phe Pro Ala Pro Thr Ser Ser Ser
          35                  40                  45

 gag ttg aaa ctc ttg gag gaa gca acc att tca gtc tgc agg tca tta      372
 Glu Leu Lys Leu Leu Glu Glu Ala Thr Ile Ser Val Cys Arg Ser Leu
      50                  55                  60

 gtt gaa aac aat cct cga aca gga aat ctt ggt gca cta att aag gtc      420
 Val Glu Asn Asn Pro Arg Thr Gly Asn Leu Gly Ala Leu Ile Lys Val
  65                  70                  75                  80

 ttc ctt tct aga acc aaa gaa cta aaa ctt tca gca gaa tgt cag aac      468
 Phe Leu Ser Arg Thr Lys Glu Leu Lys Leu Ser Ala Glu Cys Gln Asn
                  85                  90                  95

 cac atc ttc att tgg cag aca cac aat gct ttg ttt att att tgc tgt      516
 His Ile Phe Ile Trp Gln Thr His Asn Ala Leu Phe Ile Ile Cys Cys
             100                 105                 110

 ttg ctg aaa gtg ttc atc tgt cag atg tca gag gag gaa tta caa ctt      564
 Leu Leu Lys Val Phe Ile Cys Gln Met Ser Glu Glu Glu Leu Gln Leu
         115                 120                 125

 cat ttt act tat gaa gaa aaa tct cct ggc aat tac agt tct gac tca      612
 His Phe Thr Tyr Glu Glu Lys Ser Pro Gly Asn Tyr Ser Ser Asp Ser
     130                 135                 140

 gaa gat ctt ttg gaa gaa ttg ctg tgc tgt ttg atg cag ttg atc act      660
 Glu Asp Leu Leu Glu Glu Leu Leu Cys Cys Leu Met Gln Leu Ile Thr
 145                 150                 155                 160

 gat att cca ctc tta gat att aca tat gaa ata tca gta gaa gct ata      708
 Asp Ile Pro Leu Leu Asp Ile Thr Tyr Glu Ile Ser Val Glu Ala Ile
                 165                 170                 175

 tca aca atg gtt gtt ttc ctt tcc tgc caa ctc ttc cac aaa gaa gtt      756
 Ser Thr Met Val Val Phe Leu Ser Cys Gln Leu Phe His Lys Glu Val
             180                 185                 190

 ttg cga cag agc atc agc cac aag tat ttg atg cga ggt cca tgt ctt      804
 Leu Arg Gln Ser Ile Ser His Lys Tyr Leu Met Arg Gly Pro Cys Leu
         195                 200                 205

 cca tac acc agc aaa ctt gtg aag acc tta tta tat aac ttt atc aga      852
 Pro Tyr Thr Ser Lys Leu Val Lys Thr Leu Leu Tyr Asn Phe Ile Arg
     210                 215                 220

 caa gaa aag cca cct cct cca ggg gcc cat gtt ttc cct cag cag tcg      900
 Gln Glu Lys Pro Pro Pro Pro Gly Ala His Val Phe Pro Gln Gln Ser
 225                 230                 235                 240

 gat ggg gga gga ctg ctt tat gga ctt gca tca gga gta gca aca gga      948
 Asp Gly Gly Gly Leu Leu Tyr Gly Leu Ala Ser Gly Val Ala Thr Gly
                 245                 250                 255

 ctc tgg act gtc ttc aca cta ggt ggt gtg ggc agc aaa gcg gct gcc      996
 Leu Trp Thr Val Phe Thr Leu Gly Gly Val Gly Ser Lys Ala Ala Ala
             260                 265                 270

 tct cca gag ctt tct tcc cct ctg gcc aac cag agt ctc ctg ctt ctg     1044
 Ser Pro Glu Leu Ser Ser Pro Leu Ala Asn Gln Ser Leu Leu Leu Leu
         275                 280                 285

 ctg gtg ttg gcc aat ctg aca gat gcc tca gat gcg cca aac ccc tac     1092
 Leu Val Leu Ala Asn Leu Thr Asp Ala Ser Asp Ala Pro Asn Pro Tyr
     290                 295                 300

 aga caa gcc att atg tcc ttc aag aac aca caa gat agc agt cct ttc     1140
 Arg Gln Ala Ile Met Ser Phe Lys Asn Thr Gln Asp Ser Ser Pro Phe
 305                 310                 315                 320

 ccc tca tca att cca cat gcc ttc cag atc aac ttt aat agt ttg tac     1188
 Pro Ser Ser Ile Pro His Ala Phe Gln Ile Asn Phe Asn Ser Leu Tyr
                 325                 330                 335

 aca gct ctt tgt gaa cag cag aca tct gat caa gca act ctc ctc ttg     1236
 Thr Ala Leu Cys Glu Gln Gln Thr Ser Asp Gln Ala Thr Leu Leu Leu
             340                 345                 350

 tat acc ttg ctc cat caa aat agt aat att aga aca tac atg ttg gct     1284
 Tyr Thr Leu Leu His Gln Asn Ser Asn Ile Arg Thr Tyr Met Leu Ala
         355                 360                 365

 cgc aca gat atg gaa aat ctt gtt tta cca att ctt gag att ctg tat     1332
 Arg Thr Asp Met Glu Asn Leu Val Leu Pro Ile Leu Glu Ile Leu Tyr
     370                 375                 380

 cat gtt gaa gaa agg aat tca cac cat gtg tat atg gcc ctt ata ata     1380
 His Val Glu Glu Arg Asn Ser His His Val Tyr Met Ala Leu Ile Ile
 385                 390                 395                 400

 ttg ttg atc ctt acg gaa gat gat ggc ttc aac aga tcc att cat gaa     1428
 Leu Leu Ile Leu Thr Glu Asp Asp Gly Phe Asn Arg Ser Ile His Glu
                 405                 410                 415

 gtg ata cta aaa aat att act tgg tat tca gaa cga gtt tta act gaa     1476
 Val Ile Leu Lys Asn Ile Thr Trp Tyr Ser Glu Arg Val Leu Thr Glu
             420                 425                 430

 atc tcc ttg ggg agt ctc ctg atc ctg gtg gta ata aga acc att caa     1524
 Ile Ser Leu Gly Ser Leu Leu Ile Leu Val Val Ile Arg Thr Ile Gln
         435                 440                 445

 tac aac atg act agg aca cga gac aag tac ctt cac aca aat tgt ttg     1572
 Tyr Asn Met Thr Arg Thr Arg Asp Lys Tyr Leu His Thr Asn Cys Leu
     450                 455                 460

 gca gct tta gca aat atg tcg gca cag ttt cgt tct ctc cat cag tat     1620
 Ala Ala Leu Ala Asn Met Ser Ala Gln Phe Arg Ser Leu His Gln Tyr
 465                 470                 475                 480

 gct gcc cag agg atc atc agt tta ttt tct ttg ctg tct aaa aaa cac     1668
 Ala Ala Gln Arg Ile Ile Ser Leu Phe Ser Leu Leu Ser Lys Lys His
                 485                 490                 495

 aac aaa gtt ctg gaa caa gcc aca cag tcc ttg aga ggt tcg ctg agt     1716
 Asn Lys Val Leu Glu Gln Ala Thr Gln Ser Leu Arg Gly Ser Leu Ser
             500                 505                 510

 tct aat gat gtt cct cta cca gat tat gca caa gac cta aat gtc att     1764
 Ser Asn Asp Val Pro Leu Pro Asp Tyr Ala Gln Asp Leu Asn Val Ile
         515                 520                 525

 gaa gaa gtg att cga atg atg tta gag atc atc aac tcc tgc ctg aca     1812
 Glu Glu Val Ile Arg Met Met Leu Glu Ile Ile Asn Ser Cys Leu Thr
     530                 535                 540

 aat tcc ctt cac cac aac cca aac ttg gta tac gcc ctg ctt tac aaa     1860
 Asn Ser Leu His His Asn Pro Asn Leu Val Tyr Ala Leu Leu Tyr Lys
 545                 550                 555                 560

 cgc gat ctc ttt gaa caa ttt cga act cat cct tca ttt cag gat ata     1908
 Arg Asp Leu Phe Glu Gln Phe Arg Thr His Pro Ser Phe Gln Asp Ile
                 565                 570                 575

 atg caa aat att gat ctg gtg agt gta aat gaa gac att tat tat gat     1956
 Met Gln Asn Ile Asp Leu Val Ser Val Asn Glu Asp Ile Tyr Tyr Asp
             580                 585                 590

 tct ttt tta agt att aaa gca gag aat gtt taa taagcctt ggtaagaact     2007
 Ser Phe Leu Ser Ile Lys Ala Glu Asn Val 
         595                 600

 ataatagtaa gagtttcttc tttcaacatt aactgtattt gcagtctatt ttactataat   2067

 agttgtggta atctgtgtgt gtgttgtata tacacacaca tacatattta atacaattga   2127

 agtcatactt catacagttt tttattctga cttttttact ttacacttag accatgagca   2187

 tttttctgtg gtattatcaa ttctttgaaa gtctcacatt ttaatttcta tctagcccat   2247

 gtttgtgtcc taaaatatat ataactatta tcccattttt gctcatttat ttccagtatt   2307

 ttatatcaat tcataatgaa tgaaaagttt ataaataagt cttatctcaa attttaaaat   2367

 tatatttttg atatggtttt aaagctggaa ttttactagt ttttactgtc aaaagatatc   2427

 tttattttca agattcaaca caggttgcca aattgctttc cagaaaaact gtagaattta   2487

 tgcctgt                                                             2494




      <210> 212
      <211> 690
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (1)..(690)

      <400> 212
  atg gtg ccc aga gtc ccc ggc tct ggc tgg gcc cat aga ttt gct ctc      48
  Met Val Pro Arg Val Pro Gly Ser Gly Trp Ala His Arg Phe Ala Leu
    1               5                  10                  15

 tct ccc agg ctg gtt ggt gga ggc atc aga gct agc ttc cgc cgc agc       96
 Ser Pro Arg Leu Val Gly Gly Gly Ile Arg Ala Ser Phe Arg Arg Ser
              20                  25                  30

 ctg gca cct cag gtg ccg acc ttc tac ctg ccc tac ttc ctg gag gcc      144
 Leu Ala Pro Gln Val Pro Thr Phe Tyr Leu Pro Tyr Phe Leu Glu Ala
          35                  40                  45

 ggc ctg gag gcg gca gcc ttg gtc ttc ctg ctc ctg acg gca gat tgc      192
 Gly Leu Glu Ala Ala Ala Leu Val Phe Leu Leu Leu Thr Ala Asp Cys
      50                  55                  60

 tgt gga cgc cgc ccc gtg ctg ctg ctg ggc acc atg gtc aca ggc ctg      240
 Cys Gly Arg Arg Pro Val Leu Leu Leu Gly Thr Met Val Thr Gly Leu
  65                  70                  75                  80

 gca tcc ctg ctg ctc ctc gct ggg gcc cag tat ctg cca ggc tgg act      288
 Ala Ser Leu Leu Leu Leu Ala Gly Ala Gln Tyr Leu Pro Gly Trp Thr
                  85                  90                  95

 gtg ctg ttc ctc tct gtc ctg ggg ctc ctg gcc tcc cgg gct gtg tcc      336
 Val Leu Phe Leu Ser Val Leu Gly Leu Leu Ala Ser Arg Ala Val Ser
             100                 105                 110

 gca ctc agc agc ctc ttc gcg gcc gag gtc ttc ccc acg gtg atc agg      384
 Ala Leu Ser Ser Leu Phe Ala Ala Glu Val Phe Pro Thr Val Ile Arg
         115                 120                 125

 ggg gcc ggg ctg ggc ctg gtg ctg ggg gcc ggg ttc ctg ggc cag gca      432
 Gly Ala Gly Leu Gly Leu Val Leu Gly Ala Gly Phe Leu Gly Gln Ala
     130                 135                 140

 gcc ggc ccc ctg gac acc ctg cac ggc cgg cag ggc ttc ttc ctg caa      480
 Ala Gly Pro Leu Asp Thr Leu His Gly Arg Gln Gly Phe Phe Leu Gln
 145                 150                 155                 160

 caa gtc gtc ttc gcc tcc ctt gct gtc ctt gcc ctg ctg tgt gtc ctg      528
 Gln Val Val Phe Ala Ser Leu Ala Val Leu Ala Leu Leu Cys Val Leu
                 165                 170                 175

 ctg ctg cct gag agc cga agc cgg ggg ctg ccc cag tca ctg cag gac      576
 Leu Leu Pro Glu Ser Arg Ser Arg Gly Leu Pro Gln Ser Leu Gln Asp
             180                 185                 190

 gcc gac cgc ctg cgc cgc tcc cca ctc ctg cgg ggc cgc ccc cgc cag      624
 Ala Asp Arg Leu Arg Arg Ser Pro Leu Leu Arg Gly Arg Pro Arg Gln
         195                 200                 205

 gac cac ctg cct ctg ctg ccg ccc tcc aac tcc tac tgg gcc ggc cac      672
 Asp His Leu Pro Leu Leu Pro Pro Ser Asn Ser Tyr Trp Ala Gly His
     210                 215                 220

 acc ccc gag cag cac tag                                              690
 Thr Pro Glu Gln His 
 225





      <210> 213
      <211> 1497
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (1)..(1443)

      <400> 213
  atg aat aaa caa aga gga acc tac tca gaa gtg agt ctg gcc cag gac      48
  Met Asn Lys Gln Arg Gly Thr Tyr Ser Glu Val Ser Leu Ala Gln Asp
    1               5                  10                  15

 cca aag agg cag caa agg aaa ctt aag ggc aat aaa atc tcc att tca       96
 Pro Lys Arg Gln Gln Arg Lys Leu Lys Gly Asn Lys Ile Ser Ile Ser
              20                  25                  30

 gga acc aaa cag gaa ata ttc caa gta gaa tta aac ctt caa aat gct      144
 Gly Thr Lys Gln Glu Ile Phe Gln Val Glu Leu Asn Leu Gln Asn Ala
          35                  40                  45

 tct tcg gat cat caa ggg aat gac aag aca tat cac tgc aaa ggt tta      192
 Ser Ser Asp His Gln Gly Asn Asp Lys Thr Tyr His Cys Lys Gly Leu
      50                  55                  60

 ctg cca cct cca gag aag ctc act gct gag gtc cta gga atc att tgc      240
 Leu Pro Pro Pro Glu Lys Leu Thr Ala Glu Val Leu Gly Ile Ile Cys
  65                  70                  75                  80

 att gtc ctg atg gcc act gtg tta aaa aca ata gtt ctt att cct tgt      288
 Ile Val Leu Met Ala Thr Val Leu Lys Thr Ile Val Leu Ile Pro Cys
                  85                  90                  95

 att gga gta ctg gag cag aac aat ttt tcc ctg aat aga aga atg cag      336
 Ile Gly Val Leu Glu Gln Asn Asn Phe Ser Leu Asn Arg Arg Met Gln
             100                 105                 110

 aaa gag atg agt gaa ttt cat aat tat aac ttg gat ctg aag aag agt      384
 Lys Glu Met Ser Glu Phe His Asn Tyr Asn Leu Asp Leu Lys Lys Ser
         115                 120                 125

 gat ttt tca aca cga tgg caa aag caa aga tgt cca gta gtc aaa agc      432
 Asp Phe Ser Thr Arg Trp Gln Lys Gln Arg Cys Pro Val Val Lys Ser
     130                 135                 140

 aaa tgt aga gaa aat gca tct cca ttt ttt ttc tgc tgc ttc atc gct      480
 Lys Cys Arg Glu Asn Ala Ser Pro Phe Phe Phe Cys Cys Phe Ile Ala
 145                 150                 155                 160

 gta gcc atg gga atc cgt ttc att att atg gta gca ata tgg agt gct      528
 Val Ala Met Gly Ile Arg Phe Ile Ile Met Val Ala Ile Trp Ser Ala
                 165                 170                 175

 gta ttc cta aac tca tta ttc aac caa gaa gtt caa att ccc ttg acc      576
 Val Phe Leu Asn Ser Leu Phe Asn Gln Glu Val Gln Ile Pro Leu Thr
             180                 185                 190

 gaa agt tac tgt ggc cca tgt cct aaa aac tgg ata tgt tac aaa aat      624
 Glu Ser Tyr Cys Gly Pro Cys Pro Lys Asn Trp Ile Cys Tyr Lys Asn
         195                 200                 205

 aac tgc tac caa ttt ttt gat gag agt aaa aac tgg tat gag agc cag      672
 Asn Cys Tyr Gln Phe Phe Asp Glu Ser Lys Asn Trp Tyr Glu Ser Gln
     210                 215                 220

 gct tct tgt atg tct caa aat gcc agc ctt ctg aaa gta tac agc aaa      720
 Ala Ser Cys Met Ser Gln Asn Ala Ser Leu Leu Lys Val Tyr Ser Lys
 225                 230                 235                 240

 gag gac cag gtc cag cag acc cgg tcc tat tac agg agt ttc gga cac      768
 Glu Asp Gln Val Gln Gln Thr Arg Ser Tyr Tyr Arg Ser Phe Gly His
                 245                 250                 255

 tgc tta gcc agg aag gtg tct tcc cct gtc aca gcc tgc tac agc tgc      816
 Cys Leu Ala Arg Lys Val Ser Ser Pro Val Thr Ala Cys Tyr Ser Cys
             260                 265                 270

 aaa gct cgt cct atc agc tgt atg caa tgt cct agg tct gat ttc ccc      864
 Lys Ala Arg Pro Ile Ser Cys Met Gln Cys Pro Arg Ser Asp Phe Pro
         275                 280                 285

 cca cac tcg cct cag agc aca cag ccc gtg cta agg gat ctg tgc ctc      912
 Pro His Ser Pro Gln Ser Thr Gln Pro Val Leu Arg Asp Leu Cys Leu
     290                 295                 300

 ccc acg tca ctc cct gca ttg gcc tct ccc gag acc atc gct ttc aca      960
 Pro Thr Ser Leu Pro Ala Leu Ala Ser Pro Glu Thr Ile Ala Phe Thr
 305                 310                 315                 320

 cac ttt cac aca cct tcc ttg ccc cag gat tcc tca ttg gac gaa atg     1008
 His Phe His Thr Pro Ser Leu Pro Gln Asp Ser Ser Leu Asp Glu Met
                 325                 330                 335

 agc ctc tct cat gtc ccg gat cca gtg aac cac ttt cac ttt gtt agt     1056
 Ser Leu Ser His Val Pro Asp Pro Val Asn His Phe His Phe Val Ser
             340                 345                 350

 ggg gac ata agc ttc atc caa att ggc agg cca ctc ctg ctg ccc cca     1104
 Gly Asp Ile Ser Phe Ile Gln Ile Gly Arg Pro Leu Leu Leu Pro Pro
         355                 360                 365

 gcc act ctg ggt tgg att agt ggt cag tcc ctg gga ggt gat caa gct     1152
 Ala Thr Leu Gly Trp Ile Ser Gly Gln Ser Leu Gly Gly Asp Gln Ala
     370                 375                 380

 ccc ctt tgt ccc tat ggg acg ggc ttt cct gcc ttg ggc cta tac tcc     1200
 Pro Leu Cys Pro Tyr Gly Thr Gly Phe Pro Ala Leu Gly Leu Tyr Ser
 385                 390                 395                 400

 tta cca cag ttc ctg aag tgc tgg tat cgt cct gca gcc cca tcc tcg     1248
 Leu Pro Gln Phe Leu Lys Cys Trp Tyr Arg Pro Ala Ala Pro Ser Ser
                 405                 410                 415

 gtt cca ttg cgc tgc cag gca ggg tgc tgg gac gtg ggg aga gct ggt     1296
 Val Pro Leu Arg Cys Gln Ala Gly Cys Trp Asp Val Gly Arg Ala Gly
             420                 425                 430

 cta tat atc cgg gtg aag ctc agc tgt ggc aca cct tgg atg ccg ggt     1344
 Leu Tyr Ile Arg Val Lys Leu Ser Cys Gly Thr Pro Trp Met Pro Gly
         435                 440                 445

 ctc tcc tgg ccc cgg gga cct agt atc gca ggc aaa ggg gac agt aaa     1392
 Leu Ser Trp Pro Arg Gly Pro Ser Ile Ala Gly Lys Gly Asp Ser Lys
     450                 455                 460

 tct gtc atc tcc aat cct gat gag ccc cca gaa atg tat cgg gat ata     1440
 Ser Val Ile Ser Asn Pro Asp Glu Pro Pro Glu Met Tyr Arg Asp Ile
 465                 470                 475                 480

 taa ggaa tcagagagac caagggattg aggaggatat ttattattta ggtgcactgg     1497
 






      <210> 214
      <211> 1396
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (1)..(1329)

      <400> 214
  atg cag aca gac cca cga gta ggc ttt tgc aga gtc cag gat gaa agc      48
  Met Gln Thr Asp Pro Arg Val Gly Phe Cys Arg Val Gln Asp Glu Ser
    1               5                  10                  15

 aaa tct cct agg ttg gca ttc gag gcc cat cac aag cgg ctc tca caa       96
 Lys Ser Pro Arg Leu Ala Phe Glu Ala His His Lys Arg Leu Ser Gln
              20                  25                  30

 ccc cct gcc aat gat gga cac tta atc cag aca gcc agg agt gga tat      144
 Pro Pro Ala Asn Asp Gly His Leu Ile Gln Thr Ala Arg Ser Gly Tyr
          35                  40                  45

 aca gat tca gga tac aga atc aga gat ttg gac gaa gat ttt ggc act      192
 Thr Asp Ser Gly Tyr Arg Ile Arg Asp Leu Asp Glu Asp Phe Gly Thr
      50                  55                  60

 gcc act ctt ggc tgg gca gga cag gaa gta cag aca gag aac gtg aca      240
 Ala Thr Leu Gly Trp Ala Gly Gln Glu Val Gln Thr Glu Asn Val Thr
  65                  70                  75                  80

 gtg gct gag ggt ggg gtg gct gag atc acc tgc cgt ctg cac cag tat      288
 Val Ala Glu Gly Gly Val Ala Glu Ile Thr Cys Arg Leu His Gln Tyr
                  85                  90                  95

 gat ggg tcc ata gtt gtc atc cag aac cca gcc cgg cag acc ctc ttc      336
 Asp Gly Ser Ile Val Val Ile Gln Asn Pro Ala Arg Gln Thr Leu Phe
             100                 105                 110

 ttc aat ggc acc cgt gcc ttg aag gat gag cgt ttc cag ctt gag gag      384
 Phe Asn Gly Thr Arg Ala Leu Lys Asp Glu Arg Phe Gln Leu Glu Glu
         115                 120                 125

 ttc tcc cca cgc cgg gtg cgg atc cgg ctc tca gat gcc cgc ctg gag      432
 Phe Ser Pro Arg Arg Val Arg Ile Arg Leu Ser Asp Ala Arg Leu Glu
     130                 135                 140

 gac gag ggg ggc tat ttc tgc cag ctc tac aca gaa gac acc cac cac      480
 Asp Glu Gly Gly Tyr Phe Cys Gln Leu Tyr Thr Glu Asp Thr His His
 145                 150                 155                 160

 cag att gcc acg ctc acg gta cta gtg gcc cca gag aat cct gtg gtg      528
 Gln Ile Ala Thr Leu Thr Val Leu Val Ala Pro Glu Asn Pro Val Val
                 165                 170                 175

 gag gtc cgg gag cag gcg gta gag ggc ggc gag gtg gag ctc agc tgc      576
 Glu Val Arg Glu Gln Ala Val Glu Gly Gly Glu Val Glu Leu Ser Cys
             180                 185                 190

 ctc gtt ccg cgg tcc cgt ccg gct gcc acc ctg cgc tgg tac cgg gac      624
 Leu Val Pro Arg Ser Arg Pro Ala Ala Thr Leu Arg Trp Tyr Arg Asp
         195                 200                 205

 cgc aag gag ctg aaa gtg tct gac cgg ggt gtg gca gga gtg agc agc      672
 Arg Lys Glu Leu Lys Val Ser Asp Arg Gly Val Ala Gly Val Ser Ser
     210                 215                 220

 agc cag gaa aat ggc aag gtc tgg agc gtg gca agc aca gta cgg ttt      720
 Ser Gln Glu Asn Gly Lys Val Trp Ser Val Ala Ser Thr Val Arg Phe
 225                 230                 235                 240

 cgt gtg gac cgt aag gac gac ggt ggt atc atc atc tgt gag gcg cag      768
 Arg Val Asp Arg Lys Asp Asp Gly Gly Ile Ile Ile Cys Glu Ala Gln
                 245                 250                 255

 aac cag gcg ctg ccc tcc gga cac agc aag cag acg cag tac gtg ctg      816
 Asn Gln Ala Leu Pro Ser Gly His Ser Lys Gln Thr Gln Tyr Val Leu
             260                 265                 270

 gat gtg cag tac tcc ccc acg gcc cgg att cat gcc tcc caa gct gtg      864
 Asp Val Gln Tyr Ser Pro Thr Ala Arg Ile His Ala Ser Gln Ala Val
         275                 280                 285

 gtg agg gag gga gac acg ctg gtg ttg acg tgt gct gtc acg ggg aac      912
 Val Arg Glu Gly Asp Thr Leu Val Leu Thr Cys Ala Val Thr Gly Asn
     290                 295                 300

 ccc agg cca aac cag atc cgc tgg aac cgc ggg aat gag tct ttg ccg      960
 Pro Arg Pro Asn Gln Ile Arg Trp Asn Arg Gly Asn Glu Ser Leu Pro
 305                 310                 315                 320

 gag agg gcg gag gcc gtg gga gag acg ctc acg ctg ccg ggt ctg gta     1008
 Glu Arg Ala Glu Ala Val Gly Glu Thr Leu Thr Leu Pro Gly Leu Val
                 325                 330                 335

 tcc gcg gat aac ggc acc tac act tgc gag gcg tcc aat aag cac ggc     1056
 Ser Ala Asp Asn Gly Thr Tyr Thr Cys Glu Ala Ser Asn Lys His Gly
             340                 345                 350

 cat gcg agg gcg ctc tac gta ctt gtg gtc tac gac cct ggt gcg gtg     1104
 His Ala Arg Ala Leu Tyr Val Leu Val Val Tyr Asp Pro Gly Ala Val
         355                 360                 365

 gta gag gct cag acg tcg gtt ccc tat gcc att gtg ggc ggt atc ctg     1152
 Val Glu Ala Gln Thr Ser Val Pro Tyr Ala Ile Val Gly Gly Ile Leu
     370                 375                 380

 gcg ctg ctg gtg ttt ctg atc ata tgt gtg cta gtg ggc atg gtc tgg     1200
 Ala Leu Leu Val Phe Leu Ile Ile Cys Val Leu Val Gly Met Val Trp
 385                 390                 395                 400

 tgc tcg gta cgg cag aag ggt tcc tat ctg acc cac gaa gcc agt ggc     1248
 Cys Ser Val Arg Gln Lys Gly Ser Tyr Leu Thr His Glu Ala Ser Gly
                 405                 410                 415

 ttg gat gaa cag gga gaa gta aga gaa gcc ttc ctc aat ggc agc gac     1296
 Leu Asp Glu Gln Gly Glu Val Arg Glu Ala Phe Leu Asn Gly Ser Asp
             420                 425                 430

 gga cac aag agg aaa gag gaa ttc ttc atc tga ccctatcc ccaccccagg     1347
 Gly His Lys Arg Lys Glu Glu Phe Phe Ile 
         435                 440

 cctaggcctg ggcctgggct ggggtccccc ccactgccag ctgcaagcc               1396




      <210> 215
      <211> 6586
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (115)..(5070)

      <220>
      <221> misc_feature
      <222> (1)...(6586)
      <223> n = a,t,c or g

      <400> 215
 cgccgttgtg tttcatttat tcttcgaact actataggtg gtcttcttgg agaaaaggct     60

 cagcttgctg ctgtaaagga tatttgccag gccatctgga agctaaagaa agtt  atg     117
                                                              Met
                                                                1

 gat gcc gta atg agt gat ggt aat ttg gaa acc cgg ctt ggt tcc aca      165
 Asp Ala Val Met Ser Asp Gly Asn Leu Glu Thr Arg Leu Gly Ser Thr
               5                  10                  15

 gat gta gcc gct agc caa cat atg ctg gtt tgt gct tta caa gaa ctt      213
 Asp Val Ala Ala Ser Gln His Met Leu Val Cys Ala Leu Gln Glu Leu
          20                  25                  30

 gga aat ctc ata cac aat ctt ggc acc aca gcg gca cct ttg cta cag      261
 Gly Asn Leu Ile His Asn Leu Gly Thr Thr Ala Ala Pro Leu Leu Gln
      35                  40                  45

 gat tca agt aca ggt ctc ctt gac agt atc ttg tca gtt att ctt cat      309
 Asp Ser Ser Thr Gly Leu Leu Asp Ser Ile Leu Ser Val Ile Leu His
  50                  55                  60                  65

 cct agc att tct gtt cga cta gca gca gct tgg tgt tta cac tgc att      357
 Pro Ser Ile Ser Val Arg Leu Ala Ala Ala Trp Cys Leu His Cys Ile
                  70                  75                  80

 gcc gtg gca tta ccc tcc tac cta aca cca ctc ttg gat cgt tgc ctt      405
 Ala Val Ala Leu Pro Ser Tyr Leu Thr Pro Leu Leu Asp Arg Cys Leu
              85                  90                  95

 gaa cgg ctt act gga cat aag tct tca cct gaa gca gtg act ggc ttc      453
 Glu Arg Leu Thr Gly His Lys Ser Ser Pro Glu Ala Val Thr Gly Phe
         100                 105                 110

 agt ttt gct gta gca gct ttg ttg gga gca gta aaa cat tgt cct tta      501
 Ser Phe Ala Val Ala Ala Leu Leu Gly Ala Val Lys His Cys Pro Leu
     115                 120                 125

 gga att cct cat gga aaa ggc aag att att atg aca tta gca gag gat      549
 Gly Ile Pro His Gly Lys Gly Lys Ile Ile Met Thr Leu Ala Glu Asp
 130                 135                 140                 145

 ttg ctg tgt tct gct gct caa aac agt cgc ctt tca gct cag cgc aca      597
 Leu Leu Cys Ser Ala Ala Gln Asn Ser Arg Leu Ser Ala Gln Arg Thr
                 150                 155                 160

 caa gct gga tgg ttg ctg att tct gct ctg atg aca tta ggt cct gca      645
 Gln Ala Gly Trp Leu Leu Ile Ser Ala Leu Met Thr Leu Gly Pro Ala
             165                 170                 175

 gtt gtt agc cat cac ctt gct cga gtt ctg ctg ttg tgg aag tgt gtc      693
 Val Val Ser His His Leu Ala Arg Val Leu Leu Leu Trp Lys Cys Val
         180                 185                 190

 ttt cca gca tct cct aaa gat cta gaa aca gaa aag agc cga gga gat      741
 Phe Pro Ala Ser Pro Lys Asp Leu Glu Thr Glu Lys Ser Arg Gly Asp
     195                 200                 205

 tcg ttt aca tgg cag gtg acc ctg gaa gga cga gct ggt gca ctg tgt      789
 Ser Phe Thr Trp Gln Val Thr Leu Glu Gly Arg Ala Gly Ala Leu Cys
 210                 215                 220                 225

 gct atc aag agc ttt gtt tcc cac tgt ggt gat ctt ctt act gag gaa      837
 Ala Ile Lys Ser Phe Val Ser His Cys Gly Asp Leu Leu Thr Glu Glu
                 230                 235                 240

 gta act cag cgt ctt ctt cca cca ctt cct tgt gct gtg gat ttg cta      885
 Val Thr Gln Arg Leu Leu Pro Pro Leu Pro Cys Ala Val Asp Leu Leu
             245                 250                 255

 act cag ctt tct tca ata cta aaa atg tat gga agt cct ttg aaa aca      933
 Thr Gln Leu Ser Ser Ile Leu Lys Met Tyr Gly Ser Pro Leu Lys Thr
         260                 265                 270

 ccg tca gtg gtt tat aga caa aga ctt tat gaa ctg ttg att tta tta      981
 Pro Ser Val Val Tyr Arg Gln Arg Leu Tyr Glu Leu Leu Ile Leu Leu
     275                 280                 285

 cct cct gag acc tat gaa gga aac ctc tgt gct atc ctc aga gag ctg     1029
 Pro Pro Glu Thr Tyr Glu Gly Asn Leu Cys Ala Ile Leu Arg Glu Leu
 290                 295                 300                 305

 gct gct gac ttg act gcc cct gat att cag gtg gca gca tct aca ttt     1077
 Ala Ala Asp Leu Thr Ala Pro Asp Ile Gln Val Ala Ala Ser Thr Phe
                 310                 315                 320

 tta ctt cca ccc ctc tgt cat cag gat gat ctt ttg ata cta agt cct     1125
 Leu Leu Pro Pro Leu Cys His Gln Asp Asp Leu Leu Ile Leu Ser Pro
             325                 330                 335

 ttc cta caa gag act gac cat aga ttt att gaa gaa cag ctc ctg ctt     1173
 Phe Leu Gln Glu Thr Asp His Arg Phe Ile Glu Glu Gln Leu Leu Leu
         340                 345                 350

 ggt aat ggt gtt gct tgc gga agt ctt gaa tat gac cct tat tcg att     1221
 Gly Asn Gly Val Ala Cys Gly Ser Leu Glu Tyr Asp Pro Tyr Ser Ile
     355                 360                 365

 tat gag aaa gat gta gag gga gat tca gtg cct aag ccc tta cct cca     1269
 Tyr Glu Lys Asp Val Glu Gly Asp Ser Val Pro Lys Pro Leu Pro Pro
 370                 375                 380                 385

 gca cta tca gtt att agt tct gca tcc aag ctc ttt ggg gtt gta tgc     1317
 Ala Leu Ser Val Ile Ser Ser Ala Ser Lys Leu Phe Gly Val Val Cys
                 390                 395                 400

 gct cat gtg gga gaa act caa agg ctt ctt ata ctg gaa cag ctt ttg     1365
 Ala His Val Gly Glu Thr Gln Arg Leu Leu Ile Leu Glu Gln Leu Leu
             405                 410                 415

 gac agt ata aag cac aca aaa gga gct cgt cag caa gtg gtt cag tta     1413
 Asp Ser Ile Lys His Thr Lys Gly Ala Arg Gln Gln Val Val Gln Leu
         420                 425                 430

 cat gtt gtt tct tca gtt tct agt ttc ttg aag tac gtg gct ggc tcc     1461
 His Val Val Ser Ser Val Ser Ser Phe Leu Lys Tyr Val Ala Gly Ser
     435                 440                 445

 aag gga tgt tta ggt cca gaa gaa atg aaa aga ttt gcc tta aca tta     1509
 Lys Gly Cys Leu Gly Pro Glu Glu Met Lys Arg Phe Ala Leu Thr Leu
 450                 455                 460                 465

 gtt atg gga gcc cta gaa agc ccc aac ccc ttg ctg aga tgt gca gct     1557
 Val Met Gly Ala Leu Glu Ser Pro Asn Pro Leu Leu Arg Cys Ala Ala
                 470                 475                 480

 gca gag tca tgg gct aga tta gcc caa atg gta gat gat gga gct ttt     1605
 Ala Glu Ser Trp Ala Arg Leu Ala Gln Met Val Asp Asp Gly Ala Phe
             485                 490                 495

 act gct gga tta gct caa gtt agc ttt gac aaa ttg aaa tca gca agg     1653
 Thr Ala Gly Leu Ala Gln Val Ser Phe Asp Lys Leu Lys Ser Ala Arg
         500                 505                 510

 gat gtg gtt acc aga aca gga cac tca ttg gcc ttg ggg tcc cta cat     1701
 Asp Val Val Thr Arg Thr Gly His Ser Leu Ala Leu Gly Ser Leu His
     515                 520                 525

 agg tat tta gga gga ata agt tct tct caa cac cta aat tct tgt att     1749
 Arg Tyr Leu Gly Gly Ile Ser Ser Ser Gln His Leu Asn Ser Cys Ile
 530                 535                 540                 545

 gga atc ctt tat act ttg gcg cag gac agc act tct cct gat gtg cag     1797
 Gly Ile Leu Tyr Thr Leu Ala Gln Asp Ser Thr Ser Pro Asp Val Gln
                 550                 555                 560

 acc tgg gca tta cat tct cta tca ttg atc att gat tct gct ggc cca     1845
 Thr Trp Ala Leu His Ser Leu Ser Leu Ile Ile Asp Ser Ala Gly Pro
             565                 570                 575

 ctc tat tat gtg cat gtg gaa cct acc ctt tct ctt att ata atg ttg     1893
 Leu Tyr Tyr Val His Val Glu Pro Thr Leu Ser Leu Ile Ile Met Leu
         580                 585                 590

 ttg tta aat gtg cct cct act cat gct gaa gtt cac caa agc ctt ggt     1941
 Leu Leu Asn Val Pro Pro Thr His Ala Glu Val His Gln Ser Leu Gly
     595                 600                 605

 cgc tgt ttg aat gcc ctt att acc acg tta ggt cca gag cta caa ggt     1989
 Arg Cys Leu Asn Ala Leu Ile Thr Thr Leu Gly Pro Glu Leu Gln Gly
 610                 615                 620                 625

 aac agt act tca att tct acc tta agg act tcc tgt cta ctg ggt tgt     2037
 Asn Ser Thr Ser Ile Ser Thr Leu Arg Thr Ser Cys Leu Leu Gly Cys
                 630                 635                 640

 gca gta atg caa gat aac cca gac tgc ctt gtt caa gct cag gcc atc     2085
 Ala Val Met Gln Asp Asn Pro Asp Cys Leu Val Gln Ala Gln Ala Ile
             645                 650                 655

 tct tgc ctt cag cag ctt cat atg ttt gct cca cga cat gtc aac ttg     2133
 Ser Cys Leu Gln Gln Leu His Met Phe Ala Pro Arg His Val Asn Leu
         660                 665                 670

 tct agc ctg gtt agc tgc ctc tgt gtg aat ctt tgt agc ccc tac ttg     2181
 Ser Ser Leu Val Ser Cys Leu Cys Val Asn Leu Cys Ser Pro Tyr Leu
     675                 680                 685

 tta ctg aga aga gca gta ctg gct tgc tta cgt cag ctt gta caa aga     2229
 Leu Leu Arg Arg Ala Val Leu Ala Cys Leu Arg Gln Leu Val Gln Arg
 690                 695                 700                 705

 gaa gca gct gaa gtt tca gaa cat gct gtt atg ctt gct aag gat agc     2277
 Glu Ala Ala Glu Val Ser Glu His Ala Val Met Leu Ala Lys Asp Ser
                 710                 715                 720

 aga gaa gag ttg act cca gat gct aac atc aga gaa gtt ggc ctt gag     2325
 Arg Glu Glu Leu Thr Pro Asp Ala Asn Ile Arg Glu Val Gly Leu Glu
             725                 730                 735

 ggg gca ttg ttg atc tta cta gac aag gag aca gat gag aga tta tgc     2373
 Gly Ala Leu Leu Ile Leu Leu Asp Lys Glu Thr Asp Glu Arg Leu Cys
         740                 745                 750

 cat gat atc aaa gag act tta aat tat atg ctt aca tct atg gca gtg     2421
 His Asp Ile Lys Glu Thr Leu Asn Tyr Met Leu Thr Ser Met Ala Val
     755                 760                 765

 gaa aaa ctc tcc ctg tgg tta aag ctt tgt aaa gat gta ctt gct gca     2469
 Glu Lys Leu Ser Leu Trp Leu Lys Leu Cys Lys Asp Val Leu Ala Ala
 770                 775                 780                 785

 tca gct gat ttt aca gct gta act tgt gtg gat aca atg caa gaa gaa     2517
 Ser Ala Asp Phe Thr Ala Val Thr Cys Val Asp Thr Met Gln Glu Glu
                 790                 795                 800

 gaa gga gat aaa ggg gat gat gcc tca gtc ctg acc acc aga cgt gat     2565
 Glu Gly Asp Lys Gly Asp Asp Ala Ser Val Leu Thr Thr Arg Arg Asp
             805                 810                 815

 gaa aaa tcc cat cct ttt acc aat ccc cga tgg gct act aga gtc ttt     2613
 Glu Lys Ser His Pro Phe Thr Asn Pro Arg Trp Ala Thr Arg Val Phe
         820                 825                 830

 gct gct gaa tgt gtc tgt agg ata att aac caa tgt gag aat gct aac     2661
 Ala Ala Glu Cys Val Cys Arg Ile Ile Asn Gln Cys Glu Asn Ala Asn
     835                 840                 845

 agt gca cat ttt gac att gct tta gca caa gaa atg aaa aaa aga gat     2709
 Ser Ala His Phe Asp Ile Ala Leu Ala Gln Glu Met Lys Lys Arg Asp
 850                 855                 860                 865

 tca aga aat gac ttt ttg gta ctg cat ctt gct gac tta att cgc atg     2757
 Ser Arg Asn Asp Phe Leu Val Leu His Leu Ala Asp Leu Ile Arg Met
                 870                 875                 880

 gct ttt atg gct gcc aca gat cac agt gac cag ctc cgt ctt tct ggc     2805
 Ala Phe Met Ala Ala Thr Asp His Ser Asp Gln Leu Arg Leu Ser Gly
             885                 890                 895

 ctt gaa atg ctg tta gtt gtt att cgg cga ttt gca act gtt cca gaa     2853
 Leu Glu Met Leu Leu Val Val Ile Arg Arg Phe Ala Thr Val Pro Glu
         900                 905                 910

 cca gag ttt cca ggt cat gtg att ctg gaa cag tat caa gcc aat gta     2901
 Pro Glu Phe Pro Gly His Val Ile Leu Glu Gln Tyr Gln Ala Asn Val
     915                 920                 925

 gga gca gcg ctt aga cca gcc ttc act tca gag aca cca cct gat gtc     2949
 Gly Ala Ala Leu Arg Pro Ala Phe Thr Ser Glu Thr Pro Pro Asp Val
 930                 935                 940                 945

 act gcc aaa gca tgt cag gtt tgc agt gcc tgg ata gca agt gga gtt     2997
 Thr Ala Lys Ala Cys Gln Val Cys Ser Ala Trp Ile Ala Ser Gly Val
                 950                 955                 960

 gta agt gac ctt aat gat ctc cga aga gtt cat cag ttg ctt gtt tca     3045
 Val Ser Asp Leu Asn Asp Leu Arg Arg Val His Gln Leu Leu Val Ser
             965                 970                 975

 tcg tta act aaa ata cag gct gga aaa gaa gct cta agt cac tta tat     3093
 Ser Leu Thr Lys Ile Gln Ala Gly Lys Glu Ala Leu Ser His Leu Tyr
         980                 985                 990

 aat gaa agt gct tct acc atg gag atc tta gct gtg ctt aaa gcc tgg     3141
 Asn Glu Ser Ala Ser Thr Met Glu Ile Leu Ala Val Leu Lys Ala Trp
     995                1000                1005

 gca gag gtc tac ata att gct gtg caa aga cat aaa aac cac aga caa     3189
 Ala Glu Val Tyr Ile Ile Ala Val Gln Arg His Lys Asn His Arg Gln
1010                1015                1020                1025

 cct ttg aag act acc acc tgt tta gaa gac ggt atc aga aat gga tca     3237
 Pro Leu Lys Thr Thr Thr Cys Leu Glu Asp Gly Ile Arg Asn Gly Ser
                1030                1035                1040

 tgt tca tca gat gga ctg ctt gac tta gtc tat gca gat ctt ggc aca     3285
 Cys Ser Ser Asp Gly Leu Leu Asp Leu Val Tyr Ala Asp Leu Gly Thr
            1045                1050                1055

 cta agc aga ctc tgg ctt gct gca ctt cag gat ttt gct ctt tta act     3333
 Leu Ser Arg Leu Trp Leu Ala Ala Leu Gln Asp Phe Ala Leu Leu Thr
        1060                1065                1070

 ttg cct tca gaa ttt gcc tcc caa ctt cct gct gaa ggt ggt gct ttc     3381
 Leu Pro Ser Glu Phe Ala Ser Gln Leu Pro Ala Glu Gly Gly Ala Phe
    1075                1080                1085

 tac aca gca gag act agt gaa aat gca aaa ttg cat tat tac aac tcc     3429
 Tyr Thr Ala Glu Thr Ser Glu Asn Ala Lys Leu His Tyr Tyr Asn Ser
1090                1095                1100                1105

 tgg gca ctt atc ctc cat gct aca gca ttg tgg ctt aca agc acg ggt     3477
 Trp Ala Leu Ile Leu His Ala Thr Ala Leu Trp Leu Thr Ser Thr Gly
                1110                1115                1120

 ttt gtt gtt gct gac cca gat gaa gga gca tct aat ctc tcc agg cct     3525
 Phe Val Val Ala Asp Pro Asp Glu Gly Ala Ser Asn Leu Ser Arg Pro
            1125                1130                1135

 gta aca cca act tcc atg tgt cag ggt tca tca tct ggg gct acc ata     3573
 Val Thr Pro Thr Ser Met Cys Gln Gly Ser Ser Ser Gly Ala Thr Ile
        1140                1145                1150

 aag tcc cct gag gat gtc tac act gat aga ttc cat ctt att tta gga     3621
 Lys Ser Pro Glu Asp Val Tyr Thr Asp Arg Phe His Leu Ile Leu Gly
    1155                1160                1165

 atc agc gtg gaa ttt cta tgt tcc tta cgt tca gat gca acc atg gaa     3669
 Ile Ser Val Glu Phe Leu Cys Ser Leu Arg Ser Asp Ala Thr Met Glu
1170                1175                1180                1185

 agc ata act gct tgt tta cat gca ttg caa gca ctt cta gat gta cct     3717
 Ser Ile Thr Ala Cys Leu His Ala Leu Gln Ala Leu Leu Asp Val Pro
                1190                1195                1200

 tgg ccc aga tca aaa att ggc agt gat cag gac ttg ggt ata gaa ttg     3765
 Trp Pro Arg Ser Lys Ile Gly Ser Asp Gln Asp Leu Gly Ile Glu Leu
            1205                1210                1215

 ctg aat gtt cta cat cga gta att tta acc aga gaa tca cct tcc att     3813
 Leu Asn Val Leu His Arg Val Ile Leu Thr Arg Glu Ser Pro Ser Ile
        1220                1225                1230

 cag ttg gct tca ctt gaa gtg gta agg cag att atc tgt gct gct caa     3861
 Gln Leu Ala Ser Leu Glu Val Val Arg Gln Ile Ile Cys Ala Ala Gln
    1235                1240                1245

 gaa cat gtg aag gaa aaa aga cga agt gca gaa gtt gat gat ggg gct     3909
 Glu His Val Lys Glu Lys Arg Arg Ser Ala Glu Val Asp Asp Gly Ala
1250                1255                1260                1265

 gct gaa aag gaa act ctg cca gag ttt gga gag gga aag gac acc gga     3957
 Ala Glu Lys Glu Thr Leu Pro Glu Phe Gly Glu Gly Lys Asp Thr Gly
                1270                1275                1280

 gga ctt gtg cct gga aag tct ttg gtc ttt gca aca ctg gaa ttg tgt     4005
 Gly Leu Val Pro Gly Lys Ser Leu Val Phe Ala Thr Leu Glu Leu Cys
            1285                1290                1295

 gta tgc att cta gtt aga cag ctc cca gaa tta aac cct aaa ttg aca     4053
 Val Cys Ile Leu Val Arg Gln Leu Pro Glu Leu Asn Pro Lys Leu Thr
        1300                1305                1310

 ggt agc cca gga gta aaa gct acg aag cca cag ata cta tta gaa gat     4101
 Gly Ser Pro Gly Val Lys Ala Thr Lys Pro Gln Ile Leu Leu Glu Asp
    1315                1320                1325

 gga agt aga ttg gtt tca gct gca ttg gtt atc ctt tcc gaa ctt cct     4149
 Gly Ser Arg Leu Val Ser Ala Ala Leu Val Ile Leu Ser Glu Leu Pro
1330                1335                1340                1345

 gca gtg tgc tct cct gaa gga agc atc tca att ctc cct act ata ttg     4197
 Ala Val Cys Ser Pro Glu Gly Ser Ile Ser Ile Leu Pro Thr Ile Leu
                1350                1355                1360

 tac ctc aca atc ggg gtc ctc aga gag act gct gtg aag tta cct ggg     4245
 Tyr Leu Thr Ile Gly Val Leu Arg Glu Thr Ala Val Lys Leu Pro Gly
            1365                1370                1375

 ggc cag tta tct tcg aca gtt gca gct tcc cta cag gct cta aaa gga     4293
 Gly Gln Leu Ser Ser Thr Val Ala Ala Ser Leu Gln Ala Leu Lys Gly
        1380                1385                1390

 ata tta tct tct ccc atg gcc cgg gca gaa aag agc cgt act gct tgg     4341
 Ile Leu Ser Ser Pro Met Ala Arg Ala Glu Lys Ser Arg Thr Ala Trp
    1395                1400                1405

 act gac ctt ctc cga agt gcc tta aca aca att ctt gac tgt tgg gat     4389
 Thr Asp Leu Leu Arg Ser Ala Leu Thr Thr Ile Leu Asp Cys Trp Asp
1410                1415                1420                1425

 cca gtt gat gaa aca cac caa gaa ctt gat gaa gtc agt cta ctt act     4437
 Pro Val Asp Glu Thr His Gln Glu Leu Asp Glu Val Ser Leu Leu Thr
                1430                1435                1440

 gct atc aca gtg ttt att ttg tct acc agt cca gaa gta act acc atc     4485
 Ala Ile Thr Val Phe Ile Leu Ser Thr Ser Pro Glu Val Thr Thr Ile
            1445                1450                1455

 cca tgc ctt cag aag cgc tgt att gat aaa ttt aaa gct act ctt gag     4533
 Pro Cys Leu Gln Lys Arg Cys Ile Asp Lys Phe Lys Ala Thr Leu Glu
        1460                1465                1470

 ata aaa gat cct gtg gta caa atc aag acc tac cag ctc cta cat tcc     4581
 Ile Lys Asp Pro Val Val Gln Ile Lys Thr Tyr Gln Leu Leu His Ser
    1475                1480                1485

 atc ttt cag tat cca aat cca gct gtt tcc tac cca tac att tac tct     4629
 Ile Phe Gln Tyr Pro Asn Pro Ala Val Ser Tyr Pro Tyr Ile Tyr Ser
1490                1495                1500                1505

 tta gca tcc tgt atc atg gaa aaa ctg cag gaa ata gac aag aga aaa     4677
 Leu Ala Ser Cys Ile Met Glu Lys Leu Gln Glu Ile Asp Lys Arg Lys
                1510                1515                1520

 cct gaa aac act gct gag ctt gag atc ttc caa gaa ggc ata aag gtc     4725
 Pro Glu Asn Thr Ala Glu Leu Glu Ile Phe Gln Glu Gly Ile Lys Val
            1525                1530                1535

 tta gaa aca ctg gtt act gtt gct gaa gaa cac cat cgc gct cag ctg     4773
 Leu Glu Thr Leu Val Thr Val Ala Glu Glu His His Arg Ala Gln Leu
        1540                1545                1550

 gtg gcc tgt ctt ttg ccc atc ctc att tcc ttc ctt ttg gat gaa aat     4821
 Val Ala Cys Leu Leu Pro Ile Leu Ile Ser Phe Leu Leu Asp Glu Asn
    1555                1560                1565

 tct ctg gga tca gca act tcc ata atg aga aat tta cat gac ttt gct     4869
 Ser Leu Gly Ser Ala Thr Ser Ile Met Arg Asn Leu His Asp Phe Ala
1570                1575                1580                1585

 cta caa aat ctc atg caa att gga cct cag tat tca tct gtt ttt aaa     4917
 Leu Gln Asn Leu Met Gln Ile Gly Pro Gln Tyr Ser Ser Val Phe Lys
                1590                1595                1600

 agt tta gtg gct tct tct cca gcc cta aaa gcc cgc ctt gag gct gct     4965
 Ser Leu Val Ala Ser Ser Pro Ala Leu Lys Ala Arg Leu Glu Ala Ala
            1605                1610                1615

 ata aag ggc aat cag gaa agt gtc aaa gtc aag ata cca aca tct aaa     5013
 Ile Lys Gly Asn Gln Glu Ser Val Lys Val Lys Ile Pro Thr Ser Lys
        1620                1625                1630

 tat act aag agt cct gga aaa aac tca agc atc caa tta aag acc agt     5061
 Tyr Thr Lys Ser Pro Gly Lys Asn Ser Ser Ile Gln Leu Lys Thr Ser
    1635                1640                1645

 ttc ctc tga ttttttt tttggaatag taagcacctt aatataataa atacttgatc     5117
 Phe Leu 
1650

 attgcctttg gtgacaaaag ggacattgta gacacaagtg cccttagagg tctagttgat   5177

 tgttttacct taaatagctg tgactcttca aagtaacagc atacttaaca tttttgtgtg   5237

 tgtgcgtggg gtttgtgttt tgttttgttt tgtttttcta tttaaaaaga caatggagct   5297

 aacttgccag gaattttaag aaagtgctaa agaactaaac ttactaaaca atccactgct   5357

 ttaaaaatga aatgaatttc ttctaacagt ccatacatat gtggtatact taatactgtg   5417

 acagatataa atatgactct agtgtaaatt atctgcacta atattgtatc ccaattgctg   5477

 atttnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn   5537

 nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn   5597

 nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn   5657

 nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn   5717

 nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn   5777

 nnnnnnnnnn nnnnnnnctg ccttattcag taattgtatt aaactttctc tgatttctcc   5837

 aagaagataa aatgattgga gagctattta ggaaacctgg tctaggatta tccagtatac   5897

 aatagtacaa attacttaca gccttacagt gcaacataag atttggtgtc tatatcatgg   5957

 ttttccacca tcttttggtt tagtttatat tgggttcaga aattgagtct tactcatttt   6017

 aaatagaata agccatttcc actatttttc aaatggattt ttctgtttac ctctgttctt   6077

 accaattttg ttcattttca tttgtggcaa acatttgtat caatgagttt taacctaggt   6137

 tcatatctac attgtattta gatcaactat gggtttatat aaatgccaaa tttagtacaa   6197

 caaatttagg tcatcaggtg aatacaagta ttttttttaa caggaaacat tttattatag   6257

 aaaaaagatt aatgataaag tcatattggt tgaaaaatat tttttaactg tgttcatgat   6317

 tgttgattct ccttctactt cagtgttata ctgtgtgaat caagcactgt gtcaaaacag   6377

 agcatttccc tcttaaaaat tacaaaccga agtgatagaa gcatgtcaga attgagaaga   6437

 cattttgaag caagaacaat gtgatgtacc tattttatta tgtttgtata taaatactat   6497

 tgtaaattgt tcagagtgaa aacatttgac aaactctaac actacaatca ttttttctaa   6557

 attacataaa taaagctatt tttcattat                                     6586




      <210> 216
      <211> 1285
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (650)..(1285)

      <400> 216
 ggtaagagtg tggatgtacc ctattacaag cacagagtca aaacctgagg ctgatcatgt     60

 catctaccac actccccaag tactcaatca tggcatctgt aagtccacct atggtgacct    120

 gaatacccaa atcctgggcc tgtcattgaa tagtagttcc ttcttaagtc agttaccctg    180

 gctctacatg cctcaagtgc tttgcttgaa aaacaggcaa aacaatttgt acttcaaggg    240

 tcattcgggt gattaaatag aatggatgct tgtggaaaca ccccataaac tggtgacatg    300

 gagagtatct gtacgtggga gttcatttta acttgatgcc agattcagga aggcttcact    360

 ggcttcttcc gagctatgat ggtgcctcct ctgtagtcct gccatcttct gggtttccgc    420

 ctctgggcaa ttttttgacc atctccactg gaagacagag aatggcttca gggccgggca    480

 cttgtgtctt cctgagtttc atgttcccca atcctaccat tggtatgtag taggtactca    540

 gagctttttt actgaatgag tcaactggtg agtaataaag aaagcaggaa ggagtggctg    600

 agtgaagaaa tctggaaaga aggaagggag ggaaaacacc aggtaggaa    atg agt     655
                                                          Met Ser
                                                            1

 gaa cga tgg aag agg aga ggg aat tca aca agg acc tcc tct ttg gct      703
 Glu Arg Trp Lys Arg Arg Gly Asn Ser Thr Arg Thr Ser Ser Leu Ala
           5                  10                  15

 tca gga gct ggg gac cct gaa cca gac ctg tgg atc atc cag ccc cag      751
 Ser Gly Ala Gly Asp Pro Glu Pro Asp Leu Trp Ile Ile Gln Pro Gln
      20                  25                  30

 gaa ttg gtg ttg ggg acc act gga gac act gtc ttt ctg aac tgc aca      799
 Glu Leu Val Leu Gly Thr Thr Gly Asp Thr Val Phe Leu Asn Cys Thr
  35                  40                  45                  50

 gtg ctt gga gac ggt ccc cct gga ccc atc agg tgg ttc cag gga gct      847
 Val Leu Gly Asp Gly Pro Pro Gly Pro Ile Arg Trp Phe Gln Gly Ala
                  55                  60                  65

 ggt ctg agc cgg gag gcc att tac aac ttt gga ggc atc tcc cac ccc      895
 Gly Leu Ser Arg Glu Ala Ile Tyr Asn Phe Gly Gly Ile Ser His Pro
              70                  75                  80

 aag gag aca gcg gtg cag gcc tcc aac aat gac ttc agc att ctt ctg      943
 Lys Glu Thr Ala Val Gln Ala Ser Asn Asn Asp Phe Ser Ile Leu Leu
          85                  90                  95

 caa aac gtc tcc agt gag gat gca ggc acc tat tac tgt gta aag ttt      991
 Gln Asn Val Ser Ser Glu Asp Ala Gly Thr Tyr Tyr Cys Val Lys Phe
     100                 105                 110

 cag agg aaa ccc aac agg caa tac ctg tct gga cag ggc acc agc ctg     1039
 Gln Arg Lys Pro Asn Arg Gln Tyr Leu Ser Gly Gln Gly Thr Ser Leu
 115                 120                 125                 130

 aaa gtg aaa gca aaa tct acc tct tcc aaa gag gca gaa ttc acc agt     1087
 Lys Val Lys Ala Lys Ser Thr Ser Ser Lys Glu Ala Glu Phe Thr Ser
                 135                 140                 145

 gaa cct gca act gag atg tct cca aca ggc ctc ctg gtt gtg ttc gca     1135
 Glu Pro Ala Thr Glu Met Ser Pro Thr Gly Leu Leu Val Val Phe Ala
             150                 155                 160

 cct gtg gtc ctg ggg ctg aag gca att acc ttg gct gca ctc cta ctg     1183
 Pro Val Val Leu Gly Leu Lys Ala Ile Thr Leu Ala Ala Leu Leu Leu
         165                 170                 175

 gcc ctg gct acc tct cgg agg agc cct ggg caa gaa gat gtc aag acc     1231
 Ala Leu Ala Thr Ser Arg Arg Ser Pro Gly Gln Glu Asp Val Lys Thr
     180                 185                 190

 aca ggc cca gca gga gcc atg aac acc tta gca tgg agc aag ggt caa     1279
 Thr Gly Pro Ala Gly Ala Met Asn Thr Leu Ala Trp Ser Lys Gly Gln
 195                 200                 205                 210

 gag tga                                                             1285
 Glu 






      <210> 217
      <211> 1679
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (440)..(1636)

      <400> 217
 gtcgtttccg gtgactgact ctctgtttcc attctggcaa agtggtttgc tcttttcact     60

 ctgctttggg tgttgaagga agacgagctt ctcacggagc ctctcttgag cctcttggca    120

 gtttccccct ctgtgcccct cacgtttcca ccagaaacgt gaaggcagag gccacagatt    180

 ctccctgagc cacctcactt ggaagcacca tgtccggatg agatcgcact tcctgcagtg    240

 ggcattagcc acgtccaggt agaaccaaac ctgttgcttt tgtatgttgg gtcaacttgg    300

 cctgacgttt cagaggtaga cacgagatag ggagttggaa gcaggatgtc cggatgagat    360

 cgcacttcct gcagagggca ttatcgtccg agaaacttag aagctgaagc cagagagcat    420

 ctcaaaggtt cctgataca atg gat ggt gtc act cca acc ctt tcg aca atc     472
                      Met Asp Gly Val Thr Pro Thr Leu Ser Thr Ile
                        1               5                  10

 aga ggg agg acc ttg gag tcc agc act ctg cat gtg act ccc cgc agc      520
 Arg Gly Arg Thr Leu Glu Ser Ser Thr Leu His Val Thr Pro Arg Ser
              15                  20                  25

 ctg gac aga aat aaa gac cag atc acc aac atc ttt tcc ggg ttt gcg      568
 Leu Asp Arg Asn Lys Asp Gln Ile Thr Asn Ile Phe Ser Gly Phe Ala
          30                  35                  40

 gga ctc ctc gcc atc ctc ctg gtc gtt gcg gtt ttc tgc atc ttg tgg      616
 Gly Leu Leu Ala Ile Leu Leu Val Val Ala Val Phe Cys Ile Leu Trp
      45                  50                  55

 aat tgg aat aaa cgg aag aag cga caa gtt cct tac ctc cga gtt acc      664
 Asn Trp Asn Lys Arg Lys Lys Arg Gln Val Pro Tyr Leu Arg Val Thr
  60                  65                  70                  75

 gtc atg ccc ttg ctg act ttg cca caa acc aga caa aga gcc aaa aat      712
 Val Met Pro Leu Leu Thr Leu Pro Gln Thr Arg Gln Arg Ala Lys Asn
                  80                  85                  90

 att tat gac atc ttg cct tgg cga cag gaa gac ctg ggg aga cat gag      760
 Ile Tyr Asp Ile Leu Pro Trp Arg Gln Glu Asp Leu Gly Arg His Glu
              95                 100                 105

 tcg agg agt atg cgc att ttc agt act gag agc ctc ctc tcc aga aat      808
 Ser Arg Ser Met Arg Ile Phe Ser Thr Glu Ser Leu Leu Ser Arg Asn
         110                 115                 120

 tct gag agc ccg gag cat gtg ccc tcc caa gca ggc aat gcc ttc cag      856
 Ser Glu Ser Pro Glu His Val Pro Ser Gln Ala Gly Asn Ala Phe Gln
     125                 130                 135

 gag cat aca gcc cac atc cat gcc aca gag tac gcg gtg ggt atc tat      904
 Glu His Thr Ala His Ile His Ala Thr Glu Tyr Ala Val Gly Ile Tyr
 140                 145                 150                 155

 gac aac gcc atg gtc ccc cag atg tgt ggg aac ctc act ccc tcg gca      952
 Asp Asn Ala Met Val Pro Gln Met Cys Gly Asn Leu Thr Pro Ser Ala
                 160                 165                 170

 cac tgc atc aat gtc aga gct tcc aga gac tgc gca agc att tct tca     1000
 His Cys Ile Asn Val Arg Ala Ser Arg Asp Cys Ala Ser Ile Ser Ser
             175                 180                 185

 gag gat tcg cat gat tat gtc aat gtc ccc aca gca gaa gag att gct     1048
 Glu Asp Ser His Asp Tyr Val Asn Val Pro Thr Ala Glu Glu Ile Ala
         190                 195                 200

 gag act cta gct tct acc aaa agc cct tcc aga aat ctc ttt gtt ctt     1096
 Glu Thr Leu Ala Ser Thr Lys Ser Pro Ser Arg Asn Leu Phe Val Leu
     205                 210                 215

 ccc agt acc cag aag ctg gag ttt act gag gaa aga gat gag ggc tgt     1144
 Pro Ser Thr Gln Lys Leu Glu Phe Thr Glu Glu Arg Asp Glu Gly Cys
 220                 225                 230                 235

 gga gat gct ggt gac tgc acc agt ttg tat tct cca gga gct gag gac     1192
 Gly Asp Ala Gly Asp Cys Thr Ser Leu Tyr Ser Pro Gly Ala Glu Asp
                 240                 245                 250

 agt gat tca ctc agc aat gga gaa ggt tct tct cag atc tca aat gac     1240
 Ser Asp Ser Leu Ser Asn Gly Glu Gly Ser Ser Gln Ile Ser Asn Asp
             255                 260                 265

 tat gtc aac atg aca ggg ttg gat ctc agt gcc atc cag gaa agg cag     1288
 Tyr Val Asn Met Thr Gly Leu Asp Leu Ser Ala Ile Gln Glu Arg Gln
         270                 275                 280

 ctc tgg gtg gct ttt cag tgc tgc aga gac tat gaa aat gtt cca gca     1336
 Leu Trp Val Ala Phe Gln Cys Cys Arg Asp Tyr Glu Asn Val Pro Ala
     285                 290                 295

 gca gat ccc agt gga agc cag cag cag gct gag aaa gat gtg cca tcc     1384
 Ala Asp Pro Ser Gly Ser Gln Gln Gln Ala Glu Lys Asp Val Pro Ser
 300                 305                 310                 315

 tca aac ata ggt cat gtc gag gac aag aca gat gat ccc ggg acc cat     1432
 Ser Asn Ile Gly His Val Glu Asp Lys Thr Asp Asp Pro Gly Thr His
                 320                 325                 330

 gtc caa tgt gtc aaa agg aca ttc ctt gct tca ggg gat tat gca gac     1480
 Val Gln Cys Val Lys Arg Thr Phe Leu Ala Ser Gly Asp Tyr Ala Asp
             335                 340                 345

 ttt cag cca ttc aca cag agt gag gac agt cag atg aaa cat aga gaa     1528
 Phe Gln Pro Phe Thr Gln Ser Glu Asp Ser Gln Met Lys His Arg Glu
         350                 355                 360

 gag atg tca aat gag gac tcc agt gac tat gaa aat gtg cta act gcc     1576
 Glu Met Ser Asn Glu Asp Ser Ser Asp Tyr Glu Asn Val Leu Thr Ala
     365                 370                 375

 aag tta gga ggc agg gac tct gag cag ggg cct ggc act cag ctc ctt     1624
 Lys Leu Gly Gly Arg Asp Ser Glu Gln Gly Pro Gly Thr Gln Leu Leu
 380                 385                 390                 395

 cct gat gaa tga aga cccaggtacc cagccataaa gccacattga gtagtctatc     1679
 Pro Asp Glu 






      <210> 218
      <211> 1572
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (1)..(1572)

      <400> 218
  atg ggt ggc tgt gtg gaa aga aat gca atg gca cat cgt gat tct gag      48
  Met Gly Gly Cys Val Glu Arg Asn Ala Met Ala His Arg Asp Ser Glu
    1               5                  10                  15

 atg aaa gaa gaa tgt cta agg gaa gac ctg aag ttt tac ttc atg agc       96
 Met Lys Glu Glu Cys Leu Arg Glu Asp Leu Lys Phe Tyr Phe Met Ser
              20                  25                  30

 cct tgt gaa aaa tac cga gcc aga cgc cag att ccg tgg aaa ctg ggt      144
 Pro Cys Glu Lys Tyr Arg Ala Arg Arg Gln Ile Pro Trp Lys Leu Gly
          35                  40                  45

 ttg cag att ttg aag ata gtc atg gtc acc aca cag tat cat cag cta      192
 Leu Gln Ile Leu Lys Ile Val Met Val Thr Thr Gln Tyr His Gln Leu
      50                  55                  60

 aag gac att acc ctg ggg acc ctt ggt tat gga gaa aat gaa gac aat      240
 Lys Asp Ile Thr Leu Gly Thr Leu Gly Tyr Gly Glu Asn Glu Asp Asn
  65                  70                  75                  80

 aga att ggc tta aaa gtc tgt aag cag cat tac aag aaa ggg acc atg      288
 Arg Ile Gly Leu Lys Val Cys Lys Gln His Tyr Lys Lys Gly Thr Met
                  85                  90                  95

 ttt cct tct aat gag aca ctg aat att gac aac gac gtt gag ctc gat      336
 Phe Pro Ser Asn Glu Thr Leu Asn Ile Asp Asn Asp Val Glu Leu Asp
             100                 105                 110

 tgt gtt caa tta gac ctt cag gac ctc tcc aag aag cct ccg gac tgg      384
 Cys Val Gln Leu Asp Leu Gln Asp Leu Ser Lys Lys Pro Pro Asp Trp
         115                 120                 125

 aag aac tca tca ttc ttc aga ctg gaa ttt tat cga tac gca gag atc      432
 Lys Asn Ser Ser Phe Phe Arg Leu Glu Phe Tyr Arg Tyr Ala Glu Ile
     130                 135                 140

 agg ggc ata ttt tct aag tcc aag tat agg ttg cca att ttc tgt gaa      480
 Arg Gly Ile Phe Ser Lys Ser Lys Tyr Arg Leu Pro Ile Phe Cys Glu
 145                 150                 155                 160

 aag aaa cta acc ttt gtc aaa tat gtg att tgg aat atc att ata aag      528
 Lys Lys Leu Thr Phe Val Lys Tyr Val Ile Trp Asn Ile Ile Ile Lys
                 165                 170                 175

 atc aaa atg atg gaa att tcc aag cta gtc agt caa atg cat ttc cag      576
 Ile Lys Met Met Glu Ile Ser Lys Leu Val Ser Gln Met His Phe Gln
             180                 185                 190

 aac act cag aaa aat gct cag tat gtc ctg gtg ttt gat gca ttt gtc      624
 Asn Thr Gln Lys Asn Ala Gln Tyr Val Leu Val Phe Asp Ala Phe Val
         195                 200                 205

 att gtg att tgc ttg gca tct ctt att ctg tgt aca aga tcc att gtt      672
 Ile Val Ile Cys Leu Ala Ser Leu Ile Leu Cys Thr Arg Ser Ile Val
     210                 215                 220

 ctt gct cta agg tta cgg aag gtg agg ggg ctc ata ttt gga gca cgc      720
 Leu Ala Leu Arg Leu Arg Lys Val Arg Gly Leu Ile Phe Gly Ala Arg
 225                 230                 235                 240

 act ctg gag ccg gcc tgc ctg gac acg gat cct ggc tta gcc tct cgg      768
 Thr Leu Glu Pro Ala Cys Leu Asp Thr Asp Pro Gly Leu Ala Ser Arg
                 245                 250                 255

 tgc ctc agt tcc ctt ctc tgg gtg ata gac ctg ctc gta cct gct tca      816
 Cys Leu Ser Ser Leu Leu Trp Val Ile Asp Leu Leu Val Pro Ala Ser
             260                 265                 270

 ttg ggt tgt tat cgg aat gga tgt gtt ggt aat atg aaa agt att tgg      864
 Leu Gly Cys Tyr Arg Asn Gly Cys Val Gly Asn Met Lys Ser Ile Trp
         275                 280                 285

 aat gta ctg tgt gtt agc tat gac aag aac ctg ctg gag tta ccg cgt      912
 Asn Val Leu Cys Val Ser Tyr Asp Lys Asn Leu Leu Glu Leu Pro Arg
     290                 295                 300

 acg tat ttc ata ttt gag aga ttt cta aat ttc ttc ctg gag aag tac      960
 Thr Tyr Phe Ile Phe Glu Arg Phe Leu Asn Phe Phe Leu Glu Lys Tyr
 305                 310                 315                 320

 aag cgg cct gtg tgt gac acc gac cag tgg gag ttc atc aac ggc tgg     1008
 Lys Arg Pro Val Cys Asp Thr Asp Gln Trp Glu Phe Ile Asn Gly Trp
                 325                 330                 335

 tat gtc ctg gtg att atc agc gac cta atg aca atc att ggc tcc ata     1056
 Tyr Val Leu Val Ile Ile Ser Asp Leu Met Thr Ile Ile Gly Ser Ile
             340                 345                 350

 tta aaa atg gaa atc aaa gca aag gtg ctg att tta aca atg cag gcc     1104
 Leu Lys Met Glu Ile Lys Ala Lys Val Leu Ile Leu Thr Met Gln Ala
         355                 360                 365

 tca ctg cca aaa gtt ctt cgg ttt tgt gct tgt gct ggt atg att tat     1152
 Ser Leu Pro Lys Val Leu Arg Phe Cys Ala Cys Ala Gly Met Ile Tyr
     370                 375                 380

 ctg ggt tac aca ttc tgt ggc tgg att gtc tta gga cca tac cat gac     1200
 Leu Gly Tyr Thr Phe Cys Gly Trp Ile Val Leu Gly Pro Tyr His Asp
 385                 390                 395                 400

 aag gat ata gaa ttt gaa aat ctg aac aca gtt gct gag tgt ctg ttt     1248
 Lys Asp Ile Glu Phe Glu Asn Leu Asn Thr Val Ala Glu Cys Leu Phe
                 405                 410                 415

 tct ctg gtc aac ggt gat gac atg ttt gca acc ttt gcc caa atc cag     1296
 Ser Leu Val Asn Gly Asp Asp Met Phe Ala Thr Phe Ala Gln Ile Gln
             420                 425                 430

 cag aag agc atc ttg gtg tgg ctg ttc agt cgt ctg tat tta tat tcc     1344
 Gln Lys Ser Ile Leu Val Trp Leu Phe Ser Arg Leu Tyr Leu Tyr Ser
         435                 440                 445

 ttc atc agc ctt ttt ata tat atg att ctc agt ctt ttt att gca ctt     1392
 Phe Ile Ser Leu Phe Ile Tyr Met Ile Leu Ser Leu Phe Ile Ala Leu
     450                 455                 460

 att aca gat tct tat gac acc att aag tat gtg gta caa gca atc ttt     1440
 Ile Thr Asp Ser Tyr Asp Thr Ile Lys Tyr Val Val Gln Ala Ile Phe
 465                 470                 475                 480

 ctt gat gag agc agg aaa ctt cct tgc gaa gag gct gtc caa gtg ctt     1488
 Leu Asp Glu Ser Arg Lys Leu Pro Cys Glu Glu Ala Val Gln Val Leu
                 485                 490                 495

 gct tat ccg tgc aca cca gta gct ctt cct tgc cta gct gtg ctt tgc     1536
 Ala Tyr Pro Cys Thr Pro Val Ala Leu Pro Cys Leu Ala Val Leu Cys
             500                 505                 510

 ctg ttg ttc gtc agg aca tgt aga gaa atg gtc tag                     1572
 Leu Leu Phe Val Arg Thr Cys Arg Glu Met Val 
         515                 520





      <210> 219
      <211> 1110
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (202)..(600)

      <400> 219
 tcgggcgaac caaacttacg gctaggtacg aggctgggtg ttgggtcttc agtgcgccca     60

 ggccggcggg gcgcgctccg gcggctcctg tcagcggcgg gtgcggcgga tcccagggca    120

 gccttcgggc ggcggcgctg cctggtgcgt cgcggcgtgg tcctccggcg gctgtccggg    180

 gcggtaggag ttggctgcgg g  atg tgc tca gcc ggg gag ctg ctg cgg ggc     231
                          Met Cys Ser Ala Gly Glu Leu Leu Arg Gly
                            1               5                  10

 ggc gac ggc ggg gaa cgc gac gag gac ggg gac gcg ctg gcg gag cgg      279
 Gly Asp Gly Gly Glu Arg Asp Glu Asp Gly Asp Ala Leu Ala Glu Arg
                  15                  20                  25

 gag gcg gca ggg acc gag tgg gat ccc ggg gcg agc ccg cgg cgg cgc      327
 Glu Ala Ala Gly Thr Glu Trp Asp Pro Gly Ala Ser Pro Arg Arg Arg
              30                  35                  40

 gga cag cgg ccg aag gag agc gag cag gat gtt gaa gac tca cag aac      375
 Gly Gln Arg Pro Lys Glu Ser Glu Gln Asp Val Glu Asp Ser Gln Asn
          45                  50                  55

 cac act ggt gag ccg gtt gga gat gac tac aag aaa atg gga aca ctt      423
 His Thr Gly Glu Pro Val Gly Asp Asp Tyr Lys Lys Met Gly Thr Leu
      60                  65                  70

 ttt ggt gaa ctg aac aaa aac ctt atc aac atg ggc ttc aca agg atg      471
 Phe Gly Glu Leu Asn Lys Asn Leu Ile Asn Met Gly Phe Thr Arg Met
  75                  80                  85                  90

 tat ttt gga gaa cga ata gtg gaa cca gta ata gtc att ttc ttt tgg      519
 Tyr Phe Gly Glu Arg Ile Val Glu Pro Val Ile Val Ile Phe Phe Trp
                  95                 100                 105

 gtt atg ctg tgg ttc ctt ggc ctg caa gcc ctt gga cta gtt gct gtt      567
 Val Met Leu Trp Phe Leu Gly Leu Gln Ala Leu Gly Leu Val Ala Val
             110                 115                 120

 ctt tgc ctt gtt att att tat gtg caa cag taa aacatggc cgaatttgaa      618
 Leu Cys Leu Val Ile Ile Tyr Val Gln Gln 
         125                 130

 aaaaaaaaaa aaaaaaaaaa cccaggggcc tcaaatgccg gggtccggaa aaaacgggtt    678

 atgaattgcg ccattggcca aaaccgtgtt ctctgaccca agttttcttg tcccaacggg    738

 gaaaactgcc ggggctcact taggggagcg gataaattcg ataaccccgg ttacctgtaa    798

 ttcacgaaca aggaccacgc agaaataaat cgacgactaa aaagaggacg aaaacgggga    858

 cacaaacaag aaaaattttg agaagcacat ttaatgcagg gaaaataaac gtgtgttagt    918

 aaaaaaaaaa agaacaccga taacaaagag cagagagagt ataagcacga ccaagaaaag    978

 aaagcaaaca ttattagcaa gaaagagacg tctcgagaag agcaagcaag cgagcaacaa   1038

 gacacatagt acagaggcac agagccgtca aaatagaaaa taatcagcaa cgaagaacac   1098

 aggtactaca gt                                                       1110




      <210> 220
      <211> 3899
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (118)..(3750)

      <400> 220
 ctcctcagcc agaaagcgca gttttgccag gagcttcttg gccagtgcca ccttcttttg     60

 cacattgcgc cgtctcaggc cgcgtagaag tcgcagtcct tgcttagcca aaaggtt       117                                                                 
 atg acc cgg ccc aat gcc ctg gat cga tgc cga ggg aaa ctc ctg gtg      165
 Met Thr Arg Pro Asn Ala Leu Asp Arg Cys Arg Gly Lys Leu Leu Val
   1               5                  10                  15

 cac agc ctg aac ctt ttg gct aag caa gga ctg cga ctt cta cgc ggc      213
 His Ser Leu Asn Leu Leu Ala Lys Gln Gly Leu Arg Leu Leu Arg Gly
              20                  25                  30

 ctg aga cgg cgc aat gtg caa aag aag gtg gca ctg gcc aag aag ctc      261
 Leu Arg Arg Arg Asn Val Gln Lys Lys Val Ala Leu Ala Lys Lys Leu
          35                  40                  45

 ctg gca aaa ctg cgc ttt ctg gct gag gag ccc cag cca ccc ctc ccc      309
 Leu Ala Lys Leu Arg Phe Leu Ala Glu Glu Pro Gln Pro Pro Leu Pro
      50                  55                  60

 gat gtg ctg gtc tgg atg ctc agc ggg cag cgc cgt gtg gcc tgg gcc      357
 Asp Val Leu Val Trp Met Leu Ser Gly Gln Arg Arg Val Ala Trp Ala
  65                  70                  75                  80

 cgg atc cct gcc cag gat gtg ctg ttc tct gtg gtt gag gag gaa cgg      405
 Arg Ile Pro Ala Gln Asp Val Leu Phe Ser Val Val Glu Glu Glu Arg
                  85                  90                  95

 ggc cga gac tgt ggg aag atc cag agt cta atg ctc acg gca ccc ggg      453
 Gly Arg Asp Cys Gly Lys Ile Gln Ser Leu Met Leu Thr Ala Pro Gly
             100                 105                 110

 gca gcc cct ggt gag gtc tgt gcc aag ctg gag ctc ttc ctg cgg ctg      501
 Ala Ala Pro Gly Glu Val Cys Ala Lys Leu Glu Leu Phe Leu Arg Leu
         115                 120                 125

 ggc ctg ggc aag caa gcc aag gcc tgc acc tct gag ctg ccc ccg gat      549
 Gly Leu Gly Lys Gln Ala Lys Ala Cys Thr Ser Glu Leu Pro Pro Asp
     130                 135                 140

 ttg ctg ccc gag ccc tca gcc ggg ctg ccc tcc agc cta cac cgg gac      597
 Leu Leu Pro Glu Pro Ser Ala Gly Leu Pro Ser Ser Leu His Arg Asp
 145                 150                 155                 160

 gac ttt agc tac ttc caa ctc cgg gct cac ttg tac cag gcc cgg ggt      645
 Asp Phe Ser Tyr Phe Gln Leu Arg Ala His Leu Tyr Gln Ala Arg Gly
                 165                 170                 175

 gtg ttg gct gca gat gac agt ggc ctc tcg gac ccc ttt gct cga gtc      693
 Val Leu Ala Ala Asp Asp Ser Gly Leu Ser Asp Pro Phe Ala Arg Val
             180                 185                 190

 ctc atc tct acc cag tgt cag acc aca cgg gtc ctg gag cag acg ctg      741
 Leu Ile Ser Thr Gln Cys Gln Thr Thr Arg Val Leu Glu Gln Thr Leu
         195                 200                 205

 agc cct ctg tgg gat gaa ctc ctg gta ttt gag cag ttg atc gtg gat      789
 Ser Pro Leu Trp Asp Glu Leu Leu Val Phe Glu Gln Leu Ile Val Asp
     210                 215                 220

 ggg agg agg gag cac ctg cag gag gag cct cca tta gtg atc atc aat      837
 Gly Arg Arg Glu His Leu Gln Glu Glu Pro Pro Leu Val Ile Ile Asn
 225                 230                 235                 240

 gta ttt gac cac aat aag ttt ggc ccc ccc gtg ttc ctg ggc agg gca      885
 Val Phe Asp His Asn Lys Phe Gly Pro Pro Val Phe Leu Gly Arg Ala
                 245                 250                 255

 ctg gcc gcc cca agg gta aag ctg atg gag gac cca tac caa cgc cca      933
 Leu Ala Ala Pro Arg Val Lys Leu Met Glu Asp Pro Tyr Gln Arg Pro
             260                 265                 270

 gag ttg cag ttc ttc ccc ctg agg aag gga ccc tgg gca gcc gga gag      981
 Glu Leu Gln Phe Phe Pro Leu Arg Lys Gly Pro Trp Ala Ala Gly Glu
         275                 280                 285

 ctc att gcc gcc ttt caa ctc att gaa cta gac tac agt ggc cga ctt     1029
 Leu Ile Ala Ala Phe Gln Leu Ile Glu Leu Asp Tyr Ser Gly Arg Leu
     290                 295                 300

 gag ccc tca gtg ccc agt gag gtg gag ccc cag gat ctg gca ccc ctg     1077
 Glu Pro Ser Val Pro Ser Glu Val Glu Pro Gln Asp Leu Ala Pro Leu
 305                 310                 315                 320

 gtt gag ccc cac tct gga cgc ctg tcc ctt cca ccc aac gtg tgc cca     1125
 Val Glu Pro His Ser Gly Arg Leu Ser Leu Pro Pro Asn Val Cys Pro
                 325                 330                 335

 gtg ctc agg gag ttc cgt gtt gag gtg ctg ttc tgg ggt ctt agg gga     1173
 Val Leu Arg Glu Phe Arg Val Glu Val Leu Phe Trp Gly Leu Arg Gly
             340                 345                 350

 ctt ggt cgt gtg cat ctg ctc gag gtg gag cag ccc cag gtt gta ctg     1221
 Leu Gly Arg Val His Leu Leu Glu Val Glu Gln Pro Gln Val Val Leu
         355                 360                 365

 gag gtg gct ggg caa ggt gtg gag tct gag gtc ctg gcc agc tac cgt     1269
 Glu Val Ala Gly Gln Gly Val Glu Ser Glu Val Leu Ala Ser Tyr Arg
     370                 375                 380

 gag agc ccc aat ttc act gag ctt gtc agg cat ctg aca gtg gtc ttc     1317
 Glu Ser Pro Asn Phe Thr Glu Leu Val Arg His Leu Thr Val Val Phe
 385                 390                 395                 400

 aaa gac aca gct cct ctc ttc cac ccc cag gac ttg ccg gag cag cct     1365
 Lys Asp Thr Ala Pro Leu Phe His Pro Gln Asp Leu Pro Glu Gln Pro
                 405                 410                 415

 tac ttg cag cct cca ctc agc atc ttg gtg att gag cgc cgg gcc ttt     1413
 Tyr Leu Gln Pro Pro Leu Ser Ile Leu Val Ile Glu Arg Arg Ala Phe
             420                 425                 430

 ggc cac aca gtc ctt gtg ggt tcc cac att gtc ccc cac atg ctg cga     1461
 Gly His Thr Val Leu Val Gly Ser His Ile Val Pro His Met Leu Arg
         435                 440                 445

 ttc aca ttt cgg ggt cat gag gat cct cct gag gag gaa gga gag atg     1509
 Phe Thr Phe Arg Gly His Glu Asp Pro Pro Glu Glu Glu Gly Glu Met
     450                 455                 460

 gag gag aca ggg gat atg atg ccc aag gga cct caa gga cag aag tcc     1557
 Glu Glu Thr Gly Asp Met Met Pro Lys Gly Pro Gln Gly Gln Lys Ser
 465                 470                 475                 480

 ctg gat ccc ttc ttg gct gaa gcg ggt ata tcc aga cag ctc ctg aag     1605
 Leu Asp Pro Phe Leu Ala Glu Ala Gly Ile Ser Arg Gln Leu Leu Lys
                 485                 490                 495

 cct cct ctg aag aag ctc cca cta gga ggc ctc cta aat caa ggc cct     1653
 Pro Pro Leu Lys Lys Leu Pro Leu Gly Gly Leu Leu Asn Gln Gly Pro
             500                 505                 510

 ggg ctg gag gaa gac atc cca gat cca gag gag ctc gac tgg ggg tcc     1701
 Gly Leu Glu Glu Asp Ile Pro Asp Pro Glu Glu Leu Asp Trp Gly Ser
         515                 520                 525

 aag tac tat gcg tcg ctg cag gag ctc cag ggg cag cac aac ttt gat     1749
 Lys Tyr Tyr Ala Ser Leu Gln Glu Leu Gln Gly Gln His Asn Phe Asp
     530                 535                 540

 gaa gat gaa atg gat gat cct gga gat tca gat ggg gtc aac ctc att     1797
 Glu Asp Glu Met Asp Asp Pro Gly Asp Ser Asp Gly Val Asn Leu Ile
 545                 550                 555                 560

 tct atg gtt ggg gag atc caa gac cag ggt gag gct gaa gtc aaa ggc     1845
 Ser Met Val Gly Glu Ile Gln Asp Gln Gly Glu Ala Glu Val Lys Gly
                 565                 570                 575

 act gtg tcc cca aaa aaa gca gtt gcc acc ctg aag atc tac aac agg     1893
 Thr Val Ser Pro Lys Lys Ala Val Ala Thr Leu Lys Ile Tyr Asn Arg
             580                 585                 590

 tcc ctg gag gaa gaa ttt aac cac ttt gaa gac tgg ctg aat gtg ttt     1941
 Ser Leu Glu Glu Glu Phe Asn His Phe Glu Asp Trp Leu Asn Val Phe
         595                 600                 605

 cct ctg tac cga ggg caa ggg ggc cag gat gga ggt gga gaa gag gaa     1989
 Pro Leu Tyr Arg Gly Gln Gly Gly Gln Asp Gly Gly Gly Glu Glu Glu
     610                 615                 620

 gga tct gga cac ctt gtg ggc aag ttc aag ggc tcc ttc ctc att tac     2037
 Gly Ser Gly His Leu Val Gly Lys Phe Lys Gly Ser Phe Leu Ile Tyr
 625                 630                 635                 640

 cct gaa tca gag gca gtg ttg ttc tct gag ccc cag atc tcc cgg ggg     2085
 Pro Glu Ser Glu Ala Val Leu Phe Ser Glu Pro Gln Ile Ser Arg Gly
                 645                 650                 655

 atc cca cag aac cgg ccc atc aag ctc ctg gtc aga gtg tat gtt gta     2133
 Ile Pro Gln Asn Arg Pro Ile Lys Leu Leu Val Arg Val Tyr Val Val
             660                 665                 670

 aag gct acc aac ctg gct cct gca gac ccc aat ggc aaa gca gac cct     2181
 Lys Ala Thr Asn Leu Ala Pro Ala Asp Pro Asn Gly Lys Ala Asp Pro
         675                 680                 685

 tac gtg gtg gtg agc gct ggc cgg gag cgg cag gac acc aag gaa cgc     2229
 Tyr Val Val Val Ser Ala Gly Arg Glu Arg Gln Asp Thr Lys Glu Arg
     690                 695                 700

 tac atc ccc aag cag ctc aac ccc atc ttt gga gag atc ctg gag cta     2277
 Tyr Ile Pro Lys Gln Leu Asn Pro Ile Phe Gly Glu Ile Leu Glu Leu
 705                 710                 715                 720

 agc atc tct ctc cca gct gag acg gag ctg acg gtc gcc gta ttt gat     2325
 Ser Ile Ser Leu Pro Ala Glu Thr Glu Leu Thr Val Ala Val Phe Asp
                 725                 730                 735

 cat gac ctc gtg ggt tct gac gac ctc atc ggg gag acc cac att gat     2373
 His Asp Leu Val Gly Ser Asp Asp Leu Ile Gly Glu Thr His Ile Asp
             740                 745                 750

 ctg gaa aac cga ttc tat agc cac cac aga gca aac tgt ggg ctg gcc     2421
 Leu Glu Asn Arg Phe Tyr Ser His His Arg Ala Asn Cys Gly Leu Ala
         755                 760                 765

 tcc cag tat gaa gta gat ggt tac aat gcc tgg cgt gat gca ttc tgg     2469
 Ser Gln Tyr Glu Val Asp Gly Tyr Asn Ala Trp Arg Asp Ala Phe Trp
     770                 775                 780

 cct tcg cag atc ctg gcg ggg ctg tgc caa cgc tgt ggc ctc cct gcc     2517
 Pro Ser Gln Ile Leu Ala Gly Leu Cys Gln Arg Cys Gly Leu Pro Ala
 785                 790                 795                 800

 cct gaa tac cga gcc ggt gct gtc aag gtg ggc agc aaa gtc ttc ctg     2565
 Pro Glu Tyr Arg Ala Gly Ala Val Lys Val Gly Ser Lys Val Phe Leu
                 805                 810                 815

 aca cca ccg gag acc ctg ccc cca ggc agc agc agc ccc aca gtg gcg     2613
 Thr Pro Pro Glu Thr Leu Pro Pro Gly Ser Ser Ser Pro Thr Val Ala
             820                 825                 830

 agc ggg gac cct gaa gag gcc cag gca ttg ctt gtg ctg cgg cgc tgg     2661
 Ser Gly Asp Pro Glu Glu Ala Gln Ala Leu Leu Val Leu Arg Arg Trp
         835                 840                 845

 cag gaa atg ccg ggt ttt ggg atc cag ctg gta ccc gag cat gta gaa     2709
 Gln Glu Met Pro Gly Phe Gly Ile Gln Leu Val Pro Glu His Val Glu
     850                 855                 860

 acc agg cct ctc tac cat ccc cac agc cca ggg ctg cta cag gga tct     2757
 Thr Arg Pro Leu Tyr His Pro His Ser Pro Gly Leu Leu Gln Gly Ser
 865                 870                 875                 880

 ctt cac atg tgg att gac atc ttt cct caa gat gtg cct gct cca ccc     2805
 Leu His Met Trp Ile Asp Ile Phe Pro Gln Asp Val Pro Ala Pro Pro
                 885                 890                 895

 cca gtt gac atc aag cct cgg cag cca atc agc tat gag ctc aga gtt     2853
 Pro Val Asp Ile Lys Pro Arg Gln Pro Ile Ser Tyr Glu Leu Arg Val
             900                 905                 910

 gtc atc tgg aac acg gag gat gtg gtt ctg gat gac gag aat cca ctc     2901
 Val Ile Trp Asn Thr Glu Asp Val Val Leu Asp Asp Glu Asn Pro Leu
         915                 920                 925

 acc gga gag atg tcg agt gac atc tat gtg aag agc tgg gtg aag ggg     2949
 Thr Gly Glu Met Ser Ser Asp Ile Tyr Val Lys Ser Trp Val Lys Gly
     930                 935                 940

 ttg gag cat gac aag cag gag aca gac gtt cac ttc aac tcc ctg act     2997
 Leu Glu His Asp Lys Gln Glu Thr Asp Val His Phe Asn Ser Leu Thr
 945                 950                 955                 960

 ggg gag ggg aac ttc aat tgg cgc ttt gtg ttc cgc ttt gac tac ctg     3045
 Gly Glu Gly Asn Phe Asn Trp Arg Phe Val Phe Arg Phe Asp Tyr Leu
                 965                 970                 975

 ccc acg gag cgg gag gtg agc gtc tgg cgc agg tct gga ccc ttt gcc     3093
 Pro Thr Glu Arg Glu Val Ser Val Trp Arg Arg Ser Gly Pro Phe Ala
             980                 985                 990

 ctg gag gag gcg gag ttc cgg cag cct gca gtg ctg gtc ctg cag gtc     3141
 Leu Glu Glu Ala Glu Phe Arg Gln Pro Ala Val Leu Val Leu Gln Val
         995                1000                1005

 tgg gac tat gac cgc atc tct gcc aat gac ttc ctt gga tcc ctg gag     3189
 Trp Asp Tyr Asp Arg Ile Ser Ala Asn Asp Phe Leu Gly Ser Leu Glu
    1010                1015                1020

 ttg cag cta cca gac atg gtg cgt ggg gcc cgg ggc ccc gag ctc tgc     3237
 Leu Gln Leu Pro Asp Met Val Arg Gly Ala Arg Gly Pro Glu Leu Cys
1025                1030                1035                1040

 tct gtg cag ctg gcc cgc aat ggg gcc ggg ccg agg tgc aat ctg ttt     3285
 Ser Val Gln Leu Ala Arg Asn Gly Ala Gly Pro Arg Cys Asn Leu Phe
                1045                1050                1055

 cgc tgc cgc cgc ctg agg ggc tgg tgg ccg gta gtg aag ctg aag gag     3333
 Arg Cys Arg Arg Leu Arg Gly Trp Trp Pro Val Val Lys Leu Lys Glu
            1060                1065                1070

 gca gag gac gtg gag cgg gag gcg cag gag gct cag gct ggc aag aag     3381
 Ala Glu Asp Val Glu Arg Glu Ala Gln Glu Ala Gln Ala Gly Lys Lys
        1075                1080                1085

 aag cga aag cag agg agg agg aag ggc cgg cca gaa gac ctg gag ttc     3429
 Lys Arg Lys Gln Arg Arg Arg Lys Gly Arg Pro Glu Asp Leu Glu Phe
    1090                1095                1100

 aca gac atg ggt ggc aat gtg tac atc ctc acg ggc aag gtg gag gca     3477
 Thr Asp Met Gly Gly Asn Val Tyr Ile Leu Thr Gly Lys Val Glu Ala
1105                1110                1115                1120

 gag ttt gag ctg ctg act gtg gag gag gcc gag aaa cgg cca gtg ggg     3525
 Glu Phe Glu Leu Leu Thr Val Glu Glu Ala Glu Lys Arg Pro Val Gly
                1125                1130                1135

 aag ggg cgg aag cag cca gag cct ctg gag aaa ccc agc cgc ccc aaa     3573
 Lys Gly Arg Lys Gln Pro Glu Pro Leu Glu Lys Pro Ser Arg Pro Lys
            1140                1145                1150

 act tcc ttc aac tgg ttt gtg aac ccg ctg aag acc ttt gtc ttc ttc     3621
 Thr Ser Phe Asn Trp Phe Val Asn Pro Leu Lys Thr Phe Val Phe Phe
        1155                1160                1165

 atc tgg cgc cgg tac tgg cgc acc ctg gtg ctg ctg cta ctg gtg ctg     3669
 Ile Trp Arg Arg Tyr Trp Arg Thr Leu Val Leu Leu Leu Leu Val Leu
    1170                1175                1180

 ctc acc gtc ttc ctc ctc ctg gtc ttc tac acc atc cct ggc cag atc     3717
 Leu Thr Val Phe Leu Leu Leu Val Phe Tyr Thr Ile Pro Gly Gln Ile
1185                1190                1195                1200

 agc cag gtc atc ttc cgt ccc ctc cac aag tga ctctcgct gaccttggac     3768
 Ser Gln Val Ile Phe Arg Pro Leu His Lys 
                1205                1210

 actcacccag ggtgccaacc cttcaatgcc tgctcctgga agtctttctt acccatgtga   3828

 gctaccccag agtctagtgc ttcctctgaa taaacctatc acagccaaaa aaaaaaaaaa   3888

 aaaaaacgaa g                                                        3899




      <210> 221
      <211> 963
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (250)..(963)

      <400> 221
 ccctgtcccg acccccggcc tggcccactc cgaccctacc cggccgaagg gttccgctgg     60

 acacgcaggc ggcctccgga gcagcccaag cccatgaggg ccgcgcgccc ggccgccggt    120

 gctgacgaga cggagctcct ggcccccgag gaggagcaga ggatcaatgc ggttcaagaa    180

 tcgattccag cgtgctatcg taagcacttt gggaagccag aggcagactt taagctggga    240

 ttggggttc    atg aac cat cga gct cca gcc aat ggc cgc tac aag cca     288
              Met Asn His Arg Ala Pro Ala Asn Gly Arg Tyr Lys Pro
                1               5                  10

 act tgc tat gaa cat gct gct aac tgt tac aca cac gca ttc ctc att      336
 Thr Cys Tyr Glu His Ala Ala Asn Cys Tyr Thr His Ala Phe Leu Ile
      15                  20                  25

 gtt ccg gcc atc gtg ggc agt gcc ctc ctc cat cgg ctg tct gat gac      384
 Val Pro Ala Ile Val Gly Ser Ala Leu Leu His Arg Leu Ser Asp Asp
  30                  35                  40                  45

 tgc tgg gaa aag ata aca gca tgg att tat gga atg gga ctc tgt gcc      432
 Cys Trp Glu Lys Ile Thr Ala Trp Ile Tyr Gly Met Gly Leu Cys Ala
                  50                  55                  60

 ctc ttc atc gtt tct aca gta ttt cac att gta tca tgg aaa aag agc      480
 Leu Phe Ile Val Ser Thr Val Phe His Ile Val Ser Trp Lys Lys Ser
              65                  70                  75

 cac tta agg tta aat ctt cgt gaa ctt gga ccc ctg gca tct cat atg      528
 His Leu Arg Leu Asn Leu Arg Glu Leu Gly Pro Leu Ala Ser His Met
          80                  85                  90

 cgt tgg ttt atc tgg ctc atg gca gct gga gga acc att tat gta ttt      576
 Arg Trp Phe Ile Trp Leu Met Ala Ala Gly Gly Thr Ile Tyr Val Phe
      95                 100                 105

 ctc tac cat gaa aaa tat aag gtg gtt gaa ctc ttt ttc tat ctc aca      624
 Leu Tyr His Glu Lys Tyr Lys Val Val Glu Leu Phe Phe Tyr Leu Thr
 110                 115                 120                 125

 atg gga ttc tct cca gcc ttg gtg gtg aca tca atg tac agg act gtg      672
 Met Gly Phe Ser Pro Ala Leu Val Val Thr Ser Met Tyr Arg Thr Val
                 130                 135                 140

 atc ctt gaa gga aga gaa acc aag aaa atg agc ttt gaa ttc acc cca      720
 Ile Leu Glu Gly Arg Glu Thr Lys Lys Met Ser Phe Glu Phe Thr Pro
             145                 150                 155

 gta gtt tcc ctg gag aca ctt tcc aaa cag caa caa aag gag aac aac      768
 Val Val Ser Leu Glu Thr Leu Ser Lys Gln Gln Gln Lys Glu Asn Asn
         160                 165                 170

 acc gat gga ctt cag gaa ctt gcc tgt ggg ggc tta att tat tgc ttg      816
 Thr Asp Gly Leu Gln Glu Leu Ala Cys Gly Gly Leu Ile Tyr Cys Leu
     175                 180                 185

 gga gtt gtg ttc ttc aag agt gat ggc atc att cca ttt gcc cac gcc      864
 Gly Val Val Phe Phe Lys Ser Asp Gly Ile Ile Pro Phe Ala His Ala
 190                 195                 200                 205

 atc tgg cac ctg ttt gtg gcc acg gca gct gca gtg cat tac tac gcc      912
 Ile Trp His Leu Phe Val Ala Thr Ala Ala Ala Val His Tyr Tyr Ala
                 210                 215                 220

 att tgg aaa tac ctt tac cga agt cct acg gac ttt atg cgg cat tta      960
 Ile Trp Lys Tyr Leu Tyr Arg Ser Pro Thr Asp Phe Met Arg His Leu
             225                 230                 235

 tga                                                                  963
 






      <210> 222
      <211> 1368
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (232)..(1368)

      <400> 222
 gagaggggac accaagtcct ggggcctggc caatagacaa ggacacaggg atctttgata     60

 aacagggttt ggctttcttc tcagagttgt gatttcttgc ttggttccca ggagcccttg    120

 ggaagctgga cctggaacac tggagcctga tattctctgt tgtggggaat ccaaggtgaa    180

 gtgtggccac gccttgggct gttctggaga gctacagcgg gagagaagtt c atg gag     237
                                                          Met Glu
                                                            1

 ttc tgt gac aca gtg act ggc cag gaa gcc cag agc aag agg cga caa      285
 Phe Cys Asp Thr Val Thr Gly Gln Glu Ala Gln Ser Lys Arg Arg Gln
           5                  10                  15

 gac aca gcc aga tca ggg aga agg cct gcc agc aat cca gac atc cac      333
 Asp Thr Ala Arg Ser Gly Arg Arg Pro Ala Ser Asn Pro Asp Ile His
      20                  25                  30

 gcc gtg agc ttt ctg caa gcc ctc agg cag ggc tcc gga agg cca cct      381
 Ala Val Ser Phe Leu Gln Ala Leu Arg Gln Gly Ser Gly Arg Pro Pro
  35                  40                  45                  50

 ctg gga tgg tgg ggt cct aca ggt agc tct act aga aat atg gag agc      429
 Leu Gly Trp Trp Gly Pro Thr Gly Ser Ser Thr Arg Asn Met Glu Ser
                  55                  60                  65

 gga aac caa tca aca gtg act gaa ttt atc ttc act gga ttc cct cag      477
 Gly Asn Gln Ser Thr Val Thr Glu Phe Ile Phe Thr Gly Phe Pro Gln
              70                  75                  80

 ctt cag gat ggt agt ctc ctg tac ttc ttt cct tta ctt ttc atc tat      525
 Leu Gln Asp Gly Ser Leu Leu Tyr Phe Phe Pro Leu Leu Phe Ile Tyr
          85                  90                  95

 act ttt att atc att gat aac tta tta atc ttc tct gct gta agg ctg      573
 Thr Phe Ile Ile Ile Asp Asn Leu Leu Ile Phe Ser Ala Val Arg Leu
     100                 105                 110

 gac acc cat ctc cac aac ccc atg tat aat ttt atc agt ata ttt tcc      621
 Asp Thr His Leu His Asn Pro Met Tyr Asn Phe Ile Ser Ile Phe Ser
 115                 120                 125                 130

 ttt ctg gag atc tgg tac acc aca gcc acc att ccc aag atg ctc tcc      669
 Phe Leu Glu Ile Trp Tyr Thr Thr Ala Thr Ile Pro Lys Met Leu Ser
                 135                 140                 145

 aac ctc atc agt gaa aag aag gcc atc tca atg act ggc tgc atc ttg      717
 Asn Leu Ile Ser Glu Lys Lys Ala Ile Ser Met Thr Gly Cys Ile Leu
             150                 155                 160

 cag atg tat ttc ttc cac tca ctt gaa aac tca gag ggg atc ttg ctg      765
 Gln Met Tyr Phe Phe His Ser Leu Glu Asn Ser Glu Gly Ile Leu Leu
         165                 170                 175

 acc acc atg gcc att gac aga tac gtt gcc atc tgc aac cct ctt cgc      813
 Thr Thr Met Ala Ile Asp Arg Tyr Val Ala Ile Cys Asn Pro Leu Arg
     180                 185                 190

 tat caa atg atc atg acc ccc cgg ctc tgt gct caa ctc tct gca ggt      861
 Tyr Gln Met Ile Met Thr Pro Arg Leu Cys Ala Gln Leu Ser Ala Gly
 195                 200                 205                 210

 tcc tgc ctc ttc ggt ttc ctt atc ctg ctt ccc gag att gtg atg att      909
 Ser Cys Leu Phe Gly Phe Leu Ile Leu Leu Pro Glu Ile Val Met Ile
                 215                 220                 225

 tcc aca ctg cct ttc tgt ggg ccc aac caa atc cat cag atc ttc tgt      957
 Ser Thr Leu Pro Phe Cys Gly Pro Asn Gln Ile His Gln Ile Phe Cys
             230                 235                 240

 gac ttg gtc cct gtg cta agc ctg gcc tgt aca gac acg tcc atg att     1005
 Asp Leu Val Pro Val Leu Ser Leu Ala Cys Thr Asp Thr Ser Met Ile
         245                 250                 255

 ctg att gag gat gtg atc cat gct gtg gcc att gta ttc tct gtc ctg     1053
 Leu Ile Glu Asp Val Ile His Ala Val Ala Ile Val Phe Ser Val Leu
     260                 265                 270

 att att gcc ctt tct tat atc aga atc atc act gta atc ctg agg att     1101
 Ile Ile Ala Leu Ser Tyr Ile Arg Ile Ile Thr Val Ile Leu Arg Ile
 275                 280                 285                 290

 ccc tct gtt gaa ggc cgc cag aag gcc ttt tct acc tgt gcc gcc cat     1149
 Pro Ser Val Glu Gly Arg Gln Lys Ala Phe Ser Thr Cys Ala Ala His
                 295                 300                 305

 ctt agt gtc ttt ctg atg ttc tat ggc agt gta tcc ctc atg tac ctg     1197
 Leu Ser Val Phe Leu Met Phe Tyr Gly Ser Val Ser Leu Met Tyr Leu
             310                 315                 320

 cgt ttc tct gcc act ttc cca ccg att ttg gac aca gct gtt gca ctg     1245
 Arg Phe Ser Ala Thr Phe Pro Pro Ile Leu Asp Thr Ala Val Ala Leu
         325                 330                 335

 atg ttt gca gtt ctt gct ccc ttt ttc aac cct atc atc tat agc ttt     1293
 Met Phe Ala Val Leu Ala Pro Phe Phe Asn Pro Ile Ile Tyr Ser Phe
     340                 345                 350

 aga aat aag gac atg aag att gca att aaa aag ctt ttc tgc cct cag     1341
 Arg Asn Lys Asp Met Lys Ile Ala Ile Lys Lys Leu Phe Cys Pro Gln
 355                 360                 365                 370

 aag atg gtt aat tta tct gta gat taa                                 1368
 Lys Met Val Asn Leu Ser Val Asp 
                 375





      <210> 223
      <211> 1521
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (334)..(1521)

      <400> 223
 catgattttt aaagagcggg tggagcataa cgatttgagg cactgcgaca atgcagaatg     60

 gggagggttt ttggaaaatg tgactcactc accgttccga ccaaagggta aatgaaccca    120

 gcacctatgc tggcccggac atcactgata ggtaagatga agtcacttgg cacacctttt    180

 ttgtcaggtt ggtgagacag agaaagatcg gtctttgcca tgcagatggg caaatttcca    240

 aaaccctgta agaaaggaaa gaaaatgtgt tcactgatat agatgtgagt ctcctgtgtt    300

 tttcaatttg cactttatac agtctcggca gca atg gta tgc cag ctc aga tcg     354
                                      Met Val Cys Gln Leu Arg Ser
                                        1               5

 agg cac atg cag gag ctg ctt gtt act act tgt tca ctg aag aag caa      402
 Arg His Met Gln Glu Leu Leu Val Thr Thr Cys Ser Leu Lys Lys Gln
          10                  15                  20

 gaa gca tct aca aat ctg aag gac aaa aca tgg ttc aag cat ctg ggc      450
 Glu Ala Ser Thr Asn Leu Lys Asp Lys Thr Trp Phe Lys His Leu Gly
      25                  30                  35

 aca ggc ggg gag gca gct ctc ctg ctg aaa tcc tcc act tgg ccc atg      498
 Thr Gly Gly Glu Ala Ala Leu Leu Leu Lys Ser Ser Thr Trp Pro Met
  40                  45                  50                  55

 gcc ctc tgg tcc acc cgt ggc tcc aaa atg gtc tcc tgg tcc gtg ata      546
 Ala Leu Trp Ser Thr Arg Gly Ser Lys Met Val Ser Trp Ser Val Ile
                  60                  65                  70

 gca aag atc cag gaa ata tgg tgc gag gaa gat gag agg aag atg gtg      594
 Ala Lys Ile Gln Glu Ile Trp Cys Glu Glu Asp Glu Arg Lys Met Val
              75                  80                  85

 cga gag ttc ttg gcc gag ttc atg agc aca tat gtc atg atg gta ttc      642
 Arg Glu Phe Leu Ala Glu Phe Met Ser Thr Tyr Val Met Met Val Phe
          90                  95                 100

 ggc ctt ggt tct gtg gcc cat atg gtt cta aat aaa aca tat ggg agc      690
 Gly Leu Gly Ser Val Ala His Met Val Leu Asn Lys Thr Tyr Gly Ser
     105                 110                 115

 tac ctt ggt gtc aac ttg ggt ttt ggc ttc ggg gtc acc atg gga gtc      738
 Tyr Leu Gly Val Asn Leu Gly Phe Gly Phe Gly Val Thr Met Gly Val
 120                 125                 130                 135

 cac gtg gca ggc cgc atc tct gga gcc cac atg aat gca gct gtg acc      786
 His Val Ala Gly Arg Ile Ser Gly Ala His Met Asn Ala Ala Val Thr
                 140                 145                 150

 ttc act aac tgt gcg ctg ggc cgc gtg ccc tgg agg aag ttt cca gtc      834
 Phe Thr Asn Cys Ala Leu Gly Arg Val Pro Trp Arg Lys Phe Pro Val
             155                 160                 165

 cat gtg ctg ggg cag ttc ctg ggc tcc ttc ctg gca gct gcc acc atc      882
 His Val Leu Gly Gln Phe Leu Gly Ser Phe Leu Ala Ala Ala Thr Ile
         170                 175                 180

 tac agt ctc ttc tac agc aag tgt gct gcc tgg gag tgg ctg acc agg      930
 Tyr Ser Leu Phe Tyr Ser Lys Cys Ala Ala Trp Glu Trp Leu Thr Arg
     185                 190                 195

 atg ctc cag ctg tgt ctc ttc acc atc acg gac cag gag aac aac cca      978
 Met Leu Gln Leu Cys Leu Phe Thr Ile Thr Asp Gln Glu Asn Asn Pro
 200                 205                 210                 215

 gca ctg cca gga aca cac gcg ctg gtg ata agc atc ctc gtg gtc atc     1026
 Ala Leu Pro Gly Thr His Ala Leu Val Ile Ser Ile Leu Val Val Ile
                 220                 225                 230

 atc agg gtg tcc cat ggc ata aac aca gga tat gcc atc aat cca tcc     1074
 Ile Arg Val Ser His Gly Ile Asn Thr Gly Tyr Ala Ile Asn Pro Ser
             235                 240                 245

 cgg gac ccg ccc ccc agc atc ttc acc ttc att gct ggc tgg ggc aaa     1122
 Arg Asp Pro Pro Pro Ser Ile Phe Thr Phe Ile Ala Gly Trp Gly Lys
         250                 255                 260

 cag gtc ttc agc ctg ggg atg act cct ctg ctc aac cag tct tcg ccc     1170
 Gln Val Phe Ser Leu Gly Met Thr Pro Leu Leu Asn Gln Ser Ser Pro
     265                 270                 275

 aag gtg gat gag ggt gct gtc ctg ggc atc agc ccc ctc agc agg cct     1218
 Lys Val Asp Glu Gly Ala Val Leu Gly Ile Ser Pro Leu Ser Arg Pro
 280                 285                 290                 295

 ctg cct ctt gcc tgc agc gat ggg gag aac tgg tgg tgg gtg cca gtg     1266
 Leu Pro Leu Ala Cys Ser Asp Gly Glu Asn Trp Trp Trp Val Pro Val
                 300                 305                 310

 gtg gca cca ctt ctg ggt gcc tct cta ggt ggc atc atc tac ctg gtc     1314
 Val Ala Pro Leu Leu Gly Ala Ser Leu Gly Gly Ile Ile Tyr Leu Val
             315                 320                 325

 ttc att ggc tcc acc atc cca cgg gag ccc ctg aaa ttg gag gac tct     1362
 Phe Ile Gly Ser Thr Ile Pro Arg Glu Pro Leu Lys Leu Glu Asp Ser
         330                 335                 340

 gtg gcg tat gaa gac cac ggg ata acc gta ttg ccc aag atg gga tct     1410
 Val Ala Tyr Glu Asp His Gly Ile Thr Val Leu Pro Lys Met Gly Ser
     345                 350                 355

 cat gaa ccc atg atc tct ccc ctc acc ctc atc tcc gtg agc ctt gcc     1458
 His Glu Pro Met Ile Ser Pro Leu Thr Leu Ile Ser Val Ser Leu Ala
 360                 365                 370                 375

 aac aga tct tca gtc cac tct gcc cca ccc tta cat gaa tcc atg gcc     1506
 Asn Arg Ser Ser Val His Ser Ala Pro Pro Leu His Glu Ser Met Ala
                 380                 385                 390

 cta gag cac ttc taa                                                 1521
 Leu Glu His Phe 
             395





      <210> 224
      <211> 2459
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (829)..(2451)

      <400> 224
 gaccgctgac tcggcgcagt ggctctcggt gaaggaagag accatcttcc tgcacgacgg     60

 gctgatccgg gtcaccgacc tggccgagct gcccagcgag atcctcgggg ccccagaggc    120

 cgcggacacc gacctggaga ttttaacctt tgagaccaag aacccgtcgg aattagcaga    180

 acgtttgcgc tctgtttgtg ggaatcagag caatgcctat gcccggctgc tggaataccg    240

 cctgaatgcc ttgcgaggac tgtggaatgc ccagcgccag ctggccttag aagaacagca    300

 tgaaagggaa agttcaggtg atgaggaaac tttggccctg ctcaaacgcc agggcttgtt    360

 gcagcaacct gagcaagcgc ccttcacatc gaggatgggg ctcctgctgg tcttccccct    420

 tattcagtcc cagagtagaa cagacccctc tctctgtaac ataactgctg aggtgctatt    480

 gaactgcctt cgtgactgcc agcctttgag cttgaccaag gagcctgctg actgtctcaa    540

 tggaattgaa actttgctgt gctcttggct agaggagact tctgacacag gccgacacat    600

 cccacataag caaaaagaaa atgctgctgc tgccctggtg gctttggctt gtgccaggga    660

 tcattgaaaa ctttcgtcca cacagtccat ctattacaga aacagacgga tctagggtcc    720

 ctgcctgtag ctgatgtgct atataggctg ttgcttttgg aaggggggcc tggatctccc    780

 tcctgtttgc ttgggggcaa acacatagta tcatggggtt atgaagac atg ttg cct     837
                                                      Met Leu Pro
                                                        1

 gcg ccg gat agc aac act ggc tcc agt tct gaa aat aaa gat gct gac      885
 Ala Pro Asp Ser Asn Thr Gly Ser Ser Ser Glu Asn Lys Asp Ala Asp
       5                  10                  15

 ttg gga cgc tgt ctc acg gca gat ggt ctt tac ctg tat act act aac      933
 Leu Gly Arg Cys Leu Thr Ala Asp Gly Leu Tyr Leu Tyr Thr Thr Asn
  20                  25                  30                  35

 tca gtt gga aga gga gta agc aaa ttg gga tct gga tta cat ggt act      981
 Ser Val Gly Arg Gly Val Ser Lys Leu Gly Ser Gly Leu His Gly Thr
                  40                  45                  50

 ctc aga ggt ttt gtg tac tgc cgg aac gag gag ttg gaa cca gga tgg     1029
 Leu Arg Gly Phe Val Tyr Cys Arg Asn Glu Glu Leu Glu Pro Gly Trp
              55                  60                  65

 gtg gct ttt ggc agc ggc agt ctt ctc cac cgg cct gtc tct ttc gat     1077
 Val Ala Phe Gly Ser Gly Ser Leu Leu His Arg Pro Val Ser Phe Asp
          70                  75                  80

 aat aaa cct cac tcc ctt ttc cag gtc att gac cag aac acc ctt cag     1125
 Asn Lys Pro His Ser Leu Phe Gln Val Ile Asp Gln Asn Thr Leu Gln
      85                  90                  95

 gtg tgc cag gtg gtg cca atg cca gcc aat cac ctc ccc att ggc agc     1173
 Val Cys Gln Val Val Pro Met Pro Ala Asn His Leu Pro Ile Gly Ser
 100                 105                 110                 115

 acc atg agc act gtg cac ctg tct tca gat ggc act tac ttc tat tgg     1221
 Thr Met Ser Thr Val His Leu Ser Ser Asp Gly Thr Tyr Phe Tyr Trp
                 120                 125                 130

 atc tgg tct cct gcc agc ctg aat gag aaa aca ccg aag gga cat tct     1269
 Ile Trp Ser Pro Ala Ser Leu Asn Glu Lys Thr Pro Lys Gly His Ser
             135                 140                 145

 gtc ttc atg gac att ttt gaa ctt gtg gtt gaa aat ggt gta ttt gta     1317
 Val Phe Met Asp Ile Phe Glu Leu Val Val Glu Asn Gly Val Phe Val
         150                 155                 160

 gcc aac cca ctt cag gaa cgt aca att cta atg aga aaa gag ggc gaa     1365
 Ala Asn Pro Leu Gln Glu Arg Thr Ile Leu Met Arg Lys Glu Gly Glu
     165                 170                 175

 tct gcc aaa agc att aat gag atg ctt cta agt aga ctt tct cgg tat     1413
 Ser Ala Lys Ser Ile Asn Glu Met Leu Leu Ser Arg Leu Ser Arg Tyr
 180                 185                 190                 195

 aga gcc tcc ccg tca gca acg ctt gct gcc ctg act ggt tcc acc atc     1461
 Arg Ala Ser Pro Ser Ala Thr Leu Ala Ala Leu Thr Gly Ser Thr Ile
                 200                 205                 210

 tcc aac aca ctg aaa gag gat caa gca gca aat act agc tgt ggg ctg     1509
 Ser Asn Thr Leu Lys Glu Asp Gln Ala Ala Asn Thr Ser Cys Gly Leu
             215                 220                 225

 cct cta aaa atg ctg cgg aag aca ccc ata tat acc tgt ggc acc tac     1557
 Pro Leu Lys Met Leu Arg Lys Thr Pro Ile Tyr Thr Cys Gly Thr Tyr
         230                 235                 240

 ttg gtg atg ctg gtg cct cct cca ggg gga tca ggc agc tct gcc acc     1605
 Leu Val Met Leu Val Pro Pro Pro Gly Gly Ser Gly Ser Ser Ala Thr
     245                 250                 255

 cga tct ctt ttt ggt gga aca agt ggt ttg tca tct tta aaa atc cta     1653
 Arg Ser Leu Phe Gly Gly Thr Ser Gly Leu Ser Ser Leu Lys Ile Leu
 260                 265                 270                 275

 gcc tcc agc ttg gtg tat aat att tcg gat ggt cag ttt aca agt cgt     1701
 Ala Ser Ser Leu Val Tyr Asn Ile Ser Asp Gly Gln Phe Thr Ser Arg
                 280                 285                 290

 gca gat ctc ata gat gct gct gga agc tca ctg ggg cgt ggt gct ctc     1749
 Ala Asp Leu Ile Asp Ala Ala Gly Ser Ser Leu Gly Arg Gly Ala Leu
             295                 300                 305

 gta cca gga ttg gga gcg tgt tat gac aca gtg aac aac atg cta tgg     1797
 Val Pro Gly Leu Gly Ala Cys Tyr Asp Thr Val Asn Asn Met Leu Trp
         310                 315                 320

 aca tgc tca aat gac tat atc gat cag tgg tgt aac cct ggg aat caa     1845
 Thr Cys Ser Asn Asp Tyr Ile Asp Gln Trp Cys Asn Pro Gly Asn Gln
     325                 330                 335

 gcc ttc cat tat gtc tgc cag aga ctt gga gtc agt cac att atc act     1893
 Ala Phe His Tyr Val Cys Gln Arg Leu Gly Val Ser His Ile Ile Thr
 340                 345                 350                 355

 gag ccc aaa gaa gag gct ata acc acg aat gag gtt ata aac caa tta     1941
 Glu Pro Lys Glu Glu Ala Ile Thr Thr Asn Glu Val Ile Asn Gln Leu
                 360                 365                 370

 ttg cac cac gtt ggt gcg atg tgc ata cac caa ctc aat ctt ctt gcc     1989
 Leu His His Val Gly Ala Met Cys Ile His Gln Leu Asn Leu Leu Ala
             375                 380                 385

 acc aac ccc aat ctt cca atc aca agt gtc ttg ggc aag cag cat cca     2037
 Thr Asn Pro Asn Leu Pro Ile Thr Ser Val Leu Gly Lys Gln His Pro
         390                 395                 400

 att gaa gca cat cat ctt agc agt att tgt gac att atg gag aag gcc     2085
 Ile Glu Ala His His Leu Ser Ser Ile Cys Asp Ile Met Glu Lys Ala
     405                 410                 415

 atg gtt aat gga gat acc tgt att ata cgc tgc att ctc gtt gtc ttt     2133
 Met Val Asn Gly Asp Thr Cys Ile Ile Arg Cys Ile Leu Val Val Phe
 420                 425                 430                 435

 cag gtg gta ttt aaa ttt ttc ttc agc cca caa act gaa agg aat cga     2181
 Gln Val Val Phe Lys Phe Phe Phe Ser Pro Gln Thr Glu Arg Asn Arg
                 440                 445                 450

 gac atc att cga cgg tcg gga ttg ctt ctt tgg cag ttg ttg atg gct     2229
 Asp Ile Ile Arg Arg Ser Gly Leu Leu Leu Trp Gln Leu Leu Met Ala
             455                 460                 465

 cca aaa gat caa att tgc cct gaa att cag aag gaa gtc tgc ctt gcc     2277
 Pro Lys Asp Gln Ile Cys Pro Glu Ile Gln Lys Glu Val Cys Leu Ala
         470                 475                 480

 atc agg ctc tgg ttt caa ata tct tgt acc cca ggt gaa act gac atc     2325
 Ile Arg Leu Trp Phe Gln Ile Ser Cys Thr Pro Gly Glu Thr Asp Ile
     485                 490                 495

 act aac tta ctt aaa ctg gtc tta aca gaa ggg aga gag aaa cag tgg     2373
 Thr Asn Leu Leu Lys Leu Val Leu Thr Glu Gly Arg Glu Lys Gln Trp
 500                 505                 510                 515

 act ctc ccc agc tac ggg aat gtg atc cta acc atc ctg tgt gaa cag     2421
 Thr Leu Pro Ser Tyr Gly Asn Val Ile Leu Thr Ile Leu Cys Glu Gln
                 520                 525                 530

 tcc caa aac aac cga ttt ggc agc gga tga gggtgatc                    2459
 Ser Gln Asn Asn Arg Phe Gly Ser Gly 
             535                 540





      <210> 225
      <211> 1694
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (6)..(1694)

      <400> 225
 taaga    atg acc caa aat aaa tta aag ctt tgt tcc aaa gcc aat gtg      47
          Met Thr Gln Asn Lys Leu Lys Leu Cys Ser Lys Ala Asn Val
            1               5                  10

 tat act gaa gtg cct gat gga gga tgg ggc tgg gcg gta gct gtt tca       95
 Tyr Thr Glu Val Pro Asp Gly Gly Trp Gly Trp Ala Val Ala Val Ser
  15                  20                  25                  30

 ttt ttc ttc gtt gaa gtc ttc acc tac ggc atc atc aag aca ttt ggt      143
 Phe Phe Phe Val Glu Val Phe Thr Tyr Gly Ile Ile Lys Thr Phe Gly
                  35                  40                  45

 gtc ttc ttt aat gac tta atg gac agt ttt aat gaa tcc aat agc agg      191
 Val Phe Phe Asn Asp Leu Met Asp Ser Phe Asn Glu Ser Asn Ser Arg
              50                  55                  60

 atc tca tgg ata atc tca atc tgt gtg ttt gtc tta aca ttt tca gct      239
 Ile Ser Trp Ile Ile Ser Ile Cys Val Phe Val Leu Thr Phe Ser Ala
          65                  70                  75

 ccc ctc gcc aca gtc ctg agc aat cgt ttc gga cac cgt ctg gta gtg      287
 Pro Leu Ala Thr Val Leu Ser Asn Arg Phe Gly His Arg Leu Val Val
      80                  85                  90

 atg ttg ggg ggg cta ctt gtc agc acc ggg atg gtg gcc gcc tcc ttc      335
 Met Leu Gly Gly Leu Leu Val Ser Thr Gly Met Val Ala Ala Ser Phe
  95                 100                 105                 110

 tca caa gag gtt tct cat atg tac gtc gcc atc ggc atc atc tct ggt      383
 Ser Gln Glu Val Ser His Met Tyr Val Ala Ile Gly Ile Ile Ser Gly
                 115                 120                 125

 ctg gga tac tgc ttt agt ttt ctc cca act gta acc atc cta tca caa      431
 Leu Gly Tyr Cys Phe Ser Phe Leu Pro Thr Val Thr Ile Leu Ser Gln
             130                 135                 140

 tat ttt ggc aaa aga cgt tcc ata gtc act gca gtt gct tcc aca gga      479
 Tyr Phe Gly Lys Arg Arg Ser Ile Val Thr Ala Val Ala Ser Thr Gly
         145                 150                 155

 gaa tgt ttc gct gtg ttt gct ttc gca cca gca atc atg gct ctg aag      527
 Glu Cys Phe Ala Val Phe Ala Phe Ala Pro Ala Ile Met Ala Leu Lys
     160                 165                 170

 gag cgc att ggc tgg aga tac agc ctc ctc ttc gtg ggc cta cta cag      575
 Glu Arg Ile Gly Trp Arg Tyr Ser Leu Leu Phe Val Gly Leu Leu Gln
 175                 180                 185                 190

 tta aac att gtc atc ttc gga gca ctg ctc aga ccc atc att atc aga      623
 Leu Asn Ile Val Ile Phe Gly Ala Leu Leu Arg Pro Ile Ile Ile Arg
                 195                 200                 205

 gga cca gcg tca ccg aaa ata gtc atc cag gaa aat cgg aaa gaa gcg      671
 Gly Pro Ala Ser Pro Lys Ile Val Ile Gln Glu Asn Arg Lys Glu Ala
             210                 215                 220

 cag tat atg ctt gaa aat gag aaa aca cga acc tca ata gac tcc att      719
 Gln Tyr Met Leu Glu Asn Glu Lys Thr Arg Thr Ser Ile Asp Ser Ile
         225                 230                 235

 gac tca gga gta gaa cta act acc tca cct aaa aat gtg cct act cac      767
 Asp Ser Gly Val Glu Leu Thr Thr Ser Pro Lys Asn Val Pro Thr His
     240                 245                 250

 act aac ctg gaa ctg gag ccg aag gcc gac atg cag cag gtc ctg gtg      815
 Thr Asn Leu Glu Leu Glu Pro Lys Ala Asp Met Gln Gln Val Leu Val
 255                 260                 265                 270

 aag acc agc ccc agg cca agc gaa aag aaa gcc ccg cta tta gac ttc      863
 Lys Thr Ser Pro Arg Pro Ser Glu Lys Lys Ala Pro Leu Leu Asp Phe
                 275                 280                 285

 tcc att ttg aaa gag aaa agt ttt att tgt tat gca tta ttt ggt ctc      911
 Ser Ile Leu Lys Glu Lys Ser Phe Ile Cys Tyr Ala Leu Phe Gly Leu
             290                 295                 300

 ttt gca aca ctg gga ttc ttt gca cct tcc ttg tac atc att cct ctg      959
 Phe Ala Thr Leu Gly Phe Phe Ala Pro Ser Leu Tyr Ile Ile Pro Leu
         305                 310                 315

 ggc att agt ctg ggc att gac cag gac cgc gct gct ttt tta tta tct     1007
 Gly Ile Ser Leu Gly Ile Asp Gln Asp Arg Ala Ala Phe Leu Leu Ser
     320                 325                 330

 acg atg gcc att gca gaa gtt ttc gga agg atc gga gct ggt ttt gtc     1055
 Thr Met Ala Ile Ala Glu Val Phe Gly Arg Ile Gly Ala Gly Phe Val
 335                 340                 345                 350

 ctc aac agg gag ccc att cgt aag att tac att gag ctc atc tgc gtc     1103
 Leu Asn Arg Glu Pro Ile Arg Lys Ile Tyr Ile Glu Leu Ile Cys Val
                 355                 360                 365

 atc tta ttg act gtg tct ctg ttt gcc ttt act ttt gct act gaa ttc     1151
 Ile Leu Leu Thr Val Ser Leu Phe Ala Phe Thr Phe Ala Thr Glu Phe
             370                 375                 380

 tgg ggt cta atg tca tgc agc ata ttt ttt ggg ttt atg gtt gga aca     1199
 Trp Gly Leu Met Ser Cys Ser Ile Phe Phe Gly Phe Met Val Gly Thr
         385                 390                 395

 ata gga ggg act cac att cca ctg ctt gct gag gat gat gtc gtg ggc     1247
 Ile Gly Gly Thr His Ile Pro Leu Leu Ala Glu Asp Asp Val Val Gly
     400                 405                 410

 att gag aag atg tct tct gca gct ggg gtc tac atc ttc att cag agc     1295
 Ile Glu Lys Met Ser Ser Ala Ala Gly Val Tyr Ile Phe Ile Gln Ser
 415                 420                 425                 430

 ata gca gga ctg gct gga ccg ccc ctt gca ggt ttg ttg gtg gac caa     1343
 Ile Ala Gly Leu Ala Gly Pro Pro Leu Ala Gly Leu Leu Val Asp Gln
                 435                 440                 445

 agt aag atc tac agc agg gcc ttc tac tcc tgc gca gct ggc atg gcc     1391
 Ser Lys Ile Tyr Ser Arg Ala Phe Tyr Ser Cys Ala Ala Gly Met Ala
             450                 455                 460

 ctg gct gct gtg tgc ctc gcc ctg gtg aga ccg tgt aag atg gga ctg     1439
 Leu Ala Ala Val Cys Leu Ala Leu Val Arg Pro Cys Lys Met Gly Leu
         465                 470                 475

 tgc cag cat cat cac tca ggt gaa aca aag gta gtg agc cat cgt ggg     1487
 Cys Gln His His His Ser Gly Glu Thr Lys Val Val Ser His Arg Gly
     480                 485                 490

 aag act tta cag gac ata cct gaa gac ttt ctg gaa atg gat ctt gca     1535
 Lys Thr Leu Gln Asp Ile Pro Glu Asp Phe Leu Glu Met Asp Leu Ala
 495                 500                 505                 510

 aaa aat gag cac aga gtt cac gtg caa atg gag ccg gtg cag aac aag     1583
 Lys Asn Glu His Arg Val His Val Gln Met Glu Pro Val Gln Asn Lys
                 515                 520                 525

 aaa agt ggc aag aga act tac aac ttc cct ttc cat gta aca act cac     1631
 Lys Ser Gly Lys Arg Thr Tyr Asn Phe Pro Phe His Val Thr Thr His
             530                 535                 540

 cca aat caa aac tac ttc aat gac tat cca ttt cct aca tgg aaa att     1679
 Pro Asn Gln Asn Tyr Phe Asn Asp Tyr Pro Phe Pro Thr Trp Lys Ile
         545                 550                 555

 aga cgg gaa acc tga                                                 1694
 Arg Arg Glu Thr 
     560





      <210> 226
      <211> 1247
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (44)..(511)

      <400> 226
 gccgcctcgg gccgcagagc ttgccccctc cccacccgca aac  atg ttc gag tcc      55
                                                  Met Phe Glu Ser
                                                    1

 aag aac ggc ccc gag tat gct tcg ttt ttc ccc gtc atg ggc gcc tcg      103
 Lys Asn Gly Pro Glu Tyr Ala Ser Phe Phe Pro Val Met Gly Ala Ser
   5                  10                  15                  20

 gcc gcc atg gtc ttc agc gcc ctg ggc cct gcc tat ggc tca acc aag      151
 Ala Ala Met Val Phe Ser Ala Leu Gly Pro Ala Tyr Gly Ser Thr Lys
                  25                  30                  35

 agc ggt acc ggc att tcg gcc atg tct gtc att cgg ccg gag cag atc      199
 Ser Gly Thr Gly Ile Ser Ala Met Ser Val Ile Arg Pro Glu Gln Ile
              40                  45                  50

 atg aag tcc atc atc cca gtg gtc atg gct ggc atc atc gcc atc tac      247
 Met Lys Ser Ile Ile Pro Val Val Met Ala Gly Ile Ile Ala Ile Tyr
          55                  60                  65

 ggc ctg gtg gtg gca gtc ctc atc gcc aac tcc ctg aat gac gac atc      295
 Gly Leu Val Val Ala Val Leu Ile Ala Asn Ser Leu Asn Asp Asp Ile
      70                  75                  80

 agc ctc tac aag agc ttc ctc cag ctg ggc gcc ggc ctg agc gtg ggc      343
 Ser Leu Tyr Lys Ser Phe Leu Gln Leu Gly Ala Gly Leu Ser Val Gly
  85                  90                  95                 100

 ctg agc ggc ctg gca gcc ggc ttt gcc atc ggc atc gtg ggg gac gct      391
 Leu Ser Gly Leu Ala Ala Gly Phe Ala Ile Gly Ile Val Gly Asp Ala
                 105                 110                 115

 ggc gtg cgg ggc acc gcc cag cag ccc cga cta ttc gtg ggc atg atc      439
 Gly Val Arg Gly Thr Ala Gln Gln Pro Arg Leu Phe Val Gly Met Ile
             120                 125                 130

 ctg att ctc atc ttc gcc gag gtg ctc ggc ctc tac ggt ctc atc gtc      487
 Leu Ile Leu Ile Phe Ala Glu Val Leu Gly Leu Tyr Gly Leu Ile Val
         135                 140                 145

 gcc ctc atc ctc tcc aca aag tag accctctccg agcccaccag ccacagaata     541
 Ala Leu Ile Leu Ser Thr Lys 
     150                 155

 ttatgtaaag accacccctc ctcattccag aacgaacagc ctgacacata cgcacggggc    601

 cgccgccccc agtagttggt cttgtacatg cgcagtgtcc tagtgcccat cgtctgtttc    661

 cccggccttg cccccgcccg ccccgtgccg tggacatctg ggcccactca tcgcccctcc    721

 aggcccccgg cgccccaccc cctagagtgc tctgtgtatg cggatgattt agaattgtca    781

 tttctcttta ctggatgttt atttataaag atctggcctg ttcctgcgtc tgcggagcgg    841

 cccttgtctc ccagctatct ataaccttag ctagagtgtc gccttgtggg ttcctgttgc    901

 tgagacttcc tggatggagc cgccctcacc gccgggcccg tggccctgcg cggagctgtg    961

 tccaataaag ttcttggatg tgaaaaaaaa aaaaaaaaag ggggttgtgc ccttaaaaga   1021

 aacaacggtc ccctggggct gtctccaaaa aaagtttttt attacattgc caaagaaacg   1081

 gatgactggg ccggcctgat gattacaggg aaactgaaaa ttccgagcag accccccctt   1141

 attgcggtgg ggccatagcc tctgccctga tcatcaaagc cctcaaggaa ccaccaagag   1201

 acagaaagaa acagaaaaac attaaacaca gtgggaatat cacttg                  1247




      <210> 227
      <211> 2032
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (419)..(1402)

      <400> 227
 ggcaggacct gctcagccaa tcagcttttc ctttctcaga actgcccgtg gaaacctggc     60

 tgggcttctg gcttcagagc tgggaattgt gggaggaggg cccagatccc actggagata    120

 ccgaaggaga tactctttag tattgggatc ccagaaacca gtcctatatc tggccagagg    180

 gacactgggt tgtggcatct ctctagctgc tacccagaag gaacagggcc ccctggggcc    240

 tataggcctt gcccctgacc ctgggaacac ccagctcagg cctgccccag tggccacaag    300

 tcagggaggc cgcaaatttt taactagaaa cattgatcat taataggggg ttagaaagag    360

 ttcaaactaa gtctcactct gggacataga ccaattgtgc ttcaggcctc ctgcagag      418                                                                 
 atg ctg ggt ccc caa gtc tgg tct tct gtg agg cag ggg cta agc agg      466
 Met Leu Gly Pro Gln Val Trp Ser Ser Val Arg Gln Gly Leu Ser Arg
   1               5                  10                  15

 agc ttg tcc agg aat gtg ggg gtc tgg gcc tca ggg gag ggg aag aag      514
 Ser Leu Ser Arg Asn Val Gly Val Trp Ala Ser Gly Glu Gly Lys Lys
              20                  25                  30

 gtg gac att gcg ggt atc tac ccc cct gtg acc acc ccc ttc act gcc      562
 Val Asp Ile Ala Gly Ile Tyr Pro Pro Val Thr Thr Pro Phe Thr Ala
          35                  40                  45

 act gca gag gtg gac tat ggg aaa ctg gag gag aat ctg cac aaa ctg      610
 Thr Ala Glu Val Asp Tyr Gly Lys Leu Glu Glu Asn Leu His Lys Leu
      50                  55                  60

 ggc acc ttc ccc ttc cga ggc ttc gtg gtc cag ggc tcc aat ggc gag      658
 Gly Thr Phe Pro Phe Arg Gly Phe Val Val Gln Gly Ser Asn Gly Glu
  65                  70                  75                  80

 ttt cct ttc ctg acc agc agt gag cgc ctc gag gtg gtg agc cgt gtg      706
 Phe Pro Phe Leu Thr Ser Ser Glu Arg Leu Glu Val Val Ser Arg Val
                  85                  90                  95

 cgc cag gcc atg ccc atg aac agg ctc ctg cta gct ggc tcc gga tgc      754
 Arg Gln Ala Met Pro Met Asn Arg Leu Leu Leu Ala Gly Ser Gly Cys
             100                 105                 110

 gag tcc act caa gcc aca gtg gag atg acc gtc agc atg gcc cag gtc      802
 Glu Ser Thr Gln Ala Thr Val Glu Met Thr Val Ser Met Ala Gln Val
         115                 120                 125

 ggg gct gac gcg gcc atg gtg gtg acc cct tgc tac tat cgt ggc cgc      850
 Gly Ala Asp Ala Ala Met Val Val Thr Pro Cys Tyr Tyr Arg Gly Arg
     130                 135                 140

 atg agc agt gcg gcc ctc att cac cac tac acc aag gtt gct gat ctc      898
 Met Ser Ser Ala Ala Leu Ile His His Tyr Thr Lys Val Ala Asp Leu
 145                 150                 155                 160

 tct cca atc cct gtg gtg ctg tac agt gtc cca gcc aac aca ggg ctg      946
 Ser Pro Ile Pro Val Val Leu Tyr Ser Val Pro Ala Asn Thr Gly Leu
                 165                 170                 175

 gac ctg cct gtg gat gca gtg gtc acg ctt tcc cag cac ccg aat att      994
 Asp Leu Pro Val Asp Ala Val Val Thr Leu Ser Gln His Pro Asn Ile
             180                 185                 190

 gtg ggc atg aag gac agc ggt ggt gat gtg acc agg att ggg ctg att     1042
 Val Gly Met Lys Asp Ser Gly Gly Asp Val Thr Arg Ile Gly Leu Ile
         195                 200                 205

 gtt cac aag acc agg aag cag gat ttt cag gtg ttg gct gga tcg gct     1090
 Val His Lys Thr Arg Lys Gln Asp Phe Gln Val Leu Ala Gly Ser Ala
     210                 215                 220

 ggc ttt ctg atg gcc agc tat gcc ttg gga gct gtg ggg ggc gtc tgc     1138
 Gly Phe Leu Met Ala Ser Tyr Ala Leu Gly Ala Val Gly Gly Val Cys
 225                 230                 235                 240

 gcc ctg gcc aat gtc ctg ggg gct cag gtg tgc cag ctg gag cga ctg     1186
 Ala Leu Ala Asn Val Leu Gly Ala Gln Val Cys Gln Leu Glu Arg Leu
                 245                 250                 255

 tgc tgc acg ggg caa tgg gaa gat gcc cag aaa ctg cag cac cgc ctc     1234
 Cys Cys Thr Gly Gln Trp Glu Asp Ala Gln Lys Leu Gln His Arg Leu
             260                 265                 270

 att gag cca aac gct gcg gtg acc cgg cgc ttt ggg atc cca ggg ctg     1282
 Ile Glu Pro Asn Ala Ala Val Thr Arg Arg Phe Gly Ile Pro Gly Leu
         275                 280                 285

 aag aaa atc atg gac tgg ttt ggc tac tat gga ggc ccc tgc cgc gcc     1330
 Lys Lys Ile Met Asp Trp Phe Gly Tyr Tyr Gly Gly Pro Cys Arg Ala
     290                 295                 300

 ccc ttg cag gag ctg agc ccc gct gag gag gag gca ctg cgc atg gat     1378
 Pro Leu Gln Glu Leu Ser Pro Ala Glu Glu Glu Ala Leu Arg Met Asp
 305                 310                 315                 320

 ttc acc agc aac ggc tgg ctc tga gggcaggcag ggtccatggc tggcctgagc    1432
 Phe Thr Ser Asn Gly Trp Leu 
                 325

 ccatctcagc ctcctgcctt gcacttgcag cctgaagcgg agagcacagg gggatgaggg   1492

 tggcaggcag cggggagccg atagaggctc ctttgcctgc tgtggtcctc caggcagcct   1552

 ttcacaggca cgcccatgca tatctcctat tctaacggcc cctgacctct cccttttgga   1612

 tcctaaactg tgtctctggt ctgaagactg ggaaggagca atttctcaat ttatctttct   1672

 actgtggatg ctttcctacg ccctgaggca catgaagtca gaaaggaagg gcagaggggc   1732

 aagtaggcac agtaagggaa ttttcttttc tttttttttt ttttgaaaaa aaattttatt   1792

 tttgcccccc aggggggggg gaaagggaca taaccccccc ccggggttaa aagaattttc   1852

 ctggctaaac cccccaaata cggggaaata aagggccctg cccccacccc aaaataattt   1912

 ttgtttttta aaaaaaaagg gggtttcccc gggggggccc ggggggtttt aaacccccga   1972

 ccccagggga accaattggc ttggccctcc aaaagggggg gaataaccgg gggaaccccc   2032




      <210> 228
      <211> 3378
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (166)..(3378)

      <400> 228
 atgtcactga gcagaggcgt gagactgccg gccagccctg ctgtgtacac tgatagaatt     60

 agtgagcgag cgtcccactc tgatggaatc cagatggaac tcgtcactgt cactgcggtg    120

 gagacgtccc tcgggctcat acctagtgcc tgcggcagga cagcc    atg gcc gcc     174
                                                      Met Ala Ala
                                                        1

 aac tcc acc agc gac ctc cac act ccc ggg acg cag ctg agc gtg gct      222
 Asn Ser Thr Ser Asp Leu His Thr Pro Gly Thr Gln Leu Ser Val Ala
       5                  10                  15

 gac atc atc gtc atc act gtg tat ttt gct ctg aac gtg gcc gtg ggc      270
 Asp Ile Ile Val Ile Thr Val Tyr Phe Ala Leu Asn Val Ala Val Gly
  20                  25                  30                  35

 ata tgg tcc tct tgt cgg gcc agt agg aac acg gtg aat ggc tac ttc      318
 Ile Trp Ser Ser Cys Arg Ala Ser Arg Asn Thr Val Asn Gly Tyr Phe
                  40                  45                  50

 ctg gca ggc cgg gac atg acg tgg tgg ccg att gga gcc tcc ctc ttc      366
 Leu Ala Gly Arg Asp Met Thr Trp Trp Pro Ile Gly Ala Ser Leu Phe
              55                  60                  65

 gcc agc agc gag ggc tct ggc ctc ttc att gga ctg gcg ggc tca ggc      414
 Ala Ser Ser Glu Gly Ser Gly Leu Phe Ile Gly Leu Ala Gly Ser Gly
          70                  75                  80

 gcg gca gga ggt ctg gcc gtg gca ggc ttc gag tgg aat gcc acg tac      462
 Ala Ala Gly Gly Leu Ala Val Ala Gly Phe Glu Trp Asn Ala Thr Tyr
      85                  90                  95

 gtg ctg ctg gca ctg gca tgg gtg ttc gtg ccc atc tac atc tcc tca      510
 Val Leu Leu Ala Leu Ala Trp Val Phe Val Pro Ile Tyr Ile Ser Ser
 100                 105                 110                 115

 gag atc gtc acc tta cct gag tac att cag aag cgc tac ggg ggc cag      558
 Glu Ile Val Thr Leu Pro Glu Tyr Ile Gln Lys Arg Tyr Gly Gly Gln
                 120                 125                 130

 cgg atc cgc atg tac ctg tct gtc ctg tcc ctg cta ctg tct gtc ttc      606
 Arg Ile Arg Met Tyr Leu Ser Val Leu Ser Leu Leu Leu Ser Val Phe
             135                 140                 145

 acc aag ata tcg ctg gac ctg tac gcg ggg gct ctg ttt gtg cac atc      654
 Thr Lys Ile Ser Leu Asp Leu Tyr Ala Gly Ala Leu Phe Val His Ile
         150                 155                 160

 tgc ctg ggc tgg aac ttc tac ctc tcc acc atc ctc acg ctc ggc atc      702
 Cys Leu Gly Trp Asn Phe Tyr Leu Ser Thr Ile Leu Thr Leu Gly Ile
     165                 170                 175

 aca gcc ctg tac acc atc gca ggg ggc ctg gct gct gta atc tac acg      750
 Thr Ala Leu Tyr Thr Ile Ala Gly Gly Leu Ala Ala Val Ile Tyr Thr
 180                 185                 190                 195

 gac gcc ctg cag acg ctc atc atg gtg gtg ggg gct gtc atc ctg aca      798
 Asp Ala Leu Gln Thr Leu Ile Met Val Val Gly Ala Val Ile Leu Thr
                 200                 205                 210

 atc aaa ggg act gcc ctg gct ggt aga ggc tac cca ccc tgc tgc ccc      846
 Ile Lys Gly Thr Ala Leu Ala Gly Arg Gly Tyr Pro Pro Cys Cys Pro
             215                 220                 225

 gct gtt acc agc tct ggc cct ggc aag gag ctg act cag gaa ctc agg      894
 Ala Val Thr Ser Ser Gly Pro Gly Lys Glu Leu Thr Gln Glu Leu Arg
         230                 235                 240

 gcc agc cac acc cgc att ggc tca gcg ctt gat gct ttt gac cag atc      942
 Ala Ser His Thr Arg Ile Gly Ser Ala Leu Asp Ala Phe Asp Gln Ile
     245                 250                 255

 ggt ggt tac ggg cag ctg gag gca gcc tac gcc cag gcc att ccc tcc      990
 Gly Gly Tyr Gly Gln Leu Glu Ala Ala Tyr Ala Gln Ala Ile Pro Ser
 260                 265                 270                 275

 agg acc att gcc aac acc acc tgc cac ctg cca cgt aca gac gcc atg     1038
 Arg Thr Ile Ala Asn Thr Thr Cys His Leu Pro Arg Thr Asp Ala Met
                 280                 285                 290

 cac atg ttt cga gac ccc cac aca ggg gac ctg ccg tgg acc ggg atg     1086
 His Met Phe Arg Asp Pro His Thr Gly Asp Leu Pro Trp Thr Gly Met
             295                 300                 305

 acc ttt ggc ctg acc atc atg gcc acc tgg tac tgg tgc acc gac cag     1134
 Thr Phe Gly Leu Thr Ile Met Ala Thr Trp Tyr Trp Cys Thr Asp Gln
         310                 315                 320

 gtg ctt cga ctg aga cag ttt gga gta tgg gat tcc gaa ggg act cgg     1182
 Val Leu Arg Leu Arg Gln Phe Gly Val Trp Asp Ser Glu Gly Thr Arg
     325                 330                 335

 atg ctc ctc ggt ggc cct gcc atc ggt cat ggg gcg ggc att ttg ggc     1230
 Met Leu Leu Gly Gly Pro Ala Ile Gly His Gly Ala Gly Ile Leu Gly
 340                 345                 350                 355

 cag tct tgg gct gcc ggg atc cgg aag cag gcg ggg tac ctg acc tcc     1278
 Gln Ser Trp Ala Ala Gly Ile Arg Lys Gln Ala Gly Tyr Leu Thr Ser
                 360                 365                 370

 ctt ggc ctg cca gtg gtg ggg gcc agc cat ggc tgg gcc agc gtt tct     1326
 Leu Gly Leu Pro Val Val Gly Ala Ser His Gly Trp Ala Ser Val Ser
             375                 380                 385

 ggt aga gct ctg gac gct gtc agc agc aga gcg gtc atc gtg cag cga     1374
 Gly Arg Ala Leu Asp Ala Val Ser Ser Arg Ala Val Ile Val Gln Arg
         390                 395                 400

 tca ctg tca gcc cgg gac ctg aac cat gcc aag gcg ggc tcc atc ctg     1422
 Ser Leu Ser Ala Arg Asp Leu Asn His Ala Lys Ala Gly Ser Ile Leu
     405                 410                 415

 gcc agc tac ctc aag atg ctc ccc atg ggc ctg atc atc atg ccg ggc     1470
 Ala Ser Tyr Leu Lys Met Leu Pro Met Gly Leu Ile Ile Met Pro Gly
 420                 425                 430                 435

 atg atc agc cgc gca ttg ttc cca ggg atg ccc ttg agg ctc aca ctg     1518
 Met Ile Ser Arg Ala Leu Phe Pro Gly Met Pro Leu Arg Leu Thr Leu
                 440                 445                 450

 tgt gac atg agg tac agc tcc tgg aac tgc cgg tca aac atc tcc acc     1566
 Cys Asp Met Arg Tyr Ser Ser Trp Asn Cys Arg Ser Asn Ile Ser Thr
             455                 460                 465

 acc tgg cca gac agc aca gag atc aca ttc cgg tcc gtc cgc gcg gcc     1614
 Thr Trp Pro Asp Ser Thr Glu Ile Thr Phe Arg Ser Val Arg Ala Ala
         470                 475                 480

 gac cac gtg aag ctg caa cag agg gag ggg gcg ctg gtc agg cac atg     1662
 Asp His Val Lys Leu Gln Gln Arg Glu Gly Ala Leu Val Arg His Met
     485                 490                 495

 acc ctg ctt cct ccg ccc agc ccc cgt gca ccc ata gcc gct ggg cct     1710
 Thr Leu Leu Pro Pro Pro Ser Pro Arg Ala Pro Ile Ala Ala Gly Pro
 500                 505                 510                 515

 cag act gtg gcc aca ggg ccc tgg gat caa gaa gtg aat ggg ggc aga     1758
 Gln Thr Val Ala Thr Gly Pro Trp Asp Gln Glu Val Asn Gly Gly Arg
                 520                 525                 530

 gag cag acc cct gtg gct ggg gtg gcc cca ggc aag caa cca cag agg     1806
 Glu Gln Thr Pro Val Ala Gly Val Ala Pro Gly Lys Gln Pro Gln Arg
             535                 540                 545

 cag gca ggt gtg ggc cgt ggg ctg cag gtt tgc aca cag cca gct cag     1854
 Gln Ala Gly Val Gly Arg Gly Leu Gln Val Cys Thr Gln Pro Ala Gln
         550                 555                 560

 cag gaa gct ggc cac ggc cca gga caa tta gcg ctc gtg act ttg tac     1902
 Gln Glu Ala Gly His Gly Pro Gly Gln Leu Ala Leu Val Thr Leu Tyr
     565                 570                 575

 cca aca tgg agc acg ctc ggg gtt gag aag tcg gac aaa gat cct gga     1950
 Pro Thr Trp Ser Thr Leu Gly Val Glu Lys Ser Asp Lys Asp Pro Gly
 580                 585                 590                 595

 ggt ggg aat tca agc agt ggc tat gtg act gct tgg cag gag gct cta     1998
 Gly Gly Asn Ser Ser Ser Gly Tyr Val Thr Ala Trp Gln Glu Ala Leu
                 600                 605                 610

 gga tta ctg gac tct gag tgc ctg gca cag gac tcc gtc cag agc agg     2046
 Gly Leu Leu Asp Ser Glu Cys Leu Ala Gln Asp Ser Val Gln Ser Arg
             615                 620                 625

 cag gta ctc gaa gtg ttt gtt gac aga ctg aat gac ccc tgc cct cca     2094
 Gln Val Leu Glu Val Phe Val Asp Arg Leu Asn Asp Pro Cys Pro Pro
         630                 635                 640

 gcc acc cag gca agt gag gag cct gct cac ctt gag gtg ccc cag gtg     2142
 Ala Thr Gln Ala Ser Glu Glu Pro Ala His Leu Glu Val Pro Gln Val
     645                 650                 655

 cat gca ggc ccg ctc aca cat gtg cag gaa gta ctt gac gtt act ctc     2190
 His Ala Gly Pro Leu Thr His Val Gln Glu Val Leu Asp Val Thr Leu
 660                 665                 670                 675

 atc cac gat gat gta cac ggc cac ttt cct ctt gaa gcc ggc gtc cag     2238
 Ile His Asp Asp Val His Gly His Phe Pro Leu Glu Ala Gly Val Gln
                 680                 685                 690

 cag gtc ctt gaa gat gtc cac ggt ctg cct gtt gtg ctg acg aca ggt     2286
 Gln Val Leu Glu Asp Val His Gly Leu Pro Val Val Leu Thr Thr Gly
             695                 700                 705

 aag gat gcg ctt gag ctc cag ctc cga gag gaa gtc tcg gat gtt ctc     2334
 Lys Asp Ala Leu Glu Leu Gln Leu Arg Glu Glu Val Ser Asp Val Leu
         710                 715                 720

 ccg ctt gag cac ctc gta gaa ggc gtc ccg gcc gcg ggc cac cag ggc     2382
 Pro Leu Glu His Leu Val Glu Gly Val Pro Ala Ala Gly His Gln Gly
     725                 730                 735

 ctc cag cgc cag ccg ctg ctc ctc gct gta gaa gaa ctc agg ctt gga     2430
 Leu Gln Arg Gln Pro Leu Leu Leu Ala Val Glu Glu Leu Arg Leu Gly
 740                 745                 750                 755

 ctc gct gga gcg cca gtt cac atg gtt gtc gtc cag aca ctg cac ctg     2478
 Leu Ala Gly Ala Pro Val His Met Val Val Val Gln Thr Leu His Leu
                 760                 765                 770

 aga gaa ggc cat ggc gcc gcc tgc ccg ggc act gct gcc ggg ggt gct     2526
 Arg Glu Gly His Gly Ala Ala Cys Pro Gly Thr Ala Ala Gly Gly Ala
             775                 780                 785

 cat gtc tat gag gag aga cac caa gtg tcc gtc tct cga aca gat gat     2574
 His Val Tyr Glu Glu Arg His Gln Val Ser Val Ser Arg Thr Asp Asp
         790                 795                 800

 gtg ggc tgc gtg gtg ccg tcc gag tgc ctg cgg gcc tgc ggg gcc gag     2622
 Val Gly Cys Val Val Pro Ser Glu Cys Leu Arg Ala Cys Gly Ala Glu
     805                 810                 815

 gtc ggc tgc tcc aac atc gcc tac ccc aag ctg gtc atg gaa ctg atg     2670
 Val Gly Cys Ser Asn Ile Ala Tyr Pro Lys Leu Val Met Glu Leu Met
 820                 825                 830                 835

 ccc atc ggt ctg cgg ggg ctg atg atc gca gtg atg ctg gcg gcg ctc     2718
 Pro Ile Gly Leu Arg Gly Leu Met Ile Ala Val Met Leu Ala Ala Leu
                 840                 845                 850

 atg tcg tcg ctg acc tcc atc ttc aac agc agc agc acc ctc ttc act     2766
 Met Ser Ser Leu Thr Ser Ile Phe Asn Ser Ser Ser Thr Leu Phe Thr
             855                 860                 865

 atg gac atc tgg agg cgg ctg cgt ccc cgc tcc ggc gag cgg gag ctc     2814
 Met Asp Ile Trp Arg Arg Leu Arg Pro Arg Ser Gly Glu Arg Glu Leu
         870                 875                 880

 ctg ctg gtg gga cgg ctg gtc ata gtg gca ctc atc ggc gtg agt gtg     2862
 Leu Leu Val Gly Arg Leu Val Ile Val Ala Leu Ile Gly Val Ser Val
     885                 890                 895

 gcc tgg atc ccc gtc ctg cag gac tcc aac agc ggg caa ctc ttc atc     2910
 Ala Trp Ile Pro Val Leu Gln Asp Ser Asn Ser Gly Gln Leu Phe Ile
 900                 905                 910                 915

 tac atg cag tca gtg acc agc tcc ctg gcc cca cca gtg act gca gtc     2958
 Tyr Met Gln Ser Val Thr Ser Ser Leu Ala Pro Pro Val Thr Ala Val
                 920                 925                 930

 ttt gtc ctg ggc gtc ttc tgg cga cgt gcc aac gag cag ggg gcc ttc     3006
 Phe Val Leu Gly Val Phe Trp Arg Arg Ala Asn Glu Gln Gly Ala Phe
             935                 940                 945

 tgg ggc ctg ata gca ggg ctg gtg gtg ggg gcc acg agg ctg gtc ctg     3054
 Trp Gly Leu Ile Ala Gly Leu Val Val Gly Ala Thr Arg Leu Val Leu
         950                 955                 960

 gaa ttc ctg aac cca gcc cca ccg tgc gga gag cca gac acg cgg cca     3102
 Glu Phe Leu Asn Pro Ala Pro Pro Cys Gly Glu Pro Asp Thr Arg Pro
     965                 970                 975

 gcc gtc ctg ggg agc atc cac tac ctg cac ttc gct gtc gcc ctc ttt     3150
 Ala Val Leu Gly Ser Ile His Tyr Leu His Phe Ala Val Ala Leu Phe
 980                 985                 990                 995

 gca ctc agt ggt gct gtt gtg gtg gct gga agc ctg ctg acc cca ccc     3198
 Ala Leu Ser Gly Ala Val Val Val Ala Gly Ser Leu Leu Thr Pro Pro
                1000                1005                1010

 cca cag agt gtc cag att gag aac ctt acc tgg tgg acc ctg gct cag     3246
 Pro Gln Ser Val Gln Ile Glu Asn Leu Thr Trp Trp Thr Leu Ala Gln
            1015                1020                1025

 gat gtg ccc ttg gga act aaa gca ggt gat ggc caa aca ccc cag aaa     3294
 Asp Val Pro Leu Gly Thr Lys Ala Gly Asp Gly Gln Thr Pro Gln Lys
        1030                1035                1040

 cac gcc ttc tgg gcc cgt gtc tgt ggc ttc aat gcc atc ctc ctc atg     3342
 His Ala Phe Trp Ala Arg Val Cys Gly Phe Asn Ala Ile Leu Leu Met
    1045                1050                1055

 tgt gtc aac ata ttc ttt tat gcc tac ttc gcc tga                     3378
 Cys Val Asn Ile Phe Phe Tyr Ala Tyr Phe Ala 
1060                1065                1070





      <210> 229
      <211> 1979
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (360)..(1979)

      <400> 229
 gggcccggca gaaggccgag taggagggac cacgcgccgg gggccgcgat ctctggcagg     60

 gggcggtgtg ccagcggagc accatgcaca taggcgccca gcgccccgac tacccctccc    120

 gaggaaaaga ggccggggcc gcgctggggc ggcggagagc atgagggagg ccggggggcg    180

 gctcggcttg gagcgctgct agggagcggt gcgcgccgca cacccgcctg ggcgcggcgg    240

 agggcgggga gccgggcagg tcgcgcctgc gggcggcagc cgaccgccgg gagctgttct    300

 gatttccgac gcgcacgcta ggggcccgga gcagcccccg gccccggcgc gccgccgac     359                                                                 
 atg ggc aac gca ggg agc atg gat tcg cag cag acc gat ttc agg gcg      407
 Met Gly Asn Ala Gly Ser Met Asp Ser Gln Gln Thr Asp Phe Arg Ala
   1               5                  10                  15

 cac aac gtg cct ttg aag ctg ccg atg cca gag cca ggt gaa ctg gag      455
 His Asn Val Pro Leu Lys Leu Pro Met Pro Glu Pro Gly Glu Leu Glu
              20                  25                  30

 gag cga ttt gcc atc gtg ctg aac gct atg aac cta cct cct gac aaa      503
 Glu Arg Phe Ala Ile Val Leu Asn Ala Met Asn Leu Pro Pro Asp Lys
          35                  40                  45

 gcc agg tta ctg cgg cag tat gat aat gag aaa aaa tgg gaa ctg att      551
 Ala Arg Leu Leu Arg Gln Tyr Asp Asn Glu Lys Lys Trp Glu Leu Ile
      50                  55                  60

 tgt gat cag gaa cga ttc cag gtg aag aat cct ccc cat aca tac att      599
 Cys Asp Gln Glu Arg Phe Gln Val Lys Asn Pro Pro His Thr Tyr Ile
  65                  70                  75                  80

 caa aag ctc aaa ggc tat ctg gat cca gct gta acc agg aag aaa ttc      647
 Gln Lys Leu Lys Gly Tyr Leu Asp Pro Ala Val Thr Arg Lys Lys Phe
                  85                  90                  95

 aga cgg cgt gtt caa gaa tct aca caa gtg cta aga gaa ctg gaa att      695
 Arg Arg Arg Val Gln Glu Ser Thr Gln Val Leu Arg Glu Leu Glu Ile
             100                 105                 110

 tct ttg aga act aac cac att gga tgg gtc aga gaa ttt ctg aat gaa      743
 Ser Leu Arg Thr Asn His Ile Gly Trp Val Arg Glu Phe Leu Asn Glu
         115                 120                 125

 gaa aac aaa ggt ctt gat gtt cta gtg gaa tat ctc tca ttt gca cag      791
 Glu Asn Lys Gly Leu Asp Val Leu Val Glu Tyr Leu Ser Phe Ala Gln
     130                 135                 140

 tac gcg gta act ttt gac ttt gaa agt gtg gag agt act gtg gag agc      839
 Tyr Ala Val Thr Phe Asp Phe Glu Ser Val Glu Ser Thr Val Glu Ser
 145                 150                 155                 160

 tcg gtg gac aaa tca aag ccc tgg agt agg tcc atc gag gac ctg cac      887
 Ser Val Asp Lys Ser Lys Pro Trp Ser Arg Ser Ile Glu Asp Leu His
                 165                 170                 175

 aga ggg agc aac ctg ccc tca cct gtg ggc aac agt gtc tcc cgc tct      935
 Arg Gly Ser Asn Leu Pro Ser Pro Val Gly Asn Ser Val Ser Arg Ser
             180                 185                 190

 gga aga cat tct gca ctg cga tat aat aca ttg cca agc aga aga act      983
 Gly Arg His Ser Ala Leu Arg Tyr Asn Thr Leu Pro Ser Arg Arg Thr
         195                 200                 205

 ctg aaa aat tca aga tta gtg agt aag aaa gat gat gtg cat gtc tgt     1031
 Leu Lys Asn Ser Arg Leu Val Ser Lys Lys Asp Asp Val His Val Cys
     210                 215                 220

 atc atg tgt tta cgt gcc atc atg aat tat cag tat ggt ttc aac atg     1079
 Ile Met Cys Leu Arg Ala Ile Met Asn Tyr Gln Tyr Gly Phe Asn Met
 225                 230                 235                 240

 gtc atg tct cat cca cac gct gtc aat gag att gca cta agc ctg aac     1127
 Val Met Ser His Pro His Ala Val Asn Glu Ile Ala Leu Ser Leu Asn
                 245                 250                 255

 aac aag aat ccc aga aca aaa gcc ctt gtc tta gaa ctg ttg gca gcc     1175
 Asn Lys Asn Pro Arg Thr Lys Ala Leu Val Leu Glu Leu Leu Ala Ala
             260                 265                 270

 gtt tgt ctt gtc aga ggc ggg cat gaa atc att tta tca gca ttt gat     1223
 Val Cys Leu Val Arg Gly Gly His Glu Ile Ile Leu Ser Ala Phe Asp
         275                 280                 285

 aac ttt aaa gag gtt tgt gga gaa aaa cag cgc ttt gag aag ttg atg     1271
 Asn Phe Lys Glu Val Cys Gly Glu Lys Gln Arg Phe Glu Lys Leu Met
     290                 295                 300

 gaa cat ttc agg aat gaa gac aat aac ata gat ttt atg gtg gct tct     1319
 Glu His Phe Arg Asn Glu Asp Asn Asn Ile Asp Phe Met Val Ala Ser
 305                 310                 315                 320

 atg cag ttt att aat att gta gtc cat tca gta gaa gat atg aat ttc     1367
 Met Gln Phe Ile Asn Ile Val Val His Ser Val Glu Asp Met Asn Phe
                 325                 330                 335

 aga gtt cac ctg cag tat gaa ttt acc aaa tta ggc ctg gac gaa tac     1415
 Arg Val His Leu Gln Tyr Glu Phe Thr Lys Leu Gly Leu Asp Glu Tyr
             340                 345                 350

 ttg gac aag ctg aaa cac act gag agt gac aag ctt caa gtc cag atc     1463
 Leu Asp Lys Leu Lys His Thr Glu Ser Asp Lys Leu Gln Val Gln Ile
         355                 360                 365

 cag gct tac ctg gac aat gtt ttt gat gta gga gct cta ctg gaa gat     1511
 Gln Ala Tyr Leu Asp Asn Val Phe Asp Val Gly Ala Leu Leu Glu Asp
     370                 375                 380

 gct gaa act aag aat gct gcc ttg gag agg gtg gaa gaa ctg gaa gaa     1559
 Ala Glu Thr Lys Asn Ala Ala Leu Glu Arg Val Glu Glu Leu Glu Glu
 385                 390                 395                 400

 aac att tct cat tta tct gaa aaa ctg caa gac aca gag aat gaa gcc     1607
 Asn Ile Ser His Leu Ser Glu Lys Leu Gln Asp Thr Glu Asn Glu Ala
                 405                 410                 415

 atg tcc aag att gtg gaa ctg gaa aag caa ctc atg cag agg aac aag     1655
 Met Ser Lys Ile Val Glu Leu Glu Lys Gln Leu Met Gln Arg Asn Lys
             420                 425                 430

 gag ctg gat gtc gtt cgg gaa atc tac aaa gat gca aat act caa gtt     1703
 Glu Leu Asp Val Val Arg Glu Ile Tyr Lys Asp Ala Asn Thr Gln Val
         435                 440                 445

 cac aca tta aga aaa atg gtc aaa gaa aaa gaa gaa gca att caa aga     1751
 His Thr Leu Arg Lys Met Val Lys Glu Lys Glu Glu Ala Ile Gln Arg
     450                 455                 460

 cag tct acc ctg gaa aaa aag att cat gag cta gag aaa caa ggg acc     1799
 Gln Ser Thr Leu Glu Lys Lys Ile His Glu Leu Glu Lys Gln Gly Thr
 465                 470                 475                 480

 att aaa att cag aag aaa ggg gat ggg gat atc gcc ata ctg cca gtt     1847
 Ile Lys Ile Gln Lys Lys Gly Asp Gly Asp Ile Ala Ile Leu Pro Val
                 485                 490                 495

 gtg gct tct ggc aca ttg tcc atg ggg tca gaa gtg gta gca gtg gtt     1895
 Val Ala Ser Gly Thr Leu Ser Met Gly Ser Glu Val Val Ala Val Val
             500                 505                 510

 ttc aac tca gga tta gca ggt aag agc acc gaa ttc aaa ccc agg tac     1943
 Phe Asn Ser Gly Leu Ala Gly Lys Ser Thr Glu Phe Lys Pro Arg Tyr
         515                 520                 525

 tca tat cag aaa tgc tgt ctt atc tcg gag agt tga                     1979
 Ser Tyr Gln Lys Cys Cys Leu Ile Ser Glu Ser 
     530                 535





      <210> 230
      <211> 1761
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (728)..(1627)

      <400> 230
 tgtgagaagt ttctgggata ttggttcact cagcactgat gtttaaaaat gccttctatg     60

 tgccagacgc tgttgtaggt accgggaata tggcggttaa attaagaggg tgaaggtttc    120

 tgctctgata cagtttatat tctaaatgtg agaggacaga ccagttagat agatgtaaat    180

 taaataatta aatagatgat ttttacatac tgtagagcta tagagaaaat atagctggat    240

 gggtgatagt gacttgggga tgggggtggc tactctggat agggtagttt aaggtgacat    300

 ctctgtgcag atgtagaatg ggctagtgct ttctaagaac tgaaagatca gtgaagaagg    360

 ggagcatagt gactgaggag tagtgtggca ttagatgggg tctgagagtt acacaggaac    420

 atgtggagcc tgtaggccat ggtaaagcct ttttctactc ttctggtgat ttaaagccat    480

 tgtaaagttt tgagcttggg agtaggtagc aaaataagat ttatattttt atggggttac    540

 tctggctgtt gagaggagaa aaagacatga atctgggagg ccacttggga agcaaggcca    600

 tcagtgaaga gaaagagtgg gagaaaaagg tttgaggaga gaaggtatag gactttcact    660

 aaccttggac catatatttg ccaggaagaa tgtaagttct ccaacatctt caaataaaga    720

 agtggtt  atg agg aat gat cag aat aat gga gat atg aaa cca ttc cag     769
          Met Arg Asn Asp Gln Asn Asn Gly Asp Met Lys Pro Phe Gln
            1               5                  10

 aat ttc aca aca ata cca atc aca cag gct ctc aac tac aat ctg agc      817
 Asn Phe Thr Thr Ile Pro Ile Thr Gln Ala Leu Asn Tyr Asn Leu Ser
  15                  20                  25                  30

 aaa gaa ggg cat tta gaa aaa gaa cct tgg aat gca ttc agc cat cat      865
 Lys Glu Gly His Leu Glu Lys Glu Pro Trp Asn Ala Phe Ser His His
                  35                  40                  45

 ggc cca gtt aat gtc tcc atc aat gga att cct tgc att ctc ttc tgg      913
 Gly Pro Val Asn Val Ser Ile Asn Gly Ile Pro Cys Ile Leu Phe Trp
              50                  55                  60

 gcc aaa aga ata atg att aaa ttt aag aat caa acc tgg ctg gac ctt      961
 Ala Lys Arg Ile Met Ile Lys Phe Lys Asn Gln Thr Trp Leu Asp Leu
          65                  70                  75

 aca gac gag cca ttt ggt cag aag gta act gtg gac cct gac aac tca     1009
 Thr Asp Glu Pro Phe Gly Gln Lys Val Thr Val Asp Pro Asp Asn Ser
      80                  85                  90

 aat tgc agt gaa gaa agt gct agg ttg tct ttg aag ctt ggt gat gct     1057
 Asn Cys Ser Glu Glu Ser Ala Arg Leu Ser Leu Lys Leu Gly Asp Ala
  95                 100                 105                 110

 gga aac ccc aga agt ctt gct ata aga ttc atc ctt acc aat tac aac     1105
 Gly Asn Pro Arg Ser Leu Ala Ile Arg Phe Ile Leu Thr Asn Tyr Asn
                 115                 120                 125

 aag ttg tcc atc cag agt tgg ttt agt ttg cgc cga gtc gag atc att     1153
 Lys Leu Ser Ile Gln Ser Trp Phe Ser Leu Arg Arg Val Glu Ile Ile
             130                 135                 140

 tcc aac aat tca atc caa gca gtc ttt aac cca act ggc gta tat gct     1201
 Ser Asn Asn Ser Ile Gln Ala Val Phe Asn Pro Thr Gly Val Tyr Ala
         145                 150                 155

 ccc tct ggt tac tcc tac cgc tgc caa cgc gtg ggc agc ctg cag cag     1249
 Pro Ser Gly Tyr Ser Tyr Arg Cys Gln Arg Val Gly Ser Leu Gln Gln
     160                 165                 170

 gac cag gcc ctc ttg ctg ccc agc gac acg gat gat ggg tcg agc ctg     1297
 Asp Gln Ala Leu Leu Leu Pro Ser Asp Thr Asp Asp Gly Ser Ser Leu
 175                 180                 185                 190

 tgg gag gtc act ttt att gat ttc cag atc caa ggt ttt gcc atc aag     1345
 Trp Glu Val Thr Phe Ile Asp Phe Gln Ile Gln Gly Phe Ala Ile Lys
                 195                 200                 205

 ggg gga cga ttt acc aaa gcc caa gac tgc gcc tcc tcc ttc tcg cca     1393
 Gly Gly Arg Phe Thr Lys Ala Gln Asp Cys Ala Ser Ser Phe Ser Pro
             210                 215                 220

 gct ttt ctg atc ggc ctg gca atg tcc ctg atc ctg ctg ctg gtg ttg     1441
 Ala Phe Leu Ile Gly Leu Ala Met Ser Leu Ile Leu Leu Leu Val Leu
         225                 230                 235

 gcc tat gcc ctg cac atg ctc atc tac ctg cgg tat ctg gac caa caa     1489
 Ala Tyr Ala Leu His Met Leu Ile Tyr Leu Arg Tyr Leu Asp Gln Gln
     240                 245                 250

 tat gat ctc atc gcc tct cct gcc cac ttc tcg cag ctg aaa gct cga     1537
 Tyr Asp Leu Ile Ala Ser Pro Ala His Phe Ser Gln Leu Lys Ala Arg
 255                 260                 265                 270

 gac aca gcc gaa gag aag gag ctg ctg agg agc cag ggg gct gaa tgc     1585
 Asp Thr Ala Glu Glu Lys Glu Leu Leu Arg Ser Gln Gly Ala Glu Cys
                 275                 280                 285

 tat aaa ctg aga agc caa cag atc agc aaa atc tat gtt tag cagcaca     1634
 Tyr Lys Leu Arg Ser Gln Gln Ile Ser Lys Ile Tyr Val 
             290                 295

 ggctggcccc caccatgtcc acagtgggct ccgaaagttg tctctgttct gtgctatttg   1694

 acttgtgaat tacagatttt caccaaatgg cttgattaca aaaaaaaaaa aaaaaaacaa   1754

 catcagc                                                             1761




      <210> 231
      <211> 2835
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (1)..(2835)

      <400> 231
  atg aca ctg aac cag ttc cag gtc cag atg tta agg aaa cta gaa gct      48
  Met Thr Leu Asn Gln Phe Gln Val Gln Met Leu Arg Lys Leu Glu Ala
    1               5                  10                  15

 tct gct ttt gta ccc tta gaa cta gaa gac cac cat gct aac aaa gct       96
 Ser Ala Phe Val Pro Leu Glu Leu Glu Asp His His Ala Asn Lys Ala
              20                  25                  30

 cgc cga gag gac ttc tgt cct cgg aag ctg cgg cag atg cac ctg atg      144
 Arg Arg Glu Asp Phe Cys Pro Arg Lys Leu Arg Gln Met His Leu Met
          35                  40                  45

 att gac cag ctc atg gcc cac tcc cac ctg cgt tac aag gga act ctg      192
 Ile Asp Gln Leu Met Ala His Ser His Leu Arg Tyr Lys Gly Thr Leu
      50                  55                  60

 tcc atg tta caa tgc aat gtc ttc ccg ggg ctt cca cct gac ttc ctg      240
 Ser Met Leu Gln Cys Asn Val Phe Pro Gly Leu Pro Pro Asp Phe Leu
  65                  70                  75                  80

 gac tct gag gtc aac tta ttc ctg gta ccc ttc atg gac agt gaa gca      288
 Asp Ser Glu Val Asn Leu Phe Leu Val Pro Phe Met Asp Ser Glu Ala
                  85                  90                  95

 gag agt gaa aac cca cca aga gca ggt aca gtt acc ctc aac agt ttc      336
 Glu Ser Glu Asn Pro Pro Arg Ala Gly Thr Val Thr Leu Asn Ser Phe
             100                 105                 110

 cag tcc ttg gtg agc aag ctc cgg agc caa gtg atg tcc atg gcc cgg      384
 Gln Ser Leu Val Ser Lys Leu Arg Ser Gln Val Met Ser Met Ala Arg
         115                 120                 125

 cca cag ctg tca cac acg atc ctc acc gag aag aac tgc tca ggg ctg      432
 Pro Gln Leu Ser His Thr Ile Leu Thr Glu Lys Asn Cys Ser Gly Leu
     130                 135                 140

 aga ttg ttg att gga ttc acc tgt gat ctt gtg gtc agt gtt gcc aag      480
 Arg Leu Leu Ile Gly Phe Thr Cys Asp Leu Val Val Ser Val Ala Lys
 145                 150                 155                 160

 gaa ggt ctg aat cag cac act ctt ggt gtc cct ggc tgc caa atc cag      528
 Glu Gly Leu Asn Gln His Thr Leu Gly Val Pro Gly Cys Gln Ile Gln
                 165                 170                 175

 ggg cgt gtg aag cat ccg gta gat ggt ggt gaa gga ggt gct gca gag      576
 Gly Arg Val Lys His Pro Val Asp Gly Gly Glu Gly Gly Ala Ala Glu
             180                 185                 190

 gat aat cac tac tgc ctt cag atg gca ggc atc aca ggc ttt ggc gaa      624
 Asp Asn His Tyr Cys Leu Gln Met Ala Gly Ile Thr Gly Phe Gly Glu
         195                 200                 205

 ggt aac cct gtc tcc tgg aga aac ggt ttc tgc gtg acc tcc aag gac      672
 Gly Asn Pro Val Ser Trp Arg Asn Gly Phe Cys Val Thr Ser Lys Asp
     210                 215                 220

 tgc aaa ttt ggc aac tcc atc tat gcc ctg acc tat ggt gtt ggc ttt      720
 Cys Lys Phe Gly Asn Ser Ile Tyr Ala Leu Thr Tyr Gly Val Gly Phe
 225                 230                 235                 240

 ggc ttc tgc gtc aac acc acc tgt tgc caa ggc aac tac cag gag ccc      768
 Gly Phe Cys Val Asn Thr Thr Cys Cys Gln Gly Asn Tyr Gln Glu Pro
                 245                 250                 255

 acc cct ctc gca gct cat ctg gcc tca cac acc ctg agt gag ata ttg      816
 Thr Pro Leu Ala Ala His Leu Ala Ser His Thr Leu Ser Glu Ile Leu
             260                 265                 270

 tgt cct aca tgt cct ggg agc tac ttg gag ccc tgc aat tcc tcc ttc      864
 Cys Pro Thr Cys Pro Gly Ser Tyr Leu Glu Pro Cys Asn Ser Ser Phe
         275                 280                 285

 tac atg cag tgt ccc agt ggg gaa tct gag tgt gtc cag ctg gac cta      912
 Tyr Met Gln Cys Pro Ser Gly Glu Ser Glu Cys Val Gln Leu Asp Leu
     290                 295                 300

 acg tct gaa gaa ggc ggc cgg aac gtg aac gta cgc ggc tgc ggc tcc      960
 Thr Ser Glu Glu Gly Gly Arg Asn Val Asn Val Arg Gly Cys Gly Ser
 305                 310                 315                 320

 cga gac ctg tgc agc gcc ctg gac tgg acc cac ggg ctc tct gtg ctc     1008
 Arg Asp Leu Cys Ser Ala Leu Asp Trp Thr His Gly Leu Ser Val Leu
                 325                 330                 335

 cca aga cac tgg gct gta gag cca ctg cag ccc cca ccg ccg cgc cgt     1056
 Pro Arg His Trp Ala Val Glu Pro Leu Gln Pro Pro Pro Pro Arg Arg
             340                 345                 350

 cat aga tcc tgg caa ccg cga cgc tgt gat aag gaa tcc cgc ctg gac     1104
 His Arg Ser Trp Gln Pro Arg Arg Cys Asp Lys Glu Ser Arg Leu Asp
         355                 360                 365

 cac ccc gcc gcc cgg gag gcc ccc tcc acc tgc ttg ttc ggc acg tcg     1152
 His Pro Ala Ala Arg Glu Ala Pro Ser Thr Cys Leu Phe Gly Thr Ser
     370                 375                 380

 ata gat ggt gcc ctg gct ccc ctc tgc tgg ggc aat gcg gag acc tgg     1200
 Ile Asp Gly Ala Leu Ala Pro Leu Cys Trp Gly Asn Ala Glu Thr Trp
 385                 390                 395                 400

 aag cct ctg gta acc atg tct gag tct gga cac agt cag cct gga ctc     1248
 Lys Pro Leu Val Thr Met Ser Glu Ser Gly His Ser Gln Pro Gly Leu
                 405                 410                 415

 tat ggg ata gag cgg cgg cga cgg tgg aag gag cct ggc tct ggt ggc     1296
 Tyr Gly Ile Glu Arg Arg Arg Arg Trp Lys Glu Pro Gly Ser Gly Gly
             420                 425                 430

 ccc cag aat ctc tct ggg cct ggt ggt cgg gag agg gac tac att gca     1344
 Pro Gln Asn Leu Ser Gly Pro Gly Gly Arg Glu Arg Asp Tyr Ile Ala
         435                 440                 445

 cca tgg gaa aga gag aga agg gat gcc agc gaa gag aca agc act tcc     1392
 Pro Trp Glu Arg Glu Arg Arg Asp Ala Ser Glu Glu Thr Ser Thr Ser
     450                 455                 460

 gtc atg cag aaa acc ccc atc atc ctc tca aaa cct cca gca gag cgg     1440
 Val Met Gln Lys Thr Pro Ile Ile Leu Ser Lys Pro Pro Ala Glu Arg
 465                 470                 475                 480

 tca aaa cag cca cca cct cca aca gcc cct gct gcc ccg cct gct cca     1488
 Ser Lys Gln Pro Pro Pro Pro Thr Ala Pro Ala Ala Pro Pro Ala Pro
                 485                 490                 495

 gcc cct ctg gag aag ccc atc gtt ctc atg aag cca cgg gag gag ggg     1536
 Ala Pro Leu Glu Lys Pro Ile Val Leu Met Lys Pro Arg Glu Glu Gly
             500                 505                 510

 aag ggg cct gtg gcc gtg aca ggt gcc tct acc cct gag ggc acc gcc     1584
 Lys Gly Pro Val Ala Val Thr Gly Ala Ser Thr Pro Glu Gly Thr Ala
         515                 520                 525

 cca cca ccc cct gca gcc cct gcg cca ccc aag ggg gag aag gag ggg     1632
 Pro Pro Pro Pro Ala Ala Pro Ala Pro Pro Lys Gly Glu Lys Glu Gly
     530                 535                 540

 cag aga ccc aca cag cct gtg tac cag atc cag aac cgg ggc atg ggc     1680
 Gln Arg Pro Thr Gln Pro Val Tyr Gln Ile Gln Asn Arg Gly Met Gly
 545                 550                 555                 560

 act gcc gca cca gca gcc atg gac cct gtc gtg ggt cag gcc aaa cta     1728
 Thr Ala Ala Pro Ala Ala Met Asp Pro Val Val Gly Gln Ala Lys Leu
                 565                 570                 575

 ctg ccc cca gag cgc atg aag cac agc atc aag ttg gtg gat gac cag     1776
 Leu Pro Pro Glu Arg Met Lys His Ser Ile Lys Leu Val Asp Asp Gln
             580                 585                 590

 atg aat tgg tgt gac agt gcc atc gag tac ctg ttg gat cag act gat     1824
 Met Asn Trp Cys Asp Ser Ala Ile Glu Tyr Leu Leu Asp Gln Thr Asp
         595                 600                 605

 gtg ttg gtg gtt ggt gtc ctg ggc ctc cag ggg aca ggc aag tcc atg     1872
 Val Leu Val Val Gly Val Leu Gly Leu Gln Gly Thr Gly Lys Ser Met
     610                 615                 620

 gtc atg tca ttg ttg tca gcc aac act cca gag gag gac cag agg act     1920
 Val Met Ser Leu Leu Ser Ala Asn Thr Pro Glu Glu Asp Gln Arg Thr
 625                 630                 635                 640

 tat gtt ttc cgg gcc cag agc gct gaa atg aag gaa cga ggg ggc aac     1968
 Tyr Val Phe Arg Ala Gln Ser Ala Glu Met Lys Glu Arg Gly Gly Asn
                 645                 650                 655

 cag acc agt ggc atc gac ttc ttt att acc caa gaa cgg att gtt ttc     2016
 Gln Thr Ser Gly Ile Asp Phe Phe Ile Thr Gln Glu Arg Ile Val Phe
             660                 665                 670

 ctg gac aca cag ccc atc ctg agc cct tct atc cta gac cat ctc atc     2064
 Leu Asp Thr Gln Pro Ile Leu Ser Pro Ser Ile Leu Asp His Leu Ile
         675                 680                 685

 aat aat gac cgc aaa ctg cct cca gag tac aac ctt ccc cac act tac     2112
 Asn Asn Asp Arg Lys Leu Pro Pro Glu Tyr Asn Leu Pro His Thr Tyr
     690                 695                 700

 gtt gaa atg cag tca ctc cag att gct gcc ttc ctt ttc acg gtc tgc     2160
 Val Glu Met Gln Ser Leu Gln Ile Ala Ala Phe Leu Phe Thr Val Cys
 705                 710                 715                 720

 cat gtg gtg att gtt gtc cag gac tgg ttc aca gac ctc agt ctc tac     2208
 His Val Val Ile Val Val Gln Asp Trp Phe Thr Asp Leu Ser Leu Tyr
                 725                 730                 735

 agg ctg tgg gac ctg ggg tgc aag tgc aag agc aac agc cac tca ccc     2256
 Arg Leu Trp Asp Leu Gly Cys Lys Cys Lys Ser Asn Ser His Ser Pro
             740                 745                 750

 caa acc cca agg ttc ctg cag aca gca gag atg gtg aag ccc tcc acc     2304
 Gln Thr Pro Arg Phe Leu Gln Thr Ala Glu Met Val Lys Pro Ser Thr
         755                 760                 765

 cca tcc ccc agc cac gag tcc agc agc tca tcg ggc tcc gat gaa ggc     2352
 Pro Ser Pro Ser His Glu Ser Ser Ser Ser Ser Gly Ser Asp Glu Gly
     770                 775                 780

 acc gag tac tac ccc cac cta gtc ttc ttg cag aac aaa gct cgc cga     2400
 Thr Glu Tyr Tyr Pro His Leu Val Phe Leu Gln Asn Lys Ala Arg Arg
 785                 790                 795                 800

 gag gac ttc tgt cct cgg aag ctg cgg cag atg cac ctg atg att gac     2448
 Glu Asp Phe Cys Pro Arg Lys Leu Arg Gln Met His Leu Met Ile Asp
                 805                 810                 815

 cag ctc atg gcc cac tcc cac ctg cgt tac aag gga act ctg tcc atg     2496
 Gln Leu Met Ala His Ser His Leu Arg Tyr Lys Gly Thr Leu Ser Met
             820                 825                 830

 tta caa tgc aat gtc ttc ccg ggg ctt cca cct gac ttc ctg gac tct     2544
 Leu Gln Cys Asn Val Phe Pro Gly Leu Pro Pro Asp Phe Leu Asp Ser
         835                 840                 845

 gag gtc aac tta ttc ctg gta ccc ttc atg gac agt gaa gca gag agt     2592
 Glu Val Asn Leu Phe Leu Val Pro Phe Met Asp Ser Glu Ala Glu Ser
     850                 855                 860

 gaa aac cca cca aga gca gga cct ggt tcc agc cca ctc ttc tcc ctg     2640
 Glu Asn Pro Pro Arg Ala Gly Pro Gly Ser Ser Pro Leu Phe Ser Leu
 865                 870                 875                 880

 ctg cct ggg tat cgt ggc cac ccc agt ttc cag tcc ttg gtg agc aag     2688
 Leu Pro Gly Tyr Arg Gly His Pro Ser Phe Gln Ser Leu Val Ser Lys
                 885                 890                 895

 ctc cgg agc caa gtg atg tcc atg gcc cgg cca cag ctg tca cac acg     2736
 Leu Arg Ser Gln Val Met Ser Met Ala Arg Pro Gln Leu Ser His Thr
             900                 905                 910

 atc ctc acc gag aag aac tgg ttc cac tac gct gcc cgg atc tgg gat     2784
 Ile Leu Thr Glu Lys Asn Trp Phe His Tyr Ala Ala Arg Ile Trp Asp
         915                 920                 925

 ggg gtg aga aag tcc tct gct ctg gca gag tac agc cgc ctg ctg gcc     2832
 Gly Val Arg Lys Ser Ser Ala Leu Ala Glu Tyr Ser Arg Leu Leu Ala
     930                 935                 940

 tga                                                                 2835
 






      <210> 232
      <211> 1146
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (46)..(1146)

      <400> 232
 acagctttct acacctttac tccctgcaaa gaaacaatag tgctt    atg cca gct      54
                                                      Met Pro Ala
                                                        1

 aag ctc cag ggt aat ggt atc atg aca gct tca act ttt aga cca cag      102
 Lys Leu Gln Gly Asn Gly Ile Met Thr Ala Ser Thr Phe Arg Pro Gln
       5                  10                  15

 gcg aat gct ttg aac cat aaa tcc atg gct aac ctt gac aaa tac act      150
 Ala Asn Ala Leu Asn His Lys Ser Met Ala Asn Leu Asp Lys Tyr Thr
  20                  25                  30                  35

 gaa aca ttc aag atg ggt agc aac agt acc agc act gct gag att tac      198
 Glu Thr Phe Lys Met Gly Ser Asn Ser Thr Ser Thr Ala Glu Ile Tyr
                  40                  45                  50

 tgt aat gtc act aat gtg aaa ttt caa tac tcc ctc tat gca acc acc      246
 Cys Asn Val Thr Asn Val Lys Phe Gln Tyr Ser Leu Tyr Ala Thr Thr
              55                  60                  65

 tat atc ctc ata ttc att cct ggt ctt ctg gct aac agt gca gcc ttg      294
 Tyr Ile Leu Ile Phe Ile Pro Gly Leu Leu Ala Asn Ser Ala Ala Leu
          70                  75                  80

 tgg gtt ctg tgc cgc ttc atc agc aag aaa aat aaa gcc atc att ttc      342
 Trp Val Leu Cys Arg Phe Ile Ser Lys Lys Asn Lys Ala Ile Ile Phe
      85                  90                  95

 atg atc aac ctc tct gtg gct gac ctt gct cat gta tta tct tta ccc      390
 Met Ile Asn Leu Ser Val Ala Asp Leu Ala His Val Leu Ser Leu Pro
 100                 105                 110                 115

 ctc cgg att tac tat tac atc agc cac cac tgg cct ttc cag aga gcc      438
 Leu Arg Ile Tyr Tyr Tyr Ile Ser His His Trp Pro Phe Gln Arg Ala
                 120                 125                 130

 ctt tgc ctg ctc tgc ttc tac ctg aag tat ctc aac atg tat gcc agc      486
 Leu Cys Leu Leu Cys Phe Tyr Leu Lys Tyr Leu Asn Met Tyr Ala Ser
             135                 140                 145

 att tgt ttc ctg acg tgc atc agt ctt caa agg tgc ttt ttt ctc ctc      534
 Ile Cys Phe Leu Thr Cys Ile Ser Leu Gln Arg Cys Phe Phe Leu Leu
         150                 155                 160

 aag ccc ttc agg gcc aga gac tgg aag cgt agg tac gat gtg ggc atc      582
 Lys Pro Phe Arg Ala Arg Asp Trp Lys Arg Arg Tyr Asp Val Gly Ile
     165                 170                 175

 agt gct gcc atc tgg atc gtt gtg ggg act gcc tgt ttg cca ttt ccc      630
 Ser Ala Ala Ile Trp Ile Val Val Gly Thr Ala Cys Leu Pro Phe Pro
 180                 185                 190                 195

 atc ctg aga agc aca gac tta aac aac aac aag tcc tgc ttt gct gat      678
 Ile Leu Arg Ser Thr Asp Leu Asn Asn Asn Lys Ser Cys Phe Ala Asp
                 200                 205                 210

 ctt gga tac aag caa atg aat gca gtt gcg ttg gtc ggg atg att aca      726
 Leu Gly Tyr Lys Gln Met Asn Ala Val Ala Leu Val Gly Met Ile Thr
             215                 220                 225

 gtt gct gag ctt gca gga ttt gtg atc cca gtg atc atc atc gca tgg      774
 Val Ala Glu Leu Ala Gly Phe Val Ile Pro Val Ile Ile Ile Ala Trp
         230                 235                 240

 tgt acc tgg aaa act act ata tcc ttg aga cag cca cca atg gct ttc      822
 Cys Thr Trp Lys Thr Thr Ile Ser Leu Arg Gln Pro Pro Met Ala Phe
     245                 250                 255

 caa ggg atc agt gag agg cag aaa gca ctg cgg atg gtg ttc atg tgt      870
 Gln Gly Ile Ser Glu Arg Gln Lys Ala Leu Arg Met Val Phe Met Cys
 260                 265                 270                 275

 gct gca gtc ttc ttc atc tgc ttc act ccc tat cat att aac ttt att      918
 Ala Ala Val Phe Phe Ile Cys Phe Thr Pro Tyr His Ile Asn Phe Ile
                 280                 285                 290

 ttt tac acc atg gta aag gaa acc atc att agc agt tgt ccc gtt gtc      966
 Phe Tyr Thr Met Val Lys Glu Thr Ile Ile Ser Ser Cys Pro Val Val
             295                 300                 305

 cga atc gca ctg tat ttc cac cct ttt tgc ctg tgc ctt gca agt ctc     1014
 Arg Ile Ala Leu Tyr Phe His Pro Phe Cys Leu Cys Leu Ala Ser Leu
         310                 315                 320

 tgc tgc ctt ttg gat cca att ctt tat tac ttt atg gct tca gag ttt     1062
 Cys Cys Leu Leu Asp Pro Ile Leu Tyr Tyr Phe Met Ala Ser Glu Phe
     325                 330                 335

 cgt gac caa cta tcc cgc cat ggc agt tct gtg acc cgc tcc cgc ctc     1110
 Arg Asp Gln Leu Ser Arg His Gly Ser Ser Val Thr Arg Ser Arg Leu
 340                 345                 350                 355

 atg agc aag gag agt ggt tca tca atg att ggc taa                     1146
 Met Ser Lys Glu Ser Gly Ser Ser Met Ile Gly 
                 360                 365





      <210> 233
      <211> 747
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (1)..(747)

      <400> 233
  atg gca cct aag gcg gca aag ggg gcc aag cca gag cca gca cca gct      48
  Met Ala Pro Lys Ala Ala Lys Gly Ala Lys Pro Glu Pro Ala Pro Ala
    1               5                  10                  15

 cca cct cca ccc ggg gcc aaa ccc gag gaa gac aag aag gac ggt aag       96
 Pro Pro Pro Pro Gly Ala Lys Pro Glu Glu Asp Lys Lys Asp Gly Lys
              20                  25                  30

 gag cca tcg gac aaa cct caa aag gcg gtg cag gac cat aag gag cca      144
 Glu Pro Ser Asp Lys Pro Gln Lys Ala Val Gln Asp His Lys Glu Pro
          35                  40                  45

 tcg gac aaa cct caa aag gcg gtg cag ccc aag cac gaa gtg ggc acg      192
 Ser Asp Lys Pro Gln Lys Ala Val Gln Pro Lys His Glu Val Gly Thr
      50                  55                  60

 agg agg ggg tgt cgc cgc tac cgg tgg gaa tta aaa gac agc aat aaa      240
 Arg Arg Gly Cys Arg Arg Tyr Arg Trp Glu Leu Lys Asp Ser Asn Lys
  65                  70                  75                  80

 gag ttc tgg ctc ttg ggg cac gct gag atc aag att cgg agt ttg ggc      288
 Glu Phe Trp Leu Leu Gly His Ala Glu Ile Lys Ile Arg Ser Leu Gly
                  85                  90                  95

 tgc cta ata gct gca atg ata ctg ttg tcc tca ctc acc gtg cac ccc      336
 Cys Leu Ile Ala Ala Met Ile Leu Leu Ser Ser Leu Thr Val His Pro
             100                 105                 110

 atc ttg agg ctt atc atc acc atg gag ata tcc ttc ttc agc ttc ttc      384
 Ile Leu Arg Leu Ile Ile Thr Met Glu Ile Ser Phe Phe Ser Phe Phe
         115                 120                 125

 atc tta ctg tac agc ttt gcc att cat aga tac ata ccc ttc atc ctg      432
 Ile Leu Leu Tyr Ser Phe Ala Ile His Arg Tyr Ile Pro Phe Ile Leu
     130                 135                 140

 tgg ccc att tct gac ctc ttc aac gac ctg att gct tgt gcg ttc ctt      480
 Trp Pro Ile Ser Asp Leu Phe Asn Asp Leu Ile Ala Cys Ala Phe Leu
 145                 150                 155                 160

 gtg gga gcc gtg gtc ttt gct gtg aga agt cgg cga tcc atg aat ctc      528
 Val Gly Ala Val Val Phe Ala Val Arg Ser Arg Arg Ser Met Asn Leu
                 165                 170                 175

 cac tac tta ctt gct gtg atc ctt att ggt gcg gct gga gtt ttt gct      576
 His Tyr Leu Leu Ala Val Ile Leu Ile Gly Ala Ala Gly Val Phe Ala
             180                 185                 190

 ttt atc gat gtg tgt ctt caa aga aac cac ttc aga ggc aag aag gcc      624
 Phe Ile Asp Val Cys Leu Gln Arg Asn His Phe Arg Gly Lys Lys Ala
         195                 200                 205

 aaa aag cat atg ctg gtt cct cct cca gga aag gaa aaa gga ccc cag      672
 Lys Lys His Met Leu Val Pro Pro Pro Gly Lys Glu Lys Gly Pro Gln
     210                 215                 220

 cag ggc aag gga cca gaa ccc gcc aag cca cca gaa cct ggc aag cca      720
 Gln Gly Lys Gly Pro Glu Pro Ala Lys Pro Pro Glu Pro Gly Lys Pro
 225                 230                 235                 240

 cca ggg cca gca aag gga aag aaa tga                                  747
 Pro Gly Pro Ala Lys Gly Lys Lys 
                 245





      <210> 234
      <211> 2964
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (57)..(2543)

      <400> 234
 cttccccagt ggatgggaag ctgtatcagc acatctgcac cattttcccc cttttc         56                                                                 
 atg ctg tta aat tcc ttc tcc ttc agc atc atg gat gta agc cat atc      104
 Met Leu Leu Asn Ser Phe Ser Phe Ser Ile Met Asp Val Ser His Ile
   1               5                  10                  15

 att ctc cct act att cca atg gcc atc atc tac cag cct cct atg ttc      152
 Ile Leu Pro Thr Ile Pro Met Ala Ile Ile Tyr Gln Pro Pro Met Phe
              20                  25                  30

 tct cag ttg ctg aag gct ttg cag act gat gtc ccc aca cca gct acc      200
 Ser Gln Leu Leu Lys Ala Leu Gln Thr Asp Val Pro Thr Pro Ala Thr
          35                  40                  45

 caa tta cta tgg cca aac ttt aac cct att cat cac tca caa ttg ctc      248
 Gln Leu Leu Trp Pro Asn Phe Asn Pro Ile His His Ser Gln Leu Leu
      50                  55                  60

 cac ctg ttg aag aaa ttc ctt aaa ttc cag tat ctc tct tac cta att      296
 His Leu Leu Lys Lys Phe Leu Lys Phe Gln Tyr Leu Ser Tyr Leu Ile
  65                  70                  75                  80

 gga gcc aag ctg aca agg gag tct gag aaa tct aaa gag ttt aaa agt      344
 Gly Ala Lys Leu Thr Arg Glu Ser Glu Lys Ser Lys Glu Phe Lys Ser
                  85                  90                  95

 att gat att ggc cag att ttc caa atg aaa acc gcc atc aag aag aaa      392
 Ile Asp Ile Gly Gln Ile Phe Gln Met Lys Thr Ala Ile Lys Lys Lys
             100                 105                 110

 aga gga gct gcc aag gcc atg tct gtt cca tca tca ctg agc cag tcg      440
 Arg Gly Ala Ala Lys Ala Met Ser Val Pro Ser Ser Leu Ser Gln Ser
         115                 120                 125

 gcc att aat gcc aac agc cac gga ggc ccc gca ctg agc cta ccc ctg      488
 Ala Ile Asn Ala Asn Ser His Gly Gly Pro Ala Leu Ser Leu Pro Leu
     130                 135                 140

 cct ctg cac gct gcc cac aac cag ctg ctc aac gcc aag ctg cag gcc      536
 Pro Leu His Ala Ala His Asn Gln Leu Leu Asn Ala Lys Leu Gln Ala
 145                 150                 155                 160

 aca gct gtg gga ccc aag gac ctg cgc agc gcc atg ggg gag ggt ggt      584
 Thr Ala Val Gly Pro Lys Asp Leu Arg Ser Ala Met Gly Glu Gly Gly
                 165                 170                 175

 ggg cct gag cca ggc cct gcc aat gcc aag tgg cta aaa gag ggc cag      632
 Gly Pro Glu Pro Gly Pro Ala Asn Ala Lys Trp Leu Lys Glu Gly Gln
             180                 185                 190

 aac cag ctc cgg cgg gcc gcc acg gcc cac cgt gac cag aat cgc aat      680
 Asn Gln Leu Arg Arg Ala Ala Thr Ala His Arg Asp Gln Asn Arg Asn
         195                 200                 205

 gtg acc ttg acc ttg gcg gag gag gcc agc cag gag cct gag atg gca      728
 Val Thr Leu Thr Leu Ala Glu Glu Ala Ser Gln Glu Pro Glu Met Ala
     210                 215                 220

 ccc ttg ggc ccc aaa ggc ctg ata cac ctg tac tct gag ctg gag ctc      776
 Pro Leu Gly Pro Lys Gly Leu Ile His Leu Tyr Ser Glu Leu Glu Leu
 225                 230                 235                 240

 tca gct cac aat gca gcc aac cga ggc cta cga gga cct ggc ctg atc      824
 Ser Ala His Asn Ala Ala Asn Arg Gly Leu Arg Gly Pro Gly Leu Ile
                 245                 250                 255

 atc agc act caa gag cag ggg cca gat gag gga gag gag aag gcg gcc      872
 Ile Ser Thr Gln Glu Gln Gly Pro Asp Glu Gly Glu Glu Lys Ala Ala
             260                 265                 270

 ggg gag gcc gag gag gag gag gag gat gat gat gat gaa gag gag gag      920
 Gly Glu Ala Glu Glu Glu Glu Glu Asp Asp Asp Asp Glu Glu Glu Glu
         275                 280                 285

 gag gac tta tct tct ccc cca ggg ctg cct gag ccc ctg gag agt gtg      968
 Glu Asp Leu Ser Ser Pro Pro Gly Leu Pro Glu Pro Leu Glu Ser Val
     290                 295                 300

 gag gcc cct ccc agg ccc caa gcc ctt aca gat ggc ccc cgg gaa cac     1016
 Glu Ala Pro Pro Arg Pro Gln Ala Leu Thr Asp Gly Pro Arg Glu His
 305                 310                 315                 320

 agc aag agt gcc agc ctc ctg ttt ggc atg cgg aac agt gca gcc agt     1064
 Ser Lys Ser Ala Ser Leu Leu Phe Gly Met Arg Asn Ser Ala Ala Ser
                 325                 330                 335

 gat gag gac tca agc tgg gct acc tta tcc cag ggc agc ccc tcc tat     1112
 Asp Glu Asp Ser Ser Trp Ala Thr Leu Ser Gln Gly Ser Pro Ser Tyr
             340                 345                 350

 ggc tcc cca gag gac aca gat tcc ttc tgg aac ccc aac gcc ttc gag     1160
 Gly Ser Pro Glu Asp Thr Asp Ser Phe Trp Asn Pro Asn Ala Phe Glu
         355                 360                 365

 acg gat tcc gac ctg ccg gct gga tgg atg agg gtc cag gac acc tca     1208
 Thr Asp Ser Asp Leu Pro Ala Gly Trp Met Arg Val Gln Asp Thr Ser
     370                 375                 380

 ggg acc tat tac tgg cac atc cca aca ggg acc acc cag tgg gaa ccc     1256
 Gly Thr Tyr Tyr Trp His Ile Pro Thr Gly Thr Thr Gln Trp Glu Pro
 385                 390                 395                 400

 ccc ggc cgg gcc tcc ccc tca cag ggg agc agc ccc caa gag gag tcc     1304
 Pro Gly Arg Ala Ser Pro Ser Gln Gly Ser Ser Pro Gln Glu Glu Ser
                 405                 410                 415

 cag ctc acc tgg aca ggt ttt gct cat gga gaa ggc ttt gag gat gga     1352
 Gln Leu Thr Trp Thr Gly Phe Ala His Gly Glu Gly Phe Glu Asp Gly
             420                 425                 430

 gaa ttt tgg aag gat gaa ccc agt gat gag gcc cca atg gag ctg gga     1400
 Glu Phe Trp Lys Asp Glu Pro Ser Asp Glu Ala Pro Met Glu Leu Gly
         435                 440                 445

 ctg aag gaa cct gag gag ggg acg ttg acc ttc cca gct cag agc ctc     1448
 Leu Lys Glu Pro Glu Glu Gly Thr Leu Thr Phe Pro Ala Gln Ser Leu
     450                 455                 460

 agc cca gag ccg ttg ccc caa gag gag gag aag ctt ccc cca cgg aat     1496
 Ser Pro Glu Pro Leu Pro Gln Glu Glu Glu Lys Leu Pro Pro Arg Asn
 465                 470                 475                 480

 acc aac cca ggg atc aag tgt ttc gcc gtg cgc tcc cta ggc tgg gta     1544
 Thr Asn Pro Gly Ile Lys Cys Phe Ala Val Arg Ser Leu Gly Trp Val
                 485                 490                 495

 gag atg acc gag gag gag ctg gcc cct gga cgc agc agt gtg gca gtc     1592
 Glu Met Thr Glu Glu Glu Leu Ala Pro Gly Arg Ser Ser Val Ala Val
             500                 505                 510

 aac aat tgc atc cgt cag ctc tct tac cac aaa aac aac ctg cat gac     1640
 Asn Asn Cys Ile Arg Gln Leu Ser Tyr His Lys Asn Asn Leu His Asp
         515                 520                 525

 ccc atg tct ggg ggc tgg ggg gaa gga aag gat ctg cta ctg cag ctg     1688
 Pro Met Ser Gly Gly Trp Gly Glu Gly Lys Asp Leu Leu Leu Gln Leu
     530                 535                 540

 gag gat gag aca cta aag cta gtg gag cca cag agc cag gca ctg ctg     1736
 Glu Asp Glu Thr Leu Lys Leu Val Glu Pro Gln Ser Gln Ala Leu Leu
 545                 550                 555                 560

 cac gcc caa ccc atc atc agc atc cgc gtg tgg ggc gtc ggg cgg gac     1784
 His Ala Gln Pro Ile Ile Ser Ile Arg Val Trp Gly Val Gly Arg Asp
                 565                 570                 575

 agt gga aga gag agg gac ttt gcc tac gta gct cgt gat aag ctg acc     1832
 Ser Gly Arg Glu Arg Asp Phe Ala Tyr Val Ala Arg Asp Lys Leu Thr
             580                 585                 590

 cag atg ctc aag tgc cac gtg ttt cgc tgt gag gca cct gcc aag aac     1880
 Gln Met Leu Lys Cys His Val Phe Arg Cys Glu Ala Pro Ala Lys Asn
         595                 600                 605

 atc gcc acc agc ctg cat gag atc tgc tct aag atc atg gcc gaa cgg     1928
 Ile Ala Thr Ser Leu His Glu Ile Cys Ser Lys Ile Met Ala Glu Arg
     610                 615                 620

 cgt aat gcc cgc tgc ttg gta aat gga ctc tcc ctg gac cac tct aaa     1976
 Arg Asn Ala Arg Cys Leu Val Asn Gly Leu Ser Leu Asp His Ser Lys
 625                 630                 635                 640

 ctt gtg gat gtc cct ttc caa gtg gaa ttc cca gcg cct aag aat gag     2024
 Leu Val Asp Val Pro Phe Gln Val Glu Phe Pro Ala Pro Lys Asn Glu
                 645                 650                 655

 ttg gtc cag aag ttc caa gtc tat tac ctg ggg aat gta cct gtt gct     2072
 Leu Val Gln Lys Phe Gln Val Tyr Tyr Leu Gly Asn Val Pro Val Ala
             660                 665                 670

 aaa cct gtt ggg gta gat gtg att aat ggg gcc ctc gag tca gtc ctg     2120
 Lys Pro Val Gly Val Asp Val Ile Asn Gly Ala Leu Glu Ser Val Leu
         675                 680                 685

 tcc tcc agc agc cgt gaa caa tgg acc cca agt cat gtc agt gtg gcc     2168
 Ser Ser Ser Ser Arg Glu Gln Trp Thr Pro Ser His Val Ser Val Ala
     690                 695                 700

 cct gct acc ctc acc atc ttg cac cag cag aca gag gca gtg ctg gga     2216
 Pro Ala Thr Leu Thr Ile Leu His Gln Gln Thr Glu Ala Val Leu Gly
 705                 710                 715                 720

 gag tgt cgg gtg cgt ttc ctc tcc ttc ctg gcc gtg ggc aga gat gtc     2264
 Glu Cys Arg Val Arg Phe Leu Ser Phe Leu Ala Val Gly Arg Asp Val
                 725                 730                 735

 cac acg ttt gca ttc atc atg gct gcc ggc cca gcc tcc ttc tgc tgc     2312
 His Thr Phe Ala Phe Ile Met Ala Ala Gly Pro Ala Ser Phe Cys Cys
             740                 745                 750

 cac atg ttc tgg tgc gag ccc aat gct gcc agc ctc tca gag gct gtg     2360
 His Met Phe Trp Cys Glu Pro Asn Ala Ala Ser Leu Ser Glu Ala Val
         755                 760                 765

 cag gct gcg tgc atg ctt cgc tac cag aag tgt ctg gat gcc cgt tcc     2408
 Gln Ala Ala Cys Met Leu Arg Tyr Gln Lys Cys Leu Asp Ala Arg Ser
     770                 775                 780

 cag gcc tcc acc tcc tgc ctc cca gca ccc cct gct gag tct gtg gca     2456
 Gln Ala Ser Thr Ser Cys Leu Pro Ala Pro Pro Ala Glu Ser Val Ala
 785                 790                 795                 800

 cgg cgt gta ggg tgg act gtc cgc agg ggt gtt cag tcg ctg tgg ggc     2504
 Arg Arg Val Gly Trp Thr Val Arg Arg Gly Val Gln Ser Leu Trp Gly
                 805                 810                 815

 tcc ctg aag ccc aaa cgg ctg ggg gcc cat acc cca tga agaagccccc      2553
 Ser Leu Lys Pro Lys Arg Leu Gly Ala His Thr Pro 
             820                 825

 accttccctt ccacctgatt gtgttgggcc ccagggaact aaagggtgtg ggtcagggag   2613

 gggtctagag gctattccta ggcctcaggc ctcccaaata tgcccctccc cagtagctac   2673

 ggttccctgc ctaggagctg gggagggaga gatctaatcc cttcaaggaa gtgataacac   2733

 tggagtggta acaagaggag caggaagcaa ggccagccct ggttctccat ccccatgtgt   2793

 ttcaggtgga acaggaggaa ctggtccagg ccaggcctca tcctcctgga cccagcaggg   2853

 gcagaaggag gaagggactg gtccaggcat gggtcccttc cccctgctcc atgggcacct   2913

 ctgctgtatt gatatcacta ataaagtctg tctgcactgc aaaaaaaaaa a            2964




      <210> 235
      <211> 1298
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (17)..(529)

      <400> 235
 gcacgagcct gagaac    atg gac gtt aat atc gcc cca ctc cgc gcc tgg      49
                      Met Asp Val Asn Ile Ala Pro Leu Arg Ala Trp
                        1               5                  10

 gac gat ttc ttc ccg ggt tcc gat cgc ttt gcc cgg ccg gac ttc agg       97
 Asp Asp Phe Phe Pro Gly Ser Asp Arg Phe Ala Arg Pro Asp Phe Arg
              15                  20                  25

 gac att tcc aaa tgg aac aac cgc gta gtg agc aac ctg ctc tat tac      145
 Asp Ile Ser Lys Trp Asn Asn Arg Val Val Ser Asn Leu Leu Tyr Tyr
          30                  35                  40

 cag acc aac tac ctg gtg gtg gct gcc atg atg att tcc att gtg ggg      193
 Gln Thr Asn Tyr Leu Val Val Ala Ala Met Met Ile Ser Ile Val Gly
      45                  50                  55

 ttt ctg agt ccc ttc aac atg atc ctg gga gga atc gtg gtg gtg ctg      241
 Phe Leu Ser Pro Phe Asn Met Ile Leu Gly Gly Ile Val Val Val Leu
  60                  65                  70                  75

 gtg ttc aca ggg ttt gtg tgg gca gcc cac aat aaa gac gtc ctt cgc      289
 Val Phe Thr Gly Phe Val Trp Ala Ala His Asn Lys Asp Val Leu Arg
                  80                  85                  90

 cgg atg aag aag cgc tac ccc acg acg ttc gtt atg gtg gtc atg ttg      337
 Arg Met Lys Lys Arg Tyr Pro Thr Thr Phe Val Met Val Val Met Leu
              95                 100                 105

 gcg agc tat ttc ctt atc tcc atg ttt gga gga gtc atg gtc ttt gtg      385
 Ala Ser Tyr Phe Leu Ile Ser Met Phe Gly Gly Val Met Val Phe Val
         110                 115                 120

 ttt ggc att act ttt cct ttg ctg ttg atg ttt atc cat gca tcg ttg      433
 Phe Gly Ile Thr Phe Pro Leu Leu Leu Met Phe Ile His Ala Ser Leu
     125                 130                 135

 aga ctt cgg aac ctc aag aac aaa ctg gag aat cta gaa cag cag gaa      481
 Arg Leu Arg Asn Leu Lys Asn Lys Leu Glu Asn Leu Glu Gln Gln Glu
 140                 145                 150                 155

 gaa ggc atc aac aga ctc act gac tat atc agc aaa gtg aag gaa taa      529
 Glu Gly Ile Asn Arg Leu Thr Asp Tyr Ile Ser Lys Val Lys Glu 
                 160                 165                 170

 acataactta cctgagctag ggttgcagca gaaattgagt tgcagcttgc ccttgtccag    589

 acctattttc tgcttgcgtt tttgaaacag gaggtgcacg taccacccaa ttatctatgg    649

 cagcatgcat gtataggccg aactattatc agctctgatg tttcagagag aagacctcag    709

 aaaccgaaag aaaaccacca ccctcctatt gtgtctgaag tttcacgtgt gtttatgaaa    769

 tctaatggga aatggatcac acgatttctt taagggaatt aaaaaaaata aaagaattac    829

 ggcttttaca gcaacaatac gattatctta taggaaaaaa aaaatcattg taaagtatca    889

 agacaatacg agtaaatgaa aaggctgtta aagtagatga catcatgtgt tagcctgttc    949

 ctaatcccct agaattgtaa tgtgtgggat ataaattagt ttttattatt ctcttaaaaa   1009

 tcaaagatga tctctatcac tttgccacct gtttgatgtg cagtggaaac tggttaagcc   1069

 agttgttcat acttcgttta caaatataaa gatagctgtt taggatattt tgttacattt   1129

 ttgtaaattt ttgaaatgct agtaatgtgt tttcaccagc aagtatttgt tgcaaactta   1189

 atgtcatttt ccttaagatg gttacagcta tgtaacctgt attattctgg acggacttat   1249

 taaaatacaa acagacaaaa aataaaacaa aacttgagtt ctaaaaaaa               1298




      <210> 236
      <211> 996
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (385)..(942)

      <400> 236
 caacctctca gggcttgttc tagtggctcc gaaagccagt gggagcaagc gcgctttgca     60

 aagccttggg cgccgggcct tggcgcgcct ttgccggatc cttccggcca cgggcggggc    120

 gagcccagag gagaagagcc gaggggcggt gcccgggcca gggggcggag gcaggcggct    180

 ctggctccct ctcgggacgc tctttccttc ttcctcttgt tcctcctcct gcctctcttc    240

 gcttcgcctg caaacgcggt gggggctgct cggcggtcag gagcagcaag agacagagcg    300

 acatgagaga ttggaccgcg ggctgcactg gagaatttac tggtaggata attcatccct    360

 aaagagattg aagtgagctt caga   atg gca aaa gag gag ccc cag agt atc     411
                              Met Ala Lys Glu Glu Pro Gln Ser Ile
                                1               5

 tca agg gac ttg cag gaa ctg cag aag aag ctg tct ctg ctg ata gac      459
 Ser Arg Asp Leu Gln Glu Leu Gln Lys Lys Leu Ser Leu Leu Ile Asp
  10                  15                  20                  25

 tcc ttc cag aat aac tca aag ctg ccc caa cac agc agg atc tca ctg      507
 Ser Phe Gln Asn Asn Ser Lys Leu Pro Gln His Ser Arg Ile Ser Leu
                  30                  35                  40

 gac tct gat gat gga gtg tcc agg ctg ggc agt gct ggc tcc aag gtg      555
 Asp Ser Asp Asp Gly Val Ser Arg Leu Gly Ser Ala Gly Ser Lys Val
              45                  50                  55

 gtg gcc ttt atg aag tct cca gtg ggt cag tac ttg gac agc cat ccg      603
 Val Ala Phe Met Lys Ser Pro Val Gly Gln Tyr Leu Asp Ser His Pro
          60                  65                  70

 ttt ctg gcc ttc acc ttg ctg gtg ttc att gtc atg tcg gcc gtt cct      651
 Phe Leu Ala Phe Thr Leu Leu Val Phe Ile Val Met Ser Ala Val Pro
      75                  80                  85

 gtt gga ttc ttc ctg ctc atc gtg gtg ctt acc acc ctg gct gct ctg      699
 Val Gly Phe Phe Leu Leu Ile Val Val Leu Thr Thr Leu Ala Ala Leu
  90                  95                 100                 105

 ctg ggg gtc ata ata ttg gaa gga ttg gtc atc tct gtg ggt ggc ttc      747
 Leu Gly Val Ile Ile Leu Glu Gly Leu Val Ile Ser Val Gly Gly Phe
                 110                 115                 120

 tca ctg ctc tgc atc ctc tgt ggt ttg ggc ttc gta tca ctc gcc atg      795
 Ser Leu Leu Cys Ile Leu Cys Gly Leu Gly Phe Val Ser Leu Ala Met
             125                 130                 135

 tcg ggg atg atg ata gca tct tat gta gtg gtc tcc agc ctc atc agc      843
 Ser Gly Met Met Ile Ala Ser Tyr Val Val Val Ser Ser Leu Ile Ser
         140                 145                 150

 tgc tgg ttt tct ccc agg cca ctg aca cag caa aac acc agt tgt gac      891
 Cys Trp Phe Ser Pro Arg Pro Leu Thr Gln Gln Asn Thr Ser Cys Asp
     155                 160                 165

 ttt ctg cca gcc atg aag tct gca gac ttc gag ggg ctt tac cag gaa      939
 Phe Leu Pro Ala Met Lys Ser Ala Asp Phe Glu Gly Leu Tyr Gln Glu
 170                 175                 180                 185

 tga gtga ctgctcagag gccggggctt cttttcaagt actgctggat catactcacc      996
 






      <210> 237
      <211> 3483
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (274)..(2097)

      <400> 237
 tcccgggtcg acgttttcgt cctccccagc ccttttgcgt acctcctcac catacacctg     60

 aaggaaggcc ggaacctggt tgtccgagat cgctgtggca caagtgatcc ttatgtgaaa    120

 tttaagctga atgggaagac gctgtacaaa agtaaagtca tatataagaa cttgaaccca    180

 gtatgggatg agatagttgt attgccaatc caaagccttg atcaaaagct acgtgtgaag    240

 gtatatgatc gagatttaac cacatctgat ttc atg ggt tct gca ttt gtc att     294
                                      Met Gly Ser Ala Phe Val Ile
                                        1               5

 ctc agt gat ctt gag ctt aac aga aca act gaa cat att tta aaa ctg      342
 Leu Ser Asp Leu Glu Leu Asn Arg Thr Thr Glu His Ile Leu Lys Leu
          10                  15                  20

 gaa gat cca aac agt tta gaa gat gac atg gga gtg atc gtc tta aat      390
 Glu Asp Pro Asn Ser Leu Glu Asp Asp Met Gly Val Ile Val Leu Asn
      25                  30                  35

 ttg aac cta gtg gta aaa cag ggt gat ttc aag aga cac cgt tgg tca      438
 Leu Asn Leu Val Val Lys Gln Gly Asp Phe Lys Arg His Arg Trp Ser
  40                  45                  50                  55

 aat cgg aag cga tta agt gcc agc aag tcc tct ttg ata cgc aac cta      486
 Asn Arg Lys Arg Leu Ser Ala Ser Lys Ser Ser Leu Ile Arg Asn Leu
                  60                  65                  70

 cgg ctc tct gag tcc ttg aaa aag aac caa ctc tgg aac ggg att ata      534
 Arg Leu Ser Glu Ser Leu Lys Lys Asn Gln Leu Trp Asn Gly Ile Ile
              75                  80                  85

 agt ata act ttg ttg gaa ggg aag aat gtc tca gga gga agc atg aca      582
 Ser Ile Thr Leu Leu Glu Gly Lys Asn Val Ser Gly Gly Ser Met Thr
          90                  95                 100

 gag atg ttt gtc cag tta aaa ctg gga gat cag agg tat aaa agt aag      630
 Glu Met Phe Val Gln Leu Lys Leu Gly Asp Gln Arg Tyr Lys Ser Lys
     105                 110                 115

 aca ctg tgt aag agt gca aat ccg cag tgg cag gaa cag ttt gac ttt      678
 Thr Leu Cys Lys Ser Ala Asn Pro Gln Trp Gln Glu Gln Phe Asp Phe
 120                 125                 130                 135

 cac tac ttc tct gac agg atg ggc att ttg gac att gaa gtg tgg gga      726
 His Tyr Phe Ser Asp Arg Met Gly Ile Leu Asp Ile Glu Val Trp Gly
                 140                 145                 150

 aag gac aac aaa aag cat gag gaa cgt ctg ggc acg tgt aaa gtg gat      774
 Lys Asp Asn Lys Lys His Glu Glu Arg Leu Gly Thr Cys Lys Val Asp
             155                 160                 165

 atc tcg gca ctc cct ctg aag caa gcc aac tgc ctg gag ctg cca ctg      822
 Ile Ser Ala Leu Pro Leu Lys Gln Ala Asn Cys Leu Glu Leu Pro Leu
         170                 175                 180

 gac agc tgt ctg ggg gct ctc ctt atg ttg gtc aca ctt aca ccc tgt      870
 Asp Ser Cys Leu Gly Ala Leu Leu Met Leu Val Thr Leu Thr Pro Cys
     185                 190                 195

 gcg ggg gtc tcc gtc tct gat ctg tgt gtc tgc ccc tta gca gac ctc      918
 Ala Gly Val Ser Val Ser Asp Leu Cys Val Cys Pro Leu Ala Asp Leu
 200                 205                 210                 215

 agc gaa aga aag cag att acc cag cga tat tgc tta cag aac tcc ctg      966
 Ser Glu Arg Lys Gln Ile Thr Gln Arg Tyr Cys Leu Gln Asn Ser Leu
                 220                 225                 230

 aaa gat gtg aaa gac gtc ggc att cta caa gtg aag gtt tta aag gca     1014
 Lys Asp Val Lys Asp Val Gly Ile Leu Gln Val Lys Val Leu Lys Ala
             235                 240                 245

 gca gat ctc tta gcg gca gat ttc tca ggg aag agt gac cca ttt tgc     1062
 Ala Asp Leu Leu Ala Ala Asp Phe Ser Gly Lys Ser Asp Pro Phe Cys
         250                 255                 260

 ttg ttg gag tta ggc aat gac cga ctt cag acg cat acc gtc tac aaa     1110
 Leu Leu Glu Leu Gly Asn Asp Arg Leu Gln Thr His Thr Val Tyr Lys
     265                 270                 275

 aac ctc aac cct gaa tgg aac aaa gtt ttt aca ttt ccc att aaa gat     1158
 Asn Leu Asn Pro Glu Trp Asn Lys Val Phe Thr Phe Pro Ile Lys Asp
 280                 285                 290                 295

 atc cat gat gtt ttg gaa gtg aca gtg ttt gat gaa gat gga gat aaa     1206
 Ile His Asp Val Leu Glu Val Thr Val Phe Asp Glu Asp Gly Asp Lys
                 300                 305                 310

 ccc cca gat ttt ctt gga aaa gtt gcc att ccc ttg ctg tcc att aga     1254
 Pro Pro Asp Phe Leu Gly Lys Val Ala Ile Pro Leu Leu Ser Ile Arg
             315                 320                 325

 gat gga caa ccg aat tgt tat gta cta aag aat aaa gat tta gaa caa     1302
 Asp Gly Gln Pro Asn Cys Tyr Val Leu Lys Asn Lys Asp Leu Glu Gln
         330                 335                 340

 gct ttt aaa gga gtt att tac tta gag atg gac ctt ata tat aat ccg     1350
 Ala Phe Lys Gly Val Ile Tyr Leu Glu Met Asp Leu Ile Tyr Asn Pro
     345                 350                 355

 gtg aaa gca agt att agg act ttt act ccc cgg gaa aag cgc ttt gtt     1398
 Val Lys Ala Ser Ile Arg Thr Phe Thr Pro Arg Glu Lys Arg Phe Val
 360                 365                 370                 375

 gaa gac agc cgc aag ctg tcc aaa aag atc tta tca aga gat gtg gac     1446
 Glu Asp Ser Arg Lys Leu Ser Lys Lys Ile Leu Ser Arg Asp Val Asp
                 380                 385                 390

 cgt gtg aaa aga atc act atg gca ata tgg aat aca atg cag ttc ctt     1494
 Arg Val Lys Arg Ile Thr Met Ala Ile Trp Asn Thr Met Gln Phe Leu
             395                 400                 405

 aaa agc tgc ttc cag tgg gaa tcc aca tta aga agt aca ata gca ttc     1542
 Lys Ser Cys Phe Gln Trp Glu Ser Thr Leu Arg Ser Thr Ile Ala Phe
         410                 415                 420

 gcg gta ttt ttg atc act gtc tgg aat ttt gaa cta tat atg atc ccc     1590
 Ala Val Phe Leu Ile Thr Val Trp Asn Phe Glu Leu Tyr Met Ile Pro
     425                 430                 435

 ttg gca ttg ttg ctg atc ttt gtc tac aat ttc atc aga cct gtg aaa     1638
 Leu Ala Leu Leu Leu Ile Phe Val Tyr Asn Phe Ile Arg Pro Val Lys
 440                 445                 450                 455

 ggc aag gtc agc agc atc cag gac agc cag gag agc aca gac ata gat     1686
 Gly Lys Val Ser Ser Ile Gln Asp Ser Gln Glu Ser Thr Asp Ile Asp
                 460                 465                 470

 gac gag gag gat gaa gat gac aag gaa tct gag aaa aag ggg ttg att     1734
 Asp Glu Glu Asp Glu Asp Asp Lys Glu Ser Glu Lys Lys Gly Leu Ile
             475                 480                 485

 gaa aga atc tat atg gta cag gat att gtt tca act gtt caa aac gtc     1782
 Glu Arg Ile Tyr Met Val Gln Asp Ile Val Ser Thr Val Gln Asn Val
         490                 495                 500

 ttg gag gaa ata gct tct ttt gga gaa agg att aag aac aca ttt aac     1830
 Leu Glu Glu Ile Ala Ser Phe Gly Glu Arg Ile Lys Asn Thr Phe Asn
     505                 510                 515

 tgg acg gtc ccc ttc ctt tca tct ctg gcc tgt ttg att ctg gca gca     1878
 Trp Thr Val Pro Phe Leu Ser Ser Leu Ala Cys Leu Ile Leu Ala Ala
 520                 525                 530                 535

 gcc acc atc att ttg tat ttc att cca ctg cgg tac atc att tta atc     1926
 Ala Thr Ile Ile Leu Tyr Phe Ile Pro Leu Arg Tyr Ile Ile Leu Ile
                 540                 545                 550

 tgg ggc ata aat aaa ttt act aag aag ctt cga aat ccc tat tcc atc     1974
 Trp Gly Ile Asn Lys Phe Thr Lys Lys Leu Arg Asn Pro Tyr Ser Ile
             555                 560                 565

 gac aat aat gag cta cta gac ttc ctc tct agg gta ccg tct gat gtt     2022
 Asp Asn Asn Glu Leu Leu Asp Phe Leu Ser Arg Val Pro Ser Asp Val
         570                 575                 580

 caa aag gtg cag tat gca gaa ttg aaa ctc tgc agc agc cac agc ccc     2070
 Gln Lys Val Gln Tyr Ala Glu Leu Lys Leu Cys Ser Ser His Ser Pro
     585                 590                 595

 ctg cgg aag aag cgc agc gct ctc tag ggcac acaccgactt tggacagcag     2122
 Leu Arg Lys Lys Arg Ser Ala Leu 
 600                 605

 cacccaatat tgtgtttggt tgagtagacc aatgttatgg ctgtttcagt ggtacccaag   2182

 gtgtccttct gaaatgcatg ccctgtggca ccctctgtat acttcctcct ccttcacgtg   2242

 cacagacata cacacatgtg cacacaccct catgcatggg tgtcctagtt gcgtagaggg   2302

 tcagcccagc gaaaagcaac aaccccaaga ctgtgaaaga ctaacatcca ttctgaaata   2362

 ggagataaca aggctgccat ggatctgaac accaccttcc ttgagaacag ccaggagccc   2422

 acttggattc aagagtgact ttgaacttgt tttcacacct ccaacagact ctcattaaga   2482

 ttcagttatt tccgctcccc agccccacac tcctttcaga ttatcgttca tgggcgtaag   2542

 tctcttctca gagttaacaa gtctttggta gtcatcctct gtccaaatat tgtatattat   2602

 taaaaggcat ttttaataat taccagaatt agctcaaacc tttagggatc tttcagccat   2662

 gattattaag gatatgtatg tgaatttttg ggaaacctct cggtgctgga tgccagccta   2722

 cagcagggtc cattgctggc aatggatggc ccaggaaggt ccctagagat cactcacttg   2782

 aaaaatgagg gtcccatgaa agtatttggt tgccttctga tgccacttct tctcacttta   2842

 ctttttgctt attttcaaaa tattataaaa tgtcaacata taatttcaga aaggcaggtg   2902

 ggggtagggg agaaatgaat gaataaattc tctaggtatt tagaaagata agaaactgaa   2962

 gaccgagaga ctaataaggc tgcttaccta attattataa tcatttcatt tgcctgaatg   3022

 ttttaagcag gaagtagaaa tactttggct gcccaaatgt atcttttgtt cctcttagaa   3082

 gtaaaataag ctacatacaa taaaaattta tttcagaacc ccatttctag aaaataccac   3142

 cccagagtcc tcatttgata gcatctgtct cctgcagacc tcatcattcc acagtatttc   3202

 cctgccatgt aaaaatcctg actttgtgcg tatataaaat gtatgcaatt aagtctgttt   3262

 aaatgatatt taagttttaa agactgtatt ttgttgacac atactttgtg cagtttttat   3322

 gtatgtatgt attataaaaa aagttaaggt taaaaagatc tcatttaata gtgagttcac   3382

 tatttttttt ttttgtctct gggttgtaat ttaataatct tcaaacaaaa tgtttacgaa   3442

 aaatgccaaa gattctaaat cttaaaaaaa aaaaaaaaaa g                       3483




      <210> 238
      <211> 3355
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (217)..(1671)

      <400> 238
 aaggatcctt aattttatta atcccccccc ccccgaaggc ccccagccgc ctgtgccccg     60

 cggtgcgcgc cccgctccgg gacctgccgc caccgccgcc ccgccctcgg cggcacccac    120

 acccaggcgc gcccgcgcgc gcgcccggcc ccgtccctgc ctggaagcac agctgaagat    180

 ggcgagcccg gcgcctccgg agcacgccga ggaggg  atg ccc ggc tcc tgc cgc     234
                                          Met Pro Gly Ser Cys Arg
                                            1               5

 cga gga gca ggc gcc gcc gtc gcc gcc acc gcc cca ggc atc ccc cgc      282
 Arg Gly Ala Gly Ala Ala Val Ala Ala Thr Ala Pro Gly Ile Pro Arg
              10                  15                  20

 aga gcg gca gca gca gga gga gga agc gca gga agc tgg ggc ggc gga      330
 Arg Ala Ala Ala Ala Gly Gly Gly Ser Ala Gly Ser Trp Gly Gly Gly
          25                  30                  35

 ggg cgc ggg gtt gca ggt gga gga ggc cgc ggg ccg ggc ggc ggc cgc      378
 Gly Arg Gly Val Ala Gly Gly Gly Gly Arg Gly Pro Gly Gly Gly Arg
      40                  45                  50

 gta acc tgg ctg ctc ggg gag ccg gtg ctg tgg ctg ggc tgc cgc gcc      426
 Val Thr Trp Leu Leu Gly Glu Pro Val Leu Trp Leu Gly Cys Arg Ala
  55                  60                  65                  70

 gac gag ctg ctg agc tgg aag agg ccg ctg cgg agc ctg ctc ggc ttc      474
 Asp Glu Leu Leu Ser Trp Lys Arg Pro Leu Arg Ser Leu Leu Gly Phe
                  75                  80                  85

 gtc gct gcc aac ctg ctg ttc tgg ttc ctt gca ttg act cca tgg aga      522
 Val Ala Ala Asn Leu Leu Phe Trp Phe Leu Ala Leu Thr Pro Trp Arg
              90                  95                 100

 gta tat cac ctg att tcc gtc atg ata ctt ggg cgt gtt att atg caa      570
 Val Tyr His Leu Ile Ser Val Met Ile Leu Gly Arg Val Ile Met Gln
         105                 110                 115

 ata ata aag gat atg gtt ttg tct aga aca aga ggt gca cag ttg tgg      618
 Ile Ile Lys Asp Met Val Leu Ser Arg Thr Arg Gly Ala Gln Leu Trp
     120                 125                 130

 aga agc ctc agt gaa agc tgg gaa gtt atc aat tcc aaa cca gat gaa      666
 Arg Ser Leu Ser Glu Ser Trp Glu Val Ile Asn Ser Lys Pro Asp Glu
 135                 140                 145                 150

 aga ccc agg ctc agc cac tgt att gca gaa tca tgg atg aat ttc agc      714
 Arg Pro Arg Leu Ser His Cys Ile Ala Glu Ser Trp Met Asn Phe Ser
                 155                 160                 165

 ata ttt ctt caa gaa atg tct ctt ttt aaa cag cag agc cct ggc aag      762
 Ile Phe Leu Gln Glu Met Ser Leu Phe Lys Gln Gln Ser Pro Gly Lys
             170                 175                 180

 ttt tgt ctc ctg gtc tgt agt gtg tgc aca ttt ttt acg atc ttg gga      810
 Phe Cys Leu Leu Val Cys Ser Val Cys Thr Phe Phe Thr Ile Leu Gly
         185                 190                 195

 agt tac att cct ggg gtt ata ctc agc tat cta ctg tta ctg tgt gca      858
 Ser Tyr Ile Pro Gly Val Ile Leu Ser Tyr Leu Leu Leu Leu Cys Ala
     200                 205                 210

 ttt ttg tgt cca ttg ttt aaa tgt aat gat att gga caa aaa att tac      906
 Phe Leu Cys Pro Leu Phe Lys Cys Asn Asp Ile Gly Gln Lys Ile Tyr
 215                 220                 225                 230

 agc aaa att aag tca gtt ctg ctg aaa ctg gat ttt gga att gga gaa      954
 Ser Lys Ile Lys Ser Val Leu Leu Lys Leu Asp Phe Gly Ile Gly Glu
                 235                 240                 245

 tat att aat cag aag aaa cgt gag aga tct gaa gca gat aaa gaa aaa     1002
 Tyr Ile Asn Gln Lys Lys Arg Glu Arg Ser Glu Ala Asp Lys Glu Lys
             250                 255                 260

 agt cac aaa gat gac agt gaa tta gac ttt tca gct ctt tgt cct aag     1050
 Ser His Lys Asp Asp Ser Glu Leu Asp Phe Ser Ala Leu Cys Pro Lys
         265                 270                 275

 att agc ctc acg gtt gct gcc aaa gag tta tct gtg tct gac aca gac     1098
 Ile Ser Leu Thr Val Ala Ala Lys Glu Leu Ser Val Ser Asp Thr Asp
     280                 285                 290

 gtc tca gag gta tcc tgg act gat aat ggg acc ttc aac ctt tca gaa     1146
 Val Ser Glu Val Ser Trp Thr Asp Asn Gly Thr Phe Asn Leu Ser Glu
 295                 300                 305                 310

 gga tac act cca cag aca gac act tct gat gat ctt gac cga ccc agt     1194
 Gly Tyr Thr Pro Gln Thr Asp Thr Ser Asp Asp Leu Asp Arg Pro Ser
                 315                 320                 325

 gag gaa gtt ttc tct aga gat ctt tca gat ttt cca tct cta gaa aat     1242
 Glu Glu Val Phe Ser Arg Asp Leu Ser Asp Phe Pro Ser Leu Glu Asn
             330                 335                 340

 ggc atg gga aca aat gat gaa gat gaa tta agc ctt ggt ttg ccc act     1290
 Gly Met Gly Thr Asn Asp Glu Asp Glu Leu Ser Leu Gly Leu Pro Thr
         345                 350                 355

 gag ctc aag aga aag aag gaa cag ttg gac agt ggt cac aga cca agc     1338
 Glu Leu Lys Arg Lys Lys Glu Gln Leu Asp Ser Gly His Arg Pro Ser
     360                 365                 370

 aaa gag acg caa tca gca gct ggt ctc acc ctt cct ctg aac agt gac     1386
 Lys Glu Thr Gln Ser Ala Ala Gly Leu Thr Leu Pro Leu Asn Ser Asp
 375                 380                 385                 390

 caa acc ttt cac ctg atg agc aac ctg gct ggg gat gtt atc aca gct     1434
 Gln Thr Phe His Leu Met Ser Asn Leu Ala Gly Asp Val Ile Thr Ala
                 395                 400                 405

 gca gtg act gca gct atc aaa gac cag tta gag ggt gtg cag caa gca     1482
 Ala Val Thr Ala Ala Ile Lys Asp Gln Leu Glu Gly Val Gln Gln Ala
             410                 415                 420

 ctt tct cag gct gcc ccc atc cca gaa gag gac aca gac act gaa gaa     1530
 Leu Ser Gln Ala Ala Pro Ile Pro Glu Glu Asp Thr Asp Thr Glu Glu
         425                 430                 435

 ggt gat gac ttt gaa cta ctt gac cag tca gag ctg gat caa att gag     1578
 Gly Asp Asp Phe Glu Leu Leu Asp Gln Ser Glu Leu Asp Gln Ile Glu
     440                 445                 450

 agt gaa ttg gga ctt aca caa gac cag gaa gca gaa gca cag caa aat     1626
 Ser Glu Leu Gly Leu Thr Gln Asp Gln Glu Ala Glu Ala Gln Gln Asn
 455                 460                 465                 470

 aag aag tct tca ggt ttc ctt tca aat ctg ctg gga ggc cat taa tct     1674
 Lys Lys Ser Ser Gly Phe Leu Ser Asn Leu Leu Gly Gly His 
                 475                 480

 aggaatcagc ttgcaacaga gcacaaaaaa caccaaaaaa atttcaaaca agaaaaaaaa   1734

 aaaaaaaagg aaaagaaaaa aattgaactg taagctttaa tgattacttt agatttgttt   1794

 tattttccct cctgcagtga attaattgga tatatatcag ctgacactga tagattgata   1854

 tttctgatcg ttatttttgt gtaataagca tggaaatgaa ctttatacac accactgtgt   1914

 tgtcagagat aaatattagg ggttgttttt aaagcaaaaa aaaaaaaaaa aaaaccaaac   1974

 tattaaaatc ctcctataaa tattcttttt ctttacagtt tttcaagcat gcaaaacagt   2034

 ttattgtaac ttactgaaaa atattaacaa ttaattgtga atacatgctg ttaccagctt   2094

 ccttattcct aatacctgga aaattttttt ttcaacggat agattttgat gtaaaaaaga   2154

 ccgaaattat caaggtatct tagttgaagg acttgggaaa tactatcaaa attaatttct   2214

 taggaaaaaa tttaaaagta tatttaagta ctctggatag actgaaacgt ttccatgtta   2274

 tttctgcagt tgtagactta ggcttatttg taaagaagca tgctccattg actgccatct   2334

 ctagtcttgc agtgggtggt attaacccat agaaagcaag cagttgtgta tcacatagac   2394

 aatggttatg atgtaaacag attcagttgt tttgttgttc attcgtcata tgtttgtgat   2454

 agggatgttg ggagcacagc tctattctgc ctgctcagac ttaagttaga cccttatctt   2514

 ttatattatg tcatgaaaaa agtctcctaa aattgtgaaa ctagttcttg atgagtgatg   2574

 tgatcatcag caataaagat ataataactc tgttttctta gcctgtatag aggagaggaa   2634

 cctgcttggc tttaaaatat atttatttgc catttaagta taaatatgga atctgtttct   2694

 tattgggaag atagaatata tatattttcc tttaaacttt ttaaggtcac ttttaaataa   2754

 ccaaatttga tttatggttt ttaacaaagg actaaagagc tgaaaccaac ctagttttgt   2814

 ttttgtgata taaactttaa gtgtcgaggg accatgccag caactaccaa aaatctctta   2874

 aatcttcagg tacagctggc attttggcag atgcatagag acatctgaga ccctcagaaa   2934

 ggaaggataa tccaagaata taggaaatct gtgttctctt cctttcattt tatcccttat   2994

 atttctaaag actaattata agtaatctga cattttaatg tagctactct tatttatttt   3054

 ttctttctga ggtattaaaa tatctggact gagttttgcc aaatgttaaa gggagaagag   3114

 ttactgaaga ctttgaacac ttgctttttg tgattgctta tgtcattagt gcctcatgac   3174

 tgtgtttgat gtcctttatt gatacaaagt gagcctgtgc cttcattatc ttgcccattt   3234

 taatacaaat ggaaacctgg tgtttgaaaa tctctgaact gtgtgggttt tggaggaata   3294

 tacctgaatt ttattcaata acagtttctg gacaggaaga aaaatacagt tacatattta   3354

 t                                                                   3355




      <210> 239
      <211> 3355
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (217)..(1671)

      <400> 239
 aaggatcctt aattttatta atcccccccc ccccgaaggc ccccagccgc ctgtgccccg     60

 cggtgcgcgc cccgctccgg gacctgccgc caccgccgcc ccgccctcgg cggcacccac    120

 acccaggcgc gcccgcgcgc gcgcccggcc ccgtccctgc ctggaagcac agctgaagat    180

 ggcgagcccg gcgcctccgg agcacgccga ggaggg  atg ccc ggc tcc tgc cgc     234
                                          Met Pro Gly Ser Cys Arg
                                            1               5

 cga gga gca ggc gcc gcc gtc gcc gcc acc gcc cca ggc atc ccc cgc      282
 Arg Gly Ala Gly Ala Ala Val Ala Ala Thr Ala Pro Gly Ile Pro Arg
              10                  15                  20

 aga gcg gca gca gca gga gga gga agc gca gga agc tgg ggc ggc gga      330
 Arg Ala Ala Ala Ala Gly Gly Gly Ser Ala Gly Ser Trp Gly Gly Gly
          25                  30                  35

 ggg cgc ggg gtt gca ggt gga gga ggc cgc ggg ccg ggc ggc ggc cgc      378
 Gly Arg Gly Val Ala Gly Gly Gly Gly Arg Gly Pro Gly Gly Gly Arg
      40                  45                  50

 ggt aac ctg gct gct cgg gga gcc ggt gct gtg gct ggg ctg ccg cgc      426
 Gly Asn Leu Ala Ala Arg Gly Ala Gly Ala Val Ala Gly Leu Pro Arg
  55                  60                  65                  70

 cga cga gct gct gag ctg gaa gag gcc gct gcg gag cct gct cgg ctt      474
 Arg Arg Ala Ala Glu Leu Glu Glu Ala Ala Ala Glu Pro Ala Arg Leu
                  75                  80                  85

 cgt cgc tgc caa cct gct gtt ctg gtc ctt gca ttg act cca tgg aga      522
 Arg Arg Cys Gln Pro Ala Val Leu Val Leu Ala Leu Thr Pro Trp Arg
              90                  95                 100

 gta tat cac ctg att tcc gtc atg ata ctt ggg cgt gtt att atg caa      570
 Val Tyr His Leu Ile Ser Val Met Ile Leu Gly Arg Val Ile Met Gln
         105                 110                 115

 ata ata aag gat atg gtt ttg tct aga aca aga ggt gca cag ttg tgg      618
 Ile Ile Lys Asp Met Val Leu Ser Arg Thr Arg Gly Ala Gln Leu Trp
     120                 125                 130

 aga agc ctc agt gaa agc tgg gaa gtt atc aat tcc aaa cca gat gaa      666
 Arg Ser Leu Ser Glu Ser Trp Glu Val Ile Asn Ser Lys Pro Asp Glu
 135                 140                 145                 150

 aga ccc agg ctc agc cac tgt att gca gaa tca tgg atg aat ttc agc      714
 Arg Pro Arg Leu Ser His Cys Ile Ala Glu Ser Trp Met Asn Phe Ser
                 155                 160                 165

 ata ttt ctt caa gaa atg tct ctt ttt aaa cag cag agc cct ggc aag      762
 Ile Phe Leu Gln Glu Met Ser Leu Phe Lys Gln Gln Ser Pro Gly Lys
             170                 175                 180

 ttt tgt ctc ctg gtc tgt agt gtg tgc aca ttt ttt acg atc ttg gga      810
 Phe Cys Leu Leu Val Cys Ser Val Cys Thr Phe Phe Thr Ile Leu Gly
         185                 190                 195

 agt tac att cct ggg gtt ata ctc agc tat cta ctg tta ctg tgt gca      858
 Ser Tyr Ile Pro Gly Val Ile Leu Ser Tyr Leu Leu Leu Leu Cys Ala
     200                 205                 210

 ttt ttg tgt cca ttg ttt aaa tgt aat gat att gga caa aaa att tac      906
 Phe Leu Cys Pro Leu Phe Lys Cys Asn Asp Ile Gly Gln Lys Ile Tyr
 215                 220                 225                 230

 agc aaa att aag tca gtt ctg ctg aaa ctg gat ttt gga att gga gaa      954
 Ser Lys Ile Lys Ser Val Leu Leu Lys Leu Asp Phe Gly Ile Gly Glu
                 235                 240                 245

 tat att aat cag aag aaa cgt gag aga tct gaa gca gat aaa gaa aaa     1002
 Tyr Ile Asn Gln Lys Lys Arg Glu Arg Ser Glu Ala Asp Lys Glu Lys
             250                 255                 260

 agt cac aaa gat gac agt gaa tta gac ttt tca gct ctt tgt cct aag     1050
 Ser His Lys Asp Asp Ser Glu Leu Asp Phe Ser Ala Leu Cys Pro Lys
         265                 270                 275

 att agc ctc acg gtt gct gcc aaa gag tta tct gtg tct gac aca gac     1098
 Ile Ser Leu Thr Val Ala Ala Lys Glu Leu Ser Val Ser Asp Thr Asp
     280                 285                 290

 gtc tca gag gta tcc tgg act gat aat ggg acc ttc aac ctt tca gaa     1146
 Val Ser Glu Val Ser Trp Thr Asp Asn Gly Thr Phe Asn Leu Ser Glu
 295                 300                 305                 310

 gga tac act cca cag aca gac act tct gat gat ctt gac cga ccc agt     1194
 Gly Tyr Thr Pro Gln Thr Asp Thr Ser Asp Asp Leu Asp Arg Pro Ser
                 315                 320                 325

 gag gaa gtt ttc tct aga gat ctt tca gat ttt cca tct cta gaa aat     1242
 Glu Glu Val Phe Ser Arg Asp Leu Ser Asp Phe Pro Ser Leu Glu Asn
             330                 335                 340

 ggc atg gga aca aat gat gaa gat gaa tta agc ctt ggt ttg ccc act     1290
 Gly Met Gly Thr Asn Asp Glu Asp Glu Leu Ser Leu Gly Leu Pro Thr
         345                 350                 355

 gag ctc aag aga aag aag gaa cag ttg gac agt ggt cac aga cca agc     1338
 Glu Leu Lys Arg Lys Lys Glu Gln Leu Asp Ser Gly His Arg Pro Ser
     360                 365                 370

 aaa gag acg caa tca gca gct ggt ctc acc ctt cct ctg aac agt gac     1386
 Lys Glu Thr Gln Ser Ala Ala Gly Leu Thr Leu Pro Leu Asn Ser Asp
 375                 380                 385                 390

 caa acc ttt cac ctg atg agc aac ctg gct ggg gat gtt atc aca gct     1434
 Gln Thr Phe His Leu Met Ser Asn Leu Ala Gly Asp Val Ile Thr Ala
                 395                 400                 405

 gca gtg act gca gct atc aaa gac cag tta gag ggt gtg cag caa gca     1482
 Ala Val Thr Ala Ala Ile Lys Asp Gln Leu Glu Gly Val Gln Gln Ala
             410                 415                 420

 ctt tct cag gct gcc ccc atc cca gaa gag gac aca gac act gaa gaa     1530
 Leu Ser Gln Ala Ala Pro Ile Pro Glu Glu Asp Thr Asp Thr Glu Glu
         425                 430                 435

 ggt gat gac ttt gaa cta ctt gac cag tca gag ctg gat caa att gag     1578
 Gly Asp Asp Phe Glu Leu Leu Asp Gln Ser Glu Leu Asp Gln Ile Glu
     440                 445                 450

 agt gaa ttg gga ctt aca caa gac cag gaa gca gaa gca cag caa aat     1626
 Ser Glu Leu Gly Leu Thr Gln Asp Gln Glu Ala Glu Ala Gln Gln Asn
 455                 460                 465                 470

 aag aag tct tca ggt ttc ctt tca aat ctg ctg gga ggc cat taa tct     1674
 Lys Lys Ser Ser Gly Phe Leu Ser Asn Leu Leu Gly Gly His 
                 475                 480

 aggaatcagc ttgcaacaga gcacaaaaaa caccaaaaaa atttcaaaca agaaaaaaaa   1734

 aaaaaaaagg aaaagaaaaa aattgaactg taagctttaa tgattacttt agatttgttt   1794

 tattttccct cctgcagtga attaattgga tatatatcag ctgacactga tagattgata   1854

 tttctgatcg ttatttttgt gtaataagca tggaaatgaa ctttatacac accactgtgt   1914

 tgtcagagat aaatattagg ggttgttttt aaagcaaaaa aaaaaaaaaa aaaaccaaac   1974

 tattaaaatc ctcctataaa tattcttttt ctttacagtt tttcaagcat gcaaaacagt   2034

 ttattgtaac ttactgaaaa atattaacaa ttaattgtga atacatgctg ttaccagctt   2094

 ccttattcct aatacctgga aaattttttt ttcaacggat agattttgat gtaaaaaaga   2154

 ccgaaattat caaggtatct tagttgaagg acttgggaaa tactatcaaa attaatttct   2214

 taggaaaaaa tttaaaagta tatttaagta ctctggatag actgaaacgt ttccatgtta   2274

 tttctgcagt tgtagactta ggcttatttg taaagaagca tgctccattg actgccatct   2334

 ctagtcttgc agtgggtggt attaacccat agaaagcaag cagttgtgta tcacatagac   2394

 aatggttatg atgtaaacag attcagttgt tttgttgttc attcgtcata tgtttgtgat   2454

 agggatgttg ggagcacagc tctattctgc ctgctcagac ttaagttaga cccttatctt   2514

 ttatattatg tcatgaaaaa agtctcctaa aattgtgaaa ctagttcttg atgagtgatg   2574

 tgatcatcag caataaagat ataataactc tgttttctta gcctgtatag aggagaggaa   2634

 cctgcttggc tttaaaatat atttatttgc catttaagta taaatatgga atctgtttct   2694

 tattgggaag atagaatata tatattttcc tttaaacttt ttaaggtcac ttttaaataa   2754

 ccaaatttga tttatggttt ttaacaaagg actaaagagc tgaaaccaac ctagttttgt   2814

 ttttgtgata taaactttaa gtgtcgaggg accatgccag caactaccaa aaatctctta   2874

 aatcttcagg tacagctggc attttggcag atgcatagag acatctgaga ccctcagaaa   2934

 ggaaggataa tccaagaata taggaaatct gtgttctctt cctttcattt tatcccttat   2994

 atttctaaag actaattata agtaatctga cattttaatg tagctactct tatttatttt   3054

 ttctttctga ggtattaaaa tatctggact gagttttgcc aaatgttaaa gggagaagag   3114

 ttactgaaga ctttgaacac ttgctttttg tgattgctta tgtcattagt gcctcatgac   3174

 tgtgtttgat gtcctttatt gatacaaagt gagcctgtgc cttcattatc ttgcccattt   3234

 taatacaaat ggaaacctgg tgtttgaaaa tctctgaact gtgtgggttt tggaggaata   3294

 tacctgaatt ttattcaata acagtttctg gacaggaaga aaaatacagt tacatattta   3354

 t                                                                   3355




      <210> 240
      <211> 651
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (128)..(502)

      <400> 240
 gcacgtggga aaggaggtct cactgagcac cgtcccagca tccggacacc acagcggccc     60

 ttcgctccac gcagaaaacc acacttctca aaccttcact caacacttcc ttccccaaag    120

 ccagaag  atg cac aag gag gaa cat ggg gtg gct gtg ctg ggg gca ccc     169
          Met His Lys Glu Glu His Gly Val Ala Val Leu Gly Ala Pro
            1               5                  10

 ccc agc acc atc ctt cca agg tcc acc gtg atc aac atc cac agc gag      217
 Pro Ser Thr Ile Leu Pro Arg Ser Thr Val Ile Asn Ile His Ser Glu
  15                  20                  25                  30

 acc tcc gtg ccc gac cat gtc gac tgg tcc ctg ttc aac acc ctc ttc      265
 Thr Ser Val Pro Asp His Val Asp Trp Ser Leu Phe Asn Thr Leu Phe
                  35                  40                  45

 ttg aac tgc tgc tgt ctg ggc ttc ata gca ttc gcc tac tcc gtg aag      313
 Leu Asn Cys Cys Cys Leu Gly Phe Ile Ala Phe Ala Tyr Ser Val Lys
              50                  55                  60

 tct agg gac agg aag atg gtt ggc gac gag acc gga gcc cag gcc tat      361
 Ser Arg Asp Arg Lys Met Val Gly Asp Glu Thr Gly Ala Gln Ala Tyr
          65                  70                  75

 gcc tac acc gac aag tgc ctg aac atc tgg gcc ctg aat ctg ggc ata      409
 Ala Tyr Thr Asp Lys Cys Leu Asn Ile Trp Ala Leu Asn Leu Gly Ile
      80                  85                  90

 ctc atg acc att gga ttc atc ctg tta ctg gta ttc gga tct gtg aca      457
 Leu Met Thr Ile Gly Phe Ile Leu Leu Leu Val Phe Gly Ser Val Thr
  95                 100                 105                 110

 gac tac cat att atg cta cag ata ata cag gaa ctg agt tac tag tag      505
 Asp Tyr His Ile Met Leu Gln Ile Ile Gln Glu Leu Ser Tyr 
                 115                 120

 ccgtccatag cctggaacct ttgcactcca ctgtgcaatg cttgacctgc acgctgaagc    565

 ttgtgcccct tgccacttgg tactgccact agatacagca gtgataccca cacacctgtt    625

 tacagggcac tcgtgcacgt gcttgt                                         651




      <210> 241
      <211> 1634
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (324)..(1634)

      <400> 241
 tgcaagacat ttcaggcaag aggaccactg tgacatatta ggagaatcgc gagaagaatg     60

 tgggtttgtg cagaagggtt tcaaagattc tagtgcatag taataagtaa atacatacaa    120

 gacagagtcc taaagaatgg atgaggaagg tgagccagaa ggattcctgt cactgaggaa    180

 tatgattgtc ttccccacac agagcctggg gacccactca gccaaatttc tccaacctcc    240

 ccaggcacca aaatgtgagt catcccggca ttcccctgcc accatctgtc acaaggtccc    300

 caaaggatgt ggagagagtc tcc    atg gac tct ggg aca gtg gaa agg gaa     350
                              Met Asp Ser Gly Thr Val Glu Arg Glu
                                1               5

 gga gga ggc agg aag aaa aca gaa aga gcc att ccc tca ggg gct aca      398
 Gly Gly Gly Arg Lys Lys Thr Glu Arg Ala Ile Pro Ser Gly Ala Thr
  10                  15                  20                  25

 aag act ata agt ccc cct gtt act acc tct gga cta ggg cat gtc cct      446
 Lys Thr Ile Ser Pro Pro Val Thr Thr Ser Gly Leu Gly His Val Pro
                  30                  35                  40

 gct acc tcc ccc tgc cag tct cat gcc aca ggc tgc act gaa gct gct      494
 Ala Thr Ser Pro Cys Gln Ser His Ala Thr Gly Cys Thr Glu Ala Ala
              45                  50                  55

 ctg ctg aaa gaa ctc ccc acc cac ctc cac tat tta gat gga gaa atg      542
 Leu Leu Lys Glu Leu Pro Thr His Leu His Tyr Leu Asp Gly Glu Met
          60                  65                  70

 gag agg cac tca aag cac ctc tgc tcc tca ctc ggt aaa gta cag gat      590
 Glu Arg His Ser Lys His Leu Cys Ser Ser Leu Gly Lys Val Gln Asp
      75                  80                  85

 gct ttc ttc tcc ctg gcc atg gcc ttg cca ttg ctc tta tct ccc tcc      638
 Ala Phe Phe Ser Leu Ala Met Ala Leu Pro Leu Leu Leu Ser Pro Ser
  90                  95                 100                 105

 tgc ttt gcc tct tct cag tct ctg tcc agt agg atg aac tca gag aac      686
 Cys Phe Ala Ser Ser Gln Ser Leu Ser Ser Arg Met Asn Ser Glu Asn
                 110                 115                 120

 ctc acc cgg gcc gcg gtt gcc cct gct gaa ttc gtc ctc ctg ggc atc      734
 Leu Thr Arg Ala Ala Val Ala Pro Ala Glu Phe Val Leu Leu Gly Ile
             125                 130                 135

 aca aat cgc tgg gac ctg cgt gtg gcc ctc ttc ctg acc tgc ctg cct      782
 Thr Asn Arg Trp Asp Leu Arg Val Ala Leu Phe Leu Thr Cys Leu Pro
         140                 145                 150

 gtc tac ctg gtg agc ctg ctg gga aac atg ggc atg gcg ctg ctg atc      830
 Val Tyr Leu Val Ser Leu Leu Gly Asn Met Gly Met Ala Leu Leu Ile
     155                 160                 165

 cgc atg gat gcc cgg ctc cac aca cct atg tac ttc ttc ctg gcc aac      878
 Arg Met Asp Ala Arg Leu His Thr Pro Met Tyr Phe Phe Leu Ala Asn
 170                 175                 180                 185

 ctc tcc ctg ctg gat gcc tgc tat tcc tcc gcc atc ggc ccc aag atg      926
 Leu Ser Leu Leu Asp Ala Cys Tyr Ser Ser Ala Ile Gly Pro Lys Met
                 190                 195                 200

 cta gtg gac ctg ctg ctg ccc cga gcc acc atc cct tac aca gcc tgt      974
 Leu Val Asp Leu Leu Leu Pro Arg Ala Thr Ile Pro Tyr Thr Ala Cys
             205                 210                 215

 gcc ctc cag atg ttt gtc ttt gca ggt ctg gct gat act gag tgt tgc     1022
 Ala Leu Gln Met Phe Val Phe Ala Gly Leu Ala Asp Thr Glu Cys Cys
         220                 225                 230

 ttg ctg gca gcc atg gcc tat gac cgc tac gtg gcc atc aga aac cca     1070
 Leu Leu Ala Ala Met Ala Tyr Asp Arg Tyr Val Ala Ile Arg Asn Pro
     235                 240                 245

 ctt ctc tat aca aca gct atg tcg cag cgt cta tgc ctg gcc ttg ctg     1118
 Leu Leu Tyr Thr Thr Ala Met Ser Gln Arg Leu Cys Leu Ala Leu Leu
 250                 255                 260                 265

 gga gca tca ggc ctg ggt ggg gca gtg agt gcc ttt gtt cac aca acc     1166
 Gly Ala Ser Gly Leu Gly Gly Ala Val Ser Ala Phe Val His Thr Thr
                 270                 275                 280

 ctc acc ttc cgc ctg agc ttc tgc cgc tcc cgg aag atc aat agc ttc     1214
 Leu Thr Phe Arg Leu Ser Phe Cys Arg Ser Arg Lys Ile Asn Ser Phe
             285                 290                 295

 ttc tgc gat atc cct cca ctg ctg gcc atc tcg tgc agt gac acc agt     1262
 Phe Cys Asp Ile Pro Pro Leu Leu Ala Ile Ser Cys Ser Asp Thr Ser
         300                 305                 310

 ctc aat gaa ctc ctt ctc ttc gcc atc tgt ggc ttc atc cag aca gcc     1310
 Leu Asn Glu Leu Leu Leu Phe Ala Ile Cys Gly Phe Ile Gln Thr Ala
     315                 320                 325

 acg gtg tta gct atc acg gtg tct tat ggc ttc atc gct ggg gct gtg     1358
 Thr Val Leu Ala Ile Thr Val Ser Tyr Gly Phe Ile Ala Gly Ala Val
 330                 335                 340                 345

 atc cac atg cgc tcg gtc gag ggc agt cgg cga gca gcc tcc acc ggt     1406
 Ile His Met Arg Ser Val Glu Gly Ser Arg Arg Ala Ala Ser Thr Gly
                 350                 355                 360

 ggt tcc cac ctc aca gcc gtg gcc atg atg tac ggg aca ctc att ttc     1454
 Gly Ser His Leu Thr Ala Val Ala Met Met Tyr Gly Thr Leu Ile Phe
             365                 370                 375

 atg tac ctg cgc ccc agc tcc agc tat gcc ctg gac act gac aag atg     1502
 Met Tyr Leu Arg Pro Ser Ser Ser Tyr Ala Leu Asp Thr Asp Lys Met
         380                 385                 390

 gcc tct gtg ttc tat acc ctg gtc atc ccg tct ctc aac cca ctc atc     1550
 Ala Ser Val Phe Tyr Thr Leu Val Ile Pro Ser Leu Asn Pro Leu Ile
     395                 400                 405

 tac agc ctc cgc aat aag gag gtc aag gag gcc ctc agg cag acc tgg     1598
 Tyr Ser Leu Arg Asn Lys Glu Val Lys Glu Ala Leu Arg Gln Thr Trp
 410                 415                 420                 425

 agc cga ttc cac tgt cca ggg cag ggg tcc cag tga                     1634
 Ser Arg Phe His Cys Pro Gly Gln Gly Ser Gln 
                 430                 435





      <210> 242
      <211> 3341
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (69)..(3341)

      <400> 242
 gacccgcggg gcgcgcggcc atcctgcggg cggcggcggc gggcgaggcg cctgcagccg     60

 ggcgcaag atg atg aag ttt cgg ttc cgg cgg cag ggc gcc gac ccg cag     110
          Met Met Lys Phe Arg Phe Arg Arg Gln Gly Ala Asp Pro Gln
            1               5                  10

 cgc gag aag ctc aag cag gag ctt ttc gcc ttc aac aag act gtg gag      158
 Arg Glu Lys Leu Lys Gln Glu Leu Phe Ala Phe Asn Lys Thr Val Glu
  15                  20                  25                  30

 cat ggc ttc ccc aat cag ccc agc gcc ctg gcc ttc gac ccg gaa ctt      206
 His Gly Phe Pro Asn Gln Pro Ser Ala Leu Ala Phe Asp Pro Glu Leu
                  35                  40                  45

 cgc atc atg gcc atc ggc acc agg tct ggg gct gtc aag atg tat cct      254
 Arg Ile Met Ala Ile Gly Thr Arg Ser Gly Ala Val Lys Met Tyr Pro
              50                  55                  60

 ttg cag gac agc tat ggt gca cct ggc gtg gag ttc aca ggc ctg cac      302
 Leu Gln Asp Ser Tyr Gly Ala Pro Gly Val Glu Phe Thr Gly Leu His
          65                  70                  75

 cgg gat gca gcc act gtc aca cag atg cac ttc ttg acc ggc cag ggc      350
 Arg Asp Ala Ala Thr Val Thr Gln Met His Phe Leu Thr Gly Gln Gly
      80                  85                  90

 cgc ctc ctg tcc ctg ctt gat gac agc agt ctg cat ctc tgg gag att      398
 Arg Leu Leu Ser Leu Leu Asp Asp Ser Ser Leu His Leu Trp Glu Ile
  95                 100                 105                 110

 gtc cac cat aat ggc tgt gcc cac ctg gaa gaa gca ctc agt ttc cag      446
 Val His His Asn Gly Cys Ala His Leu Glu Glu Ala Leu Ser Phe Gln
                 115                 120                 125

 ctg ccc agc cgg ccc ggc ttt gat ggt gcc agt gct ccg ctc agc ctt      494
 Leu Pro Ser Arg Pro Gly Phe Asp Gly Ala Ser Ala Pro Leu Ser Leu
             130                 135                 140

 acc cga gtc aca gtg gtc ctg ctg gtg gct gcc ggc gac ata gca gcc      542
 Thr Arg Val Thr Val Val Leu Leu Val Ala Ala Gly Asp Ile Ala Ala
         145                 150                 155

 ctg ggc act gag ggc agc agt gtc ttc ttc ctg gat gtt acc acc ctg      590
 Leu Gly Thr Glu Gly Ser Ser Val Phe Phe Leu Asp Val Thr Thr Leu
     160                 165                 170

 acc ctg ctc gag ggg cag acg ctt gcc cca ggc gag gtt ctg cgc agc      638
 Thr Leu Leu Glu Gly Gln Thr Leu Ala Pro Gly Glu Val Leu Arg Ser
 175                 180                 185                 190

 gtg cca gac gac tac cgc tgt ggg aag gca ctg ggc ccc gtg gag tca      686
 Val Pro Asp Asp Tyr Arg Cys Gly Lys Ala Leu Gly Pro Val Glu Ser
                 195                 200                 205

 ctc cag gga cac ctg cgg gac ccc aca aag att ctc att ggc tac agc      734
 Leu Gln Gly His Leu Arg Asp Pro Thr Lys Ile Leu Ile Gly Tyr Ser
             210                 215                 220

 cgg ggc ctg ctg gtc atc tgg aac cag gcc tcg cag tgt gtg gac cac      782
 Arg Gly Leu Leu Val Ile Trp Asn Gln Ala Ser Gln Cys Val Asp His
         225                 230                 235

 atc ttc ctg ggg aac cag cag ctg gag agc cta tgc tgg ggg cgt gat      830
 Ile Phe Leu Gly Asn Gln Gln Leu Glu Ser Leu Cys Trp Gly Arg Asp
     240                 245                 250

 agc agc act gtg gtc agc tca cac agc gat ggc agc tat gct gtc tgg      878
 Ser Ser Thr Val Val Ser Ser His Ser Asp Gly Ser Tyr Ala Val Trp
 255                 260                 265                 270

 tct gtg gat gcc ggc agc ttc cca acg ctg cag ccc acg gta gcc acc      926
 Ser Val Asp Ala Gly Ser Phe Pro Thr Leu Gln Pro Thr Val Ala Thr
                 275                 280                 285

 aca cct tac ggc ccc ttt ccc tgc aag gcc att aac aag att ctg tgg      974
 Thr Pro Tyr Gly Pro Phe Pro Cys Lys Ala Ile Asn Lys Ile Leu Trp
             290                 295                 300

 cgg aac tgt gaa tct ggg ggc cac ttt atc atc ttc agc ggt ggc atg     1022
 Arg Asn Cys Glu Ser Gly Gly His Phe Ile Ile Phe Ser Gly Gly Met
         305                 310                 315

 ccc cgt gcc agc tat ggt gac cgc cac tgt gta agt gtg ctt cga gcc     1070
 Pro Arg Ala Ser Tyr Gly Asp Arg His Cys Val Ser Val Leu Arg Ala
     320                 325                 330

 gag aca ttg gtg acg ctg gac ttc act tcc cgc atc atc gac ttc ttc     1118
 Glu Thr Leu Val Thr Leu Asp Phe Thr Ser Arg Ile Ile Asp Phe Phe
 335                 340                 345                 350

 aca gtg cac agc aca cgg ccc gag gat gaa ttt gat gac ccc cag gcc     1166
 Thr Val His Ser Thr Arg Pro Glu Asp Glu Phe Asp Asp Pro Gln Ala
                 355                 360                 365

 ctg gct gtg ctg ctg gaa gag gag ctg gtg gtg ctg gac ctg cag act     1214
 Leu Ala Val Leu Leu Glu Glu Glu Leu Val Val Leu Asp Leu Gln Thr
             370                 375                 380

 cct ggc tgg cca gct gtg cct gcc cca tac ctg gcc ccg ctg cac tcc     1262
 Pro Gly Trp Pro Ala Val Pro Ala Pro Tyr Leu Ala Pro Leu His Ser
         385                 390                 395

 tct gca atc act tgc tcg gcc cac gtg gcc agt gtc ccc gcc aag ctg     1310
 Ser Ala Ile Thr Cys Ser Ala His Val Ala Ser Val Pro Ala Lys Leu
     400                 405                 410

 tgg gcc cgc att gtg agc gct ggc gag cag cag agc ccc cag cct gtc     1358
 Trp Ala Arg Ile Val Ser Ala Gly Glu Gln Gln Ser Pro Gln Pro Val
 415                 420                 425                 430

 tcc agt gcc ttg agc tgg ccc atc act ggg ggc cga aac ctg gcc cag     1406
 Ser Ser Ala Leu Ser Trp Pro Ile Thr Gly Gly Arg Asn Leu Ala Gln
                 435                 440                 445

 gag ccg tca cag cga ggg ctg ctg ctg acg ggc cat gag gac ggc acc     1454
 Glu Pro Ser Gln Arg Gly Leu Leu Leu Thr Gly His Glu Asp Gly Thr
             450                 455                 460

 gtg agg ttc tgg gat gcc tcg ggt gtg gcg ctg cgg ccg ctc tat aag     1502
 Val Arg Phe Trp Asp Ala Ser Gly Val Ala Leu Arg Pro Leu Tyr Lys
         465                 470                 475

 ctg agc aca gct ggc ctc ttc cag aca gac tgt gag cac gct gac agc     1550
 Leu Ser Thr Ala Gly Leu Phe Gln Thr Asp Cys Glu His Ala Asp Ser
     480                 485                 490

 ctg gcc cag gct gcc gag gac gac tgg cca ccc ttc cgc aag gtg ggc     1598
 Leu Ala Gln Ala Ala Glu Asp Asp Trp Pro Pro Phe Arg Lys Val Gly
 495                 500                 505                 510

 tgc ttc gat ccc tac agt gac gat ccc cgg ctt ggc gtg cag aag gtt     1646
 Cys Phe Asp Pro Tyr Ser Asp Asp Pro Arg Leu Gly Val Gln Lys Val
                 515                 520                 525

 gct ctc tgc aag tat aca gcc cag atg gtg gtg gct ggc act gca ggc     1694
 Ala Leu Cys Lys Tyr Thr Ala Gln Met Val Val Ala Gly Thr Ala Gly
             530                 535                 540

 cag gtg ctg gta ctg gag ctt agt gat gtg ccg gtg gag cag gcg gtc     1742
 Gln Val Leu Val Leu Glu Leu Ser Asp Val Pro Val Glu Gln Ala Val
         545                 550                 555

 agc gtg gcc atc ata gac ctc ctc cag gac cgc gag ggc ttc aca tgg     1790
 Ser Val Ala Ile Ile Asp Leu Leu Gln Asp Arg Glu Gly Phe Thr Trp
     560                 565                 570

 aag ggc cac gag cgg ctg agc cca cgc acg ggg ccg ctg ccc tgg cct     1838
 Lys Gly His Glu Arg Leu Ser Pro Arg Thr Gly Pro Leu Pro Trp Pro
 575                 580                 585                 590

 gct ggc ttc cag ccc cgt gtc ctg gtg cag tgc ctg ccg cca gct gct     1886
 Ala Gly Phe Gln Pro Arg Val Leu Val Gln Cys Leu Pro Pro Ala Ala
                 595                 600                 605

 gta acc gct gtc aca ctc cac acc gag tgg agc ctc gtg gct ttt ggc     1934
 Val Thr Ala Val Thr Leu His Thr Glu Trp Ser Leu Val Ala Phe Gly
             610                 615                 620

 acc agt cat ggc ttt ggc ctc ttc gac tac cag cgc aag agc cct gtg     1982
 Thr Ser His Gly Phe Gly Leu Phe Asp Tyr Gln Arg Lys Ser Pro Val
         625                 630                 635

 ctg gcc agg tgc act ctt cac ccc aat gac tcc ctg gcc atg gag ggt     2030
 Leu Ala Arg Cys Thr Leu His Pro Asn Asp Ser Leu Ala Met Glu Gly
     640                 645                 650

 ccg ctc tcc cgg gtg aag tct ctc aag aag tca ctg cgc cag tct ttc     2078
 Pro Leu Ser Arg Val Lys Ser Leu Lys Lys Ser Leu Arg Gln Ser Phe
 655                 660                 665                 670

 cgg cgc att cgc aag agt cgt gtc tct ggc aag aag cgg gct gct aat     2126
 Arg Arg Ile Arg Lys Ser Arg Val Ser Gly Lys Lys Arg Ala Ala Asn
                 675                 680                 685

 gcc agc agc aag ttg cag gaa gcc aat gca cag ctg gct gag cag gcc     2174
 Ala Ser Ser Lys Leu Gln Glu Ala Asn Ala Gln Leu Ala Glu Gln Ala
             690                 695                 700

 tgc ccc cac gac gtg gag atg acg ccc gtg cag cgc cgc att gag ccc     2222
 Cys Pro His Asp Val Glu Met Thr Pro Val Gln Arg Arg Ile Glu Pro
         705                 710                 715

 cgc tct gcc gat gac tcc ttg tcg ggt gtc gtg cgt tgc cta tac ttt     2270
 Arg Ser Ala Asp Asp Ser Leu Ser Gly Val Val Arg Cys Leu Tyr Phe
     720                 725                 730

 gcc gac aca ttc ctt cga gat ggg gcc cac cac ggg ccc acc atg tgg     2318
 Ala Asp Thr Phe Leu Arg Asp Gly Ala His His Gly Pro Thr Met Trp
 735                 740                 745                 750

 gct ggc acc aac tca ggc tct gtg ttc gcc tat gca ctg gag gtg ccg     2366
 Ala Gly Thr Asn Ser Gly Ser Val Phe Ala Tyr Ala Leu Glu Val Pro
                 755                 760                 765

 gca gca gca gtg ggt ggt gag aag cgg cct gag caa gcg gtg gag gcc     2414
 Ala Ala Ala Val Gly Gly Glu Lys Arg Pro Glu Gln Ala Val Glu Ala
             770                 775                 780

 gtg ctg ggc aag gag gtg cag ctg atg cac cgg gcg cct gtg gtg gcc     2462
 Val Leu Gly Lys Glu Val Gln Leu Met His Arg Ala Pro Val Val Ala
         785                 790                 795

 att gcc gtg ttg gac ggg cgt ggc cgc cca ctg ccc gag ccc tac gag     2510
 Ile Ala Val Leu Asp Gly Arg Gly Arg Pro Leu Pro Glu Pro Tyr Glu
     800                 805                 810

 gcc tca cgg gac ctg gcg cag gca cct gac atg cag ggt ggt cac gct     2558
 Ala Ser Arg Asp Leu Ala Gln Ala Pro Asp Met Gln Gly Gly His Ala
 815                 820                 825                 830

 gtg ctc atc gca tct gag gag cag ttc aag gtg ttc aca ctg ccc aag     2606
 Val Leu Ile Ala Ser Glu Glu Gln Phe Lys Val Phe Thr Leu Pro Lys
                 835                 840                 845

 gtg agc gcg aag acc aag ttc aag ctg acg gcc cat gag ggc tgt cgt     2654
 Val Ser Ala Lys Thr Lys Phe Lys Leu Thr Ala His Glu Gly Cys Arg
             850                 855                 860

 gtg cgc aag gtg gca ctg gcc acg ttt gcc agt gtg gcc tgc gag gac     2702
 Val Arg Lys Val Ala Leu Ala Thr Phe Ala Ser Val Ala Cys Glu Asp
         865                 870                 875

 tat gct gag acc tgc ctg gcc tgc ctc acc aac ctg ggt gac gtc cac     2750
 Tyr Ala Glu Thr Cys Leu Ala Cys Leu Thr Asn Leu Gly Asp Val His
     880                 885                 890

 gtc ttc tcg gtg cct ggc ctg cgg ccc cag gtg cac tat tcc tgc atc     2798
 Val Phe Ser Val Pro Gly Leu Arg Pro Gln Val His Tyr Ser Cys Ile
 895                 900                 905                 910

 cgg aag gag gac atc agc ggc atc gct tcg tgc gtc ttt acg cgc cat     2846
 Arg Lys Glu Asp Ile Ser Gly Ile Ala Ser Cys Val Phe Thr Arg His
                 915                 920                 925

 ggc cag ggc ttt tac ctg ata tcc cca tca gaa ttt gaa cgc ttc tcc     2894
 Gly Gln Gly Phe Tyr Leu Ile Ser Pro Ser Glu Phe Glu Arg Phe Ser
             930                 935                 940

 cta agt gcc cgg aac atc aca gag ccg ctc tgc tct ctg gac att aac     2942
 Leu Ser Ala Arg Asn Ile Thr Glu Pro Leu Cys Ser Leu Asp Ile Asn
         945                 950                 955

 tgg ccc cgc gat gcc acc cag gcc agt tac agg atc cga gag tca ccc     2990
 Trp Pro Arg Asp Ala Thr Gln Ala Ser Tyr Arg Ile Arg Glu Ser Pro
     960                 965                 970

 aag ctg agc cag gct aac ggg acc cca agc atc ctg ctg gcc cca cag     3038
 Lys Leu Ser Gln Ala Asn Gly Thr Pro Ser Ile Leu Leu Ala Pro Gln
 975                 980                 985                 990

 agc ctt gat gga agc cct gat cca gcc cac agc atg gga cct ggc ccc     3086
 Ser Leu Asp Gly Ser Pro Asp Pro Ala His Ser Met Gly Pro Gly Pro
                 995                1000                1005

 cag gtg cag agg gtg cta agg gtc ctg gta ggg gct gat gac ttg ctc     3134
 Gln Val Gln Arg Val Leu Arg Val Leu Val Gly Ala Asp Asp Leu Leu
            1010                1015                1020

 cct gta gac acc ccg gag cca ccc gag gct gca ctc tca ccc atg tcc     3182
 Pro Val Asp Thr Pro Glu Pro Pro Glu Ala Ala Leu Ser Pro Met Ser
        1025                1030                1035

 atc gac tca gcc acc agt gct gac acc acg ctg gac acg aca ggg gac     3230
 Ile Asp Ser Ala Thr Ser Ala Asp Thr Thr Leu Asp Thr Thr Gly Asp
    1040                1045                1050

 gtc aca gtg gaa gat gtg aag gat ttc ctg ggc tcc tct gag gag tca     3278
 Val Thr Val Glu Asp Val Lys Asp Phe Leu Gly Ser Ser Glu Glu Ser
1055                1060                1065                1070

 gag aag aac ctg agg aac ctg gca gaa gac gag gcc cac gcc tgt gcc     3326
 Glu Lys Asn Leu Arg Asn Leu Ala Glu Asp Glu Ala His Ala Cys Ala
                1075                1080                1085

 atc ctg atc aaa tga                                                 3341
 Ile Leu Ile Lys 
            1090





      <210> 243
      <211> 718
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (35)..(718)

      <400> 243
 agaaagttac ctcttacaaa agcaacaggc ccat    atg gtt tta ctg agt att      52
                                          Met Val Leu Leu Ser Ile
                                            1               5

 cta caa acc gtc aaa gac cag cta agc tca tat ggt tat tgg cag gat      100
 Leu Gln Thr Val Lys Asp Gln Leu Ser Ser Tyr Gly Tyr Trp Gln Asp
              10                  15                  20

 tca gtt tct cat ggg gcg ttg gac aag ggc ctc agt tct tcg ctg act      148
 Ser Val Ser His Gly Ala Leu Asp Lys Gly Leu Ser Ser Ser Leu Thr
          25                  30                  35

 gtt gcc cac tct cag ttc ctt gaa atg tgc ctc ttc agt gtg gca gtg      196
 Val Ala His Ser Gln Phe Leu Glu Met Cys Leu Phe Ser Val Ala Val
      40                  45                  50

 ttc ttc atc gaa gca tgc aag cca caa ggc ccc agg gag agc cag caa      244
 Phe Phe Ile Glu Ala Cys Lys Pro Gln Gly Pro Arg Glu Ser Gln Gln
  55                  60                  65                  70

 gat ggc agt cac gct agt ctt caa agc ata aca cca gta gcc ttc aca      292
 Asp Gly Ser His Ala Ser Leu Gln Ser Ile Thr Pro Val Ala Phe Thr
                  75                  80                  85

 gcc agc ggc ctt gta ggt gaa gca agc tat tgg tac agg tcc aca ttg      340
 Ala Ser Gly Leu Val Gly Glu Ala Ser Tyr Trp Tyr Arg Ser Thr Leu
              90                  95                 100

 cct agt gct gtg gct gga agg agt cag ttt aat gcg agg caa acc acg      388
 Pro Ser Ala Val Ala Gly Arg Ser Gln Phe Asn Ala Arg Gln Thr Thr
         105                 110                 115

 ttt atc aac aca gag gtc aca aga tac ttt ata cag gag cat tcc cac      436
 Phe Ile Asn Thr Glu Val Thr Arg Tyr Phe Ile Gln Glu His Ser His
     120                 125                 130

 tgg cat cag gtc agt gcc cct ctg gga tgg agc tcc cag agg aag gag      484
 Trp His Gln Val Ser Ala Pro Leu Gly Trp Ser Ser Gln Arg Lys Glu
 135                 140                 145                 150

 caa gca gcc atc ttt gct gtt ctg cag cct gca ttg gtg atg cct cca      532
 Gln Ala Ala Ile Phe Ala Val Leu Gln Pro Ala Leu Val Met Pro Pro
                 155                 160                 165

 gca agg gca cag aac tgg gct gag gct gag atg gat gaa ctg aca gaa      580
 Ala Arg Ala Gln Asn Trp Ala Glu Ala Glu Met Asp Glu Leu Thr Glu
             170                 175                 180

 gta ggc ttc aga agg tgg gta ata acg aac ttc act gag cta aag gag      628
 Val Gly Phe Arg Arg Trp Val Ile Thr Asn Phe Thr Glu Leu Lys Glu
         185                 190                 195

 cat ctt cta acc caa tgc aaa gaa gct aag aac cct gat aaa aca tta      676
 His Leu Leu Thr Gln Cys Lys Glu Ala Lys Asn Pro Asp Lys Thr Leu
     200                 205                 210

 aac aag ctg tta acc aga ata agc agt tta gtg gga aca taa              718
 Asn Lys Leu Leu Thr Arg Ile Ser Ser Leu Val Gly Thr 
 215                 220                 225





      <210> 244
      <211> 1998
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (1)..(1998)

      <400> 244
  atg gcc ggc cac acg cag cag ccg agc ggg cgc ggg aac ccc agg cct      48
  Met Ala Gly His Thr Gln Gln Pro Ser Gly Arg Gly Asn Pro Arg Pro
    1               5                  10                  15

 gcg ccc tcg ccc tcc cca gtc cca ggg acc gtc ccc ggc gcc tcg gag       96
 Ala Pro Ser Pro Ser Pro Val Pro Gly Thr Val Pro Gly Ala Ser Glu
              20                  25                  30

 cgg gtg gcg ctc aag aag gag atc ggg ctg ctg agc gcc tgc acc atc      144
 Arg Val Ala Leu Lys Lys Glu Ile Gly Leu Leu Ser Ala Cys Thr Ile
          35                  40                  45

 atc atc ggc cac agg gag gct gcc tgg ctc ctt tct ccc cag aaa ggg      192
 Ile Ile Gly His Arg Glu Ala Ala Trp Leu Leu Ser Pro Gln Lys Gly
      50                  55                  60

 gcc ctg gtg gtg gtg gtg gtg gtg gtg gtg gtg gtg gtg gtg gtg gtg      240
 Ala Leu Val Val Val Val Val Val Val Val Val Val Val Val Val Val
  65                  70                  75                  80

 gtg atg gta gag gtg gtg gtg gtg gga gtg gag aag gcc aac tcc act      288
 Val Met Val Glu Val Val Val Val Gly Val Glu Lys Ala Asn Ser Thr
                  85                  90                  95

 atc acc ctc ctt ttc cag gac aga ctc tat gcc ctc ggt gtg ctc cag      336
 Ile Thr Leu Leu Phe Gln Asp Arg Leu Tyr Ala Leu Gly Val Leu Gln
             100                 105                 110

 gac ccc aag gga agc ccc aac tat aat ttc ggg gac ctg tca gtc ctg      384
 Asp Pro Lys Gly Ser Pro Asn Tyr Asn Phe Gly Asp Leu Ser Val Leu
         115                 120                 125

 ggc aca ctc atc cat tta ttc aac cac tac ata ctg aac ggt gtc agg      432
 Gly Thr Leu Ile His Leu Phe Asn His Tyr Ile Leu Asn Gly Val Arg
     130                 135                 140

 cac tgg ctt aca tgc cag aga cac cat ggg ggg gtc aag aca gac aaa      480
 His Trp Leu Thr Cys Gln Arg His His Gly Gly Val Lys Thr Asp Lys
 145                 150                 155                 160

 atc cat ctt ctg gtg tgg gag tcc cgc aac aag atg aac aag ctg aat      528
 Ile His Leu Leu Val Trp Glu Ser Arg Asn Lys Met Asn Lys Leu Asn
                 165                 170                 175

 gcc cta gtg cag atc tct ggt gaa gtt acc gga ttc atg tgc aca gat      576
 Ala Leu Val Gln Ile Ser Gly Glu Val Thr Gly Phe Met Cys Thr Asp
             180                 185                 190

 ggg aac atc atc ggc tcg ggc atc ttc atc tcg ccc aag ggg gtc ctg      624
 Gly Asn Ile Ile Gly Ser Gly Ile Phe Ile Ser Pro Lys Gly Val Leu
         195                 200                 205

 gag cac tca ggc tcc gtg ggt ctg gcc ctg ttc gtc tgg gtc ctg ggt      672
 Glu His Ser Gly Ser Val Gly Leu Ala Leu Phe Val Trp Val Leu Gly
     210                 215                 220

 ggg ggc gtg acg gct ctg ggc tcc ctc tgc tat gca gag ctg gga gtc      720
 Gly Gly Val Thr Ala Leu Gly Ser Leu Cys Tyr Ala Glu Leu Gly Val
 225                 230                 235                 240

 gcc atc ccc aag tct ggc ggg gac tac gcc tac gtc aca gag atc ttc      768
 Ala Ile Pro Lys Ser Gly Gly Asp Tyr Ala Tyr Val Thr Glu Ile Phe
                 245                 250                 255

 ggg ggc ctg gct ggc ttt ctg ctg ctc tgg agc gcc gtc ctc atc atg      816
 Gly Gly Leu Ala Gly Phe Leu Leu Leu Trp Ser Ala Val Leu Ile Met
             260                 265                 270

 tac ccc acc agc ctt gct gtc atc tcc atg acc ttc tcc aac tac gtg      864
 Tyr Pro Thr Ser Leu Ala Val Ile Ser Met Thr Phe Ser Asn Tyr Val
         275                 280                 285

 ctg cag ccc gtg ttc ccc aac tgc atc ccc ccc acc aca gcc tcc cgg      912
 Leu Gln Pro Val Phe Pro Asn Cys Ile Pro Pro Thr Thr Ala Ser Arg
     290                 295                 300

 gtg ctg tcc atg gcc tgc ctg atg ctc ctg aca tgg gtg aac agc tcc      960
 Val Leu Ser Met Ala Cys Leu Met Leu Leu Thr Trp Val Asn Ser Ser
 305                 310                 315                 320

 agt gtg cgc tgg gcc acg cgc atc cag gac atg ttc aca ggc ggg aag     1008
 Ser Val Arg Trp Ala Thr Arg Ile Gln Asp Met Phe Thr Gly Gly Lys
                 325                 330                 335

 ctg ctg gcc ttg tcc ctc atc atc ggc gtg ggc ctt ctc cag atc ttc     1056
 Leu Leu Ala Leu Ser Leu Ile Ile Gly Val Gly Leu Leu Gln Ile Phe
             340                 345                 350

 caa gga cac ttc gag gag ctg agg ccc agc aat gcc ttt gct ttc tgg     1104
 Gln Gly His Phe Glu Glu Leu Arg Pro Ser Asn Ala Phe Ala Phe Trp
         355                 360                 365

 atg acg ccc tcc gtg gga cac ctg gcc ctg gcc ttc ctc cag ggc tcc     1152
 Met Thr Pro Ser Val Gly His Leu Ala Leu Ala Phe Leu Gln Gly Ser
     370                 375                 380

 ttc gcc ttc agt ggc tgg aac ttc ctc aac tat gtc acc gag gag atg     1200
 Phe Ala Phe Ser Gly Trp Asn Phe Leu Asn Tyr Val Thr Glu Glu Met
 385                 390                 395                 400

 gtt gac gcc cga aag aac cta cct cgc gcc atc ttc atc tcc atc cca     1248
 Val Asp Ala Arg Lys Asn Leu Pro Arg Ala Ile Phe Ile Ser Ile Pro
                 405                 410                 415

 ctg gtg acc ttc gtg tac acg ttc acc aac att gcc tac ttc acg gcc     1296
 Leu Val Thr Phe Val Tyr Thr Phe Thr Asn Ile Ala Tyr Phe Thr Ala
             420                 425                 430

 atg tcc ccc cag gag ctg ctc tcc tcc aat gcg gtg gct gtg acc ttc     1344
 Met Ser Pro Gln Glu Leu Leu Ser Ser Asn Ala Val Ala Val Thr Phe
         435                 440                 445

 ggg gag aag ctg ctg ggc tac ttt tct tgg gtc atg cct gtc tcc gtg     1392
 Gly Glu Lys Leu Leu Gly Tyr Phe Ser Trp Val Met Pro Val Ser Val
     450                 455                 460

 gct ctg tca acc ttc gga ggg atc aat ggt tac ctg ttc acc tac tcc     1440
 Ala Leu Ser Thr Phe Gly Gly Ile Asn Gly Tyr Leu Phe Thr Tyr Ser
 465                 470                 475                 480

 agg ctg tgc ttc tct gga gcc cgc gag ggg cac ctg ccc agc ctg ctg     1488
 Arg Leu Cys Phe Ser Gly Ala Arg Glu Gly His Leu Pro Ser Leu Leu
                 485                 490                 495

 gcc atg atc cac gtc aga cac tgc acc ccc atc ccc gcc ctc ctc gtc     1536
 Ala Met Ile His Val Arg His Cys Thr Pro Ile Pro Ala Leu Leu Val
             500                 505                 510

 tgt tgc ggg gcc aca gcc gtc atc atg ctc gtg ggc gac acg tac acg     1584
 Cys Cys Gly Ala Thr Ala Val Ile Met Leu Val Gly Asp Thr Tyr Thr
         515                 520                 525

 ctc atc aac tat gtg tcc ttc atc aac tac ctc tgc tac ggc gtc acc     1632
 Leu Ile Asn Tyr Val Ser Phe Ile Asn Tyr Leu Cys Tyr Gly Val Thr
     530                 535                 540

 atc ctg ggc ctg ctg ctg ctg cgc tgg agg cgg cct gca ctc cac agg     1680
 Ile Leu Gly Leu Leu Leu Leu Arg Trp Arg Arg Pro Ala Leu His Arg
 545                 550                 555                 560

 ccc atc aag gtg aac ctt ctc atc ccc gtg gcg tac ttg gtc ttc tgg     1728
 Pro Ile Lys Val Asn Leu Leu Ile Pro Val Ala Tyr Leu Val Phe Trp
                 565                 570                 575

 gcc ttc ctg ctg gtc ttc agc ttc atc tca gag cct atg gtc tgt ggg     1776
 Ala Phe Leu Leu Val Phe Ser Phe Ile Ser Glu Pro Met Val Cys Gly
             580                 585                 590

 gtc ggc gtc atc atc atc ctt acg ggg gtg ccc att ttc ttt ctg gga     1824
 Val Gly Val Ile Ile Ile Leu Thr Gly Val Pro Ile Phe Phe Leu Gly
         595                 600                 605

 gtg ttc tgg aga agc aaa cca aag tgt gtg cac aga ctc aca gag tcc     1872
 Val Phe Trp Arg Ser Lys Pro Lys Cys Val His Arg Leu Thr Glu Ser
     610                 615                 620

 atg aca cac tgg ggc cag gag ctg tgt ttc gtg gtc tac ccc cag gac     1920
 Met Thr His Trp Gly Gln Glu Leu Cys Phe Val Val Tyr Pro Gln Asp
 625                 630                 635                 640

 gcc ccc gaa gag gag gag aat ggc ccc tgc cca ccc tcc ctg ctg cct     1968
 Ala Pro Glu Glu Glu Glu Asn Gly Pro Cys Pro Pro Ser Leu Leu Pro
                 645                 650                 655

 gcc aca gac aag ccc tcg aag cca caa tga                             1998
 Ala Thr Asp Lys Pro Ser Lys Pro Gln 
             660                 665





      <210> 245
      <211> 1534
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (133)..(1512)

      <400> 245
 ggcttttaga tgggtctgga gcttggagga gaagtctgaa ctaaggataa actaaagaga     60

 ggccaatgag acttgaaccc tgagcctaag ttgtcaccag caggactgat gtgcacacag    120

 aaggaatgaa gt    atg gat gtg aaa gaa cgc agg cct tac tgc tcc ctg     168
                  Met Asp Val Lys Glu Arg Arg Pro Tyr Cys Ser Leu
                    1               5                  10

 acc aag agc aga cga gag aag gaa cgg cgc tac aca aat tcc tcc gca      216
 Thr Lys Ser Arg Arg Glu Lys Glu Arg Arg Tyr Thr Asn Ser Ser Ala
          15                  20                  25

 gac aat gag gag tgc cgg gta ccc aca cag aag tcc tac agt tcc agc      264
 Asp Asn Glu Glu Cys Arg Val Pro Thr Gln Lys Ser Tyr Ser Ser Ser
      30                  35                  40

 gag aca ttg aaa gct ttt gat cat gat tcc tcg cgg ctg ctt tac ggc      312
 Glu Thr Leu Lys Ala Phe Asp His Asp Ser Ser Arg Leu Leu Tyr Gly
  45                  50                  55                  60

 aac aga gtg aag gat ttg gtt cac aga gaa gca gac gag ttc act aga      360
 Asn Arg Val Lys Asp Leu Val His Arg Glu Ala Asp Glu Phe Thr Arg
                  65                  70                  75

 caa gga cag aat ttt acc cta agg cag tta gga gtt tgt gaa cca gca      408
 Gln Gly Gln Asn Phe Thr Leu Arg Gln Leu Gly Val Cys Glu Pro Ala
              80                  85                  90

 act cga aga gga ctg gca ttt tgt gcg gaa atg ggg ctc cct cac aga      456
 Thr Arg Arg Gly Leu Ala Phe Cys Ala Glu Met Gly Leu Pro His Arg
          95                 100                 105

 ggt tac tct atc agt gca ggg tca gat gct gat act gaa aat gaa gca      504
 Gly Tyr Ser Ile Ser Ala Gly Ser Asp Ala Asp Thr Glu Asn Glu Ala
     110                 115                 120

 gtg atg tcc cca gag cat gcc atg aga ctt tgg ggc agg ggg gtc aaa      552
 Val Met Ser Pro Glu His Ala Met Arg Leu Trp Gly Arg Gly Val Lys
 125                 130                 135                 140

 tca ggc cgc agc tcc tgc ctg tca agt cgg tcc aac tca gcc ctc acc      600
 Ser Gly Arg Ser Ser Cys Leu Ser Ser Arg Ser Asn Ser Ala Leu Thr
                 145                 150                 155

 ctg aca gat acg gag cac gaa aac aag tcc gac agt gag aat gag caa      648
 Leu Thr Asp Thr Glu His Glu Asn Lys Ser Asp Ser Glu Asn Glu Gln
             160                 165                 170

 cct gca agc aat caa ggc cag tct acc ctg cag ccc ttg ccg cct tcc      696
 Pro Ala Ser Asn Gln Gly Gln Ser Thr Leu Gln Pro Leu Pro Pro Ser
         175                 180                 185

 cat aag cag cac tct gca cag cat cat cca tcc atc act tct ctc aac      744
 His Lys Gln His Ser Ala Gln His His Pro Ser Ile Thr Ser Leu Asn
     190                 195                 200

 aga aac tcc ctg acc aat aga agg aac cag agt ccg gcc ccg ccg gct      792
 Arg Asn Ser Leu Thr Asn Arg Arg Asn Gln Ser Pro Ala Pro Pro Ala
 205                 210                 215                 220

 gct ttg ccc gcc gag ctg caa acc aca ccc gag tcc gtc cag ctg cag      840
 Ala Leu Pro Ala Glu Leu Gln Thr Thr Pro Glu Ser Val Gln Leu Gln
                 225                 230                 235

 gac agc tgg gtc ctt ggc agt aat gta cca ctg gaa agc agg cat ttc      888
 Asp Ser Trp Val Leu Gly Ser Asn Val Pro Leu Glu Ser Arg His Phe
             240                 245                 250

 cta ttc aaa aca gga aca ggt aca acg cca ctg ttc agt act gca acc      936
 Leu Phe Lys Thr Gly Thr Gly Thr Thr Pro Leu Phe Ser Thr Ala Thr
         255                 260                 265

 cca gga tac aca atg gca tct ggc tct gtt tat tca cca cct act cgg      984
 Pro Gly Tyr Thr Met Ala Ser Gly Ser Val Tyr Ser Pro Pro Thr Arg
     270                 275                 280

 cca cta cct aga aac acc cta tca aga agt gct ttt aaa ttc aag aag     1032
 Pro Leu Pro Arg Asn Thr Leu Ser Arg Ser Ala Phe Lys Phe Lys Lys
 285                 290                 295                 300

 tct tca aag tac tgt agc tgg aaa tgc act gca ctg tgt gcc gta ggg     1080
 Ser Ser Lys Tyr Cys Ser Trp Lys Cys Thr Ala Leu Cys Ala Val Gly
                 305                 310                 315

 gtc tcg gtg ctc ctg gca ata ctc ctg tct tat ttt ata gca atg cat     1128
 Val Ser Val Leu Leu Ala Ile Leu Leu Ser Tyr Phe Ile Ala Met His
             320                 325                 330

 ctc ttt ggc ctc aac tgg cag cta cag cag act gaa aat gac aca ttt     1176
 Leu Phe Gly Leu Asn Trp Gln Leu Gln Gln Thr Glu Asn Asp Thr Phe
         335                 340                 345

 gag aat gga aaa gtg aat tct gat acc atg cca aca aac act gtg tca     1224
 Glu Asn Gly Lys Val Asn Ser Asp Thr Met Pro Thr Asn Thr Val Ser
     350                 355                 360

 tta cct tct gga gac aat gga aaa tta ggt gga ttt acg caa gaa aat     1272
 Leu Pro Ser Gly Asp Asn Gly Lys Leu Gly Gly Phe Thr Gln Glu Asn
 365                 370                 375                 380

 aac acc ata gat tcc gga gaa ctt gat att ggc cga aga gca att caa     1320
 Asn Thr Ile Asp Ser Gly Glu Leu Asp Ile Gly Arg Arg Ala Ile Gln
                 385                 390                 395

 gag att cct ccc ggg atc ttc tgg aga tca cag ctc ttc att gat cag     1368
 Glu Ile Pro Pro Gly Ile Phe Trp Arg Ser Gln Leu Phe Ile Asp Gln
             400                 405                 410

 cca cag ttt ctt aaa ttc aat atc tct ctt cag aag gat gca ttg att     1416
 Pro Gln Phe Leu Lys Phe Asn Ile Ser Leu Gln Lys Asp Ala Leu Ile
         415                 420                 425

 gga gta tat ggc cgg aag aag tta ccg cct tcc cat act cag gta aga     1464
 Gly Val Tyr Gly Arg Lys Lys Leu Pro Pro Ser His Thr Gln Val Arg
     430                 435                 440

 cta ggc ttt ctt atc aat aaa ata aaa act gcc agt tgc att ttt tga     1512
 Leu Gly Phe Leu Ile Asn Lys Ile Lys Thr Ala Ser Cys Ile Phe 
 445                 450                 455

 aattaaaaaa aaaaaaaaaa aa                                            1534




      <210> 246
      <211> 643
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (8)..(463)

      <400> 246
 cgcaaac  atg gca gcg cag aag gac cag cag aga gat gcc gag gcg gaa      49
          Met Ala Ala Gln Lys Asp Gln Gln Arg Asp Ala Glu Ala Glu
            1               5                  10

 ggg ctg agc ggc acg acc ctg ctg ccg aag ctg att ccc tcc ggt gca       97
 Gly Leu Ser Gly Thr Thr Leu Leu Pro Lys Leu Ile Pro Ser Gly Ala
  15                  20                  25                  30

 ggc cgg gag tgg ctg gag cgg cgc cgc gcg acc atc cgg ccc tgg agc      145
 Gly Arg Glu Trp Leu Glu Arg Arg Arg Ala Thr Ile Arg Pro Trp Ser
                  35                  40                  45

 acc ttc gtg gac cag cag cgc ttc tca cgg ccc cgc aac ctg gga gag      193
 Thr Phe Val Asp Gln Gln Arg Phe Ser Arg Pro Arg Asn Leu Gly Glu
              50                  55                  60

 ctg tgc cag cgc ctc gta cgc aac gtg gag tac tac cag agc aac tat      241
 Leu Cys Gln Arg Leu Val Arg Asn Val Glu Tyr Tyr Gln Ser Asn Tyr
          65                  70                  75

 gtg ttc gtg ttc ctg ggc ctc atc ctg tac tgt gtg gtg acg tcc cct      289
 Val Phe Val Phe Leu Gly Leu Ile Leu Tyr Cys Val Val Thr Ser Pro
      80                  85                  90

 atg ttg ctg gtg gct ctg gct gtc ttt ttc ggc gcc tgt tac att ctc      337
 Met Leu Leu Val Ala Leu Ala Val Phe Phe Gly Ala Cys Tyr Ile Leu
  95                 100                 105                 110

 tat ctg cgc acc ttg gag tcc aag ctt gtg ctc ttt gga gcc acc ctg      385
 Tyr Leu Arg Thr Leu Glu Ser Lys Leu Val Leu Phe Gly Ala Thr Leu
                 115                 120                 125

 gtg gtc atc ggc tcc cac gct gcc ttc cac cag att gag gct gtg gac      433
 Val Val Ile Gly Ser His Ala Ala Phe His Gln Ile Glu Ala Val Asp
             130                 135                 140

 ggg gag gag ctg cag atg gaa ccc gtg tga g gtgtcttctg ggacctgccg      484
 Gly Glu Glu Leu Gln Met Glu Pro Val 
         145                 150

 gcctcccggg ccagctgccc cacccctgcc catgcctgtc ctgcacggct ctgctgctcg    544

 ggcccacagc gccgtcccat cacaagcccg gggagggatc ccgcctttga aaataaagct    604

 gttatgggtg tcattcagaa aaaaaaaaaa aaaaacatg                           643




      <210> 247
      <211> 1392
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (400)..(1392)

      <400> 247
 atgcaccggg ccggcgggca ggcgggcgaa ctcgcggggc cgcttctgcg tgtgcacctg     60

 gccgccgccc gggagcctgc cacgggccgg gaatggccgc tgctccgccc tctgagaggt    120

 gctccaggct ccctggggac ggaggtttac acgtccccgt gccgcgctcc cagatctggg    180

 cgtaagtgtg gacctttgtg taccagagag aacatcatgg tggctttcaa aggggtctgg    240

 actcaagctt tctggaaagc agtcacagcg gaatttctgg ccatgcttat ttttgttctc    300

 ctcagcctgg gatccaccat caactggggt ggaacagaaa agcctttacc ggtcgacatg    360

 gttctcatct ccctttgctt tggactcagc attgcaacc   atg gtg cag tgc ttt     414
                                              Met Val Gln Cys Phe
                                                1               5

 ggc cat atc agc ggt ggc cac atc aac cct gca gtg act gtg gcc atg      462
 Gly His Ile Ser Gly Gly His Ile Asn Pro Ala Val Thr Val Ala Met
                  10                  15                  20

 gtg tgc acc agg aag atc agc atc gcc aag tct gtc ttc tac atc gca      510
 Val Cys Thr Arg Lys Ile Ser Ile Ala Lys Ser Val Phe Tyr Ile Ala
              25                  30                  35

 gcc cag tgc ctg ggg gcc atc att gga gca gga atc ctc tat ctg gtc      558
 Ala Gln Cys Leu Gly Ala Ile Ile Gly Ala Gly Ile Leu Tyr Leu Val
          40                  45                  50

 aca cct ccc act ggt agt gcc aca gta gat tta tgc tgc aca aaa gct      606
 Thr Pro Pro Thr Gly Ser Ala Thr Val Asp Leu Cys Cys Thr Lys Ala
      55                  60                  65

 gtg agc ctt ctg cct ggg gaa ccc ccg caa aag gtc cca aca gga gtc      654
 Val Ser Leu Leu Pro Gly Glu Pro Pro Gln Lys Val Pro Thr Gly Val
  70                  75                  80                  85

 tgt gga ccc ttg cca gca ggg aca aca gga tta ctt tta gga aag tct      702
 Cys Gly Pro Leu Pro Ala Gly Thr Thr Gly Leu Leu Leu Gly Lys Ser
                  90                  95                 100

 agt tta ggt tta aaa ggg gta caa ata cat aca gga gtc att gat tca      750
 Ser Leu Gly Leu Lys Gly Val Gln Ile His Thr Gly Val Ile Asp Ser
             105                 110                 115

 gat tat aat gga gaa att caa att gtt gta tct act tct gtt ccc tgg      798
 Asp Tyr Asn Gly Glu Ile Gln Ile Val Val Ser Thr Ser Val Pro Trp
         120                 125                 130

 aaa gca gag cca gga gaa cac ata gca cag ttc ctg att gtg cca ttt      846
 Lys Ala Glu Pro Gly Glu His Ile Ala Gln Phe Leu Ile Val Pro Phe
     135                 140                 145

 gtg gaa atg gga aaa agt gaa att aaa cga aca gga gga ttt gga agc      894
 Val Glu Met Gly Lys Ser Glu Ile Lys Arg Thr Gly Gly Phe Gly Ser
 150                 155                 160                 165

 aca aat aaa caa ggc aaa gca gct tat tgg gta aat caa att act gat      942
 Thr Asn Lys Gln Gly Lys Ala Ala Tyr Trp Val Asn Gln Ile Thr Asp
                 170                 175                 180

 aaa cat cct acc tgt gaa ata act att cag gga aag aaa tgt aaa ggt      990
 Lys His Pro Thr Cys Glu Ile Thr Ile Gln Gly Lys Lys Cys Lys Gly
             185                 190                 195

 ttg gta gat aca gga gca gac att tca atc att tct cta cag cac tgg     1038
 Leu Val Asp Thr Gly Ala Asp Ile Ser Ile Ile Ser Leu Gln His Trp
         200                 205                 210

 ctg tcc gtg tgg cca att caa cct gca caa ttt aac ata gtt gga gtt     1086
 Leu Ser Val Trp Pro Ile Gln Pro Ala Gln Phe Asn Ile Val Gly Val
     215                 220                 225

 ggt aaa gcc cct gaa gta tat caa agt agt tat att ttg cat cgt gaa     1134
 Gly Lys Ala Pro Glu Val Tyr Gln Ser Ser Tyr Ile Leu His Arg Glu
 230                 235                 240                 245

 ggg cct gat gga caa cct ggg act att caa cca att ata act tct gta     1182
 Gly Pro Asp Gly Gln Pro Gly Thr Ile Gln Pro Ile Ile Thr Ser Val
                 250                 255                 260

 cct ata aat tta tgg ggg aga gat tta tta caa caa tgg gga aca caa     1230
 Pro Ile Asn Leu Trp Gly Arg Asp Leu Leu Gln Gln Trp Gly Thr Gln
             265                 270                 275

 gtt cta att cca gaa caa tta tat agc cct caa aat caa cat atg atg     1278
 Val Leu Ile Pro Glu Gln Leu Tyr Ser Pro Gln Asn Gln His Met Met
         280                 285                 290

 cat gaa atg ggg tat gtc cct ggt atg gga cta gaa aaa aat ttg caa     1326
 His Glu Met Gly Tyr Val Pro Gly Met Gly Leu Glu Lys Asn Leu Gln
     295                 300                 305

 ggt ttg aaa gaa ccg ctt caa gca gaa aga caa aat tcc cgc caa aga     1374
 Gly Leu Lys Glu Pro Leu Gln Ala Glu Arg Gln Asn Ser Arg Gln Arg
 310                 315                 320                 325

 tta gga tat cat ttt tga                                             1392
 Leu Gly Tyr His Phe 
                 330





      <210> 248
      <211> 1140
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (100)..(660)

      <400> 248
 tcgccgttat ggccactggg ctgggcggct gaccgccggg ctaggaaagg gcccagggcc     60

 ccgaatctcg gtggccgctg ctccagcgcg gcctgcgcc   atg gcc tcc tcc gcc     114
                                              Met Ala Ser Ser Ala
                                                1               5

 gcc tcc tcg gag cat ttc gag aag ctg cac gag atc ttc cgc ggc ctc      162
 Ala Ser Ser Glu His Phe Glu Lys Leu His Glu Ile Phe Arg Gly Leu
                  10                  15                  20

 cat gaa gac ctg tct ttc cga aac ccc atg atg tct aag ctt cga aac      210
 His Glu Asp Leu Ser Phe Arg Asn Pro Met Met Ser Lys Leu Arg Asn
              25                  30                  35

 tac cgg aag gac ctt gct aaa ctc cat cgg gag gtg aga agc aca cct      258
 Tyr Arg Lys Asp Leu Ala Lys Leu His Arg Glu Val Arg Ser Thr Pro
          40                  45                  50

 ttg aca gcc aca cct gga ggc cga gga gac atg aaa tat ggc ata tat      306
 Leu Thr Ala Thr Pro Gly Gly Arg Gly Asp Met Lys Tyr Gly Ile Tyr
      55                  60                  65

 gct gta gag aat gag cat atg aat cgg cta cag tct caa agg gca atg      354
 Ala Val Glu Asn Glu His Met Asn Arg Leu Gln Ser Gln Arg Ala Met
  70                  75                  80                  85

 ctt ctg cag ggc act gaa agc ctg aac cgg gcc acc caa agt att gaa      402
 Leu Leu Gln Gly Thr Glu Ser Leu Asn Arg Ala Thr Gln Ser Ile Glu
                  90                  95                 100

 cgt tct cat cgg att gcc aca gag act gac cag att ggc tca gaa atc      450
 Arg Ser His Arg Ile Ala Thr Glu Thr Asp Gln Ile Gly Ser Glu Ile
             105                 110                 115

 ata gaa gag ctg ggg gaa caa cga gac cag tta gaa cgt acc aag agt      498
 Ile Glu Glu Leu Gly Glu Gln Arg Asp Gln Leu Glu Arg Thr Lys Ser
         120                 125                 130

 aga ctg gta aac aca agt gaa aac ttg agc aaa agt cgg aag att ctc      546
 Arg Leu Val Asn Thr Ser Glu Asn Leu Ser Lys Ser Arg Lys Ile Leu
     135                 140                 145

 cgt tca atg tcc aga aaa gtg aca acc aac aag ctg ctg ctt tcc att      594
 Arg Ser Met Ser Arg Lys Val Thr Thr Asn Lys Leu Leu Leu Ser Ile
 150                 155                 160                 165

 atc atc tta ctg gag ctc gcc atc ctg gga ggc ctg gtt tac tac aaa      642
 Ile Ile Leu Leu Glu Leu Ala Ile Leu Gly Gly Leu Val Tyr Tyr Lys
                 170                 175                 180

 ttc ttt cgc agc cat tga acttct atagggaagg gtttgtggac cagaactttg      696
 Phe Phe Arg Ser His 
             185

 accttgtgaa tgcatgatgt tagggatgtg gatagaataa gcatattgct gctgtgggct    756

 gacagttcaa ggatgcactg tatagccagg ctgtgggagg agggaggaaa gatgaaaaac    816

 cacttaaatg tgaaggaaca acagcaacaa gaccagtatg atatacccac ggtaagcaaa    876

 aacacaacaa taaccacaaa acaaagagaa aagaacgagg gcggcgccaa ccagaaaacc    936

 ccccagagga gcaacagaaa ccgcagcaca cgtatctgac aacaggggcc caccgtgaag    996

 cgcactatag acaacgacgg cgcgccaaaa caaccagaca gcggcaacga actgaggaac   1056

 cgacgacaac cacagggcag acaaaaggaa acgacaacag acaccagaac aaaacagcga   1116

 ccacacgtgc acaacaagat aaac                                          1140






      <210> 249
      <211> 10222
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (174)..(10172)

      <400> 249
 cacagacagg acgggagcgt caccgcgtgg agcaagggga gcggccccgg cgccgcccat     60

 atccccggct gcgctagtcc tggcgctgca ggtccgggag gcgcaggcgg agagcggcgg    120

 tgcccccgag cccctctgcg gacggctcag gcgggaggac cccgcgcggc tgg   atg     176
                                                              Met
                                                                1

 gcg gcg gcc gcg cgg cct cgg ggt cgg gca ctg ggg cca gta ctg ccg      224
 Ala Ala Ala Ala Arg Pro Arg Gly Arg Ala Leu Gly Pro Val Leu Pro
               5                  10                  15

 ccg acg ccg ctg ctc ctg ctg gta ctg cgg gtg ctg cca gcc tgc ggg      272
 Pro Thr Pro Leu Leu Leu Leu Val Leu Arg Val Leu Pro Ala Cys Gly
          20                  25                  30

 gcg acc gct cgg gat ccc ggg gcc gcg gcc ggg ctc agc ctt cac ccg      320
 Ala Thr Ala Arg Asp Pro Gly Ala Ala Ala Gly Leu Ser Leu His Pro
      35                  40                  45

 act tac ttc aac ctg gcc gag gcg gcg agg att tgg gcc acc gcc acc      368
 Thr Tyr Phe Asn Leu Ala Glu Ala Ala Arg Ile Trp Ala Thr Ala Thr
  50                  55                  60                  65

 tgc ggg gag agg gga ccc ggc gag ggg agg ccc cag ccc gag ctc tac      416
 Cys Gly Glu Arg Gly Pro Gly Glu Gly Arg Pro Gln Pro Glu Leu Tyr
                  70                  75                  80

 tgc aag ttg gtc ggg ggc ccc acc gcc cca ggc agc ggc cac acc atc      464
 Cys Lys Leu Val Gly Gly Pro Thr Ala Pro Gly Ser Gly His Thr Ile
              85                  90                  95

 cag ggc cag ttc tgt gac tat tgc aat tct gaa gac ccc agg aaa gca      512
 Gln Gly Gln Phe Cys Asp Tyr Cys Asn Ser Glu Asp Pro Arg Lys Ala
         100                 105                 110

 cat cct gtc acc aat gcc atc gat gga tct gaa cgt tgg tgg caa agc      560
 His Pro Val Thr Asn Ala Ile Asp Gly Ser Glu Arg Trp Trp Gln Ser
     115                 120                 125

 cct ccc ctg tcc tca ggc aca cag tac aac aga gtc aac ctc acc ttg      608
 Pro Pro Leu Ser Ser Gly Thr Gln Tyr Asn Arg Val Asn Leu Thr Leu
 130                 135                 140                 145

 gat ctg ggg cag ctc ttc cat gtg gcc tat att tta atc aaa ttt gca      656
 Asp Leu Gly Gln Leu Phe His Val Ala Tyr Ile Leu Ile Lys Phe Ala
                 150                 155                 160

 aat tct cct cgc cct gat ctt tgg gtc ttg gaa aga tct gta gac ttt      704
 Asn Ser Pro Arg Pro Asp Leu Trp Val Leu Glu Arg Ser Val Asp Phe
             165                 170                 175

 gga agc acc tac tca cca tgg caa tat ttt gct cat tct aaa gta gac      752
 Gly Ser Thr Tyr Ser Pro Trp Gln Tyr Phe Ala His Ser Lys Val Asp
         180                 185                 190

 tgt tta aaa gaa ttt ggg cgg gag gca aat atg gct gtc acc cgg gat      800
 Cys Leu Lys Glu Phe Gly Arg Glu Ala Asn Met Ala Val Thr Arg Asp
     195                 200                 205

 gat gat gta ctt tgt gtt act gaa tat tcc cgt att gta cct ttg gaa      848
 Asp Asp Val Leu Cys Val Thr Glu Tyr Ser Arg Ile Val Pro Leu Glu
 210                 215                 220                 225

 aat ggt gag gtt gtg gtg tcc ttg ata aac ggt cgt cca ggt gca aaa      896
 Asn Gly Glu Val Val Val Ser Leu Ile Asn Gly Arg Pro Gly Ala Lys
                 230                 235                 240

 aat ttt act ttc tct cac acc ctg agg gag ttt acc aag gca aca aac      944
 Asn Phe Thr Phe Ser His Thr Leu Arg Glu Phe Thr Lys Ala Thr Asn
             245                 250                 255

 atc cgc ttg cgt ttt ctt aga acc aat acg ctt ctt gga cac ctc atc      992
 Ile Arg Leu Arg Phe Leu Arg Thr Asn Thr Leu Leu Gly His Leu Ile
         260                 265                 270

 tcc aaa gcc cag cga gat cca act gtc act cgg cgg tat tat tac agc     1040
 Ser Lys Ala Gln Arg Asp Pro Thr Val Thr Arg Arg Tyr Tyr Tyr Ser
     275                 280                 285

 ata aag gac atc agc att ggt ggg cag tgt gtt tgc aat ggc cat gct     1088
 Ile Lys Asp Ile Ser Ile Gly Gly Gln Cys Val Cys Asn Gly His Ala
 290                 295                 300                 305

 gaa gtg tgc aat ata aac aat cct gaa aaa ctg ttt cgg tgt gaa tgc     1136
 Glu Val Cys Asn Ile Asn Asn Pro Glu Lys Leu Phe Arg Cys Glu Cys
                 310                 315                 320

 cag cac cac acc tgt ggg gag acg tgt gat cgc tgc tgc aca ggg tac     1184
 Gln His His Thr Cys Gly Glu Thr Cys Asp Arg Cys Cys Thr Gly Tyr
             325                 330                 335

 aat cag agg cgc tgg cgg ccc gcc gct tgg gag cag agc cac gag tgt     1232
 Asn Gln Arg Arg Trp Arg Pro Ala Ala Trp Glu Gln Ser His Glu Cys
         340                 345                 350

 gaa gca tgc aac tgc cac ggc cat gcc agc aac tgt tac tat gat cca     1280
 Glu Ala Cys Asn Cys His Gly His Ala Ser Asn Cys Tyr Tyr Asp Pro
     355                 360                 365

 gat gtt gag cgg cag cag gca agc ttg aat acc cag ggc atc tat gct     1328
 Asp Val Glu Arg Gln Gln Ala Ser Leu Asn Thr Gln Gly Ile Tyr Ala
 370                 375                 380                 385

 ggt gga ggg gtc tgc att aac tgt cag cac aac aca gct gga gta aac     1376
 Gly Gly Gly Val Cys Ile Asn Cys Gln His Asn Thr Ala Gly Val Asn
                 390                 395                 400

 tgt gaa cag tgt gct aag ggc tat tac cgc cct tat ggg gtt cca gtg     1424
 Cys Glu Gln Cys Ala Lys Gly Tyr Tyr Arg Pro Tyr Gly Val Pro Val
             405                 410                 415

 gat gcc cct gat ggc tgc atc ccc tgc agc tgt gac cct gag cat gcg     1472
 Asp Ala Pro Asp Gly Cys Ile Pro Cys Ser Cys Asp Pro Glu His Ala
         420                 425                 430

 gat ggc tgt gaa cag ggt tca ggc cgc tgt cac tgc aag cca aat ttc     1520
 Asp Gly Cys Glu Gln Gly Ser Gly Arg Cys His Cys Lys Pro Asn Phe
     435                 440                 445

 cac gga gac aac tgt gag aag tgt gca att gga tac aat ttc cca ttt     1568
 His Gly Asp Asn Cys Glu Lys Cys Ala Ile Gly Tyr Asn Phe Pro Phe
 450                 455                 460                 465

 tgc ttg aga act ccc att ttt cct gtt tct aca cca agt tca gaa gat     1616
 Cys Leu Arg Thr Pro Ile Phe Pro Val Ser Thr Pro Ser Ser Glu Asp
                 470                 475                 480

 cca gta gct gga gat ata aaa ggg tgt gac tgt aat ctg gaa ggt gtt     1664
 Pro Val Ala Gly Asp Ile Lys Gly Cys Asp Cys Asn Leu Glu Gly Val
             485                 490                 495

 ctc cct gaa ata tgt gat gcc cac gga cgg tgc ctg tgc cgc cct ggg     1712
 Leu Pro Glu Ile Cys Asp Ala His Gly Arg Cys Leu Cys Arg Pro Gly
         500                 505                 510

 gtt gag ggc cct cga tgt gat acc tgc cgc tct ggt ttc tac tca ttc     1760
 Val Glu Gly Pro Arg Cys Asp Thr Cys Arg Ser Gly Phe Tyr Ser Phe
     515                 520                 525

 cct att tgc caa gcc tgc tgg tgt tca gcc ctt gga tcc tac cag atg     1808
 Pro Ile Cys Gln Ala Cys Trp Cys Ser Ala Leu Gly Ser Tyr Gln Met
 530                 535                 540                 545

 ccc tgc agc tca gtg act gga cag tgt gaa tgt cgg cca gga gtt aca     1856
 Pro Cys Ser Ser Val Thr Gly Gln Cys Glu Cys Arg Pro Gly Val Thr
                 550                 555                 560

 gga cag cgg tgt gac agg tgt ctc tca gga gct tat gat ttc ccc cac     1904
 Gly Gln Arg Cys Asp Arg Cys Leu Ser Gly Ala Tyr Asp Phe Pro His
             565                 570                 575

 tgc caa ggt tcc agc agt gct tgt gac cca gct ggt acc atc aac tgg     1952
 Cys Gln Gly Ser Ser Ser Ala Cys Asp Pro Ala Gly Thr Ile Asn Trp
         580                 585                 590

 aat ttg ggg tat tgc caa tgc aag ctt cat gtt gaa ggt cct act tgt     2000
 Asn Leu Gly Tyr Cys Gln Cys Lys Leu His Val Glu Gly Pro Thr Cys
     595                 600                 605

 agc cgc tgc aaa ctg tta tat tgg aat ctg gac aaa gaa aac ccc agt     2048
 Ser Arg Cys Lys Leu Leu Tyr Trp Asn Leu Asp Lys Glu Asn Pro Ser
 610                 615                 620                 625

 gga tgt tca gaa tgc aag tgc cat aag ggg gga aca gtg agt gga act     2096
 Gly Cys Ser Glu Cys Lys Cys His Lys Gly Gly Thr Val Ser Gly Thr
                 630                 635                 640

 gga gag tgt agg cag gga gat ggt gac tgt cac tgc aag tcc cat gtg     2144
 Gly Glu Cys Arg Gln Gly Asp Gly Asp Cys His Cys Lys Ser His Val
             645                 650                 655

 ggt ggc gat tcc tgc gac acc tgt gaa gat gga tat ttt gct ttg gaa     2192
 Gly Gly Asp Ser Cys Asp Thr Cys Glu Asp Gly Tyr Phe Ala Leu Glu
         660                 665                 670

 aag agc aat tac ttt ggg tgt caa ggg tgt cag tgt gac att ggt ggg     2240
 Lys Ser Asn Tyr Phe Gly Cys Gln Gly Cys Gln Cys Asp Ile Gly Gly
     675                 680                 685

 gca ttg tcc tcc atg tgc agt ggg ccc tcg gga gtg tgc cag tgc cga     2288
 Ala Leu Ser Ser Met Cys Ser Gly Pro Ser Gly Val Cys Gln Cys Arg
 690                 695                 700                 705

 gag cat gtc gtg gga aag gtg tgc cag cgg cct gaa aac aac tac tat     2336
 Glu His Val Val Gly Lys Val Cys Gln Arg Pro Glu Asn Asn Tyr Tyr
                 710                 715                 720

 ttc cca gat ttg cat cat atg aag tat gag att gaa gac ggc agc aca     2384
 Phe Pro Asp Leu His His Met Lys Tyr Glu Ile Glu Asp Gly Ser Thr
             725                 730                 735

 cct aat ggg aga gac ctt cga ttt gga ttt gat ccg ctg gca ttt cct     2432
 Pro Asn Gly Arg Asp Leu Arg Phe Gly Phe Asp Pro Leu Ala Phe Pro
         740                 745                 750

 gag ttt agc tgg aga gga tat gcc caa atg gcc tca gta cag aat gat     2480
 Glu Phe Ser Trp Arg Gly Tyr Ala Gln Met Ala Ser Val Gln Asn Asp
     755                 760                 765

 gta aga ata aca ttg aat gta ggg aag tca agt ggc tcc ttg ttt cgt     2528
 Val Arg Ile Thr Leu Asn Val Gly Lys Ser Ser Gly Ser Leu Phe Arg
 770                 775                 780                 785

 gtt att ctg aga tac gtt aac cct gga act gaa gca gta tct ggc cat     2576
 Val Ile Leu Arg Tyr Val Asn Pro Gly Thr Glu Ala Val Ser Gly His
                 790                 795                 800

 ata act att tat cca tcc tgg ggt gct gct caa agc aaa gag atc atc     2624
 Ile Thr Ile Tyr Pro Ser Trp Gly Ala Ala Gln Ser Lys Glu Ile Ile
             805                 810                 815

 ttc ctg ccg agt aag gag cca gcc ttt gtc act ctc cct gga aat ggt     2672
 Phe Leu Pro Ser Lys Glu Pro Ala Phe Val Thr Leu Pro Gly Asn Gly
         820                 825                 830

 ttt gca gac cca ttt tca atc aca cca gga atg tgg gtt gct tgt att     2720
 Phe Ala Asp Pro Phe Ser Ile Thr Pro Gly Met Trp Val Ala Cys Ile
     835                 840                 845

 aag gca gaa gga gtc ctt ctg gat tac ctg gtg ctg ctc ccc agg gac     2768
 Lys Ala Glu Gly Val Leu Leu Asp Tyr Leu Val Leu Leu Pro Arg Asp
 850                 855                 860                 865

 tac tat gaa gcc tct gat ctg cag ctg cca gtc aca gaa cca tgt gcc     2816
 Tyr Tyr Glu Ala Ser Asp Leu Gln Leu Pro Val Thr Glu Pro Cys Ala
                 870                 875                 880

 tac gca gga cct ccc caa gaa aat tgc tta ctc tac cag cat ttg cca     2864
 Tyr Ala Gly Pro Pro Gln Glu Asn Cys Leu Leu Tyr Gln His Leu Pro
             885                 890                 895

 gtg acc aga ttc ccc tgt acc cgt tct tgt gag gcc aga cac ttc ctg     2912
 Val Thr Arg Phe Pro Cys Thr Arg Ser Cys Glu Ala Arg His Phe Leu
         900                 905                 910

 ctt gat ggg gag cca aga ccc gtg gca gtg agg cag ccc aca cct gca     2960
 Leu Asp Gly Glu Pro Arg Pro Val Ala Val Arg Gln Pro Thr Pro Ala
     915                 920                 925

 cac cct gtc atg gtg gac ctc agc ggg aga gag gtg gaa ttg cat ctg     3008
 His Pro Val Met Val Asp Leu Ser Gly Arg Glu Val Glu Leu His Leu
 930                 935                 940                 945

 cgc gtg cgc atc cca cag gtt gga ccc tac gtg gtt gtg gtc gag tat     3056
 Arg Val Arg Ile Pro Gln Val Gly Pro Tyr Val Val Val Val Glu Tyr
                 950                 955                 960

 tcc acg gag gca gcc cag ctg ttt gtg gtt gat gcg aat gtg aag agc     3104
 Ser Thr Glu Ala Ala Gln Leu Phe Val Val Asp Ala Asn Val Lys Ser
             965                 970                 975

 tcc ggg tct gtt ctg gca ggc cag gtg aac att tac agc tgc aac tac     3152
 Ser Gly Ser Val Leu Ala Gly Gln Val Asn Ile Tyr Ser Cys Asn Tyr
         980                 985                 990

 agt gtt ctc tgc cgg agt gct gtg att gat cac atg agc cgc atc gcc     3200
 Ser Val Leu Cys Arg Ser Ala Val Ile Asp His Met Ser Arg Ile Ala
     995                1000                1005

 atg tat gag cta tta aca gat gca gac att cag ctc aag gga cac atg     3248
 Met Tyr Glu Leu Leu Thr Asp Ala Asp Ile Gln Leu Lys Gly His Met
1010                1015                1020                1025

 gcc cga ttc ctt ctg cat caa gtt tgt atc ata cct att gaa gaa tac     3296
 Ala Arg Phe Leu Leu His Gln Val Cys Ile Ile Pro Ile Glu Glu Tyr
                1030                1035                1040

 tca gct gag tat gtg aga cca caa gtc cac tgc att gcc agt tat ggg     3344
 Ser Ala Glu Tyr Val Arg Pro Gln Val His Cys Ile Ala Ser Tyr Gly
            1045                1050                1055

 cga ttt gtc aat caa agt gcc acc tgt gtc tcc ttg gcc cat gaa act     3392
 Arg Phe Val Asn Gln Ser Ala Thr Cys Val Ser Leu Ala His Glu Thr
        1060                1065                1070

 cct cca aca gca tta att ttg gat gtt cta agt ggc agg ccc ttc cct     3440
 Pro Pro Thr Ala Leu Ile Leu Asp Val Leu Ser Gly Arg Pro Phe Pro
    1075                1080                1085

 cac ctg ccc cag cag tcg tca cct tct gtt gat gtt ctt cct ggg gtc     3488
 His Leu Pro Gln Gln Ser Ser Pro Ser Val Asp Val Leu Pro Gly Val
1090                1095                1100                1105

 acc ttg aag gca ccg cag aat caa gtg acc ctg aga gga cgt gta cca     3536
 Thr Leu Lys Ala Pro Gln Asn Gln Val Thr Leu Arg Gly Arg Val Pro
                1110                1115                1120

 cac ctg ggc cga tac gtc ttt gtc atc cat ttt tac caa gca gcg cac     3584
 His Leu Gly Arg Tyr Val Phe Val Ile His Phe Tyr Gln Ala Ala His
            1125                1130                1135

 ccg acg ttt ccc gcg cag gtg tcg gtg gat ggc ggg tgg cca cgg gca     3632
 Pro Thr Phe Pro Ala Gln Val Ser Val Asp Gly Gly Trp Pro Arg Ala
        1140                1145                1150

 ggc tcc ttc cat gcc tct ttt tgc ccc cat gtg ctt ggc tgc cgg gat     3680
 Gly Ser Phe His Ala Ser Phe Cys Pro His Val Leu Gly Cys Arg Asp
    1155                1160                1165

 caa gtg att gcc gaa ggc cag att gag ttt gac atc tca gag cct gaa     3728
 Gln Val Ile Ala Glu Gly Gln Ile Glu Phe Asp Ile Ser Glu Pro Glu
1170                1175                1180                1185

 gtg gcc gca act gtg aag gtt cca gaa gga aag tcc ttg gtt ttg gtc     3776
 Val Ala Ala Thr Val Lys Val Pro Glu Gly Lys Ser Leu Val Leu Val
                1190                1195                1200

 cgt gtt cta gtg gtg cct gca gaa aac tat gac tac caa ata ctt cac     3824
 Arg Val Leu Val Val Pro Ala Glu Asn Tyr Asp Tyr Gln Ile Leu His
            1205                1210                1215

 aaa aaa tcc atg gac aag tca ctc gag ttt atc acc aat tgt gga aaa     3872
 Lys Lys Ser Met Asp Lys Ser Leu Glu Phe Ile Thr Asn Cys Gly Lys
        1220                1225                1230

 aac agc ttt tac ctt gac ccc cag aca gcc tcc aga ttc tgt aag aat     3920
 Asn Ser Phe Tyr Leu Asp Pro Gln Thr Ala Ser Arg Phe Cys Lys Asn
    1235                1240                1245

 tcc gcc agg tcc ctg gtg gcc ttt tac cac aag ggc gcc ctg cct tgt     3968
 Ser Ala Arg Ser Leu Val Ala Phe Tyr His Lys Gly Ala Leu Pro Cys
1250                1255                1260                1265

 gag tgc cac ccc act ggg gcc acc ggc cct cac tgc agc cct gag ggt     4016
 Glu Cys His Pro Thr Gly Ala Thr Gly Pro His Cys Ser Pro Glu Gly
                1270                1275                1280

 ggg cag tgc cca tgc cag ccc aac gtc atc ggg cgg cag tgc acc cgc     4064
 Gly Gln Cys Pro Cys Gln Pro Asn Val Ile Gly Arg Gln Cys Thr Arg
            1285                1290                1295

 tgt gca aca ggc cac tac gga ttc cca cgc tgc aag ccg tgc agc tgt     4112
 Cys Ala Thr Gly His Tyr Gly Phe Pro Arg Cys Lys Pro Cys Ser Cys
        1300                1305                1310

 ggt cgg cgc ctt tgt gaa gag atg acg ggg cag tgc cgc tgc cct ccc     4160
 Gly Arg Arg Leu Cys Glu Glu Met Thr Gly Gln Cys Arg Cys Pro Pro
    1315                1320                1325

 cgc acg gtc agg ccc cag tgt gag gtg tgt gag aca cac tca ttc agc     4208
 Arg Thr Val Arg Pro Gln Cys Glu Val Cys Glu Thr His Ser Phe Ser
1330                1335                1340                1345

 ttc cac ccc atg gcc ggc tgc gaa ggc tgc aac tgt tcc agg agg ggc     4256
 Phe His Pro Met Ala Gly Cys Glu Gly Cys Asn Cys Ser Arg Arg Gly
                1350                1355                1360

 acc atc gag gct gcc atg ccg gag tgt gac cgg gac agc ggg cag tgc     4304
 Thr Ile Glu Ala Ala Met Pro Glu Cys Asp Arg Asp Ser Gly Gln Cys
            1365                1370                1375

 aga tgc aag ccc aga atc aca ggg cgg cag tgt gac cga tgt gct tcc     4352
 Arg Cys Lys Pro Arg Ile Thr Gly Arg Gln Cys Asp Arg Cys Ala Ser
        1380                1385                1390

 ggg ttt tac cgc ttt cct gag tgt gtt ccc tgc aat tgc aac aga gat     4400
 Gly Phe Tyr Arg Phe Pro Glu Cys Val Pro Cys Asn Cys Asn Arg Asp
    1395                1400                1405

 ggg act gag cca gga gtg tgt gac cca ggc acc ggg gct tgc ctc tgc     4448
 Gly Thr Glu Pro Gly Val Cys Asp Pro Gly Thr Gly Ala Cys Leu Cys
1410                1415                1420                1425

 aag gaa aat gta gaa ggc aca gag tgt aat gtg tgt cga gaa ggc tca     4496
 Lys Glu Asn Val Glu Gly Thr Glu Cys Asn Val Cys Arg Glu Gly Ser
                1430                1435                1440

 ttc cat ttg gac cca gcc aat ctc aag ggt tgt acc agc tgt ttc tgt     4544
 Phe His Leu Asp Pro Ala Asn Leu Lys Gly Cys Thr Ser Cys Phe Cys
            1445                1450                1455

 ttt gga gta aat aat caa tgt cac agc tca cat aag cga agg act aag     4592
 Phe Gly Val Asn Asn Gln Cys His Ser Ser His Lys Arg Arg Thr Lys
        1460                1465                1470

 ttt gtg gat atg ctg ggc tgg cac ctg gag aca gca gac aga gtg gac     4640
 Phe Val Asp Met Leu Gly Trp His Leu Glu Thr Ala Asp Arg Val Asp
    1475                1480                1485

 atc cct gtc tct ttc aac cca ggc agc aac agt atg gtg gcg gat ctc     4688
 Ile Pro Val Ser Phe Asn Pro Gly Ser Asn Ser Met Val Ala Asp Leu
1490                1495                1500                1505

 cag gag ctg ccc gca acc atc cac agc gcg tcc tgg gtc gca ccc acc     4736
 Gln Glu Leu Pro Ala Thr Ile His Ser Ala Ser Trp Val Ala Pro Thr
                1510                1515                1520

 tcc tac ctg ggg gac aag gtt tct tca tat ggt ggt tac ctc act tac     4784
 Ser Tyr Leu Gly Asp Lys Val Ser Ser Tyr Gly Gly Tyr Leu Thr Tyr
            1525                1530                1535

 caa gcc aag tcc ttt ggc ttg cct ggc gac atg gtt ctt ctg gaa aag     4832
 Gln Ala Lys Ser Phe Gly Leu Pro Gly Asp Met Val Leu Leu Glu Lys
        1540                1545                1550

 aag ccg gat gta cag ctc act ggt cag cac atg tcc atc atc tat gag     4880
 Lys Pro Asp Val Gln Leu Thr Gly Gln His Met Ser Ile Ile Tyr Glu
    1555                1560                1565

 gag aca aac acc cca cgg cca gac cgg ctg cat cat gga cga gtg cac     4928
 Glu Thr Asn Thr Pro Arg Pro Asp Arg Leu His His Gly Arg Val His
1570                1575                1580                1585

 gtg gtc gag gga aac ttc aga cat gcc agc agc cgt gcc cca gtg tct     4976
 Val Val Glu Gly Asn Phe Arg His Ala Ser Ser Arg Ala Pro Val Ser
                1590                1595                1600

 agg gag gag ctg atg aca gtg ctg tct aga ctg gca gat gtg cgc atc     5024
 Arg Glu Glu Leu Met Thr Val Leu Ser Arg Leu Ala Asp Val Arg Ile
            1605                1610                1615

 caa ggc ctc tac ttc aca gag act caa agg ctc acc ctg agc gag gtg     5072
 Gln Gly Leu Tyr Phe Thr Glu Thr Gln Arg Leu Thr Leu Ser Glu Val
        1620                1625                1630

 ggg cta gag gaa gcc tct gac aca gga agt ggg cgc ata gca ctt gct     5120
 Gly Leu Glu Glu Ala Ser Asp Thr Gly Ser Gly Arg Ile Ala Leu Ala
    1635                1640                1645

 gtg gaa atc tgt gcc tgc ccc cct gcc tac gct ggt gac tct tgt cag     5168
 Val Glu Ile Cys Ala Cys Pro Pro Ala Tyr Ala Gly Asp Ser Cys Gln
1650                1655                1660                1665

 ggt tgt agc cct gga tac tat cgg gat cat aaa ggc ttg tat acc gga     5216
 Gly Cys Ser Pro Gly Tyr Tyr Arg Asp His Lys Gly Leu Tyr Thr Gly
                1670                1675                1680

 cgg tgt gtt ccc tgc aat tgc aac gga cat tca aat caa tgc cag gat     5264
 Arg Cys Val Pro Cys Asn Cys Asn Gly His Ser Asn Gln Cys Gln Asp
            1685                1690                1695

 ggc tca ggc ata tgt gtt aac tgt cag cac aac acc gcg gga gag cac     5312
 Gly Ser Gly Ile Cys Val Asn Cys Gln His Asn Thr Ala Gly Glu His
        1700                1705                1710

 tgt gaa cgc tgc cag gag ggc tac tat ggc aac gcc gtc cac gga tcc     5360
 Cys Glu Arg Cys Gln Glu Gly Tyr Tyr Gly Asn Ala Val His Gly Ser
    1715                1720                1725

 tgc agg gcc tgc cca tgt cct cac act aac agc ttt gcc act ggc tgt     5408
 Cys Arg Ala Cys Pro Cys Pro His Thr Asn Ser Phe Ala Thr Gly Cys
1730                1735                1740                1745

 gtg gtg aat ggg gga gac gtg cgg tgc tcc tgc aaa gct ggg tac aca     5456
 Val Val Asn Gly Gly Asp Val Arg Cys Ser Cys Lys Ala Gly Tyr Thr
                1750                1755                1760

 gga aca cag tgt gaa agg tgt gca ccg gga tat ttc ggg aat ccc cag     5504
 Gly Thr Gln Cys Glu Arg Cys Ala Pro Gly Tyr Phe Gly Asn Pro Gln
            1765                1770                1775

 aaa ttc gga ggt agc tgc caa cca tgc agt tgt aac agc aat ggc cag     5552
 Lys Phe Gly Gly Ser Cys Gln Pro Cys Ser Cys Asn Ser Asn Gly Gln
        1780                1785                1790

 ctg ggc agc tgt cat ccc ctg act gga gac tgc ata aac caa gaa ccc     5600
 Leu Gly Ser Cys His Pro Leu Thr Gly Asp Cys Ile Asn Gln Glu Pro
    1795                1800                1805

 aaa gat agc agc cct gca gaa gaa tgt gat gat tgc gac agc tgt gtg     5648
 Lys Asp Ser Ser Pro Ala Glu Glu Cys Asp Asp Cys Asp Ser Cys Val
1810                1815                1820                1825

 atg acc ctc ctg aac gac ctg gcc acc atg ggc gag cag ctc cgc ctg     5696
 Met Thr Leu Leu Asn Asp Leu Ala Thr Met Gly Glu Gln Leu Arg Leu
                1830                1835                1840

 gtc aag tct cag ctg cag ggc ctg agt gcc agc gca ggg ctt ctg gag     5744
 Val Lys Ser Gln Leu Gln Gly Leu Ser Ala Ser Ala Gly Leu Leu Glu
            1845                1850                1855

 cag atg agg cac atg gag acc cag gcc aag gac ctg agg aat cag ttg     5792
 Gln Met Arg His Met Glu Thr Gln Ala Lys Asp Leu Arg Asn Gln Leu
        1860                1865                1870

 ctc aac tac cgt tct gcc att tca aat cat gga tca aaa ata gaa ggc     5840
 Leu Asn Tyr Arg Ser Ala Ile Ser Asn His Gly Ser Lys Ile Glu Gly
    1875                1880                1885

 ctg gaa aga gaa ctg act gat ttg aat caa gaa ttt gag act ttg caa     5888
 Leu Glu Arg Glu Leu Thr Asp Leu Asn Gln Glu Phe Glu Thr Leu Gln
1890                1895                1900                1905

 gaa aag gct caa gta aat tcc aga aaa gca caa aca tta aac aac aat     5936
 Glu Lys Ala Gln Val Asn Ser Arg Lys Ala Gln Thr Leu Asn Asn Asn
                1910                1915                1920

 gtt aat cgg gca aca caa agc gca aaa gaa ctg gat gtg aag att aaa     5984
 Val Asn Arg Ala Thr Gln Ser Ala Lys Glu Leu Asp Val Lys Ile Lys
            1925                1930                1935

 aat gtc atc cgg aat gtg cac att ctt tta aag cag atc tct ggg aca     6032
 Asn Val Ile Arg Asn Val His Ile Leu Leu Lys Gln Ile Ser Gly Thr
        1940                1945                1950

 gat gga gag gga aac aac gtg cct tca ggt gac ttt tcc aga gag tgg     6080
 Asp Gly Glu Gly Asn Asn Val Pro Ser Gly Asp Phe Ser Arg Glu Trp
    1955                1960                1965

 gct gaa gcc cag cgc atg atg agg gaa ctg cgg aac agg aac ttt gga     6128
 Ala Glu Ala Gln Arg Met Met Arg Glu Leu Arg Asn Arg Asn Phe Gly
1970                1975                1980                1985

 aag cac ctc aga gaa gca gaa gct gat aaa agg gag tcg cag ctc ttg     6176
 Lys His Leu Arg Glu Ala Glu Ala Asp Lys Arg Glu Ser Gln Leu Leu
                1990                1995                2000

 ctg aac cgg ata agg acc tgg cag aaa acc cac cag ggg gag aac aat     6224
 Leu Asn Arg Ile Arg Thr Trp Gln Lys Thr His Gln Gly Glu Asn Asn
            2005                2010                2015

 ggg ctt gct aac agt atc cgg gat tct tta aat gaa tac gaa gcc aaa     6272
 Gly Leu Ala Asn Ser Ile Arg Asp Ser Leu Asn Glu Tyr Glu Ala Lys
        2020                2025                2030

 ctc agt gac ctt cgt gct cgg ctg cag gag gca gct gcc caa gcc aag     6320
 Leu Ser Asp Leu Arg Ala Arg Leu Gln Glu Ala Ala Ala Gln Ala Lys
    2035                2040                2045

 cag gca aat ggc ttg aac caa gaa aac gag aga gct ttg gga gcc att     6368
 Gln Ala Asn Gly Leu Asn Gln Glu Asn Glu Arg Ala Leu Gly Ala Ile
2050                2055                2060                2065

 cag aga caa gtg aaa gaa ata aat tcc ctg cag agt gat ttc acc aag     6416
 Gln Arg Gln Val Lys Glu Ile Asn Ser Leu Gln Ser Asp Phe Thr Lys
                2070                2075                2080

 tat cta acc act gca gac tca tct ttg ttg caa acc aac att gcg ctg     6464
 Tyr Leu Thr Thr Ala Asp Ser Ser Leu Leu Gln Thr Asn Ile Ala Leu
            2085                2090                2095

 cag ctg atg gag aaa agc cag aag gaa tat gaa aaa tta gct gcc agt     6512
 Gln Leu Met Glu Lys Ser Gln Lys Glu Tyr Glu Lys Leu Ala Ala Ser
        2100                2105                2110

 tta aat gaa gca aga caa gaa cta agt gac aaa gta aga gaa ctt tcc     6560
 Leu Asn Glu Ala Arg Gln Glu Leu Ser Asp Lys Val Arg Glu Leu Ser
    2115                2120                2125

 aga tct gct ggc aaa aca tcc ctt gtg gag gag gca gaa aag cac gcg     6608
 Arg Ser Ala Gly Lys Thr Ser Leu Val Glu Glu Ala Glu Lys His Ala
2130                2135                2140                2145

 cgg tcc tta caa gag ctg gca aag cag ctg gaa gag atc aag aga aac     6656
 Arg Ser Leu Gln Glu Leu Ala Lys Gln Leu Glu Glu Ile Lys Arg Asn
                2150                2155                2160

 gcc agc ggg gat gag ctg gtg cgc tgt gct gtg gat gcc gcc acc gcc     6704
 Ala Ser Gly Asp Glu Leu Val Arg Cys Ala Val Asp Ala Ala Thr Ala
            2165                2170                2175

 tac gag aac atc ctc aat gcc atc aaa gcg gcc gag gac gca gcc aac     6752
 Tyr Glu Asn Ile Leu Asn Ala Ile Lys Ala Ala Glu Asp Ala Ala Asn
        2180                2185                2190

 agg gct gcc agt gca tct gaa tct gcc ctc cag aca gtg ata aag gaa     6800
 Arg Ala Ala Ser Ala Ser Glu Ser Ala Leu Gln Thr Val Ile Lys Glu
    2195                2200                2205

 gat ctg cca aga aaa gct aaa acc ctg agt tcc aac agt gat aaa ctg     6848
 Asp Leu Pro Arg Lys Ala Lys Thr Leu Ser Ser Asn Ser Asp Lys Leu
2210                2215                2220                2225

 tta aat gaa gcc aag atg aca caa aag aag cta aag caa gaa gtc agt     6896
 Leu Asn Glu Ala Lys Met Thr Gln Lys Lys Leu Lys Gln Glu Val Ser
                2230                2235                2240

 cca gct ctc aac aac cta cag caa acc ctg aat att gtg aca gtt cag     6944
 Pro Ala Leu Asn Asn Leu Gln Gln Thr Leu Asn Ile Val Thr Val Gln
            2245                2250                2255

 aaa gaa gtg ata gac acc aat ctc aca act ctc cga gat ggt ctt cat     6992
 Lys Glu Val Ile Asp Thr Asn Leu Thr Thr Leu Arg Asp Gly Leu His
        2260                2265                2270

 ggg ata cag aga ggt gat att gat gct atg atc agt agt gca aag agc     7040
 Gly Ile Gln Arg Gly Asp Ile Asp Ala Met Ile Ser Ser Ala Lys Ser
    2275                2280                2285

 atg gtc aga aag gcc aac gac atc aca gat gag gtt ctg gat ggg ctc     7088
 Met Val Arg Lys Ala Asn Asp Ile Thr Asp Glu Val Leu Asp Gly Leu
2290                2295                2300                2305

 aac ccc atc cag aca gat gtg gaa aga att aag gac acc tat ggg agg     7136
 Asn Pro Ile Gln Thr Asp Val Glu Arg Ile Lys Asp Thr Tyr Gly Arg
                2310                2315                2320

 aca cag aac gaa gac ttc aaa aag gct ctg act gat gca gat aac tcg     7184
 Thr Gln Asn Glu Asp Phe Lys Lys Ala Leu Thr Asp Ala Asp Asn Ser
            2325                2330                2335

 gtg aat aag tta acc aac aaa cta cct gat ctt tgg cgc aag att gaa     7232
 Val Asn Lys Leu Thr Asn Lys Leu Pro Asp Leu Trp Arg Lys Ile Glu
        2340                2345                2350

 agt atc aac caa cag ctg ttg ccc ttg gga aac atc tct gac aac atg     7280
 Ser Ile Asn Gln Gln Leu Leu Pro Leu Gly Asn Ile Ser Asp Asn Met
    2355                2360                2365

 gac aga ata cga gaa cta att cag cag gcc aga gat gct gcc agt aag     7328
 Asp Arg Ile Arg Glu Leu Ile Gln Gln Ala Arg Asp Ala Ala Ser Lys
2370                2375                2380                2385

 gtt gct gtc ccc atg agg ttc aat ggt aaa tct gga gtc gaa gtc cga     7376
 Val Ala Val Pro Met Arg Phe Asn Gly Lys Ser Gly Val Glu Val Arg
                2390                2395                2400

 ctg cca aat gac ctg gaa gat ttg aaa gga tat aca tct ctg tcc ttg     7424
 Leu Pro Asn Asp Leu Glu Asp Leu Lys Gly Tyr Thr Ser Leu Ser Leu
            2405                2410                2415

 ttt ctc caa agg ccc aac tca aga gaa aat ggg ggt act gag aat atg     7472
 Phe Leu Gln Arg Pro Asn Ser Arg Glu Asn Gly Gly Thr Glu Asn Met
        2420                2425                2430

 ttt gtg atg tac ctt gga aat aaa gat gcc tcc cgg gac tac atc ggc     7520
 Phe Val Met Tyr Leu Gly Asn Lys Asp Ala Ser Arg Asp Tyr Ile Gly
    2435                2440                2445

 atg gca gtt gtg gat ggc cag ctc acc tgt gtc tac aac ctg ggg gac     7568
 Met Ala Val Val Asp Gly Gln Leu Thr Cys Val Tyr Asn Leu Gly Asp
2450                2455                2460                2465

 cgt gag gct gaa ctc caa gtg gac cag atc ttg acc aag agt gag act     7616
 Arg Glu Ala Glu Leu Gln Val Asp Gln Ile Leu Thr Lys Ser Glu Thr
                2470                2475                2480

 aag gag gca gtt atg gat cgg gtg aaa ttt cag aga att tat cag ttt     7664
 Lys Glu Ala Val Met Asp Arg Val Lys Phe Gln Arg Ile Tyr Gln Phe
            2485                2490                2495

 gca agg ctt aat tac acc aaa gga gcc aca tcc agt aaa cca gaa aca     7712
 Ala Arg Leu Asn Tyr Thr Lys Gly Ala Thr Ser Ser Lys Pro Glu Thr
        2500                2505                2510

 ccc gga gtc tat gac atg gat ggt aga aat agc aat aca ctc ctt aat     7760
 Pro Gly Val Tyr Asp Met Asp Gly Arg Asn Ser Asn Thr Leu Leu Asn
    2515                2520                2525

 ttg gat cct gaa aat gtt gta ttt tat gtt gga ggt tac cca cct gat     7808
 Leu Asp Pro Glu Asn Val Val Phe Tyr Val Gly Gly Tyr Pro Pro Asp
2530                2535                2540                2545

 ttt aaa ctt ccc agt cga cta agt ttc cct cca tac aaa ggt tgt att     7856
 Phe Lys Leu Pro Ser Arg Leu Ser Phe Pro Pro Tyr Lys Gly Cys Ile
                2550                2555                2560

 gaa tta gat gac ctc aat gaa aat gtt ctg agc ttg tac aac ttc aaa     7904
 Glu Leu Asp Asp Leu Asn Glu Asn Val Leu Ser Leu Tyr Asn Phe Lys
            2565                2570                2575

 aaa aca ttc aat ctc aac aca act gaa gtg gag cct tgt aga agg agg     7952
 Lys Thr Phe Asn Leu Asn Thr Thr Glu Val Glu Pro Cys Arg Arg Arg
        2580                2585                2590

 aag gaa gag tca gac aaa aat tat ttt gaa ggt acg ggc tat gct cga     8000
 Lys Glu Glu Ser Asp Lys Asn Tyr Phe Glu Gly Thr Gly Tyr Ala Arg
    2595                2600                2605

 gtt cca act caa cca cat gct ccc atc cca acc ttt gga cag aca att     8048
 Val Pro Thr Gln Pro His Ala Pro Ile Pro Thr Phe Gly Gln Thr Ile
2610                2615                2620                2625

 cag acc acc gtg gat aga ggc ttg ctg ttc ttt gca gaa aac ggg gat     8096
 Gln Thr Thr Val Asp Arg Gly Leu Leu Phe Phe Ala Glu Asn Gly Asp
                2630                2635                2640

 cgc ttc ata tct cta aat ata gaa gat ggc aag ctc atg gtg aga tac     8144
 Arg Phe Ile Ser Leu Asn Ile Glu Asp Gly Lys Leu Met Val Arg Tyr
            2645                2650                2655

 aaa ctg aat tca gag cta cca aaa gag aga gga gtt gga gac gcc ata     8192
 Lys Leu Asn Ser Glu Leu Pro Lys Glu Arg Gly Val Gly Asp Ala Ile
        2660                2665                2670

 aac aac ggc aga gac cat tcg att cag atc aaa att gga aaa ctc caa     8240
 Asn Asn Gly Arg Asp His Ser Ile Gln Ile Lys Ile Gly Lys Leu Gln
    2675                2680                2685

 aag cgt atg tgg ata aat gtg gac gtt caa aac act ata att gat ggt     8288
 Lys Arg Met Trp Ile Asn Val Asp Val Gln Asn Thr Ile Ile Asp Gly
2690                2695                2700                2705

 gaa gta ttt gat ttc agc aca tat tat ctg gga gga att cca att gca     8336
 Glu Val Phe Asp Phe Ser Thr Tyr Tyr Leu Gly Gly Ile Pro Ile Ala
                2710                2715                2720

 atc agg gaa aga ttt aac att tct acg cct gct ttc cga ggc tgc atg     8384
 Ile Arg Glu Arg Phe Asn Ile Ser Thr Pro Ala Phe Arg Gly Cys Met
            2725                2730                2735

 aaa aat ttg aag aaa acc agt ggt gtc gtt aga ttg aat gat act gtg     8432
 Lys Asn Leu Lys Lys Thr Ser Gly Val Val Arg Leu Asn Asp Thr Val
        2740                2745                2750

 gga gta acc aaa aag tgc tcg gaa gac tgg aag ctt gtg cga tct gcc     8480
 Gly Val Thr Lys Lys Cys Ser Glu Asp Trp Lys Leu Val Arg Ser Ala
    2755                2760                2765

 tca ttc tcc aga gga gga caa ttg agt ttc act gat ttg ggc tta cca     8528
 Ser Phe Ser Arg Gly Gly Gln Leu Ser Phe Thr Asp Leu Gly Leu Pro
2770                2775                2780                2785

 cct act gac cac ctc cag gcc tca ttt gga ttt cag acc ttt caa ccc     8576
 Pro Thr Asp His Leu Gln Ala Ser Phe Gly Phe Gln Thr Phe Gln Pro
                2790                2795                2800

 agt ggc ata tta tta gat cat cag aca tgg aca agg aac ctg cag gtc     8624
 Ser Gly Ile Leu Leu Asp His Gln Thr Trp Thr Arg Asn Leu Gln Val
            2805                2810                2815

 act ctg gaa gat ggt tac att gaa ttg agc acc agc gat agc ggc ggc     8672
 Thr Leu Glu Asp Gly Tyr Ile Glu Leu Ser Thr Ser Asp Ser Gly Gly
        2820                2825                2830

 cca att ttt aaa tct cca cag acg tat atg gat ggt tta ctg cat tat     8720
 Pro Ile Phe Lys Ser Pro Gln Thr Tyr Met Asp Gly Leu Leu His Tyr
    2835                2840                2845

 gta tct gta ata agc gac aac tct gga cta cgg ctt ctc atc gat gac     8768
 Val Ser Val Ile Ser Asp Asn Ser Gly Leu Arg Leu Leu Ile Asp Asp
2850                2855                2860                2865

 cag ctt ctg aga aat agc aaa agg cta aaa cac att tca agt tcc cgg     8816
 Gln Leu Leu Arg Asn Ser Lys Arg Leu Lys His Ile Ser Ser Ser Arg
                2870                2875                2880

 cag tct ctg cgt ctg ggc ggg agc aat ttt gag ggt tgt att agc aat     8864
 Gln Ser Leu Arg Leu Gly Gly Ser Asn Phe Glu Gly Cys Ile Ser Asn
            2885                2890                2895

 gtt ttt gtc cag agg tta tca ctg agt cct gaa gtc cta gat ttg acc     8912
 Val Phe Val Gln Arg Leu Ser Leu Ser Pro Glu Val Leu Asp Leu Thr
        2900                2905                2910

 agt aac tct ctc aag aga gat gtg tcc ctg gga ggc tgc agt tta aac     8960
 Ser Asn Ser Leu Lys Arg Asp Val Ser Leu Gly Gly Cys Ser Leu Asn
    2915                2920                2925

 aaa cca cct ttt cta atg ttg ctt aaa ggt tct acc agg ttt aac aag     9008
 Lys Pro Pro Phe Leu Met Leu Leu Lys Gly Ser Thr Arg Phe Asn Lys
2930                2935                2940                2945

 acc aag act ttt cgt atc aac cag ctg ttg cag gac aca cca gtg gcc     9056
 Thr Lys Thr Phe Arg Ile Asn Gln Leu Leu Gln Asp Thr Pro Val Ala
                2950                2955                2960

 tcc cca agg agc gtg aag gtg tgg caa gat gct tgc tca cca ctt ccc     9104
 Ser Pro Arg Ser Val Lys Val Trp Gln Asp Ala Cys Ser Pro Leu Pro
            2965                2970                2975

 aag acc cag gcc aat cat gga gcc ctc cag ttt ggg gac att ccc acc     9152
 Lys Thr Gln Ala Asn His Gly Ala Leu Gln Phe Gly Asp Ile Pro Thr
        2980                2985                2990

 agc cac ttg cta ttc aag ctt cct cag gag ctg ctg aaa ccc agg tca     9200
 Ser His Leu Leu Phe Lys Leu Pro Gln Glu Leu Leu Lys Pro Arg Ser
    2995                3000                3005

 cag ttt gct gtg gac atg cag aca aca tcc tcc aga gga ctg gtg ttt     9248
 Gln Phe Ala Val Asp Met Gln Thr Thr Ser Ser Arg Gly Leu Val Phe
3010                3015                3020                3025

 cac acg ggc act aag aac tcc ttt atg gct ctt tat ctt tca aaa gga     9296
 His Thr Gly Thr Lys Asn Ser Phe Met Ala Leu Tyr Leu Ser Lys Gly
                3030                3035                3040

 cgt ctg gtc ttt gca ctg ggg aca gat ggg aaa aaa ttg agg atc aaa     9344
 Arg Leu Val Phe Ala Leu Gly Thr Asp Gly Lys Lys Leu Arg Ile Lys
            3045                3050                3055

 agc aag gag aaa tgc aat gat ggg aaa tgg cac acg gtg gtg ttt ggc     9392
 Ser Lys Glu Lys Cys Asn Asp Gly Lys Trp His Thr Val Val Phe Gly
        3060                3065                3070

 cat gat ggg gaa aag ggg cgc ttg gtt gtg gat gga ctg agg gcc cgg     9440
 His Asp Gly Glu Lys Gly Arg Leu Val Val Asp Gly Leu Arg Ala Arg
    3075                3080                3085

 gag gga agt ttg cct gga aac tcc acc atc agc atc aga gcg cca gtt     9488
 Glu Gly Ser Leu Pro Gly Asn Ser Thr Ile Ser Ile Arg Ala Pro Val
3090                3095                3100                3105

 tac ctg gga tca cct cca tca ggg aaa cca aag agc ctc ccc aca aac     9536
 Tyr Leu Gly Ser Pro Pro Ser Gly Lys Pro Lys Ser Leu Pro Thr Asn
                3110                3115                3120

 agc ttt gtg gga tgc ctg aag aac ttt cag ctg gat tca aaa ccc ttg     9584
 Ser Phe Val Gly Cys Leu Lys Asn Phe Gln Leu Asp Ser Lys Pro Leu
            3125                3130                3135

 tat acc cct tct tca agc ttc ggg gtg tct tcc tgc ttg ggt ggt cct     9632
 Tyr Thr Pro Ser Ser Ser Phe Gly Val Ser Ser Cys Leu Gly Gly Pro
        3140                3145                3150

 ttg gag aaa ggc att tat ttc tct gaa gaa gga ggt cat gtc gtc ttg     9680
 Leu Glu Lys Gly Ile Tyr Phe Ser Glu Glu Gly Gly His Val Val Leu
    3155                3160                3165

 gct cac tct gta ttg ttg ggg cca gaa ttt aag ctt gtt ttc agc atc     9728
 Ala His Ser Val Leu Leu Gly Pro Glu Phe Lys Leu Val Phe Ser Ile
3170                3175                3180                3185

 cgc cca aga agt ctc act ggg atc cta ata cac atc gga agt cag ccc     9776
 Arg Pro Arg Ser Leu Thr Gly Ile Leu Ile His Ile Gly Ser Gln Pro
                3190                3195                3200

 ggg aag cac tta tgt gtt tac ctg gag gca gga aag gtc acg gcc tct     9824
 Gly Lys His Leu Cys Val Tyr Leu Glu Ala Gly Lys Val Thr Ala Ser
            3205                3210                3215

 atg gac agt ggg gca ggt ggg acc tca acg tcg gtc aca cca aag cag     9872
 Met Asp Ser Gly Ala Gly Gly Thr Ser Thr Ser Val Thr Pro Lys Gln
        3220                3225                3230

 tct ctg tgt gat gga cag tgg cac tcg gtg gca gtc acc ata aaa caa     9920
 Ser Leu Cys Asp Gly Gln Trp His Ser Val Ala Val Thr Ile Lys Gln
    3235                3240                3245

 cac atc ctg cac ctg gaa ctg gac aca gac agt agc tac aca gct gga     9968
 His Ile Leu His Leu Glu Leu Asp Thr Asp Ser Ser Tyr Thr Ala Gly
3250                3255                3260                3265

 cag atc ccc ttc cca cct gcc agc act caa gag cca cta cac ctt gga    10016
 Gln Ile Pro Phe Pro Pro Ala Ser Thr Gln Glu Pro Leu His Leu Gly
                3270                3275                3280

 ggt gct cca gcc aat ttg acg aca ctg agg atc cct gtg tgg aaa tca    10064
 Gly Ala Pro Ala Asn Leu Thr Thr Leu Arg Ile Pro Val Trp Lys Ser
            3285                3290                3295

 ttc ttt ggc tgt ctg agg aat att cat gtc aat cac atc cct gtc cct    10112
 Phe Phe Gly Cys Leu Arg Asn Ile His Val Asn His Ile Pro Val Pro
        3300                3305                3310

 gtc act gaa gcc ttg gaa gtc cag ggg cct gtc agt ctg aat ggt tgt    10160
 Val Thr Glu Ala Leu Glu Val Gln Gly Pro Val Ser Leu Asn Gly Cys
    3315                3320                3325

 cct gac cag taa ccc aagcctattt cacagcaagg aaattcacct tcaaaagcac    10215
 Pro Asp Gln 
3330

 tgattac                                                            10222




      <210> 250
      <211> 1260
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (5)..(1063)

      <400> 250
 gacc atg ccc agc ggc tgc cgc tgc ctg cat ctc gtg tgc ctg ttg tgc      49
      Met Pro Ser Gly Cys Arg Cys Leu His Leu Val Cys Leu Leu Cys
        1               5                  10                  15

 att ctg ggg gct ccc ggt cag cct gtc cga gcc gat gac tgc agc tcc       97
 Ile Leu Gly Ala Pro Gly Gln Pro Val Arg Ala Asp Asp Cys Ser Ser
                  20                  25                  30

 cac tgt gac ctg gcc cac ggc tgc tgt gca cct gac ggc tcc tgc agg      145
 His Cys Asp Leu Ala His Gly Cys Cys Ala Pro Asp Gly Ser Cys Arg
              35                  40                  45

 tgt gac ccg ggc tgg gag ggg ctg cac tgt gag cgc tgt gtg agg atg      193
 Cys Asp Pro Gly Trp Glu Gly Leu His Cys Glu Arg Cys Val Arg Met
          50                  55                  60

 cct ggc tgc cag cac ggt acc tgc cac cag cca tgg cag tgc atc tgc      241
 Pro Gly Cys Gln His Gly Thr Cys His Gln Pro Trp Gln Cys Ile Cys
      65                  70                  75

 cac agt ggc tgg gca ggc aag ttc tgt gac aaa ggc ttc cat ggg cgt      289
 His Ser Gly Trp Ala Gly Lys Phe Cys Asp Lys Gly Phe His Gly Arg
  80                  85                  90                  95

 gac tgc gag cgc aag gct gga ccc tgt gaa cag gca ggc tcc cca tgc      337
 Asp Cys Glu Arg Lys Ala Gly Pro Cys Glu Gln Ala Gly Ser Pro Cys
                 100                 105                 110

 cgc aat ggc ggg cag tgc cag gac gac cag ggc ttt gct ctc aac ttc      385
 Arg Asn Gly Gly Gln Cys Gln Asp Asp Gln Gly Phe Ala Leu Asn Phe
             115                 120                 125

 acg tgc cgc tgc ttg gtg ggc ttt gtg ggt gcc cgc tgt gag gta aat      433
 Thr Cys Arg Cys Leu Val Gly Phe Val Gly Ala Arg Cys Glu Val Asn
         130                 135                 140

 gtg gat gac tgc ctg atg cgg cct tgt gct aac ggt gcc acc tgc ctt      481
 Val Asp Asp Cys Leu Met Arg Pro Cys Ala Asn Gly Ala Thr Cys Leu
     145                 150                 155

 gac ggc ata aac cgc ttc tcc tgc ctc tgt cct gag ggc ttt gct gga      529
 Asp Gly Ile Asn Arg Phe Ser Cys Leu Cys Pro Glu Gly Phe Ala Gly
 160                 165                 170                 175

 cgc ttc tgc acc atc aac ctg gat gac tgt gcc agc cgc cca tgc cag      577
 Arg Phe Cys Thr Ile Asn Leu Asp Asp Cys Ala Ser Arg Pro Cys Gln
                 180                 185                 190

 aga ggg gcc cgc tgt cgg gac cgt gtc cac gac ttc gac tgc ctc tgc      625
 Arg Gly Ala Arg Cys Arg Asp Arg Val His Asp Phe Asp Cys Leu Cys
             195                 200                 205

 ccc agt ggc tat ggt ggc aag acc tgt gag ctt gtc tta cct gtc cca      673
 Pro Ser Gly Tyr Gly Gly Lys Thr Cys Glu Leu Val Leu Pro Val Pro
         210                 215                 220

 gac ccc cca acc aca gtg gac acc cct cta ggg ccc acc tca gct gta      721
 Asp Pro Pro Thr Thr Val Asp Thr Pro Leu Gly Pro Thr Ser Ala Val
     225                 230                 235

 gtg gta cct gcc acg ggg cca gcc ccc cac agc gca ggg gct ggt ctg      769
 Val Val Pro Ala Thr Gly Pro Ala Pro His Ser Ala Gly Ala Gly Leu
 240                 245                 250                 255

 ctg cgg atc tca gtg aag gag gtg gtg cgg agg caa gag gct ggg cta      817
 Leu Arg Ile Ser Val Lys Glu Val Val Arg Arg Gln Glu Ala Gly Leu
                 260                 265                 270

 ggt gag cct agc ttg gtg gcc ctg gtg gtg ttt ggg gcc ctc act gct      865
 Gly Glu Pro Ser Leu Val Ala Leu Val Val Phe Gly Ala Leu Thr Ala
             275                 280                 285

 gcc ctg gtt ctg gct act gtg ttg ctg acc ctg agg gcc tgg cgc cgg      913
 Ala Leu Val Leu Ala Thr Val Leu Leu Thr Leu Arg Ala Trp Arg Arg
         290                 295                 300

 ggt gtc tgc ccc cct gga ccc tgt tgc tac cct gcc cca cac tat gct      961
 Gly Val Cys Pro Pro Gly Pro Cys Cys Tyr Pro Ala Pro His Tyr Ala
     305                 310                 315

 cca gcg tgc cag gac cag gag tgt cag gtt agc atg ctg cca gca ggg     1009
 Pro Ala Cys Gln Asp Gln Glu Cys Gln Val Ser Met Leu Pro Ala Gly
 320                 325                 330                 335

 ctc ccc ctg cca cgt gac ttg ccc cct gag cct gga aag acc aca gca     1057
 Leu Pro Leu Pro Arg Asp Leu Pro Pro Glu Pro Gly Lys Thr Thr Ala
                 340                 345                 350

 ctg tga tggaggtggg ggctttctgg cccccttcct cacctcttcc acccctcaga      1113
 Leu 


 ctggagtggt ccgttctcac cacccttcag cttgggtaca cacacagagg agacctcagc   1173

 ctcacaccag aaatattatt tttttaatac acagaatgta agatggaatt ttatcaaata   1233

 aaactatgaa aatgcaaaaa aaaaaaa                                       1260




      <210> 251
      <211> 993
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (273)..(788)

      <400> 251
 tgcagatgcg aaggatctag gttgtggtct cctaatgaga atctaatgcc tctgaaagca     60

 ttccctccct gaccccattt ttcgtggaaa aattatcttc caccaaactg gtggccaaaa    120

 ggttgtggat gctgatatag aagacatgta aatgaaaaca ataaatggaa ttaaaaattt    180

 agagaaatgc tcagaaaaat gaaaactatt tgtgctccat taaagccatg catagataga    240

 atgtcttcat agaacctagg atccaaggtt ct  atg aag acc tca gct cat cca     293
                                      Met Lys Thr Ser Ala His Pro
                                        1               5

 ggc caa aag cat cct gat ttc tca atg ggc ctc ctc ttc cct cta ctg      341
 Gly Gln Lys His Pro Asp Phe Ser Met Gly Leu Leu Phe Pro Leu Leu
          10                  15                  20

 gca gcc cta gag gtg tgc agc tgt ggc tct tct gga tct cta gga tat      389
 Ala Ala Leu Glu Val Cys Ser Cys Gly Ser Ser Gly Ser Leu Gly Tyr
      25                  30                  35

 aac ctg cct cag aac cat ggc ctg cta ggc agg aac acc ttg gtg ctt      437
 Asn Leu Pro Gln Asn His Gly Leu Leu Gly Arg Asn Thr Leu Val Leu
  40                  45                  50                  55

 ttg ggc caa atg agg aga atc tct ccc ttc ttg tgt cta aag gac aga      485
 Leu Gly Gln Met Arg Arg Ile Ser Pro Phe Leu Cys Leu Lys Asp Arg
                  60                  65                  70

 agt gac ttc aga ttc ccc cag gag aag gtg gaa gtc agc cag ttg cag      533
 Ser Asp Phe Arg Phe Pro Gln Glu Lys Val Glu Val Ser Gln Leu Gln
              75                  80                  85

 aag gcc cag gct atg tct ttc ctc tat gat gtg tta cag cag gtc ttc      581
 Lys Ala Gln Ala Met Ser Phe Leu Tyr Asp Val Leu Gln Gln Val Phe
          90                  95                 100

 aac ttc tca cac aaa gcg ctc ctc tgc tgc atg gaa cat gac ctt cct      629
 Asn Phe Ser His Lys Ala Leu Leu Cys Cys Met Glu His Asp Leu Pro
     105                 110                 115

 gga cca act cca cac ttt atg tca tca gca gct gga aca cct gga gac      677
 Gly Pro Thr Pro His Phe Met Ser Ser Ala Ala Gly Thr Pro Gly Asp
 120                 125                 130                 135

 ctg ctt ggt gca gga gat ggg aga agg aga agc tgg ggg cag tgg gtg      725
 Leu Leu Gly Ala Gly Asp Gly Arg Arg Arg Ser Trp Gly Gln Trp Val
                 140                 145                 150

 att gag ggc tct aca ctg gcc ttg agg agg tat ttc cag gaa tcc atc      773
 Ile Glu Gly Ser Thr Leu Ala Leu Arg Arg Tyr Phe Gln Glu Ser Ile
             155                 160                 165

 tct acc ttg gaa tga atcctctgtc ctccagagtt tggttttgtg tccacaacac      828
 Ser Thr Leu Glu 
         170

 attctttgtc caatcagcat tgctatcgtg gaagttttga tttcactcaa ccacacggta    888

 tgaggaccag aaaccaagct cctcctggga ggccgccctg gtccccgaga ggggcgcgcg    948

 ggagtggacg ttcccgcacc ttcgccacga aatcgtcgca ccggg                    993




      <210> 252
      <211> 506
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (15)..(494)

      <400> 252
 gcccttgagc cgcc  atg gaa tac atg cca atg gaa atg tgt tcc ctc ccc      50
                  Met Glu Tyr Met Pro Met Glu Met Cys Ser Leu Pro
                    1               5                  10

 atg gca aga tac tac ata att aaa tat gca gac cag aag gct cta tac       98
 Met Ala Arg Tyr Tyr Ile Ile Lys Tyr Ala Asp Gln Lys Ala Leu Tyr
          15                  20                  25

 aca aga gac ggc cag ctg ctg gtg gga gat cct gtt gca gac aac tgc      146
 Thr Arg Asp Gly Gln Leu Leu Val Gly Asp Pro Val Ala Asp Asn Cys
      30                  35                  40

 tgt gca gag aag atc tgc aca ctt cct aac aga ggc ttg gac cgc acc      194
 Cys Ala Glu Lys Ile Cys Thr Leu Pro Asn Arg Gly Leu Asp Arg Thr
  45                  50                  55                  60

 aag gtc ccc att ttc ctg ggg atc cag gga ggg agc cgc tgc ctg gca      242
 Lys Val Pro Ile Phe Leu Gly Ile Gln Gly Gly Ser Arg Cys Leu Ala
                  65                  70                  75

 tgt gtg gag aca gaa gag ggg cct tcc cta cag ctg gag gat gtg aac      290
 Cys Val Glu Thr Glu Glu Gly Pro Ser Leu Gln Leu Glu Asp Val Asn
              80                  85                  90

 att gag gaa ctg tac aaa ggt ggt gaa gag gcc aca cgc ttc acc ttc      338
 Ile Glu Glu Leu Tyr Lys Gly Gly Glu Glu Ala Thr Arg Phe Thr Phe
          95                 100                 105

 ttc cag agc agc tca ggc tcc gcc ttc agg ctt gag gct gct gcc tgg      386
 Phe Gln Ser Ser Ser Gly Ser Ala Phe Arg Leu Glu Ala Ala Ala Trp
     110                 115                 120

 cct ggc tgg ttc ctg tgt ggc ccg gca gag ccc cag cag cca gta cag      434
 Pro Gly Trp Phe Leu Cys Gly Pro Ala Glu Pro Gln Gln Pro Val Gln
 125                 130                 135                 140

 ctc acc aag gag agt gag ccc tca gcc cgt acc aag ttt tac ttt gaa      482
 Leu Thr Lys Glu Ser Glu Pro Ser Ala Arg Thr Lys Phe Tyr Phe Glu
                 145                 150                 155

 cag agc tgg tag tgatcaagct tc                                        506
 Gln Ser Trp 






      <210> 253
      <211> 754
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (91)..(681)

      <400> 253
 gctcgccgag gcgccgagga gagcgggccg ccccacagcc cgagccggag agggacgcga     60

 gccgcgcgcc ccggtcgggc ctccgaaacc     atg aac ttt ctg ctg tct tgg     111
                                      Met Asn Phe Leu Leu Ser Trp
                                        1               5

 gtg cat tgg agc ctt gcc ttg ctg ctc tac ctc cac cat gcc aag tgg      159
 Val His Trp Ser Leu Ala Leu Leu Leu Tyr Leu His His Ala Lys Trp
          10                  15                  20

 tcc cag gct gca ccc atg gca gaa gga gga ggg cag aat cat cac gaa      207
 Ser Gln Ala Ala Pro Met Ala Glu Gly Gly Gly Gln Asn His His Glu
      25                  30                  35

 gtg gtg aag ttc atg gat gtc tat cag cgc agc tac tgc cat cca atc      255
 Val Val Lys Phe Met Asp Val Tyr Gln Arg Ser Tyr Cys His Pro Ile
  40                  45                  50                  55

 gag acc ctg gtg gac atc ttc cag gag tac cct gat gag atc gag tac      303
 Glu Thr Leu Val Asp Ile Phe Gln Glu Tyr Pro Asp Glu Ile Glu Tyr
                  60                  65                  70

 atc ttc aag cca tcc tgt gtg ccc ctg atg cga tgc ggg ggc tgc tgc      351
 Ile Phe Lys Pro Ser Cys Val Pro Leu Met Arg Cys Gly Gly Cys Cys
              75                  80                  85

 aat gac gag ggc ctg gag tgt gtg ccc act gag gag tcc aac atc acc      399
 Asn Asp Glu Gly Leu Glu Cys Val Pro Thr Glu Glu Ser Asn Ile Thr
          90                  95                 100

 atg cag att atg cgg atc aaa cct cac caa ggc cag cac ata gga gag      447
 Met Gln Ile Met Arg Ile Lys Pro His Gln Gly Gln His Ile Gly Glu
     105                 110                 115

 atg agc ttc cta cag cac aac aaa tgt gaa tgc aga cca aag aaa gat      495
 Met Ser Phe Leu Gln His Asn Lys Cys Glu Cys Arg Pro Lys Lys Asp
 120                 125                 130                 135

 aga gca aga caa gaa aaa aaa tca gtt cga gga aag gga aag ggg caa      543
 Arg Ala Arg Gln Glu Lys Lys Ser Val Arg Gly Lys Gly Lys Gly Gln
                 140                 145                 150

 aaa cga aag cgc aag aaa tcc cgg tat aag tcc tgg agc gtt ccc tgt      591
 Lys Arg Lys Arg Lys Lys Ser Arg Tyr Lys Ser Trp Ser Val Pro Cys
             155                 160                 165

 ggg cct tgc tca gag cgg aga aag cat ttg ttt gta caa gat ccg cag      639
 Gly Pro Cys Ser Glu Arg Arg Lys His Leu Phe Val Gln Asp Pro Gln
         170                 175                 180

 acg tgt tgt tcc tgc agc aga tgt gac aag ccg agg cgg tga gccgggc      688
 Thr Cys Cys Ser Cys Ser Arg Cys Asp Lys Pro Arg Arg 
     185                 190                 195

 aggaggaagg agcctccctc agggtttcgg gaaccagatc tctcaccacg gactgttacc    748

 gcgtcg                                                               754




      <210> 254
      <211> 608
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (43)..(516)

      <400> 254
 cagaattcgc ccttgtagga tccgatcgtg gaggatgatt aa   atg gtc ctg agt      54
                                                  Met Val Leu Ser
                                                    1

 ggg gcg ctg tgc ttc cga atg aag gac tcg gca ttg aag gtg ctt tat      102
 Gly Ala Leu Cys Phe Arg Met Lys Asp Ser Ala Leu Lys Val Leu Tyr
   5                  10                  15                  20

 ctg cat aat aac cag ctt cta gct gga ggg ctg cat gca ggg aag gtc      150
 Leu His Asn Asn Gln Leu Leu Ala Gly Gly Leu His Ala Gly Lys Val
                  25                  30                  35

 att aaa ggt gaa gag atc agc gtg gtc ccc aat cgg tgg ctg gat gcc      198
 Ile Lys Gly Glu Glu Ile Ser Val Val Pro Asn Arg Trp Leu Asp Ala
              40                  45                  50

 agc ctg tcc ccc gtc atc ctg ggt gtc cag ggt gga agc cag tgc ctg      246
 Ser Leu Ser Pro Val Ile Leu Gly Val Gln Gly Gly Ser Gln Cys Leu
          55                  60                  65

 tca tgt ggg gtg ggg cag gag ccg act cta aca cta gag cca gtg aac      294
 Ser Cys Gly Val Gly Gln Glu Pro Thr Leu Thr Leu Glu Pro Val Asn
      70                  75                  80

 atc atg gag ctc tat ctt ggt gcc aag gaa tcc aag agc ttc acc ttc      342
 Ile Met Glu Leu Tyr Leu Gly Ala Lys Glu Ser Lys Ser Phe Thr Phe
  85                  90                  95                 100

 tac cgg cgg gac atg ggg ctc acc tcc agc ttc gag tcg gct gcc tac      390
 Tyr Arg Arg Asp Met Gly Leu Thr Ser Ser Phe Glu Ser Ala Ala Tyr
                 105                 110                 115

 ccg ggc tgg ttc ctg tgc acg gtg cct gaa gcc gat cag cct gtc aga      438
 Pro Gly Trp Phe Leu Cys Thr Val Pro Glu Ala Asp Gln Pro Val Arg
             120                 125                 130

 ctc acc cag ctt ccc gag aat ggt ggc tgg aat gcc ccc atg aca ggc      486
 Leu Thr Gln Leu Pro Glu Asn Gly Gly Trp Asn Ala Pro Met Thr Gly
         135                 140                 145

 act ggc ttc cac cct gga cac cca gga tga c gggggacagg ctggcatcca      537
 Thr Gly Phe His Pro Gly His Pro Gly 
     150                 155

 gccaccgatt ggggaccacg ctgatctctt cacctttaat gaccttccct gcatgcagcc    597

 ctccaacgaa a                                                         608




      <210> 255
      <211> 1314
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (402)..(806)

      <220>
      <221> misc_feature
      <222> (1)...(1314)
      <223> n = a,t,c or g

      <400> 255
 ggccgacctg ttcttttccc tgacattgcc catcttggct gcctccaaga tgaatggctg     60

 gatttttggc acaatctgtg ccaggtggtc tagctcctga aggaagtcaa cttctacggt    120

 ggtattctac tactggcctg ccgcagcatg gactgttacc tggccattgt ccatgccaca    180

 cgcacactga cccagcagcg ccacttggtc aagttcatat gtctgggttt gtggaacctg    240

 ttcctgttac tgtccctacg catcttgctt ttccgaagga ccttctaccc atccaatgtt    300

 agcccagtct gctatgagga catgggcaac aatacagcaa actggtggat gctgttacgg    360

 atcctgcccc agtcctttgg cttcatcgtg ccgctgcgat c    atg ctg ttc tgc     413
                                                  Met Leu Phe Cys
                                                    1

 tac aga ttc acc ctg cat acg ctg ttt aag gcc cat atg ggg cag aag      461
 Tyr Arg Phe Thr Leu His Thr Leu Phe Lys Ala His Met Gly Gln Lys
   5                  10                  15                  20

 cac tgg acc atg tgg gtc atc ttt gct gtt gtc ctc att ttc ctg ctc      509
 His Trp Thr Met Trp Val Ile Phe Ala Val Val Leu Ile Phe Leu Leu
                  25                  30                  35

 tgc tgg ctg cct tac aac ctg gtc ctg ctg gca gac acc ctg gtg gga      557
 Cys Trp Leu Pro Tyr Asn Leu Val Leu Leu Ala Asp Thr Leu Val Gly
              40                  45                  50

 acc cag atg acc aat gag acc tgt gag cgc cgc aac gac atc aac cag      605
 Thr Gln Met Thr Asn Glu Thr Cys Glu Arg Arg Asn Asp Ile Asn Gln
          55                  60                  65

 gcc ctg gat gcc act gag att ctg ggc atc ctt cac agc tac ctc aat      653
 Ala Leu Asp Ala Thr Glu Ile Leu Gly Ile Leu His Ser Tyr Leu Asn
      70                  75                  80

 ccc ctc atc tac gcc ttc att ggc cag aag ttt tgc cat gga ctt ctc      701
 Pro Leu Ile Tyr Ala Phe Ile Gly Gln Lys Phe Cys His Gly Leu Leu
  85                  90                  95                 100

 aag att ata gcc ata cat ggc ttg atc agc aag gac tcc ctg ccc aaa      749
 Lys Ile Ile Ala Ile His Gly Leu Ile Ser Lys Asp Ser Leu Pro Lys
                 105                 110                 115

 gac agc agg cct tcc ttt gtt ggc tct tct tca ggg cac act tcc act      797
 Asp Ser Arg Pro Ser Phe Val Gly Ser Ser Ser Gly His Thr Ser Thr
             120                 125                 130

 act ctc taa gacctct tgcctaagtg cagccccgtg gggttcctcc cttctcttca      853
 Thr Leu 


 cagtcacatt ccaagcctca tgtccactag ctcttcttgg tctcagtgtc agtgcagccc    913

 ccactgtggt cgcaggaagc agaggaggcc acgttcttac tagtttccct tgcatgattt    973

 agaaagcctg ccctggtacc tcaccccttg ccataattac tacatcactt gctggagctc   1033

 tgtccctcct gcccttgagc tcatggcact ctatgttcta agaagtgaaa atctacactc   1093

 cagtgagagn nnnntgcata ctcattagga tggttatcgc cagaagaaaa gaaatcataa   1153

 ataaggcact gggccaccaa ggggccgcgg gggtccacgc cccgcgcccc cagggngggg   1213

 ggntgggaaa attttttgtn ccttggggga aaacaaaaag gnanatttgc taaaagaagg   1273

 gggcgaagga gtcccccctt tgccttcccc ctccactttg g                       1314




      <210> 256
      <211> 985
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (83)..(931)

      <400> 256
 aattcgcggc cgcgtcgact acgagaagac gacagaaggg tacggctgcg agaagacgac     60

 agaagggggt gacacagcga ag atg gcg tcg ccc ggc tgc ctg tgg ctc ttg     112
                          Met Ala Ser Pro Gly Cys Leu Trp Leu Leu
                            1               5                  10

 gct gtg gct ctc ctg cca tgg acc tgc gct tct cgg gcg ctg cag cat      160
 Ala Val Ala Leu Leu Pro Trp Thr Cys Ala Ser Arg Ala Leu Gln His
                  15                  20                  25

 ctg gac ccg ccg gcg ccg ctg ccg ttg gtg atc tgg cat ggg atg gga      208
 Leu Asp Pro Pro Ala Pro Leu Pro Leu Val Ile Trp His Gly Met Gly
              30                  35                  40

 gac agc tgt tgc aat ccc tta agc atg ggt gct att aaa aaa atg gtg      256
 Asp Ser Cys Cys Asn Pro Leu Ser Met Gly Ala Ile Lys Lys Met Val
          45                  50                  55

 gag aag aaa ata cct gga att tac gtc tta tct tta gag att ggg aag      304
 Glu Lys Lys Ile Pro Gly Ile Tyr Val Leu Ser Leu Glu Ile Gly Lys
      60                  65                  70

 acc ctg atg gag gac gtg gag aac agc ttc ttc ttg aat gtc aat tcc      352
 Thr Leu Met Glu Asp Val Glu Asn Ser Phe Phe Leu Asn Val Asn Ser
  75                  80                  85                  90

 caa gta aca aca gtg tgt cag gca ctt gct aag gat cct aaa ttg cag      400
 Gln Val Thr Thr Val Cys Gln Ala Leu Ala Lys Asp Pro Lys Leu Gln
                  95                 100                 105

 caa ggc tac aat gct atg gga ttc tcc cag gga ggc caa ttt ctg agg      448
 Gln Gly Tyr Asn Ala Met Gly Phe Ser Gln Gly Gly Gln Phe Leu Arg
             110                 115                 120

 gca gtg gct cag aga tgc cct tca cct ccc atg atc aat ctg atc tcg      496
 Ala Val Ala Gln Arg Cys Pro Ser Pro Pro Met Ile Asn Leu Ile Ser
         125                 130                 135

 gtt ggg gga caa cat caa ggt gtt ttt gga ctc cct cga tgc cca gga      544
 Val Gly Gly Gln His Gln Gly Val Phe Gly Leu Pro Arg Cys Pro Gly
     140                 145                 150

 gag agc tct cac atc tgt gac ttc atc cga aaa aca ctg aat gct ggg      592
 Glu Ser Ser His Ile Cys Asp Phe Ile Arg Lys Thr Leu Asn Ala Gly
 155                 160                 165                 170

 gcg tac tcc aaa gtt gtt cag gaa cgc ctc gtg caa gcc gaa tac tgg      640
 Ala Tyr Ser Lys Val Val Gln Glu Arg Leu Val Gln Ala Glu Tyr Trp
                 175                 180                 185

 cat gac ccc ata aag gag gat gtg tat cgc aac cac agc atc ttc ttg      688
 His Asp Pro Ile Lys Glu Asp Val Tyr Arg Asn His Ser Ile Phe Leu
             190                 195                 200

 gca gat ata aat cag gag cgg ggt atc aat gag tcc tac aag aaa aac      736
 Ala Asp Ile Asn Gln Glu Arg Gly Ile Asn Glu Ser Tyr Lys Lys Asn
         205                 210                 215

 ctg atg gcc ctg aag aag ttt gtg atg gtg aaa ttc ctc aat gat tcc      784
 Leu Met Ala Leu Lys Lys Phe Val Met Val Lys Phe Leu Asn Asp Ser
     220                 225                 230

 att gtg gac cct gta gat tcg gag gac cgc ctg ggg cta aag gaa atg      832
 Ile Val Asp Pro Val Asp Ser Glu Asp Arg Leu Gly Leu Lys Glu Met
 235                 240                 245                 250

 gac aat gca gga cag cta gtg ttt ctg gct aca gaa ggg gac cat ctt      880
 Asp Asn Ala Gly Gln Leu Val Phe Leu Ala Thr Glu Gly Asp His Leu
                 255                 260                 265

 cag ttg tct gaa gaa tgg ttt tat gcc cac atc ata cca ttc ctt gga      928
 Gln Leu Ser Glu Glu Trp Phe Tyr Ala His Ile Ile Pro Phe Leu Gly
             270                 275                 280

 tga aacc cgtatagttc acaatagagc tcagggagcc cctaactctt ccaaaccaca      985
 






      <210> 257
      <211> 1257
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (1)..(1257)

      <400> 257
  atg ccg tct tct gtc tcg tgg ggc atc ctc ctg ctg gca ggc ctg tgc      48
  Met Pro Ser Ser Val Ser Trp Gly Ile Leu Leu Leu Ala Gly Leu Cys
    1               5                  10                  15

 tgc ctg gtc cct gtc tcc ctg gct gag gat ccc cag gga gat gct gcc       96
 Cys Leu Val Pro Val Ser Leu Ala Glu Asp Pro Gln Gly Asp Ala Ala
              20                  25                  30

 cag aag aca gat aca tcc cac cat gat cag gat cac cca acc ttc aac      144
 Gln Lys Thr Asp Thr Ser His His Asp Gln Asp His Pro Thr Phe Asn
          35                  40                  45

 aag atc acc ccc aac ctg gct gag ttc gcc ttc agc cta tac cgc cag      192
 Lys Ile Thr Pro Asn Leu Ala Glu Phe Ala Phe Ser Leu Tyr Arg Gln
      50                  55                  60

 ctg gca cac cag tcc aac agc acc aat atc ttc ttc tcc cca gtg agc      240
 Leu Ala His Gln Ser Asn Ser Thr Asn Ile Phe Phe Ser Pro Val Ser
  65                  70                  75                  80

 atc gct aca gcc ttt gca atg ctc tcc ctg ggg acc aag gct gac act      288
 Ile Ala Thr Ala Phe Ala Met Leu Ser Leu Gly Thr Lys Ala Asp Thr
                  85                  90                  95

 cgc aca gag atc ctg gaa ggc ctg aat gtc aac ctc aca gag acg cct      336
 Arg Thr Glu Ile Leu Glu Gly Leu Asn Val Asn Leu Thr Glu Thr Pro
             100                 105                 110

 gag gcc aag atc cac gaa tgc ttc cag caa gtt ctc caa gcc ctc agc      384
 Glu Ala Lys Ile His Glu Cys Phe Gln Gln Val Leu Gln Ala Leu Ser
         115                 120                 125

 agg cca gac acc cgg ctc cag ctg acc acc ggc agt agc ctg ttt gtt      432
 Arg Pro Asp Thr Arg Leu Gln Leu Thr Thr Gly Ser Ser Leu Phe Val
     130                 135                 140

 aac aag agt atg aag cta gtg gac acg ttt ttg gag gat acc aag aag      480
 Asn Lys Ser Met Lys Leu Val Asp Thr Phe Leu Glu Asp Thr Lys Lys
 145                 150                 155                 160

 ctg tac cac tca gaa gcc tct tcc atc aac ttc agg gac acc gag gag      528
 Leu Tyr His Ser Glu Ala Ser Ser Ile Asn Phe Arg Asp Thr Glu Glu
                 165                 170                 175

 gcc aaa gag cag atc aac aat tat gtg gag aaa aga act gga aga aaa      576
 Ala Lys Glu Gln Ile Asn Asn Tyr Val Glu Lys Arg Thr Gly Arg Lys
             180                 185                 190

 gta gtg gat ttg gtc aaa cac ctg aaa aaa gac aca agt ctt gcc ctg      624
 Val Val Asp Leu Val Lys His Leu Lys Lys Asp Thr Ser Leu Ala Leu
         195                 200                 205

 gtg gat tac att tcc ttt cac ggc aag tgg aaa gat aaa ttc aag gct      672
 Val Asp Tyr Ile Ser Phe His Gly Lys Trp Lys Asp Lys Phe Lys Ala
     210                 215                 220

 gag cgc att atg gta gag ggc ttc cat gtg gat gat aag acc atc atc      720
 Glu Arg Ile Met Val Glu Gly Phe His Val Asp Asp Lys Thr Ile Ile
 225                 230                 235                 240

 aga gtg cct atg ata aac cac ctg ggt aga ttt gac atc cac cgg gac      768
 Arg Val Pro Met Ile Asn His Leu Gly Arg Phe Asp Ile His Arg Asp
                 245                 250                 255

 agg gag tta tcc agc tgg gtg ctg gca cag cac tat gtg ggg aac gcc      816
 Arg Glu Leu Ser Ser Trp Val Leu Ala Gln His Tyr Val Gly Asn Ala
             260                 265                 270

 act gcc ttc ttc atc ctg ccc gat cca aag aag atg tgg cag ttg gaa      864
 Thr Ala Phe Phe Ile Leu Pro Asp Pro Lys Lys Met Trp Gln Leu Glu
         275                 280                 285

 gaa aaa ttg acc tac agc cac ctt gaa aat atc cag aga gcc ttt gac      912
 Glu Lys Leu Thr Tyr Ser His Leu Glu Asn Ile Gln Arg Ala Phe Asp
     290                 295                 300

 ata agg tct atc aat cta cat ttt ccc aaa ctg tcc att tct gga acc      960
 Ile Arg Ser Ile Asn Leu His Phe Pro Lys Leu Ser Ile Ser Gly Thr
 305                 310                 315                 320

 tac aaa ctc aag aga gtc cct agg aat ctg ggc atc acc aag atc ttc     1008
 Tyr Lys Leu Lys Arg Val Pro Arg Asn Leu Gly Ile Thr Lys Ile Phe
                 325                 330                 335

 agc aac gag gcc gac ctc tct gga gtc agt cag gag gca ccc ctg aag     1056
 Ser Asn Glu Ala Asp Leu Ser Gly Val Ser Gln Glu Ala Pro Leu Lys
             340                 345                 350

 ctc tcc aag gct gtg cat gtg gct gtg ctc acc att gat gag aaa ggg     1104
 Leu Ser Lys Ala Val His Val Ala Val Leu Thr Ile Asp Glu Lys Gly
         355                 360                 365

 acc gaa gcc acc gga gcc ccc cat ctg gag gag aag gcc tgg tct aag     1152
 Thr Glu Ala Thr Gly Ala Pro His Leu Glu Glu Lys Ala Trp Ser Lys
     370                 375                 380

 tat cag aca gtc atg ttc aac cga ccc ttc ctg gtc atc atc aag gag     1200
 Tyr Gln Thr Val Met Phe Asn Arg Pro Phe Leu Val Ile Ile Lys Glu
 385                 390                 395                 400

 tac atc acc aac ttt ccg ctc ttc att gga aaa gtg gtg aat ccc acc     1248
 Tyr Ile Thr Asn Phe Pro Leu Phe Ile Gly Lys Val Val Asn Pro Thr
                 405                 410                 415

 caa aaa taa                                                         1257
 Gln Lys 






      <210> 258
      <211> 641
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (131)..(334)

      <400> 258
 tactactact aaattcgcgg cgctcgactt tttttttttt ttttaaagga aagaaaggag     60

 gataaagcag cagtaggaag tttcaacaag caagacagct ggttgcaggg gatgtgcact    120

 agtcatatca   atg ctc tgc att atc ttt cct cag ggg ctc ttc aca agg     169
              Met Leu Cys Ile Ile Phe Pro Gln Gly Leu Phe Thr Arg
                1               5                  10

 gct tta ctg aga acc tgc tca gct ctt cta cat gct gac tgg cct gaa      217
 Ala Leu Leu Arg Thr Cys Ser Ala Leu Leu His Ala Asp Trp Pro Glu
      15                  20                  25

 atc tct ttt gtg gtg gtg gtg gtg ttt ttt aag acg gaa tct tgc tct      265
 Ile Ser Phe Val Val Val Val Val Phe Phe Lys Thr Glu Ser Cys Ser
  30                  35                  40                  45

 gtt gcc cag gat gga gtg cag tgg tgc gat ctc agg tca ctg aaa cct      313
 Val Ala Gln Asp Gly Val Gln Trp Cys Asp Leu Arg Ser Leu Lys Pro
                  50                  55                  60

 cca cct ccc agg ttc aag tga tt ctcctgcctc agcctcccca gtagcaaaga      366
 Pro Pro Pro Arg Phe Lys 
              65

 ttaccggcat gcaccaccac gcccggcatg gcctgaaatc ttgactgcta agttacactt    426

 tcagccacta atttacattc tcagttatac tgccacgggc cagattttca aatatttccc    486

 tgcaatgtgt tgcattttac caatatcgta caggccattc ctacaaaata ccgggttttc    546

 tactctgaat aagctattga tgcctaacca aaatggtggg ctccttcttt tagagagtgg    606

 ggaacccaag ggaagtttct aattcttgat ctggg                               641




      <210> 259
      <211> 826
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (332)..(727)

      <400> 259
 gggggcttaa aaaaagagtt gtttatttgg ggggcaagaa aatttttttt tggggcccta     60

 aaaaaaaaaa aaaaaccccc cccccccggc ggaaaaaaat tgtttttttc aaaggggggg    120

 ccgccttttt tttcctcccc ggataaaaac tatatttttt tttttttcct tttttatccg    180

 tgagcctgga tgctttggag ccaagctttc gtcccatgca agggaaacaa ccacttctgg    240

 gatgtccgct gcaatctgct ccggggctgc agcaacctca tcagctcttg cctggagtgg    300

 ctcagcctgg gcctgcaggg ccaccaggag a   atg gca gca agg atg gca agg     352
                                      Met Ala Ala Arg Met Ala Arg
                                        1               5

 gtg ctc ctt gct ata gaa gac ctg gga cag agg act gct gtc tgc cct      400
 Val Leu Leu Ala Ile Glu Asp Leu Gly Gln Arg Thr Ala Val Cys Pro
          10                  15                  20

 ctc tgg tca ccc tgc cta gct aga gga tct gtg acc cca gcc atg agg      448
 Leu Trp Ser Pro Cys Leu Ala Arg Gly Ser Val Thr Pro Ala Met Arg
      25                  30                  35

 acc ctc gcc atc ctt gct gcc att ctc ctg gtg gcc ctg cag gcc cag      496
 Thr Leu Ala Ile Leu Ala Ala Ile Leu Leu Val Ala Leu Gln Ala Gln
  40                  45                  50                  55

 gct gag cca ctc cag gca aga gct gat gag gtt gct gca gcc ccg gag      544
 Ala Glu Pro Leu Gln Ala Arg Ala Asp Glu Val Ala Ala Ala Pro Glu
                  60                  65                  70

 cag att gca gcg gac atc cca gaa gtg gtt gtt tcc ctt gca tgg gac      592
 Gln Ile Ala Ala Asp Ile Pro Glu Val Val Val Ser Leu Ala Trp Asp
              75                  80                  85

 gaa agc ttg gct cca aag cat cca ggc tca agg aaa aac atg gcc tgc      640
 Glu Ser Leu Ala Pro Lys His Pro Gly Ser Arg Lys Asn Met Ala Cys
          90                  95                 100

 tat tgc aga ata cca gcg tgc att gca gga gaa cgt cgc tat gga acc      688
 Tyr Cys Arg Ile Pro Ala Cys Ile Ala Gly Glu Arg Arg Tyr Gly Thr
     105                 110                 115

 tgc atc tac cag gga aga ctc tgg gca ttc tgc tgc tga gcttgcagaa       737
 Cys Ile Tyr Gln Gly Arg Leu Trp Ala Phe Cys Cys 
 120                 125                 130

 aaagaaaaat gagctcaaaa tttgctttga gagctacagg gaaatgttat tactcctgta    797

 ccttctgctc aatttccctt cctcgtccc                                      826




      <210> 260
      <211> 1070
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (342)..(572)

      <400> 260
 ctcttgagag cactcagctg gaactgagcc gctgcaactg gcagtaggtc aggatgagaa     60

 atgatgacgt cctcctcctc caaggaggaa agccttccct cccccaggag ctggagctct    120

 tgaaggcaag attttgtcat ccactgaatt ttaagatctc gtaatgcttc agtaaactct    180

 tcttttaaat ctttctcttt ttctgaatct ttttccttat ctttgctgcc attcttagtc    240

 tttgttggtg gaggtattaa gtagtaatga acagggatta catctgagtc caaccaacag    300

 gacttactga gtccccgcga tgtgccaggt aatggtgaaa c    atg aga ctg gga     353
                                                  Met Arg Leu Gly
                                                    1

 aaa gga aac agg tct act gct tgg gct agc tct ttc agg acc cag ctg      401
 Lys Gly Asn Arg Ser Thr Ala Trp Ala Ser Ser Phe Arg Thr Gln Leu
   5                  10                  15                  20

 cct gtc ctg ctc ctc tcc ttc ttg agg ttc act ctc tgg gta ggc act      449
 Pro Val Leu Leu Leu Ser Phe Leu Arg Phe Thr Leu Trp Val Gly Thr
                  25                  30                  35

 gcc ctg agc aaa gcc aag gta agc gca aaa tct gag ctg atc ttc tac      497
 Ala Leu Ser Lys Ala Lys Val Ser Ala Lys Ser Glu Leu Ile Phe Tyr
              40                  45                  50

 cac caa gtt ctt atg gaa aca gac tgc atc agt gtc atc tgt aca gca      545
 His Gln Val Leu Met Glu Thr Asp Cys Ile Ser Val Ile Cys Thr Ala
          55                  60                  65

 aag aca aca cat agc ttt ctt tcc tag ttcag tctttgacaa tgttaaggat      597
 Lys Thr Thr His Ser Phe Leu Ser 
      70                  75

 cctgcaagat agcatccagg tcctgcccct ttaggtattt tatcatcagg taaggaagta    657

 acaaagaatg gctggttata tttgggtggt aatgtcaaat tgcttgattt cttcttccct    717

 agaagtgcaa aactatgatt ttcatgaata tctaagctca aggtattaga caatctatga    777

 gaaacaataa atggaaggtc tttaaggcgt tccaaatcac tgatttgctc atggcgaatc    837

 tgtagtcgaa ttgtataatc tcctttctcc agtttcaaag aataaatgtt taactgagga    897

 gcagtacaca ctatcccatg gaaagaaatg gtataatcaa tgttgacatc actgagactt    957

 gcccaccaac gagcaatgca aaattcaatt gcttttccac ctgaaaacac aaaggagcgc   1017

 actgaaggaa gaacatcagt actttcacct tctatggaag aaagactagt cat          1070




      <210> 261
      <211> 3118
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (1)..(1527)

      <400> 261
  atg ccc cgc cca gac ctt gcc cct gct ctg ttg gtg gca gtt ctt gta      48
  Met Pro Arg Pro Asp Leu Ala Pro Ala Leu Leu Val Ala Val Leu Val
    1               5                  10                  15

 ctc ctg tac ttg ctt gta tct gca gca gct cct gct cct tcc tcg gac       96
 Leu Leu Tyr Leu Leu Val Ser Ala Ala Ala Pro Ala Pro Ser Ser Asp
              20                  25                  30

 tcc act cca gaa aat gtg tgc cca gtc gaa acc act acc aat ttc atc      144
 Ser Thr Pro Glu Asn Val Cys Pro Val Glu Thr Thr Thr Asn Phe Ile
          35                  40                  45

 tgg gag ctt tct tca ccc cac aac act tcc gca gtt ctg ctg gtt gtc      192
 Trp Glu Leu Ser Ser Pro His Asn Thr Ser Ala Val Leu Leu Val Val
      50                  55                  60

 ttc cac aag ggc ccc agc tgc aga aac tca ggg ttc aaa cca tta aat      240
 Phe His Lys Gly Pro Ser Cys Arg Asn Ser Gly Phe Lys Pro Leu Asn
  65                  70                  75                  80

 gat gag aaa gct aga agt gtt ttc tat ttg atc agt ttt tcc ccc cgc      288
 Asp Glu Lys Ala Arg Ser Val Phe Tyr Leu Ile Ser Phe Ser Pro Arg
                  85                  90                  95

 ctt tgt tca gta aac gat tat gag gga aat gac tct gaa gca gaa gac      336
 Leu Cys Ser Val Asn Asp Tyr Glu Gly Asn Asp Ser Glu Ala Glu Asp
             100                 105                 110

 ctg aat ttc agg gag gct ttg cct tca tca agt cag gaa aac aca cct      384
 Leu Asn Phe Arg Glu Ala Leu Pro Ser Ser Ser Gln Glu Asn Thr Pro
         115                 120                 125

 aga tca aag gtt ttt gaa aat aaa gtt aat tca gag aag gta aaa ctt      432
 Arg Ser Lys Val Phe Glu Asn Lys Val Asn Ser Glu Lys Val Lys Leu
     130                 135                 140

 tct ctt cgg aat ttc cca cat aat gat tat gag gat gtt ttt gaa gag      480
 Ser Leu Arg Asn Phe Pro His Asn Asp Tyr Glu Asp Val Phe Glu Glu
 145                 150                 155                 160

 cct tca gaa agt ggc agt gat ccc agc atg tgg aca gcc aga ggc ccc      528
 Pro Ser Glu Ser Gly Ser Asp Pro Ser Met Trp Thr Ala Arg Gly Pro
                 165                 170                 175

 ttc aga aga gac agg tgg agc agt gag gat gag gag gct gca ggg cca      576
 Phe Arg Arg Asp Arg Trp Ser Ser Glu Asp Glu Glu Ala Ala Gly Pro
             180                 185                 190

 tca cag gct ctc tcc cct cta ctt tct gat acg cgc aaa att gtt tct      624
 Ser Gln Ala Leu Ser Pro Leu Leu Ser Asp Thr Arg Lys Ile Val Ser
         195                 200                 205

 gaa gga gaa cta gat cag ttg gct cag att cgg cca tta ata ttc aat      672
 Glu Gly Glu Leu Asp Gln Leu Ala Gln Ile Arg Pro Leu Ile Phe Asn
     210                 215                 220

 ttt cat gag cag aca gcc atc aag gat tgt ttg aaa atc ctt gag gaa      720
 Phe His Glu Gln Thr Ala Ile Lys Asp Cys Leu Lys Ile Leu Glu Glu
 225                 230                 235                 240

 aaa aca gca gcg tat gat atc atg cag gaa ttt atg gct tta gaa ctt      768
 Lys Thr Ala Ala Tyr Asp Ile Met Gln Glu Phe Met Ala Leu Glu Leu
                 245                 250                 255

 aag aat ctg cct ggt gag ttc tac tct ggg aat caa cca agc aac aga      816
 Lys Asn Leu Pro Gly Glu Phe Tyr Ser Gly Asn Gln Pro Ser Asn Arg
             260                 265                 270

 gaa aaa aac aga tac cga gat att ctt cca tat gat tca aca cgc gtt      864
 Glu Lys Asn Arg Tyr Arg Asp Ile Leu Pro Tyr Asp Ser Thr Arg Val
         275                 280                 285

 cct ctt gga aaa agc aag gac tac atc aat gct agt tat att aga ata      912
 Pro Leu Gly Lys Ser Lys Asp Tyr Ile Asn Ala Ser Tyr Ile Arg Ile
     290                 295                 300

 gtc aat tgt gga gaa gag tat ttt tat atc gct act caa gga cca ctg      960
 Val Asn Cys Gly Glu Glu Tyr Phe Tyr Ile Ala Thr Gln Gly Pro Leu
 305                 310                 315                 320

 ctg agc acc ata gat gac ttt tgg caa atg gtg ttg gaa aat aat tca     1008
 Leu Ser Thr Ile Asp Asp Phe Trp Gln Met Val Leu Glu Asn Asn Ser
                 325                 330                 335

 aat gtt att gcc atg ata acc aga gag atg gaa ggt gga att atc aaa     1056
 Asn Val Ile Ala Met Ile Thr Arg Glu Met Glu Gly Gly Ile Ile Lys
             340                 345                 350

 tgc tac cat tac tgg ccc att tct ctg aag aag cca ttg gaa ttg aaa     1104
 Cys Tyr His Tyr Trp Pro Ile Ser Leu Lys Lys Pro Leu Glu Leu Lys
         355                 360                 365

 cac ttc cgt gta ttc ctg gag aac tac cag ata ctt caa tat ttc atc     1152
 His Phe Arg Val Phe Leu Glu Asn Tyr Gln Ile Leu Gln Tyr Phe Ile
     370                 375                 380

 att cga atg ttt caa gtt gtg gag aag tcc acg gga act agt cac tct     1200
 Ile Arg Met Phe Gln Val Val Glu Lys Ser Thr Gly Thr Ser His Ser
 385                 390                 395                 400

 gta aaa cag ttg cag ttc acc aag tgg cca gac cat ggc act cct gcc     1248
 Val Lys Gln Leu Gln Phe Thr Lys Trp Pro Asp His Gly Thr Pro Ala
                 405                 410                 415

 tca gca gat agc ttc ata aaa tat att cgt tat gca agg aag agc cac     1296
 Ser Ala Asp Ser Phe Ile Lys Tyr Ile Arg Tyr Ala Arg Lys Ser His
             420                 425                 430

 ctt aca gga ccc atg gtt gtt cac tgc agt gcc ggc ata ggc cgg aca     1344
 Leu Thr Gly Pro Met Val Val His Cys Ser Ala Gly Ile Gly Arg Thr
         435                 440                 445

 ggg gtg ttc cta tgt gtg gat gtc gtg ttc tgt gcc atc gta aag gac     1392
 Gly Val Phe Leu Cys Val Asp Val Val Phe Cys Ala Ile Val Lys Asp
     450                 455                 460

 tgt tca ttc aac atc atg gat ata gtg gcc caa atg aga gaa caa cgt     1440
 Cys Ser Phe Asn Ile Met Asp Ile Val Ala Gln Met Arg Glu Gln Arg
 465                 470                 475                 480

 tct ggc atg gtt caa acg aag gag cag tat cac ttt tgt tac gat att     1488
 Ser Gly Met Val Gln Thr Lys Glu Gln Tyr His Phe Cys Tyr Asp Ile
                 485                 490                 495

 gtg ctt gaa gtt ctt cgg aaa ctt ctg act ttg gat taa gaaagacttc      1537
 Val Leu Glu Val Leu Arg Lys Leu Leu Thr Leu Asp 
             500                 505

 tgttgcctct cacttgaaat taccaagtgg gtttgcacct cctcataaag aacatgtttg   1597

 cactgtgctg aagggctttg ctatgcatac aatctgcttt cttggtttat cagtttattt   1657

 tctttctaaa agctccctga agggcaatat catttggctt ggggtgatca gtgtttactt   1717

 attgatcttg ctagacaata tcaaaataac ttcccacatt ttccagtgaa acagatgtta   1777

 cataaaacga ttgcagcttg gctatttggt tgaagggatt acagagccca ataaaggatt   1837

 taaaatatat tcattaagat tttatttgga aaggtggctg gagagagctg aggatttcca   1897

 ggactttgta agttcttatt ctgggagaac ataaggccaa taatcatgac ctcttccagg   1957

 catttttaag acagatgtct attcatgttc tttagctaga gcctgtactt tttgctggca   2017

 tttgaataac ccagtttaaa aagagtccag ttagggtgga ctaactttgg acacaaattg   2077

 gcttccattt cctacatttt catactgctg ccttcctaca gctgctagac caagacctgt   2137

 tggtctggga agcatttcat ggatagggag agctcctctc ggtgaacagt ccaaaactaa   2197

 aatagatgtt tatatagaaa gcccaagagg agacttttgc catgcctgag ttctttccta   2257

 tcccacccta acacttaaca tattacttag tctgctttgt taaaagcaag tattaccttt   2317

 aacttgcctc ttactctttg ccctttagct aactaataaa gtttgatata ggcattatta   2377

 tataattctg agtcattcat ggtatctctc atgtttgatg tatttttcaa actaagatct   2437

 atgatagttt ttttttccag agttccatta aatcatttat ttcctttact ttctcacctc   2497

 tgttgaaaca tttagaaact ggatttggga acccaatttt ggaaaaccag attcatagtc   2557

 atgaaaatgg aaacttccat attctgtttt tgaaaagatg tggccattat tacagtaatt   2617

 ttattatagg actttgcctc gtacaattaa tagtgatatt ttggacaagg agttctggtg   2677

 acaagctata cctaattata agctataaaa caatagatat gagtgtttgt acagtttaac   2737

 tcaatggaga tcagaatatt ctatgtattg agaaaatgtt taatatcaat ctataaatct   2797

 tgaatttcta agaggcttat tttgttcttt tggctgaatg agtatatttg aattggttga   2857

 ataattaata attctcattg taaaaataat tatatgccaa aaatatattt gatgttaaat   2917

 caaatagatg attctgttta cattgttcat atgaataata atctgtgtta atttcatttt   2977

 gataattggc ctttaatatt tgtatctcta attttatttt ttctctgtta ctgtaaaata   3037

 atagctataa tgtataacaa ttttcttcag aagaattcta tgctattatt aaaataaaat   3097

 atttactgtg taaaaaaaaa a                                             3118




      <210> 262
      <211> 754
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (148)..(732)

      <400> 262
 cccacgaggg gacgcggccg aggagggtcg ctgtccaccc gggggcgtgg gagtgaggta     60

 ccagattcag cccatttggc cccgacgcct ctgttctcgg aatccgggtg ctgcggattg    120

 aggtcccggt tcctaacgga ctgcaag    atg gag gaa ggc ggg aac cta gga     171
                                  Met Glu Glu Gly Gly Asn Leu Gly
                                    1               5

 ggc ctg att aag atg gtc cat cta ctg gtc ttg tca ggt gcc tgg ggc      219
 Gly Leu Ile Lys Met Val His Leu Leu Val Leu Ser Gly Ala Trp Gly
      10                  15                  20

 atg caa atg tgg gtg acc ttc gtc tca ggc ttc ctg ctt ttc cga agc      267
 Met Gln Met Trp Val Thr Phe Val Ser Gly Phe Leu Leu Phe Arg Ser
  25                  30                  35                  40

 ctt ccc cga cat acc ttc gga cta gtg cag agc aaa ctc ttc ccc ttc      315
 Leu Pro Arg His Thr Phe Gly Leu Val Gln Ser Lys Leu Phe Pro Phe
                  45                  50                  55

 tac ttc cac atc tcc atg ggc tgt gcc ttc atc aac ctc tgc atc ttg      363
 Tyr Phe His Ile Ser Met Gly Cys Ala Phe Ile Asn Leu Cys Ile Leu
              60                  65                  70

 gct tca cag cat gct tgg gct cag ctc aca ttc tgg gag gcc agc cag      411
 Ala Ser Gln His Ala Trp Ala Gln Leu Thr Phe Trp Glu Ala Ser Gln
          75                  80                  85

 ctt tac ctg ctg ttc ctg agc ctt acg ctg gcc act gtc aac gcc cgc      459
 Leu Tyr Leu Leu Phe Leu Ser Leu Thr Leu Ala Thr Val Asn Ala Arg
      90                  95                 100

 tgg ctg gaa ccc cgc acc aca gct gcc atg tgg gcc ctg caa acc gtg      507
 Trp Leu Glu Pro Arg Thr Thr Ala Ala Met Trp Ala Leu Gln Thr Val
 105                 110                 115                 120

 gag aag gag cga ggc ctg ggt ggg gag gta cca ggc agc cac cag ggt      555
 Glu Lys Glu Arg Gly Leu Gly Gly Glu Val Pro Gly Ser His Gln Gly
                 125                 130                 135

 ccc gat ccc tac cgc cag ctg cga gag aag gac ccc aag tac agt gct      603
 Pro Asp Pro Tyr Arg Gln Leu Arg Glu Lys Asp Pro Lys Tyr Ser Ala
             140                 145                 150

 ctc cgc aca gaa ttt ctt ccg cta cat ggg ctg tcc tct ctt tgc aat      651
 Leu Arg Thr Glu Phe Leu Pro Leu His Gly Leu Ser Ser Leu Cys Asn
         155                 160                 165

 ctg ggc tgc gtc ctg agc aat ggg ctc tgt ctc gct ggc ttg ccc tgg      699
 Leu Gly Cys Val Leu Ser Asn Gly Leu Cys Leu Ala Gly Leu Pro Trp
     170                 175                 180

 gaa tta gga gct cta gct ggg cct ggt gta taa tgctctcc gaaaaaaaaa      750
 Glu Leu Gly Ala Leu Ala Gly Pro Gly Val 
 185                 190

 aaaa                                                                 754




      <210> 263
      <211> 923
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (306)..(464)

      <400> 263
 ctgcctttgg ctgtaccact tcccttttct tctcgcctgc acctccctca tctttcctct     60

 atgatgacat cgccctgggg aagagaagct gagaggaact cctcactcag ctagcttcag    120

 gagcatgacg tcatctctac catggaaatt ccactcactc tcctgtgccc ccacatttgt    180

 cctaggcctc agagtcccta taaagagaga ttcccaagtc agtatcagca caggacacag    240

 ctgggttctg aagcttctga gttctgcagc ctcacctctg agaaaacctc ttttccacca    300

 atacc    atg aag ctc tgc gtg act gtc ctg tct ctc ctc atg cta gta     347
          Met Lys Leu Cys Val Thr Val Leu Ser Leu Leu Met Leu Val
            1               5                  10

 gct gcc ttc tgc tct cca gcg ctc tca gca cca aat tcc aaa cca aaa      395
 Ala Ala Phe Cys Ser Pro Ala Leu Ser Ala Pro Asn Ser Lys Pro Lys
  15                  20                  25                  30

 gaa gca agc aag tct gtg ctg atc cca gtg aat cct ggg tcc agg agt      443
 Glu Ala Ser Lys Ser Val Leu Ile Pro Val Asn Pro Gly Ser Arg Ser
                  35                  40                  45

 acg tgt atg acc tgg aac tga ac tgagctgctc agagacagga agtcttcagg      496
 Thr Cys Met Thr Trp Asn 
              50

 gaaggtcacc tgagcccgga tgcttctcca tgagacacat ctcctccata ctcaggactc    556

 ctctccgcag ttcctgtccc ttctcttaat ttaatctttt ttatgtgccg tgttattgta    616

 ttaggtgtca tttccattat ttatattagt ttagccaaag gataagtgtc ccctatgggg    676

 atggtccact gtcactgttt ctctgctgtt gcaaatacat ggataacaca tttgattctg    736

 tgtgttttca taataaaact ttaaaataaa atgcaaaaaa aaaaaaaaaa aaaaaaagtc    796

 ccccgggccc gaaattccca aattttaaac cggaaaatcc ggaaaacccc ccagggtccc    856

 tttaattggg ccttgggccc ccttttaatt ttttttattt aaaccacggt tggccctttt    916

 ttaaggg                                                              923




      <210> 264
      <211> 957
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (65)..(250)

      <400> 264
 tgggttctga agcttctgag ttctgcagcc tcacctctga gaaaacctct tttccaccaa     60

 tacc atg aag ctc tgc gtg act gtc ctg tct ctc ctc atg cta gta gct     109
      Met Lys Leu Cys Val Thr Val Leu Ser Leu Leu Met Leu Val Ala
        1               5                  10                  15

 gcc ttc tgc tct cca gcg ctc tca gca cca agt aag tct act ttt gca      157
 Ala Phe Cys Ser Pro Ala Leu Ser Ala Pro Ser Lys Ser Thr Phe Ala
                  20                  25                  30

 gct gct att tca agt caa ggt gta ggc aga gtc ctt ttt tct agt cat      205
 Ala Ala Ile Ser Ser Gln Gly Val Gly Arg Val Leu Phe Ser Ser His
              35                  40                  45

 ggc tgg caa aca gtg gga tct ggg gat ggg aca aaa ggc agc tag gaa      253
 Gly Trp Gln Thr Val Gly Ser Gly Asp Gly Thr Lys Gly Ser 
          50                  55                  60

 gattgccatg tagtctgctg ctaaatgtag agtctagtag atattcaata acattcaagt    313

 tcctattttc ttaagaatta gcaaccagca gaggaaaatg atgggctgga agtcagactg    373

 ttgaattggc tctgccttta attatttgtt caagcaagcc cctgtccctc tctgtgcctt    433

 ggtttcccca tctgtcatat gaagggagtg cgatgtgttc tgagactgaa tccagttcca    493

 atcttctaga tttctttctc gttcttctct gaagatccac tattcaaaat aagactcctg    553

 ctcatgttag gtgggaatgg atatttgggg ttctggtagc tccacaggga tgctcaatga    613

 agatgcaaaa ttagaagtca aaataaacag ctcccacggg cagtgttgat ctcaccctgg    673

 cctttccttt cagtgggctc agaccctccc accgcctgct gcttttctta caccgcgagg    733

 aagcttcctc gcaactttgt ggtagattac tatgagacca gcagcctctg ctcccagcca    793

 gctgtggtat tccaaaccgt gtatgacctg gaactgaact gagctgctca gagacaggaa    853

 gtcttcaggg aaggtcacct gagcccggat gcttctccat gagacacatc tcctccatac    913

 tcaggactcc tctccgcagt tcctggtcct tctcttattt tctt                     957




      <210> 265
      <211> 464
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (148)..(393)

      <220>
      <221> misc_feature
      <222> (1)...(464)
      <223> n = a,t,c or g

      <400> 265
 gctttttcca tagacgtaac attttgtctc ttatgtgcat tacatagttt cttccaagat     60

 gtcaacttat agttcattta tggtctctgc tttgtagaac ttcaaaattt ctctacaatc    120

 acagttatat attttttctg ggttcat    atg ttg ctt aga aca ctt ccc tat     171
                                  Met Leu Leu Arg Thr Leu Pro Tyr
                                    1               5

 acg aaa aac atg aaa att ttt ttt cat att ttc ttt cat aag tgt cta      219
 Thr Lys Asn Met Lys Ile Phe Phe His Ile Phe Phe His Lys Cys Leu
      10                  15                  20

 ttt aca tat agg tta ttt att act ctt gcg tta att ttg tgg tat agt      267
 Phe Thr Tyr Arg Leu Phe Ile Thr Leu Ala Leu Ile Leu Trp Tyr Ser
  25                  30                  35                  40

 gac ata gag gag tct acc ttt ccc cct cta atg agg tat tgt ccc aac      315
 Asp Ile Glu Glu Ser Thr Phe Pro Pro Leu Met Arg Tyr Cys Pro Asn
                  45                  50                  55

 aca gtg ttg cat aaa tct ttt ttc caa atg tca gct ttt atc act tat      363
 Thr Val Leu His Lys Ser Phe Phe Gln Met Ser Ala Phe Ile Thr Tyr
              60                  65                  70

 caa ttc tca ttg tac ttg agt ctg ttt tag a ttgtctctta tattgatctt      414
 Gln Phe Ser Leu Tyr Leu Ser Leu Phe 
          75                  80

 ttagtttata ggaaagctgc tttacttnnn cnnatttctt tttttttttt               464




      <210> 266
      <211> 711
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (29)..(334)

      <400> 266
 gcctgccaga gtgtggtctc tggacact   atg ggc aca cga ctc ctg aca act      52
                                  Met Gly Thr Arg Leu Leu Thr Thr
                                    1               5

 ctg tta ctt gtc ctc ctg gaa ttg gga ttt gag gtc cag ggg acc caa      100
 Leu Leu Leu Val Leu Leu Glu Leu Gly Phe Glu Val Gln Gly Thr Gln
      10                  15                  20

 cag ccc cat cat gat gac atg cct agt ccg acc ttt cta acc cag gtg      148
 Gln Pro His His Asp Asp Met Pro Ser Pro Thr Phe Leu Thr Gln Val
  25                  30                  35                  40

 cag gaa tct atc tcc aga tac tgg gag tca gca aag aca gcc gcc cag      196
 Gln Glu Ser Ile Ser Arg Tyr Trp Glu Ser Ala Lys Thr Ala Ala Gln
                  45                  50                  55

 aac ctg tac gag aag aca tac ctg ccc gct gta aat gag aaa ctc agg      244
 Asn Leu Tyr Glu Lys Thr Tyr Leu Pro Ala Val Asn Glu Lys Leu Arg
              60                  65                  70

 gac ttg tac agc aaa agc aca gca gcc atg agc act tac aca ggc att      292
 Asp Leu Tyr Ser Lys Ser Thr Ala Ala Met Ser Thr Tyr Thr Gly Ile
          75                  80                  85

 ttt act gac caa gtt ctt tct gtg ctg aag gga gag gag taa cagccag      341
 Phe Thr Asp Gln Val Leu Ser Val Leu Lys Gly Glu Glu 
      90                  95                 100

 accccccatc agtggacaag gggagagtcc cctactcccc tgatccccca ggttcagact    401

 gagctccccc ttcccagtag ctcttgcatc ctcctcccaa ctctagcctg aattcttttc    461

 aataaaaaat acaattcaag ttgcttctca tggatggcac tgcttttctg aggactcaag    521

 gtgccaagat ggaggggctg actcagtcca gccaacattt aatgagcacc tactttatgt    581

 atggagctct aacccatggg tccatgggaa taaagcagtg aatagtaaca ataaatttca    641

 tatcctgaac ttcgagatct ccctggccag gctttgtgat tcaatgggac catcaagaag    701

 gagccccaga                                                           711




      <210> 267
      <211> 1158
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (688)..(1032)

      <400> 267
 ctttccgaaa aattcaggac cacgtgtcac taaatttctg agtaccagtc aagaggctcc     60

 attgtcacca ggttaggtcc cccgccttgg caaactgctg taacagttat acctgaagca    120

 gcagcttgtg tgaggttata ggagactgga aagtgcttgt ccagttaacc gtggtggatt    180

 acctggaaga gcaatttgta catcatcctg ttctttttgg acagaagtta caggatgcaa    240

 tttaggcatc ccgtaagaat ctgtgtaaga aattcatctg gatatttcca tgcatatttt    300

 ctcaattctc acaagcatca catggaataa cttgtcacct aactttacaa aagcaagggc    360

 taagaatgac tacttgtggc ttgggagcca ccaagcttct tcaagtgtct cagaacctac    420

 ctggtgtgag ggccaagtct gtacccctca taccccagcc tcaactggag atgactaagg    480

 ctagtctgtg cacttgaggc cacattcccc tgttcaagga ctgagtgtcc tttacaaatc    540

 ccctccaaat gggagattcc aaaggggctt aagcaaaaga acaatctctg tggcaaacta    600

 agttggccaa gaagctgaag acttaaaatc aaggaaggaa gatgccagat ggcagttttt    660

 acatttattt aaacagaaaa cgtgcac    atg agc tgc cta ctc att ttc ttc     711
                                  Met Ser Cys Leu Leu Ile Phe Phe
                                    1               5

 act gcg cag cct ggc att ggg gtt ggt gac tct gat ggc cag ttg ggc      759
 Thr Ala Gln Pro Gly Ile Gly Val Gly Asp Ser Asp Gly Gln Leu Gly
      10                  15                  20

 agc tct ttc cac gat ggc ttt gcg gtt ctt gga gga aac att gtg agc      807
 Ser Ser Phe His Asp Gly Phe Ala Val Leu Gly Gly Asn Ile Val Ser
  25                  30                  35                  40

 gat ctc ggc aca gta aga ttt gtt gca cat cag cag cac ttc cag ctc      855
 Asp Leu Gly Thr Val Arg Phe Val Ala His Gln Gln His Phe Gln Leu
                  45                  50                  55

 ctt gac gtt gtg gac cag gaa ctt ccg gaa gcc act ggg cag cat gtg      903
 Leu Asp Val Val Asp Gln Glu Leu Pro Glu Ala Thr Gly Gln His Val
              60                  65                  70

 ctt tgt ttt ttt gtt gct tcc ata acc aat gtt ggg cat caa gat ctg      951
 Leu Cys Phe Phe Val Ala Ser Ile Thr Asn Val Gly His Gln Asp Leu
          75                  80                  85

 gcc ctt gaa tct tct acg aac cct gtt gtc aat gcc tct ggg ttt ccg      999
 Ala Leu Glu Ser Ser Thr Asn Pro Val Val Asn Ala Ser Gly Phe Pro
      90                  95                 100

 cca gtt acg ctt aat ttt gac ata tcg gtc tga ctggtgcc ggatgaactt     1050
 Pro Val Thr Leu Asn Phe Asp Ile Ser Val 
 105                 110

 cttggttctc tttttgacga tcttgggctt cacaaggggt ctgagggcgg ccatgatgcc   1110

 gagaaggaga tggctgccac ctccgtaggc agcgccgagg aagagaga                1158




      <210> 268
      <211> 951
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (1)..(951)

      <400> 268
  atg gcg atg atc gaa ttg ggg ttt gga aga cag aat ttt cat cca tta      48
  Met Ala Met Ile Glu Leu Gly Phe Gly Arg Gln Asn Phe His Pro Leu
    1               5                  10                  15

 aag agg aag agt tca ttg ctg ttg aaa ctc ata gct gtt gtc ttt gct       96
 Lys Arg Lys Ser Ser Leu Leu Leu Lys Leu Ile Ala Val Val Phe Ala
              20                  25                  30

 gtg ctt cta ttt tgt gaa ttt tta atc tat tac tta gcg atc ttt cag      144
 Val Leu Leu Phe Cys Glu Phe Leu Ile Tyr Tyr Leu Ala Ile Phe Gln
          35                  40                  45

 tgt aat tgg cct gaa gtg aaa acc aca gcc tct gat ggt gaa cag acc      192
 Cys Asn Trp Pro Glu Val Lys Thr Thr Ala Ser Asp Gly Glu Gln Thr
      50                  55                  60

 aca cgt gag cct gtg ctc aaa gcc atg ttt ttg gct gac acc cat ttg      240
 Thr Arg Glu Pro Val Leu Lys Ala Met Phe Leu Ala Asp Thr His Leu
  65                  70                  75                  80

 ctt ggg gaa ttc cta ggc cac tgg ctg gac aaa tta cga agg gaa tgg      288
 Leu Gly Glu Phe Leu Gly His Trp Leu Asp Lys Leu Arg Arg Glu Trp
                  85                  90                  95

 cag atg gag aga gcg ttc cag aca gct ctg tgg ttg ctg cag ccg gaa      336
 Gln Met Glu Arg Ala Phe Gln Thr Ala Leu Trp Leu Leu Gln Pro Glu
             100                 105                 110

 gtc gtc ttc atc ctg ggg gat atc ttt gat gaa ggg aag tgg agc acc      384
 Val Val Phe Ile Leu Gly Asp Ile Phe Asp Glu Gly Lys Trp Ser Thr
         115                 120                 125

 cct gag gcc tgg gcg gat gat gtg gag cgg ttt cag aaa atg ttc aga      432
 Pro Glu Ala Trp Ala Asp Asp Val Glu Arg Phe Gln Lys Met Phe Arg
     130                 135                 140

 cac cca agt cat gta cag ctg aag gta gtt gct gga aac cat gac att      480
 His Pro Ser His Val Gln Leu Lys Val Val Ala Gly Asn His Asp Ile
 145                 150                 155                 160

 ggc ttc cat tat gag atg aac aca tac aaa gta gaa cgc ttt gag aaa      528
 Gly Phe His Tyr Glu Met Asn Thr Tyr Lys Val Glu Arg Phe Glu Lys
                 165                 170                 175

 gtg ttc agc tct gaa aga ctg ttt tct tgg aaa ggc att aac ttt gtg      576
 Val Phe Ser Ser Glu Arg Leu Phe Ser Trp Lys Gly Ile Asn Phe Val
             180                 185                 190

 atg gtc aac agc gtg gcg ctg aac ggg gat ggc tgt ggc atc tgc tct      624
 Met Val Asn Ser Val Ala Leu Asn Gly Asp Gly Cys Gly Ile Cys Ser
         195                 200                 205

 gaa aca gaa gca gag ctc att gaa gtt tct cac aga ctg aac tgc tcc      672
 Glu Thr Glu Ala Glu Leu Ile Glu Val Ser His Arg Leu Asn Cys Ser
     210                 215                 220

 cga gag cat tat cct ctg tat cag aga agt gat gct aac tgt tct ggg      720
 Arg Glu His Tyr Pro Leu Tyr Gln Arg Ser Asp Ala Asn Cys Ser Gly
 225                 230                 235                 240

 gaa gac gct gct cct cca gag gaa agg gac atc cca ttt aag gag aac      768
 Glu Asp Ala Ala Pro Pro Glu Glu Arg Asp Ile Pro Phe Lys Glu Asn
                 245                 250                 255

 tat gac gtg ctt tca cgg gag gca tca caa aag ctg ctg tgg tgg ctc      816
 Tyr Asp Val Leu Ser Arg Glu Ala Ser Gln Lys Leu Leu Trp Trp Leu
             260                 265                 270

 cag ccg cgc ctg gtt ctc agt ggc cac acg cac agc gcc tgc gag gtg      864
 Gln Pro Arg Leu Val Leu Ser Gly His Thr His Ser Ala Cys Glu Val
         275                 280                 285

 cac cac ggg ggc cga gtc ccc gag ctc agc gtc cca tct ttc agt tgg      912
 His His Gly Gly Arg Val Pro Glu Leu Ser Val Pro Ser Phe Ser Trp
     290                 295                 300

 agg aac aga aac aac ccc agt ttc atc atg gta ccg tga                  951
 Arg Asn Arg Asn Asn Pro Ser Phe Ile Met Val Pro 
 305                 310                 315





      <210> 269
      <211> 1260
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (636)..(881)

      <400> 269
 cagtagattc ggcacaggaa ggactattgt caaaggctat taatggtaaa caagtatatg     60

 caaaacaatt cacatatggg taaaaatttc aaattgtggg tttttgtttt tgctttttag    120

 tttcaaagat tagttatgta gcagcaatat cataaccaaa gcaagtagga agttgactgg    180

 tttggagaat cttcaagtag ttttaaatac tgtaatgtat cagattgtta accaggattt    240

 ttttttcctg tattactgct aaatatatta ctatattaat gcacttttgt atatataact    300

 gtcttctgta cattctgtac ttactacagt gtatataaag cctgttttcc ctgaagctgt    360

 gagggaataa caatagttgt atcataagtc gtttctattt tgagttcctt cttgtacttg    420

 aaagtagttc agtagtgaaa tctaaatgag tgtgtatggt tgtaattaaa actggcaatg    480

 tggcagagct gtcttttgaa actgaatacc agaatgaaaa gtgttgtttt ggttaagaac    540

 tcttataata tattatttct tttgatgtac cctgagttgt tacacagccc actcactgct    600

 gcttactact ttatacttct gagtcagctc ctttc   atg ctc tat ccc aga ata     653
                                          Met Leu Tyr Pro Arg Ile
                                            1               5

 ttt acc aac aga gga gaa ctg ctc cct ttt ctg ttt ctc aca gtt tgg      701
 Phe Thr Asn Arg Gly Glu Leu Leu Pro Phe Leu Phe Leu Thr Val Trp
              10                  15                  20

 tta tgg ctt tat aaa ctt tta ttt ggt gaa agc ccc aga tac cca aat      749
 Leu Trp Leu Tyr Lys Leu Leu Phe Gly Glu Ser Pro Arg Tyr Pro Asn
          25                  30                  35

 gtc att ggc aaa act tat ttt ttt ttc tgg aca gat cag att tct aga      797
 Val Ile Gly Lys Thr Tyr Phe Phe Phe Trp Thr Asp Gln Ile Ser Arg
      40                  45                  50

 gag agc aga ttt cta gag aga tta gca ttc ata gta agt gaa aat tgt      845
 Glu Ser Arg Phe Leu Glu Arg Leu Ala Phe Ile Val Ser Glu Asn Cys
  55                  60                  65                  70

 cta att ttt tta atc cat gct att act ggg cag tag gtct aatttttttt      895
 Leu Ile Phe Leu Ile His Ala Ile Thr Gly Gln 
                  75                  80

 gacaaaaaat agatctattt tccttatata ttgatttaga atcttaagtt agaattttat    955

 agaagaaatg tctgagcagt tctatgtatg gaggagcaat tcagcttttc agcagcaact   1015

 ttatcttttg ccactagagg gagatctgtg gttgctttct cctttggaga atagctgctt   1075

 tgcttttatt tttaatttct aaggttggaa tagaacttat tctcaaaatt cctttagtgt   1135

 tattaaatat tttcatttat tagtcaaagg taagttaatt aagcttgttt aatgatgcca   1195

 atcttatgct tttctgtaat cttcaatttt taataaatgt gagttagata ctaaaaaaaa   1255

 aaaaa                                                               1260




      <210> 270
      <211> 500
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (162)..(404)

      <400> 270
 aggttatcta gggctctctc actcatgaag cagactccta gtcctggagt gactgtgtac     60

 gagagcgtgg ttgtggtgct gtatgtgaac gcatgcaagc ttgattcacc ttcagggggc    120

 tgataaccta gtaaatcatc aaaatgagat cataagtgtt a    atg tac act gga     173
                                                  Met Tyr Thr Gly
                                                    1

 cat gaa aac aaa gac tgg ttt agc agc aga cat tgg ttt act ctg cag      221
 His Glu Asn Lys Asp Trp Phe Ser Ser Arg His Trp Phe Thr Leu Gln
   5                  10                  15                  20

 cct gtg ttt tct gtt tcc ccc ttt ccc acc tcc ttc ccc cca ccc aat      269
 Pro Val Phe Ser Val Ser Pro Phe Pro Thr Ser Phe Pro Pro Pro Asn
                  25                  30                  35

 cct ttt ttt ttt ctt ttt tgc ttt tct ttt ctt ttt ttt agt ttt tat      317
 Pro Phe Phe Phe Leu Phe Cys Phe Ser Phe Leu Phe Phe Ser Phe Tyr
              40                  45                  50

 tta ctt tac cta gta tgc ctt ttt tta gtt gct tct caa gtc aaa aaa      365
 Leu Leu Tyr Leu Val Cys Leu Phe Leu Val Ala Ser Gln Val Lys Lys
          55                  60                  65

 ctt ttc agg aag gtt tcc ctg tgc att tgc acc aaa tga atgtttgatg       414
 Leu Phe Arg Lys Val Ser Leu Cys Ile Cys Thr Lys 
      70                  75                  80

 ctatgaaaag ctttccatat catcaaaact aatttgtgta gatttttgca tgaaaaaaat    474

 cataaatttc cctcaaaata gactgg                                         500




      <210> 271
      <211> 1051
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (67)..(372)

      <400> 271
 gttccccagt ggtaagccgc aatctagctg acgtggcccc aaccccacat tccttcctgc     60

 cctgca   atg tct gaa gaa acc cta cag agc aaa ttg gcg gct gca aag     108
          Met Ser Glu Glu Thr Leu Gln Ser Lys Leu Ala Ala Ala Lys
            1               5                  10

 aaa aag ctg cct tgg ggt gcg gtg cag ggg tcc aga gcc atg tcg gac      156
 Lys Lys Leu Pro Trp Gly Ala Val Gln Gly Ser Arg Ala Met Ser Asp
  15                  20                  25                  30

 ctg tta ctg tta cta ctg gac ctg act ctg tta ctg ctg ctg atg ctg      204
 Leu Leu Leu Leu Leu Leu Asp Leu Thr Leu Leu Leu Leu Leu Met Leu
                  35                  40                  45

 ctg ggc ttt gcc ggg tac tca ggg cag ttg gct ggg gtg gca gtg agt      252
 Leu Gly Phe Ala Gly Tyr Ser Gly Gln Leu Ala Gly Val Ala Val Ser
              50                  55                  60

 gcc ggc tca ccc ccc atc cct aca agt tcc atg tgg agc cct atg gtg      300
 Ala Gly Ser Pro Pro Ile Pro Thr Ser Ser Met Trp Ser Pro Met Val
          65                  70                  75

 aga ctg ggt ggc ttc tca cca gag ctg cag cat ctc ccc caa act ctg      348
 Arg Leu Gly Gly Phe Ser Pro Glu Leu Gln His Leu Pro Gln Thr Leu
      80                  85                  90

 ctc cat cgc tgt cca cta gga taa ccctgcatgg ttctgctcta cacctatact     402
 Leu His Arg Cys Pro Leu Gly 
  95                 100

 ccagagatga atcagaccta gccctgccct caggaggctc tgtgaggctg ggaagtcaac    462

 cccacacaag tggttctcca acaagacacg gtgcttgatg tccacagaac tttgagctgt    522

 gggttcaggg atgctgccat gagtctgctg gggagcctcg gggaaggggt agctgggcct    582

 tctcatcatc ctcctttctt cagtgaacga attaaaaaag agatgcagtg aagacacatt    642

 tgcttcttat ccacacatca cttcctctca ctattagtca atgtaggtag agctgagaat    702

 agcagtttcc tgggaggaca accacttctt agcgataaac aacacactga aaaaaagtat    762

 aaatcattca ttaaaagcta acatatttta agaaaaataa gcatatgcct gaataaaatg    822

 cttgtggaaa aataaagatt cattttgttg atttctattg agctcagata acatttgact    882

 aaaagcttgc aaatatacag cagaaaaaac aatattattt gaaataagaa ttttgtgaat    942

 aaagttattc tgtcaatgga agtaaaaata ttatgacctc atactaatag tctcatctat   1002

 acttgtacaa cattaaatgc tttttattaa aaaactcaga acaacgaca               1051




      <210> 272
      <211> 498
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (1)..(498)

      <400> 272
  atg gcg acg ccg ctg cct ccg ccc tcc ccg cgg cac ctg cgg ctg ctg      48
  Met Ala Thr Pro Leu Pro Pro Pro Ser Pro Arg His Leu Arg Leu Leu
    1               5                  10                  15

 cgg ctg ccg ctc tcc ggc ctc gcc ctt gtg ctg atc ctg gcg ttc tgt       96
 Arg Leu Pro Leu Ser Gly Leu Ala Leu Val Leu Ile Leu Ala Phe Cys
              20                  25                  30

 gtg gcc ggt gca gcc gcc ctc tcc gta gcc tcc ctc tgc tgg tgc agg      144
 Val Ala Gly Ala Ala Ala Leu Ser Val Ala Ser Leu Cys Trp Cys Arg
          35                  40                  45

 ctg cag cgt gag atc cgc ctg act cag aag gcc gac tac gcc act gcg      192
 Leu Gln Arg Glu Ile Arg Leu Thr Gln Lys Ala Asp Tyr Ala Thr Ala
      50                  55                  60

 aag gcc cct ggc tca cct gca gct ccc cgg atc tcg cct ggg gac cag      240
 Lys Ala Pro Gly Ser Pro Ala Ala Pro Arg Ile Ser Pro Gly Asp Gln
  65                  70                  75                  80

 cgg ctg gca cag agc gcg gag atg tac cac tac cag cac caa cgg caa      288
 Arg Leu Ala Gln Ser Ala Glu Met Tyr His Tyr Gln His Gln Arg Gln
                  85                  90                  95

 cag atg ctg tgc ctg gag tgg cat aaa gag cca ccc aag gag atg gac      336
 Gln Met Leu Cys Leu Glu Trp His Lys Glu Pro Pro Lys Glu Met Asp
             100                 105                 110

 acg gcc tcc tcg gat gag gag aat gag gac gga gac ttc acg gtg tac      384
 Thr Ala Ser Ser Asp Glu Glu Asn Glu Asp Gly Asp Phe Thr Val Tyr
         115                 120                 125

 gag tgc ccg ggc ctg gcc ccg acc ggg gaa atg gag gtg cgc aac cct      432
 Glu Cys Pro Gly Leu Ala Pro Thr Gly Glu Met Glu Val Arg Asn Pro
     130                 135                 140

 ctg ttc gac cac gcc gca ctg tcc gcg ccc ctg ccg gcc ccc agc tca      480
 Leu Phe Asp His Ala Ala Leu Ser Ala Pro Leu Pro Ala Pro Ser Ser
 145                 150                 155                 160

 ccg cct gca ctg cca tga                                              498
 Pro Pro Ala Leu Pro 
                 165





      <210> 273
      <211> 735
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (94)..(735)

      <400> 273
 aaaatttgat cgccctagta gatccgcctg caggaattcg gcacgagacg ggctgggctt     60

 cgcttctgct gtcccctgcg atccaactcc cca atg gca gcg gcc gcc agc ccc     114
                                      Met Ala Ala Ala Ala Ser Pro
                                        1               5

 gcg ttc ctt cta cgc ctc ccg ctt ctg ctc ctg ctg tcc agc tgg tgc      162
 Ala Phe Leu Leu Arg Leu Pro Leu Leu Leu Leu Leu Ser Ser Trp Cys
          10                  15                  20

 agg acc ggg ctg gcc gac cct cac tct ctt tgc tat gac atc acc gtc      210
 Arg Thr Gly Leu Ala Asp Pro His Ser Leu Cys Tyr Asp Ile Thr Val
      25                  30                  35

 atc cct aag ttc aga cct gga cca cgg tgg tgt gcg gtt caa ggc cag      258
 Ile Pro Lys Phe Arg Pro Gly Pro Arg Trp Cys Ala Val Gln Gly Gln
  40                  45                  50                  55

 gtg gat gaa aag act ttt ctt cac tat gac tgt ggc agc aag aca gtc      306
 Val Asp Glu Lys Thr Phe Leu His Tyr Asp Cys Gly Ser Lys Thr Val
                  60                  65                  70

 aca ccc gtc agt ccc ctg ggg aag aaa cta aat gtc aca acg gcc tgg      354
 Thr Pro Val Ser Pro Leu Gly Lys Lys Leu Asn Val Thr Thr Ala Trp
              75                  80                  85

 aaa gca cag aac cca gta ctg aga gag gtg gtg gac ata ctt aca gag      402
 Lys Ala Gln Asn Pro Val Leu Arg Glu Val Val Asp Ile Leu Thr Glu
          90                  95                 100

 caa ctg ctt gac att cag ctg gag aat tac ata ccc aag gaa ccc ctc      450
 Gln Leu Leu Asp Ile Gln Leu Glu Asn Tyr Ile Pro Lys Glu Pro Leu
     105                 110                 115

 acc ctg cag gcc agg atg tct tgt gag cag aaa gcc gaa gga cac ggc      498
 Thr Leu Gln Ala Arg Met Ser Cys Glu Gln Lys Ala Glu Gly His Gly
 120                 125                 130                 135

 agt gga tct tgg cag ctc agt ttc gat gga cag atc ttc ctc ctc ttt      546
 Ser Gly Ser Trp Gln Leu Ser Phe Asp Gly Gln Ile Phe Leu Leu Phe
                 140                 145                 150

 gac tca gaa aac aga atg tgg aca acg gtt cat cct gga gcc aga aag      594
 Asp Ser Glu Asn Arg Met Trp Thr Thr Val His Pro Gly Ala Arg Lys
             155                 160                 165

 atg aaa gaa aag tgg gag aat gac aag gat atg acc atg tcc ttc cat      642
 Met Lys Glu Lys Trp Glu Asn Asp Lys Asp Met Thr Met Ser Phe His
         170                 175                 180

 tac atc tca atg gga gac tgc aca gga tgg ctt gag gac ttc ttg atg      690
 Tyr Ile Ser Met Gly Asp Cys Thr Gly Trp Leu Glu Asp Phe Leu Met
     185                 190                 195

 ggc atg gac agc acc ctg gag cca agt gca gga gct acc aaa tag          735
 Gly Met Asp Ser Thr Leu Glu Pro Ser Ala Gly Ala Thr Lys 
 200                 205                 210





      <210> 274
      <211> 581
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (205)..(534)

      <400> 274
 gtgactggtg gctcctgcct gtacacactc tcttgactca gtgtgctctc tcccctgcct     60

 gggccacagc tgcagcatcc tcaagagtct ccccgtacca gccactccct gctgatttgt    120

 cctgcctcct gcagtcctaa aggcagatct gaccctacca ccaccctgtt tctagccctt    180

 gcctggctcc ctactgctca cagg   atg agg tcc atg cct ggg aac tgc ctc     231
                              Met Arg Ser Met Pro Gly Asn Cys Leu
                                1               5

 cct ctg tgg cct cat ctc cta gcc cgc cct ccc cgt gag ctg tgg cct      279
 Pro Leu Trp Pro His Leu Leu Ala Arg Pro Pro Arg Glu Leu Trp Pro
  10                  15                  20                  25

 gat gtc atg ggt ctg cct atg gtt gca agt gtg ctg tgc ttt tct ggc      327
 Asp Val Met Gly Leu Pro Met Val Ala Ser Val Leu Cys Phe Ser Gly
                  30                  35                  40

 ttc tgg gcc ttt gct cac gcc att ctg cct gcc agg agt gct ctc ctt      375
 Phe Trp Ala Phe Ala His Ala Ile Leu Pro Ala Arg Ser Ala Leu Leu
              45                  50                  55

 tcc tca cct ccc acc tct gta ccc ctc aca tcc ctg ttg agg cag aag      423
 Ser Ser Pro Pro Thr Ser Val Pro Leu Thr Ser Leu Leu Arg Gln Lys
          60                  65                  70

 tcc atc tct gga agc ttt cct aga gcc ccc aag ctg gcc ttg atg gtt      471
 Ser Ile Ser Gly Ser Phe Pro Arg Ala Pro Lys Leu Ala Leu Met Val
      75                  80                  85

 ctg ctg cca ccc acc ctg ggt ctc ctt tac agc acc cac ctg ctg cac      519
 Leu Leu Pro Pro Thr Leu Gly Leu Leu Tyr Ser Thr His Leu Leu His
  90                  95                 100                 105

 cgt cac tgt ttg tag gggaataata aaccgacaca accagaggcc aggccccagg      574
 Arg His Cys Leu 


 gcattcc                                                              581




      <210> 275
      <211> 2552
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (912)..(1256)

      <400> 275
 gttggctgtc attgtcatct ccaggtacct aaagaaatag aggccacatg ggatgcagtg     60

 tggcttctcc catccctatc cccaacccac ctgacccaag agaaggttcc cctagcacac    120

 tcaaacaaga cccccttgtc ttctggtgtc tttgaaatgt caagataaca gccactgggt    180

 gtctgcggaa ccacctctcc agccctaaag caaatctgtc tcatgttgcc ttataaaaga    240

 gaagctcata atgaatgttt agcctttatc agttacatcc aatcttggaa taagtcatag    300

 agaataacaa gtctgggact gacgtaggaa aaacagtagt ctgtttaagt tgagaggagg    360

 aggaggtgga cgagagaagg gaggagaggg aagaactgaa atgtctcctc acccagggtg    420

 gttattgggc ccaacttggg atggggttga gtacgaaggt taaaaaacat atactttggt    480

 attatattgg tcattgtaat agcagttgta aaatatgggg ggaaaaggga tcatttgctt    540

 tcctttcatg gtgttaatgt gtgcctgaat ctatagccgc taaaatgtaa ggctgtccac    600

 ctgacttatt taaatattat cagagaatag aaagtaatca ctttttaagt gtacctatgt    660

 gctgcccctt aaaacattca tggcatctgg caaatagacc cttgtaggct ggcctggcat    720

 attcagatgt tgccgcatca tcacagagaa ggtcaaatga agatgtaacc attgctgctc    780

 atgtgtcttc tctaagcaac aaggggagcg ggatgtaaga gagaagttgc taatgatact    840

 gtacaaagga tggattaaat aatgaagtca atttcattga tagaaaatgc aaattttaag    900

 attctcagtg t atg agg tct cag cct cgg gag cat tta ttt ttt act ttc     950
              Met Arg Ser Gln Pro Arg Glu His Leu Phe Phe Thr Phe
                1               5                  10

 ctg cta aaa atc cac tgg gga ggt ata aaa ttc act cca aag aag ttt      998
 Leu Leu Lys Ile His Trp Gly Gly Ile Lys Phe Thr Pro Lys Lys Phe
      15                  20                  25

 gcc tgg gcc aaa agc ctc cag gtt cct tct gag aac aaa ata cta atg     1046
 Ala Trp Ala Lys Ser Leu Gln Val Pro Ser Glu Asn Lys Ile Leu Met
  30                  35                  40                  45

 att ttt ttt ttt ttt ggc tgc ttg gga gag act ttc agc att ctt tca     1094
 Ile Phe Phe Phe Phe Gly Cys Leu Gly Glu Thr Phe Ser Ile Leu Ser
                  50                  55                  60

 cga tat cca gat atg tcc ctt cag cac aca cac tca act ttc tca tct     1142
 Arg Tyr Pro Asp Met Ser Leu Gln His Thr His Ser Thr Phe Ser Ser
              65                  70                  75

 ggt tcg ttt cat cct ccc gaa aga acg gtg ctc tcc cac tct tac tct     1190
 Gly Ser Phe His Pro Pro Glu Arg Thr Val Leu Ser His Ser Tyr Ser
          80                  85                  90

 att tca aag agc tac tct gtc tca acc aca gca gcc ctg cca aga aaa     1238
 Ile Ser Lys Ser Tyr Ser Val Ser Thr Thr Ala Ala Leu Pro Arg Lys
      95                 100                 105

 ggc aag atg aaa ggc tag agcatg tgctaccttg agatttcaag aagtgtccta     1292
 Gly Lys Met Lys Gly 
 110

 cctcagctga agatggagaa acggggagtg gagaggggat cagcccaggg taccatgtga   1352

 tgactaatat gccactcatt aagggctttt acctcggctg tccacatcca gtcatgcatt   1412

 tggggccagg catgcctgcg aaatgattga cattcctgta ggtgccccat agaggtgtgg   1472

 cattgagaaa ttatgtctgg aaaatacagc cagtgtagtg accagctgag ttaccatata   1532

 gcctgatgat tccccttctg taacagaagg tgacaacaac tttgtgaact ttctatatct   1592

 ttatctgatg ccccaagtgg catcttcttt atgtacatgc cttagttgag aatatgagac   1652

 tgctctaatc tttgtgaatg ccttcacact tcagctgagg atgtcacctt ctctgtcact   1712

 ccccatcctg caacctctgc ctttgctctg tctaccccag caattttcat agtgttatcc   1772

 aggtactgtg ctaaaaggtc agctcttctg taaaatgcca tgcttcgcag cttcaaaaag   1832

 caaaattctg tatttcatgg agggagggaa gggtcattct cttctaagaa aaatagactg   1892

 gacaggcgaa tgcatgcatg catgtgttta gagttgcttc tcagaagaca aagagatgat   1952

 agcaactatt aaaatatgaa tgaatgaatg agtgaatgag ttgaaggcct agctcgggct   2012

 gataaagctt ttgccttagt agaggtttta tgtcaacacc ttcaggaggg aagcccttat   2072

 ttctgggttg aactcccctt ccatgatatt atgctagcaa ttgccatcac ttagttcctg   2132

 gcgaaggcag aaaaagaaaa caaaaaatca gcattgtcat tgacaaaact ggatgctgaa   2192

 gataaagtaa aattgtcttt tcccttgtcc cacatttttg ggattaaagc cagaattgaa   2252

 taggaaatac agtactattt ctgaagttga tagccgatct ttaagaagac cctgtcttta   2312

 aaatgaaact agcaggcaaa cacctaaata atcgaaaatt accaaagaac aacaacgaaa   2372

 caagaaaacc taaagatttt tacttcctat tcttattcct ttccttatta ctgtgacacc   2432

 ccttgcattg ctcagttgcc tgtgtgtcaa aataacttgt ggacgttgga aattatttga   2492

 aaatgtattg tgtggaatgt aataaaatga tgatattttt atacaaaaaa aaaaaaaaag   2552




      <210> 276
      <211> 3418
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (78)..(2627)

      <400> 276
 gtcacacctg agccagcagg ttgtgcatcc agaggagcgc aggcagggtt ccctgctggg     60

 gcccgggctg cccagcc   atg ctt tgg gca ctc tgg cca agg tgg ctg gca     110
                      Met Leu Trp Ala Leu Trp Pro Arg Trp Leu Ala
                        1               5                  10

 gac aag atg ctg ccc ctc ctg ggg gca gtg ctg ctt cag aag aga gag      158
 Asp Lys Met Leu Pro Leu Leu Gly Ala Val Leu Leu Gln Lys Arg Glu
              15                  20                  25

 aag agg ggc cct ctg tgg agg cac tgg cgg cgg gaa acc tac cca tac      206
 Lys Arg Gly Pro Leu Trp Arg His Trp Arg Arg Glu Thr Tyr Pro Tyr
          30                  35                  40

 tat gac ctc cag gtg aag gtg ctg agg gcc aca aac atc cgg ggc aca      254
 Tyr Asp Leu Gln Val Lys Val Leu Arg Ala Thr Asn Ile Arg Gly Thr
      45                  50                  55

 gac ctg ctg tcc aaa gcc gac tgc tat gtg caa ctg tgg ctg ccc acg      302
 Asp Leu Leu Ser Lys Ala Asp Cys Tyr Val Gln Leu Trp Leu Pro Thr
  60                  65                  70                  75

 gcg tcc cca agc cct gcc cag act agg ata gtg gcc aac tgc agt gac      350
 Ala Ser Pro Ser Pro Ala Gln Thr Arg Ile Val Ala Asn Cys Ser Asp
                  80                  85                  90

 ccc gag tgg aat gag acc ttc cac tac cag atc cat ggt gct gtg aag      398
 Pro Glu Trp Asn Glu Thr Phe His Tyr Gln Ile His Gly Ala Val Lys
              95                 100                 105

 aac gtc ctg gag ctc acc ctc tat gac aag gac atc ctg ggc agc gac      446
 Asn Val Leu Glu Leu Thr Leu Tyr Asp Lys Asp Ile Leu Gly Ser Asp
         110                 115                 120

 cag ctc tct ctg ctc ctg ttt gac ctg aga agc ctc aag tgt ggc caa      494
 Gln Leu Ser Leu Leu Leu Phe Asp Leu Arg Ser Leu Lys Cys Gly Gln
     125                 130                 135

 cct cac aaa cac acc ttc cca ctc aac cac cag gat tca caa gag ctg      542
 Pro His Lys His Thr Phe Pro Leu Asn His Gln Asp Ser Gln Glu Leu
 140                 145                 150                 155

 cag gtg gaa ttt gtt ctg gag aag agc cag gtg cct gca tct gaa gtc      590
 Gln Val Glu Phe Val Leu Glu Lys Ser Gln Val Pro Ala Ser Glu Val
                 160                 165                 170

 atc acc aac ggg gtt ctg gtg gct cac ccc tgt ctg aga atc cag ggc      638
 Ile Thr Asn Gly Val Leu Val Ala His Pro Cys Leu Arg Ile Gln Gly
             175                 180                 185

 acg ctc cgg gga gat ggg aca gcc cca cgg gaa gag tac ggc tct agg      686
 Thr Leu Arg Gly Asp Gly Thr Ala Pro Arg Glu Glu Tyr Gly Ser Arg
         190                 195                 200

 cag ctc cag ctg gca gtg cct gga gcc tac gag aag cca cag ctc ttg      734
 Gln Leu Gln Leu Ala Val Pro Gly Ala Tyr Glu Lys Pro Gln Leu Leu
     205                 210                 215

 ccc ctg cag cct ccc aca gag cca ggc ctc cca ccc acc ttt acc ttc      782
 Pro Leu Gln Pro Pro Thr Glu Pro Gly Leu Pro Pro Thr Phe Thr Phe
 220                 225                 230                 235

 cac gtg aac cca gtg ctg agc tcc agg cta cac gtg gag ctg atg gag      830
 His Val Asn Pro Val Leu Ser Ser Arg Leu His Val Glu Leu Met Glu
                 240                 245                 250

 ctg ctg gca gct gtg cag agt ggc ccc agc gca gag ttg gag gct cag      878
 Leu Leu Ala Ala Val Gln Ser Gly Pro Ser Ala Glu Leu Glu Ala Gln
             255                 260                 265

 acc agc aag ctg ggc gag ggg ggc atc ctg ctc tcc tct ctg ccc cta      926
 Thr Ser Lys Leu Gly Glu Gly Gly Ile Leu Leu Ser Ser Leu Pro Leu
         270                 275                 280

 ggc cag gag gaa cag tgt tct gtg gcc ctg ggg gag ggc cag gag gtg      974
 Gly Gln Glu Glu Gln Cys Ser Val Ala Leu Gly Glu Gly Gln Glu Val
     285                 290                 295

 gct ctg agc atg aag gtg gaa atg agc tcc ggg gac cta gac cta cgc     1022
 Ala Leu Ser Met Lys Val Glu Met Ser Ser Gly Asp Leu Asp Leu Arg
 300                 305                 310                 315

 ctt ggc ttt gac ctc tct gac ggg gag cag gag ttt ctg gac agg agg     1070
 Leu Gly Phe Asp Leu Ser Asp Gly Glu Gln Glu Phe Leu Asp Arg Arg
                 320                 325                 330

 aag cag gtc gtg tcc aag gcc ctg cag caa gtg ctg gga ttg agt gag     1118
 Lys Gln Val Val Ser Lys Ala Leu Gln Gln Val Leu Gly Leu Ser Glu
             335                 340                 345

 gct ctg gac agt ggc cag gtg cct gta gtg gct gtg ttg ggt tcc ggg     1166
 Ala Leu Asp Ser Gly Gln Val Pro Val Val Ala Val Leu Gly Ser Gly
         350                 355                 360

 ggt gga acc cga gcc atg tct tct ctg tac ggc agc ctg gca ggg ttg     1214
 Gly Gly Thr Arg Ala Met Ser Ser Leu Tyr Gly Ser Leu Ala Gly Leu
     365                 370                 375

 cag gag ctc ggc ctt cta gac act gtg acc tac ctg agt ggg gtc tct     1262
 Gln Glu Leu Gly Leu Leu Asp Thr Val Thr Tyr Leu Ser Gly Val Ser
 380                 385                 390                 395

 ggg tct acc tgg tgc atc tcc aca ctc tac agg gac cca gcc tgg tcc     1310
 Gly Ser Thr Trp Cys Ile Ser Thr Leu Tyr Arg Asp Pro Ala Trp Ser
                 400                 405                 410

 cag gtg gcc ttg cag ggc ccc att gag cgt gcc cag gtt cac gtc tgc     1358
 Gln Val Ala Leu Gln Gly Pro Ile Glu Arg Ala Gln Val His Val Cys
             415                 420                 425

 agc agt aag atg gga gct ttg tcc acg gag cgg cta cag tac tac act     1406
 Ser Ser Lys Met Gly Ala Leu Ser Thr Glu Arg Leu Gln Tyr Tyr Thr
         430                 435                 440

 cag gaa ctg ggg gtc cgg gag cgc agt ggc cac agc gtg tcc ctc atc     1454
 Gln Glu Leu Gly Val Arg Glu Arg Ser Gly His Ser Val Ser Leu Ile
     445                 450                 455

 gac ctc tgg ggc ctc ctt gtt gag tat ctc ctg tac cag gag gag aac     1502
 Asp Leu Trp Gly Leu Leu Val Glu Tyr Leu Leu Tyr Gln Glu Glu Asn
 460                 465                 470                 475

 cct gcc aag ctg tct gac caa cag gag gcg gtc cgc cag ggt cag aac     1550
 Pro Ala Lys Leu Ser Asp Gln Gln Glu Ala Val Arg Gln Gly Gln Asn
                 480                 485                 490

 cct tac ccc att tac acc agt gtc aac gtc cgc acc aac ttg agt ggg     1598
 Pro Tyr Pro Ile Tyr Thr Ser Val Asn Val Arg Thr Asn Leu Ser Gly
             495                 500                 505

 gaa gat ttt gca gag tgg tgc gag ttc acg ccc tat gag gtt ggc ttc     1646
 Glu Asp Phe Ala Glu Trp Cys Glu Phe Thr Pro Tyr Glu Val Gly Phe
         510                 515                 520

 ccc aag tac ggg gct tat gtt ccc acc gag ctc ttc ggc tca gaa ctc     1694
 Pro Lys Tyr Gly Ala Tyr Val Pro Thr Glu Leu Phe Gly Ser Glu Leu
     525                 530                 535

 ttc atg gga cga ttg ctg cag ctc cag cct gaa ccc cgg atc tgt tac     1742
 Phe Met Gly Arg Leu Leu Gln Leu Gln Pro Glu Pro Arg Ile Cys Tyr
 540                 545                 550                 555

 ctg caa ggt atg tgg ggc agc gcc ttt gcc acc agc ctg gat gag atc     1790
 Leu Gln Gly Met Trp Gly Ser Ala Phe Ala Thr Ser Leu Asp Glu Ile
                 560                 565                 570

 ttc cta aag acc gcc ggc tcg ggc ctc agc ttc ctg gag tgg tac aga     1838
 Phe Leu Lys Thr Ala Gly Ser Gly Leu Ser Phe Leu Glu Trp Tyr Arg
             575                 580                 585

 ggc agt gtg aat atc aca gac gac tgc cag aag cct cag ctg cac aac     1886
 Gly Ser Val Asn Ile Thr Asp Asp Cys Gln Lys Pro Gln Leu His Asn
         590                 595                 600

 ccc tcg agg ctg cga acg agg ctc ctc acc cca cag ggg ccc ttc tcc     1934
 Pro Ser Arg Leu Arg Thr Arg Leu Leu Thr Pro Gln Gly Pro Phe Ser
     605                 610                 615

 cag gct gtg ctg gac ata ttc acc tcc cgc ttc act tcc gcc cag agc     1982
 Gln Ala Val Leu Asp Ile Phe Thr Ser Arg Phe Thr Ser Ala Gln Ser
 620                 625                 630                 635

 ttt aac ttc acc cgg ggt ctc tgc ttg cac aag gac tat gtg gct ggc     2030
 Phe Asn Phe Thr Arg Gly Leu Cys Leu His Lys Asp Tyr Val Ala Gly
                 640                 645                 650

 agg gag ttc gtg gcc tgg aaa gac aca cac ccg gac gcc ttc ccc aac     2078
 Arg Glu Phe Val Ala Trp Lys Asp Thr His Pro Asp Ala Phe Pro Asn
             655                 660                 665

 cag ctc acc ccc atg cgg gac tgc ctg tac ctg gtg gac gga ggc ttt     2126
 Gln Leu Thr Pro Met Arg Asp Cys Leu Tyr Leu Val Asp Gly Gly Phe
         670                 675                 680

 gcc atc aac tct ccg ttc cca ctg gct ctg ctg cct cag aga gca gtg     2174
 Ala Ile Asn Ser Pro Phe Pro Leu Ala Leu Leu Pro Gln Arg Ala Val
     685                 690                 695

 gac ctc att ctg tcc ttt gac tat tcc ttg gaa gcc cct ttt gag gtc     2222
 Asp Leu Ile Leu Ser Phe Asp Tyr Ser Leu Glu Ala Pro Phe Glu Val
 700                 705                 710                 715

 ttg aag atg aca gag aag tac tgc ctg gac cga gga atc ccc ttc cct     2270
 Leu Lys Met Thr Glu Lys Tyr Cys Leu Asp Arg Gly Ile Pro Phe Pro
                 720                 725                 730

 agc atc gag gtg ggc cct gag gac gtg gag gag gcc cgt gag tgc tat     2318
 Ser Ile Glu Val Gly Pro Glu Asp Val Glu Glu Ala Arg Glu Cys Tyr
             735                 740                 745

 ctg ttt gcc aag gct gag gac ccc cgc tcc ccc att gtg ctg cac ttc     2366
 Leu Phe Ala Lys Ala Glu Asp Pro Arg Ser Pro Ile Val Leu His Phe
         750                 755                 760

 ccc ctg gtt aac cgt acc ttc cgc aca cac ctg gcc cca ggt gtg gag     2414
 Pro Leu Val Asn Arg Thr Phe Arg Thr His Leu Ala Pro Gly Val Glu
     765                 770                 775

 cga caa aca gct gag gag aag gcc ttt ggg gac ttt gtc atc aac agg     2462
 Arg Gln Thr Ala Glu Glu Lys Ala Phe Gly Asp Phe Val Ile Asn Arg
 780                 785                 790                 795

 cca gac acc ccc tat ggc atg atg aac ttc acc tat gag ccc cag gac     2510
 Pro Asp Thr Pro Tyr Gly Met Met Asn Phe Thr Tyr Glu Pro Gln Asp
                 800                 805                 810

 ttt tat cgg ctg gtg gcc ctc agt cga tac aac gtc ctg aac aat gtg     2558
 Phe Tyr Arg Leu Val Ala Leu Ser Arg Tyr Asn Val Leu Asn Asn Val
             815                 820                 825

 gag acc ttg aag tgc gcc ctc cag ctg gct ctg gac cgg cac cag gct     2606
 Glu Thr Leu Lys Cys Ala Leu Gln Leu Ala Leu Asp Arg His Gln Ala
         830                 835                 840

 cgg gag agg gca ggg gcc tga cc aaggcaggaa gcggaggact gtgacagaga     2659
 Arg Glu Arg Ala Gly Ala 
     845

 ggagacacac tgctcatggt cagggcttgt agagggagga gcgatgggga ctctgtgcag   2719

 gatctgcttc ccttctctcc aggacctgcc tcgaggtgcc ccaggccccg gaaagctctt   2779

 gcagaattgc agcttggact ggggcagggc tctccttgtg tgtttttgga gaagatgggc   2839

 agtagatcgc tccagggact cttggggatg tagggcagaa gagaacagca ctcatttcac   2899

 agcggggtgt ggagagaatc aggtgagcca cagagcccac cccagacaca gaaggacctc   2959

 agagggccca agtcctcaga cccacacaga acaggggctg agggcaccga gaagccagct   3019

 gtcctcctta cactgagatg gaaagcagag atgcatccat ccacacttcc tgcagagcgg   3079

 cccaagcccc aaccccacct cgagctcctg gatgcactgc tatcaagaac aatgaggggc   3139

 tgaggggatg gccagcctat gttgctgact ccatcatcct aaccctcctt ctgccttctg   3199

 gtctcctcgt gcctcctccc agatcaccct tctcttccca gcgccctaaa gcctgtgggg   3259

 tgatgtccca ttctggctgc tccaggtggg agatgtgcgc gtgtctccct gccagttacc   3319

 caggcttcac tcttcgaacc tggaccacag tctctggtga tgtgtgtagt ggccacatca   3379

 tgcaaatata gtctcaccat tcctaggaaa aaaaaaaaa                          3418




      <210> 277
      <211> 946
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (422)..(790)

      <400> 277
 gaagagctct acagattgcc ggaatgtggg gttttggaag ctcaaaggcc aataattagc     60

 tactaaaaca cgtgtttctt tgcatttcag ctttcccagg gtagggaggc tggatgtcca    120

 ccacacagag ctgtggagct cactcctggc tgtgtcacac ggagcctggg tgggctaagc    180

 atttgcagtt ttcagcagct tccaaaggac cctactgagc agccagggga agcccgtgag    240

 agtgaagagt gagtgacttc cctcctgcac agttctgctg cagcctctgc cccatctact    300

 gccacgcctg ttcctgctgc agcctcagcc ccatctactg ccacgcctgt tcctgctgca    360

 gcctctgccc catctacctc cacgcccggc tcttgctgca gcctctgccg catctacctc    420

 c    atg cct ggt tcc tgc tgc agc ctc tgc ccc acc tac ctc cac gcc     466
      Met Pro Gly Ser Cys Cys Ser Leu Cys Pro Thr Tyr Leu His Ala
        1               5                  10                  15

 cgg ctc ctg ctg cag cct ctg ccc cat cta cct cca cgc ctg ttc ctg      514
 Arg Leu Leu Leu Gln Pro Leu Pro His Leu Pro Pro Arg Leu Phe Leu
                  20                  25                  30

 ctg cag cct ctg ccc cat cta cct cca tgc cca gct cct gct gca gcc      562
 Leu Gln Pro Leu Pro His Leu Pro Pro Cys Pro Ala Pro Ala Ala Ala
              35                  40                  45

 tct gcc cca tct acc tcc acg cgc agc tcc tgc tgc agc ctc tgc ccc      610
 Ser Ala Pro Ser Thr Ser Thr Arg Ser Ser Cys Cys Ser Leu Cys Pro
          50                  55                  60

 atc tac ctc cac gcc tgt tcc tgc tgc agc ctc tgc ccc atc tac ctc      658
 Ile Tyr Leu His Ala Cys Ser Cys Cys Ser Leu Cys Pro Ile Tyr Leu
      65                  70                  75

 cac gcc cgg ctc ctg ctg cag cct ctg ccc cat cta cct cca cgc cca      706
 His Ala Arg Leu Leu Leu Gln Pro Leu Pro His Leu Pro Pro Arg Pro
  80                  85                  90                  95

 gct cct gct gca gcc tct gcc cca tct act gcc acg ccc ggc tcc tgc      754
 Ala Pro Ala Ala Ala Ser Ala Pro Ser Thr Ala Thr Pro Gly Ser Cys
                 100                 105                 110

 tgc agc ctc tgc ccc ata tac tgc tat gcc tgg taa ccat aacttccttg      804
 Cys Ser Leu Cys Pro Ile Tyr Cys Tyr Ala Trp 
             115                 120

 gccagaaatc tctctgcccc cttcaggccc ccattttgcc tgtccagacc ccttctagga    864

 ctatttctgc aactcacgta caagtctgaa gttagttcaa ataaaaagtt aaaaaggaaa    924

 gagagaaata gaaaatcact at                                             946




      <210> 278
      <211> 1218
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (95)..(1099)

      <400> 278
 ctcagttcac agctgccctg ttgcagggag gcggtggccc ttctgttgct agaccgagcc     60

 tgtgggatat accaaggcag aggagcccat agcc    atg agg agc ctc ggg gcc     112
                                          Met Arg Ser Leu Gly Ala
                                            1               5

 ctg ctc ttg ctg ctg agc gcc tgc ctg gcg gtg agc gct ggc cct gtg      160
 Leu Leu Leu Leu Leu Ser Ala Cys Leu Ala Val Ser Ala Gly Pro Val
              10                  15                  20

 cca acg ccg ccc gac aac atc caa gtg cag gaa aac ttc aat atc tct      208
 Pro Thr Pro Pro Asp Asn Ile Gln Val Gln Glu Asn Phe Asn Ile Ser
          25                  30                  35

 cgg atc tat ggg aag tgg tac aac ctg gcc atc ggt tcc acc tgc ccc      256
 Arg Ile Tyr Gly Lys Trp Tyr Asn Leu Ala Ile Gly Ser Thr Cys Pro
      40                  45                  50

 tgg ctg aag aag atc atg gac agg atg aca gtg agc acg ctg gtg ctg      304
 Trp Leu Lys Lys Ile Met Asp Arg Met Thr Val Ser Thr Leu Val Leu
  55                  60                  65                  70

 gga gag ggc gct aca gag gcg gag atc agc atg acc agc act cgt tgg      352
 Gly Glu Gly Ala Thr Glu Ala Glu Ile Ser Met Thr Ser Thr Arg Trp
                  75                  80                  85

 cgg aaa ggt gtc tgt gag gag acg tct gga gct tat gag aaa aca gat      400
 Arg Lys Gly Val Cys Glu Glu Thr Ser Gly Ala Tyr Glu Lys Thr Asp
              90                  95                 100

 act gat ggg aag ttt ctc tat cac aaa tcc aaa tgg aac ata acc atg      448
 Thr Asp Gly Lys Phe Leu Tyr His Lys Ser Lys Trp Asn Ile Thr Met
         105                 110                 115

 gag tcc tat gtg gtc cac acc aac tat gat gag tat gcc att ttc ctg      496
 Glu Ser Tyr Val Val His Thr Asn Tyr Asp Glu Tyr Ala Ile Phe Leu
     120                 125                 130

 acc aag aaa ttc agc cgc cat cat gga ccc acc att act gcc aag ctc      544
 Thr Lys Lys Phe Ser Arg His His Gly Pro Thr Ile Thr Ala Lys Leu
 135                 140                 145                 150

 tac ggg cgg gcg ccg cag ctg agg gaa act ctc ctg cag gac ttc aga      592
 Tyr Gly Arg Ala Pro Gln Leu Arg Glu Thr Leu Leu Gln Asp Phe Arg
                 155                 160                 165

 gtg gtt gcc cag ggt gtg ggc atc cct gag gac tcc atc ttc acc atg      640
 Val Val Ala Gln Gly Val Gly Ile Pro Glu Asp Ser Ile Phe Thr Met
             170                 175                 180

 gct gac cga ggt gaa tgt gtc cct ggg gag cag gaa cca gag ccc atc      688
 Ala Asp Arg Gly Glu Cys Val Pro Gly Glu Gln Glu Pro Glu Pro Ile
         185                 190                 195

 tta atc ccg aga gtc cgg agg gct gtg cta ccc caa gaa gag gaa gga      736
 Leu Ile Pro Arg Val Arg Arg Ala Val Leu Pro Gln Glu Glu Glu Gly
     200                 205                 210

 tca ggg ggt ggg caa ctg gta act gaa gtc acc aag aaa gaa gat tcc      784
 Ser Gly Gly Gly Gln Leu Val Thr Glu Val Thr Lys Lys Glu Asp Ser
 215                 220                 225                 230

 tgc cag ctg ggc tac tcg gcc ggt ccc tgc atg gga atg acc agc agg      832
 Cys Gln Leu Gly Tyr Ser Ala Gly Pro Cys Met Gly Met Thr Ser Arg
                 235                 240                 245

 tat ttc tat aat ggt aca tcc atg gcc tgt gag act ttc cag tac ggc      880
 Tyr Phe Tyr Asn Gly Thr Ser Met Ala Cys Glu Thr Phe Gln Tyr Gly
             250                 255                 260

 ggc tgc atg ggc aac ggt aac aac ttc gtc aca gtc cgg ggc ccc tgc      928
 Gly Cys Met Gly Asn Gly Asn Asn Phe Val Thr Val Arg Gly Pro Cys
         265                 270                 275

 cga gcc ttc atc cag ctc tgg gca ttt gat gct gtc aag ggg aag tgc      976
 Arg Ala Phe Ile Gln Leu Trp Ala Phe Asp Ala Val Lys Gly Lys Cys
     280                 285                 290

 gtc ctc ttc ccc tac ggg ggc tgc cag ggc aac ggg aac aag ttc tac     1024
 Val Leu Phe Pro Tyr Gly Gly Cys Gln Gly Asn Gly Asn Lys Phe Tyr
 295                 300                 305                 310

 tca gag aag gag tgc aga gag tac tgc ggt gtc cct ggt gat ggt gat     1072
 Ser Glu Lys Glu Cys Arg Glu Tyr Cys Gly Val Pro Gly Asp Gly Asp
                 315                 320                 325

 gag gag ctg ctg cgc ttc tcc aac tga caact ggccggtctg caagtcagag     1124
 Glu Glu Leu Leu Arg Phe Ser Asn 
             330

 gatggccagt gtctgtcccg gggtcctgtg gcaggcagcg ccaagcaacc tgggtccaaa   1184

 taaaaactaa attgtaaact cctgaaaaaa aaaa                               1218




      <210> 279
      <211> 1255
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (101)..(946)

      <400> 279
 cacagcccag taactttgct agtacctctt gagtgcaagg tggagaatta agatctggat     60

 ttgagacgga gcacggaaca tttcactcag gggaagagct  atg aac atg ctg act     115
                                              Met Asn Met Leu Thr
                                                1               5

 gcc agc ctg ttg agg gca gtc ata gcc tcc atc tgt gtt gta tcc agc      163
 Ala Ser Leu Leu Arg Ala Val Ile Ala Ser Ile Cys Val Val Ser Ser
                  10                  15                  20

 atg gct cag aag gta act caa gcg cag act gaa att tct gtg gtg gag      211
 Met Ala Gln Lys Val Thr Gln Ala Gln Thr Glu Ile Ser Val Val Glu
              25                  30                  35

 aag gag gat gtg acc ttg gac tgt gtg tat gaa acc cgt gat act act      259
 Lys Glu Asp Val Thr Leu Asp Cys Val Tyr Glu Thr Arg Asp Thr Thr
          40                  45                  50

 tat tac tta ttc tgg tac aag caa cca cca agt gga gaa ttg gtt ttc      307
 Tyr Tyr Leu Phe Trp Tyr Lys Gln Pro Pro Ser Gly Glu Leu Val Phe
      55                  60                  65

 ctt att cgt cgg aac tct ttt gat gag caa aat gaa ata agt ggt cgg      355
 Leu Ile Arg Arg Asn Ser Phe Asp Glu Gln Asn Glu Ile Ser Gly Arg
  70                  75                  80                  85

 tat tct tgg aac ttc cag aaa tcc acc agt tcc ttc aac ttc acc atc      403
 Tyr Ser Trp Asn Phe Gln Lys Ser Thr Ser Ser Phe Asn Phe Thr Ile
                  90                  95                 100

 aca gcc tca caa gtc gtg gac tca gca gta tac ttc tgt gct ctg agt      451
 Thr Ala Ser Gln Val Val Asp Ser Ala Val Tyr Phe Cys Ala Leu Ser
             105                 110                 115

 gag gcg gcc caa gaa acc agt ggc tct agg ttg acc ttt ggg gaa gga      499
 Glu Ala Ala Gln Glu Thr Ser Gly Ser Arg Leu Thr Phe Gly Glu Gly
         120                 125                 130

 aca cag ctc aca gtg aat cct gat atc cag aac cct gac cct gcc gtg      547
 Thr Gln Leu Thr Val Asn Pro Asp Ile Gln Asn Pro Asp Pro Ala Val
     135                 140                 145

 tac cag ctg aga gac tct aaa tcc agt gac aag tct gtc tgc cta ttc      595
 Tyr Gln Leu Arg Asp Ser Lys Ser Ser Asp Lys Ser Val Cys Leu Phe
 150                 155                 160                 165

 acc gat ttt gat tct caa aca aat gtg tca caa agt aag gat tct gat      643
 Thr Asp Phe Asp Ser Gln Thr Asn Val Ser Gln Ser Lys Asp Ser Asp
                 170                 175                 180

 gtg tat atc aca gac aaa act gtg cta gac atg agg tct atg gac ttc      691
 Val Tyr Ile Thr Asp Lys Thr Val Leu Asp Met Arg Ser Met Asp Phe
             185                 190                 195

 aag agc aac agt gct gtg gcc tgg agc aac aaa tct gac ttt gca tgt      739
 Lys Ser Asn Ser Ala Val Ala Trp Ser Asn Lys Ser Asp Phe Ala Cys
         200                 205                 210

 gca aac gcc ttc aac aac agc att att cca gaa gac acc ttc ttc ccc      787
 Ala Asn Ala Phe Asn Asn Ser Ile Ile Pro Glu Asp Thr Phe Phe Pro
     215                 220                 225

 agc cca gaa agt tcc tgt gat gtc aag ctg gtc gag aaa agc ttt gaa      835
 Ser Pro Glu Ser Ser Cys Asp Val Lys Leu Val Glu Lys Ser Phe Glu
 230                 235                 240                 245

 aca gat acg aac cta aac ttt caa aac ctg tca gtg att ggg ttc cga      883
 Thr Asp Thr Asn Leu Asn Phe Gln Asn Leu Ser Val Ile Gly Phe Arg
                 250                 255                 260

 atc ctc ctc ctg aaa gtg gcc ggg ttt aat ctg ctc atg acg ctg cgg      931
 Ile Leu Leu Leu Lys Val Ala Gly Phe Asn Leu Leu Met Thr Leu Arg
             265                 270                 275

 ctg tgg tcc agc tga agatctgcaa gactgtaaga cagcctgtgc tccctcgctc      986
 Leu Trp Ser Ser 
         280

 cttccttctg catatgcccc tcttctccct ctccaaacag agggaactct cctaccccca   1046

 aggaggtgaa agctgctacc acctctgtgc ccccccggca atggccacca actggatcct   1106

 acccgaattt atgattaaga tgtgctgaag agctgccaaa cactgctgcc accccctctg   1166

 ttcccttatt gctgcttgtc actgcctgac attcacggca gaggcaagct gctgcagcct   1226

 cccctggctt tgcacattcc ctcctgctc                                     1255




      <210> 280
      <211> 556
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (5)..(556)

      <400> 280
 cacc atg aac atg ctg act gcc agc ctg ttg agg gca gtc ata gcc tcc      49
      Met Asn Met Leu Thr Ala Ser Leu Leu Arg Ala Val Ile Ala Ser
        1               5                  10                  15

 atc tgt gtt gta tcc agc atg gct cag aag gta act caa gcg cag act       97
 Ile Cys Val Val Ser Ser Met Ala Gln Lys Val Thr Gln Ala Gln Thr
                  20                  25                  30

 gaa att tct gtg gtg gag aag gag gat gtg acc ttg gac tgt gtg tat      145
 Glu Ile Ser Val Val Glu Lys Glu Asp Val Thr Leu Asp Cys Val Tyr
              35                  40                  45

 gaa acc cgt gat act act tat tac tta ttc tgg tac aag caa cca cca      193
 Glu Thr Arg Asp Thr Thr Tyr Tyr Leu Phe Trp Tyr Lys Gln Pro Pro
          50                  55                  60

 agt gga gaa ttg gtt ttc ctt att cgt cgg aac tct ttt gat gag caa      241
 Ser Gly Glu Leu Val Phe Leu Ile Arg Arg Asn Ser Phe Asp Glu Gln
      65                  70                  75

 aat gaa ata agt ggt cgg tat tct tgg aac ttc cag aaa tcc acc agt      289
 Asn Glu Ile Ser Gly Arg Tyr Ser Trp Asn Phe Gln Lys Ser Thr Ser
  80                  85                  90                  95

 tcc ttc aac ttc acc atc aca gcc tca caa gtc gtg gac tca gca gta      337
 Ser Phe Asn Phe Thr Ile Thr Ala Ser Gln Val Val Asp Ser Ala Val
                 100                 105                 110

 tac ttc tgt gct ctg agt gag aga gat gac aag atc atc ttt gga aaa      385
 Tyr Phe Cys Ala Leu Ser Glu Arg Asp Asp Lys Ile Ile Phe Gly Lys
             115                 120                 125

 ggg aca cga ctt cat att ctc ccc aat atc cag aac cct gac cct gcc      433
 Gly Thr Arg Leu His Ile Leu Pro Asn Ile Gln Asn Pro Asp Pro Ala
         130                 135                 140

 gtg tac cag ctg aga gac tct aaa tcc agt gac aag tct gtc tgc cta      481
 Val Tyr Gln Leu Arg Asp Ser Lys Ser Ser Asp Lys Ser Val Cys Leu
     145                 150                 155

 ttc acc gat ttt gat tct caa aca aat gtg tca caa agt aag gat tct      529
 Phe Thr Asp Phe Asp Ser Gln Thr Asn Val Ser Gln Ser Lys Asp Ser
 160                 165                 170                 175

 gat gtg tat atc aca gac aaa ctg tgc                                  556
 Asp Val Tyr Ile Thr Asp Lys Leu Cys 
                 180





      <210> 281
      <211> 411
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (101)..(361)

      <400> 281
 gttcgagccc ttggtgggga cagctgggga gatggcagtg caggctggaa cctgggctgc     60

 cccagaacac agtccattac gatagaaaca ctaattgagc  atg tgc gtg ggg tgg     115
                                              Met Cys Val Gly Trp
                                                1               5

 ggg tgt gtg tgc aca tgt gag tgt gag tgt gtg tgg gcg ctt ggt ggg      163
 Gly Cys Val Cys Thr Cys Glu Cys Glu Cys Val Trp Ala Leu Gly Gly
                  10                  15                  20

 ggg ttg ggg aca gct gga agg tgc cag gtg cac ttg ggg ttg ggg ttg      211
 Gly Leu Gly Thr Ala Gly Arg Cys Gln Val His Leu Gly Leu Gly Leu
              25                  30                  35

 gtg tgt tgg gtg ttg aag tgg aat cgt ttc atc cca gcc atg gag gcc      259
 Val Cys Trp Val Leu Lys Trp Asn Arg Phe Ile Pro Ala Met Glu Ala
          40                  45                  50

 acc agc agg agt gtt cat ggg gat gtg ggc gag gtg ggg cac ttt gaa      307
 Thr Ser Arg Ser Val His Gly Asp Val Gly Glu Val Gly His Phe Glu
      55                  60                  65

 gga atg gcg gtc tgc tgg tgc cct cga agg ggc atc ctt cct ggt ctt      355
 Gly Met Ala Val Cys Trp Cys Pro Arg Arg Gly Ile Leu Pro Gly Leu
  70                  75                  80                  85

 cgc tga cccagaggcg ctgtgcctgc atatcatcca ccaccaccct agcccagcct       411
 Arg 






      <210> 282
      <211> 1407
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (22)..(264)

      <400> 282
 gctagaaaag tggttgggta a  atg gaa aga ata tta gcc tca att ctt act      51
                          Met Glu Arg Ile Leu Ala Ser Ile Leu Thr
                            1               5                  10

 tcc ctc aca gct gta atg ggt gta ctt ttt ctt gtc agg tgc tgt gtc       99
 Ser Leu Thr Ala Val Met Gly Val Leu Phe Leu Val Arg Cys Cys Val
                  15                  20                  25

 aca cca tgc atc tgt ggg ttg gtg cag agg ctt ata aaa atg gca ctt      147
 Thr Pro Cys Ile Cys Gly Leu Val Gln Arg Leu Ile Lys Met Ala Leu
              30                  35                  40

 act aaa acc tcc ctt aac tat cct cca cct tat cca gag aag ctt ctt      195
 Thr Lys Thr Ser Leu Asn Tyr Pro Pro Pro Tyr Pro Glu Lys Leu Leu
          45                  50                  55

 ctt ttg gaa aat caa gca aaa caa cta agc caa gac atg tta aaa aaa      243
 Leu Leu Glu Asn Gln Ala Lys Gln Leu Ser Gln Asp Met Leu Lys Lys
      60                  65                  70

 ctt ttg aaa aga aag ctg taa ag aaatacaagg gaaggggttg atatatatga      296
 Leu Leu Lys Arg Lys Leu 
  75                  80

 gttctaaatt tcttttgaaa taatatgtca gtatgttcca ctctttgcct tctactttta    356

 aacttaactt cctcataaag caatcttttt cgattaccca ctccaccctg actcattcca    416

 attacctact ccaccctgac tcacctgctc cactctacat tccaatcacc tgctccaccc    476

 taactcattc caattacctg ctacctgctc tgccctgacc cccgccaaag cactcaccct    536

 gtcctcaatc ttacaactgg agtaattctt cagtagacaa gcttttcggg tgcgcaagtc    596

 tctttggggt tatgttgttc agatcagctt acattttatc tgaaaggttc ttcactcttt    656

 cattatcatg cttcatccac tttctatctt ccagaaatat gctgagatcc tctccactta    716

 taaccaaatc ccttcagttt tctttgctga gatgtgtcag ttcctttttg catttcttga    776

 cttcaatttc agtggggcct ggggagggag ggaaggtaaa cttatgttta ctccattatc    836

 tcaaattaga aattccagtg gaggctttta gacacggaag taacatggat aactttatat    896

 tttaaatata tccccgggat gtactgctaa aaatatatta aagagggcaa ggatggatac    956

 acatattctc aaagatggag gatctaattt cctctctgag aacatgcagt gtttgggatc   1016

 tctgggagtc aggcacttca ctgaaatagt ccatcattca aaatccaaca aactagagaa   1076

 cactttcatg gtaccctaga aagaataact gaaacttgag taatgcagaa cctaaaagat   1136

 ctggctgatg ctaaagggct cactccagaa ctatctattg ggaagcactt gaggagccta   1196

 ccttaaattc tttgaattgt catttgggat aaacaaaatg attttttgtt ctgataaaag   1256

 tagatgatag gtaagtatat gcagccaaag ctctggcaag taggaacata atgatccttt   1316

 ggtttgctgg tcggcttctt tatttaccca ttgatggggt cattcaaagc actgtagtta   1376

 tgaatgccca ttctgtaatc agaatgcctg a                                  1407




      <210> 283
      <211> 476
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (54)..(359)

      <400> 283
 gcgcgtcttt cgggcataca gtgacctcgg gcggcgggtc acgtcggccg ggc   atg      56
                                                              Met
                                                                1

 gct gca tgg agc ccg gcc gcg gca gcg cct ctc ctc cgc ggg atc cgc      104
 Ala Ala Trp Ser Pro Ala Ala Ala Ala Pro Leu Leu Arg Gly Ile Arg
               5                  10                  15

 ggg ctt cca ctt cac cat cgg atg ttt gcc act cag act gag ggg gag      152
 Gly Leu Pro Leu His His Arg Met Phe Ala Thr Gln Thr Glu Gly Glu
          20                  25                  30

 ctc aga gtg acc caa att ctc aaa gaa aag ttt cca cga gct aca gct      200
 Leu Arg Val Thr Gln Ile Leu Lys Glu Lys Phe Pro Arg Ala Thr Ala
      35                  40                  45

 ata aaa gtc act gac att tca ggc act aaa aga aga aat caa aga gat      248
 Ile Lys Val Thr Asp Ile Ser Gly Thr Lys Arg Arg Asn Gln Arg Asp
  50                  55                  60                  65

 gca tgg att gcg gat att tac ctc tgt ccc caa acg ctg acc acg ccc      296
 Ala Trp Ile Ala Asp Ile Tyr Leu Cys Pro Gln Thr Leu Thr Thr Pro
                  70                  75                  80

 tgg ctg cat aga tgc tgc tgc tta aga cct tgg atg aac ttc act gac      344
 Trp Leu His Arg Cys Cys Cys Leu Arg Pro Trp Met Asn Phe Thr Asp
              85                  90                  95

 atc att ctt ccc taa gcagtcacca aaaaatttat atattttgct catatacatt      399
 Ile Ile Leu Pro 
         100

 tccatattat aattatagaa gatgtataat ctatttagat gttaattaaa ggaaacaaac    459

 aactgaaaaa aaaaaaa                                                   476




      <210> 284
      <211> 404
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (246)..(404)

      <400> 284
 ggtgaatcgg gcgcttattg ctcaaggaga ctttagtctt gagttttgag aatttctgat     60

 gatgggatgg gtgaccttgc cttccgttac ggagatttct tgcataagca aataggagct    120

 gacgcccagc tctgctccac gtgaacctgc ctgggaggtg cgcagggagc atcttgcgtg    180

 ggccatggag caggaatcgg ggccacatgg cctcccctct ctttcctcat gggatttctg    240

 ggtga    atg aca gca ggg tgc ttc acc atc ctg agc ctc ggt tta ctc     287
          Met Thr Ala Gly Cys Phe Thr Ile Leu Ser Leu Gly Leu Leu
            1               5                  10

 att tgc aaa aca gga ccg atc ccc tcc acc ccg ccc ttt cca cag gct      335
 Ile Cys Lys Thr Gly Pro Ile Pro Ser Thr Pro Pro Phe Pro Gln Ala
  15                  20                  25                  30

 gac cgt ggg aac ttc atg gga tat cga ata ggg aag tgc att cta aac      383
 Asp Arg Gly Asn Phe Met Gly Tyr Arg Ile Gly Lys Cys Ile Leu Asn
                  35                  40                  45

 tgt aaa gtg ctg tgc aca tga                                          404
 Cys Lys Val Leu Cys Thr 
              50





      <210> 285
      <211> 565
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (173)..(484)

      <400> 285
 tttcgtctac ccccgcggag ttgtcgtgtg ttctggattc attccggcac caccatgtcg     60

 aaggtttcct ttaagatcac gctgacgtcg gacccacggc tgccgtacaa agtgtgagta    120

 gctcggccga gatgggcctt ttggggccgg acaagacggg gctgggttgg gg    atg     175
                                                              Met
                                                                1

 atc cga gcc ttt cca aca act acc cca cgc agt ctt cat ctc ttc act      223
 Ile Arg Ala Phe Pro Thr Thr Thr Pro Arg Ser Leu His Leu Phe Thr
               5                  10                  15

 tca tct act ttc ctg gct cgc gcc ctt cca gga gcc ttt ccc acc gga      271
 Ser Ser Thr Phe Leu Ala Arg Ala Leu Pro Gly Ala Phe Pro Thr Gly
          20                  25                  30

 gcc tgc gag gag aga ctc agt gtt cct gaa agt aca cct ttc aca gca      319
 Ala Cys Glu Glu Arg Leu Ser Val Pro Glu Ser Thr Pro Phe Thr Ala
      35                  40                  45

 gtc tta aag ttt gca gca gaa gaa ttt aaa gtt cct gct gca aca agt      367
 Val Leu Lys Phe Ala Ala Glu Glu Phe Lys Val Pro Ala Ala Thr Ser
  50                  55                  60                  65

 gca att att acc aat gat gga ata gga ata aat cct gca cag act gct      415
 Ala Ile Ile Thr Asn Asp Gly Ile Gly Ile Asn Pro Ala Gln Thr Ala
                  70                  75                  80

 gga aat gtt ttt cta aaa cat ggt tca gaa ctg cgg att att cct aga      463
 Gly Asn Val Phe Leu Lys His Gly Ser Glu Leu Arg Ile Ile Pro Arg
              85                  90                  95

 gat cgt gtt gga agt tgt taa ta tctgctactt ggaacatacg attgcctttc      516
 Asp Arg Val Gly Ser Cys 
         100

 agaataaata ttggtatttt ttgttgttgt aaaaaaaaaa aaaaaaaaa                565




      <210> 286
      <211> 489
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (113)..(469)

      <400> 286
 ggcggcgcgg ggcggaggtc gggtggggaa agctggagcc gcagggaacg cgcaggacag     60

 gctcgctggg tgtcgactct agccctctgt cagagacctt gggacccgcg ca    atg     115
                                                              Met
                                                                1

 tgg cag tgg aag gcg cag ggt ctg acc ccg gcc gcg gcc gcc gca gca      163
 Trp Gln Trp Lys Ala Gln Gly Leu Thr Pro Ala Ala Ala Ala Ala Ala
               5                  10                  15

 gct gat ctg tca acc ccg gcc aga gcc gag ccg cct gag gcc tgc agt      211
 Ala Asp Leu Ser Thr Pro Ala Arg Ala Glu Pro Pro Glu Ala Cys Ser
          20                  25                  30

 gtt ctc cat cac cac tgt gat ggc atc cgc ttc cgt gac tgt cac tgt      259
 Val Leu His His His Cys Asp Gly Ile Arg Phe Arg Asp Cys His Cys
      35                  40                  45

 gca ccc tcc gcc tgt cct ggg ccc acg cag gac ccc caa gcg ggg ctc      307
 Ala Pro Ser Ala Cys Pro Gly Pro Thr Gln Asp Pro Gln Ala Gly Leu
  50                  55                  60                  65

 tgc aca ggc cag gag ggc tac cca ggg act gac cac ggg ttg ttc atg      355
 Cys Thr Gly Gln Glu Gly Tyr Pro Gly Thr Asp His Gly Leu Phe Met
                  70                  75                  80

 ggt cct cac ctg ctt ttc cag gtc cag ggt gag agg acg aat ttg aag      403
 Gly Pro His Leu Leu Phe Gln Val Gln Gly Glu Arg Thr Asn Leu Lys
              85                  90                  95

 gta gaa gtc aca gag ttg cag gat gtg gag tgc gag gag tgg ccc cgg      451
 Val Glu Val Thr Glu Leu Gln Asp Val Glu Cys Glu Glu Trp Pro Arg
         100                 105                 110

 gga agc agc tcc aac tga gggtgattaa aatctgaagc                        489
 Gly Ser Ser Ser Asn 
     115





      <210> 287
      <211> 1775
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (279)..(1253)

      <400> 287
 aaatcttttt tttttttttt tttaccacaa aggaaaaaca cagcatattg aatcatcaca     60

 aggcagccac cccttcatag ccacacccgg cccctggcca ccactgacca gtgctccatc    120

 gccagaattc tgttgtctca ggaatgttca atgaatggaa tcctgtatgg cctgagatga    180

 gtgtctttca tgccacatga cacccttgag gcctgtgcaa gctgatggca tgtcaacagt    240

 tagctgtttc tcattgctga gtagcgattg gtcctgtc    atg gtt tat tca gcc     293
                                              Met Val Tyr Ser Ala
                                                1               5

 atg tgg tgg atg gct act tgt ctt cta tgc cac ttg tct tct gat tgc      341
 Met Trp Trp Met Ala Thr Cys Leu Leu Cys His Leu Ser Ser Asp Cys
                  10                  15                  20

 tgg act gac tct ctc gcc ctc tct tgg tgc agc cct cgg gag gct cgg      389
 Trp Thr Asp Ser Leu Ala Leu Ser Trp Cys Ser Pro Arg Glu Ala Arg
              25                  30                  35

 tca cac tct cca aga gca cag cca tca tct ccc acg gca cca cag gcc      437
 Ser His Ser Pro Arg Ala Gln Pro Ser Ser Pro Thr Ala Pro Gln Ala
          40                  45                  50

 tgg tca cat ggg acg ctg ccc tct acc ttg cag aat ggg ccg aga acc      485
 Trp Ser His Gly Thr Leu Pro Ser Thr Leu Gln Asn Gly Pro Arg Thr
      55                  60                  65

 cag cag cct tca ctc aca ggt gac ctc ggg gcg cag ggc agg gca ccg      533
 Gln Gln Pro Ser Leu Thr Gly Asp Leu Gly Ala Gln Gly Arg Ala Pro
  70                  75                  80                  85

 agg cag gct tac cct ggt gca gtc aca gac acg gtc ccc ttt cct ccc      581
 Arg Gln Ala Tyr Pro Gly Ala Val Thr Asp Thr Val Pro Phe Pro Pro
                  90                  95                 100

 acc agg act gtc cta aag ctt ggc agt ggc gcc ggc ctc aca ggc ctg      629
 Thr Arg Thr Val Leu Lys Leu Gly Ser Gly Ala Gly Leu Thr Gly Leu
             105                 110                 115

 gcc atc tgc aag atg tgc cgc ccc cgg gcg tac atc ttc agc gac tgt      677
 Ala Ile Cys Lys Met Cys Arg Pro Arg Ala Tyr Ile Phe Ser Asp Cys
         120                 125                 130

 cac agc cgg gtc ctc gag cag ctc cga ggg aat gtc ctt ctc aat ggc      725
 His Ser Arg Val Leu Glu Gln Leu Arg Gly Asn Val Leu Leu Asn Gly
     135                 140                 145

 ctc tca tta gag gca gac atc act gcc aac tta gac ggc ccc agg gtg      773
 Leu Ser Leu Glu Ala Asp Ile Thr Ala Asn Leu Asp Gly Pro Arg Val
 150                 155                 160                 165

 aca gtg gcc cag ctg gac tgg gac gtc gcg acg gtc tgt cag ctc tct      821
 Thr Val Ala Gln Leu Asp Trp Asp Val Ala Thr Val Cys Gln Leu Ser
                 170                 175                 180

 gcc gtc cag cca gat gtt gtc att gca gca ggt aat gcc cag ccc cgg      869
 Ala Val Gln Pro Asp Val Val Ile Ala Ala Gly Asn Ala Gln Pro Arg
             185                 190                 195

 gca tcc tgt gca ggc ggt gtc ctt gca gct cta acc agc tct tgg ctc      917
 Ala Ser Cys Ala Gly Gly Val Leu Ala Ala Leu Thr Ser Ser Trp Leu
         200                 205                 210

 gta gac gtg ctg tat tgc cca gaa gcc atc gtg tcg cta gtc ggg gtc      965
 Val Asp Val Leu Tyr Cys Pro Glu Ala Ile Val Ser Leu Val Gly Val
     215                 220                 225

 ctg cgg agg ctg gct gcc tgc cgg gag cac cag cgg gct cct gag gtc     1013
 Leu Arg Arg Leu Ala Ala Cys Arg Glu His Gln Arg Ala Pro Glu Val
 230                 235                 240                 245

 tac gtg gcc ttt acc gtc cac aac cca cag acg tgc cag ctg ttc acc     1061
 Tyr Val Ala Phe Thr Val His Asn Pro Gln Thr Cys Gln Leu Phe Thr
                 250                 255                 260

 act gag cta gtt gag tcc cca cgc cca ccc ggg cct gca tgg tcc ccg     1109
 Thr Glu Leu Val Glu Ser Pro Arg Pro Pro Gly Pro Ala Trp Ser Pro
             265                 270                 275

 agc tgt ccc tgc agg act cca gtg gaa gtg aaa gaa ctg ggc gcc ggc     1157
 Ser Cys Pro Cys Arg Thr Pro Val Glu Val Lys Glu Leu Gly Ala Gly
         280                 285                 290

 gta aag cta gca tgc ccc aca ctc cca cac cat gcg ggg aac tcg ggc     1205
 Val Lys Leu Ala Cys Pro Thr Leu Pro His His Ala Gly Asn Ser Gly
     295                 300                 305

 aga ggc cgg cca ggc cag gat cag atg gga agt gga agc ttg tca tga     1253
 Arg Gly Arg Pro Gly Gln Asp Gln Met Gly Ser Gly Ser Leu Ser 
 310                 315                 320

 ccagaaactg tttccctaca aagagcactt ggagatggca atgctgaacc taatactgta   1313

 ggactcacac acgacttcaa cgggattgtg aggatccagt cacctctcat gggaagaatt   1373

 tttacatggg aaagcggata aactttcatt ggactgaatg ttggagaatg ttaatttccc   1433

 aatcagggac cacaaactgc cctctattag acatccggct atctaaggcg tgtgggtgcc   1493

 cctttctgca gccagtctgg tctaagaaat caccctaatc gacttgaaat ctggtccaaa   1553

 tagctttctt gtgcaataca cgttggttca gtaacaaaaa aaaaaacccg ggctttcggc   1613

 gggaaggtat aagggaatgc atatgttccg cccgttttgg aaggaatcgc gcccataggg   1673

 ggaatgaacc gtcggaatac actgaaaaaa aaaaagagag aagacacaaa aacaagaata   1733

 aacacacaaa gaaacaaaaa gtgaaggaag tagagcacaa gg                      1775




      <210> 288
      <211> 906
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (164)..(361)

      <220>
      <221> misc_feature
      <222> (1)...(906)
      <223> n = a,t,c or g

      <400> 288
 taagcttgcg gccgcctttt tttttttttt tttttttggc cttttaatag ttttattaat     60

 atatttagaa aaacaatccc ttaaaacatt ggtctagatg atattttaac acatacgctt    120

 aatgaaaata tgtatataca tataatgttt taattaggtt cct  atg ttt cag atg     175
                                                  Met Phe Gln Met
                                                    1

 cct ttt gtc tct att ttt tta atc att att ttt tta gag atg gga tct      223
 Pro Phe Val Ser Ile Phe Leu Ile Ile Ile Phe Leu Glu Met Gly Ser
   5                  10                  15                  20

 tgt tac att gcc cag gct ggt ctt gaa ctc ctg gga tca agc gat cct      271
 Cys Tyr Ile Ala Gln Ala Gly Leu Glu Leu Leu Gly Ser Ser Asp Pro
                  25                  30                  35

 cct gcc ttg gcc tcc caa agt gct ggg att ata ggc atg aac caa cgt      319
 Pro Ala Leu Ala Ser Gln Ser Ala Gly Ile Ile Gly Met Asn Gln Arg
              40                  45                  50

 gcc cag cct cag atg cct ttt gga tgg tat atc act aac taa aaattaa      368
 Ala Gln Pro Gln Met Pro Phe Gly Trp Tyr Ile Thr Asn 
          55                  60                  65

 gtgccttgat attataaaat tctaaatttt ttcctattta aaacaatcat acagcacttt    428

 gggaggttga ggcaggagga ctgcttgagc ccaggcatct gagaccagtc tggccaacat    488

 agtgagacac catctctaca gaaaaatttt aaaacttagc caggtgtggt catgcccacc    548

 tgtggtccta gctactttgg aggttaaggc angagatcac ttgagctcan gaggttgagg    608

 gctcggtgag ctatgatcac atgcctgcac ttcaacctga gcacagagtg agactctcct    668

 tnaaangata naaatacatt cttagtaagt actagtgtat atatataatt tctagataac    728

 aggctcgtgc ggattcttgg ctcagggcca atcccctata ggagcgatta atcggaatat    788

 gcttattgtt ctttgtgaat gtatcggtcc aatcccccct acaaccggaa actaaggtaa    848

 acctgggggc tatgagagta tccattaatt gtggctacct gcgcttcatg gaaaattt      906




      <210> 289
      <211> 925
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (58)..(666)

      <400> 289
 ttcgctgtcg acgatttcgt cctagtcctc cggctccgac agctgggtgt ccaggcc        57                                                                 
 atg ggg cag ccc tgg gcg gct ggg agc acg gac ggg gcg ccc gcg cag      105
 Met Gly Gln Pro Trp Ala Ala Gly Ser Thr Asp Gly Ala Pro Ala Gln
   1               5                  10                  15

 ctg cct ctc gtg ctc acc gcg ctg tgg gcc gcg gcc gtg ggc ctg gag      153
 Leu Pro Leu Val Leu Thr Ala Leu Trp Ala Ala Ala Val Gly Leu Glu
              20                  25                  30

 ctg gct tac gtg ctg gtg ctc ggt ccc ggg ccg ccg ccg ctg gga ccc      201
 Leu Ala Tyr Val Leu Val Leu Gly Pro Gly Pro Pro Pro Leu Gly Pro
          35                  40                  45

 ctg gcc cgg gcc ttg cag ctg gcg ctg gcc gcc ttc cag ctg ctc aac      249
 Leu Ala Arg Ala Leu Gln Leu Ala Leu Ala Ala Phe Gln Leu Leu Asn
      50                  55                  60

 ctg ctg ggc aac gtg ggg ctc ttc ctg cgc tcg gat ccc agc atc cgt      297
 Leu Leu Gly Asn Val Gly Leu Phe Leu Arg Ser Asp Pro Ser Ile Arg
  65                  70                  75                  80

 ggc gtg atg ctg gcc ggc cgc ggt ctg ggc cag ggc tgg gct tac tgc      345
 Gly Val Met Leu Ala Gly Arg Gly Leu Gly Gln Gly Trp Ala Tyr Cys
                  85                  90                  95

 tac caa tgc caa agc cag gtg ccg cca cgc agc gga cac tgc tct gcc      393
 Tyr Gln Cys Gln Ser Gln Val Pro Pro Arg Ser Gly His Cys Ser Ala
             100                 105                 110

 tgc cgc gtc tgc atc ctg cgt cgg gac cac cac tgc cgc ctg ctg ggc      441
 Cys Arg Val Cys Ile Leu Arg Arg Asp His His Cys Arg Leu Leu Gly
         115                 120                 125

 cgc tgc gtg ggc ttc ggc aac tac cgg ccc ttc ctg tgc ctg ctg ctt      489
 Arg Cys Val Gly Phe Gly Asn Tyr Arg Pro Phe Leu Cys Leu Leu Leu
     130                 135                 140

 cat gcc gcc ggc gtc ctg ctc cac gtc tct gtg ctg ctg ggc cct gca      537
 His Ala Ala Gly Val Leu Leu His Val Ser Val Leu Leu Gly Pro Ala
 145                 150                 155                 160

 ctg tcg gcc ctg ctg cga gcc cac acg ccc ctc cac atg gct gcc ctc      585
 Leu Ser Ala Leu Leu Arg Ala His Thr Pro Leu His Met Ala Ala Leu
                 165                 170                 175

 ctc ctg ctt ccc tgg ctc atg ttg ctc aca gca cct tcc agc ctg agg      633
 Leu Leu Leu Pro Trp Leu Met Leu Leu Thr Ala Pro Ser Ser Leu Arg
             180                 185                 190

 aac agt gat ttg cag gca acg tgt acc tcc tag gctgtccc tggatttgca      684
 Asn Ser Asp Leu Gln Ala Thr Cys Thr Ser 
         195                 200

 gagatggagt ctcgctctgt tgtccaggct gaagtgccat ggtttgatct tggctcactg    744

 caacctccgc ctcccaggct caagcgattc tcctacctcg acctcctgag tagctgggat    804

 tacagcctta aagcccactc tcatcttgca agcctctgaa gccaccagtt ttctgagatg    864

 ttcctcccgg ccccggagac cacggatgtg gctaccttct cagaatatag atgtttccat    924

 t                                                                    925




      <210> 290
      <211> 748
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (1)..(549)

      <400> 290
  atg gcg gcc gtg gcg ctg gcg agc ggg aca cgc ctc ggc ctt gtc ctc      48
  Met Ala Ala Val Ala Leu Ala Ser Gly Thr Arg Leu Gly Leu Val Leu
    1               5                  10                  15

 gag ctg ctc ccg gga cag ccc gcg ctg ccc cgg gcg cgc cgg gag tca       96
 Glu Leu Leu Pro Gly Gln Pro Ala Leu Pro Arg Ala Arg Arg Glu Ser
              20                  25                  30

 gtg acc ttc gag gat gtg gcc gtc tac ttc tct gag aac gaa tgg atc      144
 Val Thr Phe Glu Asp Val Ala Val Tyr Phe Ser Glu Asn Glu Trp Ile
          35                  40                  45

 ggc ctg ggc cct gct cag aga gcc ctg tac agg gat gtg atg ctg gag      192
 Gly Leu Gly Pro Ala Gln Arg Ala Leu Tyr Arg Asp Val Met Leu Glu
      50                  55                  60

 aat tat ggg gct gtg gct tcc ctg gca gca ttc cca ttt ccg aaa ccg      240
 Asn Tyr Gly Ala Val Ala Ser Leu Ala Ala Phe Pro Phe Pro Lys Pro
  65                  70                  75                  80

 gct ctg att tcc cag ctg gag cga ggg gaa aca ccc tgg tgc tcg gtt      288
 Ala Leu Ile Ser Gln Leu Glu Arg Gly Glu Thr Pro Trp Cys Ser Val
                  85                  90                  95

 cct cgg gga gct ctg gat gga gag gcc cca agg ggc atc tcc tca gta      336
 Pro Arg Gly Ala Leu Asp Gly Glu Ala Pro Arg Gly Ile Ser Ser Val
             100                 105                 110

 gaa aag agc tgg gct ccc tca ctg ttt cct ggc aca cgg tat gat att      384
 Glu Lys Ser Trp Ala Pro Ser Leu Phe Pro Gly Thr Arg Tyr Asp Ile
         115                 120                 125

 gag ttc cat gat tat gca tgt acc ttg ggt tac aac ccc cct ggc ggc      432
 Glu Phe His Asp Tyr Ala Cys Thr Leu Gly Tyr Asn Pro Pro Gly Gly
     130                 135                 140

 aga acc tct att gtg tcc ttc ttt gta ttg ccc aca gag cct gtt ggt      480
 Arg Thr Ser Ile Val Ser Phe Phe Val Leu Pro Thr Glu Pro Val Gly
 145                 150                 155                 160

 gac ctg cac aca gga gcc ctc cag tca gta ctg att gaa tta ctc aag      528
 Asp Leu His Thr Gly Ala Leu Gln Ser Val Leu Ile Glu Leu Leu Lys
                 165                 170                 175

 gct gcc tct ctg caa agt tga gg taagcagctg agttcaatga tgctggctgc      581
 Ala Ala Ser Leu Gln Ser 
             180

 attttcagct attggggctg cagtagctag gcaggggctg caggcccttc tggcttttta    641

 gccctcctgc tcacccacca tttacacagt cttcctttca gagcccccct ttctcctcct    701

 gcacttcctt gaatattgac tgcctctctg atttccctcg caaactg                  748




      <210> 291
      <211> 729
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (194)..(697)

      <400> 291
 cgctccccgg gtgtggagca cggggagtcg ggcgtggggc gggcagggag tggagtcggg     60

 gtcttactcc ggtggctgca gggcgcaggg tagccgtgtc aggcctgccc aggtgcagag    120

 cgctcctccg cgaccccaac agcctctggt ccggtctggc gcgccctcgc tttcccagag    180

 ggcgacctgg gct   atg gcg gcc gtg gcg ctg gcg agc ggg aca cgc ctc     229
                  Met Ala Ala Val Ala Leu Ala Ser Gly Thr Arg Leu
                    1               5                  10

 ggc ctt gtc ctc gag ctg ctc ccg gga cag ccc gcg ctg ccc cgg gcg      277
 Gly Leu Val Leu Glu Leu Leu Pro Gly Gln Pro Ala Leu Pro Arg Ala
          15                  20                  25

 cgc cgg gag tca gtg acc ttc gag gat gtg gcc gtc tac ttc tct gag      325
 Arg Arg Glu Ser Val Thr Phe Glu Asp Val Ala Val Tyr Phe Ser Glu
      30                  35                  40

 aac gaa tgg atc ggc ctg ggc cct gct cag aga gcc ctg tac agg gat      373
 Asn Glu Trp Ile Gly Leu Gly Pro Ala Gln Arg Ala Leu Tyr Arg Asp
  45                  50                  55                  60

 gtg atg ctg gag aat tat ggg gct gtg gct tcc ctg gca gca ttt cca      421
 Val Met Leu Glu Asn Tyr Gly Ala Val Ala Ser Leu Ala Ala Phe Pro
                  65                  70                  75

 ttt ccc aaa ccg gct ctg att tcc cag ctg gag cga ggg gaa aca ccc      469
 Phe Pro Lys Pro Ala Leu Ile Ser Gln Leu Glu Arg Gly Glu Thr Pro
              80                  85                  90

 tgg tgc tcg gtt cct cgg gga gct ctg gat gga gag gcc cca agg ggc      517
 Trp Cys Ser Val Pro Arg Gly Ala Leu Asp Gly Glu Ala Pro Arg Gly
          95                 100                 105

 atc tcc tca ggg gag att ctc aag ctt cca ggt gct acc ata tgg agc      565
 Ile Ser Ser Gly Glu Ile Leu Lys Leu Pro Gly Ala Thr Ile Trp Ser
     110                 115                 120

 cta agg ata aag cca ata cca aag aaa aca gtg act aaa cag aga gaa      613
 Leu Arg Ile Lys Pro Ile Pro Lys Lys Thr Val Thr Lys Gln Arg Glu
 125                 130                 135                 140

 act agg tcc ttg gtg aca tct ttt gag cca cta gac caa gct tta cct      661
 Thr Arg Ser Leu Val Thr Ser Phe Glu Pro Leu Asp Gln Ala Leu Pro
                 145                 150                 155

 gaa gca gag cta cct cag aac ttt tca gct atg tga gcca ataaacatct      711
 Glu Ala Glu Leu Pro Gln Asn Phe Ser Ala Met 
             160                 165

 gtcaaacgaa aaaaaaaa                                                  729




      <210> 292
      <211> 756
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (114)..(500)

      <220>
      <221> misc_feature
      <222> (1)...(756)
      <223> n = a,t,c or g

      <400> 292
 cctcgtagac cactaggcca tgtggtggaa ttccgaaatt ctgtctctaa ataaataaat     60

 aaattcacca atggctcctc atagatctca ggagaaagtc taaagttccc aac   atg     116
                                                              Met
                                                                1

 gcc tgc agg gtc ctg caa ggt ctc ccc ttt gcc tgc ctg tcc agc ccc      164
 Ala Cys Arg Val Leu Gln Gly Leu Pro Phe Ala Cys Leu Ser Ser Pro
               5                  10                  15

 atc tgt tcc cac ttt gcc ctt act ctt gat cat tct ctc ctg tgc ctg      212
 Ile Cys Ser His Phe Ala Leu Thr Leu Asp His Ser Leu Leu Cys Leu
          20                  25                  30

 aac ttt ttc ttc aac cct tat ccc ctt ctg cct aac ttt tac tta ttt      260
 Asn Phe Phe Phe Asn Pro Tyr Pro Leu Leu Pro Asn Phe Tyr Leu Phe
      35                  40                  45

 ggc aag ttc cag ctc aga att cct tcc tct gga aag cct ttt ctg act      308
 Gly Lys Phe Gln Leu Arg Ile Pro Ser Ser Gly Lys Pro Phe Leu Thr
  50                  55                  60                  65

 ttc gaa gac cag gac cct gct ggg atc ttt gag ctt gtg gag gtg gtc      356
 Phe Glu Asp Gln Asp Pro Ala Gly Ile Phe Glu Leu Val Glu Val Val
                  70                  75                  80

 ggc aat gga acc tac gga cag gtg tac aag gtg aga cga atg gtg tgg      404
 Gly Asn Gly Thr Tyr Gly Gln Val Tyr Lys Val Arg Arg Met Val Trp
              85                  90                  95

 aag tat gac ctc cac atc tgc agg gca gtc ttg gga gga gtg gaa gga      452
 Lys Tyr Asp Leu His Ile Cys Arg Ala Val Leu Gly Gly Val Glu Gly
         100                 105                 110

 agt aga ttc ctg gtc tgc agg tct gaa ggg ggc tat ggg aga tgc tag      500
 Ser Arg Phe Leu Val Cys Arg Ser Glu Gly Gly Tyr Gly Arg Cys 
     115                 120                 125

 agtctagggc cctggaaagg tagagtgggg agaggaaaga gcacccagaa ggaggtactg    560

 ttgatgcctc tctctacctg agtgcagagc cagtcccaga catggtggga acaggccagc    620

 agccaagcag ggtggcctgc agcagtgaga gcaggtggaa gggcatacgg ccttgtgtgt    680

 canaactctc cttggattca aagagagcta aggccaaaga tgtgggtttg ccccttccca    740

 gaccacaaga gaccaa                                                    756




      <210> 293
      <211> 976
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (91)..(810)

      <400> 293
 ataaacttgt tttaaattgg cttattgctg gtctctcaag gcttcctatt tttgtttgct     60

 ttagtctctc taaaatttca gggaaaaact     atg agt ctc aaa atg ctt ata     111
                                      Met Ser Leu Lys Met Leu Ile
                                        1               5

 agc agg aac aag ctg att tta cta cta gga ata gtc ttt ttt gaa cga      159
 Ser Arg Asn Lys Leu Ile Leu Leu Leu Gly Ile Val Phe Phe Glu Arg
          10                  15                  20

 ggt aaa tct gca act ctt tcg ctc ccc aaa gct ccc agt tgt ggg cag      207
 Gly Lys Ser Ala Thr Leu Ser Leu Pro Lys Ala Pro Ser Cys Gly Gln
      25                  30                  35

 agt ctg gtt aag gta cag cct tgg aat tat ttt aac att ttc agt cgc      255
 Ser Leu Val Lys Val Gln Pro Trp Asn Tyr Phe Asn Ile Phe Ser Arg
  40                  45                  50                  55

 att ctt gga gga agc caa gtg gag aag ggt tcc tat ccc tgg cag gta      303
 Ile Leu Gly Gly Ser Gln Val Glu Lys Gly Ser Tyr Pro Trp Gln Val
                  60                  65                  70

 tct ctg aaa caa agg cag aag cat att tgt gga gga agc atc gtc tca      351
 Ser Leu Lys Gln Arg Gln Lys His Ile Cys Gly Gly Ser Ile Val Ser
              75                  80                  85

 cca cag tgg gtg atc acg gcg gct cac tgc att gca aac aga aac att      399
 Pro Gln Trp Val Ile Thr Ala Ala His Cys Ile Ala Asn Arg Asn Ile
          90                  95                 100

 gtg tct act ttg aat gtt act gct gga gag tat gac tta agc cag aca      447
 Val Ser Thr Leu Asn Val Thr Ala Gly Glu Tyr Asp Leu Ser Gln Thr
     105                 110                 115

 gac cca gga gag caa act ctc act att gaa act gtc atc ata cat cca      495
 Asp Pro Gly Glu Gln Thr Leu Thr Ile Glu Thr Val Ile Ile His Pro
 120                 125                 130                 135

 cat ttc tcc acc aag aaa cca atg gac tat gat att gcc ctt ttg aag      543
 His Phe Ser Thr Lys Lys Pro Met Asp Tyr Asp Ile Ala Leu Leu Lys
                 140                 145                 150

 atg gct gga gcc ttc caa ttt ggc cac ttt gtg ggg ccc ata tgt ctt      591
 Met Ala Gly Ala Phe Gln Phe Gly His Phe Val Gly Pro Ile Cys Leu
             155                 160                 165

 cca gag ctg cgg gag caa ttt gag gct ggt ttt att tgt aca act gca      639
 Pro Glu Leu Arg Glu Gln Phe Glu Ala Gly Phe Ile Cys Thr Thr Ala
         170                 175                 180

 ggc tgg ggc cgc tta act gaa ggt ggc gtc ctc tca caa gtc ttg ctc      687
 Gly Trp Gly Arg Leu Thr Glu Gly Gly Val Leu Ser Gln Val Leu Leu
     185                 190                 195

 agt gtg tat tta tgc aag agt gat gct ttc agc ttt ttg gaa acg act      735
 Ser Val Tyr Leu Cys Lys Ser Asp Ala Phe Ser Phe Leu Glu Thr Thr
 200                 205                 210                 215

 ctt tgc tgg aca ccg atg atg ccc gcc tgg cgg atg gtt agc aaa gca      783
 Leu Cys Trp Thr Pro Met Met Pro Ala Trp Arg Met Val Ser Lys Ala
                 220                 225                 230

 gct tct gga ccc cag cgg cac aca tga cattc tcaggaggtg gcgcacgcag      835
 Ala Ser Gly Pro Gln Arg His Thr 
             235

 cagcaaaccg gtaccttggc atcctggtgg ctgcgggaag ccaaagcaat ctgcctggcc    895

 agcttcaggg cttctatccg catgatggca aactctaact cctcctgccc acagggagtg    955

 tgggcaaacc gcagggaaat c                                              976




      <210> 294
      <211> 943
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (560)..(916)

      <220>
      <221> misc_feature
      <222> (1)...(943)
      <223> n = a,t,c or g

      <400> 294
 caccattacc cctccataaa gctagcggtc tcagatctcc acccttgagg gcatccagcc     60

 catttctgtt ttttctttta tcgagtccag gttttcattc aggtaattgt acatntccat    120

 gcagtagtaa gaaataacac agcaagatcc cttacacact ttgcctagtt atccccatgt    180

 taacatttta caaagctata gtgtaatacc ataaccatga tatttacgtt atcgatccac    240

 tagttttatt cagatttttc cagtgttact tatactcatt tgtccctgct tgcaagtgtg    300

 tgtggactaa gttctataca attttatcac ctttgtagat tcgtgtatcc acctaccaca    360

 ggcaagttat taaacagttt caacacctgg aggacctcgt gttgcccatt tataaacacc    420

 ccttcttaaa ccttggcatc cattttgtcc atcatttcta aaatgttatc atttcagaac    480

 tgcaatatag gtggatgcca acatgatccc catggagcta ccatagctaa cggtgcctac    540

 gccaccagga gcatctaac atg ggc acg gct aag gct aac cac tgg gcg tgg     592
                      Met Gly Thr Ala Lys Ala Asn His Trp Ala Trp
                        1               5                  10

 ctg ctg gtg ctc aga ttc gtg ttt gga tgc aat gtc ctt cag atc ctc      640
 Leu Leu Val Leu Arg Phe Val Phe Gly Cys Asn Val Leu Gln Ile Leu
              15                  20                  25

 ctc ccg tcc ttc tca tcc ttc atg tcc agg gtg cag cgc aag gat gca      688
 Leu Pro Ser Phe Ser Ser Phe Met Ser Arg Val Gln Arg Lys Asp Ala
          30                  35                  40

 gaa cag gag tcg cag acc aaa gca gag atc cag gat atg aag caa gag      736
 Glu Gln Glu Ser Gln Thr Lys Ala Glu Ile Gln Asp Met Lys Gln Glu
      45                  50                  55

 tta tcc gcg gtc aat atg atg gac aag ttt gcc aga tct gcc agg ctg      784
 Leu Ser Ala Val Asn Met Met Asp Lys Phe Ala Arg Ser Ala Arg Leu
  60                  65                  70                  75

 gaa aga aag atc aac aag atg atg aat aag ctc aaa act cat gtg aaa      832
 Glu Arg Lys Ile Asn Lys Met Met Asn Lys Leu Lys Thr His Val Lys
                  80                  85                  90

 gta cag aca gct caa tca gga atg cta aaa tgg gtt ata agt gtt gct      880
 Val Gln Thr Ala Gln Ser Gly Met Leu Lys Trp Val Ile Ser Val Ala
              95                 100                 105

 ttc tac aaa ttg cca ggt acc gtg atc agg cta taa ggca gtcttgtggg      930
 Phe Tyr Lys Leu Pro Gly Thr Val Ile Arg Leu 
         110                 115

 gttatccatt act                                                       943




      <210> 295
      <211> 1966
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (1687)..(1932)

      <400> 295
 atggcgcgct gcgagaggct gcgcggagcg gccctgcgcg acgtgctggg ccgggcgcag     60

 ggggtcctgt tcgactgtga cggggtgctg tggaacggcg agcgcgccgt gccgggcgcc    120

 ccggagctgc tggagcggct ggcgcgggcc ggcaaggcgg ctctgtttgt gagcaacaac    180

 agccggcgcg cgcggcccga gctggccctg cgcttcgcgc gcctcggctt cggggggctg    240

 cgcgccgagc agctcttcag ctccgcgctg tgcgccgcgc gcctgctgcg ccagcgcctg    300

 cccgggcctc cggacgcgcc gggcgccgtg ttcgtgctgg gcggcgaggg gctgcgcgcc    360

 gagctgcgcg ccgcggggct gcgcctggcc ggggacccga gcgcggggga cggcgcggcc    420

 ccgcgcgtgc gcgccgtgct tgtgggctac gacgagcact tctccttcgc caagctgagg    480

 gaggcgtgcg cgcacctgcg cgaccccgag tgcctactcg tggccaccga ccgtgaccca    540

 tggcacccgc tgagcgacgg cagccggacc cctggcaccg ggagcctggc cgctgcagtg    600

 gagacagcct cgggacgcca ggccctggtg gtgggcaagc ccagccccta catgttcgag    660

 tgcatcacgg agaacttcag catcgacccc gcacgcacgc ttatggtggg tgaccgcctg    720

 gagaccgaca tcctctttgg ccaccgctgc ggcatgacca ctgtgctcac gctcacagga    780

 gtctcccgcc tagaagaggc ccaggcctac ctagcggccg gccagcacga cctcgtgccc    840

 cattactatg tggagagcat cgcagacttg acagaggggt tggaggactg agcccactgc    900

 acctgcaggc cacaggccca cccctcccca ctccctgatc ccgtaggtgg aggcgatggg    960

 tcacgagcca tgttaagcac aaccggctcc ttggtccagt tctgcaccgg ggtggggctg   1020

 ggacccgggg aaggtttgag ggcccttgca accccctccc agcagtggct gggcactctt   1080

 tgctgcccca gaagctggtc ccctatggat tcatcttggc ctgacccagc caggtggcct   1140

 tatttcttcc ctgtcacctc ccctccttga aatctgggcc ctggtgcctg ctgaagattc   1200

 cctctatccc tgagtactta gtcttctccc ccttccctgg ggcttctaga gctctctctg   1260

 cccctcaggt cctggccctt gggtccttgt caaccagagg tctagggaac cacaaccctt   1320

 attgtcctgg gtggaccaat ccaaaggcta agtgatagtg actcatcaat gttgggtcct   1380

 gtggggtacc agtttaggtt cctaagtaat agtgaccctt tcacgtcctg gagcccgagt   1440

 ggaccaatcg gaagcctaag tgacgatgac cctcgcatgt cctaggtccc tgggtggacc   1500

 catcaggacc ccaagtgata gtgacccagt ggtcttttag atcctcagta gaacagtcca   1560

 gaagcctgag agacagtggc cccttgataa tctgggtctc acgggaccag ctaggggtcc   1620

 aggtttcagt cagtaaataa gagtggtcca cgtcctaaag acacctctcc tttacaaaga   1680

 cttgtg   atg ctc tgg ggc ttc tgt ggc caa gcc cca ccc ttt cct ggt    1728
          Met Leu Trp Gly Phe Cys Gly Gln Ala Pro Pro Phe Pro Gly
            1               5                  10

 cat ggt acc cgt aca gcg ttg atg gcc aca gct cga agg ggg gct ttc     1776
 His Gly Thr Arg Thr Ala Leu Met Ala Thr Ala Arg Arg Gly Ala Phe
  15                  20                  25                  30

 gtg tcc ccc tgt gcg gtc agt gtt ttc agt acc acc tct ctc ccg tgc     1824
 Val Ser Pro Cys Ala Val Ser Val Phe Ser Thr Thr Ser Leu Pro Cys
                  35                  40                  45

 cca ctt ggc tat tta ctt att tat tta ttg tgt gcc agt gat ggt ggg     1872
 Pro Leu Gly Tyr Leu Leu Ile Tyr Leu Leu Cys Ala Ser Asp Gly Gly
              50                  55                  60

 tgg ggg ctg ggc ctt ccc cgc cac ctc cac ccc tgt tgt gac ctg tcc     1920
 Trp Gly Leu Gly Leu Pro Arg His Leu His Pro Cys Cys Asp Leu Ser
          65                  70                  75

 ttc cgt act taa taaagtgcgc gtgggagtgt taaaaaaaaa aaaa               1966
 Phe Arg Thr 
      80





      <210> 296
      <211> 2488
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (1)..(1476)

      <400> 296
  atg cat gct gca gcc aat cag acc cct ggt agc aga gcc tgg gcc cac      48
  Met His Ala Ala Ala Asn Gln Thr Pro Gly Ser Arg Ala Trp Ala His
    1               5                  10                  15

 caa agg caa tgc gga gta cag ggc ctg ctg gtc ctc tgg tca cac cca       96
 Gln Arg Gln Cys Gly Val Gln Gly Leu Leu Val Leu Trp Ser His Pro
              20                  25                  30

 ctc atg ctg gtc tcc aca tac cct tct gtg tcc cca gaa gtc gac agt      144
 Leu Met Leu Val Ser Thr Tyr Pro Ser Val Ser Pro Glu Val Asp Ser
          35                  40                  45

 gtg ggg agt tgg agt gac cca gct gga tgt gac ccc caa gac aga atg      192
 Val Gly Ser Trp Ser Asp Pro Ala Gly Cys Asp Pro Gln Asp Arg Met
      50                  55                  60

 gtg ctg gac tcg ggg tct cag gcg tat gat cag gca ccc acc agc cca      240
 Val Leu Asp Ser Gly Ser Gln Ala Tyr Asp Gln Ala Pro Thr Ser Pro
  65                  70                  75                  80

 cct acc agt ctg ctg tcc ctg cgt cat agg ctg aag cac tca gac cga      288
 Pro Thr Ser Leu Leu Ser Leu Arg His Arg Leu Lys His Ser Asp Arg
                  85                  90                  95

 gat ggg cca cca ctg tac ccc tgg tct cag tcc ctg gcc ttg ccc gtg      336
 Asp Gly Pro Pro Leu Tyr Pro Trp Ser Gln Ser Leu Ala Leu Pro Val
             100                 105                 110

 gct ctg gca gtc ccc cca gca ctg cag ccc cag cct gag cag cag tcg      384
 Ala Leu Ala Val Pro Pro Ala Leu Gln Pro Gln Pro Glu Gln Gln Ser
         115                 120                 125

 ttc tca cag atg cac ctg ggc cac ggc ggc cac atg cgt cgc agt gag      432
 Phe Ser Gln Met His Leu Gly His Gly Gly His Met Arg Arg Ser Glu
     130                 135                 140

 agc acc tac tct gta aat agt act ggc cgg cgg ggg cgt ggc acc ctg      480
 Ser Thr Tyr Ser Val Asn Ser Thr Gly Arg Arg Gly Arg Gly Thr Leu
 145                 150                 155                 160

 gga cag cct cca cct gga cgg cga tgg aac cca ggt ggg cgc acc ctg      528
 Gly Gln Pro Pro Pro Gly Arg Arg Trp Asn Pro Gly Gly Arg Thr Leu
                 165                 170                 175

 cgg cct gca gcc tcc ctg cct cac att act aag act caa agc gat gca      576
 Arg Pro Ala Ala Ser Leu Pro His Ile Thr Lys Thr Gln Ser Asp Ala
             180                 185                 190

 ggc cat agt gcc agc aag agc ccc tgc atg ttg gtg gcc ctg cgg cca      624
 Gly His Ser Ala Ser Lys Ser Pro Cys Met Leu Val Ala Leu Arg Pro
         195                 200                 205

 acc aac ttc gag tac cag gag ccc atg cct atg gct gtg ctg aag tac      672
 Thr Asn Phe Glu Tyr Gln Glu Pro Met Pro Met Ala Val Leu Lys Tyr
     210                 215                 220

 tgc gag gcc tct gga cag ttc atc cat cag gca gtt ggc atc att gag      720
 Cys Glu Ala Ser Gly Gln Phe Ile His Gln Ala Val Gly Ile Ile Glu
 225                 230                 235                 240

 gct gtt ctg gag aag ttt gga acc tac gaa cac ttt gag gct gcc acc      768
 Ala Val Leu Glu Lys Phe Gly Thr Tyr Glu His Phe Glu Ala Ala Thr
                 245                 250                 255

 ggc agg cag ctg ctc acc aag tgc cag ata tgg tcc att gtg gag tta      816
 Gly Arg Gln Leu Leu Thr Lys Cys Gln Ile Trp Ser Ile Val Glu Leu
             260                 265                 270

 gcc cag aac atg ctg cgc tac gct ctg ggc tcg cct tca tct ctt ggt      864
 Ala Gln Asn Met Leu Arg Tyr Ala Leu Gly Ser Pro Ser Ser Leu Gly
         275                 280                 285

 cgt ttc ggg tat agt ttt gtc tct cca ctt cct ctc cga ctt ctc tcc      912
 Arg Phe Gly Tyr Ser Phe Val Ser Pro Leu Pro Leu Arg Leu Leu Ser
     290                 295                 300

 aca gtg gcg gca ggc ctg gga caa ctg cag ctg ctc cta ggc tat gcc      960
 Thr Val Ala Ala Gly Leu Gly Gln Leu Gln Leu Leu Leu Gly Tyr Ala
 305                 310                 315                 320

 agc ctg tgc cag aga cca gct gtg agg gtg tgg gca aag aca gga aaa     1008
 Ser Leu Cys Gln Arg Pro Ala Val Arg Val Trp Ala Lys Thr Gly Lys
                 325                 330                 335

 gca gag gcc agt gga ggg agt ggg gac agg gcc aag gga gct ctt ggg     1056
 Ala Glu Ala Ser Gly Gly Ser Gly Asp Arg Ala Lys Gly Ala Leu Gly
             340                 345                 350

 ctt gat tca caa ggc ctg aat cac tct gta tgt agt acc cca agc tca     1104
 Leu Asp Ser Gln Gly Leu Asn His Ser Val Cys Ser Thr Pro Ser Ser
         355                 360                 365

 ggc cat caa tca ccc cag gag aag gga tcc cga ccc cca cca gga ccc     1152
 Gly His Gln Ser Pro Gln Glu Lys Gly Ser Arg Pro Pro Pro Gly Pro
     370                 375                 380

 agt gag aag cag aca gca cga atg ctg aag gag cac caa ggg gac aga     1200
 Ser Glu Lys Gln Thr Ala Arg Met Leu Lys Glu His Gln Gly Asp Arg
 385                 390                 395                 400

 aac acc cag acc gtg gaa gca cag agc aaa cag ctt cat gtt ctg ggg     1248
 Asn Thr Gln Thr Val Glu Ala Gln Ser Lys Gln Leu His Val Leu Gly
                 405                 410                 415

 gcc tat ctg gag ctt ctg tcc agg gcc tct gtc tgc agc cct caa cct     1296
 Ala Tyr Leu Glu Leu Leu Ser Arg Ala Ser Val Cys Ser Pro Gln Pro
             420                 425                 430

 aca tca gtc ggg cag cag gcg acc cag ctc cgc cac atc cag ccg gtt     1344
 Thr Ser Val Gly Gln Gln Ala Thr Gln Leu Arg His Ile Gln Pro Val
         435                 440                 445

 ggt ggc cat gat gtg ctt cag ctg ctg ccg gta gcg tgc caa gtc ctg     1392
 Gly Gly His Asp Val Leu Gln Leu Leu Pro Val Ala Cys Gln Val Leu
     450                 455                 460

 cat aag gtg ggg cat ccg ggt att atc cag cac ccc atg ggg ccg cag     1440
 His Lys Val Gly His Pro Gly Ile Ile Gln His Pro Met Gly Pro Gln
 465                 470                 475                 480

 gtg gtc cac atc ctc ata gga cac ctt gcc cag tga ggtc agcagcggga     1490
 Val Val His Ile Leu Ile Gly His Leu Ala Gln 
                 485                 490

 aatcgatggt ctggcgatgt cccagaatgc acaggatgcc gttcaggtac acctggtcct   1550

 tgtcccagcg cacgtcggcg tcccgcacgt agcgcgccag gtcctggaag agctggcgga   1610

 aggacagacg cacagcgtgg cggctggtgt agcagagcag agcagcgcag cgcgccacag   1670

 gaacggctgc ttgcggagca gcacgctgtg cagggtggcc aggccctcct cgtggggttc   1730

 gccggccgta gcccgtaccg cagccggccc tccgcgttgt gccacggctg gcgcgcgttg   1790

 ttaccgcccc gcaggtagtg ggtgcaatgg accatatctg gcacttggtg agcagctgcc   1850

 tgccggtggc agcctcaaag tgttcgtagg ttccaaactt ctccagaaca gcctcaatga   1910

 tgccaactgc ctgatggatg aactgtccag aggcctcgca gtacttcagc acagccatag   1970

 gcatgggctc ctggtactcg aactgtggat tgtaggtgta atgcgactga aagaacttgt   2030

 ctccctcacg ggtccacgtt ggttggccgc agggccacca acatgcaggg gctcttgctg   2090

 gcactatggc ctgcatcgct ttgagtctta gtaatgtgag gcagggaggc tgcaggccgc   2150

 agggtgcgcc cacctgggtt ccatcgccgt ccaggtggag gctgtcccag ggtgccacgc   2210

 ccccgccggc cagtactatt tacagagtag gtgctctcac tgcgacgcat gtggccgcgg   2270

 tggcccaggt gcatctgtga gaacgactgc tgctcaggct ggggctgcag tgctgggggg   2330

 actgccagag ccacgggcaa ggccagggac tgagaccagg ggtacagtgg tggcccgtct   2390

 cggtctgagt gcttcagcct atgacgcagg gacagcagac tggtaggtgg gctggtgggt   2450

 gcctgatcat acgcctgaga ccccgagtcc agcaccat                           2488




      <210> 297
      <211> 918
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (128)..(727)

      <400> 297
 cccagcgccc aggaccgtgt ctgggaaaag gtctttgccc ggagagtggg aagagagagg     60

 ggagggtgag cagaggacag gccgggagtt ttccgggaac ggaggaagag cagtggaggc    120

 tgccagg  atg agg ctg ctg tgt ggc ctg tgg ctg tgg ctc tcc ttg ctg     169
          Met Arg Leu Leu Cys Gly Leu Trp Leu Trp Leu Ser Leu Leu
            1               5                  10

 aaa gtc ctg cag gcc cag acc cca acc ccc ctg cca ctc ccg ccc ccg      217
 Lys Val Leu Gln Ala Gln Thr Pro Thr Pro Leu Pro Leu Pro Pro Pro
  15                  20                  25                  30

 atg cag agc ttc caa gga aac cag ttc cag ggg gaa tgg ttc gtc ctg      265
 Met Gln Ser Phe Gln Gly Asn Gln Phe Gln Gly Glu Trp Phe Val Leu
                  35                  40                  45

 ggc ctg gcg ggc aac agc ttc agg ccg gag cac agg gcg ctg ctg aac      313
 Gly Leu Ala Gly Asn Ser Phe Arg Pro Glu His Arg Ala Leu Leu Asn
              50                  55                  60

 gct ttc acc gca act ttt gag cta agt gat gat ggc cgc ttt gag gtg      361
 Ala Phe Thr Ala Thr Phe Glu Leu Ser Asp Asp Gly Arg Phe Glu Val
          65                  70                  75

 tgg aat gcg atg act cga ggc cag cac tgt gac aca tgg tct tat gtg      409
 Trp Asn Ala Met Thr Arg Gly Gln His Cys Asp Thr Trp Ser Tyr Val
      80                  85                  90

 ctg ata ccg gca gcc cag cct ggg cag ttc act gtg gac cac ggt gtg      457
 Leu Ile Pro Ala Ala Gln Pro Gly Gln Phe Thr Val Asp His Gly Val
  95                 100                 105                 110

 gag ccc ggg gcg gac aga gag gag acc cgg gtg gtg gac agc gac tac      505
 Glu Pro Gly Ala Asp Arg Glu Glu Thr Arg Val Val Asp Ser Asp Tyr
                 115                 120                 125

 acc cag ttc gcc ctg atg ctg tcc cgc aga cac acg agc agg ctg gcc      553
 Thr Gln Phe Ala Leu Met Leu Ser Arg Arg His Thr Ser Arg Leu Ala
             130                 135                 140

 gtc ctc agg atc agc ctg ctg ggc agg agc tgg ttg ctg cct ccc ggg      601
 Val Leu Arg Ile Ser Leu Leu Gly Arg Ser Trp Leu Leu Pro Pro Gly
         145                 150                 155

 acg ctg gac cag ttc atc tgc ctg ggc aga gct cag ggc ctc tcg gat      649
 Thr Leu Asp Gln Phe Ile Cys Leu Gly Arg Ala Gln Gly Leu Ser Asp
     160                 165                 170

 gac aac att gtc ttc cca gat gtg act gga ggt gcc ctg gac ctc agc      697
 Asp Asn Ile Val Phe Pro Asp Val Thr Gly Gly Ala Leu Asp Leu Ser
 175                 180                 185                 190

 agc ctg ccc tgg gtg gca gcc cca gct tga c cactcagaca gccgcggccc      748
 Ser Leu Pro Trp Val Ala Ala Pro Ala 
                 195

 ccaaggcctg actcttcttg tgggagggcg aggctggtca ccccaggcca gcgtctgttg    808

 aaggatgaag cagctcctgt ccggcccagc cctgcctcac agctgtgcga gctctgccct    868

 cctcagctct caaacctgaa taaatgcacc aagcccagaa aaaaaaaaaa               918




      <210> 298
      <211> 1019
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (732)..(965)

      <220>
      <221> misc_feature
      <222> (1)...(1019)
      <223> n = a,t,c or g

      <400> 298
 cataaattct attttgtgac tttaatatat agtgaacacc ttttttaatg atgacaggat     60

 gttcccttgc atggctgtat caatttaaac aatcttgttt caatgggcat acagggtatt    120

 ttctagtttt ttttttcctc ttagaaaata atacttgcga tgactttcct tgtagctcag    180

 actttttcac gtctgttgtt atctctttgg gaatgctgaa tacatacatt tcgagaagga    240

 aatgactgtt aaactcttaa gacttcaggt tcatattgct aaactgccca gcagggaggg    300

 attttttcaa ttagtgttct cactggtgag gcaaacctga tgccttcccc tcttcctcag    360

 aaccggcttt atcacattga aaacctttgc tcctccgacg gatcgagtct gctttccctg    420

 tggatgtgag cattgctttg tctgctggtg actgaacatc tctaccatgt gtcaattggc    480

 cnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnttctaa    540

 ttcctagtca tttttctatt gattgttttg caaaagccat ttacatctta aggatattga    600

 taatcttttg ttatatttga tgcaaatatt tttttccagt ttataggttg ccttttaatt    660

 ttgtgtttca ggtagataaa agttaaacga ttttcttagg ttagtttatc actgtggttt    720

 ctgaacttgt t atg tgt aga tct ttt cca ccc caa gag tac ata aat att     770
              Met Cys Arg Ser Phe Pro Pro Gln Glu Tyr Ile Asn Ile
                1               5                  10

 aat cca tac ttt ctt atg gaa ctt gta tgg ttt cgt ttt tta cat tta      818
 Asn Pro Tyr Phe Leu Met Glu Leu Val Trp Phe Arg Phe Leu His Leu
      15                  20                  25

 aac ctt ctt ccc cgt ggt gtg tgt tgt gga atc tgt gtt tgt gtg agg      866
 Asn Leu Leu Pro Arg Gly Val Cys Cys Gly Ile Cys Val Cys Val Arg
  30                  35                  40                  45

 agg ggc atg gtg ctc tca gaa ccc acc tcc tgt ggc cag aga gcc ctg      914
 Arg Gly Met Val Leu Ser Glu Pro Thr Ser Cys Gly Gln Arg Ala Leu
                  50                  55                  60

 tcc tgt gag ggt ggt tat cac agt ggc agg gtt caa ttc aga aga cct      962
 Ser Cys Glu Gly Gly Tyr His Ser Gly Arg Val Gln Phe Arg Arg Pro
              65                  70                  75

 tga gggc aggctgatgt ttcctgaatg ggcccctggt tgttgcttgt ccctgactct     1019
 






      <210> 299
      <211> 392
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (1)..(345)

      <400> 299
  atg atg agg ttg tcc cta gtt gtt ctc aaa gtt gct gtt acc ttg aaa      48
  Met Met Arg Leu Ser Leu Val Val Leu Lys Val Ala Val Thr Leu Lys
    1               5                  10                  15

 aat gac ttc cct ggg aac cag aac atc cag gtt ggc ctc aaa ctt gct       96
 Asn Asp Phe Pro Gly Asn Gln Asn Ile Gln Val Gly Leu Lys Leu Ala
              20                  25                  30

 gcc aaa cag gaa ctg tgg caa gcc gga gag gat tct gat gct tgg aac      144
 Ala Lys Gln Glu Leu Trp Gln Ala Gly Glu Asp Ser Asp Ala Trp Asn
          35                  40                  45

 ttc ttg tcc tat cgg cca acc ccc gac ctg aag gcc agt gtc aaa gtg      192
 Phe Leu Ser Tyr Arg Pro Thr Pro Asp Leu Lys Ala Ser Val Lys Val
      50                  55                  60

 tca ggg tgt caa agt gca gaa ttg tca ggc aag atg atg atg aat gaa      240
 Ser Gly Cys Gln Ser Ala Glu Leu Ser Gly Lys Met Met Met Asn Glu
  65                  70                  75                  80

 gtc ctg gca gct tcc tgt gtc cca ggc ctt gta gaa ata aat gag aca      288
 Val Leu Ala Ala Ser Cys Val Pro Gly Leu Val Glu Ile Asn Glu Thr
                  85                  90                  95

 gac gtg ctt caa agt tct aat gtg cat cac atc gga tct tgt tta agg      336
 Asp Val Leu Gln Ser Ser Asn Val His His Ile Gly Ser Cys Leu Arg
             100                 105                 110

 aag cgt taa aaggaac ccgccgttac ctattgagaa ggctctgtac tctcaggcat      392
 Lys Arg 






      <210> 300
      <211> 562
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (191)..(532)

      <400> 300
 ctgtgtagag gtgtggactc agtttattct agcaggccaa acctccgaga ctatccttaa     60

 acatcagtag actgtgaggg gtacgtggac gggagtagct tcgccaaccc ctgcaaagtg    120

 actctgaaga agacgacaag ctctgctcca gtcacaccca gaagctgact ggtccacgca    180

 cggccgaagc   atg aga aaa ctc att gcg gaa ctc att ttc ctt aaa att     229
              Met Arg Lys Leu Ile Ala Glu Leu Ile Phe Leu Lys Ile
                1               5                  10

 tgg act ttt aca gta agg act tca act gac ctt cct cag act gag gac      277
 Trp Thr Phe Thr Val Arg Thr Ser Thr Asp Leu Pro Gln Thr Glu Asp
      15                  20                  25

 tgt tcc cag tat ata cat caa gtc act gag gta gga caa aag gtt gct      325
 Cys Ser Gln Tyr Ile His Gln Val Thr Glu Val Gly Gln Lys Val Ala
  30                  35                  40                  45

 atg gtc cta tta ttt tac agt tat cat aag tgt act aga act cta aaa      373
 Met Val Leu Leu Phe Tyr Ser Tyr His Lys Cys Thr Arg Thr Leu Lys
                  50                  55                  60

 aag cct tgt ttg tat aat gtt att ctg tac aag gta tgt agc cca gga      421
 Lys Pro Cys Leu Tyr Asn Val Ile Leu Tyr Lys Val Cys Ser Pro Gly
              65                  70                  75

 aat gac caa cct gat gtg cgt tat gac cca cct gag cct ccc atg atc      469
 Asn Asp Gln Pro Asp Val Arg Tyr Asp Pro Pro Glu Pro Pro Met Ile
          80                  85                  90

 aca gtt ttt aaa ata aga tta aga cac tgc aga ctg gtg ggg gct cac      517
 Thr Val Phe Lys Ile Arg Leu Arg His Cys Arg Leu Val Gly Ala His
      95                 100                 105

 aaa cga tat gag taa agtgttaacc acaacagtaa gaaaaagcaa                 562
 Lys Arg Tyr Glu 
 110





      <210> 301
      <211> 1677
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (205)..(1677)

      <400> 301
 ccagacacag ccttgcccca gttactgccc acctgcaaga gatccacatt tctgtcctcc     60

 agagctccca aactgatggg ggagagagac atcatccccc agctctggga gtttccagtc    120

 tgatggagga gacagagcct gcttcggtaa ctctcactct gcgggggaag actcagccct    180

 atccagggag ctcccacact ttca   atg ggg agg ccc acc cag tgg ccg agc     231
                              Met Gly Arg Pro Thr Gln Trp Pro Ser
                                1               5

 ctg ctg ctg ctc ctg ctg ttg ccg ggg ccc ccg ccc gtc gcc ggc ttg      279
 Leu Leu Leu Leu Leu Leu Leu Pro Gly Pro Pro Pro Val Ala Gly Leu
  10                  15                  20                  25

 gaa gac gct gcc ttc ccc cac ctg ggg gag agc ttg cag ccc ctg ccc      327
 Glu Asp Ala Ala Phe Pro His Leu Gly Glu Ser Leu Gln Pro Leu Pro
                  30                  35                  40

 cgg gcc tgt ccc ctg cgc tgc tcc tgc ccc cga gtc gac act gtg gac      375
 Arg Ala Cys Pro Leu Arg Cys Ser Cys Pro Arg Val Asp Thr Val Asp
              45                  50                  55

 tgt gat ggc ttg gac ctt cga gtg ttc ccg gac aac atc acc aga gcc      423
 Cys Asp Gly Leu Asp Leu Arg Val Phe Pro Asp Asn Ile Thr Arg Ala
          60                  65                  70

 gct cag cac ctc tcc ctg cag aac aac cag ctc cag gaa ctc ccc tac      471
 Ala Gln His Leu Ser Leu Gln Asn Asn Gln Leu Gln Glu Leu Pro Tyr
      75                  80                  85

 aat gag ctg tcc cgc ctc agt ggc ctg cga acc ctc aac ctc cac aac      519
 Asn Glu Leu Ser Arg Leu Ser Gly Leu Arg Thr Leu Asn Leu His Asn
  90                  95                 100                 105

 aac ctc atc tcc tcc gaa ggc ctg cct gac gag gcc ttc gag tcc ctc      567
 Asn Leu Ile Ser Ser Glu Gly Leu Pro Asp Glu Ala Phe Glu Ser Leu
                 110                 115                 120

 acc cag ctg cag cac ctc tgc gtg gct cac aac aag aac aat ctc atc      615
 Thr Gln Leu Gln His Leu Cys Val Ala His Asn Lys Asn Asn Leu Ile
             125                 130                 135

 tcc aag gtg ccc cga gga gcc ctg agc cgc cag act caa ctc cgt gag      663
 Ser Lys Val Pro Arg Gly Ala Leu Ser Arg Gln Thr Gln Leu Arg Glu
         140                 145                 150

 ctc tac ctc cag cac aac cag ctg aca gac agt ggc ctg gat gcc acc      711
 Leu Tyr Leu Gln His Asn Gln Leu Thr Asp Ser Gly Leu Asp Ala Thr
     155                 160                 165

 acc ttc agc aag ctg cat agc ctt gaa tac ctg gat ctc tcc cac aac      759
 Thr Phe Ser Lys Leu His Ser Leu Glu Tyr Leu Asp Leu Ser His Asn
 170                 175                 180                 185

 cag ctg acc aca gtg ccc gcc ggc ctg ccc cgg acc ctg gct atc ctg      807
 Gln Leu Thr Thr Val Pro Ala Gly Leu Pro Arg Thr Leu Ala Ile Leu
                 190                 195                 200

 cac ctg ggc cgc aac cgc atc cgg cag gtg gag gcg gct cgg ctg cac      855
 His Leu Gly Arg Asn Arg Ile Arg Gln Val Glu Ala Ala Arg Leu His
             205                 210                 215

 ggg gcg cgt ggt ctg cgc tat ttg ttg ctg cag cac aac cag ctg ggg      903
 Gly Ala Arg Gly Leu Arg Tyr Leu Leu Leu Gln His Asn Gln Leu Gly
         220                 225                 230

 agc tca ggg ctg ccc gcc ggg gct ctg cgg ccg ctg cgg ggc ctg cac      951
 Ser Ser Gly Leu Pro Ala Gly Ala Leu Arg Pro Leu Arg Gly Leu His
     235                 240                 245

 acg ctg cac ctc tat ggc aat ggg ctg gac cgc gtg cct cca gcc ctg      999
 Thr Leu His Leu Tyr Gly Asn Gly Leu Asp Arg Val Pro Pro Ala Leu
 250                 255                 260                 265

 ccc cgc cgc ctg cgt gcc ctg gtg ctg ccc cac aac cac gtg gcc gcg     1047
 Pro Arg Arg Leu Arg Ala Leu Val Leu Pro His Asn His Val Ala Ala
                 270                 275                 280

 ctg ggt gcc cgt gac ctg gtc gcc aca ccg ggc ctg acg gag ctt aac     1095
 Leu Gly Ala Arg Asp Leu Val Ala Thr Pro Gly Leu Thr Glu Leu Asn
             285                 290                 295

 ctg gcc tat aac cgc ctg gcc agc gcc cgt gtg cac cac cgg gcc ttc     1143
 Leu Ala Tyr Asn Arg Leu Ala Ser Ala Arg Val His His Arg Ala Phe
         300                 305                 310

 cgc cgg ttg cgt gcc ctg cgc agc ctc gac ctg gca ggg aat cag cta     1191
 Arg Arg Leu Arg Ala Leu Arg Ser Leu Asp Leu Ala Gly Asn Gln Leu
     315                 320                 325

 acc cgg ctg ccc atg ggc ctg ccc act ggc ctg cgc acc ctg cag ctg     1239
 Thr Arg Leu Pro Met Gly Leu Pro Thr Gly Leu Arg Thr Leu Gln Leu
 330                 335                 340                 345

 caa cgc aac cag ctg cgg atg ctc gag ccc gag cct ctg gcc ggc ctg     1287
 Gln Arg Asn Gln Leu Arg Met Leu Glu Pro Glu Pro Leu Ala Gly Leu
                 350                 355                 360

 gac caa ctg cgg gag ctc agc ctg gcg cac aac cgg ctc cgg gtc ggc     1335
 Asp Gln Leu Arg Glu Leu Ser Leu Ala His Asn Arg Leu Arg Val Gly
             365                 370                 375

 gac atc ggg cca ggc acc tgg cat gag ctc caa gcc ctc cag atg ctg     1383
 Asp Ile Gly Pro Gly Thr Trp His Glu Leu Gln Ala Leu Gln Met Leu
         380                 385                 390

 gac ctc agc cac aat gag ctg tcc ttt gtg ccc ccg gac ctg cct gag     1431
 Asp Leu Ser His Asn Glu Leu Ser Phe Val Pro Pro Asp Leu Pro Glu
     395                 400                 405

 gcc cta gag gag ctg cac ctc gag ggc aac cgc atc ggc cac gtg ggc     1479
 Ala Leu Glu Glu Leu His Leu Glu Gly Asn Arg Ile Gly His Val Gly
 410                 415                 420                 425

 ccc gag gcc ttc ctc agc aca ccc cgc ctg cgt gcc ctc ttc ctc agg     1527
 Pro Glu Ala Phe Leu Ser Thr Pro Arg Leu Arg Ala Leu Phe Leu Arg
                 430                 435                 440

 gcc aac agg ctt cac atg acg agc atc gcg gct gag gcc ttc ctg ggg     1575
 Ala Asn Arg Leu His Met Thr Ser Ile Ala Ala Glu Ala Phe Leu Gly
             445                 450                 455

 ctc cca aac ctg cgt gtg gtg gac acg gca ggg aat ccg gag cag gtc     1623
 Leu Pro Asn Leu Arg Val Val Asp Thr Ala Gly Asn Pro Glu Gln Val
         460                 465                 470

 ctg atc cgg ctg cct ccc acc acc cca cgt ggg cca cgg gca ggg ggc     1671
 Leu Ile Arg Leu Pro Pro Thr Thr Pro Arg Gly Pro Arg Ala Gly Gly
     475                 480                 485

 ccc tga                                                             1677
 Pro 
 490





      <210> 302
      <211> 875
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (12)..(875)

      <400> 302
 ggtgtggcag a atg aag cct ctg ctt gaa acc ctt tat ctt ttg ggg atg      50
              Met Lys Pro Leu Leu Glu Thr Leu Tyr Leu Leu Gly Met
                1               5                  10

 ctg gtt cct gga ggg ctg gga tat gat aga tcc tta gcc caa cac aga       98
 Leu Val Pro Gly Gly Leu Gly Tyr Asp Arg Ser Leu Ala Gln His Arg
      15                  20                  25

 caa gag att gtg gac aag tca gtg agt cca tgg agc ctg gag acg tat      146
 Gln Glu Ile Val Asp Lys Ser Val Ser Pro Trp Ser Leu Glu Thr Tyr
  30                  35                  40                  45

 tcc tat aac ata tac cac ccc atg gga gag atc tat gag tgg atg aga      194
 Ser Tyr Asn Ile Tyr His Pro Met Gly Glu Ile Tyr Glu Trp Met Arg
                  50                  55                  60

 gag atc agt gag aag tac aag gaa gtg gtg aca cag cat ttc cta gga      242
 Glu Ile Ser Glu Lys Tyr Lys Glu Val Val Thr Gln His Phe Leu Gly
              65                  70                  75

 gtg acc tat gag acc cac ccc ata tat tat ctg aag atc agc caa cca      290
 Val Thr Tyr Glu Thr His Pro Ile Tyr Tyr Leu Lys Ile Ser Gln Pro
          80                  85                  90

 tct ggt aat ccc aag aaa atc att tgg atg gac tgt gga att cac gcc      338
 Ser Gly Asn Pro Lys Lys Ile Ile Trp Met Asp Cys Gly Ile His Ala
      95                 100                 105

 aga gaa tgg att gct cct gct ttt tgc caa tgg ttc gtc aaa gaa att      386
 Arg Glu Trp Ile Ala Pro Ala Phe Cys Gln Trp Phe Val Lys Glu Ile
 110                 115                 120                 125

 cta caa aac cat aaa gac aac tca agg ata cgc aag ctc ctt agg aac      434
 Leu Gln Asn His Lys Asp Asn Ser Arg Ile Arg Lys Leu Leu Arg Asn
                 130                 135                 140

 ctg gac ttc tat gtc ctt cca gtt ctt aac ata gat ggt tat atc tac      482
 Leu Asp Phe Tyr Val Leu Pro Val Leu Asn Ile Asp Gly Tyr Ile Tyr
             145                 150                 155

 act tgg aca act gat cgt ctt tgg agg aaa tcc cgt tca ccc cat aat      530
 Thr Trp Thr Thr Asp Arg Leu Trp Arg Lys Ser Arg Ser Pro His Asn
         160                 165                 170

 aat ggc aca tgt ttt ggg acg gat ctc aat cga aat ttc aat gct tct      578
 Asn Gly Thr Cys Phe Gly Thr Asp Leu Asn Arg Asn Phe Asn Ala Ser
     175                 180                 185

 tgg tgt agt att ggt gcc tct aga aac tgc caa gat caa aca ttc tgt      626
 Trp Cys Ser Ile Gly Ala Ser Arg Asn Cys Gln Asp Gln Thr Phe Cys
 190                 195                 200                 205

 ggg aca ggg cca gtg tct gaa cca gag act aaa gct gtt gcc agc ttc      674
 Gly Thr Gly Pro Val Ser Glu Pro Glu Thr Lys Ala Val Ala Ser Phe
                 210                 215                 220

 ata gag agc aag aag gat gat att ttg tgc ttc ctg acc atg cac tct      722
 Ile Glu Ser Lys Lys Asp Asp Ile Leu Cys Phe Leu Thr Met His Ser
             225                 230                 235

 tat ggg cag tta att ctc aca cct tac ggc tac acc aaa aat aaa tca      770
 Tyr Gly Gln Leu Ile Leu Thr Pro Tyr Gly Tyr Thr Lys Asn Lys Ser
         240                 245                 250

 agt aac cac cca gaa atg att caa gtt gga cag aag gca gca tat gca      818
 Ser Asn His Pro Glu Met Ile Gln Val Gly Gln Lys Ala Ala Tyr Ala
     255                 260                 265

 ttg aaa gca aag tat gga acc aat tat agg agt gga tcg agt gca gat      866
 Leu Lys Ala Lys Tyr Gly Thr Asn Tyr Arg Ser Gly Ser Ser Ala Asp
 270                 275                 280                 285

 att tta tag                                                          875
 Ile Leu 






      <210> 303
      <211> 437
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (54)..(398)

      <400> 303
 tccagttggt gaccaagagt acatctcttt tcaaatagct ggattaggtc ctc   atg      56
                                                              Met
                                                                1

 ctg ctg tgg tca ttg ctg gtc atc ttt gat gca gtc act gaa cag gca      104
 Leu Leu Trp Ser Leu Leu Val Ile Phe Asp Ala Val Thr Glu Gln Ala
               5                  10                  15

 gat tcg ctg acc ctt gtg gcg ccc tct tct gtc ttc gaa gga gac agc      152
 Asp Ser Leu Thr Leu Val Ala Pro Ser Ser Val Phe Glu Gly Asp Ser
          20                  25                  30

 atc gtt ctg aaa tgc cag gga gaa cag aac tgg aaa att cag aag atg      200
 Ile Val Leu Lys Cys Gln Gly Glu Gln Asn Trp Lys Ile Gln Lys Met
      35                  40                  45

 gct tac cat aag gat aac aag gag tta tct gtt ttc aaa aaa ttc tca      248
 Ala Tyr His Lys Asp Asn Lys Glu Leu Ser Val Phe Lys Lys Phe Ser
  50                  55                  60                  65

 gat ttc ctt atc caa agt gca gtt tta agt gac agt ggt aac tat ttc      296
 Asp Phe Leu Ile Gln Ser Ala Val Leu Ser Asp Ser Gly Asn Tyr Phe
                  70                  75                  80

 tgt agt acc aaa gga caa ctc ttt ctc tgg gat aaa act tca aat ata      344
 Cys Ser Thr Lys Gly Gln Leu Phe Leu Trp Asp Lys Thr Ser Asn Ile
              85                  90                  95

 gta aag ata aaa gtc caa ggt aaa acc ctg act tct gtg gga tgg gct      392
 Val Lys Ile Lys Val Gln Gly Lys Thr Leu Thr Ser Val Gly Trp Ala
         100                 105                 110

 ggg tga gagaccacgg cagcaaggca gggtgggtac tgcgtaacg                   437
 Gly 






      <210> 304
      <211> 1697
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (59)..(667)

      <400> 304
 ccgaggctga gcggtccctt ctcgctgcgg ccgcccaggt gcccgcgccc gtggcgct       58                                                                 
 atg gag gcg gcg ctg ctg ggg ctg tgt aac tgg agc acg ctg ggc gtg      106
 Met Glu Ala Ala Leu Leu Gly Leu Cys Asn Trp Ser Thr Leu Gly Val
   1               5                  10                  15

 tgc gcc gcg ctg aag ctg ccg cag atc tcc gct gtg cta gcg gcg cgc      154
 Cys Ala Ala Leu Lys Leu Pro Gln Ile Ser Ala Val Leu Ala Ala Arg
              20                  25                  30

 agc gcg cgg ggc ctc agc ctt ccg agt tta ctt ctg gag ctg gca gga      202
 Ser Ala Arg Gly Leu Ser Leu Pro Ser Leu Leu Leu Glu Leu Ala Gly
          35                  40                  45

 ttc ctg gtg ttt ctg cgg tac cag tgt tac tat ggg tat ccg ccg ctg      250
 Phe Leu Val Phe Leu Arg Tyr Gln Cys Tyr Tyr Gly Tyr Pro Pro Leu
      50                  55                  60

 acc tac ctg gag tac ccc atc ctc atc gcg caa gat gtc atc ctc ctg      298
 Thr Tyr Leu Glu Tyr Pro Ile Leu Ile Ala Gln Asp Val Ile Leu Leu
  65                  70                  75                  80

 ctc tgt atc ttt cat ttt aac ggg aac gtg aag cag gcc act cct tac      346
 Leu Cys Ile Phe His Phe Asn Gly Asn Val Lys Gln Ala Thr Pro Tyr
                  85                  90                  95

 atc gct gta ttg gtg tct tct tgg ttc atc ctt gcc ctg cag aag tgg      394
 Ile Ala Val Leu Val Ser Ser Trp Phe Ile Leu Ala Leu Gln Lys Trp
             100                 105                 110

 atc ata gac ctg gcc atg aat cta tgt act ttc atc agc gcg gcc agt      442
 Ile Ile Asp Leu Ala Met Asn Leu Cys Thr Phe Ile Ser Ala Ala Ser
         115                 120                 125

 aag ttt gca cag ctc cag tgt ctg tgg aag acg aga gac tca gga act      490
 Lys Phe Ala Gln Leu Gln Cys Leu Trp Lys Thr Arg Asp Ser Gly Thr
     130                 135                 140

 gtg agt gcg ctg act tgg agc ctc tct tcc tat acc tgt gca aca aga      538
 Val Ser Ala Leu Thr Trp Ser Leu Ser Ser Tyr Thr Cys Ala Thr Arg
 145                 150                 155                 160

 ata atc aca acc tta atg acc acc aat gat ttt aca att ctt cta cgt      586
 Ile Ile Thr Thr Leu Met Thr Thr Asn Asp Phe Thr Ile Leu Leu Arg
                 165                 170                 175

 ttt gtg atc atg ctg gct tta aat ata tgg gta aca gtg aca gta ctt      634
 Phe Val Ile Met Leu Ala Leu Asn Ile Trp Val Thr Val Thr Val Leu
             180                 185                 190

 cgc tac cgg aag acc gct ata aag gct gaa tga tggataca ttattccttc      685
 Arg Tyr Arg Lys Thr Ala Ile Lys Ala Glu 
         195                 200

 acacagtgga ttttgagtaa ctgaaccaaa ggaaaaagaa gctctttgct aaattaaggt    745

 cttttataaa tttagtaaat cagtttataa tctttaaagc caaaggtttt tttagacttg    805

 aaagaaagag ccacttaaat tcttgtttaa aaataccaat ttgcctcctc cttcctcact    865

 tcgttaggtt atggtagtgc tcagacatct gcagtgttga gaaggccagt cactgttgga    925

 agtcatccaa gaagcccatt ttgagcctta ctcttaagtt ctctatgaag aactacattg    985

 atttgttggc tttcagaatc ttttaggaaa taaatcctct ccaggacaaa aatgaacatg   1045

 aatggagtgg cattttgttc caagtcagag gtgggcacct ataataaatg actagggttc   1105

 actttctggg actgatgttt aattgtaaca cagatacaac agggtggcct tgttgtgtat   1165

 aatacggtat tatacctgca tgtgctctag caaggatacc aaggcaagca tacatgtagc   1225

 tggcttgagt ttgtaccaaa acagtccttc aactttgcac tgtgccttaa gtaattacta   1285

 acaaaaggta ctaggattag ctgcaatctc tactttcgat gaggaaatcc cagtaagctt   1345

 tctgattcaa gtacaatgct gccatttttt aaagggccac aactatagaa ttaccactgt   1405

 tggaatttgg tacaaaatat gttttgtcta ttgaaaacat acacggtaaa tggtgttgtt   1465

 aggtaggttc tgtccagttc ttagggactt ttttcacatt atagcatttt taccctaaac   1525

 atgatgttga gattattata tactgtattt tcttctaaat taaccctaat gtttaaaaac   1585

 tcactttccc cctttaattg aaggcattgt tttgttagat gcagtaatga tgtttaccag   1645

 agattattgt ttcctatgca aaataaattt tcatattttg aaaaaaaaaa aa           1697




      <210> 305
      <211> 624
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (27)..(590)

      <400> 305
 aggctttaat taaggaggtt aacacc atg ggg cct gga cga tgc ctc ctg acg      53
                              Met Gly Pro Gly Arg Cys Leu Leu Thr
                                1               5

 gcc ttg ttg ctt ctg gcc ctg gcg cca ccg ccg gaa gcc tcc cag tac      101
 Ala Leu Leu Leu Leu Ala Leu Ala Pro Pro Pro Glu Ala Ser Gln Tyr
  10                  15                  20                  25

 tgc ggc cgc ctt gaa tac tgg aac cca gac aac aag tgc tgc agc agc      149
 Cys Gly Arg Leu Glu Tyr Trp Asn Pro Asp Asn Lys Cys Cys Ser Ser
                  30                  35                  40

 tgc ctg caa cgc ttc ggg ccg ccc ccc tgc ccg ggc gcc ctg gag aca      197
 Cys Leu Gln Arg Phe Gly Pro Pro Pro Cys Pro Gly Ala Leu Glu Thr
              45                  50                  55

 ggg gac aca tgg aag gag gcc tca cta ctt cca ctc ctg agc agg gaa      245
 Gly Asp Thr Trp Lys Glu Ala Ser Leu Leu Pro Leu Leu Ser Arg Glu
          60                  65                  70

 ctg tcc agt ctg gcg tca caa ccc ctg tct cgc ctc ctg gat gag ctg      293
 Leu Ser Ser Leu Ala Ser Gln Pro Leu Ser Arg Leu Leu Asp Glu Leu
      75                  80                  85

 gag gtg ctg gaa gag ctg att gta ctg ctg gac cct gag cct ggg cca      341
 Glu Val Leu Glu Glu Leu Ile Val Leu Leu Asp Pro Glu Pro Gly Pro
  90                  95                 100                 105

 ggt ggg ggt atg gcc cat ggc act act cga cac ctg gcc gca aga tat      389
 Gly Gly Gly Met Ala His Gly Thr Thr Arg His Leu Ala Ala Arg Tyr
                 110                 115                 120

 ggg ctg cct gct gcc tgg tcc acc ttt gcc tat tcg ctg agg ccg agt      437
 Gly Leu Pro Ala Ala Trp Ser Thr Phe Ala Tyr Ser Leu Arg Pro Ser
             125                 130                 135

 cgc tcg ccg ctg cgg gct ctg att gag atg gtg gtg gca agg gag ccc      485
 Arg Ser Pro Leu Arg Ala Leu Ile Glu Met Val Val Ala Arg Glu Pro
         140                 145                 150

 tct gcc tcc ctg ggc cag ctt ggc aca cac ctc gcc cac cta ggg cgg      533
 Ser Ala Ser Leu Gly Gln Leu Gly Thr His Leu Ala His Leu Gly Arg
     155                 160                 165

 gca gat gca ttg cgg gtg ctg tcc aag ctt ggc tca tct ggg gtt tgc      581
 Ala Asp Ala Leu Arg Val Leu Ser Lys Leu Gly Ser Ser Gly Val Cys
 170                 175                 180                 185

 tgg gct taa cacccaaacc gaggtacctg ctagcgggct tacc                    624
 Trp Ala 






      <210> 306
      <211> 564
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (27)..(530)

      <400> 306
 aggctttaat taaggaggtt aacacc atg ggg cct gga cga tgc ctc ctg acg      53
                              Met Gly Pro Gly Arg Cys Leu Leu Thr
                                1               5

 gcc ttg ttg ctt ctg gcc ctg gcg cca ccg ccg gaa gcc tcc cag tac      101
 Ala Leu Leu Leu Leu Ala Leu Ala Pro Pro Pro Glu Ala Ser Gln Tyr
  10                  15                  20                  25

 tgc ggc cgc ctt gaa tac tgg aac cca gac aac aag tgc tgc agc agc      149
 Cys Gly Arg Leu Glu Tyr Trp Asn Pro Asp Asn Lys Cys Cys Ser Ser
                  30                  35                  40

 tgc ctg caa cgc ttc ggg ccg ccc ccc tgc ccg gac ctg ctg aat acg      197
 Cys Leu Gln Arg Phe Gly Pro Pro Pro Cys Pro Asp Leu Leu Asn Thr
              45                  50                  55

 gcg tac cca cgg ctg gat ggc ctc ctg gat gag ctg gag gtg ctg gaa      245
 Ala Tyr Pro Arg Leu Asp Gly Leu Leu Asp Glu Leu Glu Val Leu Glu
          60                  65                  70

 gag ctg att gta ctg ctg gac cct gag cct ggg cca ggt ggg ggt atg      293
 Glu Leu Ile Val Leu Leu Asp Pro Glu Pro Gly Pro Gly Gly Gly Met
      75                  80                  85

 gcc cat ggc act act cga cac ctg gcc gca aga tat ggg ctg cct gct      341
 Ala His Gly Thr Thr Arg His Leu Ala Ala Arg Tyr Gly Leu Pro Ala
  90                  95                 100                 105

 gcc tgg tcc acc ttt gcc tat tcg ctg agg ccg agt cgc tcg ccg ctg      389
 Ala Trp Ser Thr Phe Ala Tyr Ser Leu Arg Pro Ser Arg Ser Pro Leu
                 110                 115                 120

 cgg gct ctg att gag atg gtg gtg gca agg gag ccc tct gcc tcc ctg      437
 Arg Ala Leu Ile Glu Met Val Val Ala Arg Glu Pro Ser Ala Ser Leu
             125                 130                 135

 ggc cag ctt ggc aca cac ctc gcc cag cta ggg cgg gca gat gca ttg      485
 Gly Gln Leu Gly Thr His Leu Ala Gln Leu Gly Arg Ala Asp Ala Leu
         140                 145                 150

 cgg gtg ctg tcc aag ctt ggc tca tct ggg gtt tgc tgg gct taa cac      533
 Arg Val Leu Ser Lys Leu Gly Ser Ser Gly Val Cys Trp Ala 
     155                 160                 165

 ccaaaccgag gtacctgcta gcgggcttac c                                   564




      <210> 307
      <211> 548
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (67)..(414)

      <400> 307
 ccgctctagg tttggtactc tgcccccaga ggatgaaggc aagagagatg aaggtgtgcc     60

 attgac   atg ctc ggg ggc ctg gtg ggg aca atc acc cta ggc ctg cct     108
          Met Leu Gly Gly Leu Val Gly Thr Ile Thr Leu Gly Leu Pro
            1               5                  10

 ctt tcc att gag ggc tgg gca cag tca cca tca ggg aga gca ggg gag      156
 Leu Ser Ile Glu Gly Trp Ala Gln Ser Pro Ser Gly Arg Ala Gly Glu
  15                  20                  25                  30

 ggg ggc ttc agt cac cag gct ccc cat ata cat gcc agg ccc cag gtg      204
 Gly Gly Phe Ser His Gln Ala Pro His Ile His Ala Arg Pro Gln Val
                  35                  40                  45

 acc cca ccc tgt tgt cta ggc agc ctg gcc ctg aga cag cct tgt gct      252
 Thr Pro Pro Cys Cys Leu Gly Ser Leu Ala Leu Arg Gln Pro Cys Ala
              50                  55                  60

 gag gcc ctg gag tgg gac gtt cca ctg ggc gag ggg gac atg ggt gcc      300
 Glu Ala Leu Glu Trp Asp Val Pro Leu Gly Glu Gly Asp Met Gly Ala
          65                  70                  75

 agg ccc tgt gct aga cgg ttt ccc ctg gct cct acc acc ggg cgc aaa      348
 Arg Pro Cys Ala Arg Arg Phe Pro Leu Ala Pro Thr Thr Gly Arg Lys
      80                  85                  90

 gcg ggc tgg gga ttg agg cta aga ggc agc ctg cat gaa tgt ggg agg      396
 Ala Gly Trp Gly Leu Arg Leu Arg Gly Ser Leu His Glu Cys Gly Arg
  95                 100                 105                 110

 gac tgg cca ggc cct tga tgctct gccctggagc cctggccacc ccaggacctc      450
 Asp Trp Pro Gly Pro 
                 115

 cagctgccag tgagttctct gccccacccc tgcccatcca gcacttctcc tgtggtctga    510

 cagtagactc ctggttagtg cgttttttcc cagctccc                            548




      <210> 308
      <211> 498
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (302)..(448)

      <400> 308
 cgccgcgttg tgtagacgac actgttagcg ttctctatta gtaggaatcc agggctcctg     60

 acgagctgta tgaatagtcc aaaaatgagc aaaggggttc catggcgtgt gccgcctata    120

 caacactcaa acatgtaata gggaaggttt ccgttcagta gaaaggtggg cgctgtgatt    180

 ttccgcaggg tttcggacga tttgaatcac cggcactaga gtcaggttcc gtctcaaaac    240

 aaaaataaat aaaataaaat atgctaattc taaaattatt ttaaagaata ggttcatatc    300

 t    atg agc agg atg ata ctg ttt aca gta ctg ttt aga gta tgt ata     346
      Met Ser Arg Met Ile Leu Phe Thr Val Leu Phe Arg Val Cys Ile
        1               5                  10                  15

 gaa tct gac att tta tac atg ctt gtt aca tgt ata atg aca aac agt      394
 Glu Ser Asp Ile Leu Tyr Met Leu Val Thr Cys Ile Met Thr Asn Ser
                  20                  25                  30

 ttg agt tgt cct cca ggt agt tca ttt tct tac ttt ttg ttt ctt cta      442
 Leu Ser Cys Pro Pro Gly Ser Ser Phe Ser Tyr Phe Leu Phe Leu Leu
              35                  40                  45

 agt tag aacatcctaa ctcatatgta gagctcgttt ggtgcctctg tcagatacat       498
 Ser 






      <210> 309
      <211> 628
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (233)..(376)

      <400> 309
 ctaaattaga taagttttat ttgcttattt tatttgcttt taacacattt tgaagttatg     60

 tgtgaggtaa tttccattgt tctagtttta attcaaacaa tactgaacat acttacaata    120

 tctaaagatc tttggccttt ctttgcagaa ttaattggaa aaggtacaat aaatatgcaa    180

 tatgtcactc accattttaa tattctaaat ttagcaattg ctcttatatc ta    atg     235
                                                              Met
                                                                1

 att aat aat ata agt tgt tct agt ttc ctt tat ctg ctg tgg tat aaa      283
 Ile Asn Asn Ile Ser Cys Ser Ser Phe Leu Tyr Leu Leu Trp Tyr Lys
               5                  10                  15

 ttt ggc tgc tca tcc aat aat aaa act att tat att ttt aac att ttc      331
 Phe Gly Cys Ser Ser Asn Asn Lys Thr Ile Tyr Ile Phe Asn Ile Phe
          20                  25                  30

 aaa tat cat tac tac tgc tat tta cta gtc tca gtg aca atc tga gat      379
 Lys Tyr His Tyr Tyr Cys Tyr Leu Leu Val Ser Val Thr Ile 
      35                  40                  45

 tctccctaga tgcttaaagg accctttttc aggggcaaaa ataaaaaatt ccaacgaata    439

 aaatcttaaa tggtcacaac gaccacgccc cttttaacat aataaataaa tgattagcct    499

 ctgtattact aacagaaaac tccgtacttt aaagctcata ccttgcaaga tgttataatg    559

 ccggaagcct gtactccacc catagagccg ggtttaggga atcttttaaa aatacaaaat    619

 tgaatgcag                                                            628




      <210> 310
      <211> 825
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (1)..(825)

      <400> 310
  atg ttt gtc ttg ctc tat gtt aca agt ttt gcc att tgt gcc agt gga      48
  Met Phe Val Leu Leu Tyr Val Thr Ser Phe Ala Ile Cys Ala Ser Gly
    1               5                  10                  15

 caa ccc cgg ggt aat cag ttg aaa gga gag aac tac tcc ccc agg tat       96
 Gln Pro Arg Gly Asn Gln Leu Lys Gly Glu Asn Tyr Ser Pro Arg Tyr
              20                  25                  30

 atc tgc agc att cct ggc ttg cct gga cct cca ggg ccc cct gga gca      144
 Ile Cys Ser Ile Pro Gly Leu Pro Gly Pro Pro Gly Pro Pro Gly Ala
          35                  40                  45

 aat ggt tcc cct ggg ccc cat ggt cgc atc ggc ctt cca gga aga gat      192
 Asn Gly Ser Pro Gly Pro His Gly Arg Ile Gly Leu Pro Gly Arg Asp
      50                  55                  60

 ggt aga gac ggc agg aaa gga gag aaa ggt gaa aag gga act gca ggt      240
 Gly Arg Asp Gly Arg Lys Gly Glu Lys Gly Glu Lys Gly Thr Ala Gly
  65                  70                  75                  80

 ttg aga ggt aag act gga ccg cta ggt ctt gcc ggt gag aaa ggg gac      288
 Leu Arg Gly Lys Thr Gly Pro Leu Gly Leu Ala Gly Glu Lys Gly Asp
                  85                  90                  95

 caa gga gag act ggg aag aaa gga ccc ata gga cca aag gga gac aga      336
 Gln Gly Glu Thr Gly Lys Lys Gly Pro Ile Gly Pro Lys Gly Asp Arg
             100                 105                 110

 gga gaa caa ggg gac ccg ggg ctg cct gga gtt tgc aga tgt gga agc      384
 Gly Glu Gln Gly Asp Pro Gly Leu Pro Gly Val Cys Arg Cys Gly Ser
         115                 120                 125

 atc gtg ctc aaa tcc gcc ttt tct gtt ggc atc aca acc agc tac cca      432
 Ile Val Leu Lys Ser Ala Phe Ser Val Gly Ile Thr Thr Ser Tyr Pro
     130                 135                 140

 gaa gaa aga cta cct att ata ttt aac aag gtc ctc ttc aac gag gga      480
 Glu Glu Arg Leu Pro Ile Ile Phe Asn Lys Val Leu Phe Asn Glu Gly
 145                 150                 155                 160

 gag cac tac aac cct gcc aca ggg aag ttc atc tgt gct ttc cca ggg      528
 Glu His Tyr Asn Pro Ala Thr Gly Lys Phe Ile Cys Ala Phe Pro Gly
                 165                 170                 175

 atc tat tac ttt tct tat gat atc aca ttg gct aat aag cat ctg gca      576
 Ile Tyr Tyr Phe Ser Tyr Asp Ile Thr Leu Ala Asn Lys His Leu Ala
             180                 185                 190

 atc gga ctg gta cac aat ggg caa tac cgg ata aag acc ttc gac gcc      624
 Ile Gly Leu Val His Asn Gly Gln Tyr Arg Ile Lys Thr Phe Asp Ala
         195                 200                 205

 aac aca gga aac cat gat gtg gct tcg ggg tcc aca gtc atc tat ctg      672
 Asn Thr Gly Asn His Asp Val Ala Ser Gly Ser Thr Val Ile Tyr Leu
     210                 215                 220

 cag cca gaa gat gaa gtc tgg ctg gag att ttc ttc aca gac cag aat      720
 Gln Pro Glu Asp Glu Val Trp Leu Glu Ile Phe Phe Thr Asp Gln Asn
 225                 230                 235                 240

 ggc ctc ttc tca gac cca ggt tgg gca gac agc tta ttc tcc ggg ttt      768
 Gly Leu Phe Ser Asp Pro Gly Trp Ala Asp Ser Leu Phe Ser Gly Phe
                 245                 250                 255

 ctc tta tac gtt gac aca gat tac ata gat tcc ata tca gaa gat gat      816
 Leu Leu Tyr Val Asp Thr Asp Tyr Ile Asp Ser Ile Ser Glu Asp Asp
             260                 265                 270

 gaa ttg tga                                                          825
 Glu Leu 






      <210> 311
      <211> 1362
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (554)..(937)

      <400> 311
 agcagaagtt tcttcagtga ttttctcttt aagaaacatc atcacctcca tgtgccttac     60

 agaggccccc tgcgttctgc tgcattgctt ttgcgcactc ccttgatgat gaagatggtc    120

 ccaataatga tgcccaccag acccacagtc aggcccaggg cacacaccac gttctctgta    180

 gtctctggga gagggcttgg agcatcaaac tcccagtgct tgagaagagg ctcatccaag    240

 ccccagtgct ccaccctgca gtcgtaaacg tcctcagttg agggcaggaa ggggagatag    300

 tggaacttgc ggaaaaggtg gtcttctcaa agccacaggt cagggaccct cttgctgaat    360

 ttcccctccc cctgcctgac tgtggcctgg ctcctgcctc tcccttccaa acttgtcctc    420

 actgcaagga actccacact tttctgtttt tttggtctca gcagcaaagg agaaggaacc    480

 tgtcccctca gggattaagc aagcacagcc ctagttgatc acccagcatg aaaagtcctg    540

 gaatctctca gag   atg aac ctg tgt atg gga gtt ttg ctt aag tgg tac     589
                  Met Asn Leu Cys Met Gly Val Leu Leu Lys Trp Tyr
                    1               5                  10

 ttc aag aag gtg cct ctg ttt act ttg gtt ttg cac tgc cat gcg acc      637
 Phe Lys Lys Val Pro Leu Phe Thr Leu Val Leu His Cys His Ala Thr
          15                  20                  25

 agg tgg tgc agg tct ccc aaa tgc cac ccc cct cca agc ttc cct ctt      685
 Arg Trp Cys Arg Ser Pro Lys Cys His Pro Pro Pro Ser Phe Pro Leu
      30                  35                  40

 tgc tct aag tcc tca ggc ctc ctg ggc ctg gga cag atg gtt gtt tgt      733
 Cys Ser Lys Ser Ser Gly Leu Leu Gly Leu Gly Gln Met Val Val Cys
  45                  50                  55                  60

 gtc atc agg act cgt ggg gtt cta tgc gtg gag cac tca ccg cag cct      781
 Val Ile Arg Thr Arg Gly Val Leu Cys Val Glu His Ser Pro Gln Pro
                  65                  70                  75

 aag ctg gga tcc cag ctc aga ggt cag gcc atg ttg gga tgt tta ggg      829
 Lys Leu Gly Ser Gln Leu Arg Gly Gln Ala Met Leu Gly Cys Leu Gly
              80                  85                  90

 aag gtg atg cat tat cag gag aca tat cta ctg tcc cct gcc ctg tac      877
 Lys Val Met His Tyr Gln Glu Thr Tyr Leu Leu Ser Pro Ala Leu Tyr
          95                 100                 105

 ccc cag gca ttg atc tgg aga aca ttg tgt act aca agg acg aca ccc      925
 Pro Gln Ala Leu Ile Trp Arg Thr Leu Cys Thr Thr Arg Thr Thr Pro
     110                 115                 120

 act act ttg tga tga cagccaagaa gcagtgcctg ctgcggctgg gggtgctgcg      980
 Thr Thr Leu 
 125

 ccaggactgg cagacaccaa tcggctgctg ggcagtgcca atgtggtgcc cgaggctctg   1040

 cagcgcttta cccgggcagc tgctgacttt gccacccatg gcaggctcgg gaaactagag   1100

 tttgcccagg atgcccatgg gcagcctgat gtctctgcct ttgacttcac gagcatgatg   1160

 cgggcagaga gttctgctcg tgtgcaagag aagcatggcg cccgcctgct gctgggactg   1220

 gtgggggact gcctggtgga gcccttctgg taccctgggc actggagtgg cacggggctt   1280

 cctggcagcc tttgatgcag cctggatgtt gaagcggtgg gcagaggcgc tgagtcccta   1340

 gaggtgttgg ctgagcttta ca                                            1362




      <210> 312
      <211> 3506
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (300)..(3506)

      <400> 312
 ttcgctgtcg acgatttcgt gggagtaggg ctggactgtg accactgccc tggagagaag     60

 acagaaacag gacagaggat cccggctgca gccagcgtga ggaaagctct gctccctgcc    120

 agaccggcca gctgtggaaa cccagcgggg cttgcagcag agcggagggg cccaccccgt    180

 tcttcctcat ttcccacccc tggtgtggga tttggggggc tcctgggcag agtgcgaagc    240

 tccggagccg aggccactgg atccccagtg actgctcggg ggggtcccgc tgcgtggag     299                                                                 
 atg ccg gca gca cgt cgg ttc cct ggc ctg gag ctc tcc ttc cct ctc      347
 Met Pro Ala Ala Arg Arg Phe Pro Gly Leu Glu Leu Ser Phe Pro Leu
   1               5                  10                  15

 ctg gcc aga ctg cgg cga cgc ctg tac aca agg ctg gga ggc ggc aga      395
 Leu Ala Arg Leu Arg Arg Arg Leu Tyr Thr Arg Leu Gly Gly Gly Arg
              20                  25                  30

 atg cag cca gag gag ggc aca ggc tgg ctg ctg gag ctg ctg tcc gag      443
 Met Gln Pro Glu Glu Gly Thr Gly Trp Leu Leu Glu Leu Leu Ser Glu
          35                  40                  45

 gtg cag ctg caa cag tac ttc ctg cgg ctc cga gac gac ctc aac gtc      491
 Val Gln Leu Gln Gln Tyr Phe Leu Arg Leu Arg Asp Asp Leu Asn Val
      50                  55                  60

 acc cgc ctg tcc cac ttt gag tac gtc aag aat gag gac ctg gag aag      539
 Thr Arg Leu Ser His Phe Glu Tyr Val Lys Asn Glu Asp Leu Glu Lys
  65                  70                  75                  80

 atc ggc atg ggt cgg cct ggc cag cgg cgg ctg tgg gag gct gtg aag      587
 Ile Gly Met Gly Arg Pro Gly Gln Arg Arg Leu Trp Glu Ala Val Lys
                  85                  90                  95

 agg agg aag gcc ttg tgc aaa cgc aag tcg tgg atg agt aag gtg ttc      635
 Arg Arg Lys Ala Leu Cys Lys Arg Lys Ser Trp Met Ser Lys Val Phe
             100                 105                 110

 agt gga aag cga ctg gag gct gag ttc cca cct cat cac tct cag agc      683
 Ser Gly Lys Arg Leu Glu Ala Glu Phe Pro Pro His His Ser Gln Ser
         115                 120                 125

 acc ttc cgg aag acc tcg ccc gcc cct ggg ggc cca gca ggg gag ggg      731
 Thr Phe Arg Lys Thr Ser Pro Ala Pro Gly Gly Pro Ala Gly Glu Gly
     130                 135                 140

 ccc ctg cag agc ctc acc tgc ctc att ggg gag aag gac ctg cgc ctc      779
 Pro Leu Gln Ser Leu Thr Cys Leu Ile Gly Glu Lys Asp Leu Arg Leu
 145                 150                 155                 160

 ctg gag aag ctg ggt gat ggt tcc ttt ggc gtg gtg cgc agg ggc gag      827
 Leu Glu Lys Leu Gly Asp Gly Ser Phe Gly Val Val Arg Arg Gly Glu
                 165                 170                 175

 tgg gac gcg ccc tca ggg aag acg gtg agt gtg gct gtg aag tgc ctg      875
 Trp Asp Ala Pro Ser Gly Lys Thr Val Ser Val Ala Val Lys Cys Leu
             180                 185                 190

 aag ccc gat gtc ctg agc cag cca gaa gcc atg gac gac ttc atc cgg      923
 Lys Pro Asp Val Leu Ser Gln Pro Glu Ala Met Asp Asp Phe Ile Arg
         195                 200                 205

 gag gtc aat gcc atg cac tcg ctc gac cac cga aac ctc atc cgc ctc      971
 Glu Val Asn Ala Met His Ser Leu Asp His Arg Asn Leu Ile Arg Leu
     210                 215                 220

 tac ggg gtg gtg ctc acg ccg ccc atg aag atg gtg aca gag ctg gca     1019
 Tyr Gly Val Val Leu Thr Pro Pro Met Lys Met Val Thr Glu Leu Ala
 225                 230                 235                 240

 cct ctg gga tcg ttg ttg gac cgg cta cgt aag cac cag ggc cac ttc     1067
 Pro Leu Gly Ser Leu Leu Asp Arg Leu Arg Lys His Gln Gly His Phe
                 245                 250                 255

 ctc ctg ggg act ctg agc cgc tac gct gtg cag gtg gct gag ggc atg     1115
 Leu Leu Gly Thr Leu Ser Arg Tyr Ala Val Gln Val Ala Glu Gly Met
             260                 265                 270

 ggc tac ctg gag tcc aag cgc ttt att cac cgt gac ctg gct gcc cgc     1163
 Gly Tyr Leu Glu Ser Lys Arg Phe Ile His Arg Asp Leu Ala Ala Arg
         275                 280                 285

 aat ctg ctg ttg gct acc cgc gac ctg gtc aag atc ggg gac ttt ggg     1211
 Asn Leu Leu Leu Ala Thr Arg Asp Leu Val Lys Ile Gly Asp Phe Gly
     290                 295                 300

 ctg atg cga gca cta cct cag aat gac gac cat tac gtc atg cag gaa     1259
 Leu Met Arg Ala Leu Pro Gln Asn Asp Asp His Tyr Val Met Gln Glu
 305                 310                 315                 320

 cat cgc aag gtg ccc ttc gcc tgg tgt gcc ccc gag agc ctg aag aca     1307
 His Arg Lys Val Pro Phe Ala Trp Cys Ala Pro Glu Ser Leu Lys Thr
                 325                 330                 335

 cgc acc ttc tcc cat gcc agc gac acc tgg atg ttc ggg gtg aca ctg     1355
 Arg Thr Phe Ser His Ala Ser Asp Thr Trp Met Phe Gly Val Thr Leu
             340                 345                 350

 tgg gaa atg ttc acc tac ggc cag gag ccc tgg atc ggc ctc aac ggc     1403
 Trp Glu Met Phe Thr Tyr Gly Gln Glu Pro Trp Ile Gly Leu Asn Gly
         355                 360                 365

 agt cag atc ctg cat aag atc gac aag gag ggg gag cgg ctg ccc cgg     1451
 Ser Gln Ile Leu His Lys Ile Asp Lys Glu Gly Glu Arg Leu Pro Arg
     370                 375                 380

 ccc gag gac tgt ccc cag gac atc tac aac gtc atg gtc cag tgc tgg     1499
 Pro Glu Asp Cys Pro Gln Asp Ile Tyr Asn Val Met Val Gln Cys Trp
 385                 390                 395                 400

 gct cac aag cca gag gac aga ccc acg ttt gtg gcc ctg cgg gac ttc     1547
 Ala His Lys Pro Glu Asp Arg Pro Thr Phe Val Ala Leu Arg Asp Phe
                 405                 410                 415

 ctg ctg gag gcc cag ccc aca gac atg cgg gcc ctt cag gac ttt gag     1595
 Leu Leu Glu Ala Gln Pro Thr Asp Met Arg Ala Leu Gln Asp Phe Glu
             420                 425                 430

 gaa ccg gac aag ctg cac atc cag atg aat gat gtc atc acc gtc atc     1643
 Glu Pro Asp Lys Leu His Ile Gln Met Asn Asp Val Ile Thr Val Ile
         435                 440                 445

 gag gga agg gcc gag aac tac tgg tgg cgt ggc cag aac aca cgg acg     1691
 Glu Gly Arg Ala Glu Asn Tyr Trp Trp Arg Gly Gln Asn Thr Arg Thr
     450                 455                 460

 ctg tgt gtg ggg ccc ttc cct cgc aac gtg gtg acc tcc gtg gcc ggc     1739
 Leu Cys Val Gly Pro Phe Pro Arg Asn Val Val Thr Ser Val Ala Gly
 465                 470                 475                 480

 ctg tcg gcc cag gac atc agc cag ccc ctg cag aac agc ttc atc cac     1787
 Leu Ser Ala Gln Asp Ile Ser Gln Pro Leu Gln Asn Ser Phe Ile His
                 485                 490                 495

 aca ggg cat ggc gac agt gac ccc cgc cac tgc tgg ggc ttc ccg gac     1835
 Thr Gly His Gly Asp Ser Asp Pro Arg His Cys Trp Gly Phe Pro Asp
             500                 505                 510

 agg att gac gaa ctg tat ctg gga aac ccc atg gac ccc ccc gac ctc     1883
 Arg Ile Asp Glu Leu Tyr Leu Gly Asn Pro Met Asp Pro Pro Asp Leu
         515                 520                 525

 ctg agc gtg gaa ctg agc acc tcc cgg ccc ccc cag cat cta gga ggg     1931
 Leu Ser Val Glu Leu Ser Thr Ser Arg Pro Pro Gln His Leu Gly Gly
     530                 535                 540

 gtg aaa aaa cca acc tat gac cct gtg agc gag gac caa gac ccc ttg     1979
 Val Lys Lys Pro Thr Tyr Asp Pro Val Ser Glu Asp Gln Asp Pro Leu
 545                 550                 555                 560

 tcc agc gac ttc aag agg ctg ggc ctg cgg aag cca ggc ctg ccc cga     2027
 Ser Ser Asp Phe Lys Arg Leu Gly Leu Arg Lys Pro Gly Leu Pro Arg
                 565                 570                 575

 ggg ctg tgg ctg gcg aag ccc tcg gcg cgg gtg ccg ggc acc aag gcc     2075
 Gly Leu Trp Leu Ala Lys Pro Ser Ala Arg Val Pro Gly Thr Lys Ala
             580                 585                 590

 agc cga ggc agc ggg gct gag gtc acg ctc atc gac ttc ggt gag gag     2123
 Ser Arg Gly Ser Gly Ala Glu Val Thr Leu Ile Asp Phe Gly Glu Glu
         595                 600                 605

 ccc gtg gtc ccg gcc cta cgg ccc tgc ccg ccc tcc ctg gcg cag ctg     2171
 Pro Val Val Pro Ala Leu Arg Pro Cys Pro Pro Ser Leu Ala Gln Leu
     610                 615                 620

 gcc atg gac gcc tgc tcc ctg ctg gac gag acc ccg cct cag agc ccc     2219
 Ala Met Asp Ala Cys Ser Leu Leu Asp Glu Thr Pro Pro Gln Ser Pro
 625                 630                 635                 640

 acg cgg gca ctg ccc cgg ccc ctg cac ccc acg cct gtg gtg gac tgg     2267
 Thr Arg Ala Leu Pro Arg Pro Leu His Pro Thr Pro Val Val Asp Trp
                 645                 650                 655

 gac gca cgc ccg ctg ccc ccc ccg ccc gcc tat gac gac gtg gcc cag     2315
 Asp Ala Arg Pro Leu Pro Pro Pro Pro Ala Tyr Asp Asp Val Ala Gln
             660                 665                 670

 gat gag gat gac ttt gag atc tgc tcc atc aac agc acc ctc gtg ggc     2363
 Asp Glu Asp Asp Phe Glu Ile Cys Ser Ile Asn Ser Thr Leu Val Gly
         675                 680                 685

 gcg ggg gtc cct gcc ggg ccc agc cag ggc cag acc aac tac gcc ttt     2411
 Ala Gly Val Pro Ala Gly Pro Ser Gln Gly Gln Thr Asn Tyr Ala Phe
     690                 695                 700

 gtg cct gag cag gcg cgg ccg ccc cct ccc ctg gag gac aac ctg ttc     2459
 Val Pro Glu Gln Ala Arg Pro Pro Pro Pro Leu Glu Asp Asn Leu Phe
 705                 710                 715                 720

 ctc ccg ccc cag ggt ggg ggc aag ccg ccc agc tcc gca cag acc gca     2507
 Leu Pro Pro Gln Gly Gly Gly Lys Pro Pro Ser Ser Ala Gln Thr Ala
                 725                 730                 735

 gag atc ttc cag gcg cta cag cag gag tgc atg agg caa ctg cag gct     2555
 Glu Ile Phe Gln Ala Leu Gln Gln Glu Cys Met Arg Gln Leu Gln Ala
             740                 745                 750

 ccg ggc tcc ccg gcc ccc tct ccc agc ccg ggg ggt gac gac aag ccc     2603
 Pro Gly Ser Pro Ala Pro Ser Pro Ser Pro Gly Gly Asp Asp Lys Pro
         755                 760                 765

 cag gtg cct cct cgg gta ccc atc ccc cct cgg ccc acg cgc cca cac     2651
 Gln Val Pro Pro Arg Val Pro Ile Pro Pro Arg Pro Thr Arg Pro His
     770                 775                 780

 gtc cag ctg tct cca gcc ccc ccg ggc gag gag gag acc agc cag tgg     2699
 Val Gln Leu Ser Pro Ala Pro Pro Gly Glu Glu Glu Thr Ser Gln Trp
 785                 790                 795                 800

 cct gga cct gct tcc cct ccc cgg gtg cct ccg cgg gag ccc ctg tcc     2747
 Pro Gly Pro Ala Ser Pro Pro Arg Val Pro Pro Arg Glu Pro Leu Ser
                 805                 810                 815

 cct caa ggc tcg agg aca ccc agc ccc ctg gta cca cct ggc agc tcc     2795
 Pro Gln Gly Ser Arg Thr Pro Ser Pro Leu Val Pro Pro Gly Ser Ser
             820                 825                 830

 ccg ctg cca ccc cgg ctc tca agc tca cct ggg aag acc atg ccc acc     2843
 Pro Leu Pro Pro Arg Leu Ser Ser Ser Pro Gly Lys Thr Met Pro Thr
         835                 840                 845

 acc cag agc ttt gcc tca gac ccc aag tac gcc acc ccc cag gtg atc     2891
 Thr Gln Ser Phe Ala Ser Asp Pro Lys Tyr Ala Thr Pro Gln Val Ile
     850                 855                 860

 cag gcc cct ggc gcg ggt ggt ccc tgc atc ctg ccc atc gtc cgg gat     2939
 Gln Ala Pro Gly Ala Gly Gly Pro Cys Ile Leu Pro Ile Val Arg Asp
 865                 870                 875                 880

 ggc aag aag gtc agc agc acc cac tat tac ttg ctg ccc gag cga cca     2987
 Gly Lys Lys Val Ser Ser Thr His Tyr Tyr Leu Leu Pro Glu Arg Pro
                 885                 890                 895

 tcc tac ctg gag cgc tac cag cgc ttc ctg cgt gag gcc cag agc ccc     3035
 Ser Tyr Leu Glu Arg Tyr Gln Arg Phe Leu Arg Glu Ala Gln Ser Pro
             900                 905                 910

 gag gag cct acc ccc ctg cct gtg cct ctg ctg ctg ccc cca ccc agc     3083
 Glu Glu Pro Thr Pro Leu Pro Val Pro Leu Leu Leu Pro Pro Pro Ser
         915                 920                 925

 acc cca gcc ccc gcc gcc ccc acg gcc acc gtg cgg ccg atg ccc cag     3131
 Thr Pro Ala Pro Ala Ala Pro Thr Ala Thr Val Arg Pro Met Pro Gln
     930                 935                 940

 gct gcc ttg gac ccc aag gcc aac ttc tcc acc aac aac agc aac cca     3179
 Ala Ala Leu Asp Pro Lys Ala Asn Phe Ser Thr Asn Asn Ser Asn Pro
 945                 950                 955                 960

 ggg gcc cgg cca cca ccc ccg agg gcc act gct cgg ctg cca cag agg     3227
 Gly Ala Arg Pro Pro Pro Pro Arg Ala Thr Ala Arg Leu Pro Gln Arg
                 965                 970                 975

 ggc tgc cct ggc gat ggg cca gag gcg ggc cgg cca gca gac aag atc     3275
 Gly Cys Pro Gly Asp Gly Pro Glu Ala Gly Arg Pro Ala Asp Lys Ile
             980                 985                 990

 cag atg gcc atg gtg cat ggg gtg acc aca gag gag tgc cag gcg gcc     3323
 Gln Met Ala Met Val His Gly Val Thr Thr Glu Glu Cys Gln Ala Ala
         995                1000                1005

 ctg cag tgc cac ggc tgg agc gtg cag agg gct gcc cag tat ctg aag     3371
 Leu Gln Cys His Gly Trp Ser Val Gln Arg Ala Ala Gln Tyr Leu Lys
    1010                1015                1020

 gtg gag cag ctc ttc ggg ctg ggt ctg cgg ccc aga ggg gag tgc cac     3419
 Val Glu Gln Leu Phe Gly Leu Gly Leu Arg Pro Arg Gly Glu Cys His
1025                1030                1035                1040

 aaa gtg ctg gag atg ttc gac tgg aac ctg gag cag gcc ggc tgc cac     3467
 Lys Val Leu Glu Met Phe Asp Trp Asn Leu Glu Gln Ala Gly Cys His
                1045                1050                1055

 ctt ctg ggc tcc tgg ggc cct gcc cac cac aag cgc tga                 3506
 Leu Leu Gly Ser Trp Gly Pro Ala His His Lys Arg 
            1060                1065





      <210> 313
      <211> 1133
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (178)..(1128)

      <400> 313
 gattaaactt ctgttgaaac agcctaatct ttaaaagtct gatagcatta gtaaatggag     60

 tccaagacac aagctgggta taaaatctgt acttttgggg gacagatgca aaccatgtac    120

 taggaaatct tcctgttact attaaagtat ttagtcacta ttttaacatc aaagact       177                                                                 
 atg cag ttt cca aat gtc aaa ata ttt gac atg cta tct tcc ctt ttc      225
 Met Gln Phe Pro Asn Val Lys Ile Phe Asp Met Leu Ser Ser Leu Phe
   1               5                  10                  15

 tat ttc tac tta gta acc cag agt aac ttt tgg ttc aca gat gtg tgc      273
 Tyr Phe Tyr Leu Val Thr Gln Ser Asn Phe Trp Phe Thr Asp Val Cys
              20                  25                  30

 aag cca gat gct tct tgt gac caa gcc aga cca ccc cct gtg cag tct      321
 Lys Pro Asp Ala Ser Cys Asp Gln Ala Arg Pro Pro Pro Val Gln Ser
          35                  40                  45

 tac atg gat gct gct ttc ctt ctg gat gcc tcc cgg aac atg gga agt      369
 Tyr Met Asp Ala Ala Phe Leu Leu Asp Ala Ser Arg Asn Met Gly Ser
      50                  55                  60

 gct gaa ttt gaa gac ata aga gcc ttc ctt gga gca cta tta gat cac      417
 Ala Glu Phe Glu Asp Ile Arg Ala Phe Leu Gly Ala Leu Leu Asp His
  65                  70                  75                  80

 ttt gaa atc acc cca gag ccg gag act tct gtc act gga gac cgg gtg      465
 Phe Glu Ile Thr Pro Glu Pro Glu Thr Ser Val Thr Gly Asp Arg Val
                  85                  90                  95

 gcc cta ttg agc cat gct ccc ccc gac ttc cta ccc aac act cag aag      513
 Ala Leu Leu Ser His Ala Pro Pro Asp Phe Leu Pro Asn Thr Gln Lys
             100                 105                 110

 agt cca gtt aga gct gag ttc aat ctt acc acc tac aga agt aag cgc      561
 Ser Pro Val Arg Ala Glu Phe Asn Leu Thr Thr Tyr Arg Ser Lys Arg
         115                 120                 125

 ctc atg aag agg cat gtg cac gag tca gtt aaa caa cta aat gga gat      609
 Leu Met Lys Arg His Val His Glu Ser Val Lys Gln Leu Asn Gly Asp
     130                 135                 140

 gct ttt att ggt cat gcc tta cag tgg act ctg gac aat gta ttt tta      657
 Ala Phe Ile Gly His Ala Leu Gln Trp Thr Leu Asp Asn Val Phe Leu
 145                 150                 155                 160

 agt aca ccc aat ctg aga aga aac aaa gtc ata ttt gtg ata tct gct      705
 Ser Thr Pro Asn Leu Arg Arg Asn Lys Val Ile Phe Val Ile Ser Ala
                 165                 170                 175

 ggg gaa acc agc cac tta gat ggg gaa atc tta aag aag gaa tcc ttg      753
 Gly Glu Thr Ser His Leu Asp Gly Glu Ile Leu Lys Lys Glu Ser Leu
             180                 185                 190

 cga gcc aaa tgt cag gga tat gcc tta ttt gtg ttt tcc ctt ggc cct      801
 Arg Ala Lys Cys Gln Gly Tyr Ala Leu Phe Val Phe Ser Leu Gly Pro
         195                 200                 205

 att tgg gat gac aag gaa ctg gag gat ctc gcc agc cac cct ttg gat      849
 Ile Trp Asp Asp Lys Glu Leu Glu Asp Leu Ala Ser His Pro Leu Asp
     210                 215                 220

 cac cac ctg gtc cag ctt ggc cga att cat aaa cct gac cac agt tat      897
 His His Leu Val Gln Leu Gly Arg Ile His Lys Pro Asp His Ser Tyr
 225                 230                 235                 240

 ggt gtg aag ttt gtg aag tcc ttt ata aac tca atc agg cgt gca atc      945
 Gly Val Lys Phe Val Lys Ser Phe Ile Asn Ser Ile Arg Arg Ala Ile
                 245                 250                 255

 aac aaa tat cca cca ata aac tta aaa ata aag tgc aac aga ctt aac      993
 Asn Lys Tyr Pro Pro Ile Asn Leu Lys Ile Lys Cys Asn Arg Leu Asn
             260                 265                 270

 tct ata gat cca aag cag ccc cca cga cca ttc cga agc ttt gtt cct     1041
 Ser Ile Asp Pro Lys Gln Pro Pro Arg Pro Phe Arg Ser Phe Val Pro
         275                 280                 285

 gga cca ctt ata gct acc ctc aaa gaa gat gta tta cag aag gca aaa     1089
 Gly Pro Leu Ile Ala Thr Leu Lys Glu Asp Val Leu Gln Lys Ala Lys
     290                 295                 300

 ttc ttt caa gat aaa aaa tat ctt tca aga gta gca tga agtgg           1133
 Phe Phe Gln Asp Lys Lys Tyr Leu Ser Arg Val Ala 
 305                 310                 315





      <210> 314
      <211> 1999
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (186)..(1403)

      <400> 314
 actaagcttg cctaatttgc ttcagaattg gaagagggaa ttgcagcagg aaaatatgtg     60

 aagagttttt aaacccacaa attcttctta ctttagaatt agttgttaca ttggcaggaa    120

 aaaataaatg cagatgttgg accatgttgg aaaccttgtc aagacagtgg attgtctcac    180

 acaga    atg gaa atg tgg ctt ctg att ctg gtg gcg tat atg ttc cag     227
          Met Glu Met Trp Leu Leu Ile Leu Val Ala Tyr Met Phe Gln
            1               5                  10

 aga aat gtg aat tca gta cat atg cca act aaa gct gtg gac cca gaa      275
 Arg Asn Val Asn Ser Val His Met Pro Thr Lys Ala Val Asp Pro Glu
  15                  20                  25                  30

 gca ttc atg aat att agt gaa atc atc caa cat caa ggc tat ccc tgt      323
 Ala Phe Met Asn Ile Ser Glu Ile Ile Gln His Gln Gly Tyr Pro Cys
                  35                  40                  45

 gag gaa tat gaa gtc gca act gaa gat ggg tat atc ctt tct gtt aac      371
 Glu Glu Tyr Glu Val Ala Thr Glu Asp Gly Tyr Ile Leu Ser Val Asn
              50                  55                  60

 agg att cct cga ggc cta gtg caa cct aag aag aca ggt tcc agg cct      419
 Arg Ile Pro Arg Gly Leu Val Gln Pro Lys Lys Thr Gly Ser Arg Pro
          65                  70                  75

 gtg gtg tta ctg cag cat ggc cta gtt gga ggt gct agc aac tgg att      467
 Val Val Leu Leu Gln His Gly Leu Val Gly Gly Ala Ser Asn Trp Ile
      80                  85                  90

 tcc aac ctg ccc aac aat agc ctg ggc ttc att ctg gca gat gct ggt      515
 Ser Asn Leu Pro Asn Asn Ser Leu Gly Phe Ile Leu Ala Asp Ala Gly
  95                 100                 105                 110

 ttt gac gtg tgg atg ggg aac agc agg gga aac gcc tgg tct cga aaa      563
 Phe Asp Val Trp Met Gly Asn Ser Arg Gly Asn Ala Trp Ser Arg Lys
                 115                 120                 125

 cac aag aca ctc tcc ata gac caa gat gag ttc tgg gct ttc agt tat      611
 His Lys Thr Leu Ser Ile Asp Gln Asp Glu Phe Trp Ala Phe Ser Tyr
             130                 135                 140

 gat gag atg gct agg ttt gac ctt cct gca gtg ata aac ttt att ttg      659
 Asp Glu Met Ala Arg Phe Asp Leu Pro Ala Val Ile Asn Phe Ile Leu
         145                 150                 155

 cag aaa acg ggc cag gaa aag atc tat tat gtc ggc tat tca cag ggc      707
 Gln Lys Thr Gly Gln Glu Lys Ile Tyr Tyr Val Gly Tyr Ser Gln Gly
     160                 165                 170

 acc acc atg ggc ttt att gca ttt tcc acc atg cca gag ctg gct cag      755
 Thr Thr Met Gly Phe Ile Ala Phe Ser Thr Met Pro Glu Leu Ala Gln
 175                 180                 185                 190

 aaa atc aaa atg tat ttt gct tta gca ccc ata gcc act gtt aag cat      803
 Lys Ile Lys Met Tyr Phe Ala Leu Ala Pro Ile Ala Thr Val Lys His
                 195                 200                 205

 gca aaa agc ccc ggg acc aaa ttt ttg ttg ctg cca gat atg atg atc      851
 Ala Lys Ser Pro Gly Thr Lys Phe Leu Leu Leu Pro Asp Met Met Ile
             210                 215                 220

 aag gga ttg ttt ggc aaa aaa gaa ttt ctg tat cag acc aga ttt ctc      899
 Lys Gly Leu Phe Gly Lys Lys Glu Phe Leu Tyr Gln Thr Arg Phe Leu
         225                 230                 235

 aga caa ctt gtt att tac ctt tgt ggc cag gtg att ctt gat cag att      947
 Arg Gln Leu Val Ile Tyr Leu Cys Gly Gln Val Ile Leu Asp Gln Ile
     240                 245                 250

 tgt agt aat atc atg tta ctt ctg ggt gga ttc aac acc aac aat atg      995
 Cys Ser Asn Ile Met Leu Leu Leu Gly Gly Phe Asn Thr Asn Asn Met
 255                 260                 265                 270

 aac atg agc cga gca agt gta tat gct gcc cac act ctt gct gga aca     1043
 Asn Met Ser Arg Ala Ser Val Tyr Ala Ala His Thr Leu Ala Gly Thr
                 275                 280                 285

 tct gtg caa aat att cta cac tgg agc cag gca gtg aat tct ggt gaa     1091
 Ser Val Gln Asn Ile Leu His Trp Ser Gln Ala Val Asn Ser Gly Glu
             290                 295                 300

 ctc cgg gca ttt gac tgg ggg agt gag acc aaa aat ctg gaa aaa tgc     1139
 Leu Arg Ala Phe Asp Trp Gly Ser Glu Thr Lys Asn Leu Glu Lys Cys
         305                 310                 315

 aat cag cca act cct gta agg tac aga gtc aga gat atg acg gtc cct     1187
 Asn Gln Pro Thr Pro Val Arg Tyr Arg Val Arg Asp Met Thr Val Pro
     320                 325                 330

 aca gca atg tgg aca gga ggt cag gac tgg ctt tca aat cca aga gac     1235
 Thr Ala Met Trp Thr Gly Gly Gln Asp Trp Leu Ser Asn Pro Arg Asp
 335                 340                 345                 350

 gtg aaa atg ctg ctc tct gag gtg acc aac ctc atc tac cat aag aat     1283
 Val Lys Met Leu Leu Ser Glu Val Thr Asn Leu Ile Tyr His Lys Asn
                 355                 360                 365

 att cct gaa tgg gct cat gtg gat ttc atc tgg ggt ttg gat gct cct     1331
 Ile Pro Glu Trp Ala His Val Asp Phe Ile Trp Gly Leu Asp Ala Pro
             370                 375                 380

 cac cgt atg tac aat gaa atc atc cat ctg atg cag cag gag gag aca     1379
 His Arg Met Tyr Asn Glu Ile Ile His Leu Met Gln Gln Glu Glu Thr
         385                 390                 395

 caa cct ttc cca agg acg gcg tga ggccgtattg tgaagcatct gacactgacg    1433
 Gln Pro Phe Pro Arg Thr Ala 
     400                 405

 atcttatgac aacctcctga gggatggggc taggacccat gaaggcagaa ttatggagag   1493

 cagagaccta gtatacattt ttcagattcc ctgcacttgg cactaaatcc gacacttaca   1553

 tttacatttt ttttctgtaa attaaagtac ttattaggta aatagaggtt ttgtatgcta   1613

 ttatatattc taccatcttg aagggtaggt tttacctgat agccagaaaa tatctagaca   1673

 ttctctatat cattcaggta aatctcttta aaacacctat tgttttttct ataagccata   1733

 tttttggagc actaaagtaa aatggcaaat tgggacagat attgaggtct ggagtctgtg   1793

 gattattgtt gactttgaca aaataagcta gacattttca ccttgttgcc acagagacat   1853

 aacactacct caggaagctg agctgcttta aggacaacaa caacaaaatc agtgttacag   1913

 tatggatgaa atctatgtta agcattctca gaataaggcc aagttttata gttgcatctc   1973

 agggaagaaa attttatagg atgttc                                        1999




      <210> 315
      <211> 755
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (134)..(409)

      <400> 315
 aattaccggg ccgacccacg cgtccgcaca gtccagctcc atttggagga gcagagaatg     60

 ggagactgcc ccacagtgct ggaagctgcc gcacagactg aggtcgcctt gcggtgagga    120

 gggaaaggac ctg   atg gtg ccc tgc tct ggg ctc tgc ccc ctg gtg ggg     169
                  Met Val Pro Cys Ser Gly Leu Cys Pro Leu Val Gly
                    1               5                  10

 agc tgg cct ttt ttg tat tcc ctt ggc tgc agc tct tgg gcc aag ctc      217
 Ser Trp Pro Phe Leu Tyr Ser Leu Gly Cys Ser Ser Trp Ala Lys Leu
          15                  20                  25

 agc ttt ctc acc tgc tgc ctg tgg gtg gat ggt tcc agg cca gga cct      265
 Ser Phe Leu Thr Cys Cys Leu Trp Val Asp Gly Ser Arg Pro Gly Pro
      30                  35                  40

 gtt ttg agt gag cca gag ctt cag tcc agg ctc atg gac ttt gca cac      313
 Val Leu Ser Glu Pro Glu Leu Gln Ser Arg Leu Met Asp Phe Ala His
  45                  50                  55                  60

 ttc cat caa aaa tgt ggc aat ctt tgt act tct aat cag ttc cat gta      361
 Phe His Gln Lys Cys Gly Asn Leu Cys Thr Ser Asn Gln Phe His Val
                  65                  70                  75

 caa ata act gca tta ttt tgg tca gag tgt tac ttt ggt ggc ccc tga      409
 Gln Ile Thr Ala Leu Phe Trp Ser Glu Cys Tyr Phe Gly Gly Pro 
              80                  85                  90

 tggaccttgt ctcccagtgt ggtctccgtc acctgatggg cgtggaatat gactagatgg    469

 ggccagtgcc atgatggcag gaggggcttg ataaatgcct gcacatggag cttgacctct    529

 tggcatgttc tgctggcagc ccacatgtcg tactatgaga acttcaaaca catggagagg    589

 ccacatgggg gagaacggag gtgttctgtc agtagccccc atgagcccca gacaacagcc    649

 caccatgtga gtaatcatct tggtcagctc agtggaatag ctctagccag aatcaagtgt    709

 agcatagcca cccagctgag cccagtcccc tgtaggatca tgagtg                   755




      <210> 316
      <211> 589
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (40)..(549)

      <220>
      <221> misc_feature
      <222> (1)...(589)
      <223> n = a,t,c or g

      <400> 316
 cccgctgcag gcagcagcag cccccgcccg cgcanagnc   atg gag ctc tgg ggg      54
                                              Met Glu Leu Trp Gly
                                                1               5

 gcc tac ctc ctc ctc tgc ctc ttc tcc ctc ctg acc cag gtc acc acc      102
 Ala Tyr Leu Leu Leu Cys Leu Phe Ser Leu Leu Thr Gln Val Thr Thr
                  10                  15                  20

 gag cca cca acc cag aag ccc aag aag att gta aat gcc aag aaa gtc      150
 Glu Pro Pro Thr Gln Lys Pro Lys Lys Ile Val Asn Ala Lys Lys Val
              25                  30                  35

 tgc ctg aag ggg acc aag gtg cac atg aaa tgc ttt ctg gcc ttc acc      198
 Cys Leu Lys Gly Thr Lys Val His Met Lys Cys Phe Leu Ala Phe Thr
          40                  45                  50

 cag acg aag acc ttc cac gag gcc agc gag gac tgc atc tcg cgc ggg      246
 Gln Thr Lys Thr Phe His Glu Ala Ser Glu Asp Cys Ile Ser Arg Gly
      55                  60                  65

 ggc acc ctg agc acc cct cag act ggc tcg gag aac gac gcc ctg tat      294
 Gly Thr Leu Ser Thr Pro Gln Thr Gly Ser Glu Asn Asp Ala Leu Tyr
  70                  75                  80                  85

 gag tac ctg cgc cag agc gtg ggc aac gag gcc gag atc tgg ctg ggc      342
 Glu Tyr Leu Arg Gln Ser Val Gly Asn Glu Ala Glu Ile Trp Leu Gly
                  90                  95                 100

 ctc aac gac atg gcg gcc gag ggc acc tgg gtg gac atg acc ggc gcc      390
 Leu Asn Asp Met Ala Ala Glu Gly Thr Trp Val Asp Met Thr Gly Ala
             105                 110                 115

 cgc atc gcc tac aag aac tgg gag act gag atc acc gcg caa ccc gat      438
 Arg Ile Ala Tyr Lys Asn Trp Glu Thr Glu Ile Thr Ala Gln Pro Asp
         120                 125                 130

 ggc ggc aag acc gag aac tgc gcg gtc ctg tca ggc gcg gcc aac ggc      486
 Gly Gly Lys Thr Glu Asn Cys Ala Val Leu Ser Gly Ala Ala Asn Gly
     135                 140                 145

 aag tgg ttc gac aag cgc tgc cgc gat cag ctg ccc tac att tgc cag      534
 Lys Trp Phe Asp Lys Arg Cys Arg Asp Gln Leu Pro Tyr Ile Cys Gln
 150                 155                 160                 165

 ttc ggg atc gtg taa ccggcggggc gggggccgtg gggggcctgg aggagggcag      589
 Phe Gly Ile Val 






      <210> 317
      <211> 865
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (329)..(493)

      <400> 317
 tttctctgat cgctctagtc atcattgtga tgttcctggg cctcacatct gcataaacat     60

 taatccagtg gtctcaggac agagctgcct ggtggttcaa acacccactc tgggattttc    120

 agttaggttg ttgccaaatc ctcaggcagt gaaggtgtat gataactata tagagtagac    180

 atttacatag tattatgaca tgttagtgat aagagtatcg tgttaaccac atttatttga    240

 tttaattatc accaagcatc tcttttcatg taatatttta ctgtagactt tatacatagg    300

 cagtgtgttg catcaatatc agtgtagt   atg tgg aaa tct ttt aca gta gaa     352
                                  Met Trp Lys Ser Phe Thr Val Glu
                                    1               5

 gtg ttt tct ttt att tgg cgc aca ata gtc caa att tct tta atc ctt      400
 Val Phe Ser Phe Ile Trp Arg Thr Ile Val Gln Ile Ser Leu Ile Leu
      10                  15                  20

 ctt ttg cat gtt tgt ttt tca acc ctt tct gtt tct tcc gtc tct aga      448
 Leu Leu His Val Cys Phe Ser Thr Leu Ser Val Ser Ser Val Ser Arg
  25                  30                  35                  40

 atg gct ggc ttt tat tgt ata gca gtt ctg ttt gtt cgt ttt taa gaa      496
 Met Ala Gly Phe Tyr Cys Ile Ala Val Leu Phe Val Arg Phe 
                  45                  50

 gaactcagaa gagttgtatt gcctcaattt gtaaagctta aaaatgtttg cctttataat    556

 ttaagaacac cttggctagg tgacaagttt ttacttcttg tgagcggtag gccacaggag    616

 tatggtaaga gaagcaacag gacaaagagc ttgatcttgt tctcctttgt tgtggagccc    676

 ttacatgttt taaacatgaa ctacttagca acaattccat gtttctttag gggaaaatag    736

 caaccagaac aaaacaccag aaacacacaa taatatcttt attaccttga agtacacaaa    796

 gatcttaaaa acaaacaaac aaaaaaccaa gacataaaaa ttactaccat aaaaggggaa    856

 aaaatgtgg                                                            865




      <210> 318
      <211> 598
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (72)..(365)

      <400> 318
 catctgttct tatgccagaa ctacactgtt ttgactatgt agttttgtag gaagttttga     60

 aatcagaaag t atg aat cct cca gct ttg tgc atc ttt tca aag act gct     110
              Met Asn Pro Pro Ala Leu Cys Ile Phe Ser Lys Thr Ala
                1               5                  10

 ttg gct att tgg ggt cct tta ata ttc cat atg aat ttt cag atg ggt      158
 Leu Ala Ile Trp Gly Pro Leu Ile Phe His Met Asn Phe Gln Met Gly
      15                  20                  25

 ttt tct gtt tct gta aaa aat gtg att ggg act ttg gta agg ggc gca      206
 Phe Ser Val Ser Val Lys Asn Val Ile Gly Thr Leu Val Arg Gly Ala
  30                  35                  40                  45

 ttg cat cct tgc tcc ggt gat cac ttt ggg tgg gat tgt cat cta aac      254
 Leu His Pro Cys Ser Gly Asp His Phe Gly Trp Asp Cys His Leu Asn
                  50                  55                  60

 att gtc cca atc cat gaa cat gaa tgt ctt tct gta ggt ggg tta ttt      302
 Ile Val Pro Ile His Glu His Glu Cys Leu Ser Val Gly Gly Leu Phe
              65                  70                  75

 aaa aaa aaa aac tcc cta tgt gaa aat ggt cct tgg ata tta ata aaa      350
 Lys Lys Lys Asn Ser Leu Cys Glu Asn Gly Pro Trp Ile Leu Ile Lys
          80                  85                  90

 agt caa att att tag ccatgtcaca gggaggaagg acccatttct cccggttcac      405
 Ser Gln Ile Ile 
      95

 tactcattgg aacccctgtt aagttctggg gaacattttc tgggaccctt cttcaattta    465

 cataattggg tcattttccc catttaaagg taaagtggtt ccggtgcatg gctggataaa    525

 taggttgccc acattactta gcaactcctt gtaggtttaa ttgttctgga gctgaggaat    585

 ttttaaacaa gta                                                       598




      <210> 319
      <211> 548
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (30)..(260)

      <400> 319
 tttcgtccca gacttcaggc gccttcacg  atg ccg gcg gtc agt ggt cca ggt      53
                                  Met Pro Ala Val Ser Gly Pro Gly
                                    1               5

 ccc tta ttc tgc ctt ctc ctc ctg ctc ctg gac ccc cac agc cct gag      101
 Pro Leu Phe Cys Leu Leu Leu Leu Leu Leu Asp Pro His Ser Pro Glu
      10                  15                  20

 acg ggg tgt cct cct cta cgc agg ttt gag tac aag ctc agc ttc aaa      149
 Thr Gly Cys Pro Pro Leu Arg Arg Phe Glu Tyr Lys Leu Ser Phe Lys
  25                  30                  35                  40

 ggc cca agg ctg gca ttg cct ggg gct gga ata ccc ttc tgg agc cat      197
 Gly Pro Arg Leu Ala Leu Pro Gly Ala Gly Ile Pro Phe Trp Ser His
                  45                  50                  55

 cat gga gga ctt ctc tct tct cct ctg cct ctc ctt gga ccc ctg ccc      245
 His Gly Gly Leu Leu Ser Ser Pro Leu Pro Leu Leu Gly Pro Leu Pro
              60                  65                  70

 ttc ctc tac ctc tga cctgtgaaca cacagacaca tgctcacaca ctaagtccca      300
 Phe Leu Tyr Leu 
          75

 ggcacacaga aggcaatgtg gaccagcaca aacctccact ctcccggctc catcccagcg    360

 ggcctgtggc tggccatgag aactgggggc tacctggagg gaagcatcct catcccagac    420

 gccatcctgg gcctggagga agtgcggctg acgccatcca tgaggaaccg gagtggcgcc    480

 gtgtggagca gggcctctgt ccccttctct gcctgggaag tagaggtgca gatgatggtg    540

 acgggact                                                             548




      <210> 320
      <211> 815
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (159)..(344)

      <400> 320
 atgttagaca atttttaatt catcctctct gtgctgttgt tttctcagct gtgaaaggaa     60

 tattctggtg gggacaaggt tacagagttg ctgagagggt ctcatgacat gaaggtactg    120

 gccttggcac agtgcctggg ggggcgggga ctccgcac    atg cct gtg atg tca     173
                                              Met Pro Val Met Ser
                                                1               5

 cag tta ctg tca gtt cac agc gaa cct tcc ctc ctt ttc ctg ttg act      221
 Gln Leu Leu Ser Val His Ser Glu Pro Ser Leu Leu Phe Leu Leu Thr
                  10                  15                  20

 ttc cca cac tcc tgt aac cct ccc tcc ctc cct tct tcc tct ctc tct      269
 Phe Pro His Ser Cys Asn Pro Pro Ser Leu Pro Ser Ser Ser Leu Ser
              25                  30                  35

 ctc tca ctc acg cac acg cac aca cac aca cac aca cac agc aca cac      317
 Leu Ser Leu Thr His Thr His Thr His Thr His Thr His Ser Thr His
          40                  45                  50

 act cac att tct cgt gtc cta cag tga ctctg gaaagtacca aataactgtc      369
 Thr His Ile Ser Arg Val Leu Gln 
      55                  60

 tcgatggcag cacaattgga agcccacatt gctcactcca tttgtgaaag tgtatcgcgt    429

 cgtgctcgca gaagacgggg tctcagctca ttcgctaccc ccgggggcgt ggacgtggga    489

 gagcggtggc cgcctcaacg cgcaccacaa gcgccaaaca aatcacgacc acacacaaca    549

 gggaccaaga ccgagacaga accagacgca gcacacaaca aacaacatcc gcagaaagcc    609

 cacgtgatgc agccacaaaa aagcgacaga gagagcacac acacaaacca aaccagaaac    669

 aacacacgac gatgataaca acaggaagag agaagacggg agcgaagaca acacaacaga    729

 gagcgaacaa caagaggagg gaaaacaaac aagcccacgc acaccccaac cagacaacag    789

 acaaaagaca acgcacagcc caccca                                         815




      <210> 321
      <211> 612
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (392)..(562)

      <400> 321
 gcgtaatcat ttatataggc tttccataag tattgctgaa actactatgg cttatttatc     60

 ttctttaata tttgtaaaag tcttactcct ttgttagttt tgtttctgca caactactgt    120

 acttttccat atgaaataaa gactattaat agaatgtgtt ttgcactaaa tgagtcaatg    180

 gataagtaga gaacagtctg atgacagcta tctctgttgc ttttaatctt tgttacccta    240

 gagggaatag tgaaaagcat attttatatt aacactacaa aatgcttatt taatttcgtt    300

 ttataatttc agaataaggg tgacagctgc tagaaattcc acaatactca agggccaaat    360

 ttagtctttt tgcctcaaat agaaagaaag c   atg cag gaa agc aat ata tac     412
                                      Met Gln Glu Ser Asn Ile Tyr
                                        1               5

 ttc cta tct atc tgt ttc aag aca tct tgg tgt ctg ttt tta ctg gca      460
 Phe Leu Ser Ile Cys Phe Lys Thr Ser Trp Cys Leu Phe Leu Leu Ala
          10                  15                  20

 acg gga cat ctt tac tac tgt aat tct caa aca ctt tgg caa tac act      508
 Thr Gly His Leu Tyr Tyr Cys Asn Ser Gln Thr Leu Trp Gln Tyr Thr
      25                  30                  35

 gaa cac tgt tat gac agt ttg ttc ttt aac aca ttt gta tta tct ttc      556
 Glu His Cys Tyr Asp Ser Leu Phe Phe Asn Thr Phe Val Leu Ser Phe
  40                  45                  50                  55

 agt taa aagtatgtct ttatgcctac atatttcaaa gtaatatgag agagaacatt       612
 Ser 






      <210> 322
      <211> 703
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (173)..(421)

      <400> 322
 cgccaagaat tcggcacgag gaaatttaca aaaattagaa agctactaca tgaaaatata     60

 acatttatgt caaacaacag gaaatttttt tcaggagtat agataaaaag tttccagtga    120

 attttttttt ccccacagtt ttttttcttc ccacccacta ctcaaggtag tt    atg     175
                                                              Met
                                                                1

 aat gtt act gct att tgg tta cac aga gat aag tta ttt tgc tgg tta      223
 Asn Val Thr Ala Ile Trp Leu His Arg Asp Lys Leu Phe Cys Trp Leu
               5                  10                  15

 gtt att tct tat att tct gaa ata tgc tta agt gaa tgt tgg att aaa      271
 Val Ile Ser Tyr Ile Ser Glu Ile Cys Leu Ser Glu Cys Trp Ile Lys
          20                  25                  30

 ata gct gtc ttt aaa aac tct cta ttt aaa aat gtc tta caa tac tac      319
 Ile Ala Val Phe Lys Asn Ser Leu Phe Lys Asn Val Leu Gln Tyr Tyr
      35                  40                  45

 att ctt aca gac ctg tgt ctg agc caa tta ttg atg aat aat ttg tat      367
 Ile Leu Thr Asp Leu Cys Leu Ser Gln Leu Leu Met Asn Asn Leu Tyr
  50                  55                  60                  65

 agt tta gaa agt tat ata aaa ggc tat ttt tca ttt tgt tgg gga gat      415
 Ser Leu Glu Ser Tyr Ile Lys Gly Tyr Phe Ser Phe Cys Trp Gly Asp
                  70                  75                  80

 ggt tag ttaaatatgt tttatatttt taaaacatat ctttttggcc ttgcttatgc       471
 Gly 


 aaaggtaata gggaaaggta cttacttttt aaatttgggt aaattgtaag tttgcgggag    531

 gcggcggact ggcgttattt ttgcatggat tccgaactct ctggttactt gggtaaaatt    591

 atttccacag ggagaagaat gtcttaggcg ccacaagata atggccattt gcgcagaaga    651

 aaacttctgt tccctttgcc acaaggattt agaaaacttt tatattttta ac            703




      <210> 323
      <211> 856
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (445)..(666)

      <400> 323
 ggtaatctgt gtcccttata aatggcaggc tctcttccca ctccttggct tcctttccct     60

 tattccagtc tgatgctaat ccctcttgct tcctcaggga ccttgcttca ttgtcttttc    120

 ttcagggtct caatgatcct tttctttcaa catataaaca tgcataagtc tttcatattc    180

 tttatgaaaa cagaaaacga tgaacgcttt tggtcgcttc tctctaggtt tgggtgtgtt    240

 tcatcttatt cctggtctta gcaggcagct ccttgaagta caggtcctcg tacacatccc    300

 gcacctcgcc atcttccttt catcttcaac cccctgcact cctgtcctct cctaatgacc    360

 accaggtcca ttatctagga ttctctttca tttcttgaac tttgcacaac atttggtgtt    420

 cttgaccact ctctgctcct taaa   atg ttg ccc acc tgt ttt ctg agt tat     471
                              Met Leu Pro Thr Cys Phe Leu Ser Tyr
                                1               5

 cca ttt ctc ctc att ttc ttt ctt gtc cag ctg ctc tat att tgg act      519
 Pro Phe Leu Leu Ile Phe Phe Leu Val Gln Leu Leu Tyr Ile Trp Thr
  10                  15                  20                  25

 tct ctt tac tgt cct ccc ttc ctc tca aac ctt agc ctc ccc tac agt      567
 Ser Leu Tyr Cys Pro Pro Phe Leu Ser Asn Leu Ser Leu Pro Tyr Ser
                  30                  35                  40

 tca gcc ctc agc cct ctg ctc att ctg cac gtt tgc cct gtg gca gct      615
 Ser Ala Leu Ser Pro Leu Leu Ile Leu His Val Cys Pro Val Ala Ala
              45                  50                  55

 cat ctt ctg ttt tct tct act acc acc tat atg cca ttg att cca ttg      663
 His Leu Leu Phe Ser Ser Thr Thr Thr Tyr Met Pro Leu Ile Pro Leu
          60                  65                  70

 taa atct gcatctccag ccttgaaatc ttatctgaca tgtgttccaa atgtctttaa      720
 


 ctcgacaagt tcaaaacatc acttccccaa cttcaatcca gcatactcct tctgtgttgt    780

 ctatcacaat gaatagaacg tgcttccacg agtttcaagc acagcaatac taactctgcc    840

 tggcagttgg ggccca                                                    856




      <210> 324
      <211> 864
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (206)..(376)

      <220>
      <221> misc_feature
      <222> (1)...(864)
      <223> n = a,t,c or g

      <400> 324
 gtcagggctg tgcttggact tggaattgaa ataagtcctg gaaaattggt taatccccgc     60

 ttggcataca tattatgtaa agtgtgttgg gagaggtact tgaaggtttt cctgttgaaa    120

 taaattccct acaaccttag ccttccagtc cctctgcctg acactcccat ggcagttggt    180

 gcacttgcgt tttgccctgt tgaag  atg cct gtg cca tta gct cgc att tgt     232
                              Met Pro Val Pro Leu Ala Arg Ile Cys
                                1               5

 tgg gta tct ttc ttg cac cag gca cca tgc tgg gaa cta tgc tat tac      280
 Trp Val Ser Phe Leu His Gln Ala Pro Cys Trp Glu Leu Cys Tyr Tyr
  10                  15                  20                  25

 tgc gtg gtc ctc aca tca gct ctg ata ggt gct gtt aat agc tcc atc      328
 Cys Val Val Leu Thr Ser Ala Leu Ile Gly Ala Val Asn Ser Ser Ile
                  30                  35                  40

 tta cag atg act gga tct aca ggg aga tta gac agt tgg cca tgg tga      376
 Leu Gln Met Thr Gly Ser Thr Gly Arg Leu Asp Ser Trp Pro Trp 
              45                  50                  55

 cagtgaactt agttcttggg tcattgctcc tggagcctat gcattataga cctgctggtg    436

 tgagctcttt ctcctcattc atctgagaag acttctgtgt ctgcatttgc ctcttcctat    496

 gttagtaaaa ggaacatttt tccactggaa aacagttacc aacagttttg tcagtggcta    556

 ctctattata ccttcaaaca tgcctaaatc ttatgtaact caacacccag ttaatcttgc    616

 tatctattct agccactctt cttgtttttc tctctttaaa ctccccaaca ggcagtctgt    676

 ttccattgcc tccaccatct atcctatcct ttctctggag atcttgttcc tgttgnctca    736

 gntatatttt cagcttcttc attttgctaa tggaaacatc tatcctggtc attgtagtaa    796

 attaggggct tggcatggtg actcatgcct gttgtcttag cactttgaga ggctaaagcg    856

 gaaaagcg                                                             864




      <210> 325
      <211> 694
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (63)..(275)

      <400> 325
 ctttcagttc ccgtcgtgag aagaagctga accggaagtt ggtaagccga ggtctgccca     60

 cc   atg gta ctg tgt tct tca gcc ttc tta act gtg cag tgg gga gga     107
      Met Val Leu Cys Ser Ser Ala Phe Leu Thr Val Gln Trp Gly Gly
        1               5                  10                  15

 gag gca tca gat aat att tac ctt gct ttc tac ttt tca gtc tgt ggt      155
 Glu Ala Ser Asp Asn Ile Tyr Leu Ala Phe Tyr Phe Ser Val Cys Gly
                  20                  25                  30

 ttt aca atc tcc ctg act ctc acc cca tcc agg cat ctg aaa ggt tgt      203
 Phe Thr Ile Ser Leu Thr Leu Thr Pro Ser Arg His Leu Lys Gly Cys
              35                  40                  45

 gtg gaa gca agg ttg agt gag agt ggg gag ggg gag aaa ggg tgg cag      251
 Val Glu Ala Arg Leu Ser Glu Ser Gly Glu Gly Glu Lys Gly Trp Gln
          50                  55                  60

 gag ggt ttg gtt tct ggg gcc tga gtaactctgg ccttgaacat tcccgcgatc     305
 Glu Gly Leu Val Ser Gly Ala 
      65                  70

 ccgacagatt cccaggtgga ataaagacct gggggcccca gtggctgcta gaaagggctg    365

 accaggggtc ttcccctttt gactaacatg tgttggaaat aaggggtctg tgatatataa    425

 ggaatttctc tctccctctg tctactggga agatattcgc catattatat ggagaccctc    485

 actggagtag aaaaggaaaa ggctttgagg acaagttact tccatgtttt tatcgaggaa    545

 actaaactgt ctgcagccat gcttatatgt ctccaccaag atgtacacct cacgccttct    605

 cctttttctg ggtctgagtg atctttcttg cctagatata ctcggagctg gaaccacagc    665

 ggggctcctg caagttcaga tattatttt                                      694




      <210> 326
      <211> 1592
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (25)..(1182)

      <220>
      <221> misc_feature
      <222> (1)...(1592)
      <223> n = a,t,c or g

      <400> 326
 ggcacgagga aaatcaagat aaaa   atg ttc aca att aag ctc ctt ctt ttt      51
                              Met Phe Thr Ile Lys Leu Leu Leu Phe
                                1               5

 att gtt cct cta gtt att tcc tcc aga att gat caa gac aat tca tca       99
 Ile Val Pro Leu Val Ile Ser Ser Arg Ile Asp Gln Asp Asn Ser Ser
  10                  15                  20                  25

 ttt gat tct cta tct cca gag cca aaa tca aga ttt gct atg tta gac      147
 Phe Asp Ser Leu Ser Pro Glu Pro Lys Ser Arg Phe Ala Met Leu Asp
                  30                  35                  40

 gat gta aaa att tta gcc aat ggc ctc ctt cag ttg gga cat ggt ctt      195
 Asp Val Lys Ile Leu Ala Asn Gly Leu Leu Gln Leu Gly His Gly Leu
              45                  50                  55

 aaa gac ttt gtc cat aag acg aag ggc caa att aat gac ata ttt caa      243
 Lys Asp Phe Val His Lys Thr Lys Gly Gln Ile Asn Asp Ile Phe Gln
          60                  65                  70

 aaa ctc aac ata ttt gat cag tct ttt tat gat cta tcg ctg caa acc      291
 Lys Leu Asn Ile Phe Asp Gln Ser Phe Tyr Asp Leu Ser Leu Gln Thr
      75                  80                  85

 agt gaa atc aaa gaa gaa gaa aag gaa ctg aga aga act aca tat aaa      339
 Ser Glu Ile Lys Glu Glu Glu Lys Glu Leu Arg Arg Thr Thr Tyr Lys
  90                  95                 100                 105

 cta caa gtc aaa aat gaa gag gta aag aat atg tca ctt gaa ctc aac      387
 Leu Gln Val Lys Asn Glu Glu Val Lys Asn Met Ser Leu Glu Leu Asn
                 110                 115                 120

 tca aaa ctt gaa agc ctc cta gaa gaa aaa att cta ctt caa caa aaa      435
 Ser Lys Leu Glu Ser Leu Leu Glu Glu Lys Ile Leu Leu Gln Gln Lys
             125                 130                 135

 gtg aaa tat tta gaa gag caa cta act aac tta att caa aat caa cct      483
 Val Lys Tyr Leu Glu Glu Gln Leu Thr Asn Leu Ile Gln Asn Gln Pro
         140                 145                 150

 gaa act cca gaa cac cca gaa gta act tca ctt aaa act ttt gta gaa      531
 Glu Thr Pro Glu His Pro Glu Val Thr Ser Leu Lys Thr Phe Val Glu
     155                 160                 165

 aaa caa gat aat agc atc aaa gac ctt ctc cag acc gtg gaa gac caa      579
 Lys Gln Asp Asn Ser Ile Lys Asp Leu Leu Gln Thr Val Glu Asp Gln
 170                 175                 180                 185

 tat aaa caa tta aac caa cag cat agt caa ata aaa gaa ata gaa aat      627
 Tyr Lys Gln Leu Asn Gln Gln His Ser Gln Ile Lys Glu Ile Glu Asn
                 190                 195                 200

 cag ctc aga agg act agt att caa gaa ccc aca gaa att tct cta tct      675
 Gln Leu Arg Arg Thr Ser Ile Gln Glu Pro Thr Glu Ile Ser Leu Ser
             205                 210                 215

 tcc aag cca aga gca cca aga act act ccc ttt ctt cag ttg aat gaa      723
 Ser Lys Pro Arg Ala Pro Arg Thr Thr Pro Phe Leu Gln Leu Asn Glu
         220                 225                 230

 ata aga aat gta aaa cat gat ggc att cct gct gaa tgt acc acc att      771
 Ile Arg Asn Val Lys His Asp Gly Ile Pro Ala Glu Cys Thr Thr Ile
     235                 240                 245

 tat aac aga ggt gaa cat aca agt ggc atg tat gcc atc aga ccc agc      819
 Tyr Asn Arg Gly Glu His Thr Ser Gly Met Tyr Ala Ile Arg Pro Ser
 250                 255                 260                 265

 aac tct caa gtt ttt cat gtc tac tgt gat gtt ata tca ggt agt cca      867
 Asn Ser Gln Val Phe His Val Tyr Cys Asp Val Ile Ser Gly Ser Pro
                 270                 275                 280

 tgg aca tta att caa cat cga ata gat gga tca cga gaa att tgg atg      915
 Trp Thr Leu Ile Gln His Arg Ile Asp Gly Ser Arg Glu Ile Trp Met
             285                 290                 295

 ggc cta gag aag ata tac tcc ata gtg aag caa tct aat tat gtt tta      963
 Gly Leu Glu Lys Ile Tyr Ser Ile Val Lys Gln Ser Asn Tyr Val Leu
         300                 305                 310

 cga att gag ttg gaa gac tgg aaa gac aac aaa cat tat att gaa tat     1011
 Arg Ile Glu Leu Glu Asp Trp Lys Asp Asn Lys His Tyr Ile Glu Tyr
     315                 320                 325

 tct ttt tac ttg gga aat cac gaa acc aac tat acg cta cat cta gtt     1059
 Ser Phe Tyr Leu Gly Asn His Glu Thr Asn Tyr Thr Leu His Leu Val
 330                 335                 340                 345

 gcg att act ggc aat gtc ccc aat gca atc ccg gaa aac aaa gat ttg     1107
 Ala Ile Thr Gly Asn Val Pro Asn Ala Ile Pro Glu Asn Lys Asp Leu
                 350                 355                 360

 gtg ttt tct act tgg gat cac aaa gca aaa gga cac ttc aac tgt cca     1155
 Val Phe Ser Thr Trp Asp His Lys Ala Lys Gly His Phe Asn Cys Pro
             365                 370                 375

 gag ggt tat tca ggt atc ttt ttc tga tacca atactttatt ttcatatctt     1207
 Glu Gly Tyr Ser Gly Ile Phe Phe 
         380                 385

 caaagtatct tcccacatta ttagctatta tctgcaatga caacttttaa aaatccgaat   1267

 cccaaataag cgttttctct ctagacgaaa acctcttaac tataatgaaa gtgttcattc   1327

 tagttcaatc aggtatttta cctctaatct tcctcagatt ttctattttt tggtagtgta   1387

 tagattattt atacagatta tttaaaatta ggacttatac agattattta aaactgggtt   1447

 acatgcatct aaaacactgt aatatttata agaaaggaag ataaacttgc ggggaaatac   1507

 agtaacagta actacatacg agacctgccc gggcgaccgc tcgagcctta tagtgagtaa   1567

 tcccncgtcc atccgggcgg tagct                                         1592




      <210> 327
      <211> 701
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (238)..(399)

      <400> 327
 ggggcgagca tttttgagga caggttttcc gcagagcgcc taggcccggc ccaggcattt     60

 ccttattttc cgacgggtcc tcggattcct gacggatgag cttttgtttc gcaggacaaa    120

 aacttgacat aactgcataa gaattgtcga ttgcaacttt aaaaacctta ctgtattttc    180

 tgaaaaggtg ttctgtaaag tatctaggct tttactacgc tcttaaattg cttaaat       237                                                                 
 atg gag ata aca aag agt tgg ttt gtt ttc ttg tgg ctt ata aag ttc      285
 Met Glu Ile Thr Lys Ser Trp Phe Val Phe Leu Trp Leu Ile Lys Phe
   1               5                  10                  15

 ctt gaa aac aga gat acc tat gtc agt ttc ttt gct gat tta aaa aaa      333
 Leu Glu Asn Arg Asp Thr Tyr Val Ser Phe Phe Ala Asp Leu Lys Lys
              20                  25                  30

 att gta aga gaa att agg ggt gta ata atc atc agt tca gca ctt gcg      381
 Ile Val Arg Glu Ile Arg Gly Val Ile Ile Ile Ser Ser Ala Leu Ala
          35                  40                  45

 aga att atg aga aac tag tccacc taatagctta aatctgctgg gttttttgga      435
 Arg Ile Met Arg Asn 
      50

 gtttctttgg atagccagct tcagacttga attgaaacgc catccattga ggcttttact    495

 tggctaataa ctaatattag ccaataataa tattagccag tgtgatcata atgaggggca    555

 atatttattt tgtgctttct atgcgctggg cgtattaaga gctttacttt gggatatata    615

 ctgtgggccc cattttgaca gtgaagaaac taaggcgcag gaaattttag tattggaact    675

 tttgtaccgc acaggggtac acagca                                         701




      <210> 328
      <211> 382
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (76)..(213)

      <400> 328
 cggcacgagg tgattaagta ataagaaata cagtgatggg atcagtagca cagagtctca     60

 tcgttttgtg atttc atg tct gtg ttt ttc ttg tct tgc ctg atc tta ccc     111
                  Met Ser Val Phe Phe Leu Ser Cys Leu Ile Leu Pro
                    1               5                  10

 caa cca gga ccc att gct gcc gga gtg agg tgt tac tcc tgg acc cct      159
 Gln Pro Gly Pro Ile Ala Ala Gly Val Arg Cys Tyr Ser Trp Thr Pro
          15                  20                  25

 ccg ctg gtc cgt gga gac ttg gct ggc aaa gtt gca tgt gac gta cat      207
 Pro Leu Val Arg Gly Asp Leu Ala Gly Lys Val Ala Cys Asp Val His
      30                  35                  40

 cct tag ttccctgagt ggcctcatgc aggagctgca tagggttact ctgattttgg       263
 Pro 
  45

 gatatcccgt gaataatcac aagtggcatt ttctctttca ttacctgtgt aatgtataag    323

 gagacttcaa aacggttgtg gaaaaatgga attgactgat ataatgctgg gtgtggtgg     382




      <210> 329
      <211> 794
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (115)..(330)

      <400> 329
 gatgaataat gtacactttt aatttaatga aatcaaatag attttaacta tctatgctta     60

 caatggggtg acataagtct gacaatcctt aatatcaagt catctccaat tcac  atg     117
                                                              Met
                                                                1

 tat aca cac ttt ttt tct att tgg cta ttg gga atc ctc aca aaa atc      165
 Tyr Thr His Phe Phe Ser Ile Trp Leu Leu Gly Ile Leu Thr Lys Ile
               5                  10                  15

 gaa aat tgc cct ttc agt gta cgt tac ggt att tca tgc cac aca gat      213
 Glu Asn Cys Pro Phe Ser Val Arg Tyr Gly Ile Ser Cys His Thr Asp
          20                  25                  30

 ttt ctg agg ttg tac ata cag ctt tgc ctt gag gtt cca att ttt gct      261
 Phe Leu Arg Leu Tyr Ile Gln Leu Cys Leu Glu Val Pro Ile Phe Ala
      35                  40                  45

 cag tgg att gag tat ata tta ttt gct ata tat cag aag agg cat gtg      309
 Gln Trp Ile Glu Tyr Ile Leu Phe Ala Ile Tyr Gln Lys Arg His Val
  50                  55                  60                  65

 ctt cct act tat gtc agg taa ct ttgggattaa taattgtcct acaaagcata      362
 Leu Pro Thr Tyr Val Arg 
                  70

 gatagataga aatacttcat ccttaatttc taatattatg acatatctaa agtaggcacc    422

 tttaaaagtt aatctccact aaatactaat gactgcttat agtggcaatt catctttcat    482

 ggtagtcctc ctacaaaggt atactaacat ttatgagttt gaaacaaagg caattcacaa    542

 gtgttctgct agagatggtc tatatctgct gtttgatcca gcatgatggc cagctggccc    602

 tcctgtgcat gacggctcgt ggtttaactg caccattttg tttggtcata tacagggaaa    662

 acatggcatg gtgtggaggg catgggcttg aaattacgga acagagaggt ggtcttctct    722

 ctctcactct actggaggaa gcatctcccc tttttaacat gagttttctt actgggaata    782

 acaaagcgaa ct                                                        794




      <210> 330
      <211> 405
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (239)..(385)

      <400> 330
 ctccggtaat cgagggtcga cccacgcgtc cgcttatttg tctgtgtgtc cttggacaag     60

 ctacttagct tctatgctaa gtttcctcat acttacagag ttggtttgag tgttaaatag    120

 gatcatgcct ataaaacact taggtcatca ccttgcatag agcatatgtc agtgaaaatt    180

 aacttaaatt gttattttta ttattagcag atttttttca gcctgcacgt gtacatcc      238                                                                 
 atg cat tgc aca ttc ctt tct gtt ctt gcc ctc cct gtc att gtg agg      286
 Met His Cys Thr Phe Leu Ser Val Leu Ala Leu Pro Val Ile Val Arg
   1               5                  10                  15

 ata ctg aaa agt tgg tct tcc tgt ctc tgg gaa ggc aat tta gtc cat      334
 Ile Leu Lys Ser Trp Ser Ser Cys Leu Trp Glu Gly Asn Leu Val His
              20                  25                  30

 gta aaa tgt ctc aaa ttc cct gtt ccc tgt cct acc aat aac gta gaa      382
 Val Lys Cys Leu Lys Phe Pro Val Pro Cys Pro Thr Asn Asn Val Glu
          35                  40                  45

 taa aaacataacc cactgaaaaa                                            405
 






      <210> 331
      <211> 673
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (207)..(344)

      <400> 331
 cttatttgtc tgtgtgtcct tggacaagct acttagcttc tatgctaagt ttcctcatac     60

 ttacagagtt ggtttgagtg ttaaatagga tcatgcctat aaaacactta ggtcatcacc    120

 ttgcatagag catatgtcag tgaaaattaa cttaaattgt tatttttatt attagcagat    180

 ttttttcagc ctgcacgtgt acatcc atg cat tgc aca ttc ctt tct gtt ctt     233
                              Met His Cys Thr Phe Leu Ser Val Leu
                                1               5

 gcc ctc cct gtc att gtg agg ata ctg aaa agt tgg tct tcc tgt ctc      281
 Ala Leu Pro Val Ile Val Arg Ile Leu Lys Ser Trp Ser Ser Cys Leu
  10                  15                  20                  25

 tgg gaa ggc aat tta gtc cat gta aaa tgt ctc aaa ttc cct gtc ctg      329
 Trp Glu Gly Asn Leu Val His Val Lys Cys Leu Lys Phe Pro Val Leu
                  30                  35                  40

 tca cat ggc tca tga actgcctctg gcttctgaag gagcctgaag gagttgtcaa      384
 Ser His Gly Ser 
              45

 acctgccgca gagtgctgac gatatgtcag tgtaggttca tccattgtaa caaatgttct    444

 aatctggtgt gggattttga tagtggggga gtctggaggt gggtagcggg tatgtggaaa    504

 atctctgtac tttctgctca attttgctgt gaccctaatg ctgctctaaa aataacatct    564

 tttgggaaaa aaatatattt acacacatac aaaataatgt gagcagtaca tgccaggcac    624

 tgaattatga ttccattgaa atagtttgaa aatgtggaaa tcattaaaa                673




      <210> 332
      <211> 708
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (145)..(288)

      <400> 332
 ccccaaatca ctacttgtgg tgctttcaca gtcactcacc gacatggaca gagcggtggg     60

 atttttgagt tgaccagtgc acacgttccc agctgaggct gagcgaagca gtgctctgct    120

 ttcttgtttc agctcttata ttat   atg cat gtc ctt ttc aca ctg tat tta     171
                              Met His Val Leu Phe Thr Leu Tyr Leu
                                1               5

 gtg cca tgt tgt ttg cat ttt gag ctt ttt att ggt gat ctt gct gtt      219
 Val Pro Cys Cys Leu His Phe Glu Leu Phe Ile Gly Asp Leu Ala Val
  10                  15                  20                  25

 aaa aat ggc acc aag cat agc gct gaa gtg cta tct aga gtc cct aag      267
 Lys Asn Gly Thr Lys His Ser Ala Glu Val Leu Ser Arg Val Pro Lys
                  30                  35                  40

 cac aag aag gct gtg agg tga ct taaggagaaa atatgtgtca ggtaagttta      320
 His Lys Lys Ala Val Arg 
              45

 caccagcatg agtcatagta ctgttggccc tgagttcaag gaatcaacaa tatgtattta    380

 cagaaggtat ggttaaacag aaacacacct acaacaaggt catgtattaa tccattgagg    440

 aaaatgttgt ggccaaaggc ttgcaggaac ctaaccttga atttccccta cgagcaatgg    500

 ttcaggatac tctaacttgg tttcgaagaa acttagtact atgaatagca tgtattcgta    560

 gtaggataaa taggcctatt tgaaggagaa ggagaattcc actgacccct tttacatttt    620

 tttttttttg tttctacgga cccatcactg aaaggttggc gcggggactt aatcggcagt    680

 taggccttta agagggacaa ggggcctt                                       708




      <210> 333
      <211> 708
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (298)..(486)

      <400> 333
 ttgaaaaaac atttgtgggc ttgtggggcc gccctcaaaa gatgaattac cccccagggg     60

 tgataataag tgtctgagaa aaaaaaaatt accccacggg gaaccacatt ccaccatgat    120

 ttttctaaaa cccccgtttg tggaatccct aaaagattcc cactttcatg cgcaccccat    180

 aaatcctggc ttgggtcaaa ttccctccag tatgtaagcc ctggatctgg aaggtaatgg    240

 cacagggatc ccctgtctca cctccaccca agacatgcat tctgtttgta agtccct       297                                                                 
 atg aag tgt ttt ttg ttt gtt tgt ttg ttt gtt tgt ttt tcc gag aaa      345
 Met Lys Cys Phe Leu Phe Val Cys Leu Phe Val Cys Phe Ser Glu Lys
   1               5                  10                  15

 ctg gat ttg gga gcc tct ttc ttc agc ctc tca gct ccc ttg gcc ttt      393
 Leu Asp Leu Gly Ala Ser Phe Phe Ser Leu Ser Ala Pro Leu Ala Phe
              20                  25                  30

 ggg gtt agg ttt tca tgg tcc tgc tta cca cgg aac agt gct gta cat      441
 Gly Val Arg Phe Ser Trp Ser Cys Leu Pro Arg Asn Ser Ala Val His
          35                  40                  45

 gtt ctg gtc atg aga gac acg aaa gcg aac atg cca tgt tcc tga tct      489
 Val Leu Val Met Arg Asp Thr Lys Ala Asn Met Pro Cys Ser 
      50                  55                  60

 cactgagcct gaactagtgg ggaagacaga tgtcattcaa cagtcaatgg caaaagaacg    549

 tgacatgtgc caggaagagt cagtgtttca taatcctttg taagagaatt ttaagtgtgt    609

 ctgggatttg tctctggtgt tgtattcact ttacctgata caaattcatc ctcatgttaa    669

 aaagcaggaa actgaggcac cagggataaa gtaatttgt                           708




      <210> 334
      <211> 387
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (122)..(337)

      <400> 334
 ttcaataccc tgtctctaaa aaaaattaac aataacaaat aaaattaaat tgtcctgtta     60

 ttattccacg taaggaggat gtccattaga acaagggaga ctagtccagc tccttatact    120

 c    atg gga agg ctg ttt cca tta gta ttg ctt ttg ttc cca gta act     166
      Met Gly Arg Leu Phe Pro Leu Val Leu Leu Leu Phe Pro Val Thr
        1               5                  10                  15

 aac tct gtt tca cct act gca ctg ttg gtg ctg gtc acc aca ggt ggc      214
 Asn Ser Val Ser Pro Thr Ala Leu Leu Val Leu Val Thr Thr Gly Gly
                  20                  25                  30

 tct gga cct gcc acc atg gtc ctc ctg ccc gca cca gtg atg ggc aga      262
 Ser Gly Pro Ala Thr Met Val Leu Leu Pro Ala Pro Val Met Gly Arg
              35                  40                  45

 att cca aac cat tgc ctc tct aag tca tct cgc cag agc ccc agt ccc      310
 Ile Pro Asn His Cys Leu Ser Lys Ser Ser Arg Gln Ser Pro Ser Pro
          50                  55                  60

 aga tgt gac aaa cct gaa gtc cca tga gtgtg cctacttgct ggcagacatc      362
 Arg Cys Asp Lys Pro Glu Val Pro 
      65                  70

 aagaaaaaca caaaagtggg cattt                                          387




      <210> 335
      <211> 1503
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (1231)..(1422)

      <400> 335
 attggcacga ggcacaatga aaaaaaaaat cttttctaag gtatttttct ggctaatttt     60

 tatttgaaga aagctatagc atttagcgaa atttgactga agtaatgttc tgagtttgca    120

 ttagtgggat tggtgatgtt ctcagaagaa aattggaaac acttgtgatg aattgtcttt    180

 cagatcactt agattttctg atgtaagagg acagctattt ggttctgata caggcctgct    240

 tacttgggat gtagggttag taaatggggt ttctgcttta aaggactgac ttgctatcgc    300

 acaaaagagg cagacttgta aacacaatgg gctttggagt ttggtctgat tgggtttggt    360

 ttagtattcc tatgagcgta aatggtaaaa ttcttctgat acccactctt tagactgtgc    420

 cttctgctct gttctttgtt ttatgtttaa ctgctgtttc taattgcagg tgtattacag    480

 ataccaataa gagtaaagaa aatatatttc attatagaaa agaaaaaatt aaaagcttct    540

 tgcttttcag tgcctgatag agtgaaaaca caaagttgca ctttaataat ttcaataaaa    600

 gctaatctgt gtcagcctcc ctctgcttca gagagtcagg tgagcatcca taacctaaca    660

 ggcagagccc tagcgatgtg gatcaagttt cctgagcccg ggggcggtgg agcctcatga    720

 tctcttatct tttgaggctg aggcaggtca catgcaacaa attgtgaccc tgctccccac    780

 aagtcatgca aaggttttga agagctttta ccgtggggca gatgaacttg tgtcaaccat    840

 gcacaccctg tgagaaccaa gtacctgtgt ttctaaggcg ggcactcaag gtgaggggtg    900

 cattctggcc aaagaaacaa aagctgtggt ttcaggacca tgccgtgtgt agctgatctg    960

 tacgggacgt gtatgtaagg aagagcaatc atgatagata agaacagtgt gtgaagcagc   1020

 cctcacacta gagtgtttgg tcatctctta taatgtaagg gaaggtactt taaaattctg   1080

 ggaagatgcg atgaactcat gtcccagtca gaaaataatc caatgaaata agcattggtt   1140

 gccaggccac agttaggaat tgtattgtga tacatctaga ggccaagaga gcaggagaga   1200

 gctaccaact tacactgtgg tttaagctaa     atg acc gca cag cat cat agc    1251
                                      Met Thr Ala Gln His His Ser
                                        1               5

 att gca gtg ttg tta cta aat ctg gaa gtg acc tgt gaa tgt atg gaa     1299
 Ile Ala Val Leu Leu Leu Asn Leu Glu Val Thr Cys Glu Cys Met Glu
          10                  15                  20

 tac aat aaa gtc ttt tat tct ggt tca ttt gct agt act tcc ttt ttg     1347
 Tyr Asn Lys Val Phe Tyr Ser Gly Ser Phe Ala Ser Thr Ser Phe Leu
      25                  30                  35

 att gga tac tgt agt tct tcc tct gga ttt tat ttt gtt cag cgt caa     1395
 Ile Gly Tyr Cys Ser Ser Ser Ser Gly Phe Tyr Phe Val Gln Arg Gln
  40                  45                  50                  55

 ggc cct aat ttt gca aat gta gtc taa accac attacgtgga ctagaggata     1447
 Gly Pro Asn Phe Ala Asn Val Val 
                  60

 ctctgaatta gcaagttttt tgtttgctga ataaaactat tccatcttaa caaaaa       1503




      <210> 336
      <211> 1892
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (306)..(1838)

      <400> 336
 ggggataaca gcagtatcgg ccttgagtaa aatcactctt cattcttcta ctgccttcca     60

 aaatgttatt gaaaaggtgg gactgaactc agtaataaac tccctggcct ctgccatctg    120

 caaagttcag cagtacatgt tgaccttatt cgctgccatg ttggcctgtg ggattcatct    180

 tcaaagacta atccaagaaa agggttttgt ctccacaatt atccgtttac ttgacagccc    240

 ctcaacatgc attagagcaa aagccttcct gggttcttct atatattttg atttataacc    300

 gtgag    atg ttg ctg ctc agt tgc caa gca aga ctg gtg atg tac atc     347
          Met Leu Leu Leu Ser Cys Gln Ala Arg Leu Val Met Tyr Ile
            1               5                  10

 gag aga gac agc aga aag acc act cca ggc aag gag cag caa agt ggc      395
 Glu Arg Asp Ser Arg Lys Thr Thr Pro Gly Lys Glu Gln Gln Ser Gly
  15                  20                  25                  30

 aat gaa tac ctg tcc aaa tgc ctg gat ctt ctc atc tgt cac att gtg      443
 Asn Glu Tyr Leu Ser Lys Cys Leu Asp Leu Leu Ile Cys His Ile Val
                  35                  40                  45

 cag gag ctg cca cga atc ctg ggt gac att ctt aac tcc ttg gct aat      491
 Gln Glu Leu Pro Arg Ile Leu Gly Asp Ile Leu Asn Ser Leu Ala Asn
              50                  55                  60

 gtt tct gga cgt aaa cac cca tca aca gtt caa gtg aaa cag ctg aag      539
 Val Ser Gly Arg Lys His Pro Ser Thr Val Gln Val Lys Gln Leu Lys
          65                  70                  75

 ttg tgt ctc ccc ctg atg cct gta gtg ctt cac ctc gta act tca cag      587
 Leu Cys Leu Pro Leu Met Pro Val Val Leu His Leu Val Thr Ser Gln
      80                  85                  90

 gta ttt cga cct caa gtt gtg aca gaa gag ttt ctt ttc agc tat gga      635
 Val Phe Arg Pro Gln Val Val Thr Glu Glu Phe Leu Phe Ser Tyr Gly
  95                 100                 105                 110

 act att ctt agt cat att aaa tct gta gac tca gga gaa acg aac ata      683
 Thr Ile Leu Ser His Ile Lys Ser Val Asp Ser Gly Glu Thr Asn Ile
                 115                 120                 125

 gat gga gcc ata gga ctg aca gca tca gaa gaa ttt atc aag atc aca      731
 Asp Gly Ala Ile Gly Leu Thr Ala Ser Glu Glu Phe Ile Lys Ile Thr
             130                 135                 140

 ttg tca gct ttt gaa gca ata ata cag tat cct att tta ttg aaa gac      779
 Leu Ser Ala Phe Glu Ala Ile Ile Gln Tyr Pro Ile Leu Leu Lys Asp
         145                 150                 155

 tat cgc tcc acg gtt gtt gac tat ata ctg cca ccc ttg gtg tcc ttg      827
 Tyr Arg Ser Thr Val Val Asp Tyr Ile Leu Pro Pro Leu Val Ser Leu
     160                 165                 170

 gtt caa agc caa aat gtg gag tgg aga ctc ttt agc ttg cgg ttg ctc      875
 Val Gln Ser Gln Asn Val Glu Trp Arg Leu Phe Ser Leu Arg Leu Leu
 175                 180                 185                 190

 tca gaa acc aca tct cta ctc gtg aac cag gag ttt ggg gat ggc aag      923
 Ser Glu Thr Thr Ser Leu Leu Val Asn Gln Glu Phe Gly Asp Gly Lys
                 195                 200                 205

 gag aag gcc agt gtt gat tct gac agc aat ctt ctg gct ctc att cga      971
 Glu Lys Ala Ser Val Asp Ser Asp Ser Asn Leu Leu Ala Leu Ile Arg
             210                 215                 220

 gat gtc tta ctt ccc cag tat gag cac att ctt tta gaa cct gac cca     1019
 Asp Val Leu Leu Pro Gln Tyr Glu His Ile Leu Leu Glu Pro Asp Pro
         225                 230                 235

 gta cca gca tat gct ctg aaa ctg cta gtc gcg atg act gaa cac aac     1067
 Val Pro Ala Tyr Ala Leu Lys Leu Leu Val Ala Met Thr Glu His Asn
     240                 245                 250

 cca act ttc aca aga ctt gtg gaa gaa agc aaa ctg atc cca ctc att     1115
 Pro Thr Phe Thr Arg Leu Val Glu Glu Ser Lys Leu Ile Pro Leu Ile
 255                 260                 265                 270

 ttt gaa gta act ctg gaa cat cag gag agc att ctg ggt aat acc atg     1163
 Phe Glu Val Thr Leu Glu His Gln Glu Ser Ile Leu Gly Asn Thr Met
                 275                 280                 285

 caa agt gtg att gca tta ctc agc aat cta gtt gcc tgc aaa gat tcg     1211
 Gln Ser Val Ile Ala Leu Leu Ser Asn Leu Val Ala Cys Lys Asp Ser
             290                 295                 300

 aat atg gaa cta ctt tat gaa caa gga ctt gtc agt cac atc tgt aac     1259
 Asn Met Glu Leu Leu Tyr Glu Gln Gly Leu Val Ser His Ile Cys Asn
         305                 310                 315

 ctg ctc act gaa act gcc aca ctg tgc ttg gat gtg gac aat aaa aac     1307
 Leu Leu Thr Glu Thr Ala Thr Leu Cys Leu Asp Val Asp Asn Lys Asn
     320                 325                 330

 aac aat gag atg gca gct cca ctg ctc ttt tcc ctg ctt gat att ttg     1355
 Asn Asn Glu Met Ala Ala Pro Leu Leu Phe Ser Leu Leu Asp Ile Leu
 335                 340                 345                 350

 cac agc atg ctg acc tat acc tcc ggt att gta cgg ctg gct ttg cag     1403
 His Ser Met Leu Thr Tyr Thr Ser Gly Ile Val Arg Leu Ala Leu Gln
                 355                 360                 365

 gcc cag aag tct ggc tca gga gag gac cct cag gct gca gaa gac ctg     1451
 Ala Gln Lys Ser Gly Ser Gly Glu Asp Pro Gln Ala Ala Glu Asp Leu
             370                 375                 380

 ctg ctg ctc aac aga cct ctg aca gac ctg att agc ctg ctc att cca     1499
 Leu Leu Leu Asn Arg Pro Leu Thr Asp Leu Ile Ser Leu Leu Ile Pro
         385                 390                 395

 ctg ctt cct aat gaa gat cct gag att ttt gat gtt tca tcc aag tgc     1547
 Leu Leu Pro Asn Glu Asp Pro Glu Ile Phe Asp Val Ser Ser Lys Cys
     400                 405                 410

 ctg tct ata ctg gtt cag ctg tat gga ggg gaa aac ccg gac agc ctc     1595
 Leu Ser Ile Leu Val Gln Leu Tyr Gly Gly Glu Asn Pro Asp Ser Leu
 415                 420                 425                 430

 tct cct gaa aat gtg gaa att ttt gct cat tta ctg aca tcc aag gag     1643
 Ser Pro Glu Asn Val Glu Ile Phe Ala His Leu Leu Thr Ser Lys Glu
                 435                 440                 445

 gac cca aag gag cag aag ctt ctg tta agg att ctc aga aga atg atc     1691
 Asp Pro Lys Glu Gln Lys Leu Leu Leu Arg Ile Leu Arg Arg Met Ile
             450                 455                 460

 acc tcc aat gag aag cac ttg gag agc ctc aag aat gca ggc agc ctc     1739
 Thr Ser Asn Glu Lys His Leu Glu Ser Leu Lys Asn Ala Gly Ser Leu
         465                 470                 475

 ctg cgg gct ctg gag cgg ctg gcc cct ggg agt ggt tca ttt gcc gac     1787
 Leu Arg Ala Leu Glu Arg Leu Ala Pro Gly Ser Gly Ser Phe Ala Asp
     480                 485                 490

 agt gcg gtg gct ccc ttg gcc ctg gaa atc ctc caa gcc gtt ggg cac     1835
 Ser Ala Val Ala Pro Leu Ala Leu Glu Ile Leu Gln Ala Val Gly His
 495                 500                 505                 510

 tag gcaa gaaggtgctt agcacaagcc cgccctgtgg ccccagccct cggatgcata     1892
 






      <210> 337
      <211> 731
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (312)..(599)

      <400> 337
 ccctggtcta aatgaaatcg aagagttctt attaattatt cataatgcca tgaatatgtt     60

 accttatttt ttataattgc cagtctgtat aattaacctt tcatttggtt aaagtactta    120

 acattaagta gagctataat tacaactgtt tttaaaagta tatggaagaa tgtttaaatg    180

 tttaattaga accacttttt ttagcttcat aaagaatttt ttttacttgt caacaaggat    240

 ctttaattat ttaaaccaaa agagcagaac agaccagaaa agaaaaacaa ctagtcaagc    300

 tgggaactgc a atg gtg gcg tcg ttc cgt gag tct cgg gtt ttg ctt ctt     350
              Met Val Ala Ser Phe Arg Glu Ser Arg Val Leu Leu Leu
                1               5                  10

 ggg ttt gtg gtc aga gtc ctt acc ttt gat ttc cta aca cag gtt gtt      398
 Gly Phe Val Val Arg Val Leu Thr Phe Asp Phe Leu Thr Gln Val Val
      15                  20                  25

 aga gtt gga agt gag tgt gga gat gag tta gtc cga ctt tat tct ttc      446
 Arg Val Gly Ser Glu Cys Gly Asp Glu Leu Val Arg Leu Tyr Ser Phe
  30                  35                  40                  45

 acg gat gag aaa gcg aat tat ctt cag caa ggt ggg tgc agg tgt ggc      494
 Thr Asp Glu Lys Ala Asn Tyr Leu Gln Gln Gly Gly Cys Arg Cys Gly
                  50                  55                  60

 ccc cgg ggg aca ctg tgg gga ata ggc cgc cct cgt ggg gag cca agt      542
 Pro Arg Gly Thr Leu Trp Gly Ile Gly Arg Pro Arg Gly Glu Pro Ser
              65                  70                  75

 tcg tcg tct ccg gga cag agc cca gga cac ttc cac ggc tgg ctg gcc      590
 Ser Ser Ser Pro Gly Gln Ser Pro Gly His Phe His Gly Trp Leu Ala
          80                  85                  90

 tct tcc tag aacccca cacattgcaa aggatggagt ccagatctat actgtaaaga      646
 Ser Ser 
      95

 aatgagggca gtacagaaag caccacattc tcggctgagt ggctctgggc accccaacgt    706

 tgggacacct cagcatcatg tatgg                                          731




      <210> 338
      <211> 1095
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (134)..(280)

      <220>
      <221> misc_feature
      <222> (1)...(1095)
      <223> n = a,t,c or g

      <400> 338
 gaattcccgg gtcgacgatt tcgttggagg cctgacccta catgactaat atttctgtcc     60

 tcatttcctt atgggcctcc ctgtaatgtt atgtttccct ctaacatgag tatgtgctgc    120

 ttactggaag cac   atg agt gaa ttt ctt tgt ttc ttc acc caa aga gcc     169
                  Met Ser Glu Phe Leu Cys Phe Phe Thr Gln Arg Ala
                    1               5                  10

 ata gta aca act ttt tct cta tcc act acg gag ggt aac agc tgt gcc      217
 Ile Val Thr Thr Phe Ser Leu Ser Thr Thr Glu Gly Asn Ser Cys Ala
          15                  20                  25

 aca tgg ctc tgt gtc cct ttc cct ggg tgc tca gtt ttg tgg tca gta      265
 Thr Trp Leu Cys Val Pro Phe Pro Gly Cys Ser Val Leu Trp Ser Val
      30                  35                  40

 ctt gac cgc aaa taa atgaacctct tacccaaggt tgagatggag aatgaggagg      320
 Leu Asp Arg Lys 
  45

 gataaagagc tggcaaaata ttgtgtagaa acaggaattg atgagatcag aatagatttt    380

 gatctttcac agagagtaaa acatttcatc ctctgtttct aaggtggtgt ccttaaggtt    440

 gtgatgcaga attcagaaga gtgtttgatg gaccatgttt gtgttgggct tgatttcata    500

 tttagtgaga taaatggcta cataaaaaca ttgacttaaa actgacgtga gcagatggta    560

 gagaatattc tattatttca aattttaaaa tagtgaaaca gattaataag gtctaggttt    620

 tcttccctga gaattttaac aaacaagtat cagtgacaaa cagaatgtta gttgtagtga    680

 aagaggtata tgactgtcct atctaagaaa cagaggatgt ctcagctgtt ttggcctata    740

 tcaatgaaaa ctgagatcaa ggtgatgata atgagttgat agtttttttg ttagatagct    800

 aatcattact tttgtgacct ggagctatcc cagtttaact taatttgagc cataattttt    860

 ctagggactt gctgcttgca tgtttagcta cacggagttt tgaacttgat ttacaaatga    920

 aattatagtg aaggagggaa gagaagggaa aggccattgt tataaaaaat gagaaaatgt    980

 ctatgttctt tttatgcaaa ttcttcaata gcatttttat taattttcta gggaccgtgt   1040

 atgcgtccgc tctagaggat ccnagcttgc gtcgcgatcg taccgtctat ccaat        1095




      <210> 339
      <211> 1139
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (386)..(526)

      <400> 339
 tcgactcact atagggaatt tggcctcgag cagaaattcg gcacgaggca gaaatctgct     60

 tctgctgaag gggtcggtgc tgttcgtttt ctgaattttc tgacaagact ggttaggtcc    120

 tccaagggga tctgctccgg tcatgtcctc aggagctagt gatgcccgga ctgatgccat    180

 cactagtcca gcagtggtac tcagtctcag ggatgcagtg ctgccgaggg aggcctcgca    240

 gcagggagtg caggaaccag cacaggagat tagaaccaag ttttgagcag cagcaagacg    300

 ctggaaataa agtgcatcct agtgtctaat tcaaacagat catcacggtg tggtttcaac    360

 agaacatttt cccttccttt cttgc  atg gga ttc tta tgt gaa ata gga gca     412
                              Met Gly Phe Leu Cys Glu Ile Gly Ala
                                1               5

 att cct aca atg gtg ctg gcc ctc tgg ggg ttt ctt agg gcc agc tct      460
 Ile Pro Thr Met Val Leu Ala Leu Trp Gly Phe Leu Arg Ala Ser Ser
  10                  15                  20                  25

 gcc tct ccg cct tct ctg aac agg ctg cct ggg cag ggc tct gct ttc      508
 Ala Ser Pro Pro Ser Leu Asn Arg Leu Pro Gly Gln Gly Ser Ala Phe
                  30                  35                  40

 tca ttt cag atc tgc taa cttcac atgtcaccta ctgccgagtc actttcctga      562
 Ser Phe Gln Ile Cys 
              45

 tggactcatg ggacttttct gcatgctatt tctacaaatt cattctctct ccacgtagga    622

 caaaaaacat gcttggcatg tgctttgtgg agtgcggggg tgctggggta gggaggctgg    682

 ttagtcagaa gcagctgttg agtgagcttg aacattcctg gagacttgag ttagctccat    742

 gattttaccc atctgtcaca ccctcctggg catgtgacct ccagattctg agttgaccct    802

 catgtgggag agagatctgt gtttgagtga agcagccctg gaaactacct ccttcctgat    862

 ggaaaccctt gatcttctcg ggattggttt ctagcctcat ttgccttcat attccctctg    922

 tgctctttac caccacccag ctctgaatac ggggacaggg aggaggtggg gcagggagat    982

 tcaggatggc tgacccctca tcttcctcat ccatcattct ctggttctca tagaattagg   1042

 gctgcactgg gccttggggg attcagccca ttcttttact atagagtagc acatttcctc   1102

 atcagatttt taaagtgatt gacttcacca ttgaggt                            1139




      <210> 340
      <211> 722
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (128)..(301)

      <400> 340
 gcacgagatt ttgttgtaat ttatcttctc ttttctgcta aaaataagtc tatgagtcaa     60

 catttcacat aactcatatt gttttctctc tgaagatttt aaaagacatc aaatttcatt    120

 tttattg  atg ttt att ttt aaa acg aaa gga atc ctt ttg ccc tgt caa     169
          Met Phe Ile Phe Lys Thr Lys Gly Ile Leu Leu Pro Cys Gln
            1               5                  10

 aag atg cta caa ata gta ttc ttt ttt ctt cct aaa aat act ttg tcc      217
 Lys Met Leu Gln Ile Val Phe Phe Phe Leu Pro Lys Asn Thr Leu Ser
  15                  20                  25                  30

 tca atg ttt tat ttt tca gat tgc ata gga gta cat aag tat atg cat      265
 Ser Met Phe Tyr Phe Ser Asp Cys Ile Gly Val His Lys Tyr Met His
                  35                  40                  45

 att tta att tat ata cat aca tat gta tca ctg taa cttg gaaattaaga      315
 Ile Leu Ile Tyr Ile His Thr Tyr Val Ser Leu 
              50                  55

 atgtcataga agaatagtta aaggcaatga gaaagtgttg atgaaaaagg aggagcctat    375

 ggggaaacaa aataattata tgcaaatacc cgaaggtaag aaatatggaa aaggcaattg    435

 tcttgctcta ggttgtcaca gacaagagaa ttgtactaat tgggtaagaa ataaattgca    495

 tgtgagtttt ttaaaaatat ttctattaaa aagttaaaga tcattttttc tatcatatca    555

 ttgacctcct ttttacaata gctatggatt attatttcac ctctattttc aagaaaaatt    615

 agtaaaagtt aaagattata tcaacagctt catggaggta gctgattttg cttatataca    675

 cccttagtac gttactagta ttaataaatg gcctcagaac aacgaca                  722




      <210> 341
      <211> 679
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (68)..(238)

      <400> 341
 tcgctgcagg aattcggcac gagcaccttc ttactttatg aaagcgctgt gttatgtcct     60

 ttctaag  atg cac ctt ttt ttt cat act tta aca tct cta aga ttg gga     109
          Met His Leu Phe Phe His Thr Leu Thr Ser Leu Arg Leu Gly
            1               5                  10

 tgc atc ata cag tct ctg ttg gca agg ggg gcc tca tgc tgt tac tgc      157
 Cys Ile Ile Gln Ser Leu Leu Ala Arg Gly Ala Ser Cys Cys Tyr Cys
  15                  20                  25                  30

 cat cac atg aac atc aga att tgc gag tgg atg tca gca gct cag aag      205
 His His Met Asn Ile Arg Ile Cys Glu Trp Met Ser Ala Ala Gln Lys
                  35                  40                  45

 gaa atc cca gag ata gta gta gag cat cct tga tgctggag aagcccaggc      256
 Glu Ile Pro Glu Ile Val Val Glu His Pro 
              50                  55

 tgtgtggaat agcacagcat taaaaactcc atgatagaga gattaagaga cattggactc    316

 gaaatgtgaa aaggaatacc ttaaacaatt tatttcaatt atattttcct ttttaaaaat    376

 ttacaaaagt gatagatgct tttttaaaat ctggatctaa tatattctaa aagagttctt    436

 tcagtaagta caaaaaaacc cctgaatgac aggaactcat cataagggta gcagttctga    496

 cactacttta tatgtatccc aggaatgaac aaataagcaa aaatattatg gatgagagcc    556

 aggtttctca ccactggaga aaaacaattg caatcaaacg ggggaagcta gaatgcactc    616

 tgtggtgttg aattagagtt aaagggatca gtataaattc cagattccat atatatgata    676

 tat                                                                  679




      <210> 342
      <211> 562
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (384)..(515)

      <400> 342
 gactagaagc tcttgggagc atgtggacag ttgtggctgc tcctgagctg acactaatgc     60

 tcatgactcc tctgtgggag aagtaggtgg tttcctagag gaagaagttg gggtaatgaa    120

 gccacagaga ttggctgata catttgctag gcacgacttc tggtcattta gaaagctatt    180

 ttgtggcttc atcaataagg tattccccag ctgtgttact ccttcgcatg ttatctcttt    240

 ccctggaatt gaaggcttcc tggtctgagg caaggacaat tattccctca ctgtcaaccc    300

 tgatctctgg ctgcagtaat gagtagagga aatgaagaaa taagaatgga agcataatca    360

 tttgtccgag gtcacagagg gag    atg att aca cag ctt gga gaa act ctc     410
                              Met Ile Thr Gln Leu Gly Glu Thr Leu
                                1               5

 ctc ctt caa tac ctg act act tgc acc atc cag cag ata tcc tct act      458
 Leu Leu Gln Tyr Leu Thr Thr Cys Thr Ile Gln Gln Ile Ser Ser Thr
  10                  15                  20                  25

 acc aag tct caa cag atg gtt cag ctg gtc ttt aat gaa caa aag gca      506
 Thr Lys Ser Gln Gln Met Val Gln Leu Val Phe Asn Glu Gln Lys Ala
                  30                  35                  40

 ttt gtg taa tggactc ttattgctca agaagaattt cttccttcct gaaacatgag      562
 Phe Val 






      <210> 343
      <211> 1268
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (69)..(242)

      <400> 343
 aattcggcac gagcagctta cttgaaggtc cccccttggg gctttctgga agcctccaga     60

 ggcctccc atg tgt ttg aga aga act ctt ctt tgg cac ctt cac atc gca     110
          Met Cys Leu Arg Arg Thr Leu Leu Trp His Leu His Ile Ala
            1               5                  10

 ccc ctt gtt aat att ctc tct gac tac aag cca ctg gga agg tgg aac      158
 Pro Leu Val Asn Ile Leu Ser Asp Tyr Lys Pro Leu Gly Arg Trp Asn
  15                  20                  25                  30

 cat gcc ccg gcc ctt aca gct gga gcc ctc cac aag acc acc att ctt      206
 His Ala Pro Ala Leu Thr Ala Gly Ala Leu His Lys Thr Thr Ile Leu
                  35                  40                  45

 ctg ccc cag ggt cat ccc aaa gct gca aac cct taa tcac tgcactgtct      256
 Leu Pro Gln Gly His Pro Lys Ala Ala Asn Pro 
              50                  55

 acagtgtacc ataaacatgc tgtttcctag agaagggaag agaaggagcc tcaccttgac    316

 tccatgctaa ccttgattcc taggccccaa agcagcactg cttgggtcca ctatttaata    376

 gcttcttcag cttcccaata aggctcagag ctgaccctgg gcccaggcag gagagcaaac    436

 cttcctatcc cttctgggta tcctttgctg tgtaacaaac tatcctaaaa cttaaaggct    496

 taaaataaca accatgtgtt atttttcata attctgtggg ttgactgggc agctctgtaa    556

 gttctgctca gggtctctta tgaggcttta gtcgcatggt ggctggagct cttggctggg    616

 gctaaaacat cgaagatggc tttactcatg tgttctgtgc cttcacaggg tcagttggaa    676

 ggctggcacc gctgtctctc catgtggttt ttccacttag ctagcttaga cttcttttca    736

 tgatagttgg atctcaagag tgttccaata gggaggaagc ataggttact agttctctta    796

 gggtgtgggc ccagagctag catctgctgc attcaattag ttaaagtagt cacagggcca    856

 gccaggattc aaggggaaag aaaataagcc ctagctcatg atgaggttag tgacaaagaa    916

 tttgcagcca tctttaaaat ccactgccat tccccctagt ttttgaggct gttcctaagg    976

 aaacagtcct ccttgcggct ttcttctctc cacgtaaatc agctgagcaa aggagcagct   1036

 aaggagctga tgaccttaca taagcgatct cagtttaggc tcaatgggaa ccactccact   1096

 gatctcttat gagtcttact gcaattcagc caggtaggtt ttcttatccc ccattgtgca   1156

 ggtgaagaac ctaaaattca gagagcttaa gtgatcgatg caaggtttca gctagtaaaa   1216

 tggtcaatcc aggattcaaa ctcaggtcag cataactccc gggaattccg gg           1268




      <210> 344
      <211> 853
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (324)..(488)

      <400> 344
 tgtcgttgtt ctggccccgg gctgcaggaa ttcggcacga gaaatgcagt ggcctgcttg     60

 gaccaagcag atacttaagt ggataaacag tgacagatgt aagtgcatag gactacctac    120

 actatgtggc tggtaggaac actaataaac tatctgaaga ggacatctgc ttctcagctc    180

 ctcatgactt ctgtcattta gaaatgtggg caagtatttc ctgacttgat atgttattaa    240

 gaaaaactgg aaatatagat tttttattaa ttttaaattt tctgaaatat gcggcaacag    300

 acatggtata aatctagctt gga    atg tta gtt ttc aat ctt tct ctt gtt     350
                              Met Leu Val Phe Asn Leu Ser Leu Val
                                1               5

 ctc agt cat agt gtc cta gaa ttt gta atg ttc ctg tat agt ctt gat      398
 Leu Ser His Ser Val Leu Glu Phe Val Met Phe Leu Tyr Ser Leu Asp
  10                  15                  20                  25

 agc tct cat gtc tgc cct ctg gtt gtc cct gtc act ctg gat tta atc      446
 Ser Ser His Val Cys Pro Leu Val Val Pro Val Thr Leu Asp Leu Ile
                  30                  35                  40

 tac ttg gtt tat cta cct tgt cag tct tac ata ttg atc tga atgttat      495
 Tyr Leu Val Tyr Leu Pro Cys Gln Ser Tyr Ile Leu Ile 
              45                  50

 ttattttttt cctgagtcta cacaatgcct ttcctagaca tttacttctt agttttcatt    555

 ctattgcatt gttacagttt aaactatact tttttaaagc tcaatttcca tctttttata    615

 ataatcttgc taactcagag gcaaacaagt tacaaaagat gtatttttta gacaacactt    675

 aaaaaataca gaatttgacc atttcttgag atttaatctt acattttata atggggtcac    735

 tgaaatctga attgacatgt ctggcctact tttaattaag ccctctttta atataacctt    795

 tattaagagg aacttgattt ccattgcgag aaaaatgagt ggcttcctgt cgacgaat      853




      <210> 345
      <211> 792
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (216)..(368)

      <400> 345
 actgacttgt ggccttcact gtggagcagt tagtatcttt atgtctttgc tggaactgtt     60

 aattttttcc agagaaaact ctagtctcct gactgaaggg tatgggtgta aaaccatctt    120

 catctaaaat gaagtaagca ttttagagct aaattagaga agggataatt ccccattttt    180

 cattccatgc ctcactctgt ccttctttat gccca   atg tcc ctg aat cca gaa     233
                                          Met Ser Leu Asn Pro Glu
                                            1               5

 ttt ctc tgg ctt aag tgg ttt agt ctc ttg ttg agg ggg aga agg aat      281
 Phe Leu Trp Leu Lys Trp Phe Ser Leu Leu Leu Arg Gly Arg Arg Asn
              10                  15                  20

 agt tgc ctg att gca ttg aag gga tat cat tca gta atg att ttc cat      329
 Ser Cys Leu Ile Ala Leu Lys Gly Tyr His Ser Val Met Ile Phe His
          25                  30                  35

 ctg ccc ctc atc cct tcc tct gtt acc tcc tgt cac tga gtctttagag       378
 Leu Pro Leu Ile Pro Ser Ser Val Thr Ser Cys His 
      40                  45                  50

 ttccacagag aaaatctgct tgtatctagt ctctgaaaac tttcaggttt ggccttcttt    438

 ctctctgtta aaccttgctg ccatctgctt tctgtttttg catattatga tgtctcccca    498

 ttccagtgaa catggagttt ttgtatctgt ttcttgttgg attggagtgg ttttaagata    558

 tagagggaga agacatgtct ttatgctgct gtcttcaaat ctagtagtag ctcttaatga    618

 gcacatattc tgggtgactc cgaaagaaca actcagttcg aacaattttt gtcatgtggg    678

 gtttctcagc cactgaaaca ccactagaaa gatattaata tatatacttg aggctgtcgt    738

 tgttctgaga cgaaatcgtc gacagcgaag tcgacccggg aattccggtc cggt          792




      <210> 346
      <211> 1746
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (1)..(1746)

      <400> 346
  atg cca ctg aag cat tat ctc ctt ttg ctg gtg ggc tgc caa gcc tgg      48
  Met Pro Leu Lys His Tyr Leu Leu Leu Leu Val Gly Cys Gln Ala Trp
    1               5                  10                  15

 ggt gca ggg ttg gcc tac cat ggc tgc cct agc gag tgt acc tgc tcc       96
 Gly Ala Gly Leu Ala Tyr His Gly Cys Pro Ser Glu Cys Thr Cys Ser
              20                  25                  30

 agg gcc tcc cag gtg gag tgc acc ggg gca cgc att gtg gcg gtg ccc      144
 Arg Ala Ser Gln Val Glu Cys Thr Gly Ala Arg Ile Val Ala Val Pro
          35                  40                  45

 acc cct ctg ccc tgg aac gcc atg agc ctg cag atc ctc aac acg cac      192
 Thr Pro Leu Pro Trp Asn Ala Met Ser Leu Gln Ile Leu Asn Thr His
      50                  55                  60

 atc act gaa ctc aat gag tcc ccg ttc ctc aat att tca gcc ctc atc      240
 Ile Thr Glu Leu Asn Glu Ser Pro Phe Leu Asn Ile Ser Ala Leu Ile
  65                  70                  75                  80

 gcc ctg agg att gag aag aat gag ctg tcg cgc atc acg cct ggg gcc      288
 Ala Leu Arg Ile Glu Lys Asn Glu Leu Ser Arg Ile Thr Pro Gly Ala
                  85                  90                  95

 ttc cga aac ctg ggc tcg ctg cgc tat ctc agc ctc gcc aac aac aag      336
 Phe Arg Asn Leu Gly Ser Leu Arg Tyr Leu Ser Leu Ala Asn Asn Lys
             100                 105                 110

 ctg cag gtt ctg ccc atc ggc ctc ttc cag ggc ctg gac agc ctt gag      384
 Leu Gln Val Leu Pro Ile Gly Leu Phe Gln Gly Leu Asp Ser Leu Glu
         115                 120                 125

 tct ctc ctt ctg tcc agt aac cag ctg ttg cag atc cag ccg gcc cac      432
 Ser Leu Leu Leu Ser Ser Asn Gln Leu Leu Gln Ile Gln Pro Ala His
     130                 135                 140

 ttc tcc cag tgc agc aac ctc aag gag ctg cag ttg cac ggc aac cac      480
 Phe Ser Gln Cys Ser Asn Leu Lys Glu Leu Gln Leu His Gly Asn His
 145                 150                 155                 160

 ctg gaa tac atc cct gac gga gcc ttc gac cac ctg gta gga ctc acg      528
 Leu Glu Tyr Ile Pro Asp Gly Ala Phe Asp His Leu Val Gly Leu Thr
                 165                 170                 175

 aag ctc aat ctg ggc aag aat agc ctc acc cac atc tca ccc agg gtc      576
 Lys Leu Asn Leu Gly Lys Asn Ser Leu Thr His Ile Ser Pro Arg Val
             180                 185                 190

 ttc cag cac ctg ggc aat ctc cag gtc ctc cgg ctg tat gag aac agg      624
 Phe Gln His Leu Gly Asn Leu Gln Val Leu Arg Leu Tyr Glu Asn Arg
         195                 200                 205

 ctc acg gat atc ccc atg ggc act ttt gat ggg ctt gtt aac ctg cag      672
 Leu Thr Asp Ile Pro Met Gly Thr Phe Asp Gly Leu Val Asn Leu Gln
     210                 215                 220

 gaa ctg gct cta cag cag aac cag att gga ctg ctc tcc cct ggt ctc      720
 Glu Leu Ala Leu Gln Gln Asn Gln Ile Gly Leu Leu Ser Pro Gly Leu
 225                 230                 235                 240

 ttc cac aac aac cac aac ctc cag aga ctc tac ctg tcc aac aac cac      768
 Phe His Asn Asn His Asn Leu Gln Arg Leu Tyr Leu Ser Asn Asn His
                 245                 250                 255

 atc tcc cag ctg cca ccc agc atc ttc atg cag ctg ccc cag ctc aac      816
 Ile Ser Gln Leu Pro Pro Ser Ile Phe Met Gln Leu Pro Gln Leu Asn
             260                 265                 270

 cgt ctt act ctc ttt ggg aat tcc ctg aag gag ctc tct ctg ggg atc      864
 Arg Leu Thr Leu Phe Gly Asn Ser Leu Lys Glu Leu Ser Leu Gly Ile
         275                 280                 285

 ttc ggg ccc atg ccc aac ctg cgg gag ctt tgg ctc tat gac aac cac      912
 Phe Gly Pro Met Pro Asn Leu Arg Glu Leu Trp Leu Tyr Asp Asn His
     290                 295                 300

 atc tct tct cta ccc gac aat gtc ttc agc aac ctc cgc cag ttg cag      960
 Ile Ser Ser Leu Pro Asp Asn Val Phe Ser Asn Leu Arg Gln Leu Gln
 305                 310                 315                 320

 gtc ctg att ctt agc cgc aat cag atc agc ttc atc tcc ccg ggt gcc     1008
 Val Leu Ile Leu Ser Arg Asn Gln Ile Ser Phe Ile Ser Pro Gly Ala
                 325                 330                 335

 ttc aac ggg cta acg gag ctt cgg gag ctg tcc ctc cac acc aac gca     1056
 Phe Asn Gly Leu Thr Glu Leu Arg Glu Leu Ser Leu His Thr Asn Ala
             340                 345                 350

 ctg cag gac ctg gac ggg aat gtc ttc cgc atg ttg gcc aac ctg cag     1104
 Leu Gln Asp Leu Asp Gly Asn Val Phe Arg Met Leu Ala Asn Leu Gln
         355                 360                 365

 aac atc tcc ctg cag aac aat cgc ctc aga cag ctc cca ggg aat atc     1152
 Asn Ile Ser Leu Gln Asn Asn Arg Leu Arg Gln Leu Pro Gly Asn Ile
     370                 375                 380

 ttc gcc aac gtc aat ggc ctc atg gcc atc cag ctg cag aac aac cag     1200
 Phe Ala Asn Val Asn Gly Leu Met Ala Ile Gln Leu Gln Asn Asn Gln
 385                 390                 395                 400

 ctg gag aac ttg ccc ctc ggc atc ttc gat cac ctg ggg aaa ctg tgt     1248
 Leu Glu Asn Leu Pro Leu Gly Ile Phe Asp His Leu Gly Lys Leu Cys
                 405                 410                 415

 gag ctg cgg ctg tat gac aat ccc tgg agg tgt gac tca gac atc ctt     1296
 Glu Leu Arg Leu Tyr Asp Asn Pro Trp Arg Cys Asp Ser Asp Ile Leu
             420                 425                 430

 ccg ctc cgc aac tgg ctc ctg ctc aac cag cct agg tta ggg acg gac     1344
 Pro Leu Arg Asn Trp Leu Leu Leu Asn Gln Pro Arg Leu Gly Thr Asp
         435                 440                 445

 act gta cct gtg tgt ttc agc cca gcc aat gtc cga ggc cag tcc ctc     1392
 Thr Val Pro Val Cys Phe Ser Pro Ala Asn Val Arg Gly Gln Ser Leu
     450                 455                 460

 att atc atc aat gtc aac gtt gct gtt cca agc gtc cat gta cct gag     1440
 Ile Ile Ile Asn Val Asn Val Ala Val Pro Ser Val His Val Pro Glu
 465                 470                 475                 480

 gtg cct agt tac cca gaa aca cca tgg tac cca gac aca ccc agt tac     1488
 Val Pro Ser Tyr Pro Glu Thr Pro Trp Tyr Pro Asp Thr Pro Ser Tyr
                 485                 490                 495

 cct gac acc aca tcc gtc tct tct acc act gag cta acc agc cct gtg     1536
 Pro Asp Thr Thr Ser Val Ser Ser Thr Thr Glu Leu Thr Ser Pro Val
             500                 505                 510

 gaa gac tac act gat ctg act acc att cag gtc act gat gac cgc agc     1584
 Glu Asp Tyr Thr Asp Leu Thr Thr Ile Gln Val Thr Asp Asp Arg Ser
         515                 520                 525

 gtt tgg ggc atg acc cat gcc cat agc ggg ctg gcc att gcc gcc att     1632
 Val Trp Gly Met Thr His Ala His Ser Gly Leu Ala Ile Ala Ala Ile
     530                 535                 540

 gta att ggc att gtc gcc ctg gcc tgc tcc ctg gct gcc tgc gtc ggc     1680
 Val Ile Gly Ile Val Ala Leu Ala Cys Ser Leu Ala Ala Cys Val Gly
 545                 550                 555                 560

 tgt tgc tgc tgc aag aag agg agc caa gct gtc ctg atg cag atg aag     1728
 Cys Cys Cys Cys Lys Lys Arg Ser Gln Ala Val Leu Met Gln Met Lys
                 565                 570                 575

 gca ccc aat gag tgt taa                                             1746
 Ala Pro Asn Glu Cys 
             580





      <210> 347
      <211> 637
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (153)..(404)

      <400> 347
 gagggcatac ccacgtgtgg tggaattcca gtggagaggg cactgacagg aggtcagcct     60

 aaggacctgc tcccgtgtgc cctgtcacca gcctacgtct gacttcccca tggacttcaa    120

 ggtccaattg ccttagctgg aagccactgg gg  atg gga ctg aac atc cct ggg     173
                                      Met Gly Leu Asn Ile Pro Gly
                                        1               5

 ctt tgg tct ttg tca tca gtc ctc agt ttg act gga ctc aca tct cct      221
 Leu Trp Ser Leu Ser Ser Val Leu Ser Leu Thr Gly Leu Thr Ser Pro
          10                  15                  20

 gta gtc ttt ctg ggt tca aga gaa caa aat ccg ctg gcc aag agg ttg      269
 Val Val Phe Leu Gly Ser Arg Glu Gln Asn Pro Leu Ala Lys Arg Leu
      25                  30                  35

 gcc ctt aag gag ctc ctc ccc ttc aca cac tcc cag cag agc tcc tca      317
 Ala Leu Lys Glu Leu Leu Pro Phe Thr His Ser Gln Gln Ser Ser Ser
  40                  45                  50                  55

 gag ctg ccc ttg aga ccc ccc agg gca gcg cga agg ccc tgc cag cct      365
 Glu Leu Pro Leu Arg Pro Pro Arg Ala Ala Arg Arg Pro Cys Gln Pro
                  60                  65                  70

 aac tct gtg gga gga aca gga cat gca gct aga tgc tag aggctggctc       414
 Asn Ser Val Gly Gly Thr Gly His Ala Ala Arg Cys 
              75                  80

 taggacaagt gaggttcctg agctgcagaa tggctccagc ctcaggccca gaacagcctg    474

 gttcaccagc aggtgctgat taaatccaga gaagagaccc gcatcgaaag gcacaagtca    534

 gagaccctca gggcccaagg gactctctga gtttggggaa aataaggcag gcaggaaaaa    594

 accagaaaca agagtagaag gggcatggaa ggcagaagat gga                      637




      <210> 348
      <211> 588
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (263)..(541)

      <400> 348
 acatcatacg ccagcttgga cgaggggaga gaggttgtgc ccgaaggtgg acactggggt     60

 atgctccctc caccacctca tcctccactg ctatcctcag tacagctgct tctggtaagc    120

 gtgcaggcca tggacgccac cctcgatctg ggctgacatg gtccacttct caaatttgag    180

 ctctcctgag tacatcatgg agccatgctg gttactcgct atgaggtagg gcacaaactt    240

 ctgaatggac cctttgtcct gg atg gag gcc gag aca ccc tgc aca ata ttc     292
                          Met Glu Ala Glu Thr Pro Cys Thr Ile Phe
                            1               5                  10

 acc ttt tcc ccc tcg ctg aag tat cgt ttc tgg ctg ctg ctg ctc ttc      340
 Thr Phe Ser Pro Ser Leu Lys Tyr Arg Phe Trp Leu Leu Leu Leu Phe
                  15                  20                  25

 tcc atg gca tct agc gag ccc atg ccc cag tac ttc ttg agc tgc acc      388
 Ser Met Ala Ser Ser Glu Pro Met Pro Gln Tyr Phe Leu Ser Cys Thr
              30                  35                  40

 ctg tct gag aag aag tac tcg ccg ctg ggc ctc cgt ggt ggt ggc cag      436
 Leu Ser Glu Lys Lys Tyr Ser Pro Leu Gly Leu Arg Gly Gly Gly Gln
          45                  50                  55

 cag gga gcc cat cat cac tgt gga ggc tcc aag ggc cag ggc ctt gac      484
 Gln Gly Ala His His His Cys Gly Gly Ser Lys Gly Gln Gly Leu Asp
      60                  65                  70

 cac gtg ccc cac ggt ctg gat gcc aca tcg gct atg atg gac aca cca      532
 His Val Pro His Gly Leu Asp Ala Thr Ser Ala Met Met Asp Thr Pro
  75                  80                  85                  90

 aag tgc tga gcgtact tggccacctt gtacacagca gtgccctggg gctgaccgca      588
 Lys Cys 






      <210> 349
      <211> 1342
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (414)..(521)

      <400> 349
 taagcttgga tcctctagag cggccgctgt cgttgttctg agatcccttt ctggacatga     60

 acgaacggct tcagagaagt ctagggacct gtccaaggac acagagcccc tgaaaggtag    120

 ctctgttgtc tgcaccaagt ctgtgtgact ctggcaccgc tcccggggtc attcacagca    180

 gggccccgct cagacctcgg cgggcagcga gaagaacaca tggagattct gacttccagc    240

 acaaaggggc atcctgcctt gtgtttttgt ttcccatctc tgagcattct ctctggatta    300

 cagccgtgac cgccgtatcg cagcgtgttt gcccatcccg gtttgagttg taagctggtg    360

 aaatagaaga atccttgtga aaatatgaac acacttttat ttaccaaagg taa   atg     416
                                                              Met
                                                                1

 aaa cct ttc act gtt ctg aag ggt ttc cat ttt tct gtc ttt tgt ctc      464
 Lys Pro Phe Thr Val Leu Lys Gly Phe His Phe Ser Val Phe Cys Leu
               5                  10                  15

 ctc cct ttg att acc cat aac att aac ctt caa aca acc tgg caa atc      512
 Leu Pro Leu Ile Thr His Asn Ile Asn Leu Gln Thr Thr Trp Gln Ile
          20                  25                  30

 cga gtc tga tttcccg gcagcctcct ccttcagcca ggcagggcac ctgttgcagg      568
 Arg Val 
      35

 ccctcttggg atcaccaggc agagaagctt ccctgtgctt cacacccact cacgcctgtc    628

 cccccgtcct gggggaaggc agttccaggc tggcccatgg tcactgtgaa gcgctcctac    688

 ttaacaatgc aagtagccat ccctctgtcc agctggcttt gacgaggctc tgccgccgca    748

 gcttcttgcc cgtggctctg tgatggggaa aaaaggaagg aaaaatgcgt tccatgcagg    808

 gcctgtcact gccgtagaaa cagcagtatt attttcaggg atgttgcgtt aataggggaa    868

 ggctgtttct tggaaaatac tgccttcaag tactgtgact cttttcaggt tatataaaag    928

 ggcattaggc aaacactcag aaattcagca gcttccttgg ttgggagtgt ggagggtggg    988

 tggaccagct cctgtgcacc tccagcggca gccacgcaga atacgaattg gctgcagtta   1048

 ccgtcctcat cagcccgcag tctggatagt atcagcaaca ggaaaggtta cagcttttcc   1108

 tgtgatgtat tgcttcttca gagagtatta aagatgtttt gaatctattt ttttaggaat   1168

 cttgaaacca ccagtggaac atttttgctg ttgtgggtaa tgcacaacgt agcagcgtag   1228

 gaaggccggg ccgcgagagg gaaccgaggg tgttggaagc accgaagacg gcgtccgttg   1288

 tcattttaac agtgaggaag caagtgaggc agagcatatg ctgaggcctc gtgc         1342




      <210> 350
      <211> 1206
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (291)..(878)

      <400> 350
 tattgaggca ctggcccagg gaactgagcc ttgggcctgt cctaaagctc cataggtgac     60

 tgcactgcag cccacatgga gagctgcagc tctaacacag ggattttgag aggcctcagt    120

 gccatttaag tggcacttcc aggacaccca tcctgagctc ccacaaaggg cgccaccttc    180

 ccaagaacgt ctaattgtca ttggaacagc cagtgtcagg cagcttctgc tcaggctgat    240

 gtggcgtctg acccttggtg ggttgccaga cattccttcc tgtttctgcc   atg gga     296
                                                          Met Gly
                                                            1

 agt tgg cac tgg gaa tgg tat gga gcc ccc act tct acc ctg agc ctt      344
 Ser Trp His Trp Glu Trp Tyr Gly Ala Pro Thr Ser Thr Leu Ser Leu
           5                  10                  15

 ggg tgt ctg ctg ctt cca ggt gaa aaa tgg aca ttt ctg ata ctg ccc      392
 Gly Cys Leu Leu Leu Pro Gly Glu Lys Trp Thr Phe Leu Ile Leu Pro
      20                  25                  30

 agc cac tac ggc acc aca acc cat gct cat agt ctc cag gga tgt gta      440
 Ser His Tyr Gly Thr Thr Thr His Ala His Ser Leu Gln Gly Cys Val
  35                  40                  45                  50

 gaa cgg caa tgg cag gac agc aaa caa ctg gcg att tcc cca ggt ccc      488
 Glu Arg Gln Trp Gln Asp Ser Lys Gln Leu Ala Ile Ser Pro Gly Pro
                  55                  60                  65

 acg ctc ttg cgg agt gag tat gtt ggg tcc ctg tcc cca gtg tgt tcc      536
 Thr Leu Leu Arg Ser Glu Tyr Val Gly Ser Leu Ser Pro Val Cys Ser
              70                  75                  80

 agc ctt acc cag gtg cac aga gta ccc tgg ggc cag cac agg gct tgt      584
 Ser Leu Thr Gln Val His Arg Val Pro Trp Gly Gln His Arg Ala Cys
          85                  90                  95

 cca gtg atg ctc ctg gtg ttc aca aaa tgg ctc cag aga tac ctg cat      632
 Pro Val Met Leu Leu Val Phe Thr Lys Trp Leu Gln Arg Tyr Leu His
     100                 105                 110

 ttt gaa aag cct gcc gag cca gca agt gta ggg cag gac ccg gat ttc      680
 Phe Glu Lys Pro Ala Glu Pro Ala Ser Val Gly Gln Asp Pro Asp Phe
 115                 120                 125                 130

 ttt ggc aaa tct gaa ggt gag agg gcc act tgc ctg ctg agt aga agc      728
 Phe Gly Lys Ser Glu Gly Glu Arg Ala Thr Cys Leu Leu Ser Arg Ser
                 135                 140                 145

 tgc ctt tac ctg gcc agt gta tgc aac ttg aga gaa aat gac agc tgc      776
 Cys Leu Tyr Leu Ala Ser Val Cys Asn Leu Arg Glu Asn Asp Ser Cys
             150                 155                 160

 atg ggg cgc tct ggt ggg act ggg aag tct gat ctt ccg ggg agc tgg      824
 Met Gly Arg Ser Gly Gly Thr Gly Lys Ser Asp Leu Pro Gly Ser Trp
         165                 170                 175

 agg tgg tgg aat ctg tcc att agt cca gtg gat ggg ttg agc acg gat      872
 Arg Trp Trp Asn Leu Ser Ile Ser Pro Val Asp Gly Leu Ser Thr Asp
     180                 185                 190

 ctc tga gctcacacac tggggcatgt gccactgctc tgactcacta atccactggc       928
 Leu 
 195

 tggttttcct gcttttctca cttaaatttc tttggttttc ttgaattttt gcccataaag    988

 atctcatttg cttcatgatc ttctcctata aaagaactat gaatgtgaac atcagagaaa   1048

 caaatcgctt tgggtttcag acccccattg ataaggaaat caagggatga gatataaaag   1108

 agatttggga agatctcaga ctgtagaacc acaacatgga acgcaaccag tttaattgga   1168

 aaatcataag cagggctaat ttgcagataa tgtggcat                           1206




      <210> 351
      <211> 3884
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (730)..(1623)

      <400> 351
 ttttttgcaa aaccatgtgt ttatttttat tagaaatgtt cttggtataa aaacaatcat     60

 gcgctacaca ttgtcgtcaa taaccatcac caaacaccca ggcactgaac tccgtgtggt    120

 cggcaggagg ggcaggcggg caggcgggca agacagacgg cagacgggcg gggcaggcgg    180

 gcaagacaca cggcagatgg gcggggcagg cgggcaggct gcgggccaca gggacacaca    240

 cagaggccac caggaggacg cagcacttgg caacacactc gagatttgtt ttcgttttgg    300

 cttttttgtg ttttgatttt ttttcctttt ttctcttttg caacatgtaa ggtttggtga    360

 actggggaag ggtggcaggg agaggggagc aatggctgga cgagaatgaa gcagaggaga    420

 acaggaaaga aaacggcaga aaagtgacac tggtgggacc caagaaagca ggaggagctg    480

 aggacaaaga ggatgagaga gagaggcgga ggcaagagcc agaaaggaga cacagaaaag    540

 gccaagagta caagcagccg gggacgccag agagggaaaa ggtgaaacaa agagataaga    600

 gaacagaaag acagggctgg agacagacag aggggtcgcc aacagcacag acagagacga    660

 agggagggag agatctagca ctggggccca cacgacctga gcccctgtgg tttggggccg    720

 ggaggggca    atg gtc caa gac gca ggt tct tgt ggt agc ctg gca ccg     768
              Met Val Gln Asp Ala Gly Ser Cys Gly Ser Leu Ala Pro
                1               5                  10

 ccc cgg ccc ctc gtc ctc ctg ttg ctc acc cgg ttt gcc cag gct gcc      816
 Pro Arg Pro Leu Val Leu Leu Leu Leu Thr Arg Phe Ala Gln Ala Ala
      15                  20                  25

 agc agt gat ggc tgg ggg ctc tgc tat cct cag cac caa gcc acg tcc      864
 Ser Ser Asp Gly Trp Gly Leu Cys Tyr Pro Gln His Gln Ala Thr Ser
  30                  35                  40                  45

 gtg ggt gcc cac ggg cag gca aga cag ctg ggc cct tgg gtg tgg ccc      912
 Val Gly Ala His Gly Gln Ala Arg Gln Leu Gly Pro Trp Val Trp Pro
                  50                  55                  60

 tgg ccc gac gca cct tcc aca ggg tca cgg ctc ctc ctc ctg ctg ctc      960
 Trp Pro Asp Ala Pro Ser Thr Gly Ser Arg Leu Leu Leu Leu Leu Leu
              65                  70                  75

 agc tcc atg gac tcg cta gat tgc atg gtt ggt gta agt gac gta agt     1008
 Ser Ser Met Asp Ser Leu Asp Cys Met Val Gly Val Ser Asp Val Ser
          80                  85                  90

 ctg ttt ggt ggc cag cgc tgg ggc ctc aag gtt ctc gca gag ctc aga     1056
 Leu Phe Gly Gly Gln Arg Trp Gly Leu Lys Val Leu Ala Glu Leu Arg
      95                 100                 105

 ctt ggc ctc tcc gtt ggg ccg gaa gtt gcc ctt ctg cgt gaa ctt gtt     1104
 Leu Gly Leu Ser Val Gly Pro Glu Val Ala Leu Leu Arg Glu Leu Val
 110                 115                 120                 125

 gga cat ggt ggc cgc cgt aac gac ggc ttt gag gct gcg ctt gcg ctt     1152
 Gly His Gly Gly Arg Arg Asn Asp Gly Phe Glu Ala Ala Leu Ala Leu
                 130                 135                 140

 ggg cac gtt ctg ctc cgg gtg gaa gag gat gat gta gac ttt ggg cat     1200
 Gly His Val Leu Leu Arg Val Glu Glu Asp Asp Val Asp Phe Gly His
             145                 150                 155

 gta gag cat tcc cag gga cac cga ggc gct cag act cac cga gac cgt     1248
 Val Glu His Ser Gln Gly His Arg Gly Ala Gln Thr His Arg Asp Arg
         160                 165                 170

 cag cgt cgt cgt ctg gat gta cag ctt gtc ggc cga ctg cga ggt gcc     1296
 Gln Arg Arg Arg Leu Asp Val Gln Leu Val Gly Arg Leu Arg Gly Ala
     175                 180                 185

 aaa gaa gat ggg gat gaa ggc cag cca gac gat gca agt ggt gta cat     1344
 Lys Glu Asp Gly Asp Glu Gly Gln Pro Asp Asp Ala Ser Gly Val His
 190                 195                 200                 205

 ggt gaa gcc aat ggg ctt ggc ctc att gaa ggt ctc ggg cac gcc gcg     1392
 Gly Glu Ala Asn Gly Leu Gly Leu Ile Glu Gly Leu Gly His Ala Ala
                 210                 215                 220

 tgt ctt gat ggc ata cac ggt gca cgt gac cat gag cag cat gct gta     1440
 Cys Leu Asp Gly Ile His Gly Ala Arg Asp His Glu Gln His Ala Val
             225                 230                 235

 gcc cag cag gca gat gag cga cag gtc cga gat gtc aca ctt gag cac     1488
 Ala Gln Gln Ala Asp Glu Arg Gln Val Arg Asp Val Thr Leu Glu His
         240                 245                 250

 acc cct ggc gaa gcg ggg gtc gag tgt ccg ctg gtc ctg gaa gtc cac     1536
 Thr Pro Gly Glu Ala Gly Val Glu Cys Pro Leu Val Leu Glu Val His
     255                 260                 265

 cac cga gtg gga ggg gtc cac cac aaa cca cac aca gat gcc cag cag     1584
 His Arg Val Gly Gly Val His His Lys Pro His Thr Asp Ala Gln Gln
 270                 275                 280                 285

 ctg cag cga gat gag gct gaa ggt gat ggc cag ctg tga ggcggggctg      1633
 Leu Gln Arg Asp Glu Ala Glu Gly Asp Gly Gln Leu 
                 290                 295

 atgaagcgtg gggcactgac cgagcgcttg ccctgctcga agatgcggta gatgcggttg   1693

 gtcttggtga gcagggctgc atagctgatg ctcatcccta gtcccaggaa gattcggcgc   1753

 agcgagcagg tgccaaggtc gggctcagcg atcatgagga aggtggtggc atagcacagg   1813

 aagatgcctg ccagcagcac gtagctcagt tcacggcccg aggccttgac gatgggcgtg   1873

 tcgttgtagc gcacaaaggt gatcaccacg aacaacgtgg cagcgatgcc caccacggcc   1933

 aggaagaggg gcagcacggc ccagggcgag ccccactcaa gcttgatgat ggggatgggc   1993

 cggcagcccg tgcggttctc tgtgggccgc atgtcatagg gacacgtctt acaggtgtag   2053

 cggtccacct ggtactggta ccctgtgcaa ggctcgcagt gccagcagca aggcatgccc   2113

 ttcactgtct tcttccgctc acccggttgg cagggcaggc tgcagatgga gcggggcagc   2173

 tgctgcccgc tccccggcca gtgcatccgc tctattctaa ggtgcaggtg gtcagtccag   2233

 gagccaatga ccttgtactc ggcagaatcg ttgcgcagct ggtattggta gatgtcatag   2293

 cgcccaggcg catctccatt ctcattgaag gtcacagggt tccctgcgat gcctgagaag   2353

 ttgacgtttc ggatgtactt aagcagctgg gtgccatcta cagggtccat gcgcgggcag   2413

 agccccacgc ggccgggaca caggtcacgg tgcatggcgt gcagcgcgtg gcccatggcg   2473

 tacacggcat cgatcacaaa ctgcaccttc ccctcctgct cataagctga atcctgccca   2533

 attcgctcac ggttggtgca cttcttgacg tggctgccct tcttgagggc gtggcggctc   2593

 agcttgcagt ggaagttgtc ctcccagaac tcggcaaacc agatgttgcg ccggttgttg   2653

 tccagcgtgc ggctggagaa gtagcggtcg aagcctcgta cggacatcct cttggggagg   2713

 atcgtgacag caccctcagc cacctcctcc aggtgcagca caggtgcaat cttggagccc   2773

 cagctgtcag agcccatcca gaagaaatgg cctgtctggt tggcccttcg tgctgcctcc   2833

 agcacacgcc tgatgtcatc ctcgttggca aagatgatga ctgccctggc gttcgaagtc   2893

 tccaggaggc ggcggatgat cttgtcgaac tcgcctgcct tgggctcccg tggtatcttc   2953

 accgactggg cgatgcacac gcccccgtcc tcacgggact tctggatgaa ggcctccaca   3013

 ccgctctcac catagctgcc ctccgaggcc actgtggaca catagttcca cttgagggca   3073

 cggacgatgt ccaccatggc ctgggcctgg tacgtgtccg agggcaccac gcgggagaag   3133

 aagtcgtagc ggctgttgtc actcaggtct ggcgctgtgg aggcgtagct gatctggggt   3193

 atcttgaaga ggcgaaggat gttggccacc atgatggaga ccgagctccc tgaagcaccg   3253

 atgacaccca ccacacgttc aggcttggtg atgatgggtg ggccgccact gccacagcgg   3313

 acctctgtgc catccttctc gatgagcgcc tgcacaaagg tcagcgactg ctcgagggca   3373

 tgggtgtccc tggagcaggt gtccagaatg cgggcgccca gcgtgatgtt aggcagcagg   3433

 tccgggtcgt tgttgatgcg atccagggcg aacagcatgg cctccagccg gtggatgccc   3493

 ttttccttct taagttctcc acagggcttg ccctctgagc cccggccatg caccgggaac   3553

 aggcctccca gtgtgatgtc cccatctatg cggatggaat tcatgtgagg gtggcctttg   3613

 ggctttccca gggaggaagg catccagggg ccgtaaaggc tgaggagcag gcaaaggggc   3673

 agccgggccc accaccagcc caagcctctc ttcccaggca tctcggaaat ccctagagac   3733

 ccatgaacgg caggcccact cctagccctg gcaggcccct ggccccacgg cctgggtggg   3793

 catgggcagg gcagcttcag cagcaggggg actgagggca gccaaccgcg tagcccatgc   3853

 tgctaccctc tcccacctcc ttgtcactcg g                                  3884




      <210> 352
      <211> 3136
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (827)..(3136)

      <400> 352
 tgtctcataa tttctttgaa attcaaccat gatcttgcat gtttcagaag tttgttcatg     60

 ttataacaga ggagtatttc aatgaatgaa tatatcagtt tgtttatcca ttcacctatc    120

 aaggactggt tcttggtttc cagattgtag aatacattta tgaataatac tgctatgaac    180

 attcatagac aagactatgt ggtaagttcc taggactgaa attgctggat caaagcgtag    240

 gtatatgttt aacttgataa gaaattatag ttacacaccc taatttttct catgacattt    300

 tactctccag ttcatccatt accctcagct ccatttgatt tctataacct ctaagtctat    360

 cctcaaaatt cttttaagaa gtttctactt tccttatcat tgtatatgct tccctctttt    420

 aattacatgt tgaatccttc cctcatttag gcttgagaaa aatgtcctta agtgtcgtaa    480

 acttgcatca aacccactta ctcatcaaac cccacttatg acttccctta gaggacaagc    540

 gacatttcag ctcagttata cactgctttt ctcaattcct gccatttttt tctcttcctt    600

 tgccccctgg cctacgtctc cagctcactg aaaacagcct cccctgatga gcacaccatt    660

 gttatgtaat agcctaaccc ttacccctcg cctatcaggg ggtgccaagc ctgcagactc    720

 actctgcctt cctcaaaact gccctgagga gaaggctgaa gactgaggaa tcctctttct    780

 gcctcccatt tgactgcatt ttctttggtc aaaggcttcc ttattc   atg gga cct     835
                                                      Met Gly Pro
                                                        1

 gcc tgg gtc cag gac ccc ttg aca ggt gct ctc tgg ctg cct gtc ctc      883
 Ala Trp Val Gln Asp Pro Leu Thr Gly Ala Leu Trp Leu Pro Val Leu
       5                  10                  15

 tgg gca ctc ttg tcc cag gtc tat tgt ttt cat gac cca cca gga tgg      931
 Trp Ala Leu Leu Ser Gln Val Tyr Cys Phe His Asp Pro Pro Gly Trp
  20                  25                  30                  35

 cgc ttc act tcc tca gaa att gtg atc ccc agg aaa gtg ccc cac aag      979
 Arg Phe Thr Ser Ser Glu Ile Val Ile Pro Arg Lys Val Pro His Lys
                  40                  45                  50

 agg ggt gga gtt gag atg cca gac cag ctc tct tac agc atg cgt ttc     1027
 Arg Gly Gly Val Glu Met Pro Asp Gln Leu Ser Tyr Ser Met Arg Phe
              55                  60                  65

 cgg ggc caa aga cac gtg att cac atg aag ctc aag aag aac atg atg     1075
 Arg Gly Gln Arg His Val Ile His Met Lys Leu Lys Lys Asn Met Met
          70                  75                  80

 ccc aga cat tta cct gtt ttt act gat aat gac caa ggg gcc atg cag     1123
 Pro Arg His Leu Pro Val Phe Thr Asp Asn Asp Gln Gly Ala Met Gln
      85                  90                  95

 gag aac tac cct ttt gtc cca cga gac tgt tac tat gac tgc tac ctg     1171
 Glu Asn Tyr Pro Phe Val Pro Arg Asp Cys Tyr Tyr Asp Cys Tyr Leu
 100                 105                 110                 115

 gaa ggg gtt cct ggg tct gcg gcc aca ttg gac acc tgc cgt gga ggt     1219
 Glu Gly Val Pro Gly Ser Ala Ala Thr Leu Asp Thr Cys Arg Gly Gly
                 120                 125                 130

 ctg cat ggc atg ctg cag gtg gat gac ttg act tac gaa atc aaa cac     1267
 Leu His Gly Met Leu Gln Val Asp Asp Leu Thr Tyr Glu Ile Lys His
             135                 140                 145

 ctg gag gct tct tcc aaa ttt gag cat gta gta tct ctg ctt gtg tca     1315
 Leu Glu Ala Ser Ser Lys Phe Glu His Val Val Ser Leu Leu Val Ser
         150                 155                 160

 gaa gaa aga cca gga gag gct agt aga tgt aag act gaa ggg gaa gag     1363
 Glu Glu Arg Pro Gly Glu Ala Ser Arg Cys Lys Thr Glu Gly Glu Glu
     165                 170                 175

 ata gat caa gaa tct gaa aag gta aaa ctg gct gaa act ccc aga gca     1411
 Ile Asp Gln Glu Ser Glu Lys Val Lys Leu Ala Glu Thr Pro Arg Ala
 180                 185                 190                 195

 ggc cac gtt tat ttg tgg agg cat cat aga aaa aac ttg aaa att cac     1459
 Gly His Val Tyr Leu Trp Arg His His Arg Lys Asn Leu Lys Ile His
                 200                 205                 210

 tac acg gtt act cgt gga tta ttc atg cgg aac cct aat gtg tca cat     1507
 Tyr Thr Val Thr Arg Gly Leu Phe Met Arg Asn Pro Asn Val Ser His
             215                 220                 225

 ata ata gag aat gta gtg att att aac agc atc ata cat acc att ttc     1555
 Ile Ile Glu Asn Val Val Ile Ile Asn Ser Ile Ile His Thr Ile Phe
         230                 235                 240

 aaa cca gtt tat tta aat gtc tat ata tgt gtt ttg tgc ata tgg aat     1603
 Lys Pro Val Tyr Leu Asn Val Tyr Ile Cys Val Leu Cys Ile Trp Asn
     245                 250                 255

 caa aag gat gca gta cta ttt tct gct agc agg cca ggc cac gtt gct     1651
 Gln Lys Asp Ala Val Leu Phe Ser Ala Ser Arg Pro Gly His Val Ala
 260                 265                 270                 275

 gta gaa ctg ttt ggt gtg tgg aaa tat cac aat ttg tat tca gaa att     1699
 Val Glu Leu Phe Gly Val Trp Lys Tyr His Asn Leu Tyr Ser Glu Ile
                 280                 285                 290

 tca cat gat acc tca gtt gtt ttt aca tca aat cga ctt gga aac agt     1747
 Ser His Asp Thr Ser Val Val Phe Thr Ser Asn Arg Leu Gly Asn Ser
             295                 300                 305

 gag tgt tat gcc agc ttt gat gga ata tgc acc ccc aac tgg gga gca     1795
 Glu Cys Tyr Ala Ser Phe Asp Gly Ile Cys Thr Pro Asn Trp Gly Ala
         310                 315                 320

 atg ttt gtg tat ata atg agg tat cac cta ttt agg ggg gca tgt gtt     1843
 Met Phe Val Tyr Ile Met Arg Tyr His Leu Phe Arg Gly Ala Cys Val
     325                 330                 335

 aca gca cat gca cta ggt cat aac atg ggc ttg aga cat gat tct gtt     1891
 Thr Ala His Ala Leu Gly His Asn Met Gly Leu Arg His Asp Ser Val
 340                 345                 350                 355

 ggt tgt tat tgt ttt cga cga acc aac tgt ctc atg acc cgt gtc cct     1939
 Gly Cys Tyr Cys Phe Arg Arg Thr Asn Cys Leu Met Thr Arg Val Pro
                 360                 365                 370

 gat ctt aat gat atg atg agc aat tgt tct tat gag ata att caa cgc     1987
 Asp Leu Asn Asp Met Met Ser Asn Cys Ser Tyr Glu Ile Ile Gln Arg
             375                 380                 385

 aag ttt aat caa tgg gat cct tgt ttg agt gct cca aat gtt cca tac     2035
 Lys Phe Asn Gln Trp Asp Pro Cys Leu Ser Ala Pro Asn Val Pro Tyr
         390                 395                 400

 act aat ttt cca tac gta gct cct cgt tgt gga gac aag atc aaa aat     2083
 Thr Asn Phe Pro Tyr Val Ala Pro Arg Cys Gly Asp Lys Ile Lys Asn
     405                 410                 415

 cag agg gaa gaa tgt gac tgt ggc tcc ctt aaa gat tgt gcc agt gat     2131
 Gln Arg Glu Glu Cys Asp Cys Gly Ser Leu Lys Asp Cys Ala Ser Asp
 420                 425                 430                 435

 aga tgt tgt gag acc tct tgt acc ctt tct ctt ggc agt gtt tgc aat     2179
 Arg Cys Cys Glu Thr Ser Cys Thr Leu Ser Leu Gly Ser Val Cys Asn
                 440                 445                 450

 aca gga ctt tgc tgc cat aag tgt aaa tat gct gcc cct gga gtg gtt     2227
 Thr Gly Leu Cys Cys His Lys Cys Lys Tyr Ala Ala Pro Gly Val Val
             455                 460                 465

 tgc aga gac ttg ggt ggt ata tgt gat cta ccg gaa tac tgt gat ggg     2275
 Cys Arg Asp Leu Gly Gly Ile Cys Asp Leu Pro Glu Tyr Cys Asp Gly
         470                 475                 480

 aaa aag gaa gag tgt cca aat gac atc tac atc cag gat gga acc cca     2323
 Lys Lys Glu Glu Cys Pro Asn Asp Ile Tyr Ile Gln Asp Gly Thr Pro
     485                 490                 495

 tgt tca gca gta tct gtt tgt ata aga gga aac tgc agt gac cgt gat     2371
 Cys Ser Ala Val Ser Val Cys Ile Arg Gly Asn Cys Ser Asp Arg Asp
 500                 505                 510                 515

 atg cag tgt caa gcc ctt ttt ggc tac caa gtg aaa gac ggt tcc cca     2419
 Met Gln Cys Gln Ala Leu Phe Gly Tyr Gln Val Lys Asp Gly Ser Pro
                 520                 525                 530

 gcg tgc tat cga aaa ttg aat agg att ggt aac cga ttt gga aac tgt     2467
 Ala Cys Tyr Arg Lys Leu Asn Arg Ile Gly Asn Arg Phe Gly Asn Cys
             535                 540                 545

 ggg gtt att cta cgg cga ggg gga agt aga cct ttt cca tgt gaa gaa     2515
 Gly Val Ile Leu Arg Arg Gly Gly Ser Arg Pro Phe Pro Cys Glu Glu
         550                 555                 560

 gat gat gtt ttt tgt gga atg ttg cac tgt agc ggt gtc agc cac att     2563
 Asp Asp Val Phe Cys Gly Met Leu His Cys Ser Gly Val Ser His Ile
     565                 570                 575

 ccc ggt gga gta cac gac ata aaa gaa gaa aaa tgc ttt ggc tat gaa     2611
 Pro Gly Gly Val His Asp Ile Lys Glu Glu Lys Cys Phe Gly Tyr Glu
 580                 585                 590                 595

 gca cac cag ggg aca gac ttg cca gaa atg ggg ctg gta gtg gat ggt     2659
 Ala His Gln Gly Thr Asp Leu Pro Glu Met Gly Leu Val Val Asp Gly
                 600                 605                 610

 gca acc tgt ggc cca ggg agc tac tgt ctt aaa cgc aat tgt act ttt     2707
 Ala Thr Cys Gly Pro Gly Ser Tyr Cys Leu Lys Arg Asn Cys Thr Phe
             615                 620                 625

 tat caa gac ctg cat ttt gag tgt gat ctt aaa aca tgc aat tac aaa     2755
 Tyr Gln Asp Leu His Phe Glu Cys Asp Leu Lys Thr Cys Asn Tyr Lys
         630                 635                 640

 gga gta tgt aac aac aaa aaa cat tgt cat tgt ctg cat gag tgg caa     2803
 Gly Val Cys Asn Asn Lys Lys His Cys His Cys Leu His Glu Trp Gln
     645                 650                 655

 cca cca aca tgt gaa ctg aga gga aaa gga ggt agt ata gat agt ggc     2851
 Pro Pro Thr Cys Glu Leu Arg Gly Lys Gly Gly Ser Ile Asp Ser Gly
 660                 665                 670                 675

 cct cta cct gac aaa caa tat cgt att gca ggc agc ata ctt aca gag     2899
 Pro Leu Pro Asp Lys Gln Tyr Arg Ile Ala Gly Ser Ile Leu Thr Glu
                 680                 685                 690

 gtt aaa ggc att att caa ttg aac tac atg agg gag tac ctg aag acc     2947
 Val Lys Gly Ile Ile Gln Leu Asn Tyr Met Arg Glu Tyr Leu Lys Thr
             695                 700                 705

 agt tcc aaa gcc tgg gaa aat gga tct cag cat gga aag gaa ctt aga     2995
 Ser Ser Lys Ala Trp Glu Asn Gly Ser Gln His Gly Lys Glu Leu Arg
         710                 715                 720

 att gtg aca tat aag tgg att ttc tat aaa atc tca ttt agt acg ctt     3043
 Ile Val Thr Tyr Lys Trp Ile Phe Tyr Lys Ile Ser Phe Ser Thr Leu
     725                 730                 735

 gtg tat cac tac ttt ata aac gaa gga gcc caa gtt tat aat ttg gct     3091
 Val Tyr His Tyr Phe Ile Asn Glu Gly Ala Gln Val Tyr Asn Leu Ala
 740                 745                 750                 755

 ggc att gaa gga gga gta cct ggt ggc aaa gtg tta ggt atc tga         3136
 Gly Ile Glu Gly Gly Val Pro Gly Gly Lys Val Leu Gly Ile 
                 760                 765





      <210> 353
      <211> 4416
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (272)..(1594)

      <400> 353
 atgacccact tgctttgtcc agagactcgt cacactgaaa ctattttccg tttgagacct     60

 tccaggagga aagccatcct cacacgcatg cagtacaaac cagtgtcctc cagagtccgc    120

 tgtgcctacg gccagagcag cgacagagcc ttcctcaaac ctgtagtgac tgccacactt    180

 tgcaaggaca ccgtagaggg ggcatgtccg cgctccaact tcctcccgac gcagcctctg    240

 attggctcct gggcttataa gaaacgcgtg a   atg agc agc tgc cgc ggg cag     292
                                      Met Ser Ser Cys Arg Gly Gln
                                        1               5

 aaa gtt gcc gga ggt ctc cgg gtg gta tcg ccc ttt cct ctt tgc cag      340
 Lys Val Ala Gly Gly Leu Arg Val Val Ser Pro Phe Pro Leu Cys Gln
          10                  15                  20

 ccc gct ggc gag ccg agc cgg ggc aag atg agg tcg tcc tgt gtc ctg      388
 Pro Ala Gly Glu Pro Ser Arg Gly Lys Met Arg Ser Ser Cys Val Leu
      25                  30                  35

 ctc acc gcc ctg gtg gcg ctg gcc gcc tat tac gtc tac atc ccg ctg      436
 Leu Thr Ala Leu Val Ala Leu Ala Ala Tyr Tyr Val Tyr Ile Pro Leu
  40                  45                  50                  55

 cct ggc tcc gtg tcc gac ccc tgg aag ctg atg ctg ctg gac gcc act      484
 Pro Gly Ser Val Ser Asp Pro Trp Lys Leu Met Leu Leu Asp Ala Thr
                  60                  65                  70

 ttc cgg ggt gca cag caa gtg agt aac ctg atc cac tac ctg gga ctg      532
 Phe Arg Gly Ala Gln Gln Val Ser Asn Leu Ile His Tyr Leu Gly Leu
              75                  80                  85

 agc cat cac ctg ctg gca ctg aat ttt atc att gtt tct ttt ggc aaa      580
 Ser His His Leu Leu Ala Leu Asn Phe Ile Ile Val Ser Phe Gly Lys
          90                  95                 100

 aaa agc gcg tgg tct tct gcc caa gtg aag gtg acc gac aca gac ttt      628
 Lys Ser Ala Trp Ser Ser Ala Gln Val Lys Val Thr Asp Thr Asp Phe
     105                 110                 115

 gat ggt gtg gaa gtc aga gtg ttt gaa ggc cct ccg aag ccc gaa gag      676
 Asp Gly Val Glu Val Arg Val Phe Glu Gly Pro Pro Lys Pro Glu Glu
 120                 125                 130                 135

 cca ctg aaa cgc agc gtc gtt tat atc cac gga gga ggc tgg gcc ttg      724
 Pro Leu Lys Arg Ser Val Val Tyr Ile His Gly Gly Gly Trp Ala Leu
                 140                 145                 150

 gca agt gca aaa atc agg tat tat gat gag ctg tgt aca gca atg gct      772
 Ala Ser Ala Lys Ile Arg Tyr Tyr Asp Glu Leu Cys Thr Ala Met Ala
             155                 160                 165

 gag gaa ttg aat gct gtc att gtt tcc att gaa tac agg cta gtt cca      820
 Glu Glu Leu Asn Ala Val Ile Val Ser Ile Glu Tyr Arg Leu Val Pro
         170                 175                 180

 aag gtt tat ttt cct gag caa att cat gat gtt gta cgg gcc aca aag      868
 Lys Val Tyr Phe Pro Glu Gln Ile His Asp Val Val Arg Ala Thr Lys
     185                 190                 195

 tat ttc ctg aag cca gaa gtc tta cag aag tat atg gtt gat cca ggc      916
 Tyr Phe Leu Lys Pro Glu Val Leu Gln Lys Tyr Met Val Asp Pro Gly
 200                 205                 210                 215

 aga att tgc att tct ggt gac agt gct ggt gga aat ctg gct gct gcc      964
 Arg Ile Cys Ile Ser Gly Asp Ser Ala Gly Gly Asn Leu Ala Ala Ala
                 220                 225                 230

 ctt gga caa cag ttt act caa gat gcc agc cta aaa aat aag ctc aaa     1012
 Leu Gly Gln Gln Phe Thr Gln Asp Ala Ser Leu Lys Asn Lys Leu Lys
             235                 240                 245

 cta caa gct tta att tat cca gtt ctt caa gct tta gat ttt aac aca     1060
 Leu Gln Ala Leu Ile Tyr Pro Val Leu Gln Ala Leu Asp Phe Asn Thr
         250                 255                 260

 cca tct tat cag caa aat gtg aac acc cca atc ctg ccc cgc tat gtc     1108
 Pro Ser Tyr Gln Gln Asn Val Asn Thr Pro Ile Leu Pro Arg Tyr Val
     265                 270                 275

 atg gtg aag tat tgg gtg gac tac ttc aaa ggc aac tat gac ttt gtg     1156
 Met Val Lys Tyr Trp Val Asp Tyr Phe Lys Gly Asn Tyr Asp Phe Val
 280                 285                 290                 295

 cag gca atg atc gtt aac aat cac act tca ctt gat gtg gaa gag gct     1204
 Gln Ala Met Ile Val Asn Asn His Thr Ser Leu Asp Val Glu Glu Ala
                 300                 305                 310

 gct gct gtc agg gcc cgt cta aac tgg aca tcc ctc ttg cct gca tcc     1252
 Ala Ala Val Arg Ala Arg Leu Asn Trp Thr Ser Leu Leu Pro Ala Ser
             315                 320                 325

 ttc aca aag aac tac aag cct gtt gta cag acc aca ggc aat gcc agg     1300
 Phe Thr Lys Asn Tyr Lys Pro Val Val Gln Thr Thr Gly Asn Ala Arg
         330                 335                 340

 att gtc cag gag ctt cct cag ttg ctg gat gcc cgc tcc gcc cca ctc     1348
 Ile Val Gln Glu Leu Pro Gln Leu Leu Asp Ala Arg Ser Ala Pro Leu
     345                 350                 355

 att gca gac cag gca gtg ctg cag ctc ctc cca aag acc tac att ctg     1396
 Ile Ala Asp Gln Ala Val Leu Gln Leu Leu Pro Lys Thr Tyr Ile Leu
 360                 365                 370                 375

 acg tgt gag cat gat gtc ctc aga gac gat ggc atc atg tat gcc aag     1444
 Thr Cys Glu His Asp Val Leu Arg Asp Asp Gly Ile Met Tyr Ala Lys
                 380                 385                 390

 cgt ttg gag agt gcc ggt gtg gag gtg acc ctg gat cac ttt gag gat     1492
 Arg Leu Glu Ser Ala Gly Val Glu Val Thr Leu Asp His Phe Glu Asp
             395                 400                 405

 ggc ttt cac gga tgt atg att ttc act agc tgg ccc acc aac ttc tca     1540
 Gly Phe His Gly Cys Met Ile Phe Thr Ser Trp Pro Thr Asn Phe Ser
         410                 415                 420

 gtg gga atc cgg act agg aat agt tac atc aag tgg cta gat caa aac     1588
 Val Gly Ile Arg Thr Arg Asn Ser Tyr Ile Lys Trp Leu Asp Gln Asn
     425                 430                 435

 ctg taa aggagcaaaa cttccagaag cctcgagccc ctcttgacct cctacacctg      1644
 Leu 
 440

 ctttggaaag acatgcactt tttagttgac taattcttcc tcccattccc ctctacttgc   1704

 gagttatgga atttctattc cataactgaa gtctttatga taacctaatt tttaaaaatg   1764

 aatttgacta acttaagtgc aaaacatgta aatttggttc ccagagtggg ccaatctctc   1824

 tgttcttgtt atcttagcca actatactga tacctacagc tacagaaagc aggactagga   1884

 actggaaata actttgggtc ctgccttcat taggacgttc tttttagaag cagttcttcc   1944

 agctctggat catagagtga cctttaataa gttaaaaaaa cgaggactcc ttaattctgc   2004

 tagagttaac cttgagttca gagcagtatt aaatgcgtgc actttcaggt cagtactggg   2064

 gaccaagtac cctctggtct tttgtgaatg gatggttttg tttcctatgg gaattttggc   2124

 aaaggttttc tggaaagaac aagtttctca aaggactttc ttcctctaga atgttcattt   2184

 tatgagatcg ctatctgtaa gtccagttgg attacaggaa tacttgaaag ttactttcta   2244

 ccactattag aaaatatgaa gtcgcatgca ctggatatct atatatcatt aggtttttgt   2304

 tgtgtttttg gttatgctgt cccccttctc cttggggaga tatttgggag caaacttatt   2364

 tagatttaga gtaaactttt cattatagag caagtaaaaa cagacaaatg aaacaaccta   2424

 gtgtttcaca taaaaatact tctgacataa agtaccaaga gcagtgtgaa tatacttggc   2484

 atagtcaaaa aagaaaatac atttaatatt agttaaaaat tgttaaaaat acctttagaa   2544

 ggtctagtct attattgaaa actcaatttt ttcacttata tggctttaaa atggagctat   2604

 tttgctacaa tataatgtat tgtttatttt tttaagttat ttaatgttaa tatacatagc   2664

 tagacttaag gtttttcaga aagatgtcca taataaatat taaaaacaat ggtattttta   2724

 aaaaaactgc cttagggttt taaaaccttc cctacagtta taaccacgtg taattttgtg   2784

 gaaatgatat aacagctatt aatactacta taacataggc ataaatattt tcgtgtttat   2844

 atgcatatac aagttaaaat aattagaaac tatgactgcg cctagtaaag tcatctaggt   2904

 ttatagttca gtagcttagg caaggcacac actgctcatc tccgcttttt agggtcagag   2964

 gaacacaagc tcatgttctg agtgaagggc gtacactggc acctggtgtt gcctagatcc   3024

 cccatctcct ccttccagcc aggtctggaa gtttcaacag cccaagctta acttcatgta   3084

 aagtcttcac tgccagtggg aacatctttg acacaacaag acactccaat tgtgatttga   3144

 gttgaggatc tctgcctgcc ttcctgccgt ccttccttct tccccgatcc atgctacttt   3204

 taggggctgc ggagagcagc agcagagctg agtaatgata cagggcacca cggagagaaa   3264

 gtagaaccat ttcactcctg ggaagatggg gtatttccca cttccagcaa cgaaataaca   3324

 aatgaaaagt tgcatactta ttgatgtatt gtatgagcca gtagcatttt atgtacaaaa   3384

 cagaagtcaa tgcaacagta tgtatgtgtg cctgtgtgtg tataaaaata accattgaag   3444

 ctaacttgct aatgtactta ggcaagccac ttcccatctc tgggcctcgt ctttcctccc   3504

 tctaaaatca aagagctgaa ttatgtgatc cttgaggtct cttccactta taataccaac   3564

 tgtcttgtca gactggcaaa ttatattggc ctctccttat gtggtggttt ttttggtagg   3624

 tcatagttcc ttatacacgg acacctgcat catcgaaggt ctttttttcc taaaaaaaaa   3684

 aaatgggatt ttagttctta ttctgtgata actatcctcc tcatataata ctattctttt   3744

 tgacaccatt tgaaggaacc aatatttgga ccttattttg aggttgtctg tctcgaagaa   3804

 aaagaaaata aaatgtatag gcagggttcc ttcaattggc attttcccca gaattgtgag   3864

 ccaaagccta tagtaattgc agacagcaaa tgattccgga tctctaaaag gctctctcag   3924

 atgaaaaggg agtaaaggaa aaaagaggga ggtcaaccac tgtttctgat aatgtacttg   3984

 agtttcattg ttcttttagt ttgtattctt ataaaaaatg tttacactct gcagattgat   4044

 tttttttttt tagtactgtg gctttctttt cctattttat gaaaaaaatg ataatctttt   4104

 tgtaaaattg tctgtgaaat ataaacatta atatataaag aaaaaccttg aagtgctgta   4164

 tagtgaagta taaattaatg ttttattgat ttgtgaagaa tttaagacta ttatataatt   4224

 atcttggtgg atctatttta tgcatgacct tttaaccttt gactttgctt atttcccact   4284

 acgaagggga aggtagattt tatgaatgat tttaatagca aatatatttt ataaagtgaa   4344

 aatccagtgt ggaggtagca aagcatctat ctattctgaa tcatgtttgg aaataaaatt   4404

 gctccatctg gg                                                       4416




      <210> 354
      <211> 403
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (107)..(253)

      <400> 354
 ggggccagtt tcccccccaa aaccatagta agctgcagtc aacgtgagtc actgtaacaa     60

 gaaagagttc cctccatttt aaccctatta ggaaagtaac ttcgaa   atg acc cat     115
                                                      Met Thr His
                                                        1

 ctg ctt ttt gtt cgt ttt tgc ttt ctt cag ccc ttt tat gcc tat aaa      163
 Leu Leu Phe Val Arg Phe Cys Phe Leu Gln Pro Phe Tyr Ala Tyr Lys
       5                  10                  15

 gcc aac ctt ttt tgc tca gct cat gag aac act cta ttt tat aaa atg      211
 Ala Asn Leu Phe Cys Ser Ala His Glu Asn Thr Leu Phe Tyr Lys Met
  20                  25                  30                  35

 agg tgt tgt ttg att tta gaa tcc caa ata aaa acc aat taa agcttta      260
 Arg Cys Cys Leu Ile Leu Glu Ser Gln Ile Lys Thr Asn 
                  40                  45

 aagttgttgc aattttgtat tcaacatata aggcaggagg ttattttaaa taatccctgg    320

 tgtatttccc ctcaaaaaag caacttagca ttcaaataac ataaagaagg aagccctttg    380

 ttatgagtga atttcccatc tcc                                            403




      <210> 355
      <211> 1797
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (90)..(1274)

      <400> 355
 cccacgcgtc cgggcggcgt ccgccaggag gagcgcgcgg gcacagggtg ccgctgaccg     60

 aggcgtgcaa agactccaga attggaggc  atg atg aag act ctg ctg ctg ttt     113
                                  Met Met Lys Thr Leu Leu Leu Phe
                                    1               5

 gtg ggg ctg ctg ctg acc tgg gag agt ggg cag gtc ctg ggg gac cag      161
 Val Gly Leu Leu Leu Thr Trp Glu Ser Gly Gln Val Leu Gly Asp Gln
      10                  15                  20

 acg gtc tca gac aat gag ctc cag gaa atg tcc aat cag gga agt aag      209
 Thr Val Ser Asp Asn Glu Leu Gln Glu Met Ser Asn Gln Gly Ser Lys
  25                  30                  35                  40

 tac gtc aat aag gaa att caa aat gct gtc aac ggg gtg aaa cag ata      257
 Tyr Val Asn Lys Glu Ile Gln Asn Ala Val Asn Gly Val Lys Gln Ile
                  45                  50                  55

 aag act ctc ata gaa aaa aca aac gaa gag cgc aag aca ctg ctc agc      305
 Lys Thr Leu Ile Glu Lys Thr Asn Glu Glu Arg Lys Thr Leu Leu Ser
              60                  65                  70

 aac cta gaa gaa gcc aag aag aag aaa gag gat gcc cta aat gag acc      353
 Asn Leu Glu Glu Ala Lys Lys Lys Lys Glu Asp Ala Leu Asn Glu Thr
          75                  80                  85

 agg aat cag agc tcg ccc ttc tac ttc tgg atg aat ggt gac cgc atc      401
 Arg Asn Gln Ser Ser Pro Phe Tyr Phe Trp Met Asn Gly Asp Arg Ile
      90                  95                 100

 gac tcc ctg ctg gag aac gac cgg cag cag acg cac atg ctg gat gtc      449
 Asp Ser Leu Leu Glu Asn Asp Arg Gln Gln Thr His Met Leu Asp Val
 105                 110                 115                 120

 atg cag gac cac ttc agc cgc gcg tcc agc atc ata gac gag ctc ttc      497
 Met Gln Asp His Phe Ser Arg Ala Ser Ser Ile Ile Asp Glu Leu Phe
                 125                 130                 135

 cag gac agg ttc ttc acc cgg gag ccc cag gat acc tac cac tac ctg      545
 Gln Asp Arg Phe Phe Thr Arg Glu Pro Gln Asp Thr Tyr His Tyr Leu
             140                 145                 150

 ccc ttc agc ctg ccc cac cgg agg cct cac ttc ttc ttt ccc aag tcc      593
 Pro Phe Ser Leu Pro His Arg Arg Pro His Phe Phe Phe Pro Lys Ser
         155                 160                 165

 cgc atc gtc cgc agc ttg atg ccc ttc tct ccg tac gag ccc ctg aac      641
 Arg Ile Val Arg Ser Leu Met Pro Phe Ser Pro Tyr Glu Pro Leu Asn
     170                 175                 180

 ttc cac gcc atg ttc cag ccc ttc ctt gag atg ata cac gag gct cag      689
 Phe His Ala Met Phe Gln Pro Phe Leu Glu Met Ile His Glu Ala Gln
 185                 190                 195                 200

 cag gcc atg gac atc cac ttc cac agc ccg gcc ttc cag cac ccg cca      737
 Gln Ala Met Asp Ile His Phe His Ser Pro Ala Phe Gln His Pro Pro
                 205                 210                 215

 aca gaa ttc ata cga gaa ggc gac gat gac cgg act gtg tgc cgg gag      785
 Thr Glu Phe Ile Arg Glu Gly Asp Asp Asp Arg Thr Val Cys Arg Glu
             220                 225                 230

 atc cgc cac aac tcc acg ggc tgc ctg cgg atg aag gac cag tgt gac      833
 Ile Arg His Asn Ser Thr Gly Cys Leu Arg Met Lys Asp Gln Cys Asp
         235                 240                 245

 aag tgc cgg gag atc ttg tct gtg gac tgt tcc acc aac aac ccc tcc      881
 Lys Cys Arg Glu Ile Leu Ser Val Asp Cys Ser Thr Asn Asn Pro Ser
     250                 255                 260

 cag gct aag ctg cgg cgg gag ctc gac gaa tcc ctc cag gtc gct gag      929
 Gln Ala Lys Leu Arg Arg Glu Leu Asp Glu Ser Leu Gln Val Ala Glu
 265                 270                 275                 280

 agg ttg acc agg aaa tac aac gag ctg cta aag tcc tac cag tgg aag      977
 Arg Leu Thr Arg Lys Tyr Asn Glu Leu Leu Lys Ser Tyr Gln Trp Lys
                 285                 290                 295

 atg ctc aac acc tcc tcc ttg ctg gag cag ctg aac gag cag ttt aac     1025
 Met Leu Asn Thr Ser Ser Leu Leu Glu Gln Leu Asn Glu Gln Phe Asn
             300                 305                 310

 tgg gtg tcc cgg ctg gca aac ctc acg caa ggc gaa gac cag tac tat     1073
 Trp Val Ser Arg Leu Ala Asn Leu Thr Gln Gly Glu Asp Gln Tyr Tyr
         315                 320                 325

 ctg cgg gtc acc acg gtg gct tcc cac act tct gac tcg gac gtt cct     1121
 Leu Arg Val Thr Thr Val Ala Ser His Thr Ser Asp Ser Asp Val Pro
     330                 335                 340

 tcc ggt gtc act gag gtg gtc gtg aag ctc ttt gac tct gat ccc atc     1169
 Ser Gly Val Thr Glu Val Val Val Lys Leu Phe Asp Ser Asp Pro Ile
 345                 350                 355                 360

 act gtg acg gtc cct gta gaa gtc tcc agg aag aac cct aaa ttt atg     1217
 Thr Val Thr Val Pro Val Glu Val Ser Arg Lys Asn Pro Lys Phe Met
                 365                 370                 375

 gag acc gtg gcg gag aaa gcg ctg cag gaa tac cgc aaa aag cac cgg     1265
 Glu Thr Val Ala Glu Lys Ala Leu Gln Glu Tyr Arg Lys Lys His Arg
             380                 385                 390

 gag gag tga gatgtgg atgttgcttt tgcacctacg ggggcatctg agtccagctc     1321
 Glu Glu 


 cccccaagat gagctgcagc cccccagaga gagctctgca cgtcaccaag taaccaggcc   1381

 ccagcctcca ggcccccaac tccgcccagc ctctccccgc tctggatcct gcactctaac   1441

 actcgactct gctgctcatg ggaagaacag aattgctcct gcatgcaact aattcaataa   1501

 aactgtcttg tgagctgatc gcttggaggg tcctcttttt atgttgagtt gctgcttccc   1561

 ggcatgcctt cattttgcta tggggggcag gcagggggga tggaaaataa gtagaaacaa   1621

 aaaagcagtg gctaagatgg tatagggact gtcataccag tgaagaataa aagggtgaag   1681

 aataaaaggg atatgatgac aaggttgatc cacttcaaga attgcttgct ttcaggaaga   1741

 gagatgtgtt tcaacaagcc aactaaaata tattgctgca aatggaaaaa aaaaaa       1797




      <210> 356
      <211> 1336
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (22)..(1308)

      <400> 356
 gaattcgagc tcgccccggc c  atg tat tcc aat gtg ata gga act gta acc      51
                          Met Tyr Ser Asn Val Ile Gly Thr Val Thr
                            1               5                  10

 tct gga aaa agg aag gtt tat ctc ttg tcc ttg ctg ctc att ggc ttc       99
 Ser Gly Lys Arg Lys Val Tyr Leu Leu Ser Leu Leu Leu Ile Gly Phe
                  15                  20                  25

 tgg gac tgc gtg acc tgt cac ggg agc cct gtg gac atc tgc aca gcc      147
 Trp Asp Cys Val Thr Cys His Gly Ser Pro Val Asp Ile Cys Thr Ala
              30                  35                  40

 aag ccg cgg gac att ccc atg aat ccc atg tgc att tac cgc tcc ccg      195
 Lys Pro Arg Asp Ile Pro Met Asn Pro Met Cys Ile Tyr Arg Ser Pro
          45                  50                  55

 gag aag aag gca act gag gat gag ggc tca gaa cag aag atc ccg gag      243
 Glu Lys Lys Ala Thr Glu Asp Glu Gly Ser Glu Gln Lys Ile Pro Glu
      60                  65                  70

 gcc acc aac cgg cgt gtc tgg gaa ctg tcc aag gcc aat tcc cgc ttt      291
 Ala Thr Asn Arg Arg Val Trp Glu Leu Ser Lys Ala Asn Ser Arg Phe
  75                  80                  85                  90

 gct acc act ttc tat cag cac ctg gca gat tcc aag aat gac aat gat      339
 Ala Thr Thr Phe Tyr Gln His Leu Ala Asp Ser Lys Asn Asp Asn Asp
                  95                 100                 105

 aac att ttc ctg tca ccc ctg agt atc tcc acg gct ttt gct atg acc      387
 Asn Ile Phe Leu Ser Pro Leu Ser Ile Ser Thr Ala Phe Ala Met Thr
             110                 115                 120

 aag ctg ggt gcc tgt aat gac acc ctc cag caa ctg atg gag gta ttt      435
 Lys Leu Gly Ala Cys Asn Asp Thr Leu Gln Gln Leu Met Glu Val Phe
         125                 130                 135

 aag ttt gac acc ata tct gag aaa aca tct gat cag atc cac ttc ttc      483
 Lys Phe Asp Thr Ile Ser Glu Lys Thr Ser Asp Gln Ile His Phe Phe
     140                 145                 150

 ttt gcc aaa ctg aac tgc cga ctc tat cga tcc ctt acc ttc aat gag      531
 Phe Ala Lys Leu Asn Cys Arg Leu Tyr Arg Ser Leu Thr Phe Asn Glu
 155                 160                 165                 170

 acc tac cag gac atc agt gag ttg gta tat gga gcc aag ctc cag ccc      579
 Thr Tyr Gln Asp Ile Ser Glu Leu Val Tyr Gly Ala Lys Leu Gln Pro
                 175                 180                 185

 ctg gac ttc aag gaa ggc cga atc acc gat gtc att ccc tcg gaa gcc      627
 Leu Asp Phe Lys Glu Gly Arg Ile Thr Asp Val Ile Pro Ser Glu Ala
             190                 195                 200

 atc aat gag ctc act gtt ctg gtg ctg gtt aac acc att tac ttc aag      675
 Ile Asn Glu Leu Thr Val Leu Val Leu Val Asn Thr Ile Tyr Phe Lys
         205                 210                 215

 ggc ctg tgg aag tca aag ttc agc cct gag aac aca agg aag gaa ctg      723
 Gly Leu Trp Lys Ser Lys Phe Ser Pro Glu Asn Thr Arg Lys Glu Leu
     220                 225                 230

 ttc tac aag gct gat gga gag tcg tgt tca gca tct atg atg tac cag      771
 Phe Tyr Lys Ala Asp Gly Glu Ser Cys Ser Ala Ser Met Met Tyr Gln
 235                 240                 245                 250

 gaa ggc aag ttc cgt tat cgg cgc gtg gct gaa agc acc cag gtg ctt      819
 Glu Gly Lys Phe Arg Tyr Arg Arg Val Ala Glu Ser Thr Gln Val Leu
                 255                 260                 265

 gag ttg ccc ttc aaa ggt gat gac atc acc atg gtc ctc atc ttg ccc      867
 Glu Leu Pro Phe Lys Gly Asp Asp Ile Thr Met Val Leu Ile Leu Pro
             270                 275                 280

 aag cct gag aag agc cct gcc aag gtg gag aag gaa ctc acc cca gag      915
 Lys Pro Glu Lys Ser Pro Ala Lys Val Glu Lys Glu Leu Thr Pro Glu
         285                 290                 295

 gtg ctg cag gag tgg ctg gat gaa ttg gag gag atg atg ctg gtg gtc      963
 Val Leu Gln Glu Trp Leu Asp Glu Leu Glu Glu Met Met Leu Val Val
     300                 305                 310

 cac atg ccc cgc ttc cgc att gag gac ggc ttc agt ttg aag gag cag     1011
 His Met Pro Arg Phe Arg Ile Glu Asp Gly Phe Ser Leu Lys Glu Gln
 315                 320                 325                 330

 ctg caa gac atg ggc ctt gtc gat ctg ttc agc cct gaa aag tcc aaa     1059
 Leu Gln Asp Met Gly Leu Val Asp Leu Phe Ser Pro Glu Lys Ser Lys
                 335                 340                 345

 ctc cca ggt att gtt gca gaa ggc cga gat gac ctc tat gtc tca gat     1107
 Leu Pro Gly Ile Val Ala Glu Gly Arg Asp Asp Leu Tyr Val Ser Asp
             350                 355                 360

 gca ttc cat aag gca ttt ctt gag gta aat gaa gaa ggc agt gaa gca     1155
 Ala Phe His Lys Ala Phe Leu Glu Val Asn Glu Glu Gly Ser Glu Ala
         365                 370                 375

 gct gca agt acc gct gtt gtg att gct ggc cgt tcg cta aac ccc aac     1203
 Ala Ala Ser Thr Ala Val Val Ile Ala Gly Arg Ser Leu Asn Pro Asn
     380                 385                 390

 agg gtg act ttc aag gcc aac atg cct ttc ctg gtt ttt ata aga gaa     1251
 Arg Val Thr Phe Lys Ala Asn Met Pro Phe Leu Val Phe Ile Arg Glu
 395                 400                 405                 410

 gtt cct ctg aac act att atc ttc atg ggc agg gta gcc aac cct tgt     1299
 Val Pro Leu Asn Thr Ile Ile Phe Met Gly Arg Val Ala Asn Pro Cys
                 415                 420                 425

 gtt aag taa aatgttctct agaggatccc ccatcgat                          1336
 Val Lys 






      <210> 357
      <211> 1507
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (66)..(1460)

      <400> 357
 ctctggccca ccctgtcctc tggaacctct gcgagattta gaggaaagaa ccagttttca     60

 ggcgg    atg cct cag atc aca cta tct cca ctt gcc cag ccc tgt gga     107
          Met Pro Gln Ile Thr Leu Ser Pro Leu Ala Gln Pro Cys Gly
            1               5                  10

 aga tta gcg gcc atg tat tcc aat gtg ata gga act gta acc tct gga      155
 Arg Leu Ala Ala Met Tyr Ser Asn Val Ile Gly Thr Val Thr Ser Gly
  15                  20                  25                  30

 aaa agg aag gtt tat ctt ttg tcc ttg ctg ctc att ggc ttc tgg gac      203
 Lys Arg Lys Val Tyr Leu Leu Ser Leu Leu Leu Ile Gly Phe Trp Asp
                  35                  40                  45

 tgc gtg acc tgt cac ggg agc cct gtg gac atc tgc aca gcc aag ccg      251
 Cys Val Thr Cys His Gly Ser Pro Val Asp Ile Cys Thr Ala Lys Pro
              50                  55                  60

 cgg gac att ccc atg aat ccc atg tgc att tac cgc tcc ccg gag aag      299
 Arg Asp Ile Pro Met Asn Pro Met Cys Ile Tyr Arg Ser Pro Glu Lys
          65                  70                  75

 aag gca act gag gat gag ggc tca gaa cag aag atc ccg gag gcc acc      347
 Lys Ala Thr Glu Asp Glu Gly Ser Glu Gln Lys Ile Pro Glu Ala Thr
      80                  85                  90

 aac cgg cgt gtc tgg gaa ctg tcc aag gcc aat tcc cgc ttt gct acc      395
 Asn Arg Arg Val Trp Glu Leu Ser Lys Ala Asn Ser Arg Phe Ala Thr
  95                 100                 105                 110

 act ttc tat cag cac ctg gca gat tcc aag aat gac aat gat aac att      443
 Thr Phe Tyr Gln His Leu Ala Asp Ser Lys Asn Asp Asn Asp Asn Ile
                 115                 120                 125

 ttc ctg tca ccc ctg agt atc tcc acg gct ttt gct atg acc aag ctg      491
 Phe Leu Ser Pro Leu Ser Ile Ser Thr Ala Phe Ala Met Thr Lys Leu
             130                 135                 140

 ggt gcc tgt aat gac acc ctc cag caa ctg atg gag gta ttt aag ttt      539
 Gly Ala Cys Asn Asp Thr Leu Gln Gln Leu Met Glu Val Phe Lys Phe
         145                 150                 155

 gac acc ata tct gag aaa aca tct gat cag atc cac ttc ttc ttt gcc      587
 Asp Thr Ile Ser Glu Lys Thr Ser Asp Gln Ile His Phe Phe Phe Ala
     160                 165                 170

 aaa ctg aac tgc cga ctc tat cga tcc ctt acc ttc aat gag acc tac      635
 Lys Leu Asn Cys Arg Leu Tyr Arg Ser Leu Thr Phe Asn Glu Thr Tyr
 175                 180                 185                 190

 cag gac atc agt gag ttg gta tat gga gcc aag ctc cag ccc ctg gac      683
 Gln Asp Ile Ser Glu Leu Val Tyr Gly Ala Lys Leu Gln Pro Leu Asp
                 195                 200                 205

 ttc aag gaa aat gca gag caa tcc aga gcg gcc atc aac aaa tgg gtg      731
 Phe Lys Glu Asn Ala Glu Gln Ser Arg Ala Ala Ile Asn Lys Trp Val
             210                 215                 220

 tcc aat aag acc gaa ggc cga atc acc gat gtc att ccc tcg gaa gcc      779
 Ser Asn Lys Thr Glu Gly Arg Ile Thr Asp Val Ile Pro Ser Glu Ala
         225                 230                 235

 atc aat gag ctc act gtt ctg gtg ctg gtt aac acc att tac ttc aag      827
 Ile Asn Glu Leu Thr Val Leu Val Leu Val Asn Thr Ile Tyr Phe Lys
     240                 245                 250

 ggc ctg tgg aag tca aag ttc agc cct gag aac aca agg aag gaa ctg      875
 Gly Leu Trp Lys Ser Lys Phe Ser Pro Glu Asn Thr Arg Lys Glu Leu
 255                 260                 265                 270

 ttc tac aag gct gat gga gag tcg tgt tca gca tct atg atg tac cag      923
 Phe Tyr Lys Ala Asp Gly Glu Ser Cys Ser Ala Ser Met Met Tyr Gln
                 275                 280                 285

 gaa ggc aag ttc cgt tat cgg cgc gtg gct gaa ggc acc cag gtg ctt      971
 Glu Gly Lys Phe Arg Tyr Arg Arg Val Ala Glu Gly Thr Gln Val Leu
             290                 295                 300

 gag ttg ccc ttc aaa ggt gat gac atc acc atg gtc ctc atc ttg ccc     1019
 Glu Leu Pro Phe Lys Gly Asp Asp Ile Thr Met Val Leu Ile Leu Pro
         305                 310                 315

 aag cct gag aag agc ctg gcc aag gtg gag aag gaa ctc acc cca gag     1067
 Lys Pro Glu Lys Ser Leu Ala Lys Val Glu Lys Glu Leu Thr Pro Glu
     320                 325                 330

 gtg ctg cag gag tgg ctg gat gaa ttg gag gag atg atg ctg gtg gtc     1115
 Val Leu Gln Glu Trp Leu Asp Glu Leu Glu Glu Met Met Leu Val Val
 335                 340                 345                 350

 cac atg ccc cgc ttc cgc att gag gac ggc ttc agt ttg aag gag cag     1163
 His Met Pro Arg Phe Arg Ile Glu Asp Gly Phe Ser Leu Lys Glu Gln
                 355                 360                 365

 ctg caa gac atg ggc ctt gtc gat ctg ttc agc cct gaa aag tcc aaa     1211
 Leu Gln Asp Met Gly Leu Val Asp Leu Phe Ser Pro Glu Lys Ser Lys
             370                 375                 380

 ctc cca ggt att gtt gca gaa ggc cga gat gac ctc tat gtc tca gat     1259
 Leu Pro Gly Ile Val Ala Glu Gly Arg Asp Asp Leu Tyr Val Ser Asp
         385                 390                 395

 gca ttc cat aag gca ttt ctt gag gta aat gaa gaa ggc agt gaa gca     1307
 Ala Phe His Lys Ala Phe Leu Glu Val Asn Glu Glu Gly Ser Glu Ala
     400                 405                 410

 gct gca agt acc gct gtt gtg att gct ggc cgt tcg cta aac ccc aac     1355
 Ala Ala Ser Thr Ala Val Val Ile Ala Gly Arg Ser Leu Asn Pro Asn
 415                 420                 425                 430

 agg gtg act ttc aag gcc aac agg cct ttc ctg gtt ttt ata aga gaa     1403
 Arg Val Thr Phe Lys Ala Asn Arg Pro Phe Leu Val Phe Ile Arg Glu
                 435                 440                 445

 gtt cct ctg aac act att atc ttc atg ggc aga gta gcc aac cct tgt     1451
 Val Pro Leu Asn Thr Ile Ile Phe Met Gly Arg Val Ala Asn Pro Cys
             450                 455                 460

 gtt aag taa aatgttc ttattctttg cacctcttcc tatttttggt ttgtgaacag     1507
 Val Lys 






      <210> 358
      <211> 228
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (1)..(228)

      <400> 358
  atg gct tcc cat gct ttg aca aaa cct cgg atg cat ggc ctt ctg gcc      48
  Met Ala Ser His Ala Leu Thr Lys Pro Arg Met His Gly Leu Leu Ala
    1               5                  10                  15

 gag cat ctg caa ttt cat att gtt gga gta ttc atg gta tcc ctg gag       96
 Glu His Leu Gln Phe His Ile Val Gly Val Phe Met Val Ser Leu Glu
              20                  25                  30

 ctt gca gtt ttc tgt aag ttt gct gtg gct gaa cca aga aag aag gtg      144
 Leu Ala Val Phe Cys Lys Phe Ala Val Ala Glu Pro Arg Lys Lys Val
          35                  40                  45

 tac aca gat ttc ttc aga aat tat gat tcc atg aaa gat att gag gag      192
 Tyr Thr Asp Phe Phe Arg Asn Tyr Asp Ser Met Lys Asp Ile Glu Glu
      50                  55                  60

 atg agg aag gct ggt atc ttt cag agt aca aag tga                      228
 Met Arg Lys Ala Gly Ile Phe Gln Ser Thr Lys 
  65                  70                  75





      <210> 359
      <211> 405
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (1)..(405)

      <400> 359
  atg tgg ggg ccc tgt tcc ctg tct gtg cag cat ttg tgg ctc tgg cag      48
  Met Trp Gly Pro Cys Ser Leu Ser Val Gln His Leu Trp Leu Trp Gln
    1               5                  10                  15

 aca tgg tca gat gtt gaa ggc cag agg ccg gct ctg ctc atc tgc aca       96
 Thr Trp Ser Asp Val Glu Gly Gln Arg Pro Ala Leu Leu Ile Cys Thr
              20                  25                  30

 gct gca gca gga ccc acg cag gga gtt aag gct tac cca gat gcc aca      144
 Ala Ala Ala Gly Pro Thr Gln Gly Val Lys Ala Tyr Pro Asp Ala Thr
          35                  40                  45

 atg cac aga caa ctc ctg gct ccg gtg gaa gga agg atg gca gag aca      192
 Met His Arg Gln Leu Leu Ala Pro Val Glu Gly Arg Met Ala Glu Thr
      50                  55                  60

 ttg aat cag aaa ctc cat gtt gcc aat gtg ctg gaa gat gac ccc ggc      240
 Leu Asn Gln Lys Leu His Val Ala Asn Val Leu Glu Asp Asp Pro Gly
  65                  70                  75                  80

 tac cta cct cac gtc tac agc gag gaa ggg gag tgt gga ggg gcc cca      288
 Tyr Leu Pro His Val Tyr Ser Glu Glu Gly Glu Cys Gly Gly Ala Pro
                  85                  90                  95

 tcc ctc agc tct ctg gcc agc ttg gaa cag gag ttg caa cct gat ttg      336
 Ser Leu Ser Ser Leu Ala Ser Leu Glu Gln Glu Leu Gln Pro Asp Leu
             100                 105                 110

 ctg gac tct ttg ggt tca aaa gcg act ctg ttt gag gaa ata tat tca      384
 Leu Asp Ser Leu Gly Ser Lys Ala Thr Leu Phe Glu Glu Ile Tyr Ser
         115                 120                 125

 gag tca ggt gtt cct tcc taa                                          405
 Glu Ser Gly Val Pro Ser 
     130





      <210> 360
      <211> 1516
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (1)..(1380)

      <400> 360
  atg act ctg atg ttg cag agg agg caa ctg tgg ttc aaa agc cct ggg      48
  Met Thr Leu Met Leu Gln Arg Arg Gln Leu Trp Phe Lys Ser Pro Gly
    1               5                  10                  15

 ggt tgg ctc tgt ggg gat gct gca gga aga gtg tac ctg aag tgg aag       96
 Gly Trp Leu Cys Gly Asp Ala Ala Gly Arg Val Tyr Leu Lys Trp Lys
              20                  25                  30

 cac tgc gag acg cca ggc gtg aag acc ctg tgt aat ctg aag cac tgc      144
 His Cys Glu Thr Pro Gly Val Lys Thr Leu Cys Asn Leu Lys His Cys
          35                  40                  45

 gag acg cca gga gtg aag acc ctg tgt aat ctg aag aaa ctt ctg aat      192
 Glu Thr Pro Gly Val Lys Thr Leu Cys Asn Leu Lys Lys Leu Leu Asn
      50                  55                  60

 cgg ctt cag aaa gac cac cgg gag gac gtc tac ctc tac atc tct gga      240
 Arg Leu Gln Lys Asp His Arg Glu Asp Val Tyr Leu Tyr Ile Ser Gly
  65                  70                  75                  80

 cac ctg aac ccc aac aag ctc tac cag cct ccg gag acg atc tta cag      288
 His Leu Asn Pro Asn Lys Leu Tyr Gln Pro Pro Glu Thr Ile Leu Gln
                  85                  90                  95

 cac tgg ccc aat gcc cac cgg ccc aag ggg gag cgc gcc tct gag gtg      336
 His Trp Pro Asn Ala His Arg Pro Lys Gly Glu Arg Ala Ser Glu Val
             100                 105                 110

 gga gag ccg ccc gca ggg aag gtg gcg agg atg aag gag gcc ctg gcc      384
 Gly Glu Pro Pro Ala Gly Lys Val Ala Arg Met Lys Glu Ala Leu Ala
         115                 120                 125

 cac ttc acc atc cac acg gcc ctg gtc ccc agt gag gcc cag gac acc      432
 His Phe Thr Ile His Thr Ala Leu Val Pro Ser Glu Ala Gln Asp Thr
     130                 135                 140

 ccg ctg ttc agg tac ctg aac ccc cag gcc tct ctt tcc cac act tca      480
 Pro Leu Phe Arg Tyr Leu Asn Pro Gln Ala Ser Leu Ser His Thr Ser
 145                 150                 155                 160

 gag gag gat ttc ctt cca gtg gag gct gtc aga gag ggg aag gaa gaa      528
 Glu Glu Asp Phe Leu Pro Val Glu Ala Val Arg Glu Gly Lys Glu Glu
                 165                 170                 175

 aag aaa gga ggc cct cct gga cgg ggc cct cct gga tgg cgc agg agg      576
 Lys Lys Gly Gly Pro Pro Gly Arg Gly Pro Pro Gly Trp Arg Arg Arg
             180                 185                 190

 gaa gaa ctc cgg ctg ccc gac ttg aag gtg ctg tgc tac cag gag gcc      624
 Glu Glu Leu Arg Leu Pro Asp Leu Lys Val Leu Cys Tyr Gln Glu Ala
         195                 200                 205

 ggg tcc aga ggc acc agg gac cgg cac cac tat gtc agc tcc tac ctg      672
 Gly Ser Arg Gly Thr Arg Asp Arg His His Tyr Val Ser Ser Tyr Leu
     210                 215                 220

 gcc gga gcc acc agc gca gac agg tac agg atg ttc ctg cgt ttc cag      720
 Ala Gly Ala Thr Ser Ala Asp Arg Tyr Arg Met Phe Leu Arg Phe Gln
 225                 230                 235                 240

 aag gaa gtg ctc gcc aag caa gat ctc ctg aag aat gac ttc act ggg      768
 Lys Glu Val Leu Ala Lys Gln Asp Leu Leu Lys Asn Asp Phe Thr Gly
                 245                 250                 255

 agc aag gcg gcc gcg ggc cac gag aga aag ctg cag cag gag ctc cag      816
 Ser Lys Ala Ala Ala Gly His Glu Arg Lys Leu Gln Gln Glu Leu Gln
             260                 265                 270

 aaa atg tgc acg tgc agc ccc cag cag ttc aac aga ctg cac gtc ttt      864
 Lys Met Cys Thr Cys Ser Pro Gln Gln Phe Asn Arg Leu His Val Phe
         275                 280                 285

 gga aaa gtc ttt gaa gat att tgt aac agt tct ttg ata ttt ggt gat      912
 Gly Lys Val Phe Glu Asp Ile Cys Asn Ser Ser Leu Ile Phe Gly Asp
     290                 295                 300

 ctc ttg aaa aaa gtt aag gct ctt ctg gct caa ctc aag gcg ctg ggg      960
 Leu Leu Lys Lys Val Lys Ala Leu Leu Ala Gln Leu Lys Ala Leu Gly
 305                 310                 315                 320

 cag agg ccg gtg aag acg gcg gac atg gat ctc gcc agg gaa gag ctg     1008
 Gln Arg Pro Val Lys Thr Ala Asp Met Asp Leu Ala Arg Glu Glu Leu
                 325                 330                 335

 agg atg ctc gtg aca gcc aca aaa gca gcc ctg gag cag aat gat aga     1056
 Arg Met Leu Val Thr Ala Thr Lys Ala Ala Leu Glu Gln Asn Asp Arg
             340                 345                 350

 ctc aga agt gaa ctg gag atg gag gtg gca ttg ctg cag tct gca aag     1104
 Leu Arg Ser Glu Leu Glu Met Glu Val Ala Leu Leu Gln Ser Ala Lys
         355                 360                 365

 gaa cga tca gaa tca tct gag aaa cat ata att gat gaa aac cga ctt     1152
 Glu Arg Ser Glu Ser Ser Glu Lys His Ile Ile Asp Glu Asn Arg Leu
     370                 375                 380

 act ctt act gag aag gtt gaa aag aag agg tgt gaa ata ctc agt aag     1200
 Thr Leu Thr Glu Lys Val Glu Lys Lys Arg Cys Glu Ile Leu Ser Lys
 385                 390                 395                 400

 tgg gat gag ata caa gct ctg gaa aaa gaa att aaa aca act ttg gtt     1248
 Trp Asp Glu Ile Gln Ala Leu Glu Lys Glu Ile Lys Thr Thr Leu Val
                 405                 410                 415

 cat act gga att tca gat atc act gag aat agg att aaa agc ata gag     1296
 His Thr Gly Ile Ser Asp Ile Thr Glu Asn Arg Ile Lys Ser Ile Glu
             420                 425                 430

 cat gaa gct ata caa ttg gaa aca gaa aat atg att tta aag aag aat     1344
 His Glu Ala Ile Gln Leu Glu Thr Glu Asn Met Ile Leu Lys Lys Asn
         435                 440                 445

 ata aag tta ctg aaa aca tgt gag cag atc ata tga agac agtgagagag     1394
 Ile Lys Leu Leu Lys Thr Cys Glu Gln Ile Ile 
     450                 455

 cagacgcctt tggaattatc aaggatttgt aatcagagaa cagagatacg ctcagtgctg   1454

 acaatggcag tgaattctac ttctgatgtg catgatattg agatctatct tataagatca   1514

 tt                                                                  1516




      <210> 361
      <211> 1576
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (1)..(1440)

      <400> 361
  atg act ctg atg ttg cag agg agg caa ctg tgg ttc aaa agc cct ggg      48
  Met Thr Leu Met Leu Gln Arg Arg Gln Leu Trp Phe Lys Ser Pro Gly
    1               5                  10                  15

 ggt tgg ctc tgt ggg gat gct gca gga aga gtg tac ctg aag tgg aag       96
 Gly Trp Leu Cys Gly Asp Ala Ala Gly Arg Val Tyr Leu Lys Trp Lys
              20                  25                  30

 cac tgc gag acg cca ggc gtg aag acc ctg tgt aat ctg aag cac tgc      144
 His Cys Glu Thr Pro Gly Val Lys Thr Leu Cys Asn Leu Lys His Cys
          35                  40                  45

 gag acg cca gga gtg aag acc ctg tgt aat ctg aag aaa ctt ctg aat      192
 Glu Thr Pro Gly Val Lys Thr Leu Cys Asn Leu Lys Lys Leu Leu Asn
      50                  55                  60

 cgg ctt cag aaa gac cac cgg gag gac gtc tac ctc tac atc tct gga      240
 Arg Leu Gln Lys Asp His Arg Glu Asp Val Tyr Leu Tyr Ile Ser Gly
  65                  70                  75                  80

 cac ctg aac ccc aac aag ctc tac cag cct ccg gag acg atc tta cag      288
 His Leu Asn Pro Asn Lys Leu Tyr Gln Pro Pro Glu Thr Ile Leu Gln
                  85                  90                  95

 cac tgg ccc aat gcc cac cgg ccc aag ggg gag cgc gcc tct gag gtg      336
 His Trp Pro Asn Ala His Arg Pro Lys Gly Glu Arg Ala Ser Glu Val
             100                 105                 110

 gga gag ccg ccc gca ggg aag gtg gcg agg atg aag gag gcc ctg gcc      384
 Gly Glu Pro Pro Ala Gly Lys Val Ala Arg Met Lys Glu Ala Leu Ala
         115                 120                 125

 cac ttc acc atc cac acg gcc ctg gtc ccc agt gag gcc cag gac acc      432
 His Phe Thr Ile His Thr Ala Leu Val Pro Ser Glu Ala Gln Asp Thr
     130                 135                 140

 ccg ctg ttc agg tac ctg aac ccc cag gcc tct ctt tcc cac act tca      480
 Pro Leu Phe Arg Tyr Leu Asn Pro Gln Ala Ser Leu Ser His Thr Ser
 145                 150                 155                 160

 gag gag gat ttc ctt cca gtg gag gct gtc aga gag ggg aag gaa gaa      528
 Glu Glu Asp Phe Leu Pro Val Glu Ala Val Arg Glu Gly Lys Glu Glu
                 165                 170                 175

 aag aaa gga ggc cct cct gga cgg ggc cct cct gga tgg cgc agg agg      576
 Lys Lys Gly Gly Pro Pro Gly Arg Gly Pro Pro Gly Trp Arg Arg Arg
             180                 185                 190

 gaa gaa ctc cgg ctg ccc gac ttg aag gtg ctg tgc tac cag gag gcc      624
 Glu Glu Leu Arg Leu Pro Asp Leu Lys Val Leu Cys Tyr Gln Glu Ala
         195                 200                 205

 ggg tcc aga ggc acc agg gac cgg cac cac tat gtc agc tcc tac ctg      672
 Gly Ser Arg Gly Thr Arg Asp Arg His His Tyr Val Ser Ser Tyr Leu
     210                 215                 220

 gcc gga gcc acc agc gca gac agg tac agg atg ttc ctg cgt ttc cag      720
 Ala Gly Ala Thr Ser Ala Asp Arg Tyr Arg Met Phe Leu Arg Phe Gln
 225                 230                 235                 240

 aag gaa gtg ctc gcc aag caa gat ctc ctg aag aat gac ttc act ggg      768
 Lys Glu Val Leu Ala Lys Gln Asp Leu Leu Lys Asn Asp Phe Thr Gly
                 245                 250                 255

 agc aag gcg gcc gcg ggc cac gag aga aag ctg cag cag gag ctc cag      816
 Ser Lys Ala Ala Ala Gly His Glu Arg Lys Leu Gln Gln Glu Leu Gln
             260                 265                 270

 aaa atg tgc acg tgc agc ccc cag cag ttc aac aga ctg cac gtc ttt      864
 Lys Met Cys Thr Cys Ser Pro Gln Gln Phe Asn Arg Leu His Val Phe
         275                 280                 285

 gga aaa gtc ttt gaa gat att tgt aac agt tct ttg ata ttt ggt gat      912
 Gly Lys Val Phe Glu Asp Ile Cys Asn Ser Ser Leu Ile Phe Gly Asp
     290                 295                 300

 ctc ttg aaa aaa gtt aag gat gaa tat gaa ctc tac atg gca acg ctc      960
 Leu Leu Lys Lys Val Lys Asp Glu Tyr Glu Leu Tyr Met Ala Thr Leu
 305                 310                 315                 320

 ctg gag tcc cag cct gca gca cag tac gag gct ctt ctg gct caa ctc     1008
 Leu Glu Ser Gln Pro Ala Ala Gln Tyr Glu Ala Leu Leu Ala Gln Leu
                 325                 330                 335

 aag gcg ctg ggg cag agg ccg gtg aag acg gcg gac atg gat ctc gcc     1056
 Lys Ala Leu Gly Gln Arg Pro Val Lys Thr Ala Asp Met Asp Leu Ala
             340                 345                 350

 agg gaa gag ctg agg atg ctc gtg aca gcc aca aaa gca gcc ctg gag     1104
 Arg Glu Glu Leu Arg Met Leu Val Thr Ala Thr Lys Ala Ala Leu Glu
         355                 360                 365

 cag aat gat aga ctc aga agt gaa ctg gag atg gag gtg gca ttg ctg     1152
 Gln Asn Asp Arg Leu Arg Ser Glu Leu Glu Met Glu Val Ala Leu Leu
     370                 375                 380

 cag tct gca aag gaa cga tca gaa tca tct gag aaa cat ata att gat     1200
 Gln Ser Ala Lys Glu Arg Ser Glu Ser Ser Glu Lys His Ile Ile Asp
 385                 390                 395                 400

 gaa aac cga ctt act ctt act gag aag gtt gaa aag aag agg tgt gaa     1248
 Glu Asn Arg Leu Thr Leu Thr Glu Lys Val Glu Lys Lys Arg Cys Glu
                 405                 410                 415

 ata ctc agt aag tgg gat gag ata caa gct ctg gaa aaa gaa att aaa     1296
 Ile Leu Ser Lys Trp Asp Glu Ile Gln Ala Leu Glu Lys Glu Ile Lys
             420                 425                 430

 aca act ttg gtt cat act gga att tca gat atc act gag aat agg att     1344
 Thr Thr Leu Val His Thr Gly Ile Ser Asp Ile Thr Glu Asn Arg Ile
         435                 440                 445

 aaa agc ata gag cat gaa gct ata caa ttg gaa aca gaa aat atg att     1392
 Lys Ser Ile Glu His Glu Ala Ile Gln Leu Glu Thr Glu Asn Met Ile
     450                 455                 460

 tta aag aag aat ata aag tta ctg aaa aca tgt gag cag atc ata tga     1440
 Leu Lys Lys Asn Ile Lys Leu Leu Lys Thr Cys Glu Gln Ile Ile 
 465                 470                 475

 agacagtgag agagcagacg cctttggaat tatcaaggat ttgtaatcag agaacagaga   1500

 tacgctcagt gctgacaatg gcagtgaatt ctacttctga tgtgcatgat attgagatct   1560

 atcttataag atcatt                                                   1576




      <210> 362
      <211> 1342
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (130)..(975)

      <400> 362
 gctgcaggtt ggtggcggga ggaggggaca gctgcgggcg cggggagggg gcgccgcgcc     60

 gcgggggcca tggcggagcc aggaagccgg gagtccgaga cccgggcccg cagcccgagt    120

 gtcgccgcc    atg gct tcg ccg cag ctc tgc cgc gcg ctg gtg tcg gcg     168
              Met Ala Ser Pro Gln Leu Cys Arg Ala Leu Val Ser Ala
                1               5                  10

 caa tgg gtg gcg gag gcg ctg cgg gcc ccg cgc gct ggg cag cct ctg      216
 Gln Trp Val Ala Glu Ala Leu Arg Ala Pro Arg Ala Gly Gln Pro Leu
      15                  20                  25

 cag ctg ctg gac gcc tcc tgg tac ctg ccg aag ctg ggg cgc gac gcg      264
 Gln Leu Leu Asp Ala Ser Trp Tyr Leu Pro Lys Leu Gly Arg Asp Ala
  30                  35                  40                  45

 cga cgc gag ttc gag gag cgc cac atc ccg ggc gcc gct ttc ttc gac      312
 Arg Arg Glu Phe Glu Glu Arg His Ile Pro Gly Ala Ala Phe Phe Asp
                  50                  55                  60

 atc gac cag tgc agc gac cgc acc tcg ccc tac gac cac atg ctg ccc      360
 Ile Asp Gln Cys Ser Asp Arg Thr Ser Pro Tyr Asp His Met Leu Pro
              65                  70                  75

 ggg gcc gag cat ttc gcg gag tac gca ggc cgc ctg ggc gtg ggc gcg      408
 Gly Ala Glu His Phe Ala Glu Tyr Ala Gly Arg Leu Gly Val Gly Ala
          80                  85                  90

 gcc acc cac gtc gtg atc tac gac gcc agc gac cag ggc ctc tac tcc      456
 Ala Thr His Val Val Ile Tyr Asp Ala Ser Asp Gln Gly Leu Tyr Ser
      95                 100                 105

 gcc ccg cgc gtc tgg tgg atg ttc cgc gcc ttc ggc cac cac gcc gtg      504
 Ala Pro Arg Val Trp Trp Met Phe Arg Ala Phe Gly His His Ala Val
 110                 115                 120                 125

 tca ctg ctt gat ggc ggc ctc cgc cac tgg ctg cgc cag aac ctc ccg      552
 Ser Leu Leu Asp Gly Gly Leu Arg His Trp Leu Arg Gln Asn Leu Pro
                 130                 135                 140

 ctc agc tcc ggc aag agc caa cct gct ccc gcc gag ttc cgc gct cag      600
 Leu Ser Ser Gly Lys Ser Gln Pro Ala Pro Ala Glu Phe Arg Ala Gln
             145                 150                 155

 ctc gac ccc gcc ttc atc aag acc tac gag gac atc aag gag aac ctg      648
 Leu Asp Pro Ala Phe Ile Lys Thr Tyr Glu Asp Ile Lys Glu Asn Leu
         160                 165                 170

 gaa tcc cgg cgc ttc cag gtg gtg gac tcc cga gcc act ggc agg ttc      696
 Glu Ser Arg Arg Phe Gln Val Val Asp Ser Arg Ala Thr Gly Arg Phe
     175                 180                 185

 cgc ggc acc gag ccc gag ccc cga gac gac ttc ctg agc cag gag ggg      744
 Arg Gly Thr Glu Pro Glu Pro Arg Asp Asp Phe Leu Ser Gln Glu Gly
 190                 195                 200                 205

 ctg gag aag agc cct gag gag atc cgc cat ctg ttc cag gag aag aaa      792
 Leu Glu Lys Ser Pro Glu Glu Ile Arg His Leu Phe Gln Glu Lys Lys
                 210                 215                 220

 gtg gac ctg tct aag cca ctg gtg gcc acg tgt ggc tct ggc gtc aca      840
 Val Asp Leu Ser Lys Pro Leu Val Ala Thr Cys Gly Ser Gly Val Thr
             225                 230                 235

 gcc tgc cac gtg gca cta ggg gcc tac ctc tgc ggc aag cca gac gtg      888
 Ala Cys His Val Ala Leu Gly Ala Tyr Leu Cys Gly Lys Pro Asp Val
         240                 245                 250

 ccc atc tac gat ggc tcc tgg gtg gag tgg tac atg cgc gcc cgg ccc      936
 Pro Ile Tyr Asp Gly Ser Trp Val Glu Trp Tyr Met Arg Ala Arg Pro
     255                 260                 265

 gag gat gtc atc tca gag ggc cgg ggg aag acc cac tga agctgggcag       985
 Glu Asp Val Ile Ser Glu Gly Arg Gly Lys Thr His 
 270                 275                 280

 gacacaggcg agctcaggtg atgccggcca ccagcaatgc ctggcctggt agctccgctt   1045

 ctgctttcac caagagagtg tttcttcact caactcaggt ggcatttggg gtgacatctc   1105

 aaaggccagg aattccgttg acttgttggc tgccagtagg ggcgggagga aaggcggagg   1165

 cgagccctgg aggacggagg ccacaatccg agctggccac ctggtgctga gctggggccc   1225

 gctccattcg ggtatcttgc aggaataaat aaccagtgct ttacatacaa acaaatccgg   1285

 gctacatatc ggaggggaaa agagttaaat ggccgggcca acggtctgac ccattga      1342




      <210> 363
      <211> 2441
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (1227)..(2441)

      <400> 363
 aggctttctg cctctactag tgacagtcca agctaaagat taggttgcca agagacctgc     60

 aatgttgtgg aagcttaatg gagtcagagc aggttgtggg gtatatctga aggtggtctg    120

 ttgatgcttt gacctactgt caagggtgag gggtctctgg gcagggtggt gttgtcatgg    180

 gtatgcagct tatgtggtgc tcgtggctca cagttttttt gcccatcaga tagctgtggg    240

 gcctgcccag cttgttctcc ctcacccaag tttccttctg tttgcttcct gagtatctgg    300

 cccaaccagc tggttttgtc ccaagccttc tgtacccaga tcactgggct gttaggtgtc    360

 cagagctgtg gtgcttcttt gggcagaggc agtggctgtc agacaggcca cactctttct    420

 ggattatccc tgtagaggga ggcacaccag cttctgtacc agcccatcaa tccatgtctc    480

 actcttctca gtgttctgag agtgggggct cttcccctgc tgcagcacca gccacagatc    540

 tcagcttggc actcctgaac tatgtgctct aacccaacgg ggttgagatt gagcctgcag    600

 ctttatcttc tggcctcatg gggttggaga ctggttctgc ttggggagca gatatgctcg    660

 caaaccagta aagcactcat actgggcagt ggaagctctg ctgtgtgcat gttcttgtgg    720

 gagcagccag gtagcatcct tgggaggggc tggtggacag ccagctgtac agaagagaca    780

 caccttagtc tcatgagaaa ggcagcactg ctctctcctg gccctgcggt cagcagaggt    840

 cagagctatt tggaggaagg gggagagcct tggaggatgg gttcctgtgg ccatgttttg    900

 ctgtagctgc ctcacgtgca aaaccctctg gggtccatgc aggcaggagc tctctctgcc    960

 tactctcgag gcagatcccc ctgccaattc aagtatctat gggggttgtg ggatctcttg   1020

 taggtatgat cctagagatc cccagcaaga gtgaattgcc tcacagtcac ttcattcacc   1080

 ccttccctag ttgctattca gggccgggag ctagtcctaa catccagcaa gaccacatag   1140

 ggttgccagc ttcctcatct tcagcctctg tgtctgcatt gcctctctat caactctgag   1200

 tgttttctct cccagagatc tgtttg atg tat gtt ggc tta ctc aat att ttg    1253
                              Met Tyr Val Gly Leu Leu Asn Ile Leu
                                1               5

 gtc tct ctc agt ggg aaa gtt cct ttc tgg ctg tat ctg ggc agc cgt     1301
 Val Ser Leu Ser Gly Lys Val Pro Phe Trp Leu Tyr Leu Gly Ser Arg
  10                  15                  20                  25

 ctt gcc act ccc cca aca agt tct cag tta ttt ttc att ggt ggc aaa     1349
 Leu Ala Thr Pro Pro Thr Ser Ser Gln Leu Phe Phe Ile Gly Gly Lys
                  30                  35                  40

 gag agg agt cca gat gaa caa ggt gtg gat att ctt ata gtg ctc ata     1397
 Glu Arg Ser Pro Asp Glu Gln Gly Val Asp Ile Leu Ile Val Leu Ile
              45                  50                  55

 ttt cga tac cca tct act gat agt gct gaa caa atc aag aaa aaa att     1445
 Phe Arg Tyr Pro Ser Thr Asp Ser Ala Glu Gln Ile Lys Lys Lys Ile
          60                  65                  70

 gaa aag gct tta tat caa agt ttg aag acc aaa caa ttg tct ttg acc     1493
 Glu Lys Ala Leu Tyr Gln Ser Leu Lys Thr Lys Gln Leu Ser Leu Thr
      75                  80                  85

 ata aac aaa cca tca ttt aga ctc aca cgc tgt gga ata agg atg aca     1541
 Ile Asn Lys Pro Ser Phe Arg Leu Thr Arg Cys Gly Ile Arg Met Thr
  90                  95                 100                 105

 tct tca aac atg cca tta cca gca tcc tct tct act caa aga att gtc     1589
 Ser Ser Asn Met Pro Leu Pro Ala Ser Ser Ser Thr Gln Arg Ile Val
                 110                 115                 120

 caa gga agg gaa aca gct atg gaa ggg gaa tgg cca tgg cag gcc agc     1637
 Gln Gly Arg Glu Thr Ala Met Glu Gly Glu Trp Pro Trp Gln Ala Ser
             125                 130                 135

 ctc cag ctc ata ggg tca ggc cat cag tgt gga gcc agc ctc atc agt     1685
 Leu Gln Leu Ile Gly Ser Gly His Gln Cys Gly Ala Ser Leu Ile Ser
         140                 145                 150

 aac aca tgg ctg ctc aca gca gct cac tgc ttt tgg aaa aat aaa gac     1733
 Asn Thr Trp Leu Leu Thr Ala Ala His Cys Phe Trp Lys Asn Lys Asp
     155                 160                 165

 cca act caa tgg att gct act ttt ggt gca act ata aca cca ccc gca     1781
 Pro Thr Gln Trp Ile Ala Thr Phe Gly Ala Thr Ile Thr Pro Pro Ala
 170                 175                 180                 185

 gtg aaa cga aat gtg agg aaa att att ctt cat gag aat tac cat aga     1829
 Val Lys Arg Asn Val Arg Lys Ile Ile Leu His Glu Asn Tyr His Arg
                 190                 195                 200

 gaa aca aat gaa aat gac att gct ttg gtt cag ctc tct act gga gtt     1877
 Glu Thr Asn Glu Asn Asp Ile Ala Leu Val Gln Leu Ser Thr Gly Val
             205                 210                 215

 gag ttt tca aat ata gtc cag aga gtt tgc ctc cca gac tca tct ata     1925
 Glu Phe Ser Asn Ile Val Gln Arg Val Cys Leu Pro Asp Ser Ser Ile
         220                 225                 230

 aag ttg cca cct aaa aca agt gtg ttc gtc aca gga ttt gga tcc att     1973
 Lys Leu Pro Pro Lys Thr Ser Val Phe Val Thr Gly Phe Gly Ser Ile
     235                 240                 245

 gta gat gat gga cct ata caa aat aca ctt cgg caa gcc aga gtg gaa     2021
 Val Asp Asp Gly Pro Ile Gln Asn Thr Leu Arg Gln Ala Arg Val Glu
 250                 255                 260                 265

 acc ata agc act gat gtg tgt aac aga aag gat gtg tat gat ggc ctg     2069
 Thr Ile Ser Thr Asp Val Cys Asn Arg Lys Asp Val Tyr Asp Gly Leu
                 270                 275                 280

 ata act cca gga atg tta tgt gct gga ttc atg gaa gga aaa ata gat     2117
 Ile Thr Pro Gly Met Leu Cys Ala Gly Phe Met Glu Gly Lys Ile Asp
             285                 290                 295

 gca tgt aag gga gat tct ggt gga cct ctg gtt tat gat aat cat gac     2165
 Ala Cys Lys Gly Asp Ser Gly Gly Pro Leu Val Tyr Asp Asn His Asp
         300                 305                 310

 atc tgg tac att gta ggt ata gta agt tgg gga caa tca tgt gca ctt     2213
 Ile Trp Tyr Ile Val Gly Ile Val Ser Trp Gly Gln Ser Cys Ala Leu
     315                 320                 325

 ccc aaa aaa cct gga gtc tac acc aga gta act aag tat cga gat tgg     2261
 Pro Lys Lys Pro Gly Val Tyr Thr Arg Val Thr Lys Tyr Arg Asp Trp
 330                 335                 340                 345

 att gcc tca aag act ggc agc tcc tcc tta aga aca gac aca aat gaa     2309
 Ile Ala Ser Lys Thr Gly Ser Ser Ser Leu Arg Thr Asp Thr Asn Glu
                 350                 355                 360

 ttg cca ggc cag ata tca tca gca caa gta tca ttg cct gaa gaa aag     2357
 Leu Pro Gly Gln Ile Ser Ser Ala Gln Val Ser Leu Pro Glu Glu Lys
             365                 370                 375

 caa atc aag ggc cat aga atg ttt tat gaa aac ctc tgg tgt gtt aaa     2405
 Gln Ile Lys Gly His Arg Met Phe Tyr Glu Asn Leu Trp Cys Val Lys
         380                 385                 390

 agc ttg cct ctg aaa gag atg aat atc agg gcc tga                     2441
 Ser Leu Pro Leu Lys Glu Met Asn Ile Arg Ala 
     395                 400





      <210> 364
      <211> 1383
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (476)..(1279)

      <400> 364
 cttttttttt tttttttttt ttggcggtat aaaagtgctt ctttatttgg tcatacagct     60

 ttcaaatgtt gcttaacgaa cagatagcat ttttataatc agaggaaaga ctcagtatta    120

 aagtgcgcgt cccatcattg caaccgggcc ctcgggcagc cagctctctc ttgcttcgcg    180

 tccggctctc aggccctgga gctcggcctc cctaccttct ccaggcgcgg gtcctgctcc    240

 ttttccggcc gccctcgctc cgccccttcg cctctccccg tgatccctct ctcgctaacc    300

 gtaggcgctt ttcgtgaagg cccgggtttt tacagcactt cgcttttcta accacgaaca    360

 gtgctcgttc gttcgcaggg ccagcaagga gagccccgcc cccgcccgcc gcccgccgcc    420

 cgccgcccgc cgcctttgga tcccgcggac tccgcccggc ccggcctccc caggc atg     478
                                                              Met
                                                                1

 gcg ccg ctg cgc ttc tcc gcc aat ctg tcc tgg cta ttc ccc gag ctc      526
 Ala Pro Leu Arg Phe Ser Ala Asn Leu Ser Trp Leu Phe Pro Glu Leu
               5                  10                  15

 ccc ggc ctc ccc gcg cgg gtg cgg gcc gcg ggc agc tcg ggc ttc gag      574
 Pro Gly Leu Pro Ala Arg Val Arg Ala Ala Gly Ser Ser Gly Phe Glu
          20                  25                  30

 gcc gtc gag gtg gcc tgg ccg tac gcg gag acg cct gag gcg ctg gcg      622
 Ala Val Glu Val Ala Trp Pro Tyr Ala Glu Thr Pro Glu Ala Leu Ala
      35                  40                  45

 cgc gcc gcg cga gaa gcg ggg ctg cgg ctt gta ctg atc aac acg ccc      670
 Arg Ala Ala Arg Glu Ala Gly Leu Arg Leu Val Leu Ile Asn Thr Pro
  50                  55                  60                  65

 ccg gga gac caa gag aag ggg gaa atg ggg ctg ggg gcc gtc ccc gga      718
 Pro Gly Asp Gln Glu Lys Gly Glu Met Gly Leu Gly Ala Val Pro Gly
                  70                  75                  80

 aga cag gcg gcc ttc cga gag gga ctg gag cag gcc gtg cgg tat gcc      766
 Arg Gln Ala Ala Phe Arg Glu Gly Leu Glu Gln Ala Val Arg Tyr Ala
              85                  90                  95

 aaa gcc ctg ggc tgt ccc agg atc cac ctg atg gct ggc cga gta ccc      814
 Lys Ala Leu Gly Cys Pro Arg Ile His Leu Met Ala Gly Arg Val Pro
         100                 105                 110

 cag gga gct gat cga ata gca gtc aag gct gag atg gag gcc gtt ttt      862
 Gln Gly Ala Asp Arg Ile Ala Val Lys Ala Glu Met Glu Ala Val Phe
     115                 120                 125

 ctg gag aac ctg agg cat gca gct ggg gtt ttg gct cag gag gac ctc      910
 Leu Glu Asn Leu Arg His Ala Ala Gly Val Leu Ala Gln Glu Asp Leu
 130                 135                 140                 145

 gtg gga ctg ctg gag ccc atc aac acc cgc atc act gac ccc cag tac      958
 Val Gly Leu Leu Glu Pro Ile Asn Thr Arg Ile Thr Asp Pro Gln Tyr
                 150                 155                 160

 ttc ctg gac acg ccc cag cag gtg gca gcc atc tta cag aag gac ata     1006
 Phe Leu Asp Thr Pro Gln Gln Val Ala Ala Ile Leu Gln Lys Asp Ile
             165                 170                 175

 ttc cac tgg cag atc atg gat ggg aac ctg aca gga aac atc cgg gag     1054
 Phe His Trp Gln Ile Met Asp Gly Asn Leu Thr Gly Asn Ile Arg Glu
         180                 185                 190

 ttc ctg ccc att gtt ggg cat gtg cag gtg gca cag gtc cca ggc cga     1102
 Phe Leu Pro Ile Val Gly His Val Gln Val Ala Gln Val Pro Gly Arg
     195                 200                 205

 ggg gag ccc agc agc ccc gga gag ctg aat ttc ccc tat ctg ttt caa     1150
 Gly Glu Pro Ser Ser Pro Gly Glu Leu Asn Phe Pro Tyr Leu Phe Gln
 210                 215                 220                 225

 ctg ctg gaa gat gaa ggc tac aaa ggc ttc gtg ggc tgt gag tat cag     1198
 Leu Leu Glu Asp Glu Gly Tyr Lys Gly Phe Val Gly Cys Glu Tyr Gln
                 230                 235                 240

 cct cga gga gac aca gta gag ggc ttg agt tgg cta cgt tca tac tgg     1246
 Pro Arg Gly Asp Thr Val Glu Gly Leu Ser Trp Leu Arg Ser Tyr Trp
             245                 250                 255

 gat agg cgg ggc cac cca gag gct ggc cag tga gggcccgc acaccaccca     1297
 Asp Arg Arg Gly His Pro Glu Ala Gly Gln 
         260                 265

 cgtgcctcca gacagcgagt gacatcccat ctcctcctct gcattaaaga tgacctgctg   1357

 aacataaaaa aaaaaaaaaa aaaacg                                        1383




      <210> 365
      <211> 1463
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (224)..(370)

      <400> 365
 ccgagacccc gattcctgaa tcctgaaggt gattggtcgc gggaggaggg gcaggcggga     60

 ggagcgggtc ccgcggcggg gcttgcagga atcgctggct ccggctgcca cctatcggac    120

 gggagccgct cccgggcggc acacagccga gtccctcctc ccctccccgc aggcagcctg    180

 tgccttttct ccaaacgaag acagcacttt gaaaattctt tca  atg gat ttt ttt     235
                                                  Met Asp Phe Phe
                                                    1

 ttc ctt gaa aga tcg tac tgg ggg aaa atg ata ctt cta tta gtt aca      283
 Phe Leu Glu Arg Ser Tyr Trp Gly Lys Met Ile Leu Leu Leu Val Thr
   5                  10                  15                  20

 tat tct cca atc gca tac tcg cac ccc cct cgt ttt gag atc gct ccc      331
 Tyr Ser Pro Ile Ala Tyr Ser His Pro Pro Arg Phe Glu Ile Ala Pro
                  25                  30                  35

 cta ggc agg ctc agg cgg gcg cgg agc cgc gcg gag tga caaagccgcc       380
 Leu Gly Arg Leu Arg Arg Ala Arg Ser Arg Ala Glu 
              40                  45

 gctgccgccg ccgggggtgg gagccgcgct cgcccgccgc ccctcgactc gcgagggcgt    440

 aaaagtttgt ctcagctcga gcattcctag cgccaacacg ccctcaggta aaggtggaag    500

 taaatggcca cgctgtattg acagaggtag ggtttgtttt ttaatactcg ttctcacttt    560

 aagtctcacc agggaggggt ttgggaagca ctgcgtgttt gggggacgtt ttgcgcttcc    620

 tggtctctcc agtctacaag tcgggagtcg gcgaccgctt agtgacgagc gatgatttta    680

 aagagcagaa taaaaggttt tcccgtgcct gccccacagc ccctccagct cgaataatgg    740

 agaactgtca atgcactccg cgagcggtgg cccattgtac gcagctgatg gcgaggaggc    800

 gactgggggt agcaggggct ccttgccctc gtccctatgc ccaaataaac gcgcaaacgc    860

 gctcccgtct tctggtcagt taaaaggtga aacgaacacg attaaaatag accaaaagaa    920

 aagaaagaaa agaaaacctt tctatgtaca gattctaaat cgtactcccc atacagtcag    980

 aggcagggag tcgagggcag aggcagcagg cggagagagg gagatagggc gagggaagga   1040

 gaacgcggag agagacgaag ggagtgggag accagcgaca gcgagcgcca gggcaccgca   1100

 ggcacactgg atgcccagtc cgccggccca gccgccctcg gaccctggac cgtgcgtcgt   1160

 gggcaccaga aacgagactc ggccaaatcc tgcctcacca gcaggtagat gaaactcaag   1220

 agaaaaggtg tggataaatg aaactagccc atgatgaacc tgttttctcc gtgaccacaa   1280

 tattaaccag gatgaatggc ggtggcagtg ggcctgcatc acaggttgca gcagatgttc   1340

 tcaatatttc tattaaaatt tccttatttc catatgcaag aggagcccca gagctgcatc   1400

 cttatggtag ctaccatgcc gagatgtaag ctgccattca ctggggagct ttggcaatag   1460

 aat                                                                 1463




      <210> 366
      <211> 686
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (366)..(638)

      <400> 366
 ttctaggacc accggcatca cttgggggct tgttttagat gcagagtctc aggccccacc     60

 ccagaccgga atcacacact gcatttcaac aaggcccaca ggtgactgca gcgtgtgtta    120

 aagtatgaga aatgccacca gggaggagag gcccacacca gtccagagac tagtgattca    180

 gagcatcact acccaagaga actttacgca gtgatgcaaa tgttccgtct gtctctgtgc    240

 tggccagaat taaccgctag tcacatgggg cctttgaaca taaatgtggc tagcacaact    300

 cagaaactga atattaaatg tagtaagatt tcgttcattt caatttaaag agccacgtgt    360

 ggcta    atg gta aca ata ctg gac aga gtt cta gtt cta gag tgc ggc     407
          Met Val Thr Ile Leu Asp Arg Val Leu Val Leu Glu Cys Gly
            1               5                  10

 ttt tct gtt gcc cca aac ttt tca gtg cac ctg agc tgc aat ggg ctg      455
 Phe Ser Val Ala Pro Asn Phe Ser Val His Leu Ser Cys Asn Gly Leu
  15                  20                  25                  30

 gga agt acc ctc act gaa cct ctg cat att ttt tcc agg cat cct gta      503
 Gly Ser Thr Leu Thr Glu Pro Leu His Ile Phe Ser Arg His Pro Val
                  35                  40                  45

 cac gtc aaa gaa gag ccc ctc gat cca gag gaa gct gaa ggg ccc ctg      551
 His Val Lys Glu Glu Pro Leu Asp Pro Glu Glu Ala Glu Gly Pro Leu
              50                  55                  60

 tcc tta gtg aca aca gcc aac cac agt cca gat ttt gac cat gac aga      599
 Ser Leu Val Thr Thr Ala Asn His Ser Pro Asp Phe Asp His Asp Arg
          65                  70                  75

 gat tac gaa gat gaa cca gta aac gag gac atg gag tga ctatcggggc       648
 Asp Tyr Glu Asp Glu Pro Val Asn Glu Asp Met Glu 
      80                  85                  90

 gggccaaccc cgagaatgaa gattggaaaa aaaaaaaa                            686




      <210> 367
      <211> 472
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (219)..(410)

      <400> 367
 taggatttgg aatgggattt ctttgaatcc ataaatcaat cggaaagaat tgatgttctt     60

 ttttgtttgc cttttgtgtg tcgattttgt atcttgcaac tgtactacat ttgtttacca    120

 gctctaatag tttttcagtg gaatctttat gtttttccaa atataagttt atatcatcag    180

 taaacaagga taattggact tctttctttc caatctgg    atg act ttt att tct     233
                                              Met Thr Phe Ile Ser
                                                1               5

 ttc tct tca ctg att gca cta tct aaa act tcc agc act atg gca tgg      281
 Phe Ser Ser Leu Ile Ala Leu Ser Lys Thr Ser Ser Thr Met Ala Trp
                  10                  15                  20

 ccc aag att cca ttc ctt gga atc cgt gag gcc aag aac ccc agg tca      329
 Pro Lys Ile Pro Phe Leu Gly Ile Arg Glu Ala Lys Asn Pro Arg Ser
              25                  30                  35

 gag aac aca agg ctt gcc acc atc ttg gaa gcc gcc cac cac cat ctt      377
 Glu Asn Thr Arg Leu Ala Thr Ile Leu Glu Ala Ala His His His Leu
          40                  45                  50

 gga agc agc cca cca cca tcc tgg gag ctc taa gaacgagg acaccccggt      428
 Gly Ser Ser Pro Pro Pro Ser Trp Glu Leu 
      55                  60

 aacagcagca tgggctgaag caaaggagtc agccatccac acgg                     472




      <210> 368
      <211> 989
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (306)..(989)

      <400> 368
 ccacctacaa cagaaccctc attggctgcc agacccactc aggggagaag attctggaga     60

 atgggctggt ggaaggccat gcctatactc tcacaggaat caggaaggtg acctgcaaac    120

 atagacctga atatctcgtc aagctacgga acccctgggg aaaggtggaa tggaaaggag    180

 actggagtga caggtgaact ttggggacat cttggagggg tgagaacagt tcaagtaaat    240

 gggagctgct gagccccaag gagaagattc tgcttctgag gaaagacaat gacggagaat    300

 tctgg    atg acg ctg cag gac ttt aaa aca cat ttc gtg ctc ctg gtt     347
          Met Thr Leu Gln Asp Phe Lys Thr His Phe Val Leu Leu Val
            1               5                  10

 atc tgt aaa ctg acc cca ggc ctg ttg agc cag gag gcg gcc cag aag      395
 Ile Cys Lys Leu Thr Pro Gly Leu Leu Ser Gln Glu Ala Ala Gln Lys
  15                  20                  25                  30

 tgg acg tac acc atg cgg gag ggg aga tgg gag aag cgg agc aca gct      443
 Trp Thr Tyr Thr Met Arg Glu Gly Arg Trp Glu Lys Arg Ser Thr Ala
                  35                  40                  45

 ggt ggc cag agg cag ttg ctg cag gac aca ttt tgg aag aac ccg cag      491
 Gly Gly Gln Arg Gln Leu Leu Gln Asp Thr Phe Trp Lys Asn Pro Gln
              50                  55                  60

 ttc ctg ctg tct gtc tgg agg ccc gag gag ggc agg aga tcc ctg agg      539
 Phe Leu Leu Ser Val Trp Arg Pro Glu Glu Gly Arg Arg Ser Leu Arg
          65                  70                  75

 ccc tgc agc gtg ctg gtg tcc ctg ctc cag aag ccc agg cac agg tgc      587
 Pro Cys Ser Val Leu Val Ser Leu Leu Gln Lys Pro Arg His Arg Cys
      80                  85                  90

 cgc aag cgg aag cct ctc ctc gcc att ggc ttc tac ctc tat agg tac      635
 Arg Lys Arg Lys Pro Leu Leu Ala Ile Gly Phe Tyr Leu Tyr Arg Tyr
  95                 100                 105                 110

 cat gat gac cag agg aga ctg ccc cct gag ttc ttc cag aga aac act      683
 His Asp Asp Gln Arg Arg Leu Pro Pro Glu Phe Phe Gln Arg Asn Thr
                 115                 120                 125

 cct ctg agc cag cct gat agg ttt ctc aag gag aaa gaa gtg agt cag      731
 Pro Leu Ser Gln Pro Asp Arg Phe Leu Lys Glu Lys Glu Val Ser Gln
             130                 135                 140

 gag ctg tgt ctg gaa cca ggg acg tac ctc atc gtg ccc tgc ata ttg      779
 Glu Leu Cys Leu Glu Pro Gly Thr Tyr Leu Ile Val Pro Cys Ile Leu
         145                 150                 155

 gag gcc cac cag aag tca gag ttc gtc ctc agg gtc ttc tcc agg aag      827
 Glu Ala His Gln Lys Ser Glu Phe Val Leu Arg Val Phe Ser Arg Lys
     160                 165                 170

 cac atc ttt tat gaa att ggc agc aat tct ggt gtc gtc ttc tca aag      875
 His Ile Phe Tyr Glu Ile Gly Ser Asn Ser Gly Val Val Phe Ser Lys
 175                 180                 185                 190

 gag ata gaa gac caa aat gaa agg cag gat gaa ttc ttc acc aaa ttc      923
 Glu Ile Glu Asp Gln Asn Glu Arg Gln Asp Glu Phe Phe Thr Lys Phe
                 195                 200                 205

 ttt gaa aag atc tgc ttc ctc acc cct cgt ttc tgc tcc cat aac ttc      971
 Phe Glu Lys Ile Cys Phe Leu Thr Pro Arg Phe Cys Ser His Asn Phe
             210                 215                 220

 agc ttg ggc ttg cct tag                                              989
 Ser Leu Gly Leu Pro 
         225





      <210> 369
      <211> 821
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (309)..(821)

      <400> 369
 aaaaattgca gctgccttct ccccaagata gttttcagtt ccagacaaaa ccatccagaa     60

 ctcaggaggc cttctcaagt gaatgctgca gaacagagga agagttccta gatcaagtga    120

 agaggaagct ggctcagacc agccctgaga aagacctgtt gaccacaaag ccttgtcact    180

 gtaaggatat cctgaagtta gtgctcttac ccctcaccca gcattgcttg gtcgttggag    240

 aaaccacctg tgcattttat tacctgctgg aggctgcggc tgcctgcttg gacctgtcag    300

 ataattat atg gtc tgt ttc aac atg gga cgt atc act tta gcc aaa aaa     350
          Met Val Cys Phe Asn Met Gly Arg Ile Thr Leu Ala Lys Lys
            1               5                  10

 ttg gct agg aaa gcc ctt cga ctg ctg aaa agg aat ttc cct tgg acc      398
 Leu Ala Arg Lys Ala Leu Arg Leu Leu Lys Arg Asn Phe Pro Trp Thr
  15                  20                  25                  30

 tgg ttt ggt gtc ctt ttc cag aca ttc ctg gaa aag tat tgg cat tcc      446
 Trp Phe Gly Val Leu Phe Gln Thr Phe Leu Glu Lys Tyr Trp His Ser
                  35                  40                  45

 tgt acc ctg agc caa cct cca aac gac cct agt gag aat aag aag aat      494
 Cys Thr Leu Ser Gln Pro Pro Asn Asp Pro Ser Glu Asn Lys Lys Asn
              50                  55                  60

 ttg gca gtc ctg cag cag cag gtg cat tgc ctc tcc cta ctc tgg cag      542
 Leu Ala Val Leu Gln Gln Gln Val His Cys Leu Ser Leu Leu Trp Gln
          65                  70                  75

 ctc tat aac ctg gag gcc aca gcc agt agc tac agg ttt gcc tgc ctg      590
 Leu Tyr Asn Leu Glu Ala Thr Ala Ser Ser Tyr Arg Phe Ala Cys Leu
      80                  85                  90

 gct act ctt atg cag aag aat tca gct gat gag ttt gca aat gaa gcc      638
 Ala Thr Leu Met Gln Lys Asn Ser Ala Asp Glu Phe Ala Asn Glu Ala
  95                 100                 105                 110

 cag agt gtg ggc atc aag gac aag tgg ctg cac tgt gag cag atg gcc      686
 Gln Ser Val Gly Ile Lys Asp Lys Trp Leu His Cys Glu Gln Met Ala
                 115                 120                 125

 att cag aaa agc agt tta tgt tgg ttc tcc agg gag ggg ttg ttg gcc      734
 Ile Gln Lys Ser Ser Leu Cys Trp Phe Ser Arg Glu Gly Leu Leu Ala
             130                 135                 140

 aca gct cag ctc atg cag gcc ctg gcc tac acc aag ctc tgc ctt ggt      782
 Thr Ala Gln Leu Met Gln Ala Leu Ala Tyr Thr Lys Leu Cys Leu Gly
         145                 150                 155

 cat ctt gac ttc tcc atc aag ctg ggt aat ggg act tag                  821
 His Leu Asp Phe Ser Ile Lys Leu Gly Asn Gly Thr 
     160                 165                 170





      <210> 370
      <211> 1116
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (1)..(1116)

      <400> 370
  atg gat gct gct gct cat ctg gga atc act tta ata acc act ata ctc      48
  Met Asp Ala Ala Ala His Leu Gly Ile Thr Leu Ile Thr Thr Ile Leu
    1               5                  10                  15

 ccg tat gtc atg atg aac cat gaa atg ttt tac att agg aga aag gtt       96
 Pro Tyr Val Met Met Asn His Glu Met Phe Tyr Ile Arg Arg Lys Val
              20                  25                  30

 cag acc caa gag aaa gct gtg gga aaa act ggc aca cgc atg aaa gag      144
 Gln Thr Gln Glu Lys Ala Val Gly Lys Thr Gly Thr Arg Met Lys Glu
          35                  40                  45

 agg acc ttg gta aaa gag ttt atg cca caa tta agt gtg aca gag aat      192
 Arg Thr Leu Val Lys Glu Phe Met Pro Gln Leu Ser Val Thr Glu Asn
      50                  55                  60

 gtg atc caa ggg att cca ata gtt aaa atg gca caa gaa gca aaa gga      240
 Val Ile Gln Gly Ile Pro Ile Val Lys Met Ala Gln Glu Ala Lys Gly
  65                  70                  75                  80

 gcc aac aag aac aga aat aca gaa gca agc acc aca gga agc aag aga      288
 Ala Asn Lys Asn Arg Asn Thr Glu Ala Ser Thr Thr Gly Ser Lys Arg
                  85                  90                  95

 aga caa cta ctc aag aaa ttg gaa atg gtt cct ggt atc aaa tcc tgc      336
 Arg Gln Leu Leu Lys Lys Leu Glu Met Val Pro Gly Ile Lys Ser Cys
             100                 105                 110

 agg gta aca gca ttc att cct act caa gat gtg aat gat cat tgg gca      384
 Arg Val Thr Ala Phe Ile Pro Thr Gln Asp Val Asn Asp His Trp Ala
         115                 120                 125

 cat cca tcc tca gat gct gat gaa atg cgg agt gca tat cca gaa cat      432
 His Pro Ser Ser Asp Ala Asp Glu Met Arg Ser Ala Tyr Pro Glu His
     130                 135                 140

 gct ggg ggt cac tcg ggc atg ccc tca cat ctt atg tct gtt ggg ccc      480
 Ala Gly Gly His Ser Gly Met Pro Ser His Leu Met Ser Val Gly Pro
 145                 150                 155                 160

 aac cag cta acc cat tct ttt atc ttt aat att tta gat gct gag agt      528
 Asn Gln Leu Thr His Ser Phe Ile Phe Asn Ile Leu Asp Ala Glu Ser
                 165                 170                 175

 gtc att tgt cat cag acc tgg aat act aaa agc atg cct cca atg gag      576
 Val Ile Cys His Gln Thr Trp Asn Thr Lys Ser Met Pro Pro Met Glu
             180                 185                 190

 aac aca agg cag agc act gct gac acc cct aca caa att aat gtc ccc      624
 Asn Thr Arg Gln Ser Thr Ala Asp Thr Pro Thr Gln Ile Asn Val Pro
         195                 200                 205

 atc tct act gat aca tct gat agg tac aaa cga tgt gtc cgt gat gac      672
 Ile Ser Thr Asp Thr Ser Asp Arg Tyr Lys Arg Cys Val Arg Asp Asp
     210                 215                 220

 tgg ggc aac tat gag aca cag aaa gat aac tta gac aca gag cac aag      720
 Trp Gly Asn Tyr Glu Thr Gln Lys Asp Asn Leu Asp Thr Glu His Lys
 225                 230                 235                 240

 aaa tgc acc ttg ctg act aca gaa tcc gag aag aat ggg aag ggg aaa      768
 Lys Cys Thr Leu Leu Thr Thr Glu Ser Glu Lys Asn Gly Lys Gly Lys
                 245                 250                 255

 aga tgt tct gat gat agg acc ttg agg gag gac tgg ctg ccc ctg agg      816
 Arg Cys Ser Asp Asp Arg Thr Leu Arg Glu Asp Trp Leu Pro Leu Arg
             260                 265                 270

 ggc agg agg ttg aca gga tct aaa cat aga gtt agt cat cca gtc ttt      864
 Gly Arg Arg Leu Thr Gly Ser Lys His Arg Val Ser His Pro Val Phe
         275                 280                 285

 cag aat cca ctt cct gag cgt ctc ccc ttc att ctc acg gtc acc agc      912
 Gln Asn Pro Leu Pro Glu Arg Leu Pro Phe Ile Leu Thr Val Thr Ser
     290                 295                 300

 ctg ctt gtg gca tca tca cca tct gcc cca gaa gcc cgt gat gct tgc      960
 Leu Leu Val Ala Ser Ser Pro Ser Ala Pro Glu Ala Arg Asp Ala Cys
 305                 310                 315                 320

 tct aac tca gat cct gga atc ctt ttt gca caa ctc cag ttc aat ccc     1008
 Ser Asn Ser Asp Pro Gly Ile Leu Phe Ala Gln Leu Gln Phe Asn Pro
                 325                 330                 335

 tca ttg cta gga atc ttt cct aca ggc aaa tgt gat ctt att gtc ctg     1056
 Ser Leu Leu Gly Ile Phe Pro Thr Gly Lys Cys Asp Leu Ile Val Leu
             340                 345                 350

 tac aaa acc ctt cag tgg cac ctc cta ccc tca gag tac att tcc tgt     1104
 Tyr Lys Thr Leu Gln Trp His Leu Leu Pro Ser Glu Tyr Ile Ser Cys
         355                 360                 365

 ttg cca ctc taa                                                     1116
 Leu Pro Leu 
     370





      <210> 371
      <211> 372
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (143)..(322)

      <400> 371
 tctccccacc cttaaagtgg gtcacaggac cctcttgtga gaggcaccct cgtctccaaa     60

 gacggaggga gccgggagca gacagcacac aggccttgcc gtggttccca ccgaccaccc    120

 tcagctcacc ccttgtcctg tc atg ctt ccc cac gac ctc tgt gtc ctc atc     172
                          Met Leu Pro His Asp Leu Cys Val Leu Ile
                            1               5                  10

 caa cct agc ata gaa agc gct cag gcg tta ctg tct ttt cgg gtc tcc      220
 Gln Pro Ser Ile Glu Ser Ala Gln Ala Leu Leu Ser Phe Arg Val Ser
                  15                  20                  25

 gct gcc cct tcg ggt cgc cgc tgc ctc ttc ggg tct gca cta tct ctt      268
 Ala Ala Pro Ser Gly Arg Arg Cys Leu Phe Gly Ser Ala Leu Ser Leu
              30                  35                  40

 ccg gtc tgc gct gcc tta gga agg ctt cca tac cac atg gga ctt act      316
 Pro Val Cys Ala Ala Leu Gly Arg Leu Pro Tyr His Met Gly Leu Thr
          45                  50                  55

 aag taa atccgtgtaa ttttctcgtt aagcttaact tacagggctc cagctgaaga       372
 Lys 






      <210> 372
      <211> 1403
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (591)..(914)

      <400> 372
 ctcgtagaca ctagtccatg tggtggaatt cgaatgtggc tcaagttcgg gaggcgttac     60

 ctgcggaggg tttgaggcag gcccaggagc gagcccatgg tcttccgccg cggggccagg    120

 ggcgggcccc aggatccgga gcttcgtgcg gggccgagtc caggtttggg gcccgggagg    180

 cggggccagt tagggcgagg gtccctggga tcgtcgggtc aggccttggg ctaacgtagg    240

 cactctcgca gttcctccgc cttcaggaag gtcttttcag caggggcctt acgggtgcat    300

 gcttcggtcc tggaggcctt atcctagcct cctctccatc agcgccaccc gtctggggcc    360

 cgaaaggagg gagctttccc tctgtccccc agcctttgga ctgtcaccaa acaagccatt    420

 cgttcaccaa atacttatta agcgcctacc atgtgcctga caagggagat gtaacgagtc    480

 tctctctctg ccacccaggc cagagtgcag ttgacgcagg gcaggggagc cccgaagtgg    540

 agcatactgt gtccggaact ggagggttct tggtctccct gacttcaaga   atg aag     596
                                                          Met Lys
                                                            1

 cca cgg acc ctc ggg aaa ctc ctg gag ggc aga ggc atg cct gcc atc      644
 Pro Arg Thr Leu Gly Lys Leu Leu Glu Gly Arg Gly Met Pro Ala Ile
           5                  10                  15

 ttc atc att gca tta cca tca ccc aac act atc agg gaa cct gcc ctg      692
 Phe Ile Ile Ala Leu Pro Ser Pro Asn Thr Ile Arg Glu Pro Ala Leu
      20                  25                  30

 ata atc agt cta cag ttg tat cca gca gct cca gag aga cag cga cca      740
 Ile Ile Ser Leu Gln Leu Tyr Pro Ala Ala Pro Glu Arg Gln Arg Pro
  35                  40                  45                  50

 gca aga agg ggc cat gat gat ggt ggt ggt ttt ttc aaa acg aaa agg      788
 Ala Arg Arg Gly His Asp Asp Gly Gly Gly Phe Phe Lys Thr Lys Arg
                  55                  60                  65

 ggg ata tgt agg gaa aag aaa gag aga tca gac tct tac aga ctc tta      836
 Gly Ile Cys Arg Glu Lys Lys Glu Arg Ser Asp Ser Tyr Arg Leu Leu
              70                  75                  80

 ctg tgt cta cat aga aag gga aga cat aag aga ctc cat ttg gaa aaa      884
 Leu Cys Leu His Arg Lys Gly Arg His Lys Arg Leu His Leu Glu Lys
          85                  90                  95

 gac ctg tac ttt aaa caa ttg ctt tgc tga g atgttgttaa tctgtagctt      935
 Asp Leu Tyr Phe Lys Gln Leu Leu Cys 
     100                 105

 tgccccagcc actttgcccc aaccactttg acccagtctg gagctcacaa aaacatgtgt    995

 tgtatgaaat caaggtttaa ggcatgtagg gctgtgcagg gatgtgcctt gttaaccaaa   1055

 tgtttggcaa gcagtatact tggtaaaagt catcaccatt ctcttgtctc aataaaccgg   1115

 ggggcacaat gcactgcgga aagctgcagg gacctctgcc cttgaaagca gggtattgtt   1175

 caaggtttct ccccatgtga tagtctgaaa tatggcctcg tgggatgaga aagacctgac   1235

 tgtcccccag cctgacaccc gtaaagggtc tgtgctgagg tggattagta aaagaggaaa   1295

 gcctcttgca gttgagatag aggaaggcca ctgtctcctg cttgccccta ggaactgaat   1355

 gtctcagtgt aaaacccgat tgtacatttg ttcaactctg agacagca                1403




      <210> 373
      <211> 754
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (18)..(602)

      <400> 373
 ggtaggcgaa ggtgaag   atg gct gcc tct gcc ttt gct ggt gca gtg aga      50
                      Met Ala Ala Ser Ala Phe Ala Gly Ala Val Arg
                        1               5                  10

 gca gct tca ggt cag tgg aga gcg aca tac tcc atg cat gcc ttc aca       98
 Ala Ala Ser Gly Gln Trp Arg Ala Thr Tyr Ser Met His Ala Phe Thr
              15                  20                  25

 gaa ggg gaa act gga atc cta cgg tcc ctg aat att ttg gca tct tca      146
 Glu Gly Glu Thr Gly Ile Leu Arg Ser Leu Asn Ile Leu Ala Ser Ser
          30                  35                  40

 acc tac cgc aac tgt gtc aag aat gcc tct ctt att tct gca ttg tcc      194
 Thr Tyr Arg Asn Cys Val Lys Asn Ala Ser Leu Ile Ser Ala Leu Ser
      45                  50                  55

 act gga cgt ttt agt cat att cag aca cca gtt gtt tcc tcc act ccc      242
 Thr Gly Arg Phe Ser His Ile Gln Thr Pro Val Val Ser Ser Thr Pro
  60                  65                  70                  75

 aga ctt acc aca tct gag aga aac ctg aca tgt ggg cat acc tca gtg      290
 Arg Leu Thr Thr Ser Glu Arg Asn Leu Thr Cys Gly His Thr Ser Val
                  80                  85                  90

 atc ctt aat aga atg gcc ccc gtg ctt cca agt gtc ctg aag ctg cca      338
 Ile Leu Asn Arg Met Ala Pro Val Leu Pro Ser Val Leu Lys Leu Pro
              95                 100                 105

 gtc aga tct cta aca tac ttc agt gca aga aaa ggc aag aga aag acc      386
 Val Arg Ser Leu Thr Tyr Phe Ser Ala Arg Lys Gly Lys Arg Lys Thr
         110                 115                 120

 gtg aaa gct gtc atc gat agg ttt ctt cga ctt cat tgt ggc ctt tgg      434
 Val Lys Ala Val Ile Asp Arg Phe Leu Arg Leu His Cys Gly Leu Trp
     125                 130                 135

 gtg agg aga aag gct ggc tat aag aaa aaa tta tgg aaa aag aca cct      482
 Val Arg Arg Lys Ala Gly Tyr Lys Lys Lys Leu Trp Lys Lys Thr Pro
 140                 145                 150                 155

 gca agg aag aag cga ttg agg gaa ttt gta ttc tgc aat aaa acc cag      530
 Ala Arg Lys Lys Arg Leu Arg Glu Phe Val Phe Cys Asn Lys Thr Gln
                 160                 165                 170

 agt aaa ctc tta gat aaa atg acg acg tcc ttc tgg aag agg cga aac      578
 Ser Lys Leu Leu Asp Lys Met Thr Thr Ser Phe Trp Lys Arg Arg Asn
             175                 180                 185

 tgg cac tcc ccc att tgc aga tga agaaatgttc agagaagaaa aatgatggac     632
 Trp His Ser Pro Ile Cys Arg 
         190

 caaacgtctg tttgcacaat tgaaactcta ccagtggact attctatttt cacagctacc    692

 tagtttctgc cgatgatttt tttaaatgtg aaataaacag tgatactttc aaaaaaaaaa    752

 aa                                                                   754




      <210> 374
      <211> 1490
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (18)..(635)

      <400> 374
 cgtaggcgaa ggtgaag   atg gct gcc tct gcc ttt gct ggt gca gtg aga      50
                      Met Ala Ala Ser Ala Phe Ala Gly Ala Val Arg
                        1               5                  10

 gca gct tca ggt cag tgg aga gcg aca tac tcc atg cat gcc ttc aca       98
 Ala Ala Ser Gly Gln Trp Arg Ala Thr Tyr Ser Met His Ala Phe Thr
              15                  20                  25

 gaa ggg gaa act gga atc cta cgg ccc ctg aat att ttg gca tct tca      146
 Glu Gly Glu Thr Gly Ile Leu Arg Pro Leu Asn Ile Leu Ala Ser Ser
          30                  35                  40

 acc tac cgc aac tgt gtc aag aat gcc tct ctt att tct gca ttg tcc      194
 Thr Tyr Arg Asn Cys Val Lys Asn Ala Ser Leu Ile Ser Ala Leu Ser
      45                  50                  55

 act gga cgt ttt agt cat att cag aca cca gtt gtt tcc tcc act ccc      242
 Thr Gly Arg Phe Ser His Ile Gln Thr Pro Val Val Ser Ser Thr Pro
  60                  65                  70                  75

 aga ctt acc aca tct gag aga aac ctg aca tgt ggg cat acc tca gtg      290
 Arg Leu Thr Thr Ser Glu Arg Asn Leu Thr Cys Gly His Thr Ser Val
                  80                  85                  90

 atc ctt aat aga atg gcc ccc gtg ctt cca agt gtc ctg aag ctg cca      338
 Ile Leu Asn Arg Met Ala Pro Val Leu Pro Ser Val Leu Lys Leu Pro
              95                 100                 105

 gtc aga tct cta aca tac ttc agt gca aga aaa ggc aag aga aag acc      386
 Val Arg Ser Leu Thr Tyr Phe Ser Ala Arg Lys Gly Lys Arg Lys Thr
         110                 115                 120

 gtg aaa gct gtc atc gat agg ttt ctt cga ctt cat tgt ggc ctt tgg      434
 Val Lys Ala Val Ile Asp Arg Phe Leu Arg Leu His Cys Gly Leu Trp
     125                 130                 135

 gtg agg aga aag gct ggc tat aag aaa aaa tta tgg aaa aag aca cct      482
 Val Arg Arg Lys Ala Gly Tyr Lys Lys Lys Leu Trp Lys Lys Thr Pro
 140                 145                 150                 155

 gca agg aag aag cga ttg agg gaa ttt gta ttc tgc aat aaa acc cag      530
 Ala Arg Lys Lys Arg Leu Arg Glu Phe Val Phe Cys Asn Lys Thr Gln
                 160                 165                 170

 agt aaa ctc tta gat aaa atg acg acg tcc ttc tgg aag agg cga aac      578
 Ser Lys Leu Leu Asp Lys Met Thr Thr Ser Phe Trp Lys Arg Arg Asn
             175                 180                 185

 tgg tac gtt gat gat cct tat cag aag tat cat gat cga aca aac ctg      626
 Trp Tyr Val Asp Asp Pro Tyr Gln Lys Tyr His Asp Arg Thr Asn Leu
         190                 195                 200

 aaa gta tag atcagaa gtttcacttg tttctcagtt attggatatg tatctttgtg      682
 Lys Val 
     205

 tacatatctt tgcaaaaatg gataagtaca aaacttgatg taaattgtac caatgaatat    742

 gtaaacatac agtgacaaca ttaaacttag aaaagtttta aaacttaatg gatcagactt    802

 tgccagattt ggttagggaa acagaaattt agaatggtgc attattttta acaaatggta    862

 ttggcttaac tagttgtttc agttatgctc ttttagttgc aaggaatctc aagtgggaca    922

 aacataaaaa gactcaaaag ctacaagtta gctcaagcaa tgtgacatta tttcaaggat    982

 atgtgccagg gaattcagga accacctcgc caaccccatc tcccactcag aaatcacctc   1042

 ccagcctcag gaagagtaga aattgggtgg tgctcctcag caggggaagg tggatgttta   1102

 gcgattgggc tctgcatgca tgtgaacttg ctctttgtgg atggtgactc caaataataa   1162

 ataagacagt ttctttaaca gttatggaat aataaagata ggacctgtgg aaaactttat   1222

 tgcaccatga gagagtactt acatagagaa ggcaccttaa acagggacaa tagcatacca   1282

 catggcccgg ggaactaaac tgaggcaaag aaaccaaaaa cactaagacg agcgagaaac   1342

 gagcagacaa ggcaggaggg acacaaaagc agcgcagtat aaacacgcta ggagaaaaaa   1402

 atggtgcgca aaccgagaac gagggaagaa acaacaaaaa aaggggaaac cgacaaaata   1462

 aacaaagaga agacacgaga cacagaca                                      1490




      <210> 375
      <211> 969
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (1)..(969)

      <400> 375
  atg tgc ctg ctg cgt gca ggc gtc gct ggg cct ggg tct gcc cgg gct      48
  Met Cys Leu Leu Arg Ala Gly Val Ala Gly Pro Gly Ser Ala Arg Ala
    1               5                  10                  15

 gtg ccc act gcc tcc cag tgc ccc ttt gtg gat ctg gca aag ctc tcc       96
 Val Pro Thr Ala Ser Gln Cys Pro Phe Val Asp Leu Ala Lys Leu Ser
              20                  25                  30

 tgg ggg gct gta aac acg ggc ctg agc cca tcc cct ctt cta gtc ttc      144
 Trp Gly Ala Val Asn Thr Gly Leu Ser Pro Ser Pro Leu Leu Val Phe
          35                  40                  45

 cat gac acc tac cct ggc tcc cca gac cct aag gaa tca ggc tgt tgg      192
 His Asp Thr Tyr Pro Gly Ser Pro Asp Pro Lys Glu Ser Gly Cys Trp
      50                  55                  60

 gct aac cct gga cca ttc cct ggg gaa ccg gga cag ggt aag gtg gca      240
 Ala Asn Pro Gly Pro Phe Pro Gly Glu Pro Gly Gln Gly Lys Val Ala
  65                  70                  75                  80

 ttc cct gga gaa ccg gga acc ggg acc cgc ccg tat cag tcc aac cgg      288
 Phe Pro Gly Glu Pro Gly Thr Gly Thr Arg Pro Tyr Gln Ser Asn Arg
                  85                  90                  95

 atg gcc aaa tgt gcg gct gca tcc ctt ggc tgg ctc atc tgg cag atc      336
 Met Ala Lys Cys Ala Ala Ala Ser Leu Gly Trp Leu Ile Trp Gln Ile
             100                 105                 110

 ctc ctt agg agg aga cct gta cct gtt aaa ccc tgc agc ttc cta agg      384
 Leu Leu Arg Arg Arg Pro Val Pro Val Lys Pro Cys Ser Phe Leu Arg
         115                 120                 125

 ggc aca gtc ccg gag acc cac caa gac agc gcc tgg att cca gcc tct      432
 Gly Thr Val Pro Glu Thr His Gln Asp Ser Ala Trp Ile Pro Ala Ser
     130                 135                 140

 ccc agc cac ccc agt gcc atc ctc tca ccc aag acc tgg act gag agc      480
 Pro Ser His Pro Ser Ala Ile Leu Ser Pro Lys Thr Trp Thr Glu Ser
 145                 150                 155                 160

 cac ctg ggg ctc ctg tgg cca gcc tgc ggg ccc atc cct gtg ccc tgg      528
 His Leu Gly Leu Leu Trp Pro Ala Cys Gly Pro Ile Pro Val Pro Trp
                 165                 170                 175

 tca gcc acg ctg ctg agc agg acc cct gct gtt cgc ctc aag ggc cgt      576
 Ser Ala Thr Leu Leu Ser Arg Thr Pro Ala Val Arg Leu Lys Gly Arg
             180                 185                 190

 cat cgt gtg cgc cac tcg ggt ctt tgc atg gcg aag ctt tct cag gtc      624
 His Arg Val Arg His Ser Gly Leu Cys Met Ala Lys Leu Ser Gln Val
         195                 200                 205

 ctg agc gag gca gtg cct ggt gcc tgc tgc tcc cca agt ctt tac cac      672
 Leu Ser Glu Ala Val Pro Gly Ala Cys Cys Ser Pro Ser Leu Tyr His
     210                 215                 220

 gtg gcg gac cct gcc tgt gga gtg aag ctc aac ctc gag gac acc gaa      720
 Val Ala Asp Pro Ala Cys Gly Val Lys Leu Asn Leu Glu Asp Thr Glu
 225                 230                 235                 240

 caa gat acg gac aca cac aga gga gcc aaa cca aac ccc gaa caa agg      768
 Gln Asp Thr Asp Thr His Arg Gly Ala Lys Pro Asn Pro Glu Gln Arg
                 245                 250                 255

 gag gaa aat ccg aag gaa acc gag tgg ttg ggc ttc aaa gac acc atg      816
 Glu Glu Asn Pro Lys Glu Thr Glu Trp Leu Gly Phe Lys Asp Thr Met
             260                 265                 270

 aag atg gaa gaa tct cag cgc ttc gcc ttg gga tat ggg gag aaa agc      864
 Lys Met Glu Glu Ser Gln Arg Phe Ala Leu Gly Tyr Gly Glu Lys Ser
         275                 280                 285

 aaa gct aac aag aat gcc ttc gga cgg ctt tca agc aca gac ctc aga      912
 Lys Ala Asn Lys Asn Ala Phe Gly Arg Leu Ser Ser Thr Asp Leu Arg
     290                 295                 300

 gga ctc gac tct tct ttg gaa aaa tgg atg cca aag gag gag ata aag      960
 Gly Leu Asp Ser Ser Leu Glu Lys Trp Met Pro Lys Glu Glu Ile Lys
 305                 310                 315                 320

 aag gtt taa                                                          969
 Lys Val 






      <210> 376
      <211> 3675
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (1518)..(2795)

      <220>
      <221> misc_feature
      <222> (1)...(3675)
      <223> n = a,t,c or g

      <400> 376
 cggggtggcg gccnccgcct ggtcctgtga gcgttcggag actgcgggcg cgcaaacctg     60

 tactgggccc gcgccccggc cccttacaga gctgggtgtg tccctccgag tgccccccgc    120

 tagggactgt gcaggccgga gctaggcagg gacagcgggg cgaaccgggc tgatagagtc    180

 ggtccctgct cctgtgaggc tctcaccgaa tccctgctgt ttccgggcag ctgaagagcg    240

 ctgggccctc gcgtcgcggg cgtggctgtg gccgtgtctc ctggtagtct gagcccactg    300

 tgcgtgtgga tccacgtggg agctgggttc cagagcctgg tcctgaggag gagccgagcc    360

 ggggcttccc cttctcagaa tcctgctctt cctccagaga gattcccagg agaagaggga    420

 acaaccaatt cattcctgaa agccaggcct cgggacctga tgacatttga agatgtggct    480

 gtggaattca gccagtggga gtgggggcag ctgaaccctg ctcagaagga cctctacagg    540

 gaggtgatgc tggagaactt caggaacttg gccattctgg gccttctagt atccaaacca    600

 tatgtgatct gccagttgga ggaagagcag gattctgaga aggggaagct ggaaaaacgt    660

 agctttgttc ctgaagtaag attttatcat attctttgta attttcagtc ttccctgaga    720

 tgtagctcag tggttcctag ctttagctgc acattagagt cacctgcagc tcttttcaaa    780

 ctgtcgctcc acagctgggc ctcaggcatc aatgtcgaaa gctctccggg tgattccagc    840

 ttgcagccag ggccgttcca gcaactccaa ggctggctgg tgtgcgctga agctgtcggg    900

 agtcggacca gctgcacagt taatacatat gtgtcctagg ctcctctctc cttccaacgc    960

 aaatatgtgt acaaaccctg cctggaaccg cagccctgct ctcagaatca aattcctgaa   1020

 agtgggcaag cggaagcgga aataagccct ctcccaacgc cagctgactc gatttcgtct   1080

 cggtcttccc cagagctgga cacgaggcac catgatcaga gagacacatt ccctgcggac   1140

 ggcgctccca tcggatactg gagggacgcg acactagagg caggcagtac ttcagggtga   1200

 ccataagtct cccaaacagc cacaacggct cgctctccca gctaaggcga cagcgctgcc   1260

 attttggatc ctgttcagcc acgggaagcc ggcgtttgca cacattttcg gacgtcatat   1320

 taaagcgcac cggacgccga gacttctggg agatgaagtc cttgcgaagg ccccgcattg   1380

 attgggagcg cagtcgccag gaccctgtgc gcaggcgcgt tggtttcccg acctgaagag   1440

 gcgccgtctt cccgggtccc gagcactctg tgccggagga ctctgccctt gtccacaagg   1500

 agagcacaca ggagaga   atg gct gct gtg tct ccg acc acc aga tgc cag    1550
                      Met Ala Ala Val Ser Pro Thr Thr Arg Cys Gln
                        1               5                  10

 gaa tca gtg aca ttc gaa gac gtt gcc gtg gtt ttc aca gat gaa gag     1598
 Glu Ser Val Thr Phe Glu Asp Val Ala Val Val Phe Thr Asp Glu Glu
              15                  20                  25

 tgg agt cgt ctg gtc ccc ata cag agg gac ctc tac aag gag gtg atg     1646
 Trp Ser Arg Leu Val Pro Ile Gln Arg Asp Leu Tyr Lys Glu Val Met
          30                  35                  40

 ctg gag aac tat aac agc att gtg tca ttg ggc ctt cca gtt cct caa     1694
 Leu Glu Asn Tyr Asn Ser Ile Val Ser Leu Gly Leu Pro Val Pro Gln
      45                  50                  55

 cct gat gtg att ttc caa ttg aag aga ggg gac aag ccg tgg atg gta     1742
 Pro Asp Val Ile Phe Gln Leu Lys Arg Gly Asp Lys Pro Trp Met Val
  60                  65                  70                  75

 gat ctt cat ggg tct gag gag aga gaa tgg cca gag agt gtc tct cta     1790
 Asp Leu His Gly Ser Glu Glu Arg Glu Trp Pro Glu Ser Val Ser Leu
                  80                  85                  90

 gac tgg gaa act aag cct gag att cac gat gct tca gac aaa aaa tca     1838
 Asp Trp Glu Thr Lys Pro Glu Ile His Asp Ala Ser Asp Lys Lys Ser
              95                 100                 105

 gaa gga tca ttg agg gaa tgc ctt gga agg caa agt cct ctg tgt cct     1886
 Glu Gly Ser Leu Arg Glu Cys Leu Gly Arg Gln Ser Pro Leu Cys Pro
         110                 115                 120

 aaa ttt gaa gtt cat aca ccc aat ggc agg atg gga aca gaa aag caa     1934
 Lys Phe Glu Val His Thr Pro Asn Gly Arg Met Gly Thr Glu Lys Gln
     125                 130                 135

 agc cct tca ggg gag act cgt aag aaa tcc ctc tcc cgg gac aaa ggc     1982
 Ser Pro Ser Gly Glu Thr Arg Lys Lys Ser Leu Ser Arg Asp Lys Gly
 140                 145                 150                 155

 ttg cgg cga cgg tca gcc ctg tcc agg gaa att ctc act aaa gag aga     2030
 Leu Arg Arg Arg Ser Ala Leu Ser Arg Glu Ile Leu Thr Lys Glu Arg
                 160                 165                 170

 cac cag gaa tgc agt gac tgt ggg aag acc ttt ttt gac cac tca tcc     2078
 His Gln Glu Cys Ser Asp Cys Gly Lys Thr Phe Phe Asp His Ser Ser
             175                 180                 185

 ctc acc cgc cat cag agg act cac act ggg gag aag ccc tac gac tgc     2126
 Leu Thr Arg His Gln Arg Thr His Thr Gly Glu Lys Pro Tyr Asp Cys
         190                 195                 200

 cgc gag tgt ggg aaa gcc ttc agc cac agg agc agc ctc agc aga cat     2174
 Arg Glu Cys Gly Lys Ala Phe Ser His Arg Ser Ser Leu Ser Arg His
     205                 210                 215

 ctg atg tca cac act ggg gag agc ccc tac gag tgc agt gtg tgc tca     2222
 Leu Met Ser His Thr Gly Glu Ser Pro Tyr Glu Cys Ser Val Cys Ser
 220                 225                 230                 235

 aaa gcc ttc ttt gac cgt tcg tcc cta act gtc cat cag cga att cac     2270
 Lys Ala Phe Phe Asp Arg Ser Ser Leu Thr Val His Gln Arg Ile His
                 240                 245                 250

 act gga gag aaa ccc ttt cag tgc aac gag tgt gga aaa gcc ttt ttt     2318
 Thr Gly Glu Lys Pro Phe Gln Cys Asn Glu Cys Gly Lys Ala Phe Phe
             255                 260                 265

 gac cgt tca tcc ctt act cga cac cag aga att cac act gga gaa agt     2366
 Asp Arg Ser Ser Leu Thr Arg His Gln Arg Ile His Thr Gly Glu Ser
         270                 275                 280

 cct tat gaa tgt cat cag tgt ggg aaa gcc ttt agc cag aaa agt att     2414
 Pro Tyr Glu Cys His Gln Cys Gly Lys Ala Phe Ser Gln Lys Ser Ile
     285                 290                 295

 ctt act cgc cat cag cta atc cac act ggc agg aag cct tat gag tgt     2462
 Leu Thr Arg His Gln Leu Ile His Thr Gly Arg Lys Pro Tyr Glu Cys
 300                 305                 310                 315

 aac gag tgc ggg aaa gct ttc tat ggt gtc tcg tct ctg aat aga cat     2510
 Asn Glu Cys Gly Lys Ala Phe Tyr Gly Val Ser Ser Leu Asn Arg His
                 320                 325                 330

 cag aaa gct cat gct ggg gac cct cgc tat cag tgt aac gag tgt ggc     2558
 Gln Lys Ala His Ala Gly Asp Pro Arg Tyr Gln Cys Asn Glu Cys Gly
             335                 340                 345

 aaa gct ttc ttt gac cgc tca tcc ctt aca cag cat cag aag atc cac     2606
 Lys Ala Phe Phe Asp Arg Ser Ser Leu Thr Gln His Gln Lys Ile His
         350                 355                 360

 act gga gac aag cca tat gaa tgc agc gaa tgc ggg aaa gcc ttt agc     2654
 Thr Gly Asp Lys Pro Tyr Glu Cys Ser Glu Cys Gly Lys Ala Phe Ser
     365                 370                 375

 cag cgg tgc cgg ctc acg cgg cat cag cgt gtc cac acg gga gag aag     2702
 Gln Arg Cys Arg Leu Thr Arg His Gln Arg Val His Thr Gly Glu Lys
 380                 385                 390                 395

 ccc ttt gaa tgc act gtg tgt ggg aaa gtt ttc agt tca aaa tct tct     2750
 Pro Phe Glu Cys Thr Val Cys Gly Lys Val Phe Ser Ser Lys Ser Ser
                 400                 405                 410

 gtt att caa cat caa cgg cgt tac gcc aaa cag gga ata gac tga gtt     2798
 Val Ile Gln His Gln Arg Arg Tyr Ala Lys Gln Gly Ile Asp 
             415                 420                 425

 gggcaaaagc ttgggtagga caagaacttc catacaaatt tgagatagat ctcgcctgtc   2858

 ttaaagctgc catttgctca ttctacccac tctggctgcc gttgtcctgt cctgcttctg   2918

 cgccagagtg tttaataagc actcccttcc tgctgtgtta cagaactgta ggggaggcca   2978

 tggaaatgac tctaaagata caaaattttg aagaggtttg tcagacaata ggatagatgt   3038

 taggaggaga cacacctctt gtctgagaac ctaggcccca ggtatcactg cactttaaga   3098

 aactggaggc tgcaacagga gggaaaggca gaatgatatc acagcagtac tatttttttt   3158

 tttcagaaca tttgttttga tggctgttag tccccctctc ttggagcatt ttggggcact   3218

 aatcttgttc tcttgtgtcc cagcttttag acctcttact tccactgcta gtagctagca   3278

 cttactgagc acctgcaatg aggtaaagac tcagctaagg gttttacagg aagtagatta   3338

 attgatcctg tcaccaacca tatgaagtag gcactgttac catctgcatc tccagatgag   3398

 caccctgagg tttagagaga ttaaatcact tgcccaaagg tgaaccagct ggtaaaaggt   3458

 gatgccaggt cttgaagaca ggtccacctt caaaatctat tctctttacc attatgctcg   3518

 atggtttgtt tgttttataa tttatgtata tgtattatcc tctcaactag attgtaagca   3578

 cttggaggtg tgacttacag gtctttgtat ctcacacagt gccttgctaa taggtgctca   3638

 ataaatattt atatgagtga aaaaaaaaaa aaaaaaa                            3675




      <210> 377
      <211> 318
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (1)..(318)

      <400> 377
  atg aca ttg ggt agc att aac tgt aag ttt gtg ctt cca aat cac ttt      48
  Met Thr Leu Gly Ser Ile Asn Cys Lys Phe Val Leu Pro Asn His Phe
    1               5                  10                  15

 tgg gtt ttt aaa gaa ttt ctt gat act ctt ata gcc tgc ctt caa ttt       96
 Trp Val Phe Lys Glu Phe Leu Asp Thr Leu Ile Ala Cys Leu Gln Phe
              20                  25                  30

 gat cct tta ttc ttt cta ttt gtc agg tgc aca aga tta cct tcc tgt      144
 Asp Pro Leu Phe Phe Leu Phe Val Arg Cys Thr Arg Leu Pro Ser Cys
          35                  40                  45

 ttt agc ctt ctg tct tgt cac caa cca ttc tta ctt ggt ggc cat gta      192
 Phe Ser Leu Leu Ser Cys His Gln Pro Phe Leu Leu Gly Gly His Val
      50                  55                  60

 ctt gga aaa agg ccg cat gat ctt tct ggc tcc act cag tgt ctt aag      240
 Leu Gly Lys Arg Pro His Asp Leu Ser Gly Ser Thr Gln Cys Leu Lys
  65                  70                  75                  80

 gca ccc tgc ttc ctt tgc ttg cat ccc aca gac tat ttc cct cat cct      288
 Ala Pro Cys Phe Leu Cys Leu His Pro Thr Asp Tyr Phe Pro His Pro
                  85                  90                  95

 att tac tgc agc aaa tct ctc ctt agt tga                              318
 Ile Tyr Cys Ser Lys Ser Leu Leu Ser 
             100                 105





      <210> 378
      <211> 372
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (106)..(372)

      <400> 378
 ttctggggga tgagctgact ggtcttaatc tgtgatgttc agctagtcaa tttaggggat     60

 ttacatgact aaacaaaaag tctccttttg attccattgc agtta    atg ctt gaa     114
                                                      Met Leu Glu
                                                        1

 tgt gct ttc acc ttt tgt gat gtt atg tgc cag ttc att aac tgg aca      162
 Cys Ala Phe Thr Phe Cys Asp Val Met Cys Gln Phe Ile Asn Trp Thr
       5                  10                  15

 cct tca cca gtc agg gtc ttg gca aaa cac aga ggt tat cct gaa att      210
 Pro Ser Pro Val Arg Val Leu Ala Lys His Arg Gly Tyr Pro Glu Ile
  20                  25                  30                  35

 ggg tgg att gga gag ttt aat aat gat ggg atc att cac aaa ggg tgt      258
 Gly Trp Ile Gly Glu Phe Asn Asn Asp Gly Ile Ile His Lys Gly Cys
                  40                  45                  50

 ggg caa gga aaa gca gct atg gca gca aca tgg ttg gca ata cta cta      306
 Gly Gln Gly Lys Ala Ala Met Ala Ala Thr Trp Leu Ala Ile Leu Leu
              55                  60                  65

 gac ctg aag agg caa agg aat gaa gga gtg acc aga cct gga gac gta      354
 Asp Leu Lys Arg Gln Arg Asn Glu Gly Val Thr Arg Pro Gly Asp Val
          70                  75                  80

 gtt gag gcc tgt ttg tag                                              372
 Val Glu Ala Cys Leu 
      85





      <210> 379
      <211> 1104
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (758)..(1036)

      <400> 379
 gaaattatct gcttgaaaag atcaagagat caggatactt agctcttcac aaatatgaag     60

 tcattatcac atttcactga gccagaaatc actgttaaca gcacacacaa aagactacac    120

 tggttgaaca gcaaagagaa acccgggtct ccagaatcac agtttagtcc ttctatatta    180

 ctgcaagtga cctgtttttt ctgaaggctc cccgcaaatg aagtcctgga atggaaaaaa    240

 tccataagtc cataaattaa cttgataaat attttagaac agacaaaaga aaatattgag    300

 tgatgtagtt ctaatcctcc taatatggaa cctggcaaga ctgaatcatt ttactgtgaa    360

 atatataaac acaatagaat gagccaacat gatggtttct ctccagtaag agtttttctt    420

 ttggaaatga ggttaaccta gccccaaatc tagcaattct cataaaatcc gattttagaa    480

 ttagcctccc agattaatct gaatgattga cttatttttt cttaggcaag tcagtaagcc    540

 acccactaga cagccatatc cagcaaaata agagaagttt ccagatgcca aatgataagc    600

 caccatcaac ccagcgggga agccttctgg ttggtttggc tgtatgagat tcaggaaggc    660

 cagaataccc aaaattattc acacgacgtt aacttattgg tactggctaa gcaatacatg    720

 tatttcctaa aggaggagat ggtcttttgg ttgattt atg gac aca ctt gtt tca     775
                                          Met Asp Thr Leu Val Ser
                                            1               5

 tct gac tgt aaa tat att gca tgc ttt att ctg atg gtg cac tat ttc      823
 Ser Asp Cys Lys Tyr Ile Ala Cys Phe Ile Leu Met Val His Tyr Phe
              10                  15                  20

 atc cag caa gct ttt cat ctg aga atg ttt aat gtt gac ctt att ctt      871
 Ile Gln Gln Ala Phe His Leu Arg Met Phe Asn Val Asp Leu Ile Leu
          25                  30                  35

 aga gca agt aga tct aaa tat ttt tca gct gag tta tta ggg agt cat      919
 Arg Ala Ser Arg Ser Lys Tyr Phe Ser Ala Glu Leu Leu Gly Ser His
      40                  45                  50

 tat tct gtg gta caa tgc tgc aaa aag cat cat gtg gaa gaa tgg gaa      967
 Tyr Ser Val Val Gln Cys Cys Lys Lys His His Val Glu Glu Trp Glu
  55                  60                  65                  70

 cta tgc tta ctt tat gaa gtg atg tat aac aca atg aaa tct gtt tta     1015
 Leu Cys Leu Leu Tyr Glu Val Met Tyr Asn Thr Met Lys Ser Val Leu
                  75                  80                  85

 caa cta ctg tgc tgc att taa tt atcttccatt tttgctgtta aaaaaaaaaa     1068
 Gln Leu Leu Cys Cys Ile 
              90

 atccgttaat gatgtcaaaa aaaaaaaaaa aaaaag                             1104




      <210> 380
      <211> 1529
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (57)..(1475)

      <400> 380
 aggggagcgc gctgcgcgtc gcaggagtaa cctacttggt ctcctgcttt cgcgac         56                                                                 
 atg gcc ttc aat ttt ggg gct ccc tcg ggc acc tcc ggt acc gct gca      104
 Met Ala Phe Asn Phe Gly Ala Pro Ser Gly Thr Ser Gly Thr Ala Ala
   1               5                  10                  15

 gcc acc gcg gcc ccc gcg ggt ggg ttt gga gga ttt ggg aca aca tct      152
 Ala Thr Ala Ala Pro Ala Gly Gly Phe Gly Gly Phe Gly Thr Thr Ser
              20                  25                  30

 aca act gca ggt tct gcg ttc agc ttt tct gcc cca act aac aca ggc      200
 Thr Thr Ala Gly Ser Ala Phe Ser Phe Ser Ala Pro Thr Asn Thr Gly
          35                  40                  45

 act act gga ctc ttt ggt ggt act cag aac aaa ggt ttt gga ttt ggt      248
 Thr Thr Gly Leu Phe Gly Gly Thr Gln Asn Lys Gly Phe Gly Phe Gly
      50                  55                  60

 act ggt ttt ggc aca aca acg gga act agt act ggt tta ggt act ggt      296
 Thr Gly Phe Gly Thr Thr Thr Gly Thr Ser Thr Gly Leu Gly Thr Gly
  65                  70                  75                  80

 ttg gga act gga ctg gga ttt gga gga ttt aat aca caa cag cag cag      344
 Leu Gly Thr Gly Leu Gly Phe Gly Gly Phe Asn Thr Gln Gln Gln Gln
                  85                  90                  95

 cag caa act aca tta ggt ggt ctc ttc agt cag cct aca caa gct cct      392
 Gln Gln Thr Thr Leu Gly Gly Leu Phe Ser Gln Pro Thr Gln Ala Pro
             100                 105                 110

 acc cag tcc aac cag ctg ata aat acc gcg agt gct ctt tct gct cca      440
 Thr Gln Ser Asn Gln Leu Ile Asn Thr Ala Ser Ala Leu Ser Ala Pro
         115                 120                 125

 acg ctg ttg gga gat gag aga gat gct att ttg gca aaa tgg aat caa      488
 Thr Leu Leu Gly Asp Glu Arg Asp Ala Ile Leu Ala Lys Trp Asn Gln
     130                 135                 140

 ctg cag gcc ttt tgg gga aca gga aaa ggg tat ttc aac aat aat att      536
 Leu Gln Ala Phe Trp Gly Thr Gly Lys Gly Tyr Phe Asn Asn Asn Ile
 145                 150                 155                 160

 ccg cca gtg gaa ttc aca caa gaa aat ccc ttt tgc cga ttt aag gca      584
 Pro Pro Val Glu Phe Thr Gln Glu Asn Pro Phe Cys Arg Phe Lys Ala
                 165                 170                 175

 gta ggt tat agt tgc atg ccc agt aat aaa gat gaa gac ggg cta gtg      632
 Val Gly Tyr Ser Cys Met Pro Ser Asn Lys Asp Glu Asp Gly Leu Val
             180                 185                 190

 gtt tta gtt ttc aac aaa aaa gaa aca gag att cga agc caa caa caa      680
 Val Leu Val Phe Asn Lys Lys Glu Thr Glu Ile Arg Ser Gln Gln Gln
         195                 200                 205

 cag ttg gta gaa tca ttg cat aaa gtt ttg gga gga aac cag acc ctt      728
 Gln Leu Val Glu Ser Leu His Lys Val Leu Gly Gly Asn Gln Thr Leu
     210                 215                 220

 act gta aat gta gag ggc act aaa aca ttg cca gat gat cag aca gaa      776
 Thr Val Asn Val Glu Gly Thr Lys Thr Leu Pro Asp Asp Gln Thr Glu
 225                 230                 235                 240

 gtt gtt att tat gtt gtt gag cgt tcg cca aat ggt act tca aga aga      824
 Val Val Ile Tyr Val Val Glu Arg Ser Pro Asn Gly Thr Ser Arg Arg
                 245                 250                 255

 gtt cca gct aca acg cta tat gcc cat ttt gaa caa gcc aat ata aaa      872
 Val Pro Ala Thr Thr Leu Tyr Ala His Phe Glu Gln Ala Asn Ile Lys
             260                 265                 270

 aca caa ttg cag caa ctt ggt gta acc ctt tct atg act aga aca gaa      920
 Thr Gln Leu Gln Gln Leu Gly Val Thr Leu Ser Met Thr Arg Thr Glu
         275                 280                 285

 ctt tct cct gca cag atc aaa cag ctt tta cag aat cct cct gct ggt      968
 Leu Ser Pro Ala Gln Ile Lys Gln Leu Leu Gln Asn Pro Pro Ala Gly
     290                 295                 300

 gtt gat cct att atc tgg gaa cag gcc aag gta gat aac tct gat tct     1016
 Val Asp Pro Ile Ile Trp Glu Gln Ala Lys Val Asp Asn Ser Asp Ser
 305                 310                 315                 320

 gaa aag tta att cct gta cca atg gtg ggt ttt aag gaa ctt ctc cga     1064
 Glu Lys Leu Ile Pro Val Pro Met Val Gly Phe Lys Glu Leu Leu Arg
                 325                 330                 335

 aga ctg aag gtt caa gat cag atg act aag cag cat caa acc aga tta     1112
 Arg Leu Lys Val Gln Asp Gln Met Thr Lys Gln His Gln Thr Arg Leu
             340                 345                 350

 gat gtc cta atc aaa cag gaa att caa agg aag agt ggt tat gcc att     1160
 Asp Val Leu Ile Lys Gln Glu Ile Gln Arg Lys Ser Gly Tyr Ala Ile
         355                 360                 365

 cag gct gat gaa gag cag ttg cga gtt cag ctg gat acg att cag ggt     1208
 Gln Ala Asp Glu Glu Gln Leu Arg Val Gln Leu Asp Thr Ile Gln Gly
     370                 375                 380

 gaa cta aat gca cct act cag ttc aag ggc cga cta aat gaa ttg atg     1256
 Glu Leu Asn Ala Pro Thr Gln Phe Lys Gly Arg Leu Asn Glu Leu Met
 385                 390                 395                 400

 tct caa atc agg atg cag aat cat ttt gga gca gtc aga tct gaa gaa     1304
 Ser Gln Ile Arg Met Gln Asn His Phe Gly Ala Val Arg Ser Glu Glu
                 405                 410                 415

 agg tat tac ata gat gca gat ctg tta cga gaa atc aag cag cat ttg     1352
 Arg Tyr Tyr Ile Asp Ala Asp Leu Leu Arg Glu Ile Lys Gln His Leu
             420                 425                 430

 aaa caa caa cag gaa ggc ctt agc cat ttg att agc atc att aaa gac     1400
 Lys Gln Gln Gln Glu Gly Leu Ser His Leu Ile Ser Ile Ile Lys Asp
         435                 440                 445

 gat cta gaa gat ata aag ctg gtc gaa cat gga ttg aat gaa acc atc     1448
 Asp Leu Glu Asp Ile Lys Leu Val Glu His Gly Leu Asn Glu Thr Ile
     450                 455                 460

 cac atc aga ggt ggt gtc ttt agt tga cagtt cacaaacttg tgtaaaggtt     1500
 His Ile Arg Gly Gly Val Phe Ser 
 465                 470

 tgtgaaatgc atcttcttac tgcatcaga                                     1529




      <210> 381
      <211> 412
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (114)..(362)

      <400> 381
 gcagatgctg cttcattaaa tataaagtta acaaaatgtc agagagctca ataaaaacct     60

 tccacccgtc agtctagaag gataagagaa agaaagttaa gcaactacag gaa   atg     116
                                                              Met
                                                                1

 gct ttg gga gtt cca ata tca gtc tat ctt tta ttc aac gct gac aac      164
 Ala Leu Gly Val Pro Ile Ser Val Tyr Leu Leu Phe Asn Ala Asp Asn
               5                  10                  15

 ata gaa gga ccc ata gcc ttg aag ttc tca cac ctt tgc ctg gaa gat      212
 Ile Glu Gly Pro Ile Ala Leu Lys Phe Ser His Leu Cys Leu Glu Asp
          20                  25                  30

 cat aac agt tac tgc atc aac ggt gct tgt gca ttc cac cat gag cta      260
 His Asn Ser Tyr Cys Ile Asn Gly Ala Cys Ala Phe His His Glu Leu
      35                  40                  45

 gag aaa gcc atc tgc agg tgt ttt act ggt tat act gga gaa agg tgt      308
 Glu Lys Ala Ile Cys Arg Cys Phe Thr Gly Tyr Thr Gly Glu Arg Cys
  50                  55                  60                  65

 cta aaa ttg aaa tcg cct tac aat gtc tgt tct gga gaa aga cga cca      356
 Leu Lys Leu Lys Ser Pro Tyr Asn Val Cys Ser Gly Glu Arg Arg Pro
                  70                  75                  80

 ctg tga ggcctttgtg aagaattttc atcaaggcat ctgtagagat cagtgagccc       412
 Leu 






      <210> 382
      <211> 683
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (24)..(629)

      <400> 382
 tccctggtgc tccccgcgca gcc    atg gct cag cac ttc tcc ctg gcc gcc      50
                              Met Ala Gln His Phe Ser Leu Ala Ala
                                1               5

 tgc gac gtg gtc gga ttc gac ctg gac cac act ctg tgt cgc tac aac       98
 Cys Asp Val Val Gly Phe Asp Leu Asp His Thr Leu Cys Arg Tyr Asn
  10                  15                  20                  25

 ctg ccc gag agc gcc ccg ctc att tat aat agc ttt gcc cag ttc cta      146
 Leu Pro Glu Ser Ala Pro Leu Ile Tyr Asn Ser Phe Ala Gln Phe Leu
                  30                  35                  40

 gtt aag gag aaa ggg tac gat aag gaa ttg ctc aat gtg acc cca gag      194
 Val Lys Glu Lys Gly Tyr Asp Lys Glu Leu Leu Asn Val Thr Pro Glu
              45                  50                  55

 gat tgg gat ttc tgt tgc aaa ggt ttg gca ttg gat cta gaa gat ggg      242
 Asp Trp Asp Phe Cys Cys Lys Gly Leu Ala Leu Asp Leu Glu Asp Gly
          60                  65                  70

 aac ttc ctt aaa ctt gca aat aat ggc act gtt ctc agg gca agc cat      290
 Asn Phe Leu Lys Leu Ala Asn Asn Gly Thr Val Leu Arg Ala Ser His
      75                  80                  85

 ggc acc aag atg atg act cca gag gtg ctg gca gag gca tat ggc aag      338
 Gly Thr Lys Met Met Thr Pro Glu Val Leu Ala Glu Ala Tyr Gly Lys
  90                  95                 100                 105

 aaa gag tgg aag cac ttc ttg tcg gac act gga atg gct tgc cgc tca      386
 Lys Glu Trp Lys His Phe Leu Ser Asp Thr Gly Met Ala Cys Arg Ser
                 110                 115                 120

 gga aag tat tac ttt tac gac aac tac ttt gac ctg cca gga gct ctt      434
 Gly Lys Tyr Tyr Phe Tyr Asp Asn Tyr Phe Asp Leu Pro Gly Ala Leu
             125                 130                 135

 ctg tgt gcc agg gtg gtg gac tat tta aca aaa ctg aac aat ggt caa      482
 Leu Cys Ala Arg Val Val Asp Tyr Leu Thr Lys Leu Asn Asn Gly Gln
         140                 145                 150

 aaa aca ttt gat ttt tgg aag gat ata gtt gct gct ata caa cac aat      530
 Lys Thr Phe Asp Phe Trp Lys Asp Ile Val Ala Ala Ile Gln His Asn
     155                 160                 165

 tat aaa atg tca gct ttt aag gaa aac tgt gga ata tat ttt cca gaa      578
 Tyr Lys Met Ser Ala Phe Lys Glu Asn Cys Gly Ile Tyr Phe Pro Glu
 170                 175                 180                 185

 ata aac aca gag atc cag gca gat att tac ata gtt gtc ctg aat ctg      626
 Ile Asn Thr Glu Ile Gln Ala Asp Ile Tyr Ile Val Val Leu Asn Leu
                 190                 195                 200

 tga caaa aatggcttcg acagctaaag aatgctggga aaaattcttc tgttaattac      683
 






      <210> 383
      <211> 2076
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (902)..(1579)

      <400> 383
 gggccactgt gtgaacacag aaggtgggtt tgtgtgcgag tgtgggccgg gcatgcagct     60

 gtctgccgac cgccacagct gccaagacac tgacgaatgc ctagggactc cctgtcagca    120

 gagatgtaaa aacagcattg gcagctacaa gtgttcctgt cgaactggct tccaccttca    180

 tggcaaccgg cactcctgtg tagatacacc ccaaggattc ctctctgctc acccattttc    240

 ttggctgcct ttgctcccct tgatgtaaac gagtgtcgga ggccattgga gaggcgagtc    300

 tgtcaccatt cctgccacaa caccgtgggc agcttcctat gcacatgccg acctggcttc    360

 aggctccgag ctgaccgcgt gtcctgtgaa gctttcccga aagccgtgct ggccccatct    420

 gccatcctgc aaccccggca acacccgtcc aagatgcttc tgttgcttcc tgaggccggc    480

 cggcctgccc tgtccccagg acatagccct ccttctgggg ctccagggcc cccagccgga    540

 gtcaggacca cccgcctgcc atctcccacc ccacgactac ccacatcctc cccttctgcc    600

 cctgtgtggc tgctgtccac cctgctggcc accccagtgc ctactgcctc cctgctgggg    660

 aacctcagac ccccctcact ccttcagggg gaggtgatgg ggaccccttc ctcacccagg    720

 ggccctgagt ccccccgact ggcagcaggg ccctctccct gctggcacct gggagccatg    780

 catgaatcaa ggagtcgctg gacagagcct gggtgttccc agtgctggtg cgaggacggg    840

 aaggtgacct gtgaaaaggt gaggtgtgaa gctgcttgtt cccacccaat tccctccaga    900

 g    atg gtg ggt gct gcc cat cgt gca cag gct gtt ttc aca gtg gtg     946
      Met Val Gly Ala Ala His Arg Ala Gln Ala Val Phe Thr Val Val
        1               5                  10                  15

 tcg tcc gag ctg aag ggg atg tgt ttt cac ctc cca atg aga act gca      994
 Ser Ser Glu Leu Lys Gly Met Cys Phe His Leu Pro Met Arg Thr Ala
                  20                  25                  30

 ccg tct gtg tct gtc tgg ctg gaa acg tgt cct gca tct ctc ctg agt     1042
 Pro Ser Val Ser Val Trp Leu Glu Thr Cys Pro Ala Ser Leu Leu Ser
              35                  40                  45

 gtc ctt ctg gcc cct gtc aga ccc ccc cca cag acg gat tgc tgt act     1090
 Val Leu Leu Ala Pro Val Arg Pro Pro Pro Gln Thr Asp Cys Cys Thr
          50                  55                  60

 tgt gtt cca gtg aga tgc tat ttc cac ggc cgg tgg tac gca gac ggg     1138
 Cys Val Pro Val Arg Cys Tyr Phe His Gly Arg Trp Tyr Ala Asp Gly
      65                  70                  75

 gct gtg ttc agt ggg ggt ggt gac gag tgt acc acc tgt gtt tgc cag     1186
 Ala Val Phe Ser Gly Gly Gly Asp Glu Cys Thr Thr Cys Val Cys Gln
  80                  85                  90                  95

 aat ggg gag gtg gag tgc tcc ttc atg ccc tgc cct gag ctg gcc tgc     1234
 Asn Gly Glu Val Glu Cys Ser Phe Met Pro Cys Pro Glu Leu Ala Cys
                 100                 105                 110

 ccc cga gaa gag tgg cgg ctg ggc cct ggg cag tgt tgc ttc acc tgc     1282
 Pro Arg Glu Glu Trp Arg Leu Gly Pro Gly Gln Cys Cys Phe Thr Cys
             115                 120                 125

 cag gag ccc aca ccc tcg aca ggc tgc tct ctt gac gac aac ggg gtt     1330
 Gln Glu Pro Thr Pro Ser Thr Gly Cys Ser Leu Asp Asp Asn Gly Val
         130                 135                 140

 gag ttt ccg att gga cag atc tgg tcg cct ggt gac ccc tgt gag tta     1378
 Glu Phe Pro Ile Gly Gln Ile Trp Ser Pro Gly Asp Pro Cys Glu Leu
     145                 150                 155

 tgc atc tgc cag ggc ggg gag gca ggg gcc ggt gtc tcc ggt ggg gtc     1426
 Cys Ile Cys Gln Gly Gly Glu Ala Gly Ala Gly Val Ser Gly Gly Val
 160                 165                 170                 175

 ttg gtg aag ttc ctc ctt cct cca ggc aga tgg ctc ggt gag ctg caa     1474
 Leu Val Lys Phe Leu Leu Pro Pro Gly Arg Trp Leu Gly Glu Leu Gln
                 180                 185                 190

 gag gac aga ctg tgt gga ctc ctg ccc tca ccc gat ccg gat ccc tgg     1522
 Glu Asp Arg Leu Cys Gly Leu Leu Pro Ser Pro Asp Pro Asp Pro Trp
             195                 200                 205

 aca gtg ctg ccc aga ctg ttc agc agg ctg cac cta cac agg cag aat     1570
 Thr Val Leu Pro Arg Leu Phe Ser Arg Leu His Leu His Arg Gln Asn
         210                 215                 220

 ctt cta taa caacgag accttcccgt ctgtgctgga cccatgtctg agctgcatct     1626
 Leu Leu 
     225

 gcctgctggg ctcagcggcc tgttcccccg tggactgccc catcacctgt acctaccctt   1686

 tccaccctga cggggagtgc tgccccgtgt gccgagactg caactacgag ggaaggaagg   1746

 tggcgaatgg ccaggtgttc accttggatg atgaaccctg cacccggtgc acgtgccagc   1806

 tgggagaggt gagctgtgag aaggttccct gccagcgggc ctgtgccgac cctgccctgc   1866

 ttcctgggga ctgctgctct tcctgtccag attccctgtc tcctctggaa gaaaagcagg   1926

 ggctctcccc tcacggaaat gtggcattca gcaaagctgg tcggagcctg catggagaca   1986

 ctgaggcccc tgtcaactgt agctcctgtc ctgggccccc gacagcatca ccctcgaggc   2046

 cggtgcttca actcctccag ctgtattcgc                                    2076




      <210> 384
      <211> 2802
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (96)..(1649)

      <400> 384
 ttccgctcca ggaaggcgag gtcggatctg agatatctcc cagggaggtt cacttccccg     60

 gaactctgcc ttttcccaga aggaggaggg gaaaa   atg acc aag ttc cag gag     113
                                          Met Thr Lys Phe Gln Glu
                                            1               5

 gca gtg aca ttc aag gat gtg gct gtg gtc ttc act gag gag gag ctg      161
 Ala Val Thr Phe Lys Asp Val Ala Val Val Phe Thr Glu Glu Glu Leu
              10                  15                  20

 ggg ctg ctg gac cct gcc cag agg aag ctg tac cga gat gtg atg ctg      209
 Gly Leu Leu Asp Pro Ala Gln Arg Lys Leu Tyr Arg Asp Val Met Leu
          25                  30                  35

 gag aac ttc agg aac ctg ctc tca gtg gga cat cag tcc ttc aaa cca      257
 Glu Asn Phe Arg Asn Leu Leu Ser Val Gly His Gln Ser Phe Lys Pro
      40                  45                  50

 gat atg ata tcc cag ttg gag agg gaa gaa aag ctt tgg atg aag gag      305
 Asp Met Ile Ser Gln Leu Glu Arg Glu Glu Lys Leu Trp Met Lys Glu
  55                  60                  65                  70

 ctt caa acc caa aga ggt aag cat tca gga gac agg aat caa aat gag      353
 Leu Gln Thr Gln Arg Gly Lys His Ser Gly Asp Arg Asn Gln Asn Glu
                  75                  80                  85

 atg gca act ctt cac aaa gca gga tta agg tgc ttt tca ctg gga gag      401
 Met Ala Thr Leu His Lys Ala Gly Leu Arg Cys Phe Ser Leu Gly Glu
              90                  95                 100

 ctt tca tgc tgg caa atc aag aga cac att gcg agc aaa tta gcc aga      449
 Leu Ser Cys Trp Gln Ile Lys Arg His Ile Ala Ser Lys Leu Ala Arg
         105                 110                 115

 agt caa gac tcc acg ata aat att gaa gga aag agc tct cag ttc ccc      497
 Ser Gln Asp Ser Thr Ile Asn Ile Glu Gly Lys Ser Ser Gln Phe Pro
     120                 125                 130

 aag cac cat gat tcc ccc tgt caa gtg gga gca gga gaa tct att caa      545
 Lys His His Asp Ser Pro Cys Gln Val Gly Ala Gly Glu Ser Ile Gln
 135                 140                 145                 150

 gct tct gtg gat gac aac tgt cta gtg aat cac ata ggg gat cat tcc      593
 Ala Ser Val Asp Asp Asn Cys Leu Val Asn His Ile Gly Asp His Ser
                 155                 160                 165

 agt atc att gaa aat caa gaa ttt cca act ggg aaa gtt ccg aat tct      641
 Ser Ile Ile Glu Asn Gln Glu Phe Pro Thr Gly Lys Val Pro Asn Ser
             170                 175                 180

 tgg agt aaa ata tat ctg aat gag aca cag aat tat cag aga agt tgt      689
 Trp Ser Lys Ile Tyr Leu Asn Glu Thr Gln Asn Tyr Gln Arg Ser Cys
         185                 190                 195

 aag cag act cag atg aaa aac aaa cta tgt ata ttt gct cca tat gtt      737
 Lys Gln Thr Gln Met Lys Asn Lys Leu Cys Ile Phe Ala Pro Tyr Val
     200                 205                 210

 gac att ttc agt tgt att tca cac cac cat gat gat aat ata gtg cac      785
 Asp Ile Phe Ser Cys Ile Ser His His His Asp Asp Asn Ile Val His
 215                 220                 225                 230

 aaa aga gat aaa gtt cat agc aat agt gat tgt ggt aaa gat acc cta      833
 Lys Arg Asp Lys Val His Ser Asn Ser Asp Cys Gly Lys Asp Thr Leu
                 235                 240                 245

 aag gta tca cct ctt acc cag cgt agt att cac aca gga cag aaa acc      881
 Lys Val Ser Pro Leu Thr Gln Arg Ser Ile His Thr Gly Gln Lys Thr
             250                 255                 260

 tac cag ggt aat gaa tgt gaa gaa gcc ttc aat gat agc tcc agt ctt      929
 Tyr Gln Gly Asn Glu Cys Glu Glu Ala Phe Asn Asp Ser Ser Ser Leu
         265                 270                 275

 gaa ctt cat aaa cag gta cac ttg gga aag aag tct cca gcg tgt agt      977
 Glu Leu His Lys Gln Val His Leu Gly Lys Lys Ser Pro Ala Cys Ser
     280                 285                 290

 aca cat gag aag gac acc agt tat agc tca ggt att cct gtt caa caa     1025
 Thr His Glu Lys Asp Thr Ser Tyr Ser Ser Gly Ile Pro Val Gln Gln
 295                 300                 305                 310

 agt gtt cgt act ggg aaa aaa cgc tat tgg tgt cat gaa tgt ggt aaa     1073
 Ser Val Arg Thr Gly Lys Lys Arg Tyr Trp Cys His Glu Cys Gly Lys
                 315                 320                 325

 ggt ttc agt cag agc tca aat ctg caa act cat cag aga gtc cac aca     1121
 Gly Phe Ser Gln Ser Ser Asn Leu Gln Thr His Gln Arg Val His Thr
             330                 335                 340

 ggg gag aaa ccc tat aca tgc cac gag tgt ggt aag agc ttt aat cag     1169
 Gly Glu Lys Pro Tyr Thr Cys His Glu Cys Gly Lys Ser Phe Asn Gln
         345                 350                 355

 agc tca cat ctt tat gct cat ttg cct att cac aca gga gag aaa ccc     1217
 Ser Ser His Leu Tyr Ala His Leu Pro Ile His Thr Gly Glu Lys Pro
     360                 365                 370

 tat aga tgt gac agt tgt ggg aag ggc ttc agt cgt agc aca gat ctt     1265
 Tyr Arg Cys Asp Ser Cys Gly Lys Gly Phe Ser Arg Ser Thr Asp Leu
 375                 380                 385                 390

 aac att cat tgc aga gtt cac act gga gag aaa cct tat aaa tgt gag     1313
 Asn Ile His Cys Arg Val His Thr Gly Glu Lys Pro Tyr Lys Cys Glu
                 395                 400                 405

 gtg tgt ggg aag ggc ttc act cag aga tca cat ctt cag gcc cat gaa     1361
 Val Cys Gly Lys Gly Phe Thr Gln Arg Ser His Leu Gln Ala His Glu
             410                 415                 420

 aga att cac act gga gag aaa cca tat aaa tgt ggg gat tgt ggt aaa     1409
 Arg Ile His Thr Gly Glu Lys Pro Tyr Lys Cys Gly Asp Cys Gly Lys
         425                 430                 435

 cgc ttt agt tgt agc tca aat ctt cat acc cat cag aga gtc cac act     1457
 Arg Phe Ser Cys Ser Ser Asn Leu His Thr His Gln Arg Val His Thr
     440                 445                 450

 gaa gaa aaa cca tac aaa tgt gat gag tgt ggt aag tgc ttt agt ttg     1505
 Glu Glu Lys Pro Tyr Lys Cys Asp Glu Cys Gly Lys Cys Phe Ser Leu
 455                 460                 465                 470

 agc ttt aat ctt cat agt cat caa cga gtc cac aca gga gaa aaa cca     1553
 Ser Phe Asn Leu His Ser His Gln Arg Val His Thr Gly Glu Lys Pro
                 475                 480                 485

 tat aaa tgt gaa gag tgt ggt aag ggt ttt agt tca gcc tca agt ttc     1601
 Tyr Lys Cys Glu Glu Cys Gly Lys Gly Phe Ser Ser Ala Ser Ser Phe
             490                 495                 500

 cag agc cat cag tca gcc aga ggt caa atc ttc aag tcc atc aga taa     1649
 Gln Ser His Gln Ser Ala Arg Gly Gln Ile Phe Lys Ser Ile Arg 
         505                 510                 515

 ttcacactgg agagaaacca tttaaatgtg aggaatgtgg gaaagaattc agttggagtg   1709

 ctggtctcag tgcccatcag agggtccaca caggagagaa accctatacg tgtcagcagt   1769

 gtgggaaggg cttcagtcag gcctcacatt ttcacacaca ccagagagtc cacactggag   1829

 agaggcctta catatgtgat gtctgttgta agggcttcag tcagaggtca catctcatct   1889

 accatcagag agtccacact ggagggaatc tgtagaaatg agaggtgtgg ttcagccttc   1949

 agttagagct cacatctttg tctccgttgg gaagtccatg ctgatgattg tgaaaagttc   2009

 ctttaaaact agaagcttca aagaatcttg acaggaaaga agtctctcaa atgctgtgtt   2069

 ttagacttgg ttaggacatg aattctttac aaacgtcata tttcacagat gcgagaaaac   2129

 tttgttctgt aaatatgatc agtgtttata tcagagtacc aggtgtcccg gttctcaaga   2189

 tgtaacacag cagaaaagtc ttgtcggagt ctgcacagga gagaggcctt cctttaacaa   2249

 aagtatgatt gacagaaaaa atggatgtca actaaaatgt aacctctatg taaggaggtg   2309

 tttttcacca ctctatctct accatgtaga attgtgcttg gctcataata gggcccagca   2369

 attactgaag aaagtgaaga aaatacctat aattaggaca aatacttgaa aattctagtc   2429

 tgttttctac tctaaattta tattaattta tattcaaaag gaatcctgca agtagcctta   2489

 ataacgttag tttcagtaag tactgaaaag tatataatac tgccatccat actaacacaa   2549

 atttggaaaa aagacatgaa tggctcccat ccttcagcct tagttctttg tacagtgtat   2609

 catcagttgt gtacagtatg atttttagtg tcagtttata gactgaacaa tactgttttt   2669

 atctaatgtg accctgcaat ttacatgatt agaatttttg gacactaagc tgtactgtaa   2729

 ctctgaaagt gttaaaagta gttactgatg acaaaaagtt tcttagtaaa cttgaattgt   2789

 taaaaaaaaa aaa                                                      2802




      <210> 385
      <211> 2547
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (210)..(1859)

      <400> 385
 cggaattccc gggtcgaccc acgcgtccgc attgtcctgg cagagcggcg agccggtgag     60

 tgtggctgcg gggtcgcgcc caccctctac ctgtgccggg ggccggaacc tggccccggg    120

 gagggcgcgg cctcggggag acggcgtgca ggcccagcac tgttggtcac cgcaggcctg    180

 tcttcctatt caccgtgggc agcagaggg  atg gct gct cag ctg ctg act gat     233
                                  Met Ala Ala Gln Leu Leu Thr Asp
                                    1               5

 gag gca ctg gaa tca gtg acg ttc agg gat gtg act gtg gac ttc acc      281
 Glu Ala Leu Glu Ser Val Thr Phe Arg Asp Val Thr Val Asp Phe Thr
      10                  15                  20

 cag gag gag tgg cag cag ctg gag cct gcc cag aag gac ctg tac agg      329
 Gln Glu Glu Trp Gln Gln Leu Glu Pro Ala Gln Lys Asp Leu Tyr Arg
  25                  30                  35                  40

 gat gtc atg ctg gag aac tac agg aac ctg gtc tca ctg gac tgg gag      377
 Asp Val Met Leu Glu Asn Tyr Arg Asn Leu Val Ser Leu Asp Trp Glu
                  45                  50                  55

 act aga cct gaa atg aaa gag ttg gat cca aag aat gac att tcg gaa      425
 Thr Arg Pro Glu Met Lys Glu Leu Asp Pro Lys Asn Asp Ile Ser Glu
              60                  65                  70

 gac aag ctc tcc gtt gtt ggg gag gcc acg ggg gga ccc acg agg aat      473
 Asp Lys Leu Ser Val Val Gly Glu Ala Thr Gly Gly Pro Thr Arg Asn
          75                  80                  85

 ggt gcc agg ggt cct ggc tca gaa gga gtg tgg gaa cca ggc agc tgg      521
 Gly Ala Arg Gly Pro Gly Ser Glu Gly Val Trp Glu Pro Gly Ser Trp
      90                  95                 100

 cca gag agg ccg cgg gga gat gca ggt gca gag tgg gag cca ttg gga      569
 Pro Glu Arg Pro Arg Gly Asp Ala Gly Ala Glu Trp Glu Pro Leu Gly
 105                 110                 115                 120

 att ccc cag ggg aac aaa ctc tta ggg ggc tca gta ccc gca tgt cat      617
 Ile Pro Gln Gly Asn Lys Leu Leu Gly Gly Ser Val Pro Ala Cys His
                 125                 130                 135

 gaa ctg aag gca ttt gcc aac caa ggc tgt gtc ctg gtc cca cca cgg      665
 Glu Leu Lys Ala Phe Ala Asn Gln Gly Cys Val Leu Val Pro Pro Arg
             140                 145                 150

 ctg gac gac ccc aca gaa aag ggg gcc tgt cca ccc gta agg cgt ggc      713
 Leu Asp Asp Pro Thr Glu Lys Gly Ala Cys Pro Pro Val Arg Arg Gly
         155                 160                 165

 aag aac ttc tcc agc act tca gac ctc agt aag ccc ccc atg ccc tgc      761
 Lys Asn Phe Ser Ser Thr Ser Asp Leu Ser Lys Pro Pro Met Pro Cys
     170                 175                 180

 gag gag aag aaa acc tac gac tgc agc gag tgt ggc aag gcc ttt agc      809
 Glu Glu Lys Lys Thr Tyr Asp Cys Ser Glu Cys Gly Lys Ala Phe Ser
 185                 190                 195                 200

 cga agc tcg tcc ctg ata aag cac caa agg atc cac acg gga gaa aag      857
 Arg Ser Ser Ser Leu Ile Lys His Gln Arg Ile His Thr Gly Glu Lys
                 205                 210                 215

 ccg ttt gag tgt gac acc tgt ggg aag cac ttc atc gag cgc tcg tcc      905
 Pro Phe Glu Cys Asp Thr Cys Gly Lys His Phe Ile Glu Arg Ser Ser
             220                 225                 230

 ctc acc atc cac cag cgg gtg cac acg ggc gag aag ccc tat gcc tgc      953
 Leu Thr Ile His Gln Arg Val His Thr Gly Glu Lys Pro Tyr Ala Cys
         235                 240                 245

 ggg gac tgc ggc aag gcc ttc agc cag cgc atg aac ctc act gtg cac     1001
 Gly Asp Cys Gly Lys Ala Phe Ser Gln Arg Met Asn Leu Thr Val His
     250                 255                 260

 cag cgc acg cac acg ggc gag aag ccg tat gtg tgc gac gtg tgt ggc     1049
 Gln Arg Thr His Thr Gly Glu Lys Pro Tyr Val Cys Asp Val Cys Gly
 265                 270                 275                 280

 aag gcc ttc cgg aag act tcc tct ctc acc cag cac gag cgg atc cac     1097
 Lys Ala Phe Arg Lys Thr Ser Ser Leu Thr Gln His Glu Arg Ile His
                 285                 290                 295

 acg ggg gag aag ccc tac gcg tgc ggg gac tgc ggc aag gcc ttc agc     1145
 Thr Gly Glu Lys Pro Tyr Ala Cys Gly Asp Cys Gly Lys Ala Phe Ser
             300                 305                 310

 cag aac atg cac ctc atc gtg cac cag cgc acg cac acc ggg gag aag     1193
 Gln Asn Met His Leu Ile Val His Gln Arg Thr His Thr Gly Glu Lys
         315                 320                 325

 ccg tac gtg tgc ccc gag tgc ggg cga gcc ttc agc cag aac atg cac     1241
 Pro Tyr Val Cys Pro Glu Cys Gly Arg Ala Phe Ser Gln Asn Met His
     330                 335                 340

 ctg acc gag cac cag cgc acg cac acc ggg gag aag ccg tac gcc tgc     1289
 Leu Thr Glu His Gln Arg Thr His Thr Gly Glu Lys Pro Tyr Ala Cys
 345                 350                 355                 360

 aag gag tgc ggc aag gcc ttc aac aag agc tcc tcg ctc acc ctg cac     1337
 Lys Glu Cys Gly Lys Ala Phe Asn Lys Ser Ser Ser Leu Thr Leu His
                 365                 370                 375

 cag agg aac cac acc ggc gag aag ccc tac gtg tgc ggc gag tgc ggc     1385
 Gln Arg Asn His Thr Gly Glu Lys Pro Tyr Val Cys Gly Glu Cys Gly
             380                 385                 390

 aag gcc ttc agc cag agc tcc tac ctc atc cag cac cag cgc ttc cac     1433
 Lys Ala Phe Ser Gln Ser Ser Tyr Leu Ile Gln His Gln Arg Phe His
         395                 400                 405

 atc ggc gtg aag ccg ttc gag tgc agc gag tgc ggc aag gcc ttc agc     1481
 Ile Gly Val Lys Pro Phe Glu Cys Ser Glu Cys Gly Lys Ala Phe Ser
     410                 415                 420

 aag aac tcc tcg ctc acg cag cac cag cgc atc cac acc ggc gag aag     1529
 Lys Asn Ser Ser Leu Thr Gln His Gln Arg Ile His Thr Gly Glu Lys
 425                 430                 435                 440

 ccc tac gag tgc tac atc tgc aag aag cac ttc acg ggg cgc tcg tcc     1577
 Pro Tyr Glu Cys Tyr Ile Cys Lys Lys His Phe Thr Gly Arg Ser Ser
                 445                 450                 455

 ctc atc gtg cac cag atc gtg cac acc ggg gag aag ccc tac gtg tgc     1625
 Leu Ile Val His Gln Ile Val His Thr Gly Glu Lys Pro Tyr Val Cys
             460                 465                 470

 ggc gag tgc ggc aag gcc ttc agc cag agc gcc tac ctc atc gag cac     1673
 Gly Glu Cys Gly Lys Ala Phe Ser Gln Ser Ala Tyr Leu Ile Glu His
         475                 480                 485

 cag cgg atc cac acc ggc gag aag ccg tac agg tgc ggc cag tgc ggg     1721
 Gln Arg Ile His Thr Gly Glu Lys Pro Tyr Arg Cys Gly Gln Cys Gly
     490                 495                 500

 aag tcc ttc atc aag aac tcc tcc ctc act gtg cac cag cgg atc cac     1769
 Lys Ser Phe Ile Lys Asn Ser Ser Leu Thr Val His Gln Arg Ile His
 505                 510                 515                 520

 acg ggc gag aag ccc tac cga tgc ggc gag tgc ggg aag acc ttc agc     1817
 Thr Gly Glu Lys Pro Tyr Arg Cys Gly Glu Cys Gly Lys Thr Phe Ser
                 525                 530                 535

 cgc aac acg aac ctg acg cgc cac ctg cgg att cac acc tga gcgcctc     1866
 Arg Asn Thr Asn Leu Thr Arg His Leu Arg Ile His Thr 
             540                 545

 tgtgcagggc tctcactggc ggtgcccagg acggacgcca gatggctgcg cgctttgtca   1926

 gcagtgctgt gagaagttct cccctggggt ggggactcgg ggtcagggga gctcaggaat   1986

 gtggggttgt ggaggggctg gctgatcaca catgccccct ccttactgag cctcagaaag   2046

 caagcccctc ggtgtctgac gtatctgggg acacttcaag gttcactgta gctgagccat   2106

 ggccgctggt aacagacatc agggttccag actagccctc ttgagtaact gtcctagagc   2166

 tgggacaggt cacgcctgcc tccacatctc tgtttcttca gcgggaaagt ggagctggtg   2226

 gaggggaggg aggagacatc tccctctttg tcagatacat cctggagtcc agatgcagct   2286

 tgtcaccatc tgcattttct ccgtgggttg ggagcgtgag ggccttccta tccctccacc   2346

 caccgtttcc ctgcagtgca cgctggcagc caccaagcta ggaagtggca ggagtttgcc   2406

 ggttgtttgt gaggggaaaa attttttttt cagagttagc aaataacagt aactactgct   2466

 ttgaatgcca aagtttctta gagtggtctg ttacgttttt taaaaataaa acttttaatt   2526

 aagggagaaa aaaaaaaaaa a                                             2547




      <210> 386
      <211> 657
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (1)..(657)

      <400> 386
  atg atc tca gtg gtc gtg atc aga atg ctg gtg gag atc cac aca gtc      48
  Met Ile Ser Val Val Val Ile Arg Met Leu Val Glu Ile His Thr Val
    1               5                  10                  15

 aaa gcc att ctc gac ccg cct gtc ttc cat act ggc caa ata ggt aga       96
 Lys Ala Ile Leu Asp Pro Pro Val Phe His Thr Gly Gln Ile Gly Arg
              20                  25                  30

 ggc acc tct aat ggc ttc cag ttg gcc cac aat agt ggc cct cac ccc      144
 Gly Thr Ser Asn Gly Phe Gln Leu Ala His Asn Ser Gly Pro His Pro
          35                  40                  45

 aca cgt cag gaa acc aat gtg ggg act cag ccg gtg gct gag tac agt      192
 Thr Arg Gln Glu Thr Asn Val Gly Thr Gln Pro Val Ala Glu Tyr Ser
      50                  55                  60

 tgt gca cag cat gag gat gct ttg gtc aag aac ggg tac atg gat gcc      240
 Cys Ala Gln His Glu Asp Ala Leu Val Lys Asn Gly Tyr Met Asp Ala
  65                  70                  75                  80

 agc ctc aca ccg tgg ctc ttc cgg aag gtg tgg ggc cag gcc tgc tgc      288
 Ser Leu Thr Pro Trp Leu Phe Arg Lys Val Trp Gly Gln Ala Cys Cys
                  85                  90                  95

 act tac tgc ttt ggg cta atg att cag aga gtg aag ggt gct ttc tcc      336
 Thr Tyr Cys Phe Gly Leu Met Ile Gln Arg Val Lys Gly Ala Phe Ser
             100                 105                 110

 cca gag gaa gga gcg aag gcc ttt gca gga gat gac aca ctg acg aag      384
 Pro Glu Glu Gly Ala Lys Ala Phe Ala Gly Asp Asp Thr Leu Thr Lys
         115                 120                 125

 gtt tcc cat gcc ctc tcc aag aaa act gat gga caa cgg ggc tgc atc      432
 Val Ser His Ala Leu Ser Lys Lys Thr Asp Gly Gln Arg Gly Cys Ile
     130                 135                 140

 ctg ggc ggg ggc tta cct ggg aac cac gtg gga cca ggt ccg gag aac      480
 Leu Gly Gly Gly Leu Pro Gly Asn His Val Gly Pro Gly Pro Glu Asn
 145                 150                 155                 160

 cat cct cta gcc agc tcg tct tgg caa gtg tcg tcc aac cca gtg cta      528
 His Pro Leu Ala Ser Ser Ser Trp Gln Val Ser Ser Asn Pro Val Leu
                 165                 170                 175

 gct gat aga acc ttc tgc aac gat ggg aat gtt ctg tac ctg gat aac      576
 Ala Asp Arg Thr Phe Cys Asn Asp Gly Asn Val Leu Tyr Leu Asp Asn
             180                 185                 190

 ccc ctg gca cag atg act act ggg tac tgg aaa tgt ggc cac aag gaa      624
 Pro Leu Ala Gln Met Thr Thr Gly Tyr Trp Lys Cys Gly His Lys Glu
         195                 200                 205

 cca aat ttt tca ttg tgt ttc atc gta att taa                          657
 Pro Asn Phe Ser Leu Cys Phe Ile Val Ile 
     210                 215





      <210> 387
      <211> 889
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (179)..(538)

      <220>
      <221> misc_feature
      <222> (1)...(889)
      <223> n = a,t,c or g

      <400> 387
 gttggacgag gctggaagaa gggagtgaga ctgctcagag aggcaggatt cctgctgact     60

 ccagggggac acctggcacc tcagcttcct ttcccacttc tccaggctgc atggaggggt    120

 gccgggcagg ggcctcctgg aagggaacct cctgcagcct caagcaccag gtcatgac      178                                                                 
 atg aca tct atc cct ttc cca ggt gac cga ctc ctg cag gtg gat gga      226
 Met Thr Ser Ile Pro Phe Pro Gly Asp Arg Leu Leu Gln Val Asp Gly
   1               5                  10                  15

 gtg att ctg tgc ggc ctc acc cac aag cag gct gtg cag tgc ctg aag      274
 Val Ile Leu Cys Gly Leu Thr His Lys Gln Ala Val Gln Cys Leu Lys
              20                  25                  30

 ggt cct ggg cag gtt gca aga ctg gtc tta gag aga aga gtc ccc agg      322
 Gly Pro Gly Gln Val Ala Arg Leu Val Leu Glu Arg Arg Val Pro Arg
          35                  40                  45

 agt aca cag cag tgt cct tct gct aat gac agc atg gga gat gaa cgc      370
 Ser Thr Gln Gln Cys Pro Ser Ala Asn Asp Ser Met Gly Asp Glu Arg
      50                  55                  60

 acg gct gtt tcc ttg gta aca gcc ttg cct ggc agg cct tcg agc tgt      418
 Thr Ala Val Ser Leu Val Thr Ala Leu Pro Gly Arg Pro Ser Ser Cys
  65                  70                  75                  80

 gtc tcg gtg aca gat ggt cct aag ttt gaa gtc aaa cta aaa aag aat      466
 Val Ser Val Thr Asp Gly Pro Lys Phe Glu Val Lys Leu Lys Lys Asn
                  85                  90                  95

 gcc aat ggt ttg gga ttc agt ttc gtg cag atg gag aaa gag agc tgc      514
 Ala Asn Gly Leu Gly Phe Ser Phe Val Gln Met Glu Lys Glu Ser Cys
             100                 105                 110

 agc cat ctc aaa gtg atc ttg tga ggattaagag gctctttccg gggcagccag     568
 Ser His Leu Lys Val Ile Leu 
         115

 ctgaggagaa tggggcnnnn cgagctggtg acattatcct ggccgtgaat ggaaggtcca    628

 cggaaggcct catcttccag gaggtgctgc atttactgag aggggcccca caggaagtca    688

 cgctcctcct ttgccgaccc cctccaggtg cgctgcctga gatggagcag gaatggcaga    748

 cacctgaact ctcagctgac aaagaattca ccagggcaac atgtactgac tcatgtacca    808

 gccccatcct ggatcaagag gacagctgga ggacagtgcc tccccagatg caggggaagg    868

 cctgggtctc aggccagagt c                                              889




      <210> 388
      <211> 1983
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (432)..(1847)

      <400> 388
 ggcaggcact gcccgggctg gacgacgtct ggcctggctc ccgtgcgaag tgtgcagctg     60

 gaggagcggc ccagagcgcg cagctagtgg cacatggctg aagacccctg tgtgacatgt    120

 ccactctcct gatgctgtgt ggtgctgtgc tgcatgatgc atgtcccatc ccctgtgtgg    180

 tccctgggcg ctggctgact gccggctggt tccctgcgct gcagtagctc ccctgagcct    240

 ggtgctgcac cggatggctg gcgagatggt cgcgcgctgt cggcctcctg ctgcgcgccc    300

 ttgcagctgc tactgtgtgg gccacctgga cgcccagccc gcggagcgcg gaggccagtg    360

 agctgcgcaa ggaggcggag gcattcctag agaatgtact gtgatagcct caagtgaagc    420

 atggtcccca a atg ctc cca cct cca ctc gat tca gct gat gcc atc aga     470
              Met Leu Pro Pro Pro Leu Asp Ser Ala Asp Ala Ile Arg
                1               5                  10

 gct gtt tca gtg ggt gtc cca gct acc ctg tca gct ggc gtt gtt tgg      518
 Ala Val Ser Val Gly Val Pro Ala Thr Leu Ser Ala Gly Val Val Trp
      15                  20                  25

 acc tgc gcc acc ctg cgc cag atg act cgt ccc cgc tgc ggg gtt aca      566
 Thr Cys Ala Thr Leu Arg Gln Met Thr Arg Pro Arg Cys Gly Val Thr
  30                  35                  40                  45

 gat acc aac agt tat gcg gcc tgg gct gag agg atc agt gac ttg ttt      614
 Asp Thr Asn Ser Tyr Ala Ala Trp Ala Glu Arg Ile Ser Asp Leu Phe
                  50                  55                  60

 gct aga cac cgg acc aaa atg agg cgt aag aaa cgc ttt gca aag caa      662
 Ala Arg His Arg Thr Lys Met Arg Arg Lys Lys Arg Phe Ala Lys Gln
              65                  70                  75

 ggt aac aaa tgg tac aag cag cac ctc tcc tac cgc ctg gtg aac tgg      710
 Gly Asn Lys Trp Tyr Lys Gln His Leu Ser Tyr Arg Leu Val Asn Trp
          80                  85                  90

 cct gag cat ctg ccg gag ccg gca gtt cgg ggc gcc gtg cgc gcc gcc      758
 Pro Glu His Leu Pro Glu Pro Ala Val Arg Gly Ala Val Arg Ala Ala
      95                 100                 105

 ttc cag ttg tgg agc aac gtc tca gcg ctg gag ttc tgg gag gcc cca      806
 Phe Gln Leu Trp Ser Asn Val Ser Ala Leu Glu Phe Trp Glu Ala Pro
 110                 115                 120                 125

 gcc aca ggc ccc gct gac atc cgg ctc acc ttc ttc caa ggg gac cac      854
 Ala Thr Gly Pro Ala Asp Ile Arg Leu Thr Phe Phe Gln Gly Asp His
                 130                 135                 140

 aac gat ggg ctg ggc aat gcc ttt gat ggc cca ggg ggc gcc ctg gcg      902
 Asn Asp Gly Leu Gly Asn Ala Phe Asp Gly Pro Gly Gly Ala Leu Ala
             145                 150                 155

 cac gcc ttc ctg ccc cgc cgc ggc gaa gcg cac ttc gac caa gat gag      950
 His Ala Phe Leu Pro Arg Arg Gly Glu Ala His Phe Asp Gln Asp Glu
         160                 165                 170

 cgc tgg tcc ctg agc cgc cgc cgc ggg cgc aac ctg ttc gtg gtg ctg      998
 Arg Trp Ser Leu Ser Arg Arg Arg Gly Arg Asn Leu Phe Val Val Leu
     175                 180                 185

 gcg cac gag atc ggt cac acg ctt ggc ctc acc cac tcg ccc gcg ccg     1046
 Ala His Glu Ile Gly His Thr Leu Gly Leu Thr His Ser Pro Ala Pro
 190                 195                 200                 205

 cgc gcg ctc atg gcg ccc tac tac aag agg ctg ggc cgc gac gcg ctg     1094
 Arg Ala Leu Met Ala Pro Tyr Tyr Lys Arg Leu Gly Arg Asp Ala Leu
                 210                 215                 220

 ctc agc tgg gac gac gtg ctg gcc gtg cag agc ctg tat ggg aag ccc     1142
 Leu Ser Trp Asp Asp Val Leu Ala Val Gln Ser Leu Tyr Gly Lys Pro
             225                 230                 235

 cta ggg ggc tca gtg gcc gtc cag ctc cca gga aag ctg ttc act gac     1190
 Leu Gly Gly Ser Val Ala Val Gln Leu Pro Gly Lys Leu Phe Thr Asp
         240                 245                 250

 ttt gag acc tgg gac tcc tac agc ccc caa gga agg cgc cct gaa acg     1238
 Phe Glu Thr Trp Asp Ser Tyr Ser Pro Gln Gly Arg Arg Pro Glu Thr
     255                 260                 265

 cag ggc cct aaa tac tgc cac tct tcc ttc gat gcc atc act gta gac     1286
 Gln Gly Pro Lys Tyr Cys His Ser Ser Phe Asp Ala Ile Thr Val Asp
 270                 275                 280                 285

 agg caa cag caa ctg tac att ttt aaa ggg agc cat ttc tgg gag gtg     1334
 Arg Gln Gln Gln Leu Tyr Ile Phe Lys Gly Ser His Phe Trp Glu Val
                 290                 295                 300

 gca gct gat ggc aac gtc tca gag ccc cgt cca ctg cag gaa aga tgg     1382
 Ala Ala Asp Gly Asn Val Ser Glu Pro Arg Pro Leu Gln Glu Arg Trp
             305                 310                 315

 gtc ggg ctg ccc ccc aac att gag gct gcg gca gtg tca ttg aat gat     1430
 Val Gly Leu Pro Pro Asn Ile Glu Ala Ala Ala Val Ser Leu Asn Asp
         320                 325                 330

 gga gat ttc tac ttc ttc aaa ggg ggt cga tgc tgg agg ttc cgg ggc     1478
 Gly Asp Phe Tyr Phe Phe Lys Gly Gly Arg Cys Trp Arg Phe Arg Gly
     335                 340                 345

 ccc aag cca gtg tgg ggt ctc cca cag ctg tgc cgg gca ggg ggc ctg     1526
 Pro Lys Pro Val Trp Gly Leu Pro Gln Leu Cys Arg Ala Gly Gly Leu
 350                 355                 360                 365

 ccc cgc cat cct gac gcc gcc ctc ttc ttc cct cct ctg cgc cgc ctc     1574
 Pro Arg His Pro Asp Ala Ala Leu Phe Phe Pro Pro Leu Arg Arg Leu
                 370                 375                 380

 atc ctc ttc aag ggt gcc cgc tac tac gtg ctg gcc cga ggg gga ctg     1622
 Ile Leu Phe Lys Gly Ala Arg Tyr Tyr Val Leu Ala Arg Gly Gly Leu
             385                 390                 395

 caa gtg gag ccc tac tac ccc cga agt ttg cag gac tgg gga ggc atc     1670
 Gln Val Glu Pro Tyr Tyr Pro Arg Ser Leu Gln Asp Trp Gly Gly Ile
         400                 405                 410

 cct gag gag gtc agc ggc gcc ctg ccg agg ccc gat ggc tcc atc atc     1718
 Pro Glu Glu Val Ser Gly Ala Leu Pro Arg Pro Asp Gly Ser Ile Ile
     415                 420                 425

 ttc ttc cga gat gac cgc tac tgg cgc ctc gac cag gcc aaa ctg cag     1766
 Phe Phe Arg Asp Asp Arg Tyr Trp Arg Leu Asp Gln Ala Lys Leu Gln
 430                 435                 440                 445

 gca acc acc tcg ggc cgt tgg gcc acc gag ctg ccc tgg atg ggc tgc     1814
 Ala Thr Thr Ser Gly Arg Trp Ala Thr Glu Leu Pro Trp Met Gly Cys
                 450                 455                 460

 tgg cat gcc aac tcg ggg agc gcc ctg ttt tga aggcacct cctcacctca     1865
 Trp His Ala Asn Ser Gly Ser Ala Leu Phe 
             465                 470

 gaaactggtg gtgctttcag ggcaaaatca tgttccccac ccccggggca gaaccccttt   1925

 tagaagcctt tgagtccctt tgcagaagac cgggcagcaa agcctcaaaa aaaaaaaa     1983




      <210> 389
      <211> 461
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (141)..(287)

      <400> 389
 accggcccgg aattctcggg tcgacgattt cgtagtggct gccacctgct gcagtctaca     60

 cagcttcggg aagaggaaag gaacctcaga ccttccagat cgcttcctct cgcaacaaac    120

 tatttgtcgc aggaataaag    atg gct gct gaa cca gta gaa gac aat tgc     170
                          Met Ala Ala Glu Pro Val Glu Asp Asn Cys
                            1               5                  10

 atc aac ttt gtg gca atg aaa ttt att gac aat acg ctt tac ttt ata      218
 Ile Asn Phe Val Ala Met Lys Phe Ile Asp Asn Thr Leu Tyr Phe Ile
                  15                  20                  25

 ggt aag gct aat gcc ata gaa caa ata cca ggt tca gat aaa tct att      266
 Gly Lys Ala Asn Ala Ile Glu Gln Ile Pro Gly Ser Asp Lys Ser Ile
              30                  35                  40

 caa tta gaa aag atg ttg tga gg tgaactatta agtgactctt tttgtcacca      319
 Gln Leu Glu Lys Met Leu 
          45

 aatttcactg taatattaat ggctcttaaa aaaatagtgg acctctagaa attaaccaca    379

 acatgtccaa ggtctcagca ccttgtcaca ccacgtgtcc tggcacttta atcagcagta    439

 gctcactctc cagttggcag ta                                             461




      <210> 390
      <211> 696
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (1)..(696)

      <400> 390
  atg tcg ctc tgg acg cgt gca cct gct ctc gca atc acc gac tgc ggt      48
  Met Ser Leu Trp Thr Arg Ala Pro Ala Leu Ala Ile Thr Asp Cys Gly
    1               5                  10                  15

 gat ctg aaa gta gag atg atg gca ggg ggg act cag atc aca ccc ctg       96
 Asp Leu Lys Val Glu Met Met Ala Gly Gly Thr Gln Ile Thr Pro Leu
              20                  25                  30

 aat gac aat gtc acc ata ttc tgc aat atc ttt tat tcc caa ccc ctc      144
 Asn Asp Asn Val Thr Ile Phe Cys Asn Ile Phe Tyr Ser Gln Pro Leu
          35                  40                  45

 aac atc acg tct atg ggt atc acc tgg ttt tgg aag agt ctg acg ttt      192
 Asn Ile Thr Ser Met Gly Ile Thr Trp Phe Trp Lys Ser Leu Thr Phe
      50                  55                  60

 gac aaa gaa gtc aaa gtc ttt gaa ttt ttt gga gat cac caa gag gca      240
 Asp Lys Glu Val Lys Val Phe Glu Phe Phe Gly Asp His Gln Glu Ala
  65                  70                  75                  80

 ttc cga cct gga gcc att gtg tct cca tgg agg ctg aag agt ggg gac      288
 Phe Arg Pro Gly Ala Ile Val Ser Pro Trp Arg Leu Lys Ser Gly Asp
                  85                  90                  95

 gcc tca ctg cgg ctg cct gga atc cag ctg gag gaa gca gga gag tac      336
 Ala Ser Leu Arg Leu Pro Gly Ile Gln Leu Glu Glu Ala Gly Glu Tyr
             100                 105                 110

 cga tgt gag gtg gtg gtc acc cct ctg aag gca cag gga aca gtc cag      384
 Arg Cys Glu Val Val Val Thr Pro Leu Lys Ala Gln Gly Thr Val Gln
         115                 120                 125

 ctt gaa gtt gtg gag att tct gag gat gtc atc act ggt ccc acc atc      432
 Leu Glu Val Val Glu Ile Ser Glu Asp Val Ile Thr Gly Pro Thr Ile
     130                 135                 140

 aag aat atg gat ggc aca ttt aat gtc act agc tgc ttg aag ctg aac      480
 Lys Asn Met Asp Gly Thr Phe Asn Val Thr Ser Cys Leu Lys Leu Asn
 145                 150                 155                 160

 tcc tct cag gaa gac cct ggg act gtc tac cag tgt gtg gta cgg cat      528
 Ser Ser Gln Glu Asp Pro Gly Thr Val Tyr Gln Cys Val Val Arg His
                 165                 170                 175

 gcg tcc ttg cat acc ccc ttg agg agc aac ttt acc ctg act gct gct      576
 Ala Ser Leu His Thr Pro Leu Arg Ser Asn Phe Thr Leu Thr Ala Ala
             180                 185                 190

 cgg cac agt ctt tct ggt gtt ggg aat gtt ggc tgt gtt cca atc cag      624
 Arg His Ser Leu Ser Gly Val Gly Asn Val Gly Cys Val Pro Ile Gln
         195                 200                 205

 ttt cct atc aca gag gac cta gct gtc aca tac cat ctg acc tct gta      672
 Phe Pro Ile Thr Glu Asp Leu Ala Val Thr Tyr His Leu Thr Ser Val
     210                 215                 220

 tgg tgg ttt gtg act ctg ggg tga                                      696
 Trp Trp Phe Val Thr Leu Gly 
 225                 230





      <210> 391
      <211> 5145
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (4877)..(5131)

      <400> 391
 tttttttttt tttttttttt ttaggtttca tgtttgtttt atttaaagtc tggttgggta     60

 cagaaaacac acacacactt aacaggttaa aatatccaaa taaaatttac tgcaactttt    120

 gtagaatttt atttgtgcta caagacacgt tgcataggaa actatttaaa gcccctgagg    180

 aaaaaatatc catggtttaa ggtgcaactg gttttgtttc ttctttgggg aaaaggtgat    240

 agatggtctc tgggagaaat tatggggtgg agttgagaag cacaatcgaa ggttatatgg    300

 tgggatgatt ggcgaattgt gtgtcctggt tcttgcagca taaaatagct aatgtttgtt    360

 ctttttttca gtccgttggt cttcagtatc tgaataagta gctatacaac gtttcaggcc    420

 agtaagggag tatacattga ttatactaag gaagtaacat gtttcaagaa agcagtttta    480

 gagaatgaga ttcgggatcc caaatggtcc ctgacaactg caggcacaca ggaagtgtcc    540

 tggcacgttg ctaaggatca cctcactcta ctgatttgcc agtatcagtc cttcctcctg    600

 ctcccttcca acacgcgaca tctacgacgc attgtgagat tcacacagca tgtctgcacc    660

 ctaaagttat taatgcaaca ctgtgtcaag ttcctgattt tatgtgagtc acattttcat    720

 ttttacaaaa tgctcatctt gctcagatga tctttacatt gtacaaaaaa tggtttcatc    780

 taaactatga cttccttccg aggagacaca ggtacaccag gaaggaagag gggttaagcc    840

 ttagatgaaa tgaaatgcag agtttggcaa atggcagctg gcacctctgc acatcagcat    900

 aaggcgttgc ttgtgaggcc aaccacagca tctgcaataa gcacgagagt cagtggccac    960

 caaggctctg attcggtcat gaagttttct tcctgtccac agaagaggca gcaaactcta   1020

 tgggaagcac tgctttgacc tcaaggaaaa aacagtacaa tggcctcgta gcagcaggga   1080

 ccacctcact ctcaaatggc attgttcttg tcaatgacta attgcacact ggcaggggcc   1140

 ctaaagactg tcaactcatg gctgctttct aatctattgg cagaaacagc tcagggcacc   1200

 taaatgctaa tgcgggactt cactctgccc actgaagctc accaaagatt cacatattct   1260

 atggatggtc atttactacg agtgaggcaa agcacggaag acaatcaaat ccgaggaggg   1320

 agcaggacct ggggccttct cagaaagaat gagctgtacc cgtttactga aaagccactt   1380

 tttcccacgt gattcacctt cttacacgca gggagtgaaa gaggtccaac aaccgaacga   1440

 gcatctttcc gggctgagtg ttgaaatgca aagtgtggcc gggaatcaga aacgctccca   1500

 gtgaccttta aatacctata tacatctcta acataattta aaaaggtcta taacaacata   1560

 aaaacctcaa cagcctgtgc ccctattttc ttttaaacct ttatggtcca taaaaaaatt   1620

 agataccacc tttctcatag atcccttccc cccattcgtt aaaaaagtga ttttaaattt   1680

 aaatttatac ttaacaaata gaaagctatg tgattggcaa cgagctgcag taggcagtcc   1740

 cttcaggcct ctccctcgat ggaggagggc ggcgcatgat gggtgtagcc tagctggcgg   1800

 gccctaaatc tgtctgagca gccgcccctt cctccctctt cagctccgcg gtgacagcag   1860

 ggcacgcagg gcagaagagg gcttgcactc cagagcagca ggaggggagg ggacccattc   1920

 aaatcacgaa gtcgtcctgg tccgcagggc tgaaggcggc tgctctcaga acgtccaggg   1980

 agttcaccaa gatcagagtc ccagtgaggt gcttccagcg cttggtgatg gggtttttca   2040

 tcttgtccag gcccaggtgc agctcctgga tgacatcccg gtagctgtcc ccgatctgat   2100

 ggctccaggt gagtaagaag tcatacgcag gcttccacat ggcctcgctg tccacaaccc   2160

 cgttcctgtc ccggtgggga gactcgtagg cgtccatctg ctgcttggag accttggcca   2220

 gcttctcagc cagctcccgc cagcgctggg ccacctctac agccgtggtc aggagcacaa   2280

 agtcctggat gagtctgacc accaggccct ggcagtccat cttcagtagg gccatcacaa   2340

 gctccttctg gaaggacttc cgttctttgt tctcagtgtt gttacagtcc tccttcagct   2400

 tttctaggac ggacgccacc cgctcgggct cactatccag ctctgcccgg cagaaaaagg   2460

 tgagcggcag gttcacgtag cccagggcgt cagcgaagga gcgccagctg ctgatgttct   2520

 ccatgagcag ggtcctcacg gaggcataga tgtacgtgag gaatttgcag ggccgcagga   2580

 tctgctccag cagcaccgag gtgctcagct cggggcccga gcacaggctg ggccgggccc   2640

 tgccgaccac cagcacgttc ttggtgtgca cgaggcccac cctgccctgg tagtagccga   2700

 tgtaccactc cttggtccac agctggcccc ggagcctgac ccgctcctcg ctgagcaggg   2760

 cgatcccgtc gcccttcttg tactccagca ggtagtggtt cttgttctgc cgcaccacag   2820

 tcttgagcaa cttaccaaac ttgaggctgg acaccgggcg gtcctggaaa gtcgggtact   2880

 ttgtagtggt ggcaaacggg gacaggatga ttttcccgac ttcgttcttc ttgagaaacc   2940

 tcctttgccc ggaaggcttg atggcacttt tagggggtgg ctgaggagtc tggacacaaa   3000

 actgggtgag gatggcctcc tggtcgtcct tcacctgaac ccgcagcgtg aagtcagaga   3060

 gctcgttggg gttctgggag gtgatgggga agatcaggcg gctcaccttg cccagcttca   3120

 gctggaatcc tcgcaccact ttggcctgct cgctggcttt gacctcgtaa ttcgtcatat   3180

 tggaaaacat acagaccttg agatcctggg gcctggacaa aacgaactgg tgcttccccc   3240

 acagctgcag ggccaccggg gcagggttgg gtgcctggcg tgtgacctcg ctgaccagga   3300

 gcgtctttgg ggcacagtca tgcccaaaaa tggtcactac cgtcttgaag gatgggtgga   3360

 tgtgtttagg gccgtagaga cccactgtga cttttttatt gatgaagtcc cacacggtgg   3420

 aagggtagag gatgcttggg ccatgggcca cgacagccac gtacatacag ggctccaggt   3480

 tgtgcagctg tgcctggacc gtgtccccac agctgcagtt gagcgggacg gagacatatg   3540

 gcccttcctt cgagtcgctc ctcaggcact ggaggcccac tgtgcttttg ctaaaaaggt   3600

 cattttttat ctcggctgac actttcatct ccaagatgat agaggttttc acctccaggt   3660

 tgctcagctt gacctccagc acagggctga tgctgcagga cctgtcactg ttgagctcca   3720

 gcggggggtc cagcagggct ttcatggaga tctgctgggt ctccccaggg gcgacgtggc   3780

 cctcgggcac gtggatgctg atgctggtgt caggaagctg gacagcaccc ccggagctat   3840

 ccagcttgca cacgatgttt gtctccacgg cttgggtctg gccccaacca gggctttggc   3900

 caagcaagtc caggtcgtgg caagaccggg ccagcttcct gtggtttagc caggcagttc   3960

 gaaaatcctc ccggctctga aattgctcgg gggcaggtga tttcaagccg gtgaagaaac   4020

 tcgacgatgt gggagcatcg gacttggctt ggaggacgga gagttccgag agactgtagg   4080

 agcgcttgct tctgaagaag gggttgtccc gcctgaccgg cggctctgcg tggagtccgt   4140

 ttgtgactgg aagctcatcg aagatgttgc cagtgctatt cgtggtggct gagctggatt   4200

 cggtgaagga ggatgtacct gcgtcaaaaa ggagcaaatc cacagtactt ttgggattca   4260

 gctcatccag gctgggcatg acgggcacgt tcccattcag aaatggattg gtctggaccc   4320

 cattccagaa agggttatta ctgtacattc tgcctggtac ttttttgtca tctgtccatc   4380

 ccccgagcag ctccagctcc ttggctacct cgtctgggct gtctggaaga ttatcaatca   4440

 taccgctgtc actcagtgtt gagttccggt agttcaaggg ctgcacatag gaggagggga   4500

 tgtagcccat ttcggtggtg ttgtgtgcgt accaccactc accgccagat gtgtccaaga   4560

 cgtagagatg gtcgcccttg gagaacttca gtgtggtgaa gttggtgggg caatagtcct   4620

 tgatcgcaat cacttccttt gcatttccga aaggtgtggg gttgtctacg agcaaggcac   4680

 tgggagaagg cactttgatg tcattaaagc tcgtctctga aaacccttcg ctcaggtcaa   4740

 tcagggtccc ctctgacttg cagcgaggga ggccattgga gttggccgct cggatccgct   4800

 gagccgccat ctcgaaactc gcttcccggg taaagccgct aaggcttcat atttcttcct   4860

 ccagttatcc cagcag    atg ctg aag ctt ctg cct caa gca aac acg ctg    4909
                      Met Leu Lys Leu Leu Pro Gln Ala Asn Thr Leu
                        1               5                  10

 cgc ggc ggc atc cac tcg gca ata tgt ttc ttc ctg gta cag ccg cag     4957
 Arg Gly Gly Ile His Ser Ala Ile Cys Phe Phe Leu Val Gln Pro Gln
              15                  20                  25

 cct ctc gcc atc aga gaa gtc cca gga cac ggc ctt ctg tcc agg aga     5005
 Pro Leu Ala Ile Arg Glu Val Pro Gly His Gly Leu Leu Ser Arg Arg
          30                  35                  40

 gaa ggg aga cgc tgg ctc gca tgg cgt ccc cgc cgg ctc ctg agg ctc     5053
 Glu Gly Arg Arg Trp Leu Ala Trp Arg Pro Arg Arg Leu Leu Arg Leu
      45                  50                  55

 cgc tcg tcg gcc agc ggc tcg gcc cag ccg ggg gcg cgc gcg gct ccg     5101
 Arg Ser Ser Ala Ser Gly Ser Ala Gln Pro Gly Ala Arg Ala Ala Pro
  60                  65                  70                  75

 cgg gac tca cgg cgg cgg cgg cgg cgg tag tggcgagggg cccg             5145
 Arg Asp Ser Arg Arg Arg Arg Arg Arg 
                  80





      <210> 392
      <211> 742
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (252)..(455)

      <400> 392
 agatcttttt ttttattaaa gatatgcctt gtccttccta ggttctctat tgagatgaga     60

 aagcctcatt atgctgacat tttccacgcc acattaaata gttaaaaagg atgcagcctg    120

 gagccagaga gcagaaagct gggctggttc tgaagcttct tccatactta agttgcctcc    180

 aagcagtttg tgaaagtatc agatcttggt atcctggtga ttgattcacc taatataaat    240

 atatttgtgt c atg aac ctc tta tcc cgt tgc tgg agt tgt aat ctc cat     290
              Met Asn Leu Leu Ser Arg Cys Trp Ser Cys Asn Leu His
                1               5                  10

 cat cta gaa aac gtg gtc tgg tgc tat tct ttt cca agc agt acc ttg      338
 His Leu Glu Asn Val Val Trp Cys Tyr Ser Phe Pro Ser Ser Thr Leu
      15                  20                  25

 aag ttc cat ttt tgg ttc atg agt agc tat aga acg caa ggt gat aca      386
 Lys Phe His Phe Trp Phe Met Ser Ser Tyr Arg Thr Gln Gly Asp Thr
  30                  35                  40                  45

 tct ttg gtg ttt gcc aga gaa gtt ggc agc ccc acc cct cct acc agc      434
 Ser Leu Val Phe Ala Arg Glu Val Gly Ser Pro Thr Pro Pro Thr Ser
                  50                  55                  60

 ctt tgc act ctt caa att taa aa aggagctact tatcaacccc aggcccttct      487
 Leu Cys Thr Leu Gln Ile 
              65

 ggtcttagag gaaggactgg gccaacaaag agcaccatgg gagaatggca gtggtggcat    547

 ttagtgaaga caatttagta tgaatctctg caaaagattt ttttgatagc gttgagtgtc    607

 tgaaagtccc attatttttc ttttttcttt ttccccagta acactttcta gctccacgga    667

 taaggaatca ctgaacctag tagttcttag acagcttggt ttgagaatcc ttttgcggtt    727

 aaaaattagg gactg                                                     742




      <210> 393
      <211> 519
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (1)..(234)

      <400> 393
  atg tac gac tgt atg gaa acg ttt gcc ccg ggt ccg cga cgg ctg tac      48
  Met Tyr Asp Cys Met Glu Thr Phe Ala Pro Gly Pro Arg Arg Leu Tyr
    1               5                  10                  15

 ggg gcg gcc ggg ccc ggg gcc ggc ttg ctg cgc aga gcc acc ggc ggc       96
 Gly Ala Ala Gly Pro Gly Ala Gly Leu Leu Arg Arg Ala Thr Gly Gly
              20                  25                  30

 tcc tgt ttc gcc gga ctt gaa tct ttt gcc tgg ccg caa ccc gcc agc      144
 Ser Cys Phe Ala Gly Leu Glu Ser Phe Ala Trp Pro Gln Pro Ala Ser
          35                  40                  45

 ctg caa tgt agg tac cgg agt ccg ggg ctg ggg tgt agg gtg cag gag      192
 Leu Gln Cys Arg Tyr Arg Ser Pro Gly Leu Gly Cys Arg Val Gln Glu
      50                  55                  60

 agg gtg gga ttt act ctt tcc gtg tgt aaa gag tgg aac tga ggtgcaa      241
 Arg Val Gly Phe Thr Leu Ser Val Cys Lys Glu Trp Asn 
  65                  70                  75

 ggaggagctt ctggcccttt ctatgtaagg tactggccct ttaaacgtgg gggcctcagc    301

 gtctcctttg cgtgtgtgca gtagtgtttg gagtgtgtgt ggtttttatg gtgggtgttt    361

 agctcgaacc tgtggttgat gccactccag agttcctggg gatagggaga gaccgaggtg    421

 tgtgggtagt ttgcgccttc acgtccgtgg ccctggaagg atatgacact catgaccgtg    481

 ggtggcgttt gtaaagccca tgtgggaagc tggcagag                            519




      <210> 394
      <211> 1316
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (188)..(745)

      <400> 394
 agcccatgag tcgatgacat agccagagcg gtggaatttc tgagcccgcg gcggaccctc     60

 ccgcgccccc tctcgctctg cctctccctc tgcctctgcc tctgcctggc cgcggctctg    120

 ggaagtgcgc agtccgctct tgcccctgtt ctttgcttct cgttttgttg gagaagatat    180

 cacagtg  atg tct gca ttc aac ctg ctg cat ttg gtg aca aag agc cag     229
          Met Ser Ala Phe Asn Leu Leu His Leu Val Thr Lys Ser Gln
            1               5                  10

 cca gta gcc ctt cga gcc tgt ggg ctt ccc tca ggg tcg tgt agg gat      277
 Pro Val Ala Leu Arg Ala Cys Gly Leu Pro Ser Gly Ser Cys Arg Asp
  15                  20                  25                  30

 aaa aag aac tgt aag gtg gtc ttt tcc cag cag gaa ctg agg aag cgg      325
 Lys Lys Asn Cys Lys Val Val Phe Ser Gln Gln Glu Leu Arg Lys Arg
                  35                  40                  45

 cta aca ccc ctg cag tac cat gtc act cag gag aaa ggg acc gaa agt      373
 Leu Thr Pro Leu Gln Tyr His Val Thr Gln Glu Lys Gly Thr Glu Ser
              50                  55                  60

 gcc ttt gaa gga gaa tac aca cat cac aaa gat cct gga ata tat aaa      421
 Ala Phe Glu Gly Glu Tyr Thr His His Lys Asp Pro Gly Ile Tyr Lys
          65                  70                  75

 tgt gtt gtt tgt gga act cca ttg ttt aag tca gaa acc aaa ttt gac      469
 Cys Val Val Cys Gly Thr Pro Leu Phe Lys Ser Glu Thr Lys Phe Asp
      80                  85                  90

 tcc ggt tca ggt tgg cct tca ttc cac gat gtg atc aat tct gag gca      517
 Ser Gly Ser Gly Trp Pro Ser Phe His Asp Val Ile Asn Ser Glu Ala
  95                 100                 105                 110

 atc aca ttc aca gat gac ttt tcc tat ggg atg cac agg gtg gaa aca      565
 Ile Thr Phe Thr Asp Asp Phe Ser Tyr Gly Met His Arg Val Glu Thr
                 115                 120                 125

 agc tgc tct cag tgt ggt gct cac ctt ggg cac att ttt gat gat ggg      613
 Ser Cys Ser Gln Cys Gly Ala His Leu Gly His Ile Phe Asp Asp Gly
             130                 135                 140

 cct cgt cca act ggg aaa aga tac tgc ata aat tcg gct gcc ttg tct      661
 Pro Arg Pro Thr Gly Lys Arg Tyr Cys Ile Asn Ser Ala Ala Leu Ser
         145                 150                 155

 ttt aca cct gcg gat agc agt ggc acc gcc gag gga ggc agt ggg gtc      709
 Phe Thr Pro Ala Asp Ser Ser Gly Thr Ala Glu Gly Gly Ser Gly Val
     160                 165                 170

 gcc agc ccg gcc cag gca gac aaa gcg gag ctc tag agta atggagagtg      759
 Ala Ser Pro Ala Gln Ala Asp Lys Ala Glu Leu 
 175                 180                 185

 atggaaacaa agtgtactta atgcacagct tattaaaaaa atcaaaattg ttatcttaat    819

 agatatattt tttcaaaaac tataagggca gttttgtgct attgatattt tttcttcttt    879

 tgcttaaaca gaagccctgg ccatccatgt attttgcaat tgactagatc aagaactgtt    939

 tatagcttta gcaaatggag acagctttgt gaaacttctt cacaagccac ttataccctt    999

 tggcattctt ttctttgagc acatggcttc ttttgcagtt tttccccctt tgattcagaa   1059

 gcagagggtt catggtcttc aaacatgaaa atagagatct cctctgcagt gtagagacca   1119

 gagctgggca gtgcagggca tggagacctg caagacacat ggccttgagg cctttgcaca   1179

 gacccaccta agataaggat ggagtgatgt tttaatgaga ctgttcagct ttgtggaaag   1239

 tttgagctaa ggtcattttt tttttttctc actgaaaggg tgtgaaggtc taaaagcttt   1299

 ccttatgtta aattgtt                                                  1316




      <210> 395
      <211> 902
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (524)..(661)

      <400> 395
 tttttttata acaaacactt catttattac ttgtgtttat ttacactatt tacatattgc     60

 acaatagctg gaatactatt ttacatttat aatacaaacg accaacagaa ttagccacag    120

 atttacactc cactgtctct aaaacatgat cgaaatttta atttttcatg ccgttccaaa    180

 taatactctg agaatttaac agtgaaagta atacagaata tcaaattatg ttatatgaaa    240

 atatacttta agattctgct tatgtttcta aagaaatatt ttttgcgatt tcacctaatg    300

 aagacaatga aatattctgt gttttatagc actacacgtc aaatgtggag cattcctttt    360

 gtgttttttt tttaaataag tgacagataa cactgtcaag tacactgatt tatcgaatat    420

 atatctgcaa actgtcaaca acatacaaaa ctcaaaggac ttatggaaga gtctgtctgc    480

 aaaaataaat ctcttgtcca tgaggggatg tgtataaaga tag  ttc tgt ttc cct     535
                                                  Phe Cys Phe Pro
                                                    1

 gtt ggt ttc caa ggc act tct cat ggc tcc tgg tgt gct gct cct gta      583
 Val Gly Phe Gln Gly Thr Ser His Gly Ser Trp Cys Ala Ala Pro Val
   5                  10                  15                  20

 cgg tct gct cac tgc tta tcc tcc atg cac act gga ctg aca gcc agc      631
 Arg Ser Ala His Cys Leu Ser Ser Met His Thr Gly Leu Thr Ala Ser
                  25                  30                  35

 cgg gta aga agc ctg gcg cat ctt tta tag t atgcaggaat ggtgcagtct      682
 Arg Val Arg Ser Leu Ala His Leu Leu 
              40                  45

 ctggtgttgt gataaagtct atggaagtgt ttgctgcact ttggactaaa ataaagaggg    742

 cctgtaaggt gttttagaaa cttgtccttc atcctcagat ctcgaggaac aatttccact    802

 cgctgctccg gcgaaggccc cagccccgcc gcctccgcgc ggcccagggc gcagtcccgc    862

 ccgaggagct gcaggccctt gtgctccgcc gagtggtgct                          902




      <210> 396
      <211> 603
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (347)..(553)

      <400> 396
 caatgcctca cctcccaaca cttacccatc ggagactaat ttgtaacatg acctttggca     60

 tgcctaaatg ccatgagata tgctatgtgc tttttcttgt ctattgaacc atatacccta    120

 tcttgagtta acagacaatc atcatggaaa aggccaatct tggatgcggg agggaccctg    180

 ccttgtttgt gtatttatac ctgtatggga tagaccactc ttctctctct ggactccttg    240

 gctcacagca gcatatctcc atcattggca ttcaccatca ctatgaaggg cttcactgct    300

 tttgccatcc ttggtctagc agtcactgct tgggctacct cgccat   atg gga caa     355
                                                      Met Gly Gln
                                                        1

 aga gat caa gaa ttt caa ctc aga aaa ctt cat gaa ggt aaa tgt att      403
 Arg Asp Gln Glu Phe Gln Leu Arg Lys Leu His Glu Gly Lys Cys Ile
       5                  10                  15

 cag tgt acc agg tat tct gag gca tgt acc atg gac tac aca ctt cac      451
 Gln Cys Thr Arg Tyr Ser Glu Ala Cys Thr Met Asp Tyr Thr Leu His
  20                  25                  30                  35

 tgt gga tct gat gga aat gta tat tcc aac aga tgt acc ttt tgc aat      499
 Cys Gly Ser Asp Gly Asn Val Tyr Ser Asn Arg Cys Thr Phe Cys Asn
                  40                  45                  50

 acc gtt gtg aag agc caa ggt gca att tgg ttg aaa aat tat gga ttg      547
 Thr Val Val Lys Ser Gln Gly Ala Ile Trp Leu Lys Asn Tyr Gly Leu
              55                  60                  65

 tgc tga atctccctga tgcttaagga tatcaagtct cctttggcag attccactta       603
 Cys 






      <210> 397
      <211> 488
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (60)..(488)

      <400> 397
 gcgcggacgc gtgggcggga cccagcgaag aacctagcgg ccgaaaagag tcccaggaa      59                                                                 
 atg tgc ccc ccg gga tta ctg gta ttt gct ggc tcc tcg gaa caa gat      107
 Met Cys Pro Pro Gly Leu Leu Val Phe Ala Gly Ser Ser Glu Gln Asp
   1               5                  10                  15

 gcc aac ttg gct aag cag ttc tgg atc tcg gcg tcg atg tat ccc cct      155
 Ala Asn Leu Ala Lys Gln Phe Trp Ile Ser Ala Ser Met Tyr Pro Pro
              20                  25                  30

 agc gaa tct cag ctg gtg ctg cgc aga gac agc agt cag cgt ctg ccg      203
 Ser Glu Ser Gln Leu Val Leu Arg Arg Asp Ser Ser Gln Arg Leu Pro
          35                  40                  45

 gtg gcg cgg ccc agg agg agc aga ggg tct gaa aac agc cac tcc tcg      251
 Val Ala Arg Pro Arg Arg Ser Arg Gly Ser Glu Asn Ser His Ser Ser
      50                  55                  60

 cag tct ttt cac ctt gcg agt aac aaa aat aga gac atc ttt gcc gaa      299
 Gln Ser Phe His Leu Ala Ser Asn Lys Asn Arg Asp Ile Phe Ala Glu
  65                  70                  75                  80

 gcc cta aag ata cag gaa tct gag gag aaa gta aag tat ctc caa aag      347
 Ala Leu Lys Ile Gln Glu Ser Glu Glu Lys Val Lys Tyr Leu Gln Lys
                  85                  90                  95

 aag gaa gtc aca gta gat gag cag agc att gca tgt tct cca aag gaa      395
 Lys Glu Val Thr Val Asp Glu Gln Ser Ile Ala Cys Ser Pro Lys Glu
             100                 105                 110

 gtg att cca gaa aaa ttt gat aga cgt tca aaa aca tta tgc caa ggt      443
 Val Ile Pro Glu Lys Phe Asp Arg Arg Ser Lys Thr Leu Cys Gln Gly
         115                 120                 125

 tta aca gca tgt aag aga aac cct gcc atg ggc att gga atg tag          488
 Leu Thr Ala Cys Lys Arg Asn Pro Ala Met Gly Ile Gly Met 
     130                 135                 140





      <210> 398
      <211> 650
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (22)..(525)

      <400> 398
 ttctgcaagc tcagcagcag a  atg ccc aga gtc ttc cct ggt aga tgc agg      51
                          Met Pro Arg Val Phe Pro Gly Arg Cys Arg
                            1               5                  10

 ttc cat agc gac gtt ctc ctg caa tgc acg ctg gta ttc tgc aat agc       99
 Phe His Ser Asp Val Leu Leu Gln Cys Thr Leu Val Phe Cys Asn Ser
                  15                  20                  25

 agt cca tgt ttt tcc ttg agc ctg gat gct ttg gag cca agc ttt cgt      147
 Ser Pro Cys Phe Ser Leu Ser Leu Asp Ala Leu Glu Pro Ser Phe Arg
              30                  35                  40

 ccc atg caa ggg aaa caa cca ctt ctg gga cag agg act gct gtc tgc      195
 Pro Met Gln Gly Lys Gln Pro Leu Leu Gly Gln Arg Thr Ala Val Cys
          45                  50                  55

 cct ctc tgg tca ccc tgc cta gct aga gga tct gtg acc cca gcc atg      243
 Pro Leu Trp Ser Pro Cys Leu Ala Arg Gly Ser Val Thr Pro Ala Met
      60                  65                  70

 agg acc ctc gcc atc ctt gct gcc att ctc ctg gtg gcc ctg cag gcc      291
 Arg Thr Leu Ala Ile Leu Ala Ala Ile Leu Leu Val Ala Leu Gln Ala
  75                  80                  85                  90

 cag gct gag cca ctc cag gca aga gct gat gag gtt gct gca gcc ccg      339
 Gln Ala Glu Pro Leu Gln Ala Arg Ala Asp Glu Val Ala Ala Ala Pro
                  95                 100                 105

 gag cag att gca gcg gac atc cca gaa gtg gtt gtt tcc ctt gca tgg      387
 Glu Gln Ile Ala Ala Asp Ile Pro Glu Val Val Val Ser Leu Ala Trp
             110                 115                 120

 gac gaa agc ttg gct cca aag cat cca ggc tca agg aaa aac atg gcc      435
 Asp Glu Ser Leu Ala Pro Lys His Pro Gly Ser Arg Lys Asn Met Ala
         125                 130                 135

 tgc tat tgc aga ata cca gcg tgc att gca gga gaa cgt cgc tat gga      483
 Cys Tyr Cys Arg Ile Pro Ala Cys Ile Ala Gly Glu Arg Arg Tyr Gly
     140                 145                 150

 acc tgc atc tac cag gga aga ctc tgg gca ttc tgc tgc tga gcttgca      532
 Thr Cys Ile Tyr Gln Gly Arg Leu Trp Ala Phe Cys Cys 
 155                 160                 165

 gaaaaagaaa aatgagctca aaatttgctt tgagagctac agggaattgc tattactcat    592

 gtaccttctg ctcaatttcc tttcctcatc ccaaataaat gccttgttac aagaaaaa      650




      <210> 399
      <211> 392
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (119)..(358)

      <400> 399
 ctcaaatctt aagatctgtt tctactattc agttcctcaa actgaagctt attgaaaaaa     60

 aaatgtataa tgttatttgt tttattatag caattattcc taattaaagc agtattta      118                                                                 
 atg caa ttt cca gtt att tct ttg gag aat ttt atg tca ttg ttc cat      166
 Met Gln Phe Pro Val Ile Ser Leu Glu Asn Phe Met Ser Leu Phe His
   1               5                  10                  15

 tac ctt gaa tgt tgg aaa gat atg ata cgt gct gct tgt tca tca caa      214
 Tyr Leu Glu Cys Trp Lys Asp Met Ile Arg Ala Ala Cys Ser Ser Gln
              20                  25                  30

 aaa tca gta agc aca ata aag tgg atg cca aac cat cag aca cat aaa      262
 Lys Ser Val Ser Thr Ile Lys Trp Met Pro Asn His Gln Thr His Lys
          35                  40                  45

 tgt tcc cgc tgt gtc cct gga tat gga ata agc agg tat aaa aaa tat      310
 Cys Ser Arg Cys Val Pro Gly Tyr Gly Ile Ser Arg Tyr Lys Lys Tyr
      50                  55                  60

 ttt aat tat agt ttt gtt ata aat ata act tat gag aaa aaa att tga      358
 Phe Asn Tyr Ser Phe Val Ile Asn Ile Thr Tyr Glu Lys Lys Ile 
  65                  70                  75

 taggaataat actgtatatt actaattttt aact                                392




      <210> 400
      <211> 836
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (355)..(693)

      <400> 400
 gggtcgaccc acgcgtccga cggattacgg gcataagtca cctgatgctt tggctgaggt     60

 ttggaaggtg cctgattcat tgcgaaaggc tcttataaat tcatccattg ggctcaccta    120

 ccctttaggg aagtaatctt tcccaatgtg gtctcagaaa taaagcggat tgacagcatg    180

 ccatctcaac gatgaagaga agctccactg agcaatactg tgccccagga gatgtcataa    240

 ctgcacacct gtgtgcctac atcttgctgc ttcttatcac aaaacaaagg agtttgttca    300

 agaggtattt acaaatgccc agcattccca actgaagtgg cctttgcctt ggac  atg     357
                                                              Met
                                                                1

 tca aat gat gtc tcc ctg ttg gat ttt gag agg atg aga gac att tta      405
 Ser Asn Asp Val Ser Leu Leu Asp Phe Glu Arg Met Arg Asp Ile Leu
               5                  10                  15

 ttg tct ctg ttg atg aag atg gaa ata agt gac agt aac tgc cca aca      453
 Leu Ser Leu Leu Met Lys Met Glu Ile Ser Asp Ser Asn Cys Pro Thr
          20                  25                  30

 ggt gcc cgt gtg gcc att gtt tcc tac aat gcc aaa acc aat tac ttg      501
 Gly Ala Arg Val Ala Ile Val Ser Tyr Asn Ala Lys Thr Asn Tyr Leu
      35                  40                  45

 gtt cgt ttc tca gac tac aag ggg aag gtt gca ctc ctg gag gct gtc      549
 Val Arg Phe Ser Asp Tyr Lys Gly Lys Val Ala Leu Leu Glu Ala Val
  50                  55                  60                  65

 agg aac atc ccc ctg gag cag tca tct ggc cgc agg aac ctc ggg gcc      597
 Arg Asn Ile Pro Leu Glu Gln Ser Ser Gly Arg Arg Asn Leu Gly Ala
                  70                  75                  80

 acc atg agg ttt atg gcg aga cgt gtt caa acg tgt acg ctc ggg tct      645
 Thr Met Arg Phe Met Ala Arg Arg Val Gln Thr Cys Thr Leu Gly Ser
              85                  90                  95

 tct cat gag gaa ggt ggc tgt gtt ctt cca ggc ggg ctg ggc cta tga      693
 Ser His Glu Glu Gly Gly Cys Val Leu Pro Gly Gly Leu Gly Leu 
         100                 105                 110

 tgcagcttcc atcaatacag ccacactgga gcttgctgca gtgggcatca tccccgtggt    753

 catcaccttc acagaggggc acaacctccc ggacaccctg ctggtgggac aaaccagtac    813

 ccacccccag agctcactga agg                                            836




      <210> 401
      <211> 1722
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (47)..(808)

      <400> 401
 gccaccgtgg gcgagccgct tcccttctct gagcagcagt ttccag   atg gga gca      55
                                                      Met Gly Ala
                                                        1

 ggg aca gtg gcc ttg tac aga ctg ctg agg gcc cag cac cca cta cac      103
 Gly Thr Val Ala Leu Tyr Arg Leu Leu Arg Ala Gln His Pro Leu His
       5                  10                  15

 tgg cac ttt gtg ttt gca gga ccc atg cag act gcc cag gct cgg tct      151
 Trp His Phe Val Phe Ala Gly Pro Met Gln Thr Ala Gln Ala Arg Ser
  20                  25                  30                  35

 ggg gtt ctt gca gct ggc acc agc cct ccc ggc ccc ggc cgc cca ccc      199
 Gly Val Leu Ala Ala Gly Thr Ser Pro Pro Gly Pro Gly Arg Pro Pro
                  40                  45                  50

 gcc gcg ggg aag atg ccg gaa cag agt aac gat tac cgc gtg gtg gtg      247
 Ala Ala Gly Lys Met Pro Glu Gln Ser Asn Asp Tyr Arg Val Val Val
              55                  60                  65

 ttc ggg gcg ggc ggc gtg ggc aag agc tcg ctg gtg ctg cgc ttc gtg      295
 Phe Gly Ala Gly Gly Val Gly Lys Ser Ser Leu Val Leu Arg Phe Val
          70                  75                  80

 aag ggc acg ttc cgc gac acc tac atc ccc acc atc gag gac acc tac      343
 Lys Gly Thr Phe Arg Asp Thr Tyr Ile Pro Thr Ile Glu Asp Thr Tyr
      85                  90                  95

 cgg cag gtg atc agc tgc gac aag agc gtg tgc acg ctg cag atc aca      391
 Arg Gln Val Ile Ser Cys Asp Lys Ser Val Cys Thr Leu Gln Ile Thr
 100                 105                 110                 115

 gac acc acc ggc agc cac cag ttc ccg gcc atg cag cgc ctg tcc atc      439
 Asp Thr Thr Gly Ser His Gln Phe Pro Ala Met Gln Arg Leu Ser Ile
                 120                 125                 130

 tcc aag ggc cac gcc ttc atc ctg gtg ttc tcc gtc acc agc aag cag      487
 Ser Lys Gly His Ala Phe Ile Leu Val Phe Ser Val Thr Ser Lys Gln
             135                 140                 145

 tcg ctg gag gag ctg ggg ccc atc tac aag ctc atc gtg cag atc aag      535
 Ser Leu Glu Glu Leu Gly Pro Ile Tyr Lys Leu Ile Val Gln Ile Lys
         150                 155                 160

 ggc agc gtg gag gac atc ccc gtg atg ctc gtg ggc aac aag tgc gat      583
 Gly Ser Val Glu Asp Ile Pro Val Met Leu Val Gly Asn Lys Cys Asp
     165                 170                 175

 gag acg cag cgg gag gtg gac acg cgc gag gcg cag gcg gtg gcc cag      631
 Glu Thr Gln Arg Glu Val Asp Thr Arg Glu Ala Gln Ala Val Ala Gln
 180                 185                 190                 195

 gag tgg aag tgc gct ttc atg gag acc tcg gcc aag atg aac tac aac      679
 Glu Trp Lys Cys Ala Phe Met Glu Thr Ser Ala Lys Met Asn Tyr Asn
                 200                 205                 210

 gtc aag gag ctc ttc cag gag ctg ctg acg ctg gag acg cgc cgg aac      727
 Val Lys Glu Leu Phe Gln Glu Leu Leu Thr Leu Glu Thr Arg Arg Asn
             215                 220                 225

 atg agc ctc aac atc gac ggc aag cgc tcc ggg aag cag aag agg aca      775
 Met Ser Leu Asn Ile Asp Gly Lys Arg Ser Gly Lys Gln Lys Arg Thr
         230                 235                 240

 gac cgc gtc aag ggc aaa tgc acc ctc atg tga gcccggaa cgcccgccgg      826
 Asp Arg Val Lys Gly Lys Cys Thr Leu Met 
     245                 250

 cgcggcgggg agagaaaggt aggggagatg acgcgttgga cacggagaca cgaagaggag    886

 ccagaaggat acgagaggat gacaggtgac gaggtgagca gaaaaacaga acagaacgac    946

 acacagcgcc aacccaagag aaagaaaaac aggaccagaa gaccagcaca cgaaatcacg   1006

 cagagagaca aagaaggaca acaagaagca aaagcgacag cagaaccatc ccgagacaca   1066

 agaccaacca caaaacaccc ccaccaagcg atgcgcagga gacccagcca aacacaaaac   1126

 accaaagacg agcaaagaag cacctaaaga agagaaaaac gacaatcgaa aatagaaagc   1186

 gcgaggaagc aaacgacagg accacaaatg accaaacaaa aggcgaccag aaggacaaga   1246

 aaagagacag agaaaagccc accgcccaca caaagaacga caccaccggg aagagacatc   1306

 aagccagagg acagcaacac ccaacagaag agcgaacaca agaaccagag gaagacaaaa   1366

 ggggcgcacg agcccaagag caaagaaaga gcaggagaag gcaagacgaa cagaagaaaa   1426

 ggaccagaag cgaggaacga aagcacgaga cagaaacaca cgaaacagac ccgcagagaa   1486

 agaaaaagaa acagaagcga gcaaaaccag acgagcaaca aaaccccaac gacacgcgcg   1546

 aacaaccaag agagggaagg aagcacgaca gagcagagac cgcccagaca gagaacagaa   1606

 aaagacgcga acgaaaaagg caaacagcca cagcaaaaca gacaagcaaa gaaacacagg   1666

 gcaacgcgac ccaacacagc agcaccgacg aacaagcaga caacaaaaac aaaaaa       1722




      <210> 402
      <211> 786
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (71)..(433)

      <400> 402
 tttcgtgcct tggtgtcagt agtcattgcc agtttcgggc gttctggaca attgggatgc     60

 tgcagagttc   atg gct ggg gct gct cgt tgg gtg gga caa gaa tcc tct     109
              Met Ala Gly Ala Ala Arg Trp Val Gly Gln Glu Ser Ser
                1               5                  10

 gca atg gtt tgt ttt ggc tgc cca gga ggt gcg tca agt cgc tgc cgc      157
 Ala Met Val Cys Phe Gly Cys Pro Gly Gly Ala Ser Ser Arg Cys Arg
      15                  20                  25

 tcc cct cgt ggg cgt cag gcc tca aga gtt ccc cgc cta gaa aat gga      205
 Ser Pro Arg Gly Arg Gln Ala Ser Arg Val Pro Arg Leu Glu Asn Gly
  30                  35                  40                  45

 gct cag cga gtc gtg cgt acc atg gtg cac ctg gtt ttg cag cct aag      253
 Ala Gln Arg Val Val Arg Thr Met Val His Leu Val Leu Gln Pro Lys
                  50                  55                  60

 cgg gtc act tta gtg cat cct cct cgc gga ttg gag cct gtt tgc acc      301
 Arg Val Thr Leu Val His Pro Pro Arg Gly Leu Glu Pro Val Cys Thr
              65                  70                  75

 cct ata gcc cga atg aga ccc aag tca cac ggg ctc ata agt tct ttg      349
 Pro Ile Ala Arg Met Arg Pro Lys Ser His Gly Leu Ile Ser Ser Leu
          80                  85                  90

 ccc ctg gcc atg atc ccc cag cca gcc acc cga gtt tcc agg cct cag      397
 Pro Leu Ala Met Ile Pro Gln Pro Ala Thr Arg Val Ser Arg Pro Gln
      95                 100                 105

 gcg ctt tgg aaa cgc ctg tac aga cac tgt acc tga atgg caccaactca      447
 Ala Leu Trp Lys Arg Leu Tyr Arg His Cys Thr 
 110                 115                 120

 tctgctttag ctacatcata gtctgcacca cttctgccag ctcgatagca gcctggatct    507

 gagtcctaaa cttttcatgg tggatgaggg ttgtaaatat ccaaagcgac tccagatgaa    567

 attgccctca tcaaaggaag ctcagaagac agatttctgc atagaagcca aaaaagcctt    627

 ccctcaagga aagagtcagt ttcaagtatt tgcgaactca gaacagagtc aattttagat    687

 cactacaatg ctgcccatca aggaagaacc ctattgttcc ctggcgtctc tccttgagcc    747

 ctatacacag gagattcaga aactaagtca gcaaatggg                           786




      <210> 403
      <211> 1476
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (18)..(1166)

      <220>
      <221> misc_feature
      <222> (1)...(1476)
      <223> n = a,t,c or g

      <400> 403
 ccctgtaccg agaggtg   atg ctg gag acc tgt ggg ctt ctg gtt tca cta      50
                      Met Leu Glu Thr Cys Gly Leu Leu Val Ser Leu
                        1               5                  10

 ggg cat cgg gtt ccc aaa cca gag ttg gtc cac ctg cta gag cat ggg       98
 Gly His Arg Val Pro Lys Pro Glu Leu Val His Leu Leu Glu His Gly
              15                  20                  25

 cag gag ctg tgg ata gtg aag aga ggc ctc tca cat gct acc tgt gca      146
 Gln Glu Leu Trp Ile Val Lys Arg Gly Leu Ser His Ala Thr Cys Ala
          30                  35                  40

 ggt gac aga gca caa gtt cat acc aga gag cca acc act tac ccg cca      194
 Gly Asp Arg Ala Gln Val His Thr Arg Glu Pro Thr Thr Tyr Pro Pro
      45                  50                  55

 gtc tta tct gag cgg gcc ttt ctc cgg gga agc ctg act ctg gaa tct      242
 Val Leu Ser Glu Arg Ala Phe Leu Arg Gly Ser Leu Thr Leu Glu Ser
  60                  65                  70                  75

 tca acc tca agt gat tcg agg ttg ggg aga gct agg gat gag gaa ggg      290
 Ser Thr Ser Ser Asp Ser Arg Leu Gly Arg Ala Arg Asp Glu Glu Gly
                  80                  85                  90

 ctt ttg gaa atg cag aaa ggt aaa gtg aca ccg gag aca gac ctc cac      338
 Leu Leu Glu Met Gln Lys Gly Lys Val Thr Pro Glu Thr Asp Leu His
              95                 100                 105

 aag gag acc cat ctt ggg aaa gtg agc ctt gaa ggt gaa ggt ttg ggg      386
 Lys Glu Thr His Leu Gly Lys Val Ser Leu Glu Gly Glu Gly Leu Gly
         110                 115                 120

 aca gat gat ggt ctg cac tcc agg gca tta caa gag tgg tta tca gca      434
 Thr Asp Asp Gly Leu His Ser Arg Ala Leu Gln Glu Trp Leu Ser Ala
     125                 130                 135

 gat gtt ctc cat gaa tgt gac tca cag caa cca ggg aaa gac gcc ttg      482
 Asp Val Leu His Glu Cys Asp Ser Gln Gln Pro Gly Lys Asp Ala Leu
 140                 145                 150                 155

 att cat gca ggg aca aac ccc tac aaa tgc aag cag tgt ggg aaa ggt      530
 Ile His Ala Gly Thr Asn Pro Tyr Lys Cys Lys Gln Cys Gly Lys Gly
                 160                 165                 170

 ttt aac agg aag tgg tat ctc gtt cga cat cag agg gtt cac act gga      578
 Phe Asn Arg Lys Trp Tyr Leu Val Arg His Gln Arg Val His Thr Gly
             175                 180                 185

 atg aaa ccc tat gaa tgc aat gca tgt ggg aaa gcc ttt agc cag agc      626
 Met Lys Pro Tyr Glu Cys Asn Ala Cys Gly Lys Ala Phe Ser Gln Ser
         190                 195                 200

 tca act ctc att cgg cac tac ctc atc cac acc ggg gag aaa cca tac      674
 Ser Thr Leu Ile Arg His Tyr Leu Ile His Thr Gly Glu Lys Pro Tyr
     205                 210                 215

 aag tgc ctt gag tgt ggg aag gcc ttc aaa cgc agg tcg tac ctc atg      722
 Lys Cys Leu Glu Cys Gly Lys Ala Phe Lys Arg Arg Ser Tyr Leu Met
 220                 225                 230                 235

 cag cac cat cca atc cac act gga gag aaa ccc tat gag tgt agt caa      770
 Gln His His Pro Ile His Thr Gly Glu Lys Pro Tyr Glu Cys Ser Gln
                 240                 245                 250

 tgt cga aag gcc ttc acc cac cgg tct act ttt att cgc cat aat agg      818
 Cys Arg Lys Ala Phe Thr His Arg Ser Thr Phe Ile Arg His Asn Arg
             255                 260                 265

 acc cac act gga gaa aag ccc ttt gag tgc aaa gaa tgt gag aaa gcc      866
 Thr His Thr Gly Glu Lys Pro Phe Glu Cys Lys Glu Cys Glu Lys Ala
         270                 275                 280

 ttt agc aat aga gcc cac cta att caa cat tac atc atc cac act gga      914
 Phe Ser Asn Arg Ala His Leu Ile Gln His Tyr Ile Ile His Thr Gly
     285                 290                 295

 gag aag ccc tat gat tgc atg gca tgt gga aag gcc ttc aga tgc agc      962
 Glu Lys Pro Tyr Asp Cys Met Ala Cys Gly Lys Ala Phe Arg Cys Ser
 300                 305                 310                 315

 tca gaa ctc ata cag cac cag cgg att cac act ggg gag aag ccc tat     1010
 Ser Glu Leu Ile Gln His Gln Arg Ile His Thr Gly Glu Lys Pro Tyr
                 320                 325                 330

 gaa tgc acc cag tgt ggg aaa gcc ttt cac cgg agc acg tac ctc att     1058
 Glu Cys Thr Gln Cys Gly Lys Ala Phe His Arg Ser Thr Tyr Leu Ile
             335                 340                 345

 cag cac tct gtc atc cac act ggg gag atg ccc tac aag tgt atc gag     1106
 Gln His Ser Val Ile His Thr Gly Glu Met Pro Tyr Lys Cys Ile Glu
         350                 355                 360

 tgt ggg aag gcc ttc aaa cgc agg tca cac ctt ctg cag cac caa agg     1154
 Cys Gly Lys Ala Phe Lys Arg Arg Ser His Leu Leu Gln His Gln Arg
     365                 370                 375

 gtc cat aca tga gag aaccctattg ctgcaatgaa tacagcaagg cctttaccca     1209
 Val His Thr 
 380

 ctgttatttt atcattcata atgggaccca cactgtagga agaagtcctt cgaatgcaaa   1269

 gaatgtcagg aaacttttca ttttttttgt cagctctttc ttaactaaca catgagcagt   1329

 cactttggag agaagccctg tgaatacagt gaatgtaagg ttcccttcag tcaccactca   1389

 gttctcactc attgcagaag ggattcatac cagggggaaa tgtgggaagg catttccatc   1449

 ancatcaggg gaacttcatg ctggtgg                                       1476




      <210> 404
      <211> 474
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (10)..(474)

      <400> 404
 cccttcacc    atg ggc tgc tct ggc tgt ggg ggc tgt ggc tcc ggc tgt      48
              Met Gly Cys Ser Gly Cys Gly Gly Cys Gly Ser Gly Cys
                1               5                  10

 gga ggc tgt ggg ggc tgt ggc tcc ggc tgt gcg ggc tgt ggg gga tgt       96
 Gly Gly Cys Gly Gly Cys Gly Ser Gly Cys Ala Gly Cys Gly Gly Cys
      15                  20                  25

 ggc tcc ggc tgc tgt gtg cct gtc tgc tgc tgc aaa ccc atg tgc tgc      144
 Gly Ser Gly Cys Cys Val Pro Val Cys Cys Cys Lys Pro Met Cys Cys
  30                  35                  40                  45

 tgt gtg cca gct tgt tcc tgc tcc agc tgt ggc tgt ggc tcc tgt ggg      192
 Cys Val Pro Ala Cys Ser Cys Ser Ser Cys Gly Cys Gly Ser Cys Gly
                  50                  55                  60

 ggg tcc aag ggg ggc tgt ggt tct tat ggc tgc tcc cag tcc agc tgc      240
 Gly Ser Lys Gly Gly Cys Gly Ser Tyr Gly Cys Ser Gln Ser Ser Cys
              65                  70                  75

 tgc aag ccc tgc tgc tgc tcc tca ggc tgt ggg tca tcc tgc tgc cag      288
 Cys Lys Pro Cys Cys Cys Ser Ser Gly Cys Gly Ser Ser Cys Cys Gln
          80                  85                  90

 tcc agc tgc tgt aag cct tac tgc tgc cag tcc agc tgc tgt aag ccc      336
 Ser Ser Cys Cys Lys Pro Tyr Cys Cys Gln Ser Ser Cys Cys Lys Pro
      95                 100                 105

 tac tgc tgc cag tcc agc tgc tgt aag ccc tgt agc tgc ttc tca ggc      384
 Tyr Cys Cys Gln Ser Ser Cys Cys Lys Pro Cys Ser Cys Phe Ser Gly
 110                 115                 120                 125

 tgt gga tca tcc tgc tgc caa tcc agc tgc tac aag ccc tgc tgc tgc      432
 Cys Gly Ser Ser Cys Cys Gln Ser Ser Cys Tyr Lys Pro Cys Cys Cys
                 130                 135                 140

 cag tcc agc tgc tgt gtc ccc gtg tgc tgc cag tgt aag atc              474
 Gln Ser Ser Cys Cys Val Pro Val Cys Cys Gln Cys Lys Ile 
             145                 150                 155





      <210> 405
      <211> 941
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (358)..(891)

      <400> 405
 aaatccaccc agaacctcca ccctctgaca ccatggtcag ctcctgtcgt ggctctgtca     60

 gctctgagca gagctgtggc ctggagaact gctgccgccc cagctgctgc cagaccacct    120

 gctgcaggac cacctgctgc cgccccagct gctgcaagcc ccagtgctgc cagtctgtgt    180

 gctaccagcc cacctgctgc caccctagct gctgcatctc cagctgctgc cgcccctatt    240

 gctgtgaatc cagctgctgc cgcccctgct gcaagcctga tacctatgtg ccaacttgct    300

 ggctgctcaa caactgtcac ccgactcccg gactgagtgg gatcaacctg accacct       357                                                                 
 atg ttc agc ctg gct gtg aga gtc cct ggc tgt ggc cta gag aac tgc      405
 Met Phe Ser Leu Ala Val Arg Val Pro Gly Cys Gly Leu Glu Asn Cys
   1               5                  10                  15

 tgc cgt ccc agc tac tgc cag acc acc tgc tgc agg acc acc tgc tgc      453
 Cys Arg Pro Ser Tyr Cys Gln Thr Thr Cys Cys Arg Thr Thr Cys Cys
              20                  25                  30

 cgc ccc agc tgc tgt gtg tcc agc tgc tgc aga ccc cag tgc tgc cag      501
 Arg Pro Ser Cys Cys Val Ser Ser Cys Cys Arg Pro Gln Cys Cys Gln
          35                  40                  45

 acc acc tgc tgc agg acc acc tgc tgc cac ccc agc tgc tgt gtg tcc      549
 Thr Thr Cys Cys Arg Thr Thr Cys Cys His Pro Ser Cys Cys Val Ser
      50                  55                  60

 agc tgc tgc aga ccc cag tgc tgc cag tct gtg tgc tgc cag ccc acc      597
 Ser Cys Cys Arg Pro Gln Cys Cys Gln Ser Val Cys Cys Gln Pro Thr
  65                  70                  75                  80

 tgc tgc aga ccc caa tgc tgc cag act acc tgc tgt gag acc acc tgc      645
 Cys Cys Arg Pro Gln Cys Cys Gln Thr Thr Cys Cys Glu Thr Thr Cys
                  85                  90                  95

 tgc agg acc acc tgc tgc cgc ccc agc tgt tgt gta tcc agc tgc tgc      693
 Cys Arg Thr Thr Cys Cys Arg Pro Ser Cys Cys Val Ser Ser Cys Cys
             100                 105                 110

 agg ccc cag tgc tgc cag tct gtg tgc tgc caa ccc act tgt tcc cgc      741
 Arg Pro Gln Cys Cys Gln Ser Val Cys Cys Gln Pro Thr Cys Ser Arg
         115                 120                 125

 ccc agc tgc tgc atc tcc agc tgc tgc aag ccc cag ctg ctg tgt gtc      789
 Pro Ser Cys Cys Ile Ser Ser Cys Cys Lys Pro Gln Leu Leu Cys Val
     130                 135                 140

 tgt gtg ctg cag acc cca gtg ctg cca gtc tgt gtg ctg cca gcc cac      837
 Cys Val Leu Gln Thr Pro Val Leu Pro Val Cys Val Leu Pro Ala His
 145                 150                 155                 160

 ctg ctg cca ccc cag ctg cag cat ctc cag ctg ctg ccg ccc ctc ttg      885
 Leu Leu Pro Pro Gln Leu Gln His Leu Gln Leu Leu Pro Pro Leu Leu
                 165                 170                 175

 ctg tga atccagctgc tgccgcccct gctgctgcct gcgtccagtc tgtggcggag       941
 Leu 






      <210> 406
      <211> 1221
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (183)..(1070)

      <400> 406
 gcggcagcag ctggagatgc tgcagctggg gcggcagcag ttgggctggc agcacacaga     60

 ctggcagcac tggggcttgc agcagctgga cacacagcag ctggggcgac agcagctgga    120

 gatgcagcac ctagggtggc agcaggtcgt ctcacagcag ctggggcgac agcagttcaa    180

 ag   atg cca tgc agc ccc agt gct tcc agt ctg tgt gct gcc agc cca     227
      Met Pro Cys Ser Pro Ser Ala Ser Ser Leu Cys Ala Ala Ser Pro
        1               5                  10                  15

 ccc aac tgc tgt cac ccc agc tgt tgt cag acc acc tgc tgc aga acc      275
 Pro Asn Cys Cys His Pro Ser Cys Cys Gln Thr Thr Cys Cys Arg Thr
                  20                  25                  30

 acc tcc tgc tcc cac agc tgc tct gtg tcc agc tgc tgc aga ccc cag      323
 Thr Ser Cys Ser His Ser Cys Ser Val Ser Ser Cys Cys Arg Pro Gln
              35                  40                  45

 tgc tgc cat tcc gtg tgc tgc cag ccc acc tgc tgc cgc ccc agc tgc      371
 Cys Cys His Ser Val Cys Cys Gln Pro Thr Cys Cys Arg Pro Ser Cys
          50                  55                  60

 tgt cag acc acc tgc tgc agg acg acc tgc tgc cac ccc agc tgc tgt      419
 Cys Gln Thr Thr Cys Cys Arg Thr Thr Cys Cys His Pro Ser Cys Cys
      65                  70                  75

 gtg tcc agc tgc tgc aga ccc cag tgc tgc cat tcc gtg tgc ttc cag      467
 Val Ser Ser Cys Cys Arg Pro Gln Cys Cys His Ser Val Cys Phe Gln
  80                  85                  90                  95

 ccc acc tgc tgc cac ccc agc tgc tgc atc tcc agc agc tgc tgc ccc      515
 Pro Thr Cys Cys His Pro Ser Cys Cys Ile Ser Ser Ser Cys Cys Pro
                 100                 105                 110

 tct tgc tgc tgt ggc caa gac ctc tgc cag gag acc tgc tgc tgc ccc      563
 Ser Cys Cys Cys Gly Gln Asp Leu Cys Gln Glu Thr Cys Cys Cys Pro
             115                 120                 125

 agc tgc tgt cag acc acc tgc tgc agg acc acc tgc tac cgc ccc agc      611
 Ser Cys Cys Gln Thr Thr Cys Cys Arg Thr Thr Cys Tyr Arg Pro Ser
         130                 135                 140

 tac agt gtg tcc tgc tgc tgc aga ccc cag tgc tgc cag tct gtg tgc      659
 Tyr Ser Val Ser Cys Cys Cys Arg Pro Gln Cys Cys Gln Ser Val Cys
     145                 150                 155

 tgc cag ccc acc tgc tgc cgc ccc aga tgc tgc atc tcc agc tgc tgt      707
 Cys Gln Pro Thr Cys Cys Arg Pro Arg Cys Cys Ile Ser Ser Cys Cys
 160                 165                 170                 175

 cgc ccc agc tgc tgt gtg tcc agc tgc tgc aag ccc cag tgc tgc cag      755
 Arg Pro Ser Cys Cys Val Ser Ser Cys Cys Lys Pro Gln Cys Cys Gln
                 180                 185                 190

 tct gtg tgc tgc cag ccc acc tgc tgc cac cct agc tgc tgc atc tcc      803
 Ser Val Cys Cys Gln Pro Thr Cys Cys His Pro Ser Cys Cys Ile Ser
             195                 200                 205

 agc tgc tgc cgc ccc agc tgc tgt gtg tcc agc tgc tgc aag ccc cag      851
 Ser Cys Cys Arg Pro Ser Cys Cys Val Ser Ser Cys Cys Lys Pro Gln
         210                 215                 220

 tgc tgc cag tct gtg tgc tgc cag ccc acc tgc tgc cac cct agc tgc      899
 Cys Cys Gln Ser Val Cys Cys Gln Pro Thr Cys Cys His Pro Ser Cys
     225                 230                 235

 agc atc tcc agc tgc tgc cgc ccc tct tgc tgt gaa tcc agc tgc tgc      947
 Ser Ile Ser Ser Cys Cys Arg Pro Ser Cys Cys Glu Ser Ser Cys Cys
 240                 245                 250                 255

 cgc ccc tgc tgc tgc gtg cgt cca gtc tgt ggc cga gtc tcc tgc cac      995
 Arg Pro Cys Cys Cys Val Arg Pro Val Cys Gly Arg Val Ser Cys His
                 260                 265                 270

 acc act tgc tat cgc cca acc tgt gtc atc tcc acc tgt ccc cgc ccc     1043
 Thr Thr Cys Tyr Arg Pro Thr Cys Val Ile Ser Thr Cys Pro Arg Pro
             275                 280                 285

 gtg tgc tgc gcc tcc tct tgc tgc tga gccca ctgccctggc tcatctctcc     1095
 Val Cys Cys Ala Ser Ser Cys Cys 
         290                 295

 cttcgccgct ggtccacaaa tgtagaccat tcttctgtgc tgaatattag gacacatgga   1155

 gtgggattga tgtcattcag cagggtggac ctcatgtatc caatgagccc atcaccatcc   1215

 cgctga                                                              1221




      <210> 407
      <211> 541
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (10)..(531)

      <400> 407
 cccttcacc    atg ggc tgc tgt ggc tgc tcc gga ggc tgt ggc tcc ggc      48
              Met Gly Cys Cys Gly Cys Ser Gly Gly Cys Gly Ser Gly
                1               5                  10

 tgt ggg ggt tgt ggc tcc ggc tgt ggg ggc tgt ggc tcc ggc tgt ggg       96
 Cys Gly Gly Cys Gly Ser Gly Cys Gly Gly Cys Gly Ser Gly Cys Gly
      15                  20                  25

 ggc tat ggc tct ggc tgt ggg ggc tgt ggc tcc agc tgc tgt gtg ccc      144
 Gly Tyr Gly Ser Gly Cys Gly Gly Cys Gly Ser Ser Cys Cys Val Pro
  30                  35                  40                  45

 gtc tgc tgc tgc aag ccc gtg tgc tgc tgt gtg cca gcc tgt tcc tgc      192
 Val Cys Cys Cys Lys Pro Val Cys Cys Cys Val Pro Ala Cys Ser Cys
                  50                  55                  60

 acc agc tgt ggc tcc tgt ggg ggc tcc aag ggg gac tgt ggc tct tgt      240
 Thr Ser Cys Gly Ser Cys Gly Gly Ser Lys Gly Asp Cys Gly Ser Cys
              65                  70                  75

 ggg ggc tcc aaa ggg ggc tgt ggt tcc tgt ggg ggc tcc aag ggg ggc      288
 Gly Gly Ser Lys Gly Gly Cys Gly Ser Cys Gly Gly Ser Lys Gly Gly
          80                  85                  90

 tgt ggc tcc tgt ggg ggt tcc aag ggg ggc tgt ggt tct tgt ggc tgc      336
 Cys Gly Ser Cys Gly Gly Ser Lys Gly Gly Cys Gly Ser Cys Gly Cys
      95                 100                 105

 tcc cag tcc agc tgt tgt aag ccc tgt tgc tgc tcc tca ggc tgt gga      384
 Ser Gln Ser Ser Cys Cys Lys Pro Cys Cys Cys Ser Ser Gly Cys Gly
 110                 115                 120                 125

 tca tcc tgc tgc cag tcc agc tgc tgc aag ccc tgc tgc tgc cag tcc      432
 Ser Ser Cys Cys Gln Ser Ser Cys Cys Lys Pro Cys Cys Cys Gln Ser
                 130                 135                 140

 agc tgc tgt gtc ccc gtg tgc tgc cag tcc agc tgc tgc aag ccc tgt      480
 Ser Cys Cys Val Pro Val Cys Cys Gln Ser Ser Cys Cys Lys Pro Cys
             145                 150                 155

 tgc tgc cag tcc aac tgt tgt gtc cct gtg tgc tgc cag tgt aag atc      528
 Cys Cys Gln Ser Asn Cys Cys Val Pro Val Cys Cys Gln Cys Lys Ile
         160                 165                 170

 tga ggctctgacc                                                       541
 






      <210> 408
      <211> 1783
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (534)..(1232)

      <400> 408
 attggtgaca ttcagggatg tggctataga tttctctaag ggagagtggg aatgcctggg     60

 ccctgctcag agagacttgt acagagatgt catgttggag aactacagca actttgtgtc    120

 accggatatg ctgtctagat atgagaccaa ggagttaact cttaagaatg gcacttttga    180

 aaaggaatca ttaaaatgga aaataataga aagtgtcaga agttcttgcc ttgaggaatc    240

 ttttttggga aatgattgga aatgcaaagg actctttgag agacaacagg aaactacaga    300

 ggaatatttc aggcatgtaa ctgtgccatt tgaaaaaata tccgaattca tccagcctac    360

 atattttctt ctaaatcaaa taattcatac tggaaagaaa ctctatgaac aaaaaaaaaa    420

 atgaaaaaat gttactcaac agggaagaat tcatatcagt gacaagcttg acgaaatgtg    480

 tgggaacacc tctgtatttt gcacaaatca tatgaaacat cagacaaatt tta   atg     536
                                                              Met
                                                                1

 caa aga aat gca atg tat tta aag aat gtg gca gag act gct tgt aac      584
 Gln Arg Asn Ala Met Tyr Leu Lys Asn Val Ala Glu Thr Ala Cys Asn
               5                  10                  15

 ttt caa cta act caa tat caa ata agt cat gct aat cag aaa ccc tat      632
 Phe Gln Leu Thr Gln Tyr Gln Ile Ser His Ala Asn Gln Lys Pro Tyr
          20                  25                  30

 gaa tgt cag ata tgt gga aag ccc ttt aga aag cgt gcc cac ctt acc      680
 Glu Cys Gln Ile Cys Gly Lys Pro Phe Arg Lys Arg Ala His Leu Thr
      35                  40                  45

 caa cat aat cga att cac act ggt ggg aaa cca tat gaa tgc aaa gaa      728
 Gln His Asn Arg Ile His Thr Gly Gly Lys Pro Tyr Glu Cys Lys Glu
  50                  55                  60                  65

 tgt ggg aaa gtg ttt atc tgt tgt tca aca ttg att caa cat aag aga      776
 Cys Gly Lys Val Phe Ile Cys Cys Ser Thr Leu Ile Gln His Lys Arg
                  70                  75                  80

 act cac act agt gag aaa ccc tat gaa tgt ctg gaa tgt aga aag acg      824
 Thr His Thr Ser Glu Lys Pro Tyr Glu Cys Leu Glu Cys Arg Lys Thr
              85                  90                  95

 ttt agg cgg agt gca cat ctt att cga cat caa aga att cat act ggt      872
 Phe Arg Arg Ser Ala His Leu Ile Arg His Gln Arg Ile His Thr Gly
         100                 105                 110

 gag aaa cct tat aaa tgt aag caa tgt tgg aag gcc ttt gct tct gct      920
 Glu Lys Pro Tyr Lys Cys Lys Gln Cys Trp Lys Ala Phe Ala Ser Ala
     115                 120                 125

 tct gat tta act aga cat cgg aaa att cac act gat gag aga ctt tac      968
 Ser Asp Leu Thr Arg His Arg Lys Ile His Thr Asp Glu Arg Leu Tyr
 130                 135                 140                 145

 gaa tgt aca gaa tgt ggg aag gca ttt aac aat cgc tca act ctt att     1016
 Glu Cys Thr Glu Cys Gly Lys Ala Phe Asn Asn Arg Ser Thr Leu Ile
                 150                 155                 160

 cag cat cag aga att cac act ggt gag aag tcc ttt gaa tgt aag gaa     1064
 Gln His Gln Arg Ile His Thr Gly Glu Lys Ser Phe Glu Cys Lys Glu
             165                 170                 175

 tgt ggc aaa gca ttc aat aat tgc tca aca ctt act caa cac cag aga     1112
 Cys Gly Lys Ala Phe Asn Asn Cys Ser Thr Leu Thr Gln His Gln Arg
         180                 185                 190

 act cat act aat gag aaa tct tat gaa tgt cag gaa tgt aaa aag gct     1160
 Thr His Thr Asn Glu Lys Ser Tyr Glu Cys Gln Glu Cys Lys Lys Ala
     195                 200                 205

 ttt agg caa agt gca cat ctt act caa cat caa aga att cat act ggt     1208
 Phe Arg Gln Ser Ala His Leu Thr Gln His Gln Arg Ile His Thr Gly
 210                 215                 220                 225

 gag aaa cca tat gag tgt aag taa tgtgggaagg ctttcacttg tgtttctgat    1262
 Glu Lys Pro Tyr Glu Cys Lys 
                 230

 tttaatagac atcagagaat tcacactggt gaaaaaccct atgaatgtaa agaatgtggt   1322

 agagctttta acaattgttc agctcttatt caacaccaga gaattcacac tggtgagaag   1382

 gcttatgaat ataagcagtg tgggaaggtt tttgtctcct gtccaacact tgttcaacat   1442

 cagagaacac atactaatga aaaaccttat gaatgtcagt aatgcaagaa ggccttcaag   1502

 cataatgcac atctaatgag acatcagaga attcacagtg gggagaaacc ctatgaatgt   1562

 aatgaatgtg ggaatgcctt catttgtttt tttgatttta atagacatca gagaattcac   1622

 aaaggagaga aaccctatca gtgtaaagaa tgtgggaagg tttttaataa ttatccaact   1682

 cttactcaac atcaaagaat tcataccagt gtgaaaccct atgaatgtaa ggaatgtgta   1742

 aagaccttta cttggctttc aaacgctgtc gttgttctga g                       1783




      <210> 409
      <211> 926
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (95)..(256)

      <400> 409
 ctcagagaga aatgtttaga atagctccct acattaagca agcatctctg aatattcttt     60

 ctgtctctct tgtacatagg actgcaaggg aaga    atg cag aca atc aaa tgt     112
                                          Met Gln Thr Ile Lys Cys
                                            1               5

 gtg gtt gta gga gat gag gct ata ggt aaa acc tgc ctc ctc atc agt      160
 Val Val Val Gly Asp Glu Ala Ile Gly Lys Thr Cys Leu Leu Ile Ser
              10                  15                  20

 tat aca aca aat gtc ttt cct gag gag tat atc ccc cca ctg tct ttg      208
 Tyr Thr Thr Asn Val Phe Pro Glu Glu Tyr Ile Pro Pro Leu Ser Leu
          25                  30                  35

 aca att ata gcg tcc aga cat ccg tgg atg ggc aaa tcg tta gcc tga      256
 Thr Ile Ile Ala Ser Arg His Pro Trp Met Gly Lys Ser Leu Ala 
      40                  45                  50

 acacgtggga cactgctggc caagaggagt atgatgactg cgaacactct cctaacccca    316

 gaccagtatc tttgttattt gtttttccat tggcaactta gaatttccaa tttatgggac    376

 ttggttatct atgagtatgg ggaagtgaag atggaataaa ttatgactat gatttctagg    436

 atgtacaact agatagacaa tcagacaata agttgccagt tgggcaatga aaaatggaca    496

 tgtctggcag acaactagaa gcacaggtat ggagccctga agagaggtat ggggctggag    556

 atagtgatgt taacagatat attatggctg aagtaatgag aatgaaaagg caaggaaatg    616

 attcgagaaa gtatttctgg aaaagggaga agacagtatc aaggaggaaa aagtggtcaa    676

 tagtggcaaa tgcacaaaag ttcaagaatg gtatttctaa ccatatgcaa aaattttcag    736

 cataattagt caatagggaa atgcaaatca aaattacaat gaaataccac tttacaccca    796

 ctaggatggt tagaaggaaa aagatagaca ataacaagtg ttgataagga tatgaagaaa    856

 ctggaaccct tatacactgc tggtgggatt acaaaatggt gcagctgctc tggcaaacag    916

 tttggcagtt                                                           926




      <210> 410
      <211> 862
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (116)..(763)

      <400> 410
 ccgcgggtgg tcctgggctg ctcccacgcc acgaggtccc tgtccttccc aggagtcctg     60

 gcagccctgc accagcctca ccacacggat gtccgagggg taggcaggac ccagc atg     118
                                                              Met
                                                                1

 gcc gcg tcc acc atg tcc gtc tgc tcc agc gct tgc tcc gac tcc tgg      166
 Ala Ala Ser Thr Met Ser Val Cys Ser Ser Ala Cys Ser Asp Ser Trp
               5                  10                  15

 cag gtg gat gcc tgc cca gag agc tgc tgt gag ccc cac tgc tgc gcc      214
 Gln Val Asp Ala Cys Pro Glu Ser Cys Cys Glu Pro His Cys Cys Ala
          20                  25                  30

 ctc agc tgc tgc gcc ctg gcc ccc tgc ctg acc ctg gtc tgc acc cca      262
 Leu Ser Cys Cys Ala Leu Ala Pro Cys Leu Thr Leu Val Cys Thr Pro
      35                  40                  45

 gtg agc cgt gtg tcc agc ccc tgc tgc cag gca gcc tgt gag ccc agc      310
 Val Ser Arg Val Ser Ser Pro Cys Cys Gln Ala Ala Cys Glu Pro Ser
  50                  55                  60                  65

 ccc tgc caa tca ggc tgc acc agc tcc tgc acg ccc tcg tgc tgc cag      358
 Pro Cys Gln Ser Gly Cys Thr Ser Ser Cys Thr Pro Ser Cys Cys Gln
                  70                  75                  80

 cag tct agc tgc cag ccg gct tgc tgc acc tcc tcc ccc tgc cag cag      406
 Gln Ser Ser Cys Gln Pro Ala Cys Cys Thr Ser Ser Pro Cys Gln Gln
              85                  90                  95

 gcc tgc tgc atg ccc gtc tgc tgc aag cct gtg tgc tgc ctg ccc acc      454
 Ala Cys Cys Met Pro Val Cys Cys Lys Pro Val Cys Cys Leu Pro Thr
         100                 105                 110

 tgc tct aag gat tcc tct tca tgc tgc cag cag tct agc tgc cag cca      502
 Cys Ser Lys Asp Ser Ser Ser Cys Cys Gln Gln Ser Ser Cys Gln Pro
     115                 120                 125

 act tgc tgt gcc tct tcc tcc agc cag cag tcc tgc tgt gtg cct gtt      550
 Thr Cys Cys Ala Ser Ser Ser Ser Gln Gln Ser Cys Cys Val Pro Val
 130                 135                 140                 145

 tgc tgc aag cct gtg tgc tgc tct gag tca tcc tct tca tgc tgc cag      598
 Cys Cys Lys Pro Val Cys Cys Ser Glu Ser Ser Ser Ser Cys Cys Gln
                 150                 155                 160

 cag tct agc tgc cat cca gct tgc tgc acc tcc tcc ccc tgc cag cag      646
 Gln Ser Ser Cys His Pro Ala Cys Cys Thr Ser Ser Pro Cys Gln Gln
             165                 170                 175

 gcc tgc tgt gtg ccc gtc cgt tgc aag cct gtc tgt tgc aag ccc atc      694
 Ala Cys Cys Val Pro Val Arg Cys Lys Pro Val Cys Cys Lys Pro Ile
         180                 185                 190

 tcc tgt gtg ccc gtc tgc tct ggg gct tcc act tca tgc ctg gag agg      742
 Ser Cys Val Pro Val Cys Ser Gly Ala Ser Thr Ser Cys Leu Glu Arg
     195                 200                 205

 ggc tcc ttg gcg ctg gag tag at gaggtaggca ccagccgtgg tgctgaaggc      795
 Gly Ser Leu Ala Leu Glu 
 210                 215

 ctcccagtcc ctgcagccga cggtggggag gctgtgcacc gccacgaagc cctcgtagcc    855

 ctgccac                                                              862




      <210> 411
      <211> 1021
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (568)..(726)

      <400> 411
 gccttggggc ggtcccccag agtgcccccc gtgtgtgccg ggccgctggg cgcccccggt     60

 ggttcccgcc cgtcgcgtcc gccccccccg ccagcttggg ggtgcccccg cttactgttc    120

 gctaattggg ctataagttc cctaaattcc ccgagggcct gagccataac acagatctgg    180

 ctaccgccgt ccaggtctcc gtagatctta tcttgactgc atcttggccc catttgtagt    240

 tttacagctt cgattctcct ggttgttgtt tgaagagcag gcgcaaatcc tctagaggtt    300

 cacaggaata gctagcgttg tctcctggat tttcaggttc ctttggcagt atccaggatt    360

 tgactcaagt gtgatgtatc caagactcca ctccagccac tttaaccgca gttggggtag    420

 ataaaatgac tgggtagggt ccttcccagg atgtatcact ttggatgtcc gttcgtggtt    480

 gccaaaatgt taccgggggg tccttgctca cagagctccc aagatggtgg tgaaccactt    540

 ccaagatggt agcaggccgc ttccaag    atg gtg gca agc ctc gta ttc tct     591
                                  Met Val Ala Ser Leu Val Phe Ser
                                    1               5

 gac ctg gag ttc ttg gcc tca cgg att cca agg aat gga atc ttg ggc      639
 Asp Leu Glu Phe Leu Ala Ser Arg Ile Pro Arg Asn Gly Ile Leu Gly
      10                  15                  20

 cat gtg gta agt gtt ata gtt cta tta gaa gcc gtg ggt cac aga aga      687
 His Val Val Ser Val Ile Val Leu Leu Glu Ala Val Gly His Arg Arg
  25                  30                  35                  40

 gaa cca tgg aac cca gtg act agt gtt cag ctc aat tag aacaaaccca       736
 Glu Pro Trp Asn Pro Val Thr Ser Val Gln Leu Asn 
                  45                  50

 ggcacttagc cgtgcaggaa caatggcaag cctttagccc aattgggagc ggcaatgggc    796

 gcctcgctgg atcaggagca cagcggacac cctgcaggat ccagagggat gggagtcagc    856

 ggcaggtctg cggtggtggc aaacagcagt ggtggacggt gagcaaaagc tcagctcgag    916

 ccgtaagaaa catggaccag aagagtgcag ttgcaagatt taatagagtg aaatagcatg    976

 aaaacagctc ccatacaaag ggaagggacc caaggggggc tgctc                   1021




      <210> 412
      <211> 341
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (25)..(309)

      <400> 412
 attcggcacg aggtgagagt tgta   atg gcc cga ctg ttg agt gag ggg gag      51
                              Met Ala Arg Leu Leu Ser Glu Gly Glu
                                1               5

 cag ggg atc cca acg gct tgc gct gcc ttt gcg cac agc cgg cgg gcg       99
 Gln Gly Ile Pro Thr Ala Cys Ala Ala Phe Ala His Ser Arg Arg Ala
  10                  15                  20                  25

 cca cgt cgc ggc ctg gct ggg gta gga gag ggc ggt ccc cag tgc agt      147
 Pro Arg Arg Gly Leu Ala Gly Val Gly Glu Gly Gly Pro Gln Cys Ser
                  30                  35                  40

 tgg gtg aac tac cgt tgc aca ctg gag ttt ctg gtg tct ttg ctt gga      195
 Trp Val Asn Tyr Arg Cys Thr Leu Glu Phe Leu Val Ser Leu Leu Gly
              45                  50                  55

 act gac cta gct cgt ggc agg ggg aac tcg gct agc ggc ccc aca gcc      243
 Thr Asp Leu Ala Arg Gly Arg Gly Asn Ser Ala Ser Gly Pro Thr Ala
          60                  65                  70

 cct gct gac tca aaa caa ctg agt tgt aag acg ttg gac ggc gtg ccg      291
 Pro Ala Asp Ser Lys Gln Leu Ser Cys Lys Thr Leu Asp Gly Val Pro
      75                  80                  85

 cgc cga tgt tgt gct tga gaagagaatg gcctctggga gccccgccag gg          341
 Arg Arg Cys Cys Ala 
  90





      <210> 413
      <211> 1032
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (16)..(348)

      <400> 413
 cccaggaccc aggca atg gtc acg agt gtg acc ccc cca ggc ctt ccc ctg      51
                  Met Val Thr Ser Val Thr Pro Pro Gly Leu Pro Leu
                    1               5                  10

 gtt ccg ttt ccc tcc cta gcc cgg tcc cca cga tgg gtg ggg aca gtg       99
 Val Pro Phe Pro Ser Leu Ala Arg Ser Pro Arg Trp Val Gly Thr Val
          15                  20                  25

 ggc tgt gac aat gga tcg cga ctg ctg ttt tta cct ggc gga cga tgc      147
 Gly Cys Asp Asn Gly Ser Arg Leu Leu Phe Leu Pro Gly Gly Arg Cys
      30                  35                  40

 gcc cga att cgc ttt aac cag atg ccc ctc ttc gcc tgg agc cct ggg      195
 Ala Arg Ile Arg Phe Asn Gln Met Pro Leu Phe Ala Trp Ser Pro Gly
  45                  50                  55                  60

 agc agt ccc cct ctc cgc tca aca ata att agc ctt cga tct gat tac      243
 Ser Ser Pro Pro Leu Arg Ser Thr Ile Ile Ser Leu Arg Ser Asp Tyr
                  65                  70                  75

 cta cca gga atg gca agt ggc ctc gct gaa agt ctc ggc tct ttg aga      291
 Leu Pro Gly Met Ala Ser Gly Leu Ala Glu Ser Leu Gly Ser Leu Arg
              80                  85                  90

 aat gag aga tgg gag ccc tca ctg ccg atg ttt ctt cca cac gct ttg      339
 Asn Glu Arg Trp Glu Pro Ser Leu Pro Met Phe Leu Pro His Ala Leu
          95                 100                 105

 ctg ggt tag aggcaag ctcatgaccg ccttgaaaag ccattttaga caaatcttcc      395
 Leu Gly 
     110

 tttgcattct tgctggagcc cttctcttat gcccttcctt ggacatttgc tctttcactc    455

 cctcccccat gcactcaccc cacccatagt gactgcgctc ctcctgcctg cgacgctggc    515

 aacaggcagc acagtctaag gtccctcccg ggaaagtgtt cagagagggt tccattctgg    575

 gagaggcccc cactttcccc agaggtttca gattcgagtc aaccttgctg ctggcaaatg    635

 tcagcagaga atttcagagc ttgaagaatc cttagagagc atcagttcga gtctcttacc    695

 cggaaaaaac tggggggccc ggagaggcta agggtctgga gctcaagatg cccgccaggc    755

 agtggcaggg cagggtggtg cctggactgt gcaggacggc tctgtctctt cagcctctct    815

 gtcatccccg tcaggcccac tgtatttgga gatttcgacg ttgccttggg aacccctgcc    875

 cctccccaca gtgcccgccc agccccctcc catttcccct cctagcactt acttgcccct    935

 ggccctcctc ccagcctgtt tccccccatg cgggcaggaa ctgtattgca ctcactctaa    995

 taaatagatg attggaccaa ttaaaaaaaa aaaaaaa                            1032




      <210> 414
      <211> 471
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (1)..(471)

      <400> 414
  atg ggt tgg atc ctg ata tct gtg tca gtt agt gag agt tgg ttc tat      48
  Met Gly Trp Ile Leu Ile Ser Val Ser Val Ser Glu Ser Trp Phe Tyr
    1               5                  10                  15

 gac cct aga gct ctt tgt gtc ctt caa acg agg gtg ctg aaa caa gac       96
 Asp Pro Arg Ala Leu Cys Val Leu Gln Thr Arg Val Leu Lys Gln Asp
              20                  25                  30

 gaa cat aga act gtc tat acc aag caa aaa act cct gaa agc aca tgc      144
 Glu His Arg Thr Val Tyr Thr Lys Gln Lys Thr Pro Glu Ser Thr Cys
          35                  40                  45

 cca ctg cca gtg aga aaa caa ggt cat att gct aat aac cag atg ata      192
 Pro Leu Pro Val Arg Lys Gln Gly His Ile Ala Asn Asn Gln Met Ile
      50                  55                  60

 aca act cag tct gat tcc aga ttg agg cac tgc acc aaa ctg cct ctc      240
 Thr Thr Gln Ser Asp Ser Arg Leu Arg His Cys Thr Lys Leu Pro Leu
  65                  70                  75                  80

 aat aga aga gaa aaa gaa agc cca gaa ata tat cta gcc aaa ctc acc      288
 Asn Arg Arg Glu Lys Glu Ser Pro Glu Ile Tyr Leu Ala Lys Leu Thr
                  85                  90                  95

 tgc aga ggt cct gaa tgt gct tca aaa aca gga aag gtc tcc tcc ctc      336
 Cys Arg Gly Pro Glu Cys Ala Ser Lys Thr Gly Lys Val Ser Ser Leu
             100                 105                 110

 tgt ttt ttt ccc tgc ctg tcc gat cag cat gaa aaa gca aag ctt gtc      384
 Cys Phe Phe Pro Cys Leu Ser Asp Gln His Glu Lys Ala Lys Leu Val
         115                 120                 125

 ctc cta acc cca ctt cag cgg gat ctc acc aac gct gaa gga gca gtg      432
 Leu Leu Thr Pro Leu Gln Arg Asp Leu Thr Asn Ala Glu Gly Ala Val
     130                 135                 140

 gcc agg tgg tca ctc ctc ttg ctc ctc ctg gat gga taa                  471
 Ala Arg Trp Ser Leu Leu Leu Leu Leu Leu Asp Gly 
 145                 150                 155





      <210> 415
      <211> 5321
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (2616)..(2789)

      <400> 415
 ggcacttgga ccgataggta tttggagcat gagttaggaa ggatatgtct ttctccaggt     60

 gcgcagctga aagttgctga gaaaagctgc ctgtgttgct gtggtaacat gagaaggaat    120

 gaacagctct atacaaaaac tggccacaca ttataaggcc tattctatgc agttatgttt    180

 ttggctattt gctcatttag tcattgttta tcaaccaaac taggtaagcc aaggagttac    240

 aagacagctc tagagaagct ccctctgctt acaggacaat aatgcattgt ttgttgatac    300

 aaatgaatta tttgaatcca cagaagtgaa aaagggaaaa aatcctggct gacttgtggg    360

 aagagcgtac tgcagagcct agggcctgag ttaactcgct ggcggccctg caggcaggct    420

 tgatgggagc gcccagcaca tctgcccacc ctgcacaggg catgaagcac cgtgtgcaga    480

 gatctgtgag caaaagccca ggacgtgacc ttaggcaaga ggggtccttg gagaagtgga    540

 ggtgtgcatg gtgtgtagcc ttgcgtgtct gtgagcacgc cctagtggac ctgcgcctgg    600

 attatcgggc cagtctctcg gaggggtccg tgatgctgag ttacgccatt cacctgaact    660

 ctgcagctca tcggctgtag gatttgggtg agacactttt ccttgctgac tcatttcccc    720

 atctgcaaaa tgggggtgac gatatctacc tcttggggtg tgtcaagggt aaaagagcac    780

 actttaagaa tcctaaagca ctaagccaag gatgaaagac tagaaagctg cctctatgtt    840

 gctactctca aaaatgctca gaaattttct tgtcgtacta aaaatgtgtt atttttctca    900

 ttttcattct tccattcaac acagaagtaa tctaagtaag ttctaaaaac atagatccgg    960

 gggcccacag acattcaatt ttcttctgaa ttggctctgg tatcacacaa cacacaagca   1020

 agcaaacagc ctgcctgcta gggccttggg ttccaggctg gaggaatgca ggcagaaatc   1080

 tcttaggaaa taactaagtg agcgccaagt tttgaattgc cttagagccg aaagagaatg   1140

 tggcgtgctg gggagagatc tggacctctt tctcatcagt catttgacct gtccacgaag   1200

 aacaattttg ttatgcagcc tgggaacctg gtttccttac accctgcgcc cttaatgaca   1260

 cagacaacca cgggtactcc tggacggaag ctcatcacgc ctcctcaaat accttcaccc   1320

 atgttcaggt cacacggagg tcaccatctc ctcagcacac aacaactgct ttggttccca   1380

 gggttatttt ttctacgagt tgaaaaccca cggagcctaa gccatctttt tgtcccctaa   1440

 ggagagcccc atagactaag agctacactt cctgtctgtc tttcccacct ttccatctca   1500

 ttctagctta aagcttatca cgctactgag agcctgttct gtagttcaag gtggcagaga   1560

 aaaatacgaa ccttgagtga aatctggaga gcagtgcagg gtcatcccca gacgtgacgg   1620

 gccatatcct aggcgactcc tgcagcttat agaagcaggg aatttaatgg acttcttcca   1680

 ggaaagccag cccacgggga ctcttaaaaa gacaccaacc atttggaaga tgcagcttga   1740

 ggtctggggg actggactga ttctgccacc atatagtgaa cacgattaat cgggaggaag   1800

 aagtaaggca ctctgtgagt tagtctacca ccctattgac tttgacagag agaaaaccaa   1860

 cttttttcat atgatcacac agtagtactg gaatatctcg actgcaatat cctctaaaca   1920

 aatgcatgca aagctttgta aaagcagctg atgattaaaa aaattttaaa acattagggt   1980

 ttttctaata tatccatatg tgggacagtg atttaaatgt cattaattgt ccagccacaa   2040

 cttgtaacag tgatgtgaaa gacacaaaaa aggccccact ggagtggagg agtggtctgg   2100

 ctggtcccca agcaaaacag aatgggcttc gcataggctt tagaacttat tcataaatat   2160

 tgaccaaagt gtgaagcaag gtatccagtg aagattctct agggtctcta cttctgctca   2220

 agagatttaa tccagctttc tctaaagcag tggtccagac ttgccacata ctaggttaaa   2280

 gataaagtga gaaaaacaaa tactttggtt tgcacgtctc ttgaggggcc ctaggctgta   2340

 tggaggaata tttagaggaa tatttgtgag ctgccatttg tgtttaaaag aacatgaaag   2400

 caagacgggc cctaacccgc ctgtgtctgt agctgaccag gaggccactg cttccttccc   2460

 ccagagcttc taggagagcc ccccaaaatg caactctcca aggtcctgtg gagtagtccc   2520

 ctcataatgc ctccaccaca cctgtgtctc acgatgcctt aactgacgta gctcctaagt   2580

 gatgttcaca gagaaggaaa tacttaggca agccc   atg tgt aac atg ctc aca    2633
                                          Met Cys Asn Met Leu Thr
                                            1               5

 gat gtg ctg gct ttg cca atg ctt tcg gac tcc acc atg ctt tct gat     2681
 Asp Val Leu Ala Leu Pro Met Leu Ser Asp Ser Thr Met Leu Ser Asp
              10                  15                  20

 tct tct ggt cct agt cac gcc ttg gca cgg ggc aga agc ggc cga gct     2729
 Ser Ser Gly Pro Ser His Ala Leu Ala Arg Gly Arg Ser Gly Arg Ala
          25                  30                  35

 atg ctg aca ggt gct gct gag agc caa cag cca ttc agc cga gaa ggc     2777
 Met Leu Thr Gly Ala Ala Glu Ser Gln Gln Pro Phe Ser Arg Glu Gly
      40                  45                  50

 gtt tct agg tga ggg catgagagct ggcattccag gctgctgagt gcggcatctg     2832
 Val Ser Arg 
  55

 caggtgcacc acattgctcc acggtgtgtt cagaagagac cagcatcttg aatctcaggc   2892

 tctgggctca ttctttgcct ctgccaaggg accattcagg ggcttcaagc cagctgctga   2952

 aaatccccct tttctggatt tttccccatc tatataagga tatggtggct gtgtggacaa   3012

 gaaattggtt tcatctcaga agggtgcttc cctacaaaga tcttcagaaa tttaattgaa   3072

 aacaattttt tgaacttttt ttgtttggcc aggatgaatg aagctgaagt cacatcctga   3132

 atgtgcatgc cagacaaagg gtaagcaagc agtctttaca aatgccaatc cctctgcact   3192

 ccaaaaccgg agcccgtaat gaaggcccag gttccagtca tcacaggatc ccccaagcca   3252

 gcacagtgcc tgatgcctcc ctaggcatta gcacatccca gcactctaat tcacatcctc   3312

 agcatccctg cctcctgcat ccagggctta ggttgagtgt ttccagagtg tcaagtacat   3372

 ttaaacacaa accaaatact ccagggtttt gacctgtcac aatggctttt gaaaacaaca   3432

 gacgtacaat ttgagagaag gactcgatgg acttcttagg ctgaggacta aggacatgtt   3492

 gctgttcctc ttggtccagg acattcaata ccattcacag cattcatcac caactgacat   3552

 agtatcgatc acgacattca actgtttgaa attactgcta ttttggtcaa aaactaagaa   3612

 atcagaaatt gcacctacat agtgtgtctc ctcattggag tcccatctct ctgagcacag   3672

 ggatgggctc ctgagctcac agccctgccc tgccccccca gcagggcctc accctcatgg   3732

 ccctcagtga atagtgacta catgaagggg gcacttacta gaggcctgag taatggaatt   3792

 tcaattagct tctgcttccc ttttctaaaa aagaaccacc tttcttaaga ataattaggc   3852

 caaaataaac ttgagtaatt tgtacagtca atattttgaa gtttcggagt taccagtgaa   3912

 atagcaaagc tgttctccag gaaaggacat ccaggttccc acccaggcct tccttcctca   3972

 gctcctgcag cctcatccta gtttaatatg aaggttgtga atgggttaaa aagcagttct   4032

 taagcaccta cttagatctt ttcagtatct ggaaatagca cccagggctg tgttagtaaa   4092

 gcttttcact gggtaagagt catacaattt ttacatttaa tttgtttttt taaaacaagg   4152

 cagtcttgtt ttacatattg gaatgactag atattttttg acatttctgg cacctctggt   4212

 tctgctgaat tttaagggag gtgagtggta tgtacacaaa gttaagattg ctgcataata   4272

 attcctttgc atttccaaaa taaattacac aaatgtcact tttccttttc tattccatag   4332

 tactagtttt agccagatct ttgccaaaca ttctaggaca ttcagaaaag tcatccatgg   4392

 aattttggaa tgccattctc tctgtatctt tgcagatcat gaggaaggaa agttgatgaa   4452

 ctagtacggg atggctcaga cttgtaaagt gtctaagtca caacgctgca gagccagctt   4512

 ccgggtagca atggcatggc ctcagctgtg ccaaggctac aactggagct tccttactcg   4572

 catctgaggc aaacacagca aggctggccc aggccgccca cagtcaacag atgttcacgg   4632

 gagatggatc agcccctctt ttgcttgttc tatcaaggaa agagatctaa ccatgggcaa   4692

 gggtggaaca cacccggttc aggtcaggga atgagttgct ctaagtgaac agtgaattct   4752

 tacttctcag cctgtatcaa ttgtacccag ggttcatgat tactgtgacc cactaaggga   4812

 cgatctttga ggaaacagac ctggagggag gtaatttaag gagggaaagt gagtgggttt   4872

 tacagactgc tttgtggcga cattcaggaa cagaccattc aatggatgac ttttcagtac   4932

 ataaaagcaa gcagtaatgg ccaggagaga gcaaagatgc cctaagaatg acatcagact   4992

 gaccaaatgt gccttttcaa ataagttatg agaacgaatg aattggaatt agagcaaggt   5052

 attggacaga accatgctag tctttgagag aacgtgtgga ttgggtggat gtttggaccg   5112

 aatgaatggt aactttttaa tgtgaaacag agaactgata tatgggctgt catgtcaccc   5172

 tagggtactg tcgctctgtc atgtgtagca atctttccaa atttttgttg gtgggctgaa   5232

 caaagataaa actaataaag tatgtgtgga taccactaga aaaaaaaaaa aaaaaaaaaa   5292

 aaaaaaaaaa aaaaaaaaaa aaaaaaaaa                                     5321




      <210> 416
      <211> 698
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (14)..(604)

      <400> 416
 atggagagaa tcg   atg ggc ttc aga gcc tgt cac acg tgt tgt ccg tgt      49
                  Met Gly Phe Arg Ala Cys His Thr Cys Cys Pro Cys
                    1               5                  10

 aca cag atg ggc ttc ggg gcc tgt cat acg tgc tgt tcg tgt aca cag       97
 Thr Gln Met Gly Phe Gly Ala Cys His Thr Cys Cys Ser Cys Thr Gln
          15                  20                  25

 acg ggc tcc tgg gcc tat cac ccg tgc tgt ccg tgt aca cag atg ggc      145
 Thr Gly Ser Trp Ala Tyr His Pro Cys Cys Pro Cys Thr Gln Met Gly
      30                  35                  40

 ttc ggg gcc tgt cac acg tgt tgt ccg tac ggc ttc aga gcc tgt cac      193
 Phe Gly Ala Cys His Thr Cys Cys Pro Tyr Gly Phe Arg Ala Cys His
  45                  50                  55                  60

 acg tgc tgt tcg tgt aca cag acg ggc tcc tgg gcc tgt cac acg tgc      241
 Thr Cys Cys Ser Cys Thr Gln Thr Gly Ser Trp Ala Cys His Thr Cys
                  65                  70                  75

 tgt ccg tgt aca cag atg ggc ttc gga gcc tgt cac acc tgt ggt ccg      289
 Cys Pro Cys Thr Gln Met Gly Phe Gly Ala Cys His Thr Cys Gly Pro
              80                  85                  90

 tgt aca cag atg ggc ttc ggg gcc tgt cac acg tgt tgt ccg tgt aca      337
 Cys Thr Gln Met Gly Phe Gly Ala Cys His Thr Cys Cys Pro Cys Thr
          95                 100                 105

 cag atg ggc ttc ggg gcc tgt cac acg tgt tgt ccg tgt gca cag atg      385
 Gln Met Gly Phe Gly Ala Cys His Thr Cys Cys Pro Cys Ala Gln Met
     110                 115                 120

 ggc ttc ggg gcc tgt cac acg tgt tgt ccg tgt gca cag atg ggc ttc      433
 Gly Phe Gly Ala Cys His Thr Cys Cys Pro Cys Ala Gln Met Gly Phe
 125                 130                 135                 140

 gga gcc tgt cac acg tgt tgt ccg tgt gca cag atg ggc ttc gga gcc      481
 Gly Ala Cys His Thr Cys Cys Pro Cys Ala Gln Met Gly Phe Gly Ala
                 145                 150                 155

 tgt cac acg tgt tgt ccg tgt aca cag aca ggc tcc tgg gcc tat cat      529
 Cys His Thr Cys Cys Pro Cys Thr Gln Thr Gly Ser Trp Ala Tyr His
             160                 165                 170

 gtg tgc tgt ctt tgt aaa cag tca ggc tcc cag gac tat cac gcg tgc      577
 Val Cys Cys Leu Cys Lys Gln Ser Gly Ser Gln Asp Tyr His Ala Cys
         175                 180                 185

 tgt cca tgt aca caa gca ggc tcc tga tccca tctcacgtgc tgttcctgta      629
 Cys Pro Cys Thr Gln Ala Gly Ser 
     190                 195

 cacaaatgga gcttcaaagc tctgtccacc ttgttgggca tcgtcttacg aaatgctcct    689

 gagggctat                                                            698




      <210> 417
      <211> 643
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (170)..(502)

      <400> 417
 ggccatgggc cccattctcc acacagaagg caggggacag gtgcacaagg ggctgagacc     60

 ccagcagggc taactgtcct tgtctcagga gccctacctg gccagtcttg ggccaggcct    120

 tggggactgg gagtaggggc tgagccccgt ctgtacagtc tctggcccc    atg ggc     175
                                                          Met Gly
                                                            1

 acc agg tgc cag ctc ctc gca ccc agt act ccc att gct agg gct gct      223
 Thr Arg Cys Gln Leu Leu Ala Pro Ser Thr Pro Ile Ala Arg Ala Ala
           5                  10                  15

 gga acc tgc agg gtg gca gag ctg ggc agg act cac cct ata acc atg      271
 Gly Thr Cys Arg Val Ala Glu Leu Gly Arg Thr His Pro Ile Thr Met
      20                  25                  30

 tcc act gtg gtg ctg ctg ctg cag aga agt gtt tcc aat gct gcg acc      319
 Ser Thr Val Val Leu Leu Leu Gln Arg Ser Val Ser Asn Ala Ala Thr
  35                  40                  45                  50

 cgg gtg tgt agg acg ggg agg tca cga tgg cgc gac gtc tgc aga aat      367
 Arg Val Cys Arg Thr Gly Arg Ser Arg Trp Arg Asp Val Cys Arg Asn
                  55                  60                  65

 ttc atg agg agg tat cag tct aga gtt acc cag ggc ctc gtg gcc gga      415
 Phe Met Arg Arg Tyr Gln Ser Arg Val Thr Gln Gly Leu Val Ala Gly
              70                  75                  80

 gaa act gcc cag cag atc tgt gag gac ctc agg ttg tgt ata cct tct      463
 Glu Thr Ala Gln Gln Ile Cys Glu Asp Leu Arg Leu Cys Ile Pro Ser
          85                  90                  95

 aca ggt gag tgc aga ggt gac agc agg gat acc tcc tga gggttggaga       512
 Thr Gly Glu Cys Arg Gly Asp Ser Arg Asp Thr Ser 
     100                 105                 110

 cagcttcccc aggatatatc aaagctgcct ccttactccc ccatctccca gcttgggaaa    572

 gtgtggagaa ttgagcagat ggactttagc tagaaatgtt tgagaaatac tgattagagc    632

 ttgggcttca a                                                         643




      <210> 418
      <211> 1252
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (385)..(747)

      <400> 418
 tcacagcaca ttggtgagca ggtagctagt aggtagttgt ttgaagtatg catgcgtgca     60

 ttttagctgg gtgcagtttt ctgtatctac ttggtatttc tctcctcctc catggttaac    120

 cgaagaagag gaggactgac tggattccag cacttttttg cacagtatgg taggaagtgc    180

 cttcttggag tgaaggggtc ggagaaggca tccaacatct ttctcttctc tttggtcaat    240

 gtgtgaatgt gcttttccaa atccaccgtt aaaatctgaa cgtaggacgt cctgggactc    300

 cacacctgag aagtaaatga aagccttgct ttccagactc tcctgagtcc tcctcacttc    360

 acctgagtcc tctctactga cacc   atg ggt tgc tgt ggt tgt gga ggt tgt     411
                              Met Gly Cys Cys Gly Cys Gly Gly Cys
                                1               5

 ggt ggc tgc ggt ggc cgc tgt ggt ggc tgc ggt ggt ggc tgt ggt ggt      459
 Gly Gly Cys Gly Gly Arg Cys Gly Gly Cys Gly Gly Gly Cys Gly Gly
  10                  15                  20                  25

 ggc tgt ggt ggt ggc tgc ggt ggt ggc tgt ggt ggt ggc tgt ggt ggt      507
 Gly Cys Gly Gly Gly Cys Gly Gly Gly Cys Gly Gly Gly Cys Gly Gly
                  30                  35                  40

 ggc tgc ggt ggt ggc tgc ggt ggt ggc tgt ggt ggt agc tgt ggc agc      555
 Gly Cys Gly Gly Gly Cys Gly Gly Gly Cys Gly Gly Ser Cys Gly Ser
              45                  50                  55

 tgc acc acc tgc agg tgc tac cgg gtg ggc tgc tgc tcc agc tgc tgc      603
 Cys Thr Thr Cys Arg Cys Tyr Arg Val Gly Cys Cys Ser Ser Cys Cys
          60                  65                  70

 ccc tgc tgc cgc ggc tgc tgt gga ggc tgc tgc agc acg ccc gtg atc      651
 Pro Cys Cys Arg Gly Cys Cys Gly Gly Cys Cys Ser Thr Pro Val Ile
      75                  80                  85

 tgt tgc tgc cgc cgc acc tgc ggc tca tgt ggc tgc ggc tgt ggg aag      699
 Cys Cys Cys Arg Arg Thr Cys Gly Ser Cys Gly Cys Gly Cys Gly Lys
  90                  95                 100                 105

 ggc tgt tgc cag cag aaa ggc tgc tgc cag aag caa tgc tgc tgc tag      747
 Gly Cys Cys Gln Gln Lys Gly Cys Cys Gln Lys Gln Cys Cys Cys 
                 110                 115                 120

 gcgggtcccc ggcctctggg aagatgctgc aggtaacgaa ctgtcctgtt ggtaaatttt    807

 ctctccctcc tgccaggctt ctctgatttg aaagtcacaa gaagttttat ccacattccc    867

 tggtctctga gatcctgcct gcacgtgaaa accaccaaca caaaccttct ctatcaatca    927

 ccaatcaaag tatgagtcca aaaaaaaaca gagggatatt tttaatgcta tgttttcttg    987

 aaattttact gttgaaatgt ttgtttccat tccttttccc tcctttctgt agtttctgta   1047

 tcctgcatgt ctgctcctgc tttctgtttc tgtaaacctg agacaatatt ttcccaatta   1107

 accacataaa attggcatta aagattcatg gacatctcct tctttctttc attcttctaa   1167

 tgtgtctaaa ggaaagatgc gatgaaatct agaaaactaa cactccgtat gtttgtttgt   1227

 gatggcttta gaataataac taaca                                         1252






      <210> 419
      <211> 1127
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (118)..(1077)

      <400> 419
 cttaaactga agcaagttcg gtggacgccg gcggcgccct gatctaaaga aacgactcag     60

 ggactgcggc gcttgcacgt caacgggagg tgtgagccca aaggtctgga cccagaa       117                                                                 
 atg gga cgt cgg tca tca gat act gaa gaa gaa agc aga agc aag aga      165
 Met Gly Arg Arg Ser Ser Asp Thr Glu Glu Glu Ser Arg Ser Lys Arg
   1               5                  10                  15

 aaa aag aaa cac cgt aga cgg tcc tcc tcg agc agt tct tca gat agt      213
 Lys Lys Lys His Arg Arg Arg Ser Ser Ser Ser Ser Ser Ser Asp Ser
              20                  25                  30

 aga aca tac agc cga aag aaa gga gga agg aaa tca aga tca aag tca      261
 Arg Thr Tyr Ser Arg Lys Lys Gly Gly Arg Lys Ser Arg Ser Lys Ser
          35                  40                  45

 aga tct tgg tcc aga gat ctt cag cct cgt tca cat tct tat gat aga      309
 Arg Ser Trp Ser Arg Asp Leu Gln Pro Arg Ser His Ser Tyr Asp Arg
      50                  55                  60

 aga cgc agg cat cga tca agc agt agc tct tct tat ggc tcc aga agg      357
 Arg Arg Arg His Arg Ser Ser Ser Ser Ser Ser Tyr Gly Ser Arg Arg
  65                  70                  75                  80

 aaa cga agt cga agt cgt tca agg ggt cga ggg aaa tcc tat aga gtt      405
 Lys Arg Ser Arg Ser Arg Ser Arg Gly Arg Gly Lys Ser Tyr Arg Val
                  85                  90                  95

 cag agg tct agg tca aaa agc aga aca aga agg tcc agg tca aga cct      453
 Gln Arg Ser Arg Ser Lys Ser Arg Thr Arg Arg Ser Arg Ser Arg Pro
             100                 105                 110

 cgt ctc cgt tct cat agt cgt agc agt gaa agg tcc agt cac aga aga      501
 Arg Leu Arg Ser His Ser Arg Ser Ser Glu Arg Ser Ser His Arg Arg
         115                 120                 125

 acg cgt agt cgg tct cgg gat aga gaa cga cgt aag ggc aga gat aaa      549
 Thr Arg Ser Arg Ser Arg Asp Arg Glu Arg Arg Lys Gly Arg Asp Lys
     130                 135                 140

 gag aaa aga gaa aag gag aag gat aaa ggg aag gac aag gaa tta cat      597
 Glu Lys Arg Glu Lys Glu Lys Asp Lys Gly Lys Asp Lys Glu Leu His
 145                 150                 155                 160

 aac atc aaa cgt ggg gaa tct gga aac atc aaa gct gga tta gaa cat      645
 Asn Ile Lys Arg Gly Glu Ser Gly Asn Ile Lys Ala Gly Leu Glu His
                 165                 170                 175

 ctg cca cca gct gaa cag gcc aaa gcc aga cta cag ctg gtt ctt gaa      693
 Leu Pro Pro Ala Glu Gln Ala Lys Ala Arg Leu Gln Leu Val Leu Glu
             180                 185                 190

 gct gct gca aaa gct gat gaa gca ttg aaa gcc aaa gaa aga aat gag      741
 Ala Ala Ala Lys Ala Asp Glu Ala Leu Lys Ala Lys Glu Arg Asn Glu
         195                 200                 205

 gaa gaa gca aag aga aga aag gag gaa gac caa gcc acc ctg gta gaa      789
 Glu Glu Ala Lys Arg Arg Lys Glu Glu Asp Gln Ala Thr Leu Val Glu
     210                 215                 220

 caa gta aaa aga gta aaa gaa att gaa gct att gaa agt gat tct ttt      837
 Gln Val Lys Arg Val Lys Glu Ile Glu Ala Ile Glu Ser Asp Ser Phe
 225                 230                 235                 240

 gtt cag cag aca ttc aga tca agt aaa gaa gtc aaa aag tca gga gga      885
 Val Gln Gln Thr Phe Arg Ser Ser Lys Glu Val Lys Lys Ser Gly Gly
                 245                 250                 255

 agg agg aag gaa atc aag atc ttg act ttg atc ttg att tcc ttc ctc      933
 Arg Arg Lys Glu Ile Lys Ile Leu Thr Leu Ile Leu Ile Ser Phe Leu
             260                 265                 270

 ctt tct ttc ggc tgt atg ttc tac tat ctg agg aac tgc tcg agg agg      981
 Leu Ser Phe Gly Cys Met Phe Tyr Tyr Leu Arg Asn Cys Ser Arg Arg
         275                 280                 285

 acc gtc tac ggt gtt tct ttt ttc tct tgc ttc tgc ttt ctt ctt cag     1029
 Thr Val Tyr Gly Val Ser Phe Phe Ser Cys Phe Cys Phe Leu Leu Gln
     290                 295                 300

 tat ctg atg acc gac gtc cca ttt ctt tgg gct cac acc tcc cgt tga     1077
 Tyr Leu Met Thr Asp Val Pro Phe Leu Trp Ala His Thr Ser Arg 
 305                 310                 315

 cgtgcaagcg ccgcagtccc tgagtcgttt ctttagatca gggcgccgcc              1127




      <210> 420
      <211> 994
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (102)..(830)

      <400> 420
 agctgggtcc tgcaggacag agtcctctcc tcgtcccacc cctggggccc cagaaccctg     60

 gggctggagc tgcgtgggat cctccagaga acctgagagt g    atg gtt tcc caa     113
                                                  Met Val Ser Gln
                                                    1

 gca aac agg aca gtc ctg gaa aac ctc ggg aac ggc aca tcc ctc ccg      161
 Ala Asn Arg Thr Val Leu Glu Asn Leu Gly Asn Gly Thr Ser Leu Pro
   5                  10                  15                  20

 gtc ctg gag ggc caa agc ctg cgc ctg gtc tgt gtc acc cac agc agc      209
 Val Leu Glu Gly Gln Ser Leu Arg Leu Val Cys Val Thr His Ser Ser
                  25                  30                  35

 ccc cca gcc agg ctg agc tgg acc cgg tgg gga cag acc gtg ggc ccc      257
 Pro Pro Ala Arg Leu Ser Trp Thr Arg Trp Gly Gln Thr Val Gly Pro
              40                  45                  50

 tcc cag ccc tca gac ccc ggg gtc ctg gag ctg cca ccc att caa atg      305
 Ser Gln Pro Ser Asp Pro Gly Val Leu Glu Leu Pro Pro Ile Gln Met
          55                  60                  65

 gag cac gaa gga gag ttc acc tgc cac gct cag cac cct ctg ggc tcc      353
 Glu His Glu Gly Glu Phe Thr Cys His Ala Gln His Pro Leu Gly Ser
      70                  75                  80

 cag cac gtc tct ctc agc ctc tcc gtg cac tgg aag ctg gag cat ggg      401
 Gln His Val Ser Leu Ser Leu Ser Val His Trp Lys Leu Glu His Gly
  85                  90                  95                 100

 gga gga ctt ggc ctg ggg gct gcc ctg gga gct ggc gtc gct gcc ctg      449
 Gly Gly Leu Gly Leu Gly Ala Ala Leu Gly Ala Gly Val Ala Ala Leu
                 105                 110                 115

 ctc gct ttc tgt tcc tgc ctt gtc gtc ttc agg gtg aag atc tgc agg      497
 Leu Ala Phe Cys Ser Cys Leu Val Val Phe Arg Val Lys Ile Cys Arg
             120                 125                 130

 aag gaa gct cgc aag agg gca gca gct gag cag gac gtg ccc tcc acc      545
 Lys Glu Ala Arg Lys Arg Ala Ala Ala Glu Gln Asp Val Pro Ser Thr
         135                 140                 145

 ctg gga ccc atc tcc cag ggt cac cag cat gaa tgc tcg gca ggc agc      593
 Leu Gly Pro Ile Ser Gln Gly His Gln His Glu Cys Ser Ala Gly Ser
     150                 155                 160

 tcc caa gac cac ccg ccc cca ggt gca gcc acc tac acc ccg ggg aag      641
 Ser Gln Asp His Pro Pro Pro Gly Ala Ala Thr Tyr Thr Pro Gly Lys
 165                 170                 175                 180

 ggg gaa gag cag gag ctc cac tat gcc tcc ctc agc ttc cag ggc ctg      689
 Gly Glu Glu Gln Glu Leu His Tyr Ala Ser Leu Ser Phe Gln Gly Leu
                 185                 190                 195

 agg ctc tgg gag cct gcg gac cag gag gcc ccc agc acc acc gag tac      737
 Arg Leu Trp Glu Pro Ala Asp Gln Glu Ala Pro Ser Thr Thr Glu Tyr
             200                 205                 210

 tcg gag atc aag atc cac aca gga cag ccc ctg agg ggc cca ggc ttt      785
 Ser Glu Ile Lys Ile His Thr Gly Gln Pro Leu Arg Gly Pro Gly Phe
         215                 220                 225

 ggg ctt caa ttg gag agg gag atg tca ggg atg gtt cca aag tga aga      833
 Gly Leu Gln Leu Glu Arg Glu Met Ser Gly Met Val Pro Lys 
     230                 235                 240

 ggtctccatg gcaacaggac accagcaagt gtgtgggagt cgcactggtg tgacggccag    893

 aactggactc agatttcagc cccatcccca atgaagagct tgagtttgaa gattataccc    953

 aagtccaagt ggttcccatt tgaacattta aaaaaaaaaa a                        994




      <210> 421
      <211> 1095
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (428)..(1015)

      <400> 421
 gcaggtgcct gccctttgcg cctgcgccca gctcgccctg cctagccagg tgcgccccgc     60

 cccctgcctg cccggccacc ttcgggagcc gcttccaata ggcgttcgcc attggctctg    120

 gcgacctccg cgcgttggga ggtgtagcgc ggctctgaac gcgctgaggg ccgttgagtg    180

 tcgcaggcgg cgagggcgcg agtgaggagc agacccaggc atcgcgcgcc gagaaggccg    240

 ggcgtcccca cactgaaggt ccggaaaggc gacttccggg ggctttggca cctggcggac    300

 cctcccggag cgtcggcacc tgaacgcgag gcgctccatt gcgcgtgcgc gttgaggggc    360

 ttcccgcacc tgatcgcgag accccaacgg ctggtggcgt cgcctgcgcg tctcggctga    420

 gctggcc  atg gcg cag ctg tgc ggg ctg agg cgg agc cgg gcg ttt ctc     469
          Met Ala Gln Leu Cys Gly Leu Arg Arg Ser Arg Ala Phe Leu
            1               5                  10

 gcc ctg ctg gga tcg ctg ctc ctc tct ggg gtc ctg gcg gcc gac cga      517
 Ala Leu Leu Gly Ser Leu Leu Leu Ser Gly Val Leu Ala Ala Asp Arg
  15                  20                  25                  30

 gaa cgc agc atc cac gag aat gcc acg ggt gac ctg gcc acc agc agg      565
 Glu Arg Ser Ile His Glu Asn Ala Thr Gly Asp Leu Ala Thr Ser Arg
                  35                  40                  45

 aat gca gcg gat tcc tct gtc cca agt gct ccc aga agg cag gat tct      613
 Asn Ala Ala Asp Ser Ser Val Pro Ser Ala Pro Arg Arg Gln Asp Ser
              50                  55                  60

 gaa gac cac tcc agc gat atg ttc aac tat gaa gaa tac tgc acc gcc      661
 Glu Asp His Ser Ser Asp Met Phe Asn Tyr Glu Glu Tyr Cys Thr Ala
          65                  70                  75

 aac gca gtc act ggg cct tgc cgt gca tcc ttc cca cgc tgg tac ttt      709
 Asn Ala Val Thr Gly Pro Cys Arg Ala Ser Phe Pro Arg Trp Tyr Phe
      80                  85                  90

 gac gtg gag agg aac tcc tgc aat aac ttc atc tat gga ggc tgc cgg      757
 Asp Val Glu Arg Asn Ser Cys Asn Asn Phe Ile Tyr Gly Gly Cys Arg
  95                 100                 105                 110

 ggc aat aag aac agc tac cgc tct gag gag gcc tgc atg ctc cgc tgc      805
 Gly Asn Lys Asn Ser Tyr Arg Ser Glu Glu Ala Cys Met Leu Arg Cys
                 115                 120                 125

 ttc cgc cag cag gag aat cct ccc ctg ccc ctt ggc tca aag gtg gtg      853
 Phe Arg Gln Gln Glu Asn Pro Pro Leu Pro Leu Gly Ser Lys Val Val
             130                 135                 140

 gtt ctg gcg ggg ctg ttc gtg atg gtg ttg atc ctc ttc ctg gga gcc      901
 Val Leu Ala Gly Leu Phe Val Met Val Leu Ile Leu Phe Leu Gly Ala
         145                 150                 155

 tcc atg gtc tac ctg atc cgg gtg gca cgg agg aac cag gag cgt gcc      949
 Ser Met Val Tyr Leu Ile Arg Val Ala Arg Arg Asn Gln Glu Arg Ala
     160                 165                 170

 ctg cgc acc gtc tgg agc tcc gga gat gac aag gag cag ctg gtg aag      997
 Leu Arg Thr Val Trp Ser Ser Gly Asp Asp Lys Glu Gln Leu Val Lys
 175                 180                 185                 190

 aac aca tat gtc ctg tga ccgccc tgtcgccaag aggactgggg aagggagggg     1051
 Asn Thr Tyr Val Leu 
                 195

 agactatgtg tgagcttttt ttaaatagag ggattgactc ggat                    1095




      <210> 422
      <211> 2540
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (442)..(2286)

      <400> 422
 atttcgtgcc tgggggcagt aggacgggtc cgggaactaa tcccatctca aacacgtcgg     60

 agtggctttc tttgggggcc aaggcccgag cctgaggcgg gactccatga ggcctctggg    120

 gcgcgagcgg tttgactagg gggggcgatc ctttcggcgg ggctgacgca aggcgcggac    180

 aggagttctg acgatcggga accatcttgt ccggccttga tacgtctctg actacgcttc    240

 ccagaggtct cctcggcaag actgtacttc tcgcggtaat tcagcttcca actcacgcgc    300

 tggcgggacc ctcagggctt taccagcaac taccccagtg ccggggaggg ttctgctgct    360

 tcgaaagctg gtaaggcctg agctctaccc ttctccaaaa gaagagccaa gagaaggtcc    420

 ttttctacaa atatcagagc c  atg gct cag gag tca gtg atg ttc agt gat     471
                          Met Ala Gln Glu Ser Val Met Phe Ser Asp
                            1               5                  10

 gtg tcc gta gac ttc tct cag gag gag tgg gaa tgc ctg aat gat gat      519
 Val Ser Val Asp Phe Ser Gln Glu Glu Trp Glu Cys Leu Asn Asp Asp
                  15                  20                  25

 cag aga gat tta tac aga gat gtg atg ttg gag aat tac agc aac ctg      567
 Gln Arg Asp Leu Tyr Arg Asp Val Met Leu Glu Asn Tyr Ser Asn Leu
              30                  35                  40

 gtt tca atg ggg cat tct att tct aaa cca aat gtg atc tcc tac ttg      615
 Val Ser Met Gly His Ser Ile Ser Lys Pro Asn Val Ile Ser Tyr Leu
          45                  50                  55

 gag caa ggg aag gag ccc tgg ttg gct gac aga gag cta aca aga ggc      663
 Glu Gln Gly Lys Glu Pro Trp Leu Ala Asp Arg Glu Leu Thr Arg Gly
      60                  65                  70

 cag tgg cca gtc ctg gaa tca aga tgt gag acc aag aaa tta ttt ctg      711
 Gln Trp Pro Val Leu Glu Ser Arg Cys Glu Thr Lys Lys Leu Phe Leu
  75                  80                  85                  90

 aag aaa gaa att tat gaa ata gaa tca acc cag tgg gaa ata atg gaa      759
 Lys Lys Glu Ile Tyr Glu Ile Glu Ser Thr Gln Trp Glu Ile Met Glu
                  95                 100                 105

 aaa ctc aca aga cgt gat ttt cag tgc tcc agt ttc aga gat gat tgg      807
 Lys Leu Thr Arg Arg Asp Phe Gln Cys Ser Ser Phe Arg Asp Asp Trp
             110                 115                 120

 gaa tgt aat agg cag ttt aag aaa gaa ctc ggc tct cag ggg gga cat      855
 Glu Cys Asn Arg Gln Phe Lys Lys Glu Leu Gly Ser Gln Gly Gly His
         125                 130                 135

 ttc aat caa ttg gta ttc act cat gaa gat ctg ccc act ttg agt cac      903
 Phe Asn Gln Leu Val Phe Thr His Glu Asp Leu Pro Thr Leu Ser His
     140                 145                 150

 cat cca tcc ttc aca tta cag caa atc att aac agt aaa aag aaa ttc      951
 His Pro Ser Phe Thr Leu Gln Gln Ile Ile Asn Ser Lys Lys Lys Phe
 155                 160                 165                 170

 tgt gca tct aaa gaa tat agg aaa acc ttt aga cat ggc tca cag ttt      999
 Cys Ala Ser Lys Glu Tyr Arg Lys Thr Phe Arg His Gly Ser Gln Phe
                 175                 180                 185

 gct aca cat gag ata att cat acc att gag aag cct tat gaa tgt aag     1047
 Ala Thr His Glu Ile Ile His Thr Ile Glu Lys Pro Tyr Glu Cys Lys
             190                 195                 200

 gaa tgt gga aag tcc ttt aga cat ccc tca aga ctc act cat cat cag     1095
 Glu Cys Gly Lys Ser Phe Arg His Pro Ser Arg Leu Thr His His Gln
         205                 210                 215

 aaa att cat act ggc aag aaa ccc ttt gaa tgt aag gaa tgt gga aaa     1143
 Lys Ile His Thr Gly Lys Lys Pro Phe Glu Cys Lys Glu Cys Gly Lys
     220                 225                 230

 acc ttt att tgt ggc tca gac ctt act cga cat cac aga att cac act     1191
 Thr Phe Ile Cys Gly Ser Asp Leu Thr Arg His His Arg Ile His Thr
 235                 240                 245                 250

 ggt gag aaa ccc tat gaa tgt aag gaa tgt ggg aaa gcc ttt agt agt     1239
 Gly Glu Lys Pro Tyr Glu Cys Lys Glu Cys Gly Lys Ala Phe Ser Ser
                 255                 260                 265

 ggt tca aac ttc act cga cat caa aga att cac aca ggt gaa aag cct     1287
 Gly Ser Asn Phe Thr Arg His Gln Arg Ile His Thr Gly Glu Lys Pro
             270                 275                 280

 tat gaa tgc aaa gaa tgc ggg aag gcc ttt agt agt ggc tca aac ttt     1335
 Tyr Glu Cys Lys Glu Cys Gly Lys Ala Phe Ser Ser Gly Ser Asn Phe
         285                 290                 295

 act caa cat cag aga att cat act ggg gaa aaa ccc tat gaa tgt aag     1383
 Thr Gln His Gln Arg Ile His Thr Gly Glu Lys Pro Tyr Glu Cys Lys
     300                 305                 310

 gaa tgt ggc aat gcc ttt agt cag agc tca caa ctt att aaa cat caa     1431
 Glu Cys Gly Asn Ala Phe Ser Gln Ser Ser Gln Leu Ile Lys His Gln
 315                 320                 325                 330

 aga atc cat aca ggt gag aaa cct tac gaa tgt aag gaa tgt gaa aag     1479
 Arg Ile His Thr Gly Glu Lys Pro Tyr Glu Cys Lys Glu Cys Glu Lys
                 335                 340                 345

 gct ttt cgt tct ggc tca gac ctt act aga cat cag aga att cat act     1527
 Ala Phe Arg Ser Gly Ser Asp Leu Thr Arg His Gln Arg Ile His Thr
             350                 355                 360

 ggg gag aaa ccc tat gaa tgt aag ata tgt ggg aag gct tat tct cag     1575
 Gly Glu Lys Pro Tyr Glu Cys Lys Ile Cys Gly Lys Ala Tyr Ser Gln
         365                 370                 375

 agt tca cag ctt att agt cat cat aga att cat act aga cct gga ccc     1623
 Ser Ser Gln Leu Ile Ser His His Arg Ile His Thr Arg Pro Gly Pro
     380                 385                 390

 ttc cta ggg atc att ggc atc ttt ggt att gga ggg agc ctg ttg gaa     1671
 Phe Leu Gly Ile Ile Gly Ile Phe Gly Ile Gly Gly Ser Leu Leu Glu
 395                 400                 405                 410

 tat cga gcc agc ctc ctt gct ggc cat ggc ttt gcc acg ttc gct cta     1719
 Tyr Arg Ala Ser Leu Leu Ala Gly His Gly Phe Ala Thr Phe Ala Leu
                 415                 420                 425

 gct tgt tat aac ttt gaa gat ctc ccc aag aac gtg gac aac ata ccc     1767
 Ala Cys Tyr Asn Phe Glu Asp Leu Pro Lys Asn Val Asp Asn Ile Pro
             430                 435                 440

 ctg gag tac ttc gaa gaa gcc cta tgc tac atg ctt caa cat ccc cag     1815
 Leu Glu Tyr Phe Glu Glu Ala Leu Cys Tyr Met Leu Gln His Pro Gln
         445                 450                 455

 gta aaa ggc cca ggc act ggg ctt tgg ggc att tct cta gga gct gat     1863
 Val Lys Gly Pro Gly Thr Gly Leu Trp Gly Ile Ser Leu Gly Ala Asp
     460                 465                 470

 att tgt ctc tca atg gcc tca ttc ttg aag aat gac tca gac aca gtt     1911
 Ile Cys Leu Ser Met Ala Ser Phe Leu Lys Asn Asp Ser Asp Thr Val
 475                 480                 485                 490

 tcc atc aat gga tcc ggg atc agt ggg aac aga ggc ata aac tgt aag     1959
 Ser Ile Asn Gly Ser Gly Ile Ser Gly Asn Arg Gly Ile Asn Cys Lys
                 495                 500                 505

 cag aat agc att cca cca ttg ggc tat gac ctg agg aga atc aag gta     2007
 Gln Asn Ser Ile Pro Pro Leu Gly Tyr Asp Leu Arg Arg Ile Lys Val
             510                 515                 520

 gct ttc tca ggc ctc gtg gac gtc gtg gat ata aag aat gat ctt gta     2055
 Ala Phe Ser Gly Leu Val Asp Val Val Asp Ile Lys Asn Asp Leu Val
         525                 530                 535

 gga ggg tat aag aac ccc agc atg att tca atg gag aag gcc cag ggc     2103
 Gly Gly Tyr Lys Asn Pro Ser Met Ile Ser Met Glu Lys Ala Gln Gly
     540                 545                 550

 ccc atc att ttc att gtt ggt cag gat gac cat aac tgg agg agt gag     2151
 Pro Ile Ile Phe Ile Val Gly Gln Asp Asp His Asn Trp Arg Ser Glu
 555                 560                 565                 570

 ttg tat gcc cag tct ctg aac ggt tac ggg ccc atg gaa agg aaa aac     2199
 Leu Tyr Ala Gln Ser Leu Asn Gly Tyr Gly Pro Met Glu Arg Lys Asn
                 575                 580                 585

 ccc aga tca tct gtt acc ctg gga ctg ggc ttt aca ctg agc ctc ctt     2247
 Pro Arg Ser Ser Val Thr Leu Gly Leu Gly Phe Thr Leu Ser Leu Leu
             590                 595                 600

 act tcc ccc tgt gcc cag ctt ccc ttc aca aat tac tga acaaacacgt      2296
 Thr Ser Pro Cys Ala Gln Leu Pro Phe Thr Asn Tyr 
         605                 610

 gatatgggtt ggggacccca gggctcattc taaggcccag gtagatgcct ggaagcaaat   2356

 tctagccgcc ttctgcaaac acctgggagg tacccagaaa acagctttcc ctaaattgta   2416

 atgcgtttgt ctgttgttga catgagagag tcaagatcag attctagtgt tcaataaccc   2476

 tatgtgaatc agctgtctcc tggataacat taaagccatg tctttgtcat taaaaaaaaa   2536

 aaaa                                                                2540




      <210> 423
      <211> 1486
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (40)..(1347)

      <400> 423
 gcgcagggcc cgctccaaac ataacgcgct gtggaaaac   atg ctg ctc ggg gga      54
                                              Met Leu Leu Gly Gly
                                                1               5

 ccc ccc cgc agt ccc cgc tcg ggg acg agc ccc aag ggg ccc tgg agc      102
 Pro Pro Arg Ser Pro Arg Ser Gly Thr Ser Pro Lys Gly Pro Trp Ser
                  10                  15                  20

 agt aca ggc cac gtg cag ttt ggc aag agc ccc cag acc tgg ccc agg      150
 Ser Thr Gly His Val Gln Phe Gly Lys Ser Pro Gln Thr Trp Pro Arg
              25                  30                  35

 cgc aca aga ccc cgc tct cca gag cct gcc gcg cct tca ggg gtt cgg      198
 Arg Thr Arg Pro Arg Ser Pro Glu Pro Ala Ala Pro Ser Gly Val Arg
          40                  45                  50

 ggc tcc act tgg acg agg cgc cgt gac tct ccg agg cgc gcc ggg ccg      246
 Gly Ser Thr Trp Thr Arg Arg Arg Asp Ser Pro Arg Arg Ala Gly Pro
      55                  60                  65

 aca gcg ctg tcc cgc tac gtg ggc cac ctc tgg atg ggc cgg cgg ccg      294
 Thr Ala Leu Ser Arg Tyr Val Gly His Leu Trp Met Gly Arg Arg Pro
  70                  75                  80                  85

 ccc tcc ccc gag gcc cgc ggc cca gtc ccc cgc agt tca gct gcc agt      342
 Pro Ser Pro Glu Ala Arg Gly Pro Val Pro Arg Ser Ser Ala Ala Ser
                  90                  95                 100

 cgg gcc aga aga agc ctc gcc tcc ccg ggg atc tcc cca ggc ccc ctg      390
 Arg Ala Arg Arg Ser Leu Ala Ser Pro Gly Ile Ser Pro Gly Pro Leu
             105                 110                 115

 acc gca acg atc gga ggg gcg gtg gcg ggg ggc ggg ccc agg cag ggg      438
 Thr Ala Thr Ile Gly Gly Ala Val Ala Gly Gly Gly Pro Arg Gln Gly
         120                 125                 130

 agg gca gaa gca cac aag gaa gtg ttt ccg gga cag agg gtg ggc aag      486
 Arg Ala Glu Ala His Lys Glu Val Phe Pro Gly Gln Arg Val Gly Lys
     135                 140                 145

 atg gcg gcg ccc atg gag ctg ttc tgc tgg tca ggg ggc tgg ggg ctg      534
 Met Ala Ala Pro Met Glu Leu Phe Cys Trp Ser Gly Gly Trp Gly Leu
 150                 155                 160                 165

 ccg tca gtg gac ctg gac agc ctg gcc gtg ctg acc tat gcc aga ttt      582
 Pro Ser Val Asp Leu Asp Ser Leu Ala Val Leu Thr Tyr Ala Arg Phe
                 170                 175                 180

 act ggt gct cca ctg aag gta cac aag atc agc aac ccc tgg cag agc      630
 Thr Gly Ala Pro Leu Lys Val His Lys Ile Ser Asn Pro Trp Gln Ser
             185                 190                 195

 cct tca gga act ctg cct gcc ctt cgg acc agt cat gga gag gtc atc      678
 Pro Ser Gly Thr Leu Pro Ala Leu Arg Thr Ser His Gly Glu Val Ile
         200                 205                 210

 tca gtt cca cac aag atc atc acc cac ctt cga aaa gag gta cat act      726
 Ser Val Pro His Lys Ile Ile Thr His Leu Arg Lys Glu Val His Thr
     215                 220                 225

 ttt tgg ata gac acc aag aac tac gtg gaa gtg acc cgg aag tgg tat      774
 Phe Trp Ile Asp Thr Lys Asn Tyr Val Glu Val Thr Arg Lys Trp Tyr
 230                 235                 240                 245

 gca gag gct atg ccc ttt ccc ctc aac ttc ttc ctg cct ggc cgc atg      822
 Ala Glu Ala Met Pro Phe Pro Leu Asn Phe Phe Leu Pro Gly Arg Met
                 250                 255                 260

 cag cgg cag tac atg gaa cgg cta cag ctg ctg act ggg gag cac agg      870
 Gln Arg Gln Tyr Met Glu Arg Leu Gln Leu Leu Thr Gly Glu His Arg
             265                 270                 275

 cct gag gac gag gaa gag ctg gag aag gag ctg tac cga gag gct cgg      918
 Pro Glu Asp Glu Glu Glu Leu Glu Lys Glu Leu Tyr Arg Glu Ala Arg
         280                 285                 290

 gag tgt ctg acc ctg ctc tct cag cgc ctg ggc tct caa aag ttc ttc      966
 Glu Cys Leu Thr Leu Leu Ser Gln Arg Leu Gly Ser Gln Lys Phe Phe
     295                 300                 305

 ttt gga gat gcc cct gcc tcc ttg gac gcc ttc gtc ttc agc tac ttg     1014
 Phe Gly Asp Ala Pro Ala Ser Leu Asp Ala Phe Val Phe Ser Tyr Leu
 310                 315                 320                 325

 gcc ctg ctg ctg cag gca aag ctg ccc agt ggg aag ctg cag gtc cac     1062
 Ala Leu Leu Leu Gln Ala Lys Leu Pro Ser Gly Lys Leu Gln Val His
                 330                 335                 340

 ctg cgt ggg ctg cac aac ctc tgt gcc tat tgt acc cac att ctc agt     1110
 Leu Arg Gly Leu His Asn Leu Cys Ala Tyr Cys Thr His Ile Leu Ser
             345                 350                 355

 ctc tac ttc ccc tgg gat gga gct gag gta cca ccg caa cgc cag aca     1158
 Leu Tyr Phe Pro Trp Asp Gly Ala Glu Val Pro Pro Gln Arg Gln Thr
         360                 365                 370

 cca gca ggc cca gag act gag gag gag cca tac cgg cgc cgg aac cag     1206
 Pro Ala Gly Pro Glu Thr Glu Glu Glu Pro Tyr Arg Arg Arg Asn Gln
     375                 380                 385

 atc cta tct gtg ctg gca gga ctg gca gcc atg gtg ggc tac gcc ttg     1254
 Ile Leu Ser Val Leu Ala Gly Leu Ala Ala Met Val Gly Tyr Ala Leu
 390                 395                 400                 405

 ctc agc ggc att gtc tcc atc cag cgg gca acg cct gct cgg gcc cca     1302
 Leu Ser Gly Ile Val Ser Ile Gln Arg Ala Thr Pro Ala Arg Ala Pro
                 410                 415                 420

 ggc acc cgg acc ctg ggc atg gct gag gag gat gaa gag gaa tga ttt     1350
 Gly Thr Arg Thr Leu Gly Met Ala Glu Glu Asp Glu Glu Glu 
             425                 430                 435

 gtcctcacgc tcccaagact ggtttttcta ctctcatgca ttccagaggc ccccgtgcct   1410

 cctcgttgtt ggtacagccg gacacggggt gctgccaccc agaataaagc cactcacact   1470

 gaaaaaaaaa aaaaaa                                                   1486




      <210> 424
      <211> 524
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (180)..(470)

      <400> 424
 cgaagctggc cgcctgcggc atcgtcctca gcgcctgggg agtgatcatg ttgtaatcca     60

 cccaccgcca cttcaagaag aaatgatatg aagaagtgcc ggttctccct cccctcttcc    120

 gcactgtccc gtgatgatga cgcctccaga gaggacgata atctgggttc ctgggagag     179                                                                 
 atg gct tgg tca cta ttc cca ccc ttg cct cga cca ctt gtc tca atg      227
 Met Ala Trp Ser Leu Phe Pro Pro Leu Pro Arg Pro Leu Val Ser Met
   1               5                  10                  15

 tca cca cct cac gcc ctg ttc cag ata atg ctc gga ata ttt ttc aat      275
 Ser Pro Pro His Ala Leu Phe Gln Ile Met Leu Gly Ile Phe Phe Asn
              20                  25                  30

 gtc cat tcc gct gtg ttg att gag gac gtt ccc ttc acg gag aaa gat      323
 Val His Ser Ala Val Leu Ile Glu Asp Val Pro Phe Thr Glu Lys Asp
          35                  40                  45

 ttt gag aat ggc ccc cag aac ata tac aac ctt tac gag caa gtc agc      371
 Phe Glu Asn Gly Pro Gln Asn Ile Tyr Asn Leu Tyr Glu Gln Val Ser
      50                  55                  60

 tac aac tgt ttc atc gct gca ggc ctt tac ctc ctc ctc gga ggc ttc      419
 Tyr Asn Cys Phe Ile Ala Ala Gly Leu Tyr Leu Leu Leu Gly Gly Phe
  65                  70                  75                  80

 tct ttc tgc caa gtt cgg ctc aat aag cgc aag gaa tac atg gtg cgc      467
 Ser Phe Cys Gln Val Arg Leu Asn Lys Arg Lys Glu Tyr Met Val Arg
                  85                  90                  95

 tag gggc cccggcgcgt atcccccgat ccaggcccct cctctatcta aagactccct      524
 






      <210> 425
      <211> 3556
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (274)..(1680)

      <400> 425
 ttcccggggc caggaaaagc ctagggttaa catgcccaac gtggtttgca tttcctgcga     60

 agaaaggctt ttgtgtttac tctgaagagc tgggttccac tctaaacaat taggcaggta    120

 tttacccacc ccagaaaacg ggctgacttc ttcttcttct tttttttttt tgacggagtt    180

 ttgctttggg acggactttt ttaactttgg gacccaccaa agtttcagct acagatcccc    240

 ttacttacct ggaaaaaaag gccaggggcc cct atg ttc ggg gca ttg aaa aag     294
                                      Met Phe Gly Ala Leu Lys Lys
                                        1               5

 gaa cca ttt caa aag gtt aac ttt tca gtt ccg ggt ttg gtt tct ctg      342
 Glu Pro Phe Gln Lys Val Asn Phe Ser Val Pro Gly Leu Val Ser Leu
          10                  15                  20

 atc agt tca att tca ttt ttc agg tcg ggg agg ggg gcg aat aac tgg      390
 Ile Ser Ser Ile Ser Phe Phe Arg Ser Gly Arg Gly Ala Asn Asn Trp
      25                  30                  35

 att gaa att tat aat ttc gta cag caa ctt gcg gag aga ttt gtg agc      438
 Ile Glu Ile Tyr Asn Phe Val Gln Gln Leu Ala Glu Arg Phe Val Ser
  40                  45                  50                  55

 cct gaa atg aga tta tct ttc att gtg ttt tct tct caa gca act att      486
 Pro Glu Met Arg Leu Ser Phe Ile Val Phe Ser Ser Gln Ala Thr Ile
                  60                  65                  70

 att ttg cca tta act gga gac aga ggc aaa atc agt aaa ggc ttg gag      534
 Ile Leu Pro Leu Thr Gly Asp Arg Gly Lys Ile Ser Lys Gly Leu Glu
              75                  80                  85

 gat tta aaa cgt gtt agt cca gta gga gag aca tat atc cat gaa gga      582
 Asp Leu Lys Arg Val Ser Pro Val Gly Glu Thr Tyr Ile His Glu Gly
          90                  95                 100

 cta aag cta gcg aat gaa caa att cag aaa gca gga ggc ttg aaa acc      630
 Leu Lys Leu Ala Asn Glu Gln Ile Gln Lys Ala Gly Gly Leu Lys Thr
     105                 110                 115

 tcc agt atc ata att gct ctg aca gat ggc aag ttg gac ggt ctg gtg      678
 Ser Ser Ile Ile Ile Ala Leu Thr Asp Gly Lys Leu Asp Gly Leu Val
 120                 125                 130                 135

 cca tca tat gca gag aaa gag gca aag ata tcc agg tca ctt ggg gct      726
 Pro Ser Tyr Ala Glu Lys Glu Ala Lys Ile Ser Arg Ser Leu Gly Ala
                 140                 145                 150

 agt gtt tat tgt gtt ggg gtc ctt gat ttt gaa caa gca cag ctt gaa      774
 Ser Val Tyr Cys Val Gly Val Leu Asp Phe Glu Gln Ala Gln Leu Glu
             155                 160                 165

 aga att gct gat tcc aag gag caa gtt ttc cct gtc aaa ggt gga ttt      822
 Arg Ile Ala Asp Ser Lys Glu Gln Val Phe Pro Val Lys Gly Gly Phe
         170                 175                 180

 cag gct ctt aaa gga ata att aat tct ata cta gct cag tca tgt act      870
 Gln Ala Leu Lys Gly Ile Ile Asn Ser Ile Leu Ala Gln Ser Cys Thr
     185                 190                 195

 gaa atc cta gaa ttg cag ccc tca agt gtc tgt gtg ggg gag gaa ttt      918
 Glu Ile Leu Glu Leu Gln Pro Ser Ser Val Cys Val Gly Glu Glu Phe
 200                 205                 210                 215

 cag att gtc tta agt gga aga gga ttc atg ctg ggc agt cgg aat ggc      966
 Gln Ile Val Leu Ser Gly Arg Gly Phe Met Leu Gly Ser Arg Asn Gly
                 220                 225                 230

 agt gtt ctc tgc act tac act gta aat gaa aca tat aca acg agt gta     1014
 Ser Val Leu Cys Thr Tyr Thr Val Asn Glu Thr Tyr Thr Thr Ser Val
             235                 240                 245

 aaa cca gta agt gta cag ctt aat tct atg ctt tgt cct gca cct atc     1062
 Lys Pro Val Ser Val Gln Leu Asn Ser Met Leu Cys Pro Ala Pro Ile
         250                 255                 260

 ctg aat aaa gct gga gaa act ctt gat gtt tca gtg agc ttt aat gga     1110
 Leu Asn Lys Ala Gly Glu Thr Leu Asp Val Ser Val Ser Phe Asn Gly
     265                 270                 275

 gga aaa tct gtc att tca gga tca tta att gtc aca gcc aca gaa tgt     1158
 Gly Lys Ser Val Ile Ser Gly Ser Leu Ile Val Thr Ala Thr Glu Cys
 280                 285                 290                 295

 tct aac ggg atc gca gcc atc att gtt att ttg gtg tta ctg cta ctc     1206
 Ser Asn Gly Ile Ala Ala Ile Ile Val Ile Leu Val Leu Leu Leu Leu
                 300                 305                 310

 ctg ggg atc ggt ttg atg tgg tgg ttt tgg ccc ctt tgc tgc aaa gtg     1254
 Leu Gly Ile Gly Leu Met Trp Trp Phe Trp Pro Leu Cys Cys Lys Val
             315                 320                 325

 gtt att aag gat cct cca cca cca ccc ccc cct gca cca aaa gag gag     1302
 Val Ile Lys Asp Pro Pro Pro Pro Pro Pro Pro Ala Pro Lys Glu Glu
         330                 335                 340

 gaa gaa gaa cct ttg cct act aaa aag tgg cca act gtg gat gct tcc     1350
 Glu Glu Glu Pro Leu Pro Thr Lys Lys Trp Pro Thr Val Asp Ala Ser
     345                 350                 355

 tat tat ggt ggt cga ggg gtt gga gga att aaa aga atg gag gtt cgt     1398
 Tyr Tyr Gly Gly Arg Gly Val Gly Gly Ile Lys Arg Met Glu Val Arg
 360                 365                 370                 375

 tgg ggt gat aaa gga tct act gag gaa ggt gca agg cta gag aaa gcc     1446
 Trp Gly Asp Lys Gly Ser Thr Glu Glu Gly Ala Arg Leu Glu Lys Ala
                 380                 385                 390

 aaa aat gct gtg gtg aag att cct gaa gaa aca gag gaa ccc atc agg     1494
 Lys Asn Ala Val Val Lys Ile Pro Glu Glu Thr Glu Glu Pro Ile Arg
             395                 400                 405

 cct aga cca cct cga ccc aaa ccc aca cac cag cct cct cag aca aaa     1542
 Pro Arg Pro Pro Arg Pro Lys Pro Thr His Gln Pro Pro Gln Thr Lys
         410                 415                 420

 tgg tac acc cca att aag ggt cgt ctt gat gct ctc tgg gct ttg ttg     1590
 Trp Tyr Thr Pro Ile Lys Gly Arg Leu Asp Ala Leu Trp Ala Leu Leu
     425                 430                 435

 agg cgg cag tat gac cgg gtt tct ttg atg cga cct cag gaa gga gat     1638
 Arg Arg Gln Tyr Asp Arg Val Ser Leu Met Arg Pro Gln Glu Gly Asp
 440                 445                 450                 455

 gag ggc cgg tgc ata aac ttc tcc cga gtt cca tct cag taa aagggaa     1687
 Glu Gly Arg Cys Ile Asn Phe Ser Arg Val Pro Ser Gln 
                 460                 465

 gcaggaagac caagaaggta cgaagatggc acattttcac atagctgatt ttcaaccaaa   1747

 tgaaaaaaat caagtgcatt tcagaagctt ttggaagagc agcttaattc ctctcagtcg   1807

 ggaaatgttt tctctgcctt ctgctttgct tgcaccaaac atttctaaac acttgttctg   1867

 ccatctacat gggaggtgat gaaactcagt ggtaactcat gatttatgac attgaaaata   1927

 aagaggaaca ttgacctgca gactatggtt tgtacaagaa agtttgtttg aatgtgtaga   1987

 agaggaaaaa gcaacaacag caacaacacg aagatgatac caaaacaagg accacaaaac   2047

 aactagccat gatgggagac aggagttttt tacatggaaa catggcactt gtgtttttat   2107

 gtggcaagat ctttatccat aggcagagta tgaaatttcc caccaggcta agcaaataaa   2167

 gaagtccatt gccttatagc tatgtcagat cacagaatcc ttccaagtgc tctatcacag   2227

 tgtgccttat gggaagtttc tgactggaaa atcttgtcat tctaacactg aaaagtgcac   2287

 acgcatgaca aaatgtagac aagatgcctc aaggtattgg tagcaagcaa gattttgccc   2347

 tttagttttc gaagacacct ttctttcatt atgcactcgg gacaagaaaa ttaatagagc   2407

 gttattccac agaaggcctc tagccagaga tcttgagtgt agtgcaaggg actcatgctt   2467

 tgcgaacttg tccctgtgac tagtagattc ccccttttcc tgtgtttagg atttagtagt   2527

 gcataaagca ttaatatcca taaacatacc tagaagtttg ttttgctttt aatttaaagg   2587

 aagcagtaac cacaaagctt ccgctcaggg ttttttcttt cttcaagtct ccaagggctc   2647

 ttcagcgtca caaagccagc aactctcttt gcattaaaat ttcaaagttt aattaatata   2707

 attaaaagca acagcaagca gcagcctgtg aagattttgc tcatcttttt tatgcctttt   2767

 gacattgaat gacctattac tgtatgcgca ttacttggat tttgaggggc actctacctt   2827

 ggttatgatt cagtagagga aaaagaccac ctttcttcaa tttacaaatt aaatcttctg   2887

 gagggtcgct atcacaaaac attgacgatg tatgtattat aattttttag aaaaaccacc   2947

 atcgtgtcac gtcgacgatg ccaaattatg ttagcgtgag cagaaacacc gtgggggagg   3007

 aaggcagcag ctgaagaaaa aagctcaaat gatctagtca ctttcgatac tgtacttcag   3067

 atgcgaaatg gatattcgag tggaaacctg acaaagtgcg cctgctttga tgtgaactgg   3127

 tatagacaat gaccagtggc tgggtcagtg ggatgtctct ctgtgagcac aaaggcttat   3187

 caaatgacac taaagataag ttcaacaacc atcacattgg aagggagcag gcgaacattt   3247

 catgtttggc gggcatgtga gtgcacaaga tggaaagagc gattggagca tcctggtata   3307

 attaccccca ttgtgctctt aatggaaatt tcaaaggacg ggaggattct gttggttggt   3367

 gtccaggttt gtggcactgt tccaagaggc cttacacaca cacacaaata tataattttc   3427

 tatacatata tatcctctag cttgaaactt ttgctcaagt ttatttatgt cactggctgg   3487

 ctggatccaa agtcatgtgt ccacacattc ataaataaaa attttaccta tgaaaaaaaa   3547

 aaaaaaaaa                                                           3556




      <210> 426
      <211> 1790
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (274)..(1740)

      <400> 426
 ttcccggggc caggaaaagc ctagggttaa catgcccaac gtggtttgca tttcctgcga     60

 agaaaggctt ttgtgtttac tctgaagagc tgggttccac tctaaacaat taggcaggta    120

 tttacccacc ccagaaaacg ggctgacttc ttcttcttct tttttttttt tgacggagtt    180

 ttgctttggg acggactttt ttaactttgg gacccaccaa agtttcagct acagatcccc    240

 ttacttacct ggaaaaaaag gccaggggcc cct atg ttc ggg gca ttg aaa aag     294
                                      Met Phe Gly Ala Leu Lys Lys
                                        1               5

 gaa cca ttt caa aag gtt aac ttt tca gtt ccg ggt ttg gtt tct ctg      342
 Glu Pro Phe Gln Lys Val Asn Phe Ser Val Pro Gly Leu Val Ser Leu
          10                  15                  20

 atc agt tca att tca ttt ttc agg tcg ggg agg ggg gcg aat aac tgg      390
 Ile Ser Ser Ile Ser Phe Phe Arg Ser Gly Arg Gly Ala Asn Asn Trp
      25                  30                  35

 att gaa att tat aat ttc gta cag caa ctt gcg gag aga ttt gtg agc      438
 Ile Glu Ile Tyr Asn Phe Val Gln Gln Leu Ala Glu Arg Phe Val Ser
  40                  45                  50                  55

 cct gaa atg aga tta tct ttc att gtg ttt tct tct caa gca act att      486
 Pro Glu Met Arg Leu Ser Phe Ile Val Phe Ser Ser Gln Ala Thr Ile
                  60                  65                  70

 att ttg cca tta act gga gac aga ggc aaa atc agt aaa ggc ttg gag      534
 Ile Leu Pro Leu Thr Gly Asp Arg Gly Lys Ile Ser Lys Gly Leu Glu
              75                  80                  85

 gat tta aaa cgt gtt agt cca gta gga gag aca tat atc cat gaa gga      582
 Asp Leu Lys Arg Val Ser Pro Val Gly Glu Thr Tyr Ile His Glu Gly
          90                  95                 100

 cta aag cta gcg aat gaa caa att cag aaa gca gga ggc ttg aaa acc      630
 Leu Lys Leu Ala Asn Glu Gln Ile Gln Lys Ala Gly Gly Leu Lys Thr
     105                 110                 115

 tcc agt atc ata att gct ctg aca gat ggc aag ttg gac ggt ctg gtg      678
 Ser Ser Ile Ile Ile Ala Leu Thr Asp Gly Lys Leu Asp Gly Leu Val
 120                 125                 130                 135

 cca tca tat gca gag aaa gag gca aag ata tcc agg tca ctt ggg gct      726
 Pro Ser Tyr Ala Glu Lys Glu Ala Lys Ile Ser Arg Ser Leu Gly Ala
                 140                 145                 150

 agt gtt tat tgt gtt ggg gtc ctt gat ttt gaa caa gca cag ctt gaa      774
 Ser Val Tyr Cys Val Gly Val Leu Asp Phe Glu Gln Ala Gln Leu Glu
             155                 160                 165

 aga att gct gat tcc aag gag caa gtt ttc cct gtc aaa ggt gga ttt      822
 Arg Ile Ala Asp Ser Lys Glu Gln Val Phe Pro Val Lys Gly Gly Phe
         170                 175                 180

 cag gct ctt aaa gga ata att aat tct ata cta gct cag tca tgt act      870
 Gln Ala Leu Lys Gly Ile Ile Asn Ser Ile Leu Ala Gln Ser Cys Thr
     185                 190                 195

 gaa atc cta gaa ttg cag ccc tca agt gtc tgt gtg ggg gag gaa ttt      918
 Glu Ile Leu Glu Leu Gln Pro Ser Ser Val Cys Val Gly Glu Glu Phe
 200                 205                 210                 215

 cag att gtc tta agt gga aga gga ttc atg ctg ggc agt cgg aat ggc      966
 Gln Ile Val Leu Ser Gly Arg Gly Phe Met Leu Gly Ser Arg Asn Gly
                 220                 225                 230

 agt gtt ctc tgc act tac act gta aat gaa aca tat aca acg agt gta     1014
 Ser Val Leu Cys Thr Tyr Thr Val Asn Glu Thr Tyr Thr Thr Ser Val
             235                 240                 245

 aaa cca gta agt gta cag ctt aat tct atg ctt tgt cct gca cct atc     1062
 Lys Pro Val Ser Val Gln Leu Asn Ser Met Leu Cys Pro Ala Pro Ile
         250                 255                 260

 ctg aat aaa gct gga gaa act ctt gat gtt tca gtg agc ttt aat gga     1110
 Leu Asn Lys Ala Gly Glu Thr Leu Asp Val Ser Val Ser Phe Asn Gly
     265                 270                 275

 gga aaa tct gtc att tca gga tca tta att gtc aca gcc aca gaa tgt     1158
 Gly Lys Ser Val Ile Ser Gly Ser Leu Ile Val Thr Ala Thr Glu Cys
 280                 285                 290                 295

 tct aac ggg atc gca gcc atc att gtt att ttg gtg tta ctg cta ctc     1206
 Ser Asn Gly Ile Ala Ala Ile Ile Val Ile Leu Val Leu Leu Leu Leu
                 300                 305                 310

 ctg ggg atc ggt ttg atg tgg tgg ttt tgg ccc ctt tgc tgc aaa gtg     1254
 Leu Gly Ile Gly Leu Met Trp Trp Phe Trp Pro Leu Cys Cys Lys Val
             315                 320                 325

 gtt att aag gat cct cca cca cca ccc ccc cct gca cca aaa gag gag     1302
 Val Ile Lys Asp Pro Pro Pro Pro Pro Pro Pro Ala Pro Lys Glu Glu
         330                 335                 340

 gaa gaa gaa cct ttg cct act aaa aag tgg cca act gtg gat gct tcc     1350
 Glu Glu Glu Pro Leu Pro Thr Lys Lys Trp Pro Thr Val Asp Ala Ser
     345                 350                 355

 tat tat ggt ggt cga ggg gtt gga gga att aaa aga atg gag gtt cgt     1398
 Tyr Tyr Gly Gly Arg Gly Val Gly Gly Ile Lys Arg Met Glu Val Arg
 360                 365                 370                 375

 tgg ggt gat aaa gga tct act gag gaa ggt gca agg cta gag aaa gcc     1446
 Trp Gly Asp Lys Gly Ser Thr Glu Glu Gly Ala Arg Leu Glu Lys Ala
                 380                 385                 390

 aaa aat gct gtg gtg aag att cct gaa gaa aca gag gaa ccc atc agg     1494
 Lys Asn Ala Val Val Lys Ile Pro Glu Glu Thr Glu Glu Pro Ile Arg
             395                 400                 405

 cct aga cca cct cga ccc aaa ccc aca cac cag cct cct cag aca aaa     1542
 Pro Arg Pro Pro Arg Pro Lys Pro Thr His Gln Pro Pro Gln Thr Lys
         410                 415                 420

 tgg tac acc cca att aag ggt cgt ctt gat gct ctc tgg gct ttg ttg     1590
 Trp Tyr Thr Pro Ile Lys Gly Arg Leu Asp Ala Leu Trp Ala Leu Leu
     425                 430                 435

 agg cgg cag tat gac cgg gtt tct ttg atg cga cct cag gaa gga gat     1638
 Arg Arg Gln Tyr Asp Arg Val Ser Leu Met Arg Pro Gln Glu Gly Asp
 440                 445                 450                 455

 gag ggc cgg tgc ata aac ttc tcc cga gtt cca tct cag ttg att ttc     1686
 Glu Gly Arg Cys Ile Asn Phe Ser Arg Val Pro Ser Gln Leu Ile Phe
                 460                 465                 470

 aac caa atg aaa aaa atc aag tgc att tca gaa gct ttt gga aga gca     1734
 Asn Gln Met Lys Lys Ile Lys Cys Ile Ser Glu Ala Phe Gly Arg Ala
             475                 480                 485

 gct taa ttcctctcag tcgggaaatg ttttctctgc cttctgcttt gcttgcacca      1790
 Ala 






      <210> 427
      <211> 1892
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (32)..(1465)

      <400> 427
 cgccgctggg taggcggaag tagccgcagg c   atg gcg gcg gct atg ccg ctt      52
                                      Met Ala Ala Ala Met Pro Leu
                                        1               5

 gct ctg ctc gtc ctg ttg ctc ctg ggg ccc ggc ggc tgg tgc ctt gca      100
 Ala Leu Leu Val Leu Leu Leu Leu Gly Pro Gly Gly Trp Cys Leu Ala
          10                  15                  20

 gaa ccc cca cgc gac agc ctg cgg gag gaa ctt gtc atc acc ccg ctg      148
 Glu Pro Pro Arg Asp Ser Leu Arg Glu Glu Leu Val Ile Thr Pro Leu
      25                  30                  35

 cct tcc ggg gac gta gcc gcc aca ttc cag ttc cgc acg cgc tgg gat      196
 Pro Ser Gly Asp Val Ala Ala Thr Phe Gln Phe Arg Thr Arg Trp Asp
  40                  45                  50                  55

 tcg gag ctt cag cgg gaa gga gac act gac cac tac ttt ctg cgc tat      244
 Ser Glu Leu Gln Arg Glu Gly Asp Thr Asp His Tyr Phe Leu Arg Tyr
                  60                  65                  70

 gct gtg ctg ccg cgg gag gtg gtc tgc acc gaa aac ctc acc ccc tgg      292
 Ala Val Leu Pro Arg Glu Val Val Cys Thr Glu Asn Leu Thr Pro Trp
              75                  80                  85

 aag aag ctc ttg ccc tgt agt tcc aag gca ggc ctc tct gtg ctg ctg      340
 Lys Lys Leu Leu Pro Cys Ser Ser Lys Ala Gly Leu Ser Val Leu Leu
          90                  95                 100

 aag gcc agg atc gct tgt tcc aca cca gct acc act ccc agg cag tgg      388
 Lys Ala Arg Ile Ala Cys Ser Thr Pro Ala Thr Thr Pro Arg Gln Trp
     105                 110                 115

 cat atc cgc cct gtt tgc aga aat gca cgc tgt act agc atc tcc tgg      436
 His Ile Arg Pro Val Cys Arg Asn Ala Arg Cys Thr Ser Ile Ser Trp
 120                 125                 130                 135

 gag ctg agg cag acc ctg tca gtt gta ttt gat gcc ttc atc acg ggg      484
 Glu Leu Arg Gln Thr Leu Ser Val Val Phe Asp Ala Phe Ile Thr Gly
                 140                 145                 150

 cag gga aag aaa gac tgg tcc ctc ttc cgg atg ttc tcc cga acc ctc      532
 Gln Gly Lys Lys Asp Trp Ser Leu Phe Arg Met Phe Ser Arg Thr Leu
             155                 160                 165

 acg gag ccc tgc ccc ctg gct tca gag agc cga gtc tat gtg gac atc      580
 Thr Glu Pro Cys Pro Leu Ala Ser Glu Ser Arg Val Tyr Val Asp Ile
         170                 175                 180

 acc acc tac aac cag gac aac gag aca tta gag gtg cac cca ccc ccg      628
 Thr Thr Tyr Asn Gln Asp Asn Glu Thr Leu Glu Val His Pro Pro Pro
     185                 190                 195

 acc act aca tat cag gac gtc atc cta ggc act cgg aag acc tat gcc      676
 Thr Thr Thr Tyr Gln Asp Val Ile Leu Gly Thr Arg Lys Thr Tyr Ala
 200                 205                 210                 215

 atc tat gac ttg ctt gac acc gcc atg atc aac aac tct cga aac ctc      724
 Ile Tyr Asp Leu Leu Asp Thr Ala Met Ile Asn Asn Ser Arg Asn Leu
                 220                 225                 230

 aac atc cag ctc aag tgg aag aga ccc cca gag aat gag gcc ccc cca      772
 Asn Ile Gln Leu Lys Trp Lys Arg Pro Pro Glu Asn Glu Ala Pro Pro
             235                 240                 245

 gtg ccc ttc ctg cat gcc cag cgg tac gtg agt ggc tat ggg ctg cag      820
 Val Pro Phe Leu His Ala Gln Arg Tyr Val Ser Gly Tyr Gly Leu Gln
         250                 255                 260

 aag ggg gag ctg agc aca ctg ctg tac aac acc cac cca tac cgg gcc      868
 Lys Gly Glu Leu Ser Thr Leu Leu Tyr Asn Thr His Pro Tyr Arg Ala
     265                 270                 275

 ttc ccg gtg ctg ctg ctg gac acc gta ccc tgg tat ctg cgg ctg tat      916
 Phe Pro Val Leu Leu Leu Asp Thr Val Pro Trp Tyr Leu Arg Leu Tyr
 280                 285                 290                 295

 gtg cac acc ctc acc atc acc tcc aag ggc aag gag aac aaa cca agt      964
 Val His Thr Leu Thr Ile Thr Ser Lys Gly Lys Glu Asn Lys Pro Ser
                 300                 305                 310

 tac atc cac tac cag cct gcc cag gac cgg ctg caa ccc cac ctc ctg     1012
 Tyr Ile His Tyr Gln Pro Ala Gln Asp Arg Leu Gln Pro His Leu Leu
             315                 320                 325

 gag atg ctg att cag ctg ccg gcc aac tca gtc acc aag gtt tcc atc     1060
 Glu Met Leu Ile Gln Leu Pro Ala Asn Ser Val Thr Lys Val Ser Ile
         330                 335                 340

 cag ttt gag cgg gcg ctg ctg aag tgg acc gag tac acg cca gat cct     1108
 Gln Phe Glu Arg Ala Leu Leu Lys Trp Thr Glu Tyr Thr Pro Asp Pro
     345                 350                 355

 aac cat ggc ttc tat gtc agc cca tct gtc ctc agc gcc ctt gtg ccc     1156
 Asn His Gly Phe Tyr Val Ser Pro Ser Val Leu Ser Ala Leu Val Pro
 360                 365                 370                 375

 agc atg gta gca gcc aag cca gtg gac tgg gaa gag agt ccc ctc ttc     1204
 Ser Met Val Ala Ala Lys Pro Val Asp Trp Glu Glu Ser Pro Leu Phe
                 380                 385                 390

 aac agc ctg ttc cca gtc tct gat ggc tct aac tac ttt gtg cgg ctc     1252
 Asn Ser Leu Phe Pro Val Ser Asp Gly Ser Asn Tyr Phe Val Arg Leu
             395                 400                 405

 tac acg gag ccg ctg ctg gtg aac ctg ccg aca ccg gac ttc agc atg     1300
 Tyr Thr Glu Pro Leu Leu Val Asn Leu Pro Thr Pro Asp Phe Ser Met
         410                 415                 420

 ccc tac aac gtg atc tgc ctc acg tgc act gtg gtg gcc gtg tgc tac     1348
 Pro Tyr Asn Val Ile Cys Leu Thr Cys Thr Val Val Ala Val Cys Tyr
     425                 430                 435

 ggc tcc ttc tac aat ctc ctc acc cga acc ttc cac atc gag gag ccc     1396
 Gly Ser Phe Tyr Asn Leu Leu Thr Arg Thr Phe His Ile Glu Glu Pro
 440                 445                 450                 455

 cgc aca ggt ggc ctg gcc aag cgg ctg gcc aac ctt atc cgg cgc gcc     1444
 Arg Thr Gly Gly Leu Ala Lys Arg Leu Ala Asn Leu Ile Arg Arg Ala
                 460                 465                 470

 cga ggt gtc ccc cca ctc tga tt cttgcccttt ccagcagctg cagctgccgt     1497
 Arg Gly Val Pro Pro Leu 
             475

 ttctctctgg ggaggggagc ccaagggctg tttctgccac ttgctctcct cagagttggc   1557

 ttttgaacca aagtgccctg gaccaggtca gggcctacag ctgtgttgtc cagtacagga   1617

 gccacgagcc aaatgtggca tttgaatttg aattaactta gaaattcatt tcctcacctg   1677

 tagtggccac ctctatattg aggtgctcaa taagcaaaag tggtcggtgg ctgctgtatt   1737

 ggacagccca gaaaaaaatt tccctccccc caaaaaggtc ggctggcagc actggccaag   1797

 gtgatggggt gtgctacaca gtgtatgtca ctgtgtagtg gatggagttt actgtttgtg   1857

 gaataaaaac ggctgtttcc gtgaaaaaaa aaaaa                              1892




      <210> 428
      <211> 1872
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (1)..(696)

      <400> 428
  atg gcc cgg ctg ggc gcg ctg ctc ctg gcc gcc gcc ctg ggt gca ctg      48
  Met Ala Arg Leu Gly Ala Leu Leu Leu Ala Ala Ala Leu Gly Ala Leu
    1               5                  10                  15

 ctc agc ttc gcg ctc ctg gcc gcc gcg gtc gcc agc gac tac tgg tac       96
 Leu Ser Phe Ala Leu Leu Ala Ala Ala Val Ala Ser Asp Tyr Trp Tyr
              20                  25                  30

 atc ctg gag gtg gcg gac gcc ggc aat ggc agc gcc tgg ccc ggg cgc      144
 Ile Leu Glu Val Ala Asp Ala Gly Asn Gly Ser Ala Trp Pro Gly Arg
          35                  40                  45

 gca gag ctg ctc tcc tcg cac tcg ggg ctc tgg cgc atc tgc gaa agg      192
 Ala Glu Leu Leu Ser Ser His Ser Gly Leu Trp Arg Ile Cys Glu Arg
      50                  55                  60

 ctt cga ggc cta tgt ttc cca ggg cag aac ggc tgc atc ccg ctg gtc      240
 Leu Arg Gly Leu Cys Phe Pro Gly Gln Asn Gly Cys Ile Pro Leu Val
  65                  70                  75                  80

 gac cct ttt gcc agt gag agc ctg gac gtc tcc acc tcg gtg cag cac      288
 Asp Pro Phe Ala Ser Glu Ser Leu Asp Val Ser Thr Ser Val Gln His
                  85                  90                  95

 ctc atc ttg ctg cac cgt gca gtc att gtg gtc ctg ccc ctg agc ctg      336
 Leu Ile Leu Leu His Arg Ala Val Ile Val Val Leu Pro Leu Ser Leu
             100                 105                 110

 gtc ctt ctc gtg tgt ggc tgg atc tgc ggc ctg ctc agc tcc ctg gcc      384
 Val Leu Leu Val Cys Gly Trp Ile Cys Gly Leu Leu Ser Ser Leu Ala
         115                 120                 125

 cag agc gtg tct ctg ctg ctt ttc acc ggc tgc tac ttc ctg ctg ggg      432
 Gln Ser Val Ser Leu Leu Leu Phe Thr Gly Cys Tyr Phe Leu Leu Gly
     130                 135                 140

 agt gtc ctg aca ctg gcg ggg gtc agc atc tac atc agc tac tcg cac      480
 Ser Val Leu Thr Leu Ala Gly Val Ser Ile Tyr Ile Ser Tyr Ser His
 145                 150                 155                 160

 ctg gcc ttt gcg gag acg gtg cag cag tat ggc ccg cag cac atg cag      528
 Leu Ala Phe Ala Glu Thr Val Gln Gln Tyr Gly Pro Gln His Met Gln
                 165                 170                 175

 ggc gtc cgc gtc agc ttc ggc tgg tcc atg gcc ctg gcc tgg ggc tcc      576
 Gly Val Arg Val Ser Phe Gly Trp Ser Met Ala Leu Ala Trp Gly Ser
             180                 185                 190

 tgt gcc ttg gag gca ttc agc gga acc ctc ctg ctc tca gct gcc tgg      624
 Cys Ala Leu Glu Ala Phe Ser Gly Thr Leu Leu Leu Ser Ala Ala Trp
         195                 200                 205

 acc ctc agc ctg agc ccc cca atc tgt ggt cat ctg agt ccc cag cag      672
 Thr Leu Ser Leu Ser Pro Pro Ile Cys Gly His Leu Ser Pro Gln Gln
     210                 215                 220

 gtg gga ggg aga ggg gga gac tga ggcccagagc ggcagaggga cccacccaga     726
 Val Gly Gly Arg Gly Gly Asp 
 225                 230

 tcgcctggcg ccagagagat gccgtctcag gccaaggcct ccctggcctc tgttctgtcc    786

 actctccccg aagggcaggc ttggtggaga agaggctgat gagagggccc gagagcccct    846

 ccgatttgca ggggtggggg gcaaggagct gagcgatcca gatgtacccc tctgccccct    906

 cccttgttct caagcctgct aggtactttt cactgagcac ttccgggaag agcaggcacc    966

 cagatctctg tccttgtcct ggcacaggct gctgctgctt ccggcccccg acccttcctc   1026

 tctgcagcaa cccgggggag gtatgccact gtgagtgccc tggtgggcac actgagctgg   1086

 cagagatgga agtcccagaa gggtggggtg ggggtgtcat gccatggtgg aggagtttgg   1146

 ggccactcct tgcctgcctc aaagggggcc tggctgaggg tgcttcttga ccacaggggc   1206

 cagggctgcc tagggtggcg cagggctggg cctggagttt gggatgcagg cttgttaaac   1266

 acagggcaga accccaggtt gggaggggct cagtttgcag gcccaggccc gcaggcccac   1326

 tgctggtccc agggtgagac aggtgagaag agggatggcc agcacacact tgagtcccct   1386

 tgggccacaa aggctggggc acgcccaccg ttatgcagat ggacagttga ggtggctgca   1446

 ggagaagggt tcccagggcc tgtacaacac gtggaagcac taaacggccc cgtttggggt   1506

 ttgggggccc ttcccgagtc ttgagaggtc ttgagaggtg tgctggggaa ggtggcagcc   1566

 tcttgtagct tgatcttcct ccaccctgcc ccacccctag gtctctttat tgattcaaag   1626

 gttaaggaag ctcctggggg cttgaggggg tggcacagtt ttggtggggc ccagtgagga   1686

 caaatctggg gggtgagcag ggcctcctct tcctcctggt gtttgaacgt ttaccattcc   1746

 atgtgggacc attgtgccaa tttgtcctta cgtaaatcac ttgtgctgtg tgcagtataa   1806

 gccttttatt tttcttagaa cttttcaaaa taggtaacac atgcctgtct gtcataaaca   1866

 gatcaa                                                              1872




      <210> 429
      <211> 774
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (1)..(774)

      <400> 429
  atg gcc cgg ctg ggc gcg ctg ctc ctg gcc gcc gcc ctg ggt gca ctg      48
  Met Ala Arg Leu Gly Ala Leu Leu Leu Ala Ala Ala Leu Gly Ala Leu
    1               5                  10                  15

 ctc agc ttc gcg ctc ctg gcc gcc gcg gtc gcc agc gac tac tgg tac       96
 Leu Ser Phe Ala Leu Leu Ala Ala Ala Val Ala Ser Asp Tyr Trp Tyr
              20                  25                  30

 atc ctg gag gtg gcg gac gcc ggc aat ggc agc gcc tgg ccc ggg cgc      144
 Ile Leu Glu Val Ala Asp Ala Gly Asn Gly Ser Ala Trp Pro Gly Arg
          35                  40                  45

 gca gag ctg ctc tcc tcg cac tcg ggg ctc tgg cgc atc tgc ggg cag      192
 Ala Glu Leu Leu Ser Ser His Ser Gly Leu Trp Arg Ile Cys Gly Gln
      50                  55                  60

 aac ggc tgc atc ccg ctg gtc gac cct ttt gcc agt gag agc ctg gac      240
 Asn Gly Cys Ile Pro Leu Val Asp Pro Phe Ala Ser Glu Ser Leu Asp
  65                  70                  75                  80

 gtc tcc acc tcg gtg cag cac ctc atc ttg ctg cac cgt gca gtc att      288
 Val Ser Thr Ser Val Gln His Leu Ile Leu Leu His Arg Ala Val Ile
                  85                  90                  95

 gtg gtc ctg ccc ctg agc ctg gtc ctt ctc gtg tgt ggc tgg atc tgc      336
 Val Val Leu Pro Leu Ser Leu Val Leu Leu Val Cys Gly Trp Ile Cys
             100                 105                 110

 ggc ctg ctc agc tcc ctg gcc cag agc gtg tct ctg ctg ctt ttc acc      384
 Gly Leu Leu Ser Ser Leu Ala Gln Ser Val Ser Leu Leu Leu Phe Thr
         115                 120                 125

 ggc tgc tac ttc ctg ctg ggg agt gtc ctg aca ctg gcg ggg gtc agc      432
 Gly Cys Tyr Phe Leu Leu Gly Ser Val Leu Thr Leu Ala Gly Val Ser
     130                 135                 140

 atc tac atc agc tac tcg cac ctg gcc ttt gcg gag acg gtg cag cag      480
 Ile Tyr Ile Ser Tyr Ser His Leu Ala Phe Ala Glu Thr Val Gln Gln
 145                 150                 155                 160

 tat ggc ccg cag cac atg cag ggc gtc cgc gtc agc ttc ggc tgg tcc      528
 Tyr Gly Pro Gln His Met Gln Gly Val Arg Val Ser Phe Gly Trp Ser
                 165                 170                 175

 atg gcc ctg gcc tgg ggc tcc tgt gcc ttg gag gca ttc agc gga acc      576
 Met Ala Leu Ala Trp Gly Ser Cys Ala Leu Glu Ala Phe Ser Gly Thr
             180                 185                 190

 ctc ctg ctc tca gct gcc tgg acc ctc agc ctg agc ccc cca atc tgt      624
 Leu Leu Leu Ser Ala Ala Trp Thr Leu Ser Leu Ser Pro Pro Ile Cys
         195                 200                 205

 ggt cat ctg agt ccc cag cag ggc agg ctt ggt gga gaa gag gct gat      672
 Gly His Leu Ser Pro Gln Gln Gly Arg Leu Gly Gly Glu Glu Ala Asp
     210                 215                 220

 gag agg gcc cga gag ccc ctc cga ttt gca ggg gtg ggg ggc aag gag      720
 Glu Arg Ala Arg Glu Pro Leu Arg Phe Ala Gly Val Gly Gly Lys Glu
 225                 230                 235                 240

 ctg agc gat cca gat gta ccc ctc tgc ccc ctc cct tgt tct caa gcc      768
 Leu Ser Asp Pro Asp Val Pro Leu Cys Pro Leu Pro Cys Ser Gln Ala
                 245                 250                 255

 tgc tag                                                              774
 Cys 






      <210> 430
      <211> 1336
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (109)..(849)

      <400> 430
 agtggtacca acgcaaagta cgcggggagt ctcgcgatag ccagccgcgg ctgcccttgc     60

 gcttcccgag ctggcggggt ccgtggtgcg ggatcgagat tgcgggct atg gcg ccg     117
                                                      Met Ala Pro
                                                        1

 aag gtt ttt cgt cag tac tgg gat atc ccc gat ggc acc gat tgc cac      165
 Lys Val Phe Arg Gln Tyr Trp Asp Ile Pro Asp Gly Thr Asp Cys His
       5                  10                  15

 cgc aaa gcc tac agc acc acc agt att gcc agc gtc gct ggc ctg acc      213
 Arg Lys Ala Tyr Ser Thr Thr Ser Ile Ala Ser Val Ala Gly Leu Thr
  20                  25                  30                  35

 gcc gct gcc tac aga gtc aca ctc aat cct ccg ggc acc ttc ctt gaa      261
 Ala Ala Ala Tyr Arg Val Thr Leu Asn Pro Pro Gly Thr Phe Leu Glu
                  40                  45                  50

 gga gtg gct aag gtt gga caa tac acg ttc act gca gct gct gtc ggg      309
 Gly Val Ala Lys Val Gly Gln Tyr Thr Phe Thr Ala Ala Ala Val Gly
              55                  60                  65

 gcc gtg ttt ggc ctc acc acc tgc atc agc gcc cat gtc cgc gag aag      357
 Ala Val Phe Gly Leu Thr Thr Cys Ile Ser Ala His Val Arg Glu Lys
          70                  75                  80

 ccc gac gac ccc ctg aac tac ttc ctc ggt ggc tgc gcc gga ggc ctg      405
 Pro Asp Asp Pro Leu Asn Tyr Phe Leu Gly Gly Cys Ala Gly Gly Leu
      85                  90                  95

 act ctg gga gca cgc acg cac aac tac ggg att ggc gcc gcc gcc tgc      453
 Thr Leu Gly Ala Arg Thr His Asn Tyr Gly Ile Gly Ala Ala Ala Cys
 100                 105                 110                 115

 gtg tac ttt ggc ata gcg gcc tcc ctg gtc aag atg ggc cgg ctg gag      501
 Val Tyr Phe Gly Ile Ala Ala Ser Leu Val Lys Met Gly Arg Leu Glu
                 120                 125                 130

 gtc tgt gag cac tgc gtg gag gga gac aga gcg cgc aat ctc tcc agc      549
 Val Cys Glu His Cys Val Glu Gly Asp Arg Ala Arg Asn Leu Ser Ser
             135                 140                 145

 tgc atg tgg gag cag tgc cgg cca gag gag cca gga cac tgt gtg gcc      597
 Cys Met Trp Glu Gln Cys Arg Pro Glu Glu Pro Gly His Cys Val Ala
         150                 155                 160

 caa tct gag gtg gtc aag gaa ggt tgc tcc atc tac aac cgc tca gag      645
 Gln Ser Glu Val Val Lys Glu Gly Cys Ser Ile Tyr Asn Arg Ser Glu
     165                 170                 175

 gca tgt cca gct gct cac cac cac ccc acc tat gaa ccg aag aca gtc      693
 Ala Cys Pro Ala Ala His His His Pro Thr Tyr Glu Pro Lys Thr Val
 180                 185                 190                 195

 aca aca ggg agc ccc cca gtc cct gag gcc cac agc cct gga ttt gac      741
 Thr Thr Gly Ser Pro Pro Val Pro Glu Ala His Ser Pro Gly Phe Asp
                 200                 205                 210

 ggg gcc agc ttt atc gga ggt gtc gtg ctg gtg ttg agc cta cag gcg      789
 Gly Ala Ser Phe Ile Gly Gly Val Val Leu Val Leu Ser Leu Gln Ala
             215                 220                 225

 gtg gct ttc ttt gtg ctg cac ttc ctc aag gcc aag gac agc acc tac      837
 Val Ala Phe Phe Val Leu His Phe Leu Lys Ala Lys Asp Ser Thr Tyr
         230                 235                 240

 cag acg ctg tga gta cctggccagc agcaagtacc tgagtcccag ctcacctcct      892
 Gln Thr Leu 
     245

 ggttcctgcc ccaccgttcc ccttcagtac ccagggtgct gtcttctcca tgggcaagcc    952

 ctcaggacgg tgacagcgtg ctccatgtga gccacacccc ttttgtctcc tccagttggg   1012

 gtgtttcctt tgtcagatgt tggctgggac caggactcag cctgggccag tctaggagcc   1072

 cagctgagcc ctcctgtgtc ttttcccttc atgctgccag cagggaagag aaccagtagg   1132

 tgccagccca ggcaagcctg tggcccgcgt ttctgtggct gtgggcagga gctgggcctt   1192

 gtgtctagtt gggttttgct ctgagaaggg gagctgtgct gaggccctct gtgtgccgtg   1252

 tgtgctgtgg ggcgggtcgc cacagcctgt gttaaagtgt ttgctcttcc tctgctgcct   1312

 catctctgag gggggcccgt tata                                          1336




      <210> 431
      <211> 1833
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (1042)..(1767)

      <400> 431
 gatgactcag gagtttaggc tgcagcttca ggacgcaaat cagcacacct ctgcccccaa     60

 atctgctgga ctacgggaga gtctatggga caggcccggg gcaggatcct gccccaccta    120

 taccacccaa tctctcagac ttcggatcct ctgggcccca gttttgcagt atgcgtgtat    180

 gtgtgcgtgc ggccacgcgc tcgctaggag cgtgtggttc gagaccccaa atcttcccat    240

 acgcaggccc ccgggagtct acaggatggc ggctgaggcg ggaggacatt ttcagcaccg    300

 gacgacggac agcacccgcg cggagaagag gagtgggagg cgggtggagt cagcatcctg    360

 gggcttgctt ggcagctctg tcactgatag gtccggcctc ccaccaccac ctccgggtct    420

 gccggggctc cgttccaaga ttgggtgaag tgtaggtgac gggggaggaa aacaagccca    480

 gagagggaga aacaggcgcc ccgaagggca gggcttggtt ggaactcgac cgccccgttc    540

 cctcctggag tacgtcccac caaggaagct ttgctcctga ctccggctgc aggttacctc    600

 tcgactccct ggtgtagtcg tggcagggtg cgtcaagtgc ctcaccgcgc aggcgcgcaa    660

 ataattctcg cccaccttct ttcttaactc ttctattggc tgttcccacc gtgaactggc    720

 aagcccgtga tccaatccca ggcaccgcaa gtcgctccgc ctgtccctca cccggatgtt    780

 gccttctgcc gaatccgctc aggccagagc tcgtcagtgg ccaattggga gaggggaggg    840

 gcgagccggc gccgccgaag agccaatggc aggcgcgggg gatgacgcca cggacatggt    900

 ggccgagacc ggcggggtgg gggacgtgtc gcgcggccgg gtggcctcgg tcggtaccct    960

 gggcgcggag cagctgcctc attagtattc gtacccacga ggcggcgcag cgggccctcg   1020

 gggacagcga gcgtcgcggc c  atg gct tat cac tcg ggc tac gga gcc cac    1071
                          Met Ala Tyr His Ser Gly Tyr Gly Ala His
                            1               5                  10

 ggc tcc aag cac agg gcc cgg gca gcc ccg gat ccc cct ccc ctc ttc     1119
 Gly Ser Lys His Arg Ala Arg Ala Ala Pro Asp Pro Pro Pro Leu Phe
                  15                  20                  25

 gat gac aca agc ggt ggt tat tcc agc cag ccc ggg gga tac cca gcc     1167
 Asp Asp Thr Ser Gly Gly Tyr Ser Ser Gln Pro Gly Gly Tyr Pro Ala
              30                  35                  40

 aca gga gca gac gtg gcc ttc agt gtc aac cac ttg ctt ggg gac cca     1215
 Thr Gly Ala Asp Val Ala Phe Ser Val Asn His Leu Leu Gly Asp Pro
          45                  50                  55

 atg gcc aat gtg gct atg gcc tat ggc agc tcc atc gca tcc cat ggg     1263
 Met Ala Asn Val Ala Met Ala Tyr Gly Ser Ser Ile Ala Ser His Gly
      60                  65                  70

 aag gac atg gtg cac aag gag ctg cac cgt ttt gtg tct gtg agc aaa     1311
 Lys Asp Met Val His Lys Glu Leu His Arg Phe Val Ser Val Ser Lys
  75                  80                  85                  90

 ctc aag tat ttt ttt gct gtg gac aca gcc tac gtg gcc aag aag cta     1359
 Leu Lys Tyr Phe Phe Ala Val Asp Thr Ala Tyr Val Ala Lys Lys Leu
                  95                 100                 105

 ggg ctg ctg gtc ttc ccc tac aca cac cag aac tgg gaa gtg cag tac     1407
 Gly Leu Leu Val Phe Pro Tyr Thr His Gln Asn Trp Glu Val Gln Tyr
             110                 115                 120

 agt cgt gat gct cct ctg ccc ccc cgg caa gac ctc aac gcc cct gac     1455
 Ser Arg Asp Ala Pro Leu Pro Pro Arg Gln Asp Leu Asn Ala Pro Asp
         125                 130                 135

 ctc tat atc ccc acg atg gcc ttc att act tac gtg ctc ctg gct ggg     1503
 Leu Tyr Ile Pro Thr Met Ala Phe Ile Thr Tyr Val Leu Leu Ala Gly
     140                 145                 150

 atg gca ctg ggc att cag aaa aga atg atc ctc agt gtg ctc acg ggg     1551
 Met Ala Leu Gly Ile Gln Lys Arg Met Ile Leu Ser Val Leu Thr Gly
 155                 160                 165                 170

 ctg ctg ttc ggc agc gat ggc tac tac gtg gcg ctg gcc tgg acc tca     1599
 Leu Leu Phe Gly Ser Asp Gly Tyr Tyr Val Ala Leu Ala Trp Thr Ser
                 175                 180                 185

 tcg gcg ctc atg tac ttc att gtg cgc tct ttg cgg aca gca gcc ctg     1647
 Ser Ala Leu Met Tyr Phe Ile Val Arg Ser Leu Arg Thr Ala Ala Leu
             190                 195                 200

 ggc ccc gac agc atg ggg ggc ccc gtc ccc cgg cag cgt ctc cag ctc     1695
 Gly Pro Asp Ser Met Gly Gly Pro Val Pro Arg Gln Arg Leu Gln Leu
         205                 210                 215

 tac ctg act ctg gga gct gca gcc ttc cag ccc ctc atc ata tac tgg     1743
 Tyr Leu Thr Leu Gly Ala Ala Ala Phe Gln Pro Leu Ile Ile Tyr Trp
     220                 225                 230

 ctg act ttc cac ctg gtc cgg tga ccccctggcc ccagatggca ctgagttttt    1797
 Leu Thr Phe His Leu Val Arg 
 235                 240

 cattcattga agatttgatt tccttgaaaa aaaaaa                             1833




      <210> 432
      <211> 1122
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (43)..(1122)

      <400> 432
 ctgttcactg gtgcatttat tttggatttg accatctggg ga   atg ggt gtg gcc      54
                                                  Met Gly Val Ala
                                                    1

 tct cct ggc ctc tcc ctc cct ggg gcc cag gca ggg aga atg tct cag      102
 Ser Pro Gly Leu Ser Leu Pro Gly Ala Gln Ala Gly Arg Met Ser Gln
   5                  10                  15                  20

 aat gac ttc ctt gag agt cct gct ccc ctt tca tca atg cac aga tac      150
 Asn Asp Phe Leu Glu Ser Pro Ala Pro Leu Ser Ser Met His Arg Tyr
                  25                  30                  35

 aga aga ccc ctc cgt cat gca gca tct gcc atg agc atc ggc ctc ctg      198
 Arg Arg Pro Leu Arg His Ala Ala Ser Ala Met Ser Ile Gly Leu Leu
              40                  45                  50

 tgc tgt gca gcc ttg tct ctc ctg tgg gca ggt cca gtg aat gct ggt      246
 Cys Cys Ala Ala Leu Ser Leu Leu Trp Ala Gly Pro Val Asn Ala Gly
          55                  60                  65

 gtc act cag acc cca aaa ttc cag gtc ctg aag aca gga cag agc atg      294
 Val Thr Gln Thr Pro Lys Phe Gln Val Leu Lys Thr Gly Gln Ser Met
      70                  75                  80

 aca ctg cag tgt gcc cag gat atg aac cat gaa tac atg tcc tgg tat      342
 Thr Leu Gln Cys Ala Gln Asp Met Asn His Glu Tyr Met Ser Trp Tyr
  85                  90                  95                 100

 cga caa gac cca ggc atg ggg ctg agg ctg att cat tac tca gtt ggt      390
 Arg Gln Asp Pro Gly Met Gly Leu Arg Leu Ile His Tyr Ser Val Gly
                 105                 110                 115

 gct ggt atc act gac caa gga gaa gtc ccc aat ggc tac aat gtc tcc      438
 Ala Gly Ile Thr Asp Gln Gly Glu Val Pro Asn Gly Tyr Asn Val Ser
             120                 125                 130

 aga tca acc aca gag gat ttc ccg ctc agg ctg ctg tcg gct gct ccc      486
 Arg Ser Thr Thr Glu Asp Phe Pro Leu Arg Leu Leu Ser Ala Ala Pro
         135                 140                 145

 tcc cag aca tct gtg tac ttc tgt gcc agc agt ttc ccc cgg cag ccg      534
 Ser Gln Thr Ser Val Tyr Phe Cys Ala Ser Ser Phe Pro Arg Gln Pro
     150                 155                 160

 tcc tac aat gag cag ttc ttc ggg cca ggg aca cgg ctc acc gtg cta      582
 Ser Tyr Asn Glu Gln Phe Phe Gly Pro Gly Thr Arg Leu Thr Val Leu
 165                 170                 175                 180

 gag gac ctg aaa aac gtg ttc cca ccc gag gtc gct gtg ttt gag cca      630
 Glu Asp Leu Lys Asn Val Phe Pro Pro Glu Val Ala Val Phe Glu Pro
                 185                 190                 195

 tca gaa gca gag atc tcc cac acc caa aag gcc aca ctg gtg tgc ctg      678
 Ser Glu Ala Glu Ile Ser His Thr Gln Lys Ala Thr Leu Val Cys Leu
             200                 205                 210

 gcc aca ggt ttc tac ccc gac cac gtg gag ctg agc tgg tgg gtg aat      726
 Ala Thr Gly Phe Tyr Pro Asp His Val Glu Leu Ser Trp Trp Val Asn
         215                 220                 225

 ggg aag gag gtg cac agt ggg gtc agc aca gac ccg cag ccc ctc aag      774
 Gly Lys Glu Val His Ser Gly Val Ser Thr Asp Pro Gln Pro Leu Lys
     230                 235                 240

 gag cag ccc gcc ctc aat gac tcc aga tac tgc ctg agc agc cgc ctg      822
 Glu Gln Pro Ala Leu Asn Asp Ser Arg Tyr Cys Leu Ser Ser Arg Leu
 245                 250                 255                 260

 agg gtc tcg gcc acc ttc tgg cag aac ccc cgc aac cac ttc cgc tgt      870
 Arg Val Ser Ala Thr Phe Trp Gln Asn Pro Arg Asn His Phe Arg Cys
                 265                 270                 275

 caa gtc cag ttc tac ggg ctc tcg gag aat gac gag tgg acc cag gat      918
 Gln Val Gln Phe Tyr Gly Leu Ser Glu Asn Asp Glu Trp Thr Gln Asp
             280                 285                 290

 agg gcc aaa cct gtc acc cag atc gtc agc gcc gag gcc tgg ggt aga      966
 Arg Ala Lys Pro Val Thr Gln Ile Val Ser Ala Glu Ala Trp Gly Arg
         295                 300                 305

 gca gac tgt ggc ttc acc tcc gag tct tac cag caa ggg gtc ctg tct     1014
 Ala Asp Cys Gly Phe Thr Ser Glu Ser Tyr Gln Gln Gly Val Leu Ser
     310                 315                 320

 gcc acc atc ctc tat gag atc ttg cta ggg aag gcc acc ttg tat gct     1062
 Ala Thr Ile Leu Tyr Glu Ile Leu Leu Gly Lys Ala Thr Leu Tyr Ala
 325                 330                 335                 340

 gtg ctg gtc agt gcc ctc gtg ctg atg gcc atg gtc aag aga aag gat     1110
 Val Leu Val Ser Ala Leu Val Leu Met Ala Met Val Lys Arg Lys Asp
                 345                 350                 355

 tcc aga ggc tga                                                     1122
 Ser Arg Gly 






      <210> 433
      <211> 4381
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (377)..(4381)

      <400> 433
 ggagggggga gttcctggtg actggccgcc ggcccttggt gggtggtagg gggtgctggg     60

 gaggagggcg agctcggcgg tgacgcgcgg tcctcacgtg acccggagct gcagagctac    120

 gcagccttcg ttgcagtcgt cactcgcatc tggctaccag ctccccgctg ccctgcgctc    180

 ggcgggctgg catcgggccc ggggaaagcg gagcagtagt tcggtgtagc actgtttgcg    240

 gcgaggagaa aggaaggaga ggagaaaact gcactggatc aaggaggtct tcccataggc    300

 ctgcagtagg gctgtttacc attggaagca agggaaagag gaggagatca atctagaagc    360

 atggagatct gcctgc    atg tct gct gca ggg ctt aag atc act gga agc     409
                      Met Ser Ala Ala Gly Leu Lys Ile Thr Gly Ser
                        1               5                  10

 aaa gaa aca aag agg aga ttg ctc ctg atc agt ata gac tgg gtg tat      457
 Lys Glu Thr Lys Arg Arg Leu Leu Leu Ile Ser Ile Asp Trp Val Tyr
              15                  20                  25

 tgc caa gag aag caa gag gag agg agg gaa ctg cct cgg atc att aca      505
 Cys Gln Glu Lys Gln Glu Glu Arg Arg Glu Leu Pro Arg Ile Ile Thr
          30                  35                  40

 ggt cca cct cca gag gca gct gta gtg gcc ttt gag tgg ctg aag acc      553
 Gly Pro Pro Pro Glu Ala Ala Val Val Ala Phe Glu Trp Leu Lys Thr
      45                  50                  55

 agc acc ctc aca ggc cta cac cca caa cta cca ctc tct tta ccc cag      601
 Ser Thr Leu Thr Gly Leu His Pro Gln Leu Pro Leu Ser Leu Pro Gln
  60                  65                  70                  75

 ccc gag tgc gct cta cca tac ctt gtt cgt gct ttt agc agg ggt gat      649
 Pro Glu Cys Ala Leu Pro Tyr Leu Val Arg Ala Phe Ser Arg Gly Asp
                  80                  85                  90

 tac atg ggc cgc att cag gaa gtg ggc tgg gtg act gca gga ctg gtg      697
 Tyr Met Gly Arg Ile Gln Glu Val Gly Trp Val Thr Ala Gly Leu Val
              95                 100                 105

 atc tgg gct ggc acc tgc tac tac att tac aaa ttt acc aag gga aga      745
 Ile Trp Ala Gly Thr Cys Tyr Tyr Ile Tyr Lys Phe Thr Lys Gly Arg
         110                 115                 120

 gcc cag agt gtg agg act ctt gcc aga aat gga tcc aca gtt aag atg      793
 Ala Gln Ser Val Arg Thr Leu Ala Arg Asn Gly Ser Thr Val Lys Met
     125                 130                 135

 gag act gtg gtt ggg gta cag agc cag acc ttg gcc ata aat gaa gca      841
 Glu Thr Val Val Gly Val Gln Ser Gln Thr Leu Ala Ile Asn Glu Ala
 140                 145                 150                 155

 gag att aag act aaa ccc caa gtc gag att gga gca gaa act gga gca      889
 Glu Ile Lys Thr Lys Pro Gln Val Glu Ile Gly Ala Glu Thr Gly Ala
                 160                 165                 170

 aga agt ggg cct ggg gct gaa gta gag acc aag gcc act gct ata gcc      937
 Arg Ser Gly Pro Gly Ala Glu Val Glu Thr Lys Ala Thr Ala Ile Ala
             175                 180                 185

 ata cac aga gcc aac tct cag gcc aag gca atg gtt ggg gca gag cca      985
 Ile His Arg Ala Asn Ser Gln Ala Lys Ala Met Val Gly Ala Glu Pro
         190                 195                 200

 gag act caa tct gag tcc aaa gtg gtg gct gga aca ctg gtc atg aca     1033
 Glu Thr Gln Ser Glu Ser Lys Val Val Ala Gly Thr Leu Val Met Thr
     205                 210                 215

 gag gca gtg act ctg act gag gtc aag gcc aaa gcc agg gaa gtg gcc     1081
 Glu Ala Val Thr Leu Thr Glu Val Lys Ala Lys Ala Arg Glu Val Ala
 220                 225                 230                 235

 atg aaa gaa gca gtg acc caa act gat gct gag gct ggc aaa ata gtt     1129
 Met Lys Glu Ala Val Thr Gln Thr Asp Ala Glu Ala Gly Lys Ile Val
                 240                 245                 250

 aag aaa gaa gca gtg aca cag acc aag gct aaa gct tgg gcg ctg gtt     1177
 Lys Lys Glu Ala Val Thr Gln Thr Lys Ala Lys Ala Trp Ala Leu Val
             255                 260                 265

 gcc aag aca gag gcc aag aga gaa gca atg acc cag acc aaa gct gaa     1225
 Ala Lys Thr Glu Ala Lys Arg Glu Ala Met Thr Gln Thr Lys Ala Glu
         270                 275                 280

 act cat ata ttg gct gaa aaa gag aca gag att aac aga gta atg gtt     1273
 Thr His Ile Leu Ala Glu Lys Glu Thr Glu Ile Asn Arg Val Met Val
     285                 290                 295

 aca cag agt gag acc ttg gca gta ccc agg gaa gtg gcc aag atg ggg     1321
 Thr Gln Ser Glu Thr Leu Ala Val Pro Arg Glu Val Ala Lys Met Gly
 300                 305                 310                 315

 gcc acg aac aag act gga att gtg gat gaa acc aag aca aga gct ctg     1369
 Ala Thr Asn Lys Thr Gly Ile Val Asp Glu Thr Lys Thr Arg Ala Leu
                 320                 325                 330

 gaa gag act gtg agt gtg gct aag act cag tct gag gcc agg cct ggt     1417
 Glu Glu Thr Val Ser Val Ala Lys Thr Gln Ser Glu Ala Arg Pro Gly
             335                 340                 345

 gcc aca gtt gat gct agg gga aat ccc aat ggc atg tcc agg gag gtg     1465
 Ala Thr Val Asp Ala Arg Gly Asn Pro Asn Gly Met Ser Arg Glu Val
         350                 355                 360

 gct gga gtg gac atg aag tcc tgt gca cag tct cag gct gtg acc aag     1513
 Ala Gly Val Asp Met Lys Ser Cys Ala Gln Ser Gln Ala Val Thr Lys
     365                 370                 375

 atc cag ggt gat gac atg cct ggt act ggg gtt gag gac atg ggg aat     1561
 Ile Gln Gly Asp Asp Met Pro Gly Thr Gly Val Glu Asp Met Gly Asn
 380                 385                 390                 395

 tgt aaa acc atg tct agg gca gag tct ggg gca gac acg agg gct tct     1609
 Cys Lys Thr Met Ser Arg Ala Glu Ser Gly Ala Asp Thr Arg Ala Ser
                 400                 405                 410

 gct cag cct caa att ttt gcc aaa acc cag act gag gcc att cct ggg     1657
 Ala Gln Pro Gln Ile Phe Ala Lys Thr Gln Thr Glu Ala Ile Pro Gly
             415                 420                 425

 gca aag att gat gcc ggg ggt aac acc aat gcc atg tgt aag gtg ggg     1705
 Ala Lys Ile Asp Ala Gly Gly Asn Thr Asn Ala Met Cys Lys Val Gly
         430                 435                 440

 gca ggg gca gat gtg aga gct tgt ata caa cct cag act gtg gcc aag     1753
 Ala Gly Ala Asp Val Arg Ala Cys Ile Gln Pro Gln Thr Val Ala Lys
     445                 450                 455

 aaa cag gct gag gtg acg tct ggt gcc agg gtt gat ggt agg gga aat     1801
 Lys Gln Ala Glu Val Thr Ser Gly Ala Arg Val Asp Gly Arg Gly Asn
 460                 465                 470                 475

 acc aat gtc ata tct aag gca ata act gga gct gac atg aga gct gct     1849
 Thr Asn Val Ile Ser Lys Ala Ile Thr Gly Ala Asp Met Arg Ala Ala
                 480                 485                 490

 gct cag cct caa gct gtt gcc agt act cac gct gag gcc atg tct gat     1897
 Ala Gln Pro Gln Ala Val Ala Ser Thr His Ala Glu Ala Met Ser Asp
             495                 500                 505

 gct aag gtt aag aac aga ggc aat ccc aat gcc atg act aaa gca ggg     1945
 Ala Lys Val Lys Asn Arg Gly Asn Pro Asn Ala Met Thr Lys Ala Gly
         510                 515                 520

 gcc aag gca aac ttg agg gcc aat tcc cag gtt gag gcc ttg cct gat     1993
 Ala Lys Ala Asn Leu Arg Ala Asn Ser Gln Val Glu Ala Leu Pro Asp
     525                 530                 535

 gcc agg gat aag agc aga ggc aat ccc aat gtt atg gct aag gtg ggg     2041
 Ala Arg Asp Lys Ser Arg Gly Asn Pro Asn Val Met Ala Lys Val Gly
 540                 545                 550                 555

 gat ggg aca gac atg ttg tcc tgt aca cag cct cag ctt gtg gcc agt     2089
 Asp Gly Thr Asp Met Leu Ser Cys Thr Gln Pro Gln Leu Val Ala Ser
                 560                 565                 570

 gtt cag gct gat acc ttg tct gat ggc aaa att aag gtc agg ggc aat     2137
 Val Gln Ala Asp Thr Leu Ser Asp Gly Lys Ile Lys Val Arg Gly Asn
             575                 580                 585

 gtc aat acc atg cct aag gaa gga gct ggg gtg gat atg aag gct caa     2185
 Val Asn Thr Met Pro Lys Glu Gly Ala Gly Val Asp Met Lys Ala Gln
         590                 595                 600

 ggt atg gcc cag agc cag ggt gaa gcc tta cct aat act aga ggt aag     2233
 Gly Met Ala Gln Ser Gln Gly Glu Ala Leu Pro Asn Thr Arg Gly Lys
     605                 610                 615

 gct agg ggc aaa gcc aaa gcc aag tgt aag aca ggg cct ggg atg gac     2281
 Ala Arg Gly Lys Ala Lys Ala Lys Cys Lys Thr Gly Pro Gly Met Asp
 620                 625                 630                 635

 atg aaa acc tgt aca caa cct cag gct ggg gtc aag acc cca gct gag     2329
 Met Lys Thr Cys Thr Gln Pro Gln Ala Gly Val Lys Thr Pro Ala Glu
                 640                 645                 650

 gcc ttg ctt gat tcc agg gtt gat ggt agg ggc aat cct aat gcc act     2377
 Ala Leu Leu Asp Ser Arg Val Asp Gly Arg Gly Asn Pro Asn Ala Thr
             655                 660                 665

 tct aaa gcc ggg act aag gca gac cag agg gtc tgt ggt cag ccc ctg     2425
 Ser Lys Ala Gly Thr Lys Ala Asp Gln Arg Val Cys Gly Gln Pro Leu
         670                 675                 680

 gtt gtg gcc aat ccc cag ggt gag gcc ttg cct ggt gcc aag aat aaa     2473
 Val Val Ala Asn Pro Gln Gly Glu Ala Leu Pro Gly Ala Lys Asn Lys
     685                 690                 695

 gtc aag ggc aat ccc cat act gtg ctt aag gtg ggg gct gga gaa ggt     2521
 Val Lys Gly Asn Pro His Thr Val Leu Lys Val Gly Ala Gly Glu Gly
 700                 705                 710                 715

 aca aca gac tct gcc cag cct gag gca gtg gtc agt ttc cag ggt gag     2569
 Thr Thr Asp Ser Ala Gln Pro Glu Ala Val Val Ser Phe Gln Gly Glu
                 720                 725                 730

 gcc ttg ctt ggc acc aag aat aaa gtt aag ggt aat ccc aat gtt gtg     2617
 Ala Leu Leu Gly Thr Lys Asn Lys Val Lys Gly Asn Pro Asn Val Val
             735                 740                 745

 ctt aag gca gaa gtt ggg gaa ggt gca atg ggc act gcc cag ctt cag     2665
 Leu Lys Ala Glu Val Gly Glu Gly Ala Met Gly Thr Ala Gln Leu Gln
         750                 755                 760

 att atg gcc agt tcc aag ggt gag gcc ttg ctt gat tct aag aat aag     2713
 Ile Met Ala Ser Ser Lys Gly Glu Ala Leu Leu Asp Ser Lys Asn Lys
     765                 770                 775

 gtc aag ggt aat tcc aat gct gtg tct aag gca ggg gct ggg aca gat     2761
 Val Lys Gly Asn Ser Asn Ala Val Ser Lys Ala Gly Ala Gly Thr Asp
 780                 785                 790                 795

 aca aca ggc tct gtc cag ccc cag att gtg gcc aat tcc cag ggt gag     2809
 Thr Thr Gly Ser Val Gln Pro Gln Ile Val Ala Asn Ser Gln Gly Glu
                 800                 805                 810

 gtc ttg cct ggt gcc aag aat aag atc aga ggc aat ccc act act gtg     2857
 Val Leu Pro Gly Ala Lys Asn Lys Ile Arg Gly Asn Pro Thr Thr Val
             815                 820                 825

 cct aat tca ggg gtt ggg cca tat aca aca gac tct gcc cgg ctc cag     2905
 Pro Asn Ser Gly Val Gly Pro Tyr Thr Thr Asp Ser Ala Arg Leu Gln
         830                 835                 840

 gct gtg gcc aat tct cag ggt gag gtc ttg cct ggt gcc aaa aat aag     2953
 Ala Val Ala Asn Ser Gln Gly Glu Val Leu Pro Gly Ala Lys Asn Lys
     845                 850                 855

 gtc aag gcc aat ctt aat gct gtg tct aag gca gaa gct ggg atg ggt     3001
 Val Lys Ala Asn Leu Asn Ala Val Ser Lys Ala Glu Ala Gly Met Gly
 860                 865                 870                 875

 gca aca ggc tct gtc cag ccc cag gct gtg gct aat tcc cat tgt gag     3049
 Ala Thr Gly Ser Val Gln Pro Gln Ala Val Ala Asn Ser His Cys Glu
                 880                 885                 890

 acc ttg cct ggt gcc aag aat aag gtc agg gga aat tgg aat gct gtg     3097
 Thr Leu Pro Gly Ala Lys Asn Lys Val Arg Gly Asn Trp Asn Ala Val
             895                 900                 905

 tct aag gca ggg gct ggg atg gat aca agg ggc tct gcc cag ccc cag     3145
 Ser Lys Ala Gly Ala Gly Met Asp Thr Arg Gly Ser Ala Gln Pro Gln
         910                 915                 920

 gct gtg gcc aat tcc cag ggt gaa gtc ttg cct ggt gcc aag aat aag     3193
 Ala Val Ala Asn Ser Gln Gly Glu Val Leu Pro Gly Ala Lys Asn Lys
     925                 930                 935

 gtc aag ggc aat ccc aat gtc gtg tct aag gca ggg gcc aga gaa gat     3241
 Val Lys Gly Asn Pro Asn Val Val Ser Lys Ala Gly Ala Arg Glu Asp
 940                 945                 950                 955

 aca gtg ggc tct acc cag cct cag gtt ttg gcc agc tcc cag cgt gag     3289
 Thr Val Gly Ser Thr Gln Pro Gln Val Leu Ala Ser Ser Gln Arg Glu
                 960                 965                 970

 acc ttg cct ggt gcc agg aat aag gtc aag ggc aat tcc aat gtt gtg     3337
 Thr Leu Pro Gly Ala Arg Asn Lys Val Lys Gly Asn Ser Asn Val Val
             975                 980                 985

 tct aag gca ggg gcc aga gaa gat aca atg ggc tct gcc cag cct cag     3385
 Ser Lys Ala Gly Ala Arg Glu Asp Thr Met Gly Ser Ala Gln Pro Gln
         990                 995                1000

 gtt gtg gcc aac tcc cag cgt gag acc ttg cct ggt gcc agg aat aag     3433
 Val Val Ala Asn Ser Gln Arg Glu Thr Leu Pro Gly Ala Arg Asn Lys
    1005                1010                1015

 gtc aag ggc aat tcc aat gct att tct aag gca gag gct ggg gca ggc     3481
 Val Lys Gly Asn Ser Asn Ala Ile Ser Lys Ala Glu Ala Gly Ala Gly
1020                1025                1030                1035

 ata atg ggc tct gtc cag gtc cag gtt gtg gcc agt ttt cag ggt gag     3529
 Ile Met Gly Ser Val Gln Val Gln Val Val Ala Ser Phe Gln Gly Glu
                1040                1045                1050

 gtc ttg cct ggg gcc aaa aat aag gtc agg ggc aat tcc aat gct gtg     3577
 Val Leu Pro Gly Ala Lys Asn Lys Val Arg Gly Asn Ser Asn Ala Val
            1055                1060                1065

 cct aag gca gag gct ggg gca gat aca gtg ggc tct gcc cag ccc caa     3625
 Pro Lys Ala Glu Ala Gly Ala Asp Thr Val Gly Ser Ala Gln Pro Gln
        1070                1075                1080

 gct gtc gct aat tcc cag agt gag acc ttg ctt ggt gcc agg aat aag     3673
 Ala Val Ala Asn Ser Gln Ser Glu Thr Leu Leu Gly Ala Arg Asn Lys
    1085                1090                1095

 gtc aag ggc aat acc att gct gtg cct aaa gca ggg act ggg gca ggc     3721
 Val Lys Gly Asn Thr Ile Ala Val Pro Lys Ala Gly Thr Gly Ala Gly
1100                1105                1110                1115

 aca agg cac tct gcc cag cct cag att gtg gcc ggt tcc cag ggt gag     3769
 Thr Arg His Ser Ala Gln Pro Gln Ile Val Ala Gly Ser Gln Gly Glu
                1120                1125                1130

 acc ttg cct ggg gca agg gac aag tct atg tcc act tct gag gca gaa     3817
 Thr Leu Pro Gly Ala Arg Asp Lys Ser Met Ser Thr Ser Glu Ala Glu
            1135                1140                1145

 gcc aca gca gaa gat gag gcc tat gca aag cct gag gct gag gcc atg     3865
 Ala Thr Ala Glu Asp Glu Ala Tyr Ala Lys Pro Glu Ala Glu Ala Met
        1150                1155                1160

 ccc act tct gag agt gag ggt ggg tca ggc act caa gcc tgc aga aag     3913
 Pro Thr Ser Glu Ser Glu Gly Gly Ser Gly Thr Gln Ala Cys Arg Lys
    1165                1170                1175

 act cag cct aac atc cat gac tac tac tgg aat ggg att ggt gtt gaa     3961
 Thr Gln Pro Asn Ile His Asp Tyr Tyr Trp Asn Gly Ile Gly Val Glu
1180                1185                1190                1195

 gac tgg att gct gct gag cgg tgg atc aaa ttt agg ttt cag acc atg     4009
 Asp Trp Ile Ala Ala Glu Arg Trp Ile Lys Phe Arg Phe Gln Thr Met
                1200                1205                1210

 gat gga gac tgg gaa aat agc gtg tcc tgg gct gat gat gag aat gaa     4057
 Asp Gly Asp Trp Glu Asn Ser Val Ser Trp Ala Asp Asp Glu Asn Glu
            1215                1220                1225

 gcc agt att ggg tcc tgg agt ggg gct agt gat aag gct ggg att att     4105
 Ala Ser Ile Gly Ser Trp Ser Gly Ala Ser Asp Lys Ala Gly Ile Ile
        1230                1235                1240

 cgg tct tgg gct gtg gct tgt gat gag acc agt gtt aag tcc tgg gct     4153
 Arg Ser Trp Ala Val Ala Cys Asp Glu Thr Ser Val Lys Ser Trp Ala
    1245                1250                1255

 ggg gcc agg gct gag aat gtg gtt ggc atg aga agc cca aag tgg cct     4201
 Gly Ala Arg Ala Glu Asn Val Val Gly Met Arg Ser Pro Lys Trp Pro
1260                1265                1270                1275

 ggt ggc agt ctt aac ttc aat gga atc att gtt gag ttt cct act gga     4249
 Gly Gly Ser Leu Asn Phe Asn Gly Ile Ile Val Glu Phe Pro Thr Gly
                1280                1285                1290

 agc att tct ccc ttt gaa act aag atc ttc aga cca gca gag cat aag     4297
 Ser Ile Ser Pro Phe Glu Thr Lys Ile Phe Arg Pro Ala Glu His Lys
            1295                1300                1305

 atc atg gag gca gga agc aaa aat ttt ggt agt gaa aca cta ggg gtg     4345
 Ile Met Glu Ala Gly Ser Lys Asn Phe Gly Ser Glu Thr Leu Gly Val
        1310                1315                1320

 ata gag agt gat gcc act ccc att tcc acc cct tga                     4381
 Ile Glu Ser Asp Ala Thr Pro Ile Ser Thr Pro 
    1325                1330





      <210> 434
      <211> 338
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (44)..(325)

      <400> 434
 gttttccact gctgtggaaa cctccttgct actatagcgt ctt  atg tat ggt tta      55
                                                  Met Tyr Gly Leu
                                                    1

 aag gaa att tat cag gtg aga gag atg agc aac gtt gtc ttt tct ctc      103
 Lys Glu Ile Tyr Gln Val Arg Glu Met Ser Asn Val Val Phe Ser Leu
   5                  10                  15                  20

 aaa gct gta atg tgg gtt ttg ttt tac tgt tta ttt gtt tgt tgt tgt      151
 Lys Ala Val Met Trp Val Leu Phe Tyr Cys Leu Phe Val Cys Cys Cys
                  25                  30                  35

 atc ctt ttc tcc ttg tta ttt gcc ctt cag aat gca ctt ggg aaa ggc      199
 Ile Leu Phe Ser Leu Leu Phe Ala Leu Gln Asn Ala Leu Gly Lys Gly
              40                  45                  50

 tgg ttc ctt agc ctc ctg gtt tgt gtc ttt ttt ttt ttt ttt tta aac      247
 Trp Phe Leu Ser Leu Leu Val Cys Val Phe Phe Phe Phe Phe Leu Asn
          55                  60                  65

 cca aaa tca ctt tgc aat tgg ttt gaa cct ccc act ggt gca ggg cct      295
 Pro Lys Ser Leu Cys Asn Trp Phe Glu Pro Pro Thr Gly Ala Gly Pro
      70                  75                  80

 tac cgc cct tac cct tta cct ttt ctc taa gtcccaaaac cgg               338
 Tyr Arg Pro Tyr Pro Leu Pro Phe Leu 
  85                  90





      <210> 435
      <211> 724
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (206)..(724)

      <400> 435
 gcggctggag ctgccgccgc cgccgccgcc gcgccagcag gtcctaatgc ctgtcacttc     60

 ccaggacgct ggcagcagca gcagcccgga gcccccgagc cctcggcagg tttgcgtgtc    120

 cttccccgcg atctgattgg ataaagtggg ggctcgacgg tggccgacgt gggacagtct    180

 ggctgtggca ggggtctcgg aaacc  atg ggt tat tgc agt ggc agg tgc acg     232
                              Met Gly Tyr Cys Ser Gly Arg Cys Thr
                                1               5

 ctt atc ttt atc tgt ggc atg caa ctg gtt tgt gtg ctg gag agg caa      280
 Leu Ile Phe Ile Cys Gly Met Gln Leu Val Cys Val Leu Glu Arg Gln
  10                  15                  20                  25

 ata ttt gac ttc ctt gga tat cag tgg gca cct atc ctg gca aat ttt      328
 Ile Phe Asp Phe Leu Gly Tyr Gln Trp Ala Pro Ile Leu Ala Asn Phe
                  30                  35                  40

 gta cat att att atc gtc att ctt ggt ttg ttt gga act att caa tat      376
 Val His Ile Ile Ile Val Ile Leu Gly Leu Phe Gly Thr Ile Gln Tyr
              45                  50                  55

 aga cct cgt tac ata aca gga tat gct gtc tgg cta gtc ctc tgg gtt      424
 Arg Pro Arg Tyr Ile Thr Gly Tyr Ala Val Trp Leu Val Leu Trp Val
          60                  65                  70

 acg tgg aat gtg ttt gtt atc tgc ttc tat ttg gag gct ggg gac ctc      472
 Thr Trp Asn Val Phe Val Ile Cys Phe Tyr Leu Glu Ala Gly Asp Leu
      75                  80                  85

 tca aag gaa aca gac ctt atc ctg act ttt aat ata tca atg cac cga      520
 Ser Lys Glu Thr Asp Leu Ile Leu Thr Phe Asn Ile Ser Met His Arg
  90                  95                 100                 105

 tct tgg tgg atg gag aat gga cca gga tgt acg gtg acg tca gtg aca      568
 Ser Trp Trp Met Glu Asn Gly Pro Gly Cys Thr Val Thr Ser Val Thr
                 110                 115                 120

 cct gcc cca gac tgg gcc cca gaa gac cat cgc tac atc acg gtc tca      616
 Pro Ala Pro Asp Trp Ala Pro Glu Asp His Arg Tyr Ile Thr Val Ser
             125                 130                 135

 ggg tgt ttg ctg gag tac cag tac ata gaa gtg gct cat agt tcc ctc      664
 Gly Cys Leu Leu Glu Tyr Gln Tyr Ile Glu Val Ala His Ser Ser Leu
         140                 145                 150

 cag att gtc ctc gca ggg tgt act act ttt gca atg ttg act gtg gaa      712
 Gln Ile Val Leu Ala Gly Cys Thr Thr Phe Ala Met Leu Thr Val Glu
     155                 160                 165

 cac cag agt tag                                                      724
 His Gln Ser 
 170





      <210> 436
      <211> 1772
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (56)..(1489)

      <400> 436
 gacgatttcg tggaacagac gttccctggc ggccctggcg ccttcaaacc cagac atg      58
                                                              Met
                                                                1

 ctg ctg ctg ctg ctg ctg ctg ccc ctg ctc tgg ggg aca aag ggg atg      106
 Leu Leu Leu Leu Leu Leu Leu Pro Leu Leu Trp Gly Thr Lys Gly Met
               5                  10                  15

 gag gga gac aga caa tat ggg gat ggt tac ttg ctg caa gtg cag gag      154
 Glu Gly Asp Arg Gln Tyr Gly Asp Gly Tyr Leu Leu Gln Val Gln Glu
          20                  25                  30

 ctg gtg acg gtg cag gag ggc ctg tgt gtc cat gtg ccc tgc tcc ttc      202
 Leu Val Thr Val Gln Glu Gly Leu Cys Val His Val Pro Cys Ser Phe
      35                  40                  45

 tcc tac ccc cag gat ggc tgg act gac tct gac cca gtt cat ggc tac      250
 Ser Tyr Pro Gln Asp Gly Trp Thr Asp Ser Asp Pro Val His Gly Tyr
  50                  55                  60                  65

 tgg ttc cgg gca gga gac aga cca tac caa gac gct cca gtg gcc aca      298
 Trp Phe Arg Ala Gly Asp Arg Pro Tyr Gln Asp Ala Pro Val Ala Thr
                  70                  75                  80

 aac aac cca gac aga gaa gtg cag gca gag acc cag ggc cga ttc caa      346
 Asn Asn Pro Asp Arg Glu Val Gln Ala Glu Thr Gln Gly Arg Phe Gln
              85                  90                  95

 ctc ctt ggg gac att tgg agc aac gac tgc tcc ctg agc atc aga gac      394
 Leu Leu Gly Asp Ile Trp Ser Asn Asp Cys Ser Leu Ser Ile Arg Asp
         100                 105                 110

 gcc agg aag agg gat aag ggg tca tat ttc ttt cgg cta gag aga gga      442
 Ala Arg Lys Arg Asp Lys Gly Ser Tyr Phe Phe Arg Leu Glu Arg Gly
     115                 120                 125

 agc atg aaa tgg agt tac aaa tca cag ttg aat tac aaa act aag cag      490
 Ser Met Lys Trp Ser Tyr Lys Ser Gln Leu Asn Tyr Lys Thr Lys Gln
 130                 135                 140                 145

 ctg tct gtg ttt gtg aca gcc ctg acc cat agg cct gac atc ctc atc      538
 Leu Ser Val Phe Val Thr Ala Leu Thr His Arg Pro Asp Ile Leu Ile
                 150                 155                 160

 cta ggg acc cta gag tct ggc cac tcc agg aac ctg acc tgc tct gtg      586
 Leu Gly Thr Leu Glu Ser Gly His Ser Arg Asn Leu Thr Cys Ser Val
             165                 170                 175

 ccc tgg gcc tgt aag cag ggg aca ccc ccc atg atc tcc tgg att ggg      634
 Pro Trp Ala Cys Lys Gln Gly Thr Pro Pro Met Ile Ser Trp Ile Gly
         180                 185                 190

 gcc tcc gtg tcc tcc ccg ggc ccc act act gcc cgc tcc tca gtg ctc      682
 Ala Ser Val Ser Ser Pro Gly Pro Thr Thr Ala Arg Ser Ser Val Leu
     195                 200                 205

 acc ctt acc cca aag ccc cag gac cac ggc acc agc ctc acc tgt cag      730
 Thr Leu Thr Pro Lys Pro Gln Asp His Gly Thr Ser Leu Thr Cys Gln
 210                 215                 220                 225

 gtg acc ttg cct ggg aca ggt gtg acc acg acc agt acc gtc cgc ctc      778
 Val Thr Leu Pro Gly Thr Gly Val Thr Thr Thr Ser Thr Val Arg Leu
                 230                 235                 240

 gat gtg tcc tat cct cct cag aac ttg acc atg act gtc ttc caa gga      826
 Asp Val Ser Tyr Pro Pro Gln Asn Leu Thr Met Thr Val Phe Gln Gly
             245                 250                 255

 gat ggc aca gca tcc aca acc ttg agg aat ggc tcg gcc ctt tca gtc      874
 Asp Gly Thr Ala Ser Thr Thr Leu Arg Asn Gly Ser Ala Leu Ser Val
         260                 265                 270

 ctg gag ggc cag tcc ctg cac ctt gtc tgt gct gtc gac agc aat ccc      922
 Leu Glu Gly Gln Ser Leu His Leu Val Cys Ala Val Asp Ser Asn Pro
     275                 280                 285

 cct gcc agg ctg agc tgg acc tgg ggg agc ctg acc ctg agc ccc tca      970
 Pro Ala Arg Leu Ser Trp Thr Trp Gly Ser Leu Thr Leu Ser Pro Ser
 290                 295                 300                 305

 cag tcc tcg aac ctt ggg gtg ctg gag ctg cct cga gtg cat gtg aag     1018
 Gln Ser Ser Asn Leu Gly Val Leu Glu Leu Pro Arg Val His Val Lys
                 310                 315                 320

 gat gaa ggg gaa ttc acc tgc cga gct cag aac cct cta ggc tcc cag     1066
 Asp Glu Gly Glu Phe Thr Cys Arg Ala Gln Asn Pro Leu Gly Ser Gln
             325                 330                 335

 cac att tcc ctg agc ctc tcc ctg caa aac gag tac aca ggc aaa atg     1114
 His Ile Ser Leu Ser Leu Ser Leu Gln Asn Glu Tyr Thr Gly Lys Met
         340                 345                 350

 agg cct ata tca gga gtg atg cta ggg gca ttc ggg gga gct gga gcc     1162
 Arg Pro Ile Ser Gly Val Met Leu Gly Ala Phe Gly Gly Ala Gly Ala
     355                 360                 365

 aca gcc ctg gtc ttc ctg tcc ttc tgc atc atc ttc gtt gta gtg agg     1210
 Thr Ala Leu Val Phe Leu Ser Phe Cys Ile Ile Phe Val Val Val Arg
 370                 375                 380                 385

 tcc tgc agg aag aaa tcg gca agg cca gca gtg ggc gtg ggg gat aca     1258
 Ser Cys Arg Lys Lys Ser Ala Arg Pro Ala Val Gly Val Gly Asp Thr
                 390                 395                 400

 ggc atg gag gac gca aac gct gtc agg ggc tca gcc tct cag gga ccc     1306
 Gly Met Glu Asp Ala Asn Ala Val Arg Gly Ser Ala Ser Gln Gly Pro
             405                 410                 415

 ctg att gaa tcc ccg gca gat gac agc ccc cca cac cat gct ccg cca     1354
 Leu Ile Glu Ser Pro Ala Asp Asp Ser Pro Pro His His Ala Pro Pro
         420                 425                 430

 gcc ctg gcc acc ccc tcc cca gag gaa gga gag atc cag tat gca tcc     1402
 Ala Leu Ala Thr Pro Ser Pro Glu Glu Gly Glu Ile Gln Tyr Ala Ser
     435                 440                 445

 ctc agc ttc cac aaa gcg agg cct cag tac cca cag gaa cag gag gcc     1450
 Leu Ser Phe His Lys Ala Arg Pro Gln Tyr Pro Gln Glu Gln Glu Ala
 450                 455                 460                 465

 atc ggc tat gag tac tcc gag atc aac atc ccc aag tga gaaactgcag      1499
 Ile Gly Tyr Glu Tyr Ser Glu Ile Asn Ile Pro Lys 
                 470                 475

 agactcaggc ctgtttgagg gctcacgacc cctgcagcaa agaagcccga gactgattcc   1559

 tttagaatta acagccctcc atgctgtgca acaggacatc agaacttatt cctcttgtca   1619

 aactgaaaat gcgtgcctga tgaccaaact ctccctttct ccatccaatc ggtccacact   1679

 ccccgccccc ggcctctggt acccaccatt ctcttctcta cttctctgag gtcgactatt   1739

 ttaggttcca aatatagtga gatcgtagag tga                                1772




      <210> 437
      <211> 2254
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (95)..(1840)

      <400> 437
 tcgcgagctc gcagccacta gtagcgggcg acagtgcgca ggaattcgtc cttttcccgg     60

 gtcgacgatt tcgatctgcg cctcctatgc ggag    atg cta ctg cca ctg ctg     112
                                          Met Leu Leu Pro Leu Leu
                                            1               5

 ctg tcc tcg ctg ctg ggc ggg tcc cag gct atg gat ggg aga ttc tgg      160
 Leu Ser Ser Leu Leu Gly Gly Ser Gln Ala Met Asp Gly Arg Phe Trp
              10                  15                  20

 ata cga gtg cag gag tca gtg atg gtg ccg gag ggc ctg tgc atc tct      208
 Ile Arg Val Gln Glu Ser Val Met Val Pro Glu Gly Leu Cys Ile Ser
          25                  30                  35

 gtg ccc tac tct ttc tcc tac ccc cga caa gac tgg aca ggg tct acc      256
 Val Pro Tyr Ser Phe Ser Tyr Pro Arg Gln Asp Trp Thr Gly Ser Thr
      40                  45                  50

 cca gct tat ggc tac tgg ttc aaa gca gtg act gag aca acc aag ggt      304
 Pro Ala Tyr Gly Tyr Trp Phe Lys Ala Val Thr Glu Thr Thr Lys Gly
  55                  60                  65                  70

 gct cct gtg gcc aca aac cac cag agt cga gag gtg gaa atg agc acc      352
 Ala Pro Val Ala Thr Asn His Gln Ser Arg Glu Val Glu Met Ser Thr
                  75                  80                  85

 cgg ggc cga ttc cag ctc act ggg gat ccc gcc aag ggg aac tgc tcc      400
 Arg Gly Arg Phe Gln Leu Thr Gly Asp Pro Ala Lys Gly Asn Cys Ser
              90                  95                 100

 ttg gtg atc aga gac gcg cag atg cag gat gag tca cag tac ttc ttt      448
 Leu Val Ile Arg Asp Ala Gln Met Gln Asp Glu Ser Gln Tyr Phe Phe
         105                 110                 115

 cgg gtg gag aga gga agc tat gtg aga tat aat ttc atg aac gat ggg      496
 Arg Val Glu Arg Gly Ser Tyr Val Arg Tyr Asn Phe Met Asn Asp Gly
     120                 125                 130

 ttc ttt cta aaa gta aca gcc ctg act cag aag cct gat gtc tac atc      544
 Phe Phe Leu Lys Val Thr Ala Leu Thr Gln Lys Pro Asp Val Tyr Ile
 135                 140                 145                 150

 ccc gag acc ctg gag ccc ggg cag ccg gtg acg gtc atc tgt gtg ttt      592
 Pro Glu Thr Leu Glu Pro Gly Gln Pro Val Thr Val Ile Cys Val Phe
                 155                 160                 165

 aac tgg gcc ttt gag gaa tgt cca ccc cct tct ttc tcc tgg acg ggg      640
 Asn Trp Ala Phe Glu Glu Cys Pro Pro Pro Ser Phe Ser Trp Thr Gly
             170                 175                 180

 gct gcc ctc tcc tcc caa gga acc aaa cca acg acc tcc cac ttc tca      688
 Ala Ala Leu Ser Ser Gln Gly Thr Lys Pro Thr Thr Ser His Phe Ser
         185                 190                 195

 gtg ctc agc ttc acg ccc aga ccc cag gac cac aac acc gac ctc acc      736
 Val Leu Ser Phe Thr Pro Arg Pro Gln Asp His Asn Thr Asp Leu Thr
     200                 205                 210

 tgc cat gtg gac ttc tcc aga aag ggt gtg agc gta cag agg acc gtc      784
 Cys His Val Asp Phe Ser Arg Lys Gly Val Ser Val Gln Arg Thr Val
 215                 220                 225                 230

 cga ctc cgt gtg gcc tat gcc ccc aga gac ctt gtt atc agc att tca      832
 Arg Leu Arg Val Ala Tyr Ala Pro Arg Asp Leu Val Ile Ser Ile Ser
                 235                 240                 245

 cgt gac aac acg cca gcc ctg gag ccc cag ccc cag gga aat gtc cca      880
 Arg Asp Asn Thr Pro Ala Leu Glu Pro Gln Pro Gln Gly Asn Val Pro
             250                 255                 260

 tac ctg gaa gcc caa aaa ggc cag ttc ctg cgg ctc ctc tgt gct gct      928
 Tyr Leu Glu Ala Gln Lys Gly Gln Phe Leu Arg Leu Leu Cys Ala Ala
         265                 270                 275

 gac agc cag ccc cct gcc aca ctg agc tgg gtc ctg cag aac aga gtc      976
 Asp Ser Gln Pro Pro Ala Thr Leu Ser Trp Val Leu Gln Asn Arg Val
     280                 285                 290

 ctc tcc tcg tcc cat ccc tgg ggc cct aga ccc ctg ggg ctg gag ctg     1024
 Leu Ser Ser Ser His Pro Trp Gly Pro Arg Pro Leu Gly Leu Glu Leu
 295                 300                 305                 310

 ccc ggg gtg aag gct ggg gat tca ggg cgc tac acc tgc cga gcg gag     1072
 Pro Gly Val Lys Ala Gly Asp Ser Gly Arg Tyr Thr Cys Arg Ala Glu
                 315                 320                 325

 aac agg ctt ggc tcc cag cag cga gcc ctg gac ctc tct gtg cag tat     1120
 Asn Arg Leu Gly Ser Gln Gln Arg Ala Leu Asp Leu Ser Val Gln Tyr
             330                 335                 340

 cct cca gag aac ctg aga gtg atg gtt tcc caa gca aac agg aca gtc     1168
 Pro Pro Glu Asn Leu Arg Val Met Val Ser Gln Ala Asn Arg Thr Val
         345                 350                 355

 ctg gaa aac ctt ggg aac ggc acg tct ctc cca gta ctg gag ggc caa     1216
 Leu Glu Asn Leu Gly Asn Gly Thr Ser Leu Pro Val Leu Glu Gly Gln
     360                 365                 370

 agc ctg tgc ctg gtc tgt gtc aca cac agc agc ccc cca gcc agg ctg     1264
 Ser Leu Cys Leu Val Cys Val Thr His Ser Ser Pro Pro Ala Arg Leu
 375                 380                 385                 390

 agc tgg acc cag agg gga cag gtt ctg agc ccc tcc cag ccc tca gac     1312
 Ser Trp Thr Gln Arg Gly Gln Val Leu Ser Pro Ser Gln Pro Ser Asp
                 395                 400                 405

 ccc ggg gtc ctg gag ctg cct cgg gtt caa gtg gag cac gaa gga gag     1360
 Pro Gly Val Leu Glu Leu Pro Arg Val Gln Val Glu His Glu Gly Glu
             410                 415                 420

 ttc acc tgc cac gct cgg cac cca ctg ggc tcc cag cac gtc tct ctc     1408
 Phe Thr Cys His Ala Arg His Pro Leu Gly Ser Gln His Val Ser Leu
         425                 430                 435

 agc ctc tcc gtg cac tat aag aag gga ctc atc tca acg gca ttc tcc     1456
 Ser Leu Ser Val His Tyr Lys Lys Gly Leu Ile Ser Thr Ala Phe Ser
     440                 445                 450

 aac gga gcg ttt ctg gga atc ggc atc acg gct ctt ctt ttc ctc tgc     1504
 Asn Gly Ala Phe Leu Gly Ile Gly Ile Thr Ala Leu Leu Phe Leu Cys
 455                 460                 465                 470

 ctg gcc ctg atc atc atg aag att cta ccg aag aga cgg act cag aca     1552
 Leu Ala Leu Ile Ile Met Lys Ile Leu Pro Lys Arg Arg Thr Gln Thr
                 475                 480                 485

 gaa acc ccg agg ccc agg ttc tcc cgg cac agc acg atc ctg gat tac     1600
 Glu Thr Pro Arg Pro Arg Phe Ser Arg His Ser Thr Ile Leu Asp Tyr
             490                 495                 500

 atc aat gtg gtc ccg acg gct ggc ccc ctg gtg agt gtc tgg gcc atg     1648
 Ile Asn Val Val Pro Thr Ala Gly Pro Leu Val Ser Val Trp Ala Met
         505                 510                 515

 ctt cca ctt ttt ctc ttc tct aaa gct gac atc cca ctt tct gac ttt     1696
 Leu Pro Leu Phe Leu Phe Ser Lys Ala Asp Ile Pro Leu Ser Asp Phe
     520                 525                 530

 tgc acc cct tgt ctt agc gac atc aag gtg gga aaa gca ccg ata gtt     1744
 Cys Thr Pro Cys Leu Ser Asp Ile Lys Val Gly Lys Ala Pro Ile Val
 535                 540                 545                 550

 ctg aat tca aat cct gcc tgg cac tta cta gct atg aga cct cag cca     1792
 Leu Asn Ser Asn Pro Ala Trp His Leu Leu Ala Met Arg Pro Gln Pro
                 555                 560                 565

 cgt cac tca ccc cct ctg agc ctt cat ttc ttc ctc tgt ctc ctt tga     1840
 Arg His Ser Pro Pro Leu Ser Leu His Phe Phe Leu Cys Leu Leu 
             570                 575                 580

 gagttggttt gaggattaga atacatgcac tttctcaatc tgtagccatt gttccattat   1900

 tactgccacc attgacatga ctacacttaa ctgcttaaca attatgtgta tcatcgggag   1960

 gctgggcatc ctagggattc agcacagggg gtctgaaatc agcctgcatg ggttcaaatc   2020

 ctgctgtcat cactgtgtca tgaaacaagt gtcttaactt ctctgtgcct caatttcttt   2080

 agctgtaaca tggagacaat actagcggcc acctccttag atgatgctgg gtgttaaata   2140

 tattgtactt gcataataaa atattcagaa tatcaactgg cccctgggta ataactctgt   2200

 aattctggaa aatattaagt agataacatc ttatgctgat gactgcaaaa atgg         2254




      <210> 438
      <211> 1020
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (1)..(1020)

      <400> 438
  atg agt gga ctc ttg ctg ctc ttt tgg ggg ttc ccg gcc ctg ttc ccc      48
  Met Ser Gly Leu Leu Leu Leu Phe Trp Gly Phe Pro Ala Leu Phe Pro
    1               5                  10                  15

 gag tct ccc tgc tgg ctg ctg gcc aca ggt cag gta gct cga gcc agg       96
 Glu Ser Pro Cys Trp Leu Leu Ala Thr Gly Gln Val Ala Arg Ala Arg
              20                  25                  30

 aag atc ctg tgg cgc ttt gca gaa gcc agt ggc gtg ggc ccc ggg gac      144
 Lys Ile Leu Trp Arg Phe Ala Glu Ala Ser Gly Val Gly Pro Gly Asp
          35                  40                  45

 agt tcc ttg gag gag aac tcc ctg gct aca gag ctg acc atg ctg tct      192
 Ser Ser Leu Glu Glu Asn Ser Leu Ala Thr Glu Leu Thr Met Leu Ser
      50                  55                  60

 gca cgg agc ccc cag ccc cgg tac cac tcc cca ctg ggg ctt ctg cgt      240
 Ala Arg Ser Pro Gln Pro Arg Tyr His Ser Pro Leu Gly Leu Leu Arg
  65                  70                  75                  80

 acc cga gtc acc tgg aga aac ggg ctt atc ttg ggc ttc agc tca tgc      288
 Thr Arg Val Thr Trp Arg Asn Gly Leu Ile Leu Gly Phe Ser Ser Cys
                  85                  90                  95

 tgt ctg cac gga gcc ccc agc ccc ggt acc act ccc cac tgg ggc ttc      336
 Cys Leu His Gly Ala Pro Ser Pro Gly Thr Thr Pro His Trp Gly Phe
             100                 105                 110

 tgc gta ccc gag tca cct gga gaa acg ggc tta tct tgg gct tca gct      384
 Cys Val Pro Glu Ser Pro Gly Glu Thr Gly Leu Ser Trp Ala Ser Ala
         115                 120                 125

 cgg ctg gtt ggt gga ggc atc aga gct agc ttc cgc cgc agc ctg gca      432
 Arg Leu Val Gly Gly Gly Ile Arg Ala Ser Phe Arg Arg Ser Leu Ala
     130                 135                 140

 cct cag gtg ccg acc ttc tac ctg ccc tac ttc ctg gag gcc ggc ctg      480
 Pro Gln Val Pro Thr Phe Tyr Leu Pro Tyr Phe Leu Glu Ala Gly Leu
 145                 150                 155                 160

 gag gcg gca gcc ttg gtc ttc ctg ctc ctg acg gca gat tgc tgt gga      528
 Glu Ala Ala Ala Leu Val Phe Leu Leu Leu Thr Ala Asp Cys Cys Gly
                 165                 170                 175

 cgc cgc ccc gtg ctg ctg ctg ggc acc atg gtc aca ggc ctg gca tcc      576
 Arg Arg Pro Val Leu Leu Leu Gly Thr Met Val Thr Gly Leu Ala Ser
             180                 185                 190

 ctg ctg ctc ctc gct ggg gcc cag tat ctg cca ggc tgg act gtg ctg      624
 Leu Leu Leu Leu Ala Gly Ala Gln Tyr Leu Pro Gly Trp Thr Val Leu
         195                 200                 205

 ttc ctc tct gtc ctg ggg ctc ctg gcc tcc cgg gct gtg tcc gca ctc      672
 Phe Leu Ser Val Leu Gly Leu Leu Ala Ser Arg Ala Val Ser Ala Leu
     210                 215                 220

 agc agc ctc ttc gcg gcc gag gtc ttc ccc acg gtg atc agg ggg gcc      720
 Ser Ser Leu Phe Ala Ala Glu Val Phe Pro Thr Val Ile Arg Gly Ala
 225                 230                 235                 240

 ggg ctg ggc ctg gtg ctg ggg gcc ggg ttc ctg ggc cag gca gcc ggc      768
 Gly Leu Gly Leu Val Leu Gly Ala Gly Phe Leu Gly Gln Ala Ala Gly
                 245                 250                 255

 ccc ctg gac acc ctg cac ggc cgg cag ggc ttc ttc ctg caa caa gtc      816
 Pro Leu Asp Thr Leu His Gly Arg Gln Gly Phe Phe Leu Gln Gln Val
             260                 265                 270

 gtc ttc gcc tcc ctt gct gtc ctt gcc ctg ctg tgt gtc ctg ctg ctg      864
 Val Phe Ala Ser Leu Ala Val Leu Ala Leu Leu Cys Val Leu Leu Leu
         275                 280                 285

 cct gag agc cga agc cgg ggg ctg ccc cag tca ctg cag gac gcc gac      912
 Pro Glu Ser Arg Ser Arg Gly Leu Pro Gln Ser Leu Gln Asp Ala Asp
     290                 295                 300

 cgc ctg cgc cgc tcc cca ctc ctg cgg ggc cgc ccc cgc cag gac cac      960
 Arg Leu Arg Arg Ser Pro Leu Leu Arg Gly Arg Pro Arg Gln Asp His
 305                 310                 315                 320

 ctg cct ctg ctg ccg ccc tcc aac tcc tac tgg gcc ggc cac acc ccc     1008
 Leu Pro Leu Leu Pro Pro Ser Asn Ser Tyr Trp Ala Gly His Thr Pro
                 325                 330                 335

 gag cag cac tag                                                     1020
 Glu Gln His 






      <210> 439
      <211> 2076
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (1)..(2028)

      <400> 439
  atg ggc ttt att tgc ata acg agg cca cgt ttt tcc agc caa gcc aca      48
  Met Gly Phe Ile Cys Ile Thr Arg Pro Arg Phe Ser Ser Gln Ala Thr
    1               5                  10                  15

 ctc gaa gag ttc tac tcc tcg gtc acc ctc cgc aat gta ctt atc ccc       96
 Leu Glu Glu Phe Tyr Ser Ser Val Thr Leu Arg Asn Val Leu Ile Pro
              20                  25                  30

 aca gcc ctc gga gag cta cag tcc agc ctg gga cgg cct ccc aat gct      144
 Thr Ala Leu Gly Glu Leu Gln Ser Ser Leu Gly Arg Pro Pro Asn Ala
          35                  40                  45

 ctg ttc cag tgt gcg gag gct cag gga ttc tca gtg gca cca aga tac      192
 Leu Phe Gln Cys Ala Glu Ala Gln Gly Phe Ser Val Ala Pro Arg Tyr
      50                  55                  60

 cca gcc ctc gag gag aac ctc agc cgc gcc ccg ccc ctc tgg cgg gac      240
 Pro Ala Leu Glu Glu Asn Leu Ser Arg Ala Pro Pro Leu Trp Arg Asp
  65                  70                  75                  80

 cgg cca cca tcc tct cgc gag agc atc ccg tgc gac cgg aag tgg ggc      288
 Arg Pro Pro Ser Ser Arg Glu Ser Ile Pro Cys Asp Arg Lys Trp Gly
                  85                  90                  95

 ggc gac ccc gga agt ccc cgc cgg gtg cag ctt ggt cgg ttc gat cgc      336
 Gly Asp Pro Gly Ser Pro Arg Arg Val Gln Leu Gly Arg Phe Asp Arg
             100                 105                 110

 cgc cgg gac ctg aca ccg ccc gga gtt ggc gtc cct tct ccc tct ccg      384
 Arg Arg Asp Leu Thr Pro Pro Gly Val Gly Val Pro Ser Pro Ser Pro
         115                 120                 125

 agt gct gct cct gtc att gtg gcc atg gac ggc ccc cga ccc cca acc      432
 Ser Ala Ala Pro Val Ile Val Ala Met Asp Gly Pro Arg Pro Pro Thr
     130                 135                 140

 cga gat cct tta ccc cgg gcc tcg acc ctc gac ccg gga ccc ctc ccc      480
 Arg Asp Pro Leu Pro Arg Ala Ser Thr Leu Asp Pro Gly Pro Leu Pro
 145                 150                 155                 160

 cca ggc ctc gat ccc cga ccc ccg att cgg gac ccc ttc ccc ggg gcc      528
 Pro Gly Leu Asp Pro Arg Pro Pro Ile Arg Asp Pro Phe Pro Gly Ala
                 165                 170                 175

 tcc atc ccc aaa tct caa ccc ggt tcg gac cag gcc acg ctg tcc gtg      576
 Ser Ile Pro Lys Ser Gln Pro Gly Ser Asp Gln Ala Thr Leu Ser Val
             180                 185                 190

 act gcc ccc cag acc cat cca cag tcg tct ctc aac acg ctt att cag      624
 Thr Ala Pro Gln Thr His Pro Gln Ser Ser Leu Asn Thr Leu Ile Gln
         195                 200                 205

 gaa cta acg cgt gag caa ccg aga cct gaa tgg ctg ctt tct gca cac      672
 Glu Leu Thr Arg Glu Gln Pro Arg Pro Glu Trp Leu Leu Ser Ala His
     210                 215                 220

 aca gca agt ggt cat ggg agt cga gtt ttc aga gaa cac aat gtc ttc      720
 Thr Ala Ser Gly His Gly Ser Arg Val Phe Arg Glu His Asn Val Phe
 225                 230                 235                 240

 aga gat gtg ggt gtg gcc tct ctg gtg ctg tgt ggc ctt cag tgt ggc      768
 Arg Asp Val Gly Val Ala Ser Leu Val Leu Cys Gly Leu Gln Cys Gly
                 245                 250                 255

 ctc tct ggt gct gtg tgg cct tca ctg tgg cct ctc tgg tgc tgt gtg      816
 Leu Ser Gly Ala Val Trp Pro Ser Leu Trp Pro Leu Trp Cys Cys Val
             260                 265                 270

 gcc ttc agt gtg gcc tct ctg gtg ctg tgt ggc ctt cag tgt ggc cgc      864
 Ala Phe Ser Val Ala Ser Leu Val Leu Cys Gly Leu Gln Cys Gly Arg
         275                 280                 285

 tct ggt gct gtg tgg cct tca gtg tgg cct ctc tgg tgc tgt gtg gcc      912
 Ser Gly Ala Val Trp Pro Ser Val Trp Pro Leu Trp Cys Cys Val Ala
     290                 295                 300

 ttc act gtg gcc tct ctg gtg ctg tgt ggc ctt cac tgt ggc ctc tct      960
 Phe Thr Val Ala Ser Leu Val Leu Cys Gly Leu His Cys Gly Leu Ser
 305                 310                 315                 320

 ggt gct gtg tgg cct tca ctg tgg cct ctc tgg tgc tgt gtg gcc ttc     1008
 Gly Ala Val Trp Pro Ser Leu Trp Pro Leu Trp Cys Cys Val Ala Phe
                 325                 330                 335

 act gtg gcc tct ctg gtg ctg tgt ggc ctt cag tgt ggc cgc tct ggt     1056
 Thr Val Ala Ser Leu Val Leu Cys Gly Leu Gln Cys Gly Arg Ser Gly
             340                 345                 350

 gct gtg tgg cct tca gtg tgg ccg ctc tgg tgc tgt gtg gcc ttc agt     1104
 Ala Val Trp Pro Ser Val Trp Pro Leu Trp Cys Cys Val Ala Phe Ser
         355                 360                 365

 gtg gcc tct ctg gtg ctg tgt ggc ctt cag tgt ggc ctc tct ggt gct     1152
 Val Ala Ser Leu Val Leu Cys Gly Leu Gln Cys Gly Leu Ser Gly Ala
     370                 375                 380

 gtg tgg cct tca gtg tgg cct ctc tgg tgc tgt gtg gcc ttc act gtg     1200
 Val Trp Pro Ser Val Trp Pro Leu Trp Cys Cys Val Ala Phe Thr Val
 385                 390                 395                 400

 gcc tct ctg gtg ctg tgt ggc ctt cag tgt ggc cgc tct ggt gct gtg     1248
 Ala Ser Leu Val Leu Cys Gly Leu Gln Cys Gly Arg Ser Gly Ala Val
                 405                 410                 415

 tgg cct tca gtg tgg ccg ctc tgg tgc tgt gtg gcc ttc agt gtg gcc     1296
 Trp Pro Ser Val Trp Pro Leu Trp Cys Cys Val Ala Phe Ser Val Ala
             420                 425                 430

 tct ctg gtg ctg tgt ggc ctt cag tgt ggc cgc tct ggt gct gtg tgg     1344
 Ser Leu Val Leu Cys Gly Leu Gln Cys Gly Arg Ser Gly Ala Val Trp
         435                 440                 445

 cct tca gtg tgg cct ctc tgg tgc tgt gtg gcc ttc agt gtg gcc tct     1392
 Pro Ser Val Trp Pro Leu Trp Cys Cys Val Ala Phe Ser Val Ala Ser
     450                 455                 460

 ctg gtg ctg tgt ggc ctt cag tgt ggc ctc tct ggt gct gtg tgg cct     1440
 Leu Val Leu Cys Gly Leu Gln Cys Gly Leu Ser Gly Ala Val Trp Pro
 465                 470                 475                 480

 tca gtg tgg cct ctc tgg tgc tgt gtg gcc ttc act gtg gcc tct ctg     1488
 Ser Val Trp Pro Leu Trp Cys Cys Val Ala Phe Thr Val Ala Ser Leu
                 485                 490                 495

 gtg ctg tgt ggc ctt cag tgt ggc cgc tct ggt gct gtg tgg cct tca     1536
 Val Leu Cys Gly Leu Gln Cys Gly Arg Ser Gly Ala Val Trp Pro Ser
             500                 505                 510

 gtg tgg ccg ctc tgg tgc tgt gtg gcc ttc agt gtg gcc tct ctg gtg     1584
 Val Trp Pro Leu Trp Cys Cys Val Ala Phe Ser Val Ala Ser Leu Val
         515                 520                 525

 ctg tgt ggc ctt cag tgt ggc tct gac cat tgc ttc tgg agg ctg ctc     1632
 Leu Cys Gly Leu Gln Cys Gly Ser Asp His Cys Phe Trp Arg Leu Leu
     530                 535                 540

 aag gat gga gcc aca gct gtg cat gct cag ccc tgc cga ggt ccc agg     1680
 Lys Asp Gly Ala Thr Ala Val His Ala Gln Pro Cys Arg Gly Pro Arg
 545                 550                 555                 560

 cca ggc ttt gtt gct tcc gtt cat gga agc gca cag gat ggg gcc gac     1728
 Pro Gly Phe Val Ala Ser Val His Gly Ser Ala Gln Asp Gly Ala Asp
                 565                 570                 575

 gct gtg ccg gtc gtg ggg aaa tct cac tgg gga aga gaa aag ccc aag     1776
 Ala Val Pro Val Val Gly Lys Ser His Trp Gly Arg Glu Lys Pro Lys
             580                 585                 590

 cct tgt tgg tta cgt cag ccg gtc cat ggc ggt gtc ctg cgg acc cca     1824
 Pro Cys Trp Leu Arg Gln Pro Val His Gly Gly Val Leu Arg Thr Pro
         595                 600                 605

 gag ccc ccg gga agg gcg caa gtc aaa gag cac tgg agg cac cgc cgg     1872
 Glu Pro Pro Gly Arg Ala Gln Val Lys Glu His Trp Arg His Arg Arg
     610                 615                 620

 cga tgg acg tcc agg tcc cgg ctc ctg tgc tgg aaa gcg ttg atg ggg     1920
 Arg Trp Thr Ser Arg Ser Arg Leu Leu Cys Trp Lys Ala Leu Met Gly
 625                 630                 635                 640

 agc gtc ggc gct gac cac acg cgg gag ctg cgg aag ccc agc ggt tca     1968
 Ser Val Gly Ala Asp His Thr Arg Glu Leu Arg Lys Pro Ser Gly Ser
                 645                 650                 655

 cac agg cct ccc ttc aac gta gtc atc ccc tgg tgg tgg aag caa gac     2016
 His Arg Pro Pro Phe Asn Val Val Ile Pro Trp Trp Trp Lys Gln Asp
             660                 665                 670

 gac ggc ccc tga cgt gcagccacac acagaaaagg ctgctgtgaa cattttatgc     2071
 Asp Gly Pro 
         675

 ttcga                                                               2076




      <210> 440
      <211> 375
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (1)..(375)

      <400> 440
  atg agg cag gga gac atg ggt ttg cta tca cat cac cgg ggg ctg gtg      48
  Met Arg Gln Gly Asp Met Gly Leu Leu Ser His His Arg Gly Leu Val
    1               5                  10                  15

 atg gag gac gag gag aag gca gtg gag atc ttg ggc aac acg gaa gct       96
 Met Glu Asp Glu Glu Lys Ala Val Glu Ile Leu Gly Asn Thr Glu Ala
              20                  25                  30

 gct cat cct cca tcc ccc atc cgc tgc tgc tgg ctc cgc ctc cgc tgc      144
 Ala His Pro Pro Ser Pro Ile Arg Cys Cys Trp Leu Arg Leu Arg Cys
          35                  40                  45

 ttg gca gct act agc att atc tgt ggc tgc tct tgc ctg gga gtc atg      192
 Leu Ala Ala Thr Ser Ile Ile Cys Gly Cys Ser Cys Leu Gly Val Met
      50                  55                  60

 gct ctg gtg ttt gcc atc aag gcg gaa gag cgg cat aaa gca ggc cgg      240
 Ala Leu Val Phe Ala Ile Lys Ala Glu Glu Arg His Lys Ala Gly Arg
  65                  70                  75                  80

 tcc gag gag gca gtg cgc tgg ggg gcc cgg gcc cgg aaa ctc atc ctg      288
 Ser Glu Glu Ala Val Arg Trp Gly Ala Arg Ala Arg Lys Leu Ile Leu
                  85                  90                  95

 gcc agc ttt gct gtc tgg ctt gct gtc ctc att ctg ggt ccc ctg ctg      336
 Ala Ser Phe Ala Val Trp Leu Ala Val Leu Ile Leu Gly Pro Leu Leu
             100                 105                 110

 ctg tgg ttg ctc tcc tac gcc atc gct cag gct gag tga                  375
 Leu Trp Leu Leu Ser Tyr Ala Ile Ala Gln Ala Glu 
         115                 120





      <210> 441
      <211> 561
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (1)..(561)

      <400> 441
  atg tct gac tct cag agc tac ttt caa gca ggc aac aaa gat gtt cga      48
  Met Ser Asp Ser Gln Ser Tyr Phe Gln Ala Gly Asn Lys Asp Val Arg
    1               5                  10                  15

 ttg gag ccc atc tgg cta gag gga gtg aaa tgc aag aag tgg gat ctt       96
 Leu Glu Pro Ile Trp Leu Glu Gly Val Lys Cys Lys Lys Trp Asp Leu
              20                  25                  30

 gtg tgt gat aat gcc tgg aag gtc cat atc gct aag ttc tcc tta ctg      144
 Val Cys Asp Asn Ala Trp Lys Val His Ile Ala Lys Phe Ser Leu Leu
          35                  40                  45

 gtt gga tta atc ttt ggc tac cta ata act gga tgc att gct gac tgg      192
 Val Gly Leu Ile Phe Gly Tyr Leu Ile Thr Gly Cys Ile Ala Asp Trp
      50                  55                  60

 gtc ggc cgg cgg cct gtg ctg ctg ttt tcc atc atc ttc att ctg atc      240
 Val Gly Arg Arg Pro Val Leu Leu Phe Ser Ile Ile Phe Ile Leu Ile
  65                  70                  75                  80

 ttt gga ctg act gtg gca ctg tca gtg aat gtg aca atg ttc agc aca      288
 Phe Gly Leu Thr Val Ala Leu Ser Val Asn Val Thr Met Phe Ser Thr
                  85                  90                  95

 ctc agg ttc ttt gaa gga ttt tgc ctg gct gga atc att ctc acc ttg      336
 Leu Arg Phe Phe Glu Gly Phe Cys Leu Ala Gly Ile Ile Leu Thr Leu
             100                 105                 110

 tat gct tta cag tct gaa gct acc gac cac tcc ctt cct ccc atg agt      384
 Tyr Ala Leu Gln Ser Glu Ala Thr Asp His Ser Leu Pro Pro Met Ser
         115                 120                 125

 ctg aca ggg gaa gat gat gac ctc tgt ttc aga cct gga aag att ggg      432
 Leu Thr Gly Glu Asp Asp Asp Leu Cys Phe Arg Pro Gly Lys Ile Gly
     130                 135                 140

 cag gtg gct gac cag atg aac gtg att gtc atc tgt aaa acc atg aag      480
 Gln Val Ala Asp Gln Met Asn Val Ile Val Ile Cys Lys Thr Met Lys
 145                 150                 155                 160

 ttc cag gga agt gtt ggt gga cat ttg cat gtt tgt gac gtg atg gcc      528
 Phe Gln Gly Ser Val Gly Gly His Leu His Val Cys Asp Val Met Ala
                 165                 170                 175

 acc atc cta ctg caa gca cca gag ctg ccc tga                          561
 Thr Ile Leu Leu Gln Ala Pro Glu Leu Pro 
             180                 185





      <210> 442
      <211> 1953
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (49)..(1953)

      <400> 442
 aagatcctta attaaattaa tccccccccc gagctgcccg gggcgcga atg gca ggc      57
                                                      Met Ala Gly
                                                        1

 tgt ttc cgc gga gta aaa ggt ggc gcc ggt cag tgg tcg ttt cca atg      105
 Cys Phe Arg Gly Val Lys Gly Gly Ala Gly Gln Trp Ser Phe Pro Met
       5                  10                  15

 acg gac att aac cag act gtc aga tcc tgg gga gtc gcg agc ccc gag      153
 Thr Asp Ile Asn Gln Thr Val Arg Ser Trp Gly Val Ala Ser Pro Glu
  20                  25                  30                  35

 ttt gga gtt ttt tcc ccc cac aac gtc aca gtc cga act gca gag gga      201
 Phe Gly Val Phe Ser Pro His Asn Val Thr Val Arg Thr Ala Glu Gly
                  40                  45                  50

 aag gaa ggc ggc agg aag gcg aag ctc ggg ctc cgg cac gta gtt ggg      249
 Lys Glu Gly Gly Arg Lys Ala Lys Leu Gly Leu Arg His Val Val Gly
              55                  60                  65

 aaa ctt gcg ggt cct aga agt cgc ctc ccc gcc ttg ccg gcc gcc ctt      297
 Lys Leu Ala Gly Pro Arg Ser Arg Leu Pro Ala Leu Pro Ala Ala Leu
          70                  75                  80

 gca gcc ccg agc cga gca gca aac ggg tgc ccg cag ctg tgc cgg tgc      345
 Ala Ala Pro Ser Arg Ala Ala Asn Gly Cys Pro Gln Leu Cys Arg Cys
      85                  90                  95

 gag ggg cgg ctg ctg tac tgc gag gcg ctc aac ctc acc gag gcg ccc      393
 Glu Gly Arg Leu Leu Tyr Cys Glu Ala Leu Asn Leu Thr Glu Ala Pro
 100                 105                 110                 115

 cac aac ctg tcc ggc ctg ctg ggc ttg tcc ctg cgc tac aac agc ctc      441
 His Asn Leu Ser Gly Leu Leu Gly Leu Ser Leu Arg Tyr Asn Ser Leu
                 120                 125                 130

 tcg gag ctg cgc gcc ggc cag ttc acg ggg tta atg cag ctc acg tgg      489
 Ser Glu Leu Arg Ala Gly Gln Phe Thr Gly Leu Met Gln Leu Thr Trp
             135                 140                 145

 ctc tat ctg gat cac aat cac atc tgc tcc gtg cag ggg gac gcc ttt      537
 Leu Tyr Leu Asp His Asn His Ile Cys Ser Val Gln Gly Asp Ala Phe
         150                 155                 160

 cag aaa ctg cgc cga gtt aag gaa ctc acg ctg agt tcc aac cag atc      585
 Gln Lys Leu Arg Arg Val Lys Glu Leu Thr Leu Ser Ser Asn Gln Ile
     165                 170                 175

 acc caa ctg ccc aac acc acc ttc cgg ccc atg ccc aac ctg cgc agc      633
 Thr Gln Leu Pro Asn Thr Thr Phe Arg Pro Met Pro Asn Leu Arg Ser
 180                 185                 190                 195

 gtg gac ctc tcg tac aac aag ctg cag gcg ctc gcg ccc gac ctc ttc      681
 Val Asp Leu Ser Tyr Asn Lys Leu Gln Ala Leu Ala Pro Asp Leu Phe
                 200                 205                 210

 cac ggg ctg cgg aag ctc acc acg ctg cat atg cgg gcc aac gcc atc      729
 His Gly Leu Arg Lys Leu Thr Thr Leu His Met Arg Ala Asn Ala Ile
             215                 220                 225

 cag ttt gtg ccc gtg cgc atc ttc cag gac tgc cgc agc ctc aag ttt      777
 Gln Phe Val Pro Val Arg Ile Phe Gln Asp Cys Arg Ser Leu Lys Phe
         230                 235                 240

 ctc gac atc gga tac aat cag ctc aag agt ctg gcg cgc aac tct ttc      825
 Leu Asp Ile Gly Tyr Asn Gln Leu Lys Ser Leu Ala Arg Asn Ser Phe
     245                 250                 255

 gcc ggc ttg ttt aag ctc acc gag ctg cac ctc gag cac aac gac ttg      873
 Ala Gly Leu Phe Lys Leu Thr Glu Leu His Leu Glu His Asn Asp Leu
 260                 265                 270                 275

 gtc aag gtg aac ttc gcc cac ttc ccg cgc ctc atc tcc ctg cac tcg      921
 Val Lys Val Asn Phe Ala His Phe Pro Arg Leu Ile Ser Leu His Ser
                 280                 285                 290

 ctc tgc ctg cgg agg aac aag gtg gcc att gtg gtc agc tcg ctg gac      969
 Leu Cys Leu Arg Arg Asn Lys Val Ala Ile Val Val Ser Ser Leu Asp
             295                 300                 305

 tgg gtt tgg aac ctg gag aaa atg gac ttg tcg ggc aac gag atc gag     1017
 Trp Val Trp Asn Leu Glu Lys Met Asp Leu Ser Gly Asn Glu Ile Glu
         310                 315                 320

 tac atg gag ccc cat gtg ttc gag acc gtg ccg cac ctg cag tcc ctg     1065
 Tyr Met Glu Pro His Val Phe Glu Thr Val Pro His Leu Gln Ser Leu
     325                 330                 335

 cag ctg gac tcc aac cgc ctc acc tac atc gag ccc cgg atc ctc aac     1113
 Gln Leu Asp Ser Asn Arg Leu Thr Tyr Ile Glu Pro Arg Ile Leu Asn
 340                 345                 350                 355

 tct tgg aag tcc ctg aca agc atc acc ctg gcc ggg aac ctg tgg gat     1161
 Ser Trp Lys Ser Leu Thr Ser Ile Thr Leu Ala Gly Asn Leu Trp Asp
                 360                 365                 370

 tgc ggg cgc aac gtg tgt gcc cta gcc tcg tgg ctc aac aac ttc cag     1209
 Cys Gly Arg Asn Val Cys Ala Leu Ala Ser Trp Leu Asn Asn Phe Gln
             375                 380                 385

 ggg cgc tac gat ggc aac ttg cag tgc gcc agc ccg gag tac gca cag     1257
 Gly Arg Tyr Asp Gly Asn Leu Gln Cys Ala Ser Pro Glu Tyr Ala Gln
         390                 395                 400

 ggc gag gac gtc ctg gac gcc gtg tac gcc ttc cac ctg tgc gag gat     1305
 Gly Glu Asp Val Leu Asp Ala Val Tyr Ala Phe His Leu Cys Glu Asp
     405                 410                 415

 ggg gcc gag ccc acc agc ggc cac ctg ctc tcg gcc gtc acc aac cgc     1353
 Gly Ala Glu Pro Thr Ser Gly His Leu Leu Ser Ala Val Thr Asn Arg
 420                 425                 430                 435

 agt gat ctg ggg ccc cct gcc agc tcg gcc acc acg ctc gcg gac ggc     1401
 Ser Asp Leu Gly Pro Pro Ala Ser Ser Ala Thr Thr Leu Ala Asp Gly
                 440                 445                 450

 ggg gag ggg cag cac gac ggc aca ttc gag cct gcc acc gtg gct ctt     1449
 Gly Glu Gly Gln His Asp Gly Thr Phe Glu Pro Ala Thr Val Ala Leu
             455                 460                 465

 cca ggc ggc gag cac gcc gag aac gcc gtg cag atc cac aag gtg gtc     1497
 Pro Gly Gly Glu His Ala Glu Asn Ala Val Gln Ile His Lys Val Val
         470                 475                 480

 acg ggc acc atg gcc ctc atc ttc tcc ttc ctc atc gtg gtc ctg gtg     1545
 Thr Gly Thr Met Ala Leu Ile Phe Ser Phe Leu Ile Val Val Leu Val
     485                 490                 495

 ctc tac gtg tcc tgg aag tgt ttc cca gcc agc ctc agg cag ctc aga     1593
 Leu Tyr Val Ser Trp Lys Cys Phe Pro Ala Ser Leu Arg Gln Leu Arg
 500                 505                 510                 515

 cag tgc ttt gtc acg cag cgc agg aag caa aag cag aaa cag acc atg     1641
 Gln Cys Phe Val Thr Gln Arg Arg Lys Gln Lys Gln Lys Gln Thr Met
                 520                 525                 530

 cat cag atg gct gcc atg tct gcc cag gaa tac tac gtt gat tac aaa     1689
 His Gln Met Ala Ala Met Ser Ala Gln Glu Tyr Tyr Val Asp Tyr Lys
             535                 540                 545

 ccg aac cac att gag gga gcc ctg gtg atc atc aac gag tat ggc tcg     1737
 Pro Asn His Ile Glu Gly Ala Leu Val Ile Ile Asn Glu Tyr Gly Ser
         550                 555                 560

 tgt acc tgc cac cag cag ccc gcg agg gaa tgc gag gtt tcc agg tcc     1785
 Cys Thr Cys His Gln Gln Pro Ala Arg Glu Cys Glu Val Ser Arg Ser
     565                 570                 575

 atc att gag att tca gtt tct att gaa cta aag agt gag gag gtg gtg     1833
 Ile Ile Glu Ile Ser Val Ser Ile Glu Leu Lys Ser Glu Glu Val Val
 580                 585                 590                 595

 gta gtg gca gtt ggt ggg tgc aga gaa ggg aag ggg aag gct gtg tgc     1881
 Val Val Ala Val Gly Gly Cys Arg Glu Gly Lys Gly Lys Ala Val Cys
                 600                 605                 610

 att gga cgg agg gct cct tca tca gat gac aat tta agc aaa tgt atg     1929
 Ile Gly Arg Arg Ala Pro Ser Ser Asp Asp Asn Leu Ser Lys Cys Met
             615                 620                 625

 att gaa ata aac tgt cat gga tga                                     1953
 Ile Glu Ile Asn Cys His Gly 
         630





      <210> 443
      <211> 824
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (20)..(781)

      <400> 443
 cgtccagggc accttctgc atg gcc gcc tgg ggc ttc tgc ttc gcc gtc tct      52
                      Met Ala Ala Trp Gly Phe Cys Phe Ala Val Ser
                        1               5                  10

 gcg ctg gtg gtg gcc tgt gag ttc aca cgg ctc cac ggc tgc ctg cgg      100
 Ala Leu Val Val Ala Cys Glu Phe Thr Arg Leu His Gly Cys Leu Arg
              15                  20                  25

 ctc tcc tgg ggc aac ttc acc gcc gcc ttc gcc atg ctg gcc acc ctg      148
 Leu Ser Trp Gly Asn Phe Thr Ala Ala Phe Ala Met Leu Ala Thr Leu
          30                  35                  40

 cta tgc gcg acg gct gcg gtc ctg tat ccg ctg tac ttt gcc cgg cgg      196
 Leu Cys Ala Thr Ala Ala Val Leu Tyr Pro Leu Tyr Phe Ala Arg Arg
      45                  50                  55

 gag tgt ccc ccc gag ccc gcc ggc tgt gct gcc agg gac ttc cgc ctg      244
 Glu Cys Pro Pro Glu Pro Ala Gly Cys Ala Ala Arg Asp Phe Arg Leu
  60                  65                  70                  75

 gca gcc agt gtc ttc gcc ggg ctc ctc ttc ctg gcc tac gct gtg gag      292
 Ala Ala Ser Val Phe Ala Gly Leu Leu Phe Leu Ala Tyr Ala Val Glu
                  80                  85                  90

 gtg gcc ctg acg cgg gcc cgg ccc ggc cag gtg agc agc tat atg gcc      340
 Val Ala Leu Thr Arg Ala Arg Pro Gly Gln Val Ser Ser Tyr Met Ala
              95                 100                 105

 acg gtg tcg ggg ctc ctc aag atc gtc cag gcc ttc gtg gcc tgc atc      388
 Thr Val Ser Gly Leu Leu Lys Ile Val Gln Ala Phe Val Ala Cys Ile
         110                 115                 120

 atc ttc ggg gcg ctg gtc cat gac agc cgc tac ggg cgc tac gtg gcc      436
 Ile Phe Gly Ala Leu Val His Asp Ser Arg Tyr Gly Arg Tyr Val Ala
     125                 130                 135

 acc cag tgg tgc gtg gcc gtc tac agc ctg tgc ttc ctg gcc aca gtg      484
 Thr Gln Trp Cys Val Ala Val Tyr Ser Leu Cys Phe Leu Ala Thr Val
 140                 145                 150                 155

 gcc gtg gtg gcc ctg agt gtg atg ggc cac aca ggg ggc ctg ggc tgc      532
 Ala Val Val Ala Leu Ser Val Met Gly His Thr Gly Gly Leu Gly Cys
                 160                 165                 170

 ccc ttt gac cgg ctg gtg gtg gtg tac acc ttc ctg gct gtg ctc ctg      580
 Pro Phe Asp Arg Leu Val Val Val Tyr Thr Phe Leu Ala Val Leu Leu
             175                 180                 185

 tac ctc agc gcc gcc gtg atc tgg cca gtc ttc tgt ttc gat ccc aag      628
 Tyr Leu Ser Ala Ala Val Ile Trp Pro Val Phe Cys Phe Asp Pro Lys
         190                 195                 200

 tac ggt gag ccc aaa cgg ccc ccc aac tgt gct cgg ggc agc tgt ccc      676
 Tyr Gly Glu Pro Lys Arg Pro Pro Asn Cys Ala Arg Gly Ser Cys Pro
     205                 210                 215

 tgg gac agc cag ctg gtg gtg gcc atc ttc acc tac gtc aac ctg ctc      724
 Trp Asp Ser Gln Leu Val Val Ala Ile Phe Thr Tyr Val Asn Leu Leu
 220                 225                 230                 235

 ctg tac gtc gtt gac ctc gcc tac tcc cag agg att cgc ttc gtg ccc      772
 Leu Tyr Val Val Asp Leu Ala Tyr Ser Gln Arg Ile Arg Phe Val Pro
                 240                 245                 250

 agc ctg tag cccacagtgg cagcccaccc acctctgctc tctggccacc agc          824
 Ser Leu 






      <210> 444
      <211> 554
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (106)..(507)

      <400> 444
 gaattcgagg cgttcgtcta gatttgtcgg cttgcgggga gacttcagga gtcgctgtct     60

 ctgaacttcc agcctcagag accgccgccc ttgtccccga gggcc    atg ggc cgg     114
                                                      Met Gly Arg
                                                        1

 gtc tca ggg ctt gtg ccc tct cgc ttc ctg acg ctc ctg gcg cat ctg      162
 Val Ser Gly Leu Val Pro Ser Arg Phe Leu Thr Leu Leu Ala His Leu
       5                  10                  15

 gtg gtc gtc atc acc tta ttc tgg tcc cgg gac agc aac ata cag gcc      210
 Val Val Val Ile Thr Leu Phe Trp Ser Arg Asp Ser Asn Ile Gln Ala
  20                  25                  30                  35

 tgc ctg cct ctc acg ttc acc ccc gag gag tat gac aag cag gac att      258
 Cys Leu Pro Leu Thr Phe Thr Pro Glu Glu Tyr Asp Lys Gln Asp Ile
                  40                  45                  50

 cag ctg gtg gcc gcg ctc tct gtc acc ctg ggc ctc ttt gca gtg gag      306
 Gln Leu Val Ala Ala Leu Ser Val Thr Leu Gly Leu Phe Ala Val Glu
              55                  60                  65

 ctg gcc ggt ttc ctc tca gga gtc tcc atg ttc aac agc acc cag agc      354
 Leu Ala Gly Phe Leu Ser Gly Val Ser Met Phe Asn Ser Thr Gln Ser
          70                  75                  80

 ctc atc tcc att ggg gct cac tgt agt gca tcc gtg gcc ctg tcc ttc      402
 Leu Ile Ser Ile Gly Ala His Cys Ser Ala Ser Val Ala Leu Ser Phe
      85                  90                  95

 ttc ata ttc gag cgt tgg gag tgc act acg tat tgg tac att ttt gtc      450
 Phe Ile Phe Glu Arg Trp Glu Cys Thr Thr Tyr Trp Tyr Ile Phe Val
 100                 105                 110                 115

 ttc tgc agg tgt ggt agc atc caa tat ttg ggg atg agg gag gaa ggt      498
 Phe Cys Arg Cys Gly Ser Ile Gln Tyr Leu Gly Met Arg Glu Glu Gly
                 120                 125                 130

 tgg ccc taa acctgaa ggtttttccc ctacccagcc ctttcctcca tgtgtgagat      554
 Trp Pro 






      <210> 445
      <211> 1255
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (1)..(1188)

      <400> 445
  atg ggc cgg gcc cgg cgc ttc cag tgg ccg ctg ctg ctg ctg tgg gcg      48
  Met Gly Arg Ala Arg Arg Phe Gln Trp Pro Leu Leu Leu Leu Trp Ala
    1               5                  10                  15

 gcc gcg gcg ggg cca ggg gca gga cag gaa gta cag aca gag aac gtg       96
 Ala Ala Ala Gly Pro Gly Ala Gly Gln Glu Val Gln Thr Glu Asn Val
              20                  25                  30

 aca gtg gct gag ggt ggg gtg gct gag atc acc tgc cgt ctg cac cag      144
 Thr Val Ala Glu Gly Gly Val Ala Glu Ile Thr Cys Arg Leu His Gln
          35                  40                  45

 tat gat ggg tcc ata gtt gtc atc cag aac cca gcc cgg cag acc ctc      192
 Tyr Asp Gly Ser Ile Val Val Ile Gln Asn Pro Ala Arg Gln Thr Leu
      50                  55                  60

 ttc ttc aat ggc acc cgt gcc ttg aag gat gag cgt ttc cag ctt gag      240
 Phe Phe Asn Gly Thr Arg Ala Leu Lys Asp Glu Arg Phe Gln Leu Glu
  65                  70                  75                  80

 gag ttc tcc cca cgc cgg gtg cgg atc cgg ctc tca gat gcc cgc ctg      288
 Glu Phe Ser Pro Arg Arg Val Arg Ile Arg Leu Ser Asp Ala Arg Leu
                  85                  90                  95

 gag gac gag ggg ggc tat ttc tgc cag ctc tac aca gaa gac acc cac      336
 Glu Asp Glu Gly Gly Tyr Phe Cys Gln Leu Tyr Thr Glu Asp Thr His
             100                 105                 110

 cac cag att gcc acg ctc acg gta cta gtg gcc cca gag aat cct gtg      384
 His Gln Ile Ala Thr Leu Thr Val Leu Val Ala Pro Glu Asn Pro Val
         115                 120                 125

 gtg gag gtc cgg gag cag gcg gta gag ggc ggc gag gtg gag ctc agc      432
 Val Glu Val Arg Glu Gln Ala Val Glu Gly Gly Glu Val Glu Leu Ser
     130                 135                 140

 tgc ctc gtt ccg cgg tcc cgt ccg gct gcc acc ctg cgc tgg tac cgg      480
 Cys Leu Val Pro Arg Ser Arg Pro Ala Ala Thr Leu Arg Trp Tyr Arg
 145                 150                 155                 160

 gac cgc aag gag ctg aaa gtg tct gac cgg ggt gtg gca gga gtg agc      528
 Asp Arg Lys Glu Leu Lys Val Ser Asp Arg Gly Val Ala Gly Val Ser
                 165                 170                 175

 agc agc cag gaa aat ggc aag gtc tgg agc gtg gca agc aca gta cgg      576
 Ser Ser Gln Glu Asn Gly Lys Val Trp Ser Val Ala Ser Thr Val Arg
             180                 185                 190

 ttt cgt gtg gac cgt aag gac gac ggt ggt atc atc atc tgt gag gcg      624
 Phe Arg Val Asp Arg Lys Asp Asp Gly Gly Ile Ile Ile Cys Glu Ala
         195                 200                 205

 cag aac cag gcg ctg ccc tcc gga cac agc aag cag acg cag tac gtg      672
 Gln Asn Gln Ala Leu Pro Ser Gly His Ser Lys Gln Thr Gln Tyr Val
     210                 215                 220

 ctg gat gtg cag tac tcc ccc acg gcc cgg att cat gcc tcc caa gct      720
 Leu Asp Val Gln Tyr Ser Pro Thr Ala Arg Ile His Ala Ser Gln Ala
 225                 230                 235                 240

 gtg gtg agg gag gga gac acg ctg gtg ttg acg tgt gct gtc acg ggg      768
 Val Val Arg Glu Gly Asp Thr Leu Val Leu Thr Cys Ala Val Thr Gly
                 245                 250                 255

 aac ccc agg cca aac cag atc cgc tgg aac cgc ggg aat gag tct ttg      816
 Asn Pro Arg Pro Asn Gln Ile Arg Trp Asn Arg Gly Asn Glu Ser Leu
             260                 265                 270

 ccg gag agg gcg gag gcc gtg gga gag acg ctc acg ctg ccg ggt ctg      864
 Pro Glu Arg Ala Glu Ala Val Gly Glu Thr Leu Thr Leu Pro Gly Leu
         275                 280                 285

 gta tcc gcg gat aac ggc acc tac act tgc gag gcg tcc aat aag cac      912
 Val Ser Ala Asp Asn Gly Thr Tyr Thr Cys Glu Ala Ser Asn Lys His
     290                 295                 300

 ggc cat gcg agg gcg ctc tac gta ctt gtg gtc tac gac cct ggt gcg      960
 Gly His Ala Arg Ala Leu Tyr Val Leu Val Val Tyr Asp Pro Gly Ala
 305                 310                 315                 320

 gtg gta gag gct cag acg tcg gtt ccc tat gcc att gtg ggc ggt atc     1008
 Val Val Glu Ala Gln Thr Ser Val Pro Tyr Ala Ile Val Gly Gly Ile
                 325                 330                 335

 ctg gcg ctg ctg gtg ttt ctg atc ata tgt gtg cta gtg ggc atg gtc     1056
 Leu Ala Leu Leu Val Phe Leu Ile Ile Cys Val Leu Val Gly Met Val
             340                 345                 350

 tgg tgc tcg gta cgg cag aag ggt tcc tat ctg acc cac gaa gcc agt     1104
 Trp Cys Ser Val Arg Gln Lys Gly Ser Tyr Leu Thr His Glu Ala Ser
         355                 360                 365

 ggc ttg gat gaa cag gga gaa gta aga gaa gcc ttc ctc aat ggc agc     1152
 Gly Leu Asp Glu Gln Gly Glu Val Arg Glu Ala Phe Leu Asn Gly Ser
     370                 375                 380

 gac gga cac aag agg aaa gag gaa ttc ttc atc tga ccct atccccaccc     1202
 Asp Gly His Lys Arg Lys Glu Glu Phe Phe Ile 
 385                 390                 395

 caggcctagg cctgggcctg ggctggggtc ccccccactg ccagctgcaa gcc          1255




      <210> 446
      <211> 2485
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (70)..(1515)

      <400> 446
 cgtcgccgtc cccgtctcct gccaggcgcg gagccctgcg agccgcgggt gggccccagg     60

 cgcgcagac    atg ggc tgc tcc gcc aaa gcg cgc tgg gct gcc ggg gcg     108
              Met Gly Cys Ser Ala Lys Ala Arg Trp Ala Ala Gly Ala
                1               5                  10

 ctg ggc gtc gcg ggg cta ctg tgc gct gtg ctg ggc gct gtc atg atc      156
 Leu Gly Val Ala Gly Leu Leu Cys Ala Val Leu Gly Ala Val Met Ile
      15                  20                  25

 gtg atg gtg ccg tcg ctc atc aag cag cag gtc ctt aag aac gtg cgc      204
 Val Met Val Pro Ser Leu Ile Lys Gln Gln Val Leu Lys Asn Val Arg
  30                  35                  40                  45

 atc gac ccc agt agc ctg tcc ttc aac atg tgg aag gag atc cct atc      252
 Ile Asp Pro Ser Ser Leu Ser Phe Asn Met Trp Lys Glu Ile Pro Ile
                  50                  55                  60

 ccc ttc tat ctc tcc gtc tac ttc ttt gac gtc atg aac ccc agc gag      300
 Pro Phe Tyr Leu Ser Val Tyr Phe Phe Asp Val Met Asn Pro Ser Glu
              65                  70                  75

 atc ctg aag ggc gag aag ccg cag gtg cgg gag cgc ggg ccc tac gtg      348
 Ile Leu Lys Gly Glu Lys Pro Gln Val Arg Glu Arg Gly Pro Tyr Val
          80                  85                  90

 tac agg gag tcc agg cac aaa agc aac atc acc ttc aac aac aac gac      396
 Tyr Arg Glu Ser Arg His Lys Ser Asn Ile Thr Phe Asn Asn Asn Asp
      95                 100                 105

 acc gtg tcc ttc ctc gag tac cgc acc ttc cag ttc cag ccc tcc aag      444
 Thr Val Ser Phe Leu Glu Tyr Arg Thr Phe Gln Phe Gln Pro Ser Lys
 110                 115                 120                 125

 tcc cac ggc tcg gag agc gac tac atc gtc atg ccc aac atc ctg gtc      492
 Ser His Gly Ser Glu Ser Asp Tyr Ile Val Met Pro Asn Ile Leu Val
                 130                 135                 140

 ttg ggt gcg gcg gtg atg atg gag aat aag ccc atg acc ctg aag ctc      540
 Leu Gly Ala Ala Val Met Met Glu Asn Lys Pro Met Thr Leu Lys Leu
             145                 150                 155

 atc atg acc ttg gca ttc acc acc ctc ggc gaa cgt gcc ttc atg aac      588
 Ile Met Thr Leu Ala Phe Thr Thr Leu Gly Glu Arg Ala Phe Met Asn
         160                 165                 170

 cgc act gtg ggt gag atc atg tgg ggc tac aag gac ccc ctt gtg aat      636
 Arg Thr Val Gly Glu Ile Met Trp Gly Tyr Lys Asp Pro Leu Val Asn
     175                 180                 185

 ctc atc aac aag tac ttt cca ggc atg ttc ccc ttc aag gac aag ttc      684
 Leu Ile Asn Lys Tyr Phe Pro Gly Met Phe Pro Phe Lys Asp Lys Phe
 190                 195                 200                 205

 gga tta ttt gct gag ctc aac aac tcc gac tct ggg ctc ttc acg gtg      732
 Gly Leu Phe Ala Glu Leu Asn Asn Ser Asp Ser Gly Leu Phe Thr Val
                 210                 215                 220

 ttc acg ggg gtc cag aac atc agc agg atc cac ctc gtg gac aag tgg      780
 Phe Thr Gly Val Gln Asn Ile Ser Arg Ile His Leu Val Asp Lys Trp
             225                 230                 235

 aac ggg ctg agc aag gtt gac ttc tgg cat tcc gat cag tgc aac atg      828
 Asn Gly Leu Ser Lys Val Asp Phe Trp His Ser Asp Gln Cys Asn Met
         240                 245                 250

 atc aat gga act tct ggg caa atg tgg ccg ccc ttc atg act cct gag      876
 Ile Asn Gly Thr Ser Gly Gln Met Trp Pro Pro Phe Met Thr Pro Glu
     255                 260                 265

 tcc tcg ctg gag ttc tac agc ccg gag gcc tgc cga tcc atg aag cta      924
 Ser Ser Leu Glu Phe Tyr Ser Pro Glu Ala Cys Arg Ser Met Lys Leu
 270                 275                 280                 285

 atg tac aag gag tca ggg gtg ttt gaa ggc atc ccc acc tat cgc ttc      972
 Met Tyr Lys Glu Ser Gly Val Phe Glu Gly Ile Pro Thr Tyr Arg Phe
                 290                 295                 300

 gtg gct ccc aaa acc ctg ttt gcc aac ggg tcc atc tac cca ccc aac     1020
 Val Ala Pro Lys Thr Leu Phe Ala Asn Gly Ser Ile Tyr Pro Pro Asn
             305                 310                 315

 gaa ggc ttc tgc ccg tgc ctg gag tct gga att cag aac gtc agc acc     1068
 Glu Gly Phe Cys Pro Cys Leu Glu Ser Gly Ile Gln Asn Val Ser Thr
         320                 325                 330

 tgc agg ttc agt gcc ccc ttg ttt ctc tcc cat cct cac ttc ctc aac     1116
 Cys Arg Phe Ser Ala Pro Leu Phe Leu Ser His Pro His Phe Leu Asn
     335                 340                 345

 gcc gac ccg gtt ctg gca gaa gcg gtg act ggc ctg cac cct aac cag     1164
 Ala Asp Pro Val Leu Ala Glu Ala Val Thr Gly Leu His Pro Asn Gln
 350                 355                 360                 365

 gag gca cac tcc ttg ttc ctg gac atc cac ccg gtc acg gga atc ccc     1212
 Glu Ala His Ser Leu Phe Leu Asp Ile His Pro Val Thr Gly Ile Pro
                 370                 375                 380

 atg aac tgc tct gtg aaa ctg cag ctg agc ctc tac atg aaa tct gtc     1260
 Met Asn Cys Ser Val Lys Leu Gln Leu Ser Leu Tyr Met Lys Ser Val
             385                 390                 395

 gca ggc att gga caa act ggg aag att gag cct gtg gtc ctg ccg ctg     1308
 Ala Gly Ile Gly Gln Thr Gly Lys Ile Glu Pro Val Val Leu Pro Leu
         400                 405                 410

 ctc tgg ttt gca gag agc ggg gcc atg gag ggg gag act ctt cac aca     1356
 Leu Trp Phe Ala Glu Ser Gly Ala Met Glu Gly Glu Thr Leu His Thr
     415                 420                 425

 ttc tac act cag ctg gtg ttg atg ccc aag gag aaa tgc tat tta ttt     1404
 Phe Tyr Thr Gln Leu Val Leu Met Pro Lys Glu Lys Cys Tyr Leu Phe
 430                 435                 440                 445

 tgg agt agt agt aaa aag ggc tca aag gat aag gag gcc att cag gcc     1452
 Trp Ser Ser Ser Lys Lys Gly Ser Lys Asp Lys Glu Ala Ile Gln Ala
                 450                 455                 460

 tat tct gaa tcc ctg atg aca tca gct ccc aag ggc tct gtg ctg cag     1500
 Tyr Ser Glu Ser Leu Met Thr Ser Ala Pro Lys Gly Ser Val Leu Gln
             465                 470                 475

 gaa gca aaa ctg tag ggtcctgagg acaccgtgag ccagccaggc ctggccgctg     1555
 Glu Ala Lys Leu 
         480

 ggcctgaccg gccccccagc ccctacaccc cgcttctccc ggactctccc agcggacagc   1615

 cccccagccc cacagcctga gcctcccagc tgccatgtgc ctgttgcaca cctgcacaca   1675

 cgccctggca cacatacaca catgcgtgca ggcttgtgca gacactcagg gatggagctg   1735

 ctgctgaagg gacttgtagg gagaggctcg tcaacaagca ctgttctgga accttctctc   1795

 cacgtggccc acaggcctga ccacaggggc tgtgggtcct gcgtcccctt cctcgggtga   1855

 gcctggcctg tcccgttcag ccgttgggcc caggcttcct cccctccaag gtgaaacact   1915

 gcagtcccgg tgtggtggct ccccatgcag gacgggccag gctgggagtg ccgccttcct   1975

 gtgccaaatt cagtggggac tcagtgccca ggccctggcc acgagctttg gccttggtct   2035

 acctgccagg ccaggcaaag cgcctttaca caggcctcgg aaaacaatgg agtgagcaca   2095

 agatgccctg tgcagctgcc cgagggtctc cgcccacccc ggccggactt tgatcccccc   2155

 gaagtcttca caggcactgc atcgggttgt ctggcgccct tttcctccag cctaaactga   2215

 catcatccta tggactgagc cggccactct ctggccgaag tggccgcagg ctgtgccccc   2275

 gagctgcccc caccccctca cagggtccct cagattatag gtgcccaggc tgaggtgaag   2335

 aggcctgggg gccctgcctt ccgggcgctc ctggaccctg gggcaaacct gtgacccttt   2395

 tctactggaa tagaaatgag ttttatcatc tttgaaaaat aattcactct tgaagtaata   2455

 aacgtttaaa aaaatgggaa aaaaaaaaaa                                    2485




      <210> 447
      <211> 1128
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (1)..(1128)

      <400> 447
  atg aag agg cag agc cca gag gaa ttt tgg ggc agt gaa gcc cag ctg      48
  Met Lys Arg Gln Ser Pro Glu Glu Phe Trp Gly Ser Glu Ala Gln Leu
    1               5                  10                  15

 tat gac gct gat gtg gtg tcc acg ttg gtc aaa acc cat aga atg tac       96
 Tyr Asp Ala Asp Val Val Ser Thr Leu Val Lys Thr His Arg Met Tyr
              20                  25                  30

 acg aag agt gag ccc cga cgg gga ctc cct gac cct ggc cac ctg gcc      144
 Thr Lys Ser Glu Pro Arg Arg Gly Leu Pro Asp Pro Gly His Leu Ala
          35                  40                  45

 atg gac aca gcc agc tgc ccc gtc gca tcc ctg tcc atg ctg cac agt      192
 Met Asp Thr Ala Ser Cys Pro Val Ala Ser Leu Ser Met Leu His Ser
      50                  55                  60

 tac atg gcc ccg tta cgg ttc ccc cga cgc cct tct gtt ctc aag ctg      240
 Tyr Met Ala Pro Leu Arg Phe Pro Arg Arg Pro Ser Val Leu Lys Leu
  65                  70                  75                  80

 tgt ctc gcc aag aac ccg cag gaa gag cga cgt gac gac tgt gtc gtc      288
 Cys Leu Ala Lys Asn Pro Gln Glu Glu Arg Arg Asp Asp Cys Val Val
                  85                  90                  95

 cat ccg gag tct cag gca cag gtg cgg ctt ggt ggc ccg gag cga tcc      336
 His Pro Glu Ser Gln Ala Gln Val Arg Leu Gly Gly Pro Glu Arg Ser
             100                 105                 110

 gct ggg att gct ccc cag ggc agc cac gtg gag gac acc gga gcc gct      384
 Ala Gly Ile Ala Pro Gln Gly Ser His Val Glu Asp Thr Gly Ala Ala
         115                 120                 125

 ggg gtc agg tgg ttc agc ctc cgc aca cgc tcc tgg tcc tgg gcc cac      432
 Gly Val Arg Trp Phe Ser Leu Arg Thr Arg Ser Trp Ser Trp Ala His
     130                 135                 140

 ccc ggc aag gat gcc att gat gaa tcc tca ctt gtt cct cgc ctg gcc      480
 Pro Gly Lys Asp Ala Ile Asp Glu Ser Ser Leu Val Pro Arg Leu Ala
 145                 150                 155                 160

 tta ctc tgg gag ctg cag ctt agg gga ttg tgc ctg ggg acg ggg ctg      528
 Leu Leu Trp Glu Leu Gln Leu Arg Gly Leu Cys Leu Gly Thr Gly Leu
                 165                 170                 175

 tgg ggc gta gtc tgt cta tct gcc ttc ctg cct gtc cat ctg ctt gtc      576
 Trp Gly Val Val Cys Leu Ser Ala Phe Leu Pro Val His Leu Leu Val
             180                 185                 190

 tgt ctg cct gtc tgt ctg cct gcc tgt ctg tcc atc tgt ctg tcc acc      624
 Cys Leu Pro Val Cys Leu Pro Ala Cys Leu Ser Ile Cys Leu Ser Thr
         195                 200                 205

 tgc ctg tct gtc tgc ctt ctt gcc tgt ctg ccc tgc ctg tct gtc tgc      672
 Cys Leu Ser Val Cys Leu Leu Ala Cys Leu Pro Cys Leu Ser Val Cys
     210                 215                 220

 ctg tct gtc cat ctg tct gtc tgc cta cct atc tat cta tct gcc ttc      720
 Leu Ser Val His Leu Ser Val Cys Leu Pro Ile Tyr Leu Ser Ala Phe
 225                 230                 235                 240

 ctg cct gtc tgc cct gcc tgt ctg tct gcc tgt ctg cct gcc tgt ctg      768
 Leu Pro Val Cys Pro Ala Cys Leu Ser Ala Cys Leu Pro Ala Cys Leu
                 245                 250                 255

 tcc atc tgt ctg tcc acc tgc cta tct tcc ttc ctg ctt gtc tgc cct      816
 Ser Ile Cys Leu Ser Thr Cys Leu Ser Ser Phe Leu Leu Val Cys Pro
             260                 265                 270

 gcc tgt ctg tct gcc tgt ctg tcc atc cat ctg tcc atc tac ctg tct      864
 Ala Cys Leu Ser Ala Cys Leu Ser Ile His Leu Ser Ile Tyr Leu Ser
         275                 280                 285

 gtc tgc ctt cct gcc tgt ttg cct gtc tgt ctg tct gcc tgt ctg tcc      912
 Val Cys Leu Pro Ala Cys Leu Pro Val Cys Leu Ser Ala Cys Leu Ser
     290                 295                 300

 gcc tgc ctg tct gtc ttc ctg tct gtc cgc ctg cct gtc tgt ctg cct      960
 Ala Cys Leu Ser Val Phe Leu Ser Val Arg Leu Pro Val Cys Leu Pro
 305                 310                 315                 320

 gcc tgt ctg tct tcc tgt ctg ttt gcc tgc cta tct tcc tgt ctg tcc     1008
 Ala Cys Leu Ser Ser Cys Leu Phe Ala Cys Leu Ser Ser Cys Leu Ser
                 325                 330                 335

 gcc tgc ctg tgt gtc tgc ctg tct gtc tgc atg tgt gct caa aca cgg     1056
 Ala Cys Leu Cys Val Cys Leu Ser Val Cys Met Cys Ala Gln Thr Arg
             340                 345                 350

 ctc att cag ttc ctg gtt tct ttg gaa atg cag aga ctt ttg cag aaa     1104
 Leu Ile Gln Phe Leu Val Ser Leu Glu Met Gln Arg Leu Leu Gln Lys
         355                 360                 365

 gtc cac cta atg gct ctt gca taa                                     1128
 Val His Leu Met Ala Leu Ala 
     370                 375





      <210> 448
      <211> 1574
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (156)..(1520)

      <400> 448
 atctgaagaa gtgggatgtg caaaagcgcc ggctggaaat cccggctgtg tctccgtcaa     60

 ctctttacgc aacagaggtc tccccctgcc cttggtttct accgggccgc ctgctcccac    120

 tcggcgaaaa aaattacaca acagcagccg cggcg   atg acg tgg agg gct gcc     173
                                          Met Thr Trp Arg Ala Ala
                                            1               5

 gcc tcc acg tgc gcg gcg ctc ctg att ctg ctg tgg gcg ctg acg acc      221
 Ala Ser Thr Cys Ala Ala Leu Leu Ile Leu Leu Trp Ala Leu Thr Thr
              10                  15                  20

 gaa ggt gat ctg aaa gta gag atg atg gca ggg ggg act cag atc aca      269
 Glu Gly Asp Leu Lys Val Glu Met Met Ala Gly Gly Thr Gln Ile Thr
          25                  30                  35

 ccc ctg aat gac aat gtc acc ata ttc tgc aat atc ttt tat tcc caa      317
 Pro Leu Asn Asp Asn Val Thr Ile Phe Cys Asn Ile Phe Tyr Ser Gln
      40                  45                  50

 ccc ctc aac atc acg tct atg ggt atc acc tgg ttt tgg aag agt ctg      365
 Pro Leu Asn Ile Thr Ser Met Gly Ile Thr Trp Phe Trp Lys Ser Leu
  55                  60                  65                  70

 acg ttt gac aaa gaa gtc aaa gtc ttt gaa ttt ttt gga gat cac caa      413
 Thr Phe Asp Lys Glu Val Lys Val Phe Glu Phe Phe Gly Asp His Gln
                  75                  80                  85

 gag gca ttc cga cct gga gcc att gtg tct cca tgg agg ctg aag agt      461
 Glu Ala Phe Arg Pro Gly Ala Ile Val Ser Pro Trp Arg Leu Lys Ser
              90                  95                 100

 ggg gac gcc tca ctg cgg ctg cct gga atc cag ctg gag gaa gca gga      509
 Gly Asp Ala Ser Leu Arg Leu Pro Gly Ile Gln Leu Glu Glu Ala Gly
         105                 110                 115

 gag tac cga tgt gag gtg gtg gtc acc cct ctg aag gca cag gga aca      557
 Glu Tyr Arg Cys Glu Val Val Val Thr Pro Leu Lys Ala Gln Gly Thr
     120                 125                 130

 gtc cag ctt gaa gtt gtg gct tcc cca gcc agc aga ttg ttg ctg gat      605
 Val Gln Leu Glu Val Val Ala Ser Pro Ala Ser Arg Leu Leu Leu Asp
 135                 140                 145                 150

 caa gtg ggc atg aaa gag aat gaa gac aaa tat atg tgt gag tca agt      653
 Gln Val Gly Met Lys Glu Asn Glu Asp Lys Tyr Met Cys Glu Ser Ser
                 155                 160                 165

 ggg ttc tac cca gag gct att aat ata aca tgg gag aag cag acc cag      701
 Gly Phe Tyr Pro Glu Ala Ile Asn Ile Thr Trp Glu Lys Gln Thr Gln
             170                 175                 180

 aag ttt ccc cat ccc ata gag att tct gag gat gtc atc act ggt ccc      749
 Lys Phe Pro His Pro Ile Glu Ile Ser Glu Asp Val Ile Thr Gly Pro
         185                 190                 195

 acc atc aag aat atg gat ggc aca ttt aat gtc act agc tgc ttg aag      797
 Thr Ile Lys Asn Met Asp Gly Thr Phe Asn Val Thr Ser Cys Leu Lys
     200                 205                 210

 ctg aac tcc tct cag gaa gac cct ggg act gtc tac cag tgt gtg gta      845
 Leu Asn Ser Ser Gln Glu Asp Pro Gly Thr Val Tyr Gln Cys Val Val
 215                 220                 225                 230

 cgg cat gcg tcc ttg cat acc ccc ttg agg agc aac ttt acc ctg act      893
 Arg His Ala Ser Leu His Thr Pro Leu Arg Ser Asn Phe Thr Leu Thr
                 235                 240                 245

 gct gct cgg cac agt ctt tct gaa act gag aag aca gat aat ttt tcc      941
 Ala Ala Arg His Ser Leu Ser Glu Thr Glu Lys Thr Asp Asn Phe Ser
             250                 255                 260

 att cat tgg tgg cct att tca ttc att ggt gtt gga ctg gtt tta tta      989
 Ile His Trp Trp Pro Ile Ser Phe Ile Gly Val Gly Leu Val Leu Leu
         265                 270                 275

 att gtt ttg att cct tgg aaa aag ata tgt aac aaa tca tct tca gcc     1037
 Ile Val Leu Ile Pro Trp Lys Lys Ile Cys Asn Lys Ser Ser Ser Ala
     280                 285                 290

 tat act cct ctc aag tgc att ctg aaa cac tgg aac tcc ttt gac act     1085
 Tyr Thr Pro Leu Lys Cys Ile Leu Lys His Trp Asn Ser Phe Asp Thr
 295                 300                 305                 310

 cag act ctg aag aaa gag cac ctc ata ttc ttt tgc act cgg gca tgg     1133
 Gln Thr Leu Lys Lys Glu His Leu Ile Phe Phe Cys Thr Arg Ala Trp
                 315                 320                 325

 ccg tct tac cag ctg cag gat ggg gag gct tgg cct cct gag gga agt     1181
 Pro Ser Tyr Gln Leu Gln Asp Gly Glu Ala Trp Pro Pro Glu Gly Ser
             330                 335                 340

 gtt aat att aat act att caa caa cta gat gtt ttc tgc aga cag gag     1229
 Val Asn Ile Asn Thr Ile Gln Gln Leu Asp Val Phe Cys Arg Gln Glu
         345                 350                 355

 ggc aaa tgg tcc gag gtt cct tat gtg caa gcc ttc ttt gcc ttg cga     1277
 Gly Lys Trp Ser Glu Val Pro Tyr Val Gln Ala Phe Phe Ala Leu Arg
     360                 365                 370

 gac aac cca gat ctt tgt cag tgt tgt aga att gac cct gct ctc cta     1325
 Asp Asn Pro Asp Leu Cys Gln Cys Cys Arg Ile Asp Pro Ala Leu Leu
 375                 380                 385                 390

 aca gtt aca tca ggc aag tcc ata gat gat aat tcc aca aag tct gag     1373
 Thr Val Thr Ser Gly Lys Ser Ile Asp Asp Asn Ser Thr Lys Ser Glu
                 395                 400                 405

 aaa caa acc cct agg gaa cac tcg gat gca gtt ccg gat gcc cca atc     1421
 Lys Gln Thr Pro Arg Glu His Ser Asp Ala Val Pro Asp Ala Pro Ile
             410                 415                 420

 ctt cct gtc tcc cct atc tgg gaa cct cct cca gcc aca aca tca aca     1469
 Leu Pro Val Ser Pro Ile Trp Glu Pro Pro Pro Ala Thr Thr Ser Thr
         425                 430                 435

 act cca gtt cta tcc tcc caa ccc cca act tta ctg tta ccc cta cag     1517
 Thr Pro Val Leu Ser Ser Gln Pro Pro Thr Leu Leu Leu Pro Leu Gln
     440                 445                 450

 taa atgc ctgatggacc tggtgccact agggtccaag ttcccttttc attacaggac     1574
 






      <210> 449
      <211> 2015
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (15)..(1532)

      <400> 449
 tgaagtttta cttc  atg agc cct tgt gaa aaa tac cga gcc aga cgc cag      50
                  Met Ser Pro Cys Glu Lys Tyr Arg Ala Arg Arg Gln
                    1               5                  10

 att ccg tgg aaa ctg ggt ttg cag att ttg aag ata gtc atg gtc acc       98
 Ile Pro Trp Lys Leu Gly Leu Gln Ile Leu Lys Ile Val Met Val Thr
          15                  20                  25

 aca cag ctt gtt cgt ttt ggt tta agt aac cag ctg gtg gtt gct ttc      146
 Thr Gln Leu Val Arg Phe Gly Leu Ser Asn Gln Leu Val Val Ala Phe
      30                  35                  40

 aaa gaa gat aac act gtt gct ttt aag cac ttg ttt ttg aaa gga tat      194
 Lys Glu Asp Asn Thr Val Ala Phe Lys His Leu Phe Leu Lys Gly Tyr
  45                  50                  55                  60

 tct ggt aca gat gaa gat gac tac agc tgc agt gta tat act caa gag      242
 Ser Gly Thr Asp Glu Asp Asp Tyr Ser Cys Ser Val Tyr Thr Gln Glu
                  65                  70                  75

 gat gcc tat gag agc atc ttt ttt gct att aat cag tat cat cag cta      290
 Asp Ala Tyr Glu Ser Ile Phe Phe Ala Ile Asn Gln Tyr His Gln Leu
              80                  85                  90

 aag gac att acc ctg ggg acc ctt ggt tat gga gaa aat gaa gac aat      338
 Lys Asp Ile Thr Leu Gly Thr Leu Gly Tyr Gly Glu Asn Glu Asp Asn
          95                 100                 105

 aga att ggc tta aaa gtc tgt aag cag cat tac aag aaa ggg acc atg      386
 Arg Ile Gly Leu Lys Val Cys Lys Gln His Tyr Lys Lys Gly Thr Met
     110                 115                 120

 ttt cct tct aat gag aca ctg aat att gac aac gac gtt gag ctc gat      434
 Phe Pro Ser Asn Glu Thr Leu Asn Ile Asp Asn Asp Val Glu Leu Asp
 125                 130                 135                 140

 tgt gtt caa tta gac ctt cag gac ctc tcc aag aag cct ccg gac tgg      482
 Cys Val Gln Leu Asp Leu Gln Asp Leu Ser Lys Lys Pro Pro Asp Trp
                 145                 150                 155

 aag aac tca tca ttc ttc aga ctg gaa ttt tat cga tac gca gag atc      530
 Lys Asn Ser Ser Phe Phe Arg Leu Glu Phe Tyr Arg Tyr Ala Glu Ile
             160                 165                 170

 agg ggc ata ttt tct aag tcc aag tat agg ttg cca att ttc tgt gaa      578
 Arg Gly Ile Phe Ser Lys Ser Lys Tyr Arg Leu Pro Ile Phe Cys Glu
         175                 180                 185

 aag aaa cta acc ttt gtc aaa tat gtg att tgg aat atc att ata aag      626
 Lys Lys Leu Thr Phe Val Lys Tyr Val Ile Trp Asn Ile Ile Ile Lys
     190                 195                 200

 atc aaa atg atg gaa att tcc aag cta gtc agt caa atg cat ttc cag      674
 Ile Lys Met Met Glu Ile Ser Lys Leu Val Ser Gln Met His Phe Gln
 205                 210                 215                 220

 aac act cag aaa aat gct cag tat gtc ctg gtg ttt gat gca ttt gtc      722
 Asn Thr Gln Lys Asn Ala Gln Tyr Val Leu Val Phe Asp Ala Phe Val
                 225                 230                 235

 att gtg att tgc ttg gca tct ctt att ctg tgt aca aga tcc att gtt      770
 Ile Val Ile Cys Leu Ala Ser Leu Ile Leu Cys Thr Arg Ser Ile Val
             240                 245                 250

 ctt gct cta agg tta cgg aag aga ttt cta aat ttc ttc ctg gag aag      818
 Leu Ala Leu Arg Leu Arg Lys Arg Phe Leu Asn Phe Phe Leu Glu Lys
         255                 260                 265

 tac aag cgg cct gtg tgt gac acc gac cag tgg gag ttc atc aac ggc      866
 Tyr Lys Arg Pro Val Cys Asp Thr Asp Gln Trp Glu Phe Ile Asn Gly
     270                 275                 280

 tgg tat gtc ctg gtg att atc agc gac cta atg aca atc att ggc tcc      914
 Trp Tyr Val Leu Val Ile Ile Ser Asp Leu Met Thr Ile Ile Gly Ser
 285                 290                 295                 300

 ata tta aaa atg gaa atc aaa gca aag aat ctc aca aac tat gat ctc      962
 Ile Leu Lys Met Glu Ile Lys Ala Lys Asn Leu Thr Asn Tyr Asp Leu
                 305                 310                 315

 tgc agc att ttt ctt gga acc tct acg ctc ttg gtt tgg gtt gga gtc     1010
 Cys Ser Ile Phe Leu Gly Thr Ser Thr Leu Leu Val Trp Val Gly Val
             320                 325                 330

 atc aga tac ctg ggt tat ttc cag gca tat aat gtg ctg att tta aca     1058
 Ile Arg Tyr Leu Gly Tyr Phe Gln Ala Tyr Asn Val Leu Ile Leu Thr
         335                 340                 345

 atg cag gcc tca ctg cca aaa gtt ctt cgg ttt tgt gct tgt gct ggt     1106
 Met Gln Ala Ser Leu Pro Lys Val Leu Arg Phe Cys Ala Cys Ala Gly
     350                 355                 360

 atg att tat ctg ggt tac aca ttc tgt ggc tgg att gtc tta gga cca     1154
 Met Ile Tyr Leu Gly Tyr Thr Phe Cys Gly Trp Ile Val Leu Gly Pro
 365                 370                 375                 380

 tac cat gac aag ttt gaa aat ctg aac aca gtt gct gag tgt ctg ttt     1202
 Tyr His Asp Lys Phe Glu Asn Leu Asn Thr Val Ala Glu Cys Leu Phe
                 385                 390                 395

 tct ctg gtc aac ggt gat gac atg ttt gca acc ttt gcc caa atc cag     1250
 Ser Leu Val Asn Gly Asp Asp Met Phe Ala Thr Phe Ala Gln Ile Gln
             400                 405                 410

 cag aag agc atc ttg gtg tgg ctg ttc agt cgt ctg tat tta tat tcc     1298
 Gln Lys Ser Ile Leu Val Trp Leu Phe Ser Arg Leu Tyr Leu Tyr Ser
         415                 420                 425

 ttc atc agc ctt ttt ata tat atg att ctc agt ctt ttt att gca ctt     1346
 Phe Ile Ser Leu Phe Ile Tyr Met Ile Leu Ser Leu Phe Ile Ala Leu
     430                 435                 440

 att aca gat tct tat gac acc att aag aaa ttc caa cag aat ggg ttt     1394
 Ile Thr Asp Ser Tyr Asp Thr Ile Lys Lys Phe Gln Gln Asn Gly Phe
 445                 450                 455                 460

 cct gaa acg gat ttg cag gaa ttc ctg aag gaa tgc agt agc aaa gaa     1442
 Pro Glu Thr Asp Leu Gln Glu Phe Leu Lys Glu Cys Ser Ser Lys Glu
                 465                 470                 475

 gag tat cag aaa gag tcc tca gcc ttc ctg tcc tgc atc tgc tgt cgg     1490
 Glu Tyr Gln Lys Glu Ser Ser Ala Phe Leu Ser Cys Ile Cys Cys Arg
             480                 485                 490

 agg agg aaa aga agt gat gat cac ttg ata cct att agc taa agttctg     1539
 Arg Arg Lys Arg Ser Asp Asp His Leu Ile Pro Ile Ser 
         495                 500                 505

 ctaaagatga ttaaagttca ggcatcctta tccagcagct gagcagagga accccaaatg   1599

 acttggacaa gcagttccaa aatgactctc ttatttaatg tggagtggga aagaggactc   1659

 acagttagcc agctgaccat gactgaagtt ccagctttac ttgttataaa acttgaatga   1719

 taaagaatag accatgggct actactgggc attagtgcaa tataaccagc cgataataaa   1779

 atttctctat tagtctgtta ctttatgaca tgatctcgga atggcaaaga ttcatttcca   1839

 gaagtgtgcg aaataatagt tcttaccctg ttaattacac attgtgcgtc ctcggcccca   1899

 agggactggc acaaagggaa ctgcggtgga aaacatttgt taataccggg ctcggtcaca   1959

 aaagacccgg tggggcatcc atttaagagt cacgggcgaa ctacacgggc aagacc       2015




      <210> 450
      <211> 797
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (138)..(449)

      <400> 450
 cagcccgggt tagtaaactt gggtccttta aaacgggccc cccttttttt tttttttctc     60

 ttcttcataa gtttgtctag ttttgatctt tgaggctgtt gatccttgga tgaggatttg    120

 tggggacttt tttgttg   atg cta ttg ttg ttg ctt tct gtt tgt ttg ttt     170
                      Met Leu Leu Leu Leu Leu Ser Val Cys Leu Phe
                        1               5                  10

 gtt tgt ttt tta ata gtc agc tcc ctc ttc tct agg gct gct gtg gtt      218
 Val Cys Phe Leu Ile Val Ser Ser Leu Phe Ser Arg Ala Ala Val Val
              15                  20                  25

 tgc tgg gag ttc act tca ggc cct att cat cag gtt cac tcc cgt gcc      266
 Cys Trp Glu Phe Thr Ser Gly Pro Ile His Gln Val His Ser Arg Ala
          30                  35                  40

 tgg aga tgt cac tcg agg aga ctg gag aac agc aaa gat gga tgc ctg      314
 Trp Arg Cys His Ser Arg Arg Leu Glu Asn Ser Lys Asp Gly Cys Leu
      45                  50                  55

 ctc ctt cct ctg gga tct ctg acc tcg agg ggc acc aac ctg atg cta      362
 Leu Leu Pro Leu Gly Ser Leu Thr Ser Arg Gly Thr Asn Leu Met Leu
  60                  65                  70                  75

 gta gga ttg ttc ctg tat tgg gtg tct gac aac ccc tgt tgg agg gtc      410
 Val Gly Leu Phe Leu Tyr Trp Val Ser Asp Asn Pro Cys Trp Arg Val
                  80                  85                  90

 tca ccc agt tgg gtg gca tgg gga gca gga ccc att taa tgaagcactt       459
 Ser Pro Ser Trp Val Ala Trp Gly Ala Gly Pro Ile 
              95                 100

 tgtcccttgg tggagagggt atgtttcgct ggggagaaac ccactcatct gggctggatt    519

 cctcagaact actgggaaga gaggctaagt ctgctagtct gcagagactg tgggtacgcc    579

 tccacctagg ggatcaggcc taaggagatc agaattctgt ccctgagcct ctgactggag    639

 ttattggaga tcctgcaggg aaaccctgct cactgaggaa atatgggtca gggttagtta    699

 gacctgaaga ggcactgtgg tggcagactg cacagctggt gtgttgggca aggggacaag    759

 tcttgggacc aagccatcca gtctccctgg ctcgtgcc                            797




      <210> 451
      <211> 723
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (155)..(397)

      <400> 451
 catttttttt ttctctaaat aagtgggggt aatacctata ttagaggatt atgataaaaa     60

 gatgtgaaca tattataaaa ttattttata aactagaaga catttcaaag aagttaagct    120

 gccactgtta gtttcacaga cttgggtgta ttag    atg aac agc ttt tca gtt     172
                                          Met Asn Ser Phe Ser Val
                                            1               5

 att gct tct ata gtt gtc ctc ttg ccc ttt cct gga tta tca gtt tct      220
 Ile Ala Ser Ile Val Val Leu Leu Pro Phe Pro Gly Leu Ser Val Ser
              10                  15                  20

 gcc tgt cta cct agt cat tcc cat cag tgt aaa aca ttt ata ctg tta      268
 Ala Cys Leu Pro Ser His Ser His Gln Cys Lys Thr Phe Ile Leu Leu
          25                  30                  35

 ttt ctt cca agt tca gaa aaa acc ctc tct cga ctc ccc cca tcc cat      316
 Phe Leu Pro Ser Ser Glu Lys Thr Leu Ser Arg Leu Pro Pro Ser His
      40                  45                  50

 tct agc aca tac acc ctg att tct ctg ctt ccc ttt ata aat aga att      364
 Ser Ser Thr Tyr Thr Leu Ile Ser Leu Leu Pro Phe Ile Asn Arg Ile
  55                  60                  65                  70

 gct gga aga att gtc tgt gtc tct ttt ctt taa ctcttctc ctcccattct      415
 Ala Gly Arg Ile Val Cys Val Ser Phe Leu 
                  75                  80

 ctcttaaatt cactgcagtg atcctttcct ccgaccattc attcctctga aatagctttt    475

 gcaagtcacc agtgatgtct gttgaatgtt ttacttgacc taacagcaag gtttgattca    535

 attaattact cccactacct tgatatactt ttttcacttg gcattcagga tatctcactc    595

 ggtttttttt tttttttttt ttaaccaacc cggggggttt tttctcatcc ccctcggggg    655

 aggggttttc cttttcggaa tctttaaaat tgggaagggc ccaggcccca tttcccaaat    715

 tgtttatt                                                             723




      <210> 452
      <211> 4322
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (366)..(3404)

      <400> 452
 cagaattctc aaagctgacg gatcggtggc agaatgctgt ccagggtgtt cggcagagga     60

 agggtgacgt tgatgggctg gtgaggcagt ggcaagattt cactacttct gtggagaact    120

 tgtttcgctt cctcactgac accagccacc tgctatctgc agtgaagggc caggagcgct    180

 tcagcctata ccaaaccaga agtctgatcc atgagctgaa gaataaagaa attcattttc    240

 aaaggaggcg aactacctgt gccctaacct tggaagctgg agaaaagtta ctgctcacaa    300

 ctgacctgaa aactaaagag tctgtgggta ggagaatcag tcaacttcag gacagctgga    360

 aagac    atg gag ccc cag ctg gca gag atg att aag cag ttc cag agc     407
          Met Glu Pro Gln Leu Ala Glu Met Ile Lys Gln Phe Gln Ser
            1               5                  10

 act gta gag acc tgg gac cag tgt gaa aag aaa atc aag gag ttg aaa      455
 Thr Val Glu Thr Trp Asp Gln Cys Glu Lys Lys Ile Lys Glu Leu Lys
  15                  20                  25                  30

 agc agg ctg caa gtt tta aag gca caa agt gaa gat cct ctt cca gag      503
 Ser Arg Leu Gln Val Leu Lys Ala Gln Ser Glu Asp Pro Leu Pro Glu
                  35                  40                  45

 ctt cac gag gac ctc cat aac gaa aaa gag ctg att aag gaa cta gaa      551
 Leu His Glu Asp Leu His Asn Glu Lys Glu Leu Ile Lys Glu Leu Glu
              50                  55                  60

 cag tct ttg gct agc tgg act cag aac ttg aaa gaa ctt caa act atg      599
 Gln Ser Leu Ala Ser Trp Thr Gln Asn Leu Lys Glu Leu Gln Thr Met
          65                  70                  75

 aag gcg gac tta acc cgg cac gtt ctc gtg gaa gat gtg atg gtt ttg      647
 Lys Ala Asp Leu Thr Arg His Val Leu Val Glu Asp Val Met Val Leu
      80                  85                  90

 aag gag caa ata gag cat ttg cac aga caa tgg gag gac ctc tgc tta      695
 Lys Glu Gln Ile Glu His Leu His Arg Gln Trp Glu Asp Leu Cys Leu
  95                 100                 105                 110

 agg gtg gcc ata cgt aaa cag gag att gaa gac aga ctc aat aca tgg      743
 Arg Val Ala Ile Arg Lys Gln Glu Ile Glu Asp Arg Leu Asn Thr Trp
                 115                 120                 125

 gtt gta ttc aat gaa aaa aat aaa gag ttg tgt gcc tgg ctg gtg cag      791
 Val Val Phe Asn Glu Lys Asn Lys Glu Leu Cys Ala Trp Leu Val Gln
             130                 135                 140

 atg gaa aac aaa gtt cta cag aca gcg gac att agt att gaa gaa atg      839
 Met Glu Asn Lys Val Leu Gln Thr Ala Asp Ile Ser Ile Glu Glu Met
         145                 150                 155

 att gaa aag tta cag aag gac tgc atg gaa gaa ata aac ttg ttt agt      887
 Ile Glu Lys Leu Gln Lys Asp Cys Met Glu Glu Ile Asn Leu Phe Ser
     160                 165                 170

 gaa aac aag tta cag tta aag cag atg ggt gac cag ttg atc aag gcc      935
 Glu Asn Lys Leu Gln Leu Lys Gln Met Gly Asp Gln Leu Ile Lys Ala
 175                 180                 185                 190

 agc aac aaa tca aga gca gct gag atc gat gac aag ctc aac aaa att      983
 Ser Asn Lys Ser Arg Ala Ala Glu Ile Asp Asp Lys Leu Asn Lys Ile
                 195                 200                 205

 aac gat cgt tgg caa cat ctt ttt gat gtc atc gga tca agg gtg aag     1031
 Asn Asp Arg Trp Gln His Leu Phe Asp Val Ile Gly Ser Arg Val Lys
             210                 215                 220

 aag ctg aag gag acc ttt gct ttt att cag cag ttg gac aaa aac atg     1079
 Lys Leu Lys Glu Thr Phe Ala Phe Ile Gln Gln Leu Asp Lys Asn Met
         225                 230                 235

 agc aac ctt cgc acc tgg ttg gct cga att gag tct gag ctt tcc aag     1127
 Ser Asn Leu Arg Thr Trp Leu Ala Arg Ile Glu Ser Glu Leu Ser Lys
     240                 245                 250

 cct gtt gtt tat gat gtc tgc gat gat caa gag atc cag aag agg ctc     1175
 Pro Val Val Tyr Asp Val Cys Asp Asp Gln Glu Ile Gln Lys Arg Leu
 255                 260                 265                 270

 gct gag cag cag gat cta cag cga gat att gaa caa cac agc gca ggg     1223
 Ala Glu Gln Gln Asp Leu Gln Arg Asp Ile Glu Gln His Ser Ala Gly
                 275                 280                 285

 gtg gag tcc gtg ttt aac atc tgt gac gtc cta ctg cac gac tcc gat     1271
 Val Glu Ser Val Phe Asn Ile Cys Asp Val Leu Leu His Asp Ser Asp
             290                 295                 300

 gcc tgt gca aat gag acc gag tgt gac tcg atc cag cag acc acc agg     1319
 Ala Cys Ala Asn Glu Thr Glu Cys Asp Ser Ile Gln Gln Thr Thr Arg
         305                 310                 315

 agc ctg gac aga cgc tgg agg aac att tgt gcc atg tcc atg gag cgg     1367
 Ser Leu Asp Arg Arg Trp Arg Asn Ile Cys Ala Met Ser Met Glu Arg
     320                 325                 330

 cgc atg aaa atc gag gag acg tgg cgc ctg tgg cag aag ttt tta gac     1415
 Arg Met Lys Ile Glu Glu Thr Trp Arg Leu Trp Gln Lys Phe Leu Asp
 335                 340                 345                 350

 gac tat tct cgc ttt gag gac tgg ctc aag tca gcc gtc ctg cgg aga     1463
 Asp Tyr Ser Arg Phe Glu Asp Trp Leu Lys Ser Ala Val Leu Arg Arg
                 355                 360                 365

 ctc agg cat ttc acc aac cag agg gaa gaa ttt gag ggc acc agg gag     1511
 Leu Arg His Phe Thr Asn Gln Arg Glu Glu Phe Glu Gly Thr Arg Glu
             370                 375                 380

 agc att ctg gtg tgg ctc aca gag atg gac ctg cag ctg acc aac gtg     1559
 Ser Ile Leu Val Trp Leu Thr Glu Met Asp Leu Gln Leu Thr Asn Val
         385                 390                 395

 gag cac ttc tca gag agt gac gcc gat gac aag atg cgc caa ctg aat     1607
 Glu His Phe Ser Glu Ser Asp Ala Asp Asp Lys Met Arg Gln Leu Asn
     400                 405                 410

 ggc ttc caa cag gaa att aca tta aat acc aac aag att gat cag ctc     1655
 Gly Phe Gln Gln Glu Ile Thr Leu Asn Thr Asn Lys Ile Asp Gln Leu
 415                 420                 425                 430

 att gtg ttt ggg gag cag ctg att cag aag agc gag ccc ctg gat gct     1703
 Ile Val Phe Gly Glu Gln Leu Ile Gln Lys Ser Glu Pro Leu Asp Ala
                 435                 440                 445

 gtg ctg att gag gat gag ctg gag gaa ctc cac cgc tac tgc cag gag     1751
 Val Leu Ile Glu Asp Glu Leu Glu Glu Leu His Arg Tyr Cys Gln Glu
             450                 455                 460

 gtg ttt gga agg gtc tcc cgg ttc cac cgg cgg ctc acc tcc tgc act     1799
 Val Phe Gly Arg Val Ser Arg Phe His Arg Arg Leu Thr Ser Cys Thr
         465                 470                 475

 ccg ggc ttg gaa gat gaa aag gag gcc tct gag aat gaa aca gac atg     1847
 Pro Gly Leu Glu Asp Glu Lys Glu Ala Ser Glu Asn Glu Thr Asp Met
     480                 485                 490

 gaa gac ccc aga gaa atc cag act gat tct tgg cgt aaa cgg gga gag     1895
 Glu Asp Pro Arg Glu Ile Gln Thr Asp Ser Trp Arg Lys Arg Gly Glu
 495                 500                 505                 510

 agc gag gaa ccg tca tct cct cag tcc ctg tgt cat cta gtg gcc cca     1943
 Ser Glu Glu Pro Ser Ser Pro Gln Ser Leu Cys His Leu Val Ala Pro
                 515                 520                 525

 ggg cac gag cgg tct ggc tgc gag acc cct gtc agc gtg gac tcc atc     1991
 Gly His Glu Arg Ser Gly Cys Glu Thr Pro Val Ser Val Asp Ser Ile
             530                 535                 540

 ccc ctg gag tgg gac cac aca ggc gac gtg ggg ggc tcc tcc tct cac     2039
 Pro Leu Glu Trp Asp His Thr Gly Asp Val Gly Gly Ser Ser Ser His
         545                 550                 555

 gaa gag gac gag gag ggc cca tac tac agc gca ctg tca ggt aaa tcc     2087
 Glu Glu Asp Glu Glu Gly Pro Tyr Tyr Ser Ala Leu Ser Gly Lys Ser
     560                 565                 570

 att tcg gat ggc cac tcg tgg cat gtt ccc gac agc cct tcc tgt ccc     2135
 Ile Ser Asp Gly His Ser Trp His Val Pro Asp Ser Pro Ser Cys Pro
 575                 580                 585                 590

 gag cat cac tac aag caa atg gaa ggt gac agg aat gtt cca cct gtt     2183
 Glu His His Tyr Lys Gln Met Glu Gly Asp Arg Asn Val Pro Pro Val
                 595                 600                 605

 ccc cct gcg tcc agc acc cct tat aaa cca ccc tat gga aag cta cta     2231
 Pro Pro Ala Ser Ser Thr Pro Tyr Lys Pro Pro Tyr Gly Lys Leu Leu
             610                 615                 620

 tta cct cca ggc acg gat ggt ggc aaa gaa ggc ccg cga gtc ctg aat     2279
 Leu Pro Pro Gly Thr Asp Gly Gly Lys Glu Gly Pro Arg Val Leu Asn
         625                 630                 635

 ggc aac cca cag cag gaa gac ggg gga ctg gcc ggt atc aca gag cag     2327
 Gly Asn Pro Gln Gln Glu Asp Gly Gly Leu Ala Gly Ile Thr Glu Gln
     640                 645                 650

 cag tca ggt gcc ttc gac aga tgg gag atg att caa gca cag gag ctt     2375
 Gln Ser Gly Ala Phe Asp Arg Trp Glu Met Ile Gln Ala Gln Glu Leu
 655                 660                 665                 670

 cac aat aag ctc aaa ata aaa caa aat ttg caa cag ctg aac tct gat     2423
 His Asn Lys Leu Lys Ile Lys Gln Asn Leu Gln Gln Leu Asn Ser Asp
                 675                 680                 685

 atc agc gcc atc act act tgg ctg aaa aaa act gaa gca gag ctg gaa     2471
 Ile Ser Ala Ile Thr Thr Trp Leu Lys Lys Thr Glu Ala Glu Leu Glu
             690                 695                 700

 atg tta aag atg gca aag cct ccc tct gat atc cag gaa ata gaa ctg     2519
 Met Leu Lys Met Ala Lys Pro Pro Ser Asp Ile Gln Glu Ile Glu Leu
         705                 710                 715

 aga gtg aag aga ctg cag gag ata ctg aaa gcc ttt gac act tac aag     2567
 Arg Val Lys Arg Leu Gln Glu Ile Leu Lys Ala Phe Asp Thr Tyr Lys
     720                 725                 730

 gca tta gtg gtc tct gtc aac gtg agc agc aag gaa ttt ctg caa acc     2615
 Ala Leu Val Val Ser Val Asn Val Ser Ser Lys Glu Phe Leu Gln Thr
 735                 740                 745                 750

 gag agc ccc gaa tcc aca gag ctc caa agt aga ctc cgc cag ctg agc     2663
 Glu Ser Pro Glu Ser Thr Glu Leu Gln Ser Arg Leu Arg Gln Leu Ser
                 755                 760                 765

 ctg ctc tgg gaa gca gca cag ggc gca gtg gac agc tgg aga ggg ggc     2711
 Leu Leu Trp Glu Ala Ala Gln Gly Ala Val Asp Ser Trp Arg Gly Gly
             770                 775                 780

 tta cga cag tcg ctc atg cag tgc cag gac ttc cac cag ttg agt caa     2759
 Leu Arg Gln Ser Leu Met Gln Cys Gln Asp Phe His Gln Leu Ser Gln
         785                 790                 795

 aat ctg ctg ctg tgg tta gcg agt gcc aag aac cgg agg cag aag gct     2807
 Asn Leu Leu Leu Trp Leu Ala Ser Ala Lys Asn Arg Arg Gln Lys Ala
     800                 805                 810

 cat gtc acc gat cca aag gca gac ccc cgg gct ctc cta gag tgt cgg     2855
 His Val Thr Asp Pro Lys Ala Asp Pro Arg Ala Leu Leu Glu Cys Arg
 815                 820                 825                 830

 agg gaa cta atg caa ctg gaa aag gag ctg gta gaa cgt caa cct caa     2903
 Arg Glu Leu Met Gln Leu Glu Lys Glu Leu Val Glu Arg Gln Pro Gln
                 835                 840                 845

 gtg gac atg tta cag gag att tca aac agc ctt ctc att aag gga cat     2951
 Val Asp Met Leu Gln Glu Ile Ser Asn Ser Leu Leu Ile Lys Gly His
             850                 855                 860

 gga gaa gac tgt att gaa gct gaa gaa aag gtg cat gtt att gag aag     2999
 Gly Glu Asp Cys Ile Glu Ala Glu Glu Lys Val His Val Ile Glu Lys
         865                 870                 875

 aaa ctc aaa cag tta cgg gag caa gtg tcc caa gat tta atg gcc ttg     3047
 Lys Leu Lys Gln Leu Arg Glu Gln Val Ser Gln Asp Leu Met Ala Leu
     880                 885                 890

 cag gga acc cag aac cca gcc tca ccc ctg ccc agc ttc gac gag gta     3095
 Gln Gly Thr Gln Asn Pro Ala Ser Pro Leu Pro Ser Phe Asp Glu Val
 895                 900                 905                 910

 gac tcg ggg gac cag cct cct gca aca tcc gtg cca gct ccc cga gca     3143
 Asp Ser Gly Asp Gln Pro Pro Ala Thr Ser Val Pro Ala Pro Arg Ala
                 915                 920                 925

 aag cag ttc aga gca gtg aga act aca gaa ggc gag gag gag aca gag     3191
 Lys Gln Phe Arg Ala Val Arg Thr Thr Glu Gly Glu Glu Glu Thr Glu
             930                 935                 940

 agc agg gtc ccc ggc agc aca cgg cca cag cgc tcc ttc ctc tca agg     3239
 Ser Arg Val Pro Gly Ser Thr Arg Pro Gln Arg Ser Phe Leu Ser Arg
         945                 950                 955

 gtg gtc cgg gca gcc cta ccc ctg cag ctg ctc ctc ctg ctg ctg ctg     3287
 Val Val Arg Ala Ala Leu Pro Leu Gln Leu Leu Leu Leu Leu Leu Leu
     960                 965                 970

 ctc ctg gcc tgc ctg ctg ccc tcc tcc gaa gaa gac tac agc tgc act     3335
 Leu Leu Ala Cys Leu Leu Pro Ser Ser Glu Glu Asp Tyr Ser Cys Thr
 975                 980                 985                 990

 cag gcc aac aac ttt gcc cgg tcc ttt tac ccc atg ctg agg tac acc     3383
 Gln Ala Asn Asn Phe Ala Arg Ser Phe Tyr Pro Met Leu Arg Tyr Thr
                 995                1000                1005

 aat ggg cca ccc ccc aca tag ag ggcatagctg gccacagtgc tacaccacct     3436
 Asn Gly Pro Pro Pro Thr 
            1010

 gcctgattgc caagggtgcc cagcacgtgg ccccagacca atctgagtga cttagtgttg   3496

 gcaaggtccc gggacctgtg cagacttctt ctgggcttac acagcacggg ctccctggag   3556

 cccagggcag ctttcagatt gtgttcctcc ccaggagcag ggaacctgtg tggcaggtgc   3616

 cccgggtact ttggcagaac tagttgatta gtttagggat ctctggaaat gtcagtttcc   3676

 tgaagagcca agcactttgt gaattctggt ttgtttgtaa aacagcatta ttataatgta   3736

 ggtatggtca atgagcagtg gtgtccatca catatattat agaagcaagc gagcacattc   3796

 caccctagaa atggttcaga aactcatagg cacccttagc tgatggaaac aatcaatcat   3856

 atttaatacg cttagaatca gttttactcc aatcagctgg caattttgag ctgccggtta   3916

 tacaccaaaa tgttctgttc agtacctagc tctgctcttt tatattgctt taaattttta   3976

 aagaaattat attgcatgga tgtggttatt tgtgcatatt ttttaacaat gcccaatctg   4036

 tatgaataat gtaaacttcg attttttttt aaaaaaatta gattttagct ggagcttttg   4096

 actaatgtaa agtaaatgcc aaactaccga cttgataggg atgtttttgt aagttaattt   4156

 tctaagactt tttcacatcc aaagtgatgc tttgctttgg gttttaactg tttggccacg   4216

 gcgggggtgg gggcgggggg ttggtacaaa aacttgaagc tgtttgtgat atgtacaact   4276

 cagatgtttc tcattaaaaa acaaaattag ccagaaaaaa aaaaaa                  4322




      <210> 453
      <211> 395
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (12)..(341)

      <400> 453
 cccgcacctg c atg agt gag cgc cat ggt cct tct cca cag agc gtc ctg      50
              Met Ser Glu Arg His Gly Pro Ser Pro Gln Ser Val Leu
                1               5                  10

 ctg tca ctt tgg ttt gtg tta act ttg acg cct ttc ttg ttt ctt act       98
 Leu Ser Leu Trp Phe Val Leu Thr Leu Thr Pro Phe Leu Phe Leu Thr
      15                  20                  25

 ctg ctt tcc tgc atg gag cac aca gcc ccg gct ccc ttt cag tct gca      146
 Leu Leu Ser Cys Met Glu His Thr Ala Pro Ala Pro Phe Gln Ser Ala
  30                  35                  40                  45

 tgg cag aca cct ggc ctc tgc agg tcc agt tca ttc tgt gtc ccc ttt      194
 Trp Gln Thr Pro Gly Leu Cys Arg Ser Ser Ser Phe Cys Val Pro Phe
                  50                  55                  60

 cgg tcg tcc cta tgt tgc cgt cag gtg att gag ggt gaa ggt cgg cct      242
 Arg Ser Ser Leu Cys Cys Arg Gln Val Ile Glu Gly Glu Gly Arg Pro
              65                  70                  75

 tgg cag ccc agt gga aag tcc ctt gac tcc tgg ccg tca gtg gca ggt      290
 Trp Gln Pro Ser Gly Lys Ser Leu Asp Ser Trp Pro Ser Val Ala Gly
          80                  85                  90

 ctc cag cct ttg gga gga gga aac ttc tat tta aca aag aaa tgg aat      338
 Leu Gln Pro Leu Gly Gly Gly Asn Phe Tyr Leu Thr Lys Lys Trp Asn
      95                 100                 105

 tga cttt gccacacaca gccagagcga tgatttgtag agccaacctg ctgagacatt      395
 






      <210> 454
      <211> 386
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (104)..(376)

      <400> 454
 ttagaacacg tccaatagat ttagagacag tctaagtgac tgtgaaatgc ctcaagggca     60

 gtagaaatca aatagaaaca catactaact caagtcttga gtg  atg atg gag gcg     115
                                                  Met Met Glu Ala
                                                    1

 cat ttt aaa tac cat gga aat ctc act ggg cgt gcc cat ttt ccc act      163
 His Phe Lys Tyr His Gly Asn Leu Thr Gly Arg Ala His Phe Pro Thr
   5                  10                  15                  20

 ctg gca aca gag gtt gat acc tct tca gac aag tat tcc aac ctg tac      211
 Leu Ala Thr Glu Val Asp Thr Ser Ser Asp Lys Tyr Ser Asn Leu Tyr
                  25                  30                  35

 atg tat gtg ggc tta ttc ctg agc ctc ctg gcc att ctc ctc atc ctg      259
 Met Tyr Val Gly Leu Phe Leu Ser Leu Leu Ala Ile Leu Leu Ile Leu
              40                  45                  50

 ctc ttc aca atg ctc ctt cgg ctc aaa cat gtc atc tcg ccc atc aac      307
 Leu Phe Thr Met Leu Leu Arg Leu Lys His Val Ile Ser Pro Ile Asn
          55                  60                  65

 tct gac agc aca gaa agt gtt cct cag ttc aca gat gta gag atg cag      355
 Ser Asp Ser Thr Glu Ser Val Pro Gln Phe Thr Asp Val Glu Met Gln
      70                  75                  80

 agt cga atc ccc act ccc taa agccaggatg                               386
 Ser Arg Ile Pro Thr Pro 
  85                  90





      <210> 455
      <211> 1319
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (88)..(1269)

      <400> 455
 atactgcaag gacaaaatca ctgggacttg gcagtctcca gcagtctgaa aggctgggga     60

 attcaaacgg agaggaggaa gctgggg    atg tcc aag gga atg tgc cca tgc     111
                                  Met Ser Lys Gly Met Cys Pro Cys
                                    1               5

 atc tgc ctg gca gtg gcc ggg ctt gga gta gaa gct gag tgc acc atg      159
 Ile Cys Leu Ala Val Ala Gly Leu Gly Val Glu Ala Glu Cys Thr Met
      10                  15                  20

 atc act gcc aag tgc cgg cat caa gca ttt ggt ttc tac acc agc ttc      207
 Ile Thr Ala Lys Cys Arg His Gln Ala Phe Gly Phe Tyr Thr Ser Phe
  25                  30                  35                  40

 acg cag agg aca agg gcc agc cat ttt ctg gtg gaa gaa aag gac ccg      255
 Thr Gln Arg Thr Arg Ala Ser His Phe Leu Val Glu Glu Lys Asp Pro
                  45                  50                  55

 cgg agc cgg tcc ccg agc gcg gga gcg ggc cgc ccg cgc cgc ccc acc      303
 Arg Ser Arg Ser Pro Ser Ala Gly Ala Gly Arg Pro Arg Arg Pro Thr
              60                  65                  70

 att acc tcc ccg ggc ggc aag gag gag ctg gtg gcg gtc gcc tcc cgg      351
 Ile Thr Ser Pro Gly Gly Lys Glu Glu Leu Val Ala Val Ala Ser Arg
          75                  80                  85

 ctg tgg cag cgg cgg cgg cgt gcc tgc ctg gcg gcc gtc ggc gta ctc      399
 Leu Trp Gln Arg Arg Arg Arg Ala Cys Leu Ala Ala Val Gly Val Leu
      90                  95                 100

 ttg gcc atg gcg ctc ggg ctg ctc atc gcc gtg ccg ctg ctg ctg cag      447
 Leu Ala Met Ala Leu Gly Leu Leu Ile Ala Val Pro Leu Leu Leu Gln
 105                 110                 115                 120

 gcg gcg ccc cga ggc gcc gcg cac tat gag atg atg ggc acc tgc cgc      495
 Ala Ala Pro Arg Gly Ala Ala His Tyr Glu Met Met Gly Thr Cys Arg
                 125                 130                 135

 atg atc tgc gac cct tac act gcc gcg ccc ggc ggg gag ccc ccg ggt      543
 Met Ile Cys Asp Pro Tyr Thr Ala Ala Pro Gly Gly Glu Pro Pro Gly
             140                 145                 150

 gca aag gcg cag cca ccc gga ccc agc acc gcc gcc ctg gaa gtc atg      591
 Ala Lys Ala Gln Pro Pro Gly Pro Ser Thr Ala Ala Leu Glu Val Met
         155                 160                 165

 cag gac ctc agc gcc aac cct cct cct cct ttc atc cag gga ccc aag      639
 Gln Asp Leu Ser Ala Asn Pro Pro Pro Pro Phe Ile Gln Gly Pro Lys
     170                 175                 180

 ggc gac ccg ggg cga ccg ggc aag cca ggg ccg cgg ggg acc act gga      687
 Gly Asp Pro Gly Arg Pro Gly Lys Pro Gly Pro Arg Gly Thr Thr Gly
 185                 190                 195                 200

 gag ccg ggc ccg cct gga ccc agg ggc cct ccg gga gag aag ggc gac      735
 Glu Pro Gly Pro Pro Gly Pro Arg Gly Pro Pro Gly Glu Lys Gly Asp
                 205                 210                 215

 tcg ggg cgg ccc ggg ctg cca ggc ctg cgt ctg acg gcg ggc tcg gcc      783
 Ser Gly Arg Pro Gly Leu Pro Gly Leu Arg Leu Thr Ala Gly Ser Ala
             220                 225                 230

 agc ggc gtc ggg gtg gtg gcg cgc ggg gcc ggg gta ggt ggc gat tcc      831
 Ser Gly Val Gly Val Val Ala Arg Gly Ala Gly Val Gly Gly Asp Ser
         235                 240                 245

 gag ggt gaa gtg acc agt gcg ctg agc gcc acc ttc agc ggc ccc aag      879
 Glu Gly Glu Val Thr Ser Ala Leu Ser Ala Thr Phe Ser Gly Pro Lys
     250                 255                 260

 atc gcc ttc tat gtg ggt ctc aag agc ccc cac gaa ggc tat gag gtg      927
 Ile Ala Phe Tyr Val Gly Leu Lys Ser Pro His Glu Gly Tyr Glu Val
 265                 270                 275                 280

 ctg aag ttc gat gac gtg gtc acc aac ctc ggc aat cac tat gac ccc      975
 Leu Lys Phe Asp Asp Val Val Thr Asn Leu Gly Asn His Tyr Asp Pro
                 285                 290                 295

 acc acg ggc aag ttc agc tgc cag gta cgc ggc atc tac ttc ttc acc     1023
 Thr Thr Gly Lys Phe Ser Cys Gln Val Arg Gly Ile Tyr Phe Phe Thr
             300                 305                 310

 tac cac atc ctc atg cgc ggc ggc gac ggc acc agc atg tgg gcg gac     1071
 Tyr His Ile Leu Met Arg Gly Gly Asp Gly Thr Ser Met Trp Ala Asp
         315                 320                 325

 ctc tgc aag aac ggg cag gtc cgg gcc agc gcc att gca cag gac gcc     1119
 Leu Cys Lys Asn Gly Gln Val Arg Ala Ser Ala Ile Ala Gln Asp Ala
     330                 335                 340

 gac cag aac tac gac tac gcc agt aac agc gtg gtg ctg cac ttg gat     1167
 Asp Gln Asn Tyr Asp Tyr Ala Ser Asn Ser Val Val Leu His Leu Asp
 345                 350                 355                 360

 tca ggg gac gaa gtg tat gtg aag ctg gat ggc ggg aag gct cac gga     1215
 Ser Gly Asp Glu Val Tyr Val Lys Leu Asp Gly Gly Lys Ala His Gly
                 365                 370                 375

 ggc aat aat aac aag tac agc acg ttc tcg ggc ttt ctt ctg tac ccg     1263
 Gly Asn Asn Asn Lys Tyr Ser Thr Phe Ser Gly Phe Leu Leu Tyr Pro
             380                 385                 390

 gat tag gggcgcgggg ggtgcgaggc ggggtggctg cagccgcccg gtctccgccc      1319
 Asp 






      <210> 456
      <211> 977
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (260)..(658)

      <400> 456
 ggcttcctgt atacatgtga taatgatact gttttaaaga acaggtgtga aagtctaaga     60

 gtttaatcca gactctgcac aagaagttaa tctgccaaac cctaggattc tccttctgaa    120

 agctcagaat atttcttccc cttccctata cacacagggc tcgaagggtt agagaagaaa    180

 ggcagacaac agcttctgag ctttggacta atcacagcct ctgttctcag caggagcccc    240

 aacactgaga ccagaaaag atg gtg cta tgc ttt cct ctt ctt tta ctg ctg     292
                      Met Val Leu Cys Phe Pro Leu Leu Leu Leu Leu
                        1               5                  10

 ctg gtt cta tgg gga cca gtg tgt cca ctt cat gct tgg cct aag cgt      340
 Leu Val Leu Trp Gly Pro Val Cys Pro Leu His Ala Trp Pro Lys Arg
              15                  20                  25

 ctc acc aag gct cac tgg ttt gaa att cag cat ata cag cca agt cct      388
 Leu Thr Lys Ala His Trp Phe Glu Ile Gln His Ile Gln Pro Ser Pro
          30                  35                  40

 ctc caa tgc aac agg gca atg agt ggc atc aac aat tat acc cag cac      436
 Leu Gln Cys Asn Arg Ala Met Ser Gly Ile Asn Asn Tyr Thr Gln His
      45                  50                  55

 tgt aag cat caa aat acc ttt ctg cat gac tct ttc cag aat gtg gct      484
 Cys Lys His Gln Asn Thr Phe Leu His Asp Ser Phe Gln Asn Val Ala
  60                  65                  70                  75

 gct gtc tgt gat ttg ctc agc att gtc tgc agc aga ctc act tca gga      532
 Ala Val Cys Asp Leu Leu Ser Ile Val Cys Ser Arg Leu Thr Ser Gly
                  80                  85                  90

 aag tat ccc cag tgc cgc tat agt gct gct gcc cag tac aaa ttc ttc      580
 Lys Tyr Pro Gln Cys Arg Tyr Ser Ala Ala Ala Gln Tyr Lys Phe Phe
              95                 100                 105

 att gtt gcc tgt gac ccc cct cag aag agc gat ccc ccc tac aag ttg      628
 Ile Val Ala Cys Asp Pro Pro Gln Lys Ser Asp Pro Pro Tyr Lys Leu
         110                 115                 120

 gtt cct gta cac tta gat agt att ctc taa g gcatccactg catttccttt      679
 Val Pro Val His Leu Asp Ser Ile Leu 
     125                 130

 catttgacat agcttctgtt acaattgcat ccacgttttc ttttcttttg ttgattttct    739

 tgttcccgta gaagaaagaa gaaaggtgtt tggagaattc gagtgcctag gatgccagac    799

 cagagttgag acaaaaagaa ataagattat tttctgcttt gtagttctgt acttttcgag    859

 agaagggaat agggaagaca gcaaagaaag attcagattt ctaaccctgc aacttttgcc    919

 aagctttatt gccctgtgtt cacagcaata aaaccacttc ctgctgcaaa aaaaaaaa      977




      <210> 457
      <211> 727
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (236)..(673)

      <400> 457
 atgacccagg atcatgacaa acccaaagaa caaaccctaa atccaagctt tcacaagagc     60

 tacagaacct gccagcaata cacggacttc acggtgaatg ctgacagtca caagcgcgtg    120

 gtcttcccgc tttccacccc ccgacgtgcc cccgcgctgg tcctgcccct gcccacgagg    180

 gtcggcgcgc cgtgtgtctc ccggtgtcta gagtccgcgg cgtgcaccaa acatc atg     238
                                                              Met
                                                                1

 aac cat gcg tgc ctc ccc gac ttc acg gta cgg gcg cgc agc caa tgg      286
 Asn His Ala Cys Leu Pro Asp Phe Thr Val Arg Ala Arg Ser Gln Trp
               5                  10                  15

 acg cga tac ccg gcc tcc ccg gag ccc aga gct cgc agc tcc gcc ggc      334
 Thr Arg Tyr Pro Ala Ser Pro Glu Pro Arg Ala Arg Ser Ser Ala Gly
          20                  25                  30

 gcc tgg tcc cag cgc ccg cgg cgc cgc gtc ccc ggc cca acc atg gcg      382
 Ala Trp Ser Gln Arg Pro Arg Arg Arg Val Pro Gly Pro Thr Met Ala
      35                  40                  45

 tcc tcc gcg gcc ggc tgc gtg gtg atc gtt ggc agt gga gtc att ggg      430
 Ser Ser Ala Ala Gly Cys Val Val Ile Val Gly Ser Gly Val Ile Gly
  50                  55                  60                  65

 cga agc tgg gcc atg ctg ttt gcc agt gga ggc ttc cag gtg aaa ctc      478
 Arg Ser Trp Ala Met Leu Phe Ala Ser Gly Gly Phe Gln Val Lys Leu
                  70                  75                  80

 tat gac att gag caa cag cag ata agg aat gcc ctg gaa aac atc ata      526
 Tyr Asp Ile Glu Gln Gln Gln Ile Arg Asn Ala Leu Glu Asn Ile Ile
              85                  90                  95

 aag gag atg aag ttg ctg gag cag gca ggt tct ctg aaa ggc tcc ctg      574
 Lys Glu Met Lys Leu Leu Glu Gln Ala Gly Ser Leu Lys Gly Ser Leu
         100                 105                 110

 agt gtg gaa gag cag ctg tca ctc atc agt ggt tgc cca ata tcc aag      622
 Ser Val Glu Glu Gln Leu Ser Leu Ile Ser Gly Cys Pro Ile Ser Lys
     115                 120                 125

 aag cag tat agg gtg cca tgc aca ttc agg aat gtg ttc cag aag atc      670
 Lys Gln Tyr Arg Val Pro Cys Thr Phe Arg Asn Val Phe Gln Lys Ile
 130                 135                 140                 145

 tag aact gaataagaag atttttgctc atttagattc catcattgat gatcgagtga      727
 






      <210> 458
      <211> 1548
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (236)..(697)

      <400> 458
 atgacccagg atcatgacaa acccaaagaa caaaccctaa atccaagctt tcacaagagc     60

 tacagaacct gccagcaata cacggacttc acggtgaatg ctgacagtca caagcgcgtg    120

 gtcttcccgc tttccacccc ccgacgtgcc cccgcgctgg tcctgcccct gcccacgagg    180

 gtcggcgcgc cgtgtgtctc ccggtgtcta gagtccgcgg cgtgcaccaa acatc atg     238
                                                              Met
                                                                1

 aac cat gcg tgc ctc ccc gac ttc acg gta cgg gcg cgc agc caa tgg      286
 Asn His Ala Cys Leu Pro Asp Phe Thr Val Arg Ala Arg Ser Gln Trp
               5                  10                  15

 acg cga tac ccg gcc tcc ccg gag ccc aga gct cgc agc tcc gcc ggc      334
 Thr Arg Tyr Pro Ala Ser Pro Glu Pro Arg Ala Arg Ser Ser Ala Gly
          20                  25                  30

 gcc tgg tcc cag cgc ccg cgg cgc cgc gtc ccc ggc cca acc atg gcg      382
 Ala Trp Ser Gln Arg Pro Arg Arg Arg Val Pro Gly Pro Thr Met Ala
      35                  40                  45

 tcc tcc gcg gcc ggc tgc gtg gtg atc gtt ggc agt gga gtc att ggg      430
 Ser Ser Ala Ala Gly Cys Val Val Ile Val Gly Ser Gly Val Ile Gly
  50                  55                  60                  65

 cga agc tgg gcc atg ctg ttt gcc agt gga ggc ttc cag gtg aaa ctc      478
 Arg Ser Trp Ala Met Leu Phe Ala Ser Gly Gly Phe Gln Val Lys Leu
                  70                  75                  80

 tat gac att gag caa cag cag ata agg aat gcc ctg gaa aac atc agg      526
 Tyr Asp Ile Glu Gln Gln Gln Ile Arg Asn Ala Leu Glu Asn Ile Arg
              85                  90                  95

 tgg gcc agc cgg cgc tct cca gaa gga atg gaa gtg ggt ctg ttt ctc      574
 Trp Ala Ser Arg Arg Ser Pro Glu Gly Met Glu Val Gly Leu Phe Leu
         100                 105                 110

 tca gtt ggt ctt gtt tgt cat atc ctc aag gct atg agg atc tgt gat      622
 Ser Val Gly Leu Val Cys His Ile Leu Lys Ala Met Arg Ile Cys Asp
     115                 120                 125

 gtc aca ttt tcg tct gat ggc tac tgc agt gcc tct gag ttg gta aag      670
 Val Thr Phe Ser Ser Asp Gly Tyr Cys Ser Ala Ser Glu Leu Val Lys
 130                 135                 140                 145

 gcc agg cct aca gtg gct gga atg tga attca cactggggaa gggctcccat      722
 Ala Arg Pro Thr Val Ala Gly Met 
                 150

 gggggaggaa atgacccttc ttgctaagag gatctgcatc aagcgtgagt gactttgcag    782

 gcttctccag ctgtttgccc cggggctgga gggctggggt ttcctgcttc catctaggca    842

 ggaggaactc gcttccagca tgtgacagcc atagctgcag gggcattaca gtttaagaac    902

 agaggtcctg cagcttgttt tgacctgttg atctagtaat ggtaggaccc aaatgaaaac    962

 atcttgaatt ttagttagag gtttagcact catgtgagag gacagaactg gagctgttta   1022

 tgtggttatt attaactgtg acagcggtac tagttaaagg tgtgagagtg catgaattta   1082

 cttaatgctg agtgctaaga atgcggaggg ctgttttagg gatggtagtc acgggaacca   1142

 aagaaaggct gagagtgagg gaggtcaagg acaggggaaa gaagccattg cagcgtgccc   1202

 agaagcaaag gcactggcgt ggagcaccct caccgcatgg cgcgtccccc tgcggtgccg   1262

 tcacggaaca gggttctgac catctcagac acgcgttagc tggttattat ccttatttgg   1322

 agggtgtcca tgaatatatg acttgaattt gcatttttgt gcaacaaaaa tatgcttact   1382

 ttattgtctg cattttgaaa agattaatat gtagggtata gtgttaaact ataggcatga   1442

 agaaattata taccctagcc cggtgttgtt ttacacatta agaacttgaa cacagagaag   1502

 ttaagttaaa tcttacatgt tgttacaaat agtcaatgcg agggtg                  1548




      <210> 459
      <211> 822
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (820)..(822)

      <400> 459
 tttttttttt ttaacagtcg ctgtggaatt ttattaagcc atcaaaattt ccttcacact     60

 caatactgtt gaacaacaag ataacacatc ttcttgctca tcccacttga actcaagtca    120

 tcaattttag gcacaaaggt tttagttttc tcgggaaatc aagttttaac cacttgaggt    180

 tactactgca gcaagcagat tttgttgaca aatgtgaaca gctttcaccc tctgttagta    240

 caaattaata tcctttcctt aaataaagtt agttagctat ttttggtttc aaaatcagtt    300

 tccatcataa aataacagca agacactgta cacctttacg ttcaatacta gaaatttcac    360

 ccagtgcatc agcatctgtg cggcattccc tcagcacggg ctctgctggc gggcagcagg    420

 ggtgctgagc tctctctagt gcgccctgtg cagccacacc actgctgtca ccacatgtcc    480

 ctctgacggc agaggtggta taagcagctt caccctggcc cgactgaagg ctgtcatagt    540

 tgtttttcat attatgcaca ataaactgta gcacaataat catgatataa caactgtcca    600

 gcaaaaataa aagtatttta catttgatta tcatacaaaa atatgcattt ttctattttt    660

 aaccattatt aatagtacct aatattttta aacttgtaaa ttaacaacaa taaaatacta    720

 caagagttaa aataaaataa acgtgaagga agaaaattac agagggaaaa atgctcaatc    780

 caaaacattt agtaataata aaaaagcagc taaatgaaa                   aag     834
                                              Phe Ser Phe Ser Cys
                                                1               5





      <210> 460
      <211> 5539
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (57)..(2534)

      <400> 460
 gaggtaacat ccggaattcc cgggtcgacg atttcgtgtg gcagtaaagg aggaag         56                                                                 
 atg gcg ggg tgc agg ggg tct ctg tgc tgc tgc tgc agg tgg tgc tgc      104
 Met Ala Gly Cys Arg Gly Ser Leu Cys Cys Cys Cys Arg Trp Cys Cys
   1               5                  10                  15

 tgc tgc ggt gag cgt gag acc cgc acc ccc gag gag ctg acc atc ctt      152
 Cys Cys Gly Glu Arg Glu Thr Arg Thr Pro Glu Glu Leu Thr Ile Leu
              20                  25                  30

 gga gaa aca cag gag gag gag gat gag att ctt cca agg aaa gac tat      200
 Gly Glu Thr Gln Glu Glu Glu Asp Glu Ile Leu Pro Arg Lys Asp Tyr
          35                  40                  45

 gag gtg ggt ctc ttt gtg gac ttt ttt gtg cga ctc ttc acc caa ctc      248
 Glu Val Gly Leu Phe Val Asp Phe Phe Val Arg Leu Phe Thr Gln Leu
      50                  55                  60

 aag ttc gga gtg gta cag aca tcg gtg gag gag tgc agc cag aaa ggc      296
 Lys Phe Gly Val Val Gln Thr Ser Val Glu Glu Cys Ser Gln Lys Gly
  65                  70                  75                  80

 tgc ctc gct ctg tct ctc ctt gaa ctc ctg ggt ttt aac ctc acc ttt      344
 Cys Leu Ala Leu Ser Leu Leu Glu Leu Leu Gly Phe Asn Leu Thr Phe
                  85                  90                  95

 gtc ttc ctg gca agc ctc ctt gtt ctc att gag ccg gtg gca gca ggt      392
 Val Phe Leu Ala Ser Leu Leu Val Leu Ile Glu Pro Val Ala Ala Gly
             100                 105                 110

 tcc ggg ata ccc gag gtc aaa tgc tat ctg aat ggc gta aag gtg cca      440
 Ser Gly Ile Pro Glu Val Lys Cys Tyr Leu Asn Gly Val Lys Val Pro
         115                 120                 125

 gga atc gtc cgt ctc cgg acc ctg ctc tgc aag gtc ctt gga gtg ctg      488
 Gly Ile Val Arg Leu Arg Thr Leu Leu Cys Lys Val Leu Gly Val Leu
     130                 135                 140

 ttc agt gtg gct gga ggg ctc ttc gtg ggg aag gaa ggc ccc atg atc      536
 Phe Ser Val Ala Gly Gly Leu Phe Val Gly Lys Glu Gly Pro Met Ile
 145                 150                 155                 160

 cac agt ggt tcg gtg gtg gga gct ggc ctc cct cag ttt cag agc atc      584
 His Ser Gly Ser Val Val Gly Ala Gly Leu Pro Gln Phe Gln Ser Ile
                 165                 170                 175

 tcc tta cgg aag atc cag ttt aac ttc ccc tat ttc cga agc gac aga      632
 Ser Leu Arg Lys Ile Gln Phe Asn Phe Pro Tyr Phe Arg Ser Asp Arg
             180                 185                 190

 gac aag aga gac ttt gta tca gca gga gcg gct gct gga gtt gct gca      680
 Asp Lys Arg Asp Phe Val Ser Ala Gly Ala Ala Ala Gly Val Ala Ala
         195                 200                 205

 gct ttc ggg gcg cca atc ggg ggt acc ttg ttc agt cta gag gag ggt      728
 Ala Phe Gly Ala Pro Ile Gly Gly Thr Leu Phe Ser Leu Glu Glu Gly
     210                 215                 220

 tcg tcc ttc tgg aac caa ggg ctc acg tgg aaa gtg ctc ttt tgt tcc      776
 Ser Ser Phe Trp Asn Gln Gly Leu Thr Trp Lys Val Leu Phe Cys Ser
 225                 230                 235                 240

 atg tct gcc acc ttc acc ctc aac ttc ttc cgt tct ggg att cag ttt      824
 Met Ser Ala Thr Phe Thr Leu Asn Phe Phe Arg Ser Gly Ile Gln Phe
                 245                 250                 255

 gga agc tgg ggt tcc ttc cag ctc cct gga ttg ctg aac ttt ggc gag      872
 Gly Ser Trp Gly Ser Phe Gln Leu Pro Gly Leu Leu Asn Phe Gly Glu
             260                 265                 270

 ttt aag tgc tct gac tct gat aaa aaa tgt cat ctc tgg aca gct atg      920
 Phe Lys Cys Ser Asp Ser Asp Lys Lys Cys His Leu Trp Thr Ala Met
         275                 280                 285

 gat ttg ggt ttc ttc gtc gtg atg ggg gtc att ggg ggc ctc ctg gga      968
 Asp Leu Gly Phe Phe Val Val Met Gly Val Ile Gly Gly Leu Leu Gly
     290                 295                 300

 gcc aca ttc aac tgt ctg aac aag agg ctt gca aag tac cgt atg cga     1016
 Ala Thr Phe Asn Cys Leu Asn Lys Arg Leu Ala Lys Tyr Arg Met Arg
 305                 310                 315                 320

 aac gtg cac ccg aaa cct aag ctc gtc aga gtc tta gag agc ctc ctt     1064
 Asn Val His Pro Lys Pro Lys Leu Val Arg Val Leu Glu Ser Leu Leu
                 325                 330                 335

 gtg tct ctg gta acc acc gtg gtg gtg ttt gtg gcc tcg atg gtg tta     1112
 Val Ser Leu Val Thr Thr Val Val Val Phe Val Ala Ser Met Val Leu
             340                 345                 350

 gga gaa tgc cga cag atg tcc tct tcg agt caa atc ggt aat gac tca     1160
 Gly Glu Cys Arg Gln Met Ser Ser Ser Ser Gln Ile Gly Asn Asp Ser
         355                 360                 365

 ttc cag ctc cag gtc aca gaa gat gtg aat tca agt atc aag aca ttt     1208
 Phe Gln Leu Gln Val Thr Glu Asp Val Asn Ser Ser Ile Lys Thr Phe
     370                 375                 380

 ttt tgt ccc aat gat acc tac aat gac atg gcc aca ctc ttc ttc aac     1256
 Phe Cys Pro Asn Asp Thr Tyr Asn Asp Met Ala Thr Leu Phe Phe Asn
 385                 390                 395                 400

 ccg cag gag tct gcc atc ctc cag ctc ttc cac cag gat ggt act ttc     1304
 Pro Gln Glu Ser Ala Ile Leu Gln Leu Phe His Gln Asp Gly Thr Phe
                 405                 410                 415

 agc ccc gtc act ctg gcc ttg ttc ttc gtt ctc tat ttc ttg ctt gca     1352
 Ser Pro Val Thr Leu Ala Leu Phe Phe Val Leu Tyr Phe Leu Leu Ala
             420                 425                 430

 tgt tgg act tac ggc att tct gtt cca agt ggc ctt ttt gtg cct tct     1400
 Cys Trp Thr Tyr Gly Ile Ser Val Pro Ser Gly Leu Phe Val Pro Ser
         435                 440                 445

 ctg ctg tgt gga gct gct ttt gga cgt tta gtt gcc aat gtc cta aaa     1448
 Leu Leu Cys Gly Ala Ala Phe Gly Arg Leu Val Ala Asn Val Leu Lys
     450                 455                 460

 agc tac att gga ttg ggc cac atc tat tcg ggg acc ttt gcc ctg att     1496
 Ser Tyr Ile Gly Leu Gly His Ile Tyr Ser Gly Thr Phe Ala Leu Ile
 465                 470                 475                 480

 ggt gca gcg gct ttc ttg ggc ggg gtg gtc cgc atg acc atc agc ctc     1544
 Gly Ala Ala Ala Phe Leu Gly Gly Val Val Arg Met Thr Ile Ser Leu
                 485                 490                 495

 acg gtc atc ctg atc gag tcc acc aat gag atc acc tac ggg ctc ccc     1592
 Thr Val Ile Leu Ile Glu Ser Thr Asn Glu Ile Thr Tyr Gly Leu Pro
             500                 505                 510

 atc atg gtc aca ctg atg gtg gcc aaa tgg aca ggg gac ttt ttc aat     1640
 Ile Met Val Thr Leu Met Val Ala Lys Trp Thr Gly Asp Phe Phe Asn
         515                 520                 525

 aag ggc att tat gat atc cac gtg ggc ctg cga ggc gtg ccg ctt ctg     1688
 Lys Gly Ile Tyr Asp Ile His Val Gly Leu Arg Gly Val Pro Leu Leu
     530                 535                 540

 gaa tgg gag aca gag gtg gaa atg gac aag ctg aga gcc agc gac atc     1736
 Glu Trp Glu Thr Glu Val Glu Met Asp Lys Leu Arg Ala Ser Asp Ile
 545                 550                 555                 560

 atg gag ccc aac ctg acc tac gtc tac ccg cac acc cgc atc cag tct     1784
 Met Glu Pro Asn Leu Thr Tyr Val Tyr Pro His Thr Arg Ile Gln Ser
                 565                 570                 575

 ctg gtg agc atc ctg cgc acc acg gtc cac cat gcc ttc ccg gtg gtc     1832
 Leu Val Ser Ile Leu Arg Thr Thr Val His His Ala Phe Pro Val Val
             580                 585                 590

 aca gag aac cgc ggt aac gag aag gag ttc atg aag ggc aac cag ctc     1880
 Thr Glu Asn Arg Gly Asn Glu Lys Glu Phe Met Lys Gly Asn Gln Leu
         595                 600                 605

 atc agc aac aac atc aag ttc aag aaa tcc agc atc ctc acc cgg gct     1928
 Ile Ser Asn Asn Ile Lys Phe Lys Lys Ser Ser Ile Leu Thr Arg Ala
     610                 615                 620

 ggc gag cag cgc aaa cgg agc cag tcc atg aag tcc tac cca tcc agc     1976
 Gly Glu Gln Arg Lys Arg Ser Gln Ser Met Lys Ser Tyr Pro Ser Ser
 625                 630                 635                 640

 gag cta cgg aac atg tgt gat gag cac atc gcc tct gag gag cca gcc     2024
 Glu Leu Arg Asn Met Cys Asp Glu His Ile Ala Ser Glu Glu Pro Ala
                 645                 650                 655

 gag aag gag gac ctc ctg cag cag atg ctg gaa agg aga tac act ccc     2072
 Glu Lys Glu Asp Leu Leu Gln Gln Met Leu Glu Arg Arg Tyr Thr Pro
             660                 665                 670

 tac ccc aac cta tac cct gac cag tcc cca agt gaa gac tgg acc atg     2120
 Tyr Pro Asn Leu Tyr Pro Asp Gln Ser Pro Ser Glu Asp Trp Thr Met
         675                 680                 685

 gag gag cgg ttc cgc cct ctg acc ttc cac ggc ctg atc ctt cgg tcg     2168
 Glu Glu Arg Phe Arg Pro Leu Thr Phe His Gly Leu Ile Leu Arg Ser
     690                 695                 700

 cag ctt gtc acc ctg ctt gtc cga gga gtt tgt tac tct gaa agc cag     2216
 Gln Leu Val Thr Leu Leu Val Arg Gly Val Cys Tyr Ser Glu Ser Gln
 705                 710                 715                 720

 tcg agc gcc agc cag ccg cgc ctc tcc tat gcc gag atg gcc gag gac     2264
 Ser Ser Ala Ser Gln Pro Arg Leu Ser Tyr Ala Glu Met Ala Glu Asp
                 725                 730                 735

 tac ccg cgg tac ccc gac atc cac gac ctg gac ctg acg ctg ctc aac     2312
 Tyr Pro Arg Tyr Pro Asp Ile His Asp Leu Asp Leu Thr Leu Leu Asn
             740                 745                 750

 ccg cgc atg atc gtg gat gtc acc cca tac atg aac cct tcg cct ttc     2360
 Pro Arg Met Ile Val Asp Val Thr Pro Tyr Met Asn Pro Ser Pro Phe
         755                 760                 765

 acc gtc tcg ccc aac acc cac gtc tcc caa gtc ttc aac ctg ttc aga     2408
 Thr Val Ser Pro Asn Thr His Val Ser Gln Val Phe Asn Leu Phe Arg
     770                 775                 780

 acg atg ggc ctg cgc cac ctg ccc gtg gtg aac gct gtg gga gag atc     2456
 Thr Met Gly Leu Arg His Leu Pro Val Val Asn Ala Val Gly Glu Ile
 785                 790                 795                 800

 gtg ggg atc atc aca cgg cac aac ctc acc tat gaa ttt ctg cag gcc     2504
 Val Gly Ile Ile Thr Arg His Asn Leu Thr Tyr Glu Phe Leu Gln Ala
                 805                 810                 815

 cgg ctg agg cag cac tac cag acc atc tga c agcccagccc accctctcct     2555
 Arg Leu Arg Gln His Tyr Gln Thr Ile 
             820                 825

 ggtgctgcct ggggaggcaa atcatgctca ctccggcggg gcacagctgg ctggggctgt   2615

 tccggggcat ggaagattcc cagttaccca ctcactcaga aagccgggag tcatcggaca   2675

 ccttgctggt cagaggccct gggggtggtt ttgaaccatc agagcttgga cttttctgac   2735

 ttccccagca aggatcttcc cacttcctgc tccctgtgtt cccaccctcc agtgttggca   2795

 caggccccac ccctggctcc accagagccc agaagccaga ggtagaatca ggcgggcccc   2855

 gggctgcact ccgagcagtg ttcctggcca tctttgctac tttcctagag aacccggctg   2915

 ttgccttaaa tgtgtgagag ggacttggcc aaggcaaaag ctggggagat gccagtgaca   2975

 acatacagtt catgactagg tttaggaatt gggcactgag aaaattctca atatttcaga   3035

 gagtccttcc cttatttggg actcttaaca cggtatcctc gctagttggt tttaagggaa   3095

 acactctgct cctgggtgtg agcagaggct ctggtcttgc cctgtggttt gactctcctt   3155

 agaaccaccg cccaccagaa acataaagga ttaaaatcac actaataacc cctggatggt   3215

 caatctgata ataggatcag atttacgtct accctaattc ttaacattgc agctttctct   3275

 ccatctgcag attattccca gtctcccagt aacacgtttc tacccagatc ctttttcatt   3335

 tccttaagtt ttgatctccg tcttcctgat gaagcaggca gagctcagag gatcttggca   3395

 tcacccacca aagttagctg aaagcagggc actcctggat aaagcagctt cactcaactc   3455

 tggggaatgc taccattttt tttccaaagt agaaaggaag cacttctgag ccagtgacca   3515

 ctgaaaggta tgtgctatga taaagcagat ggcctatttg aggaagaggg tgtctgccct   3575

 tcacaaacac ctctctctcc cctgcactag ctgtcccaag cttacataca gaggcccttc   3635

 aggagggcct cctgtggccg cagggagggt gcgtggggaa gatgcttcct ggccagcacg   3695

 tgcctgaagg tttcacatga agcatgggaa gcgcaccctg tcgttcagtg acgtcattct   3755

 tctccaggct ggcccgcccc ctctgactag gcacccaaag tgagcatctg ggcattgggc   3815

 attcatgctt atcttccccc accttctaca tggtattagt cccagcaggc atccctgggg   3875

 cagacgtgct ttggctcaag atggccttca tttacgttta gtttttttta aaaccgtgga   3935

 ggttgcccac gggcctcggc acctgggccc tggcagcaca gctctcaggc ccagccctgg   3995

 gcgacctcct tggccaagtc tgcctttcac cctgggggtg agcatcagtc ctggctctgc   4055

 tggtccagat cttgcgctca gcacactcta gggaataatt ccactccaga gatggggctg   4115

 cttcaaggtc ttttctagct gattgtggcc cctccatttt ccgcattttc ttatctccct   4175

 gaccaaaatt gctttgactt ctaaatgttt ctgcttccca gaatgcacct gacttatgaa   4235

 atggggataa tactcccagg aaatagcgca ggacatcaca aggaccaaaa aggcaattct   4295

 tatttaaatg ttactatttg gccagctgct gctgtgtttt atggcagtgt tcaaagcttg   4355

 atcacgttat ttcttccttt tattaagaag gaagccaatt gtccaagtca ggagaatggt   4415

 gtgatcacct gtcacagaca ctttgtcccc tctccccgcc ccttcctgga gctggcagag   4475

 ctaacgccct gcaggaggac cccggcctct cgagggctgg atcagcagcc gcctgccctg   4535

 aggctgcccc ggtgaatgtt attggaattc atccctcgtg cacatcctgt tgtgtttaag   4595

 tcaccagata ttttgttccc atcagtttag cccagagata gacagtagaa tgcaaatacc   4655

 tccctcccct aaactgactg gacggctgcc aaggaggccc caaacccagg ccccatgcaa   4715

 aggcacgtgg tttccttttc tcctctctct gcatctgcgc tttccagata agcccaaaga   4775

 cagcaacttc tccactcatg acaaatcaac tgtgaccctc gctccttcca tttctgtcca   4835

 ttagaaacca gccttttcag catctcaccc attagcagcc ccatcaccca gtgatcagtc   4895

 gcctcagtaa agcagatctg tggatgggga gcctacgggt ggtaagaagt ggtgttttgt   4955

 gtttcatctc cagcttggtg ttccatggcc cctaggcgag gtgatcaggg agtggggcca   5015

 atgggccccc ggccctggct ttgggacctt gtgctgaggg atgatttgct cctgaccttg   5075

 attaacttaa cagttcccag ctggaaggga cactttcagg acccagtcca ctgtatggca   5135

 tttgtgatgc agaattatgc actgacatga ccctgggtga caggaaagcc tttcgagagg   5195

 cccaaggtgg cctcgccagc cctgcagtat tgatgtgcag tattgcacca cagctctgcg   5255

 gaccttggcc attgccgcag tcgcagcttc cttttttctg tttgcactgt ttgtttgtat   5315

 gatgttagct aattccactg tgtatataaa ttgtattttt tttaatttgt aaaatgctat   5375

 ttttatttga acctttggaa cttgggagtt ctcattgtaa ccctaacatg tgagaataaa   5435

 atgtcttctg tctcaaaaaa aaaaaaaaaa aaaagggggg gcggtttaaa agaatcaaac   5495

 tttacgaagg cgggcttgga aggaaatatt ttttatatgg gggg                    5539




      <210> 461
      <211> 1095
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (178)..(777)

      <400> 461
 gcgatttcgt aggctgagga caaccaccgt gactcccgca gctctccagg ggaaacccta     60

 atgaaagcag aagcctggag gcaccctgaa attcctcatc tctgggagca gctaacagta    120

 gcatcgggag ctcaagtgag cccatcagga agaagctacg tctgagccta tgtccac       177                                                                 
 atg ggt tca ctg ctt ctg ttg tgg aaa ccg cat tgg aag ggc agc ggc      225
 Met Gly Ser Leu Leu Leu Leu Trp Lys Pro His Trp Lys Gly Ser Gly
   1               5                  10                  15

 ctt ggt gtt aga aga ttc cag tct gtg tcc tgg tgc tgc ccc ggc cct      273
 Leu Gly Val Arg Arg Phe Gln Ser Val Ser Trp Cys Cys Pro Gly Pro
              20                  25                  30

 ggg cct gca gct ccc aag cac aga ggc atg agt ggg gag aat gtc acc      321
 Gly Pro Ala Ala Pro Lys His Arg Gly Met Ser Gly Glu Asn Val Thr
          35                  40                  45

 agg gtc ggc acc ttc atc ctg gtg ggc ttc ccc acg gcc cca ggg ctg      369
 Arg Val Gly Thr Phe Ile Leu Val Gly Phe Pro Thr Ala Pro Gly Leu
      50                  55                  60

 cag tac ctg ctc ttc ctc ctc ttc ctg ctc acc tac ctc ttt gtc ctg      417
 Gln Tyr Leu Leu Phe Leu Leu Phe Leu Leu Thr Tyr Leu Phe Val Leu
  65                  70                  75                  80

 gtg gag aac ctg gcc atc atc ctc acc gtc tgg agc agc acc tcc ctc      465
 Val Glu Asn Leu Ala Ile Ile Leu Thr Val Trp Ser Ser Thr Ser Leu
                  85                  90                  95

 cac agg ccc atg tac tac ttt ctg agc tcc atg tct ttc cta gag atc      513
 His Arg Pro Met Tyr Tyr Phe Leu Ser Ser Met Ser Phe Leu Glu Ile
             100                 105                 110

 tgg tac gtg tct gac atc acc ccc aag atg ctg gag ggc ttc ctc ctc      561
 Trp Tyr Val Ser Asp Ile Thr Pro Lys Met Leu Glu Gly Phe Leu Leu
         115                 120                 125

 cag cag aaa cgc atc tct ttc gtc ggg tgc atg acg cag ctc tac ttc      609
 Gln Gln Lys Arg Ile Ser Phe Val Gly Cys Met Thr Gln Leu Tyr Phe
     130                 135                 140

 ttc agc tcc ctg gtg tgc acc gag tgt gtg ctt ctg gcc tcc atg gcc      657
 Phe Ser Ser Leu Val Cys Thr Glu Cys Val Leu Leu Ala Ser Met Ala
 145                 150                 155                 160

 tac gac cgc tac gtg gcc atc tgc cac ccg ctg cgc tac cac gtc ctt      705
 Tyr Asp Arg Tyr Val Ala Ile Cys His Pro Leu Arg Tyr His Val Leu
                 165                 170                 175

 gtg acc ccg ggg ctg tgc ctc cag ctg cgt cac gtt ctg tgg ctc caa      753
 Val Thr Pro Gly Leu Cys Leu Gln Leu Arg His Val Leu Trp Leu Gln
             180                 185                 190

 cgt ctt gaa cca ctt ctt ctg tga catttccccc atcctcaagc tggcctgcac     807
 Arg Leu Glu Pro Leu Leu Leu 
         195

 ggacttctcc actgcagagc tggtggattt cattctggcc ttcatcatcc tggtgtttcc    867

 actcctggcc accatgctgt catatgcgca cattaccctg gctgtcctgc gcatcccctc    927

 ggccaccggc tgctggagag ccttcttcac ctgcgcctct cacctcaccg tggtcaccgt    987

 cttctataca gccttgcttt tcatgtatgt ccggccccag gccattgatt cccggagctc   1047

 caacaagctc atctctgttt tgtacacagt tatcaccccc agtgtatt                1095




      <210> 462
      <211> 881
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (48)..(827)

      <400> 462
 tcactacaac actcaaccaa attgatgcta aaattattca gaaggaa  atg aaa act      56
                                                      Met Lys Thr
                                                        1

 ttt ttc tat ttt atc tct gtc atc aac ctt ata att ata tgt gta gac      104
 Phe Phe Tyr Phe Ile Ser Val Ile Asn Leu Ile Ile Ile Cys Val Asp
       5                  10                  15

 agt gac tta tct cag aaa gtc tat gat aca cta ctg aaa agt atc aag      152
 Ser Asp Leu Ser Gln Lys Val Tyr Asp Thr Leu Leu Lys Ser Ile Lys
  20                  25                  30                  35

 aag aat cta aaa caa ggt gta tgt gtg gac att aaa gac gtg atc att      200
 Lys Asn Leu Lys Gln Gly Val Cys Val Asp Ile Lys Asp Val Ile Ile
                  40                  45                  50

 tgg ggt aat atc agt gga aat aat tac gtt gat ctg aga aaa aca agg      248
 Trp Gly Asn Ile Ser Gly Asn Asn Tyr Val Asp Leu Arg Lys Thr Arg
              55                  60                  65

 gtg tac aga tat gag agt gcc att tgg gga cct ctt cat tat tca cgc      296
 Val Tyr Arg Tyr Glu Ser Ala Ile Trp Gly Pro Leu His Tyr Ser Arg
          70                  75                  80

 cct gtt tta aac ttg att ttt gac agt gag tgg gta aaa aga gaa ttt      344
 Pro Val Leu Asn Leu Ile Phe Asp Ser Glu Trp Val Lys Arg Glu Phe
      85                  90                  95

 gtg gca att ctt aaa aac ttg acc acc aca gga aga caa ttt gga ggc      392
 Val Ala Ile Leu Lys Asn Leu Thr Thr Thr Gly Arg Gln Phe Gly Gly
 100                 105                 110                 115

 att ttg gct gca cac agt ata gcc act aca ctg aaa tac tgg tac cat      440
 Ile Leu Ala Ala His Ser Ile Ala Thr Thr Leu Lys Tyr Trp Tyr His
                 120                 125                 130

 ggc tca cca cct ggg gag att gta tct tta gga ata ttg agt gaa ggc      488
 Gly Ser Pro Pro Gly Glu Ile Val Ser Leu Gly Ile Leu Ser Glu Gly
             135                 140                 145

 cag ttt ggt att ccg aaa ggg atc gtc ttt tct atg cct gtg aaa ttt      536
 Gln Phe Gly Ile Pro Lys Gly Ile Val Phe Ser Met Pro Val Lys Phe
         150                 155                 160

 gag aat gga act tgg gtg gtt ctt aca gat ctc aaa gat gtt gaa ata      584
 Glu Asn Gly Thr Trp Val Val Leu Thr Asp Leu Lys Asp Val Glu Ile
     165                 170                 175

 agt gaa caa ata atg acc cga atg aca agt gat cta att cag gag aaa      632
 Ser Glu Gln Ile Met Thr Arg Met Thr Ser Asp Leu Ile Gln Glu Lys
 180                 185                 190                 195

 ctt gtt gca ctt gga gac aag ata cat ttt cag cca tac caa tca gga      680
 Leu Val Ala Leu Gly Asp Lys Ile His Phe Gln Pro Tyr Gln Ser Gly
                 200                 205                 210

 cat aaa gat ctg gtc cct gat gaa gaa aaa aat cta gct atg tca gat      728
 His Lys Asp Leu Val Pro Asp Glu Glu Lys Asn Leu Ala Met Ser Asp
             215                 220                 225

 gca gca gag ttt cca aat cag att cct caa acc acc ttt gaa aag cca      776
 Ala Ala Glu Phe Pro Asn Gln Ile Pro Gln Thr Thr Phe Glu Lys Pro
         230                 235                 240

 cag agt ctt gag ttc cta aat gaa ttt gaa ggc aaa acc gtg gaa tcc      824
 Gln Ser Leu Glu Phe Leu Asn Glu Phe Glu Gly Lys Thr Val Glu Ser
     245                 250                 255

 taa caga tcaaattgga tgaaatatat aattacttga tagcacaata aacatagaaa      881
 






      <210> 463
      <211> 1353
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (1)..(1353)

      <400> 463
  atg gag ggc tct ggg ggc ggt gcg ggc gag cgg gcg ccg ctg ctg ggc      48
  Met Glu Gly Ser Gly Gly Gly Ala Gly Glu Arg Ala Pro Leu Leu Gly
    1               5                  10                  15

 gcg cgg cgg gcg gcg gcg gcc gcg gcg gcg gct ggg gcg ttc gcg ggc       96
 Ala Arg Arg Ala Ala Ala Ala Ala Ala Ala Ala Gly Ala Phe Ala Gly
              20                  25                  30

 cgg cgc gcg gcg tgc ggg gcc gtg ctg ctg acg gag ctg ctg gag cgc      144
 Arg Arg Ala Ala Cys Gly Ala Val Leu Leu Thr Glu Leu Leu Glu Arg
          35                  40                  45

 gcc gct ttc tac ggc atc acg tcc aac ctg gtg cta ttc ctg aac ggg      192
 Ala Ala Phe Tyr Gly Ile Thr Ser Asn Leu Val Leu Phe Leu Asn Gly
      50                  55                  60

 gcg ccg ttc tgc tgg gag ggc gcg cag gcc agc gag gcg ctg ctg ctc      240
 Ala Pro Phe Cys Trp Glu Gly Ala Gln Ala Ser Glu Ala Leu Leu Leu
  65                  70                  75                  80

 ttc atg ggc ctc acc tac ctg ggc tcg ccg ttc gga ggc tgg ctg gcc      288
 Phe Met Gly Leu Thr Tyr Leu Gly Ser Pro Phe Gly Gly Trp Leu Ala
                  85                  90                  95

 gac gcg cgg ctg ggc cgg gcg cgc gcc atc ctg ctg agc ctg gcg ctc      336
 Asp Ala Arg Leu Gly Arg Ala Arg Ala Ile Leu Leu Ser Leu Ala Leu
             100                 105                 110

 tac ctg ctg ggc atg ctg gcc ttc ccg ctg ctg gcc gcg ccc gcc acg      384
 Tyr Leu Leu Gly Met Leu Ala Phe Pro Leu Leu Ala Ala Pro Ala Thr
         115                 120                 125

 cga gcc gcg ctc tgc ggt tcc gcg cgc ctg ctc aac tgc acg gcg cct      432
 Arg Ala Ala Leu Cys Gly Ser Ala Arg Leu Leu Asn Cys Thr Ala Pro
     130                 135                 140

 ggt ccc gac gcc gcc gcc cgc tgc tgc tca ccg gcc acc ttc gcg ggg      480
 Gly Pro Asp Ala Ala Ala Arg Cys Cys Ser Pro Ala Thr Phe Ala Gly
 145                 150                 155                 160

 ctg gtg ctg gtg ggc ctg ggc gtg gcc acc gtc aag gcc aac atc acg      528
 Leu Val Leu Val Gly Leu Gly Val Ala Thr Val Lys Ala Asn Ile Thr
                 165                 170                 175

 ccc ttc ggc gcc gac cag cat ctt cca gag ggg agg aac act gtg tcc      576
 Pro Phe Gly Ala Asp Gln His Leu Pro Glu Gly Arg Asn Thr Val Ser
             180                 185                 190

 tcc ata gca gag gag gta gaa gga atg agc tca ccc ccg aag acc ttt      624
 Ser Ile Ala Glu Glu Val Glu Gly Met Ser Ser Pro Pro Lys Thr Phe
         195                 200                 205

 gag ggg atg aac gct gca tcc tcc ata gca gag gag agc cgg agg aag      672
 Glu Gly Met Asn Ala Ala Ser Ser Ile Ala Glu Glu Ser Arg Arg Lys
     210                 215                 220

 ggc cac tct gct gac acc gtg agc ccg gac gtc tgt ctt cca gag ccg      720
 Gly His Ser Ala Asp Thr Val Ser Pro Asp Val Cys Leu Pro Glu Pro
 225                 230                 235                 240

 gag gaa ggg cca ctc tgt gac acc gcg agc ccg gaa gtc tgt cct cca      768
 Glu Glu Gly Pro Leu Cys Asp Thr Ala Ser Pro Glu Val Cys Pro Pro
                 245                 250                 255

 gag ccg gag gaa ggg cca ctc tgt gac acc agc cgg agg aag ggc ccc      816
 Glu Pro Glu Glu Gly Pro Leu Cys Asp Thr Ser Arg Arg Lys Gly Pro
             260                 265                 270

 tct gtg aca ccg cga gcc cgg acg tct gtc ctc cag agc cgg agg aag      864
 Ser Val Thr Pro Arg Ala Arg Thr Ser Val Leu Gln Ser Arg Arg Lys
         275                 280                 285

 ggc cac tct gct gac acc ggg atc ccg gac gtc tgt cct cca gag gcg      912
 Gly His Ser Ala Asp Thr Gly Ile Pro Asp Val Cys Pro Pro Glu Ala
     290                 295                 300

 gag gaa ggg cca ctc tgt gac acc gcg atc ccg gac gtc tgt cct cca      960
 Glu Glu Gly Pro Leu Cys Asp Thr Ala Ile Pro Asp Val Cys Pro Pro
 305                 310                 315                 320

 gag gca gag gaa ggg cca ctc tgt gac acc acg agc ccg gac agc cgg     1008
 Glu Ala Glu Glu Gly Pro Leu Cys Asp Thr Thr Ser Pro Asp Ser Arg
                 325                 330                 335

 agg aag gga ccc tct gct gac acc gcg agc ccg gac gtc tgt cct cca     1056
 Arg Lys Gly Pro Ser Ala Asp Thr Ala Ser Pro Asp Val Cys Pro Pro
             340                 345                 350

 gag ccg gag gaa ggg ccc ctc tgt gac acc gcg agc ccg gac gtc tgt     1104
 Glu Pro Glu Glu Gly Pro Leu Cys Asp Thr Ala Ser Pro Asp Val Cys
         355                 360                 365

 cct cca gag ccg gag gaa ggg ccc ctc tgt gac acc gcg agc ccg gac     1152
 Pro Pro Glu Pro Glu Glu Gly Pro Leu Cys Asp Thr Ala Ser Pro Asp
     370                 375                 380

 gtc tgt cct cca gag ccg gag gaa ggg cca ctc tgt gac acc ggt att     1200
 Val Cys Pro Pro Glu Pro Glu Glu Gly Pro Leu Cys Asp Thr Gly Ile
 385                 390                 395                 400

 cac aac atg gcg gct tgc ttt ccc cag agc gag aga ttg gaa aga gat     1248
 His Asn Met Ala Ala Cys Phe Pro Gln Ser Glu Arg Leu Glu Arg Asp
                 405                 410                 415

 acc cca aga agt agt gag aga gcc tgt gca aca tgg aag cca gag act     1296
 Thr Pro Arg Ser Ser Glu Arg Ala Cys Ala Thr Trp Lys Pro Glu Thr
             420                 425                 430

 gac tgt aac cga ctt cag aag tca tat ccc atc act ttt gct aga ttt     1344
 Asp Cys Asn Arg Leu Gln Lys Ser Tyr Pro Ile Thr Phe Ala Arg Phe
         435                 440                 445

 gat tat tag                                                         1353
 Asp Tyr 
     450





      <210> 464
      <211> 1486
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (187)..(1188)

      <400> 464
 ggaattcccg ggtcgacgat ttcgtgcgac ggctgctgtg tctcctggaa agggattccc     60

 gaaaggtttt attccaaaag gagaggttgg aagacatagc tcatctcctg ctgtgtatca    120

 gccaagaagg tgtgaggtgg tgttccttgg ggatccgctt gcatctactt ggggtggttt    180

 tgaaac   atg aat ctt tcg ctc gtc ctg gct gcc ttt tgc ttg gga ata     228
          Met Asn Leu Ser Leu Val Leu Ala Ala Phe Cys Leu Gly Ile
            1               5                  10

 gcc tcc gct gtt cca aaa ttt gac caa aat ttg gat aca aag tgg tac      276
 Ala Ser Ala Val Pro Lys Phe Asp Gln Asn Leu Asp Thr Lys Trp Tyr
  15                  20                  25                  30

 cag tgg aag gca aca cac aga aga tta tat ggc gcg aat gaa gaa gga      324
 Gln Trp Lys Ala Thr His Arg Arg Leu Tyr Gly Ala Asn Glu Glu Gly
                  35                  40                  45

 tgg agg aga gca gtg tgg gaa aag aat atg aaa atg att gaa ctg cac      372
 Trp Arg Arg Ala Val Trp Glu Lys Asn Met Lys Met Ile Glu Leu His
              50                  55                  60

 aat ggg gaa tac agc caa ggg aaa cac agc ttc aca atg gcc atg aat      420
 Asn Gly Glu Tyr Ser Gln Gly Lys His Ser Phe Thr Met Ala Met Asn
          65                  70                  75

 gcc ttt gga gac atg acc aat gaa gaa ttc agg cag gtg atg aat ggt      468
 Ala Phe Gly Asp Met Thr Asn Glu Glu Phe Arg Gln Val Met Asn Gly
      80                  85                  90

 ttt caa tac cag aag cac agg aag ggg aaa cag ttc cag gaa cgc ctg      516
 Phe Gln Tyr Gln Lys His Arg Lys Gly Lys Gln Phe Gln Glu Arg Leu
  95                 100                 105                 110

 ctt ctt gag atc ccc aca tct gtg gac tgg aga gag aaa ggc tac atg      564
 Leu Leu Glu Ile Pro Thr Ser Val Asp Trp Arg Glu Lys Gly Tyr Met
                 115                 120                 125

 act cct gtg aag gat cag ggt cag tgt ggc tct tgt tgg gct ttt agt      612
 Thr Pro Val Lys Asp Gln Gly Gln Cys Gly Ser Cys Trp Ala Phe Ser
             130                 135                 140

 gca act ggt gct ctg gaa ggg cag atg ttc tgg aaa aca ggc aaa ctt      660
 Ala Thr Gly Ala Leu Glu Gly Gln Met Phe Trp Lys Thr Gly Lys Leu
         145                 150                 155

 atc tca ctg aat gag cag aat ctg gta gac tgc tct ggg cct caa ggc      708
 Ile Ser Leu Asn Glu Gln Asn Leu Val Asp Cys Ser Gly Pro Gln Gly
     160                 165                 170

 aat gag ggc tgc aat ggt gac ttc atg gat aat ccc ttc cgg tat gtt      756
 Asn Glu Gly Cys Asn Gly Asp Phe Met Asp Asn Pro Phe Arg Tyr Val
 175                 180                 185                 190

 cag gag aac gga ggc ctg gac tct gag gaa tcc tat cca tat gag gca      804
 Gln Glu Asn Gly Gly Leu Asp Ser Glu Glu Ser Tyr Pro Tyr Glu Ala
                 195                 200                 205

 aca gaa gaa tcc tgt aag tac aat ccc aag tat tct gtt gct aat gac      852
 Thr Glu Glu Ser Cys Lys Tyr Asn Pro Lys Tyr Ser Val Ala Asn Asp
             210                 215                 220

 acc ggc ttt gtg gac atc cct aag cag gag aag gcc ctg atg aag gca      900
 Thr Gly Phe Val Asp Ile Pro Lys Gln Glu Lys Ala Leu Met Lys Ala
         225                 230                 235

 gtt gca act gtg ggg ccc att tct gtt gct att gat gca ggt cat gag      948
 Val Ala Thr Val Gly Pro Ile Ser Val Ala Ile Asp Ala Gly His Glu
     240                 245                 250

 tcc ttc ctg ttc tat aaa gaa ggc att tat ttt gag cca gac tgt agc      996
 Ser Phe Leu Phe Tyr Lys Glu Gly Ile Tyr Phe Glu Pro Asp Cys Ser
 255                 260                 265                 270

 agt gaa gac atg gat cat ggt gtg ctg gtg gtt ggc tac gga ttt gaa     1044
 Ser Glu Asp Met Asp His Gly Val Leu Val Val Gly Tyr Gly Phe Glu
                 275                 280                 285

 agc aca gaa tca gat aac aat aaa tat tgg ctg gtg aag aac agc tgg     1092
 Ser Thr Glu Ser Asp Asn Asn Lys Tyr Trp Leu Val Lys Asn Ser Trp
             290                 295                 300

 ggt gaa gaa tgg ggc atg ggt ggc tac gta aag atg gcc aaa gac cgg     1140
 Gly Glu Glu Trp Gly Met Gly Gly Tyr Val Lys Met Ala Lys Asp Arg
         305                 310                 315

 aga aac cat tgt gga att gcc tca gca gcc agc tac ccc act gtg tga     1188
 Arg Asn His Cys Gly Ile Ala Ser Ala Ala Ser Tyr Pro Thr Val 
     320                 325                 330

 gctggtggac ggtgatgagg aaggacttga ctggggatgg cgcatgcatg ggaggaattc   1248

 atcttcagtc taccagcccc cgctgtgtcg gatacacact cgaatcattg aagatccgag   1308

 tgtgatttga attctgtgat attttcacac tggtaaatgt tacctctatt ttaattactg   1368

 ctataaatag gtttatatta ttgattcact tactgacttt gcattttcgt ttttaaaagg   1428

 atgtataaat ttttacctgt ttaaataaaa tttaatttca aatgtaaaaa aaaaaaaa     1486




      <210> 465
      <211> 2140
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (398)..(2140)

      <400> 465
 ctcctttccc actcccctcg gctgtcaccg acaccaagca gatccggaga aagcaaagag     60

 gatgccaaat tgggaatggg gatggggctg tggagggaga aacagatgag aggaaatcag    120

 agccctggag agagacaggc agacagatct ggagagtccg gaaaggagcc atagaagctg    180

 cccgcactgg ggatggagcc gtgcggaaac ccggggtagg gggtcctgca gcgtccttgc    240

 tgggcgcgga ggcttctccc cttgacgggt gactaactct gcctgcgtgt ttcttttgtc    300

 accagcatag gcactgagtg cggtctgtgc acccctttgc cacccaccgg tgccggcact    360

 gagcctgcaa cctgtctcac gccctctggc tgttgcc atg acg tcc acc tgc acc     415
                                          Met Thr Ser Thr Cys Thr
                                            1               5

 aac agc acg cgc gag agt aac agc agc cac acg tgc atg ccc ctc tcc      463
 Asn Ser Thr Arg Glu Ser Asn Ser Ser His Thr Cys Met Pro Leu Ser
              10                  15                  20

 aaa atg ccc atc agc ctg gcc cac ggc atc atc cgc tca acc gtg ctg      511
 Lys Met Pro Ile Ser Leu Ala His Gly Ile Ile Arg Ser Thr Val Leu
          25                  30                  35

 gtt atc ttc ctc gcc gcc tct ttc gtc ggc aac ata gtg ctg gcg cta      559
 Val Ile Phe Leu Ala Ala Ser Phe Val Gly Asn Ile Val Leu Ala Leu
      40                  45                  50

 gtg ttg cag cgc aag ccg cag ctg ctg cag gtg acc aac cgt ttt atc      607
 Val Leu Gln Arg Lys Pro Gln Leu Leu Gln Val Thr Asn Arg Phe Ile
  55                  60                  65                  70

 ttt aac ctc ctc gtc acc gac ctg ctg cag att tcg ctc gtg gcc ccc      655
 Phe Asn Leu Leu Val Thr Asp Leu Leu Gln Ile Ser Leu Val Ala Pro
                  75                  80                  85

 tgg gtg gtg gcc acc tct gtg cct ctc ttc tgg ccc ctc aac agc cac      703
 Trp Val Val Ala Thr Ser Val Pro Leu Phe Trp Pro Leu Asn Ser His
              90                  95                 100

 ttc tgc acg gcc ctg gtt agc ctc acc cac ctg ttc gcc ttc gcc agc      751
 Phe Cys Thr Ala Leu Val Ser Leu Thr His Leu Phe Ala Phe Ala Ser
         105                 110                 115

 gtc aac acc att gtc gtg gtg tca gtg gat cgc tac ttg tcc atc atc      799
 Val Asn Thr Ile Val Val Val Ser Val Asp Arg Tyr Leu Ser Ile Ile
     120                 125                 130

 cac cct ctc tcc tac ccg tcc aag atg acc cag cgc cgc ggt tac ctg      847
 His Pro Leu Ser Tyr Pro Ser Lys Met Thr Gln Arg Arg Gly Tyr Leu
 135                 140                 145                 150

 ctc ctc tat ggc acc tgg att gtg gcc atc ctg cag agc act cct cca      895
 Leu Leu Tyr Gly Thr Trp Ile Val Ala Ile Leu Gln Ser Thr Pro Pro
                 155                 160                 165

 ctc tac ggc tgg ggc cag gct gcc ttt gat gag cgc aat gct ctc tgc      943
 Leu Tyr Gly Trp Gly Gln Ala Ala Phe Asp Glu Arg Asn Ala Leu Cys
             170                 175                 180

 tcc atg atc tgg ggg gcc agc ccc agc tac act att ctc agc gtg gtg      991
 Ser Met Ile Trp Gly Ala Ser Pro Ser Tyr Thr Ile Leu Ser Val Val
         185                 190                 195

 tcc ttc atc gtc att cca ctg att gtc atg att gcc tgc tac tcc gtg     1039
 Ser Phe Ile Val Ile Pro Leu Ile Val Met Ile Ala Cys Tyr Ser Val
     200                 205                 210

 gtg ttc tgt gca gcc cgg agg cag cat gct ctg ctg tac aat gtc aag     1087
 Val Phe Cys Ala Ala Arg Arg Gln His Ala Leu Leu Tyr Asn Val Lys
 215                 220                 225                 230

 aga cac agc ttg gaa gtg cga gtc aag gac tgt gtg gag aat gag gat     1135
 Arg His Ser Leu Glu Val Arg Val Lys Asp Cys Val Glu Asn Glu Asp
                 235                 240                 245

 gaa gag gga gca gag aag aag gag gag ttc cag gat gag agt gag ttt     1183
 Glu Glu Gly Ala Glu Lys Lys Glu Glu Phe Gln Asp Glu Ser Glu Phe
             250                 255                 260

 cgc cgc cag cat gaa ggt gag gtc aag gcc aag gag ggc aga atg gaa     1231
 Arg Arg Gln His Glu Gly Glu Val Lys Ala Lys Glu Gly Arg Met Glu
         265                 270                 275

 gcc aag gac ggc agc ctg aag gcc aag gaa gga agc acg ggg acc agt     1279
 Ala Lys Asp Gly Ser Leu Lys Ala Lys Glu Gly Ser Thr Gly Thr Ser
     280                 285                 290

 gag agt agt gta gag gcc agg ggc agc gag gag gtc aga gag agc agc     1327
 Glu Ser Ser Val Glu Ala Arg Gly Ser Glu Glu Val Arg Glu Ser Ser
 295                 300                 305                 310

 acg gtg gcc agc gac ggc agc atg gag ggt aag gaa ggc agc acc aaa     1375
 Thr Val Ala Ser Asp Gly Ser Met Glu Gly Lys Glu Gly Ser Thr Lys
                 315                 320                 325

 gtt gag gag aac agc atg aag gca gac aag ggt cgc aca gag gtc aac     1423
 Val Glu Glu Asn Ser Met Lys Ala Asp Lys Gly Arg Thr Glu Val Asn
             330                 335                 340

 cag tgc agc att gac ttg ggt gaa gat gac atg gag ttt ggt gaa gac     1471
 Gln Cys Ser Ile Asp Leu Gly Glu Asp Asp Met Glu Phe Gly Glu Asp
         345                 350                 355

 gac atc aat ttc agt gag gat gac gtc gag gca gtg aac atc ccg gag     1519
 Asp Ile Asn Phe Ser Glu Asp Asp Val Glu Ala Val Asn Ile Pro Glu
     360                 365                 370

 agc ctc cca ccc agt cgt cgt aac agc aac agc aac cct cct ctg ccc     1567
 Ser Leu Pro Pro Ser Arg Arg Asn Ser Asn Ser Asn Pro Pro Leu Pro
 375                 380                 385                 390

 agg tgc tac cag tgc aaa gct gct aaa gtg atc ttc atc atc att ttc     1615
 Arg Cys Tyr Gln Cys Lys Ala Ala Lys Val Ile Phe Ile Ile Ile Phe
                 395                 400                 405

 tcc tat gtg cta tcc ctg ggg ccc tac tgc ttt tta gca gtc ctg gcc     1663
 Ser Tyr Val Leu Ser Leu Gly Pro Tyr Cys Phe Leu Ala Val Leu Ala
             410                 415                 420

 gtg tgg gtg gat gtc gaa acc cag gta ccc cag tgg gtg atc acc ata     1711
 Val Trp Val Asp Val Glu Thr Gln Val Pro Gln Trp Val Ile Thr Ile
         425                 430                 435

 atc atc tgg ctt ttc ttc ctg cag tgc tgc atc cac ccc tat gtc tat     1759
 Ile Ile Trp Leu Phe Phe Leu Gln Cys Cys Ile His Pro Tyr Val Tyr
     440                 445                 450

 ggc tac atg cac aag acc att aag aag gaa atc cag gac atg ctg aag     1807
 Gly Tyr Met His Lys Thr Ile Lys Lys Glu Ile Gln Asp Met Leu Lys
 455                 460                 465                 470

 aag ttc ttc tgc aag gaa aag ccc ccg aaa gaa gat agc cac cca gac     1855
 Lys Phe Phe Cys Lys Glu Lys Pro Pro Lys Glu Asp Ser His Pro Asp
                 475                 480                 485

 ctg ccc gga aca gag gtt agt tct aag gca aac ctt gaa ctg tcc ata     1903
 Leu Pro Gly Thr Glu Val Ser Ser Lys Ala Asn Leu Glu Leu Ser Ile
             490                 495                 500

 aca cga gaa aca aga gga gat ttc ttt tca atg gac cca caa ttc att     1951
 Thr Arg Glu Thr Arg Gly Asp Phe Phe Ser Met Asp Pro Gln Phe Ile
         505                 510                 515

 aat gcc aaa cca tac cat ttc agg caa agg aaa ggg aag atg atg ctt     1999
 Asn Ala Lys Pro Tyr His Phe Arg Gln Arg Lys Gly Lys Met Met Leu
     520                 525                 530

 gtg aac tta agg act ttt cgg ccc tcg ggt cgg gag ctc atg ggc cag     2047
 Val Asn Leu Arg Thr Phe Arg Pro Ser Gly Arg Glu Leu Met Gly Gln
 535                 540                 545                 550

 agc tac agc ttg tgt tca act gaa aga aag gca atg gac caa atc att     2095
 Ser Tyr Ser Leu Cys Ser Thr Glu Arg Lys Ala Met Asp Gln Ile Ile
                 555                 560                 565

 cat gga gcc caa gaa aca gaa cct aat gga ctg atc aac ata tga         2140
 His Gly Ala Gln Glu Thr Glu Pro Asn Gly Leu Ile Asn Ile 
             570                 575                 580





      <210> 466
      <211> 769
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (497)..(769)

      <400> 466
 ttaaagagct ttgtggatct tgcttggtgt gtttactggg gataacttaa cttttggcaa     60

 tccccagact gccatgaaaa cagcaaagaa gacagtggct ccattgtcaa aaaggtgggt    120

 taccttggca tatacacagc tgtctgacag cctcatgaat ggacagtatt tatcacacac    180

 aggacacatg atgatatctg tagcttggca gacttcttta ctgacttggc tgtgatccag    240

 agtggtgacg ccatacaaaa agacaaacaa tccaatgaag gcagctggga agagcatgcc    300

 ggtgtaccag cccaaccagg caaaatataa cccaatcttc tctccaaagt accgccttac    360

 aagatccaaa ggttggtatt tataccacac gccccaggag gcccagcact catagagtag    420

 atgtcggtgt tggatcttgc ggtactttgg agagaagatt gggttatatt ttgcctggtt    480

 gggctggtac accggc    atg ctc ttc cca gct gcc ttc att gga ttg ttt     529
                      Met Leu Phe Pro Ala Ala Phe Ile Gly Leu Phe
                        1               5                  10

 gtc ttt ttg tat ggc gtc acc act ctg gat cac agc caa gtc agt aaa      577
 Val Phe Leu Tyr Gly Val Thr Thr Leu Asp His Ser Gln Val Ser Lys
              15                  20                  25

 gaa gtc tgc caa gct aca gat atc atc atg tgt cct gtg tgt gat aaa      625
 Glu Val Cys Gln Ala Thr Asp Ile Ile Met Cys Pro Val Cys Asp Lys
          30                  35                  40

 tac tgt cca ttc atg agg ctg tca gac agc tgt gta tat gcc aag gta      673
 Tyr Cys Pro Phe Met Arg Leu Ser Asp Ser Cys Val Tyr Ala Lys Val
      45                  50                  55

 att tca aac tgt agc att tta gat gaa ttg aat tta aca tac acc ttc      721
 Ile Ser Asn Cys Ser Ile Leu Asp Glu Leu Asn Leu Thr Tyr Thr Phe
  60                  65                  70                  75

 ctg agg gat gga ctg att ttg gca gaa ggt gtc atc agc tta agc taa      769
 Leu Arg Asp Gly Leu Ile Leu Ala Glu Gly Val Ile Ser Leu Ser 
                  80                  85                  90





      <210> 467
      <211> 2268
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (634)..(2268)

      <400> 467
 gaaggagaga aacgcggagg aacgggatac cacaacacgg acgagcgaag gcagtacgcg     60

 acggcgctct cgttttacgg gtcttctata aagcgcggcc tctcaccgta cgcgggggcg    120

 aatactcccg gaagcgaggt agtgcggatg gagagacgag aactcgacaa agggagatta    180

 tggcatcagc tatcttgtgg ggagaattct gagatgacag cctccagtga aacactaggg    240

 acaaaggccc attcacctct tcaagaaacc agggaagggg aaaatgaagc tgttggaaca    300

 tccaggaagg gaacagggca ggatgcacct gcaaagagga ctctgtgggt tcggggagaa    360

 gccatctcag tgacaatgtc catcgcaatc ctggttcttt tgagagaggt acatggtgac    420

 atgtcaaaca gcgactcttg tatccttagg gaagctctaa tcatcaaagt gtattcaata    480

 tacgtcttgg actcaactgg tgcatctcgc ctttctgtag cagcaccatc tatacctctg    540

 catattctag actttcgagc tccagagacc attgagagtg tagctcaagg aatccgtaag    600

 aactgcccct ttgattatgc ctgcatcact gac atg gtg aaa tca tca gaa aca     654
                                      Met Val Lys Ser Ser Glu Thr
                                        1               5

 aca tct gga aat att gca ttt ata gtg gag tta tta aaa aat att tct      702
 Thr Ser Gly Asn Ile Ala Phe Ile Val Glu Leu Leu Lys Asn Ile Ser
          10                  15                  20

 aca gac ttg tct gat aat gtt act cga gag aaa atg aag agc tat agt      750
 Thr Asp Leu Ser Asp Asn Val Thr Arg Glu Lys Met Lys Ser Tyr Ser
      25                  30                  35

 gaa gtg gcc aac cac atc ctc gac aca gca gcc att tca aac tgg gct      798
 Glu Val Ala Asn His Ile Leu Asp Thr Ala Ala Ile Ser Asn Trp Ala
  40                  45                  50                  55

 ttc att ccc aac aaa aat gcc agc tcg gat ttg ttg cag tca gtg aat      846
 Phe Ile Pro Asn Lys Asn Ala Ser Ser Asp Leu Leu Gln Ser Val Asn
                  60                  65                  70

 ttg ttt gcc aga caa ctc cac atc cac aat aat tct gag aac att gtg      894
 Leu Phe Ala Arg Gln Leu His Ile His Asn Asn Ser Glu Asn Ile Val
              75                  80                  85

 aat gaa ctc ttc att cag aca aaa ggg ttt cac atc aac cat aat acc      942
 Asn Glu Leu Phe Ile Gln Thr Lys Gly Phe His Ile Asn His Asn Thr
          90                  95                 100

 tca gag aaa agc ctc aat ttc tcc atg agc atg aac aat acc aca gaa      990
 Ser Glu Lys Ser Leu Asn Phe Ser Met Ser Met Asn Asn Thr Thr Glu
     105                 110                 115

 gat atc tta gga atg gta cag att ccc agg caa gag cta agg aag ctg     1038
 Asp Ile Leu Gly Met Val Gln Ile Pro Arg Gln Glu Leu Arg Lys Leu
 120                 125                 130                 135

 tgg cca aat gca tcc caa gcc att agc ata gct ttc cca acc ttg ggg     1086
 Trp Pro Asn Ala Ser Gln Ala Ile Ser Ile Ala Phe Pro Thr Leu Gly
                 140                 145                 150

 gct atc ctg aga gaa gcc cac ttg caa aat gtg agt ctt ccc aga cag     1134
 Ala Ile Leu Arg Glu Ala His Leu Gln Asn Val Ser Leu Pro Arg Gln
             155                 160                 165

 gta aat ggt ctg gtg cta tca gtg gtt tta cca gaa agg ttg caa gaa     1182
 Val Asn Gly Leu Val Leu Ser Val Val Leu Pro Glu Arg Leu Gln Glu
         170                 175                 180

 atc ata ctc acc ttc gaa aag atc aat aaa acc cgc aat gcc aga gcc     1230
 Ile Ile Leu Thr Phe Glu Lys Ile Asn Lys Thr Arg Asn Ala Arg Ala
     185                 190                 195

 cag tgt gtt ggc tgg cac tcc aag aaa agg aga tgg gat gag aaa gcg     1278
 Gln Cys Val Gly Trp His Ser Lys Lys Arg Arg Trp Asp Glu Lys Ala
 200                 205                 210                 215

 tgc caa atg atg ttg gat atc agg aac gaa gtg aaa tgc cgc tgt aac     1326
 Cys Gln Met Met Leu Asp Ile Arg Asn Glu Val Lys Cys Arg Cys Asn
                 220                 225                 230

 tac acc agt gtg gtg atg tct ttt tcc att ctc atg tcc tcc aaa tcg     1374
 Tyr Thr Ser Val Val Met Ser Phe Ser Ile Leu Met Ser Ser Lys Ser
             235                 240                 245

 atg acc gac aaa gtt ctg gac tac atc acc tgc att ggg ctc agc gtc     1422
 Met Thr Asp Lys Val Leu Asp Tyr Ile Thr Cys Ile Gly Leu Ser Val
         250                 255                 260

 tca atc cta agc ttg gtt ctt tgc ctg atc att gaa gcc aca gtg tgg     1470
 Ser Ile Leu Ser Leu Val Leu Cys Leu Ile Ile Glu Ala Thr Val Trp
     265                 270                 275

 tcc cgg gtg gtt gtg acg gag ata tca tac atg cgt cac gtg tgc atc     1518
 Ser Arg Val Val Val Thr Glu Ile Ser Tyr Met Arg His Val Cys Ile
 280                 285                 290                 295

 gtg aat ata gca gtg tcc ctt ctg act gcc aat gtg tgg ttt atc ata     1566
 Val Asn Ile Ala Val Ser Leu Leu Thr Ala Asn Val Trp Phe Ile Ile
                 300                 305                 310

 ggc tct cac ttt aac att aag gcc cag gac tac aac atg tgt gtt gca     1614
 Gly Ser His Phe Asn Ile Lys Ala Gln Asp Tyr Asn Met Cys Val Ala
             315                 320                 325

 gtg aca ttt ttc agc cac ttt ttc tac ctc tct ctg ttt ttc tgg atg     1662
 Val Thr Phe Phe Ser His Phe Phe Tyr Leu Ser Leu Phe Phe Trp Met
         330                 335                 340

 ctc ttc aaa gca ttg ctc atc att tat gga ata ttg gtc att ttc cgt     1710
 Leu Phe Lys Ala Leu Leu Ile Ile Tyr Gly Ile Leu Val Ile Phe Arg
     345                 350                 355

 agg atg atg aag tcc cga atg atg gtc att ggc ttt gcc att ggc tat     1758
 Arg Met Met Lys Ser Arg Met Met Val Ile Gly Phe Ala Ile Gly Tyr
 360                 365                 370                 375

 ggg tgc cca ttg atc att gct gtc act aca gtt gct atc aca gag cca     1806
 Gly Cys Pro Leu Ile Ile Ala Val Thr Thr Val Ala Ile Thr Glu Pro
                 380                 385                 390

 gag aaa ggc tac atg aga cct gag gcc tgt tgg ctt aac tgg gac aat     1854
 Glu Lys Gly Tyr Met Arg Pro Glu Ala Cys Trp Leu Asn Trp Asp Asn
             395                 400                 405

 acc aaa gcc ctt tta gca ttt gcc atc ccg gcg ttc gtc att gtg gct     1902
 Thr Lys Ala Leu Leu Ala Phe Ala Ile Pro Ala Phe Val Ile Val Ala
         410                 415                 420

 gta aat ctg att gtg gtt ttg gtt gtt gct gtc aac act cag agg ccc     1950
 Val Asn Leu Ile Val Val Leu Val Val Ala Val Asn Thr Gln Arg Pro
     425                 430                 435

 tct att ggc agt tcc aag tct cag gat gtg gtc ata att atg agg atc     1998
 Ser Ile Gly Ser Ser Lys Ser Gln Asp Val Val Ile Ile Met Arg Ile
 440                 445                 450                 455

 agc aaa aat gtt gcc atc ctc act cca ctg ctg gga ctg acc tgg ggt     2046
 Ser Lys Asn Val Ala Ile Leu Thr Pro Leu Leu Gly Leu Thr Trp Gly
                 460                 465                 470

 ttt gga ata gcc act ctc ata gaa ggc act tcc ttg acg ttc cat ata     2094
 Phe Gly Ile Ala Thr Leu Ile Glu Gly Thr Ser Leu Thr Phe His Ile
             475                 480                 485

 att ttt gcc ttg ctc aat gct ttc cag ata aga gat gct ttg agg atg     2142
 Ile Phe Ala Leu Leu Asn Ala Phe Gln Ile Arg Asp Ala Leu Arg Met
         490                 495                 500

 agg atg tct tca ctg aag ggg aaa tcg agg gca gct gag ccc tgg aga     2190
 Arg Met Ser Ser Leu Lys Gly Lys Ser Arg Ala Ala Glu Pro Trp Arg
     505                 510                 515

 gtc cgt gtc ctt gcc ggt tat gca gag aca aat acc ata gct cag tac     2238
 Val Arg Val Leu Ala Gly Tyr Ala Glu Thr Asn Thr Ile Ala Gln Tyr
 520                 525                 530                 535

 tca gga tct gtg ggc aaa gag gat caa taa                             2268
 Ser Gly Ser Val Gly Lys Glu Asp Gln 
                 540





      <210> 468
      <211> 516
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (105)..(302)

      <400> 468
 aaattctgcc ttcacccagt atatctttcc aatgtaggat gatttatttt tcattacatt     60

 tgttctaaga ttttgtagtg attactctag tgtttgtcat gtaa atg tta gtt tat     116
                                                  Met Leu Val Tyr
                                                    1

 caa aat cag gct cag ttc tcc agt aat atg tgg tta aat ttc agt gat      164
 Gln Asn Gln Ala Gln Phe Ser Ser Asn Met Trp Leu Asn Phe Ser Asp
   5                  10                  15                  20

 gta cac aca tat ttg tcc tct ata gct cta tta tgt ttt tgc ctt tct      212
 Val His Thr Tyr Leu Ser Ser Ile Ala Leu Leu Cys Phe Cys Leu Ser
                  25                  30                  35

 ggg gta ctt tgt tgc ata tgt aac aac tca gtg ttc cac att caa caa      260
 Gly Val Leu Cys Cys Ile Cys Asn Asn Ser Val Phe His Ile Gln Gln
              40                  45                  50

 tat att ctt ata att att act ttt cca ctg gta gtc att tag ttccagt      309
 Tyr Ile Leu Ile Ile Ile Thr Phe Pro Leu Val Val Ile 
          55                  60                  65

 ttttatgggt gttatttata aatataatac atgtatgtta catttttcta tgttgtaggc    369

 ctaacaatcc attactactt attactttac acaattgact tgtgaatcca taacaaggag    429

 aaaggtgaag aaacacatat tcagtttgtc ttttccactt atatagtctt gcatagtgct    489

 acactggttg ctatgggaga gtacaaa                                        516




      <210> 469
      <211> 1065
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (1)..(1011)

      <400> 469
  atg ctt cgc ggt cag gcg agt aag cgc cgt gcc cgt gag aaa cgc cgc      48
  Met Leu Arg Gly Gln Ala Ser Lys Arg Arg Ala Arg Glu Lys Arg Arg
    1               5                  10                  15

 cag gct cga ggt gaa gac caa tgt ctc ggg ggt gct caa gcc acc gca       96
 Gln Ala Arg Gly Glu Asp Gln Cys Leu Gly Gly Ala Gln Ala Thr Ala
              20                  25                  30

 gca gag aag gaa aag ctg cca tcc tcc tcc tct cct gaa tgc cag atc      144
 Ala Glu Lys Glu Lys Leu Pro Ser Ser Ser Ser Pro Glu Cys Gln Ile
          35                  40                  45

 ctc ccc aga gct tcc cca aat gca ggc att cct cag gag tcc cag aga      192
 Leu Pro Arg Ala Ser Pro Asn Ala Gly Ile Pro Gln Glu Ser Gln Arg
      50                  55                  60

 gcc agc tac ccc agc tct cct gct tca gct gtt tca ctc aca agt tct      240
 Ala Ser Tyr Pro Ser Ser Pro Ala Ser Ala Val Ser Leu Thr Ser Ser
  65                  70                  75                  80

 gat gaa ggt gcc aag ggc caa aag ggg gaa agt ccc aac tcc ttc cat      288
 Asp Glu Gly Ala Lys Gly Gln Lys Gly Glu Ser Pro Asn Ser Phe His
                  85                  90                  95

 ggc ccg tcc tcc tct gag agc aca gga aga gat ctt ctg aac acg aag      336
 Gly Pro Ser Ser Ser Glu Ser Thr Gly Arg Asp Leu Leu Asn Thr Lys
             100                 105                 110

 acg ggc gaa ttg gtg cag ttc ctc ctc aac aag tat ata agg aaa gag      384
 Thr Gly Glu Leu Val Gln Phe Leu Leu Asn Lys Tyr Ile Arg Lys Glu
         115                 120                 125

 ccc att acg agg gaa gcc atg ctg aag gtt atc aac aga aag tac aag      432
 Pro Ile Thr Arg Glu Ala Met Leu Lys Val Ile Asn Arg Lys Tyr Lys
     130                 135                 140

 cag cac ttc cct gag atc ctc cgg aga agc act gag aac gta gag gtg      480
 Gln His Phe Pro Glu Ile Leu Arg Arg Ser Thr Glu Asn Val Glu Val
 145                 150                 155                 160

 gtc ttt ggc ctc tac ctg aag gaa atg gac ccc agc cgt cag tcc tat      528
 Val Phe Gly Leu Tyr Leu Lys Glu Met Asp Pro Ser Arg Gln Ser Tyr
                 165                 170                 175

 gtg ctt gtt ggc aag ctg gac ttt ccc aat caa gga agc ttg agc gat      576
 Val Leu Val Gly Lys Leu Asp Phe Pro Asn Gln Gly Ser Leu Ser Asp
             180                 185                 190

 ggc ggg ggc ttt ccc ctg agc ggg ctc ctg atg gtt ctc ctg agc acc      624
 Gly Gly Gly Phe Pro Leu Ser Gly Leu Leu Met Val Leu Leu Ser Thr
         195                 200                 205

 atc ttc atg cat ggc aac cgt gcc act gag gaa gag atg tgg gag tgc      672
 Ile Phe Met His Gly Asn Arg Ala Thr Glu Glu Glu Met Trp Glu Cys
     210                 215                 220

 ctg aat gca ttg ggg atg tat aag ggt agg aag cac ttc atc tat ggg      720
 Leu Asn Ala Leu Gly Met Tyr Lys Gly Arg Lys His Phe Ile Tyr Gly
 225                 230                 235                 240

 gag ccc cag gag ctt gtc acc aaa gat ttg gtg cga gag ggg tac ctg      768
 Glu Pro Gln Glu Leu Val Thr Lys Asp Leu Val Arg Glu Gly Tyr Leu
                 245                 250                 255

 gag tac cag cag gtg ccc agc agc gat cct cca cgc tac gag ttc ctg      816
 Glu Tyr Gln Gln Val Pro Ser Ser Asp Pro Pro Arg Tyr Glu Phe Leu
             260                 265                 270

 tgg ggt ccc agg gcc cgt gct gaa acc agc aaa atg aaa gtc ctg gag      864
 Trp Gly Pro Arg Ala Arg Ala Glu Thr Ser Lys Met Lys Val Leu Glu
         275                 280                 285

 ttt gtg gcc aag ctc aat gat acc gtt gcc agt acc tac aag tcc cgg      912
 Phe Val Ala Lys Leu Asn Asp Thr Val Ala Ser Thr Tyr Lys Ser Arg
     290                 295                 300

 tat gag gag gct ctg aga gag gag gaa gag caa gcc aga gcc aga gcg      960
 Tyr Glu Glu Ala Leu Arg Glu Glu Glu Glu Gln Ala Arg Ala Arg Ala
 305                 310                 315                 320

 gta gcc agg gat agc gcc agg gcc agg gct agc agg tcc ttt cag ccc     1008
 Val Ala Arg Asp Ser Ala Arg Ala Arg Ala Ser Arg Ser Phe Gln Pro
                 325                 330                 335

 tag tgaa gtctcaggca atcctcacta agagattgaa aagcctgtcc accatctcag     1065
 






      <210> 470
      <211> 1870
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (189)..(1820)

      <400> 470
 cagtggtaca acgcaaagta cgcgggagat aggcaggcgc caggtcctgg aagggagagt     60

 cagggagcaa ggcatggagc ctgcacttta ctctgaatgt tggtggcgcc ttcagagcat    120

 tgttagcagg ggtccatgtg atcacactga cacctgagag agtgacacac catgtacatg    180

 gctggtat atg gag gat gga ttt aag ggg gac agg act gaa ggc tgt cgc     230
          Met Glu Asp Gly Phe Lys Gly Asp Arg Thr Glu Gly Cys Arg
            1               5                  10

 agt gat tca gtg gcc gtt ccc gca gca gca ccg gtg tgc cag ccc aag      278
 Ser Asp Ser Val Ala Val Pro Ala Ala Ala Pro Val Cys Gln Pro Lys
  15                  20                  25                  30

 agc gcc act aac ggg caa ccc ccg gct ccg gct ccg act cca act ccg      326
 Ser Ala Thr Asn Gly Gln Pro Pro Ala Pro Ala Pro Thr Pro Thr Pro
                  35                  40                  45

 cgc ctg tcc att tcc tcc cga gcc aca gtg gta gcc agg atg gaa ggc      374
 Arg Leu Ser Ile Ser Ser Arg Ala Thr Val Val Ala Arg Met Glu Gly
              50                  55                  60

 acc tcc caa ggg ggc ttg cag acc gtc atg aag tgg aag acg gtg gtt      422
 Thr Ser Gln Gly Gly Leu Gln Thr Val Met Lys Trp Lys Thr Val Val
          65                  70                  75

 gcc atc ttt gtg gtt gtg gtg gtc tac ctt gtc act ggc ggt ctt gtc      470
 Ala Ile Phe Val Val Val Val Val Tyr Leu Val Thr Gly Gly Leu Val
      80                  85                  90

 ttc cgg gca ttg gag cag ccc ttt gag agc agc cag aag aat acc atc      518
 Phe Arg Ala Leu Glu Gln Pro Phe Glu Ser Ser Gln Lys Asn Thr Ile
  95                 100                 105                 110

 gcc ttg gag aag gcg gaa ttc ctg cgg gat cat gtc tgt gtg agc ccc      566
 Ala Leu Glu Lys Ala Glu Phe Leu Arg Asp His Val Cys Val Ser Pro
                 115                 120                 125

 cag gag ctg gag acg ttg atc cag cat gct ctt gat gct gac aat gcg      614
 Gln Glu Leu Glu Thr Leu Ile Gln His Ala Leu Asp Ala Asp Asn Ala
             130                 135                 140

 gga gtc agt cca ata gga aac tct tcc aac aac agc agc cac tgg gac      662
 Gly Val Ser Pro Ile Gly Asn Ser Ser Asn Asn Ser Ser His Trp Asp
         145                 150                 155

 ctc ggc agt gcc ttt ttc ttt gct gga act gtc att acg acc ata ggg      710
 Leu Gly Ser Ala Phe Phe Phe Ala Gly Thr Val Ile Thr Thr Ile Gly
     160                 165                 170

 tat ggg aat att gct ccg agc act gaa gga ggc aaa atc ttt tgt att      758
 Tyr Gly Asn Ile Ala Pro Ser Thr Glu Gly Gly Lys Ile Phe Cys Ile
 175                 180                 185                 190

 tta tat gcc atc ttt gga att cca ctc ttt ggt ttc tta ttg gct gga      806
 Leu Tyr Ala Ile Phe Gly Ile Pro Leu Phe Gly Phe Leu Leu Ala Gly
                 195                 200                 205

 att gga gac caa ctt gga acc atc ttt ggg aaa agc att gca aga gtg      854
 Ile Gly Asp Gln Leu Gly Thr Ile Phe Gly Lys Ser Ile Ala Arg Val
             210                 215                 220

 gag aag gtc ttt cga aaa aag caa gtg agt cag acc aag atc cgg gtc      902
 Glu Lys Val Phe Arg Lys Lys Gln Val Ser Gln Thr Lys Ile Arg Val
         225                 230                 235

 atc tca acc atc ctg ttc atc ttg gcc ggc tgc att gtg ttt gtg acg      950
 Ile Ser Thr Ile Leu Phe Ile Leu Ala Gly Cys Ile Val Phe Val Thr
     240                 245                 250

 atc cct gct gtc atc ttt aag tac atc gag ggc tgg acg gcc ttg gag      998
 Ile Pro Ala Val Ile Phe Lys Tyr Ile Glu Gly Trp Thr Ala Leu Glu
 255                 260                 265                 270

 tcc att tac ttt gtg gtg gtc act ctg acc acg gtg ggc ttt ggt gat     1046
 Ser Ile Tyr Phe Val Val Val Thr Leu Thr Thr Val Gly Phe Gly Asp
                 275                 280                 285

 ttt gtg gca ggg gga aac gct ggc atc aat tat cgg gag tgg tat aag     1094
 Phe Val Ala Gly Gly Asn Ala Gly Ile Asn Tyr Arg Glu Trp Tyr Lys
             290                 295                 300

 ccc cta gtg tgg ttt tgg atc ctt gtt ggc ctt gcc tac ttt gca gct     1142
 Pro Leu Val Trp Phe Trp Ile Leu Val Gly Leu Ala Tyr Phe Ala Ala
         305                 310                 315

 gtc ctc agt atg atc gga gat tgg cta cgg gtt ctg tcc aaa aag aca     1190
 Val Leu Ser Met Ile Gly Asp Trp Leu Arg Val Leu Ser Lys Lys Thr
     320                 325                 330

 aaa gaa gag gtg ggt gaa atc aag gcc cat gcg gca gag tgg aag gcc     1238
 Lys Glu Glu Val Gly Glu Ile Lys Ala His Ala Ala Glu Trp Lys Ala
 335                 340                 345                 350

 aat gtc acg gct gag ttc cgg gag aca cgg cga agg ctc agc gtg gag     1286
 Asn Val Thr Ala Glu Phe Arg Glu Thr Arg Arg Arg Leu Ser Val Glu
                 355                 360                 365

 atc cac gat aag ctg cag cgg gcg gcc acc atc cgc agc atg gag cgc     1334
 Ile His Asp Lys Leu Gln Arg Ala Ala Thr Ile Arg Ser Met Glu Arg
             370                 375                 380

 cgg cgg ctg ggc ctg gac cag cgg gcc cac tca ctg gac atg ctg tcc     1382
 Arg Arg Leu Gly Leu Asp Gln Arg Ala His Ser Leu Asp Met Leu Ser
         385                 390                 395

 ccc gag aag cgc tct gtc ttt gct gcc ctg gac acc ggc cgc ttc aag     1430
 Pro Glu Lys Arg Ser Val Phe Ala Ala Leu Asp Thr Gly Arg Phe Lys
     400                 405                 410

 gcc tca tcc cag gag agc atc aac aac cgg ccc aac aac ctg cgc ctg     1478
 Ala Ser Ser Gln Glu Ser Ile Asn Asn Arg Pro Asn Asn Leu Arg Leu
 415                 420                 425                 430

 aag ggg ccg gag cag ctg aac aag cat ggg cag ggt gcg tcc gag gac     1526
 Lys Gly Pro Glu Gln Leu Asn Lys His Gly Gln Gly Ala Ser Glu Asp
                 435                 440                 445

 aac atc atc aac aag ttc ggg tcc acc tcc aga ctc acc aag agg aaa     1574
 Asn Ile Ile Asn Lys Phe Gly Ser Thr Ser Arg Leu Thr Lys Arg Lys
             450                 455                 460

 aac aag gac ctc aaa aag acc ttg ccc gag gac gtt cag aaa atc tac     1622
 Asn Lys Asp Leu Lys Lys Thr Leu Pro Glu Asp Val Gln Lys Ile Tyr
         465                 470                 475

 aag acc ttc cgg aat tac tcc ctg gac gag gag aag aaa gag gag gag     1670
 Lys Thr Phe Arg Asn Tyr Ser Leu Asp Glu Glu Lys Lys Glu Glu Glu
     480                 485                 490

 acg gaa aag atg tgt aac tca gac aac tcc agc aca gcc atg ctg acg     1718
 Thr Glu Lys Met Cys Asn Ser Asp Asn Ser Ser Thr Ala Met Leu Thr
 495                 500                 505                 510

 gac tgt atc cag cag cac gct gag ttg gag aac gga atg ata ccc acg     1766
 Asp Cys Ile Gln Gln His Ala Glu Leu Glu Asn Gly Met Ile Pro Thr
                 515                 520                 525

 gac acc aaa gac cgg gag ccg gag aac aac tca tta ctt gaa gac aga     1814
 Asp Thr Lys Asp Arg Glu Pro Glu Asn Asn Ser Leu Leu Glu Asp Arg
             530                 535                 540

 aac taa atgtgaagga cattggtctt ggactgagcg ttgtgtgtgt gtgtgtgtgt      1870
 Asn 






      <210> 471
      <211> 2256
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (421)..(2037)

      <400> 471
 atggtggaag gagacgctgg aacctcagac aagaagtctg gatttgtggg ctgtggagac     60

 tcagggacag tgagctcctc actctatctc tcactctctc tcctcctaac tgctgcttct    120

 gcaaagagtg tgtgcaggca acaggaaaca aatacagagg gcagagcaag gattggtcag    180

 gacgggctta gtgagaaagg ctctgaacga gacacacacc agctgcagct tcgtactgac    240

 acctgccagc tcctacacac cttcctgggc aactgccagc ggggcaaggc aggcctgggg    300

 ccaccctgca ggcagtgtct gggccctcag ctccccctcc ctccacctac cccctcacac    360

 ccaccactac gaccccacgg gatacccagc ccagacggag gaaacaccga gcctagagac    420
                                                                 
 atg aga gtt gga gga gca ttc cac ctt cta ctc gtg tgc ctg agc cca      468
 Met Arg Val Gly Gly Ala Phe His Leu Leu Leu Val Cys Leu Ser Pro
   1               5                  10                  15

 gca ctg ctg tct gct gtg cgg atc aac ggg gat gga cag gag gtc ctg      516
 Ala Leu Leu Ser Ala Val Arg Ile Asn Gly Asp Gly Gln Glu Val Leu
              20                  25                  30

 tac ctg gca gaa ggt gat aat gtg agg ctg ggc tgc ccc tac gtc ctg      564
 Tyr Leu Ala Glu Gly Asp Asn Val Arg Leu Gly Cys Pro Tyr Val Leu
          35                  40                  45

 gac cct gag gac tat ggt ccc aat ggg ctg gac atc gag tgg atg cag      612
 Asp Pro Glu Asp Tyr Gly Pro Asn Gly Leu Asp Ile Glu Trp Met Gln
      50                  55                  60

 gtc aac tca gac ccc gcc cac cac cga gag aac gtg ttc ctt agt tac      660
 Val Asn Ser Asp Pro Ala His His Arg Glu Asn Val Phe Leu Ser Tyr
  65                  70                  75                  80

 cag gac aag agg atc aac cat ggc agc ctt ccc cat ctg cag cag agg      708
 Gln Asp Lys Arg Ile Asn His Gly Ser Leu Pro His Leu Gln Gln Arg
                  85                  90                  95

 gtc cgc ttt gca gcc tca gac cca agc cag tac gat gcc tcc atc aac      756
 Val Arg Phe Ala Ala Ser Asp Pro Ser Gln Tyr Asp Ala Ser Ile Asn
             100                 105                 110

 ctc atg aac ctg cag gta tct gat aca gcc act tat gag tgc cgg gtg      804
 Leu Met Asn Leu Gln Val Ser Asp Thr Ala Thr Tyr Glu Cys Arg Val
         115                 120                 125

 aag aag acc acc atg gcc acc cgg aag gtc att gtc act gtc caa gca      852
 Lys Lys Thr Thr Met Ala Thr Arg Lys Val Ile Val Thr Val Gln Ala
     130                 135                 140

 cga cct gca gtg ccc atg tgc tgg aca gag ggc cac atg aca tat ggc      900
 Arg Pro Ala Val Pro Met Cys Trp Thr Glu Gly His Met Thr Tyr Gly
 145                 150                 155                 160

 aac gat gtg gtg ctg aag tgc tat gcc agt ggg ggc tcc cag ccc ctc      948
 Asn Asp Val Val Leu Lys Cys Tyr Ala Ser Gly Gly Ser Gln Pro Leu
                 165                 170                 175

 tcc tac aag tgg gcc aag atc agt ggg cac cat tac ccc tat cga gct      996
 Ser Tyr Lys Trp Ala Lys Ile Ser Gly His His Tyr Pro Tyr Arg Ala
             180                 185                 190

 ggg tct tac acc tcc cag cac agc tac cac tca gag ctg tcc tac cag     1044
 Gly Ser Tyr Thr Ser Gln His Ser Tyr His Ser Glu Leu Ser Tyr Gln
         195                 200                 205

 gag tcc ttc cac agc tcc ata aac caa ggc ctg aac aat ggg gac ctg     1092
 Glu Ser Phe His Ser Ser Ile Asn Gln Gly Leu Asn Asn Gly Asp Leu
     210                 215                 220

 gtg ttg aag gat atc tcc aga gca gat gat ggg ctg tat cag tgc aca     1140
 Val Leu Lys Asp Ile Ser Arg Ala Asp Asp Gly Leu Tyr Gln Cys Thr
 225                 230                 235                 240

 gtg gcc aac aac gtg ggc tac agt gtt tgt gtg gtg gag gtg aag gtc     1188
 Val Ala Asn Asn Val Gly Tyr Ser Val Cys Val Val Glu Val Lys Val
                 245                 250                 255

 tca gac tcc cgg cgt ata ggc gtg atc atc ggc atc gtc ctg ggc tct     1236
 Ser Asp Ser Arg Arg Ile Gly Val Ile Ile Gly Ile Val Leu Gly Ser
             260                 265                 270

 ctg ctc gcg ctg ggc tgc ctg gcc gta ggc atc tgg ggg ctc gtc tgc     1284
 Leu Leu Ala Leu Gly Cys Leu Ala Val Gly Ile Trp Gly Leu Val Cys
         275                 280                 285

 tgc tgc tgc ggg ggc tcc ggg gct ggc ggc gcc cgc ggt gcc ttc ggc     1332
 Cys Cys Cys Gly Gly Ser Gly Ala Gly Gly Ala Arg Gly Ala Phe Gly
     290                 295                 300

 tac ggc aac ggc ggc ggg gtc ggc gga ggg gcc tgc ggc gac ttg gct     1380
 Tyr Gly Asn Gly Gly Gly Val Gly Gly Gly Ala Cys Gly Asp Leu Ala
 305                 310                 315                 320

 agt gag atc aga gag gac gcc gtg gcg ccc ggg tgc aag gcc agc ggg     1428
 Ser Glu Ile Arg Glu Asp Ala Val Ala Pro Gly Cys Lys Ala Ser Gly
                 325                 330                 335

 cgc ggc agc cgc gtc acc cac ctc ctg ggg tac ccg acg cag aac gtc     1476
 Arg Gly Ser Arg Val Thr His Leu Leu Gly Tyr Pro Thr Gln Asn Val
             340                 345                 350

 agc cgc tcc ctg cgc cgc aag tac gcg cct ccc ccc tgc ggc ggc ccc     1524
 Ser Arg Ser Leu Arg Arg Lys Tyr Ala Pro Pro Pro Cys Gly Gly Pro
         355                 360                 365

 gag gac gtg gcc ctg gcg ccc tgc acc gcc gcc gcc gcc tgc gaa gcg     1572
 Glu Asp Val Ala Leu Ala Pro Cys Thr Ala Ala Ala Ala Cys Glu Ala
     370                 375                 380

 ggc ccc tcc ccg gtc tac gtc aag gtc aag agc gcg gag ccg gct gac     1620
 Gly Pro Ser Pro Val Tyr Val Lys Val Lys Ser Ala Glu Pro Ala Asp
 385                 390                 395                 400

 tgc gcc gag ggg ccg gtg cag tgc aag aac ggc ctc ttg gtc tcc agc     1668
 Cys Ala Glu Gly Pro Val Gln Cys Lys Asn Gly Leu Leu Val Ser Ser
                 405                 410                 415

 cca cac tgt gaa gag cct tgt gcc cac agc tgt gca cat cct ggg ctt     1716
 Pro His Cys Glu Glu Pro Cys Ala His Ser Cys Ala His Pro Gly Leu
             420                 425                 430

 cct cca cac ctt gtc cat aaa ctg ccc ctc agc tac ctt cag acc cag     1764
 Pro Pro His Leu Val His Lys Leu Pro Leu Ser Tyr Leu Gln Thr Gln
         435                 440                 445

 gat aca gac gca gcc tcc aga aga ata aat gct cca tta gca gct ggc     1812
 Asp Thr Asp Ala Ala Ser Arg Arg Ile Asn Ala Pro Leu Ala Ala Gly
     450                 455                 460

 tgg agc tgg ctg agg ctc tgg ctg gtg act ctg gcc tct ggt gta gac     1860
 Trp Ser Trp Leu Arg Leu Trp Leu Val Thr Leu Ala Ser Gly Val Asp
 465                 470                 475                 480

 ttc cct cag gtg agt gca tgg atg aga gct cta cct tct cct gac tgc     1908
 Phe Pro Gln Val Ser Ala Trp Met Arg Ala Leu Pro Ser Pro Asp Cys
                 485                 490                 495

 cca ggc ctc agg aca aca gga gaa cag atg caa aaa cta ttg ctc aag     1956
 Pro Gly Leu Arg Thr Thr Gly Glu Gln Met Gln Lys Leu Leu Leu Lys
             500                 505                 510

 gaa aat aaa gtg aaa acg agg aaa agc aaa aga aga tct gga gag ggc     2004
 Glu Asn Lys Val Lys Thr Arg Lys Ser Lys Arg Arg Ser Gly Glu Gly
         515                 520                 525

 tct cac ctg acc aca agc atc ctg gag caa tga gtttcagg caggaagact     2055
 Ser His Leu Thr Thr Ser Ile Leu Glu Gln 
     530                 535

 catcctgagc tgagctgctt ttcttgaagt tgtgcaagaa cgtcctgttg gctggggcaa   2115

 attcagtatt tcttttcctg gccactgtgc tggagcgtga ggaaagactc tccaccctca   2175

 ctcccagatc ctgcaggagg cgtgagagcg gatggagatg gtgaggatgt ctattaatat   2235

 ggtgtttcct gcaaaacggt g                                             2256




      <210> 472
      <211> 561
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (1)..(561)

      <400> 472
  atg gac cgc ttc cgg gcg gct gtg ggc gcc gcc tgc ggc ctg gcg ctg      48
  Met Asp Arg Phe Arg Ala Ala Val Gly Ala Ala Cys Gly Leu Ala Leu
    1               5                  10                  15

 gac aca gag cct cct cca gcc cag ggc ctt ctt ctg gct gtt cct tgt       96
 Asp Thr Glu Pro Pro Pro Ala Gln Gly Leu Leu Leu Ala Val Pro Cys
              20                  25                  30

 gcc tgg gaa cat gac ttc cgc aga gtc tcc aac ctg tcc cag tat ttc      144
 Ala Trp Glu His Asp Phe Arg Arg Val Ser Asn Leu Ser Gln Tyr Phe
          35                  40                  45

 agc cca gcc tcg gtg tcc agc agc ccg gcc cgc gcg ctc ctg ctg gtc      192
 Ser Pro Ala Ser Val Ser Ser Ser Pro Ala Arg Ala Leu Leu Leu Val
      50                  55                  60

 ggc gtc gtc ctc ctg gcc tac tgg ttc ttg tcc ctg acc ctg ggc ttc      240
 Gly Val Val Leu Leu Ala Tyr Trp Phe Leu Ser Leu Thr Leu Gly Phe
  65                  70                  75                  80

 act ttc agc gtc ctg cac gtg gtg ttc ggc cgc ttc ttc tgg atc gtg      288
 Thr Phe Ser Val Leu His Val Val Phe Gly Arg Phe Phe Trp Ile Val
                  85                  90                  95

 cgg gtc gtc ctg ttt tcc atg tcc tgc gtg tac atc ctg cac aag tac      336
 Arg Val Val Leu Phe Ser Met Ser Cys Val Tyr Ile Leu His Lys Tyr
             100                 105                 110

 gag ggc gag ccg gag aac gcg gtg ctg ccg ctg tgc ttc gtg gtg gcc      384
 Glu Gly Glu Pro Glu Asn Ala Val Leu Pro Leu Cys Phe Val Val Ala
         115                 120                 125

 gtc tac ttc atg acc ggg ccc atg ggc ttc tac tgg cga agc agt ccc      432
 Val Tyr Phe Met Thr Gly Pro Met Gly Phe Tyr Trp Arg Ser Ser Pro
     130                 135                 140

 agc ggc ccc agc aac ccc agc aac ccc agc gtg gag gag aag ctg gag      480
 Ser Gly Pro Ser Asn Pro Ser Asn Pro Ser Val Glu Glu Lys Leu Glu
 145                 150                 155                 160

 cac ctg gag aag cag gtc aga ctg ctc aac atc cgt ctc aac cgg gtg      528
 His Leu Glu Lys Gln Val Arg Leu Leu Asn Ile Arg Leu Asn Arg Val
                 165                 170                 175

 ctc gag agc ctg gac cgc tcc aag gac aag tga                          561
 Leu Glu Ser Leu Asp Arg Ser Lys Asp Lys 
             180                 185





      <210> 473
      <211> 1095
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (82)..(1095)

      <400> 473
 aaaggatata taaacaactc aactgaagaa gggaagacct tcagggtagg cttcttgcca     60

 caacagaaca gcaccataac c  atg gct ttc ttc tcc cga ctg aat ctc cag     111
                          Met Ala Phe Phe Ser Arg Leu Asn Leu Gln
                            1               5                  10

 gag ggc ctc caa acc ttc ttt gtt ttg caa tgg atc cca gtc tat ata      159
 Glu Gly Leu Gln Thr Phe Phe Val Leu Gln Trp Ile Pro Val Tyr Ile
                  15                  20                  25

 ttt tta gga gct att ccc att ctc ctt ata ccc tac ttt ctg tta ttc      207
 Phe Leu Gly Ala Ile Pro Ile Leu Leu Ile Pro Tyr Phe Leu Leu Phe
              30                  35                  40

 agt aag ttc tgg ccc ttg gct gtg ctc tcc tta gcc tgg ctc acc tat      255
 Ser Lys Phe Trp Pro Leu Ala Val Leu Ser Leu Ala Trp Leu Thr Tyr
          45                  50                  55

 gat tgg aac acc cac agt caa ggt ggc agg cgt tca gct tgg gta cga      303
 Asp Trp Asn Thr His Ser Gln Gly Gly Arg Arg Ser Ala Trp Val Arg
      60                  65                  70

 aac tgg acc cta tgg aag tat ttc cga aat tac ttc cca gta aag ctg      351
 Asn Trp Thr Leu Trp Lys Tyr Phe Arg Asn Tyr Phe Pro Val Lys Leu
  75                  80                  85                  90

 gtg aag act cat gat ctt tct ccc aaa cac aac tac atc att gcc aat      399
 Val Lys Thr His Asp Leu Ser Pro Lys His Asn Tyr Ile Ile Ala Asn
                  95                 100                 105

 cac ccc cat ggc att ctc tct ttt ggt gtc ttc atc aac ttt gcc act      447
 His Pro His Gly Ile Leu Ser Phe Gly Val Phe Ile Asn Phe Ala Thr
             110                 115                 120

 gag gcc act ggc att gct cgg att ttc cca tcc atc act ccc ttt gta      495
 Glu Ala Thr Gly Ile Ala Arg Ile Phe Pro Ser Ile Thr Pro Phe Val
         125                 130                 135

 ggg acc tta gaa agg ata ttt tgg atc cca att gtg cga gaa tat gtg      543
 Gly Thr Leu Glu Arg Ile Phe Trp Ile Pro Ile Val Arg Glu Tyr Val
     140                 145                 150

 atg tca atg ggt gtg tgc cct gtg agt agc tca gcc ttg aag tac ttg      591
 Met Ser Met Gly Val Cys Pro Val Ser Ser Ser Ala Leu Lys Tyr Leu
 155                 160                 165                 170

 ctg acc cag aaa ggc tca ggc aat gcc gtg gtt att gtg gtg ggt gga      639
 Leu Thr Gln Lys Gly Ser Gly Asn Ala Val Val Ile Val Val Gly Gly
                 175                 180                 185

 gct gct gaa gct ctc ttg tgc cga cca gga gcc tcc act ctc ttc ctc      687
 Ala Ala Glu Ala Leu Leu Cys Arg Pro Gly Ala Ser Thr Leu Phe Leu
             190                 195                 200

 aag cag cgt aaa ggt ttt gtg aag atg gca ctg caa aca ggg gca tac      735
 Lys Gln Arg Lys Gly Phe Val Lys Met Ala Leu Gln Thr Gly Ala Tyr
         205                 210                 215

 ctt gtc cct tca tat tcc ttt ggt gag aac gaa gtt ttc aat cag gag      783
 Leu Val Pro Ser Tyr Ser Phe Gly Glu Asn Glu Val Phe Asn Gln Glu
     220                 225                 230

 acc ttc cct gag ggc acg tgg tta agg ttg ttc caa aaa acc ttc cag      831
 Thr Phe Pro Glu Gly Thr Trp Leu Arg Leu Phe Gln Lys Thr Phe Gln
 235                 240                 245                 250

 gac aca ttc aaa aaa atc ctg gga cta aat ttc tgt acc ttc cat ggc      879
 Asp Thr Phe Lys Lys Ile Leu Gly Leu Asn Phe Cys Thr Phe His Gly
                 255                 260                 265

 cgg ggc ttc act cgc gga tcc tgg ggc ttc ctg cct ttc aat cgg ccc      927
 Arg Gly Phe Thr Arg Gly Ser Trp Gly Phe Leu Pro Phe Asn Arg Pro
             270                 275                 280

 att acc act gtt gtt ggg gaa ccc ctt cca att ccc agg att aag agg      975
 Ile Thr Thr Val Val Gly Glu Pro Leu Pro Ile Pro Arg Ile Lys Arg
         285                 290                 295

 cca aac cag aag aca gta gac aag tat cac gca ctc tac atc agt gcc     1023
 Pro Asn Gln Lys Thr Val Asp Lys Tyr His Ala Leu Tyr Ile Ser Ala
     300                 305                 310

 ctg cgc aag ctc ttt gac caa cac aaa gtt gaa tat ggc ctc cct gag     1071
 Leu Arg Lys Leu Phe Asp Gln His Lys Val Glu Tyr Gly Leu Pro Glu
 315                 320                 325                 330

 acc caa gag ctg aca att aca taa                                     1095
 Thr Gln Glu Leu Thr Ile Thr 
                 335





      <210> 474
      <211> 937
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (44)..(811)

      <400> 474
 gaatgtgtac acgcccagct tcctgcctgt tactctccac agt  atg cga aga ata      55
                                                  Met Arg Arg Ile
                                                    1

 tcc ctg act tct agc cct gtg cgc ctt ctt ttg ttt ctg ctg ttg cta      103
 Ser Leu Thr Ser Ser Pro Val Arg Leu Leu Leu Phe Leu Leu Leu Leu
   5                  10                  15                  20

 cta ata gcc ttg gag atc atg gtt ggt ggt cac tct ctt tgc ttc aac      151
 Leu Ile Ala Leu Glu Ile Met Val Gly Gly His Ser Leu Cys Phe Asn
                  25                  30                  35

 ttc act ata aaa tca ttg tcc aga cct gga cag ccc tgg tgt gaa gcg      199
 Phe Thr Ile Lys Ser Leu Ser Arg Pro Gly Gln Pro Trp Cys Glu Ala
              40                  45                  50

 cag gtc ttc ttg aat aaa aat ctt ttc ctt cag tac aac agt gac aac      247
 Gln Val Phe Leu Asn Lys Asn Leu Phe Leu Gln Tyr Asn Ser Asp Asn
          55                  60                  65

 aac atg gtc aaa cct atg ggc ctc ctg ggg aag aag gta aat gcc acc      295
 Asn Met Val Lys Pro Met Gly Leu Leu Gly Lys Lys Val Asn Ala Thr
      70                  75                  80

 agc act tgg gga gag ttg acc caa acg ctg gga gaa gtg ggg cga gac      343
 Ser Thr Trp Gly Glu Leu Thr Gln Thr Leu Gly Glu Val Gly Arg Asp
  85                  90                  95                 100

 ctc agg atg ctc ctt tgt gac atc aaa ccc cag ata aag acc agt gat      391
 Leu Arg Met Leu Leu Cys Asp Ile Lys Pro Gln Ile Lys Thr Ser Asp
                 105                 110                 115

 cct tcc act ctg caa gtc gag atg ttt tgt caa cgt gaa gca gaa cgg      439
 Pro Ser Thr Leu Gln Val Glu Met Phe Cys Gln Arg Glu Ala Glu Arg
             120                 125                 130

 tgc act ggt gca tcc tgg cag ttc gcc acc aat gga gag aaa tcc ctc      487
 Cys Thr Gly Ala Ser Trp Gln Phe Ala Thr Asn Gly Glu Lys Ser Leu
         135                 140                 145

 ctc ttt gac gca atg aac atg acc tgg aca gta att aat cat gaa gcc      535
 Leu Phe Asp Ala Met Asn Met Thr Trp Thr Val Ile Asn His Glu Ala
     150                 155                 160

 agt aag atc aag gag aca tgg aag aaa gac aga ggg ctg gaa aag tat      583
 Ser Lys Ile Lys Glu Thr Trp Lys Lys Asp Arg Gly Leu Glu Lys Tyr
 165                 170                 175                 180

 ttc agg aag ctc tca aag gga gac tgc gat cac tgg ctc agg gaa ttc      631
 Phe Arg Lys Leu Ser Lys Gly Asp Cys Asp His Trp Leu Arg Glu Phe
                 185                 190                 195

 tta ggg cac tgg gag gca atg cca gaa ccg aca gtg tca cca gta aat      679
 Leu Gly His Trp Glu Ala Met Pro Glu Pro Thr Val Ser Pro Val Asn
             200                 205                 210

 gct tca gat atc cac tgg tct tct tct agt cta cca gat aga tgg atc      727
 Ala Ser Asp Ile His Trp Ser Ser Ser Ser Leu Pro Asp Arg Trp Ile
         215                 220                 225

 atc ctg ggg gca ttc atc ctg tta ctt tta atg gga att gtt ctc atc      775
 Ile Leu Gly Ala Phe Ile Leu Leu Leu Leu Met Gly Ile Val Leu Ile
     230                 235                 240

 tgt gtc tgg tgg caa aat ggc aga aga tcc acc tag aggt gataccacgg      825
 Cys Val Trp Trp Gln Asn Gly Arg Arg Ser Thr 
 245                 250                 255

 cggcgcagag ttgttcacct gtggtcctcg atcgctgaca gccttggctc ccactgctgt    885

 gtgttccctg agtcaagtgg aggcggagcc tgcaatgagc ggagatcgcg ct            937




      <210> 475
      <211> 417
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (61)..(219)

      <400> 475
 ttcacttcaa cttcactact tctgtagtct catcttgagt aaaagagaac ccagccaact     60
                                                                 
 atg aag ttc ctt gtc ttt gcc ttc atc ttg gct ctc atg gtt tcc atg      108
 Met Lys Phe Leu Val Phe Ala Phe Ile Leu Ala Leu Met Val Ser Met
   1               5                  10                  15

 att gga gct gat tca tct gaa gag tat ggg tat ggc cct tat cag cca      156
 Ile Gly Ala Asp Ser Ser Glu Glu Tyr Gly Tyr Gly Pro Tyr Gln Pro
              20                  25                  30

 gtt cca gaa caa cca cta tac cca caa cca tac caa cca caa tac caa      204
 Val Pro Glu Gln Pro Leu Tyr Pro Gln Pro Tyr Gln Pro Gln Tyr Gln
          35                  40                  45

 caa tat acc ttt taa tatcatcagt aactgcagga catgattatt gaggcttgat      259
 Gln Tyr Thr Phe 
      50

 tggcaaatac gacttctaca tccatattct catctttcat accatatcac actactacca    319

 ctttttgaag aatcatcaaa gagcaatgca aatgaaaaac actataattt actgtatact    379

 ctttgtttca ggatacttgc cttttcaatt gtcacttg                            417




      <210> 476
      <211> 642
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (1)..(642)

      <400> 476
  atg gcc cca gcc ttc ctg ctg ctg ctg ctg tgg cca cag ggt tgc gtc      48
  Met Ala Pro Ala Phe Leu Leu Leu Leu Leu Trp Pro Gln Gly Cys Val
    1               5                  10                  15

 tca gct ccc caa act gag agg aac att cct ttc aca cat ctg gac aac       96
 Ser Ala Pro Gln Thr Glu Arg Asn Ile Pro Phe Thr His Leu Asp Asn
              20                  25                  30

 atc ctc aag ggt gga act gtc aca act ggc caa gcc cct acc tca ggc      144
 Ile Leu Lys Gly Gly Thr Val Thr Thr Gly Gln Ala Pro Thr Ser Gly
          35                  40                  45

 cct gat gcc cct ttt acc act ggt gtg atg gtg ttc acc cca gga ctc      192
 Pro Asp Ala Pro Phe Thr Thr Gly Val Met Val Phe Thr Pro Gly Leu
      50                  55                  60

 atc acc ttg cct agg ctc tta gcc tcc acc aga cct gcc tcc aag aca      240
 Ile Thr Leu Pro Arg Leu Leu Ala Ser Thr Arg Pro Ala Ser Lys Thr
  65                  70                  75                  80

 ggc tac agc ttc act gct acc agc acc acc agc cag gga ccc agg agg      288
 Gly Tyr Ser Phe Thr Ala Thr Ser Thr Thr Ser Gln Gly Pro Arg Arg
                  85                  90                  95

 acc atg ggg tcc cag aca gtg acc gcg tct ccc agc aat gcc agg gac      336
 Thr Met Gly Ser Gln Thr Val Thr Ala Ser Pro Ser Asn Ala Arg Asp
             100                 105                 110

 tcc tct gct ggc cca gaa tcc atc tcc act aag tct ggg gac ctc agc      384
 Ser Ser Ala Gly Pro Glu Ser Ile Ser Thr Lys Ser Gly Asp Leu Ser
         115                 120                 125

 acc aga tcg ccc acc aca ggg ctc tgc ctc acc agc aga tct ctc ctc      432
 Thr Arg Ser Pro Thr Thr Gly Leu Cys Leu Thr Ser Arg Ser Leu Leu
     130                 135                 140

 aac aga cta ccc tcc atg ccc tcc atc agg cac cag gat gtt tac tcc      480
 Asn Arg Leu Pro Ser Met Pro Ser Ile Arg His Gln Asp Val Tyr Ser
 145                 150                 155                 160

 act gtg ctt ggg gtg gtg ctg acc ctc ctg gtg ctg atg ctg atc atg      528
 Thr Val Leu Gly Val Val Leu Thr Leu Leu Val Leu Met Leu Ile Met
                 165                 170                 175

 gtc tat ggg ttt tgg aag aag aga cac atg gca agc tac agc atg tgc      576
 Val Tyr Gly Phe Trp Lys Lys Arg His Met Ala Ser Tyr Ser Met Cys
             180                 185                 190

 agc gat cct tct aca cgt gac cca cct gga aga cca gag ccc tat gtg      624
 Ser Asp Pro Ser Thr Arg Asp Pro Pro Gly Arg Pro Glu Pro Tyr Val
         195                 200                 205

 gaa gtc tac ttg atc tga                                              642
 Glu Val Tyr Leu Ile 
     210





      <210> 477
      <211> 810
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (176)..(760)

      <400> 477
 ggggacctac tatccggcgc cgagccggag gggggaaacg gcccgccgcc cgcccggagc     60

 ccgcgagcaa ccccagtccc ccccacccgc gcgtggcggc gccggctccc tagccaccgc    120

 ggccccaccc tcttccggcc tcagctgtcc gggctgcttt cgcctccgcc tgtgg atg     178
                                                              Met
                                                                1

 ctg cgc ctc tcc gaa cgc aac atg aag gtg ctc ctt gcc gcc gcc ctc      226
 Leu Arg Leu Ser Glu Arg Asn Met Lys Val Leu Leu Ala Ala Ala Leu
               5                  10                  15

 atc gcg ggg tcc gtc ttc ttc ctg ctg ctg ccg gga cct tct gcg gcc      274
 Ile Ala Gly Ser Val Phe Phe Leu Leu Leu Pro Gly Pro Ser Ala Ala
          20                  25                  30

 gat gag aag aag aag ggg ccc aaa gtc acc gtc aag gtg tat ttt gac      322
 Asp Glu Lys Lys Lys Gly Pro Lys Val Thr Val Lys Val Tyr Phe Asp
      35                  40                  45

 cta cga att gga gat gaa gat gta ggc cgg gtg atc ttt ggt ctc ttc      370
 Leu Arg Ile Gly Asp Glu Asp Val Gly Arg Val Ile Phe Gly Leu Phe
  50                  55                  60                  65

 gga aag act gtt cca aaa aca gtg gat aat ttt gtg gcc tta gct aca      418
 Gly Lys Thr Val Pro Lys Thr Val Asp Asn Phe Val Ala Leu Ala Thr
                  70                  75                  80

 gga gag aaa gga ttt ggc tac aaa aac agc aaa ttc cat cgt gta atc      466
 Gly Glu Lys Gly Phe Gly Tyr Lys Asn Ser Lys Phe His Arg Val Ile
              85                  90                  95

 aag gac ttc atg atc cag ggc gga gac ttc acc agg gga gat ggc aca      514
 Lys Asp Phe Met Ile Gln Gly Gly Asp Phe Thr Arg Gly Asp Gly Thr
         100                 105                 110

 gga gga aag agc atc tac ggt gag cgc ttc ccc gat gag aac ttc aaa      562
 Gly Gly Lys Ser Ile Tyr Gly Glu Arg Phe Pro Asp Glu Asn Phe Lys
     115                 120                 125

 ctg aag cac tac ggg cct ggc tgg gtg agc atg gcc aac gca ggc aaa      610
 Leu Lys His Tyr Gly Pro Gly Trp Val Ser Met Ala Asn Ala Gly Lys
 130                 135                 140                 145

 gac acc aac ggc tcc cag ttc ttc atc acg aca gtc aag aca gcc tgg      658
 Asp Thr Asn Gly Ser Gln Phe Phe Ile Thr Thr Val Lys Thr Ala Trp
                 150                 155                 160

 cta gat ggc aag cat gtg gtg tta ggc aaa gtt cta gag ggc atg gac      706
 Leu Asp Gly Lys His Val Val Leu Gly Lys Val Leu Glu Gly Met Asp
             165                 170                 175

 ggt ggt tgc gga agg tgg aga gca cca aga cag aca gcc ggg ata aac      754
 Gly Gly Cys Gly Arg Trp Arg Ala Pro Arg Gln Thr Ala Gly Ile Asn
         180                 185                 190

 ccc tga aggatgtgat catcgcagac tgcggcaaga tcgaggtgga gaagcccttt       810
 Pro 






      <210> 478
      <211> 1896
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (335)..(1846)

      <400> 478
 tcagataacg aagatggcag caacatcctc gtagccaaaa tgtacaactg tcctttcatg     60

 tggcacctga agttcttcgc aagaggccgg gctgctttgt accttaaggg ttttagtgtg    120

 gaaagatgaa gccagaaagg cgatatgatc aaagtctata aaaccttgaa ggttatggag    180

 agagagaaca agtactgatt catcaaatct gagatgacca gaccccagga cggcccttaa    240

 agtctcgccg acctcgctga aacccgagcg cgagagggcg gtgcgcaggc ggctggggca    300

 cgtggccgcg tcgacattgg cggagaaccg agtg    atg gat gcc gag gga ggg     352
                                          Met Asp Ala Glu Gly Gly
                                            1               5

 gcg cgc ggg ggg cgg cgc ggg aag ggg agc cgc cgg gcc ccg cgg ccg      400
 Ala Arg Gly Gly Arg Arg Gly Lys Gly Ser Arg Arg Ala Pro Arg Pro
              10                  15                  20

 agg tgg acg gac gtc ccg gct cgc tgc tcc cgc cgg cgg agc gag gct      448
 Arg Trp Thr Asp Val Pro Ala Arg Cys Ser Arg Arg Arg Ser Glu Ala
          25                  30                  35

 gcc ctt tct tcg cag cgt gat tta ttt tct tct cct ttt ttt ctg aac      496
 Ala Leu Ser Ser Gln Arg Asp Leu Phe Ser Ser Pro Phe Phe Leu Asn
      40                  45                  50

 tct tct tcc agg gag agg cta gtg gta aca ggc cga gct gga tgg atg      544
 Ser Ser Ser Arg Glu Arg Leu Val Val Thr Gly Arg Ala Gly Trp Met
  55                  60                  65                  70

 ggt atg ggg aga ggg gca gga cgt tca gcc ctg gga ttc tgg ccg acc      592
 Gly Met Gly Arg Gly Ala Gly Arg Ser Ala Leu Gly Phe Trp Pro Thr
                  75                  80                  85

 ctc gcc ttc ctt ctc tgc agc ttc ccc gca gcc acc tcc ccg tgc aag      640
 Leu Ala Phe Leu Leu Cys Ser Phe Pro Ala Ala Thr Ser Pro Cys Lys
              90                  95                 100

 atc ctc aag tgc aac tct gag ttc tgg agc gcc acg tcg ggc agc cac      688
 Ile Leu Lys Cys Asn Ser Glu Phe Trp Ser Ala Thr Ser Gly Ser His
         105                 110                 115

 gcc cca gcc tca gac gac acc ccc gag ttc tgt gca gcc ttg cgc agc      736
 Ala Pro Ala Ser Asp Asp Thr Pro Glu Phe Cys Ala Ala Leu Arg Ser
     120                 125                 130

 tac gcc ctg tgc acg cgg cgg acg gcc cgc acc tgc cgg ggt gac ctg      784
 Tyr Ala Leu Cys Thr Arg Arg Thr Ala Arg Thr Cys Arg Gly Asp Leu
 135                 140                 145                 150

 gcc tac cac tcg gcc gtc cat ggc ata gag gac ctc atg agc cag cac      832
 Ala Tyr His Ser Ala Val His Gly Ile Glu Asp Leu Met Ser Gln His
                 155                 160                 165

 aac tgc tcc aag gat ggc ccc acc tcg cag cca cgc ctg cgc acg ctc      880
 Asn Cys Ser Lys Asp Gly Pro Thr Ser Gln Pro Arg Leu Arg Thr Leu
             170                 175                 180

 cca ccg gcc gga gac agc cag gag cgc tcg gac agc ccc gag atc tgc      928
 Pro Pro Ala Gly Asp Ser Gln Glu Arg Ser Asp Ser Pro Glu Ile Cys
         185                 190                 195

 cat tac gag aag agc ttt cac aag cac tcg gcc acc ccc aac tac acg      976
 His Tyr Glu Lys Ser Phe His Lys His Ser Ala Thr Pro Asn Tyr Thr
     200                 205                 210

 cac tgt ggc ctc ttc ggg gac cca cac ctc agg act ttc acc gac cgc     1024
 His Cys Gly Leu Phe Gly Asp Pro His Leu Arg Thr Phe Thr Asp Arg
 215                 220                 225                 230

 ttc cag acc tgc aag gtg cag ggc gcc tgg ccg ctc atc gac aat aat     1072
 Phe Gln Thr Cys Lys Val Gln Gly Ala Trp Pro Leu Ile Asp Asn Asn
                 235                 240                 245

 tac ctg aac gtg cag gtc acc aac acg cct gtg ctg ccc ccc tca gcg     1120
 Tyr Leu Asn Val Gln Val Thr Asn Thr Pro Val Leu Pro Pro Ser Ala
             250                 255                 260

 gcc act gcc acc agc aag ctc acc atc atc ttc aag aac ttc cag gag     1168
 Ala Thr Ala Thr Ser Lys Leu Thr Ile Ile Phe Lys Asn Phe Gln Glu
         265                 270                 275

 tgt gtg gac cag aag gtg tac cag gct gag atg gac gag ctc ccg gcc     1216
 Cys Val Asp Gln Lys Val Tyr Gln Ala Glu Met Asp Glu Leu Pro Ala
     280                 285                 290

 gcc ttc gtg gat ggc tct aag aac ggt ggg gac aag cac ggg gcc aac     1264
 Ala Phe Val Asp Gly Ser Lys Asn Gly Gly Asp Lys His Gly Ala Asn
 295                 300                 305                 310

 agc ctg aag atc act gag aag gtg tca ggc cag cac gtg gag atc cag     1312
 Ser Leu Lys Ile Thr Glu Lys Val Ser Gly Gln His Val Glu Ile Gln
                 315                 320                 325

 gcc aag tac atc ggc acc acc atc gtg gtg cgc cag gtg ggc cgc tac     1360
 Ala Lys Tyr Ile Gly Thr Thr Ile Val Val Arg Gln Val Gly Arg Tyr
             330                 335                 340

 ctg acc ttt gcc gtc cgc atg cca gag gaa gtg gtc aat gct gtg gag     1408
 Leu Thr Phe Ala Val Arg Met Pro Glu Glu Val Val Asn Ala Val Glu
         345                 350                 355

 gac tgg gac agc cag ggt ctc tac ctc tgc ctg cgg ggc tgc ccc ctc     1456
 Asp Trp Asp Ser Gln Gly Leu Tyr Leu Cys Leu Arg Gly Cys Pro Leu
     360                 365                 370

 aac cag cag atc gac ttc cag gcc ttc cac acc aat gct gag ggc acc     1504
 Asn Gln Gln Ile Asp Phe Gln Ala Phe His Thr Asn Ala Glu Gly Thr
 375                 380                 385                 390

 ggt gcc cgc agg ctg gca gcc gcc agc cct gca ccc aca gcc ccc gag     1552
 Gly Ala Arg Arg Leu Ala Ala Ala Ser Pro Ala Pro Thr Ala Pro Glu
                 395                 400                 405

 acc ttc cca tac gag aca gcc gtg gcc aag tgc aag gag aag ctg ccg     1600
 Thr Phe Pro Tyr Glu Thr Ala Val Ala Lys Cys Lys Glu Lys Leu Pro
             410                 415                 420

 gtg gag gac ctg tac tac cag gcc tgc gtc ttc gac ctc ctc acc acg     1648
 Val Glu Asp Leu Tyr Tyr Gln Ala Cys Val Phe Asp Leu Leu Thr Thr
         425                 430                 435

 ggc gac gtg aac ttc aca ctg gcc gcc tac tac gcg ttg gag gat gtc     1696
 Gly Asp Val Asn Phe Thr Leu Ala Ala Tyr Tyr Ala Leu Glu Asp Val
     440                 445                 450

 aag atg ctc cac tcc aac aaa gac aaa ctg cac ctg tat gag agg act     1744
 Lys Met Leu His Ser Asn Lys Asp Lys Leu His Leu Tyr Glu Arg Thr
 455                 460                 465                 470

 cgg gac ctg cca ggc agg gcg gct gcg ggg ctg ccc ctg gcc ccc cgg     1792
 Arg Asp Leu Pro Gly Arg Ala Ala Ala Gly Leu Pro Leu Ala Pro Arg
                 475                 480                 485

 ccc ctc ctg ggc gcc ctc gtc ccg ctc ctg gcc ctg ctc cct gtg ttc     1840
 Pro Leu Leu Gly Ala Leu Val Pro Leu Leu Ala Leu Leu Pro Val Phe
             490                 495                 500

 tgc tag acgcgtagat gtggagggag gcgcgggctc cgtcctctcg gcttccccat      1896
 Cys 






      <210> 479
      <211> 1479
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (670)..(1479)

      <400> 479
 aagcgccgca gtgatctcca cgtcttggag gccgccggca taggtgtgcg cctggcagaa     60

 cctcacaaat acacatgcac gcaggccccg actgaatcca gggctgtagg ggctaaagag    120

 gtctaggtca gtagaggcct gaagcccagg ctggtctgtc caaggaaaaa ggagcgtgat    180

 tggtaccaga tcttcgttcc ctgcagaacc ttgacagttg aacaagtgac ctcctccaga    240

 acagatggag agtctccaga agcagaggct ttagtgaacg aaattcgcaa taatcagctc    300

 cagatcctga aaaggagggc gaagaatcag tggccaaagc taaccgcttc atacccacac    360

 ttcatcctcc tcagtttctc tccaggccac catgtctgca ggcaacggca ccccttgggg    420

 tcagcagcgg gggaggaggt ctgggctgga tcaggagtgg aggtggaggg ctcagagctg    480

 cccaccttct cggcagcagc caaggtccga gtgggagtga ccattgtgct gtttgtttct    540

 tcggctggag ggaacctggc agtcctgtgg tcagtgacac ggcgggaacc cagccagctc    600

 cgcccctctc cggtcaggag actcttcatc catttagcag ccgccgactt actagtcact    660

 tttgtggtt    atg ccc cta gat gcc acc tgg aat atc act gtt caa tgg     708
              Met Pro Leu Asp Ala Thr Trp Asn Ile Thr Val Gln Trp
                1               5                  10

 ctg gct gtg gac atc gca tgt cgg aca ctg atg ttc ctg aaa cta atg      756
 Leu Ala Val Asp Ile Ala Cys Arg Thr Leu Met Phe Leu Lys Leu Met
      15                  20                  25

 gcc acg tat tct gca gct ttc ctg cct gtg gtc att gga ttg gac cgc      804
 Ala Thr Tyr Ser Ala Ala Phe Leu Pro Val Val Ile Gly Leu Asp Arg
  30                  35                  40                  45

 cag gca gca gta ctc aac ccg ctt gga tcc cgt tca ggt gta agg aaa      852
 Gln Ala Ala Val Leu Asn Pro Leu Gly Ser Arg Ser Gly Val Arg Lys
                  50                  55                  60

 ctt ctg ggg gca gcc tgg gga ctt agt ttc ctg ctt gcc ttc ccc cag      900
 Leu Leu Gly Ala Ala Trp Gly Leu Ser Phe Leu Leu Ala Phe Pro Gln
              65                  70                  75

 tgt gtc acc aaa ggc agc ttc aag gct caa tgg caa gag acc acc tat      948
 Cys Val Thr Lys Gly Ser Phe Lys Ala Gln Trp Gln Glu Thr Thr Tyr
          80                  85                  90

 aac ctc ttc acc ttc tgc tgc ctc ttt ctg ctg cca ctg act gcc atg      996
 Asn Leu Phe Thr Phe Cys Cys Leu Phe Leu Leu Pro Leu Thr Ala Met
      95                 100                 105

 gcc atc tgc tat agc cgc att gtc ctc agt gtg tcc agg ccc cag aca     1044
 Ala Ile Cys Tyr Ser Arg Ile Val Leu Ser Val Ser Arg Pro Gln Thr
 110                 115                 120                 125

 agg aag ggg agc cat gcc cct gct ggt gaa ttt gcc ctc ccc cgc tcc     1092
 Arg Lys Gly Ser His Ala Pro Ala Gly Glu Phe Ala Leu Pro Arg Ser
                 130                 135                 140

 ttt gac aat tgt ccc cgt gtt cgt ctc cgg gcc ctg aga ctg gcc ctg     1140
 Phe Asp Asn Cys Pro Arg Val Arg Leu Arg Ala Leu Arg Leu Ala Leu
             145                 150                 155

 ctt atc ttg ctg acc ttc atc ctc tgc tgg aca cct tat tac cta ctg     1188
 Leu Ile Leu Leu Thr Phe Ile Leu Cys Trp Thr Pro Tyr Tyr Leu Leu
         160                 165                 170

 ggt atg tgg tac tgg ttc tcc ccc acc atg cta act gaa gtc cct ccc     1236
 Gly Met Trp Tyr Trp Phe Ser Pro Thr Met Leu Thr Glu Val Pro Pro
     175                 180                 185

 agc ctg agc cac atc ctt ttc ctc ttg ggc ctc ctc aat gct cct ttg     1284
 Ser Leu Ser His Ile Leu Phe Leu Leu Gly Leu Leu Asn Ala Pro Leu
 190                 195                 200                 205

 gat cct ctc ctc tat ggg gcc ttc acc ctt ggc tgc cga aga ggg cac     1332
 Asp Pro Leu Leu Tyr Gly Ala Phe Thr Leu Gly Cys Arg Arg Gly His
                 210                 215                 220

 caa gaa ctt agt ata gac tct tct aaa gaa ggg tct ggg aga atg ctc     1380
 Gln Glu Leu Ser Ile Asp Ser Ser Lys Glu Gly Ser Gly Arg Met Leu
             225                 230                 235

 caa gag gag att cat gcc ttt aga cag ctg gaa gta caa aaa act gtg     1428
 Gln Glu Glu Ile His Ala Phe Arg Gln Leu Glu Val Gln Lys Thr Val
         240                 245                 250

 aca tca aga agg gca gga gaa aca aaa ggc att tct ata aca tct atc     1476
 Thr Ser Arg Arg Ala Gly Glu Thr Lys Gly Ile Ser Ile Thr Ser Ile
     255                 260                 265

 tga                                                                 1479
 






      <210> 480
      <211> 1729
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (46)..(1446)

      <400> 480
 agcgggtcgt gccacggccc cggatgttgt ggctgccgcg gggag    atg gct gag      54
                                                      Met Ala Glu
                                                        1

 gcc gaa ggg gtt ccc acg acc cca ggc ccg gct tcg ggg tcg act ttc      102
 Ala Glu Gly Val Pro Thr Thr Pro Gly Pro Ala Ser Gly Ser Thr Phe
       5                  10                  15

 agg ggc cgc cga gat gtg tca ggc tcc tgg gag cgg gac cag cag gtt      150
 Arg Gly Arg Arg Asp Val Ser Gly Ser Trp Glu Arg Asp Gln Gln Val
  20                  25                  30                  35

 gag gcg gcg cag cgg gcc ctg gtg gag gtg ctg ggg cct tac gag cct      198
 Glu Ala Ala Gln Arg Ala Leu Val Glu Val Leu Gly Pro Tyr Glu Pro
                  40                  45                  50

 ctg ctg agt cgg gtg cag gca gcc ctg gtg tgg gag cgg cca gct agg      246
 Leu Leu Ser Arg Val Gln Ala Ala Leu Val Trp Glu Arg Pro Ala Arg
              55                  60                  65

 agc gct ctg tgg tgc ctg ggg ctg aac gcg gct ttc tgg ttt ttt gcc      294
 Ser Ala Leu Trp Cys Leu Gly Leu Asn Ala Ala Phe Trp Phe Phe Ala
          70                  75                  80

 ctg aca tct ctt cgt ctt gtg ttt tta ctt gca ttt ggc ttg atg atc      342
 Leu Thr Ser Leu Arg Leu Val Phe Leu Leu Ala Phe Gly Leu Met Ile
      85                  90                  95

 att gtg tgt att gat caa tgg aag aac aaa atc tgg cct gaa ata aaa      390
 Ile Val Cys Ile Asp Gln Trp Lys Asn Lys Ile Trp Pro Glu Ile Lys
 100                 105                 110                 115

 gtg cca aga ccc gac gca tta gac aat gag agc tgg ggc ttt gtg cac      438
 Val Pro Arg Pro Asp Ala Leu Asp Asn Glu Ser Trp Gly Phe Val His
                 120                 125                 130

 cct cgg ttg ctc agc gtg ccc gag ctc tgc cac cat gta gct gaa gtc      486
 Pro Arg Leu Leu Ser Val Pro Glu Leu Cys His His Val Ala Glu Val
             135                 140                 145

 tgg gtt agt ggg acc att ttc ata agg aat gtt ttg ctt ttc aaa aag      534
 Trp Val Ser Gly Thr Ile Phe Ile Arg Asn Val Leu Leu Phe Lys Lys
         150                 155                 160

 caa aac cca ggc aag ttc tgc ttg ctg agc tgt ggg ata ctg acc ttt      582
 Gln Asn Pro Gly Lys Phe Cys Leu Leu Ser Cys Gly Ile Leu Thr Phe
     165                 170                 175

 ttg gct gtc ttg ggc cgc tac gtc cct ggg ctt ctg ctg tcc tac ttg      630
 Leu Ala Val Leu Gly Arg Tyr Val Pro Gly Leu Leu Leu Ser Tyr Leu
 180                 185                 190                 195

 atg ctt gtc act gtc atg atg tgg ccc ctt gct gtg tac cac cga ctg      678
 Met Leu Val Thr Val Met Met Trp Pro Leu Ala Val Tyr His Arg Leu
                 200                 205                 210

 tgg gat cga gca tat gtg cgg ctg aag cca gct ctg cag cgg cta gac      726
 Trp Asp Arg Ala Tyr Val Arg Leu Lys Pro Ala Leu Gln Arg Leu Asp
             215                 220                 225

 ttc agt gtc cgt ggc tac atg atg tcc aag cag aga gag aga caa tta      774
 Phe Ser Val Arg Gly Tyr Met Met Ser Lys Gln Arg Glu Arg Gln Leu
         230                 235                 240

 cgc cgc aga gct ctc cac cca gaa cga gcc atg gac aac cac agt gac      822
 Arg Arg Arg Ala Leu His Pro Glu Arg Ala Met Asp Asn His Ser Asp
     245                 250                 255

 agc gaa gag gag ctt gct gcc ttc tgt cct cag ctg gac gat tct act      870
 Ser Glu Glu Glu Leu Ala Ala Phe Cys Pro Gln Leu Asp Asp Ser Thr
 260                 265                 270                 275

 gtt gcc agg gaa ttg gcc atc aca gac tct gag cac tca gac gct gaa      918
 Val Ala Arg Glu Leu Ala Ile Thr Asp Ser Glu His Ser Asp Ala Glu
                 280                 285                 290

 gtc tcc tgt aca gac aat ggc aca ttc aat ctt tca agg ggc caa aca      966
 Val Ser Cys Thr Asp Asn Gly Thr Phe Asn Leu Ser Arg Gly Gln Thr
             295                 300                 305

 cct cta acg gaa ggc tct gaa gac cta gat ggt cac agt gat cca gag     1014
 Pro Leu Thr Glu Gly Ser Glu Asp Leu Asp Gly His Ser Asp Pro Glu
         310                 315                 320

 gaa tcc ttt gcc aga gac ctt cca gac ttc cct tcc att aat atg gat     1062
 Glu Ser Phe Ala Arg Asp Leu Pro Asp Phe Pro Ser Ile Asn Met Asp
     325                 330                 335

 cct gct ggc ctg gat gat gag gac gac act agc att ggc atg ccc agc     1110
 Pro Ala Gly Leu Asp Asp Glu Asp Asp Thr Ser Ile Gly Met Pro Ser
 340                 345                 350                 355

 ttg atg tac cgt tct ccg cca ggg gct gag gag ccc cag gcc cca cct     1158
 Leu Met Tyr Arg Ser Pro Pro Gly Ala Glu Glu Pro Gln Ala Pro Pro
                 360                 365                 370

 gcc agc cgg gac gag gct gcg ctg ccg gag ctc ctg ctt ggt gct ctt     1206
 Ala Ser Arg Asp Glu Ala Ala Leu Pro Glu Leu Leu Leu Gly Ala Leu
             375                 380                 385

 cct gta gga tcc aac ctc acc agc aac ctt gcc agc ctg gtc tcc cag     1254
 Pro Val Gly Ser Asn Leu Thr Ser Asn Leu Ala Ser Leu Val Ser Gln
         390                 395                 400

 ggt atg att cag ctg gcc ttg tca ggg gcc tcc caa cca ggc cct tct     1302
 Gly Met Ile Gln Leu Ala Leu Ser Gly Ala Ser Gln Pro Gly Pro Ser
     405                 410                 415

 gga gca cct gcc cag aga gca acg aga ggc ttc ctc cgg tcc ccc agt     1350
 Gly Ala Pro Ala Gln Arg Ala Thr Arg Gly Phe Leu Arg Ser Pro Ser
 420                 425                 430                 435

 tca gac ctg gac act gat gct gag ggg gat gac ttt gaa ctt ctg gac     1398
 Ser Asp Leu Asp Thr Asp Ala Glu Gly Asp Asp Phe Glu Leu Leu Asp
                 440                 445                 450

 cag tcg gag ctg agt cag ctg gac cct gcc agt tct agg agc cac tga     1446
 Gln Ser Glu Leu Ser Gln Leu Asp Pro Ala Ser Ser Arg Ser His 
             455                 460                 465

 ggcagagact ccttttggga gtcactgtgg tttaggtttt tttctcccca tcccacttaa   1506

 ggtgatgggg caagggaaga actcagctcc cctcccctga attatatttg tatgctgggt   1566

 ggcctggctg atgctcagag gcctccttag agaggacact cactcccctc ccaccagctg   1626

 gatgcccatt tctgagctca gtcactgaag tgagagtgtg ctcccccaag ggaggcttct   1686

 ctccatcagg atggtacaaa ggggaaacaa aatagtcagg gaa                     1729




      <210> 481
      <211> 1250
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (1)..(939)

      <400> 481
  atg atg tgc ctg gaa tgc gcc tcg gcg gcg gcg ggc ggc gcg gag gag      48
  Met Met Cys Leu Glu Cys Ala Ser Ala Ala Ala Gly Gly Ala Glu Glu
    1               5                  10                  15

 gag gag gcg gac gcg gag cgg cgg cgc cgg cgc cgg ggg gcg cag cga       96
 Glu Glu Ala Asp Ala Glu Arg Arg Arg Arg Arg Arg Gly Ala Gln Arg
              20                  25                  30

 ggg gct ggc ggt agc ggt tgc tgc ggg gcg cgg ggc gcg ggc ggc gct      144
 Gly Ala Gly Gly Ser Gly Cys Cys Gly Ala Arg Gly Ala Gly Gly Ala
          35                  40                  45

 gga gtc tcg gcc gcg ggc gat gag gtg cag acg ctg tcg ggc agc gta      192
 Gly Val Ser Ala Ala Gly Asp Glu Val Gln Thr Leu Ser Gly Ser Val
      50                  55                  60

 agg cgg gcc ccg acc gga ccc ccc ggc acc ccc ggc acc ccc ggc tgc      240
 Arg Arg Ala Pro Thr Gly Pro Pro Gly Thr Pro Gly Thr Pro Gly Cys
  65                  70                  75                  80

 gca gct act gca aag ggc ccc ggc gct cag cag ccc aaa ccg acc agc      288
 Ala Ala Thr Ala Lys Gly Pro Gly Ala Gln Gln Pro Lys Pro Thr Ser
                  85                  90                  95

 ttg ggc cgc ggg cgg ggg gca gcc gcc gcc atc ctc agc ttg ggc aac      336
 Leu Gly Arg Gly Arg Gly Ala Ala Ala Ala Ile Leu Ser Leu Gly Asn
             100                 105                 110

 gtg ctc aac tac ctg gac agg tac acc gtg gca ggc gtc ctt ctg gac      384
 Val Leu Asn Tyr Leu Asp Arg Tyr Thr Val Ala Gly Val Leu Leu Asp
         115                 120                 125

 atc cag cag cac ttt ggg gtc aag gac cga ggc gcc ggc ctg ctg cag      432
 Ile Gln Gln His Phe Gly Val Lys Asp Arg Gly Ala Gly Leu Leu Gln
     130                 135                 140

 tca gtg ttc atc tgt agc ttc atg gtg gct gcc ccc atc ttc ggc tac      480
 Ser Val Phe Ile Cys Ser Phe Met Val Ala Ala Pro Ile Phe Gly Tyr
 145                 150                 155                 160

 ctg ggc gac cgc ttc aac agg aag gtg att ctc agc tgc ggc att ttc      528
 Leu Gly Asp Arg Phe Asn Arg Lys Val Ile Leu Ser Cys Gly Ile Phe
                 165                 170                 175

 ttc tgg tcg gcc gtc acc ttc tcc agc tcc ttc att ccc cag cag tac      576
 Phe Trp Ser Ala Val Thr Phe Ser Ser Ser Phe Ile Pro Gln Gln Tyr
             180                 185                 190

 ttc tgg ctg ctg gtc ctg tcc cgg ggg ctg gtg ggc atc ggg gag gcc      624
 Phe Trp Leu Leu Val Leu Ser Arg Gly Leu Val Gly Ile Gly Glu Ala
         195                 200                 205

 agc tac tcc acc atc gcc ccc act atc att ggc gac ctc ttc acc aag      672
 Ser Tyr Ser Thr Ile Ala Pro Thr Ile Ile Gly Asp Leu Phe Thr Lys
     210                 215                 220

 aac acg cgt acg ctc atg ctg tcc gtc ttc tac ttc gcc atc cca ctg      720
 Asn Thr Arg Thr Leu Met Leu Ser Val Phe Tyr Phe Ala Ile Pro Leu
 225                 230                 235                 240

 ggc agt ggc ctg ggc tac att act ggc tcc agc gtg aag cag gca gcc      768
 Gly Ser Gly Leu Gly Tyr Ile Thr Gly Ser Ser Val Lys Gln Ala Ala
                 245                 250                 255

 gga gac tgg cac tgg gca ttg cgg gtg tcc cct gtc ctg ggc atg atc      816
 Gly Asp Trp His Trp Ala Leu Arg Val Ser Pro Val Leu Gly Met Ile
             260                 265                 270

 aca gga aca ctc atc ctc att ctg gtc cca gcc act aaa agg ggt cat      864
 Thr Gly Thr Leu Ile Leu Ile Leu Val Pro Ala Thr Lys Arg Gly His
         275                 280                 285

 gcc gac cag ctc ggg gac cag ctc aag gcc cgg acc tca tgg ctc cga      912
 Ala Asp Gln Leu Gly Asp Gln Leu Lys Ala Arg Thr Ser Trp Leu Arg
     290                 295                 300

 gat atg aag gcc ctg att cga aag tga gtacc gcgggaaggg gtctggcggg      964
 Asp Met Lys Ala Leu Ile Arg Lys 
 305                 310

 aagagagagg ggtgctgaga tgagagggcc tgtccctgca gggcagccca ctagcaccct   1024

 cagccagaca ccccacctct gctgtctcag tgctgggagg gacattttgg ccccagaatc   1084

 gattattcct gcagcctgaa ccctcacccc tggagcctgt aagacgaggc atttgggggc   1144

 ctcctgttcc cccagtgcat ggggctgcct aggggggtga aggaggtccc tgagctcagt   1204

 gtcactgcct ggcctctccc cagccgcagc tacgtcttct cggtcg                  1250




      <210> 482
      <211> 1559
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (477)..(1559)

      <400> 482
 tcagaatttt ggaaacagtg ccaggaggat cttggacata attttcaggg tgtataagcc     60

 ctgcactaaa gtaaagttta ccagtgccaa gagtttgacg ttttcttctt catgttttct    120

 ttggctggag cctggcttta gttgaagagt tctcatctcc acatttctta gccatttgtc    180

 accagactgc agattgactg gtgggatgcc tgtttctaga gagaaaagat actgcttttc    240

 tctgactcca gctgagaaga ggttggttaa attacgaatt tgatgactat ctatgaacct    300

 tctcttgatg gaagttactc cttggttgtt tttgctcaga ggcctggggg tagtgaaagc    360

 aggctgggtg actgtgggat taagtgagga gctgggttga gctgaccact ggcagtgaaa    420

 tgagtagaac ctcatagggg tacagagctg atgggaaaag cacttgggcc atcatc        476                                                                 
 atg ttc ata gat agt cat cag att cgt aat tta acc aac ctc ttc tca      524
 Met Phe Ile Asp Ser His Gln Ile Arg Asn Leu Thr Asn Leu Phe Ser
   1               5                  10                  15

 gct gga gtc aga gaa aag cag tat ctt ttc tct cta gaa aca ggc atc      572
 Ala Gly Val Arg Glu Lys Gln Tyr Leu Phe Ser Leu Glu Thr Gly Ile
              20                  25                  30

 cca cca gtc aat cta cag tct ggt gac aaa tgg cta aga aat gtg gag      620
 Pro Pro Val Asn Leu Gln Ser Gly Asp Lys Trp Leu Arg Asn Val Glu
          35                  40                  45

 atg agg tgc ctg tgg gcg ggc tcg tgc atg gac agt ccc agc aat gcc      668
 Met Arg Cys Leu Trp Ala Gly Ser Cys Met Asp Ser Pro Ser Asn Ala
      50                  55                  60

 acc gtg ccc tgt ggc ttt ctc ctt caa ggc ttc tcc gaa ttc ccg cac      716
 Thr Val Pro Cys Gly Phe Leu Leu Gln Gly Phe Ser Glu Phe Pro His
  65                  70                  75                  80

 ctg aga ccc gtg ctc ttc ctt ttg ctg ctg ggg gtg cac ctg gcc acc      764
 Leu Arg Pro Val Leu Phe Leu Leu Leu Leu Gly Val His Leu Ala Thr
                  85                  90                  95

 ctg ggc ggg aac ctg ctc atc ctg gtg gcc gtg gcc tcg atg cca agc      812
 Leu Gly Gly Asn Leu Leu Ile Leu Val Ala Val Ala Ser Met Pro Ser
             100                 105                 110

 cgg cag ccc atg ctg ctc ttc ctg tgc cag ctg tca gcc atc gag ctg      860
 Arg Gln Pro Met Leu Leu Phe Leu Cys Gln Leu Ser Ala Ile Glu Leu
         115                 120                 125

 tgc tac acg ctg gtg gtg gtg ccc cgc tcc ctg atg cag atg ttt gtg      908
 Cys Tyr Thr Leu Val Val Val Pro Arg Ser Leu Met Gln Met Phe Val
     130                 135                 140

 gct ctg ggc ggg gcc gag tgc ttc ctg ctg gcc gcc atg gcc tat gac      956
 Ala Leu Gly Gly Ala Glu Cys Phe Leu Leu Ala Ala Met Ala Tyr Asp
 145                 150                 155                 160

 cgc tac gtg gcc atc tgc cac ccg ttg cgc tac gcg gcc gtg gtg acc     1004
 Arg Tyr Val Ala Ile Cys His Pro Leu Arg Tyr Ala Ala Val Val Thr
                 165                 170                 175

 ccc ggg ctg tgc gcg cga ctg gct ctg gcc tgc tgc ctc agg gga ctg     1052
 Pro Gly Leu Cys Ala Arg Leu Ala Leu Ala Cys Cys Leu Arg Gly Leu
             180                 185                 190

 gcg gtg tcc gtg ggg ctc acg gtg gcc atc ttc cac ctg cct ttc tgc     1100
 Ala Val Ser Val Gly Leu Thr Val Ala Ile Phe His Leu Pro Phe Cys
         195                 200                 205

 ggc tcc cgc ctg ctg ctg cac ttc ttc tgc gac atc acg gcg ctg ctg     1148
 Gly Ser Arg Leu Leu Leu His Phe Phe Cys Asp Ile Thr Ala Leu Leu
     210                 215                 220

 cac ctg gcc tgc acg cgg agc tac gcc gac gag ctg cct ctg ctg ggc     1196
 His Leu Ala Cys Thr Arg Ser Tyr Ala Asp Glu Leu Pro Leu Leu Gly
 225                 230                 235                 240

 gcc tgc ctg gtg ctg ctg ctg ctg ccc tcg gtg ctc atc ctg gcc tcc     1244
 Ala Cys Leu Val Leu Leu Leu Leu Pro Ser Val Leu Ile Leu Ala Ser
                 245                 250                 255

 tat ggc gcc atc gcc gcc gcc ctg cgc cgc ctg cgc tgc ccc aaa ggc     1292
 Tyr Gly Ala Ile Ala Ala Ala Leu Arg Arg Leu Arg Cys Pro Lys Gly
             260                 265                 270

 cgg ggc aag gcc gcc tcc acc tgc gcc ttg cac ctg gca gtc acc ttc     1340
 Arg Gly Lys Ala Ala Ser Thr Cys Ala Leu His Leu Ala Val Thr Phe
         275                 280                 285

 ctg cac tac ggc tgc gcc acc ttc atg tac gtg cgg ccc agg gcc agc     1388
 Leu His Tyr Gly Cys Ala Thr Phe Met Tyr Val Arg Pro Arg Ala Ser
     290                 295                 300

 tac tcc ccg cgc ctg gac cgc acc ctg gcg ctg gtc tac acc aac gtc     1436
 Tyr Ser Pro Arg Leu Asp Arg Thr Leu Ala Leu Val Tyr Thr Asn Val
 305                 310                 315                 320

 acg ccg ctg ctg tgc cca ctc atc tac agc ctg cgc aac cgc gag atc     1484
 Thr Pro Leu Leu Cys Pro Leu Ile Tyr Ser Leu Arg Asn Arg Glu Ile
                 325                 330                 335

 acc gcc gcc ctg agc agg gtg ctg ggg cgc cgg cgg cca ggc caa gct     1532
 Thr Ala Ala Leu Ser Arg Val Leu Gly Arg Arg Arg Pro Gly Gln Ala
             340                 345                 350

 cca ggc ggg gat ctg cgc gag ctc tga                                 1559
 Pro Gly Gly Asp Leu Arg Glu Leu 
         355                 360





      <210> 483
      <211> 445
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (103)..(318)

      <400> 483
 acaaggtctt actgccttat caaatgagct agccaaaaat tctggactaa acgacccctt     60

 cacaaattta atgggaaatt ctttggcaaa tggaagggat tt   atg tcc tca atc     114
                                                  Met Ser Ser Ile
                                                    1

 ctc atg tct ctt gcc atc aga ata ggg ttg ctt att ctt gta gga tgc      162
 Leu Met Ser Leu Ala Ile Arg Ile Gly Leu Leu Ile Leu Val Gly Cys
   5                  10                  15                  20

 tgt gtc ata ccc tgt gcc cta gga tta ata caa aag ctc att gaa aca      210
 Cys Val Ile Pro Cys Ala Leu Gly Leu Ile Gln Lys Leu Ile Glu Thr
                  25                  30                  35

 gct ctc ccc aaa acc tcc ctc aat cct cct cct cct cgt tcc agt gag      258
 Ala Leu Pro Lys Thr Ser Leu Asn Pro Pro Pro Pro Arg Ser Ser Glu
              40                  45                  50

 ctt ttt ctt tta gaa gac cca agt aga ata aca gag cca aat tat gtt      306
 Leu Phe Leu Leu Glu Asp Pro Ser Arg Ile Thr Glu Pro Asn Tyr Val
          55                  60                  65

 aaa agg gtt taa aga aaaaatactg taaaatattt aacaggggga ttgttaaata      361
 Lys Arg Val 
      70

 cagtaagaaa ttcttcttca aaggttcagc ttgcttaagt ttccttgttc tttgctccct    421

 gcgaattcca ccacactggg ctag                                           445




      <210> 484
      <211> 1257
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (653)..(1108)

      <400> 484
 ctccagtcta cagtgtgaca gacttggcgt gctcctccgg ccttcgtgtt gttttatttg     60

 gggttgcttt ctaatgggaa tactggacag gtgttgaaga tttggaagta tctttgctcg    120

 gtttattgtc ccagcgaagt catcaacacg ggcgtgtttg cttcctgcgg ctgctttcac    180

 acagcagcac cgacatggcg ccaacagcag agctttcttc tcgctggctc tgcggccaca    240

 attggttatc acgtgggaac gggactcagg acccatatag acagagctga gtccatgctg    300

 gctgctccat cctgtggcct gctgggtttc actcttccac ggcatggcct ctccctagaa    360

 gcccttggtg aacacccctc tccctgtgag tctggggcag tccctgccgc ccccagccag    420

 tggctcccgc agcttcccgg tgctggctca gtcctggcaa tgaccacact gcaggctcat    480

 cttctccact ccttccccag aagctcattg atgacgtggt tctccagccg actgctgccc    540

 aggttggtgc ctgctgtagg tgacagttcc caggagagag aagcagtgtc tctgcctggg    600

 agcctgcacg caatgctggt gtgctcggcc ccttcatctg tcagctgcag ca    atg     655
                                                              Met
                                                                1

 gaa tac gtg ctg gaa gtg aag aac tct ccg cgg cac ctc ctg aag caa      703
 Glu Tyr Val Leu Glu Val Lys Asn Ser Pro Arg His Leu Leu Lys Gln
               5                  10                  15

 ttc aca gtg tgt gat gtt cct ctg tat gac att tgt gac tac aac gtc      751
 Phe Thr Val Cys Asp Val Pro Leu Tyr Asp Ile Cys Asp Tyr Asn Val
          20                  25                  30

 tcc agg gac cga tgc cag gag ctc ggg tgc tgc ttc tac gaa ggc gtc      799
 Ser Arg Asp Arg Cys Gln Glu Leu Gly Cys Cys Phe Tyr Glu Gly Val
      35                  40                  45

 tgc tac aag aaa gcg gtt ccc att tac atc cac gtg ttc tct gcc ttg      847
 Cys Tyr Lys Lys Ala Val Pro Ile Tyr Ile His Val Phe Ser Ala Leu
  50                  55                  60                  65

 att gtg atc atc gct ggg gcc ttc gtc atc acc atc atc tac aga gtc      895
 Ile Val Ile Ile Ala Gly Ala Phe Val Ile Thr Ile Ile Tyr Arg Val
                  70                  75                  80

 att cag gag agc agg aaa gaa aag gcc atc cct gtg gat gtc gcg ctg      943
 Ile Gln Glu Ser Arg Lys Glu Lys Ala Ile Pro Val Asp Val Ala Leu
              85                  90                  95

 cca cag aag tcc agc gaa aag gcg gag ttg gcc tca tcc agc agc aag      991
 Pro Gln Lys Ser Ser Glu Lys Ala Glu Leu Ala Ser Ser Ser Ser Lys
         100                 105                 110

 tta ggg ctg aag cct gcg agt cct ggg cct cca agt gct ggg ccc tcg     1039
 Leu Gly Leu Lys Pro Ala Ser Pro Gly Pro Pro Ser Ala Gly Pro Ser
     115                 120                 125

 atg aag agt gac gag gat aag gat gat gta aca ggg aca ata aca gaa     1087
 Met Lys Ser Asp Glu Asp Lys Asp Asp Val Thr Gly Thr Ile Thr Glu
 130                 135                 140                 145

 gcc gaa gaa act gag gac tga ct gagacgcatg aagaagtgga gattgtcaga     1140
 Ala Glu Glu Thr Glu Asp 
                 150

 attatccaaa tgaaatggta cagcaggtgc actgttaaca gtgtgatgga atgaccaccc   1200

 aaagagaaaa aaataaaggt attttgaaaa ttaaaaaaaa aaaaaaaaaa aaaattg      1257




      <210> 485
      <211> 450
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (1)..(450)

      <400> 485
  atg gtt act gtc act ata gcc aac tgg agg acc ttg gaa atc tca gct      48
  Met Val Thr Val Thr Ile Ala Asn Trp Arg Thr Leu Glu Ile Ser Ala
    1               5                  10                  15

 gct gct cca gtc ctc tta gga atc ctc ttc tcg ctc ttg tgt ctc aaa       96
 Ala Ala Pro Val Leu Leu Gly Ile Leu Phe Ser Leu Leu Cys Leu Lys
              20                  25                  30

 gct aat atg aaa cag cat gat ttg ttc cag ctc ctt atc cca atg tgt      144
 Ala Asn Met Lys Gln His Asp Leu Phe Gln Leu Leu Ile Pro Met Cys
          35                  40                  45

 agt ttc att ctt aca ttg gga ttt gat gca aaa gat att cac cca gga      192
 Ser Phe Ile Leu Thr Leu Gly Phe Asp Ala Lys Asp Ile His Pro Gly
      50                  55                  60

 cgt gtg aca ggg atg tgg ctc tct gtt tgg ctg ctg cta gct caa acc      240
 Arg Val Thr Gly Met Trp Leu Ser Val Trp Leu Leu Leu Ala Gln Thr
  65                  70                  75                  80

 ctt atg gga ggg gga gca caa aga tgg gca ggt gtg cga act agg ata      288
 Leu Met Gly Gly Gly Ala Gln Arg Trp Ala Gly Val Arg Thr Arg Ile
                  85                  90                  95

 aaa att gaa gct ctc atc ttc tat aac atc att ggt tct ttt gaa gca      336
 Lys Ile Glu Ala Leu Ile Phe Tyr Asn Ile Ile Gly Ser Phe Glu Ala
             100                 105                 110

 caa ctg gaa cag tta tcg act gtg att ctt gct ggg acc aat aac ctt      384
 Gln Leu Glu Gln Leu Ser Thr Val Ile Leu Ala Gly Thr Asn Asn Leu
         115                 120                 125

 cta caa ata cca aca tca gtt ttt atg aaa ggc aaa gag ctg aca ggt      432
 Leu Gln Ile Pro Thr Ser Val Phe Met Lys Gly Lys Glu Leu Thr Gly
     130                 135                 140

 tta cag act gca ccc taa                                              450
 Leu Gln Thr Ala Pro 
 145





      <210> 486
      <211> 4020
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (1)..(4020)

      <400> 486
  atg gcg cgg ggg gac gcc ggc cgc ggc cgc ggg ctc ctc gcg ttg acc      48
  Met Ala Arg Gly Asp Ala Gly Arg Gly Arg Gly Leu Leu Ala Leu Thr
    1               5                  10                  15

 ttc tgc ctg ttg gcc gcg cgc ggg acc gac cag gga agc gtg gac gag       96
 Phe Cys Leu Leu Ala Ala Arg Gly Thr Asp Gln Gly Ser Val Asp Glu
              20                  25                  30

 gtc agc agg gcc tca tcc agt ccg cag ccc agt gcg gag tgg gta cgg      144
 Val Ser Arg Ala Ser Ser Ser Pro Gln Pro Ser Ala Glu Trp Val Arg
          35                  40                  45

 gct aca cgc ccc ttc cct aag aat tca ctg aaa aat gga act cac gcc      192
 Ala Thr Arg Pro Phe Pro Lys Asn Ser Leu Lys Asn Gly Thr His Ala
      50                  55                  60

 agg cct cca cta atc cca cga aac agc att gag ctg gcc ctg gag ctc      240
 Arg Pro Pro Leu Ile Pro Arg Asn Ser Ile Glu Leu Ala Leu Glu Leu
  65                  70                  75                  80

 agc agc gaa tct cct ttc tgt ctg ggt tct aat tgg cct cat aaa atc      288
 Ser Ser Glu Ser Pro Phe Cys Leu Gly Ser Asn Trp Pro His Lys Ile
                  85                  90                  95

 cag ttt atc ctc ccc tgc atg ggt gac tca gga gca gag gct gtg gga      336
 Gln Phe Ile Leu Pro Cys Met Gly Asp Ser Gly Ala Glu Ala Val Gly
             100                 105                 110

 ggt ggg ggg aca tac act gat ggc ccc gtg ctc ctc ctc tat gca ggg      384
 Gly Gly Gly Thr Tyr Thr Asp Gly Pro Val Leu Leu Leu Tyr Ala Gly
         115                 120                 125

 gag ctg ctg ttg ccc cag gag acg act gtg gag ctg agc tgt gga gtg      432
 Glu Leu Leu Leu Pro Gln Glu Thr Thr Val Glu Leu Ser Cys Gly Val
     130                 135                 140

 ggg cca ctg caa gtg atc ctg ggc cca gag cag gct gca gtg cta aac      480
 Gly Pro Leu Gln Val Ile Leu Gly Pro Glu Gln Ala Ala Val Leu Asn
 145                 150                 155                 160

 tgt agc ctg ggg gct gct gcc gct gga ccc ccc acc agg gtg acc tgg      528
 Cys Ser Leu Gly Ala Ala Ala Ala Gly Pro Pro Thr Arg Val Thr Trp
                 165                 170                 175

 agc aag gat ggg gac acc ctg ctg gag cac gac cac tta cac ctg ctg      576
 Ser Lys Asp Gly Asp Thr Leu Leu Glu His Asp His Leu His Leu Leu
             180                 185                 190

 ccc aat ggt tcc ctg tgg ctg tcc cag cca cta gca ccc aat ggc agt      624
 Pro Asn Gly Ser Leu Trp Leu Ser Gln Pro Leu Ala Pro Asn Gly Ser
         195                 200                 205

 gac gag tca gtc cct gag gct gtg ggg gtc att gaa ggc aac tat tcg      672
 Asp Glu Ser Val Pro Glu Ala Val Gly Val Ile Glu Gly Asn Tyr Ser
     210                 215                 220

 tgc cta gcc cac ggc ccc ctc gga gtg ctg gcc agc cag act gct gtc      720
 Cys Leu Ala His Gly Pro Leu Gly Val Leu Ala Ser Gln Thr Ala Val
 225                 230                 235                 240

 gtc aag ctt gcc aca ctc gca gac ttc tct ctg cac ccg gag tct cag      768
 Val Lys Leu Ala Thr Leu Ala Asp Phe Ser Leu His Pro Glu Ser Gln
                 245                 250                 255

 acg gtg gag gag aac ggg aca gct cgc ttt gag tgc cac att gaa ggg      816
 Thr Val Glu Glu Asn Gly Thr Ala Arg Phe Glu Cys His Ile Glu Gly
             260                 265                 270

 ctg cca gct ccc atc att act tgg gag aag gac cag gtg aca ttg cct      864
 Leu Pro Ala Pro Ile Ile Thr Trp Glu Lys Asp Gln Val Thr Leu Pro
         275                 280                 285

 gag gag cct cgg ctc atc gtg ctt ccc aac ggc gtc ctt cag atc ctg      912
 Glu Glu Pro Arg Leu Ile Val Leu Pro Asn Gly Val Leu Gln Ile Leu
     290                 295                 300

 gat gtt cag gag agt gat gca ggc ccc tac cgc tgc gtg gcc acc aac      960
 Asp Val Gln Glu Ser Asp Ala Gly Pro Tyr Arg Cys Val Ala Thr Asn
 305                 310                 315                 320

 tca gct cgc cag cac ttc agc cag gag gcc cta ctc agt gtg gcc cac     1008
 Ser Ala Arg Gln His Phe Ser Gln Glu Ala Leu Leu Ser Val Ala His
                 325                 330                 335

 aga ggg tcc ctg gcg tcc acc agg ggg cag gac gtg gtc att gtg gca     1056
 Arg Gly Ser Leu Ala Ser Thr Arg Gly Gln Asp Val Val Ile Val Ala
             340                 345                 350

 gcc cca gag aac acc aca gtg gtg tct ggc cag agt gtg gtg atg gaa     1104
 Ala Pro Glu Asn Thr Thr Val Val Ser Gly Gln Ser Val Val Met Glu
         355                 360                 365

 tgt gtg gcc tca gct gac ccc acc cct ttt gtg tcc tgg gtc cga caa     1152
 Cys Val Ala Ser Ala Asp Pro Thr Pro Phe Val Ser Trp Val Arg Gln
     370                 375                 380

 gac ggg aag ccc atc tcc aca gat gtc atc gtc ctg ggc cgc acc aac     1200
 Asp Gly Lys Pro Ile Ser Thr Asp Val Ile Val Leu Gly Arg Thr Asn
 385                 390                 395                 400

 cta cta att gcc aac gcg cag ccc tgg cac tcc ggc gtc tat gtc tgc     1248
 Leu Leu Ile Ala Asn Ala Gln Pro Trp His Ser Gly Val Tyr Val Cys
                 405                 410                 415

 cgc gcc aac aag ccc cgc acg cgc gac ttc gcc act gca gcc gct gag     1296
 Arg Ala Asn Lys Pro Arg Thr Arg Asp Phe Ala Thr Ala Ala Ala Glu
             420                 425                 430

 ctc cgt gtg ctg gcg gct ccc gcc atc act cag gcg ccc gag gcg ctg     1344
 Leu Arg Val Leu Ala Ala Pro Ala Ile Thr Gln Ala Pro Glu Ala Leu
         435                 440                 445

 tcg cgg acg cgg gcg agc aca gcg cgc ttc gtg tgc cgc gcg tcg ggg     1392
 Ser Arg Thr Arg Ala Ser Thr Ala Arg Phe Val Cys Arg Ala Ser Gly
     450                 455                 460

 gag ccg cgg cca gcg ctg cgc tgg ctg cac aac ggg gcg ccg ctg cgg     1440
 Glu Pro Arg Pro Ala Leu Arg Trp Leu His Asn Gly Ala Pro Leu Arg
 465                 470                 475                 480

 ccc aac ggg cgc gtc aag gtc cag ggc ggc ggt ggc agc ctg gtc atc     1488
 Pro Asn Gly Arg Val Lys Val Gln Gly Gly Gly Gly Ser Leu Val Ile
                 485                 490                 495

 aca cag atc ggc ctg cag gac gcc ggc tac tac cag tgc gtg gct gag     1536
 Thr Gln Ile Gly Leu Gln Asp Ala Gly Tyr Tyr Gln Cys Val Ala Glu
             500                 505                 510

 aac agc gcg gga atg gcg tgc gct gcc gcg tcg ctg gcc gtg gtg gtg     1584
 Asn Ser Ala Gly Met Ala Cys Ala Ala Ala Ser Leu Ala Val Val Val
         515                 520                 525

 cgc gag ggg ctg ccc agc gcc ccc acg cgg gtc act gct acg cca ctg     1632
 Arg Glu Gly Leu Pro Ser Ala Pro Thr Arg Val Thr Ala Thr Pro Leu
     530                 535                 540

 agc agc tcc gct gtg ttg gtg gcc tgg gag cgg ccc gag atg cac agc     1680
 Ser Ser Ser Ala Val Leu Val Ala Trp Glu Arg Pro Glu Met His Ser
 545                 550                 555                 560

 gag cag atc atc ggc ttc tct ctc cac tac cag aag gca cgg ggc atg     1728
 Glu Gln Ile Ile Gly Phe Ser Leu His Tyr Gln Lys Ala Arg Gly Met
                 565                 570                 575

 gac aat gtg gaa tac cag ttt gca gtg aac aac gac acc aca gaa cta     1776
 Asp Asn Val Glu Tyr Gln Phe Ala Val Asn Asn Asp Thr Thr Glu Leu
             580                 585                 590

 cag gtt cgg gac ctg gaa ccc aac aca gat tat gag ttc tac gtg gtg     1824
 Gln Val Arg Asp Leu Glu Pro Asn Thr Asp Tyr Glu Phe Tyr Val Val
         595                 600                 605

 gcc tac tcc cag ctg gga gcc agc cgc acc tcc acc cca gca ctg gtg     1872
 Ala Tyr Ser Gln Leu Gly Ala Ser Arg Thr Ser Thr Pro Ala Leu Val
     610                 615                 620

 cac aca ctg gat gat gtc ccc agt gca gca ccc cag ctc tcc ctg tcc     1920
 His Thr Leu Asp Asp Val Pro Ser Ala Ala Pro Gln Leu Ser Leu Ser
 625                 630                 635                 640

 agc ccc aac cct tcg gac atc agg gtg gcg tgg ctg ccc ctg ccc ccc     1968
 Ser Pro Asn Pro Ser Asp Ile Arg Val Ala Trp Leu Pro Leu Pro Pro
                 645                 650                 655

 agc ctg agc aat ggg cag gtg gtg aag tac aag ata gaa tac ggt ttg     2016
 Ser Leu Ser Asn Gly Gln Val Val Lys Tyr Lys Ile Glu Tyr Gly Leu
             660                 665                 670

 gga aag gaa gat cag att ttc tct act gag gtg cga gga aat gag aca     2064
 Gly Lys Glu Asp Gln Ile Phe Ser Thr Glu Val Arg Gly Asn Glu Thr
         675                 680                 685

 cag ctt atg ctg aac tcg ctt cag cca aac aag gtg tat cga gta cgg     2112
 Gln Leu Met Leu Asn Ser Leu Gln Pro Asn Lys Val Tyr Arg Val Arg
     690                 695                 700

 att tcg gct ggt aca gca gcc ggc ttc ggg gcc ccc tcc cag tgg atg     2160
 Ile Ser Ala Gly Thr Ala Ala Gly Phe Gly Ala Pro Ser Gln Trp Met
 705                 710                 715                 720

 cat cac agg acg ccc agt atg cac aac cag agc cat gtc cct ttt gcc     2208
 His His Arg Thr Pro Ser Met His Asn Gln Ser His Val Pro Phe Ala
                 725                 730                 735

 cct gca gag ttg aag gtg cag gca aag atg gag tcc ctg gtc gtg tca     2256
 Pro Ala Glu Leu Lys Val Gln Ala Lys Met Glu Ser Leu Val Val Ser
             740                 745                 750

 tgg cag cca ccc cct cac ccc acc cag atc tct ggc tac aaa cta tat     2304
 Trp Gln Pro Pro Pro His Pro Thr Gln Ile Ser Gly Tyr Lys Leu Tyr
         755                 760                 765

 tgg cgg gag gtg ggg gct gag gag gag gcc aat ggc gat cgc ctg cca     2352
 Trp Arg Glu Val Gly Ala Glu Glu Glu Ala Asn Gly Asp Arg Leu Pro
     770                 775                 780

 ggg ggc cgt gga gac cag gct tgg gat gtg ggg cct gtc cgg ctc aag     2400
 Gly Gly Arg Gly Asp Gln Ala Trp Asp Val Gly Pro Val Arg Leu Lys
 785                 790                 795                 800

 aag aaa gtg aag cag tat gag ctg acc cag cta gtc cct ggc cgg ctg     2448
 Lys Lys Val Lys Gln Tyr Glu Leu Thr Gln Leu Val Pro Gly Arg Leu
                 805                 810                 815

 tac gag gtg aag ctc gtg gct ttc aac aaa cat gag gat ggc tat gca     2496
 Tyr Glu Val Lys Leu Val Ala Phe Asn Lys His Glu Asp Gly Tyr Ala
             820                 825                 830

 gca gtg tgg aag ggc aag acg gag aag gcg ccg gca cca gac atg cct     2544
 Ala Val Trp Lys Gly Lys Thr Glu Lys Ala Pro Ala Pro Asp Met Pro
         835                 840                 845

 atc cag agg gga cca ccc ctg cct cca gcc cac gtc cat gcg gaa tca     2592
 Ile Gln Arg Gly Pro Pro Leu Pro Pro Ala His Val His Ala Glu Ser
     850                 855                 860

 aac agc tcc aca tcc atc tgg ctt cgg tgg aaa aag cca gat ttc acc     2640
 Asn Ser Ser Thr Ser Ile Trp Leu Arg Trp Lys Lys Pro Asp Phe Thr
 865                 870                 875                 880

 aca gtc aag att gtc aac tac act gtg cgc ttc agc ccc tgg ggg ctc     2688
 Thr Val Lys Ile Val Asn Tyr Thr Val Arg Phe Ser Pro Trp Gly Leu
                 885                 890                 895

 agg aat gcc tcc ctg gtc acc tat tac acc agt tct gga gaa gac atc     2736
 Arg Asn Ala Ser Leu Val Thr Tyr Tyr Thr Ser Ser Gly Glu Asp Ile
             900                 905                 910

 ctc att ggc ggc ttg aag cca ttc acc aaa tac gag ttt gca gtg cag     2784
 Leu Ile Gly Gly Leu Lys Pro Phe Thr Lys Tyr Glu Phe Ala Val Gln
         915                 920                 925

 tct cac ggc gtg gac atg gat ggg cct ttc ggc tct gtg gtg gag cgc     2832
 Ser His Gly Val Asp Met Asp Gly Pro Phe Gly Ser Val Val Glu Arg
     930                 935                 940

 tcc acc ctg cct gac cgg ccc tcc aca ccc cca tcc gac ctg cga ctg     2880
 Ser Thr Leu Pro Asp Arg Pro Ser Thr Pro Pro Ser Asp Leu Arg Leu
 945                 950                 955                 960

 agc ccc ctg aca ccg tcc acg gtt cgg ctg cac tgg tgc ccc ccc aca     2928
 Ser Pro Leu Thr Pro Ser Thr Val Arg Leu His Trp Cys Pro Pro Thr
                 965                 970                 975

 gag ccc aac ggg gag atc gtg gag tat ctg atc ctg tac agc agc aac     2976
 Glu Pro Asn Gly Glu Ile Val Glu Tyr Leu Ile Leu Tyr Ser Ser Asn
             980                 985                 990

 cac acg cag cct gag cac cag tgg acc ttg ctc acc acg cag gga aac     3024
 His Thr Gln Pro Glu His Gln Trp Thr Leu Leu Thr Thr Gln Gly Asn
         995                1000                1005

 atc ttc agt gct gag gtc cat ggc ctg gag agc gac act cgg tac ttc     3072
 Ile Phe Ser Ala Glu Val His Gly Leu Glu Ser Asp Thr Arg Tyr Phe
    1010                1015                1020

 ttc aag atg ggg gcg cgc aca gag gtg gga cct ggg cct ttc tcc cgc     3120
 Phe Lys Met Gly Ala Arg Thr Glu Val Gly Pro Gly Pro Phe Ser Arg
1025                1030                1035                1040

 ctg cag gat gtg atc acg ctc cag gag aag ctg tca gac tcg ctg gac     3168
 Leu Gln Asp Val Ile Thr Leu Gln Glu Lys Leu Ser Asp Ser Leu Asp
                1045                1050                1055

 atg cac tca gtc acg ggc atc atc gtg ggt gtc tgc ctg ggc ctc ctc     3216
 Met His Ser Val Thr Gly Ile Ile Val Gly Val Cys Leu Gly Leu Leu
            1060                1065                1070

 tgc ctc ctg gcc tgc atg tgt gct ggc ctg cgc cgc agc ccc cac agg     3264
 Cys Leu Leu Ala Cys Met Cys Ala Gly Leu Arg Arg Ser Pro His Arg
        1075                1080                1085

 gaa tcc ctc cca ggc ctg tcc tcc acc gcc acc ccc ggg aat ccc gcg     3312
 Glu Ser Leu Pro Gly Leu Ser Ser Thr Ala Thr Pro Gly Asn Pro Ala
    1090                1095                1100

 ctg tac tcc aga gct cgg ctt ggc ccc ccc agc ccc cca gct gcc cat     3360
 Leu Tyr Ser Arg Ala Arg Leu Gly Pro Pro Ser Pro Pro Ala Ala His
1105                1110                1115                1120

 gaa ttg gag tcc ctt gtg cac ccc cat ccc cag gac tgg tcc ccg cca     3408
 Glu Leu Glu Ser Leu Val His Pro His Pro Gln Asp Trp Ser Pro Pro
                1125                1130                1135

 ccc tca gac gtg gag gac agg gct gaa gtg cac agc ctt atg ggt ggc     3456
 Pro Ser Asp Val Glu Asp Arg Ala Glu Val His Ser Leu Met Gly Gly
            1140                1145                1150

 ggt gtt tct gaa ggc cgg agt cac tcc aaa aga aag atc tcc tgg gct     3504
 Gly Val Ser Glu Gly Arg Ser His Ser Lys Arg Lys Ile Ser Trp Ala
        1155                1160                1165

 caa cca agc ggg ctg agc tgg gct ggt tcc tgg gca ggc tgt gag ctg     3552
 Gln Pro Ser Gly Leu Ser Trp Ala Gly Ser Trp Ala Gly Cys Glu Leu
    1170                1175                1180

 ccc cag gca ggc ccc cgg ccg gct ctg acc cgg gcc ctg ctg ccc cct     3600
 Pro Gln Ala Gly Pro Arg Pro Ala Leu Thr Arg Ala Leu Leu Pro Pro
1185                1190                1195                1200

 gct gga act ggg cag acg ctg ttg ctg cag gct ctg gtg tac gac gcc     3648
 Ala Gly Thr Gly Gln Thr Leu Leu Leu Gln Ala Leu Val Tyr Asp Ala
                1205                1210                1215

 ata aag gtc agc gtc ctg gaa gga agg ggc agg aaa gga gga aag ggt     3696
 Ile Lys Val Ser Val Leu Glu Gly Arg Gly Arg Lys Gly Gly Lys Gly
            1220                1225                1230

 ctt ggc cac tct gct gaa ctg gca ttt gct gtg gag cca agt gat gat     3744
 Leu Gly His Ser Ala Glu Leu Ala Phe Ala Val Glu Pro Ser Asp Asp
        1235                1240                1245

 gtt gcc gtc ccc ggg cag cct ata gtg ctg gac tgc agg gtg gag ggg     3792
 Val Ala Val Pro Gly Gln Pro Ile Val Leu Asp Cys Arg Val Glu Gly
    1250                1255                1260

 acc cct cca gtg cga atc acc tgg agg aag aat ggg gta gag ctg cca     3840
 Thr Pro Pro Val Arg Ile Thr Trp Arg Lys Asn Gly Val Glu Leu Pro
1265                1270                1275                1280

 gag agt acc cac tcc acc ttg ctg gcc aat ggg tcc ttg atg atc cgt     3888
 Glu Ser Thr His Ser Thr Leu Leu Ala Asn Gly Ser Leu Met Ile Arg
                1285                1290                1295

 cac ttc agg ctg gag ccg gga ggc agc cct tcg gat gaa ggt gac tat     3936
 His Phe Arg Leu Glu Pro Gly Gly Ser Pro Ser Asp Glu Gly Asp Tyr
            1300                1305                1310

 gag tgt gtg gcc cag aac cgc ttt ggg ctg gtg gtc agc cgg aag gct     3984
 Glu Cys Val Ala Gln Asn Arg Phe Gly Leu Val Val Ser Arg Lys Ala
        1315                1320                1325

 cgc atc caa gct gca aaa gag aaa act gag cct tag                     4020
 Arg Ile Gln Ala Ala Lys Glu Lys Thr Glu Pro 
    1330                1335





      <210> 487
      <211> 1394
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (73)..(1320)

      <400> 487
 agaatgacca gctaggcttc cctggaggcc aggcctccct ggactgggcc aggtgccttc     60

 ctgccagcaa ag    atg agt aat gtc tca ggg atc ctg gag aca gcc ggc     108
                  Met Ser Asn Val Ser Gly Ile Leu Glu Thr Ala Gly
                    1               5                  10

 gtc ccc ctg gtg tca gtg aac tgg ccg cag ccc agc ccc cca ccg gct      156
 Val Pro Leu Val Ser Val Asn Trp Pro Gln Pro Ser Pro Pro Pro Ala
          15                  20                  25

 gtg cca gct ggg ccg cag atg gac cac atg ggg aac agc tcc cag ggg      204
 Val Pro Ala Gly Pro Gln Met Asp His Met Gly Asn Ser Ser Gln Gly
      30                  35                  40

 gcc ccc tgg ctc ttc ctc acc tcc gca ctg gcc cga ggc gtc tcg ggg      252
 Ala Pro Trp Leu Phe Leu Thr Ser Ala Leu Ala Arg Gly Val Ser Gly
  45                  50                  55                  60

 atc ttc gtg tgg act gcc ctg gtg ctc acc tgc cac cag atc tat ctg      300
 Ile Phe Val Trp Thr Ala Leu Val Leu Thr Cys His Gln Ile Tyr Leu
                  65                  70                  75

 cac ctg cgc tcc tac acc gtg cca cag gag caa cgt tac atc atc cgc      348
 His Leu Arg Ser Tyr Thr Val Pro Gln Glu Gln Arg Tyr Ile Ile Arg
              80                  85                  90

 ctg ctc ctc atc gtg ccc atc tac gcc ttc gac tcc tgg ctc agc ctc      396
 Leu Leu Leu Ile Val Pro Ile Tyr Ala Phe Asp Ser Trp Leu Ser Leu
          95                 100                 105

 ctc ctc ctc gga gac cac cag tac tac gtc tac ttc gac tct gtg cgg      444
 Leu Leu Leu Gly Asp His Gln Tyr Tyr Val Tyr Phe Asp Ser Val Arg
     110                 115                 120

 gac tgc tac gaa gcc ttt gtc att tac agc ttc ctg agc ctg tgt ttc      492
 Asp Cys Tyr Glu Ala Phe Val Ile Tyr Ser Phe Leu Ser Leu Cys Phe
 125                 130                 135                 140

 cag tac ctg gga ggc gag ggc gcc atc atg gct gag att cgt gga aag      540
 Gln Tyr Leu Gly Gly Glu Gly Ala Ile Met Ala Glu Ile Arg Gly Lys
                 145                 150                 155

 ccc atc aag tcc agc tgc ttg tac ggc acc tgc tgc ctc cgg ggc atg      588
 Pro Ile Lys Ser Ser Cys Leu Tyr Gly Thr Cys Cys Leu Arg Gly Met
             160                 165                 170

 acc tac tcc atc ggg ttc ctg cgc ttc tgt aag cag gcc act ctg cag      636
 Thr Tyr Ser Ile Gly Phe Leu Arg Phe Cys Lys Gln Ala Thr Leu Gln
         175                 180                 185

 ttc tgc ctg gtg aag ccc gtc atg gcc gtc acc acc atc atc ctc cag      684
 Phe Cys Leu Val Lys Pro Val Met Ala Val Thr Thr Ile Ile Leu Gln
     190                 195                 200

 gca ttt ggc aaa tac cac gac ggg gac ttc aat gtc cgc agc ggc tac      732
 Ala Phe Gly Lys Tyr His Asp Gly Asp Phe Asn Val Arg Ser Gly Tyr
 205                 210                 215                 220

 ctc tat gtg acc ctc atc tac aac gcc tcc gtc agc ctc gcc ctc tac      780
 Leu Tyr Val Thr Leu Ile Tyr Asn Ala Ser Val Ser Leu Ala Leu Tyr
                 225                 230                 235

 gcc ctg ttc ctc ttc tac ttc acc acc agg gag ctc ctg cgg ccc ttc      828
 Ala Leu Phe Leu Phe Tyr Phe Thr Thr Arg Glu Leu Leu Arg Pro Phe
             240                 245                 250

 cag ccc gtc ctc aag ttc ctc acc atc aaa gcc gtc atc ttc ctg tcg      876
 Gln Pro Val Leu Lys Phe Leu Thr Ile Lys Ala Val Ile Phe Leu Ser
         255                 260                 265

 ttc tgg caa ggg ctg ctg ctg gcc atc ctg gag cgg tgc ggg gtc atc      924
 Phe Trp Gln Gly Leu Leu Leu Ala Ile Leu Glu Arg Cys Gly Val Ile
     270                 275                 280

 ccg gag gtg gag acc agc ggc ggg aac aag ctg ggg gct ggc acg ctg      972
 Pro Glu Val Glu Thr Ser Gly Gly Asn Lys Leu Gly Ala Gly Thr Leu
 285                 290                 295                 300

 gcc gcc ggc tac cag aac ttc atc atc tgc gtg gag atg ctg ttc gcc     1020
 Ala Ala Gly Tyr Gln Asn Phe Ile Ile Cys Val Glu Met Leu Phe Ala
                 305                 310                 315

 tcc gtg gcc ctg cgt tat gcc ttc ccc tgc cag gtg tac gca gag aag     1068
 Ser Val Ala Leu Arg Tyr Ala Phe Pro Cys Gln Val Tyr Ala Glu Lys
             320                 325                 330

 aag gag aat tca cca gcc ccc ccg gca ccc atg cag agc atc tcc agc     1116
 Lys Glu Asn Ser Pro Ala Pro Pro Ala Pro Met Gln Ser Ile Ser Ser
         335                 340                 345

 ggc atc agg gag aca gtg agc ccc cag gac atc gtg cag gac gcc atc     1164
 Gly Ile Arg Glu Thr Val Ser Pro Gln Asp Ile Val Gln Asp Ala Ile
     350                 355                 360

 cac aac ttc tcc ccc gcc tac cag cac tac acg cag cag gcc acg cac     1212
 His Asn Phe Ser Pro Ala Tyr Gln His Tyr Thr Gln Gln Ala Thr His
 365                 370                 375                 380

 gag gcg ccc acg tgt ctc cac acg cca gcc aca ggg gag ccc tgg cca     1260
 Glu Ala Pro Thr Cys Leu His Thr Pro Ala Thr Gly Glu Pro Trp Pro
                 385                 390                 395

 ggc gcc cag cca ggg gag cgt gtg cct ggg atg ggt cac aga acc agc     1308
 Gly Ala Gln Pro Gly Glu Arg Val Pro Gly Met Gly His Arg Thr Ser
             400                 405                 410

 ggg cac ctg tga ggc tggccagcac ggtggggctg tgggaatcgc tctcccccat     1363
 Gly His Leu 
         415

 atttaaaccc cttggatttt caaaaaaaaa a                                  1394




      <210> 488
      <211> 678
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (80)..(442)

      <400> 488
 caccattatt gtgcatctag ttccccggag ggccagcaca gtggccacca gcacccacag     60

 aaccacagtg ccctcaacg atg aca ccc atg ctc gtg aca gac aca gag gct     112
                      Met Thr Pro Met Leu Val Thr Asp Thr Glu Ala
                        1               5                  10

 ttc tgg cag cca cag ccc tgg ttt gtg gtg gtg ttg aca gca act ggt      160
 Phe Trp Gln Pro Gln Pro Trp Phe Val Val Val Leu Thr Ala Thr Gly
              15                  20                  25

 gct ctt ctc ctc ttg gcc cta ggc tgg ctt ctt ggc agg ctc ctc cag      208
 Ala Leu Leu Leu Leu Ala Leu Gly Trp Leu Leu Gly Arg Leu Leu Gln
          30                  35                  40

 ggg ttg gcc cag ctg ctg caa gca ccc agc aaa cca gcc cag gct ttg      256
 Gly Leu Ala Gln Leu Leu Gln Ala Pro Ser Lys Pro Ala Gln Ala Leu
      45                  50                  55

 ctg cta aac agc atc cag gga act gag gga tcc atc gag ggt ttc ctg      304
 Leu Leu Asn Ser Ile Gln Gly Thr Glu Gly Ser Ile Glu Gly Phe Leu
  60                  65                  70                  75

 gag gca ccg aag atg gag atg tcc cag gca ccc agc agt gtc atg agt      352
 Glu Ala Pro Lys Met Glu Met Ser Gln Ala Pro Ser Ser Val Met Ser
                  80                  85                  90

 ctg cag cat ttt gat ggc aga gca cag gac tcc cgt acc gga aga gac      400
 Leu Gln His Phe Asp Gly Arg Ala Gln Asp Ser Arg Thr Gly Arg Asp
              95                 100                 105

 tac ctg ttt aac aca cac aca gga gcc cgg cgc tgg ctc tga ggccaag      449
 Tyr Leu Phe Asn Thr His Thr Gly Ala Arg Arg Trp Leu 
         110                 115                 120

 tagctgtctt actatgtgtg gaatttcttt ttcacaccat catgggctgt attttcaagt    509

 tgattcataa taaacaaaat tacaaaaaga aaaaaaaaaa aaaaaggggg ggcggtttta    569

 agggatcaag ttttacttcc ggggtgaggc aaggtcttag ttttttttta gggtccctta    629

 atttaattcc tctggcgggg gtttaacacg gcctgactgg gaaaaccct                678




      <210> 489
      <211> 745
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (549)..(698)

      <400> 489
 atatgagatt aagatatttt gcactagttg tctattttct cattgaaaac caatatggca     60

 ttcttatgtt aaacacaaag ttttataact aaataactcc tgaaatagga ataacagagt    120

 atactatctt tttatttcat aaaagtagtc attttagtga ctaagaaatc aaaataaaat    180

 atcgctctgt tcgctacaaa tgaaattctc aaatacaaag ctatgtccta agataattct    240

 gatttgagat ttttcaagca attgaatttt cataggtatt cattagatat ttatattcaa    300

 cgtctagtat aagaatatga caatgccccc cacttactag aggtatgacc ttggatcagt    360

 tgcttaaact ttctccagct cagtttcttt atttgtaaga tgaggctagt aactgtttct    420

 ccttgatagg gttattataa gatcatatga gtaaaataca tagcaccgta tttagaatat    480

 agtaaacaaa caattattgt attctataac tgatatttct ttacatatcc cccaactccc    540

 atttttaa atg cct gta tgt gta tta caa ctt aat aat tgt ttg ggt gcc     590
          Met Pro Val Cys Val Leu Gln Leu Asn Asn Cys Leu Gly Ala
            1               5                  10

 tac tgt gta atc agc agc ttt ttt aca aat aca ttt ctt ctc ctt aat      638
 Tyr Cys Val Ile Ser Ser Phe Phe Thr Asn Thr Phe Leu Leu Leu Asn
  15                  20                  25                  30

 gca gtc att aat ttc ctg tat tta gga tat ctt gga ttc agt gag tcc      686
 Ala Val Ile Asn Phe Leu Tyr Leu Gly Tyr Leu Gly Phe Ser Glu Ser
                  35                  40                  45

 cca cat aaa taa tta aggtcaaaaa taaggagata gccttcccat ttgccatgac      741
 Pro His Lys 


 tact                                                                 745




      <210> 490
      <211> 438
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (36)..(269)

      <400> 490
 catggctgtg tctgtgtata tgcacttaca tatac   atg tgg gtg tat gcg tgt      53
                                          Met Trp Val Tyr Ala Cys
                                            1               5

 gta ttc atg cgt gta ttc atg tgt gtg cat ggg tgt gtg tcc gtg tat      101
 Val Phe Met Arg Val Phe Met Cys Val His Gly Cys Val Ser Val Tyr
              10                  15                  20

 atg cac tta cac ata cat ggg ggt gta tgt att cat atg cgt att cat      149
 Met His Leu His Ile His Gly Gly Val Cys Ile His Met Arg Ile His
          25                  30                  35

 gcg tgt gca tgg ctg tgt ccg tgt gtg tgt gca ctc acg tgc aca tgt      197
 Ala Cys Ala Trp Leu Cys Pro Cys Val Cys Ala Leu Thr Cys Thr Cys
      40                  45                  50

 ggg tgt atg tgt gcg tgt gta ttc ctg tgt gta ttc gtg ggg tgg gtg      245
 Gly Cys Met Cys Ala Cys Val Phe Leu Cys Val Phe Val Gly Trp Val
  55                  60                  65                  70

 ttg cgt gtt cat gtt gtc tgg taa gggctgtgtg acctcaggga tggctgcaga     299
 Leu Arg Val His Val Val Trp 
                  75

 acactccggc ctgagtgaaa ggtggtctga tctgcagaca gagcttctct ggaaggaaga    359

 agggcggccc ctggggagag gtgggtgggc tgggtgggga agggggatgg ggggctcctg    419

 tgccttccct ccttgcctc                                                 438




      <210> 491
      <211> 717
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (21)..(332)

      <400> 491
 aaaaagttca aagccaaaca    atg ttt aac ctc tcc ttt ttt aca ttg tat      50
                          Met Phe Asn Leu Ser Phe Phe Thr Leu Tyr
                            1               5                  10

 gga ctt tgt atg ctg aag ctt cat tca gcc tcc tcc tgg ttc aca ttg       98
 Gly Leu Cys Met Leu Lys Leu His Ser Ala Ser Ser Trp Phe Thr Leu
                  15                  20                  25

 tta ttg tta ata tca tta ttt ttg tct gtc gtt tat tgt cag tct aca      146
 Leu Leu Leu Ile Ser Leu Phe Leu Ser Val Val Tyr Cys Gln Ser Thr
              30                  35                  40

 aat tac ata tta tta ttg ttt ttg ttt tat aca ggc aac att tat ctg      194
 Asn Tyr Ile Leu Leu Leu Phe Leu Phe Tyr Thr Gly Asn Ile Tyr Leu
          45                  50                  55

 gat ttg cat aga tgt tta cca ttt tct tta ctc agt gtt tta tca aat      242
 Asp Leu His Arg Cys Leu Pro Phe Ser Leu Leu Ser Val Leu Ser Asn
      60                  65                  70

 aca tcc ttt agg aat tcc ttt aat ttg gtc tct tgt tgg cgt atg ttc      290
 Thr Ser Phe Arg Asn Ser Phe Asn Leu Val Ser Cys Trp Arg Met Phe
  75                  80                  85                  90

 agt ttt cat ttg tct att aaa tgt tta tca ctt ttt tcg tga taggttg      339
 Ser Phe His Leu Ser Ile Lys Cys Leu Ser Leu Phe Ser 
                  95                 100

 ttctgctggg ttcacaattt taggttgcca gttctgtttt tttgtttgtt tgtttgtttg    399

 acacttggaa gatattattc tagtgtcttc aatattctgt ctttggtctt tggtcattct    459

 aattaccttt tctttgtata tgatctgtcc cttctccatg gcttctttta aaatcttctc    519

 tttatctttg ggtgtttttc agttaaatat gtaatagaac taggcactga tttgtttata    579

 tttatcctgc tcgagacaca tgatgtttca agtatctgtg gccttttata gtttaaaata    639

 atttcgggaa aagtcaaagc attatctctt taaccgctcc ctctcttcca ttccctttgt    699

 tctctcttcc tcgaactc                                                  717




      <210> 492
      <211> 704
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (207)..(434)

      <400> 492
 gaaattcttc actaaggggt ttcaaaccac agtgcaactt cagaccacaa tcctgtacaa     60

 gagccagctt gtgatttaca aattctccag ggaaagtgac aggttggaga taggcatggg    120

 gttttgttgt tgttcttgtt gactcctgca ttctgcatgg caggacctag gcctctttac    180

 ctgtacattg caggtataac cctttc atg aca cag gtt cat cag agg gtt tta     233
                              Met Thr Gln Val His Gln Arg Val Leu
                                1               5

 gtc tgc act gtg gca gac ctt ggc ttt atc tct tgc ctt gac ctc cta      281
 Val Cys Thr Val Ala Asp Leu Gly Phe Ile Ser Cys Leu Asp Leu Leu
  10                  15                  20                  25

 cat tat caa caa agt gag agt tta aga tct cct ggg cag gag att tca      329
 His Tyr Gln Gln Ser Glu Ser Leu Arg Ser Pro Gly Gln Glu Ile Ser
                  30                  35                  40

 gaa gcc agc cta agt ttt ggg cct tcc tca cct cct agg gcc ttt gtg      377
 Glu Ala Ser Leu Ser Phe Gly Pro Ser Ser Pro Pro Arg Ala Phe Val
              45                  50                  55

 tca ggt tct ttt ggg ttc ttc ata ttc ctt acc tcc ctt tca gtg atg      425
 Ser Gly Ser Phe Gly Phe Phe Ile Phe Leu Thr Ser Leu Ser Val Met
          60                  65                  70

 tta tta taa agatttt gatttattca gcatttcacg gtctgtttag tgaggtgctt      481
 Leu Leu 
      75

 aacattgaac ttctgaaatg aagggcatat agcttaggga aggcatacct ttggttggcc    541

 ctgaaaagta atggtttaca tctggtttcc caaaaaatta atagctcccc ttttccacac    601

 gcacaaaaat tggttcattg gatgataaac ttgtgtgcct cctacacata gccttgggaa    661

 ttcattttgg aacacagcat gggtggagat caccaaggtg gtt                      704




      <210> 493
      <211> 850
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (35)..(850)

      <400> 493
 tttcgtcgga ctctgggagg gctaaggagc catc    atg atc cct aag ctg ctt      52
                                          Met Ile Pro Lys Leu Leu
                                            1               5

 tcc ctc ctc tgt ttc aga ctg tgc gtg ggc caa gga gac aca agg gga      100
 Ser Leu Leu Cys Phe Arg Leu Cys Val Gly Gln Gly Asp Thr Arg Gly
              10                  15                  20

 gat ggg tca ctg ccc aag ccg tcc ctc agt gcc tgg ccc agc tcg gtg      148
 Asp Gly Ser Leu Pro Lys Pro Ser Leu Ser Ala Trp Pro Ser Ser Val
          25                  30                  35

 gtt cct gcc aac agc aat gtg acg ctg cga tgt tgg act cct gcc aga      196
 Val Pro Ala Asn Ser Asn Val Thr Leu Arg Cys Trp Thr Pro Ala Arg
      40                  45                  50

 ggt gtg agc ttt gtt ctc agg aag gga gga att att ctg gag tcc ccg      244
 Gly Val Ser Phe Val Leu Arg Lys Gly Gly Ile Ile Leu Glu Ser Pro
  55                  60                  65                  70

 aag ccc ctt gat tct aca gag ggc gcg gcc gaa ttt cac ctc aat aat      292
 Lys Pro Leu Asp Ser Thr Glu Gly Ala Ala Glu Phe His Leu Asn Asn
                  75                  80                  85

 cta aaa gtc aga aat gct gga gag tac acc tgt gaa tac tac aga aaa      340
 Leu Lys Val Arg Asn Ala Gly Glu Tyr Thr Cys Glu Tyr Tyr Arg Lys
              90                  95                 100

 gca tcc ccc cac atc ctt tca cag cgc agt gac gtc ctt cta ctg ttg      388
 Ala Ser Pro His Ile Leu Ser Gln Arg Ser Asp Val Leu Leu Leu Leu
         105                 110                 115

 gtg aca gga cat tta tct aaa cct ttc ctc cga acc tac caa agg ggt      436
 Val Thr Gly His Leu Ser Lys Pro Phe Leu Arg Thr Tyr Gln Arg Gly
     120                 125                 130

 aca gtg acc gca ggt gga agg gtg act ctg cag tgc cag aag cga gac      484
 Thr Val Thr Ala Gly Gly Arg Val Thr Leu Gln Cys Gln Lys Arg Asp
 135                 140                 145                 150

 caa ttg ttt gtg cct atc atg ttc gct cta ctg aag gca ggg acg cca      532
 Gln Leu Phe Val Pro Ile Met Phe Ala Leu Leu Lys Ala Gly Thr Pro
                 155                 160                 165

 tca ccc atc cag ctg cag agt cca gcg ggg aag gag ata gac ttc tct      580
 Ser Pro Ile Gln Leu Gln Ser Pro Ala Gly Lys Glu Ile Asp Phe Ser
             170                 175                 180

 ctg gtg gac gtg aca gcc ggc gat gct ggg aac tac agc tgc atg tac      628
 Leu Val Asp Val Thr Ala Gly Asp Ala Gly Asn Tyr Ser Cys Met Tyr
         185                 190                 195

 tac cag aca aag tct ccc ttc tgg gcc tca gaa ccc agt gat cag ctt      676
 Tyr Gln Thr Lys Ser Pro Phe Trp Ala Ser Glu Pro Ser Asp Gln Leu
     200                 205                 210

 gag ata ttg gtg aca gtt ccc cca ggt acc aca tcg agc aac tac tcc      724
 Glu Ile Leu Val Thr Val Pro Pro Gly Thr Thr Ser Ser Asn Tyr Ser
 215                 220                 225                 230

 ctg ggt aac ttc gta cga ctg ggt ctg gct gcc gta att gtg gtt atc      772
 Leu Gly Asn Phe Val Arg Leu Gly Leu Ala Ala Val Ile Val Val Ile
                 235                 240                 245

 atg gga gct ttc ctg gtg gag gcc tgg tac agc cgg aat gtg tct cca      820
 Met Gly Ala Phe Leu Val Glu Ala Trp Tyr Ser Arg Asn Val Ser Pro
             250                 255                 260

 ggt gaa tca gag gcc ttc aaa cca gag tga                              850
 Gly Glu Ser Glu Ala Phe Lys Pro Glu 
         265                 270





      <210> 494
      <211> 817
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (489)..(815)

      <400> 494
 gcacgagatc gtgtccagcc tgaaatcagc tttaattgtc ccccaggtaa ataaacacct     60

 ggtgaaagtc acctttggaa aattaatgct tttgaaaata atccatgagt ctaagtatga    120

 ctttcaaatc accttcaccg tgtgtctggg aacatttcag gttgatttcc tacatcacat    180

 cactcctctt ctgcttattg tattcccact tactagacgt caggtgttgg tttattagga    240

 gacattgctg tgcatgtcac acagccagtt ggcaccacat ttttggctcc ttctgttgaa    300

 tctctttcta gttggctggc aagttaaatc tgttcattga gaagggagcg tgtgcatatt    360

 tgtgcttgtt tatgtatgta ttactggcag gggatgagac agaagcaaaa gttgggtcag    420

 ttaaatacaa tcgtctctct tctactttgt agtttttgga gatatttttc catgccattt    480

 tgtaacag atg ata tcc tgg gtt tta tta ttc agt ctt ttg tgt ccg tca     530
          Met Ile Ser Trp Val Leu Leu Phe Ser Leu Leu Cys Pro Ser
            1               5                  10

 gtg aat tat ttg tta gcc ttt gag cct aca tat gta gca ttt tat tat      578
 Val Asn Tyr Leu Leu Ala Phe Glu Pro Thr Tyr Val Ala Phe Tyr Tyr
  15                  20                  25                  30

 ggg aat aat aat ata gaa gca atg tat gta ttt aca tat cca tgt ctc      626
 Gly Asn Asn Asn Ile Glu Ala Met Tyr Val Phe Thr Tyr Pro Cys Leu
                  35                  40                  45

 aga ttg tta gag act ggt gac cag agt aat gat atc cat gag tta gct      674
 Arg Leu Leu Glu Thr Gly Asp Gln Ser Asn Asp Ile His Glu Leu Ala
              50                  55                  60

 tac atg aga att tct ggg gac agt agt ggg ttc tta ctg tgt gcc agg      722
 Tyr Met Arg Ile Ser Gly Asp Ser Ser Gly Phe Leu Leu Cys Ala Arg
          65                  70                  75

 caa tgt ttt agg tac ttt atg cat atc aac tta ttt aat tct cat agc      770
 Gln Cys Phe Arg Tyr Phe Met His Ile Asn Leu Phe Asn Ser His Ser
      80                  85                  90

 aac act acg acg cac gtg cta cta tta tct gca tgt tcc agg tga cg       817
 Asn Thr Thr Thr His Val Leu Leu Leu Ser Ala Cys Ser Arg 
  95                 100                 105





      <210> 495
      <211> 881
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (55)..(831)

      <400> 495
 cggcacgagg ggaacagaac agaacattga gggagggcct cagaactgga aacc  atg      57
                                                              Met
                                                                1

 gct acc gtg ttg atg aga act ccc agc tgc ctg gac caa gaa gcc ggt      105
 Ala Thr Val Leu Met Arg Thr Pro Ser Cys Leu Asp Gln Glu Ala Gly
               5                  10                  15

 gct gaa gaa cta ggc agg acg tcc gag agg agc tgt gtc cat gtc ggc      153
 Ala Glu Glu Leu Gly Arg Thr Ser Glu Arg Ser Cys Val His Val Gly
          20                  25                  30

 ccc gct ggc cag ttt cct ggg tgc gct gcc acc atg gtc tgg ttc tgc      201
 Pro Ala Gly Gln Phe Pro Gly Cys Ala Ala Thr Met Val Trp Phe Cys
      35                  40                  45

 aac agt gcc gac tgc caa ttt tca gtc ttc gcc ctt acc acc ata gga      249
 Asn Ser Ala Asp Cys Gln Phe Ser Val Phe Ala Leu Thr Thr Ile Gly
  50                  55                  60                  65

 tgg atc ctc tcc tct acg tcc acg ggc ctc gtg gag tgg cga ata tgg      297
 Trp Ile Leu Ser Ser Thr Ser Thr Gly Leu Val Glu Trp Arg Ile Trp
                  70                  75                  80

 tac atg aaa gac acc tcg ctc tac ccc cct gga atc gcc tgc gtg gga      345
 Tyr Met Lys Asp Thr Ser Leu Tyr Pro Pro Gly Ile Ala Cys Val Gly
              85                  90                  95

 ata ttt aga gtc tgc att tac cgg cgt cgc acc aac agc acc aca acc      393
 Ile Phe Arg Val Cys Ile Tyr Arg Arg Arg Thr Asn Ser Thr Thr Thr
         100                 105                 110

 aaa ttt tgt tac cga tac agc tac cag gac acc ttt ctc cct ttt gaa      441
 Lys Phe Cys Tyr Arg Tyr Ser Tyr Gln Asp Thr Phe Leu Pro Phe Glu
     115                 120                 125

 att tcc atg gct caa cgc ttc cta ctg act gcc agc att ttc gga ttc      489
 Ile Ser Met Ala Gln Arg Phe Leu Leu Thr Ala Ser Ile Phe Gly Phe
 130                 135                 140                 145

 ttc ggg aga gcc ttt aac atg ttt gca ctt aga aac atg tcc atg aga      537
 Phe Gly Arg Ala Phe Asn Met Phe Ala Leu Arg Asn Met Ser Met Arg
                 150                 155                 160

 atg ttt gag gag gac acc tac aat tca ttc gtt gtt tca gga att ctc      585
 Met Phe Glu Glu Asp Thr Tyr Asn Ser Phe Val Val Ser Gly Ile Leu
             165                 170                 175

 aac att gct gct ggt gtc ttt aac tta att gct gtg ctc cag aac tac      633
 Asn Ile Ala Ala Gly Val Phe Asn Leu Ile Ala Val Leu Gln Asn Tyr
         180                 185                 190

 gat gcc gtc ata aac tca cag ggg atc acc ttc ctg cca tct ctc caa      681
 Asp Ala Val Ile Asn Ser Gln Gly Ile Thr Phe Leu Pro Ser Leu Gln
     195                 200                 205

 atg ccc ttc aag cca gat gtg cag gaa gtt ggc act gcc att caa gtg      729
 Met Pro Phe Lys Pro Asp Val Gln Glu Val Gly Thr Ala Ile Gln Val
 210                 215                 220                 225

 gca ggg ata ggt gtc ttg ccg atg ctg tta act ggg atg ttt tct ctg      777
 Ala Gly Ile Gly Val Leu Pro Met Leu Leu Thr Gly Met Phe Ser Leu
                 230                 235                 240

 ttt tac aaa tgt ccc ccg tac ggc caa gtg cat cct ggt att tca gaa      825
 Phe Tyr Lys Cys Pro Pro Tyr Gly Gln Val His Pro Gly Ile Ser Glu
             245                 250                 255

 atg tga atttcctggt tgcattggct ttgcaaatct aagatttctg ggagtttatg       881
 Met 






      <210> 496
      <211> 1601
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (30)..(632)

      <400> 496
 cgcccagccg gtccaggcct ctggcgaac  atg gcg ctt gtc ccc tgc cag gtg      53
                                  Met Ala Leu Val Pro Cys Gln Val
                                    1               5

 ctg cgg atg gca atc ctg ctg tcc tac tgc tct atc ctg tgt aac tac      101
 Leu Arg Met Ala Ile Leu Leu Ser Tyr Cys Ser Ile Leu Cys Asn Tyr
      10                  15                  20

 aag gcc atc gaa atg ccc tca cac cag acc tac gga ggg agc tgg aaa      149
 Lys Ala Ile Glu Met Pro Ser His Gln Thr Tyr Gly Gly Ser Trp Lys
  25                  30                  35                  40

 ttc ctg acg ttc att gat ctg gtt atc cag gct gtc ttt ttt ggc atc      197
 Phe Leu Thr Phe Ile Asp Leu Val Ile Gln Ala Val Phe Phe Gly Ile
                  45                  50                  55

 tgt gtg ctg act gat ctt tcc agt ctt ctg act cga gga agt ggg aac      245
 Cys Val Leu Thr Asp Leu Ser Ser Leu Leu Thr Arg Gly Ser Gly Asn
              60                  65                  70

 cag gag caa gag agg cag ctc aag aag ctc atc tct ctc cgg gac tgg      293
 Gln Glu Gln Glu Arg Gln Leu Lys Lys Leu Ile Ser Leu Arg Asp Trp
          75                  80                  85

 atg tta gct gtg ttg gcc ttt cct gtt ggg gtt ttt gtt gta gca gtg      341
 Met Leu Ala Val Leu Ala Phe Pro Val Gly Val Phe Val Val Ala Val
      90                  95                 100

 ttc tgg atc att tat gcc tat gac aga gag atg ata tac ccg aag ctg      389
 Phe Trp Ile Ile Tyr Ala Tyr Asp Arg Glu Met Ile Tyr Pro Lys Leu
 105                 110                 115                 120

 ctg gat aat ttt atc cca ggg tgg ctg aat cac gga atg tgg gtg tgc      437
 Leu Asp Asn Phe Ile Pro Gly Trp Leu Asn His Gly Met Trp Val Cys
                 125                 130                 135

 tgg gtg cat cat gta act ggc atg tgg gtg tac cct ttc ctg gaa cac      485
 Trp Val His His Val Thr Gly Met Trp Val Tyr Pro Phe Leu Glu His
             140                 145                 150

 att ggc cca gga gcc aga atc atc ttc ttt ggg tct aca acc atc tta      533
 Ile Gly Pro Gly Ala Arg Ile Ile Phe Phe Gly Ser Thr Thr Ile Leu
         155                 160                 165

 atg aac ttc ctg tac ctg ctg gga gaa gtt ctg aac aac tat atc tgg      581
 Met Asn Phe Leu Tyr Leu Leu Gly Glu Val Leu Asn Asn Tyr Ile Trp
     170                 175                 180

 gat aca cag aaa agt atg gaa gaa gag aaa gaa aag cct aaa ttg gaa      629
 Asp Thr Gln Lys Ser Met Glu Glu Glu Lys Glu Lys Pro Lys Leu Glu
 185                 190                 195                 200

 tga gatc caagtctaaa cgcaagagct agattgagcc gccattgaag actcccttcc      686
 


 ccctcggggc attgggcagt gggggagaaa aggcttcaaa ggaacttggt ggcatcagca    746

 cccccctccc ccaatgagga caccttttat atataaatat gtataaacat agaatacagt    806

 tgtttccaaa agaactcacc ctcactgtgt gttaaagaat tcttcccaaa gtcattactg    866

 ataataacat tttttccttt tctagtttta aaaccagaat tggaccttgg atttttattt    926

 tggcaattgt aactccatct aatcaagaaa gaataaaagt ttattgcact tctttttgag    986

 aactatgtta aagtcaaagg ggcatatata gagtaaggct tttgtgtatt taatcctaaa   1046

 ggtggctgta atcatgaacc taggccacca tggggacctg agagggaagg ggacagatgt   1106

 ttctcattgc ataatgtcac agttgcctca aatgagcacc atttgtaata atgatgtcaa   1166

 tttcatgaaa agcctgagtg tattgcatct cttgatttaa tcatgtgaaa cttttcctag   1226

 atgcaaatgc tgactaataa agacaaagcc accctgaacc tgacgtctgc attgtgcatc   1286

 tcaaaatcct aacagcatta gtatctcctt ttcattttta ttacctgttg aaaatgggtt   1346

 tactgaacct ggttctttcc tataattttt ggattttaaa aaatgtgaat ctttttgata   1406

 actccaaaac aaattttttt tttctttttt tccagatgga gtctcactct gtcgcccagg   1466

 ctggagtaca ggggcgtgat ctcacctcac cacaagctcc gctttccggg ttcatgccat   1526

 tctcctgcct tcttcaccct cccgagtagt tggaattatc agcccctgcg caccgcccgg   1586

 gttaattttc tgact                                                    1601




      <210> 497
      <211> 2503
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (60)..(1436)

      <400> 497
 tcgggaggtt aatcggccga ggggagttgg ctcgcgctgg tgacggcgcc tgggtcccc      59                                                                 
 atg gcg ctg tgg cgc ggc tcc gcg tac gcg ggc ttc ctg gcg ctg gcc      107
 Met Ala Leu Trp Arg Gly Ser Ala Tyr Ala Gly Phe Leu Ala Leu Ala
   1               5                  10                  15

 gtg ggc tgc gtc ttc ctg ctg gag cca gag ctg cca ggc tcg gcg ctg      155
 Val Gly Cys Val Phe Leu Leu Glu Pro Glu Leu Pro Gly Ser Ala Leu
              20                  25                  30

 cgc tct ctc tgg agc tcg ctg tgt ctg ggg ccc gcg cct gcg ccc ccg      203
 Arg Ser Leu Trp Ser Ser Leu Cys Leu Gly Pro Ala Pro Ala Pro Pro
          35                  40                  45

 gga ccc gtc tcc ccc gag ggc cgg ttg gcg gca gcc tgg gac gcg ctt      251
 Gly Pro Val Ser Pro Glu Gly Arg Leu Ala Ala Ala Trp Asp Ala Leu
      50                  55                  60

 atc gtg cgg cca gtc cgg cgc tgg cgc cgc gtg gca gtg gga gtc aat      299
 Ile Val Arg Pro Val Arg Arg Trp Arg Arg Val Ala Val Gly Val Asn
  65                  70                  75                  80

 gca tgt gtt gat gtg gtg ctc tca ggg gtg aag ctc ttg cag gca ctt      347
 Ala Cys Val Asp Val Val Leu Ser Gly Val Lys Leu Leu Gln Ala Leu
                  85                  90                  95

 ggc ctt agt cct ggg aat ggg aaa gat cac agc att ctg cat tca agg      395
 Gly Leu Ser Pro Gly Asn Gly Lys Asp His Ser Ile Leu His Ser Arg
             100                 105                 110

 aat gat ctg gaa gaa gcc ttc att cac ttc atg ggg aag gga gca gct      443
 Asn Asp Leu Glu Glu Ala Phe Ile His Phe Met Gly Lys Gly Ala Ala
         115                 120                 125

 gct gag cgc ttc ttc agt gat aag gaa act ttt cac gac att gcc cag      491
 Ala Glu Arg Phe Phe Ser Asp Lys Glu Thr Phe His Asp Ile Ala Gln
     130                 135                 140

 gtt gcg tca gag ttc cca gga gcc cag cac tat gta gga gga aat gca      539
 Val Ala Ser Glu Phe Pro Gly Ala Gln His Tyr Val Gly Gly Asn Ala
 145                 150                 155                 160

 gct tta att gga cag aaa ttt gca gcc aac tca gat tta aag gtt ctt      587
 Ala Leu Ile Gly Gln Lys Phe Ala Ala Asn Ser Asp Leu Lys Val Leu
                 165                 170                 175

 ctt tgc ggt cca gtt ggt cca aag cta cat gag ctt ctt gat gac aat      635
 Leu Cys Gly Pro Val Gly Pro Lys Leu His Glu Leu Leu Asp Asp Asn
             180                 185                 190

 gtc ttt gtt cca cca gag tca ttg cag gaa gtg gat gag ttc cac ctc      683
 Val Phe Val Pro Pro Glu Ser Leu Gln Glu Val Asp Glu Phe His Leu
         195                 200                 205

 att tta gag tat caa gca ggg gag gag tgg ggc cag tta aaa gct ccc      731
 Ile Leu Glu Tyr Gln Ala Gly Glu Glu Trp Gly Gln Leu Lys Ala Pro
     210                 215                 220

 cat gcc aac cga ttc atc ttc tct cac gac ctc tcc aac ggg gcc atg      779
 His Ala Asn Arg Phe Ile Phe Ser His Asp Leu Ser Asn Gly Ala Met
 225                 230                 235                 240

 aat atg ctg gag gtg ttt gtg tct agc ctg gag gag ttt cag cca gac      827
 Asn Met Leu Glu Val Phe Val Ser Ser Leu Glu Glu Phe Gln Pro Asp
                 245                 250                 255

 ctg gtg gtc ctc tct gga ttg cac atg atg gag gga caa agc aag gag      875
 Leu Val Val Leu Ser Gly Leu His Met Met Glu Gly Gln Ser Lys Glu
             260                 265                 270

 ctc cag agg aag aga ctc ttg gag gtt gta acc tcc att tct gac atc      923
 Leu Gln Arg Lys Arg Leu Leu Glu Val Val Thr Ser Ile Ser Asp Ile
         275                 280                 285

 ccc act ggt att cca gtt cac cta gag ctg gcc agt atg act aac agg      971
 Pro Thr Gly Ile Pro Val His Leu Glu Leu Ala Ser Met Thr Asn Arg
     290                 295                 300

 gag ctc atg agc agc att gtc cat cag cag gtc ttt ccc gcg gtg act     1019
 Glu Leu Met Ser Ser Ile Val His Gln Gln Val Phe Pro Ala Val Thr
 305                 310                 315                 320

 tcc ctt ggg ctg aat gaa cag gag ctg tta ttt ctc acc cag tca gcc     1067
 Ser Leu Gly Leu Asn Glu Gln Glu Leu Leu Phe Leu Thr Gln Ser Ala
                 325                 330                 335

 tct gga cct cac tct tct ctc tct tcc tgg aac ggt gtt cct gat gtg     1115
 Ser Gly Pro His Ser Ser Leu Ser Ser Trp Asn Gly Val Pro Asp Val
             340                 345                 350

 ggc atg gtc agt gac atc ctc ttc tgg atc ttg aaa gaa cat ggg agg     1163
 Gly Met Val Ser Asp Ile Leu Phe Trp Ile Leu Lys Glu His Gly Arg
         355                 360                 365

 agt aaa agc aga gcc tcg gat ctc acc agg atc cat ttc cac acg ctg     1211
 Ser Lys Ser Arg Ala Ser Asp Leu Thr Arg Ile His Phe His Thr Leu
     370                 375                 380

 gtc tac cac atc ctg gca act gtg gat gga cac tgg gcc aac cag ctg     1259
 Val Tyr His Ile Leu Ala Thr Val Asp Gly His Trp Ala Asn Gln Leu
 385                 390                 395                 400

 gca gcc gtg gct gca gga gct cgt gtg gct ggg aca cag gcc tgc gcc     1307
 Ala Ala Val Ala Ala Gly Ala Arg Val Ala Gly Thr Gln Ala Cys Ala
                 405                 410                 415

 aca gaa acc ata gac acc agc cga gtg tct ctg agg gca ccc cag gat     1355
 Thr Glu Thr Ile Asp Thr Ser Arg Val Ser Leu Arg Ala Pro Gln Asp
             420                 425                 430

 tgt att aaa ccc aaa caa gcc agt agt aga atg gca cag aga ggg aat     1403
 Cys Ile Lys Pro Lys Gln Ala Ser Ser Arg Met Ala Gln Arg Gly Asn
         435                 440                 445

 atc ctt cca ctt cac acc agt att ggt gtg taa agacccca ttcgaactgt     1454
 Ile Leu Pro Leu His Thr Ser Ile Gly Val 
     450                 455

 aggccttgga gatgccattt cagccgaagg actcttctat tcggaagtac accctcacta   1514

 ttaggaagat tcttaggggt aatttttctg aggaaggaga actagccaac ttaagaatta   1574

 caggaagaaa gtggtttgga agacagccaa agaaataaaa gcagattaaa ctgtatcagg   1634

 tacattccag cctgttggca actccataaa aacatttcag attttaatcc gaatttagct   1694

 aatgagactg gatttttgtt ttttatgttg tgtgtcacag agctaaaaac tcagttccca   1754

 aatccccagt ttatgcagcg ccatcaggta ttttaagcta aacttcttca cccctgagag   1814

 catgtcagct ggagaaaagc agttcttcct tgcccacttg agaagtgcac gcccactcac   1874

 ccaacatcct ggtctctagg aaagcctcat gtgaggttcc tctttctttc agctcagtgc   1934

 ccatgggcaa ggatcatgat ttccattccg tgttacaatg acaatattta atgagcataa   1994

 ccttctcagt ctcctgctct caaatttagg acagagccgc taaggacaaa acaatccctc   2054

 ccgtgcttta tgatggcagc aggggctggg gagcctctga gggactcttt cattctgcag   2114

 ttgtctggaa gcctgggtgg cgtcatgagc tgaaggatca tgctttcctg tcctggctcc   2174

 ataggttata ggctggctgg tgaaaggttc acgtggccca ggctgaactt cattgcctag   2234

 ctttggatgt gctttctgcc ataaagactg atttttgttc gttctgagcc ttcaaggaat   2294

 ttgtttttta caactggaat atgctcctgt gtgtgttaac agatcatgga tgttttatgt   2354

 tttcactgat catttaaaga gtttgacctc agagctccag gatcatcagt aaatttgtca   2414

 tgttatatat ttattttttt ataaatcaag acttctgtgt gctcttaaat atattaaaaa   2474

 caatttacat ttcaggaaaa aaaaaaaaa                                     2503




      <210> 498
      <211> 2979
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (1)..(2160)

      <400> 498
  atg aag aca gcg ccg gct ggg atg ccg atg acc acg ggc cac ggc agg      48
  Met Lys Thr Ala Pro Ala Gly Met Pro Met Thr Thr Gly His Gly Arg
    1               5                  10                  15

 cta gtg gcc gag gac gag gag gcc aca ggt ggc cct ggc ggt ttt ggg       96
 Leu Val Ala Glu Asp Glu Glu Ala Thr Gly Gly Pro Gly Gly Phe Gly
              20                  25                  30

 tct gca aga gcg aga gga aag gag cac gag ctg ccc cat gac ctt cct      144
 Ser Ala Arg Ala Arg Gly Lys Glu His Glu Leu Pro His Asp Leu Pro
          35                  40                  45

 gtg gtg gcc aag ggc atg gga cct ggt ctt gcc cac gtg aag ggt gac      192
 Val Val Ala Lys Gly Met Gly Pro Gly Leu Ala His Val Lys Gly Asp
      50                  55                  60

 agt gga aga gcc agg aag ccc cag gtg cag ccc ctc cct ggg gag acg      240
 Ser Gly Arg Ala Arg Lys Pro Gln Val Gln Pro Leu Pro Gly Glu Thr
  65                  70                  75                  80

 gct gcc act ctg ggc tcc tcc ctt ctc cct ggg ccc cct cgg tcg ccc      288
 Ala Ala Thr Leu Gly Ser Ser Leu Leu Pro Gly Pro Pro Arg Ser Pro
                  85                  90                  95

 tgc ccc tca gat tcc atg ccc cag ccc cac ccc tgc aag gca ttg ccc      336
 Cys Pro Ser Asp Ser Met Pro Gln Pro His Pro Cys Lys Ala Leu Pro
             100                 105                 110

 aga agc ccg ctg gcc ccc aag gag cct ccc gac gcg tgc ccc cca aag      384
 Arg Ser Pro Leu Ala Pro Lys Glu Pro Pro Asp Ala Cys Pro Pro Lys
         115                 120                 125

 atg gcg gac aag gtg gtc cca cgg cag gtg gcc cgg ctg ggc cgc act      432
 Met Ala Asp Lys Val Val Pro Arg Gln Val Ala Arg Leu Gly Arg Thr
     130                 135                 140

 atg cgg ctg cag tgc cca gtg gag ggg gac ccg ccg ccg ctg acc atg      480
 Met Arg Leu Gln Cys Pro Val Glu Gly Asp Pro Pro Pro Leu Thr Met
 145                 150                 155                 160

 tgg acc aag gat ggc cgc acc atc cac agc ggc tgg agc cgc ttc cgc      528
 Trp Thr Lys Asp Gly Arg Thr Ile His Ser Gly Trp Ser Arg Phe Arg
                 165                 170                 175

 gtg ctg ccg cag ggg ctg aag gtg aag cag gtg gag cgg gag gat gcc      576
 Val Leu Pro Gln Gly Leu Lys Val Lys Gln Val Glu Arg Glu Asp Ala
             180                 185                 190

 ggc gtg tac gtg tgc aag acc acc aac ggc ttc ggc agc ctg agc gtc      624
 Gly Val Tyr Val Cys Lys Thr Thr Asn Gly Phe Gly Ser Leu Ser Val
         195                 200                 205

 aac tac acc ctc gtc gtg ctg gat gac att agc cca ggg aag gag agc      672
 Asn Tyr Thr Leu Val Val Leu Asp Asp Ile Ser Pro Gly Lys Glu Ser
     210                 215                 220

 ctg ggg ccc gac agc tcc tct ggg ggt caa gag gac ccc gcc agc cag      720
 Leu Gly Pro Asp Ser Ser Ser Gly Gly Gln Glu Asp Pro Ala Ser Gln
 225                 230                 235                 240

 cag tgg gca cga ccg cgc ttc aca cag ccc tcc aag atg agg cgc cgg      768
 Gln Trp Ala Arg Pro Arg Phe Thr Gln Pro Ser Lys Met Arg Arg Arg
                 245                 250                 255

 gtg atc gca cgg ccc gtg ggt agc tcc gtg cgg ctc aag tgc gtg gcc      816
 Val Ile Ala Arg Pro Val Gly Ser Ser Val Arg Leu Lys Cys Val Ala
             260                 265                 270

 agc ggg cac cct cgg ccc gac atc acg tgg atg aag gac gac cag gcc      864
 Ser Gly His Pro Arg Pro Asp Ile Thr Trp Met Lys Asp Asp Gln Ala
         275                 280                 285

 ttg acg cgc cca gag gcc gct gag ccc agg aag aag aag tgg aca ctg      912
 Leu Thr Arg Pro Glu Ala Ala Glu Pro Arg Lys Lys Lys Trp Thr Leu
     290                 295                 300

 agc ctg aag aac ctg cgg ccg gag gac agc ggc aaa tac acc tgc cgc      960
 Ser Leu Lys Asn Leu Arg Pro Glu Asp Ser Gly Lys Tyr Thr Cys Arg
 305                 310                 315                 320

 gtg tcg aac cgc gcg ggc gcc atc aac gcc acc tac aag gtg gat gtg     1008
 Val Ser Asn Arg Ala Gly Ala Ile Asn Ala Thr Tyr Lys Val Asp Val
                 325                 330                 335

 atc cag cgg acc cgt tcc aag ccc gtg ctc aca ggc acg cac ccc gtg     1056
 Ile Gln Arg Thr Arg Ser Lys Pro Val Leu Thr Gly Thr His Pro Val
             340                 345                 350

 aac acg acg gtg gac ttc ggg ggg acc acg tcc ttc cag tgc aag gtg     1104
 Asn Thr Thr Val Asp Phe Gly Gly Thr Thr Ser Phe Gln Cys Lys Val
         355                 360                 365

 cgc agc gac gtg aag ccg gtg atc cag tgg ctg aag cgc gtg gag tac     1152
 Arg Ser Asp Val Lys Pro Val Ile Gln Trp Leu Lys Arg Val Glu Tyr
     370                 375                 380

 ggc gcc gag ggc cgc cac aac tcc acc atc gat gtg ggc ggc cag aag     1200
 Gly Ala Glu Gly Arg His Asn Ser Thr Ile Asp Val Gly Gly Gln Lys
 385                 390                 395                 400

 ttt gtg gtg ctg ccc acg ggt gac gtg tgg tcg cgg ccc gac ggc tcc     1248
 Phe Val Val Leu Pro Thr Gly Asp Val Trp Ser Arg Pro Asp Gly Ser
                 405                 410                 415

 tac ctc aat aag ctg ctc atc acc cgt gcc cgc cag gac gat gcg ggc     1296
 Tyr Leu Asn Lys Leu Leu Ile Thr Arg Ala Arg Gln Asp Asp Ala Gly
             420                 425                 430

 atg tac atc tgc ctt ggc gcc aac acc atg ggc tac agc ttc cgc agc     1344
 Met Tyr Ile Cys Leu Gly Ala Asn Thr Met Gly Tyr Ser Phe Arg Ser
         435                 440                 445

 gcc ttc ctc acc gtg ctg cca gac cca aaa ccg cca ggg cca cct gtg     1392
 Ala Phe Leu Thr Val Leu Pro Asp Pro Lys Pro Pro Gly Pro Pro Val
     450                 455                 460

 gcc tcc tcg tcc tcg gcc act agc ctg ccg tgg ccc gtg gtc atc ggc     1440
 Ala Ser Ser Ser Ser Ala Thr Ser Leu Pro Trp Pro Val Val Ile Gly
 465                 470                 475                 480

 atc cca gcc ggc gct gtc ttc atc ctg ggc acc ctg ctc ctg tgg ctt     1488
 Ile Pro Ala Gly Ala Val Phe Ile Leu Gly Thr Leu Leu Leu Trp Leu
                 485                 490                 495

 tgc cag gcc cag aag aag ccg tgc acc ccc gcg cct gcc cct ccc ctg     1536
 Cys Gln Ala Gln Lys Lys Pro Cys Thr Pro Ala Pro Ala Pro Pro Leu
             500                 505                 510

 cct ggg cac cgc ccg ccg ggg acg gcc cgc gac cgc agc gga gac aag     1584
 Pro Gly His Arg Pro Pro Gly Thr Ala Arg Asp Arg Ser Gly Asp Lys
         515                 520                 525

 gac ctt ccc tcg ttg gcc gcc ctc agc gct ggc cct ggt gtg ggg ctg     1632
 Asp Leu Pro Ser Leu Ala Ala Leu Ser Ala Gly Pro Gly Val Gly Leu
     530                 535                 540

 tgt gag gag cat ggg tct ccg gca gcc ccc cag cac tta ctg ggc cca     1680
 Cys Glu Glu His Gly Ser Pro Ala Ala Pro Gln His Leu Leu Gly Pro
 545                 550                 555                 560

 ggc cca gtt gct ggc cct aag ttg tac ccc aaa ctc tac aca gac atc     1728
 Gly Pro Val Ala Gly Pro Lys Leu Tyr Pro Lys Leu Tyr Thr Asp Ile
                 565                 570                 575

 cac aca cac aca cac tgt att gcg gcc gcc tgt gtg agg agc atg ggt     1776
 His Thr His Thr His Cys Ile Ala Ala Ala Cys Val Arg Ser Met Gly
             580                 585                 590

 ctc cgg cag ccc ccc agc act tac tgg gcc cag gcc cag ttg ctg gcc     1824
 Leu Arg Gln Pro Pro Ser Thr Tyr Trp Ala Gln Ala Gln Leu Leu Ala
         595                 600                 605

 cta agt tgt acc cca aac tct aca cag aca tcc aca cac aca cac aca     1872
 Leu Ser Cys Thr Pro Asn Ser Thr Gln Thr Ser Thr His Thr His Thr
     610                 615                 620

 cac act ctc aca cac act cac acg tgg agg gca agg tcc acc agc aca     1920
 His Thr Leu Thr His Thr His Thr Trp Arg Ala Arg Ser Thr Ser Thr
 625                 630                 635                 640

 tcc act atc agt gct aga cgg cac cgt atc tgc aga ggg cac ggg ggg     1968
 Ser Thr Ile Ser Ala Arg Arg His Arg Ile Cys Arg Gly His Gly Gly
                 645                 650                 655

 gcc ggc cag aca ggc aga ctg gga gga tgg agg acg gag ctg cag acg     2016
 Ala Gly Gln Thr Gly Arg Leu Gly Gly Trp Arg Thr Glu Leu Gln Thr
             660                 665                 670

 aag gca ggg gac cca tgg cga gga gga atg gcc agc acc cca ggc agt     2064
 Lys Ala Gly Asp Pro Trp Arg Gly Gly Met Ala Ser Thr Pro Gly Ser
         675                 680                 685

 ctg tgt gtg agg cat agc ccc tgg aca cac aca cac aga cac aca cac     2112
 Leu Cys Val Arg His Ser Pro Trp Thr His Thr His Arg His Thr His
     690                 695                 700

 tac ctg gat gca tgt atg cac aca cat gcg cgc aca cgt gct ccc tga     2160
 Tyr Leu Asp Ala Cys Met His Thr His Ala Arg Thr Arg Ala Pro 
 705                 710                 715

 aggcacacgt acgcacacac gcacatgcac agatatgccg cctgggcaca cagataagct   2220

 gcccaaatgc acgcacacgc acagagacat gccagaacat acaaggacat gctgcctgaa   2280

 catacacacg cacacccatg cgcagatgtg ctgcctggac acacacacac acacggatat   2340

 gctgtctgga cgcacacacg tgcagatatg gtatccggac acacacgtgc acagatatgc   2400

 tgcctggaca cacagataat gctgccttga cacacacatg cacggatatt gcctggacac   2460

 acacacacac acgtgtgcac agatatgctg tctggacacg cacacacatg cagatatgct   2520

 gcctggacac acacttccag acacacgtgc acaggcgcag atatgctgcc tggacacacg   2580

 cggatatgct gtctagtcac acacacacgc agacatgctg tccggacaca cacacgcatg   2640

 cacagatatg ctgtccggac acacacacgc acgcagatat gctgcctgga cacacacaca   2700

 gataatgctg cctcaacact cacacacgtg cagatattgc ctggacacac acatgtgcac   2760

 agatatgctg tctggacatg cacacacgtg cagatatgct gtccggatac acacgcacgc   2820

 acacatgcag atatgctgcc tgggcacaca cttccggaca cacatgcaca cacaggtgca   2880

 gatatgctgc ctggacacac gcagactgac gtgcttttgg gagggtgtgc cgtgaagcct   2940

 gcagtacgtg tgccgtgagg ctcatagttg atgagggac                          2979




      <210> 499
      <211> 2865
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (244)..(1317)

      <400> 499
 cgaattcccg ggtttctgcc agtcggaagg gaactccctt agatcccgcc cagaacctgg     60

 aattccagag cacacagggc caggacacct ttgtacccct gctccccacc ggcacaggtc    120

 ccacccaccc ccttctcccc gccccatgcc cgggtggagc cagctgccag ggcgccaaga    180

 ctcccagccc tctctctgtg cacggcagag tagaggccaa gggagggctc tgtgccagcc    240

 ccg  atg agg acg ctg ctg acc atc ttg act gtg gga tcc ctg gct gct     288
      Met Arg Thr Leu Leu Thr Ile Leu Thr Val Gly Ser Leu Ala Ala
        1               5                  10                  15

 cac gcc cct gag gac ccc tcg gat ctg ctc cag cac gtg aaa ttc cag      336
 His Ala Pro Glu Asp Pro Ser Asp Leu Leu Gln His Val Lys Phe Gln
                  20                  25                  30

 tcc agc aac ttt gaa aac atc ctg acg tgg gac agc ggg ccg gag ggc      384
 Ser Ser Asn Phe Glu Asn Ile Leu Thr Trp Asp Ser Gly Pro Glu Gly
              35                  40                  45

 acc cca gac acg gtc tac agc atc gag tat aag acg tac gga gag agg      432
 Thr Pro Asp Thr Val Tyr Ser Ile Glu Tyr Lys Thr Tyr Gly Glu Arg
          50                  55                  60

 gac tgg gtg gca aag aag ggc tgt cag cgg atc acc cgg aag tcc tgc      480
 Asp Trp Val Ala Lys Lys Gly Cys Gln Arg Ile Thr Arg Lys Ser Cys
      65                  70                  75

 aac ctg acg gtg gag acg ggc aac ctc acg gag ctc tac tat gcc agg      528
 Asn Leu Thr Val Glu Thr Gly Asn Leu Thr Glu Leu Tyr Tyr Ala Arg
  80                  85                  90                  95

 gtc acc gct gtc agt gcg gga ggc cgg tca gcc acc aag atg act gac      576
 Val Thr Ala Val Ser Ala Gly Gly Arg Ser Ala Thr Lys Met Thr Asp
                 100                 105                 110

 agg ttc agc tct ctg cag cac act acc ctc aag cca cct gat gtg acc      624
 Arg Phe Ser Ser Leu Gln His Thr Thr Leu Lys Pro Pro Asp Val Thr
             115                 120                 125

 tgt atc tcc aaa gtg aga tcg att cag atg att gtt cat cct acc ccc      672
 Cys Ile Ser Lys Val Arg Ser Ile Gln Met Ile Val His Pro Thr Pro
         130                 135                 140

 acg ccc atc cgt gca ggc gat ggc cac cgg cta acc ctg gaa gac atc      720
 Thr Pro Ile Arg Ala Gly Asp Gly His Arg Leu Thr Leu Glu Asp Ile
     145                 150                 155

 ttc cat gac ctg ttc tac cac tta gag ctc cag gtc aac cgc acc tac      768
 Phe His Asp Leu Phe Tyr His Leu Glu Leu Gln Val Asn Arg Thr Tyr
 160                 165                 170                 175

 caa atg cac ctt gga ggg aag cag aga gaa tat gag ttc ttc ggc ctg      816
 Gln Met His Leu Gly Gly Lys Gln Arg Glu Tyr Glu Phe Phe Gly Leu
                 180                 185                 190

 acc cct gac aca gag ttc ctt ggc acc atc atg att tgc gtt ccc acc      864
 Thr Pro Asp Thr Glu Phe Leu Gly Thr Ile Met Ile Cys Val Pro Thr
             195                 200                 205

 tgg gcc aag gag agt gcc ccc tac atg tgc cga gtg aag aca ctg cca      912
 Trp Ala Lys Glu Ser Ala Pro Tyr Met Cys Arg Val Lys Thr Leu Pro
         210                 215                 220

 gac cgg aca tgg acc tac tcc ttc tcc gga gcc ttc ctg ttc tcc atg      960
 Asp Arg Thr Trp Thr Tyr Ser Phe Ser Gly Ala Phe Leu Phe Ser Met
     225                 230                 235

 ggc ttc ctc gtc gca gta ctc tgc tac ctg agc tac aga tat gtc acc     1008
 Gly Phe Leu Val Ala Val Leu Cys Tyr Leu Ser Tyr Arg Tyr Val Thr
 240                 245                 250                 255

 aag ccg cct gca cct ccc aac tcc ctg aac gtc cag cga gtc ctg act     1056
 Lys Pro Pro Ala Pro Pro Asn Ser Leu Asn Val Gln Arg Val Leu Thr
                 260                 265                 270

 ttc cag ccg ctg cgc ttc atc cag gag cac gtc ctg atc cct gtc ttt     1104
 Phe Gln Pro Leu Arg Phe Ile Gln Glu His Val Leu Ile Pro Val Phe
             275                 280                 285

 gac ctc agc ggc ccc agc agt ctg gcc cag cct gtc cag tac tcc cag     1152
 Asp Leu Ser Gly Pro Ser Ser Leu Ala Gln Pro Val Gln Tyr Ser Gln
         290                 295                 300

 atc agg gtg tct gga ccc agg gag ccc gca gga gct cca cag cgg cat     1200
 Ile Arg Val Ser Gly Pro Arg Glu Pro Ala Gly Ala Pro Gln Arg His
     305                 310                 315

 agc cct gtc cga gat cac cta ctt agg gca gcc aga cat ctc cat cct     1248
 Ser Pro Val Arg Asp His Leu Leu Arg Ala Ala Arg His Leu His Pro
 320                 325                 330                 335

 cca gcc ctc caa cgt gcc acc tcc cca gat cct ctc ccc act gtc cta     1296
 Pro Ala Leu Gln Arg Ala Thr Ser Pro Asp Pro Leu Pro Thr Val Leu
                 340                 345                 350

 tgc ccc aaa cgc tgc ccc tga gg tcgggccccc atcctatgca cctcaggtga     1349
 Cys Pro Lys Arg Cys Pro 
             355

 cccccgaagc tcaattccca ttctacgccc cacaggccat ctctaaggtc cagccttcct   1409

 cctatgcccc tcaagccact ccggacagct ggcctccctc ctatggggta tgcatggaag   1469

 gttctggcaa agactccccc actgggacac tttctagtcc taaacacctt aggcctaaag   1529

 gtcagcttca gaaagagcca ccagctggaa gctgcatgtt aggtggcctt tctctgcagg   1589

 aggtgacctc cttggctatg gaggaatccc aagaagcaaa atcattgcac cagcccctgg   1649

 ggatttgcac agacagaaca tctgacccaa atgtgctaca cagtggggag gaagggacac   1709

 cacagtacct aaagggccag ctccccctcc tctcctcagt ccagatcgag ggccacccca   1769

 tgtccctccc tttgcaacct ccttccggtc catgttcccc ctcggaccaa ggtccaagtc   1829

 cctggggcct gctggagtcc cttgtgtgtc ccaaggatga agccaagagc ccagcccctg   1889

 agacctcaga cctggagcag cccacagaac tggattctct tttcagaggc ctggccctga   1949

 ctgtgcagtg ggagtcctga ggggaatggg aaaggcttgg tgcttcctcc ctgtccctac   2009

 ccagtgtcac atccttggct gtcaatccca tgcctgccca tgccacacac tctgcgatct   2069

 ggcctcagac gggtgccctt gagagaagca gagggagtgg catgcagggc ccctgccatg   2129

 ggtgcgctcc tcaccggaac aaagcagcat gataaggact gcagcggggg agctctgggg   2189

 agcagcttgt gtagacaagc gcgtgctcgc tgagccctgc aaggcagaaa tgacagtgca   2249

 aggaggaaat gcagggaaac tcccgaggtc cagagcccca cctcctaaca ccatggattc   2309

 aaagtgctca gggaatttgc ctctccttgc cccattcctg gccagtttca caatctagct   2369

 cgacagagca tgaggcccct gcctcttctg tcattgttca aaggtgggaa gagagcctgg   2429

 aaaagaacca ggcctggaaa agaaccagaa ggaggctggg cagaaccaga acaacctgca   2489

 cttctgccaa ggccagggcc agcaggacgg caggactcta gggaggggtg tggcctgcag   2549

 ctcattccca gccagggcaa ctgcctgacg ttgcacgatt tcagcttcat tcctctgata   2609

 gaacaaagcg aaatgcaggt ccaccaggga gggagacaca caagcctttt ctgcaggcag   2669

 gagtttcaga ccctatcctg agaatggggt ttgaaaggaa ggtgagggct gtggcccctg   2729

 gacgggtaca ataacacact gtactgatgt cacaactttg caagctctgc cttgggttca   2789

 gcccatctgg gctcaaattc cagcctcacc actcacaagc tgtgtgactt caaacaaatg   2849

 aaatcagtgc ccagaa                                                   2865




      <210> 500
      <211> 633
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (1)..(633)

      <400> 500
  atg tat ctg gta cac agt agt tgc tta ata tgt tgg cta aac aaa gag      48
  Met Tyr Leu Val His Ser Ser Cys Leu Ile Cys Trp Leu Asn Lys Glu
    1               5                  10                  15

 tgg aga ttc agt aaa ggt tcc atc gag cct ctg tac ctt acc tat gga       96
 Trp Arg Phe Ser Lys Gly Ser Ile Glu Pro Leu Tyr Leu Thr Tyr Gly
              20                  25                  30

 atc ata ttt gcc tgc ggc tgc tcc ttt gca tac cag cct tca ttg gtc      144
 Ile Ile Phe Ala Cys Gly Cys Ser Phe Ala Tyr Gln Pro Ser Leu Val
          35                  40                  45

 att ttg gga cac tat ttc aag aag cgc ctt gga ctg gtg aat ggc att      192
 Ile Leu Gly His Tyr Phe Lys Lys Arg Leu Gly Leu Val Asn Gly Ile
      50                  55                  60

 gtc act gct ggc agc agt gtc ttc aca atc ctg ctg cct ttg ctc tta      240
 Val Thr Ala Gly Ser Ser Val Phe Thr Ile Leu Leu Pro Leu Leu Leu
  65                  70                  75                  80

 agg gtt ctg att gac agc gtg ggc ctc ttt tac aca ttg agg gtg ctc      288
 Arg Val Leu Ile Asp Ser Val Gly Leu Phe Tyr Thr Leu Arg Val Leu
                  85                  90                  95

 tgc atc ttc atg ttt gtt ctc ttt ctg gct ggc ttt act tac cga cct      336
 Cys Ile Phe Met Phe Val Leu Phe Leu Ala Gly Phe Thr Tyr Arg Pro
             100                 105                 110

 ctt gct acc agt acc aaa gat aaa gag agt gga ggt agc gga tcc tcc      384
 Leu Ala Thr Ser Thr Lys Asp Lys Glu Ser Gly Gly Ser Gly Ser Ser
         115                 120                 125

 ctc ttt tcc agg aaa aag ttc agt cct cca aaa aaa att ttc aat ttt      432
 Leu Phe Ser Arg Lys Lys Phe Ser Pro Pro Lys Lys Ile Phe Asn Phe
     130                 135                 140

 gcc atc ttc aag gtg aca gct tat gca gtg tgg gca gtt gga ata cca      480
 Ala Ile Phe Lys Val Thr Ala Tyr Ala Val Trp Ala Val Gly Ile Pro
 145                 150                 155                 160

 ctt gca ctt ttt gga tac ttt gtg cct tat gtt cac ttg gca tgt ttt      528
 Leu Ala Leu Phe Gly Tyr Phe Val Pro Tyr Val His Leu Ala Cys Phe
                 165                 170                 175

 ctt aca aaa tat gtt gac att gtt cat ttg aga ttt tct ctt tct cat      576
 Leu Thr Lys Tyr Val Asp Ile Val His Leu Arg Phe Ser Leu Ser His
             180                 185                 190

 aac ggt gcc cgt tat cgc acc gaa tgc agc acg gta gag gaa aga tca      624
 Asn Gly Ala Arg Tyr Arg Thr Glu Cys Ser Thr Val Glu Glu Arg Ser
         195                 200                 205

 gat agc taa                                                          633
 Asp Ser 
     210





      <210> 501
      <211> 1146
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (106)..(1146)

      <400> 501
 atgtctgcag tcctcacccc tggcctgttc ctccccctcc cagggcccct cccggcctct     60

 ctacataaag ccgggggtac tgggcctcag gtcaggccta tggcc    atg gcc ttc     114
                                                      Met Ala Phe
                                                        1

 aca gac ctg ctg gat gct ctg ggc agc atg ggc cgc ttc cag ctc aac      162
 Thr Asp Leu Leu Asp Ala Leu Gly Ser Met Gly Arg Phe Gln Leu Asn
       5                  10                  15

 cac aca gcc ctg ctg ctg ctg ccc tgc ggc ctg ctg gcc tgc cac aac      210
 His Thr Ala Leu Leu Leu Leu Pro Cys Gly Leu Leu Ala Cys His Asn
  20                  25                  30                  35

 ttc ctg cag aac ttc acc gcc gct gtc ccc ccc cac cac tgc cgg ggc      258
 Phe Leu Gln Asn Phe Thr Ala Ala Val Pro Pro His His Cys Arg Gly
                  40                  45                  50

 cct gcc aac cac act gag gcc tcc acc aac gac tcg ggg gcc tgg ctg      306
 Pro Ala Asn His Thr Glu Ala Ser Thr Asn Asp Ser Gly Ala Trp Leu
              55                  60                  65

 agg gcc acc ata ccc ctg gac cag ctt ggg gcc cct gag ccc tgc cgg      354
 Arg Ala Thr Ile Pro Leu Asp Gln Leu Gly Ala Pro Glu Pro Cys Arg
          70                  75                  80

 cgc ttc acc aag cct cag tgg gcc ctg ctg agc ccc aac tcc tcc atc      402
 Arg Phe Thr Lys Pro Gln Trp Ala Leu Leu Ser Pro Asn Ser Ser Ile
      85                  90                  95

 ccg ggc gcg gcc acg gag ggc tgc aag gac ggc tgg gtc tat aac cgc      450
 Pro Gly Ala Ala Thr Glu Gly Cys Lys Asp Gly Trp Val Tyr Asn Arg
 100                 105                 110                 115

 agt gtt ttc ccg tcc acc atc gtg atg gag gtc aga agg ggc tgg gtg      498
 Ser Val Phe Pro Ser Thr Ile Val Met Glu Val Arg Arg Gly Trp Val
                 120                 125                 130

 tgt ggg ggg gct gct gcc gag gcc cag tct gaa gcg ccc atg tct tcc      546
 Cys Gly Gly Ala Ala Ala Glu Ala Gln Ser Glu Ala Pro Met Ser Ser
             135                 140                 145

 ctg cag tgg gat ctg gtg tgt gag gcc cgc act ctc cga gac ctg gcg      594
 Leu Gln Trp Asp Leu Val Cys Glu Ala Arg Thr Leu Arg Asp Leu Ala
         150                 155                 160

 cag tcc gtc tac att gcc ggg gtg ctg gtg ggg gct gcc gtg ttt ggc      642
 Gln Ser Val Tyr Ile Ala Gly Val Leu Val Gly Ala Ala Val Phe Gly
     165                 170                 175

 agc ttg gca gac agg ctg ggc tgc aag ggc ccc ctg gtc tgg tcc tac      690
 Ser Leu Ala Asp Arg Leu Gly Cys Lys Gly Pro Leu Val Trp Ser Tyr
 180                 185                 190                 195

 ctg cag ctg gca gct tcg ggg gcc gcc aca gcg tat ttc agc tcc ttc      738
 Leu Gln Leu Ala Ala Ser Gly Ala Ala Thr Ala Tyr Phe Ser Ser Phe
                 200                 205                 210

 agt gcc tat tgc gtc ttc cgg ttc ctg atg ggc atg acc ttc tct ggc      786
 Ser Ala Tyr Cys Val Phe Arg Phe Leu Met Gly Met Thr Phe Ser Gly
             215                 220                 225

 atc atc ctc aac tcc gtc tcc ctg ctg tca ctg gtc cac tgc ctg ata      834
 Ile Ile Leu Asn Ser Val Ser Leu Leu Ser Leu Val His Cys Leu Ile
         230                 235                 240

 gag agc ctc cta gtg cca gga gag gct cta gag gtt gcg gtg aac aca      882
 Glu Ser Leu Leu Val Pro Gly Glu Ala Leu Glu Val Ala Val Asn Thr
     245                 250                 255

 gcc ctg ctc ctt gga gtc cat gtt cta gcg agg cga gat atc acc agc      930
 Ala Leu Leu Leu Gly Val His Val Leu Ala Arg Arg Asp Ile Thr Ser
 260                 265                 270                 275

 atg cat aac gaa tcg tat agt atg ttc gaa gac att gtg gag tgg atg      978
 Met His Asn Glu Ser Tyr Ser Met Phe Glu Asp Ile Val Glu Trp Met
                 280                 285                 290

 ccc aca cgg ggc cgg act gtg gcg ggt att ttg ctg ggg tat tcc ttc     1026
 Pro Thr Arg Gly Arg Thr Val Ala Gly Ile Leu Leu Gly Tyr Ser Phe
             295                 300                 305

 acc ctg ggc cag ctc atc ctg gct ggg gta gcc tac ctg att cgc ccc     1074
 Thr Leu Gly Gln Leu Ile Leu Ala Gly Val Ala Tyr Leu Ile Arg Pro
         310                 315                 320

 tgg cgg tgc ctg cag ttt gcc atc tct gct cct ttc ctg atc ttt ttc     1122
 Trp Arg Cys Leu Gln Phe Ala Ile Ser Ala Pro Phe Leu Ile Phe Phe
     325                 330                 335

 ctc tat tct tgt ggt tgc agc tga                                     1146
 Leu Tyr Ser Cys Gly Cys Ser 
 340                 345





      <210> 502
      <211> 1821
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (1)..(1821)

      <400> 502
  atg ggg agc acg aaa gga tcc tct gtg ggt ttg gaa agg cca agg gcc      48
  Met Gly Ser Thr Lys Gly Ser Ser Val Gly Leu Glu Arg Pro Arg Ala
    1               5                  10                  15

 cgc gca gga tgc ccc cgg ccc ctg gca gcc ccc cgg gag gtc ctg agc       96
 Arg Ala Gly Cys Pro Arg Pro Leu Ala Ala Pro Arg Glu Val Leu Ser
              20                  25                  30

 tcg acg cgc ccc ctc tac gcc atg tcc ccc cct ggc tcg gcc gcg gga      144
 Ser Thr Arg Pro Leu Tyr Ala Met Ser Pro Pro Gly Ser Ala Ala Gly
          35                  40                  45

 gag agc gcc gcc ggc ggc ggc ggc ggc ggt ggc ggc ccc ggg gtc tcg      192
 Glu Ser Ala Ala Gly Gly Gly Gly Gly Gly Gly Gly Pro Gly Val Ser
      50                  55                  60

 gag gag ctc acg gcg gcg gcg gca gcg gcg gcg gcg gac gag ggc ccc      240
 Glu Glu Leu Thr Ala Ala Ala Ala Ala Ala Ala Ala Asp Glu Gly Pro
  65                  70                  75                  80

 gcc cga gag gag cag cag cgt ccc atc cag ccc tct ttc acc aag tcc      288
 Ala Arg Glu Glu Gln Gln Arg Pro Ile Gln Pro Ser Phe Thr Lys Ser
                  85                  90                  95

 ctc tgc cgt gag tcc cac tgg aag tgc ctc ctg ctc tcg ctg ctc atg      336
 Leu Cys Arg Glu Ser His Trp Lys Cys Leu Leu Leu Ser Leu Leu Met
             100                 105                 110

 tac ggc tgc ctg ggg gca gtg gcc tgg tgc cac gtc acc aca gtg acg      384
 Tyr Gly Cys Leu Gly Ala Val Ala Trp Cys His Val Thr Thr Val Thr
         115                 120                 125

 cgc ctc acc ttc agc agc gcc tac cag ggc aac agc ctc atg tac cat      432
 Arg Leu Thr Phe Ser Ser Ala Tyr Gln Gly Asn Ser Leu Met Tyr His
     130                 135                 140

 gac agc ccc tgc tcc aac ggc tat gtc tac atc ccc ctg gcc ttc ctg      480
 Asp Ser Pro Cys Ser Asn Gly Tyr Val Tyr Ile Pro Leu Ala Phe Leu
 145                 150                 155                 160

 ctc atg ttg tac gcc gtc tac ctg gtg gag tgt tgg cac tgc caa gcc      528
 Leu Met Leu Tyr Ala Val Tyr Leu Val Glu Cys Trp His Cys Gln Ala
                 165                 170                 175

 cgc cat gag ctg cag cac cgt gtt gat gtg agc agt gtg cgg gaa cgt      576
 Arg His Glu Leu Gln His Arg Val Asp Val Ser Ser Val Arg Glu Arg
             180                 185                 190

 gtg ggc cgc atg cag caa gcc acg ccc tgc atc tgg tgg aag gcc atc      624
 Val Gly Arg Met Gln Gln Ala Thr Pro Cys Ile Trp Trp Lys Ala Ile
         195                 200                 205

 agc tac cac tat gtc cgc cgc acc cgc cag gtc acc aga tac cgc aat      672
 Ser Tyr His Tyr Val Arg Arg Thr Arg Gln Val Thr Arg Tyr Arg Asn
     210                 215                 220

 gga gac gcc tat acc acc acc cag gtc tac cac gaa cgc gtc aac acg      720
 Gly Asp Ala Tyr Thr Thr Thr Gln Val Tyr His Glu Arg Val Asn Thr
 225                 230                 235                 240

 cac gtg gcg gag gct gag ttc gac tac gcg cgc tgc ggc gtt cgc gac      768
 His Val Ala Glu Ala Glu Phe Asp Tyr Ala Arg Cys Gly Val Arg Asp
                 245                 250                 255

 gtg tcc aag acg ctg gtg ggg ctg gag ggc gcg ccg gcc acg cgg ctg      816
 Val Ser Lys Thr Leu Val Gly Leu Glu Gly Ala Pro Ala Thr Arg Leu
             260                 265                 270

 cgc ttc acc aag tgc ttc agt ttc gcc agc gtg gag gcc gag aac gcg      864
 Arg Phe Thr Lys Cys Phe Ser Phe Ala Ser Val Glu Ala Glu Asn Ala
         275                 280                 285

 tac ctg tgc cag cgc gcg cgc ttc ttc gca gag aac gag ggc cta gac      912
 Tyr Leu Cys Gln Arg Ala Arg Phe Phe Ala Glu Asn Glu Gly Leu Asp
     290                 295                 300

 gac tac atg gag gca cgc gag ggc atg cac ctc aag aac gtg gac ttc      960
 Asp Tyr Met Glu Ala Arg Glu Gly Met His Leu Lys Asn Val Asp Phe
 305                 310                 315                 320

 cgt gag ttc atg gtg gcc ttc ccg gac ccg gcc cgg ccg ccc tgg tac     1008
 Arg Glu Phe Met Val Ala Phe Pro Asp Pro Ala Arg Pro Pro Trp Tyr
                 325                 330                 335

 gcc tgc tcg tcg gcc ttc tgg gcc gcg gcg ctg ctc acg ctg tcg tgg     1056
 Ala Cys Ser Ser Ala Phe Trp Ala Ala Ala Leu Leu Thr Leu Ser Trp
             340                 345                 350

 ccg ctg cga gtg ctg gcc gag tac cgc acg gcc tac gcg cac tac cac     1104
 Pro Leu Arg Val Leu Ala Glu Tyr Arg Thr Ala Tyr Ala His Tyr His
         355                 360                 365

 gtg gag aag cta ttt ggc ctg gag ggc ccg ggc tcg gcc agc agc gca     1152
 Val Glu Lys Leu Phe Gly Leu Glu Gly Pro Gly Ser Ala Ser Ser Ala
     370                 375                 380

 ggc ggt ggc ctc agc ccc agc gat gag ctg ctg ccc ccg ctc acc cac     1200
 Gly Gly Gly Leu Ser Pro Ser Asp Glu Leu Leu Pro Pro Leu Thr His
 385                 390                 395                 400

 cgc ctg ccg cgg gtc aac aca gta gac agc acg gag ctc gag tgg cac     1248
 Arg Leu Pro Arg Val Asn Thr Val Asp Ser Thr Glu Leu Glu Trp His
                 405                 410                 415

 atc cgc tcc aac cag cag ctg gtg ccc agc tac tct gag gcg gtg ctc     1296
 Ile Arg Ser Asn Gln Gln Leu Val Pro Ser Tyr Ser Glu Ala Val Leu
             420                 425                 430

 atg gac ctg gcg ggg ctc ggg acg cgc tgc ggc ggg gca ggc ggc ggc     1344
 Met Asp Leu Ala Gly Leu Gly Thr Arg Cys Gly Gly Ala Gly Gly Gly
         435                 440                 445

 tac gcg ccc tcg tgc cgc tac ggt ggg gta ggc ggc ccg ggc gcg gcg     1392
 Tyr Ala Pro Ser Cys Arg Tyr Gly Gly Val Gly Gly Pro Gly Ala Ala
     450                 455                 460

 ggc gtg gct ccc tac cgg cgc agc tgc gag cac tgc cag cgc gcc gtc     1440
 Gly Val Ala Pro Tyr Arg Arg Ser Cys Glu His Cys Gln Arg Ala Val
 465                 470                 475                 480

 agc agc tcg tct atc ttc tcg cgc agc gcc cta agc atc tgc gcc agc     1488
 Ser Ser Ser Ser Ile Phe Ser Arg Ser Ala Leu Ser Ile Cys Ala Ser
                 485                 490                 495

 ccg cgg gcc ggc ccg ggg ccc ggt ggg ggc gcg ggc tgc ggg ggc agc     1536
 Pro Arg Ala Gly Pro Gly Pro Gly Gly Gly Ala Gly Cys Gly Gly Ser
             500                 505                 510

 cgc ttc tcg ctg ggc cgt ctc tac ggc tcc cgg cgc agc tgc ctg tgg     1584
 Arg Phe Ser Leu Gly Arg Leu Tyr Gly Ser Arg Arg Ser Cys Leu Trp
         515                 520                 525

 cgc agc cgc agc ggg agc gtc aac gag gcc agc tgc ccc acg gag cag     1632
 Arg Ser Arg Ser Gly Ser Val Asn Glu Ala Ser Cys Pro Thr Glu Gln
     530                 535                 540

 acg cgg ctg tcc agc cag gcc agc atg ggg gac gac gag gac gac gac     1680
 Thr Arg Leu Ser Ser Gln Ala Ser Met Gly Asp Asp Glu Asp Asp Asp
 545                 550                 555                 560

 gag gag gag gcc ggg ccg ccg ccg ccc tac cac gac gcc ctc tac ttt     1728
 Glu Glu Glu Ala Gly Pro Pro Pro Pro Tyr His Asp Ala Leu Tyr Phe
                 565                 570                 575

 ccg gtc ctc atc gtc cac cgg cag gag ggg tgt ctg ggc cac agc cac     1776
 Pro Val Leu Ile Val His Arg Gln Glu Gly Cys Leu Gly His Ser His
             580                 585                 590

 cgg ccg ctg cac cgc cac ggc tcc tgc gta gag acc tca ctg tga         1821
 Arg Pro Leu His Arg His Gly Ser Cys Val Glu Thr Ser Leu 
         595                 600                 605





      <210> 503
      <211> 1510
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (318)..(1334)

      <400> 503
 cttagggagt gagtgtggcc gggccttctc ctgtggcggg tgttggggag cggagcccag     60

 agctcctgtg gggccgctgc tttggcggtg ggcccagccg ggagcagcct ctttcgaagg    120

 ccgccgtgac ctcttcaagg gcgtggagac gggaaggaaa aggccccggt tggggttcca    180

 gggcgccggt aacgttaacc ggcgccttgc ctgtcctcta accgtcgctc cctcctcccc    240

 tagaaagatg ttctcgtccg tggcgcacct ggcgcgggcg aaccccttca acacgccaca    300

 tctgcagctg gtgcacg   atg gtc tcg ggg acc tcc gca gca gct ccc cag     350
                      Met Val Ser Gly Thr Ser Ala Ala Ala Pro Gln
                        1               5                  10

 ggc cca cgg gcc agc ccc gcc gcc ctc gca acc tgg cag ccg ccg ccg      398
 Gly Pro Arg Ala Ser Pro Ala Ala Leu Ala Thr Trp Gln Pro Pro Pro
              15                  20                  25

 tgg aag agt aca gtt gtg aat ttg gct ccg cga agt att atg cac tgt      446
 Trp Lys Ser Thr Val Val Asn Leu Ala Pro Arg Ser Ile Met His Cys
          30                  35                  40

 gtg gct ttg gct ggg gtc tta agt tgt ggt ctg aca cac act gct gtg      494
 Val Ala Leu Ala Gly Val Leu Ser Cys Gly Leu Thr His Thr Ala Val
      45                  50                  55

 gtt ccc ctg gat tta gtg aaa tgc cgt atg cag gtg gac ccc caa aag      542
 Val Pro Leu Asp Leu Val Lys Cys Arg Met Gln Val Asp Pro Gln Lys
  60                  65                  70                  75

 tac aag ggc ata ttt aac gga ttc tca gtt aca ctt aaa gag gat ggt      590
 Tyr Lys Gly Ile Phe Asn Gly Phe Ser Val Thr Leu Lys Glu Asp Gly
                  80                  85                  90

 gtt cgt ggt ttg gct aaa gga tgg gct ccg act ttc ctt ggc tac tcc      638
 Val Arg Gly Leu Ala Lys Gly Trp Ala Pro Thr Phe Leu Gly Tyr Ser
              95                 100                 105

 atg cag gga ctc tgc aag ttt ggc ttt tat gaa gtc ttt aaa gtc ttg      686
 Met Gln Gly Leu Cys Lys Phe Gly Phe Tyr Glu Val Phe Lys Val Leu
         110                 115                 120

 tat agc aat atg ctt gga gag gag aat act tat ctc tgg cgc aca tca      734
 Tyr Ser Asn Met Leu Gly Glu Glu Asn Thr Tyr Leu Trp Arg Thr Ser
     125                 130                 135

 cta tat ttg gct gcc tct gcc agt gct gaa ttc ttt gct gac att gcc      782
 Leu Tyr Leu Ala Ala Ser Ala Ser Ala Glu Phe Phe Ala Asp Ile Ala
 140                 145                 150                 155

 ctg gct cct atg gaa gct gct aag gtt cga att caa acc cag cca ggt      830
 Leu Ala Pro Met Glu Ala Ala Lys Val Arg Ile Gln Thr Gln Pro Gly
                 160                 165                 170

 tat gcc aac act ttg agg gat gca gct ccc aaa atg tat aag gaa gaa      878
 Tyr Ala Asn Thr Leu Arg Asp Ala Ala Pro Lys Met Tyr Lys Glu Glu
             175                 180                 185

 ggc cta aaa gca ttc tac aag ggg gtt gct cct ctc tgg atg aga cag      926
 Gly Leu Lys Ala Phe Tyr Lys Gly Val Ala Pro Leu Trp Met Arg Gln
         190                 195                 200

 ata cca tac acc atg atg aag ttc gcc tgc ttt gaa cgt act gtt gaa      974
 Ile Pro Tyr Thr Met Met Lys Phe Ala Cys Phe Glu Arg Thr Val Glu
     205                 210                 215

 gca ctg tac aag ttt gtg gtt cct aag ccc cgc agt gaa tgt tca aag     1022
 Ala Leu Tyr Lys Phe Val Val Pro Lys Pro Arg Ser Glu Cys Ser Lys
 220                 225                 230                 235

 cca gag cag ctg gtt gta aca ttt gta gca ggt tac ata gct gga gtc     1070
 Pro Glu Gln Leu Val Val Thr Phe Val Ala Gly Tyr Ile Ala Gly Val
                 240                 245                 250

 ttt tgt gca att gtt tct cac cct gct gat tct gtg gta tct gtg ttg     1118
 Phe Cys Ala Ile Val Ser His Pro Ala Asp Ser Val Val Ser Val Leu
             255                 260                 265

 aat aaa gaa aaa ggt agc agt gct tct ctg gtc ctc aag aga ctt gga     1166
 Asn Lys Glu Lys Gly Ser Ser Ala Ser Leu Val Leu Lys Arg Leu Gly
         270                 275                 280

 ttt aaa ggt gta tgg aag gga ctg ttt gcc cgt atc atc atg att ggt     1214
 Phe Lys Gly Val Trp Lys Gly Leu Phe Ala Arg Ile Ile Met Ile Gly
     285                 290                 295

 acc ctg act gca cta cag tgg ttt atc tat gac tcc gtg aag gtc tac     1262
 Thr Leu Thr Ala Leu Gln Trp Phe Ile Tyr Asp Ser Val Lys Val Tyr
 300                 305                 310                 315

 ttc aga ctt cct cgc cct cct cca ccc gag atg cca gag tct ctg aag     1310
 Phe Arg Leu Pro Arg Pro Pro Pro Pro Glu Met Pro Glu Ser Leu Lys
                 320                 325                 330

 aag aag ctt ggg tta act cag tag ttagatcaaa gcaaatgtgg actgaatctg    1364
 Lys Lys Leu Gly Leu Thr Gln 
             335

 cttgttgatc agtgttgaag aaagtgcaaa aggaactttt atatatttga cagtgtagga   1424

 aattgtctat tcctgatata attactgtag tactcttgct taaggcacag agtttcagat   1484

 ttactgttga aataaacccc actctt                                        1510




      <210> 504
      <211> 1256
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (1)..(1209)

      <400> 504
  atg gaa gga ggg gac ctt tgt gag acg ggt gac gca gag cca gtg ctg      48
  Met Glu Gly Gly Asp Leu Cys Glu Thr Gly Asp Ala Glu Pro Val Leu
    1               5                  10                  15

 gga gag tgt cac gtg gca gag aac tcg gat tct tca tcg ggc ttc gga       96
 Gly Glu Cys His Val Ala Glu Asn Ser Asp Ser Ser Ser Gly Phe Gly
              20                  25                  30

 gag ttg tgg gga gtt ggg cag gtc ccg ggg aga gac gag cag aag cct      144
 Glu Leu Trp Gly Val Gly Gln Val Pro Gly Arg Asp Glu Gln Lys Pro
          35                  40                  45

 gat cgt ggt gta tgt ggg cgt ctc ctc agc cgg cag ctt cac tgt gcc      192
 Asp Arg Gly Val Cys Gly Arg Leu Leu Ser Arg Gln Leu His Cys Ala
      50                  55                  60

 ctg cgg ttg atg tcc aag gtt ttg act gtg tgg gtt tgt gtc ttt ccg      240
 Leu Arg Leu Met Ser Lys Val Leu Thr Val Trp Val Cys Val Phe Pro
  65                  70                  75                  80

 gca ggt gtc tcc tct gtg act tcc ctg atg tcc ctg gct tgg gtg cta      288
 Ala Gly Val Ser Ser Val Thr Ser Leu Met Ser Leu Ala Trp Val Leu
                  85                  90                  95

 gcc tcc tat cac aag ctg ctg cgg gac tcc agg gac gac aag aag agc      336
 Ala Ser Tyr His Lys Leu Leu Arg Asp Ser Arg Asp Asp Lys Lys Ser
             100                 105                 110

 atg agc tac aga ggg gcc atc atc cag gtc ttc tgg cgc ctc ttc acc      384
 Met Ser Tyr Arg Gly Ala Ile Ile Gln Val Phe Trp Arg Leu Phe Thr
         115                 120                 125

 atc tca tcc cga gtg atc tct ttt gcc ctc ttt gct tcc atc ttc cag      432
 Ile Ser Ser Arg Val Ile Ser Phe Ala Leu Phe Ala Ser Ile Phe Gln
     130                 135                 140

 ctc tat ttt ggg atc ttc gtg gtg gtt cac tgg tgc gcc atg gcc ttc      480
 Leu Tyr Phe Gly Ile Phe Val Val Val His Trp Cys Ala Met Ala Phe
 145                 150                 155                 160

 tgg atc atc cat ggc gga aca gac ttc tgc atg tcc aag tgg gag gag      528
 Trp Ile Ile His Gly Gly Thr Asp Phe Cys Met Ser Lys Trp Glu Glu
                 165                 170                 175

 atc ctc ttc aac atg gtg gta ggg atc gtg tac att ttc tgc tgg ttt      576
 Ile Leu Phe Asn Met Val Val Gly Ile Val Tyr Ile Phe Cys Trp Phe
             180                 185                 190

 aac gtc aag gaa ggg cgg act cga tat cga atg ttt gca tat tat acg      624
 Asn Val Lys Glu Gly Arg Thr Arg Tyr Arg Met Phe Ala Tyr Tyr Thr
         195                 200                 205

 ata gtc ttg acc gag aat gct gcc ttg acg ttc ctt tgg tat ttt tac      672
 Ile Val Leu Thr Glu Asn Ala Ala Leu Thr Phe Leu Trp Tyr Phe Tyr
     210                 215                 220

 aga gac ccg gag acc act gac tcc tat gcg gtg cca gca ctg tgt tgt      720
 Arg Asp Pro Glu Thr Thr Asp Ser Tyr Ala Val Pro Ala Leu Cys Cys
 225                 230                 235                 240

 gtc ttt att agc ttt gtg gct ggg atc gca atg atg ctc tta tac tat      768
 Val Phe Ile Ser Phe Val Ala Gly Ile Ala Met Met Leu Leu Tyr Tyr
                 245                 250                 255

 ggc gtg ctg cat ccc aca gga cca cga gct aag atc ctt gcc agc tcc      816
 Gly Val Leu His Pro Thr Gly Pro Arg Ala Lys Ile Leu Ala Ser Ser
             260                 265                 270

 tgt tgt gcc gag ctg ctc tgg ggc atc cct ttg ccc ccc gat gtt gag      864
 Cys Cys Ala Glu Leu Leu Trp Gly Ile Pro Leu Pro Pro Asp Val Glu
         275                 280                 285

 ccc atg gcg cct gag atc cct ggg tac cgg ggg acc cag gtt acg ccc      912
 Pro Met Ala Pro Glu Ile Pro Gly Tyr Arg Gly Thr Gln Val Thr Pro
     290                 295                 300

 acc aga gcc gta acg gaa caa cag gag gat ctc acg gct gac act tgc      960
 Thr Arg Ala Val Thr Glu Gln Gln Glu Asp Leu Thr Ala Asp Thr Cys
 305                 310                 315                 320

 ttg cct gtt ttc caa gtg aga ccc atg ggg ccc cct acc ccg ttg ggg     1008
 Leu Pro Val Phe Gln Val Arg Pro Met Gly Pro Pro Thr Pro Leu Gly
                 325                 330                 335

 cgt cct tac ctc cca gaa ggg ccc ctc att aag att gac atg cca aga     1056
 Arg Pro Tyr Leu Pro Glu Gly Pro Leu Ile Lys Ile Asp Met Pro Arg
             340                 345                 350

 aag cga tac cca gct tgg gat gct cat ttt gta gac agg agg ctg aga     1104
 Lys Arg Tyr Pro Ala Trp Asp Ala His Phe Val Asp Arg Arg Leu Arg
         355                 360                 365

 agg act att aac att cta caa tat gtc acc ccc acc gca gta ggc att     1152
 Arg Thr Ile Asn Ile Leu Gln Tyr Val Thr Pro Thr Ala Val Gly Ile
     370                 375                 380

 cga tat cga gac gga cca ctc ctc tat gag ttg cta cag tat gag tct     1200
 Arg Tyr Arg Asp Gly Pro Leu Leu Tyr Glu Leu Leu Gln Tyr Glu Ser
 385                 390                 395                 400

 tca ctc taa gagcatc ttgaccaagt tgagaagggg accttaagtt tggtttgcgg     1256
 Ser Leu 






      <210> 505
      <211> 1415
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (528)..(1334)

      <400> 505
 ggctgtaaaa ttggccccgg ggttaggaac aatgactttt ccactgcaag actgttgata     60

 tcagtccccc tctatattct gtgcaaaggg tgtctttgac tcatccaaaa aattgaacag    120

 tttcctgtct catggagatc tatcacaaag tctttaaata ttactaccca tgaaattggc    180

 cagggttagg acattcaaat gtctttatcc acattcctga aggataattg ttatagattc    240

 cctacctcca taggaatgct tataatggat tatctataca atctccacat tcccacattt    300

 tgcattagag aatggaatca gtcaaaccct gttcccagag tttcccttag agttctcacc    360

 tgttgtctta tatccatcta ggaatcccca tctctaatgt aagcttggag atccgggccc    420

 ccgggggaca ggtgactgaa ggacaaaaac tgatcctgct ctgctcagtg gctgggggta    480

 caggaaatgt cacattctcc tggtacagag aggccacagg aaccagt  atg gga aag     536
                                                      Met Gly Lys
                                                        1

 aaa acc cag cgt tcc ctg tca gca gag ctg gag atc cca gct gtg aaa      584
 Lys Thr Gln Arg Ser Leu Ser Ala Glu Leu Glu Ile Pro Ala Val Lys
       5                  10                  15

 gag agt gat gcc ggc aaa tat tac tgt aga gct gac aac ggc cat gtg      632
 Glu Ser Asp Ala Gly Lys Tyr Tyr Cys Arg Ala Asp Asn Gly His Val
  20                  25                  30                  35

 cct atc cag agc aag gtg gtg aat atc cct gtg aga agt ctc ctg ggg      680
 Pro Ile Gln Ser Lys Val Val Asn Ile Pro Val Arg Ser Leu Leu Gly
                  40                  45                  50

 ccc cag gct gca ggg ggg gac ctg ctg gag ctt cac tgt gag gcc ctg      728
 Pro Gln Ala Ala Gly Gly Asp Leu Leu Glu Leu His Cys Glu Ala Leu
              55                  60                  65

 aga ggc tct ccc ctg atc ttg tac cgg ttt ttt cat gag gat gtc acc      776
 Arg Gly Ser Pro Leu Ile Leu Tyr Arg Phe Phe His Glu Asp Val Thr
          70                  75                  80

 cta gga aat agg tcg tcc ccc tct gga gga gcg tcc tta aac ctc tct      824
 Leu Gly Asn Arg Ser Ser Pro Ser Gly Gly Ala Ser Leu Asn Leu Ser
      85                  90                  95

 ctg act gca gag cac tct gga aac tac tcc tgt gag gcc gac aat ggc      872
 Leu Thr Ala Glu His Ser Gly Asn Tyr Ser Cys Glu Ala Asp Asn Gly
 100                 105                 110                 115

 ctc ggg gcc cag cgc agt gag aca gtg aca ctt tat atc aca ggg ctg      920
 Leu Gly Ala Gln Arg Ser Glu Thr Val Thr Leu Tyr Ile Thr Gly Leu
                 120                 125                 130

 acc gcg aac aga agt ggc cct ttt gcc aca gga gtc gcc ggg ggc ctg      968
 Thr Ala Asn Arg Ser Gly Pro Phe Ala Thr Gly Val Ala Gly Gly Leu
             135                 140                 145

 ctc agc ata gca ggc ctt gct gcg ggg gca ctg ctg ctc tac tgc tgg     1016
 Leu Ser Ile Ala Gly Leu Ala Ala Gly Ala Leu Leu Leu Tyr Cys Trp
         150                 155                 160

 ctc tcg aga aaa gca ggg aga aag cct gcc tct gac ccc gcc agg agc     1064
 Leu Ser Arg Lys Ala Gly Arg Lys Pro Ala Ser Asp Pro Ala Arg Ser
     165                 170                 175

 cct tca gac tcg gac tcc caa gag ccc acc tat cac aat gta cca gcc     1112
 Pro Ser Asp Ser Asp Ser Gln Glu Pro Thr Tyr His Asn Val Pro Ala
 180                 185                 190                 195

 tgg gaa gag ctg caa cca gtg tac act aat gca aat cct aga gga gaa     1160
 Trp Glu Glu Leu Gln Pro Val Tyr Thr Asn Ala Asn Pro Arg Gly Glu
                 200                 205                 210

 aat gtg gtt tac tca gaa gta cgg atc atc caa aaa aaa aaa aaa cat     1208
 Asn Val Val Tyr Ser Glu Val Arg Ile Ile Gln Lys Lys Lys Lys His
             215                 220                 225

 gca gtg gcc tct gac ccc agg cat ctc agg aac aag ggt tcc cct atc     1256
 Ala Val Ala Ser Asp Pro Arg His Leu Arg Asn Lys Gly Ser Pro Ile
         230                 235                 240

 atc tac tct gaa gtt aag gtg gcg tca acc ccg gtt tcc gga tcc ctg     1304
 Ile Tyr Ser Glu Val Lys Val Ala Ser Thr Pro Val Ser Gly Ser Leu
     245                 250                 255

 ttc ttg gct tcc tca gct cct cac aga tga g tccacacgtc tctccaactg     1355
 Phe Leu Ala Ser Ser Ala Pro His Arg 
 260                 265

 ctgtttcagc ctctgcaccc caaagttccc cttgggggag aagcagcatt gaagtgggag   1415




      <210> 506
      <211> 654
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (116)..(604)

      <400> 506
 aaggatcctt aattaaatta atcccccccc ccccccggtg gtttctggtt tgttggggcg     60

 tgtgtatgtg tatttggggg gactgaaggg tacgtggggc gaaacaaaac cggcc atg     118
                                                              Met
                                                                1

 gca gca gcg gag gag gag gac ggg ggc ccc gaa ggg cca aat cgc gag      166
 Ala Ala Ala Glu Glu Glu Asp Gly Gly Pro Glu Gly Pro Asn Arg Glu
               5                  10                  15

 cgg ggc ggg gcg ggc gcg acc ttc gaa tgt aat ata tgt ttg gag act      214
 Arg Gly Gly Ala Gly Ala Thr Phe Glu Cys Asn Ile Cys Leu Glu Thr
          20                  25                  30

 gct cgg gaa gct gtg gtc agt gtg tgt ggc cac ctg tac tgt tgg cca      262
 Ala Arg Glu Ala Val Val Ser Val Cys Gly His Leu Tyr Cys Trp Pro
      35                  40                  45

 tgt ctt cat cag tgg ctg gag aca cgg cca gaa cgg caa gag tgt cca      310
 Cys Leu His Gln Trp Leu Glu Thr Arg Pro Glu Arg Gln Glu Cys Pro
  50                  55                  60                  65

 gta tgt aaa gct ggg atc agc aga gag aag gtt gtc ccg ctt tat ggg      358
 Val Cys Lys Ala Gly Ile Ser Arg Glu Lys Val Val Pro Leu Tyr Gly
                  70                  75                  80

 cga ggg agc cag aag ccc cag gat ccc aga tta ttc cag cca ttt ggt      406
 Arg Gly Ser Gln Lys Pro Gln Asp Pro Arg Leu Phe Gln Pro Phe Gly
              85                  90                  95

 gat acc ggg ggc ttc cac ttc tca ttt ggt gtt ggt gct ttt ccc ttt      454
 Asp Thr Gly Gly Phe His Phe Ser Phe Gly Val Gly Ala Phe Pro Phe
         100                 105                 110

 ggc ttt ttc acc acc gtc ttc aat gcc cat gag cct ttc cgc cgg ggt      502
 Gly Phe Phe Thr Thr Val Phe Asn Ala His Glu Pro Phe Arg Arg Gly
     115                 120                 125

 aca ggt gtg gat ctg gga cag ggt cac cca gcc tcc agc tgg cag gat      550
 Thr Gly Val Asp Leu Gly Gln Gly His Pro Ala Ser Ser Trp Gln Asp
 130                 135                 140                 145

 tcc ctc ttc ctg ttt ctc gcc atc ttc ttc ttt ttt tgg ctg ctc agt      598
 Ser Leu Phe Leu Phe Leu Ala Ile Phe Phe Phe Phe Trp Leu Leu Ser
                 150                 155                 160

 att tga gctatgtctg cttcctgccc acctccagcc agagaagaat cagtattgag       654
 Ile 






      <210> 507
      <211> 2285
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (632)..(1450)

      <400> 507
 tcacagccct gatcgtgcct tttgagaatc ttttacgttc tggatattct ggtatggaag     60

 aggagaaaaa ccggcgctgg gcagtttgca atccaggaaa atagggaagg ataaacctga    120

 agcctgtgcg tccaggtgcg cctggctagg gtttccgacg gccgcggtgt ctcggtgggg    180

 accggtcccg gaggcttcgg cgaggaggac ccggagtccc ccccgccccg cggcggaact    240

 aaccacggag gcctctggtc cctttaaggt gcccggcgag cggagaaagg gagcagaggg    300

 ggcgggagga gggttcggga gcgcacgcca cgtgacccgg cggccaagtt cgctgcgagt    360

 ttgacagaag tttgaatccg agtcgggggc tttctgctgc cggcggggca ccgcggcggc    420

 cgcagcctct gagagcacga acagcagcgc ccccgcgtcc cagccagcca gccagccaga    480

 ctggactccg gcccaccgac ggccgctcgc gctccggccc cgctcgcctg ctctgccccg    540

 gacctgcagc tccccgctcc cccgccgtgt ccgccgcctc ccggccagag agccaagccc    600

 ccacgccgcg cccagcgctc gccgcgccag c   atg tcc tcg acc gag agc gcc     652
                                      Met Ser Ser Thr Glu Ser Ala
                                        1               5

 ggc cgc acg gcg gac aag tcg ccg cgc cag cag gtg gac cgc cta ctc      700
 Gly Arg Thr Ala Asp Lys Ser Pro Arg Gln Gln Val Asp Arg Leu Leu
          10                  15                  20

 gtg ggg ctg cgc tgg cgg cgg ctg gag gag ccg ctg ggc ttc atc aaa      748
 Val Gly Leu Arg Trp Arg Arg Leu Glu Glu Pro Leu Gly Phe Ile Lys
      25                  30                  35

 gtt ctc cag tgg ctc ttt gct att ttc gcc ttc ggg tcc tgt ggc tcc      796
 Val Leu Gln Trp Leu Phe Ala Ile Phe Ala Phe Gly Ser Cys Gly Ser
  40                  45                  50                  55

 tac agc ggg gag aca gga gca atg gtt cgc tgc aac aac gaa gcc aag      844
 Tyr Ser Gly Glu Thr Gly Ala Met Val Arg Cys Asn Asn Glu Ala Lys
                  60                  65                  70

 gac gtg agc tcc atc atc gtt gca ttt ggc tat ccc ttc agg ttg cac      892
 Asp Val Ser Ser Ile Ile Val Ala Phe Gly Tyr Pro Phe Arg Leu His
              75                  80                  85

 cgg atc caa tat gag atg ccc ctc tgc gat gaa gag tcc agc tcc aag      940
 Arg Ile Gln Tyr Glu Met Pro Leu Cys Asp Glu Glu Ser Ser Ser Lys
          90                  95                 100

 acc atg cac ctc atg ggg gac ttc tct gca ccc gcc gag ttc ttc gtg      988
 Thr Met His Leu Met Gly Asp Phe Ser Ala Pro Ala Glu Phe Phe Val
     105                 110                 115

 acc ctt ggc atc ttt tcc ttc ttc tat acc atg gct gcc cta gtt atc     1036
 Thr Leu Gly Ile Phe Ser Phe Phe Tyr Thr Met Ala Ala Leu Val Ile
 120                 125                 130                 135

 tac ctg cgc ttc cac aac ctc tac aca gag aac aaa cgc ttc ccg ctg     1084
 Tyr Leu Arg Phe His Asn Leu Tyr Thr Glu Asn Lys Arg Phe Pro Leu
                 140                 145                 150

 gtg gac ttc tgt gtg act gtc tcc ttc acc ttc ttc tgg ctg gta gct     1132
 Val Asp Phe Cys Val Thr Val Ser Phe Thr Phe Phe Trp Leu Val Ala
             155                 160                 165

 gca gct gcc tgg ggc aag ggc ctg acc gat gtc aag ggg gcc aca cga     1180
 Ala Ala Ala Trp Gly Lys Gly Leu Thr Asp Val Lys Gly Ala Thr Arg
         170                 175                 180

 cca tcc agc ttg aca gca gcc atg tca gtg tgc cat gga gag gaa gca     1228
 Pro Ser Ser Leu Thr Ala Ala Met Ser Val Cys His Gly Glu Glu Ala
     185                 190                 195

 gtg tgc agt gcc ggg gcc acg ccc tct atg ggc ctg gcc aac atc tcc     1276
 Val Cys Ser Ala Gly Ala Thr Pro Ser Met Gly Leu Ala Asn Ile Ser
 200                 205                 210                 215

 gtg ctc ttt ggc ttt atc aac ttc ttc ctg tgg gcc ggg aac tgt tgg     1324
 Val Leu Phe Gly Phe Ile Asn Phe Phe Leu Trp Ala Gly Asn Cys Trp
                 220                 225                 230

 ttt gtg ttc aag gag acc ccg tgg cat gga cag ggc cag ggc cag gac     1372
 Phe Val Phe Lys Glu Thr Pro Trp His Gly Gln Gly Gln Gly Gln Asp
             235                 240                 245

 cag gac cag gac cag gac cag ggc cag ggt ccc agc cag gag agt gca     1420
 Gln Asp Gln Asp Gln Asp Gln Gly Gln Gly Pro Ser Gln Glu Ser Ala
         250                 255                 260

 gct gag cag gga gca gtg gag aag cag taa g cagcccccca cctggctatt     1471
 Ala Glu Gln Gly Ala Val Glu Lys Gln 
     265                 270

 cccgaactgg acagcacctc ttcaaccacc tccggcttcc aggacctttc tcttcctcct   1531

 cctccaattc ccctccccca tcattctggt ctttgagctt tgagacgatg ggcaggcatc   1591

 agctgttgga aacctgggca gccctctcag tggcttccta tcctccttct tgctggagcc   1651

 atgaatggca ggagctcagt gcttcttgtg cagtgcctgg acccaggtat cttacttggg   1711

 gtcttacttg tacccttaca gtctctgaga accagcctct gctgcaggtg agggttgggg   1771

 gcaggaaacc agtgctctga gactggttcc tagcagccac ctttctgtca acctgtccgg   1831

 cttcaacaat attaggggga agggaaatca gctagtagcc ttcccctctg gtcccttgtg   1891

 tggaggcccc aatagtggtt tgggacccct cctcagtggc tgtcatctag tccctgcgtc   1951

 tgatctccag tcattcccaa tgaactcatg ttgtgcctat ccaacttgtg tttttctggg   2011

 cctcttggct tgcccactga atccaccatt gtggttgacc caagagaagg tcaaccaggc   2071

 taagaaaaaa agccttaaag gctctgatga ggcctcctgg atctcgttgg aaccagcata   2131

 attgggatta ggttggggtt caaaagaaag cgcgcagctg tggggaacca ttttgaatgc   2191

 ctaacttcga ccgcgagttg tggctttcac agtttggcta ttaagagcca tctccggctc   2251

 ttggcgcccg accaactggg gcgagcaccc aggg                               2285




      <210> 508
      <211> 1588
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (383)..(940)

      <400> 508
 gaaaagttcg aagtgggatg atcacgggca gacctgggtg gttgggaaca ggaagcatat     60

 ggcatcttgc aggctatagg caccacaaaa tggaacgcag gaggacaggg gcttgggaga    120

 gccacttcac tgtcgggtaa aacaacggag caagatgagt gcctccggat gcttggtttc    180

 cccaccctcc agtgtctgct tgctcttcaa gtacctccac caagctaatg acagtccact    240

 ttaggacatc acgggcctcg aggttacaac tttcccaggc tttgttattt ggttctctac    300

 tgcacagaaa tagatagaat tctgacagcc atcattgtta aacatcagga ttttctaaga    360

 ggacagactt aacagtaaca tc atg gcc tca gca gga ctc cag ctc ctt gct     412
                          Met Ala Ser Ala Gly Leu Gln Leu Leu Ala
                            1               5                  10

 ttc atc ctg gcc tta tcc ggg gtc tct gga gtg ctc aca gcc act ctg      460
 Phe Ile Leu Ala Leu Ser Gly Val Ser Gly Val Leu Thr Ala Thr Leu
                  15                  20                  25

 ctg ccc aac tgg aag gtg aat gtg gat gtg gac tcc aac atc ata aca      508
 Leu Pro Asn Trp Lys Val Asn Val Asp Val Asp Ser Asn Ile Ile Thr
              30                  35                  40

 gcc att gta cag ctg cac ggg ctc tgg atg gac tgt acg tgg tac agc      556
 Ala Ile Val Gln Leu His Gly Leu Trp Met Asp Cys Thr Trp Tyr Ser
          45                  50                  55

 act ggg atg ttc agc tgt gcc ctg aaa cac tcc att ctg tcc ctc ccc      604
 Thr Gly Met Phe Ser Cys Ala Leu Lys His Ser Ile Leu Ser Leu Pro
      60                  65                  70

 atc cac gtg cag gct gcg aga gcc acc atg gtc ctg gcg tgt gtt ctg      652
 Ile His Val Gln Ala Ala Arg Ala Thr Met Val Leu Ala Cys Val Leu
  75                  80                  85                  90

 tct gct ttg ggg atc tgc act tcc aca gta gga atg aaa tgt act cgc      700
 Ser Ala Leu Gly Ile Cys Thr Ser Thr Val Gly Met Lys Cys Thr Arg
                  95                 100                 105

 tta gga ggg gac aga gaa acc aag agc cat gct tcc ttt gct gga gga      748
 Leu Gly Gly Asp Arg Glu Thr Lys Ser His Ala Ser Phe Ala Gly Gly
             110                 115                 120

 gtc tgt ttc atg tct gca gga atc tct agt tta atc tcg aca gtg tgg      796
 Val Cys Phe Met Ser Ala Gly Ile Ser Ser Leu Ile Ser Thr Val Trp
         125                 130                 135

 tac aca aag gag atc ata gca aac ttt ctg gat ctg aca gtt cca gaa      844
 Tyr Thr Lys Glu Ile Ile Ala Asn Phe Leu Asp Leu Thr Val Pro Glu
     140                 145                 150

 agc aac aaa cat gaa cct gga gga gct atc tct ggt ttg ggg aca aaa      892
 Ser Asn Lys His Glu Pro Gly Gly Ala Ile Ser Gly Leu Gly Thr Lys
 155                 160                 165                 170

 gct tgt cct gga atc gta aag atg tgt cga aca ttg cag agg tac tga      940
 Ala Cys Pro Gly Ile Val Lys Met Cys Arg Thr Leu Gln Arg Tyr 
                 175                 180                 185

 gccataacag agaggcgact acgctgtttg cttcctgtat tggctgcaag tctcctggag   1000

 ggtttacttt ctagagtgaa cccagaacac ttctgccatg ggaatgcagg catagcagac   1060

 ttcactctgc cacttccttt tgaaaagtca aagtcatctg agttctgtaa tccaggaata   1120

 aatcgagtgt ccttttcaac caccagaagt tcagcgacgt cggcattaag aatagatctt   1180

 gtgattcccc ctggcccagg gcccacttcg taaacataag catttgtcag attgccagct   1240

 ttccttacaa tcttatttca cgtgtctcct gggcggtggg accggagttc ttctgataca   1300

 aagaggtcga aggacctgac caaaagcccg tcgcacgcca gtgcctggac acccgcccgc   1360

 ggggacgtgc aagacccccc ggcccacgcc cccacggaca ctggggagac atccggggag   1420

 cactgctaag ccatccacct gtcagcctca agtccaggag gaaattctgt gatagctgct   1480

 tcgctgcttg cagtcttaac aacttaatga tttctcgaat cgtgggcaac ggagggagac   1540

 ggcaagtgct gagttttccg gaggcagcca tgatacgcgg caagcact                1588




      <210> 509
      <211> 1007
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (552)..(995)

      <400> 509
 tcagcggttc gcgccgccga gcgcccattg gccagcggaa cgcgtcgcgt cacaatggag     60

 ccggtcggag gcggcgagcc ggacagcgcc ggggcttccc gctgagcccg cagcctccgg    120

 cagccgggaa agtgcgggcg cggggccgca gcctgcccgc ccggagcggc ccaggagcac    180

 gccgcgggga gcgcgggcgt ccggggctgg agtcgcgcag aatcctcaga gtgaaaacac    240

 caacaggcgt ccagattcgt gtgtattcag catggctact agaccgtcac tacctggatg    300

 gcccacaggt aatagttaac ctcttctggt gagaagtcag aaggtgatct ctttaatgct    360

 ttctttgtta agaatttttc aaattgagac taagttgcag aggttccagt ggaccagcat    420

 tcatagaatg aagacaaaca cagagatggt gtgtctaaga aacttcaaaa ggtgtagacc    480

 tcctgactga agcatattgg atttatttaa tttttttcac gtgtatttct gtcctcctac    540

 aagggaaagt c atg att aca cta act gag cta aaa tgc tta gca gat gcc     590
              Met Ile Thr Leu Thr Glu Leu Lys Cys Leu Ala Asp Ala
                1               5                  10

 cag tca tct tat cac atc tta aaa cca tgg tgg gac gtc ttc tgg tat      638
 Gln Ser Ser Tyr His Ile Leu Lys Pro Trp Trp Asp Val Phe Trp Tyr
      15                  20                  25

 tac atc aca ctg atc atg ctg ctg gtg gcc gtg ctg gcc gga gct ctc      686
 Tyr Ile Thr Leu Ile Met Leu Leu Val Ala Val Leu Ala Gly Ala Leu
  30                  35                  40                  45

 cag ctg acg cag agc agg gtt ctg tgc tgt ctt cca tgc aaa gtg gaa      734
 Gln Leu Thr Gln Ser Arg Val Leu Cys Cys Leu Pro Cys Lys Val Glu
                  50                  55                  60

 ttt gac aat cac tgt gcc gtg cct tgg gac atc ctg aaa gcc agc atg      782
 Phe Asp Asn His Cys Ala Val Pro Trp Asp Ile Leu Lys Ala Ser Met
              65                  70                  75

 aac aca tcc tct aat cct ggg aca ccg ctt ccg ctc ccc ctc cga att      830
 Asn Thr Ser Ser Asn Pro Gly Thr Pro Leu Pro Leu Pro Leu Arg Ile
          80                  85                  90

 cag aat gac ctc cac cga cag cag tac tcc tat att gat gcc gtc tgt      878
 Gln Asn Asp Leu His Arg Gln Gln Tyr Ser Tyr Ile Asp Ala Val Cys
      95                 100                 105

 tac gag aaa cag ctc cat tgg ttt gca aag ttt ttc ccc tat ctg gtg      926
 Tyr Glu Lys Gln Leu His Trp Phe Ala Lys Phe Phe Pro Tyr Leu Val
 110                 115                 120                 125

 gct ctt gca cac gct cat ctg tgc aac ctg cag caa ctt tgg gct tca      974
 Ala Leu Ala His Ala His Leu Cys Asn Leu Gln Gln Leu Trp Ala Ser
                 130                 135                 140

 cta ccc cag tac cag tcc tag ctcgagcatt tt                           1007
 Leu Pro Gln Tyr Gln Ser 
             145





      <210> 510
      <211> 1188
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (1)..(1188)

      <400> 510
  atg gcc ggg tct cct agc cgc gcc gcg ggc cgg cga ctg cag ctt ccc      48
  Met Ala Gly Ser Pro Ser Arg Ala Ala Gly Arg Arg Leu Gln Leu Pro
    1               5                  10                  15

 ctg ctg tgc ctc ttc ctc cag ggc gcc act gcc gtc ctc ttt gct gtc       96
 Leu Leu Cys Leu Phe Leu Gln Gly Ala Thr Ala Val Leu Phe Ala Val
              20                  25                  30

 ttt gtc cgc tac aac cac aaa acc gac gct gcc ctc tgg cac cgg agc      144
 Phe Val Arg Tyr Asn His Lys Thr Asp Ala Ala Leu Trp His Arg Ser
          35                  40                  45

 aac cac agt aac gcg gac aat gaa ttt tac ttt cgc tac cca agc ttc      192
 Asn His Ser Asn Ala Asp Asn Glu Phe Tyr Phe Arg Tyr Pro Ser Phe
      50                  55                  60

 cag gac gtg cat gcc atg gtc ttc gtg ggc ttt gac ttc ctc atg gtc      240
 Gln Asp Val His Ala Met Val Phe Val Gly Phe Asp Phe Leu Met Val
  65                  70                  75                  80

 ttc ctg cag cgt tac ggc ttc agc agc gtg ggc ttc acc ttc ctc ctg      288
 Phe Leu Gln Arg Tyr Gly Phe Ser Ser Val Gly Phe Thr Phe Leu Leu
                  85                  90                  95

 gcc gcc ttt gcc ctg cag tgg tcc aca ctg gtc cag ggc ttt ctc cac      336
 Ala Ala Phe Ala Leu Gln Trp Ser Thr Leu Val Gln Gly Phe Leu His
             100                 105                 110

 tcc ttc cac ggt ggc cac atc cat gtt ggc gtg gag agc atg atc aat      384
 Ser Phe His Gly Gly His Ile His Val Gly Val Glu Ser Met Ile Asn
         115                 120                 125

 gct gac ttt tgt gcg ggg gcc gtg ctc atc tcc ttt ggt gcc gtc ctg      432
 Ala Asp Phe Cys Ala Gly Ala Val Leu Ile Ser Phe Gly Ala Val Leu
     130                 135                 140

 ggc aag acc ggg cct acc cag ctg ctg ctc atg gcc ctg ctg gag gtg      480
 Gly Lys Thr Gly Pro Thr Gln Leu Leu Leu Met Ala Leu Leu Glu Val
 145                 150                 155                 160

 gtg ctg ttt ggc atc aat gag ttt gtg ctc ctt cat ctc ctg ggg gtg      528
 Val Leu Phe Gly Ile Asn Glu Phe Val Leu Leu His Leu Leu Gly Val
                 165                 170                 175

 aga gat gcc gga ggc tcc atg act atc cac acc ttt ggt gcc tac ttc      576
 Arg Asp Ala Gly Gly Ser Met Thr Ile His Thr Phe Gly Ala Tyr Phe
             180                 185                 190

 ggg ctc gtc ctt tcg cgg gtt ctg tac agg ccc cag ctg gag aag agc      624
 Gly Leu Val Leu Ser Arg Val Leu Tyr Arg Pro Gln Leu Glu Lys Ser
         195                 200                 205

 aag cac cgc cag ggc tcc gtc tac cat tca gac ctc ttc gcc atg att      672
 Lys His Arg Gln Gly Ser Val Tyr His Ser Asp Leu Phe Ala Met Ile
     210                 215                 220

 ggg acc atc ttc ctg tgg atc ttc tgg cct agc ttc aat gct gca ctc      720
 Gly Thr Ile Phe Leu Trp Ile Phe Trp Pro Ser Phe Asn Ala Ala Leu
 225                 230                 235                 240

 aca gcg ctg ggg gct ggg cag cat cgg acg gcc ctc aac aca tac tac      768
 Thr Ala Leu Gly Ala Gly Gln His Arg Thr Ala Leu Asn Thr Tyr Tyr
                 245                 250                 255

 tcc ctg gct gcc agc acc ctt ggc acc ttt gcc ttg tca gcc ctt gta      816
 Ser Leu Ala Ala Ser Thr Leu Gly Thr Phe Ala Leu Ser Ala Leu Val
             260                 265                 270

 ggg gaa gat ggg agg ctt gac atg ccc atc ctt gaa tca aaa ttc aaa      864
 Gly Glu Asp Gly Arg Leu Asp Met Pro Ile Leu Glu Ser Lys Phe Lys
         275                 280                 285

 gtc caa gac aca tgt gga gtc cac aac ctc cat ggg atg ccg ggg gtc      912
 Val Gln Asp Thr Cys Gly Val His Asn Leu His Gly Met Pro Gly Val
     290                 295                 300

 ctg ggg gcc ctc ctg ggg gtc ctt gtg gct gga ctt gcc acc cat gaa      960
 Leu Gly Ala Leu Leu Gly Val Leu Val Ala Gly Leu Ala Thr His Glu
 305                 310                 315                 320

 gct tac gga gat ggc ctg gag agt gtg ttt cca ctc ata gcc gag ggc     1008
 Ala Tyr Gly Asp Gly Leu Glu Ser Val Phe Pro Leu Ile Ala Glu Gly
                 325                 330                 335

 cag cgc agt gcc acg tca cag gcc atg cac cag ctc ttc ggg ctg ttt     1056
 Gln Arg Ser Ala Thr Ser Gln Ala Met His Gln Leu Phe Gly Leu Phe
             340                 345                 350

 gtc aca ctg atg ttt gcc tct gtg ggc ggg ggc ctt gga ggg ctc ctg     1104
 Val Thr Leu Met Phe Ala Ser Val Gly Gly Gly Leu Gly Gly Leu Leu
         355                 360                 365

 ctg aag cta ccc ttt ctg gac tcc ccc ccc aga ctc cca gca cta cga     1152
 Leu Lys Leu Pro Phe Leu Asp Ser Pro Pro Arg Leu Pro Ala Leu Arg
     370                 375                 380

 gga cca agt tca ctg gca ggt gcc tgg cga gca tga                     1188
 Gly Pro Ser Ser Leu Ala Gly Ala Trp Arg Ala 
 385                 390                 395





      <210> 511
      <211> 720
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (1)..(720)

      <400> 511
  atg gct tcc ctg ttt cat cag ctt cag atc ctg gtc tgg aaa aat tgg      48
  Met Ala Ser Leu Phe His Gln Leu Gln Ile Leu Val Trp Lys Asn Trp
    1               5                  10                  15

 cta ggt gta aaa agg cag ccg ctt tgg aca ctt gtc ttg atc tta tgg       96
 Leu Gly Val Lys Arg Gln Pro Leu Trp Thr Leu Val Leu Ile Leu Trp
              20                  25                  30

 cca gtc att att ttc ata att ttg gct att act cgg acc aaa ttt cct      144
 Pro Val Ile Ile Phe Ile Ile Leu Ala Ile Thr Arg Thr Lys Phe Pro
          35                  40                  45

 cca act gca aaa cca act tgt tac ctc gca cct cga aac ctt cct agt      192
 Pro Thr Ala Lys Pro Thr Cys Tyr Leu Ala Pro Arg Asn Leu Pro Ser
      50                  55                  60

 act gga ttc ttt cca ttc ctg cag acc cta ctc tgt gac aca gac tct      240
 Thr Gly Phe Phe Pro Phe Leu Gln Thr Leu Leu Cys Asp Thr Asp Ser
  65                  70                  75                  80

 aaa tgc aaa gac aca ccc tat ggc cca caa gat ctg ctt cgt agg aaa      288
 Lys Cys Lys Asp Thr Pro Tyr Gly Pro Gln Asp Leu Leu Arg Arg Lys
                  85                  90                  95

 gga att gat gat gca cta ttt aaa gac agt gag att ctg aga aag tca      336
 Gly Ile Asp Asp Ala Leu Phe Lys Asp Ser Glu Ile Leu Arg Lys Ser
             100                 105                 110

 tcc aac ctg gat aag gac agc agt tta tca ttc cag agc acc caa gtt      384
 Ser Asn Leu Asp Lys Asp Ser Ser Leu Ser Phe Gln Ser Thr Gln Val
         115                 120                 125

 cca gaa aga agg cat gca tca cta gcc aca gta ttt ccc agt cca agt      432
 Pro Glu Arg Arg His Ala Ser Leu Ala Thr Val Phe Pro Ser Pro Ser
     130                 135                 140

 tct gat ttg gaa atc ccc gga aca tat act ttc aat ggc agt caa gtg      480
 Ser Asp Leu Glu Ile Pro Gly Thr Tyr Thr Phe Asn Gly Ser Gln Val
 145                 150                 155                 160

 ctc gca cga att ctt ggc ttg gaa aag ctg tta aag caa aat tca act      528
 Leu Ala Arg Ile Leu Gly Leu Glu Lys Leu Leu Lys Gln Asn Ser Thr
                 165                 170                 175

 tca gaa gat ata cga aga gaa cta tgt gac agc tat tca gga tac att      576
 Ser Glu Asp Ile Arg Arg Glu Leu Cys Asp Ser Tyr Ser Gly Tyr Ile
             180                 185                 190

 gtg gat gat gcc ttc tct tgg acc ttt cta gga aga aat gtt ttt aac      624
 Val Asp Asp Ala Phe Ser Trp Thr Phe Leu Gly Arg Asn Val Phe Asn
         195                 200                 205

 aaa ttt tgc ctt tct aac atg acc ctt tta gag tct tct ctc caa gaa      672
 Lys Phe Cys Leu Ser Asn Met Thr Leu Leu Glu Ser Ser Leu Gln Glu
     210                 215                 220

 cta aac aaa cag ttc tcc cag aca gag gag ctg cag tac cag agg tga      720
 Leu Asn Lys Gln Phe Ser Gln Thr Glu Glu Leu Gln Tyr Gln Arg 
 225                 230                 235





      <210> 512
      <211> 870
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (47)..(547)

      <220>
      <221> misc_feature
      <222> (1)...(870)
      <223> n = a,t,c or g

      <400> 512
 gcaaagcgac ccctgccctc catcctgact gctcctccta agagag   atg gca ccg      55
                                                      Met Ala Pro
                                                        1

 gcc aga gca gga ttc tgc ccc ctt ctg ctg ctt ctg ctg ctg ggg ctg      103
 Ala Arg Ala Gly Phe Cys Pro Leu Leu Leu Leu Leu Leu Leu Gly Leu
       5                  10                  15

 tgg gtg gca gag atc cca gtc agt gcc aag ccc aag ggc atg acc tca      151
 Trp Val Ala Glu Ile Pro Val Ser Ala Lys Pro Lys Gly Met Thr Ser
  20                  25                  30                  35

 tca cag tgg ttt aaa att cag cac atg cag ccc agc cct caa gca tgc      199
 Ser Gln Trp Phe Lys Ile Gln His Met Gln Pro Ser Pro Gln Ala Cys
                  40                  45                  50

 aac tca gcc atg aaa aac att aac aag cac aca aaa cgg tgc aaa gac      247
 Asn Ser Ala Met Lys Asn Ile Asn Lys His Thr Lys Arg Cys Lys Asp
              55                  60                  65

 ctc aac acc ttc ctg cac gag cct ttc tcc agt gtg gcc gcc acc tgc      295
 Leu Asn Thr Phe Leu His Glu Pro Phe Ser Ser Val Ala Ala Thr Cys
          70                  75                  80

 cag acc ccc aaa ata gcc tgc aag aat ggc gat aaa aac tgc cac cag      343
 Gln Thr Pro Lys Ile Ala Cys Lys Asn Gly Asp Lys Asn Cys His Gln
      85                  90                  95

 agc cac ggg gcc gtg tcc ctg acc atg tgt aag ctc acc tca ggg aag      391
 Ser His Gly Ala Val Ser Leu Thr Met Cys Lys Leu Thr Ser Gly Lys
 100                 105                 110                 115

 tat ccg aac tgc agg tac aaa gag aag cga cag aac aag tct tac gta      439
 Tyr Pro Asn Cys Arg Tyr Lys Glu Lys Arg Gln Asn Lys Ser Tyr Val
                 120                 125                 130

 gtg gcc ttg tac ctt cta ctc tac cag ttg cgc aag aaa gaa gtc act      487
 Val Ala Leu Tyr Leu Leu Leu Tyr Gln Leu Arg Lys Lys Glu Val Thr
             135                 140                 145

 gtt aca gag gca agc ggt gaa cta ggt aag agt tca ctc atg aag aaa      535
 Val Thr Glu Ala Ser Gly Glu Leu Gly Lys Ser Ser Leu Met Lys Lys
         150                 155                 160

 cga gtg ctc tga aga gccagttacc ctgtgttggc tgcaataaag gtcattacct      590
 Arg Val Leu 
     165

 ctctagccaa gagattgttt atgaggtgct ctggcatttt attccttctc tctcttcctc    650

 tctaactgcc cctcccgttt ctctagacca ctgctcttcc aacctaggcc ctggacctgg    710

 ctctggccag atccccttgg cctgaagaca taaggtanag ggagtgtctg agcttcatcc    770

 cccagatcca ggatcacatt tcctttgacc ttaagggact tcgtggccct gagcctgctt    830

 gcacaaacca ggctgtggag ctgcagagct tctttctctg                          870




      <210> 513
      <211> 2462
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (45)..(2339)

      <400> 513
 cccggctaga atctgaagtg cgggagagtg ctggaccctg agtg atg ggg ccg gcg      56
                                                  Met Gly Pro Ala
                                                    1

 cca gct gga gag cag ctt cgc gga gcg act gga gag cca gag gtg atg      104
 Pro Ala Gly Glu Gln Leu Arg Gly Ala Thr Gly Glu Pro Glu Val Met
   5                  10                  15                  20

 gaa cca gcc ctg gaa ggc aca ggc aaa gag ggg aag aaa gca tcc tcc      152
 Glu Pro Ala Leu Glu Gly Thr Gly Lys Glu Gly Lys Lys Ala Ser Ser
                  25                  30                  35

 agg aag cgt aca ttg gct gaa cct cca gcg aag ggc ctc ctg cag cca      200
 Arg Lys Arg Thr Leu Ala Glu Pro Pro Ala Lys Gly Leu Leu Gln Pro
              40                  45                  50

 gtg aag ctc agc agg gca gaa ctg tac aag gag cct acc aat gag gag      248
 Val Lys Leu Ser Arg Ala Glu Leu Tyr Lys Glu Pro Thr Asn Glu Glu
          55                  60                  65

 ctt aat cgc ctt cgg gag act gag atc ttg ttc cac tcc agc ttg ctt      296
 Leu Asn Arg Leu Arg Glu Thr Glu Ile Leu Phe His Ser Ser Leu Leu
      70                  75                  80

 cgt tta cag gta gag gag cta cta aag gaa gta agg ctg tca gag aag      344
 Arg Leu Gln Val Glu Glu Leu Leu Lys Glu Val Arg Leu Ser Glu Lys
  85                  90                  95                 100

 aag aag gat cgg att gat gcc ttc cta cgg gag gtc aac cag cgg gtt      392
 Lys Lys Asp Arg Ile Asp Ala Phe Leu Arg Glu Val Asn Gln Arg Val
                 105                 110                 115

 gtg agg gtg ccc tca gtc cct gag aca gag ctc act gac cag gca tgg      440
 Val Arg Val Pro Ser Val Pro Glu Thr Glu Leu Thr Asp Gln Ala Trp
             120                 125                 130

 ctc cca gct ggg gtt cga gtg ccc ctc cac caa gtg ccc tat gcc gtg      488
 Leu Pro Ala Gly Val Arg Val Pro Leu His Gln Val Pro Tyr Ala Val
         135                 140                 145

 aag ggc tgt ttc cgc ttc ctg ccc cca gcc cag gtt act gtt gtg ggc      536
 Lys Gly Cys Phe Arg Phe Leu Pro Pro Ala Gln Val Thr Val Val Gly
     150                 155                 160

 agc tac ctt ctg ggc acc tgc atc cga cca gac atc aat gtg gat gtg      584
 Ser Tyr Leu Leu Gly Thr Cys Ile Arg Pro Asp Ile Asn Val Asp Val
 165                 170                 175                 180

 gca ctg acc atg ccc agg gaa atc cta cag gac aag gac ggg ctg aac      632
 Ala Leu Thr Met Pro Arg Glu Ile Leu Gln Asp Lys Asp Gly Leu Asn
                 185                 190                 195

 cag cgc tac ttc cgc aag cgt gcc ctc tac ctg gcc cac ttg gct cac      680
 Gln Arg Tyr Phe Arg Lys Arg Ala Leu Tyr Leu Ala His Leu Ala His
             200                 205                 210

 cac ctg gcc cag gac ccc ctc ttt ggc agt gtt tgc ttc tcc tac aca      728
 His Leu Ala Gln Asp Pro Leu Phe Gly Ser Val Cys Phe Ser Tyr Thr
         215                 220                 225

 aat ggc tgc cac ctg aaa ccc tca ctg ttg ctg cgg ccg cgt gga aag      776
 Asn Gly Cys His Leu Lys Pro Ser Leu Leu Leu Arg Pro Arg Gly Lys
     230                 235                 240

 gat gag cgc ctg gtc act gta cgt ctg cat ccg tgc cct cca cct gac      824
 Asp Glu Arg Leu Val Thr Val Arg Leu His Pro Cys Pro Pro Pro Asp
 245                 250                 255                 260

 ttc ttc cgc ccg tgc cgc ttg ctg cca acc aag aac aat gtg cgc tct      872
 Phe Phe Arg Pro Cys Arg Leu Leu Pro Thr Lys Asn Asn Val Arg Ser
                 265                 270                 275

 gcc tgg tac cga ggg cag agt cct gca ggg gat ggt agc cca gag cct      920
 Ala Trp Tyr Arg Gly Gln Ser Pro Ala Gly Asp Gly Ser Pro Glu Pro
             280                 285                 290

 cct acc ccc cgc tat aac aca tgg gtc ctg caa gat aca gtt ctc gag      968
 Pro Thr Pro Arg Tyr Asn Thr Trp Val Leu Gln Asp Thr Val Leu Glu
         295                 300                 305

 tcc cat ttg cag ctg ctg tca acc att ctg agt tca gcc cag ggc ctg     1016
 Ser His Leu Gln Leu Leu Ser Thr Ile Leu Ser Ser Ala Gln Gly Leu
     310                 315                 320

 aag gat ggc gtg gca ctt ctg aag gtc tgg ctg cgg cag cgg gag ctg     1064
 Lys Asp Gly Val Ala Leu Leu Lys Val Trp Leu Arg Gln Arg Glu Leu
 325                 330                 335                 340

 gac aag ggc cag ggt ggg ttt act ggg ttc ctt gtc tcc atg ctg gtt     1112
 Asp Lys Gly Gln Gly Gly Phe Thr Gly Phe Leu Val Ser Met Leu Val
                 345                 350                 355

 gtc ttc ctt gtg tct aca cgc aag atc cat acc acc atg agt ggc tac     1160
 Val Phe Leu Val Ser Thr Arg Lys Ile His Thr Thr Met Ser Gly Tyr
             360                 365                 370

 cag gtc ctg aga agt gtc ttg cag ttt ctg gcc act aca gac ctg aca     1208
 Gln Val Leu Arg Ser Val Leu Gln Phe Leu Ala Thr Thr Asp Leu Thr
         375                 380                 385

 gtc aac ggg atc agt tta tgt ctc agc tca gat ccc tct ttg ccg gcc     1256
 Val Asn Gly Ile Ser Leu Cys Leu Ser Ser Asp Pro Ser Leu Pro Ala
     390                 395                 400

 ctg gct gac ttc cac cag gcc ttc tcc gtt gtc ttc ctg gat tcc tca     1304
 Leu Ala Asp Phe His Gln Ala Phe Ser Val Val Phe Leu Asp Ser Ser
 405                 410                 415                 420

 ggc cat ctc aac ctc tgt gct gat gtc act gcc tct act tac cac cag     1352
 Gly His Leu Asn Leu Cys Ala Asp Val Thr Ala Ser Thr Tyr His Gln
                 425                 430                 435

 gta cag cat gag gca cgg ctg tct atg atg ttg ctg gac agc aga gct     1400
 Val Gln His Glu Ala Arg Leu Ser Met Met Leu Leu Asp Ser Arg Ala
             440                 445                 450

 gac gac ggg ttc cac ctg ctg ttg atg act ccc aaa ccc atg atc cgg     1448
 Asp Asp Gly Phe His Leu Leu Leu Met Thr Pro Lys Pro Met Ile Arg
         455                 460                 465

 gct ttt gac cat gtc ctg cat ctc cgt cca ctg agt cgc ctg cag gca     1496
 Ala Phe Asp His Val Leu His Leu Arg Pro Leu Ser Arg Leu Gln Ala
     470                 475                 480

 gcg tgc cac cgg ctg aag ctc tgg cca gag ctg cag gac aat ggt ggg     1544
 Ala Cys His Arg Leu Lys Leu Trp Pro Glu Leu Gln Asp Asn Gly Gly
 485                 490                 495                 500

 gac tat gtc tca gct gct ttg ggc ccc ctg acc acc ctc ctg gag cag     1592
 Asp Tyr Val Ser Ala Ala Leu Gly Pro Leu Thr Thr Leu Leu Glu Gln
                 505                 510                 515

 ggc ctg ggg gct cgg ctg aac ctg ctg gct cac tct cga ccc cca gtc     1640
 Gly Leu Gly Ala Arg Leu Asn Leu Leu Ala His Ser Arg Pro Pro Val
             520                 525                 530

 cca gag tgg gac atc agc caa gat cca cca aag cac aaa gac tct ggg     1688
 Pro Glu Trp Asp Ile Ser Gln Asp Pro Pro Lys His Lys Asp Ser Gly
         535                 540                 545

 acc ctg acc ctg gga ctc ctt ctc cgg cct gag gga ctg acc agc gtc     1736
 Thr Leu Thr Leu Gly Leu Leu Leu Arg Pro Glu Gly Leu Thr Ser Val
     550                 555                 560

 ctt gag ctg ggt cca gag gca gac cag cct gag gct gct aaa ttc cgc     1784
 Leu Glu Leu Gly Pro Glu Ala Asp Gln Pro Glu Ala Ala Lys Phe Arg
 565                 570                 575                 580

 cag ttc tgg gga tcc cgc tcg gag ctt cgg cgt ttc cag gac gga gcc     1832
 Gln Phe Trp Gly Ser Arg Ser Glu Leu Arg Arg Phe Gln Asp Gly Ala
                 585                 590                 595

 att cgg gaa gct gtg gtc tgg gag gca gcc tct atg tcc cag aag cgc     1880
 Ile Arg Glu Ala Val Val Trp Glu Ala Ala Ser Met Ser Gln Lys Arg
             600                 605                 610

 ctt att ccc cac cag gtg gtc acc cac ctc ttg gca ctc cat gct gac     1928
 Leu Ile Pro His Gln Val Val Thr His Leu Leu Ala Leu His Ala Asp
         615                 620                 625

 atc cca gaa acc tgt gtc cac tat gtg ggg ggc ccc ctg gat gca ctt     1976
 Ile Pro Glu Thr Cys Val His Tyr Val Gly Gly Pro Leu Asp Ala Leu
     630                 635                 640

 atc caa ggc ctg aaa gag acc tcc agc aca ggt gag gag gcc ctg gta     2024
 Ile Gln Gly Leu Lys Glu Thr Ser Ser Thr Gly Glu Glu Ala Leu Val
 645                 650                 655                 660

 gcg gcg gta cgt tgc tac gac gac ctc agt cgc cta ctg tgg ggg cta     2072
 Ala Ala Val Arg Cys Tyr Asp Asp Leu Ser Arg Leu Leu Trp Gly Leu
                 665                 670                 675

 gag ggt ctc cca ctg acc gtg tct gct gtt cag gga gct cac cca gtg     2120
 Glu Gly Leu Pro Leu Thr Val Ser Ala Val Gln Gly Ala His Pro Val
             680                 685                 690

 ctg cgc tac aca gag gtg ttc cca cca act cca gtc cgt cca gcc ttc     2168
 Leu Arg Tyr Thr Glu Val Phe Pro Pro Thr Pro Val Arg Pro Ala Phe
         695                 700                 705

 tcc ttc tat gag act ctg cgg gag cgg tcc tca ctg ctg ccc ggc tcg     2216
 Ser Phe Tyr Glu Thr Leu Arg Glu Arg Ser Ser Leu Leu Pro Gly Ser
     710                 715                 720

 ata agc ctg tcc ggc tac gtg gag ccc atg aac gtg gtt tgt cac ctg     2264
 Ile Ser Leu Ser Gly Tyr Val Glu Pro Met Asn Val Val Cys His Leu
 725                 730                 735                 740

 gag ggc agt ggg cag tgg caa cag gaa gct gag gcg tgg agg ggt cga     2312
 Glu Gly Ser Gly Gln Trp Gln Gln Glu Ala Glu Ala Trp Arg Gly Arg
                 745                 750                 755

 gtg cct cag tgc gcc tgg aaa gtg tga caaac agatggctgg agcgtgcatg     2364
 Val Pro Gln Cys Ala Trp Lys Val 
             760

 ccagccagga gctaggaggt atgttcggcc ggggtacagg accaaatgag ggggacccac   2424

 ggtcaccaag aaacctcgct gaaaaaggaa tgaaccca                           2462




      <210> 514
      <211> 603
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (1)..(603)

      <400> 514
  atg ggg cat gcc ggc ctt ggg ctg gcc atg gaa gca gag agg agt gag      48
  Met Gly His Ala Gly Leu Gly Leu Ala Met Glu Ala Glu Arg Ser Glu
    1               5                  10                  15

 atg tgg aaa gga gag agg aag aat ttt cag ggg ggt gaa gac atg ggg       96
 Met Trp Lys Gly Glu Arg Lys Asn Phe Gln Gly Gly Glu Asp Met Gly
              20                  25                  30

 aca tgc tgg gtg cgg agc ccc gtg gtg cac agt gtc ctg gtc atg ggc      144
 Thr Cys Trp Val Arg Ser Pro Val Val His Ser Val Leu Val Met Gly
          35                  40                  45

 tac ggc ggc ctc acg tcc ctc ttc aac ctg gtg gtg ctg gcc tgg gcg      192
 Tyr Gly Gly Leu Thr Ser Leu Phe Asn Leu Val Val Leu Ala Trp Ala
      50                  55                  60

 ctg tgg acc ctg cgc agg ctg cgg gag cgg gcg gat gca cca agt gtc      240
 Leu Trp Thr Leu Arg Arg Leu Arg Glu Arg Ala Asp Ala Pro Ser Val
  65                  70                  75                  80

 agg gcc tgc cat gac act gtc act gtg ctg ggc ctc acc gtg ctg ctg      288
 Arg Ala Cys His Asp Thr Val Thr Val Leu Gly Leu Thr Val Leu Leu
                  85                  90                  95

 gga acc acc tgg gcc ttg gcc ttc ttt tct ttt ggc gtc ttc ctg ctg      336
 Gly Thr Thr Trp Ala Leu Ala Phe Phe Ser Phe Gly Val Phe Leu Leu
             100                 105                 110

 ccc cag ctg ttc ctc ttc acc atc tta aac tcg ctc tac ggc aaa gga      384
 Pro Gln Leu Phe Leu Phe Thr Ile Leu Asn Ser Leu Tyr Gly Lys Gly
         115                 120                 125

 ggg ggc act gtt tct aag aag agt gat gat acc acc gta ttt ttg aaa      432
 Gly Gly Thr Val Ser Lys Lys Ser Asp Asp Thr Thr Val Phe Leu Lys
     130                 135                 140

 aat gat gaa aca gcg tgg ggg aaa ctg cta tgt ctt cca tat tca ggc      480
 Asn Asp Glu Thr Ala Trp Gly Lys Leu Leu Cys Leu Pro Tyr Ser Gly
 145                 150                 155                 160

 ttt ttc ttc tcc aag ccc att tcc tcc cta gca atg ata aga gga aac      528
 Phe Phe Phe Ser Lys Pro Ile Ser Ser Leu Ala Met Ile Arg Gly Asn
                 165                 170                 175

 act ccc gcg ctt gtg ggt ggt tat gac atc ctt gcc atc tat gag gtg      576
 Thr Pro Ala Leu Val Gly Gly Tyr Asp Ile Leu Ala Ile Tyr Glu Val
             180                 185                 190

 gag cat ttc caa caa gag cag gtc tga                                  603
 Glu His Phe Gln Gln Glu Gln Val 
         195                 200





      <210> 515
      <211> 4042
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (924)..(3314)

      <400> 515
 gatttccatc caggaaaagt cttcaggtgt tgtccaagat cttggccatc gaaaagtcag     60

 gagatttaaa caaaatagct ttggagtggg tggccatcat gcatggcctg ggtgccctgc    120

 tggaggtgtg gctgactttc cagcagaagt ggatttttct gaataaagtt ctgcatgaga    180

 tgaagatcca gtttcctaat gctgacctga actctcgttt caaggtcatg gatgaccagt    240

 atcgaaccct gatgcgcatc tctgtagctg accccatggt tctgtcactt gtagtgccca    300

 gtgccgagag gagcccttac ttccaaggcc agcagctgca acaactgctg caagcaggat    360

 cggtggagct ggagggcatc atcatgagtc tggagagcgt gctctatggg gtgtgtgctc    420

 acttcccccg cctcttcttc cttagtgaca gtgagctggt agccctgctg gctgctcgac    480

 tggaatcatg cgaagcccag ctatgggtac gacgctgctt tcctcatgtg catgctgtga    540

 gcttcaggtc ttgcccaact ggtgagaaaa acacagatga ctgggagtca agcccaaaca    600

 cacagactca ggtggaggca cttgcagtgc taggggcagg tggggaggag gtgaagctgc    660

 agggtcccct tcctctgcat ccagatctcc ctaagtggct ggcctctctg gagaagtgtc    720

 tgcgcttggc actggtgcac atgctgcagg gctgtgtggc tgctcgcctt gctcgaggcc    780

 catctctagg tgaggccctc aagcaactgc ccaagcaaaa caagttgtac ctgcaactgt    840

 atgtccagca ctggatcgac ttagtccagg ccttcccatg gcagtgtgtg ctggtggcag    900

 aggaggtggt atggcgggcc gag    atg gag gcg gct ctg ctt gag tgg ggt     950
                              Met Glu Ala Ala Leu Leu Glu Trp Gly
                                1               5

 acc ctg gcc atg gtc tcc atg cat atg cgc aag ctt gag gta ctg gtg      998
 Thr Leu Ala Met Val Ser Met His Met Arg Lys Leu Glu Val Leu Val
  10                  15                  20                  25

 aat ttt atg cgg gcc cag agg gct tcc caa ggt ggg cag tcc ctg cct     1046
 Asn Phe Met Arg Ala Gln Arg Ala Ser Gln Gly Gly Gln Ser Leu Pro
                  30                  35                  40

 tct gtc cgc cag acc agc ctt ctc agt gcc ctg ctg gtc atg gca gtg     1094
 Ser Val Arg Gln Thr Ser Leu Leu Ser Ala Leu Leu Val Met Ala Val
              45                  50                  55

 act cac cgg gat ata gca cag ctg ctg gaa cag cac cag gtc agt gat     1142
 Thr His Arg Asp Ile Ala Gln Leu Leu Glu Gln His Gln Val Ser Asp
          60                  65                  70

 ctc aca gac ttt cac tgg gtc cgc caa ctc aag tat cac ttg ggt tca     1190
 Leu Thr Asp Phe His Trp Val Arg Gln Leu Lys Tyr His Leu Gly Ser
      75                  80                  85

 cct cac ata atc ccc aaa agc ccc cta cag agt ctt aag act att gca     1238
 Pro His Ile Ile Pro Lys Ser Pro Leu Gln Ser Leu Lys Thr Ile Ala
  90                  95                 100                 105

 tct tct gaa ccc tct ctg tca cca gcg gca tgc tgg ata gat gtg cta     1286
 Ser Ser Glu Pro Ser Leu Ser Pro Ala Ala Cys Trp Ile Asp Val Leu
                 110                 115                 120

 ggc agg tcc ttc ctg tac aat tac gag tat ctg gga cct aga cta ggg     1334
 Gly Arg Ser Phe Leu Tyr Asn Tyr Glu Tyr Leu Gly Pro Arg Leu Gly
             125                 130                 135

 cct cta ccc agc cta ctg cct gaa cgg cca gcc ctg gta cta tta ttg     1382
 Pro Leu Pro Ser Leu Leu Pro Glu Arg Pro Ala Leu Val Leu Leu Leu
         140                 145                 150

 gcc cta gag gag gtg gcc tgt ggg acc gta ctg ggt cct aat ggt gtg     1430
 Ala Leu Glu Glu Val Ala Cys Gly Thr Val Leu Gly Pro Asn Gly Val
     155                 160                 165

 ggc aag aga gct ata gtg aac agc ctg gca cag gcc ctg ggc cgc cag     1478
 Gly Lys Arg Ala Ile Val Asn Ser Leu Ala Gln Ala Leu Gly Arg Gln
 170                 175                 180                 185

 ctg gtg atg cta ccc tgc tca cct cag ata gag gct caa tgc ctg agc     1526
 Leu Val Met Leu Pro Cys Ser Pro Gln Ile Glu Ala Gln Cys Leu Ser
                 190                 195                 200

 aac tat ctg aat ggt gcc ctg cag ggt ggt gcc tgg ctg ctg ttg gag     1574
 Asn Tyr Leu Asn Gly Ala Leu Gln Gly Gly Ala Trp Leu Leu Leu Glu
             205                 210                 215

 aaa gtt cat cag ctg ccc cct ggc ttg ctc tct gcc ctg ggc cag cgc     1622
 Lys Val His Gln Leu Pro Pro Gly Leu Leu Ser Ala Leu Gly Gln Arg
         220                 225                 230

 ctg ggt gaa ctg cac cac ttg tat gcc cca ctg tac cag gag gct tcc     1670
 Leu Gly Glu Leu His His Leu Tyr Ala Pro Leu Tyr Gln Glu Ala Ser
     235                 240                 245

 cga aac aca agc acc ata gac ccc acc cag ccc cag ctc ctt ggc agt     1718
 Arg Asn Thr Ser Thr Ile Asp Pro Thr Gln Pro Gln Leu Leu Gly Ser
 250                 255                 260                 265

 agc ttc ttt gaa aaa cat cat gtg tct gtg cgc ctt ggc tat ggc tgt     1766
 Ser Phe Phe Glu Lys His His Val Ser Val Arg Leu Gly Tyr Gly Cys
                 270                 275                 280

 ctc ctg gta ctg cgt gcc ctg agc tct gct gtg cct gcc aac ctg cac     1814
 Leu Leu Val Leu Arg Ala Leu Ser Ser Ala Val Pro Ala Asn Leu His
             285                 290                 295

 ctg ctg ctg cgg cct gtg gca ttg gca tta cct gat ctg cgg caa gtg     1862
 Leu Leu Leu Arg Pro Val Ala Leu Ala Leu Pro Asp Leu Arg Gln Val
         300                 305                 310

 gca gag ctg act ctg ctg ggt gca ggg atg agg gat gcc ttc cag atg     1910
 Ala Glu Leu Thr Leu Leu Gly Ala Gly Met Arg Asp Ala Phe Gln Met
     315                 320                 325

 gct acc cgc cta tcc aaa ttc ttc tct cta gag cgt gag ctg gtg tct     1958
 Ala Thr Arg Leu Ser Lys Phe Phe Ser Leu Glu Arg Glu Leu Val Ser
 330                 335                 340                 345

 ggg ccc ctg ccc tgc cgc ctg cca ctg ctc aag cag ata ctg gaa gac     2006
 Gly Pro Leu Pro Cys Arg Leu Pro Leu Leu Lys Gln Ile Leu Glu Asp
                 350                 355                 360

 aca ata cgg aca cta aat gtg acc aag gag gaa ccg aag tgc cag aag     2054
 Thr Ile Arg Thr Leu Asn Val Thr Lys Glu Glu Pro Lys Cys Gln Lys
             365                 370                 375

 cct cgc agc cta gct gcc att gag gag gct gcc cta ctg cat gcc cta     2102
 Pro Arg Ser Leu Ala Ala Ile Glu Glu Ala Ala Leu Leu His Ala Leu
         380                 385                 390

 ctg cgc tca cca ctg ttt agc att ctc aat ggg ctc cac ctg cac aac     2150
 Leu Arg Ser Pro Leu Phe Ser Ile Leu Asn Gly Leu His Leu His Asn
     395                 400                 405

 ctc cga ggg ctg ttg tgt gcg ctt ttc cct agc gcc agc caa gtg ctg     2198
 Leu Arg Gly Leu Leu Cys Ala Leu Phe Pro Ser Ala Ser Gln Val Leu
 410                 415                 420                 425

 gca gaa cct atg act tac aag ctg atg aag cca ttg gtg gtg gag gaa     2246
 Ala Glu Pro Met Thr Tyr Lys Leu Met Lys Pro Leu Val Val Glu Glu
                 430                 435                 440

 ctg caa cag gta ggt ctg gat ccc agc cct gac att ttg ggg tcc ttg     2294
 Leu Gln Gln Val Gly Leu Asp Pro Ser Pro Asp Ile Leu Gly Ser Leu
             445                 450                 455

 gaa cag ttg agc cag gcc ctg agc cgg gcc tca ggc att ctg ctc ctg     2342
 Glu Gln Leu Ser Gln Ala Leu Ser Arg Ala Ser Gly Ile Leu Leu Leu
         460                 465                 470

 ggc cct gcg ggc agc ggc aag acc act tgt tgg cac agc tta ttt aag     2390
 Gly Pro Ala Gly Ser Gly Lys Thr Thr Cys Trp His Ser Leu Phe Lys
     475                 480                 485

 atc cag aat cgg ctg gca gcc atg gag gac acc tca acc caa ggc tgc     2438
 Ile Gln Asn Arg Leu Ala Ala Met Glu Asp Thr Ser Thr Gln Gly Cys
 490                 495                 500                 505

 cag cct gtg gaa att acc cac ctg tac ccc agt ggc ctc agc ccc cag     2486
 Gln Pro Val Glu Ile Thr His Leu Tyr Pro Ser Gly Leu Ser Pro Gln
                 510                 515                 520

 gag ttc ctg gga tgg cta gag ggc tcc tgc tgg cat cat ggc atc ttt     2534
 Glu Phe Leu Gly Trp Leu Glu Gly Ser Cys Trp His His Gly Ile Phe
             525                 530                 535

 ccc aag gta ctt cgt gca gcc ggt cag tgt aac aac atg ggc caa aag     2582
 Pro Lys Val Leu Arg Ala Ala Gly Gln Cys Asn Asn Met Gly Gln Lys
         540                 545                 550

 agg cag aca gag gaa tca atc ggg atc cag cac tgg ata ata tgt gat     2630
 Arg Gln Thr Glu Glu Ser Ile Gly Ile Gln His Trp Ile Ile Cys Asp
     555                 560                 565

 gga gcc tcc aat ggt gct tgg ctg gac tcc atc act tgc ctc ctg agt     2678
 Gly Ala Ser Asn Gly Ala Trp Leu Asp Ser Ile Thr Cys Leu Leu Ser
 570                 575                 580                 585

 gag ctt ccc cag ctt agt ctc ccc agt gga cag cag ata gca cga ccc     2726
 Glu Leu Pro Gln Leu Ser Leu Pro Ser Gly Gln Gln Ile Ala Arg Pro
                 590                 595                 600

 cca ggc acc ttt ctc ttg atg gag gtg gct gac aca aca ggc ata tcc     2774
 Pro Gly Thr Phe Leu Leu Met Glu Val Ala Asp Thr Thr Gly Ile Ser
             605                 610                 615

 ccc aca gtg gta ggc tgt tgt gcc cta gtc tgg tgt ggt gga gag cag     2822
 Pro Thr Val Val Gly Cys Cys Ala Leu Val Trp Cys Gly Gly Glu Gln
         620                 625                 630

 act tgg cag tgt ata ctt agt gcc ctg atg gca tcc ctt cct tat gag     2870
 Thr Trp Gln Cys Ile Leu Ser Ala Leu Met Ala Ser Leu Pro Tyr Glu
     635                 640                 645

 tac cgc ctg cag cac cgg aca gtc gct gag ctc aac cac atg gct gag     2918
 Tyr Arg Leu Gln His Arg Thr Val Ala Glu Leu Asn His Met Ala Glu
 650                 655                 660                 665

 gtt ctg gtg cct gca aca ttg cga ttc ctc acc tgc caa ggt gtc agc     2966
 Val Leu Val Pro Ala Thr Leu Arg Phe Leu Thr Cys Gln Gly Val Ser
                 670                 675                 680

 tct ctg ctg cag gta cac ggg cag cag gct gtt tgt gca ggt gtg gca     3014
 Ser Leu Leu Gln Val His Gly Gln Gln Ala Val Cys Ala Gly Val Ala
             685                 690                 695

 gaa gtt acc agc atg gca cgc atc ttg cat agt ctg ctt gac ctc cac     3062
 Glu Val Thr Ser Met Ala Arg Ile Leu His Ser Leu Leu Asp Leu His
         700                 705                 710

 ctt cgc cta aag gag gag aag gcc cct ggc cca gag gac ctc agc tat     3110
 Leu Arg Leu Lys Glu Glu Lys Ala Pro Gly Pro Glu Asp Leu Ser Tyr
     715                 720                 725

 agt gat cct gtg gcc caa agc ttc agg tct tca aaa agc agc ttt cta     3158
 Ser Asp Pro Val Ala Gln Ser Phe Arg Ser Ser Lys Ser Ser Phe Leu
 730                 735                 740                 745

 aac cgg tcc cag gtt gac agt gac gat gtg cca gat aag tgc agg gaa     3206
 Asn Arg Ser Gln Val Asp Ser Asp Asp Val Pro Asp Lys Cys Arg Glu
                 750                 755                 760

 cac ttg ctg gct gtc agc agt ttt ctt ttt gcc ttg atc tgg ggc ttt     3254
 His Leu Leu Ala Val Ser Ser Phe Leu Phe Ala Leu Ile Trp Gly Phe
             765                 770                 775

 gga gcc cac ctt ccc tcc agg tac cta cca gga tgg ggg atg gga gat     3302
 Gly Ala His Leu Pro Ser Arg Tyr Leu Pro Gly Trp Gly Met Gly Asp
         780                 785                 790

 gca gag ggc tga gat ggactggccc atggaagtaa aaacccacat gacatcactg     3357
 Ala Glu Gly 
     795

 ttagggtatg gtggagtgtg tgagtgtgtc ataaatggaa gtgttgtaac tgtctgacgc   3417

 ttttgcctgt gtgtccatct gagcaggttc tggcccatct ttgatacctt cataagggat   3477

 tctattagtc gcctctccaa ctaccctgag ccaccaccct cagccttggt gtttgatcta   3537

 catgtaagcc ctgaagatgg aacactggtc cccttcactg gccaatacct gagcagccac   3597

 atcaaaggaa ctttgggcac ctttcaccct tctatccaga ctgaacggct cttgtatgtg   3657

 gtggacctgc ttctgtcagg gggacagcca gtgttgctgg ctggagaggc agcaacaggg   3717

 aagtcagcct ttgtggaggt gctggtagag ccacatcacc cttacatata cagccccatc   3777

 caccctgcct tcagttcctc ccacctccgt ctcctgctga gcagaggaat ccagggccaa   3837

 acacaagcca gcccacagcc tgggcatcac caggattcta aaccctccct cctcttcttg   3897

 ctggaggacc tgcacctagc cacttctggt gaggagctgc gaagagggaa ggaaggagct   3957

 actgtcatct cttgagacta taaaatccct agcaatattc attgactctc aaatatatgt   4017

 ctgtagatct aaaaaaaaaa aaaaa                                         4042




      <210> 516
      <211> 2364
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (370)..(2067)

      <220>
      <221> misc_feature
      <222> (1)...(2364)
      <223> n = a,t,c or g

      <400> 516
 tcaccggtag atgagggtct catcttcgct gctgttgtac tggatttgga acatccacac     60

 ntgggtcgct ggctgccggg gaccccagtt caccagccct gaggtggcgg tcacctccgt    120

 cacctgcacg gctggctcag actccagcgt cccctcacca tggcccccgc gctcctgctg    180

 ctgctgctgg ccagtggagc ggccgcctgc ccgctgccct gcgtctgcca gaacctgtcc    240

 gagtcgctca gcaccctctg tgcccaccga ggcctgctgt ttgtgccgcc caacgtggac    300

 cggcgcacag tggagctgcg gctggctgac aacttcatcc aggccctggg gccccctgac    360

 ttccgcaac    atg acg gga ctg gtg gac ctg aca ctg tct cgc aat gcc     408
              Met Thr Gly Leu Val Asp Leu Thr Leu Ser Arg Asn Ala
                1               5                  10

 atc acc cgc att ggg gcc cgc gcc ttt ggg gac ctc gag agc ctg cgt      456
 Ile Thr Arg Ile Gly Ala Arg Ala Phe Gly Asp Leu Glu Ser Leu Arg
      15                  20                  25

 tcc ctc cac ctt gac ggc aac agg ctg gtg gag ctg ggc acc ggg agc      504
 Ser Leu His Leu Asp Gly Asn Arg Leu Val Glu Leu Gly Thr Gly Ser
  30                  35                  40                  45

 ctc cgg ggc ccc gtc aat ctg cag cac ctc atc ctc agc ggc aac cag      552
 Leu Arg Gly Pro Val Asn Leu Gln His Leu Ile Leu Ser Gly Asn Gln
                  50                  55                  60

 ctg ggc cgc atc gcg ccg gga gcc ttc gac gac ttc cta gag agc ctg      600
 Leu Gly Arg Ile Ala Pro Gly Ala Phe Asp Asp Phe Leu Glu Ser Leu
              65                  70                  75

 gag gac ctg gac ctg tcc tac aac aac ctc cgg cag gtg ccc tgg gcc      648
 Glu Asp Leu Asp Leu Ser Tyr Asn Asn Leu Arg Gln Val Pro Trp Ala
          80                  85                  90

 ggc atc ggc gcc atg cct gcc ctg cac acc ctc aac ctg gac cat aac      696
 Gly Ile Gly Ala Met Pro Ala Leu His Thr Leu Asn Leu Asp His Asn
      95                 100                 105

 ctt att gac gca ctg ccc cca ggc gcc ttc gcc cag ctc ggt cag ctc      744
 Leu Ile Asp Ala Leu Pro Pro Gly Ala Phe Ala Gln Leu Gly Gln Leu
 110                 115                 120                 125

 tcc cgc ctg gac ctc acc tcc aac cgc ctg gcc acg ctg gct ccg gac      792
 Ser Arg Leu Asp Leu Thr Ser Asn Arg Leu Ala Thr Leu Ala Pro Asp
                 130                 135                 140

 ccg ctt ttc tct cgt ggg cgt gat gca gag gcc tct ccc gcc ccc ctg      840
 Pro Leu Phe Ser Arg Gly Arg Asp Ala Glu Ala Ser Pro Ala Pro Leu
             145                 150                 155

 gtg ctg agc ttt agc ggg aac ccc ctg cac tgc aac tgt gag ctg ctg      888
 Val Leu Ser Phe Ser Gly Asn Pro Leu His Cys Asn Cys Glu Leu Leu
         160                 165                 170

 tgg ctg cgg cgg ctg gcg cgg ccg gac gac ctg gaa acg tgc gcc tcc      936
 Trp Leu Arg Arg Leu Ala Arg Pro Asp Asp Leu Glu Thr Cys Ala Ser
     175                 180                 185

 ccg ccc ggc ctg gcc ggc cgc tac ttc tgg gca gtg ccc gag ggc gag      984
 Pro Pro Gly Leu Ala Gly Arg Tyr Phe Trp Ala Val Pro Glu Gly Glu
 190                 195                 200                 205

 ttc tcc tgt gag ccg ccc ctc att gcc cgc cac acg cag cgc ctc tgg     1032
 Phe Ser Cys Glu Pro Pro Leu Ile Ala Arg His Thr Gln Arg Leu Trp
                 210                 215                 220

 gtg ctg gaa ggc cag cgg gcc acg ctg cgg tgc cgg gcc ctg ggt gac     1080
 Val Leu Glu Gly Gln Arg Ala Thr Leu Arg Cys Arg Ala Leu Gly Asp
             225                 230                 235

 ccc gcg cct acc atg cac tgg gtc ggt cct gac gac cgg ttg gtt ggc     1128
 Pro Ala Pro Thr Met His Trp Val Gly Pro Asp Asp Arg Leu Val Gly
         240                 245                 250

 aac tcc tcc cga gcc cgg gct ttc ccc aac ggg acc tta gag att ggg     1176
 Asn Ser Ser Arg Ala Arg Ala Phe Pro Asn Gly Thr Leu Glu Ile Gly
     255                 260                 265

 gtg acc ggc gct ggg gac gct ggg ggc tac acc tgc atc gcc acc aac     1224
 Val Thr Gly Ala Gly Asp Ala Gly Gly Tyr Thr Cys Ile Ala Thr Asn
 270                 275                 280                 285

 cct gct ggt gag gcc aca gcc cga gta gaa ctg cgg gtg ctg gcc ttg     1272
 Pro Ala Gly Glu Ala Thr Ala Arg Val Glu Leu Arg Val Leu Ala Leu
                 290                 295                 300

 ccc cat ggt ggg aac agc agt gcc gag ggg ggc cgc ccc ggg ccc tcg     1320
 Pro His Gly Gly Asn Ser Ser Ala Glu Gly Gly Arg Pro Gly Pro Ser
             305                 310                 315

 gac atc gcc gcc tcc gct cgc act gct gcc gag ggt gag ggg acg ctg     1368
 Asp Ile Ala Ala Ser Ala Arg Thr Ala Ala Glu Gly Glu Gly Thr Leu
         320                 325                 330

 gag tct gag cca gcc gtg cag gtg acg gag gtg acc gcc acc tca ggg     1416
 Glu Ser Glu Pro Ala Val Gln Val Thr Glu Val Thr Ala Thr Ser Gly
     335                 340                 345

 ctg gtg agc tgg ggt ccc ggg cgg cca gcc gac cca gtg tgg atg ttc     1464
 Leu Val Ser Trp Gly Pro Gly Arg Pro Ala Asp Pro Val Trp Met Phe
 350                 355                 360                 365

 caa atc cag tac aac agc agc gaa gat gag acc ctc atc tac cgg att     1512
 Gln Ile Gln Tyr Asn Ser Ser Glu Asp Glu Thr Leu Ile Tyr Arg Ile
                 370                 375                 380

 gtc cca gcc tcc agc cac cac ttc ctg ctg aag cac ctc gtc ccc ggc     1560
 Val Pro Ala Ser Ser His His Phe Leu Leu Lys His Leu Val Pro Gly
             385                 390                 395

 gct gac tat gac ctc tgc ctg ctg gcc ttg tca ccg gcc gct ggg ccc     1608
 Ala Asp Tyr Asp Leu Cys Leu Leu Ala Leu Ser Pro Ala Ala Gly Pro
         400                 405                 410

 tct gac ctc acg gcc acc agg ctg ctg ggc tgt gcc cat ttc tcc acg     1656
 Ser Asp Leu Thr Ala Thr Arg Leu Leu Gly Cys Ala His Phe Ser Thr
     415                 420                 425

 ctg ccg gcc tcg ccc ctg tgc cac gcc ctg cag gcc cac gtg ctg ggc     1704
 Leu Pro Ala Ser Pro Leu Cys His Ala Leu Gln Ala His Val Leu Gly
 430                 435                 440                 445

 ggg acc ctg acc gtg gcc gtg ggg ggt gtg ctg gtg gct gcc tta ctg     1752
 Gly Thr Leu Thr Val Ala Val Gly Gly Val Leu Val Ala Ala Leu Leu
                 450                 455                 460

 gtc ttc act gtg gcc ttg ctg gtt cgg ggc cgg ggg gcc gga aat ggc     1800
 Val Phe Thr Val Ala Leu Leu Val Arg Gly Arg Gly Ala Gly Asn Gly
             465                 470                 475

 cgc ctc ccc ctc aag ctc agc cac gtc cag tcc cag acc aat gga ggc     1848
 Arg Leu Pro Leu Lys Leu Ser His Val Gln Ser Gln Thr Asn Gly Gly
         480                 485                 490

 ccc agc ccc aca ccc aag gcc cac ccg ccg cgg agc ccc ccg ccc cgg     1896
 Pro Ser Pro Thr Pro Lys Ala His Pro Pro Arg Ser Pro Pro Pro Arg
     495                 500                 505

 ccg cag cgc agc tgc tct ctg gac ctg gga gat gcc ggg tgc tac ggt     1944
 Pro Gln Arg Ser Cys Ser Leu Asp Leu Gly Asp Ala Gly Cys Tyr Gly
 510                 515                 520                 525

 tat gcc agg cgc ctg gga gga gct tgg gcc cga cgg agc cac tct gtg     1992
 Tyr Ala Arg Arg Leu Gly Gly Ala Trp Ala Arg Arg Ser His Ser Val
                 530                 535                 540

 cat ggg ggg ctg ctc ggg gca ggg tgc cgg ggg gta gga ggc agc gcc     2040
 His Gly Gly Leu Leu Gly Ala Gly Cys Arg Gly Val Gly Gly Ser Ala
             545                 550                 555

 gag cgg ctg gaa gag agt gtg gtg tga tggac gggcagcttc ctgtgtgctc     2092
 Glu Arg Leu Glu Glu Ser Val Val 
         560                 565

 caagggatga gcctcgtggg gcagagggcc cggggccgcc gcctggcctg ggagtccctc   2152

 cctggttttt attctcagta cctcaggctc ccctgtgtac ttggaggggc agggagccct   2212

 ttcctcggtt ctggcctcca gaccagggta agggcaggcc cctccaacag gtgctcacag   2272

 ccaccgaggc aggggctgca gccacccact gggagtcttg tttttattta taataaaatt   2332

 gttggggaca cctcaaaaaa aaaaaaaaaa aa                                 2364




      <210> 517
      <211> 2127
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (151)..(2127)

      <400> 517
 atgctgtttt gactgaaaaa gaaaaaacaa gccaaacaaa atgcagagac agcctcagct     60

 gtagctacaa ggactcatac tgggaaggaa gataataata cagtagtttt agagccagac    120

 aagtgcaaca ttgctgtgga agaggaatat     atg act gat gag aaa aaa aag     171
                                      Met Thr Asp Glu Lys Lys Lys
                                        1               5

 aga aaa agt aat cag tta aag gag atc agg cgt aca gaa cta aag aga      219
 Arg Lys Ser Asn Gln Leu Lys Glu Ile Arg Arg Thr Glu Leu Lys Arg
          10                  15                  20

 tat tat agt att gta gag tta ctg atg gtc ctg tgc tgt cag cct cct      267
 Tyr Tyr Ser Ile Val Glu Leu Leu Met Val Leu Cys Cys Gln Pro Pro
      25                  30                  35

 gaa ccc cct tca gat gct ctt atg ata gaa ata gat gga gga gag agc      315
 Glu Pro Pro Ser Asp Ala Leu Met Ile Glu Ile Asp Gly Gly Glu Ser
  40                  45                  50                  55

 tgg tcg ttc atg gat ctg ttc tcc aat tct gac agg cag act aat gac      363
 Trp Ser Phe Met Asp Leu Phe Ser Asn Ser Asp Arg Gln Thr Asn Asp
                  60                  65                  70

 ccc cta aag atg tcc atg tcc tat ttc ccc aaa cct gtt agg tta cat      411
 Pro Leu Lys Met Ser Met Ser Tyr Phe Pro Lys Pro Val Arg Leu His
              75                  80                  85

 agc aaa gat gac aat caa aac aaa aca cat gat aaa aaa gag aag aag      459
 Ser Lys Asp Asp Asn Gln Asn Lys Thr His Asp Lys Lys Glu Lys Lys
          90                  95                 100

 atg gtg gtt cag aag ccc cat ggg act atg gaa tac act gtc ctt ttt      507
 Met Val Val Gln Lys Pro His Gly Thr Met Glu Tyr Thr Val Leu Phe
     105                 110                 115

 gtg cca gat gcc aac tct cct tcc agt acc tta agg cta tca tca tcc      555
 Val Pro Asp Ala Asn Ser Pro Ser Ser Thr Leu Arg Leu Ser Ser Ser
 120                 125                 130                 135

 agt cct ggt gct act gtc tct cct tca tca tca gat gca gaa tat gat      603
 Ser Pro Gly Ala Thr Val Ser Pro Ser Ser Ser Asp Ala Glu Tyr Asp
                 140                 145                 150

 aaa ttg cct gat gct gac tta gca cga aag gcc ttg aaa ccc att gaa      651
 Lys Leu Pro Asp Ala Asp Leu Ala Arg Lys Ala Leu Lys Pro Ile Glu
             155                 160                 165

 aga gtc tta tcg tct act tct gaa gaa gat gag cca ggt gtg gtg aaa      699
 Arg Val Leu Ser Ser Thr Ser Glu Glu Asp Glu Pro Gly Val Val Lys
         170                 175                 180

 ttt tta aaa atg aat tgt cga tac ttc acc gat gga aag ggt gtg gtt      747
 Phe Leu Lys Met Asn Cys Arg Tyr Phe Thr Asp Gly Lys Gly Val Val
     185                 190                 195

 ggc ggt gtt atg ata gtg act cct aac aac atc atg ttt gac cct cat      795
 Gly Gly Val Met Ile Val Thr Pro Asn Asn Ile Met Phe Asp Pro His
 200                 205                 210                 215

 aaa tct gat cct ctg gtt att gaa aat ggg tgt gag gag tat ggt ctc      843
 Lys Ser Asp Pro Leu Val Ile Glu Asn Gly Cys Glu Glu Tyr Gly Leu
                 220                 225                 230

 atc tgc ccc atg gaa gag gtt gtt tcc att gcg ctc tac aat gac att      891
 Ile Cys Pro Met Glu Glu Val Val Ser Ile Ala Leu Tyr Asn Asp Ile
             235                 240                 245

 tct cac atg aag atc aaa gat gcc ttg cca tcg cct gga gaa tgg gaa      939
 Ser His Met Lys Ile Lys Asp Ala Leu Pro Ser Pro Gly Glu Trp Glu
         250                 255                 260

 gac ctg gct tca gaa aag gat atc aac cca ttc agt aag ttc aaa tct      987
 Asp Leu Ala Ser Glu Lys Asp Ile Asn Pro Phe Ser Lys Phe Lys Ser
     265                 270                 275

 atc aac aag gaa aaa cga cag cag aat gga gag aaa att atg act tcg     1035
 Ile Asn Lys Glu Lys Arg Gln Gln Asn Gly Glu Lys Ile Met Thr Ser
 280                 285                 290                 295

 gat tcc aga cca ata gta cct ttg gag aag tcc aca gga cat aca cct     1083
 Asp Ser Arg Pro Ile Val Pro Leu Glu Lys Ser Thr Gly His Thr Pro
                 300                 305                 310

 aca aag ccc tca ggc agc tct gtg tca gag aaa tta aag aaa ctg gac     1131
 Thr Lys Pro Ser Gly Ser Ser Val Ser Glu Lys Leu Lys Lys Leu Asp
             315                 320                 325

 tcc tct agg gag aca tcc cat ggt tct ccc aca gtg act aag ctc agc     1179
 Ser Ser Arg Glu Thr Ser His Gly Ser Pro Thr Val Thr Lys Leu Ser
         330                 335                 340

 aag gaa cct tcc gac act tct tct gca ttt gaa tct aca gcc aaa gaa     1227
 Lys Glu Pro Ser Asp Thr Ser Ser Ala Phe Glu Ser Thr Ala Lys Glu
     345                 350                 355

 aac ttt cta ggg gaa gat gat gat ttt gtt gac ttg gaa gaa ctt tct     1275
 Asn Phe Leu Gly Glu Asp Asp Asp Phe Val Asp Leu Glu Glu Leu Ser
 360                 365                 370                 375

 tct caa act ggt ggt gga atg cac aaa aaa gac acc ttg aag gag tgc     1323
 Ser Gln Thr Gly Gly Gly Met His Lys Lys Asp Thr Leu Lys Glu Cys
                 380                 385                 390

 ctt tct ctt gac cca gag gaa cga aag aaa gct gag tca caa ata aac     1371
 Leu Ser Leu Asp Pro Glu Glu Arg Lys Lys Ala Glu Ser Gln Ile Asn
             395                 400                 405

 aat tct gcc gtg gaa atg cag gtg cag tca gcc cta gcc ttt ttg gga     1419
 Asn Ser Ala Val Glu Met Gln Val Gln Ser Ala Leu Ala Phe Leu Gly
         410                 415                 420

 aca gag aat gat gtt gaa ctg aag ggg gcg cta gat tta gaa acc tgt     1467
 Thr Glu Asn Asp Val Glu Leu Lys Gly Ala Leu Asp Leu Glu Thr Cys
     425                 430                 435

 gag aag caa gat ata atg cca gaa gtg gac aag cag tct ggt tcg cca     1515
 Glu Lys Gln Asp Ile Met Pro Glu Val Asp Lys Gln Ser Gly Ser Pro
 440                 445                 450                 455

 gaa agc cga gta gaa aac aca ctg aac ata cat gaa gat tta gat aaa     1563
 Glu Ser Arg Val Glu Asn Thr Leu Asn Ile His Glu Asp Leu Asp Lys
                 460                 465                 470

 gtt aaa ctc att gaa tat tac ctg act aag aac aaa gaa ggg cca cag     1611
 Val Lys Leu Ile Glu Tyr Tyr Leu Thr Lys Asn Lys Glu Gly Pro Gln
             475                 480                 485

 gta tct gaa aat ttg cag aaa aca gaa tta agt gat gga aaa agt att     1659
 Val Ser Glu Asn Leu Gln Lys Thr Glu Leu Ser Asp Gly Lys Ser Ile
         490                 495                 500

 gaa cca ggg gga ata gac att acc ctt agt agt tct ctt tcc cag gcg     1707
 Glu Pro Gly Gly Ile Asp Ile Thr Leu Ser Ser Ser Leu Ser Gln Ala
     505                 510                 515

 ggt gat ccc ata act gag ggc aat aaa gag cca gat aag acc tgg gtg     1755
 Gly Asp Pro Ile Thr Glu Gly Asn Lys Glu Pro Asp Lys Thr Trp Val
 520                 525                 530                 535

 aaa aag gga gag ccc ctc ccg gta aaa ctg aac tct tct aca gaa gca     1803
 Lys Lys Gly Glu Pro Leu Pro Val Lys Leu Asn Ser Ser Thr Glu Ala
                 540                 545                 550

 aat gtg att aaa gag gct cta gac tcc tct ttg gaa tct act ctg gac     1851
 Asn Val Ile Lys Glu Ala Leu Asp Ser Ser Leu Glu Ser Thr Leu Asp
             555                 560                 565

 aac agc tgt caa ggt gca caa atg gat aat aaa tct gaa gtt cag ttg     1899
 Asn Ser Cys Gln Gly Ala Gln Met Asp Asn Lys Ser Glu Val Gln Leu
         570                 575                 580

 tgg ctg tta aag aga att cag gta ccc att gaa ggt aag ctg ttt ttc     1947
 Trp Leu Leu Lys Arg Ile Gln Val Pro Ile Glu Gly Lys Leu Phe Phe
     585                 590                 595

 ttt aat gcc ttt ata ttc tgt tgc ata att gcc ttt cta caa ttt gca     1995
 Phe Asn Ala Phe Ile Phe Cys Cys Ile Ile Ala Phe Leu Gln Phe Ala
 600                 605                 610                 615

 cat gta ata ccc aca tta gta cat tta ttt gaa aac agt att ttc tca     2043
 His Val Ile Pro Thr Leu Val His Leu Phe Glu Asn Ser Ile Phe Ser
                 620                 625                 630

 ata gag tgt atc ttt gct gat agc att aac aat tgg gga gaa aat tta     2091
 Ile Glu Cys Ile Phe Ala Asp Ser Ile Asn Asn Trp Gly Glu Asn Leu
             635                 640                 645

 caa gat atg gta tct att ttg gaa ctt gga ctg tga                     2127
 Gln Asp Met Val Ser Ile Leu Glu Leu Gly Leu 
         650                 655





      <210> 518
      <211> 1125
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (1)..(1125)

      <400> 518
  atg gtc cta att cat gcc tct ggc ctg ctg ctg cag cag cag cta cct      48
  Met Val Leu Ile His Ala Ser Gly Leu Leu Leu Gln Gln Gln Leu Pro
    1               5                  10                  15

 ggg gct tgt gca gcc aag ggc cca gcc aga aca ccc agt aag gct ctc       96
 Gly Ala Cys Ala Ala Lys Gly Pro Ala Arg Thr Pro Ser Lys Ala Leu
              20                  25                  30

 tca ctt cct cag aag aag gaa gat att cat gat tac aat gat ata gac      144
 Ser Leu Pro Gln Lys Lys Glu Asp Ile His Asp Tyr Asn Asp Ile Asp
          35                  40                  45

 atg gca tgt ctt ctg gta ttg gat gac aag ctt gta ttt gta aaa gta      192
 Met Ala Cys Leu Leu Val Leu Asp Asp Lys Leu Val Phe Val Lys Val
      50                  55                  60

 cac gca cca tgg gag gtg tta tgt acg tat gct gag ata atg cac atc      240
 His Ala Pro Trp Glu Val Leu Cys Thr Tyr Ala Glu Ile Met His Ile
  65                  70                  75                  80

 aaa ttg cct ctg aaa ccc aat gat ctg aaa aac cgg tcc tca gcc ttt      288
 Lys Leu Pro Leu Lys Pro Asn Asp Leu Lys Asn Arg Ser Ser Ala Phe
                  85                  90                  95

 ggt aca ctc aac tgg ttt acc aaa gtc ctc agt gta gac gaa agc atc      336
 Gly Thr Leu Asn Trp Phe Thr Lys Val Leu Ser Val Asp Glu Ser Ile
             100                 105                 110

 atc aag cca gag caa gag ttt ttc act gcc cca ttt gag aag aac cgg      384
 Ile Lys Pro Glu Gln Glu Phe Phe Thr Ala Pro Phe Glu Lys Asn Arg
         115                 120                 125

 atg aat gat ttt tac ata gtt gat aga gat gct ttc ttc aat cca gcc      432
 Met Asn Asp Phe Tyr Ile Val Asp Arg Asp Ala Phe Phe Asn Pro Ala
     130                 135                 140

 acc aga agc cgc att atc cta ttg atc atc gct tca gtt att ggg atc      480
 Thr Arg Ser Arg Ile Ile Leu Leu Ile Ile Ala Ser Val Ile Gly Ile
 145                 150                 155                 160

 att gtc tat agg ctc tcg gtg ttc att gta ttt tct gca aaa ctt ccc      528
 Ile Val Tyr Arg Leu Ser Val Phe Ile Val Phe Ser Ala Lys Leu Pro
                 165                 170                 175

 aag aac att aat gga aca gac cca atc cag aaa tac ctg act cca cag      576
 Lys Asn Ile Asn Gly Thr Asp Pro Ile Gln Lys Tyr Leu Thr Pro Gln
             180                 185                 190

 aca gcc acg tcc atc acg gcc tcc atc atc agc ttt ata att atc atg      624
 Thr Ala Thr Ser Ile Thr Ala Ser Ile Ile Ser Phe Ile Ile Ile Met
         195                 200                 205

 att ctg aac acc ata tat gaa aaa gtg gca att atg att act aac ttc      672
 Ile Leu Asn Thr Ile Tyr Glu Lys Val Ala Ile Met Ile Thr Asn Phe
     210                 215                 220

 ggt aag gcc atg atc ata gct ttc acg tcg gac atg atc ccc cgc cta      720
 Gly Lys Ala Met Ile Ile Ala Phe Thr Ser Asp Met Ile Pro Arg Leu
 225                 230                 235                 240

 gtg tac tac tgg tcc ttc tcc gtc cct ccc tac ggg gac cac act tcc      768
 Val Tyr Tyr Trp Ser Phe Ser Val Pro Pro Tyr Gly Asp His Thr Ser
                 245                 250                 255

 tac acc atg gaa ggg tat cgt gat ttc cga tac cca cct gga cac ccc      816
 Tyr Thr Met Glu Gly Tyr Arg Asp Phe Arg Tyr Pro Pro Gly His Pro
             260                 265                 270

 cag gag tat aaa cac aac atc tac tat tgg cat gtg att gca gcc aag      864
 Gln Glu Tyr Lys His Asn Ile Tyr Tyr Trp His Val Ile Ala Ala Lys
         275                 280                 285

 ctg gct ttt atc att gtc atg gag ccc aaa atc tct ccc atc cac agt      912
 Leu Ala Phe Ile Ile Val Met Glu Pro Lys Ile Ser Pro Ile His Ser
     290                 295                 300

 att tcc ctc ttg att atg gca act cca tct caa cac tgc tca ggc cag      960
 Ile Ser Leu Leu Ile Met Ala Thr Pro Ser Gln His Cys Ser Gly Gln
 305                 310                 315                 320

 aat cct tgg aac cct aat gct ata tcc aat ctg gtt ggc ttt tcc ttt     1008
 Asn Pro Trp Asn Pro Asn Ala Ile Ser Asn Leu Val Gly Phe Ser Phe
                 325                 330                 335

 atc agt gag cac ttc aga cca att gtg ctg cta cca cca ggt cag aga     1056
 Ile Ser Glu His Phe Arg Pro Ile Val Leu Leu Pro Pro Gly Gln Arg
             340                 345                 350

 ttt ttg att gat aaa tta aaa aat gaa aag gtg ttt aac ctc att ggt     1104
 Phe Leu Ile Asp Lys Leu Lys Asn Glu Lys Val Phe Asn Leu Ile Gly
         355                 360                 365

 aat cag gaa aat gca gag taa                                         1125
 Asn Gln Glu Asn Ala Glu 
     370





      <210> 519
      <211> 3051
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (2651)..(2992)

      <400> 519
 gcggcccagg cccggaacct tccctggtcg tgcgccatat gtaaggccag ccgcggcagg     60

 accaaggcgg cggtgtcagc tcgcgagcct accctccgcg gacggtcttg ggtcgcctgc    120

 tgcctggctt gcctggtcgg cggcgggtgc cccgcgcgca cgcgcaaagc ccgccgcgtt    180

 cccagacccc aggccgcgct ctgtgggcct ctgagggcgg catgcgggac tacgacgagg    240

 tgaccgcctt cctgggcgag tgggggccct tccagcgcct catcttcttc ctgctcagcg    300

 ccagcatcat ccccaatggc ttcaccggcc tgtcctccgt gttcctgata gcgaccccgg    360

 agcaccgctg ccgggtgccg gacgccgcga acctgagcag cgcctggcgc aaccacactg    420

 tcccactgcg gctgcgggac ggccgcgagg tgccccacag ctgccgccgc taccggctcg    480

 ccaccatcgc caacttctcg gcgctcgggc tggagccggg gcgcgacgtg gacctggggc    540

 agctggagca ggagagctgt ctggatggct gggagttcag tcaggacgtc tacctgtcca    600

 ccattgtgac cgagtggaac ctggtgtgtg aggacgactg gaaggcccca ctcacaatct    660

 ccttgttctt cgtgggtgtg ctgttgggct ccttcatttc agggcagctg tcagacaggt    720

 ttggccggaa gaatgtgctg ttcgtgacca tgggcatgca gacaggcttc agcttcctgc    780

 agatcttctc gaagaatttt gagatgtttg tcgtgctgtt tgtccttgta ggcatgggcc    840

 agatctccaa ctatgtggca gcatttgtcc tggggacaga aattcttggc aagtcagttc    900

 gtataatatt ctctacgtta ggagtgtgca tattttatgc atttggctac atggtgctgc    960

 cactgtttgc ttacttcatc cgagactggc ggatgctgct ggtggcgctg acgatgccgg   1020

 gggtgctgtg cgtggcactc tggtggttca tccctgagtc cccccgatgg ctcatctctc   1080

 agggacgatt tgaagaggca gaggtgatca tccgcaaggc tgccaaagcc aatgggattg   1140

 ttgtgccttc cactatcttt gacccgagtg agttacaaga cctaagttcc aagaagcagc   1200

 agtcccacaa cattctggat ctgcttcgaa cctggaatat ccggatggtc accatcatgt   1260

 ccataatgct gtggatgacc atatcagtgg gctattttgg gctttcgctt gatactccta   1320

 acttgcatgg ggacatcttt gtgaactgct tcctttcagc gatggttgaa gtcccagcat   1380

 atgtgttggc ctggctgctg ctgcaatatt tgccccggcg ctattccatg gccactgccc   1440

 tcttcctggg tggcagtgtc cttctcttca tgcagctggt acccccagac ttgtattatt   1500

 tggctacagt cctggtgatg gtgggcaagt ttggagtcac ggctgccttt tccatggtct   1560

 acgtgtacac agccgagctg tatcccacag tggtgagaaa catgggtgtg ggagtcagct   1620

 ccacagcatc ccgcctgggc agcatcctgt ctccctactt cgtttacctt ggtgcctacg   1680

 accgcttcct gccctacatt ctcatgggaa gtctgaccat cctgacagcc atcctcacct   1740

 tgtttctccc agagagcttc ggtaccccac tcccagacac cattgaccag atgctaagag   1800

 tcaaaggaat gaaacacaga aaaactccaa gtcacacaag gatgttaaaa gatggtcaag   1860

 aaaggcccac aatccttaaa agcacagcct tctaacatcg cttccagtaa gggagaaact   1920

 gaagaggaaa gactgtcttg ccagaaatgg ccagcttgtg cagactccga gtccttcagt   1980

 gacaaaggcc tttgctgttt gtcctcttga cctgtgtctg acttgctcct ggatgggcac   2040

 ccacactcag aggctacata tggccctaga gcaccacctt cctctaggga cactggggct   2100

 acctacagac aacttcatct aagtcctaac tattacaatg atggactcag cacctccaaa   2160

 gcagttaatt tttcactaga accagtgaga tctggaggaa tgtgagaagc atatgctaaa   2220

 tgtacatttt aattttagac tacttgaaaa ggcccctaat aaggctagag gtctaagtcc   2280

 cccacccctt tccccactcc cctctagtgg tgaactttag aggaaaagga agtaattgca   2340

 caaggagttt gattcttacc ttttctcagt tacagaggac attaactgga tcattgcttc   2400

 cccagggcag gagagcgcag agctagggaa agtgaaaggt aatgaagatg gagcagaatg   2460

 agcagatgca gatcaccagc aaagtgcact gatgtgtgag ctcttaagac cactcagcat   2520

 gacgactgag tagacttgtt tacatctgat caaagcactg ggcttgtcca ggctcataat   2580

 aaatgctcca ttgaatctac tattcttgtt ttccactgct gtggaaacct ccttgctact   2640

 atagcgtctt   atg tat ggt tta aag gaa att tat cag gtg aga gag atg    2689
              Met Tyr Gly Leu Lys Glu Ile Tyr Gln Val Arg Glu Met
                1               5                  10

 agc aac gtt gtc ttt tct ctc aaa gct gta atg tgg gtt ttg ttt tac     2737
 Ser Asn Val Val Phe Ser Leu Lys Ala Val Met Trp Val Leu Phe Tyr
      15                  20                  25

 tgt tta ttt gtt tgt tgt tgt atc ctt ttc tcc ttg tta ttt gcc ctt     2785
 Cys Leu Phe Val Cys Cys Cys Ile Leu Phe Ser Leu Leu Phe Ala Leu
  30                  35                  40                  45

 cag aat gca ctt ggg aaa ggc tgg ttc ctt agc ctc ctg gtt tgt gtc     2833
 Gln Asn Ala Leu Gly Lys Gly Trp Phe Leu Ser Leu Leu Val Cys Val
                  50                  55                  60

 ttt ttt ttt ttt ttt tta aaa cac aaa atc act tgc cat ggg ggc agg     2881
 Phe Phe Phe Phe Phe Leu Lys His Lys Ile Thr Cys His Gly Gly Arg
              65                  70                  75

 gct tta cca ccc tta cct ttt acc ttt ttt tta agg gca aaa acc ggg     2929
 Ala Leu Pro Pro Leu Pro Phe Thr Phe Phe Leu Arg Ala Lys Thr Gly
          80                  85                  90

 gca ttg ggg ggg gtc ctt ttt tgg aca cta agc cgg ggg ggg att tcc     2977
 Ala Leu Gly Gly Val Leu Phe Trp Thr Leu Ser Arg Gly Gly Ile Ser
      95                 100                 105

 caa aaa aaa att taa attggggtct catagtcttt aaaagaacct cattttaccc     3032
 Gln Lys Lys Ile 
 110

 cggcaccttt atggggggg                                                3051




      <210> 520
      <211> 1479
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (367)..(903)

      <220>
      <221> misc_feature
      <222> (1)...(1479)
      <223> n = a,t,c or g

      <400> 520
 atggaagcca taagacagaa aattgcccaa ctccccactt tccgagtgcc aaatgactca     60

 tctccgcagc cccctccttc cctgaactct cattccagtg aaggaagtgc ccttcgccag    120

 tgcttgagag accatccact cccaccttcc tgggtgaatc tgaatggtgc ctaccctaag    180

 ctggtgcctt tcagacctgc aggacggctg atctctccac ctctgctact ctctgtgatt    240

 ttcaacattc ttcnnnnnnn nnnnnnnnnn nnnncaggct tcatcctggt tcacaggcag    300

 ccttggtatt ccgtggagat acacagtgcc tgcacagtac aaaatgaaag catctcagag    360

 ttaacc   atg tct cca act gct cca gaa aaa atg gaa agt aat agc acc     408
          Met Ser Pro Thr Ala Pro Glu Lys Met Glu Ser Asn Ser Thr
            1               5                  10

 ttc aca agt ttt gag aac act aca gtc tgg ttc ttg gga aca atc aac      456
 Phe Thr Ser Phe Glu Asn Thr Thr Val Trp Phe Leu Gly Thr Ile Asn
  15                  20                  25                  30

 tgt atc act gtg gct ctt gtg ttc tct aaa gga aaa cca ttt aga cag      504
 Cys Ile Thr Val Ala Leu Val Phe Ser Lys Gly Lys Pro Phe Arg Gln
                  35                  40                  45

 cca act tat aca aac tat ata ttt gtc ctt gtg ctg ata ata cag ctt      552
 Pro Thr Tyr Thr Asn Tyr Ile Phe Val Leu Val Leu Ile Ile Gln Leu
              50                  55                  60

 ggt gta tgt cta ttc att cta ttt gct gat ata cca gaa tta tat aga      600
 Gly Val Cys Leu Phe Ile Leu Phe Ala Asp Ile Pro Glu Leu Tyr Arg
          65                  70                  75

 cgt ttg gat ctg ctc tgc act ccc gtc ctg tgg agg gcc tcc att gtc      648
 Arg Leu Asp Leu Leu Cys Thr Pro Val Leu Trp Arg Ala Ser Ile Val
      80                  85                  90

 atc atg ctc agc ttg aat ttc att gtg tcc ctt gtg gcc gag gag gct      696
 Ile Met Leu Ser Leu Asn Phe Ile Val Ser Leu Val Ala Glu Glu Ala
  95                 100                 105                 110

 gtt att gaa aat cga gcc ctg tgg atg atg att aaa aga tgt ttc ggc      744
 Val Ile Glu Asn Arg Ala Leu Trp Met Met Ile Lys Arg Cys Phe Gly
                 115                 120                 125

 tat cag tca aaa agc cag tat cgg ata tgg cag agg gac ttg gca aat      792
 Tyr Gln Ser Lys Ser Gln Tyr Arg Ile Trp Gln Arg Asp Leu Ala Asn
             130                 135                 140

 gac cct agt tgg ccc ccg cta aac caa acc tcc cac tct gac atg ccg      840
 Asp Pro Ser Trp Pro Pro Leu Asn Gln Thr Ser His Ser Asp Met Pro
         145                 150                 155

 gag tgt ggc aga gga gtg tct tac agc aat cca gta ttt gag agc aat      888
 Glu Cys Gly Arg Gly Val Ser Tyr Ser Asn Pro Val Phe Glu Ser Asn
     160                 165                 170

 gaa gaa caa ctc tga aggacatgtg atatccaagt tgatattaca gagaaacaat      943
 Glu Glu Gln Leu 
 175

 gacaaaaggg accagtttca ttgattttaa gaaatgagac tcttgtaaca tcagctggag   1003

 ttttggggct acctatcaaa tcatggtgac aaactaaagt ctgtttgata aaatactgtc   1063

 tacagagaag aacattgacc cagaagagtg ctttcctctt ggcttctgaa ggtattagag   1123

 gcattcagtg aaggcaagaa tgggccaaga atttctatgg gccaagagac aagcaggcta   1183

 aaggggaaaa atatgtgatc tttcctctta ggacaggaca atactttcct ttttataaaa   1243

 atgagttgag gggaagtagt actgtgtata ctcacggagt tgtaattttt gaatttttac   1303

 ttcatcgatg gaaaaactaa tgcgtgggaa acattacacc aatctttact gtctgggttc   1363

 cttttctctg tagtactttt cagatttgag gctttttctt ctgtttctgg ccttacccaa   1423

 catattgtta aggataagct taacttatgc tgcaataaaa aacaactctc agataa       1479




      <210> 521
      <211> 785
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (265)..(774)

      <400> 521
 ccgccgccgg aggctgcacc tgcctcagag gatgcccagg agcccgcggg agcctctccg     60

 gatcagaact ttttaggccg cccgccccca tccccgcagt ccccgggccg tgctccggta    120

 ggcgggggcc gagggggcgc cgcggcgcga gtccctctcc tgccccctcc cccagctcgg    180

 ccgcccgccg ctttgttccg ggtgcggcga gggaaggcga ggctgcggcg gatcatgccc    240

 atggtgtagc cgccaagcgg aggc   atg gct gcc gga agg tta ctg ctc tac     291
                              Met Ala Ala Gly Arg Leu Leu Leu Tyr
                                1               5

 act ggc ctc tcg cta gcg ctc tgc gcc ctc ggc atg ctg gcc gtg gcc      339
 Thr Gly Leu Ser Leu Ala Leu Cys Ala Leu Gly Met Leu Ala Val Ala
  10                  15                  20                  25

 atc tgc tcg gac cac tgg tac gag acg gac gcc agg aag cac agg gac      387
 Ile Cys Ser Asp His Trp Tyr Glu Thr Asp Ala Arg Lys His Arg Asp
                  30                  35                  40

 agg tgc aag gcc ttc aac acc cgc cgg gtc gac ccc ggc ttc att tac      435
 Arg Cys Lys Ala Phe Asn Thr Arg Arg Val Asp Pro Gly Phe Ile Tyr
              45                  50                  55

 aac aat aac aac aac ttg ccg ctc cgg gcg agc cgc tcg cgc ctg gac      483
 Asn Asn Asn Asn Asn Leu Pro Leu Arg Ala Ser Arg Ser Arg Leu Asp
          60                  65                  70

 cgc tgg gag ggc aaa ctc ctc cgg gcc cgg aat cgc cgg cag ctg ttc      531
 Arg Trp Glu Gly Lys Leu Leu Arg Ala Arg Asn Arg Arg Gln Leu Phe
      75                  80                  85

 gcc atg agc ccc gcg gac gag tgc agc cgg cag tac aac tcc acc aac      579
 Ala Met Ser Pro Ala Asp Glu Cys Ser Arg Gln Tyr Asn Ser Thr Asn
  90                  95                 100                 105

 atg ggc ctc tgg agg aag tgc cac cgg cag ggc ttc gac ccg gag atc      627
 Met Gly Leu Trp Arg Lys Cys His Arg Gln Gly Phe Asp Pro Glu Ile
                 110                 115                 120

 gcc gcc ctc att cgg aaa gga gaa att gag cga tgt acg tac atc aaa      675
 Ala Ala Leu Ile Arg Lys Gly Glu Ile Glu Arg Cys Thr Tyr Ile Lys
             125                 130                 135

 tac cac tac tcc tca gca acc atc ccc agg aac ctc act ttc aat atc      723
 Tyr His Tyr Ser Ser Ala Thr Ile Pro Arg Asn Leu Thr Phe Asn Ile
         140                 145                 150

 acg aag acc atc cgt cag gat gag tgg cat gcc cta cgt aag tgc acc      771
 Thr Lys Thr Ile Arg Gln Asp Glu Trp His Ala Leu Arg Lys Cys Thr
     155                 160                 165

 tga gtctcattgg c                                                     785
 






      <210> 522
      <211> 1527
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (265)..(1182)

      <220>
      <221> misc_feature
      <222> (1)...(1527)
      <223> n = a,t,c or g

      <400> 522
 ccgccgccgg aggctgcacc tgcctcagag gatgcccagg agcccgcggg agcctctccg     60

 gatcagaact ttttaggccg cccgccccca tccccgcagt ccccgggccg tgctccggta    120

 ggcgggggcc gagggggcgc cgcggcgcga gtccctctcc tgccccctcc cccagctcgg    180

 ccgcccgccg ctttgttccg ggtgcggcga gggaaggcga ggctgcggcg gatcatgccc    240

 atggtgtagc cgccaagcgg aggc   atg gct gcc gga agg tta ctg ctc tac     291
                              Met Ala Ala Gly Arg Leu Leu Leu Tyr
                                1               5

 act ggc ctc tcg cta gcg ctc tgc gcc ctc ggc atg ctg gcc gtg gcc      339
 Thr Gly Leu Ser Leu Ala Leu Cys Ala Leu Gly Met Leu Ala Val Ala
  10                  15                  20                  25

 atc tgc tcg gac cac tgg tac gag acg gac gcc agg aag cac agg gac      387
 Ile Cys Ser Asp His Trp Tyr Glu Thr Asp Ala Arg Lys His Arg Asp
                  30                  35                  40

 agg tgc aag gcc ttc aac acc cgc cgg gtc gac ccc ggc ttc att tac      435
 Arg Cys Lys Ala Phe Asn Thr Arg Arg Val Asp Pro Gly Phe Ile Tyr
              45                  50                  55

 aac aat aac aac aac ttg ccg ctc cgg gcg agc cgc tcg cgc ctg gac      483
 Asn Asn Asn Asn Asn Leu Pro Leu Arg Ala Ser Arg Ser Arg Leu Asp
          60                  65                  70

 cgc tgg gag ggc aaa ctc ctc cgg gcc cgg aat cgc cgg cag ctg ttc      531
 Arg Trp Glu Gly Lys Leu Leu Arg Ala Arg Asn Arg Arg Gln Leu Phe
      75                  80                  85

 gcc atg agc ccc gcg gac gag tgc agc cgg cag tac aac tcc acc aac      579
 Ala Met Ser Pro Ala Asp Glu Cys Ser Arg Gln Tyr Asn Ser Thr Asn
  90                  95                 100                 105

 atg ggc ctc tgg agg aag tgc cac cgg cag ggc ttc gac ccg gag atc      627
 Met Gly Leu Trp Arg Lys Cys His Arg Gln Gly Phe Asp Pro Glu Ile
                 110                 115                 120

 gcc gcc ctc att cgg aaa gga gaa att gag cga tgt acg tac atc aaa      675
 Ala Ala Leu Ile Arg Lys Gly Glu Ile Glu Arg Cys Thr Tyr Ile Lys
             125                 130                 135

 tac cac tac tcc tca gca acc atc ccc agg aac ctc act ttc aat atc      723
 Tyr His Tyr Ser Ser Ala Thr Ile Pro Arg Asn Leu Thr Phe Asn Ile
         140                 145                 150

 acg aag acc atc cgt cag gat gag tgg cat gcc cta cgc att gcc ctt      771
 Thr Lys Thr Ile Arg Gln Asp Glu Trp His Ala Leu Arg Ile Ala Leu
     155                 160                 165

 tca gca cag gtg ggg cct ggg cct ttc cca gtg tgg cac aac aag ggg      819
 Ser Ala Gln Val Gly Pro Gly Pro Phe Pro Val Trp His Asn Lys Gly
 170                 175                 180                 185

 agg tgg ctg ata ggg agt ggg ggg tct gcg aca gga cct ggg cag cca      867
 Arg Trp Leu Ile Gly Ser Gly Gly Ser Ala Thr Gly Pro Gly Gln Pro
                 190                 195                 200

 ggg tgg gct ata tca gag gaa gct gag aaa aca ggg gat ggg aag atg      915
 Gly Trp Ala Ile Ser Glu Glu Ala Glu Lys Thr Gly Asp Gly Lys Met
             205                 210                 215

 tcg ctg aga ggg gaa ctg tcc cag ttc cag gtg ctg aaa agg gag ctt      963
 Ser Leu Arg Gly Glu Leu Ser Gln Phe Gln Val Leu Lys Arg Glu Leu
         220                 225                 230

 aat atg gca ggc tct atc tta tta tct aaa act gga tcc ccc aaa ttg     1011
 Asn Met Ala Gly Ser Ile Leu Leu Ser Lys Thr Gly Ser Pro Lys Leu
     235                 240                 245

 gat acc ctc aac tcc cat gat gaa cgt tca gac ttc tct gtc cct tgt     1059
 Asp Thr Leu Asn Ser His Asp Glu Arg Ser Asp Phe Ser Val Pro Cys
 250                 255                 260                 265

 agc cag ccc ctg ata caa gat cga tgt ttg ccc ctt gat gtg ccc tgt     1107
 Ser Gln Pro Leu Ile Gln Asp Arg Cys Leu Pro Leu Asp Val Pro Cys
                 270                 275                 280

 gta ggc ttg tat gaa gtc cag aaa ccc aac caa ggg aca tcc agt gtc     1155
 Val Gly Leu Tyr Glu Val Gln Lys Pro Asn Gln Gly Thr Ser Ser Val
             285                 290                 295

 ctt ggt gct ggg atc atc cag tct tag gcccc agtctcagtt cacgttggta     1207
 Leu Gly Ala Gly Ile Ile Gln Ser 
         300                 305

 aagtgagacc cattctgcca cgtttccctg aggctctttg cttgggcgcc tggcaccaaa   1267

 ttagaaatga gcaatcaggt gtgtgtggtg tgtgtcagct tccgaaacca cgaggctgct   1327

 aaacatgggt gtggaggtga cacatttgac tgacatcagc atctgtgttc catccaccac   1387

 cccatccact gcctcactct tggagcttct agggctgcac agttgccaag gaaactagaa   1447

 naagctactg tgcacaagtc acctcctccc cagagctcat gggaacaccc tcttgggggg   1507

 agggtgtgaa gaatgaatga                                               1527




      <210> 523
      <211> 636
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (104)..(433)

      <400> 523
 tttctttttc tttttttttg attcttcagc taagacagca gaagagatga tttatcgtat     60

 ggttgttata ctcggccaca agtaaacaca gaaatagtcc aga  atg tcc cag gtc     115
                                                  Met Ser Gln Val
                                                    1

 cag ggc aga gga cca aca tgg gca gtt ttg gtt atg agc aag gtg ggt      163
 Gln Gly Arg Gly Pro Thr Trp Ala Val Leu Val Met Ser Lys Val Gly
   5                  10                  15                  20

 ctc aga ggt gat cag cga tca gag ggc ggt gaa gtt ctg gat cca ttg      211
 Leu Arg Gly Asp Gln Arg Ser Glu Gly Gly Glu Val Leu Asp Pro Leu
                  25                  30                  35

 aga caa gct cta cac aat agc atg cag tcc cac aac ttg tac cag cat      259
 Arg Gln Ala Leu His Asn Ser Met Gln Ser His Asn Leu Tyr Gln His
              40                  45                  50

 ccc cag cat ctg gca ttc cat gtt tct gct cct gtg tgg cct cca cgg      307
 Pro Gln His Leu Ala Phe His Val Ser Ala Pro Val Trp Pro Pro Arg
          55                  60                  65

 tgc aac aag cta gcg gtt tac ttg gac ctc tgc ctc atc ttt ctt ctt      355
 Cys Asn Lys Leu Ala Val Tyr Leu Asp Leu Cys Leu Ile Phe Leu Leu
      70                  75                  80

 ttg tgc ttc aga ctg cac att cgc ttt ttc ctc cac tta gct ctc atg      403
 Leu Cys Phe Arg Leu His Ile Arg Phe Phe Leu His Leu Ala Leu Met
  85                  90                  95                 100

 atg cag agg ttt cca aga aaa tgg cgc taa g gccaagagaa accctagccc      454
 Met Gln Arg Phe Pro Arg Lys Trp Arg 
                 105

 atttctattg tcagttttta ttgaattcca ccttggacgc tcttctaggt tcttgggtta    514

 caccagtaaa caaaaagatt tctgctcttg aggagcttat attctatcag aggaacacag    574

 acaataaata tcagtaagct ttccagtatg ttagaatgtg ataagtggtg tggaaaaaag    634

 aa                                                                   636




      <210> 524
      <211> 1569
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (205)..(1311)

      <400> 524
 atgggcgagc accccagccc gggccccgcg gtggccgcct gcgccgaggc ggagcgcatc     60

 gaggagctgg aacccgaggc cgaggagcgg ctgcccgcgg cgccggagga cggtggggag    120

 atggaagtga aaccaggccc ccaacccaca caacgaaagc gggaaagtct gaatggggtt    180

 gggggactgg ggaaggagcc ccag   atg gca gca ata caa aga gag aat ctg     231
                              Met Ala Ala Ile Gln Arg Glu Asn Leu
                                1               5

 ttt gac cct ggg aac aca ggc tac att agc aca ggc aag ttc cgg agt      279
 Phe Asp Pro Gly Asn Thr Gly Tyr Ile Ser Thr Gly Lys Phe Arg Ser
  10                  15                  20                  25

 ctt ctg gag agc cac agc tcc aag ctg gac ccg cac aaa agg gag gtc      327
 Leu Leu Glu Ser His Ser Ser Lys Leu Asp Pro His Lys Arg Glu Val
                  30                  35                  40

 ctc ctg gct ctt gcc gac agc cac gcg gat ggg cag atc ggc tac cag      375
 Leu Leu Ala Leu Ala Asp Ser His Ala Asp Gly Gln Ile Gly Tyr Gln
              45                  50                  55

 gat ttt gtc agc cta atg agc aac aag cgt tcc aac agc ttc cgc caa      423
 Asp Phe Val Ser Leu Met Ser Asn Lys Arg Ser Asn Ser Phe Arg Gln
          60                  65                  70

 gcc atc ctg cag ggc aac cgc agg cta agc agc aag gcc ctg ctg gag      471
 Ala Ile Leu Gln Gly Asn Arg Arg Leu Ser Ser Lys Ala Leu Leu Glu
      75                  80                  85

 gag aag ggg ctg agc ctc tcg cag cga ctt atc cgc cat gtg gcc tat      519
 Glu Lys Gly Leu Ser Leu Ser Gln Arg Leu Ile Arg His Val Ala Tyr
  90                  95                 100                 105

 gag acc ctg ccc cgg gaa att gac cgc aag tgg tac tat gac agc tac      567
 Glu Thr Leu Pro Arg Glu Ile Asp Arg Lys Trp Tyr Tyr Asp Ser Tyr
                 110                 115                 120

 acc tgc tgc ccc cca ccc tgg ttc atg atc aca gtc acg ctg ctg gag      615
 Thr Cys Cys Pro Pro Pro Trp Phe Met Ile Thr Val Thr Leu Leu Glu
             125                 130                 135

 gtt gcc ttt ttc ctc tac aat tgg gtg tca cta ggt caa ttt gta ctg      663
 Val Ala Phe Phe Leu Tyr Asn Trp Val Ser Leu Gly Gln Phe Val Leu
         140                 145                 150

 cag gta act cat cca cgt tac ttg aag aac tcc ctg gtt tac cac cca      711
 Gln Val Thr His Pro Arg Tyr Leu Lys Asn Ser Leu Val Tyr His Pro
     155                 160                 165

 cag ctg cga gca cag gtt tgg cgc tac ctg aca tac atc ttc atg cat      759
 Gln Leu Arg Ala Gln Val Trp Arg Tyr Leu Thr Tyr Ile Phe Met His
 170                 175                 180                 185

 gca ggg ata gaa cac ctg gga ctc aat gtg gtg ctg cag ctg ctg gtg      807
 Ala Gly Ile Glu His Leu Gly Leu Asn Val Val Leu Gln Leu Leu Val
                 190                 195                 200

 ggg gtg ccc ctg gag atg gtg cat gga gcc acc cga att ggg ctt gtc      855
 Gly Val Pro Leu Glu Met Val His Gly Ala Thr Arg Ile Gly Leu Val
             205                 210                 215

 tac atg gcc ggt gtt gtg gca ggg tcc ttg gca gtg tct gtg gct gac      903
 Tyr Met Ala Gly Val Val Ala Gly Ser Leu Ala Val Ser Val Ala Asp
         220                 225                 230

 atg acc gct cca gtc gtg ggc tct tct gga ggg gtg tat gct ctc gtc      951
 Met Thr Ala Pro Val Val Gly Ser Ser Gly Gly Val Tyr Ala Leu Val
     235                 240                 245

 tct gcc cat ctg gcc aac att gtc atg aac tgg tca ggc atg aag tgc      999
 Ser Ala His Leu Ala Asn Ile Val Met Asn Trp Ser Gly Met Lys Cys
 250                 255                 260                 265

 cag ttc aag ctg ctg cgg atg gct gtg gcc ctt atc tgt atg agc atg     1047
 Gln Phe Lys Leu Leu Arg Met Ala Val Ala Leu Ile Cys Met Ser Met
                 270                 275                 280

 gag ttt ggg cgg gcc gtg tgg ctc cgc ttc cac ccg tcg gcc tat ccc     1095
 Glu Phe Gly Arg Ala Val Trp Leu Arg Phe His Pro Ser Ala Tyr Pro
             285                 290                 295

 ccg tgc cct cac cca agc ttt gtg gcg cac ttg ggt ggc gtg gcc gtg     1143
 Pro Cys Pro His Pro Ser Phe Val Ala His Leu Gly Gly Val Ala Val
         300                 305                 310

 ggc atc acc ctg ggc gtg gtg gtc ctg agg aac tac gag cag agg ctc     1191
 Gly Ile Thr Leu Gly Val Val Val Leu Arg Asn Tyr Glu Gln Arg Leu
     315                 320                 325

 cag gac cag tca ctg tgg tgg att ttt gtg gcc atg tac acc gtc ttc     1239
 Gln Asp Gln Ser Leu Trp Trp Ile Phe Val Ala Met Tyr Thr Val Phe
 330                 335                 340                 345

 gtg ctg ttc gct gtc ttc tgg aac atc ttt gcc tac acc ctg ctg gac     1287
 Val Leu Phe Ala Val Phe Trp Asn Ile Phe Ala Tyr Thr Leu Leu Asp
                 350                 355                 360

 tta aag ctg ccg cct ccc ccc tga ggcttgaggc cccagtccgc gaggggaggg    1341
 Leu Lys Leu Pro Pro Pro Pro 
             365

 aaagcaggac cccagggagc gcctggaagg ttcttcctca tcacaggttc agtaagcggg   1401

 caaacacgca caaacactgc gcctgtattg tgttatttgg ccacgggggc acctctgcga   1461

 agggctgcgg gcgaaacaca agacaaacgg actaacacaa gaacaagggg cgaatcatcg   1521

 cgcgggagca cttggaaagc aggttaaaac gggacacaag gacacttt                1569




      <210> 525
      <211> 770
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (165)..(485)

      <400> 525
 tcgagttgtg ctatctctat ctctaacata gttttcaagg agaaaacatt cttaatttta     60

 atgaagtcca atgtatccat cctttttctt ctatggattg tacttttggt atcagaccta    120

 atatctttgc cagtctgaga gatatgtcag agagctgagc agcc atg aca gcc tat     176
                                                  Met Thr Ala Tyr
                                                    1

 ttc aat gaa cag gac tgc aag ctc ttg aac ccc aag cag gag acc cta      224
 Phe Asn Glu Gln Asp Cys Lys Leu Leu Asn Pro Lys Gln Glu Thr Leu
   5                  10                  15                  20

 acc cac atg ctg ctg gag ctc tcc aga tca ctt ttc aat agg atg gat      272
 Thr His Met Leu Leu Glu Leu Ser Arg Ser Leu Phe Asn Arg Met Asp
                  25                  30                  35

 ttt gaa gac tcg ggg atg gca gta aat tgg aat cac cac ctg cct cca      320
 Phe Glu Asp Ser Gly Met Ala Val Asn Trp Asn His His Leu Pro Pro
              40                  45                  50

 cca gct gcc aag aca gtg tgg ttg gga acc tcc cca gga gag tca tca      368
 Pro Ala Ala Lys Thr Val Trp Leu Gly Thr Ser Pro Gly Glu Ser Ser
          55                  60                  65

 gga gct ctc agg ctg aga gac aca cac aag tgc ccc atg tgc ttg agg      416
 Gly Ala Leu Arg Leu Arg Asp Thr His Lys Cys Pro Met Cys Leu Arg
      70                  75                  80

 agg agg agg ctg ttg ttg gga tgc ctt gcc att agc ttt tcc att cta      464
 Arg Arg Arg Leu Leu Leu Gly Cys Leu Ala Ile Ser Phe Ser Ile Leu
  85                  90                  95                 100

 act gca ttt tgc ccc ggc taa gc aagacaaatc cctgtccctt gtgctgccag      517
 Thr Ala Phe Cys Pro Gly 
                 105

 gagctgcccg ctgttaacga cacttgtgag gagcacagag gagataaggc tcgaaacagc    577

 agcagcagca gcactgtctg gagaacctct acagagccat gtgcatatga ggaggctggg    637

 gctaagcgct ggctctctac aaggtcctcc tcttacacct tgaaccctca ttaaaggttt    697

 ctttacccac aaacacaaga aaatatcttt gcctaatcca agaccacaaa gattttatcc    757

 catttttttc ctg                                                       770




      <210> 526
      <211> 4650
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (317)..(3700)

      <400> 526
 ccggatttcc cgggggcctg ggtggactct acagggaaat gttgttttct ccctgggagc     60

 agtagcagca gtcctggctc ccctggactg agaactcctc atcagcccca ggaagcccga    120

 accccctttc agggatctgg aaccggtgtg cctgtggccc caggtctgct cccaggcgtg    180

 ggctgaagtc ctgacttctg tcgctggggg caaggagtgg gagagcccag ctgctgcctg    240

 ggctttggca gacagcaggc tgatggtgct ggcttccccg agactgcttc tcctgcctgc    300

 tgtctgattt ccctgc    atg gtg ccc gca gct gag ctg cta cgg ggc tgg     349
                      Met Val Pro Ala Ala Glu Leu Leu Arg Gly Trp
                        1               5                  10

 ctt ctc tca ctg gtc agg ggt ctt ctc ccc tgt ctg cct ccc gga gct      397
 Leu Leu Ser Leu Val Arg Gly Leu Leu Pro Cys Leu Pro Pro Gly Ala
              15                  20                  25

 agg act gca gag ggg cct atc atg gtg ctt gca ggc ccc ctg gct gtc      445
 Arg Thr Ala Glu Gly Pro Ile Met Val Leu Ala Gly Pro Leu Ala Val
          30                  35                  40

 tcg ctg ttg ctg ccc agc ctc aca ctg ctg gtg tcc cac ctc tcc agc      493
 Ser Leu Leu Leu Pro Ser Leu Thr Leu Leu Val Ser His Leu Ser Ser
      45                  50                  55

 tcc cag gat gtc tcc agt gag ccc agc agt gag cag cag ctg tac gcc      541
 Ser Gln Asp Val Ser Ser Glu Pro Ser Ser Glu Gln Gln Leu Tyr Ala
  60                  65                  70                  75

 ctt agc aag cac ccc acc gtg gcc ttt gaa gac ctg cag ccg tgg gtc      589
 Leu Ser Lys His Pro Thr Val Ala Phe Glu Asp Leu Gln Pro Trp Val
                  80                  85                  90

 tct aac ttc acc tac cct gga gcc cgg gat ttc tcc cag ctg gct ttg      637
 Ser Asn Phe Thr Tyr Pro Gly Ala Arg Asp Phe Ser Gln Leu Ala Leu
              95                 100                 105

 gac ccc tcc ggg aac cag ctc atc gtg gga gcc agg aac tac ctc ttc      685
 Asp Pro Ser Gly Asn Gln Leu Ile Val Gly Ala Arg Asn Tyr Leu Phe
         110                 115                 120

 aga ctc agc ctt gcc aat gtc tct ctt ctt cag gcc aca gag tgg gcc      733
 Arg Leu Ser Leu Ala Asn Val Ser Leu Leu Gln Ala Thr Glu Trp Ala
     125                 130                 135

 tcc agt gag gac acg cgc cgc tcc tgc caa agc aaa ggg aag act gag      781
 Ser Ser Glu Asp Thr Arg Arg Ser Cys Gln Ser Lys Gly Lys Thr Glu
 140                 145                 150                 155

 gag gag tgt cag aac tac gtg cga gtc ctg atc gtc gcc ggc cgg aag      829
 Glu Glu Cys Gln Asn Tyr Val Arg Val Leu Ile Val Ala Gly Arg Lys
                 160                 165                 170

 gtg ttc atg tgt gga acc aat gcc ttt tcc ccc atg tgc acc agc aga      877
 Val Phe Met Cys Gly Thr Asn Ala Phe Ser Pro Met Cys Thr Ser Arg
             175                 180                 185

 cag gtg ggg aac ctc agc cgg act act gag aag atc aat ggt gtg gcc      925
 Gln Val Gly Asn Leu Ser Arg Thr Thr Glu Lys Ile Asn Gly Val Ala
         190                 195                 200

 cgc tgc ccc tat gac cca cgc cac aac tcc aca gct gtc atc tcc tcc      973
 Arg Cys Pro Tyr Asp Pro Arg His Asn Ser Thr Ala Val Ile Ser Ser
     205                 210                 215

 cag ggg gag ctc tat gca gcc acg gtc atc gac ttc tca ggt cgg gac     1021
 Gln Gly Glu Leu Tyr Ala Ala Thr Val Ile Asp Phe Ser Gly Arg Asp
 220                 225                 230                 235

 cct gcc atc tac cgc agc ctg ggc agt ggg cca ccg ctt cgc act gcc     1069
 Pro Ala Ile Tyr Arg Ser Leu Gly Ser Gly Pro Pro Leu Arg Thr Ala
                 240                 245                 250

 caa tat aac tcc aag tgg ctt aat gag cca aac ttc gtg gca gcc tat     1117
 Gln Tyr Asn Ser Lys Trp Leu Asn Glu Pro Asn Phe Val Ala Ala Tyr
             255                 260                 265

 gat att ggg ctg ttt gca tac ttc ttc ctg cgg gag aac gca gtg gag     1165
 Asp Ile Gly Leu Phe Ala Tyr Phe Phe Leu Arg Glu Asn Ala Val Glu
         270                 275                 280

 cac gac tgt gga cgc acc gtg tac tct cgc gtg gcc cgc gtg tgc aag     1213
 His Asp Cys Gly Arg Thr Val Tyr Ser Arg Val Ala Arg Val Cys Lys
     285                 290                 295

 aat gac gtg ggg ggc cga ttc ctg ctg gag gac aca tgg acc aca ttc     1261
 Asn Asp Val Gly Gly Arg Phe Leu Leu Glu Asp Thr Trp Thr Thr Phe
 300                 305                 310                 315

 atg aag gcc cgg ctc aac tgc tcc cgc ccg ggc gag gtc ccc ttc tac     1309
 Met Lys Ala Arg Leu Asn Cys Ser Arg Pro Gly Glu Val Pro Phe Tyr
                 320                 325                 330

 tat aac gag ctg cag agt gcc ttc cac ttg cca gag cag gac ctc atc     1357
 Tyr Asn Glu Leu Gln Ser Ala Phe His Leu Pro Glu Gln Asp Leu Ile
             335                 340                 345

 tat gga gtt ttc aca acc aac gta aac agc atc gcg gct tct gct gtc     1405
 Tyr Gly Val Phe Thr Thr Asn Val Asn Ser Ile Ala Ala Ser Ala Val
         350                 355                 360

 tgc gcc ttc aac ctc agt gct atc tcc cag gct ttc aat ggc cca ttt     1453
 Cys Ala Phe Asn Leu Ser Ala Ile Ser Gln Ala Phe Asn Gly Pro Phe
     365                 370                 375

 cgc tac cag gag aac ccc agg gct gcc tgg ctc ccc ata gcc aac ccc     1501
 Arg Tyr Gln Glu Asn Pro Arg Ala Ala Trp Leu Pro Ile Ala Asn Pro
 380                 385                 390                 395

 atc ccc aat ttc cag tgt ggc acc ctg cct gag acc ggt ccc aac gag     1549
 Ile Pro Asn Phe Gln Cys Gly Thr Leu Pro Glu Thr Gly Pro Asn Glu
                 400                 405                 410

 aac ctg acg gag cgc agc ctg cag gac gcg cag cgc ctc ttc ctg atg     1597
 Asn Leu Thr Glu Arg Ser Leu Gln Asp Ala Gln Arg Leu Phe Leu Met
             415                 420                 425

 agc gag gcc gtg cag ccg gtg aca ccc gag ccc tgt gtc acc cag gac     1645
 Ser Glu Ala Val Gln Pro Val Thr Pro Glu Pro Cys Val Thr Gln Asp
         430                 435                 440

 agc gtg cgc ttc tca cac ctc gtg gtg gac ctg gtg cag gct aaa gac     1693
 Ser Val Arg Phe Ser His Leu Val Val Asp Leu Val Gln Ala Lys Asp
     445                 450                 455

 acg ctc tac cat gta ctc tac att ggc acc gag tcg ggc acc atc ctg     1741
 Thr Leu Tyr His Val Leu Tyr Ile Gly Thr Glu Ser Gly Thr Ile Leu
 460                 465                 470                 475

 aag gcg ctg tcc acg gcg agc cgc agc ctc cac ggc tgc tac ctg gag     1789
 Lys Ala Leu Ser Thr Ala Ser Arg Ser Leu His Gly Cys Tyr Leu Glu
                 480                 485                 490

 gag ctg cac gtg ctg ccc ccc ggg cgc cgc gag ccc ctg cgc agc ctg     1837
 Glu Leu His Val Leu Pro Pro Gly Arg Arg Glu Pro Leu Arg Ser Leu
             495                 500                 505

 cgc atc ctg cac agc gcc cgc gcg ctc ttc gtg ggg ctg aga gac ggc     1885
 Arg Ile Leu His Ser Ala Arg Ala Leu Phe Val Gly Leu Arg Asp Gly
         510                 515                 520

 gtc ctg cgg gtc cca ctg gag agg tgc gcc gcc tac cgc agc cag ggg     1933
 Val Leu Arg Val Pro Leu Glu Arg Cys Ala Ala Tyr Arg Ser Gln Gly
     525                 530                 535

 gca tgc ctg ggg gcc cgg gac ccg tac tgt ggc tgg gac ggg aag cag     1981
 Ala Cys Leu Gly Ala Arg Asp Pro Tyr Cys Gly Trp Asp Gly Lys Gln
 540                 545                 550                 555

 caa cgt tgc agc aca ctc gag gac agc tcc aac atg agc ctc tgg acc     2029
 Gln Arg Cys Ser Thr Leu Glu Asp Ser Ser Asn Met Ser Leu Trp Thr
                 560                 565                 570

 cag aac atc acc gcc tgt cct gtg cgg aat gtg aca cgg gat ggg ggc     2077
 Gln Asn Ile Thr Ala Cys Pro Val Arg Asn Val Thr Arg Asp Gly Gly
             575                 580                 585

 ttc ggc cca tgg tca cca tgg caa cca tgt gag cac ttg gat ggg gac     2125
 Phe Gly Pro Trp Ser Pro Trp Gln Pro Cys Glu His Leu Asp Gly Asp
         590                 595                 600

 aac tca ggc tct tgc ctg tgt cga gct cga tcc tgt gat tcc cct cga     2173
 Asn Ser Gly Ser Cys Leu Cys Arg Ala Arg Ser Cys Asp Ser Pro Arg
     605                 610                 615

 ccc cgc tgt ggg ggc ctt gac tgc ctg ggg cca gcc atc cac atc gcc     2221
 Pro Arg Cys Gly Gly Leu Asp Cys Leu Gly Pro Ala Ile His Ile Ala
 620                 625                 630                 635

 aac tgc tcc agg aat ggg gcg tgg acc ccg tgg tca tcg tgg gcg ctg     2269
 Asn Cys Ser Arg Asn Gly Ala Trp Thr Pro Trp Ser Ser Trp Ala Leu
                 640                 645                 650

 tgc agc acg tcc tgt ggc atc ggc ttc cag gtc cgc cag cga agt tgc     2317
 Cys Ser Thr Ser Cys Gly Ile Gly Phe Gln Val Arg Gln Arg Ser Cys
             655                 660                 665

 agc aac cct gct ccc cgc cac ggg ggc cgc atc tgc gtg ggc aag agc     2365
 Ser Asn Pro Ala Pro Arg His Gly Gly Arg Ile Cys Val Gly Lys Ser
         670                 675                 680

 cgg gag gaa cgg ttc tgt aat gag aac acg cct tgc ccg gtg ccc atc     2413
 Arg Glu Glu Arg Phe Cys Asn Glu Asn Thr Pro Cys Pro Val Pro Ile
     685                 690                 695

 ttc tgg gct tcc tgg ggc tcc tgg agc aag tgc agc agc aac tgt gga     2461
 Phe Trp Ala Ser Trp Gly Ser Trp Ser Lys Cys Ser Ser Asn Cys Gly
 700                 705                 710                 715

 ggg ggc atg cag tcg cgg cgt cgg gcc tgc gag aac ggc aac tcc tgc     2509
 Gly Gly Met Gln Ser Arg Arg Arg Ala Cys Glu Asn Gly Asn Ser Cys
                 720                 725                 730

 ctg ggc tgc ggc gtg gag ttc aag acg tgc aac ccc gag ggc tgc ccc     2557
 Leu Gly Cys Gly Val Glu Phe Lys Thr Cys Asn Pro Glu Gly Cys Pro
             735                 740                 745

 gaa gtg cgg cgc aac acc ccc tgg acg ccg tgg ctg ccc gtg aac gtg     2605
 Glu Val Arg Arg Asn Thr Pro Trp Thr Pro Trp Leu Pro Val Asn Val
         750                 755                 760

 acg cag ggc ggg gca cgg cag gag cag cgg ttc cgc ttc acc tgc cgc     2653
 Thr Gln Gly Gly Ala Arg Gln Glu Gln Arg Phe Arg Phe Thr Cys Arg
     765                 770                 775

 gcg ccc ctt gca gac ccg cac ggc ctg cag ttc ggc agg aga agg acc     2701
 Ala Pro Leu Ala Asp Pro His Gly Leu Gln Phe Gly Arg Arg Arg Thr
 780                 785                 790                 795

 gag acg agg acc tgt ccc gcg gac ggc tcc ggc tcc tgc gac acc gac     2749
 Glu Thr Arg Thr Cys Pro Ala Asp Gly Ser Gly Ser Cys Asp Thr Asp
                 800                 805                 810

 gcc ctg gtg gag gac ctc ctg cgc agc ggg agc acc tcc ccg cac acg     2797
 Ala Leu Val Glu Asp Leu Leu Arg Ser Gly Ser Thr Ser Pro His Thr
             815                 820                 825

 gtg agc ggg ggc tgg gcc gcc tgg ggc ccg tgg tcg tcc tgc tcc cgg     2845
 Val Ser Gly Gly Trp Ala Ala Trp Gly Pro Trp Ser Ser Cys Ser Arg
         830                 835                 840

 gac tgc gag ctg ggc ttc cgc gtc cgc aag aga acg tgc act aac ccg     2893
 Asp Cys Glu Leu Gly Phe Arg Val Arg Lys Arg Thr Cys Thr Asn Pro
     845                 850                 855

 gag ccc cgc aac ggg ggc ctg ccc tgc gtg ggc gat gct gcc gag tac     2941
 Glu Pro Arg Asn Gly Gly Leu Pro Cys Val Gly Asp Ala Ala Glu Tyr
 860                 865                 870                 875

 cag gac tgc aac ccc cag gct tgc cca gtt cgg ggt gct tgg tcc tgc     2989
 Gln Asp Cys Asn Pro Gln Ala Cys Pro Val Arg Gly Ala Trp Ser Cys
                 880                 885                 890

 tgg acc tca tgg tct cca tgc tca gct tcc tgt ggt ggg ggt cac tat     3037
 Trp Thr Ser Trp Ser Pro Cys Ser Ala Ser Cys Gly Gly Gly His Tyr
             895                 900                 905

 caa cgc acc cgt tcc tgc acc agc ccc gca ccc tcc cca ggt gag gac     3085
 Gln Arg Thr Arg Ser Cys Thr Ser Pro Ala Pro Ser Pro Gly Glu Asp
         910                 915                 920

 atc tgt ctc ggg ctg cac acg gag gag gca cta tgt gcc aca cag gcc     3133
 Ile Cys Leu Gly Leu His Thr Glu Glu Ala Leu Cys Ala Thr Gln Ala
     925                 930                 935

 tgc cca gaa ggc tgg tcg ccc tgg tct gag tgg agt aag tgc act gac     3181
 Cys Pro Glu Gly Trp Ser Pro Trp Ser Glu Trp Ser Lys Cys Thr Asp
 940                 945                 950                 955

 gac gga gcc cag agc cga agc cgg cac tgt gag gag ctc ctc cca ggg     3229
 Asp Gly Ala Gln Ser Arg Ser Arg His Cys Glu Glu Leu Leu Pro Gly
                 960                 965                 970

 tcc agc gcc tgt gct gga aac agc agc cag agc cgc ccc tgc ccc tac     3277
 Ser Ser Ala Cys Ala Gly Asn Ser Ser Gln Ser Arg Pro Cys Pro Tyr
             975                 980                 985

 agc gag att ccc gtc atc ctg cca gcc tcc agc atg gag gag gcc acc     3325
 Ser Glu Ile Pro Val Ile Leu Pro Ala Ser Ser Met Glu Glu Ala Thr
         990                 995                1000

 ggc tgt gca ggg ttc aat ctc atc cac ttg gtg gcc acg ggc atc tcc     3373
 Gly Cys Ala Gly Phe Asn Leu Ile His Leu Val Ala Thr Gly Ile Ser
    1005                1010                1015

 tgc ttc ttg ggc tct ggg ctc ctg acc cta gca gtg tac ctg tct tgc     3421
 Cys Phe Leu Gly Ser Gly Leu Leu Thr Leu Ala Val Tyr Leu Ser Cys
1020                1025                1030                1035

 cag cac tgc cag cgt cag tcc cag gag tcc aca ctg gtc cat cct gcc     3469
 Gln His Cys Gln Arg Gln Ser Gln Glu Ser Thr Leu Val His Pro Ala
                1040                1045                1050

 acc ccc aac cat ttg cac tac aag ggc gga ggc acc ccg aag aat gaa     3517
 Thr Pro Asn His Leu His Tyr Lys Gly Gly Gly Thr Pro Lys Asn Glu
            1055                1060                1065

 aag tac aca ccc atg gaa ttc aag acc ctg aac aag aat aac ttg atc     3565
 Lys Tyr Thr Pro Met Glu Phe Lys Thr Leu Asn Lys Asn Asn Leu Ile
        1070                1075                1080

 cct gat gac aga gcc aac ttc tac cca ttg cag cag acc aat gtg tac     3613
 Pro Asp Asp Arg Ala Asn Phe Tyr Pro Leu Gln Gln Thr Asn Val Tyr
    1085                1090                1095

 acg act act tac tac cca agc ccc ctg aac aaa cac agc ttc cgg ccc     3661
 Thr Thr Thr Tyr Tyr Pro Ser Pro Leu Asn Lys His Ser Phe Arg Pro
1100                1105                1110                1115

 gag gcc tca cct gga caa cgg tgc ttc ccc aac agc tga taccgccgtc      3710
 Glu Ala Ser Pro Gly Gln Arg Cys Phe Pro Asn Ser 
                1120                1125

 ctggggactt gggcttcttg ccttcataag gcacagagca gatggagatg ggacagtgga   3770

 gccagtttgg ttttctccct ctgcactagg ccaagaactt gctgccttgc ctgtgggggg   3830

 tcccatccgg cttcagagag ctctggctgg cattgaccat gggggaaagg gctggtttca   3890

 ggctgacata tggccgcagg tccagttcag cccaggtctc tcatggttat cttccaaccc   3950

 actgtcacgc tgacactatg ctgccatgcc tgggctgtgg acctactggg catttgagga   4010

 actggagaat ggagatggca agagggcagg cttttaagtt tgggttggag acaacttcct   4070

 gtggccccca caagctgagt ctggccttct ccagctggcc ccaaaaaagg cctttgctac   4130

 atcctgatta tctctgaaag taatcaatca agtggctcca gtagctctgg attttctgcc   4190

 agggctgggc cattgtggtg ctgccccagt atgacatggg accaaggcca gcgcaggtta   4250

 tccacctctg cctggaagtc tatactctac ccagggcatc cctctggtca gaggcagtga   4310

 gtactgggaa ctggaggctg acctgtgctt agaagtcctt taatctgggc tggtacaggc   4370

 ctcagccttg ccctcaatgc acgaaaggtg gcccaggaga gaggatcaat gccacaggag   4430

 gcagaagtct ggcctctgtg cctctatgga gactatcttc cagttgctgc tcaacagagt   4490

 tgttggctga gacctgcttg ggagtctctg ctggcccttc atctgttcag gaacacacac   4550

 acacacacac tcacacacgc acacacaatc acaatttgct acagcaacaa aaaagacatt   4610

 gggctgtggc attattaatt aaagatgata tccagtctcc                         4650




      <210> 527
      <211> 3140
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (1)..(2913)

      <400> 527
  atg aga atg ggc ggc agt aat cat ccc ttc ctc ctg ggg gtg gtt gtg      48
  Met Arg Met Gly Gly Ser Asn His Pro Phe Leu Leu Gly Val Val Val
    1               5                  10                  15

 aag ctt gaa gga gac act gta agc gct cgg gtg gta ccc tgg tac tcc       96
 Lys Leu Glu Gly Asp Thr Val Ser Ala Arg Val Val Pro Trp Tyr Ser
              20                  25                  30

 atc act aac ctg ctg tgt gac ctc agc aac ccc ctg gcc ccc att cct      144
 Ile Thr Asn Leu Leu Cys Asp Leu Ser Asn Pro Leu Ala Pro Ile Pro
          35                  40                  45

 gca gag caa agc cca aat gca tgt ggc agc cat gag gga cta ggg atc      192
 Ala Glu Gln Ser Pro Asn Ala Cys Gly Ser His Glu Gly Leu Gly Ile
      50                  55                  60

 cag atc ccc ctc tcc tgt ctg gcc agt cga aag gac ttc gtg tct cca      240
 Gln Ile Pro Leu Ser Cys Leu Ala Ser Arg Lys Asp Phe Val Ser Pro
  65                  70                  75                  80

 gag gtc cta cta ggt gct gga act gag ctg agc agt gca gac ggg cct      288
 Glu Val Leu Leu Gly Ala Gly Thr Glu Leu Ser Ser Ala Asp Gly Pro
                  85                  90                  95

 ggg gca ggc atg gcg gat tcc agc gaa ggc ccc cgc gcg ggg ccc ggg      336
 Gly Ala Gly Met Ala Asp Ser Ser Glu Gly Pro Arg Ala Gly Pro Gly
             100                 105                 110

 gag gtg gct gag ctc ccc ggg gat gag agt ggc acc cca ggt ggg gag      384
 Glu Val Ala Glu Leu Pro Gly Asp Glu Ser Gly Thr Pro Gly Gly Glu
         115                 120                 125

 gct ttt cct ctc tcc tcc ctg gcc aat ctg ttt gag ggg gag gat ggc      432
 Ala Phe Pro Leu Ser Ser Leu Ala Asn Leu Phe Glu Gly Glu Asp Gly
     130                 135                 140

 tcc ctt tcg ccc tca ccg gct gat gcc agt cgc cct gct ggc cca ggc      480
 Ser Leu Ser Pro Ser Pro Ala Asp Ala Ser Arg Pro Ala Gly Pro Gly
 145                 150                 155                 160

 gat ggg cga cca aat ctg cgc atg aag ttc cag ggc gcc ttc cgc aag      528
 Asp Gly Arg Pro Asn Leu Arg Met Lys Phe Gln Gly Ala Phe Arg Lys
                 165                 170                 175

 ggg gtg ccc aac ccc atc gat ctg ctg gag tcc acc cta tat gag tcc      576
 Gly Val Pro Asn Pro Ile Asp Leu Leu Glu Ser Thr Leu Tyr Glu Ser
             180                 185                 190

 tcg gtg gtg cct ggg ccc aag aaa gca ccc atg gac tca ctg ttt gac      624
 Ser Val Val Pro Gly Pro Lys Lys Ala Pro Met Asp Ser Leu Phe Asp
         195                 200                 205

 tac ggc acc tat cgt cac cac tcc agt gac aac aag agg tgg agg aag      672
 Tyr Gly Thr Tyr Arg His His Ser Ser Asp Asn Lys Arg Trp Arg Lys
     210                 215                 220

 aag atc ata gag aag cag ccg cag agc ccc aaa gct ccc gcc cct cag      720
 Lys Ile Ile Glu Lys Gln Pro Gln Ser Pro Lys Ala Pro Ala Pro Gln
 225                 230                 235                 240

 ccg ccc ccc atc ctc aaa gtc ttc aac cgg ccc atc ctc ttt gac atc      768
 Pro Pro Pro Ile Leu Lys Val Phe Asn Arg Pro Ile Leu Phe Asp Ile
                 245                 250                 255

 gtg tcc cgg ggc tcc act gct gac ctg gac ggg ctg ctc cca ttc ttg      816
 Val Ser Arg Gly Ser Thr Ala Asp Leu Asp Gly Leu Leu Pro Phe Leu
             260                 265                 270

 ctg acc cac aag aaa cgc cta act gat gag gag ttt cgg gaa cca tct      864
 Leu Thr His Lys Lys Arg Leu Thr Asp Glu Glu Phe Arg Glu Pro Ser
         275                 280                 285

 acg ggg aag acc tgc ctg ccc aag gcc ttg ctg aac ctg agc aat ggc      912
 Thr Gly Lys Thr Cys Leu Pro Lys Ala Leu Leu Asn Leu Ser Asn Gly
     290                 295                 300

 cgc aac gac acc atc cct gtg ctg ctg gac atc gcg gag cgc acc ggc      960
 Arg Asn Asp Thr Ile Pro Val Leu Leu Asp Ile Ala Glu Arg Thr Gly
 305                 310                 315                 320

 aac atg agg gag ttc att aac tcg ccc ttc cgt gac atc tac tat cga     1008
 Asn Met Arg Glu Phe Ile Asn Ser Pro Phe Arg Asp Ile Tyr Tyr Arg
                 325                 330                 335

 ggg cag aca gcc ctg cac atc gcc att gag cgt cgc tgc aaa cac tac     1056
 Gly Gln Thr Ala Leu His Ile Ala Ile Glu Arg Arg Cys Lys His Tyr
             340                 345                 350

 gtg gaa ctt ctc gtg gcc cag gga gct gat gtc cac gcc cag gcc cgt     1104
 Val Glu Leu Leu Val Ala Gln Gly Ala Asp Val His Ala Gln Ala Arg
         355                 360                 365

 ggg cgc ttc ttc cag ccc aag gat gag ggg ggc tac ttc tac ttt ggg     1152
 Gly Arg Phe Phe Gln Pro Lys Asp Glu Gly Gly Tyr Phe Tyr Phe Gly
     370                 375                 380

 gag ctg ccc ctg tcg ctg gct gcc tgc acc aac cag ccc cac att gtc     1200
 Glu Leu Pro Leu Ser Leu Ala Ala Cys Thr Asn Gln Pro His Ile Val
 385                 390                 395                 400

 aac tac ctg acg gag aac ccc cac aag aag gcg gac atg cgg cgc cag     1248
 Asn Tyr Leu Thr Glu Asn Pro His Lys Lys Ala Asp Met Arg Arg Gln
                 405                 410                 415

 gac tcg cga ggc aac aca gtg ctg cat gcg ctg gtg gcc att gct gac     1296
 Asp Ser Arg Gly Asn Thr Val Leu His Ala Leu Val Ala Ile Ala Asp
             420                 425                 430

 aac acc cgt gag aac acc aag ttt gtt acc aag atg tac gac ctg ctg     1344
 Asn Thr Arg Glu Asn Thr Lys Phe Val Thr Lys Met Tyr Asp Leu Leu
         435                 440                 445

 ctg ctc aag tgt gcc cgc ctc ttc ccc gac agc aac ctg gag gcc gtg     1392
 Leu Leu Lys Cys Ala Arg Leu Phe Pro Asp Ser Asn Leu Glu Ala Val
     450                 455                 460

 ctc aac aac gac ggc ctc tcg ccc ctc atg atg gct gcc aag acg ggc     1440
 Leu Asn Asn Asp Gly Leu Ser Pro Leu Met Met Ala Ala Lys Thr Gly
 465                 470                 475                 480

 aag att ggg gtc ttt cag cac atc atc cgg cgg gag gtg acg gat gag     1488
 Lys Ile Gly Val Phe Gln His Ile Ile Arg Arg Glu Val Thr Asp Glu
                 485                 490                 495

 gac aca cgg cac ctg tcc cgc aag ttc aag gac tgg gcc tat ggg cca     1536
 Asp Thr Arg His Leu Ser Arg Lys Phe Lys Asp Trp Ala Tyr Gly Pro
             500                 505                 510

 gtg tat tcc tcg ctt tat gac ctc tcc tcc ctg gac acg tgt ggg gaa     1584
 Val Tyr Ser Ser Leu Tyr Asp Leu Ser Ser Leu Asp Thr Cys Gly Glu
         515                 520                 525

 gag gcc tcc gtg ctg gag atc ctg gtg tac aac agc aag att gag aac     1632
 Glu Ala Ser Val Leu Glu Ile Leu Val Tyr Asn Ser Lys Ile Glu Asn
     530                 535                 540

 cgc cac gag atg ctg gct gtg gag ccc atc aat gaa ctg ctg cgg gac     1680
 Arg His Glu Met Leu Ala Val Glu Pro Ile Asn Glu Leu Leu Arg Asp
 545                 550                 555                 560

 aag tgg cgc aag ttc ggg gcc gtc tcc ttc tac atc aac gtg gtc tcc     1728
 Lys Trp Arg Lys Phe Gly Ala Val Ser Phe Tyr Ile Asn Val Val Ser
                 565                 570                 575

 tac ctg tgt gcc atg gtc atc ttc act ctc acc gcc tac tac cag ccg     1776
 Tyr Leu Cys Ala Met Val Ile Phe Thr Leu Thr Ala Tyr Tyr Gln Pro
             580                 585                 590

 ctg gag ggc aca ccg ccg tac cct tac cgc acc acg gtg gac tac ctg     1824
 Leu Glu Gly Thr Pro Pro Tyr Pro Tyr Arg Thr Thr Val Asp Tyr Leu
         595                 600                 605

 cgg ctg gct ggc gag gtc att acg ctc ttc act ggg gtc ctg ttc ttc     1872
 Arg Leu Ala Gly Glu Val Ile Thr Leu Phe Thr Gly Val Leu Phe Phe
     610                 615                 620

 ttc acc aac atc aaa gac ttg ttc atg aag aaa tgc cct gga gtg aat     1920
 Phe Thr Asn Ile Lys Asp Leu Phe Met Lys Lys Cys Pro Gly Val Asn
 625                 630                 635                 640

 tct ctc ttc att gat ggc tcc ttc cag ctg ctc tac ttc atc tac tct     1968
 Ser Leu Phe Ile Asp Gly Ser Phe Gln Leu Leu Tyr Phe Ile Tyr Ser
                 645                 650                 655

 gtc ctg gtg atc gtc tca gca gcc ctc tac ctg gca ggg atc gag gcc     2016
 Val Leu Val Ile Val Ser Ala Ala Leu Tyr Leu Ala Gly Ile Glu Ala
             660                 665                 670

 tac ctg gcc gtg atg gtc ttt gcc ctg gtc ctg ggc tgg atg aat gcc     2064
 Tyr Leu Ala Val Met Val Phe Ala Leu Val Leu Gly Trp Met Asn Ala
         675                 680                 685

 ctt tac ttc acc cgt ggg ctg aag ctg acg ggg acc tat agc atc atg     2112
 Leu Tyr Phe Thr Arg Gly Leu Lys Leu Thr Gly Thr Tyr Ser Ile Met
     690                 695                 700

 atc cag aag att ctc ttc aag gac ctt ttc cga ttc ctg ctc gtc tac     2160
 Ile Gln Lys Ile Leu Phe Lys Asp Leu Phe Arg Phe Leu Leu Val Tyr
 705                 710                 715                 720

 ttg ctc ttc atg atc ggc tac gcc tca gcc ctg gtc tcc ctc ctg aac     2208
 Leu Leu Phe Met Ile Gly Tyr Ala Ser Ala Leu Val Ser Leu Leu Asn
                 725                 730                 735

 ccg tgt gcc aac atg aag gtg tgc aat gag gac cag acc aac tgc aca     2256
 Pro Cys Ala Asn Met Lys Val Cys Asn Glu Asp Gln Thr Asn Cys Thr
             740                 745                 750

 gtg ccc act tac ccc tcg tgc cgt gac agc gag acc ttc agc acc ttc     2304
 Val Pro Thr Tyr Pro Ser Cys Arg Asp Ser Glu Thr Phe Ser Thr Phe
         755                 760                 765

 ctc ctg gac ctg ttt aag ctg acc atc ggc atg ggc gac ctg gag atg     2352
 Leu Leu Asp Leu Phe Lys Leu Thr Ile Gly Met Gly Asp Leu Glu Met
     770                 775                 780

 ctg agc agc acc aag tac ccc gtg gtc ttc atc atc ctg ctg gtg acc     2400
 Leu Ser Ser Thr Lys Tyr Pro Val Val Phe Ile Ile Leu Leu Val Thr
 785                 790                 795                 800

 tac atc atc ctc acc ttt gtg ctg ctc ctc aac atg ctc att gcc ctc     2448
 Tyr Ile Ile Leu Thr Phe Val Leu Leu Leu Asn Met Leu Ile Ala Leu
                 805                 810                 815

 atg ggc gag aca gtg ggc cag gtc tcc aag gag agc aag cac atc tgg     2496
 Met Gly Glu Thr Val Gly Gln Val Ser Lys Glu Ser Lys His Ile Trp
             820                 825                 830

 aag ctg cag tgg gcc acc acc atc ctg gac att gag cgc tcc ttc ccc     2544
 Lys Leu Gln Trp Ala Thr Thr Ile Leu Asp Ile Glu Arg Ser Phe Pro
         835                 840                 845

 gta ttc ctg agg aag gcc ttc cgc tct ggg gag atg gtc acc gtg ggc     2592
 Val Phe Leu Arg Lys Ala Phe Arg Ser Gly Glu Met Val Thr Val Gly
     850                 855                 860

 aag agc tcg gac ggc act cct gac cgc agg tgg tgc ttc agg gtg aat     2640
 Lys Ser Ser Asp Gly Thr Pro Asp Arg Arg Trp Cys Phe Arg Val Asn
 865                 870                 875                 880

 gag gtg aac tgg tct cac tgg aac cag aac ttg ggc atc atc aac gag     2688
 Glu Val Asn Trp Ser His Trp Asn Gln Asn Leu Gly Ile Ile Asn Glu
                 885                 890                 895

 gac ccg ggc aag aat gag acc tac cag tat tat ggc ttc tcg cat acc     2736
 Asp Pro Gly Lys Asn Glu Thr Tyr Gln Tyr Tyr Gly Phe Ser His Thr
             900                 905                 910

 gtg ggc cgc ctc cgc agg gat cgc tgg tcc tcg gtg gta ccc cgc gtg     2784
 Val Gly Arg Leu Arg Arg Asp Arg Trp Ser Ser Val Val Pro Arg Val
         915                 920                 925

 gtg gaa ctg aac aag aac tcg aac ccg gac gag gtg gtg gtg cct ctg     2832
 Val Glu Leu Asn Lys Asn Ser Asn Pro Asp Glu Val Val Val Pro Leu
     930                 935                 940

 gac agc atg ggg aac ccc cgc tgc gat ggc cac cag cag ggt tac ccc     2880
 Asp Ser Met Gly Asn Pro Arg Cys Asp Gly His Gln Gln Gly Tyr Pro
 945                 950                 955                 960

 cgc aag tgg agg act gat gac gcc ccg ctc tag ggactgca gcccagcccc     2931
 Arg Lys Trp Arg Thr Asp Asp Ala Pro Leu 
                 965                 970

 agcttctctg cccactcatt tctagtccag ccgcatttca gcagtgcctt ctggggtgtc   2991

 cccccacacc ctgctttggc cccagaggcg agggaccagt ggaggtgcca gggaggcccc   3051

 aggaccctgt ggtcccctgg ctctgcctcc ccaccctggg gtgggggctc ccggccacct   3111

 gtcttgctcc tatggagtca cataagcca                                     3140




      <210> 528
      <211> 3383
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (1)..(3156)

      <400> 528
  atg aga atg ggc ggc agt aat cat ccc ttc ctc ctg ggg gtg gtt gtg      48
  Met Arg Met Gly Gly Ser Asn His Pro Phe Leu Leu Gly Val Val Val
    1               5                  10                  15

 aag ctt gaa gga gac act gta agc gct cgg gtg gta ccc tgg tac tcc       96
 Lys Leu Glu Gly Asp Thr Val Ser Ala Arg Val Val Pro Trp Tyr Ser
              20                  25                  30

 atc act aac ctg ctg tgt gac ctc agc aac ccc ctg gcc ccc att cct      144
 Ile Thr Asn Leu Leu Cys Asp Leu Ser Asn Pro Leu Ala Pro Ile Pro
          35                  40                  45

 gca gag caa agc cca aat gca tgt ggc agc cat gag gga cta ggg atc      192
 Ala Glu Gln Ser Pro Asn Ala Cys Gly Ser His Glu Gly Leu Gly Ile
      50                  55                  60

 cag atc ccc ctc tcc tgt ctg gcc agt cga aag gac ttc gtg tct cca      240
 Gln Ile Pro Leu Ser Cys Leu Ala Ser Arg Lys Asp Phe Val Ser Pro
  65                  70                  75                  80

 gag gtc cta cta ggt gct gga act gag ctg agc agt gca gac ggg cct      288
 Glu Val Leu Leu Gly Ala Gly Thr Glu Leu Ser Ser Ala Asp Gly Pro
                  85                  90                  95

 ggg gca ggc atg gcg gat tcc agc gaa ggc ccc cgc gcg ggg ccc ggg      336
 Gly Ala Gly Met Ala Asp Ser Ser Glu Gly Pro Arg Ala Gly Pro Gly
             100                 105                 110

 gag gtg gct gag ctc ccc ggg gat gag agt ggc acc cca ggt ggg gag      384
 Glu Val Ala Glu Leu Pro Gly Asp Glu Ser Gly Thr Pro Gly Gly Glu
         115                 120                 125

 gct ttt cct ctc tcc tcc ctg gcc aat ctg ttt gag ggg gag gat ggc      432
 Ala Phe Pro Leu Ser Ser Leu Ala Asn Leu Phe Glu Gly Glu Asp Gly
     130                 135                 140

 tcc ctt tcg ccc tca ccg gct gat gcc agt cgc cct gct ggc cca ggc      480
 Ser Leu Ser Pro Ser Pro Ala Asp Ala Ser Arg Pro Ala Gly Pro Gly
 145                 150                 155                 160

 gat ggg cga cca aat ctg cgc atg aag ttc cag ggc gcc ttc cgc aag      528
 Asp Gly Arg Pro Asn Leu Arg Met Lys Phe Gln Gly Ala Phe Arg Lys
                 165                 170                 175

 ggg gtg ccc aac ccc atc gat ctg ctg gag tcc acc cta tat gag tcc      576
 Gly Val Pro Asn Pro Ile Asp Leu Leu Glu Ser Thr Leu Tyr Glu Ser
             180                 185                 190

 tcg gtg gtg cct ggg ccc aag aaa gca ccc atg gac tca ctg ttt gac      624
 Ser Val Val Pro Gly Pro Lys Lys Ala Pro Met Asp Ser Leu Phe Asp
         195                 200                 205

 tac ggc acc tat cgt cac cac tcc agt gac aac aag agg tgg agg aag      672
 Tyr Gly Thr Tyr Arg His His Ser Ser Asp Asn Lys Arg Trp Arg Lys
     210                 215                 220

 aag atc ata gag aag cag ccg cag agc ccc aaa gct ccc gcc cct cag      720
 Lys Ile Ile Glu Lys Gln Pro Gln Ser Pro Lys Ala Pro Ala Pro Gln
 225                 230                 235                 240

 ccg ccc ccc atc ctc aaa gtc ttc aac cgg ccc atc ctc ttt gac atc      768
 Pro Pro Pro Ile Leu Lys Val Phe Asn Arg Pro Ile Leu Phe Asp Ile
                 245                 250                 255

 gtg tcc cgg ggc tcc act gct gac ctg gac ggg ctg ctc cca ttc ttg      816
 Val Ser Arg Gly Ser Thr Ala Asp Leu Asp Gly Leu Leu Pro Phe Leu
             260                 265                 270

 ctg acc cac aag aaa cgc cta act gat gag gag ttt cgg gaa cca tct      864
 Leu Thr His Lys Lys Arg Leu Thr Asp Glu Glu Phe Arg Glu Pro Ser
         275                 280                 285

 acg ggg aag acc tgc ctg ccc aag gcc ttg ctg aac ctg agc aat ggc      912
 Thr Gly Lys Thr Cys Leu Pro Lys Ala Leu Leu Asn Leu Ser Asn Gly
     290                 295                 300

 cgc aac gac acc atc cct gtg ctg ctg gac atc gcg gag cgc acc ggc      960
 Arg Asn Asp Thr Ile Pro Val Leu Leu Asp Ile Ala Glu Arg Thr Gly
 305                 310                 315                 320

 aac atg agg gag ttc att aac tcg ccc ttc cgt gac atc tac tat cga     1008
 Asn Met Arg Glu Phe Ile Asn Ser Pro Phe Arg Asp Ile Tyr Tyr Arg
                 325                 330                 335

 ggt ggg gcc ccg ggc tgg gca ggg gtg cca cgg ggg ctg atg gag acg     1056
 Gly Gly Ala Pro Gly Trp Ala Gly Val Pro Arg Gly Leu Met Glu Thr
             340                 345                 350

 ctg tcc ttt gct tgt ctg act cct gag act ttt gat ctg ggc cta agt     1104
 Leu Ser Phe Ala Cys Leu Thr Pro Glu Thr Phe Asp Leu Gly Leu Ser
         355                 360                 365

 gcc agc atg tac cca gga cct gac aaa tgg atg gat gga tgg atg gat     1152
 Ala Ser Met Tyr Pro Gly Pro Asp Lys Trp Met Asp Gly Trp Met Asp
     370                 375                 380

 gga tgg atg cat gga tgc atg gat aga tgg atg gat gaa gga acg caa     1200
 Gly Trp Met His Gly Cys Met Asp Arg Trp Met Asp Glu Gly Thr Gln
 385                 390                 395                 400

 gcc tgg cta ggt ctc tgc tcc gcc agg acc ctg gat gac cgt ccc ctg     1248
 Ala Trp Leu Gly Leu Cys Ser Ala Arg Thr Leu Asp Asp Arg Pro Leu
                 405                 410                 415

 ccc cca cag aca gcc ctg cac atc gcc att gag cgt cgc tgc aaa cac     1296
 Pro Pro Gln Thr Ala Leu His Ile Ala Ile Glu Arg Arg Cys Lys His
             420                 425                 430

 tac gtg gaa ctt ctc gtg gcc cag gga gct gat gtc cac gcc cag gcc     1344
 Tyr Val Glu Leu Leu Val Ala Gln Gly Ala Asp Val His Ala Gln Ala
         435                 440                 445

 cgt ggg cgc ttc ttc cag ccc aag gat gag ggg ggc tac ttc tac ttt     1392
 Arg Gly Arg Phe Phe Gln Pro Lys Asp Glu Gly Gly Tyr Phe Tyr Phe
     450                 455                 460

 ggg gag ctg ccc ctg tcg ctg gct gcc tgc acc aac cag ccc cac att     1440
 Gly Glu Leu Pro Leu Ser Leu Ala Ala Cys Thr Asn Gln Pro His Ile
 465                 470                 475                 480

 gtc aac tac ctg acg gag aac ccc cac aag aag gcg gac atg cgg cgc     1488
 Val Asn Tyr Leu Thr Glu Asn Pro His Lys Lys Ala Asp Met Arg Arg
                 485                 490                 495

 cag gac tcg cga ggc aac aca gtg ctg cat gcg ctg gtg gcc att gct     1536
 Gln Asp Ser Arg Gly Asn Thr Val Leu His Ala Leu Val Ala Ile Ala
             500                 505                 510

 gac aac acc cgt gag aac acc aag ttt gtt acc aag atg tac gac ctg     1584
 Asp Asn Thr Arg Glu Asn Thr Lys Phe Val Thr Lys Met Tyr Asp Leu
         515                 520                 525

 ctg ctg ctc aag tgt gcc cgc ctc ttc ccc gac agc aac ctg gag gcc     1632
 Leu Leu Leu Lys Cys Ala Arg Leu Phe Pro Asp Ser Asn Leu Glu Ala
     530                 535                 540

 gtg ctc aac aac gac ggc ctc tcg ccc ctc atg atg gct gcc aag acg     1680
 Val Leu Asn Asn Asp Gly Leu Ser Pro Leu Met Met Ala Ala Lys Thr
 545                 550                 555                 560

 ggc aag att ggg gtc ttt cag cac atc atc cgg cgg gag gtg acg gat     1728
 Gly Lys Ile Gly Val Phe Gln His Ile Ile Arg Arg Glu Val Thr Asp
                 565                 570                 575

 gag gac aca cgg cac ctg tcc cgc aag ttc aag gac tgg gcc tat ggg     1776
 Glu Asp Thr Arg His Leu Ser Arg Lys Phe Lys Asp Trp Ala Tyr Gly
             580                 585                 590

 cca gtg tat tcc tcg ctt tat gac ctc tcc tcc ctg gac acg tgt ggg     1824
 Pro Val Tyr Ser Ser Leu Tyr Asp Leu Ser Ser Leu Asp Thr Cys Gly
         595                 600                 605

 gaa gag gcc tcc gtg ctg gag atc ctg gtg tac aac agc aag att gag     1872
 Glu Glu Ala Ser Val Leu Glu Ile Leu Val Tyr Asn Ser Lys Ile Glu
     610                 615                 620

 aac cgc cac gag atg ctg gct gtg gag ccc atc aat gaa ctg ctg cgg     1920
 Asn Arg His Glu Met Leu Ala Val Glu Pro Ile Asn Glu Leu Leu Arg
 625                 630                 635                 640

 gac aag tgg cgc aag ttc ggg gcc gtc tcc ttc tac atc aac gtg gtc     1968
 Asp Lys Trp Arg Lys Phe Gly Ala Val Ser Phe Tyr Ile Asn Val Val
                 645                 650                 655

 tcc tac ctg tgt gcc atg gtc atc ttc act ctc acc gcc tac tac cag     2016
 Ser Tyr Leu Cys Ala Met Val Ile Phe Thr Leu Thr Ala Tyr Tyr Gln
             660                 665                 670

 ccg ctg gag ggc aca ccg ccg tac cct tac cgc acc acg gtg gac tac     2064
 Pro Leu Glu Gly Thr Pro Pro Tyr Pro Tyr Arg Thr Thr Val Asp Tyr
         675                 680                 685

 ctg cgg ctg gct ggc gag gtc att acg ctc ttc act ggg gtc ctg ttc     2112
 Leu Arg Leu Ala Gly Glu Val Ile Thr Leu Phe Thr Gly Val Leu Phe
     690                 695                 700

 ttc ttc acc aac atc aaa gac ttg ttc atg aag aaa tgc cct gga gtg     2160
 Phe Phe Thr Asn Ile Lys Asp Leu Phe Met Lys Lys Cys Pro Gly Val
 705                 710                 715                 720

 aat tct ctc ttc att gat ggc tcc ttc cag ctg ctc tac ttc atc tac     2208
 Asn Ser Leu Phe Ile Asp Gly Ser Phe Gln Leu Leu Tyr Phe Ile Tyr
                 725                 730                 735

 tct gtc ctg gtg atc gtc tca gca gcc ctc tac ctg gca ggg atc gag     2256
 Ser Val Leu Val Ile Val Ser Ala Ala Leu Tyr Leu Ala Gly Ile Glu
             740                 745                 750

 gcc tac ctg gcc gtg atg gtc ttt gcc ctg gtc ctg ggc tgg atg aat     2304
 Ala Tyr Leu Ala Val Met Val Phe Ala Leu Val Leu Gly Trp Met Asn
         755                 760                 765

 gcc ctt tac ttc acc cgt ggg ctg aag ctg acg ggg acc tat agc atc     2352
 Ala Leu Tyr Phe Thr Arg Gly Leu Lys Leu Thr Gly Thr Tyr Ser Ile
     770                 775                 780

 atg atc cag aag att ctc ttc aag gac ctt ttc cga ttc ctg ctc gtc     2400
 Met Ile Gln Lys Ile Leu Phe Lys Asp Leu Phe Arg Phe Leu Leu Val
 785                 790                 795                 800

 tac ttg ctc ttc atg atc ggc tac gcc tca gcc ctg gtc tcc ctc ctg     2448
 Tyr Leu Leu Phe Met Ile Gly Tyr Ala Ser Ala Leu Val Ser Leu Leu
                 805                 810                 815

 aac ccg tgt gcc aac atg aag gtg tgc aat gag gac cag acc aac tgc     2496
 Asn Pro Cys Ala Asn Met Lys Val Cys Asn Glu Asp Gln Thr Asn Cys
             820                 825                 830

 aca gtg ccc act tac ccc tcg tgc cgt gac agc gag acc ttc agc acc     2544
 Thr Val Pro Thr Tyr Pro Ser Cys Arg Asp Ser Glu Thr Phe Ser Thr
         835                 840                 845

 ttc ctc ctg gac ctg ttt aag ctg acc atc ggc atg ggc gac ctg gag     2592
 Phe Leu Leu Asp Leu Phe Lys Leu Thr Ile Gly Met Gly Asp Leu Glu
     850                 855                 860

 atg ctg agc agc acc aag tac ccc gtg gtc ttc atc atc ctg ctg gtg     2640
 Met Leu Ser Ser Thr Lys Tyr Pro Val Val Phe Ile Ile Leu Leu Val
 865                 870                 875                 880

 acc tac atc atc ctc acc ttt gtg ctg ctc ctc aac atg ctc att gcc     2688
 Thr Tyr Ile Ile Leu Thr Phe Val Leu Leu Leu Asn Met Leu Ile Ala
                 885                 890                 895

 ctc atg ggc gag aca gtg ggc cag gtc tcc aag gag agc aag cac atc     2736
 Leu Met Gly Glu Thr Val Gly Gln Val Ser Lys Glu Ser Lys His Ile
             900                 905                 910

 tgg aag ctg cag tgg gcc acc acc atc ctg gac att gag cgc tcc ttc     2784
 Trp Lys Leu Gln Trp Ala Thr Thr Ile Leu Asp Ile Glu Arg Ser Phe
         915                 920                 925

 ccc gta ttc ctg agg aag gcc ttc cgc tct ggg gag atg gtc acc gtg     2832
 Pro Val Phe Leu Arg Lys Ala Phe Arg Ser Gly Glu Met Val Thr Val
     930                 935                 940

 ggc aag agc tcg gac ggc act cct gac cgc agg tgg tgc ttc agg gtg     2880
 Gly Lys Ser Ser Asp Gly Thr Pro Asp Arg Arg Trp Cys Phe Arg Val
 945                 950                 955                 960

 aat gag gtg aac tgg tct cac tgg aac cag aac ttg ggc atc atc aac     2928
 Asn Glu Val Asn Trp Ser His Trp Asn Gln Asn Leu Gly Ile Ile Asn
                 965                 970                 975

 gag gac ccg ggc aag aat gag acc tac cag tat tat ggc ttc tcg cat     2976
 Glu Asp Pro Gly Lys Asn Glu Thr Tyr Gln Tyr Tyr Gly Phe Ser His
             980                 985                 990

 acc gtg ggc cgc ctc cgc agg gat cgc tgg tcc tcg gtg gta ccc cgc     3024
 Thr Val Gly Arg Leu Arg Arg Asp Arg Trp Ser Ser Val Val Pro Arg
         995                1000                1005

 gtg gtg gaa ctg aac aag aac tcg aac ccg gac gag gtg gtg gtg cct     3072
 Val Val Glu Leu Asn Lys Asn Ser Asn Pro Asp Glu Val Val Val Pro
    1010                1015                1020

 ctg gac agc atg ggg aac ccc cgc tgc gat ggc cac cag cag ggt tac     3120
 Leu Asp Ser Met Gly Asn Pro Arg Cys Asp Gly His Gln Gln Gly Tyr
1025                1030                1035                1040

 ccc cgc aag tgg agg act gat gac gcc ccg ctc tag ggac tgcagcccag     3170
 Pro Arg Lys Trp Arg Thr Asp Asp Ala Pro Leu 
                1045                1050

 ccccagcttc tctgcccact catttctagt ccagccgcat ttcagcagtg ccttctgggg   3230

 tgtcccccca caccctgctt tggccccaga ggcgagggac cagtggaggt gccagggagg   3290

 ccccaggacc ctgtggtccc ctggctctgc ctccccaccc tggggtgggg gctcccggcc   3350

 acctgtcttg ctcctatgga gtcacataag cca                                3383




      <210> 529
      <211> 447
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (1)..(447)

      <400> 529
  atg cag ctg gag tgc ttc aac tta cat att tat gat gat gtg ggg tac      48
  Met Gln Leu Glu Cys Phe Asn Leu His Ile Tyr Asp Asp Val Gly Tyr
    1               5                  10                  15

 ggc cgc tat ctc ctg ttt ctt caa gca gtc tct cta ttc ctg ctc gat       96
 Gly Arg Tyr Leu Leu Phe Leu Gln Ala Val Ser Leu Phe Leu Leu Asp
              20                  25                  30

 atc ttg ccg ctg gag caa agt gac aag gtt tat gaa gtt tac aaa atc      144
 Ile Leu Pro Leu Glu Gln Ser Asp Lys Val Tyr Glu Val Tyr Lys Ile
          35                  40                  45

 tac ata ttt tct ctc ttt ctg gga tat tta ctg cag ttt ggg aat cca      192
 Tyr Ile Phe Ser Leu Phe Leu Gly Tyr Leu Leu Gln Phe Gly Asn Pro
      50                  55                  60

 gct gta ctg gtg ttt cct ttg tta agt tta cta gca gcc tta atg att      240
 Ala Val Leu Val Phe Pro Leu Leu Ser Leu Leu Ala Ala Leu Met Ile
  65                  70                  75                  80

 gct aag tgc ctt cag ctg aat gcg aag aaa gaa act ttt gta gct aaa      288
 Ala Lys Cys Leu Gln Leu Asn Ala Lys Lys Glu Thr Phe Val Ala Lys
                  85                  90                  95

 aca atg aaa gtg att aat ttt tac ttg gtg cgt act ctg aca gtg aca      336
 Thr Met Lys Val Ile Asn Phe Tyr Leu Val Arg Thr Leu Thr Val Thr
             100                 105                 110

 ttg aat att ata atg aag atg ttt gtc cag cac aaa gaa aat ggg cgc      384
 Leu Asn Ile Ile Met Lys Met Phe Val Gln His Lys Glu Asn Gly Arg
         115                 120                 125

 atg ctc aaa ttc ctt gaa gta aaa ttt gga cta aat atg act aag aat      432
 Met Leu Lys Phe Leu Glu Val Lys Phe Gly Leu Asn Met Thr Lys Asn
     130                 135                 140

 ttt aca gtt att tag                                                  447
 Phe Thr Val Ile 
 145





      <210> 530
      <211> 1008
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (199)..(954)

      <400> 530
 ggtagagact tggcttcggg cccttctagc ttgggggtcc cgggaaggag ctgggaggac     60

 ctaggcggcc gttccgcgga gcccggccga ggaggtccct atgttaacta cttgagacaa    120

 aaataaatat ggccttctac agttataatt cagttctggc tattgctcga acaagattcc    180

 catttaaata agacatgt  atg aag aac tat gag agc aag aag tac tcg gat     231
                      Met Lys Asn Tyr Glu Ser Lys Lys Tyr Ser Asp
                        1               5                  10

 cct agt cag cca ggc aat aca gta ctt cac cca gga act aga cta ata      279
 Pro Ser Gln Pro Gly Asn Thr Val Leu His Pro Gly Thr Arg Leu Ile
              15                  20                  25

 caa aag cta cac aca tcc act tgc tgg ctg caa gaa gtt cct ggc aaa      327
 Gln Lys Leu His Thr Ser Thr Cys Trp Leu Gln Glu Val Pro Gly Lys
          30                  35                  40

 cct cag ctg gag caa gcc aca aaa cat cca cag gtg aca agc cct cag      375
 Pro Gln Leu Glu Gln Ala Thr Lys His Pro Gln Val Thr Ser Pro Gln
      45                  50                  55

 gcc aca aaa gaa act ggc atg gag att aaa gaa ggc aag caa tct tat      423
 Ala Thr Lys Glu Thr Gly Met Glu Ile Lys Glu Gly Lys Gln Ser Tyr
  60                  65                  70                  75

 aga caa aaa atc atg gat gaa cta aaa tat tat tac aat gga ttc tac      471
 Arg Gln Lys Ile Met Asp Glu Leu Lys Tyr Tyr Tyr Asn Gly Phe Tyr
                  80                  85                  90

 tta ctt tgg att gac gcc aaa gtt gct gcc aga atg gtt tgg agg ctg      519
 Leu Leu Trp Ile Asp Ala Lys Val Ala Ala Arg Met Val Trp Arg Leu
              95                 100                 105

 ttg cat gga cag gtc ctg acc aga cga gag aga cga agg ctg ttg aga      567
 Leu His Gly Gln Val Leu Thr Arg Arg Glu Arg Arg Arg Leu Leu Arg
         110                 115                 120

 act tgt gtt gat ttc ttc cgc ctg gtt cca ttt atg gtg ttc tta att      615
 Thr Cys Val Asp Phe Phe Arg Leu Val Pro Phe Met Val Phe Leu Ile
     125                 130                 135

 gta ccc ttc atg gaa ttc tta tta cca gtg ttt ctg aaa ctc ttc cca      663
 Val Pro Phe Met Glu Phe Leu Leu Pro Val Phe Leu Lys Leu Phe Pro
 140                 145                 150                 155

 gag atg ttg ccg tca act ttt gaa agt gaa tcc aaa aag gaa gaa aaa      711
 Glu Met Leu Pro Ser Thr Phe Glu Ser Glu Ser Lys Lys Glu Glu Lys
                 160                 165                 170

 cag aaa aag aaa atg gct gta aag ttg gaa cta gca aaa ttt ctt caa      759
 Gln Lys Lys Lys Met Ala Val Lys Leu Glu Leu Ala Lys Phe Leu Gln
             175                 180                 185

 gaa acc atg aca gaa atg gca agg agg aac aga gcc aag atg ggc gat      807
 Glu Thr Met Thr Glu Met Ala Arg Arg Asn Arg Ala Lys Met Gly Asp
         190                 195                 200

 gcc tct aca cag ctc tca tcc tac gtg aag cag gtg tcc atc ttt tat      855
 Ala Ser Thr Gln Leu Ser Ser Tyr Val Lys Gln Val Ser Ile Phe Tyr
     205                 210                 215

 gta atg ccg aac aac ttc ggg gct ggg cgt tct atg aaa aac gca tgt      903
 Val Met Pro Asn Asn Phe Gly Ala Gly Arg Ser Met Lys Asn Ala Cys
 220                 225                 230                 235

 cat cat gga ttt ccc aaa ttg ttc acc atc ttc gga att gca aat atc      951
 His His Gly Phe Pro Lys Leu Phe Thr Ile Phe Gly Ile Ala Asn Ile
                 240                 245                 250

 taa atta tgaacatata atattgtaaa catttaatat tataaacatt gatagtagtt     1008
 






      <210> 531
      <211> 1211
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (71)..(955)

      <400> 531
 ggccgtcccg cgccaggctc gctccgagag ccgcttcctt ctcgccgcgg ccggcgcggg     60

 ccccccggcc   atg cgc ccc cga gcc cca gcc tgc gcc gcc gcg gcg ctc     109
              Met Arg Pro Arg Ala Pro Ala Cys Ala Ala Ala Ala Leu
                1               5                  10

 ggg ctc tgc agc ctt ctg ctg ctg ctc gcg ccc ggg cac gcg tgc ccc      157
 Gly Leu Cys Ser Leu Leu Leu Leu Leu Ala Pro Gly His Ala Cys Pro
      15                  20                  25

 gcg ggc tgc gcc tgc acc gac ccg cac acc gtg gac tgc cgc gac cgc      205
 Ala Gly Cys Ala Cys Thr Asp Pro His Thr Val Asp Cys Arg Asp Arg
  30                  35                  40                  45

 ggg ctg ccc agc gtg cca gac cct ttc ccc ctg gac gtg cgc aag ctg      253
 Gly Leu Pro Ser Val Pro Asp Pro Phe Pro Leu Asp Val Arg Lys Leu
                  50                  55                  60

 ctg gtg gcc ggc aac cgc atc cag cgg atc ccc gag gac ttc ttc atc      301
 Leu Val Ala Gly Asn Arg Ile Gln Arg Ile Pro Glu Asp Phe Phe Ile
              65                  70                  75

 ttc tac ggc gac ctg gtc tac ctg gac ttc agg aac aac tcg ctg cgc      349
 Phe Tyr Gly Asp Leu Val Tyr Leu Asp Phe Arg Asn Asn Ser Leu Arg
          80                  85                  90

 tcg ctg gag gag ggc acg ttc agc ggc tcg gcc aag ctc gtg ttc ctc      397
 Ser Leu Glu Glu Gly Thr Phe Ser Gly Ser Ala Lys Leu Val Phe Leu
      95                 100                 105

 gac ctc agc tac aac aac ttg acc cag ctg ggc gcc ggc gcc ttc cgc      445
 Asp Leu Ser Tyr Asn Asn Leu Thr Gln Leu Gly Ala Gly Ala Phe Arg
 110                 115                 120                 125

 tcg gcc ggg agg ctg gtg aag ctt agc ctg gct aac aac aac ctg gtg      493
 Ser Ala Gly Arg Leu Val Lys Leu Ser Leu Ala Asn Asn Asn Leu Val
                 130                 135                 140

 ggc gtg cac gag gac gcc ttc gag acc ctg gag tcg ctg cag gtg ctg      541
 Gly Val His Glu Asp Ala Phe Glu Thr Leu Glu Ser Leu Gln Val Leu
             145                 150                 155

 gag ctc aac gac aac aac ctg cgc agc ctc agc gtg gcc gcc ctg gcc      589
 Glu Leu Asn Asp Asn Asn Leu Arg Ser Leu Ser Val Ala Ala Leu Ala
         160                 165                 170

 gcg ctg ccc gcg ctg cgc tcc ctg cgt ctg gac ggg aac ccc tgg ctg      637
 Ala Leu Pro Ala Leu Arg Ser Leu Arg Leu Asp Gly Asn Pro Trp Leu
     175                 180                 185

 tgc gac tgt gac ttc gcc cac ctc ttc tcc tgg atc cag gag aac gca      685
 Cys Asp Cys Asp Phe Ala His Leu Phe Ser Trp Ile Gln Glu Asn Ala
 190                 195                 200                 205

 tcc aaa ctg ccc aaa ggc ctt gat gaa atc cag tgc tcc ctg ccc atg      733
 Ser Lys Leu Pro Lys Gly Leu Asp Glu Ile Gln Cys Ser Leu Pro Met
                 210                 215                 220

 gag agc agg agg ata tct ctg cgt gag ctg tcg gag gcc agc ttc agc      781
 Glu Ser Arg Arg Ile Ser Leu Arg Glu Leu Ser Glu Ala Ser Phe Ser
             225                 230                 235

 gag tgt agg ttc agc ctg tca ctc aca gac ctc tgc atc atc att ttc      829
 Glu Cys Arg Phe Ser Leu Ser Leu Thr Asp Leu Cys Ile Ile Ile Phe
         240                 245                 250

 tcc ggt gtg gcc gtg tcc att gcg gcc atc atc tcc agc ttc ttc ctg      877
 Ser Gly Val Ala Val Ser Ile Ala Ala Ile Ile Ser Ser Phe Phe Leu
     255                 260                 265

 gcc act gtg gtg cag tgc ctc cag agg tgc gca ccc aac aaa gat gcg      925
 Ala Thr Val Val Gln Cys Leu Gln Arg Cys Ala Pro Asn Lys Asp Ala
 270                 275                 280                 285

 gag gat gaa gac gag gac aag gat gac tga g ccacctcctc cctcctgcct      976
 Glu Asp Glu Asp Glu Asp Lys Asp Asp 
                 290

 cttactctcc agcaccgaac cagaagctct ctccaagacg gagcgaatgc tgaaccgtgg   1036

 aagcgctggg ccccttctgt ggactgaaca gagccgttcc gggttggccc gcgtaccctg   1096

 gcgggaccct gggtcccaag ttcaacagga aacagaagcc gagggcggcg gagaaattcc   1156

 ggagaaccgc gcaaaagcgg tgagcaggaa catcacacac tccgcacaaa gccag        1211




      <210> 532
      <211> 1544
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (1)..(1494)

      <400> 532
  atg acc ccc aag aaa cca aaa ggt gag atg tct gct tat gcc ttc ttt      48
  Met Thr Pro Lys Lys Pro Lys Gly Glu Met Ser Ala Tyr Ala Phe Phe
    1               5                  10                  15

 atg cag aca tgc aga gaa gaa tgc aag aag aaa aac cca gag gtt ctt       96
 Met Gln Thr Cys Arg Glu Glu Cys Lys Lys Lys Asn Pro Glu Val Leu
              20                  25                  30

 gtc aat ttc aca gaa att tcc aag aag tgc tct gag agg cgg aag aca      144
 Val Asn Phe Thr Glu Ile Ser Lys Lys Cys Ser Glu Arg Arg Lys Thr
          35                  40                  45

 atg tgt gga aaa gag aag tct aag cct gac gaa atg acc gag gtg gat      192
 Met Cys Gly Lys Glu Lys Ser Lys Pro Asp Glu Met Thr Glu Val Asp
      50                  55                  60

 gaa gta ctc tat gat tgg gaa ata aag aat tac gga cca gct aag gga      240
 Glu Val Leu Tyr Asp Trp Glu Ile Lys Asn Tyr Gly Pro Ala Lys Gly
  65                  70                  75                  80

 ggc aag aag aag gac cct aaa gcc ccc aaa agg cta cca tct gga ttc      288
 Gly Lys Lys Lys Asp Pro Lys Ala Pro Lys Arg Leu Pro Ser Gly Phe
                  85                  90                  95

 ttc ctg ttc tgt tca gaa ttc tgc ccc gag gac aaa tcc aca aac cct      336
 Phe Leu Phe Cys Ser Glu Phe Cys Pro Glu Asp Lys Ser Thr Asn Pro
             100                 105                 110

 ggc atc tct att gga gat gtg gca aaa agg ctg agg acc act gga gac      384
 Gly Ile Ser Ile Gly Asp Val Ala Lys Arg Leu Arg Thr Thr Gly Asp
         115                 120                 125

 tgg tct tct gag ggc tgc tcc acg gag gtc aga cct gag ggg acc gtg      432
 Trp Ser Ser Glu Gly Cys Ser Thr Glu Val Arg Pro Glu Gly Thr Val
     130                 135                 140

 tgc tgc tgt gac cac ctg acc ttt ttc gcc ctg ctc ctg aga ccc acc      480
 Cys Cys Cys Asp His Leu Thr Phe Phe Ala Leu Leu Leu Arg Pro Thr
 145                 150                 155                 160

 ttg gac cag tcc acg gtg cat atc ctc aca cgc atc tcc cag gcg ggc      528
 Leu Asp Gln Ser Thr Val His Ile Leu Thr Arg Ile Ser Gln Ala Gly
                 165                 170                 175

 tgt ggg gtc tcc atg atc ttc ctg gcc ttc acc att att ctt tat gcc      576
 Cys Gly Val Ser Met Ile Phe Leu Ala Phe Thr Ile Ile Leu Tyr Ala
             180                 185                 190

 ttt ctg agc cct ggc cta gga cat ggt ccc cat ccc caa caa gcc gag      624
 Phe Leu Ser Pro Gly Leu Gly His Gly Pro His Pro Gln Gln Ala Glu
         195                 200                 205

 tgt gac ttg cca gct ggc cgc att gct gga ccc tgt gag cgg ggc ttg      672
 Cys Asp Leu Pro Ala Gly Arg Ile Ala Gly Pro Cys Glu Arg Gly Leu
     210                 215                 220

 gag cgc cag gag aaa tta cca cca gct ccc cag ggt ggg gcc tgg cat      720
 Glu Arg Gln Glu Lys Leu Pro Pro Ala Pro Gln Gly Gly Ala Trp His
 225                 230                 235                 240

 ctg agg ctt tcc cgg gag agg ttc aag tca gaa gat gcc cca aag atc      768
 Leu Arg Leu Ser Arg Glu Arg Phe Lys Ser Glu Asp Ala Pro Lys Ile
                 245                 250                 255

 cac gtg gcc ctg ggt ggc agc ctg ttc ctc ctg aat ctg gcc ttc ttg      816
 His Val Ala Leu Gly Gly Ser Leu Phe Leu Leu Asn Leu Ala Phe Leu
             260                 265                 270

 gtc aat gtg ggg agt ggc tca aag ggg tct gat gct gcc tgc tgg gcc      864
 Val Asn Val Gly Ser Gly Ser Lys Gly Ser Asp Ala Ala Cys Trp Ala
         275                 280                 285

 cgg ggg gct gtc ttc cac tac ttc ctg ctc tgt gcc ttc acc tgg atg      912
 Arg Gly Ala Val Phe His Tyr Phe Leu Leu Cys Ala Phe Thr Trp Met
     290                 295                 300

 ggc ctt gaa gcc ttc cac ctc tac ctg ctc gct gtc agg gtc ttc aac      960
 Gly Leu Glu Ala Phe His Leu Tyr Leu Leu Ala Val Arg Val Phe Asn
 305                 310                 315                 320

 acc tac ttc ggg cac tac ttc ctg aag ctg agc ctg gtg ggc tgg ggc     1008
 Thr Tyr Phe Gly His Tyr Phe Leu Lys Leu Ser Leu Val Gly Trp Gly
                 325                 330                 335

 ctg ccc gcc ctg atg gtc atc ggc act ggg agt gcc aac agc tac ggc     1056
 Leu Pro Ala Leu Met Val Ile Gly Thr Gly Ser Ala Asn Ser Tyr Gly
             340                 345                 350

 ctc tac acc atc cgt gat agg gag aac cgc acc tct ctg gag cta tgc     1104
 Leu Tyr Thr Ile Arg Asp Arg Glu Asn Arg Thr Ser Leu Glu Leu Cys
         355                 360                 365

 tgg ttc cgt gaa ggg aca acc atg tac gcc ctc tat atc acc gtc cac     1152
 Trp Phe Arg Glu Gly Thr Thr Met Tyr Ala Leu Tyr Ile Thr Val His
     370                 375                 380

 ggc tac ttc ctc atc acc ttc ctc ttt ggc atg gtg gtc ctg gcc ctg     1200
 Gly Tyr Phe Leu Ile Thr Phe Leu Phe Gly Met Val Val Leu Ala Leu
 385                 390                 395                 400

 gtg gtc tgg aag atc ttc acc ctg tcc cgt gct aca gcg gtc aag gag     1248
 Val Val Trp Lys Ile Phe Thr Leu Ser Arg Ala Thr Ala Val Lys Glu
                 405                 410                 415

 cgg ggg aag aac cgg aag aag gtg ctc acc ctg ctg ggc ctc tcg agc     1296
 Arg Gly Lys Asn Arg Lys Lys Val Leu Thr Leu Leu Gly Leu Ser Ser
             420                 425                 430

 ctg gtg ggt gtg aca tgg ggg ttg gcc atc ttc acc ccg ttg ggc ctc     1344
 Leu Val Gly Val Thr Trp Gly Leu Ala Ile Phe Thr Pro Leu Gly Leu
         435                 440                 445

 tcc acc gtc tac atc ttt gca ctt ttc aac tcc ttg caa ggt gtc ttc     1392
 Ser Thr Val Tyr Ile Phe Ala Leu Phe Asn Ser Leu Gln Gly Val Phe
     450                 455                 460

 atc tgc tgc tgg ttc acc atc ctt tac ctc cca agt cag agc acc aca     1440
 Ile Cys Cys Trp Phe Thr Ile Leu Tyr Leu Pro Ser Gln Ser Thr Thr
 465                 470                 475                 480

 gtc tcc tct tct act gca aga ttg gac cag gcc cac tcc gca tct caa     1488
 Val Ser Ser Ser Thr Ala Arg Leu Asp Gln Ala His Ser Ala Ser Gln
                 485                 490                 495

 gaa tag gaaggcacgg ccctgcaata tggactcagc tctggctctc tgtgtgacct      1544
 Glu 






      <210> 533
      <211> 828
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (1)..(828)

      <400> 533
  atg gcg gac act cat cac gca caa ggg ccc ggt aaa agc gtt ctg ggc      48
  Met Ala Asp Thr His His Ala Gln Gly Pro Gly Lys Ser Val Leu Gly
    1               5                  10                  15

 atc ggg cag cga att gtt tct atc atg gtt gaa atg gta gag aca cgt       96
 Ile Gly Gln Arg Ile Val Ser Ile Met Val Glu Met Val Glu Thr Arg
              20                  25                  30

 ctg cgg ctg gcg gtg gtg gag ctg gaa gag gaa aaa gcg aat ctc ttt      144
 Leu Arg Leu Ala Val Val Glu Leu Glu Glu Glu Lys Ala Asn Leu Phe
          35                  40                  45

 caa ctt tta ctg atg ctg ggc ctg acg atg ctt ttc gct gca ttt ggt      192
 Gln Leu Leu Leu Met Leu Gly Leu Thr Met Leu Phe Ala Ala Phe Gly
      50                  55                  60

 ctt atg agc ctg atg gtg cta att att tgg gcg ggt gac ccg caa tat      240
 Leu Met Ser Leu Met Val Leu Ile Ile Trp Ala Gly Asp Pro Gln Tyr
  65                  70                  75                  80

 cgc ctg aat gcg atg att gcc acc acc gtg gtg ttg ctg cta ctg gca      288
 Arg Leu Asn Ala Met Ile Ala Thr Thr Val Val Leu Leu Leu Leu Ala
                  85                  90                  95

 ctg att ggc gga atc tgg acg cta cgt aaa tcg ggt aag tct acg ctg      336
 Leu Ile Gly Gly Ile Trp Thr Leu Arg Lys Ser Gly Lys Ser Thr Leu
             100                 105                 110

 ctg cgc cat aca cgc cat gag tta gca aac gat cgg cag ctg ctt gag      384
 Leu Arg His Thr Arg His Glu Leu Ala Asn Asp Arg Gln Leu Leu Glu
         115                 120                 125

 gag gag tcc cca gat gtg gtt ggc gag gtg att ctg gtc ggc aat atg      432
 Glu Glu Ser Pro Asp Val Val Gly Glu Val Ile Leu Val Gly Asn Met
     130                 135                 140

 ccc gcc aga gtc att ggt gtg gcg gaa gaa aaa cag tcg atg ttt ggt      480
 Pro Ala Arg Val Ile Gly Val Ala Glu Glu Lys Gln Ser Met Phe Gly
 145                 150                 155                 160

 agc agt aaa gtg ctg cgt gtc tgg cta cct tac agc acg atg tcc ggg      528
 Ser Ser Lys Val Leu Arg Val Trp Leu Pro Tyr Ser Thr Met Ser Gly
                 165                 170                 175

 cga gtt atg ggc cag tcg tgg ctt aac tcc att act gtc agg gtg aaa      576
 Arg Val Met Gly Gln Ser Trp Leu Asn Ser Ile Thr Val Arg Val Lys
             180                 185                 190

 gaa gga ttt gac agc gcc gag gcg gaa cag caa ctc acg cgt tta ctt      624
 Glu Gly Phe Asp Ser Ala Glu Ala Glu Gln Gln Leu Thr Arg Leu Leu
         195                 200                 205

 tca ctg cgc cac gga aag aag gat ttc ttt acc tgg aac atg gac ggc      672
 Ser Leu Arg His Gly Lys Lys Asp Phe Phe Thr Trp Asn Met Asp Gly
     210                 215                 220

 gtc ttg aaa act gtt gaa aag acc aca cgt act tta caa ctg ttt ctg      720
 Val Leu Lys Thr Val Glu Lys Thr Thr Arg Thr Leu Gln Leu Phe Leu
 225                 230                 235                 240

 acg ctt gtg gcg gtg att tcg ctt gtg gtg ggc ggt att ggt gta atg      768
 Thr Leu Val Ala Val Ile Ser Leu Val Val Gly Gly Ile Gly Val Met
                 245                 250                 255

 aat att att ctg gtg tca gtg acc cga ccg acg cgg gaa att ggc att      816
 Asn Ile Ile Leu Val Ser Val Thr Arg Pro Thr Arg Glu Ile Gly Ile
             260                 265                 270

 cgc att gct tga                                                      828
 Arg Ile Ala 
         275





      <210> 534
      <211> 873
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (1)..(873)

      <400> 534
  atg gtg tca gag atg gtg cta cta aag aag tgg ttt tta agc tgt tct      48
  Met Val Ser Glu Met Val Leu Leu Lys Lys Trp Phe Leu Ser Cys Ser
    1               5                  10                  15

 gaa gca gga gat ggg ggt aaa gat tgt tgt ggg cag tgg gaa cag cag       96
 Glu Ala Gly Asp Gly Gly Lys Asp Cys Cys Gly Gln Trp Glu Gln Gln
              20                  25                  30

 gaa aaa gcc ccc gaa gtg gga aca agc ttg gtt tgg gtg gag cat ggt      144
 Glu Lys Ala Pro Glu Val Gly Thr Ser Leu Val Trp Val Glu His Gly
          35                  40                  45

 gag gga cag ctg gag aga gaa gct tct aag ttg gag aag ctg cgg cag      192
 Glu Gly Gln Leu Glu Arg Glu Ala Ser Lys Leu Glu Lys Leu Arg Gln
      50                  55                  60

 atc ctg ttt gga aac aca gtc cat gtc ttt agc tat aac tgg aaa aag      240
 Ile Leu Phe Gly Asn Thr Val His Val Phe Ser Tyr Asn Trp Lys Lys
  65                  70                  75                  80

 gcc tat ttc agg ttc cat gat cct tct tct gaa cta gct ttc act ctg      288
 Ala Tyr Phe Arg Phe His Asp Pro Ser Ser Glu Leu Ala Phe Thr Leu
                  85                  90                  95

 gaa gtg gga aag gga ggg gcc cga agc att cag atg gct gtg caa gga      336
 Glu Val Gly Lys Gly Gly Ala Arg Ser Ile Gln Met Ala Val Gln Gly
             100                 105                 110

 tcc atc atc aaa tac ttg ttg ttt acc agg aaa gga aaa gac tgt aac      384
 Ser Ile Ile Lys Tyr Leu Leu Phe Thr Arg Lys Gly Lys Asp Cys Asn
         115                 120                 125

 ctt ggc aac tta tgt gaa ata agc aag aag gag cag gag caa gcc ttg      432
 Leu Gly Asn Leu Cys Glu Ile Ser Lys Lys Glu Gln Glu Gln Ala Leu
     130                 135                 140

 gcc gcg gcg ctt gct ggc atc ctg tgg gct gca gga gca gct cag aag      480
 Ala Ala Ala Leu Ala Gly Ile Leu Trp Ala Ala Gly Ala Ala Gln Lys
 145                 150                 155                 160

 gcc acc atc tgt ctt gtc act gag gac att tac gtt gcg tcg act ccg      528
 Ala Thr Ile Cys Leu Val Thr Glu Asp Ile Tyr Val Ala Ser Thr Pro
                 165                 170                 175

 gac tac tct gtg gac aat ttc act gag cga gta agt gca gtt ctc cct      576
 Asp Tyr Ser Val Asp Asn Phe Thr Glu Arg Val Ser Ala Val Leu Pro
             180                 185                 190

 gtc ctg gca gat gaa agg cca gtg aag cct gag cat gta ata gac tta      624
 Val Leu Ala Asp Glu Arg Pro Val Lys Pro Glu His Val Ile Asp Leu
         195                 200                 205

 cca tgt gta tgc agg tgg ggc ccc atc cat gct cct gat gtg acc gga      672
 Pro Cys Val Cys Arg Trp Gly Pro Ile His Ala Pro Asp Val Thr Gly
     210                 215                 220

 ggt gcc ttc caa aga ggc agg ctt caa atg gac cta gat gtc acc acc      720
 Gly Ala Phe Gln Arg Gly Arg Leu Gln Met Asp Leu Asp Val Thr Thr
 225                 230                 235                 240

 act cag ctg cta caa cca aat gct gga ggc ttt ctg tgc agg cag aag      768
 Thr Gln Leu Leu Gln Pro Asn Ala Gly Gly Phe Leu Cys Arg Gln Lys
                 245                 250                 255

 ccc ctt gga ctt ctg aca act tgc cgt tct ctg tca ctt ggc tgt gtt      816
 Pro Leu Gly Leu Leu Thr Thr Cys Arg Ser Leu Ser Leu Gly Cys Val
             260                 265                 270

 ccc cta atg ttg ggc cca ggc cct gtg caa ggc tcc cag ctc tgg cag      864
 Pro Leu Met Leu Gly Pro Gly Pro Val Gln Gly Ser Gln Leu Trp Gln
         275                 280                 285

 cag cat tag                                                          873
 Gln His 
     290





      <210> 535
      <211> 3134
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (8)..(2626)

      <400> 535
 ggggaag  atg gcg gca gcc gtt ctg agt ggg ccc tct gcg ggc tcc gcg      49
          Met Ala Ala Ala Val Leu Ser Gly Pro Ser Ala Gly Ser Ala
            1               5                  10

 gct ggg gtt cct ggc ggg acc ggg ggt ctc tcg gca gtg agc tcg ggc       97
 Ala Gly Val Pro Gly Gly Thr Gly Gly Leu Ser Ala Val Ser Ser Gly
  15                  20                  25                  30

 ccg cgg ctc cgc ctg ctg ctg ctg gag agt gtt tct ggt ttg ctg caa      145
 Pro Arg Leu Arg Leu Leu Leu Leu Glu Ser Val Ser Gly Leu Leu Gln
                  35                  40                  45

 cct cga acg ggg tct gcc gtt gct ccg gtg cat ccc cca aac cgc tcg      193
 Pro Arg Thr Gly Ser Ala Val Ala Pro Val His Pro Pro Asn Arg Ser
              50                  55                  60

 gcc cca cat ttg ccc ggg ctc atg tgc cta ttg cgg ctg cat ggg tcg      241
 Ala Pro His Leu Pro Gly Leu Met Cys Leu Leu Arg Leu His Gly Ser
          65                  70                  75

 gtg ggc ggg gcc cag aac ctt tca gct ctt ggg gca ttg gtg agt ctc      289
 Val Gly Gly Ala Gln Asn Leu Ser Ala Leu Gly Ala Leu Val Ser Leu
      80                  85                  90

 agt aat gca cgt ctc agt tcc atc aaa act cgg ttt gag ggc ctg tgt      337
 Ser Asn Ala Arg Leu Ser Ser Ile Lys Thr Arg Phe Glu Gly Leu Cys
  95                 100                 105                 110

 ctg ctg tcc ctg ctg gta ggg gag agc ccc aca gag cta ttc cag cag      385
 Leu Leu Ser Leu Leu Val Gly Glu Ser Pro Thr Glu Leu Phe Gln Gln
                 115                 120                 125

 cac tgt gtg tct tgg ctt cgg agc att cag cag gtg tta cag acc cag      433
 His Cys Val Ser Trp Leu Arg Ser Ile Gln Gln Val Leu Gln Thr Gln
             130                 135                 140

 gac ccg cct gcc aca atg gag ctg gcc gtg gct gtc ctg agg gac ctc      481
 Asp Pro Pro Ala Thr Met Glu Leu Ala Val Ala Val Leu Arg Asp Leu
         145                 150                 155

 ctc cga tat gca gcc cag ctg cct gca ctg ttc cgg gac atc tcc atg      529
 Leu Arg Tyr Ala Ala Gln Leu Pro Ala Leu Phe Arg Asp Ile Ser Met
     160                 165                 170

 aac cac ctc cct ggc ctt ctc acc tcc ctg ctg ggc ctc agg cca gag      577
 Asn His Leu Pro Gly Leu Leu Thr Ser Leu Leu Gly Leu Arg Pro Glu
 175                 180                 185                 190

 tgt gag cag tca gca ttg gaa gga atg aag gct tgt atg acc tat ttc      625
 Cys Glu Gln Ser Ala Leu Glu Gly Met Lys Ala Cys Met Thr Tyr Phe
                 195                 200                 205

 cct cgg gct tgt ggt tct ctc aaa ggc aag ctg gcc tca ttt ttt ctg      673
 Pro Arg Ala Cys Gly Ser Leu Lys Gly Lys Leu Ala Ser Phe Phe Leu
             210                 215                 220

 tct agg gtg gat ccc ttg agc cct cag ctc caa cag ttg gcc tgt gag      721
 Ser Arg Val Asp Pro Leu Ser Pro Gln Leu Gln Gln Leu Ala Cys Glu
         225                 230                 235

 tgt tat tcc cgg ctg ccc tct tta ggg gct ggc ttt tcc caa ggc ctg      769
 Cys Tyr Ser Arg Leu Pro Ser Leu Gly Ala Gly Phe Ser Gln Gly Leu
     240                 245                 250

 aag cac acc gag agc tgg gag cag gag cta cac agt ctg ctg gcc tca      817
 Lys His Thr Glu Ser Trp Glu Gln Glu Leu His Ser Leu Leu Ala Ser
 255                 260                 265                 270

 ctg cac acc ctg ctg ggg gcc ctg tac gag gga gca gag act gct cct      865
 Leu His Thr Leu Leu Gly Ala Leu Tyr Glu Gly Ala Glu Thr Ala Pro
                 275                 280                 285

 gtg cag aat gaa ggc cct ggg gtg gag atg ctg ctg tcc tca gaa gat      913
 Val Gln Asn Glu Gly Pro Gly Val Glu Met Leu Leu Ser Ser Glu Asp
             290                 295                 300

 ggt gat gcc cat gtc ctt ctc cag ctt cgg cag agg ttt tcg gga ctg      961
 Gly Asp Ala His Val Leu Leu Gln Leu Arg Gln Arg Phe Ser Gly Leu
         305                 310                 315

 gcc cgc tgc cta ggg ctc atg ctc agc tct gag ttt gga gct ccc gtg     1009
 Ala Arg Cys Leu Gly Leu Met Leu Ser Ser Glu Phe Gly Ala Pro Val
     320                 325                 330

 tcc gtc cct gtg cag gaa atc ctg gat ttc atc tgc cgg acc ctc agc     1057
 Ser Val Pro Val Gln Glu Ile Leu Asp Phe Ile Cys Arg Thr Leu Ser
 335                 340                 345                 350

 gtc agt agc aag aat att gta agt ggg att tgt cat ctc ttc aga gcc     1105
 Val Ser Ser Lys Asn Ile Val Ser Gly Ile Cys His Leu Phe Arg Ala
                 355                 360                 365

 ctt gct cag gat acc agg caa cca gga aag tac tgg gga cct gag tct     1153
 Leu Ala Gln Asp Thr Arg Gln Pro Gly Lys Tyr Trp Gly Pro Glu Ser
             370                 375                 380

 ccc caa aca gtg tca tcc tgg agt ccg tcc cag aga gct tct act ttt     1201
 Pro Gln Thr Val Ser Ser Trp Ser Pro Ser Gln Arg Ala Ser Thr Phe
         385                 390                 395

 gtc caa ata aca tca ctt cct atg tgt cgt gac aca gga gca cag tgt     1249
 Val Gln Ile Thr Ser Leu Pro Met Cys Arg Asp Thr Gly Ala Gln Cys
     400                 405                 410

 cag agt gta gca aat gct tcc ttg ggg gag ggt gaa ttt ggg gac tca     1297
 Gln Ser Val Ala Asn Ala Ser Leu Gly Glu Gly Glu Phe Gly Asp Ser
 415                 420                 425                 430

 gct gag tca ttg ctg aga ggc cca gcc atc ctt ctt acc ttc cat cca     1345
 Ala Glu Ser Leu Leu Arg Gly Pro Ala Ile Leu Leu Thr Phe His Pro
                 435                 440                 445

 ggg tct att tta gag gat agg ggt ttg att ttg ttg gga gag atg aga     1393
 Gly Ser Ile Leu Glu Asp Arg Gly Leu Ile Leu Leu Gly Glu Met Arg
             450                 455                 460

 tca ggg gtt ggg ttt ctt acc tat gtg tac ata tgt aaa tgg tca ttc     1441
 Ser Gly Val Gly Phe Leu Thr Tyr Val Tyr Ile Cys Lys Trp Ser Phe
         465                 470                 475

 cct gtt tct gtc tct ctc tgg ctc tca ctt tct tcc tcc act ctt tat     1489
 Pro Val Ser Val Ser Leu Trp Leu Ser Leu Ser Ser Ser Thr Leu Tyr
     480                 485                 490

 ctc tgc ccc ttt ttt ctc cag agc ttg cat gga gat ggt ccc tgc ggc     1537
 Leu Cys Pro Phe Phe Leu Gln Ser Leu His Gly Asp Gly Pro Cys Gly
 495                 500                 505                 510

 tgc tgc tgc tgc cct cta tcc acc ttg aag gcc ttg gac ctg ctg tct     1585
 Cys Cys Cys Cys Pro Leu Ser Thr Leu Lys Ala Leu Asp Leu Leu Ser
                 515                 520                 525

 gca ctc atc ctc gcg tgt gga agc cgg ctc ttg cgc ttt ggg atc ctg     1633
 Ala Leu Ile Leu Ala Cys Gly Ser Arg Leu Leu Arg Phe Gly Ile Leu
             530                 535                 540

 atc ggc cgc ctg ctt ccc cag gtc ctc aat tcc tgg agc atc ggt aga     1681
 Ile Gly Arg Leu Leu Pro Gln Val Leu Asn Ser Trp Ser Ile Gly Arg
         545                 550                 555

 gat tcc ctc tct cca ggc cag gag agg cct tac agc acg gtt cgg acc     1729
 Asp Ser Leu Ser Pro Gly Gln Glu Arg Pro Tyr Ser Thr Val Arg Thr
     560                 565                 570

 aag gtg tat gcg ata tta gag ctg tgg gtg cag gtt tgt ggg gcc tcg     1777
 Lys Val Tyr Ala Ile Leu Glu Leu Trp Val Gln Val Cys Gly Ala Ser
 575                 580                 585                 590

 gcg gga atg ctt cag gga gga gcc tct gga gag gcc ctg ctc acc cac     1825
 Ala Gly Met Leu Gln Gly Gly Ala Ser Gly Glu Ala Leu Leu Thr His
                 595                 600                 605

 ctg ctc agc gac atc tcc ccg cca gct gat gcc ctt aag ctg cgt agc     1873
 Leu Leu Ser Asp Ile Ser Pro Pro Ala Asp Ala Leu Lys Leu Arg Ser
             610                 615                 620

 ccg cgg ggg agc cct gat ggg agt ttg cag act ggg aag cct agc gcc     1921
 Pro Arg Gly Ser Pro Asp Gly Ser Leu Gln Thr Gly Lys Pro Ser Ala
         625                 630                 635

 ccc aag aag cta aag ctg gat gtg ggg gaa gct atg gcc ccg cca agc     1969
 Pro Lys Lys Leu Lys Leu Asp Val Gly Glu Ala Met Ala Pro Pro Ser
     640                 645                 650

 cac cgg aaa ggg gat agc aat gcc aac agc gac gtg tgt gcg gct gca     2017
 His Arg Lys Gly Asp Ser Asn Ala Asn Ser Asp Val Cys Ala Ala Ala
 655                 660                 665                 670

 ctc aga ggc ctc agc cgg acc atc ctc atg tgt ggg cct ctc atc aag     2065
 Leu Arg Gly Leu Ser Arg Thr Ile Leu Met Cys Gly Pro Leu Ile Lys
                 675                 680                 685

 gag gag act cac agg aga ctg cat gac ctg gtc ctc ccc ctg gtc atg     2113
 Glu Glu Thr His Arg Arg Leu His Asp Leu Val Leu Pro Leu Val Met
             690                 695                 700

 ggt gta cag cag ggt gag gtc cta ggc agc tcc ccg tac acg agc tcc     2161
 Gly Val Gln Gln Gly Glu Val Leu Gly Ser Ser Pro Tyr Thr Ser Ser
         705                 710                 715

 cgc tgc cgc cgt gaa ctc tac tgc ctg ctg ctg gcg ctg ctg ctg gcc     2209
 Arg Cys Arg Arg Glu Leu Tyr Cys Leu Leu Leu Ala Leu Leu Leu Ala
     720                 725                 730

 ccg tct cct cgc tgc cca cct cct ctt gcc tgt gcc ctg caa gcc ttc     2257
 Pro Ser Pro Arg Cys Pro Pro Pro Leu Ala Cys Ala Leu Gln Ala Phe
 735                 740                 745                 750

 tcc ctc ggc cag cga gaa gat agc ctt gag gtc tcc tct ttc tgc tca     2305
 Ser Leu Gly Gln Arg Glu Asp Ser Leu Glu Val Ser Ser Phe Cys Ser
                 755                 760                 765

 gaa gca ctg gtg acc tgt gct gct ctg acc cac ccc cgg gtt cct ccc     2353
 Glu Ala Leu Val Thr Cys Ala Ala Leu Thr His Pro Arg Val Pro Pro
             770                 775                 780

 ctg cag ccc atg ggc ccc acc tgc ccc aca cct gct cca gtt ccc cct     2401
 Leu Gln Pro Met Gly Pro Thr Cys Pro Thr Pro Ala Pro Val Pro Pro
         785                 790                 795

 cct gag gcc cca tcg ccc ttc agg gcc cca ccg ttc cat cct ccg ggc     2449
 Pro Glu Ala Pro Ser Pro Phe Arg Ala Pro Pro Phe His Pro Pro Gly
     800                 805                 810

 ccc atg ccc tca gtg ggc tcc atg ccc tca gca ggc ccc atg ccc ttc     2497
 Pro Met Pro Ser Val Gly Ser Met Pro Ser Ala Gly Pro Met Pro Phe
 815                 820                 825                 830

 agc agg ccc cat gcc ctc agc agg ccc tgt gcc ctc ggc acg ccc tgg     2545
 Ser Arg Pro His Ala Leu Ser Arg Pro Cys Ala Leu Gly Thr Pro Trp
                 835                 840                 845

 acc tcc cac cac agc caa cca cct agg cct ttc tgt ccc agg cct agt     2593
 Thr Ser His His Ser Gln Pro Pro Arg Pro Phe Cys Pro Arg Pro Ser
             850                 855                 860

 gtc tgt ccc tcc ccg gct tct tcc tgg ccc tga gaaccacc gggcaggctc     2644
 Val Cys Pro Ser Pro Ala Ser Ser Trp Pro 
         865                 870

 aaatgaggac cccatccttg cccctagtgg gactccccca cctactatac ccccagatga   2704

 aacttttggg gggagagtgc ccagaccagc ctttgtccac tatgacaagg aggaggcatc   2764

 tgatgtggag atctccttgg aaagtgactc tgatgacagc gtggtgatcg tgcccgaggg   2824

 gcttcccccc ctgccacccc caccaccctc aggtgccaca ccacccccta tagcccccac   2884

 tgggccacca acagcctccc ctcctgtgcc agcgaaggag gagcctgaag aacttcctgc   2944

 ggccccaggg cctctcccgc cgcccccacc tccgccgccg cctgttcctg gtcctgtgac   3004

 cctccctcca ccccagttgg tccctgaagg gactcctggt gggggaggac ccccagccct   3064

 ggaagaggat ttgacagtta ttaatatcaa cagcagtgat gaagaggagg aggaagaagg   3124

 agaagaggaa                                                          3134




      <210> 536
      <211> 4112
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (842)..(1069)

      <400> 536
 gtcgacccac gcgtccgaga ccagtgtgta gtgcctgtca attccttagg attaatcaaa     60

 tgtaaaatca caagtttgtg tagctgtaac ctttcttaaa tgtacatgat ttatgtacat    120

 gcttttagaa ggtcctacta tatttgtatt ataattagtt taagtaattt ttattacatc    180

 atgtattgct ttattcagtt tgaatacatt tatttattta tttgcagtat caaccagaaa    240

 cactaccaat tgcatcaaat tctcccagtt tttcctggtt gtcaatgcgg ttttcaatgc    300

 acaattaagt catagccatt tggttcgtac caaatgtgtc agaatctaac agcatccgat    360

 aggctgtaag ttggggagtt gctaagaaaa tgcaacgtgg tacaggctgt ccgcctcagc    420

 cctggaaatc tcccagacct cccccagctt catcctgtgt agcacgactc aacgtgcacc    480

 ctgaatcttc tcaggtcttc caggtcatgc tgtagctgtc actgccatgc agcccttttt    540

 tttactccgg acagctcatg tactgaagcg tcatgaaaga aaggctgtgg tctgagccct    600

 tctctcccat ctcctgtctt tgtcctgtca agtgctggag ccagagctcc tacagctgcc    660

 cttggtggtt tctcctgttc agcgatggtg ggcacaggtt ctgctattcc agggctccag    720

 cttcctccca ggtctaccca gagctccaga tgggggtctg aattaacctc tcttggtggc    780

 ctggagattt ttagtcattg acaagaatac cttgtaacca gggaacccca aggcccagta    840

 a    atg att ctg tat acc att ttc ttg aag gta caa gaa gat tct gcc     886
      Met Ile Leu Tyr Thr Ile Phe Leu Lys Val Gln Glu Asp Ser Ala
        1               5                  10                  15

 gac tat ggg gat ctt tgg gcc agt ttg agg att gct ttc cct ctg agg      934
 Asp Tyr Gly Asp Leu Trp Ala Ser Leu Arg Ile Ala Phe Pro Leu Arg
                  20                  25                  30

 ttc ttt ctc tct gtc agc cac act ttc tca ccc aac ttc aga cac acc      982
 Phe Phe Leu Ser Val Ser His Thr Phe Ser Pro Asn Phe Arg His Thr
              35                  40                  45

 ctg cca gcc ttt ccc cta ctc att cac tct tcc cct tcc ctc aac tta     1030
 Leu Pro Ala Phe Pro Leu Leu Ile His Ser Ser Pro Ser Leu Asn Leu
          50                  55                  60

 atc gtc tat ccc gtt gcc tgc tgt ttg act gtg cac tga aggcaggtgg      1079
 Ile Val Tyr Pro Val Ala Cys Cys Leu Thr Val His 
      65                  70                  75

 atggagtcag tcctcagttg cccctgctgg ccttcctggt gcttaccatc agcccaatct   1139

 ttgcacagtc cttgttgttc ttacttctct gcatgcattc cttcagaaga tcagtcatca   1199

 actttttctt aattcctctg tgacacacaa tgggaattca aaggaagaga tcttaaaagt   1259

 cacaacagtt ctttatctta ataatcccct ccccattcac cttactacat gcagactcac   1319

 ctcacaccct tacaacttga agctgaaaat ttaaaagtaa tttccctttt tgcagctttt   1379

 cctcaggtta aggctttgat ctgcctgaga gtaactctaa aaggagggaa gataaatatg   1439

 ggataaaatc cacaaagtgt agcttctaat tcctttggaa gtttaaaaaa tttccacata   1499

 tctgatgctt cttttgtcag gtgcagaagc acaaaaacat attccgaagc caactgatag   1559

 ggaatttggg gattattgtc agtttggaga atttgctgtg ttatttcttc atttccatgg   1619

 atagctcata gttggctctt tctgggtgag taattatgtg taatatagat caaatctttt   1679

 actaaggtta cagctacatg ttaggggagg ctatgaaaat actatattat tataatttcc   1739

 agtgcagtga ttgttgtgag aaataacttt catggtaacc ctaggaaaat gggcacctgc   1799

 caccatcctg agaagtcctc acacaatgcc ctttctctct tacacacaca cacaacacaa   1859

 catacacaca cacacacccc cgtcactaat tcatagagtt ccttagcagg catagtcaag   1919

 gatcctctgg gtaatgtcag ctgcttagtg ataaaacaga gccaaaacta gtgcatcctg   1979

 ttgaaagtaa tgcagaaaca gtacctgggt ccagatatgc tttcctgcgg cgctttcctc   2039

 tgttacctcg tttcatcctc acagcagcat ggacggtagg tggggtcgct tctacaatca   2099

 tttctgatga tagcttggga atagagatag gggcagtgac ttgcctgatg tcgcacagcc   2159

 ctccggctgt cctgctttcc catatggagc agtggtggtg tgggcacctg tgatgcagga   2219

 gactttaaaa atgtcgtgag gtcacgtgct gcccctcctg gtacgtgtgg aatgcccctg   2279

 gccagcaagg ggtgcttttt tatcagagtt ggcagctggc atgtgggaac cgagcaagtg   2339

 ctgcgtacca agttacttgt tttaaggaga ccaagtgctc agcgccaggt ggttttcttt   2399

 tttgtcatag ttacttgcta taactcagct tgacttctgt catgaatcag tgctctctgg   2459

 gaggatgcaa tactctgttt gggcattaat tggtagcagg ttgtctcaac caaaaagaca   2519

 ggaaacagca aaagcctctc tgaaattaag aggaaagtta ctctccccac acccatcaga   2579

 gtctttattg gagccaccag gtgagctgtg cagcctggac aggcctgcag ctataggcca   2639

 ccttcccagt ttaggtcctc agcacagggg agcccaagtc actgggtgcc ttccgagggc   2699

 tgtcactggg caggccatat acaagtcagt gtgtgcgtgg gcactgcagt gtgtgcatgc   2759

 cgtaggtgtt gatgggtgct aggaggggtg tcgtgtgcat gcgcgttgaa gaggatctgt   2819

 attgccgtga cctctgttca tggatgagtg cattgtaatt tgttctcagg ctgtgctgtg   2879

 agggccgcct taacccttgc tcccttccct tctagagctg ccttaagttc tccagaactt   2939

 ttcttctgta aaggatatct tgcctggaag ggatatcttg ccctgtttct caaggttttg   2999

 tgagagtttt gactggatgt ggccctgcat gaccctcctt ctcctgtact tcctctttcc   3059

 tttccaaatg ggaattagaa ctgtggggca gcaacagtct cagagccagt gagaggccag   3119

 cttagagaat gcttctgagt tagtgggact ctgtgtcaca agtaagcaaa tgaatatatg   3179

 aaagaaatta tggagataag ttagattctt ggtaatactt aaatgtcttg ctttctacta   3239

 accttttgtt actaaaggta aagggtataa ctcaaacttt ttgtggacat tcttttcaaa   3299

 attttttaag aaccctgtac tataaaaggt tgagtaaaaa caggaaagcg tgctataagt   3359

 tcaaatctgt tgtattaccc taaattagat aaaccaacct gaattatagt agatttctca   3419

 atagatgagg aactgaaaaa tactatgtaa aatatcttcc aaaatgcttt ttatactttt   3479

 tttatttgta atttggtcta tctaaaatgt tcgttagctt aacttaatgg gcgttattgg   3539

 attcatatga ctaacgtttc ctcagtattg taatgcttga aatatttgaa agaaaaaatg   3599

 ttgtttttta gttgaaactg gtatatataa ttcagtgctt ggcaggttag tatattttta   3659

 tgcatttttc agagtcagca gtttcaaatc ttattgttat catgttataa aattttagcc   3719

 cacatttcag gctccgtaaa tcatttgagc cattattttt tcccaacaaa tggtgaattt   3779

 tttctttaaa tgtggatata tatgttgtaa tttatgattc ctggttatgt atttttgtgg   3839

 gatcctgcag gtaaaattga cttttttgtg tcttttggga gaattcaatt gcgctaacag   3899

 tgttgcgcaa aaatgagtcc atgccattta catatggttt tcatttaccg ttaatttcct   3959

 atgaatggac ttctttacta aacgggatga acttgcggtt caaattttcc ttgggtcgga   4019

 aagactcctg gtcgtagaat gggcattgaa agtttggaaa tccctaaggg acaatggacg   4079

 ggttctgtac acccttctgg taaattccct aag                                4112




      <210> 537
      <211> 7272
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (1582)..(5208)

      <400> 537
 gtcctggacc aagacacaga cgccattgca gtccatgtag tcagagtgct gacctgcatc     60

 atgagtgact ccccctcggc caaggaggtg tttaaggagc gcatcggcta ccctcacctg    120

 caggaggttc tgcagagcca tggtcccccc acccatcggc tgttgcaaga gctgctcaac    180

 atggctgtgg agggtgacca cagcatgtgc ccacctccac caatccgcaa cgagcagccg    240

 gtactggtgc tggcgcagtg gctgccgtca ttgcccaccg ctgagctgcg gctcttccta    300

 gcgcaacgcc tcaggtggct ctgtgacagc tgccctgcca gccgtgccac ctgtgtgcag    360

 gcaggcctgg tgggctgcct gttggagaca ctcagcacag ggctagccct ggaggcccgc    420

 tgccaagagc agctgctggc actgctacaa gcactgggcc gtgtatcaat aaggcccatg    480

 gagctgcgtc acctgctgcg cccccggcca ggattggact cggaaccagg cggagctgag    540

 gctggaaagg cccgacacgc aggtgctgtc atccgcacat tatcaggcat ggccaggcac    600

 cagggtcctg cacgtgctct gcgctacttt gacctcacgc ccagcatggc gggcatcatg    660

 gtaccccctg tacagcgatg gccagggcct ggcttcacct ttcatgcctg gctctgtctg    720

 caccctatgg atacagcacc tacccctgcc cccacccgac cactccagcg aaagcagctg    780

 tacagcttct ttaccagcag cggctcaggg tttgaggcct tcttcacggc ggccgggacc    840

 ctggtggtgg ctgtgtgcac acggaaggag tatttgacca tgagtttgcc cgaagtgtcc    900

 tttgccgact ctgcctggca ctgcgtggct atcgtccatg tgcctgggcg ccggcccttc    960

 agccagaacc tggtccatgt ctacaaagac ggccatctgg tcaagacagc accccttcgc   1020

 tgcccctccc tcagtgagcc tttctcctcc tgctgtatcg gctccgctgg ataccgcaca   1080

 acgaccacca ccacagggct gcccacacca ccagtccccg ccaccctggc ctacactcac   1140

 cccgccctca cccgctccca gtcagtccca gcctccacag ggcttggctg ggggtccggg   1200

 ctggtggccc ccctgcagga gggcagcatc gactctaccc tcgcaggcac ccaggacact   1260

 cggtggggca gccccacatc cctggagggt gagctggggg ctgtggccat ctttcacgaa   1320

 gccctgcagg cgacggctct gaggaccctg tgcaccctgg ggcccaatga gacggcaccc   1380

 ttcaagcctg agggggagct gcatgagctc agcaccaggc tgctcctcca ttactcacct   1440

 catgcttgta agaacaacat ctgcctggac ctgtccccca gtcatgggct tgatgggcgc   1500

 ctgacgggcc acagagtgga gacctgggat gtgaaggtct gtgagcacgt gtgggtggat   1560

 gtggtgaact gcgttggggg t  atg ggt gcc ctg ctg ccc ctg ctg gag cga    1611
                          Met Gly Ala Leu Leu Pro Leu Leu Glu Arg
                            1               5                  10

 gta gct gca cag ccc aaa gag gct gaa gca ggt cca gct gaa acg cat     1659
 Val Ala Ala Gln Pro Lys Glu Ala Glu Ala Gly Pro Ala Glu Thr His
                  15                  20                  25

 gac ctc gtg ggt cct gaa ctg acc tct ggt cac aac acc cag ggc ctg     1707
 Asp Leu Val Gly Pro Glu Leu Thr Ser Gly His Asn Thr Gln Gly Leu
              30                  35                  40

 gtt ctc cca ttg ggt aaa tct tca gag gaa cgg atg gag agg aac gca     1755
 Val Leu Pro Leu Gly Lys Ser Ser Glu Glu Arg Met Glu Arg Asn Ala
          45                  50                  55

 gtg gct gct ttt ctg ctg atg ctg cgg aac ttc ctt cag ggt cac atg     1803
 Val Ala Ala Phe Leu Leu Met Leu Arg Asn Phe Leu Gln Gly His Met
      60                  65                  70

 gtg aac caa gag agc ctg gtg cag tgc cag ggg cct gcc atc atc ggg     1851
 Val Asn Gln Glu Ser Leu Val Gln Cys Gln Gly Pro Ala Ile Ile Gly
  75                  80                  85                  90

 gcc ctc ctg cga aag gtc cca agc tgg gcc atg gac atg aac gtg ctc     1899
 Ala Leu Leu Arg Lys Val Pro Ser Trp Ala Met Asp Met Asn Val Leu
                  95                 100                 105

 atg tcc gcc cag ctg ctg atg gag cag gtg gca gct gag ggc agc ggg     1947
 Met Ser Ala Gln Leu Leu Met Glu Gln Val Ala Ala Glu Gly Ser Gly
             110                 115                 120

 ccc ctc ctg tac cta ctc tac cag cat ttg ctc ttc aac ttt cac ctc     1995
 Pro Leu Leu Tyr Leu Leu Tyr Gln His Leu Leu Phe Asn Phe His Leu
         125                 130                 135

 tgg acc ctc agt gac ttc gcc gtg cgc ctc ggt cac atc cag tac atg     2043
 Trp Thr Leu Ser Asp Phe Ala Val Arg Leu Gly His Ile Gln Tyr Met
     140                 145                 150

 tcc agc ata gtt cgg gag cac aga cag aag ctg cgg aag aag tac ggc     2091
 Ser Ser Ile Val Arg Glu His Arg Gln Lys Leu Arg Lys Lys Tyr Gly
 155                 160                 165                 170

 gtc cag ttt atc ttg gat gct ctg cgc acc cac tac agc ccg cag cgg     2139
 Val Gln Phe Ile Leu Asp Ala Leu Arg Thr His Tyr Ser Pro Gln Arg
                 175                 180                 185

 gag cgc ccc ctg gct gct gac gac cta cgc acc gtg cag acc tcc ctc     2187
 Glu Arg Pro Leu Ala Ala Asp Asp Leu Arg Thr Val Gln Thr Ser Leu
             190                 195                 200

 ctg ggc ctg gcg agg gag ttc ctg gtg cgg agt ctc tca gca gat gac     2235
 Leu Gly Leu Ala Arg Glu Phe Leu Val Arg Ser Leu Ser Ala Asp Asp
         205                 210                 215

 gtg cag gtc acg cag acc atg ctg agc ttt ttg gcg gcc aca ggc gat     2283
 Val Gln Val Thr Gln Thr Met Leu Ser Phe Leu Ala Ala Thr Gly Asp
     220                 225                 230

 gac ggt cag gcg gtg ggt gcg ctg gac ctg ctg ctg gcc ctg ctg cac     2331
 Asp Gly Gln Ala Val Gly Ala Leu Asp Leu Leu Leu Ala Leu Leu His
 235                 240                 245                 250

 ggt tcc ctg gtg cag gag tcc ttg gct gtc ttt ctg ttg gag cca ggg     2379
 Gly Ser Leu Val Gln Glu Ser Leu Ala Val Phe Leu Leu Glu Pro Gly
                 255                 260                 265

 aac ctc gaa gtg cta ctg gcc ctg cta gtg cgg cca ggg tca ctg ccc     2427
 Asn Leu Glu Val Leu Leu Ala Leu Leu Val Arg Pro Gly Ser Leu Pro
             270                 275                 280

 ctg ctg ccc gat cga gtc tgc aag atc ctg cgc aga ctg cag cag aat     2475
 Leu Leu Pro Asp Arg Val Cys Lys Ile Leu Arg Arg Leu Gln Gln Asn
         285                 290                 295

 gag cgg cta cct gag cgg agc cgc cag cgc ctc cgg ctg cgg gag tgt     2523
 Glu Arg Leu Pro Glu Arg Ser Arg Gln Arg Leu Arg Leu Arg Glu Cys
     300                 305                 310

 ggt ctc cag ggt ctg gtt gcc tgc ttg cct gag ggg act gtt tcc ccc     2571
 Gly Leu Gln Gly Leu Val Ala Cys Leu Pro Glu Gly Thr Val Ser Pro
 315                 320                 325                 330

 cag ctc tgc cag ggc ctc tac aag ctg ttc ctg ggg gca gat tgc ctg     2619
 Gln Leu Cys Gln Gly Leu Tyr Lys Leu Phe Leu Gly Ala Asp Cys Leu
                 335                 340                 345

 aac ctc tca gat ctg ctg gct gtg gta cag ctg tcc ctc cag gct gac     2667
 Asn Leu Ser Asp Leu Leu Ala Val Val Gln Leu Ser Leu Gln Ala Asp
             350                 355                 360

 ctc agc gtt cgc cta gac atc tgt cgc cag ctt ttc cac ctc atc tac     2715
 Leu Ser Val Arg Leu Asp Ile Cys Arg Gln Leu Phe His Leu Ile Tyr
         365                 370                 375

 gga cag cca gat gta gtg cgg ctt ctg gcc cga cag gct ggc tgg caa     2763
 Gly Gln Pro Asp Val Val Arg Leu Leu Ala Arg Gln Ala Gly Trp Gln
     380                 385                 390

 gat gtg ctg acc cgg cta tat gtc ctg gag gct gcc aca gcc ggc agc     2811
 Asp Val Leu Thr Arg Leu Tyr Val Leu Glu Ala Ala Thr Ala Gly Ser
 395                 400                 405                 410

 ccc cct ccg tct tcc cca gag tca cct acc tcc ccc aag cca gcc cca     2859
 Pro Pro Pro Ser Ser Pro Glu Ser Pro Thr Ser Pro Lys Pro Ala Pro
                 415                 420                 425

 ccc aag cca ccc act gag tca cct gct gag cct tca gat gtc ttc ctg     2907
 Pro Lys Pro Pro Thr Glu Ser Pro Ala Glu Pro Ser Asp Val Phe Leu
             430                 435                 440

 ccc tca gag gcc ccc tgc cct gac cct gat ggc ttt tac cat gct ctc     2955
 Pro Ser Glu Ala Pro Cys Pro Asp Pro Asp Gly Phe Tyr His Ala Leu
         445                 450                 455

 tcc cca ttc tgc acg ccc ttt gac ctg ggc ctg gaa cgg tct agt gta     3003
 Ser Pro Phe Cys Thr Pro Phe Asp Leu Gly Leu Glu Arg Ser Ser Val
     460                 465                 470

 gga tca ggc aac act gct ggt ggt ggc ggc agc agt ggg act ctt act     3051
 Gly Ser Gly Asn Thr Ala Gly Gly Gly Gly Ser Ser Gly Thr Leu Thr
 475                 480                 485                 490

 cca gcc agc cag ccc ggc act cct tcg cca ctg gat ggg ccg cgg ccc     3099
 Pro Ala Ser Gln Pro Gly Thr Pro Ser Pro Leu Asp Gly Pro Arg Pro
                 495                 500                 505

 ttt cct gct gct cct ggc cgc cac agc tcc agt ctc tcc aat gtg ctg     3147
 Phe Pro Ala Ala Pro Gly Arg His Ser Ser Ser Leu Ser Asn Val Leu
             510                 515                 520

 gag gac ggc agc ctc ccg gag ccc acc att agc ggg gat gat acc tcg     3195
 Glu Asp Gly Ser Leu Pro Glu Pro Thr Ile Ser Gly Asp Asp Thr Ser
         525                 530                 535

 aac acc agc aac cca cag caa acc tct gag gaa gag ttg tgc aat ctg     3243
 Asn Thr Ser Asn Pro Gln Gln Thr Ser Glu Glu Glu Leu Cys Asn Leu
     540                 545                 550

 ctc acc aac gtg ctg ttc tcg gtg acg tgg cgt ggc gtg gaa ggc agc     3291
 Leu Thr Asn Val Leu Phe Ser Val Thr Trp Arg Gly Val Glu Gly Ser
 555                 560                 565                 570

 gat gag gct gcc tgg cgg gag cgt ggc cag gtt ttc tca gtg ctc acc     3339
 Asp Glu Ala Ala Trp Arg Glu Arg Gly Gln Val Phe Ser Val Leu Thr
                 575                 580                 585

 cag ctg ggg gcc tca gcc aca ctt gtg cgc cca cca gac tgc atc aag     3387
 Gln Leu Gly Ala Ser Ala Thr Leu Val Arg Pro Pro Asp Cys Ile Lys
             590                 595                 600

 cgc agc ctc ctg gag atg atg ctg gag tca gcc ctg acc gac atc aaa     3435
 Arg Ser Leu Leu Glu Met Met Leu Glu Ser Ala Leu Thr Asp Ile Lys
         605                 610                 615

 gag gcc ccc gtg ggg gtc ctg gcc agc ctc acc cag caa gcg ctt tgg     3483
 Glu Ala Pro Val Gly Val Leu Ala Ser Leu Thr Gln Gln Ala Leu Trp
     620                 625                 630

 ctg ctg cgt ctg ctg cag gac ttc ctg tgt gct gaa ggc cat ggt aac     3531
 Leu Leu Arg Leu Leu Gln Asp Phe Leu Cys Ala Glu Gly His Gly Asn
 635                 640                 645                 650

 cag gaa ctg tgg agt gag aag ctc ttt gaa ggt gta tgc agc cta ctt     3579
 Gln Glu Leu Trp Ser Glu Lys Leu Phe Glu Gly Val Cys Ser Leu Leu
                 655                 660                 665

 gat cgc ctg gga gcc tgg ccc cac ctg gcc aac ggc aca gct gat ctc     3627
 Asp Arg Leu Gly Ala Trp Pro His Leu Ala Asn Gly Thr Ala Asp Leu
             670                 675                 680

 cgt gag atg gcg cag att ggc cta cgg ctt gta ctt ggc tac atc ctg     3675
 Arg Glu Met Ala Gln Ile Gly Leu Arg Leu Val Leu Gly Tyr Ile Leu
         685                 690                 695

 ctg gaa gac cca cag ctg cat gcc cag gcc tac gtg aga ttg cac atg     3723
 Leu Glu Asp Pro Gln Leu His Ala Gln Ala Tyr Val Arg Leu His Met
     700                 705                 710

 ctg cta cag act gca gtg cca gcc cgc cgc gag gag gcc tgc tat gtg     3771
 Leu Leu Gln Thr Ala Val Pro Ala Arg Arg Glu Glu Ala Cys Tyr Val
 715                 720                 725                 730

 ctc tcc aag ctg gag gct gca ctg ggg cgg gtg ctg aac acc tct tcc     3819
 Leu Ser Lys Leu Glu Ala Ala Leu Gly Arg Val Leu Asn Thr Ser Ser
                 735                 740                 745

 ttg gag tca gcc act gat gag gca ggg tcc cca ctt gca gct gca gca     3867
 Leu Glu Ser Ala Thr Asp Glu Ala Gly Ser Pro Leu Ala Ala Ala Ala
             750                 755                 760

 gct gca gca gct gca gag cgc tgc tcc tgg ctg gta cca ctg gtg cgc     3915
 Ala Ala Ala Ala Ala Glu Arg Cys Ser Trp Leu Val Pro Leu Val Arg
         765                 770                 775

 acg ctg cta gac cgt gcc tat gag ccg ctg ggg ctg cag tgg gga ctg     3963
 Thr Leu Leu Asp Arg Ala Tyr Glu Pro Leu Gly Leu Gln Trp Gly Leu
     780                 785                 790

 ccc tcc ctg cca ccc acc aat ggc agc ccc acc ttc ttt gaa gac ttc     4011
 Pro Ser Leu Pro Pro Thr Asn Gly Ser Pro Thr Phe Phe Glu Asp Phe
 795                 800                 805                 810

 cag gct ttt tgt gcc aca ccc gaa tgg cgc cac ttc atc gac aaa cag     4059
 Gln Ala Phe Cys Ala Thr Pro Glu Trp Arg His Phe Ile Asp Lys Gln
                 815                 820                 825

 gta cag cca acc atg tcc cag ttc gaa atg gac acg tat gct aag agc     4107
 Val Gln Pro Thr Met Ser Gln Phe Glu Met Asp Thr Tyr Ala Lys Ser
             830                 835                 840

 cac gac ctt atg tca ggt ttc tgg aat gcc tgc tat gac atg ctt atg     4155
 His Asp Leu Met Ser Gly Phe Trp Asn Ala Cys Tyr Asp Met Leu Met
         845                 850                 855

 agc agt ggg cag cgg cgc cag tgg gag cgc gcc cag agt cgt cgg gcc     4203
 Ser Ser Gly Gln Arg Arg Gln Trp Glu Arg Ala Gln Ser Arg Arg Ala
     860                 865                 870

 ttc cag gag ctg gtg ctg gaa cct gcg cag agg cgg gcg cgc ctg gag     4251
 Phe Gln Glu Leu Val Leu Glu Pro Ala Gln Arg Arg Ala Arg Leu Glu
 875                 880                 885                 890

 ggg cta cgc tac acg gca gtg ctg aag cag cag gca acg cag cac tcc     4299
 Gly Leu Arg Tyr Thr Ala Val Leu Lys Gln Gln Ala Thr Gln His Ser
                 895                 900                 905

 atg gcc ctg ctg cac tgg ggg gcg ctg tgg cgc cag ctc gcc agc cca     4347
 Met Ala Leu Leu His Trp Gly Ala Leu Trp Arg Gln Leu Ala Ser Pro
             910                 915                 920

 tgt ggg gcc tgg gcg ctg agg gac act ccc atc ccc cgc tgg aaa ctg     4395
 Cys Gly Ala Trp Ala Leu Arg Asp Thr Pro Ile Pro Arg Trp Lys Leu
         925                 930                 935

 tcc agc gcc gag aca tat tca cgc atg cgt ctg aag ctg gtg ccc aac     4443
 Ser Ser Ala Glu Thr Tyr Ser Arg Met Arg Leu Lys Leu Val Pro Asn
     940                 945                 950

 cat cac ttc gac cct cac ctg gaa gcc agc gct ctc cga gac aat ctg     4491
 His His Phe Asp Pro His Leu Glu Ala Ser Ala Leu Arg Asp Asn Leu
 955                 960                 965                 970

 ggt gag gtt ccc ctg aca ccc acc gag gag gcc tca ctg cct ctg gca     4539
 Gly Glu Val Pro Leu Thr Pro Thr Glu Glu Ala Ser Leu Pro Leu Ala
                 975                 980                 985

 gtg acc aaa gag gcc aaa gtg agc acc cca ccc gag ttg ctg cag gag     4587
 Val Thr Lys Glu Ala Lys Val Ser Thr Pro Pro Glu Leu Leu Gln Glu
             990                 995                1000

 gac cag ctc ggc gag gac gag ctg gct gag ctg gag acc ccg atg gag     4635
 Asp Gln Leu Gly Glu Asp Glu Leu Ala Glu Leu Glu Thr Pro Met Glu
        1005                1010                1015

 gca gca gaa ctg gat gag cag cgt gag aag ctg gtg ctg tcg gcc gag     4683
 Ala Ala Glu Leu Asp Glu Gln Arg Glu Lys Leu Val Leu Ser Ala Glu
    1020                1025                1030

 tgc cag ctg gtg acg gta gtg gcc gtg gtc cca ggg ctg ctg gag gtc     4731
 Cys Gln Leu Val Thr Val Val Ala Val Val Pro Gly Leu Leu Glu Val
1035                1040                1045                1050

 acc aca cag aat gta tac ttc tac gat ggc agc act gag cgc gtg gaa     4779
 Thr Thr Gln Asn Val Tyr Phe Tyr Asp Gly Ser Thr Glu Arg Val Glu
                1055                1060                1065

 acc gag gag ggc atc ggc tat gat ttc cgg cgc cca ctg gcc cag ctg     4827
 Thr Glu Glu Gly Ile Gly Tyr Asp Phe Arg Arg Pro Leu Ala Gln Leu
            1070                1075                1080

 cgt gag gtc cac ctg cgg cgt ttc aac ctg cgc cgt tca gca ctt gag     4875
 Arg Glu Val His Leu Arg Arg Phe Asn Leu Arg Arg Ser Ala Leu Glu
        1085                1090                1095

 ctc ttc ttt atc gat cag gcc aac tac ttc ctc aac ttc cca tgc aag     4923
 Leu Phe Phe Ile Asp Gln Ala Asn Tyr Phe Leu Asn Phe Pro Cys Lys
    1100                1105                1110

 gtg ggc acg acc cca gtc tca tct cct agc cag act ccg aga ccc cag     4971
 Val Gly Thr Thr Pro Val Ser Ser Pro Ser Gln Thr Pro Arg Pro Gln
1115                1120                1125                1130

 cct ggc ccc atc cca ccc cat acc cag gta cgg aac cag gtg tac tcg     5019
 Pro Gly Pro Ile Pro Pro His Thr Gln Val Arg Asn Gln Val Tyr Ser
                1135                1140                1145

 tgg ctc ctg cgc cta cgg ccc ccc tct caa ggc tac cta agc agc cgc     5067
 Trp Leu Leu Arg Leu Arg Pro Pro Ser Gln Gly Tyr Leu Ser Ser Arg
            1150                1155                1160

 tcc ccc cag gag atg ctg cgt gcc tca ggc ctt acc cag aaa tgg gta     5115
 Ser Pro Gln Glu Met Leu Arg Ala Ser Gly Leu Thr Gln Lys Trp Val
        1165                1170                1175

 cag cgt gag ata tcc aac ttc gag tac ttg atg caa ctc aac acc att     5163
 Gln Arg Glu Ile Ser Asn Phe Glu Tyr Leu Met Gln Leu Asn Thr Ile
    1180                1185                1190

 gcg ggg cgg acc tac aat gac ctg tct cag tac cct gtg gta tga aag     5211
 Ala Gly Arg Thr Tyr Asn Asp Leu Ser Gln Tyr Pro Val Val 
1195                1200                1205

 ctttgaggac ccagcaggga ccattgacaa gttccactat ggcacccact actccaatgc   5271

 agcaggtgtg atgcactacc tcatccgcgt ggagcccttc acctccctgc acgtccagct   5331

 gcaaagtggc cgctttgact gctccgaccg gcagttccac tcggtggcgg cagcctggca   5391

 ggcacgcctg gagagccctg ccgatgtgaa ggagctcatc ccggaattct tctactttcc   5451

 tgacttcctg gagaaccaga acggttttga cctgggctgt ctccagctga ccaacgagaa   5511

 ggtaggcgat gtggtgctac ccccgtgggc cagctctcct gaggacttca tccagcagca   5571

 ccgccaggct ctggagtcgg agtatgtgtc tgcacaccta cacgagtgga tcgacctcat   5631

 ctttggctac aagcagcggg ggccagccgc cgaggaggcc ctcaatgtct tctattactg   5691

 cacctatgag ggggctgtag acctggacca tgtgacagat gagcgggaac ggaaggctct   5751

 ggagggcatt atcagcaact ttgggcagac tccctgtcag ctgctgaagg agccacatcc   5811

 aactcggctc tcagctgagg aagcagccca tcgccttgca cgcctggaca ctaactcacc   5871

 tagcatcttc cagcacctgg acgaactcaa ggcattcttc gcagaggttg tcagtgatgg   5931

 tgtacccctg gtgctagccc tggtccccca ccggcagccc cactccttca tcacccaggg   5991

 ttccccagac ctgttggtga ctgtgagtgc cagtgggctg ctgggcaccc acagctggtt   6051

 gccctatgac cgcaacataa gcaactactt cagcttcagc aaagacccca ccatgggcag   6111

 ccacaagacg cagcgactgc tgagtggccc gtgggtgcca ggcagtggtg tgagtggaca   6171

 agcactggca gtggccccgg atggaaagct gctattcagc ggtggccact gggatggcag   6231

 cctgcgggtg actgcactac cccgtggcaa gctgttgagc cagctcagct gccaccttga   6291

 tgtagtaacc tgccttgcac tggacacctg tggcatctac ctcatctcag gctcccggga   6351

 caccacgtgc atggtgtggc ggctcctgca tcagggtggt ctgtcagtag gcctggcacc   6411

 aaagcctgtg caggtcctgt atgggcatgg ggctgcagtg agctgtgtgg ccatcagcac   6471

 tgaacttgac atggctgtgt ctggatctga ggatggaact gtgatcatac acactgtacg   6531

 ccgcggacag tttgtagcgg cactacggcc tctgggtgcc acattccctg gacctatttt   6591

 ccacctggca ttggggtccg aaggccagat tgtggtacag agctcagcgt gggaacgtcc   6651

 tggggcccag gtcacctact ccttgcacct gtattcagtc aatgggaagt tgcgggcttc   6711

 actgcccctg gcagagcagc ctacagccct gacggtgaca gaggactttg tgttgctggg   6771

 caccgcccag tgcgccctgc acatcctcca actaaacaca ctgctcccgg ccgcgcctcc   6831

 cttgcccatg aaggtggcca tccgcagcgt ggccgtgacc aaggagcgca gccacgtgct   6891

 ggtgggcctg gaggatggca agctcatcgt ggtggtcgcg gggcagccct ctgaggtgcg   6951

 cagcagccag ttcgcgcgga agctgtggcg gtcctcgcgg cgcatctccc aggtgtcctc   7011

 gggagagacg gaatacaacc ctactgaggc gcgctgaacc tggccagtcc ggctgctcgg   7071

 gccccgcccc cggcaggcct ggcccgggag gccccgccca gaagtcggcg ggaacacccc   7131

 ggggtgggca gcccaggggg gtgagcgggg cccaccctgc ccagctcagg gattggcggg   7191

 cgatgttacc ccctcaggga ttggcgggcg gaagtcccgc ccctcgccgg ctgaggggcc   7251

 gccctgaggg ccagcactgg c                                             7272




      <210> 538
      <211> 1161
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (1)..(1161)

      <400> 538
  atg gct gcc ctg tac ctg ctt atg gaa agc tgg atc tcc aga ggg gca      48
  Met Ala Ala Leu Tyr Leu Leu Met Glu Ser Trp Ile Ser Arg Gly Ala
    1               5                  10                  15

 cag gcc atg gtg ttc aag ccc gac cac agc cct gct gcc tgg gca tca       96
 Gln Ala Met Val Phe Lys Pro Asp His Ser Pro Ala Ala Trp Ala Ser
              20                  25                  30

 gca cca caa gtg ggt caa ctg gac agt cgg tgc cta ccc agt gga atc      144
 Ala Pro Gln Val Gly Gln Leu Asp Ser Arg Cys Leu Pro Ser Gly Ile
          35                  40                  45

 ctg cat cct ctc tct cca cac aag atc tgg ctc tat ggc gga ctt tgg      192
 Leu His Pro Leu Ser Pro His Lys Ile Trp Leu Tyr Gly Gly Leu Trp
      50                  55                  60

 ttt ctg cac ctg cac atg aaa gag agg gag gct gat ggg ccc cct agc      240
 Phe Leu His Leu His Met Lys Glu Arg Glu Ala Asp Gly Pro Pro Ser
  65                  70                  75                  80

 tca tat act cgg gga tct gag gat gga gac ccc tca aat atc cag aaa      288
 Ser Tyr Thr Arg Gly Ser Glu Asp Gly Asp Pro Ser Asn Ile Gln Lys
                  85                  90                  95

 agg agc tgg gaa atc agt act gcc ccc ggg tgg gag cca ccg gat gat      336
 Arg Ser Trp Glu Ile Ser Thr Ala Pro Gly Trp Glu Pro Pro Asp Asp
             100                 105                 110

 cca gac acg ggc tct gag tgt tca cat cca gag gtc tcc cca tct cca      384
 Pro Asp Thr Gly Ser Glu Cys Ser His Pro Glu Val Ser Pro Ser Pro
         115                 120                 125

 cgc ttc gtg gca gcg aag acc cag acg aac cag tcg ggg aaa aaa gct      432
 Arg Phe Val Ala Ala Lys Thr Gln Thr Asn Gln Ser Gly Lys Lys Ala
     130                 135                 140

 ccg gcc tcc gtg gtc cga tgt gcc acc ctc tta cac cgc acc cct cca      480
 Pro Ala Ser Val Val Arg Cys Ala Thr Leu Leu His Arg Thr Pro Pro
 145                 150                 155                 160

 gcc acc caa acc cag acg ttc cgc act cca aat tcg gga tct ccg gcg      528
 Ala Thr Gln Thr Gln Thr Phe Arg Thr Pro Asn Ser Gly Ser Pro Ala
                 165                 170                 175

 agc aag gca acc gca gca gaa agc gct ttc agt cgg aga gta gaa ggc      576
 Ser Lys Ala Thr Ala Ala Glu Ser Ala Phe Ser Arg Arg Val Glu Gly
             180                 185                 190

 aaa gca caa aac cac ttt gaa gag acg aac agc agt tcg cag aac tcc      624
 Lys Ala Gln Asn His Phe Glu Glu Thr Asn Ser Ser Ser Gln Asn Ser
         195                 200                 205

 agc gct agg gct gag ttc ctc tgt gta ccc cct ctc ctc ttc acc ctg      672
 Ser Ala Arg Ala Glu Phe Leu Cys Val Pro Pro Leu Leu Phe Thr Leu
     210                 215                 220

 ttt ttg tct gca gac tgc att cct tcc tca gga gca ggc ctg cct ggc      720
 Phe Leu Ser Ala Asp Cys Ile Pro Ser Ser Gly Ala Gly Leu Pro Gly
 225                 230                 235                 240

 gtt cct ggc aag agg ggc aag atg ggt atg ccg gta aag att ttc cgt      768
 Val Pro Gly Lys Arg Gly Lys Met Gly Met Pro Val Lys Ile Phe Arg
                 245                 250                 255

 gtc tat tac gca gac tct agc ggg gaa ccc cac ctc cca cgg cca cgc      816
 Val Tyr Tyr Ala Asp Ser Ser Gly Glu Pro His Leu Pro Arg Pro Arg
             260                 265                 270

 tgc cct ggc cac ctg ctg cct ggc atc ttc tgc ttc tcc ccc tgc ttt      864
 Cys Pro Gly His Leu Leu Pro Gly Ile Phe Cys Phe Ser Pro Cys Phe
         275                 280                 285

 gag tgt ggg ggc cgc atg tgg ggt tgt ctg gcc aca gga cct gct gct      912
 Glu Cys Gly Gly Arg Met Trp Gly Cys Leu Ala Thr Gly Pro Ala Ala
     290                 295                 300

 ggc aca cgg cgt gac tgg ggc ctg gct ggg gct ggg gct tcc atg ggc      960
 Gly Thr Arg Arg Asp Trp Gly Leu Ala Gly Ala Gly Ala Ser Met Gly
 305                 310                 315                 320

 tct gga ccc ctc tgg ggt agc tcc tgt ctc cct gtg ggc atc agt ggc     1008
 Ser Gly Pro Leu Trp Gly Ser Ser Cys Leu Pro Val Gly Ile Ser Gly
                 325                 330                 335

 tct cca gtg cag ttc tgt gtc tgg ggg ctt ctg tct aag gga aca ctc     1056
 Ser Pro Val Gln Phe Cys Val Trp Gly Leu Leu Ser Lys Gly Thr Leu
             340                 345                 350

 agt ctc cac atc gtc ttg gtg tca tcc ggc tct gtc cag ttt gct cat     1104
 Ser Leu His Ile Val Leu Val Ser Ser Gly Ser Val Gln Phe Ala His
         355                 360                 365

 gca cac gca aag cca gag gac aat ggg gtt tat ggg cag tgc cca cag     1152
 Ala His Ala Lys Pro Glu Asp Asn Gly Val Tyr Gly Gln Cys Pro Gln
     370                 375                 380

 cag gca tga                                                         1161
 Gln Ala 
 385





      <210> 539
      <211> 1291
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (591)..(1172)

      <400> 539
 ttttaagatg tataattata tttaaaaaca agcaatgctt aattttgtgc ctgattttcc     60

 tctttaaaaa tggatttatc tgggggttgc agttgatgac gttttgattt taatatgttt    120

 gctgctgcta ccaagagctt tgtcaagcaa gttggagatg gagggagatt atttcctgtt    180

 ccaagcctca gtgaagctga ccaatatcaa cccttaagtc ttgtgggtaa aaaagaagcg    240

 atgcttctgt tcctagatat aaatttactt caacaccttt tacactgaaa gatattctcc    300

 taggagacag agaaatttca gctggtattt catcttatca attactgaat tatgaagatg    360

 aatcagatgt ttcactctat ggaaggcgag gtaaccatat tgtaaatgac gttgggatta    420

 acgttgctgg atcaaattcc attgcaggga aagcttcatt tggtatagta accaaacatg    480

 aagtggaagt atcaacatta ctcaaagaaa ttactacacg aaaaattaac tttgaccaca    540

 gcttgatacg tcagtcaagg agcagcagaa aggcagtatt gtgtgtggtc   atg gag     596
                                                          Met Glu
                                                            1

 agc atc cga acc aca cga cag tgc tca ctg tct gtg cat gct gga att      644
 Ser Ile Arg Thr Thr Arg Gln Cys Ser Leu Ser Val His Ala Gly Ile
           5                  10                  15

 cga ggg gaa gca atg cgg ttt cac ttt atg gat gaa cag aat ccc aag      692
 Arg Gly Glu Ala Met Arg Phe His Phe Met Asp Glu Gln Asn Pro Lys
      20                  25                  30

 gga agg gac aaa gct att gtt ttc cca gca cat aca acc ata gct ttc      740
 Gly Arg Asp Lys Ala Ile Val Phe Pro Ala His Thr Thr Ile Ala Phe
  35                  40                  45                  50

 agt gtt ttt gaa ctc ttc ata tac ctg gat ggt gcc ttt gac ctt tgt      788
 Ser Val Phe Glu Leu Phe Ile Tyr Leu Asp Gly Ala Phe Asp Leu Cys
                  55                  60                  65

 gtc act tca gtg tca aaa gga gga ttt gaa agg gaa gaa acg gca aca      836
 Val Thr Ser Val Ser Lys Gly Gly Phe Glu Arg Glu Glu Thr Ala Thr
              70                  75                  80

 ttt gca ctg ctg tac agg ttg aga aat atc cta ttt gaa aga aat aga      884
 Phe Ala Leu Leu Tyr Arg Leu Arg Asn Ile Leu Phe Glu Arg Asn Arg
          85                  90                  95

 aga gtg atg gat gtc att tct cgt tca cag ctt tac ttg gat gat ctt      932
 Arg Val Met Asp Val Ile Ser Arg Ser Gln Leu Tyr Leu Asp Asp Leu
     100                 105                 110

 ttt tct gac tac tat gac aaa cct ctc agc atg act gat att tca ctc      980
 Phe Ser Asp Tyr Tyr Asp Lys Pro Leu Ser Met Thr Asp Ile Ser Leu
 115                 120                 125                 130

 aaa gaa ggg acc cat atc cga gtt aac tta ctt aat cac aac att ccc     1028
 Lys Glu Gly Thr His Ile Arg Val Asn Leu Leu Asn His Asn Ile Pro
                 135                 140                 145

 aaa ggg cct tgc ata ctc tgt gga atg ggg aac ttc aaa agg gag aca     1076
 Lys Gly Pro Cys Ile Leu Cys Gly Met Gly Asn Phe Lys Arg Glu Thr
             150                 155                 160

 gtt tat ggg tgc ttt cag tgt tct gtt gat ggt cag aag tat gtg aga     1124
 Val Tyr Gly Cys Phe Gln Cys Ser Val Asp Gly Gln Lys Tyr Val Arg
         165                 170                 175

 ctt cat gca gtt cct tgt ttt gat att tgg cac aag agg atg aaa taa     1172
 Leu His Ala Val Pro Cys Phe Asp Ile Trp His Lys Arg Met Lys 
     180                 185                 190

 aatgaaaaat gaatacaccg tgttggtgtt ttaggtgcag ttgtgccaca aaccttccct   1232

 aaattatcta ggtttgcttt gatgaattaa attaaaatga gaaaagcaaa aaaaaaaaa    1291




      <210> 540
      <211> 2012
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (739)..(1050)

      <400> 540
 gggtgaaggc aaaagtgttt attcaagact ttctaccaca ctgtgggaag catcgataaa     60

 cagtcataat aattatcatt ctgagtcact gcaagcgtgg ggttggatgc tggctctcac    120

 agtagcctgt gttgggacca tgagcagcca tgcgcacctc cacgcacggc cgagctcaac    180

 ccgaagacca cgcgtgctcc ctggcaggag caggaggcct gaccacagac gcagcagctc    240

 cccagcctga gcctgggagt gcaccagcca gctcgcagcg gaggccgttt ctcctcacag    300

 gctggagtga gctcagagtc tagaggtcag aggacctcag actaagagct gcaacagaac    360

 gacagcaaga acattctgga aacgatgcca cagtgaatct tttatactgt cactcacact    420

 tggtgagggc ctcagacatg aaaccctggg gagaggcgag tgtgacctcc agagtttggc    480

 tgggatgcgg ctgagacaga cctgctgctg gccgaggagg gcagtggctg gcgtggccct    540

 catggccagc aggtgctagg actcctctgg aggcccaggc gcctgtctaa gctgccggct    600

 gtggaccacc tgcagagctc cccccgcagc ctggcggagc tgggcatcca gggcgccacg    660

 gaggtcgttc acctggacat caggcagggg gttaaggcca atgatgaccc catccctcgg    720

 ggccagctga ccctctgc  atg agg gcc aag gtc ccg ccg tcg cct ccg gag     771
                      Met Arg Ala Lys Val Pro Pro Ser Pro Pro Glu
                        1               5                  10

 gtc gga gcc agc ctg cag ttt cag gtc ccg gtt ggg ctt ggc att gtc      819
 Val Gly Ala Ser Leu Gln Phe Gln Val Pro Val Gly Leu Gly Ile Val
              15                  20                  25

 cgg cct ctg gcc ccc cgg gac agc tcg ttt gag ccc cag ctc tgg ctc      867
 Arg Pro Leu Ala Pro Arg Asp Ser Ser Phe Glu Pro Gln Leu Trp Leu
          30                  35                  40

 tgg cct ctg cct ggg ctc ctg gac agc agc gtc ctc ccc gcc tct cgg      915
 Trp Pro Leu Pro Gly Leu Leu Asp Ser Ser Val Leu Pro Ala Ser Arg
      45                  50                  55

 ctg ctc gtg gga cac agg cac atg gtc ccc ccc gcg ggc ctt tct cat      963
 Leu Leu Val Gly His Arg His Met Val Pro Pro Ala Gly Leu Ser His
  60                  65                  70                  75

 ctc cag gtg acc gcc atg gtc cag ccg gtg gcc ctg ctg tcc acc ctg     1011
 Leu Gln Val Thr Ala Met Val Gln Pro Val Ala Leu Leu Ser Thr Leu
                  80                  85                  90

 ctc gcc atc aga gat gac ccg cag ttc cgg ctg gcg taa cacagcctgg      1060
 Leu Ala Ile Arg Asp Asp Pro Gln Phe Arg Leu Ala 
              95                 100

 ggctgtgcag ctgctccttc cgccccaccg ggcaggtccg ctgcaaggcc caggtctcgg   1120

 ctcacttgct tgggcttcat gcgagggtcc cccgtctctg ctcctggccc tgccacgagc   1180

 cagttggctt ccttcagaat gctggtgcca gtggctgcca cctccttccc aggttttttc   1240

 ctgtcttggg aaccgccagt aacgtcctga ctttgcccag ggaattcctc tgcgaggcgc   1300

 tcctctgggc ccccggcttc cctggcgggg tctggcacgg gcacctgctc cgggcccttg   1360

 gggagctcct tcacagtgcc agctgccctg ggggcggcat ccttctggcc atctctcagc   1420

 ttggcctggg ctgcccgagg ctctgtgtca gggccgccgt caggagggcc agcagggtct   1480

 tctgcccaca ggcccctcag agtgctccag ggagcgctgg ttaaggtcct gggatggagc   1540

 agggcggccc ccaggagcct gcctgggttt atcctcctcg tcctcctgcc tctgctggtg   1600

 gatctccttg tgctgctcct cgatcaccgc cagcagcttc tcctgctggt ccagcaagcg   1660

 cttttgctgc acctgctgtt ctttgatcac ctgaagcagg acggcgtggt ccagcatctc   1720

 cgccctgcca gcttctgcta ctatcttttt aatttcagcc tccagctggc tggccgcctg   1780

 gtttccaccc gctcgctcca cgtccctctg ctcgcgaggc tcgggcggca gcccaggccc   1840

 tggagccggc ttctccgctg ggaggggagg cttcccaccg aggccgctgt cctctgcggg   1900

 ctgacctgtg taccagcggg tgtttgctgt acggtgatgc tactaggatc gttggtggac   1960

 accacccgga tcagcctctt gctggccaca tagcacatcc ttcacgcctt ag           2012




      <210> 541
      <211> 979
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (102)..(758)

      <400> 541
 gtttcttcag tttttggcgt ggcaatttgg caaatgttat tcggtatttt ccaacacaag     60

 ctctaaactt tgcttttaag gacaaataca agcagctatt c    atg tct gga gtt     113
                                                  Met Ser Gly Val
                                                    1

 aat aaa gaa aaa cag cat gtg gga att ctg gga gat aaa att caa gtt      161
 Asn Lys Glu Lys Gln His Val Gly Ile Leu Gly Asp Lys Ile Gln Val
   5                  10                  15                  20

 gag att tcg ttc tgg agg tgg ttt ttg gca aac ctg gct tct ggt gga      209
 Glu Ile Ser Phe Trp Arg Trp Phe Leu Ala Asn Leu Ala Ser Gly Gly
                  25                  30                  35

 gct gct ggg gca aca tcc tta tgt gta gta tat cct cta gat ttt gcc      257
 Ala Ala Gly Ala Thr Ser Leu Cys Val Val Tyr Pro Leu Asp Phe Ala
              40                  45                  50

 cga acc cga tta ggt gtc gat att gga aaa ggt cct gag gag cga caa      305
 Arg Thr Arg Leu Gly Val Asp Ile Gly Lys Gly Pro Glu Glu Arg Gln
          55                  60                  65

 ttc aag ggt tta ggt gac tgt att atg aaa ata gca aaa tca gat gga      353
 Phe Lys Gly Leu Gly Asp Cys Ile Met Lys Ile Ala Lys Ser Asp Gly
      70                  75                  80

 att gct ggt tta tac caa ggg ttt ggt gtt tca gta cag ggc atc att      401
 Ile Ala Gly Leu Tyr Gln Gly Phe Gly Val Ser Val Gln Gly Ile Ile
  85                  90                  95                 100

 gtg tac cga gcc tct tat ttt gga gct tat gac aca gtt aag ggt tta      449
 Val Tyr Arg Ala Ser Tyr Phe Gly Ala Tyr Asp Thr Val Lys Gly Leu
                 105                 110                 115

 tta cca aag cca aag aaa act cca ttt ctt gtc tcc ttt ttc att gct      497
 Leu Pro Lys Pro Lys Lys Thr Pro Phe Leu Val Ser Phe Phe Ile Ala
             120                 125                 130

 caa gtt gtg act aca tgc tct gga ata ctt tct tat ccc ttt gac aca      545
 Gln Val Val Thr Thr Cys Ser Gly Ile Leu Ser Tyr Pro Phe Asp Thr
         135                 140                 145

 gtt aga aga cgt atg atg atg cag agt ggt gag gct aaa cgg caa tat      593
 Val Arg Arg Arg Met Met Met Gln Ser Gly Glu Ala Lys Arg Gln Tyr
     150                 155                 160

 aaa gga acc tta gac tgc ttt gtg aag ata tac caa cat gaa gga atc      641
 Lys Gly Thr Leu Asp Cys Phe Val Lys Ile Tyr Gln His Glu Gly Ile
 165                 170                 175                 180

 agt tcc ttt ttt cgt ggc gcc ttc tcc aat gtt ctt cgc ggt aca ggg      689
 Ser Ser Phe Phe Arg Gly Ala Phe Ser Asn Val Leu Arg Gly Thr Gly
                 185                 190                 195

 ggt gct ttg gtg ttg gta tta tat gat aaa att aaa gaa ttc ttt cat      737
 Gly Ala Leu Val Leu Val Leu Tyr Asp Lys Ile Lys Glu Phe Phe His
             200                 205                 210

 att gat att ggt ggt agg taa tc gggagagtaa attaagaaat acatggattt      790
 Ile Asp Ile Gly Gly Arg 
         215

 aacttgttaa acatacaaat tacatagctg ccatttgcat acattttgat agtgttattg    850

 tctgtatttt gttaaagtgc tagttctgca ataaagcata cattttttca agaatttaaa    910

 tactaaaaat cagataaatg tggattttcc tcccacttag actcaaaaaa aaaaaaaaaa    970

 aaaaaattg                                                            979




      <210> 542
      <211> 531
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (1)..(531)

      <400> 542
  atg ggc cag cca gcc cca gtc ggc gcc atg gcg tct gcc gag ccc ctg      48
  Met Gly Gln Pro Ala Pro Val Gly Ala Met Ala Ser Ala Glu Pro Leu
    1               5                  10                  15

 acg gcg ctg tcc cgc tgg tac ctg tat gcc atc cac ggc tac ttc tgc       96
 Thr Ala Leu Ser Arg Trp Tyr Leu Tyr Ala Ile His Gly Tyr Phe Cys
              20                  25                  30

 gag gtg atg ttc aca gcg gcc tgg gag ttc gtg gtg aac ttg aac tgg      144
 Glu Val Met Phe Thr Ala Ala Trp Glu Phe Val Val Asn Leu Asn Trp
          35                  40                  45

 aag ttc cct ggg gtc acg agc gtg tgg gcc ctc ttc atc tac ggc acc      192
 Lys Phe Pro Gly Val Thr Ser Val Trp Ala Leu Phe Ile Tyr Gly Thr
      50                  55                  60

 tcc atc ctc atc gtg gag cgc atg tac ctg cgg ctg cgc ggc cgc tgc      240
 Ser Ile Leu Ile Val Glu Arg Met Tyr Leu Arg Leu Arg Gly Arg Cys
  65                  70                  75                  80

 ccg ctg ctc ctg cgc tgc ctc atc tac acg ctc tgg acc tac ctg tgg      288
 Pro Leu Leu Leu Arg Cys Leu Ile Tyr Thr Leu Trp Thr Tyr Leu Trp
                  85                  90                  95

 gag ttc acc acc ggc ttc atc ctg cgc cag ttc aac gcc tgc ccc tgg      336
 Glu Phe Thr Thr Gly Phe Ile Leu Arg Gln Phe Asn Ala Cys Pro Trp
             100                 105                 110

 gac tac tcc cag ttc gac ttt gac ttc atg ggc ctc atc acc ctg gag      384
 Asp Tyr Ser Gln Phe Asp Phe Asp Phe Met Gly Leu Ile Thr Leu Glu
         115                 120                 125

 tac gcc gtg ccc tgg ttc tgc ggg gcc ctc atc atg gag cag ttc atc      432
 Tyr Ala Val Pro Trp Phe Cys Gly Ala Leu Ile Met Glu Gln Phe Ile
     130                 135                 140

 atc cgc aac acc ctc cgc ctc cgc ttc gac aag gac gct gag ccc ggg      480
 Ile Arg Asn Thr Leu Arg Leu Arg Phe Asp Lys Asp Ala Glu Pro Gly
 145                 150                 155                 160

 gag ccc agc ggc gcc cta gcc ctg gcc aac ggc cat gtc aag act gac      528
 Glu Pro Ser Gly Ala Leu Ala Leu Ala Asn Gly His Val Lys Thr Asp
                 165                 170                 175

 tga                                                                  531
 






      <210> 543
      <211> 1284
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (1)..(1284)

      <400> 543
  atg gga gct tcg gac ccg gaa gtg gcg ccc tgg gct cgc ggc ggt gcc      48
  Met Gly Ala Ser Asp Pro Glu Val Ala Pro Trp Ala Arg Gly Gly Ala
    1               5                  10                  15

 gcg ggg atg gcg gga gcc gga gct gga gcc gga gct cgc ggc gga gcg       96
 Ala Gly Met Ala Gly Ala Gly Ala Gly Ala Gly Ala Arg Gly Gly Ala
              20                  25                  30

 gcg gcg ggg gtc gag gct cga gct cgc gat cca ccg ccc gcg cac cgc      144
 Ala Ala Gly Val Glu Ala Arg Ala Arg Asp Pro Pro Pro Ala His Arg
          35                  40                  45

 gca cat cct cgc cac cct cgg cct gcg gct cag ccc tcg gcc cgc agg      192
 Ala His Pro Arg His Pro Arg Pro Ala Ala Gln Pro Ser Ala Arg Arg
      50                  55                  60

 atg gat ggc ggg tca ggg ggc ctg ggg tct ggg gac aac gcc ccg acc      240
 Met Asp Gly Gly Ser Gly Gly Leu Gly Ser Gly Asp Asn Ala Pro Thr
  65                  70                  75                  80

 act gag gct ctt ttc gtg gca ctg ggc gcg ggc gtg acg gcg ctc agc      288
 Thr Glu Ala Leu Phe Val Ala Leu Gly Ala Gly Val Thr Ala Leu Ser
                  85                  90                  95

 cat ccc ctg ctc tac gtg aag ctg ctc atc cag gtg ggt cat gag ccg      336
 His Pro Leu Leu Tyr Val Lys Leu Leu Ile Gln Val Gly His Glu Pro
             100                 105                 110

 atg ccc ccc acc ctt ggg acc aat gtg ctg ggg agg aag gtc ctc tat      384
 Met Pro Pro Thr Leu Gly Thr Asn Val Leu Gly Arg Lys Val Leu Tyr
         115                 120                 125

 ctg ccg agc ttc ttc acc tac gcc aag tac atc gtg caa gtg gat ggt      432
 Leu Pro Ser Phe Phe Thr Tyr Ala Lys Tyr Ile Val Gln Val Asp Gly
     130                 135                 140

 aag ata ggg ctg ttc cga ggc ctg agt ccc cgg ctg atg tcc aac gcc      480
 Lys Ile Gly Leu Phe Arg Gly Leu Ser Pro Arg Leu Met Ser Asn Ala
 145                 150                 155                 160

 ctc tct act gtg act cgg ggt agc atg aag aag gtt ttc cct cca gat      528
 Leu Ser Thr Val Thr Arg Gly Ser Met Lys Lys Val Phe Pro Pro Asp
                 165                 170                 175

 gag att gag cag gtt tcc aac aag gat gat atg aag act tcc ctg aag      576
 Glu Ile Glu Gln Val Ser Asn Lys Asp Asp Met Lys Thr Ser Leu Lys
             180                 185                 190

 aaa gtt gtg aag gag acc tcc tac gag atg atg atg cag tgt gtg tcc      624
 Lys Val Val Lys Glu Thr Ser Tyr Glu Met Met Met Gln Cys Val Ser
         195                 200                 205

 cgc atg ttg gcc cac ccc ctg cat gtc atc tca atg cgc tgc atg gtc      672
 Arg Met Leu Ala His Pro Leu His Val Ile Ser Met Arg Cys Met Val
     210                 215                 220

 cag ttt gtg gga cgg gag gcc aag tac agt ggt gtg ctg agc tcc att      720
 Gln Phe Val Gly Arg Glu Ala Lys Tyr Ser Gly Val Leu Ser Ser Ile
 225                 230                 235                 240

 ggg aag att ttc aaa gag gaa ggg ctg ctg gga ttc ttc gtt gga tta      768
 Gly Lys Ile Phe Lys Glu Glu Gly Leu Leu Gly Phe Phe Val Gly Leu
                 245                 250                 255

 atc cct cac ctc ctg ggc gat gtg gtt ttc ttg tgg ggc tgt aac ctg      816
 Ile Pro His Leu Leu Gly Asp Val Val Phe Leu Trp Gly Cys Asn Leu
             260                 265                 270

 ctg gcc cac ttc atc aat gcc tac ctg gtg gat gac agc ttc agc cag      864
 Leu Ala His Phe Ile Asn Ala Tyr Leu Val Asp Asp Ser Phe Ser Gln
         275                 280                 285

 gcc ctg gcc atc cgg agc tat acc aag ttc gtg atg ggg att gca gtg      912
 Ala Leu Ala Ile Arg Ser Tyr Thr Lys Phe Val Met Gly Ile Ala Val
     290                 295                 300

 agc atg ctg acc tac ccc ttc ctg cta gtt ggc gac ctc atg gct gtg      960
 Ser Met Leu Thr Tyr Pro Phe Leu Leu Val Gly Asp Leu Met Ala Val
 305                 310                 315                 320

 aac aac tgc ggg ctg caa gct ggg ctc ccc cct tac tcc cca gtg ttc     1008
 Asn Asn Cys Gly Leu Gln Ala Gly Leu Pro Pro Tyr Ser Pro Val Phe
                 325                 330                 335

 aaa tcc tgg att cac tgc tgg aag tac ctg agt gtg agg gcc agc tct     1056
 Lys Ser Trp Ile His Cys Trp Lys Tyr Leu Ser Val Arg Ala Ser Ser
             340                 345                 350

 tcc gag gct cca gcc tgc ttt tcc gcc ggg tgt cat cag gat cat gct     1104
 Ser Glu Ala Pro Ala Cys Phe Ser Ala Gly Cys His Gln Asp His Ala
         355                 360                 365

 ttg ccc tgg agt aac ctg aat cat cta aaa aac acg gtc tca acc tgg     1152
 Leu Pro Trp Ser Asn Leu Asn His Leu Lys Asn Thr Val Ser Thr Trp
     370                 375                 380

 cca ccg tgg gtg agg cct gac cac ctt ggg aca cct gca aga cga ctc     1200
 Pro Pro Trp Val Arg Pro Asp His Leu Gly Thr Pro Ala Arg Arg Leu
 385                 390                 395                 400

 caa ccc aac aac aac cag atg tgc tcc agc cca gcc ggg ctt cag ttc     1248
 Gln Pro Asn Asn Asn Gln Met Cys Ser Ser Pro Ala Gly Leu Gln Phe
                 405                 410                 415

 cat att tgc cat gtg tct gtc cag atg tgg ggt tga                     1284
 His Ile Cys His Val Ser Val Gln Met Trp Gly 
             420                 425





      <210> 544
      <211> 1177
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (43)..(996)

      <400> 544
 accaaggctg ctagtgaaca gcgacgtgct gcacggaacg tc   atg aag gac caa      54
                                                  Met Lys Asp Gln
                                                    1

 cgc ctg gtt ttc cat agt aaa gtt agg tca tct ggt tat gcg tca gca      102
 Arg Leu Val Phe His Ser Lys Val Arg Ser Ser Gly Tyr Ala Ser Ala
   5                  10                  15                  20

 cca cat gta act atg ttt tca cca aag acc aac atc aag agt gag ggg      150
 Pro His Val Thr Met Phe Ser Pro Lys Thr Asn Ile Lys Ser Glu Gly
                  25                  30                  35

 aaa gga tct tca agg agc agg agc agc tgc gca cgg gag gca tac ccc      198
 Lys Gly Ser Ser Arg Ser Arg Ser Ser Cys Ala Arg Glu Ala Tyr Pro
              40                  45                  50

 gtg gag tgc gct gtg ccc acc aag ccc ggc ccc cag gtc gct gcc gcc      246
 Val Glu Cys Ala Val Pro Thr Lys Pro Gly Pro Gln Val Ala Ala Ala
          55                  60                  65

 ccc acc tgc aca cgt gta tgc tgc atc cag tac tca gga gat ggg cag      294
 Pro Thr Cys Thr Arg Val Cys Cys Ile Gln Tyr Ser Gly Asp Gly Gln
      70                  75                  80

 tgg ctg gcc tgt ggg ttg gcc aac cat ctg tta ctc gtt ttt gat gcc      342
 Trp Leu Ala Cys Gly Leu Ala Asn His Leu Leu Leu Val Phe Asp Ala
  85                  90                  95                 100

 agc ctg act ggg aca cct gct gtg ttt tca ggt cac gac ggg gca gtg      390
 Ser Leu Thr Gly Thr Pro Ala Val Phe Ser Gly His Asp Gly Ala Val
                 105                 110                 115

 aat gcc gtg tgc tgg agc cag gac cgg agg tgg ctg ctc tct gcg gcc      438
 Asn Ala Val Cys Trp Ser Gln Asp Arg Arg Trp Leu Leu Ser Ala Ala
             120                 125                 130

 cgg gac ggg acc ctg cga atg tgg tcg gct cgt ggg gca gag ctc gca      486
 Arg Asp Gly Thr Leu Arg Met Trp Ser Ala Arg Gly Ala Glu Leu Ala
         135                 140                 145

 ctg ctt ctg ata gac atg acc agt tta tcg gca gtc aac gac ttt tat      534
 Leu Leu Leu Ile Asp Met Thr Ser Leu Ser Ala Val Asn Asp Phe Tyr
     150                 155                 160

 tcc cac atc gta ctc gca gct ggc cgg aac agg acc gtg gaa gtg ttt      582
 Ser His Ile Val Leu Ala Ala Gly Arg Asn Arg Thr Val Glu Val Phe
 165                 170                 175                 180

 gac ctc aac gcc ggc tgc agt gca gcg gtg ata gcg gaa gcc cac tca      630
 Asp Leu Asn Ala Gly Cys Ser Ala Ala Val Ile Ala Glu Ala His Ser
                 185                 190                 195

 cgg cct gtc cat caa atc tgc caa aat aaa gtt tca tca ttt aca tcc      678
 Arg Pro Val His Gln Ile Cys Gln Asn Lys Val Ser Ser Phe Thr Ser
             200                 205                 210

 gaa ggg cat cca acc tat aac cta tcc atg agg acg gcc att gtg tgg      726
 Glu Gly His Pro Thr Tyr Asn Leu Ser Met Arg Thr Ala Ile Val Trp
         215                 220                 225

 gac ctg aga acc ctg agg tgt gag cgc cac ttt gaa ggg cat cca acc      774
 Asp Leu Arg Thr Leu Arg Cys Glu Arg His Phe Glu Gly His Pro Thr
     230                 235                 240

 cgc ggc tat cca tgt gga atc gct ttc agt cct tgt gga cga ttc gcg      822
 Arg Gly Tyr Pro Cys Gly Ile Ala Phe Ser Pro Cys Gly Arg Phe Ala
 245                 250                 255                 260

 gct tgt ggg gcc gag gac aga cac gct tac gtg tat gaa atg ggc tca      870
 Ala Cys Gly Ala Glu Asp Arg His Ala Tyr Val Tyr Glu Met Gly Ser
                 265                 270                 275

 agc acg ttt tct cac cgg ctg gct ggg cac aca gac act gtc act gga      918
 Ser Thr Phe Ser His Arg Leu Ala Gly His Thr Asp Thr Val Thr Gly
             280                 285                 290

 gtg gcc ttc aac cca tca gcg ccc cag ctt gcc aca gct acc ttg gat      966
 Val Ala Phe Asn Pro Ser Ala Pro Gln Leu Ala Thr Ala Thr Leu Asp
         295                 300                 305

 ggt aaa ctc cag ctc ttt cta gct gag taa c cactgacctg tgagctgggt     1017
 Gly Lys Leu Gln Leu Phe Leu Ala Glu 
     310                 315

 ccaggaatgc tgtgaggaac aacttaaaag taagaagtag tggttcatcc atcagggggc   1077

 cagaagcagc aactgttttt catattttga gacttgcctc agatttcccc cgtttgcaag   1137

 ctcctcccct ctgtgtgtgc catgtcagag ttttatgtct                         1177




      <210> 545
      <211> 4345
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (23)..(4345)

      <400> 545
 atgactgtca atccagggga ag atg atg gtg gaa gct gtg aag gtg ttg aca      52
                          Met Met Val Glu Ala Val Lys Val Leu Thr
                            1               5                  10

 agc agt tca gat cct gga cat att tta aag ata aac cca cag gac ata      100
 Ser Ser Ser Asp Pro Gly His Ile Leu Lys Ile Asn Pro Gln Asp Ile
                  15                  20                  25

 caa gtg tgc ccc agc ctg gat att cgc tca gag gtg gca gag ctt cgt      148
 Gln Val Cys Pro Ser Leu Asp Ile Arg Ser Glu Val Ala Glu Leu Arg
              30                  35                  40

 cag ctg gag aac tgc agc gtg gtg gag ggc cac ctg cag atc ctg ctc      196
 Gln Leu Glu Asn Cys Ser Val Val Glu Gly His Leu Gln Ile Leu Leu
          45                  50                  55

 atg ttc aca gcc acc ggg gag gac ttc cgc ggc ctc agc ttc cct cgc      244
 Met Phe Thr Ala Thr Gly Glu Asp Phe Arg Gly Leu Ser Phe Pro Arg
      60                  65                  70

 ctc acc cag gtc acc gac tac ctg ctg ctc ttc cgt gtc tac gga ctg      292
 Leu Thr Gln Val Thr Asp Tyr Leu Leu Leu Phe Arg Val Tyr Gly Leu
  75                  80                  85                  90

 gag agc ctg cgc gac ctc ttc ccc aac cta gca gtc atc cgc ggg acg      340
 Glu Ser Leu Arg Asp Leu Phe Pro Asn Leu Ala Val Ile Arg Gly Thr
                  95                 100                 105

 cgc ctc ttc ctg ggc tat gca ctg gtc atc ttt gag atg cca cat ctg      388
 Arg Leu Phe Leu Gly Tyr Ala Leu Val Ile Phe Glu Met Pro His Leu
             110                 115                 120

 cgt gac gtg gca ctg cct gca ctt ggg gcc gtg ctg cgt ggg gct gtg      436
 Arg Asp Val Ala Leu Pro Ala Leu Gly Ala Val Leu Arg Gly Ala Val
         125                 130                 135

 cgt gtg gag aag aac cag gag ctc tgc cac ctc tcc acc att gac tgg      484
 Arg Val Glu Lys Asn Gln Glu Leu Cys His Leu Ser Thr Ile Asp Trp
     140                 145                 150

 gga ctg ctg cag cca gca cct ggc gcc aac cac atc gtg ggc aac aag      532
 Gly Leu Leu Gln Pro Ala Pro Gly Ala Asn His Ile Val Gly Asn Lys
 155                 160                 165                 170

 ctg ggc gag gag tgt gct gac gtg tgc cct ggt gtg ctg ggt gct gct      580
 Leu Gly Glu Glu Cys Ala Asp Val Cys Pro Gly Val Leu Gly Ala Ala
                 175                 180                 185

 ggt gag ccc tgt gcc aag acc acc ttc agc ggg cac act gac tac aga      628
 Gly Glu Pro Cys Ala Lys Thr Thr Phe Ser Gly His Thr Asp Tyr Arg
             190                 195                 200

 tgc tgg acc tcc agc cac tgc cag aga gtg tgc ccc tgc ccc cat ggg      676
 Cys Trp Thr Ser Ser His Cys Gln Arg Val Cys Pro Cys Pro His Gly
         205                 210                 215

 atg gct tgc aca gcg agg ggc gag tgc tgc cac acc gaa tgc ctg ggg      724
 Met Ala Cys Thr Ala Arg Gly Glu Cys Cys His Thr Glu Cys Leu Gly
     220                 225                 230

 ggc tgc agc cag cca gaa gac cct cgt gcc tgt gta gct tgc cgc cac      772
 Gly Cys Ser Gln Pro Glu Asp Pro Arg Ala Cys Val Ala Cys Arg His
 235                 240                 245                 250

 ctc tac ttc cag ggt gcc tgc ctg tgg gcc tgc ccg cca ggc acc tac      820
 Leu Tyr Phe Gln Gly Ala Cys Leu Trp Ala Cys Pro Pro Gly Thr Tyr
                 255                 260                 265

 cag tat gag tcc tgg cgc tgt gtc aca gct gag cgc tgt gcc agc ctg      868
 Gln Tyr Glu Ser Trp Arg Cys Val Thr Ala Glu Arg Cys Ala Ser Leu
             270                 275                 280

 cac tct gtg ccc ggc cgt gcc tcc acc ttc ggc ata cac cag ggc agt      916
 His Ser Val Pro Gly Arg Ala Ser Thr Phe Gly Ile His Gln Gly Ser
         285                 290                 295

 tgc ctg gcc cag tgc cct tct ggc ttc acc cgt aat agc agc agc ata      964
 Cys Leu Ala Gln Cys Pro Ser Gly Phe Thr Arg Asn Ser Ser Ser Ile
     300                 305                 310

 ttc tgc cac aag tgc gag ggg ctg tgc cct aaa gag tgc aag gta ggc     1012
 Phe Cys His Lys Cys Glu Gly Leu Cys Pro Lys Glu Cys Lys Val Gly
 315                 320                 325                 330

 acc aag acc atc gac tcc atc cag gcg gca cag gat ctt gtg ggc tgc     1060
 Thr Lys Thr Ile Asp Ser Ile Gln Ala Ala Gln Asp Leu Val Gly Cys
                 335                 340                 345

 acg cat gtg gag gga agc ctc atc ctc aac ctt cgc cag ggc tac aac     1108
 Thr His Val Glu Gly Ser Leu Ile Leu Asn Leu Arg Gln Gly Tyr Asn
             350                 355                 360

 ctg gag cca cag ctg cag cac agc ctg ggg ctg gta gaa acc att act     1156
 Leu Glu Pro Gln Leu Gln His Ser Leu Gly Leu Val Glu Thr Ile Thr
         365                 370                 375

 ggc ttc ctc aaa atc aag cac tcc ttt gcc ctc gtg tcc ctg ggc ttt     1204
 Gly Phe Leu Lys Ile Lys His Ser Phe Ala Leu Val Ser Leu Gly Phe
     380                 385                 390

 ttc aag aac ctc aaa cta atc cgg gga gac gcc atg gtg gat ggg aac     1252
 Phe Lys Asn Leu Lys Leu Ile Arg Gly Asp Ala Met Val Asp Gly Asn
 395                 400                 405                 410

 tac act ctc tac gtg ctg gac aac cag aac cta caa cag cta ggg tcc     1300
 Tyr Thr Leu Tyr Val Leu Asp Asn Gln Asn Leu Gln Gln Leu Gly Ser
                 415                 420                 425

 tgg gtg gcc gcg ggg ctc acc att ccc gtg ggc aag atc tac ttc gcc     1348
 Trp Val Ala Ala Gly Leu Thr Ile Pro Val Gly Lys Ile Tyr Phe Ala
             430                 435                 440

 ttc aac ccg cgc ctc tgc ttg gaa cac atc tac cga ctg gag gag gtg     1396
 Phe Asn Pro Arg Leu Cys Leu Glu His Ile Tyr Arg Leu Glu Glu Val
         445                 450                 455

 aca ggc acg cga ggt cgg cag aac aag gct gag atc aac ccc cgc acc     1444
 Thr Gly Thr Arg Gly Arg Gln Asn Lys Ala Glu Ile Asn Pro Arg Thr
     460                 465                 470

 aac gga gac cgc gcc gcc tgc cag act cgc acc ctg cgc ttc gtg tcc     1492
 Asn Gly Asp Arg Ala Ala Cys Gln Thr Arg Thr Leu Arg Phe Val Ser
 475                 480                 485                 490

 aac gtg acg gag gca gac cgc atc ctg cta cgc tgg gag cgc tat gag     1540
 Asn Val Thr Glu Ala Asp Arg Ile Leu Leu Arg Trp Glu Arg Tyr Glu
                 495                 500                 505

 cca ctg gag gcc cgc gac ctg ctc agc ttc atc gtg tac tac aag gag     1588
 Pro Leu Glu Ala Arg Asp Leu Leu Ser Phe Ile Val Tyr Tyr Lys Glu
             510                 515                 520

 tcc cca ttc cag aac gcc aca gag cac gtg ggt cca gat gct tgt gga     1636
 Ser Pro Phe Gln Asn Ala Thr Glu His Val Gly Pro Asp Ala Cys Gly
         525                 530                 535

 acc cag agc tgg aac ctg ctg gat gtg gag ctg ccc cta agc cgc acc     1684
 Thr Gln Ser Trp Asn Leu Leu Asp Val Glu Leu Pro Leu Ser Arg Thr
     540                 545                 550

 cag gag cca ggg gtg acc cta gcc tcc ctc aag cct tgg aca cag tac     1732
 Gln Glu Pro Gly Val Thr Leu Ala Ser Leu Lys Pro Trp Thr Gln Tyr
 555                 560                 565                 570

 gca gtg ttt gtg cgg gcc atc acg cta acc act gag gag gac agc cct     1780
 Ala Val Phe Val Arg Ala Ile Thr Leu Thr Thr Glu Glu Asp Ser Pro
                 575                 580                 585

 cat caa gga gcc cag agt ccc atc gtc tac ctc cga acg ctg cct gca     1828
 His Gln Gly Ala Gln Ser Pro Ile Val Tyr Leu Arg Thr Leu Pro Ala
             590                 595                 600

 gct ccc acg gtg ccc caa gac gtc atc tcc acg tcc aac tcc tcc tcc     1876
 Ala Pro Thr Val Pro Gln Asp Val Ile Ser Thr Ser Asn Ser Ser Ser
         605                 610                 615

 cac ctc ctg gtg cgc tgg aag cca ccg acc cag cgc aat ggg aac ctc     1924
 His Leu Leu Val Arg Trp Lys Pro Pro Thr Gln Arg Asn Gly Asn Leu
     620                 625                 630

 acc tac tac ctg gtg ctg tgg cag cgg ctg gca gag gac ggc gac ctc     1972
 Thr Tyr Tyr Leu Val Leu Trp Gln Arg Leu Ala Glu Asp Gly Asp Leu
 635                 640                 645                 650

 tac ctc aat gac tac tgc cac cgc ggc ttg cgg ctg ccc acc agc aac     2020
 Tyr Leu Asn Asp Tyr Cys His Arg Gly Leu Arg Leu Pro Thr Ser Asn
                 655                 660                 665

 aac gat ccg cgc ttc gac ggc gaa gac ggg gat cct gag gcc gag atg     2068
 Asn Asp Pro Arg Phe Asp Gly Glu Asp Gly Asp Pro Glu Ala Glu Met
             670                 675                 680

 gag tcc gac tgc tgc cct tgc cag cac cca cct cct ggt cag gtt ctg     2116
 Glu Ser Asp Cys Cys Pro Cys Gln His Pro Pro Pro Gly Gln Val Leu
         685                 690                 695

 ccc ccg ctg gag gcg caa gag gcc tcg ttc cag aag aag ttt gaa aac     2164
 Pro Pro Leu Glu Ala Gln Glu Ala Ser Phe Gln Lys Lys Phe Glu Asn
     700                 705                 710

 ttt cta cac aac gcg atc acc atc ccc ata tcc cct tgg aag gtg acg     2212
 Phe Leu His Asn Ala Ile Thr Ile Pro Ile Ser Pro Trp Lys Val Thr
 715                 720                 725                 730

 tcc atc aac aag agc ccc caa agg gac tca ggg cgg cac cgc cgg gca     2260
 Ser Ile Asn Lys Ser Pro Gln Arg Asp Ser Gly Arg His Arg Arg Ala
                 735                 740                 745

 gct ggg ccc ctc cgg ctg ggg ggc aac agc tcg gat ttc gag atc cag     2308
 Ala Gly Pro Leu Arg Leu Gly Gly Asn Ser Ser Asp Phe Glu Ile Gln
             750                 755                 760

 gag gac aag gtg ccc cgt gag cga gcg gtg ctg agc ggc ctg cgc cac     2356
 Glu Asp Lys Val Pro Arg Glu Arg Ala Val Leu Ser Gly Leu Arg His
         765                 770                 775

 ttc acg gaa tac cgg atc gac atc cat gcc tgc aac cac gcg gcg cac     2404
 Phe Thr Glu Tyr Arg Ile Asp Ile His Ala Cys Asn His Ala Ala His
     780                 785                 790

 acc gtg ggc tgc agc gcc gcc acc ttc gtc ttt gcg cgc acc atg ccc     2452
 Thr Val Gly Cys Ser Ala Ala Thr Phe Val Phe Ala Arg Thr Met Pro
 795                 800                 805                 810

 cac aga gag gct gat ggt att cca gga aag gtg gcc tgg gag gcc tcc     2500
 His Arg Glu Ala Asp Gly Ile Pro Gly Lys Val Ala Trp Glu Ala Ser
                 815                 820                 825

 agc aag aac agt gtc ctt ctg cgc tgg ctc gag cca cca gac ccc aac     2548
 Ser Lys Asn Ser Val Leu Leu Arg Trp Leu Glu Pro Pro Asp Pro Asn
             830                 835                 840

 gga ctc atc ctc aag tac gaa atc aag tac cgc cgc ttg gga gag cca     2596
 Gly Leu Ile Leu Lys Tyr Glu Ile Lys Tyr Arg Arg Leu Gly Glu Pro
         845                 850                 855

 gct gtt ctg cgt tac tct cag gag gcc aca gtg ctg tgt gtg tcc cgt     2644
 Ala Val Leu Arg Tyr Ser Gln Glu Ala Thr Val Leu Cys Val Ser Arg
     860                 865                 870

 ctt cga tat gcg aag ttt ggg gga gtc cac ctg gcc ctg ctg ccc cct     2692
 Leu Arg Tyr Ala Lys Phe Gly Gly Val His Leu Ala Leu Leu Pro Pro
 875                 880                 885                 890

 gga aac tac tct gcc agg gtt agg gca acc tca ctg gct ggc aat ggc     2740
 Gly Asn Tyr Ser Ala Arg Val Arg Ala Thr Ser Leu Ala Gly Asn Gly
                 895                 900                 905

 tct tgg aca gac agt gtt gcc ttc tac atc ctt ggc cca gag gag gag     2788
 Ser Trp Thr Asp Ser Val Ala Phe Tyr Ile Leu Gly Pro Glu Glu Glu
             910                 915                 920

 gat gct ggg ggg ctg cat gtc ctc ctc act gcc acc cct gtg ggg ctc     2836
 Asp Ala Gly Gly Leu His Val Leu Leu Thr Ala Thr Pro Val Gly Leu
         925                 930                 935

 acg ctg ctc atc gtt ctt gct gcc ctt ggt ttc ttc tac ggc aag aag     2884
 Thr Leu Leu Ile Val Leu Ala Ala Leu Gly Phe Phe Tyr Gly Lys Lys
     940                 945                 950

 aga aac aga acc ctg tat gct tct gtg aat cca gag tac ttc agc gcc     2932
 Arg Asn Arg Thr Leu Tyr Ala Ser Val Asn Pro Glu Tyr Phe Ser Ala
 955                 960                 965                 970

 tct gat atg tat gtc cct gat gaa tgg gag gtg cct cgg gag cag atc     2980
 Ser Asp Met Tyr Val Pro Asp Glu Trp Glu Val Pro Arg Glu Gln Ile
                 975                 980                 985

 tcg ata atc cgg gaa ctg ggc cag ggc tct ttt ggg atg gta tat gag     3028
 Ser Ile Ile Arg Glu Leu Gly Gln Gly Ser Phe Gly Met Val Tyr Glu
             990                 995                1000

 ggg ctg gca cga gga ctt gag gct gga gag gag tcc aca ccc gtg gcc     3076
 Gly Leu Ala Arg Gly Leu Glu Ala Gly Glu Glu Ser Thr Pro Val Ala
        1005                1010                1015

 ctg aag acg gtg aat gag ctg gcc agc cca cgg gaa tgc att gag ttc     3124
 Leu Lys Thr Val Asn Glu Leu Ala Ser Pro Arg Glu Cys Ile Glu Phe
    1020                1025                1030

 ctc aag gaa gct tct gtc atg aaa gcc ttc aag tgt cac cat gtg gtg     3172
 Leu Lys Glu Ala Ser Val Met Lys Ala Phe Lys Cys His His Val Val
1035                1040                1045                1050

 cgt ctc ctg ggt gtg gta tct cag ggc cag cca act ctg gtc atc atg     3220
 Arg Leu Leu Gly Val Val Ser Gln Gly Gln Pro Thr Leu Val Ile Met
                1055                1060                1065

 gag tta atg acc cgt ggg gac ctc aag agc cat ctt cga tct ttg cgg     3268
 Glu Leu Met Thr Arg Gly Asp Leu Lys Ser His Leu Arg Ser Leu Arg
            1070                1075                1080

 cct gag gca gag aac aac cct ggg ctc cca cag cca gca ttg ggg gaa     3316
 Pro Glu Ala Glu Asn Asn Pro Gly Leu Pro Gln Pro Ala Leu Gly Glu
        1085                1090                1095

 atg atc caa atg gct ggt gag att gca gac ggc atg gcc tac ctt gct     3364
 Met Ile Gln Met Ala Gly Glu Ile Ala Asp Gly Met Ala Tyr Leu Ala
    1100                1105                1110

 gcc aac aag ttt gtg cac cga gat cta gca gcc cgc aac tgc atg gtg     3412
 Ala Asn Lys Phe Val His Arg Asp Leu Ala Ala Arg Asn Cys Met Val
1115                1120                1125                1130

 tcc cag gac ttc acc gtc aag atc ggg ggt aca gag gac ttc ggg atg     3460
 Ser Gln Asp Phe Thr Val Lys Ile Gly Gly Thr Glu Asp Phe Gly Met
                1135                1140                1145

 act cgg gac gtg tat gag aca gac tat tac cgc aag ggt ggg aag ggg     3508
 Thr Arg Asp Val Tyr Glu Thr Asp Tyr Tyr Arg Lys Gly Gly Lys Gly
            1150                1155                1160

 ctg ctg ccc gtg cgc tgg atg gcc ccc gag tcc ctc aaa gat ggg atc     3556
 Leu Leu Pro Val Arg Trp Met Ala Pro Glu Ser Leu Lys Asp Gly Ile
        1165                1170                1175

 ttc acc acc cac tcg gat gtc tgg tcc ttt ggc gtg gta ctc tgg gag     3604
 Phe Thr Thr His Ser Asp Val Trp Ser Phe Gly Val Val Leu Trp Glu
    1180                1185                1190

 att gtg acc ctg gca gaa caa ccc tac cag ggc ctg tcc aat gag cag     3652
 Ile Val Thr Leu Ala Glu Gln Pro Tyr Gln Gly Leu Ser Asn Glu Gln
1195                1200                1205                1210

 gtg ctg aag ttc gtc atg gat ggc ggg gtc ctg gag gag ctg gag ggc     3700
 Val Leu Lys Phe Val Met Asp Gly Gly Val Leu Glu Glu Leu Glu Gly
                1215                1220                1225

 tgt ccc ctt cag ctg cag gag ctg atg agc cgc tgc tgg cag ccg aac     3748
 Cys Pro Leu Gln Leu Gln Glu Leu Met Ser Arg Cys Trp Gln Pro Asn
            1230                1235                1240

 cca cgc ctg cgc cca tct ttc aca cac att ctg gac agc ata cag gag     3796
 Pro Arg Leu Arg Pro Ser Phe Thr His Ile Leu Asp Ser Ile Gln Glu
        1245                1250                1255

 gag ctg cgg ccc tcc ttc cgc ctc ctc tcc ttc tac tac agc ccg gaa     3844
 Glu Leu Arg Pro Ser Phe Arg Leu Leu Ser Phe Tyr Tyr Ser Pro Glu
    1260                1265                1270

 tgc cgg ggg gcc cgg ggc tcc ctg cct acc acc gat gca gag cct gac     3892
 Cys Arg Gly Ala Arg Gly Ser Leu Pro Thr Thr Asp Ala Glu Pro Asp
1275                1280                1285                1290

 tcc tca ccc act cca aga gac tgc agc cct caa aat ggg gtg ccg att     3940
 Ser Ser Pro Thr Pro Arg Asp Cys Ser Pro Gln Asn Gly Val Pro Ile
                1295                1300                1305

 gtc tgg atg tgg aag agc tta agg aag gga ttg gaa gtc gaa gaa aag     3988
 Val Trp Met Trp Lys Ser Leu Arg Lys Gly Leu Glu Val Glu Glu Lys
            1310                1315                1320

 agg gct tca gaa ata tgc cat cgc ggc tgc acc tgc aaa gat ggg cag     4036
 Arg Ala Ser Glu Ile Cys His Arg Gly Cys Thr Cys Lys Asp Gly Gln
        1325                1330                1335

 gtg gtg tct ggc cca gaa gta ctt ctg ggg gaa gaa tgc tct ggc tac     4084
 Val Val Ser Gly Pro Glu Val Leu Leu Gly Glu Glu Cys Ser Gly Tyr
    1340                1345                1350

 gga gca gag agt ggt tcc tgg ctg tca cca agt agg aag aag aat ggg     4132
 Gly Ala Glu Ser Gly Ser Trp Leu Ser Pro Ser Arg Lys Lys Asn Gly
1355                1360                1365                1370

 gta caa gga cat gag agc tca gct tcc gac acc tgc tca tac caa cgt     4180
 Val Gln Gly His Glu Ser Ser Ala Ser Asp Thr Cys Ser Tyr Gln Arg
                1375                1380                1385

 gtt tta tcc cgc ccc ata ata cca agc tcc aag tcc cag gga gct tgg     4228
 Val Leu Ser Arg Pro Ile Ile Pro Ser Ser Lys Ser Gln Gly Ala Trp
            1390                1395                1400

 atg gaa gag tac cag gtc tta gat gtc caa cca agg ggc agt cct gga     4276
 Met Glu Glu Tyr Gln Val Leu Asp Val Gln Pro Arg Gly Ser Pro Gly
        1405                1410                1415

 gta gac act ttg gac ctt gcc ctt ggc cca gtg tgg acg cac tgt gga     4324
 Val Asp Thr Leu Asp Leu Ala Leu Gly Pro Val Trp Thr His Cys Gly
    1420                1425                1430

 agc tcc tcc cct ggt cca tga                                         4345
 Ser Ser Ser Pro Gly Pro 
1435                1440





      <210> 546
      <211> 9350
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (35)..(6661)

      <400> 546
 accgcgtccg gatttcccgg gtcgacgatt tcgt    atg gtt atc agg tgc ctt      52
                                          Met Val Ile Arg Cys Leu
                                            1               5

 cca cag agg gaa ctg gac tgc gac aga ggg aac tgg act gcg acg tct      100
 Pro Gln Arg Glu Leu Asp Cys Asp Arg Gly Asn Trp Thr Ala Thr Ser
              10                  15                  20

 gct gaa ctc acg gga atc aaa tgg cgt agg tac aat ttt gga ggg cat      148
 Ala Glu Leu Thr Gly Ile Lys Trp Arg Arg Tyr Asn Phe Gly Gly His
          25                  30                  35

 ggg gac tgt gga ccc ata att tca gcc cca gcc caa gat gat cca att      196
 Gly Asp Cys Gly Pro Ile Ile Ser Ala Pro Ala Gln Asp Asp Pro Ile
      40                  45                  50

 ctg tta agt ttc atc cgc tgt ctg caa gct aac ctg ctt tgt gta tgg      244
 Leu Leu Ser Phe Ile Arg Cys Leu Gln Ala Asn Leu Leu Cys Val Trp
  55                  60                  65                  70

 cgt cgt gat gtc aaa cca gat tgc aaa gag tta tgg ata ttc tgg tgg      292
 Arg Arg Asp Val Lys Pro Asp Cys Lys Glu Leu Trp Ile Phe Trp Trp
                  75                  80                  85

 gga gat gaa ccc aac cta gtg ggt gta ata cat cat gaa ctg cag gtt      340
 Gly Asp Glu Pro Asn Leu Val Gly Val Ile His His Glu Leu Gln Val
              90                  95                 100

 gtg gaa gaa gga ctc tgg gaa aat ggc ctt tcc tat gaa tgt agg acg      388
 Val Glu Glu Gly Leu Trp Glu Asn Gly Leu Ser Tyr Glu Cys Arg Thr
         105                 110                 115

 ctg ctc ttc aaa gcg atc cac aat ctg tta gaa agg tgc cta atg gat      436
 Leu Leu Phe Lys Ala Ile His Asn Leu Leu Glu Arg Cys Leu Met Asp
     120                 125                 130

 aag aac ttc gtt agg att ggg aaa tgg ttt gtc cga ccc tac gaa aag      484
 Lys Asn Phe Val Arg Ile Gly Lys Trp Phe Val Arg Pro Tyr Glu Lys
 135                 140                 145                 150

 gat gaa aag cca gtc aac aaa agt gag cat ttg tcc tgt gct ttc aca      532
 Asp Glu Lys Pro Val Asn Lys Ser Glu His Leu Ser Cys Ala Phe Thr
                 155                 160                 165

 ttc ttt ctg cat gga gaa agt aat gta tgc aca agt gtg gag att gcc      580
 Phe Phe Leu His Gly Glu Ser Asn Val Cys Thr Ser Val Glu Ile Ala
             170                 175                 180

 cag cac cag cca att tat ttg atc aat gag gag cat ata cac atg gct      628
 Gln His Gln Pro Ile Tyr Leu Ile Asn Glu Glu His Ile His Met Ala
         185                 190                 195

 cag tct tca cct gca cca ttt caa gta ctg gta agt cct tat ggc tta      676
 Gln Ser Ser Pro Ala Pro Phe Gln Val Leu Val Ser Pro Tyr Gly Leu
     200                 205                 210

 aat ggg acg cta aca ggc caa gca tac aag atg tca gac cca gcc act      724
 Asn Gly Thr Leu Thr Gly Gln Ala Tyr Lys Met Ser Asp Pro Ala Thr
 215                 220                 225                 230

 cgt aag ttg att gag gaa tgg cag tat ttc tac ccg atg gtg cta aaa      772
 Arg Lys Leu Ile Glu Glu Trp Gln Tyr Phe Tyr Pro Met Val Leu Lys
                 235                 240                 245

 aaa aaa gaa gaa tcg aaa gag gaa gac gag ttg gga tat gat gat gat      820
 Lys Lys Glu Glu Ser Lys Glu Glu Asp Glu Leu Gly Tyr Asp Asp Asp
             250                 255                 260

 ttc cct gtg gca gtt gaa gta att gtt ggt ggt gtt cgg atg gtt tac      868
 Phe Pro Val Ala Val Glu Val Ile Val Gly Gly Val Arg Met Val Tyr
         265                 270                 275

 cct tca gca ttt gtt ttg atc tct cag aat gac atc ccg gtt cct cag      916
 Pro Ser Ala Phe Val Leu Ile Ser Gln Asn Asp Ile Pro Val Pro Gln
     280                 285                 290

 agt gtt gcc agt gct gga ggc cac att gca gtt ggg cag caa ggg ctt      964
 Ser Val Ala Ser Ala Gly Gly His Ile Ala Val Gly Gln Gln Gly Leu
 295                 300                 305                 310

 ggt agt gtg aag gac cca agt aac tgt ggg atg cct ctg acc cct ccc     1012
 Gly Ser Val Lys Asp Pro Ser Asn Cys Gly Met Pro Leu Thr Pro Pro
                 315                 320                 325

 acc tct cca gaa cag gct atc cta ggt gag agt gga ggt atg cag agt     1060
 Thr Ser Pro Glu Gln Ala Ile Leu Gly Glu Ser Gly Gly Met Gln Ser
             330                 335                 340

 gct gcc agt cac ctg gtt tcc caa gat gga ggg atg ata acg atg cac     1108
 Ala Ala Ser His Leu Val Ser Gln Asp Gly Gly Met Ile Thr Met His
         345                 350                 355

 agt cca aag aga tcg ggg aag att cct cca aaa ctc cac aat cat atg     1156
 Ser Pro Lys Arg Ser Gly Lys Ile Pro Pro Lys Leu His Asn His Met
     360                 365                 370

 gtc cat cga gtc tgg aag gaa tgc atc ctc aac aga acc cag tcc aag     1204
 Val His Arg Val Trp Lys Glu Cys Ile Leu Asn Arg Thr Gln Ser Lys
 375                 380                 385                 390

 agg agc caa atg tca act cca act ctt gaa gaa gag cct gct agc aat     1252
 Arg Ser Gln Met Ser Thr Pro Thr Leu Glu Glu Glu Pro Ala Ser Asn
                 395                 400                 405

 cct gct act tgg gat ttt gtg gat cca acc caa aga gtc agc tgt tct     1300
 Pro Ala Thr Trp Asp Phe Val Asp Pro Thr Gln Arg Val Ser Cys Ser
             410                 415                 420

 tgt tcc agg cat aag ctt tta aaa cgt tgt gca gtc ggg ccc aat cga     1348
 Cys Ser Arg His Lys Leu Leu Lys Arg Cys Ala Val Gly Pro Asn Arg
         425                 430                 435

 cct ccc aca gta tct caa cca ggg ttc agt gca gga cca tca tca tct     1396
 Pro Pro Thr Val Ser Gln Pro Gly Phe Ser Ala Gly Pro Ser Ser Ser
     440                 445                 450

 tca tct tta cca cct cct gct tct tct aag cac aaa aca gca gaa aga     1444
 Ser Ser Leu Pro Pro Pro Ala Ser Ser Lys His Lys Thr Ala Glu Arg
 455                 460                 465                 470

 cag gaa aaa gga gac aag ctg caa aag aga ccc tta ata cca ttt cac     1492
 Gln Glu Lys Gly Asp Lys Leu Gln Lys Arg Pro Leu Ile Pro Phe His
                 475                 480                 485

 cat agg ccc tct gtg gcc gaa gaa tta tgc atg gag caa gat aca cca     1540
 His Arg Pro Ser Val Ala Glu Glu Leu Cys Met Glu Gln Asp Thr Pro
             490                 495                 500

 gga cag aaa cta ggg ttg gca ggg ata gac tcc tcc tta gag gtg tct     1588
 Gly Gln Lys Leu Gly Leu Ala Gly Ile Asp Ser Ser Leu Glu Val Ser
         505                 510                 515

 agc agt agg aaa tat gat aag caa atg gcc gtg cct tcc aga aat aca     1636
 Ser Ser Arg Lys Tyr Asp Lys Gln Met Ala Val Pro Ser Arg Asn Thr
     520                 525                 530

 agc aag caa atg aat ctg aat cct atg gat tca cct cat tcc cct ata     1684
 Ser Lys Gln Met Asn Leu Asn Pro Met Asp Ser Pro His Ser Pro Ile
 535                 540                 545                 550

 tcc cct ctg cca cca aca ctc agc cct cag cca cga ggt cag gaa aca     1732
 Ser Pro Leu Pro Pro Thr Leu Ser Pro Gln Pro Arg Gly Gln Glu Thr
                 555                 560                 565

 gag agt ttg gac cca cca tcg gtc cct gtg aat cca gcc ctt tat gga     1780
 Glu Ser Leu Asp Pro Pro Ser Val Pro Val Asn Pro Ala Leu Tyr Gly
             570                 575                 580

 aat gga cta gaa ctc cag cag ttg tct act ctg gat gac aga act gtc     1828
 Asn Gly Leu Glu Leu Gln Gln Leu Ser Thr Leu Asp Asp Arg Thr Val
         585                 590                 595

 ctc gta ggc caa aga ctg cct ctc atg gca gag gtc agc gag aca gcc     1876
 Leu Val Gly Gln Arg Leu Pro Leu Met Ala Glu Val Ser Glu Thr Ala
     600                 605                 610

 tta tat tgt ggg att agg ccc tcg aac ccg gag tca tca gaa aag tgg     1924
 Leu Tyr Cys Gly Ile Arg Pro Ser Asn Pro Glu Ser Ser Glu Lys Trp
 615                 620                 625                 630

 tgg cat agt tat cgt ctc cca ccc agt gat gat gct gag ttc agg cct     1972
 Trp His Ser Tyr Arg Leu Pro Pro Ser Asp Asp Ala Glu Phe Arg Pro
                 635                 640                 645

 cca gag ctc cag ggt gag aga tgt gat gcc aaa atg gag gta aac tca     2020
 Pro Glu Leu Gln Gly Glu Arg Cys Asp Ala Lys Met Glu Val Asn Ser
             650                 655                 660

 gag agc act gca ttg caa aga ctc tta gca caa cct aac aaa cgg ttt     2068
 Glu Ser Thr Ala Leu Gln Arg Leu Leu Ala Gln Pro Asn Lys Arg Phe
         665                 670                 675

 aaa atc tgg caa gac aaa cag ccc cag ttg cag cca ctc cac ttc ctt     2116
 Lys Ile Trp Gln Asp Lys Gln Pro Gln Leu Gln Pro Leu His Phe Leu
     680                 685                 690

 gac cca ttg cct cta tca caa caa cct gga gac agt ttg gga gaa gtg     2164
 Asp Pro Leu Pro Leu Ser Gln Gln Pro Gly Asp Ser Leu Gly Glu Val
 695                 700                 705                 710

 aat gac cca tat acc ttt gaa gat ggt gac ata aaa tac atc ttt aca     2212
 Asn Asp Pro Tyr Thr Phe Glu Asp Gly Asp Ile Lys Tyr Ile Phe Thr
                 715                 720                 725

 gcc aac aag aaa tgc aaa caa ggg acg gag aaa gat tcc ctg aaa aag     2260
 Ala Asn Lys Lys Cys Lys Gln Gly Thr Glu Lys Asp Ser Leu Lys Lys
             730                 735                 740

 aat aag tca gag gat gga ttt ggt acc aag gat gtc act aca cca ggt     2308
 Asn Lys Ser Glu Asp Gly Phe Gly Thr Lys Asp Val Thr Thr Pro Gly
         745                 750                 755

 cat tcc acg ccg gtg cct gat ggg aaa aat gcc atg tct att ttc agt     2356
 His Ser Thr Pro Val Pro Asp Gly Lys Asn Ala Met Ser Ile Phe Ser
     760                 765                 770

 tct gct act aaa aca gat gtc cgg cag gat aat gct gct ggc aga gct     2404
 Ser Ala Thr Lys Thr Asp Val Arg Gln Asp Asn Ala Ala Gly Arg Ala
 775                 780                 785                 790

 ggc tcc agt agc ctt aca cag gta aca gat ttg gca cct tcc ctg cat     2452
 Gly Ser Ser Ser Leu Thr Gln Val Thr Asp Leu Ala Pro Ser Leu His
                 795                 800                 805

 gac tta gac aac atc ttt gat aat tct gat gac gac gaa ctt ggg gct     2500
 Asp Leu Asp Asn Ile Phe Asp Asn Ser Asp Asp Asp Glu Leu Gly Ala
             810                 815                 820

 gta tca cct gct ctg cgc tca tca aaa atg cct gca gtt ggg aca gaa     2548
 Val Ser Pro Ala Leu Arg Ser Ser Lys Met Pro Ala Val Gly Thr Glu
         825                 830                 835

 gac cga cct ctt ggg aag gat gga aga gct gct gtt cct tat cca cca     2596
 Asp Arg Pro Leu Gly Lys Asp Gly Arg Ala Ala Val Pro Tyr Pro Pro
     840                 845                 850

 aca gtt gca gac ttg caa agg atg ttt ccc act cca cca tct ttg gaa     2644
 Thr Val Ala Asp Leu Gln Arg Met Phe Pro Thr Pro Pro Ser Leu Glu
 855                 860                 865                 870

 cag cat cct gca ttt tct cct gtg atg aat tat aaa gat ggg atc agc     2692
 Gln His Pro Ala Phe Ser Pro Val Met Asn Tyr Lys Asp Gly Ile Ser
                 875                 880                 885

 tca gag aca gtg aca gca tta ggc atg atg gag agc cct atg gtc agt     2740
 Ser Glu Thr Val Thr Ala Leu Gly Met Met Glu Ser Pro Met Val Ser
             890                 895                 900

 atg gtt tca aca caa ctc aca gaa ttc aaa atg gaa gtg gaa gat gga     2788
 Met Val Ser Thr Gln Leu Thr Glu Phe Lys Met Glu Val Glu Asp Gly
         905                 910                 915

 tta gga agt ccc aag ccc gag gaa att aag gac ttt tca tat gtg cac     2836
 Leu Gly Ser Pro Lys Pro Glu Glu Ile Lys Asp Phe Ser Tyr Val His
     920                 925                 930

 aaa gtt cca tcc ttt caa cct ttt gtg gga tcc tcc atg ttt gct cca     2884
 Lys Val Pro Ser Phe Gln Pro Phe Val Gly Ser Ser Met Phe Ala Pro
 935                 940                 945                 950

 ctg aag atg ttg ccg agc cat tgt ttg cta cct ctg aag ata cct gat     2932
 Leu Lys Met Leu Pro Ser His Cys Leu Leu Pro Leu Lys Ile Pro Asp
                 955                 960                 965

 gcc tgt ctg ttt cgg cct tca tgg gca att cct cct aaa att gaa caa     2980
 Ala Cys Leu Phe Arg Pro Ser Trp Ala Ile Pro Pro Lys Ile Glu Gln
             970                 975                 980

 ctg ccc atg ccc cct gca gcc act ttc att aga gat ggc tac aat aac     3028
 Leu Pro Met Pro Pro Ala Ala Thr Phe Ile Arg Asp Gly Tyr Asn Asn
         985                 990                 995

 gtg cct agt gtt ggg agc cta gca gat cca gac tat ctg aac aca cca     3076
 Val Pro Ser Val Gly Ser Leu Ala Asp Pro Asp Tyr Leu Asn Thr Pro
    1000                1005                1010

 cag atg aac aca ccc gtg acg ttg aac agc gct gcc cca gcc agc aat     3124
 Gln Met Asn Thr Pro Val Thr Leu Asn Ser Ala Ala Pro Ala Ser Asn
1015                1020                1025                1030

 agt ggg gca gga gtc cta cca tct cca gca acc cct cgc ttc tct gtc     3172
 Ser Gly Ala Gly Val Leu Pro Ser Pro Ala Thr Pro Arg Phe Ser Val
                1035                1040                1045

 ccc aca cca cga acc ccc agg acc cca aga act ccc aga ggt ggg ggc     3220
 Pro Thr Pro Arg Thr Pro Arg Thr Pro Arg Thr Pro Arg Gly Gly Gly
            1050                1055                1060

 act gcc agt ggt caa ggg tct gtt aag tat gat agc acc gat caa gga     3268
 Thr Ala Ser Gly Gln Gly Ser Val Lys Tyr Asp Ser Thr Asp Gln Gly
        1065                1070                1075

 tca cca gcc tcc acc ccc tct act aca cgg ccc ctc aac tct gtg gag     3316
 Ser Pro Ala Ser Thr Pro Ser Thr Thr Arg Pro Leu Asn Ser Val Glu
    1080                1085                1090

 ccc gcc acc atg cag cca att ccc gaa gcc cac agc ctc tat gtt acc     3364
 Pro Ala Thr Met Gln Pro Ile Pro Glu Ala His Ser Leu Tyr Val Thr
1095                1100                1105                1110

 ctg att ctc tcc gat tcc gtg atg aat atc ttt aaa gac aga aac ttt     3412
 Leu Ile Leu Ser Asp Ser Val Met Asn Ile Phe Lys Asp Arg Asn Phe
                1115                1120                1125

 gac agc tgt tgc atc tgt gcc tgc aac atg aac atc aaa ggg gcg gat     3460
 Asp Ser Cys Cys Ile Cys Ala Cys Asn Met Asn Ile Lys Gly Ala Asp
            1130                1135                1140

 gtc ggg ctt tac atc ccc gat tct tcc aat gag gac cag tac cgc tgt     3508
 Val Gly Leu Tyr Ile Pro Asp Ser Ser Asn Glu Asp Gln Tyr Arg Cys
        1145                1150                1155

 acc tgt ggg ttt agt gcg att atg aac cgc aaa ctt ggc tac aat tca     3556
 Thr Cys Gly Phe Ser Ala Ile Met Asn Arg Lys Leu Gly Tyr Asn Ser
    1160                1165                1170

 gga ctc ttc ctt gaa gat gag ttg gat att ttt ggg aag aat tct gat     3604
 Gly Leu Phe Leu Glu Asp Glu Leu Asp Ile Phe Gly Lys Asn Ser Asp
1175                1180                1185                1190

 att ggt cag gct gca gag agg cgc tta atg atg tgt cag tcc acc ttc     3652
 Ile Gly Gln Ala Ala Glu Arg Arg Leu Met Met Cys Gln Ser Thr Phe
                1195                1200                1205

 ctt cct cag gtg gaa gga acc aaa aaa ccc cag gag cca ccc ata agc     3700
 Leu Pro Gln Val Glu Gly Thr Lys Lys Pro Gln Glu Pro Pro Ile Ser
            1210                1215                1220

 ctt ctc ctc ctc ctc cag aat caa cac aca caa cct ttt gct tca ctg     3748
 Leu Leu Leu Leu Leu Gln Asn Gln His Thr Gln Pro Phe Ala Ser Leu
        1225                1230                1235

 aat ttc ctg gac tac att tcc tct aac aat cgc caa act ctt ccc tgt     3796
 Asn Phe Leu Asp Tyr Ile Ser Ser Asn Asn Arg Gln Thr Leu Pro Cys
    1240                1245                1250

 gta agc tgg agt tat gac cgg gtg caa gca gat aat aat gat tac tgg     3844
 Val Ser Trp Ser Tyr Asp Arg Val Gln Ala Asp Asn Asn Asp Tyr Trp
1255                1260                1265                1270

 acg gaa tgc ttt aat gcg ttg gag cag ggg cgg cag tat gtg gat aac     3892
 Thr Glu Cys Phe Asn Ala Leu Glu Gln Gly Arg Gln Tyr Val Asp Asn
                1275                1280                1285

 ccc act ggt gga aaa gtg gac gaa gct ctg gtg aga agt gcc act gtg     3940
 Pro Thr Gly Gly Lys Val Asp Glu Ala Leu Val Arg Ser Ala Thr Val
            1290                1295                1300

 cac tct tgg cct cac agc aat gtg ctg gac atc agc atg ctc tcc tcc     3988
 His Ser Trp Pro His Ser Asn Val Leu Asp Ile Ser Met Leu Ser Ser
        1305                1310                1315

 cag gat gtg gtt cgt atg ctg ttg tcc ctg cag ccc ttt ctc caa gat     4036
 Gln Asp Val Val Arg Met Leu Leu Ser Leu Gln Pro Phe Leu Gln Asp
    1320                1325                1330

 gcc atc caa aag aag cgc acg ggc agg acc tgg gag aac atc cag cat     4084
 Ala Ile Gln Lys Lys Arg Thr Gly Arg Thr Trp Glu Asn Ile Gln His
1335                1340                1345                1350

 gtg cag gga cca ctc act tgg cag cag ttc cat aaa atg gca gga cgg     4132
 Val Gln Gly Pro Leu Thr Trp Gln Gln Phe His Lys Met Ala Gly Arg
                1355                1360                1365

 gga acc tac ggt tcg gaa gaa tct cct gag ccg ttg ccc atc ccc act     4180
 Gly Thr Tyr Gly Ser Glu Glu Ser Pro Glu Pro Leu Pro Ile Pro Thr
            1370                1375                1380

 ctg ctg gta ggc tat gac aag gat ttc ctc acc atc tcg cca ttc tcc     4228
 Leu Leu Val Gly Tyr Asp Lys Asp Phe Leu Thr Ile Ser Pro Phe Ser
        1385                1390                1395

 ttg ccg ttt tgg gag agg ctc ttg ttg gac cca tat ggg ggc cac cgt     4276
 Leu Pro Phe Trp Glu Arg Leu Leu Leu Asp Pro Tyr Gly Gly His Arg
    1400                1405                1410

 gat gtt gcc tat att gtg gtg tgt cca gaa aat gag gcc ttg ctc gaa     4324
 Asp Val Ala Tyr Ile Val Val Cys Pro Glu Asn Glu Ala Leu Leu Glu
1415                1420                1425                1430

 gga gcc aaa act ttc ttc agg gac ttg agt gct gta tac gag atg tgt     4372
 Gly Ala Lys Thr Phe Phe Arg Asp Leu Ser Ala Val Tyr Glu Met Cys
                1435                1440                1445

 agg ctt ggg cag cac aag ccc atc tgc aaa gtg cta cgt gac ggg atc     4420
 Arg Leu Gly Gln His Lys Pro Ile Cys Lys Val Leu Arg Asp Gly Ile
            1450                1455                1460

 atg cgc gtg gga aaa act gtg gca cag aag ctg aca gat gag ctt gtg     4468
 Met Arg Val Gly Lys Thr Val Ala Gln Lys Leu Thr Asp Glu Leu Val
        1465                1470                1475

 agt gag tgg ttt aac cag cct tgg agc ggc gag gag aat gac aat cat     4516
 Ser Glu Trp Phe Asn Gln Pro Trp Ser Gly Glu Glu Asn Asp Asn His
    1480                1485                1490

 tcc aga ctc aaa ctt tat gcg caa gtt tgc cgc cat cac cta gca cct     4564
 Ser Arg Leu Lys Leu Tyr Ala Gln Val Cys Arg His His Leu Ala Pro
1495                1500                1505                1510

 tat tta gcc act ctg cag ctt gat agc agc cta ttg ata cca cct aaa     4612
 Tyr Leu Ala Thr Leu Gln Leu Asp Ser Ser Leu Leu Ile Pro Pro Lys
                1515                1520                1525

 tac cag acc cca cca gca gca gca cag gga caa gct acg cca ggg aat     4660
 Tyr Gln Thr Pro Pro Ala Ala Ala Gln Gly Gln Ala Thr Pro Gly Asn
            1530                1535                1540

 gct ggg ccc tta gct cca aat gga tca gca gct ccc cca gct ggc agt     4708
 Ala Gly Pro Leu Ala Pro Asn Gly Ser Ala Ala Pro Pro Ala Gly Ser
        1545                1550                1555

 gca ttt aat ccc acc tcg aat agt agt tct aca aat cct gca gca agt     4756
 Ala Phe Asn Pro Thr Ser Asn Ser Ser Ser Thr Asn Pro Ala Ala Ser
    1560                1565                1570

 agt tct gca tct ggt tcc tct gtg cca ccg gtc tca tcg tct gcc tct     4804
 Ser Ser Ala Ser Gly Ser Ser Val Pro Pro Val Ser Ser Ser Ala Ser
1575                1580                1585                1590

 gct cct ggt att agc cag ata agc act acc tct tct tca gga ttc agt     4852
 Ala Pro Gly Ile Ser Gln Ile Ser Thr Thr Ser Ser Ser Gly Phe Ser
                1595                1600                1605

 ggt agt gtt gga ggg cag aac ccc agc act ggg ggc att tct gcg gat     4900
 Gly Ser Val Gly Gly Gln Asn Pro Ser Thr Gly Gly Ile Ser Ala Asp
            1610                1615                1620

 aga acg caa ggg aac ata ggc tgt ggt gga gac act gac cct ggg cag     4948
 Arg Thr Gln Gly Asn Ile Gly Cys Gly Gly Asp Thr Asp Pro Gly Gln
        1625                1630                1635

 agc tct tct cag ccc tca cag gat gga caa gag agt gtt aca gaa agg     4996
 Ser Ser Ser Gln Pro Ser Gln Asp Gly Gln Glu Ser Val Thr Glu Arg
    1640                1645                1650

 gag aga ata gga att ccc acg gag cct gac tct gca gac agc cat gcc     5044
 Glu Arg Ile Gly Ile Pro Thr Glu Pro Asp Ser Ala Asp Ser His Ala
1655                1660                1665                1670

 cac cct cca gct gtt gtc att tac atg gtg gac ccg ttc acg tat gct     5092
 His Pro Pro Ala Val Val Ile Tyr Met Val Asp Pro Phe Thr Tyr Ala
                1675                1680                1685

 gca gag gag gac tcc act tct ggg aac ttt tgg ctg ttg agc ttg atg     5140
 Ala Glu Glu Asp Ser Thr Ser Gly Asn Phe Trp Leu Leu Ser Leu Met
            1690                1695                1700

 cgc tgc tac aca gaa atg ctg gat aat tta cct gag cat atg aga aat     5188
 Arg Cys Tyr Thr Glu Met Leu Asp Asn Leu Pro Glu His Met Arg Asn
        1705                1710                1715

 tct ttc att ctc cag att gtg cct tgc cag tac atg ctg cag aca atg     5236
 Ser Phe Ile Leu Gln Ile Val Pro Cys Gln Tyr Met Leu Gln Thr Met
    1720                1725                1730

 aag gat gag caa gtt ttc tac att caa tac ttg aag tcc atg gca ttt     5284
 Lys Asp Glu Gln Val Phe Tyr Ile Gln Tyr Leu Lys Ser Met Ala Phe
1735                1740                1745                1750

 tca gtg tac tgc cag tgc agg cga cca ctg cct aca cag atc cac att     5332
 Ser Val Tyr Cys Gln Cys Arg Arg Pro Leu Pro Thr Gln Ile His Ile
                1755                1760                1765

 aaa tcc ctc acg gga ttt ggg cct gca gcc agc att gag atg acc ctc     5380
 Lys Ser Leu Thr Gly Phe Gly Pro Ala Ala Ser Ile Glu Met Thr Leu
            1770                1775                1780

 aag aac cct gag cgg ccc agc cca atc cag ctt tac tcc cct ccc ttt     5428
 Lys Asn Pro Glu Arg Pro Ser Pro Ile Gln Leu Tyr Ser Pro Pro Phe
        1785                1790                1795

 ata ttg gcc cca atc aaa gac aag cag aca gag ctg gga gag acg ttt     5476
 Ile Leu Ala Pro Ile Lys Asp Lys Gln Thr Glu Leu Gly Glu Thr Phe
    1800                1805                1810

 ggt gag gcg agc cag aaa tac aat gtg ctc ttc gtg ggc tat tgt ctg     5524
 Gly Glu Ala Ser Gln Lys Tyr Asn Val Leu Phe Val Gly Tyr Cys Leu
1815                1820                1825                1830

 tct cac gac cag cgc tgg ctt ttg gct tcc tgc act gac ctc cat ggg     5572
 Ser His Asp Gln Arg Trp Leu Leu Ala Ser Cys Thr Asp Leu His Gly
                1835                1840                1845

 gaa tta tta gag acc tgc gtt gta aat att gct tta cca aac agg tca     5620
 Glu Leu Leu Glu Thr Cys Val Val Asn Ile Ala Leu Pro Asn Arg Ser
            1850                1855                1860

 cgg agg agt aaa gta tct gca cgt aaa att gga cta cag aag tta tgg     5668
 Arg Arg Ser Lys Val Ser Ala Arg Lys Ile Gly Leu Gln Lys Leu Trp
        1865                1870                1875

 gag tgg tgc ata ggg att gtc caa atg aca tct cta ccc tgg aga gtt     5716
 Glu Trp Cys Ile Gly Ile Val Gln Met Thr Ser Leu Pro Trp Arg Val
    1880                1885                1890

 gta atc ggg cga ctt ggg cgt ctt ggc cat ggg gag ctt aaa gat tgg     5764
 Val Ile Gly Arg Leu Gly Arg Leu Gly His Gly Glu Leu Lys Asp Trp
1895                1900                1905                1910

 agt atc ctc ctt gga gaa tgt tca cta cag aca atc agc aaa aag ctc     5812
 Ser Ile Leu Leu Gly Glu Cys Ser Leu Gln Thr Ile Ser Lys Lys Leu
                1915                1920                1925

 aag gat gtg tgc cgg atg tgt gga atc tct gcc gca gac tct cct tct     5860
 Lys Asp Val Cys Arg Met Cys Gly Ile Ser Ala Ala Asp Ser Pro Ser
            1930                1935                1940

 atc ctt agt gcc tgc ctg gtt gcc atg gag ccc cag ggg tcc ttt gta     5908
 Ile Leu Ser Ala Cys Leu Val Ala Met Glu Pro Gln Gly Ser Phe Val
        1945                1950                1955

 gtg atg cca gat gct gtc aca atg ggc tct gtt ttt ggc cga agt act     5956
 Val Met Pro Asp Ala Val Thr Met Gly Ser Val Phe Gly Arg Ser Thr
    1960                1965                1970

 gca ctg aac atg cag tca tct cag ctc aac acc cct caa gat gct tct     6004
 Ala Leu Asn Met Gln Ser Ser Gln Leu Asn Thr Pro Gln Asp Ala Ser
1975                1980                1985                1990

 tgt aca cac atc ttg gtg ttc cca aca tca tca acc atc cag gtg gct     6052
 Cys Thr His Ile Leu Val Phe Pro Thr Ser Ser Thr Ile Gln Val Ala
                1995                2000                2005

 cca gcc aac tac ccc aat gaa gat ggg ttt agc ccc aac aat gat gat     6100
 Pro Ala Asn Tyr Pro Asn Glu Asp Gly Phe Ser Pro Asn Asn Asp Asp
            2010                2015                2020

 atg ttt gtt gac ctt cca ttc cca gat gat atg gac aat gat att ggc     6148
 Met Phe Val Asp Leu Pro Phe Pro Asp Asp Met Asp Asn Asp Ile Gly
        2025                2030                2035

 ata tta atg act ggg aac ctc cat tcc tct ccc aac tct tcc cca gta     6196
 Ile Leu Met Thr Gly Asn Leu His Ser Ser Pro Asn Ser Ser Pro Val
    2040                2045                2050

 ccc tcc cca ggc tct cct tct gga att ggt gtg ggc tct cac ttc cag     6244
 Pro Ser Pro Gly Ser Pro Ser Gly Ile Gly Val Gly Ser His Phe Gln
2055                2060                2065                2070

 cat agt cgg agc cag ggt gag cgt ctt ctt tct aga gaa gca cca gag     6292
 His Ser Arg Ser Gln Gly Glu Arg Leu Leu Ser Arg Glu Ala Pro Glu
                2075                2080                2085

 gag cta aag cag cag ccc ctg gcc ctt ggg tat ttt gta tca act gcc     6340
 Glu Leu Lys Gln Gln Pro Leu Ala Leu Gly Tyr Phe Val Ser Thr Ala
            2090                2095                2100

 aaa gct gag aat ctt ccc cag tgg ttt tgg tca tcg tgt ccc cag gct     6388
 Lys Ala Glu Asn Leu Pro Gln Trp Phe Trp Ser Ser Cys Pro Gln Ala
        2105                2110                2115

 caa aac cag tgc cct ctc ttc tta aag gct tcg ctg cat cac cac att     6436
 Gln Asn Gln Cys Pro Leu Phe Leu Lys Ala Ser Leu His His His Ile
    2120                2125                2130

 tca gta gca cag aca gac gaa ctt ctg cct gcc agg aat tct cag cgg     6484
 Ser Val Ala Gln Thr Asp Glu Leu Leu Pro Ala Arg Asn Ser Gln Arg
2135                2140                2145                2150

 gtt cca cac cct ctt gac tcc aaa acc acg tcg gat gtt tta agg ttt     6532
 Val Pro His Pro Leu Asp Ser Lys Thr Thr Ser Asp Val Leu Arg Phe
                2155                2160                2165

 gtt ttg gag cag tac aac gct ctg tcc tgg ctc acg tgc aat ccg gcc     6580
 Val Leu Glu Gln Tyr Asn Ala Leu Ser Trp Leu Thr Cys Asn Pro Ala
            2170                2175                2180

 acc cag gac cgt act tcc tgc ctt ccc gtc cac ttt gtg gtg ctc act     6628
 Thr Gln Asp Arg Thr Ser Cys Leu Pro Val His Phe Val Val Leu Thr
        2185                2190                2195

 cag ttg tac aat gcc atc atg aat ata ctt taa ttggaaaa gcacttgttc     6679
 Gln Leu Tyr Asn Ala Ile Met Asn Ile Leu 
    2200                2205

 tctctggctc agttccttct ccctgcaacc tcagtccaag gaacctgcta cactctgcaa   6739

 ataacccaca tccttttctt cagaccactc tccacagtcc tgcactgtga ttccttctca   6799

 gcaggcacat gtcaattctg cagtgttcat taccagagtg actccttgac acttctctca   6859

 tggacctgga aacttccata agtggtgact ttcagccagt gcggtggtgt gtgtagcccc   6919

 aaccactggt ccccaggaag tggtggtggt tgatggcttt tcagcgggaa acagaagaga   6979

 cagtgtcctt ttgcacaaga gtctgtgttt tcagcctctg tatacaattg agggcagtct   7039

 agccctttgg atgaaatcct cttagttact ggtgtatggc ctgtgggtta cctgaactcc   7099

 ataatcgggg actttttaaa aataagaacc agctcaagta catggtttca tactggggtt   7159

 tctgtctccc tagtgttccc atccagatta gcatgagtgc tttggttgac ttcaaacctg   7219

 tgtgtcaatg cagaaggtct ggagacagct tcattttgtt tatttatttt aatttgtttt   7279

 gtcatatggt ttttgtgact ttattttttt aattcacaag gaccaggtac agtagctgaa   7339

 acccaattca gatccaccat aggattcttt gactacatac ctctgtccta gaagccggaa   7399

 aaggagtaaa aacacattgg ggagatcatg cctaaaagta atatattcaa aaccacccag   7459

 cagtaggttt tgttaacaac aaactggatt ttaaaagttc tgccatgtta agtggccagc   7519

 atttcatgaa ggataacatt tttatacaga aggcagtcaa gctcaactca gagccatgga   7579

 ggcaagtacc ttaattagtt ttatatagtc acaacggaaa tatattttct agtgaattct   7639

 tattggaagc caggtctctc ctctcattag atcaaaaggg acttatgtac atacaacaat   7699

 tgaaagtgtt tgctcatgaa atcagttata aatatggtga attttttctg gaccatagga   7759

 atattatttc aaagaaatat tacaacttaa ccattaaatt agtacttgaa gttgagcctt   7819

 tgtggtggga ctttttaaaa aaatgccttt ttaaagcatt aatggctaat tgaagtattt   7879

 tatgactcct cattcctggc ccagagggtt gtctttgaaa ccctgtttct aacccttgtg   7939

 ttgtgtgttt ctgtctgagg acagtgggtg tgtactggcc tcccgggagc cactgtgacc   7999

 aggcctttga gctcttgtca tctgtggaga gaatcatgca aattttaaaa gttcttccaa   8059

 gagacttcca tgtcctggtt attaacaaaa aaggaaaaat gtaataattg atatgatttt   8119

 gtaaaagtat ttttcttgaa ataatctaaa gtttaaaaca ttatattaaa aaaaaaagtt   8179

 gtgtggtggg aatgtgaaag cagagaaata acttgtaaat ggataatttt gttctctgta   8239

 ccaccagttg aagggggggt tgactttcgc aatgtatagg ataaaaaatc tgatatatca   8299

 aaccatttgt atctaatgtg tacagtgtaa aattgacttt aaaaatattg cagtgctatt   8359

 ttttcttaat cagaaaggaa aattctcaag gccttttgaa gagcataaga agatgaagat   8419

 tgtaaacttg tataaaatta tcttggtgag aagacaaatt gtaaagtaga tatttgtaat   8479

 cttttaccac tttggggttg cttttttccc ggaattcatc agaactttga attttttttt   8539

 taaatgggct gtttttaatg caggggcttt tcttccctag aaacccaatt ctaagcagaa   8599

 aaagaaaaaa aacacaaaaa ataaaaaacc cctacaaaaa aactttaaaa aaaatggcag   8659

 caaagggtag ttttcatctg gtgtctttta tttaagtttt ttaagttaag aaaagctggt   8719

 gacatattta tacgtttttg tgcaaaaata aatgaatggc aatagatttt aaaaaatctt   8779

 attatgtact tctgtgtgaa aaagtctgta taatatttcc cttaaatatg cattatttta   8839

 cttgtgagtt ttttactgaa ttaatctgaa atgtacaagc cctggatttg ctacagagtg   8899

 agaagttatt ttattttttt ttatttttaa ttttggaaat tctgcagaaa tcagaactct   8959

 taccatggtt tgaacaaaaa aaggggaaat ggggagggga aaagggtggg attgtccagc   9019

 atgcttgtat gtatatttca gaaccttttt taaatgtaaa agctgtacat ttctgggaag   9079

 ttctgaattt cttttgtttc cttttttcct tcaagcattt tgcagtgagc ttcttttata   9139

 tatagcaaac aatttgaaag aatacaaaaa tatgtgaagt tcatttaaaa aaataactac   9199

 agtatagcgc tggtacagta cactaaaaga ctttgataaa aagaaacaat aataaaaggc   9259

 ctccatttta aatgtcattc atatatacct tgtggatgag agctatatac ttttacacac   9319

 ttttttagag gaataaatta ttgaattact g                                  9350




      <210> 547
      <211> 2312
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (55)..(2271)

      <400> 547
 ggccggcggc cgctgaccgt ggtgctgcag ggcccggcgg gcatcggcaa gacc  atg      57
                                                              Met
                                                                1

 gcg gcc aaa aag atc ctg tac gac tgg gcg gcg ggc aag ctg tac cag      105
 Ala Ala Lys Lys Ile Leu Tyr Asp Trp Ala Ala Gly Lys Leu Tyr Gln
               5                  10                  15

 ggc cag gtg gac ttc gcc ttc ttc atg ccc tgc ggc gag ctg ctg gag      153
 Gly Gln Val Asp Phe Ala Phe Phe Met Pro Cys Gly Glu Leu Leu Glu
          20                  25                  30

 agg ccg ggc acg cgc agc ctg gct gac ctg atc ctg gac cag tgc ccc      201
 Arg Pro Gly Thr Arg Ser Leu Ala Asp Leu Ile Leu Asp Gln Cys Pro
      35                  40                  45

 gac cgc ggc gcg ccg gtg ccg cag atg ctg gcc cag ccg cag cgg ctg      249
 Asp Arg Gly Ala Pro Val Pro Gln Met Leu Ala Gln Pro Gln Arg Leu
  50                  55                  60                  65

 ctc ttc atc ctg gac ggc gcg gac gag ctg ccg gcg ctg ggg ggc ccc      297
 Leu Phe Ile Leu Asp Gly Ala Asp Glu Leu Pro Ala Leu Gly Gly Pro
                  70                  75                  80

 gag gcc gcg ccc tgc aca gac ccc ttc gag gcg gcg agc ggc gcg cgg      345
 Glu Ala Ala Pro Cys Thr Asp Pro Phe Glu Ala Ala Ser Gly Ala Arg
              85                  90                  95

 gtg cta ggc ggg ctg ctg agc aag gcg ctg ctg ccc acg gcc ctc ctg      393
 Val Leu Gly Gly Leu Leu Ser Lys Ala Leu Leu Pro Thr Ala Leu Leu
         100                 105                 110

 ctg gtg acc acg cgc gcc gcc gcc ccc ggg agg ctg cag ggc cgc ctg      441
 Leu Val Thr Thr Arg Ala Ala Ala Pro Gly Arg Leu Gln Gly Arg Leu
     115                 120                 125

 tgt tcc ccg cag tgc gcc gag gtg cgc ggc ttc tcc gac aag gac aag      489
 Cys Ser Pro Gln Cys Ala Glu Val Arg Gly Phe Ser Asp Lys Asp Lys
 130                 135                 140                 145

 aag aag tat ttc tac aag ttc ttc cgg gat gag agg agg gcc gag cgc      537
 Lys Lys Tyr Phe Tyr Lys Phe Phe Arg Asp Glu Arg Arg Ala Glu Arg
                 150                 155                 160

 gcc tac cgc ttc gtg aag gag aac gag acg ctg ttc gcg ctg tgc ttc      585
 Ala Tyr Arg Phe Val Lys Glu Asn Glu Thr Leu Phe Ala Leu Cys Phe
             165                 170                 175

 gtg ccc ttc gtg tgc tgg atc gtg tgc acc gtg ctg cgc cag cag ctg      633
 Val Pro Phe Val Cys Trp Ile Val Cys Thr Val Leu Arg Gln Gln Leu
         180                 185                 190

 gag ctc ggt cgg gac ctg tcg cgc acg tcc aag acc acc acg tca gtg      681
 Glu Leu Gly Arg Asp Leu Ser Arg Thr Ser Lys Thr Thr Thr Ser Val
     195                 200                 205

 tac ctg ctt ttc atc acc agc gtt ctg agc tcg gct ccg gta gcc gac      729
 Tyr Leu Leu Phe Ile Thr Ser Val Leu Ser Ser Ala Pro Val Ala Asp
 210                 215                 220                 225

 ggg ccc cgg ttg cag ggc gac ctg cgc aat ctg tgc cgc ctg gcc cgc      777
 Gly Pro Arg Leu Gln Gly Asp Leu Arg Asn Leu Cys Arg Leu Ala Arg
                 230                 235                 240

 gag ggc gtc ctc gga cgc agg gcg cag ttt gcc gag aag gaa ctg gag      825
 Glu Gly Val Leu Gly Arg Arg Ala Gln Phe Ala Glu Lys Glu Leu Glu
             245                 250                 255

 caa ctg gag ctt cgt ggc tcc aaa gtg cag acg ctg ttt ctc agc aaa      873
 Gln Leu Glu Leu Arg Gly Ser Lys Val Gln Thr Leu Phe Leu Ser Lys
         260                 265                 270

 aag gag ctg ccg ggc gtg ctg gag aca gag gtc acc tac cag ttc atc      921
 Lys Glu Leu Pro Gly Val Leu Glu Thr Glu Val Thr Tyr Gln Phe Ile
     275                 280                 285

 gac cag agc ttc cag gag ttc ctc gcg gca ctg tcc tac ctg ctg gag      969
 Asp Gln Ser Phe Gln Glu Phe Leu Ala Ala Leu Ser Tyr Leu Leu Glu
 290                 295                 300                 305

 gac ggc ggg gtg ccc agg acc gcg gct ggc ggc gtt ggg aca ctc ctg     1017
 Asp Gly Gly Val Pro Arg Thr Ala Ala Gly Gly Val Gly Thr Leu Leu
                 310                 315                 320

 cgt ggg gac gcc cag ccg cac agc cac ttg gtg ctc acc acg cgc ttc     1065
 Arg Gly Asp Ala Gln Pro His Ser His Leu Val Leu Thr Thr Arg Phe
             325                 330                 335

 ctc ttc gga ctg ctg agc gcg gaa cgg atg cgc gac atc gag cgc cac     1113
 Leu Phe Gly Leu Leu Ser Ala Glu Arg Met Arg Asp Ile Glu Arg His
         340                 345                 350

 ttc ggc tgc atg gtt tca gag cgt gtg aag cag gag gcc ctg cgg tgg     1161
 Phe Gly Cys Met Val Ser Glu Arg Val Lys Gln Glu Ala Leu Arg Trp
     355                 360                 365

 gtg cag gga cag gga cag ggc tgc ccc gga gtg gca cca gag gtg acc     1209
 Val Gln Gly Gln Gly Gln Gly Cys Pro Gly Val Ala Pro Glu Val Thr
 370                 375                 380                 385

 gag ggg gcc aaa ggg ctc gag gac acc gaa gag cca gag gag gag gag     1257
 Glu Gly Ala Lys Gly Leu Glu Asp Thr Glu Glu Pro Glu Glu Glu Glu
                 390                 395                 400

 gag gga gag gag ccc aac tac cca ctg gag ttg ctg tac tgc ctg tac     1305
 Glu Gly Glu Glu Pro Asn Tyr Pro Leu Glu Leu Leu Tyr Cys Leu Tyr
             405                 410                 415

 gag acg cag gag gac gcg ttt gtg cgc caa gcc ctg tgc cgg ttc ccg     1353
 Glu Thr Gln Glu Asp Ala Phe Val Arg Gln Ala Leu Cys Arg Phe Pro
         420                 425                 430

 gag ctg gcg ctg cag cga gtg cgc ttc tgc cgc atg gac gtg gct gtt     1401
 Glu Leu Ala Leu Gln Arg Val Arg Phe Cys Arg Met Asp Val Ala Val
     435                 440                 445

 ctg agc tac tgc gtg agg tgc tgc cct gct gga cag gca ctg cgg ctg     1449
 Leu Ser Tyr Cys Val Arg Cys Cys Pro Ala Gly Gln Ala Leu Arg Leu
 450                 455                 460                 465

 atc agc tgc aga ttg gtt gct gcg cag gag aag aag aag aag agc ctg     1497
 Ile Ser Cys Arg Leu Val Ala Ala Gln Glu Lys Lys Lys Lys Ser Leu
                 470                 475                 480

 ggg aag cgg ctc cag gcc agc ctg ggt ggc ggc agc tgg ctg ggg acc     1545
 Gly Lys Arg Leu Gln Ala Ser Leu Gly Gly Gly Ser Trp Leu Gly Thr
             485                 490                 495

 caa ctg gct cca gaa gta ccc ttt cga cca ccc tgc tgt gac atc tgc     1593
 Gln Leu Ala Pro Glu Val Pro Phe Arg Pro Pro Cys Cys Asp Ile Cys
         500                 505                 510

 ccc aca cct cca cca gac cct cgg ctc ctc cag ggc aag gct ttt gcc     1641
 Pro Thr Pro Pro Pro Asp Pro Arg Leu Leu Gln Gly Lys Ala Phe Ala
     515                 520                 525

 aga gtt cct ttg aat ata gct cca att cag ccc ctg ccc agg ggc ttg     1689
 Arg Val Pro Leu Asn Ile Ala Pro Ile Gln Pro Leu Pro Arg Gly Leu
 530                 535                 540                 545

 gca tct gtt gag agg atg aat gtc acg gtg ttg gca ggg gct ggg cct     1737
 Ala Ser Val Glu Arg Met Asn Val Thr Val Leu Ala Gly Ala Gly Pro
                 550                 555                 560

 ggg gac cca aag acc cat gca atg act gac cca ctg tgc cat ctg agc     1785
 Gly Asp Pro Lys Thr His Ala Met Thr Asp Pro Leu Cys His Leu Ser
             565                 570                 575

 agc ctc acg ctg tcc cac tgc aaa ctc cct gac gcg gtc tgc cga gac     1833
 Ser Leu Thr Leu Ser His Cys Lys Leu Pro Asp Ala Val Cys Arg Asp
         580                 585                 590

 ctt tct gag gcc ctg agg gca gcc ccc gca ctg acg gag ctg ggc ctc     1881
 Leu Ser Glu Ala Leu Arg Ala Ala Pro Ala Leu Thr Glu Leu Gly Leu
     595                 600                 605

 ctc cac aac agg ctc agt gag gcg gga ctg cgt atg ctg agt gag ggc     1929
 Leu His Asn Arg Leu Ser Glu Ala Gly Leu Arg Met Leu Ser Glu Gly
 610                 615                 620                 625

 cta gcc tgg ccg cag tgc agg gtg cag acg gtc agg gta cag ctg cct     1977
 Leu Ala Trp Pro Gln Cys Arg Val Gln Thr Val Arg Val Gln Leu Pro
                 630                 635                 640

 gac ccc cag cga ggg ctc cag tac ctg gtg ggt atg ctt cgg cag agc     2025
 Asp Pro Gln Arg Gly Leu Gln Tyr Leu Val Gly Met Leu Arg Gln Ser
             645                 650                 655

 ccc gcc ctg acc acc ctg gat ctc agt ggc tgc caa ctg ccc gcc ccc     2073
 Pro Ala Leu Thr Thr Leu Asp Leu Ser Gly Cys Gln Leu Pro Ala Pro
         660                 665                 670

 atg gtg acc tac ctg tgt gca gtc ctg cag cac cag gga tgc ggc ctg     2121
 Met Val Thr Tyr Leu Cys Ala Val Leu Gln His Gln Gly Cys Gly Leu
     675                 680                 685

 cag acc ctc agt ctg gcc tct gtg gag ctg agc gag cag tca cta cag     2169
 Gln Thr Leu Ser Leu Ala Ser Val Glu Leu Ser Glu Gln Ser Leu Gln
 690                 695                 700                 705

 gag ctt cag gct gtg aag aga gca aag ccg gat ctg gtc atc gca cac     2217
 Glu Leu Gln Ala Val Lys Arg Ala Lys Pro Asp Leu Val Ile Ala His
                 710                 715                 720

 cca gcg ctg gac ggc cac cca caa cct ccc aag gaa ctc atc tcg acc     2265
 Pro Ala Leu Asp Gly His Pro Gln Pro Pro Lys Glu Leu Ile Ser Thr
             725                 730                 735

 ttc tga ggctctggtg gccagagcag ggtggaagac cctagtcaaa g               2312
 Phe 






      <210> 548
      <211> 2045
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (100)..(1953)

      <400> 548
 cgcgcttagg gatccggccg tggccgagcg cgcggccgta agaccgcggg tgactagcat     60

 gcagataccc atgctctgac tttctgcccc tccactgac   atg gcc cac cgg ggt     114
                                              Met Ala His Arg Gly
                                                1               5

 ggg gag agg gac ttc cag act tca gct cga cgc atg ggc acc tcg ctg      162
 Gly Glu Arg Asp Phe Gln Thr Ser Ala Arg Arg Met Gly Thr Ser Leu
                  10                  15                  20

 ctc ttc cag ctt tca gtg cat gaa cgg gag ctg gac ctg gtt ttt ctg      210
 Leu Phe Gln Leu Ser Val His Glu Arg Glu Leu Asp Leu Val Phe Leu
              25                  30                  35

 gat cat agc tat gcc aag cct tgg agt gcc cac cca gat gcc agt agt      258
 Asp His Ser Tyr Ala Lys Pro Trp Ser Ala His Pro Asp Ala Ser Ser
          40                  45                  50

 gcc cgc ccc acc cgc atg ctc ttt gtc act ccc cgg cgg cag cac gaa      306
 Ala Arg Pro Thr Arg Met Leu Phe Val Thr Pro Arg Arg Gln His Glu
      55                  60                  65

 agt acc att gaa tca gac gtc cca ata gat gtg gag acg gtc aca tca      354
 Ser Thr Ile Glu Ser Asp Val Pro Ile Asp Val Glu Thr Val Thr Ser
  70                  75                  80                  85

 acg cct atg cca ctc tat gac aat cag aag gca cgc agc gtg atg aat      402
 Thr Pro Met Pro Leu Tyr Asp Asn Gln Lys Ala Arg Ser Val Met Asn
                  90                  95                 100

 gag tgt gaa cgg cat gtc atc ttt gcc agg act gat gca gat gcc cct      450
 Glu Cys Glu Arg His Val Ile Phe Ala Arg Thr Asp Ala Asp Ala Pro
             105                 110                 115

 cct cca cca gag gac tgg gag gag cat gtc aac agg act ggc tgg aca      498
 Pro Pro Pro Glu Asp Trp Glu Glu His Val Asn Arg Thr Gly Trp Thr
         120                 125                 130

 atg gcc cag aac aag cta ttc aac aag atc ctc aaa gcc ctg cag tct      546
 Met Ala Gln Asn Lys Leu Phe Asn Lys Ile Leu Lys Ala Leu Gln Ser
     135                 140                 145

 gac cgg ctt gcc cgc ttg gcc aac gaa ggg gct tgt aat gag cca gtg      594
 Asp Arg Leu Ala Arg Leu Ala Asn Glu Gly Ala Cys Asn Glu Pro Val
 150                 155                 160                 165

 ctg cgc cgt gtt gct gtg gac aag tgt gca agg aga gtg cgg cag gct      642
 Leu Arg Arg Val Ala Val Asp Lys Cys Ala Arg Arg Val Arg Gln Ala
                 170                 175                 180

 ctg gca agt gtg agc tgg gat acc aag ctg atc cag tgg ctg cac acc      690
 Leu Ala Ser Val Ser Trp Asp Thr Lys Leu Ile Gln Trp Leu His Thr
             185                 190                 195

 acc ctt gtg gag acc ttg agt ctg ccc atg ctg gca gcc tac ctg gat      738
 Thr Leu Val Glu Thr Leu Ser Leu Pro Met Leu Ala Ala Tyr Leu Asp
         200                 205                 210

 gct ttg cag acg ctg aag ggg aag atc cca acc ttg att gac cgg atg      786
 Ala Leu Gln Thr Leu Lys Gly Lys Ile Pro Thr Leu Ile Asp Arg Met
     215                 220                 225

 ctt gtg tca tcc aac aca aag act ggg gct gca gga gct gag gcc ttg      834
 Leu Val Ser Ser Asn Thr Lys Thr Gly Ala Ala Gly Ala Glu Ala Leu
 230                 235                 240                 245

 tct ctc cta ctg aag agg ccc tgg gac cct gct gtg ggt gtg ctt tct      882
 Ser Leu Leu Leu Lys Arg Pro Trp Asp Pro Ala Val Gly Val Leu Ser
                 250                 255                 260

 cat aac aaa cca agc aaa ctc cct ggc tct ccg ctg att ctc atc gcc      930
 His Asn Lys Pro Ser Lys Leu Pro Gly Ser Pro Leu Ile Leu Ile Ala
             265                 270                 275

 tcc tct ggt ccc tcc agc tct gtg ttt ccc act tca cgc cgc cac cgc      978
 Ser Ser Gly Pro Ser Ser Ser Val Phe Pro Thr Ser Arg Arg His Arg
         280                 285                 290

 ttc tgg caa tct cag ctg tct tgc ttg ggc aag gtc atc cct gta gcc     1026
 Phe Trp Gln Ser Gln Leu Ser Cys Leu Gly Lys Val Ile Pro Val Ala
     295                 300                 305

 acc cat ctg ctg aac aat ggc agt ggg gta gga gtt cta cag tgt ctc     1074
 Thr His Leu Leu Asn Asn Gly Ser Gly Val Gly Val Leu Gln Cys Leu
 310                 315                 320                 325

 gag cat atg att ggg gca gtg aga agc aaa gtg ctg gag att cac agc     1122
 Glu His Met Ile Gly Ala Val Arg Ser Lys Val Leu Glu Ile His Ser
                 330                 335                 340

 cat ttc cca cac aaa ccc att atc ttg att ggc tgg aac aca gga gct     1170
 His Phe Pro His Lys Pro Ile Ile Leu Ile Gly Trp Asn Thr Gly Ala
             345                 350                 355

 ttg gtg gcc tgt cat gtg tca gta atg gag tat gtc act gca gtt gtc     1218
 Leu Val Ala Cys His Val Ser Val Met Glu Tyr Val Thr Ala Val Val
         360                 365                 370

 tgc ctt ggg ttt cct ctg ctt act gtg gat ggc ccc aga ggg gat gta     1266
 Cys Leu Gly Phe Pro Leu Leu Thr Val Asp Gly Pro Arg Gly Asp Val
     375                 380                 385

 gat gat ccc ctc ttg gat atg aag act cca gtc ctc ttt gtc att ggt     1314
 Asp Asp Pro Leu Leu Asp Met Lys Thr Pro Val Leu Phe Val Ile Gly
 390                 395                 400                 405

 cag aat tcc ctt caa tgt cac cct gaa gcc atg gag gac ttc cgg gag     1362
 Gln Asn Ser Leu Gln Cys His Pro Glu Ala Met Glu Asp Phe Arg Glu
                 410                 415                 420

 aag att cga gct gag aac agc ttg gtg gtg gtt ggg gga gct gat gac     1410
 Lys Ile Arg Ala Glu Asn Ser Leu Val Val Val Gly Gly Ala Asp Asp
             425                 430                 435

 aat ctc aga ata agc aaa gca aag aag aaa tca gaa ggg ttg act cag     1458
 Asn Leu Arg Ile Ser Lys Ala Lys Lys Lys Ser Glu Gly Leu Thr Gln
         440                 445                 450

 agc atg gtg gac aga tgt att cag gat gag att gtg gac ttt ctg act     1506
 Ser Met Val Asp Arg Cys Ile Gln Asp Glu Ile Val Asp Phe Leu Thr
     455                 460                 465

 gga gtg ctc act cgt gct gag ggt cac atg ggc tct gaa cct cgg gat     1554
 Gly Val Leu Thr Arg Ala Glu Gly His Met Gly Ser Glu Pro Arg Asp
 470                 475                 480                 485

 cag gat gct gag aag aag aag aag ccc cgc gat gtg gcc cgc aga gac     1602
 Gln Asp Ala Glu Lys Lys Lys Lys Pro Arg Asp Val Ala Arg Arg Asp
                 490                 495                 500

 ttg gcc ttt gaa gtc cct gag cgg ggc agt cga cct gcc tcc cca gct     1650
 Leu Ala Phe Glu Val Pro Glu Arg Gly Ser Arg Pro Ala Ser Pro Ala
             505                 510                 515

 gcc aag ctg ccc gcc tca ccc tca ggc tca gag ggt ctc tcc agt gtg     1698
 Ala Lys Leu Pro Ala Ser Pro Ser Gly Ser Glu Gly Leu Ser Ser Val
         520                 525                 530

 tcc agc agc ccc acc tcc agt ccc aag acc aaa gtg acc aca gtg acc     1746
 Ser Ser Ser Pro Thr Ser Ser Pro Lys Thr Lys Val Thr Thr Val Thr
     535                 540                 545

 tct gcc cag aag tcc agt cag att gga agt tct cag ctg ctg aag aga     1794
 Ser Ala Gln Lys Ser Ser Gln Ile Gly Ser Ser Gln Leu Leu Lys Arg
 550                 555                 560                 565

 cat gtg cag cgg aca gaa gct gtg ctg acc cac aaa caa gct caa gtt     1842
 His Val Gln Arg Thr Glu Ala Val Leu Thr His Lys Gln Ala Gln Val
                 570                 575                 580

 ccc att tca tca gaa cca cca gag gaa gga gag aaa gag gat ctt agg     1890
 Pro Ile Ser Ser Glu Pro Pro Glu Glu Gly Glu Lys Glu Asp Leu Arg
             585                 590                 595

 gtt cag ctg aag cga cac cat ccc tcg agt ccc ctt cct gtc tac tct     1938
 Val Gln Leu Lys Arg His His Pro Ser Ser Pro Leu Pro Val Tyr Ser
         600                 605                 610

 tgg ttt cac cac tag aacagtcttg ggctggatgg gttatagagc tgagcggctg     1993
 Trp Phe His His 
     615

 tgatggttct gtttttacat taacaaaaac aattaaaaac accaaaaaca ac           2045




      <210> 549
      <211> 801
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (1)..(801)

      <400> 549
  atg cac tcc tcc tta aag cct act caa ccc tgg ggt ctg cag gca agt      48
  Met His Ser Ser Leu Lys Pro Thr Gln Pro Trp Gly Leu Gln Ala Ser
    1               5                  10                  15

 tcc tcg cgg gtg cct tcc ctt gtc ctg gct gct gct ctg ctt cct ttg       96
 Ser Ser Arg Val Pro Ser Leu Val Leu Ala Ala Ala Leu Leu Pro Leu
              20                  25                  30

 caa gct cct tct cgc acc ctt gcg ctg gct ccc tcc aga ggg ctc cat      144
 Gln Ala Pro Ser Arg Thr Leu Ala Leu Ala Pro Ser Arg Gly Leu His
          35                  40                  45

 ccc ctg ccc act gtg cct tcg tgg gtg gtg ccc aga tct ctg tct cct      192
 Pro Leu Pro Thr Val Pro Ser Trp Val Val Pro Arg Ser Leu Ser Pro
      50                  55                  60

 ctg ccc tgg acc cct ctg ccc ctg act ggc aga tct ata gag ttc aat      240
 Leu Pro Trp Thr Pro Leu Pro Leu Thr Gly Arg Ser Ile Glu Phe Asn
  65                  70                  75                  80

 gcc cct gga ggg ctc cac gtc cat ccc aca ggg acc cgg act ctc atc      288
 Ala Pro Gly Gly Leu His Val His Pro Thr Gly Thr Arg Thr Leu Ile
                  85                  90                  95

 ttc ctc ctg agt gtg ctc tcc ccg gag acc tgg cat tgg aat tca ccc      336
 Phe Leu Leu Ser Val Leu Ser Pro Glu Thr Trp His Trp Asn Ser Pro
             100                 105                 110

 tgc cac ctt gtg gtc tcc cca agt gga aac ctg ggc gtc agt ctg gac      384
 Cys His Leu Val Val Ser Pro Ser Gly Asn Leu Gly Val Ser Leu Asp
         115                 120                 125

 gct tgt cac caa att ctg tcc ctt cca cct tca cat ggc ctc tcc atc      432
 Ala Cys His Gln Ile Leu Ser Leu Pro Pro Ser His Gly Leu Ser Ile
     130                 135                 140

 ttc acc gcc tcg gtg tct cta tct cgt ccc gat cac cgt cgc ctc tcc      480
 Phe Thr Ala Ser Val Ser Leu Ser Arg Pro Asp His Arg Arg Leu Ser
 145                 150                 155                 160

 tct ggc gga gag cac cag cat tcc cac tgg tct ctg ctt ttc ctc aaa      528
 Ser Gly Gly Glu His Gln His Ser His Trp Ser Leu Leu Phe Leu Lys
                 165                 170                 175

 cgc atc tct gtg tat atc tcc cct cag gat cac tct gtg gcc ccc act      576
 Arg Ile Ser Val Tyr Ile Ser Pro Gln Asp His Ser Val Ala Pro Thr
             180                 185                 190

 gct ctg ggt gga acc ttc ttt cca gtg gtg ttt cag tcc cct ggg tct      624
 Ala Leu Gly Gly Thr Phe Phe Pro Val Val Phe Gln Ser Pro Gly Ser
         195                 200                 205

 gcc tca ctc ctc acc acc gtc ttg tgc ttc tgc act gag ctc cag cca      672
 Ala Ser Leu Leu Thr Thr Val Leu Cys Phe Cys Thr Glu Leu Gln Pro
     210                 215                 220

 gac cac ctg cct gca gcc acc tgg cac tac ctg ttc ccg tgt gct tcc      720
 Asp His Leu Pro Ala Ala Thr Trp His Tyr Leu Phe Pro Cys Ala Ser
 225                 230                 235                 240

 tgc ctt tgc ctg gag aga ata aca atc tat agt cca aac tca agg aca      768
 Cys Leu Cys Leu Glu Arg Ile Thr Ile Tyr Ser Pro Asn Ser Arg Thr
                 245                 250                 255

 aaa aca aac tgc ttt ttg gct gtg gtg gca tga                          801
 Lys Thr Asn Cys Phe Leu Ala Val Val Ala 
             260                 265





      <210> 550
      <211> 1115
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (355)..(741)

      <400> 550
 aatcccccta tgaccgggaa aaaggaaaat ttatcccaca aagttatttc cattttggga     60

 aaggcctaaa aaataatccc acatcttttc aaaaccctat aagcttggcc accaagaacg    120

 gtttcaacct gtgtgaagaa tttttttttg ggaccaatta gtagcacaca tgaaagaatg    180

 atcacttctt tattctctcc actctcttca gttgtagggt ccctaaaggt aaaataacta    240

 atacaaaaca aattttaaaa agtggaagct ttttctttcc tctccacctt ttggccattt    300

 ttgtttttat taggacagac aggataaaag aaaaatgaag ctcaaatata actg  atg     357
                                                              Met
                                                                1

 ctt gtt agc aat tta aaa aga caa ttt aaa ctg ttt tat aaa atc aga      405
 Leu Val Ser Asn Leu Lys Arg Gln Phe Lys Leu Phe Tyr Lys Ile Arg
               5                  10                  15

 tat tta ata ttt gga tca gat atg tgg gag ggg gga agg cta tat att      453
 Tyr Leu Ile Phe Gly Ser Asp Met Trp Glu Gly Gly Arg Leu Tyr Ile
          20                  25                  30

 ttt gga ctt ctt cct ttt tgt cat ata aag ctc caa att gat ttt atc      501
 Phe Gly Leu Leu Pro Phe Cys His Ile Lys Leu Gln Ile Asp Phe Ile
      35                  40                  45

 ttt gtt gtt ttt gtg gat gga ggt gag tac tac aaa att gac caa ttt      549
 Phe Val Val Phe Val Asp Gly Gly Glu Tyr Tyr Lys Ile Asp Gln Phe
  50                  55                  60                  65

 agt atg tca ggg aat gaa gag gtt ccc tgg tca atg tta cag cct ggt      597
 Ser Met Ser Gly Asn Glu Glu Val Pro Trp Ser Met Leu Gln Pro Gly
                  70                  75                  80

 tcc tgg aaa aag agc ctg caa gcg tgc att gct aat tcc cat tca cac      645
 Ser Trp Lys Lys Ser Leu Gln Ala Cys Ile Ala Asn Ser His Ser His
              85                  90                  95

 act gac ttg gca caa ttt gct gtg ctg ttg tat gca atg atc tgc atc      693
 Thr Asp Leu Ala Gln Phe Ala Val Leu Leu Tyr Ala Met Ile Cys Ile
         100                 105                 110

 aat gac act ggc caa ggg aga agc aga aac aga aat gag gac atg taa      741
 Asn Asp Thr Gly Gln Gly Arg Ser Arg Asn Arg Asn Glu Asp Met 
     115                 120                 125

 ctttcaagaa aggaagagta tcattaaaat gaaaatttct ctgttgcaaa catcagagaa    801

 aatgtgcaat cccaggccaa taagcaaatc tttgcccaaa ataaacatat ttcttctgct    861

 acatctcact gcggccctta gaaaaaccgt accaatgact tatcttactg gaggtgttaa    921

 taccaccaac atattttatt ccttccttca gtttttccag tttctttacc agcagtatct    981

 gaacttttca tttaggaaac accattcttc atggtgctta tgaaaacagg aggtgcctga   1041

 aggaggctga gaagaggttc gcagcttcta ctgtccttga taggggaggg gaggggagac   1101

 tgcatgccat ctga                                                     1115




      <210> 551
      <211> 1657
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (1)..(1392)

      <400> 551
  atg gac aaa gga ttc ccg cag aga gtg gta aaa cac ttt cct gga atc      48
  Met Asp Lys Gly Phe Pro Gln Arg Val Val Lys His Phe Pro Gly Ile
    1               5                  10                  15

 agt atc cgt gtt gat gct gct ttc cag tac aaa gct cat ggg gac tcc       96
 Ser Ile Arg Val Asp Ala Ala Phe Gln Tyr Lys Ala His Gly Asp Ser
              20                  25                  30

 tac cca ttt gat ggg cca gga aac acg ctg gct cat gcc ttt gcg cct      144
 Tyr Pro Phe Asp Gly Pro Gly Asn Thr Leu Ala His Ala Phe Ala Pro
          35                  40                  45

 ggg aca ggt ctc gga gga gat gct cac ttc gat gag gat gaa cgc tgg      192
 Gly Thr Gly Leu Gly Gly Asp Ala His Phe Asp Glu Asp Glu Arg Trp
      50                  55                  60

 acg gat ggt agc agt cta gaa ggg aat cat ctt gtt caa agc aac aat      240
 Thr Asp Gly Ser Ser Leu Glu Gly Asn His Leu Val Gln Ser Asn Asn
  65                  70                  75                  80

 agg agt ttc ata gat gac aaa att cgg gaa atg caa gca ttt ttt gga      288
 Arg Ser Phe Ile Asp Asp Lys Ile Arg Glu Met Gln Ala Phe Phe Gly
                  85                  90                  95

 ttg aca gtg act gga aaa ctg gac tca aac acc ctt gag atc atg aag      336
 Leu Thr Val Thr Gly Lys Leu Asp Ser Asn Thr Leu Glu Ile Met Lys
             100                 105                 110

 aca ccc agg tgt ggg gtg cct gat gtg ggc cag tat ggc tac acc ctc      384
 Thr Pro Arg Cys Gly Val Pro Asp Val Gly Gln Tyr Gly Tyr Thr Leu
         115                 120                 125

 cct ggg tgg aga aaa tac aac ctc acc tac aga ata ata aac tat act      432
 Pro Gly Trp Arg Lys Tyr Asn Leu Thr Tyr Arg Ile Ile Asn Tyr Thr
     130                 135                 140

 ccg gat atg gca cga gct gct gtg gat gag gct atc caa gaa ggt tta      480
 Pro Asp Met Ala Arg Ala Ala Val Asp Glu Ala Ile Gln Glu Gly Leu
 145                 150                 155                 160

 gaa gtg tgg agc aaa gtc act cca cta aaa ttc acc aag att tca aag      528
 Glu Val Trp Ser Lys Val Thr Pro Leu Lys Phe Thr Lys Ile Ser Lys
                 165                 170                 175

 ggg att gca gac atc atg att gcc ttt agg act cga gtc cat ggt cgg      576
 Gly Ile Ala Asp Ile Met Ile Ala Phe Arg Thr Arg Val His Gly Arg
             180                 185                 190

 tgt cct cgc tat ttt gat ggt ccc ttg gga gtt ctt ggc cat gcc ttt      624
 Cys Pro Arg Tyr Phe Asp Gly Pro Leu Gly Val Leu Gly His Ala Phe
         195                 200                 205

 cct cct ggt ccg ggt ctg ggt ggt gac act cat ttt gat gag gat gaa      672
 Pro Pro Gly Pro Gly Leu Gly Gly Asp Thr His Phe Asp Glu Asp Glu
     210                 215                 220

 aac tgg acc aag gat gga gca gga ttc aac ttg ttt ctt gtg gct gct      720
 Asn Trp Thr Lys Asp Gly Ala Gly Phe Asn Leu Phe Leu Val Ala Ala
 225                 230                 235                 240

 cat gaa ttt ggt cat gca ctg ggg ctc tct cac tcc tct gac cct ggt      768
 His Glu Phe Gly His Ala Leu Gly Leu Ser His Ser Ser Asp Pro Gly
                 245                 250                 255

 gcc ttg atg tat ccc aac tat gct ttc agg gaa acc agc aac tac tca      816
 Ala Leu Met Tyr Pro Asn Tyr Ala Phe Arg Glu Thr Ser Asn Tyr Ser
             260                 265                 270

 ctc cct caa gat gac atc gat ggc att cag gcc atc tat gga ctt tca      864
 Leu Pro Gln Asp Asp Ile Asp Gly Ile Gln Ala Ile Tyr Gly Leu Ser
         275                 280                 285

 agc aac cct atc caa cct act gga cca agc aca ccc aaa ccc tgt gac      912
 Ser Asn Pro Ile Gln Pro Thr Gly Pro Ser Thr Pro Lys Pro Cys Asp
     290                 295                 300

 ccc agt ttg aca ttt gat gct atc acc aca ctc cgt gga gaa ata ctt      960
 Pro Ser Leu Thr Phe Asp Ala Ile Thr Thr Leu Arg Gly Glu Ile Leu
 305                 310                 315                 320

 ttc ttt aaa gac aga tat gat aac caa aga caa ttc atg gag cca ggt     1008
 Phe Phe Lys Asp Arg Tyr Asp Asn Gln Arg Gln Phe Met Glu Pro Gly
                 325                 330                 335

 tat ccc aaa agc ata tca ggt gcc ttt cca gga ata gag agt aaa gtt     1056
 Tyr Pro Lys Ser Ile Ser Gly Ala Phe Pro Gly Ile Glu Ser Lys Val
             340                 345                 350

 gat gca gtt ttc cag caa gaa cag gag aca ggg tct tac tat gct gac     1104
 Asp Ala Val Phe Gln Gln Glu Gln Glu Thr Gly Ser Tyr Tyr Ala Asp
         355                 360                 365

 cag att tct tcc atg tct tca gtg gac caa gat att acg cat ttg atc     1152
 Gln Ile Ser Ser Met Ser Ser Val Asp Gln Asp Ile Thr His Leu Ile
     370                 375                 380

 tta ttg ctc aga gag tta cca gag ttg caa gag gca ata aat ggc tta     1200
 Leu Leu Leu Arg Glu Leu Pro Glu Leu Gln Glu Ala Ile Asn Gly Leu
 385                 390                 395                 400

 act gta gat atg gct gaa gca aaa tca aat gtg gct gta tcc act ttc     1248
 Thr Val Asp Met Ala Glu Ala Lys Ser Asn Val Ala Val Ser Thr Phe
                 405                 410                 415

 aga atg ttg aag gga agt tca gca agc att ttc gtt aca ttg tgt cct     1296
 Arg Met Leu Lys Gly Ser Ser Ala Ser Ile Phe Val Thr Leu Cys Pro
             420                 425                 430

 gct tat act ttt ctc aat att aag tca ttg ttt ccc atc act gta tcc     1344
 Ala Tyr Thr Phe Leu Asn Ile Lys Ser Leu Phe Pro Ile Thr Val Ser
         435                 440                 445

 att cta cct gtc ctc cgt gaa aat atg ttt gga ata ttc cac tat tga     1392
 Ile Leu Pro Val Leu Arg Glu Asn Met Phe Gly Ile Phe His Tyr 
     450                 455                 460

 ggaatgaagc gccttctgct tctgtttttg ttctttataa cattttcttc tgcatttccc   1452

 ttagtccgga tgatggaaaa tgaagaaaat atgcaactgg ctcaggcata tctcaaccag   1512

 ttctactctc ttgaaataga agggaatcat cttgttcaaa gcaagaatag gagtctcata   1572

 gatgacaaaa ttcgggaaat gcaagcattt tttggattga cagtgactgg aaaactggac   1632

 tcaaacaccc ttgagatcat gaaga                                         1657




      <210> 552
      <211> 2454
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (1)..(2454)

      <400> 552
  atg agg caa gtt ttt acc ata aag gca ttt gat aaa tca ggt gga aaa      48
  Met Arg Gln Val Phe Thr Ile Lys Ala Phe Asp Lys Ser Gly Gly Lys
    1               5                  10                  15

 cag cct tgc ata ata ctt ttg gat gaa aac gaa gtc cag aga ctg ctg       96
 Gln Pro Cys Ile Ile Leu Leu Asp Glu Asn Glu Val Gln Arg Leu Leu
              20                  25                  30

 gac ata ctg agt ccg aag aga agc ccc cag caa aaa gtt gga gct cta      144
 Asp Ile Leu Ser Pro Lys Arg Ser Pro Gln Gln Lys Val Gly Ala Leu
          35                  40                  45

 aag gat ttt gtc ctc agt ata agg gag ggt ggg gtc gta gca ctc ttc      192
 Lys Asp Phe Val Leu Ser Ile Arg Glu Gly Gly Val Val Ala Leu Phe
      50                  55                  60

 aag gtt tgc cgg cag gac agt ttc cgg tgc ttg tac ccc cag gcg ctc      240
 Lys Val Cys Arg Gln Asp Ser Phe Arg Cys Leu Tyr Pro Gln Ala Leu
  65                  70                  75                  80

 cgc acg ctg gcc tcc atc tgc tgc gtg gaa gag ggt gtc cac cag ctg      288
 Arg Thr Leu Ala Ser Ile Cys Cys Val Glu Glu Gly Val His Gln Leu
                  85                  90                  95

 gag aag agc tgt cac gtg gag gtc tgg ttc atc tgg gct gca gcc tcc      336
 Glu Lys Ser Cys His Val Glu Val Trp Phe Ile Trp Ala Ala Ala Ser
             100                 105                 110

 ctg cat cct aag ctt cag gac atc tgt cct tcc ttc cct gtg tct tca      384
 Leu His Pro Lys Leu Gln Asp Ile Cys Pro Ser Phe Pro Val Ser Ser
         115                 120                 125

 tct gac atc act cct cat tcc cta ccc cta tgc tgg gtt ctg gag aag      432
 Ser Asp Ile Thr Pro His Ser Leu Pro Leu Cys Trp Val Leu Glu Lys
     130                 135                 140

 aga cag gct ccc tgc ttc cca gga tgg ctg aag ggg gag agg ccc agc      480
 Arg Gln Ala Pro Cys Phe Pro Gly Trp Leu Lys Gly Glu Arg Pro Ser
 145                 150                 155                 160

 agg aca gac agt ggc tgg tct ggg gaa aac ttc aca ttg ccc cca aag      528
 Arg Thr Asp Ser Gly Trp Ser Gly Glu Asn Phe Thr Leu Pro Pro Lys
                 165                 170                 175

 gac ctg gtt att ggg gat ttt gca atg acc atg gca ggg tcc aac ctg      576
 Asp Leu Val Ile Gly Asp Phe Ala Met Thr Met Ala Gly Ser Asn Leu
             180                 185                 190

 agt ttg gag aag gga tgg ggc tgc cag gca gtc cag gtg cct aag tgc      624
 Ser Leu Glu Lys Gly Trp Gly Cys Gln Ala Val Gln Val Pro Lys Cys
         195                 200                 205

 agc agt ggg ttt gca gga gca ggc tcc atc cgc aga ggc tcg gtg gga      672
 Ser Ser Gly Phe Ala Gly Ala Gly Ser Ile Arg Arg Gly Ser Val Gly
     210                 215                 220

 ccc cat gtg ctg tgc aac agc gac ccc tgg tgg ata aga aca cca gtg      720
 Pro His Val Leu Cys Asn Ser Asp Pro Trp Trp Ile Arg Thr Pro Val
 225                 230                 235                 240

 gcc gct cca tca ggc tgc ctg ggg cta cac ctg atg cag gtg gac tca      768
 Ala Ala Pro Ser Gly Cys Leu Gly Leu His Leu Met Gln Val Asp Ser
                 245                 250                 255

 gtc cag cgc tgg atg gaa gat ctg aag ctc atg acc gag tgc gag tgc      816
 Val Gln Arg Trp Met Glu Asp Leu Lys Leu Met Thr Glu Cys Glu Cys
             260                 265                 270

 atg tgt gtc ctg cag gcc aag ccc atc agc ctg gaa gag gat gca cag      864
 Met Cys Val Leu Gln Ala Lys Pro Ile Ser Leu Glu Glu Asp Ala Gln
         275                 280                 285

 ggt gac ctc atc ctg gca ggt ggc cct ggc cct gga gac ccc ctg cag      912
 Gly Asp Leu Ile Leu Ala Gly Gly Pro Gly Pro Gly Asp Pro Leu Gln
     290                 295                 300

 ctg ctg ctc aaa cgg ggt tgg gtc att agc aca gag ctg cgc agg atc      960
 Leu Leu Leu Lys Arg Gly Trp Val Ile Ser Thr Glu Leu Arg Arg Ile
 305                 310                 315                 320

 ggg cag aag ctg gcc cag gac cgc tgg gca cgg gtg cac agc atg agc     1008
 Gly Gln Lys Leu Ala Gln Asp Arg Trp Ala Arg Val His Ser Met Ser
                 325                 330                 335

 gtg cgt ctg acc tgc cat gcc cgc tcc atg gtc agc gag tac agt gct     1056
 Val Arg Leu Thr Cys His Ala Arg Ser Met Val Ser Glu Tyr Ser Ala
             340                 345                 350

 gtc agc agg aac tcc ttg aag gaa atg ggc gag att gag aag ctg cta     1104
 Val Ser Arg Asn Ser Leu Lys Glu Met Gly Glu Ile Glu Lys Leu Leu
         355                 360                 365

 atg gag aaa tgc tcg gag ctc tcg gca gtc aca gag agg tgc ctt cag     1152
 Met Glu Lys Cys Ser Glu Leu Ser Ala Val Thr Glu Arg Cys Leu Gln
     370                 375                 380

 gtt gag aat gag cat gtc ctg aag tca atg aag gcc tgc gtg agt gag     1200
 Val Glu Asn Glu His Val Leu Lys Ser Met Lys Ala Cys Val Ser Glu
 385                 390                 395                 400

 acc ctg agc atg ctg ggc cag cac ttt ggc cag ctg ctg gag ctg gcc     1248
 Thr Leu Ser Met Leu Gly Gln His Phe Gly Gln Leu Leu Glu Leu Ala
                 405                 410                 415

 ctg aca cgg gag gtt cag gcc ccc atg tca gtg cag cag gtc ctg ggt     1296
 Leu Thr Arg Glu Val Gln Ala Pro Met Ser Val Gln Gln Val Leu Gly
             420                 425                 430

 att atc acc ccc gac ccc aac aac agg aag gca ctg gtg aga aaa att     1344
 Ile Ile Thr Pro Asp Pro Asn Asn Arg Lys Ala Leu Val Arg Lys Ile
         435                 440                 445

 gat gcc tca gac aat atc tac acc aca gag tcc acc aca ggg aac ctg     1392
 Asp Ala Ser Asp Asn Ile Tyr Thr Thr Glu Ser Thr Thr Gly Asn Leu
     450                 455                 460

 ttc agc ctg acc cag gag ggg gct ccc ttg tgc cgc atc ata gcc aag     1440
 Phe Ser Leu Thr Gln Glu Gly Ala Pro Leu Cys Arg Ile Ile Ala Lys
 465                 470                 475                 480

 gag ggt ggg gtc gta gca ctc ttc aag gtt tgc cgg cag gac agt ttc     1488
 Glu Gly Gly Val Val Ala Leu Phe Lys Val Cys Arg Gln Asp Ser Phe
                 485                 490                 495

 cgg tgc ttg tac ccc cag gcg ctc cgc acg ctg gcc tcc atc tgc tgc     1536
 Arg Cys Leu Tyr Pro Gln Ala Leu Arg Thr Leu Ala Ser Ile Cys Cys
             500                 505                 510

 gtg gaa gag ggt gtc cac cag ctg gag aag gca ctg aag agg aat aag     1584
 Val Glu Glu Gly Val His Gln Leu Glu Lys Ala Leu Lys Arg Asn Lys
         515                 520                 525

 act tac cct ggc tgg tct ggg gaa aac ttc aca ttg ccc cca aag gac     1632
 Thr Tyr Pro Gly Trp Ser Gly Glu Asn Phe Thr Leu Pro Pro Lys Asp
     530                 535                 540

 ctg gtt att ggg gat ttt gca atg acc atg gca ggg tgc cag gtg gat     1680
 Leu Val Ile Gly Asp Phe Ala Met Thr Met Ala Gly Cys Gln Val Asp
 545                 550                 555                 560

 ggc gtt ctg tgc ttg gcc gac atc ctg acc gac aac agc cac tca gag     1728
 Gly Val Leu Cys Leu Ala Asp Ile Leu Thr Asp Asn Ser His Ser Glu
                 565                 570                 575

 gcc aca cgg gct gag gct gcg gct gtg gtg gcc cag gtc acc tcc cca     1776
 Ala Thr Arg Ala Glu Ala Ala Ala Val Val Ala Gln Val Thr Ser Pro
             580                 585                 590

 cac ctg ccc gtc acc cag cac ctc agt agc ttc ctg gag agc atg gag     1824
 His Leu Pro Val Thr Gln His Leu Ser Ser Phe Leu Glu Ser Met Glu
         595                 600                 605

 gag atc gtg aca gcc ctc gtc aaa ctg tgc caa gag gcc tca tca ggg     1872
 Glu Ile Val Thr Ala Leu Val Lys Leu Cys Gln Glu Ala Ser Ser Gly
     610                 615                 620

 gaa gtc ttc cta ctg gcc tct gcg gcc ctt gcc aac atc acg ttc ttt     1920
 Glu Val Phe Leu Leu Ala Ser Ala Ala Leu Ala Asn Ile Thr Phe Phe
 625                 630                 635                 640

 gac aca atg gcc tgc gag atg ctc ctg cag ttg aat gcc atc cgt gtt     1968
 Asp Thr Met Ala Cys Glu Met Leu Leu Gln Leu Asn Ala Ile Arg Val
                 645                 650                 655

 ctc ctg gaa gcc tgc agt gac aag cag aga gtg gac acg cct tac act     2016
 Leu Leu Glu Ala Cys Ser Asp Lys Gln Arg Val Asp Thr Pro Tyr Thr
             660                 665                 670

 cgg gac cag att gtg acc atc ttg gca aac atg tct gtc cta gaa cag     2064
 Arg Asp Gln Ile Val Thr Ile Leu Ala Asn Met Ser Val Leu Glu Gln
         675                 680                 685

 tgt gcc tct gac atc att cag gaa aat ggg gtc cag ctt atc atg ggc     2112
 Cys Ala Ser Asp Ile Ile Gln Glu Asn Gly Val Gln Leu Ile Met Gly
     690                 695                 700

 atg ctg tct gaa aaa cca agg tct ggg act cct gct gaa gtg gca gcc     2160
 Met Leu Ser Glu Lys Pro Arg Ser Gly Thr Pro Ala Glu Val Ala Ala
 705                 710                 715                 720

 tgt gag cga gtc cag cag aaa gct gca gtg acc ctg gct cgt ctc agc     2208
 Cys Glu Arg Val Gln Gln Lys Ala Ala Val Thr Leu Ala Arg Leu Ser
                 725                 730                 735

 cga gac cca gat gtg gca cgg gag gcc gtg cgg ctc agc tgc atg tcc     2256
 Arg Asp Pro Asp Val Ala Arg Glu Ala Val Arg Leu Ser Cys Met Ser
             740                 745                 750

 cgt ctc atc gag ctc tgc aga tcc cca tca gag agg aac agc agt gac     2304
 Arg Leu Ile Glu Leu Cys Arg Ser Pro Ser Glu Arg Asn Ser Ser Asp
         755                 760                 765

 gcc gtg ctt gtg gcc tgc ctg gct gct ctg cgt aga ttg gct ggg gtc     2352
 Ala Val Leu Val Ala Cys Leu Ala Ala Leu Arg Arg Leu Ala Gly Val
     770                 775                 780

 tgc cct gaa ggc ctc cag gac tct gac ttt cag cag ttg gtc cag cct     2400
 Cys Pro Glu Gly Leu Gln Asp Ser Asp Phe Gln Gln Leu Val Gln Pro
 785                 790                 795                 800

 cgg ctg gtg gac tcc ttc tta ctc tgc agc aac atg gag gag agt ttt     2448
 Arg Leu Val Asp Ser Phe Leu Leu Cys Ser Asn Met Glu Glu Ser Phe
                 805                 810                 815

 gtg tag                                                             2454
 Val 






      <210> 553
      <211> 384
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (1)..(384)

      <400> 553
  atg ccg ttt cgg aaa tgc agc aac cca gat gtg gct tct ggc cct gga      48
  Met Pro Phe Arg Lys Cys Ser Asn Pro Asp Val Ala Ser Gly Pro Gly
    1               5                  10                  15

 aaa tca ctg aag tat aaa aga cag ctg agt gag gat gga aga cag cta       96
 Lys Ser Leu Lys Tyr Lys Arg Gln Leu Ser Glu Asp Gly Arg Gln Leu
              20                  25                  30

 agg cga ggg agc ctg gga gga gcc ctg act ggg agg tac ctt ctt cca      144
 Arg Arg Gly Ser Leu Gly Gly Ala Leu Thr Gly Arg Tyr Leu Leu Pro
          35                  40                  45

 aac ccg gtg gcg gga cag gcc tgg ccg gcc tct gca gag acg tcc aac      192
 Asn Pro Val Ala Gly Gln Ala Trp Pro Ala Ser Ala Glu Thr Ser Asn
      50                  55                  60

 ctc gtg cgc atg cgc agc cag gcc ctg ggc cag tcg gcg ccc tcg ctc      240
 Leu Val Arg Met Arg Ser Gln Ala Leu Gly Gln Ser Ala Pro Ser Leu
  65                  70                  75                  80

 acc gcc agc ctg ctt tct ctt ttc ctt gtc ttc aaa caa att gac att      288
 Thr Ala Ser Leu Leu Ser Leu Phe Leu Val Phe Lys Gln Ile Asp Ile
                  85                  90                  95

 tgc gga ggt gcg ttg tgc agt aga aca ttc ctc atg ctg atg atc ctc      336
 Cys Gly Gly Ala Leu Cys Ser Arg Thr Phe Leu Met Leu Met Ile Leu
             100                 105                 110

 tcc tcc tgg cct ctc tgt cta ccc ctt gcc cct gtc gta gag ctg taa      384
 Ser Ser Trp Pro Leu Cys Leu Pro Leu Ala Pro Val Val Glu Leu 
         115                 120                 125





      <210> 554
      <211> 1563
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (1)..(1563)

      <400> 554
  atg gac tta gag gaa atg gca agg agc tgg tgg agg aag agg agc cag      48
  Met Asp Leu Glu Glu Met Ala Arg Ser Trp Trp Arg Lys Arg Ser Gln
    1               5                  10                  15

 gga agg aag agg tgg agt cag agt tgt agg agg aaa aat aga gga gag       96
 Gly Arg Lys Arg Trp Ser Gln Ser Cys Arg Arg Lys Asn Arg Gly Glu
              20                  25                  30

 gta tcc cag agg gtg aaa gaa ggg gaa agt ttt tgg gat gaa ggt cat      144
 Val Ser Gln Arg Val Lys Glu Gly Glu Ser Phe Trp Asp Glu Gly His
          35                  40                  45

 tca ttc aac gat gtc aaa agt agc aaa cag ctc tgt ggt agc ctt gaa      192
 Ser Phe Asn Asp Val Lys Ser Ser Lys Gln Leu Cys Gly Ser Leu Glu
      50                  55                  60

 aat caa cag ccc aca atc aca gtg aaa gcc aat agc ctg gca gcc act      240
 Asn Gln Gln Pro Thr Ile Thr Val Lys Ala Asn Ser Leu Ala Ala Thr
  65                  70                  75                  80

 gga gga ggc aca gta gta tta gag ttc ctt caa aac ctc att ccc aca      288
 Gly Gly Gly Thr Val Val Leu Glu Phe Leu Gln Asn Leu Ile Pro Thr
                  85                  90                  95

 gat ctg tca gga ttt gcc ctc tct ggg agt tcc cag gaa gac ttt aat      336
 Asp Leu Ser Gly Phe Ala Leu Ser Gly Ser Ser Gln Glu Asp Phe Asn
             100                 105                 110

 tgc aag act tta att gca gat tta ctt gat ctg aag atc acc cga tca      384
 Cys Lys Thr Leu Ile Ala Asp Leu Leu Asp Leu Lys Ile Thr Arg Ser
         115                 120                 125

 gac cgg att aga ctt ggt cct gtg ggg agg cac tgt tct aga agt aac      432
 Asp Arg Ile Arg Leu Gly Pro Val Gly Arg His Cys Ser Arg Ser Asn
     130                 135                 140

 acc gaa tct gtc ttc tcc ggc tat aga aca cca gga gtc agg gca tct      480
 Thr Glu Ser Val Phe Ser Gly Tyr Arg Thr Pro Gly Val Arg Ala Ser
 145                 150                 155                 160

 agc aac ctt cca tgg gac cca gca aaa gag gca tca caa act gct ggc      528
 Ser Asn Leu Pro Trp Asp Pro Ala Lys Glu Ala Ser Gln Thr Ala Gly
                 165                 170                 175

 aag cct gca tct cca tac tgc cca gag gcc aga cat ctc cat gga act      576
 Lys Pro Ala Ser Pro Tyr Cys Pro Glu Ala Arg His Leu His Gly Thr
             180                 185                 190

 gac agg gca gca gtc aca aat tct aac cac ccc gtg cta gat ttc tct      624
 Asp Arg Ala Ala Val Thr Asn Ser Asn His Pro Val Leu Asp Phe Ser
         195                 200                 205

 agg cat gtg gag agc cag ttt tct cat ctg caa att ggg agt gat gag      672
 Arg His Val Glu Ser Gln Phe Ser His Leu Gln Ile Gly Ser Asp Glu
     210                 215                 220

 tac ctc cct tac aag gtg gtt atg aga att aaa tgt gat cat ttg gat      720
 Tyr Leu Pro Tyr Lys Val Val Met Arg Ile Lys Cys Asp His Leu Asp
 225                 230                 235                 240

 acc cct gta tct gct gac agt atc tct tct gct tct tct cca cga cgt      768
 Thr Pro Val Ser Ala Asp Ser Ile Ser Ser Ala Ser Ser Pro Arg Arg
                 245                 250                 255

 gag acc ctc gag aac agg gac cat ttc tct gcc agg gac agt gaa agc      816
 Glu Thr Leu Glu Asn Arg Asp His Phe Ser Ala Arg Asp Ser Glu Ser
             260                 265                 270

 ctg gcg cag gac gat gcc cca tca ttg ctt cct gaa tgc acc tct agc      864
 Leu Ala Gln Asp Asp Ala Pro Ser Leu Leu Pro Glu Cys Thr Ser Ser
         275                 280                 285

 gta gtg atc ctg aca gcc act aaa tct gtg ttg ctg agt ctg ctg ttt      912
 Val Val Ile Leu Thr Ala Thr Lys Ser Val Leu Leu Ser Leu Leu Phe
     290                 295                 300

 gca tgc agg aat gtg aag gac tgc tca agt tgg aga tac aaa ttg aag      960
 Ala Cys Arg Asn Val Lys Asp Cys Ser Ser Trp Arg Tyr Lys Leu Lys
 305                 310                 315                 320

 cca gcc cca gtt caa aac tgt tac aaa tgg agt ctg cag aga gta gtg     1008
 Pro Ala Pro Val Gln Asn Cys Tyr Lys Trp Ser Leu Gln Arg Val Val
                 325                 330                 335

 acc cag gtc acc cct gtg aca cca tgg gga cca tgt cag aaa cgg aaa     1056
 Thr Gln Val Thr Pro Val Thr Pro Trp Gly Pro Cys Gln Lys Arg Lys
             340                 345                 350

 tgt gcc att atg ggg caa cta aag aag cct gtc atc tct cag gca gtg     1104
 Cys Ala Ile Met Gly Gln Leu Lys Lys Pro Val Ile Ser Gln Ala Val
         355                 360                 365

 ttt gtt ggc act ggt ccc aaa cac ctg gtt aat ttc ttc tct gcc aac     1152
 Phe Val Gly Thr Gly Pro Lys His Leu Val Asn Phe Phe Ser Ala Asn
     370                 375                 380

 agt gat aat aat gtg cgt gct tcc cat cta act cat gga gtt gcc acg     1200
 Ser Asp Asn Asn Val Arg Ala Ser His Leu Thr His Gly Val Ala Thr
 385                 390                 395                 400

 tgg agg aaa cat aag att ttc aca tcc agt tca gag gaa tgt caa gaa     1248
 Trp Arg Lys His Lys Ile Phe Thr Ser Ser Ser Glu Glu Cys Gln Glu
                 405                 410                 415

 ttt att tta cat gca gtt gaa aag ttg atg ctg caa gaa ccc agg act     1296
 Phe Ile Leu His Ala Val Glu Lys Leu Met Leu Gln Glu Pro Arg Thr
             420                 425                 430

 cag aat cag gct gag gac agg ctc tta gat gag gga aaa gca gag aag     1344
 Gln Asn Gln Ala Glu Asp Arg Leu Leu Asp Glu Gly Lys Ala Glu Lys
         435                 440                 445

 ggc ctt ctg cag atc aga atc cca ttg gcc ttt gtc act gaa gta gca     1392
 Gly Leu Leu Gln Ile Arg Ile Pro Leu Ala Phe Val Thr Glu Val Ala
     450                 455                 460

 atg ctt ctc ctc ttg tat gca atg ggt agt ctc cga gcc cag agt gac     1440
 Met Leu Leu Leu Leu Tyr Ala Met Gly Ser Leu Arg Ala Gln Ser Asp
 465                 470                 475                 480

 ctg cag agt ctc aga aca cag tcc acc ttc agc tct gtc agt cct tcg     1488
 Leu Gln Ser Leu Arg Thr Gln Ser Thr Phe Ser Ser Val Ser Pro Ser
                 485                 490                 495

 agg atg cag caa caa ggg acc att ttg gaa gca gag agc agc ccc cac     1536
 Arg Met Gln Gln Gln Gly Thr Ile Leu Glu Ala Glu Ser Ser Pro His
             500                 505                 510

 cag aca cca atc ctg ctg gca cct tga                                 1563
 Gln Thr Pro Ile Leu Leu Ala Pro 
         515                 520





      <210> 555
      <211> 2205
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (319)..(2205)

      <400> 555
 atggccgtag gacagacact ggccttgtac agtcagaaga agcacaagga caggtggctt     60

 gcagccctga gtgatcgaga gactcggctg caggaggtgc gctcagcctt cttggctgcg    120

 tacagcagca cagtggggct tcgggcagta gcccccagtc cttccggtgc catcgggggc    180

 ctgctggagc aatttgcccc gcatgagcca ccgtacctga ccaggatctt catctttaac    240

 aagttctgta ggcagcaggg tcctgcccca gcagccctgg tctcgcagcc tcctgcggct    300

 ctggtcgccc gaccagcc  atg tct ctc ggc gga gcc tcc gag cgc agc gtc     351
                      Met Ser Leu Gly Gly Ala Ser Glu Arg Ser Val
                        1               5                  10

 ccg gcc acc aag att gaa att acc gtg tcc tgc cgg aac ctg cta gac      399
 Pro Ala Thr Lys Ile Glu Ile Thr Val Ser Cys Arg Asn Leu Leu Asp
              15                  20                  25

 ctt gat acc ttc tcc aag tcc gac ccc atg gtg gtg ctt tac acg cag      447
 Leu Asp Thr Phe Ser Lys Ser Asp Pro Met Val Val Leu Tyr Thr Gln
          30                  35                  40

 agc cgg gcc agc cag gag tgg cgg gag ggc gtc gcc cgg gaa ttc ccc      495
 Ser Arg Ala Ser Gln Glu Trp Arg Glu Gly Val Ala Arg Glu Phe Pro
      45                  50                  55

 tgc ccg tct gca cgt ccc acg ctg acc ctc cac ccc cct acc cag ttc      543
 Cys Pro Ser Ala Arg Pro Thr Leu Thr Leu His Pro Pro Thr Gln Phe
  60                  65                  70                  75

 gga cgg acc gag gtg att gat aac acg ctg aac cca gac ttc gtg cgc      591
 Gly Arg Thr Glu Val Ile Asp Asn Thr Leu Asn Pro Asp Phe Val Arg
                  80                  85                  90

 aaa ttc gtc ctc gac tat ttc ttt gag gaa aag caa aat ctg cgc ttc      639
 Lys Phe Val Leu Asp Tyr Phe Phe Glu Glu Lys Gln Asn Leu Arg Phe
              95                 100                 105

 gat gtg tac aac gtg gac tcc aaa acc aac atc tcc aaa ccg gtg agc      687
 Asp Val Tyr Asn Val Asp Ser Lys Thr Asn Ile Ser Lys Pro Val Ser
         110                 115                 120

 aaa cgt ttc ctc gag ggc ccc caa ccc acc ctc ctg gtc cct ctc ctc      735
 Lys Arg Phe Leu Glu Gly Pro Gln Pro Thr Leu Leu Val Pro Leu Leu
     125                 130                 135

 ctg cct gag tgt cct gcc tgt gcc ccc tac tca ctg ttc ctc ttc ctt      783
 Leu Pro Glu Cys Pro Ala Cys Ala Pro Tyr Ser Leu Phe Leu Phe Leu
 140                 145                 150                 155

 ctt ggc tgc cac tgc tgg gac ctg cag aag gat ttc ctg gga caa gcg      831
 Leu Gly Cys His Cys Trp Asp Leu Gln Lys Asp Phe Leu Gly Gln Ala
                 160                 165                 170

 ttc ctg gcc ctg gga gag gtg att gga ggc cag ggc agc cga gta gag      879
 Phe Leu Ala Leu Gly Glu Val Ile Gly Gly Gln Gly Ser Arg Val Glu
             175                 180                 185

 cga acc ctc acg ggt gta cca ggc aag aag tgt ggg acc ata ttg ctg      927
 Arg Thr Leu Thr Gly Val Pro Gly Lys Lys Cys Gly Thr Ile Leu Leu
         190                 195                 200

 act gca gaa gag ctt agc aat tgt cgg gac att gcc acc atg cag ctg      975
 Thr Ala Glu Glu Leu Ser Asn Cys Arg Asp Ile Ala Thr Met Gln Leu
     205                 210                 215

 tgt gca aac aag ctg gac aag aag gac ttc ttt ggg aaa tca gac ccc     1023
 Cys Ala Asn Lys Leu Asp Lys Lys Asp Phe Phe Gly Lys Ser Asp Pro
 220                 225                 230                 235

 ttc ctt gtg ttc tac agg agc aat gag gat ggc acg ttc acc atc tgc     1071
 Phe Leu Val Phe Tyr Arg Ser Asn Glu Asp Gly Thr Phe Thr Ile Cys
                 240                 245                 250

 cac aag aca gag gtt gtg aaa aac acg ctg aat cct gtg tgg cag ccc     1119
 His Lys Thr Glu Val Val Lys Asn Thr Leu Asn Pro Val Trp Gln Pro
             255                 260                 265

 ttc agc atc cct gtg cgg gct ctg tgc aat gga gac tat gac aga acg     1167
 Phe Ser Ile Pro Val Arg Ala Leu Cys Asn Gly Asp Tyr Asp Arg Thr
         270                 275                 280

 gtg aag att gat gtg tac gac tgg gac cgg gat gga agc cac gat ttc     1215
 Val Lys Ile Asp Val Tyr Asp Trp Asp Arg Asp Gly Ser His Asp Phe
     285                 290                 295

 att ggt gag ttc acc acc agc tac cgg gag ctg agc aag gcc cag aac     1263
 Ile Gly Glu Phe Thr Thr Ser Tyr Arg Glu Leu Ser Lys Ala Gln Asn
 300                 305                 310                 315

 cag ttc aca gta tat gag gtt ctt aac cct cgg aag aaa tgt aag aag     1311
 Gln Phe Thr Val Tyr Glu Val Leu Asn Pro Arg Lys Lys Cys Lys Lys
                 320                 325                 330

 aag aaa tat gtc aac tca gga act gtg acg ctg ctc tcc ttc tct gtg     1359
 Lys Lys Tyr Val Asn Ser Gly Thr Val Thr Leu Leu Ser Phe Ser Val
             335                 340                 345

 gac tct gaa ttc act ttt gtt gat tac atc aag gga ggg aca cag ctg     1407
 Asp Ser Glu Phe Thr Phe Val Asp Tyr Ile Lys Gly Gly Thr Gln Leu
         350                 355                 360

 aac ttc aca gta gcc att gac ttc acg gct tcc aat ggt gag aca cgg     1455
 Asn Phe Thr Val Ala Ile Asp Phe Thr Ala Ser Asn Gly Glu Thr Arg
     365                 370                 375

 atg agt gaa aaa gtc gga ggg aat cct ctg cag cct acc tcc ctg cac     1503
 Met Ser Glu Lys Val Gly Gly Asn Pro Leu Gln Pro Thr Ser Leu His
 380                 385                 390                 395

 tac atg agt ccc tac cag ctc agc gcc tat gcc atg gcc ctc aag gca     1551
 Tyr Met Ser Pro Tyr Gln Leu Ser Ala Tyr Ala Met Ala Leu Lys Ala
                 400                 405                 410

 gtg gga gag atc atc cag gac tat gac agt gat aag ctc ttc cca gct     1599
 Val Gly Glu Ile Ile Gln Asp Tyr Asp Ser Asp Lys Leu Phe Pro Ala
             415                 420                 425

 tat ggc ttt ggg gcc aag ctg ccc cca gag gga cgg atc tcc cac cag     1647
 Tyr Gly Phe Gly Ala Lys Leu Pro Pro Glu Gly Arg Ile Ser His Gln
         430                 435                 440

 ttc ccc ctg aac aac aat gat gag gac ccc aac tgt gcg ggc atc gag     1695
 Phe Pro Leu Asn Asn Asn Asp Glu Asp Pro Asn Cys Ala Gly Ile Glu
     445                 450                 455

 ggt gtg ctg gag agc tat ttc cag agc ctg cgc aca gtg cag ctc tat     1743
 Gly Val Leu Glu Ser Tyr Phe Gln Ser Leu Arg Thr Val Gln Leu Tyr
 460                 465                 470                 475

 ggg ccc acc tac ttt gct cct gtc atc aac caa gtg gcc agg gct gca     1791
 Gly Pro Thr Tyr Phe Ala Pro Val Ile Asn Gln Val Ala Arg Ala Ala
                 480                 485                 490

 gcc aag atc tct gat ggc tcc cag tac tat gtt ctg ctc atc atc act     1839
 Ala Lys Ile Ser Asp Gly Ser Gln Tyr Tyr Val Leu Leu Ile Ile Thr
             495                 500                 505

 gat ggg gtc atc tct gac atg acg cag acc aag gag gcc atc gtc agc     1887
 Asp Gly Val Ile Ser Asp Met Thr Gln Thr Lys Glu Ala Ile Val Ser
         510                 515                 520

 gcc tcc tca ttg ccc atg tct atc att atc gtc ggt gta gga cca gcc     1935
 Ala Ser Ser Leu Pro Met Ser Ile Ile Ile Val Gly Val Gly Pro Ala
     525                 530                 535

 atg ttt gag gca atg gaa gag ttg gac ggt gat gat gtg cgc gtg tcc     1983
 Met Phe Glu Ala Met Glu Glu Leu Asp Gly Asp Asp Val Arg Val Ser
 540                 545                 550                 555

 tct agg gga cgc tac gca gag cgg gac atc gtt cag ttc gtc cca ttc     2031
 Ser Arg Gly Arg Tyr Ala Glu Arg Asp Ile Val Gln Phe Val Pro Phe
                 560                 565                 570

 cga gac tat gtt gac cgg tcg ggg aac cag gtg ttg agc atg gcc cga     2079
 Arg Asp Tyr Val Asp Arg Ser Gly Asn Gln Val Leu Ser Met Ala Arg
             575                 580                 585

 ctg gcc aag gat gtg ctg gcc gag atc ccg gag cag ctg ctg tcc tat     2127
 Leu Ala Lys Asp Val Leu Ala Glu Ile Pro Glu Gln Leu Leu Ser Tyr
         590                 595                 600

 atg cgc acc aga gac atc cag cct cgg ccc cca ccc cct gcc aac ccc     2175
 Met Arg Thr Arg Asp Ile Gln Pro Arg Pro Pro Pro Pro Ala Asn Pro
     605                 610                 615

 agc ccg atc cca gct cca gag cag ccc tga                             2205
 Ser Pro Ile Pro Ala Pro Glu Gln Pro 
 620                 625







      <210> 556
      <211> 618
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (1)..(618)

      <400> 556
  atg ttt cgt ctg aac tca ctt tct gct ttg gca gaa ctg gct gtg ggt      48
  Met Phe Arg Leu Asn Ser Leu Ser Ala Leu Ala Glu Leu Ala Val Gly
    1               5                  10                  15

 tct cga tgg tac cat gga gga tca cag ccc atc cag atc cgg cga aga       96
 Ser Arg Trp Tyr His Gly Gly Ser Gln Pro Ile Gln Ile Arg Arg Arg
              20                  25                  30

 cta atg atg gtg gct ttc ctg gga gca tct gca gta act gca agt act      144
 Leu Met Met Val Ala Phe Leu Gly Ala Ser Ala Val Thr Ala Ser Thr
          35                  40                  45

 ggt ctt ttg tgg aag agg gcc cat gca gaa tct cca cca tgt gta gac      192
 Gly Leu Leu Trp Lys Arg Ala His Ala Glu Ser Pro Pro Cys Val Asp
      50                  55                  60

 aac cta aaa agt gac atc ggt gat aaa ggg aag aat aaa gat gaa ggg      240
 Asn Leu Lys Ser Asp Ile Gly Asp Lys Gly Lys Asn Lys Asp Glu Gly
  65                  70                  75                  80

 gat gtt tgt aac cat gag aaa aag act gca gat ctt gcc cct cac cca      288
 Asp Val Cys Asn His Glu Lys Lys Thr Ala Asp Leu Ala Pro His Pro
                  85                  90                  95

 gaa gag aaa aag aag aaa cgt tct gga ttc aga gac aga aaa gtg atg      336
 Glu Glu Lys Lys Lys Lys Arg Ser Gly Phe Arg Asp Arg Lys Val Met
             100                 105                 110

 gaa tat gag aat agg att cga gcc tac tcc acg cca gac aaa atc ttc      384
 Glu Tyr Glu Asn Arg Ile Arg Ala Tyr Ser Thr Pro Asp Lys Ile Phe
         115                 120                 125

 cga tat ttt gcc acc ttg aaa gtc atc agt gag cct ggt gaa gca gaa      432
 Arg Tyr Phe Ala Thr Leu Lys Val Ile Ser Glu Pro Gly Glu Ala Glu
     130                 135                 140

 gtg ttt atg aca cca gaa gat ttt gtg cga tcc ata aca ccc aat gaa      480
 Val Phe Met Thr Pro Glu Asp Phe Val Arg Ser Ile Thr Pro Asn Glu
 145                 150                 155                 160

 aaa caa cca gaa cat gat ctg ccc gtt act gaa aac ttg ggt ctg gat      528
 Lys Gln Pro Glu His Asp Leu Pro Val Thr Glu Asn Leu Gly Leu Asp
                 165                 170                 175

 caa tat ata ata aaa cgc ttt gat gga aag gga aat tct tgc ttt aaa      576
 Gln Tyr Ile Ile Lys Arg Phe Asp Gly Lys Gly Asn Ser Cys Phe Lys
             180                 185                 190

 aac act gta aca gat gcc aag aga ata aaa gta ttt cct tga              618
 Asn Thr Val Thr Asp Ala Lys Arg Ile Lys Val Phe Pro 
         195                 200                 205





      <210> 557
      <211> 681
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (1)..(681)

      <400> 557
  atg gcc atg tgg cta tat cca gtg gca gtt ggc agc cta gag gga gga      48
  Met Ala Met Trp Leu Tyr Pro Val Ala Val Gly Ser Leu Glu Gly Gly
    1               5                  10                  15

 gta gag aac gtg gga gga cca att tca tcc aag gtt gga tgc agg ttg       96
 Val Glu Asn Val Gly Gly Pro Ile Ser Ser Lys Val Gly Cys Arg Leu
              20                  25                  30

 gca agg tac tct gta cgt gtg tca cct cag atg gcg aac cgg att gtg      144
 Ala Arg Tyr Ser Val Arg Val Ser Pro Gln Met Ala Asn Arg Ile Val
          35                  40                  45

 gat tct gca agg agc atc ctc aac aag ttc ata cct gat atc tat att      192
 Asp Ser Ala Arg Ser Ile Leu Asn Lys Phe Ile Pro Asp Ile Tyr Ile
      50                  55                  60

 tac aca gat cac atg aaa gga gtc aac tct ggg aag tct ccg ggc ttt      240
 Tyr Thr Asp His Met Lys Gly Val Asn Ser Gly Lys Ser Pro Gly Phe
  65                  70                  75                  80

 ggg ttg tca ctg gtt gct gag acc acc agt ggc acc ttc ctc agt gct      288
 Gly Leu Ser Leu Val Ala Glu Thr Thr Ser Gly Thr Phe Leu Ser Ala
                  85                  90                  95

 gaa ctg gcc tcc aac ccc cag ggc cag gga gca gca gta ctt cca gag      336
 Glu Leu Ala Ser Asn Pro Gln Gly Gln Gly Ala Ala Val Leu Pro Glu
             100                 105                 110

 gac ctt ggc agg aac tgt gcc cgg ctg ctg ctg gag gaa atc tac agg      384
 Asp Leu Gly Arg Asn Cys Ala Arg Leu Leu Leu Glu Glu Ile Tyr Arg
         115                 120                 125

 gtc tgc tgg tgg gac aca gct gag acc aat ttg ccc tct cag ttg cca      432
 Val Cys Trp Trp Asp Thr Ala Glu Thr Asn Leu Pro Ser Gln Leu Pro
     130                 135                 140

 cag tct ttc tct gtt gat cct ttc att gca acg ggc aca tat gca tgc      480
 Gln Ser Phe Ser Val Asp Pro Phe Ile Ala Thr Gly Thr Tyr Ala Cys
 145                 150                 155                 160

 aca cac ttt tac tgt ttc ctc aaa ata gtg agt ctt act ctg ttg ccc      528
 Thr His Phe Tyr Cys Phe Leu Lys Ile Val Ser Leu Thr Leu Leu Pro
                 165                 170                 175

 agg ata gaa ttt ttg cgg cat ttg aag agc ttt ttc cag att atg ttt      576
 Arg Ile Glu Phe Leu Arg His Leu Lys Ser Phe Phe Gln Ile Met Phe
             180                 185                 190

 aaa att gaa acc aag cca tgt ggt gaa gaa ctc aag ggt ggg gat aaa      624
 Lys Ile Glu Thr Lys Pro Cys Gly Glu Glu Leu Lys Gly Gly Asp Lys
         195                 200                 205

 gtg ctg atg acc tgt gtt ggc att ggt ttc tcc aac ctt agc aag acc      672
 Val Leu Met Thr Cys Val Gly Ile Gly Phe Ser Asn Leu Ser Lys Thr
     210                 215                 220

 ctc aag tga                                                          681
 Leu Lys 
 225





      <210> 558
      <211> 378
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (1)..(378)

      <400> 558
  atg aat ggg cat atc tcc tgg cag gtc cct gtg tgg gaa gaa atg ctg      48
  Met Asn Gly His Ile Ser Trp Gln Val Pro Val Trp Glu Glu Met Leu
    1               5                  10                  15

 tca gac tac agg aca gtt ctt ttt act ctg acg tct gtg gtt gta ctt       96
 Ser Asp Tyr Arg Thr Val Leu Phe Thr Leu Thr Ser Val Val Val Leu
              20                  25                  30

 gtg att aca acg gac tgg atc agc tgg gac aag ctg aat cgg gga ttt      144
 Val Ile Thr Thr Asp Trp Ile Ser Trp Asp Lys Leu Asn Arg Gly Phe
          35                  40                  45

 ttg ccc agt gat gaa gtt tcc aga gca ttc ctt gct tct ttt atc ttg      192
 Leu Pro Ser Asp Glu Val Ser Arg Ala Phe Leu Ala Ser Phe Ile Leu
      50                  55                  60

 gtc ttt gac ctt ctt att gtg atg cag cag tgg cca cgt ggc aca gaa      240
 Val Phe Asp Leu Leu Ile Val Met Gln Gln Trp Pro Arg Gly Thr Glu
  65                  70                  75                  80

 tct atg tgc tta ggg gag gga gga gag cac agt gac tat ggg act ttg      288
 Ser Met Cys Leu Gly Glu Gly Gly Glu His Ser Asp Tyr Gly Thr Leu
                  85                  90                  95

 cat tgg aac tta gtg ctg cct gtc ata gca gaa tgc aac aca ggg caa      336
 His Trp Asn Leu Val Leu Pro Val Ile Ala Glu Cys Asn Thr Gly Gln
             100                 105                 110

 aat tca gct ggc aca cat aga gag cat cta gac cag ccc tag              378
 Asn Ser Ala Gly Thr His Arg Glu His Leu Asp Gln Pro 
         115                 120                 125





      <210> 559
      <211> 1617
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (1)..(1617)

      <400> 559
  atg cct tca aac aaa cag cag cct cca ctg cct ctt tca gtc cta ggc      48
  Met Pro Ser Asn Lys Gln Gln Pro Pro Leu Pro Leu Ser Val Leu Gly
    1               5                  10                  15

 ctg aat att ctt gaa att ctt ggc ctc gct gct acc tcc tgc gcc gtg       96
 Leu Asn Ile Leu Glu Ile Leu Gly Leu Ala Ala Thr Ser Cys Ala Val
              20                  25                  30

 gtt cca cgg agc gtc act ccc tct gtg act tct ggg tca gcc gat ggg      144
 Val Pro Arg Ser Val Thr Pro Ser Val Thr Ser Gly Ser Ala Asp Gly
          35                  40                  45

 gat gga cag agt ctg gca gtg ggt aca gga acc ctc gcc aca ccc acg      192
 Asp Gly Gln Ser Leu Ala Val Gly Thr Gly Thr Leu Ala Thr Pro Thr
      50                  55                  60

 ggg ggc cag gac cac act gta gca ggc ttc gag cca cct gct ctg cct      240
 Gly Gly Gln Asp His Thr Val Ala Gly Phe Glu Pro Pro Ala Leu Pro
  65                  70                  75                  80

 gcc cca gag acc tca cgg aag aag aat gcc aaa gct gtg ctc agc ccc      288
 Ala Pro Glu Thr Ser Arg Lys Lys Asn Ala Lys Ala Val Leu Ser Pro
                  85                  90                  95

 cag ggc acg acc gag tct cca ggt ctg aga agg aaa gac ggg act cag      336
 Gln Gly Thr Thr Glu Ser Pro Gly Leu Arg Arg Lys Asp Gly Thr Gln
             100                 105                 110

 agg gct ttg gtg tca ggg gcc tac ctt ccc atc ctg tac ccc gca cct      384
 Arg Ala Leu Val Ser Gly Ala Tyr Leu Pro Ile Leu Tyr Pro Ala Pro
         115                 120                 125

 gaa gaa tcc cag cct cca gca cct gcc ttt ccc cgc act cca ggg gat      432
 Glu Glu Ser Gln Pro Pro Ala Pro Ala Phe Pro Arg Thr Pro Gly Asp
     130                 135                 140

 tct gat cac agg cag gtg tgg ggc cac agc cct ggc ctc gtc tcc ggg      480
 Ser Asp His Arg Gln Val Trp Gly His Ser Pro Gly Leu Val Ser Gly
 145                 150                 155                 160

 gtc tgc agg ctc agt gct ccc tgc agc tct tcc cag gtg gtg gga caa      528
 Val Cys Arg Leu Ser Ala Pro Cys Ser Ser Ser Gln Val Val Gly Gln
                 165                 170                 175

 ggc tcg tcg ccg cgg ccc ccc gag ccc gac cgc cgc cgc cac cac cac      576
 Gly Ser Ser Pro Arg Pro Pro Glu Pro Asp Arg Arg Arg His His His
             180                 185                 190

 cag cgc ccg ggc ggg cct cgc gcg cct cgg gcg cgg ctc cgc agt gag      624
 Gln Arg Pro Gly Gly Pro Arg Ala Pro Arg Ala Arg Leu Arg Ser Glu
         195                 200                 205

 ccc acc aag aag gaa gcg gag gct ggc ccc aga tct caa agg gag tgg      672
 Pro Thr Lys Lys Glu Ala Glu Ala Gly Pro Arg Ser Gln Arg Glu Trp
     210                 215                 220

 aca ggg ctc tcc aca ctc cca cat aaa ttc acc ccc aac aca aca ggc      720
 Thr Gly Leu Ser Thr Leu Pro His Lys Phe Thr Pro Asn Thr Thr Gly
 225                 230                 235                 240

 cac act gtg gaa ttg ggg cca cgt agt ggg ggt gcc ctg gtg gta cct      768
 His Thr Val Glu Leu Gly Pro Arg Ser Gly Gly Ala Leu Val Val Pro
                 245                 250                 255

 agt ggc aat cac act gat gac gat gat gag gat gat gat ggt aaa ggt      816
 Ser Gly Asn His Thr Asp Asp Asp Asp Glu Asp Asp Asp Gly Lys Gly
             260                 265                 270

 ggc agc aac aat gat gac agt gac aag gat gac aac agt aac acc tcc      864
 Gly Ser Asn Asn Asp Asp Ser Asp Lys Asp Asp Asn Ser Asn Thr Ser
         275                 280                 285

 cat cag gcc cag tgc tct gaa tca aat ttc aac atg agg ttt gga agg      912
 His Gln Ala Gln Cys Ser Glu Ser Asn Phe Asn Met Arg Phe Gly Arg
     290                 295                 300

 gac aaa tat cca aac tat agc aat aag aat gat gag aac aat gat gat      960
 Asp Lys Tyr Pro Asn Tyr Ser Asn Lys Asn Asp Glu Asn Asn Asp Asp
 305                 310                 315                 320

 gat gaa gat gat ggt gac aac tct gtc cca ggc cct gtc ctg gag gct     1008
 Asp Glu Asp Asp Gly Asp Asn Ser Val Pro Gly Pro Val Leu Glu Ala
                 325                 330                 335

 ggt ggc tca atg cct gcc tgc aga ggt gcc gac atg ggg ctt aag atg     1056
 Gly Gly Ser Met Pro Ala Cys Arg Gly Ala Asp Met Gly Leu Lys Met
             340                 345                 350

 tcc tgc ctg aaa ggg gtc ttt gtc tac tct gct gac ctc cac acc caa     1104
 Ser Cys Leu Lys Gly Val Phe Val Tyr Ser Ala Asp Leu His Thr Gln
         355                 360                 365

 gct gcg aac agg agc caa cgc aca gtc gct gtt cca tgg tgc tgg ttc     1152
 Ala Ala Asn Arg Ser Gln Arg Thr Val Ala Val Pro Trp Cys Trp Phe
     370                 375                 380

 cct tcc agt gcg gga cag agc cca gag gag agt gtg tcc cgg gca act     1200
 Pro Ser Ser Ala Gly Gln Ser Pro Glu Glu Ser Val Ser Arg Ala Thr
 385                 390                 395                 400

 cca cac aaa cat gta ctg agt acc tgc tgc atg cca ggc agc aca ctc     1248
 Pro His Lys His Val Leu Ser Thr Cys Cys Met Pro Gly Ser Thr Leu
                 405                 410                 415

 agc cct cgg gat gca gca gtg agc agc aca gag ctc ctg tcc atg ggg     1296
 Ser Pro Arg Asp Ala Ala Val Ser Ser Thr Glu Leu Leu Ser Met Gly
             420                 425                 430

 gag aga cgg aaa tgt gga atg gtg tgt gtg aac aaa cac aca ccc agc     1344
 Glu Arg Arg Lys Cys Gly Met Val Cys Val Asn Lys His Thr Pro Ser
         435                 440                 445

 agg ctg gat ttc gtg gtg agt gct gtg aag gga att gag caa gga ggt     1392
 Arg Leu Asp Phe Val Val Ser Ala Val Lys Gly Ile Glu Gln Gly Gly
     450                 455                 460

 gca gtc gag ggg atg agg caa ggc ttt caa atg tgt gtc agc agc agc     1440
 Ala Val Glu Gly Met Arg Gln Gly Phe Gln Met Cys Val Ser Ser Ser
 465                 470                 475                 480

 agc agc agc cac gac gag gcc ccc gtc ctg aac gac aag cac ctg gac     1488
 Ser Ser Ser His Asp Glu Ala Pro Val Leu Asn Asp Lys His Leu Asp
                 485                 490                 495

 gtg ccc gac atc atc atc acg ccc ccc acc ccc acg ggc atg atg ctg     1536
 Val Pro Asp Ile Ile Ile Thr Pro Pro Thr Pro Thr Gly Met Met Leu
             500                 505                 510

 ccg agg gac ttg ggg agc aca gtc tgg ctg gat gag aca ggg tcg tgc     1584
 Pro Arg Asp Leu Gly Ser Thr Val Trp Leu Asp Glu Thr Gly Ser Cys
         515                 520                 525

 cca gat gat gga gaa atc gac cca gaa gcc tga                         1617
 Pro Asp Asp Gly Glu Ile Asp Pro Glu Ala 
     530                 535





      <210> 560
      <211> 477
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (1)..(477)

      <400> 560
  atg ggg ttt cac cgt gtt gcc cag gct ggt ctc aaa ctc ctg acc tca      48
  Met Gly Phe His Arg Val Ala Gln Ala Gly Leu Lys Leu Leu Thr Ser
    1               5                  10                  15

 ggg atg cag tat tgc ttc tgg ttt act atc ttg gtg aag agg gaa ctt       96
 Gly Met Gln Tyr Cys Phe Trp Phe Thr Ile Leu Val Lys Arg Glu Leu
              20                  25                  30

 tct atg gac ttc tac tta gtc cct cct acc ata atg gcc ctt acc tat      144
 Ser Met Asp Phe Tyr Leu Val Pro Pro Thr Ile Met Ala Leu Thr Tyr
          35                  40                  45

 ggg tca gag aaa gaa ctt ggg gat tct gag agt gac aag tat atc aat      192
 Gly Ser Glu Lys Glu Leu Gly Asp Ser Glu Ser Asp Lys Tyr Ile Asn
      50                  55                  60

 tcc aaa tat aca tcc aag agg tca agt gct gca gaa cac ttt cat atc      240
 Ser Lys Tyr Thr Ser Lys Arg Ser Ser Ala Ala Glu His Phe His Ile
  65                  70                  75                  80

 aga tgc cac ttc cag tgg gac ttc ctg cca cgg tgc cag gtc ccc gga      288
 Arg Cys His Phe Gln Trp Asp Phe Leu Pro Arg Cys Gln Val Pro Gly
                  85                  90                  95

 gac cct gct atg gtg cgt gcg ggc gcc gtg ggg gct cat ctc ccc gcg      336
 Asp Pro Ala Met Val Arg Ala Gly Ala Val Gly Ala His Leu Pro Ala
             100                 105                 110

 tcc ggc ttg gat atc ttc ggg gac ctg aag aag atg aac aag cgc cag      384
 Ser Gly Leu Asp Ile Phe Gly Asp Leu Lys Lys Met Asn Lys Arg Gln
         115                 120                 125

 gtg acg gag gag ggt ggt gag cgc gcc gtg gcc ggg acc gcc tgt gct      432
 Val Thr Glu Glu Gly Gly Glu Arg Ala Val Ala Gly Thr Ala Cys Ala
     130                 135                 140

 agc ggg gag tcg ggg ctt ccc agt cag ggc tcc ggc tcc cag tga          477
 Ser Gly Glu Ser Gly Leu Pro Ser Gln Gly Ser Gly Ser Gln 
 145                 150                 155





      <210> 561
      <211> 1290
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (1164)..(1290)

      <400> 561
 atgaaattga cacaagaaca acaacaacaa atacaaaaca taaataaagc aaaaagttgg     60

 ttatttgaaa agataaataa aatcgataga ccattagcaa gattaaccaa gaaaagaaga    120

 gagaaaatcc aaataacctc actaagaaat gaaacagggg atattacaac tgacaccact    180

 gaaatattaa aggttattca agggtactat gaacaccttt tggcacataa actagaaaac    240

 ctagaagagt tggataaact gctggaaaaa tacaaccctc ctaacttaaa tcaggaagaa    300

 ttagataccc caagcagacc aataaatcaa gcagcaagat tgaaatgtcc ccagaacctt    360

 aatgaccagg tggaacgaac caacaaggtc atactgaaat tgtgcaccag tgccctaatg    420

 accaagagaa aatacatttc attcaattca aagcctagta agctccaggg gctggcagct    480

 ggcacagagt acgaggctgc actccttgac ctttctatgc tgcacacagt cctgtgccca    540

 tcctgtcctc agatctgctg ggaccatgac caacctgcca agagcatggg aattgacttg    600

 ctgctgctgc caccattagc actgacgcca aaggaaccag cgctgctgtc accctccatg    660

 cacctgccca ccctccaagg ctcctaccac ttggcctcca cagcaccaaa tagtgcccca    720

 tcaaacccgc cccccacccg gaccacaagc agcacagccc cagatagcgc ccccaatctg    780

 ctcctgtcac aggcagtgaa cgcccgggtg tacagtcacc atggctgctg tcttggatca    840

 gagttgagtg cctgtggtat ttctaggctc aggatgaaag cttcccgtgg ctctaccatt    900

 cagggatctc gaggtggcag ccccattccc acagctcctg taaggagtgc ctcttcccag    960

 ccgccccatc tgggaaatga ggagcacctc ttgcctggtt gccccatctg ggaagtgagg   1020

 agcgcctctg cccagccgcc ccatctggga agtaaggagc acctctgcct ggccgttgtg   1080

 caatcttcca agtgtgaagt gacagccttt ctgcaggtgt acccaacagc ttcgaagaga   1140

 cagccaccat cgggaacgga cca    tga tga tga tgg cag ttt tgt caa aaa    1190
                              Met Val Arg Ser Arg Trp Trp Leu Ser
                                1               5

 gaa aag agg gaa atg tgg gga aaa gga aga gag atc aga ttg tta ctg     1238
 Leu Arg Ser Cys Trp Val His Leu Gln Lys Gly Cys His Phe Thr Leu
  10                  15                  20                  25

 tgt ctg tgt aga aag aag tag aca tag gag act cca ttt cct tct gta     1286
 Gly Arg Leu His Asn Gly Gln Ala Glu Val Leu Leu Thr Ser Gln Met
                  30                  35                  40

 cta a                                                               1290
 Gly Arg Leu Gly Arg Gly Ala Pro His Phe Pro Asp Gly Ala Thr Arg 
              45                  50                  55





      <210> 562
      <211> 396
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (1)..(396)

      <400> 562
  atg agg ccg cgc tcg ggc ggg cgc cca ggg gcc acg ggc cgc cgc cgc      48
  Met Arg Pro Arg Ser Gly Gly Arg Pro Gly Ala Thr Gly Arg Arg Arg
    1               5                  10                  15

 cgc cgc ctg cgc cgc cgc ccc cgc ggc ctc cgg tgc agc cgc ctg ccg       96
 Arg Arg Leu Arg Arg Arg Pro Arg Gly Leu Arg Cys Ser Arg Leu Pro
              20                  25                  30

 ccg ccg ccg ccg ctg ccg ctg ctg ctc ggg ctg ctg ctg gcg gcc gcg      144
 Pro Pro Pro Pro Leu Pro Leu Leu Leu Gly Leu Leu Leu Ala Ala Ala
          35                  40                  45

 ggg ccc ggc gcg gcg cgg gcc aag gag acg gcg ttc gtg gag gtg gtg      192
 Gly Pro Gly Ala Ala Arg Ala Lys Glu Thr Ala Phe Val Glu Val Val
      50                  55                  60

 ctg ttc gag tcg agc cca agc ggc gat tac acc acc tac acc acc ggc      240
 Leu Phe Glu Ser Ser Pro Ser Gly Asp Tyr Thr Thr Tyr Thr Thr Gly
  65                  70                  75                  80

 ctc acg ggc cgc ttc tcg cgg gcc ggg gcc acg ctc agc gcc gag ggc      288
 Leu Thr Gly Arg Phe Ser Arg Ala Gly Ala Thr Leu Ser Ala Glu Gly
                  85                  90                  95

 gag atc gtg cag gct tgg agc cct tct gtt acc ccc ggc tgt agc ctg      336
 Glu Ile Val Gln Ala Trp Ser Pro Ser Val Thr Pro Gly Cys Ser Leu
             100                 105                 110

 gct gag tgt gac agg gga cac cag atg cag ggc atg ctt tat gat cag      384
 Ala Glu Cys Asp Arg Gly His Gln Met Gln Gly Met Leu Tyr Asp Gln
         115                 120                 125

 atg tat aat tga                                                      396
 Met Tyr Asn 
     130





      <210> 563
      <211> 906
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (1)..(906)

      <400> 563
  atg agc att ctg agc aga cgc tac gct ctt tgt cag cta gca gct tgt      48
  Met Ser Ile Leu Ser Arg Arg Tyr Ala Leu Cys Gln Leu Ala Ala Cys
    1               5                  10                  15

 gtg ttt ccc ttt cac atc tgg acc tgc atc tgc tca cat ttc acg tcc       96
 Val Phe Pro Phe His Ile Trp Thr Cys Ile Cys Ser His Phe Thr Ser
              20                  25                  30

 ccc gtg aat gct cgg ctt act gaa tat gtc aaa ctg cct agc aca cag      144
 Pro Val Asn Ala Arg Leu Thr Glu Tyr Val Lys Leu Pro Ser Thr Gln
          35                  40                  45

 gct ggc aac aga gca aaa ctc ctg gca tcc aaa tcg ccc tgg gag agc      192
 Ala Gly Asn Arg Ala Lys Leu Leu Ala Ser Lys Ser Pro Trp Glu Ser
      50                  55                  60

 cag cac agc ccg ttc ttc gcc gag cag ctg acc gca ttc cag gtg tgg      240
 Gln His Ser Pro Phe Phe Ala Glu Gln Leu Thr Ala Phe Gln Val Trp
  65                  70                  75                  80

 ctc acc atg ggc gtg gag aac cga aac cca ccc gaa cag ctg ccc atc      288
 Leu Thr Met Gly Val Glu Asn Arg Asn Pro Pro Glu Gln Leu Pro Ile
                  85                  90                  95

 gtc ctg cag gcc ttg tct gtc ggc atc ttc ccc tac gtg ctg aag ctg      336
 Val Leu Gln Ala Leu Ser Val Gly Ile Phe Pro Tyr Val Leu Lys Leu
             100                 105                 110

 ctc cag agc tcg gcc cga gag ctg cgg cca ctt ctc gtt ttc atc tgg      384
 Leu Gln Ser Ser Ala Arg Glu Leu Arg Pro Leu Leu Val Phe Ile Trp
         115                 120                 125

 gcc aag atc ctc gca gtg gac agc gga aat gga agg tct agc aaa gtc      432
 Ala Lys Ile Leu Ala Val Asp Ser Gly Asn Gly Arg Ser Ser Lys Val
     130                 135                 140

 aca gag caa gta cag gag agt gcc aag aac acc ttg gag agg cca tgg      480
 Thr Glu Gln Val Gln Glu Ser Ala Lys Asn Thr Leu Glu Arg Pro Trp
 145                 150                 155                 160

 ctt gga gcc ggg gaa gac cac cct ttc ctt ttc tgt gtg gca gcc gct      528
 Leu Gly Ala Gly Glu Asp His Pro Phe Leu Phe Cys Val Ala Ala Ala
                 165                 170                 175

 gct gat tca agt cca gcc cag gcc atc agg tcc cca act gtg ctg ccc      576
 Ala Asp Ser Ser Pro Ala Gln Ala Ile Arg Ser Pro Thr Val Leu Pro
             180                 185                 190

 acg gac ccc tgg gcc cct gct cag ccc ttc tgc tcc ctg cac cca gcc      624
 Thr Asp Pro Trp Ala Pro Ala Gln Pro Phe Cys Ser Leu His Pro Ala
         195                 200                 205

 ctg acc ata gcc tcc cca cac ccc aag tcc tca cgt act act ttg gtg      672
 Leu Thr Ile Ala Ser Pro His Pro Lys Ser Ser Arg Thr Thr Leu Val
     210                 215                 220

 tca cag ctg aag tca ggg ggc agt ggg gag gct gct gcc gaa gcg gac      720
 Ser Gln Leu Lys Ser Gly Gly Ser Gly Glu Ala Ala Ala Glu Ala Asp
 225                 230                 235                 240

 gat ttc cta cag atg gaa aag gtg aga gtg acg gca ggt ttc ttc tta      768
 Asp Phe Leu Gln Met Glu Lys Val Arg Val Thr Ala Gly Phe Phe Leu
                 245                 250                 255

 cag att tcc tac aga tgg aaa agt gtg gag act gaa cgc cac aat gag      816
 Gln Ile Ser Tyr Arg Trp Lys Ser Val Glu Thr Glu Arg His Asn Glu
             260                 265                 270

 aag gca gag gcc acc agg ttg aag agc aag aaa aaa cca tac cat ggc      864
 Lys Ala Glu Ala Thr Arg Leu Lys Ser Lys Lys Lys Pro Tyr His Gly
         275                 280                 285

 tac aag caa tgt act ttt ggc ata aag aca cga gta gat tga              906
 Tyr Lys Gln Cys Thr Phe Gly Ile Lys Thr Arg Val Asp 
     290                 295                 300





      <210> 564
      <211> 1029
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (1)..(1029)

      <400> 564
  atg agt ggt ggt atg tgg ata gct att tta gcc tgg act aag gtg gtc      48
  Met Ser Gly Gly Met Trp Ile Ala Ile Leu Ala Trp Thr Lys Val Val
    1               5                  10                  15

 aag gac agg aac ttc tcc ttt tgc ata tta ttt gaa acc aga agt atc       96
 Lys Asp Arg Asn Phe Ser Phe Cys Ile Leu Phe Glu Thr Arg Ser Ile
              20                  25                  30

 agt tac att gat ggt ttc tat gaa aat ggc cag aaa atc att gag aat      144
 Ser Tyr Ile Asp Gly Phe Tyr Glu Asn Gly Gln Lys Ile Ile Glu Asn
          35                  40                  45

 tgg aag gaa acc aac aat tca att cag aaa aac atg ctg ata ttt ggg      192
 Trp Lys Glu Thr Asn Asn Ser Ile Gln Lys Asn Met Leu Ile Phe Gly
      50                  55                  60

 aac ggt aaa ttg ttc aag gcc aaa tat gta aga cat gac ttc gtc ctc      240
 Asn Gly Lys Leu Phe Lys Ala Lys Tyr Val Arg His Asp Phe Val Leu
  65                  70                  75                  80

 ttt gcc ttc cac tat gac tgt aag ttt cct gag gcc tcc cca gcc atg      288
 Phe Ala Phe His Tyr Asp Cys Lys Phe Pro Glu Ala Ser Pro Ala Met
                  85                  90                  95

 ctt cct aat cct ggc gga atc tgc tgc ctt agt cac atc cct cta cag      336
 Leu Pro Asn Pro Gly Gly Ile Cys Cys Leu Ser His Ile Pro Leu Gln
             100                 105                 110

 act gat cct cca gag gga ctc ggc cga aag ccc tct ctg gcc tgg gcc      384
 Thr Asp Pro Pro Glu Gly Leu Gly Arg Lys Pro Ser Leu Ala Trp Ala
         115                 120                 125

 aga tgc tct gtc tat gtt gtc aat gag gaa ctg att aac tgg atc aga      432
 Arg Cys Ser Val Tyr Val Val Asn Glu Glu Leu Ile Asn Trp Ile Arg
     130                 135                 140

 gga ggc ccc tca aag ctc tca ggc ctt cca gag gac tct gtt ggt ttg      480
 Gly Gly Pro Ser Lys Leu Ser Gly Leu Pro Glu Asp Ser Val Gly Leu
 145                 150                 155                 160

 ggg tac gta gaa tgg gac ctc aca atg atg tct gtc ctc ctt ggt atc      528
 Gly Tyr Val Glu Trp Asp Leu Thr Met Met Ser Val Leu Leu Gly Ile
                 165                 170                 175

 ctg tct cca gtt agt caa cgt ggc cac cag ttc act gac tgg att aag      576
 Leu Ser Pro Val Ser Gln Arg Gly His Gln Phe Thr Asp Trp Ile Lys
             180                 185                 190

 aaa atg tgg cac ata tac acc atg gaa tac tat gca gcc ata aaa aag      624
 Lys Met Trp His Ile Tyr Thr Met Glu Tyr Tyr Ala Ala Ile Lys Lys
         195                 200                 205

 gat gag ttc atg tcc ttt gta ggg aca tgg atg aag ctg gaa acc atc      672
 Asp Glu Phe Met Ser Phe Val Gly Thr Trp Met Lys Leu Glu Thr Ile
     210                 215                 220

 att ctc agc aaa cta tcg caa gga cag aaa acc aaa cac cgc atg ttc      720
 Ile Leu Ser Lys Leu Ser Gln Gly Gln Lys Thr Lys His Arg Met Phe
 225                 230                 235                 240

 tca ctc ata gac tgg att aag aaa atg tgg cac ata tac acc atg gaa      768
 Ser Leu Ile Asp Trp Ile Lys Lys Met Trp His Ile Tyr Thr Met Glu
                 245                 250                 255

 tac tat gca gcc ata aaa aag gat gag ttc atg ccg ttt gta ggg aca      816
 Tyr Tyr Ala Ala Ile Lys Lys Asp Glu Phe Met Pro Phe Val Gly Thr
             260                 265                 270

 tgg atg aag ctg gaa acc atc att ctc agc aaa cta tca caa gga cag      864
 Trp Met Lys Leu Glu Thr Ile Ile Leu Ser Lys Leu Ser Gln Gly Gln
         275                 280                 285

 aaa acc aaa cac cgc atg ttc tca ctc ata gaa gaa gtc aaa gaa acg      912
 Lys Thr Lys His Arg Met Phe Ser Leu Ile Glu Glu Val Lys Glu Thr
     290                 295                 300

 gta tac act tca gct cct ttt gac aaa cat tta ctg acc acc gcc aag      960
 Val Tyr Thr Ser Ala Pro Phe Asp Lys His Leu Leu Thr Thr Ala Lys
 305                 310                 315                 320

 atg cca ggc aca tgg aca ttc cgc atg cct gca ttc aag gag acg cca     1008
 Met Pro Gly Thr Trp Thr Phe Arg Met Pro Ala Phe Lys Glu Thr Pro
                 325                 330                 335

 gac tca gtt gag tgg ata tga                                         1029
 Asp Ser Val Glu Trp Ile 
             340





      <210> 565
      <211> 1560
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (1)..(1560)

      <400> 565
  atg att ata tca cat ttt cca aaa tgt gtg gca gtt ttt gcc ctc ctt      48
  Met Ile Ile Ser His Phe Pro Lys Cys Val Ala Val Phe Ala Leu Leu
    1               5                  10                  15

 gct ctg agt gtt ggt gca ctg gac act ttt att gct gca gta tat gag       96
 Ala Leu Ser Val Gly Ala Leu Asp Thr Phe Ile Ala Ala Val Tyr Glu
              20                  25                  30

 cat gcg gtg ata tta cca aac aga aca gaa aca cct gtt tca aaa gaa      144
 His Ala Val Ile Leu Pro Asn Arg Thr Glu Thr Pro Val Ser Lys Glu
          35                  40                  45

 gaa gct ttg ctc ctg atg aac aag aac ata gat gtt ttg gag aaa gca      192
 Glu Ala Leu Leu Leu Met Asn Lys Asn Ile Asp Val Leu Glu Lys Ala
      50                  55                  60

 gtt aag ctg gca gcg aag cag gta tta ccc ttt tat act tgt aaa gga      240
 Val Lys Leu Ala Ala Lys Gln Val Leu Pro Phe Tyr Thr Cys Lys Gly
  65                  70                  75                  80

 gac ttg cag ttt ggt caa aga gta ttt gga att cat gac aaa ctt ttt      288
 Asp Leu Gln Phe Gly Gln Arg Val Phe Gly Ile His Asp Lys Leu Phe
                  85                  90                  95

 tgc ccc act tgt ttc gag cag ggt gca cat atc att gtg acc cca gaa      336
 Cys Pro Thr Cys Phe Glu Gln Gly Ala His Ile Ile Val Thr Pro Glu
             100                 105                 110

 gat gga atc tat ggt tgg atc ttc acc agg gag agc att tac ccc tat      384
 Asp Gly Ile Tyr Gly Trp Ile Phe Thr Arg Glu Ser Ile Tyr Pro Tyr
         115                 120                 125

 cta gag gat ata cca gac cct gga gtg aac tgg att cca tgt aga gac      432
 Leu Glu Asp Ile Pro Asp Pro Gly Val Asn Trp Ile Pro Cys Arg Asp
     130                 135                 140

 ccc tgg aga ttc ggc aac aca cca gtg caa caa aga ctc agc tgc ctg      480
 Pro Trp Arg Phe Gly Asn Thr Pro Val Gln Gln Arg Leu Ser Cys Leu
 145                 150                 155                 160

 gcc aag gac aac tct atc tat gtc gtg gct aat att ggg gac aag aag      528
 Ala Lys Asp Asn Ser Ile Tyr Val Val Ala Asn Ile Gly Asp Lys Lys
                 165                 170                 175

 cca tgc aat gcc agt gac tct cag tgt ccc cct gat ggc cgt tac caa      576
 Pro Cys Asn Ala Ser Asp Ser Gln Cys Pro Pro Asp Gly Arg Tyr Gln
             180                 185                 190

 tac aac act gat gtg gtg ttt gat tct cag gga aaa ctg ttg gca cgc      624
 Tyr Asn Thr Asp Val Val Phe Asp Ser Gln Gly Lys Leu Leu Ala Arg
         195                 200                 205

 tac cat aag tac aat ctt ttt gca cct gaa att cag ttt gat ttc ccc      672
 Tyr His Lys Tyr Asn Leu Phe Ala Pro Glu Ile Gln Phe Asp Phe Pro
     210                 215                 220

 aag gat tca gaa ctt gtg act ttt gac act ccc ttt ggg aag ttt ggc      720
 Lys Asp Ser Glu Leu Val Thr Phe Asp Thr Pro Phe Gly Lys Phe Gly
 225                 230                 235                 240

 att ttt act tgc ttt gac att ttt tct cat gac cca gct gtg gtg gtg      768
 Ile Phe Thr Cys Phe Asp Ile Phe Ser His Asp Pro Ala Val Val Val
                 245                 250                 255

 gtg gat gag ttt caa ttg aca gca ttc tct acc cca cag cat gca tgg      816
 Val Asp Glu Phe Gln Leu Thr Ala Phe Ser Thr Pro Gln His Ala Trp
             260                 265                 270

 gcc aag gcc atg gga gtc aat cta ctt gct gca aat acc cac aac acc      864
 Ala Lys Ala Met Gly Val Asn Leu Leu Ala Ala Asn Thr His Asn Thr
         275                 280                 285

 agc atg cac atg aca ggg agt gga atc tac gcc cca gaa gca gtc aag      912
 Ser Met His Met Thr Gly Ser Gly Ile Tyr Ala Pro Glu Ala Val Lys
     290                 295                 300

 gtg tac cac tat gac atg gaa aca gag agt ggt cag ctg ttg cta tca      960
 Val Tyr His Tyr Asp Met Glu Thr Glu Ser Gly Gln Leu Leu Leu Ser
 305                 310                 315                 320

 gaa ctg aag tct cgg ccc cgc cgt gag ccc acc tac cct gca gct gtt     1008
 Glu Leu Lys Ser Arg Pro Arg Arg Glu Pro Thr Tyr Pro Ala Ala Val
                 325                 330                 335

 gac tgg cat gcg tat gcc agc agt gtc aag cca ttt tcc tct gaa cag     1056
 Asp Trp His Ala Tyr Ala Ser Ser Val Lys Pro Phe Ser Ser Glu Gln
             340                 345                 350

 tca gat ttt ctg ggg atg att tat ttt gat gag ttt acc ttc acc aag     1104
 Ser Asp Phe Leu Gly Met Ile Tyr Phe Asp Glu Phe Thr Phe Thr Lys
         355                 360                 365

 ctt aag aga aat aca gga aat tac aca gct tgc cag aaa gat ctg tgt     1152
 Leu Lys Arg Asn Thr Gly Asn Tyr Thr Ala Cys Gln Lys Asp Leu Cys
     370                 375                 380

 tgt cac tta act tac aag atg tct gag aag cga aca gac gag atc tat     1200
 Cys His Leu Thr Tyr Lys Met Ser Glu Lys Arg Thr Asp Glu Ile Tyr
 385                 390                 395                 400

 gcc cta ggt gct ttt gat gga ctg cac aca gta gaa ggc caa tat tac     1248
 Ala Leu Gly Ala Phe Asp Gly Leu His Thr Val Glu Gly Gln Tyr Tyr
                 405                 410                 415

 tta cag ata tgt gca tta ctg aag tgt caa acc act gac ctg gaa acg     1296
 Leu Gln Ile Cys Ala Leu Leu Lys Cys Gln Thr Thr Asp Leu Glu Thr
             420                 425                 430

 tgt gga gaa cct gtg ggg tca gct ttt acc aag ttt gaa gac ttc tcc     1344
 Cys Gly Glu Pro Val Gly Ser Ala Phe Thr Lys Phe Glu Asp Phe Ser
         435                 440                 445

 ctc agt ggc aca ttt gga acg cgt tat gtt ttc cca cag atc att cta     1392
 Leu Ser Gly Thr Phe Gly Thr Arg Tyr Val Phe Pro Gln Ile Ile Leu
     450                 455                 460

 agt ggg agt cag ctt gcc cct gaa aga cat tat gag gcc ttc agg cct     1440
 Ser Gly Ser Gln Leu Ala Pro Glu Arg His Tyr Glu Ala Phe Arg Pro
 465                 470                 475                 480

 gga ctg gaa ttg aca cca tca act ctt cag ctc tca ggc ctt cga atg     1488
 Gly Leu Glu Leu Thr Pro Ser Thr Leu Gln Leu Ser Gly Leu Arg Met
                 485                 490                 495

 aca ccc ctg gct ttc ctg cat ctc cag ctt gca aat ggc aga cca gac     1536
 Thr Pro Leu Ala Phe Leu His Leu Gln Leu Ala Asn Gly Arg Pro Asp
             500                 505                 510

 tgt ggg att tct cag cct tca taa                                     1560
 Cys Gly Ile Ser Gln Pro Ser 
         515





      <210> 566
      <211> 1377
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (1)..(1377)

      <400> 566
  atg gtg gat aag ctt ttt gat gtg ctg ctg gat tcg gtt tgc cag tat      48
  Met Val Asp Lys Leu Phe Asp Val Leu Leu Asp Ser Val Cys Gln Tyr
    1               5                  10                  15

 ttt att gag gat ttt tgc atc aat gtt cac caa gga tat tgg tct aaa       96
 Phe Ile Glu Asp Phe Cys Ile Asn Val His Gln Gly Tyr Trp Ser Lys
              20                  25                  30

 att ctc ttt ttt ggt tgt gtc tct gcc cag ctt tgt aag tta aag ttg      144
 Ile Leu Phe Phe Gly Cys Val Ser Ala Gln Leu Cys Lys Leu Lys Leu
          35                  40                  45

 aaa tcc atc cat tgg tgc ttc ctg ctg ctg aaa tat aaa ctg ttg ttg      192
 Lys Ser Ile His Trp Cys Phe Leu Leu Leu Lys Tyr Lys Leu Leu Leu
      50                  55                  60

 gtt ttc atc cac ctg agg tac aat gct ggg gtc atc ttc ttc tac acc      240
 Val Phe Ile His Leu Arg Tyr Asn Ala Gly Val Ile Phe Phe Tyr Thr
  65                  70                  75                  80

 aaa gta atg ttc aat cag atc aaa tgc ctt ctg acc tat ctt tgt gcc      288
 Lys Val Met Phe Asn Gln Ile Lys Cys Leu Leu Thr Tyr Leu Cys Ala
                  85                  90                  95

 atc tac ctt gtt tgg gcc tac aat ggc ttc tcg aca aaa gaa gaa agg      336
 Ile Tyr Leu Val Trp Ala Tyr Asn Gly Phe Ser Thr Lys Glu Glu Arg
             100                 105                 110

 aag gaa gat aat aca ttt ttt aaa gag gag gac ctg ctg aaa gaa tct      384
 Lys Glu Asp Asn Thr Phe Phe Lys Glu Glu Asp Leu Leu Lys Glu Ser
         115                 120                 125

 gaa ctc acc acg cct tcg cgt ccg caa ggg aaa ggt ccg gct gcc acg      432
 Glu Leu Thr Thr Pro Ser Arg Pro Gln Gly Lys Gly Pro Ala Ala Thr
     130                 135                 140

 ccc ccg cga ccg ctg tcg ccc tgg gga aaa cac gag aaa cac ccg gca      480
 Pro Pro Arg Pro Leu Ser Pro Trp Gly Lys His Glu Lys His Pro Ala
 145                 150                 155                 160

 ccg cca ggt tcc aga gac ctt cgc aaa caa atc aaa cgt cag aaa atc      528
 Pro Pro Gly Ser Arg Asp Leu Arg Lys Gln Ile Lys Arg Gln Lys Ile
                 165                 170                 175

 ttt gaa tcc acc tgt aac ctg tgc ccc gaa cca ctt caa gat gtc cag      576
 Phe Glu Ser Thr Cys Asn Leu Cys Pro Glu Pro Leu Gln Asp Val Gln
             180                 185                 190

 cct ttt aaa atc aaa cca acg tat agc ttc cgt gta ttg att tat gac      624
 Pro Phe Lys Ile Lys Pro Thr Tyr Ser Phe Arg Val Leu Ile Tyr Asp
         195                 200                 205

 gtc gcc tgt aac ctc tgc ctc ctc acc ttt aaa aac tct tac ctg ccc      672
 Val Ala Cys Asn Leu Cys Leu Leu Thr Phe Lys Asn Ser Tyr Leu Pro
     210                 215                 220

 aaa gct ttg acc cag tta gtg cct gct agt ttc gtg tgc ctg gct tgt      720
 Lys Ala Leu Thr Gln Leu Val Pro Ala Ser Phe Val Cys Leu Ala Cys
 225                 230                 235                 240

 gcc ttt ggc gcg gaa cgt ttg gga gac tcg gcc ttg cgg tct tct gac      768
 Ala Phe Gly Ala Glu Arg Leu Gly Asp Ser Ala Leu Arg Ser Ser Asp
                 245                 250                 255

 ctc acc cac cac cta ctt gtc aat acc atg ctt tcc tgt aat att tgt      816
 Leu Thr His His Leu Leu Val Asn Thr Met Leu Ser Cys Asn Ile Cys
             260                 265                 270

 ggt gaa aca gta acc tca gaa cca gac atg aaa gct cac cta att gtt      864
 Gly Glu Thr Val Thr Ser Glu Pro Asp Met Lys Ala His Leu Ile Val
         275                 280                 285

 cac atg gaa agt gaa att ata tgt cca ttt tgc aag ttg tca ggt gtg      912
 His Met Glu Ser Glu Ile Ile Cys Pro Phe Cys Lys Leu Ser Gly Val
     290                 295                 300

 aat tat gat gaa atg tgt ttt cat atc gaa aca gct cat ttt gag cag      960
 Asn Tyr Asp Glu Met Cys Phe His Ile Glu Thr Ala His Phe Glu Gln
 305                 310                 315                 320

 aat aca ctt gaa aga aac ttt gag agg ata aat aca gta caa tat gga     1008
 Asn Thr Leu Glu Arg Asn Phe Glu Arg Ile Asn Thr Val Gln Tyr Gly
                 325                 330                 335

 act tca gat aac aag aaa gac aac acc cta cag tgt gga atg gaa gtt     1056
 Thr Ser Asp Asn Lys Lys Asp Asn Thr Leu Gln Cys Gly Met Glu Val
             340                 345                 350

 aat tca agt att ctt tca ggt tgt gca tct aat cat cca aaa aat tca     1104
 Asn Ser Ser Ile Leu Ser Gly Cys Ala Ser Asn His Pro Lys Asn Ser
         355                 360                 365

 gct caa aac ctg act aaa gat agt act tta aaa cat gaa ggc ttc tat     1152
 Ala Gln Asn Leu Thr Lys Asp Ser Thr Leu Lys His Glu Gly Phe Tyr
     370                 375                 380

 tca gag aac tta act gaa tct aga aaa ttc ctg aaa agt agg gaa aaa     1200
 Ser Glu Asn Leu Thr Glu Ser Arg Lys Phe Leu Lys Ser Arg Glu Lys
 385                 390                 395                 400

 cag tcc agc ctg acc gaa ata aaa gga tct gtt tat gaa aca aca tac     1248
 Gln Ser Ser Leu Thr Glu Ile Lys Gly Ser Val Tyr Glu Thr Thr Tyr
                 405                 410                 415

 agt cct cct gaa tgt cca ttc tgt gga aaa ata gag gag cac agt gaa     1296
 Ser Pro Pro Glu Cys Pro Phe Cys Gly Lys Ile Glu Glu His Ser Glu
             420                 425                 430

 gat atg gaa act cat gtg aaa aca aag cat gcc aat ctt tta gac att     1344
 Asp Met Glu Thr His Val Lys Thr Lys His Ala Asn Leu Leu Asp Ile
         435                 440                 445

 cca ttg gaa ggt aaa gtt ttc att tca tta taa                         1377
 Pro Leu Glu Gly Lys Val Phe Ile Ser Leu 
     450                 455





      <210> 567
      <211> 585
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (1)..(585)

      <400> 567
  atg tta act ttg att ttg ctg gac ttg caa ttc atg gct cag ctt gct      48
  Met Leu Thr Leu Ile Leu Leu Asp Leu Gln Phe Met Ala Gln Leu Ala
    1               5                  10                  15

 ggg tac cag atg agc ttt aac agc acc aag tca aag cag aca aag aat       96
 Gly Tyr Gln Met Ser Phe Asn Ser Thr Lys Ser Lys Gln Thr Lys Asn
              20                  25                  30

 aac ttt gca gtg ggc tac agg act ggg gac ttc cag ctg cac act aat      144
 Asn Phe Ala Val Gly Tyr Arg Thr Gly Asp Phe Gln Leu His Thr Asn
          35                  40                  45

 gtc aat gat ggg gca gaa ttt gga gga tca gtt tat cag aaa gtt tgt      192
 Val Asn Asp Gly Ala Glu Phe Gly Gly Ser Val Tyr Gln Lys Val Cys
      50                  55                  60

 gaa gat ctt gat gct tta gta aac ctt gct tgg aca tca ggt acc agc      240
 Glu Asp Leu Asp Ala Leu Val Asn Leu Ala Trp Thr Ser Gly Thr Ser
  65                  70                  75                  80

 tgc act cgt ttt ggc ctt gca gct aaa ttt cag ttg aaa ccc att gct      288
 Cys Thr Arg Phe Gly Leu Ala Ala Lys Phe Gln Leu Lys Pro Ile Ala
                  85                  90                  95

 tcc att tct aca aaa gtc aac aac tgg ttg act ggg gtc agc tac act      336
 Ser Ile Ser Thr Lys Val Asn Asn Trp Leu Thr Gly Val Ser Tyr Thr
             100                 105                 110

 cca ccc ctg agg cct ggt gtg aag ctc acc ctg tct gct ctg aaa aag      384
 Pro Pro Leu Arg Pro Gly Val Lys Leu Thr Leu Ser Ala Leu Lys Lys
         115                 120                 125

 att gct gcc tct gga ttc aga aca acc ctc atc atg tcc cca cag agg      432
 Ile Ala Ala Ser Gly Phe Arg Thr Thr Leu Ile Met Ser Pro Gln Arg
     130                 135                 140

 agt ggg aga agt ggg tct gaa gtt ctg ggg aac ttc gtg cat acg gag      480
 Ser Gly Arg Ser Gly Ser Glu Val Leu Gly Asn Phe Val His Thr Glu
 145                 150                 155                 160

 ctg aag gcc tct gga gag gat gag gct cca ggc caa gag cac gaa gac      528
 Leu Lys Ala Ser Gly Glu Asp Glu Ala Pro Gly Gln Glu His Glu Asp
                 165                 170                 175

 agc agg tta gat tct aaa gca gtt cca cag gtc act cag ttc tac cga      576
 Ser Arg Leu Asp Ser Lys Ala Val Pro Gln Val Thr Gln Phe Tyr Arg
             180                 185                 190

 aat tcc tga                                                          585
 Asn Ser 






      <210> 568
      <211> 639
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (1)..(639)

      <400> 568
  atg aga tgc atc cag tgc gtc ctc agt aag cag ctc ctg gtc acg ttc      48
  Met Arg Cys Ile Gln Cys Val Leu Ser Lys Gln Leu Leu Val Thr Phe
    1               5                  10                  15

 att agc ctg acc ata ccc gag agg tgc tat ctc aac act atc acc ccg       96
 Ile Ser Leu Thr Ile Pro Glu Arg Cys Tyr Leu Asn Thr Ile Thr Pro
              20                  25                  30

 gat gca ctc aag agt aaa ctt cac atc ccg acc aca tta cgg cag aag      144
 Asp Ala Leu Lys Ser Lys Leu His Ile Pro Thr Thr Leu Arg Gln Lys
          35                  40                  45

 gcc tta cct tct gcg cca agt ggc tta atg tcc ttt gcc aag caa gga      192
 Ala Leu Pro Ser Ala Pro Ser Gly Leu Met Ser Phe Ala Lys Gln Gly
      50                  55                  60

 gga gtt ctg gtg cca gat ggt aag ata gca tgt ttt att tac ctt gct      240
 Gly Val Leu Val Pro Asp Gly Lys Ile Ala Cys Phe Ile Tyr Leu Ala
  65                  70                  75                  80

 aca ttt ggt atc ttg aga gcc ctt ctt gtt cag aag aac ttg atg cct      288
 Thr Phe Gly Ile Leu Arg Ala Leu Leu Val Gln Lys Asn Leu Met Pro
                  85                  90                  95

 gca ggt acg aca cta gag gat ccc atc aaa aag ctt atc caa cat gat      336
 Ala Gly Thr Thr Leu Glu Asp Pro Ile Lys Lys Leu Ile Gln His Asp
             100                 105                 110

 cag ttc cat gta tgc tgg gga ggc ctc aca atc atg gtg gga ggc aag      384
 Gln Phe His Val Cys Trp Gly Gly Leu Thr Ile Met Val Gly Gly Lys
         115                 120                 125

 gag gag caa gtc atg tct tac atg gat ggc agc agg caa aga gag cga      432
 Glu Glu Gln Val Met Ser Tyr Met Asp Gly Ser Arg Gln Arg Glu Arg
     130                 135                 140

 gct tgt gca ggg aaa ctc cca ttt tta aag cca tca gat ctc atg aga      480
 Ala Cys Ala Gly Lys Leu Pro Phe Leu Lys Pro Ser Asp Leu Met Arg
 145                 150                 155                 160

 ctt att cac tat cat ggg aac agc aca gga atg acc tgc ccc atg att      528
 Leu Ile His Tyr His Gly Asn Ser Thr Gly Met Thr Cys Pro Met Ile
                 165                 170                 175

 caa tta cct ctc act ggg tcc ctc tca caa cac atg gga att caa gac      576
 Gln Leu Pro Leu Thr Gly Ser Leu Ser Gln His Met Gly Ile Gln Asp
             180                 185                 190

 gag atc tgg gtg ggg aca cag gca aac cat atc aag agc ttt acg aca      624
 Glu Ile Trp Val Gly Thr Gln Ala Asn His Ile Lys Ser Phe Thr Thr
         195                 200                 205

 tct cag gca gaa tga                                                  639
 Ser Gln Ala Glu 
     210





      <210> 569
      <211> 363
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (1)..(363)

      <400> 569
  atg gcg ttt ctc ttc ccc att cag gtc aca gca gtg tgg gtg gga atc      48
  Met Ala Phe Leu Phe Pro Ile Gln Val Thr Ala Val Trp Val Gly Ile
    1               5                  10                  15

 cag agg ttc caa gct agt gag gaa gaa agt gaa gat gag gag ttc ttg       96
 Gln Arg Phe Gln Ala Ser Glu Glu Glu Ser Glu Asp Glu Glu Phe Leu
              20                  25                  30

 gct acc cta act ggt ggc gag cgt tct gga aaa gct cgc aaa cag tgg      144
 Ala Thr Leu Thr Gly Gly Glu Arg Ser Gly Lys Ala Arg Lys Gln Trp
          35                  40                  45

 acg cag cct tgg tgt gtg atg ttc ccc tgc ctg tgt cca tgt gtt ctc      192
 Thr Gln Pro Trp Cys Val Met Phe Pro Cys Leu Cys Pro Cys Val Leu
      50                  55                  60

 gtt gtt cag ctc cca gtt aca acg act gaa aga cct ttc att cag aag      240
 Val Val Gln Leu Pro Val Thr Thr Thr Glu Arg Pro Phe Ile Gln Lys
  65                  70                  75                  80

 ctg ttt cgt cct gtg gct gca gat gga cag ttg cac aca cta gga gat      288
 Leu Phe Arg Pro Val Ala Ala Asp Gly Gln Leu His Thr Leu Gly Asp
                  85                  90                  95

 ctc ctc aaa gaa gtt tgt cct tct gct att gat cct gaa ggc ttt gac      336
 Leu Leu Lys Glu Val Cys Pro Ser Ala Ile Asp Pro Glu Gly Phe Asp
             100                 105                 110

 aat cta caa gtt cgt tca aaa act tga                                  363
 Asn Leu Gln Val Arg Ser Lys Thr 
         115                 120





      <210> 570
      <211> 411
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (1)..(411)

      <400> 570
  atg gat ttt tcc ctc tgt gtg tct ctt aca aca att gcc act tta tac      48
  Met Asp Phe Ser Leu Cys Val Ser Leu Thr Thr Ile Ala Thr Leu Tyr
    1               5                  10                  15

 ctt gca gga cag agt gct tgc aag gcc gta gat cta cag gaa aat caa       96
 Leu Ala Gly Gln Ser Ala Cys Lys Ala Val Asp Leu Gln Glu Asn Gln
              20                  25                  30

 aag aga agg tgt act aca aaa aag gaa aaa gaa aaa tta atg tgc tta      144
 Lys Arg Arg Cys Thr Thr Lys Lys Glu Lys Glu Lys Leu Met Cys Leu
          35                  40                  45

 aca ggg ctg ttt cag gag act tgt gaa gaa gca aag gcc gat aat gaa      192
 Thr Gly Leu Phe Gln Glu Thr Cys Glu Glu Ala Lys Ala Asp Asn Glu
      50                  55                  60

 ccg agc tgt tcg ccg gca gct caa gaa ctg ttg aca agg ctg gga ttt      240
 Pro Ser Cys Ser Pro Ala Ala Gln Glu Leu Leu Thr Arg Leu Gly Phe
  65                  70                  75                  80

 tta ctg gga gaa ggg atc cca agt gcc aca cac ata acc att gaa gac      288
 Leu Leu Gly Glu Gly Ile Pro Ser Ala Thr His Ile Thr Ile Glu Asp
                  85                  90                  95

 aaa aat gaa acc atg gta atg ccc gag gaa gac act aca ttg cat acc      336
 Lys Asn Glu Thr Met Val Met Pro Glu Glu Asp Thr Thr Leu His Thr
             100                 105                 110

 tct tca gag gat gaa cga agc aat aac cat ctt ctc cct ttc ctt gag      384
 Ser Ser Glu Asp Glu Arg Ser Asn Asn His Leu Leu Pro Phe Leu Glu
         115                 120                 125

 cag gga agc cat tgt tca gtt aaa tga                                  411
 Gln Gly Ser His Cys Ser Val Lys 
     130                 135





      <210> 571
      <211> 1554
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (1)..(1554)

      <400> 571
  atg gac aga atc ctg gga cta gtg cca gtg act ctg tgg ata cgc cga      48
  Met Asp Arg Ile Leu Gly Leu Val Pro Val Thr Leu Trp Ile Arg Arg
    1               5                  10                  15

 gcg atc tgg gcg tgc act gct gtg gtg gcc ttt atg gtc agg agg cga       96
 Ala Ile Trp Ala Cys Thr Ala Val Val Ala Phe Met Val Arg Arg Arg
              20                  25                  30

 cat gca gtg aga aga agg gaa gaa ctg gcc caa agg gat tca gcc cag      144
 His Ala Val Arg Arg Arg Glu Glu Leu Ala Gln Arg Asp Ser Ala Gln
          35                  40                  45

 ggt gag gtc cac gga aag gcc agg gcc aag atg cag cca gca ccc cag      192
 Gly Glu Val His Gly Lys Ala Arg Ala Lys Met Gln Pro Ala Pro Gln
      50                  55                  60

 gcc ggt ggt ggc ctc aca tca ccc atg cca gag gtc agt cct cga ttg      240
 Ala Gly Gly Gly Leu Thr Ser Pro Met Pro Glu Val Ser Pro Arg Leu
  65                  70                  75                  80

 ctc caa acc ctc tgc tca agg gtt cag aag gaa atg agc agg tct tcc      288
 Leu Gln Thr Leu Cys Ser Arg Val Gln Lys Glu Met Ser Arg Ser Ser
                  85                  90                  95

 cat cag ggc cca gat gag ctt ctg aaa aca agt gtg aca aaa caa cct      336
 His Gln Gly Pro Asp Glu Leu Leu Lys Thr Ser Val Thr Lys Gln Pro
             100                 105                 110

 cct gaa cat cct gga atg acc gat gca aag tac acc cca cac ggt tca      384
 Pro Glu His Pro Gly Met Thr Asp Ala Lys Tyr Thr Pro His Gly Ser
         115                 120                 125

 cag cac gaa gat cat cag ggg caa acc gtg gac gat ctg aat gac agc      432
 Gln His Glu Asp His Gln Gly Gln Thr Val Asp Asp Leu Asn Asp Ser
     130                 135                 140

 aca gac cgt cag caa cct gca gag ctg cct ggc caa gaa att acg aga      480
 Thr Asp Arg Gln Gln Pro Ala Glu Leu Pro Gly Gln Glu Ile Thr Arg
 145                 150                 155                 160

 cgg aag caa cgc ttg cag gcg aag gag gag aag aag gaa agg cca gag      528
 Arg Lys Gln Arg Leu Gln Ala Lys Glu Glu Lys Lys Glu Arg Pro Glu
                 165                 170                 175

 cag gca ggg gca gga gtg gaa cgg gcc gcg aat gtc gga gtg aag tgc      576
 Gln Ala Gly Ala Gly Val Glu Arg Ala Ala Asn Val Gly Val Lys Cys
             180                 185                 190

 aga cct tcc tgg ccc aca ccc ctc cga gca tgt gct cga ggg cag tgt      624
 Arg Pro Ser Trp Pro Thr Pro Leu Arg Ala Cys Ala Arg Gly Gln Cys
         195                 200                 205

 aaa gaa ctc aca gcg gaa gtc caa agt ctt cct gca ggc ctc cct gcg      672
 Lys Glu Leu Thr Ala Glu Val Gln Ser Leu Pro Ala Gly Leu Pro Ala
     210                 215                 220

 ggg cac gag ggc aca gct gga gag gga gct tcc aaa act gca gct gag      720
 Gly His Glu Gly Thr Ala Gly Glu Gly Ala Ser Lys Thr Ala Ala Glu
 225                 230                 235                 240

 ggt tcc cgc tgc cta cac tgc acc gag aac tcc cgt gat ggg gtc tca      768
 Gly Ser Arg Cys Leu His Cys Thr Glu Asn Ser Arg Asp Gly Val Ser
                 245                 250                 255

 cgg gag tcc acg gag gag aac gcc tac tgc ctg gac ctc gac cag aga      816
 Arg Glu Ser Thr Glu Glu Asn Ala Tyr Cys Leu Asp Leu Asp Gln Arg
             260                 265                 270

 ctt cga aag gtg cac gaa aac act tgc aac cac tac aag aag atg acc      864
 Leu Arg Lys Val His Glu Asn Thr Cys Asn His Tyr Lys Lys Met Thr
         275                 280                 285

 caa gac ctg gcc cag gaa tcg aaa aaa gac act tcc aat ttt cag agg      912
 Gln Asp Leu Ala Gln Glu Ser Lys Lys Asp Thr Ser Asn Phe Gln Arg
     290                 295                 300

 gag atc ttc ttc cgt gag aaa atg gcc cag gaa ggc cgg atg gct gct      960
 Glu Ile Phe Phe Arg Glu Lys Met Ala Gln Glu Gly Arg Met Ala Ala
 305                 310                 315                 320

 gta tcc act gag aca gcg ctc cag ccg ctc cgg gaa gaa aat gac cac     1008
 Val Ser Thr Glu Thr Ala Leu Gln Pro Leu Arg Glu Glu Asn Asp His
                 325                 330                 335

 agc agg cag aag cca gct gat ttt gag gcc aag ttc cag ctt ctc cgg     1056
 Ser Arg Gln Lys Pro Ala Asp Phe Glu Ala Lys Phe Gln Leu Leu Arg
             340                 345                 350

 ggt ggt gct ttg gct cct ggg gtt ctg ccc gca gcc cac agg ggc ccg     1104
 Gly Gly Ala Leu Ala Pro Gly Val Leu Pro Ala Ala His Arg Gly Pro
         355                 360                 365

 gaa gtg tca ggg gga cca tgg gac gac agg gcc ccc aga agg gag gca     1152
 Glu Val Ser Gly Gly Pro Trp Asp Asp Arg Ala Pro Arg Arg Glu Ala
     370                 375                 380

 ggt cac aat caa tca gaa gat gtt gga gaa tcc tat tca cag gaa tac     1200
 Gly His Asn Gln Ser Glu Asp Val Gly Glu Ser Tyr Ser Gln Glu Tyr
 385                 390                 395                 400

 ttg gta gat tcg cag ttt gaa gag tcc cca cca tgg gca cat gga ttg     1248
 Leu Val Asp Ser Gln Phe Glu Glu Ser Pro Pro Trp Ala His Gly Leu
                 405                 410                 415

 cag gag gct aga gga cca gga aag gca att gcg ggt gtc cct gtg aga     1296
 Gln Glu Ala Arg Gly Pro Gly Lys Ala Ile Ala Gly Val Pro Val Arg
             420                 425                 430

 agc gaa gag ggg gtg act gca gca gag gca gcg gat tgg cag gag gtt     1344
 Ser Glu Glu Gly Val Thr Ala Ala Glu Ala Ala Asp Trp Gln Glu Val
         435                 440                 445

 ccc ctg aag gat gct aag gaa tac gct gaa tcc ata ggt gcc atc gtg     1392
 Pro Leu Lys Asp Ala Lys Glu Tyr Ala Glu Ser Ile Gly Ala Ile Val
     450                 455                 460

 gtt gag aca agt gca aaa aat gct att aat atc gaa gag ctc ttt caa     1440
 Val Glu Thr Ser Ala Lys Asn Ala Ile Asn Ile Glu Glu Leu Phe Gln
 465                 470                 475                 480

 gga atc agt gcc atg cta gac cct ggg gac agc acg gtg aca agg cgc     1488
 Gly Ile Ser Ala Met Leu Asp Pro Gly Asp Ser Thr Val Thr Arg Arg
                 485                 490                 495

 agt gac agt gga gtc ggg gag aca gct gtg ggc aca gtc aga tcg gtg     1536
 Ser Asp Ser Gly Val Gly Glu Thr Ala Val Gly Thr Val Arg Ser Val
             500                 505                 510

 tct ggt gac tct tgg taa                                             1554
 Ser Gly Asp Ser Trp 
         515





      <210> 572
      <211> 678
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (1)..(678)

      <400> 572
  atg ttg ctc agg ctc ttc tgg aac ttc tgg gct caa gcc atc ctc ctg      48
  Met Leu Leu Arg Leu Phe Trp Asn Phe Trp Ala Gln Ala Ile Leu Leu
    1               5                  10                  15

 ctt cag cct ccc aaa gtg ctg gga tta cag gtg tat aaa ccc atc cgt       96
 Leu Gln Pro Pro Lys Val Leu Gly Leu Gln Val Tyr Lys Pro Ile Arg
              20                  25                  30

 gtt gaa gac ata aat aac att att cgt att gct cta tac atc aca gcc      144
 Val Glu Asp Ile Asn Asn Ile Ile Arg Ile Ala Leu Tyr Ile Thr Ala
          35                  40                  45

 aga gtc tgg aaa ctg cct aca tac cta cgt aca gaa gaa cag ctt ggt      192
 Arg Val Trp Lys Leu Pro Thr Tyr Leu Arg Thr Glu Glu Gln Leu Gly
      50                  55                  60

 ggc cta atg cca gaa tgt caa gga gcc ctg aac cgc ccc cct ttt ctg      240
 Gly Leu Met Pro Glu Cys Gln Gly Ala Leu Asn Arg Pro Pro Phe Leu
  65                  70                  75                  80

 cca tgg ggc aag cag aat gag aca gag cca ggg aga acc tgt gca gtg      288
 Pro Trp Gly Lys Gln Asn Glu Thr Glu Pro Gly Arg Thr Cys Ala Val
                  85                  90                  95

 aga caa cgg atg gaa gag gaa aac act aaa tcc caa gaa cag ctg gaa      336
 Arg Gln Arg Met Glu Glu Glu Asn Thr Lys Ser Gln Glu Gln Leu Glu
             100                 105                 110

 gca aac ttc gag agc ccc cag ctg cca gtc cat tct aca cag agg att      384
 Ala Asn Phe Glu Ser Pro Gln Leu Pro Val His Ser Thr Gln Arg Ile
         115                 120                 125

 agg gat aag aac gac tgc tct gaa ggc ctg gag tca gct ggg tca cac      432
 Arg Asp Lys Asn Asp Cys Ser Glu Gly Leu Glu Ser Ala Gly Ser His
     130                 135                 140

 ctg cag gtg ctg cag cct ggg cat ttc aac agc tcc agt tct atc tta      480
 Leu Gln Val Leu Gln Pro Gly His Phe Asn Ser Ser Ser Ser Ile Leu
 145                 150                 155                 160

 aag atc aat tct gcc agg aca tgg atg gag ctg gaa gtc atc atc ctc      528
 Lys Ile Asn Ser Ala Arg Thr Trp Met Glu Leu Glu Val Ile Ile Leu
                 165                 170                 175

 agc aaa cta agg cag aaa cag aaa aac caa aca ctg cat gtt ctc act      576
 Ser Lys Leu Arg Gln Lys Gln Lys Asn Gln Thr Leu His Val Leu Thr
             180                 185                 190

 gat aag tgg gag ctg aat gat ggg aac aca tgg aca cat agc ggg aaa      624
 Asp Lys Trp Glu Leu Asn Asp Gly Asn Thr Trp Thr His Ser Gly Lys
         195                 200                 205

 caa cac act ttg ggg tct ggg ggt gga aag gag agc atc aga aag aat      672
 Gln His Thr Leu Gly Ser Gly Gly Gly Lys Glu Ser Ile Arg Lys Asn
     210                 215                 220

 agc taa                                                              678
 Ser 
 225





      <210> 573
      <211> 852
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (1)..(852)

      <400> 573
  atg acc tgt ttg tat tct tta tta act gct gta tac aaa tac agc cag      48
  Met Thr Cys Leu Tyr Ser Leu Leu Thr Ala Val Tyr Lys Tyr Ser Gln
    1               5                  10                  15

 ctt gct tta att atg gaa act ggt cct tcc cgg tgg agg gac act gtc       96
 Leu Ala Leu Ile Met Glu Thr Gly Pro Ser Arg Trp Arg Asp Thr Val
              20                  25                  30

 cca gtg agg cga gga ggg gag tgt gcc tgc cag gag gta ggt gtg gct      144
 Pro Val Arg Arg Gly Gly Glu Cys Ala Cys Gln Glu Val Gly Val Ala
          35                  40                  45

 gtg caa atg gca gtg ccg agc agt agg ctc aga gct ggc agt gcc aga      192
 Val Gln Met Ala Val Pro Ser Ser Arg Leu Arg Ala Gly Ser Ala Arg
      50                  55                  60

 gat cct ctt gct att cct act gtg gtg tac gga cag ctt atg gtt tac      240
 Asp Pro Leu Ala Ile Pro Thr Val Val Tyr Gly Gln Leu Met Val Tyr
  65                  70                  75                  80

 ttc tta cag ttt cct gtt tca gat aag ggg aag cat ggc caa gat ggt      288
 Phe Leu Gln Phe Pro Val Ser Asp Lys Gly Lys His Gly Gln Asp Gly
                  85                  90                  95

 tct gtg agt cag gcc cag aag ggt acg aca gtg cca gcc cac agg gcc      336
 Ser Val Ser Gln Ala Gln Lys Gly Thr Thr Val Pro Ala His Arg Ala
             100                 105                 110

 atc ctg gtg gcc cgt tgt gaa gtg atg gca gcc atg ttt aat ggt aat      384
 Ile Leu Val Ala Arg Cys Glu Val Met Ala Ala Met Phe Asn Gly Asn
         115                 120                 125

 tac atg gaa gca aag agt gtc ctg att ccc gtt tat ggt gtt tcc aaa      432
 Tyr Met Glu Ala Lys Ser Val Leu Ile Pro Val Tyr Gly Val Ser Lys
     130                 135                 140

 gag act ttc ttg tca ttt tta gaa tac ctg tac aca gac tcc tgc tgc      480
 Glu Thr Phe Leu Ser Phe Leu Glu Tyr Leu Tyr Thr Asp Ser Cys Cys
 145                 150                 155                 160

 cca gct ggc ata ttc cag gcc atg tgt ctc ctg atc tgt gcc gag atg      528
 Pro Ala Gly Ile Phe Gln Ala Met Cys Leu Leu Ile Cys Ala Glu Met
                 165                 170                 175

 tac caa gtg tcc aga ctg cag cac atc tgt gag ctg ttc atc att acc      576
 Tyr Gln Val Ser Arg Leu Gln His Ile Cys Glu Leu Phe Ile Ile Thr
             180                 185                 190

 cag ctg cag agc atg cca agc agg gaa ctg gca tcc atg aac ctt gat      624
 Gln Leu Gln Ser Met Pro Ser Arg Glu Leu Ala Ser Met Asn Leu Asp
         195                 200                 205

 ata gtt gac ctg ctt aaa aag gcc aag gaa tat att tgt tca atc act      672
 Ile Val Asp Leu Leu Lys Lys Ala Lys Glu Tyr Ile Cys Ser Ile Thr
     210                 215                 220

 aca gag tgt cag tac ttc ttg aac tat tat ctg gca tcc aac atg tct      720
 Thr Glu Cys Gln Tyr Phe Leu Asn Tyr Tyr Leu Ala Ser Asn Met Ser
 225                 230                 235                 240

 ata cct atc aac ttt gac gtc cag ggt tac aaa agc atg aca act ttt      768
 Ile Pro Ile Asn Phe Asp Val Gln Gly Tyr Lys Ser Met Thr Thr Phe
                 245                 250                 255

 atc tcc atc cac att gct aaa atg gag cca cat gat ggg gca aat tcc      816
 Ile Ser Ile His Ile Ala Lys Met Glu Pro His Asp Gly Ala Asn Ser
             260                 265                 270

 aga tct gtg aca gct gaa tgc ttg cct cca agc tga                      852
 Arg Ser Val Thr Ala Glu Cys Leu Pro Pro Ser 
         275                 280





      <210> 574
      <211> 1026
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (1)..(1026)

      <400> 574
  atg aca gcc agg tgc atg ctc agt aga ctt atc ttg ttg aat aga cat      48
  Met Thr Ala Arg Cys Met Leu Ser Arg Leu Ile Leu Leu Asn Arg His
    1               5                  10                  15

 aga gca gtt cac atg ctg tca ggc tcg tgt ggt gaa ttg cat gtg aca       96
 Arg Ala Val His Met Leu Ser Gly Ser Cys Gly Glu Leu His Val Thr
              20                  25                  30

 caa gct gca cac ttg ttt cag tta cta ttg gtg ctt aac aaa ttg ccc      144
 Gln Ala Ala His Leu Phe Gln Leu Leu Leu Val Leu Asn Lys Leu Pro
          35                  40                  45

 cca aac tta gtg gct tta aaa gaa caa cag tca ttc att tct tca aat      192
 Pro Asn Leu Val Ala Leu Lys Glu Gln Gln Ser Phe Ile Ser Ser Asn
      50                  55                  60

 cta caa ttt gag cag gac ttt gca gaa cac ttt atc tct gct gca cac      240
 Leu Gln Phe Glu Gln Asp Phe Ala Glu His Phe Ile Ser Ala Ala His
  65                  70                  75                  80

 agc gcc tgc cag gtg ggt cag cag ggg cca cag cat cca ctt cca aga      288
 Ser Ala Cys Gln Val Gly Gln Gln Gly Pro Gln His Pro Leu Pro Arg
                  85                  90                  95

 tgg ctc att cgc atg act ggc agc tgt ggc aga tgg gtc ctg tcc cct      336
 Trp Leu Ile Arg Met Thr Gly Ser Cys Gly Arg Trp Val Leu Ser Pro
             100                 105                 110

 gac caa tgc cag ctg atg ggt aag cgc tgc ttg gag cac agt gtt gag      384
 Asp Gln Cys Gln Leu Met Gly Lys Arg Cys Leu Glu His Ser Val Glu
         115                 120                 125

 aaa gat tct caa agt ctg gga tcc aca agg aag gat att aca ata gct      432
 Lys Asp Ser Gln Ser Leu Gly Ser Thr Arg Lys Asp Ile Thr Ile Ala
     130                 135                 140

 gct gtg cag agc aat att gca gcc ctt gct cct gcc cag ccc gtc aag      480
 Ala Val Gln Ser Asn Ile Ala Ala Leu Ala Pro Ala Gln Pro Val Lys
 145                 150                 155                 160

 cct cta aga aga gca ctt tct agg ggc ttt cct gtg att gat cac aca      528
 Pro Leu Arg Arg Ala Leu Ser Arg Gly Phe Pro Val Ile Asp His Thr
                 165                 170                 175

 tca gct aga ctg aga ttt tca aaa cct ctt gtg aat tgc cct ctt ggt      576
 Ser Ala Arg Leu Arg Phe Ser Lys Pro Leu Val Asn Cys Pro Leu Gly
             180                 185                 190

 aca gaa ggc tca cac agt cga caa aag aaa acg ttt ttc ttg gga gat      624
 Thr Glu Gly Ser His Ser Arg Gln Lys Lys Thr Phe Phe Leu Gly Asp
         195                 200                 205

 ggg cag aag ctg aag gac tgg cat gac aag gag gcc atc cgg agg gac      672
 Gly Gln Lys Leu Lys Asp Trp His Asp Lys Glu Ala Ile Arg Arg Asp
     210                 215                 220

 gct cag cgc gta ggt acg gag ggc agg att ggc cat ggg ata gaa atg      720
 Ala Gln Arg Val Gly Thr Glu Gly Arg Ile Gly His Gly Ile Glu Met
 225                 230                 235                 240

 tct ctc cct tat gag att aca act aaa aca agg agc agt aat aag agc      768
 Ser Leu Pro Tyr Glu Ile Thr Thr Lys Thr Arg Ser Ser Asn Lys Ser
                 245                 250                 255

 cag cat tta ttg aac acc tat gga aat gga gaa caa gga aga cct tac      816
 Gln His Leu Leu Asn Thr Tyr Gly Asn Gly Glu Gln Gly Arg Pro Tyr
             260                 265                 270

 ccc atg acc gat gct gag aga gtg gat cag gca tac cga gaa aat gga      864
 Pro Met Thr Asp Ala Glu Arg Val Asp Gln Ala Tyr Arg Glu Asn Gly
         275                 280                 285

 ttt aac atc tac gtc agt gat aaa atc tcc ttg aat cgc tct ctc cca      912
 Phe Asn Ile Tyr Val Ser Asp Lys Ile Ser Leu Asn Arg Ser Leu Pro
     290                 295                 300

 gat atc cgg cac cca aaa agc tgc act ggg gac tgc gta gcc aga gaa      960
 Asp Ile Arg His Pro Lys Ser Cys Thr Gly Asp Cys Val Ala Arg Glu
 305                 310                 315                 320

 cgg aag cga ggc agt ttg gcc cag act cac tgg acc tgc aaa tgg gag     1008
 Arg Lys Arg Gly Ser Leu Ala Gln Thr His Trp Thr Cys Lys Trp Glu
                 325                 330                 335

 tca gcc agc tgg ctc tga                                             1026
 Ser Ala Ser Trp Leu 
             340





      <210> 575
      <211> 858
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (1)..(858)

      <400> 575
  atg gag att cct gct gtg atc tta aca gtt gct ccc atc ctc cac tta      48
  Met Glu Ile Pro Ala Val Ile Leu Thr Val Ala Pro Ile Leu His Leu
    1               5                  10                  15

 act agc tgt ggt ttc cct gtg act gga gat ggt cta aaa caa gca gag       96
 Thr Ser Cys Gly Phe Pro Val Thr Gly Asp Gly Leu Lys Gln Ala Glu
              20                  25                  30

 ggc aaa tgt gct cct gaa gaa tgg aat ccc aca aag ttc ata aaa cta      144
 Gly Lys Cys Ala Pro Glu Glu Trp Asn Pro Thr Lys Phe Ile Lys Leu
          35                  40                  45

 aca gac aat caa gca tgc ttt gct tgt ggc tta tgg cct tta tcc gag      192
 Thr Asp Asn Gln Ala Cys Phe Ala Cys Gly Leu Trp Pro Leu Ser Glu
      50                  55                  60

 att caa agg aga acc tca agg act gtt act ata ata tcc agg ata tca      240
 Ile Gln Arg Arg Thr Ser Arg Thr Val Thr Ile Ile Ser Arg Ile Ser
  65                  70                  75                  80

 gcc cta aga gaa aag gga aat gga aga aag cct acc agc att tca gga      288
 Ala Leu Arg Glu Lys Gly Asn Gly Arg Lys Pro Thr Ser Ile Ser Gly
                  85                  90                  95

 tca gta aat gaa atg aga cag gtt ctg gtg aaa gac cag gtg tca atg      336
 Ser Val Asn Glu Met Arg Gln Val Leu Val Lys Asp Gln Val Ser Met
             100                 105                 110

 cca aga gtt ctc cct aca att att ttt gtt cca gac gag gca ggc ttc      384
 Pro Arg Val Leu Pro Thr Ile Ile Phe Val Pro Asp Glu Ala Gly Phe
         115                 120                 125

 agt gca gga gcc gtg tgg cca tgt gca gct cct ctg tgg ggc agc agc      432
 Ser Ala Gly Ala Val Trp Pro Cys Ala Ala Pro Leu Trp Gly Ser Ser
     130                 135                 140

 tgg act cca cta aaa gtg gaa aac tgc tcg ttc tac att aga ctc tct      480
 Trp Thr Pro Leu Lys Val Glu Asn Cys Ser Phe Tyr Ile Arg Leu Ser
 145                 150                 155                 160

 ttc gca att tcg gta ggt ggt gat gag ctg aag ata gca aaa ttg gtt      528
 Phe Ala Ile Ser Val Gly Gly Asp Glu Leu Lys Ile Ala Lys Leu Val
                 165                 170                 175

 tca gct ttt cct gaa aga gct tat gat tta gtt ggt cac caa cat caa      576
 Ser Ala Phe Pro Glu Arg Ala Tyr Asp Leu Val Gly His Gln His Gln
             180                 185                 190

 aga cca aag gta gat aaa acc aca aag atg ggg aga aac cag agc aga      624
 Arg Pro Lys Val Asp Lys Thr Thr Lys Met Gly Arg Asn Gln Ser Arg
         195                 200                 205

 aag gct gaa aat tcc aaa aac cag aac atg tct tct cct cca aag gaa      672
 Lys Ala Glu Asn Ser Lys Asn Gln Asn Met Ser Ser Pro Pro Lys Glu
     210                 215                 220

 cac aac tcc tct cca gca agg gaa caa aac tgg atg gag aat gag ttt      720
 His Asn Ser Ser Pro Ala Arg Glu Gln Asn Trp Met Glu Asn Glu Phe
 225                 230                 235                 240

 gat gag ttg aga gaa gta ggc ttc aga agg cct cta gga aac ggg cat      768
 Asp Glu Leu Arg Glu Val Gly Phe Arg Arg Pro Leu Gly Asn Gly His
                 245                 250                 255

 cca tac tgt act gaa ata ccc tac cca agt gtg tca ttt atc aca gct      816
 Pro Tyr Cys Thr Glu Ile Pro Tyr Pro Ser Val Ser Phe Ile Thr Ala
             260                 265                 270

 aag aaa gga ggt gac caa atg aaa cac act aaa gta gaa tga              858
 Lys Lys Gly Gly Asp Gln Met Lys His Thr Lys Val Glu 
         275                 280                 285





      <210> 576
      <211> 1620
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (1)..(1620)

      <400> 576
  atg ctg agc aaa cta gga att gaa aga aac tgc ctc atc aga aac cct      48
  Met Leu Ser Lys Leu Gly Ile Glu Arg Asn Cys Leu Ile Arg Asn Pro
    1               5                  10                  15

 aga gtt aac acc ata ctt cat ggt aaa aga ctg aag gct tct gct aca       96
 Arg Val Asn Thr Ile Leu His Gly Lys Arg Leu Lys Ala Ser Ala Thr
              20                  25                  30

 act ggg aac agg cca aga tgt ctg ctc gca tta ctc ctg tta agc ata      144
 Thr Gly Asn Arg Pro Arg Cys Leu Leu Ala Leu Leu Leu Leu Ser Ile
          35                  40                  45

 atg ctg gga gtc cca ggc tat gtc caa gca tca aag aga gac aaa aaa      192
 Met Leu Gly Val Pro Gly Tyr Val Gln Ala Ser Lys Arg Asp Lys Lys
      50                  55                  60

 ttt ttt gcc tgt gct cca aat tac tcg tat gca gcc ctt tgt gag tgc      240
 Phe Phe Ala Cys Ala Pro Asn Tyr Ser Tyr Ala Ala Leu Cys Glu Cys
  65                  70                  75                  80

 ctt cgt cga gta ttc atc tat cgt cag cct gct ccc atg tcc act gta      288
 Leu Arg Arg Val Phe Ile Tyr Arg Gln Pro Ala Pro Met Ser Thr Val
                  85                  90                  95

 ctt tac aac aga aag gaa ggc agg caa gta gga cag gtt gct aag cag      336
 Leu Tyr Asn Arg Lys Glu Gly Arg Gln Val Gly Gln Val Ala Lys Gln
             100                 105                 110

 caa gta gca agc cta gaa acc aat gat cct att tta gga ttt cag gca      384
 Gln Val Ala Ser Leu Glu Thr Asn Asp Pro Ile Leu Gly Phe Gln Ala
         115                 120                 125

 aca aat gag aga tta ttt gtt ctt act acc aaa aac ctc ttt tta ata      432
 Thr Asn Glu Arg Leu Phe Val Leu Thr Thr Lys Asn Leu Phe Leu Ile
     130                 135                 140

 aaa ctt cta gaa gtt gct tat atg ggt cat ggc act ctt cca tct tca      480
 Lys Leu Leu Glu Val Ala Tyr Met Gly His Gly Thr Leu Pro Ser Ser
 145                 150                 155                 160

 aag tta gca att gct gat ttt ggg cag atg tgt agc ttc aca ata ggt      528
 Lys Leu Ala Ile Ala Asp Phe Gly Gln Met Cys Ser Phe Thr Ile Gly
                 165                 170                 175

 tct cta ttg gct tac aat gaa gga gat tat acc aat ggc tat acc ctg      576
 Ser Leu Leu Ala Tyr Asn Glu Gly Asp Tyr Thr Asn Gly Tyr Thr Leu
             180                 185                 190

 aat ttc ctc act gga gtt cct ggt caa att ttt tat gct gaa gag aga      624
 Asn Phe Leu Thr Gly Val Pro Gly Gln Ile Phe Tyr Ala Glu Glu Arg
         195                 200                 205

 cct ggg tgt aca agt gtg gca tca gca ttt gct ctt ctg atg aag aag      672
 Pro Gly Cys Thr Ser Val Ala Ser Ala Phe Ala Leu Leu Met Lys Lys
     210                 215                 220

 ctt tta ctc atg gca gaa gat gaa ggg gga aca ggc ttg tca cat ggc      720
 Leu Leu Leu Met Ala Glu Asp Glu Gly Gly Thr Gly Leu Ser His Gly
 225                 230                 235                 240

 aag aga ggg aac aag aga aag gag gag gtc agc atc atc ttg ata cca      768
 Lys Arg Gly Asn Lys Arg Lys Glu Glu Val Ser Ile Ile Leu Ile Pro
                 245                 250                 255

 aaa gct agc aga gat aca aca gaa aaa gaa tat ttc agg aca ata tcc      816
 Lys Ala Ser Arg Asp Thr Thr Glu Lys Glu Tyr Phe Arg Thr Ile Ser
             260                 265                 270

 ctg atg aac atc gat gca aaa atc ttc aat aaa ata ctg gca aac caa      864
 Leu Met Asn Ile Asp Ala Lys Ile Phe Asn Lys Ile Leu Ala Asn Gln
         275                 280                 285

 atc cag cag cac atc aaa aag ctt ttc cac cat ggt caa gtc ggc ttc      912
 Ile Gln Gln His Ile Lys Lys Leu Phe His His Gly Gln Val Gly Phe
     290                 295                 300

 atc cat ggg atg caa ggc tgg ttc aac ata cag aaa tca ata aac gta      960
 Ile His Gly Met Gln Gly Trp Phe Asn Ile Gln Lys Ser Ile Asn Val
 305                 310                 315                 320

 atc cat cac ata aac aga acc aat gac aaa aac cac atg att gtc tca     1008
 Ile His His Ile Asn Arg Thr Asn Asp Lys Asn His Met Ile Val Ser
                 325                 330                 335

 ata gat gca gaa aag gcc ttt gac aaa att caa cac ctc ttc atg ctg     1056
 Ile Asp Ala Glu Lys Ala Phe Asp Lys Ile Gln His Leu Phe Met Leu
             340                 345                 350

 aaa act ctc agt aaa cta ggt att gat gga atg tat ctc aaa ata ata     1104
 Lys Thr Leu Ser Lys Leu Gly Ile Asp Gly Met Tyr Leu Lys Ile Ile
         355                 360                 365

 aga gct att tat gac aaa ctc aca gcc aat acc ata ctg aat ggg caa     1152
 Arg Ala Ile Tyr Asp Lys Leu Thr Ala Asn Thr Ile Leu Asn Gly Gln
     370                 375                 380

 aag ctc gaa gca ttc cct ttg aaa acc agc aca agg caa gga tgt cct     1200
 Lys Leu Glu Ala Phe Pro Leu Lys Thr Ser Thr Arg Gln Gly Cys Pro
 385                 390                 395                 400

 ctc tca cca ctc tca ttc aac ata gta ttg gaa gtt ctg acc agg gca     1248
 Leu Ser Pro Leu Ser Phe Asn Ile Val Leu Glu Val Leu Thr Arg Ala
                 405                 410                 415

 ata agg caa gag aaa gaa ata aag tgt att caa ata gga aga gag gaa     1296
 Ile Arg Gln Glu Lys Glu Ile Lys Cys Ile Gln Ile Gly Arg Glu Glu
             420                 425                 430

 gtc aag ttg tct ctg ttt gca gat gac atg att gtg tat tta gaa aac     1344
 Val Lys Leu Ser Leu Phe Ala Asp Asp Met Ile Val Tyr Leu Glu Asn
         435                 440                 445

 ccc att gtc tca gtc caa aat ctc ctt aag cta ata agc aac ttc agc     1392
 Pro Ile Val Ser Val Gln Asn Leu Leu Lys Leu Ile Ser Asn Phe Ser
     450                 455                 460

 aaa gtc tca gaa tac aaa atc aat gtg caa aaa tca caa gca ttc cta     1440
 Lys Val Ser Glu Tyr Lys Ile Asn Val Gln Lys Ser Gln Ala Phe Leu
 465                 470                 475                 480

 tac acc agt aat agc caa atc att agt gaa cac ccg ttc aca att gct     1488
 Tyr Thr Ser Asn Ser Gln Ile Ile Ser Glu His Pro Phe Thr Ile Ala
                 485                 490                 495

 aca aac aga ata aaa tat cta gga ata caa ttt aca aag gat gtg aag     1536
 Thr Asn Arg Ile Lys Tyr Leu Gly Ile Gln Phe Thr Lys Asp Val Lys
             500                 505                 510

 gac ctc ttc aag gag aac tac aaa caa ctg ctc aag gaa ata aga aag     1584
 Asp Leu Phe Lys Glu Asn Tyr Lys Gln Leu Leu Lys Glu Ile Arg Lys
         515                 520                 525

 gac aca aac aaa tgg aaa aac att cca tgc tca tag                     1620
 Asp Thr Asn Lys Trp Lys Asn Ile Pro Cys Ser 
     530                 535





      <210> 577
      <211> 1008
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (1)..(1008)

      <400> 577
  atg aag ctg gcc agt ggc ttc ttg gtt ttg tgg ctc agc ctt ggg ggt      48
  Met Lys Leu Ala Ser Gly Phe Leu Val Leu Trp Leu Ser Leu Gly Gly
    1               5                  10                  15

 ggc ctg gct cag agc gac acg agc cct gac acg gag gag tcc tat tca       96
 Gly Leu Ala Gln Ser Asp Thr Ser Pro Asp Thr Glu Glu Ser Tyr Ser
              20                  25                  30

 gac tgg ggc ctt cgg cac ctc cgg gga agc ttt gaa tcc gtc aat agc      144
 Asp Trp Gly Leu Arg His Leu Arg Gly Ser Phe Glu Ser Val Asn Ser
          35                  40                  45

 tac ttc gat tct ttt ctg gag ctg ctg gga ggg aag aat gga gtc tgt      192
 Tyr Phe Asp Ser Phe Leu Glu Leu Leu Gly Gly Lys Asn Gly Val Cys
      50                  55                  60

 cag tac agg tgc cga tat ggt gag tgt gcg gtt tct ctt tct gta aaa      240
 Gln Tyr Arg Cys Arg Tyr Gly Glu Cys Ala Val Ser Leu Ser Val Lys
  65                  70                  75                  80

 act gtt gct ggt gga ccc atg gac agc ccc aga gag gtc acg atc tgt      288
 Thr Val Ala Gly Gly Pro Met Asp Ser Pro Arg Glu Val Thr Ile Cys
                  85                  90                  95

 ctt gca ctt ttt cct gtt atc cac tta gag ctg cca gat tta gca gat      336
 Leu Ala Leu Phe Pro Val Ile His Leu Glu Leu Pro Asp Leu Ala Asp
             100                 105                 110

 aaa aat caa aac agc att aaa aga ctt aag caa att tta gtt gcg gag      384
 Lys Asn Gln Asn Ser Ile Lys Arg Leu Lys Gln Ile Leu Val Ala Glu
         115                 120                 125

 cct ctg gct ggg cag ggt gga agc cag cag caa ctg ggg aaa aag tca      432
 Pro Leu Ala Gly Gln Gly Gly Ser Gln Gln Gln Leu Gly Lys Lys Ser
     130                 135                 140

 aag tgg ttt gaa agt cat tat tct tct gtg aca tca tca tca tca tca      480
 Lys Trp Phe Glu Ser His Tyr Ser Ser Val Thr Ser Ser Ser Ser Ser
 145                 150                 155                 160

 tca cct gat ttg gat atg gac ttg ggc att cca gca atg aca aag tgc      528
 Ser Pro Asp Leu Asp Met Asp Leu Gly Ile Pro Ala Met Thr Lys Cys
                 165                 170                 175

 tgc aac cag ctg gat gtc tgt tat gac act tgc ggt gcc aac aaa tat      576
 Cys Asn Gln Leu Asp Val Cys Tyr Asp Thr Cys Gly Ala Asn Lys Tyr
             180                 185                 190

 cgc tgt gat gca aaa ttc cga tgg tgt ctc cac tcg atc tgc tct gac      624
 Arg Cys Asp Ala Lys Phe Arg Trp Cys Leu His Ser Ile Cys Ser Asp
         195                 200                 205

 ctt aag cgg agt ctg ggc ttt gtc tcc aaa gtg gaa gtg aaa gct ata      672
 Leu Lys Arg Ser Leu Gly Phe Val Ser Lys Val Glu Val Lys Ala Ile
     210                 215                 220

 ggc gag att cgg tgt gtt ctg ggt ggt atg gcc ata gat ggg aaa gct      720
 Gly Glu Ile Arg Cys Val Leu Gly Gly Met Ala Ile Asp Gly Lys Ala
 225                 230                 235                 240

 atg gga aac ata gtt gtt cat gaa ttg agg aag aag aaa aag gaa aaa      768
 Met Gly Asn Ile Val Val His Glu Leu Arg Lys Lys Lys Lys Glu Lys
                 245                 250                 255

 gga ttt ttt agt tca aat gga gaa agg tgc cag gaa agg ctt cat gga      816
 Gly Phe Phe Ser Ser Asn Gly Glu Arg Cys Gln Glu Arg Leu His Gly
             260                 265                 270

 gga agt aaa ccc tcc atg aat ctc gaa gaa cca gta agg atc aga cag      864
 Gly Ser Lys Pro Ser Met Asn Leu Glu Glu Pro Val Arg Ile Arg Gln
         275                 280                 285

 gaa gaa aag gcg ggg aag aag ata tca ggc aga gga aac agc atg cgc      912
 Glu Glu Lys Ala Gly Lys Lys Ile Ser Gly Arg Gly Asn Ser Met Arg
     290                 295                 300

 aaa gtc aga agg gtg ttc agg agt gac agt ttg gga att gtc aat aat      960
 Lys Val Arg Arg Val Phe Arg Ser Asp Ser Leu Gly Ile Val Asn Asn
 305                 310                 315                 320

 tcc ctt tgg cag gag cag aaa ctc gag ggg gct gag gtc aga ggg taa     1008
 Ser Leu Trp Gln Glu Gln Lys Leu Glu Gly Ala Glu Val Arg Gly 
                 325                 330                 335





      <210> 578
      <211> 2112
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (1)..(2112)

      <400> 578
  atg agc aga ctg ctg ggg ggg acg ctg gag cgc gtc tgc aag gct gtg      48
  Met Ser Arg Leu Leu Gly Gly Thr Leu Glu Arg Val Cys Lys Ala Val
    1               5                  10                  15

 ctc ctt ctc tgc ctg ctg cac ttc ctc gtg gcc gtc atc ctc tac ttt       96
 Leu Leu Leu Cys Leu Leu His Phe Leu Val Ala Val Ile Leu Tyr Phe
              20                  25                  30

 gac gtc tac gcc cag cac ctg gcc ttc ttc agc cgc ttc agt gcc cga      144
 Asp Val Tyr Ala Gln His Leu Ala Phe Phe Ser Arg Phe Ser Ala Arg
          35                  40                  45

 ggc cct gcc cat gcc ctc cac cca gct gct agc agc agc agc agc agc      192
 Gly Pro Ala His Ala Leu His Pro Ala Ala Ser Ser Ser Ser Ser Ser
      50                  55                  60

 agc aac tgc tcc cgg ccc aac gcc acc gcc tct agc tcc ggg ctc cct      240
 Ser Asn Cys Ser Arg Pro Asn Ala Thr Ala Ser Ser Ser Gly Leu Pro
  65                  70                  75                  80

 gag gtc ccc agt gcc ctg ccc ggt ccc acg gct ccc acg ctg cca ccc      288
 Glu Val Pro Ser Ala Leu Pro Gly Pro Thr Ala Pro Thr Leu Pro Pro
                  85                  90                  95

 tgt cct gac tcg cca cct ggt ctt gtg ggc aga ctg ctg atc gag ttc      336
 Cys Pro Asp Ser Pro Pro Gly Leu Val Gly Arg Leu Leu Ile Glu Phe
             100                 105                 110

 acc tca ccc atg ccc ctg gag cgg gtg cag agg gag aac cca ggc gtg      384
 Thr Ser Pro Met Pro Leu Glu Arg Val Gln Arg Glu Asn Pro Gly Val
         115                 120                 125

 ctc atg ggc ggc cga tac aca ccg ccc gac tgc acc cca gcc cag acg      432
 Leu Met Gly Gly Arg Tyr Thr Pro Pro Asp Cys Thr Pro Ala Gln Thr
     130                 135                 140

 gtg gcg gtc atc atc ccc ttt aga cac cgg gaa cac cac ctg cgc tac      480
 Val Ala Val Ile Ile Pro Phe Arg His Arg Glu His His Leu Arg Tyr
 145                 150                 155                 160

 tgg ctc cac tat cta cac ccc atc ttg agg cgg cag cgg ctg cgc tac      528
 Trp Leu His Tyr Leu His Pro Ile Leu Arg Arg Gln Arg Leu Arg Tyr
                 165                 170                 175

 ggc gtc tat gtc atc aac cag gcc tca ccc cat ggt ggt gca ggc ctt      576
 Gly Val Tyr Val Ile Asn Gln Ala Ser Pro His Gly Gly Ala Gly Leu
             180                 185                 190

 ggg tat gct gta gga gga gat gtt gag ggc cct gag gag agg gag tta      624
 Gly Tyr Ala Val Gly Gly Asp Val Glu Gly Pro Glu Glu Arg Glu Leu
         195                 200                 205

 gac cct gaa aga agg atg aag cct gta gaa ccc ttt ggg cat ggt gag      672
 Asp Pro Glu Arg Arg Met Lys Pro Val Glu Pro Phe Gly His Gly Glu
     210                 215                 220

 gac acc ttc aac cgg gcc aag ctg ctt aac gtg ggc ttc cta gag gcg      720
 Asp Thr Phe Asn Arg Ala Lys Leu Leu Asn Val Gly Phe Leu Glu Ala
 225                 230                 235                 240

 ctg aag gag gat gcc gcc tat gac tgc ttc atc ttc agc gat gtg gac      768
 Leu Lys Glu Asp Ala Ala Tyr Asp Cys Phe Ile Phe Ser Asp Val Asp
                 245                 250                 255

 ctg gtc ccc atg gat gac cgc aac cta tac cgc tgc ggc gac caa ccc      816
 Leu Val Pro Met Asp Asp Arg Asn Leu Tyr Arg Cys Gly Asp Gln Pro
             260                 265                 270

 cgc cac ttt gcc att gcc atg gac aag ttt ggc ttc cgg ctt ccc tat      864
 Arg His Phe Ala Ile Ala Met Asp Lys Phe Gly Phe Arg Leu Pro Tyr
         275                 280                 285

 gct ggc tac ttt gga ggt gtg tca ggc ctg agt aag gct cag ttt ctg      912
 Ala Gly Tyr Phe Gly Gly Val Ser Gly Leu Ser Lys Ala Gln Phe Leu
     290                 295                 300

 aga atc aat ggc ttc ccc aat gag tac tgg ggc tgg ggt ggc gag gat      960
 Arg Ile Asn Gly Phe Pro Asn Glu Tyr Trp Gly Trp Gly Gly Glu Asp
 305                 310                 315                 320

 gat gac atc ttc aac cgg atc tcc ctg act ggg atg aag atc tca cgc     1008
 Asp Asp Ile Phe Asn Arg Ile Ser Leu Thr Gly Met Lys Ile Ser Arg
                 325                 330                 335

 cca gac atc cga atc ggc cgc tac cgc atg atc aag cac gac cgc gac     1056
 Pro Asp Ile Arg Ile Gly Arg Tyr Arg Met Ile Lys His Asp Arg Asp
             340                 345                 350

 aag cat aac gaa cct aac cct cag agg ttt acc aag att caa aac acg     1104
 Lys His Asn Glu Pro Asn Pro Gln Arg Phe Thr Lys Ile Gln Asn Thr
         355                 360                 365

 aag ctg acc atg aag cgg gac ggc att ggg tca gtg cgg tac cag gtc     1152
 Lys Leu Thr Met Lys Arg Asp Gly Ile Gly Ser Val Arg Tyr Gln Val
     370                 375                 380

 ttg gag gtg tct cgg caa cca ctc ttc acc aat atc aca gtg gac att     1200
 Leu Glu Val Ser Arg Gln Pro Leu Phe Thr Asn Ile Thr Val Asp Ile
 385                 390                 395                 400

 ggg cgg cct ccg tcg tcc gag ccg ggg acg gcg gcg tcg gtg ggt cat     1248
 Gly Arg Pro Pro Ser Ser Glu Pro Gly Thr Ala Ala Ser Val Gly His
                 405                 410                 415

 gct ccg gca ctc ccc ctc gct gtg gga gct ggt gga gga gca cgt tcc     1296
 Ala Pro Ala Leu Pro Leu Ala Val Gly Ala Gly Gly Gly Ala Arg Ser
             420                 425                 430

 gct ccg gga gcg acg cga agt gaa gag gat ctg ggg gag gcg gcg gtg     1344
 Ala Pro Gly Ala Thr Arg Ser Glu Glu Asp Leu Gly Glu Ala Ala Val
         435                 440                 445

 gac ctg agc ctg gag ctg cgg gcg gag gtg gcg atg tta cgg gca ctg     1392
 Asp Leu Ser Leu Glu Leu Arg Ala Glu Val Ala Met Leu Arg Ala Leu
     450                 455                 460

 ctc caa gag gct cga tcc tct caa gcc ccc agc tcc cgc ccc atc tct     1440
 Leu Gln Glu Ala Arg Ser Ser Gln Ala Pro Ser Ser Arg Pro Ile Ser
 465                 470                 475                 480

 gac ccc tct tct ctt ctg gca cca ccg cct ctc cta aag gac ctc ttg     1488
 Asp Pro Ser Ser Leu Leu Ala Pro Pro Pro Leu Leu Lys Asp Leu Leu
                 485                 490                 495

 cgc cag gag ctc cgg cag ttg ctc cag ggt ctc cgc cac aaa gcc atc     1536
 Arg Gln Glu Leu Arg Gln Leu Leu Gln Gly Leu Arg His Lys Ala Ile
             500                 505                 510

 tgt gag ggc agg gac cag gcc caa gct tgg gtc cag tat agc ccc agg     1584
 Cys Glu Gly Arg Asp Gln Ala Gln Ala Trp Val Gln Tyr Ser Pro Arg
         515                 520                 525

 gtc ctg cac ttt gcc ttg gag gag ccc agg tgt gat ttg cca gaa cag     1632
 Val Leu His Phe Ala Leu Glu Glu Pro Arg Cys Asp Leu Pro Glu Gln
     530                 535                 540

 gag ata ttc cag atg aga ggt ggt ggg ccc agc ggt cac aga gat ctc     1680
 Glu Ile Phe Gln Met Arg Gly Gly Gly Pro Ser Gly His Arg Asp Leu
 545                 550                 555                 560

 agc atc atc aag gac caa ctg aac gtg tcc aac att gac cag gtg gcc     1728
 Ser Ile Ile Lys Asp Gln Leu Asn Val Ser Asn Ile Asp Gln Val Ala
                 565                 570                 575

 aga cac ctg agg ggc ctt ctg gag gag gag tgt cac acc ttg gag agg     1776
 Arg His Leu Arg Gly Leu Leu Glu Glu Glu Cys His Thr Leu Glu Arg
             580                 585                 590

 gag atc ctc atc ctg cag cgc tgc ctg gaa gag gag tat ttg agg cct     1824
 Glu Ile Leu Ile Leu Gln Arg Cys Leu Glu Glu Glu Tyr Leu Arg Pro
         595                 600                 605

 tgc cac ccc tct gag gca gcc ctg gag ccc acc ctg gca gag cta aag     1872
 Cys His Pro Ser Glu Ala Ala Leu Glu Pro Thr Leu Ala Glu Leu Lys
     610                 615                 620

 gaa cag aag aag gcc atg gag cag gag ctg cag gca tct gtg ggg cct     1920
 Glu Gln Lys Lys Ala Met Glu Gln Glu Leu Gln Ala Ser Val Gly Pro
 625                 630                 635                 640

 tct tgt gtc tct ccc aac cac agt gct gcc tgc ctg cac ctc ctc tgg     1968
 Ser Cys Val Ser Pro Asn His Ser Ala Ala Cys Leu His Leu Leu Trp
                 645                 650                 655

 agc cct acc ttc gac ctc gag gcc agt cgg cta ccc acc gct ggg gac     2016
 Ser Pro Thr Phe Asp Leu Glu Ala Ser Arg Leu Pro Thr Ala Gly Asp
             660                 665                 670

 ggc agc ttc agt gca gcc cca ggg aag ggc cag ctt cca cac cca tgt     2064
 Gly Ser Phe Ser Ala Ala Pro Gly Lys Gly Gln Leu Pro His Pro Cys
         675                 680                 685

 cca gtg cag cac ccc aag ccc cag cct gaa ggg ctg gtc acc gag tag     2112
 Pro Val Gln His Pro Lys Pro Gln Pro Glu Gly Leu Val Thr Glu 
     690                 695                 700





      <210> 579
      <211> 465
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (1)..(465)

      <400> 579
  atg gtg cag cta ctt tgg aag aca gcc tgg cag ttt ctt aca aaa cta      48
  Met Val Gln Leu Leu Trp Lys Thr Ala Trp Gln Phe Leu Thr Lys Leu
    1               5                  10                  15

 aac cta ctc tta ccc tat gat cca gca atc acg ctt ctt gtt att cat       96
 Asn Leu Leu Leu Pro Tyr Asp Pro Ala Ile Thr Leu Leu Val Ile His
              20                  25                  30

 cca gat gaa ttg caa att tat gtc cgc aca aaa acc tgc aca gat gtt      144
 Pro Asp Glu Leu Gln Ile Tyr Val Arg Thr Lys Thr Cys Thr Asp Val
          35                  40                  45

 cat agc agc ttt att cat aat tgc caa aac tta gaa gca acc aag ata      192
 His Ser Ser Phe Ile His Asn Cys Gln Asn Leu Glu Ala Thr Lys Ile
      50                  55                  60

 tcc ttc agg cgc ttt ggt ctg gaa aca gct gtg agt aat ctg gag cac      240
 Ser Phe Arg Arg Phe Gly Leu Glu Thr Ala Val Ser Asn Leu Glu His
  65                  70                  75                  80

 cca gag cag aaa gct tta tca gtc agc ctg ccc caa aag ctg ctg cga      288
 Pro Glu Gln Lys Ala Leu Ser Val Ser Leu Pro Gln Lys Leu Leu Arg
                  85                  90                  95

 aaa cta tct gct ggt gca gtc atg cct cca act gcc cta ttt tta gtg      336
 Lys Leu Ser Ala Gly Ala Val Met Pro Pro Thr Ala Leu Phe Leu Val
             100                 105                 110

 aaa cgc act ttc cag ggc tgt gct tct gat gaa gga gca agc cga ctt      384
 Lys Arg Thr Phe Gln Gly Cys Ala Ser Asp Glu Gly Ala Ser Arg Leu
         115                 120                 125

 ggt ctt aag aca tac ata gtc agt gac aac caa gcc act tcc act cgt      432
 Gly Leu Lys Thr Tyr Ile Val Ser Asp Asn Gln Ala Thr Ser Thr Arg
     130                 135                 140

 ctg cct gat tta ggg ttt tct gca ggt tta tga                          465
 Leu Pro Asp Leu Gly Phe Ser Ala Gly Leu 
 145                 150





      <210> 580
      <211> 1092
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (1)..(1092)

      <400> 580
  atg gtg ggc aga aga aca gga aaa cct gct tac agc cat ttc cta ctt      48
  Met Val Gly Arg Arg Thr Gly Lys Pro Ala Tyr Ser His Phe Leu Leu
    1               5                  10                  15

 ctc act ctg tgt tct ctg ggt cct aag gct gaa gag att ctg cag aca       96
 Leu Thr Leu Cys Ser Leu Gly Pro Lys Ala Glu Glu Ile Leu Gln Thr
              20                  25                  30

 tac ttg aaa tcc aag gag tct gtg acc gat gca att cta cag aca gac      144
 Tyr Leu Lys Ser Lys Glu Ser Val Thr Asp Ala Ile Leu Gln Thr Asp
          35                  40                  45

 cag att ctc aca gaa aag gaa aag gag att gaa gtg gaa tgt gta aaa      192
 Gln Ile Leu Thr Glu Lys Glu Lys Glu Ile Glu Val Glu Cys Val Lys
      50                  55                  60

 gct gaa tct gca cag gct tca gca aaa atg gtg gag gaa atg caa ata      240
 Ala Glu Ser Ala Gln Ala Ser Ala Lys Met Val Glu Glu Met Gln Ile
  65                  70                  75                  80

 aag tat cag cag atg atg gaa gag aaa gag aag agt tat caa gaa cat      288
 Lys Tyr Gln Gln Met Met Glu Glu Lys Glu Lys Ser Tyr Gln Glu His
                  85                  90                  95

 gtg aaa caa ttg act gag aag atg gag agg gag agg gcc cag ttg ctg      336
 Val Lys Gln Leu Thr Glu Lys Met Glu Arg Glu Arg Ala Gln Leu Leu
             100                 105                 110

 gaa gag caa gag aag acc ctc act agt aaa ctt cag gaa gcc ata ccc      384
 Glu Glu Gln Glu Lys Thr Leu Thr Ser Lys Leu Gln Glu Ala Ile Pro
         115                 120                 125

 ata gga aaa ggg gga gag tac tac atc agg gga aca ccc cat ggg aca      432
 Ile Gly Lys Gly Gly Glu Tyr Tyr Ile Arg Gly Thr Pro His Gly Thr
     130                 135                 140

 aaa gaa tct gaa caa cag cct tca gcc tta gac ctt ctc tct gac aga      480
 Lys Glu Ser Glu Gln Gln Pro Ser Ala Leu Asp Leu Leu Ser Asp Arg
 145                 150                 155                 160

 gcc tac cca aat gag aag gaa cca gaa aac caa ctc tgg tta tat gac      528
 Ala Tyr Pro Asn Glu Lys Glu Pro Glu Asn Gln Leu Trp Leu Tyr Asp
                 165                 170                 175

 aaa aca agg ccc ttc aac acc ccc caa aaa tca tcc tgg ttc acc agc      576
 Lys Thr Arg Pro Phe Asn Thr Pro Gln Lys Ser Ser Trp Phe Thr Ser
             180                 185                 190

 aat gga tcc aaa cca aga aga aat ccc gat tta tct gaa aaa gaa ttc      624
 Asn Gly Ser Lys Pro Arg Arg Asn Pro Asp Leu Ser Glu Lys Glu Phe
         195                 200                 205

 agg agg tta gtt act aag cta atc agg gaa gga cca gag aaa gaa atg      672
 Arg Arg Leu Val Thr Lys Leu Ile Arg Glu Gly Pro Glu Lys Glu Met
     210                 215                 220

 caa aat gct ttg gaa agt ctc agc aac aga att gaa caa gta caa gaa      720
 Gln Asn Ala Leu Glu Ser Leu Ser Asn Arg Ile Glu Gln Val Gln Glu
 225                 230                 235                 240

 aga aat tca gag ctc aaa gac aag gtc ttt gaa tta acc caa tcc aac      768
 Arg Asn Ser Glu Leu Lys Asp Lys Val Phe Glu Leu Thr Gln Ser Asn
                 245                 250                 255

 aaa gac aaa gaa aaa aga ata cga aaa tat gaa caa atc ctc caa gaa      816
 Lys Asp Lys Glu Lys Arg Ile Arg Lys Tyr Glu Gln Ile Leu Gln Glu
             260                 265                 270

 gag act cac cga aca cat aag gac tca cat aaa gtt aaa gta aat ggg      864
 Glu Thr His Arg Thr His Lys Asp Ser His Lys Val Lys Val Asn Gly
         275                 280                 285

 tgg aaa aag cca ttt cat gca aat gga cac caa aag cga cca gag gca      912
 Trp Lys Lys Pro Phe His Ala Asn Gly His Gln Lys Arg Pro Glu Ala
     290                 295                 300

 cct tcc aaa gtt att cca acc cga tcc ctc cac ttg tac aag ccc agc      960
 Pro Ser Lys Val Ile Pro Thr Arg Ser Leu His Leu Tyr Lys Pro Ser
 305                 310                 315                 320

 ggc ccc aca gct tgc cca tcc ttg caa acc agt cct cgt cct ata acc     1008
 Gly Pro Thr Ala Cys Pro Ser Leu Gln Thr Ser Pro Arg Pro Ile Thr
                 325                 330                 335

 tgc ccc aac ccg atc agt cgc ata cat ccg att cga gcc ctg ggg cca     1056
 Cys Pro Asn Pro Ile Ser Arg Ile His Pro Ile Arg Ala Leu Gly Pro
             340                 345                 350

 aat tcc ata ccc ata tcc aag tcc ccg ccc cac taa                     1092
 Asn Ser Ile Pro Ile Ser Lys Ser Pro Pro His 
         355                 360





      <210> 581
      <211> 1656
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (1)..(1656)

      <400> 581
  atg gtt ttc agc tcc atc atg tca ttt aag gtc ttg tct acc ctg ttt      48
  Met Val Phe Ser Ser Ile Met Ser Phe Lys Val Leu Ser Thr Leu Phe
    1               5                  10                  15

 att cta gtt agc cat tcg tct aac ctt ttt tca agg ttt tta cct tcc       96
 Ile Leu Val Ser His Ser Ser Asn Leu Phe Ser Arg Phe Leu Pro Ser
              20                  25                  30

 ttg caa tgg gtt caa aca tcc tcc ttt agc tca gag aag ttt gtt att      144
 Leu Gln Trp Val Gln Thr Ser Ser Phe Ser Ser Glu Lys Phe Val Ile
          35                  40                  45

 acc gac ctt ctg aag cct act tct gtc aac ttg tca aag tca ttc tcc      192
 Thr Asp Leu Leu Lys Pro Thr Ser Val Asn Leu Ser Lys Ser Phe Ser
      50                  55                  60

 gtc cag ctt tct tcc att gct ggt ctg ttg gag ttt gct gga ggt cca      240
 Val Gln Leu Ser Ser Ile Ala Gly Leu Leu Glu Phe Ala Gly Gly Pro
  65                  70                  75                  80

 ctc tat gga tac cct gtt tgc ctg ggt atc acc agc gaa cgc tgt aga      288
 Leu Tyr Gly Tyr Pro Val Cys Leu Gly Ile Thr Ser Glu Arg Cys Arg
                  85                  90                  95

 aca gaa cat caa ata ttg cag aac agc aaa tgt tgc tgc ctg atc ctt      336
 Thr Glu His Gln Ile Leu Gln Asn Ser Lys Cys Cys Cys Leu Ile Leu
             100                 105                 110

 cct ctg gaa gct tca tct cag agg agc tct tgg ctg tat gag gtg tca      384
 Pro Leu Glu Ala Ser Ser Gln Arg Ser Ser Trp Leu Tyr Glu Val Ser
         115                 120                 125

 gaa gta atg gct gaa cac aat ccc cag tat ctc att gag cta aat gga      432
 Glu Val Met Ala Glu His Asn Pro Gln Tyr Leu Ile Glu Leu Asn Gly
     130                 135                 140

 aat aaa cca gca gag gag ctc ttt atg gat gag cta ttt cgt act ctt      480
 Asn Lys Pro Ala Glu Glu Leu Phe Met Asp Glu Leu Phe Arg Thr Leu
 145                 150                 155                 160

 gca tct tat aaa ctt att gca cca aga tac aga tgg caa aga agt aaa      528
 Ala Ser Tyr Lys Leu Ile Ala Pro Arg Tyr Arg Trp Gln Arg Ser Lys
                 165                 170                 175

 tgg gga cgt aca tgt cct gtg aat tta aaa gat ggt aac att tat tca      576
 Trp Gly Arg Thr Cys Pro Val Asn Leu Lys Asp Gly Asn Ile Tyr Ser
             180                 185                 190

 gga tta cca gat tat tct aaa acg tta act gta aaa cag cct cag gca      624
 Gly Leu Pro Asp Tyr Ser Lys Thr Leu Thr Val Lys Gln Pro Gln Ala
         195                 200                 205

 ggt tct tca gga gat att cca gaa ggc att gtt gtc gta aga gat gac      672
 Gly Ser Ser Gly Asp Ile Pro Glu Gly Ile Val Val Val Arg Asp Asp
     210                 215                 220

 agc tcc atg cat gtt ctt gtc cct gaa gac ctt cca gtg gga caa gat      720
 Ser Ser Met His Val Leu Val Pro Glu Asp Leu Pro Val Gly Gln Asp
 225                 230                 235                 240

 ata gag gag gaa gac agt gat att gat aat cct gac ccc ata ttg gaa      768
 Ile Glu Glu Glu Asp Ser Asp Ile Asp Asn Pro Asp Pro Ile Leu Glu
                 245                 250                 255

 ttt gtg gaa gaa ctt gaa gac aga tca ata aaa cat ttc cag tct gaa      816
 Phe Val Glu Glu Leu Glu Asp Arg Ser Ile Lys His Phe Gln Ser Glu
             260                 265                 270

 aaa cag agg gag aaa aaa ata ttg aaa gaa atg aac aga gct tca ggg      864
 Lys Gln Arg Glu Lys Lys Ile Leu Lys Glu Met Asn Arg Ala Ser Gly
         275                 280                 285

 acc tgt ggg aaa atc aga tgg tct aat gta gtc gac tat gcc caa ctt      912
 Thr Cys Gly Lys Ile Arg Trp Ser Asn Val Val Asp Tyr Ala Gln Leu
     290                 295                 300

 gtt cag cca cgt ttt gat aaa gcc cgt gaa aca tta gta gaa aat acc      960
 Val Gln Pro Arg Phe Asp Lys Ala Arg Glu Thr Leu Val Glu Asn Thr
 305                 310                 315                 320

 ata gct gag gcc act gca gca gca att aaa gtt gtg aaa gaa aag ctt     1008
 Ile Ala Glu Ala Thr Ala Ala Ala Ile Lys Val Val Lys Glu Lys Leu
                 325                 330                 335

 ctc agg gaa ctg caa gct aga aaa caa gct gaa aca gct tta aga gaa     1056
 Leu Arg Glu Leu Gln Ala Arg Lys Gln Ala Glu Thr Ala Leu Arg Glu
             340                 345                 350

 ttt caa agg caa tat gaa aaa atg gag ttt gga gta ttc cca atg gag     1104
 Phe Gln Arg Gln Tyr Glu Lys Met Glu Phe Gly Val Phe Pro Met Glu
         355                 360                 365

 gca aca cac tca tca att gat gaa gaa ggg tac att caa ggc tcc caa     1152
 Ala Thr His Ser Ser Ile Asp Glu Glu Gly Tyr Ile Gln Gly Ser Gln
     370                 375                 380

 agg gac aga ggc agc tct tta gtg gac acc gaa gaa gcc aaa aca aag     1200
 Arg Asp Arg Gly Ser Ser Leu Val Asp Thr Glu Glu Ala Lys Thr Lys
 385                 390                 395                 400

 tca gaa aat gtc ctc cat gat caa gct gct aaa gtt gat aaa gat ggc     1248
 Ser Glu Asn Val Leu His Asp Gln Ala Ala Lys Val Asp Lys Asp Gly
                 405                 410                 415

 att cac aat gtt tta ttc aca gat gga aaa gaa act ggt gaa aca ttc     1296
 Ile His Asn Val Leu Phe Thr Asp Gly Lys Glu Thr Gly Glu Thr Phe
             420                 425                 430

 aca ttt aaa agg cat tct caa gat gct agt caa gat gta aag ttg tat     1344
 Thr Phe Lys Arg His Ser Gln Asp Ala Ser Gln Asp Val Lys Leu Tyr
         435                 440                 445

 tca gat aca gcc cca aca gaa gac ttg ata gaa gag gta act gca gat     1392
 Ser Asp Thr Ala Pro Thr Glu Asp Leu Ile Glu Glu Val Thr Ala Asp
     450                 455                 460

 cat cca gag gtt gtg acc atg att gaa gag act ata aaa atg tca cag     1440
 His Pro Glu Val Val Thr Met Ile Glu Glu Thr Ile Lys Met Ser Gln
 465                 470                 475                 480

 gat ata aac ttt gaa cag cca tat gaa aaa cat gct gaa atc tta cag     1488
 Asp Ile Asn Phe Glu Gln Pro Tyr Glu Lys His Ala Glu Ile Leu Gln
                 485                 490                 495

 gaa gtc ctt gga gag aaa tat tat gag tac cta cta tct gcc cta tac     1536
 Glu Val Leu Gly Glu Lys Tyr Tyr Glu Tyr Leu Leu Ser Ala Leu Tyr
             500                 505                 510

 cat gtt aga tac cag gaa tct gaa gat gaa tta aac aca gcc ctt tcc     1584
 His Val Arg Tyr Gln Glu Ser Glu Asp Glu Leu Asn Thr Ala Leu Ser
         515                 520                 525

 ttt aag gag cta tcc gtc aga gtt tat tct gga gca tat aaa tct aca     1632
 Phe Lys Glu Leu Ser Val Arg Val Tyr Ser Gly Ala Tyr Lys Ser Thr
     530                 535                 540

 agg aat cct aca ctt ctg ata tag                                     1656
 Arg Asn Pro Thr Leu Leu Ile 
 545                 550





      <210> 582
      <211> 1422
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (1)..(1422)

      <400> 582
  atg cct gct atg cgc tcc tgc acg cgc cgg acc ctg gaa ttc tct ctg      48
  Met Pro Ala Met Arg Ser Cys Thr Arg Arg Thr Leu Glu Phe Ser Leu
    1               5                  10                  15

 gcc gcc tcc ctc tgc gct acg cca tac tgc ttc ctc ctc tct cag atg       96
 Ala Ala Ser Leu Cys Ala Thr Pro Tyr Cys Phe Leu Leu Ser Gln Met
              20                  25                  30

 cag atg cgc ttt gat ggg cgc ctg ggc ttc cct ggc gga ttc gtg gac      144
 Gln Met Arg Phe Asp Gly Arg Leu Gly Phe Pro Gly Gly Phe Val Asp
          35                  40                  45

 tcg caa gac agc agc ctg gag gac ggg ctg aac cgt ggt ctg ctg gaa      192
 Ser Gln Asp Ser Ser Leu Glu Asp Gly Leu Asn Arg Gly Leu Leu Glu
      50                  55                  60

 ctg ctg ggc gag gcg gcg gcc gcc ttc cgc gtg gag cgc cct gac tac      240
 Leu Leu Gly Glu Ala Ala Ala Ala Phe Arg Val Glu Arg Pro Asp Tyr
  65                  70                  75                  80

 cgc agc tct cac gcc gga tca agg cca cgt gtt gtg gcc cac ttc tat      288
 Arg Ser Ser His Ala Gly Ser Arg Pro Arg Val Val Ala His Phe Tyr
                  85                  90                  95

 gcc aaa tct ctg acg ctc gag cag ctg ttg gct gtg gag gcc agc gca      336
 Ala Lys Ser Leu Thr Leu Glu Gln Leu Leu Ala Val Glu Ala Ser Ala
             100                 105                 110

 aca ggg gcc aag gac cac ggg ctg gag agg gtt gag ccc act ggg cct      384
 Thr Gly Ala Lys Asp His Gly Leu Glu Arg Val Glu Pro Thr Gly Pro
         115                 120                 125

 cct tta gat agg agc ctt ggg ctt gtt tct gct gga gta tta aga gtt      432
 Pro Leu Asp Arg Ser Leu Gly Leu Val Ser Ala Gly Val Leu Arg Val
     130                 135                 140

 gtg gca tct gct cta gaa aga tct gct aaa gag agg atg gag gta tct      480
 Val Ala Ser Ala Leu Glu Arg Ser Ala Lys Glu Arg Met Glu Val Ser
 145                 150                 155                 160

 gaa aaa cgg aac caa tgg gtt tac aac atc ctg tta tcc agc atc ctg      528
 Glu Lys Arg Asn Gln Trp Val Tyr Asn Ile Leu Leu Ser Ser Ile Leu
                 165                 170                 175

 tta tta caa cat cct gta att cca ggc tgt gga tgt agg gaa aag cca      576
 Leu Leu Gln His Pro Val Ile Pro Gly Cys Gly Cys Arg Glu Lys Pro
             180                 185                 190

 ggt acc att atg aac ttg gaa cag ctc ttt agg tac atg gct cag ccc      624
 Gly Thr Ile Met Asn Leu Glu Gln Leu Phe Arg Tyr Met Ala Gln Pro
         195                 200                 205

 tct acc tgc agc ctt gag tcc tgg gca ttc tgc ctt agg ata gtg gaa      672
 Ser Thr Cys Ser Leu Glu Ser Trp Ala Phe Cys Leu Arg Ile Val Glu
     210                 215                 220

 tgg ggg atg gtt ggt ggg ggt ggg gca gag gca gag aag gat ttg aaa      720
 Trp Gly Met Val Gly Gly Gly Gly Ala Glu Ala Glu Lys Asp Leu Lys
 225                 230                 235                 240

 ggc gat ggc aag gga ttg ggc ctt gca gca ccg ccc agg ctc gga ttg      768
 Gly Asp Gly Lys Gly Leu Gly Leu Ala Ala Pro Pro Arg Leu Gly Leu
                 245                 250                 255

 gtc cga ggt gag acc cgc ccc tct gcc cat tgg gcc ttc ggg aca gca      816
 Val Arg Gly Glu Thr Arg Pro Ser Ala His Trp Ala Phe Gly Thr Ala
             260                 265                 270

 gag gag cag tgt ccg gcc atg gcc gga gcc cgc agg ctg gag cta ggc      864
 Glu Glu Gln Cys Pro Ala Met Ala Gly Ala Arg Arg Leu Glu Leu Gly
         275                 280                 285

 gag gcc ctg gcg ctg ggg tcg ggc tgg cgt cat gcg tgc cac gct ctc      912
 Glu Ala Leu Ala Leu Gly Ser Gly Trp Arg His Ala Cys His Ala Leu
     290                 295                 300

 ctc tac gcg ccg gac cct ggg atg ctc ttc ggc cgc atc ccg ctg cgc      960
 Leu Tyr Ala Pro Asp Pro Gly Met Leu Phe Gly Arg Ile Pro Leu Arg
 305                 310                 315                 320

 tac gcc ata ctg atg cag atg cgc ttc gat gga cgc ctg ggc ttc ccc     1008
 Tyr Ala Ile Leu Met Gln Met Arg Phe Asp Gly Arg Leu Gly Phe Pro
                 325                 330                 335

 ggc gga ttc gtg gac acg cag gac aga agc cta gag gac ggg ctg aac     1056
 Gly Gly Phe Val Asp Thr Gln Asp Arg Ser Leu Glu Asp Gly Leu Asn
             340                 345                 350

 cgc gag ctg cgc gag gag ctg ggc gaa gcg gct gcc gct ttc cgc gtg     1104
 Arg Glu Leu Arg Glu Glu Leu Gly Glu Ala Ala Ala Ala Phe Arg Val
         355                 360                 365

 gag cgc act gac tac cgc agc tcc cac gtc ggg tca ggg cca cgc gtt     1152
 Glu Arg Thr Asp Tyr Arg Ser Ser His Val Gly Ser Gly Pro Arg Val
     370                 375                 380

 gtg gcc cac ttc tat gcc aag cgt ctg acg ctc gag gag ctg ttg gct     1200
 Val Ala His Phe Tyr Ala Lys Arg Leu Thr Leu Glu Glu Leu Leu Ala
 385                 390                 395                 400

 gtg gag gcc ggc gca aca cgc gcc aag gac cac ggg ctg gag gtg ctg     1248
 Val Glu Ala Gly Ala Thr Arg Ala Lys Asp His Gly Leu Glu Val Leu
                 405                 410                 415

 ggc ctg gtg cga gtg ccc ctg tat acc ctg cgg gat ggt gta gga ggc     1296
 Gly Leu Val Arg Val Pro Leu Tyr Thr Leu Arg Asp Gly Val Gly Gly
             420                 425                 430

 ctg cct acc ttc ctg gag aat tcc ttt att ggc tct gcg cgg gag cag     1344
 Leu Pro Thr Phe Leu Glu Asn Ser Phe Ile Gly Ser Ala Arg Glu Gln
         435                 440                 445

 tta ctt gaa gct ctc cag gac ttg gga ctg ctg cag tct ggc tct att     1392
 Leu Leu Glu Ala Leu Gln Asp Leu Gly Leu Leu Gln Ser Gly Ser Ile
     450                 455                 460

 tca ggc ctt aag att cca gct cat cac tag                             1422
 Ser Gly Leu Lys Ile Pro Ala His His 
 465                 470





      <210> 583
      <211> 522
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (1)..(522)

      <400> 583
  atg agg ttt ttc acc agc gtg gcc tgc tat gga tct tgt ctc ttt gca      48
  Met Arg Phe Phe Thr Ser Val Ala Cys Tyr Gly Ser Cys Leu Phe Ala
    1               5                  10                  15

 tct gag ttg ctg atc aga tgc aag gac tgg ctc aaa gga aga cca gct       96
 Ser Glu Leu Leu Ile Arg Cys Lys Asp Trp Leu Lys Gly Arg Pro Ala
              20                  25                  30

 ctc ttc act gcc ctg cta gct tgt gtc ctt tat ctt tgt gag tgg act      144
 Leu Phe Thr Ala Leu Leu Ala Cys Val Leu Tyr Leu Cys Glu Trp Thr
          35                  40                  45

 ggt gcc aag cat gtc cca ggg tca tct tgt gag tct gaa tgt tcg att      192
 Gly Ala Lys His Val Pro Gly Ser Ser Cys Glu Ser Glu Cys Ser Ile
      50                  55                  60

 gaa cct aaa aat act gat gtt gaa atg ctt cag gcc agt aca tct aac      240
 Glu Pro Lys Asn Thr Asp Val Glu Met Leu Gln Ala Ser Thr Ser Asn
  65                  70                  75                  80

 cca atc cct gga gat ggt ttc tct cgg gcc act aag gac tct atg atc      288
 Pro Ile Pro Gly Asp Gly Phe Ser Arg Ala Thr Lys Asp Ser Met Ile
                  85                  90                  95

 cgc aag ttt tta gaa ggc aac agc atg gga atg acc aat ctg gag aga      336
 Arg Lys Phe Leu Glu Gly Asn Ser Met Gly Met Thr Asn Leu Glu Arg
             100                 105                 110

 gat cag tgc cat ctt ggt cag gaa gaa gat gtt tat cac acg gtg gat      384
 Asp Gln Cys His Leu Gly Gln Glu Glu Asp Val Tyr His Thr Val Asp
         115                 120                 125

 gac gat gag gcc ttt tct gtg gac ctg gcc agc agg ccc cct gtc cca      432
 Asp Asp Glu Ala Phe Ser Val Asp Leu Ala Ser Arg Pro Pro Val Pro
     130                 135                 140

 gtg ccc aga cca gag acc act gct cct ggt gct cac cag ctg cct gac      480
 Val Pro Arg Pro Glu Thr Thr Ala Pro Gly Ala His Gln Leu Pro Asp
 145                 150                 155                 160

 aac gaa cca tac att ttt aaa ggc aag tat ggc agg gaa tga              522
 Asn Glu Pro Tyr Ile Phe Lys Gly Lys Tyr Gly Arg Glu 
                 165                 170





      <210> 584
      <211> 2064
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (834)..(1208)

      <400> 584
 atggaagtgg cgctgacagc agatctcaca gccgcgggtg gggacagagt cttcttcggc     60

 tgcccaaggt accaatatcc agatcagcca gctgtcatcg caagtggtcc cgtcccccag    120

 agcttcgtcc ctgggtcggg tcatgctgtt ggggacgccc tgagcgctct cagcgcaccg    180

 ttggccctgc tcgctcccca ccggggtaca gctgtatctg gcaccatcac ctctggccca    240

 aactctcacc acagcctggc agaggaacct gagacctcaa tccacgtttt ggagaagaat    300

 gcacaggagc ccagcatgaa cactatgtat acaactgcat ggaccgggtc ttctaacacg    360

 gagccaaaag attctggagg ggacaggtcc catgactcaa tgaacatgct tgtccagctc    420

 atctggaaac ctgctgcctt caaataccat ctcatcgttt caacacaata tgatgacagt    480

 gcaccccaca gaaccatgga aactccctgg ggttggatct ggacacacct ggaaatagat    540

 gaccactgca aagacaaaga tggtggcgat gagattcatg aggttgggaa gattctggcg    600

 gtagaacgcc tcccgaaggg ctcggacctt gtctgtgcgt gtggccagca gatggaaaag    660

 tgcgatgata gcaccttcaa attccattcc tctgaaaggg gtcatccact gaagaggggg    720

 ctcagagctg gcaaatctac tttcctggac aatcttgaga agtacaagta cccattcaac    780

 agctatgaag tgcaggctgc ccttggctgg cactccccaa aagccagtca cca   tga     836
                                                              Met
                                                                1

 tgg tct tga caa ata cct gaa ctc cta caa tgc cat ccc cct ctt gcc      884
 Val Thr Gly Phe Trp Gly Val Pro Ala Lys Gly Ser Leu His Phe Ile
               5                  10                  15

 ttt tca cat cct gtc aaa ctt tgc ctt ctg gac ctg ctt ctc cca att      932
 Ala Val Glu Trp Val Leu Val Leu Leu Lys Ile Val Gln Glu Ser Arg
          20                  25                  30

 tac ctt gga ttt cct aaa ttt ata caa agt act caa gga agc atc aaa      980
 Phe Ala Ser Ser Glu Pro Pro Leu Gln Trp Met Thr Pro Phe Arg Gly
      35                  40                  45

 tga gtt cag ctc agg tgg gca aaa cca gat aac taa cat gaa cag tgg     1028
 Met Glu Phe Glu Gly Ala Ile Ile Ala Leu Phe His Leu Leu Ala Thr
  50                  55                  60                  65

 aac aat cag tga acc aat aca agg gtt aaa taa gct agc aat taa aag     1076
 Arg Thr Asp Lys Val Arg Ala Leu Arg Glu Ala Phe Tyr Arg Gln Asn
                  70                  75                  80

 ctg tat cac tgg tct aaa gat aga aga tca agt aga aaa tca gcg caa     1124
 Leu Pro Asn Leu Met Asn Leu Ile Ala Thr Ile Phe Val Phe Ala Val
              85                  90                  95

 gag gaa aga tat acg aaa act aat gac ctt caa gga aat cag aaa cca     1172
 Val Ile Tyr Phe Gln Val Cys Pro Asp Pro Thr Pro Gly Ser Phe His
         100                 105                 110

 gcg gaa caa caa gca tga aga tga cca tga tga gga tgac ggtggtgacg     1222
 Gly Ser Val Gly Cys Thr Val Ile Ile Leu Cys 
     115                 120

 atggtagcat gtcagcatgc accgtcagct cccctctcca ggagccagcc catgtgctct   1282

 ggtcgtttaa catttatgaa acttgttttg tggtccagca tatggtttat ttcgatgatg   1342

 gctctatgtg cgctgagaat ggacattctg ccattgttaa gcgtgagatg gttaaattgg   1402

 ctgaccgtgt tcgagtcttc tgtgtcctta ttggaagagg agtgtgggaa tcatgcatga   1462

 gaattgtgga tttgtctgtt tttcctttca attctgcatc ctcagtggct ggtgagcaga   1522

 agctgacatg cacggatgtg tcggttgcct ctattacgag tattgactca gttgagtgca   1582

 aacacagcaa gcccatgggt gagttggtca gcctgggact tcccaagact gtcctagtag   1642

 gatccactgt ttcctggtcc atgtcttcct tttccttggt ttactacctt attctgcttg   1702

 agcacatcct caaggagcct cttaagaatg catggatggt agatgtggca gttttgaaac   1762

 atggctgcac atttattgcc tcttctgtca ttgagagcaa gaaaaagaat gcacagatca   1822

 tgatcatcca ctggggaaag agtaagctca ctttaactca gattcctgga cgtgctcggg   1882

 gcccaggccc tctgattgag aaacactgcc ccatgccggc cacccaagag gtcacccaca   1942

 tgccaggtac tgcagacatc atagctgtca tgcatgagga cgttgatggc tacaacattc   2002

 cactggtttt cccatgggtc cagttccaat atttctttgg agataacctc atggcgatct   2062

 ga                                                                  2064




      <210> 585
      <211> 6132
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (1)..(6132)

      <400> 585
  atg gcg gcg cgg ggc cgg ggg ctg ctg ctg ctg acg ctg tcg gtg ctg      48
  Met Ala Ala Arg Gly Arg Gly Leu Leu Leu Leu Thr Leu Ser Val Leu
    1               5                  10                  15

 ttg gcg gcg ggc ccc tcc gcc gct gcg gcc aag ctc aac atc ccc aaa       96
 Leu Ala Ala Gly Pro Ser Ala Ala Ala Ala Lys Leu Asn Ile Pro Lys
              20                  25                  30

 gtg ctg ctg ccc ttc acg cgg gcc acg cgc gtt aac ttc acg ctg gag      144
 Val Leu Leu Pro Phe Thr Arg Ala Thr Arg Val Asn Phe Thr Leu Glu
          35                  40                  45

 gcc tcg gag ggc tgc tac cgc tgg ttg tcc acc cgg ccg gag gtg gcc      192
 Ala Ser Glu Gly Cys Tyr Arg Trp Leu Ser Thr Arg Pro Glu Val Ala
      50                  55                  60

 agc atc gag ccg ctg ggc ctg gac gag cag cag tgc tcc cag aag gca      240
 Ser Ile Glu Pro Leu Gly Leu Asp Glu Gln Gln Cys Ser Gln Lys Ala
  65                  70                  75                  80

 gtg gtg cag gcc cgc ctg acc cag cct gcc cgc ctc acc agc atc atc      288
 Val Val Gln Ala Arg Leu Thr Gln Pro Ala Arg Leu Thr Ser Ile Ile
                  85                  90                  95

 ttc gca gag gac atc acc aca ggc cag gtc ctg cgc tgt gat gcc att      336
 Phe Ala Glu Asp Ile Thr Thr Gly Gln Val Leu Arg Cys Asp Ala Ile
             100                 105                 110

 gtg gac ctc atc cat gac atc cag atc gtc tcc acc acc cgc gag ctc      384
 Val Asp Leu Ile His Asp Ile Gln Ile Val Ser Thr Thr Arg Glu Leu
         115                 120                 125

 tac ctg gag gac tcc ccc ctg gag ctg aag atc cag gcc ctg gac tcc      432
 Tyr Leu Glu Asp Ser Pro Leu Glu Leu Lys Ile Gln Ala Leu Asp Ser
     130                 135                 140

 gaa ggg aac acc ttc agc act ctg gct gga ctg gtc ttc gag tgg acg      480
 Glu Gly Asn Thr Phe Ser Thr Leu Ala Gly Leu Val Phe Glu Trp Thr
 145                 150                 155                 160

 att gtg aag gac tcc gag gcg gac agg ttc tca gac tcc cac aat gcg      528
 Ile Val Lys Asp Ser Glu Ala Asp Arg Phe Ser Asp Ser His Asn Ala
                 165                 170                 175

 ctg cga atc ctc act ttc ttg gag tct acg tac atc cct cct tct tac      576
 Leu Arg Ile Leu Thr Phe Leu Glu Ser Thr Tyr Ile Pro Pro Ser Tyr
             180                 185                 190

 atc tca gag atg gag aag gct gcc aag caa ggg gac acc atc ctg gtg      624
 Ile Ser Glu Met Glu Lys Ala Ala Lys Gln Gly Asp Thr Ile Leu Val
         195                 200                 205

 tct ggg atg aag acc ggg agc tcc aag ctc aag gct cgc atc cag gag      672
 Ser Gly Met Lys Thr Gly Ser Ser Lys Leu Lys Ala Arg Ile Gln Glu
     210                 215                 220

 gct gtc tac aag aat gta cgc cct gca gaa gtc agg ctg ctg att ttg      720
 Ala Val Tyr Lys Asn Val Arg Pro Ala Glu Val Arg Leu Leu Ile Leu
 225                 230                 235                 240

 gaa aac atc ctt ctg aac ccg gcc tat gac gtc tac ctg atg gtg gga      768
 Glu Asn Ile Leu Leu Asn Pro Ala Tyr Asp Val Tyr Leu Met Val Gly
                 245                 250                 255

 acc tcc att cac tac aag gtg cag aag atc agg caa ggg aaa att aca      816
 Thr Ser Ile His Tyr Lys Val Gln Lys Ile Arg Gln Gly Lys Ile Thr
             260                 265                 270

 ggt att cgc atg caa ggt gct tct agg tta ccc aac agc act atc tac      864
 Gly Ile Arg Met Gln Gly Ala Ser Arg Leu Pro Asn Ser Thr Ile Tyr
         275                 280                 285

 gtg gtc gaa cct gga tac cta ggg ttc act gtt cac cct ggt gac agg      912
 Val Val Glu Pro Gly Tyr Leu Gly Phe Thr Val His Pro Gly Asp Arg
     290                 295                 300

 tgg gtg ctg gag acc ggc cgc ctg tat gaa atc acc atc gaa gtt ttt      960
 Trp Val Leu Glu Thr Gly Arg Leu Tyr Glu Ile Thr Ile Glu Val Phe
 305                 310                 315                 320

 gac aag ttc agc aac aag gtc tat gta tct gac aac atc cga att gaa     1008
 Asp Lys Phe Ser Asn Lys Val Tyr Val Ser Asp Asn Ile Arg Ile Glu
                 325                 330                 335

 act gtg ctt cct gct gag ttc ttc gag gtg ctc tcg tcc tcc cag aat     1056
 Thr Val Leu Pro Ala Glu Phe Phe Glu Val Leu Ser Ser Ser Gln Asn
             340                 345                 350

 ggg tca tac cat cgc atc agg gca cta aag agg gga cag acg gcc att     1104
 Gly Ser Tyr His Arg Ile Arg Ala Leu Lys Arg Gly Gln Thr Ala Ile
         355                 360                 365

 gac gcg gcc ctc acc tct gtg gtg gac cag gca atc ttt aag aag ccc     1152
 Asp Ala Ala Leu Thr Ser Val Val Asp Gln Ala Ile Phe Lys Lys Pro
     370                 375                 380

 atc agc ctt agg gag cag agc ttt gct gat tgg aaa atc ggc ctg ggt     1200
 Ile Ser Leu Arg Glu Gln Ser Phe Ala Asp Trp Lys Ile Gly Leu Gly
 385                 390                 395                 400

 gtt ccc att ttc cta ccc cgc aca gaa ggc ctc ctg gcc tgg aag ggg     1248
 Val Pro Ile Phe Leu Pro Arg Thr Glu Gly Leu Leu Ala Trp Lys Gly
                 405                 410                 415

 cag cag gct gat gga ggg gtc cac ata cta cag gtg cct gtg tgg aac     1296
 Gln Gln Ala Asp Gly Gly Val His Ile Leu Gln Val Pro Val Trp Asn
             420                 425                 430

 cag cag gag gtg gaa att cac atc ccg atc acc ctg tat ccc agc atc     1344
 Gln Gln Glu Val Glu Ile His Ile Pro Ile Thr Leu Tyr Pro Ser Ile
         435                 440                 445

 ttg aca ttt ccg tgg caa cca aag acg ggc gcc tat cag tac aca ata     1392
 Leu Thr Phe Pro Trp Gln Pro Lys Thr Gly Ala Tyr Gln Tyr Thr Ile
     450                 455                 460

 agg gcc cac ggt ggc agt ggg aac ttc agc tgg tct tcg tca agc cac     1440
 Arg Ala His Gly Gly Ser Gly Asn Phe Ser Trp Ser Ser Ser Ser His
 465                 470                 475                 480

 ctg gtt gcc aca gtt act gtc aag ggc gtg atg acc aca ggc agt gac     1488
 Leu Val Ala Thr Val Thr Val Lys Gly Val Met Thr Thr Gly Ser Asp
                 485                 490                 495

 atc ggg ttc agt gtg atc cag gca cat gat gtg cag aac cca ctc cat     1536
 Ile Gly Phe Ser Val Ile Gln Ala His Asp Val Gln Asn Pro Leu His
             500                 505                 510

 ttc ggt gag atg aag gtg tat gtg atc gag ccc cac agc atg gag ttt     1584
 Phe Gly Glu Met Lys Val Tyr Val Ile Glu Pro His Ser Met Glu Phe
         515                 520                 525

 gcc ccg tgc cag gtg gag gca cgt gtg ggc cag gcc ctg gag ctg ccc     1632
 Ala Pro Cys Gln Val Glu Ala Arg Val Gly Gln Ala Leu Glu Leu Pro
     530                 535                 540

 ctg agg atc agt ggc ctc atg ccc ggc ggg gcc agt gag gtg gtc acc     1680
 Leu Arg Ile Ser Gly Leu Met Pro Gly Gly Ala Ser Glu Val Val Thr
 545                 550                 555                 560

 ttg agc gac tgc tcc cac ttt gac ttg gct gtc gag gtg gag aac cag     1728
 Leu Ser Asp Cys Ser His Phe Asp Leu Ala Val Glu Val Glu Asn Gln
                 565                 570                 575

 ggt gtg ttc cag cca ctc cca gga tgg ctg cga tca aaa caa cag aaa     1776
 Gly Val Phe Gln Pro Leu Pro Gly Trp Leu Arg Ser Lys Gln Gln Lys
             580                 585                 590

 aca gca aat gtt gac aag gat gtg aag aca ctg gaa ctc tta tgt gct     1824
 Thr Ala Asn Val Asp Lys Asp Val Lys Thr Leu Glu Leu Leu Cys Ala
         595                 600                 605

 gct ggt gtg tat gtg aaa ggt gct gct gct gtg gaa agc agg agg ctg     1872
 Ala Gly Val Tyr Val Lys Gly Ala Ala Ala Val Glu Ser Arg Arg Leu
     610                 615                 620

 ccg cca ggc tct gag cac tgc agc ggc atc cgg gta aag gcc gag gcc     1920
 Pro Pro Gly Ser Glu His Cys Ser Gly Ile Arg Val Lys Ala Glu Ala
 625                 630                 635                 640

 cag ggc tct acc acg ctt ctt gtg agc tac aga cac ggc cac gtc cac     1968
 Gln Gly Ser Thr Thr Leu Leu Val Ser Tyr Arg His Gly His Val His
                 645                 650                 655

 ctg agt gcc aag atc acc att gct gcc tac ctg ccc ctc aag atc atg     2016
 Leu Ser Ala Lys Ile Thr Ile Ala Ala Tyr Leu Pro Leu Lys Ile Met
             660                 665                 670

 cca cag aca gag aag gaa aca gac aca ccg tac cct cca caa gcc tat     2064
 Pro Gln Thr Glu Lys Glu Thr Asp Thr Pro Tyr Pro Pro Gln Ala Tyr
         675                 680                 685

 agc atg atc agg gag acc tct cag gcc atg aag ctc ctt cag ggt gag     2112
 Ser Met Ile Arg Glu Thr Ser Gln Ala Met Lys Leu Leu Gln Gly Glu
     690                 695                 700

 gag cac cag gct gtg gat ccc tcc tct gtt gcc ttg gta acc ctg ggc     2160
 Glu His Gln Ala Val Asp Pro Ser Ser Val Ala Leu Val Thr Leu Gly
 705                 710                 715                 720

 tcc tca aag gag atg ctg ttt gaa gga ggt ccc aga cct tgg atc ctc     2208
 Ser Ser Lys Glu Met Leu Phe Glu Gly Gly Pro Arg Pro Trp Ile Leu
                 725                 730                 735

 gag ccg tcc aaa ttc ttc cag aac gtc acc gct gag gac act gac agc     2256
 Glu Pro Ser Lys Phe Phe Gln Asn Val Thr Ala Glu Asp Thr Asp Ser
             740                 745                 750

 atc ggc ctg gct ctc ttt gcc ccc cat tcc tcc cgg aat tat cag caa     2304
 Ile Gly Leu Ala Leu Phe Ala Pro His Ser Ser Arg Asn Tyr Gln Gln
         755                 760                 765

 cac tgg atc ctt gtg acc tgt cag gcc ttg ggt gag cag gtc atc gcc     2352
 His Trp Ile Leu Val Thr Cys Gln Ala Leu Gly Glu Gln Val Ile Ala
     770                 775                 780

 ctg tcg gtg ggg aac aag ccc agc ctc acc aac ccc ttt cct gcg gtg     2400
 Leu Ser Val Gly Asn Lys Pro Ser Leu Thr Asn Pro Phe Pro Ala Val
 785                 790                 795                 800

 gag cct gcc gtg gtg aag ttc gtc tgc gcc cca ccg tcc agg ctc acc     2448
 Glu Pro Ala Val Val Lys Phe Val Cys Ala Pro Pro Ser Arg Leu Thr
                 805                 810                 815

 ctc gcg cct gtc tac acc agc ccc cag ctg gac atg tcc tgt ccg ctg     2496
 Leu Ala Pro Val Tyr Thr Ser Pro Gln Leu Asp Met Ser Cys Pro Leu
             820                 825                 830

 ctg cag cag aac aag cag gtg gtg agt gtg ggc tat gct cgg gag gag     2544
 Leu Gln Gln Asn Lys Gln Val Val Ser Val Gly Tyr Ala Arg Glu Glu
         835                 840                 845

 gag gac att ggt ggc ctc gcc cat ggt ccc gag cat tgc aac gga cat     2592
 Glu Asp Ile Gly Gly Leu Ala His Gly Pro Glu His Cys Asn Gly His
     850                 855                 860

 agc tcc acg ctg cac ttc ctt cgt ctc aac aac tgg ccc tgt gag gac     2640
 Ser Ser Thr Leu His Phe Leu Arg Leu Asn Asn Trp Pro Cys Glu Asp
 865                 870                 875                 880

 gct ggt ttc att tgt gtt tta tat gca ggg gac aca cag ctt gga gag     2688
 Ala Gly Phe Ile Cys Val Leu Tyr Ala Gly Asp Thr Gln Leu Gly Glu
                 885                 890                 895

 gtc cca gtg tcc agc cac cgc aac ccc cgg ctg gac ctg gct gct tac     2736
 Val Pro Val Ser Ser His Arg Asn Pro Arg Leu Asp Leu Ala Ala Tyr
             900                 905                 910

 gac cag gag ggc cgc cgg ttc gac aac ttc agc tct ctg agc atc cag     2784
 Asp Gln Glu Gly Arg Arg Phe Asp Asn Phe Ser Ser Leu Ser Ile Gln
         915                 920                 925

 tgg gag tcc acc agg cca gtg ttg gcc agc atc gag cct gag ctg ccc     2832
 Trp Glu Ser Thr Arg Pro Val Leu Ala Ser Ile Glu Pro Glu Leu Pro
     930                 935                 940

 atg cag ctg gtg tcc cag gac gat gag agt ggc caa aag aag ctg cac     2880
 Met Gln Leu Val Ser Gln Asp Asp Glu Ser Gly Gln Lys Lys Leu His
 945                 950                 955                 960

 ggt gag ctg ggc aca agc ctg atg gcc cag gca gga gaa cag aga cca     2928
 Gly Glu Leu Gly Thr Ser Leu Met Ala Gln Ala Gly Glu Gln Arg Pro
                 965                 970                 975

 gac agg aag cct gcc aag cat gac cct ctg gtg cct ctg tcg gcc tcc     2976
 Asp Arg Lys Pro Ala Lys His Asp Pro Leu Val Pro Leu Ser Ala Ser
             980                 985                 990

 ata gag ctc atc ctg gtg gag gac gtg agg gtg agc cca gaa gag gtg     3024
 Ile Glu Leu Ile Leu Val Glu Asp Val Arg Val Ser Pro Glu Glu Val
         995                1000                1005

 acc atc tac aac cac cct ggc atc cag gca gag ctc cgc atc agg gaa     3072
 Thr Ile Tyr Asn His Pro Gly Ile Gln Ala Glu Leu Arg Ile Arg Glu
    1010                1015                1020

 ggc tca ggt tac ttc ttc ctc aac acc agc acc gca gat gtt gtc aag     3120
 Gly Ser Gly Tyr Phe Phe Leu Asn Thr Ser Thr Ala Asp Val Val Lys
1025                1030                1035                1040

 gtg gcc tac cag gag gcc agg ggt gtc gcc atg gtg cac cct ttg ctc     3168
 Val Ala Tyr Gln Glu Ala Arg Gly Val Ala Met Val His Pro Leu Leu
                1045                1050                1055

 ccg ggc tca tcc acc atc atg atc cat gac ttg tgc ctc gtc ttc ccg     3216
 Pro Gly Ser Ser Thr Ile Met Ile His Asp Leu Cys Leu Val Phe Pro
            1060                1065                1070

 gcc cca gcc aag gct gtc gtt tac gtg tcg gac att cag gag ctg tac     3264
 Ala Pro Ala Lys Ala Val Val Tyr Val Ser Asp Ile Gln Glu Leu Tyr
        1075                1080                1085

 atc cgt gtg gtt gac aag gtg gag att ggg aag aca gtg aag gca tac     3312
 Ile Arg Val Val Asp Lys Val Glu Ile Gly Lys Thr Val Lys Ala Tyr
    1090                1095                1100

 gtc cgc gtg ctg gac ttg cac aag aag ccc ttc ctt gcc aaa tac ttc     3360
 Val Arg Val Leu Asp Leu His Lys Lys Pro Phe Leu Ala Lys Tyr Phe
1105                1110                1115                1120

 ccc ttt atg gac ctg aag ctc cga gca gcc tcc ccg atc att aca ttg     3408
 Pro Phe Met Asp Leu Lys Leu Arg Ala Ala Ser Pro Ile Ile Thr Leu
                1125                1130                1135

 gtg gcc ctt gat gaa gcc ctt gac aac tac acc atc aca ttc ctc atc     3456
 Val Ala Leu Asp Glu Ala Leu Asp Asn Tyr Thr Ile Thr Phe Leu Ile
            1140                1145                1150

 cgc ggt gtg gcc atc ggc cag acc agt cta act gca agt gtg acc aat     3504
 Arg Gly Val Ala Ile Gly Gln Thr Ser Leu Thr Ala Ser Val Thr Asn
        1155                1160                1165

 aaa gct gga cag aga atc aac tca gcc cca caa cag att gaa gtc ttt     3552
 Lys Ala Gly Gln Arg Ile Asn Ser Ala Pro Gln Gln Ile Glu Val Phe
    1170                1175                1180

 ccc ccg ttc agg ctg atg ccc agg aag gtg aca ctg ctt atc ggg gcc     3600
 Pro Pro Phe Arg Leu Met Pro Arg Lys Val Thr Leu Leu Ile Gly Ala
1185                1190                1195                1200

 acg atg cag gtc acc tcc gag ggc ggc ccc cag cct cag tcc aac atc     3648
 Thr Met Gln Val Thr Ser Glu Gly Gly Pro Gln Pro Gln Ser Asn Ile
                1205                1210                1215

 ctt ttc tcc atc agc aat gag agc gtt gcg ctg gtg agc gct gct ggg     3696
 Leu Phe Ser Ile Ser Asn Glu Ser Val Ala Leu Val Ser Ala Ala Gly
            1220                1225                1230

 ctg gta cag ggc ctc gcc atc ggg aac ggc act gtg tct ggg ctc gtg     3744
 Leu Val Gln Gly Leu Ala Ile Gly Asn Gly Thr Val Ser Gly Leu Val
        1235                1240                1245

 cag gca gtg gat gca gag acc ggc aag gtg gtc atc atc tct cag gac     3792
 Gln Ala Val Asp Ala Glu Thr Gly Lys Val Val Ile Ile Ser Gln Asp
    1250                1255                1260

 ctc gtg cag gtg gag gtg ctg ctg cta agg gcc gtg agg atc cgc gcc     3840
 Leu Val Gln Val Glu Val Leu Leu Leu Arg Ala Val Arg Ile Arg Ala
1265                1270                1275                1280

 ccc atc atg cgg atg agg acg ggc acc cag atg ccc atc tat gtc acc     3888
 Pro Ile Met Arg Met Arg Thr Gly Thr Gln Met Pro Ile Tyr Val Thr
                1285                1290                1295

 ggc atc acc aac cac cag aac cct ttc tcc ttt ggc aat gcc gtg cca     3936
 Gly Ile Thr Asn His Gln Asn Pro Phe Ser Phe Gly Asn Ala Val Pro
            1300                1305                1310

 ggc ctg acc ttc cac tgg tct gtc acc aag cgg gac gtc ctg gac ctc     3984
 Gly Leu Thr Phe His Trp Ser Val Thr Lys Arg Asp Val Leu Asp Leu
        1315                1320                1325

 cga ggg cgg cac cac gag tac aac ttt gcc atg aac gtg ctc ggc cgg     4032
 Arg Gly Arg His His Glu Tyr Asn Phe Ala Met Asn Val Leu Gly Arg
    1330                1335                1340

 gta aaa ggc cgg acc ggg ctg agg gtg gtg gtc aag gct gtg gac ccc     4080
 Val Lys Gly Arg Thr Gly Leu Arg Val Val Val Lys Ala Val Asp Pro
1345                1350                1355                1360

 aca tcg ggg cag ctg tat ggc ctg gcc aga gaa ctc tcg gat gag atc     4128
 Thr Ser Gly Gln Leu Tyr Gly Leu Ala Arg Glu Leu Ser Asp Glu Ile
                1365                1370                1375

 caa gtc cag gtg ttt gag aag ctg cag ctg ctc aac cct gaa ata gaa     4176
 Gln Val Gln Val Phe Glu Lys Leu Gln Leu Leu Asn Pro Glu Ile Glu
            1380                1385                1390

 gca gaa caa ata tta atg tcg ccc aac tca tat ata aag ctg cag aca     4224
 Ala Glu Gln Ile Leu Met Ser Pro Asn Ser Tyr Ile Lys Leu Gln Thr
        1395                1400                1405

 aac agg gat ggt gca gcc tct ctg agc tac cgc gtc ctg gat gga ccc     4272
 Asn Arg Asp Gly Ala Ala Ser Leu Ser Tyr Arg Val Leu Asp Gly Pro
    1410                1415                1420

 gaa aag gtt cca gtt gtg cat gtt gat gag aaa ggc ttt cta gca tca     4320
 Glu Lys Val Pro Val Val His Val Asp Glu Lys Gly Phe Leu Ala Ser
1425                1430                1435                1440

 ggg tct atg atc ggg aca tcc acc atc gaa gtg att gca caa gag ccc     4368
 Gly Ser Met Ile Gly Thr Ser Thr Ile Glu Val Ile Ala Gln Glu Pro
                1445                1450                1455

 ttt ggg gcc aac caa acc atc att gtt gct gta aag gta tcc cct gtt     4416
 Phe Gly Ala Asn Gln Thr Ile Ile Val Ala Val Lys Val Ser Pro Val
            1460                1465                1470

 tcc tac ctg agg gtt tcc atg agc cct gtc ctg cac acc cag aac aag     4464
 Ser Tyr Leu Arg Val Ser Met Ser Pro Val Leu His Thr Gln Asn Lys
        1475                1480                1485

 gag gcc ctg gtg gcc gtg cct ttg gga atg acc gtg acc ttc act gtc     4512
 Glu Ala Leu Val Ala Val Pro Leu Gly Met Thr Val Thr Phe Thr Val
    1490                1495                1500

 cac ttc cac gac aac tct gga gat gtc ttc cat gct cac agt tcg gtc     4560
 His Phe His Asp Asn Ser Gly Asp Val Phe His Ala His Ser Ser Val
1505                1510                1515                1520

 ctc aac ttt gcc act aac aga gac gac ttt gtg cag atc ggg aag ggc     4608
 Leu Asn Phe Ala Thr Asn Arg Asp Asp Phe Val Gln Ile Gly Lys Gly
                1525                1530                1535

 ccc acc aac aac acc tgc gtt gtc cgc aca gtc agc gtg ggc ctg aca     4656
 Pro Thr Asn Asn Thr Cys Val Val Arg Thr Val Ser Val Gly Leu Thr
            1540                1545                1550

 ctg ctc cgt gtg tgg gac gca gag cac ccg ggc ctc tcg gac ttc atg     4704
 Leu Leu Arg Val Trp Asp Ala Glu His Pro Gly Leu Ser Asp Phe Met
        1555                1560                1565

 ccc ctg cct gtc cta cag gcc atc tcc cca gag ctg tct ggg gcc atg     4752
 Pro Leu Pro Val Leu Gln Ala Ile Ser Pro Glu Leu Ser Gly Ala Met
    1570                1575                1580

 gtg gtg ggg gac gtg ctc tgt ctg gcc act gtt ctg acc agc ctg gaa     4800
 Val Val Gly Asp Val Leu Cys Leu Ala Thr Val Leu Thr Ser Leu Glu
1585                1590                1595                1600

 ggc ctc tca gga acc tgg agc tcc tca gcc aac agc atc ctc cac atc     4848
 Gly Leu Ser Gly Thr Trp Ser Ser Ser Ala Asn Ser Ile Leu His Ile
                1605                1610                1615

 gac ccc aag acg ggt gtg gct gtg gcc cgg gcc gtg gga tcc gtg acg     4896
 Asp Pro Lys Thr Gly Val Ala Val Ala Arg Ala Val Gly Ser Val Thr
            1620                1625                1630

 gtt tac tat gag gtc gct ggg cac ctg agg acc tac aag gag gtg gtg     4944
 Val Tyr Tyr Glu Val Ala Gly His Leu Arg Thr Tyr Lys Glu Val Val
        1635                1640                1645

 gtc agc gtc cct cag agg atc atg gcc cgt cac ctc cac ccc atc cag     4992
 Val Ser Val Pro Gln Arg Ile Met Ala Arg His Leu His Pro Ile Gln
    1650                1655                1660

 acc agc ttc cag gag gct aca gcc tcc aaa gtg att gtt gcc gtg gga     5040
 Thr Ser Phe Gln Glu Ala Thr Ala Ser Lys Val Ile Val Ala Val Gly
1665                1670                1675                1680

 gac aga agc tct aac ctg aga ggc gag tgc acc ccc acc cag agg gaa     5088
 Asp Arg Ser Ser Asn Leu Arg Gly Glu Cys Thr Pro Thr Gln Arg Glu
                1685                1690                1695

 gtc atc cag gcc ttg cac cca gag acc ctc atc agc tgc cag tcc cag     5136
 Val Ile Gln Ala Leu His Pro Glu Thr Leu Ile Ser Cys Gln Ser Gln
            1700                1705                1710

 ttc aag ccg gcc gtc ttt gat ttc cca tct caa gat gtg ttc acc gtg     5184
 Phe Lys Pro Ala Val Phe Asp Phe Pro Ser Gln Asp Val Phe Thr Val
        1715                1720                1725

 gag cca cag ttt gac act gct ctc ggc cag tac ttc tgc tca atc aca     5232
 Glu Pro Gln Phe Asp Thr Ala Leu Gly Gln Tyr Phe Cys Ser Ile Thr
    1730                1735                1740

 atg cac agg ctg acg gac aag cag cgg aag cac ctg agc atg aag aag     5280
 Met His Arg Leu Thr Asp Lys Gln Arg Lys His Leu Ser Met Lys Lys
1745                1750                1755                1760

 aca gct ctg gtg gtc agt gcc tcc ctc tcc agc agc cac ttc tcc aca     5328
 Thr Ala Leu Val Val Ser Ala Ser Leu Ser Ser Ser His Phe Ser Thr
                1765                1770                1775

 gag cag gtg ggg gcc gag gtg ccc ttc agc cca ggt ctc ttc gcc gac     5376
 Glu Gln Val Gly Ala Glu Val Pro Phe Ser Pro Gly Leu Phe Ala Asp
            1780                1785                1790

 cag gct gaa atc ctt ttg agc aac cac tac acc agt tcc gag atc agg     5424
 Gln Ala Glu Ile Leu Leu Ser Asn His Tyr Thr Ser Ser Glu Ile Arg
        1795                1800                1805

 gtc ttt ggt gcc ccg gag gtt ctg gag aac ttg gag gtg aaa tcc ggg     5472
 Val Phe Gly Ala Pro Glu Val Leu Glu Asn Leu Glu Val Lys Ser Gly
    1810                1815                1820

 tcc ccg gcc gtg ctg gca ttc gca aag gag aag tct ttt ggg tgg ccc     5520
 Ser Pro Ala Val Leu Ala Phe Ala Lys Glu Lys Ser Phe Gly Trp Pro
1825                1830                1835                1840

 agc ttc atc aca tac acg gtc ggc gtc ttg gac ccc gcg gct ggc agc     5568
 Ser Phe Ile Thr Tyr Thr Val Gly Val Leu Asp Pro Ala Ala Gly Ser
                1845                1850                1855

 caa ggg cct ctg tcc act acc ctg acc ttc tcc agc ccc gtg acc aac     5616
 Gln Gly Pro Leu Ser Thr Thr Leu Thr Phe Ser Ser Pro Val Thr Asn
            1860                1865                1870

 caa gcc att gcc atc cca gtg aca gtg gct ttt gtg gtg gat cgc cgt     5664
 Gln Ala Ile Ala Ile Pro Val Thr Val Ala Phe Val Val Asp Arg Arg
        1875                1880                1885

 ggg ccc ggt cct tat gga gcc agc ctc ttc cag cac ttc ctg gat tcc     5712
 Gly Pro Gly Pro Tyr Gly Ala Ser Leu Phe Gln His Phe Leu Asp Ser
    1890                1895                1900

 tac cag gtc atg ttc ttc acg ctc ttc gcc ctg ttg gct ggg aca gcg     5760
 Tyr Gln Val Met Phe Phe Thr Leu Phe Ala Leu Leu Ala Gly Thr Ala
1905                1910                1915                1920

 gtc atg atc ata ggt gag gag gct gcc tgt atc tct ggg tct gtt ccc     5808
 Val Met Ile Ile Gly Glu Glu Ala Ala Cys Ile Ser Gly Ser Val Pro
                1925                1930                1935

 ctg ccc cga cct gct cta acc aac cct gtg ctc ttg cag cct acc aca     5856
 Leu Pro Arg Pro Ala Leu Thr Asn Pro Val Leu Leu Gln Pro Thr Thr
            1940                1945                1950

 ctg tct gca cgc ccc ggg atc ttg ctg tgc ctg cag ccc tca cgc ctc     5904
 Leu Ser Ala Arg Pro Gly Ile Leu Leu Cys Leu Gln Pro Ser Arg Leu
        1955                1960                1965

 gag cca gcc ctg gac aca gcc ccc act aag ctg gac ttc atc aaa agc     5952
 Glu Pro Ala Leu Asp Thr Ala Pro Thr Lys Leu Asp Phe Ile Lys Ser
    1970                1975                1980

 cta tct gag act ctc tgc ctc tta ata gtt gac aat cat ggt gac cac     6000
 Leu Ser Glu Thr Leu Cys Leu Leu Ile Val Asp Asn His Gly Asp His
1985                1990                1995                2000

 aaa ggg act cag act aga ctg ccc atg gtc atc tgg aac gct gtg ggc     6048
 Lys Gly Thr Gln Thr Arg Leu Pro Met Val Ile Trp Asn Ala Val Gly
                2005                2010                2015

 atg cag cac cct ggt acc agc aca ggc cct gtg agc gtc tct gct tcc     6096
 Met Gln His Pro Gly Thr Ser Thr Gly Pro Val Ser Val Ser Ala Ser
            2020                2025                2030

 gcc atg gtt gca gac aac tgg atg agt ctc tcc tga                     6132
 Ala Met Val Ala Asp Asn Trp Met Ser Leu Ser 
        2035                2040





      <210> 586
      <211> 378
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (1)..(378)

      <400> 586
  atg gac atg agg gtc ctc gct cag ctc ctg ggg ctc ctg ctg ctc tgt      48
  Met Asp Met Arg Val Leu Ala Gln Leu Leu Gly Leu Leu Leu Leu Cys
    1               5                  10                  15

 ttc cca ggt gcc aga tgt gac atc cag atg acc cag tct cca tcc tca       96
 Phe Pro Gly Ala Arg Cys Asp Ile Gln Met Thr Gln Ser Pro Ser Ser
              20                  25                  30

 ctg tct gca tct gta gga gac aga gtc acc atc act tgt cgg gcg agt      144
 Leu Ser Ala Ser Val Gly Asp Arg Val Thr Ile Thr Cys Arg Ala Ser
          35                  40                  45

 cag ggt att agc agc tgg tta gcc tgg tat cag cag aaa cca gag aaa      192
 Gln Gly Ile Ser Ser Trp Leu Ala Trp Tyr Gln Gln Lys Pro Glu Lys
      50                  55                  60

 gcc cct aag tcc ctg atc tat gct gca tcc agt ttg caa agt ggg gtc      240
 Ala Pro Lys Ser Leu Ile Tyr Ala Ala Ser Ser Leu Gln Ser Gly Val
  65                  70                  75                  80

 cca tca agg ttc agc ggc agt gga tct ggg aca gat ttc act ctc acc      288
 Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr
                  85                  90                  95

 atc agc agc ctg cag cct gaa gat ttt gca act tat tac tgc caa cag      336
 Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln
             100                 105                 110

 tat aat agt tac cct ccc aca gtg tta cac acc caa aca taa              378
 Tyr Asn Ser Tyr Pro Pro Thr Val Leu His Thr Gln Thr 
         115                 120                 125





      <210> 587
      <211> 1119
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (1)..(1119)

      <400> 587
  atg ctc ttc acc gtc cct gct gtc ccc acg tgc cta gcc ctg gtg tgg      48
  Met Leu Phe Thr Val Pro Ala Val Pro Thr Cys Leu Ala Leu Val Trp
    1               5                  10                  15

 gca gga atg agt ggg att ggg atg ttt tct cac agg tct ttc tca gga       96
 Ala Gly Met Ser Gly Ile Gly Met Phe Ser His Arg Ser Phe Ser Gly
              20                  25                  30

 cat gga cca agt tgg gat tta ggg ttg ctc ttg ggt tac cag cca gcg      144
 His Gly Pro Ser Trp Asp Leu Gly Leu Leu Leu Gly Tyr Gln Pro Ala
          35                  40                  45

 tcc ctg aag ccc ctc cca aaa tgt cac tgg ggc cct gtg acc ata gaa      192
 Ser Leu Lys Pro Leu Pro Lys Cys His Trp Gly Pro Val Thr Ile Glu
      50                  55                  60

 gag gcc tct gtg ggc cac aca gta aga tca act gct aaa acc aac aat      240
 Glu Ala Ser Val Gly His Thr Val Arg Ser Thr Ala Lys Thr Asn Asn
  65                  70                  75                  80

 gcc ttg aca tcc ttc tac atg aat cca cat ctt cct aac atc tat ttt      288
 Ala Leu Thr Ser Phe Tyr Met Asn Pro His Leu Pro Asn Ile Tyr Phe
                  85                  90                  95

 gga atg ctc agg tcc ctc agg agt cag aag agc agg gac act ggg gtc      336
 Gly Met Leu Arg Ser Leu Arg Ser Gln Lys Ser Arg Asp Thr Gly Val
             100                 105                 110

 cgt atg cca ctt cag acc act gta tgt gga gcc gag atg tca gag ctg      384
 Arg Met Pro Leu Gln Thr Thr Val Cys Gly Ala Glu Met Ser Glu Leu
         115                 120                 125

 gag cag aga aga gga gca cgc aga ttg aaa ttc agc ctg ccc cac ttc      432
 Glu Gln Arg Arg Gly Ala Arg Arg Leu Lys Phe Ser Leu Pro His Phe
     130                 135                 140

 tca gga aga tgc cac gag gct gat ccc cct gag cag ttt gtc ctg tcc      480
 Ser Gly Arg Cys His Glu Ala Asp Pro Pro Glu Gln Phe Val Leu Ser
 145                 150                 155                 160

 tct ttt cac tgg ttt tct tcc tca tta cct ggg cta gaa aac atg gtg      528
 Ser Phe His Trp Phe Ser Ser Ser Leu Pro Gly Leu Glu Asn Met Val
                 165                 170                 175

 gaa gct aaa ggc ttg cag caa agc tgg gct ccc acg atc ggg aat gag      576
 Glu Ala Lys Gly Leu Gln Gln Ser Trp Ala Pro Thr Ile Gly Asn Glu
             180                 185                 190

 gac act atg aag aaa gtg agt cct gca aat cac cgc ata cct cta agt      624
 Asp Thr Met Lys Lys Val Ser Pro Ala Asn His Arg Ile Pro Leu Ser
         195                 200                 205

 gat gga aac agc att ccc atc atc aga ctt ggt acc tac tca gag cct      672
 Asp Gly Asn Ser Ile Pro Ile Ile Arg Leu Gly Thr Tyr Ser Glu Pro
     210                 215                 220

 aaa ttg acc cct aag ggg gcc aat gac tta ctc aag gcc aca cag caa      720
 Lys Leu Thr Pro Lys Gly Ala Asn Asp Leu Leu Lys Ala Thr Gln Gln
 225                 230                 235                 240

 gta ggt gca ggc cag ctg gag ctc atc cag aac aac cca gga ctc aaa      768
 Val Gly Ala Gly Gln Leu Glu Leu Ile Gln Asn Asn Pro Gly Leu Lys
                 245                 250                 255

 ccc aag cca gtc agc aac gag gtt gag tgc cac cca tat tac acc caa      816
 Pro Lys Pro Val Ser Asn Glu Val Glu Cys His Pro Tyr Tyr Thr Gln
             260                 265                 270

 cca aaa ctt ttg aaa ttt cgc caa caa cat gac att gtc atg att gca      864
 Pro Lys Leu Leu Lys Phe Arg Gln Gln His Asp Ile Val Met Ile Ala
         275                 280                 285

 tat agc cct ttg ggg acc act agg aat cca acc tgg aca aat atg tct      912
 Tyr Ser Pro Leu Gly Thr Thr Arg Asn Pro Thr Trp Thr Asn Met Ser
     290                 295                 300

 tct ctg cct tcg tta aag gat gca ctt cta aaa agg tgc aat aag atc      960
 Ser Leu Pro Ser Leu Lys Asp Ala Leu Leu Lys Arg Cys Asn Lys Ile
 305                 310                 315                 320

 aca gct caa gtt att ttg cgt ttc aac atc cag caa ggg gtg gtt gtc     1008
 Thr Ala Gln Val Ile Leu Arg Phe Asn Ile Gln Gln Gly Val Val Val
                 325                 330                 335

 att cct aaa agc ttt aat cct gaa aag atc aag gaa aac ctt cag gcc     1056
 Ile Pro Lys Ser Phe Asn Pro Glu Lys Ile Lys Glu Asn Leu Gln Ala
             340                 345                 350

 ttt gac ttt tct ctc act gaa tca agg aca ttg aag cct gga gtg aaa     1104
 Phe Asp Phe Ser Leu Thr Glu Ser Arg Thr Leu Lys Pro Gly Val Lys
         355                 360                 365

 atg tcc gct tca tag                                                 1119
 Met Ser Ala Ser 
     370





      <210> 588
      <211> 1881
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (1)..(1881)

      <400> 588
  atg ctg gaa gat tgt cag gtt tcc ctc tgg gta aga ctc aca tgg tgc      48
  Met Leu Glu Asp Cys Gln Val Ser Leu Trp Val Arg Leu Thr Trp Cys
    1               5                  10                  15

 cag ctg gcc tct ctg aca aga gct ctc cga act tct gct atc agt gag       96
 Gln Leu Ala Ser Leu Thr Arg Ala Leu Arg Thr Ser Ala Ile Ser Glu
              20                  25                  30

 gcc gca tta ctg gaa atg aca cgg tgg aag act cgg gcc aca gag aaa      144
 Ala Ala Leu Leu Glu Met Thr Arg Trp Lys Thr Arg Ala Thr Glu Lys
          35                  40                  45

 ctg atc acc tgg ccc cag atc cca gaa caa ggt gct gtg aaa gga agc      192
 Leu Ile Thr Trp Pro Gln Ile Pro Glu Gln Gly Ala Val Lys Gly Ser
      50                  55                  60

 acc atc acc cct ctt tcc tca ttt cca acg gtg cag ggg gca tgg gtc      240
 Thr Ile Thr Pro Leu Ser Ser Phe Pro Thr Val Gln Gly Ala Trp Val
  65                  70                  75                  80

 ctc tca caa caa gta gga att atg gga gct aca att caa gat gag att      288
 Leu Ser Gln Gln Val Gly Ile Met Gly Ala Thr Ile Gln Asp Glu Ile
                  85                  90                  95

 tgg gtg ggg aca cag aac cga acc tta tta act agt gtc atg aga aca      336
 Trp Val Gly Thr Gln Asn Arg Thr Leu Leu Thr Ser Val Met Arg Thr
             100                 105                 110

 gga aga ggc gcc aga ggc tgc ctg ttc tcc ctt tct ctc tct ctg tgc      384
 Gly Arg Gly Ala Arg Gly Cys Leu Phe Ser Leu Ser Leu Ser Leu Cys
         115                 120                 125

 atg cac aga gaa gag gcc aag caa gct caa agt gaa aag gca ctg tct      432
 Met His Arg Glu Glu Ala Lys Gln Ala Gln Ser Glu Lys Ala Leu Ser
     130                 135                 140

 ata agc agg aag aga ggc ctc agc aga aac ggt tgc tcc aaa tgt cta      480
 Ile Ser Arg Lys Arg Gly Leu Ser Arg Asn Gly Cys Ser Lys Cys Leu
 145                 150                 155                 160

 aac agt aat gtc atc atc agt caa aca act aca agc aaa cat caa gca      528
 Asn Ser Asn Val Ile Ile Ser Gln Thr Thr Thr Ser Lys His Gln Ala
                 165                 170                 175

 gat cca gtg aat cct aca gat ggg gtc aga gga ctc ctt ccc aaa gaa      576
 Asp Pro Val Asn Pro Thr Asp Gly Val Arg Gly Leu Leu Pro Lys Glu
             180                 185                 190

 gct ggg gga aca cat gaa aaa tcc cat gac gct gaa ttc gac agc cac      624
 Ala Gly Gly Thr His Glu Lys Ser His Asp Ala Glu Phe Asp Ser His
         195                 200                 205

 cta caa acc ata aaa cat gga agg atg tcc ctg tgt ggc cct gtg tgc      672
 Leu Gln Thr Ile Lys His Gly Arg Met Ser Leu Cys Gly Pro Val Cys
     210                 215                 220

 act gcc ttg gtc act ggg aaa gac aat gaa gtt tct aat tat cca aca      720
 Thr Ala Leu Val Thr Gly Lys Asp Asn Glu Val Ser Asn Tyr Pro Thr
 225                 230                 235                 240

 gat atg aat gct gac cat tac att tgt acc tta att aca ggg aag gtt      768
 Asp Met Asn Ala Asp His Tyr Ile Cys Thr Leu Ile Thr Gly Lys Val
                 245                 250                 255

 att gtt tac agt tct gat aag tgg ctg ttt tac tca gtg tgc aaa ggg      816
 Ile Val Tyr Ser Ser Asp Lys Trp Leu Phe Tyr Ser Val Cys Lys Gly
             260                 265                 270

 ctt tcc gtt tat cct cct ggc ttt tct agg cat cta att aca ctg ttg      864
 Leu Ser Val Tyr Pro Pro Gly Phe Ser Arg His Leu Ile Thr Leu Leu
         275                 280                 285

 ggg aca tgg atg ccc agc cta gaa gtt gat ccc aac tgc ttc tgc cct      912
 Gly Thr Trp Met Pro Ser Leu Glu Val Asp Pro Asn Cys Phe Cys Pro
     290                 295                 300

 acg cac agc cag tct ctc cag gct gta tta gtc cat ttc cac act gct      960
 Thr His Ser Gln Ser Leu Gln Ala Val Leu Val His Phe His Thr Ala
 305                 310                 315                 320

 gat aaa gac ata cct gag act ggg cag ttt aca aaa gaa aga ggt tta     1008
 Asp Lys Asp Ile Pro Glu Thr Gly Gln Phe Thr Lys Glu Arg Gly Leu
                 325                 330                 335

 att gga ctt aca gtt ccg tat ggt tgg gga aac ctc aca atc atg gtg     1056
 Ile Gly Leu Thr Val Pro Tyr Gly Trp Gly Asn Leu Thr Ile Met Val
             340                 345                 350

 gaa ggc aag gaa gag caa gtc cca ttt tac atg gat ggc agc agg caa     1104
 Glu Gly Lys Glu Glu Gln Val Pro Phe Tyr Met Asp Gly Ser Arg Gln
         355                 360                 365

 aga gag aat gag gaa gat gca aaa gcg gaa acc cat gat caa acc atc     1152
 Arg Glu Asn Glu Glu Asp Ala Lys Ala Glu Thr His Asp Gln Thr Ile
     370                 375                 380

 aga cct cgt gag att cat tca cta cca gga gaa cag tat ggg gga aac     1200
 Arg Pro Arg Glu Ile His Ser Leu Pro Gly Glu Gln Tyr Gly Gly Asn
 385                 390                 395                 400

 cgc ccc cat gat tca att agc tcc cac cag gtc ctt ccc aca aca cac     1248
 Arg Pro His Asp Ser Ile Ser Ser His Gln Val Leu Pro Thr Thr His
                 405                 410                 415

 tgg aat cat ggg agt aca gtt caa gat gag att tgg gtg ggg aca cag     1296
 Trp Asn His Gly Ser Thr Val Gln Asp Glu Ile Trp Val Gly Thr Gln
             420                 425                 430

 cca aac cct atc aca ggc tct gtc ggt tct gtc tcc tca atg ttt ctt     1344
 Pro Asn Pro Ile Thr Gly Ser Val Gly Ser Val Ser Ser Met Phe Leu
         435                 440                 445

 ggc ttc gtg ccc ttt tca cat ctc cat gag aac agt ctc agc cac ccc     1392
 Gly Phe Val Pro Phe Ser His Leu His Glu Asn Ser Leu Ser His Pro
     450                 455                 460

 acc ttc tgt agg ccc aca cag act gcc tgg tca ctc tgg ggt ctt cac     1440
 Thr Phe Cys Arg Pro Thr Gln Thr Ala Trp Ser Leu Trp Gly Leu His
 465                 470                 475                 480

 acc ctg tct ccc cag tac agc cct ggc aac ctt acc tgc aac tgc aag     1488
 Thr Leu Ser Pro Gln Tyr Ser Pro Gly Asn Leu Thr Cys Asn Cys Lys
                 485                 490                 495

 caa ggc aca tct cca aca ggg aga cag tgg gac atc tgt gtg tcc att     1536
 Gln Gly Thr Ser Pro Thr Gly Arg Gln Trp Asp Ile Cys Val Ser Ile
             500                 505                 510

 gct aca gcc aga agg att ctc aaa aca gag cct gga act gaa gat gct     1584
 Ala Thr Ala Arg Arg Ile Leu Lys Thr Glu Pro Gly Thr Glu Asp Ala
         515                 520                 525

 tgg gaa gga cct gtt gaa atg gga ttg gag act ggc ctg ggc aaa aaa     1632
 Trp Glu Gly Pro Val Glu Met Gly Leu Glu Thr Gly Leu Gly Lys Lys
     530                 535                 540

 gca aga cct cat ctc caa gaa gaa gat gaa aga gag caa gag aag aag     1680
 Ala Arg Pro His Leu Gln Glu Glu Asp Glu Arg Glu Gln Glu Lys Lys
 545                 550                 555                 560

 agg aag aag aag aag aag aag aag aag aag aag aag aag aag aag aag     1728
 Arg Lys Lys Lys Lys Lys Lys Lys Lys Lys Lys Lys Lys Lys Lys Lys
                 565                 570                 575

 aag aag aag aag aag aag aag cag cag gag aag gag aag gag aag gag     1776
 Lys Lys Lys Lys Lys Lys Lys Gln Gln Glu Lys Glu Lys Glu Lys Glu
             580                 585                 590

 aag gag aag gag aag gag aag ggg agg aag ggg aag gga agg ggg aag     1824
 Lys Glu Lys Glu Lys Glu Lys Gly Arg Lys Gly Lys Gly Arg Gly Lys
         595                 600                 605

 gag gag gag aag aag aag aag gag aaa aag acg gag gag gag gag aag     1872
 Glu Glu Glu Lys Lys Lys Lys Glu Lys Lys Thr Glu Glu Glu Glu Lys
     610                 615                 620

 aaa aag taa                                                         1881
 Lys Lys 
 625





      <210> 589
      <211> 2517
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (1)..(2517)

      <400> 589
  atg ggg ccc ttc ttg ctc aat gcg gtg cgc tgg ctg gcc aga ggc cag      48
  Met Gly Pro Phe Leu Leu Asn Ala Val Arg Trp Leu Ala Arg Gly Gln
    1               5                  10                  15

 aca ggc aaa gtt ggg gtg aac aca aat cta aaa gat ctg tgt cct ctc       96
 Thr Gly Lys Val Gly Val Asn Thr Asn Leu Lys Asp Leu Cys Pro Leu
              20                  25                  30

 cta tcg gag cat ggc ctg caa tgc agc ctg gag ccc cat ctg aac agc      144
 Leu Ser Glu His Gly Leu Gln Cys Ser Leu Glu Pro His Leu Asn Ser
          35                  40                  45

 gac ttg tgt gtc tac tgc tgc aag gca tac agt gac aag gag gct aag      192
 Asp Leu Cys Val Tyr Cys Cys Lys Ala Tyr Ser Asp Lys Glu Ala Lys
      50                  55                  60

 cag ctg cag gag ttt gtg gct gag ggt ggg ggg ctg ctg att ggg ggc      240
 Gln Leu Gln Glu Phe Val Ala Glu Gly Gly Gly Leu Leu Ile Gly Gly
  65                  70                  75                  80

 cag gcc tgg tgg tgg gcc tcc cag aac cct ggc cac tgc ccc ttg gct      288
 Gln Ala Trp Trp Trp Ala Ser Gln Asn Pro Gly His Cys Pro Leu Ala
                  85                  90                  95

 ggc ttc cct ggt aac atc atc ctc aac tgc ttt ggc ctc agc atc ctg      336
 Gly Phe Pro Gly Asn Ile Ile Leu Asn Cys Phe Gly Leu Ser Ile Leu
             100                 105                 110

 cct cag act ctc aaa gca ggc tgc ttc ccc gtt ccc acc cct gag atg      384
 Pro Gln Thr Leu Lys Ala Gly Cys Phe Pro Val Pro Thr Pro Glu Met
         115                 120                 125

 aga agc tac cac ttc cgc aag gcg ctc tct caa ttc cag gct ata ctg      432
 Arg Ser Tyr His Phe Arg Lys Ala Leu Ser Gln Phe Gln Ala Ile Leu
     130                 135                 140

 aac cac gag aat ggg aac ttg gaa aag agc tgt ctg gca aag ttg aga      480
 Asn His Glu Asn Gly Asn Leu Glu Lys Ser Cys Leu Ala Lys Leu Arg
 145                 150                 155                 160

 gtt gat ggt gca gcc ttc cta cag att cct gcg gag ggg gtc cct gct      528
 Val Asp Gly Ala Ala Phe Leu Gln Ile Pro Ala Glu Gly Val Pro Ala
                 165                 170                 175

 tac ata tcc ctg cac agg ctc ctg agg aag atg cta cga ggg tct ggc      576
 Tyr Ile Ser Leu His Arg Leu Leu Arg Lys Met Leu Arg Gly Ser Gly
             180                 185                 190

 ctc cca gct gtg agc cgg gaa aat cca gtt gcc agt gac tcc tat gag      624
 Leu Pro Ala Val Ser Arg Glu Asn Pro Val Ala Ser Asp Ser Tyr Glu
         195                 200                 205

 gct gcg gtg ctc tcc ctg gcc act ggg ctg gct cac tct gga act gac      672
 Ala Ala Val Leu Ser Leu Ala Thr Gly Leu Ala His Ser Gly Thr Asp
     210                 215                 220

 tgc tcc cag ctg gcc cag ggg ctt ggc acc tgg acc tgc tcc tcc agt      720
 Cys Ser Gln Leu Ala Gln Gly Leu Gly Thr Trp Thr Cys Ser Ser Ser
 225                 230                 235                 240

 ttg tac ccc tca aaa cac ccc atc acc gtg gag atc aat gga atc aac      768
 Leu Tyr Pro Ser Lys His Pro Ile Thr Val Glu Ile Asn Gly Ile Asn
                 245                 250                 255

 cca ggc aac aat gat tgc tgg gtg agt acc ggg ctc tac ctc ctg gaa      816
 Pro Gly Asn Asn Asp Cys Trp Val Ser Thr Gly Leu Tyr Leu Leu Glu
             260                 265                 270

 gga caa aat gca gaa gtc tca ctg tct gaa gct gct gcc tct gct ggc      864
 Gly Gln Asn Ala Glu Val Ser Leu Ser Glu Ala Ala Ala Ser Ala Gly
         275                 280                 285

 ctg agg gta cag ata ggc tgc cac acc gat gac ctt acc aag gcc agg      912
 Leu Arg Val Gln Ile Gly Cys His Thr Asp Asp Leu Thr Lys Ala Arg
     290                 295                 300

 aag cta tct cga gcc ccc gtg gtg act cac caa tgc tgg atg gac agg      960
 Lys Leu Ser Arg Ala Pro Val Val Thr His Gln Cys Trp Met Asp Arg
 305                 310                 315                 320

 act gag cgg tca gtc tcc tgc ctc tgg ggc ggc ctc ctc tac gtc atc     1008
 Thr Glu Arg Ser Val Ser Cys Leu Trp Gly Gly Leu Leu Tyr Val Ile
                 325                 330                 335

 gtg ccc aag ggc agc caa cta ggc cct gtg cct gtc act atc agg gga     1056
 Val Pro Lys Gly Ser Gln Leu Gly Pro Val Pro Val Thr Ile Arg Gly
             340                 345                 350

 gct gtg cct gcc cca tac tac aag ctg ggt aag aca tcg ctg gag gag     1104
 Ala Val Pro Ala Pro Tyr Tyr Lys Leu Gly Lys Thr Ser Leu Glu Glu
         355                 360                 365

 tgg aag agg cag atg cag gag aac ctg gct ccc tgg gga gag ctg gcc     1152
 Trp Lys Arg Gln Met Gln Glu Asn Leu Ala Pro Trp Gly Glu Leu Ala
     370                 375                 380

 acg gac aac atc atc ctg aca gtg cca acc aca aac ctt cag gcc ctg     1200
 Thr Asp Asn Ile Ile Leu Thr Val Pro Thr Thr Asn Leu Gln Ala Leu
 385                 390                 395                 400

 aag gac ccc gag cct gtg ctc cgc ctc tgg gat gag atg atg cag gct     1248
 Lys Asp Pro Glu Pro Val Leu Arg Leu Trp Asp Glu Met Met Gln Ala
                 405                 410                 415

 gtg gcc agg ctg gcg gct gag ccc ttc cct ttc cgc cgt cct gag agg     1296
 Val Ala Arg Leu Ala Ala Glu Pro Phe Pro Phe Arg Arg Pro Glu Arg
             420                 425                 430

 att gtg gct gat gtg cag atc tca gct ggc tgg atg cat tca gga tac     1344
 Ile Val Ala Asp Val Gln Ile Ser Ala Gly Trp Met His Ser Gly Tyr
         435                 440                 445

 ccc atc atg tgc cac ctg gag tct gtg aag gag atc atc aat gag atg     1392
 Pro Ile Met Cys His Leu Glu Ser Val Lys Glu Ile Ile Asn Glu Met
     450                 455                 460

 gac atg agg agc agg ggt gtg tgg ggc ccc atc cat gag ctg ggc cac     1440
 Asp Met Arg Ser Arg Gly Val Trp Gly Pro Ile His Glu Leu Gly His
 465                 470                 475                 480

 aac caa cag tgg cat gga tgg gag ttc ccc cca cac act act gag gcc     1488
 Asn Gln Gln Trp His Gly Trp Glu Phe Pro Pro His Thr Thr Glu Ala
                 485                 490                 495

 acc tgt aac ctt tgg tca gtc tac gtg cat gaa aca gtc ctg ggg atc     1536
 Thr Cys Asn Leu Trp Ser Val Tyr Val His Glu Thr Val Leu Gly Ile
             500                 505                 510

 ccc agg gct cag gcc cat gag gct ctg agc cct cca gag cga gag agg     1584
 Pro Arg Ala Gln Ala His Glu Ala Leu Ser Pro Pro Glu Arg Glu Arg
         515                 520                 525

 aga atc aag gcc cac ctg gga aag gga gcc ccc ctg tgt gac tgg aat     1632
 Arg Ile Lys Ala His Leu Gly Lys Gly Ala Pro Leu Cys Asp Trp Asn
     530                 535                 540

 gta tgg aca gcc ctg gaa aca tat cta cag ctc caa cag gcc ttc ggg     1680
 Val Trp Thr Ala Leu Glu Thr Tyr Leu Gln Leu Gln Gln Ala Phe Gly
 545                 550                 555                 560

 tgg gag cca ttc acc cag ctc ttt gct gag tac cag acc ctc tct cac     1728
 Trp Glu Pro Phe Thr Gln Leu Phe Ala Glu Tyr Gln Thr Leu Ser His
                 565                 570                 575

 ctc ccc aaa gac aac act ggc agg atg aat cta tgg gtg aag aag ttc     1776
 Leu Pro Lys Asp Asn Thr Gly Arg Met Asn Leu Trp Val Lys Lys Phe
             580                 585                 590

 tct gaa aaa gtg aag aag aat ctg gtt ccc ttc ttt gag gcc tgg ggc     1824
 Ser Glu Lys Val Lys Lys Asn Leu Val Pro Phe Phe Glu Ala Trp Gly
         595                 600                 605

 tgg cct atc cag aag gag gtg gct gac agc ctg gcc tcc cta cca gag     1872
 Trp Pro Ile Gln Lys Glu Val Ala Asp Ser Leu Ala Ser Leu Pro Glu
     610                 615                 620

 tgg cag gaa aac ccc atg caa gtg tac ctc cgt gcc agg aag tat atc     1920
 Trp Gln Glu Asn Pro Met Gln Val Tyr Leu Arg Ala Arg Lys Tyr Ile
 625                 630                 635                 640

 ttg tgc aaa gga agc ttt aca gga tgc aaa ggt gcg aac aat act gtg     1968
 Leu Cys Lys Gly Ser Phe Thr Gly Cys Lys Gly Ala Asn Asn Thr Val
                 645                 650                 655

 ttt aag aaa gga aaa gca tgt gtt act tca gag ctg gaa gtg cag ggg     2016
 Phe Lys Lys Gly Lys Ala Cys Val Thr Ser Glu Leu Glu Val Gln Gly
             660                 665                 670

 aag cca ctg agg act aaa gga aag gga tgg gat ggt atg gtt agg aaa     2064
 Lys Pro Leu Arg Thr Lys Gly Lys Gly Trp Asp Gly Met Val Arg Lys
         675                 680                 685

 tgt tcg caa acc aca tct gag cag aca ggt gca caa ggc agc cct gaa     2112
 Cys Ser Gln Thr Thr Ser Glu Gln Thr Gly Ala Gln Gly Ser Pro Glu
     690                 695                 700

 gta gcg gat gta ttc tca tcc aca atc gtc ctc tac aag aac tct aac     2160
 Val Ala Asp Val Phe Ser Ser Thr Ile Val Leu Tyr Lys Asn Ser Asn
 705                 710                 715                 720

 aag aac cgt tac att tcg tcc act ctc tct aag gtg aaa ctt gca gag     2208
 Lys Asn Arg Tyr Ile Ser Ser Thr Leu Ser Lys Val Lys Leu Ala Glu
                 725                 730                 735

 cgc ctc agc ctg gct tct cca ggg tct ggc atg cca gtg att act gga     2256
 Arg Leu Ser Leu Ala Ser Pro Gly Ser Gly Met Pro Val Ile Thr Gly
             740                 745                 750

 cgt ttt tcc tgc tac ttt ctt cca cta aat ctc tcc aag ctc gga aag     2304
 Arg Phe Ser Cys Tyr Phe Leu Pro Leu Asn Leu Ser Lys Leu Gly Lys
         755                 760                 765

 ttc ctt gac ccc cac ttc act cac ggg ttc aaa gca gta gac act tgc     2352
 Phe Leu Asp Pro His Phe Thr His Gly Phe Lys Ala Val Asp Thr Cys
     770                 775                 780

 atc act ggt cag att ggg ctc gat gct ggt gtc tat gcc ccc cac tgc     2400
 Ile Thr Gly Gln Ile Gly Leu Asp Ala Gly Val Tyr Ala Pro His Cys
 785                 790                 795                 800

 gag gag gcc act cag ggt tct cag ctc tgt ctg cac cac aat ctt gcc     2448
 Glu Glu Ala Thr Gln Gly Ser Gln Leu Cys Leu His His Asn Leu Ala
                 805                 810                 815

 tct gcg gcc ccc atc cag cca gcg gac agc att gag cag aaa ggg gcc     2496
 Ser Ala Ala Pro Ile Gln Pro Ala Asp Ser Ile Glu Gln Lys Gly Ala
             820                 825                 830

 cag ttt acc aac agt gaa taa                                         2517
 Gln Phe Thr Asn Ser Glu 
         835





      <210> 590
      <211> 414
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (1)..(414)

      <400> 590
  atg acg gtg gta atg gtg gtg atg acg gtg gtg gtg atg gta atc aga      48
  Met Thr Val Val Met Val Val Met Thr Val Val Val Met Val Ile Arg
    1               5                  10                  15

 aaa aaa act att gta aaa ttc ata tgg aac caa aaa aga gcc aaa ata       96
 Lys Lys Thr Ile Val Lys Phe Ile Trp Asn Gln Lys Arg Ala Lys Ile
              20                  25                  30

 gcc aaa gca atc cta agc aaa aag aac aaa gcc aaa ggc atc aca tta      144
 Ala Lys Ala Ile Leu Ser Lys Lys Asn Lys Ala Lys Gly Ile Thr Leu
          35                  40                  45

 ttc aac ttc aaa cta tac tac aag gct aat gta acc aaa aca acg tcc      192
 Phe Asn Phe Lys Leu Tyr Tyr Lys Ala Asn Val Thr Lys Thr Thr Ser
      50                  55                  60

 agt cat cag act tgg cag cat tca ttc att cga aac act gct tac aga      240
 Ser His Gln Thr Trp Gln His Ser Phe Ile Arg Asn Thr Ala Tyr Arg
  65                  70                  75                  80

 cac gtg gct cca gcc tct gcc tct gtc atc acc tgg ctt tct ccc tgt      288
 His Val Ala Pro Ala Ser Ala Ser Val Ile Thr Trp Leu Ser Pro Cys
                  85                  90                  95

 gtc tgc atc ctc tcc tct tct tac aag aac cca gtc atg gaa atc agg      336
 Val Cys Ile Leu Ser Ser Ser Tyr Lys Asn Pro Val Met Glu Ile Arg
             100                 105                 110

 ccc aat cta atc cag cat gac ctc atc tct gtc atc att cca aat aag      384
 Pro Asn Leu Ile Gln His Asp Leu Ile Ser Val Ile Ile Pro Asn Lys
         115                 120                 125

 gtc aca ttc agg ggt ttc agg tgg aca tga                              414
 Val Thr Phe Arg Gly Phe Arg Trp Thr 
     130                 135





      <210> 591
      <211> 849
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (1)..(849)

      <400> 591
  atg tgc ctc tcc aag tct ggg ctt tta gaa gcc ttg tat gtt ttt tct      48
  Met Cys Leu Ser Lys Ser Gly Leu Leu Glu Ala Leu Tyr Val Phe Ser
    1               5                  10                  15

 tgt cct ctt atg cca ctg ctg ctt cat gga gca tgg gaa gaa tgt gcc       96
 Cys Pro Leu Met Pro Leu Leu Leu His Gly Ala Trp Glu Glu Cys Ala
              20                  25                  30

 cca atc atc ttg cta gtg caa gga gga gga gag atg tac caa gcg aaa      144
 Pro Ile Ile Leu Leu Val Gln Gly Gly Gly Glu Met Tyr Gln Ala Lys
          35                  40                  45

 ata agt ggg aaa aaa tta ttt aaa ata ctc aaa gtg gaa aag ccc aat      192
 Ile Ser Gly Lys Lys Leu Phe Lys Ile Leu Lys Val Glu Lys Pro Asn
      50                  55                  60

 cca cag aag ctt caa gtt aga aca agc aca gcc cag gga aac ctc ctc      240
 Pro Gln Lys Leu Gln Val Arg Thr Ser Thr Ala Gln Gly Asn Leu Leu
  65                  70                  75                  80

 aca gtt ttc atc cag cca cgg gcc agc atg tct ggg ggc aaa tac gta      288
 Thr Val Phe Ile Gln Pro Arg Ala Ser Met Ser Gly Gly Lys Tyr Val
                  85                  90                  95

 gac tcg gag gga cat ctc tac acc gtt ccc atc cgg gaa cag ggc aac      336
 Asp Ser Glu Gly His Leu Tyr Thr Val Pro Ile Arg Glu Gln Gly Asn
             100                 105                 110

 atc tac aag ccc aac aac aag gcc atg gca gac gag ctg agc gag aag      384
 Ile Tyr Lys Pro Asn Asn Lys Ala Met Ala Asp Glu Leu Ser Glu Lys
         115                 120                 125

 caa gtg tac gac gcg cac acc aag gag atc gac ctg gtc aac cgc gac      432
 Gln Val Tyr Asp Ala His Thr Lys Glu Ile Asp Leu Val Asn Arg Asp
     130                 135                 140

 cct aaa cac ctc aac gat gac gtg gtc aag aag tgg ttt ctc ata gat      480
 Pro Lys His Leu Asn Asp Asp Val Val Lys Lys Trp Phe Leu Ile Asp
 145                 150                 155                 160

 ctc aga tct ctt ttc agg aaa aag aaa aac aac aac aat aac aac aca      528
 Leu Arg Ser Leu Phe Arg Lys Lys Lys Asn Asn Asn Asn Asn Asn Thr
                 165                 170                 175

 tta atg act ctg aaa gag tca gac acc att aat tcc att att ggt gtc      576
 Leu Met Thr Leu Lys Glu Ser Asp Thr Ile Asn Ser Ile Ile Gly Val
             180                 185                 190

 tgt gcc aat gtc act tgt ttg gta aca ctc aac atc aac atg tgc tac      624
 Cys Ala Asn Val Thr Cys Leu Val Thr Leu Asn Ile Asn Met Cys Tyr
         195                 200                 205

 caa att gac acc aga gga caa aaa aga atc aag ata tgt aca gcc tgc      672
 Gln Ile Asp Thr Arg Gly Gln Lys Arg Ile Lys Ile Cys Thr Ala Cys
     210                 215                 220

 ttt gta ctg agc cag ctg cca cta gat gtt ttt tgt gat aat gaa cac      720
 Phe Val Leu Ser Gln Leu Pro Leu Asp Val Phe Cys Asp Asn Glu His
 225                 230                 235                 240

 gaa aag aat ctc aag gca gac ctg ctt cgg gtc tgc tct gta aag agt      768
 Glu Lys Asn Leu Lys Ala Asp Leu Leu Arg Val Cys Ser Val Lys Ser
                 245                 250                 255

 gtg cat acg gtt gtc aaa ctc atc ttg ata aac tac tgc atc gat tgt      816
 Val His Thr Val Val Lys Leu Ile Leu Ile Asn Tyr Cys Ile Asp Cys
             260                 265                 270

 ggc tac act ccc ctg ctc cca cat ctt cca tag                          849
 Gly Tyr Thr Pro Leu Leu Pro His Leu Pro 
         275                 280





      <210> 592
      <211> 1824
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (1)..(1824)

      <400> 592
  atg ttg ctc agg ctg gtc tgg gct cag gcc cag gga gat cca aat tct      48
  Met Leu Leu Arg Leu Val Trp Ala Gln Ala Gln Gly Asp Pro Asn Ser
    1               5                  10                  15

 gtc cct gag gct ctg gct gga gtt att gga gat cct gca gga aag ccc       96
 Val Pro Glu Ala Leu Ala Gly Val Ile Gly Asp Pro Ala Gly Lys Pro
              20                  25                  30

 cgc cca ctg agg aag gat ggg tca gaa tta ggc ctg aag atg cac tct      144
 Arg Pro Leu Arg Lys Asp Gly Ser Glu Leu Gly Leu Lys Met His Ser
          35                  40                  45

 gac cgc agg cca gct gcc ccc gtc ccc gtc ccc cat ccc cgt cgt ccc      192
 Asp Arg Arg Pro Ala Ala Pro Val Pro Val Pro His Pro Arg Arg Pro
      50                  55                  60

 cag tcc cca ccc ccg tac ccc gga ccc cca ccc ccg tcc ccc ccc acc      240
 Gln Ser Pro Pro Pro Tyr Pro Gly Pro Pro Pro Pro Ser Pro Pro Thr
  65                  70                  75                  80

 aat gta cca ccc cca cac cac cag tgt aat tct tat tct tac ttc ttt      288
 Asn Val Pro Pro Pro His His Gln Cys Asn Ser Tyr Ser Tyr Phe Phe
                  85                  90                  95

 ata gcc cta gca aat gac tac act gat cct cac ctg aca cta cct tct      336
 Ile Ala Leu Ala Asn Asp Tyr Thr Asp Pro His Leu Thr Leu Pro Ser
             100                 105                 110

 gtt aat tgt tct ttg gct tca agc act gaa gcc aaa ggc agg atg ccg      384
 Val Asn Cys Ser Leu Ala Ser Ser Thr Glu Ala Lys Gly Arg Met Pro
         115                 120                 125

 cta ccc tat gga aac aca gca gaa aaa caa cac acg ctc ctt acc ctt      432
 Leu Pro Tyr Gly Asn Thr Ala Glu Lys Gln His Thr Leu Leu Thr Leu
     130                 135                 140

 cac ttt tca gga gaa gta aac tgg ata gcc acc ccg acc tgg agc ctg      480
 His Phe Ser Gly Glu Val Asn Trp Ile Ala Thr Pro Thr Trp Ser Leu
 145                 150                 155                 160

 gag gtc aag gag agg cta gga gca gcg acc tat ggc gct ctg gga agg      528
 Glu Val Lys Glu Arg Leu Gly Ala Ala Thr Tyr Gly Ala Leu Gly Arg
                 165                 170                 175

 agc tcc cgg ctt gcc tat ggg tgc cct ggg gag agc atc act tct ggc      576
 Ser Ser Arg Leu Ala Tyr Gly Cys Pro Gly Glu Ser Ile Thr Ser Gly
             180                 185                 190

 tcg gag ggt ttc ggg agc gcc ttc tcc agc tca agc act cct ttt gtc      624
 Ser Glu Gly Phe Gly Ser Ala Phe Ser Ser Ser Ser Thr Pro Phe Val
         195                 200                 205

 gtt tat gag agg tgg gct ccc cga cct tgc gct tct aga gct gca gga      672
 Val Tyr Glu Arg Trp Ala Pro Arg Pro Cys Ala Ser Arg Ala Ala Gly
     210                 215                 220

 gcg gcg ctg cac agg tct gac aag ccc agc tca ttg gcg gcc agg ctg      720
 Ala Ala Leu His Arg Ser Asp Lys Pro Ser Ser Leu Ala Ala Arg Leu
 225                 230                 235                 240

 gac gca gaa ccg cac gga agc ctc ccc aac tcc tgc ctc tgg gag tgc      768
 Asp Ala Glu Pro His Gly Ser Leu Pro Asn Ser Cys Leu Trp Glu Cys
                 245                 250                 255

 tcc tgc ctg ctt caa gga atc tgg gca gcg gga ccc tct ggg ttt agc      816
 Ser Cys Leu Leu Gln Gly Ile Trp Ala Ala Gly Pro Ser Gly Phe Ser
             260                 265                 270

 gtc ctc gcc tgg gga agc aac ttt ggc ctt acc gta gaa gtt aca aaa      864
 Val Leu Ala Trp Gly Ser Asn Phe Gly Leu Thr Val Glu Val Thr Lys
         275                 280                 285

 ttg gcg ggg cgt ttg gtg ttg att cga gcg gga aga ggg ggg tgg gtg      912
 Leu Ala Gly Arg Leu Val Leu Ile Arg Ala Gly Arg Gly Gly Trp Val
     290                 295                 300

 gga tcg gtg ggg gag acc atg acc tcc agc tac ggg cac gtt ctg gag      960
 Gly Ser Val Gly Glu Thr Met Thr Ser Ser Tyr Gly His Val Leu Glu
 305                 310                 315                 320

 cgg caa ccg gcg ctg ggc ggc cgc ttg gac agc ccg ggc aac ctc gac     1008
 Arg Gln Pro Ala Leu Gly Gly Arg Leu Asp Ser Pro Gly Asn Leu Asp
                 325                 330                 335

 acc ctg cag gcg aaa aag aac ttc tcc gtc agt cac ctg cta gac ctg     1056
 Thr Leu Gln Ala Lys Lys Asn Phe Ser Val Ser His Leu Leu Asp Leu
             340                 345                 350

 gag gaa gcc ggg gac atg gtg gcg gca cag gcg gat gag aac gtg ggc     1104
 Glu Glu Ala Gly Asp Met Val Ala Ala Gln Ala Asp Glu Asn Val Gly
         355                 360                 365

 gag gct ggc cgg agc ctg ctg gag tcg ccg gga ctc acc agc ggc agc     1152
 Glu Ala Gly Arg Ser Leu Leu Glu Ser Pro Gly Leu Thr Ser Gly Ser
     370                 375                 380

 gac acc ccg cag cag gac aag agc cag cgc tgt ttg gga aag cag cag     1200
 Asp Thr Pro Gln Gln Asp Lys Ser Gln Arg Cys Leu Gly Lys Gln Gln
 385                 390                 395                 400

 gtt aaa gat gct gag tcg ggt tgg aag ggc ttc tct cgg gca gcg tat     1248
 Val Lys Asp Ala Glu Ser Gly Trp Lys Gly Phe Ser Arg Ala Ala Tyr
                 405                 410                 415

 gac ggc ttg agg gag ggc acc agg cac agg gag cag gac ttg gcg ctg     1296
 Asp Gly Leu Arg Glu Gly Thr Arg His Arg Glu Gln Asp Leu Ala Leu
             420                 425                 430

 ctc agg ctg cac tct cca cgc ggg cac cgt gac atg tgg cca gat atg     1344
 Leu Arg Leu His Ser Pro Arg Gly His Arg Asp Met Trp Pro Asp Met
         435                 440                 445

 tac aga tac tcc ctc ttc tcc tcg agg ttg caa gag tct gaa ctt agc     1392
 Tyr Arg Tyr Ser Leu Phe Ser Ser Arg Leu Gln Glu Ser Glu Leu Ser
     450                 455                 460

 tac tct caa aga ata gac ata caa atc aaa ctg cac ata gaa aca att     1440
 Tyr Ser Gln Arg Ile Asp Ile Gln Ile Lys Leu His Ile Glu Thr Ile
 465                 470                 475                 480

 gga aac agg gtc cgg gca cag tgg tgg ccc cgc ggg cca cgc tac agc     1488
 Gly Asn Arg Val Arg Ala Gln Trp Trp Pro Arg Gly Pro Arg Tyr Ser
                 485                 490                 495

 aag ccg cag aga gag cct ctg ata ctg cag ggg aag agg gat gaa aat     1536
 Lys Pro Gln Arg Glu Pro Leu Ile Leu Gln Gly Lys Arg Asp Glu Asn
             500                 505                 510

 tgt acc ggt tgt ttg gct ctg agt gga cgc cac tcc caa gaa ggg agc     1584
 Cys Thr Gly Cys Leu Ala Leu Ser Gly Arg His Ser Gln Glu Gly Ser
         515                 520                 525

 tcg gga ttc gtc gtg gcc tta gag tgg aat ttt ggg gaa att gat agt     1632
 Ser Gly Phe Val Val Ala Leu Glu Trp Asn Phe Gly Glu Ile Asp Ser
     530                 535                 540

 cca gtg act cct acc cac ttt tgg gtg aag gac gat ttg gaa ttt gaa     1680
 Pro Val Thr Pro Thr His Phe Trp Val Lys Asp Asp Leu Glu Phe Glu
 545                 550                 555                 560

 gtg tgg gga gac agg cct gtg aag tcc gaa gga ctc act ggg tct cca     1728
 Val Trp Gly Asp Arg Pro Val Lys Ser Glu Gly Leu Thr Gly Ser Pro
                 565                 570                 575

 gat ccc cca act ctg gaa tgc agt gaa tac cca ccc cca tgt ttc aga     1776
 Asp Pro Pro Thr Leu Glu Cys Ser Glu Tyr Pro Pro Pro Cys Phe Arg
             580                 585                 590

 gca tct ctc cca tgt gtt aga cgt cgt gca gtc ctg cat ttt ggc tga     1824
 Ala Ser Leu Pro Cys Val Arg Arg Arg Ala Val Leu His Phe Gly 
         595                 600                 605





      <210> 593
      <211> 1221
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (1)..(1221)

      <400> 593
  atg gcg cct ccc gtc cgt ctc gag cgt ccc ttt cct tcc cgg cgc ttt      48
  Met Ala Pro Pro Val Arg Leu Glu Arg Pro Phe Pro Ser Arg Arg Phe
    1               5                  10                  15

 cct ggg ttg ctt ctg gcg gcc ctg gtg ttg ctg ctg tcc tcc ttc tcc       96
 Pro Gly Leu Leu Leu Ala Ala Leu Val Leu Leu Leu Ser Ser Phe Ser
              20                  25                  30

 gag agc gag gcc agg gtt ctc cga ggg gtg ccg tgc tca gat ccc ggg      144
 Glu Ser Glu Ala Arg Val Leu Arg Gly Val Pro Cys Ser Asp Pro Gly
          35                  40                  45

 ggt atg tgg cgg ggg atg cgg gaa cca cgc aga agc ttg ttt ggt ggc      192
 Gly Met Trp Arg Gly Met Arg Glu Pro Arg Arg Ser Leu Phe Gly Gly
      50                  55                  60

 atc gtg tgc gcg gcc gac att tac gca gga tct ggc tgc gtt ccc aaa      240
 Ile Val Cys Ala Ala Asp Ile Tyr Ala Gly Ser Gly Cys Val Pro Lys
  65                  70                  75                  80

 aga agc gtg aat cgt gtt ttc ggg att gag ccc agt cag caa ggg gag      288
 Arg Ser Val Asn Arg Val Phe Gly Ile Glu Pro Ser Gln Gln Gly Glu
                  85                  90                  95

 ggc tta ctg ggc gcc cca ggt gag ggc ttg ctc tgg agt gca cag gtg      336
 Gly Leu Leu Gly Ala Pro Gly Glu Gly Leu Leu Trp Ser Ala Gln Val
             100                 105                 110

 cgt ggg att gtt gct aga gcc cgt gct gtg ccc gtg gtg aga gtt tgc      384
 Arg Gly Ile Val Ala Arg Ala Arg Ala Val Pro Val Val Arg Val Cys
         115                 120                 125

 cct gtg ttc cct tgg tgc ctt gtc ctg gaa cgt tct ccc cat gac ctg      432
 Pro Val Phe Pro Trp Cys Leu Val Leu Glu Arg Ser Pro His Asp Leu
     130                 135                 140

 ctg cat aaa tgg gct gtt tct tct gca agc tca gct gga atg tta ccg      480
 Leu His Lys Trp Ala Val Ser Ser Ala Ser Ser Ala Gly Met Leu Pro
 145                 150                 155                 160

 ctt cag aga cct tct tgg aac ccc cca act cag ggg gac ctg cag aat      528
 Leu Gln Arg Pro Ser Trp Asn Pro Pro Thr Gln Gly Asp Leu Gln Asn
                 165                 170                 175

 gga atc aca gga agt cct cct aca gac tca tca ggg ata tta cct tgg      576
 Gly Ile Thr Gly Ser Pro Pro Thr Asp Ser Ser Gly Ile Leu Pro Trp
             180                 185                 190

 tat gag cca gag gac aag ctg aaa acc aga gtg gtt tgc tct cct aaa      624
 Tyr Glu Pro Glu Asp Lys Leu Lys Thr Arg Val Val Cys Ser Pro Lys
         195                 200                 205

 agc caa gga gtg aga act ctt cag gca gaa gag aat gcc tat gag gag      672
 Ser Gln Gly Val Arg Thr Leu Gln Ala Glu Glu Asn Ala Tyr Glu Glu
     210                 215                 220

 cca cca aca ttt gaa gct atg gag ctc att ggt aaa cca aaa ccc tac      720
 Pro Pro Thr Phe Glu Ala Met Glu Leu Ile Gly Lys Pro Lys Pro Tyr
 225                 230                 235                 240

 tat gag att ggg gaa caa gta gat tat aag tgt aaa aaa gga cac ttc      768
 Tyr Glu Ile Gly Glu Gln Val Asp Tyr Lys Cys Lys Lys Gly His Phe
                 245                 250                 255

 tac gta cct cct ctt gcc acc cat act att tgt gat cgg aat cac aca      816
 Tyr Val Pro Pro Leu Ala Thr His Thr Ile Cys Asp Arg Asn His Thr
             260                 265                 270

 tgg cta cct gtc tca gat gag ccc tgt tat aga aaa aca tgt cca tgt      864
 Trp Leu Pro Val Ser Asp Glu Pro Cys Tyr Arg Lys Thr Cys Pro Cys
         275                 280                 285

 ata ggt gat cct tta cat ggc caa gca gtc ctt gca aat ggg act tat      912
 Ile Gly Asp Pro Leu His Gly Gln Ala Val Leu Ala Asn Gly Thr Tyr
     290                 295                 300

 gag cta ggt tat cag ata cac ttt att tgt aat gag ggt tat tac tta      960
 Glu Leu Gly Tyr Gln Ile His Phe Ile Cys Asn Glu Gly Tyr Tyr Leu
 305                 310                 315                 320

 att ggt aaa gaa att cta tat tgt gaa ctt aaa gga tca gta gca gtt     1008
 Ile Gly Lys Glu Ile Leu Tyr Cys Glu Leu Lys Gly Ser Val Ala Val
                 325                 330                 335

 tgg agc agt aag ccc cca ata tgt gaa aca ctg gca cca gga gcc ctg     1056
 Trp Ser Ser Lys Pro Pro Ile Cys Glu Thr Leu Ala Pro Gly Ala Leu
             340                 345                 350

 caa agc agc atc tgg gag atg gac agc cag ggg gaa aat aaa gga agc     1104
 Gln Ser Ser Ile Trp Glu Met Asp Ser Gln Gly Glu Asn Lys Gly Ser
         355                 360                 365

 ttt cag aag tgg cta gat gag ata ttt gaa ata ctg aaa act aaa aat     1152
 Phe Gln Lys Trp Leu Asp Glu Ile Phe Glu Ile Leu Lys Thr Lys Asn
     370                 375                 380

 ccc aac tgc atg gaa gag ctg gcc tca gat gtg gtc agt tct tac gac     1200
 Pro Asn Cys Met Glu Glu Leu Ala Ser Asp Val Val Ser Ser Tyr Asp
 385                 390                 395                 400

 aac ctg gac aca cag tgc tga                                         1221
 Asn Leu Asp Thr Gln Cys 
                 405





      <210> 594
      <211> 906
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (1)..(906)

      <400> 594
  atg gca tct tgc tat gtt cac tac gct gaa atg cag tgg ctc ttc aca      48
  Met Ala Ser Cys Tyr Val His Tyr Ala Glu Met Gln Trp Leu Phe Thr
    1               5                  10                  15

 ggc atg atc ttg gtg cac cac agc ctc aaa ctc ctg agc tca agc gat       96
 Gly Met Ile Leu Val His His Ser Leu Lys Leu Leu Ser Ser Ser Asp
              20                  25                  30

 gcc ctc acc tca gcc tcc caa ctg aag agt ctg ctg ctt ctg gag caa      144
 Ala Leu Thr Ser Ala Ser Gln Leu Lys Ser Leu Leu Leu Leu Glu Gln
          35                  40                  45

 agg gag atc tgg ctg cta gtg acc gat gtc act ctg caa acg aag gag      192
 Arg Glu Ile Trp Leu Leu Val Thr Asp Val Thr Leu Gln Thr Lys Glu
      50                  55                  60

 gag aga gac ccc agg ctc ccc aaa acc ctg ctg gtc tat gtg gcc ccc      240
 Glu Arg Asp Pro Arg Leu Pro Lys Thr Leu Leu Val Tyr Val Ala Pro
  65                  70                  75                  80

 ttg tgt gtg ctg ggc tct gaa gtc ctg gag gca ctc gct ggg gct gcc      288
 Leu Cys Val Leu Gly Ser Glu Val Leu Glu Ala Leu Ala Gly Ala Ala
                  85                  90                  95

 cct cac agc ctc ttc ttc aag gac gct ctc cgt gac cag ggt cgg att      336
 Pro His Ser Leu Phe Phe Lys Asp Ala Leu Arg Asp Gln Gly Arg Ile
             100                 105                 110

 gtt tgt gct gaa cga act gtc ctc ttg ctt cag aag ccc ctt ttg agt      384
 Val Cys Ala Glu Arg Thr Val Leu Leu Leu Gln Lys Pro Leu Leu Ser
         115                 120                 125

 gtg gtc tct ggt gca agt tcc tgt gag ctg cct ggc ccg gtg atg ctc      432
 Val Val Ser Gly Ala Ser Ser Cys Glu Leu Pro Gly Pro Val Met Leu
     130                 135                 140

 gac agc ctg gac tct gca aca cct gtc aac tcc atc tgc agt gtt caa      480
 Asp Ser Leu Asp Ser Ala Thr Pro Val Asn Ser Ile Cys Ser Val Gln
 145                 150                 155                 160

 ggc act gtg gtt ggc gtg gac gag agc act gct ttc tca tgg cct gtg      528
 Gly Thr Val Val Gly Val Asp Glu Ser Thr Ala Phe Ser Trp Pro Val
                 165                 170                 175

 tgt gac atg tgt ggc aac ggg aga ttg gaa cag agg ccg gaa gac agg      576
 Cys Asp Met Cys Gly Asn Gly Arg Leu Glu Gln Arg Pro Glu Asp Arg
             180                 185                 190

 cac ctg cag gtc ttc ctg gac tgc cgc tca aga ccg cag tgc aga gtg      624
 His Leu Gln Val Phe Leu Asp Cys Arg Ser Arg Pro Gln Cys Arg Val
         195                 200                 205

 aag gtc aag gta gga gcc agg cca gag cac gca cgc act cct agc tca      672
 Lys Val Lys Val Gly Ala Arg Pro Glu His Ala Arg Thr Pro Ser Ser
     210                 215                 220

 ctc caa cat agc gaa ggt gag aca gag ctg aag cag ctg ttg cag cgc      720
 Leu Gln His Ser Glu Gly Glu Thr Glu Leu Lys Gln Leu Leu Gln Arg
 225                 230                 235                 240

 agc att tcc tcc ctg ctg agg ttt gcc gcc ggt gaa gat ggg agc tac      768
 Ser Ile Ser Ser Leu Leu Arg Phe Ala Ala Gly Glu Asp Gly Ser Tyr
                 245                 250                 255

 gaa gtg aag agt gtc ctc gga aag gaa gtg ggg ttg tta aat tgt ttt      816
 Glu Val Lys Ser Val Leu Gly Lys Glu Val Gly Leu Leu Asn Cys Phe
             260                 265                 270

 gtc cag tcc gta acc gcc cac ccg acc agc tgc att gga ttg gag gaa      864
 Val Gln Ser Val Thr Ala His Pro Thr Ser Cys Ile Gly Leu Glu Glu
         275                 280                 285

 atc gag ctt ctg agt gca gga ggg gcc tct gca gaa cac tag              906
 Ile Glu Leu Leu Ser Ala Gly Gly Ala Ser Ala Glu His 
     290                 295                 300





      <210> 595
      <211> 1017
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (1)..(1017)

      <400> 595
  atg ggt tct gaa acc tac act ctg ctc ctc atg ctg ctg ttg gaa ccc      48
  Met Gly Ser Glu Thr Tyr Thr Leu Leu Leu Met Leu Leu Leu Glu Pro
    1               5                  10                  15

 cag ctt cca acc aaa aca gga aag cag gaa aga aag ggt aca ggt ttc       96
 Gln Leu Pro Thr Lys Thr Gly Lys Gln Glu Arg Lys Gly Thr Gly Phe
              20                  25                  30

 tat aag ttg ctg gag gga gtc cgg aaa ttg agg att cag ttc tct gag      144
 Tyr Lys Leu Leu Glu Gly Val Arg Lys Leu Arg Ile Gln Phe Ser Glu
          35                  40                  45

 atc gga ttc gag aca aat caa gat gag gtc cta aat gcc ctg gct gtt      192
 Ile Gly Phe Glu Thr Asn Gln Asp Glu Val Leu Asn Ala Leu Ala Val
      50                  55                  60

 caa tgc atc tat gac agt tat ctg aga tca gaa gca gct cac tgg agg      240
 Gln Cys Ile Tyr Asp Ser Tyr Leu Arg Ser Glu Ala Ala His Trp Arg
  65                  70                  75                  80

 tgc ttc cag gag aat atc aag aca aga ttt cac tat gta gac tgg ata      288
 Cys Phe Gln Glu Asn Ile Lys Thr Arg Phe His Tyr Val Asp Trp Ile
                  85                  90                  95

 aag aaa atg tgc tac ata tac acc atg gaa tac tat gca gcc att aaa      336
 Lys Lys Met Cys Tyr Ile Tyr Thr Met Glu Tyr Tyr Ala Ala Ile Lys
             100                 105                 110

 aag cac aaa atc gtg tct ttt gca gca aca tgg atg cat ctg aag gcc      384
 Lys His Lys Ile Val Ser Phe Ala Ala Thr Trp Met His Leu Lys Ala
         115                 120                 125

 att atc cta agc aaa cta atg cag aaa cag aaa gcc aaa tac tgc atg      432
 Ile Ile Leu Ser Lys Leu Met Gln Lys Gln Lys Ala Lys Tyr Cys Met
     130                 135                 140

 ttc tca ctt ata gag gtt gag aag tcc aag atc aag gca ctg aat ctg      480
 Phe Ser Leu Ile Glu Val Glu Lys Ser Lys Ile Lys Ala Leu Asn Leu
 145                 150                 155                 160

 agg atg cag caa caa ggc acc agc ttg gaa gca gag atc aaa ccc tta      528
 Arg Met Gln Gln Gln Gly Thr Ser Leu Glu Ala Glu Ile Lys Pro Leu
                 165                 170                 175

 tca gat gcc aaa cct gct tat gcc ttg atc tgg gac ttc cca gcc tcc      576
 Ser Asp Ala Lys Pro Ala Tyr Ala Leu Ile Trp Asp Phe Pro Ala Ser
             180                 185                 190

 aga acc atg aga aat aaa ttt cta ttg ttt gtg aat tac ccg gtc tat      624
 Arg Thr Met Arg Asn Lys Phe Leu Leu Phe Val Asn Tyr Pro Val Tyr
         195                 200                 205

 ggt ctg cag gaa aag ggg gaa gag tct tta cag gtg gca ctg tgt gga      672
 Gly Leu Gln Glu Lys Gly Glu Glu Ser Leu Gln Val Ala Leu Cys Gly
     210                 215                 220

 gag agc cac cca aca gga atg gtg gcc ttc atc aag gaa tgc agc cag      720
 Glu Ser His Pro Thr Gly Met Val Ala Phe Ile Lys Glu Cys Ser Gln
 225                 230                 235                 240

 ccc ggg gaa ccc tca cct caa gga agc aag gcg aat cga tac ttc acc      768
 Pro Gly Glu Pro Ser Pro Gln Gly Ser Lys Ala Asn Arg Tyr Phe Thr
                 245                 250                 255

 ctt tcc ttc ctc ctt ccc tct cac gtc ctg cca gta ttc tcc att ggc      816
 Leu Ser Phe Leu Leu Pro Ser His Val Leu Pro Val Phe Ser Ile Gly
             260                 265                 270

 caa gcc cag ccc aga atc cag aaa acc agg gaa tct gct gac act gcc      864
 Gln Ala Gln Pro Arg Ile Gln Lys Thr Arg Glu Ser Ala Asp Thr Ala
         275                 280                 285

 cat cca gtg tgt cct caa aca aaa gat ggc cat gtc aga ata cca caa      912
 His Pro Val Cys Pro Gln Thr Lys Asp Gly His Val Arg Ile Pro Gln
     290                 295                 300

 agg ctt gtg gac tgt gcc gct gct gat gtt gga aga aga cgt ttc ttt      960
 Arg Leu Val Asp Cys Ala Ala Ala Asp Val Gly Arg Arg Arg Phe Phe
 305                 310                 315                 320

 ggc aag caa gga gga ttt gag cag acg aac gac tta ggt aag aga aaa     1008
 Gly Lys Gln Gly Gly Phe Glu Gln Thr Asn Asp Leu Gly Lys Arg Lys
                 325                 330                 335

 gac aaa taa                                                         1017
 Asp Lys 






      <210> 596
      <211> 777
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (1)..(777)

      <400> 596
  atg ctc att ggg aca ttt tgg att ttg gat ttt cac att tgg gat act      48
  Met Leu Ile Gly Thr Phe Trp Ile Leu Asp Phe His Ile Trp Asp Thr
    1               5                  10                  15

 caa ctg aga ttg aaa cca aca aat cca gca gcc cag aag gct ctt act       96
 Gln Leu Arg Leu Lys Pro Thr Asn Pro Ala Ala Gln Lys Ala Leu Thr
              20                  25                  30

 aca cct act cat tat aaa ctg aca ccc cgc cct gcc act aga gtc cgg      144
 Thr Pro Thr His Tyr Lys Leu Thr Pro Arg Pro Ala Thr Arg Val Arg
          35                  40                  45

 cca aag gct tta caa aca aca ggc aca gcc aag tca cat ctc ttt gat      192
 Pro Lys Ala Leu Gln Thr Thr Gly Thr Ala Lys Ser His Leu Phe Asp
      50                  55                  60

 ggg ctg gat gac gat gaa cca tcc cta gcc aat gga gca ttc atg ccc      240
 Gly Leu Asp Asp Asp Glu Pro Ser Leu Ala Asn Gly Ala Phe Met Pro
  65                  70                  75                  80

 aag aag agc att aag aag ttg gtt ttg aag aac ctt aat aat agc aat      288
 Lys Lys Ser Ile Lys Lys Leu Val Leu Lys Asn Leu Asn Asn Ser Asn
                  85                  90                  95

 ctc ttt tct cct gtt aat cgt gat tca gaa aat cta gct tca cca tct      336
 Leu Phe Ser Pro Val Asn Arg Asp Ser Glu Asn Leu Ala Ser Pro Ser
             100                 105                 110

 gaa tat cca gaa aat gga gag aga ttt agt ttc cta agc aaa cct gtt      384
 Glu Tyr Pro Glu Asn Gly Glu Arg Phe Ser Phe Leu Ser Lys Pro Val
         115                 120                 125

 gat gag aat cac cag cag gat gga gat gaa gat tcc ctt gtt tca cat      432
 Asp Glu Asn His Gln Gln Asp Gly Asp Glu Asp Ser Leu Val Ser His
     130                 135                 140

 ttt tat act aac cct att gcc aaa cct att cct caa acc cca gaa agt      480
 Phe Tyr Thr Asn Pro Ile Ala Lys Pro Ile Pro Gln Thr Pro Glu Ser
 145                 150                 155                 160

 gct gga aat aaa cac agc aac agc aac agt gtg gat gat acc att gtt      528
 Ala Gly Asn Lys His Ser Asn Ser Asn Ser Val Asp Asp Thr Ile Val
                 165                 170                 175

 gca tta aac atg cgt gct gct ttg cga aat ggg ctg gaa gga agc agt      576
 Ala Leu Asn Met Arg Ala Ala Leu Arg Asn Gly Leu Glu Gly Ser Ser
             180                 185                 190

 gaa gaa acg tct ttt cat gat gag tca ctt cag gat gac cga gaa gaa      624
 Glu Glu Thr Ser Phe His Asp Glu Ser Leu Gln Asp Asp Arg Glu Glu
         195                 200                 205

 ata gaa aat aat tct tac cat atg cac cca gca ggt cag gtt cag att      672
 Ile Glu Asn Asn Ser Tyr His Met His Pro Ala Gly Gln Val Gln Ile
     210                 215                 220

 ggt gca tgt tta atc tct tac cag tca ttc gag atg act tgc ttg ttg      720
 Gly Ala Cys Leu Ile Ser Tyr Gln Ser Phe Glu Met Thr Cys Leu Leu
 225                 230                 235                 240

 cag ata ttc aac ata tgg aag tca gct gtt tgg cat ttt aag tat tat      768
 Gln Ile Phe Asn Ile Trp Lys Ser Ala Val Trp His Phe Lys Tyr Tyr
                 245                 250                 255

 ttt atg tga                                                          777
 Phe Met 






      <210> 597
      <211> 2124
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (1)..(2124)

      <400> 597
  atg gcc ccc gcc gct ccc gcc acg ttg gcc acg tgg atg gcc acc ttc      48
  Met Ala Pro Ala Ala Pro Ala Thr Leu Ala Thr Trp Met Ala Thr Phe
    1               5                  10                  15

 tca ggc tgt tgc aca ggt gcg ggg act tgt gat aac agg gtc ccc gac       96
 Ser Gly Cys Cys Thr Gly Ala Gly Thr Cys Asp Asn Arg Val Pro Asp
              20                  25                  30

 acg gtg ctg act tgt gat aac agg gtc ccc gac aca gtg ctg act tgt      144
 Thr Val Leu Thr Cys Asp Asn Arg Val Pro Asp Thr Val Leu Thr Cys
          35                  40                  45

 gat aac agg gtc ccc gac acg gtg ctg act tgt gat aac agg gtc ccc      192
 Asp Asn Arg Val Pro Asp Thr Val Leu Thr Cys Asp Asn Arg Val Pro
      50                  55                  60

 gac acg gtg ctg act tgt gat aac agg tgt gtg agc acg cac ata cac      240
 Asp Thr Val Leu Thr Cys Asp Asn Arg Cys Val Ser Thr His Ile His
  65                  70                  75                  80

 aca tac aca cac agc ggc cgg gag cac cgc agc aca ccg ttg agc ctt      288
 Thr Tyr Thr His Ser Gly Arg Glu His Arg Ser Thr Pro Leu Ser Leu
                  85                  90                  95

 cgg gcc ttc cct cct gct ggg tcc aca gag gag ggg aac ata cgg tcc      336
 Arg Ala Phe Pro Pro Ala Gly Ser Thr Glu Glu Gly Asn Ile Arg Ser
             100                 105                 110

 cta atg agc aca gag aag acc aag ggc ttc tgc cag ctg gtg gtc tcg      384
 Leu Met Ser Thr Glu Lys Thr Lys Gly Phe Cys Gln Leu Val Val Ser
         115                 120                 125

 tcc agc ctg cgg gat ggc atg tcc cac ctg atc cag tcg gcc ggc ctg      432
 Ser Ser Leu Arg Asp Gly Met Ser His Leu Ile Gln Ser Ala Gly Leu
     130                 135                 140

 ggc ggc ctg aag cac aac acg gtg ctc atg gcc tgg ccc gca tcc tgg      480
 Gly Gly Leu Lys His Asn Thr Val Leu Met Ala Trp Pro Ala Ser Trp
 145                 150                 155                 160

 aag cag gag gac aac ccc ttc tcc tgg aag aac ttt gta gac acc gtc      528
 Lys Gln Glu Asp Asn Pro Phe Ser Trp Lys Asn Phe Val Asp Thr Val
                 165                 170                 175

 cgc gac acc acc gcc gcg cac cag gct ctg ctg gtg gcc aag aac gtc      576
 Arg Asp Thr Thr Ala Ala His Gln Ala Leu Leu Val Ala Lys Asn Val
             180                 185                 190

 gac tcg ttt ccg caa aac cag gag cgc ttc ggc ggg ggc cac atc gac      624
 Asp Ser Phe Pro Gln Asn Gln Glu Arg Phe Gly Gly Gly His Ile Asp
         195                 200                 205

 gtg tgg tgg atc gtg cac gac ggc ggc atg ctc atg ctg ctg ccc ttc      672
 Val Trp Trp Ile Val His Asp Gly Gly Met Leu Met Leu Leu Pro Phe
     210                 215                 220

 ctg ctg cgc cag cac aag gtg tgg agg aag tgc cgg atg cgt atc ttc      720
 Leu Leu Arg Gln His Lys Val Trp Arg Lys Cys Arg Met Arg Ile Phe
 225                 230                 235                 240

 acc gtg gcc cag gtg gac gac aac agc atc cag atg aag aag gac ctg      768
 Thr Val Ala Gln Val Asp Asp Asn Ser Ile Gln Met Lys Lys Asp Leu
                 245                 250                 255

 cag atg ttc ttg tac cac ttg cgc atc agc gcc gag gtg gag gtg gtg      816
 Gln Met Phe Leu Tyr His Leu Arg Ile Ser Ala Glu Val Glu Val Val
             260                 265                 270

 gag atg gtt gaa aac gac ata tct gct ttc acc tac gag agg aca cta      864
 Glu Met Val Glu Asn Asp Ile Ser Ala Phe Thr Tyr Glu Arg Thr Leu
         275                 280                 285

 atg atg gag cag agg tcg cag atg ctg aag cag atg cag ctg tcc aag      912
 Met Met Glu Gln Arg Ser Gln Met Leu Lys Gln Met Gln Leu Ser Lys
     290                 295                 300

 aac gag cag gag cga gag ccc acg acg gtc ctc cag aga gca tgc ctc      960
 Asn Glu Gln Glu Arg Glu Pro Thr Thr Val Leu Gln Arg Ala Cys Leu
 305                 310                 315                 320

 agg aac ctg cag tac acg ggt ctg cgt gtg ggg cca tat gtg ctg aca     1008
 Arg Asn Leu Gln Tyr Thr Gly Leu Arg Val Gly Pro Tyr Val Leu Thr
                 325                 330                 335

 gcc gga atc act aag cag cga ctg ctg ctc tcc ccc aac aga gaa agg     1056
 Ala Gly Ile Thr Lys Gln Arg Leu Leu Leu Ser Pro Asn Arg Glu Arg
             340                 345                 350

 cgt gtg gag ctg cgg tcc tgt cca ctc cca gac ccc ggg cag gcc agg     1104
 Arg Val Glu Leu Arg Ser Cys Pro Leu Pro Asp Pro Gly Gln Ala Arg
         355                 360                 365

 tcc ctg aga tcc ggc agg gtc gcc ctg gcg tca caa ggg ttc agc ccg     1152
 Ser Leu Arg Ser Gly Arg Val Ala Leu Ala Ser Gln Gly Phe Ser Pro
     370                 375                 380

 ggt cca gct agg aac aag aat cca ccc atg gct tca tgg gaa gtt cag     1200
 Gly Pro Ala Arg Asn Lys Asn Pro Pro Met Ala Ser Trp Glu Val Gln
 385                 390                 395                 400

 tgt gga gag tca gca aat gct gac cga gga ggg acc ggg agc ggg aac     1248
 Cys Gly Glu Ser Ala Asn Ala Asp Arg Gly Gly Thr Gly Ser Gly Asn
                 405                 410                 415

 agc aag ctc gag ctc gaa ggg ccc ctc ctg ggc cag gcc cag ctg atc     1296
 Ser Lys Leu Glu Leu Glu Gly Pro Leu Leu Gly Gln Ala Gln Leu Ile
             420                 425                 430

 cac gac agg aac acc gcg tcc cac acc gcg gcg gca gcc agg acc caa     1344
 His Asp Arg Asn Thr Ala Ser His Thr Ala Ala Ala Ala Arg Thr Gln
         435                 440                 445

 gcg ccg cct acg cca gac aag gtg cag atg acc tgg acc agg gag aag     1392
 Ala Pro Pro Thr Pro Asp Lys Val Gln Met Thr Trp Thr Arg Glu Lys
     450                 455                 460

 ctg atc gct gag aag tac agg agc aga gac acc agc cta tct ggt ttc     1440
 Leu Ile Ala Glu Lys Tyr Arg Ser Arg Asp Thr Ser Leu Ser Gly Phe
 465                 470                 475                 480

 aaa gac ctc ttc agc atg aag ccg cct ggg agc ttc agc agc aac ggc     1488
 Lys Asp Leu Phe Ser Met Lys Pro Pro Gly Ser Phe Ser Ser Asn Gly
                 485                 490                 495

 tgc aca ggc cgg gac cag tcc aac gtc agg cgg atg cac acg gct gtg     1536
 Cys Thr Gly Arg Asp Gln Ser Asn Val Arg Arg Met His Thr Ala Val
             500                 505                 510

 aag ctc aat ggc gtc gtc ctc aac aag tcc cag gat gcg cag ctg gtc     1584
 Lys Leu Asn Gly Val Val Leu Asn Lys Ser Gln Asp Ala Gln Leu Val
         515                 520                 525

 ctg ctc aac atg cca ggt cct ccc aaa aac cgg cag gga gac gag aac     1632
 Leu Leu Asn Met Pro Gly Pro Pro Lys Asn Arg Gln Gly Asp Glu Asn
     530                 535                 540

 tgt atc ctt tct tgc agt gtg cct gct gag cgt gcg ggc acc ccc tgg     1680
 Cys Ile Leu Ser Cys Ser Val Pro Ala Glu Arg Ala Gly Thr Pro Trp
 545                 550                 555                 560

 tgg ctt ctc gct aag acc tgg gct cag caa atc agg gcg tgg ctg gac     1728
 Trp Leu Leu Ala Lys Thr Trp Ala Gln Gln Ile Arg Ala Trp Leu Asp
                 565                 570                 575

 gat ttc ctt gca tct gag ggc aga cgc tgc tac cgg agt gac ctg gac     1776
 Asp Phe Leu Ala Ser Glu Gly Arg Arg Cys Tyr Arg Ser Asp Leu Asp
             580                 585                 590

 gtg gcc aga tct tct cgc agg tca caa gaa gcc agt gag ccc ttg cct     1824
 Val Ala Arg Ser Ser Arg Arg Ser Gln Glu Ala Ser Glu Pro Leu Pro
         595                 600                 605

 tgg ttt ctg gaa gtt ctt ttc ctt ggc tgg att tac cca gtg gtt agg     1872
 Trp Phe Leu Glu Val Leu Phe Leu Gly Trp Ile Tyr Pro Val Val Arg
     610                 615                 620

 ttg cat ttc tac ccc atc cag aac att ctt gga aga gca ccc gga gct     1920
 Leu His Phe Tyr Pro Ile Gln Asn Ile Leu Gly Arg Ala Pro Gly Ala
 625                 630                 635                 640

 gaa gct gtc cct gat gat gaa ggt gaa acg tca gcc ctg gcc atg gct     1968
 Glu Ala Val Pro Asp Asp Glu Gly Glu Thr Ser Ala Leu Ala Met Ala
                 645                 650                 655

 ccg ctc agg gcc ccg gtc acc tcc gag tca ctc tgt tcc ttg act gtc     2016
 Pro Leu Arg Ala Pro Val Thr Ser Glu Ser Leu Cys Ser Leu Thr Val
             660                 665                 670

 ttt gtg ttt ctg tac ctc aag gca ctg aag ctg gag gac tct gtc cat     2064
 Phe Val Phe Leu Tyr Leu Lys Ala Leu Lys Leu Glu Asp Ser Val His
         675                 680                 685

 gcc cgt gtc acc ctc gtg tgg gag cct ctg ggc tcg gca ggt cca cat     2112
 Ala Arg Val Thr Leu Val Trp Glu Pro Leu Gly Ser Ala Gly Pro His
     690                 695                 700

 ttc atg agc tga                                                     2124
 Phe Met Ser 
 705





      <210> 598
      <211> 699
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (566)..(699)

      <400> 598
 atggctctgt ccactttcct tactgagtcc gtggaagcag gaagtctacc tgagtctact     60

 ccacatgagg gaccagagac aaggcaagag acacacggcc cctgccatca agaagctcac    120

 attggctaca ctggtgaaga agctgagccc cagggagccc ccacagggag cactgacaga    180

 ggcagtccct gcagactctg tgagattgag gatccactct taattgcact ctcctcactg    240

 tcacttggaa tctccagtag agacatgaaa gcggggtcaa ctttcactga tccagcattt    300

 gtaccatctc ctccaatgag tgggactgta ttgggtgcag ggccctcatt tgcaggcaaa    360

 gtagtataca ccatgggcag agactgcacc acgactggga tggcattcag gcttttactg    420

 gttgaactgc ttttactcct ggttgaacac aaagttaagg cagagaagga aaccttcaag    480

 acagaaaccc atgaggagct accacaagat cccttcacct ccgccattgc tgccacacac    540

 cccagtgcct tccagaaagg aatca  tga atc agg cat ccc cca aac cag aac     592
                              Met Ile Pro Phe Trp Lys Ala Leu Gly
                                1               5

 agg ttc aga gag gcc cca gtg tag cca tgt ggc aga aga aga ttt atg      640
 Cys Val Ala Ala Met Ala Glu Val Lys Gly Ser Cys Gly Ser Ser Ser
  10                  15                  20                  25

 gag aga aaa agg aaa gtg gtg ctc aga aaa tgg aag tga ggt tca gaa      688
 Trp Val Ser Val Leu Lys Val Ser Phe Ser Ala Leu Thr Leu Cys Ser
                  30                  35                  40

 aac gga agt ga                                                       699
 Thr Arg Ser Lys Ser Ser Ser Thr Ser Lys Ser Leu Asn Ala Ile Pro 
              45                  50                  55





      <210> 599
      <211> 1335
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (1)..(1335)

      <220>
      <221> misc_feature
      <222> (1)...(1335)
      <223> n = a,t,c or g

      <400> 599
  atg agg nac aag ttg ctg tgc tcg gtt atc aca gcc atg ctg aag ttt      48
  Met Arg XXX Lys Leu Leu Cys Ser Val Ile Thr Ala Met Leu Lys Phe
    1               5                  10                  15

 tgg tgg ccc ctc ctc aat ccc agt aac cca aat tcc atc acg aaa ggg       96
 Trp Trp Pro Leu Leu Asn Pro Ser Asn Pro Asn Ser Ile Thr Lys Gly
              20                  25                  30

 aga ata caa agt gct cat ttc act tcc cat ctg ggg cat gtt gaa aca      144
 Arg Ile Gln Ser Ala His Phe Thr Ser His Leu Gly His Val Glu Thr
          35                  40                  45

 gtc caa aca tct gaa agg agg act aga gag aaa gaa ggc tca cct cgg      192
 Val Gln Thr Ser Glu Arg Arg Thr Arg Glu Lys Glu Gly Ser Pro Arg
      50                  55                  60

 aaa aaa cca cac aaa aac aaa aag cgg ccg cca aca aaa aca ggg agc      240
 Lys Lys Pro His Lys Asn Lys Lys Arg Pro Pro Thr Lys Thr Gly Ser
  65                  70                  75                  80

 cca aac caa acg tca cgt gac gcg gaa ggg gga aca ggg cat aaa ccc      288
 Pro Asn Gln Thr Ser Arg Asp Ala Glu Gly Gly Thr Gly His Lys Pro
                  85                  90                  95

 acc gct cca caa aaa gcc caa aaa aag gca gaa aac act cag cta aag      336
 Thr Ala Pro Gln Lys Ala Gln Lys Lys Ala Glu Asn Thr Gln Leu Lys
             100                 105                 110

 cta agg cca cgg cac aaa cac acc agc gat agc tca aac cac agc aag      384
 Leu Arg Pro Arg His Lys His Thr Ser Asp Ser Ser Asn His Ser Lys
         115                 120                 125

 agc caa cgc aga aac ccc ctt tta ttt act ctt gaa ata caa act acc      432
 Ser Gln Arg Arg Asn Pro Leu Leu Phe Thr Leu Glu Ile Gln Thr Thr
     130                 135                 140

 atc aga gaa tac tac aaa cac ctc tat gca aat aaa cta gaa aat cta      480
 Ile Arg Glu Tyr Tyr Lys His Leu Tyr Ala Asn Lys Leu Glu Asn Leu
 145                 150                 155                 160

 gaa gaa atg gat aaa ttc ctc gac aca tac acc ctc cca aga cta aac      528
 Glu Glu Met Asp Lys Phe Leu Asp Thr Tyr Thr Leu Pro Arg Leu Asn
                 165                 170                 175

 cag gaa gaa gtt gaa tct ctg aat aga cca ata aca ggc tct gaa act      576
 Gln Glu Glu Val Glu Ser Leu Asn Arg Pro Ile Thr Gly Ser Glu Thr
             180                 185                 190

 gtg gca ata atc aat agc tta cca acc aaa aag agt cca gga cca gat      624
 Val Ala Ile Ile Asn Ser Leu Pro Thr Lys Lys Ser Pro Gly Pro Asp
         195                 200                 205

 gga ttc aca gct gaa ttc tac cag agg tac aag gag gaa ctg aga ata      672
 Gly Phe Thr Ala Glu Phe Tyr Gln Arg Tyr Lys Glu Glu Leu Arg Ile
     210                 215                 220

 aag tac cta gaa atc caa ctt aca agg gat gtg aag gac ctc ttc aag      720
 Lys Tyr Leu Glu Ile Gln Leu Thr Arg Asp Val Lys Asp Leu Phe Lys
 225                 230                 235                 240

 gag aac tac aaa cca ctg ctc aag gaa ata aaa gag gac aca aac aaa      768
 Glu Asn Tyr Lys Pro Leu Leu Lys Glu Ile Lys Glu Asp Thr Asn Lys
                 245                 250                 255

 tgg aag aac att cca tgc tca tgg gta aga aga atc aat atc gtg aaa      816
 Trp Lys Asn Ile Pro Cys Ser Trp Val Arg Arg Ile Asn Ile Val Lys
             260                 265                 270

 atg gcc ata ctg ccc aag aga ata aaa tac cta gga atc caa ctt aca      864
 Met Ala Ile Leu Pro Lys Arg Ile Lys Tyr Leu Gly Ile Gln Leu Thr
         275                 280                 285

 agg gat gtg aag gac ctc ttc aag gag aac tac aaa cca ctg ctc aac      912
 Arg Asp Val Lys Asp Leu Phe Lys Glu Asn Tyr Lys Pro Leu Leu Asn
     290                 295                 300

 gaa ata aaa gag gac aca aac aaa tgg aag aac att cca tgc tca tgg      960
 Glu Ile Lys Glu Asp Thr Asn Lys Trp Lys Asn Ile Pro Cys Ser Trp
 305                 310                 315                 320

 ata gga aga atc aat atc atg aaa atg gcc ata ctg ccc aag cac aag     1008
 Ile Gly Arg Ile Asn Ile Met Lys Met Ala Ile Leu Pro Lys His Lys
                 325                 330                 335

 cag gac gat atg gaa gta aag aca gag aac cgt aga ggg caa cag aaa     1056
 Gln Asp Asp Met Glu Val Lys Thr Glu Asn Arg Arg Gly Gln Gln Lys
             340                 345                 350

 aaa atg gcc aaa ccc atc ccc gaa aaa gga gat ata agg agg aga cgc     1104
 Lys Met Ala Lys Pro Ile Pro Glu Lys Gly Asp Ile Arg Arg Arg Arg
         355                 360                 365

 ctc tat cct cca atc gga gag ctg agc acc tcc gga ggt gag ggt ttc     1152
 Leu Tyr Pro Pro Ile Gly Glu Leu Ser Thr Ser Gly Gly Glu Gly Phe
     370                 375                 380

 ttt ttc tcc agc agg tgg ttt tcg cag aga tct gtt ata tct gaa gtt     1200
 Phe Phe Ser Ser Arg Trp Phe Ser Gln Arg Ser Val Ile Ser Glu Val
 385                 390                 395                 400

 ccg cca gag aag gcc act gtc atc act cac ctt gac gac tgc aga cga     1248
 Pro Pro Glu Lys Ala Thr Val Ile Thr His Leu Asp Asp Cys Arg Arg
                 405                 410                 415

 ctc cta acg att cga ctg tca gtc ttt ccc act tct aat cta gca atg     1296
 Leu Leu Thr Ile Arg Leu Ser Val Phe Pro Thr Ser Asn Leu Ala Met
             420                 425                 430

 gct cat tca aca aat acc tgc tgt gtg cct act atg taa                 1335
 Ala His Ser Thr Asn Thr Cys Cys Val Pro Thr Met 
         435                 440





      <210> 600
      <211> 1353
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (1)..(1353)

      <400> 600
  atg aac tgt gca ctg cac cca ctg tcc tgc atc tgc tgt ctg gca ctc      48
  Met Asn Cys Ala Leu His Pro Leu Ser Cys Ile Cys Cys Leu Ala Leu
    1               5                  10                  15

 cct att gag atg aac ctg gta cct cag atg gaa atg cag aaa tca ccc       96
 Pro Ile Glu Met Asn Leu Val Pro Gln Met Glu Met Gln Lys Ser Pro
              20                  25                  30

 gtc ttc tgc att gct gac act ggg agc tgt aga ccg gag ctg ttc cta      144
 Val Phe Cys Ile Ala Asp Thr Gly Ser Cys Arg Pro Glu Leu Phe Leu
          35                  40                  45

 ttc ggc cat ctt ggc tac act tgg att gca gaa cac tgc tac gat tat      192
 Phe Gly His Leu Gly Tyr Thr Trp Ile Ala Glu His Cys Tyr Asp Tyr
      50                  55                  60

 ctg aat gtt gtc cct cac aaa gta tta cag agc act gct gct ggg ttc      240
 Leu Asn Val Val Pro His Lys Val Leu Gln Ser Thr Ala Ala Gly Phe
  65                  70                  75                  80

 tct ctg ttt gcc cct cac att gga tta cag aac act gct gct agg ttt      288
 Ser Leu Phe Ala Pro His Ile Gly Leu Gln Asn Thr Ala Ala Arg Phe
                  85                  90                  95

 gag gga ttc cag aac act gct gct ggg ttc tta gtg ttt gac cct cac      336
 Glu Gly Phe Gln Asn Thr Ala Ala Gly Phe Leu Val Phe Asp Pro His
             100                 105                 110

 ata gga ttc cag aac act gct gct ggg ttc cga gtg ttt ctc cct cac      384
 Ile Gly Phe Gln Asn Thr Ala Ala Gly Phe Arg Val Phe Leu Pro His
         115                 120                 125

 ata gga ttc cag aac act gct gct cgg ttc tgt gtt tgt ccc tca cat      432
 Ile Gly Phe Gln Asn Thr Ala Ala Arg Phe Cys Val Cys Pro Ser His
     130                 135                 140

 agc att cca gaa cac aga aaa cgg cta cga cgg tct gaa ttt ttg tcc      480
 Ser Ile Pro Glu His Arg Lys Arg Leu Arg Arg Ser Glu Phe Leu Ser
 145                 150                 155                 160

 atc aca aag gat ttt aga aca ctg ctg ctg gat ctg agt gtt tgt ccc      528
 Ile Thr Lys Asp Phe Arg Thr Leu Leu Leu Asp Leu Ser Val Cys Pro
                 165                 170                 175

 tca cac agg att cca gaa cac tgc ttc gat ggt ctg aat gat tcc gga      576
 Ser His Arg Ile Pro Glu His Cys Phe Asp Gly Leu Asn Asp Ser Gly
             180                 185                 190

 aca ctg cta cga ggg tct gaa tgt tta tcc ctt aca aag gat tac aga      624
 Thr Leu Leu Arg Gly Ser Glu Cys Leu Ser Leu Thr Lys Asp Tyr Arg
         195                 200                 205

 aca gtt ctg gaa tcc tat gtg agg gac aaa cac tca gaa ccc agc agt      672
 Thr Val Leu Glu Ser Tyr Val Arg Asp Lys His Ser Glu Pro Ser Ser
     210                 215                 220

 gtt ctg gaa tcc tat gtg agg gat gta gcc ata gaa ttc tgt ctg gag      720
 Val Leu Glu Ser Tyr Val Arg Asp Val Ala Ile Glu Phe Cys Leu Glu
 225                 230                 235                 240

 gag tgt caa tac ctg gat gct gct cag cag aat ttg tgt atg gat gtg      768
 Glu Cys Gln Tyr Leu Asp Ala Ala Gln Gln Asn Leu Cys Met Asp Val
                 245                 250                 255

 atg tta cag aac tac aga aac cct gtc ttc ttg gtt gag gat aac ttc      816
 Met Leu Gln Asn Tyr Arg Asn Pro Val Phe Leu Val Glu Asp Asn Phe
             260                 265                 270

 aat ata gaa ttc cta att tac cct aaa ggt ttc att ttc ttc ctt tgt      864
 Asn Ile Glu Phe Leu Ile Tyr Pro Lys Gly Phe Ile Phe Phe Leu Cys
         275                 280                 285

 agg atg tgt ttt gcc aga cct ggt cac ctg tct gga gca aag gaa aaa      912
 Arg Met Cys Phe Ala Arg Pro Gly His Leu Ser Gly Ala Lys Glu Lys
     290                 295                 300

 gcc atg gag tat gaa gca ccc agg agt gag cca cca tgc cca gcc ttc      960
 Ala Met Glu Tyr Glu Ala Pro Arg Ser Glu Pro Pro Cys Pro Ala Phe
 305                 310                 315                 320

 ttg gct gat ttt caa cag ttg tct tat tat gtg aag aga att cat agt     1008
 Leu Ala Asp Phe Gln Gln Leu Ser Tyr Tyr Val Lys Arg Ile His Ser
                 325                 330                 335

 gga gag aaa ccc tac aaa tgt gaa gaa tgt ggc aaa gcc ttt aag caa     1056
 Gly Glu Lys Pro Tyr Lys Cys Glu Glu Cys Gly Lys Ala Phe Lys Gln
             340                 345                 350

 tct tca aaa ctg aat gaa cat atg aaa gct cat act gga gag aaa ttc     1104
 Ser Ser Lys Leu Asn Glu His Met Lys Ala His Thr Gly Glu Lys Phe
         355                 360                 365

 tac aaa tgt gaa gaa tgt ggc aaa gct ttt aag caa cct tca ggc ctt     1152
 Tyr Lys Cys Glu Glu Cys Gly Lys Ala Phe Lys Gln Pro Ser Gly Leu
     370                 375                 380

 act cta cat aag aga att cat act gga gag aac cct tac aaa ttc gaa     1200
 Thr Leu His Lys Arg Ile His Thr Gly Glu Asn Pro Tyr Lys Phe Glu
 385                 390                 395                 400

 gaa tgt ggg aca tgg atg aaa ttg gaa atc atc att ctc agt aaa cta     1248
 Glu Cys Gly Thr Trp Met Lys Leu Glu Ile Ile Ile Leu Ser Lys Leu
                 405                 410                 415

 tcg caa gaa caa aaa acc aaa cac cgc ata ttc tca ctc ata gga tgt     1296
 Ser Gln Glu Gln Lys Thr Lys His Arg Ile Phe Ser Leu Ile Gly Cys
             420                 425                 430

 cac agt acc caa acg gaa gga ctg gct gaa gcc atg gca gaa gaa tgt     1344
 His Ser Thr Gln Thr Glu Gly Leu Ala Glu Ala Met Ala Glu Glu Cys
         435                 440                 445

 gga ttg tga                                                         1353
 Gly Leu 
     450





      <210> 601
      <211> 2823
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (1)..(2823)

      <400> 601
  atg atc cgg cat tgt cct gcg ttc agt cat aga tgt gtc aag cac gct      48
  Met Ile Arg His Cys Pro Ala Phe Ser His Arg Cys Val Lys His Ala
    1               5                  10                  15

 cag agc gtc cag acc ctt ctt gcc ttt gtt gtt ttt ata aaa ggt ttc       96
 Gln Ser Val Gln Thr Leu Leu Ala Phe Val Val Phe Ile Lys Gly Phe
              20                  25                  30

 att gaa ttg ctt att aaa act gct gta tat aaa act act cct ttg aaa      144
 Ile Glu Leu Leu Ile Lys Thr Ala Val Tyr Lys Thr Thr Pro Leu Lys
          35                  40                  45

 gat ttc cct ggc ttg cct cca gct caa tta gca gac tac ttc cag ccg      192
 Asp Phe Pro Gly Leu Pro Pro Ala Gln Leu Ala Asp Tyr Phe Gln Pro
      50                  55                  60

 atg aaa aca tcc ttt ggc gag tgc ctt tct gcc cag cat gtt gta gag      240
 Met Lys Thr Ser Phe Gly Glu Cys Leu Ser Ala Gln His Val Val Glu
  65                  70                  75                  80

 gat tca gca aga ctg tgt ctc ctg act tcc tct att gtt cat gcc caa      288
 Asp Ser Ala Arg Leu Cys Leu Leu Thr Ser Ser Ile Val His Ala Gln
                  85                  90                  95

 ctc cag gac cgg caa gca ccg ggg aac cgt ccg cca tac ttc tcg gaa      336
 Leu Gln Asp Arg Gln Ala Pro Gly Asn Arg Pro Pro Tyr Phe Ser Glu
             100                 105                 110

 act ggg atc tgg cta act gga gga tgg aag gct gtc tta gac tcc ttt      384
 Thr Gly Ile Trp Leu Thr Gly Gly Trp Lys Ala Val Leu Asp Ser Phe
         115                 120                 125

 acc tca cgg gac ccc gtc ctg cca tct cac tgc aag tct cct tcc ccc      432
 Thr Ser Arg Asp Pro Val Leu Pro Ser His Cys Lys Ser Pro Ser Pro
     130                 135                 140

 tgc tct ggt agc aca aag agg ggc cat ggc tat gca ttt ggg tgg aaa      480
 Cys Ser Gly Ser Thr Lys Arg Gly His Gly Tyr Ala Phe Gly Trp Lys
 145                 150                 155                 160

 aat gag caa gca gtt ttc aca acc tgc aga gtg aaa act gga acc cag      528
 Asn Glu Gln Ala Val Phe Thr Thr Cys Arg Val Lys Thr Gly Thr Gln
                 165                 170                 175

 aaa ggg atg gac aaa tgc gag tgt gtt tgg caa gga gca gaa cta atc      576
 Lys Gly Met Asp Lys Cys Glu Cys Val Trp Gln Gly Ala Glu Leu Ile
             180                 185                 190

 tgc aaa ctg ctg ctg ctt cct gga tca cag aaa gta gaa aag gct ccc      624
 Cys Lys Leu Leu Leu Leu Pro Gly Ser Gln Lys Val Glu Lys Ala Pro
         195                 200                 205

 tac agc aac cct gat gac tcc aaa ttt att att tct tct tca att gct      672
 Tyr Ser Asn Pro Asp Asp Ser Lys Phe Ile Ile Ser Ser Ser Ile Ala
     210                 215                 220

 cca cga cat gcc ctc ata ttt agg agt tat gga gac ttt ata ctg cga      720
 Pro Arg His Ala Leu Ile Phe Arg Ser Tyr Gly Asp Phe Ile Leu Arg
 225                 230                 235                 240

 agc tca aag gga atc tgg aga gaa gga cac agc agc agc acc aaa aag      768
 Ser Ser Lys Gly Ile Trp Arg Glu Gly His Ser Ser Ser Thr Lys Lys
                 245                 250                 255

 ctg atg aat cct gta ttc aca tct cca acc cag agc ttg tgg gag tgc      816
 Leu Met Asn Pro Val Phe Thr Ser Pro Thr Gln Ser Leu Trp Glu Cys
             260                 265                 270

 cag ggc cgt att tgc att ttt tgc tgg aca aat cct cct gac tac ctc      864
 Gln Gly Arg Ile Cys Ile Phe Cys Trp Thr Asn Pro Pro Asp Tyr Leu
         275                 280                 285

 aca ggt act tcc aac tca ctg gat ccc atc ctt cag gaa caa act gct      912
 Thr Gly Thr Ser Asn Ser Leu Asp Pro Ile Leu Gln Glu Gln Thr Ala
     290                 295                 300

 tct ttc tct ctg gcc act gca ttc cag gtc tca atc cag cgc cca gaa      960
 Ser Phe Ser Leu Ala Thr Ala Phe Gln Val Ser Ile Gln Arg Pro Glu
 305                 310                 315                 320

 cat cac ggg cat tca gta aaa att agt cgt gct gaa aac att atg ctc     1008
 His His Gly His Ser Val Lys Ile Ser Arg Ala Glu Asn Ile Met Leu
                 325                 330                 335

 gct gaa aaa agc cag aca aca aaa gac atg gaa cct gaa gcc cag aga     1056
 Ala Glu Lys Ser Gln Thr Thr Lys Asp Met Glu Pro Glu Ala Gln Arg
             340                 345                 350

 gat tca ttg caa gca gag gtg tta ctg cag caa gct gga gcc ttg gaa     1104
 Asp Ser Leu Gln Ala Glu Val Leu Leu Gln Gln Ala Gly Ala Leu Glu
         355                 360                 365

 gac agc agc cat cag gac cag aat atc agc gtg aga ata gac caa aac     1152
 Asp Ser Ser His Gln Asp Gln Asn Ile Ser Val Arg Ile Asp Gln Asn
     370                 375                 380

 aga gga tta aga tca aga aga cat gat gtt gac ttc agg gac acc agg     1200
 Arg Gly Leu Arg Ser Arg Arg His Asp Val Asp Phe Arg Asp Thr Arg
 385                 390                 395                 400

 aac agt gca gaa ccc tgt tac ccc aga gca ggc act aat cta agt agt     1248
 Asn Ser Ala Glu Pro Cys Tyr Pro Arg Ala Gly Thr Asn Leu Ser Ser
                 405                 410                 415

 gat gaa aag tca agg aca ctt tct gga gca gga gag gga tgg gat gag     1296
 Asp Glu Lys Ser Arg Thr Leu Ser Gly Ala Gly Glu Gly Trp Asp Glu
             420                 425                 430

 agc ttt atg aag atg aat cta aca gca acg ggt gaa ggg gcg agc ggg     1344
 Ser Phe Met Lys Met Asn Leu Thr Ala Thr Gly Glu Gly Ala Ser Gly
         435                 440                 445

 gaa tct ggc agt gac cct gca aag gcc aca ctg gtt atg gag aag gga     1392
 Glu Ser Gly Ser Asp Pro Ala Lys Ala Thr Leu Val Met Glu Lys Gly
     450                 455                 460

 atg gaa aag agg aag gaa ggt gat gga tgt gtc tgg ggt ata ttc cat     1440
 Met Glu Lys Arg Lys Glu Gly Asp Gly Cys Val Trp Gly Ile Phe His
 465                 470                 475                 480

 gca aag cac tcc cag gca ggc act gga agt gtg ggc tgc agt gca gat     1488
 Ala Lys His Ser Gln Ala Gly Thr Gly Ser Val Gly Cys Ser Ala Asp
                 485                 490                 495

 gag aga gaa gag tta ggg gtg gct cag gag tca atg agg aca gga gga     1536
 Glu Arg Glu Glu Leu Gly Val Ala Gln Glu Ser Met Arg Thr Gly Gly
             500                 505                 510

 aag atc aca agg agg gct ttc aag aac acc tgc att cgg gga ctg gga     1584
 Lys Ile Thr Arg Arg Ala Phe Lys Asn Thr Cys Ile Arg Gly Leu Gly
         515                 520                 525

 aca agt gaa gaa gcc caa gaa gaa caa aaa caa tca cat ccc aac cag     1632
 Thr Ser Glu Glu Ala Gln Glu Glu Gln Lys Gln Ser His Pro Asn Gln
     530                 535                 540

 tct aaa cct gtg ctg tcc aat atg gca gcc acc atg cat ttg cga cca     1680
 Ser Lys Pro Val Leu Ser Asn Met Ala Ala Thr Met His Leu Arg Pro
 545                 550                 555                 560

 gga caa atg gat gac att tac ata cgt gaa gag aag tct gca gcc ctg     1728
 Gly Gln Met Asp Asp Ile Tyr Ile Arg Glu Glu Lys Ser Ala Ala Leu
                 565                 570                 575

 gcg atg tct att cat ttc atc ata tcc gca gta ttt gtg aac tat aat     1776
 Ala Met Ser Ile His Phe Ile Ile Ser Ala Val Phe Val Asn Tyr Asn
             580                 585                 590

 aca cct tcc tgg aac acc aac act cgt ttc tcc caa gaa agc aca gaa     1824
 Thr Pro Ser Trp Asn Thr Asn Thr Arg Phe Ser Gln Glu Ser Thr Glu
         595                 600                 605

 cca gcc ata agg gga tta gtg agc gat aat tcg aac aac atg tta gaa     1872
 Pro Ala Ile Arg Gly Leu Val Ser Asp Asn Ser Asn Asn Met Leu Glu
     610                 615                 620

 ctg ggt cat gga gag ggc ctc aat gct gga caa aga aac ctg gac ttc     1920
 Leu Gly His Gly Glu Gly Leu Asn Ala Gly Gln Arg Asn Leu Asp Phe
 625                 630                 635                 640

 att ttt ggc tgg gga gaa ttg gtg cag act tca gat gga ggg act gac     1968
 Ile Phe Gly Trp Gly Glu Leu Val Gln Thr Ser Asp Gly Gly Thr Asp
                 645                 650                 655

 aag atg cac aat gac aca gag gca gga gcc cgg gac tgg gtg tca gga     2016
 Lys Met His Asn Asp Thr Glu Ala Gly Ala Arg Asp Trp Val Ser Gly
             660                 665                 670

 agc ccc tgg ttg gta gtg gtg ctc ccc acc cgc agg ggc tgg gcc aga     2064
 Ser Pro Trp Leu Val Val Val Leu Pro Thr Arg Arg Gly Trp Ala Arg
         675                 680                 685

 caa tct cta aaa ttc cca cac act cga aga aaa agt ctg agt cca gga     2112
 Gln Ser Leu Lys Phe Pro His Thr Arg Arg Lys Ser Leu Ser Pro Gly
     690                 695                 700

 aga gag ctg tat ttt cag gag atg tat ctg gca ctc atg gag cca gag     2160
 Arg Glu Leu Tyr Phe Gln Glu Met Tyr Leu Ala Leu Met Glu Pro Glu
 705                 710                 715                 720

 gcc aga agc cta agg act acg gag gag gct aca ggc aca gta caa gag     2208
 Ala Arg Ser Leu Arg Thr Thr Glu Glu Ala Thr Gly Thr Val Gln Glu
                 725                 730                 735

 aca tgt caa cat gag gac cag agt atg gta tct gaa gca gaa agt ggg     2256
 Thr Cys Gln His Glu Asp Gln Ser Met Val Ser Glu Ala Glu Ser Gly
             740                 745                 750

 agc aac ata gaa atg ccc gca gca ttg aaa aag gaa aaa tat atc gga     2304
 Ser Asn Ile Glu Met Pro Ala Ala Leu Lys Lys Glu Lys Tyr Ile Gly
         755                 760                 765

 ctt atg cat tta gtg aag aac agt aga agc tgt aag tct cga aca ctt     2352
 Leu Met His Leu Val Lys Asn Ser Arg Ser Cys Lys Ser Arg Thr Leu
     770                 775                 780

 ctc aaa ggg aca cag aaa aat ggc gta agg aat ata aga atg gga tta     2400
 Leu Lys Gly Thr Gln Lys Asn Gly Val Arg Asn Ile Arg Met Gly Leu
 785                 790                 795                 800

 aaa cat cat tat gtg ctc ctg gaa gga aga aaa cgc cac gat gct cac     2448
 Lys His His Tyr Val Leu Leu Glu Gly Arg Lys Arg His Asp Ala His
                 805                 810                 815

 caa acc cca ctc ctt ttt ctg cct ggg cac ata gga aaa gaa att ctg     2496
 Gln Thr Pro Leu Leu Phe Leu Pro Gly His Ile Gly Lys Glu Ile Leu
             820                 825                 830

 cag gct ccc ttg cag gag aca gta tct gta gga aac aaa gat aaa tgt     2544
 Gln Ala Pro Leu Gln Glu Thr Val Ser Val Gly Asn Lys Asp Lys Cys
         835                 840                 845

 gga aat cgg cag gtc ttc aaa aaa gag acc tca tct gct cag agt tta     2592
 Gly Asn Arg Gln Val Phe Lys Lys Glu Thr Ser Ser Ala Gln Ser Leu
     850                 855                 860

 tca tca gct att gaa atc agg caa atg tta gca cta cga gct cct cgg     2640
 Ser Ser Ala Ile Glu Ile Arg Gln Met Leu Ala Leu Arg Ala Pro Arg
 865                 870                 875                 880

 aag gct att gaa gtc tgc ctc att cac ctc ttc cag ctc caa ggg acc     2688
 Lys Ala Ile Glu Val Cys Leu Ile His Leu Phe Gln Leu Gln Gly Thr
                 885                 890                 895

 aaa caa caa acc tct cga gct gta gta aac gaa gag tgt ctc tca ggt     2736
 Lys Gln Gln Thr Ser Arg Ala Val Val Asn Glu Glu Cys Leu Ser Gly
             900                 905                 910

 cct ctg aga gaa ggt gga gca gtt tct tct acc tca tgg aaa ctg ctg     2784
 Pro Leu Arg Glu Gly Gly Ala Val Ser Ser Thr Ser Trp Lys Leu Leu
         915                 920                 925

 aag agt caa gga ttc aaa ctg tca tcc tct gat tca tag                 2823
 Lys Ser Gln Gly Phe Lys Leu Ser Ser Ser Asp Ser 
     930                 935                 940





      <210> 602
      <211> 1326
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (1)..(1326)

      <400> 602
  atg ccc atg cgg ggc tgc cta cgc acg gtg ctc ggg cta cct cca tgg      48
  Met Pro Met Arg Gly Cys Leu Arg Thr Val Leu Gly Leu Pro Pro Trp
    1               5                  10                  15

 ggt gct cag aat gcc cat gca ggg atg cct aca cgg ggt gct cag gat       96
 Gly Ala Gln Asn Ala His Ala Gly Met Pro Thr Arg Gly Ala Gln Asp
              20                  25                  30

 gtt tat gcg ggg atg cct aca cgg ggt gct cag gat gtt tat gcg ggg      144
 Val Tyr Ala Gly Met Pro Thr Arg Gly Ala Gln Asp Val Tyr Ala Gly
          35                  40                  45

 atg cct aca cgg ggt gct cag gat gtt tat gcg ggg atg cct aca cgg      192
 Met Pro Thr Arg Gly Ala Gln Asp Val Tyr Ala Gly Met Pro Thr Arg
      50                  55                  60

 ggt gct cag gat gtt tat gcg ggg atg cct aca tgg ggt gct cag gat      240
 Gly Ala Gln Asp Val Tyr Ala Gly Met Pro Thr Trp Gly Ala Gln Asp
  65                  70                  75                  80

 gtt tat gcg ggg atg cct acc tgg gga ttc ctg gga tgc cta tgc ggg      288
 Val Tyr Ala Gly Met Pro Thr Trp Gly Phe Leu Gly Cys Leu Cys Gly
                  85                  90                  95

 atg tct gcg ggt gtt cgg gat gcc tcc acg gga ctg cct aca cat ggt      336
 Met Ser Ala Gly Val Arg Asp Ala Ser Thr Gly Leu Pro Thr His Gly
             100                 105                 110

 gct cgg ggt gcc tac agg ggg atg ccc aca tgg gtg ctc ggg atg cct      384
 Ala Arg Gly Ala Tyr Arg Gly Met Pro Thr Trp Val Leu Gly Met Pro
         115                 120                 125

 act ggg aga tgc cca cgc agg gct gcc cgg gat gcc tgt aac tct aga      432
 Thr Gly Arg Cys Pro Arg Arg Ala Ala Arg Asp Ala Cys Asn Ser Arg
     130                 135                 140

 gga aag cgt cta cag cat tgc tat ttc tct ggc aca acg tta cag tgt      480
 Gly Lys Arg Leu Gln His Cys Tyr Phe Ser Gly Thr Thr Leu Gln Cys
 145                 150                 155                 160

 ctc ccg ctg gga agt ttt tat gac cca ttt gga gtt cct ctt cac gga      528
 Leu Pro Leu Gly Ser Phe Tyr Asp Pro Phe Gly Val Pro Leu His Gly
                 165                 170                 175

 cag tgg tca gaa acg cct gat agt ggc aca aaa cat aaa cag gaa aat      576
 Gln Trp Ser Glu Thr Pro Asp Ser Gly Thr Lys His Lys Gln Glu Asn
             180                 185                 190

 gca ttt tgt ttg tcc aca cta gaa att gaa aat aga gcc caa gac ctt      624
 Ala Phe Cys Leu Ser Thr Leu Glu Ile Glu Asn Arg Ala Gln Asp Leu
         195                 200                 205

 cat ctc ttt gag act ttg aag act gat cca gaa gcc ttt cac cag cac      672
 His Leu Phe Glu Thr Leu Lys Thr Asp Pro Glu Ala Phe His Gln His
     210                 215                 220

 atg gtc aag tat att tac cct act att ggt ggc ttt gat cac gaa agg      720
 Met Val Lys Tyr Ile Tyr Pro Thr Ile Gly Gly Phe Asp His Glu Arg
 225                 230                 235                 240

 ctg cag tat tat ttc act ctt ctg gaa aac tgt ggc tgt gca gat ttg      768
 Leu Gln Tyr Tyr Phe Thr Leu Leu Glu Asn Cys Gly Cys Ala Asp Leu
                 245                 250                 255

 ggg aac tgt gcc att aaa cca gaa acc cac att cga ctg ctg aag aag      816
 Gly Asn Cys Ala Ile Lys Pro Glu Thr His Ile Arg Leu Leu Lys Lys
             260                 265                 270

 ttt aag gtt gtt gca tca ggt ctt aat tac aaa aag ctg aca gat gaa      864
 Phe Lys Val Val Ala Ser Gly Leu Asn Tyr Lys Lys Leu Thr Asp Glu
         275                 280                 285

 aac atg agt cct ctt gaa gca ttg gag cca gtt ctt tca agt caa aat      912
 Asn Met Ser Pro Leu Glu Ala Leu Glu Pro Val Leu Ser Ser Gln Asn
     290                 295                 300

 atc ttg tct att tcc aaa ctt gtt ccc aaa atc cct gaa aag gat gga      960
 Ile Leu Ser Ile Ser Lys Leu Val Pro Lys Ile Pro Glu Lys Asp Gly
 305                 310                 315                 320

 cag atg ctt tcc cca agc tct ctg tac acc atc tgg tta cag aag ttg     1008
 Gln Met Leu Ser Pro Ser Ser Leu Tyr Thr Ile Trp Leu Gln Lys Leu
                 325                 330                 335

 ttc tgg act gga gac cct cat ctc att aaa caa gtc cca ggc tct tca     1056
 Phe Trp Thr Gly Asp Pro His Leu Ile Lys Gln Val Pro Gly Ser Ser
             340                 345                 350

 ccg gag tgg ctt cat gcc tat gat gtc tgc atg aag tac ttt gat cgt     1104
 Pro Glu Trp Leu His Ala Tyr Asp Val Cys Met Lys Tyr Phe Asp Arg
         355                 360                 365

 ctc cac cca ggt gac ctc atc act gtg gta gat gca gtt aca ttt tct     1152
 Leu His Pro Gly Asp Leu Ile Thr Val Val Asp Ala Val Thr Phe Ser
     370                 375                 380

 cca aaa gct gtg acc aag tgc cta ctg ctt cat caa gta gtg gca ccc     1200
 Pro Lys Ala Val Thr Lys Cys Leu Leu Leu His Gln Val Val Ala Pro
 385                 390                 395                 400

 ata gga tgt aaa att gca gct atc gca gga tgt cga ctt gac agc cag     1248
 Ile Gly Cys Lys Ile Ala Ala Ile Ala Gly Cys Arg Leu Asp Ser Gln
                 405                 410                 415

 gga gat ctc ttc ata aat ggg gat ggt aaa caa ata act cag tta aag     1296
 Gly Asp Leu Phe Ile Asn Gly Asp Gly Lys Gln Ile Thr Gln Leu Lys
             420                 425                 430

 atg tgg agg cag aaa ggt aga aat ggt taa                             1326
 Met Trp Arg Gln Lys Gly Arg Asn Gly 
         435                 440





      <210> 603
      <211> 1554
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (1)..(1554)

      <400> 603
  atg atg ctt ttt att aat gct aac tgc tta tgt ttc cat agt gtc tat      48
  Met Met Leu Phe Ile Asn Ala Asn Cys Leu Cys Phe His Ser Val Tyr
    1               5                  10                  15

 gtc tgg gcc aag atc cta gca aca tta att atc gta aca gga ttt caa       96
 Val Trp Ala Lys Ile Leu Ala Thr Leu Ile Ile Val Thr Gly Phe Gln
              20                  25                  30

 ctt ttt cat cta tca gag gta gca gta gaa act aac ttc cta agt gga      144
 Leu Phe His Leu Ser Glu Val Ala Val Glu Thr Asn Phe Leu Ser Gly
          35                  40                  45

 atg cat aaa gaa ttg cca ttt ctt cag ttt ttc aga aaa cct gtc att      192
 Met His Lys Glu Leu Pro Phe Leu Gln Phe Phe Arg Lys Pro Val Ile
      50                  55                  60

 tac tcc atc ctt tat agt gat gct aca gga cga aga gga atg gat aaa      240
 Tyr Ser Ile Leu Tyr Ser Asp Ala Thr Gly Arg Arg Gly Met Asp Lys
  65                  70                  75                  80

 aac att ggc gag caa ctc aat aaa gcg tat gaa gcc ttc cgg cag gca      288
 Asn Ile Gly Glu Gln Leu Asn Lys Ala Tyr Glu Ala Phe Arg Gln Ala
                  85                  90                  95

 tgc atg gat aga gat tct gca gta aaa gaa tta cag caa aag tca cat      336
 Cys Met Asp Arg Asp Ser Ala Val Lys Glu Leu Gln Gln Lys Ser His
             100                 105                 110

 gat acc ttc cac tat atg gaa gat gct agt gtc ttg gtt ttg gac ttg      384
 Asp Thr Phe His Tyr Met Glu Asp Ala Ser Val Leu Val Leu Asp Leu
         115                 120                 125

 cca gat act ggt gtc tta gtt ttg gat ttc cca gca tcc aga act act      432
 Pro Asp Thr Gly Val Leu Val Leu Asp Phe Pro Ala Ser Arg Thr Thr
     130                 135                 140

 gag aac tat gag cag aga ata cgt gaa caa cag gaa cag ctg tca ctt      480
 Glu Asn Tyr Glu Gln Arg Ile Arg Glu Gln Gln Glu Gln Leu Ser Leu
 145                 150                 155                 160

 caa cag act att att gac aag cta aaa tct cag tta ctt ctt gtg aat      528
 Gln Gln Thr Ile Ile Asp Lys Leu Lys Ser Gln Leu Leu Leu Val Asn
                 165                 170                 175

 tcc act caa gat aac aat tat ggc tgt gtt cct ctg ctt gaa gac agt      576
 Ser Thr Gln Asp Asn Asn Tyr Gly Cys Val Pro Leu Leu Glu Asp Ser
             180                 185                 190

 gaa aca aga aag aat aat ttg act ctt gat cag cca caa gat aaa gtg      624
 Glu Thr Arg Lys Asn Asn Leu Thr Leu Asp Gln Pro Gln Asp Lys Val
         195                 200                 205

 att tca gga ata gca aga gaa aaa cta cca aag gca gtg aac ttg att      672
 Ile Ser Gly Ile Ala Arg Glu Lys Leu Pro Lys Ala Val Asn Leu Ile
     210                 215                 220

 agc tca ggg ggt aat ata gag aag act ttc tgg gat ctg aaa gaa gaa      720
 Ser Ser Gly Gly Asn Ile Glu Lys Thr Phe Trp Asp Leu Lys Glu Glu
 225                 230                 235                 240

 ttt cat aaa ata tgc atg cta gca aaa gca cag aaa gac cac tta agc      768
 Phe His Lys Ile Cys Met Leu Ala Lys Ala Gln Lys Asp His Leu Ser
                 245                 250                 255

 aaa ctt aat ata cca gac act gca act gaa aca cag tgc tct gtg cct      816
 Lys Leu Asn Ile Pro Asp Thr Ala Thr Glu Thr Gln Cys Ser Val Pro
             260                 265                 270

 ata cag tgt acg gat aaa aca gat aaa caa gaa gcg ctg ttt aag cct      864
 Ile Gln Cys Thr Asp Lys Thr Asp Lys Gln Glu Ala Leu Phe Lys Pro
         275                 280                 285

 cag gct aaa gat gat ata aat aga ggt gca cca tcc atc aca tct gtc      912
 Gln Ala Lys Asp Asp Ile Asn Arg Gly Ala Pro Ser Ile Thr Ser Val
     290                 295                 300

 aca cca aga gga ctg tgc aga gat gag gaa gac acc tct ttt gaa tca      960
 Thr Pro Arg Gly Leu Cys Arg Asp Glu Glu Asp Thr Ser Phe Glu Ser
 305                 310                 315                 320

 ctt tct aaa ttc aat gtc aag ttt cca cct atg gac aat gac tca act     1008
 Leu Ser Lys Phe Asn Val Lys Phe Pro Pro Met Asp Asn Asp Ser Thr
                 325                 330                 335

 ttc tta cat agc act cca gag aga ccc ggc atc ctt agt cct gcc acg     1056
 Phe Leu His Ser Thr Pro Glu Arg Pro Gly Ile Leu Ser Pro Ala Thr
             340                 345                 350

 tct gag gca gtg tgc caa gag aaa ttt aat atg gag ttc aga gac aac     1104
 Ser Glu Ala Val Cys Gln Glu Lys Phe Asn Met Glu Phe Arg Asp Asn
         355                 360                 365

 cca ggg aac ttt gtt aaa aca gaa gaa act tta ttt gaa att cag gga     1152
 Pro Gly Asn Phe Val Lys Thr Glu Glu Thr Leu Phe Glu Ile Gln Gly
     370                 375                 380

 att gac ccc ata gct tca gct ata caa aac ctt aaa aca act gac aaa     1200
 Ile Asp Pro Ile Ala Ser Ala Ile Gln Asn Leu Lys Thr Thr Asp Lys
 385                 390                 395                 400

 aca aag ccc tca aat ctc gta aac act tgt atc agg aca act ctg gat     1248
 Thr Lys Pro Ser Asn Leu Val Asn Thr Cys Ile Arg Thr Thr Leu Asp
                 405                 410                 415

 aga gct gcg tgt ttg cca cct gga gac cat aat gca tta tat gta aat     1296
 Arg Ala Ala Cys Leu Pro Pro Gly Asp His Asn Ala Leu Tyr Val Asn
             420                 425                 430

 agc ttc cca ctt ctg gac cca tct gat gca cct ttt ccc tca ctc gat     1344
 Ser Phe Pro Leu Leu Asp Pro Ser Asp Ala Pro Phe Pro Ser Leu Asp
         435                 440                 445

 tcc ccg gga aaa gca atc cga gga cca cag cag ccc att tgg aag ccc     1392
 Ser Pro Gly Lys Ala Ile Arg Gly Pro Gln Gln Pro Ile Trp Lys Pro
     450                 455                 460

 ttt cct aat caa gac agt gac tcg gtg gta cta agt ggc aca gac tca     1440
 Phe Pro Asn Gln Asp Ser Asp Ser Val Val Leu Ser Gly Thr Asp Ser
 465                 470                 475                 480

 gaa ctg cat ata cct cga gta tgt gaa ttc tgt caa gca gtt ttc cca     1488
 Glu Leu His Ile Pro Arg Val Cys Glu Phe Cys Gln Ala Val Phe Pro
                 485                 490                 495

 cca tcc att aca tcc agg ggg gat ttc ctt cgg cat ctt aat tca cac     1536
 Pro Ser Ile Thr Ser Arg Gly Asp Phe Leu Arg His Leu Asn Ser His
             500                 505                 510

 ttc aat gga gag act taa                                             1554
 Phe Asn Gly Glu Thr 
         515





      <210> 604
      <211> 738
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (1)..(738)

      <400> 604
  atg aag ttg gta ctg ttc ctg tcc cta cta aag aca ggg aca ctg ggg      48
  Met Lys Leu Val Leu Phe Leu Ser Leu Leu Lys Thr Gly Thr Leu Gly
    1               5                  10                  15

 caa aga gat gac caa gag cta ggt gaa gcc tgc tcc aga gac caa cca       96
 Gln Arg Asp Asp Gln Glu Leu Gly Glu Ala Cys Ser Arg Asp Gln Pro
              20                  25                  30

 cac cct gtc cac gcc cca gag aag gtc agt gca cca gat att ctg aaa      144
 His Pro Val His Ala Pro Glu Lys Val Ser Ala Pro Asp Ile Leu Lys
          35                  40                  45

 cct ctc aat caa gag gat ccc aaa tgc tct act aac cct att ttg aag      192
 Pro Leu Asn Gln Glu Asp Pro Lys Cys Ser Thr Asn Pro Ile Leu Lys
      50                  55                  60

 caa cag aat ctc cca tcc agt ccg gca ccc agt acc ata ttc tct gga      240
 Gln Gln Asn Leu Pro Ser Ser Pro Ala Pro Ser Thr Ile Phe Ser Gly
  65                  70                  75                  80

 ggt ttt aga cac cac aag gac aag act gaa gtc tct ata gta aag gtg      288
 Gly Phe Arg His His Lys Asp Lys Thr Glu Val Ser Ile Val Lys Val
                  85                  90                  95

 aaa aac cta agg caa acg ata gca atg aag aca agg tat caa aat ata      336
 Lys Asn Leu Arg Gln Thr Ile Ala Met Lys Thr Arg Tyr Gln Asn Ile
             100                 105                 110

 aat gcc tgg cta aaa tgg att aaa tat tcc atc cgc act cta aat aaa      384
 Asn Ala Trp Leu Lys Trp Ile Lys Tyr Ser Ile Arg Thr Leu Asn Lys
         115                 120                 125

 agc gac tgt tac gcg tgt gcg cac ggt agg cca gag gcc cag ctt gtc      432
 Ser Asp Cys Tyr Ala Cys Ala His Gly Arg Pro Glu Ala Gln Leu Val
     130                 135                 140

 ccc ttt cca ctc gga cag tcc tct aat cga caa gac gta gac tgc ata      480
 Pro Phe Pro Leu Gly Gln Ser Ser Asn Arg Gln Asp Val Asp Cys Ile
 145                 150                 155                 160

 att gac ttt ctt tca aac cca gac tgt gcc aat ggc ttt aat aaa agt      528
 Ile Asp Phe Leu Ser Asn Pro Asp Cys Ala Asn Gly Phe Asn Lys Ser
                 165                 170                 175

 cag gct gag ttt tgg gtt gcg ctt ctg ggc cag aat ctt ttg gtt gac      576
 Gln Ala Glu Phe Trp Val Ala Leu Leu Gly Gln Asn Leu Leu Val Asp
             180                 185                 190

 tcc att tgc tgc att caa ctt gta acc tgc tca aag gct ctg ttc tgg      624
 Ser Ile Cys Cys Ile Gln Leu Val Thr Cys Ser Lys Ala Leu Phe Trp
         195                 200                 205

 ctc cag aga gag cag aac cag gag ccc tgc cag ggc gat ggt ggt gga      672
 Leu Gln Arg Glu Gln Asn Gln Glu Pro Cys Gln Gly Asp Gly Gly Gly
     210                 215                 220

 gcc atg agt cgc ctg gga agg aac gca ttt gat gga tgg acg tgc tct      720
 Ala Met Ser Arg Leu Gly Arg Asn Ala Phe Asp Gly Trp Thr Cys Ser
 225                 230                 235                 240

 gct ctc ctt tca tta tga                                              738
 Ala Leu Leu Ser Leu 
                 245





      <210> 605
      <211> 1467
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (1)..(1467)

      <400> 605
  atg ggg ttt cgc cat gtt ggc cag gct ggt ctt gaa ctc ctg acc tca      48
  Met Gly Phe Arg His Val Gly Gln Ala Gly Leu Glu Leu Leu Thr Ser
    1               5                  10                  15

 ggt cta ggg ctg gta aca gct tca ggt tat tgc act att tct tgg ggt       96
 Gly Leu Gly Leu Val Thr Ala Ser Gly Tyr Cys Thr Ile Ser Trp Gly
              20                  25                  30

 tcc cca tgc acc tgt gcc ttt ggg aat ggt ccc ata gac ggt cac tcg      144
 Ser Pro Cys Thr Cys Ala Phe Gly Asn Gly Pro Ile Asp Gly His Ser
          35                  40                  45

 ctg agc atc atc tta gaa atg ggg ctg tgc act atg aag act aaa caa      192
 Leu Ser Ile Ile Leu Glu Met Gly Leu Cys Thr Met Lys Thr Lys Gln
      50                  55                  60

 gag ttc cag gac tgg acc aaa aga agt gtg gaa ctt gag ggt ggg aat      240
 Glu Phe Gln Asp Trp Thr Lys Arg Ser Val Glu Leu Glu Gly Gly Asn
  65                  70                  75                  80

 gcc tca tca gaa ctt caa agc ttc caa ggc cat cac aac aag gag ggt      288
 Ala Ser Ser Glu Leu Gln Ser Phe Gln Gly His His Asn Lys Glu Gly
                  85                  90                  95

 ctg aga aac tgt cgc agc cag gag gag ccc gag gag atg ctc ccg acc      336
 Leu Arg Asn Cys Arg Ser Gln Glu Glu Pro Glu Glu Met Leu Pro Thr
             100                 105                 110

 atc atg tgg aat cct gga cgg gat cca gta gaa gac tca gaa agt ggt      384
 Ile Met Trp Asn Pro Gly Arg Asp Pro Val Glu Asp Ser Glu Ser Gly
         115                 120                 125

 gtt tac atg cga ttc atg agg tca cac aag tgt tat gac atc gtt cca      432
 Val Tyr Met Arg Phe Met Arg Ser His Lys Cys Tyr Asp Ile Val Pro
     130                 135                 140

 acc agt tca aag ctt gtt gtc ttt gat act aca tta caa gtt aaa aag      480
 Thr Ser Ser Lys Leu Val Val Phe Asp Thr Thr Leu Gln Val Lys Lys
 145                 150                 155                 160

 gcc ttc ttt gct ttg gta gcc aac ggt gtc cga gca gcg cca ctg tgg      528
 Ala Phe Phe Ala Leu Val Ala Asn Gly Val Arg Ala Ala Pro Leu Trp
                 165                 170                 175

 gag agt aaa aaa caa agt ttt gta gag ctt tat tta caa gaa aca ttt      576
 Glu Ser Lys Lys Gln Ser Phe Val Glu Leu Tyr Leu Gln Glu Thr Phe
             180                 185                 190

 aag cct tta gtg aat ata tct cca gat gca agc ctc ttc gat gct gta      624
 Lys Pro Leu Val Asn Ile Ser Pro Asp Ala Ser Leu Phe Asp Ala Val
         195                 200                 205

 tac tcc ttg atc aaa aat aaa atc cac aga ttg ccc gtt att gac cct      672
 Tyr Ser Leu Ile Lys Asn Lys Ile His Arg Leu Pro Val Ile Asp Pro
     210                 215                 220

 atc agt ggg aat gca ctt tat ata ctt acc cac aaa aga atc ctc aag      720
 Ile Ser Gly Asn Ala Leu Tyr Ile Leu Thr His Lys Arg Ile Leu Lys
 225                 230                 235                 240

 ttc ctc cag ctt ttt atg tct gat atg cca aag cct gcc ttc atg aag      768
 Phe Leu Gln Leu Phe Met Ser Asp Met Pro Lys Pro Ala Phe Met Lys
                 245                 250                 255

 cag aac ctg gat gag ctt gga ata gga acg tac cac aac att gcc ttc      816
 Gln Asn Leu Asp Glu Leu Gly Ile Gly Thr Tyr His Asn Ile Ala Phe
             260                 265                 270

 ata cat cca gac act ccc atc atc aaa gcc ttg aac ata ttt gtg gaa      864
 Ile His Pro Asp Thr Pro Ile Ile Lys Ala Leu Asn Ile Phe Val Glu
         275                 280                 285

 aga cga ata tca gct ctg cct gtt gtg gat gag tca gga aaa gtt gta      912
 Arg Arg Ile Ser Ala Leu Pro Val Val Asp Glu Ser Gly Lys Val Val
     290                 295                 300

 gat att tat tcc aaa ttt gat gta att aat ctt gct gct gag aaa aca      960
 Asp Ile Tyr Ser Lys Phe Asp Val Ile Asn Leu Ala Ala Glu Lys Thr
 305                 310                 315                 320

 tac aat aac cta gat atc acg gtg acc cag gcc ctt cag cac cgt tca     1008
 Tyr Asn Asn Leu Asp Ile Thr Val Thr Gln Ala Leu Gln His Arg Ser
                 325                 330                 335

 cag tat ttt gaa ggt gtt gtg aag tgc aat aag ctg gaa ata ctg gag     1056
 Gln Tyr Phe Glu Gly Val Val Lys Cys Asn Lys Leu Glu Ile Leu Glu
             340                 345                 350

 acc atc gtg gac aga ata gta aga gct gag gtc cat cgg ctg gtg gtg     1104
 Thr Ile Val Asp Arg Ile Val Arg Ala Glu Val His Arg Leu Val Val
         355                 360                 365

 gta aat gaa gca gat agt att gtg ggt att att tcc ctg tcg gac att     1152
 Val Asn Glu Ala Asp Ser Ile Val Gly Ile Ile Ser Leu Ser Asp Ile
     370                 375                 380

 ctg caa gcc ctg atc ctc aca cca gca gcc cca gtc aaa tat gaa caa     1200
 Leu Gln Ala Leu Ile Leu Thr Pro Ala Ala Pro Val Lys Tyr Glu Gln
 385                 390                 395                 400

 ccc agc ctt tgt cag ggc cac atg gac ccg atg tgg gag caa aca gca     1248
 Pro Ser Leu Cys Gln Gly His Met Asp Pro Met Trp Glu Gln Thr Ala
                 405                 410                 415

 tgc cct ttg aac tct cag aat cca ata tta aac gaa ttc act ggt atg     1296
 Cys Pro Leu Asn Ser Gln Asn Pro Ile Leu Asn Glu Phe Thr Gly Met
             420                 425                 430

 gaa cag gtg atg tgg cat aag gtg agt gca cgg tat gtt cag atc aca     1344
 Glu Gln Val Met Trp His Lys Val Ser Ala Arg Tyr Val Gln Ile Thr
         435                 440                 445

 gtg cct tat gtc cga ata cag caa tat gtc acc gcc gca gcc ggg gcg     1392
 Val Pro Tyr Val Arg Ile Gln Gln Tyr Val Thr Ala Ala Ala Gly Ala
     450                 455                 460

 cac gcg tgt gaa aca aca ccg agc ttg aat gtg gaa gtc ttt gaa cct     1440
 His Ala Cys Glu Thr Thr Pro Ser Leu Asn Val Glu Val Phe Glu Pro
 465                 470                 475                 480

 ttt acc aaa tca gtt tgt ttt ctt tag                                 1467
 Phe Thr Lys Ser Val Cys Phe Leu 
                 485





      <210> 606
      <211> 3372
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (1)..(3372)

      <400> 606
  atg ctg cag cag ctc ctg atc acc ctg ccc acc gag gcc agc acc tgg      48
  Met Leu Gln Gln Leu Leu Ile Thr Leu Pro Thr Glu Ala Ser Thr Trp
    1               5                  10                  15

 gtg aag ttg cgt cat cca aag gcg gcc acg gag cgg gtg gcc ctg tgg       96
 Val Lys Leu Arg His Pro Lys Ala Ala Thr Glu Arg Val Ala Leu Trp
              20                  25                  30

 gag gat gtg act aag atg ttt aaa gca gaa gct ctg ctg tct cag gat      144
 Glu Asp Val Thr Lys Met Phe Lys Ala Glu Ala Leu Leu Ser Gln Asp
          35                  40                  45

 gct gat gag acc cag ggc gaa agt tta gag agt aga gtg acc ctt gga      192
 Ala Asp Glu Thr Gln Gly Glu Ser Leu Glu Ser Arg Val Thr Leu Gly
      50                  55                  60

 tcc ctg aca gca gaa tcc cag gaa ctg tta acc ttc aag gac gta tct      240
 Ser Leu Thr Ala Glu Ser Gln Glu Leu Leu Thr Phe Lys Asp Val Ser
  65                  70                  75                  80

 gtg gac ttc act cag gag gag tgg ggg cag ctg gcc cct gct cac cgg      288
 Val Asp Phe Thr Gln Glu Glu Trp Gly Gln Leu Ala Pro Ala His Arg
                  85                  90                  95

 aat ctg tac cgg gag gtg atg ctg gag aac tat ggg aac ctg gtc tca      336
 Asn Leu Tyr Arg Glu Val Met Leu Glu Asn Tyr Gly Asn Leu Val Ser
             100                 105                 110

 gtg gga tgt cag ctt tcc aaa cct ggc gtg att tcc cag ttg gag aaa      384
 Val Gly Cys Gln Leu Ser Lys Pro Gly Val Ile Ser Gln Leu Glu Lys
         115                 120                 125

 gga gaa gaa cca tgg ctg atg gag aga gat att tca gga gtt cca agt      432
 Gly Glu Glu Pro Trp Leu Met Glu Arg Asp Ile Ser Gly Val Pro Ser
     130                 135                 140

 tca gac ttg aag agc aaa aca aaa acc aaa gag tca gcc tta cag aat      480
 Ser Asp Leu Lys Ser Lys Thr Lys Thr Lys Glu Ser Ala Leu Gln Asn
 145                 150                 155                 160

 gat att tcg tgg gaa gaa cta cat tgt ggc cta atg atg gaa aga ttt      528
 Asp Ile Ser Trp Glu Glu Leu His Cys Gly Leu Met Met Glu Arg Phe
                 165                 170                 175

 aca aaa gga agc agc atg tat tcc acc ttg gga aga atc tcc aaa tgt      576
 Thr Lys Gly Ser Ser Met Tyr Ser Thr Leu Gly Arg Ile Ser Lys Cys
             180                 185                 190

 aat aag cta gaa agc caa caa gag aac caa aga atg ggt aag ggg caa      624
 Asn Lys Leu Glu Ser Gln Gln Glu Asn Gln Arg Met Gly Lys Gly Gln
         195                 200                 205

 atc ccc ctg atg tgc aag aaa aca ttc act cag gag aga ggc caa gag      672
 Ile Pro Leu Met Cys Lys Lys Thr Phe Thr Gln Glu Arg Gly Gln Glu
     210                 215                 220

 tct aat aga ttt gag aaa aga att aat gtg aag tca gaa gtt atg cca      720
 Ser Asn Arg Phe Glu Lys Arg Ile Asn Val Lys Ser Glu Val Met Pro
 225                 230                 235                 240

 gga cca ata ggt ctt cca aga aaa aga gat cgt aaa tat gac aca cct      768
 Gly Pro Ile Gly Leu Pro Arg Lys Arg Asp Arg Lys Tyr Asp Thr Pro
                 245                 250                 255

 gga aag aga agc aga tac aac ata gat tta gtt aat cat tca agg agt      816
 Gly Lys Arg Ser Arg Tyr Asn Ile Asp Leu Val Asn His Ser Arg Ser
             260                 265                 270

 tat aca aaa atg aaa acc ttt gag tgt aat att tgt gaa aaa atc ttc      864
 Tyr Thr Lys Met Lys Thr Phe Glu Cys Asn Ile Cys Glu Lys Ile Phe
         275                 280                 285

 aaa cag ctt att cac ctt act gaa cac atg aga att cat acc ggg gag      912
 Lys Gln Leu Ile His Leu Thr Glu His Met Arg Ile His Thr Gly Glu
     290                 295                 300

 aaa cct ttc aga tgt aag gaa tgt gga aaa gcc ttt agc caa agt tca      960
 Lys Pro Phe Arg Cys Lys Glu Cys Gly Lys Ala Phe Ser Gln Ser Ser
 305                 310                 315                 320

 tct ctt att ccg cat cag aga att cat act ggt gag aaa ccc tat gaa     1008
 Ser Leu Ile Pro His Gln Arg Ile His Thr Gly Glu Lys Pro Tyr Glu
                 325                 330                 335

 tgt aag gag tgt ggg aaa acc ttc aga cat cct tca tcg ctt act caa     1056
 Cys Lys Glu Cys Gly Lys Thr Phe Arg His Pro Ser Ser Leu Thr Gln
             340                 345                 350

 cat gtt aga att cat acc ggg gaa aag ccc tat gaa tgt agg gta tgt     1104
 His Val Arg Ile His Thr Gly Glu Lys Pro Tyr Glu Cys Arg Val Cys
         355                 360                 365

 gag aaa gcc ttc agc cag agc att gga ctg atc cag cat ttg aga act     1152
 Glu Lys Ala Phe Ser Gln Ser Ile Gly Leu Ile Gln His Leu Arg Thr
     370                 375                 380

 cat gtt aga gag aaa cct ttt aca tgc aaa gac tgt gga aaa gcg ttt     1200
 His Val Arg Glu Lys Pro Phe Thr Cys Lys Asp Cys Gly Lys Ala Phe
 385                 390                 395                 400

 ttc cag att aga cac ctt agg caa cat gag att att cat act ggt gtg     1248
 Phe Gln Ile Arg His Leu Arg Gln His Glu Ile Ile His Thr Gly Val
                 405                 410                 415

 aaa ccc tat att tgt aat gta tgt agt aaa acc ttc agc cat agt aca     1296
 Lys Pro Tyr Ile Cys Asn Val Cys Ser Lys Thr Phe Ser His Ser Thr
             420                 425                 430

 tac cta act caa cac cag aga act cat act gga gaa aga cca tat aaa     1344
 Tyr Leu Thr Gln His Gln Arg Thr His Thr Gly Glu Arg Pro Tyr Lys
         435                 440                 445

 tgt aag gaa tgt ggg aaa gcc ttt agc cag aga ata cat ctt tct atc     1392
 Cys Lys Glu Cys Gly Lys Ala Phe Ser Gln Arg Ile His Leu Ser Ile
     450                 455                 460

 cat cag aga gtc cat act gga gta aaa cct tat gaa tgc agt cat tgt     1440
 His Gln Arg Val His Thr Gly Val Lys Pro Tyr Glu Cys Ser His Cys
 465                 470                 475                 480

 ggg aaa gcc ttt agg cat gat tca tcc ttt gct aaa cat cag aga att     1488
 Gly Lys Ala Phe Arg His Asp Ser Ser Phe Ala Lys His Gln Arg Ile
                 485                 490                 495

 cat act gga gaa aaa cct tat gat tgt aat gag tgt gga aaa gcc ttc     1536
 His Thr Gly Glu Lys Pro Tyr Asp Cys Asn Glu Cys Gly Lys Ala Phe
             500                 505                 510

 agc tgt agt tca tcc ctt att aga cac tgc aaa aca cat tta aga aat     1584
 Ser Cys Ser Ser Ser Leu Ile Arg His Cys Lys Thr His Leu Arg Asn
         515                 520                 525

 acc ttc agc aat gtt cat aca aca tta gat ttg aaa tat gct ttg tat     1632
 Thr Phe Ser Asn Val His Thr Thr Leu Asp Leu Lys Tyr Ala Leu Tyr
     530                 535                 540

 caa gtg gaa gtg tct ctt aag ata gcc cct aga aca aca cat caa gag     1680
 Gln Val Glu Val Ser Leu Lys Ile Ala Pro Arg Thr Thr His Gln Glu
 545                 550                 555                 560

 gcc cac caa aga gga cca gag aaa gaa gtg gac aag tcc agt aag gca     1728
 Ala His Gln Arg Gly Pro Glu Lys Glu Val Asp Lys Ser Ser Lys Ala
                 565                 570                 575

 ggc atc atg cca cag cag ctc ctg atc acc ctg cct acc gag gcc agc     1776
 Gly Ile Met Pro Gln Gln Leu Leu Ile Thr Leu Pro Thr Glu Ala Ser
             580                 585                 590

 acc tgg gtg aag ctg caa cat cca aag aag gcc gtg gag ggg gcg ccc     1824
 Thr Trp Val Lys Leu Gln His Pro Lys Lys Ala Val Glu Gly Ala Pro
         595                 600                 605

 ctg tgg gag gat gtg act aaa atg ttt gaa gga gaa gct ctg ctg tct     1872
 Leu Trp Glu Asp Val Thr Lys Met Phe Glu Gly Glu Ala Leu Leu Ser
     610                 615                 620

 cag gat gct gag gac gta aag acc cag aga gaa agt tta gag gat gaa     1920
 Gln Asp Ala Glu Asp Val Lys Thr Gln Arg Glu Ser Leu Glu Asp Glu
 625                 630                 635                 640

 gtg acc cct gga ctc ccg aca gca gaa tcc cag att aga gat cca gac     1968
 Val Thr Pro Gly Leu Pro Thr Ala Glu Ser Gln Ile Arg Asp Pro Asp
                 645                 650                 655

 aga cta cag ttc cag aca gtt ttg ttg atc aga ttt gga gat cag agg     2016
 Arg Leu Gln Phe Gln Thr Val Leu Leu Ile Arg Phe Gly Asp Gln Arg
             660                 665                 670

 atc tcc aaa cag atc cag aga agg ctc ctg ata aaa gaa gag tgg ggg     2064
 Ile Ser Lys Gln Ile Gln Arg Arg Leu Leu Ile Lys Glu Glu Trp Gly
         675                 680                 685

 cag ctg gct cct gct cac cag aat cta tac cga gag gtg atg ctg gag     2112
 Gln Leu Ala Pro Ala His Gln Asn Leu Tyr Arg Glu Val Met Leu Glu
     690                 695                 700

 aac tac agc aac ttg gtg tca gtg gga tat caa ctt tcc aaa cct agt     2160
 Asn Tyr Ser Asn Leu Val Ser Val Gly Tyr Gln Leu Ser Lys Pro Ser
 705                 710                 715                 720

 gtg ata tcc cag tta gag aaa gga gaa gag cca tgg atg gca gag aaa     2208
 Val Ile Ser Gln Leu Glu Lys Gly Glu Glu Pro Trp Met Ala Glu Lys
                 725                 730                 735

 gaa ggc cca gga gat ccc agt tca gac ttg aag agt aaa ata gaa acc     2256
 Glu Gly Pro Gly Asp Pro Ser Ser Asp Leu Lys Ser Lys Ile Glu Thr
             740                 745                 750

 att gag tca act gca aag agt acc att tca cag gag cgc tta tat cat     2304
 Ile Glu Ser Thr Ala Lys Ser Thr Ile Ser Gln Glu Arg Leu Tyr His
         755                 760                 765

 ggc att atg atg gaa agt ttc atg agg gat gat ata att tat tcc acg     2352
 Gly Ile Met Met Glu Ser Phe Met Arg Asp Asp Ile Ile Tyr Ser Thr
     770                 775                 780

 ttg aga aaa gtc tcc aca tat gat gat gtc tta gaa agg cac cag gaa     2400
 Leu Arg Lys Val Ser Thr Tyr Asp Asp Val Leu Glu Arg His Gln Glu
 785                 790                 795                 800

 act tgt atg aga gat gtg aga caa gcc atc ttg acc cat aag aag aga     2448
 Thr Cys Met Arg Asp Val Arg Gln Ala Ile Leu Thr His Lys Lys Arg
                 805                 810                 815

 gtc caa gaa act aac aaa ttt ggg gaa aat atc att gtg cat tca aat     2496
 Val Gln Glu Thr Asn Lys Phe Gly Glu Asn Ile Ile Val His Ser Asn
             820                 825                 830

 gtt att att gaa cag agg cac cat aaa tat gat aca cct aca aag cgg     2544
 Val Ile Ile Glu Gln Arg His His Lys Tyr Asp Thr Pro Thr Lys Arg
         835                 840                 845

 aac aca tac aaa tta gat ttg att aat cat cca aca agt tac ata aga     2592
 Asn Thr Tyr Lys Leu Asp Leu Ile Asn His Pro Thr Ser Tyr Ile Arg
     850                 855                 860

 aca aaa acc tat gaa tgt aat ata tgt gaa aaa atc ttc aaa caa cct     2640
 Thr Lys Thr Tyr Glu Cys Asn Ile Cys Glu Lys Ile Phe Lys Gln Pro
 865                 870                 875                 880

 att cac ctt act gaa cat atg aga att cat act ggt gag aaa cct ttc     2688
 Ile His Leu Thr Glu His Met Arg Ile His Thr Gly Glu Lys Pro Phe
                 885                 890                 895

 aga tgt aag gaa tgt gga agg gcc ttt agt caa agt gca tcc ctc agt     2736
 Arg Cys Lys Glu Cys Gly Arg Ala Phe Ser Gln Ser Ala Ser Leu Ser
             900                 905                 910

 aca cac cag aga atc cat act ggt gag aaa ccc ttt gaa tgt gag gaa     2784
 Thr His Gln Arg Ile His Thr Gly Glu Lys Pro Phe Glu Cys Glu Glu
         915                 920                 925

 tgt ggg aaa gcc ttc aga cat cgc tca tca ctt aat cag cat cat aga     2832
 Cys Gly Lys Ala Phe Arg His Arg Ser Ser Leu Asn Gln His His Arg
     930                 935                 940

 act cac act ggg gag aaa ccc tat gta tgt gat aaa tgt cag aaa gct     2880
 Thr His Thr Gly Glu Lys Pro Tyr Val Cys Asp Lys Cys Gln Lys Ala
 945                 950                 955                 960

 ttc agc cag aac att agc ttg gtt caa cat ttg agg act cat tct gga     2928
 Phe Ser Gln Asn Ile Ser Leu Val Gln His Leu Arg Thr His Ser Gly
                 965                 970                 975

 gag aaa cct ttt act tgc aat gaa tgt ggg aaa acc ttt aga cag att     2976
 Glu Lys Pro Phe Thr Cys Asn Glu Cys Gly Lys Thr Phe Arg Gln Ile
             980                 985                 990

 aga cac ctt agt gaa cat ata aga att cat acc ggg gag aag ccc tat     3024
 Arg His Leu Ser Glu His Ile Arg Ile His Thr Gly Glu Lys Pro Tyr
         995                1000                1005

 gca tgc act gca tgt tgt aaa acc ttt agt cat aga gcg tat cta aca     3072
 Ala Cys Thr Ala Cys Cys Lys Thr Phe Ser His Arg Ala Tyr Leu Thr
    1010                1015                1020

 cat cac cag aga atc cat act ggg gag aga ccc tac aaa tgt aaa gaa     3120
 His His Gln Arg Ile His Thr Gly Glu Arg Pro Tyr Lys Cys Lys Glu
1025                1030                1035                1040

 tgt gga aaa gcc ttt agg cag agg ata cac ctt agc aac cat aaa act     3168
 Cys Gly Lys Ala Phe Arg Gln Arg Ile His Leu Ser Asn His Lys Thr
                1045                1050                1055

 gtt cat aca gga gtg aaa gca tat gaa tgc aac cgc tgt gga aaa gcc     3216
 Val His Thr Gly Val Lys Ala Tyr Glu Cys Asn Arg Cys Gly Lys Ala
            1060                1065                1070

 tat agg cat gat tca tcc ttt aaa aaa cat cag aga cat cac act gga     3264
 Tyr Arg His Asp Ser Ser Phe Lys Lys His Gln Arg His His Thr Gly
        1075                1080                1085

 gaa aaa cct tac gaa tgt aac gaa tgt gga aaa gcc ttc agc tat aac     3312
 Glu Lys Pro Tyr Glu Cys Asn Glu Cys Gly Lys Ala Phe Ser Tyr Asn
    1090                1095                1100

 tct tca ctt agt cga cat cat gaa ata cac agg agg aac gcc ttc cga     3360
 Ser Ser Leu Ser Arg His His Glu Ile His Arg Arg Asn Ala Phe Arg
1105                1110                1115                1120

 aat aag gtg taa                                                     3372
 Asn Lys Val 






      <210> 607
      <211> 513
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (1)..(513)

      <400> 607
  atg tct cgc tcc gtg gcc tta gct gtg ctc gcg cta ctc tct ctt tct      48
  Met Ser Arg Ser Val Ala Leu Ala Val Leu Ala Leu Leu Ser Leu Ser
    1               5                  10                  15

 ggc ctg gag gct atc cag cgt act cca aag att cag gtt tac tca cgt       96
 Gly Leu Glu Ala Ile Gln Arg Thr Pro Lys Ile Gln Val Tyr Ser Arg
              20                  25                  30

 cat cca gca gag aat gga aag tca aat ttc ctg aat tgc tat gtg tct      144
 His Pro Ala Glu Asn Gly Lys Ser Asn Phe Leu Asn Cys Tyr Val Ser
          35                  40                  45

 ggg ttt cat cca tcc gac att gaa gtt gac tta ctg aag aat gga gag      192
 Gly Phe His Pro Ser Asp Ile Glu Val Asp Leu Leu Lys Asn Gly Glu
      50                  55                  60

 aga att gaa aaa gtg gag cat tca gac ttg tct ttc agc aag gac tgg      240
 Arg Ile Glu Lys Val Glu His Ser Asp Leu Ser Phe Ser Lys Asp Trp
  65                  70                  75                  80

 tct ttc tat ctc ttg tac tac act gaa ttc acc ccc act gaa aaa gat      288
 Ser Phe Tyr Leu Leu Tyr Tyr Thr Glu Phe Thr Pro Thr Glu Lys Asp
                  85                  90                  95

 gag tat gcc tgc cgt gtg aac cat gtg act ttg tca cag ccc aag ata      336
 Glu Tyr Ala Cys Arg Val Asn His Val Thr Leu Ser Gln Pro Lys Ile
             100                 105                 110

 gtt aag tgg gct ttt gtg gca gct tca ggt ata ttt agc act gaa cga      384
 Val Lys Trp Ala Phe Val Ala Ala Ser Gly Ile Phe Ser Thr Glu Arg
         115                 120                 125

 aca tct caa gaa ggt ata ggc ctt tgt tta tcg aga cat gta agc agc      432
 Thr Ser Gln Glu Gly Ile Gly Leu Cys Leu Ser Arg His Val Ser Ser
     130                 135                 140

 atc atg gag aac agg gaa ttg att tgg gag agc atc agg aag gtg gat      480
 Ile Met Glu Asn Arg Glu Leu Ile Trp Glu Ser Ile Arg Lys Val Asp
 145                 150                 155                 160

 gat ctg ccc agt cac act gtt agt aaa ttg tag                          513
 Asp Leu Pro Ser His Thr Val Ser Lys Leu 
                 165                 170





      <210> 608
      <211> 708
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (1)..(708)

      <400> 608
  atg tgg aac tgt aag tcc aat aaa cct ctt tat ttt gta aat tgc cta      48
  Met Trp Asn Cys Lys Ser Asn Lys Pro Leu Tyr Phe Val Asn Cys Leu
    1               5                  10                  15

 gtc tca gct act tac att gct tac ctg cac tta cct tct gac ata gat       96
 Val Ser Ala Thr Tyr Ile Ala Tyr Leu His Leu Pro Ser Asp Ile Asp
              20                  25                  30

 gaa ata gta ctg gag aga gat aat gag gtt ccc aga gtg tgg aag aag      144
 Glu Ile Val Leu Glu Arg Asp Asn Glu Val Pro Arg Val Trp Lys Lys
          35                  40                  45

 gat tct tta gga gct aca cac ctt gag tgg gag gga gag ctt atg ggt      192
 Asp Ser Leu Gly Ala Thr His Leu Glu Trp Glu Gly Glu Leu Met Gly
      50                  55                  60

 caa atg aga aaa gaa tta gag aag caa gaa caa atc aaa ccc aaa gct      240
 Gln Met Arg Lys Glu Leu Glu Lys Gln Glu Gln Ile Lys Pro Lys Ala
  65                  70                  75                  80

 agc aga aga caa gaa ata acc aaa atc aga gct gaa ctg aag gaa atc      288
 Ser Arg Arg Gln Glu Ile Thr Lys Ile Arg Ala Glu Leu Lys Glu Ile
                  85                  90                  95

 aag aca caa aaa acc att caa gaa atc aac aag tcc agg agt tgg ttt      336
 Lys Thr Gln Lys Thr Ile Gln Glu Ile Asn Lys Ser Arg Ser Trp Phe
             100                 105                 110

 ttt gaa aaa aat aat aag ata gaa agg act tcc ttg caa gaa ttt aac      384
 Phe Glu Lys Asn Asn Lys Ile Glu Arg Thr Ser Leu Gln Glu Phe Asn
         115                 120                 125

 ctg tcc aac ctt gta gaa tct atc aca tct gcc agg atc aca act gaa      432
 Leu Ser Asn Leu Val Glu Ser Ile Thr Ser Ala Arg Ile Thr Thr Glu
     130                 135                 140

 ggt gga ggc gtc ctc tct gag ttc ttg tac aat atg cag ggc cag agg      480
 Gly Gly Gly Val Leu Ser Glu Phe Leu Tyr Asn Met Gln Gly Gln Arg
 145                 150                 155                 160

 tct tgc att ggc tct gct ttg ctc tct gtt ctc ctg gcc atc ctc aga      528
 Ser Cys Ile Gly Ser Ala Leu Leu Ser Val Leu Leu Ala Ile Leu Arg
                 165                 170                 175

 ccc aga gcc aca gtc cct gaa gac att act aac caa cct ctc cca tac      576
 Pro Arg Ala Thr Val Pro Glu Asp Ile Thr Asn Gln Pro Leu Pro Tyr
             180                 185                 190

 tct ttg ctg agc caa gac acc atg cgg act tct caa ggt ggc ctt cca      624
 Ser Leu Leu Ser Gln Asp Thr Met Arg Thr Ser Gln Gly Gly Leu Pro
         195                 200                 205

 cta cca atc aga gtg ggt gca gat gat gga gtg gtc aaa tca gaa tct      672
 Leu Pro Ile Arg Val Gly Ala Asp Asp Gly Val Val Lys Ser Glu Ser
     210                 215                 220

 gga agc atc tgt tct gct tct ggc tgc atc tct taa                      708
 Gly Ser Ile Cys Ser Ala Ser Gly Cys Ile Ser 
 225                 230                 235





      <210> 609
      <211> 408
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (1)..(408)

      <400> 609
  atg cgg cag atg cat aca gtg gaa tat tat ttg gcc ttg aaa agg aag      48
  Met Arg Gln Met His Thr Val Glu Tyr Tyr Leu Ala Leu Lys Arg Lys
    1               5                  10                  15

 gaa att cag aca cat gct acc aca tgg atg aaa gtt gag ggc att agg       96
 Glu Ile Gln Thr His Ala Thr Thr Trp Met Lys Val Glu Gly Ile Arg
              20                  25                  30

 cta agt gaa ata agc cag aca cag aaa gac aaa tat gtc ctg gcc aaa      144
 Leu Ser Glu Ile Ser Gln Thr Gln Lys Asp Lys Tyr Val Leu Ala Lys
          35                  40                  45

 ggc agt ggc ttc tgt tgc tgc tcc cgt caa gaa gtg cct tcc tat cct      192
 Gly Ser Gly Phe Cys Cys Cys Ser Arg Gln Glu Val Pro Ser Tyr Pro
      50                  55                  60

 gcc cat ctg ctc aca ttt cta tca ctg cag ctc aca gac ttc ggt tgt      240
 Ala His Leu Leu Thr Phe Leu Ser Leu Gln Leu Thr Asp Phe Gly Cys
  65                  70                  75                  80

 ctt tca cac ccc aga aat gtg agt act ttg aga gca gca act gta atg      288
 Leu Ser His Pro Arg Asn Val Ser Thr Leu Arg Ala Ala Thr Val Met
                  85                  90                  95

 cag ccg ctg aca tac aat cgc ttg ctc aga aaa tac act gaa agt gaa      336
 Gln Pro Leu Thr Tyr Asn Arg Leu Leu Arg Lys Tyr Thr Glu Ser Glu
             100                 105                 110

 tta atg cgc agc tat gtt ctg cat ttt att tct atc tct gat aat att      384
 Leu Met Arg Ser Tyr Val Leu His Phe Ile Ser Ile Ser Asp Asn Ile
         115                 120                 125

 tct gac gat gaa atg tat gat taa                                      408
 Ser Asp Asp Glu Met Tyr Asp 
     130                 135





      <210> 610
      <211> 2226
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (1)..(2226)

      <400> 610
  atg gcg gcg ctg cgg ctc ctg gcg tca gtg ctc ggg cgc ggg gtc ccc      48
  Met Ala Ala Leu Arg Leu Leu Ala Ser Val Leu Gly Arg Gly Val Pro
    1               5                  10                  15

 gcc ggc ggc tca ggg ctc gcg ctg tcc cag ggc tgc gcc cgc tgc ttt       96
 Ala Gly Gly Ser Gly Leu Ala Leu Ser Gln Gly Cys Ala Arg Cys Phe
              20                  25                  30

 gcc acc agt ccc cgg ccc cgt gcc aag ttc tac gcg gac ccg gtg gag      144
 Ala Thr Ser Pro Arg Pro Arg Ala Lys Phe Tyr Ala Asp Pro Val Glu
          35                  40                  45

 atg gtg aag gac atc tct gac ggg gcg acc gtc atg atc ggg ggc ttc      192
 Met Val Lys Asp Ile Ser Asp Gly Ala Thr Val Met Ile Gly Gly Phe
      50                  55                  60

 ggg ctc tgc ggg atc ccc gag aac ctg atc gcc gcg ctg ctc agg acc      240
 Gly Leu Cys Gly Ile Pro Glu Asn Leu Ile Ala Ala Leu Leu Arg Thr
  65                  70                  75                  80

 cgc gtg aaa gac ctg cag gtg gtc agc agc aac gtg ggc gtg gag gac      288
 Arg Val Lys Asp Leu Gln Val Val Ser Ser Asn Val Gly Val Glu Asp
                  85                  90                  95

 ttc ggc ctg ggc ctc ctg ctg gcc gcc agg cag gtc cgt cgc atc gtc      336
 Phe Gly Leu Gly Leu Leu Leu Ala Ala Arg Gln Val Arg Arg Ile Val
             100                 105                 110

 tgt tcc tac gtg ggc gag aac acc ctg tgc gag agc cag tac ctg gca      384
 Cys Ser Tyr Val Gly Glu Asn Thr Leu Cys Glu Ser Gln Tyr Leu Ala
         115                 120                 125

 gga gag ctg gag ctg gag ctc acg ccc cag ggc acc ctg gcc gag cgc      432
 Gly Glu Leu Glu Leu Glu Leu Thr Pro Gln Gly Thr Leu Ala Glu Arg
     130                 135                 140

 atc cgc gcg ggg ggc gcc ggg gtg ccc gcc ttc tac acc ccc acg ggc      480
 Ile Arg Ala Gly Gly Ala Gly Val Pro Ala Phe Tyr Thr Pro Thr Gly
 145                 150                 155                 160

 tac ggg acc ctg gtc cag gaa ggg ggc gcc ccc atc cgc tac acc ccg      528
 Tyr Gly Thr Leu Val Gln Glu Gly Gly Ala Pro Ile Arg Tyr Thr Pro
                 165                 170                 175

 gac ggc cac ctg gcg ctc atg agc cag ccc cga gag gtg agg gag ttc      576
 Asp Gly His Leu Ala Leu Met Ser Gln Pro Arg Glu Val Arg Glu Phe
             180                 185                 190

 aac ggc gac cac ttc ctt ttg gag cgc gcc atc cgg gca gac ttc gcc      624
 Asn Gly Asp His Phe Leu Leu Glu Arg Ala Ile Arg Ala Asp Phe Ala
         195                 200                 205

 ctg gtg aaa ggg tgg aag gcc gac cgg gca gga aac gtg gtc ttc agg      672
 Leu Val Lys Gly Trp Lys Ala Asp Arg Ala Gly Asn Val Val Phe Arg
     210                 215                 220

 aga agc gcc cgc aat ttc aac gtg ccc atg tgc aaa gct gca gac gtc      720
 Arg Ser Ala Arg Asn Phe Asn Val Pro Met Cys Lys Ala Ala Asp Val
 225                 230                 235                 240

 acg gcg gtg gag ggg cag aaa tac gag aaa cga att gag cgc tta acg      768
 Thr Ala Val Glu Gly Gln Lys Tyr Glu Lys Arg Ile Glu Arg Leu Thr
                 245                 250                 255

 atc cgg aaa gag gaa gat gga gac gct gga aag gaa gag gac gcc agg      816
 Ile Arg Lys Glu Glu Asp Gly Asp Ala Gly Lys Glu Glu Asp Ala Arg
             260                 265                 270

 acg cgc atc atc aga cgc gca gct ctg gaa ttt gag gac ggc atg tac      864
 Thr Arg Ile Ile Arg Arg Ala Ala Leu Glu Phe Glu Asp Gly Met Tyr
         275                 280                 285

 gcc aat ctg ggc ata ggc atc ccc ctg ctg gcc agc aac ttc atc agt      912
 Ala Asn Leu Gly Ile Gly Ile Pro Leu Leu Ala Ser Asn Phe Ile Ser
     290                 295                 300

 ccc agc atg act gtc cat ctt cac agt gag aac ggg atc ctg ggc ctg      960
 Pro Ser Met Thr Val His Leu His Ser Glu Asn Gly Ile Leu Gly Leu
 305                 310                 315                 320

 ggc ccg ttt ccc acg gaa gat gag gtg gat gcc gac ctc atc aat gca     1008
 Gly Pro Phe Pro Thr Glu Asp Glu Val Asp Ala Asp Leu Ile Asn Ala
                 325                 330                 335

 ggc aag cag acg gtc acg gtg ctt ccc ggg ggc tgc ttc ttc gcc agc     1056
 Gly Lys Gln Thr Val Thr Val Leu Pro Gly Gly Cys Phe Phe Ala Ser
             340                 345                 350

 gac gac tcc ttc gcc atg atc cga ggg gga cac atc caa cta acc atg     1104
 Asp Asp Ser Phe Ala Met Ile Arg Gly Gly His Ile Gln Leu Thr Met
         355                 360                 365

 ctt gga gcc atg cag gtt tcc aaa tac ggc gac ctg gcg aac tgg atg     1152
 Leu Gly Ala Met Gln Val Ser Lys Tyr Gly Asp Leu Ala Asn Trp Met
     370                 375                 380

 atc cct ggc aag aag gtg aaa ggc atg ggc ggt gcc atg gac ttg gtg     1200
 Ile Pro Gly Lys Lys Val Lys Gly Met Gly Gly Ala Met Asp Leu Val
 385                 390                 395                 400

 tcc agt cag aag acc aga gtg gtg gtc acc atg cag cac tgc aca aag     1248
 Ser Ser Gln Lys Thr Arg Val Val Val Thr Met Gln His Cys Thr Lys
                 405                 410                 415

 gac aac acc ccc aag atc atg gag aaa tgc acc atg ccg ctg acc ggg     1296
 Asp Asn Thr Pro Lys Ile Met Glu Lys Cys Thr Met Pro Leu Thr Gly
             420                 425                 430

 aag cgg tgc gtg gac cgc atc atc acc gag aag gcc gtg ttt gac gtg     1344
 Lys Arg Cys Val Asp Arg Ile Ile Thr Glu Lys Ala Val Phe Asp Val
         435                 440                 445

 cac agg aag aaa agg ctg acg ctg agg gag ctc tgg gag ggc ctg acg     1392
 His Arg Lys Lys Arg Leu Thr Leu Arg Glu Leu Trp Glu Gly Leu Thr
     450                 455                 460

 gtg gac gac atc aaa aag agc acg ggg tgt gcc ttt gct gtg tcc ccg     1440
 Val Asp Asp Ile Lys Lys Ser Thr Gly Cys Ala Phe Ala Val Ser Pro
 465                 470                 475                 480

 aac ctc agg ccc atg cag cag gtg cca gct gga gcc agg gag tcc tgc     1488
 Asn Leu Arg Pro Met Gln Gln Val Pro Ala Gly Ala Arg Glu Ser Cys
                 485                 490                 495

 cta aga atg ggt ggg gag aca gtt aat gcc ctg ctc ttg ggc tgt gcc     1536
 Leu Arg Met Gly Gly Glu Thr Val Asn Ala Leu Leu Leu Gly Cys Ala
             500                 505                 510

 cag cag aac aag cac tcg ctc aac ctg gca gat gct acc acg agc tgt     1584
 Gln Gln Asn Lys His Ser Leu Asn Leu Ala Asp Ala Thr Thr Ser Cys
         515                 520                 525

 ctc ggt gat aag ttt gac att cac acc cca gaa acc tcc acg ctc ctg     1632
 Leu Gly Asp Lys Phe Asp Ile His Thr Pro Glu Thr Ser Thr Leu Leu
     530                 535                 540

 gac ctg ccc agg ccc cgg cag aga gac cgc tgc tgt gtc tgc tgc agg     1680
 Asp Leu Pro Arg Pro Arg Gln Arg Asp Arg Cys Cys Val Cys Cys Arg
 545                 550                 555                 560

 gcc gct gcc cgg cac agc gtg gat cct ggc ctg gcc ggc ctg ctg ggt     1728
 Ala Ala Ala Arg His Ser Val Asp Pro Gly Leu Ala Gly Leu Leu Gly
                 565                 570                 575

 caa cgg gcc cca cgc tcc caa cag cct ttc gtg gtc act ttc ttc agg     1776
 Gln Arg Ala Pro Arg Ser Gln Gln Pro Phe Val Val Thr Phe Phe Arg
             580                 585                 590

 gcc agt ccg agt ccc atc cgc acc cct cgg gca gtg agg cca ctg agg     1824
 Ala Ser Pro Ser Pro Ile Arg Thr Pro Arg Ala Val Arg Pro Leu Arg
         595                 600                 605

 agg agg caa ccg aag aaa agc aac gag ctg ccg cag gcc aac cga ctc     1872
 Arg Arg Gln Pro Lys Lys Ser Asn Glu Leu Pro Gln Ala Asn Arg Leu
     610                 615                 620

 cca ggg atc ttt gat gac gtc cgc ggc tcc cac ggc cgg cag gtc tgc     1920
 Pro Gly Ile Phe Asp Asp Val Arg Gly Ser His Gly Arg Gln Val Cys
 625                 630                 635                 640

 cgt cgg cac gag ctc tac gtc agc ttc cag gac ctt ggc tgg ctg gac     1968
 Arg Arg His Glu Leu Tyr Val Ser Phe Gln Asp Leu Gly Trp Leu Asp
                 645                 650                 655

 tgg gtc atc gcc ccc caa ggc tac tca gcc tat tac tgt gag ggg gag     2016
 Trp Val Ile Ala Pro Gln Gly Tyr Ser Ala Tyr Tyr Cys Glu Gly Glu
             660                 665                 670

 tgc tcc ttc ccg ctg gac tcc tgc atg aac gcc acc aac cac gcc atc     2064
 Cys Ser Phe Pro Leu Asp Ser Cys Met Asn Ala Thr Asn His Ala Ile
         675                 680                 685

 ctg cag tcc ctg gtg cac ctg atg aag cca aac gca gtc ccc aag gcg     2112
 Leu Gln Ser Leu Val His Leu Met Lys Pro Asn Ala Val Pro Lys Ala
     690                 695                 700

 tgc tgt gca ccc acc aag ctg agc gcc acc tct gtg ctc tac tat gac     2160
 Cys Cys Ala Pro Thr Lys Leu Ser Ala Thr Ser Val Leu Tyr Tyr Asp
 705                 710                 715                 720

 agc agc aac aac gtc atc ctg cgc aag cac cgc aac atg gtg gtc aag     2208
 Ser Ser Asn Asn Val Ile Leu Arg Lys His Arg Asn Met Val Val Lys
                 725                 730                 735

 gcc tgc ggc tgc cac tga                                             2226
 Ala Cys Gly Cys His 
             740





      <210> 611
      <211> 768
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (1)..(768)

      <400> 611
  atg ctg tgc cgg ctc ggc ggt cgg tgg ctg cgg ccg ctc cct gcc ctg      48
  Met Leu Cys Arg Leu Gly Gly Arg Trp Leu Arg Pro Leu Pro Ala Leu
    1               5                  10                  15

 cag ctt tgg gct agg gac ctg ccg ctt gcg ccg gtt cct acg agc ggc       96
 Gln Leu Trp Ala Arg Asp Leu Pro Leu Ala Pro Val Pro Thr Ser Gly
              20                  25                  30

 gcc aag cgc ccc act ctc cca gtg tgg gca gtg gca cca gtc tct gca      144
 Ala Lys Arg Pro Thr Leu Pro Val Trp Ala Val Ala Pro Val Ser Ala
          35                  40                  45

 gta cat gcg aac ggc tgg tac gag gcc ctg gcc gcg tct tcg ccg gtg      192
 Val His Ala Asn Gly Trp Tyr Glu Ala Leu Ala Ala Ser Ser Pro Val
      50                  55                  60

 cgg gtt gcg gag gaa gta ctg ctc ggc gtg cac gcc gcc acg ggc ctg      240
 Arg Val Ala Glu Glu Val Leu Leu Gly Val His Ala Ala Thr Gly Leu
  65                  70                  75                  80

 ccc tgg tgg ggc agc att ctg ctc tcc acc gtg gcc tta cgg ggt gct      288
 Pro Trp Trp Gly Ser Ile Leu Leu Ser Thr Val Ala Leu Arg Gly Ala
                  85                  90                  95

 gtc acg ctg cct ttg gca gcc tac cag cac tac atc ctg gcc aag gtt      336
 Val Thr Leu Pro Leu Ala Ala Tyr Gln His Tyr Ile Leu Ala Lys Val
             100                 105                 110

 gtg agc atg ggg aaa aaa aac cgg aaa caa aac agg aac gga atc agc      384
 Val Ser Met Gly Lys Lys Asn Arg Lys Gln Asn Arg Asn Gly Ile Ser
         115                 120                 125

 agc aac att aag gca gtg gaa aat ttg cag cca gaa ata aaa act att      432
 Ser Asn Ile Lys Ala Val Glu Asn Leu Gln Pro Glu Ile Lys Thr Ile
     130                 135                 140

 gcc agg cat ctt aac caa gaa gtt gca gtt cgt gca aat cag ttg ggg      480
 Ala Arg His Leu Asn Gln Glu Val Ala Val Arg Ala Asn Gln Leu Gly
 145                 150                 155                 160

 tgg tcc aaa aga gat gcc aga tta gca gca tta gat tct cat agc acg      528
 Trp Ser Lys Arg Asp Ala Arg Leu Ala Ala Leu Asp Ser His Ser Thr
                 165                 170                 175

 aac cct att gtg aac tgc aca gaa gaa ggc aaa gaa aat gca ttc ctt      576
 Asn Pro Ile Val Asn Cys Thr Glu Glu Gly Lys Glu Asn Ala Phe Leu
             180                 185                 190

 act aca ctg aga aac tgg ctg ttg gga aac att tgg aag ata gat gac      624
 Thr Thr Leu Arg Asn Trp Leu Leu Gly Asn Ile Trp Lys Ile Asp Asp
         195                 200                 205

 tgt atg ggg aaa att agg tgt agg gag gct aag ttt gcc atc ata agt      672
 Cys Met Gly Lys Ile Arg Cys Arg Glu Ala Lys Phe Ala Ile Ile Ser
     210                 215                 220

 gcc aca ctt cca gca ttc tac ctt cag tat gta agc agt tgg aca gga      720
 Ala Thr Leu Pro Ala Phe Tyr Leu Gln Tyr Val Ser Ser Trp Thr Gly
 225                 230                 235                 240

 ctt ttg gtg ggg aaa aag tta tgt tcc att gtc gaa gaa ggg aga taa      768
 Leu Leu Val Gly Lys Lys Leu Cys Ser Ile Val Glu Glu Gly Arg 
                 245                 250                 255





      <210> 612
      <211> 2586
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (1)..(2586)

      <400> 612
  atg agg ctg ctg cgg cgc tgg gcg ttc gcg gct ctg ctg ctg tcg ctg      48
  Met Arg Leu Leu Arg Arg Trp Ala Phe Ala Ala Leu Leu Leu Ser Leu
    1               5                  10                  15

 ctc ccc acg ccc ggt ctt ggg acc caa ggt cct gct gga gct ctg cga       96
 Leu Pro Thr Pro Gly Leu Gly Thr Gln Gly Pro Ala Gly Ala Leu Arg
              20                  25                  30

 tgg ggg ggc tta ccc cag ctg gga ggc cca gga gcc cct gag gtc acg      144
 Trp Gly Gly Leu Pro Gln Leu Gly Gly Pro Gly Ala Pro Glu Val Thr
          35                  40                  45

 gaa ccc agc cgt ctg gtt agg gag agc tcc ggg gga gag gtc cga aag      192
 Glu Pro Ser Arg Leu Val Arg Glu Ser Ser Gly Gly Glu Val Arg Lys
      50                  55                  60

 cag cag ctg gac aca agg gtc cgc cag gag cca cca ggg ggc ccg cca      240
 Gln Gln Leu Asp Thr Arg Val Arg Gln Glu Pro Pro Gly Gly Pro Pro
  65                  70                  75                  80

 cct ggc cca caa ggt ggt ggt gtc tcc ttg cgg gag ggg att cca gaa      288
 Pro Gly Pro Gln Gly Gly Gly Val Ser Leu Arg Glu Gly Ile Pro Glu
                  85                  90                  95

 aga tgt cct cag cct gtc cat ctg gcc cag gtg agt ttc gtc atc cca      336
 Arg Cys Pro Gln Pro Val His Leu Ala Gln Val Ser Phe Val Ile Pro
             100                 105                 110

 gcc ttc aac tca aac ttc acc ctg gac ctg gag ctg aac cac cac ctc      384
 Ala Phe Asn Ser Asn Phe Thr Leu Asp Leu Glu Leu Asn His His Leu
         115                 120                 125

 ctc tcc tcg caa tac gtg gag cgc cac ttc agc cgg gag ggg aca acc      432
 Leu Ser Ser Gln Tyr Val Glu Arg His Phe Ser Arg Glu Gly Thr Thr
     130                 135                 140

 cag cac agc acc ggg gct gga gac cac tgc tac tac cag ggg aag ctc      480
 Gln His Ser Thr Gly Ala Gly Asp His Cys Tyr Tyr Gln Gly Lys Leu
 145                 150                 155                 160

 cgg ggg aac ccg cac tcc ttc gcc gcc ctc tcc acc tgc cag ggg ctg      528
 Arg Gly Asn Pro His Ser Phe Ala Ala Leu Ser Thr Cys Gln Gly Leu
                 165                 170                 175

 cat ggg gtc ttc tct gat ggg aac ttg act tac atc gtg gag ccc caa      576
 His Gly Val Phe Ser Asp Gly Asn Leu Thr Tyr Ile Val Glu Pro Gln
             180                 185                 190

 gag gtg gct gga cct tgg gga gcc cct cag atc ccc tcg gat gca ggg      624
 Glu Val Ala Gly Pro Trp Gly Ala Pro Gln Ile Pro Ser Asp Ala Gly
         195                 200                 205

 aac cag gtc cgc cgg ggc cac cct aca gtg cac agt gaa acc aag tat      672
 Asn Gln Val Arg Arg Gly His Pro Thr Val His Ser Glu Thr Lys Tyr
     210                 215                 220

 gtg gag cta att gtg atc aac gac cac cag ctg ttc gag cag atg cga      720
 Val Glu Leu Ile Val Ile Asn Asp His Gln Leu Phe Glu Gln Met Arg
 225                 230                 235                 240

 cag tcg gtg gtc ctc acc agc aac ttt gcc aag tcc gtg gtg aac ctg      768
 Gln Ser Val Val Leu Thr Ser Asn Phe Ala Lys Ser Val Val Asn Leu
                 245                 250                 255

 gcc gat gtg ata tac aag gag cag ctc aac act cgc atc gtc ctg gtt      816
 Ala Asp Val Ile Tyr Lys Glu Gln Leu Asn Thr Arg Ile Val Leu Val
             260                 265                 270

 gcc atg gaa aca tgg gca gat ggg gac aag atc cag gtg cag gat gac      864
 Ala Met Glu Thr Trp Ala Asp Gly Asp Lys Ile Gln Val Gln Asp Asp
         275                 280                 285

 ctc ctg gag acc ctg gcc cgg ctc atg gtc tac cga cgg gag ggt ctg      912
 Leu Leu Glu Thr Leu Ala Arg Leu Met Val Tyr Arg Arg Glu Gly Leu
     290                 295                 300

 cct gag ccc agt gat gcc acc cac ctc ttc tcg ggc agg acc ttc cag      960
 Pro Glu Pro Ser Asp Ala Thr His Leu Phe Ser Gly Arg Thr Phe Gln
 305                 310                 315                 320

 agc acg agc agc ggg gca gcc tac gtg ggg ggc ata tgc tcc ctg tcc     1008
 Ser Thr Ser Ser Gly Ala Ala Tyr Val Gly Gly Ile Cys Ser Leu Ser
                 325                 330                 335

 cac ggc ggg ggt gtg aac gag tac ggc aac atg ggg gcg atg gcc gtg     1056
 His Gly Gly Gly Val Asn Glu Tyr Gly Asn Met Gly Ala Met Ala Val
             340                 345                 350

 acc ctt gcc cag acg ctg gga cag aac ctg ggc atg atg tgg aac aaa     1104
 Thr Leu Ala Gln Thr Leu Gly Gln Asn Leu Gly Met Met Trp Asn Lys
         355                 360                 365

 cac cgg agc tcg gca ggg gac tgc aag tgt cca gac atc tgg ctg ggc     1152
 His Arg Ser Ser Ala Gly Asp Cys Lys Cys Pro Asp Ile Trp Leu Gly
     370                 375                 380

 tgc atc atg gag gac act ggg ttc tac ctg ccc cgc aag ttc tcg cgc     1200
 Cys Ile Met Glu Asp Thr Gly Phe Tyr Leu Pro Arg Lys Phe Ser Arg
 385                 390                 395                 400

 tgt agc atc gac gag tac aac cag ttt ctg cag gag ggt ggt ggc agc     1248
 Cys Ser Ile Asp Glu Tyr Asn Gln Phe Leu Gln Glu Gly Gly Gly Ser
                 405                 410                 415

 tgc ctc ttc aac aag ccc ctc aag ctc ctg gac ccc cca gag tgc ggg     1296
 Cys Leu Phe Asn Lys Pro Leu Lys Leu Leu Asp Pro Pro Glu Cys Gly
             420                 425                 430

 aac ggc ttc gtg gag gca ggg gag gag tgc gac tgc ggc tcg gtg cag     1344
 Asn Gly Phe Val Glu Ala Gly Glu Glu Cys Asp Cys Gly Ser Val Gln
         435                 440                 445

 gag tgc agc cgc gca ggt ggc aac tgc tgc aag aaa tgc acc ctg act     1392
 Glu Cys Ser Arg Ala Gly Gly Asn Cys Cys Lys Lys Cys Thr Leu Thr
     450                 455                 460

 cac gac gcc atg tgc agc gac ggg ctc tgc tgt cgc cgc tgc aag tac     1440
 His Asp Ala Met Cys Ser Asp Gly Leu Cys Cys Arg Arg Cys Lys Tyr
 465                 470                 475                 480

 gaa cca cgg ggt gtg tcc tgc cga gag gcc gtg aac gag tgc gac atc     1488
 Glu Pro Arg Gly Val Ser Cys Arg Glu Ala Val Asn Glu Cys Asp Ile
                 485                 490                 495

 gcg gag acc tgc acc ggg gac tct agc cag tgc ccg cct aac ctg cac     1536
 Ala Glu Thr Cys Thr Gly Asp Ser Ser Gln Cys Pro Pro Asn Leu His
             500                 505                 510

 aag ctg gac ggt tac tac tgt gac cat gag cag ggc cgc tgc tac gga     1584
 Lys Leu Asp Gly Tyr Tyr Cys Asp His Glu Gln Gly Arg Cys Tyr Gly
         515                 520                 525

 ggt cgc tgc aaa acc cgg gac cgg cag tgc cag gtt ctt tgg ggc cat     1632
 Gly Arg Cys Lys Thr Arg Asp Arg Gln Cys Gln Val Leu Trp Gly His
     530                 535                 540

 gcg gct gct gat cgc ttc tgc tac gag aag ctg aat gtg gag ggg acg     1680
 Ala Ala Ala Asp Arg Phe Cys Tyr Glu Lys Leu Asn Val Glu Gly Thr
 545                 550                 555                 560

 gag cgt ggg agc tgt ggg cgc aag gga tct ggc tgg gtc cag tgc agt     1728
 Glu Arg Gly Ser Cys Gly Arg Lys Gly Ser Gly Trp Val Gln Cys Ser
                 565                 570                 575

 aag cag gac gtg ctg tgt ggc ttc ctc ctc tgt gtc aac atc tct gga     1776
 Lys Gln Asp Val Leu Cys Gly Phe Leu Leu Cys Val Asn Ile Ser Gly
             580                 585                 590

 gct cct cgg cta ggg gac ctg gtg gga gac atc agt agt gtc acc ttc     1824
 Ala Pro Arg Leu Gly Asp Leu Val Gly Asp Ile Ser Ser Val Thr Phe
         595                 600                 605

 tac cac cag ggc aag gag ctg gac tgc agg gga ggc cac gtg cag ctg     1872
 Tyr His Gln Gly Lys Glu Leu Asp Cys Arg Gly Gly His Val Gln Leu
     610                 615                 620

 gcg gac ggc tct gac ctg agc tat gtg gag gat ggc aca gcc tgc ggg     1920
 Ala Asp Gly Ser Asp Leu Ser Tyr Val Glu Asp Gly Thr Ala Cys Gly
 625                 630                 635                 640

 cct aac atg ttg tgc ctg gac cat cgc tgc ctg cca gct tct gcc ttc     1968
 Pro Asn Met Leu Cys Leu Asp His Arg Cys Leu Pro Ala Ser Ala Phe
                 645                 650                 655

 aac ttc agc acc tgc ccc ggc agt ggg gag cgc cgg att tgc tcc cac     2016
 Asn Phe Ser Thr Cys Pro Gly Ser Gly Glu Arg Arg Ile Cys Ser His
             660                 665                 670

 cac ggg gtc tgc agc aat gaa ggg aag tgc atc tgt cag cca gac tgg     2064
 His Gly Val Cys Ser Asn Glu Gly Lys Cys Ile Cys Gln Pro Asp Trp
         675                 680                 685

 aca ggc aaa gac tgc agt atc cat aac ccc ctg ccc acg tcc cca ccc     2112
 Thr Gly Lys Asp Cys Ser Ile His Asn Pro Leu Pro Thr Ser Pro Pro
     690                 695                 700

 acg ggg gag acg gag aga tat aaa ggt ccc agc ggc acc aac atc atc     2160
 Thr Gly Glu Thr Glu Arg Tyr Lys Gly Pro Ser Gly Thr Asn Ile Ile
 705                 710                 715                 720

 att ggc tcc att gct ggg gct gtc ctg gtt gca gcc atc gtc ctg ggc     2208
 Ile Gly Ser Ile Ala Gly Ala Val Leu Val Ala Ala Ile Val Leu Gly
                 725                 730                 735

 ggc acg ggc tgg gga ttt aaa aac att cgc cga gga aga gtg ctt ggg     2256
 Gly Thr Gly Trp Gly Phe Lys Asn Ile Arg Arg Gly Arg Val Leu Gly
             740                 745                 750

 cct gga gaa gat cag cag gag aga gaa gca gct cca gcc caa ggc ttc     2304
 Pro Gly Glu Asp Gln Gln Glu Arg Glu Ala Ala Pro Ala Gln Gly Phe
         755                 760                 765

 atg ctg agg aag att ctt gaa gac ttt cag ctg agc cca gaa acc cag     2352
 Met Leu Arg Lys Ile Leu Glu Asp Phe Gln Leu Ser Pro Glu Thr Gln
     770                 775                 780

 tgc ctg cgg cct agg ctc ttc agg cct ttg gtg ttg aaa gca aag aat     2400
 Cys Leu Arg Pro Arg Leu Phe Arg Pro Leu Val Leu Lys Ala Lys Asn
 785                 790                 795                 800

 ccc agg cac ttc ttc cat gtg gag ctg gat ccc agc cgc ccc cga aag     2448
 Pro Arg His Phe Phe His Val Glu Leu Asp Pro Ser Arg Pro Arg Lys
                 805                 810                 815

 cac cat gtc gcc gtc atc tca gcg gcc cct gcg agg aac acg ttc tac     2496
 His His Val Ala Val Ile Ser Ala Ala Pro Ala Arg Asn Thr Phe Tyr
             820                 825                 830

 gac tcc att gtc ggt ggc ctg cca gcg cac cgg tgc ctg tca gtg ttc     2544
 Asp Ser Ile Val Gly Gly Leu Pro Ala His Arg Cys Leu Ser Val Phe
         835                 840                 845

 ctc cgg aca tcc agc cac ctg cat ctg cct act agg gtc tag             2586
 Leu Arg Thr Ser Ser His Leu His Leu Pro Thr Arg Val 
     850                 855                 860





      <210> 613
      <211> 1917
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (178)..(1917)

      <400> 613
 gccctggaga aagcagagag taaggcacaa aatccctggg agagccacag ggaggaggag     60

 aggcagcagg tggcagaaga gtctgcagag aagtggtgca gcccttccgc ctccccgggg    120

 ctgtcctgca gcgggaacat ccagggctac cccagctcag aacagagccg gcttgcc       177                                                                 
 atg ggg gct tat gtt ctg gaa ggt gtc ctc ggg gtg gtg ctg ggc cat      225
 Met Gly Ala Tyr Val Leu Glu Gly Val Leu Gly Val Val Leu Gly His
   1               5                  10                  15

 gct ggc ttc acc ctc cca aga gct ggc agc cac cag gtg ggt gct gcc      273
 Ala Gly Phe Thr Leu Pro Arg Ala Gly Ser His Gln Val Gly Ala Ala
              20                  25                  30

 cag ttt ctg gtc cac atc ggt ggt cgc ccc agc cag cct gtg gcc tcg      321
 Gln Phe Leu Val His Ile Gly Gly Arg Pro Ser Gln Pro Val Ala Ser
          35                  40                  45

 gac ttg gac gtg tgt gga agg cag cag cac acg ctg gtc acg tgt gca      369
 Asp Leu Asp Val Cys Gly Arg Gln Gln His Thr Leu Val Thr Cys Ala
      50                  55                  60

 gcg ggg ggc ttc gcc acc ttc tcc tcc tgc ttc ccc ggc ctc tgc gag      417
 Ala Gly Gly Phe Ala Thr Phe Ser Ser Cys Phe Pro Gly Leu Cys Glu
  65                  70                  75                  80

 ggc aag cct gct gcc ctg cta ccc atg agc ctc tcc cag ccc tgc ctg      465
 Gly Lys Pro Ala Ala Leu Leu Pro Met Ser Leu Ser Gln Pro Cys Leu
                  85                  90                  95

 cct gtg ccc agc gtg ggc ctg acc cgc atc ctg cct cac ctc tac ctg      513
 Pro Val Pro Ser Val Gly Leu Thr Arg Ile Leu Pro His Leu Tyr Leu
             100                 105                 110

 ggc tcg cag aag gac gtc cta aac aag gat ctg atg acg caa aat gga      561
 Gly Ser Gln Lys Asp Val Leu Asn Lys Asp Leu Met Thr Gln Asn Gly
         115                 120                 125

 ata agc tac gtc ctc aac gcc agc aac tcc tgc ccc aag cct gac ttc      609
 Ile Ser Tyr Val Leu Asn Ala Ser Asn Ser Cys Pro Lys Pro Asp Phe
     130                 135                 140

 atc tgc gag agc cgc ttc atg cgg gtc ccc atc aac gac aac tac tgt      657
 Ile Cys Glu Ser Arg Phe Met Arg Val Pro Ile Asn Asp Asn Tyr Cys
 145                 150                 155                 160

 gaa aaa ctg ctg ccc tgg ctg gac aag tcc atc gag ttc atc gat aaa      705
 Glu Lys Leu Leu Pro Trp Leu Asp Lys Ser Ile Glu Phe Ile Asp Lys
                 165                 170                 175

 gcc aag ctc tcc agc tgc caa gtc atc gtc cac tgt ctg gct ggc atc      753
 Ala Lys Leu Ser Ser Cys Gln Val Ile Val His Cys Leu Ala Gly Ile
             180                 185                 190

 tcc cgc tct gcc acc atc gcc atc gcc tac atc atg aag acc atg ggc      801
 Ser Arg Ser Ala Thr Ile Ala Ile Ala Tyr Ile Met Lys Thr Met Gly
         195                 200                 205

 atg tcc tcc gac gac gcc tac agg ttc gtg aag gac agg cgc ccg tcc      849
 Met Ser Ser Asp Asp Ala Tyr Arg Phe Val Lys Asp Arg Arg Pro Ser
     210                 215                 220

 atc tcg ccc aac ttc aac ttc ctg ggc cag ctg ctg gag tac gag cgc      897
 Ile Ser Pro Asn Phe Asn Phe Leu Gly Gln Leu Leu Glu Tyr Glu Arg
 225                 230                 235                 240

 agc ctg aag ctg ctg gcc gcc ctg cag ggc gac ccg ggc acc ccc tca      945
 Ser Leu Lys Leu Leu Ala Ala Leu Gln Gly Asp Pro Gly Thr Pro Ser
                 245                 250                 255

 ggg acg ccg gag cct ccg ccc agt cct gcc gcc ggg gcc ccg ctg cca      993
 Gly Thr Pro Glu Pro Pro Pro Ser Pro Ala Ala Gly Ala Pro Leu Pro
             260                 265                 270

 cgg ctg cca cca cct acc tca gag agc gct gcc aca ggg aat gcg gct     1041
 Arg Leu Pro Pro Pro Thr Ser Glu Ser Ala Ala Thr Gly Asn Ala Ala
         275                 280                 285

 gcc agg gag ggc ggc ctg agc gcg ggc ggg gag ccc ccc gcg ccc ccc     1089
 Ala Arg Glu Gly Gly Leu Ser Ala Gly Gly Glu Pro Pro Ala Pro Pro
     290                 295                 300

 acg ccc ccg gcg acc agc gca ctg cag cag ggc ctg cgc ggc ctg cac     1137
 Thr Pro Pro Ala Thr Ser Ala Leu Gln Gln Gly Leu Arg Gly Leu His
 305                 310                 315                 320

 ctc tcc tcg gac cgc ctg cag gac act aac cgc ctc aag cgc tcc ttc     1185
 Leu Ser Ser Asp Arg Leu Gln Asp Thr Asn Arg Leu Lys Arg Ser Phe
                 325                 330                 335

 tcc ctg gac atc aag tct gcc tac gcc cct agc atg cgg ccc gac ggc     1233
 Ser Leu Asp Ile Lys Ser Ala Tyr Ala Pro Ser Met Arg Pro Asp Gly
             340                 345                 350

 ccc ggg ccc ccc gac ccc ggc gag gcc ccg aag ctc tgc aag ctg gac     1281
 Pro Gly Pro Pro Asp Pro Gly Glu Ala Pro Lys Leu Cys Lys Leu Asp
         355                 360                 365

 agc ccg tcg ggg gcc gcg ctg ggc ctg tcc tcg ccc atc ccg gac agc     1329
 Ser Pro Ser Gly Ala Ala Leu Gly Leu Ser Ser Pro Ile Pro Asp Ser
     370                 375                 380

 ccg gac gcc gcg cct gat gcg cgc cca cgg ccc cgc cgg cgg ccc cgg     1377
 Pro Asp Ala Ala Pro Asp Ala Arg Pro Arg Pro Arg Arg Arg Pro Arg
 385                 390                 395                 400

 ccc ccc gcc ggc tcc ccc gcg cgc tcc ccc gcg cac agc ctc ggc ctg     1425
 Pro Pro Ala Gly Ser Pro Ala Arg Ser Pro Ala His Ser Leu Gly Leu
                 405                 410                 415

 aac ttc ggc gat gcg gcc cgg cag act ccg cgg cac ggc ctc tcg gcc     1473
 Asn Phe Gly Asp Ala Ala Arg Gln Thr Pro Arg His Gly Leu Ser Ala
             420                 425                 430

 ctg tcg gcg ccc ggg ctg ccc ggc cct ggc cag ccg gcc ggc ccc ggg     1521
 Leu Ser Ala Pro Gly Leu Pro Gly Pro Gly Gln Pro Ala Gly Pro Gly
         435                 440                 445

 gcc tgg gca ccg ccg ctc gac tcc cca ggc acg ccg tcg ccc gac ggg     1569
 Ala Trp Ala Pro Pro Leu Asp Ser Pro Gly Thr Pro Ser Pro Asp Gly
     450                 455                 460

 ccc tgg tgc ttc agc ccc gag ggc gca cag ggg gcg ggc ggg gtg ctg     1617
 Pro Trp Cys Phe Ser Pro Glu Gly Ala Gln Gly Ala Gly Gly Val Leu
 465                 470                 475                 480

 ttt gcg ccc ttc ggc cgg gcg ggc gcc ccg gga cca ggc ggc ggc agc     1665
 Phe Ala Pro Phe Gly Arg Ala Gly Ala Pro Gly Pro Gly Gly Gly Ser
                 485                 490                 495

 gac ctg cgg cgg cgg gag gca gcg agg gct gag ccc cgg gac gcg cgg     1713
 Asp Leu Arg Arg Arg Glu Ala Ala Arg Ala Glu Pro Arg Asp Ala Arg
             500                 505                 510

 acc ggc tgg ccc gag gag ccg gcc ccg gag acg cag ttc aag cgc cgc     1761
 Thr Gly Trp Pro Glu Glu Pro Ala Pro Glu Thr Gln Phe Lys Arg Arg
         515                 520                 525

 agc tgc cag atg gag ttc gag gag ggc atg gga gtt cag gcg cca gcc     1809
 Ser Cys Gln Met Glu Phe Glu Glu Gly Met Gly Val Gln Ala Pro Ala
     530                 535                 540

 aag ccc ctg tgc tgc tgg gat agg cct gct tca ctt agg gag cac tgc     1857
 Lys Pro Leu Cys Cys Trp Asp Arg Pro Ala Ser Leu Arg Glu His Cys
 545                 550                 555                 560

 ctc aag aca ggt ggc atg cca gcc ccc aaa cac aag tgg ctt ttg ggc     1905
 Leu Lys Thr Gly Gly Met Pro Ala Pro Lys His Lys Trp Leu Leu Gly
                 565                 570                 575

 cca ggc cgt tga                                                     1917
 Pro Gly Arg 






      <210> 614
      <211> 333
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (1)..(333)

      <400> 614
  atg att gtg ggg att ttt gcc ctg tgc tgg tta cct gtg cat gct gtt      48
  Met Ile Val Gly Ile Phe Ala Leu Cys Trp Leu Pro Val His Ala Val
    1               5                  10                  15

 aac tgt gtc act ctt ttc cag cca gct cag ggt aaa aat aag ccc aag       96
 Asn Cys Val Thr Leu Phe Gln Pro Ala Gln Gly Lys Asn Lys Pro Lys
              20                  25                  30

 tgg gca atg aat atg gcc att ctt ctg tca cat gcc aat tca gtt gtc      144
 Trp Ala Met Asn Met Ala Ile Leu Leu Ser His Ala Asn Ser Val Val
          35                  40                  45

 aat ccc att gtc tat gct tac cgg aac cga gac ttc cgc tac act ttt      192
 Asn Pro Ile Val Tyr Ala Tyr Arg Asn Arg Asp Phe Arg Tyr Thr Phe
      50                  55                  60

 cac aaa att atc tcc agg tat ctt ctc tgc caa gca gat gtc aag agt      240
 His Lys Ile Ile Ser Arg Tyr Leu Leu Cys Gln Ala Asp Val Lys Ser
  65                  70                  75                  80

 ggg aat gct tca ctc atg atc ttt tac ata aaa att cag gaa att gat      288
 Gly Asn Ala Ser Leu Met Ile Phe Tyr Ile Lys Ile Gln Glu Ile Asp
                  85                  90                  95

 gca gtt cta aaa atg aca ttg cat ttt gag agg cta aac ccc taa          333
 Ala Val Leu Lys Met Thr Leu His Phe Glu Arg Leu Asn Pro 
             100                 105                 110





      <210> 615
      <211> 546
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (70)..(546)

      <400> 615
 ctgctggaag tgttggtgaa tgactcacca aagttgcttt tcaagagtta ccctctgcta     60

 aagagagcc    atg ttg acc gtg gtc acg tcc act ttc tgg ggg ctg cct     108
              Met Leu Thr Val Val Thr Ser Thr Phe Trp Gly Leu Pro
                1               5                  10

 ata tcc act ttc tgg ggg ccg tgg gat gga ggg aga gtc ttg gtt cag      156
 Ile Ser Thr Phe Trp Gly Pro Trp Asp Gly Gly Arg Val Leu Val Gln
      15                  20                  25

 ggt ggc gga gtc ttt agt gat agg tct ggt agt ggc aaa tgg gca gag      204
 Gly Gly Gly Val Phe Ser Asp Arg Ser Gly Ser Gly Lys Trp Ala Glu
  30                  35                  40                  45

 aag gaa ctg gtg ttc atg tca gca ggt att gat gaa aga gga ggt aca      252
 Lys Glu Leu Val Phe Met Ser Ala Gly Ile Asp Glu Arg Gly Gly Thr
                  50                  55                  60

 aca tct tgg gga aca agt ggt caa cca agt cct tcc tat gat tca tct      300
 Thr Ser Trp Gly Thr Ser Gly Gln Pro Ser Pro Ser Tyr Asp Ser Ser
              65                  70                  75

 aga ggt ttt aca gac agc cct cat tac agt gat cac ttg aat gac agt      348
 Arg Gly Phe Thr Asp Ser Pro His Tyr Ser Asp His Leu Asn Asp Ser
          80                  85                  90

 cga tta gga gcc cat gaa ggc ttg tcc cca aca cct ttc atg aac tca      396
 Arg Leu Gly Ala His Glu Gly Leu Ser Pro Thr Pro Phe Met Asn Ser
      95                 100                 105

 aat ctg atg gta ttt gaa gca ttt gga act gtt gat aac caa tca tcg      444
 Asn Leu Met Val Phe Glu Ala Phe Gly Thr Val Asp Asn Gln Ser Ser
 110                 115                 120                 125

 caa cag gta aca gtt gag agt ggt gct gtg cat gat gaa tgt tca gaa      492
 Gln Gln Val Thr Val Glu Ser Gly Ala Val His Asp Glu Cys Ser Glu
                 130                 135                 140

 aca gct aaa act aat agg aaa gca gta aca ttt cct gtt gct gtc aac      540
 Thr Ala Lys Thr Asn Arg Lys Ala Val Thr Phe Pro Val Ala Val Asn
             145                 150                 155

 ata taa                                                              546
 Ile 






      <210> 616
      <211> 1323
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (1)..(1323)

      <400> 616
  atg cta gca gcc ctc ggt tgc tct cgg cgc ctc ctt ggc ctc ggc ctc      48
  Met Leu Ala Ala Leu Gly Cys Ser Arg Arg Leu Leu Gly Leu Gly Leu
    1               5                  10                  15

 cgc tct ggc ctc gct cga gga gcc ctt cag ccc acc tct gcg ctg tgg       96
 Arg Ser Gly Leu Ala Arg Gly Ala Leu Gln Pro Thr Ser Ala Leu Trp
              20                  25                  30

 ggg ctc ctc tct ggg gct gac caa ggc cgg agc cgg ctc cct ctg cta      144
 Gly Leu Leu Ser Gly Ala Asp Gln Gly Arg Ser Arg Leu Pro Leu Leu
          35                  40                  45

 gca ggg aga tat atg gtg gaa cta gca gct ggg aaa cca cat cat acc      192
 Ala Gly Arg Tyr Met Val Glu Leu Ala Ala Gly Lys Pro His His Thr
      50                  55                  60

 aag ttc aag act cga ggt tcc ttg gct aac cct gca ttc cca atc tct      240
 Lys Phe Lys Thr Arg Gly Ser Leu Ala Asn Pro Ala Phe Pro Ile Ser
  65                  70                  75                  80

 gag gct gat ctc tgg cac aat tcc tca aga aga ggg tgt ttt ggg ttt      288
 Glu Ala Asp Leu Trp His Asn Ser Ser Arg Arg Gly Cys Phe Gly Phe
                  85                  90                  95

 gct gtg gag ccc ggg ctc ttg cag act cct ccc cac cag tgt cca cgg      336
 Ala Val Glu Pro Gly Leu Leu Gln Thr Pro Pro His Gln Cys Pro Arg
             100                 105                 110

 aac act att tgc aat aaa ggt gaa tgg tta aaa ata aat gaa tat aat      384
 Asn Thr Ile Cys Asn Lys Gly Glu Trp Leu Lys Ile Asn Glu Tyr Asn
         115                 120                 125

 aaa ata gtg gaa tgc aat ata tcc agg cat ggc aca ggg cct cgc ctc      432
 Lys Ile Val Glu Cys Asn Ile Ser Arg His Gly Thr Gly Pro Arg Leu
     130                 135                 140

 act atg gca gca gca cgg cac agc atg ctc gac ttc acg ctc ggc gcc      480
 Thr Met Ala Ala Ala Arg His Ser Met Leu Asp Phe Thr Leu Gly Ala
 145                 150                 155                 160

 aaa gct gat ggt gag act gtt cta aaa ggc ctc cag tcc att ttc cag      528
 Lys Ala Asp Gly Glu Thr Val Leu Lys Gly Leu Gln Ser Ile Phe Gln
                 165                 170                 175

 gag cag ggg atg gca gag tcg gtg cac acc tgg cag gac cat ggc tat      576
 Glu Gln Gly Met Ala Glu Ser Val His Thr Trp Gln Asp His Gly Tyr
             180                 185                 190

 tta gca acc tac aca aaa aag aac ggc agc ttt gcc aat ttg aga att      624
 Leu Ala Thr Tyr Thr Lys Lys Asn Gly Ser Phe Ala Asn Leu Arg Ile
         195                 200                 205

 tac cca cat gga ttg gtg ttg ctg gac ctt cag agt tat gat ggt gat      672
 Tyr Pro His Gly Leu Val Leu Leu Asp Leu Gln Ser Tyr Asp Gly Asp
     210                 215                 220

 gtg caa ggc aaa gaa gag atc gac agt att ttg aac aaa gta gaa gaa      720
 Val Gln Gly Lys Glu Glu Ile Asp Ser Ile Leu Asn Lys Val Glu Glu
 225                 230                 235                 240

 aga atg aaa gaa ttg agt cag gac agt act ggg cgg gtg aaa cga tta      768
 Arg Met Lys Glu Leu Ser Gln Asp Ser Thr Gly Arg Val Lys Arg Leu
                 245                 250                 255

 cca ccc ata gtg cga gga gga gcc att gac aga tac tgg ctc acc gcc      816
 Pro Pro Ile Val Arg Gly Gly Ala Ile Asp Arg Tyr Trp Leu Thr Ala
             260                 265                 270

 gat ggg cgc ctg gtt gaa tat gac ata gat gaa gtg ttt gga aat att      864
 Asp Gly Arg Leu Val Glu Tyr Asp Ile Asp Glu Val Phe Gly Asn Ile
         275                 280                 285

 ctc atc gtt agt ggg gat gtt aat ttg gca gag agt gat ttg gca tat      912
 Leu Ile Val Ser Gly Asp Val Asn Leu Ala Glu Ser Asp Leu Ala Tyr
     290                 295                 300

 acc cgg gcc atc atg ggc agt ggc gaa gaa gat tac act ggc aaa gat      960
 Thr Arg Ala Ile Met Gly Ser Gly Glu Glu Asp Tyr Thr Gly Lys Asp
 305                 310                 315                 320

 gta ctc att ctg gga ggt gga gat gga ggc ata ttg tgt gaa ata gtc     1008
 Val Leu Ile Leu Gly Gly Gly Asp Gly Gly Ile Leu Cys Glu Ile Val
                 325                 330                 335

 aaa cta aaa cca aag atg gtc act atg gta gag att gac gaa atg gtg     1056
 Lys Leu Lys Pro Lys Met Val Thr Met Val Glu Ile Asp Glu Met Val
             340                 345                 350

 att gat ggg tgt aag aaa tac atg caa aaa acg tat ggc gat gtc tta     1104
 Ile Asp Gly Cys Lys Lys Tyr Met Gln Lys Thr Tyr Gly Asp Val Leu
         355                 360                 365

 gac aat ctt aaa gga gac tgc tat cag gtt cta ata gaa gac tgt att     1152
 Asp Asn Leu Lys Gly Asp Cys Tyr Gln Val Leu Ile Glu Asp Cys Ile
     370                 375                 380

 ccg gta ctc aag agc cta atc aag gaa atg acg gtc ctc aca aga cta     1200
 Pro Val Leu Lys Ser Leu Ile Lys Glu Met Thr Val Leu Thr Arg Leu
 385                 390                 395                 400

 gta act aca gag tgg agt gct gct gca gac aaa ttc acg gtc tcc aca     1248
 Val Thr Thr Glu Trp Ser Ala Ala Ala Asp Lys Phe Thr Val Ser Thr
                 405                 410                 415

 act gta tca gcc agc gag aaa aac cag cag tgg gaa ggc cct cga cag     1296
 Thr Val Ser Ala Ser Glu Lys Asn Gln Gln Trp Glu Gly Pro Arg Gln
             420                 425                 430

 ttg gat gat aca tgc cca caa cag tga                                 1323
 Leu Asp Asp Thr Cys Pro Gln Gln 
         435                 440





      <210> 617
      <211> 1248
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (1)..(1248)

      <400> 617
  atg cgg ctg ggc ccg agg acc gcg gcg ttg ggg ctg ctg ctg ctg tgc      48
  Met Arg Leu Gly Pro Arg Thr Ala Ala Leu Gly Leu Leu Leu Leu Cys
    1               5                  10                  15

 gcc gcc gcg gcc ggc gcc ggc aag gcc gag gag ctg cac tac ccg ctg       96
 Ala Ala Ala Ala Gly Ala Gly Lys Ala Glu Glu Leu His Tyr Pro Leu
              20                  25                  30

 ggc gag cgc cgc agc gac tac gac cgc gag gcg ctg ctg ggc gtc cag      144
 Gly Glu Arg Arg Ser Asp Tyr Asp Arg Glu Ala Leu Leu Gly Val Gln
          35                  40                  45

 gaa gat gtg gat gaa tat gtt aaa ctc ggc cac gaa gag cag caa aaa      192
 Glu Asp Val Asp Glu Tyr Val Lys Leu Gly His Glu Glu Gln Gln Lys
      50                  55                  60

 aga ctg cag gcg atc ata aag aaa atc gac ttg gac tca gat ggc ttt      240
 Arg Leu Gln Ala Ile Ile Lys Lys Ile Asp Leu Asp Ser Asp Gly Phe
  65                  70                  75                  80

 ctc act gaa agt aag gac tgc cct aca cga cta aca atg gag aca aac      288
 Leu Thr Glu Ser Lys Asp Cys Pro Thr Arg Leu Thr Met Glu Thr Asn
                  85                  90                  95

 aca aat atg tta agc agc gag aag gtt tgg aaa tcc tta ctc tta agt      336
 Thr Asn Met Leu Ser Ser Glu Lys Val Trp Lys Ser Leu Leu Leu Ser
             100                 105                 110

 atc aga att aac gtc aca tgc gtt gtg ttc tgg gaa att ctc ata ggt      384
 Ile Arg Ile Asn Val Thr Cys Val Val Phe Trp Glu Ile Leu Ile Gly
         115                 120                 125

 gaa ctc agt tca tgg att cag atg tct ttt aag cat tat gct atg caa      432
 Glu Leu Ser Ser Trp Ile Gln Met Ser Phe Lys His Tyr Ala Met Gln
     130                 135                 140

 gaa gca aaa caa cag ttt gtt gaa tat gat aaa aac agt gat gat act      480
 Glu Ala Lys Gln Gln Phe Val Glu Tyr Asp Lys Asn Ser Asp Asp Thr
 145                 150                 155                 160

 gtg act tgg gat gaa tat aac att cag atg tat gat cgt gtg att gac      528
 Val Thr Trp Asp Glu Tyr Asn Ile Gln Met Tyr Asp Arg Val Ile Asp
                 165                 170                 175

 ttt gat gag aac act gct ctg gat gat gca gaa gag gag tcc ttt agg      576
 Phe Asp Glu Asn Thr Ala Leu Asp Asp Ala Glu Glu Glu Ser Phe Arg
             180                 185                 190

 aag gaa ttt gcc att tgt aaa aaa cag tct ttc tgt ttt tgg ctt ctt      624
 Lys Glu Phe Ala Ile Cys Lys Lys Gln Ser Phe Cys Phe Trp Leu Leu
         195                 200                 205

 cga ttt aat gtg agc tat tct tat ttt gtg ttc ttc aaa tgg cct ttg      672
 Arg Phe Asn Val Ser Tyr Ser Tyr Phe Val Phe Phe Lys Trp Pro Leu
     210                 215                 220

 ata gat gag gaa acc aga gag gtt aag cag ttt gcg ctg aca cca cag      720
 Ile Asp Glu Glu Thr Arg Glu Val Lys Gln Phe Ala Leu Thr Pro Gln
 225                 230                 235                 240

 cta gta agt ggc att gct gga att cag gtc tgg gtc tat atg act cta      768
 Leu Val Ser Gly Ile Ala Gly Ile Gln Val Trp Val Tyr Met Thr Leu
                 245                 250                 255

 gag ctt gac aag aag cga ttt gaa aaa gct aac cag gat tca ggt ccc      816
 Glu Leu Asp Lys Lys Arg Phe Glu Lys Ala Asn Gln Asp Ser Gly Pro
             260                 265                 270

 ggt ttg agt ctt gaa gaa ttt att gct ttt gag cat cct gaa gaa gtt      864
 Gly Leu Ser Leu Glu Glu Phe Ile Ala Phe Glu His Pro Glu Glu Val
         275                 280                 285

 gat tat atg acg gtg gat ctt aaa aga gat aga aac ata aaa cac tac      912
 Asp Tyr Met Thr Val Asp Leu Lys Arg Asp Arg Asn Ile Lys His Tyr
     290                 295                 300

 aaa tac tgg tgt aaa cac agt atc aga agc tta gta gaa gct gca aat      960
 Lys Tyr Trp Cys Lys His Ser Ile Arg Ser Leu Val Glu Ala Ala Asn
 305                 310                 315                 320

 gaa gat cca gaa tgg ata ctt gtt gag aaa gac aga ttc gtg aat gat     1008
 Glu Asp Pro Glu Trp Ile Leu Val Glu Lys Asp Arg Phe Val Asn Asp
                 325                 330                 335

 tat gac aaa gat aac gat ggc agg ctt gat ccc caa gag ctg tta cct     1056
 Tyr Asp Lys Asp Asn Asp Gly Arg Leu Asp Pro Gln Glu Leu Leu Pro
             340                 345                 350

 tgg gta gta cct aat aat cag ggc att gca caa gag gag gcg ctt cat     1104
 Trp Val Val Pro Asn Asn Gln Gly Ile Ala Gln Glu Glu Ala Leu His
         355                 360                 365

 cta att gat gaa atg gat ttg aat ggt gac aaa aag ctc tct gaa gaa     1152
 Leu Ile Asp Glu Met Asp Leu Asn Gly Asp Lys Lys Leu Ser Glu Glu
     370                 375                 380

 gag att ctg gaa aac ccg gac ttg ttt ctc acc agt gaa gcc aca gat     1200
 Glu Ile Leu Glu Asn Pro Asp Leu Phe Leu Thr Ser Glu Ala Thr Asp
 385                 390                 395                 400

 tat ggc aga cag ctc cat gat gac tat ttc tat cat gat gag ctt taa     1248
 Tyr Gly Arg Gln Leu His Asp Asp Tyr Phe Tyr His Asp Glu Leu 
                 405                 410                 415





      <210> 618
      <211> 1431
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (1)..(1431)

      <400> 618
  atg ttg ggg ctg gca aaa cga gtc ggt gcc cgt ctg ctc ctg gcc tcc      48
  Met Leu Gly Leu Ala Lys Arg Val Gly Ala Arg Leu Leu Leu Ala Ser
    1               5                  10                  15

 aca tcg gag gtg tat gga gat cct gaa gtc cac cct caa agt gag gat       96
 Thr Ser Glu Val Tyr Gly Asp Pro Glu Val His Pro Gln Ser Glu Asp
              20                  25                  30

 tac tgg ggc cac gtg aat cca ata gga cct cgg gcc tgc tac gat gaa      144
 Tyr Trp Gly His Val Asn Pro Ile Gly Pro Arg Ala Cys Tyr Asp Glu
          35                  40                  45

 ggc aaa cgt gtt gca gag acc atg tgc tat gcc tac atg aag cag ggt      192
 Gly Lys Arg Val Ala Glu Thr Met Cys Tyr Ala Tyr Met Lys Gln Gly
      50                  55                  60

 ggt gca gga gcc aat gaa ctg tgc aga gaa ggt gga ggc ctg ggc aca      240
 Gly Ala Gly Ala Asn Glu Leu Cys Arg Glu Gly Gly Gly Leu Gly Thr
  65                  70                  75                  80

 gga tat ccc att cat gtt ctc act gag tgt gtc ctt ggg ctt ggg tct      288
 Gly Tyr Pro Ile His Val Leu Thr Glu Cys Val Leu Gly Leu Gly Ser
                  85                  90                  95

 gaa ttt tca cat cct cat gaa aat gcc ctc tgg tat agt ggg aca tgc      336
 Glu Phe Ser His Pro His Glu Asn Ala Leu Trp Tyr Ser Gly Thr Cys
             100                 105                 110

 agg ctg aag cag gaa ggc gtg gaa gtg cga gtg gcc aga atc ttc aac      384
 Arg Leu Lys Gln Glu Gly Val Glu Val Arg Val Ala Arg Ile Phe Asn
         115                 120                 125

 acc ttt ggg cca cgc atg cac atg aac gat ggg cga gta gtc agc aac      432
 Thr Phe Gly Pro Arg Met His Met Asn Asp Gly Arg Val Val Ser Asn
     130                 135                 140

 ttc atc ctg cag gcg ctc cag ggg gag cca ctc acg ccg gcc tgt gaa      480
 Phe Ile Leu Gln Ala Leu Gln Gly Glu Pro Leu Thr Pro Ala Cys Glu
 145                 150                 155                 160

 gac ctt ctc cga cat act ttt ggc ctg ctg gct gta gcc agg ggc cct      528
 Asp Leu Leu Arg His Thr Phe Gly Leu Leu Ala Val Ala Arg Gly Pro
                 165                 170                 175

 cgg tac cat cct cca ctg gcc acc ctc aac cca ggg aga ctt ctg gag      576
 Arg Tyr His Pro Pro Leu Ala Thr Leu Asn Pro Gly Arg Leu Leu Glu
             180                 185                 190

 cca gca gag gtc cca gtg atc tgt ggt cgg tgg tcc aag tgt gtg gca      624
 Pro Ala Glu Val Pro Val Ile Cys Gly Arg Trp Ser Lys Cys Val Ala
         195                 200                 205

 aag atg tct gtg ccg aca ctg act gct tgg tac cct cag ata cca tct      672
 Lys Met Ser Val Pro Thr Leu Thr Ala Trp Tyr Pro Gln Ile Pro Ser
     210                 215                 220

 ggg gtc agg act ggt gag ccc acc atc aca gtg gcc ctg act gag tgt      720
 Gly Val Arg Thr Gly Glu Pro Thr Ile Thr Val Ala Leu Thr Glu Cys
 225                 230                 235                 240

 ggt ggg aag gtg caa aac aag cag cag agg tgc atc tgt gcg ctc agc      768
 Gly Gly Lys Val Gln Asn Lys Gln Gln Arg Cys Ile Cys Ala Leu Ser
                 245                 250                 255

 ttt gag agc aga gcc ccg gat gca gac aga ggc aat ggg cag gac agc      816
 Phe Glu Ser Arg Ala Pro Asp Ala Asp Arg Gly Asn Gly Gln Asp Ser
             260                 265                 270

 agc aca gcc cca aac cca cct gtg gag gag cct gtg acg cgg gag ttg      864
 Ser Thr Ala Pro Asn Pro Pro Val Glu Glu Pro Val Thr Arg Glu Leu
         275                 280                 285

 cct aaa tcc gat act cac tac agt gag gga ggt aca caa gca aac aaa      912
 Pro Lys Ser Asp Thr His Tyr Ser Glu Gly Gly Thr Gln Ala Asn Lys
     290                 295                 300

 acc ccc gag ggc act ctt gtt cct gtg atg ccg cgc tta gga gat ctc      960
 Thr Pro Glu Gly Thr Leu Val Pro Val Met Pro Arg Leu Gly Asp Leu
 305                 310                 315                 320

 ccc aag cac ctc tgt tgc cgt ctc cgc ctc agt ata cgg atc cgg gtc     1008
 Pro Lys His Leu Cys Cys Arg Leu Arg Leu Ser Ile Arg Ile Arg Val
                 325                 330                 335

 tca gac aag ggc gtt cca gta cgt cag agc cac act tta aag ctt ctg     1056
 Ser Asp Lys Gly Val Pro Val Arg Gln Ser His Thr Leu Lys Leu Leu
             340                 345                 350

 aaa ata aga acc aaa cct tgc gat cta gtg aat ggc ctc gtg gct ctc     1104
 Lys Ile Arg Thr Lys Pro Cys Asp Leu Val Asn Gly Leu Val Ala Leu
         355                 360                 365

 atg aac agc aac gtc agc agc ccg gtc aac ctg ggg aac cca gaa gaa     1152
 Met Asn Ser Asn Val Ser Ser Pro Val Asn Leu Gly Asn Pro Glu Glu
     370                 375                 380

 cac aca atc cta gaa ttt gct cag tta att aaa aac ctt gtt ggt agc     1200
 His Thr Ile Leu Glu Phe Ala Gln Leu Ile Lys Asn Leu Val Gly Ser
 385                 390                 395                 400

 gga agt gaa att cag ttt ctc tcc gaa gcc cag gat gac cca cag aaa     1248
 Gly Ser Glu Ile Gln Phe Leu Ser Glu Ala Gln Asp Asp Pro Gln Lys
                 405                 410                 415

 aga aaa cca gac atc aaa aaa gca aag ctg atg ctg ggg tgg gag ccc     1296
 Arg Lys Pro Asp Ile Lys Lys Ala Lys Leu Met Leu Gly Trp Glu Pro
             420                 425                 430

 gtg gtc ccg ctg gag gaa ggt tta aac aaa gca att cac tac ttc cgt     1344
 Val Val Pro Leu Glu Glu Gly Leu Asn Lys Ala Ile His Tyr Phe Arg
         435                 440                 445

 aaa gaa ctc gag tac cag gca aat aat cag tac atc ccc aaa cca aag     1392
 Lys Glu Leu Glu Tyr Gln Ala Asn Asn Gln Tyr Ile Pro Lys Pro Lys
     450                 455                 460

 cct gcc aga ata aag aaa gga cgg act cgc cac agc tga                 1431
 Pro Ala Arg Ile Lys Lys Gly Arg Thr Arg His Ser 
 465                 470                 475





      <210> 619
      <211> 2091
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (1)..(2091)

      <220>
      <221> misc_feature
      <222> (1)...(2091)
      <223> n = a,t,c or g

      <400> 619
  atg cct gga atg ccg aga tgc caa gga aca tac ctt gga aaa tgt gca      48
  Met Pro Gly Met Pro Arg Cys Gln Gly Thr Tyr Leu Gly Lys Cys Ala
    1               5                  10                  15

 gtt ctg ctt cga ttc ttg tca tca gct tcc tac aaa aat aca aaa tac       96
 Val Leu Leu Arg Phe Leu Ser Ser Ala Ser Tyr Lys Asn Thr Lys Tyr
              20                  25                  30

 cat cag aga ata tat aaa cac ctc tac aca aat aaa cta gaa aat cta      144
 His Gln Arg Ile Tyr Lys His Leu Tyr Thr Asn Lys Leu Glu Asn Leu
          35                  40                  45

 gaa gaa att gat aaa ttc ctc aac aca tac act ctc cca aga cta aac      192
 Glu Glu Ile Asp Lys Phe Leu Asn Thr Tyr Thr Leu Pro Arg Leu Asn
      50                  55                  60

 cag gaa gaa gtt gaa tcg ctg aat aga cca ata aca gga gct gaa att      240
 Gln Glu Glu Val Glu Ser Leu Asn Arg Pro Ile Thr Gly Ala Glu Ile
  65                  70                  75                  80

 gtg gca ata atc aat agc tta cca acc aaa agg agt cca gga cca gat      288
 Val Ala Ile Ile Asn Ser Leu Pro Thr Lys Arg Ser Pro Gly Pro Asp
                  85                  90                  95

 gga ttc aca gcc aaa ttc tac cag agg tac aag gag gaa ctg gta cca      336
 Gly Phe Thr Ala Lys Phe Tyr Gln Arg Tyr Lys Glu Glu Leu Val Pro
             100                 105                 110

 ttc ctt ctg aaa cta ttc caa tca ata gaa aaa gag gga atc ctc cct      384
 Phe Leu Leu Lys Leu Phe Gln Ser Ile Glu Lys Glu Gly Ile Leu Pro
         115                 120                 125

 aac tca ttn tat gag gcc agc atc atc ctg ata cca aag ccg ggc aga      432
 Asn Ser XXX Tyr Glu Ala Ser Ile Ile Leu Ile Pro Lys Pro Gly Arg
     130                 135                 140

 gac aca acc aaa aaa gag aat ttt aga cca ata tcc ttg att aac att      480
 Asp Thr Thr Lys Lys Glu Asn Phe Arg Pro Ile Ser Leu Ile Asn Ile
 145                 150                 155                 160

 gat gca aaa atc ctc aat aaa ata cta gca aac cga atc cag tgg cac      528
 Asp Ala Lys Ile Leu Asn Lys Ile Leu Ala Asn Arg Ile Gln Trp His
                 165                 170                 175

 atc aaa aag ctt atc cac cat gat caa gtg ggc ttc atc cct ggg atg      576
 Ile Lys Lys Leu Ile His His Asp Gln Val Gly Phe Ile Pro Gly Met
             180                 185                 190

 caa ggc tgg ttc aac ata cgc aaa tca ata aat gga atc cag cat ata      624
 Gln Gly Trp Phe Asn Ile Arg Lys Ser Ile Asn Gly Ile Gln His Ile
         195                 200                 205

 aac aga acc aaa gac aaa aac cac atg atg atc tca ata gat gca gaa      672
 Asn Arg Thr Lys Asp Lys Asn His Met Met Ile Ser Ile Asp Ala Glu
     210                 215                 220

 aag gcc ttt gac aaa att caa cag ccc ttc atg cta caa aca ctc aat      720
 Lys Ala Phe Asp Lys Ile Gln Gln Pro Phe Met Leu Gln Thr Leu Asn
 225                 230                 235                 240

 aaa tta ggt att gat ggg acg tac ctc aaa ata ata aga gct atc tat      768
 Lys Leu Gly Ile Asp Gly Thr Tyr Leu Lys Ile Ile Arg Ala Ile Tyr
                 245                 250                 255

 gac aaa ccc aca gcc aat atc aca ctg aat ggg caa aaa ctg gaa gca      816
 Asp Lys Pro Thr Ala Asn Ile Thr Leu Asn Gly Gln Lys Leu Glu Ala
             260                 265                 270

 ttc cct ttg aaa acg ggc aga aga cag aga tgc cct ctc tca cca ctc      864
 Phe Pro Leu Lys Thr Gly Arg Arg Gln Arg Cys Pro Leu Ser Pro Leu
         275                 280                 285

 cta ttc aac ata gtg ttg gaa gtt ctg gcc agg gca att agg cag gag      912
 Leu Phe Asn Ile Val Leu Glu Val Leu Ala Arg Ala Ile Arg Gln Glu
     290                 295                 300

 aaa gaa ata aag ggt aat caa tta gga aaa gag gaa gtc aaa ttg tcc      960
 Lys Glu Ile Lys Gly Asn Gln Leu Gly Lys Glu Glu Val Lys Leu Ser
 305                 310                 315                 320

 atg ttt gca ggt gac atg att gta tat tta gaa aac ccc atc gtc tca     1008
 Met Phe Ala Gly Asp Met Ile Val Tyr Leu Glu Asn Pro Ile Val Ser
                 325                 330                 335

 gcc caa aat ctc ctt aag ctg ata ggc aac ttc agc aag ttc tca gga     1056
 Ala Gln Asn Leu Leu Lys Leu Ile Gly Asn Phe Ser Lys Phe Ser Gly
             340                 345                 350

 tac aaa atc aat gtg caa aaa tcc caa gcc ttc tta tac acc aac aac     1104
 Tyr Lys Ile Asn Val Gln Lys Ser Gln Ala Phe Leu Tyr Thr Asn Asn
         355                 360                 365

 aga caa aca gag aac caa atc atg agt gaa ctc cca ttc aca att gca     1152
 Arg Gln Thr Glu Asn Gln Ile Met Ser Glu Leu Pro Phe Thr Ile Ala
     370                 375                 380

 tca aag aga ata aaa tac cta gga atc caa ctt aca agg gat gtg aag     1200
 Ser Lys Arg Ile Lys Tyr Leu Gly Ile Gln Leu Thr Arg Asp Val Lys
 385                 390                 395                 400

 gac ctc ttc aag gag aac tat aaa cca ctg ctc aac gaa ata aaa gag     1248
 Asp Leu Phe Lys Glu Asn Tyr Lys Pro Leu Leu Asn Glu Ile Lys Glu
                 405                 410                 415

 gat aca aac aaa tgg aag aac att cca tgc tca tgg ata gga aga atc     1296
 Asp Thr Asn Lys Trp Lys Asn Ile Pro Cys Ser Trp Ile Gly Arg Ile
             420                 425                 430

 aat att gtg aaa atg gcc ata ctg ccc aag gta att tat aga ttc aat     1344
 Asn Ile Val Lys Met Ala Ile Leu Pro Lys Val Ile Tyr Arg Phe Asn
         435                 440                 445

 gcc atc ccc atc aag cta cca acg act ttc ttc aca gaa ttg gaa aaa     1392
 Ala Ile Pro Ile Lys Leu Pro Thr Thr Phe Phe Thr Glu Leu Glu Lys
     450                 455                 460

 act act tta aag ttc cta tgg aac caa aaa aga gcc cac att gcc aag     1440
 Thr Thr Leu Lys Phe Leu Trp Asn Gln Lys Arg Ala His Ile Ala Lys
 465                 470                 475                 480

 aca atc cta agc caa aag aac aaa gct gga ggc atc acg cta cct gac     1488
 Thr Ile Leu Ser Gln Lys Asn Lys Ala Gly Gly Ile Thr Leu Pro Asp
                 485                 490                 495

 ttc aaa cta tac tac aag gct aca gta acc aaa aca gcc tgg tat tgg     1536
 Phe Lys Leu Tyr Tyr Lys Ala Thr Val Thr Lys Thr Ala Trp Tyr Trp
             500                 505                 510

 tac caa aag aga gat ata gac caa tgg aac aga ata gag ctc tca gaa     1584
 Tyr Gln Lys Arg Asp Ile Asp Gln Trp Asn Arg Ile Glu Leu Ser Glu
         515                 520                 525

 ata ata cca cac atc tac aac cat ctg atc ttt gac aaa cct gac aaa     1632
 Ile Ile Pro His Ile Tyr Asn His Leu Ile Phe Asp Lys Pro Asp Lys
     530                 535                 540

 aac aag aaa tgg gga aag gat tcc gta ttt aat aaa cgg tgc tgg gaa     1680
 Asn Lys Lys Trp Gly Lys Asp Ser Val Phe Asn Lys Arg Cys Trp Glu
 545                 550                 555                 560

 aac tgg ctt gcc ata tgt aga aag ctg aaa ctg gat acc ttc ctt aca     1728
 Asn Trp Leu Ala Ile Cys Arg Lys Leu Lys Leu Asp Thr Phe Leu Thr
                 565                 570                 575

 cct tat aca aaa att aat tca aga tgg att aaa gac tta cat gtt aga     1776
 Pro Tyr Thr Lys Ile Asn Ser Arg Trp Ile Lys Asp Leu His Val Arg
             580                 585                 590

 cct aaa gcc ata aaa acc cta gaa gaa aac cta ggc aat acc att cag     1824
 Pro Lys Ala Ile Lys Thr Leu Glu Glu Asn Leu Gly Asn Thr Ile Gln
         595                 600                 605

 gac ata ggc atg ggc aag gac ttc acg tct gaa aca cca aaa gca atg     1872
 Asp Ile Gly Met Gly Lys Asp Phe Thr Ser Glu Thr Pro Lys Ala Met
     610                 615                 620

 gca aca aaa gcc aaa att gac aaa tgg gat cta att aca cta aag agc     1920
 Ala Thr Lys Ala Lys Ile Asp Lys Trp Asp Leu Ile Thr Leu Lys Ser
 625                 630                 635                 640

 ttc tgt aca gca aaa gaa act acc atc aga gtg aac agg caa cct aca     1968
 Phe Cys Thr Ala Lys Glu Thr Thr Ile Arg Val Asn Arg Gln Pro Thr
                 645                 650                 655

 gaa tgg gag aaa att ttt gca atc tac tca tgt gtc aaa ggg cta ata     2016
 Glu Trp Glu Lys Ile Phe Ala Ile Tyr Ser Cys Val Lys Gly Leu Ile
             660                 665                 670

 tcc aga atc tac aaa gaa ctc aaa ttt gca aga ata aaa caa ccc cat     2064
 Ser Arg Ile Tyr Lys Glu Leu Lys Phe Ala Arg Ile Lys Gln Pro His
         675                 680                 685

 tac aaa gtg ggc aaa gga tat gaa tag                                 2091
 Tyr Lys Val Gly Lys Gly Tyr Glu 
     690                 695





      <210> 620
      <211> 1029
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (1)..(1029)

      <400> 620
  atg atc atg gcc tgg ccc tta gtg ggc act cag ctc aca tct gct atg      48
  Met Ile Met Ala Trp Pro Leu Val Gly Thr Gln Leu Thr Ser Ala Met
    1               5                  10                  15

 aac gat ggg agt cct tcg gtg tgc ctg tgt gtg aac gat gaa ctc acg       96
 Asn Asp Gly Ser Pro Ser Val Cys Leu Cys Val Asn Asp Glu Leu Thr
              20                  25                  30

 gac tgg agc act gtg ctg aaa gag tca gca gcc tct tgg atc tct cag      144
 Asp Trp Ser Thr Val Leu Lys Glu Ser Ala Ala Ser Trp Ile Ser Gln
          35                  40                  45

 tgc ctc aga ggc aaa ctt ctc cag tgc aca gac gtg ggc tca ggc tgc      192
 Cys Leu Arg Gly Lys Leu Leu Gln Cys Thr Asp Val Gly Ser Gly Cys
      50                  55                  60

 ccc agg tcc tgg ctg ttt cta aag aag atg cag ccc ggg ctt gaa gac      240
 Pro Arg Ser Trp Leu Phe Leu Lys Lys Met Gln Pro Gly Leu Glu Asp
  65                  70                  75                  80

 aag ctc gtg ccg cag gtc ctg ctg ctt cta aag aag agc aag ccg ggc      288
 Lys Leu Val Pro Gln Val Leu Leu Leu Leu Lys Lys Ser Lys Pro Gly
                  85                  90                  95

 tgg aca aca ggc ctc agg ccc cgc tgt ggc ttc cgg tgg tct ttc tgg      336
 Trp Thr Thr Gly Leu Arg Pro Arg Cys Gly Phe Arg Trp Ser Phe Trp
             100                 105                 110

 ggg ggc cct ttg aaa cca ccc aat ggg cca gag gtt cac cag gtg atc      384
 Gly Gly Pro Leu Lys Pro Pro Asn Gly Pro Glu Val His Gln Val Ile
         115                 120                 125

 aac atg gcg acc tca gga tgc cgg aag gag caa atg ggc acg gaa aga      432
 Asn Met Ala Thr Ser Gly Cys Arg Lys Glu Gln Met Gly Thr Glu Arg
     130                 135                 140

 gaa cac cct cct tta agc caa tct ttc ccc agc cgg gtg ctc cga gcc      480
 Glu His Pro Pro Leu Ser Gln Ser Phe Pro Ser Arg Val Leu Arg Ala
 145                 150                 155                 160

 atg gcc gac acc atc ttc ggc agc ggg aat gat cag tgg gtt tgc ccc      528
 Met Ala Asp Thr Ile Phe Gly Ser Gly Asn Asp Gln Trp Val Cys Pro
                 165                 170                 175

 aat gac cgg cag ctt gcc ctt cga gcc aaa agc atc gaa gaa gct tat      576
 Asn Asp Arg Gln Leu Ala Leu Arg Ala Lys Ser Ile Glu Glu Ala Tyr
             180                 185                 190

 tat ctc cac ttt tca ggc agg aca cca gag cgg aga gga ctg cct gac      624
 Tyr Leu His Phe Ser Gly Arg Thr Pro Glu Arg Arg Gly Leu Pro Asp
         195                 200                 205

 agg agg aag cag caa aca cac agc agc cac caa ggc cac ccc atc tct      672
 Arg Arg Lys Gln Gln Thr His Ser Ser His Gln Gly His Pro Ile Ser
     210                 215                 220

 gaa gag ctg ctg caa ggc tca tta gag cag gtc tgg aag agg tcg ggg      720
 Glu Glu Leu Leu Gln Gly Ser Leu Glu Gln Val Trp Lys Arg Ser Gly
 225                 230                 235                 240

 gcc tgg ttc tac aaa ggg ctc ccc aag tat atc ttg ccc ctg aag acc      768
 Ala Trp Phe Tyr Lys Gly Leu Pro Lys Tyr Ile Leu Pro Leu Lys Thr
                 245                 250                 255

 cct ggc cga gct gat gac ccc cac ttc cga cct ttg ccc acg gaa ccg      816
 Pro Gly Arg Ala Asp Asp Pro His Phe Arg Pro Leu Pro Thr Glu Pro
             260                 265                 270

 gca gag cga gag ccc aga agc tct gag acc agc cgc atc tac acg tgg      864
 Ala Glu Arg Glu Pro Arg Ser Ser Glu Thr Ser Arg Ile Tyr Thr Trp
         275                 280                 285

 gcc cga gga aga gag gag gaa act gag gct gag aga agt ccg tca act      912
 Ala Arg Gly Arg Glu Glu Glu Thr Glu Ala Glu Arg Ser Pro Ser Thr
     290                 295                 300

 tgc aca gga cca cac tgc cag cga gtg aca gag cga gga ttt gag ccc      960
 Cys Thr Gly Pro His Cys Gln Arg Val Thr Glu Arg Gly Phe Glu Pro
 305                 310                 315                 320

 aag gcc cgt gct ctt aag ctg tgt gtt gtc acg tgg tat ccg gag gat     1008
 Lys Ala Arg Ala Leu Lys Leu Cys Val Val Thr Trp Tyr Pro Glu Asp
                 325                 330                 335

 cct cga ctt gtc aaa aac tga                                         1029
 Pro Arg Leu Val Lys Asn 
             340





      <210> 621
      <211> 2229
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (1)..(2229)

      <400> 621
  atg cct ctc agg aag aca ctc atc ctg act tgt ttc agc cga att ttg      48
  Met Pro Leu Arg Lys Thr Leu Ile Leu Thr Cys Phe Ser Arg Ile Leu
    1               5                  10                  15

 gac ctt cca tct cat gat gga ttg ttt ctg ggc ctg ctt gac att atg       96
 Asp Leu Pro Ser His Asp Gly Leu Phe Leu Gly Leu Leu Asp Ile Met
              20                  25                  30

 act tgg gta att gtt ctc caa gta aac gac cat agg tcc tta aga aaa      144
 Thr Trp Val Ile Val Leu Gln Val Asn Asp His Arg Ser Leu Arg Lys
          35                  40                  45

 gag act agg gag acc ttc acc att ggg aac ttc ctt gaa agg aca tgg      192
 Glu Thr Arg Glu Thr Phe Thr Ile Gly Asn Phe Leu Glu Arg Thr Trp
      50                  55                  60

 ctc ttc tct ttc aat cac tgg gtt ctg agt tta aga act gct tca ggc      240
 Leu Phe Ser Phe Asn His Trp Val Leu Ser Leu Arg Thr Ala Ser Gly
  65                  70                  75                  80

 cca gag aca aaa agc caa gaa tca tcg att ttc att ggg atg ggt ttc      288
 Pro Glu Thr Lys Ser Gln Glu Ser Ser Ile Phe Ile Gly Met Gly Phe
                  85                  90                  95

 ctg gcc tat gga agc gta ttc aga gcc atg aat att cta ccg tct ttt      336
 Leu Ala Tyr Gly Ser Val Phe Arg Ala Met Asn Ile Leu Pro Ser Phe
             100                 105                 110

 att cat tct gca gtc aaa gga cta tgc gat gtt tcc ggt atg gga gag      384
 Ile His Ser Ala Val Lys Gly Leu Cys Asp Val Ser Gly Met Gly Glu
         115                 120                 125

 act act gct gtg aat att att gaa cat acc ttt tgt gca tat atg gac      432
 Thr Thr Ala Val Asn Ile Ile Glu His Thr Phe Cys Ala Tyr Met Asp
     130                 135                 140

 atg gct ctt tca gtc ctg tta tgg aac atg cag cat gag agc tca ttt      480
 Met Ala Leu Ser Val Leu Leu Trp Asn Met Gln His Glu Ser Ser Phe
 145                 150                 155                 160

 tca agt gtg aag tac act att gtt gac tct agt gtt gcc tat gat tgc      528
 Ser Ser Val Lys Tyr Thr Ile Val Asp Ser Ser Val Ala Tyr Asp Cys
                 165                 170                 175

 tcc atg gca aag aag aga aca gct gaa gat cag gct ttg ggg gtt cca      576
 Ser Met Ala Lys Lys Arg Thr Ala Glu Asp Gln Ala Leu Gly Val Pro
             180                 185                 190

 gtc aac aaa agg aaa tcc ctg cta atg aag ccc cga cac tac agc cca      624
 Val Asn Lys Arg Lys Ser Leu Leu Met Lys Pro Arg His Tyr Ser Pro
         195                 200                 205

 aaa gca gac tgc caa gaa gac cgc agt gac agg aca gag gac gat ggc      672
 Lys Ala Asp Cys Gln Glu Asp Arg Ser Asp Arg Thr Glu Asp Asp Gly
     210                 215                 220

 ccc ttg gaa aca cat ggt cac tct acc gca gag gaa atc atg ata aaa      720
 Pro Leu Glu Thr His Gly His Ser Thr Ala Glu Glu Ile Met Ile Lys
 225                 230                 235                 240

 cct atg gat gaa agt ctt ctt tca act gca caa gaa aac tcc agt agg      768
 Pro Met Asp Glu Ser Leu Leu Ser Thr Ala Gln Glu Asn Ser Ser Arg
                 245                 250                 255

 aag gaa gac aga tac tct tgt tat caa gag ctc atg gtc aag tct tta      816
 Lys Glu Asp Arg Tyr Ser Cys Tyr Gln Glu Leu Met Val Lys Ser Leu
             260                 265                 270

 atg cac ttg ggg aaa ttt gaa aaa aat gta tct gtt cag act gta agt      864
 Met His Leu Gly Lys Phe Glu Lys Asn Val Ser Val Gln Thr Val Ser
         275                 280                 285

 gaa aat tta aat gac agt ggc atc cag tct tta aaa gca gag agc gat      912
 Glu Asn Leu Asn Asp Ser Gly Ile Gln Ser Leu Lys Ala Glu Ser Asp
     290                 295                 300

 gaa gca gac gag tgc ttt ctg att cat tct gat gat gga aga gac aag      960
 Glu Ala Asp Glu Cys Phe Leu Ile His Ser Asp Asp Gly Arg Asp Lys
 305                 310                 315                 320

 att gat gat tct cag cca ccc ttc tgc tcc tct gat gac aat gaa agt     1008
 Ile Asp Asp Ser Gln Pro Pro Phe Cys Ser Ser Asp Asp Asn Glu Ser
                 325                 330                 335

 aac tct gaa agt gca gaa aat ggc tgg gac agt ggc tcc aac ttc tca     1056
 Asn Ser Glu Ser Ala Glu Asn Gly Trp Asp Ser Gly Ser Asn Phe Ser
             340                 345                 350

 gaa gaa acc aaa cca cct aga gtc cca aag tat gtt tta aca gat cat     1104
 Glu Glu Thr Lys Pro Pro Arg Val Pro Lys Tyr Val Leu Thr Asp His
         355                 360                 365

 aaa aaa gac cta ttg gaa gtt cct gaa ata aaa act gaa ggt gac aaa     1152
 Lys Lys Asp Leu Leu Glu Val Pro Glu Ile Lys Thr Glu Gly Asp Lys
     370                 375                 380

 ttt atc cct tgt gag aac agg tgt gat tct gaa aca gaa agg aaa gac     1200
 Phe Ile Pro Cys Glu Asn Arg Cys Asp Ser Glu Thr Glu Arg Lys Asp
 385                 390                 395                 400

 ccg cag aat gct ctc gca gaa ccc ctg gat ggc aat gcc cag ccc tca     1248
 Pro Gln Asn Ala Leu Ala Glu Pro Leu Asp Gly Asn Ala Gln Pro Ser
                 405                 410                 415

 ttc cct gac gtt gag gag gaa gat agc gag agc ctg gca gta atg acg     1296
 Phe Pro Asp Val Glu Glu Glu Asp Ser Glu Ser Leu Ala Val Met Thr
             420                 425                 430

 gaa gag ggt agt gac ctg gaa aag gcc aag ggg aat tta agt ttg ctg     1344
 Glu Glu Gly Ser Asp Leu Glu Lys Ala Lys Gly Asn Leu Ser Leu Leu
         435                 440                 445

 gag cag gca att gct ctg cag gct gag cga ggt tgt gtt ttc cat aac     1392
 Glu Gln Ala Ile Ala Leu Gln Ala Glu Arg Gly Cys Val Phe His Asn
     450                 455                 460

 acc tac aaa gag ctg gat agg ttc ctg ctg gag cac cta gca ggg gaa     1440
 Thr Tyr Lys Glu Leu Asp Arg Phe Leu Leu Glu His Leu Ala Gly Glu
 465                 470                 475                 480

 agg agg caa acc aaa gtt atc gac atg ggt gga aga caa atc ttt aac     1488
 Arg Arg Gln Thr Lys Val Ile Asp Met Gly Gly Arg Gln Ile Phe Asn
                 485                 490                 495

 aat aaa cga ctg ttt atc atc cag caa ctg ggg tgc cat ggt atg gca     1536
 Asn Lys Arg Leu Phe Ile Ile Gln Gln Leu Gly Cys His Gly Met Ala
             500                 505                 510

 gag gca cgt ctg ctc tca caa tac agc acc ccg gaa atg tct gtc gca     1584
 Glu Ala Arg Leu Leu Ser Gln Tyr Ser Thr Pro Glu Met Ser Val Ala
         515                 520                 525

 tcc cgt gac agt ggc cag act tcg tgc ccc gtt gca cag gag cac acg     1632
 Ser Arg Asp Ser Gly Gln Thr Ser Cys Pro Val Ala Gln Glu His Thr
     530                 535                 540

 agg ctc cgc acc ctc gca cgc agg ccc cat gtt cca act ctt tct ggt     1680
 Arg Leu Arg Thr Leu Ala Arg Arg Pro His Val Pro Thr Leu Ser Gly
 545                 550                 555                 560

 tgt cca att gct gca gct gaa aaa ttg gca atg tcc cag gat aaa aat     1728
 Cys Pro Ile Ala Ala Ala Glu Lys Leu Ala Met Ser Gln Asp Lys Asn
                 565                 570                 575

 cag ctt gat tct ccc caa act ggg cag tgt cct gac cag gcc cac agg     1776
 Gln Leu Asp Ser Pro Gln Thr Gly Gln Cys Pro Asp Gln Ala His Arg
             580                 585                 590

 aca agt ttg gtg aag caa att gaa ttc aat ttc ccg tca caa gcc atc     1824
 Thr Ser Leu Val Lys Gln Ile Glu Phe Asn Phe Pro Ser Gln Ala Ile
         595                 600                 605

 acc tct ccc aga gcc aca gtg tca aaa gaa caa gag aag ttt gga aaa     1872
 Thr Ser Pro Arg Ala Thr Val Ser Lys Glu Gln Glu Lys Phe Gly Lys
     610                 615                 620

 gta cca ttt gat tat gcc agt ttt gat gcc caa gtt ttc ggt aaa cgc     1920
 Val Pro Phe Asp Tyr Ala Ser Phe Asp Ala Gln Val Phe Gly Lys Arg
 625                 630                 635                 640

 cct ctc ata caa aca gtg caa gga cga aaa aca cca cca ttt cct gaa     1968
 Pro Leu Ile Gln Thr Val Gln Gly Arg Lys Thr Pro Pro Phe Pro Glu
                 645                 650                 655

 tca aag cat ttt cca aat cca gtg aaa ttt cct aat cga ctg cct agt     2016
 Ser Lys His Phe Pro Asn Pro Val Lys Phe Pro Asn Arg Leu Pro Ser
             660                 665                 670

 gca ggc gcc cac acc cag agc cct ggc cgt gcc agc tct tat agc tac     2064
 Ala Gly Ala His Thr Gln Ser Pro Gly Arg Ala Ser Ser Tyr Ser Tyr
         675                 680                 685

 ggt caa tgt agt gaa gac acc cac ata gca gca gct gct gcc atc ctg     2112
 Gly Gln Cys Ser Glu Asp Thr His Ile Ala Ala Ala Ala Ala Ile Leu
     690                 695                 700

 aac ctt tcc acc cgc tgc agg gaa gcc aca gac atc ctc tcc aac aag     2160
 Asn Leu Ser Thr Arg Cys Arg Glu Ala Thr Asp Ile Leu Ser Asn Lys
 705                 710                 715                 720

 cca cag agt ctg cat gcc aag gta ggc cag tcc aag agc ccg gag ggt     2208
 Pro Gln Ser Leu His Ala Lys Val Gly Gln Ser Lys Ser Pro Glu Gly
                 725                 730                 735

 ggg cca gcg act gaa ctg tga                                         2229
 Gly Pro Ala Thr Glu Leu 
             740





      <210> 622
      <211> 2016
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (1)..(2016)

      <400> 622
  atg aag ttt gcc ttt gag gaa ttc cac ctg tgg tac cag ttt gct ctg      48
  Met Lys Phe Ala Phe Glu Glu Phe His Leu Trp Tyr Gln Phe Ala Leu
    1               5                  10                  15

 tcc ctg atg gct gct gga aaa gcc aaa gag ttg aat gtc atg gaa ttg       96
 Ser Leu Met Ala Ala Gly Lys Ala Lys Glu Leu Asn Val Met Glu Leu
              20                  25                  30

 cac gga atg ata gac ttt gtg gaa gtc ttt cga gcc act ctg aga aac      144
 His Gly Met Ile Asp Phe Val Glu Val Phe Arg Ala Thr Leu Arg Asn
          35                  40                  45

 tat cgt ggt ccg ttc tca tct gcc cgt gcc gtg aag gtg ctg aaa gag      192
 Tyr Arg Gly Pro Phe Ser Ser Ala Arg Ala Val Lys Val Leu Lys Glu
      50                  55                  60

 tgt atc cgc ctg aag cca gac gat gcc acc atc cct ctc ctc gct gcc      240
 Cys Ile Arg Leu Lys Pro Asp Asp Ala Thr Ile Pro Leu Leu Ala Ala
  65                  70                  75                  80

 aag ctc tgc atg ggc tcc ctg cac tgg ttg gaa gag gct gaa aag ttt      288
 Lys Leu Cys Met Gly Ser Leu His Trp Leu Glu Glu Ala Glu Lys Phe
                  85                  90                  95

 gcc aaa act gtc gtt gat gtg gga gag aaa acg tca gag ttc aag gcc      336
 Ala Lys Thr Val Val Asp Val Gly Glu Lys Thr Ser Glu Phe Lys Ala
             100                 105                 110

 aaa ggc tac tta gct ctg ggg ctc acg tac agt ctg cag gcc act gac      384
 Lys Gly Tyr Leu Ala Leu Gly Leu Thr Tyr Ser Leu Gln Ala Thr Asp
         115                 120                 125

 ggc tct cac atc cta ctg aga aaa gcc atc ctg aaa aca gtt gag agc      432
 Gly Ser His Ile Leu Leu Arg Lys Ala Ile Leu Lys Thr Val Glu Ser
     130                 135                 140

 acc ttt cat tgc atg gcc cac act gtt ctg ggg atg ttg gcc aca tgc      480
 Thr Phe His Cys Met Ala His Thr Val Leu Gly Met Leu Ala Thr Cys
 145                 150                 155                 160

 ctg ccc acc cac cag gtg caa gac act ggt ggt aac ccc agc aca ttc      528
 Leu Pro Thr His Gln Val Gln Asp Thr Gly Gly Asn Pro Ser Thr Phe
                 165                 170                 175

 ctg agt gct gac tgg gag ggt gat tca aag gtc agc tct cca gac atg      576
 Leu Ser Ala Asp Trp Glu Gly Asp Ser Lys Val Ser Ser Pro Asp Met
             180                 185                 190

 cca ttc ccc tgg cag gcc tgg gct gag atc cca gag gct ctg ggg tat      624
 Pro Phe Pro Trp Gln Ala Trp Ala Glu Ile Pro Glu Ala Leu Gly Tyr
         195                 200                 205

 gtc cgc caa gct ctt cag ctt caa ggt gac gat gcc aac tcc ctg cac      672
 Val Arg Gln Ala Leu Gln Leu Gln Gly Asp Asp Ala Asn Ser Leu His
     210                 215                 220

 ctc ctt gcc ctc ctg ctg tca gca cag aag cat tac cat gac gct ctg      720
 Leu Leu Ala Leu Leu Leu Ser Ala Gln Lys His Tyr His Asp Ala Leu
 225                 230                 235                 240

 aac atc atc gac atg gcc ctg agt gaa tac cca gaa aat ttc ata cta      768
 Asn Ile Ile Asp Met Ala Leu Ser Glu Tyr Pro Glu Asn Phe Ile Leu
                 245                 250                 255

 ctg ttt tcc aaa gtg aag ttg cag tca ctc tgc cga ggc ccg gac gag      816
 Leu Phe Ser Lys Val Lys Leu Gln Ser Leu Cys Arg Gly Pro Asp Glu
             260                 265                 270

 gca ctg ctg act tgt aag cac atg ctg cag ata tgg aaa tcc tgc tac      864
 Ala Leu Leu Thr Cys Lys His Met Leu Gln Ile Trp Lys Ser Cys Tyr
         275                 280                 285

 aac ctc acc aac ccc agc tgg aag tcc cct tcc caa gca cag gaa cag      912
 Asn Leu Thr Asn Pro Ser Trp Lys Ser Pro Ser Gln Ala Gln Glu Gln
     290                 295                 300

 cgg cgc ggc gct gtg ctg ctg ggc gca ccc gcc ctt cgc ttg gtg aaa      960
 Arg Arg Gly Ala Val Leu Leu Gly Ala Pro Ala Leu Arg Leu Val Lys
 305                 310                 315                 320

 gag tct tct caa aaa cct ctc aca ggc tcc gtc cat gcc aca tcg gta     1008
 Glu Ser Ser Gln Lys Pro Leu Thr Gly Ser Val His Ala Thr Ser Val
                 325                 330                 335

 gca gcc tca aga gtg gag cag gca ctg tcg gaa gtg gct tcg tct ctg     1056
 Ala Ala Ser Arg Val Glu Gln Ala Leu Ser Glu Val Ala Ser Ser Leu
             340                 345                 350

 cag agc agt gcc cct aag cag ggc ccg ctg cac ccc tgg atg acg ctg     1104
 Gln Ser Ser Ala Pro Lys Gln Gly Pro Leu His Pro Trp Met Thr Leu
         355                 360                 365

 gca cag atc tgg ctc cat gca gaa ggt ggt gga att gaa cta tgg aaa     1152
 Ala Gln Ile Trp Leu His Ala Glu Gly Gly Gly Ile Glu Leu Trp Lys
     370                 375                 380

 gtg act gtc gac cct gta aac cct gag cag act gtg ctg tat gca tac     1200
 Val Thr Val Asp Pro Val Asn Pro Glu Gln Thr Val Leu Tyr Ala Tyr
 385                 390                 395                 400

 gga tac gcc agt ggt caa ggc aag agt gct gag gaa ggg tct ggc ctg     1248
 Gly Tyr Ala Ser Gly Gln Gly Lys Ser Ala Glu Glu Gly Ser Gly Leu
                 405                 410                 415

 cag gtg gga gaa ggg gtc cat gag ccc cga cag agc ggg cgg cct ctg     1296
 Gln Val Gly Glu Gly Val His Glu Pro Arg Gln Ser Gly Arg Pro Leu
             420                 425                 430

 cgt gag gct ctg ggc tgc aga ctt gac cat gtg gcc ctg ctg gcc ctg     1344
 Arg Glu Ala Leu Gly Cys Arg Leu Asp His Val Ala Leu Leu Ala Leu
         435                 440                 445

 gag agg gct gaa gtc tat atc ggc atc ggg aag cct gca gaa gcc aca     1392
 Glu Arg Ala Glu Val Tyr Ile Gly Ile Gly Lys Pro Ala Glu Ala Thr
     450                 455                 460

 gcc tgt acc caa gaa gct gcc aac ctc ttc cca atg tcc cac aat gtc     1440
 Ala Cys Thr Gln Glu Ala Ala Asn Leu Phe Pro Met Ser His Asn Val
 465                 470                 475                 480

 ctc tac atg cgc ggc cag att gct gag ctc cgg gga agc atg gac gag     1488
 Leu Tyr Met Arg Gly Gln Ile Ala Glu Leu Arg Gly Ser Met Asp Glu
                 485                 490                 495

 gcg cgg cgg tgg tat gaa gag gcc tta gcc atc agc ccc acc cac gtg     1536
 Ala Arg Arg Trp Tyr Glu Glu Ala Leu Ala Ile Ser Pro Thr His Val
             500                 505                 510

 aag agc atg cag cga ctg gtc acc tgt aag tta gga gca gaa gca gaa     1584
 Lys Ser Met Gln Arg Leu Val Thr Cys Lys Leu Gly Ala Glu Ala Glu
         515                 520                 525

 caa gaa agt cgt gaa atc gta tgt tgg tgt ggt ccc tta gga acc cag     1632
 Gln Glu Ser Arg Glu Ile Val Cys Trp Cys Gly Pro Leu Gly Thr Gln
     530                 535                 540

 agc ttc agt gac agg cgg tgg aaa gat cgg gag cac ggg gct gat gca     1680
 Ser Phe Ser Asp Arg Arg Trp Lys Asp Arg Glu His Gly Ala Asp Ala
 545                 550                 555                 560

 att ggt gac ttt gag ttg aag cca gtg ttc att cac cgt ttt gaa aat     1728
 Ile Gly Asp Phe Glu Leu Lys Pro Val Phe Ile His Arg Phe Glu Asn
                 565                 570                 575

 cct agg gcc ctt aag aat tat gcg aaa ttg act ctg cct gtg ctc tgt     1776
 Pro Arg Ala Leu Lys Asn Tyr Ala Lys Leu Thr Leu Pro Val Leu Cys
             580                 585                 590

 aaa tgg aac aag aaa gcc tgg atg atg gca cac ctg ttt aaa gca tgg     1824
 Lys Trp Asn Lys Lys Ala Trp Met Met Ala His Leu Phe Lys Ala Trp
         595                 600                 605

 ttc aat gac tat ttt atg ccc act gtt gac act tat tca gag aaa aag     1872
 Phe Asn Asp Tyr Phe Met Pro Thr Val Asp Thr Tyr Ser Glu Lys Lys
     610                 615                 620

 att cct ctc aaa ata tta ttg ttc agt gac aat gta ctt ggt tac cca     1920
 Ile Pro Leu Lys Ile Leu Leu Phe Ser Asp Asn Val Leu Gly Tyr Pro
 625                 630                 635                 640

 aga gct ctg ctg gag ttg tac aag gag atg act gtt atc ttc atg cct     1968
 Arg Ala Leu Leu Glu Leu Tyr Lys Glu Met Thr Val Ile Phe Met Pro
                 645                 650                 655

 gct aac aca gca tcc act tta cag ccc atg gat caa gga gcg att tag     2016
 Ala Asn Thr Ala Ser Thr Leu Gln Pro Met Asp Gln Gly Ala Ile 
             660                 665                 670





      <210> 623
      <211> 4275
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (1)..(4275)

      <400> 623
  atg tat ttg cac agt gta ttt tca ttt ttc tgt aca tat gta agt ggg      48
  Met Tyr Leu His Ser Val Phe Ser Phe Phe Cys Thr Tyr Val Ser Gly
    1               5                  10                  15

 agc tgg gtt tat aaa gag ggt cat gat acg gag aaa ggt ggt gaa tgt       96
 Ser Trp Val Tyr Lys Glu Gly His Asp Thr Glu Lys Gly Gly Glu Cys
              20                  25                  30

 aaa gaa aga tgt atg caa gaa tgc aaa ggt gtg ttc aca aga gac tct      144
 Lys Glu Arg Cys Met Gln Glu Cys Lys Gly Val Phe Thr Arg Asp Ser
          35                  40                  45

 gtt ggt ttc cct cca ggt ggg gag gag cac gtg ttt gag aat tcg ccg      192
 Val Gly Phe Pro Pro Gly Gly Glu Glu His Val Phe Glu Asn Ser Pro
      50                  55                  60

 gtc ctg gat gaa cgg tcc gcc ctc tac tct ggc gtg cac aag aag ccc      240
 Val Leu Asp Glu Arg Ser Ala Leu Tyr Ser Gly Val His Lys Lys Pro
  65                  70                  75                  80

 ctt ttc ttt gat ggc tct cct gag aaa cct ccc gaa gat gac tca gac      288
 Leu Phe Phe Asp Gly Ser Pro Glu Lys Pro Pro Glu Asp Asp Ser Asp
                  85                  90                  95

 tct ctc acc acg tct cca tcc tcc agc agc ctg gac acc tgg ggg gct      336
 Ser Leu Thr Thr Ser Pro Ser Ser Ser Ser Leu Asp Thr Trp Gly Ala
             100                 105                 110

 ggc cgg aag ttg gtc aaa acc ttc agc aaa gga gag agc cgg ggc ctg      384
 Gly Arg Lys Leu Val Lys Thr Phe Ser Lys Gly Glu Ser Arg Gly Leu
         115                 120                 125

 att aag ccc ccc aag aag atg ggg aca ttc ttc tcc tac cca gaa gaa      432
 Ile Lys Pro Pro Lys Lys Met Gly Thr Phe Phe Ser Tyr Pro Glu Glu
     130                 135                 140

 gaa aag gcc cag aaa gtg tcc cgc tcc ctc acc gag ggg gag atg aag      480
 Glu Lys Ala Gln Lys Val Ser Arg Ser Leu Thr Glu Gly Glu Met Lys
 145                 150                 155                 160

 aag ggt ctc ggg tcc cta agc cac ggg gta agt acg gat ggt gtt tgc      528
 Lys Gly Leu Gly Ser Leu Ser His Gly Val Ser Thr Asp Gly Val Cys
                 165                 170                 175

 ttc tat gac aac cac cgt cgc agg cac cac ctt ctg gtg tcc ctg gag      576
 Phe Tyr Asp Asn His Arg Arg Arg His His Leu Leu Val Ser Leu Glu
             180                 185                 190

 gag ttt cag agt gtc cgg aag caa atc cgc ttg aag aaa acg gat act      624
 Glu Phe Gln Ser Val Arg Lys Gln Ile Arg Leu Lys Lys Thr Asp Thr
         195                 200                 205

 aat tat tcc tgt tcc aga gct ttt ctc tgc cag cgt ccc tcc aga aaa      672
 Asn Tyr Ser Cys Ser Arg Ala Phe Leu Cys Gln Arg Pro Ser Arg Lys
     210                 215                 220

 ggc gtc acc agc acc acc tgt gac ctg cag ctg ctc cgg cag aaa ggc      720
 Gly Val Thr Ser Thr Thr Cys Asp Leu Gln Leu Leu Arg Gln Lys Gly
 225                 230                 235                 240

 aaa ggg ggc ggg agc tgc ggc ttc ccc ggc agg agg gtg cgc ggg cgc      768
 Lys Gly Gly Gly Ser Cys Gly Phe Pro Gly Arg Arg Val Arg Gly Arg
                 245                 250                 255

 acc tcg gtc agc gag ttc aat atc acc tac gtg gtg gag cgg agc ctg      816
 Thr Ser Val Ser Glu Phe Asn Ile Thr Tyr Val Val Glu Arg Ser Leu
             260                 265                 270

 tac agc cac ctg aac ctg acc cag cta gtg cgg cct gcc tca gac agg      864
 Tyr Ser His Leu Asn Leu Thr Gln Leu Val Arg Pro Ala Ser Asp Arg
         275                 280                 285

 acc ctg agc aag gct gag aga cag gac ctg agg cgg tgc ctg ctg gag      912
 Thr Leu Ser Lys Ala Glu Arg Gln Asp Leu Arg Arg Cys Leu Leu Glu
     290                 295                 300

 gag gat gag gag gca aag agg aag tgg gcc gcc acg gtc gac cgc tgt      960
 Glu Asp Glu Glu Ala Lys Arg Lys Trp Ala Ala Thr Val Asp Arg Cys
 305                 310                 315                 320

 act aaa agg gtt ctc ttg aga atc cac cag aag tct cga ttt aaa gct     1008
 Thr Lys Arg Val Leu Leu Arg Ile His Gln Lys Ser Arg Phe Lys Ala
                 325                 330                 335

 aaa caa aat gaa agt ctg ttt gaa aag ctt gct gtt ggt gtc aga gcc     1056
 Lys Gln Asn Glu Ser Leu Phe Glu Lys Leu Ala Val Gly Val Arg Ala
             340                 345                 350

 gtg gga ttt caa acc tgg gtt ttc agg atg cct gag tac atg gat cct     1104
 Val Gly Phe Gln Thr Trp Val Phe Arg Met Pro Glu Tyr Met Asp Pro
         355                 360                 365

 cta aca cat atc cct tca tta tct cta ctg aat gta gct gat gtt agg     1152
 Leu Thr His Ile Pro Ser Leu Ser Leu Leu Asn Val Ala Asp Val Arg
     370                 375                 380

 gga agt tct gtg ctg gag aca ggg aat ctc aca gca ctg gac tca tgg     1200
 Gly Ser Ser Val Leu Glu Thr Gly Asn Leu Thr Ala Leu Asp Ser Trp
 385                 390                 395                 400

 agg aga acc tgc agt ttt gga gga ttt gac ttg acg aat cgc tct ctg     1248
 Arg Arg Thr Cys Ser Phe Gly Gly Phe Asp Leu Thr Asn Arg Ser Leu
                 405                 410                 415

 cac gtt ggc agt aat aat tct gac cca atg ggt aaa gaa gga gac ttt     1296
 His Val Gly Ser Asn Asn Ser Asp Pro Met Gly Lys Glu Gly Asp Phe
             420                 425                 430

 gtg tac aaa gaa gtc atc aaa tca cct act gcc tct cgc atc tct ctt     1344
 Val Tyr Lys Glu Val Ile Lys Ser Pro Thr Ala Ser Arg Ile Ser Leu
         435                 440                 445

 ggg aaa aag gtg aaa tca gtg aaa gag acg atg aga aag aga atg tct     1392
 Gly Lys Lys Val Lys Ser Val Lys Glu Thr Met Arg Lys Arg Met Ser
     450                 455                 460

 aaa aaa tac agc agc tct gtc tct gag cag cct gtt gaa gtt cct gtg     1440
 Lys Lys Tyr Ser Ser Ser Val Ser Glu Gln Pro Val Glu Val Pro Val
 465                 470                 475                 480

 tat gag ctg gtt gtc tgc ttg aaa tat gta gcg tgc aac cta gat gcc     1488
 Tyr Glu Leu Val Val Cys Leu Lys Tyr Val Ala Cys Asn Leu Asp Ala
                 485                 490                 495

 tcg tgt gca caa ttc aca ata gga ttc gtg ctc cta cga gaa tct aat     1536
 Ser Cys Ala Gln Phe Thr Ile Gly Phe Val Leu Leu Arg Glu Ser Asn
             500                 505                 510

 acc gcc gct gat ctg aca gga ggt gga gct cag aca gta atg cgg ccc     1584
 Thr Ala Ala Asp Leu Thr Gly Gly Gly Ala Gln Thr Val Met Arg Pro
         515                 520                 525

 gac ccc gaa cac ttg gac aag ccc aag ctc aag gcc ggg ggt tct gta     1632
 Asp Pro Glu His Leu Asp Lys Pro Lys Leu Lys Ala Gly Gly Ser Val
     530                 535                 540

 gaa agt ctt cgc agt tct ctc agt ggg cag agc tcc atg agc ggt caa     1680
 Glu Ser Leu Arg Ser Ser Leu Ser Gly Gln Ser Ser Met Ser Gly Gln
 545                 550                 555                 560

 aca gtg agc acc act gat tcc tca acc agc aac cgg gaa agc gtc aag     1728
 Thr Val Ser Thr Thr Asp Ser Ser Thr Ser Asn Arg Glu Ser Val Lys
                 565                 570                 575

 tcg gaa gat ggg gat gac gaa gag ccg cct tac cga ggc ccg ttc tgc     1776
 Ser Glu Asp Gly Asp Asp Glu Glu Pro Pro Tyr Arg Gly Pro Phe Cys
             580                 585                 590

 ggg cgt gcc agg gtg cac acc gac ttc acc ccc agt ccc tat gac aca     1824
 Gly Arg Ala Arg Val His Thr Asp Phe Thr Pro Ser Pro Tyr Asp Thr
         595                 600                 605

 gac tca ctc aag ctc aag att ctt gat ttg tac gtt cat gga atg tac     1872
 Asp Ser Leu Lys Leu Lys Ile Leu Asp Leu Tyr Val His Gly Met Tyr
     610                 615                 620

 cta atg gaa aga tct ttg ctc cct ggg cca cag aaa gga gat atc atc     1920
 Leu Met Glu Arg Ser Leu Leu Pro Gly Pro Gln Lys Gly Asp Ile Ile
 625                 630                 635                 640

 gat ata atc agc aag cca ccc atg ggg acc tgg atg ggc ctg ctg aac     1968
 Asp Ile Ile Ser Lys Pro Pro Met Gly Thr Trp Met Gly Leu Leu Asn
                 645                 650                 655

 aac aaa gtc ggc acg ttc aag ttc atc tac gtg gac gtg ctc agt gaa     2016
 Asn Lys Val Gly Thr Phe Lys Phe Ile Tyr Val Asp Val Leu Ser Glu
             660                 665                 670

 gac gag gag aaa ccc aaa cgc ccc acc agg agg cgt cgg aaa gga cga     2064
 Asp Glu Glu Lys Pro Lys Arg Pro Thr Arg Arg Arg Arg Lys Gly Arg
         675                 680                 685

 cca ccc cag ccc aag tct gtg gag gat ctc ctg gat cgg att aac cta     2112
 Pro Pro Gln Pro Lys Ser Val Glu Asp Leu Leu Asp Arg Ile Asn Leu
     690                 695                 700

 aaa gag cac atg ccc act ttc ctg ttc aat gga tat gaa gat ttg gac     2160
 Lys Glu His Met Pro Thr Phe Leu Phe Asn Gly Tyr Glu Asp Leu Asp
 705                 710                 715                 720

 acc ttt aag ctg ctg gag gag gaa gac ttg gat gag tta aat atc agg     2208
 Thr Phe Lys Leu Leu Glu Glu Glu Asp Leu Asp Glu Leu Asn Ile Arg
                 725                 730                 735

 gac ccg gaa cac aga gct gtt ctc ttg aca gca gtg gag ctg tta caa     2256
 Asp Pro Glu His Arg Ala Val Leu Leu Thr Ala Val Glu Leu Leu Gln
             740                 745                 750

 gag tat gac agt aac agc gac cag tca gga tcc cag gag aag ctg ctc     2304
 Glu Tyr Asp Ser Asn Ser Asp Gln Ser Gly Ser Gln Glu Lys Leu Leu
         755                 760                 765

 gtt gac agc cag ggc ctg agt gga tgc tca ccc cga gac tca gga tgc     2352
 Val Asp Ser Gln Gly Leu Ser Gly Cys Ser Pro Arg Asp Ser Gly Cys
     770                 775                 780

 tac gaa agc agt gag aac ctg gaa aac ggt aat gtc agc atg agt cgc     2400
 Tyr Glu Ser Ser Glu Asn Leu Glu Asn Gly Asn Val Ser Met Ser Arg
 785                 790                 795                 800

 tgg gaa cct gct ttg aca agc aag act cgg aaa gct agc ctc cta tct     2448
 Trp Glu Pro Ala Leu Thr Ser Lys Thr Arg Lys Ala Ser Leu Leu Ser
                 805                 810                 815

 gcc aag tca tcc acc gag ccc agc ttg aag tct ttt agc aga aac cag     2496
 Ala Lys Ser Ser Thr Glu Pro Ser Leu Lys Ser Phe Ser Arg Asn Gln
             820                 825                 830

 ttg ggc aat tac cca aca ttg cct tta atg aaa tca ggg gat gca ctg     2544
 Leu Gly Asn Tyr Pro Thr Leu Pro Leu Met Lys Ser Gly Asp Ala Leu
         835                 840                 845

 aag cag gga cag gag gag ggc agg ctg ggt ggt ggc ctt gcc cca gac     2592
 Lys Gln Gly Gln Glu Glu Gly Arg Leu Gly Gly Gly Leu Ala Pro Asp
     850                 855                 860

 acg tcc aag agc tgt gac cca cct ggt gtg act ggt ttg aat aaa aac     2640
 Thr Ser Lys Ser Cys Asp Pro Pro Gly Val Thr Gly Leu Asn Lys Asn
 865                 870                 875                 880

 cga aga agc ctc cca gtt tcc atc tgc cgg agc tgt gag acc ctg gag     2688
 Arg Arg Ser Leu Pro Val Ser Ile Cys Arg Ser Cys Glu Thr Leu Glu
                 885                 890                 895

 ggc ccc cag act gtg gac act tgg ccc cga tcc cat tcc ctg gat gac     2736
 Gly Pro Gln Thr Val Asp Thr Trp Pro Arg Ser His Ser Leu Asp Asp
             900                 905                 910

 ctt caa gtg gag cct ggt gct gag caa gac gtg cct acc gag gtg aca     2784
 Leu Gln Val Glu Pro Gly Ala Glu Gln Asp Val Pro Thr Glu Val Thr
         915                 920                 925

 gaa ccg ccc cct cag att gta cct gaa gtg cca cag aag acg acc gcc     2832
 Glu Pro Pro Pro Gln Ile Val Pro Glu Val Pro Gln Lys Thr Thr Ala
     930                 935                 940

 tct tcc acg aag gcc cag ccc ctg gag caa gac tct gct gtc gac aat     2880
 Ser Ser Thr Lys Ala Gln Pro Leu Glu Gln Asp Ser Ala Val Asp Asn
 945                 950                 955                 960

 gca ttg cta ctg acc caa agc aag aga ttt tct gaa cct cag aaa ttg     2928
 Ala Leu Leu Leu Thr Gln Ser Lys Arg Phe Ser Glu Pro Gln Lys Leu
                 965                 970                 975

 aca act aag aaa ctg gag ggc tca atc gca gcc tct ggt cgc ggc ctg     2976
 Thr Thr Lys Lys Leu Glu Gly Ser Ile Ala Ala Ser Gly Arg Gly Leu
             980                 985                 990

 tca ccc cct cag tgt ttg ccc aga aac tat gat gct cag cct cct gga     3024
 Ser Pro Pro Gln Cys Leu Pro Arg Asn Tyr Asp Ala Gln Pro Pro Gly
         995                1000                1005

 gct aaa cac ggt tta gca agg acg cct ctg gag ggc cac aga aaa gga     3072
 Ala Lys His Gly Leu Ala Arg Thr Pro Leu Glu Gly His Arg Lys Gly
    1010                1015                1020

 cac gag ttt gaa gga aca cac cat ccc ctg ggc acc aaa gaa ggg gta     3120
 His Glu Phe Glu Gly Thr His His Pro Leu Gly Thr Lys Glu Gly Val
1025                1030                1035                1040

 gat gct gag cag aga atg cag ccc aaa att cca tca cag cct cca cct     3168
 Asp Ala Glu Gln Arg Met Gln Pro Lys Ile Pro Ser Gln Pro Pro Pro
                1045                1050                1055

 gtt cct gcc aaa aag agc aga gaa cgc ctt gct aac gga ctc cac cct     3216
 Val Pro Ala Lys Lys Ser Arg Glu Arg Leu Ala Asn Gly Leu His Pro
            1060                1065                1070

 gtt ccc atg ggc ccc agt ggg gcc ctc ccc agt ccc gat gcg cca tgc     3264
 Val Pro Met Gly Pro Ser Gly Ala Leu Pro Ser Pro Asp Ala Pro Cys
        1075                1080                1085

 ctg cca gtg aaa agg ggc agc ccc gcc agc ccc acc agc cct agc gac     3312
 Leu Pro Val Lys Arg Gly Ser Pro Ala Ser Pro Thr Ser Pro Ser Asp
    1090                1095                1100

 tgt ccc cca gca ctg gct ccc agg cct ctc tca ggg cag gcg cct ggc     3360
 Cys Pro Pro Ala Leu Ala Pro Arg Pro Leu Ser Gly Gln Ala Pro Gly
1105                1110                1115                1120

 agc cca cca agc aca agg ccg ccc ccc tgg ctc tca gag ctc ccc gag     3408
 Ser Pro Pro Ser Thr Arg Pro Pro Pro Trp Leu Ser Glu Leu Pro Glu
                1125                1130                1135

 aac aca agc ctc cag gag cac ggt gtg aag ctg ggc ccg gct ttg acc     3456
 Asn Thr Ser Leu Gln Glu His Gly Val Lys Leu Gly Pro Ala Leu Thr
            1140                1145                1150

 agg aag gtc tcc tgt gcc cgg gga gtg gat cta gaa acg ctc act gaa     3504
 Arg Lys Val Ser Cys Ala Arg Gly Val Asp Leu Glu Thr Leu Thr Glu
        1155                1160                1165

 aac aag ctg cac gct gaa ggc atc gat ctc acg gag gag ccg tat tct     3552
 Asn Lys Leu His Ala Glu Gly Ile Asp Leu Thr Glu Glu Pro Tyr Ser
    1170                1175                1180

 gat aag cat ggc cgc tgt ggg att cct gaa gcc ctg gtg cag aga tac     3600
 Asp Lys His Gly Arg Cys Gly Ile Pro Glu Ala Leu Val Gln Arg Tyr
1185                1190                1195                1200

 gca gag gac ttg gat cag ccc gag cgg gac gtc gcc gcc aac atg gac     3648
 Ala Glu Asp Leu Asp Gln Pro Glu Arg Asp Val Ala Ala Asn Met Asp
                1205                1210                1215

 cag atc cgg gtg aag cag ctt cgg aag cag cac cgc atg gcg att cca     3696
 Gln Ile Arg Val Lys Gln Leu Arg Lys Gln His Arg Met Ala Ile Pro
            1220                1225                1230

 agt ggt gga ctc acg gaa atc tgc cga aag ccc gtc tct cct ggg tgc     3744
 Ser Gly Gly Leu Thr Glu Ile Cys Arg Lys Pro Val Ser Pro Gly Cys
        1235                1240                1245

 att tcg tct gtg tca gat tgg ctc att tcc atc gaa ctt aga gtg tgt     3792
 Ile Ser Ser Val Ser Asp Trp Leu Ile Ser Ile Glu Leu Arg Val Cys
    1250                1255                1260

 gtg agt gtg tct gtg tct gtg aga gag aaa ggg agg agg gag aga gga     3840
 Val Ser Val Ser Val Ser Val Arg Glu Lys Gly Arg Arg Glu Arg Gly
1265                1270                1275                1280

 aga gaa gat gaa tgc tca ttc agg tct agg tct gga cca ctc atc aga     3888
 Arg Glu Asp Glu Cys Ser Phe Arg Ser Arg Ser Gly Pro Leu Ile Arg
                1285                1290                1295

 gaa cca tgg gaa cca tta ttt gga aat att cca att tcc aat aca gca     3936
 Glu Pro Trp Glu Pro Leu Phe Gly Asn Ile Pro Ile Ser Asn Thr Ala
            1300                1305                1310

 ccc ctc cca cat gac ctc aga gaa gaa tac tct gaa aag ggt att agc     3984
 Pro Leu Pro His Asp Leu Arg Glu Glu Tyr Ser Glu Lys Gly Ile Ser
        1315                1320                1325

 tgt cac ctt ctg cat act gta aca aaa aca ccg gaa gac cct aac caa     4032
 Cys His Leu Leu His Thr Val Thr Lys Thr Pro Glu Asp Pro Asn Gln
    1330                1335                1340

 act gag ttt gag ttc aat ctg gaa gga tcc cag ggt act tgt gtg acg     4080
 Thr Glu Phe Glu Phe Asn Leu Glu Gly Ser Gln Gly Thr Cys Val Thr
1345                1350                1355                1360

 gcc aca gca gtt aag act aat ctg gtt gga ttt tac cac cat ccc cat     4128
 Ala Thr Ala Val Lys Thr Asn Leu Val Gly Phe Tyr His His Pro His
                1365                1370                1375

 tca tcc tca atg gac ttt ccc caa aac ttg ggt aat gaa tat ggt tgg     4176
 Ser Ser Ser Met Asp Phe Pro Gln Asn Leu Gly Asn Glu Tyr Gly Trp
            1380                1385                1390

 aac cat aag aga gat gtg tac aaa tgg ctg tgg gaa cta gag gga gga     4224
 Asn His Lys Arg Asp Val Tyr Lys Trp Leu Trp Glu Leu Glu Gly Gly
        1395                1400                1405

 tgg att tgg cct ggg gac aga gag ggc cag agg agg tgg ttc tat gga     4272
 Trp Ile Trp Pro Gly Asp Arg Glu Gly Gln Arg Arg Trp Phe Tyr Gly
    1410                1415                1420

 taa                                                                 4275
 






      <210> 624
      <211> 684
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (1)..(684)

      <400> 624
  atg gtc tgg atg gcg gtg gcc ccc cca ttc ata tgt caa aac cta acc      48
  Met Val Trp Met Ala Val Ala Pro Pro Phe Ile Cys Gln Asn Leu Thr
    1               5                  10                  15

 ctc aat gca agg tcc cca ctc aac cgg tgc cca ccg ccc tgg cgc gcg       96
 Leu Asn Ala Arg Ser Pro Leu Asn Arg Cys Pro Pro Pro Trp Arg Ala
              20                  25                  30

 tcg ctc cgc gat tac cgg ccc gcc aaa cag tcc ccg caa agt cca ccc      144
 Ser Leu Arg Asp Tyr Arg Pro Ala Lys Gln Ser Pro Gln Ser Pro Pro
          35                  40                  45

 tcc ggg gct ccc ggt ccc tca ggt ccc gcg tgc ccg gcc ctg ggc atc      192
 Ser Gly Ala Pro Gly Pro Ser Gly Pro Ala Cys Pro Ala Leu Gly Ile
      50                  55                  60

 cgc agc gtc ccc gtg ctg cgg gcg acg cgg tcg atg gac atg ggc acc      240
 Arg Ser Val Pro Val Leu Arg Ala Thr Arg Ser Met Asp Met Gly Thr
  65                  70                  75                  80

 cag gga tcg ggg cgc aag cgg ctc ccc aac cgg gag cgg ctc acg gcg      288
 Gln Gly Ser Gly Arg Lys Arg Leu Pro Asn Arg Glu Arg Leu Thr Ala
                  85                  90                  95

 gag gac gac gcg ctc aac cag atc gcg cgg gag gat ttt gaa cgg cat      336
 Glu Asp Asp Ala Leu Asn Gln Ile Ala Arg Glu Asp Phe Glu Arg His
             100                 105                 110

 ccc tgg ctt ctg ccc agt agg cgc cag gag ctc ctc gct att ccc agc      384
 Pro Trp Leu Leu Pro Ser Arg Arg Gln Glu Leu Leu Ala Ile Pro Ser
         115                 120                 125

 tgt gac cac caa aca tgc ttc cag aca ttg tca aat ggc cca tgg gga      432
 Cys Asp His Gln Thr Cys Phe Gln Thr Leu Ser Asn Gly Pro Trp Gly
     130                 135                 140

 aca aga tac cca act gag gat ctc tgt gtc aga tta ctc aaa atc cag      480
 Thr Arg Tyr Pro Thr Glu Asp Leu Cys Val Arg Leu Leu Lys Ile Gln
 145                 150                 155                 160

 gtg tgg ctg cag gag aag gga cag gga aga ccc tca act tta gtc tca      528
 Val Trp Leu Gln Glu Lys Gly Gln Gly Arg Pro Ser Thr Leu Val Ser
                 165                 170                 175

 cct gtg gag gtg ggg ctg gag acc cag tcg tcc ttc acc ccc cag gac      576
 Pro Val Glu Val Gly Leu Glu Thr Gln Ser Ser Phe Thr Pro Gln Asp
             180                 185                 190

 cac ccc cca gat gag aag ggg gac tgg atg ttg gac aac aga aag gat      624
 His Pro Pro Asp Glu Lys Gly Asp Trp Met Leu Asp Asn Arg Lys Asp
         195                 200                 205

 cca tct ggg atc cac att gca ttt tgt cat cag ttc acc ttg gac tcc      672
 Pro Ser Gly Ile His Ile Ala Phe Cys His Gln Phe Thr Leu Asp Ser
     210                 215                 220

 tcc aat cca tga                                                      684
 Ser Asn Pro 
 225





      <210> 625
      <211> 981
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (1)..(981)

      <400> 625
  atg aca ggg gct gct tct cag ttc tct cag ttt aac att atg ctg act      48
  Met Thr Gly Ala Ala Ser Gln Phe Ser Gln Phe Asn Ile Met Leu Thr
    1               5                  10                  15

 tta cta atc aac ttg cag tct ttc cta cta gac ttt cag cag gat tta       96
 Leu Leu Ile Asn Leu Gln Ser Phe Leu Leu Asp Phe Gln Gln Asp Leu
              20                  25                  30

 gaa agg aaa tta aag ggg aat tct ggt tgg ccc agt ttg ggt tgc atg      144
 Glu Arg Lys Leu Lys Gly Asn Ser Gly Trp Pro Ser Leu Gly Cys Met
          35                  40                  45

 att att gct gaa cca atc act atg gtc aaa gtt tgg aga aat cag gaa      192
 Ile Ile Ala Glu Pro Ile Thr Met Val Lys Val Trp Arg Asn Gln Glu
      50                  55                  60

 ggg aag ctc ttt tct cga atc tcc atg tca ttt att tcc ctg att gac      240
 Gly Lys Leu Phe Ser Arg Ile Ser Met Ser Phe Ile Ser Leu Ile Asp
  65                  70                  75                  80

 cag act gta tat aaa gga tac ttg gaa aca ggc atc tta ttt ttt agc      288
 Gln Thr Val Tyr Lys Gly Tyr Leu Glu Thr Gly Ile Leu Phe Phe Ser
                  85                  90                  95

 ttc tct agc aga agc aca agt gag cgg acc tta tgg tcc aac cca ggg      336
 Phe Ser Ser Arg Ser Thr Ser Glu Arg Thr Leu Trp Ser Asn Pro Gly
             100                 105                 110

 ctg gcc act agt gtg aga agc cca gat gca caa ggc agg gtg tgt agc      384
 Leu Ala Thr Ser Val Arg Ser Pro Asp Ala Gln Gly Arg Val Cys Ser
         115                 120                 125

 ttg ggc agg ccc tca gct ttc att ggt gtg agt cag aag gtg ctt gag      432
 Leu Gly Arg Pro Ser Ala Phe Ile Gly Val Ser Gln Lys Val Leu Glu
     130                 135                 140

 aag gcc att cgg tct atg gcc tgt gcg ctt atg gac tat gct aca tac      480
 Lys Ala Ile Arg Ser Met Ala Cys Ala Leu Met Asp Tyr Ala Thr Tyr
 145                 150                 155                 160

 act gcc agt ggt atc cgt gaa caa gat aac aac act att act aac aac      528
 Thr Ala Ser Gly Ile Arg Glu Gln Asp Asn Asn Thr Ile Thr Asn Asn
                 165                 170                 175

 aat aaa atg aca tgg atg gag ctg gaa acc att atc ctc agc gaa ctg      576
 Asn Lys Met Thr Trp Met Glu Leu Glu Thr Ile Ile Leu Ser Glu Leu
             180                 185                 190

 aca cag gaa cag aga acc aaa cac cgt tat gtt ccc att tat aag tgg      624
 Thr Gln Glu Gln Arg Thr Lys His Arg Tyr Val Pro Ile Tyr Lys Trp
         195                 200                 205

 gag cta aac aat gag aac aca tgg aca cag gga ggg act cca aga cac      672
 Glu Leu Asn Asn Glu Asn Thr Trp Thr Gln Gly Gly Thr Pro Arg His
     210                 215                 220

 aaa gaa gtg tct gtc atc tat gca acc gat tat cag gat gaa gac tgt      720
 Lys Glu Val Ser Val Ile Tyr Ala Thr Asp Tyr Gln Asp Glu Asp Cys
 225                 230                 235                 240

 caa tca cgg tta ata aaa acc tca gaa cac gac aca gat ctc ttt tac      768
 Gln Ser Arg Leu Ile Lys Thr Ser Glu His Asp Thr Asp Leu Phe Tyr
                 245                 250                 255

 tat aga tgc att gct cag gtt ttc agt ttc ttg ttt tcc tgg tgg aat      816
 Tyr Arg Cys Ile Ala Gln Val Phe Ser Phe Leu Phe Ser Trp Trp Asn
             260                 265                 270

 ttg gaa ggg gtc atg aat cag gct gat gct cct cga ccc cta aac tgg      864
 Leu Glu Gly Val Met Asn Gln Ala Asp Ala Pro Arg Pro Leu Asn Trp
         275                 280                 285

 acc atc cgg aag ctg tgc cac gca gcc ttt ctt cca tct gtc aga ctt      912
 Thr Ile Arg Lys Leu Cys His Ala Ala Phe Leu Pro Ser Val Arg Leu
     290                 295                 300

 ctg aag ttt gcc aac tat gag atg atc ctt aag gtt ctt tcc acc ttt      960
 Leu Lys Phe Ala Asn Tyr Glu Met Ile Leu Lys Val Leu Ser Thr Phe
 305                 310                 315                 320

 aac att ctt gaa ttt act tag                                          981
 Asn Ile Leu Glu Phe Thr 
                 325





      <210> 626
      <211> 1104
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (1)..(1104)

      <400> 626
  atg gtg atc tcc cac atg gcc gtg tcc ggc gtc ggg atc tgg att gcc      48
  Met Val Ile Ser His Met Ala Val Ser Gly Val Gly Ile Trp Ile Ala
    1               5                  10                  15

 ttc acc tca ggg tcc acg ctc cgc ctt ttt cac acg gaa act ctc aag       96
 Phe Thr Ser Gly Ser Thr Leu Arg Leu Phe His Thr Glu Thr Leu Lys
              20                  25                  30

 cac ctg cag gac atc aac atc gcc acc cct gtt cac aac atg ctg cca      144
 His Leu Gln Asp Ile Asn Ile Ala Thr Pro Val His Asn Met Leu Pro
          35                  40                  45

 gga ggt gag gat gga gct gga gca gaa acc acc cca gtg gca gag cct      192
 Gly Gly Glu Asp Gly Ala Gly Ala Glu Thr Thr Pro Val Ala Glu Pro
      50                  55                  60

 act aag ctg gtg ctc ccg atg aaa gtc aac cca tat tct gtc atc gac      240
 Thr Lys Leu Val Leu Pro Met Lys Val Asn Pro Tyr Ser Val Ile Asp
  65                  70                  75                  80

 atc acg cca ttc cag gag gac cag ccg ccc acc ccc gtg ccc agc gct      288
 Ile Thr Pro Phe Gln Glu Asp Gln Pro Pro Thr Pro Val Pro Ser Ala
                  85                  90                  95

 gag gag gag aat gtg ggt ctc cat gtg ccc tgc ggg tac ttg gtg cct      336
 Glu Glu Glu Asn Val Gly Leu His Val Pro Cys Gly Tyr Leu Val Pro
             100                 105                 110

 gta ccc tgc ggc tat gcg gtg ccc tcc aac ctg ccc ctc ctg ctg ccc      384
 Val Pro Cys Gly Tyr Ala Val Pro Ser Asn Leu Pro Leu Leu Leu Pro
         115                 120                 125

 gcc tac tcc agc ccg gtc atc atc tgc gcc acg tcc ctg gac gaa gaa      432
 Ala Tyr Ser Ser Pro Val Ile Ile Cys Ala Thr Ser Leu Asp Glu Glu
     130                 135                 140

 gct gcc tac cca gag cgc cgg gcc ctt ccc gcc cac ctc ctg ggc tcc      480
 Ala Ala Tyr Pro Glu Arg Arg Ala Leu Pro Ala His Leu Leu Gly Ser
 145                 150                 155                 160

 aca ggg acc aac ggg cgg aga aca ctg ggc cat ggg cac cag cgg ctg      528
 Thr Gly Thr Asn Gly Arg Arg Thr Leu Gly His Gly His Gln Arg Leu
                 165                 170                 175

 tcg gtg acg agc ctg ctc gtc tgc cac gga ttg ctg atg gtc ggc acc      576
 Ser Val Thr Ser Leu Leu Val Cys His Gly Leu Leu Met Val Gly Thr
             180                 185                 190

 agc ctg gga gtc ctc gtg gcc ctg ccg gtc cca cgt ctg caa ggg att      624
 Ser Leu Gly Val Leu Val Ala Leu Pro Val Pro Arg Leu Gln Gly Ile
         195                 200                 205

 ccc aaa gtg acc ggg aaa atg cct gag atc ccc aaa ggc aag cac aac      672
 Pro Lys Val Thr Gly Lys Met Pro Glu Ile Pro Lys Gly Lys His Asn
     210                 215                 220

 gtg gcc aac ccc aaa cca gca gaa gtg aag ccc act gca ccc tgc gtt      720
 Val Ala Asn Pro Lys Pro Ala Glu Val Lys Pro Thr Ala Pro Cys Val
 225                 230                 235                 240

 gga gag gag ctg acg gac agt gga agc cga tac ctc att cga tca gat      768
 Gly Glu Glu Leu Thr Asp Ser Gly Ser Arg Tyr Leu Ile Arg Ser Asp
                 245                 250                 255

 gat atg ata gaa aca gtt tac aac gac aga gga gag att gtt aaa acc      816
 Asp Met Ile Glu Thr Val Tyr Asn Asp Arg Gly Glu Ile Val Lys Thr
             260                 265                 270

 aaa gaa cgc cga gtc ttc atg tta aat gat gtg tta atg tgt gcc acc      864
 Lys Glu Arg Arg Val Phe Met Leu Asn Asp Val Leu Met Cys Ala Thr
         275                 280                 285

 gtc agc tca cgc cgt gtg atg agc agc cag agg tac ttg ctg aag tgg      912
 Val Ser Ser Arg Arg Val Met Ser Ser Gln Arg Tyr Leu Leu Lys Trp
     290                 295                 300

 agc gtt cca ctg gga cat gtg gac gcc atc gag tat ggc agc agc gca      960
 Ser Val Pro Leu Gly His Val Asp Ala Ile Glu Tyr Gly Ser Ser Ala
 305                 310                 315                 320

 ggc acg ggc gag cac agc agg cac ctt gcc gtt cac ccg ccg gag agc     1008
 Gly Thr Gly Glu His Ser Arg His Leu Ala Val His Pro Pro Glu Ser
                 325                 330                 335

 ctg gcc gtg gtt gct aac gcg aaa cca atg aat cct gcc gcc tct gct     1056
 Leu Ala Val Val Ala Asn Ala Lys Pro Met Asn Pro Ala Ala Ser Ala
             340                 345                 350

 gcc acc ctg tgt gca ccc cca tgc tcc aaa aag gat gac ctc atc tag     1104
 Ala Thr Leu Cys Ala Pro Pro Cys Ser Lys Lys Asp Asp Leu Ile 
         355                 360                 365





      <210> 627
      <211> 813
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (1)..(813)

      <400> 627
  atg gag cct agg acc tct ctg att ggg cag tac ttg ttc cta atc ttt      48
  Met Glu Pro Arg Thr Ser Leu Ile Gly Gln Tyr Leu Phe Leu Ile Phe
    1               5                  10                  15

 atg ctg ggg cct ggg cag tta ccc tta ata gat gga aag gtg ctt agg       96
 Met Leu Gly Pro Gly Gln Leu Pro Leu Ile Asp Gly Lys Val Leu Arg
              20                  25                  30

 gaa act tcc att tta gaa gaa tac agt atc aat tgg act cag aag ctg      144
 Glu Thr Ser Ile Leu Glu Glu Tyr Ser Ile Asn Trp Thr Gln Lys Leu
          35                  40                  45

 gga gct gga att agt ggt cca gtt aga gtc tgt gta aag aaa tct act      192
 Gly Ala Gly Ile Ser Gly Pro Val Arg Val Cys Val Lys Lys Ser Thr
      50                  55                  60

 caa gaa cgg ttt gcg ctg aaa att ctt ctt gat cgt cca aaa gct aga      240
 Gln Glu Arg Phe Ala Leu Lys Ile Leu Leu Asp Arg Pro Lys Ala Arg
  65                  70                  75                  80

 aat gag ata gct ttg gct ctg cgg cac tgt cac ttg tta aac att gcg      288
 Asn Glu Ile Ala Leu Ala Leu Arg His Cys His Leu Leu Asn Ile Ala
                  85                  90                  95

 cac aga gac ctc aag cct gaa aat ctg ctt ttt aag gat aac tct ttg      336
 His Arg Asp Leu Lys Pro Glu Asn Leu Leu Phe Lys Asp Asn Ser Leu
             100                 105                 110

 gat gcc cca gtg aag ttg tgt gac ttt gga ttt gcc aag att gac caa      384
 Asp Ala Pro Val Lys Leu Cys Asp Phe Gly Phe Ala Lys Ile Asp Gln
         115                 120                 125

 ggt gac ttg atg aca ccc cag ttc acc cct tat tat gta gca ccc cag      432
 Gly Asp Leu Met Thr Pro Gln Phe Thr Pro Tyr Tyr Val Ala Pro Gln
     130                 135                 140

 tat ctt ccc cca gaa tgg tgt aag agc ttg caa atg gac cta agc tgt      480
 Tyr Leu Pro Pro Glu Trp Cys Lys Ser Leu Gln Met Asp Leu Ser Cys
 145                 150                 155                 160

 gac ttg tgg tcc cta ggg gtg att atc tat gtg atg ctg tgc gga tac      528
 Asp Leu Trp Ser Leu Gly Val Ile Ile Tyr Val Met Leu Cys Gly Tyr
                 165                 170                 175

 cct cct ttt tac tcc aaa cac cac agc cgg act atc cca aag gat atg      576
 Pro Pro Phe Tyr Ser Lys His His Ser Arg Thr Ile Pro Lys Asp Met
             180                 185                 190

 cga aga aag atc atg aca ggc agt ttt gag ttc cca gag gaa gag tgg      624
 Arg Arg Lys Ile Met Thr Gly Ser Phe Glu Phe Pro Glu Glu Glu Trp
         195                 200                 205

 agt cag atc tca gag atg gcc aaa gat gtt gtg agg aag ctc ctg aag      672
 Ser Gln Ile Ser Glu Met Ala Lys Asp Val Val Arg Lys Leu Leu Lys
     210                 215                 220

 gtc aaa ccg gag gag aga ctc acc atc gag gga gtg ctg gac cac ccc      720
 Val Lys Pro Glu Glu Arg Leu Thr Ile Glu Gly Val Leu Asp His Pro
 225                 230                 235                 240

 tgg ctc aat tcc acc gag gcc ctg gat aat gtg ctg cct tct gct cag      768
 Trp Leu Asn Ser Thr Glu Ala Leu Asp Asn Val Leu Pro Ser Ala Gln
                 245                 250                 255

 ctg atg atg gac aag gtt ttg aat gat gtt tac ttt gtt ggc tga          813
 Leu Met Met Asp Lys Val Leu Asn Asp Val Tyr Phe Val Gly 
             260                 265                 270





      <210> 628
      <211> 441
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (1)..(441)

      <400> 628
  atg gcc ggc ctc ccg cag gtg tct gcc cag ctc ctc tgc atc cca gcg      48
  Met Ala Gly Leu Pro Gln Val Ser Ala Gln Leu Leu Cys Ile Pro Ala
    1               5                  10                  15

 ccc ttg ctg gag gct agc caa gag gtg gtc aac aat acg tgg ata gaa       96
 Pro Leu Leu Glu Ala Ser Gln Glu Val Val Asn Asn Thr Trp Ile Glu
              20                  25                  30

 ggg agt gga gac aca ctt cac cag cag ctt ggc atc cag gag cag gga      144
 Gly Ser Gly Asp Thr Leu His Gln Gln Leu Gly Ile Gln Glu Gln Gly
          35                  40                  45

 aag aag ttc ttg gtc aca att gga atc att cac ctt caa gaa ata aga      192
 Lys Lys Phe Leu Val Thr Ile Gly Ile Ile His Leu Gln Glu Ile Arg
      50                  55                  60

 cag gca cag cgt gag ggg gtg ttt gct ttg ttc gcc tcc ccc ttg gat      240
 Gln Ala Gln Arg Glu Gly Val Phe Ala Leu Phe Ala Ser Pro Leu Asp
  65                  70                  75                  80

 ccc tcg ctc tcc act ggg ctg cct tca tca tca ttc atg ccc tgg cct      288
 Pro Ser Leu Ser Thr Gly Leu Pro Ser Ser Ser Phe Met Pro Trp Pro
                  85                  90                  95

 ggg ttt aaa agc gtg tgt ggg tca cga gca cct ctg aga aga gaa gac      336
 Gly Phe Lys Ser Val Cys Gly Ser Arg Ala Pro Leu Arg Arg Glu Asp
             100                 105                 110

 agg aca cgc aca caa agc aag ggt cag cca tgt gag gac agt gag aag      384
 Arg Thr Arg Thr Gln Ser Lys Gly Gln Pro Cys Glu Asp Ser Glu Lys
         115                 120                 125

 gcg gcc gtc gac acg cca agg aga gag gcc tgg gaa gaa acc aac ctt      432
 Ala Ala Val Asp Thr Pro Arg Arg Glu Ala Trp Glu Glu Thr Asn Leu
     130                 135                 140

 aca cct tga                                                          441
 Thr Pro 
 145





      <210> 629
      <211> 2739
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (1)..(2739)

      <400> 629
  atg ctg gtt act atc tgg gct atg gtg gcc aca gct gtc ttg ccc ctc      48
  Met Leu Val Thr Ile Trp Ala Met Val Ala Thr Ala Val Leu Pro Leu
    1               5                  10                  15

 ctc acg gcc gtg ctg ggt gtt acc gtg gtc acc cgc agg gac acg gag       96
 Leu Thr Ala Val Leu Gly Val Thr Val Val Thr Arg Arg Asp Thr Glu
              20                  25                  30

 ggg cca ggc aga gca gcc cta gtt cac ctc acc ggg agc ccc cgc cag      144
 Gly Pro Gly Arg Ala Ala Leu Val His Leu Thr Gly Ser Pro Arg Gln
          35                  40                  45

 aag gtg ggc acc tct ggg agg gag gga ctg cca ggc ctt ggg gct tcc      192
 Lys Val Gly Thr Ser Gly Arg Glu Gly Leu Pro Gly Leu Gly Ala Ser
      50                  55                  60

 tgt gct gag tca gag ctg gaa cgg gag acg cag gag ccc cgc agc cgc      240
 Cys Ala Glu Ser Glu Leu Glu Arg Glu Thr Gln Glu Pro Arg Ser Arg
  65                  70                  75                  80

 ggg agg gcc tcg gct tca cag gat ggg gct gcc agt gtc ctg ggc ccc      288
 Gly Arg Ala Ser Ala Ser Gln Asp Gly Ala Ala Ser Val Leu Gly Pro
                  85                  90                  95

 tcc tgc cct ctg ggt tct agg gtg ctg cgc cct gct cct ctc gct gtg      336
 Ser Cys Pro Leu Gly Ser Arg Val Leu Arg Pro Ala Pro Leu Ala Val
             100                 105                 110

 ggc gct gtg cac agc ctg ccg cag gcc cga gga cgc tgt agc ccc cag      384
 Gly Ala Val His Ser Leu Pro Gln Ala Arg Gly Arg Cys Ser Pro Gln
         115                 120                 125

 gaa gag ggc gcg gag gca gcg ggc gag gct gca ggg cag tgc gac ggc      432
 Glu Glu Gly Ala Glu Ala Ala Gly Glu Ala Ala Gly Gln Cys Asp Gly
     130                 135                 140

 ggc gga agc ggt gag tgc cag gct gtc ccg ggg acc agg tcc cta ctg      480
 Gly Gly Ser Gly Glu Cys Gln Ala Val Pro Gly Thr Arg Ser Leu Leu
 145                 150                 155                 160

 agg cgg acc cac ctc tgc tcc ctc agc aag tcg gac acc aga ctg cac      528
 Arg Arg Thr His Leu Cys Ser Leu Ser Lys Ser Asp Thr Arg Leu His
                 165                 170                 175

 gag ctg cac cgg ggc ccg cgc agc agc agg gcc ctg cgg cct gcc agc      576
 Glu Leu His Arg Gly Pro Arg Ser Ser Arg Ala Leu Arg Pro Ala Ser
             180                 185                 190

 atg gat ctc ctg cgc cca cac tgg ctg gag gtg tcc agg gac atc acc      624
 Met Asp Leu Leu Arg Pro His Trp Leu Glu Val Ser Arg Asp Ile Thr
         195                 200                 205

 gga ccg cag gca gcc ccc tct gcc ttc cca cac cag gag ctg ccc cgg      672
 Gly Pro Gln Ala Ala Pro Ser Ala Phe Pro His Gln Glu Leu Pro Arg
     210                 215                 220

 gct ctg ccg gca gct gca gcc acc gca ggg tgc gct ggc ctc gag gcc      720
 Ala Leu Pro Ala Ala Ala Ala Thr Ala Gly Cys Ala Gly Leu Glu Ala
 225                 230                 235                 240

 acc tat tcc aac gtg ggg ctg gcg gcc ctt ccc ggg gtc agc ctg gcg      768
 Thr Tyr Ser Asn Val Gly Leu Ala Ala Leu Pro Gly Val Ser Leu Ala
                 245                 250                 255

 gcc agc cct gtg gtg gcc gag tat gcc cgc gtc cag aag cgc aaa ggg      816
 Ala Ser Pro Val Val Ala Glu Tyr Ala Arg Val Gln Lys Arg Lys Gly
             260                 265                 270

 acc cat cgc agt ccc caa gag cca cag cag ggg aag act gag gtg acc      864
 Thr His Arg Ser Pro Gln Glu Pro Gln Gln Gly Lys Thr Glu Val Thr
         275                 280                 285

 ccg gcc gct cag gtg gac gtc ctg tac tcc agg gtc tgc aag cct aaa      912
 Pro Ala Ala Gln Val Asp Val Leu Tyr Ser Arg Val Cys Lys Pro Lys
     290                 295                 300

 agg agg gac cca gga ccc acc aca gac ccg ctg gac ccc aag ggc cag      960
 Arg Arg Asp Pro Gly Pro Thr Thr Asp Pro Leu Asp Pro Lys Gly Gln
 305                 310                 315                 320

 gga gcg att ctg gcc ctg gcg ggt gac ctg gcc tac cag acc ctc ccg     1008
 Gly Ala Ile Leu Ala Leu Ala Gly Asp Leu Ala Tyr Gln Thr Leu Pro
                 325                 330                 335

 ctc agg gcc ctg gat gtg gac agc ggc ccc ctg gaa aac gtg tat gag     1056
 Leu Arg Ala Leu Asp Val Asp Ser Gly Pro Leu Glu Asn Val Tyr Glu
             340                 345                 350

 agc atc cgg gag ctg ggg gac cct gct ggc agg agc agc aca gaa ggc     1104
 Ser Ile Arg Glu Leu Gly Asp Pro Ala Gly Arg Ser Ser Thr Glu Gly
         355                 360                 365

 ccg cgt cta aat aaa gcg cca gcg cag gat gaa agc ggc cag cct cgc     1152
 Pro Arg Leu Asn Lys Ala Pro Ala Gln Asp Glu Ser Gly Gln Pro Arg
     370                 375                 380

 agc ctg ctc ttc ttg aaa gct ggg cgg gtt ggg gcg ggg ggc ttc tct     1200
 Ser Leu Leu Phe Leu Lys Ala Gly Arg Val Gly Ala Gly Gly Phe Ser
 385                 390                 395                 400

 gga agg ctt gga gct gtc ccc tct ggc ctt ggg gga ctg gct gcc ccc     1248
 Gly Arg Leu Gly Ala Val Pro Ser Gly Leu Gly Gly Leu Ala Ala Pro
                 405                 410                 415

 ggg gcg ccc ggg cct agc cga ggc ggt gct cct gcc ggc cag act ctc     1296
 Gly Ala Pro Gly Pro Ser Arg Gly Gly Ala Pro Ala Gly Gln Thr Leu
             420                 425                 430

 gcc tcg gcg ccc ggc cgg ccg gcc atg gag cgc ccc ccg ccc cgc gcc     1344
 Ala Ser Ala Pro Gly Arg Pro Ala Met Glu Arg Pro Pro Pro Arg Ala
         435                 440                 445

 gcc ggc cgg gac ccc agt gcg ctg cgg gcc gag gcg ccg tgg ctg cgc     1392
 Ala Gly Arg Asp Pro Ser Ala Leu Arg Ala Glu Ala Pro Trp Leu Arg
     450                 455                 460

 gcg gag ggt ccg ggg ccg cgc gcc gcg ccc gtg acg gtg ccc acg ccg     1440
 Ala Glu Gly Pro Gly Pro Arg Ala Ala Pro Val Thr Val Pro Thr Pro
 465                 470                 475                 480

 ccg cag ggc tct tcc gtg ggc ggc ggc ttc gcg ggc ttg gag ttc gcg     1488
 Pro Gln Gly Ser Ser Val Gly Gly Gly Phe Ala Gly Leu Glu Phe Ala
                 485                 490                 495

 cgg ccg cag gag tcg gag ccg cgg gcc tcg gac ctg ggg gcc ccc cgg     1536
 Arg Pro Gln Glu Ser Glu Pro Arg Ala Ser Asp Leu Gly Ala Pro Arg
             500                 505                 510

 acg tgg acg ggg gcg gcg gcg ggg ccc cgg act ccg tcg gcg cac atc     1584
 Thr Trp Thr Gly Ala Ala Ala Gly Pro Arg Thr Pro Ser Ala His Ile
         515                 520                 525

 ccc gtc cca gcg cag aga gcc acc cca gga aaa gcc cgg ctg gac gag     1632
 Pro Val Pro Ala Gln Arg Ala Thr Pro Gly Lys Ala Arg Leu Asp Glu
     530                 535                 540

 gtc atg gct gcc gct gcc ctt aca agc ctg tcc acc agc cct ctc ctt     1680
 Val Met Ala Ala Ala Ala Leu Thr Ser Leu Ser Thr Ser Pro Leu Leu
 545                 550                 555                 560

 ctg ggg gcc ccg gtt gca gcc ttc agc cca gtg ccc cct act gag gcc     1728
 Leu Gly Ala Pro Val Ala Ala Phe Ser Pro Val Pro Pro Thr Glu Ala
                 565                 570                 575

 aaa gcg gca gga ccc agg cct tct ggc ctc cct gac ctg ctc acc tcc     1776
 Lys Ala Ala Gly Pro Arg Pro Ser Gly Leu Pro Asp Leu Leu Thr Ser
             580                 585                 590

 acg cgg ctg gcc aca cac gtc tgc caa ccc ttt cct gtg ccg ggg ggg     1824
 Thr Arg Leu Ala Thr His Val Cys Gln Pro Phe Pro Val Pro Gly Gly
         595                 600                 605

 ttt ctc ccc aag ccc tgg ggc cag ctc ctc caa gac gct ctg ccc acc     1872
 Phe Leu Pro Lys Pro Trp Gly Gln Leu Leu Gln Asp Ala Leu Pro Thr
     610                 615                 620

 agt ctc acc gga ctt ggt gaa cag ggg cag ctc agg att agg gac tcc     1920
 Ser Leu Thr Gly Leu Gly Glu Gln Gly Gln Leu Arg Ile Arg Asp Ser
 625                 630                 635                 640

 ctg gac cca ccc gaa gtt cta agg cgg ggg gcc cgt gtc ccc aca gag     1968
 Leu Asp Pro Pro Glu Val Leu Arg Arg Gly Ala Arg Val Pro Thr Glu
                 645                 650                 655

 cct ggc ctg gag ccc tgg aag gag gcc ctg gtg cgg ccc cca ggc agc     2016
 Pro Gly Leu Glu Pro Trp Lys Glu Ala Leu Val Arg Pro Pro Gly Ser
             660                 665                 670

 tac agc agc agc agc aac agt gga gac tgg gga tgg gac ctg gcc agt     2064
 Tyr Ser Ser Ser Ser Asn Ser Gly Asp Trp Gly Trp Asp Leu Ala Ser
         675                 680                 685

 gac cag tcc tct ccg tcc acc ccg tca ccc cca ctg ccc ccc gag gca     2112
 Asp Gln Ser Ser Pro Ser Thr Pro Ser Pro Pro Leu Pro Pro Glu Ala
     690                 695                 700

 gcc cac ttt ctg ttt ggg gag ccc acc ctg aga aaa agg aag agc ccg     2160
 Ala His Phe Leu Phe Gly Glu Pro Thr Leu Arg Lys Arg Lys Ser Pro
 705                 710                 715                 720

 gcc cag gtc atg ttc cag tgt ctg tgg aag agc tgc ggg aag gtg ctg     2208
 Ala Gln Val Met Phe Gln Cys Leu Trp Lys Ser Cys Gly Lys Val Leu
                 725                 730                 735

 agc acg gcg tcg gcg atg cag aga cac atc cgc ctg gtg cac ctg ggg     2256
 Ser Thr Ala Ser Ala Met Gln Arg His Ile Arg Leu Val His Leu Gly
             740                 745                 750

 agg cag gca gag cct gag cag agt gat ggt gag gag gac ttc tac tac     2304
 Arg Gln Ala Glu Pro Glu Gln Ser Asp Gly Glu Glu Asp Phe Tyr Tyr
         755                 760                 765

 aca gag ctg gat gtt ggt gtg gac acg ctg acc gac ggg ctg tcc agc     2352
 Thr Glu Leu Asp Val Gly Val Asp Thr Leu Thr Asp Gly Leu Ser Ser
     770                 775                 780

 ctg act cca gtg tcc ccc acg gcc tcc atg ccg cct gcc ttc ccc cgc     2400
 Leu Thr Pro Val Ser Pro Thr Ala Ser Met Pro Pro Ala Phe Pro Arg
 785                 790                 795                 800

 ctg gag ctg cca gag ctg ctg gag ccc cca gcc ctg cct agt ccc ctg     2448
 Leu Glu Leu Pro Glu Leu Leu Glu Pro Pro Ala Leu Pro Ser Pro Leu
                 805                 810                 815

 cgg ccg cct gcc ccg ccc ctg ccc ccg ccc cct gtc ctg agc acc gtt     2496
 Arg Pro Pro Ala Pro Pro Leu Pro Pro Pro Pro Val Leu Ser Thr Val
             820                 825                 830

 gct aac ccc cag tcc tgt cac agt gac cgt gtc tac cag ggc tgc ctg     2544
 Ala Asn Pro Gln Ser Cys His Ser Asp Arg Val Tyr Gln Gly Cys Leu
         835                 840                 845

 acg ccc gcc cgc ctg gag ccg cag ccc acg gag gtc gga gcc tgc cca     2592
 Thr Pro Ala Arg Leu Glu Pro Gln Pro Thr Glu Val Gly Ala Cys Pro
     850                 855                 860

 ccc gcc ttg tcc tcc agg atc gga gtc acc ctg agg aag ccc cgc ggc     2640
 Pro Ala Leu Ser Ser Arg Ile Gly Val Thr Leu Arg Lys Pro Arg Gly
 865                 870                 875                 880

 gac gcg aag aag tgc cgg aag gtg tat ggc atg gag cgc cgg gac ctc     2688
 Asp Ala Lys Lys Cys Arg Lys Val Tyr Gly Met Glu Arg Arg Asp Leu
                 885                 890                 895

 tgg tgc aca gcc tgc cgc tgg aag aaa gcc tgc cag cgg ttc ctg gac     2736
 Trp Cys Thr Ala Cys Arg Trp Lys Lys Ala Cys Gln Arg Phe Leu Asp
             900                 905                 910

 taa                                                                 2739
 






      <210> 630
      <211> 2529
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (1)..(2529)

      <400> 630
  atg ttg act gtc atg tgc agg gcc ctc ctg gta ttc ctg gga gaa atg      48
  Met Leu Thr Val Met Cys Arg Ala Leu Leu Val Phe Leu Gly Glu Met
    1               5                  10                  15

 gtg acc ctg gta ttc cag gac aac cag ggt ccc ctg gtt ctc ctg gcc       96
 Val Thr Leu Val Phe Gln Asp Asn Gln Gly Pro Leu Val Leu Leu Ala
              20                  25                  30

 ccc ctg gaa tct gtg aat cat gcc cta ctg gtc ctc agg att att tct      144
 Pro Leu Glu Ser Val Asn His Ala Leu Leu Val Leu Arg Ile Ile Ser
          35                  40                  45

 gcc tat gaa act gct ctt gct aat act tca gag cac acc ttg ctt ctc      192
 Ala Tyr Glu Thr Ala Leu Ala Asn Thr Ser Glu His Thr Leu Leu Leu
      50                  55                  60

 ctg aag cat ggc agc caa ata aat ctg cag aac tat tct ccc cag tat      240
 Leu Lys His Gly Ser Gln Ile Asn Leu Gln Asn Tyr Ser Pro Gln Tyr
  65                  70                  75                  80

 gat tca tat gat gtc aag tct gga gta gca gta gga gga ctc gca ggc      288
 Asp Ser Tyr Asp Val Lys Ser Gly Val Ala Val Gly Gly Leu Ala Gly
                  85                  90                  95

 tat cct gga cca gct gtc cat ctg gtc ctg ctg gaa aag atg gag aat      336
 Tyr Pro Gly Pro Ala Val His Leu Val Leu Leu Glu Lys Met Glu Asn
             100                 105                 110

 cag gta gac ccg gac gac ctg gag agc gag gat tgc ctg gac ctc cag      384
 Gln Val Asp Pro Asp Asp Leu Glu Ser Glu Asp Cys Leu Asp Leu Gln
         115                 120                 125

 gtg ctc ggg gta atg acg gtg ctc gag gca gtg atg gtc aac cag gtg      432
 Val Leu Gly Val Met Thr Val Leu Glu Ala Val Met Val Asn Gln Val
     130                 135                 140

 aag ttg gac ctg cag ggt ctc ctg gtt caa atg gtg ccc ctg gac aaa      480
 Lys Leu Asp Leu Gln Gly Leu Leu Val Gln Met Val Pro Leu Asp Lys
 145                 150                 155                 160

 gag gag aac ctg gac ctc agg gac acg ctg gtg ctc aag gtc ctc ctg      528
 Glu Glu Asn Leu Asp Leu Arg Asp Thr Leu Val Leu Lys Val Leu Leu
                 165                 170                 175

 gtg agc ctg gta aga atg gtg cca aag gag agc ccg gac cac gtg gtg      576
 Val Ser Leu Val Arg Met Val Pro Lys Glu Ser Pro Asp His Val Val
             180                 185                 190

 aac gcg gtg agg ctg gta ttc cag gtg ttc cag gag cta aag gcg aag      624
 Asn Ala Val Arg Leu Val Phe Gln Val Phe Gln Glu Leu Lys Ala Lys
         195                 200                 205

 atg gca agg atg gat cac ctg gag aac ctg gtg caa atg ggc ttc cag      672
 Met Ala Arg Met Asp His Leu Glu Asn Leu Val Gln Met Gly Phe Gln
     210                 215                 220

 gag ctg cag gag aaa ggg gtg ctc ctg gta aga atg gag aac gag gtg      720
 Glu Leu Gln Glu Lys Gly Val Leu Leu Val Arg Met Glu Asn Glu Val
 225                 230                 235                 240

 gcc ctg gag gac ctg gcc ctc agg ggc ctg gtg gtg aca aag gag aca      768
 Ala Leu Glu Asp Leu Ala Leu Arg Gly Leu Val Val Thr Lys Glu Thr
                 245                 250                 255

 cag gac ccc ctg gtc cac aag gat tac aag gtg atg ctg gtg ccc ctg      816
 Gln Asp Pro Leu Val His Lys Asp Tyr Lys Val Met Leu Val Pro Leu
             260                 265                 270

 gtg aac gtg gac ctc ctg gat tgg cag ggg ccc cag gac tta gag gtg      864
 Val Asn Val Asp Leu Leu Asp Trp Gln Gly Pro Gln Asp Leu Glu Val
         275                 280                 285

 gag ctg gtc ccc ctg gtc ccg aag gag gaa agg gtg aac cag gcg gtc      912
 Glu Leu Val Pro Leu Val Pro Lys Glu Glu Arg Val Asn Gln Ala Val
     290                 295                 300

 cag gtg ctg atg gtg tcc cag gga aag atg gcc caa ggg gtg aag gtg      960
 Gln Val Leu Met Val Ser Gln Gly Lys Met Ala Gln Gly Val Lys Val
 305                 310                 315                 320

 gtg ccc cgg act tcc agg gtg aga gag gtg aaa ctg gcc ctc cag gac     1008
 Val Pro Arg Thr Ser Arg Val Arg Glu Val Lys Leu Ala Leu Gln Asp
                 325                 330                 335

 ctg ctg gtt tcc ctg gtg ctc ctg gac aga atg gtg aac ctg gtg gta     1056
 Leu Leu Val Ser Leu Val Leu Leu Asp Arg Met Val Asn Leu Val Val
             340                 345                 350

 aag gag aaa gag ggg ctc cgg gtg aga aag gtg aag gag gcc ctc ctg     1104
 Lys Glu Lys Glu Gly Leu Arg Val Arg Lys Val Lys Glu Ala Leu Leu
         355                 360                 365

 gag ttg cag gac ccc ctg gag gtt ctg gac ctg ctg gtc ctc ctg gtc     1152
 Glu Leu Gln Asp Pro Leu Glu Val Leu Asp Leu Leu Val Leu Leu Val
     370                 375                 380

 ccc aag gtg tca aag gtg aac gtg gca gtc ctg gtg gac ctg gtg aaa     1200
 Pro Lys Val Ser Lys Val Asn Val Ala Val Leu Val Asp Leu Val Lys
 385                 390                 395                 400

 gtg gga aac cag gag cta acg gtc tca gtg gag aac gtg gtc ccc ctg     1248
 Val Gly Asn Gln Glu Leu Thr Val Ser Val Glu Asn Val Val Pro Leu
                 405                 410                 415

 gac ccc agg gtc ttc ctg gtc tgg ctg gta cag ctg gtg aac ctg gaa     1296
 Asp Pro Arg Val Phe Leu Val Trp Leu Val Gln Leu Val Asn Leu Glu
             420                 425                 430

 gag atg gtg atc gtg gtg aaa atg gct ctc ctg gtg ccc ctg gcg ctc     1344
 Glu Met Val Ile Val Val Lys Met Ala Leu Leu Val Pro Leu Ala Leu
         435                 440                 445

 ctg gtc atc cag gcc cac ctg gtc ctg tcg gtc cag ctg gaa aga gtg     1392
 Leu Val Ile Gln Ala His Leu Val Leu Ser Val Gln Leu Glu Arg Val
     450                 455                 460

 gtg aca gag gag aaa gtg gtc ctc aag gcc cac gtg gtg aca aag gtg     1440
 Val Thr Glu Glu Lys Val Val Leu Lys Ala His Val Val Thr Lys Val
 465                 470                 475                 480

 aaa cag gtg aac gtg gag ctg ctg gca tca aag gac atc gag gat tcc     1488
 Lys Gln Val Asn Val Glu Leu Leu Ala Ser Lys Asp Ile Glu Asp Ser
                 485                 490                 495

 ctg gta atc cag gtg ccc cag gtt ctc cag gcc ctg ctg gtc agc agg     1536
 Leu Val Ile Gln Val Pro Gln Val Leu Gln Ala Leu Leu Val Ser Arg
             500                 505                 510

 gtg caa tcg gca gtc cag gac ctg cag gcc cca gag gac ctg ttg gac     1584
 Val Gln Ser Ala Val Gln Asp Leu Gln Ala Pro Glu Asp Leu Leu Asp
         515                 520                 525

 cca gtg gac ctc ctg gca aag atg gaa cca gtg gac atc cag gtc cca     1632
 Pro Val Asp Leu Leu Ala Lys Met Glu Pro Val Asp Ile Gln Val Pro
     530                 535                 540

 ttg gac cac cag ggc ctc gag ggc tcc cca ggc cac cca ggg caa cca     1680
 Leu Asp His Gln Gly Leu Glu Gly Ser Pro Gly His Pro Gly Gln Pro
 545                 550                 555                 560

 ggc cct cct gga cct cct ggt gcc cct ggt cct tgc tgt ggt ggt gtt     1728
 Gly Pro Pro Gly Pro Pro Gly Ala Pro Gly Pro Cys Cys Gly Gly Val
                 565                 570                 575

 gga gcc gct gcc att gct ggg att gga ggt gaa aaa gct ggc ggt ttt     1776
 Gly Ala Ala Ala Ile Ala Gly Ile Gly Gly Glu Lys Ala Gly Gly Phe
             580                 585                 590

 gcc ccg tat tat gga gat gaa cca atg gat ttc aaa atc aac acc gat     1824
 Ala Pro Tyr Tyr Gly Asp Glu Pro Met Asp Phe Lys Ile Asn Thr Asp
         595                 600                 605

 gag att atg act tca ctc aag tct gtt aat gga caa ata gaa agc ctc     1872
 Glu Ile Met Thr Ser Leu Lys Ser Val Asn Gly Gln Ile Glu Ser Leu
     610                 615                 620

 att agt cct gat ggt tct cgt aaa aac ccc gct aga aac tgc aga gac     1920
 Ile Ser Pro Asp Gly Ser Arg Lys Asn Pro Ala Arg Asn Cys Arg Asp
 625                 630                 635                 640

 ctg aaa ttc tgc cat cct gaa ctc aag agt gga gaa tac tgg gtt gac     1968
 Leu Lys Phe Cys His Pro Glu Leu Lys Ser Gly Glu Tyr Trp Val Asp
                 645                 650                 655

 cct aac caa gga tgc aaa ttg gat gct atc aag gta ttc tgt aat atg     2016
 Pro Asn Gln Gly Cys Lys Leu Asp Ala Ile Lys Val Phe Cys Asn Met
             660                 665                 670

 gaa act ggg gaa aca tgc ata agt gcc aat cct ttg aat gtt cca cgg     2064
 Glu Thr Gly Glu Thr Cys Ile Ser Ala Asn Pro Leu Asn Val Pro Arg
         675                 680                 685

 aaa cac tgg tgg aca gat tct agt gct gag aag aaa cac gtt tgg ttt     2112
 Lys His Trp Trp Thr Asp Ser Ser Ala Glu Lys Lys His Val Trp Phe
     690                 695                 700

 gga gag tcc atg gat ggt ggt ttt cag ttt agc tac ggc aat cct gaa     2160
 Gly Glu Ser Met Asp Gly Gly Phe Gln Phe Ser Tyr Gly Asn Pro Glu
 705                 710                 715                 720

 ctt cct gaa gat gtc ctt gat gtg cat ctg gca ttc ctt cga ctt ctc     2208
 Leu Pro Glu Asp Val Leu Asp Val His Leu Ala Phe Leu Arg Leu Leu
                 725                 730                 735

 tcc agc cga gct tcc cag aac atc aca tat cac tgc aaa aat agc att     2256
 Ser Ser Arg Ala Ser Gln Asn Ile Thr Tyr His Cys Lys Asn Ser Ile
             740                 745                 750

 gca tac atg gat cag gcc agt gga aat gta aag aag gcc ctg aag ctg     2304
 Ala Tyr Met Asp Gln Ala Ser Gly Asn Val Lys Lys Ala Leu Lys Leu
         755                 760                 765

 atg ggg tca aat gaa ggt gaa ttc aag gct gaa gga aat agc aaa ttc     2352
 Met Gly Ser Asn Glu Gly Glu Phe Lys Ala Glu Gly Asn Ser Lys Phe
     770                 775                 780

 acc tac aca gtt ctg gag gat ggt tgc acg aaa cac act ggg gaa tgg     2400
 Thr Tyr Thr Val Leu Glu Asp Gly Cys Thr Lys His Thr Gly Glu Trp
 785                 790                 795                 800

 agc aaa aca gtc ttt gaa tat cga aca cgc aag gct gtg aga cta cct     2448
 Ser Lys Thr Val Phe Glu Tyr Arg Thr Arg Lys Ala Val Arg Leu Pro
                 805                 810                 815

 att gta gat att gca ccc tat gac att ggt ggt cct gat caa gaa ttt     2496
 Ile Val Asp Ile Ala Pro Tyr Asp Ile Gly Gly Pro Asp Gln Glu Phe
             820                 825                 830

 ggt gtg gac gtt ggc cct gtt tgc ttt tta taa                         2529
 Gly Val Asp Val Gly Pro Val Cys Phe Leu 
         835                 840





      <210> 631
      <211> 4005
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (1)..(4005)

      <400> 631
  atg gtg ccc agc tct ccg cgc gcg ctc ttc ctt ctg ctc ctg atc ctc      48
  Met Val Pro Ser Ser Pro Arg Ala Leu Phe Leu Leu Leu Leu Ile Leu
    1               5                  10                  15

 gcc tgc ccc gag ccg cgg gct tcc cag cgg tgg gca gcg gag agc ctg       96
 Ala Cys Pro Glu Pro Arg Ala Ser Gln Arg Trp Ala Ala Glu Ser Leu
              20                  25                  30

 cac acg gag tgc ctg gtg cgc ctc agg ctc cct gca ggg cat ctt cca      144
 His Thr Glu Cys Leu Val Arg Leu Arg Leu Pro Ala Gly His Leu Pro
          35                  40                  45

 gtc act tca ttc ccg gag cta ccc tgt gaa gtg ggg act gtt acc ccc      192
 Val Thr Ser Phe Pro Glu Leu Pro Cys Glu Val Gly Thr Val Thr Pro
      50                  55                  60

 att ttg cag atg atg aaa aaa tat agc tct cct acg cgt gat att aac      240
 Ile Leu Gln Met Met Lys Lys Tyr Ser Ser Pro Thr Arg Asp Ile Asn
  65                  70                  75                  80

 atc gct ctg gaa cag ttg ttg gcc gaa gat tca att gat gca tcc gat      288
 Ile Ala Leu Glu Gln Leu Leu Ala Glu Asp Ser Ile Asp Ala Ser Asp
                  85                  90                  95

 ttt tcc caa ata gac gat ttt aat gat tca gac aat tct gat cag cct      336
 Phe Ser Gln Ile Asp Asp Phe Asn Asp Ser Asp Asn Ser Asp Gln Pro
             100                 105                 110

 cca ctt ctc cct ggc aca ttc aag aat gag atc tac atc ctg tca agg      384
 Pro Leu Leu Pro Gly Thr Phe Lys Asn Glu Ile Tyr Ile Leu Ser Arg
         115                 120                 125

 gca gcc ctg att gca gag gag aat gga agt ccc ctt gct ccc ttg ggg      432
 Ala Ala Leu Ile Ala Glu Glu Asn Gly Ser Pro Leu Ala Pro Leu Gly
     130                 135                 140

 tca ttt ctg gcc ctg ggg gca ttg ggc act cac caa gca gga aga gaa      480
 Ser Phe Leu Ala Leu Gly Ala Leu Gly Thr His Gln Ala Gly Arg Glu
 145                 150                 155                 160

 aaa cca gac aaa tta gaa aag tat cag agg gcc aac gat tgc cta agc      528
 Lys Pro Asp Lys Leu Glu Lys Tyr Gln Arg Ala Asn Asp Cys Leu Ser
                 165                 170                 175

 ggg gtg ctg cat tgg agg gtg gcc acg agc tac tcc agg tta agc aag      576
 Gly Val Leu His Trp Arg Val Ala Thr Ser Tyr Ser Arg Leu Ser Lys
             180                 185                 190

 cag gta ggg aac tct cta agg agg gga ctt cta agt cga agt gga aag      624
 Gln Val Gly Asn Ser Leu Arg Arg Gly Leu Leu Ser Arg Ser Gly Lys
         195                 200                 205

 aca act cta gag gac tcc act cta gag gac ctg ggg gca gat tct cca      672
 Thr Thr Leu Glu Asp Ser Thr Leu Glu Asp Leu Gly Ala Asp Ser Pro
     210                 215                 220

 ggc aga ggg ccc agc cgg tgc aaa ggc ccc aag gtg ggt gta gcc tgg      720
 Gly Arg Gly Pro Ser Arg Cys Lys Gly Pro Lys Val Gly Val Ala Trp
 225                 230                 235                 240

 gga ggt tca tgg agg gga ttg cag ctg ctg gat gcc atg tgt gtg gac      768
 Gly Gly Ser Trp Arg Gly Leu Gln Leu Leu Asp Ala Met Cys Val Asp
                 245                 250                 255

 ccc aag ctc ctt gct tgg ctt ggg cat tgg gga cct cag aga ctt gct      816
 Pro Lys Leu Leu Ala Trp Leu Gly His Trp Gly Pro Gln Arg Leu Ala
             260                 265                 270

 gaa gat aat acc gag gct gtg aaa ggc aca acc caa tcc aca ggt gca      864
 Glu Asp Asn Thr Glu Ala Val Lys Gly Thr Thr Gln Ser Thr Gly Ala
         275                 280                 285

 gat ggc ctc tgg aca aag aac cat cca tgc cac ctc tac tcc agc ttg      912
 Asp Gly Leu Trp Thr Lys Asn His Pro Cys His Leu Tyr Ser Ser Leu
     290                 295                 300

 gaa aaa cct gga tgg ggt gac atc tgt tgt tcc ttc tct aac tgg ttc      960
 Glu Lys Pro Gly Trp Gly Asp Ile Cys Cys Ser Phe Ser Asn Trp Phe
 305                 310                 315                 320

 tct gca aac att gcc att ggt gtc aag tta gat gaa gta ctc acc cct     1008
 Ser Ala Asn Ile Ala Ile Gly Val Lys Leu Asp Glu Val Leu Thr Pro
                 325                 330                 335

 tta aag agt ttc ata aca gaa acg aac tgt ctc agc aaa cag cag ctc     1056
 Leu Lys Ser Phe Ile Thr Glu Thr Asn Cys Leu Ser Lys Gln Gln Leu
             340                 345                 350

 ctc tcg gcc atc cgc cag ctg cag cag ctg ctg aag ggc cag gag aca     1104
 Leu Ser Ala Ile Arg Gln Leu Gln Gln Leu Leu Lys Gly Gln Glu Thr
         355                 360                 365

 cgc ttc gcc gag ggc atc cgc cac atg aag agc cgg ctg gcc gcg ctg     1152
 Arg Phe Ala Glu Gly Ile Arg His Met Lys Ser Arg Leu Ala Ala Leu
     370                 375                 380

 cag aac tct gtg ggc agg agc agt ttt aag ttc ata gca gag ttg agt     1200
 Gln Asn Ser Val Gly Arg Ser Ser Phe Lys Phe Ile Ala Glu Leu Ser
 385                 390                 395                 400

 gga aag cac tgc gtt cct cca cac cct ctg tgc gtg cac aca cac gcg     1248
 Gly Lys His Cys Val Pro Pro His Pro Leu Cys Val His Thr His Ala
                 405                 410                 415

 cac gca cac gcg cac gca cac gca cac gca gac gca cgc aca cgc aca     1296
 His Ala His Ala His Ala His Ala His Ala Asp Ala Arg Thr Arg Thr
             420                 425                 430

 cac gca cgc aca cac aca agc acg cgc aca cgc acg cac acg cac aca     1344
 His Ala Arg Thr His Thr Ser Thr Arg Thr Arg Thr His Thr His Thr
         435                 440                 445

 cgc gca cgc aca cac gca cgc aca cgc aga cgc aca cgc acg cac acg     1392
 Arg Ala Arg Thr His Ala Arg Thr Arg Arg Arg Thr Arg Thr His Thr
     450                 455                 460

 cac aca cgc acg cac aca cac gca cac aca agc acg cat aca cgc acg     1440
 His Thr Arg Thr His Thr His Ala His Thr Ser Thr His Thr Arg Thr
 465                 470                 475                 480

 cac acg cgc aca cac aca cac aca cac tca gcc cga gcc agt gca ata     1488
 His Thr Arg Thr His Thr His Thr His Ser Ala Arg Ala Ser Ala Ile
                 485                 490                 495

 cac tgg ttc cag tcc atg acc aag gtt att acc act ggg ggc caa ctt     1536
 His Trp Phe Gln Ser Met Thr Lys Val Ile Thr Thr Gly Gly Gln Leu
             500                 505                 510

 gga gct tta ctc aag gaa ggc gat gca gca atg ggc aga tat tcc cca     1584
 Gly Ala Leu Leu Lys Glu Gly Asp Ala Ala Met Gly Arg Tyr Ser Pro
         515                 520                 525

 atc acc aaa ggc cac cga gca tcc tcg gag ggt ccg gca cct ccc tcc     1632
 Ile Thr Lys Gly His Arg Ala Ser Ser Glu Gly Pro Ala Pro Pro Ser
     530                 535                 540

 gcc cca gct cag gct gcc acg gct gct cct caa aga acc cta ggt tgt     1680
 Ala Pro Ala Gln Ala Ala Thr Ala Ala Pro Gln Arg Thr Leu Gly Cys
 545                 550                 555                 560

 gtc cgg ccc aga cat ctg tct ggc tgt gcc ttc acc ttc aac tcg ttc     1728
 Val Arg Pro Arg His Leu Ser Gly Cys Ala Phe Thr Phe Asn Ser Phe
                 565                 570                 575

 tgt ttc ctg ccc ggc tct gaa cac ccc cgc aga cgg cag aaa gtt tgg     1776
 Cys Phe Leu Pro Gly Ser Glu His Pro Arg Arg Arg Gln Lys Val Trp
             580                 585                 590

 aag caa gta ctt agt gga tca cga agt cca ttt tac ctg caa ccc tgg     1824
 Lys Gln Val Leu Ser Gly Ser Arg Ser Pro Phe Tyr Leu Gln Pro Trp
         595                 600                 605

 gtt ccg gct ggt cgg gcc cag cag cgt gcc tcc tgc ata gcc ctt ttt     1872
 Val Pro Ala Gly Arg Ala Gln Gln Arg Ala Ser Cys Ile Ala Leu Phe
     610                 615                 620

 cct tct acc ctg act tcc aca cca aag agc tgc atg atg cag ccc acc     1920
 Pro Ser Thr Leu Thr Ser Thr Pro Lys Ser Cys Met Met Gln Pro Thr
 625                 630                 635                 640

 ttc ggg atg cct act cag aca gca tgt gct atc aaa aac ttg gga agg     1968
 Phe Gly Met Pro Thr Gln Thr Ala Cys Ala Ile Lys Asn Leu Gly Arg
                 645                 650                 655

 act aac tca ggg aac aag cca att ttt act gag cac cag cca ttc aca     2016
 Thr Asn Ser Gly Asn Lys Pro Ile Phe Thr Glu His Gln Pro Phe Thr
             660                 665                 670

 aag ctg gtg cca gat gcc agg gac tca atg tcg aat ccc aca gac acg     2064
 Lys Leu Val Pro Asp Ala Arg Asp Ser Met Ser Asn Pro Thr Asp Thr
         675                 680                 685

 acc ctg gcc tct ggg gtg cac agg cta aga ggg gag gca aag caa agc     2112
 Thr Leu Ala Ser Gly Val His Arg Leu Arg Gly Glu Ala Lys Gln Ser
     690                 695                 700

 agg cag cca cac acc aag gga agc gag ctg acg ttt gtg ata aca gat     2160
 Arg Gln Pro His Thr Lys Gly Ser Glu Leu Thr Phe Val Ile Thr Asp
 705                 710                 715                 720

 aaa gag agt ctg aat gca gcc tgt cta gaa atg aat aca ctg ggt gga     2208
 Lys Glu Ser Leu Asn Ala Ala Cys Leu Glu Met Asn Thr Leu Gly Gly
                 725                 730                 735

 tcc aga gag gga gac aga gtg tac ggt cct ggg aca gct gtg cgt ttc     2256
 Ser Arg Glu Gly Asp Arg Val Tyr Gly Pro Gly Thr Ala Val Arg Phe
             740                 745                 750

 tct gct gca ccg atg atc ccc aac acc cat cca cat ggt tca ggt aca     2304
 Ser Ala Ala Pro Met Ile Pro Asn Thr His Pro His Gly Ser Gly Thr
         755                 760                 765

 gat cag gct caa tgc ctt ctt ttg gca ggc agc aaa gga gag acc aca     2352
 Asp Gln Ala Gln Cys Leu Leu Leu Ala Gly Ser Lys Gly Glu Thr Thr
     770                 775                 780

 gca ctg gcc cta ctg ggg cca agc tac aag ata ctg gtg ttc aca ttt     2400
 Ala Leu Ala Leu Leu Gly Pro Ser Tyr Lys Ile Leu Val Phe Thr Phe
 785                 790                 795                 800

 tct ggc tct ctg ccc aca act tca cgg cct agt gat ctg ccc act tcc     2448
 Ser Gly Ser Leu Pro Thr Thr Ser Arg Pro Ser Asp Leu Pro Thr Ser
                 805                 810                 815

 aga cta cgc tgg tgc tgg ctg atg gag cag aag ggt tgt ggg tta cag     2496
 Arg Leu Arg Trp Cys Trp Leu Met Glu Gln Lys Gly Cys Gly Leu Gln
             820                 825                 830

 ggc ctg act caa agg caa tgt ggg cag atg ccc aca ggt agc cac ttc     2544
 Gly Leu Thr Gln Arg Gln Cys Gly Gln Met Pro Thr Gly Ser His Phe
         835                 840                 845

 tgt ctg gct aca gct gtc tac act gca cct ttg caa att aga aaa tgg     2592
 Cys Leu Ala Thr Ala Val Tyr Thr Ala Pro Leu Gln Ile Arg Lys Trp
     850                 855                 860

 tgc ctg tgg gtg ggg tat ggc cag ctc ata ggc cag ctc ctg cat gca     2640
 Cys Leu Trp Val Gly Tyr Gly Gln Leu Ile Gly Gln Leu Leu His Ala
 865                 870                 875                 880

 gag ccc cag ggc ctg ctg aat gga gat gca ata ggg ctg cat atc agc     2688
 Glu Pro Gln Gly Leu Leu Asn Gly Asp Ala Ile Gly Leu His Ile Ser
                 885                 890                 895

 ccc atc ggc ccc ctg gca gct ctt gcg ggt gga gag ggt gga aag agt     2736
 Pro Ile Gly Pro Leu Ala Ala Leu Ala Gly Gly Glu Gly Gly Lys Ser
             900                 905                 910

 atc agt gaa tgc tcc agc cag cct tgt caa aat ggt ggt aca tgt gta     2784
 Ile Ser Glu Cys Ser Ser Gln Pro Cys Gln Asn Gly Gly Thr Cys Val
         915                 920                 925

 gaa gga gtc aac cag tac aga tgc att tgt cct cca gga agg act ggg     2832
 Glu Gly Val Asn Gln Tyr Arg Cys Ile Cys Pro Pro Gly Arg Thr Gly
     930                 935                 940

 aac cgc tgt cag cat cag gcc cag act gcc gcc ccc gag ggc agc gtg     2880
 Asn Arg Cys Gln His Gln Ala Gln Thr Ala Ala Pro Glu Gly Ser Val
 945                 950                 955                 960

 gcc ggc gac tcc gcc ttc agc cgc gcg ccg cgc tgt gcg cag gtg gag     2928
 Ala Gly Asp Ser Ala Phe Ser Arg Ala Pro Arg Cys Ala Gln Val Glu
                 965                 970                 975

 cgg gct cag cac tgc agc tgc gag gcc gga ttc cac ctg agc ggc gcc     2976
 Arg Ala Gln His Cys Ser Cys Glu Ala Gly Phe His Leu Ser Gly Ala
             980                 985                 990

 gcc ggc gac agc gtc tgc cag gac gtg aac gag tgt gag ctc tac ggg     3024
 Ala Gly Asp Ser Val Cys Gln Asp Val Asn Glu Cys Glu Leu Tyr Gly
         995                1000                1005

 cag gag ggg cgc ccc cgg ctc tgc atg cac gcc tgc gtg aac acc ccg     3072
 Gln Glu Gly Arg Pro Arg Leu Cys Met His Ala Cys Val Asn Thr Pro
    1010                1015                1020

 ggc tct tac cgt tgc acc tgc ccc ggt gga tac cga act ctg gct gac     3120
 Gly Ser Tyr Arg Cys Thr Cys Pro Gly Gly Tyr Arg Thr Leu Ala Asp
1025                1030                1035                1040

 ggg aag agc tgt gag gat gtg gat gaa tgt gtg ggc ctg cag ccg gtg     3168
 Gly Lys Ser Cys Glu Asp Val Asp Glu Cys Val Gly Leu Gln Pro Val
                1045                1050                1055

 tgc ccc cag ggg acc aca tgc atc aac acc ggt gga agc ttc cag tgt     3216
 Cys Pro Gln Gly Thr Thr Cys Ile Asn Thr Gly Gly Ser Phe Gln Cys
            1060                1065                1070

 gtc agc cct gag tgc ccc gag ggc agc ggc aat gtg agc tac gtg aag     3264
 Val Ser Pro Glu Cys Pro Glu Gly Ser Gly Asn Val Ser Tyr Val Lys
        1075                1080                1085

 acg tct cca ttc cag tgt gag cgg aac ccc tgc ccc atg gac agc agg     3312
 Thr Ser Pro Phe Gln Cys Glu Arg Asn Pro Cys Pro Met Asp Ser Arg
    1090                1095                1100

 ccc tgc cgc cat ctg ccc aag acc atc tcc ttc cat tac ctc tct ctg     3360
 Pro Cys Arg His Leu Pro Lys Thr Ile Ser Phe His Tyr Leu Ser Leu
1105                1110                1115                1120

 cct tcc aac ctg aag acg ccc atc acg ctc ttc cgc atg gcc aca gcc     3408
 Pro Ser Asn Leu Lys Thr Pro Ile Thr Leu Phe Arg Met Ala Thr Ala
                1125                1130                1135

 tct gcc ccc ggc cga gct ggg ccc aac agc ctg cgg ttt ggg atc gtg     3456
 Ser Ala Pro Gly Arg Ala Gly Pro Asn Ser Leu Arg Phe Gly Ile Val
            1140                1145                1150

 ggt ggg aac agc cgc ggc cac ttt gtg atg cag cgt tca gac cgg cag     3504
 Gly Gly Asn Ser Arg Gly His Phe Val Met Gln Arg Ser Asp Arg Gln
        1155                1160                1165

 act ggg gat ctg atc ctt gtg cag aac ctg gag ggg cct cag acg ctg     3552
 Thr Gly Asp Leu Ile Leu Val Gln Asn Leu Glu Gly Pro Gln Thr Leu
    1170                1175                1180

 gag gtg gac gtc gac atg tcg gaa tac ctg gac cgc tcc ttc cag gcc     3600
 Glu Val Asp Val Asp Met Ser Glu Tyr Leu Asp Arg Ser Phe Gln Ala
1185                1190                1195                1200

 aac cac gtg tcc aag gag ggg gtg gct gac tct ctt cct gtc tgg gtt     3648
 Asn His Val Ser Lys Glu Gly Val Ala Asp Ser Leu Pro Val Trp Val
                1205                1210                1215

 gga tac act gga ata aat gag tca gag aac aca gag gtg atg ttt ggg     3696
 Gly Tyr Thr Gly Ile Asn Glu Ser Glu Asn Thr Glu Val Met Phe Gly
            1220                1225                1230

 act gtt cca cat tat aaa ttt gtt ttg acc aca tgg gag att gag aat     3744
 Thr Val Pro His Tyr Lys Phe Val Leu Thr Thr Trp Glu Ile Glu Asn
        1235                1240                1245

 aca gct ttg gat ggg gca ggt aca cta aat gcc ctt cca cag ctt cca     3792
 Thr Ala Leu Asp Gly Ala Gly Thr Leu Asn Ala Leu Pro Gln Leu Pro
    1250                1255                1260

 gaa tgt cag gga gga caa ttt gag aca agg agt gtg agg gtt gct gag     3840
 Glu Cys Gln Gly Gly Gln Phe Glu Thr Arg Ser Val Arg Val Ala Glu
1265                1270                1275                1280

 atc aaa gga ggg tgg aaa gcg aga tgt acc ctt gcc tgg ttc act aag     3888
 Ile Lys Gly Gly Trp Lys Ala Arg Cys Thr Leu Ala Trp Phe Thr Lys
                1285                1290                1295

 gct gcc tct gac aac aga gga aat gag ctg aat aca atg aat gta gtt     3936
 Ala Ala Ser Asp Asn Arg Gly Asn Glu Leu Asn Thr Met Asn Val Val
            1300                1305                1310

 ttt ggt gaa gag gat ggc gag ggg gag aaa cat gga ctt tgg gaa gaa     3984
 Phe Gly Glu Glu Asp Gly Glu Gly Glu Lys His Gly Leu Trp Glu Glu
        1315                1320                1325

 gaa tgt agg ttt gct tct tag                                         4005
 Glu Cys Arg Phe Ala Ser 
    1330





      <210> 632
      <211> 531
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (1)..(531)

      <400> 632
  atg gaa atg agg gtc ccc gct cag ctc ctg ggg ctc ctg ctg ctc tgg      48
  Met Glu Met Arg Val Pro Ala Gln Leu Leu Gly Leu Leu Leu Leu Trp
    1               5                  10                  15

 ctc cga ggt gcc aga tgt gac atc cag gtg acc cag tct cca tct tcc       96
 Leu Arg Gly Ala Arg Cys Asp Ile Gln Val Thr Gln Ser Pro Ser Ser
              20                  25                  30

 ctg tct gcg tct gta gga gac aga gtc acc atc acc tgc cgg gca agt      144
 Leu Ser Ala Ser Val Gly Asp Arg Val Thr Ile Thr Cys Arg Ala Ser
          35                  40                  45

 cag ggc att agc aat ggg tta tcc tgg tat cag cag aaa cca ggg caa      192
 Gln Gly Ile Ser Asn Gly Leu Ser Trp Tyr Gln Gln Lys Pro Gly Gln
      50                  55                  60

 gcc cct acg ctc ctg atc tat gct gca tcc agt ttg cag tcg ggg gtc      240
 Ala Pro Thr Leu Leu Ile Tyr Ala Ala Ser Ser Leu Gln Ser Gly Val
  65                  70                  75                  80

 cca tct cgg ttc agt ggc agt gga tct ggg aca gat ttc act ctc acc      288
 Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr
                  85                  90                  95

 atc agc agc ctg cag cct gaa gat gtt gca act tat tac tgt cta cag      336
 Ile Ser Ser Leu Gln Pro Glu Asp Val Ala Thr Tyr Tyr Cys Leu Gln
             100                 105                 110

 gat tat act acc cca ttc aca gtg tta caa gcc ata aca aaa acc ccc      384
 Asp Tyr Thr Thr Pro Phe Thr Val Leu Gln Ala Ile Thr Lys Thr Pro
         115                 120                 125

 cag aga agc aga tgt aaa gaa aaa ttg aaa ggc agt gga cgg cca tca      432
 Gln Arg Ser Arg Cys Lys Glu Lys Leu Lys Gly Ser Gly Arg Pro Ser
     130                 135                 140

 gta gaa ggg tgt gag gca caa gtt att gag gta cat gaa gag act gac      480
 Val Glu Gly Cys Glu Ala Gln Val Ile Glu Val His Glu Glu Thr Asp
 145                 150                 155                 160

 agt cat gat cct tat gaa gca tta gtt gaa ggg tca cag agg tac gca      528
 Ser His Asp Pro Tyr Glu Ala Leu Val Glu Gly Ser Gln Arg Tyr Ala
                 165                 170                 175

 taa                                                                  531
 






      <210> 633
      <211> 2658
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (1)..(2658)

      <400> 633
  atg ggt ctg tgg gca gga gag ggc aca ctc cag tgg tgt ctg agg ctg      48
  Met Gly Leu Trp Ala Gly Glu Gly Thr Leu Gln Trp Cys Leu Arg Leu
    1               5                  10                  15

 ttg ctt cag aag gtt gga ggc aga cca gct acg agc tgg agc aca gga       96
 Leu Leu Gln Lys Val Gly Gly Arg Pro Ala Thr Ser Trp Ser Thr Gly
              20                  25                  30

 aga aaa gga aca gaa gag ggg atc cat cca tat gtg act gag ata tgg      144
 Arg Lys Gly Thr Glu Glu Gly Ile His Pro Tyr Val Thr Glu Ile Trp
          35                  40                  45

 tcg aat cta aac caa gtc aca aaa tca gtg ata tcc att gtg cgg agg      192
 Ser Asn Leu Asn Gln Val Thr Lys Ser Val Ile Ser Ile Val Arg Arg
      50                  55                  60

 tat cca cta gat gcc act gcc aag tta aga gag ctg aat cct aat cgt      240
 Tyr Pro Leu Asp Ala Thr Ala Lys Leu Arg Glu Leu Asn Pro Asn Arg
  65                  70                  75                  80

 gag gtt ttg agg gga gat cat tca cag aag tct ctg tct cct ttc atc      288
 Glu Val Leu Arg Gly Asp His Ser Gln Lys Ser Leu Ser Pro Phe Ile
                  85                  90                  95

 tac agt cgc agc tgt ttt cca gac gcc ttg ctc ctc agg tcg ggg agt      336
 Tyr Ser Arg Ser Cys Phe Pro Asp Ala Leu Leu Leu Arg Ser Gly Ser
             100                 105                 110

 gat ctg atg gcc cag gtt cga gaa act tct ttg ccc tcc ggc tct ggg      384
 Asp Leu Met Ala Gln Val Arg Glu Thr Ser Leu Pro Ser Gly Ser Gly
         115                 120                 125

 gtc cgc tgg atc tcc gga ggt ggg gga gga gcc tct cct gag gag gcg      432
 Val Arg Trp Ile Ser Gly Gly Gly Gly Gly Ala Ser Pro Glu Glu Ala
     130                 135                 140

 gtt gag aag gcg ggg aaa atg gag gag gcg gcg gcg ggg gct acg aag      480
 Val Glu Lys Ala Gly Lys Met Glu Glu Ala Ala Ala Gly Ala Thr Lys
 145                 150                 155                 160

 gcg tct tcg aga cgt gaa gcc gag gag atg aag ctg gag cca tta caa      528
 Ala Ser Ser Arg Arg Glu Ala Glu Glu Met Lys Leu Glu Pro Leu Gln
                 165                 170                 175

 gag cgt gag ccc gcg ccg gag gag aac ttg acg tgg agc agc agc ggc      576
 Glu Arg Glu Pro Ala Pro Glu Glu Asn Leu Thr Trp Ser Ser Ser Gly
             180                 185                 190

 ggc gac gag aag gtg ctc cct tca atc ccc ctt cgc tgt cac agc agc      624
 Gly Asp Glu Lys Val Leu Pro Ser Ile Pro Leu Arg Cys His Ser Ser
         195                 200                 205

 tcc tcg ccc gtt tgc ccg cgc cgc aag ccc cgc cct cgg ccc cag ccc      672
 Ser Ser Pro Val Cys Pro Arg Arg Lys Pro Arg Pro Arg Pro Gln Pro
     210                 215                 220

 cgg gcc cgc tcc cgc agc cag cct ggg ctc tcg gcc cca ccc ccg cct      720
 Arg Ala Arg Ser Arg Ser Gln Pro Gly Leu Ser Ala Pro Pro Pro Pro
 225                 230                 235                 240

 cca gcc cgg ccc ccg ccc ccg ccg cca ccc ccg ccc cca ccc gca ccg      768
 Pro Ala Arg Pro Pro Pro Pro Pro Pro Pro Pro Pro Pro Pro Ala Pro
                 245                 250                 255

 cgg ccc agg gcc tgg cgt gga tcc cgg cgc aga tcc cgg cct ggg tcc      816
 Arg Pro Arg Ala Trp Arg Gly Ser Arg Arg Arg Ser Arg Pro Gly Ser
             260                 265                 270

 agg cct cag aca cgg aga agc tgc tct ggt gac cta gac ggg tcg ggg      864
 Arg Pro Gln Thr Arg Arg Ser Cys Ser Gly Asp Leu Asp Gly Ser Gly
         275                 280                 285

 gat cct ggc ggc tta ggg gac tgg ttg ctg gag gtc gag ttt ggt cag      912
 Asp Pro Gly Gly Leu Gly Asp Trp Leu Leu Glu Val Glu Phe Gly Gln
     290                 295                 300

 ggt ccc aca ggc tgc tct cat gtg gag agc ttt aaa gta ggt aag aac      960
 Gly Pro Thr Gly Cys Ser His Val Glu Ser Phe Lys Val Gly Lys Asn
 305                 310                 315                 320

 tgg cag aag aac ctg agg ttg atc tac cag cgt ttc gtt tgg agt ggg     1008
 Trp Gln Lys Asn Leu Arg Leu Ile Tyr Gln Arg Phe Val Trp Ser Gly
                 325                 330                 335

 acc cca gag act agg aaa cgt aaa gca aag tca tgc atc tgt cac gta     1056
 Thr Pro Glu Thr Arg Lys Arg Lys Ala Lys Ser Cys Ile Cys His Val
             340                 345                 350

 tgt agt acc cat atg aac aga ctc cac tct tgt ctc tcc tgt gtc ttt     1104
 Cys Ser Thr His Met Asn Arg Leu His Ser Cys Leu Ser Cys Val Phe
         355                 360                 365

 ttt ggc tgc ttc act gag aaa cat att cac aaa cat gca gaa aca aag     1152
 Phe Gly Cys Phe Thr Glu Lys His Ile His Lys His Ala Glu Thr Lys
     370                 375                 380

 cag cac cat tta gct gta gac ctt tat cat ggg gtc ata tat tgc ttc     1200
 Gln His His Leu Ala Val Asp Leu Tyr His Gly Val Ile Tyr Cys Phe
 385                 390                 395                 400

 atg tgt aag gat tat gta tat gac aaa gac ata gaa cag att gcc aaa     1248
 Met Cys Lys Asp Tyr Val Tyr Asp Lys Asp Ile Glu Gln Ile Ala Lys
                 405                 410                 415

 gaa aca aaa gaa aaa att ttg aga tta tta act tcc acc tca aca gat     1296
 Glu Thr Lys Glu Lys Ile Leu Arg Leu Leu Thr Ser Thr Ser Thr Asp
             420                 425                 430

 gtt tct cat caa cag ttt atg aca tca ggg ttt gaa gac aag caa tca     1344
 Val Ser His Gln Gln Phe Met Thr Ser Gly Phe Glu Asp Lys Gln Ser
         435                 440                 445

 acc tgt gag aca aag gaa cag gag cca aaa ttg gtg aaa ccc aag aaa     1392
 Thr Cys Glu Thr Lys Glu Gln Glu Pro Lys Leu Val Lys Pro Lys Lys
     450                 455                 460

 aag aga aga aaa aag tca gtc tat act gta ggc ctg aga ggg cta atc     1440
 Lys Arg Arg Lys Lys Ser Val Tyr Thr Val Gly Leu Arg Gly Leu Ile
 465                 470                 475                 480

 aat ctt ggg aac act tgt ttt atg aat tgt att gtc cag gca ctt acc     1488
 Asn Leu Gly Asn Thr Cys Phe Met Asn Cys Ile Val Gln Ala Leu Thr
                 485                 490                 495

 cat att cct cta ctg aaa gat ttc ttc ctc tct gac aag cac aaa tgt     1536
 His Ile Pro Leu Leu Lys Asp Phe Phe Leu Ser Asp Lys His Lys Cys
             500                 505                 510

 ata atg aca agc ccc agc ttg tgt ctg gtc tgt gaa atg tct tcg ctt     1584
 Ile Met Thr Ser Pro Ser Leu Cys Leu Val Cys Glu Met Ser Ser Leu
         515                 520                 525

 ttt cat gct atg tac tct ggg agc cga act cct cac att ccc tat aag     1632
 Phe His Ala Met Tyr Ser Gly Ser Arg Thr Pro His Ile Pro Tyr Lys
     530                 535                 540

 tta ctg cat ctg ata tgg atc cat gca gaa cat tta gca ggg tac agg     1680
 Leu Leu His Leu Ile Trp Ile His Ala Glu His Leu Ala Gly Tyr Arg
 545                 550                 555                 560

 cag cag gat gcc cat gag ttc ctt att gca ata tta gac gtg cta cat     1728
 Gln Gln Asp Ala His Glu Phe Leu Ile Ala Ile Leu Asp Val Leu His
                 565                 570                 575

 aga cac agc aaa gat gat agt ggt ggg cag gag gcc aat aac ccc aac     1776
 Arg His Ser Lys Asp Asp Ser Gly Gly Gln Glu Ala Asn Asn Pro Asn
             580                 585                 590

 tgc tgt aac tgc atc ata gac caa atc ttt aca ggt ggc ctg caa tca     1824
 Cys Cys Asn Cys Ile Ile Asp Gln Ile Phe Thr Gly Gly Leu Gln Ser
         595                 600                 605

 gat gtc aca tgt caa gcc tgc cat agt gtt tct acc acc ata gac cca     1872
 Asp Val Thr Cys Gln Ala Cys His Ser Val Ser Thr Thr Ile Asp Pro
     610                 615                 620

 tgc tgg gac atc agt ttg gac ttg cct ggc tct tgt gcc aca ttc gat     1920
 Cys Trp Asp Ile Ser Leu Asp Leu Pro Gly Ser Cys Ala Thr Phe Asp
 625                 630                 635                 640

 tcc cag aac cca gag agg gct gac agc aca gtg agc agg gat gac cac     1968
 Ser Gln Asn Pro Glu Arg Ala Asp Ser Thr Val Ser Arg Asp Asp His
                 645                 650                 655

 ata cca gga atc ccc tca ctt aca gac tgt cta cag tgg ttt aca agg     2016
 Ile Pro Gly Ile Pro Ser Leu Thr Asp Cys Leu Gln Trp Phe Thr Arg
             660                 665                 670

 cca gag cac cta gga agc agt gcc aaa atc aaa tgc aat agt tgc caa     2064
 Pro Glu His Leu Gly Ser Ser Ala Lys Ile Lys Cys Asn Ser Cys Gln
         675                 680                 685

 agc tac cag gag tct act aaa cag ctc aca atg aaa aaa tta ccc att     2112
 Ser Tyr Gln Glu Ser Thr Lys Gln Leu Thr Met Lys Lys Leu Pro Ile
     690                 695                 700

 gtg gct tgt ttt cat ctc aag cgg ttt gag cat gta ggc aaa cag agg     2160
 Val Ala Cys Phe His Leu Lys Arg Phe Glu His Val Gly Lys Gln Arg
 705                 710                 715                 720

 cga aag att aat acc ttt atc tcc ttt ccc ttg gag ctg gac atg act     2208
 Arg Lys Ile Asn Thr Phe Ile Ser Phe Pro Leu Glu Leu Asp Met Thr
                 725                 730                 735

 ccg ttt ttg gcc tct act aaa gag agc aga atg aaa gaa ggc cag cca     2256
 Pro Phe Leu Ala Ser Thr Lys Glu Ser Arg Met Lys Glu Gly Gln Pro
             740                 745                 750

 cca aca gat tgt gtg ccc aat gag aat aag tat tcc ttg ttt gca gtg     2304
 Pro Thr Asp Cys Val Pro Asn Glu Asn Lys Tyr Ser Leu Phe Ala Val
         755                 760                 765

 att aat cac cat gga act ttg gaa agt ggc cac tat acc agc ttc atc     2352
 Ile Asn His His Gly Thr Leu Glu Ser Gly His Tyr Thr Ser Phe Ile
     770                 775                 780

 cgg caa caa aag gac cag tgg ttc agc tgt gat gat gcc atc atc acc     2400
 Arg Gln Gln Lys Asp Gln Trp Phe Ser Cys Asp Asp Ala Ile Ile Thr
 785                 790                 795                 800

 aag gct acc att gag gac tta ctc tac agt gaa ggc ctg cag ggc tcc     2448
 Lys Ala Thr Ile Glu Asp Leu Leu Tyr Ser Glu Gly Leu Gln Gly Ser
                 805                 810                 815

 ttc ttt gac tat tca cct ggt ggc ttt tac tcc tcc ttc aag acc caa     2496
 Phe Phe Asp Tyr Ser Pro Gly Gly Phe Tyr Ser Ser Phe Lys Thr Gln
             820                 825                 830

 ctc aca gat gac ttc tct gga gtc ttc cct gaa tgc tct agg cag gga     2544
 Leu Thr Asp Asp Phe Ser Gly Val Phe Pro Glu Cys Ser Arg Gln Gly
         835                 840                 845

 agg gca ttt tgt cag cca cag cta agc aaa gag ttg ctc cac tct ggg     2592
 Arg Ala Phe Cys Gln Pro Gln Leu Ser Lys Glu Leu Leu His Ser Gly
     850                 855                 860

 tta gca gac cta gaa gga aat gct gag tca gtc aag agc cca aag gct     2640
 Leu Ala Asp Leu Glu Gly Asn Ala Glu Ser Val Lys Ser Pro Lys Ala
 865                 870                 875                 880

 aaa gaa cct gga gtc tga                                             2658
 Lys Glu Pro Gly Val 
                 885





      <210> 634
      <211> 4398
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (1)..(4398)

      <400> 634
  atg gcc acc ccc tac tct tca tcg ttg ctg gct gcc tcg tgc tgc ctg      48
  Met Ala Thr Pro Tyr Ser Ser Ser Leu Leu Ala Ala Ser Cys Cys Leu
    1               5                  10                  15

 aat tct gta gcc ctc atc cgc act agc ctg gca acc act gac ctt tta       96
 Asn Ser Val Ala Leu Ile Arg Thr Ser Leu Ala Thr Thr Asp Leu Leu
              20                  25                  30

 gtt gcc agg caa ccc cat gac cac cag acc aga cct ggt tcc cca cac      144
 Val Ala Arg Gln Pro His Asp His Gln Thr Arg Pro Gly Ser Pro His
          35                  40                  45

 tgc cac aga gct ccc cgc cct tca gct ggg atg aag acc cgc agc tca      192
 Cys His Arg Ala Pro Arg Pro Ser Ala Gly Met Lys Thr Arg Ser Ser
      50                  55                  60

 cgc cac act cag gga gcc cag ccc ggg ctg gca gac cag gcg gca aag      240
 Arg His Thr Gln Gly Ala Gln Pro Gly Leu Ala Asp Gln Ala Ala Lys
  65                  70                  75                  80

 ctg tcc tac gcc tcc gcc gag tcg ctg gag acc atg tcg gag gcc gag      288
 Leu Ser Tyr Ala Ser Ala Glu Ser Leu Glu Thr Met Ser Glu Ala Glu
                  85                  90                  95

 ctg ccc ctg ggc ttc agc agg atg aac cgc ttc cga cag agc ctg cct      336
 Leu Pro Leu Gly Phe Ser Arg Met Asn Arg Phe Arg Gln Ser Leu Pro
             100                 105                 110

 ctc tcc cgc tcg gcc agc cag acc aag ctg cgc tcc cca gct ccg aaa      384
 Leu Ser Arg Ser Ala Ser Gln Thr Lys Leu Arg Ser Pro Ala Pro Lys
         115                 120                 125

 agc tcc ccg cgc tct cct gga ggg cgg cgt gga gac ggc agc agt gac      432
 Ser Ser Pro Arg Ser Pro Gly Gly Arg Arg Gly Asp Gly Ser Ser Asp
     130                 135                 140

 agc gag ggc ggc gtc tcc ttc gca ggg gtg ctg ttc ctg cag ttc ggg      480
 Ser Glu Gly Gly Val Ser Phe Ala Gly Val Leu Phe Leu Gln Phe Gly
 145                 150                 155                 160

 gag gag act cgg cgc gtg cac atc acg cac gag gtc agc agc ctg gac      528
 Glu Glu Thr Arg Arg Val His Ile Thr His Glu Val Ser Ser Leu Asp
                 165                 170                 175

 acg ctg cac gca ctc atc gcg cac atg ttc ccg cag aag ctc acc atg      576
 Thr Leu His Ala Leu Ile Ala His Met Phe Pro Gln Lys Leu Thr Met
             180                 185                 190

 ggc atg ctt aag tcg ccc aat acc gcc atc ctc atc aaa gac gag gct      624
 Gly Met Leu Lys Ser Pro Asn Thr Ala Ile Leu Ile Lys Asp Glu Ala
         195                 200                 205

 cgc aac gtc ttc tac gag ctg gag gac gtc cgg gac atc cag gac cgc      672
 Arg Asn Val Phe Tyr Glu Leu Glu Asp Val Arg Asp Ile Gln Asp Arg
     210                 215                 220

 agt att atc aag atc tac aga aag gag ccc ctc tac gct gcc ttc cct      720
 Ser Ile Ile Lys Ile Tyr Arg Lys Glu Pro Leu Tyr Ala Ala Phe Pro
 225                 230                 235                 240

 ggc tca cat ctc acc aac ggg gac ctc cgg aga gag atg gtg tac gca      768
 Gly Ser His Leu Thr Asn Gly Asp Leu Arg Arg Glu Met Val Tyr Ala
                 245                 250                 255

 tcg cgg gag tcc tcg ccc acg cgg cgc ctc aac aac ctg tca cca gcg      816
 Ser Arg Glu Ser Ser Pro Thr Arg Arg Leu Asn Asn Leu Ser Pro Ala
             260                 265                 270

 ccg cac ctg gca tcc ggc tcg ccg ccg ccc ggg ctg ccg tcg ggg ctg      864
 Pro His Leu Ala Ser Gly Ser Pro Pro Pro Gly Leu Pro Ser Gly Leu
         275                 280                 285

 ccg tcc ggg ctg cag tcc ggt tcg ccg tcg cgt tcg cgc cta tcg tac      912
 Pro Ser Gly Leu Gln Ser Gly Ser Pro Ser Arg Ser Arg Leu Ser Tyr
     290                 295                 300

 gcc ggg ggg cgc ccg cct tcg tac gcc ggc agc ccg gtg cac cac gcg      960
 Ala Gly Gly Arg Pro Pro Ser Tyr Ala Gly Ser Pro Val His His Ala
 305                 310                 315                 320

 gcc gag agg ctg gga ggc gcc ccg gcc gcc cag ggc gtc agc ccc agc     1008
 Ala Glu Arg Leu Gly Gly Ala Pro Ala Ala Gln Gly Val Ser Pro Ser
                 325                 330                 335

 ccc agc gcc atc ctg gag cgg cgc gac gtg aag ccg gac gag gac ctg     1056
 Pro Ser Ala Ile Leu Glu Arg Arg Asp Val Lys Pro Asp Glu Asp Leu
             340                 345                 350

 gcg agc aag gcg ggc ggc atg gtg ctg gtg aaa ggc gag ggc ctc tat     1104
 Ala Ser Lys Ala Gly Gly Met Val Leu Val Lys Gly Glu Gly Leu Tyr
         355                 360                 365

 gct gac ccc tac ggg ctg ctg cac gag ggc cgt ctg agc ctg gcc gcg     1152
 Ala Asp Pro Tyr Gly Leu Leu His Glu Gly Arg Leu Ser Leu Ala Ala
     370                 375                 380

 gcc gcc ggc gac ccg ttc gcc tac ccg ggc gcc ggc ggc ctc tac aag     1200
 Ala Ala Gly Asp Pro Phe Ala Tyr Pro Gly Ala Gly Gly Leu Tyr Lys
 385                 390                 395                 400

 cgc ggc tcg gtg cgc tcg ctc agc acc tac tcg gcc gcc gcg ctg cag     1248
 Arg Gly Ser Val Arg Ser Leu Ser Thr Tyr Ser Ala Ala Ala Leu Gln
                 405                 410                 415

 tcc gat ctg gag gac tcc ctg tac aag gcg gcg ggc ggc ggc ggc ccg     1296
 Ser Asp Leu Glu Asp Ser Leu Tyr Lys Ala Ala Gly Gly Gly Gly Pro
             420                 425                 430

 ctg tac ggc gac ggc tac ggc ttc cgc ctg ccg cct tcg tca ccg cag     1344
 Leu Tyr Gly Asp Gly Tyr Gly Phe Arg Leu Pro Pro Ser Ser Pro Gln
         435                 440                 445

 aag ctg gcc gac gtg gca gca ccc ccc gga ggt ccc ccg cca ccg cac     1392
 Lys Leu Ala Asp Val Ala Ala Pro Pro Gly Gly Pro Pro Pro Pro His
     450                 455                 460

 agc ccc tac tcg ggg ccg ccc agc cgc ggc tcg cca gtg cgc cag tcc     1440
 Ser Pro Tyr Ser Gly Pro Pro Ser Arg Gly Ser Pro Val Arg Gln Ser
 465                 470                 475                 480

 ttc cgc aag gac tcg ggc tcc tcg tcc gtc ttt gcc gag agt cct gga     1488
 Phe Arg Lys Asp Ser Gly Ser Ser Ser Val Phe Ala Glu Ser Pro Gly
                 485                 490                 495

 ggg aag acc cgc agc gcg ggg agc gcc tcg acg gcc gga gct ccc cct     1536
 Gly Lys Thr Arg Ser Ala Gly Ser Ala Ser Thr Ala Gly Ala Pro Pro
             500                 505                 510

 tcg gag ctc ttc cct ggg cct ggg gaa cgc tcg ctg gtt ggg ttc ggg     1584
 Ser Glu Leu Phe Pro Gly Pro Gly Glu Arg Ser Leu Val Gly Phe Gly
         515                 520                 525

 ccg cca gtg cca gcc aag gac acg gag acc agg gag cgc atg gag gcc     1632
 Pro Pro Val Pro Ala Lys Asp Thr Glu Thr Arg Glu Arg Met Glu Ala
     530                 535                 540

 atg gag aag cag att gcc agc ctc aca ggc ctg gtg cag agc gcc tta     1680
 Met Glu Lys Gln Ile Ala Ser Leu Thr Gly Leu Val Gln Ser Ala Leu
 545                 550                 555                 560

 ctg cga ggc tct gag cct gag acc ccc agc gag aag att gaa ggc tcc     1728
 Leu Arg Gly Ser Glu Pro Glu Thr Pro Ser Glu Lys Ile Glu Gly Ser
                 565                 570                 575

 aat gga gca gcc acc ccc tca gca ccc tgt ggg tca ggc ggc cgg agc     1776
 Asn Gly Ala Ala Thr Pro Ser Ala Pro Cys Gly Ser Gly Gly Arg Ser
             580                 585                 590

 agc ggg gcc acc ccg gtg tcc ggc ccg ccc ccg ccc tcg gcc agc agc     1824
 Ser Gly Ala Thr Pro Val Ser Gly Pro Pro Pro Pro Ser Ala Ser Ser
         595                 600                 605

 acc ccc gca ggt cag cct acc gcc gtt agc cgg ctg cag atg cag ctt     1872
 Thr Pro Ala Gly Gln Pro Thr Ala Val Ser Arg Leu Gln Met Gln Leu
     610                 615                 620

 cac ctg cga ggc ctg cag aac agc gcc agt gac ttg cgc ggc cag ctc     1920
 His Leu Arg Gly Leu Gln Asn Ser Ala Ser Asp Leu Arg Gly Gln Leu
 625                 630                 635                 640

 cag cag ttg cgc aag ctc cag cta cag aac cag gag tcg gtg cgc gcg     1968
 Gln Gln Leu Arg Lys Leu Gln Leu Gln Asn Gln Glu Ser Val Arg Ala
                 645                 650                 655

 ctg ctg aag cgc acg gag gca gag ctg agc atg cgc gtg tcg gag gcg     2016
 Leu Leu Lys Arg Thr Glu Ala Glu Leu Ser Met Arg Val Ser Glu Ala
             660                 665                 670

 gcg cgg cgg cag gag gac ccg ctg cag cgg cag cgc acc ctg gtg gaa     2064
 Ala Arg Arg Gln Glu Asp Pro Leu Gln Arg Gln Arg Thr Leu Val Glu
         675                 680                 685

 gag gaa cgg ctg cgc tat ctc aac gac gag gag ctt att acc cag cag     2112
 Glu Glu Arg Leu Arg Tyr Leu Asn Asp Glu Glu Leu Ile Thr Gln Gln
     690                 695                 700

 ctc aat gac ctg gag aaa tcg gtg gag aag atc cag aga gac gtg tcc     2160
 Leu Asn Asp Leu Glu Lys Ser Val Glu Lys Ile Gln Arg Asp Val Ser
 705                 710                 715                 720

 cac aac cac cgg ctg gtg ccc ggc cct gag ctg gag gag aag gca ctg     2208
 His Asn His Arg Leu Val Pro Gly Pro Glu Leu Glu Glu Lys Ala Leu
                 725                 730                 735

 gtg ctg aag cag ctc ggg gag acg ctg aca gag ctc aag gct cac ttc     2256
 Val Leu Lys Gln Leu Gly Glu Thr Leu Thr Glu Leu Lys Ala His Phe
             740                 745                 750

 ccg ggc ctg cag agc aag atg cgg gtg gtg ctg cgc gtg gag gtg gag     2304
 Pro Gly Leu Gln Ser Lys Met Arg Val Val Leu Arg Val Glu Val Glu
         755                 760                 765

 gcg gtg aag ttc ctg aag gag gag ccc cag cgc ctg gat ggg ctc ctc     2352
 Ala Val Lys Phe Leu Lys Glu Glu Pro Gln Arg Leu Asp Gly Leu Leu
     770                 775                 780

 aag cgc tgc cgc ggg gtc acg gac acg ctg gcc cag atc cga agg caa     2400
 Lys Arg Cys Arg Gly Val Thr Asp Thr Leu Ala Gln Ile Arg Arg Gln
 785                 790                 795                 800

 gtg gat gag ggt gtg tgg cca ccc ccc aac aat ctc ctg agt cag tcc     2448
 Val Asp Glu Gly Val Trp Pro Pro Pro Asn Asn Leu Leu Ser Gln Ser
                 805                 810                 815

 ccc aag aag gtg acg gca gag act gac ttc aac aag agc gtg gac ttc     2496
 Pro Lys Lys Val Thr Ala Glu Thr Asp Phe Asn Lys Ser Val Asp Phe
             820                 825                 830

 gaa atg cca ccc ccc agc ccc ccg ctg aac ctg cat gag ctg agc ggg     2544
 Glu Met Pro Pro Pro Ser Pro Pro Leu Asn Leu His Glu Leu Ser Gly
         835                 840                 845

 cca gct gaa gga gcc tct ctt acc ccc aag ggg ggc aac ccc acc aaa     2592
 Pro Ala Glu Gly Ala Ser Leu Thr Pro Lys Gly Gly Asn Pro Thr Lys
     850                 855                 860

 ggc ctg gac act cct ggc aag aga agc gtg gac aaa gct gtg tct gtt     2640
 Gly Leu Asp Thr Pro Gly Lys Arg Ser Val Asp Lys Ala Val Ser Val
 865                 870                 875                 880

 gag gct gca gag cga gac tgg gag gag aag cgg gca gcc ctg acc cag     2688
 Glu Ala Ala Glu Arg Asp Trp Glu Glu Lys Arg Ala Ala Leu Thr Gln
                 885                 890                 895

 tac agt gcc aag gac atc aac cgg ctg ctg gaa gag aca cag gca gag     2736
 Tyr Ser Ala Lys Asp Ile Asn Arg Leu Leu Glu Glu Thr Gln Ala Glu
             900                 905                 910

 ctg ctc aag gcc atc cct gac ctg gac tgt gcc agc aag gcc cat cca     2784
 Leu Leu Lys Ala Ile Pro Asp Leu Asp Cys Ala Ser Lys Ala His Pro
         915                 920                 925

 ggc ccg gcc ccc act cca gat cac aag ccc ccc aag gcc ccc cac ggc     2832
 Gly Pro Ala Pro Thr Pro Asp His Lys Pro Pro Lys Ala Pro His Gly
     930                 935                 940

 cag aag gca gcc ccc cga acg gag ccc agt ggg agg agg ggc tca gga     2880
 Gln Lys Ala Ala Pro Arg Thr Glu Pro Ser Gly Arg Arg Gly Ser Gly
 945                 950                 955                 960

 tct gtt caa cca gat cct ggt tta gca gcc cag agg tgg ggc ctg agc     2928
 Ser Val Gln Pro Asp Pro Gly Leu Ala Ala Gln Arg Trp Gly Leu Ser
                 965                 970                 975

 tgc agt tct gac aag ctg cca ggc gct gcc agt gct gct ggt cca cag     2976
 Cys Ser Ser Asp Lys Leu Pro Gly Ala Ala Ser Ala Ala Gly Pro Gln
             980                 985                 990

 aca aca ctt gga gta gca aga gtg ctg tca gga gag gga cag ggc ttg     3024
 Thr Thr Leu Gly Val Ala Arg Val Leu Ser Gly Glu Gly Gln Gly Leu
         995                1000                1005

 ggg ctt gtg tgc agg aga gat gag ttg acc gtg ccc cga tac cgc aca     3072
 Gly Leu Val Cys Arg Arg Asp Glu Leu Thr Val Pro Arg Tyr Arg Thr
    1010                1015                1020

 gag aag ccc tcc aag tcg ccc cca ccg ccc cct ccc cgc cgg agc ttc     3120
 Glu Lys Pro Ser Lys Ser Pro Pro Pro Pro Pro Pro Arg Arg Ser Phe
1025                1030                1035                1040

 ccc tcc tcc cat ggc ctg acc acc aca cgt acc gga gag gtg gtg gtc     3168
 Pro Ser Ser His Gly Leu Thr Thr Thr Arg Thr Gly Glu Val Val Val
                1045                1050                1055

 acc agc aag aag gac tcg gcc ttc atc aag aag gct gag tcc gag gag     3216
 Thr Ser Lys Lys Asp Ser Ala Phe Ile Lys Lys Ala Glu Ser Glu Glu
            1060                1065                1070

 ctg gag gtg cag aag ccc cag gtg aag ctg cgc cgg gct gtg tct gag     3264
 Leu Glu Val Gln Lys Pro Gln Val Lys Leu Arg Arg Ala Val Ser Glu
        1075                1080                1085

 gtg gcc cgc cca gcc tcc aca cca ccc atc atg gcc tcg gcc atc aag     3312
 Val Ala Arg Pro Ala Ser Thr Pro Pro Ile Met Ala Ser Ala Ile Lys
    1090                1095                1100

 gac gag gat gac gag gat cgc atc atc gca gag cta gag gtg ttt gag     3360
 Asp Glu Asp Asp Glu Asp Arg Ile Ile Ala Glu Leu Glu Val Phe Glu
1105                1110                1115                1120

 aga agc tca gtg tct tcc ctc ccc ccc acg ccc cgc cgc cag ctg atc     3408
 Arg Ser Ser Val Ser Ser Leu Pro Pro Thr Pro Arg Arg Gln Leu Ile
                1125                1130                1135

 ccc acc ttg ctg tcc ccc cag gac ctg ggg ccc ccc ggg ggc tca gcc     3456
 Pro Thr Leu Leu Ser Pro Gln Asp Leu Gly Pro Pro Gly Gly Ser Ala
            1140                1145                1150

 cca ggc cct aca cgg aag gct gcc cca ggt ccc agg gcc ttc tgc gtc     3504
 Pro Gly Pro Thr Arg Lys Ala Ala Pro Gly Pro Arg Ala Phe Cys Val
        1155                1160                1165

 cca agg atc atc ttg aca gag tgt gcc ccc aac cct ccc tcc ccg cca     3552
 Pro Arg Ile Ile Leu Thr Glu Cys Ala Pro Asn Pro Pro Ser Pro Pro
    1170                1175                1180

 gag gcc aga ctt gag gaa ctg gga ccc agg aca gct ccc acc cca aga     3600
 Glu Ala Arg Leu Glu Glu Leu Gly Pro Arg Thr Ala Pro Thr Pro Arg
1185                1190                1195                1200

 cct cag acc ctg gct gac agc acg agg ggc tgg gat ggc cca cag tcc     3648
 Pro Gln Thr Leu Ala Asp Ser Thr Arg Gly Trp Asp Gly Pro Gln Ser
                1205                1210                1215

 cca cca ggg gta gtg ggg gag act tct ggg ccg agg agc agc ttc atg     3696
 Pro Pro Gly Val Val Gly Glu Thr Ser Gly Pro Arg Ser Ser Phe Met
            1220                1225                1230

 ccc cgg aag gag ggg gca gct ctg aag aga ctg ggt gga gga ggc agc     3744
 Pro Arg Lys Glu Gly Ala Ala Leu Lys Arg Leu Gly Gly Gly Gly Ser
        1235                1240                1245

 agc cta gag gat gga gga gcc aga gta cag tgt cct cag gga cca gcc     3792
 Ser Leu Glu Asp Gly Gly Ala Arg Val Gln Cys Pro Gln Gly Pro Ala
    1250                1255                1260

 cag gat ggg act cca gag acc tct act gct gac acc tac cca gag gag     3840
 Gln Asp Gly Thr Pro Glu Thr Ser Thr Ala Asp Thr Tyr Pro Glu Glu
1265                1270                1275                1280

 atc ctc aag gac tct gga cat gat gcc caa acc tgc agt agg gag cat     3888
 Ile Leu Lys Asp Ser Gly His Asp Ala Gln Thr Cys Ser Arg Glu His
                1285                1290                1295

 cag ggc cag gct gct gcc aac tca ggc cgc acc acg tgg ggc gcc act     3936
 Gln Gly Gln Ala Ala Ala Asn Ser Gly Arg Thr Thr Trp Gly Ala Thr
            1300                1305                1310

 gcc cag cag atg gac agc ttg gag gag acg ctc cgg gag ctg gaa gcc     3984
 Ala Gln Gln Met Asp Ser Leu Glu Glu Thr Leu Arg Glu Leu Glu Ala
        1315                1320                1325

 acc ctg agc aac atg ggc aca ggc cct gcc atg ggg tcc cct ggc agc     4032
 Thr Leu Ser Asn Met Gly Thr Gly Pro Ala Met Gly Ser Pro Gly Ser
    1330                1335                1340

 ccc cca ccc cta ccc ctc cgc ccc cag agt ggc gga ggc agt gta cca     4080
 Pro Pro Pro Leu Pro Leu Arg Pro Gln Ser Gly Gly Gly Ser Val Pro
1345                1350                1355                1360

 ccc atg aag gtg gtg act ccg ggg gcc tct cgg ctg aag gcg gcc cag     4128
 Pro Met Lys Val Val Thr Pro Gly Ala Ser Arg Leu Lys Ala Ala Gln
                1365                1370                1375

 ggc cag gcg ggc agc ccc gac aaa agc aaa cat ggc aag cag agg gcc     4176
 Gly Gln Ala Gly Ser Pro Asp Lys Ser Lys His Gly Lys Gln Arg Ala
            1380                1385                1390

 gag tac atg cgg atc cag gcc cag cag cag gct cct cga atg cgt gtg     4224
 Glu Tyr Met Arg Ile Gln Ala Gln Gln Gln Ala Pro Arg Met Arg Val
        1395                1400                1405

 tcc aga cat aat gct ccc ccg acc acg ctg ccc cag ccg gcc act aaa     4272
 Ser Arg His Asn Ala Pro Pro Thr Thr Leu Pro Gln Pro Ala Thr Lys
    1410                1415                1420

 cca tct aaa gag atg agc ggg tcg aat gag acc tcg agc cca gtc tca     4320
 Pro Ser Lys Glu Met Ser Gly Ser Asn Glu Thr Ser Ser Pro Val Ser
1425                1430                1435                1440

 gaa aag ccc tcg gct tcc aga acc tct atc cct gta ttg act tcc ttt     4368
 Glu Lys Pro Ser Ala Ser Arg Thr Ser Ile Pro Val Leu Thr Ser Phe
                1445                1450                1455

 ggg gca agg aat tct tcc atc tcc ttc tag                             4398
 Gly Ala Arg Asn Ser Ser Ile Ser Phe 
            1460                1465





      <210> 635
      <211> 1986
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (1)..(1986)

      <400> 635
  atg tgg ccc ctg tgg cgc ctc gtg tct ctg ctg gcc ctg agc cag gcc      48
  Met Trp Pro Leu Trp Arg Leu Val Ser Leu Leu Ala Leu Ser Gln Ala
    1               5                  10                  15

 ctg ccc ttt gag cag aga ggc ttc tgg gac ttc acc ctg gac gat ggg       96
 Leu Pro Phe Glu Gln Arg Gly Phe Trp Asp Phe Thr Leu Asp Asp Gly
              20                  25                  30

 cca ttc atg atg aac gat gag gaa gct tcg ggc gct gac acc tcg ggc      144
 Pro Phe Met Met Asn Asp Glu Glu Ala Ser Gly Ala Asp Thr Ser Gly
          35                  40                  45

 gtc ctg gac ccg gac tct gtc aca ccc acc tac agc gcc atg tgt cct      192
 Val Leu Asp Pro Asp Ser Val Thr Pro Thr Tyr Ser Ala Met Cys Pro
      50                  55                  60

 ttc ggc tgc cac tgc cac ctg cgg gtg gtt cag tgc tcc gac ctg ggt      240
 Phe Gly Cys His Cys His Leu Arg Val Val Gln Cys Ser Asp Leu Gly
  65                  70                  75                  80

 ttg tcc ctg agt gat ggg gag cgg ggc atg cag gga ggc tca ggt ctc      288
 Leu Ser Leu Ser Asp Gly Glu Arg Gly Met Gln Gly Gly Ser Gly Leu
                  85                  90                  95

 gag ttc atg ctg gtg gtg ggg gtg ggg ccc cta ggt ctc aag ttc atg      336
 Glu Phe Met Leu Val Val Gly Val Gly Pro Leu Gly Leu Lys Phe Met
             100                 105                 110

 ctg gtg atg ggg gtg ggg ccc cta ggt ctg aag tct gtg ccc aaa gag      384
 Leu Val Met Gly Val Gly Pro Leu Gly Leu Lys Ser Val Pro Lys Glu
         115                 120                 125

 atc tcc cct gac acc acg ctg ctg gac ctg cag aac aac gac atc tcc      432
 Ile Ser Pro Asp Thr Thr Leu Leu Asp Leu Gln Asn Asn Asp Ile Ser
     130                 135                 140

 gag ctc cgc aag gat gac ttc aag ggt ctc cag cac ctc tac gcc ctc      480
 Glu Leu Arg Lys Asp Asp Phe Lys Gly Leu Gln His Leu Tyr Ala Leu
 145                 150                 155                 160

 gtc ctg gtg aac aac aag atc tcc aag atc cat gag aag gcc ttc agc      528
 Val Leu Val Asn Asn Lys Ile Ser Lys Ile His Glu Lys Ala Phe Ser
                 165                 170                 175

 cca ctg cgg aag ctg cag aag ctc tac atc tcc aag aac cac ctg gtg      576
 Pro Leu Arg Lys Leu Gln Lys Leu Tyr Ile Ser Lys Asn His Leu Val
             180                 185                 190

 gag atc ccg ccc aac cta ccc agc tcc ctg gtg gag ctc cgc atc cac      624
 Glu Ile Pro Pro Asn Leu Pro Ser Ser Leu Val Glu Leu Arg Ile His
         195                 200                 205

 gac aac cgc atc cgc aag gtg ccc aag gga gtg ttc agt ggg ctc cgg      672
 Asp Asn Arg Ile Arg Lys Val Pro Lys Gly Val Phe Ser Gly Leu Arg
     210                 215                 220

 aac atg aac tgc atc gag atg ggc ggg aac cca ctg gag aac agt ggc      720
 Asn Met Asn Cys Ile Glu Met Gly Gly Asn Pro Leu Glu Asn Ser Gly
 225                 230                 235                 240

 ttt gaa cct gga gcc ttc gat ggc ctg aag ctc aac tac ctg cgc atc      768
 Phe Glu Pro Gly Ala Phe Asp Gly Leu Lys Leu Asn Tyr Leu Arg Ile
                 245                 250                 255

 tca gag gcc aag ctg act ggc atc ccc aaa gac ctc cct gag acc ctg      816
 Ser Glu Ala Lys Leu Thr Gly Ile Pro Lys Asp Leu Pro Glu Thr Leu
             260                 265                 270

 aat gaa ctc cac cta gac cac aac aaa atc cag gcc atc gaa ctg gag      864
 Asn Glu Leu His Leu Asp His Asn Lys Ile Gln Ala Ile Glu Leu Glu
         275                 280                 285

 gac ctg ctt cgc tac tcc aag ctg tac agg ctg ggc cta ggc cac aac      912
 Asp Leu Leu Arg Tyr Ser Lys Leu Tyr Arg Leu Gly Leu Gly His Asn
     290                 295                 300

 cag atc agg atg atc gag aac ggg agc ctg agc ttc ctg ccc acc ctc      960
 Gln Ile Arg Met Ile Glu Asn Gly Ser Leu Ser Phe Leu Pro Thr Leu
 305                 310                 315                 320

 cgg gag ctc cac ttg gac aac aac aag ttg gcc agg gtg ccc tca ggg     1008
 Arg Glu Leu His Leu Asp Asn Asn Lys Leu Ala Arg Val Pro Ser Gly
                 325                 330                 335

 ctc cca gac ctc aag ctc ctc cag gtg gtc tat ctg cac tcc aac aac     1056
 Leu Pro Asp Leu Lys Leu Leu Gln Val Val Tyr Leu His Ser Asn Asn
             340                 345                 350

 atc acc aaa gtg ggt gtc aac gac ttc tgt ccc atg ggc ttc ggg gtg     1104
 Ile Thr Lys Val Gly Val Asn Asp Phe Cys Pro Met Gly Phe Gly Val
         355                 360                 365

 aag cgg gcc tac tac aac ggc atc agc ctc ttc aac aac ccc gtg ccc     1152
 Lys Arg Ala Tyr Tyr Asn Gly Ile Ser Leu Phe Asn Asn Pro Val Pro
     370                 375                 380

 tac tgg gag gtg cag ccg gcc act ttc cgc tgc gtc act gac cgc ctg     1200
 Tyr Trp Glu Val Gln Pro Ala Thr Phe Arg Cys Val Thr Asp Arg Leu
 385                 390                 395                 400

 gcc atc cag ttt ggc aac tac aaa aat gtg aag atg aat cac ata gcc     1248
 Ala Ile Gln Phe Gly Asn Tyr Lys Asn Val Lys Met Asn His Ile Ala
                 405                 410                 415

 tca ctc tac cgc caa gtg tgg gaa aaa cta tta gct aat act agc caa     1296
 Ser Leu Tyr Arg Gln Val Trp Glu Lys Leu Leu Ala Asn Thr Ser Gln
             420                 425                 430

 ggc aag aaa gaa ttt gag gct gcg tcc agg cct ctt gca cct gcc tca     1344
 Gly Lys Lys Glu Phe Glu Ala Ala Ser Arg Pro Leu Ala Pro Ala Ser
         435                 440                 445

 ggc tcc cgc cca gag cct cta cct gtg ccc cag cga gca ttc tct gct     1392
 Gly Ser Arg Pro Glu Pro Leu Pro Val Pro Gln Arg Ala Phe Ser Ala
     450                 455                 460

 cgc tgc tca gaa tgc tcg caa agg ccg gcc ctg ggg tca gag gcc tcc     1440
 Arg Cys Ser Glu Cys Ser Gln Arg Pro Ala Leu Gly Ser Glu Ala Ser
 465                 470                 475                 480

 aca gcc cct gga gct ggg aag cct ggg ggt cca ccg gca ggc acg ggg     1488
 Thr Ala Pro Gly Ala Gly Lys Pro Gly Gly Pro Pro Ala Gly Thr Gly
                 485                 490                 495

 gtc tct ttc cag gcc ttt cca tcc ttg gag cgg atc gtt gcc cgc ctg     1536
 Val Ser Phe Gln Ala Phe Pro Ser Leu Glu Arg Ile Val Ala Arg Leu
             500                 505                 510

 acg ccc gcc cgc agc gac agc gcc cgc cgg agc cga ggc cgc ggc ggc     1584
 Thr Pro Ala Arg Ser Asp Ser Ala Arg Arg Ser Arg Gly Arg Gly Gly
         515                 520                 525

 ggc cgt gcc cat gcc cgg gaa cgg ctg tct ccc cct cct cgc ctg tgt     1632
 Gly Arg Ala His Ala Arg Glu Arg Leu Ser Pro Pro Pro Arg Leu Cys
     530                 535                 540

 gac ctt ggc cag cca gct ttt cct gtg gcc gcc tgc gtt ttc tca cgg     1680
 Asp Leu Gly Gln Pro Ala Phe Pro Val Ala Ala Cys Val Phe Ser Arg
 545                 550                 555                 560

 gtg aaa gct ctg gct tta aga ttc tgg aat ttg gaa tgg cag aat ggc     1728
 Val Lys Ala Leu Ala Leu Arg Phe Trp Asn Leu Glu Trp Gln Asn Gly
                 565                 570                 575

 gcc agc tat gcc agg ggg cca cat ctt att gat gtg atg ggc atg agg     1776
 Ala Ser Tyr Ala Arg Gly Pro His Leu Ile Asp Val Met Gly Met Arg
             580                 585                 590

 gac act gcc ctg gtt cac tgt gtg cca ggc tct gtg ttt gct tca ggg     1824
 Asp Thr Ala Leu Val His Cys Val Pro Gly Ser Val Phe Ala Ser Gly
         595                 600                 605

 gag acg acg gaa agc aaa aag caa acg caa tgc cct tcc tgc cct cct     1872
 Glu Thr Thr Glu Ser Lys Lys Gln Thr Gln Cys Pro Ser Cys Pro Pro
     610                 615                 620

 gga gcc ttt gtg ctt tgc tca gtg ttc acc aaa att tca cag ctc tcc     1920
 Gly Ala Phe Val Leu Cys Ser Val Phe Thr Lys Ile Ser Gln Leu Ser
 625                 630                 635                 640

 tat gag gcc ctc aca gga gtg gaa tcc tac agt gtt ggc ctc tct gtg     1968
 Tyr Glu Ala Leu Thr Gly Val Glu Ser Tyr Ser Val Gly Leu Ser Val
                 645                 650                 655

 act ggc tcc ttc tac tga                                             1986
 Thr Gly Ser Phe Tyr 
             660





      <210> 636
      <211> 2202
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (1)..(2202)

      <400> 636
  atg gcc gca tgg ccc cga atc tcc ctc gct ggc ccc gtc tct gtg gct      48
  Met Ala Ala Trp Pro Arg Ile Ser Leu Ala Gly Pro Val Ser Val Ala
    1               5                  10                  15

 cag tct ctg ctg gct cca gag cgt ggc ctg gcc tgc gcg tca gtg gac       96
 Gln Ser Leu Leu Ala Pro Glu Arg Gly Leu Ala Cys Ala Ser Val Asp
              20                  25                  30

 gtc tgt tcc cgt gtg ggg gtg ttc ttg tgg gcg gga agc acg gct gat      144
 Val Cys Ser Arg Val Gly Val Phe Leu Trp Ala Gly Ser Thr Ala Asp
          35                  40                  45

 gct ccg aag gag gga aga ctg acc cgg ttt ctg gac ttc acc cag ctg      192
 Ala Pro Lys Glu Gly Arg Leu Thr Arg Phe Leu Asp Phe Thr Gln Leu
      50                  55                  60

 atg gac atg gca tct gaa tcc gta gga gga aaa ctt gct gga gag cag      240
 Met Asp Met Ala Ser Glu Ser Val Gly Gly Lys Leu Ala Gly Glu Gln
  65                  70                  75                  80

 ctg gcg ggc agg gat gag gtg cag ggt ggt tct ggc aga ggt gtc tgc      288
 Leu Ala Gly Arg Asp Glu Val Gln Gly Gly Ser Gly Arg Gly Val Cys
                  85                  90                  95

 gag gag agc aag gga gcc cac atg ctc cag gtg gct cag tgt ttc aag      336
 Glu Glu Ser Lys Gly Ala His Met Leu Gln Val Ala Gln Cys Phe Lys
             100                 105                 110

 aac acg ctg cgc gtt tgt gag aag agt tgg gag cac gag tct gga gag      384
 Asn Thr Leu Arg Val Cys Glu Lys Ser Trp Glu His Glu Ser Gly Glu
         115                 120                 125

 agt gac agc ccg tgc ttc aaa gag cat gaa tat acg gag ttt ggg aaa      432
 Ser Asp Ser Pro Cys Phe Lys Glu His Glu Tyr Thr Glu Phe Gly Lys
     130                 135                 140

 tgg atg gat ggc tgg gag acc agg agg aaa agg att cca ggt cac gac      480
 Trp Met Asp Gly Trp Glu Thr Arg Arg Lys Arg Ile Pro Gly His Asp
 145                 150                 155                 160

 tgg tgt gtc ctc agg ctg ggg atc caa gga gtc atc cgg ggc ttc gac      528
 Trp Cys Val Leu Arg Leu Gly Ile Gln Gly Val Ile Arg Gly Phe Asp
                 165                 170                 175

 gtg gac gtt tct tac ttc acg gga gat tac gct cct cga gtg tcc att      576
 Val Asp Val Ser Tyr Phe Thr Gly Asp Tyr Ala Pro Arg Val Ser Ile
             180                 185                 190

 caa gca gca aac ttg gaa gaa gat aaa cta cca gaa atc cca gaa aga      624
 Gln Ala Ala Asn Leu Glu Glu Asp Lys Leu Pro Glu Ile Pro Glu Arg
         195                 200                 205

 gga acc agg aca gga gct gca gcc act cct gag gag ttt gaa gcc att      672
 Gly Thr Arg Thr Gly Ala Ala Ala Thr Pro Glu Glu Phe Glu Ala Ile
     210                 215                 220

 gct gag cta aaa tcc gac gac tgg agt tac ttg gtt ccc atg act gag      720
 Ala Glu Leu Lys Ser Asp Asp Trp Ser Tyr Leu Val Pro Met Thr Glu
 225                 230                 235                 240

 ctt aag cca gga aac cct gct tcc ggc cac aac tat ttt ctt gtc aat      768
 Leu Lys Pro Gly Asn Pro Ala Ser Gly His Asn Tyr Phe Leu Val Asn
                 245                 250                 255

 tcc cag cag aga tgg act cat atc aga ctc aac att ttc cca gat aat      816
 Ser Gln Gln Arg Trp Thr His Ile Arg Leu Asn Ile Phe Pro Asp Asn
             260                 265                 270

 gat ggg att tcc att gat gtc agt ctt ctc att ctg agc ctt gat gat      864
 Asp Gly Ile Ser Ile Asp Val Ser Leu Leu Ile Leu Ser Leu Asp Asp
         275                 280                 285

 act gtg gaa ctt gcc atg ggt gga agc cta ctg gaa cat gta ggc cag      912
 Thr Val Glu Leu Ala Met Gly Gly Ser Leu Leu Glu His Val Gly Gln
     290                 295                 300

 gta gtt gag gtc aat gaa ggc atc att gat gat gac aat atc cac ttt      960
 Val Val Glu Val Asn Glu Gly Ile Ile Asp Asp Asp Asn Ile His Phe
 305                 310                 315                 320

 gcc aga gct aaa agc agc ctt ggt gac cag aga cga tac aag agt ggt     1008
 Ala Arg Ala Lys Ser Ser Leu Gly Asp Gln Arg Arg Tyr Lys Ser Gly
                 325                 330                 335

 aca gaa gtg aac aac aca gat ggt gga att gca cga ctt aga gta ttc     1056
 Thr Glu Val Asn Asn Thr Asp Gly Gly Ile Ala Arg Leu Arg Val Phe
             340                 345                 350

 ggt act gga caa aaa gac tgg act gca act gac ccc aaa gaa cct gca     1104
 Gly Thr Gly Gln Lys Asp Trp Thr Ala Thr Asp Pro Lys Glu Pro Ala
         355                 360                 365

 gac cta gtg gcc atc gct ttt ggg ggt gtc tgt gta gga ttt agt aat     1152
 Asp Leu Val Ala Ile Ala Phe Gly Gly Val Cys Val Gly Phe Ser Asn
     370                 375                 380

 gct aag ttt ggg cac cca aac aat ata ata ggc aat gct cct gac agc     1200
 Ala Lys Phe Gly His Pro Asn Asn Ile Ile Gly Asn Ala Pro Asp Ser
 385                 390                 395                 400

 tgt aaa gtg gat ggg tgc atc ctg aca act cag gaa gaa gaa gcc gtg     1248
 Cys Lys Val Asp Gly Cys Ile Leu Thr Thr Gln Glu Glu Glu Ala Val
                 405                 410                 415

 atc agg caa aag tgg att ctc ccg gcc cac aag tgg aaa cca ctg ctt     1296
 Ile Arg Gln Lys Trp Ile Leu Pro Ala His Lys Trp Lys Pro Leu Leu
             420                 425                 430

 cca gtg acc aag ttg tct ccc aac caa agt cat ctg ttc gat agc ctg     1344
 Pro Val Thr Lys Leu Ser Pro Asn Gln Ser His Leu Phe Asp Ser Leu
         435                 440                 445

 acc cta gag ctc caa gat gtc atc act cac gcc agg ctc acc atc gtc     1392
 Thr Leu Glu Leu Gln Asp Val Ile Thr His Ala Arg Leu Thr Ile Val
     450                 455                 460

 ccc gac ggg gga gtg agc cgc ctt cgg ctc cgg ggc ttc ccc agc tcc     1440
 Pro Asp Gly Gly Val Ser Arg Leu Arg Leu Arg Gly Phe Pro Ser Ser
 465                 470                 475                 480

 atc tgc ctc ctg agg ccc cgg gag aag ccc atg ttg aag ttc tcg ccc     1488
 Ile Cys Leu Leu Arg Pro Arg Glu Lys Pro Met Leu Lys Phe Ser Pro
                 485                 490                 495

 ctc gcc ctg gcg gcc agg cgg tca caa tcg ccc agg gtc gcg tca aca     1536
 Leu Ala Leu Ala Ala Arg Arg Ser Gln Ser Pro Arg Val Ala Ser Thr
             500                 505                 510

 cgc agc ctc cgc ccg cct ggc agc ccc gtc ccg tcc ccg tcc agc ccc     1584
 Arg Ser Leu Arg Pro Pro Gly Ser Pro Val Pro Ser Pro Ser Ser Pro
         515                 520                 525

 cgt ccc gtc ccc gtc ccg tcc ccg tcc tgc gcc agc ggc tgg agc gga     1632
 Arg Pro Val Pro Val Pro Ser Pro Ser Cys Ala Ser Gly Trp Ser Gly
     530                 535                 540

 cct ccc gtc ggc ggt gcc cgg gcc tgg gcg cgg ctc tgc agg cgt cgc     1680
 Pro Pro Val Gly Gly Ala Arg Ala Trp Ala Arg Leu Cys Arg Arg Arg
 545                 550                 555                 560

 tgc ccg cgc tgc cgc agc ctc tcg gcc ccg gcg agc gag gag cgg ggc     1728
 Cys Pro Arg Cys Arg Ser Leu Ser Ala Pro Ala Ser Glu Glu Arg Gly
                 565                 570                 575

 gcg gct atg gga acc cgc ggg ccc tcc gcg ccg gtg gac acc acg ccc     1776
 Ala Ala Met Gly Thr Arg Gly Pro Ser Ala Pro Val Asp Thr Thr Pro
             580                 585                 590

 gcc aag acc atc gtg gtg tac cgc aac ggg gac ccg ttc tac gtg ggc     1824
 Ala Lys Thr Ile Val Val Tyr Arg Asn Gly Asp Pro Phe Tyr Val Gly
         595                 600                 605

 aag aag ttc gtg ctg tcg cgg cgc cgc gcg gcc acc ttc gag gcg ctg     1872
 Lys Lys Phe Val Leu Ser Arg Arg Arg Ala Ala Thr Phe Glu Ala Leu
     610                 615                 620

 ctg gag cag ctc acg gag cag gtg gac gtc ccg ttc ggc gtg cgc cgc     1920
 Leu Glu Gln Leu Thr Glu Gln Val Asp Val Pro Phe Gly Val Arg Arg
 625                 630                 635                 640

 ctc ttc acg ccc acg cgt ggg cac cgg gtg ctg ggg ctg gac gcg ctg     1968
 Leu Phe Thr Pro Thr Arg Gly His Arg Val Leu Gly Leu Asp Ala Leu
                 645                 650                 655

 cag gcg ggc ggc aag tac gtg gcg gcg ggc cgc gag cgc ttc aag gag     2016
 Gln Ala Gly Gly Lys Tyr Val Ala Ala Gly Arg Glu Arg Phe Lys Glu
             660                 665                 670

 ctc gat tat att cat ata gtt ccc cga aaa cct gca aag ata agg aag     2064
 Leu Asp Tyr Ile His Ile Val Pro Arg Lys Pro Ala Lys Ile Arg Lys
         675                 680                 685

 ttg aag gaa aag cgg ctc ttc tct gtg tct ttg gag cat cac cca gag     2112
 Leu Lys Glu Lys Arg Leu Phe Ser Val Ser Leu Glu His His Pro Glu
     690                 695                 700

 ctc cat gca gga cac gcc agc agc ccc agc att gtt cac agg cac cag     2160
 Leu His Ala Gly His Ala Ser Ser Pro Ser Ile Val His Arg His Gln
 705                 710                 715                 720

 ctt cca gaa gcg ttc cgc tgc ctt ctt gga gtc tgc cct tga             2202
 Leu Pro Glu Ala Phe Arg Cys Leu Leu Gly Val Cys Pro 
                 725                 730





      <210> 637
      <211> 561
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (1)..(561)

      <400> 637
  atg cca ctc aat ctg ggg agt ggc tat ttt ggg gtc ctg tgt ata ttt      48
  Met Pro Leu Asn Leu Gly Ser Gly Tyr Phe Gly Val Leu Cys Ile Phe
    1               5                  10                  15

 gag ctt atg ttt tac acg aag aac ctt gta aat ggg agc aac tcc tcc       96
 Glu Leu Met Phe Tyr Thr Lys Asn Leu Val Asn Gly Ser Asn Ser Ser
              20                  25                  30

 aga agg gtc agc agc ata tca gta acc ccc gct ttt aaa cct ttc aac      144
 Arg Arg Val Ser Ser Ile Ser Val Thr Pro Ala Phe Lys Pro Phe Asn
          35                  40                  45

 gtg att gcc cta gag ttt gca ata cac att tac aag gaa tcg aat cct      192
 Val Ile Ala Leu Glu Phe Ala Ile His Ile Tyr Lys Glu Ser Asn Pro
      50                  55                  60

 act ttc aaa gaa cat tat acc act tca cat gta gta gaa aac ctc agg      240
 Thr Phe Lys Glu His Tyr Thr Thr Ser His Val Val Glu Asn Leu Arg
  65                  70                  75                  80

 aaa ttc tac aag ggc aag aag tac cag ccc gtg gac ctg cag cct aag      288
 Lys Phe Tyr Lys Gly Lys Lys Tyr Gln Pro Val Asp Leu Gln Pro Lys
                  85                  90                  95

 aag aca tgc gcc atg agc cac tgt ctc aac aag cac gag gag aac ctg      336
 Lys Thr Cys Ala Met Ser His Cys Leu Asn Lys His Glu Glu Asn Leu
             100                 105                 110

 aag ggc aag aag cag cag tgg aag gag tgg ctg tcc ccg ctg agg aag      384
 Lys Gly Lys Lys Gln Gln Trp Lys Glu Trp Leu Ser Pro Leu Arg Lys
         115                 120                 125

 gag gaa gga gcg cct gtc cct gct gag gaa gta cac gtc agt gag gcc      432
 Glu Glu Gly Ala Pro Val Pro Ala Glu Glu Val His Val Ser Glu Ala
     130                 135                 140

 cct cca ccg gcc cca gct ttc aca acg aac aag tgg tgg gtc aag gaa      480
 Pro Pro Pro Ala Pro Ala Phe Thr Thr Asn Lys Trp Trp Val Lys Glu
 145                 150                 155                 160

 tcc aag acc tac atc ttt ggc cac aga gtc aag gag gcc agt tac caa      528
 Ser Lys Thr Tyr Ile Phe Gly His Arg Val Lys Glu Ala Ser Tyr Gln
                 165                 170                 175

 ttg tgg atg aat gag acc cgt ggg gcc tgc tga                          561
 Leu Trp Met Asn Glu Thr Arg Gly Ala Cys 
             180                 185





      <210> 638
      <211> 306
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (1)..(306)

      <400> 638
  atg ggc ttt gaa ctc ttg tct gtc tta ctt cca agg tct ttc tgc cag      48
  Met Gly Phe Glu Leu Leu Ser Val Leu Leu Pro Arg Ser Phe Cys Gln
    1               5                  10                  15

 ctg cag acc ttc aag gac tct gtc ttt ggt ctg gaa aat cga agc cca       96
 Leu Gln Thr Phe Lys Asp Ser Val Phe Gly Leu Glu Asn Arg Ser Pro
              20                  25                  30

 aag gat gtc atg ttt cag gca tct ccc tac cca agt gat cag cag ctg      144
 Lys Asp Val Met Phe Gln Ala Ser Pro Tyr Pro Ser Asp Gln Gln Leu
          35                  40                  45

 gac tgt gcc ttg gac cta atg agg cgc ctg cct ccc cag caa atc gag      192
 Asp Cys Ala Leu Asp Leu Met Arg Arg Leu Pro Pro Gln Gln Ile Glu
      50                  55                  60

 aaa aac ctc agc gac ctg atc gac ctg gtc acc aga gga tgg ctg act      240
 Lys Asn Leu Ser Asp Leu Ile Asp Leu Val Thr Arg Gly Trp Leu Thr
  65                  70                  75                  80

 ctg aat gca gct gtc ttc aca att ctt agc acc ggc aag aag tta ctc      288
 Leu Asn Ala Ala Val Phe Thr Ile Leu Ser Thr Gly Lys Lys Leu Leu
                  85                  90                  95

 agt ctc cgt agt ggg tag                                              306
 Ser Leu Arg Ser Gly 
             100





      <210> 639
      <211> 432
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (1)..(432)

      <400> 639
  atg tct tct ctg ggg tct tca ttt ctt tat gct ctg tcc ctc ttt gca      48
  Met Ser Ser Leu Gly Ser Ser Phe Leu Tyr Ala Leu Ser Leu Phe Ala
    1               5                  10                  15

 gag tcc tcg aat gcc acc ttg ctg acc aat gca gag aag att gcc acc       96
 Glu Ser Ser Asn Ala Thr Leu Leu Thr Asn Ala Glu Lys Ile Ala Thr
              20                  25                  30

 atc acc acc aca cac acc cct tct cag caa ggg acc cag gag aca agg      144
 Ile Thr Thr Thr His Thr Pro Ser Gln Gln Gly Thr Gln Glu Thr Arg
          35                  40                  45

 aat acc acc aaa cca aag cag gaa tct caa ttt gag ttc aaa gca ccc      192
 Asn Thr Thr Lys Pro Lys Gln Glu Ser Gln Phe Glu Phe Lys Ala Pro
      50                  55                  60

 caa gca aca cag gag caa gat ttt tac act gtg gaa ctg gaa aga gga      240
 Gln Ala Thr Gln Glu Gln Asp Phe Tyr Thr Val Glu Leu Glu Arg Gly
  65                  70                  75                  80

 gcc aag gga ttt ggc ttt agc ctt cga gga ggc cga gag tat aac atg      288
 Ala Lys Gly Phe Gly Phe Ser Leu Arg Gly Gly Arg Glu Tyr Asn Met
                  85                  90                  95

 gac ctc tat gtt ctg cgc tta gca gag gac ggt cct gcg gag agg tgt      336
 Asp Leu Tyr Val Leu Arg Leu Ala Glu Asp Gly Pro Ala Glu Arg Cys
             100                 105                 110

 gga aag atg agg ctg gtt acc agt ggt ctt acc tta ggc tca gag aca      384
 Gly Lys Met Arg Leu Val Thr Ser Gly Leu Thr Leu Gly Ser Glu Thr
         115                 120                 125

 gca agt cta ctc tct gcc tta gca aag agc cag ggc tct gtg gca tga      432
 Ala Ser Leu Leu Ser Ala Leu Ala Lys Ser Gln Gly Ser Val Ala 
     130                 135                 140





      <210> 640
      <211> 1856
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (63)..(1856)

      <400> 640
 tcatttgttt gggccatgac aaaggaccac agactgggag gcttacacgg ccgaaattga     60

 ta   atg tcc aac acc aag ctg cta gca ggt ggc tcc ttc tcc atg gct     107
      Met Ser Asn Thr Lys Leu Leu Ala Gly Gly Ser Phe Ser Met Ala
        1               5                  10                  15

 tct tgg tgg ccg ttg ctt cct gta tct ctt ctc aag acg gct tcc ctc      155
 Ser Trp Trp Pro Leu Leu Pro Val Ser Leu Leu Lys Thr Ala Ser Leu
                  20                  25                  30

 tat gtg tct atg tct atg tgt ccc cct atc gtc tcg acc cag gag aag      203
 Tyr Val Ser Met Ser Met Cys Pro Pro Ile Val Ser Thr Gln Glu Lys
              35                  40                  45

 gag ctg gtg cag ccc ttc agc tcg ctg ttc ccg aag gtg gag tac atc      251
 Glu Leu Val Gln Pro Phe Ser Ser Leu Phe Pro Lys Val Glu Tyr Ile
          50                  55                  60

 gcc agg gcc ggg tgg acc cgg gat ggc aaa tac gcc tgg gcc atg ttc      299
 Ala Arg Ala Gly Trp Thr Arg Asp Gly Lys Tyr Ala Trp Ala Met Phe
      65                  70                  75

 ctg gac cgg ccc cag cag tgg ctc cag ctc gtc ctc ctc ccc ccg gcc      347
 Leu Asp Arg Pro Gln Gln Trp Leu Gln Leu Val Leu Leu Pro Pro Ala
  80                  85                  90                  95

 ctg ttc atc ccg agc aca gag aat gag gag cag cgg cta gcc tct gcc      395
 Leu Phe Ile Pro Ser Thr Glu Asn Glu Glu Gln Arg Leu Ala Ser Ala
                 100                 105                 110

 aga gct gtc ccc agg aat gtc cag ccg tat gtg gtg tac gag gag gtc      443
 Arg Ala Val Pro Arg Asn Val Gln Pro Tyr Val Val Tyr Glu Glu Val
             115                 120                 125

 acc aac gtc tgg atc aat gtt cat gac atc ttc tat ccc ttc ccc caa      491
 Thr Asn Val Trp Ile Asn Val His Asp Ile Phe Tyr Pro Phe Pro Gln
         130                 135                 140

 tca gag gga gag gac gag ctc tgc ttt ctc cgc gcc aat gaa tgc aag      539
 Ser Glu Gly Glu Asp Glu Leu Cys Phe Leu Arg Ala Asn Glu Cys Lys
     145                 150                 155

 acc ggc ttc tgc cat ttg tac aaa gtc acc gcc gtt tta aaa tcc cag      587
 Thr Gly Phe Cys His Leu Tyr Lys Val Thr Ala Val Leu Lys Ser Gln
 160                 165                 170                 175

 ggc tac gat tgg agt gag ccc ttc agc ccc ggg gaa gat gaa ttt aag      635
 Gly Tyr Asp Trp Ser Glu Pro Phe Ser Pro Gly Glu Asp Glu Phe Lys
                 180                 185                 190

 tgc ccc att aag gaa gag att gct ctg acc agc ggt gaa tgg gag gtt      683
 Cys Pro Ile Lys Glu Glu Ile Ala Leu Thr Ser Gly Glu Trp Glu Val
             195                 200                 205

 ttg gcg agg cac ggc tcc aag gca tca gcc aaa gcc tgc tcg ctc ctg      731
 Leu Ala Arg His Gly Ser Lys Ala Ser Ala Lys Ala Cys Ser Leu Leu
         210                 215                 220

 ggc agc agc agt tgt ttc gag acc att agc atc cca gca cag atc tgg      779
 Gly Ser Ser Ser Cys Phe Glu Thr Ile Ser Ile Pro Ala Gln Ile Trp
     225                 230                 235

 gtc aat gag gag acc aag ctg gtg tac ttc cag ggc acc aag gac acg      827
 Val Asn Glu Glu Thr Lys Leu Val Tyr Phe Gln Gly Thr Lys Asp Thr
 240                 245                 250                 255

 ccg ctg gag cac cac ctc tac gtg gtc agc tat gag gcg gcc ggc gag      875
 Pro Leu Glu His His Leu Tyr Val Val Ser Tyr Glu Ala Ala Gly Glu
                 260                 265                 270

 atc gta cgc ctc acc acg ccc ggc ttc tcc cat agc tgc tcc atg agc      923
 Ile Val Arg Leu Thr Thr Pro Gly Phe Ser His Ser Cys Ser Met Ser
             275                 280                 285

 cag aac ttc gac atg ttc gtc agc cac tac agc agc gtg agc acg ccg      971
 Gln Asn Phe Asp Met Phe Val Ser His Tyr Ser Ser Val Ser Thr Pro
         290                 295                 300

 ccc tgc gtg cac gtc tac aag ctg agc ggc ccc gac gac gac ccc ctg     1019
 Pro Cys Val His Val Tyr Lys Leu Ser Gly Pro Asp Asp Asp Pro Leu
     305                 310                 315

 cac aag cag ccc cgc ttc tgg gct agc atg atg gag gca gcc agc tgc     1067
 His Lys Gln Pro Arg Phe Trp Ala Ser Met Met Glu Ala Ala Ser Cys
 320                 325                 330                 335

 ccc ccg gat tat gtt cct cca gag atc ttc cat ttc cac acg cgc tcg     1115
 Pro Pro Asp Tyr Val Pro Pro Glu Ile Phe His Phe His Thr Arg Ser
                 340                 345                 350

 gat gtg cgg ctc tac ggc atg atc tac aag ccc cac gcc ttg cag cca     1163
 Asp Val Arg Leu Tyr Gly Met Ile Tyr Lys Pro His Ala Leu Gln Pro
             355                 360                 365

 ggg aag aag cac ccc acc gtc ctc ttt gta tat gga ggc ccc cag gtg     1211
 Gly Lys Lys His Pro Thr Val Leu Phe Val Tyr Gly Gly Pro Gln Val
         370                 375                 380

 cag ctg gtg aat aac tcc ttc aaa ggc atc aag tac ttg cgg ctc aac     1259
 Gln Leu Val Asn Asn Ser Phe Lys Gly Ile Lys Tyr Leu Arg Leu Asn
     385                 390                 395

 aca ctg gcc tcc ctg ggc tac gcc gtg gtt gtg att gac ggc agg ggc     1307
 Thr Leu Ala Ser Leu Gly Tyr Ala Val Val Val Ile Asp Gly Arg Gly
 400                 405                 410                 415

 tcc tgt cag cga ggg ctt cgg ttc gaa ggg gcc ctg aaa aac caa atg     1355
 Ser Cys Gln Arg Gly Leu Arg Phe Glu Gly Ala Leu Lys Asn Gln Met
                 420                 425                 430

 ggc cag gtg gag atc gag gac cag gtg gag ggc ctg cag ttc gtg gcc     1403
 Gly Gln Val Glu Ile Glu Asp Gln Val Glu Gly Leu Gln Phe Val Ala
             435                 440                 445

 gag aag tat ggc ttc atc gac ctg agc cga gtt gcc atc cat ggc tgg     1451
 Glu Lys Tyr Gly Phe Ile Asp Leu Ser Arg Val Ala Ile His Gly Trp
         450                 455                 460

 tcc tac ggg ggc ttc ctc tcg ctc atg ggg cta atc cac aag ccc cag     1499
 Ser Tyr Gly Gly Phe Leu Ser Leu Met Gly Leu Ile His Lys Pro Gln
     465                 470                 475

 gtg ttc aag gtg gcc atc gcg ggt gcc ccg gtc acc gtc tgg atg gcc     1547
 Val Phe Lys Val Ala Ile Ala Gly Ala Pro Val Thr Val Trp Met Ala
 480                 485                 490                 495

 tac gac aca ggg tac act gag cgc tac atg gac gtc cct gag aac aac     1595
 Tyr Asp Thr Gly Tyr Thr Glu Arg Tyr Met Asp Val Pro Glu Asn Asn
                 500                 505                 510

 cag cac ggc tat gag gcg ggt tcc gtg gcc ctg cac gtg gag aag ctg     1643
 Gln His Gly Tyr Glu Ala Gly Ser Val Ala Leu His Val Glu Lys Leu
             515                 520                 525

 ccc aat gag ccc aac cgc ttg ctt atc ctc cac ggc ttc ctg gac gaa     1691
 Pro Asn Glu Pro Asn Arg Leu Leu Ile Leu His Gly Phe Leu Asp Glu
         530                 535                 540

 aac gtg cac ttt ttc cac aca aac ttc ctc gtc tcc caa ctg atc cga     1739
 Asn Val His Phe Phe His Thr Asn Phe Leu Val Ser Gln Leu Ile Arg
     545                 550                 555

 gca ggg aaa cct tac cag ctc cag atc tac ccc aac gag aga cac agt     1787
 Ala Gly Lys Pro Tyr Gln Leu Gln Ile Tyr Pro Asn Glu Arg His Ser
 560                 565                 570                 575

 att cgc tgc ccc gag tcg ggc gag cac tat gaa gtc acg ttg ctg cac     1835
 Ile Arg Cys Pro Glu Ser Gly Glu His Tyr Glu Val Thr Leu Leu His
                 580                 585                 590

 ttt cta cag gaa tac ctc tga                                         1856
 Phe Leu Gln Glu Tyr Leu 
             595





      <210> 641
      <211> 873
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (1)..(873)

      <400> 641
  atg tca cat gca ctg gct ctg cta gct tcc acc tgg gct cca act gcc      48
  Met Ser His Ala Leu Ala Leu Leu Ala Ser Thr Trp Ala Pro Thr Ala
    1               5                  10                  15

 aga ccc ccc cag agc ttc aca caa gct atc gct gac tgc cgg tgc atg       96
 Arg Pro Pro Gln Ser Phe Thr Gln Ala Ile Ala Asp Cys Arg Cys Met
              20                  25                  30

 ttg gaa atg ggc cac agg gct ggg cat gat atg agc tgc ctg gac att      144
 Leu Glu Met Gly His Arg Ala Gly His Asp Met Ser Cys Leu Asp Ile
          35                  40                  45

 gga ggg ggc ttc ccc gga atg gag ggc tcc ggg ccc aag ttt gag gag      192
 Gly Gly Gly Phe Pro Gly Met Glu Gly Ser Gly Pro Lys Phe Glu Glu
      50                  55                  60

 gtg agc tgg gat aat tct aat gcc tac ctg cag ggt gcc tcg ggg atg      240
 Val Ser Trp Asp Asn Ser Asn Ala Tyr Leu Gln Gly Ala Ser Gly Met
  65                  70                  75                  80

 aaa gga ctg atg cag ttg gcg aga gtg atc agt gct gcc ctg gcc cag      288
 Lys Gly Leu Met Gln Leu Ala Arg Val Ile Ser Ala Ala Leu Ala Gln
                  85                  90                  95

 gac ctc cct gag gag cgt ggt gtc aag gtc atc gca gag cct ggc tgc      336
 Asp Leu Pro Glu Glu Arg Gly Val Lys Val Ile Ala Glu Pro Gly Cys
             100                 105                 110

 ttc tat gtg gag tct gtc tgc atg gcc gct gtc aac atc att gcc aag      384
 Phe Tyr Val Glu Ser Val Cys Met Ala Ala Val Asn Ile Ile Ala Lys
         115                 120                 125

 agg gct gtg ctg gag ccc gga gtt ctg ctc aga gcc gcc cct ctt ccc      432
 Arg Ala Val Leu Glu Pro Gly Val Leu Leu Arg Ala Ala Pro Leu Pro
     130                 135                 140

 ctg cac cct cta tgt ccc atg tgc gat gcc ttt gac agg ctc ttc ttg      480
 Leu His Pro Leu Cys Pro Met Cys Asp Ala Phe Asp Arg Leu Phe Leu
 145                 150                 155                 160

 gag gat gtg cgg ctg ccc gag ctg gat gta ggc gat tgg ctg gtc ttc      528
 Glu Asp Val Arg Leu Pro Glu Leu Asp Val Gly Asp Trp Leu Val Phe
                 165                 170                 175

 ccc tcc atg ggt gcc tac atg tcc tcc atg agc tcc agc ttc aat ggc      576
 Pro Ser Met Gly Ala Tyr Met Ser Ser Met Ser Ser Ser Phe Asn Gly
             180                 185                 190

 ttc ctg cct gcc acc atc tgc tac acc atg ggc ccc cag ctc agc cag      624
 Phe Leu Pro Ala Thr Ile Cys Tyr Thr Met Gly Pro Gln Leu Ser Gln
         195                 200                 205

 gtc ctc ggg gat ccc aga gtc cct gga gct gaa gag gaa ctt ccc ctg      672
 Val Leu Gly Asp Pro Arg Val Pro Gly Ala Glu Glu Glu Leu Pro Leu
     210                 215                 220

 aca tgt ggg aag caa aga gca gat tgg ggt aac aga ggc cac tca gag      720
 Thr Cys Gly Lys Gln Arg Ala Asp Trp Gly Asn Arg Gly His Ser Glu
 225                 230                 235                 240

 aag cta gag gag ctc aac agc cca tcc agt cag gtg cat ctc atg agg      768
 Lys Leu Glu Glu Leu Asn Ser Pro Ser Ser Gln Val His Leu Met Arg
                 245                 250                 255

 gca tcc cag aac atc aaa ttt ccc gcc tgc aaa atg gtc ttg ctt atg      816
 Ala Ser Gln Asn Ile Lys Phe Pro Ala Cys Lys Met Val Leu Leu Met
             260                 265                 270

 ccc aaa cac tca gaa tat aag aag cac gga tta tgg gta cga tac tta      864
 Pro Lys His Ser Glu Tyr Lys Lys His Gly Leu Trp Val Arg Tyr Leu
         275                 280                 285

 ggg gtg tga                                                          873
 Gly Val 
     290





      <210> 642
      <211> 1773
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (1500)..(1773)

      <400> 642
 atgcagattt gcagggtgag aaactgcatc tctgaggagc cagtcactta tccaaagtgc     60

 atcctgcttg gtgtttctag ctgttaccgt cttctggctg aggaccaatg caaaacccca    120

 gtggtgcctc ttgtcaaggc tagctggtgc tcatgcaggt atgacttagg ttttgcaatg    180

 atgaagccaa agcgccttgg aagcattttc cctgccccgc taactaactt catgccaact    240

 agtctgaagg gttctactcc acagtttcca acagtgcttc ttaagattgg aaaacaaatg    300

 tacggtatct atgtgccaga tgctgtggtg aagaaccagg cttgggcctg gagtgactca    360

 ctcaagatca cacatatagt tagtgacaag gaccctgcta aatgcaagtc tttgtacttc    420

 agaaaaggat tgactgtggc ttactcttgt gggggcaagg gcaacagtga gaatacagtg    480

 caaagcagga tttccaaatt cactgttgtt gctcagaaga gcatctacat acaagttcct    540

 gaggggcaag agttcttcat gatctggaca gcagacccca cacagcagga tctcacagag    600

 cctcaagcac ttgcttcatc ttcacagcaa tgctgcagcc caggtgcacc ttcctcattc    660

 acagaaacag actggctgca gcgagttgga ttcgtgcaga acatctgctg ccagacccat    720

 aatcaactgc aatctcatct cttcccctct ctctactttt atttgattgg attacactac    780

 atcagaaaag agtgcatcag ggatgcgggg aagaatatag ggtctgatga gcaagacaga    840

 aaccaacaag gtcaagaaca caagcagact cagcttaccc tggcaagcaa ggaagaagaa    900

 gaagaaacta gagatgaagg cagtcaattc cagggaggtc atgttctgaa gggggtggac    960

 aaagcagaga agcttaaagg gggatccaag agatcttgca atattgacaa ggcatcccaa   1020

 actaatgcta tgaaagaaaa cattcgcctt gataacgtgt cccaagaaaa actctctgct   1080

 ggtggctcca acttagacaa aggaacaaag ctgctccaag cgtaccccca gagggatgag   1140

 gagctggata cagatgcaga aaaactcctc aaaggatctg tcgtgggtga agaacatcgg   1200

 gtggaagtcg ttgcaggtct cactagctgg aggaaagaga tggaaaataa gagaaaaagt   1260

 tttaaaacag tgaaacacga gaacataacc acaggtctcc cgtactcctc cttcaacata   1320

 aacccagatc atgacctgca gtccaatgtg gatcacagca acaagacggt cacgagcatg   1380

 gccctggagc cagtctgtct gagtttggat cctggcactg ccacttatta tctgtgtgac   1440

 cttgagctca tgagcaagga cagattggta aaaggcaagg ctgaagaaac tggcaggca    1499                                                                 
 tca gtt cgc aca acg ctt tgt aga ctg cat tag gga gaa aga gcc tca     1547
 Met Pro Ala Ser Phe Phe Ser Leu Ala Phe Tyr Gln Ser Val Leu Ala
   1               5                  10                  15

 aaa cca aac caa aac aac caa aca caa cag ata tca cat gga aga ctc     1595
 His Glu Leu Lys Val Thr Gln Ile Ile Ser Gly Ser Ala Arg Ile Gln
              20                  25                  30

 aga gca gcc aac cca cat gaa agt cat ctg taa act gta tcc cat taa     1643
 Thr Gln Thr Asp Trp Leu Gln Gly His Ala Arg Asp Arg Leu Val Ala
          35                  40                  45

 aaa agc taa ttg cta cga aga aaa gac aaa ggg caa ctt tac aca ggc     1691
 Val Ile His Ile Gly Leu Gln Val Met Ile Trp Val Tyr Val Glu Gly
      50                  55                  60

 aca cac atg tgt gca cag agt gga tcc tgt cta tct gta ttc aga tat     1739
 Gly Val Arg Glu Thr Cys Gly Tyr Val Leu Val Phe His Cys Phe Lys
  65                  70                  75                  80

 gct cag cag tat gca gta cct gtt taa cag cta g                       1773
 Thr Phe Ser Leu Ile Phe His Leu Phe Pro Pro Ala Ser Glu Thr Cys 
                  85                  90                  95





      <210> 643
      <211> 1134
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (1)..(1134)

      <400> 643
  atg tcc acg tgg aac tgg ctg agc tgt ttg gca ctc tcc tta acc ctt      48
  Met Ser Thr Trp Asn Trp Leu Ser Cys Leu Ala Leu Ser Leu Thr Leu
    1               5                  10                  15

 gcc cca aag cac act ggt tct gaa cgg ctc tgt ttc gtg atg ttt tgg       96
 Ala Pro Lys His Thr Gly Ser Glu Arg Leu Cys Phe Val Met Phe Trp
              20                  25                  30

 aca ccc aac gtg tct gag aaa atc ttg ata gac atc atc gga gtg gac      144
 Thr Pro Asn Val Ser Glu Lys Ile Leu Ile Asp Ile Ile Gly Val Asp
          35                  40                  45

 ttt gcc ttt gca gaa ctc tgt gtt gtt cct ttg cgg atc ttc tcc ttc      192
 Phe Ala Phe Ala Glu Leu Cys Val Val Pro Leu Arg Ile Phe Ser Phe
      50                  55                  60

 ttc cca gtt cca gtt ccc cgc tgt cca ccc atg gcc ctc ctg cag ctc      240
 Phe Pro Val Pro Val Pro Arg Cys Pro Pro Met Ala Leu Leu Gln Leu
  65                  70                  75                  80

 aga gat cca gtg aag agg cag gca tgg gca ggc cat gca gcc ctt ggt      288
 Arg Asp Pro Val Lys Arg Gln Ala Trp Ala Gly His Ala Ala Leu Gly
                  85                  90                  95

 gaa atg gca gca cac caa cga ggg ccc aca cca tta gga ggg aga aag      336
 Glu Met Ala Ala His Gln Arg Gly Pro Thr Pro Leu Gly Gly Arg Lys
             100                 105                 110

 gga agt gac ctc ggt gga agt ggt cag gac cag tcc agg gaa aga aca      384
 Gly Ser Asp Leu Gly Gly Ser Gly Gln Asp Gln Ser Arg Glu Arg Thr
         115                 120                 125

 gag gga agt ggg gac gag cag ctt cct cct cct acc cca ctg ctt ggt      432
 Glu Gly Ser Gly Asp Glu Gln Leu Pro Pro Pro Thr Pro Leu Leu Gly
     130                 135                 140

 ccc cac acc tct gac cgc agg cag gga aga tgg ctt ctg atg cca gct      480
 Pro His Thr Ser Asp Arg Arg Gln Gly Arg Trp Leu Leu Met Pro Ala
 145                 150                 155                 160

 ttt ctg ctc acg cag cat cac act aga gtg cca ctt ttc tct gag tgt      528
 Phe Leu Leu Thr Gln His His Thr Arg Val Pro Leu Phe Ser Glu Cys
                 165                 170                 175

 tct ctt cta gag gta gat gat cag agg gcg agg ctg gcc aag tgt ggg      576
 Ser Leu Leu Glu Val Asp Asp Gln Arg Ala Arg Leu Ala Lys Cys Gly
             180                 185                 190

 gac agg act gga caa gag cag cta ggc tgc ctg gaa gat gct gtc cca      624
 Asp Arg Thr Gly Gln Glu Gln Leu Gly Cys Leu Glu Asp Ala Val Pro
         195                 200                 205

 gtg gag aaa gga gcc tgc ctg agg cag cag gat ggg gag tgg atg gcg      672
 Val Glu Lys Gly Ala Cys Leu Arg Gln Gln Asp Gly Glu Trp Met Ala
     210                 215                 220

 ggc acg gct gac gag tcc ttt gct cct ccc aac agt cac agt gag ggc      720
 Gly Thr Ala Asp Glu Ser Phe Ala Pro Pro Asn Ser His Ser Glu Gly
 225                 230                 235                 240

 gca tct cac cgg gtg gct gat gac act gaa gaa aac ctt cgt cct tgc      768
 Ala Ser His Arg Val Ala Asp Asp Thr Glu Glu Asn Leu Arg Pro Cys
                 245                 250                 255

 ccc cag ctc tgt gct gcg gat cat cgt cct cat cgc cag cct cgt ggt      816
 Pro Gln Leu Cys Ala Ala Asp His Arg Pro His Arg Gln Pro Arg Gly
             260                 265                 270

 cct acc cta cct ggg aca aat tgc ctt tgt gtt ctc atc tgc agg gtg      864
 Pro Thr Leu Pro Gly Thr Asn Cys Leu Cys Val Leu Ile Cys Arg Val
         275                 280                 285

 cac ggt gcg acc ctg ggc gtg ggc tcc ctc ctg gcg ggc ttt gtg gga      912
 His Gly Ala Thr Leu Gly Val Gly Ser Leu Leu Ala Gly Phe Val Gly
     290                 295                 300

 gaa tcc acc atg gtc gcc atc gct gcg tgc tat gtc tac cgg aag cag      960
 Glu Ser Thr Met Val Ala Ile Ala Ala Cys Tyr Val Tyr Arg Lys Gln
 305                 310                 315                 320

 aca tgc gat gct gcc gat ggg aga ggg gac agt gat acc aat gtg gct     1008
 Thr Cys Asp Ala Ala Asp Gly Arg Gly Asp Ser Asp Thr Asn Val Ala
                 325                 330                 335

 gtg cac aca agg act ggg cag tcc aag aca gga gct cgg gca gcc tct     1056
 Val His Thr Arg Thr Gly Gln Ser Lys Thr Gly Ala Arg Ala Ala Ser
             340                 345                 350

 ctg gtc atg ggc gga gca gag atg cag tcc gag agc ttg cgc aag ggc     1104
 Leu Val Met Gly Gly Ala Glu Met Gln Ser Glu Ser Leu Arg Lys Gly
         355                 360                 365

 ctt tct gat cac ttt tgt ttt tct cag tga                             1134
 Leu Ser Asp His Phe Cys Phe Ser Gln 
     370                 375





      <210> 644
      <211> 2697
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (1)..(2697)

      <400> 644
  atg att aaa atc aga gat tta tcc cca aaa aga caa ttc ctt gct ctg      48
  Met Ile Lys Ile Arg Asp Leu Ser Pro Lys Arg Gln Phe Leu Ala Leu
    1               5                  10                  15

 ctc ttg tgt ttg ttc cct tcc tcc tta tca tct cgt gga agt aag cgg       96
 Leu Leu Cys Leu Phe Pro Ser Ser Leu Ser Ser Arg Gly Ser Lys Arg
              20                  25                  30

 ttg gag aaa aga gaa aaa gga tgc agg gaa agg gaa aac gga tcg gaa      144
 Leu Glu Lys Arg Glu Lys Gly Cys Arg Glu Arg Glu Asn Gly Ser Glu
          35                  40                  45

 aga gct tta att gac tca cag ttc agc atg gat ggg cag gcc gca ggg      192
 Arg Ala Leu Ile Asp Ser Gln Phe Ser Met Asp Gly Gln Ala Ala Gly
      50                  55                  60

 aac tta caa tca cgg tgg aac gag aag ggg aag caa agc acc ttc ttc      240
 Asn Leu Gln Ser Arg Trp Asn Glu Lys Gly Lys Gln Ser Thr Phe Phe
  65                  70                  75                  80

 aca agg cag cag gaa gaa gtg cca agt gaa gcc ggg gaa gag ccc ctt      288
 Thr Arg Gln Gln Glu Glu Val Pro Ser Glu Ala Gly Glu Glu Pro Leu
                  85                  90                  95

 ata aaa cca tca gat ctc tgc agg atc ctg gat ggt ggt ctt aaa cca      336
 Ile Lys Pro Ser Asp Leu Cys Arg Ile Leu Asp Gly Gly Leu Lys Pro
             100                 105                 110

 tca gta tca aaa cca cct ggg aac ctc ata aaa gac cca cgc tcc cgg      384
 Ser Val Ser Lys Pro Pro Gly Asn Leu Ile Lys Asp Pro Arg Ser Arg
         115                 120                 125

 acc ctg tcc cac acc tgt gca atc aga tta ctg agg ctg aga caa gga      432
 Thr Leu Ser His Thr Cys Ala Ile Arg Leu Leu Arg Leu Arg Gln Gly
     130                 135                 140

 tct tcg tgt tta gca agc ttt cca gag aca cta gat cct gtc aca cga      480
 Ser Ser Cys Leu Ala Ser Phe Pro Glu Thr Leu Asp Pro Val Thr Arg
 145                 150                 155                 160

 cgg aat tgg cag tgg tca ccc ttt cca gat aaa cgc atg aat gaa gag      528
 Arg Asn Trp Gln Trp Ser Pro Phe Pro Asp Lys Arg Met Asn Glu Glu
                 165                 170                 175

 gca gtt ttc tct ttt ctt cct cgg tgg tgg ctc tca tgc cct aaa aca      576
 Ala Val Phe Ser Phe Leu Pro Arg Trp Trp Leu Ser Cys Pro Lys Thr
             180                 185                 190

 atg aaa tgt aca aag cag gag act ggt ggt tta gtc caa gct gtc act      624
 Met Lys Cys Thr Lys Gln Glu Thr Gly Gly Leu Val Gln Ala Val Thr
         195                 200                 205

 caa act ctg tgg gtt aaa agg tct cca ttt att tat ctt ggt gct cat      672
 Gln Thr Leu Trp Val Lys Arg Ser Pro Phe Ile Tyr Leu Gly Ala His
     210                 215                 220

 att aac cag tta aac ggt cga ata gca gtc aac gac tgg gaa aaa cag      720
 Ile Asn Gln Leu Asn Gly Arg Ile Ala Val Asn Asp Trp Glu Lys Gln
 225                 230                 235                 240

 ata ttt gag aag caa aac atc tgt aac act acc agt ctc cga agc aag      768
 Ile Phe Glu Lys Gln Asn Ile Cys Asn Thr Thr Ser Leu Arg Ser Lys
                 245                 250                 255

 aaa tcc gtc atc atc ggc cac tct cgg cct cca acc cta cac gca atc      816
 Lys Ser Val Ile Ile Gly His Ser Arg Pro Pro Thr Leu His Ala Ile
             260                 265                 270

 tgt gac caa gcc ctg tca tct cca ctc aga gcc tct cca ttc acc ctt      864
 Cys Asp Gln Ala Leu Ser Ser Pro Leu Arg Ala Ser Pro Phe Thr Leu
         275                 280                 285

 cct gga cca cag gga aga gtt gtt tta agt ata aac aaa cac aag gga      912
 Pro Gly Pro Gln Gly Arg Val Val Leu Ser Ile Asn Lys His Lys Gly
     290                 295                 300

 atg ccg ttg tca gga cat cct gcc gag ccc cac agc tca gca cca agc      960
 Met Pro Leu Ser Gly His Pro Ala Glu Pro His Ser Ser Ala Pro Ser
 305                 310                 315                 320

 aat cac ttt ctt tcc tgg ggc ctc tct cca aaa acc gat cag agg aga     1008
 Asn His Phe Leu Ser Trp Gly Leu Ser Pro Lys Thr Asp Gln Arg Arg
                 325                 330                 335

 tgt ctg atg aag gat gcc cat acc atc ctt gtg tgc tcc ctg gac att     1056
 Cys Leu Met Lys Asp Ala His Thr Ile Leu Val Cys Ser Leu Asp Ile
             340                 345                 350

 cct gca aat ggc act gtt gtg aca gga aat gac aaa cag atg ccc ctc     1104
 Pro Ala Asn Gly Thr Val Val Thr Gly Asn Asp Lys Gln Met Pro Leu
         355                 360                 365

 gac cct tgc tgc ccc caa gga cat ttg aat ttc aag aca aca tac aat     1152
 Asp Pro Cys Cys Pro Gln Gly His Leu Asn Phe Lys Thr Thr Tyr Asn
     370                 375                 380

 tct tta aat gac aat agc atg caa ttt cag cat cca acc cac atc tgc     1200
 Ser Leu Asn Asp Asn Ser Met Gln Phe Gln His Pro Thr His Ile Cys
 385                 390                 395                 400

 cac aag cct ttt gtc ttc aat caa gtt cgg aag aat ctg ctt gag ttc     1248
 His Lys Pro Phe Val Phe Asn Gln Val Arg Lys Asn Leu Leu Glu Phe
                 405                 410                 415

 aca gtg ctt tct agg agg aat tgg caa atc ata aac aag atc tcc ctc     1296
 Thr Val Leu Ser Arg Arg Asn Trp Gln Ile Ile Asn Lys Ile Ser Leu
             420                 425                 430

 gag aaa ttc tcc gtg gac cct cat tcc cac ccc cac tct ttt gtg ctt     1344
 Glu Lys Phe Ser Val Asp Pro His Ser His Pro His Ser Phe Val Leu
         435                 440                 445

 cag tgc ttt cga acc tgt ctg cta gaa tgt ggg aga atc atc tgc ctg     1392
 Gln Cys Phe Arg Thr Cys Leu Leu Glu Cys Gly Arg Ile Ile Cys Leu
     450                 455                 460

 caa gtg aag gca gca ttt ttc aca gaa aca tgc acg aag gtg cta aac     1440
 Gln Val Lys Ala Ala Phe Phe Thr Glu Thr Cys Thr Lys Val Leu Asn
 465                 470                 475                 480

 aag ctt gtc tgc tgc tca aag ggg gac ctt cta agg cag cag ctt ccc     1488
 Lys Leu Val Cys Cys Ser Lys Gly Asp Leu Leu Arg Gln Gln Leu Pro
                 485                 490                 495

 aag gac att cta agg acc tca gcc aag tct ctg ctg tgg cag gac cag     1536
 Lys Asp Ile Leu Arg Thr Ser Ala Lys Ser Leu Leu Trp Gln Asp Gln
             500                 505                 510

 gat ttg gca aat ccc agc gac cca acc cag gaa aag ccc cac agg aga     1584
 Asp Leu Ala Asn Pro Ser Asp Pro Thr Gln Glu Lys Pro His Arg Arg
         515                 520                 525

 ccc aga agg agc aag gca atg gac caa gct gag aaa ctg agg cta gga     1632
 Pro Arg Arg Ser Lys Ala Met Asp Gln Ala Glu Lys Leu Arg Leu Gly
     530                 535                 540

 gaa aag agg aga gcc cac agg ctg cag ctg gca gag cct act gca gat     1680
 Glu Lys Arg Arg Ala His Arg Leu Gln Leu Ala Glu Pro Thr Ala Asp
 545                 550                 555                 560

 ctc att ttt ctg cct ggc aat tca tct ata gac ctg agc agg gaa ccc     1728
 Leu Ile Phe Leu Pro Gly Asn Ser Ser Ile Asp Leu Ser Arg Glu Pro
                 565                 570                 575

 att ttt gca caa gct gga cca gtc ccc gtg gcc ttg ggg aca cag tac     1776
 Ile Phe Ala Gln Ala Gly Pro Val Pro Val Ala Leu Gly Thr Gln Tyr
             580                 585                 590

 cac cca gga aga ttc ttc ctt gtt cag acg gtc att att cct ttc atg     1824
 His Pro Gly Arg Phe Phe Leu Val Gln Thr Val Ile Ile Pro Phe Met
         595                 600                 605

 tat gtc cgc aac cct aaa gca gtg ttg caa gtt ctg gcc agg gca att     1872
 Tyr Val Arg Asn Pro Lys Ala Val Leu Gln Val Leu Ala Arg Ala Ile
     610                 615                 620

 agg cag gag aag gaa ata aag ggt att caa tta gga aaa gag gaa gtc     1920
 Arg Gln Glu Lys Glu Ile Lys Gly Ile Gln Leu Gly Lys Glu Glu Val
 625                 630                 635                 640

 aaa ttg tcc ctg ttt gca gat gac atg att gta tat cta gaa aac ccc     1968
 Lys Leu Ser Leu Phe Ala Asp Asp Met Ile Val Tyr Leu Glu Asn Pro
                 645                 650                 655

 acc gtc tca gcc caa aat ctc ctt aag ctg ata ggc aac ttc agc aaa     2016
 Thr Val Ser Ala Gln Asn Leu Leu Lys Leu Ile Gly Asn Phe Ser Lys
             660                 665                 670

 gtc tca gga tac aaa atc aat gtg caa aaa tca caa gca ttc tta tac     2064
 Val Ser Gly Tyr Lys Ile Asn Val Gln Lys Ser Gln Ala Phe Leu Tyr
         675                 680                 685

 acc aat aac aga caa aca gag agc caa atc atg agt gaa ctc cca ttc     2112
 Thr Asn Asn Arg Gln Thr Glu Ser Gln Ile Met Ser Glu Leu Pro Phe
     690                 695                 700

 aca att gct tca aag aga ata aaa tac cta gga atc caa ctt aca aag     2160
 Thr Ile Ala Ser Lys Arg Ile Lys Tyr Leu Gly Ile Gln Leu Thr Lys
 705                 710                 715                 720

 gat gtg aag gac ctc ttc aag gag aac tac aaa aca ctg ctc aat gaa     2208
 Asp Val Lys Asp Leu Phe Lys Glu Asn Tyr Lys Thr Leu Leu Asn Glu
                 725                 730                 735

 ata aaa gag gac aca aac aaa tgg aag aac att cca tgc tca tgg ata     2256
 Ile Lys Glu Asp Thr Asn Lys Trp Lys Asn Ile Pro Cys Ser Trp Ile
             740                 745                 750

 gga aga atc aat atc gtg aaa atg gcc ata ctg ccc aag gat aaa ccc     2304
 Gly Arg Ile Asn Ile Val Lys Met Ala Ile Leu Pro Lys Asp Lys Pro
         755                 760                 765

 cca cac aca ctc aaa gtg cct gtg aag acc cca ctg agc tcc act cac     2352
 Pro His Thr Leu Lys Val Pro Val Lys Thr Pro Leu Ser Ser Thr His
     770                 775                 780

 atc tac tgg ggc ctc tat ggg gtg ggg gtt tgc cag ctt gtt agt gga     2400
 Ile Tyr Trp Gly Leu Tyr Gly Val Gly Val Cys Gln Leu Val Ser Gly
 785                 790                 795                 800

 gag gaa ata gta gtt ata tcc cat ctg tcc tcc atg act ctc aca agc     2448
 Glu Glu Ile Val Val Ile Ser His Leu Ser Ser Met Thr Leu Thr Ser
                 805                 810                 815

 aaa tca gaa agt ggt ggg gac atg ccg ata gat gag gag gtt cca gaa     2496
 Lys Ser Glu Ser Gly Gly Asp Met Pro Ile Asp Glu Glu Val Pro Glu
             820                 825                 830

 cca aga tac acc cac cct ggg aaa gaa aca ttc tgt aag cta aag aaa     2544
 Pro Arg Tyr Thr His Pro Gly Lys Glu Thr Phe Cys Lys Leu Lys Lys
         835                 840                 845

 aag aac att gaa aat tta gta aac agg aca att gat ggc acc tgg ctt     2592
 Lys Asn Ile Glu Asn Leu Val Asn Arg Thr Ile Asp Gly Thr Trp Leu
     850                 855                 860

 tgt gtc aag caa aag ccg gtc tct gca gtg aaa agt cct gac ctt gaa     2640
 Cys Val Lys Gln Lys Pro Val Ser Ala Val Lys Ser Pro Asp Leu Glu
 865                 870                 875                 880

 aag ctg gtt aaa atg gat gat gcg tgg gct gct ggc tgg aga gcc agc     2688
 Lys Leu Val Lys Met Asp Asp Ala Trp Ala Ala Gly Trp Arg Ala Ser
                 885                 890                 895

 ggg aag tag                                                         2697
 Gly Lys 






      <210> 645
      <211> 1566
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (1)..(1566)

      <400> 645
  atg atc ttt gaa atg gct gca ggt gaa ggc ttg caa gaa aac gcg gta      48
  Met Ile Phe Glu Met Ala Ala Gly Glu Gly Leu Gln Glu Asn Ala Val
    1               5                  10                  15

 aca ttg ccc cgt gct gtt gct cac gtt tta gct ctc att gca ttt cta       96
 Thr Leu Pro Arg Ala Val Ala His Val Leu Ala Leu Ile Ala Phe Leu
              20                  25                  30

 ttg gac agt gct gct cta gac ctt gca gat ttt tca gaa tca tct gat      144
 Leu Asp Ser Ala Ala Leu Asp Leu Ala Asp Phe Ser Glu Ser Ser Asp
          35                  40                  45

 tct gaa tca caa tat gga gca tca ggg gcc ctt tcc tgg act tgt ctg      192
 Ser Glu Ser Gln Tyr Gly Ala Ser Gly Ala Leu Ser Trp Thr Cys Leu
      50                  55                  60

 tct cag gct gac ttg aca gga att aag tgg aaa aaa tat gta tgg caa      240
 Ser Gln Ala Asp Leu Thr Gly Ile Lys Trp Lys Lys Tyr Val Trp Gln
  65                  70                  75                  80

 ggc cca act tct gcc cct att ctg ttt cct gtg aca gaa gaa gac ccc      288
 Gly Pro Thr Ser Ala Pro Ile Leu Phe Pro Val Thr Glu Glu Asp Pro
                  85                  90                  95

 att ttg agc agt ttt agt cgc tgc ctt aag gca gat gta ctt ggt gtt      336
 Ile Leu Ser Ser Phe Ser Arg Cys Leu Lys Ala Asp Val Leu Gly Val
             100                 105                 110

 tgg cgg cga gat caa aga cct gga aga aga gaa ttg tgg ata ttt tgg      384
 Trp Arg Arg Asp Gln Arg Pro Gly Arg Arg Glu Leu Trp Ile Phe Trp
         115                 120                 125

 tgg ggt gaa gac ccc agt ttt gct gac ctt att cac cat gac tta tca      432
 Trp Gly Glu Asp Pro Ser Phe Ala Asp Leu Ile His His Asp Leu Ser
     130                 135                 140

 gaa gaa gaa gat gga gtg tgg gag aat gga ctt tcc tat gaa tgc cgt      480
 Glu Glu Glu Asp Gly Val Trp Glu Asn Gly Leu Ser Tyr Glu Cys Arg
 145                 150                 155                 160

 act ctg ctt ttc aaa gca gtt cac aat cta ttg gaa cgg tgt tta atg      528
 Thr Leu Leu Phe Lys Ala Val His Asn Leu Leu Glu Arg Cys Leu Met
                 165                 170                 175

 aac agg aat ttt gta cgt att ggc aag tgg ttt gta aag cct tat gaa      576
 Asn Arg Asn Phe Val Arg Ile Gly Lys Trp Phe Val Lys Pro Tyr Glu
             180                 185                 190

 aaa gat gaa aaa cct ata aat aaa agg aac ttt ctt acc ctt ttt cct      624
 Lys Asp Glu Lys Pro Ile Asn Lys Arg Asn Phe Leu Thr Leu Phe Pro
         195                 200                 205

 tct ttg gaa aag caa gaa ata gta aaa acc ata ata ctt aaa aac aac      672
 Ser Leu Glu Lys Gln Glu Ile Val Lys Thr Ile Ile Leu Lys Asn Asn
     210                 215                 220

 aat aaa aag cag cat ttt gca gaa cac ttg aag tgt gaa cac ttg tcc      720
 Asn Lys Lys Gln His Phe Ala Glu His Leu Lys Cys Glu His Leu Ser
 225                 230                 235                 240

 tgc tcc ttc acc ttt ttc ttg cat gga gac agc aat gtt tgt acc agt      768
 Cys Ser Phe Thr Phe Phe Leu His Gly Asp Ser Asn Val Cys Thr Ser
                 245                 250                 255

 gtg gaa att aac caa cat caa cct gta tac ctt ctc agt gaa gag cat      816
 Val Glu Ile Asn Gln His Gln Pro Val Tyr Leu Leu Ser Glu Glu His
             260                 265                 270

 atc acc ctt gct caa cag tct aat agc cca ttt caa gga cag gca ttc      864
 Ile Thr Leu Ala Gln Gln Ser Asn Ser Pro Phe Gln Gly Gln Ala Phe
         275                 280                 285

 aag atg tct gat tca gct aca aaa aaa tta att ggt gaa tgg aaa cag      912
 Lys Met Ser Asp Ser Ala Thr Lys Lys Leu Ile Gly Glu Trp Lys Gln
     290                 295                 300

 ttc tat cct atc tca tgt tgc ttg aag gag atg tct gaa gaa aaa cag      960
 Phe Tyr Pro Ile Ser Cys Cys Leu Lys Glu Met Ser Glu Glu Lys Gln
 305                 310                 315                 320

 gaa gat atg gat tgg gaa gat gat tct tta gct gca gta gaa gtt ctt     1008
 Glu Asp Met Asp Trp Glu Asp Asp Ser Leu Ala Ala Val Glu Val Leu
                 325                 330                 335

 gtt gct ggt gtc cga atg atc tac cca gca tgc ttt gtt cta gtc cct     1056
 Val Ala Gly Val Arg Met Ile Tyr Pro Ala Cys Phe Val Leu Val Pro
             340                 345                 350

 cag tca gac att cct act cct agc cct gtg gga tcc act cac tgt tca     1104
 Gln Ser Asp Ile Pro Thr Pro Ser Pro Val Gly Ser Thr His Cys Ser
         355                 360                 365

 tct tct tgc ttg ggt gtc cac caa gtg cct gct tcc aca aga gat cct     1152
 Ser Ser Cys Leu Gly Val His Gln Val Pro Ala Ser Thr Arg Asp Pro
     370                 375                 380

 gct atg tct tcg gtt acg ctt aca cca cct acg tct cct gag gaa gtc     1200
 Ala Met Ser Ser Val Thr Leu Thr Pro Pro Thr Ser Pro Glu Glu Val
 385                 390                 395                 400

 caa aca ggt ata gca gta att tgt ctc atc agc tct gtt gat cct cag     1248
 Gln Thr Gly Ile Ala Val Ile Cys Leu Ile Ser Ser Val Asp Pro Gln
                 405                 410                 415

 tct gtc cag aag tgg gtc aaa ttt tct tca gta tct gat ggc ttc aac     1296
 Ser Val Gln Lys Trp Val Lys Phe Ser Ser Val Ser Asp Gly Phe Asn
             420                 425                 430

 tcc gat agt act agc cac cat ggt ggg aaa ata ccc aga aaa tta gca     1344
 Ser Asp Ser Thr Ser His His Gly Gly Lys Ile Pro Arg Lys Leu Ala
         435                 440                 445

 aat cat gtg gtg gat aga gtt tgg caa gaa tgc aat atg aac aga gca     1392
 Asn His Val Val Asp Arg Val Trp Gln Glu Cys Asn Met Asn Arg Ala
     450                 455                 460

 cag aac aag att gcc ttg gct att tgg gct ctt ttt gaa ttt cat aga     1440
 Gln Asn Lys Ile Ala Leu Ala Ile Trp Ala Leu Phe Glu Phe His Arg
 465                 470                 475                 480

 aat tta aaa ata gtt ttt cct agt tct gtg aag aat gtc att ggt agt     1488
 Asn Leu Lys Ile Val Phe Pro Ser Ser Val Lys Asn Val Ile Gly Ser
                 485                 490                 495

 ttg ata aga ata gca ttg aat cca aat tgc ttt ggg cag tat ggc cat     1536
 Leu Ile Arg Ile Ala Leu Asn Pro Asn Cys Phe Gly Gln Tyr Gly His
             500                 505                 510

 ttt aag gat att gat tct tcc tat cca tga                             1566
 Phe Lys Asp Ile Asp Ser Ser Tyr Pro 
         515                 520





      <210> 646
      <211> 3529
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (143)..(3529)

      <400> 646
 ctctagtgat ggcagctggt ggacagggtt tcagtggaga gaatggaggc aggcagggag     60

 atcggtgaac tcttgggaca atcccaaaca ggaagttaga gcttcaagta aggacaagag    120

 caggggaagc attcaagagg cg atg agg atg caa agt tca gcg aag ctg ctg     172
                          Met Arg Met Gln Ser Ser Ala Lys Leu Leu
                            1               5                  10

 tgt tct gcc tgg act cta gct tac tcc att gca gta agg aca ttg tcc      220
 Cys Ser Ala Trp Thr Leu Ala Tyr Ser Ile Ala Val Arg Thr Leu Ser
                  15                  20                  25

 tca gac agc gag ggc cag cct ccg ctg gtg ata cac agg caa aca ggg      268
 Ser Asp Ser Glu Gly Gln Pro Pro Leu Val Ile His Arg Gln Thr Gly
              30                  35                  40

 tct gga gag gac ctc cag caa act cca aca gac ctg cag ctg agg gtc      316
 Ser Gly Glu Asp Leu Gln Gln Thr Pro Thr Asp Leu Gln Leu Arg Val
          45                  50                  55

 ctg act att aga agg aaa act aac aaa cag aaa gga cat cca cac caa      364
 Leu Thr Ile Arg Arg Lys Thr Asn Lys Gln Lys Gly His Pro His Gln
      60                  65                  70

 aac ccc atc tct agc aga aga caa gaa ata act aag atc aga gca gaa      412
 Asn Pro Ile Ser Ser Arg Arg Gln Glu Ile Thr Lys Ile Arg Ala Glu
  75                  80                  85                  90

 ctg aag aag ata gag aca caa aaa ccc ttc aaa aaa atc aat gaa tcc      460
 Leu Lys Lys Ile Glu Thr Gln Lys Pro Phe Lys Lys Ile Asn Glu Ser
                  95                 100                 105

 agg agc tgg ttt ttt gaa aag atc aac aaa att gat aga ctg cta gca      508
 Arg Ser Trp Phe Phe Glu Lys Ile Asn Lys Ile Asp Arg Leu Leu Ala
             110                 115                 120

 aga cta ata aag aag aaa ata gag aag aat caa ata gat gca ata aaa      556
 Arg Leu Ile Lys Lys Lys Ile Glu Lys Asn Gln Ile Asp Ala Ile Lys
         125                 130                 135

 aat gat aaa ggg aat atc acc acc aat ccc aca gaa ata caa act acc      604
 Asn Asp Lys Gly Asn Ile Thr Thr Asn Pro Thr Glu Ile Gln Thr Thr
     140                 145                 150

 atc aga gaa tac tat aaa cac ctc tat gca aat aaa cta gaa cac cta      652
 Ile Arg Glu Tyr Tyr Lys His Leu Tyr Ala Asn Lys Leu Glu His Leu
 155                 160                 165                 170

 gaa gaa atg gat aaa ttc ctg gac ata tac acc ctc cca aga cta aac      700
 Glu Glu Met Asp Lys Phe Leu Asp Ile Tyr Thr Leu Pro Arg Leu Asn
                 175                 180                 185

 cag gaa gaa gtt gaa tct gtg aat aga cca ata aca ggt tct gaa att      748
 Gln Glu Glu Val Glu Ser Val Asn Arg Pro Ile Thr Gly Ser Glu Ile
             190                 195                 200

 gag gca ata att aat agt cta cca acc aaa aaa agt cca gga cca gac      796
 Glu Ala Ile Ile Asn Ser Leu Pro Thr Lys Lys Ser Pro Gly Pro Asp
         205                 210                 215

 aga ttc aca gct gaa ctc tac cag agg tac aaa gag gag ctg gta cca      844
 Arg Phe Thr Ala Glu Leu Tyr Gln Arg Tyr Lys Glu Glu Leu Val Pro
     220                 225                 230

 ttc ctt ctg aaa cta ttc caa tca ata gaa aaa gag gga atc ctc cct      892
 Phe Leu Leu Lys Leu Phe Gln Ser Ile Glu Lys Glu Gly Ile Leu Pro
 235                 240                 245                 250

 aat tca ttt tat gag gcc agc atc atc ctg ata tca aag cct ggc aga      940
 Asn Ser Phe Tyr Glu Ala Ser Ile Ile Leu Ile Ser Lys Pro Gly Arg
                 255                 260                 265

 gac aca aca aaa aaa gag aat ttt aga cca ata tcc ctg atg aac atc      988
 Asp Thr Thr Lys Lys Glu Asn Phe Arg Pro Ile Ser Leu Met Asn Ile
             270                 275                 280

 gat gca aaa atc ctc aat aaa ata ctg gca aac caa atc cag cag cac     1036
 Asp Ala Lys Ile Leu Asn Lys Ile Leu Ala Asn Gln Ile Gln Gln His
         285                 290                 295

 atc aaa aag ctt atc cac cac cat caa gtt ggc ttc atc cct ggg atg     1084
 Ile Lys Lys Leu Ile His His His Gln Val Gly Phe Ile Pro Gly Met
     300                 305                 310

 caa ggc tgg ttc aac ata ctc aaa tca ata aac gta atc cat cat ata     1132
 Gln Gly Trp Phe Asn Ile Leu Lys Ser Ile Asn Val Ile His His Ile
 315                 320                 325                 330

 aac aga acc aaa gac aaa aac cac atg att atc tca ata gaa gca gaa     1180
 Asn Arg Thr Lys Asp Lys Asn His Met Ile Ile Ser Ile Glu Ala Glu
                 335                 340                 345

 aag gcc ttt gac aaa att caa cag ccc ttt atg cta aaa act ctc aat     1228
 Lys Ala Phe Asp Lys Ile Gln Gln Pro Phe Met Leu Lys Thr Leu Asn
             350                 355                 360

 aaa cta ggt att gat ggg aca tat ctg aca tat ctc aaa ata ata aga     1276
 Lys Leu Gly Ile Asp Gly Thr Tyr Leu Thr Tyr Leu Lys Ile Ile Arg
         365                 370                 375

 gct att tat gac aaa ccc aca gcc aat atc ata ctg aat ggg caa aaa     1324
 Ala Ile Tyr Asp Lys Pro Thr Ala Asn Ile Ile Leu Asn Gly Gln Lys
     380                 385                 390

 ctg gaa gca ttc cct ttt aag act ggc aca aga cag gga tgt cct ctc     1372
 Leu Glu Ala Phe Pro Phe Lys Thr Gly Thr Arg Gln Gly Cys Pro Leu
 395                 400                 405                 410

 tca cca ctc cta ttc aac ata gtg ttg gaa gct ctg gcc agg gca atc     1420
 Ser Pro Leu Leu Phe Asn Ile Val Leu Glu Ala Leu Ala Arg Ala Ile
                 415                 420                 425

 agg caa gag aaa gaa ata aag ggt att caa tta gga aaa gag gat gtc     1468
 Arg Gln Glu Lys Glu Ile Lys Gly Ile Gln Leu Gly Lys Glu Asp Val
             430                 435                 440

 aaa ttg tcc ctg ttt gca gat gac atg att gta tat tta gaa aac ccc     1516
 Lys Leu Ser Leu Phe Ala Asp Asp Met Ile Val Tyr Leu Glu Asn Pro
         445                 450                 455

 atc gtc tca gcc caa aat ctc ctt aag ctg ata agc aac ttc agc gaa     1564
 Ile Val Ser Ala Gln Asn Leu Leu Lys Leu Ile Ser Asn Phe Ser Glu
     460                 465                 470

 gtc tca gga tac aaa atc aat gtg caa aaa tca caa gca ttc cta tac     1612
 Val Ser Gly Tyr Lys Ile Asn Val Gln Lys Ser Gln Ala Phe Leu Tyr
 475                 480                 485                 490

 acc aat aac aga cag aca gag agc caa atc atg agt gaa ctc cca ttc     1660
 Thr Asn Asn Arg Gln Thr Glu Ser Gln Ile Met Ser Glu Leu Pro Phe
                 495                 500                 505

 aca att gct tca aag aga ata aaa tac cta gga ata caa ctt aca agg     1708
 Thr Ile Ala Ser Lys Arg Ile Lys Tyr Leu Gly Ile Gln Leu Thr Arg
             510                 515                 520

 gat gtg aag gac ctc ttc aag gag aac tac aaa cca ctg ctc aat gaa     1756
 Asp Val Lys Asp Leu Phe Lys Glu Asn Tyr Lys Pro Leu Leu Asn Glu
         525                 530                 535

 ata aaa gag gac aca aac aaa tgg aag aac att cca tgc tca tgg ata     1804
 Ile Lys Glu Asp Thr Asn Lys Trp Lys Asn Ile Pro Cys Ser Trp Ile
     540                 545                 550

 gga aga atc aat att gtg aaa atg gcc ata ctg ccc aag act ctc aat     1852
 Gly Arg Ile Asn Ile Val Lys Met Ala Ile Leu Pro Lys Thr Leu Asn
 555                 560                 565                 570

 cag aaa ttc tca tac tgg ttc aga gtc aac aaa cac tac att cac cag     1900
 Gln Lys Phe Ser Tyr Trp Phe Arg Val Asn Lys His Tyr Ile His Gln
                 575                 580                 585

 agg act ttt ccc ctc aaa gag aca gaa ttc aac acc ata gca acg ctt     1948
 Arg Thr Phe Pro Leu Lys Glu Thr Glu Phe Asn Thr Ile Ala Thr Leu
             590                 595                 600

 tat aat ggt gct tct cca gca cag cac caa aaa gca ctg gaa cca atg     1996
 Tyr Asn Gly Ala Ser Pro Ala Gln His Gln Lys Ala Leu Glu Pro Met
         605                 610                 615

 gcc atc aag cat cag gat tgc cac ggt tct gaa gaa ttg cct ttt gca     2044
 Ala Ile Lys His Gln Asp Cys His Gly Ser Glu Glu Leu Pro Phe Ala
     620                 625                 630

 gtg ctc ttg tca agt cta aac gaa aac tct atc agg gtt att tgc ctg     2092
 Val Leu Leu Ser Ser Leu Asn Glu Asn Ser Ile Arg Val Ile Cys Leu
 635                 640                 645                 650

 gtc aga cag ata gga ggg aag agg gag ttt ctt ggt gtc cag gtg gtc     2140
 Val Arg Gln Ile Gly Gly Lys Arg Glu Phe Leu Gly Val Gln Val Val
                 655                 660                 665

 ctt aag aca aag cca gaa ctg gca ttt cca gtg gag gga gga cta caa     2188
 Leu Lys Thr Lys Pro Glu Leu Ala Phe Pro Val Glu Gly Gly Leu Gln
             670                 675                 680

 ggt caa agg tgg ata agc aat tac ctc tat gaa gga aac ggg cag gga     2236
 Gly Gln Arg Trp Ile Ser Asn Tyr Leu Tyr Glu Gly Asn Gly Gln Gly
         685                 690                 695

 gat gaa aag gag aaa agc aac acg gag gat agg aaa agc ctt tcc atg     2284
 Asp Glu Lys Glu Lys Ser Asn Thr Glu Asp Arg Lys Ser Leu Ser Met
     700                 705                 710

 gag atg atg ttc cag cca aga cag gaa ggg gta gaa cga gcc agc gag     2332
 Glu Met Met Phe Gln Pro Arg Gln Glu Gly Val Glu Arg Ala Ser Glu
 715                 720                 725                 730

 gcc aag ggc agg atg ggg gtg ggc aag gat act gag aaa cag ctc ctg     2380
 Ala Lys Gly Arg Met Gly Val Gly Lys Asp Thr Glu Lys Gln Leu Leu
                 735                 740                 745

 gag gag gag tcg gcc agg gca cag gcc tgg agg cgg aaa tgt gct ggg     2428
 Glu Glu Glu Ser Ala Arg Ala Gln Ala Trp Arg Arg Lys Cys Ala Gly
             750                 755                 760

 tgc atg gtc aca gaa tcc agg atg tta ttt tgg ctt tct gga gac aag     2476
 Cys Met Val Thr Glu Ser Arg Met Leu Phe Trp Leu Ser Gly Asp Lys
         765                 770                 775

 ggc cca cag ttc gtc acc atg ggt cca gca gaa ggc cca gct aga tct     2524
 Gly Pro Gln Phe Val Thr Met Gly Pro Ala Glu Gly Pro Ala Arg Ser
     780                 785                 790

 aag aat caa cac aaa aag att gaa agc ttt aaa cac ctg agt ttg gat     2572
 Lys Asn Gln His Lys Lys Ile Glu Ser Phe Lys His Leu Ser Leu Asp
 795                 800                 805                 810

 aat tct agc cag gaa gag acc cca gga cca ggc cag tgt cat tac cac     2620
 Asn Ser Ser Gln Glu Glu Thr Pro Gly Pro Gly Gln Cys His Tyr His
                 815                 820                 825

 ctc cag caa ctc ccc tca gct ccc cac aag gag gcg aaa gca acc caa     2668
 Leu Gln Gln Leu Pro Ser Ala Pro His Lys Glu Ala Lys Ala Thr Gln
             830                 835                 840

 cac aaa cgt gtg tgc cca agc atc tcc tct cag tcc ttg acc cct tca     2716
 His Lys Arg Val Cys Pro Ser Ile Ser Ser Gln Ser Leu Thr Pro Ser
         845                 850                 855

 tct tta ctc tct aaa gat att act aca gca cct tgc aaa ttg aat tta     2764
 Ser Leu Leu Ser Lys Asp Ile Thr Thr Ala Pro Cys Lys Leu Asn Leu
     860                 865                 870

 aca aag gac cta tgt ttg atg aat gaa cag cca tac aga aat gtg att     2812
 Thr Lys Asp Leu Cys Leu Met Asn Glu Gln Pro Tyr Arg Asn Val Ile
 875                 880                 885                 890

 gga cac aaa gga tct ggc cta acg gtg aag gac gga gtg ggg aaa ccc     2860
 Gly His Lys Gly Ser Gly Leu Thr Val Lys Asp Gly Val Gly Lys Pro
                 895                 900                 905

 agc aaa acc aca gaa ttt ttt act gag tac ttc agt tac aag aaa agc     2908
 Ser Lys Thr Thr Glu Phe Phe Thr Glu Tyr Phe Ser Tyr Lys Lys Ser
             910                 915                 920

 tat cca aaa aaa ccc tac aaa tgc atc caa aga cag ctt ctg ctc atc     2956
 Tyr Pro Lys Lys Pro Tyr Lys Cys Ile Gln Arg Gln Leu Leu Leu Ile
         925                 930                 935

 cag agc caa gaa gaa cta gca ggc aat cat gtg cag agg cct tta gct     3004
 Gln Ser Gln Glu Glu Leu Ala Gly Asn His Val Gln Arg Pro Leu Ala
     940                 945                 950

 tta gag ttt ggg gcg ctt ttt tct cct gga ggt gcc agc tgg ggt ttt     3052
 Leu Glu Phe Gly Ala Leu Phe Ser Pro Gly Gly Ala Ser Trp Gly Phe
 955                 960                 965                 970

 ggg gac ttg aaa agt tac ctg ggg cta cag aac aca gtg tcc acg cac     3100
 Gly Asp Leu Lys Ser Tyr Leu Gly Leu Gln Asn Thr Val Ser Thr His
                 975                 980                 985

 ttg gac aag ctg cct ctt ctg ggt gaa agg cac atg tcc cac cag aca     3148
 Leu Asp Lys Leu Pro Leu Leu Gly Glu Arg His Met Ser His Gln Thr
             990                 995                1000

 ccc atg agc cat cct tgg ccc ctc tct gga acc tta ccc ctc aca tcc     3196
 Pro Met Ser His Pro Trp Pro Leu Ser Gly Thr Leu Pro Leu Thr Ser
        1005                1010                1015

 cat aaa tcc cca agg act gtg cat cca cct gct gaa cat cac caa agt     3244
 His Lys Ser Pro Arg Thr Val His Pro Pro Ala Glu His His Gln Ser
    1020                1025                1030

 cca ctt cca att cca ctc cca gtg act gca aag ggg gcc ttt gcc tcg     3292
 Pro Leu Pro Ile Pro Leu Pro Val Thr Ala Lys Gly Ala Phe Ala Ser
1035                1040                1045                1050

 gtg cca cca tta cta ttc cct gct cca caa gga tta tcg aat gag ggc     3340
 Val Pro Pro Leu Leu Phe Pro Ala Pro Gln Gly Leu Ser Asn Glu Gly
                1055                1060                1065

 aga aga tgt cat ggg tat att ttg ata aat att tca ggc att aca aac     3388
 Arg Arg Cys His Gly Tyr Ile Leu Ile Asn Ile Ser Gly Ile Thr Asn
            1070                1075                1080

 aat act gaa ata tat gcc agt ctt gta acc atc aca ctg caa cat ttt     3436
 Asn Thr Glu Ile Tyr Ala Ser Leu Val Thr Ile Thr Leu Gln His Phe
        1085                1090                1095

 ctg ctg cct tct gaa gac tgt gga aaa gcc ccc ttg caa ggg agg gtg     3484
 Leu Leu Pro Ser Glu Asp Cys Gly Lys Ala Pro Leu Gln Gly Arg Val
    1100                1105                1110

 gaa gga aga gag gga gtt tct cag aaa gag aag aga aaa acc taa         3529
 Glu Gly Arg Glu Gly Val Ser Gln Lys Glu Lys Arg Lys Thr 
1115                1120                1125





      <210> 647
      <211> 5211
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (1)..(5211)

      <400> 647
  atg tgg gct ctc tgg aag gtc acc aag cat ctc ctt gct ttg tcg ccc      48
  Met Trp Ala Leu Trp Lys Val Thr Lys His Leu Leu Ala Leu Ser Pro
    1               5                  10                  15

 acc ctg tgg gct ggg gca tac cgg gaa gtc cac act gca acc tct gcc       96
 Thr Leu Trp Ala Gly Ala Tyr Arg Glu Val His Thr Ala Thr Ser Ala
              20                  25                  30

 ctc cag caa ata ggc agg act gac gca cca ggc cac agg gag cct tgg      144
 Leu Gln Gln Ile Gly Arg Thr Asp Ala Pro Gly His Arg Glu Pro Trp
          35                  40                  45

 agg agg gga gaa tgt gtg cgc caa tgc ggg ctg cat tgt aaa gaa gag      192
 Arg Arg Gly Glu Cys Val Arg Gln Cys Gly Leu His Cys Lys Glu Glu
      50                  55                  60

 gaa gag ttc tgc gag tta ctc tac aga tat tct caa atg caa acc aaa      240
 Glu Glu Phe Cys Glu Leu Leu Tyr Arg Tyr Ser Gln Met Gln Thr Lys
  65                  70                  75                  80

 tca ggt tct cag gtt cag atg cac ctt cta ggc ttt aat atg ggc ata      288
 Ser Gly Ser Gln Val Gln Met His Leu Leu Gly Phe Asn Met Gly Ile
                  85                  90                  95

 gga aac cag ctt cct ggt ggg gtc aag aac aag gca aga agg ccc gag      336
 Gly Asn Gln Leu Pro Gly Gly Val Lys Asn Lys Ala Arg Arg Pro Glu
             100                 105                 110

 gtg tcc caa gat aag atg ggc ttt ctc ttt agg tta agt agc ctg tct      384
 Val Ser Gln Asp Lys Met Gly Phe Leu Phe Arg Leu Ser Ser Leu Ser
         115                 120                 125

 tct ctg gga gat tct gca cca gag cgc aag tcc cct tcc cac cat cgc      432
 Ser Leu Gly Asp Ser Ala Pro Glu Arg Lys Ser Pro Ser His His Arg
     130                 135                 140

 cag cct tcg gat gcc tct gag aca aca ggt ctc gtt caa cgc tgt gtc      480
 Gln Pro Ser Asp Ala Ser Glu Thr Thr Gly Leu Val Gln Arg Cys Val
 145                 150                 155                 160

 att atc caa aag gac cag cat ggc ttc ggc ttc aca gtc agt ggg gat      528
 Ile Ile Gln Lys Asp Gln His Gly Phe Gly Phe Thr Val Ser Gly Asp
                 165                 170                 175

 cgc att gtt ctg gtg cag tct gtg cgg cct gga ggt gca gcc atg aag      576
 Arg Ile Val Leu Val Gln Ser Val Arg Pro Gly Gly Ala Ala Met Lys
             180                 185                 190

 gcc ggt gtg aaa gag ggc gac cgg atc atc aaa gtc aac ggc acc atg      624
 Ala Gly Val Lys Glu Gly Asp Arg Ile Ile Lys Val Asn Gly Thr Met
         195                 200                 205

 gtg acc aat agc tca cac ctg gaa gtg gta aag ctg atc aaa tct ggc      672
 Val Thr Asn Ser Ser His Leu Glu Val Val Lys Leu Ile Lys Ser Gly
     210                 215                 220

 gcc tat gtc gca ctc acc ctc ctg ggc tct tca cct tca tcc atg ggc      720
 Ala Tyr Val Ala Leu Thr Leu Leu Gly Ser Ser Pro Ser Ser Met Gly
 225                 230                 235                 240

 atc tct ggg ctc cag cag gac cca tcc cca gca gga gct ccc cga atc      768
 Ile Ser Gly Leu Gln Gln Asp Pro Ser Pro Ala Gly Ala Pro Arg Ile
                 245                 250                 255

 acg tca gtg atc ccc tca cca cca cct cct cca cct cta cca cct cca      816
 Thr Ser Val Ile Pro Ser Pro Pro Pro Pro Pro Pro Leu Pro Pro Pro
             260                 265                 270

 caa cgc atc aca gga ccc aaa cct ctg cag gat ccc gaa gtt caa aaa      864
 Gln Arg Ile Thr Gly Pro Lys Pro Leu Gln Asp Pro Glu Val Gln Lys
         275                 280                 285

 cat gcc acc cag atc ctc agg aat atg ctg agg cag gaa gaa aaa gaa      912
 His Ala Thr Gln Ile Leu Arg Asn Met Leu Arg Gln Glu Glu Lys Glu
     290                 295                 300

 tta cag cgt atc tgt gag gtc tat agc cgg aac ccc gcc agc cta ctg      960
 Leu Gln Arg Ile Cys Glu Val Tyr Ser Arg Asn Pro Ala Ser Leu Leu
 305                 310                 315                 320

 gaa gag cag atc gaa ggt gcc cgg cgg cga gtc act cag tta cag ctg     1008
 Glu Glu Gln Ile Glu Gly Ala Arg Arg Arg Val Thr Gln Leu Gln Leu
                 325                 330                 335

 aag atc cag cag gag act ggt ggc tca gtg gac ata ctt cca cta tat     1056
 Lys Ile Gln Gln Glu Thr Gly Gly Ser Val Asp Ile Leu Pro Leu Tyr
             340                 345                 350

 ggt gac acc agc cag aga cca tca gaa ggc cgg ctc tct ctg gat tcc     1104
 Gly Asp Thr Ser Gln Arg Pro Ser Glu Gly Arg Leu Ser Leu Asp Ser
         355                 360                 365

 cag gag ggg gac agt ggc ttg gac tct ggg aca gaa cgc ttt cct tcc     1152
 Gln Glu Gly Asp Ser Gly Leu Asp Ser Gly Thr Glu Arg Phe Pro Ser
     370                 375                 380

 ctc agt gag tca ttg atg aat cgg aac tcg gta ctg tca gac cct ggg     1200
 Leu Ser Glu Ser Leu Met Asn Arg Asn Ser Val Leu Ser Asp Pro Gly
 385                 390                 395                 400

 cta gac agt cct cga acc tcc cct gtg atc atg gcc agg gtg gcc cag     1248
 Leu Asp Ser Pro Arg Thr Ser Pro Val Ile Met Ala Arg Val Ala Gln
                 405                 410                 415

 cac cac agg cgg cag ggc tcg gat gca gca gtc ccc tca acc ggt gac     1296
 His His Arg Arg Gln Gly Ser Asp Ala Ala Val Pro Ser Thr Gly Asp
             420                 425                 430

 cag ggt gta gat caa agc cca aag cct tta att att ggc cca gag gaa     1344
 Gln Gly Val Asp Gln Ser Pro Lys Pro Leu Ile Ile Gly Pro Glu Glu
         435                 440                 445

 gac tat gac ccg ggt tat ttc aac aac gag agc gac atc ata ttc cag     1392
 Asp Tyr Asp Pro Gly Tyr Phe Asn Asn Glu Ser Asp Ile Ile Phe Gln
     450                 455                 460

 gat ctg gag aaa ctg aag tct cgg cca gct cac ctg ggg gtt ttt cta     1440
 Asp Leu Glu Lys Leu Lys Ser Arg Pro Ala His Leu Gly Val Phe Leu
 465                 470                 475                 480

 cgt tac atc ttc tct cag gcg gac ccc agt cca ctg ctt ttt tac ctg     1488
 Arg Tyr Ile Phe Ser Gln Ala Asp Pro Ser Pro Leu Leu Phe Tyr Leu
                 485                 490                 495

 tgt gca gaa gtt tat cag cag gca agc ccc aag gat tcc cga agc ttg     1536
 Cys Ala Glu Val Tyr Gln Gln Ala Ser Pro Lys Asp Ser Arg Ser Leu
             500                 505                 510

 ggg aaa gac atc tgg aat att ttc ctg gag aaa aat gcg cct ctg aga     1584
 Gly Lys Asp Ile Trp Asn Ile Phe Leu Glu Lys Asn Ala Pro Leu Arg
         515                 520                 525

 gtg aag atc cct gag atg cta cag gct gaa att gac tcg cgc ctg cgg     1632
 Val Lys Ile Pro Glu Met Leu Gln Ala Glu Ile Asp Ser Arg Leu Arg
     530                 535                 540

 aac agc gaa gat gcc cgt ggt gtt ctc tgt gaa gct caa gag gca gcc     1680
 Asn Ser Glu Asp Ala Arg Gly Val Leu Cys Glu Ala Gln Glu Ala Ala
 545                 550                 555                 560

 atg cct gag atc caa gag cag atc cac gac tac aga acg aag cgc aca     1728
 Met Pro Glu Ile Gln Glu Gln Ile His Asp Tyr Arg Thr Lys Arg Thr
                 565                 570                 575

 ctg ggg ctg ggc agc ctg tat ggt gaa aat gac ctg ctg gac ctg gat     1776
 Leu Gly Leu Gly Ser Leu Tyr Gly Glu Asn Asp Leu Leu Asp Leu Asp
             580                 585                 590

 ggg gac cct ctc cga gag cgc caa gtg gct gag aag cag ctg gct gcc     1824
 Gly Asp Pro Leu Arg Glu Arg Gln Val Ala Glu Lys Gln Leu Ala Ala
         595                 600                 605

 ctt gga gat att ttg tcc aag tat gag gaa gac agg agc gcc ccc atg     1872
 Leu Gly Asp Ile Leu Ser Lys Tyr Glu Glu Asp Arg Ser Ala Pro Met
     610                 615                 620

 gac ttc gcc ctc aat acc tac atg agc cat gct ggg atc cgt ctt cga     1920
 Asp Phe Ala Leu Asn Thr Tyr Met Ser His Ala Gly Ile Arg Leu Arg
 625                 630                 635                 640

 gag gca cga cct tcc aac aca gct gaa aag gcc cag tct gct cct gac     1968
 Glu Ala Arg Pro Ser Asn Thr Ala Glu Lys Ala Gln Ser Ala Pro Asp
                 645                 650                 655

 aag gac aag tgg cta ccg ttc ttc cct aag acc aag aag agc agc aat     2016
 Lys Asp Lys Trp Leu Pro Phe Phe Pro Lys Thr Lys Lys Ser Ser Asn
             660                 665                 670

 tcc aag aaa gaa aag gat gcc ttg gag gac aag aag cga aac cct atc     2064
 Ser Lys Lys Glu Lys Asp Ala Leu Glu Asp Lys Lys Arg Asn Pro Ile
         675                 680                 685

 ctc aaa tac att ggg aag ccc aaa agc tct tct caa agc ata tgt tgg     2112
 Leu Lys Tyr Ile Gly Lys Pro Lys Ser Ser Ser Gln Ser Ile Cys Trp
     690                 695                 700

 cag agg gcc ttc ctg tgt ttc tgg gag cca cag gcc caa act cag acc     2160
 Gln Arg Ala Phe Leu Cys Phe Trp Glu Pro Gln Ala Gln Thr Gln Thr
 705                 710                 715                 720

 aca gcc act ttc tcc cct tgc caa atc cag tgc agg atc tct gag gtt     2208
 Thr Ala Thr Phe Ser Pro Cys Gln Ile Gln Cys Arg Ile Ser Glu Val
                 725                 730                 735

 cag gtg aat gtt tcc gag cca ggg aag ccg tgc cgg tcc ctg ggt ctt     2256
 Gln Val Asn Val Ser Glu Pro Gly Lys Pro Cys Arg Ser Leu Gly Leu
             740                 745                 750

 agt cta gga acc cag agc agt tct agc tac caa acg acc acg aaa aac     2304
 Ser Leu Gly Thr Gln Ser Ser Ser Ser Tyr Gln Thr Thr Thr Lys Asn
         755                 760                 765

 cta atc atg act ttc aag cag aag cgt tat tat aat aat gtg aga gcc     2352
 Leu Ile Met Thr Phe Lys Gln Lys Arg Tyr Tyr Asn Asn Val Arg Ala
     770                 775                 780

 aaa aga atg ctt atg gaa aat ata ctt cca aac cct ctc att ttg cgc     2400
 Lys Arg Met Leu Met Glu Asn Ile Leu Pro Asn Pro Leu Ile Leu Arg
 785                 790                 795                 800

 atg agg aaa gaa tca acc cag aaa gtc aaa cca ggc aat gtg agg aac     2448
 Met Arg Lys Glu Ser Thr Gln Lys Val Lys Pro Gly Asn Val Arg Asn
                 805                 810                 815

 atc att cag cac ttt gag aac aac cag cag tat gat gcc cca gaa cct     2496
 Ile Ile Gln His Phe Glu Asn Asn Gln Gln Tyr Asp Ala Pro Glu Pro
             820                 825                 830

 ggg aca caa cga ctc tcg acc gga agc ttt cct gag gac ctg ctg gag     2544
 Gly Thr Gln Arg Leu Ser Thr Gly Ser Phe Pro Glu Asp Leu Leu Glu
         835                 840                 845

 agt gac agt tca cgc tca gag att cgc ctg ggc cgc tct gaa agc ctc     2592
 Ser Asp Ser Ser Arg Ser Glu Ile Arg Leu Gly Arg Ser Glu Ser Leu
     850                 855                 860

 aag ggc cgg gaa gag atg aaa cgg tct cga aag gca gag aac gtg ccc     2640
 Lys Gly Arg Glu Glu Met Lys Arg Ser Arg Lys Ala Glu Asn Val Pro
 865                 870                 875                 880

 cgc tct cgc agt gat gtt gac atg gat gct gct gcg gag gct act cgc     2688
 Arg Ser Arg Ser Asp Val Asp Met Asp Ala Ala Ala Glu Ala Thr Arg
                 885                 890                 895

 ctg cac cag tca gcc tcg tcc tct acc tcc agc ctc tcc acc agg agc     2736
 Leu His Gln Ser Ala Ser Ser Ser Thr Ser Ser Leu Ser Thr Arg Ser
             900                 905                 910

 att gag tcc ccc agt ttg ggg ttc tgc aca gat acc ctc ctt ccc cac     2784
 Ile Glu Ser Pro Ser Leu Gly Phe Cys Thr Asp Thr Leu Leu Pro His
         915                 920                 925

 ctc cta gag gat gat ctg ggc cag ctg tct gac ctg gag cca gag cca     2832
 Leu Leu Glu Asp Asp Leu Gly Gln Leu Ser Asp Leu Glu Pro Glu Pro
     930                 935                 940

 gat gcc caa aat tgg cag cat aca gtg ggc aag gat gtg gtg gct ggg     2880
 Asp Ala Gln Asn Trp Gln His Thr Val Gly Lys Asp Val Val Ala Gly
 945                 950                 955                 960

 cta acc cag cgg gag att gac cgg caa gag gtc atc aat gag ctg ttt     2928
 Leu Thr Gln Arg Glu Ile Asp Arg Gln Glu Val Ile Asn Glu Leu Phe
                 965                 970                 975

 gtg act gaa gct tcc cac ctg cgc aca ctc cgg gtc ctg gac ctg atc     2976
 Val Thr Glu Ala Ser His Leu Arg Thr Leu Arg Val Leu Asp Leu Ile
             980                 985                 990

 ttc tac cag cga atg aag aag gag aac ctg atg ccc cgg gag gag ctg     3024
 Phe Tyr Gln Arg Met Lys Lys Glu Asn Leu Met Pro Arg Glu Glu Leu
         995                1000                1005

 gcc cgg ctc ttc ccg aac ctg cct gaa ctc ata gag att cac aat tcc     3072
 Ala Arg Leu Phe Pro Asn Leu Pro Glu Leu Ile Glu Ile His Asn Ser
    1010                1015                1020

 tgg tgt gaa gcc atg aag aag ctc cgg gag gaa ggc ccc atc atc aaa     3120
 Trp Cys Glu Ala Met Lys Lys Leu Arg Glu Glu Gly Pro Ile Ile Lys
1025                1030                1035                1040

 gag atc agt gac ctc atg ctg gcc cgg ttt gat ggc cct gcc cga gag     3168
 Glu Ile Ser Asp Leu Met Leu Ala Arg Phe Asp Gly Pro Ala Arg Glu
                1045                1050                1055

 gaa ctc cag caa gtg gct gca cag ttc tgt tcc tat cag tca ata gcc     3216
 Glu Leu Gln Gln Val Ala Ala Gln Phe Cys Ser Tyr Gln Ser Ile Ala
            1060                1065                1070

 cta gag cta atc aag acc aag caa cgc aag gag agt cga ttc cag ctc     3264
 Leu Glu Leu Ile Lys Thr Lys Gln Arg Lys Glu Ser Arg Phe Gln Leu
        1075                1080                1085

 ttc atg cag gag gct gag agc cac cct cag tgt cgg cgg ctg cag ctg     3312
 Phe Met Gln Glu Ala Glu Ser His Pro Gln Cys Arg Arg Leu Gln Leu
    1090                1095                1100

 aga gac ctc atc atc tct gag atg cag cgg ctc acc aag tac ccg ctg     3360
 Arg Asp Leu Ile Ile Ser Glu Met Gln Arg Leu Thr Lys Tyr Pro Leu
1105                1110                1115                1120

 ctg ctg gag agc atc atc aag cac aca gag ggt ggc acc tct gag cat     3408
 Leu Leu Glu Ser Ile Ile Lys His Thr Glu Gly Gly Thr Ser Glu His
                1125                1130                1135

 gag aag ctg tgc cgg gcc cgg gac cag tgc cgg gag att ctc aag tat     3456
 Glu Lys Leu Cys Arg Ala Arg Asp Gln Cys Arg Glu Ile Leu Lys Tyr
            1140                1145                1150

 gtg aat gaa gcg gta aaa caa aca gag aac cgc cac cgt tta gag ggc     3504
 Val Asn Glu Ala Val Lys Gln Thr Glu Asn Arg His Arg Leu Glu Gly
        1155                1160                1165

 tac cag aaa cgc ctg gat gcc acc gcc ctg gag agg gcc agc aac ccc     3552
 Tyr Gln Lys Arg Leu Asp Ala Thr Ala Leu Glu Arg Ala Ser Asn Pro
    1170                1175                1180

 ctg gca gca gag ttc aag agc ctg gat ctt aca acc aga aaa atg atc     3600
 Leu Ala Ala Glu Phe Lys Ser Leu Asp Leu Thr Thr Arg Lys Met Ile
1185                1190                1195                1200

 cat gag gga ccc ctg acc tgg agg atc agc aag gat aag acc ttg gac     3648
 His Glu Gly Pro Leu Thr Trp Arg Ile Ser Lys Asp Lys Thr Leu Asp
                1205                1210                1215

 ctc cac gtg ctg ctg ctg gag gac ctc cta gtg ctg cta cag aaa cag     3696
 Leu His Val Leu Leu Leu Glu Asp Leu Leu Val Leu Leu Gln Lys Gln
            1220                1225                1230

 gat gag aag cta ttg ctg aag tgc cac agc aag act gct gtg ggc tcc     3744
 Asp Glu Lys Leu Leu Leu Lys Cys His Ser Lys Thr Ala Val Gly Ser
        1235                1240                1245

 tca gac agc aag cag acc ttc agc ccc gtg ctc aag ctc aat gct gtg     3792
 Ser Asp Ser Lys Gln Thr Phe Ser Pro Val Leu Lys Leu Asn Ala Val
    1250                1255                1260

 ctc atc cgc tct gtg gcc aca gat aaa cgg gcc ttc ttc atc atc tgc     3840
 Leu Ile Arg Ser Val Ala Thr Asp Lys Arg Ala Phe Phe Ile Ile Cys
1265                1270                1275                1280

 acc tcc aag ctg ggc cca ccc cag atc tat gag ctg gtt gca ttg acg     3888
 Thr Ser Lys Leu Gly Pro Pro Gln Ile Tyr Glu Leu Val Ala Leu Thr
                1285                1290                1295

 tca tca gac aag aac aca tgg atg gag ctc tta gaa gag gcc gtg cgg     3936
 Ser Ser Asp Lys Asn Thr Trp Met Glu Leu Leu Glu Glu Ala Val Arg
            1300                1305                1310

 aat gcc acc agg cac ccc gga gct gcc cca atg ccc gtc cat cct cca     3984
 Asn Ala Thr Arg His Pro Gly Ala Ala Pro Met Pro Val His Pro Pro
        1315                1320                1325

 ccc cca ggt ccc cgg gag cca gcc cag cag ggc ccc aca ccc agc agc     4032
 Pro Pro Gly Pro Arg Glu Pro Ala Gln Gln Gly Pro Thr Pro Ser Ser
    1330                1335                1340

 ctg cca cct ggc tat aat aga gct gag cct gaa gaa ggg gta gaa ctg     4080
 Leu Pro Pro Gly Tyr Asn Arg Ala Glu Pro Glu Glu Gly Val Glu Leu
1345                1350                1355                1360

 gat gac tca gac gtg ttc cat ggt gaa cct gaa cct gag gag ctg cct     4128
 Asp Asp Ser Asp Val Phe His Gly Glu Pro Glu Pro Glu Glu Leu Pro
                1365                1370                1375

 gga ggc act ggg tcc cag cag agg gtc caa ggg aag cac cag gtc ctg     4176
 Gly Gly Thr Gly Ser Gln Gln Arg Val Gln Gly Lys His Gln Val Leu
            1380                1385                1390

 cta gag gac cct gag cag gag ggc agt gca gag gaa gag gaa ctg ggt     4224
 Leu Glu Asp Pro Glu Gln Glu Gly Ser Ala Glu Glu Glu Glu Leu Gly
        1395                1400                1405

 gtc ctg cct tgc cct tcc aca tcc ctg gat gga gag aac agg ggc atc     4272
 Val Leu Pro Cys Pro Ser Thr Ser Leu Asp Gly Glu Asn Arg Gly Ile
    1410                1415                1420

 agg aca agg aac ccc atc cac ttg gcc ttc cca ggc cct ctg ttc atg     4320
 Arg Thr Arg Asn Pro Ile His Leu Ala Phe Pro Gly Pro Leu Phe Met
1425                1430                1435                1440

 gaa ggg ctc gct gac tcc gct ctg gaa gat gtg gag aac ctg cga cat     4368
 Glu Gly Leu Ala Asp Ser Ala Leu Glu Asp Val Glu Asn Leu Arg His
                1445                1450                1455

 ctg atc ctg tgg agc ctg ctg cca ggt cac acc atg gaa act cag gct     4416
 Leu Ile Leu Trp Ser Leu Leu Pro Gly His Thr Met Glu Thr Gln Ala
            1460                1465                1470

 gcc cag gag ccc gag gac gac ctg aca ccc aca cct tct gtc atc agc     4464
 Ala Gln Glu Pro Glu Asp Asp Leu Thr Pro Thr Pro Ser Val Ile Ser
        1475                1480                1485

 gtc acc tct cac ccc tgg gac cca ggc tcc cca ggg caa gca ccc cct     4512
 Val Thr Ser His Pro Trp Asp Pro Gly Ser Pro Gly Gln Ala Pro Pro
    1490                1495                1500

 ggg ggt gaa ggg gac aac acc cag ctt gca ggg ctg gag ggg gaa cgg     4560
 Gly Gly Glu Gly Asp Asn Thr Gln Leu Ala Gly Leu Glu Gly Glu Arg
1505                1510                1515                1520

 cca gag cag gaa gac atg ggt ctc tgt tct ctg gaa cac cta ccc cca     4608
 Pro Glu Gln Glu Asp Met Gly Leu Cys Ser Leu Glu His Leu Pro Pro
                1525                1530                1535

 agg acc aga aat tct ggg ata tgg gag tct cca gaa ctg gac agg aat     4656
 Arg Thr Arg Asn Ser Gly Ile Trp Glu Ser Pro Glu Leu Asp Arg Asn
            1540                1545                1550

 ctg gct gaa gat gct tca agc aca gag gca gca gga ggt tac aaa gtt     4704
 Leu Ala Glu Asp Ala Ser Ser Thr Glu Ala Ala Gly Gly Tyr Lys Val
        1555                1560                1565

 gtg aga aaa ggg aac tgc ttt tat gtc agc atg cca tca gga ccc ccg     4752
 Val Arg Lys Gly Asn Cys Phe Tyr Val Ser Met Pro Ser Gly Pro Pro
    1570                1575                1580

 gac tca agc acc gac cac tca gag gca ccc atg agc ccc cct cag cct     4800
 Asp Ser Ser Thr Asp His Ser Glu Ala Pro Met Ser Pro Pro Gln Pro
1585                1590                1595                1600

 gac agc ctc cct gca ggg cag aca gag cct cag cct cag ctg cag gga     4848
 Asp Ser Leu Pro Ala Gly Gln Thr Glu Pro Gln Pro Gln Leu Gln Gly
                1605                1610                1615

 ggc aac gat gat cca aga cgc ccc agc cgc tct cct cca agc ctg gcc     4896
 Gly Asn Asp Asp Pro Arg Arg Pro Ser Arg Ser Pro Pro Ser Leu Ala
            1620                1625                1630

 ctc agg gac gtg ggc atg atc ttc cat acc att gag cag ctc act ctc     4944
 Leu Arg Asp Val Gly Met Ile Phe His Thr Ile Glu Gln Leu Thr Leu
        1635                1640                1645

 aag ctc aac agg ctc aag gat atg gag ctg gcc cac aga gag ctg ctc     4992
 Lys Leu Asn Arg Leu Lys Asp Met Glu Leu Ala His Arg Glu Leu Leu
    1650                1655                1660

 aag tcc ctt ggg gga gag tca tct ggt ggc acc acg cct gtg ggc agt     5040
 Lys Ser Leu Gly Gly Glu Ser Ser Gly Gly Thr Thr Pro Val Gly Ser
1665                1670                1675                1680

 ttc cac aca gaa gca gct aga tgg aca gat ggc tcc ctc tca cct ccc     5088
 Phe His Thr Glu Ala Ala Arg Trp Thr Asp Gly Ser Leu Ser Pro Pro
                1685                1690                1695

 gct aag gag ccc cta gct tct gac tcc agg aac agc cat gaa ctg ggg     5136
 Ala Lys Glu Pro Leu Ala Ser Asp Ser Arg Asn Ser His Glu Leu Gly
            1700                1705                1710

 ccc tgc cct gag gat ggc tct gac gcc ccc ctg gaa gac agc aca gca     5184
 Pro Cys Pro Glu Asp Gly Ser Asp Ala Pro Leu Glu Asp Ser Thr Ala
        1715                1720                1725

 gac gca gcc gcg tca cca gga cca taa                                 5211
 Asp Ala Ala Ala Ser Pro Gly Pro 
    1730                1735





      <210> 648
      <211> 1398
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (1)..(1398)

      <400> 648
  atg ttg cat atc gtc atg ttt agc ctt tct atc ctg tct cag aaa gaa      48
  Met Leu His Ile Val Met Phe Ser Leu Ser Ile Leu Ser Gln Lys Glu
    1               5                  10                  15

 aag gaa gct gga ggc ttc ccc ttg aag gga ctg gat agg cag tta gag       96
 Lys Glu Ala Gly Gly Phe Pro Leu Lys Gly Leu Asp Arg Gln Leu Glu
              20                  25                  30

 agt gcc aga ggc cca aat gct ctt cag tca gct tat gat gaa tgc tgc      144
 Ser Ala Arg Gly Pro Asn Ala Leu Gln Ser Ala Tyr Asp Glu Cys Cys
          35                  40                  45

 cag gcc tgg gac tct ccc ttc agg gta gta ggc ttc ccc aac ccc tgg      192
 Gln Ala Trp Asp Ser Pro Phe Arg Val Val Gly Phe Pro Asn Pro Trp
      50                  55                  60

 ccc agg aca ggt cca gaa atg cca tcc aag agc caa ggc cta gaa ctg      240
 Pro Arg Thr Gly Pro Glu Met Pro Ser Lys Ser Gln Gly Leu Glu Leu
  65                  70                  75                  80

 agg acc cta aga gcc cac ttg gtg ctc tac cct act gtg gct gag ctg      288
 Arg Thr Leu Arg Ala His Leu Val Leu Tyr Pro Thr Val Ala Glu Leu
                  85                  90                  95

 ctg cct aag ctg caa gac aaa gtg tcc ttt act ctt ttc tct cct ttt      336
 Leu Pro Lys Leu Gln Asp Lys Val Ser Phe Thr Leu Phe Ser Pro Phe
             100                 105                 110

 ctc aag cag gag tcc ctc ccc att gct acc aca gtt agg aaa cat ctg      384
 Leu Lys Gln Glu Ser Leu Pro Ile Ala Thr Thr Val Arg Lys His Leu
         115                 120                 125

 tat gga tta ttt cac tat aat cct atg atg ctt gga ctt gaa tca ctt      432
 Tyr Gly Leu Phe His Tyr Asn Pro Met Met Leu Gly Leu Glu Ser Leu
     130                 135                 140

 cca gat ccc aca gac acc tgg gaa att ata gag acc att ggt aaa ggc      480
 Pro Asp Pro Thr Asp Thr Trp Glu Ile Ile Glu Thr Ile Gly Lys Gly
 145                 150                 155                 160

 acc tat ggc aaa gtc tac aag gta act aac aag aga gat ggg agc ctg      528
 Thr Tyr Gly Lys Val Tyr Lys Val Thr Asn Lys Arg Asp Gly Ser Leu
                 165                 170                 175

 gct gca gtg aaa att ctg gat cca gtc agt gat atg gat gaa gaa att      576
 Ala Ala Val Lys Ile Leu Asp Pro Val Ser Asp Met Asp Glu Glu Ile
             180                 185                 190

 gag gca gaa tac aac att ttg cag ttc ctt cct aat cat ccc aat gtt      624
 Glu Ala Glu Tyr Asn Ile Leu Gln Phe Leu Pro Asn His Pro Asn Val
         195                 200                 205

 gta aag ttt tat ggg atg ttt tac aaa gcg gat cac tgt gta ggg gga      672
 Val Lys Phe Tyr Gly Met Phe Tyr Lys Ala Asp His Cys Val Gly Gly
     210                 215                 220

 cag ctg tgg ctg gtc ctg gag ggg aaa aca gtc aga tct ccc tca gag      720
 Gln Leu Trp Leu Val Leu Glu Gly Lys Thr Val Arg Ser Pro Ser Glu
 225                 230                 235                 240

 gcc tat cta agg gtt gct ggc caa agg ggc cat cat ccg agg ctc cag      768
 Ala Tyr Leu Arg Val Ala Gly Gln Arg Gly His His Pro Arg Leu Gln
                 245                 250                 255

 ttg cat gac cat ttg gag ttt gat gtc atg aag ctg tgt aat ggg ggc      816
 Leu His Asp His Leu Glu Phe Asp Val Met Lys Leu Cys Asn Gly Gly
             260                 265                 270

 tca gtc act gag ctt gtc aaa ggt cta ctc aga tgt ggc cag cgg ttg      864
 Ser Val Thr Glu Leu Val Lys Gly Leu Leu Arg Cys Gly Gln Arg Leu
         275                 280                 285

 gat gaa gca atg atc tca tac atc ttg tac ggg gcc ctc ttg gta aga      912
 Asp Glu Ala Met Ile Ser Tyr Ile Leu Tyr Gly Ala Leu Leu Val Arg
     290                 295                 300

 aca tct atc aaa tgg ggt gtt tca gct caa ctc acc agt aca cgt ctg      960
 Thr Ser Ile Lys Trp Gly Val Ser Ala Gln Leu Thr Ser Thr Arg Leu
 305                 310                 315                 320

 cgg aga aac aca tct gtt ggc acc ccg ttc tgg atg gcc cct gag ggc     1008
 Arg Arg Asn Thr Ser Val Gly Thr Pro Phe Trp Met Ala Pro Glu Gly
                 325                 330                 335

 agt tat gac aac agt gcc tgt gaa tat ctg agg ggc agt agt ggc tcc     1056
 Ser Tyr Asp Asn Ser Ala Cys Glu Tyr Leu Arg Gly Ser Ser Gly Ser
             340                 345                 350

 aac atg cca ata gcc aca ggt gaa ggc act cat ggt gca acc aaa cag     1104
 Asn Met Pro Ile Ala Thr Gly Glu Gly Thr His Gly Ala Thr Lys Gln
         355                 360                 365

 cga gaa gtt aaa gtc att gcc tgt gag cag cag tat gac tct tcc tat     1152
 Arg Glu Val Lys Val Ile Ala Cys Glu Gln Gln Tyr Asp Ser Ser Tyr
     370                 375                 380

 gac gct cgc tgt gac gtc tgg tcc ttg ggg atc aca gct att gaa ctg     1200
 Asp Ala Arg Cys Asp Val Trp Ser Leu Gly Ile Thr Ala Ile Glu Leu
 385                 390                 395                 400

 ggg gat gga gac cct ccc ctc ttt gac atg cat cct gtg aaa aca ctc     1248
 Gly Asp Gly Asp Pro Pro Leu Phe Asp Met His Pro Val Lys Thr Leu
                 405                 410                 415

 ttt aag att cca aga tgt gaa caa cca cca acc act att cca aaa atg     1296
 Phe Lys Ile Pro Arg Cys Glu Gln Pro Pro Thr Thr Ile Pro Lys Met
             420                 425                 430

 att ccc acc caa gcc aga gtt agt ctt ttt gcc ttt ttc gaa tca caa     1344
 Ile Pro Thr Gln Ala Arg Val Ser Leu Phe Ala Phe Phe Glu Ser Gln
         435                 440                 445

 aaa cag gtc aca gcg att aga gga gca gac gaa gca cct ggc ttt tta     1392
 Lys Gln Val Thr Ala Ile Arg Gly Ala Asp Glu Ala Pro Gly Phe Leu
     450                 455                 460

 aat taa                                                             1398
 Asn 
 465





      <210> 649
      <211> 3207
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (1)..(3207)

      <400> 649
  atg gga atg gag gcc cgc tgc agg gtg gcg ctt cct cta gtg tcg ccc      48
  Met Gly Met Glu Ala Arg Cys Arg Val Ala Leu Pro Leu Val Ser Pro
    1               5                  10                  15

 agt gtg ctc caa gca ttt cac ttc tat tac ttc ctg tac tcc tca ctg       96
 Ser Val Leu Gln Ala Phe His Phe Tyr Tyr Phe Leu Tyr Ser Ser Leu
              20                  25                  30

 aaa ccc agc gag gaa gac cct gtg atc agg gtg tca cgg atg agg aag      144
 Lys Pro Ser Glu Glu Asp Pro Val Ile Arg Val Ser Arg Met Arg Lys
          35                  40                  45

 ctg ggg ctt cag agt aga gcc aag aaa gat cac aat gag gac cta ggg      192
 Leu Gly Leu Gln Ser Arg Ala Lys Lys Asp His Asn Glu Asp Leu Gly
      50                  55                  60

 cat ctg tct gct gac gcc ccc tgg cct gca gtg acc atg gcc ccc cgc      240
 His Leu Ser Ala Asp Ala Pro Trp Pro Ala Val Thr Met Ala Pro Arg
  65                  70                  75                  80

 aag agg agc cac cat ggc ctg ggc ttc ctg tgc tgc ttc ggg ggc agt      288
 Lys Arg Ser His His Gly Leu Gly Phe Leu Cys Cys Phe Gly Gly Ser
                  85                  90                  95

 gac atc ccc gaa atc aac ctc cgg gac aac cac cct ctg cag ttc atg      336
 Asp Ile Pro Glu Ile Asn Leu Arg Asp Asn His Pro Leu Gln Phe Met
             100                 105                 110

 gag ttc tcc agc ccc atc ccg aac gca gag gag ctc aac atc cgc ttt      384
 Glu Phe Ser Ser Pro Ile Pro Asn Ala Glu Glu Leu Asn Ile Arg Phe
         115                 120                 125

 gca gag ctg gtg gat gaa ttg gat ctc act gac aaa aac cga gag gct      432
 Ala Glu Leu Val Asp Glu Leu Asp Leu Thr Asp Lys Asn Arg Glu Ala
     130                 135                 140

 atg ttt gca ctg ccc cct gag aag aaa tgg cag atc tac tgc agc aag      480
 Met Phe Ala Leu Pro Pro Glu Lys Lys Trp Gln Ile Tyr Cys Ser Lys
 145                 150                 155                 160

 aag aag gag cag gag gac ccc aac aag ctg gca acc agc tgg cct gac      528
 Lys Lys Glu Gln Glu Asp Pro Asn Lys Leu Ala Thr Ser Trp Pro Asp
                 165                 170                 175

 tat tac atc gac cgc atc aat tcc atg gct gcg atg cag agt ctg tac      576
 Tyr Tyr Ile Asp Arg Ile Asn Ser Met Ala Ala Met Gln Ser Leu Tyr
             180                 185                 190

 gcg ttt gat gag gag gag acg gag atg agg aac caa gtc gtg gaa gac      624
 Ala Phe Asp Glu Glu Glu Thr Glu Met Arg Asn Gln Val Val Glu Asp
         195                 200                 205

 ctg aag aca gcc ctc cgg aca cag cct atg agg ttt gtg acc cgc ttc      672
 Leu Lys Thr Ala Leu Arg Thr Gln Pro Met Arg Phe Val Thr Arg Phe
     210                 215                 220

 att gag ctg gag ggc ttg acc tgt ctg cta aat ttc ctc cgg agc atg      720
 Ile Glu Leu Glu Gly Leu Thr Cys Leu Leu Asn Phe Leu Arg Ser Met
 225                 230                 235                 240

 gac cac gcc acc tgt gag agc cgc atc cac acc tca ctc att ggc tgc      768
 Asp His Ala Thr Cys Glu Ser Arg Ile His Thr Ser Leu Ile Gly Cys
                 245                 250                 255

 atc aaa gca ttg atg aac aac tcc cag ggg cgg gca cat gtg ctg gca      816
 Ile Lys Ala Leu Met Asn Asn Ser Gln Gly Arg Ala His Val Leu Ala
             260                 265                 270

 cag cct gag gcc att agt acc ata gcc cag agc cta cgc aca gag aac      864
 Gln Pro Glu Ala Ile Ser Thr Ile Ala Gln Ser Leu Arg Thr Glu Asn
         275                 280                 285

 agc aag acc aag gtg gct gtg ctg gag atc ctg ggt gct gtg tgc ctc      912
 Ser Lys Thr Lys Val Ala Val Leu Glu Ile Leu Gly Ala Val Cys Leu
     290                 295                 300

 gtg cct ggt ggc cac aag aag gtg ctg cag gcc atg ctg cac tac cag      960
 Val Pro Gly Gly His Lys Lys Val Leu Gln Ala Met Leu His Tyr Gln
 305                 310                 315                 320

 gtg tat gca gca gag cga acc cgc ttc cag acc ctg ctg aac gag cta     1008
 Val Tyr Ala Ala Glu Arg Thr Arg Phe Gln Thr Leu Leu Asn Glu Leu
                 325                 330                 335

 gac cga agt ctg ggc cgg tac cgg gat gaa gtg aat ctg aaa aca gcc     1056
 Asp Arg Ser Leu Gly Arg Tyr Arg Asp Glu Val Asn Leu Lys Thr Ala
             340                 345                 350

 atc atg tcc ttc atc aat gct gtc ctc aat gct gga gct gga gag gat     1104
 Ile Met Ser Phe Ile Asn Ala Val Leu Asn Ala Gly Ala Gly Glu Asp
         355                 360                 365

 aat ctg gag ttc cgc cta cat cta cgg tat gaa ttc ctg atg ctg ggt     1152
 Asn Leu Glu Phe Arg Leu His Leu Arg Tyr Glu Phe Leu Met Leu Gly
     370                 375                 380

 ata cag cct gtg att gac aag ctc cgg caa cat gaa aat gcc atc ctg     1200
 Ile Gln Pro Val Ile Asp Lys Leu Arg Gln His Glu Asn Ala Ile Leu
 385                 390                 395                 400

 gac aaa cat tta gac ttc ttc gag atg gtg cgg aat gag gat gac ctg     1248
 Asp Lys His Leu Asp Phe Phe Glu Met Val Arg Asn Glu Asp Asp Leu
                 405                 410                 415

 gag cta gcc agg agg ttt gac atg gtc cac atc gac acc aag agt gct     1296
 Glu Leu Ala Arg Arg Phe Asp Met Val His Ile Asp Thr Lys Ser Ala
             420                 425                 430

 tcc cag atg ttt gag ttg atc cac aag aag ctg aag tac acg gag gcc     1344
 Ser Gln Met Phe Glu Leu Ile His Lys Lys Leu Lys Tyr Thr Glu Ala
         435                 440                 445

 tac ccc tgc ctg ctc tct gtg ctg cac cac tgc ctg cag atg ccc tac     1392
 Tyr Pro Cys Leu Leu Ser Val Leu His His Cys Leu Gln Met Pro Tyr
     450                 455                 460

 aaa cgg aac ggt ggc tac ttc cag cag tgg cag ctc ctg gac cgc atc     1440
 Lys Arg Asn Gly Gly Tyr Phe Gln Gln Trp Gln Leu Leu Asp Arg Ile
 465                 470                 475                 480

 ctc cag cag att gtc ctc cag gat gag cgg ggt gtg gac cct gac ctg     1488
 Leu Gln Gln Ile Val Leu Gln Asp Glu Arg Gly Val Asp Pro Asp Leu
                 485                 490                 495

 gct ccc ttg gag aac ttc aat gtc aag aac atc gtc aac atg ctc atc     1536
 Ala Pro Leu Glu Asn Phe Asn Val Lys Asn Ile Val Asn Met Leu Ile
             500                 505                 510

 aac gag aat gaa gtg aaa cag tgg cga gac cag gca gag aag ttc cgg     1584
 Asn Glu Asn Glu Val Lys Gln Trp Arg Asp Gln Ala Glu Lys Phe Arg
         515                 520                 525

 aaa gaa cac atg gag ctt gtg agc cgt ctg gag agg aag gag cgg gaa     1632
 Lys Glu His Met Glu Leu Val Ser Arg Leu Glu Arg Lys Glu Arg Glu
     530                 535                 540

 tgc gag aca aag aca ttg gag aag gaa gag atg atg cgg acg ctg aac     1680
 Cys Glu Thr Lys Thr Leu Glu Lys Glu Glu Met Met Arg Thr Leu Asn
 545                 550                 555                 560

 aaa atg aag gac aag ctg gcc cgg gag tcc cag gag ctg cgc cag gct     1728
 Lys Met Lys Asp Lys Leu Ala Arg Glu Ser Gln Glu Leu Arg Gln Ala
                 565                 570                 575

 cgg gga caa gtg gca gag ctg gac ccc tac ccc agc agt gac gtc cca     1776
 Arg Gly Gln Val Ala Glu Leu Asp Pro Tyr Pro Ser Ser Asp Val Pro
             580                 585                 590

 ctc agg aaa aag cgt gtc ccc cag cct tct cac cca ctg aag tcc ttc     1824
 Leu Arg Lys Lys Arg Val Pro Gln Pro Ser His Pro Leu Lys Ser Phe
         595                 600                 605

 aac tgg gtg aag ctg aat gag gag cgt gtc cct ggc acc gta tgg aat     1872
 Asn Trp Val Lys Leu Asn Glu Glu Arg Val Pro Gly Thr Val Trp Asn
     610                 615                 620

 gag att gat gac atg cag gta ttt cgg atc ctg gac cta gag gat ttt     1920
 Glu Ile Asp Asp Met Gln Val Phe Arg Ile Leu Asp Leu Glu Asp Phe
 625                 630                 635                 640

 gaa aaa atg ttt tca gcc tac cag agg cac cag aaa gag ctg ggc tcc     1968
 Glu Lys Met Phe Ser Ala Tyr Gln Arg His Gln Lys Glu Leu Gly Ser
                 645                 650                 655

 act gaa gac atc tac ctg gct tcc cgc aag gtc aaa gag ctg tcg gtc     2016
 Thr Glu Asp Ile Tyr Leu Ala Ser Arg Lys Val Lys Glu Leu Ser Val
             660                 665                 670

 att gat ggc cgg agg gcc caa aac tgc atc atc ctt ctt tcc aag ttg     2064
 Ile Asp Gly Arg Arg Ala Gln Asn Cys Ile Ile Leu Leu Ser Lys Leu
         675                 680                 685

 aag ctt tct aac gag gag atc cgg cag gcc atc ttg aag atg gat gag     2112
 Lys Leu Ser Asn Glu Glu Ile Arg Gln Ala Ile Leu Lys Met Asp Glu
     690                 695                 700

 cag gag gac ctt gct aag gac atg ctg gag cag ctc ctc aag ttc atc     2160
 Gln Glu Asp Leu Ala Lys Asp Met Leu Glu Gln Leu Leu Lys Phe Ile
 705                 710                 715                 720

 cca gag aag agt gac att gac ctc ctg gag gag cac aag cat gaa att     2208
 Pro Glu Lys Ser Asp Ile Asp Leu Leu Glu Glu His Lys His Glu Ile
                 725                 730                 735

 gag cgg atg gcc cgt gct gac cgc ttc ctc tat gaa atg agc agg att     2256
 Glu Arg Met Ala Arg Ala Asp Arg Phe Leu Tyr Glu Met Ser Arg Ile
             740                 745                 750

 gac cac tac cag cag cga ctg caa gcc ctc ttc ttc aag aag aaa ttc     2304
 Asp His Tyr Gln Gln Arg Leu Gln Ala Leu Phe Phe Lys Lys Lys Phe
         755                 760                 765

 cag gag cgg ctg gct gag gca aag ccc aaa gtg gaa gcc atc ctg ttg     2352
 Gln Glu Arg Leu Ala Glu Ala Lys Pro Lys Val Glu Ala Ile Leu Leu
     770                 775                 780

 gcc tcc cgg gag ctg gtc cgc agc aag cgt ctt aga cag atg cta gag     2400
 Ala Ser Arg Glu Leu Val Arg Ser Lys Arg Leu Arg Gln Met Leu Glu
 785                 790                 795                 800

 gtc atc cta gcc ata ggc aac ttc atg aac aaa ggg cag cgt ggg ggc     2448
 Val Ile Leu Ala Ile Gly Asn Phe Met Asn Lys Gly Gln Arg Gly Gly
                 805                 810                 815

 gcc tac ggg ttc cgg gtg gcc agc ctc aac aag att gct gac acc aag     2496
 Ala Tyr Gly Phe Arg Val Ala Ser Leu Asn Lys Ile Ala Asp Thr Lys
             820                 825                 830

 tcc agc atc gac aga aac atc tct ctg ctc cat tac ctg atc atg atc     2544
 Ser Ser Ile Asp Arg Asn Ile Ser Leu Leu His Tyr Leu Ile Met Ile
         835                 840                 845

 ctg gag aag cat ttt cct gat att cta aac atg cct tca gag ctg caa     2592
 Leu Glu Lys His Phe Pro Asp Ile Leu Asn Met Pro Ser Glu Leu Gln
     850                 855                 860

 cat ctt cca gaa gcc gcc aaa gtc aac cta gca gaa ctg gag aag gag     2640
 His Leu Pro Glu Ala Ala Lys Val Asn Leu Ala Glu Leu Glu Lys Glu
 865                 870                 875                 880

 gtg ggc aac ctc agg agg ggc ctg aga gcg gtg gag gtg gag ctg gag     2688
 Val Gly Asn Leu Arg Arg Gly Leu Arg Ala Val Glu Val Glu Leu Glu
                 885                 890                 895

 tat cag agg cgc cag gta cgg gag ccc agt gac aag ttt gtc cct gtc     2736
 Tyr Gln Arg Arg Gln Val Arg Glu Pro Ser Asp Lys Phe Val Pro Val
             900                 905                 910

 atg agc gac ttc atc acg gtg tcc agc ttc agc ttc tcc gag ctg gag     2784
 Met Ser Asp Phe Ile Thr Val Ser Ser Phe Ser Phe Ser Glu Leu Glu
         915                 920                 925

 gac cag cta aat gag gcc agg gac aag ttc gcc aag gcc ttg atg cac     2832
 Asp Gln Leu Asn Glu Ala Arg Asp Lys Phe Ala Lys Ala Leu Met His
     930                 935                 940

 ttc ggg gag cat gac agc aag atg cag cca gac gaa ttc ttt ggc atc     2880
 Phe Gly Glu His Asp Ser Lys Met Gln Pro Asp Glu Phe Phe Gly Ile
 945                 950                 955                 960

 ttt gat acc ttc ttg cag gcc ttc tca gag gcc cgg cag gat cta gag     2928
 Phe Asp Thr Phe Leu Gln Ala Phe Ser Glu Ala Arg Gln Asp Leu Glu
                 965                 970                 975

 gcc atg agg agg agg aag gag gag gag gag cgg cgg gcg cgc atg gaa     2976
 Ala Met Arg Arg Arg Lys Glu Glu Glu Glu Arg Arg Ala Arg Met Glu
             980                 985                 990

 gcc atg ctg aag gag cag agg gaa cgt gag cgg tgg cag cgg cag cgg     3024
 Ala Met Leu Lys Glu Gln Arg Glu Arg Glu Arg Trp Gln Arg Gln Arg
         995                1000                1005

 aag gtc ctg gct gca ggc agc tcg ctg gag gag gga gga gag ttc gat     3072
 Lys Val Leu Ala Ala Gly Ser Ser Leu Glu Glu Gly Gly Glu Phe Asp
    1010                1015                1020

 gac ctg gtg tcg gcc ctg cgc tct ggg gag gtc ttc gac aag gac tta     3120
 Asp Leu Val Ser Ala Leu Arg Ser Gly Glu Val Phe Asp Lys Asp Leu
1025                1030                1035                1040

 tgc aag ctc aag cgc agc cgc aag cga tca ggg agc cag gcc ctg gaa     3168
 Cys Lys Leu Lys Arg Ser Arg Lys Arg Ser Gly Ser Gln Ala Leu Glu
                1045                1050                1055

 gtt acc cgg gag cgg gca ata aac cgg cta aat tat tga                 3207
 Val Thr Arg Glu Arg Ala Ile Asn Arg Leu Asn Tyr 
            1060                1065





      <210> 650
      <211> 1332
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (1)..(1332)

      <400> 650
  atg cca gct gtg gca tat gcc ttg gga gct aag tgg ctg ctg cac ttg      48
  Met Pro Ala Val Ala Tyr Ala Leu Gly Ala Lys Trp Leu Leu His Leu
    1               5                  10                  15

 acc act atg aag act ggt gtg gaa ggg tcc ttc tgg atg tac ttg ggc       96
 Thr Thr Met Lys Thr Gly Val Glu Gly Ser Phe Trp Met Tyr Leu Gly
              20                  25                  30

 agg gtc ccc aac gcc gga gcc atg gaa cta tca gca gca gca tta gat      144
 Arg Val Pro Asn Ala Gly Ala Met Glu Leu Ser Ala Ala Ala Leu Asp
          35                  40                  45

 tct cat agg agc atg cac ccc att gtg aac cat gca tgt gag gga tct      192
 Ser His Arg Ser Met His Pro Ile Val Asn His Ala Cys Glu Gly Ser
      50                  55                  60

 acg ttg cgc tgt ccc tat gag aat cta atg cct gat gct ctg tca ctt      240
 Thr Leu Arg Cys Pro Tyr Glu Asn Leu Met Pro Asp Ala Leu Ser Leu
  65                  70                  75                  80

 tct cca ata tta tct tca agc cca gct cat cgg gct ctg agg gac ctc      288
 Ser Pro Ile Leu Ser Ser Ser Pro Ala His Arg Ala Leu Arg Asp Leu
                  85                  90                  95

 tcc agg cca agc tct tac ctc acg gag gct tct cca ggt cgt ttc tcc      336
 Ser Arg Pro Ser Ser Tyr Leu Thr Glu Ala Ser Pro Gly Arg Phe Ser
             100                 105                 110

 ctg tct tca ggc agt ggt gac aga ctc tcc aag cga cga tct ggc ctg      384
 Leu Ser Ser Gly Ser Gly Asp Arg Leu Ser Lys Arg Arg Ser Gly Leu
         115                 120                 125

 aca ctt gct tct gtg ggc cat gtg atc act cac act ggc ctc ttt agg      432
 Thr Leu Ala Ser Val Gly His Val Ile Thr His Thr Gly Leu Phe Arg
     130                 135                 140

 atc agg gga tgc ctc tcc aca ggc cga gat cct gcc tgt tgt agg ccc      480
 Ile Arg Gly Cys Leu Ser Thr Gly Arg Asp Pro Ala Cys Cys Arg Pro
 145                 150                 155                 160

 ctt cag gat gcg ccg ctg cct gac agt gga ccc tcc agg cct aga tgt      528
 Leu Gln Asp Ala Pro Leu Pro Asp Ser Gly Pro Ser Arg Pro Arg Cys
                 165                 170                 175

 tac gtg atc atg gcc tct gca ggg ctg tgc atg aaa tcg gga tca aga      576
 Tyr Val Ile Met Ala Ser Ala Gly Leu Cys Met Lys Ser Gly Ser Arg
             180                 185                 190

 gct ctt tgc tca gga ggc aga tcc ctc acg agg ccc aaa gct gtg cgg      624
 Ala Leu Cys Ser Gly Gly Arg Ser Leu Thr Arg Pro Lys Ala Val Arg
         195                 200                 205

 aca cct cca tcc tct cag tgg gag gaa act ggc aaa tgc aca ggc ggc      672
 Thr Pro Pro Ser Ser Gln Trp Glu Glu Thr Gly Lys Cys Thr Gly Gly
     210                 215                 220

 gca gcc aag gtg cag acg ctc cac caa gct tgg cag ggg aca gcc aat      720
 Ala Ala Lys Val Gln Thr Leu His Gln Ala Trp Gln Gly Thr Ala Asn
 225                 230                 235                 240

 cct agg aat ttc cct tct gct gaa aag gca gca atc ttt cct agg gcg      768
 Pro Arg Asn Phe Pro Ser Ala Glu Lys Ala Ala Ile Phe Pro Arg Ala
                 245                 250                 255

 aac aaa cag aat gtg gtt aca gaa agt gaa gag gca gga ttc caa ccc      816
 Asn Lys Gln Asn Val Val Thr Glu Ser Glu Glu Ala Gly Phe Gln Pro
             260                 265                 270

 tgg cag acg gac tcc aga gct gtg ctc tcc acc ttg gcc acc cag ccc      864
 Trp Gln Thr Asp Ser Arg Ala Val Leu Ser Thr Leu Ala Thr Gln Pro
         275                 280                 285

 cct gca aga gcc cga gtg gga aac aga aag acc tgg caa tgt ccc cca      912
 Pro Ala Arg Ala Arg Val Gly Asn Arg Lys Thr Trp Gln Cys Pro Pro
     290                 295                 300

 acc ctc acc tca tgt atg gaa gag gct cct ggt tct gct act cca ctt      960
 Thr Leu Thr Ser Cys Met Glu Glu Ala Pro Gly Ser Ala Thr Pro Leu
 305                 310                 315                 320

 gct cag tct gtt gaa gga aag aaa aga tgt ttt aat gtc ctt gaa gtt     1008
 Ala Gln Ser Val Glu Gly Lys Lys Arg Cys Phe Asn Val Leu Glu Val
                 325                 330                 335

 gac ctg gaa aaa caa agc agg cgt gag ttt aag gca aca ggt cca gtc     1056
 Asp Leu Glu Lys Gln Ser Arg Arg Glu Phe Lys Ala Thr Gly Pro Val
             340                 345                 350

 ccc atc att gca gga cat gtg cca tgc ctg acc gtg gcc ggg ttt act     1104
 Pro Ile Ile Ala Gly His Val Pro Cys Leu Thr Val Ala Gly Phe Thr
         355                 360                 365

 gct cca ctg ctg ctc cac ttt atc ccc gtg gca gtc ttc aca gac ctt     1152
 Ala Pro Leu Leu Leu His Phe Ile Pro Val Ala Val Phe Thr Asp Leu
     370                 375                 380

 tcc ttg gga tcc cac act gag tcc tac ttt ggc agc gag agg cag ttt     1200
 Ser Leu Gly Ser His Thr Glu Ser Tyr Phe Gly Ser Glu Arg Gln Phe
 385                 390                 395                 400

 cct agc act tct ctg ccc tct cta gag ctg cag gtt tca gtc atc agt     1248
 Pro Ser Thr Ser Leu Pro Ser Leu Glu Leu Gln Val Ser Val Ile Ser
                 405                 410                 415

 gcc tat tcc tct ggt ctt cca act gta gct gta tcc agc tca ttc cct     1296
 Ala Tyr Ser Ser Gly Leu Pro Thr Val Ala Val Ser Ser Ser Phe Pro
             420                 425                 430

 act cct att gta aac aac gtg tcc agt ata caa taa                     1332
 Thr Pro Ile Val Asn Asn Val Ser Ser Ile Gln 
         435                 440





      <210> 651
      <211> 2934
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (1)..(2934)

      <400> 651
  atg cac cta gga aca ttg ttg ctt cag gac cag tta ttt ctg acc ttc      48
  Met His Leu Gly Thr Leu Leu Leu Gln Asp Gln Leu Phe Leu Thr Phe
    1               5                  10                  15

 cag ttg ttc ctg act gtg aag ggt gac cgc ttt ccg gaa tcg ggc agg       96
 Gln Leu Phe Leu Thr Val Lys Gly Asp Arg Phe Pro Glu Ser Gly Arg
              20                  25                  30

 caa tgg gag aag cag agc tcc tcg tct cgc tta aag tca ggc att ttt      144
 Gln Trp Glu Lys Gln Ser Ser Ser Ser Arg Leu Lys Ser Gly Ile Phe
          35                  40                  45

 cct aag tca ttt atc cac atc aag gaa gtg aca gtt gag aaa aga aga      192
 Pro Lys Ser Phe Ile His Ile Lys Glu Val Thr Val Glu Lys Arg Arg
      50                  55                  60

 aat act gag aac atc att cct gca gaa att cct ctg gca caa gaa gtg      240
 Asn Thr Glu Asn Ile Ile Pro Ala Glu Ile Pro Leu Ala Gln Glu Val
  65                  70                  75                  80

 aca acg aca ctt tgg gaa tgg gga agc atc tgg aaa caa ctc tat gtg      288
 Thr Thr Thr Leu Trp Glu Trp Gly Ser Ile Trp Lys Gln Leu Tyr Val
                  85                  90                  95

 gcc agc aaa aag gag cgt ttt ctc cag gtg cag tcc atg atg tac gat      336
 Ala Ser Lys Lys Glu Arg Phe Leu Gln Val Gln Ser Met Met Tyr Asp
             100                 105                 110

 ctg atg gag tgg agg tcc cag ctt ctc tca gga acc tta ccc aag gat      384
 Leu Met Glu Trp Arg Ser Gln Leu Leu Ser Gly Thr Leu Pro Lys Asp
         115                 120                 125

 gag ctg aag gaa ctg aag cag aaa gtc acg tcc aaa att gac tat ggc      432
 Glu Leu Lys Glu Leu Lys Gln Lys Val Thr Ser Lys Ile Asp Tyr Gly
     130                 135                 140

 aac aaa agc ttg ttt tca ttt tta gat gca att ttg tca ctt tct gtt      480
 Asn Lys Ser Leu Phe Ser Phe Leu Asp Ala Ile Leu Ser Leu Ser Val
 145                 150                 155                 160

 tgg gag aag gtt gtg acc aat ggc tgt gct tgc gtg ccg ttg tta cca      528
 Trp Glu Lys Val Val Thr Asn Gly Cys Ala Cys Val Pro Leu Leu Pro
                 165                 170                 175

 ccc ctg ggg gac cta ggg aca tgc aga atc tgg tac tta gta gtc gca      576
 Pro Leu Gly Asp Leu Gly Thr Cys Arg Ile Trp Tyr Leu Val Val Ala
             180                 185                 190

 acc aag cag gag tat ggt tgg cct tct cag aat cca tca gcc cca cct      624
 Thr Lys Gln Glu Tyr Gly Trp Pro Ser Gln Asn Pro Ser Ala Pro Pro
         195                 200                 205

 cct cct acc ttc ttt gta tgg aca act gag gct ctt cat ctc aat atc      672
 Pro Pro Thr Phe Phe Val Trp Thr Thr Glu Ala Leu His Leu Asn Ile
     210                 215                 220

 aag tgc aaa agc agt ttc aag ttc aag ttt ttg ctt tac aga atc ctt      720
 Lys Cys Lys Ser Ser Phe Lys Phe Lys Phe Leu Leu Tyr Arg Ile Leu
 225                 230                 235                 240

 gag ctt gat ttg att gtc aga gat gaa gac gga aat atc ttg gac cct      768
 Glu Leu Asp Leu Ile Val Arg Asp Glu Asp Gly Asn Ile Leu Asp Pro
                 245                 250                 255

 gat aat acc agt gtc atc agc ttg ttc cat gca cat gag gaa gca act      816
 Asp Asn Thr Ser Val Ile Ser Leu Phe His Ala His Glu Glu Ala Thr
             260                 265                 270

 gat aaa atc aca gag cgt atc aaa gaa gaa atg tca aaa gac cag cca      864
 Asp Lys Ile Thr Glu Arg Ile Lys Glu Glu Met Ser Lys Asp Gln Pro
         275                 280                 285

 gat tat gca atg tat tcc cgg atc tcc tca tcc ccc acc cat agc ctc      912
 Asp Tyr Ala Met Tyr Ser Arg Ile Ser Ser Ser Pro Thr His Ser Leu
     290                 295                 300

 tat gtg ttt gtg aga aac ttt gtg tgc aga att ggg gaa gat gct gag      960
 Tyr Val Phe Val Arg Asn Phe Val Cys Arg Ile Gly Glu Asp Ala Glu
 305                 310                 315                 320

 ctc ttc atg tct ctc tac gac ccc aac aag caa acg gtc ata agt gag     1008
 Leu Phe Met Ser Leu Tyr Asp Pro Asn Lys Gln Thr Val Ile Ser Glu
                 325                 330                 335

 aac tac cta gtg cga tgg ggc agc cgg ggc ttc cct aag gag att gag     1056
 Asn Tyr Leu Val Arg Trp Gly Ser Arg Gly Phe Pro Lys Glu Ile Glu
             340                 345                 350

 atg ctc aac aat ctg aag gtg gtc ttc acg gtg agt gtg cac cct ctt     1104
 Met Leu Asn Asn Leu Lys Val Val Phe Thr Val Ser Val His Pro Leu
         355                 360                 365

 ctc gtt acc gtg ctc ccc aac cac aaa aat gtg acc ttg gaa atg agg     1152
 Leu Val Thr Val Leu Pro Asn His Lys Asn Val Thr Leu Glu Met Arg
     370                 375                 380

 ctg gat ctt gga aac aaa gac ctc aac agg gat aaa att tac ttg att     1200
 Leu Asp Leu Gly Asn Lys Asp Leu Asn Arg Asp Lys Ile Tyr Leu Ile
 385                 390                 395                 400

 tgt caa ata gtc cgg gtc ggc aag atg gat ctt aag gat act ggt gca     1248
 Cys Gln Ile Val Arg Val Gly Lys Met Asp Leu Lys Asp Thr Gly Ala
                 405                 410                 415

 aag aag tgc acg cag gga ctg agg agg ccc ttt ggg gtg gca gtt atg     1296
 Lys Lys Cys Thr Gln Gly Leu Arg Arg Pro Phe Gly Val Ala Val Met
             420                 425                 430

 gat ata aca gac atc atc aag ggg aaa gca gag agt gat gaa gaa aag     1344
 Asp Ile Thr Asp Ile Ile Lys Gly Lys Ala Glu Ser Asp Glu Glu Lys
         435                 440                 445

 cag cac ttc att cct ttt cac ccg gtt aca gct gag aat gac ttc cta     1392
 Gln His Phe Ile Pro Phe His Pro Val Thr Ala Glu Asn Asp Phe Leu
     450                 455                 460

 cac agc ctg ctg ggc aaa gtc ata gcc tcc aag ggg gac agt gga ggg     1440
 His Ser Leu Leu Gly Lys Val Ile Ala Ser Lys Gly Asp Ser Gly Gly
 465                 470                 475                 480

 caa ggc ctc tgg gtg acc atg aag atg ctg gtg ggt gac atc att cag     1488
 Gln Gly Leu Trp Val Thr Met Lys Met Leu Val Gly Asp Ile Ile Gln
                 485                 490                 495

 att cgc aag gac tat cca cac ctg gtg gac agg acc acc gtg gtg gcc     1536
 Ile Arg Lys Asp Tyr Pro His Leu Val Asp Arg Thr Thr Val Val Ala
             500                 505                 510

 agg aag ctg gga ttc cca gag atc atc atg cca ggg gat gtc agg aac     1584
 Arg Lys Leu Gly Phe Pro Glu Ile Ile Met Pro Gly Asp Val Arg Asn
         515                 520                 525

 gac atc tac att act ctc tta caa ggt gac ttt gac aag tac aac aag     1632
 Asp Ile Tyr Ile Thr Leu Leu Gln Gly Asp Phe Asp Lys Tyr Asn Lys
     530                 535                 540

 acc aca cag agg aat gtg gaa gtc atc atg tgt gtg tgc gcg gag gat     1680
 Thr Thr Gln Arg Asn Val Glu Val Ile Met Cys Val Cys Ala Glu Asp
 545                 550                 555                 560

 ggc aaa acg ctg cct aat gca att tgc gtg gga gca ggg gac aag ccc     1728
 Gly Lys Thr Leu Pro Asn Ala Ile Cys Val Gly Ala Gly Asp Lys Pro
                 565                 570                 575

 atg aat gag tat cgc tcc gtt gtg tac tat caa gtc aaa cag cca cgc     1776
 Met Asn Glu Tyr Arg Ser Val Val Tyr Tyr Gln Val Lys Gln Pro Arg
             580                 585                 590

 tgg atg gaa aca gtc aag ggg aga aga atg gaa gag ctg ggt ggc cca     1824
 Trp Met Glu Thr Val Lys Gly Arg Arg Met Glu Glu Leu Gly Gly Pro
         595                 600                 605

 tgt atc att ttc ttt cct gac ccc aca atg cta ttt cca gct aaa gat     1872
 Cys Ile Ile Phe Phe Pro Asp Pro Thr Met Leu Phe Pro Ala Lys Asp
     610                 615                 620

 aaa gga gaa aag aac ttt gcc atg tcc tat gtg aag ctg atg aaa gaa     1920
 Lys Gly Glu Lys Asn Phe Ala Met Ser Tyr Val Lys Leu Met Lys Glu
 625                 630                 635                 640

 gat ggg act act cta cac gat gga ttc cat gac tta gtt gtc ctc aag     1968
 Asp Gly Thr Thr Leu His Asp Gly Phe His Asp Leu Val Val Leu Lys
                 645                 650                 655

 gct ctg tgt ggc att ggg cat gga gcc ttg gct tgg ggc agt aac caa     2016
 Ala Leu Cys Gly Ile Gly His Gly Ala Leu Ala Trp Gly Ser Asn Gln
             660                 665                 670

 gtg ttg ttt cca ggg gga cag caa gaa gat gga gga tgc cag cgc ata     2064
 Val Leu Phe Pro Gly Gly Gln Gln Glu Asp Gly Gly Cys Gln Arg Ile
         675                 680                 685

 cct gac cct tcc ttc tta tcg aca cca tgt gga aaa caa ggg ggc cac     2112
 Pro Asp Pro Ser Phe Leu Ser Thr Pro Cys Gly Lys Gln Gly Gly His
     690                 695                 700

 gct gag cag gag ctc cag cag tgt tgg ggg gct ttc tgt cag ctc ccg     2160
 Ala Glu Gln Glu Leu Gln Gln Cys Trp Gly Ala Phe Cys Gln Leu Pro
 705                 710                 715                 720

 gga tgt gtt ctc cat ttc cac cct gtg ggc ttg ctg ggt ttg ctg aag     2208
 Gly Cys Val Leu His Phe His Pro Val Gly Leu Leu Gly Leu Leu Lys
                 725                 730                 735

 tgg cgt atg aag cct caa ctg cta cag gag aat tta gaa aag ttg aag     2256
 Trp Arg Met Lys Pro Gln Leu Leu Gln Glu Asn Leu Glu Lys Leu Lys
             740                 745                 750

 att gtg gat gga gag gaa gtg gtg aag ttt ctc cag gat act ctg gat     2304
 Ile Val Asp Gly Glu Glu Val Val Lys Phe Leu Gln Asp Thr Leu Asp
         755                 760                 765

 gcc ctc ttc aac atc atg atg gag cat tct caa agt gat gaa tat gac     2352
 Ala Leu Phe Asn Ile Met Met Glu His Ser Gln Ser Asp Glu Tyr Asp
     770                 775                 780

 atc ctc gtc ttt gat gcc ttg att tac ata ata gga ctc att gca gac     2400
 Ile Leu Val Phe Asp Ala Leu Ile Tyr Ile Ile Gly Leu Ile Ala Asp
 785                 790                 795                 800

 cgg aaa ttt cag cat ttc aac acc gtt ctg gag gct tac atc caa cag     2448
 Arg Lys Phe Gln His Phe Asn Thr Val Leu Glu Ala Tyr Ile Gln Gln
                 805                 810                 815

 cat ttc agt gcg acc ttg gct tac aag aaa ttg atg aca gtg ctg aag     2496
 His Phe Ser Ala Thr Leu Ala Tyr Lys Lys Leu Met Thr Val Leu Lys
             820                 825                 830

 act tac ttg gat acc tcc agc aga ggg gag caa tgt gag cca atc cta     2544
 Thr Tyr Leu Asp Thr Ser Ser Arg Gly Glu Gln Cys Glu Pro Ile Leu
         835                 840                 845

 aga acg ctg aag gct ttg gaa tat gtg ttc aag ttc att gtt cgg tcg     2592
 Arg Thr Leu Lys Ala Leu Glu Tyr Val Phe Lys Phe Ile Val Arg Ser
     850                 855                 860

 agg aca tta ttt tca caa act aaa cat ggc ata cta tat agt aat cat     2640
 Arg Thr Leu Phe Ser Gln Thr Lys His Gly Ile Leu Tyr Ser Asn His
 865                 870                 875                 880

 gct ttt gtt gac tgt ccc ttc ctt gct gga atg tca gat cca tca gta     2688
 Ala Phe Val Asp Cys Pro Phe Leu Ala Gly Met Ser Asp Pro Ser Val
                 885                 890                 895

 cag gaa cct ttg act gtt ttg tac tct gtg gga atg aat aaa gaa aag     2736
 Gln Glu Pro Leu Thr Val Leu Tyr Ser Val Gly Met Asn Lys Glu Lys
             900                 905                 910

 ttg aca cag ggc agg cca ggt gag ctc aca ctc ctt ggg aac aag tca     2784
 Leu Thr Gln Gly Arg Pro Gly Glu Leu Thr Leu Leu Gly Asn Lys Ser
         915                 920                 925

 ctg gtt ggg gag aga aaa att gca ctc tgt gtc ctg atg gga gct tca     2832
 Leu Val Gly Glu Arg Lys Ile Ala Leu Cys Val Leu Met Gly Ala Ser
     930                 935                 940

 gca cct gga agc ttc atc ctg ctc cct acc ccc gag agc cga gaa agc     2880
 Ala Pro Gly Ser Phe Ile Leu Leu Pro Thr Pro Glu Ser Arg Glu Ser
 945                 950                 955                 960

 ctg ccc tgg tgt gca cag ttc cac tgg cct gca ctg gag ctg cca cca     2928
 Leu Pro Trp Cys Ala Gln Phe His Trp Pro Ala Leu Glu Leu Pro Pro
                 965                 970                 975

 cat taa                                                             2934
 His 






      <210> 652
      <211> 1084
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (920)..(1084)

      <400> 652
 tggcgtctcc gcttctcact tcagaggcag agctgtcatc gtgggcactg ggaagtagcc     60

 tgcagtgtca gcacagaccg gcgctcacca acgacacggc acggaggctt tctagggagc    120

 agtcccccca ggacagcaat acgttcaggc gacagcgaca cagggcagca acagcggttc    180

 cctcctggca ggcagccaga cgcacacacg cacgcagacc acaccatcca gaaagttcac    240

 ctgcgacctg agacgcagct ctttgaggga gatcagaaga tcagatggag catcccagtt    300

 gtgataacca cacgtcccca aacatcgccc agtgccccct ggggggcagc atcacccaca    360

 tttaaaaaca gttccagggt agcagcctgc aaagaaggcg tctgttgcga gaccacatcc    420

 tcaccacccg gtgaacggca ctgggagcag actcaagagg ctcgagaggt cccaggaggg    480

 cgggaagaga gttcccccag ctacagcctg agcatggtcg ccagaaagca ggatctggtg    540

 acctggaaca gactcctgta tgggcctttt tcccctggtg ccagcaggga acagggcagg    600

 atggaaaaaa cacccagtag ccagtggccc actgatgtca ccaagctgca gggctgccca    660

 gcattgatta aacacagctg ttttattggc acacggccac acccacttgt tgacatattg    720

 cttgtggtgg ctttcccgct acaatggcag gcagagactg tccagcctgc aaaggctaaa    780

 acatttgcca tctggatctc tgcagaaaag tttgctaccc caggcctcgc acatacaaac    840

 gccaccatgg agcaggactc agccatgaaa aggaacaagg ctctgatgcc ggccacagtg    900

 tggatggacc ttgaggaca tca cac tct atg aaa gga gcc aga gac aga ggg     952
                      Met Ser Ser Arg Ser Ile His Thr Val Ala Gly
                        1               5                  10

 cca cgc aaa att ctc agg agg cag cgc ttg gtg gct ctt ctg cag atg     1000
 Ile Arg Ala Leu Phe Leu Phe Met Ala Glu Ser Cys Ser Met Val Ala
              15                  20                  25

 cca gga tgg tga cgg tga cag cag gcc acg ctc ttg tgt tta gaa tag     1048
 Phe Val Cys Ala Arg Pro Gly Val Ala Asn Phe Ser Ala Glu Ile Gln
          30                  35                  40

 gag gtc ccc aag gac aca gag tca cag acg ggt cag                     1084
 Met Ala Asn Val Leu Ala Phe Ala Gly Trp Thr Val Ser Ala Cys His 
      45                  50                  55





      <210> 653
      <211> 330
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (1)..(330)

      <400> 653
  atg gat gtc acc cgc tta ctc ctg gcc acc ctg ctg gtc ttc ctc tgc      48
  Met Asp Val Thr Arg Leu Leu Leu Ala Thr Leu Leu Val Phe Leu Cys
    1               5                  10                  15

 ttc ttc act gcc aac agc cac ctg cca cct gag gag aag ctc cga gat       96
 Phe Phe Thr Ala Asn Ser His Leu Pro Pro Glu Glu Lys Leu Arg Asp
              20                  25                  30

 gac agg agc ctg aga agc aac tcc tct gtg aac cta ctg gat gtc cct      144
 Asp Arg Ser Leu Arg Ser Asn Ser Ser Val Asn Leu Leu Asp Val Pro
          35                  40                  45

 tct gtc tct att gtg gcg ctg aac aag aaa tcc aaa cag atc ggc aga      192
 Ser Val Ser Ile Val Ala Leu Asn Lys Lys Ser Lys Gln Ile Gly Arg
      50                  55                  60

 aaa gca gca gaa aag aaa aga tct tct aag gaa aag aag cag caa gct      240
 Lys Ala Ala Glu Lys Lys Arg Ser Ser Lys Glu Lys Lys Gln Gln Ala
  65                  70                  75                  80

 gtg gca gca gtg tcc aag aca gct cct gct ggg ttc ctg cag cag gaa      288
 Val Ala Ala Val Ser Lys Thr Ala Pro Ala Gly Phe Leu Gln Gln Glu
                  85                  90                  95

 ctc acc tgc tgc gtt cgg tgc aca gcg ggg cag cga agt taa              330
 Leu Thr Cys Cys Val Arg Cys Thr Ala Gly Gln Arg Ser 
             100                 105





      <210> 654
      <211> 1752
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (1)..(1752)

      <400> 654
  atg cag cgt ctg ttg act cca gtg aag cgc att ctg caa ctg aca aga      48
  Met Gln Arg Leu Leu Thr Pro Val Lys Arg Ile Leu Gln Leu Thr Arg
    1               5                  10                  15

 gcg gtg cag gaa acc tcc ctc aca cct gct cgc ctg ctc cca gta gcc       96
 Ala Val Gln Glu Thr Ser Leu Thr Pro Ala Arg Leu Leu Pro Val Ala
              20                  25                  30

 cac caa agg ttt tct aca gcc tct gct gtc ccc ctg gcc aaa aca gat      144
 His Gln Arg Phe Ser Thr Ala Ser Ala Val Pro Leu Ala Lys Thr Asp
          35                  40                  45

 act tgg cca aag gac gtg ggc atc ctg gcc ctg gag gtc tac ttc cca      192
 Thr Trp Pro Lys Asp Val Gly Ile Leu Ala Leu Glu Val Tyr Phe Pro
      50                  55                  60

 gcc caa tat gtg gac caa act gac ctg gag aag tat aac aat gtg gaa      240
 Ala Gln Tyr Val Asp Gln Thr Asp Leu Glu Lys Tyr Asn Asn Val Glu
  65                  70                  75                  80

 gca gga aag tat aca gtg ggc ttg ggc cag acc cgt atg ggc ttc tgc      288
 Ala Gly Lys Tyr Thr Val Gly Leu Gly Gln Thr Arg Met Gly Phe Cys
                  85                  90                  95

 tca gtc caa gag gac atc aac tcc ctg tgc ctg acg gtg gtg caa cgg      336
 Ser Val Gln Glu Asp Ile Asn Ser Leu Cys Leu Thr Val Val Gln Arg
             100                 105                 110

 ctg atg gag cgc ata cag ctc cca tgg gac tct gtg ggc agg ctg gaa      384
 Leu Met Glu Arg Ile Gln Leu Pro Trp Asp Ser Val Gly Arg Leu Glu
         115                 120                 125

 gta ggc act gag acc atc att gac aag tcc aaa gct gtc aaa aca gtg      432
 Val Gly Thr Glu Thr Ile Ile Asp Lys Ser Lys Ala Val Lys Thr Val
     130                 135                 140

 ctc atg gaa ctc ttc cag gat tca ggc aat act gat att gag ggc ata      480
 Leu Met Glu Leu Phe Gln Asp Ser Gly Asn Thr Asp Ile Glu Gly Ile
 145                 150                 155                 160

 gat acc acc aat gcc tgc tac ggt ggt act gcc tcc ctc ttc aat gct      528
 Asp Thr Thr Asn Ala Cys Tyr Gly Gly Thr Ala Ser Leu Phe Asn Ala
                 165                 170                 175

 gcc aac tgg atg gag tcc agt tcc tgg gat ggt atg tac ggc cac gaa      576
 Ala Asn Trp Met Glu Ser Ser Ser Trp Asp Gly Met Tyr Gly His Glu
             180                 185                 190

 cct tat gta aga aag gtg ctg gaa ttg gag gct gaa tat tac cag ttt      624
 Pro Tyr Val Arg Lys Val Leu Glu Leu Glu Ala Glu Tyr Tyr Gln Phe
         195                 200                 205

 tgc ttt tca gtt ccc cag atg tat gca agt tta gat gtt cgg gaa aaa      672
 Cys Phe Ser Val Pro Gln Met Tyr Ala Ser Leu Asp Val Arg Glu Lys
     210                 215                 220

 aac acc ttc ata gaa aca ggc cca gaa aac cac aag ata gac tgt cgt      720
 Asn Thr Phe Ile Glu Thr Gly Pro Glu Asn His Lys Ile Asp Cys Arg
 225                 230                 235                 240

 tat gcc atg gtg gtc tgt gga gac att gcc gtc tat ccc agt ggt aat      768
 Tyr Ala Met Val Val Cys Gly Asp Ile Ala Val Tyr Pro Ser Gly Asn
                 245                 250                 255

 gct cgt ccc aca ggt ggg gcc gga gct gtg gct atg ctg att ggg ccc      816
 Ala Arg Pro Thr Gly Gly Ala Gly Ala Val Ala Met Leu Ile Gly Pro
             260                 265                 270

 aag gcc cct ctg gcc ctg gag cga ggg ctg gtc tat gga gca gag gga      864
 Lys Ala Pro Leu Ala Leu Glu Arg Gly Leu Val Tyr Gly Ala Glu Gly
         275                 280                 285

 gga gag gag aaa tgg gag agg gga atc cgc gag gct tcc tct ctt gca      912
 Gly Glu Glu Lys Trp Glu Arg Gly Ile Arg Glu Ala Ser Ser Leu Ala
     290                 295                 300

 tca tca ggc att ggg ata acg atg cat gga atg agt ggt gca gat gat      960
 Ser Ser Gly Ile Gly Ile Thr Met His Gly Met Ser Gly Ala Asp Asp
 305                 310                 315                 320

 ggg ctg agg gga acc cat atg gag aat gtg tat gac ttc tac aaa cca     1008
 Gly Leu Arg Gly Thr His Met Glu Asn Val Tyr Asp Phe Tyr Lys Pro
                 325                 330                 335

 aat ttg gcc tcg gag tac cca ata gtg gat ggg aag ctt tcc atc cag     1056
 Asn Leu Ala Ser Glu Tyr Pro Ile Val Asp Gly Lys Leu Ser Ile Gln
             340                 345                 350

 tgc tac ttg cgg gcc ttg gat cga tgt tac aca tca tac cgt aaa aaa     1104
 Cys Tyr Leu Arg Ala Leu Asp Arg Cys Tyr Thr Ser Tyr Arg Lys Lys
         355                 360                 365

 atc cag aat cag tgg aag caa gct ggc agc gat cga ccc ttc acc ctt     1152
 Ile Gln Asn Gln Trp Lys Gln Ala Gly Ser Asp Arg Pro Phe Thr Leu
     370                 375                 380

 gac gat tta cag tac atg atc ttt cat aca ccc ttt tgc aag atg gtc     1200
 Asp Asp Leu Gln Tyr Met Ile Phe His Thr Pro Phe Cys Lys Met Val
 385                 390                 395                 400

 cag aag tct ctg gct cgc ctg atg ttc aat gac ttc ctg tca gcc agc     1248
 Gln Lys Ser Leu Ala Arg Leu Met Phe Asn Asp Phe Leu Ser Ala Ser
                 405                 410                 415

 agt gac aca caa acc agc tta tat aag ggg ctg gag gct ttc ggg ggg     1296
 Ser Asp Thr Gln Thr Ser Leu Tyr Lys Gly Leu Glu Ala Phe Gly Gly
             420                 425                 430

 cta aag ctg gaa gac acc tac acc aac aag gac ctg gat aaa gca ctt     1344
 Leu Lys Leu Glu Asp Thr Tyr Thr Asn Lys Asp Leu Asp Lys Ala Leu
         435                 440                 445

 cta aag gcc tct cag gac atg ttc gac aag aaa acc aag gct tcc ctt     1392
 Leu Lys Ala Ser Gln Asp Met Phe Asp Lys Lys Thr Lys Ala Ser Leu
     450                 455                 460

 tac ctc tcc act cac aat ggg aac atg tac acc tca tcc ctg tac ggg     1440
 Tyr Leu Ser Thr His Asn Gly Asn Met Tyr Thr Ser Ser Leu Tyr Gly
 465                 470                 475                 480

 tgc ctg gcc tcg ctt ctg tcc cac cac tct gcc caa gaa ctg gct ggc     1488
 Cys Leu Ala Ser Leu Leu Ser His His Ser Ala Gln Glu Leu Ala Gly
                 485                 490                 495

 tcc agg att ggt gcc ttc tct tat ggc tct ggt tta gca gca agt ttc     1536
 Ser Arg Ile Gly Ala Phe Ser Tyr Gly Ser Gly Leu Ala Ala Ser Phe
             500                 505                 510

 ttt tca ttt cga gta tcc cag gat gct gct cca ggc tct ccc ctg gac     1584
 Phe Ser Phe Arg Val Ser Gln Asp Ala Ala Pro Gly Ser Pro Leu Asp
         515                 520                 525

 aag ttg gtg tcc agc aca tca gac ctg cca aaa cgc cta gcc tcc cga     1632
 Lys Leu Val Ser Ser Thr Ser Asp Leu Pro Lys Arg Leu Ala Ser Arg
     530                 535                 540

 aag tgt gtg tct cct gag gag ttc aca gaa ata atg aac caa aga gag     1680
 Lys Cys Val Ser Pro Glu Glu Phe Thr Glu Ile Met Asn Gln Arg Glu
 545                 550                 555                 560

 caa ttc tac cat aag gca tgg tct caa aag gag aca gaa tat acg gaa     1728
 Gln Phe Tyr His Lys Ala Trp Ser Gln Lys Glu Thr Glu Tyr Thr Glu
                 565                 570                 575

 ttg gaa atg ttc cag aaa acc tag                                     1752
 Leu Glu Met Phe Gln Lys Thr 
             580





      <210> 655
      <211> 306
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (1)..(306)

      <400> 655
  atg gcc ttg ctg caa acc ttg gga cct tca act gtg gcc ctg aga agc      48
  Met Ala Leu Leu Gln Thr Leu Gly Pro Ser Thr Val Ala Leu Arg Ser
    1               5                  10                  15

 cca cag tcc atc aga cag aag tta ttg gat cag aac ttt agg cgg tgg       96
 Pro Gln Ser Ile Arg Gln Lys Leu Leu Asp Gln Asn Phe Arg Arg Trp
              20                  25                  30

 ttt cct gag tct gcc gtg aag gtt ctc gca tca ggg tgt ctg cag aac      144
 Phe Pro Glu Ser Ala Val Lys Val Leu Ala Ser Gly Cys Leu Gln Asn
          35                  40                  45

 atg ctg ctg aag tcg ctg cag atg gac cca gtg ttc tgg gaa agc caa      192
 Met Leu Leu Lys Ser Leu Gln Met Asp Pro Val Phe Trp Glu Ser Gln
      50                  55                  60

 ggc gga gcc cag ggg ctg aag cag gtc ctc cag acc ctg gag cag cga      240
 Gly Gly Ala Gln Gly Leu Lys Gln Val Leu Gln Thr Leu Glu Gln Arg
  65                  70                  75                  80

 gga cag gtg ctg ctg gga cac atc caa aag cac aac ctc aca ctc ttc      288
 Gly Gln Val Leu Leu Gly His Ile Gln Lys His Asn Leu Thr Leu Phe
                  85                  90                  95

 agg gac gag gac cca taa                                              306
 Arg Asp Glu Asp Pro 
             100





      <210> 656
      <211> 762
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (1)..(762)

      <400> 656
  atg ccc ggc ttc aag tca ctt ttc ttc tca gca gtc tgc agc tgg gtt      48
  Met Pro Gly Phe Lys Ser Leu Phe Phe Ser Ala Val Cys Ser Trp Val
    1               5                  10                  15

 cac tct gcc cat ccc cag gta gca ggg ttc ctg cag gcc tgg cat gta       96
 His Ser Ala His Pro Gln Val Ala Gly Phe Leu Gln Ala Trp His Val
              20                  25                  30

 ggg aac aaa gtg gcc act cga aat ctg agt gac ccc cca ccc cag caa      144
 Gly Asn Lys Val Ala Thr Arg Asn Leu Ser Asp Pro Pro Pro Gln Gln
          35                  40                  45

 gga aac aca gca agt ggt cac tat cat ttc act gtg gtc aga gat aac      192
 Gly Asn Thr Ala Ser Gly His Tyr His Phe Thr Val Val Arg Asp Asn
      50                  55                  60

 gtg aag ctg gga aca ata gtg aac atg ttg gat gat aga tac agc ttc      240
 Val Lys Leu Gly Thr Ile Val Asn Met Leu Asp Asp Arg Tyr Ser Phe
  65                  70                  75                  80

 ctg aaa gat ctc agc aga caa gaa gaa tgg agc aaa tgc agc aat tca      288
 Leu Lys Asp Leu Ser Arg Gln Glu Glu Trp Ser Lys Cys Ser Asn Ser
                  85                  90                  95

 gag aac agc atc aag tcc cac atg agc agg aaa cgc ggc cct gag gtg      336
 Glu Asn Ser Ile Lys Ser His Met Ser Arg Lys Arg Gly Pro Glu Val
             100                 105                 110

 tca cgt cct gcg tgg caa aga aag tgg ttt ctt gag atg gaa tcc act      384
 Ser Arg Pro Ala Trp Gln Arg Lys Trp Phe Leu Glu Met Glu Ser Thr
         115                 120                 125

 cct ggt gaa gat gct gtg aac att att gaa atg aca aca aag gat tta      432
 Pro Gly Glu Asp Ala Val Asn Ile Ile Glu Met Thr Thr Lys Asp Leu
     130                 135                 140

 gac tat gac tta aac tta gtt gat aaa gct gcc gca ggg ttt aag agg      480
 Asp Tyr Asp Leu Asn Leu Val Asp Lys Ala Ala Ala Gly Phe Lys Arg
 145                 150                 155                 160

 att gac tcc aat ttt gaa aga agt tct act gtg gga gga gat aca aag      528
 Ile Asp Ser Asn Phe Glu Arg Ser Ser Thr Val Gly Gly Asp Thr Lys
                 165                 170                 175

 atg gcc ata gaa ggc ttt tta gaa gaa gga ctt gaa ctt ggt ttg aaa      576
 Met Ala Ile Glu Gly Phe Leu Glu Glu Gly Leu Glu Leu Gly Leu Lys
             180                 185                 190

 gga gga gaa aaa gat tac ctg gga aca aga gtg ttc ctg atg ttc aag      624
 Gly Gly Glu Lys Asp Tyr Leu Gly Thr Arg Val Phe Leu Met Phe Lys
         195                 200                 205

 tgg cca gac tgg gac aca tct gct tcc act gca gta agt gaa atg gag      672
 Trp Pro Asp Trp Asp Thr Ser Ala Ser Thr Ala Val Ser Glu Met Glu
     210                 215                 220

 ggc tac aaa aag cag gac aat gtc att tgt cag aaa cca cgc tgc acc      720
 Gly Tyr Lys Lys Gln Asp Asn Val Ile Cys Gln Lys Pro Arg Cys Thr
 225                 230                 235                 240

 aac ccc ttt gga cct aaa tta atg tat tcc atc aag cca taa              762
 Asn Pro Phe Gly Pro Lys Leu Met Tyr Ser Ile Lys Pro 
                 245                 250





      <210> 657
      <211> 564
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (1)..(564)

      <400> 657
  atg gcg ctg cga gtg gtg cgg agc gtg cgg gcc ctg ctc tgc acc ctg      48
  Met Ala Leu Arg Val Val Arg Ser Val Arg Ala Leu Leu Cys Thr Leu
    1               5                  10                  15

 cgc gcg gtc ccg tca ccc gcc gcg ccc tgc ccg ccg agg ccc tgg cag       96
 Arg Ala Val Pro Ser Pro Ala Ala Pro Cys Pro Pro Arg Pro Trp Gln
              20                  25                  30

 ctg ggg gtg ggc gcc gtc cgt acg ctg cgc act gga ccc gct ctg ctc      144
 Leu Gly Val Gly Ala Val Arg Thr Leu Arg Thr Gly Pro Ala Leu Leu
          35                  40                  45

 tcg gga ttc cct gaa tcg ttt gac cgt atc ttt aga gaa gtg ctc atg      192
 Ser Gly Phe Pro Glu Ser Phe Asp Arg Ile Phe Arg Glu Val Leu Met
      50                  55                  60

 cgt aaa ttc aca gag aaa cac gaa tgg gta aca aca gaa aat ggc att      240
 Arg Lys Phe Thr Glu Lys His Glu Trp Val Thr Thr Glu Asn Gly Ile
  65                  70                  75                  80

 gga aca gtg gga atc agc aat ttt gca cag gaa gcg ttg gga gat gtt      288
 Gly Thr Val Gly Ile Ser Asn Phe Ala Gln Glu Ala Leu Gly Asp Val
                  85                  90                  95

 gtt tat tgt agt ctc cct gaa gtt ggg aca aaa ttg aac aaa caa gat      336
 Val Tyr Cys Ser Leu Pro Glu Val Gly Thr Lys Leu Asn Lys Gln Asp
             100                 105                 110

 gag ttt ggt gct ttg gaa agt gtg aaa gct gct agt gaa ctc tat tct      384
 Glu Phe Gly Ala Leu Glu Ser Val Lys Ala Ala Ser Glu Leu Tyr Ser
         115                 120                 125

 cct tta tca gga gaa gta act gaa att aat gaa gct ctt gca gaa aat      432
 Pro Leu Ser Gly Glu Val Thr Glu Ile Asn Glu Ala Leu Ala Glu Asn
     130                 135                 140

 cca gga ctt gta aac aaa tct tgt tat gaa gat ggt tgg ctg atc aag      480
 Pro Gly Leu Val Asn Lys Ser Cys Tyr Glu Asp Gly Trp Leu Ile Lys
 145                 150                 155                 160

 atg aca ctg agt aac cct tca gaa cta gat gaa ctt atg agt gaa gaa      528
 Met Thr Leu Ser Asn Pro Ser Glu Leu Asp Glu Leu Met Ser Glu Glu
                 165                 170                 175

 gca tat gag aaa tac ata aaa tct att gag gag tga                      564
 Ala Tyr Glu Lys Tyr Ile Lys Ser Ile Glu Glu 
             180                 185





      <210> 658
      <211> 342
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (1)..(342)

      <400> 658
  atg gac caa act cta aat gct gtg gga cat atg tgg gca ccc gtg gtt      48
  Met Asp Gln Thr Leu Asn Ala Val Gly His Met Trp Ala Pro Val Val
    1               5                  10                  15

 gcc atc tat ttc att ctc tat cat ctt ttt gcc act ctg aat gag ggc       96
 Ala Ile Tyr Phe Ile Leu Tyr His Leu Phe Ala Thr Leu Asn Glu Gly
              20                  25                  30

 ttg tca ccc act ccc atg act ttc cat acc atg tgt tgg caa gtg tct      144
 Leu Ser Pro Thr Pro Met Thr Phe His Thr Met Cys Trp Gln Val Ser
          35                  40                  45

 gac acc cag gtc gac ctg ctc ttt cag tcc aaa tcc aca ttg cac tgg      192
 Asp Thr Gln Val Asp Leu Leu Phe Gln Ser Lys Ser Thr Leu His Trp
      50                  55                  60

 atc ctc ctg agt ttg ttt gtt gct gtt att ttg gac aac tta gaa ctt      240
 Ile Leu Leu Ser Leu Phe Val Ala Val Ile Leu Asp Asn Leu Glu Leu
  65                  70                  75                  80

 gat gaa gac cta aag aag ctt aaa caa att gag ggc ggt agc aag gtg      288
 Asp Glu Asp Leu Lys Lys Leu Lys Gln Ile Glu Gly Gly Ser Lys Val
                  85                  90                  95

 gca ggg ata ctg ctg gaa gat gcc att cgg ctg agc act ggt tgc atc      336
 Ala Gly Ile Leu Leu Glu Asp Ala Ile Arg Leu Ser Thr Gly Cys Ile
             100                 105                 110

 tcc tga                                                              342
 Ser 






      <210> 659
      <211> 1320
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (1)..(1320)

      <400> 659
  atg aac cat ttt ggt acc tgg ttg gtg gga ggc agg gtg acc cca ttg      48
  Met Asn His Phe Gly Thr Trp Leu Val Gly Gly Arg Val Thr Pro Leu
    1               5                  10                  15

 ctg cca ctg aaa gcc cgc aac aat gaa aat ctc aac aaa att gga tcg       96
 Leu Pro Leu Lys Ala Arg Asn Asn Glu Asn Leu Asn Lys Ile Gly Ser
              20                  25                  30

 ggg gta tat gtg cag gat tgt tac ata ggt ata ttg tgt gat gat gct      144
 Gly Val Tyr Val Gln Asp Cys Tyr Ile Gly Ile Leu Cys Asp Asp Ala
          35                  40                  45

 gag atg gtg agt ttt cag gca tca ctg gaa gat gaa aac gga gac atg      192
 Glu Met Val Ser Phe Gln Ala Ser Leu Glu Asp Glu Asn Gly Asp Met
      50                  55                  60

 ttt tat tct caa gcc cac tat agg gcc aat gaa ttc ggt gag gtg gac      240
 Phe Tyr Ser Gln Ala His Tyr Arg Ala Asn Glu Phe Gly Glu Val Asp
  65                  70                  75                  80

 ctg aat cat gct tct tca ctt gga ggg gat tat atg gga gtc cac ccc      288
 Leu Asn His Ala Ser Ser Leu Gly Gly Asp Tyr Met Gly Val His Pro
                  85                  90                  95

 atg ggt ctc ttc tgg tct ctg aaa cct gaa aag cta tta aca aga ctg      336
 Met Gly Leu Phe Trp Ser Leu Lys Pro Glu Lys Leu Leu Thr Arg Leu
             100                 105                 110

 ttg aaa aga gat gtg atg aat agg cct ttc cag gtc caa gta aaa ctt      384
 Leu Lys Arg Asp Val Met Asn Arg Pro Phe Gln Val Gln Val Lys Leu
         115                 120                 125

 tat gac tta gag tta ata gtg aac aat aaa gtt gcc agt gct cca aag      432
 Tyr Asp Leu Glu Leu Ile Val Asn Asn Lys Val Ala Ser Ala Pro Lys
     130                 135                 140

 gcc agc ctg act ttg gag agg tgg tat gtg gca cct ggt gtc aca cga      480
 Ala Ser Leu Thr Leu Glu Arg Trp Tyr Val Ala Pro Gly Val Thr Arg
 145                 150                 155                 160

 att aag gtt cga gaa ggc cgc ctt cga gga gct ctc ttt ctc cct cca      528
 Ile Lys Val Arg Glu Gly Arg Leu Arg Gly Ala Leu Phe Leu Pro Pro
                 165                 170                 175

 gga gag ggt ctc ttc cca ggg gta att gat ttg ttt ggt ggt ttg ggt      576
 Gly Glu Gly Leu Phe Pro Gly Val Ile Asp Leu Phe Gly Gly Leu Gly
             180                 185                 190

 ggg ctg ctt gaa ttt cgg gcc agc ctc cta gcc agt cgt ggc ttc gcc      624
 Gly Leu Leu Glu Phe Arg Ala Ser Leu Leu Ala Ser Arg Gly Phe Ala
         195                 200                 205

 tcc ttg gcc ttg gct tac cat aac tat gaa gac ctg ccc cgc aaa cca      672
 Ser Leu Ala Leu Ala Tyr His Asn Tyr Glu Asp Leu Pro Arg Lys Pro
     210                 215                 220

 gaa gta aca gat ttg gaa tat ttt gag gag gct gcc aac ttt ctc ctg      720
 Glu Val Thr Asp Leu Glu Tyr Phe Glu Glu Ala Ala Asn Phe Leu Leu
 225                 230                 235                 240

 aga cat cca aag gtc ttt ggc tca ggc gtt ggg gta gtc tct gta tgt      768
 Arg His Pro Lys Val Phe Gly Ser Gly Val Gly Val Val Ser Val Cys
                 245                 250                 255

 caa gga gta cag att gga cta tct atg gct att tac cta aag caa gtc      816
 Gln Gly Val Gln Ile Gly Leu Ser Met Ala Ile Tyr Leu Lys Gln Val
             260                 265                 270

 aca gcc acg gta ctt att aat ggg acc aac ttt cct ttt ggc att cca      864
 Thr Ala Thr Val Leu Ile Asn Gly Thr Asn Phe Pro Phe Gly Ile Pro
         275                 280                 285

 cag gta tat cat ggt cag atc cat cag ccc ctt ccc cat tct gca caa      912
 Gln Val Tyr His Gly Gln Ile His Gln Pro Leu Pro His Ser Ala Gln
     290                 295                 300

 tta ata tcc acc aat gcc ttg ggg tta cta gag ctc tat cgc act ttt      960
 Leu Ile Ser Thr Asn Ala Leu Gly Leu Leu Glu Leu Tyr Arg Thr Phe
 305                 310                 315                 320

 gag aca act caa gtt ggg gcc agt caa tat ttg ttt cct att gaa gag     1008
 Glu Thr Thr Gln Val Gly Ala Ser Gln Tyr Leu Phe Pro Ile Glu Glu
                 325                 330                 335

 gcc cag ggg caa ttc ctc ttc att gta gga gaa ggt gat aag act atc     1056
 Ala Gln Gly Gln Phe Leu Phe Ile Val Gly Glu Gly Asp Lys Thr Ile
             340                 345                 350

 aac agc aaa gca cac gct gaa caa gcc ata gga cag ctg aag aga cat     1104
 Asn Ser Lys Ala His Ala Glu Gln Ala Ile Gly Gln Leu Lys Arg His
         355                 360                 365

 ggg aag aac aac tgg acc ctg cta tct tac cct ggg gca ggc cac ctg     1152
 Gly Lys Asn Asn Trp Thr Leu Leu Ser Tyr Pro Gly Ala Gly His Leu
     370                 375                 380

 ata gaa cct ccc tat tct cct ctg tgc tgt gcc tca acg acc cac gat     1200
 Ile Glu Pro Pro Tyr Ser Pro Leu Cys Cys Ala Ser Thr Thr His Asp
 385                 390                 395                 400

 ttg agg tta cac tgg gga gga gag gtg atc cca cac gca gct gca cag     1248
 Leu Arg Leu His Trp Gly Gly Glu Val Ile Pro His Ala Ala Ala Gln
                 405                 410                 415

 gaa cat gct tgg aag gag atc cag aga ttt ctc agg aag cac ctc att     1296
 Glu His Ala Trp Lys Glu Ile Gln Arg Phe Leu Arg Lys His Leu Ile
             420                 425                 430

 cca gat gtg acc agt caa ctc taa                                     1320
 Pro Asp Val Thr Ser Gln Leu 
         435





      <210> 660
      <211> 485
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (96)..(485)

      <400> 660
 gcacctacaa atctgtccct tttcttattc tggaaattgg cagtcatcag ataggagctc     60

 tccccctggc tccctgcccc ttaaccatcc tcatc   atg atc ctt gcc gtc ttt     113
                                          Met Ile Leu Ala Val Phe
                                            1               5

 cct gcc cgc cag cct tgg tgc agt gct ttc ttg ggc ttc agg gcc atc      161
 Pro Ala Arg Gln Pro Trp Cys Ser Ala Phe Leu Gly Phe Arg Ala Ile
              10                  15                  20

 ctt ctc ttg ggc ttc tct tct tcc tca gct cct cag cac caa gaa atg      209
 Leu Leu Leu Gly Phe Ser Ser Ser Ser Ala Pro Gln His Gln Glu Met
          25                  30                  35

 aac aca gaa gcg gag caa cag ctt ctc cat cac gcc aga aat ggc aat      257
 Asn Thr Glu Ala Glu Gln Gln Leu Leu His His Ala Arg Asn Gly Asn
      40                  45                  50

 gct gaa gaa gta aga caa cta tta gag acc atg gcg agg aat gaa gtg      305
 Ala Glu Glu Val Arg Gln Leu Leu Glu Thr Met Ala Arg Asn Glu Val
  55                  60                  65                  70

 att gct gac att aat tgc aaa gaa tcc tat ttg gaa ata cta gat gtg      353
 Ile Ala Asp Ile Asn Cys Lys Glu Ser Tyr Leu Glu Ile Leu Asp Val
                  75                  80                  85

 agg aca cca ggt cac aag ctg tca gag gaa gtg aga gga gac agt gtg      401
 Arg Thr Pro Gly His Lys Leu Ser Glu Glu Val Arg Gly Asp Ser Val
              90                  95                 100

 gtt tgg atg ggg gca gac gca gtg gca atg gag aaa act aga tgt aat      449
 Val Trp Met Gly Ala Asp Ala Val Ala Met Glu Lys Thr Arg Cys Asn
         105                 110                 115

 gaa tat tta gga gtt gga gtc agt cga gct aat tga                      485
 Glu Tyr Leu Gly Val Gly Val Ser Arg Ala Asn 
     120                 125





      <210> 661
      <211> 2106
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (1)..(2106)

      <400> 661
  atg gcg gct ctg gcg aca agg gcc tgt tct cgt cat gtg ggt ttt ctt      48
  Met Ala Ala Leu Ala Thr Arg Ala Cys Ser Arg His Val Gly Phe Leu
    1               5                  10                  15

 gga cag ctt ttt ggg ccg atg atg gaa tat gcc gct gag cca cat aga       96
 Gly Gln Leu Phe Gly Pro Met Met Glu Tyr Ala Ala Glu Pro His Arg
              20                  25                  30

 aac gac aaa cca aga cac cag caa ggc aag tac tca acg ttt gag gat      144
 Asn Asp Lys Pro Arg His Gln Gln Gly Lys Tyr Ser Thr Phe Glu Asp
          35                  40                  45

 tca gga gca ttt ttc aag aaa tgt gtt agg att aat gcc atg aga tgc      192
 Ser Gly Ala Phe Phe Lys Lys Cys Val Arg Ile Asn Ala Met Arg Cys
      50                  55                  60

 cac acc ctc ctc atc ttt tcc ctg cct tcc atc ctc ctg tac caa ttg      240
 His Thr Leu Leu Ile Phe Ser Leu Pro Ser Ile Leu Leu Tyr Gln Leu
  65                  70                  75                  80

 atg cca gac atc atg agg gcc gtt acc att acg atc cat ctc cga ttc      288
 Met Pro Asp Ile Met Arg Ala Val Thr Ile Thr Ile His Leu Arg Phe
                  85                  90                  95

 ctc cat tgc ata tgg aga gga ctc agt att atg aag atc att aat atc      336
 Leu His Cys Ile Trp Arg Gly Leu Ser Ile Met Lys Ile Ile Asn Ile
             100                 105                 110

 agc tgt gag aca gag tgc act gga aat agc agc acg gtc cag gag cag      384
 Ser Cys Glu Thr Glu Cys Thr Gly Asn Ser Ser Thr Val Gln Glu Gln
         115                 120                 125

 ata ttg act gag gta ttc acg ttc act gaa ccg gaa gcc gcc gac tct      432
 Ile Leu Thr Glu Val Phe Thr Phe Thr Glu Pro Glu Ala Ala Asp Ser
     130                 135                 140

 ata gag gct gct gtc aaa cct gtt gcg ggg gcc tgg gag gtc ctt gag      480
 Ile Glu Ala Ala Val Lys Pro Val Ala Gly Ala Trp Glu Val Leu Glu
 145                 150                 155                 160

 gga aat cag tac tca aca agg caa cgg aag cca ggt gac ttt ggc ctt      528
 Gly Asn Gln Tyr Ser Thr Arg Gln Arg Lys Pro Gly Asp Phe Gly Leu
                 165                 170                 175

 aac caa ccc aga gct cta gga atg gca gca gca gca gga atg aag aga      576
 Asn Gln Pro Arg Ala Leu Gly Met Ala Ala Ala Ala Gly Met Lys Arg
             180                 185                 190

 agg aac ttg gtg gtc cag gag gtt atg cag act ggc cat tct aga agt      624
 Arg Asn Leu Val Val Gln Glu Val Met Gln Thr Gly His Ser Arg Ser
         195                 200                 205

 ggc tgt ctc agg gtg tgg ctg tgg cta tgg ggc agc agg tgt gag ggg      672
 Gly Cys Leu Arg Val Trp Leu Trp Leu Trp Gly Ser Arg Cys Glu Gly
     210                 215                 220

 att ttg agg aat ctc tct cca gaa gca gat cag gat atc gtg gta gca      720
 Ile Leu Arg Asn Leu Ser Pro Glu Ala Asp Gln Asp Ile Val Val Ala
 225                 230                 235                 240

 agg act tcc gcc tta tct agt agc cct acg tat ccg gac ctg ccc ttc      768
 Arg Thr Ser Ala Leu Ser Ser Ser Pro Thr Tyr Pro Asp Leu Pro Phe
                 245                 250                 255

 att agg atc tcc cca cac cgg aac ccc act gct gct tcc gag tct ccc      816
 Ile Arg Ile Ser Pro His Arg Asn Pro Thr Ala Ala Ser Glu Ser Pro
             260                 265                 270

 ttc agc cct cca cat ccc tac att aat ccc tac atg gac tat atc cgc      864
 Phe Ser Pro Pro His Pro Tyr Ile Asn Pro Tyr Met Asp Tyr Ile Arg
         275                 280                 285

 tcc ttg cac agc agc cca tcg ctc tcc atg atc tca gca acc cgt ggg      912
 Ser Leu His Ser Ser Pro Ser Leu Ser Met Ile Ser Ala Thr Arg Gly
     290                 295                 300

 ctg agc cct aca gat ggt aag tcc agg atg gat tct gct tct gga gat      960
 Leu Ser Pro Thr Asp Gly Lys Ser Arg Met Asp Ser Ala Ser Gly Asp
 305                 310                 315                 320

 cat gca gcc tcc tcc ccg ctc ctc act cgg gac gtg tat aaa gta gac     1008
 His Ala Ala Ser Ser Pro Leu Leu Thr Arg Asp Val Tyr Lys Val Asp
                 325                 330                 335

 ctg atg ttt acg ccc cat gca gga gtc agc cca gca gaa tac tat cat     1056
 Leu Met Phe Thr Pro His Ala Gly Val Ser Pro Ala Glu Tyr Tyr His
             340                 345                 350

 cag atg gcc ctg cta act ggc cag cgc agc ccc tat gca gac att att     1104
 Gln Met Ala Leu Leu Thr Gly Gln Arg Ser Pro Tyr Ala Asp Ile Ile
         355                 360                 365

 ccc tca gct gcc acc gcc ggc acg ggg gcc atc cac atg gaa tat ctt     1152
 Pro Ser Ala Ala Thr Ala Gly Thr Gly Ala Ile His Met Glu Tyr Leu
     370                 375                 380

 cat gct atg gat agc acc aga ttc tcc agc ccc agg ctg tca gcc agg     1200
 His Ala Met Asp Ser Thr Arg Phe Ser Ser Pro Arg Leu Ser Ala Arg
 385                 390                 395                 400

 ccg agc cga aaa cgt aca ctg tcc ata tca cca ctc tcc gat cat agc     1248
 Pro Ser Arg Lys Arg Thr Leu Ser Ile Ser Pro Leu Ser Asp His Ser
                 405                 410                 415

 ttt gac ctt cag acc atg ata agg acg tct ccc aac tcc ttg gtc acg     1296
 Phe Asp Leu Gln Thr Met Ile Arg Thr Ser Pro Asn Ser Leu Val Thr
             420                 425                 430

 att ctc aat aat tcc cgt agc agc tct tca gca agt ggc tcc tat ggt     1344
 Ile Leu Asn Asn Ser Arg Ser Ser Ser Ser Ala Ser Gly Ser Tyr Gly
         435                 440                 445

 cac tta tct gca agt gca atc agc ctc ctt agt cct tac ggt ctc ctg     1392
 His Leu Ser Ala Ser Ala Ile Ser Leu Leu Ser Pro Tyr Gly Leu Leu
     450                 455                 460

 gtc tcc tca tct tca ccc agc cct tgc agt cta att gtt gat gtg gat     1440
 Val Ser Ser Ser Ser Pro Ser Pro Cys Ser Leu Ile Val Asp Val Asp
 465                 470                 475                 480

 ttt aga gaa cat tta ttc ccg tca cct ggt ttt acc agc aaa aag gtg     1488
 Phe Arg Glu His Leu Phe Pro Ser Pro Gly Phe Thr Ser Lys Lys Val
                 485                 490                 495

 gag gcc ctg aat ggg gat atg gcc aaa gta tgt gaa gag ctt tca gaa     1536
 Glu Ala Leu Asn Gly Asp Met Ala Lys Val Cys Glu Glu Leu Ser Glu
             500                 505                 510

 ccc cta ccc ctg ctc ccc gag gac aag gag gat cgt aga cct agg aaa     1584
 Pro Leu Pro Leu Leu Pro Glu Asp Lys Glu Asp Arg Arg Pro Arg Lys
         515                 520                 525

 ctg cgc aag aac gtg gag gct gga gta aat tgt gtc acg ggc tct gaa     1632
 Leu Arg Lys Asn Val Glu Ala Gly Val Asn Cys Val Thr Gly Ser Glu
     530                 535                 540

 atg gat ctt tcc tct tgc ata tcg cca gac agc aac aac ctt gct ggt     1680
 Met Asp Leu Ser Ser Cys Ile Ser Pro Asp Ser Asn Asn Leu Ala Gly
 545                 550                 555                 560

 tac act tca atg cct gca tat ggc ttt tat cat cta gcc ctg gat tgg     1728
 Tyr Thr Ser Met Pro Ala Tyr Gly Phe Tyr His Leu Ala Leu Asp Trp
                 565                 570                 575

 gac ctg aat cta cac aag atg aat tct caa aat gac ttg tat tgg cat     1776
 Asp Leu Asn Leu His Lys Met Asn Ser Gln Asn Asp Leu Tyr Trp His
             580                 585                 590

 tgc tgt gaa gct gcc aca ggg gaa cag ccc gaa gga aca acc ctt gtc     1824
 Cys Cys Glu Ala Ala Thr Gly Glu Gln Pro Glu Gly Thr Thr Leu Val
         595                 600                 605

 aag gag gaa ggg gac aaa gat gaa agc aaa cag gag cct gaa gtc atc     1872
 Lys Glu Glu Gly Asp Lys Asp Glu Ser Lys Gln Glu Pro Glu Val Ile
     610                 615                 620

 tat gag aca aac tgc cac tgg gaa ggc tgc gcg agg gag ttc gac acc     1920
 Tyr Glu Thr Asn Cys His Trp Glu Gly Cys Ala Arg Glu Phe Asp Thr
 625                 630                 635                 640

 caa gag cag ctt gtg cac ccc aat ccc cag cag cat aac cct gca ggg     1968
 Gln Glu Gln Leu Val His Pro Asn Pro Gln Gln His Asn Pro Ala Gly
                 645                 650                 655

 ccc ttg gca atc gca ctg ggg gat gtt gtc ttc tac ctg tgg ggc aga     2016
 Pro Leu Ala Ile Ala Leu Gly Asp Val Val Phe Tyr Leu Trp Gly Arg
             660                 665                 670

 acc gca gag aaa gtg aga tgt att tct gtt agc acc cag ctt caa ctg     2064
 Thr Ala Glu Lys Val Arg Cys Ile Ser Val Ser Thr Gln Leu Gln Leu
         675                 680                 685

 ggt ggc gtt caa gtc tct gta atc ctc cat ttg tct ccg tga             2106
 Gly Gly Val Gln Val Ser Val Ile Leu His Leu Ser Pro 
     690                 695                 700





      <210> 662
      <211> 654
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (1)..(654)

      <400> 662
  atg ccc cgc tac gtc ccc ctt ctg ctg ctc ctg ctt ctc ctg agg tgt      48
  Met Pro Arg Tyr Val Pro Leu Leu Leu Leu Leu Leu Leu Leu Arg Cys
    1               5                  10                  15

 tca gaa cgg ggt gga gga gtt aat ttt ggt gag aag gat gca aaa gtc       96
 Ser Glu Arg Gly Gly Gly Val Asn Phe Gly Glu Lys Asp Ala Lys Val
              20                  25                  30

 ccc ggg acc tgg aga gat gga gtc agg gtc cct gga gaa gga gcc tct      144
 Pro Gly Thr Trp Arg Asp Gly Val Arg Val Pro Gly Glu Gly Ala Ser
          35                  40                  45

 tgg gac tca gac agg gcc agt ccc gag cga agg tac gga ata gac cca      192
 Trp Asp Ser Asp Arg Ala Ser Pro Glu Arg Arg Tyr Gly Ile Asp Pro
      50                  55                  60

 ggg acc acc aag gac tcc atc act gca gac cca agg acc aca gag gac      240
 Gly Thr Thr Lys Asp Ser Ile Thr Ala Asp Pro Arg Thr Thr Glu Asp
  65                  70                  75                  80

 tcc gtc act gca gac cca ggg acc acc aaa cac tcc atc act gta gac      288
 Ser Val Thr Ala Asp Pro Gly Thr Thr Lys His Ser Ile Thr Val Asp
                  85                  90                  95

 cca ggg acc act gag gac tct gtc act gca gac cca ggg acc acc aaa      336
 Pro Gly Thr Thr Glu Asp Ser Val Thr Ala Asp Pro Gly Thr Thr Lys
             100                 105                 110

 cac tcc atc act gca gac cca ggg acc acc gag gac tcc gtc act gca      384
 His Ser Ile Thr Ala Asp Pro Gly Thr Thr Glu Asp Ser Val Thr Ala
         115                 120                 125

 gac cca ggg acc aca gaa gat gaa acc act aaa cat gtc aca gca gtg      432
 Asp Pro Gly Thr Thr Glu Asp Glu Thr Thr Lys His Val Thr Ala Val
     130                 135                 140

 aaa ccc acc agg ctc ctg aca ccc atg gga att atc ctc ata tcc ctg      480
 Lys Pro Thr Arg Leu Leu Thr Pro Met Gly Ile Ile Leu Ile Ser Leu
 145                 150                 155                 160

 gct gca acc aca gtc act gtt gtg ctc ttt gtt gga ttg ggc ttc att      528
 Ala Ala Thr Thr Val Thr Val Val Leu Phe Val Gly Leu Gly Phe Ile
                 165                 170                 175

 gtg agg aca tat aag cct gtg cat ggc tat gag aac aca gtg gag agc      576
 Val Arg Thr Tyr Lys Pro Val His Gly Tyr Glu Asn Thr Val Glu Ser
             180                 185                 190

 cat gta aat agc ttt tgc ctt caa ggt gcc tgg cag aag cga atg aat      624
 His Val Asn Ser Phe Cys Leu Gln Gly Ala Trp Gln Lys Arg Met Asn
         195                 200                 205

 att gct gtc atg tac atg caa acg ttg tga                              654
 Ile Ala Val Met Tyr Met Gln Thr Leu 
     210                 215





      <210> 663
      <211> 1167
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (1)..(1167)

      <400> 663
  atg ggg ctg agg gct ggg gtg gtg act gcc agc aag gcc ttt ttg agc      48
  Met Gly Leu Arg Ala Gly Val Val Thr Ala Ser Lys Ala Phe Leu Ser
    1               5                  10                  15

 ctg agt ctt gaa aaa gga gaa atc agc cag aca atg aac aca gga gga       96
 Leu Ser Leu Glu Lys Gly Glu Ile Ser Gln Thr Met Asn Thr Gly Gly
              20                  25                  30

 gaa agg gaa ttc cag gca gag gta cag aag gag caa agg cag aaa agc      144
 Glu Arg Glu Phe Gln Ala Glu Val Gln Lys Glu Gln Arg Gln Lys Ser
          35                  40                  45

 act ggg cgg tac cag tgc agt tta cgg gag gtt cag ttt tgc aag aaa      192
 Thr Gly Arg Tyr Gln Cys Ser Leu Arg Glu Val Gln Phe Cys Lys Lys
      50                  55                  60

 aga atg ttt cag gca ggg gac aag gca agg aga tgg gaa ggg agt gaa      240
 Arg Met Phe Gln Ala Gly Asp Lys Ala Arg Arg Trp Glu Gly Ser Glu
  65                  70                  75                  80

 gaa agc ttt gac tct gtt ggg tca tta caa atg gcc agc agc ctg atg      288
 Glu Ser Phe Asp Ser Val Gly Ser Leu Gln Met Ala Ser Ser Leu Met
                  85                  90                  95

 atg aaa ata gca aag acc tgc tcg ctc ggg tta aat cgg ctg cca gag      336
 Met Lys Ile Ala Lys Thr Cys Ser Leu Gly Leu Asn Arg Leu Pro Glu
             100                 105                 110

 gcc aag tta aag gct ttc ccc aca ccg cgc gtc acc tcc ctc tgc cca      384
 Ala Lys Leu Lys Ala Phe Pro Thr Pro Arg Val Thr Ser Leu Cys Pro
         115                 120                 125

 ggc aga ggg tcc cgc tgg ccc cgc agc ttc ccg gcc ggg cgc aag gtc      432
 Gly Arg Gly Ser Arg Trp Pro Arg Ser Phe Pro Ala Gly Arg Lys Val
     130                 135                 140

 agg gag cag ggc cgg tgg cgc gcg gag ccc cgg gga gcg tcc ccc gcc      480
 Arg Glu Gln Gly Arg Trp Arg Ala Glu Pro Arg Gly Ala Ser Pro Ala
 145                 150                 155                 160

 gag ggc agc gcc ggc cgc gcc cgg gac tca ccg cgc agc ctg tac tca      528
 Glu Gly Ser Ala Gly Arg Ala Arg Asp Ser Pro Arg Ser Leu Tyr Ser
                 165                 170                 175

 ccg cgc tcg ctg gat ccc cag ggg gcg gcc gcg gag ggc ggt gcg gcc      576
 Pro Arg Ser Leu Asp Pro Gln Gly Ala Ala Ala Glu Gly Gly Ala Ala
             180                 185                 190

 gca acc gga gcg gga gcc tgg tct cgg cgg cgc ggg gag tcg gag gac      624
 Ala Thr Gly Ala Gly Ala Trp Ser Arg Arg Arg Gly Glu Ser Glu Asp
         195                 200                 205

 gca gcc aag cgg cgg cgg cga gga ggg tca cag ccg gaa aga ggc agc      672
 Ala Ala Lys Arg Arg Arg Arg Gly Gly Ser Gln Pro Glu Arg Gly Ser
     210                 215                 220

 ggt ggc gcc tgc aga cgc cgc gca gcc cgg gca gcc cca cag cgc aag      720
 Gly Gly Ala Cys Arg Arg Arg Ala Ala Arg Ala Ala Pro Gln Arg Lys
 225                 230                 235                 240

 ctg gct gcc gcg gcg gcg ggg gct tta tcg gcg gcg ccg cgc ggg ccc      768
 Leu Ala Ala Ala Ala Ala Gly Ala Leu Ser Ala Ala Pro Arg Gly Pro
                 245                 250                 255

 ccg ccc ctt cct gcc gcc ccc gcc ccc ggc ccg cct tgc ccc gcc ttc      816
 Pro Pro Leu Pro Ala Ala Pro Ala Pro Gly Pro Pro Cys Pro Ala Phe
             260                 265                 270

 ccg ccg cct cct ttg tgt ggc cgc ggg ccg cag cgt ccc cgc gcc cgg      864
 Pro Pro Pro Pro Leu Cys Gly Arg Gly Pro Gln Arg Pro Arg Ala Arg
         275                 280                 285

 cct cca gga cgc ccc ctc tcc gcc tgc gac ttc tcg gat gcc gcc ccg      912
 Pro Pro Gly Arg Pro Leu Ser Ala Cys Asp Phe Ser Asp Ala Ala Pro
     290                 295                 300

 cca ggg gtc cgt gtc gtg ggg ctg cgc ccg gaa cgc gcc ggg gag acg      960
 Pro Gly Val Arg Val Val Gly Leu Arg Pro Glu Arg Ala Gly Glu Thr
 305                 310                 315                 320

 cgc aga ccc cga ggt gcg gcg cca gcc cgg gcc cag ctg cac aca tgc     1008
 Arg Arg Pro Arg Gly Ala Ala Pro Ala Arg Ala Gln Leu His Thr Cys
                 325                 330                 335

 gat gag gcc aac gat gag gtc tcc caa agg aaa gtg att gaa gac aaa     1056
 Asp Glu Ala Asn Asp Glu Val Ser Gln Arg Lys Val Ile Glu Asp Lys
             340                 345                 350

 gac cca ttc tgc cag tgg gat atg ctg gga ata cca act ata ctt gtt     1104
 Asp Pro Phe Cys Gln Trp Asp Met Leu Gly Ile Pro Thr Ile Leu Val
         355                 360                 365

 act gag tgt gca tgg ctg gtg ttg gcc agc ctt cct gat gcc agc aag     1152
 Thr Glu Cys Ala Trp Leu Val Leu Ala Ser Leu Pro Asp Ala Ser Lys
     370                 375                 380

 agg aga cag aag taa                                                 1167
 Arg Arg Gln Lys 
 385





      <210> 664
      <211> 2214
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (1)..(2214)

      <400> 664
  atg ctt att atc cac tgg gta aca gtg gtt acc cta gag gca aca att      48
  Met Leu Ile Ile His Trp Val Thr Val Val Thr Leu Glu Ala Thr Ile
    1               5                  10                  15

 att atc cac cag gta aca gtg ggt acc cta gag gca aca cta att atc       96
 Ile Ile His Gln Val Thr Val Gly Thr Leu Glu Ala Thr Leu Ile Ile
              20                  25                  30

 cac cgg gta aca gtg gtt acc cgt gag gca aca att att atc cag cag      144
 His Arg Val Thr Val Val Thr Arg Glu Ala Thr Ile Ile Ile Gln Gln
          35                  40                  45

 gta aca gtg gat acc cac aat gca aca att att atc cac cag gta aca      192
 Val Thr Val Asp Thr His Asn Ala Thr Ile Ile Ile His Gln Val Thr
      50                  55                  60

 gtg gtt acc cgc gag gca aca ctt att atc cac tgg gta aca gtg gtt      240
 Val Val Thr Arg Glu Ala Thr Leu Ile Ile His Trp Val Thr Val Val
  65                  70                  75                  80

 acc aat gag gca ata ctt att atc cac cga gta aca gtg gtt acc cac      288
 Thr Asn Glu Ala Ile Leu Ile Ile His Arg Val Thr Val Val Thr His
                  85                  90                  95

 aag gca tta ctt att ctc cac cag gta act gtg gtt acc cac gag gca      336
 Lys Ala Leu Leu Ile Leu His Gln Val Thr Val Val Thr His Glu Ala
             100                 105                 110

 ata ttt att atc cac cgg gta aca gcg gtt acc cac aag gca ata ctt      384
 Ile Phe Ile Ile His Arg Val Thr Ala Val Thr His Lys Ala Ile Leu
         115                 120                 125

 agt atc cgg tgg gta atg gtg gtt acc cat gag gaa ata ttt atc atc      432
 Ser Ile Arg Trp Val Met Val Val Thr His Glu Glu Ile Phe Ile Ile
     130                 135                 140

 cac cag gta aca gtg gtt atc cac aag gaa ata ctt att att tac cag      480
 His Gln Val Thr Val Val Ile His Lys Glu Ile Leu Ile Ile Tyr Gln
 145                 150                 155                 160

 gta aca gtg gtt acc caa gag gca aca ctt att atc cac cag gta aca      528
 Val Thr Val Val Thr Gln Glu Ala Thr Leu Ile Ile His Gln Val Thr
                 165                 170                 175

 gtg gtt acc cac aag gca ata ctt agt gtc cac cgg gta aca atg gtt      576
 Val Val Thr His Lys Ala Ile Leu Ser Val His Arg Val Thr Met Val
             180                 185                 190

 acc cac gag gca ata ctt act atc cat cat gta aca gtg gtt acc cac      624
 Thr His Glu Ala Ile Leu Thr Ile His His Val Thr Val Val Thr His
         195                 200                 205

 gag gca aca ctt att gtc cac tgg gta aca gtg gtt acc cac gaa gca      672
 Glu Ala Thr Leu Ile Val His Trp Val Thr Val Val Thr His Glu Ala
     210                 215                 220

 aca ctt att ttc cac agg gta aca gta gtt aac tgc gag gca ata ctt      720
 Thr Leu Ile Phe His Arg Val Thr Val Val Asn Cys Glu Ala Ile Leu
 225                 230                 235                 240

 att ttc cag cag gta tca gta gtt acc tat gag gca ata ctt att atc      768
 Ile Phe Gln Gln Val Ser Val Val Thr Tyr Glu Ala Ile Leu Ile Ile
                 245                 250                 255

 cag cag ata aca gta gtt acc tat gag gca att ctt att atc cac cag      816
 Gln Gln Ile Thr Val Val Thr Tyr Glu Ala Ile Leu Ile Ile His Gln
             260                 265                 270

 gta gca gta gtt acc tat gag gca ata ctg tta tcc acc aca gac ttg      864
 Val Ala Val Val Thr Tyr Glu Ala Ile Leu Leu Ser Thr Thr Asp Leu
         275                 280                 285

 tta aat tgt tgc cac caa aat act ggt agt gat atg gac aat gaa gtc      912
 Leu Asn Cys Cys His Gln Asn Thr Gly Ser Asp Met Asp Asn Glu Val
     290                 295                 300

 cag tct gag gag gtc tca gaa gga gat gag gaa ctt act ggg aat cgg      960
 Gln Ser Glu Glu Val Ser Glu Gly Asp Glu Glu Leu Thr Gly Asn Arg
 305                 310                 315                 320

 agt aaa ggt cag ttt tgt tat ggt tta gtg aag aac ttg gag gca ctg     1008
 Ser Lys Gly Gln Phe Cys Tyr Gly Leu Val Lys Asn Leu Glu Ala Leu
                 325                 330                 335

 tac ccc tgt cca agg gat ctg tgg aac ttt gac ctt gaa agt gat gat     1056
 Tyr Pro Cys Pro Arg Asp Leu Trp Asn Phe Asp Leu Glu Ser Asp Asp
             340                 345                 350

 tta aga gtc gaa gaa ctc ttc ctc aca ggt aat tca tct gtc aga gaa     1104
 Leu Arg Val Glu Glu Leu Phe Leu Thr Gly Asn Ser Ser Val Arg Glu
         355                 360                 365

 acg gat gga gat gag ctt gtc agg gtc ttc ttc att ctc atc gcc acc     1152
 Thr Asp Gly Asp Glu Leu Val Arg Val Phe Phe Ile Leu Ile Ala Thr
     370                 375                 380

 ctc ttg agg gac agc atc ctc aga atc acc tgc att tgg act gca gaa     1200
 Leu Leu Arg Asp Ser Ile Leu Arg Ile Thr Cys Ile Trp Thr Ala Glu
 385                 390                 395                 400

 gcc aga tgc ctt gaa ctt ctt tgc atg gtg cag gcc tcc agc cca att     1248
 Ala Arg Cys Leu Glu Leu Leu Cys Met Val Gln Ala Ser Ser Pro Ile
                 405                 410                 415

 cac agc agt gtc cat ctg ctg ctc att aag ttt cac agc act tgc cac     1296
 His Ser Ser Val His Leu Leu Leu Ile Lys Phe His Ser Thr Cys His
             420                 425                 430

 aga gcc acc agt aga caa ctg aca gaa gtc aaa cag gcc atc aaa tgc     1344
 Arg Ala Thr Ser Arg Gln Leu Thr Glu Val Lys Gln Ala Ile Lys Cys
         435                 440                 445

 tgg aca gtc ctc act aac gtt gaa tct ctg cat ccg ctt gct gtg ctc     1392
 Trp Thr Val Leu Thr Asn Val Glu Ser Leu His Pro Leu Ala Val Leu
     450                 455                 460

 aga cac gta atc tgg ata gat gga gca caa gaa ttt aat gta gtc atc     1440
 Arg His Val Ile Trp Ile Asp Gly Ala Gln Glu Phe Asn Val Val Ile
 465                 470                 475                 480

 act gtg gta ctt ggt cat ctc ctc agc att ggc ttt gtt tgg tct gct     1488
 Thr Val Val Leu Gly His Leu Leu Ser Ile Gly Phe Val Trp Ser Ala
                 485                 490                 495

 cta aac tta tcc atc tcc ctc cat tac tgg aac aac tcc aca aag tcc     1536
 Leu Asn Leu Ser Ile Ser Leu His Tyr Trp Asn Asn Ser Thr Lys Ser
             500                 505                 510

 tta ttc cct aaa aca cca ctg ata tca tta aag cca cta aca gag act     1584
 Leu Phe Pro Lys Thr Pro Leu Ile Ser Leu Lys Pro Leu Thr Glu Thr
         515                 520                 525

 gaa ctc aga ata aag gaa atc ata gag aaa cta gat cag cag atc cca     1632
 Glu Leu Arg Ile Lys Glu Ile Ile Glu Lys Leu Asp Gln Gln Ile Pro
     530                 535                 540

 ccc aga cct ttc acc cac gtg aac acc acc acc agc gcc aca cat agc     1680
 Pro Arg Pro Phe Thr His Val Asn Thr Thr Thr Ser Ala Thr His Ser
 545                 550                 555                 560

 aca gcc acc atc ctc aac cct cga gat acg tac tgc agg gga gac cag     1728
 Thr Ala Thr Ile Leu Asn Pro Arg Asp Thr Tyr Cys Arg Gly Asp Gln
                 565                 570                 575

 ctg cac atc ctg ctg gag gtg agg gac cac ttg gga cgc agg aag caa     1776
 Leu His Ile Leu Leu Glu Val Arg Asp His Leu Gly Arg Arg Lys Gln
             580                 585                 590

 tat ggc ggg gat ttc ctg agg gcc agg atg tct tcc cca gcg ctg atg     1824
 Tyr Gly Gly Asp Phe Leu Arg Ala Arg Met Ser Ser Pro Ala Leu Met
         595                 600                 605

 gca ggt gct tca gga aag gtg act gac ttc aac aac ggc acc tac ctg     1872
 Ala Gly Ala Ser Gly Lys Val Thr Asp Phe Asn Asn Gly Thr Tyr Leu
     610                 615                 620

 gtc agc ttc act ctg ttc tgg gag ggc cag gtc tct ctg tct ctg ctg     1920
 Val Ser Phe Thr Leu Phe Trp Glu Gly Gln Val Ser Leu Ser Leu Leu
 625                 630                 635                 640

 ctc atc cac ccc agt gaa ggg gtg tca gct ctc tgg agt gca agg aac     1968
 Leu Ile His Pro Ser Glu Gly Val Ser Ala Leu Trp Ser Ala Arg Asn
                 645                 650                 655

 caa ggc tat gac agg gtg atc ttc act ggc cag ttt gtc aat ggc act     2016
 Gln Gly Tyr Asp Arg Val Ile Phe Thr Gly Gln Phe Val Asn Gly Thr
             660                 665                 670

 tcc caa gtc cac tct gaa tgt ggc ctg atc cta aac aca aat gct gaa     2064
 Ser Gln Val His Ser Glu Cys Gly Leu Ile Leu Asn Thr Asn Ala Glu
         675                 680                 685

 ttg tgc cag tac ctg gac aac aga gac caa gaa ggc ttc tac tgt gtg     2112
 Leu Cys Gln Tyr Leu Asp Asn Arg Asp Gln Glu Gly Phe Tyr Cys Val
     690                 695                 700

 agg cct caa cac atg ccc tgt gct gca ctc act cac atg tat tct aag     2160
 Arg Pro Gln His Met Pro Cys Ala Ala Leu Thr His Met Tyr Ser Lys
 705                 710                 715                 720

 aac aag aaa gtt tct tat ctt agc aaa caa gaa aag agc ctc ttt gaa     2208
 Asn Lys Lys Val Ser Tyr Leu Ser Lys Gln Glu Lys Ser Leu Phe Glu
                 725                 730                 735

 agg taa                                                             2214
 Arg 






      <210> 665
      <211> 2412
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (1)..(2412)

      <400> 665
  atg gct gtg tat gtg tgt gtg gga gtc tca ttg acc aca gtg ctg aca      48
  Met Ala Val Tyr Val Cys Val Gly Val Ser Leu Thr Thr Val Leu Thr
    1               5                  10                  15

 cag ttt ccc ttg gtg gaa gta aag aag tac agt gtg gca aag ggg acc       96
 Gln Phe Pro Leu Val Glu Val Lys Lys Tyr Ser Val Ala Lys Gly Thr
              20                  25                  30

 gag gag agg aac atc aca gtg gag aaa ctg gtg tat acc aac ttc acc      144
 Glu Glu Arg Asn Ile Thr Val Glu Lys Leu Val Tyr Thr Asn Phe Thr
          35                  40                  45

 agg cga tca ggg cca acg ttg aca gcc tcc caa act gct ggg att aca      192
 Arg Arg Ser Gly Pro Thr Leu Thr Ala Ser Gln Thr Ala Gly Ile Thr
      50                  55                  60

 ggc gtg aac cac cgc acc cgg ccc cgc att tca ctg gat ctt cag aac      240
 Gly Val Asn His Arg Thr Arg Pro Arg Ile Ser Leu Asp Leu Gln Asn
  65                  70                  75                  80

 agg aat ggc ttc ctt ggg gag ggt ccc aaa aag tgc gaa tca aaa cag      288
 Arg Asn Gly Phe Leu Gly Glu Gly Pro Lys Lys Cys Glu Ser Lys Gln
                  85                  90                  95

 aga ttt ggg aac cac cag gca tgc ata gtt ccg gtc cca gac cct ggc      336
 Arg Phe Gly Asn His Gln Ala Cys Ile Val Pro Val Pro Asp Pro Gly
             100                 105                 110

 ttt gta gca tac att ttc aag gag gac tct tgg gcc acc aca gat act      384
 Phe Val Ala Tyr Ile Phe Lys Glu Asp Ser Trp Ala Thr Thr Asp Thr
         115                 120                 125

 gcc cta tcc att gct att ttt gat gac aag cag atg ccc agt gtc ggg      432
 Ala Leu Ser Ile Ala Ile Phe Asp Asp Lys Gln Met Pro Ser Val Gly
     130                 135                 140

 aag gca gcc cag gat cac agc agc acc cac cga gtc aga agg cac cga      480
 Lys Ala Ala Gln Asp His Ser Ser Thr His Arg Val Arg Arg His Arg
 145                 150                 155                 160

 acc cac cca cat tct ctg aac tat ctc act gcc ggg gag ccc cag agc      528
 Thr His Pro His Ser Leu Asn Tyr Leu Thr Ala Gly Glu Pro Gln Ser
                 165                 170                 175

 tgc ccc ggg agg gcc ggg gcc gag cgg gaa ccc tac ctc gag att ata      576
 Cys Pro Gly Arg Ala Gly Ala Glu Arg Glu Pro Tyr Leu Glu Ile Ile
             180                 185                 190

 gat act cgg agg aga gca ccc cag cag act tgg gac ccc gag ccc aga      624
 Asp Thr Arg Arg Arg Ala Pro Gln Gln Thr Trp Asp Pro Glu Pro Arg
         195                 200                 205

 gcc ctg gct cac ccc tgc atg ctc gag gac aag act cgt ggc cac ccc      672
 Ala Leu Ala His Pro Cys Met Leu Glu Asp Lys Thr Arg Gly His Pro
     210                 215                 220

 tct gtg ttc agc agt gcc cag ccc cag gac acc ccg aag gcc act gtc      720
 Ser Val Phe Ser Ser Ala Gln Pro Gln Asp Thr Pro Lys Ala Thr Val
 225                 230                 235                 240

 tgt gag cgt gga agc cag cat gtg agc ggg gac gca tca cgt cct ctg      768
 Cys Glu Arg Gly Ser Gln His Val Ser Gly Asp Ala Ser Arg Pro Leu
                 245                 250                 255

 cca gaa gca ctg ctc cct ccc aag cag cag cac ctg cgc ctg cag acg      816
 Pro Glu Ala Leu Leu Pro Pro Lys Gln Gln His Leu Arg Leu Gln Thr
             260                 265                 270

 gcc acc atg gag acc tcg cgc tcc ccc tcg ccc cag ttc gcc ccc cag      864
 Ala Thr Met Glu Thr Ser Arg Ser Pro Ser Pro Gln Phe Ala Pro Gln
         275                 280                 285

 aaa ctg acg gac aaa cct ccc ctg ctc atc cag gat gag gat tca acc      912
 Lys Leu Thr Asp Lys Pro Pro Leu Leu Ile Gln Asp Glu Asp Ser Thr
     290                 295                 300

 agg tac tgt cct gcg acg gtt caa gcg att ctc atg ctt cag ctt ccc      960
 Arg Tyr Cys Pro Ala Thr Val Gln Ala Ile Leu Met Leu Gln Leu Pro
 305                 310                 315                 320

 gaa att gag cgg gtg atg gac aac aac acc acg gtg aag atg gtg ccc     1008
 Glu Ile Glu Arg Val Met Asp Asn Asn Thr Thr Val Lys Met Val Pro
                 325                 330                 335

 atc aag atc gtg cac tcg gag agc cag cca gag aag gag agc cgc cag     1056
 Ile Lys Ile Val His Ser Glu Ser Gln Pro Glu Lys Glu Ser Arg Gln
             340                 345                 350

 agc ctg gca tgc ccc gcc gag cca cct gcc ctg ccc cac ggg ctg gag     1104
 Ser Leu Ala Cys Pro Ala Glu Pro Pro Ala Leu Pro His Gly Leu Glu
         355                 360                 365

 aaa gac cag atc aag acg ctg agc aca tct gag cag ttc tac tcg cgc     1152
 Lys Asp Gln Ile Lys Thr Leu Ser Thr Ser Glu Gln Phe Tyr Ser Arg
     370                 375                 380

 ttc tgt ctg tac acg cgg cag ggt gct gag ccc gag gcc cca cat agg     1200
 Phe Cys Leu Tyr Thr Arg Gln Gly Ala Glu Pro Glu Ala Pro His Arg
 385                 390                 395                 400

 gcc cag ccg gct gag ccc cag ccc ctg ggc acc cag gtg ccc ccc gag     1248
 Ala Gln Pro Ala Glu Pro Gln Pro Leu Gly Thr Gln Val Pro Pro Glu
                 405                 410                 415

 aaa gac cgc tgc acc tcc cct cca ggg ctc agc tac atg aag gcc aaa     1296
 Lys Asp Arg Cys Thr Ser Pro Pro Gly Leu Ser Tyr Met Lys Ala Lys
             420                 425                 430

 gag aag act gtg gaa gac ctg aag tcg gag gag ctg gcc agg gag atc     1344
 Glu Lys Thr Val Glu Asp Leu Lys Ser Glu Glu Leu Ala Arg Glu Ile
         435                 440                 445

 gtg ggg aag gat aag tcc ctg gcc gac atc ctg gat ccc agt gtg aag     1392
 Val Gly Lys Asp Lys Ser Leu Ala Asp Ile Leu Asp Pro Ser Val Lys
     450                 455                 460

 atc aaa acc act atg gac ttg atg gaa ggc atc ttc ccc aaa gac gag     1440
 Ile Lys Thr Thr Met Asp Leu Met Glu Gly Ile Phe Pro Lys Asp Glu
 465                 470                 475                 480

 cac ctc ctg gaa gaa gcc cag caa cgg agg aag ctg ctc ccc aaa atc     1488
 His Leu Leu Glu Glu Ala Gln Gln Arg Arg Lys Leu Leu Pro Lys Ile
                 485                 490                 495

 ccc tct cct aga agc aca gag gag agg aaa gag gag ccc agc gtg cct     1536
 Pro Ser Pro Arg Ser Thr Glu Glu Arg Lys Glu Glu Pro Ser Val Pro
             500                 505                 510

 gcg gcc gtg tcc ctg gcc acc aat tct acc tac tac agc acg tcg gcc     1584
 Ala Ala Val Ser Leu Ala Thr Asn Ser Thr Tyr Tyr Ser Thr Ser Ala
         515                 520                 525

 ccc aag gcg gag ctg ctg atc aag atg aag gac ctg cag gag cag cag     1632
 Pro Lys Ala Glu Leu Leu Ile Lys Met Lys Asp Leu Gln Glu Gln Gln
     530                 535                 540

 gag cac gaa gag gat tcg gga agc gac ttg gac cac gac ctg tcg gtg     1680
 Glu His Glu Glu Asp Ser Gly Ser Asp Leu Asp His Asp Leu Ser Val
 545                 550                 555                 560

 aag aag gtg cgc caa ggt ggc agt gag cag tgt ggc cgg ggt ggg ggc     1728
 Lys Lys Val Arg Gln Gly Gly Ser Glu Gln Cys Gly Arg Gly Gly Gly
                 565                 570                 575

 cgg cct aac cag tgt ctc cgt gtt ccc ttg cca tcc cgt gcc caa cag     1776
 Arg Pro Asn Gln Cys Leu Arg Val Pro Leu Pro Ser Arg Ala Gln Gln
             580                 585                 590

 cag gag ctc atc gag agc atc agc cgc aag ctg cag gtg ctc cgg gag     1824
 Gln Glu Leu Ile Glu Ser Ile Ser Arg Lys Leu Gln Val Leu Arg Glu
         595                 600                 605

 gcc cgc gag agc ctg ctg gag gac gtg cag gcc aac acc gtg ctg ggg     1872
 Ala Arg Glu Ser Leu Leu Glu Asp Val Gln Ala Asn Thr Val Leu Gly
     610                 615                 620

 gcc gag gtg gag gcc atc gtg aaa ggc gtc tgc aag ccc agc gag ttt     1920
 Ala Glu Val Glu Ala Ile Val Lys Gly Val Cys Lys Pro Ser Glu Phe
 625                 630                 635                 640

 gac aag ttc cgg atg ttc att gga gac ctg gac aaa gtg gtg aac ctc     1968
 Asp Lys Phe Arg Met Phe Ile Gly Asp Leu Asp Lys Val Val Asn Leu
                 645                 650                 655

 ctg ctg tcg ctg tca ggc cgc ctg gcc cgg gtg gag aat gcc ctc aat     2016
 Leu Leu Ser Leu Ser Gly Arg Leu Ala Arg Val Glu Asn Ala Leu Asn
             660                 665                 670

 aat ttg gac gac ggc gct tct ccc ggt gat cgg gtg agg gtg att tgg     2064
 Asn Leu Asp Asp Gly Ala Ser Pro Gly Asp Arg Val Arg Val Ile Trp
         675                 680                 685

 gcc acg cag aac gct gtc ctg gcg ctg ggc ttg gag acg gtg ccc ttc     2112
 Ala Thr Gln Asn Ala Val Leu Ala Leu Gly Leu Glu Thr Val Pro Phe
     690                 695                 700

 tgc act cag ccg agc ttg ttt gtc tgt caa cag caa tca ctg ctt gag     2160
 Cys Thr Gln Pro Ser Leu Phe Val Cys Gln Gln Gln Ser Leu Leu Glu
 705                 710                 715                 720

 aag cag aga gtc ctg atc cag cag cac gag gac gcc aag gag ctc aag     2208
 Lys Gln Arg Val Leu Ile Gln Gln His Glu Asp Ala Lys Glu Leu Lys
                 725                 730                 735

 gag aac ctg gac cgc cgc gag cgc atc gtc ttt gac att ttg gcc aac     2256
 Glu Asn Leu Asp Arg Arg Glu Arg Ile Val Phe Asp Ile Leu Ala Asn
             740                 745                 750

 tat ctg agc gag gag agc ctc gcg gac tat gag cac ttc gtg aag atg     2304
 Tyr Leu Ser Glu Glu Ser Leu Ala Asp Tyr Glu His Phe Val Lys Met
         755                 760                 765

 aag tcg gcc ctc atc atc gag cag cgg gag ctg gaa gat aaa atc cac     2352
 Lys Ser Ala Leu Ile Ile Glu Gln Arg Glu Leu Glu Asp Lys Ile His
     770                 775                 780

 ctt ggt gaa gag cag ctg aag tgc tta ttg gac agc ctt cag ccc gaa     2400
 Leu Gly Glu Glu Gln Leu Lys Cys Leu Leu Asp Ser Leu Gln Pro Glu
 785                 790                 795                 800

 agg ggc aaa taa                                                     2412
 Arg Gly Lys 






      <210> 666
      <211> 2421
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (1)..(2421)

      <400> 666
  atg tca ttt cta ctt tcc tca ctg ttg gct ctc tta act gtg tcc act      48
  Met Ser Phe Leu Leu Ser Ser Leu Leu Ala Leu Leu Thr Val Ser Thr
    1               5                  10                  15

 cct tca tgg tgt cag agc act gaa gca tct cca aaa cgt agt gat ggg       96
 Pro Ser Trp Cys Gln Ser Thr Glu Ala Ser Pro Lys Arg Ser Asp Gly
              20                  25                  30

 aca cca ttt cct tgg aat aaa ata cga ctt cct gag tac gtc atc cca      144
 Thr Pro Phe Pro Trp Asn Lys Ile Arg Leu Pro Glu Tyr Val Ile Pro
          35                  40                  45

 gtt cat tat gat ctc ttg atc cat gca aac ctt acc acg ctg acc ttc      192
 Val His Tyr Asp Leu Leu Ile His Ala Asn Leu Thr Thr Leu Thr Phe
      50                  55                  60

 tgg gga acc acg aaa gta gaa atc aca gcc agt cag ccc acc agc acc      240
 Trp Gly Thr Thr Lys Val Glu Ile Thr Ala Ser Gln Pro Thr Ser Thr
  65                  70                  75                  80

 atc atc ctg cat agt cac cac ctg cag ata tct agg gcc acc ctc agg      288
 Ile Ile Leu His Ser His His Leu Gln Ile Ser Arg Ala Thr Leu Arg
                  85                  90                  95

 aag gga gct gga gag agg cta tcg gaa gaa ccc ctg cag gtc ctg gaa      336
 Lys Gly Ala Gly Glu Arg Leu Ser Glu Glu Pro Leu Gln Val Leu Glu
             100                 105                 110

 cac ccc cgt cag gag caa att gca ctg ctg gct ccc gag ccc ctc ctt      384
 His Pro Arg Gln Glu Gln Ile Ala Leu Leu Ala Pro Glu Pro Leu Leu
         115                 120                 125

 gtc ggg ctc ccg tac aca gtt gtc att cac tat gct ggc aat ctt tcg      432
 Val Gly Leu Pro Tyr Thr Val Val Ile His Tyr Ala Gly Asn Leu Ser
     130                 135                 140

 gag act ttc cac gga ttt tac aaa agc acc tac aga acc aag gaa ggg      480
 Glu Thr Phe His Gly Phe Tyr Lys Ser Thr Tyr Arg Thr Lys Glu Gly
 145                 150                 155                 160

 gaa ctg agc tcg aca ttg cat tgc cag ata att ctc aaa cct gta ttt      528
 Glu Leu Ser Ser Thr Leu His Cys Gln Ile Ile Leu Lys Pro Val Phe
                 165                 170                 175

 aag gaa aag tgg atc agc cac atc ttg gca aaa ctc aca att tca gtt      576
 Lys Glu Lys Trp Ile Ser His Ile Leu Ala Lys Leu Thr Ile Ser Val
             180                 185                 190

 ttg ctt tgt ctc atc cgt gtt atc aat cca cat atg cca aat gtg gat      624
 Leu Leu Cys Leu Ile Arg Val Ile Asn Pro His Met Pro Asn Val Asp
         195                 200                 205

 tta cag tgt att gta aac ttt aaa atg gtg aaa tct gtg act gtt gct      672
 Leu Gln Cys Ile Val Asn Phe Lys Met Val Lys Ser Val Thr Val Ala
     210                 215                 220

 gaa gga ctc ata gaa gac cat ttt gat gtc act gtg aag atg agc acc      720
 Glu Gly Leu Ile Glu Asp His Phe Asp Val Thr Val Lys Met Ser Thr
 225                 230                 235                 240

 tat ctg gtg gcc ttc atc att tca gat ttt gag tct gtc agc aag ata      768
 Tyr Leu Val Ala Phe Ile Ile Ser Asp Phe Glu Ser Val Ser Lys Ile
                 245                 250                 255

 acc aag agt gga gtc aag gtt tct gtt tat gct gtg cca gac aag ata      816
 Thr Lys Ser Gly Val Lys Val Ser Val Tyr Ala Val Pro Asp Lys Ile
             260                 265                 270

 aat caa gca gat tat gca ctg gat gct gcg gtg act ctt cta gaa ttt      864
 Asn Gln Ala Asp Tyr Ala Leu Asp Ala Ala Val Thr Leu Leu Glu Phe
         275                 280                 285

 tat gag gat tat ttc agc ata ccg tat ccc cta ccc aaa caa gat ctt      912
 Tyr Glu Asp Tyr Phe Ser Ile Pro Tyr Pro Leu Pro Lys Gln Asp Leu
     290                 295                 300

 gct gct att ccc gac ttt cag tct ggt gct atg gaa aac tgg gga ctg      960
 Ala Ala Ile Pro Asp Phe Gln Ser Gly Ala Met Glu Asn Trp Gly Leu
 305                 310                 315                 320

 aca aca tat aga gaa tct gct ctg ttg ttt gat gca gaa aag tct tct     1008
 Thr Thr Tyr Arg Glu Ser Ala Leu Leu Phe Asp Ala Glu Lys Ser Ser
                 325                 330                 335

 gca tca agt aag ctt ggc atc aca atg act gtg gcc cat gaa ctg gct     1056
 Ala Ser Ser Lys Leu Gly Ile Thr Met Thr Val Ala His Glu Leu Ala
             340                 345                 350

 cac cag gga gat tat ttc ttt ggc aaa tgt ttt gac gca atg gag gta     1104
 His Gln Gly Asp Tyr Phe Phe Gly Lys Cys Phe Asp Ala Met Glu Val
         355                 360                 365

 gat gct tta aat tcc tca cac cct gtg tct aca cct gtg gaa aat cct     1152
 Asp Ala Leu Asn Ser Ser His Pro Val Ser Thr Pro Val Glu Asn Pro
     370                 375                 380

 gct cag atc cgg gag atg ttt gat gat gtt tct tat gat aag gga gct     1200
 Ala Gln Ile Arg Glu Met Phe Asp Asp Val Ser Tyr Asp Lys Gly Ala
 385                 390                 395                 400

 tgt att ctg aat atg cta agg gag tat ctt agt gct gac gca ttt aaa     1248
 Cys Ile Leu Asn Met Leu Arg Glu Tyr Leu Ser Ala Asp Ala Phe Lys
                 405                 410                 415

 agt ggt att gta cag tat ctc cag aag cat agc tat aaa aat aca aaa     1296
 Ser Gly Ile Val Gln Tyr Leu Gln Lys His Ser Tyr Lys Asn Thr Lys
             420                 425                 430

 aac gag gac ctg tgg gat agt aac atc tgc ctt gta gga tgg aac ctt     1344
 Asn Glu Asp Leu Trp Asp Ser Asn Ile Cys Leu Val Gly Trp Asn Leu
         435                 440                 445

 gct ttt gaa ata atg ccc tta cca cta ttg cta aaa tat ttc agc tgc     1392
 Ala Phe Glu Ile Met Pro Leu Pro Leu Leu Leu Lys Tyr Phe Ser Cys
     450                 455                 460

 atc tgt gta tcc tat gaa gtt gac tta tac tcc ctg ccc cca tct tcc     1440
 Ile Cys Val Ser Tyr Glu Val Asp Leu Tyr Ser Leu Pro Pro Ser Ser
 465                 470                 475                 480

 cag tac ctg tgg cat gtt cca ttg aca ttc atc acc agc aaa tcc gac     1488
 Gln Tyr Leu Trp His Val Pro Leu Thr Phe Ile Thr Ser Lys Ser Asp
                 485                 490                 495

 atg gtc cat cga ttt ttg cta aaa aca aaa aca gat gtg ctc atc ctc     1536
 Met Val His Arg Phe Leu Leu Lys Thr Lys Thr Asp Val Leu Ile Leu
             500                 505                 510

 cca gaa gag gtg gaa tgg atc aaa ttt aat gtg ggc atg aat ggc tat     1584
 Pro Glu Glu Val Glu Trp Ile Lys Phe Asn Val Gly Met Asn Gly Tyr
         515                 520                 525

 tac att gtg cat tac gag gat gat gga tgg gac tct ttg act ggc ctt     1632
 Tyr Ile Val His Tyr Glu Asp Asp Gly Trp Asp Ser Leu Thr Gly Leu
     530                 535                 540

 tta aaa gga aca cac aca gca gtc agc agt aat gat cgg gcg agt ctc     1680
 Leu Lys Gly Thr His Thr Ala Val Ser Ser Asn Asp Arg Ala Ser Leu
 545                 550                 555                 560

 att aac aat gca ttt cag ctc gtc agc att ggg aag ctg tcc att gaa     1728
 Ile Asn Asn Ala Phe Gln Leu Val Ser Ile Gly Lys Leu Ser Ile Glu
                 565                 570                 575

 aag gcc ttg gat tta tcc ctg tac ttg aaa cat gaa act gaa att atg     1776
 Lys Ala Leu Asp Leu Ser Leu Tyr Leu Lys His Glu Thr Glu Ile Met
             580                 585                 590

 ccc gtg ttt caa ggt ttg aat gag ctg att cct atg tat aag tta atg     1824
 Pro Val Phe Gln Gly Leu Asn Glu Leu Ile Pro Met Tyr Lys Leu Met
         595                 600                 605

 gag aaa aga gat atg aat gaa gtg gaa act caa ttc aag gcc ttc ctc     1872
 Glu Lys Arg Asp Met Asn Glu Val Glu Thr Gln Phe Lys Ala Phe Leu
     610                 615                 620

 atc agg ctg cta agg gac ctc att gat aag cag aca tgg aca gac gag     1920
 Ile Arg Leu Leu Arg Asp Leu Ile Asp Lys Gln Thr Trp Thr Asp Glu
 625                 630                 635                 640

 ggc tca gtc tca gag cga atg ctg cgg agt caa cta cta ctc ctc gcc     1968
 Gly Ser Val Ser Glu Arg Met Leu Arg Ser Gln Leu Leu Leu Leu Ala
                 645                 650                 655

 tgt gtg cac aac tat cag ccg tgc gta cag agg gca gaa ggc tat ttc     2016
 Cys Val His Asn Tyr Gln Pro Cys Val Gln Arg Ala Glu Gly Tyr Phe
             660                 665                 670

 aga aag tgg aag gaa tcc aat gga aac ttg agc ctg cct gtc gac gtg     2064
 Arg Lys Trp Lys Glu Ser Asn Gly Asn Leu Ser Leu Pro Val Asp Val
         675                 680                 685

 acc ttg gca gtg ttt gct gtg ggg gcc cag agc aca gaa ggc tgg gat     2112
 Thr Leu Ala Val Phe Ala Val Gly Ala Gln Ser Thr Glu Gly Trp Asp
     690                 695                 700

 ttt ctt tat agt aaa tat cag ttt tct ttg tcc agt act gag aaa agc     2160
 Phe Leu Tyr Ser Lys Tyr Gln Phe Ser Leu Ser Ser Thr Glu Lys Ser
 705                 710                 715                 720

 caa att gaa ttt gcc ctc tgc aga acc caa aat aag gaa aag ctt caa     2208
 Gln Ile Glu Phe Ala Leu Cys Arg Thr Gln Asn Lys Glu Lys Leu Gln
                 725                 730                 735

 tgg ttt gaa ctt ggc tca tct tcc ata gcc cac atg gta atg ggt aca     2256
 Trp Phe Glu Leu Gly Ser Ser Ser Ile Ala His Met Val Met Gly Thr
             740                 745                 750

 aca aat caa ttc tcc aca aga aca cgg ctt gaa gag aca att gaa acc     2304
 Thr Asn Gln Phe Ser Thr Arg Thr Arg Leu Glu Glu Thr Ile Glu Thr
         755                 760                 765

 att gaa gaa aac atc ggt tgg atg gat aag aat ttt gat aaa atc aga     2352
 Ile Glu Glu Asn Ile Gly Trp Met Asp Lys Asn Phe Asp Lys Ile Arg
     770                 775                 780

 gtg tgg ctg caa agt gaa aag ctt gaa cgt gct ttg gag ctg gaa gca     2400
 Val Trp Leu Gln Ser Glu Lys Leu Glu Arg Ala Leu Glu Leu Glu Ala
 785                 790                 795                 800

 gcc ttc ttg cac tta tcc taa                                         2421
 Ala Phe Leu His Leu Ser 
                 805





      <210> 667
      <211> 2058
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (1)..(2058)

      <400> 667
  atg aaa ata cta gac tgg cct agc ctc cca gtc tac atc ttt ctt ccg      48
  Met Lys Ile Leu Asp Trp Pro Ser Leu Pro Val Tyr Ile Phe Leu Pro
    1               5                  10                  15

 tgg tgg atg ctt cct gcc ctc gaa cat ctg act cca agt tct tca att       96
 Trp Trp Met Leu Pro Ala Leu Glu His Leu Thr Pro Ser Ser Ser Ile
              20                  25                  30

 ttg gga ctg gaa ctg gct atc ctt gct cct cag ctt gca gat agc cta      144
 Leu Gly Leu Glu Leu Ala Ile Leu Ala Pro Gln Leu Ala Asp Ser Leu
          35                  40                  45

 ttg cgg gac ctt gtg atc ata gaa gga aac ttc ctg tgt gaa gag gag      192
 Leu Arg Asp Leu Val Ile Ile Glu Gly Asn Phe Leu Cys Glu Glu Glu
      50                  55                  60

 atc ttg gaa agt ctc agg gtt aaa aag gct gct tta aat gtg ctg gtt      240
 Ile Leu Glu Ser Leu Arg Val Lys Lys Ala Ala Leu Asn Val Leu Val
  65                  70                  75                  80

 gat ttg ctc cct ggt tgt gta tac aca gta gca gct gat ctg tat ttg      288
 Asp Leu Leu Pro Gly Cys Val Tyr Thr Val Ala Ala Asp Leu Tyr Leu
                  85                  90                  95

 cag ccc tgc aga aag gaa cct tta ctg aaa acc aat ggc atc aca ttt      336
 Gln Pro Cys Arg Lys Glu Pro Leu Leu Lys Thr Asn Gly Ile Thr Phe
             100                 105                 110

 cag cag agc tgg tgc caa gtg ctg gag agc aga gca acc ttt gac aac      384
 Gln Gln Ser Trp Cys Gln Val Leu Glu Ser Arg Ala Thr Phe Asp Asn
         115                 120                 125

 ttc aca caa ttc acc cca gca gac tca cca cag gtc aga aag gaa tgt      432
 Phe Thr Gln Phe Thr Pro Ala Asp Ser Pro Gln Val Arg Lys Glu Cys
     130                 135                 140

 gga aag tat ctc ccc acc agg ttt cat ctc agg tat gtt agc gca gtc      480
 Gly Lys Tyr Leu Pro Thr Arg Phe His Leu Arg Tyr Val Ser Ala Val
 145                 150                 155                 160

 cct ggg aaa cca cac act gtt act ggc tgg att ctg aca aca gtg gtg      528
 Pro Gly Lys Pro His Thr Val Thr Gly Trp Ile Leu Thr Thr Val Val
                 165                 170                 175

 aca ttc agt gcc aac tgc tcc ctt ttg acc gtc acc agt ccc cgc ctg      576
 Thr Phe Ser Ala Asn Cys Ser Leu Leu Thr Val Thr Ser Pro Arg Leu
             180                 185                 190

 ggc aaa ata aat ttg aaa aac gtg ggg gga ggg gaa gga aga gcc ccc      624
 Gly Lys Ile Asn Leu Lys Asn Val Gly Gly Gly Glu Gly Arg Ala Pro
         195                 200                 205

 tca gcc cga atg ctg ggg ttt cca ttc cta cgg cta ggg atc cca aac      672
 Ser Ala Arg Met Leu Gly Phe Pro Phe Leu Arg Leu Gly Ile Pro Asn
     210                 215                 220

 cta ccc aac cca cct ccc aac cct gaa aaa cca ttt tcc ctt cta ccc      720
 Leu Pro Asn Pro Pro Pro Asn Pro Glu Lys Pro Phe Ser Leu Leu Pro
 225                 230                 235                 240

 acc ggg ccc agg cag aga atc ggc acc aag aca gcg agg agc atc cac      768
 Thr Gly Pro Arg Gln Arg Ile Gly Thr Lys Thr Ala Arg Ser Ile His
                 245                 250                 255

 cca ggg cca gac act cat gtt cgc ggc tcg cac ttg ctg act tgc atc      816
 Pro Gly Pro Asp Thr His Val Arg Gly Ser His Leu Leu Thr Cys Ile
             260                 265                 270

 tct cag ttg cat tcc cgc tat gtg gac ctg cca gtt gct gaa cca gca      864
 Ser Gln Leu His Ser Arg Tyr Val Asp Leu Pro Val Ala Glu Pro Ala
         275                 280                 285

 gag gaa act cag cgt cat gga aag aac act aaa ctt aga aca gtt gag      912
 Glu Glu Thr Gln Arg His Gly Lys Asn Thr Lys Leu Arg Thr Val Glu
     290                 295                 300

 tgt gag tct cat ttc tgc ctc tta ctg ctt ttg cga ccc tgg gca agt      960
 Cys Glu Ser His Phe Cys Leu Leu Leu Leu Leu Arg Pro Trp Ala Ser
 305                 310                 315                 320

 cat tca act tcc cag aac ctg gat ttc ctc tta gta act gcc cta tca     1008
 His Ser Thr Ser Gln Asn Leu Asp Phe Leu Leu Val Thr Ala Leu Ser
                 325                 330                 335

 tcc tcc aac aat cct cag gga agc ctt aag aag ctt aca atc atg gtg     1056
 Ser Ser Asn Asn Pro Gln Gly Ser Leu Lys Lys Leu Thr Ile Met Val
             340                 345                 350

 gaa ggc aaa ggg gga gca ggc aca tca tat ggt gaa aac agg aac agg     1104
 Glu Gly Lys Gly Gly Ala Gly Thr Ser Tyr Gly Glu Asn Arg Asn Arg
         355                 360                 365

 caa gag aga atg gag gat gag ggc ggt tct gag att ttg att aag aga     1152
 Gln Glu Arg Met Glu Asp Glu Gly Gly Ser Glu Ile Leu Ile Lys Arg
     370                 375                 380

 gat ctg tcc ccg cac cgc aga ggg atg gtg cca aat ggc cag gct tcc     1200
 Asp Leu Ser Pro His Arg Arg Gly Met Val Pro Asn Gly Gln Ala Ser
 385                 390                 395                 400

 tgg gca ctg cgt cct cat tcc cag aaa cca ggg tca ata gga cga tca     1248
 Trp Ala Leu Arg Pro His Ser Gln Lys Pro Gly Ser Ile Gly Arg Ser
                 405                 410                 415

 gca cgg atg ggt gtg ggg att gag gaa att gga gat att gca gct gac     1296
 Ala Arg Met Gly Val Gly Ile Glu Glu Ile Gly Asp Ile Ala Ala Asp
             420                 425                 430

 gcc agg tac cgg gag agg aga gtc cgc aga tgc agg gac gtt gct ctg     1344
 Ala Arg Tyr Arg Glu Arg Arg Val Arg Arg Cys Arg Asp Val Ala Leu
         435                 440                 445

 ctc ctc ttt gga cgt tct ctg cct cag tgt cag gcc tgc gaa atg gga     1392
 Leu Leu Phe Gly Arg Ser Leu Pro Gln Cys Gln Ala Cys Glu Met Gly
     450                 455                 460

 gtc aag ccc gtc ccc ccc cgc gaa gac cgc gcc tgg ggc tcg aga gct     1440
 Val Lys Pro Val Pro Pro Arg Glu Asp Arg Ala Trp Gly Ser Arg Ala
 465                 470                 475                 480

 gac gga ctg ccc ttt cca ggc tgc ccc aag ggc ctg gga ggc tgc ggt     1488
 Asp Gly Leu Pro Phe Pro Gly Cys Pro Lys Gly Leu Gly Gly Cys Gly
                 485                 490                 495

 acc gcc tgt cgg tcc cgg tcc cga gcg cgc ttg ctt aag agt tct caa     1536
 Thr Ala Cys Arg Ser Arg Ser Arg Ala Arg Leu Leu Lys Ser Ser Gln
             500                 505                 510

 aga cgg ggt tgg aag cag tac aga cgt ccc cgg tta tcg ctg ccg ggc     1584
 Arg Arg Gly Trp Lys Gln Tyr Arg Arg Pro Arg Leu Ser Leu Pro Gly
         515                 520                 525

 tta gtc cag gct ttg aaa ctg cag caa ctc cgc aaa gaa agc ctt tgg     1632
 Leu Val Gln Ala Leu Lys Leu Gln Gln Leu Arg Lys Glu Ser Leu Trp
     530                 535                 540

 gaa aac ctc cta gag ggc cga atg tgg agg tcg gcc cct tgg gga gac     1680
 Glu Asn Leu Leu Glu Gly Arg Met Trp Arg Ser Ala Pro Trp Gly Asp
 545                 550                 555                 560

 gag gag ggc gag gcg ctg gca gga gga ccg gcc aag ccg ctg tcc tcg     1728
 Glu Glu Gly Glu Ala Leu Ala Gly Gly Pro Ala Lys Pro Leu Ser Ser
                 565                 570                 575

 gat gga gag gag agg gag agg cac gag gcc acc tca ttc gtc cct ttc     1776
 Asp Gly Glu Glu Arg Glu Arg His Glu Ala Thr Ser Phe Val Pro Phe
             580                 585                 590

 cgc ttc ggg ctg ggg aga cag gac acc gag ggt ttc ttt ctg tct ctg     1824
 Arg Phe Gly Leu Gly Arg Gln Asp Thr Glu Gly Phe Phe Leu Ser Leu
         595                 600                 605

 cca agc ctc acg ctt ctt tca aat gat ttt agc ctg gat cct ggt gga     1872
 Pro Ser Leu Thr Leu Leu Ser Asn Asp Phe Ser Leu Asp Pro Gly Gly
     610                 615                 620

 agg aga gaa cga gcc act gat tgc ctt ttg cgg ttc tgc tct tcc tcc     1920
 Arg Arg Glu Arg Ala Thr Asp Cys Leu Leu Arg Phe Cys Ser Ser Ser
 625                 630                 635                 640

 ttc caa cct cct cgc ctt tgc cgg agg ctc tcc gag gct aag cca caa     1968
 Phe Gln Pro Pro Arg Leu Cys Arg Arg Leu Ser Glu Ala Lys Pro Gln
                 645                 650                 655

 act cta ggg ctc cgg gtc cca gaa aaa gga ata ctt gtg ttc ccc cct     2016
 Thr Leu Gly Leu Arg Val Pro Glu Lys Gly Ile Leu Val Phe Pro Pro
             660                 665                 670

 ccc cca ccc ctt cgc cgt atc cct gct tgg agc acg ctg tag             2058
 Pro Pro Pro Leu Arg Arg Ile Pro Ala Trp Ser Thr Leu 
         675                 680                 685





      <210> 668
      <211> 2823
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (1)..(2823)

      <400> 668
  atg gtt gca tgc tat ttg gat gtt ctc aca aca tgg cag ctg gct ttc      48
  Met Val Ala Cys Tyr Leu Asp Val Leu Thr Thr Trp Gln Leu Ala Phe
    1               5                  10                  15

 ctg agg gca ttg agc tgt gac tgt gcc gag cag gca gaa gct gag ctc       96
 Leu Arg Ala Leu Ser Cys Asp Cys Ala Glu Gln Ala Glu Ala Glu Leu
              20                  25                  30

 tgg ata gag ctg ctc aat gct tgt tgt ctg gcc aat cag aca aca gag      144
 Trp Ile Glu Leu Leu Asn Ala Cys Cys Leu Ala Asn Gln Thr Thr Glu
          35                  40                  45

 tgg caa aaa acc aaa gcc ttc aaa atg gcc tat gtt atg gac aga att      192
 Trp Gln Lys Thr Lys Ala Phe Lys Met Ala Tyr Val Met Asp Arg Ile
      50                  55                  60

 ttg tcc tcc cca aat tta tgt gtt gaa gtc cta act ccc cac aca cct      240
 Leu Ser Ser Pro Asn Leu Cys Val Glu Val Leu Thr Pro His Thr Pro
  65                  70                  75                  80

 cag aat gtg gct gta ttt gga gat tgg act ttt aaa gag tgt ttt gaa      288
 Gln Asn Val Ala Val Phe Gly Asp Trp Thr Phe Lys Glu Cys Phe Glu
                  85                  90                  95

 att tgt gat gga aaa tta aaa tgg aag gaa aat aag tat ata gaa gat      336
 Ile Cys Asp Gly Lys Leu Lys Trp Lys Glu Asn Lys Tyr Ile Glu Asp
             100                 105                 110

 gag aag aga ata atg gaa agg aaa aag agt gag gaa aag att aag act      384
 Glu Lys Arg Ile Met Glu Arg Lys Lys Ser Glu Glu Lys Ile Lys Thr
         115                 120                 125

 cag ttg gcg ctt cag cag ctg aat gcc gtt gcc tca cat ggt tca aca      432
 Gln Leu Ala Leu Gln Gln Leu Asn Ala Val Ala Ser His Gly Ser Thr
     130                 135                 140

 cca cct tat act tta tta aat cag gct ttc ttg aaa ata gcc atg tcg      480
 Pro Pro Tyr Thr Leu Leu Asn Gln Ala Phe Leu Lys Ile Ala Met Ser
 145                 150                 155                 160

 aga ccc agg ttt aat cct cga gga gac ttt cca ctt caa agg cca cga      528
 Arg Pro Arg Phe Asn Pro Arg Gly Asp Phe Pro Leu Gln Arg Pro Arg
                 165                 170                 175

 gca cct aac cct tct ggg atg agg cct cca gga cca ttt atg agg cct      576
 Ala Pro Asn Pro Ser Gly Met Arg Pro Pro Gly Pro Phe Met Arg Pro
             180                 185                 190

 gga tct atg ggt ctc cca aga ttt tac cca gca ggg aga gca cgt gga      624
 Gly Ser Met Gly Leu Pro Arg Phe Tyr Pro Ala Gly Arg Ala Arg Gly
         195                 200                 205

 att cca cac aga ttt gct ggc cat gaa tct tat cag aac atg ggg cca      672
 Ile Pro His Arg Phe Ala Gly His Glu Ser Tyr Gln Asn Met Gly Pro
     210                 215                 220

 cag aga atg aat gtt cag gta act caa cac aga act gat cca aga ttg      720
 Gln Arg Met Asn Val Gln Val Thr Gln His Arg Thr Asp Pro Arg Leu
 225                 230                 235                 240

 acc aaa gaa aaa ctg gat ttt cat gaa gca caa cag aag aag ggg aag      768
 Thr Lys Glu Lys Leu Asp Phe His Glu Ala Gln Gln Lys Lys Gly Lys
                 245                 250                 255

 cct cat ggt agc cgg tgg gat gat gag cct cat ata tct gca tca gtg      816
 Pro His Gly Ser Arg Trp Asp Asp Glu Pro His Ile Ser Ala Ser Val
             260                 265                 270

 gca gtg aaa cag agt tct gta aca cag gtt aca gag cag agt ccc aaa      864
 Ala Val Lys Gln Ser Ser Val Thr Gln Val Thr Glu Gln Ser Pro Lys
         275                 280                 285

 gta cag agc cgc tat aca aaa gag agt gcc tca agt atc tta gca agt      912
 Val Gln Ser Arg Tyr Thr Lys Glu Ser Ala Ser Ser Ile Leu Ala Ser
     290                 295                 300

 ttt gga tta tct aat gaa gac cta gaa gaa ctt agt cgc tat cct gat      960
 Phe Gly Leu Ser Asn Glu Asp Leu Glu Glu Leu Ser Arg Tyr Pro Asp
 305                 310                 315                 320

 gaa caa cta act cct gaa aat atg cca tta att ttg agg gat ata aga     1008
 Glu Gln Leu Thr Pro Glu Asn Met Pro Leu Ile Leu Arg Asp Ile Arg
                 325                 330                 335

 atg cga aaa atg ggg cgc cga tta cct aat tta cct tct cag agc aga     1056
 Met Arg Lys Met Gly Arg Arg Leu Pro Asn Leu Pro Ser Gln Ser Arg
             340                 345                 350

 aat aaa gaa aca ctt ggt agt gaa gca gtt tca agt aat gtg atc gat     1104
 Asn Lys Glu Thr Leu Gly Ser Glu Ala Val Ser Ser Asn Val Ile Asp
         355                 360                 365

 tat ggg cat gca agc aaa tat ggc tac aca gaa gat cca ctt gaa gta     1152
 Tyr Gly His Ala Ser Lys Tyr Gly Tyr Thr Glu Asp Pro Leu Glu Val
     370                 375                 380

 cgt att tat gat cct gaa att cca act gat gag gtc gag aat gaa ttt     1200
 Arg Ile Tyr Asp Pro Glu Ile Pro Thr Asp Glu Val Glu Asn Glu Phe
 385                 390                 395                 400

 cag tca cag cag aac att tct gca tct gtt ccc aat cca aat gtg ata     1248
 Gln Ser Gln Gln Asn Ile Ser Ala Ser Val Pro Asn Pro Asn Val Ile
                 405                 410                 415

 tgt aat tct atg ttt cct gtt gaa gac gta ttt cgc caa atg gac ttc     1296
 Cys Asn Ser Met Phe Pro Val Glu Asp Val Phe Arg Gln Met Asp Phe
             420                 425                 430

 ccc ggt gag tcc tcc aat aat cgg tcc ttt ttc tca gtt gag agt gga     1344
 Pro Gly Glu Ser Ser Asn Asn Arg Ser Phe Phe Ser Val Glu Ser Gly
         435                 440                 445

 acc aag atg tca ggc tta cac att tca gga gga cag tca gtc ctt gaa     1392
 Thr Lys Met Ser Gly Leu His Ile Ser Gly Gly Gln Ser Val Leu Glu
     450                 455                 460

 ccc ata aaa tcc gtc aac caa tcc att aac caa aca gtt agc cag aca     1440
 Pro Ile Lys Ser Val Asn Gln Ser Ile Asn Gln Thr Val Ser Gln Thr
 465                 470                 475                 480

 atg agt caa tct ctg att cct cca tct atg aac cag caa cct ttt tcg     1488
 Met Ser Gln Ser Leu Ile Pro Pro Ser Met Asn Gln Gln Pro Phe Ser
                 485                 490                 495

 tcg gaa tta att tca tct gta agc cag caa gag cgg atc cca cat gaa     1536
 Ser Glu Leu Ile Ser Ser Val Ser Gln Gln Glu Arg Ile Pro His Glu
             500                 505                 510

 cct gtg att aat tca tct aac gta cat gtt gga tca aga gga agt aaa     1584
 Pro Val Ile Asn Ser Ser Asn Val His Val Gly Ser Arg Gly Ser Lys
         515                 520                 525

 aag aat tac cag tca cag gct gac att ccc att cgg tct ccc ttt ggt     1632
 Lys Asn Tyr Gln Ser Gln Ala Asp Ile Pro Ile Arg Ser Pro Phe Gly
     530                 535                 540

 att gtg aaa gca tcc tgg cta cca aag ttt tca cat gct gat gcc cag     1680
 Ile Val Lys Ala Ser Trp Leu Pro Lys Phe Ser His Ala Asp Ala Gln
 545                 550                 555                 560

 aag atg aag aga ctt cca act cct tct atg atg aat gat tat tat gca     1728
 Lys Met Lys Arg Leu Pro Thr Pro Ser Met Met Asn Asp Tyr Tyr Ala
                 565                 570                 575

 gca tct cca aga ata ttt cca cat ttg tgt tct ctg tgt aac gta gaa     1776
 Ala Ser Pro Arg Ile Phe Pro His Leu Cys Ser Leu Cys Asn Val Glu
             580                 585                 590

 tgt agt cat ttg aag gat tgg att cag cat caa aat aca tct act cat     1824
 Cys Ser His Leu Lys Asp Trp Ile Gln His Gln Asn Thr Ser Thr His
         595                 600                 605

 att gag agc tgt cga cag tta cgt caa caa aat gag ggc aat aga aaa     1872
 Ile Glu Ser Cys Arg Gln Leu Arg Gln Gln Asn Glu Gly Asn Arg Lys
     610                 615                 620

 gaa aat gaa act cca cga aga cgt tct cat tcc ccc agt cct agg cgt     1920
 Glu Asn Glu Thr Pro Arg Arg Arg Ser His Ser Pro Ser Pro Arg Arg
 625                 630                 635                 640

 tct aga aga tca agc tca agt cac aga ttc cgt cgg tct cga agc cca     1968
 Ser Arg Arg Ser Ser Ser Ser His Arg Phe Arg Arg Ser Arg Ser Pro
                 645                 650                 655

 atg cat tac atg tat agg ccg aga agt cga agt cca aga att tgc cat     2016
 Met His Tyr Met Tyr Arg Pro Arg Ser Arg Ser Pro Arg Ile Cys His
             660                 665                 670

 cgt ttc att tct aga tac aga tcc aga tcc aga tcc cgt tca cca tat     2064
 Arg Phe Ile Ser Arg Tyr Arg Ser Arg Ser Arg Ser Arg Ser Pro Tyr
         675                 680                 685

 cga att aga aat cca ttt aga ggt agt cca aaa tgc ttt cga tca gtt     2112
 Arg Ile Arg Asn Pro Phe Arg Gly Ser Pro Lys Cys Phe Arg Ser Val
     690                 695                 700

 agc cct gag agg atg tca agg aga tca gtg aga tca tca gat aga aaa     2160
 Ser Pro Glu Arg Met Ser Arg Arg Ser Val Arg Ser Ser Asp Arg Lys
 705                 710                 715                 720

 aaa gca tta gaa gat gta gta caa cga tct ggg cat ggg aca gaa ttt     2208
 Lys Ala Leu Glu Asp Val Val Gln Arg Ser Gly His Gly Thr Glu Phe
                 725                 730                 735

 aat aaa cag aag cat ctt gaa gct gct gat aag gga cat tca cca gca     2256
 Asn Lys Gln Lys His Leu Glu Ala Ala Asp Lys Gly His Ser Pro Ala
             740                 745                 750

 caa aag cct aaa act agc agt gga aca aaa cca tca gtt aaa cct aca     2304
 Gln Lys Pro Lys Thr Ser Ser Gly Thr Lys Pro Ser Val Lys Pro Thr
         755                 760                 765

 agc gct aca aag agt gat tca aat cta gga gga cat tct att cgt tgt     2352
 Ser Ala Thr Lys Ser Asp Ser Asn Leu Gly Gly His Ser Ile Arg Cys
     770                 775                 780

 aaa tca aag aat ctt gaa gat gac act ttg tca gaa tgt aaa cag gtg     2400
 Lys Ser Lys Asn Leu Glu Asp Asp Thr Leu Ser Glu Cys Lys Gln Val
 785                 790                 795                 800

 tct gat aaa gct gtt tct ctc cag cga aag ctt cgg aaa gaa cag tca     2448
 Ser Asp Lys Ala Val Ser Leu Gln Arg Lys Leu Arg Lys Glu Gln Ser
                 805                 810                 815

 ttg cat tat ggt tcg gtt ctt ctt ata act gaa tta cca gag gat ggt     2496
 Leu His Tyr Gly Ser Val Leu Leu Ile Thr Glu Leu Pro Glu Asp Gly
             820                 825                 830

 tgt act gaa gaa gat gtg aga aaa tta ttt caa cca ttt ggg aaa gtg     2544
 Cys Thr Glu Glu Asp Val Arg Lys Leu Phe Gln Pro Phe Gly Lys Val
         835                 840                 845

 aat gat gtc cta att gtt cca tat aga aaa gag gct tac cta gaa atg     2592
 Asn Asp Val Leu Ile Val Pro Tyr Arg Lys Glu Ala Tyr Leu Glu Met
     850                 855                 860

 gaa ttt aaa gag gca att act gca att atg aag tac att gaa aca aca     2640
 Glu Phe Lys Glu Ala Ile Thr Ala Ile Met Lys Tyr Ile Glu Thr Thr
 865                 870                 875                 880

 cct ctt acg ata aaa gga aaa agt gtg aaa ata tgt gtt cca gga aag     2688
 Pro Leu Thr Ile Lys Gly Lys Ser Val Lys Ile Cys Val Pro Gly Lys
                 885                 890                 895

 aaa aaa gca cag aac aaa gag gtg aag aaa aag act tta gag tca aag     2736
 Lys Lys Ala Gln Asn Lys Glu Val Lys Lys Lys Thr Leu Glu Ser Lys
             900                 905                 910

 aaa gta tct gca tct acc tta aaa aga gat gca gat gct tca aaa gct     2784
 Lys Val Ser Ala Ser Thr Leu Lys Arg Asp Ala Asp Ala Ser Lys Ala
         915                 920                 925

 gtt gaa att gtt act tca act tct gct gtt ccc agc tga                 2823
 Val Glu Ile Val Thr Ser Thr Ser Ala Val Pro Ser 
     930                 935                 940





      <210> 669
      <211> 1722
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (1)..(1722)

      <400> 669
  atg gcc tcg cag gcc agg tcg tcc ttg gtg gaa gga acc atg aac tgg      48
  Met Ala Ser Gln Ala Arg Ser Ser Leu Val Glu Gly Thr Met Asn Trp
    1               5                  10                  15

 cat ctc ccc ctc ttc ctc ttg gcc tct gtg acg ctg cct tcc atc tgc       96
 His Leu Pro Leu Phe Leu Leu Ala Ser Val Thr Leu Pro Ser Ile Cys
              20                  25                  30

 tcc cac ttc aat cct ctg tct ctc gag gaa cta ggc tcc aac acg ggg      144
 Ser His Phe Asn Pro Leu Ser Leu Glu Glu Leu Gly Ser Asn Thr Gly
          35                  40                  45

 atc cag gtt ttc aat cag att gtg aag tcg agg cct cat gac aac atc      192
 Ile Gln Val Phe Asn Gln Ile Val Lys Ser Arg Pro His Asp Asn Ile
      50                  55                  60

 gtg atc tct ccc cat ggg att gcg tcg gtc ctg ggg atg ctt cag ctg      240
 Val Ile Ser Pro His Gly Ile Ala Ser Val Leu Gly Met Leu Gln Leu
  65                  70                  75                  80

 ggg gcg gac ggc agg acc aag aag cag ctc gcc atg gtg atg aga tac      288
 Gly Ala Asp Gly Arg Thr Lys Lys Gln Leu Ala Met Val Met Arg Tyr
                  85                  90                  95

 ggc gta aat gga gtt ggt aaa ata tta aag aag atc aac aag gcc atc      336
 Gly Val Asn Gly Val Gly Lys Ile Leu Lys Lys Ile Asn Lys Ala Ile
             100                 105                 110

 gtc tcc aag aag aat aaa gac att gtg aca gtg gct aac gcc gtg ttt      384
 Val Ser Lys Lys Asn Lys Asp Ile Val Thr Val Ala Asn Ala Val Phe
         115                 120                 125

 gtt aag aat gcc tct gaa att gaa gtg cct ttt gtt aca agg aac aaa      432
 Val Lys Asn Ala Ser Glu Ile Glu Val Pro Phe Val Thr Arg Asn Lys
     130                 135                 140

 gat gtg ttc cag tgt gag gtc cgg aat gtg aac ttt gag gat cca gcc      480
 Asp Val Phe Gln Cys Glu Val Arg Asn Val Asn Phe Glu Asp Pro Ala
 145                 150                 155                 160

 tct gcc tgt gat tcc atc aat gca tgg gtt aaa aat gaa acc agg gat      528
 Ser Ala Cys Asp Ser Ile Asn Ala Trp Val Lys Asn Glu Thr Arg Asp
                 165                 170                 175

 atg att gac aat ctg ctg tcc cca gat ctt att gat ggt gtg ctc acc      576
 Met Ile Asp Asn Leu Leu Ser Pro Asp Leu Ile Asp Gly Val Leu Thr
             180                 185                 190

 aga ctg gtc ctc gtc aac gca gtg tat ttc aag ggt ctg tgg aaa tca      624
 Arg Leu Val Leu Val Asn Ala Val Tyr Phe Lys Gly Leu Trp Lys Ser
         195                 200                 205

 cgg ttc caa ccc gag aac aca aag aaa cgc act ttc gtg gca gcc gac      672
 Arg Phe Gln Pro Glu Asn Thr Lys Lys Arg Thr Phe Val Ala Ala Asp
     210                 215                 220

 ggg aaa tcc tat caa gtg cca atg ctg gcc cag ctc tcc gtg ttc cgg      720
 Gly Lys Ser Tyr Gln Val Pro Met Leu Ala Gln Leu Ser Val Phe Arg
 225                 230                 235                 240

 tgt gac tgt ccg tca ttt tct gcc tgt ttc ctc act ctg acc tgc agg      768
 Cys Asp Cys Pro Ser Phe Ser Ala Cys Phe Leu Thr Leu Thr Cys Arg
                 245                 250                 255

 agt ggc cca gct cga gct gct gtg tcc aaa ctc aca ggg ccc agg gct      816
 Ser Gly Pro Ala Arg Ala Ala Val Ser Lys Leu Thr Gly Pro Arg Ala
             260                 265                 270

 ttt aca gat aaa gaa act aag act tgg agt caa gga act tgc caa agt      864
 Phe Thr Asp Lys Glu Thr Lys Thr Trp Ser Gln Gly Thr Cys Gln Ser
         275                 280                 285

 ctc aga gct agt gtg cta caa gtg cag gat ttg aat aca ggt ctt ata      912
 Leu Arg Ala Ser Val Leu Gln Val Gln Asp Leu Asn Thr Gly Leu Ile
     290                 295                 300

 acc cca gat ctc gtg gct ttg gca cgt gtc ctc tat aaa agg atg cag      960
 Thr Pro Asp Leu Val Ala Leu Ala Arg Val Leu Tyr Lys Arg Met Gln
 305                 310                 315                 320

 tac ttg agt gac cag gta gaa aga cag aaa agg tgt tat ttt atc tcc     1008
 Tyr Leu Ser Asp Gln Val Glu Arg Gln Lys Arg Cys Tyr Phe Ile Ser
                 325                 330                 335

 cag ctc ctc aag gca cca aat aaa ggg tcg aca agt gcc ccc aat gat     1056
 Gln Leu Leu Lys Ala Pro Asn Lys Gly Ser Thr Ser Ala Pro Asn Asp
             340                 345                 350

 tta tgg tac aac ttc att gaa ctg ccc tac cac ggg gaa agc atc agc     1104
 Leu Trp Tyr Asn Phe Ile Glu Leu Pro Tyr His Gly Glu Ser Ile Ser
         355                 360                 365

 atg ctg att gca ctg ccg act gag agc tcc act ccg ctg tct gcc atc     1152
 Met Leu Ile Ala Leu Pro Thr Glu Ser Ser Thr Pro Leu Ser Ala Ile
     370                 375                 380

 atc cca cac atc agc acc aag acc ata gac agc tgg atg agc atc atg     1200
 Ile Pro His Ile Ser Thr Lys Thr Ile Asp Ser Trp Met Ser Ile Met
 385                 390                 395                 400

 gtg ccc aag agg gtg cag gtg atc ctg ccc aag ttc aca gct gta gca     1248
 Val Pro Lys Arg Val Gln Val Ile Leu Pro Lys Phe Thr Ala Val Ala
                 405                 410                 415

 caa aca gat ttg aag gag ccg ctg aaa gtt ctt ggc att act gac atg     1296
 Gln Thr Asp Leu Lys Glu Pro Leu Lys Val Leu Gly Ile Thr Asp Met
             420                 425                 430

 ttt gat tca tca aag gca aat ttt gca aaa ata aca agg tca gaa aac     1344
 Phe Asp Ser Ser Lys Ala Asn Phe Ala Lys Ile Thr Arg Ser Glu Asn
         435                 440                 445

 ctc cat gtt tct cat atc ttg caa aaa gca aaa att gaa gtc agt gaa     1392
 Leu His Val Ser His Ile Leu Gln Lys Ala Lys Ile Glu Val Ser Glu
     450                 455                 460

 gat gga acc aaa gct tca gca gca aca agc tta tta aat gga aac aag     1440
 Asp Gly Thr Lys Ala Ser Ala Ala Thr Ser Leu Leu Asn Gly Asn Lys
 465                 470                 475                 480

 cct ggc aga cga gga atg gcc aag acc cat gag gct aaa gaa gtt tgc     1488
 Pro Gly Arg Arg Gly Met Ala Lys Thr His Glu Ala Lys Glu Val Cys
                 485                 490                 495

 ttt cca agt cag atg cct aca cct gct gca att ctc att gca aga tca     1536
 Phe Pro Ser Gln Met Pro Thr Pro Ala Ala Ile Leu Ile Ala Arg Ser
             500                 505                 510

 tcg cct ccc tgg ttt ata gta gac aga cct ttt ctg ttt ttc atc cga     1584
 Ser Pro Pro Trp Phe Ile Val Asp Arg Pro Phe Leu Phe Phe Ile Arg
         515                 520                 525

 cat aat cct aca ggt cat gag atg ggt act tcc gat tct gcc ttg gtc     1632
 His Asn Pro Thr Gly His Glu Met Gly Thr Ser Asp Ser Ala Leu Val
     530                 535                 540

 act gtg gag gaa gag agt agg tac cga ccc aaa tac act gaa agc tct     1680
 Thr Val Glu Glu Glu Ser Arg Tyr Arg Pro Lys Tyr Thr Glu Ser Ser
 545                 550                 555                 560

 gac tta gct ggc ctt tca ctc tgt cct aaa aag gag agg tga             1722
 Asp Leu Ala Gly Leu Ser Leu Cys Pro Lys Lys Glu Arg 
                 565                 570





      <210> 670
      <211> 603
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (1)..(603)

      <400> 670
  atg ctg ctg ccc ctt tgg ttt ttc ctg gtc ctt gtg caa ctg tac gcg      48
  Met Leu Leu Pro Leu Trp Phe Phe Leu Val Leu Val Gln Leu Tyr Ala
    1               5                  10                  15

 gac tgg ctc tct ggc tcc cct gca gac cca gcc ctc att ctt cct cct       96
 Asp Trp Leu Ser Gly Ser Pro Ala Asp Pro Ala Leu Ile Leu Pro Pro
              20                  25                  30

 atc tcc ttc aac aca ctt aca cag gca cag aca tgg gac agc tct agc      144
 Ile Ser Phe Asn Thr Leu Thr Gln Ala Gln Thr Trp Asp Ser Ser Ser
          35                  40                  45

 tac agt gtt cca tct gaa gga gac agt gac aat gtg ttt cta aga cct      192
 Tyr Ser Val Pro Ser Glu Gly Asp Ser Asp Asn Val Phe Leu Arg Pro
      50                  55                  60

 cag aga aat ttg gaa tct ata gac ccg cag ttt aca atc cgg agg aaa      240
 Gln Arg Asn Leu Glu Ser Ile Asp Pro Gln Phe Thr Ile Arg Arg Lys
  65                  70                  75                  80

 atg gag cag atg aga gaa gag aaa gag ctg gtg gaa caa ctt cgt gag      288
 Met Glu Gln Met Arg Glu Glu Lys Glu Leu Val Glu Gln Leu Arg Glu
                  85                  90                  95

 agc att gag atg aga ttg aag gtc agt cta cac gaa gac ctg ggg gca      336
 Ser Ile Glu Met Arg Leu Lys Val Ser Leu His Glu Asp Leu Gly Ala
             100                 105                 110

 gcc ctc atg gat ggt gtc gtc ctc tgc cat ctg gtc aac cac atc cgc      384
 Ala Leu Met Asp Gly Val Val Leu Cys His Leu Val Asn His Ile Arg
         115                 120                 125

 cca cgg tcg gtt gca agc atc cat gtc cca tca cca gcg gtt atc ctc      432
 Pro Arg Ser Val Ala Ser Ile His Val Pro Ser Pro Ala Val Ile Leu
     130                 135                 140

 atc tct gct gta gag gag ata gag cct gca ctc agg gct ctc ttc cta      480
 Ile Ser Ala Val Glu Glu Ile Glu Pro Ala Leu Arg Ala Leu Phe Leu
 145                 150                 155                 160

 ggt atc aca gca tgt tgt gaa cta gaa gag agc caa aga gtc agt ttt      528
 Gly Ile Thr Ala Cys Cys Glu Leu Glu Glu Ser Gln Arg Val Ser Phe
                 165                 170                 175

 atg gtt gtt cag atg aaa gtg gag gaa tca cag ata aac ttg tcc ttg      576
 Met Val Val Gln Met Lys Val Glu Glu Ser Gln Ile Asn Leu Ser Leu
             180                 185                 190

 aaa cct aca cag gat tta tac aaa tag                                  603
 Lys Pro Thr Gln Asp Leu Tyr Lys 
         195                 200





      <210> 671
      <211> 2220
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (1)..(2220)

      <400> 671
  atg agg ctt ctc gtg gcc cca ctc ttg cta gct tgg gtg gct ggt gcc      48
  Met Arg Leu Leu Val Ala Pro Leu Leu Leu Ala Trp Val Ala Gly Ala
    1               5                  10                  15

 act gcc gct gtg ccc gtg gta ccc tgg cat gtt ccc tgc ccc cct cag       96
 Thr Ala Ala Val Pro Val Val Pro Trp His Val Pro Cys Pro Pro Gln
              20                  25                  30

 tgt gcc tgc cag atc cgg ccc tgg tat acg ccc cgc tcg tcc tac cgc      144
 Cys Ala Cys Gln Ile Arg Pro Trp Tyr Thr Pro Arg Ser Ser Tyr Arg
          35                  40                  45

 gag gct acc act gtg gac tgc aat gac cta ttc ctg acg gca gtc ccc      192
 Glu Ala Thr Thr Val Asp Cys Asn Asp Leu Phe Leu Thr Ala Val Pro
      50                  55                  60

 ccg gca ctc ccc gca ggc aca cag acc ctg ctc ctg cag agc aac agc      240
 Pro Ala Leu Pro Ala Gly Thr Gln Thr Leu Leu Leu Gln Ser Asn Ser
  65                  70                  75                  80

 att gtc cgt gtg gac cag agt gag ctg ggc tac ctg gcc aat ctc aca      288
 Ile Val Arg Val Asp Gln Ser Glu Leu Gly Tyr Leu Ala Asn Leu Thr
                  85                  90                  95

 gag ctg gac ctg tcc cag aac agc ttt tcg gat gcc cga gac tgt gat      336
 Glu Leu Asp Leu Ser Gln Asn Ser Phe Ser Asp Ala Arg Asp Cys Asp
             100                 105                 110

 ttc cat gcc ctg ccc cag ctg ctg agc ctg cac cta gag gag aac cag      384
 Phe His Ala Leu Pro Gln Leu Leu Ser Leu His Leu Glu Glu Asn Gln
         115                 120                 125

 ctg acc cgg ctg gag gac cac agc ttt gca ggg ctg gcc agc cta cag      432
 Leu Thr Arg Leu Glu Asp His Ser Phe Ala Gly Leu Ala Ser Leu Gln
     130                 135                 140

 gaa ctc tat ctc aac cac aac cag ctc tac cgc atc gcc ccc agg gcc      480
 Glu Leu Tyr Leu Asn His Asn Gln Leu Tyr Arg Ile Ala Pro Arg Ala
 145                 150                 155                 160

 ttt tct ggc ctc agc aac ttg ctg cgg ctg cac ctc aac tcc aac ctc      528
 Phe Ser Gly Leu Ser Asn Leu Leu Arg Leu His Leu Asn Ser Asn Leu
                 165                 170                 175

 ctg agg gcc att gac agc cgc tgg ttt gaa atg ctg ccc aac ttg gag      576
 Leu Arg Ala Ile Asp Ser Arg Trp Phe Glu Met Leu Pro Asn Leu Glu
             180                 185                 190

 ata ctc atg att ggc ggc aac aag gta gat gcc atc ctg gac atg aac      624
 Ile Leu Met Ile Gly Gly Asn Lys Val Asp Ala Ile Leu Asp Met Asn
         195                 200                 205

 ttc cgg ccc ctg gcc aac ctg cgt agc ctg gtg cta gca ggc atg aac      672
 Phe Arg Pro Leu Ala Asn Leu Arg Ser Leu Val Leu Ala Gly Met Asn
     210                 215                 220

 ctg cgg gag atc tcc gac tat gcc ctg gag ggg ctg caa agc ctg gag      720
 Leu Arg Glu Ile Ser Asp Tyr Ala Leu Glu Gly Leu Gln Ser Leu Glu
 225                 230                 235                 240

 agc ctc tcc ttc tat gac aac cag ctg gcc cgg gtg ccc agg cgg gca      768
 Ser Leu Ser Phe Tyr Asp Asn Gln Leu Ala Arg Val Pro Arg Arg Ala
                 245                 250                 255

 ctg gaa cag gtg ccc ggg ctc aag ttc cta gac ctc aac aag aac ccg      816
 Leu Glu Gln Val Pro Gly Leu Lys Phe Leu Asp Leu Asn Lys Asn Pro
             260                 265                 270

 ctc cag cgg gta ggg ccg ggg gac ttt gcc aac atg ctg cac ctt aag      864
 Leu Gln Arg Val Gly Pro Gly Asp Phe Ala Asn Met Leu His Leu Lys
         275                 280                 285

 gag ctg gga ctg aac aac atg gag gag ctg gtc tcc atc gac aag ttt      912
 Glu Leu Gly Leu Asn Asn Met Glu Glu Leu Val Ser Ile Asp Lys Phe
     290                 295                 300

 gcc ctg gtg aac ctc ccc gag ctg acc aag ctg gac atc acc aat aac      960
 Ala Leu Val Asn Leu Pro Glu Leu Thr Lys Leu Asp Ile Thr Asn Asn
 305                 310                 315                 320

 cca cgg ctg tcc ttc atc cac ccc cgc gcc ttc cac cac ctg ccc cag     1008
 Pro Arg Leu Ser Phe Ile His Pro Arg Ala Phe His His Leu Pro Gln
                 325                 330                 335

 atg gag acc ctc atg ctc aac aac aac gct ctc agt gcc ttg cac cag     1056
 Met Glu Thr Leu Met Leu Asn Asn Asn Ala Leu Ser Ala Leu His Gln
             340                 345                 350

 cag acg gtg gag tcc ctg ccc aac ctg cag gag gta ggt ctc cac ggc     1104
 Gln Thr Val Glu Ser Leu Pro Asn Leu Gln Glu Val Gly Leu His Gly
         355                 360                 365

 aac ccc atc cgc tgt gac tgt gtc atc cgc tgg gcc aat gcc acg ggc     1152
 Asn Pro Ile Arg Cys Asp Cys Val Ile Arg Trp Ala Asn Ala Thr Gly
     370                 375                 380

 acc cgt gtc cgc ttc atc gag ccg caa tcc acc ctg tgt gcg gag cct     1200
 Thr Arg Val Arg Phe Ile Glu Pro Gln Ser Thr Leu Cys Ala Glu Pro
 385                 390                 395                 400

 ccg gac ctc cag cgc ctc ccg gtc cgt gag gtg ccc ttc cgg gag atg     1248
 Pro Asp Leu Gln Arg Leu Pro Val Arg Glu Val Pro Phe Arg Glu Met
                 405                 410                 415

 acg gac cac tgt ttg ccc ctc atc tcc cca cga agc ttc ccc cca agc     1296
 Thr Asp His Cys Leu Pro Leu Ile Ser Pro Arg Ser Phe Pro Pro Ser
             420                 425                 430

 ctc cag gta gcc agt gga gag agc atg gtg ctg cat tgc cgg gca ctg     1344
 Leu Gln Val Ala Ser Gly Glu Ser Met Val Leu His Cys Arg Ala Leu
         435                 440                 445

 gcc gaa ccc gaa ccc gag atc tac tgg gtc act cca gct ggg ctt cga     1392
 Ala Glu Pro Glu Pro Glu Ile Tyr Trp Val Thr Pro Ala Gly Leu Arg
     450                 455                 460

 ctg aca cct gcc cat gca ggc agg agg tac cgg gtg tac ccc gag ggg     1440
 Leu Thr Pro Ala His Ala Gly Arg Arg Tyr Arg Val Tyr Pro Glu Gly
 465                 470                 475                 480

 acc ctg gag ctg cgg agg gtg aca gca gaa gag gca ggg cta tac acc     1488
 Thr Leu Glu Leu Arg Arg Val Thr Ala Glu Glu Ala Gly Leu Tyr Thr
                 485                 490                 495

 tgt gtg gcc cag aac ctg gtg ggg gct gac act aag acg gtt agt gtg     1536
 Cys Val Ala Gln Asn Leu Val Gly Ala Asp Thr Lys Thr Val Ser Val
             500                 505                 510

 gtt gtg ggc cgt gct ctc ctc cag cca ggc agg gac gaa gga cag ggg     1584
 Val Val Gly Arg Ala Leu Leu Gln Pro Gly Arg Asp Glu Gly Gln Gly
         515                 520                 525

 ctg gag ctc cgg gtg cag gag acc cac ccc tat cac atc ctg cta tct     1632
 Leu Glu Leu Arg Val Gln Glu Thr His Pro Tyr His Ile Leu Leu Ser
     530                 535                 540

 tgg gtc acc cca ccc aac aca gtg tcc acc aac ctc acc tgg tcc agt     1680
 Trp Val Thr Pro Pro Asn Thr Val Ser Thr Asn Leu Thr Trp Ser Ser
 545                 550                 555                 560

 gcc tcc tcc ctc cgg ggc cag ggg gcc aca gct ctg gcc cgc ctg cct     1728
 Ala Ser Ser Leu Arg Gly Gln Gly Ala Thr Ala Leu Ala Arg Leu Pro
                 565                 570                 575

 cgg gga acc cac agc tac aac att acc cgc ctc ctt cag gcc acg gag     1776
 Arg Gly Thr His Ser Tyr Asn Ile Thr Arg Leu Leu Gln Ala Thr Glu
             580                 585                 590

 tac tgg gcc tgc ctg caa gtg gcc ttt gct gat gcc cac acc cag ttg     1824
 Tyr Trp Ala Cys Leu Gln Val Ala Phe Ala Asp Ala His Thr Gln Leu
         595                 600                 605

 gct tgt ctg cca tgg ggc tca gag ctg ctc aag tcc ttg aat gtg aat     1872
 Ala Cys Leu Pro Trp Gly Ser Glu Leu Leu Lys Ser Leu Asn Val Asn
     610                 615                 620

 gct ttc ttc tca gaa gaa aat gtc agt tat ggg gac tta atc tgt gtc     1920
 Ala Phe Phe Ser Glu Glu Asn Val Ser Tyr Gly Asp Leu Ile Cys Val
 625                 630                 635                 640

 tca cct gaa tcc cca ggt cct gga ctg tta ggc tac agc aga gaa gtt     1968
 Ser Pro Glu Ser Pro Gly Pro Gly Leu Leu Gly Tyr Ser Arg Glu Val
                 645                 650                 655

 agt tac cgc act acc ttc tac ata aag aac aag cat gtg gat ggt gtg     2016
 Ser Tyr Arg Thr Thr Phe Tyr Ile Lys Asn Lys His Val Asp Gly Val
             660                 665                 670

 tac tcc tct cag ggg tgt gta aca ctc aac aga aac aat cag ggg cta     2064
 Tyr Ser Ser Gln Gly Cys Val Thr Leu Asn Arg Asn Asn Gln Gly Leu
         675                 680                 685

 act aca gag gat aaa gaa gag atg gca tcg ctt acg cca ctg ggg att     2112
 Thr Thr Glu Asp Lys Glu Glu Met Ala Ser Leu Thr Pro Leu Gly Ile
     690                 695                 700

 ata gga gct gct gga tac agt cct gat gaa act gtc aat cac aag tcc     2160
 Ile Gly Ala Ala Gly Tyr Ser Pro Asp Glu Thr Val Asn His Lys Ser
 705                 710                 715                 720

 ctg gtc ttc atc ctg ctc tcc cct ggc caa aga gtg agg gcc ttt gtc     2208
 Leu Val Phe Ile Leu Leu Ser Pro Gly Gln Arg Val Arg Ala Phe Val
                 725                 730                 735

 cct gga ctg tga                                                     2220
 Pro Gly Leu 






      <210> 672
      <211> 600
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (1)..(600)

      <400> 672
  atg tat tcc atg gtg tat atg tgc cac att ttc tta atc cag tct atc      48
  Met Tyr Ser Met Val Tyr Met Cys His Ile Phe Leu Ile Gln Ser Ile
    1               5                  10                  15

 att gat gga cac atg tcc ctg ggt tgt ttt tca gaa acc tgg acc cca       96
 Ile Asp Gly His Met Ser Leu Gly Cys Phe Ser Glu Thr Trp Thr Pro
              20                  25                  30

 cca aat gga tct gtt ggc atg tac aca tca gca atc caa atg tca gtg      144
 Pro Asn Gly Ser Val Gly Met Tyr Thr Ser Ala Ile Gln Met Ser Val
          35                  40                  45

 ttt agc ttt gct gca ctg ggt ggg cag acc gaa gtt cag ttt ggc gcc      192
 Phe Ser Phe Ala Ala Leu Gly Gly Gln Thr Glu Val Gln Phe Gly Ala
      50                  55                  60

 acc ata ctt ttt acc agc aac tat act ttt cgc tgt acc aaa agt gca      240
 Thr Ile Leu Phe Thr Ser Asn Tyr Thr Phe Arg Cys Thr Lys Ser Ala
  65                  70                  75                  80

 aaa ggg ttc caa ttt ctc cat atc ctt acc aac act tgc tat ttt ctg      288
 Lys Gly Phe Gln Phe Leu His Ile Leu Thr Asn Thr Cys Tyr Phe Leu
                  85                  90                  95

 ttt tta gag aga agc cac tat agc agg tat ggg ggt ggt atc aca gta      336
 Phe Leu Glu Arg Ser His Tyr Ser Arg Tyr Gly Gly Gly Ile Thr Val
             100                 105                 110

 ctg aga gag gag aaa gga aga aac cga ttc aat gga cat gaa cat gag      384
 Leu Arg Glu Glu Lys Gly Arg Asn Arg Phe Asn Gly His Glu His Glu
         115                 120                 125

 ccc ctg agg cct gag gac cat gtt ttt cat tgt gaa cca aag gct gac      432
 Pro Leu Arg Pro Glu Asp His Val Phe His Cys Glu Pro Lys Ala Asp
     130                 135                 140

 aaa cat tac cat ctt aag gtg gat aat gat gaa aat gag cat cag tta      480
 Lys His Tyr His Leu Lys Val Asp Asn Asp Glu Asn Glu His Gln Leu
 145                 150                 155                 160

 tct tta aga atg gtc agc tta gag gct ggt gca aat gat gaa ctg cag      528
 Ser Leu Arg Met Val Ser Leu Glu Ala Gly Ala Asn Asp Glu Leu Gln
                 165                 170                 175

 att gtt gac aca gag aca atg aat tac gaa ggc agt cca att aaa ata      576
 Ile Val Asp Thr Glu Thr Met Asn Tyr Glu Gly Ser Pro Ile Lys Ile
             180                 185                 190

 ata ctg gca act ggc cgg gca tga                                      600
 Ile Leu Ala Thr Gly Arg Ala 
         195





      <210> 673
      <211> 993
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (1)..(993)

      <400> 673
  atg gag gcc tgg ggt ggc cac agg gtg gct gtc agc ggt cag tac ctt      48
  Met Glu Ala Trp Gly Gly His Arg Val Ala Val Ser Gly Gln Tyr Leu
    1               5                  10                  15

 tgg agg ctg cca gtg ctg gtt gtc atg gaa acc agc cag cag tct tgt       96
 Trp Arg Leu Pro Val Leu Val Val Met Glu Thr Ser Gln Gln Ser Cys
              20                  25                  30

 agg aag cct gct gac tgg gag cca gac cac gtg acc aga gag aag ctg      144
 Arg Lys Pro Ala Asp Trp Glu Pro Asp His Val Thr Arg Glu Lys Leu
          35                  40                  45

 gac cgc att ctg gcc gtt atc caa ggc tcc cat cag aag gcc ctg gtg      192
 Asp Arg Ile Leu Ala Val Ile Gln Gly Ser His Gln Lys Ala Leu Val
      50                  55                  60

 atg tac tcc aac ctc gac ctg aag acc cag gag gcc tat gag atg gcc      240
 Met Tyr Ser Asn Leu Asp Leu Lys Thr Gln Glu Ala Tyr Glu Met Ala
  65                  70                  75                  80

 gtg aga ggc ctg atc cgg ccc atg aac aag tcc ccg atg ctg ata act      288
 Val Arg Gly Leu Ile Arg Pro Met Asn Lys Ser Pro Met Leu Ile Thr
                  85                  90                  95

 ggc atc cga tgc ctc tac ttt gca cct ccg gaa ttc ctc tta gag gtg      336
 Gly Ile Arg Cys Leu Tyr Phe Ala Pro Pro Glu Phe Leu Leu Glu Val
             100                 105                 110

 cag tgc atg cat gag acg cag aaa gag ctg cgg aag ttg gtt cat gaa      384
 Gln Cys Met His Glu Thr Gln Lys Glu Leu Arg Lys Leu Val His Glu
         115                 120                 125

 atc ggc ctg gaa cta aag acc act gct gtc tgc acc caa gtg cgg cgc      432
 Ile Gly Leu Glu Leu Lys Thr Thr Ala Val Cys Thr Gln Val Arg Arg
     130                 135                 140

 acg cgc gac ggc ttc ttc acg cta gac agt gcc ctc ctg agg acc cag      480
 Thr Arg Asp Gly Phe Phe Thr Leu Asp Ser Ala Leu Leu Arg Thr Gln
 145                 150                 155                 160

 tgg gac cta acc aac atc cag gat gct atc cgg gct gct acc cct cag      528
 Trp Asp Leu Thr Asn Ile Gln Asp Ala Ile Arg Ala Ala Thr Pro Gln
                 165                 170                 175

 agt tta gag cag tgc ctg aaa aaa tac tgt gga agg aat gcc aat gcc      576
 Ser Leu Glu Gln Cys Leu Lys Lys Tyr Cys Gly Arg Asn Ala Asn Ala
             180                 185                 190

 tac cta act gca gct ttc aag gtg ccg gat gac aaa tat ttt cga gta      624
 Tyr Leu Thr Ala Ala Phe Lys Val Pro Asp Asp Lys Tyr Phe Arg Val
         195                 200                 205

 ggg ttt ata ccg gat atg atc aaa caa acc att gag gcc act agc act      672
 Gly Phe Ile Pro Asp Met Ile Lys Gln Thr Ile Glu Ala Thr Ser Thr
     210                 215                 220

 cac cca aga cct aag gga aca gga gca gag cca cgt tca tca agg caa      720
 His Pro Arg Pro Lys Gly Thr Gly Ala Glu Pro Arg Ser Ser Arg Gln
 225                 230                 235                 240

 atg ctg agc gtg tgt gag atg cag gtg gaa agg atg tcg tct gat gtg      768
 Met Leu Ser Val Cys Glu Met Gln Val Glu Arg Met Ser Ser Asp Val
                 245                 250                 255

 aat ctg aca aaa tct tgt tcc cag ggg gca tct ggt ttg gct gtc ccc      816
 Asn Leu Thr Lys Ser Cys Ser Gln Gly Ala Ser Gly Leu Ala Val Pro
             260                 265                 270

 cac ggg ccc cac ctg gcc acg ctg gag ctc tgc cat gtg cca gcc act      864
 His Gly Pro His Leu Ala Thr Leu Glu Leu Cys His Val Pro Ala Thr
         275                 280                 285

 gta ttc aac aat gga cct aca agg act cct tgg acc ctc acc cca ttt      912
 Val Phe Asn Asn Gly Pro Thr Arg Thr Pro Trp Thr Leu Thr Pro Phe
     290                 295                 300

 tgc aga gga atg aaa cag agc ttc ctc gat tcc att ctc cac aca gag      960
 Cys Arg Gly Met Lys Gln Ser Phe Leu Asp Ser Ile Leu His Thr Glu
 305                 310                 315                 320

 ctg ctg gat tca tct gct tca aat cct cca tga                          993
 Leu Leu Asp Ser Ser Ala Ser Asn Pro Pro 
                 325                 330





      <210> 674
      <211> 2163
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (1)..(2163)

      <400> 674
  atg gcc tgt ttc ctc ctt ccg tgt gtc tgt ggc ctg ttt cct cct tcc      48
  Met Ala Cys Phe Leu Leu Pro Cys Val Cys Gly Leu Phe Pro Pro Ser
    1               5                  10                  15

 gtg cgt ctg tgg cgt ttc ctc cgt ccg tgc gtc tgt ggc ctg ttt cct       96
 Val Arg Leu Trp Arg Phe Leu Arg Pro Cys Val Cys Gly Leu Phe Pro
              20                  25                  30

 ccg tcc gtg cgt ctg tgg cgt ttc ctc cgt cgg tgc gtc tgt gac gtt      144
 Pro Ser Val Arg Leu Trp Arg Phe Leu Arg Arg Cys Val Cys Asp Val
          35                  40                  45

 tcc tcc gtc cgt gcg tct gtg acg ttt cct ccg tcc gtg cgt ctg tgg      192
 Ser Ser Val Arg Ala Ser Val Thr Phe Pro Pro Ser Val Arg Leu Trp
      50                  55                  60

 cgt ttc ctc cgt cgg tgc gtc tgt gac gtt tcc tcc gtc cgt gcg tct      240
 Arg Phe Leu Arg Arg Cys Val Cys Asp Val Ser Ser Val Arg Ala Ser
  65                  70                  75                  80

 gtg acg ttt cct ccg tcc gtg cgt ctg tgg cct gtt tcc tcc gtc cgt      288
 Val Thr Phe Pro Pro Ser Val Arg Leu Trp Pro Val Ser Ser Val Arg
                  85                  90                  95

 gcg tct gtg gcc tgt ttc ctc cgt ccg tgc gtc tgt ggc gtt tcc tcc      336
 Ala Ser Val Ala Cys Phe Leu Arg Pro Cys Val Cys Gly Val Ser Ser
             100                 105                 110

 gtc cgt gcg cct gtg gtc tgt ttc ctc cgt ccg tgc gtc tgt gac gtt      384
 Val Arg Ala Pro Val Val Cys Phe Leu Arg Pro Cys Val Cys Asp Val
         115                 120                 125

 tcc tcc gtc cgt gcg tct gtg acg ttt cct ccg tcc gtg cgt ctg tgg      432
 Ser Ser Val Arg Ala Ser Val Thr Phe Pro Pro Ser Val Arg Leu Trp
     130                 135                 140

 cct gtt tcc tcc gtc cgt gcg tct gtg gcg ttt cct ccg tcc gtg cgt      480
 Pro Val Ser Ser Val Arg Ala Ser Val Ala Phe Pro Pro Ser Val Arg
 145                 150                 155                 160

 ctg tgg cgt ttc ctc cgt ctg tgg atc tgt ggt gtt tcc tct gtc tct      528
 Leu Trp Arg Phe Leu Arg Leu Trp Ile Cys Gly Val Ser Ser Val Ser
                 165                 170                 175

 gtg cca gag cct tgg tac ctg tct cag ttc tgg aat cta ctc tgt cct      576
 Val Pro Glu Pro Trp Tyr Leu Ser Gln Phe Trp Asn Leu Leu Cys Pro
             180                 185                 190

 tgt tgc ctt cca ttc acc gac agc cgt ctg tct tcc tgt cac tcc ttc      624
 Cys Cys Leu Pro Phe Thr Asp Ser Arg Leu Ser Ser Cys His Ser Phe
         195                 200                 205

 aac acg gag tcc agc agt gtg cac aca gcc tgg cag tgc tgt gca cca      672
 Asn Thr Glu Ser Ser Ser Val His Thr Ala Trp Gln Cys Cys Ala Pro
     210                 215                 220

 gtg ctg ctg gcc agc tgt ttt ttc aat gta ctg gca gaa aat caa gct      720
 Val Leu Leu Ala Ser Cys Phe Phe Asn Val Leu Ala Glu Asn Gln Ala
 225                 230                 235                 240

 gac acc cgg gtt cct ttc tcc ctg ggt act gac cag gtg gga gag gag      768
 Asp Thr Arg Val Pro Phe Ser Leu Gly Thr Asp Gln Val Gly Glu Glu
                 245                 250                 255

 ggg cgt tgt gga act gag gtg cat aag agg gaa ttt aat gat gcc ctg      816
 Gly Arg Cys Gly Thr Glu Val His Lys Arg Glu Phe Asn Asp Ala Leu
             260                 265                 270

 aga gac aga tgc atc tgg ggg acg ttc tgc agg acg ttg gcc cca gac      864
 Arg Asp Arg Cys Ile Trp Gly Thr Phe Cys Arg Thr Leu Ala Pro Asp
         275                 280                 285

 tct cga aaa gtc atc aca gat aaa ggg tgt gag gct gtc cct gac gaa      912
 Ser Arg Lys Val Ile Thr Asp Lys Gly Cys Glu Ala Val Pro Asp Glu
     290                 295                 300

 gat ggg gaa gga gag tca ctc ggc gca gtg tgt ggc cca gat aga aaa      960
 Asp Gly Glu Gly Glu Ser Leu Gly Ala Val Cys Gly Pro Asp Arg Lys
 305                 310                 315                 320

 gac gtt ttc ggg aga att gtg ctt att gaa tat aaa gtg gac agc gat     1008
 Asp Val Phe Gly Arg Ile Val Leu Ile Glu Tyr Lys Val Asp Ser Asp
                 325                 330                 335

 gct ctg aaa tgg ttc ttg tct gcc gat gat ggt tct gcg gct gca gag     1056
 Ala Leu Lys Trp Phe Leu Ser Ala Asp Asp Gly Ser Ala Ala Ala Glu
             340                 345                 350

 ggt cct tta ttc tta ggg aac gct tac ggt gct ggc cgt gga gtc tgg     1104
 Gly Pro Leu Phe Leu Gly Asn Ala Tyr Gly Ala Gly Arg Gly Val Trp
         355                 360                 365

 gtt cac acc ggt gcc cgc atg gtc tcc agt tac ggt gct ggc cgt gga     1152
 Val His Thr Gly Ala Arg Met Val Ser Ser Tyr Gly Ala Gly Arg Gly
     370                 375                 380

 gtc tgg gtt cac acc ggt gcc cgc gtg gtc tcc agt tac ggt gct ggc     1200
 Val Trp Val His Thr Gly Ala Arg Val Val Ser Ser Tyr Gly Ala Gly
 385                 390                 395                 400

 cgt gga gtc tgg gtt cac acc ggt gcc cgc gtg gtc tcc agt tac ggt     1248
 Arg Gly Val Trp Val His Thr Gly Ala Arg Val Val Ser Ser Tyr Gly
                 405                 410                 415

 gct ggc cgt cgg gtc tgg gtt cac acc ggt gcc cgc gtg gtc tcc agt     1296
 Ala Gly Arg Arg Val Trp Val His Thr Gly Ala Arg Val Val Ser Ser
             420                 425                 430

 tac ggt gct ggc cgt gga gtc tgg gtt cac acc ggt gcc cgc gtg gtc     1344
 Tyr Gly Ala Gly Arg Gly Val Trp Val His Thr Gly Ala Arg Val Val
         435                 440                 445

 tcc agt tac ggt gct ggc cgt gga gtc tgg gtt cac acc ggt gcc cgc     1392
 Ser Ser Tyr Gly Ala Gly Arg Gly Val Trp Val His Thr Gly Ala Arg
     450                 455                 460

 gtg gtc tcc agt tac gtt acg gtg ctg gcc gtg gag tct ggg ttc aca     1440
 Val Val Ser Ser Tyr Val Thr Val Leu Ala Val Glu Ser Gly Phe Thr
 465                 470                 475                 480

 ccg gtg ccc gcg tgg tct cca gtt acg gtg ctg gcc gtg gag tct ggg     1488
 Pro Val Pro Ala Trp Ser Pro Val Thr Val Leu Ala Val Glu Ser Gly
                 485                 490                 495

 ttc aca ccg gtg ccc gcg tgg tct cca gtt acg gtg ctg gcc gtc ggg     1536
 Phe Thr Pro Val Pro Ala Trp Ser Pro Val Thr Val Leu Ala Val Gly
             500                 505                 510

 tct gag ttc aca ccg gtg ccc gca tgg tct cca gtt acg gtg ctg gcc     1584
 Ser Glu Phe Thr Pro Val Pro Ala Trp Ser Pro Val Thr Val Leu Ala
         515                 520                 525

 gtg gag tct ggg ttc aca ccg gtg ccc gca tgg tct cca gtt acg gtg     1632
 Val Glu Ser Gly Phe Thr Pro Val Pro Ala Trp Ser Pro Val Thr Val
     530                 535                 540

 ctg gct gtc ggg tct gag ttc acg ctg ggt tgg ggc aga gga gat ggg     1680
 Leu Ala Val Gly Ser Glu Phe Thr Leu Gly Trp Gly Arg Gly Asp Gly
 545                 550                 555                 560

 ggc gga gga gcc agg cct cca acc cgc ttt ccc ctg gag ctc agc cag     1728
 Gly Gly Gly Ala Arg Pro Pro Thr Arg Phe Pro Leu Glu Leu Ser Gln
                 565                 570                 575

 aat tcc cca ttg agg agc cct cag ctc cct gag agc cag gag ctc ttg     1776
 Asn Ser Pro Leu Arg Ser Pro Gln Leu Pro Glu Ser Gln Glu Leu Leu
             580                 585                 590

 cgg aga agc cac tgt ctg cac gcc acc tgc ttc gat gac cct gct ctg     1824
 Arg Arg Ser His Cys Leu His Ala Thr Cys Phe Asp Asp Pro Ala Leu
         595                 600                 605

 cca tcc ctg tgc tcc aag ggc cgg gcc ctg ccg ttg cct gtg cca gac     1872
 Pro Ser Leu Cys Ser Lys Gly Arg Ala Leu Pro Leu Pro Val Pro Asp
     610                 615                 620

 ggg tct cag gga gat gcc ggc cag cag gtt gtt aga gtt gga agt gag     1920
 Gly Ser Gln Gly Asp Ala Gly Gln Gln Val Val Arg Val Gly Ser Glu
 625                 630                 635                 640

 tgt gga gat gag tta atc cga ctt tat tct ttc acg gat gag aaa gcg     1968
 Cys Gly Asp Glu Leu Ile Arg Leu Tyr Ser Phe Thr Asp Glu Lys Ala
                 645                 650                 655

 aat tat ctt cag caa ggg aat aac cac agg ccc atc cac aag gac cat     2016
 Asn Tyr Leu Gln Gln Gly Asn Asn His Arg Pro Ile His Lys Asp His
             660                 665                 670

 ttc tgg ctg att tat gga aca ctg ttc tac ctg gtt aat ttt gga cgt     2064
 Phe Trp Leu Ile Tyr Gly Thr Leu Phe Tyr Leu Val Asn Phe Gly Arg
         675                 680                 685

 tat ctc agc ctg aga ggg aag cag cga acc cag ctg aaa atc cag ttc     2112
 Tyr Leu Ser Leu Arg Gly Lys Gln Arg Thr Gln Leu Lys Ile Gln Phe
     690                 695                 700

 tct tgt acg gca gag cgg ctg gtg aca cag gtc cag atg ctg gga tgc     2160
 Ser Cys Thr Ala Glu Arg Leu Val Thr Gln Val Gln Met Leu Gly Cys
 705                 710                 715                 720

 tga                                                                 2163
 






      <210> 675
      <211> 1608
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (1)..(1608)

      <400> 675
  atg cgc aac cta gtg aat gtc att tac att gta gtc gtg ctt agc agc      48
  Met Arg Asn Leu Val Asn Val Ile Tyr Ile Val Val Val Leu Ser Ser
    1               5                  10                  15

 tcg gac cgg ttg cct ttt ggc att gag gag aat ggg ggc aca ccg ttc       96
 Ser Asp Arg Leu Pro Phe Gly Ile Glu Glu Asn Gly Gly Thr Pro Phe
              20                  25                  30

 ctc acc gca gct tca gga agg cat cac cac cag cac cag cat cag cat      144
 Leu Thr Ala Ala Ser Gly Arg His His His Gln His Gln His Gln His
          35                  40                  45

 cag cac cag cac cac tca aac tac agc ctc tca ctg acc ctg gag aac      192
 Gln His Gln His His Ser Asn Tyr Ser Leu Ser Leu Thr Leu Glu Asn
      50                  55                  60

 aaa gag ggg cct ctg agg tcc cca aac tcc agc agc aag tcc ctt aca      240
 Lys Glu Gly Pro Leu Arg Ser Pro Asn Ser Ser Ser Lys Ser Leu Thr
  65                  70                  75                  80

 aaa ctg agt cca gga aca cct gcc ttg ttc agt gaa gcc gct gcc cat      288
 Lys Leu Ser Pro Gly Thr Pro Ala Leu Phe Ser Glu Ala Ala Ala His
                  85                  90                  95

 cta aag aag ctg gaa ctg gaa act gtg aag gct gct gga ccc tgg cct      336
 Leu Lys Lys Leu Glu Leu Glu Thr Val Lys Ala Ala Gly Pro Trp Pro
             100                 105                 110

 cct ctg cac atc aac ata aac aag gct gaa gaa aag aaa gtc tcg gag      384
 Pro Leu His Ile Asn Ile Asn Lys Ala Glu Glu Lys Lys Val Ser Glu
         115                 120                 125

 aaa act ctt cag act cca ctt ttg cct tcc cct gtt gcg gat cat gtg      432
 Lys Thr Leu Gln Thr Pro Leu Leu Pro Ser Pro Val Ala Asp His Val
     130                 135                 140

 aag tgt aac att ctg aaa gcc cag ttg gaa aat gct tcc cga gtg aac      480
 Lys Cys Asn Ile Leu Lys Ala Gln Leu Glu Asn Ala Ser Arg Val Asn
 145                 150                 155                 160

 atc cag ctg gat ctg cca gtg ttg gaa aac tgc aaa ttg tat tca gct      528
 Ile Gln Leu Asp Leu Pro Val Leu Glu Asn Cys Lys Leu Tyr Ser Ala
                 165                 170                 175

 gtg act gca gga gga cct gct gct gcc cac aag aag cag caa ggc tgg      576
 Val Thr Ala Gly Gly Pro Ala Ala Ala His Lys Lys Gln Gln Gly Trp
             180                 185                 190

 ggt gac tcg cag gag cag gaa gca gac aag gag cgc ccc atg tgg aca      624
 Gly Asp Ser Gln Glu Gln Glu Ala Asp Lys Glu Arg Pro Met Trp Thr
         195                 200                 205

 gaa cct atc atg gag cca cct ggc aaa gca gac atg aga agt cct att      672
 Glu Pro Ile Met Glu Pro Pro Gly Lys Ala Asp Met Arg Ser Pro Ile
     210                 215                 220

 cct att cgt gtg gaa act gcc cag cca gct gtg gaa aag ccg gaa atc      720
 Pro Ile Arg Val Glu Thr Ala Gln Pro Ala Val Glu Lys Pro Glu Ile
 225                 230                 235                 240

 aag cct ccc cga gtg agg aag tta aca aga cag tat agt ttt aac cgc      768
 Lys Pro Pro Arg Val Arg Lys Leu Thr Arg Gln Tyr Ser Phe Asn Arg
                 245                 250                 255

 agt gat gaa gac gac ctc cct cca gac ctg gcc gag gca gtg gga gtg      816
 Ser Asp Glu Asp Asp Leu Pro Pro Asp Leu Ala Glu Ala Val Gly Val
             260                 265                 270

 acc aca tct aca acc aca aac acc aca acg gcc gcc aca caa gtc tcc      864
 Thr Thr Ser Thr Thr Thr Asn Thr Thr Thr Ala Ala Thr Gln Val Ser
         275                 280                 285

 gtg ccg ctg ccg tcc ccc aag gtc cag aat gtc agc tcg cct cac aag      912
 Val Pro Leu Pro Ser Pro Lys Val Gln Asn Val Ser Ser Pro His Lys
     290                 295                 300

 tca gaa ggc aaa ggc ctg ctg tcc cct ggg gcc aag agc ccc tct gac      960
 Ser Glu Gly Lys Gly Leu Leu Ser Pro Gly Ala Lys Ser Pro Ser Asp
 305                 310                 315                 320

 cga gga ggt gcc ttt acc ctg gag ccg ggt gat ctt ctg atg gat ttc     1008
 Arg Gly Gly Ala Phe Thr Leu Glu Pro Gly Asp Leu Leu Met Asp Phe
                 325                 330                 335

 aca gaa gcc act cct ctg cat cag aaa tgc aag cag cag ccc tcc tac     1056
 Thr Glu Ala Thr Pro Leu His Gln Lys Cys Lys Gln Gln Pro Ser Tyr
             340                 345                 350

 ctg ttg gca gag ccc gcc agc aac ccc cac tgt gcc cac tct cgc tgt     1104
 Leu Leu Ala Glu Pro Ala Ser Asn Pro His Cys Ala His Ser Arg Cys
         355                 360                 365

 tct cct cca ctc tct ctc ccc atg aag gaa gag acc act gga gtt tgc     1152
 Ser Pro Pro Leu Ser Leu Pro Met Lys Glu Glu Thr Thr Gly Val Cys
     370                 375                 380

 atg tac cct cca atc aaa acg agg ctg ata aaa aca ttc ccg gtt gat     1200
 Met Tyr Pro Pro Ile Lys Thr Arg Leu Ile Lys Thr Phe Pro Val Asp
 385                 390                 395                 400

 aca atg aac ccg ttt cct gat act ttc acc aca ggg cca cag ttt act     1248
 Thr Met Asn Pro Phe Pro Asp Thr Phe Thr Thr Gly Pro Gln Phe Thr
                 405                 410                 415

 gca gac ttc aga gac agt aaa tta cag tgc tgt cct ggc ccg act tcc     1296
 Ala Asp Phe Arg Asp Ser Lys Leu Gln Cys Cys Pro Gly Pro Thr Ser
             420                 425                 430

 ccg ctg atc cca gca gcg acc ctg agg cct ttg aca gag acc gtc tcc     1344
 Pro Leu Ile Pro Ala Ala Thr Leu Arg Pro Leu Thr Glu Thr Val Ser
         435                 440                 445

 aca gtg cag acc att tac acc acc cgg aaa cct gtt tct ctg gca gcc     1392
 Thr Val Gln Thr Ile Tyr Thr Thr Arg Lys Pro Val Ser Leu Ala Ala
     450                 455                 460

 aga gac act ccg gca gga act gga gag aga gaa gat gat gaa aag act     1440
 Arg Asp Thr Pro Ala Gly Thr Gly Glu Arg Glu Asp Asp Glu Lys Thr
 465                 470                 475                 480

 gtt gat gac cga act gtg aaa ttc tcc cct tgt cac ctg gaa gat ggc     1488
 Val Asp Asp Arg Thr Val Lys Phe Ser Pro Cys His Leu Glu Asp Gly
                 485                 490                 495

 atg agt tca cag atg ttg aag ttt ctg aag gtt gac gtc act gga agt     1536
 Met Ser Ser Gln Met Leu Lys Phe Leu Lys Val Asp Val Thr Gly Ser
             500                 505                 510

 ctg acc aca aac aag ttg gct gtt act gta ttt gaa acc cag tac ctt     1584
 Leu Thr Thr Asn Lys Leu Ala Val Thr Val Phe Glu Thr Gln Tyr Leu
         515                 520                 525

 tgg cag ctc acc tct aac cag taa                                     1608
 Trp Gln Leu Thr Ser Asn Gln 
     530                 535





      <210> 676
      <211> 1056
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (1)..(1056)

      <400> 676
  atg act gtc ctt ttt tac ttg gct gac ttg tgt tca ttc att tac ccc      48
  Met Thr Val Leu Phe Tyr Leu Ala Asp Leu Cys Ser Phe Ile Tyr Pro
    1               5                  10                  15

 ata ccc ttt gcc ccc atc tat aag tat ggc tat aag tat atc aag aag       96
 Ile Pro Phe Ala Pro Ile Tyr Lys Tyr Gly Tyr Lys Tyr Ile Lys Lys
              20                  25                  30

 act ggc ata aat tgg aca gat gat gaa aaa aga agc tac aag gat aaa      144
 Thr Gly Ile Asn Trp Thr Asp Asp Glu Lys Arg Ser Tyr Lys Asp Lys
          35                  40                  45

 gga ata gtt caa act caa gaa ata ttg cag tat ttg ctc ccc atc gtg      192
 Gly Ile Val Gln Thr Gln Glu Ile Leu Gln Tyr Leu Leu Pro Ile Val
      50                  55                  60

 cat agc act aaa aac atg caa acc act cag ata aaa cag cta ttc aat      240
 His Ser Thr Lys Asn Met Gln Thr Thr Gln Ile Lys Gln Leu Phe Asn
  65                  70                  75                  80

 cca aga acc aac ttc caa atc caa cat cac act gtt tac aat agc aaa      288
 Pro Arg Thr Asn Phe Gln Ile Gln His His Thr Val Tyr Asn Ser Lys
                  85                  90                  95

 gac atg gaa cca acc caa ata ccc atc agt gat aga ctg gat aaa gaa      336
 Asp Met Glu Pro Thr Gln Ile Pro Ile Ser Asp Arg Leu Asp Lys Glu
             100                 105                 110

 aat gtg gcc ata tac acc atg gaa tac tat gca gcc ata aaa agg aat      384
 Asn Val Ala Ile Tyr Thr Met Glu Tyr Tyr Ala Ala Ile Lys Arg Asn
         115                 120                 125

 ggg atc tgc cag gca cgg tgg ctc acg cct ata atc cca gct ctt tgg      432
 Gly Ile Cys Gln Ala Arg Trp Leu Thr Pro Ile Ile Pro Ala Leu Trp
     130                 135                 140

 gag gcc aag gaa atc ttg gac ttt gat caa gct cag cag ata aaa tgc      480
 Glu Ala Lys Glu Ile Leu Asp Phe Asp Gln Ala Gln Gln Ile Lys Cys
 145                 150                 155                 160

 ttt aat agt aat ttg ttc ctg tgc aat atc tgt ttc tgt aag aag ctg      528
 Phe Asn Ser Asn Leu Phe Leu Cys Asn Ile Cys Phe Cys Lys Lys Leu
                 165                 170                 175

 ggt agt gaa tgc atg tac ttc ttg gag tgc agg cat gtg tac tgc aaa      576
 Gly Ser Glu Cys Met Tyr Phe Leu Glu Cys Arg His Val Tyr Cys Lys
             180                 185                 190

 gac tgt ctg aag gac tac ttt gaa atc cag atc aga gat ggc cag gtt      624
 Asp Cys Leu Lys Asp Tyr Phe Glu Ile Gln Ile Arg Asp Gly Gln Val
         195                 200                 205

 caa tgc ctc aac tgc cca gaa cca aag tgc cct tca gtg gcc act act      672
 Gln Cys Leu Asn Cys Pro Glu Pro Lys Cys Pro Ser Val Ala Thr Thr
     210                 215                 220

 ggt cag gtc aaa gag cta gtg gaa gca gag tta ttt gcc tat tat gac      720
 Gly Gln Val Lys Glu Leu Val Glu Ala Glu Leu Phe Ala Tyr Tyr Asp
 225                 230                 235                 240

 tgc ctt ctc ctc cag tcc acc ttg gac ctg atg gca gat gtg gtg tac      768
 Cys Leu Leu Leu Gln Ser Thr Leu Asp Leu Met Ala Asp Val Val Tyr
                 245                 250                 255

 tgc ccc cac gca tgc tgc cag ctg cct gtg atg cag gag cct ggc tac      816
 Cys Pro His Ala Cys Cys Gln Leu Pro Val Met Gln Glu Pro Gly Tyr
             260                 265                 270

 atc atg ggt atc tgc tcc agc tgc aat ttt gcc ttc tgt acc ttg tgc      864
 Ile Met Gly Ile Cys Ser Ser Cys Asn Phe Ala Phe Cys Thr Leu Cys
         275                 280                 285

 agg ttg acc tac cat ggg gtc tct cca tgt aag gtg act gca gag aaa      912
 Arg Leu Thr Tyr His Gly Val Ser Pro Cys Lys Val Thr Ala Glu Lys
     290                 295                 300

 tta ata gac tta cta aat gaa tac ctg caa gca gat aag gcc aat aaa      960
 Leu Ile Asp Leu Leu Asn Glu Tyr Leu Gln Ala Asp Lys Ala Asn Lys
 305                 310                 315                 320

 aga ctt ttg gaa caa agg tat gat aag agg gtg att cag aag gca ctg     1008
 Arg Leu Leu Glu Gln Arg Tyr Asp Lys Arg Val Ile Gln Lys Ala Leu
                 325                 330                 335

 gaa gag atg gaa agt aag gag tgg cta gag aaa aac ttc aag aac tga     1056
 Glu Glu Met Glu Ser Lys Glu Trp Leu Glu Lys Asn Phe Lys Asn 
             340                 345                 350





      <210> 677
      <211> 753
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (1)..(753)

      <400> 677
  atg gtc ttc tct atc ctt caa gtt gct cag gcc aaa act ttg gct ctc      48
  Met Val Phe Ser Ile Leu Gln Val Ala Gln Ala Lys Thr Leu Ala Leu
    1               5                  10                  15

 gtc ttt gac gcc tat tta ttt tct cac acc cca caa cta att cat cag       96
 Val Phe Asp Ala Tyr Leu Phe Ser His Thr Pro Gln Leu Ile His Gln
              20                  25                  30

 cat att cgg aga atc aaa agg ttt acc tgg ttt gct ctt cat aag ctt      144
 His Ile Arg Arg Ile Lys Arg Phe Thr Trp Phe Ala Leu His Lys Leu
          35                  40                  45

 tac aag gag gtg tgt gca tgc aca cat act tct ata gca ttt agc gag      192
 Tyr Lys Glu Val Cys Ala Cys Thr His Thr Ser Ile Ala Phe Ser Glu
      50                  55                  60

 gac aat aag aaa ttt gat ggt tat gcc act cac tgc aca ctt agg gac      240
 Asp Asn Lys Lys Phe Asp Gly Tyr Ala Thr His Cys Thr Leu Arg Asp
  65                  70                  75                  80

 atc ata gca tat aaa aga aat cca att aag agt tgt ttg gag gtg ggt      288
 Ile Ile Ala Tyr Lys Arg Asn Pro Ile Lys Ser Cys Leu Glu Val Gly
                  85                  90                  95

 act gaa gga aaa gtt gag ctt tct aga gag gtt gtc ctg agg gtt aag      336
 Thr Glu Gly Lys Val Glu Leu Ser Arg Glu Val Val Leu Arg Val Lys
             100                 105                 110

 ata aga ggc cgg cag ttg cct tac aaa ggt cat tgc ttg aaa act tca      384
 Ile Arg Gly Arg Gln Leu Pro Tyr Lys Gly His Cys Leu Lys Thr Ser
         115                 120                 125

 aaa cac cat atg gac cta att gtg gtt tat ttt ggc aaa aag gaa gac      432
 Lys His His Met Asp Leu Ile Val Val Tyr Phe Gly Lys Lys Glu Asp
     130                 135                 140

 act gta gaa caa ttg agg cat tac att cta caa ttc cat tac ttt cat      480
 Thr Val Glu Gln Leu Arg His Tyr Ile Leu Gln Phe His Tyr Phe His
 145                 150                 155                 160

 ccc tct cag ttt tat tac tgt gtc att aaa ggc aac ttg act gag gac      528
 Pro Ser Gln Phe Tyr Tyr Cys Val Ile Lys Gly Asn Leu Thr Glu Asp
                 165                 170                 175

 act gac gcc cac agc act caa gtg act gtt cca ggt caa ata gct gat      576
 Thr Asp Ala His Ser Thr Gln Val Thr Val Pro Gly Gln Ile Ala Asp
             180                 185                 190

 gca gaa aag gcc ttt gac aaa att caa cag ccc ttc atg cta aaa act      624
 Ala Glu Lys Ala Phe Asp Lys Ile Gln Gln Pro Phe Met Leu Lys Thr
         195                 200                 205

 ctc gat aaa tta ggt att gac ggg atg tat atc aaa atc ata aga gct      672
 Leu Asp Lys Leu Gly Ile Asp Gly Met Tyr Ile Lys Ile Ile Arg Ala
     210                 215                 220

 att tat gac aaa ccc aca gcc aat atc ata ctg aat ggg caa aaa ctg      720
 Ile Tyr Asp Lys Pro Thr Ala Asn Ile Ile Leu Asn Gly Gln Lys Leu
 225                 230                 235                 240

 gaa gca ttc cct ttg aaa act ggc aca aga tag                          753
 Glu Ala Phe Pro Leu Lys Thr Gly Thr Arg 
                 245                 250





      <210> 678
      <211> 675
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (1)..(675)

      <400> 678
  atg atc atg gtc gga ttc ctg ggg aat ttc ttt ctt ctc tac cac tat      48
  Met Ile Met Val Gly Phe Leu Gly Asn Phe Phe Leu Leu Tyr His Tyr
    1               5                  10                  15

 agt ttc ctt tgt ttc acc aga gat gac ata att cta tac cta gat aac       96
 Ser Phe Leu Cys Phe Thr Arg Asp Asp Ile Ile Leu Tyr Leu Asp Asn
              20                  25                  30

 tcc atg gtc tca gcc caa aag ctc ctt cag ctg ata gac aac ttc agc      144
 Ser Met Val Ser Ala Gln Lys Leu Leu Gln Leu Ile Asp Asn Phe Ser
          35                  40                  45

 aaa gtt tca gaa tac aaa atc aac ata caa aaa tca cta gca ttc ctg      192
 Lys Val Ser Glu Tyr Lys Ile Asn Ile Gln Lys Ser Leu Ala Phe Leu
      50                  55                  60

 tac acc aac aac agc caa gct gag agc caa atc agg aag gca atc ccg      240
 Tyr Thr Asn Asn Ser Gln Ala Glu Ser Gln Ile Arg Lys Ala Ile Pro
  65                  70                  75                  80

 ttc aca atc acc aca aaa aga ata gaa tac cta gga ata cag ctc acc      288
 Phe Thr Ile Thr Thr Lys Arg Ile Glu Tyr Leu Gly Ile Gln Leu Thr
                  85                  90                  95

 agg aag gtg aaa gac ccc tac aga gga gtt ctg agc ttc tcc acc cta      336
 Arg Lys Val Lys Asp Pro Tyr Arg Gly Val Leu Ser Phe Ser Thr Leu
             100                 105                 110

 ggg acc agg gag tat ggc tgg gat gag cca gcc ctc agt gcg aaa gac      384
 Gly Thr Arg Glu Tyr Gly Trp Asp Glu Pro Ala Leu Ser Ala Lys Asp
         115                 120                 125

 ata ggc cac ctg ggt ggc cat ggc aca ggt ttg tac cac agc aca gag      432
 Ile Gly His Leu Gly Gly His Gly Thr Gly Leu Tyr His Ser Thr Glu
     130                 135                 140

 gcc cct gga gcc agc cag tct gaa gga caa act cgg cag gtt gtg ccc      480
 Ala Pro Gly Ala Ser Gln Ser Glu Gly Gln Thr Arg Gln Val Val Pro
 145                 150                 155                 160

 cat gtg agg aac gct aca atg gat cat gac aga aac ctc aaa aat gaa      528
 His Val Arg Asn Ala Thr Met Asp His Asp Arg Asn Leu Lys Asn Glu
                 165                 170                 175

 ggt gaa gag att gcg caa tat ctt aga cat cgc ttc atc tat cta tct      576
 Gly Glu Glu Ile Ala Gln Tyr Leu Arg His Arg Phe Ile Tyr Leu Ser
             180                 185                 190

 atc tat cta tct atc tat cta tct atc tat cta cct acc tac cta cct      624
 Ile Tyr Leu Ser Ile Tyr Leu Ser Ile Tyr Leu Pro Thr Tyr Leu Pro
         195                 200                 205

 acc tac cta tct tta tat cta ttc atc cat cca tcc atc cag atg tat      672
 Thr Tyr Leu Ser Leu Tyr Leu Phe Ile His Pro Ser Ile Gln Met Tyr
     210                 215                 220

 tag                                                                  675
 






      <210> 679
      <211> 720
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (1)..(720)

      <400> 679
  atg act ggc ctt gac tgg cag tat ctg gtc atg atc ctg ctg ctt cct      48
  Met Thr Gly Leu Asp Trp Gln Tyr Leu Val Met Ile Leu Leu Leu Pro
    1               5                  10                  15

 gcc cag cca agg tcc tgg gac tca gag gct gta caa cac tgt ggg gat       96
 Ala Gln Pro Arg Ser Trp Asp Ser Glu Ala Val Gln His Cys Gly Asp
              20                  25                  30

 gga gaa ata ggc cct gtg gat gtg gac tca act atc aga gca ggt gac      144
 Gly Glu Ile Gly Pro Val Asp Val Asp Ser Thr Ile Arg Ala Gly Asp
          35                  40                  45

 agt gga gac agg caa aga tat ctg cat gac agg agt aag ctg ggg aaa      192
 Ser Gly Asp Arg Gln Arg Tyr Leu His Asp Arg Ser Lys Leu Gly Lys
      50                  55                  60

 gag aag cag aga gat gcc aaa ggc tca ggg aca tgg atg aag ctg gaa      240
 Glu Lys Gln Arg Asp Ala Lys Gly Ser Gly Thr Trp Met Lys Leu Glu
  65                  70                  75                  80

 atc atc att ctc agc aaa cta tcg caa gga caa aaa acc aaa cat ggc      288
 Ile Ile Ile Leu Ser Lys Leu Ser Gln Gly Gln Lys Thr Lys His Gly
                  85                  90                  95

 atg ttc tca ctc ata gct tcc acc acc tcc aaa att gct tcc atc att      336
 Met Phe Ser Leu Ile Ala Ser Thr Thr Ser Lys Ile Ala Ser Ile Ile
             100                 105                 110

 acc aaa tcc att ata gcc atc ccc acc gcc acc ata acc acc acc acc      384
 Thr Lys Ser Ile Ile Ala Ile Pro Thr Ala Thr Ile Thr Thr Thr Thr
         115                 120                 125

 atg act gcc acc aaa gcc acc atg aca act gaa gct tcc tcc acg acc      432
 Met Thr Ala Thr Lys Ala Thr Met Thr Thr Glu Ala Ser Ser Thr Thr
     130                 135                 140

 acc acc tcc atg acc atg atc aaa ggc ttt cct aac ttc aca gtt gtg      480
 Thr Thr Ser Met Thr Met Ile Lys Gly Phe Pro Asn Phe Thr Val Val
 145                 150                 155                 160

 gtc att cac act atg gta ttt ctg aat gac agt ctt atc cat gga gtc      528
 Val Ile His Thr Met Val Phe Leu Asn Asp Ser Leu Ile His Gly Val
                 165                 170                 175

 atg gtt gtc aaa ggt tac aaa ggc aaa atc cct ttt ctt acc act gcc      576
 Met Val Val Lys Gly Tyr Lys Gly Lys Ile Pro Phe Leu Thr Thr Ala
             180                 185                 190

 tca gtc gac tgg att aag aaa acg tgg cac ata tac acc atg gaa tac      624
 Ser Val Asp Trp Ile Lys Lys Thr Trp His Ile Tyr Thr Met Glu Tyr
         195                 200                 205

 tac gca gcc gta aaa aag gat gag ttc atg tcc ttt gta ggg aca tgg      672
 Tyr Ala Ala Val Lys Lys Asp Glu Phe Met Ser Phe Val Gly Thr Trp
     210                 215                 220

 atg aag ctg gaa acc atc att ctg agc aaa cta tcg aaa gga tta taa      720
 Met Lys Leu Glu Thr Ile Ile Leu Ser Lys Leu Ser Lys Gly Leu 
 225                 230                 235





      <210> 680
      <211> 2844
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (1)..(2844)

      <400> 680
  atg ggg cct ctc atg ttc ctg aca cat ttt cgt gga gct ata tgt gct      48
  Met Gly Pro Leu Met Phe Leu Thr His Phe Arg Gly Ala Ile Cys Ala
    1               5                  10                  15

 gtc atc tca gag ggt cca cca tca tcc tca gtg act tca gta cat tat       96
 Val Ile Ser Glu Gly Pro Pro Ser Ser Ser Val Thr Ser Val His Tyr
              20                  25                  30

 atg ggc aat tcc tcc aac aca aag gcc cct cag ttt gac ctc ctc atc      144
 Met Gly Asn Ser Ser Asn Thr Lys Ala Pro Gln Phe Asp Leu Leu Ile
          35                  40                  45

 tcc aat gac ctt cct ctt cac tcc aca act cta gcc ctg gaa aat ctc      192
 Ser Asn Asp Leu Pro Leu His Ser Thr Thr Leu Ala Leu Glu Asn Leu
      50                  55                  60

 ctg gct gcc acc tct tta gtt aca cct gtg aca gag aaa tgt gga ggt      240
 Leu Ala Ala Thr Ser Leu Val Thr Pro Val Thr Glu Lys Cys Gly Gly
  65                  70                  75                  80

 gct cat gag tcc tgc aca cct ttg ctc tcc tcc acg caa gtt cag ctg      288
 Ala His Glu Ser Cys Thr Pro Leu Leu Ser Ser Thr Gln Val Gln Leu
                  85                  90                  95

 acc gtc agc atc ctt ctg acc aag ctc aac ctc agg tct act gcc aga      336
 Thr Val Ser Ile Leu Leu Thr Lys Leu Asn Leu Arg Ser Thr Ala Arg
             100                 105                 110

 cat gtg gcc acg gga cac aga gag atc ata gcc tcc tat gga cct gtt      384
 His Val Ala Thr Gly His Arg Glu Ile Ile Ala Ser Tyr Gly Pro Val
         115                 120                 125

 tat gaa att ccc ctt cac acg cac atg ggg tgg ctc ata tgc aga aaa      432
 Tyr Glu Ile Pro Leu His Thr His Met Gly Trp Leu Ile Cys Arg Lys
     130                 135                 140

 agc act gac aaa atc cag cat ccc ttt atg att aaa act ctc agc aaa      480
 Ser Thr Asp Lys Ile Gln His Pro Phe Met Ile Lys Thr Leu Ser Lys
 145                 150                 155                 160

 att ggc aca gaa ggg act tac ctc aag gga ttc cgg ttc aca atg gat      528
 Ile Gly Thr Glu Gly Thr Tyr Leu Lys Gly Phe Arg Phe Thr Met Asp
                 165                 170                 175

 gct gat aaa gag aaa gat ttg cag aaa ttt ctt aaa aat gtg gat gaa      576
 Ala Asp Lys Glu Lys Asp Leu Gln Lys Phe Leu Lys Asn Val Asp Glu
             180                 185                 190

 atc tcc aat tta att cag gag atg aat tct gat gac cca gtt gtg caa      624
 Ile Ser Asn Leu Ile Gln Glu Met Asn Ser Asp Asp Pro Val Val Gln
         195                 200                 205

 cag aaa gct gtc ctg gag aca gaa aag aga cta ctg ctt atg gag gaa      672
 Gln Lys Ala Val Leu Glu Thr Glu Lys Arg Leu Leu Leu Met Glu Glu
     210                 215                 220

 gac cag gag gag gat gaa tgc agg acc acc ttg aac aag act atg atc      720
 Asp Gln Glu Glu Asp Glu Cys Arg Thr Thr Leu Asn Lys Thr Met Ile
 225                 230                 235                 240

 agt cct cca caa act gct atg aag agt gca gaa gaa ata aac tca gcc      768
 Ser Pro Pro Gln Thr Ala Met Lys Ser Ala Glu Glu Ile Asn Ser Ala
                 245                 250                 255

 cta aaa gaa aaa ggg aat gaa gca ttt gct gaa ggc aat tat gaa aca      816
 Leu Lys Glu Lys Gly Asn Glu Ala Phe Ala Glu Gly Asn Tyr Glu Thr
             260                 265                 270

 gct atc ctg cgc tac agt gag ggt ttg gag aag ctg aag gac atg aaa      864
 Ala Ile Leu Arg Tyr Ser Glu Gly Leu Glu Lys Leu Lys Asp Met Lys
         275                 280                 285

 gtg ctg tac acc aac cga gcc cag gct tat atg aaa ctt gag gac tat      912
 Val Leu Tyr Thr Asn Arg Ala Gln Ala Tyr Met Lys Leu Glu Asp Tyr
     290                 295                 300

 gag aag gca ctg gtg gat tgt gag tgg gct ctc aag tgt gat gaa aaa      960
 Glu Lys Ala Leu Val Asp Cys Glu Trp Ala Leu Lys Cys Asp Glu Lys
 305                 310                 315                 320

 tgc aca aaa gca tat ttt cac atg gga aaa gcc aac ctg gcc ctg aag     1008
 Cys Thr Lys Ala Tyr Phe His Met Gly Lys Ala Asn Leu Ala Leu Lys
                 325                 330                 335

 aac tac agt gtg tct aga gag tgt tat aag aag atc tta gaa ata aac     1056
 Asn Tyr Ser Val Ser Arg Glu Cys Tyr Lys Lys Ile Leu Glu Ile Asn
             340                 345                 350

 ccc aag ctg caa acc cag gtg aaa ggt tac ctg aat caa gta gat ctt     1104
 Pro Lys Leu Gln Thr Gln Val Lys Gly Tyr Leu Asn Gln Val Asp Leu
         355                 360                 365

 cag gaa aaa gca gac ctt caa gaa aag gaa gcc cac gaa ctg ctg gat     1152
 Gln Glu Lys Ala Asp Leu Gln Glu Lys Glu Ala His Glu Leu Leu Asp
     370                 375                 380

 tca gga aag aac aca gcc gtg acc acc aag aac ctc ctg gag acc ctt     1200
 Ser Gly Lys Asn Thr Ala Val Thr Thr Lys Asn Leu Leu Glu Thr Leu
 385                 390                 395                 400

 tcc aag cct gac cag atc ccc ttg ttc tat gct ggg ggg att gag atc     1248
 Ser Lys Pro Asp Gln Ile Pro Leu Phe Tyr Ala Gly Gly Ile Glu Ile
                 405                 410                 415

 ctg act gaa atg ata aat gag tgc aca gaa caa act tta ttc aga atg     1296
 Leu Thr Glu Met Ile Asn Glu Cys Thr Glu Gln Thr Leu Phe Arg Met
             420                 425                 430

 cac aat gga ttt agt atc atc agt gac aac gag gtc ata aga agg tgt     1344
 His Asn Gly Phe Ser Ile Ile Ser Asp Asn Glu Val Ile Arg Arg Cys
         435                 440                 445

 ttt tcc aca gca gga aat gat gca gtt gaa gaa atg gtc tgt gtg tct     1392
 Phe Ser Thr Ala Gly Asn Asp Ala Val Glu Glu Met Val Cys Val Ser
     450                 455                 460

 gtt ctc aag ctc tgg caa gca gtg tgc agc agg aac gag gaa aac cag     1440
 Val Leu Lys Leu Trp Gln Ala Val Cys Ser Arg Asn Glu Glu Asn Gln
 465                 470                 475                 480

 cgt gtg cta gtg ata cac cat gac agg gcc agg ctg ttg gcc gcc ctc     1488
 Arg Val Leu Val Ile His His Asp Arg Ala Arg Leu Leu Ala Ala Leu
                 485                 490                 495

 ttg tcc tcc aag gtc ctg gcc atc cgg cag cag agc ttt gcc ctg ctg     1536
 Leu Ser Ser Lys Val Leu Ala Ile Arg Gln Gln Ser Phe Ala Leu Leu
             500                 505                 510

 ctg cat ctc gcc cag act gag agc gga cgg agc ctg atc atc aac cac     1584
 Leu His Leu Ala Gln Thr Glu Ser Gly Arg Ser Leu Ile Ile Asn His
         515                 520                 525

 ctt gac ctg acc aga tta ttg gaa gcg ctg gtg tca ttt ctt gat ttc     1632
 Leu Asp Leu Thr Arg Leu Leu Glu Ala Leu Val Ser Phe Leu Asp Phe
     530                 535                 540

 tcg gat aag gag gcc aac act gct atg gga ctg ttc aca gac ttg gct     1680
 Ser Asp Lys Glu Ala Asn Thr Ala Met Gly Leu Phe Thr Asp Leu Ala
 545                 550                 555                 560

 ctg gaa gaa agt gag acc cca ggg atg ccc ctg tgt gac atg aag cta     1728
 Leu Glu Glu Ser Glu Thr Pro Gly Met Pro Leu Cys Asp Met Lys Leu
                 565                 570                 575

 tct ggt tgg ttc gtg ggc ctt ttg aag aca gat ccc aag gta agc agc     1776
 Ser Gly Trp Phe Val Gly Leu Leu Lys Thr Asp Pro Lys Val Ser Ser
             580                 585                 590

 tcc tcg gct ctg tgc cag tgc att gcc atc atg gga aac ctc agt gct     1824
 Ser Ser Ala Leu Cys Gln Cys Ile Ala Ile Met Gly Asn Leu Ser Ala
         595                 600                 605

 gag ccc act acc cga aga cac atg gcg gcc tgt gag gaa ttt ggg gat     1872
 Glu Pro Thr Thr Arg Arg His Met Ala Ala Cys Glu Glu Phe Gly Asp
     610                 615                 620

 ggc tgc ttg agc ctc ctg gtt tgg gct gtg gag gtg agc aga agg tgc     1920
 Gly Cys Leu Ser Leu Leu Val Trp Ala Val Glu Val Ser Arg Arg Cys
 625                 630                 635                 640

 ctg tct tta cta aac agc cag gat gga gga atc ctg aca aga gct gct     1968
 Leu Ser Leu Leu Asn Ser Gln Asp Gly Gly Ile Leu Thr Arg Ala Ala
                 645                 650                 655

 ggt gtt ctg agc cgg acc ctt tct tcc tct ctg aaa att gtt gag gag     2016
 Gly Val Leu Ser Arg Thr Leu Ser Ser Ser Leu Lys Ile Val Glu Glu
             660                 665                 670

 gcc ttg cga gca gga gtg gta aag aaa atg atg aaa ttc ctg aag cag     2064
 Ala Leu Arg Ala Gly Val Val Lys Lys Met Met Lys Phe Leu Lys Gln
         675                 680                 685

 gct tcc cag gag agg cag cct gct aat gtt ctt ctt acc aac tcc ctg     2112
 Ala Ser Gln Glu Arg Gln Pro Ala Asn Val Leu Leu Thr Asn Ser Leu
     690                 695                 700

 gaa tgc aca gaa ggt gaa ctg aag gag gct cca cca tgg aag cgg caa     2160
 Glu Cys Thr Glu Gly Glu Leu Lys Glu Ala Pro Pro Trp Lys Arg Gln
 705                 710                 715                 720

 gcc ttt ctc ctg gat cct gtt gca tac cct gca gag ttg agc gtt atg     2208
 Ala Phe Leu Leu Asp Pro Val Ala Tyr Pro Ala Glu Leu Ser Val Met
                 725                 730                 735

 atg aag ctg ctc agc tcg gag gat gag gtt ctg gtg ggc aac gct gcc     2256
 Met Lys Leu Leu Ser Ser Glu Asp Glu Val Leu Val Gly Asn Ala Ala
             740                 745                 750

 ctc tgc ctt ggt aac tgc atg gag gtg ccc aac gtt gcg tct tcc ctg     2304
 Leu Cys Leu Gly Asn Cys Met Glu Val Pro Asn Val Ala Ser Ser Leu
         755                 760                 765

 cta aag acg gac ctt ttg cag gtc ttg tta aag ctt gca ggc agt gac     2352
 Leu Lys Thr Asp Leu Leu Gln Val Leu Leu Lys Leu Ala Gly Ser Asp
     770                 775                 780

 aca cag aag acg gcc gtg cag gtg aac gca ggc att gct ctg ggg aag     2400
 Thr Gln Lys Thr Ala Val Gln Val Asn Ala Gly Ile Ala Leu Gly Lys
 785                 790                 795                 800

 ctg tgc aca gct gag ccc aga ggc aac gct ccc ttc cag ttg ccc cag     2448
 Leu Cys Thr Ala Glu Pro Arg Gly Asn Ala Pro Phe Gln Leu Pro Gln
                 805                 810                 815

 ggt cac tct aaa cca ggg tca cct gtg gac tgc aag tcc cta aag tgc     2496
 Gly His Ser Lys Pro Gly Ser Pro Val Asp Cys Lys Ser Leu Lys Cys
             820                 825                 830

 ctg ccg aga gca gtc atc tcc aat ttg gaa gag agt ctg ctg cac ctg     2544
 Leu Pro Arg Ala Val Ile Ser Asn Leu Glu Glu Ser Leu Leu His Leu
         835                 840                 845

 aag ctc tgt ctc ctc gca ggt aat cag agt ctt ctg gtt caa caa gca     2592
 Lys Leu Cys Leu Leu Ala Gly Asn Gln Ser Leu Leu Val Gln Gln Ala
     850                 855                 860

 gag gag ctg gga ttt tcc atc cta aag agg atg tgg ccg gga tgg aac     2640
 Glu Glu Leu Gly Phe Ser Ile Leu Lys Arg Met Trp Pro Gly Trp Asn
 865                 870                 875                 880

 tcc atc acc atc ctg aag cca cag cag agg tgg cag gta aca gac agt     2688
 Ser Ile Thr Ile Leu Lys Pro Gln Gln Arg Trp Gln Val Thr Asp Ser
                 885                 890                 895

 cca gag ctg ctc act gtc ttc ata cat gac gtg agg acg gtg gtt cca     2736
 Pro Glu Leu Leu Thr Val Phe Ile His Asp Val Arg Thr Val Val Pro
             900                 905                 910

 gtg cgc cgc aag atg agg aaa ctg agg tgc aaa gca gtt aag caa ctg     2784
 Val Arg Arg Lys Met Arg Lys Leu Arg Cys Lys Ala Val Lys Gln Leu
         915                 920                 925

 gtc caa gat cta gac cag gtt gaa gga gaa cag gga gtg tct cta aat     2832
 Val Gln Asp Leu Asp Gln Val Glu Gly Glu Gln Gly Val Ser Leu Asn
     930                 935                 940

 ttc cac agc tga                                                     2844
 Phe His Ser 
 945





      <210> 681
      <211> 4989
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (1)..(4989)

      <400> 681
  atg agc gtg gcc tcc ttc ctg cag ttg cct ctg gct gcc cag gag gga      48
  Met Ser Val Ala Ser Phe Leu Gln Leu Pro Leu Ala Ala Gln Glu Gly
    1               5                  10                  15

 tgt ggt gtt gcc tgg cag gga gtg gag aca gcc agt cct ggt gat ggc       96
 Cys Gly Val Ala Trp Gln Gly Val Glu Thr Ala Ser Pro Gly Asp Gly
              20                  25                  30

 ctg cag gac agg gca gat gtg tgg ggc agt tgg ggg cac ccc ctt ttg      144
 Leu Gln Asp Arg Ala Asp Val Trp Gly Ser Trp Gly His Pro Leu Leu
          35                  40                  45

 gaa ggc act gct gcc agt ggg gcc ggt agc agc ggg tcc tct gag gcc      192
 Glu Gly Thr Ala Ala Ser Gly Ala Gly Ser Ser Gly Ser Ser Glu Ala
      50                  55                  60

 tgc gtc aag aat atc ggg ctg tcg gac gcg tca gtc ttc agg ggc agc      240
 Cys Val Lys Asn Ile Gly Leu Ser Asp Ala Ser Val Phe Arg Gly Ser
  65                  70                  75                  80

 ttt ggg cag cgc gtg tct cct gcg tgc agg agc act gtg aag cct ctg      288
 Phe Gly Gln Arg Val Ser Pro Ala Cys Arg Ser Thr Val Lys Pro Leu
                  85                  90                  95

 ctg att cgc tgg caa gcg gca ctg tcc agg ccc cca gag ctc cct gca      336
 Leu Ile Arg Trp Gln Ala Ala Leu Ser Arg Pro Pro Glu Leu Pro Ala
             100                 105                 110

 gag cca cgt gga gac ttg cag gaa tgc tcc cag ccg cca cct cct tcc      384
 Glu Pro Arg Gly Asp Leu Gln Glu Cys Ser Gln Pro Pro Pro Pro Ser
         115                 120                 125

 agt cca gcc gtg ggc agc ctg gca cca gca gct ttg tcc tgg cag tgg      432
 Ser Pro Ala Val Gly Ser Leu Ala Pro Ala Ala Leu Ser Trp Gln Trp
     130                 135                 140

 cag ccc ctg gag cag ggg atg cat ctg gag ccg tgc cag ccc cag ccg      480
 Gln Pro Leu Glu Gln Gly Met His Leu Glu Pro Cys Gln Pro Gln Pro
 145                 150                 155                 160

 ggc aag ggg gct cag gcc gtg ctc cag gcc gtg gca gtg cac tcc gtg      528
 Gly Lys Gly Ala Gln Ala Val Leu Gln Ala Val Ala Val His Ser Val
                 165                 170                 175

 gag cgt gtc tgc ctg tcc ccc ctc cac ggg tgc aca cag tgc acg tgc      576
 Glu Arg Val Cys Leu Ser Pro Leu His Gly Cys Thr Gln Cys Thr Cys
             180                 185                 190

 cgg aag gac atg gtc aag atc tcc atg gac gtg ttc gtg cgc atc ctg      624
 Arg Lys Asp Met Val Lys Ile Ser Met Asp Val Phe Val Arg Ile Leu
         195                 200                 205

 cag ccc gag cgc tac gag ctg tgg aag cag ggc aag gac ctc acg gtg      672
 Gln Pro Glu Arg Tyr Glu Leu Trp Lys Gln Gly Lys Asp Leu Thr Val
     210                 215                 220

 ctg gac cac acg cgg ccc acg gcg ctc acc agc ccc gag ctg agc tcc      720
 Leu Asp His Thr Arg Pro Thr Ala Leu Thr Ser Pro Glu Leu Ser Ser
 225                 230                 235                 240

 tgg agt gca tcc cgg gcc tcg ctg aag gcc aag ctc ctc cgc agg tct      768
 Trp Ser Ala Ser Arg Ala Ser Leu Lys Ala Lys Leu Leu Arg Arg Ser
                 245                 250                 255

 cac cgg aaa cgg agc cag ccc aag aag ccg aag ccc gaa gac ccc aag      816
 His Arg Lys Arg Ser Gln Pro Lys Lys Pro Lys Pro Glu Asp Pro Lys
             260                 265                 270

 ttc cct ggg gag ggt acg gct ggg gca gcg ctc cta gag gag gct ggg      864
 Phe Pro Gly Glu Gly Thr Ala Gly Ala Ala Leu Leu Glu Glu Ala Gly
         275                 280                 285

 ggc agc gtg aag gag gag gct ggg ccg gag gtt gac ccc gag gag gag      912
 Gly Ser Val Lys Glu Glu Ala Gly Pro Glu Val Asp Pro Glu Glu Glu
     290                 295                 300

 gag gag gag ccg cag cca ctg cca cac ggc cgg gag gcc gag ggc gca      960
 Glu Glu Glu Pro Gln Pro Leu Pro His Gly Arg Glu Ala Glu Gly Ala
 305                 310                 315                 320

 gaa gag gac ggg agg ggc aag ctg cgg cca acc aag gcc aag agc gag     1008
 Glu Glu Asp Gly Arg Gly Lys Leu Arg Pro Thr Lys Ala Lys Ser Glu
                 325                 330                 335

 cgg aag aag aag agc ttc ggc ctg ctg ccc cca cag ctg ccg ccc ccg     1056
 Arg Lys Lys Lys Ser Phe Gly Leu Leu Pro Pro Gln Leu Pro Pro Pro
             340                 345                 350

 cct gct cac ttc ccc tca gag gag gcg ctg tgg ctg cca tcc cca ctg     1104
 Pro Ala His Phe Pro Ser Glu Glu Ala Leu Trp Leu Pro Ser Pro Leu
         355                 360                 365

 gag ccc ccg gtg ctg ggc cca ggc cct gca gcc atg gag gag agc ccc     1152
 Glu Pro Pro Val Leu Gly Pro Gly Pro Ala Ala Met Glu Glu Ser Pro
     370                 375                 380

 ctg ccg gca ccc ctt aat gtc gtg ccc cct gag gtg ccc agt gag gag     1200
 Leu Pro Ala Pro Leu Asn Val Val Pro Pro Glu Val Pro Ser Glu Glu
 385                 390                 395                 400

 cta gag gcc aag cct cgg ccc atc atc ccc atg ctg tac gtg gtg ccg     1248
 Leu Glu Ala Lys Pro Arg Pro Ile Ile Pro Met Leu Tyr Val Val Pro
                 405                 410                 415

 cgg ccg ggc aag gca gcc ttc aac cag gag cac gtg tcc tgc cag cag     1296
 Arg Pro Gly Lys Ala Ala Phe Asn Gln Glu His Val Ser Cys Gln Gln
             420                 425                 430

 gcc ttt gag cac ttt gcc cag aag ggt ccg acc tgg aag gaa cca gtt     1344
 Ala Phe Glu His Phe Ala Gln Lys Gly Pro Thr Trp Lys Glu Pro Val
         435                 440                 445

 tcc ccc atg gag ctg acg ggg cca gag gac ggt gca gcc agc agt ggg     1392
 Ser Pro Met Glu Leu Thr Gly Pro Glu Asp Gly Ala Ala Ser Ser Gly
     450                 455                 460

 gca ggt cgc atg gag acc aaa gcc cgg gcc gga gag ggg cag gca ccg     1440
 Ala Gly Arg Met Glu Thr Lys Ala Arg Ala Gly Glu Gly Gln Ala Pro
 465                 470                 475                 480

 tcc aca ttt tcc aaa ttg aag atg gag atc aag aag agc cgg cgc cat     1488
 Ser Thr Phe Ser Lys Leu Lys Met Glu Ile Lys Lys Ser Arg Arg His
                 485                 490                 495

 ccc ctg ggc cgg ccg ccc acc cgg tcc cca ctg tcg gtg gtg aag cag     1536
 Pro Leu Gly Arg Pro Pro Thr Arg Ser Pro Leu Ser Val Val Lys Gln
             500                 505                 510

 gag gcc tca agt gac gag ggt tgg gct gag gat tgg gcc aca gga gtg     1584
 Glu Ala Ser Ser Asp Glu Gly Trp Ala Glu Asp Trp Ala Thr Gly Val
         515                 520                 525

 ggc acc cca ctt cct ggg gac agc acc cct gtg tcc aca gga gat gca     1632
 Gly Thr Pro Leu Pro Gly Asp Ser Thr Pro Val Ser Thr Gly Asp Ala
     530                 535                 540

 ggg agg gga cgt ggg gag att ggg gtg cgg cag ctg gca atg gag gcc     1680
 Gly Arg Gly Arg Gly Glu Ile Gly Val Arg Gln Leu Ala Met Glu Ala
 545                 550                 555                 560

 att aga gtt caa tgg gaa cag gca aca gag gca tcc cct ttc tcc ggg     1728
 Ile Arg Val Gln Trp Glu Gln Ala Thr Glu Ala Ser Pro Phe Ser Gly
                 565                 570                 575

 gag gaa gat gtg agt gac ccg gac gcc ttg agg ccg ctg ctg tct ctg     1776
 Glu Glu Asp Val Ser Asp Pro Asp Ala Leu Arg Pro Leu Leu Ser Leu
             580                 585                 590

 cag tgg aag aac agg gcg gcc agc ttc cag gcc gag agg aag ttc aac     1824
 Gln Trp Lys Asn Arg Ala Ala Ser Phe Gln Ala Glu Arg Lys Phe Asn
         595                 600                 605

 gca gcg gct gcg cgc acg gag ccc tac tgc gcc atc tgc acg ctc ttc     1872
 Ala Ala Ala Ala Arg Thr Glu Pro Tyr Cys Ala Ile Cys Thr Leu Phe
     610                 615                 620

 tac ccc tac tgc cag gcc cta cag act gag aag gag gca ccc ata gcc     1920
 Tyr Pro Tyr Cys Gln Ala Leu Gln Thr Glu Lys Glu Ala Pro Ile Ala
 625                 630                 635                 640

 tcc ctc gga aag ggc tgc ccg gcc aca tta ccc tcc aaa agc cgt cag     1968
 Ser Leu Gly Lys Gly Cys Pro Ala Thr Leu Pro Ser Lys Ser Arg Gln
                 645                 650                 655

 aag acc cga ccg ctc atc cct gag atg tgc ttc acc tct ggc ggt gag     2016
 Lys Thr Arg Pro Leu Ile Pro Glu Met Cys Phe Thr Ser Gly Gly Glu
             660                 665                 670

 aac acg gag ccg ctg cct gcc aac tcc tac atc ggc gac gac ggg acc     2064
 Asn Thr Glu Pro Leu Pro Ala Asn Ser Tyr Ile Gly Asp Asp Gly Thr
         675                 680                 685

 agc ccc ctg atc gcc tgc ggc aag tgc tgc ctg cag gtc cat gcc agt     2112
 Ser Pro Leu Ile Ala Cys Gly Lys Cys Cys Leu Gln Val His Ala Ser
     690                 695                 700

 tgc tat ggc atc cgt ccc gag ctg gtc aat gaa ggc tgg acg tgt tcc     2160
 Cys Tyr Gly Ile Arg Pro Glu Leu Val Asn Glu Gly Trp Thr Cys Ser
 705                 710                 715                 720

 cgg tgc gcg gcc cac gcc tgg act gcg gag tgc tgc ctg tgc aac ctg     2208
 Arg Cys Ala Ala His Ala Trp Thr Ala Glu Cys Cys Leu Cys Asn Leu
                 725                 730                 735

 cga gga ggt gcg ctg cag atg acc acc gat agg agg tgg atc cac gtg     2256
 Arg Gly Gly Ala Leu Gln Met Thr Thr Asp Arg Arg Trp Ile His Val
             740                 745                 750

 atc tgt gcc atc gca gtc ccc gag gcg cgc ttc ctg aac gtg att gag     2304
 Ile Cys Ala Ile Ala Val Pro Glu Ala Arg Phe Leu Asn Val Ile Glu
         755                 760                 765

 cgc cac cct gtg gac atc agc gcc atc ccc gag cag cgg tgg aag ctg     2352
 Arg His Pro Val Asp Ile Ser Ala Ile Pro Glu Gln Arg Trp Lys Leu
     770                 775                 780

 gct gtt gtg ggt tgc gcc gca gcg gat gtg gga gtg tgg ttg tgg ttt     2400
 Ala Val Val Gly Cys Ala Ala Ala Asp Val Gly Val Trp Leu Trp Phe
 785                 790                 795                 800

 gga gat tct gat gtc att tcc tgt gga tac aga ccc agc agt ggg ctt     2448
 Gly Asp Ser Asp Val Ile Ser Cys Gly Tyr Arg Pro Ser Ser Gly Leu
                 805                 810                 815

 gct gga ccg tcg ggc agc tct gtt ttt agc act gga gga aac tgc tct     2496
 Ala Gly Pro Ser Gly Ser Ser Val Phe Ser Thr Gly Gly Asn Cys Ser
             820                 825                 830

 ccc ttg cgg ctg gac gga ctc cca tcc gca ccc ccc ggg tgc agg gct     2544
 Pro Leu Arg Leu Asp Gly Leu Pro Ser Ala Pro Pro Gly Cys Arg Ala
         835                 840                 845

 ttc ccc ttc ccc tcg tcc tca ctc aca cct acc ttt gac ttt ttt gta     2592
 Phe Pro Phe Pro Ser Ser Ser Leu Thr Pro Thr Phe Asp Phe Phe Val
     850                 855                 860

 gca gcc gcc cta gca gcc gcg gac aca gtg cct ggt gtt gac att cag     2640
 Ala Ala Ala Leu Ala Ala Ala Asp Thr Val Pro Gly Val Asp Ile Gln
 865                 870                 875                 880

 gct tgc gtg gag gtg ggg ctg gaa gca gac aga tca gtc tgg cag gaa     2688
 Ala Cys Val Glu Val Gly Leu Glu Ala Asp Arg Ser Val Trp Gln Glu
                 885                 890                 895

 cgc agc ctc ttc att acc ggt gct tgt aac gat gaa tta aaa atc ctt     2736
 Arg Ser Leu Phe Ile Thr Gly Ala Cys Asn Asp Glu Leu Lys Ile Leu
             900                 905                 910

 tta cac gag gcc cgc ttg tac tgc tta atg ggg ctt tgc aag gag gcg     2784
 Leu His Glu Ala Arg Leu Tyr Cys Leu Met Gly Leu Cys Lys Glu Ala
         915                 920                 925

 gcg gtt aat tcc tgc tcg ccc aac cgc cca gcc acc ttc gcg ggc cac     2832
 Ala Val Asn Ser Cys Ser Pro Asn Arg Pro Ala Thr Phe Ala Gly His
     930                 935                 940

 ggg cag gct gca ggc atg ggg cac tca ctc ctg gtt acc cat ccg tca     2880
 Gly Gln Ala Ala Gly Met Gly His Ser Leu Leu Val Thr His Pro Ser
 945                 950                 955                 960

 gtt tgt ctc cag gac ttc tcc agc cac cgg ctc agg gct cca ggc agt     2928
 Val Cys Leu Gln Asp Phe Ser Ser His Arg Leu Arg Ala Pro Gly Ser
                 965                 970                 975

 cct ggt gag tca ggg ggc tcc ggc tgg ccg ccc gcc tgg gcc aag tta     2976
 Pro Gly Glu Ser Gly Gly Ser Gly Trp Pro Pro Ala Trp Ala Lys Leu
             980                 985                 990

 tca cca cgt tct caa ggc cgt gct gct gag aag ctt ctc acc tac cgg     3024
 Ser Pro Arg Ser Gln Gly Arg Ala Ala Glu Lys Leu Leu Thr Tyr Arg
         995                1000                1005

 ctg ggc agg ttc ctg gca gca ggc aaa agc acc ggg agc tcc ctg gag     3072
 Leu Gly Arg Phe Leu Ala Ala Gly Lys Ser Thr Gly Ser Ser Leu Glu
    1010                1015                1020

 gat ctg gga ggc cgt ggt gct ctg cag acc tct gaa gcc cac ccg cgt     3120
 Asp Leu Gly Gly Arg Gly Ala Leu Gln Thr Ser Glu Ala His Pro Arg
1025                1030                1035                1040

 cgt cct cac agc cct gtg gcc tcc gag gaa gga cac cga gcc ggg aac     3168
 Arg Pro His Ser Pro Val Ala Ser Glu Glu Gly His Arg Ala Gly Asn
                1045                1050                1055

 ttc gaa cca aac acc agt gcc tgg gcc ctt cca ggc ccc cca cgg gcc     3216
 Phe Glu Pro Asn Thr Ser Ala Trp Ala Leu Pro Gly Pro Pro Arg Ala
            1060                1065                1070

 gta gac cct gac tcc ccg gca cac act ggc ctg ggc cag gcc agc act     3264
 Val Asp Pro Asp Ser Pro Ala His Thr Gly Leu Gly Gln Ala Ser Thr
        1075                1080                1085

 gga tgt ggg tct tca aac tgc ggc tcc cag gaa ggg agg gca cat ctc     3312
 Gly Cys Gly Ser Ser Asn Cys Gly Ser Gln Glu Gly Arg Ala His Leu
    1090                1095                1100

 tgt cgc cac gtg gtt cct ctg gct gag cga cac cac aaa tgc gtg tac     3360
 Cys Arg His Val Val Pro Leu Ala Glu Arg His His Lys Cys Val Tyr
1105                1110                1115                1120

 tgc cgg aag cgg atg aag aag gtg tca ggt gcc tgt atc cag tgc tcc     3408
 Cys Arg Lys Arg Met Lys Lys Val Ser Gly Ala Cys Ile Gln Cys Ser
                1125                1130                1135

 tac gag cac tgc tcc acg tcc ttc cac gtg acc tgc gcc cac gcc gca     3456
 Tyr Glu His Cys Ser Thr Ser Phe His Val Thr Cys Ala His Ala Ala
            1140                1145                1150

 ggc gtg ctc atg gag ccg gac gac tgg ccc tat gtg gtc tcc atc acc     3504
 Gly Val Leu Met Glu Pro Asp Asp Trp Pro Tyr Val Val Ser Ile Thr
        1155                1160                1165

 tgc ctc aag cac aag tcg ggg ggt cac gct gtc caa ctc ctg agg gcc     3552
 Cys Leu Lys His Lys Ser Gly Gly His Ala Val Gln Leu Leu Arg Ala
    1170                1175                1180

 gtg tcc cta ggc cag gtg gtc atc acc aag aac cgc aac ggg ctg tac     3600
 Val Ser Leu Gly Gln Val Val Ile Thr Lys Asn Arg Asn Gly Leu Tyr
1185                1190                1195                1200

 tac cgc tgt cgc gtc atc ggt gcc gcc tcg cag acc tgc tac gaa gtg     3648
 Tyr Arg Cys Arg Val Ile Gly Ala Ala Ser Gln Thr Cys Tyr Glu Val
                1205                1210                1215

 aac ttc gac gat ggc tcc tac agc gac aac ctg tac cct gag agc atc     3696
 Asn Phe Asp Asp Gly Ser Tyr Ser Asp Asn Leu Tyr Pro Glu Ser Ile
            1220                1225                1230

 acg agt agg gac tgt gtc cag ctg gga ccc cct tcc gag ggg gag ctg     3744
 Thr Ser Arg Asp Cys Val Gln Leu Gly Pro Pro Ser Glu Gly Glu Leu
        1235                1240                1245

 gtg gag ctc cgg tgg act gac ggc aac ctc tac aag gcc aag ttc atc     3792
 Val Glu Leu Arg Trp Thr Asp Gly Asn Leu Tyr Lys Ala Lys Phe Ile
    1250                1255                1260

 tcc tcc gtc acc agc cac atc tac cag gcc ggc ccc gcc cgg tca cca     3840
 Ser Ser Val Thr Ser His Ile Tyr Gln Ala Gly Pro Ala Arg Ser Pro
1265                1270                1275                1280

 ctc tcg gac ctg tca ctg agc atc cag gac ccc cac ccc cgg ccg tgc     3888
 Leu Ser Asp Leu Ser Leu Ser Ile Gln Asp Pro His Pro Arg Pro Cys
                1285                1290                1295

 agg ccg acc ccg ccc agt cac cac tct caa cct gtc act gag cat cca     3936
 Arg Pro Thr Pro Pro Ser His His Ser Gln Pro Val Thr Glu His Pro
            1300                1305                1310

 gga ccg cct tgc cat gca ggc cgg ccc cgc ccg gtc act gct ctc gga     3984
 Gly Pro Pro Cys His Ala Gly Arg Pro Arg Pro Val Thr Ala Leu Gly
        1315                1320                1325

 cct gtc act gag cat cca gga ccc ccc ccg ctc cgc cgt gca ggc cgg     4032
 Pro Val Thr Glu His Pro Gly Pro Pro Pro Leu Arg Arg Ala Gly Arg
    1330                1335                1340

 ccc cgc cca gtc acc act ctc gac ctg tca ctg agc atc cag gac ctc     4080
 Pro Arg Pro Val Thr Thr Leu Asp Leu Ser Leu Ser Ile Gln Asp Leu
1345                1350                1355                1360

 ctt gcc atg cag gct ggc ccc acc cgg tca cca ctc tcg gac ctt gca     4128
 Leu Ala Met Gln Ala Gly Pro Thr Arg Ser Pro Leu Ser Asp Leu Ala
                1365                1370                1375

 ggg tct tcc ctg ctc ctt gag aag ggg gtg gtt tcg ggg aca agc cat     4176
 Gly Ser Ser Leu Leu Leu Glu Lys Gly Val Val Ser Gly Thr Ser His
            1380                1385                1390

 ccc cat ggc cag ccc tgt ggg agc tac cac caa tct cca gac act gtc     4224
 Pro His Gly Gln Pro Cys Gly Ser Tyr His Gln Ser Pro Asp Thr Val
        1395                1400                1405

 act tct gct cag ctc cag cct tcc ctg ggg gga ggc tca ggc agc tcc     4272
 Thr Ser Ala Gln Leu Gln Pro Ser Leu Gly Gly Gly Ser Gly Ser Ser
    1410                1415                1420

 ttg gac ttc ctg att gtg tta ggc tta gac caa ggg caa ggt cga ttt     4320
 Leu Asp Phe Leu Ile Val Leu Gly Leu Asp Gln Gly Gln Gly Arg Phe
1425                1430                1435                1440

 gca ccc ctt agc cca tcc cag gca gca gca aaa gag aat aat ccc tgc     4368
 Ala Pro Leu Ser Pro Ser Gln Ala Ala Ala Lys Glu Asn Asn Pro Cys
                1445                1450                1455

 tca gct cac ctg gca gct ctt ctc tca ggt tat gag ttt cag tgc cag     4416
 Ser Ala His Leu Ala Ala Leu Leu Ser Gly Tyr Glu Phe Gln Cys Gln
            1460                1465                1470

 gcc cct gag agc cac atc ccc ctg cag gtg gag ttt gag gac ggg tcc     4464
 Ala Pro Glu Ser His Ile Pro Leu Gln Val Glu Phe Glu Asp Gly Ser
        1475                1480                1485

 cag ctg acg gtg aag cgt ggg gac atc ttc acc ctg gag gag gag ctg     4512
 Gln Leu Thr Val Lys Arg Gly Asp Ile Phe Thr Leu Glu Glu Glu Leu
    1490                1495                1500

 ccc aag agg gtc cgc tct cgg ctg tca ctg agc acg ggg gca ccg cag     4560
 Pro Lys Arg Val Arg Ser Arg Leu Ser Leu Ser Thr Gly Ala Pro Gln
1505                1510                1515                1520

 gag ccc gcc ttc tcg ggg gag gag gcc aag gcc gcc aag cgc ccg cgt     4608
 Glu Pro Ala Phe Ser Gly Glu Glu Ala Lys Ala Ala Lys Arg Pro Arg
                1525                1530                1535

 gtg ggc acc ccg ctt gcc acg gag gac tcc ggg cgg agc cag gac tac     4656
 Val Gly Thr Pro Leu Ala Thr Glu Asp Ser Gly Arg Ser Gln Asp Tyr
            1540                1545                1550

 gtg gcc ttc gtg gag agc ctc ctg cag aag gag tgt cca cct gcc tgc     4704
 Val Ala Phe Val Glu Ser Leu Leu Gln Lys Glu Cys Pro Pro Ala Cys
        1555                1560                1565

 tgt gcc gag ggc ttg tgt cct gaa cag agg gtg ccc ttg aca aaa aag     4752
 Cys Ala Glu Gly Leu Cys Pro Glu Gln Arg Val Pro Leu Thr Lys Lys
    1570                1575                1580

 ctt cat cca cct act gcc ccc agc acc gac tct cct ttc tgg ggc cct     4800
 Leu His Pro Pro Thr Ala Pro Ser Thr Asp Ser Pro Phe Trp Gly Pro
1585                1590                1595                1600

 ctc gcc tcc agc atc ctc tca aca cca cca gga ctc agt tcc cct gtg     4848
 Leu Ala Ser Ser Ile Leu Ser Thr Pro Pro Gly Leu Ser Ser Pro Val
                1605                1610                1615

 tgc tgc agg gac agc ccc tca gtg ccc agg tcc acc ttg gct ctc aaa     4896
 Cys Cys Arg Asp Ser Pro Ser Val Pro Arg Ser Thr Leu Ala Leu Lys
            1620                1625                1630

 ggc ttc cag tta gat gga cag tgg gca gcc aac tgc ccc cgc tgc cac     4944
 Gly Phe Gln Leu Asp Gly Gln Trp Ala Ala Asn Cys Pro Arg Cys His
        1635                1640                1645

 ccg cag gag cgg gtg gaa aaa gga ggc ttt gac cag gga ctt tga         4989
 Pro Gln Glu Arg Val Glu Lys Gly Gly Phe Asp Gln Gly Leu 
    1650                1655                1660





      <210> 682
      <211> 2613
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (1)..(2613)

      <400> 682
  atg gcg ggt ctg acg gcg gcg gcc ccg cgg ccc gga gtc ctc ctg ctc      48
  Met Ala Gly Leu Thr Ala Ala Ala Pro Arg Pro Gly Val Leu Leu Leu
    1               5                  10                  15

 ctg ctg tcc atc ctc cac ccc tct cgg cct gga ggt aag gac ccc tcg       96
 Leu Leu Ser Ile Leu His Pro Ser Arg Pro Gly Gly Lys Asp Pro Ser
              20                  25                  30

 ccc ctg tcc cca gcg ctg ccc aca gct gcg ggc cct ttg ggc cag ggg      144
 Pro Leu Ser Pro Ala Leu Pro Thr Ala Ala Gly Pro Leu Gly Gln Gly
          35                  40                  45

 gat cag agc atc ctg ggg gag ggc cca gcg gga acc cct ggg tct gga      192
 Asp Gln Ser Ile Leu Gly Glu Gly Pro Ala Gly Thr Pro Gly Ser Gly
      50                  55                  60

 gac acc aca gtc tgc aca cct gtg gac aca gct ggg gtg cac acc agc      240
 Asp Thr Thr Val Cys Thr Pro Val Asp Thr Ala Gly Val His Thr Ser
  65                  70                  75                  80

 cct ggg gac agg gaa cct ggg ctt gat acc agc tca acc gca ggg tcc      288
 Pro Gly Asp Arg Glu Pro Gly Leu Asp Thr Ser Ser Thr Ala Gly Ser
                  85                  90                  95

 ctg ggg cca ttc ctg gtg gag ttc ctg gag gag tct ttt atc cag gta      336
 Leu Gly Pro Phe Leu Val Glu Phe Leu Glu Glu Ser Phe Ile Gln Val
             100                 105                 110

 acg tac atg aaa ctt cca cac acc cag gtc atg cgg atg atg ctg atg      384
 Thr Tyr Met Lys Leu Pro His Thr Gln Val Met Arg Met Met Leu Met
         115                 120                 125

 tcc ata ata gat gca cat ttt gac act aca gaa ggg gct ggt ctc gga      432
 Ser Ile Ile Asp Ala His Phe Asp Thr Thr Glu Gly Ala Gly Leu Gly
     130                 135                 140

 gcc ctt gga gga gga gcg ctg ggg cct gga ggc aaa cct ctt aag cca      480
 Ala Leu Gly Gly Gly Ala Leu Gly Pro Gly Gly Lys Pro Leu Lys Pro
 145                 150                 155                 160

 gat gct aga atc ctt ggg gca ttt ggg gca gtt ccc gga ggg ctt gcg      528
 Asp Ala Arg Ile Leu Gly Ala Phe Gly Ala Val Pro Gly Gly Leu Ala
                 165                 170                 175

 ggt gct ggc ctt ggg gca ggg ctc ggc gcc ttc ccc gca gtt acc ttt      576
 Gly Ala Gly Leu Gly Ala Gly Leu Gly Ala Phe Pro Ala Val Thr Phe
             180                 185                 190

 ccg ggg gct ctg gtg cct ggt gga gtg gct gac gct gct gca gcc tat      624
 Pro Gly Ala Leu Val Pro Gly Gly Val Ala Asp Ala Ala Ala Ala Tyr
         195                 200                 205

 aaa gct gct aag gct ggt gtg ggg ctg cca ggt gta tac cca ggt ggc      672
 Lys Ala Ala Lys Ala Gly Val Gly Leu Pro Gly Val Tyr Pro Gly Gly
     210                 215                 220

 gtg ctc cca gga gct cgg ttc ccc ggt gtg ggg gtg ctc cct gga gtt      720
 Val Leu Pro Gly Ala Arg Phe Pro Gly Val Gly Val Leu Pro Gly Val
 225                 230                 235                 240

 ccc act gga gca gga gtt aag ccc aag gct cca ggt gta ggt gga gct      768
 Pro Thr Gly Ala Gly Val Lys Pro Lys Ala Pro Gly Val Gly Gly Ala
                 245                 250                 255

 ttt gct gga atc cca gga gtt gga ccc ttt ggg gga ccg caa cct gga      816
 Phe Ala Gly Ile Pro Gly Val Gly Pro Phe Gly Gly Pro Gln Pro Gly
             260                 265                 270

 gtc cca ctg ggg tat ccc atc aag gcc ccc aag ctg cct ggt ggc tat      864
 Val Pro Leu Gly Tyr Pro Ile Lys Ala Pro Lys Leu Pro Gly Gly Tyr
         275                 280                 285

 gga ctg ccc tac acc aca ggg aaa ctg ccc tat ggc tat ggg ccc gga      912
 Gly Leu Pro Tyr Thr Thr Gly Lys Leu Pro Tyr Gly Tyr Gly Pro Gly
     290                 295                 300

 gga gtg gct ggt gca gcg ggc aag gct ggt tac cca aca ggg aca ggg      960
 Gly Val Ala Gly Ala Ala Gly Lys Ala Gly Tyr Pro Thr Gly Thr Gly
 305                 310                 315                 320

 gtt ggc ccc cag gca gca gca gca gcg gca gct aaa gca gca gca aag     1008
 Val Gly Pro Gln Ala Ala Ala Ala Ala Ala Ala Lys Ala Ala Ala Lys
                 325                 330                 335

 ttc ggt gct gga gca gcc gga gtc ctc cct ggt gtt gga ggg gct ggt     1056
 Phe Gly Ala Gly Ala Ala Gly Val Leu Pro Gly Val Gly Gly Ala Gly
             340                 345                 350

 gtt cct ggc gtg cct ggg gca att cct gga att gga ggc atc gca ggc     1104
 Val Pro Gly Val Pro Gly Ala Ile Pro Gly Ile Gly Gly Ile Ala Gly
         355                 360                 365

 gtt ggg act cca gct gca gct gca gct gca gca gca gcc gct aag gca     1152
 Val Gly Thr Pro Ala Ala Ala Ala Ala Ala Ala Ala Ala Ala Lys Ala
     370                 375                 380

 gcc aag tat gga gct gct gca ggc tta gtg cct ggt ggg cca ggc ttt     1200
 Ala Lys Tyr Gly Ala Ala Ala Gly Leu Val Pro Gly Gly Pro Gly Phe
 385                 390                 395                 400

 ggc ccg gga gta gtt ggt gtc cca gga gct ggc gtt cca ggt gtt ggt     1248
 Gly Pro Gly Val Val Gly Val Pro Gly Ala Gly Val Pro Gly Val Gly
                 405                 410                 415

 gtc cca gga gct ggg att cca gtt gtc cca ggt gct ggg atc cca ggt     1296
 Val Pro Gly Ala Gly Ile Pro Val Val Pro Gly Ala Gly Ile Pro Gly
             420                 425                 430

 gct gcg gtt cca ggg gtt gtg tca cca gaa gca gct gct aag gca gct     1344
 Ala Ala Val Pro Gly Val Val Ser Pro Glu Ala Ala Ala Lys Ala Ala
         435                 440                 445

 gca aag gca gcc aaa tac ggg gcc agg ccc gga gtc gga gtt gga ggc     1392
 Ala Lys Ala Ala Lys Tyr Gly Ala Arg Pro Gly Val Gly Val Gly Gly
     450                 455                 460

 att cct act tac ggg gtt gga gct ggg ggc ttt ccc ggc ttt ggt gtc     1440
 Ile Pro Thr Tyr Gly Val Gly Ala Gly Gly Phe Pro Gly Phe Gly Val
 465                 470                 475                 480

 gga gtc gga ggt atc cct gga gtc gca ggt gtc cct ggt gtc gga ggt     1488
 Gly Val Gly Gly Ile Pro Gly Val Ala Gly Val Pro Gly Val Gly Gly
                 485                 490                 495

 gtt ccc gga gtc gga ggt gtc ccg gga gtt ggc att tcc ccc gaa gct     1536
 Val Pro Gly Val Gly Gly Val Pro Gly Val Gly Ile Ser Pro Glu Ala
             500                 505                 510

 cag gca gca gct gcc gcc aag gct gcc aag tac gga gtg ggg acc cca     1584
 Gln Ala Ala Ala Ala Ala Lys Ala Ala Lys Tyr Gly Val Gly Thr Pro
         515                 520                 525

 gca gct gca gct gct aaa gca gcc gcc aaa gcc gcc cag ttt ggg tta     1632
 Ala Ala Ala Ala Ala Lys Ala Ala Ala Lys Ala Ala Gln Phe Gly Leu
     530                 535                 540

 gtt cct ggt gtc ggc gtg gct cct gga gtt ggc gtg gct cct ggt gtc     1680
 Val Pro Gly Val Gly Val Ala Pro Gly Val Gly Val Ala Pro Gly Val
 545                 550                 555                 560

 ggt gtg gct cct gga gtt ggc ttg gct cct gga gtt ggc gtg gct cct     1728
 Gly Val Ala Pro Gly Val Gly Leu Ala Pro Gly Val Gly Val Ala Pro
                 565                 570                 575

 gga gtt ggt gtg gct cct ggc gtt ggc gtg gct ccc ggc att ggc cct     1776
 Gly Val Gly Val Ala Pro Gly Val Gly Val Ala Pro Gly Ile Gly Pro
             580                 585                 590

 ggt gga gtt gca gct gca gca aaa tcc gct gcc aag gtg gct gcc aaa     1824
 Gly Gly Val Ala Ala Ala Ala Lys Ser Ala Ala Lys Val Ala Ala Lys
         595                 600                 605

 gcc cag ctc cga gct gca gct ggg ctt ggt gct ggc atc cct gga ctt     1872
 Ala Gln Leu Arg Ala Ala Ala Gly Leu Gly Ala Gly Ile Pro Gly Leu
     610                 615                 620

 gga gtt ggt gtc ggc gtc cct gga ctt gga gtt ggt gct ggt gtt cct     1920
 Gly Val Gly Val Gly Val Pro Gly Leu Gly Val Gly Ala Gly Val Pro
 625                 630                 635                 640

 gga ctt gga gtt ggt gct ggt gtt cct ggc ttc ggg gca gta cct gga     1968
 Gly Leu Gly Val Gly Ala Gly Val Pro Gly Phe Gly Ala Val Pro Gly
                 645                 650                 655

 gcc ctg gct gcc gct aaa gca gcc aaa tat gga ccg ctc cca cca cga     2016
 Ala Leu Ala Ala Ala Lys Ala Ala Lys Tyr Gly Pro Leu Pro Pro Arg
             660                 665                 670

 gcc agc cca gag gac gtg gca gtc cca cag cct ctg cac ttg gcg ctc     2064
 Ala Ser Pro Glu Asp Val Ala Val Pro Gln Pro Leu His Leu Ala Leu
         675                 680                 685

 tgg cag ccc tgc ctg gcc aga ccc acg ctg tct gta gcc cct gaa ttc     2112
 Trp Gln Pro Cys Leu Ala Arg Pro Thr Leu Ser Val Ala Pro Glu Phe
     690                 695                 700

 ctg gcc tcc tgt gag cag cgt tgg tgg gag gtg gaa gac tcc ccc agg     2160
 Leu Ala Ser Cys Glu Gln Arg Trp Trp Glu Val Glu Asp Ser Pro Arg
 705                 710                 715                 720

 gat cca cca acc agc cgg gca gga gca gca gtg cct ggg gtc ctt gga     2208
 Asp Pro Pro Thr Ser Arg Ala Gly Ala Ala Val Pro Gly Val Leu Gly
                 725                 730                 735

 ggg ctc ggg gct ctc ggt gga gta ggc atc cca ggc ggt gtg gtg gga     2256
 Gly Leu Gly Ala Leu Gly Gly Val Gly Ile Pro Gly Gly Val Val Gly
             740                 745                 750

 gcc gga ccc gcc gcc gcc gct gcc gca gcc aaa gct gct gcc aaa gcc     2304
 Ala Gly Pro Ala Ala Ala Ala Ala Ala Ala Lys Ala Ala Ala Lys Ala
         755                 760                 765

 gcc cag ttt ggt gag cac tgg gtg gag gtg gga gct gcc gcc agg ccc     2352
 Ala Gln Phe Gly Glu His Trp Val Glu Val Gly Ala Ala Ala Arg Pro
     770                 775                 780

 cca ggc ccc cag ggt ata cct cca gct gca gcc gct aaa gca gct aaa     2400
 Pro Gly Pro Gln Gly Ile Pro Pro Ala Ala Ala Ala Lys Ala Ala Lys
 785                 790                 795                 800

 tac ggt gct gct ggc ctt gga ggt gtc cta ggg ggt gcc ggg cag ttc     2448
 Tyr Gly Ala Ala Gly Leu Gly Gly Val Leu Gly Gly Ala Gly Gln Phe
                 805                 810                 815

 cca ctt gga gga gtg gca gca aga cct ggc ttc gga ttg tct ccc att     2496
 Pro Leu Gly Gly Val Ala Ala Arg Pro Gly Phe Gly Leu Ser Pro Ile
             820                 825                 830

 ttc cca gga agc gag ttg ccc gtg tgt gca agc tgc ggc cag agg atc     2544
 Phe Pro Gly Ser Glu Leu Pro Val Cys Ala Ser Cys Gly Gln Arg Ile
         835                 840                 845

 tat gat ggc cag tac ctc cag gcc ctg aac gcg gac tgg cac gca gac     2592
 Tyr Asp Gly Gln Tyr Leu Gln Ala Leu Asn Ala Asp Trp His Ala Asp
     850                 855                 860

 tgc ttc agg aat aac gtc taa                                         2613
 Cys Phe Arg Asn Asn Val 
 865                 870





      <210> 683
      <211> 777
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (1)..(777)

      <400> 683
  atg acc ata ctg ccc aag gta att tat aga ttc agt gcc atc ccc atc      48
  Met Thr Ile Leu Pro Lys Val Ile Tyr Arg Phe Ser Ala Ile Pro Ile
    1               5                  10                  15

 aag cta cca atg act ttc ttc aca gaa ttg gaa aaa act act tta aag       96
 Lys Leu Pro Met Thr Phe Phe Thr Glu Leu Glu Lys Thr Thr Leu Lys
              20                  25                  30

 ttc gta tgg aac caa aaa aga gcc tgc atc acc aag tca atc cta agc      144
 Phe Val Trp Asn Gln Lys Arg Ala Cys Ile Thr Lys Ser Ile Leu Ser
          35                  40                  45

 caa aag aac aaa gct gga ggc atc atg cta cct gac gtc aaa cta tac      192
 Gln Lys Asn Lys Ala Gly Gly Ile Met Leu Pro Asp Val Lys Leu Tyr
      50                  55                  60

 tat aag gct aca gta acc aaa aca gca tgg ttc ttg ggc ctt cag tct      240
 Tyr Lys Ala Thr Val Thr Lys Thr Ala Trp Phe Leu Gly Leu Gln Ser
  65                  70                  75                  80

 cag att ggg aat tat cct cct act gcc ctc aga ctc aaa ccg ggg ctt      288
 Gln Ile Gly Asn Tyr Pro Pro Thr Ala Leu Arg Leu Lys Pro Gly Leu
                  85                  90                  95

 aca tca tca gct cct ctg gtt ctt ggg cct ttg gac tta cag gga att      336
 Thr Ser Ser Ala Pro Leu Val Leu Gly Pro Leu Asp Leu Gln Gly Ile
             100                 105                 110

 aca cca cca acc ctc ctc gtt ctc cag att gtg gaa cag atg att tgg      384
 Thr Pro Pro Thr Leu Leu Val Leu Gln Ile Val Glu Gln Met Ile Trp
         115                 120                 125

 gtg ttg gtt aaa caa tgg cca acc agt gtt cta cat ctc tct gac cat      432
 Val Leu Val Lys Gln Trp Pro Thr Ser Val Leu His Leu Ser Asp His
     130                 135                 140

 gac aat tgg ttc atg ttt ggg cac aag act cac cag cta ata aag ggt      480
 Asp Asn Trp Phe Met Phe Gly His Lys Thr His Gln Leu Ile Lys Gly
 145                 150                 155                 160

 tgt gac ttc tat ttc tct gcc agg gat ggc ttc ggg ctg gtg gta gtt      528
 Cys Asp Phe Tyr Phe Ser Ala Arg Asp Gly Phe Gly Leu Val Val Val
                 165                 170                 175

 ttt aga tca ggc ctt act cca tgc gtg aag gtg aac aat aca gaa ggc      576
 Phe Arg Ser Gly Leu Thr Pro Cys Val Lys Val Asn Asn Thr Glu Gly
             180                 185                 190

 aca gca caa agt gaa ggt caa tca gca cat aat tat agg aac atc gct      624
 Thr Ala Gln Ser Glu Gly Gln Ser Ala His Asn Tyr Arg Asn Ile Ala
         195                 200                 205

 gtg ttg aaa gca gac ttc att acc ctt tgt gag tgc tac ctg ata ttg      672
 Val Leu Lys Ala Asp Phe Ile Thr Leu Cys Glu Cys Tyr Leu Ile Leu
     210                 215                 220

 act gag gac tca gaa gaa gaa aaa agc ttc atg cac cct gca gat ttg      720
 Thr Glu Asp Ser Glu Glu Glu Lys Ser Phe Met His Pro Ala Asp Leu
 225                 230                 235                 240

 cag tgc aac gca ctg tca ttc ctg tgg agg atg tac gag aac ttt ggt      768
 Gln Cys Asn Ala Leu Ser Phe Leu Trp Arg Met Tyr Glu Asn Phe Gly
                 245                 250                 255

 cga aaa taa                                                          777
 Arg Lys 






      <210> 684
      <211> 1056
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (1)..(1056)

      <400> 684
  atg cag ggc cct gcc tgg ctt ctg acc cag gtg acg gtg gca gtg gta      48
  Met Gln Gly Pro Ala Trp Leu Leu Thr Gln Val Thr Val Ala Val Val
    1               5                  10                  15

 acg ggc agt ctg ttt aag ctg att ctt ttc tgt tcc atg gtc ttt cca       96
 Thr Gly Ser Leu Phe Lys Leu Ile Leu Phe Cys Ser Met Val Phe Pro
              20                  25                  30

 agt tca agg ttc tca tct cag tcc cct cac act ctt tca ggg tct gtt      144
 Ser Ser Arg Phe Ser Ser Gln Ser Pro His Thr Leu Ser Gly Ser Val
          35                  40                  45

 tca ggt ctt gtc cct tca acc ttc cct cac ctt ccc tgg ccc agc ctg      192
 Ser Gly Leu Val Pro Ser Thr Phe Pro His Leu Pro Trp Pro Ser Leu
      50                  55                  60

 gag gca gca ggg gaa ggg acc ttg gca gtt gct gta gca gag ggc ttt      240
 Glu Ala Ala Gly Glu Gly Thr Leu Ala Val Ala Val Ala Glu Gly Phe
  65                  70                  75                  80

 tca ccg gtc ttt tgg aac tcc acc cca gag aaa tgc aga gcc act acc      288
 Ser Pro Val Phe Trp Asn Ser Thr Pro Glu Lys Cys Arg Ala Thr Thr
                  85                  90                  95

 aat tgg tgc aat cag ccc ggg ctt aca att tat gtc cag cca gag caa      336
 Asn Trp Cys Asn Gln Pro Gly Leu Thr Ile Tyr Val Gln Pro Glu Gln
             100                 105                 110

 aag cac aca gcc gaa tat gct gca aac ata act aaa agt gtg ttt gat      384
 Lys His Thr Ala Glu Tyr Ala Ala Asn Ile Thr Lys Ser Val Phe Asp
         115                 120                 125

 tat ttt gaa gaa tac ttt gct atg aat tat tct ctt cct aaa tta gat      432
 Tyr Phe Glu Glu Tyr Phe Ala Met Asn Tyr Ser Leu Pro Lys Leu Asp
     130                 135                 140

 aaa atc gct att cca gat ttt ggc act ggt gcc atg gag aac tgg gga      480
 Lys Ile Ala Ile Pro Asp Phe Gly Thr Gly Ala Met Glu Asn Trp Gly
 145                 150                 155                 160

 ctc atc acg tac aga gaa acg aac ctg ctt tat gac cct aag gaa tca      528
 Leu Ile Thr Tyr Arg Glu Thr Asn Leu Leu Tyr Asp Pro Lys Glu Ser
                 165                 170                 175

 gcc tca tca aac caa cag agg gtg gcc act gtg gtt gcc cat gaa ctt      576
 Ala Ser Ser Asn Gln Gln Arg Val Ala Thr Val Val Ala His Glu Leu
             180                 185                 190

 gtg cat cag tgg ttt gga aat att gtg acc atg gac tgg tgg gaa gac      624
 Val His Gln Trp Phe Gly Asn Ile Val Thr Met Asp Trp Trp Glu Asp
         195                 200                 205

 ttg tgg cta aat gaa gga ttt gct tct ttc ttt gag ttt ctg gga gta      672
 Leu Trp Leu Asn Glu Gly Phe Ala Ser Phe Phe Glu Phe Leu Gly Val
     210                 215                 220

 aac cat gca gaa aca gac tgg caa atg cgt gac caa atg tta ctt gaa      720
 Asn His Ala Glu Thr Asp Trp Gln Met Arg Asp Gln Met Leu Leu Glu
 225                 230                 235                 240

 gat gta tta cct gtt caa gag gat gat tct ttg atg tct tcg cat cca      768
 Asp Val Leu Pro Val Gln Glu Asp Asp Ser Leu Met Ser Ser His Pro
                 245                 250                 255

 att att gtg act gtg aca acc cct gat gaa ata aca tct gtt ttt gat      816
 Ile Ile Val Thr Val Thr Thr Pro Asp Glu Ile Thr Ser Val Phe Asp
             260                 265                 270

 gga ata tcc tat agc aag atg tac ttg gaa aaa tac caa ttc aag aat      864
 Gly Ile Ser Tyr Ser Lys Met Tyr Leu Glu Lys Tyr Gln Phe Lys Asn
         275                 280                 285

 gca aaa act tct gat ttt tgg gca gca ctg gaa gag gca agt agg cta      912
 Ala Lys Thr Ser Asp Phe Trp Ala Ala Leu Glu Glu Ala Ser Arg Leu
     290                 295                 300

 cca gtg aaa gaa gta atg gac acc tgg acc aga cag atg ggt tat cct      960
 Pro Val Lys Glu Val Met Asp Thr Trp Thr Arg Gln Met Gly Tyr Pro
 305                 310                 315                 320

 gtg ctt aac gtg aac ggt gtc aag aac atc aca cag aaa cgc ttt ttg     1008
 Val Leu Asn Val Asn Gly Val Lys Asn Ile Thr Gln Lys Arg Phe Leu
                 325                 330                 335

 ttg gac cca aga gct aac cct tct cag ccc cct tca gat ctt ggg taa     1056
 Leu Asp Pro Arg Ala Asn Pro Ser Gln Pro Pro Ser Asp Leu Gly 
             340                 345                 350





      <210> 685
      <211> 1566
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (1)..(1566)

      <400> 685
  atg caa gcg ctg tgt ctt ttc aac ctg ttc ttc aac agt gga agc agc      48
  Met Gln Ala Leu Cys Leu Phe Asn Leu Phe Phe Asn Ser Gly Ser Ser
    1               5                  10                  15

 agg att cca gca ctg tat aat aac tgt cag aaa caa ttt ctg ctc tgt       96
 Arg Ile Pro Ala Leu Tyr Asn Asn Cys Gln Lys Gln Phe Leu Leu Cys
              20                  25                  30

 aag aga ggg gga aag aag aga atc agc tac aaa aga aat tac ctc atg      144
 Lys Arg Gly Gly Lys Lys Arg Ile Ser Tyr Lys Arg Asn Tyr Leu Met
          35                  40                  45

 gag gag cat ctt gaa gga cta tgt tct aat gaa ttc acc tgg gaa aat      192
 Glu Glu His Leu Glu Gly Leu Cys Ser Asn Glu Phe Thr Trp Glu Asn
      50                  55                  60

 tct act att atg act gat agt caa atg tta atg cat aga gaa gaa cct      240
 Ser Thr Ile Met Thr Asp Ser Gln Met Leu Met His Arg Glu Glu Pro
  65                  70                  75                  80

 gga agc tta cca aat att cct att tta agt atc gtc ttc acc aac aac      288
 Gly Ser Leu Pro Asn Ile Pro Ile Leu Ser Ile Val Phe Thr Asn Asn
                  85                  90                  95

 cac agt gca atc aaa cta gaa ctc agg att aag aaa ctc act caa aac      336
 His Ser Ala Ile Lys Leu Glu Leu Arg Ile Lys Lys Leu Thr Gln Asn
             100                 105                 110

 tgc tca act aca tgg aaa ctg aac aac ctg ctc ctg aat gac tac tgg      384
 Cys Ser Thr Thr Trp Lys Leu Asn Asn Leu Leu Leu Asn Asp Tyr Trp
         115                 120                 125

 gta cat aac gaa atg aag gca gaa ata aag atg ttc ttt gaa acc aat      432
 Val His Asn Glu Met Lys Ala Glu Ile Lys Met Phe Phe Glu Thr Asn
     130                 135                 140

 gag aac aag gat aca aca tac cag aat ctc tgg gac aca ttc aaa gca      480
 Glu Asn Lys Asp Thr Thr Tyr Gln Asn Leu Trp Asp Thr Phe Lys Ala
 145                 150                 155                 160

 gtg agc agg ccg ttg gca caa gag caa cat gac cac act ctg att gag      528
 Val Ser Arg Pro Leu Ala Gln Glu Gln His Asp His Thr Leu Ile Glu
                 165                 170                 175

 tgg caa tgg gca gcc ata cgg act gtg tgg aat gac gct ggt gaa ata      576
 Trp Gln Trp Ala Ala Ile Arg Thr Val Trp Asn Asp Ala Gly Glu Ile
             180                 185                 190

 ccc aaa act gag agt aaa tgg cag tcg tat gcc aat ttg gtg gaa gtc      624
 Pro Lys Thr Glu Ser Lys Trp Gln Ser Tyr Ala Asn Leu Val Glu Val
         195                 200                 205

 atc cag gag atg gct ata cca tca atc atg gat ttg atg gac tgt ttg      672
 Ile Gln Glu Met Ala Ile Pro Ser Ile Met Asp Leu Met Asp Cys Leu
     210                 215                 220

 atg aca gaa ctg gga cag tac aac tat att tat aag tgg ctg gac ccc      720
 Met Thr Glu Leu Gly Gln Tyr Asn Tyr Ile Tyr Lys Trp Leu Asp Pro
 225                 230                 235                 240

 tct tgc acc aac gtt tgg cag cat gtg att ggg ctg tca atg aat cca      768
 Ser Cys Thr Asn Val Trp Gln His Val Ile Gly Leu Ser Met Asn Pro
                 245                 250                 255

 agg tcc aag gac ctg gat tat ctg cca aat tct tgg gag tta cct gat      816
 Arg Ser Lys Asp Leu Asp Tyr Leu Pro Asn Ser Trp Glu Leu Pro Asp
             260                 265                 270

 cag cct tgc agt atg gct gac caa cag aat acc atc tgg gcc ctg aaa      864
 Gln Pro Cys Ser Met Ala Asp Gln Gln Asn Thr Ile Trp Ala Leu Lys
         275                 280                 285

 tgt gta tgt gcc ctc tat ggt cgc cct ctg gct act gaa gtg ata gaa      912
 Cys Val Cys Ala Leu Tyr Gly Arg Pro Leu Ala Thr Glu Val Ile Glu
     290                 295                 300

 cac att tca ctg gat aac aga tac ata cca aag atg atc tcc tcc gac      960
 His Ile Ser Leu Asp Asn Arg Tyr Ile Pro Lys Met Ile Ser Ser Asp
 305                 310                 315                 320

 cag gtt aac atg ctc caa ctg cat tgt gga ctg ggc cca cac cta cac     1008
 Gln Val Asn Met Leu Gln Leu His Cys Gly Leu Gly Pro His Leu His
                 325                 330                 335

 tgc agt gac caa tgt ttc cga ctg ttg gat ctg cac cgc cct tcc agc     1056
 Cys Ser Asp Gln Cys Phe Arg Leu Leu Asp Leu His Arg Pro Ser Ser
             340                 345                 350

 agc agc agc gaa tgg ctt gtc ttg gca cat aca ttc agc atc tgc aga     1104
 Ser Ser Ser Glu Trp Leu Val Leu Ala His Thr Phe Ser Ile Cys Arg
         355                 360                 365

 gaa ctg gac ata acc aga tac ctg ttc ttt cag tgt ggc tgc aaa gcc     1152
 Glu Leu Asp Ile Thr Arg Tyr Leu Phe Phe Gln Cys Gly Cys Lys Ala
     370                 375                 380

 att tcc aac aac act gtg atc cca gta tgt gcc ttg ctg gcc ccc tta     1200
 Ile Ser Asn Asn Thr Val Ile Pro Val Cys Ala Leu Leu Ala Pro Leu
 385                 390                 395                 400

 ctt agg cag cct ctg gga gaa aga aag aaa gaa atg cat tta acc aag     1248
 Leu Arg Gln Pro Leu Gly Glu Arg Lys Lys Glu Met His Leu Thr Lys
                 405                 410                 415

 gag gtg aaa gat gtc tac aag gag gac tac gaa acg ctg ccg aaa gaa     1296
 Glu Val Lys Asp Val Tyr Lys Glu Asp Tyr Glu Thr Leu Pro Lys Glu
             420                 425                 430

 atc ata gac ggc aca aac aaa tgg gaa agc att cca cgc tgg tgt gtt     1344
 Ile Ile Asp Gly Thr Asn Lys Trp Glu Ser Ile Pro Arg Trp Cys Val
         435                 440                 445

 gaa aga atc aat atg att aaa atg tcc ata ctg ggt cag tct aga ggg     1392
 Glu Arg Ile Asn Met Ile Lys Met Ser Ile Leu Gly Gln Ser Arg Gly
     450                 455                 460

 aag cac aaa tat tca aac cat agc aac agc tat gtg aag acc aac act     1440
 Lys His Lys Tyr Ser Asn His Ser Asn Ser Tyr Val Lys Thr Asn Thr
 465                 470                 475                 480

 tcc ttc aaa gcg ttg ctc aag cat tgc ttg ctc cac tac aag aag acg     1488
 Ser Phe Lys Ala Leu Leu Lys His Cys Leu Leu His Tyr Lys Lys Thr
                 485                 490                 495

 gat gag aaa gta aca tgc ttc tgg cag cgt gtt atc aat tgg gag gca     1536
 Asp Glu Lys Val Thr Cys Phe Trp Gln Arg Val Ile Asn Trp Glu Ala
             500                 505                 510

 gca gtg cat tcc ctc tat gtg gaa cag tga                             1566
 Ala Val His Ser Leu Tyr Val Glu Gln 
         515                 520





      <210> 686
      <211> 948
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (1)..(948)

      <400> 686
  atg ccc aca gca tcc atc acc ttg ggt cct ggc gcc ctc ctg agc ccg      48
  Met Pro Thr Ala Ser Ile Thr Leu Gly Pro Gly Ala Leu Leu Ser Pro
    1               5                  10                  15

 tcg tcc ctt gct ggc tgc cca ctt gct cag ctg cgc cct gga ccg tgg       96
 Ser Ser Leu Ala Gly Cys Pro Leu Ala Gln Leu Arg Pro Gly Pro Trp
              20                  25                  30

 ccg ctg ggc tcc tgg gag gtg ggc cat gcc cac agc tcc acc tgg ctc      144
 Pro Leu Gly Ser Trp Glu Val Gly His Ala His Ser Ser Thr Trp Leu
          35                  40                  45

 aca gtc gtg cac aca cac aag ccg cac ttc atg gcc ttg cac tgt cag      192
 Thr Val Val His Thr His Lys Pro His Phe Met Ala Leu His Cys Gln
      50                  55                  60

 gag ttt gga ggg aag aac tac gag gcc tcc atg tcc cac gtg gac aag      240
 Glu Phe Gly Gly Lys Asn Tyr Glu Ala Ser Met Ser His Val Asp Lys
  65                  70                  75                  80

 ttc gtc aaa gaa cta ttg tcg agt gat gcg atg aaa gaa tat aac agg      288
 Phe Val Lys Glu Leu Leu Ser Ser Asp Ala Met Lys Glu Tyr Asn Arg
                  85                  90                  95

 gct cga gtc tac ctg gat gaa aac tac aaa tcc cag gag cac ttc acg      336
 Ala Arg Val Tyr Leu Asp Glu Asn Tyr Lys Ser Gln Glu His Phe Thr
             100                 105                 110

 gtg gga ctc tca ttg ctg ttt ggg ttc aag ggc cat ctc act tgt ttg      384
 Val Gly Leu Ser Leu Leu Phe Gly Phe Lys Gly His Leu Thr Cys Leu
         115                 120                 125

 ggc atc cag tgc cag ttg atc aat gtc ctt gtc cct gag atg gtc aca      432
 Gly Ile Gln Cys Gln Leu Ile Asn Val Leu Val Pro Glu Met Val Thr
     130                 135                 140

 cag ctg tca tgc gtg gtc ccc acc agt agt gga gtc tgt aca atc ccg      480
 Gln Leu Ser Cys Val Val Pro Thr Ser Ser Gly Val Cys Thr Ile Pro
 145                 150                 155                 160

 gga atc ccc cgt tcg gtc tcc gac cct cgc cct gtc aag cag ctg ccc      528
 Gly Ile Pro Arg Ser Val Ser Asp Pro Arg Pro Val Lys Gln Leu Pro
                 165                 170                 175

 aca cac aag cgg cct ctc ctc acg ctc tgc ccc cga ggg ctg cgg ctg      576
 Thr His Lys Arg Pro Leu Leu Thr Leu Cys Pro Arg Gly Leu Arg Leu
             180                 185                 190

 cct cca cac ctg gct ttc agg gtt ttc cag ctc agt ggg ctc cag ccc      624
 Pro Pro His Leu Ala Phe Arg Val Phe Gln Leu Ser Gly Leu Gln Pro
         195                 200                 205

 cgg ctt ccc tgc ctg ggc acg gac ctg atc tct ccc aca gcc acg gcc      672
 Arg Leu Pro Cys Leu Gly Thr Asp Leu Ile Ser Pro Thr Ala Thr Ala
     210                 215                 220

 ctg agt gag gct tta ggc cag gtg gat ggt gga ggg cag cct tgc ctg      720
 Leu Ser Glu Ala Leu Gly Gln Val Asp Gly Gly Gly Gln Pro Cys Leu
 225                 230                 235                 240

 gca gct cca aca gca cag aaa tcc cgt gtc ttg tct gcc ggg cac gca      768
 Ala Ala Pro Thr Ala Gln Lys Ser Arg Val Leu Ser Ala Gly His Ala
                 245                 250                 255

 ggg agc tcc gag aac aca tca gtc agc gcc cag aga gcc gac gtc ggc      816
 Gly Ser Ser Glu Asn Thr Ser Val Ser Ala Gln Arg Ala Asp Val Gly
             260                 265                 270

 cag agg acg cag ggt aac ggc ttt cct gaa ctc cgc ttc caa gag ggt      864
 Gln Arg Thr Gln Gly Asn Gly Phe Pro Glu Leu Arg Phe Gln Glu Gly
         275                 280                 285

 tct cgg gca ggt aat gac ctg ctc ccc ggc ccc agc acc tgc agt ccc      912
 Ser Arg Ala Gly Asn Asp Leu Leu Pro Gly Pro Ser Thr Cys Ser Pro
     290                 295                 300

 gtg gga cgc gat gat gtg cgg ctg ggg ctg cag tga                      948
 Val Gly Arg Asp Asp Val Arg Leu Gly Leu Gln 
 305                 310                 315





      <210> 687
      <211> 513
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (1)..(513)

      <400> 687
  atg cgg cca tgg act ggt tcc tgg cgt tgg att atg ctc att ctt ttt      48
  Met Arg Pro Trp Thr Gly Ser Trp Arg Trp Ile Met Leu Ile Leu Phe
    1               5                  10                  15

 gcc tgg ggg acc ttg ctg ttt tat ata ggt ggt cac ttg gta cga gat       96
 Ala Trp Gly Thr Leu Leu Phe Tyr Ile Gly Gly His Leu Val Arg Asp
              20                  25                  30

 aat gac cat cct gat cac tct agc cga gaa ctg tcc aag att ctg gca      144
 Asn Asp His Pro Asp His Ser Ser Arg Glu Leu Ser Lys Ile Leu Ala
          35                  40                  45

 aag ctt gaa cgc tta aaa caa cag aat gaa gac ttg agg cga atg gcc      192
 Lys Leu Glu Arg Leu Lys Gln Gln Asn Glu Asp Leu Arg Arg Met Ala
      50                  55                  60

 gaa tct ctc cgg gat gtc gtt tta gag ccc tct ggc atg aaa gga aga      240
 Glu Ser Leu Arg Asp Val Val Leu Glu Pro Ser Gly Met Lys Gly Arg
  65                  70                  75                  80

 gca atg gag ctt tgc ctg ctc ccc acc cac aac aaa gat ggt tca gat      288
 Ala Met Glu Leu Cys Leu Leu Pro Thr His Asn Lys Asp Gly Ser Asp
                  85                  90                  95

 ggt tca gta gaa act ggt tat gtg gaa tgt aag gag ata acg gtc atc      336
 Gly Ser Val Glu Thr Gly Tyr Val Glu Cys Lys Glu Ile Thr Val Ile
             100                 105                 110

 tta gac atg ctg atc tat gcc tgt tat atc ttt gat ccc act tat tac      384
 Leu Asp Met Leu Ile Tyr Ala Cys Tyr Ile Phe Asp Pro Thr Tyr Tyr
         115                 120                 125

 tta gtc cag tac ctc tgg cat aac atc agt gtg tta tca gct cag tgt      432
 Leu Val Gln Tyr Leu Trp His Asn Ile Ser Val Leu Ser Ala Gln Cys
     130                 135                 140

 gtc ctt tgc ctc att gca ttg ggt ggc tgc cct ctg cca gtt ttt gaa      480
 Val Leu Cys Leu Ile Ala Leu Gly Gly Cys Pro Leu Pro Val Phe Glu
 145                 150                 155                 160

 gga gat gat ggt atg gat ttg cag aat agt tag                          513
 Gly Asp Asp Gly Met Asp Leu Gln Asn Ser 
                 165                 170





      <210> 688
      <211> 1895
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (27)..(1895)

      <400> 688
 ggctgcagtg tcgcccactg ggcctg atg gca gcg act gtg ctc gcc acc tgg      53
                              Met Ala Ala Thr Val Leu Ala Thr Trp
                                1               5

 tgg tgg gaa aga ggt gct cat ggt gaa gca ttg cca ggc cta aag aga      101
 Trp Trp Glu Arg Gly Ala His Gly Glu Ala Leu Pro Gly Leu Lys Arg
  10                  15                  20                  25

 aat tgc tcg caa atg aaa aaa acc atg cag gga agg gca ctg agg gca      149
 Asn Cys Ser Gln Met Lys Lys Thr Met Gln Gly Arg Ala Leu Arg Ala
                  30                  35                  40

 gag tca ggc agg tgt gaa ggc cca cac ttc aca aag ggc agc ttg aaa      197
 Glu Ser Gly Arg Cys Glu Gly Pro His Phe Thr Lys Gly Ser Leu Lys
              45                  50                  55

 ggg gat gtg gag cag atg ggc cag ggg gag gaa tct ttt aag ggc caa      245
 Gly Asp Val Glu Gln Met Gly Gln Gly Glu Glu Ser Phe Lys Gly Gln
          60                  65                  70

 gta gag gaa acc ctt tct cat cca gca gac caa cag gca gga gtt gga      293
 Val Glu Glu Thr Leu Ser His Pro Ala Asp Gln Gln Ala Gly Val Gly
      75                  80                  85

 gaa gaa cct aga gag aca ggg aag gtt tca tct caa cac cag caa gaa      341
 Glu Glu Pro Arg Glu Thr Gly Lys Val Ser Ser Gln His Gln Gln Glu
  90                  95                 100                 105

 cgg agg gac tgg cca ggg cac cct gtg ctg cag gga gaa agg gct gat      389
 Arg Arg Asp Trp Pro Gly His Pro Val Leu Gln Gly Glu Arg Ala Asp
                 110                 115                 120

 gtc tgc att ctg gga tta ttg aga ttg gaa gag aga aga aaa gag ctg      437
 Val Cys Ile Leu Gly Leu Leu Arg Leu Glu Glu Arg Arg Lys Glu Leu
             125                 130                 135

 cta cag aaa ctt gaa gaa act act aaa tta act act tat ttg cat tca      485
 Leu Gln Lys Leu Glu Glu Thr Thr Lys Leu Thr Thr Tyr Leu His Ser
         140                 145                 150

 caa ctt aaa agc ctc tct gcc agc acc ctg tcc atg tca tct ggg agc      533
 Gln Leu Lys Ser Leu Ser Ala Ser Thr Leu Ser Met Ser Ser Gly Ser
     155                 160                 165

 agc ctg ggt tcc ctg gca tcg agt cgg ggc tct ctg aac acc tcc agc      581
 Ser Leu Gly Ser Leu Ala Ser Ser Arg Gly Ser Leu Asn Thr Ser Ser
 170                 175                 180                 185

 aga ggg tca ctc aac tcc ctc agt tcc acc gaa ctc tat tac agc agt      629
 Arg Gly Ser Leu Asn Ser Leu Ser Ser Thr Glu Leu Tyr Tyr Ser Ser
                 190                 195                 200

 caa agt gat cag ata gat gtg gat tat cag tat aaa ctg gac ttc ctt      677
 Gln Ser Asp Gln Ile Asp Val Asp Tyr Gln Tyr Lys Leu Asp Phe Leu
             205                 210                 215

 ctg caa gag aaa agc ggt tac att cct tct gga ccc atc acc acc atc      725
 Leu Gln Glu Lys Ser Gly Tyr Ile Pro Ser Gly Pro Ile Thr Thr Ile
         220                 225                 230

 cat gaa aac gag gtg gtc aag tcc cct agc cag cct ggc cag agt gga      773
 His Glu Asn Glu Val Val Lys Ser Pro Ser Gln Pro Gly Gln Ser Gly
     235                 240                 245

 ctc tgt gga gtg gca gct gca gca aca ggc cac act cct cca ctg gct      821
 Leu Cys Gly Val Ala Ala Ala Ala Thr Gly His Thr Pro Pro Leu Ala
 250                 255                 260                 265

 gag gcc ccg aag tct gtg gcc tcc ctg tcc tcg agg tcc tcc ctt tcc      869
 Glu Ala Pro Lys Ser Val Ala Ser Leu Ser Ser Arg Ser Ser Leu Ser
                 270                 275                 280

 tcc ttg tct cct cca ggc tct ccc ttg gtt ttg gaa ggc acg ttt ccc      917
 Ser Leu Ser Pro Pro Gly Ser Pro Leu Val Leu Glu Gly Thr Phe Pro
             285                 290                 295

 atg tct tct tct cat gat gcc tct ctc cat cag ttc act gct gac ttt      965
 Met Ser Ser Ser His Asp Ala Ser Leu His Gln Phe Thr Ala Asp Phe
         300                 305                 310

 gaa gac tgt gag ttg agt agc cat ttt gca gat atc agc ctc atc gaa     1013
 Glu Asp Cys Glu Leu Ser Ser His Phe Ala Asp Ile Ser Leu Ile Glu
     315                 320                 325

 aat cag att ttg ctg gat tct gat tca gga gga gcc tcc cag tct ctt     1061
 Asn Gln Ile Leu Leu Asp Ser Asp Ser Gly Gly Ala Ser Gln Ser Leu
 330                 335                 340                 345

 tca gag gat aaa gac ctt aat gaa tgt gct agg gag cca tta tat gaa     1109
 Ser Glu Asp Lys Asp Leu Asn Glu Cys Ala Arg Glu Pro Leu Tyr Glu
                 350                 355                 360

 gga act gca gat gtg gaa aaa tca tta cca aaa aga aga gtg atc cac     1157
 Gly Thr Ala Asp Val Glu Lys Ser Leu Pro Lys Arg Arg Val Ile His
             365                 370                 375

 ttg ctt ggg gag aaa acc act tgt gtg tcg gct gct gtg tct gat gag     1205
 Leu Leu Gly Glu Lys Thr Thr Cys Val Ser Ala Ala Val Ser Asp Glu
         380                 385                 390

 tct gtg gct gga gac agt ggg gtc tat gaa gct ttc gtg aaa caa cct     1253
 Ser Val Ala Gly Asp Ser Gly Val Tyr Glu Ala Phe Val Lys Gln Pro
     395                 400                 405

 agt gaa atg gaa gat gtc aca tac agt gaa gag gat gta gcc att gta     1301
 Ser Glu Met Glu Asp Val Thr Tyr Ser Glu Glu Asp Val Ala Ile Val
 410                 415                 420                 425

 gag acc gcc cag gtt cag ata gga ctc aga tac aat gca aaa agt tca     1349
 Glu Thr Ala Gln Val Gln Ile Gly Leu Arg Tyr Asn Ala Lys Ser Ser
                 430                 435                 440

 agt ttc atg gtg att ata gca cag ctc cga aac ctt cat gcc ttc ttg     1397
 Ser Phe Met Val Ile Ile Ala Gln Leu Arg Asn Leu His Ala Phe Leu
             445                 450                 455

 ata cct cat act tca aaa gta tat ttt agg gtt gcc gtt ctt cct tcc     1445
 Ile Pro His Thr Ser Lys Val Tyr Phe Arg Val Ala Val Leu Pro Ser
         460                 465                 470

 tca act gat gtc agc tgt ctg ttt cgc aca aaa gtt cat ccg ccc aca     1493
 Ser Thr Asp Val Ser Cys Leu Phe Arg Thr Lys Val His Pro Pro Thr
     475                 480                 485

 gaa tcc att tta ttc aat gat gtg ttc aga gtc gcc att tcc caa aca     1541
 Glu Ser Ile Leu Phe Asn Asp Val Phe Arg Val Ala Ile Ser Gln Thr
 490                 495                 500                 505

 gcc tta caa cag aag aca ctg agg gta gac ctt tgc tct gtc agt aaa     1589
 Ala Leu Gln Gln Lys Thr Leu Arg Val Asp Leu Cys Ser Val Ser Lys
                 510                 515                 520

 cac cga agg gaa gaa tgc ctg gct gga act cag atc agc ctg gca gat     1637
 His Arg Arg Glu Glu Cys Leu Ala Gly Thr Gln Ile Ser Leu Ala Asp
             525                 530                 535

 tta cca ttt tcc agt gag gtt ttc act cta tgg tat aac ttg ctt cct     1685
 Leu Pro Phe Ser Ser Glu Val Phe Thr Leu Trp Tyr Asn Leu Leu Pro
         540                 545                 550

 tcc aag caa atg cct tgc aaa aag aat gaa gaa aat gag gac tct gta     1733
 Ser Lys Gln Met Pro Cys Lys Lys Asn Glu Glu Asn Glu Asp Ser Val
     555                 560                 565

 ttt caa cca aac cag ccg tta gta gat tct ata gac ttg aac ttc cca     1781
 Phe Gln Pro Asn Gln Pro Leu Val Asp Ser Ile Asp Leu Asn Phe Pro
 570                 575                 580                 585

 gac aat att gaa aga aat tgt aag agc aga cat cct tgt ctt cgt cct     1829
 Asp Asn Ile Glu Arg Asn Cys Lys Ser Arg His Pro Cys Leu Arg Pro
                 590                 595                 600

 gat ctt agt gga aaa gct ttc agc ctt tca cca tta agt atg aat ttg     1877
 Asp Leu Ser Gly Lys Ala Phe Ser Leu Ser Pro Leu Ser Met Asn Leu
             605                 610                 615

 gct gtg gct ttt tca tag                                             1895
 Ala Val Ala Phe Ser 
         620





      <210> 689
      <211> 2469
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (1104)..(1688)

      <400> 689
 atggcacctg aaaacaacat gatggcagcc tcactgtacg tgacagatgc ggatacctgg     60

 tggggaaggg gcaccgtgca cagcacacgc agttcaaaga acggaaaaga tttgcaagga    120

 gactacaatt atgagagtaa gttaagtaag tgtgcatacg ggtggatgct gaggacttgc    180

 actcagtccc cacagatcaa ccacaacagc aaccccacac agacccaacg cgatgctgcc    240

 tgcagctgcg gctggaatga ctataccagt cttgagtact catcagacaa tgctgacttc    300

 agaaagctga atgaggattt acacgggaat gttctcagcg ccgctctcag ccttaacaac    360

 gtgttaccag aacagcccag tggagggaac ggtgttatgc tgatggaggc agtggtttgc    420

 ataagctcct tccagacgcc cttcccagga tcccgtgttg agatggtcat ggatggctgc    480

 cctgtgggcc tgtgttcctc tggagtgagg cccctcacct caacccaggg cttggagtgt    540

 ggggccagcc acgagcacca gcgctgcctg gaaactcggc agaaagcaaa ctttggccac    600

 acgacagacc tgccaggcca gaaactccag gagccggcac agcctgggcc catcaggccc    660

 tccgataaac ccagggaaga tgatgagaag aaacggcaaa ccaattccct tcaagccttc    720

 cacttggaaa ggcacgtcag acctacccgg gcaccggggc gtcttgtggg ccacggcagt    780

 gccgctgatg ggcctcccgt tgggcgtgac gcaccagcag tatcccgtgt agctgtgaca    840

 ctggacctgc gagagagcac aggacgggtg cagaacctcc caagcaaggc cggtaacctg    900

 actgtaggtg ccgtcgtcat tgcactcagg aatgaacact tgctgaaact ccttccgggc    960

 ttgctcctgg gtatacttcc tttcggccac acacctggac acgtctgtag ggaagaacag   1020

 ggcagagccc ttggccagca aaagcagcat gatgcatccc cacagcagca gactagcgca   1080

 tccgtccaac cttccctcaa cca    tga cca gaa cga cac cat ttc aga gct    1130
                              Met Val Glu Gly Arg Leu Asp Gly Cys
                                1               5

 aag gga gac agg aac gac att ttc gtt tta cga acg tcc ggc tgt gtt     1178
 Ala Ser Leu Leu Leu Trp Gly Cys Ile Met Leu Leu Leu Leu Ala Lys
  10                  15                  20                  25

 tct gat cac ggc tgc aca cga gac cga agg ccc tga atc tcc tgt tat     1226
 Gly Ser Ala Leu Phe Phe Pro Thr Asp Val Ser Arg Cys Val Ala Glu
                  30                  35                  40

 gtc tac ccc agc ctg tga gga agg gcg ctc cca aac atc aga cgt gtt     1274
 Arg Lys Tyr Thr Gln Glu Gln Ala Arg Lys Glu Phe Gln Gln Val Phe
              45                  50                  55

 aaa ata cca taa gcg agt taa ggt aaa cat act ctg ggt aga gtt tct     1322
 Ile Pro Glu Cys Asn Asp Asp Gly Thr Tyr Ser Gln Val Thr Gly Leu
          60                  65                  70

 gca aga cac aag cac aaa tcc gat tga agt tgc ttc tga taa ctg tgt     1370
 Ala Trp Glu Val Leu His Pro Ser Cys Ala Leu Ser Gln Val Gln Cys
      75                  80                  85

 ctg ctg gaa gaa gaa aat cca acc tgg aaa ggg tgc tga gaa gaa gct     1418
 His Ser Tyr Thr Gly Tyr Cys Trp Cys Val Thr Pro Asn Gly Arg Pro
  90                  95                 100                 105

 gcg agc cgc agg ggc cat tgc cgt gct ctc agg aaa act gca aca gaa     1466
 Ile Ser Gly Thr Ala Val Ala His Lys Thr Pro Arg Cys Pro Gly Arg
                 110                 115                 120

 gga gca gag cgc gtg gac gga gcc cca cgg gga ggc ctg gtt cct ctg     1514
 Ser Asp Val Pro Phe Gln Val Glu Gly Leu Lys Gly Ile Gly Leu Pro
             125                 130                 135

 gac cat gta cct ggc tcc acg cca act ttc cat aac cca tgg ccc tgc     1562
 Phe Leu Leu Ile Ile Phe Pro Gly Phe Ile Gly Gly Pro Asp Gly Pro
         140                 145                 150

 ggt ttc ctg ggt gaa gca tgc tgg aaa tca cgt tat ccc cgg aca gtt     1610
 Arg Leu Cys Arg Leu Leu Glu Phe Leu Ala Trp Gln Val Cys Arg Val
     155                 160                 165

 gtc caa cgc acc act gtc ctt cct agc caa tga agc aag act tct agc     1658
 Ala Lys Val Cys Phe Leu Pro Ser Phe Gln Ala Ala Leu Val Leu Val
 170                 175                 180                 185

 agt aga gta tcg gca gtg gaa gga gac act c attcagtgtg tggaacgaga     1709
 Ala Gly Pro Thr Leu Gln Ala Leu Gly 
                 190

 cacactgttc ttgaggattg ctgaagctaa ctgccagatg atgcagaact tcatctcaaa   1769

 ggcatcttta gtctttgtgg tcttttttcc tagatactat gacaaacaag aagcgccacg   1829

 tgcacctctg aacattttag ccatcatctg tttcaaaagc ctagataatt tggaagttct   1889

 ctacatcaat atcggccgtc tgacacagaa caacatgaca ttttctccca gagacggaca   1949

 tttcattcag tcattcatcc ggcatctgag agacggacat tccattcact cattcatcca   2009

 gcatctgaga gacggacatt tcattcagtc attcatccgg catctgagag acggacattc   2069

 cattcactca ttcatccggc atctgagaga tggacatttc attcagtcat tcatccagca   2129

 tctgagagat ggacatttca ttcagtcatt catccggcat ctgagataca gacatttcat   2189

 tcagtcattc atctggcatc tgagagatgg acatttcatt cagtcattca tccagcatct   2249

 gagagacgga catttcattc agtcattcat ccagcatctg agagacggac atttcattca   2309

 ctcattcatc tggcatctga gagatggaca tttcattcag tcattcatcc agcatctgag   2369

 agacagacat ttcattcact cattcatctg gcatctgaga gatggacatt tcattcagtc   2429

 attcatctgg catctgagag gcagacattt cattcactga                         2469




      <210> 690
      <211> 399
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (1)..(399)

      <400> 690
  atg agc tct aag tac ccg cgg tct gtc cgg cgc tgc ctg ccc ctc tgc      48
  Met Ser Ser Lys Tyr Pro Arg Ser Val Arg Arg Cys Leu Pro Leu Cys
    1               5                  10                  15

 gcc cta aca ctg gaa gca gct ctc att ctc ctc ttc tat ttt ttt acc       96
 Ala Leu Thr Leu Glu Ala Ala Leu Ile Leu Leu Phe Tyr Phe Phe Thr
              20                  25                  30

 cac tat gac gct tcc tta gag gat caa aag ggg ctc gtg gca tcc tat      144
 His Tyr Asp Ala Ser Leu Glu Asp Gln Lys Gly Leu Val Ala Ser Tyr
          35                  40                  45

 caa ggt gag agt tca ttg gaa cag tgg tca cag gag caa ata gca ggg      192
 Gln Gly Glu Ser Ser Leu Glu Gln Trp Ser Gln Glu Gln Ile Ala Gly
      50                  55                  60

 gca ggg gcg ggg gag gcc tat ggt tct cca ggg gca cag atg ttc ctt      240
 Ala Gly Ala Gly Glu Ala Tyr Gly Ser Pro Gly Ala Gln Met Phe Leu
  65                  70                  75                  80

 tct aca aaa tcc cga gga aaa gat tcc ccc atc ttc ttc cgt aga ttg      288
 Ser Thr Lys Ser Arg Gly Lys Asp Ser Pro Ile Phe Phe Arg Arg Leu
                  85                  90                  95

 cac cga aat tca gtc aac aat gga cag tgt aga gcc ttg ggg agg aag      336
 His Arg Asn Ser Val Asn Asn Gly Gln Cys Arg Ala Leu Gly Arg Lys
             100                 105                 110

 gcc ctg agc gca tat acc tgg aat cag gga atc ggg atc agg ggc agc      384
 Ala Leu Ser Ala Tyr Thr Trp Asn Gln Gly Ile Gly Ile Arg Gly Ser
         115                 120                 125

 agc tgt gcc cga taa                                                  399
 Ser Cys Ala Arg 
     130





      <210> 691
      <211> 609
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (1)..(609)

      <400> 691
  atg ggc ctg cta cag tgg ctt atg cct ata atc cca aca ctt act ggg      48
  Met Gly Leu Leu Gln Trp Leu Met Pro Ile Ile Pro Thr Leu Thr Gly
    1               5                  10                  15

 aag cca agg ctc acg act tat tta gat gta cag cgg tgc ctg gaa tat       96
 Lys Pro Arg Leu Thr Thr Tyr Leu Asp Val Gln Arg Cys Leu Glu Tyr
              20                  25                  30

 ttg ggc tat cta ggc tat tca ata ttg act gag caa gag tct caa gct      144
 Leu Gly Tyr Leu Gly Tyr Ser Ile Leu Thr Glu Gln Glu Ser Gln Ala
          35                  40                  45

 tca gct gtt aca gtg aca aga gat aaa aag ata gac ctg cag aaa aaa      192
 Ser Ala Val Thr Val Thr Arg Asp Lys Lys Ile Asp Leu Gln Lys Lys
      50                  55                  60

 caa act caa aga aat gtg ttc aga tgt aat gta att gga gtg aaa aac      240
 Gln Thr Gln Arg Asn Val Phe Arg Cys Asn Val Ile Gly Val Lys Asn
  65                  70                  75                  80

 tgt ggg aaa agt gga gtt ctt cag gct ctt ctt gga aga aac tta atg      288
 Cys Gly Lys Ser Gly Val Leu Gln Ala Leu Leu Gly Arg Asn Leu Met
                  85                  90                  95

 agg cag aag aaa att cgt gaa gat cat aaa tcc tac tat gcg att aac      336
 Arg Gln Lys Lys Ile Arg Glu Asp His Lys Ser Tyr Tyr Ala Ile Asn
             100                 105                 110

 act gtt tat gta tat gga caa gag aaa tac ttg ttg caa cac ttt atg      384
 Thr Val Tyr Val Tyr Gly Gln Glu Lys Tyr Leu Leu Gln His Phe Met
         115                 120                 125

 gac agc aga ata cct tgc tta atc gta gct gca aag tca gac ctg cat      432
 Asp Ser Arg Ile Pro Cys Leu Ile Val Ala Ala Lys Ser Asp Leu His
     130                 135                 140

 gaa gtt aaa caa gaa tac agt att tca cct act gat ttc tgc agg aaa      480
 Glu Val Lys Gln Glu Tyr Ser Ile Ser Pro Thr Asp Phe Cys Arg Lys
 145                 150                 155                 160

 cac aaa atg cct cca cca caa gcc ttc act tgc aat act gct gat gcc      528
 His Lys Met Pro Pro Pro Gln Ala Phe Thr Cys Asn Thr Ala Asp Ala
                 165                 170                 175

 ccc agt ctg gtg ttg cca ggt ttt ctg gtt tta caa gag act gga aat      576
 Pro Ser Leu Val Leu Pro Gly Phe Leu Val Leu Gln Glu Thr Gly Asn
             180                 185                 190

 caa ggc ttt ggt gtg aaa ttt cca gat tgt tag                          609
 Gln Gly Phe Gly Val Lys Phe Pro Asp Cys 
         195                 200





      <210> 692
      <211> 954
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (1)..(954)

      <400> 692
  atg aac tct ggc acc ctc agt acc ctg ctt att gat gtg aca gga gga      48
  Met Asn Ser Gly Thr Leu Ser Thr Leu Leu Ile Asp Val Thr Gly Gly
    1               5                  10                  15

 atg ttt ctg tgg aca ttc aag gtt atg gat cac tct cct gtt gcc atc       96
 Met Phe Leu Trp Thr Phe Lys Val Met Asp His Ser Pro Val Ala Ile
              20                  25                  30

 cag ctc tcc aca gct ggt gcc ctt gtg ggc ctg gag tcc agc atc ctg      144
 Gln Leu Ser Thr Ala Gly Ala Leu Val Gly Leu Glu Ser Ser Ile Leu
          35                  40                  45

 gtt cag gct tct gtc tgc agt cag tgg gca tac cat gta ctg tct agg      192
 Val Gln Ala Ser Val Cys Ser Gln Trp Ala Tyr His Val Leu Ser Arg
      50                  55                  60

 aat gtg gaa aga ggc tgc ctg gag cag ggc tct gct gga atc acg gaa      240
 Asn Val Glu Arg Gly Cys Leu Glu Gln Gly Ser Ala Gly Ile Thr Glu
  65                  70                  75                  80

 gga aca cac acc ctt ttt gag act atc aga att gca aag cct ggc cag      288
 Gly Thr His Thr Leu Phe Glu Thr Ile Arg Ile Ala Lys Pro Gly Gln
                  85                  90                  95

 ttg gtg caa gtg ttt atc cgc ctg cca tca cca tcg gca gag ttg aac      336
 Leu Val Gln Val Phe Ile Arg Leu Pro Ser Pro Ser Ala Glu Leu Asn
             100                 105                 110

 ggc tgc gag aga cat cat atg gcc cac aaa gcc aaa agt gtt tcc atc      384
 Gly Cys Glu Arg His His Met Ala His Lys Ala Lys Ser Val Ser Ile
         115                 120                 125

 tgg ctc ttt cca gaa gag cgt gct gac cct tgg ctg gag cca gca gag      432
 Trp Leu Phe Pro Glu Glu Arg Ala Asp Pro Trp Leu Glu Pro Ala Glu
     130                 135                 140

 cac ctt aaa ccc tat ttc caa aat aca ggc tac ttt tat tta cga att      480
 His Leu Lys Pro Tyr Phe Gln Asn Thr Gly Tyr Phe Tyr Leu Arg Ile
 145                 150                 155                 160

 tta ttc att ggg ttg gac aag cca aag gcc ata cct ttc aat cat att      528
 Leu Phe Ile Gly Leu Asp Lys Pro Lys Ala Ile Pro Phe Asn His Ile
                 165                 170                 175

 gaa gtg gtg ata cct cca gaa gca cag gaa aag agc ata ggt gtt ctt      576
 Glu Val Val Ile Pro Pro Glu Ala Gln Glu Lys Ser Ile Gly Val Leu
             180                 185                 190

 gtt gat gcc gga tat aaa tgc cca ggt acc aaa tca cag aat atg caa      624
 Val Asp Ala Gly Tyr Lys Cys Pro Gly Thr Lys Ser Gln Asn Met Gln
         195                 200                 205

 acc cag cat ccc aga gcc ccc agc acc aac atg gtg ctg ctg gca tgc      672
 Thr Gln His Pro Arg Ala Pro Ser Thr Asn Met Val Leu Leu Ala Cys
     210                 215                 220

 cag atc att cct cag ttc tac ctg gat tgt tta cac gat gag atc acc      720
 Gln Ile Ile Pro Gln Phe Tyr Leu Asp Cys Leu His Asp Glu Ile Thr
 225                 230                 235                 240

 aca acc cac aga agt ggc atc acc tgc ttt cag ccc ctt ggc cag gtg      768
 Thr Thr His Arg Ser Gly Ile Thr Cys Phe Gln Pro Leu Gly Gln Val
                 245                 250                 255

 aga tct cgg ctc acc aaa ttc cac aac ctg aag gca gtc gtc tgc aag      816
 Arg Ser Arg Leu Thr Lys Phe His Asn Leu Lys Ala Val Val Cys Lys
             260                 265                 270

 gcc tgc atg aag gag aac aga cgc atc act ggc cga gcc cac tgg ggc      864
 Ala Cys Met Lys Glu Asn Arg Arg Ile Thr Gly Arg Ala His Trp Gly
         275                 280                 285

 tca cac cac gca ggt ggg aaa ggg cca ggt gcc tct aga agc ccc aca      912
 Ser His His Ala Gly Gly Lys Gly Pro Gly Ala Ser Arg Ser Pro Thr
     290                 295                 300

 agc gta gac cct aac tgc ttc ctg agt ttt gtt gat aaa tga              954
 Ser Val Asp Pro Asn Cys Phe Leu Ser Phe Val Asp Lys 
 305                 310                 315





      <210> 693
      <211> 513
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (1)..(513)

      <400> 693
  atg gcc tgg gct ctg ctc ctc ctc acc ctc ctc act cag ggc aca gga      48
  Met Ala Trp Ala Leu Leu Leu Leu Thr Leu Leu Thr Gln Gly Thr Gly
    1               5                  10                  15

 tcc tgg gct cag tct gcc ctg act cag cct ccc tcc gtg tcc ggg tct       96
 Ser Trp Ala Gln Ser Ala Leu Thr Gln Pro Pro Ser Val Ser Gly Ser
              20                  25                  30

 cct gga cag tca gtc acc atc tcc tgc act gga acc agc agt gac gtt      144
 Pro Gly Gln Ser Val Thr Ile Ser Cys Thr Gly Thr Ser Ser Asp Val
          35                  40                  45

 ggt agt tat aac cgt gtc tcc tgg tac cag cag ccc cca ggc aca gcc      192
 Gly Ser Tyr Asn Arg Val Ser Trp Tyr Gln Gln Pro Pro Gly Thr Ala
      50                  55                  60

 ccc aaa ctc atg att tat gag aat ttt agc aac tac att cta atg gtt      240
 Pro Lys Leu Met Ile Tyr Glu Asn Phe Ser Asn Tyr Ile Leu Met Val
  65                  70                  75                  80

 atc gcc aca act ttg atc tta aat aac agt gca gcg aac atc cct acg      288
 Ile Ala Thr Thr Leu Ile Leu Asn Asn Ser Ala Ala Asn Ile Pro Thr
                  85                  90                  95

 cag act cct ttg agt tcc tgt gtg aat atg acc aca gga ttc att tct      336
 Gln Thr Pro Leu Ser Ser Cys Val Asn Met Thr Thr Gly Phe Ile Ser
             100                 105                 110

 aaa agt gaa att gca gat gtt gct gat gct gac ttg ttc atc tct tcc      384
 Lys Ser Glu Ile Ala Asp Val Ala Asp Ala Asp Leu Phe Ile Ser Ser
         115                 120                 125

 aac ctc tgc aaa caa agt ggg aaa ttg gat ttt tct gaa cac cca gat      432
 Asn Leu Cys Lys Gln Ser Gly Lys Leu Asp Phe Ser Glu His Pro Asp
     130                 135                 140

 gac aac ggg aga gga ggc ttt gtg gct tcc cgt aag ctg act cca gag      480
 Asp Asn Gly Arg Gly Gly Phe Val Ala Ser Arg Lys Leu Thr Pro Glu
 145                 150                 155                 160

 cca gca gtg tct gtg gac agt cag caa ggg taa                          513
 Pro Ala Val Ser Val Asp Ser Gln Gln Gly 
                 165                 170





      <210> 694
      <211> 2082
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (1)..(2082)

      <400> 694
  atg ggg ttt cgc tat gtt gcc cag gca ggt ctc aca ctc ctg ggc tca      48
  Met Gly Phe Arg Tyr Val Ala Gln Ala Gly Leu Thr Leu Leu Gly Ser
    1               5                  10                  15

 acc att ctg ccc acc ttc cct ccc aga gtg ctg gga tta cag cta gaa       96
 Thr Ile Leu Pro Thr Phe Pro Pro Arg Val Leu Gly Leu Gln Leu Glu
              20                  25                  30

 gcc tct gtg gct ggt ggt gcc ttt gcc cag gtt ttg ctc ggg cct gct      144
 Ala Ser Val Ala Gly Gly Ala Phe Ala Gln Val Leu Leu Gly Pro Ala
          35                  40                  45

 ggg tgt gtt ctg cct act cgg act ggc agg ctt tgt tcg act cgt gct      192
 Gly Cys Val Leu Pro Thr Arg Thr Gly Arg Leu Cys Ser Thr Arg Ala
      50                  55                  60

 atc agc tcg gat ccc acg cct gcc aag ggt gag cca gac atg gat cgg      240
 Ile Ser Ser Asp Pro Thr Pro Ala Lys Gly Glu Pro Asp Met Asp Arg
  65                  70                  75                  80

 cag ggg gtg cat ggg caa gca gca gct tct gtg ggc act gag gaa cgc      288
 Gln Gly Val His Gly Gln Ala Ala Ala Ser Val Gly Thr Glu Glu Arg
                  85                  90                  95

 agt ggc acc caa aag ctt gga gac aca agg aac tac aga gcc cca aag      336
 Ser Gly Thr Gln Lys Leu Gly Asp Thr Arg Asn Tyr Arg Ala Pro Lys
             100                 105                 110

 agg ttg tca cag ccc tgg ttc agg gag ctc cta ggt ctg gac tcc cca      384
 Arg Leu Ser Gln Pro Trp Phe Arg Glu Leu Leu Gly Leu Asp Ser Pro
         115                 120                 125

 aag ggt cag agc tct tcc gtc ctt gtc gcc ggc agc atg tct aca tca      432
 Lys Gly Gln Ser Ser Ser Val Leu Val Ala Gly Ser Met Ser Thr Ser
     130                 135                 140

 gca tca gca tct gcg tca cca ttt caa tct gca tgg tat agt gaa tct      480
 Ala Ser Ala Ser Ala Ser Pro Phe Gln Ser Ala Trp Tyr Ser Glu Ser
 145                 150                 155                 160

 gag ata act cag gga gca cgc tca aga tcg cag aac cag caa cgg gat      528
 Glu Ile Thr Gln Gly Ala Arg Ser Arg Ser Gln Asn Gln Gln Arg Asp
                 165                 170                 175

 cat gat tca aaa aga cct aaa ctt tcc tgt aca aac tgt act acc tca      576
 His Asp Ser Lys Arg Pro Lys Leu Ser Cys Thr Asn Cys Thr Thr Ser
             180                 185                 190

 gct ggg aga aat gtt gga aat ggt tta aac aca tta tca gat gtt caa      624
 Ala Gly Arg Asn Val Gly Asn Gly Leu Asn Thr Leu Ser Asp Val Gln
         195                 200                 205

 gac aga gtt cct tca tat tca caa gga gca aga cca aaa gaa aac tca      672
 Asp Arg Val Pro Ser Tyr Ser Gln Gly Ala Arg Pro Lys Glu Asn Ser
     210                 215                 220

 atg agc act tta cag ttg aat aca tca tcc aca aac cac caa ttg cct      720
 Met Ser Thr Leu Gln Leu Asn Thr Ser Ser Thr Asn His Gln Leu Pro
 225                 230                 235                 240

 tct gaa cat cag acc ata cta agt tct agg gac tcc aga aat tct tta      768
 Ser Glu His Gln Thr Ile Leu Ser Ser Arg Asp Ser Arg Asn Ser Leu
                 245                 250                 255

 aga tca aat ttt tct tca aga gaa tca gaa tct tcc cga agc aat acg      816
 Arg Ser Asn Phe Ser Ser Arg Glu Ser Glu Ser Ser Arg Ser Asn Thr
             260                 265                 270

 cag cct gga ttt tct tac agt tca agt aga gat gaa gcc cca atc ata      864
 Gln Pro Gly Phe Ser Tyr Ser Ser Ser Arg Asp Glu Ala Pro Ile Ile
         275                 280                 285

 agc aat tca gaa agg gtt gtt tca tct caa aga cca ttt caa gaa tct      912
 Ser Asn Ser Glu Arg Val Val Ser Ser Gln Arg Pro Phe Gln Glu Ser
     290                 295                 300

 tct gac aat gaa ggt agg cgg aca acg agg aga ttg ctg tca cgc ata      960
 Ser Asp Asn Glu Gly Arg Arg Thr Thr Arg Arg Leu Leu Ser Arg Ile
 305                 310                 315                 320

 gct tct agc atg tca tct act ttt ttt tca cga aga tct agt cag gat     1008
 Ala Ser Ser Met Ser Ser Thr Phe Phe Ser Arg Arg Ser Ser Gln Asp
                 325                 330                 335

 tcc ttg aat aca aga tca ttg aat tct gaa aat tct tac gtt tct cca     1056
 Ser Leu Asn Thr Arg Ser Leu Asn Ser Glu Asn Ser Tyr Val Ser Pro
             340                 345                 350

 aga atc ttg aca gct tca cag tcc cgt agt aat gta cca tca gct tct     1104
 Arg Ile Leu Thr Ala Ser Gln Ser Arg Ser Asn Val Pro Ser Ala Ser
         355                 360                 365

 gaa gtt ccc gat aat agg gca tct gaa gct tct cag gga ttt cga ttt     1152
 Glu Val Pro Asp Asn Arg Ala Ser Glu Ala Ser Gln Gly Phe Arg Phe
     370                 375                 380

 ctt agg cga aga tgg ggt ttg tca tct ctt agc cac aat cat agc tct     1200
 Leu Arg Arg Arg Trp Gly Leu Ser Ser Leu Ser His Asn His Ser Ser
 385                 390                 395                 400

 gag tca gat tca gaa aat ttt aac caa gaa tct gaa ggt aga aat aca     1248
 Glu Ser Asp Ser Glu Asn Phe Asn Gln Glu Ser Glu Gly Arg Asn Thr
                 405                 410                 415

 gga cca tgg tta tct tcc tca ctt aga aat aga tgc aca cct ttg ttc     1296
 Gly Pro Trp Leu Ser Ser Ser Leu Arg Asn Arg Cys Thr Pro Leu Phe
             420                 425                 430

 tct aga agg agg cga gag gga aga gat gaa tct tca agg ata cct acc     1344
 Ser Arg Arg Arg Arg Glu Gly Arg Asp Glu Ser Ser Arg Ile Pro Thr
         435                 440                 445

 tct gat aca tca tct aga tct cat att ttt aga aga gaa tca aat gaa     1392
 Ser Asp Thr Ser Ser Arg Ser His Ile Phe Arg Arg Glu Ser Asn Glu
     450                 455                 460

 gtg gtt cac ctt gaa gca cag aat gat cct ctt gga gct gct gcc aac     1440
 Val Val His Leu Glu Ala Gln Asn Asp Pro Leu Gly Ala Ala Ala Asn
 465                 470                 475                 480

 aga cca caa gca tct gca gca tca agc agt gcc aca aca ggt ggc tct     1488
 Arg Pro Gln Ala Ser Ala Ala Ser Ser Ser Ala Thr Thr Gly Gly Ser
                 485                 490                 495

 aca tca gat tcg gct caa ggt gga aga aat aca gga ata tca ggg att     1536
 Thr Ser Asp Ser Ala Gln Gly Gly Arg Asn Thr Gly Ile Ser Gly Ile
             500                 505                 510

 ctt cct ggt tcc tta ttc cgg ttt gca gtc cct cca gca ctt ggg agt     1584
 Leu Pro Gly Ser Leu Phe Arg Phe Ala Val Pro Pro Ala Leu Gly Ser
         515                 520                 525

 aat ttg acc gac aat gtc atg atc aca gta gat att att cct tca ggt     1632
 Asn Leu Thr Asp Asn Val Met Ile Thr Val Asp Ile Ile Pro Ser Gly
     530                 535                 540

 tgg aat tca gct gat ggt aaa agt gat aaa act aaa agt gcg cct tca     1680
 Trp Asn Ser Ala Asp Gly Lys Ser Asp Lys Thr Lys Ser Ala Pro Ser
 545                 550                 555                 560

 aga gat cca gaa aga ttg cag aaa ata aaa gag agc ctc ctt tta gag     1728
 Arg Asp Pro Glu Arg Leu Gln Lys Ile Lys Glu Ser Leu Leu Leu Glu
                 565                 570                 575

 gac tca gaa gaa gaa gaa ggt gac tta tgt aga att tgt caa atg gca     1776
 Asp Ser Glu Glu Glu Glu Gly Asp Leu Cys Arg Ile Cys Gln Met Ala
             580                 585                 590

 gct gca tca tca tct aat ttg ctg ata gag cca tgc aag tgc aca gga     1824
 Ala Ala Ser Ser Ser Asn Leu Leu Ile Glu Pro Cys Lys Cys Thr Gly
         595                 600                 605

 agt ttg cag tat gtc cac caa gac tgt atg aaa aag tgg tta cag gcc     1872
 Ser Leu Gln Tyr Val His Gln Asp Cys Met Lys Lys Trp Leu Gln Ala
     610                 615                 620

 aaa att aac tct ggt tct tca tta gaa gct gta acc acc tgt gaa cta     1920
 Lys Ile Asn Ser Gly Ser Ser Leu Glu Ala Val Thr Thr Cys Glu Leu
 625                 630                 635                 640

 tgt aaa gag aag ttg gag ctt aac ctg gag gat ttt gat att cat gaa     1968
 Cys Lys Glu Lys Leu Glu Leu Asn Leu Glu Asp Phe Asp Ile His Glu
                 645                 650                 655

 cta cat aga gct cat gca aat gaa caa gtt agt ata ttt tgc cta att     2016
 Leu His Arg Ala His Ala Asn Glu Gln Val Ser Ile Phe Cys Leu Ile
             660                 665                 670

 tgg tta aca caa cag aac agt ttt gaa ttg aag aac tgt ttt tac caa     2064
 Trp Leu Thr Gln Gln Asn Ser Phe Glu Leu Lys Asn Cys Phe Tyr Gln
         675                 680                 685

 cta caa att tct gtg tga                                             2082
 Leu Gln Ile Ser Val 
     690





      <210> 695
      <211> 2514
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (1)..(2514)

      <400> 695
  atg gcc gtc atc tcg gtc ctt agc gct gcc tgc ctg gcc ttg gct gct      48
  Met Ala Val Ile Ser Val Leu Ser Ala Ala Cys Leu Ala Leu Ala Ala
    1               5                  10                  15

 ctg ttg gct gct cag ctt cag aac cgg gct gtg ggt cgg ccc aag ggg       96
 Leu Leu Ala Ala Gln Leu Gln Asn Arg Ala Val Gly Arg Pro Lys Gly
              20                  25                  30

 aag ctg ggc ccg gcc tcc gcg gtg aag ttg gcc gcc aac cgg aca acg      144
 Lys Leu Gly Pro Ala Ser Ala Val Lys Leu Ala Ala Asn Arg Thr Thr
          35                  40                  45

 gca gga gct cgg cgg cgc cgg acg cga tgc cgc aag tgc gag gcc tgc      192
 Ala Gly Ala Arg Arg Arg Arg Thr Arg Cys Arg Lys Cys Glu Ala Cys
      50                  55                  60

 ctg cgg acc gag tgc gga gag tgc cac ttc tgc aag gac atg aag aag      240
 Leu Arg Thr Glu Cys Gly Glu Cys His Phe Cys Lys Asp Met Lys Lys
  65                  70                  75                  80

 ttc ggg ggc ccc ggg cgc atg aag cag agc tgc atc atg cgg cag tgc      288
 Phe Gly Gly Pro Gly Arg Met Lys Gln Ser Cys Ile Met Arg Gln Cys
                  85                  90                  95

 atc gcg gcc cct gcg tgc cgg ccc gcg tgt ctg acc gct gct cgc tct      336
 Ile Ala Ala Pro Ala Cys Arg Pro Ala Cys Leu Thr Ala Ala Arg Ser
             100                 105                 110

 ggc cgc ccc tcc gca cac aga gaa gcc ggg gct gtg gac tcc ccg aga      384
 Gly Arg Pro Ser Ala His Arg Glu Ala Gly Ala Val Asp Ser Pro Arg
         115                 120                 125

 gct ctt cct gtg gac ggg aag gcg ctg gcc gct tcg cag gct cag gcc      432
 Ala Leu Pro Val Asp Gly Lys Ala Leu Ala Ala Ser Gln Ala Gln Ala
     130                 135                 140

 tcc tgc tcc ttc cct ccc agg gtg ctc agg gcg ctg ctc ccc ggg ggc      480
 Ser Cys Ser Phe Pro Pro Arg Val Leu Arg Ala Leu Leu Pro Gly Gly
 145                 150                 155                 160

 cgg cgg tcc tcc ctg tgg agg agt cat ctc cca gtc ccc gtg gaa aag      528
 Arg Arg Ser Ser Leu Trp Arg Ser His Leu Pro Val Pro Val Glu Lys
                 165                 170                 175

 cag gct cgg ctg gag gga cgg gat tcc tcg gcc ctg gtg cgc tca tct      576
 Gln Ala Arg Leu Glu Gly Arg Asp Ser Ser Ala Leu Val Arg Ser Ser
             180                 185                 190

 gca ggc cca gcc tgg cat agg cca gtg ctg ccc cac acc gcc gtg tgc      624
 Ala Gly Pro Ala Trp His Arg Pro Val Leu Pro His Thr Ala Val Cys
         195                 200                 205

 ctt gtg tgt ggc gag gcg ggg aag gaa gac acg gtg gaa gag gag gaa      672
 Leu Val Cys Gly Glu Ala Gly Lys Glu Asp Thr Val Glu Glu Glu Glu
     210                 215                 220

 ggc aag ttt aac ctc atg ctc atg gag tgc tcc atc tgc aat gaa atc      720
 Gly Lys Phe Asn Leu Met Leu Met Glu Cys Ser Ile Cys Asn Glu Ile
 225                 230                 235                 240

 atc cac cct gga tgc ctt aag att aag gag tca gag ggt gtg gtc aac      768
 Ile His Pro Gly Cys Leu Lys Ile Lys Glu Ser Glu Gly Val Val Asn
                 245                 250                 255

 gac gag ctt cca aac tgc tgg gag tgt ccg aag tgt aac cac gcc ggc      816
 Asp Glu Leu Pro Asn Cys Trp Glu Cys Pro Lys Cys Asn His Ala Gly
             260                 265                 270

 aag acc ggg aaa caa aag cgt ggc cct ggc ttt aag tac gcc tcc aac      864
 Lys Thr Gly Lys Gln Lys Arg Gly Pro Gly Phe Lys Tyr Ala Ser Asn
         275                 280                 285

 ctg ccc ggc tcc ctg ctc aag gag cag aag atg aac cgg gac aac aag      912
 Leu Pro Gly Ser Leu Leu Lys Glu Gln Lys Met Asn Arg Asp Asn Lys
     290                 295                 300

 gaa ggg cag gaa cct gcc aag cgg agg agt gag tgt gag gag gcg ccc      960
 Glu Gly Gln Glu Pro Ala Lys Arg Arg Ser Glu Cys Glu Glu Ala Pro
 305                 310                 315                 320

 cgg cgc agg tcg gat gag cac tcg aag aag gtg ccg ccg gac ggc ctt     1008
 Arg Arg Arg Ser Asp Glu His Ser Lys Lys Val Pro Pro Asp Gly Leu
                 325                 330                 335

 ctg cgc aga aag tct gac gac gtg cac ctg agg aag aag cgg aaa tac     1056
 Leu Arg Arg Lys Ser Asp Asp Val His Leu Arg Lys Lys Arg Lys Tyr
             340                 345                 350

 gag aag ccc cag gag ctg agt gga cgc aag cgg cgg cgg tcc tgg aag     1104
 Glu Lys Pro Gln Glu Leu Ser Gly Arg Lys Arg Arg Arg Ser Trp Lys
         355                 360                 365

 aac gcc gag gac cgc atg gcg ctg gcc aac aag ccc ctc cgg cgc ttc     1152
 Asn Ala Glu Asp Arg Met Ala Leu Ala Asn Lys Pro Leu Arg Arg Phe
     370                 375                 380

 aag cag gaa ccc gag gac gaa ctg ccc gag gcg ccc ccc aag acc agg     1200
 Lys Gln Glu Pro Glu Asp Glu Leu Pro Glu Ala Pro Pro Lys Thr Arg
 385                 390                 395                 400

 gag agc gac cac tcc cgc tcc agc tcc ccc acc gcg gga ccc agc acc     1248
 Glu Ser Asp His Ser Arg Ser Ser Ser Pro Thr Ala Gly Pro Ser Thr
                 405                 410                 415

 gaa ggg gcc gag ggc ccg gag gag aag aag aag gtg aag atg cgc cgg     1296
 Glu Gly Ala Glu Gly Pro Glu Glu Lys Lys Lys Val Lys Met Arg Arg
             420                 425                 430

 aag cgg cgg ctt ccc aac aag gag ctg agc agg gag ctg agc aag gag     1344
 Lys Arg Arg Leu Pro Asn Lys Glu Leu Ser Arg Glu Leu Ser Lys Glu
         435                 440                 445

 ctc aac cac gag atc cag agg acg gag aac agc ctg gcc aac gag aac     1392
 Leu Asn His Glu Ile Gln Arg Thr Glu Asn Ser Leu Ala Asn Glu Asn
     450                 455                 460

 cag cag ccc atc aag tcg gag cct gag agc gag ggc gag gag ccc aag     1440
 Gln Gln Pro Ile Lys Ser Glu Pro Glu Ser Glu Gly Glu Glu Pro Lys
 465                 470                 475                 480

 cgg ccc ccg ggc atc tgc gag cgt ccc cac cgc ttc agc aag ggg ctc     1488
 Arg Pro Pro Gly Ile Cys Glu Arg Pro His Arg Phe Ser Lys Gly Leu
                 485                 490                 495

 aac ggc acc ccc cgg gag ctg cgg cac cag ctg ggg ccc agc ctg cgc     1536
 Asn Gly Thr Pro Arg Glu Leu Arg His Gln Leu Gly Pro Ser Leu Arg
             500                 505                 510

 agc ccg ccc cgt gtc atc tcc cgg ccc cca ccc tcc gtg tcc ccg ccc     1584
 Ser Pro Pro Arg Val Ile Ser Arg Pro Pro Pro Ser Val Ser Pro Pro
         515                 520                 525

 aag tgt atc cag atg gag cgc cat gtg atc cgg cca ccc ccc atc agc     1632
 Lys Cys Ile Gln Met Glu Arg His Val Ile Arg Pro Pro Pro Ile Ser
     530                 535                 540

 ccc ccg cct gac tcg cta ccc ctg gac gat ggg gca gcc cac gtc atg     1680
 Pro Pro Pro Asp Ser Leu Pro Leu Asp Asp Gly Ala Ala His Val Met
 545                 550                 555                 560

 cac agg gag gtg tgg atg gcc gtc ttc agc tac ctc agc cac caa gac     1728
 His Arg Glu Val Trp Met Ala Val Phe Ser Tyr Leu Ser His Gln Asp
                 565                 570                 575

 ctg tgt gtg tgc atg cgg gtc tgc agg acc tgg aac cgc tgg tgc tgc     1776
 Leu Cys Val Cys Met Arg Val Cys Arg Thr Trp Asn Arg Trp Cys Cys
             580                 585                 590

 gat aag cgg ttg tgg acc cgc att gac ctg aac cac tgc aag tct atc     1824
 Asp Lys Arg Leu Trp Thr Arg Ile Asp Leu Asn His Cys Lys Ser Ile
         595                 600                 605

 aca ccc ctg atg ctg agt ggc atc atc cgg cga cag ccc gtc tcc ctc     1872
 Thr Pro Leu Met Leu Ser Gly Ile Ile Arg Arg Gln Pro Val Ser Leu
     610                 615                 620

 gac ctc agc tgg acc aat atc tcc aag aag cag ctg agc tgg ctc atc     1920
 Asp Leu Ser Trp Thr Asn Ile Ser Lys Lys Gln Leu Ser Trp Leu Ile
 625                 630                 635                 640

 aac cgg ctg cct ggg ctc cgg gac ttg gtg ctg tca ggc tgc tca tgg     1968
 Asn Arg Leu Pro Gly Leu Arg Asp Leu Val Leu Ser Gly Cys Ser Trp
                 645                 650                 655

 atc gcg gtc tcg gcc ctt tgc agc tcc agt tgt ccg ctg ctc cgg acc     2016
 Ile Ala Val Ser Ala Leu Cys Ser Ser Ser Cys Pro Leu Leu Arg Thr
             660                 665                 670

 ctg gat gtc cag tgg gtg gag gga cta aag gat gcc cag atg cgg gat     2064
 Leu Asp Val Gln Trp Val Glu Gly Leu Lys Asp Ala Gln Met Arg Asp
         675                 680                 685

 ctc ctg tcc ccg ccc aca gac aac agg cca ggt cag atg gac aat cgg     2112
 Leu Leu Ser Pro Pro Thr Asp Asn Arg Pro Gly Gln Met Asp Asn Arg
     690                 695                 700

 agc aag ctc cgg aac atc gtg gag ctg cgc ctg gca ggc ctg gac atc     2160
 Ser Lys Leu Arg Asn Ile Val Glu Leu Arg Leu Ala Gly Leu Asp Ile
 705                 710                 715                 720

 aca gat gcc tcc ctg cgg ctc atc atc cgc cac atg ccc ctg ctc tcc     2208
 Thr Asp Ala Ser Leu Arg Leu Ile Ile Arg His Met Pro Leu Leu Ser
                 725                 730                 735

 aag ctc cac ctc agt tac tgt aac cac gtc acc gac cag tct atc aac     2256
 Lys Leu His Leu Ser Tyr Cys Asn His Val Thr Asp Gln Ser Ile Asn
             740                 745                 750

 ctg ctc act gct gtt ggc acc acc acc cga gac tcc tta acc gag atc     2304
 Leu Leu Thr Ala Val Gly Thr Thr Thr Arg Asp Ser Leu Thr Glu Ile
         755                 760                 765

 aac ctg tct gac tgc aat aag gtc act gat cag tgc ctg tcc ttc ttc     2352
 Asn Leu Ser Asp Cys Asn Lys Val Thr Asp Gln Cys Leu Ser Phe Phe
     770                 775                 780

 aaa cgc tgt gga aac atc tgt cat att gac ctg agg tac tgc aag caa     2400
 Lys Arg Cys Gly Asn Ile Cys His Ile Asp Leu Arg Tyr Cys Lys Gln
 785                 790                 795                 800

 gtc acc aag gaa ggc tgt gag cag ttc ata gcc gag atg tct aaa gca     2448
 Val Thr Lys Glu Gly Cys Glu Gln Phe Ile Ala Glu Met Ser Lys Ala
                 805                 810                 815

 agc aag ctg ttt ctg gct agt aaa ggt aac ggg aaa gag cta tac tct     2496
 Ser Lys Leu Phe Leu Ala Ser Lys Gly Asn Gly Lys Glu Leu Tyr Ser
             820                 825                 830

 gac aac ggc cac gcg tag                                             2514
 Asp Asn Gly His Ala 
         835





      <210> 696
      <211> 750
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (1)..(750)

      <400> 696
  atg ggg cct ttt aag aga agg ccg att agc cca tgg ttg ctt ttt tta      48
  Met Gly Pro Phe Lys Arg Arg Pro Ile Ser Pro Trp Leu Leu Phe Leu
    1               5                  10                  15

 atg gac tgc ttt ctc tcc ctc ttt ctc tgg cat tca gat gtg gag tac       96
 Met Asp Cys Phe Leu Ser Leu Phe Leu Trp His Ser Asp Val Glu Tyr
              20                  25                  30

 tcg gat gac cac tgc cat ttg att tta cca gat tcg gaa gca ttc caa      144
 Ser Asp Asp His Cys His Leu Ile Leu Pro Asp Ser Glu Ala Phe Gln
          35                  40                  45

 gat gtg caa gga aag aga cat cga ggg aag cac aag ttc aaa gta aaa      192
 Asp Val Gln Gly Lys Arg His Arg Gly Lys His Lys Phe Lys Val Lys
      50                  55                  60

 gaa atg tat ctg aca aag ctg ctg tcg acc aag ctc tgc cag tta acc      240
 Glu Met Tyr Leu Thr Lys Leu Leu Ser Thr Lys Leu Cys Gln Leu Thr
  65                  70                  75                  80

 ctt tct tct tct ctc caa gtg acg ctt ctg tct gtt gct tgc ctt cct      288
 Leu Ser Ser Ser Leu Gln Val Thr Leu Leu Ser Val Ala Cys Leu Pro
                  85                  90                  95

 ctt cgc ttc tgg gta aac atc ctg aag aac cct cag ttt gtc ttt gac      336
 Leu Arg Phe Trp Val Asn Ile Leu Lys Asn Pro Gln Phe Val Phe Asp
             100                 105                 110

 att aag aag aca cca cat ata gac ggc tgt ttg tca gtg att gcc cag      384
 Ile Lys Lys Thr Pro His Ile Asp Gly Cys Leu Ser Val Ile Ala Gln
         115                 120                 125

 gca ttc atg gat gca ttt tct ctc aca gag cag caa cta ggg aag gaa      432
 Ala Phe Met Asp Ala Phe Ser Leu Thr Glu Gln Gln Leu Gly Lys Glu
     130                 135                 140

 gca cca act aat aag ctt ctc tat gcc aag gat atc cca acc tac aaa      480
 Ala Pro Thr Asn Lys Leu Leu Tyr Ala Lys Asp Ile Pro Thr Tyr Lys
 145                 150                 155                 160

 gaa gaa gta aaa tct tat tac aaa gca atc agg gat ttg cct cca ttg      528
 Glu Glu Val Lys Ser Tyr Tyr Lys Ala Ile Arg Asp Leu Pro Pro Leu
                 165                 170                 175

 tca tcc tca gaa atg gaa gaa ttt tta act cag gaa tct aag aaa cat      576
 Ser Ser Ser Glu Met Glu Glu Phe Leu Thr Gln Glu Ser Lys Lys His
             180                 185                 190

 gaa aat gaa ttt aat gaa gaa gtg gcc ttg aca gaa att tac aaa tac      624
 Glu Asn Glu Phe Asn Glu Glu Val Ala Leu Thr Glu Ile Tyr Lys Tyr
         195                 200                 205

 atc gta aaa tat ttt gat gag att cta aat aaa cta gaa aga gaa cga      672
 Ile Val Lys Tyr Phe Asp Glu Ile Leu Asn Lys Leu Glu Arg Glu Arg
     210                 215                 220

 ggg ctg gaa gaa gct cag aaa caa ctc ttg cat gta aaa gtc tta ttt      720
 Gly Leu Glu Glu Ala Gln Lys Gln Leu Leu His Val Lys Val Leu Phe
 225                 230                 235                 240

 gat gaa aag aag aaa tgc aag tgg atg taa                              750
 Asp Glu Lys Lys Lys Cys Lys Trp Met 
                 245





      <210> 697
      <211> 1349
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (66)..(1349)

      <400> 697
 cttccagaag ctcccctcat gtgggtgtgg ctcaggaatg cctttctcaa tcttcaaagc     60

 cagcg    atg gct ggt caa gtt cct ctc aca cca cat tac tgt gac ctc     107
          Met Ala Gly Gln Val Pro Leu Thr Pro His Tyr Cys Asp Leu
            1               5                  10

 ctt tta tgc ctc cta att tca ctt tta agt act ctt gtg att act ctt      155
 Leu Leu Cys Leu Leu Ile Ser Leu Leu Ser Thr Leu Val Ile Thr Leu
  15                  20                  25                  30

 gtc cca tcc agt gat gca ttt gat ttt gag att ggc gtg gtt ata gtc      203
 Val Pro Ser Ser Asp Ala Phe Asp Phe Glu Ile Gly Val Val Ile Val
                  35                  40                  45

 aga atc agc caa gga ttt gac atc tct cag gtt ctt cag gtg caa gag      251
 Arg Ile Ser Gln Gly Phe Asp Ile Ser Gln Val Leu Gln Val Gln Glu
              50                  55                  60

 gaa tta gag aga tta gaa cag gag aga cta gca ttg gaa gcg act atc      299
 Glu Leu Glu Arg Leu Glu Gln Glu Arg Leu Ala Leu Glu Ala Thr Ile
          65                  70                  75

 aaa gat aat gag tgt gaa gag gaa agt gga ggc atc cga ggc ttg ttt      347
 Lys Asp Asn Glu Cys Glu Glu Glu Ser Gly Gly Ile Arg Gly Leu Phe
      80                  85                  90

 aaa aaa gct ggc aag ttg aac att act aag aca acg cct aaa aaa gat      395
 Lys Lys Ala Gly Lys Leu Asn Ile Thr Lys Thr Thr Pro Lys Lys Asp
  95                 100                 105                 110

 ggc agc att aac aca agc cag tcg atg cat gtg gga gag ttc aac cag      443
 Gly Ser Ile Asn Thr Ser Gln Ser Met His Val Gly Glu Phe Asn Gln
                 115                 120                 125

 aaa ctg gtg gaa gcc agc act caa ttt aaa aag aaa caa gaa aaa ggc      491
 Lys Leu Val Glu Ala Ser Thr Gln Phe Lys Lys Lys Gln Glu Lys Gly
             130                 135                 140

 aca att gat gtt tgg tgg ttg ttt gat gat gga ggg tta aca ctt ctt      539
 Thr Ile Asp Val Trp Trp Leu Phe Asp Asp Gly Gly Leu Thr Leu Leu
         145                 150                 155

 atc ccc tat atc tta act ctc aga aaa aaa tgg aaa gac tgt aaa tta      587
 Ile Pro Tyr Ile Leu Thr Leu Arg Lys Lys Trp Lys Asp Cys Lys Leu
     160                 165                 170

 aga atc tat gtg gga ggg aag atc aac cgc att gaa gaa gaa aaa att      635
 Arg Ile Tyr Val Gly Gly Lys Ile Asn Arg Ile Glu Glu Glu Lys Ile
 175                 180                 185                 190

 gta atg gct tcc ctt ctg agc aaa ttt agg ata aaa ttt gca gac atc      683
 Val Met Ala Ser Leu Leu Ser Lys Phe Arg Ile Lys Phe Ala Asp Ile
                 195                 200                 205

 cat atc atc ggt gac atc aac att agg cca aac aaa gag agc tgg aaa      731
 His Ile Ile Gly Asp Ile Asn Ile Arg Pro Asn Lys Glu Ser Trp Lys
             210                 215                 220

 gtc ttt gaa gag atg att gaa cca tat cgt ctc cat gaa agc tgc aaa      779
 Val Phe Glu Glu Met Ile Glu Pro Tyr Arg Leu His Glu Ser Cys Lys
         225                 230                 235

 gat tta aca act gct gag aaa tta aaa aga gaa act ccg tgg aaa att      827
 Asp Leu Thr Thr Ala Glu Lys Leu Lys Arg Glu Thr Pro Trp Lys Ile
     240                 245                 250

 aca gat gca gaa ctg gaa gca gtc aag gaa aag agt tac cgc caa gtt      875
 Thr Asp Ala Glu Leu Glu Ala Val Lys Glu Lys Ser Tyr Arg Gln Val
 255                 260                 265                 270

 cga ctg aat gaa ctc tta cag gag cac tcc aga gct gct aat ctc att      923
 Arg Leu Asn Glu Leu Leu Gln Glu His Ser Arg Ala Ala Asn Leu Ile
                 275                 280                 285

 gtc ctt cca tgg aaa agc cac tgt cct tac aag agc tta caa ggc cct      971
 Val Leu Pro Trp Lys Ser His Cys Pro Tyr Lys Ser Leu Gln Gly Pro
             290                 295                 300

 acc cct gca ccc cat cca cct att tct gcg act tca aca cct aca act     1019
 Thr Pro Ala Pro His Pro Pro Ile Ser Ala Thr Ser Thr Pro Thr Thr
         305                 310                 315

 gtg tac gcc ttc ctc tgt cac tgt tca gac cac act ggc ctt ctt aca     1067
 Val Tyr Ala Phe Leu Cys His Cys Ser Asp His Thr Gly Leu Leu Thr
     320                 325                 330

 gtt aaa ggt tta gac aga caa gaa aac aag tta cac ata ata att aca     1115
 Val Lys Gly Leu Asp Arg Gln Glu Asn Lys Leu His Ile Ile Ile Thr
 335                 340                 345                 350

 aat tgt gaa aaa tac tgt gaa gga aat aaa gag aaa gtg ttg aga cag     1163
 Asn Cys Glu Lys Tyr Cys Glu Gly Asn Lys Glu Lys Val Leu Arg Gln
                 355                 360                 365

 gat aac tct gtt gac ctt gat gcc ctt tgt ggg cgg gaa ctg gag agg     1211
 Asp Asn Ser Val Asp Leu Asp Ala Leu Cys Gly Arg Glu Leu Glu Arg
             370                 375                 380

 ctc ctt tca ctc agc cca ctg tcg gcc act cct ccc aaa aga gag cct     1259
 Leu Leu Ser Leu Ser Pro Leu Ser Ala Thr Pro Pro Lys Arg Glu Pro
         385                 390                 395

 gcg agc aag cga gtg cag caa ccg gag aca aca ctg gaa ctg gcc cat     1307
 Ala Ser Lys Arg Val Gln Gln Pro Glu Thr Thr Leu Glu Leu Ala His
     400                 405                 410

 tac tcc tct ctg gca gga gca cgc tct gtg cag gcc cta tag             1349
 Tyr Ser Ser Leu Ala Gly Ala Arg Ser Val Gln Ala Leu 
 415                 420                 425





      <210> 698
      <211> 588
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (1)..(588)

      <400> 698
  atg agc agt gag tct ctg atg gta ctg aaa ggt ttc ctt ctc ctt tct      48
  Met Ser Ser Glu Ser Leu Met Val Leu Lys Gly Phe Leu Leu Leu Ser
    1               5                  10                  15

 agc gcc ctt tac cac tct ccc act gcc tcc tct ctg ctc ctg cag ctt       96
 Ser Ala Leu Tyr His Ser Pro Thr Ala Ser Ser Leu Leu Leu Gln Leu
              20                  25                  30

 gat cct att tcc ctc ttt ctc ctc aac cat cca gcc gaa att tat aaa      144
 Asp Pro Ile Ser Leu Phe Leu Leu Asn His Pro Ala Glu Ile Tyr Lys
          35                  40                  45

 gtg ctt gac gct tct ggg cca gtc att gag cta agc act ggg cag gac      192
 Val Leu Asp Ala Ser Gly Pro Val Ile Glu Leu Ser Thr Gly Gln Asp
      50                  55                  60

 aca gcc tca gac atg aat gag aac ccg ctg aaa aat ttt aag cta att      240
 Thr Ala Ser Asp Met Asn Glu Asn Pro Leu Lys Asn Phe Lys Leu Ile
  65                  70                  75                  80

 ctt att cta gaa gaa cac cct ggc aac aat ttg gaa ggt gga ttt gtg      288
 Leu Ile Leu Glu Glu His Pro Gly Asn Asn Leu Glu Gly Gly Phe Val
                  85                  90                  95

 ggg agc act att tac aat agc aaa gac aca gaa tca acc gag gtg tct      336
 Gly Ser Thr Ile Tyr Asn Ser Lys Asp Thr Glu Ser Thr Glu Val Ser
             100                 105                 110

 atc act cat gga ttg gat aaa gaa aat gtg att gga aaa gtc aat atc      384
 Ile Thr His Gly Leu Asp Lys Glu Asn Val Ile Gly Lys Val Asn Ile
         115                 120                 125

 aat aaa atg gtc ata ctg cct aaa gca att tac aga gac aat gct att      432
 Asn Lys Met Val Ile Leu Pro Lys Ala Ile Tyr Arg Asp Asn Ala Ile
     130                 135                 140

 tct gtc aaa tta cca gtg ata atg ttc aca gaa ctg gaa aaa aaa act      480
 Ser Val Lys Leu Pro Val Ile Met Phe Thr Glu Leu Glu Lys Lys Thr
 145                 150                 155                 160

 atg caa aaa ttc ata tgg aaa gaa gaa gga gcc caa gta gcc aag gca      528
 Met Gln Lys Phe Ile Trp Lys Glu Glu Gly Ala Gln Val Ala Lys Ala
                 165                 170                 175

 atc tta agc aaa aag aac aaa acc ata ggc atc aca cta tcc aac ttt      576
 Ile Leu Ser Lys Lys Asn Lys Thr Ile Gly Ile Thr Leu Ser Asn Phe
             180                 185                 190

 aaa gta cac taa                                                      588
 Lys Val His 
         195





      <210> 699
      <211> 915
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (1)..(915)

      <400> 699
  atg gag ccg cgg gcg ctc gtc acg gcg ctc agc ctc ggc ctc agc ctg      48
  Met Glu Pro Arg Ala Leu Val Thr Ala Leu Ser Leu Gly Leu Ser Leu
    1               5                  10                  15

 tgc tcc ctg ggg ctg ctc gtc acg gcc atc ttc acc gac cac tgg tac       96
 Cys Ser Leu Gly Leu Leu Val Thr Ala Ile Phe Thr Asp His Trp Tyr
              20                  25                  30

 gag acc gac ccc cgg cgc cac aag gag agc tgc gag cgc agc cgc gcg      144
 Glu Thr Asp Pro Arg Arg His Lys Glu Ser Cys Glu Arg Ser Arg Ala
          35                  40                  45

 ggc gcc gac ccc ccg gac cag aag aac cgc ctg atg ccg ctg tcg cac      192
 Gly Ala Asp Pro Pro Asp Gln Lys Asn Arg Leu Met Pro Leu Ser His
      50                  55                  60

 ctg ccg ctg cgg gac tcg ccc ccg ctg ggg cgc cgg ctg ctc ccg ggc      240
 Leu Pro Leu Arg Asp Ser Pro Pro Leu Gly Arg Arg Leu Leu Pro Gly
  65                  70                  75                  80

 ggc ccg ggg cgc gcc gac ccc gag tcc tgg cgc tcg ctc ctg ggg ctc      288
 Gly Pro Gly Arg Ala Asp Pro Glu Ser Trp Arg Ser Leu Leu Gly Leu
                  85                  90                  95

 ggc ggg ctg gac gcc gag tgc ggc cgg ccc ctc ttc gcc acc tac tcg      336
 Gly Gly Leu Asp Ala Glu Cys Gly Arg Pro Leu Phe Ala Thr Tyr Ser
             100                 105                 110

 ggc ctc tgg agg aag tgc tac ttc ctg ggc atc gac cgg gac atc gac      384
 Gly Leu Trp Arg Lys Cys Tyr Phe Leu Gly Ile Asp Arg Asp Ile Asp
         115                 120                 125

 acc ctc atc ctg aaa ggt att gcg cag cga tgc acg gcc atc aag tac      432
 Thr Leu Ile Leu Lys Gly Ile Ala Gln Arg Cys Thr Ala Ile Lys Tyr
     130                 135                 140

 cac ttt tct cag ccc atc cgc ttg cga aac att cct ttt aat tta acc      480
 His Phe Ser Gln Pro Ile Arg Leu Arg Asn Ile Pro Phe Asn Leu Thr
 145                 150                 155                 160

 aag acc ata cag caa gat gag tgg cac ctg ctt cgt aag tat ttc cag      528
 Lys Thr Ile Gln Gln Asp Glu Trp His Leu Leu Arg Lys Tyr Phe Gln
                 165                 170                 175

 gag agt tac gct ccg cac atg aat tgc ctg gca acc cat aac cag atc      576
 Glu Ser Tyr Ala Pro His Met Asn Cys Leu Ala Thr His Asn Gln Ile
             180                 185                 190

 ata gac tct ttc aag gag gaa tct gtg cct tgt ccc ggt gct cag ccc      624
 Ile Asp Ser Phe Lys Glu Glu Ser Val Pro Cys Pro Gly Ala Gln Pro
         195                 200                 205

 acc cag tgc ctg gta gac caa ggg gaa cct aag gag tgt gac atc agc      672
 Thr Gln Cys Leu Val Asp Gln Gly Glu Pro Lys Glu Cys Asp Ile Ser
     210                 215                 220

 cct tcc aaa aat cta tac cct tac tcc atg gat cag aaa gcc att atg      720
 Pro Ser Lys Asn Leu Tyr Pro Tyr Ser Met Asp Gln Lys Ala Ile Met
 225                 230                 235                 240

 ggt att ctg caa ttg ctg agg gta gct att cca gct ata gac tca gac      768
 Gly Ile Leu Gln Leu Leu Arg Val Ala Ile Pro Ala Ile Asp Ser Asp
                 245                 250                 255

 act ggg ttc atc tgt gtg act gtc ctt gga att gaa agg gat gtt gct      816
 Thr Gly Phe Ile Cys Val Thr Val Leu Gly Ile Glu Arg Asp Val Ala
             260                 265                 270

 ctc ttt aca atc tgt aag gcg cct gtg gtg atc ttc act aag caa caa      864
 Leu Phe Thr Ile Cys Lys Ala Pro Val Val Ile Phe Thr Lys Gln Gln
         275                 280                 285

 tac aat ggt tcc gcc aac atg aag cac tct gtg aca aaa aaa aaa tgg      912
 Tyr Asn Gly Ser Ala Asn Met Lys His Ser Val Thr Lys Lys Lys Trp
     290                 295                 300

 taa                                                                  915
 






      <210> 700
      <211> 1029
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (1)..(1029)

      <400> 700
  atg gca gaa gtg aca ctg tgt gac atc caa ggc aag att aga caa ggc      48
  Met Ala Glu Val Thr Leu Cys Asp Ile Gln Gly Lys Ile Arg Gln Gly
    1               5                  10                  15

 atg cag ctg gcc tgg tgg ctt ctc ttg gcc att tgc tct ggg agc ctt       96
 Met Gln Leu Ala Trp Trp Leu Leu Leu Ala Ile Cys Ser Gly Ser Leu
              20                  25                  30

 cag ctg cca tca aag aag ttt ggc ttt cat gaa gaa ggc cac cat atg      144
 Gln Leu Pro Ser Lys Lys Phe Gly Phe His Glu Glu Gly His His Met
          35                  40                  45

 gag aag acc ata caa aga gat cat atg gag aga ttt aaa agc tgt ggg      192
 Glu Lys Thr Ile Gln Arg Asp His Met Glu Arg Phe Lys Ser Cys Gly
      50                  55                  60

 gct gca act agg gag agg caa ggg ccg ctc ccg gac gcc cca tcc gcc      240
 Ala Ala Thr Arg Glu Arg Gln Gly Pro Leu Pro Asp Ala Pro Ser Ala
  65                  70                  75                  80

 gtt acg tgg tcc cgg gat gtg cgg gtt gcg gta gag agt ggg cag caa      288
 Val Thr Trp Ser Arg Asp Val Arg Val Ala Val Glu Ser Gly Gln Gln
                  85                  90                  95

 tgc tcc tgg tcc tgc gtt ctc gcc tta gcc gcg ggg acc ccg agg cga      336
 Cys Ser Trp Ser Cys Val Leu Ala Leu Ala Ala Gly Thr Pro Arg Arg
             100                 105                 110

 gcc gct aat tgg tac cgg tgc ccc gtc cct cac ccc tgg cac cgg cgc      384
 Ala Ala Asn Trp Tyr Arg Cys Pro Val Pro His Pro Trp His Arg Arg
         115                 120                 125

 cct ttt aac cgc cgc tcc cgt tgg tgg gag cac gtt ggt ctt gtc tct      432
 Pro Phe Asn Arg Arg Ser Arg Trp Trp Glu His Val Gly Leu Val Ser
     130                 135                 140

 ccc tta gtc tcc tca ccc ccc gcg ctg atg ggc gtc ttt gtc tgc gat      480
 Pro Leu Val Ser Ser Pro Pro Ala Leu Met Gly Val Phe Val Cys Asp
 145                 150                 155                 160

 ttg gca gcc cca gga tgc cgg atg tta cca ggg aag cga tgt ttg gga      528
 Leu Ala Ala Pro Gly Cys Arg Met Leu Pro Gly Lys Arg Cys Leu Gly
                 165                 170                 175

 gac gct ttg tgt ctt gcg gag ttg cgc gtt tgt tgg gtg tgt cat cga      576
 Asp Ala Leu Cys Leu Ala Glu Leu Arg Val Cys Trp Val Cys His Arg
             180                 185                 190

 gat ctc aca aag tca atg aaa atc ctg tcc ctg aga ggg cag ctg aga      624
 Asp Leu Thr Lys Ser Met Lys Ile Leu Ser Leu Arg Gly Gln Leu Arg
         195                 200                 205

 aat ggc aga cat gtt ttg tac tat cac ctc cga cag cag ttg gct gag      672
 Asn Gly Arg His Val Leu Tyr Tyr His Leu Arg Gln Gln Leu Ala Glu
     210                 215                 220

 aga ggt gac gga gct gca gaa aaa atg ttg gaa gct agc aga ggt tgg      720
 Arg Gly Asp Gly Ala Ala Glu Lys Met Leu Glu Ala Ser Arg Gly Trp
 225                 230                 235                 240

 ttc atg agg ttt aat gaa aga agc cat ctg tat gac ata aaa gtg caa      768
 Phe Met Arg Phe Asn Glu Arg Ser His Leu Tyr Asp Ile Lys Val Gln
                 245                 250                 255

 ggt gaa gca gca agt gct cat gta gag cct tca gaa agc tat cca gaa      816
 Gly Glu Ala Ala Ser Ala His Val Glu Pro Ser Glu Ser Tyr Pro Glu
             260                 265                 270

 gat cta gct aag atc att aat gaa gac aaa aat cgg gcc ctg cat gca      864
 Asp Leu Ala Lys Ile Ile Asn Glu Asp Lys Asn Arg Ala Leu His Ala
         275                 280                 285

 gca gag cgc ttg caa acc aag ctg cga gaa cgt ggg gat gta gca aat      912
 Ala Glu Arg Leu Gln Thr Lys Leu Arg Glu Arg Gly Asp Val Ala Asn
     290                 295                 300

 gaa gac aaa ctg agc ctt ctg aag tca gtc ctg cag agc cct ctc ttc      960
 Glu Asp Lys Leu Ser Leu Leu Lys Ser Val Leu Gln Ser Pro Leu Phe
 305                 310                 315                 320

 agt cag att ctg agc ctt cag act tct gta cag cag ctg aaa gac cag     1008
 Ser Gln Ile Leu Ser Leu Gln Thr Ser Val Gln Gln Leu Lys Asp Gln
                 325                 330                 335

 ctt ttt gat tcg gat gct tag                                         1029
 Leu Phe Asp Ser Asp Ala 
             340





      <210> 701
      <211> 1533
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (1)..(1533)

      <400> 701
  atg gct cta ttt gca gtc ttt cag aca aca ttc ttc tta aca ttg ctg      48
  Met Ala Leu Phe Ala Val Phe Gln Thr Thr Phe Phe Leu Thr Leu Leu
    1               5                  10                  15

 tcc ttg agg act tac cag agt gaa gtc ttg gct gaa cgt tta cca ttg       96
 Ser Leu Arg Thr Tyr Gln Ser Glu Val Leu Ala Glu Arg Leu Pro Leu
              20                  25                  30

 act cct gta tca ctt aaa gtt tcc acc aat tct acg cgt cag agt ttg      144
 Thr Pro Val Ser Leu Lys Val Ser Thr Asn Ser Thr Arg Gln Ser Leu
          35                  40                  45

 cac tta caa tgg act gtc cac aac ctt cct tat cat cag gaa ttg aaa      192
 His Leu Gln Trp Thr Val His Asn Leu Pro Tyr His Gln Glu Leu Lys
      50                  55                  60

 atg gta ttt cag atc cag atc agt agg att gaa aca tcc aat gtc atc      240
 Met Val Phe Gln Ile Gln Ile Ser Arg Ile Glu Thr Ser Asn Val Ile
  65                  70                  75                  80

 tgg gtg ggg aat tac agc acc act gtg aag tgg aac cag gtt ctg cat      288
 Trp Val Gly Asn Tyr Ser Thr Thr Val Lys Trp Asn Gln Val Leu His
                  85                  90                  95

 tgg agc tgg gaa tct gag ctc cct ttg gaa tgt gcc aca cac ttt gta      336
 Trp Ser Trp Glu Ser Glu Leu Pro Leu Glu Cys Ala Thr His Phe Val
             100                 105                 110

 aga ata aag agt ttg gtg gac gat gcc aag ttc cct gag cca aat ttc      384
 Arg Ile Lys Ser Leu Val Asp Asp Ala Lys Phe Pro Glu Pro Asn Phe
         115                 120                 125

 tgg agc aac tgg agt tcc tgg gag gaa gtc agt gat aag ctg gtg gaa      432
 Trp Ser Asn Trp Ser Ser Trp Glu Glu Val Ser Asp Lys Leu Val Glu
     130                 135                 140

 gaa ggc acc aat gtt acc att tgt tac gtt tct agg aac att caa aat      480
 Glu Gly Thr Asn Val Thr Ile Cys Tyr Val Ser Arg Asn Ile Gln Asn
 145                 150                 155                 160

 aat gta tcc tgt tat ttg gaa ggg aaa cag att cat gga gaa caa ctt      528
 Asn Val Ser Cys Tyr Leu Glu Gly Lys Gln Ile His Gly Glu Gln Leu
                 165                 170                 175

 gat cca cat gta act gca ttc aac ttg aat agt gtg cct ttc att agg      576
 Asp Pro His Val Thr Ala Phe Asn Leu Asn Ser Val Pro Phe Ile Arg
             180                 185                 190

 aat aaa ggg aca aat atc tat tgt gag gca agt caa gga aat gtc agt      624
 Asn Lys Gly Thr Asn Ile Tyr Cys Glu Ala Ser Gln Gly Asn Val Ser
         195                 200                 205

 gaa ggc atg aaa ggc atc gtt ctt ttt gtc tca agc ctc tgg act aac      672
 Glu Gly Met Lys Gly Ile Val Leu Phe Val Ser Ser Leu Trp Thr Asn
     210                 215                 220

 aga gaa ctg cct gga gtc ttt aga gag gta cca ttc aag acc aca tgg      720
 Arg Glu Leu Pro Gly Val Phe Arg Glu Val Pro Phe Lys Thr Thr Trp
 225                 230                 235                 240

 agc tcc aca ggc ctt gga tcc ctg agc aac ctg gtg cta gct gct gta      768
 Ser Ser Thr Gly Leu Gly Ser Leu Ser Asn Leu Val Leu Ala Ala Val
                 245                 250                 255

 gcc cca ata gcg gcc att gcc acg ctc ctg aac cca aat gga aac tca      816
 Ala Pro Ile Ala Ala Ile Ala Thr Leu Leu Asn Pro Asn Gly Asn Ser
             260                 265                 270

 gaa atg aca gat aaa gaa ttt aag gca tca att gta agg agg ctc gaa      864
 Glu Met Thr Asp Lys Glu Phe Lys Ala Ser Ile Val Arg Arg Leu Glu
         275                 280                 285

 gag atc caa gac aaa gtt gaa aat caa cat gaa gaa act tct aag tca      912
 Glu Ile Gln Asp Lys Val Glu Asn Gln His Glu Glu Thr Ser Lys Ser
     290                 295                 300

 gat cca gaa atg cca gcc aag agc caa ggc ctg gaa tca gag acc cca      960
 Asp Pro Glu Met Pro Ala Lys Ser Gln Gly Leu Glu Ser Glu Thr Pro
 305                 310                 315                 320

 aga gcc cac ttg tgc tct acc cct gtc tcc aat gac tct ttc agt gat     1008
 Arg Ala His Leu Cys Ser Thr Pro Val Ser Asn Asp Ser Phe Ser Asp
                 325                 330                 335

 atg atg tca aag cca ggt act gtg agt gcc tac ttg act ttt cag tct     1056
 Met Met Ser Lys Pro Gly Thr Val Ser Ala Tyr Leu Thr Phe Gln Ser
             340                 345                 350

 tat gaa gtt tat tta atg aat cct ttt agt gtc aac ttt gaa aat gta     1104
 Tyr Glu Val Tyr Leu Met Asn Pro Phe Ser Val Asn Phe Glu Asn Val
         355                 360                 365

 aat gcc aca aat gcc atc atg acc tgg aag gtg cac tcc ata agg aat     1152
 Asn Ala Thr Asn Ala Ile Met Thr Trp Lys Val His Ser Ile Arg Asn
     370                 375                 380

 aat ttc aca tat ttg tgt cag att gaa ctc cat ggt gaa gga aaa atg     1200
 Asn Phe Thr Tyr Leu Cys Gln Ile Glu Leu His Gly Glu Gly Lys Met
 385                 390                 395                 400

 atg caa tac aat gtt tcc atc aag gtg aac ggt gag tac ttc tta agt     1248
 Met Gln Tyr Asn Val Ser Ile Lys Val Asn Gly Glu Tyr Phe Leu Ser
                 405                 410                 415

 gaa ctg gaa cct gcc aca gag tac atg gcg cga gta cgg tgt gct gat     1296
 Glu Leu Glu Pro Ala Thr Glu Tyr Met Ala Arg Val Arg Cys Ala Asp
             420                 425                 430

 gcc agc cac ttc tgg aaa tgg agt gaa tgg agt ggt cag aac ttc acc     1344
 Ala Ser His Phe Trp Lys Trp Ser Glu Trp Ser Gly Gln Asn Phe Thr
         435                 440                 445

 aca ctt gaa gct gac cac act agc atc cta gca atg gtt ctt aac ctg     1392
 Thr Leu Glu Ala Asp His Thr Ser Ile Leu Ala Met Val Leu Asn Leu
     450                 455                 460

 ttc aaa atg aca gaa tta gaa ttc aga ata tgg ata gaa aca aag atc     1440
 Phe Lys Met Thr Glu Leu Glu Phe Arg Ile Trp Ile Glu Thr Lys Ile
 465                 470                 475                 480

 atc aac atc caa gag aaa gtg aaa acc caa tcc aag gaa tct aag gaa     1488
 Ile Asn Ile Gln Glu Lys Val Lys Thr Gln Ser Lys Glu Ser Lys Glu
                 485                 490                 495

 tac aac aaa atg aca cag gag ata aaa gac aaa atg tcc att taa         1533
 Tyr Asn Lys Met Thr Gln Glu Ile Lys Asp Lys Met Ser Ile 
             500                 505                 510





      <210> 702
      <211> 840
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (1)..(840)

      <400> 702
  atg gtg cag ctg ctc cca agt tgg gca ggc ctt cgt tct ctg acc tgg      48
  Met Val Gln Leu Leu Pro Ser Trp Ala Gly Leu Arg Ser Leu Thr Trp
    1               5                  10                  15

 att ctt gct tca cag att cca agg aat gaa cct tgg ccc atg cgc tat       96
 Ile Leu Ala Ser Gln Ile Pro Arg Asn Glu Pro Trp Pro Met Arg Tyr
              20                  25                  30

 ggc aca gtg aac agg gcc atc aaa agc ctc tcc att ctt ctg gaa gct      144
 Gly Thr Val Asn Arg Ala Ile Lys Ser Leu Ser Ile Leu Leu Glu Ala
          35                  40                  45

 gca gag aaa ggg gac cca gaa acc tgg tat acc agc aaa aag ggg cag      192
 Ala Glu Lys Gly Asp Pro Glu Thr Trp Tyr Thr Ser Lys Lys Gly Gln
      50                  55                  60

 gaa tcc ttt gaa ggg ata aaa gaa gta atc aga gac ctg tcc atg gtg      240
 Glu Ser Phe Glu Gly Ile Lys Glu Val Ile Arg Asp Leu Ser Met Val
  65                  70                  75                  80

 aca ata ggg tca aga att gaa cag aca cag ttc aga ggc caa aag atc      288
 Thr Ile Gly Ser Arg Ile Glu Gln Thr Gln Phe Arg Gly Gln Lys Ile
                  85                  90                  95

 aaa gat tca gca aaa gaa ggc ccc gaa gtg cgt gct gat tcc aga aga      336
 Lys Asp Ser Ala Lys Glu Gly Pro Glu Val Arg Ala Asp Ser Arg Arg
             100                 105                 110

 gag gct gct tgt ctg ttt ggg aag aaa aac ctc cca act ctt gct tat      384
 Glu Ala Ala Cys Leu Phe Gly Lys Lys Asn Leu Pro Thr Leu Ala Tyr
         115                 120                 125

 gat ctc tgg tcc tat ctc ttt ttc tcc tgc ttc aag tct cca aaa gag      432
 Asp Leu Trp Ser Tyr Leu Phe Phe Ser Cys Phe Lys Ser Pro Lys Glu
     130                 135                 140

 ccc gaa cag ctg cag aag ctc ttt att gga gag ctg agc ttt gaa aca      480
 Pro Glu Gln Leu Gln Lys Leu Phe Ile Gly Glu Leu Ser Phe Glu Thr
 145                 150                 155                 160

 act gat gag agc ctg agg agc cat tct gag caa tgg gga atg ctc atg      528
 Thr Asp Glu Ser Leu Arg Ser His Ser Glu Gln Trp Gly Met Leu Met
                 165                 170                 175

 gac tgt gtg gtc atg aga gat ccg aac acc aag tgc tcc agg ggc ttt      576
 Asp Cys Val Val Met Arg Asp Pro Asn Thr Lys Cys Ser Arg Gly Phe
             180                 185                 190

 ggg ttt gtc aca tat gcc act gtg gag gag gtg gat gca gcc atg aat      624
 Gly Phe Val Thr Tyr Ala Thr Val Glu Glu Val Asp Ala Ala Met Asn
         195                 200                 205

 gca agg cca cac aag gtg gat gga aga gtt gtg gaa cca aag agc tgt      672
 Ala Arg Pro His Lys Val Asp Gly Arg Val Val Glu Pro Lys Ser Cys
     210                 215                 220

 ctc aag aga aga ttc tca aag acc agt ggc agc cgt ggt ggt gtt gaa      720
 Leu Lys Arg Arg Phe Ser Lys Thr Ser Gly Ser Arg Gly Gly Val Glu
 225                 230                 235                 240

 tat ggc agc agt ggg gat ggc tat aat gga ttt ggt aat gat gga agc      768
 Tyr Gly Ser Ser Gly Asp Gly Tyr Asn Gly Phe Gly Asn Asp Gly Ser
                 245                 250                 255

 aat ttt gga ggt ggt aaa agc tac agt gat ttg gca att ata aca atc      816
 Asn Phe Gly Gly Gly Lys Ser Tyr Ser Asp Leu Ala Ile Ile Thr Ile
             260                 265                 270

 agt ctt caa att ttg gac cct tga                                      840
 Ser Leu Gln Ile Leu Asp Pro 
         275





      <210> 703
      <211> 621
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (1)..(621)

      <400> 703
  atg ctg gcc ctc ctg tcc ccc ctg agc ctg gca cag tat gac agc tgg      48
  Met Leu Ala Leu Leu Ser Pro Leu Ser Leu Ala Gln Tyr Asp Ser Trp
    1               5                  10                  15

 ccc cat tac ccc gag tac ttc cag caa ccg gct cct gag tat cac cag       96
 Pro His Tyr Pro Glu Tyr Phe Gln Gln Pro Ala Pro Glu Tyr His Gln
              20                  25                  30

 ccc cag gcc ccc gcc aac gtg gcc aag att cag ctg cgc ctg gct ggg      144
 Pro Gln Ala Pro Ala Asn Val Ala Lys Ile Gln Leu Arg Leu Ala Gly
          35                  40                  45

 cag aag agg aag cac agc gag ggc cgg gtg gag gtg tac tat gat ggc      192
 Gln Lys Arg Lys His Ser Glu Gly Arg Val Glu Val Tyr Tyr Asp Gly
      50                  55                  60

 cag tgg ggc acc gtg tgc gat gac gac ttc tcc atc cac gct gcc cac      240
 Gln Trp Gly Thr Val Cys Asp Asp Asp Phe Ser Ile His Ala Ala His
  65                  70                  75                  80

 gtc gtc tgc cgg gag ctg ggc tac gtg gag gcc aag tcc tgg act gtc      288
 Val Val Cys Arg Glu Leu Gly Tyr Val Glu Ala Lys Ser Trp Thr Val
                  85                  90                  95

 agc tcc tcc tac ggc aag gga gaa ggg ccc atc tgg tta gac aat ctc      336
 Ser Ser Ser Tyr Gly Lys Gly Glu Gly Pro Ile Trp Leu Asp Asn Leu
             100                 105                 110

 cac tgt act ggc aac gag gcg acc ctt gca gca tgc acc tcc aat ggc      384
 His Cys Thr Gly Asn Glu Ala Thr Leu Ala Ala Cys Thr Ser Asn Gly
         115                 120                 125

 tgg ggc gtc act gac tgc aag cac acg gag gat gtc ggt gtg gtg tgc      432
 Trp Gly Val Thr Asp Cys Lys His Thr Glu Asp Val Gly Val Val Cys
     130                 135                 140

 agc gac aaa agg att cct ggg ttc aaa ttt gac aat tcg ttg atc aac      480
 Ser Asp Lys Arg Ile Pro Gly Phe Lys Phe Asp Asn Ser Leu Ile Asn
 145                 150                 155                 160

 cag ata gag gca agt cat gac cat gag ctg att tgt aac atc tta gat      528
 Gln Ile Glu Ala Ser His Asp His Glu Leu Ile Cys Asn Ile Leu Asp
                 165                 170                 175

 ggg cct ctg ttc aac ctg aac ctc agg ata atc tac ttg gag tgt cca      576
 Gly Pro Leu Phe Asn Leu Asn Leu Arg Ile Ile Tyr Leu Glu Cys Pro
             180                 185                 190

 gtg aag acc cag cct tct tgg cat aag aaa gtc att gat cat tga          621
 Val Lys Thr Gln Pro Ser Trp His Lys Lys Val Ile Asp His 
         195                 200                 205





      <210> 704
      <211> 357
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (1)..(357)

      <400> 704
  atg gtg cag ttt gat cac cgg att ctg cga ata tgt ttt gag ggt ctg      48
  Met Val Gln Phe Asp His Arg Ile Leu Arg Ile Cys Phe Glu Gly Leu
    1               5                  10                  15

 cta tgg gcc att caa aga ttg gct tgg agg cct gtg tgt gat gaa ttg       96
 Leu Trp Ala Ile Gln Arg Leu Ala Trp Arg Pro Val Cys Asp Glu Leu
              20                  25                  30

 gag cgg gga aag atg agc agt aag gag act gtg aga agc ata gtg ctg      144
 Glu Arg Gly Lys Met Ser Ser Lys Glu Thr Val Arg Ser Ile Val Leu
          35                  40                  45

 ctg cgt aat gcc agg gag agt gat gga gat ggg gcc tac atg gtg ggc      192
 Leu Arg Asn Ala Arg Glu Ser Asp Gly Asp Gly Ala Tyr Met Val Gly
      50                  55                  60

 ttg ggc atc agc acg ctg ctg atg tat gtc cca act cct ctg gcc gcc      240
 Leu Gly Ile Ser Thr Leu Leu Met Tyr Val Pro Thr Pro Leu Ala Ala
  65                  70                  75                  80

 act cac cag tca ggc tcc ttg gct ttg ctc act ggc ttt gtg tca ggt      288
 Thr His Gln Ser Gly Ser Leu Ala Leu Leu Thr Gly Phe Val Ser Gly
                  85                  90                  95

 ttt tca gtg ttg gca agc tct tgg ttc tac gtg gat gat ttc tac gtg      336
 Phe Ser Val Leu Ala Ser Ser Trp Phe Tyr Val Asp Asp Phe Tyr Val
             100                 105                 110

 gat gtt ctc ctg agt cct taa                                          357
 Asp Val Leu Leu Ser Pro 
         115





      <210> 705
      <211> 1680
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (1)..(1680)

      <400> 705
  atg ctg ttg ccg ctg ctg ctg ctg cta ccc atg tgc tgg gcc gtg gag      48
  Met Leu Leu Pro Leu Leu Leu Leu Leu Pro Met Cys Trp Ala Val Glu
    1               5                  10                  15

 gtc aag agg ccc cgg ggc gtc tcc ctc acc aat cat cac ttc tac gat       96
 Val Lys Arg Pro Arg Gly Val Ser Leu Thr Asn His His Phe Tyr Asp
              20                  25                  30

 gag tcc aag cct ttc acc tgc ctg gac ggt tcg gcc acc atc cca ttt      144
 Glu Ser Lys Pro Phe Thr Cys Leu Asp Gly Ser Ala Thr Ile Pro Phe
          35                  40                  45

 gat cag gtc aac gat gac tat tgc gac tgc aaa gat ggc tct gac gag      192
 Asp Gln Val Asn Asp Asp Tyr Cys Asp Cys Lys Asp Gly Ser Asp Glu
      50                  55                  60

 cca ggc acg gct gcc tgt cct aat ggc agc ttc cac tgc acc aac act      240
 Pro Gly Thr Ala Ala Cys Pro Asn Gly Ser Phe His Cys Thr Asn Thr
  65                  70                  75                  80

 ggc tat aag ccc ctg tat atc ccc tcc aac cgg gtc aac gat ggt gtt      288
 Gly Tyr Lys Pro Leu Tyr Ile Pro Ser Asn Arg Val Asn Asp Gly Val
                  85                  90                  95

 tgt gac tgc tgc gat gga aca gac gag tac aac agc ggc gtc atc tgt      336
 Cys Asp Cys Cys Asp Gly Thr Asp Glu Tyr Asn Ser Gly Val Ile Cys
             100                 105                 110

 gag aac acc tgc aag tac gtg ggt gac agt acc cct ccc atc acc cca      384
 Glu Asn Thr Cys Lys Tyr Val Gly Asp Ser Thr Pro Pro Ile Thr Pro
         115                 120                 125

 ccc caa gac ttt gcc tgg ctc cac cca gtg aat cgg gcc cac tct ctc      432
 Pro Gln Asp Phe Ala Trp Leu His Pro Val Asn Arg Ala His Ser Leu
     130                 135                 140

 ttc tgc ttt tct gta tcg ggt tct ctg tct gtg cca ggt gcc tta gag      480
 Phe Cys Phe Ser Val Ser Gly Ser Leu Ser Val Pro Gly Ala Leu Glu
 145                 150                 155                 160

 aag ggc cgt aag gag aga gag tcc ctg cag cag atg gcc gag gtc acc      528
 Lys Gly Arg Lys Glu Arg Glu Ser Leu Gln Gln Met Ala Glu Val Thr
                 165                 170                 175

 cgc gaa ggg ttc cgt ctg aag aag atc ctt att gag gac tgg aag aag      576
 Arg Glu Gly Phe Arg Leu Lys Lys Ile Leu Ile Glu Asp Trp Lys Lys
             180                 185                 190

 gca cgg gag gag aag cag aaa aag ctc att gag cta cag gct ggg aag      624
 Ala Arg Glu Glu Lys Gln Lys Lys Leu Ile Glu Leu Gln Ala Gly Lys
         195                 200                 205

 aag tct ctg gaa gac cag gtg gag atg ctg cgg aca gtg aag gag gaa      672
 Lys Ser Leu Glu Asp Gln Val Glu Met Leu Arg Thr Val Lys Glu Glu
     210                 215                 220

 gct gag aag cca gag aga gag gcc aaa gag cag cac cag aag ctg tgg      720
 Ala Glu Lys Pro Glu Arg Glu Ala Lys Glu Gln His Gln Lys Leu Trp
 225                 230                 235                 240

 gaa gag cag ctg gct gct gcc aag gcc caa cag gag cag gag ctg gcg      768
 Glu Glu Gln Leu Ala Ala Ala Lys Ala Gln Gln Glu Gln Glu Leu Ala
                 245                 250                 255

 gct gat gcc ttc aag gag ctg gat gat gac atg gac ggg act ggg gac      816
 Ala Asp Ala Phe Lys Glu Leu Asp Asp Asp Met Asp Gly Thr Gly Asp
             260                 265                 270

 aca cag aca gac gcc acc tct ttc tac gac cgc gtc tgg gcc gcc atc      864
 Thr Gln Thr Asp Ala Thr Ser Phe Tyr Asp Arg Val Trp Ala Ala Ile
         275                 280                 285

 agg gac aag tac cgg tcc gag gca ctg ccc acc gac ctt cca gca cct      912
 Arg Asp Lys Tyr Arg Ser Glu Ala Leu Pro Thr Asp Leu Pro Ala Pro
     290                 295                 300

 tct gcc cct gac ttg acg gag ccc aag gag gag cag ccg cca gtg ccc      960
 Ser Ala Pro Asp Leu Thr Glu Pro Lys Glu Glu Gln Pro Pro Val Pro
 305                 310                 315                 320

 tcg tcg ccc aca gag gag gag gag gag gag gag gag gag gag gaa gaa     1008
 Ser Ser Pro Thr Glu Glu Glu Glu Glu Glu Glu Glu Glu Glu Glu Glu
                 325                 330                 335

 gag gct gaa gaa gag gag gag gag gag gat tcc gag gtg cag ggg gag     1056
 Glu Ala Glu Glu Glu Glu Glu Glu Glu Asp Ser Glu Val Gln Gly Glu
             340                 345                 350

 cag ccc aag gag gcc cca ccg cca ctg tca ccc ccg cag ccg gcc agc     1104
 Gln Pro Lys Glu Ala Pro Pro Pro Leu Ser Pro Pro Gln Pro Ala Ser
         355                 360                 365

 cct gct gag gaa gac aaa atg ccg ccc tac gac gag cag acg cag gcc     1152
 Pro Ala Glu Glu Asp Lys Met Pro Pro Tyr Asp Glu Gln Thr Gln Ala
     370                 375                 380

 ttc atc gat gct gcc cag gag gcc cgc aac aag ttc gag gag gcc gag     1200
 Phe Ile Asp Ala Ala Gln Glu Ala Arg Asn Lys Phe Glu Glu Ala Glu
 385                 390                 395                 400

 cgg tcg ctg aag gac atg gag gag tcc atc agg aac ctg gag caa gag     1248
 Arg Ser Leu Lys Asp Met Glu Glu Ser Ile Arg Asn Leu Glu Gln Glu
                 405                 410                 415

 att tct ttt gac ttt ggc ccc aac ggg gag ttt gct tac ctg tac agc     1296
 Ile Ser Phe Asp Phe Gly Pro Asn Gly Glu Phe Ala Tyr Leu Tyr Ser
             420                 425                 430

 cag tgc tac gag ctc acc acc aac gag tgc gtc cca gga atg cag ggg     1344
 Gln Cys Tyr Glu Leu Thr Thr Asn Glu Cys Val Pro Gly Met Gln Gly
         435                 440                 445

 ccc cca ctg gca gga tac gtc tac cgc ctc tgc ccc ttc aag ctt gtc     1392
 Pro Pro Leu Ala Gly Tyr Val Tyr Arg Leu Cys Pro Phe Lys Leu Val
     450                 455                 460

 tcg cag aaa ccc aaa ctc ggg ggc tct ccc acc agc ctt ggc acc tgg     1440
 Ser Gln Lys Pro Lys Leu Gly Gly Ser Pro Thr Ser Leu Gly Thr Trp
 465                 470                 475                 480

 ggc tca tgg att ggc ccc gac cac gac aag ttc agt gcc atg aag tat     1488
 Gly Ser Trp Ile Gly Pro Asp His Asp Lys Phe Ser Ala Met Lys Tyr
                 485                 490                 495

 gag caa ggc acg ggc tgc tgg cag ggc ccc aac cgc tcc acc acc gtg     1536
 Glu Gln Gly Thr Gly Cys Trp Gln Gly Pro Asn Arg Ser Thr Thr Val
             500                 505                 510

 cgc ctc ctg tgc ggg aaa gag acc atg gtg acc agc acc aca gag ccc     1584
 Arg Leu Leu Cys Gly Lys Glu Thr Met Val Thr Ser Thr Thr Glu Pro
         515                 520                 525

 agt cgc tgc gag tac ctc atg gag ctg atg acg cca gcc gcc tgc ccg     1632
 Ser Arg Cys Glu Tyr Leu Met Glu Leu Met Thr Pro Ala Ala Cys Pro
     530                 535                 540

 gag cca ccg cct gaa gca ccc acc gaa gac gac cat gac gag ctc tag     1680
 Glu Pro Pro Pro Glu Ala Pro Thr Glu Asp Asp His Asp Glu Leu 
 545                 550                 555





      <210> 706
      <211> 717
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (1)..(717)

      <400> 706
  atg ggt ggt gtt cgg gct cca gcc aca aag cag ctc ctt gag gca cta      48
  Met Gly Gly Val Arg Ala Pro Ala Thr Lys Gln Leu Leu Glu Ala Leu
    1               5                  10                  15

 ttt ggt gtt gtc cgt agt ggt ttt aat ttg cat ttc tct gct gcc atg       96
 Phe Gly Val Val Arg Ser Gly Phe Asn Leu His Phe Ser Ala Ala Met
              20                  25                  30

 ctg aaa gtt ggt cct tta tgg tgt ctt gga gca ttt ctt ttg acc acc      144
 Leu Lys Val Gly Pro Leu Trp Cys Leu Gly Ala Phe Leu Leu Thr Thr
          35                  40                  45

 aag act ttt cat gta aat ata gtc gtg gac att tgc ttt gat att aca      192
 Lys Thr Phe His Val Asn Ile Val Val Asp Ile Cys Phe Asp Ile Thr
      50                  55                  60

 cca aaa gtt agt atg ggt cgt ttc tta aag gaa tct gta agc cca ggg      240
 Pro Lys Val Ser Met Gly Arg Phe Leu Lys Glu Ser Val Ser Pro Gly
  65                  70                  75                  80

 aag atg tca cgc tca cag tgg cag aca gaa gtt ttc cag act tcc cag      288
 Lys Met Ser Arg Ser Gln Trp Gln Thr Glu Val Phe Gln Thr Ser Gln
                  85                  90                  95

 aat act gga ccg tca ttc aga gct tgg ttt gaa ttt agc ttc atc cac      336
 Asn Thr Gly Pro Ser Phe Arg Ala Trp Phe Glu Phe Ser Phe Ile His
             100                 105                 110

 ttg cca gca ctg agt gat ttt cta aac ctc ttt ctt tat gtc tgt tgt      384
 Leu Pro Ala Leu Ser Asp Phe Leu Asn Leu Phe Leu Tyr Val Cys Cys
         115                 120                 125

 gct gtt ata aag att aaa tgg caa gaa agt gtc aat atg tgt aaa gtt      432
 Ala Val Ile Lys Ile Lys Trp Gln Glu Ser Val Asn Met Cys Lys Val
     130                 135                 140

 ttt agg atg atg tct ggc cca gat gtt cct cct gct gat caa gag aag      480
 Phe Arg Met Met Ser Gly Pro Asp Val Pro Pro Ala Asp Gln Glu Lys
 145                 150                 155                 160

 ctt ttt atc cag aag tta cgt cag tgt tgc gtc ctc ttt gac ttt gtt      528
 Leu Phe Ile Gln Lys Leu Arg Gln Cys Cys Val Leu Phe Asp Phe Val
                 165                 170                 175

 tct gat cca cta agt gac cta aag tgg aag gaa gta aaa cga gct gct      576
 Ser Asp Pro Leu Ser Asp Leu Lys Trp Lys Glu Val Lys Arg Ala Ala
             180                 185                 190

 tta agt gaa atg gta gaa tat atc acc cat aat cgg aat gtg atc aca      624
 Leu Ser Glu Met Val Glu Tyr Ile Thr His Asn Arg Asn Val Ile Thr
         195                 200                 205

 gag cct att tac cca gaa gta gtc cat atg aat cca aag ctt tat agt      672
 Glu Pro Ile Tyr Pro Glu Val Val His Met Asn Pro Lys Leu Tyr Ser
     210                 215                 220

 tgt tgt act cct gat gct gct act ttt aag tat cct gct tat tag          717
 Cys Cys Thr Pro Asp Ala Ala Thr Phe Lys Tyr Pro Ala Tyr 
 225                 230                 235





      <210> 707
      <211> 1424
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (126)..(1424)

      <400> 707
 ctggtttgca tccttttaca agctattgct tgctgcatga aaagaaattt aaagcagttg     60

 ttttaagtct tggggagggt ggttgtgatg gtgctgatgg tgctgatggt ggtgatggca    120

 gcggc    atg gca aaa tca gga ccc tta gct gca ggt ctg ttg gag ttt     167
          Met Ala Lys Ser Gly Pro Leu Ala Ala Gly Leu Leu Glu Phe
            1               5                  10

 gct gga ggt cca ctc cag acc ctg ttt gcc tgg gta tca gca gca gag      215
 Ala Gly Gly Pro Leu Gln Thr Leu Phe Ala Trp Val Ser Ala Ala Glu
  15                  20                  25                  30

 gct gca gaa cag cca ata ttg ctg aac agc aaa tgt tgc tgc ctg att      263
 Ala Ala Glu Gln Pro Ile Leu Leu Asn Ser Lys Cys Cys Cys Leu Ile
                  35                  40                  45

 gtt cct ctg gaa gct tcg tct tgg agg ggt acc cgg ccg tgt gag gtt      311
 Val Pro Leu Glu Ala Ser Ser Trp Arg Gly Thr Arg Pro Cys Glu Val
              50                  55                  60

 atc gtc agt gaa gca gga gca tca atc tac agt gtc agc cct gaa gct      359
 Ile Val Ser Glu Ala Gly Ala Ser Ile Tyr Ser Val Ser Pro Glu Ala
          65                  70                  75

 aac aaa gag atg cca ggg ctg gac cct aat ttg aga agt gca gtt tcc      407
 Asn Lys Glu Met Pro Gly Leu Asp Pro Asn Leu Arg Ser Ala Val Ser
      80                  85                  90

 ata gca agg cgt gta caa gat cca tta gct gag cta gtg aaa att gag      455
 Ile Ala Arg Arg Val Gln Asp Pro Leu Ala Glu Leu Val Lys Ile Glu
  95                 100                 105                 110

 cca aag cac att gga gtt gga atg tat cag cat gac gta tcc cag act      503
 Pro Lys His Ile Gly Val Gly Met Tyr Gln His Asp Val Ser Gln Thr
                 115                 120                 125

 tta ctc aag gca aca ctg gac agt gtt gta gaa gaa tgt gtc agc ttt      551
 Leu Leu Lys Ala Thr Leu Asp Ser Val Val Glu Glu Cys Val Ser Phe
             130                 135                 140

 gtg gga gtg gat att aac atc tgt tca gaa gtt ttg tta agg cat att      599
 Val Gly Val Asp Ile Asn Ile Cys Ser Glu Val Leu Leu Arg His Ile
         145                 150                 155

 gca gga ctc aat gcc aac agg gcc aaa aat att att gaa tgg cga gag      647
 Ala Gly Leu Asn Ala Asn Arg Ala Lys Asn Ile Ile Glu Trp Arg Glu
     160                 165                 170

 aaa aat gga ccc ttt atc aac cga gaa cag ctg aag aaa gtg aaa ggg      695
 Lys Asn Gly Pro Phe Ile Asn Arg Glu Gln Leu Lys Lys Val Lys Gly
 175                 180                 185                 190

 ctg ggc cca aaa tcc ttc caa cag tgt gct ggc ttc atc aga atc aac      743
 Leu Gly Pro Lys Ser Phe Gln Gln Cys Ala Gly Phe Ile Arg Ile Asn
                 195                 200                 205

 cag gat tat atc cga acg ttt tgc agt cag caa act gaa act tca ggc      791
 Gln Asp Tyr Ile Arg Thr Phe Cys Ser Gln Gln Thr Glu Thr Ser Gly
             210                 215                 220

 caa att caa gga gtt gct gtg aca tct tca gca gac gtt gag gtc aca      839
 Gln Ile Gln Gly Val Ala Val Thr Ser Ser Ala Asp Val Glu Val Thr
         225                 230                 235

 aat gag aag cag ggc aaa aag aag agc aaa act gca gtg aat gtt tta      887
 Asn Glu Lys Gln Gly Lys Lys Lys Ser Lys Thr Ala Val Asn Val Leu
     240                 245                 250

 ctg aag cca aat cct ttg gac caa act tgt att cat cca gaa tca tat      935
 Leu Lys Pro Asn Pro Leu Asp Gln Thr Cys Ile His Pro Glu Ser Tyr
 255                 260                 265                 270

 gac ata gca atg agg ttt ttg tca tcc att gga ggg aca ctg tat gag      983
 Asp Ile Ala Met Arg Phe Leu Ser Ser Ile Gly Gly Thr Leu Tyr Glu
                 275                 280                 285

 gtt gga aag cct gaa atg caa caa aaa ata aat tca ttc ctt gaa aag     1031
 Val Gly Lys Pro Glu Met Gln Gln Lys Ile Asn Ser Phe Leu Glu Lys
             290                 295                 300

 gaa gga atg gag aaa att gca gaa aga ttg caa aca aca gta cac acc     1079
 Glu Gly Met Glu Lys Ile Ala Glu Arg Leu Gln Thr Thr Val His Thr
         305                 310                 315

 tta cag gtc atc ata gat ggt ctc agc cag cct gaa agc ttt gac ttt     1127
 Leu Gln Val Ile Ile Asp Gly Leu Ser Gln Pro Glu Ser Phe Asp Phe
     320                 325                 330

 cga aca gat ttt gat aaa cct gat ttc aag aga agc ata gta tgc ctg     1175
 Arg Thr Asp Phe Asp Lys Pro Asp Phe Lys Arg Ser Ile Val Cys Leu
 335                 340                 345                 350

 gaa gat ctg cag att ggg aca gtt ctt aca ggc aaa gtt gag aat gcc     1223
 Glu Asp Leu Gln Ile Gly Thr Val Leu Thr Gly Lys Val Glu Asn Ala
                 355                 360                 365

 act ctc ttt gga att ttt gtg gat ata gga gtg ggg aaa tct ggg ctg     1271
 Thr Leu Phe Gly Ile Phe Val Asp Ile Gly Val Gly Lys Ser Gly Leu
             370                 375                 380

 att ccc ata cga aat gta aca gaa gca aaa ctt tca aaa aca aag aag     1319
 Ile Pro Ile Arg Asn Val Thr Glu Ala Lys Leu Ser Lys Thr Lys Lys
         385                 390                 395

 aga aga agc ctt gga ctg ggc ccc gga gaa aga gtg gaa gtc caa gta     1367
 Arg Arg Ser Leu Gly Leu Gly Pro Gly Glu Arg Val Glu Val Gln Val
     400                 405                 410

 ctc aac att gac atc ccc cga tct agg att act ctg gac ctc att cgg     1415
 Leu Asn Ile Asp Ile Pro Arg Ser Arg Ile Thr Leu Asp Leu Ile Arg
 415                 420                 425                 430

 gtg tta tga                                                         1424
 Val Leu 






      <210> 708
      <211> 963
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (1)..(963)

      <400> 708
  atg acc ctc ggc cgc cga ctc gcg tgt ctt ttc ctc gcc tgt gtc ctg      48
  Met Thr Leu Gly Arg Arg Leu Ala Cys Leu Phe Leu Ala Cys Val Leu
    1               5                  10                  15

 ccg gcc ttg ctg ctg ggg ggc acc gcg ctg gcc tcg gag att gtg ggg       96
 Pro Ala Leu Leu Leu Gly Gly Thr Ala Leu Ala Ser Glu Ile Val Gly
              20                  25                  30

 ggc cgg cga gcg cgg ccc cac gcg tgg ccc ttc atg gtg tcc ctg cag      144
 Gly Arg Arg Ala Arg Pro His Ala Trp Pro Phe Met Val Ser Leu Gln
          35                  40                  45

 ctg cgc gga ggc cac ttc tgc ggc gcc acc ctg att gcg ccc aac ttc      192
 Leu Arg Gly Gly His Phe Cys Gly Ala Thr Leu Ile Ala Pro Asn Phe
      50                  55                  60

 gtc atg tcg gcc gcg cac tgc gtg gcg aat gta aac gtc cgc gcg gtg      240
 Val Met Ser Ala Ala His Cys Val Ala Asn Val Asn Val Arg Ala Val
  65                  70                  75                  80

 cgg gtg gtc ctg gga gcc cat aac ctc tcg cgg cgg gag ccc acc cgg      288
 Arg Val Val Leu Gly Ala His Asn Leu Ser Arg Arg Glu Pro Thr Arg
                  85                  90                  95

 cag gtg ttc gcc gtg cag cgc atc ttc gaa aac ggc tac gac ccc gta      336
 Gln Val Phe Ala Val Gln Arg Ile Phe Glu Asn Gly Tyr Asp Pro Val
             100                 105                 110

 aac ttg ctc aac gac atc gtg att ctc cag gga ggc ccc gat ctg ctg      384
 Asn Leu Leu Asn Asp Ile Val Ile Leu Gln Gly Gly Pro Asp Leu Leu
         115                 120                 125

 tca atc aac aaa ctt act gag aag gga ggc ccc gat ctg ttg tca atc      432
 Ser Ile Asn Lys Leu Thr Glu Lys Gly Gly Pro Asp Leu Leu Ser Ile
     130                 135                 140

 aac aaa ctt act gag aag gga ggc ccc gat ctg ttg tca atc aac aaa      480
 Asn Lys Leu Thr Glu Lys Gly Gly Pro Asp Leu Leu Ser Ile Asn Lys
 145                 150                 155                 160

 ctt act gag aag gga ggc ccc gat ctg ctg tca atc aac aaa ctt act      528
 Leu Thr Glu Lys Gly Gly Pro Asp Leu Leu Ser Ile Asn Lys Leu Thr
                 165                 170                 175

 gag aag gga ggc ccc gat ctg ttg tca atc aac aaa ctt act gag aag      576
 Glu Lys Gly Gly Pro Asp Leu Leu Ser Ile Asn Lys Leu Thr Glu Lys
             180                 185                 190

 gga ggc ccc gat ctg ctg tca atc aac aaa ctt act gag aag gga ggc      624
 Gly Gly Pro Asp Leu Leu Ser Ile Asn Lys Leu Thr Glu Lys Gly Gly
         195                 200                 205

 ccc gat ctg ttg tca atc aac aaa ctt act gag aag gga ggc ccc gat      672
 Pro Asp Leu Leu Ser Ile Asn Lys Leu Thr Glu Lys Gly Gly Pro Asp
     210                 215                 220

 ctg ctg tca atc aac aaa ctt act gag aag gga ggc ccc gat ctg ttg      720
 Leu Leu Ser Ile Asn Lys Leu Thr Glu Lys Gly Gly Pro Asp Leu Leu
 225                 230                 235                 240

 tca atc aac aaa ctt act gag aag gga ggc ccc gat ctg ctg tca atc      768
 Ser Ile Asn Lys Leu Thr Glu Lys Gly Gly Pro Asp Leu Leu Ser Ile
                 245                 250                 255

 aac aaa ctt act gag att ctt tgt gtc tct cca ttc acc agt cct gtg      816
 Asn Lys Leu Thr Glu Ile Leu Cys Val Ser Pro Phe Thr Ser Pro Val
             260                 265                 270

 gcc cag ggc agg ggc cgc ctc tgt ctt tgg gaa aag ggg caa aag tcc      864
 Ala Gln Gly Arg Gly Arg Leu Cys Leu Trp Glu Lys Gly Gln Lys Ser
         275                 280                 285

 cca cct ttc cac ccc tgt ccg cgg ctt gca gtt ctg gtt att tcc tgg      912
 Pro Pro Phe His Pro Cys Pro Arg Leu Ala Val Leu Val Ile Ser Trp
     290                 295                 300

 gcg ccg ggc ccc gtg gct cag gcc tgt cat ccc agc act ttg gga ggc      960
 Ala Pro Gly Pro Val Ala Gln Ala Cys His Pro Ser Thr Leu Gly Gly
 305                 310                 315                 320

 tga                                                                  963
 






      <210> 709
      <211> 1449
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (1)..(1449)

      <400> 709
  atg aac agg ttt aag tct cag ttc tgc cag tta ctt gct tgc agc ttt      48
  Met Asn Arg Phe Lys Ser Gln Phe Cys Gln Leu Leu Ala Cys Ser Phe
    1               5                  10                  15

 ggg cag ctc agg tac aag gaa ata tcc aca gtg gga aga tta ggg agc       96
 Gly Gln Leu Arg Tyr Lys Glu Ile Ser Thr Val Gly Arg Leu Gly Ser
              20                  25                  30

 cat cct ggt ata gaa gcc tcg tgc atc aaa aat gtc aat gtg tgt tgt      144
 His Pro Gly Ile Glu Ala Ser Cys Ile Lys Asn Val Asn Val Cys Cys
          35                  40                  45

 aaa act acc ttc aga gga gcc caa agc tat agc ttc cca cca ggt cga      192
 Lys Thr Thr Phe Arg Gly Ala Gln Ser Tyr Ser Phe Pro Pro Gly Arg
      50                  55                  60

 atc aaa tat tcg gaa cag gtg tat gat gcc tgt atg gag aca ttt gac      240
 Ile Lys Tyr Ser Glu Gln Val Tyr Asp Ala Cys Met Glu Thr Phe Asp
  65                  70                  75                  80

 tgt ctt cct ctt gct gcc ctc tta aac cag cag ttt ctc tgt gta cat      288
 Cys Leu Pro Leu Ala Ala Leu Leu Asn Gln Gln Phe Leu Cys Val His
                  85                  90                  95

 gga gga atg tca cct gaa att act tct tta gat gac att agg aaa tta      336
 Gly Gly Met Ser Pro Glu Ile Thr Ser Leu Asp Asp Ile Arg Lys Leu
             100                 105                 110

 gac agg ttt acg gaa cct ccc gcc ttt gga cct gtg tgt gac ctg ctt      384
 Asp Arg Phe Thr Glu Pro Pro Ala Phe Gly Pro Val Cys Asp Leu Leu
         115                 120                 125

 tgg tct gat ccc tca gag gat tat ggc aat gag aag acc ttg gag cac      432
 Trp Ser Asp Pro Ser Glu Asp Tyr Gly Asn Glu Lys Thr Leu Glu His
     130                 135                 140

 tat acc cac aac act gtc cga ggg tgc tct tat ttc tac agt tac cct      480
 Tyr Thr His Asn Thr Val Arg Gly Cys Ser Tyr Phe Tyr Ser Tyr Pro
 145                 150                 155                 160

 gca gtt tgt gaa ttt ttg cag aac aat aat tta cta tca att atc aga      528
 Ala Val Cys Glu Phe Leu Gln Asn Asn Asn Leu Leu Ser Ile Ile Arg
                 165                 170                 175

 gcc cat gaa gcc caa gat gct ggg tat cga atg tac agg aag agc caa      576
 Ala His Glu Ala Gln Asp Ala Gly Tyr Arg Met Tyr Arg Lys Ser Gln
             180                 185                 190

 gcc aca ggc ttt cca tca ctt att aca att ttc tct gcc ccc aat tac      624
 Ala Thr Gly Phe Pro Ser Leu Ile Thr Ile Phe Ser Ala Pro Asn Tyr
         195                 200                 205

 cta gat gtc tat aac aat aaa gct gct gtg ttg aaa tat gaa aac aat      672
 Leu Asp Val Tyr Asn Asn Lys Ala Ala Val Leu Lys Tyr Glu Asn Asn
     210                 215                 220

 gtc atg aat atc agg cag ttt aac tgt tct cca cac ccc tac tgg ctt      720
 Val Met Asn Ile Arg Gln Phe Asn Cys Ser Pro His Pro Tyr Trp Leu
 225                 230                 235                 240

 cca aac ttt atg gat gtt ttc aca tgg tct ttg cct ttt gtt ggg gaa      768
 Pro Asn Phe Met Asp Val Phe Thr Trp Ser Leu Pro Phe Val Gly Glu
                 245                 250                 255

 aaa gag atg ctg gta aat gtg ctc aac ata tgc tct gat gac gaa ctg      816
 Lys Glu Met Leu Val Asn Val Leu Asn Ile Cys Ser Asp Asp Glu Leu
             260                 265                 270

 att tct gat gat gaa gca gaa gga agc act aca gtt cgt aag gag atc      864
 Ile Ser Asp Asp Glu Ala Glu Gly Ser Thr Thr Val Arg Lys Glu Ile
         275                 280                 285

 atc agg aat aag atc aga gcc att ggg aag atg gca cgg gtc ttt tca      912
 Ile Arg Asn Lys Ile Arg Ala Ile Gly Lys Met Ala Arg Val Phe Ser
     290                 295                 300

 att ctt cgg caa gaa agt gag agt gtg ctg act ctc aag ggc ctg act      960
 Ile Leu Arg Gln Glu Ser Glu Ser Val Leu Thr Leu Lys Gly Leu Thr
 305                 310                 315                 320

 ccc aca ggc aca ctc cct ctg ggc gtc ctc tca gga ggc aag cag act     1008
 Pro Thr Gly Thr Leu Pro Leu Gly Val Leu Ser Gly Gly Lys Gln Thr
                 325                 330                 335

 atc gag aca gcc atc aga ggg ttc tcg ctt cag cac aag atc cgg agt     1056
 Ile Glu Thr Ala Ile Arg Gly Phe Ser Leu Gln His Lys Ile Arg Ser
             340                 345                 350

 ttt gaa gaa gcg cga ggt ctg gac cga att aat gag cga atg cca ccc     1104
 Phe Glu Glu Ala Arg Gly Leu Asp Arg Ile Asn Glu Arg Met Pro Pro
         355                 360                 365

 cga aag gat agc ata cac gct gat gag cca cgt cat gcc att gtc agc     1152
 Arg Lys Asp Ser Ile His Ala Asp Glu Pro Arg His Ala Ile Val Ser
     370                 375                 380

 ata gga ggc cct ttg aag ccc caa aat ggg tca ttt gca ctc cct tct     1200
 Ile Gly Gly Pro Leu Lys Pro Gln Asn Gly Ser Phe Ala Leu Pro Ser
 385                 390                 395                 400

 tct gcc tgc tcc tgt tcc cat gag tgg ttg gca tgg aaa ggg cca tca     1248
 Ser Ala Cys Ser Cys Ser His Glu Trp Leu Ala Trp Lys Gly Pro Ser
                 405                 410                 415

 gta gaa ctt ggc tgg caa cat ttg cag gag cag gaa tca aca gag gac     1296
 Val Glu Leu Gly Trp Gln His Leu Gln Glu Gln Glu Ser Thr Glu Asp
             420                 425                 430

 cca gga gaa agg gat gga gcc cag ggc atg aaa cat agt cca gat tcc     1344
 Pro Gly Glu Arg Asp Gly Ala Gln Gly Met Lys His Ser Pro Asp Ser
         435                 440                 445

 tgc tgg tat gtc cat gtg act tgg ttt caa ttc ctc acc att gtg tca     1392
 Cys Trp Tyr Val His Val Thr Trp Phe Gln Phe Leu Thr Ile Val Ser
     450                 455                 460

 ctg tgg cct tct aga gaa gtc caa act gct gga aac ggg cag tgc ttt     1440
 Leu Trp Pro Ser Arg Glu Val Gln Thr Ala Gly Asn Gly Gln Cys Phe
 465                 470                 475                 480

 ctg cgc taa                                                         1449
 Leu Arg 






      <210> 710
      <211> 471
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (1)..(471)

      <400> 710
  atg gca gat gcg ttt gct aac gtg gtg atg ctg ctg gtt gcc gct ggg      48
  Met Ala Asp Ala Phe Ala Asn Val Val Met Leu Leu Val Ala Ala Gly
    1               5                  10                  15

 gta ttc gct cag ggg ctt agc acc atc ggc ttt att caa agt ctg att       96
 Val Phe Ala Gln Gly Leu Ser Thr Ile Gly Phe Ile Gln Ser Leu Ile
              20                  25                  30

 tct atc gct acc tcg ttt ggt tcg gcg agt atc atc ctg atg ctg gta      144
 Ser Ile Ala Thr Ser Phe Gly Ser Ala Ser Ile Ile Leu Met Leu Val
          35                  40                  45

 ttg gtg att ctg aca atg ctg gcg gca gtc acg acc ggt tca ggc aat      192
 Leu Val Ile Leu Thr Met Leu Ala Ala Val Thr Thr Gly Ser Gly Asn
      50                  55                  60

 gcg ccg ttt tat gcg ttt gtt gag atg atc ccg aaa ctg gcg cac tct      240
 Ala Pro Phe Tyr Ala Phe Val Glu Met Ile Pro Lys Leu Ala His Ser
  65                  70                  75                  80

 tcc ggc att aac ccg gcg tat ttg act atc ccg atg ctg cag gcg tca      288
 Ser Gly Ile Asn Pro Ala Tyr Leu Thr Ile Pro Met Leu Gln Ala Ser
                  85                  90                  95

 aac ctt ggc cgt acc ctt tcg ccc gtt tct ggc gta gtc gtt gcg gtt      336
 Asn Leu Gly Arg Thr Leu Ser Pro Val Ser Gly Val Val Val Ala Val
             100                 105                 110

 gcc ggg atg gcg aag atc tcg ccg ttt gaa gtc gta aaa cgc acc tcg      384
 Ala Gly Met Ala Lys Ile Ser Pro Phe Glu Val Val Lys Arg Thr Ser
         115                 120                 125

 gta ccg gtg ctt gtt ggt ttg gtg att gtt atc gtt gct aca gag ctg      432
 Val Pro Val Leu Val Gly Leu Val Ile Val Ile Val Ala Thr Glu Leu
     130                 135                 140

 atg gtg cca gga acg gca gca gcg gtc aca ggc aag taa                  471
 Met Val Pro Gly Thr Ala Ala Ala Val Thr Gly Lys 
 145                 150                 155





      <210> 711
      <211> 693
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (1)..(693)

      <400> 711
  atg ctg ggc ctg agg cca gga ggg gct ggg ggc agc acg ctg gtc cca      48
  Met Leu Gly Leu Arg Pro Gly Gly Ala Gly Gly Ser Thr Leu Val Pro
    1               5                  10                  15

 gct gtg ttt gct tta tta gat cct ttg ggc ccg agc ctg cag agc cga       96
 Ala Val Phe Ala Leu Leu Asp Pro Leu Gly Pro Ser Leu Gln Ser Arg
              20                  25                  30

 aag gcc gcc gtc act gtc gtg ggg ggt tgg cag tcc att cag ccc caa      144
 Lys Ala Ala Val Thr Val Val Gly Gly Trp Gln Ser Ile Gln Pro Gln
          35                  40                  45

 acg acc ctc acc agg gcc cct cag ccc cac ccg gcc gat gga ttt tat      192
 Thr Thr Leu Thr Arg Ala Pro Gln Pro His Pro Ala Asp Gly Phe Tyr
      50                  55                  60

 tgt ctt aca ttt tca ttc ctc ggc cac act ctt tct agt caa ctc cac      240
 Cys Leu Thr Phe Ser Phe Leu Gly His Thr Leu Ser Ser Gln Leu His
  65                  70                  75                  80

 cag ctg gag cag atg cta ctg aac acc agc ttc cca ggc tac aac ctg      288
 Gln Leu Glu Gln Met Leu Leu Asn Thr Ser Phe Pro Gly Tyr Asn Leu
                  85                  90                  95

 acc ttg cag aca ccc acc atc cag tct ttg gcc ttc aag ctg agc tgt      336
 Thr Leu Gln Thr Pro Thr Ile Gln Ser Leu Ala Phe Lys Leu Ser Cys
             100                 105                 110

 gac ttc tct ggc ctc tcg ctg acc agt gcc act ctg aag cgg gtg ccc      384
 Asp Phe Ser Gly Leu Ser Leu Thr Ser Ala Thr Leu Lys Arg Val Pro
         115                 120                 125

 cag agc gat ggt tat cgc ata ctg gtc gac cgc ctc tgg ccg cgc ggt      432
 Gln Ser Asp Gly Tyr Arg Ile Leu Val Asp Arg Leu Trp Pro Arg Gly
     130                 135                 140

 atc aaa aaa acc gat tta gcc ctt gat gag tgg gat aaa gaa atc acg      480
 Ile Lys Lys Thr Asp Leu Ala Leu Asp Glu Trp Asp Lys Glu Ile Thr
 145                 150                 155                 160

 ccg tca acg gaa ctg cgc aaa gcc ttt cac ggc gaa gtc gtc gat tat      528
 Pro Ser Thr Glu Leu Arg Lys Ala Phe His Gly Glu Val Val Asp Tyr
                 165                 170                 175

 gca acc ttt cgc gag caa tat ctt gca gaa ctg gcg caa cac gag caa      576
 Ala Thr Phe Arg Glu Gln Tyr Leu Ala Glu Leu Ala Gln His Glu Gln
             180                 185                 190

 gaa gga aag cgg ctg gcg gac atc gcc aaa aaa cag ccg ctg acc ttg      624
 Glu Gly Lys Arg Leu Ala Asp Ile Ala Lys Lys Gln Pro Leu Thr Leu
         195                 200                 205

 ctc tac tca gca aaa aac acc acg cag aac cat gcg ctg gtg ctg gcc      672
 Leu Tyr Ser Ala Lys Asn Thr Thr Gln Asn His Ala Leu Val Leu Ala
     210                 215                 220

 gac tgg cta cgt agc ttg tga                                          693
 Asp Trp Leu Arg Ser Leu 
 225                 230





      <210> 712
      <211> 807
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (1)..(807)

      <220>
      <221> misc_feature
      <222> (1)...(807)
      <223> n = a,t,c or g

      <400> 712
  atg agg ttt ccc tct tct ggg gcc cca ctt ttt gga ctg ctg tat gat      48
  Met Arg Phe Pro Ser Ser Gly Ala Pro Leu Phe Gly Leu Leu Tyr Asp
    1               5                  10                  15

 ctc tgg agg tct cgc ttc tct ggc gtg gtt aat cca cgc act atc agc       96
 Leu Trp Arg Ser Arg Phe Ser Gly Val Val Asn Pro Arg Thr Ile Ser
              20                  25                  30

 ggc agc aat acc gta ccg tct act cag gtg gcg gat gcg cgc att gaa      144
 Gly Ser Asn Thr Val Pro Ser Thr Gln Val Ala Asp Ala Arg Ile Glu
          35                  40                  45

 tac gta ggc aat ggc tac att aac gaa gcg caa aat atg ggc tgg ttg      192
 Tyr Val Gly Asn Gly Tyr Ile Asn Glu Ala Gln Asn Met Gly Trp Leu
      50                  55                  60

 cag cgt ttc ttc ctt aac ctg tcg cca atg agc ctc cgt tgc ggt aac      240
 Gln Arg Phe Phe Leu Asn Leu Ser Pro Met Ser Leu Arg Cys Gly Asn
  65                  70                  75                  80

 agt gtt cag gta aac caa ctg aac ggt gga cgg atc acc aat ggt gcg      288
 Ser Val Gln Val Asn Gln Leu Asn Gly Gly Arg Ile Thr Asn Gly Ala
                  85                  90                  95

 gtt att gaa cgt gaa ttg ccc agc cag ttt ggc gtc ggg aat acc ctt      336
 Val Ile Glu Arg Glu Leu Pro Ser Gln Phe Gly Val Gly Asn Thr Leu
             100                 105                 110

 aat ttg caa ctt aac gac gaa gat ttc agc atg gcg cag caa atc gct      384
 Asn Leu Gln Leu Asn Asp Glu Asp Phe Ser Met Ala Gln Gln Ile Ala
         115                 120                 125

 gac acc atc aac cgc gtg cgt gga tat ggc agc gcc acc gcg tta gat      432
 Asp Thr Ile Asn Arg Val Arg Gly Tyr Gly Ser Ala Thr Ala Leu Asp
     130                 135                 140

 gcg cgg act att cag gtg cgc gta ccg agt ggc aac agt tcc cag gtc      480
 Ala Arg Thr Ile Gln Val Arg Val Pro Ser Gly Asn Ser Ser Gln Val
 145                 150                 155                 160

 cgc ttc ctt gcc gat att cag aat atg cag gtt aat gtc acc ccg cag      528
 Arg Phe Leu Ala Asp Ile Gln Asn Met Gln Val Asn Val Thr Pro Gln
                 165                 170                 175

 nac gct ana gta gtg att aac tcg cgc acc ggt tcg gtg gtg atg aat      576
 XXX Ala XXX Val Val Ile Asn Ser Arg Thr Gly Ser Val Val Met Asn
             180                 185                 190

 cgc gaa gtg acc ctc gac agc tgc gcg gta gcg cag ggg aat ctc tca      624
 Arg Glu Val Thr Leu Asp Ser Cys Ala Val Ala Gln Gly Asn Leu Ser
         195                 200                 205

 gta aca gtt aat cgt cag gcc aat gtc agc cag cca gat aca ccg ttt      672
 Val Thr Val Asn Arg Gln Ala Asn Val Ser Gln Pro Asp Thr Pro Phe
     210                 215                 220

 ggt ggt gga cag act gtg gta ctc aca aac gca gat cat tta cgc aga      720
 Gly Gly Gly Gln Thr Val Val Leu Thr Asn Ala Asp His Leu Arg Arg
 225                 230                 235                 240

 cgg cgg ttt ggt gca aag caa cca ttt gtt cgt gtt aac agc aac ata      768
 Arg Arg Phe Gly Ala Lys Gln Pro Phe Val Arg Val Asn Ser Asn Ile
                 245                 250                 255

 ggc tgc tac ggc aat tcc cag aat gtt aac gcc aat tag                  807
 Gly Cys Tyr Gly Asn Ser Gln Asn Val Asn Ala Asn 
             260                 265





      <210> 713
      <211> 645
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (615)..(645)

      <220>
      <221> misc_feature
      <222> (1)...(645)
      <223> n = a,t,c or g

      <400> 713
 atgcccgccg caaggacggg cattgcaggg gccagattac tgctgatgtt taaggataaa     60

 ttgacctttn cggcgcaaca ggatggtttt cgtgatacgc gcgccaatgg tacggccaac    120

 atacgggctg actttgtggc gatattccag atcgtcattg gtaagaacat agctgctatt    180

 cggctgaatg aagacgaagt cggcatcttt tcctggggcg atacggcctt tttgctgcag    240

 accgaaaata tctgctgcag taccgatttc ttcgaactga tcggtatcca gtacaaagta    300

 atgcgggcag gattcacaag taacgtcctg accttcctga cgtgcacgag tcacttcctc    360

 aacaccttcc gggctgctga cgtggcaaac gtgcagacgg caaccagcaa ctttcgccag    420

 atacagtacg cggcgaattg cttcacttcg atcagcgcgt tttcgcagtg caccagcacc    480

 gggctgaccc agttcgccca gcttctgcgc acctttgaag aactgccagt cgtttacatc    540

 actgaagtcg gtggcgatac cgcgaatcgc acaggtcgcc acgaaacatg tgaagccgac    600

 aacgcccaac ttca        tct act tga tgc aga cng cgc gat gct gta a     650
                  Met Lys Leu Gly Val Val Gly Phe Thr Cys Phe Val
                    1               5                  10





      <210> 714
      <211> 1722
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (1)..(1722)

      <400> 714
  atg ttt gtc gtg tgg cga cgc cag aac cca ggc ata agt tgg ctg ctt      48
  Met Phe Val Val Trp Arg Arg Gln Asn Pro Gly Ile Ser Trp Leu Leu
    1               5                  10                  15

 gct gcc tgc agt cag cgc gac ttc gac gcc att cgc cct gtc ttc ttt       96
 Ala Ala Cys Ser Gln Arg Asp Phe Asp Ala Ile Arg Pro Val Phe Phe
              20                  25                  30

 tct act tct cag ctt ggc cag gct gcg ccg tct ttt ggc gga acc act      144
 Ser Thr Ser Gln Leu Gly Gln Ala Ala Pro Ser Phe Gly Gly Thr Thr
          35                  40                  45

 ggc aca ctt cag gat gcc ttt gat ctg gag gcg cta aag gcc ctc gat      192
 Gly Thr Leu Gln Asp Ala Phe Asp Leu Glu Ala Leu Lys Ala Leu Asp
      50                  55                  60

 atc att gtg acc tgt cag ggc ggc gat tat acc aac gaa atc tat cca      240
 Ile Ile Val Thr Cys Gln Gly Gly Asp Tyr Thr Asn Glu Ile Tyr Pro
  65                  70                  75                  80

 aag ctt cgt gaa agc gga tgg caa ggt tac tgg att gac gca gca tcg      288
 Lys Leu Arg Glu Ser Gly Trp Gln Gly Tyr Trp Ile Asp Ala Ala Ser
                  85                  90                  95

 tct ctg cgc atg aaa gat gac gcc atc atc att ctt gac ccc gtc aat      336
 Ser Leu Arg Met Lys Asp Asp Ala Ile Ile Ile Leu Asp Pro Val Asn
             100                 105                 110

 cag gac gtc att acc gac gga tta aat aat ggc atc agg act ttt gtt      384
 Gln Asp Val Ile Thr Asp Gly Leu Asn Asn Gly Ile Arg Thr Phe Val
         115                 120                 125

 ggc ggt aac tgt acc gta agc ctg atg ttg atg tcg ttg ggt ggt tta      432
 Gly Gly Asn Cys Thr Val Ser Leu Met Leu Met Ser Leu Gly Gly Leu
     130                 135                 140

 ttc gcc aat gat ctt gtt gat tgg gtg tcc gtt gca acc tac cag gcc      480
 Phe Ala Asn Asp Leu Val Asp Trp Val Ser Val Ala Thr Tyr Gln Ala
 145                 150                 155                 160

 gct tgc ggc ggt ggt gcg cga cat atg cgt gag tta tta acc cag atg      528
 Ala Cys Gly Gly Gly Ala Arg His Met Arg Glu Leu Leu Thr Gln Met
                 165                 170                 175

 ggc cat ctg tat ggc cat gtg gca gat gaa ctc gcg acc ccg tcc tct      576
 Gly His Leu Tyr Gly His Val Ala Asp Glu Leu Ala Thr Pro Ser Ser
             180                 185                 190

 gct att ctc gat atc gaa cgc aaa gtc aca acc tta acc cgt agc ggt      624
 Ala Ile Leu Asp Ile Glu Arg Lys Val Thr Thr Leu Thr Arg Ser Gly
         195                 200                 205

 gag ctg ccg gtg gat aac ttt ggc gtg cca ctg gcg ggt agc ctg att      672
 Glu Leu Pro Val Asp Asn Phe Gly Val Pro Leu Ala Gly Ser Leu Ile
     210                 215                 220

 ccg tgg atc gac aaa cag ctc gat aac tgt cac agc cgc gaa gag tgg      720
 Pro Trp Ile Asp Lys Gln Leu Asp Asn Cys His Ser Arg Glu Glu Trp
 225                 230                 235                 240

 aaa ggg cag gcg gaa acc aac aag atc ctc aac aca tct tcc gta att      768
 Lys Gly Gln Ala Glu Thr Asn Lys Ile Leu Asn Thr Ser Ser Val Ile
                 245                 250                 255

 ccg gta gat ggt tta tgt gtg cgt gtc ggg gca ttg cgc tgc cac agc      816
 Pro Val Asp Gly Leu Cys Val Arg Val Gly Ala Leu Arg Cys His Ser
             260                 265                 270

 cag gca ttc act att aaa ttg aaa aaa gat gtg tct att ccg acc gtg      864
 Gln Ala Phe Thr Ile Lys Leu Lys Lys Asp Val Ser Ile Pro Thr Val
         275                 280                 285

 gaa gaa ctg ctg gct gcg cac aat ccg tgg gcg aaa gtc gtt ccg aac      912
 Glu Glu Leu Leu Ala Ala His Asn Pro Trp Ala Lys Val Val Pro Asn
     290                 295                 300

 gat cgg gaa ata cta tgc gct gct tct gac gtt cgt gat gag ttt gta      960
 Asp Arg Glu Ile Leu Cys Ala Ala Ser Asp Val Arg Asp Glu Phe Val
 305                 310                 315                 320

 tct gtt act gag aag tta atg gat gaa ttg gca caa tgc tac aat gtg     1008
 Ser Val Thr Glu Lys Leu Met Asp Glu Leu Ala Gln Cys Tyr Asn Val
                 325                 330                 335

 ctc ccc caa ctt gat att aat aac act ata gac cac cgc ccc gaa ggg     1056
 Leu Pro Gln Leu Asp Ile Asn Asn Thr Ile Asp His Arg Pro Glu Gly
             340                 345                 350

 gac gaa aaa tgg ttt tta gag aac gag aag acg gtt acg cag ttt tgc     1104
 Asp Glu Lys Trp Phe Leu Glu Asn Glu Lys Thr Val Thr Gln Phe Cys
         355                 360                 365

 cgc aag ctg gct gct gaa cgc cct ctt aag gat att cgc gat gag tat     1152
 Arg Lys Leu Ala Ala Glu Arg Pro Leu Lys Asp Ile Arg Asp Glu Tyr
     370                 375                 380

 aat tac ccc aaa aag aaa gtt tct ccc tat tac cgg aca aag ctg cgt     1200
 Asn Tyr Pro Lys Lys Lys Val Ser Pro Tyr Tyr Arg Thr Lys Leu Arg
 385                 390                 395                 400

 ggc ctc tac aca acc gcc aag gcc gat gca gag gct gag tgc aac atc     1248
 Gly Leu Tyr Thr Thr Ala Lys Ala Asp Ala Glu Ala Glu Cys Asn Ile
                 405                 410                 415

 ctt cgg aaa gct ctg gac aag atc gcg gaa atc aag tct ctg ttg gaa     1296
 Leu Arg Lys Ala Leu Asp Lys Ile Ala Glu Ile Lys Ser Leu Leu Glu
             420                 425                 430

 gag agg cgg att gct act caa gaa gcc gaa gtg gaa aaa cca ccc aaa     1344
 Glu Arg Arg Ile Ala Thr Gln Glu Ala Glu Val Glu Lys Pro Pro Lys
         435                 440                 445

 ccc aag aag tgg agg gtg gat gaa gtg gaa caa tcg ccc aag ccc aag     1392
 Pro Lys Lys Trp Arg Val Asp Glu Val Glu Gln Ser Pro Lys Pro Lys
     450                 455                 460

 agg cag agg gag gcc gag gca caa caa tta ccc aaa ccc aag agg cgg     1440
 Arg Gln Arg Glu Ala Glu Ala Gln Gln Leu Pro Lys Pro Lys Arg Arg
 465                 470                 475                 480

 agg ttg aca acc agc gcc ccc cag cag ccc cca ggc ccg gag gac gag     1488
 Arg Leu Thr Thr Ser Ala Pro Gln Gln Pro Pro Gly Pro Glu Asp Glu
                 485                 490                 495

 gac tcc agc ctg gat gaa tct gac ctc tat agc ctg gcc cat tcc tac     1536
 Asp Ser Ser Leu Asp Glu Ser Asp Leu Tyr Ser Leu Ala His Ser Tyr
             500                 505                 510

 ctc ggg cct ctc atc atg cct atg ccc act tca cct ctg act cct gcc     1584
 Leu Gly Pro Leu Ile Met Pro Met Pro Thr Ser Pro Leu Thr Pro Ala
         515                 520                 525

 ttg gtt aca gga ggt gga ggc cgg aaa ggt cgc acc aag aga gaa gct     1632
 Leu Val Thr Gly Gly Gly Gly Arg Lys Gly Arg Thr Lys Arg Glu Ala
     530                 535                 540

 gct gcc aac acc aac cgc ccc agc cct ggc ggg cac gag agg aaa ctg     1680
 Ala Ala Asn Thr Asn Arg Pro Ser Pro Gly Gly His Glu Arg Lys Leu
 545                 550                 555                 560

 gtg acc aag ctg cag ctt gca tgc tcc ctt cgg tcc att tga             1722
 Val Thr Lys Leu Gln Leu Ala Cys Ser Leu Arg Ser Ile 
                 565                 570





      <210> 715
      <211> 534
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (1)..(534)

      <400> 715
  atg tcc ctg aga agt ctg agc ttc aca ata cca ttg tac ctt ggt ttt      48
  Met Ser Leu Arg Ser Leu Ser Phe Thr Ile Pro Leu Tyr Leu Gly Phe
    1               5                  10                  15

 gga tac gac ttt gag ctc ggt acc cca ctg cat ccg ggg caa tcc gca       96
 Gly Tyr Asp Phe Glu Leu Gly Thr Pro Leu His Pro Gly Gln Ser Ala
              20                  25                  30

 gcg att tat ctg aaa ggt gaa cgt att ggt ttt gtt ggg gtt gtt cat      144
 Ala Ile Tyr Leu Lys Gly Glu Arg Ile Gly Phe Val Gly Val Val His
          35                  40                  45

 cct gaa ctg gaa cgt aaa ctg gat ctt aac ggt cgc act ctg gtg ttc      192
 Pro Glu Leu Glu Arg Lys Leu Asp Leu Asn Gly Arg Thr Leu Val Phe
      50                  55                  60

 gaa ctg gag tgg aac aag ctc gca tac cgc gtg gtg cct cag gcg cgc      240
 Glu Leu Glu Trp Asn Lys Leu Ala Tyr Arg Val Val Pro Gln Ala Arg
  65                  70                  75                  80

 gag att tct cgc ttc ccg gcg aac cgt cgt gac atc gcg gtg gtg gtc      288
 Glu Ile Ser Arg Phe Pro Ala Asn Arg Arg Asp Ile Ala Val Val Val
                  85                  90                  95

 gca gaa aac gtt ccc gca gcg gat att tta tcc gaa tgt aag aaa gtt      336
 Ala Glu Asn Val Pro Ala Ala Asp Ile Leu Ser Glu Cys Lys Lys Val
             100                 105                 110

 ggc gta aat caa gta gtt ggc gta aac tta ttt gac atg tac cgc ggt      384
 Gly Val Asn Gln Val Val Gly Val Asn Leu Phe Asp Met Tyr Arg Gly
         115                 120                 125

 aag ggt gtt gcg gag ggg tat aag agc ctc gcc ata agc ctg atc ctg      432
 Lys Gly Val Ala Glu Gly Tyr Lys Ser Leu Ala Ile Ser Leu Ile Leu
     130                 135                 140

 caa gat acc agc cgt aca ctc gaa gaa gag gag att gcc gct acc gtc      480
 Gln Asp Thr Ser Arg Thr Leu Glu Glu Glu Glu Ile Ala Ala Thr Val
 145                 150                 155                 160

 gcc aaa tgt gta gag gca tta aaa gag cga tcc cag gca tca ttg agg      528
 Ala Lys Cys Val Glu Ala Leu Lys Glu Arg Ser Gln Ala Ser Leu Arg
                 165                 170                 175

 aat tga                                                              534
 Asn 






      <210> 716
      <211> 507
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (1)..(507)

      <400> 716
  atg atc ttg gcc ctg att gca ttc atc tgc ata gag acc atc atg gca      48
  Met Ile Leu Ala Leu Ile Ala Phe Ile Cys Ile Glu Thr Ile Met Ala
    1               5                  10                  15

 tgc tcc ccg tgt gaa ggc ctc tac ttt ttt gag ttt gtg agc tgc agt       96
 Cys Ser Pro Cys Glu Gly Leu Tyr Phe Phe Glu Phe Val Ser Cys Ser
              20                  25                  30

 gcg ttt gtg gtg act ggc gtc ttg ctg att atg ttc agt ctc aac ctg      144
 Ala Phe Val Val Thr Gly Val Leu Leu Ile Met Phe Ser Leu Asn Leu
          35                  40                  45

 cac atg agg atc ccc cag atc aac tgg aat ctg aca ggt caa ggt caa      192
 His Met Arg Ile Pro Gln Ile Asn Trp Asn Leu Thr Gly Gln Gly Gln
      50                  55                  60

 ggt cag cat ctt gtt cat tgc tat cct act tgc cta gtg ttc ctg agg      240
 Gly Gln His Leu Val His Cys Tyr Pro Thr Cys Leu Val Phe Leu Arg
  65                  70                  75                  80

 cct gtc aat aaa tac ttg ttg agt aag ggg ctg ggc tgt gaa acc ctg      288
 Pro Val Asn Lys Tyr Leu Leu Ser Lys Gly Leu Gly Cys Glu Thr Leu
                  85                  90                  95

 cgg gag gac ctg ttt gac aaa gaa gca gct gct gga aag gtt aag act      336
 Arg Glu Asp Leu Phe Asp Lys Glu Ala Ala Ala Gly Lys Val Lys Thr
             100                 105                 110

 ata ggc att gag tca gac aga ccg agc tgg gtt caa gtc caa gac ggt      384
 Ile Gly Ile Glu Ser Asp Arg Pro Ser Trp Val Gln Val Gln Asp Gly
         115                 120                 125

 aac aat cag cca ctt gct ctg ctg aat att cat ctt ccg gtc atg atg      432
 Asn Asn Gln Pro Leu Ala Leu Leu Asn Ile His Leu Pro Val Met Met
     130                 135                 140

 tta cgc ata gcg cat ggg ccg atg gat acc agg tat ccg cct gaa ata      480
 Leu Arg Ile Ala His Gly Pro Met Asp Thr Arg Tyr Pro Pro Glu Ile
 145                 150                 155                 160

 aac ggc cta tcg aag aaa acc gct taa                                  507
 Asn Gly Leu Ser Lys Lys Thr Ala 
                 165





      <210> 717
      <211> 1062
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (1)..(1062)

      <220>
      <221> misc_feature
      <222> (1)...(1062)
      <223> n = a,t,c or g

      <400> 717
  atg att att ttc ccg ctg ctg aat gat ttg cgc gtc ttt atg ctg gtg      48
  Met Ile Ile Phe Pro Leu Leu Asn Asp Leu Arg Val Phe Met Leu Val
    1               5                  10                  15

 gct ccc cgg gct ggt ttt ccc ccc gtg ccg gaa gaa ctg ggc gtt tca       96
 Ala Pro Arg Ala Gly Phe Pro Pro Val Pro Glu Glu Leu Gly Val Ser
              20                  25                  30

 ccg gcg ttc gtc agc aag cgc atc gcc ttg ctg gag caa acg cta aac      144
 Pro Ala Phe Val Ser Lys Arg Ile Ala Leu Leu Glu Gln Thr Leu Asn
          35                  40                  45

 gtg gtg ttg tta cac cgc acc acc cgc cgc gtc acc att acc gaa gaa      192
 Val Val Leu Leu His Arg Thr Thr Arg Arg Val Thr Ile Thr Glu Glu
      50                  55                  60

 gga gag cgg att tat gaa tgg gcg cag cgg att ttg cag gat gtc ggt      240
 Gly Glu Arg Ile Tyr Glu Trp Ala Gln Arg Ile Leu Gln Asp Val Gly
  65                  70                  75                  80

 cag atg atg gac gaa ctt tct gac gtg cgt cag gtg ccg cag ggg atg      288
 Gln Met Met Asp Glu Leu Ser Asp Val Arg Gln Val Pro Gln Gly Met
                  85                  90                  95

 ctg cgt att atc agc agc ttt ggt ttt gga cga cag gtg gtg gct ccg      336
 Leu Arg Ile Ile Ser Ser Phe Gly Phe Gly Arg Gln Val Val Ala Pro
             100                 105                 110

 gcg tta tta gcg ctg gcg aag gcg tat ccg caa ctg gaa tta cgt ttt      384
 Ala Leu Leu Ala Leu Ala Lys Ala Tyr Pro Gln Leu Glu Leu Arg Phe
         115                 120                 125

 gat gtg gaa gac cga ctg gtc gat ttg gtc aat gaa ggt gtc gat ctc      432
 Asp Val Glu Asp Arg Leu Val Asp Leu Val Asn Glu Gly Val Asp Leu
     130                 135                 140

 gat att cgc att ggc gat gac atc gcc cct aat tta atc gcc cgc aaa      480
 Asp Ile Arg Ile Gly Asp Asp Ile Ala Pro Asn Leu Ile Ala Arg Lys
 145                 150                 155                 160

 ctg gcg acc aat tac cgt att ctc tgc gcg tcg ccg gaa ttt att gcg      528
 Leu Ala Thr Asn Tyr Arg Ile Leu Cys Ala Ser Pro Glu Phe Ile Ala
                 165                 170                 175

 caa cat ggc gcg ccg aaa cat tta acc gat ctt tct gca ttg ccg tgc      576
 Gln His Gly Ala Pro Lys His Leu Thr Asp Leu Ser Ala Leu Pro Cys
             180                 185                 190

 ctg gtc att aaa gag cgc gat cat cct ttt ggt gtc tgg cnn ttn cgc      624
 Leu Val Ile Lys Glu Arg Asp His Pro Phe Gly Val Trp XXX XXX Arg
         195                 200                 205

 cat acg gga ggc ccc cnt gga cgg aaa aaa att gct aac cct ttt gcc      672
 His Thr Gly Gly Pro XXX Gly Arg Lys Lys Ile Ala Asn Pro Phe Ala
     210                 215                 220

 acg aat tgg gcc cgg gcc aat atg gct cat ttt ctc ggc aaa ggc gat      720
 Thr Asn Trp Ala Arg Ala Asn Met Ala His Phe Leu Gly Lys Gly Asp
 225                 230                 235                 240

 aag cgt ttc cag caa gcg caa aac ggt att ctg gca gcc att gaa gaa      768
 Lys Arg Phe Gln Gln Ala Gln Asn Gly Ile Leu Ala Ala Ile Glu Glu
                 245                 250                 255

 gat gat aag gac tta gaa ttg acc ata gat tgt cat ggt gaa gag atg      816
 Asp Asp Lys Asp Leu Glu Leu Thr Ile Asp Cys His Gly Glu Glu Met
             260                 265                 270

 att ggt gac ctt gat aag aac agt ttt ggc gct gtt ggt ttg tgc atc      864
 Ile Gly Asp Leu Asp Lys Asn Ser Phe Gly Ala Val Gly Leu Cys Ile
         275                 280                 285

 gga gag aga gta gga ggg cct ggg tgc tgt gaa gtc cta att aga atg      912
 Gly Glu Arg Val Gly Gly Pro Gly Cys Cys Glu Val Leu Ile Arg Met
     290                 295                 300

 act cca aca gag gat gtg gga gaa gag agg tct gac atg gta cta tat      960
 Thr Pro Thr Glu Asp Val Gly Glu Glu Arg Ser Asp Met Val Leu Tyr
 305                 310                 315                 320

 gct ggg aaa atg ggg atg act cta gag gat ccc cgg ggn cca tnc gat     1008
 Ala Gly Lys Met Gly Met Thr Leu Glu Asp Pro Arg XXX Pro XXX Asp
                 325                 330                 335

 gac tat cgt gat cgc cat cgg tac cga aga aaa ccc ccc gtt ttc aag     1056
 Asp Tyr Arg Asp Arg His Arg Tyr Arg Arg Lys Pro Pro Val Phe Lys
             340                 345                 350

 cac tga                                                             1062
 His 






      <210> 718
      <211> 327
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (1)..(327)

      <220>
      <221> misc_feature
      <222> (1)...(327)
      <223> n = a,t,c or g

      <400> 718
  atg gtg gtc ggc gtg ggg tat tca atc ctc aac cag tta cca cag ttt      48
  Met Val Val Gly Val Gly Tyr Ser Ile Leu Asn Gln Leu Pro Gln Phe
    1               5                  10                  15

 aat atg ccc cag tat ttc gca cat ggt gca gtg cta agt att ttc gtc       96
 Asn Met Pro Gln Tyr Phe Ala His Gly Ala Val Leu Ser Ile Phe Val
              20                  25                  30

 ggt gcc att ctc tgg ctg gcg ggt gcc cgt gtt ggc ggg cat gaa cag      144
 Gly Ala Ile Leu Trp Leu Ala Gly Ala Arg Val Gly Gly His Glu Gln
          35                  40                  45

 gtg tgc gac cgt tac tgc gcg agc cat agt gcg cag tgg ctg gaa ttc      192
 Val Cys Asp Arg Tyr Cys Ala Ser His Ser Ala Gln Trp Leu Glu Phe
      50                  55                  60

 cac gtt gca cac gcg caa ttc aca tcc ctc ggg cag acg ctt cac aaa      240
 His Val Ala His Ala Gln Phe Thr Ser Leu Gly Gln Thr Leu His Lys
  65                  70                  75                  80

 acg ctt gaa cgc atc aag acc acc agc atc aag tac cgg aac ggc atc      288
 Thr Leu Glu Arg Ile Lys Thr Thr Ser Ile Lys Tyr Arg Asn Gly Ile
                  85                  90                  95

 cca ctt cag aat cac aat ncc gtt tgc ttc aaa acg tga                  327
 Pro Leu Gln Asn His Asn XXX Val Cys Phe Lys Thr 
             100                 105





      <210> 719
      <211> 384
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (1)..(384)

      <400> 719
  atg gaa ggt tca aga atg aaa tac cgc atc gct tta gct gtt tct ctc      48
  Met Glu Gly Ser Arg Met Lys Tyr Arg Ile Ala Leu Ala Val Ser Leu
    1               5                  10                  15

 ttt gct ctt agt gcc ggt agt tat gcc act acc ctg tgt cag gaa aag       96
 Phe Ala Leu Ser Ala Gly Ser Tyr Ala Thr Thr Leu Cys Gln Glu Lys
              20                  25                  30

 gag caa aat atc ctt aag gag atc agc tat gcc gaa aaa cac caa aac      144
 Glu Gln Asn Ile Leu Lys Glu Ile Ser Tyr Ala Glu Lys His Gln Asn
          35                  40                  45

 cag aat cgt att gac ggt ctg aat aaa gcc ctg agt gaa gtc cgg gcc      192
 Gln Asn Arg Ile Asp Gly Leu Asn Lys Ala Leu Ser Glu Val Arg Ala
      50                  55                  60

 aac tgt tca gat agc cag ctg cgt gcc gat cat cag aag aaa atc gca      240
 Asn Cys Ser Asp Ser Gln Leu Arg Ala Asp His Gln Lys Lys Ile Ala
  65                  70                  75                  80

 aag cag aaa gat gag gtg gcg gaa cgc cag caa gat tta gcc gag gcg      288
 Lys Gln Lys Asp Glu Val Ala Glu Arg Gln Gln Asp Leu Ala Glu Ala
                  85                  90                  95

 aag caa aaa ggc gat gcc gat aag att gcc aaa cgc gaa cgg aaa ctg      336
 Lys Gln Lys Gly Asp Ala Asp Lys Ile Ala Lys Arg Glu Arg Lys Leu
             100                 105                 110

 gca gaa gcg cag gaa gag ctg aaa aag ctg gaa gcg cgc gac tac taa      384
 Ala Glu Ala Gln Glu Glu Leu Lys Lys Leu Glu Ala Arg Asp Tyr 
         115                 120                 125





      <210> 720
      <211> 525
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (1)..(525)

      <400> 720
  atg ccg cgt tct ttg gaa cta ctt gtt atc gtg gtt acc ggt agc gtc      48
  Met Pro Arg Ser Leu Glu Leu Leu Val Ile Val Val Thr Gly Ser Val
    1               5                  10                  15

 acc tct cag gtg aaa aat gcc gac tat ctg att ctg gat ccc gta aat       96
 Thr Ser Gln Val Lys Asn Ala Asp Tyr Leu Ile Leu Asp Pro Val Asn
              20                  25                  30

 aat cag gtt tac gtc aat cca acc aac gaa gtt att gat aaa atg cgc      144
 Asn Gln Val Tyr Val Asn Pro Thr Asn Glu Val Ile Asp Lys Met Arg
          35                  40                  45

 gct gtt cag gag caa gtg gct tct gaa aaa gca gag ctt gct aaa ctg      192
 Ala Val Gln Glu Gln Val Ala Ser Glu Lys Ala Glu Leu Ala Lys Leu
      50                  55                  60

 aaa gat ctg cca gct att acg ctg gac ggt cac cag gta gaa gta tgc      240
 Lys Asp Leu Pro Ala Ile Thr Leu Asp Gly His Gln Val Glu Val Cys
  65                  70                  75                  80

 gct aac att ggt acg gtt cgt gac gtt gaa ggt gca gag cgt aac ggc      288
 Ala Asn Ile Gly Thr Val Arg Asp Val Glu Gly Ala Glu Arg Asn Gly
                  85                  90                  95

 gct gaa ggc gtt ggt ctg tat cgt act gag ttc ctg ttc atg gac cgc      336
 Ala Glu Gly Val Gly Leu Tyr Arg Thr Glu Phe Leu Phe Met Asp Arg
             100                 105                 110

 gac gca ctg ccc act gaa gaa gaa cag ttt gct gct tac aaa gca gtg      384
 Asp Ala Leu Pro Thr Glu Glu Glu Gln Phe Ala Ala Tyr Lys Ala Val
         115                 120                 125

 gct gaa gcg tgt ggc tcg caa gcg gtt atc gtt cgt acc atg gac atc      432
 Ala Glu Ala Cys Gly Ser Gln Ala Val Ile Val Arg Thr Met Asp Ile
     130                 135                 140

 ggc ggc gac aaa gag ctg cca tac atg aac ttc ccg aaa gaa gag aac      480
 Gly Gly Asp Lys Glu Leu Pro Tyr Met Asn Phe Pro Lys Glu Glu Asn
 145                 150                 155                 160

 ccg ttc ctc gag ctg gcg cgc tat ccg tat cgc gat gga tcg tag          525
 Pro Phe Leu Glu Leu Ala Arg Tyr Pro Tyr Arg Asp Gly Ser 
                 165                 170





      <210> 721
      <211> 1878
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (1)..(1878)

      <400> 721
  atg agc cat ctt att cac cgc ctg ttg ata ttg gcg gct atc tgg aat      48
  Met Ser His Leu Ile His Arg Leu Leu Ile Leu Ala Ala Ile Trp Asn
    1               5                  10                  15

 gac caa acg gtg gct gct gat aac cgc att gcc tgg ttc gaa gcg cgg       96
 Asp Gln Thr Val Ala Ala Asp Asn Arg Ile Ala Trp Phe Glu Ala Arg
              20                  25                  30

 act ata gca ggt tat cca gtg ctg gtg agc gag gaa aac ggc gta gtg      144
 Thr Ile Ala Gly Tyr Pro Val Leu Val Ser Glu Glu Asn Gly Val Val
          35                  40                  45

 acg gga tat gcc tcg tat ggc gaa tgg cgt aat acg atg cgc atc ggc      192
 Thr Gly Tyr Ala Ser Tyr Gly Glu Trp Arg Asn Thr Met Arg Ile Gly
      50                  55                  60

 aat gtc aat gtc gcc acg gga gag ctg cag gcg acg gga ggc act ttc      240
 Asn Val Asn Val Ala Thr Gly Glu Leu Gln Ala Thr Gly Gly Thr Phe
  65                  70                  75                  80

 acc aat aat ttt tac cga tac ccg ttt gaa gtt cgg ttt att gcc tgg      288
 Thr Asn Asn Phe Tyr Arg Tyr Pro Phe Glu Val Arg Phe Ile Ala Trp
                  85                  90                  95

 ata tca cgt aaa tct tcc cgc ata gac gtt gtt gta ggt ggt gct tca      336
 Ile Ser Arg Lys Ser Ser Arg Ile Asp Val Val Val Gly Gly Ala Ser
             100                 105                 110

 cgt gaa gat gca cag ttt att acc tgg gag cat ccg ctg atc cgc aac      384
 Arg Glu Asp Ala Gln Phe Ile Thr Trp Glu His Pro Leu Ile Arg Asn
         115                 120                 125

 ggt gtg acg gtt aac cgc gtt aag ctg gcg gtt aaa ggt ttc aaa ctc      432
 Gly Val Thr Val Asn Arg Val Lys Leu Ala Val Lys Gly Phe Lys Leu
     130                 135                 140

 tac ctg cgc cgc cag ata ctg tcc agc acc ggc gaa tta aga agc acc      480
 Tyr Leu Arg Arg Gln Ile Leu Ser Ser Thr Gly Glu Leu Arg Ser Thr
 145                 150                 155                 160

 agt atc acc ttc cag acc aac tac gcc ctg ata gcg ttc gcc ttc gct      528
 Ser Ile Thr Phe Gln Thr Asn Tyr Ala Leu Ile Ala Phe Ala Phe Ala
                 165                 170                 175

 cgg ggt aat ggt gat cac cac gta acc att gcc gat atg gaa ctg ctg      576
 Arg Gly Asn Gly Asp His His Val Thr Ile Ala Asp Met Glu Leu Leu
             180                 185                 190

 gac aac ggt aac ctg ggg cac gaa aaa cta acc cag gcg cga aac gag      624
 Asp Asn Gly Asn Leu Gly His Glu Lys Leu Thr Gln Ala Arg Asn Glu
         195                 200                 205

 ctg tta tca ctg gca gcg caa tca ccg aat cag gtc acc ggg gta cgc      672
 Leu Leu Ser Leu Ala Ala Gln Ser Pro Asn Gln Val Thr Gly Val Arg
     210                 215                 220

 ccg aac ggc ctg gaa gat acg ccg atg ttc aaa gtg aac gtc aac gct      720
 Pro Asn Gly Leu Glu Asp Thr Pro Met Phe Lys Val Asn Val Asn Ala
 225                 230                 235                 240

 gcg aaa gct gaa gcg atg ggc gtg gcg ctg tct gat atc aac cat att      768
 Ala Lys Ala Glu Ala Met Gly Val Ala Leu Ser Asp Ile Asn His Ile
                 245                 250                 255

 ttg att aat ccc ctt gcc gcc aac ggt gaa ggt aca tac ctg aat gta      816
 Leu Ile Asn Pro Leu Ala Ala Asn Gly Glu Gly Thr Tyr Leu Asn Val
             260                 265                 270

 ttt acc gtc cac ttt cac gca acc gac aag gtg ctg aaa gat gac aac      864
 Phe Thr Val His Phe His Ala Thr Asp Lys Val Leu Lys Asp Asp Asn
         275                 280                 285

 ctg ctg gcg ctg ttc gac atc ccg aaa atc ctc tgg cca ccc cca gca      912
 Leu Leu Ala Leu Phe Asp Ile Pro Lys Ile Leu Trp Pro Pro Pro Ala
     290                 295                 300

 caa tgc cga tac cct gca aaa aat gat gcc agt aga ctc agc cgg cag      960
 Gln Cys Arg Tyr Pro Ala Lys Asn Asp Ala Ser Arg Leu Ser Arg Gln
 305                 310                 315                 320

 tat tta tca tac agc gac cgt caa gcc cta ttt cgc gga tgc acg atc     1008
 Tyr Leu Ser Tyr Ser Asp Arg Gln Ala Leu Phe Arg Gly Cys Thr Ile
                 325                 330                 335

 tac cgc atc cac tca atc cac gtc cgg gct aat act cgc acc tgg tca     1056
 Tyr Arg Ile His Ser Ile His Val Arg Ala Asn Thr Arg Thr Trp Ser
             340                 345                 350

 gcg tgc gaa act cag cgg aaa cgc tgc gtg ctt aca cca ttt cct cca     1104
 Ala Cys Glu Thr Gln Arg Lys Arg Cys Val Leu Thr Pro Phe Pro Pro
         355                 360                 365

 cgc cag gca tac ata tcg tcg cga ata cca agt agc gtc ggc gca gaa     1152
 Arg Gln Ala Tyr Ile Ser Ser Arg Ile Pro Ser Ser Val Gly Ala Glu
     370                 375                 380

 gga gat cat att ggc ggt ttc acg cac ggt gta ctg cca cag cgt ccg     1200
 Gly Asp His Ile Gly Gly Phe Thr His Gly Val Leu Pro Gln Arg Pro
 385                 390                 395                 400

 gct tta gtg aac ctg caa tgc gat att gac cac ccg act cag tca atg     1248
 Ala Leu Val Asn Leu Gln Cys Asp Ile Asp His Pro Thr Gln Ser Met
                 405                 410                 415

 gct gac ctc gcg tgg tta cgt gaa cac ttt ggt tca ctg gaa aac ctg     1296
 Ala Asp Leu Ala Trp Leu Arg Glu His Phe Gly Ser Leu Glu Asn Leu
             420                 425                 430

 aaa ggt aaa aaa atc gcc atg acc tgg gcc tac tct cca agc tat ggc     1344
 Lys Gly Lys Lys Ile Ala Met Thr Trp Ala Tyr Ser Pro Ser Tyr Gly
         435                 440                 445

 aaa ccg ctc tct gta cca caa ggc atc atc ggt ctg atg act cgc ttc     1392
 Lys Pro Leu Ser Val Pro Gln Gly Ile Ile Gly Leu Met Thr Arg Phe
     450                 455                 460

 ggt atg gat gtc acc ctg gcc cat ccg gaa ggc tac gac ctg atc ccg     1440
 Gly Met Asp Val Thr Leu Ala His Pro Glu Gly Tyr Asp Leu Ile Pro
 465                 470                 475                 480

 gat gtg gtt gaa gtg gcg aaa aac aat gct aaa gcc tcc ggt ggt agc     1488
 Asp Val Val Glu Val Ala Lys Asn Asn Ala Lys Ala Ser Gly Gly Ser
                 485                 490                 495

 ttc cgt cag gtc acc agc atg gaa gaa gcc ttc aaa gac gca gac atc     1536
 Phe Arg Gln Val Thr Ser Met Glu Glu Ala Phe Lys Asp Ala Asp Ile
             500                 505                 510

 gtt tat ccg aag tca tgg gca cct tac aaa gtg atg gaa gag cgt act     1584
 Val Tyr Pro Lys Ser Trp Ala Pro Tyr Lys Val Met Glu Glu Arg Thr
         515                 520                 525

 gaa ttg ctg cgt gcg aac gat cac gaa ggc gta aaa cgc acc gga aaa     1632
 Glu Leu Leu Arg Ala Asn Asp His Glu Gly Val Lys Arg Thr Gly Lys
     530                 535                 540

 aca ctg tct agg cac aga acg cgc aac aca aac gac tgg cac cag cat     1680
 Thr Leu Ser Arg His Arg Thr Arg Asn Thr Asn Asp Trp His Gln His
 545                 550                 555                 560

 cga aga gat gat gga acc gat ccc gtg agg gcg aag ccc aga aca agc     1728
 Arg Arg Asp Asp Gly Thr Asp Pro Val Arg Ala Lys Pro Arg Thr Ser
                 565                 570                 575

 acg gcc gac cag act gag atc aac ggc gca tcc tgt aaa gaa ggg cga     1776
 Thr Ala Asp Gln Thr Glu Ile Asn Gly Ala Ser Cys Lys Glu Gly Arg
             580                 585                 590

 agt gac cag aag gcg tat gac gag aaa tca cgc gta tcg cga cct aca     1824
 Ser Asp Gln Lys Ala Tyr Asp Glu Lys Ser Arg Val Ser Arg Pro Thr
         595                 600                 605

 aac aag cca gct gga agc ctg aaa tcc atc gcc gcg agg atc ctg tcc     1872
 Asn Lys Pro Ala Gly Ser Leu Lys Ser Ile Ala Ala Arg Ile Leu Ser
     610                 615                 620

 cgt taa                                                             1878
 Arg 
 625





      <210> 722
      <211> 1335
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (1)..(1335)

      <400> 722
  atg ggc gtc ggg ggc ctg gcg ggt gca tgc atg ctg agg ggg ctg tcg      48
  Met Gly Val Gly Gly Leu Ala Gly Ala Cys Met Leu Arg Gly Leu Ser
    1               5                  10                  15

 gcg ggt ggg ctc act gag cgg aga agg atg aag cgg cga tac ccc cag       96
 Ala Gly Gly Leu Thr Glu Arg Arg Arg Met Lys Arg Arg Tyr Pro Gln
              20                  25                  30

 cac gag gct tct gct gca cag act cag gcg ctc cct ccc ctg gtg gca      144
 His Glu Ala Ser Ala Ala Gln Thr Gln Ala Leu Pro Pro Leu Val Ala
          35                  40                  45

 gtg agc tgg ggc ctg ctc agc acc ccc ggc ccc agg atg tgc ctg ctg      192
 Val Ser Trp Gly Leu Leu Ser Thr Pro Gly Pro Arg Met Cys Leu Leu
      50                  55                  60

 gtg cct gag aga gca gca gcc agg tct tct cca tac ttt gag gat atg      240
 Val Pro Glu Arg Ala Ala Ala Arg Ser Ser Pro Tyr Phe Glu Asp Met
  65                  70                  75                  80

 aaa gga gcc aga aca gaa ggg ggt tcc tgc agg gcc acc ggt gcc tca      288
 Lys Gly Ala Arg Thr Glu Gly Gly Ser Cys Arg Ala Thr Gly Ala Ser
                  85                  90                  95

 cac tgg cac caa ggc ctg ggg ctc gca gtg tcc gtg agg gcg tcc tgg      336
 His Trp His Gln Gly Leu Gly Leu Ala Val Ser Val Arg Ala Ser Trp
             100                 105                 110

 aag aga cag ggt tcc ccc aac cgc cac cag ctg ccc tgc cca gca tca      384
 Lys Arg Gln Gly Ser Pro Asn Arg His Gln Leu Pro Cys Pro Ala Ser
         115                 120                 125

 ggc ctg cag gat gat ttg aga caa cat tta gat aaa tct ttg gaa gag      432
 Gly Leu Gln Asp Asp Leu Arg Gln His Leu Asp Lys Ser Leu Glu Glu
     130                 135                 140

 aac agt agg tta aaa tcg ctt ttg ttg agt atg aaa aag gaa gtg aag      480
 Asn Ser Arg Leu Lys Ser Leu Leu Leu Ser Met Lys Lys Glu Val Lys
 145                 150                 155                 160

 agt gca gac act gca gcc acg tta aat ttg cag atc gct ggt aga ctt      528
 Ser Ala Asp Thr Ala Ala Thr Leu Asn Leu Gln Ile Ala Gly Arg Leu
                 165                 170                 175

 tgt ttt aaa ttc ttc act gag gga agt gag cag cag cag acg cag ttg      576
 Cys Phe Lys Phe Phe Thr Glu Gly Ser Glu Gln Gln Gln Thr Gln Leu
             180                 185                 190

 cac ggg gac tgg aag gtc ctg aag ctg tgc cgc cct gcg ctt cct tca      624
 His Gly Asp Trp Lys Val Leu Lys Leu Cys Arg Pro Ala Leu Pro Ser
         195                 200                 205

 ttc atg ccc tac gtg aac atg tcc atc gac ata gac ttc acg cgg cgt      672
 Phe Met Pro Tyr Val Asn Met Ser Ile Asp Ile Asp Phe Thr Arg Arg
     210                 215                 220

 ggc ctt cac act gtg gat gct cct gcg gca ctg ctg cct tgt ggg act      720
 Gly Leu His Thr Val Asp Ala Pro Ala Ala Leu Leu Pro Cys Gly Thr
 225                 230                 235                 240

 tca aac aag tgt gaa gag gct gtg tgg cga gat tgt gga act gaa gca      768
 Ser Asn Lys Cys Glu Glu Ala Val Trp Arg Asp Cys Gly Thr Glu Ala
                 245                 250                 255

 gca cct gga gca cta cga caa gat cca gga gct cac gca gat gct gca      816
 Ala Pro Gly Ala Leu Arg Gln Asp Pro Gly Ala His Ala Asp Ala Ala
             260                 265                 270

 gga gag cca cag gtg cct gcc cgt gag act tgg gtg ggc ccc cga ggg      864
 Gly Glu Pro Gln Val Pro Ala Arg Glu Thr Trp Val Gly Pro Arg Gly
         275                 280                 285

 gag gag gcc cag gtc aag gta cag ttg ggg gtc att ctc ctt gag cac      912
 Glu Glu Ala Gln Val Lys Val Gln Leu Gly Val Ile Leu Leu Glu His
     290                 295                 300

 tgt ggc ctg gat gtg gac aag gca ggg tgc aca gct ccc aaa cat ggt      960
 Cys Gly Leu Asp Val Asp Lys Ala Gly Cys Thr Ala Pro Lys His Gly
 305                 310                 315                 320

 ggc att ggg ctt ctg ccc cca gga ttc atg ctg gct tca tcc agt cct     1008
 Gly Ile Gly Leu Leu Pro Pro Gly Phe Met Leu Ala Ser Ser Ser Pro
                 325                 330                 335

 ggc ctg cgg ctc ctt tgc tgt cca agt gaa cag ggc ctg ggc ctg cac     1056
 Gly Leu Arg Leu Leu Cys Cys Pro Ser Glu Gln Gly Leu Gly Leu His
             340                 345                 350

 agt ggc cct gtc agt ggg gtg ccc atc tct gtg gct aat gtg acc gag     1104
 Ser Gly Pro Val Ser Gly Val Pro Ile Ser Val Ala Asn Val Thr Glu
         355                 360                 365

 gtg ttg agc cgc acc tcc aag gct gct ccc agg ggt cag gac agt ggt     1152
 Val Leu Ser Arg Thr Ser Lys Ala Ala Pro Arg Gly Gln Asp Ser Gly
     370                 375                 380

 tgg gaa gga gga ggc agc tcc ctg gtc agc acc aat gaa cac ctg ctg     1200
 Trp Glu Gly Gly Gly Ser Ser Leu Val Ser Thr Asn Glu His Leu Leu
 385                 390                 395                 400

 cag gag ctg agc cag gtg cgg gcg cag cac aga gcc gag gtg gag cag     1248
 Gln Glu Leu Ser Gln Val Arg Ala Gln His Arg Ala Glu Val Glu Gln
                 405                 410                 415

 atg cac tgg agc tac cag gag ctc aag aag acc atg gcc ctg ttt cca     1296
 Met His Trp Ser Tyr Gln Glu Leu Lys Lys Thr Met Ala Leu Phe Pro
             420                 425                 430

 cac agc agc gcc agc cat gga ggc tgc cag gcc tgc tga                 1335
 His Ser Ser Ala Ser His Gly Gly Cys Gln Ala Cys 
         435                 440





      <210> 723
      <211> 627
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (1)..(627)

      <400> 723
  atg cgc cct gca gcc ctg cgc ggg gcc ctg ctg ggc tgc ctc tgc ctg      48
  Met Arg Pro Ala Ala Leu Arg Gly Ala Leu Leu Gly Cys Leu Cys Leu
    1               5                  10                  15

 gcg ttg ctt tgc ctg ggc ggt gcg gac aag cgc ctg cgt gcg tca gtg       96
 Ala Leu Leu Cys Leu Gly Gly Ala Asp Lys Arg Leu Arg Ala Ser Val
              20                  25                  30

 tcc agg ccc ttc tca ttg gag cac cca gag cca gga cac tgc ctg gat      144
 Ser Arg Pro Phe Ser Leu Glu His Pro Glu Pro Gly His Cys Leu Asp
          35                  40                  45

 ctg cac ctc agg gcg tac cct gct cgg tgt gtc aag ctg acc ctg gcc      192
 Leu His Leu Arg Ala Tyr Pro Ala Arg Cys Val Lys Leu Thr Leu Ala
      50                  55                  60

 cca gga ctt ctg ggt cag atg acc gac gtg gga atc tgg tcg gat ctt      240
 Pro Gly Leu Leu Gly Gln Met Thr Asp Val Gly Ile Trp Ser Asp Leu
  65                  70                  75                  80

 ttg cca gaa atg agg gca tac tgg cct gac gta att cac tcg ttt ccc      288
 Leu Pro Glu Met Arg Ala Tyr Trp Pro Asp Val Ile His Ser Phe Pro
                  85                  90                  95

 aat cgc agc cgc ttc tgg aag cat gag tgg gaa aag cat ggg acc tgc      336
 Asn Arg Ser Arg Phe Trp Lys His Glu Trp Glu Lys His Gly Thr Cys
             100                 105                 110

 gcc gcc cag gtg gat gcg ctc aac tcc cag aag aag tac ttt ggc aga      384
 Ala Ala Gln Val Asp Ala Leu Asn Ser Gln Lys Lys Tyr Phe Gly Arg
         115                 120                 125

 agc ctg gaa ctc tac agg gag ctg gac ctc aac agg ggt gag cga gtt      432
 Ser Leu Glu Leu Tyr Arg Glu Leu Asp Leu Asn Arg Gly Glu Arg Val
     130                 135                 140

 ccc act cag ttc ccc aga gag ctg gtt gtt aac agg agc ctg gca ccg      480
 Pro Thr Gln Phe Pro Arg Glu Leu Val Val Asn Arg Ser Leu Ala Pro
 145                 150                 155                 160

 ccc cca acc cct ggc ttc ctc tct ggc cat gtg atc tct gta cac acc      528
 Pro Pro Thr Pro Gly Phe Leu Ser Gly His Val Ile Ser Val His Thr
                 165                 170                 175

 agc tcc cct ttg cct tct gcc atg agc gga agt ttc ctg agg ccc ttg      576
 Ser Ser Pro Leu Pro Ser Ala Met Ser Gly Ser Phe Leu Arg Pro Leu
             180                 185                 190

 cca gaa gca gaa tct ggt tcc atg ctt ctc gga cag cct gca gac ccc      624
 Pro Glu Ala Glu Ser Gly Ser Met Leu Leu Gly Gln Pro Ala Asp Pro
         195                 200                 205

 tga                                                                  627
 






      <210> 724
      <211> 1305
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (1)..(1305)

      <400> 724
  atg gaa tgc tgg tgc tcc ctc ctc ctg ggg tgg ggt ctg ccg ccc gct      48
  Met Glu Cys Trp Cys Ser Leu Leu Leu Gly Trp Gly Leu Pro Pro Ala
    1               5                  10                  15

 ggc ctc ctg gcg gtt agg aac cca aac ttc cat gag gcc cag gac act       96
 Gly Leu Leu Ala Val Arg Asn Pro Asn Phe His Glu Ala Gln Asp Thr
              20                  25                  30

 ccc aga agg cac cac acg aca cag atg gat gcc agc aag atc atc atg      144
 Pro Arg Arg His His Thr Thr Gln Met Asp Ala Ser Lys Ile Ile Met
          35                  40                  45

 gac tgg aaa tgg atg gcg ggg gat gcc agc aag atc atc atg gac tgg      192
 Asp Trp Lys Trp Met Ala Gly Asp Ala Ser Lys Ile Ile Met Asp Trp
      50                  55                  60

 aaa tgg atg gcg ggg gat gcc agc aag atc atc atg gac tgg aaa tgg      240
 Lys Trp Met Ala Gly Asp Ala Ser Lys Ile Ile Met Asp Trp Lys Trp
  65                  70                  75                  80

 atg gcg ggg gat gcc agc gtc aag gcc acc ccc aga gcc aag gag ggc      288
 Met Ala Gly Asp Ala Ser Val Lys Ala Thr Pro Arg Ala Lys Glu Gly
                  85                  90                  95

 agg cag ccc tgg gac cct ctt cag gca ccg cag cca ggg tct gtg tta      336
 Arg Gln Pro Trp Asp Pro Leu Gln Ala Pro Gln Pro Gly Ser Val Leu
             100                 105                 110

 ccc aca ggt cct ctg gat gtc agc atg gca gcc aca aac ctg gag aac      384
 Pro Thr Gly Pro Leu Asp Val Ser Met Ala Ala Thr Asn Leu Glu Asn
         115                 120                 125

 cag ctg cac agc gca cag aag aac ctc ctg ttc ctt cag cgg gag cat      432
 Gln Leu His Ser Ala Gln Lys Asn Leu Leu Phe Leu Gln Arg Glu His
     130                 135                 140

 gcc agc acg ctc aag ggg ctg cac tcc gag atc agg cgg ctg cag cag      480
 Ala Ser Thr Leu Lys Gly Leu His Ser Glu Ile Arg Arg Leu Gln Gln
 145                 150                 155                 160

 cac tgc aca gat tta aca tat gag ctg aca gtc aaa agt tcg gaa cag      528
 His Cys Thr Asp Leu Thr Tyr Glu Leu Thr Val Lys Ser Ser Glu Gln
                 165                 170                 175

 aca gga gac ggg act tct aaa agc agt gaa tta aag aaa aga tgt gaa      576
 Thr Gly Asp Gly Thr Ser Lys Ser Ser Glu Leu Lys Lys Arg Cys Glu
             180                 185                 190

 gag ctg gaa gcc caa ctg aaa gtg aaa gag aac gaa aat gct gag ttg      624
 Glu Leu Glu Ala Gln Leu Lys Val Lys Glu Asn Glu Asn Ala Glu Leu
         195                 200                 205

 ttg aaa gaa ctg gag cag aaa aac gcg atg atc aca gtg ctg gag aac      672
 Leu Lys Glu Leu Glu Gln Lys Asn Ala Met Ile Thr Val Leu Glu Asn
     210                 215                 220

 acc atc aag gag cga gag aag aag tac ctg gag gag ctg aag gcc aag      720
 Thr Ile Lys Glu Arg Glu Lys Lys Tyr Leu Glu Glu Leu Lys Ala Lys
 225                 230                 235                 240

 agt cac aag ctg acc ctg ctg tct agc gag ctg gag cag cgg gcc agc      768
 Ser His Lys Leu Thr Leu Leu Ser Ser Glu Leu Glu Gln Arg Ala Ser
                 245                 250                 255

 acc atc gcc tac ctg acc tcc cag ctg cac gcc gcc aag aag aag ctc      816
 Thr Ile Ala Tyr Leu Thr Ser Gln Leu His Ala Ala Lys Lys Lys Leu
             260                 265                 270

 atg agc tcc agc ggg acc tca gat gcc agc ccg tca ggg agc ccc gtg      864
 Met Ser Ser Ser Gly Thr Ser Asp Ala Ser Pro Ser Gly Ser Pro Val
         275                 280                 285

 ctg gcc agc tac aag cca gcg ccc ccc aaa gac aag cta ccc gaa acg      912
 Leu Ala Ser Tyr Lys Pro Ala Pro Pro Lys Asp Lys Leu Pro Glu Thr
     290                 295                 300

 cct cgc cgc cgc atg aaa aag agc ctc tca gcc ccc ttg cac ccg gaa      960
 Pro Arg Arg Arg Met Lys Lys Ser Leu Ser Ala Pro Leu His Pro Glu
 305                 310                 315                 320

 ttt gaa gag gtc tac aga ttc ggg gca gag agc agg aaa ctc ctt ttg     1008
 Phe Glu Glu Val Tyr Arg Phe Gly Ala Glu Ser Arg Lys Leu Leu Leu
                 325                 330                 335

 cgg gaa cca gtg gat gct atg ccc gac ccc acc cca ttt ctg ctg gct     1056
 Arg Glu Pro Val Asp Ala Met Pro Asp Pro Thr Pro Phe Leu Leu Ala
             340                 345                 350

 agg gag tcc gcc gag gtc cac ctc atc aaa gag agg ccc ctc gtc atc     1104
 Arg Glu Ser Ala Glu Val His Leu Ile Lys Glu Arg Pro Leu Val Ile
         355                 360                 365

 ccc ccc atc gcc tcc gac cga agc ggc gag cag cac agc ccg gcc cgc     1152
 Pro Pro Ile Ala Ser Asp Arg Ser Gly Glu Gln His Ser Pro Ala Arg
     370                 375                 380

 gaa aag ccg cac aag gcc cac gtc ggg gtg gca cat cgg atc cac cac     1200
 Glu Lys Pro His Lys Ala His Val Gly Val Ala His Arg Ile His His
 385                 390                 395                 400

 gcc acc ccg ccg cag gcc cag ccc gag gtg aag acc ctg gcg gtc gac     1248
 Ala Thr Pro Pro Gln Ala Gln Pro Glu Val Lys Thr Leu Ala Val Asp
                 405                 410                 415

 cag gtg aac gga ggc aag gtg gtg agg aag cac tca ggg acg gac aga     1296
 Gln Val Asn Gly Gly Lys Val Val Arg Lys His Ser Gly Thr Asp Arg
             420                 425                 430

 act gtg tga                                                         1305
 Thr Val 






      <210> 725
      <211> 821
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (24)..(821)

      <400> 725
 gggcttttgg tcatgggtat gat    atg cac ttg tgg cca cct gaa atc ctg      50
                              Met His Leu Trp Pro Pro Glu Ile Leu
                                1               5

 ttc cta atg ctg tta gat ttt cct ttt cag agt aag agg gac cat ctc       98
 Phe Leu Met Leu Leu Asp Phe Pro Phe Gln Ser Lys Arg Asp His Leu
  10                  15                  20                  25

 ctc atg aac gtc aaa tgg tac tac cgt caa tct gag gtt cca gat tct      146
 Leu Met Asn Val Lys Trp Tyr Tyr Arg Gln Ser Glu Val Pro Asp Ser
                  30                  35                  40

 gtg tat cag cat ttg gtt cag gat cga cat aat gaa aat gac tct gga      194
 Val Tyr Gln His Leu Val Gln Asp Arg His Asn Glu Asn Asp Ser Gly
              45                  50                  55

 aga gaa ctt gtc att aca gac cca gtt atc aag aac cga gag ctc ttc      242
 Arg Glu Leu Val Ile Thr Asp Pro Val Ile Lys Asn Arg Glu Leu Phe
          60                  65                  70

 att tct gat tac gtt gac act tac cat gct gct gcc ctt aga aaa tct      290
 Ile Ser Asp Tyr Val Asp Thr Tyr His Ala Ala Ala Leu Arg Lys Ser
      75                  80                  85

 gag ccc ttc gca gtt gta gaa atg tgt gtt gaa gtt cag cat tac tgc      338
 Glu Pro Phe Ala Val Val Glu Met Cys Val Glu Val Gln His Tyr Cys
  90                  95                 100                 105

 att gct gtt agt ttt gaa ttc ttg acc tta gct atc cct tat ctc tac      386
 Ile Ala Val Ser Phe Glu Phe Leu Thr Leu Ala Ile Pro Tyr Leu Tyr
                 110                 115                 120

 ctt tca aga ggg aag tgt aac atc tcc cat ttt tct gac ata ttt gct      434
 Leu Ser Arg Gly Lys Cys Asn Ile Ser His Phe Ser Asp Ile Phe Ala
             125                 130                 135

 gct aga gag ttt aaa gcc cga gtg gat tca ttt ttc tac ata tta gga      482
 Ala Arg Glu Phe Lys Ala Arg Val Asp Ser Phe Phe Tyr Ile Leu Gly
         140                 145                 150

 tat aac cct gag aca aga agt gct aat cct aca cct gtt gtt cac ttg      530
 Tyr Asn Pro Glu Thr Arg Ser Ala Asn Pro Thr Pro Val Val His Leu
     155                 160                 165

 gga tta ata gga gga gag aag gat gtc tgg gat cca gag att ata gat      578
 Gly Leu Ile Gly Gly Glu Lys Asp Val Trp Asp Pro Glu Ile Ile Asp
 170                 175                 180                 185

 gta cat ggg gat cac agg act tct ggg aag gcc ttg gca gtt ggc aac      626
 Val His Gly Asp His Arg Thr Ser Gly Lys Ala Leu Ala Val Gly Asn
                 190                 195                 200

 aga tgg aaa tac gag ggt gcc agg ttg cag att gta tgt aca tcc ctg      674
 Arg Trp Lys Tyr Glu Gly Ala Arg Leu Gln Ile Val Cys Thr Ser Leu
             205                 210                 215

 cag gct ggc aaa cga tgg gct aga aaa tgt ggt ggc agg agt gag gtc      722
 Gln Ala Gly Lys Arg Trp Ala Arg Lys Cys Gly Gly Arg Ser Glu Val
         220                 225                 230

 cag gtg ggt agt cag cat cag tac aca ggc agc ccg tgt tca aga gaa      770
 Gln Val Gly Ser Gln His Gln Tyr Thr Gly Ser Pro Cys Ser Arg Glu
     235                 240                 245

 cta gga gag aaa aca agg ccc ctc tct ggg atg ccc tta agc act gag      818
 Leu Gly Glu Lys Thr Arg Pro Leu Ser Gly Met Pro Leu Ser Thr Glu
 250                 255                 260                 265

 tag                                                                  821
 






      <210> 726
      <211> 654
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (1)..(654)

      <400> 726
  atg agg caa aac ttc gta gcc caa ttt gtt caa ctt ttg aag cgt tgg      48
  Met Arg Gln Asn Phe Val Ala Gln Phe Val Gln Leu Leu Lys Arg Trp
    1               5                  10                  15

 ttg tgt gac att cag tca ggc act gtc gtg gag aag aat tgg gcc ctt       96
 Leu Cys Asp Ile Gln Ser Gly Thr Val Val Glu Lys Asn Trp Ala Leu
              20                  25                  30

 tct gtt gac cga tgc cgg ctg cag aca ttg cag ttt ttg atg cat ctc      144
 Ser Val Asp Arg Cys Arg Leu Gln Thr Leu Gln Phe Leu Met His Leu
          35                  40                  45

 att gat ttg ccg aac ata ctt ctc aga tgt act ggt ttg gcc agg att      192
 Ile Asp Leu Pro Asn Ile Leu Leu Arg Cys Thr Gly Leu Ala Arg Ile
      50                  55                  60

 cag aaa gct gta gtg gat caa acc agc agc agg cca cca aag agt gac      240
 Gln Lys Ala Val Val Asp Gln Thr Ser Ser Arg Pro Pro Lys Ser Asp
  65                  70                  75                  80

 ctg gga tct ttc tgt gct tgc acg agt tct aac aat aac acc tac tgg      288
 Leu Gly Ser Phe Cys Ala Cys Thr Ser Ser Asn Asn Asn Thr Tyr Trp
                  85                  90                  95

 tgt ttg cgt aca gtt aat gag acg cat aat ttt ctt ttc tgt gag ttt      336
 Cys Leu Arg Thr Val Asn Glu Thr His Asn Phe Leu Phe Cys Glu Phe
             100                 105                 110

 gct act ggc ttt ttg gag tat ttt gat atg aat aca gat cct tat cag      384
 Ala Thr Gly Phe Leu Glu Tyr Phe Asp Met Asn Thr Asp Pro Tyr Gln
         115                 120                 125

 ctc aca aat aca gtg cac acg gta gaa cga ggc att ttg aat cag cta      432
 Leu Thr Asn Thr Val His Thr Val Glu Arg Gly Ile Leu Asn Gln Leu
     130                 135                 140

 cac gta caa cta atg gag ctc aga agc tgt caa gga tat aag cag tgc      480
 His Val Gln Leu Met Glu Leu Arg Ser Cys Gln Gly Tyr Lys Gln Cys
 145                 150                 155                 160

 aac cca aga cct aag aat ctt gat gtt gag aac ttt gat gga aag aca      528
 Asn Pro Arg Pro Lys Asn Leu Asp Val Glu Asn Phe Asp Gly Lys Thr
                 165                 170                 175

 caa tgc tct att tct gct gtc cca gtt tgg agt tcc ccc agt tgg atc      576
 Gln Cys Ser Ile Ser Ala Val Pro Val Trp Ser Ser Pro Ser Trp Ile
             180                 185                 190

 cct gcc tat gac act gaa tta gat ttc ttt tgc cag tat ttt tcg tct      624
 Pro Ala Tyr Asp Thr Glu Leu Asp Phe Phe Cys Gln Tyr Phe Ser Ser
         195                 200                 205

 gaa act aga gat att gga gca gtt cat taa                              654
 Glu Thr Arg Asp Ile Gly Ala Val His 
     210                 215





      <210> 727
      <211> 540
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (1)..(540)

      <400> 727
  atg aag gga ccc ctg gtc tgg gct ggg gat ttg ggg ggc tcc ttc tgc      48
  Met Lys Gly Pro Leu Val Trp Ala Gly Asp Leu Gly Gly Ser Phe Cys
    1               5                  10                  15

 atc ctc tcc ctc acc cta ctg ctc tca gtg gtg tct gcc ctg gaa ccg       96
 Ile Leu Ser Leu Thr Leu Leu Leu Ser Val Val Ser Ala Leu Glu Pro
              20                  25                  30

 aag gca gtg tgg cct gag tac aag gaa tgc ttc tcc ctg tat gac aag      144
 Lys Ala Val Trp Pro Glu Tyr Lys Glu Cys Phe Ser Leu Tyr Asp Lys
          35                  40                  45

 cag cag agg ggg aag ata aaa gcc acc gac ctc atg gtg gcc atg agg      192
 Gln Gln Arg Gly Lys Ile Lys Ala Thr Asp Leu Met Val Ala Met Arg
      50                  55                  60

 tgc ctg ggg gcc agc ccg acg cca ggg gag gtg cag cgg cac ctg cag      240
 Cys Leu Gly Ala Ser Pro Thr Pro Gly Glu Val Gln Arg His Leu Gln
  65                  70                  75                  80

 acc cac ggg ata gac gga aat gga gag ctg gat ttc tcc act ttt ctg      288
 Thr His Gly Ile Asp Gly Asn Gly Glu Leu Asp Phe Ser Thr Phe Leu
                  85                  90                  95

 acc att atg cac atg caa ata aaa caa gaa gac cca aag aaa gaa att      336
 Thr Ile Met His Met Gln Ile Lys Gln Glu Asp Pro Lys Lys Glu Ile
             100                 105                 110

 ctt cta gcc atg ttg atg gtg gac aag gag aag aaa ggt tac gtc atg      384
 Leu Leu Ala Met Leu Met Val Asp Lys Glu Lys Lys Gly Tyr Val Met
         115                 120                 125

 gcg tcc gac ctg cgg tca aaa ctc acg agt ctg ggg gag aag ctc acc      432
 Ala Ser Asp Leu Arg Ser Lys Leu Thr Ser Leu Gly Glu Lys Leu Thr
     130                 135                 140

 cac aag gaa gtg gat gat ctc ttc agg gaa gca gat atc gaa ccc aat      480
 His Lys Glu Val Asp Asp Leu Phe Arg Glu Ala Asp Ile Glu Pro Asn
 145                 150                 155                 160

 ggc aaa gtg aag tat gat gaa ttt atc cac aag atc acc ctt cct gga      528
 Gly Lys Val Lys Tyr Asp Glu Phe Ile His Lys Ile Thr Leu Pro Gly
                 165                 170                 175

 cgg gac tat tga                                                      540
 Arg Asp Tyr 






      <210> 728
      <211> 1287
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (1)..(1287)

      <400> 728
  atg gct caa aag caa tta agg ctt aca gtt aca ttt ctc act tcc tat      48
  Met Ala Gln Lys Gln Leu Arg Leu Thr Val Thr Phe Leu Thr Ser Tyr
    1               5                  10                  15

 ttc atg aaa atg ctg aat ctc aga ttt agt ccc ttt ttc tta atc ttt       96
 Phe Met Lys Met Leu Asn Leu Arg Phe Ser Pro Phe Phe Leu Ile Phe
              20                  25                  30

 agc agt gac ctg gtt caa gag cta aga ctg aag gtc ctg gtc agg ttt      144
 Ser Ser Asp Leu Val Gln Glu Leu Arg Leu Lys Val Leu Val Arg Phe
          35                  40                  45

 aag gac tta gaa ggt gtt gcc tct gga gga ggg aca ggt gga agt gaa      192
 Lys Asp Leu Glu Gly Val Ala Ser Gly Gly Gly Thr Gly Gly Ser Glu
      50                  55                  60

 atg act ttt aca aaa ttt caa ggc cag aga atg gca ggg gaa cag aaa      240
 Met Thr Phe Thr Lys Phe Gln Gly Gln Arg Met Ala Gly Glu Gln Lys
  65                  70                  75                  80

 ccc tca agt aat ctc ctg gag cag ttt att tta cta gcc aaa ggt acc      288
 Pro Ser Ser Asn Leu Leu Glu Gln Phe Ile Leu Leu Ala Lys Gly Thr
                  85                  90                  95

 agt ggc tca gcc ctc act gct ctc ata agc cag gtc tta gag gct ccc      336
 Ser Gly Ser Ala Leu Thr Ala Leu Ile Ser Gln Val Leu Glu Ala Pro
             100                 105                 110

 gga gtg tat gtc ttt gga gaa ctt ctg gag ctg gcc aac gtg cag gag      384
 Gly Val Tyr Val Phe Gly Glu Leu Leu Glu Leu Ala Asn Val Gln Glu
         115                 120                 125

 ctt gcg gaa gga gct aat gct gct tat ttg cag ttg ttg aac ctg ttt      432
 Leu Ala Glu Gly Ala Asn Ala Ala Tyr Leu Gln Leu Leu Asn Leu Phe
     130                 135                 140

 gcc tat ggg aca tac cca gat tac ata gag gca gct gtt ggc tat ggg      480
 Ala Tyr Gly Thr Tyr Pro Asp Tyr Ile Glu Ala Ala Val Gly Tyr Gly
 145                 150                 155                 160

 agt aat acc tgc att ttc gct aat gct tgc cag atg gtt ttt ata atg      528
 Ser Asn Thr Cys Ile Phe Ala Asn Ala Cys Gln Met Val Phe Ile Met
                 165                 170                 175

 atc aca tgg cct tat cta cag tgt atc ccc tac tcc gtg ttg ctg aaa      576
 Ile Thr Trp Pro Tyr Leu Gln Cys Ile Pro Tyr Ser Val Leu Leu Lys
             180                 185                 190

 gac ctg gag atg cgg aat ctc cgg gaa cta gaa gac ctt atc att gag      624
 Asp Leu Glu Met Arg Asn Leu Arg Glu Leu Glu Asp Leu Ile Ile Glu
         195                 200                 205

 gct gtc tac act gac atc atc cag ggc aag ctg gac cag cga aac cag      672
 Ala Val Tyr Thr Asp Ile Ile Gln Gly Lys Leu Asp Gln Arg Asn Gln
     210                 215                 220

 ctg ctg gaa gtg gat ttc tgc att ggc cgt gac atc cga aag aag gat      720
 Leu Leu Glu Val Asp Phe Cys Ile Gly Arg Asp Ile Arg Lys Lys Asp
 225                 230                 235                 240

 atc aat aat att gtc aag acc ctg cat gaa tgg tgt gat ggc tgt gaa      768
 Ile Asn Asn Ile Val Lys Thr Leu His Glu Trp Cys Asp Gly Cys Glu
                 245                 250                 255

 gca gtt cta ctg ggc atc gag cag caa gtt ctg aga gcc aac cag tac      816
 Ala Val Leu Leu Gly Ile Glu Gln Gln Val Leu Arg Ala Asn Gln Tyr
             260                 265                 270

 aaa gag aac cac aac cga act cag cag cag gta gaa gca gag gca tac      864
 Lys Glu Asn His Asn Arg Thr Gln Gln Gln Val Glu Ala Glu Ala Tyr
         275                 280                 285

 ctg ttt att cgt ttg cag tgt tta tgt ttt tgt ttt gcg aat ctt ggt      912
 Leu Phe Ile Arg Leu Gln Cys Leu Cys Phe Cys Phe Ala Asn Leu Gly
     290                 295                 300

 gta gat gaa aca agc agt cac caa caa gat gtt tac att ttg cct caa      960
 Val Asp Glu Thr Ser Ser His Gln Gln Asp Val Tyr Ile Leu Pro Gln
 305                 310                 315                 320

 agt ggt aac gac tgt aga gga ctt aga ttt gtc agc agt ctt att gga     1008
 Ser Gly Asn Asp Cys Arg Gly Leu Arg Phe Val Ser Ser Leu Ile Gly
                 325                 330                 335

 gga gtg agg tgt gtg cat ctg aaa cac aaa gga gat gca gtg gtg tgg     1056
 Gly Val Arg Cys Val His Leu Lys His Lys Gly Asp Ala Val Val Trp
             340                 345                 350

 gag gcc atc gaa gag gga gag gca ctg cca ggc aag tac aga ttg aag     1104
 Glu Ala Ile Glu Glu Gly Glu Ala Leu Pro Gly Lys Tyr Arg Leu Lys
         355                 360                 365

 ggt ggc aga tca gtg tgg gct gca gca gtc agg gca gtt tgt atg gac     1152
 Gly Gly Arg Ser Val Trp Ala Ala Ala Val Arg Ala Val Cys Met Asp
     370                 375                 380

 cag gtg ctc aac tct cca ggc agg atc aga ggg gca acc tgg gga gga     1200
 Gln Val Leu Asn Ser Pro Gly Arg Ile Arg Gly Ala Thr Trp Gly Gly
 385                 390                 395                 400

 gcg gta acc ccc ggg gtg cat gaa caa cag aag ggc ata ggg gga atg     1248
 Ala Val Thr Pro Gly Val His Glu Gln Gln Lys Gly Ile Gly Gly Met
                 405                 410                 415

 act gct tcc aag tgt ggt gtg ggg gac gag tgt ggc tga                 1287
 Thr Ala Ser Lys Cys Gly Val Gly Asp Glu Cys Gly 
             420                 425





      <210> 729
      <211> 900
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (1)..(900)

      <400> 729
  atg gct ctg aag atg agg aga gaa gcg gga tgg gca gtt tgt gtg gtg      48
  Met Ala Leu Lys Met Arg Arg Glu Ala Gly Trp Ala Val Cys Val Val
    1               5                  10                  15

 agg agg ctg gct gca gct ccg gcc gcc gcc gcc gcc gcc gcc gcc tcc       96
 Arg Arg Leu Ala Ala Ala Pro Ala Ala Ala Ala Ala Ala Ala Ala Ser
              20                  25                  30

 ttc ttg cat gac aca gca gaa ccg cag ctg ctg cag caa ttt caa gcc      144
 Phe Leu His Asp Thr Ala Glu Pro Gln Leu Leu Gln Gln Phe Gln Ala
          35                  40                  45

 atc cgc cca gga agc gcc gca acc ggg act cgg gag ggc cca ggg gca      192
 Ile Arg Pro Gly Ser Ala Ala Thr Gly Thr Arg Glu Gly Pro Gly Ala
      50                  55                  60

 cgc gaa caa aat gag gct caa gct gac cag gcc gag ccg gag gaa cgc      240
 Arg Glu Gln Asn Glu Ala Gln Ala Asp Gln Ala Glu Pro Glu Glu Arg
  65                  70                  75                  80

 tgg ggc ttg gca gca gaa ggg atg gga cca gag aga agg gtg tgg agg      288
 Trp Gly Leu Ala Ala Glu Gly Met Gly Pro Glu Arg Arg Val Trp Arg
                  85                  90                  95

 aga ccc cac aca ggc tcc acg cac gca cag aca cca cgg ctc ccg gat      336
 Arg Pro His Thr Gly Ser Thr His Ala Gln Thr Pro Arg Leu Pro Asp
             100                 105                 110

 gct gtg gct ccc cga tcg ggg ctc ctg cag cgc cag aag ccc ctc cgg      384
 Ala Val Ala Pro Arg Ser Gly Leu Leu Gln Arg Gln Lys Pro Leu Arg
         115                 120                 125

 gat gct tcg agg ggc tcc cgg tgg gtg gag ggc gtg aag aag gcg tcc      432
 Asp Ala Ser Arg Gly Ser Arg Trp Val Glu Gly Val Lys Lys Ala Ser
     130                 135                 140

 cct ccg ctg ccg gcg gag ctg atc ggc tgg cta gtc aat ttc ccc tta      480
 Pro Pro Leu Pro Ala Glu Leu Ile Gly Trp Leu Val Asn Phe Pro Leu
 145                 150                 155                 160

 gca cgc ccc gtg cgc cca ccc tcg ctc agc ccg ggg ccc cct cgc cgt      528
 Ala Arg Pro Val Arg Pro Pro Ser Leu Ser Pro Gly Pro Pro Arg Arg
                 165                 170                 175

 ccc ccg gaa ggg gtc tgc ggt tcc tgg cca gga cgt tcg gaa ggc gag      576
 Pro Pro Glu Gly Val Cys Gly Ser Trp Pro Gly Arg Ser Glu Gly Glu
             180                 185                 190

 cgg ggg aag gct aaa aac aca gct gaa agc acc cca aga caa aac tta      624
 Arg Gly Lys Ala Lys Asn Thr Ala Glu Ser Thr Pro Arg Gln Asn Leu
         195                 200                 205

 cac aga aaa tac aca ata ata gta aca cat tat caa aga aat agg aag      672
 His Arg Lys Tyr Thr Ile Ile Val Thr His Tyr Gln Arg Asn Arg Lys
     210                 215                 220

 ggg caa aat atc agt ttt tca ctt gtt tgc gaa ttt cat cct tca ctg      720
 Gly Gln Asn Ile Ser Phe Ser Leu Val Cys Glu Phe His Pro Ser Leu
 225                 230                 235                 240

 gcc gat tgg acg act gtg aca gcg tta act tgg aca tcc cct aaa gat      768
 Ala Asp Trp Thr Thr Val Thr Ala Leu Thr Trp Thr Ser Pro Lys Asp
                 245                 250                 255

 aac agc ctc acg gaa gaa tca tgg ttg cgg gaa gga aat gtc cat cgg      816
 Asn Ser Leu Thr Glu Glu Ser Trp Leu Arg Glu Gly Asn Val His Arg
             260                 265                 270

 ggc atg gat gag tac gtc agg gca cag tca ttc ctg att ttg atg acc      864
 Gly Met Asp Glu Tyr Val Arg Ala Gln Ser Phe Leu Ile Leu Met Thr
         275                 280                 285

 ttg gag aac agt ggt ggc tct gta gtt tct aaa tga                      900
 Leu Glu Asn Ser Gly Gly Ser Val Val Ser Lys 
     290                 295





      <210> 730
      <211> 1104
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (1)..(1104)

      <400> 730
  atg cag ctc cca ctg gcc ctg tgt ctc gtc tgc ctg ctg gta cac aca      48
  Met Gln Leu Pro Leu Ala Leu Cys Leu Val Cys Leu Leu Val His Thr
    1               5                  10                  15

 gcc ttc cgt gta gtg gag ggc cag ggg tgg cag gcg ttc aag aat gat       96
 Ala Phe Arg Val Val Glu Gly Gln Gly Trp Gln Ala Phe Lys Asn Asp
              20                  25                  30

 gcc acg gaa atc atc ccc gag ctc gga gag tac ccc gag cct cca ccg      144
 Ala Thr Glu Ile Ile Pro Glu Leu Gly Glu Tyr Pro Glu Pro Pro Pro
          35                  40                  45

 gag ctg gag aac aac aag acc atg aac cgg gcg gag aac gga ggg cgg      192
 Glu Leu Glu Asn Asn Lys Thr Met Asn Arg Ala Glu Asn Gly Gly Arg
      50                  55                  60

 cct ccc cac cac ccc ttt gag acc aaa gca ctg gtc gag gaa cag tct      240
 Pro Pro His His Pro Phe Glu Thr Lys Ala Leu Val Glu Glu Gln Ser
  65                  70                  75                  80

 tgc ctg gag gtg ggg gaa gaa tgg ctc gct ggt gca gcc ttc aaa ttc      288
 Cys Leu Glu Val Gly Glu Glu Trp Leu Ala Gly Ala Ala Phe Lys Phe
                  85                  90                  95

 agg tgc aga ggc atg agg caa cag acg ctg gtg aga gcc cag ggc agg      336
 Arg Cys Arg Gly Met Arg Gln Gln Thr Leu Val Arg Ala Gln Gly Arg
             100                 105                 110

 gag gac gct ggg gtg gtg agg gta tgg cat cag ggc atc aga aca ggc      384
 Glu Asp Ala Gly Val Val Arg Val Trp His Gln Gly Ile Arg Thr Gly
         115                 120                 125

 tca ggg gct cag aaa aga aaa ggt ttc aaa gaa tct cct cct ggg aat      432
 Ser Gly Ala Gln Lys Arg Lys Gly Phe Lys Glu Ser Pro Pro Gly Asn
     130                 135                 140

 ata gga gcc acg tcc agc tgc tgg tac cac tgg gaa ggg aac aag gtg      480
 Ile Gly Ala Thr Ser Ser Cys Trp Tyr His Trp Glu Gly Asn Lys Val
 145                 150                 155                 160

 gca gag aag tcc act gcc cag gct cct gga ccc cag ccc tcc ccg cct      528
 Ala Glu Lys Ser Thr Ala Gln Ala Pro Gly Pro Gln Pro Ser Pro Pro
                 165                 170                 175

 cac aac ctg ttg gga cta tgg ggt gct aaa aag ggc aac tgc atg gga      576
 His Asn Leu Leu Gly Leu Trp Gly Ala Lys Lys Gly Asn Cys Met Gly
             180                 185                 190

 ggc cag cca gga ccc tcc gtc ttc aaa atg gag gac aag ggc gcc tcc      624
 Gly Gln Pro Gly Pro Ser Val Phe Lys Met Glu Asp Lys Gly Ala Ser
         195                 200                 205

 ccc cac agc tcc cct tct agg caa ggt cag ctg ggc tcc agc gac tgc      672
 Pro His Ser Ser Pro Ser Arg Gln Gly Gln Leu Gly Ser Ser Asp Cys
     210                 215                 220

 ctg aag ggc tac gtg tcc gag tac agc tgc cgc gag ctg cac ttc acc      720
 Leu Lys Gly Tyr Val Ser Glu Tyr Ser Cys Arg Glu Leu His Phe Thr
 225                 230                 235                 240

 cgc tac gtg acc gat ggg ccg tgc cgc agc gcc aag ccg gtc acc gag      768
 Arg Tyr Val Thr Asp Gly Pro Cys Arg Ser Ala Lys Pro Val Thr Glu
                 245                 250                 255

 ctg gtg tgc tcc ggc cag tgc ggc ccg gcg cgc ctg ctg ccc aac gcc      816
 Leu Val Cys Ser Gly Gln Cys Gly Pro Ala Arg Leu Leu Pro Asn Ala
             260                 265                 270

 atc ggc cgc ggc aag tgg tgg cga cct agt ggg ccc gac ttc cgc tgc      864
 Ile Gly Arg Gly Lys Trp Trp Arg Pro Ser Gly Pro Asp Phe Arg Cys
         275                 280                 285

 atc ccc gac cgc tac cgc gcg cag cgc gtg cag ctg ctg tgt ccc ggt      912
 Ile Pro Asp Arg Tyr Arg Ala Gln Arg Val Gln Leu Leu Cys Pro Gly
     290                 295                 300

 ggt gag gcg ccg cgc gcg cgc aag gtg cgc ctg gtg gcc tcg tgc aag      960
 Gly Glu Ala Pro Arg Ala Arg Lys Val Arg Leu Val Ala Ser Cys Lys
 305                 310                 315                 320

 tgc aag cgc ctc acc cgc ttc cac aac cag tcg gag ctc aag gac ttc     1008
 Cys Lys Arg Leu Thr Arg Phe His Asn Gln Ser Glu Leu Lys Asp Phe
                 325                 330                 335

 ggg acc gag gcc gct cgg ccg cag aag ggc cgg aag ccg cgg ccc cgc     1056
 Gly Thr Glu Ala Ala Arg Pro Gln Lys Gly Arg Lys Pro Arg Pro Arg
             340                 345                 350

 gcc cgg agc gcc aaa gcc aac cag gcc gag ctg gag aac gcc tac tag     1104
 Ala Arg Ser Ala Lys Ala Asn Gln Ala Glu Leu Glu Asn Ala Tyr 
         355                 360                 365





      <210> 731
      <211> 867
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (1)..(867)

      <400> 731
  atg ctg tgg cat ctg ttg tcg cag gta tat tgg ata aat gct gta tcc      48
  Met Leu Trp His Leu Leu Ser Gln Val Tyr Trp Ile Asn Ala Val Ser
    1               5                  10                  15

 aat gct cag gtg aga ggt gat agc tat gaa agc ggc tgt tta gga aga       96
 Asn Ala Gln Val Arg Gly Asp Ser Tyr Glu Ser Gly Cys Leu Gly Arg
              20                  25                  30

 aca ggt gct cga gtt tgg ctt ttc att ggt ttc atg ttg atg ttt ggg      144
 Thr Gly Ala Arg Val Trp Leu Phe Ile Gly Phe Met Leu Met Phe Gly
          35                  40                  45

 tca ctt att gct tcc atg tgg att ctt ttt ggt gca tat gtt acc caa      192
 Ser Leu Ile Ala Ser Met Trp Ile Leu Phe Gly Ala Tyr Val Thr Gln
      50                  55                  60

 agc tgg agt gca gtg gtg caa cca cag ctc act gca cct tca aat gct      240
 Ser Trp Ser Ala Val Val Gln Pro Gln Leu Thr Ala Pro Ser Asn Ala
  65                  70                  75                  80

 gga gct cag gca atc ctc tta cct ccg ctt tcc aag cag ctg gga cca      288
 Gly Ala Gln Ala Ile Leu Leu Pro Pro Leu Ser Lys Gln Leu Gly Pro
                  85                  90                  95

 cag aag aag ctc ttc tgt ctc cga ttt cct gaa cgg tct aag gtg aca      336
 Gln Lys Lys Leu Phe Cys Leu Arg Phe Pro Glu Arg Ser Lys Val Thr
             100                 105                 110

 gac ttc aga aag gcc aag gag gtg gct gct ggg agc ctg agt agg ggc      384
 Asp Phe Arg Lys Ala Lys Glu Val Ala Ala Gly Ser Leu Ser Arg Gly
         115                 120                 125

 agc gga cag tat ccc cct aca aca gca act atg gcc cag aaa gca agg      432
 Ser Gly Gln Tyr Pro Pro Thr Thr Ala Thr Met Ala Gln Lys Ala Arg
     130                 135                 140

 cca tgg gag aca gga gac gag act gga gac cgc tct ttt gtc tgc ttc      480
 Pro Trp Glu Thr Gly Asp Glu Thr Gly Asp Arg Ser Phe Val Cys Phe
 145                 150                 155                 160

 ttg tta ttg ggc cat gag aaa acg cag ctg gac ccg gct ctt tcc agg      528
 Leu Leu Leu Gly His Glu Lys Thr Gln Leu Asp Pro Ala Leu Ser Arg
                 165                 170                 175

 aac agg atc caa gca aag caa aca cga att cat gtg ggt acc ttt gtg      576
 Asn Arg Ile Gln Ala Lys Gln Thr Arg Ile His Val Gly Thr Phe Val
             180                 185                 190

 gat gag ggc aag aac aca gac agc cta ggg gcg gtg gag cat gtt cag      624
 Asp Glu Gly Lys Asn Thr Asp Ser Leu Gly Ala Val Glu His Val Gln
         195                 200                 205

 aaa gga cgc ggt ggt ctg gaa tat gtc tgg gtc acg tgg cgc ttc ctg      672
 Lys Gly Arg Gly Gly Leu Glu Tyr Val Trp Val Thr Trp Arg Phe Leu
     210                 215                 220

 tgg ctc act gcc tct gac ttt tca atc aac ttt gtg gct aaa gca cca      720
 Trp Leu Thr Ala Ser Asp Phe Ser Ile Asn Phe Val Ala Lys Ala Pro
 225                 230                 235                 240

 tgc act gtg ctt tgc atg gtc cgg act gtc tgg ttt gtc agc gac tca      768
 Cys Thr Val Leu Cys Met Val Arg Thr Val Trp Phe Val Ser Asp Ser
                 245                 250                 255

 ggg gct ttt cca gat gcg gga ctt tca gtg ctg aaa ctg gga aag ccc      816
 Gly Ala Phe Pro Asp Ala Gly Leu Ser Val Leu Lys Leu Gly Lys Pro
             260                 265                 270

 agg gta aac cag gat gag tca gcg gcc ctg cct cgt gct ctg gat aag      864
 Arg Val Asn Gln Asp Glu Ser Ala Ala Leu Pro Arg Ala Leu Asp Lys
         275                 280                 285

 taa                                                                  867
 






      <210> 732
      <211> 883
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (44)..(883)

      <400> 732
 cataaaaatc catgcttcgg gatttgacaa actcttggaa agc  atg ttc tgc atc      55
                                                  Met Phe Cys Ile
                                                    1

 ctg ctg gta gtg gaa gca ttt tcc ctg caa aaa gtt gtc aag atg ctg      103
 Leu Leu Val Val Glu Ala Phe Ser Leu Gln Lys Val Val Lys Met Leu
   5                  10                  15                  20

 gaa gaa gtg gta gct ggt tgg cga gag gtc aga aag gtc gat gtt gag      151
 Glu Glu Val Val Ala Gly Trp Arg Glu Val Arg Lys Val Asp Val Glu
                  25                  30                  35

 tta ttt gcc aac ttc ccg tgt aat tgt aag agg atc agc ttt gaa gat      199
 Leu Phe Ala Asn Phe Pro Cys Asn Cys Lys Arg Ile Ser Phe Glu Asp
              40                  45                  50

 tgc tct caa ttg gtt gtt gta aat ttc cga tgg tca gcc act atg ctc      247
 Cys Ser Gln Leu Val Val Val Asn Phe Arg Trp Ser Ala Thr Met Leu
          55                  60                  65

 ctc atc ttc aag gct ctc atc tcc ttt gca aag ctt ttt gaa cca cca      295
 Leu Ile Phe Lys Ala Leu Ile Ser Phe Ala Lys Leu Phe Glu Pro Pro
      70                  75                  80

 ctg tac tgt ctg ata act tta ata aac tac cat ctt ctt aaa ggc tct      343
 Leu Tyr Cys Leu Ile Thr Leu Ile Asn Tyr His Leu Leu Lys Gly Ser
  85                  90                  95                 100

 ctg gag cac agg act tca cct ggg ctc cgg cat caa cca gta tta agt      391
 Leu Glu His Arg Thr Ser Pro Gly Leu Arg His Gln Pro Val Leu Ser
                 105                 110                 115

 tta tcc tta gca ggt tca gtg gcc tct gag ttt cct gct aag gtg ctg      439
 Leu Ser Leu Ala Gly Ser Val Ala Ser Glu Phe Pro Ala Lys Val Leu
             120                 125                 130

 aaa atg ttt gaa aac ttt cca ctg atc aca aaa ccc aca cca ctc gct      487
 Lys Met Phe Glu Asn Phe Pro Leu Ile Thr Lys Pro Thr Pro Leu Ala
         135                 140                 145

 ggt gat atg ccc acg aat ccc aag gct tta gtc aca caa aga aaa cag      535
 Gly Asp Met Pro Thr Asn Pro Lys Ala Leu Val Thr Gln Arg Lys Gln
     150                 155                 160

 ccg ttc ttc cgc gct ttc ata aca tgt aac cat gcc ttt tac agg cag      583
 Pro Phe Phe Arg Ala Phe Ile Thr Cys Asn His Ala Phe Tyr Arg Gln
 165                 170                 175                 180

 ccc aaa tat cct cga aag agc acc ccc agg aga aac aag ctt ggc cac      631
 Pro Lys Tyr Pro Arg Lys Ser Thr Pro Arg Arg Asn Lys Leu Gly His
                 185                 190                 195

 tat gtc atc atc aag ttt ctg ctg acc act gag tct ccc atg aag aag      679
 Tyr Val Ile Ile Lys Phe Leu Leu Thr Thr Glu Ser Pro Met Lys Lys
             200                 205                 210

 aca gaa gac aac agc aca cct gtg ttc att gtg gat gtt aaa gcc aac      727
 Thr Glu Asp Asn Ser Thr Pro Val Phe Ile Val Asp Val Lys Ala Asn
         215                 220                 225

 aag cac cag atc aaa cag gct gtg aaa aag ctc tgt gac att gat gtg      775
 Lys His Gln Ile Lys Gln Ala Val Lys Lys Leu Cys Asp Ile Asp Val
     230                 235                 240

 gcc aag gtc aac acc ctg gtt agg act gat aga gag aag aag gca cat      823
 Ala Lys Val Asn Thr Leu Val Arg Thr Asp Arg Glu Lys Lys Ala His
 245                 250                 255                 260

 att ctt ctg ggt cct gat tat gat gct ttg gat gtt gcc aac aaa att      871
 Ile Leu Leu Gly Pro Asp Tyr Asp Ala Leu Asp Val Ala Asn Lys Ile
                 265                 270                 275

 ggg atc atc taa                                                      883
 Gly Ile Ile 






      <210> 733
      <211> 2052
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (1)..(2052)

      <400> 733
  atg gta tgg tgg ggc ctg tgg gct gtg ctg ctc cct gga gtg ggg gga      48
  Met Val Trp Trp Gly Leu Trp Ala Val Leu Leu Pro Gly Val Gly Gly
    1               5                  10                  15

 act cag cgg cgg ggc cag acc ttc aca gac cct cct tat gtc cac gga       96
 Thr Gln Arg Arg Gly Gln Thr Phe Thr Asp Pro Pro Tyr Val His Gly
              20                  25                  30

 ggg tgg att gag gtc agc act gca aag aaa gaa gac ata aac ctg agt      144
 Gly Trp Ile Glu Val Ser Thr Ala Lys Lys Glu Asp Ile Asn Leu Ser
          35                  40                  45

 gtt aga aag cta ctc aac aga cat aat att gtg ttt ggt gat tac aca      192
 Val Arg Lys Leu Leu Asn Arg His Asn Ile Val Phe Gly Asp Tyr Thr
      50                  55                  60

 tgg act gag ttt gat gaa cct ttt ttg acc aga aat gtg cag tct gtg      240
 Trp Thr Glu Phe Asp Glu Pro Phe Leu Thr Arg Asn Val Gln Ser Val
  65                  70                  75                  80

 tct att att gac aca gaa tta aag gtt aaa gac tca cag ccc atc gat      288
 Ser Ile Ile Asp Thr Glu Leu Lys Val Lys Asp Ser Gln Pro Ile Asp
                  85                  90                  95

 ttg agt gca tgc act gtt gca ctt cac att ttc cag ctg aat gaa gat      336
 Leu Ser Ala Cys Thr Val Ala Leu His Ile Phe Gln Leu Asn Glu Asp
             100                 105                 110

 ggc ccc agc agt gaa aat ctg gag gaa gag aca gaa aac ata att gca      384
 Gly Pro Ser Ser Glu Asn Leu Glu Glu Glu Thr Glu Asn Ile Ile Ala
         115                 120                 125

 gca aat cac tgg gtt cta cct gca gtg tgt ggg gaa aca ggt gga ttt      432
 Ala Asn His Trp Val Leu Pro Ala Val Cys Gly Glu Thr Gly Gly Phe
     130                 135                 140

 gga tgg gct ctg gca ggc caa gcc cag ggc ttc att cag tca gtg tgt      480
 Gly Trp Ala Leu Ala Gly Gln Ala Gln Gly Phe Ile Gln Ser Val Cys
 145                 150                 155                 160

 ggg gaa aca ggt gga ttt gga tgg gct ctg gca ggc caa gcc cag ggc      528
 Gly Glu Thr Gly Gly Phe Gly Trp Ala Leu Ala Gly Gln Ala Gln Gly
                 165                 170                 175

 ttc atg cag tca gtg tgt ggg gaa aca ggt gga ttt gga tgg gct ctg      576
 Phe Met Gln Ser Val Cys Gly Glu Thr Gly Gly Phe Gly Trp Ala Leu
             180                 185                 190

 gca ggc caa gcc cag ggc ttc att cag tca gtg tgt ggg gaa aca ggt      624
 Ala Gly Gln Ala Gln Gly Phe Ile Gln Ser Val Cys Gly Glu Thr Gly
         195                 200                 205

 gga ttt gga tgg gct ctg gca ggc caa gcc cag ggc ttc att cag tca      672
 Gly Phe Gly Trp Ala Leu Ala Gly Gln Ala Gln Gly Phe Ile Gln Ser
     210                 215                 220

 gtg tgt ggg gaa aca ggt gga ttt gga tgg gct ctg gca ggc caa gcc      720
 Val Cys Gly Glu Thr Gly Gly Phe Gly Trp Ala Leu Ala Gly Gln Ala
 225                 230                 235                 240

 cag ggc ttc att cag tca gtg tgt ggg gaa aca ggt gga ttt gga tgg      768
 Gln Gly Phe Ile Gln Ser Val Cys Gly Glu Thr Gly Gly Phe Gly Trp
                 245                 250                 255

 gct ctg gca ggc caa gcc cag ggc ttc att cag tca gtg tgt ggg gaa      816
 Ala Leu Ala Gly Gln Ala Gln Gly Phe Ile Gln Ser Val Cys Gly Glu
             260                 265                 270

 aca ggt gga ttt gga tgg gct ctg gca ggc caa gcc cag ggc ttc att      864
 Thr Gly Gly Phe Gly Trp Ala Leu Ala Gly Gln Ala Gln Gly Phe Ile
         275                 280                 285

 cag tca gtg tgt ggg gaa aca ggt gga ttt gga tgg gct ctg gca ggc      912
 Gln Ser Val Cys Gly Glu Thr Gly Gly Phe Gly Trp Ala Leu Ala Gly
     290                 295                 300

 caa gcc cac ggc ttc att cag tca gtg tgt ggg gaa aca ggt gga ttt      960
 Gln Ala His Gly Phe Ile Gln Ser Val Cys Gly Glu Thr Gly Gly Phe
 305                 310                 315                 320

 gga tgg gct ctg gca ggc caa gcc cag ggc ttc att cag tca gcc aag     1008
 Gly Trp Ala Leu Ala Gly Gln Ala Gln Gly Phe Ile Gln Ser Ala Lys
                 325                 330                 335

 cct agg gct tca ttc agt cag tgt gtg ggg aaa cag gtg gat ttg gat     1056
 Pro Arg Ala Ser Phe Ser Gln Cys Val Gly Lys Gln Val Asp Leu Asp
             340                 345                 350

 ggg ctc tgg cag gcc aac ccc agg gct tca ttc att cag tgt gtg ggg     1104
 Gly Leu Trp Gln Ala Asn Pro Arg Ala Ser Phe Ile Gln Cys Val Gly
         355                 360                 365

 aaa cag gtg gat ttg gat ggg ctc tgg cag gcc aag ccc cag ggc tta     1152
 Lys Gln Val Asp Leu Asp Gly Leu Trp Gln Ala Lys Pro Gln Gly Leu
     370                 375                 380

 att cag tta gtg tgt ggg gaa aca ggt gga ttt gga tgg gct ctg gca     1200
 Ile Gln Leu Val Cys Gly Glu Thr Gly Gly Phe Gly Trp Ala Leu Ala
 385                 390                 395                 400

 ggc caa gcc cag ggc ttc att cag tta gtg tgt ggg gaa aca ggt gga     1248
 Gly Gln Ala Gln Gly Phe Ile Gln Leu Val Cys Gly Glu Thr Gly Gly
                 405                 410                 415

 ttg gat ggg ctc tgg cag gcc aag ccc agg gct tca tgc agt cag tgt     1296
 Leu Asp Gly Leu Trp Gln Ala Lys Pro Arg Ala Ser Cys Ser Gln Cys
             420                 425                 430

 gtg ggg aaa cag gtg gat ttg gat ggg ctc tgg cag gcc aag ccc agg     1344
 Val Gly Lys Gln Val Asp Leu Asp Gly Leu Trp Gln Ala Lys Pro Arg
         435                 440                 445

 gct tca tgc agt cag tgt gtg ggg aaa cag gtg gat ttg gat ggg ctc     1392
 Ala Ser Cys Ser Gln Cys Val Gly Lys Gln Val Asp Leu Asp Gly Leu
     450                 455                 460

 tgg cag gcc aag ccc agg gct tca ttc agt cag tgt gtg ggg aaa cag     1440
 Trp Gln Ala Lys Pro Arg Ala Ser Phe Ser Gln Cys Val Gly Lys Gln
 465                 470                 475                 480

 gtg gat ttg gat ggg ctc tgg cag gcc aag ccc agg gct tca tgc agt     1488
 Val Asp Leu Asp Gly Leu Trp Gln Ala Lys Pro Arg Ala Ser Cys Ser
                 485                 490                 495

 cag tgt gtg ggg aaa cag gtg gat ttg gat ggg ctc tgg cag gcc aag     1536
 Gln Cys Val Gly Lys Gln Val Asp Leu Asp Gly Leu Trp Gln Ala Lys
             500                 505                 510

 ccc agg gct tca tgc agt cag tgt gtg ggg aaa cag gtg gat ttg gat     1584
 Pro Arg Ala Ser Cys Ser Gln Cys Val Gly Lys Gln Val Asp Leu Asp
         515                 520                 525

 ggg ctc tgg cag gcc aag ccc agg gct tca ttc agt cag tgt gtg ggg     1632
 Gly Leu Trp Gln Ala Lys Pro Arg Ala Ser Phe Ser Gln Cys Val Gly
     530                 535                 540

 aaa cag gtg gat ttg gat ggg ctc tgg cag gcc aag ccc agg gct tca     1680
 Lys Gln Val Asp Leu Asp Gly Leu Trp Gln Ala Lys Pro Arg Ala Ser
 545                 550                 555                 560

 ttc agt cag tgt gtg ggg aaa cag gtg gat ttg gat ggg ctc tgg cag     1728
 Phe Ser Gln Cys Val Gly Lys Gln Val Asp Leu Asp Gly Leu Trp Gln
                 565                 570                 575

 gcc aag ccc agg gct tca tgc agt cag tgt gtg ggg aaa cag gtg gat     1776
 Ala Lys Pro Arg Ala Ser Cys Ser Gln Cys Val Gly Lys Gln Val Asp
             580                 585                 590

 ttg gat ggg ctc tgg cag gcc aag ccc agg gcc ttc atg cag tca gtg     1824
 Leu Asp Gly Leu Trp Gln Ala Lys Pro Arg Ala Phe Met Gln Ser Val
         595                 600                 605

 tgt ggg gaa aca ggt gga ttt gga tgg gct ctg gca ggc caa gcc cag     1872
 Cys Gly Glu Thr Gly Gly Phe Gly Trp Ala Leu Ala Gly Gln Ala Gln
     610                 615                 620

 ggc ttc att cag tca gtg tgt ggg gaa aca ggt gga ttt gga tgg gct     1920
 Gly Phe Ile Gln Ser Val Cys Gly Glu Thr Gly Gly Phe Gly Trp Ala
 625                 630                 635                 640

 ctg gca ggc caa gcc cag ggc ttc att cag tgt gtg ggg aaa cag gtg     1968
 Leu Ala Gly Gln Ala Gln Gly Phe Ile Gln Cys Val Gly Lys Gln Val
                 645                 650                 655

 gat ttg gat ggg ctc tgg cag gcc aag ccc agg gct tca ttc agt cag     2016
 Asp Leu Asp Gly Leu Trp Gln Ala Lys Pro Arg Ala Ser Phe Ser Gln
             660                 665                 670

 tgt gtg ggg aaa cag gtg gat ttg gat ggg ctc tag                     2052
 Cys Val Gly Lys Gln Val Asp Leu Asp Gly Leu 
         675                 680





      <210> 734
      <211> 2304
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (1)..(2304)

      <400> 734
  atg gag aac tgg act ggc agg ccc tgg ctg tat ctg ctg ctg ctt ctg      48
  Met Glu Asn Trp Thr Gly Arg Pro Trp Leu Tyr Leu Leu Leu Leu Leu
    1               5                  10                  15

 tcc ctc cct cag ctc tgc ttg gat cag gag cac ccg ggc gcc tgg ctg       96
 Ser Leu Pro Gln Leu Cys Leu Asp Gln Glu His Pro Gly Ala Trp Leu
              20                  25                  30

 ccc ctg ctg agc aac ggc ccc cat gcc agc tcc ctc tgg agc ctc ttt      144
 Pro Leu Leu Ser Asn Gly Pro His Ala Ser Ser Leu Trp Ser Leu Phe
          35                  40                  45

 gct ccc agt agc cct att cca aga tgt tct ggg gag agt gaa cag cta      192
 Ala Pro Ser Ser Pro Ile Pro Arg Cys Ser Gly Glu Ser Glu Gln Leu
      50                  55                  60

 aga gcc tgc agc caa gcg ccc tgc ccc cct gag cag cca gac ccc cgg      240
 Arg Ala Cys Ser Gln Ala Pro Cys Pro Pro Glu Gln Pro Asp Pro Arg
  65                  70                  75                  80

 gcc ctg cag tgc gca gcc ttt aac tcc cag gaa ttc atg ggc cag ctg      288
 Ala Leu Gln Cys Ala Ala Phe Asn Ser Gln Glu Phe Met Gly Gln Leu
                  85                  90                  95

 tat cag tgg gag ccc ttc act gaa gtc cag ggc tcc cag cgc tgt gaa      336
 Tyr Gln Trp Glu Pro Phe Thr Glu Val Gln Gly Ser Gln Arg Cys Glu
             100                 105                 110

 ctg aac tgc cgg ccc cgt ggc ttc cgc ttc tat gtc cgt cac act gaa      384
 Leu Asn Cys Arg Pro Arg Gly Phe Arg Phe Tyr Val Arg His Thr Glu
         115                 120                 125

 aag gtc cag gat ggg acc ctg tgt cag cct gga gcc cct gac atc tgt      432
 Lys Val Gln Asp Gly Thr Leu Cys Gln Pro Gly Ala Pro Asp Ile Cys
     130                 135                 140

 gtg gct gga cgc tgt ctg agc ccc ggc tgt gat ggg atc ctt ggc tct      480
 Val Ala Gly Arg Cys Leu Ser Pro Gly Cys Asp Gly Ile Leu Gly Ser
 145                 150                 155                 160

 ggc agg cgt cct gat ggc tgt gga gtc tgt ggg ggt gat gat tct acc      528
 Gly Arg Arg Pro Asp Gly Cys Gly Val Cys Gly Gly Asp Asp Ser Thr
                 165                 170                 175

 tgt cgc ctt gtt tcg ggg aac ctc act gac cga ggg ggc ccc ctg ggc      576
 Cys Arg Leu Val Ser Gly Asn Leu Thr Asp Arg Gly Gly Pro Leu Gly
             180                 185                 190

 tat cag aag atc ttg tgg att cca gcg gga gcc ttg cgg ctc cag att      624
 Tyr Gln Lys Ile Leu Trp Ile Pro Ala Gly Ala Leu Arg Leu Gln Ile
         195                 200                 205

 gcc cag ctc cgg cct agc tcc aac tac ctg gca ctt cgt ggc cct ggg      672
 Ala Gln Leu Arg Pro Ser Ser Asn Tyr Leu Ala Leu Arg Gly Pro Gly
     210                 215                 220

 ggc cgg tcc atc atc aat ggg aac tgg gct gtg gat ccc cct ggg tcc      720
 Gly Arg Ser Ile Ile Asn Gly Asn Trp Ala Val Asp Pro Pro Gly Ser
 225                 230                 235                 240

 tac agg gcc ggc ggg acc gtc ttt cga tat aac cgt cct ccc agg gag      768
 Tyr Arg Ala Gly Gly Thr Val Phe Arg Tyr Asn Arg Pro Pro Arg Glu
                 245                 250                 255

 gag ggc aaa ggg gag agt ctg tcg gct gaa ggc ccc acc acc cag cct      816
 Glu Gly Lys Gly Glu Ser Leu Ser Ala Glu Gly Pro Thr Thr Gln Pro
             260                 265                 270

 gtg gat gtc tat atg atc ttt cag gag gaa aac cca ggc gtt ttt tat      864
 Val Asp Val Tyr Met Ile Phe Gln Glu Glu Asn Pro Gly Val Phe Tyr
         275                 280                 285

 cag tat gtc atc tct tca cct cct cca atc ctt gag aac ccc acc cca      912
 Gln Tyr Val Ile Ser Ser Pro Pro Pro Ile Leu Glu Asn Pro Thr Pro
     290                 295                 300

 gag ccc cct gtc ccc cag ctt cag ccg gag att ctg agg gtg gag ccc      960
 Glu Pro Pro Val Pro Gln Leu Gln Pro Glu Ile Leu Arg Val Glu Pro
 305                 310                 315                 320

 cca ctt gct ccg gca ccc cgc cca gcc cgg acc cca ggc acc ctc cag     1008
 Pro Leu Ala Pro Ala Pro Arg Pro Ala Arg Thr Pro Gly Thr Leu Gln
                 325                 330                 335

 cgt cag gtg cgg atc ccc cag atg ccc gcc ccg ccc cat ccc agg aca     1056
 Arg Gln Val Arg Ile Pro Gln Met Pro Ala Pro Pro His Pro Arg Thr
             340                 345                 350

 ccc ctg ggg tct cca gct gcg tac tgg aaa cga gtg gga cac tct gca     1104
 Pro Leu Gly Ser Pro Ala Ala Tyr Trp Lys Arg Val Gly His Ser Ala
         355                 360                 365

 tgc tca gcg tcc tgc ggg aaa ggt gtc tgg cgc ccc att ttc ctc tgc     1152
 Cys Ser Ala Ser Cys Gly Lys Gly Val Trp Arg Pro Ile Phe Leu Cys
     370                 375                 380

 atc tcc cgt gag tcg gga gag gaa ctg gat gaa cgc agc tgt gcc gcg     1200
 Ile Ser Arg Glu Ser Gly Glu Glu Leu Asp Glu Arg Ser Cys Ala Ala
 385                 390                 395                 400

 ggt gcc agg ccc cca gcc tcc cct gaa ccc tgc cac ggc acc cca tgc     1248
 Gly Ala Arg Pro Pro Ala Ser Pro Glu Pro Cys His Gly Thr Pro Cys
                 405                 410                 415

 ccc cca tac tgg gag gct ggc gag tgg aca tcc tgc agc cgc tcc tgt     1296
 Pro Pro Tyr Trp Glu Ala Gly Glu Trp Thr Ser Cys Ser Arg Ser Cys
             420                 425                 430

 ggc ccc ggc acc cag cac cgc cag ctg cag tgc cgg cag gaa ttt ggg     1344
 Gly Pro Gly Thr Gln His Arg Gln Leu Gln Cys Arg Gln Glu Phe Gly
         435                 440                 445

 ggg ggt ggc tcc tcg gtg ccc ccg gag cgc tgt gga cat ctc ccc cgg     1392
 Gly Gly Gly Ser Ser Val Pro Pro Glu Arg Cys Gly His Leu Pro Arg
     450                 455                 460

 ccc aac atc acc cag tct tgc cag ctg cgc ctc tgt ggc cat tgg gaa     1440
 Pro Asn Ile Thr Gln Ser Cys Gln Leu Arg Leu Cys Gly His Trp Glu
 465                 470                 475                 480

 gtt ggc tct cct tgg agc cag tgc tcc gtg cgg tgc ggc cgg ggc cag     1488
 Val Gly Ser Pro Trp Ser Gln Cys Ser Val Arg Cys Gly Arg Gly Gln
                 485                 490                 495

 aga agc cgg cag gtt cgc tgt gtt ggg aac aat ggt gat gaa gtg agc     1536
 Arg Ser Arg Gln Val Arg Cys Val Gly Asn Asn Gly Asp Glu Val Ser
             500                 505                 510

 gag cag gag tgt gcg tca ggc ccc ccg cag ccc ccc agc aga gag gcc     1584
 Glu Gln Glu Cys Ala Ser Gly Pro Pro Gln Pro Pro Ser Arg Glu Ala
         515                 520                 525

 tgt gac atg ggg ccc tgt act act gcc tgg ttc cac agc gac tgg agc     1632
 Cys Asp Met Gly Pro Cys Thr Thr Ala Trp Phe His Ser Asp Trp Ser
     530                 535                 540

 tcc aag tgc tca gcc gag tgt ggg acg gga atc cag cgg cgc tct gtg     1680
 Ser Lys Cys Ser Ala Glu Cys Gly Thr Gly Ile Gln Arg Arg Ser Val
 545                 550                 555                 560

 gtc tgc ctt ggg agt ggg gca gcc ctc ggg cca ggc cag ggg gaa gca     1728
 Val Cys Leu Gly Ser Gly Ala Ala Leu Gly Pro Gly Gln Gly Glu Ala
                 565                 570                 575

 gga gca gga act ggg cag agc tgt cca aca gga agc cgg ccc cct gac     1776
 Gly Ala Gly Thr Gly Gln Ser Cys Pro Thr Gly Ser Arg Pro Pro Asp
             580                 585                 590

 atg cgc gcc tgc agc ctg ggg ccc tgt gag aga act tgg cgc tgg tac     1824
 Met Arg Ala Cys Ser Leu Gly Pro Cys Glu Arg Thr Trp Arg Trp Tyr
         595                 600                 605

 aca ggg ccc tgg ggt gag tgc tcc tcc gaa tgt ggc tct ggc aca cag     1872
 Thr Gly Pro Trp Gly Glu Cys Ser Ser Glu Cys Gly Ser Gly Thr Gln
     610                 615                 620

 cgt aga gac atc atc tgt gta tcc aaa ctg ggg acg gag ttc aac gtg     1920
 Arg Arg Asp Ile Ile Cys Val Ser Lys Leu Gly Thr Glu Phe Asn Val
 625                 630                 635                 640

 act tct ccg agc aac tgt tct cac ctc ccc agg ccc cct gcc ctg cag     1968
 Thr Ser Pro Ser Asn Cys Ser His Leu Pro Arg Pro Pro Ala Leu Gln
                 645                 650                 655

 ccc tgt caa ggg cag gcc tgc cag gac cga tgg ttt tcc acg ccc tgg     2016
 Pro Cys Gln Gly Gln Ala Cys Gln Asp Arg Trp Phe Ser Thr Pro Trp
             660                 665                 670

 agc cca tgt tct cgc tcc tgc caa ggg gga acg cag aca cgg gag gtc     2064
 Ser Pro Cys Ser Arg Ser Cys Gln Gly Gly Thr Gln Thr Arg Glu Val
         675                 680                 685

 cag tgc ctg agc acc aac cag acc ctc agc acc cga tgc cct cct caa     2112
 Gln Cys Leu Ser Thr Asn Gln Thr Leu Ser Thr Arg Cys Pro Pro Gln
     690                 695                 700

 ctg cgg ccc tcc agg aag cgc ccc tgt aac agc caa ccc tgc agc cag     2160
 Leu Arg Pro Ser Arg Lys Arg Pro Cys Asn Ser Gln Pro Cys Ser Gln
 705                 710                 715                 720

 cgc cct gat gat caa tgc aag gac agc tct cca cat tgc ccc ctg gtg     2208
 Arg Pro Asp Asp Gln Cys Lys Asp Ser Ser Pro His Cys Pro Leu Val
                 725                 730                 735

 gta cag gcc cgg ctc tgc gtc tac ccc tac tac aca gcc acc tgt tgc     2256
 Val Gln Ala Arg Leu Cys Val Tyr Pro Tyr Tyr Thr Ala Thr Cys Cys
             740                 745                 750

 cgc tct tgc gca cat gtc ctg gag cgg tct ccc cag gat ccc tcc tga     2304
 Arg Ser Cys Ala His Val Leu Glu Arg Ser Pro Gln Asp Pro Ser 
         755                 760                 765





      <210> 735
      <211> 870
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (690)..(870)

      <400> 735
 atgggactgc agccacccca cgtgagtgat ggcaccatgg agactgttgt acttgaccat     60

 gctgagctgg ggcaggacgc cagtgcagct ggtcaccacc ccactggtgc ggatcagctg    120

 gttcagatgc agctgcctgc ggaggcagag ggtgcatcag aagccgaatc acgaccgagt    180

 cacccagcac tgagctcgga cctgccatcc tcacctgccc tcagctcacc tcagcgagcg    240

 cagctcctcc accagaggca ggtgggagat gcggacatgg atgtggttgg tgatgcggtc    300

 gtacttgggg tacatggcca gtaccacctc cagggcagcc tcatcaaaga tctgcagcag    360

 ctccgccggt gcctcaggca ggaaactcct tcccagcttc ccagtccctc gggcaggcag    420

 acaactggac ctaccataca ggagcccacg gcgcatgcgg cccaggcccc ggccagcctc    480

 ccggtcacgc tgccgcatgg cccgctttgc tgcctccctc tgactggccg tcagctcctc    540

 tacgtcctca tcatccagag ccagtccctc ggcctcatag gcgtccagct ctgggatggc    600

 gcgggacggc aggatgccct gcacagtact ctcacacatg ctaaggctga aaaggcacaa    660

 aaggagcatc tccacgaggc tcctgggca  ttc aca caa ttc cgc tac tga cgt     713
                                  Met Pro Arg Ser Leu Val Glu Met
                                    1               5

 tat cta cca gat cgc agc tgg aaa tgc aga aac cct gga tca agc tgt      761
 Leu Leu Leu Cys Leu Phe Ser Leu Ser Met Cys Glu Ser Thr Val Gln
      10                  15                  20

 gct caa agg caa gaa tgc cat cga ttc atc tgc tcc cag ctc cca aag      809
 Gly Ile Leu Pro Ser Arg Ala Ile Pro Glu Leu Asp Ala Tyr Glu Ala
  25                  30                  35                  40

 cca ggc cac cag gca cac aat ggg ctc tct gca aaa cta tct gct gag      857
 Glu Gly Leu Ala Leu Asp Asp Glu Asp Val Glu Glu Leu Thr Ala Ser
                  45                  50                  55

 tcc agg gcc ttg a                                                    870
 Gln Arg Glu Ala Ala Lys Arg Ala Met Arg Gln Arg Asp Arg Glu Ala 
              60                  65                  70





      <210> 736
      <211> 714
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (636)..(714)

      <400> 736
 atgaggatgc aaaggcataa gaaagacaca aagaactctg gggattcaga gggaaagggt     60

 gggaaggggg attccagcct cgtagctgat gtgcatgagg ttctcgtcca tgttccacgg    120

 gttcttggga gtgaccggga taggaatccc gtgctgcttt gcgtattcca tcaggtcatt    180

 acggcccttg aaccggttgt agaactcggg catcctccag ggagcagtgc cctttatctg    240

 ggggaccagc gagtaccagg gcctggcgag aaaggtgccc aggaggtagc ggtcctcata    300

 cagtgtgctg gactggatgg ccggccagat gaactcttcc acaaactccc tgatgacatc    360

 ctcaatgaac acctttttgg ccccaagttt cagtgccttc ttcctggctt cctcgaagtc    420

 ttccttctgg ccagtgttgg ccaggtaggc aatgacatca tagccttgtt ccttcaccca    480

 cacgaggatg caggagacgc ccccaggttg gtaaaccgac tgaacaagag ggaagaggca    540

 agttccgtgg gtcagggcat caccgaacag gaatccccgg agacacgccc aggagccgag    600

 gagggcagag gtgctccagt cgggccgctg agcca   tcc ttc ttg gct ggg ctc     653
                                          Met Ala Gln Arg Pro Asp
                                            1               5

 tga gaa gaa agg gga gtg ggc act gtc cgc tgg aag tga gct ggc tgc      701
 Trp Ser Thr Ser Ala Leu Leu Gly Ser Trp Ala Cys Leu Arg Gly Phe
              10                  15                  20

 cta tga ccc cta a                                                    714
 Leu Phe Gly Asp Ala Leu Thr His Gly Thr Cys Leu Phe Pro Leu Val 
          25                  30                  35





      <210> 737
      <211> 507
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (1)..(507)

      <400> 737
  atg ctt gct ctg gcc acg tgg gcc ttg gcc atc atg gca ggg cat ggt      48
  Met Leu Ala Leu Ala Thr Trp Ala Leu Ala Ile Met Ala Gly His Gly
    1               5                  10                  15

 ggg tgg ctg gga att gga gac act gtg gag ttt atg act gtc acc tac       96
 Gly Trp Leu Gly Ile Gly Asp Thr Val Glu Phe Met Thr Val Thr Tyr
              20                  25                  30

 att aca gtt cag gac atg cct gct cgt ggt gcc cag gac atg cct gct      144
 Ile Thr Val Gln Asp Met Pro Ala Arg Gly Ala Gln Asp Met Pro Ala
          35                  40                  45

 cgt ggt gcc cag gac atg cct gct cgt ggt gcc cag gac atg cct gct      192
 Arg Gly Ala Gln Asp Met Pro Ala Arg Gly Ala Gln Asp Met Pro Ala
      50                  55                  60

 cgt ggt gcc cag gac atg cct gct cgt ggt gcc cag gac atg cct gct      240
 Arg Gly Ala Gln Asp Met Pro Ala Arg Gly Ala Gln Asp Met Pro Ala
  65                  70                  75                  80

 cgt ggt gcc cag gac atg cct gct cgt ggt gcc cag gac atg cct gct      288
 Arg Gly Ala Gln Asp Met Pro Ala Arg Gly Ala Gln Asp Met Pro Ala
                  85                  90                  95

 cgt ggt gcc cag gac atg cct gct cgt ggt gcc cag gac atg cct gct      336
 Arg Gly Ala Gln Asp Met Pro Ala Arg Gly Ala Gln Asp Met Pro Ala
             100                 105                 110

 cgt ggt gcc cag gac atg cct gct cgt ggt gcc cag gac atg cct gct      384
 Arg Gly Ala Gln Asp Met Pro Ala Arg Gly Ala Gln Asp Met Pro Ala
         115                 120                 125

 cgt ggt gcc cag gac atg cct gct cgt ggt gcc cag gac atg cct gct      432
 Arg Gly Ala Gln Asp Met Pro Ala Arg Gly Ala Gln Asp Met Pro Ala
     130                 135                 140

 cgt ggt gcc cag gac atg cct gct cgt ggt gcc cag gac atg cct gct      480
 Arg Gly Ala Gln Asp Met Pro Ala Arg Gly Ala Gln Asp Met Pro Ala
 145                 150                 155                 160

 cgt ggt gcc gtg tct ctc ttc tgc taa                                  507
 Arg Gly Ala Val Ser Leu Phe Cys 
                 165





      <210> 738
      <211> 1545
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (1)..(1545)

      <400> 738
  atg ctt atc act acc ctg tac gtc aat gct cag gca ggg ctt gct acc      48
  Met Leu Ile Thr Thr Leu Tyr Val Asn Ala Gln Ala Gly Leu Ala Thr
    1               5                  10                  15

 gtg aag gaa agg aag gtc acc tgg cta gtg gta aga gac agt cag aac       96
 Val Lys Glu Arg Lys Val Thr Trp Leu Val Val Arg Asp Ser Gln Asn
              20                  25                  30

 tcg aac cca ggt ctg ggc cac tcg gtt gcc ttc ctg tct cta aca gaa      144
 Ser Asn Pro Gly Leu Gly His Ser Val Ala Phe Leu Ser Leu Thr Glu
          35                  40                  45

 gat cca gaa ttt att tgg gag aac aaa gct ccc aaa att gag ttt gaa      192
 Asp Pro Glu Phe Ile Trp Glu Asn Lys Ala Pro Lys Ile Glu Phe Glu
      50                  55                  60

 caa aat aag cac gga ctg aat cag gta cac gca cct gcc ggg gac gca      240
 Gln Asn Lys His Gly Leu Asn Gln Val His Ala Pro Ala Gly Asp Ala
  65                  70                  75                  80

 ctg acc gag gtg cgg acg gcg gta cca gga cag ctt cag acc ccc aca      288
 Leu Thr Glu Val Arg Thr Ala Val Pro Gly Gln Leu Gln Thr Pro Thr
                  85                  90                  95

 ccc tct cct gct gct gtg tct cca act gat gct gaa agt aaa agc cgc      336
 Pro Ser Pro Ala Ala Val Ser Pro Thr Asp Ala Glu Ser Lys Ser Arg
             100                 105                 110

 cac tca ctg gcc ggt tac ctg ccc agc act cca cag agc ttg ttt ttt      384
 His Ser Leu Ala Gly Tyr Leu Pro Ser Thr Pro Gln Ser Leu Phe Phe
         115                 120                 125

 gtg acc ttc atg aca gct atc atc act acg aag agc aaa aca ggc cac      432
 Val Thr Phe Met Thr Ala Ile Ile Thr Thr Lys Ser Lys Thr Gly His
     130                 135                 140

 ttg ccc acc ttg aca gag ctg gtc tgt gcc gat cca ttc ctg tca aag      480
 Leu Pro Thr Leu Thr Glu Leu Val Cys Ala Asp Pro Phe Leu Ser Lys
 145                 150                 155                 160

 tcc atc caa ggt gtg tca gac aac cca gat gag cca gga gag aca gca      528
 Ser Ile Gln Gly Val Ser Asp Asn Pro Asp Glu Pro Gly Glu Thr Ala
                 165                 170                 175

 gag gtg ctc cct tgg gcg caa ctg ggg gca gat gca ggg aat gga tgg      576
 Glu Val Leu Pro Trp Ala Gln Leu Gly Ala Asp Ala Gly Asn Gly Trp
             180                 185                 190

 acg ttg ggc tac cct ctt gct tcc ctt tac cca tca aca acc aag aag      624
 Thr Leu Gly Tyr Pro Leu Ala Ser Leu Tyr Pro Ser Thr Thr Lys Lys
         195                 200                 205

 cac aca ctg agc cac ttc ctg aat acc tac tgt gtg cca ggg tgg aga      672
 His Thr Leu Ser His Phe Leu Asn Thr Tyr Cys Val Pro Gly Trp Arg
     210                 215                 220

 ttc ttt ggg gga atc gga ctc tgc ctt gtc ctc aag gag ctg gtg gag      720
 Phe Phe Gly Gly Ile Gly Leu Cys Leu Val Leu Lys Glu Leu Val Glu
 225                 230                 235                 240

 ctg ctg gct cct tac cca gag tta gct tca atc ctg gat gca agc tgc      768
 Leu Leu Ala Pro Tyr Pro Glu Leu Ala Ser Ile Leu Asp Ala Ser Cys
                 245                 250                 255

 ccg ctg tgc ata gtc aca gtc agc tgg ggc tgt act gga agc atg gtg      816
 Pro Leu Cys Ile Val Thr Val Ser Trp Gly Cys Thr Gly Ser Met Val
             260                 265                 270

 gcg gca aag gtg ctg ccc cag ggt ggt ttc aca ttc atg aat tca ttt      864
 Ala Ala Lys Val Leu Pro Gln Gly Gly Phe Thr Phe Met Asn Ser Phe
         275                 280                 285

 gag atc tat tac tct ctt gtg aag gag aaa gcc cag ggc tca tca tcc      912
 Glu Ile Tyr Tyr Ser Leu Val Lys Glu Lys Ala Gln Gly Ser Ser Ser
     290                 295                 300

 ctg ttc tac agg tac tat cat cca tct att ggc aag aat gca aaa aga      960
 Leu Phe Tyr Arg Tyr Tyr His Pro Ser Ile Gly Lys Asn Ala Lys Arg
 305                 310                 315                 320

 atg tcc agt tct ggc cat gat gtg gga aga ggg ctt ttg cat cca ttg     1008
 Met Ser Ser Ser Gly His Asp Val Gly Arg Gly Leu Leu His Pro Leu
                 325                 330                 335

 ctg ggg act gag aat tgc cgc ccc aac ttt ctc atc tgt aaa gtg gaa     1056
 Leu Gly Thr Glu Asn Cys Arg Pro Asn Phe Leu Ile Cys Lys Val Glu
             340                 345                 350

 gaa ggg aag gac cac tac atg atc tct gta atg cag aac ggt gac act     1104
 Glu Gly Lys Asp His Tyr Met Ile Ser Val Met Gln Asn Gly Asp Thr
         355                 360                 365

 acc cag ttc ttc att caa caa gta ttt att gaa tat atc tac tct gtg     1152
 Thr Gln Phe Phe Ile Gln Gln Val Phe Ile Glu Tyr Ile Tyr Ser Val
     370                 375                 380

 ccc aag att ctg cca ggt gaa gat gat gtg gct gac tct cct cgc ttc     1200
 Pro Lys Ile Leu Pro Gly Glu Asp Asp Val Ala Asp Ser Pro Arg Phe
 385                 390                 395                 400

 cct gaa cgt cat tct acc tgc cgg tcc cca cag cct tct cgc cat gtg     1248
 Pro Glu Arg His Ser Thr Cys Arg Ser Pro Gln Pro Ser Arg His Val
                 405                 410                 415

 gtc tct tcc ttg ctg tct ctc cat agc ctg ctg acc aat gct cct gcc     1296
 Val Ser Ser Leu Leu Ser Leu His Ser Leu Leu Thr Asn Ala Pro Ala
             420                 425                 430

 cag tcc ccc tgt gat cac agc tcc tcg cca gca aca gaa caa agc tgg     1344
 Gln Ser Pro Cys Asp His Ser Ser Ser Pro Ala Thr Glu Gln Ser Trp
         435                 440                 445

 atg gag aat gac ttt gat gag ttg aca gaa gta ggc ttc aga agg tcg     1392
 Met Glu Asn Asp Phe Asp Glu Leu Thr Glu Val Gly Phe Arg Arg Ser
     450                 455                 460

 gta ata aca aac ttc ttc aag cta aag gag tat gtt cta acc cat cac     1440
 Val Ile Thr Asn Phe Phe Lys Leu Lys Glu Tyr Val Leu Thr His His
 465                 470                 475                 480

 aag gaa gct aaa aac ctt gaa aaa atg tta gac gaa tgg cta act aga     1488
 Lys Glu Ala Lys Asn Leu Glu Lys Met Leu Asp Glu Trp Leu Thr Arg
                 485                 490                 495

 atc aac agt gta gag aag acc tta aat gac ctg atg gag ctg aaa aac     1536
 Ile Asn Ser Val Glu Lys Thr Leu Asn Asp Leu Met Glu Leu Lys Asn
             500                 505                 510

 atg gca tga                                                         1545
 Met Ala 






      <210> 739
      <211> 747
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (1)..(747)

      <400> 739
  atg ccc gtg ggg ggc ctg ttg ccg ctc ttc agc agc ccc gcg ggc ggc      48
  Met Pro Val Gly Gly Leu Leu Pro Leu Phe Ser Ser Pro Ala Gly Gly
    1               5                  10                  15

 gtc ctg ggc ggg ggg ctc ggc ggc ggc ggt ggc agg aag ggg tcg ggc       96
 Val Leu Gly Gly Gly Leu Gly Gly Gly Gly Gly Arg Lys Gly Ser Gly
              20                  25                  30

 ccc gcc gcc ctc cgc ctg acg gag aag ttc gtg ctg ctg ctg gta ttc      144
 Pro Ala Ala Leu Arg Leu Thr Glu Lys Phe Val Leu Leu Leu Val Phe
          35                  40                  45

 agc gcc ttc atc acg ctc tgc ttc ggg gcg atc ttc ttc ctg cca gac      192
 Ser Ala Phe Ile Thr Leu Cys Phe Gly Ala Ile Phe Phe Leu Pro Asp
      50                  55                  60

 tcc tcc aag ctg ctc agc ggg gtc ctg ttc cac tcc agc ccc gcc ttg      240
 Ser Ser Lys Leu Leu Ser Gly Val Leu Phe His Ser Ser Pro Ala Leu
  65                  70                  75                  80

 cag ccg gcc gcc gac cac aag ccc ggg ccc ggg gcg cgc gcc gag gac      288
 Gln Pro Ala Ala Asp His Lys Pro Gly Pro Gly Ala Arg Ala Glu Asp
                  85                  90                  95

 gcg gcc gag ggg cga gcc cgg cgc cgc gag gag ggg gca ccc ggg gac      336
 Ala Ala Glu Gly Arg Ala Arg Arg Arg Glu Glu Gly Ala Pro Gly Asp
             100                 105                 110

 ccg gag gcc gcc ctg gag gac aac ttg gcc agg atc cgc gaa aac cac      384
 Pro Glu Ala Ala Leu Glu Asp Asn Leu Ala Arg Ile Arg Glu Asn His
         115                 120                 125

 gag cgg gct ctc agg gaa gcc aag gag acc ctg cag aag ctg ccc gag      432
 Glu Arg Ala Leu Arg Glu Ala Lys Glu Thr Leu Gln Lys Leu Pro Glu
     130                 135                 140

 gag atc caa aga gac atc cta ctg gag aag aag aag gtg gcc cag gac      480
 Glu Ile Gln Arg Asp Ile Leu Leu Glu Lys Lys Lys Val Ala Gln Asp
 145                 150                 155                 160

 cag ctg cgt gac aag gcg ccg ttc aga ggc ctg ccc ccg gtg gac ttc      528
 Gln Leu Arg Asp Lys Ala Pro Phe Arg Gly Leu Pro Pro Val Asp Phe
                 165                 170                 175

 gtg ccc cca atc ggg gtg gag agc cgg gag ccc gcc gac gcc gcc atc      576
 Val Pro Pro Ile Gly Val Glu Ser Arg Glu Pro Ala Asp Ala Ala Ile
             180                 185                 190

 cgc gag aaa agg gca aag atc aaa gag gta ata cgc aaa cct cat tct      624
 Arg Glu Lys Arg Ala Lys Ile Lys Glu Val Ile Arg Lys Pro His Ser
         195                 200                 205

 ctg gcc gct aca cgg tta atc gcc cca cca gta aca gcg acg gca ctg      672
 Leu Ala Ala Thr Arg Leu Ile Ala Pro Pro Val Thr Ala Thr Ala Leu
     210                 215                 220

 atc agc ccc ctg gta agg att ggg gac gtg gct tta aac cct aaa tgg      720
 Ile Ser Pro Leu Val Arg Ile Gly Asp Val Ala Leu Asn Pro Lys Trp
 225                 230                 235                 240

 cag gcc aac tgc cag aag ccc cac tga                                  747
 Gln Ala Asn Cys Gln Lys Pro His 
                 245





      <210> 740
      <211> 1083
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (1)..(1083)

      <400> 740
  atg gca ttc ctg ggc aag gcc tgg cag ctc tgg aag gct ctc gtt gag      48
  Met Ala Phe Leu Gly Lys Ala Trp Gln Leu Trp Lys Ala Leu Val Glu
    1               5                  10                  15

 ttg gct ctg tta ccc atg aga gga aac tct cag ctg tca cat gtt gat       96
 Leu Ala Leu Leu Pro Met Arg Gly Asn Ser Gln Leu Ser His Val Asp
              20                  25                  30

 tgt tca gat gag cag aga agt ggg cac aga aag agt tgg gca cag gac      144
 Cys Ser Asp Glu Gln Arg Ser Gly His Arg Lys Ser Trp Ala Gln Asp
          35                  40                  45

 tgg tta agt gtg gat ggg ggt caa ctt gga aga aag cgt agc ggg gat      192
 Trp Leu Ser Val Asp Gly Gly Gln Leu Gly Arg Lys Arg Ser Gly Asp
      50                  55                  60

 act gca caa agg aag cca gcc cag gct cct tat cac att tct tct tca      240
 Thr Ala Gln Arg Lys Pro Ala Gln Ala Pro Tyr His Ile Ser Ser Ser
  65                  70                  75                  80

 caa ggt ggg tgc cag acc tac atg gac atc gtc att gtc ctg gat ggc      288
 Gln Gly Gly Cys Gln Thr Tyr Met Asp Ile Val Ile Val Leu Asp Gly
                  85                  90                  95

 tcc aac agc atc tac ccc tgg gtg gag gtt cag cac ttc ctc atc aac      336
 Ser Asn Ser Ile Tyr Pro Trp Val Glu Val Gln His Phe Leu Ile Asn
             100                 105                 110

 atc ctg aaa aag ttt tac att ggc cca ggg cag atc cag gtt gga gtt      384
 Ile Leu Lys Lys Phe Tyr Ile Gly Pro Gly Gln Ile Gln Val Gly Val
         115                 120                 125

 gtg cag tat ggc gaa gat gtg gtg cat gag ttt cac ctc aac gac tac      432
 Val Gln Tyr Gly Glu Asp Val Val His Glu Phe His Leu Asn Asp Tyr
     130                 135                 140

 agg tct gta aaa gat gtg gtg gaa gct gcc agc cac att gag cag aga      480
 Arg Ser Val Lys Asp Val Val Glu Ala Ala Ser His Ile Glu Gln Arg
 145                 150                 155                 160

 gga gga aca gag acc cgg acg gca ttt ggc att gaa ttt gca cga acc      528
 Gly Gly Thr Glu Thr Arg Thr Ala Phe Gly Ile Glu Phe Ala Arg Thr
                 165                 170                 175

 tca tgg tct aaa gga ggg ccg gcc aca ggg aca cca aaa gcc agt ggt      576
 Ser Trp Ser Lys Gly Gly Pro Ala Thr Gly Thr Pro Lys Ala Ser Gly
             180                 185                 190

 gat ttg gga gcc agt ttt tca tgc ttt gta gcc caa tgg cct gtt aca      624
 Asp Leu Gly Ala Ser Phe Ser Cys Phe Val Ala Gln Trp Pro Val Thr
         195                 200                 205

 aga gcc tct ctg cca att gac ggt cga ggt gcc agc cct gct gtc tcc      672
 Arg Ala Ser Leu Pro Ile Asp Gly Arg Gly Ala Ser Pro Ala Val Ser
     210                 215                 220

 tgg gct gga ttg cct gat agc tca gag gct ttc cag aag ggt gga agg      720
 Trp Ala Gly Leu Pro Asp Ser Ser Glu Ala Phe Gln Lys Gly Gly Arg
 225                 230                 235                 240

 aaa gga gcc aag aag gtg atg att gtc atc aca gat ggg gag tcc cac      768
 Lys Gly Ala Lys Lys Val Met Ile Val Ile Thr Asp Gly Glu Ser His
                 245                 250                 255

 gac agc cca gac ctg gag aag gtg atc cag caa agc gaa aga gac aac      816
 Asp Ser Pro Asp Leu Glu Lys Val Ile Gln Gln Ser Glu Arg Asp Asn
             260                 265                 270

 gta aca aga tat gcg gtg gcc gtc ctg ggc tac tac aac cgc agg ggg      864
 Val Thr Arg Tyr Ala Val Ala Val Leu Gly Tyr Tyr Asn Arg Arg Gly
         275                 280                 285

 atc aat cca gaa act ttt cta aat gaa atc aaa tac atc gcc agt gac      912
 Ile Asn Pro Glu Thr Phe Leu Asn Glu Ile Lys Tyr Ile Ala Ser Asp
     290                 295                 300

 cct gat gac aag cac ttc ttc aat gtc act gat gag gct gcc ttg aag      960
 Pro Asp Asp Lys His Phe Phe Asn Val Thr Asp Glu Ala Ala Leu Lys
 305                 310                 315                 320

 gac att gtc gat gcc ctg ggg gac aga atc ttc agc ctg gaa ggt gag     1008
 Asp Ile Val Asp Ala Leu Gly Asp Arg Ile Phe Ser Leu Glu Gly Glu
                 325                 330                 335

 gtc act tac cct gca cgt gat gac cta aca gga cca gtg ctc agt tct     1056
 Val Thr Tyr Pro Ala Arg Asp Asp Leu Thr Gly Pro Val Leu Ser Ser
             340                 345                 350

 gtt atg aag cag gtc aag ttc agc tga                                 1083
 Val Met Lys Gln Val Lys Phe Ser 
         355                 360





      <210> 741
      <211> 957
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (1)..(957)

      <400> 741
  atg aaa cac ctg tgg ttc ttc ctc ctg ctg gtg gca gct ccc aga ttg      48
  Met Lys His Leu Trp Phe Phe Leu Leu Leu Val Ala Ala Pro Arg Leu
    1               5                  10                  15

 gtc ctg tcc cag gtg cag ctg cag gag tcg ggc cca gga ctg gtg aag       96
 Val Leu Ser Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys
              20                  25                  30

 cct tcg gac acc ctg tcc ctc acc tgc gct gtc tct ggt tac tcc atc      144
 Pro Ser Asp Thr Leu Ser Leu Thr Cys Ala Val Ser Gly Tyr Ser Ile
          35                  40                  45

 agc agt agt aac tgg tgg ggc tgg atc cgg cag ccc cca ggg aag gga      192
 Ser Ser Ser Asn Trp Trp Gly Trp Ile Arg Gln Pro Pro Gly Lys Gly
      50                  55                  60

 ctg gag tgg att ggg tac atc tat tat agt ggg agc acc tac tac aac      240
 Leu Glu Trp Ile Gly Tyr Ile Tyr Tyr Ser Gly Ser Thr Tyr Tyr Asn
  65                  70                  75                  80

 ccg tcc ctc aag agt cga gtc acc atg tca gta gac acg tcc aag aac      288
 Pro Ser Leu Lys Ser Arg Val Thr Met Ser Val Asp Thr Ser Lys Asn
                  85                  90                  95

 cag ttc tcc ctg aag ctg agc tct gtg acc gcc gtg gac acg gcc gtg      336
 Gln Phe Ser Leu Lys Leu Ser Ser Val Thr Ala Val Asp Thr Ala Val
             100                 105                 110

 tat tac tgt gcg aga aac aca gtg agg gga gcg tgg agc tgt ttc aat      384
 Tyr Tyr Cys Ala Arg Asn Thr Val Arg Gly Ala Trp Ser Cys Phe Asn
         115                 120                 125

 cgc agc agg atg gga atg tgt ctt ctt tct ggg gac ttt tta agc aca      432
 Arg Ser Arg Met Gly Met Cys Leu Leu Ser Gly Asp Phe Leu Ser Thr
     130                 135                 140

 gct ctt atg ttc ctg aga ttt gag gtt tat aaa ggt gtg tca gtc acc      480
 Ala Leu Met Phe Leu Arg Phe Glu Val Tyr Lys Gly Val Ser Val Thr
 145                 150                 155                 160

 cac aga gtg gac ctg cac aac atc atc caa caa cca caa ctc tcc tca      528
 His Arg Val Asp Leu His Asn Ile Ile Gln Gln Pro Gln Leu Ser Ser
                 165                 170                 175

 gaa gaa gcc cct aga cca cag cac ctc aac atg tac tgg acc tgg agg      576
 Glu Glu Ala Pro Arg Pro Gln His Leu Asn Met Tyr Trp Thr Trp Arg
             180                 185                 190

 atc ctc ttc ttg gtg gca gca gca aca ggt gtc cac tca cag gtg cag      624
 Ile Leu Phe Leu Val Ala Ala Ala Thr Gly Val His Ser Gln Val Gln
         195                 200                 205

 ctg gtg cag tct ggg cct gag gtg aag aag cct gga gcc tca ttg aag      672
 Leu Val Gln Ser Gly Pro Glu Val Lys Lys Pro Gly Ala Ser Leu Lys
     210                 215                 220

 gtt tcc tgc aag gct tct gga tac acc ttc aca agc tat gct atc agc      720
 Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Tyr Ala Ile Ser
 225                 230                 235                 240

 tgg gcc cat gga caa ggg ctt gag gaa atg gga tgg atc aac acc aac      768
 Trp Ala His Gly Gln Gly Leu Glu Glu Met Gly Trp Ile Asn Thr Asn
                 245                 250                 255

 act ggg aac cta acg tat gcc cag ggc ttc aca gga cgg ttt gtc ttc      816
 Thr Gly Asn Leu Thr Tyr Ala Gln Gly Phe Thr Gly Arg Phe Val Phe
             260                 265                 270

 tcc atg gac acc tcc gtc agc atg gca tat ctt cat atc agc agc cta      864
 Ser Met Asp Thr Ser Val Ser Met Ala Tyr Leu His Ile Ser Ser Leu
         275                 280                 285

 aag gct gag gac acg tgc aag agg cac agt gtg gaa acc cac atc ctg      912
 Lys Ala Glu Asp Thr Cys Lys Arg His Ser Val Glu Thr His Ile Leu
     290                 295                 300

 aga gaa cca gaa atc ctg agg gag gag gca gct gtg ctg agc tga          957
 Arg Glu Pro Glu Ile Leu Arg Glu Glu Ala Ala Val Leu Ser 
 305                 310                 315





      <210> 742
      <211> 1443
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (969)..(1379)

      <400> 742
 atgctcttgc tttcccatgc aactgtaacg tttggagatt cagacaacga atgctcagaa     60

 ggccagaacc cctgtctctg cagcagcaag ttaggaagga acattcggcc ggccccaaca    120

 cctaccccaa tagctgaagt tttccacgca tgggaggaca atgcttaccc tgctgaggag    180

 cgtgcctgga tctcaattac ttcgattgtc ccagtggccc tgctgatacc acatgaagca    240

 gaactgtcca gtcaagccac ggagttgggg ccaataataa gctgttgttt gaagtcacta    300

 agctttcaga tggcttgtta tgcagcaaga gagaaacaaa atagcctcga agggtatctg    360

 ggccacgacg gcatttcaga acattcacac agatacgaca ccagctgctg gcaaaagaga    420

 agcccccaca ctgagcctca cgtaccaaag gccaaagtca aacctatcct gccccagagc    480

 tccatgtacc ctcctccaac ccctcatggg tccctagtgt ccatgaggac ccaaaagggc    540

 agtgggcgca gccacgactc accgtggaaa cacagcaagt actcctctcg ctgccctgcg    600

 ctgttcacct gcacgattga gacagggaag ctgttggaag aggcggcaaa cacagcagag    660

 ccaatcttcc ctgtaccacc ccttctgtcc ctgctgattg gccaagcccg gcccacctcc    720

 agggcggggc tcctccggct cctcctcacc tgctttggct gtatttgcga gttcggaagc    780

 accaacggca ccatgaatag atacatcccc gtcgggaagg cacagctcaa attcttccac    840

 cggcctctgt ccagcttggt gcaaagagga agggcagaaa gaaaaacaaa agaacaggaa    900

 caagaacaag gggagaagag agagcgagag agacagcaag ggagagagag acagggtatt    960

 ccaagtca tca agg cct ctc ctg caa aac cac tgc cac tgc tgc tat ggt    1010
          Met Thr Trp Asn Thr Leu Ser Leu Ser Pro Leu Leu Ser Leu
            1               5                  10

 atg ctt ctg cat ttg gaa gga aac tgc aag ctt ctt caa gac ttt tct     1058
 Ser Leu Ser Leu Leu Pro Leu Phe Leu Phe Leu Phe Phe Cys Phe Ser
  15                  20                  25                  30

 gga act gag aac acc tgg cca aac cta aat ggt ttc aac tgt cac tga     1106
 Phe Cys Pro Ser Ser Leu His Gln Ala Gly Gln Arg Pro Val Glu Glu
                  35                  40                  45

 aat ctg cct ccg gct caa tgt cag cca gaa gtc tgt gct caa aaa tct     1154
 Phe Glu Leu Cys Leu Pro Asp Gly Asp Val Ser Ile His Gly Ala Val
              50                  55                  60

 ttc tgt caa tcc taa aga aca aag cgg aat cat cag tga ttc aac aca     1202
 Gly Ala Ser Glu Leu Ala Asn Thr Ala Lys Ala Gly Glu Glu Glu Pro
          65                  70                  75

 cag ggc tct ggt tgg gga gtg gga ggt agt cat caa ttt aaa tag ccg     1250
 Glu Glu Pro Arg Pro Gly Gly Gly Pro Gly Leu Ala Asn Gln Gln Gly
      80                  85                  90

 ttc tca gag ttc tgt gaa aag ata tgc aac att ctg gaa aag gga aaa     1298
 Gln Lys Gly Trp Tyr Arg Glu Asp Trp Leu Cys Cys Val Cys Arg Leu
  95                 100                 105                 110

 cta tgg aga cag caa aaa gat cag tgg ctg cca gga gtt gag gtt gta     1346
 Phe Gln Gln Leu Pro Cys Leu Asn Arg Ala Gly Glu Gln Arg Arg Ala
                 115                 120                 125

 caa tct cgt cgt tgg cgc cag aag cct cat cga gttgtttg gacaagtaga     1397
 Ala Arg Gly Val Leu Ala Val Phe Pro Arg 
             130                 135

 agttttggtt gttgagttca gcgttgtcct cggtcagctg gtttag                  1443




      <210> 743
      <211> 462
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (1)..(462)

      <400> 743
  atg act ttg ctg tct ctg ctg ggt cgc atc atg cgc tac ttc ttg ctg      48
  Met Thr Leu Leu Ser Leu Leu Gly Arg Ile Met Arg Tyr Phe Leu Leu
    1               5                  10                  15

 aga ccc gag acg ctt ttc ctg ctg tgc atc agc ttg gct cta tgg agt       96
 Arg Pro Glu Thr Leu Phe Leu Leu Cys Ile Ser Leu Ala Leu Trp Ser
              20                  25                  30

 tac ttc ttc cac acc gac gag gtg aag acc atc gtg aag tcc agc cgg      144
 Tyr Phe Phe His Thr Asp Glu Val Lys Thr Ile Val Lys Ser Ser Arg
          35                  40                  45

 gac gcc gtg aag atg gtg aag ggc aag gta gcc gag atc atg cag aac      192
 Asp Ala Val Lys Met Val Lys Gly Lys Val Ala Glu Ile Met Gln Asn
      50                  55                  60

 gat cga ctc ggg ggg ctt gat gtg ctc gag gcc gag ttt tcc aag acc      240
 Asp Arg Leu Gly Gly Leu Asp Val Leu Glu Ala Glu Phe Ser Lys Thr
  65                  70                  75                  80

 tgg gag ttc aag aac cac aac gtg gcg gtg tac tcc atc cag ggc cgg      288
 Trp Glu Phe Lys Asn His Asn Val Ala Val Tyr Ser Ile Gln Gly Arg
                  85                  90                  95

 aga gac cac atg gag gac cgc ttc gaa gtt ctc acg gat ctg gcc aac      336
 Arg Asp His Met Glu Asp Arg Phe Glu Val Leu Thr Asp Leu Ala Asn
             100                 105                 110

 aag acg cac ccg tcc atc ttc ggg atc ttc gac ggg cac ggg gga gag      384
 Lys Thr His Pro Ser Ile Phe Gly Ile Phe Asp Gly His Gly Gly Glu
         115                 120                 125

 gca aac agg cta tat ctg cag agc gag ctc att gag ggt gaa gga agc      432
 Ala Asn Arg Leu Tyr Leu Gln Ser Glu Leu Ile Glu Gly Glu Gly Ser
     130                 135                 140

 tgt gac tcc ttc cca tcg cct tca ctc tag                              462
 Cys Asp Ser Phe Pro Ser Pro Ser Leu 
 145                 150





      <210> 744
      <211> 557
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (105)..(557)

      <400> 744
 tttctccttc tgccttatgt ctcctcggtc gaattctttc ttctgagaca agaagtgagg     60

 ttgctgcaga tccatatgga tttgcagcag actggaaaca agac atg gac gtc cac     116
                                                  Met Asp Val His
                                                    1

 tct tac tac ttc aac att gta cta ttg ctt cta gcc agc atg ata aga      164
 Ser Tyr Tyr Phe Asn Ile Val Leu Leu Leu Leu Ala Ser Met Ile Arg
   5                  10                  15                  20

 aat gaa ggc act tgg gga aac tgc aca gat ctc tgg gtc cgc cta tct      212
 Asn Glu Gly Thr Trp Gly Asn Cys Thr Asp Leu Trp Val Arg Leu Ser
                  25                  30                  35

 ccc act gcc atc cct gca aag aga tat ccc ccg gat act cac atg ggc      260
 Pro Thr Ala Ile Pro Ala Lys Arg Tyr Pro Pro Asp Thr His Met Gly
              40                  45                  50

 tcg aga gtc ttg ctg agc cag gac ttg agt gcc tcg aag ttt tca atg      308
 Ser Arg Val Leu Leu Ser Gln Asp Leu Ser Ala Ser Lys Phe Ser Met
          55                  60                  65

 atc att tta gaa acc atc cac agc ggc cct aag gcc cgt cac act cct      356
 Ile Ile Leu Glu Thr Ile His Ser Gly Pro Lys Ala Arg His Thr Pro
      70                  75                  80

 ccg ccc gcc cag caa atc tac cca gac cgg aag cgc gac acg cgc tta      404
 Pro Pro Ala Gln Gln Ile Tyr Pro Asp Arg Lys Arg Asp Thr Arg Leu
  85                  90                  95                 100

 gac ccg agc ctt ctc tca gcc tcg gga cca ggt gct tgt tgg cta cgt      452
 Asp Pro Ser Leu Leu Ser Ala Ser Gly Pro Gly Ala Cys Trp Leu Arg
                 105                 110                 115

 cga aaa ggc aaa agt aaa gaa agc gaa ggc gaa ggg cag ctc aat ggg      500
 Arg Lys Gly Lys Ser Lys Glu Ser Glu Gly Glu Gly Gln Leu Asn Gly
             120                 125                 130

 aac gat tca ggg ggt ctt ccc ggc tcc cag cac ccc caa gaa gat ggc      548
 Asn Asp Ser Gly Gly Leu Pro Gly Ser Gln His Pro Gln Glu Asp Gly
         135                 140                 145

 tgc cgg taa                                                          557
 Cys Arg 
     150





      <210> 745
      <211> 705
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (1)..(705)

      <400> 745
  atg gag act gtg gtg att gtt gcc ata ggt gtg ctg gcc acc atc ttt      48
  Met Glu Thr Val Val Ile Val Ala Ile Gly Val Leu Ala Thr Ile Phe
    1               5                  10                  15

 ctg gct tcg ttt gca gcc ttg gtg ctg gtt tgc agg cag cgc tac tgc       96
 Leu Ala Ser Phe Ala Ala Leu Val Leu Val Cys Arg Gln Arg Tyr Cys
              20                  25                  30

 cgg ccg cga gac ctg ctg cag cgc tat gat tct aat gta act agg aaa      144
 Arg Pro Arg Asp Leu Leu Gln Arg Tyr Asp Ser Asn Val Thr Arg Lys
          35                  40                  45

 agg cag gga tat agg gat gga cca aag tgg ttc aca aga gtt att ctg      192
 Arg Gln Gly Tyr Arg Asp Gly Pro Lys Trp Phe Thr Arg Val Ile Leu
      50                  55                  60

 cag acc agg ccc att gtg gac ctc att ggt gcc atg gag acc cag tct      240
 Gln Thr Arg Pro Ile Val Asp Leu Ile Gly Ala Met Glu Thr Gln Ser
  65                  70                  75                  80

 gag ccc tct gag tta gaa ctg gac gat gtc gtt atc acc aac ccc cac      288
 Glu Pro Ser Glu Leu Glu Leu Asp Asp Val Val Ile Thr Asn Pro His
                  85                  90                  95

 att gag gcc att ctg gag aat gaa gac tgg atc gaa gat gcc tcc cat      336
 Ile Glu Ala Ile Leu Glu Asn Glu Asp Trp Ile Glu Asp Ala Ser His
             100                 105                 110

 cca ttc cct ggt ccc atg ttt gtg ggg cat tat gtg gag ggt act ggg      384
 Pro Phe Pro Gly Pro Met Phe Val Gly His Tyr Val Glu Gly Thr Gly
         115                 120                 125

 tca ggt gct gca gat att gaa acg gtt gaa aag aca gtt ata gtc agt      432
 Ser Gly Ala Ala Asp Ile Glu Thr Val Glu Lys Thr Val Ile Val Ser
     130                 135                 140

 atc aca gaa act gta aga gat cct tgt gta cag tgc agt agg cac atg      480
 Ile Thr Glu Thr Val Arg Asp Pro Cys Val Gln Cys Ser Arg His Met
 145                 150                 155                 160

 gag aag gca gtg tct agg ttt gcc tgg gtt ggg gag gtt gag ctg gat      528
 Glu Lys Ala Val Ser Arg Phe Ala Trp Val Gly Glu Val Glu Leu Asp
                 165                 170                 175

 ctc atg gaa gat atc aca gag gag ggg tct cat gtc cca ctg cat tgc      576
 Leu Met Glu Asp Ile Thr Glu Glu Gly Ser His Val Pro Leu His Cys
             180                 185                 190

 cat ctt gaa ggt aac cct ctc tta ttt ctc tgt ggg ata aag ggt agt      624
 His Leu Glu Gly Asn Pro Leu Leu Phe Leu Cys Gly Ile Lys Gly Ser
         195                 200                 205

 cga aaa gca cca ctg tgc gtg gat gga gta gaa cgg gac ctt aga aag      672
 Arg Lys Ala Pro Leu Cys Val Asp Gly Val Glu Arg Asp Leu Arg Lys
     210                 215                 220

 ggc act gac ctc tcg caa gag gcc ttt cct taa                          705
 Gly Thr Asp Leu Ser Gln Glu Ala Phe Pro 
 225                 230





      <210> 746
      <211> 531
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (1)..(531)

      <400> 746
  atg cgg ctc ctg cct cta gcc cca ggt cgg ctc cgg cgg ggc agc ccc      48
  Met Arg Leu Leu Pro Leu Ala Pro Gly Arg Leu Arg Arg Gly Ser Pro
    1               5                  10                  15

 cgc cac ctg ccc tcc tgc agc cca gcg ctg cta ctg ctg gtg ctg ggc       96
 Arg His Leu Pro Ser Cys Ser Pro Ala Leu Leu Leu Leu Val Leu Gly
              20                  25                  30

 ggc tgc ctg ggg gtc ttc ggg gtg gct gcg gga acc cgg agg ccc aac      144
 Gly Cys Leu Gly Val Phe Gly Val Ala Ala Gly Thr Arg Arg Pro Asn
          35                  40                  45

 gtg gtg ctg ctc ctc acg gac gac cag gac gaa gtg ctc ggc ggc atg      192
 Val Val Leu Leu Leu Thr Asp Asp Gln Asp Glu Val Leu Gly Gly Met
      50                  55                  60

 gta act ctt ctg ttt ctg ccc cgc ccc tct atc tct tgg gct gac tac      240
 Val Thr Leu Leu Phe Leu Pro Arg Pro Ser Ile Ser Trp Ala Asp Tyr
  65                  70                  75                  80

 ccg gtt tgt tgc tct ctt tcc cgg tcc cca cca ccc tcc tcc ccg aac      288
 Pro Val Cys Cys Ser Leu Ser Arg Ser Pro Pro Pro Ser Ser Pro Asn
                  85                  90                  95

 tgg ctg tct tat cct tgg gta ggt ttg gtt ttc cca cct gag gcc ctt      336
 Trp Leu Ser Tyr Pro Trp Val Gly Leu Val Phe Pro Pro Glu Ala Leu
             100                 105                 110

 tat gcc ggt gta agg gac tgc aat act ctt ttc ctt tct gga ttg agg      384
 Tyr Ala Gly Val Arg Asp Cys Asn Thr Leu Phe Leu Ser Gly Leu Arg
         115                 120                 125

 cac atg cgt aca gca cac aga gct tct agt ctg gac cgt act gct gtg      432
 His Met Arg Thr Ala His Arg Ala Ser Ser Leu Asp Arg Thr Ala Val
     130                 135                 140

 gag ttt acg tta ata tct caa gat aaa cat gtg gag acc agt gga gga      480
 Glu Phe Thr Leu Ile Ser Gln Asp Lys His Val Glu Thr Ser Gly Gly
 145                 150                 155                 160

 tgg gtt gaa cca atg agg atc agg tgc tgt cta aga gca ctc aag gcc      528
 Trp Val Glu Pro Met Arg Ile Arg Cys Cys Leu Arg Ala Leu Lys Ala
                 165                 170                 175

 tga                                                                  531
 






      <210> 747
      <211> 2223
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (1)..(2223)

      <400> 747
  atg gcg ttt cct cct gtg gca cag ctg cca gtg ggg ctg gcc gcc gtc      48
  Met Ala Phe Pro Pro Val Ala Gln Leu Pro Val Gly Leu Ala Ala Val
    1               5                  10                  15

 tgg gct ggt cct cta gac ttc tct ggc tcc cac gct ggc aaa tct ccc       96
 Trp Ala Gly Pro Leu Asp Phe Ser Gly Ser His Ala Gly Lys Ser Pro
              20                  25                  30

 cac cag cag cag ttt ttg gtg ttc cag cag cag ctg cat ccc ctc ctg      144
 His Gln Gln Gln Phe Leu Val Phe Gln Gln Gln Leu His Pro Leu Leu
          35                  40                  45

 aag gtc tgg ggc tcc act cga ggg ggc gga agt ctt agt tcc ttc att      192
 Lys Val Trp Gly Ser Thr Arg Gly Gly Gly Ser Leu Ser Ser Phe Ile
      50                  55                  60

 gtt gac tcc ctc tca gcc cta aag aag ctt gga gcc cct gaa caa gct      240
 Val Asp Ser Leu Ser Ala Leu Lys Lys Leu Gly Ala Pro Glu Gln Ala
  65                  70                  75                  80

 gca att ctg tgc ctg ggc ttt tct gac tgc aaa atg agg ata atc aca      288
 Ala Ile Leu Cys Leu Gly Phe Ser Asp Cys Lys Met Arg Ile Ile Thr
                  85                  90                  95

 gcc cct gcc tcc aaa gtg tcc cga gga tca aat gag ttg atg ata ctt      336
 Ala Pro Ala Ser Lys Val Ser Arg Gly Ser Asn Glu Leu Met Ile Leu
             100                 105                 110

 gca cgg cgc tcg gat cgt ggc tgg gga ctg ggc ttc ccc gga ggc cgc      384
 Ala Arg Arg Ser Asp Arg Gly Trp Gly Leu Gly Phe Pro Gly Gly Arg
         115                 120                 125

 acc tgg aag gaa tac gcc ccg gat aag gcc cgc gat gga aac gga acc      432
 Thr Trp Lys Glu Tyr Ala Pro Asp Lys Ala Arg Asp Gly Asn Gly Thr
     130                 135                 140

 cgg ctg gct cac tgc cag cgg cct ggt caa gaa ggc ggg ctc cgg agc      480
 Arg Leu Ala His Cys Gln Arg Pro Gly Gln Glu Gly Gly Leu Arg Ser
 145                 150                 155                 160

 ccg act gcc ggg gct gtg ccc gca gga aaa ggt gcc cga gag aac ctt      528
 Pro Thr Ala Gly Ala Val Pro Ala Gly Lys Gly Ala Arg Glu Asn Leu
                 165                 170                 175

 gac cct ctg gcc aga acc agg cag gct tgc aaa ctc act gag ttc cac      576
 Asp Pro Leu Ala Arg Thr Arg Gln Ala Cys Lys Leu Thr Glu Phe His
             180                 185                 190

 cag ttc aaa cac aag cat tca gcc aaa aca aat gga gaa ctg ata ggc      624
 Gln Phe Lys His Lys His Ser Ala Lys Thr Asn Gly Glu Leu Ile Gly
         195                 200                 205

 acg gag gta aaa ttg att aac cga atc ttg ccc tcc act ggc tta ctg      672
 Thr Glu Val Lys Leu Ile Asn Arg Ile Leu Pro Ser Thr Gly Leu Leu
     210                 215                 220

 tgc aac ggt aga gac tgg aag caa cag acg agg agc aca gct tcc aga      720
 Cys Asn Gly Arg Asp Trp Lys Gln Gln Thr Arg Ser Thr Ala Ser Arg
 225                 230                 235                 240

 gga gag aag ata ccc cca gca tcc atg aga aga gac ctc cgg gag aag      768
 Gly Glu Lys Ile Pro Pro Ala Ser Met Arg Arg Asp Leu Arg Glu Lys
                 245                 250                 255

 ctt gtg tgg gtg tgc cga cca ctg gcc cca gtt gag gtc cca gcc aac      816
 Leu Val Trp Val Cys Arg Pro Leu Ala Pro Val Glu Val Pro Ala Asn
             260                 265                 270

 atc agc tcc gac ttc cag cca tgc tca cca act tct cct gcc cac tcc      864
 Ile Ser Ser Asp Phe Gln Pro Cys Ser Pro Thr Ser Pro Ala His Ser
         275                 280                 285

 cta tca agg aaa agt ccc ata atg tat cca tca acc acc atg gct aat      912
 Leu Ser Arg Lys Ser Pro Ile Met Tyr Pro Ser Thr Thr Met Ala Asn
     290                 295                 300

 gca ccc ggt ctg gtg agc tgt acc ttc ttt ctg gca gtg aat ggt ctg      960
 Ala Pro Gly Leu Val Ser Cys Thr Phe Phe Leu Ala Val Asn Gly Leu
 305                 310                 315                 320

 tat tcc tct agt gat gat gtg atc gaa tta act cca tcg aat ttc aac     1008
 Tyr Ser Ser Ser Asp Asp Val Ile Glu Leu Thr Pro Ser Asn Phe Asn
                 325                 330                 335

 cga gaa gtt att cag agt gat agt ttg tgg ctt gta gaa ttc tat gct     1056
 Arg Glu Val Ile Gln Ser Asp Ser Leu Trp Leu Val Glu Phe Tyr Ala
             340                 345                 350

 cca tgg tgt ggt cac tgt caa aga tta aca cca gaa tgg aag aaa gca     1104
 Pro Trp Cys Gly His Cys Gln Arg Leu Thr Pro Glu Trp Lys Lys Ala
         355                 360                 365

 gca act gca tta aaa gat gtt gtc aaa gtt ggt gca gtt gat gca gat     1152
 Ala Thr Ala Leu Lys Asp Val Val Lys Val Gly Ala Val Asp Ala Asp
     370                 375                 380

 aag cat cat tcc cta gga ggt cag tat ggt gtt cag gga ttt cct acc     1200
 Lys His His Ser Leu Gly Gly Gln Tyr Gly Val Gln Gly Phe Pro Thr
 385                 390                 395                 400

 att aag att ttt gga tcc aac aaa aac aga cca gaa gat tac caa ggt     1248
 Ile Lys Ile Phe Gly Ser Asn Lys Asn Arg Pro Glu Asp Tyr Gln Gly
                 405                 410                 415

 ggc aga act ggt gaa gcc att gta gat gct gcg ctg agt gct ctg cgc     1296
 Gly Arg Thr Gly Glu Ala Ile Val Asp Ala Ala Leu Ser Ala Leu Arg
             420                 425                 430

 cag ctc gtg aag gat cgc ctc ggg gga cgg agc gga gga tac agt tct     1344
 Gln Leu Val Lys Asp Arg Leu Gly Gly Arg Ser Gly Gly Tyr Ser Ser
         435                 440                 445

 gga aaa caa ggc aga agt gat agt tca agt aag aag gat gtg att gag     1392
 Gly Lys Gln Gly Arg Ser Asp Ser Ser Ser Lys Lys Asp Val Ile Glu
     450                 455                 460

 ctg aca gac gac agc ttt gat aag aat gtt ctg gac agt gaa gat gtt     1440
 Leu Thr Asp Asp Ser Phe Asp Lys Asn Val Leu Asp Ser Glu Asp Val
 465                 470                 475                 480

 tgg atg gtt gag ttc tat gct cct tgg tgt gga cac tgc aaa aac cta     1488
 Trp Met Val Glu Phe Tyr Ala Pro Trp Cys Gly His Cys Lys Asn Leu
                 485                 490                 495

 gag cca gag tgg gct gcc gca gct tca gaa gta aaa gag cag acg aaa     1536
 Glu Pro Glu Trp Ala Ala Ala Ala Ser Glu Val Lys Glu Gln Thr Lys
             500                 505                 510

 gga aaa gtg aaa ctg gca gct gtg gat gct aca gtc aat cag gtt ctg     1584
 Gly Lys Val Lys Leu Ala Ala Val Asp Ala Thr Val Asn Gln Val Leu
         515                 520                 525

 gcc tcc cga tac ggg att aga gga ttt cct aca atc aag ata ttt cag     1632
 Ala Ser Arg Tyr Gly Ile Arg Gly Phe Pro Thr Ile Lys Ile Phe Gln
     530                 535                 540

 aaa ggc gag tct cct gtg gat tat gac ggt ggg cgg aca aga tcc gac     1680
 Lys Gly Glu Ser Pro Val Asp Tyr Asp Gly Gly Arg Thr Arg Ser Asp
 545                 550                 555                 560

 atc gtg tcc cgg gcc ctt gat ttg ttt tct gat aac gcc cca cct cct     1728
 Ile Val Ser Arg Ala Leu Asp Leu Phe Ser Asp Asn Ala Pro Pro Pro
                 565                 570                 575

 gag ctg ctt gag att atc aac gag gac att gcc aag agg acg tgt gag     1776
 Glu Leu Leu Glu Ile Ile Asn Glu Asp Ile Ala Lys Arg Thr Cys Glu
             580                 585                 590

 gag cac cag ctc tgt gtt gtg gct gtg ctg ccc cat atc ctt gat act     1824
 Glu His Gln Leu Cys Val Val Ala Val Leu Pro His Ile Leu Asp Thr
         595                 600                 605

 gga gct gca ggc aga aat tct tat ctg gaa gtt ctt ctg aag ttg gca     1872
 Gly Ala Ala Gly Arg Asn Ser Tyr Leu Glu Val Leu Leu Lys Leu Ala
     610                 615                 620

 gac aaa tac aaa aag aaa atg tgg ggg tgg ctg tgg aca gaa gct gga     1920
 Asp Lys Tyr Lys Lys Lys Met Trp Gly Trp Leu Trp Thr Glu Ala Gly
 625                 630                 635                 640

 gcc cag tct gaa ctt gag acc gcg ttg ggg att gga ggg ttt ggg tac     1968
 Ala Gln Ser Glu Leu Glu Thr Ala Leu Gly Ile Gly Gly Phe Gly Tyr
                 645                 650                 655

 ccc gcc atg gcc gcc atc aat gca cgc aag atg aaa ttt gct ctg cta     2016
 Pro Ala Met Ala Ala Ile Asn Ala Arg Lys Met Lys Phe Ala Leu Leu
             660                 665                 670

 aaa ggc tcc ttc agt gag caa ggc atc aac gag ttt ctc agg gag ctc     2064
 Lys Gly Ser Phe Ser Glu Gln Gly Ile Asn Glu Phe Leu Arg Glu Leu
         675                 680                 685

 tct ttt ggg cgt ggc tcc acg gca cct gta gga ggc ggg gct ttc cct     2112
 Ser Phe Gly Arg Gly Ser Thr Ala Pro Val Gly Gly Gly Ala Phe Pro
     690                 695                 700

 acc atc gtt gag aga gag cct tgg gac ggc agg gat ggc gag ctt ccc     2160
 Thr Ile Val Glu Arg Glu Pro Trp Asp Gly Arg Asp Gly Glu Leu Pro
 705                 710                 715                 720

 gtg gag gat gac att gac ctc agt gat gtg gag ctt gat gac tta ggg     2208
 Val Glu Asp Asp Ile Asp Leu Ser Asp Val Glu Leu Asp Asp Leu Gly
                 725                 730                 735

 aaa gat gag ttg tga                                                 2223
 Lys Asp Glu Leu 
             740





      <210> 748
      <211> 516
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (1)..(516)

      <400> 748
  atg gct tta acc cta gta gtg gtg gtg ggt tgg cag gag gcg tgt tca      48
  Met Ala Leu Thr Leu Val Val Val Val Gly Trp Gln Glu Ala Cys Ser
    1               5                  10                  15

 aat ttt gga aat aca ctg aag gta gag cag aga gga ttc atg ggc agg       96
 Asn Phe Gly Asn Thr Leu Lys Val Glu Gln Arg Gly Phe Met Gly Arg
              20                  25                  30

 ctt gat gat gaa tgc aga aga aag aga ggc att aat gag gac aaa gtg      144
 Leu Asp Asp Glu Cys Arg Arg Lys Arg Gly Ile Asn Glu Asp Lys Val
          35                  40                  45

 tgg acc ata gtg tct cat gac ttg cag atg cag acg cct gtg gtc ggc      192
 Trp Thr Ile Val Ser His Asp Leu Gln Met Gln Thr Pro Val Val Gly
      50                  55                  60

 tac aac cca gaa aaa tac tca gtg aca cag ctc gtt tac agc gcc tcc      240
 Tyr Asn Pro Glu Lys Tyr Ser Val Thr Gln Leu Val Tyr Ser Ala Ser
  65                  70                  75                  80

 atg gac cag ata agt gcc atc act gac agt gcc gag tac tgc gag cag      288
 Met Asp Gln Ile Ser Ala Ile Thr Asp Ser Ala Glu Tyr Cys Glu Gln
                  85                  90                  95

 tat gtc tcc tat ttc tgc aag atg tca aga ttg ttg aac acc cca gaa      336
 Tyr Val Ser Tyr Phe Cys Lys Met Ser Arg Leu Leu Asn Thr Pro Glu
             100                 105                 110

 gaa act ctt atg tct aag cct aac aca agt gac aca tcc agt gtt tca      384
 Glu Thr Leu Met Ser Lys Pro Asn Thr Ser Asp Thr Ser Ser Val Ser
         115                 120                 125

 ttc tta cct tat aaa ttt gct ttt gat aga gtt ctc cga gat cct gtt      432
 Phe Leu Pro Tyr Lys Phe Ala Phe Asp Arg Val Leu Arg Asp Pro Val
     130                 135                 140

 aaa acg aga aag atc aga aat cac cag ctt ggc aga gcc cga ctt ctc      480
 Lys Thr Arg Lys Ile Arg Asn His Gln Leu Gly Arg Ala Arg Leu Leu
 145                 150                 155                 160

 acc ttt ctg agc ctt cat ata act gaa gag agt tag                      516
 Thr Phe Leu Ser Leu His Ile Thr Glu Glu Ser 
                 165                 170





      <210> 749
      <211> 369
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (1)..(369)

      <400> 749
  atg ggc tcc tgc ctc ttc tcc tcc tta cag ccc ttc cct tcc tgg gct      48
  Met Gly Ser Cys Leu Phe Ser Ser Leu Gln Pro Phe Pro Ser Trp Ala
    1               5                  10                  15

 gtc ctc aag ggc ctg agt tat gcc tcc cag act agg ggc ctg gaa ttg       96
 Val Leu Lys Gly Leu Ser Tyr Ala Ser Gln Thr Arg Gly Leu Glu Leu
              20                  25                  30

 tgg ccc aag ctg act cct gtc cag atg tac act ggg agc ttt acc tac      144
 Trp Pro Lys Leu Thr Pro Val Gln Met Tyr Thr Gly Ser Phe Thr Tyr
          35                  40                  45

 tgg gtg cga tct atg ctt tcc aga cac aaa ctg gac gcc atc ctg ggc      192
 Trp Val Arg Ser Met Leu Ser Arg His Lys Leu Asp Ala Ile Leu Gly
      50                  55                  60

 agg ctg ggc tac acg gcc acc ttg gag tct gag ttc tca ctg gtc cag      240
 Arg Leu Gly Tyr Thr Ala Thr Leu Glu Ser Glu Phe Ser Leu Val Gln
  65                  70                  75                  80

 gcc atc agc aaa gag aat gtc aag cag atg gtg ttc aag atc ttc ctg      288
 Ala Ile Ser Lys Glu Asn Val Lys Gln Met Val Phe Lys Ile Phe Leu
                  85                  90                  95

 gaa cac agc tcc tca cca gca aca gaa caa agc tgg acg gag aat gac      336
 Glu His Ser Ser Ser Pro Ala Thr Glu Gln Ser Trp Thr Glu Asn Asp
             100                 105                 110

 ttt gac gag ttg aga gaa gaa ggc ttc aga tga                          369
 Phe Asp Glu Leu Arg Glu Glu Gly Phe Arg 
         115                 120





      <210> 750
      <211> 1008
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (1)..(1008)

      <400> 750
  atg gcc aag ggg atc cct ctt ggc act cta tct ggc ttg tgg gcc agt      48
  Met Ala Lys Gly Ile Pro Leu Gly Thr Leu Ser Gly Leu Trp Ala Ser
    1               5                  10                  15

 ttc cag tgc ctg atg agt ggt acc tat gga gat gcc atg gag cca agt       96
 Phe Gln Cys Leu Met Ser Gly Thr Tyr Gly Asp Ala Met Glu Pro Ser
              20                  25                  30

 cct gaa gca tgg gta tgt gta aag gga ctt tgg ttc tgg gct ttg ggt      144
 Pro Glu Ala Trp Val Cys Val Lys Gly Leu Trp Phe Trp Ala Leu Gly
          35                  40                  45

 ggt aat ggc acc agt gcc tgg ggc aca gga acc ccc act gct gtg ttg      192
 Gly Asn Gly Thr Ser Ala Trp Gly Thr Gly Thr Pro Thr Ala Val Leu
      50                  55                  60

 gtg atg gta tgt ttt gcc agt cag tca gat gat gat cag gtg aat gta      240
 Val Met Val Cys Phe Ala Ser Gln Ser Asp Asp Asp Gln Val Asn Val
  65                  70                  75                  80

 atg ggt ttt cac ttc tta gga ggt gct cga att act gtt ctt gct tcc      288
 Met Gly Phe His Phe Leu Gly Gly Ala Arg Ile Thr Val Leu Ala Ser
                  85                  90                  95

 aaa act tct cga gca gct gca cgg gag ctg gag gag ctg atg act agc      336
 Lys Thr Ser Arg Ala Ala Ala Arg Glu Leu Glu Glu Leu Met Thr Ser
             100                 105                 110

 ctg ttt gag gaa gcc cac aag atg gtg tgg gaa gcc agc ata cag cag      384
 Leu Phe Glu Glu Ala His Lys Met Val Trp Glu Ala Ser Ile Gln Gln
         115                 120                 125

 gca gtg tca gaa aag cag ctg aat gcg gag gca tgg gga aag ata gac      432
 Ala Val Ser Glu Lys Gln Leu Asn Ala Glu Ala Trp Gly Lys Ile Asp
     130                 135                 140

 atg ctg cag gca gag ggt gta gtg gga gga tat gga ccc ctg cct gga      480
 Met Leu Gln Ala Glu Gly Val Val Gly Gly Tyr Gly Pro Leu Pro Gly
 145                 150                 155                 160

 ctt cac agt gca gaa tct ctt gcc aca ggt gta ggc ctc tat ggg gga      528
 Leu His Ser Ala Glu Ser Leu Ala Thr Gly Val Gly Leu Tyr Gly Gly
                 165                 170                 175

 cac cac act cac tat caa gcc tgt ggc tct gca gaa gct gcc tat agt      576
 His His Thr His Tyr Gln Ala Cys Gly Ser Ala Glu Ala Ala Tyr Ser
             180                 185                 190

 gag gaa cga tat cgc att cag agt gaa caa ttt gaa gat ctt tgg ctc      624
 Glu Glu Arg Tyr Arg Ile Gln Ser Glu Gln Phe Glu Asp Leu Trp Leu
         195                 200                 205

 ata acc aat gag ctt att ctt cgc ctt caa gaa tat ttt gaa aaa cag      672
 Ile Thr Asn Glu Leu Ile Leu Arg Leu Gln Glu Tyr Phe Glu Lys Gln
     210                 215                 220

 gga gtc aaa gat ttt gca tgt tct ttt tcg gga tct ata ccc ctt caa      720
 Gly Val Lys Asp Phe Ala Cys Ser Phe Ser Gly Ser Ile Pro Leu Gln
 225                 230                 235                 240

 gaa tat ttt gag ttg att gat cat cat ttt gag cta cgg ata aat ggt      768
 Glu Tyr Phe Glu Leu Ile Asp His His Phe Glu Leu Arg Ile Asn Gly
                 245                 250                 255

 gaa aaa tta gaa gaa ctc tta tct gag aga gct gta caa ttt cgg gcc      816
 Glu Lys Leu Glu Glu Leu Leu Ser Glu Arg Ala Val Gln Phe Arg Ala
             260                 265                 270

 att caa cgc cgg cta cta gca aga ttc aaa gat aaa act cct gcc cct      864
 Ile Gln Arg Arg Leu Leu Ala Arg Phe Lys Asp Lys Thr Pro Ala Pro
         275                 280                 285

 ctt caa cac ctg gac acc ttg tta gat gga acc tac aag cag agt gtg      912
 Leu Gln His Leu Asp Thr Leu Leu Asp Gly Thr Tyr Lys Gln Ser Val
     290                 295                 300

 tct cct cac gcc ctt gct aaa tcc agg cca tgg tcc caa gga agc cca      960
 Ser Pro His Ala Leu Ala Lys Ser Arg Pro Trp Ser Gln Gly Ser Pro
 305                 310                 315                 320

 cag gtc ctg gtc ctt atg gtc aaa tgt gtc aac aaa ttg cct cat tag     1008
 Gln Val Leu Val Leu Met Val Lys Cys Val Asn Lys Leu Pro His 
                 325                 330                 335





      <210> 751
      <211> 5364
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (1)..(5364)

      <400> 751
  atg acc ctc cac ctg cac cca gac ctc tgg gtc ctt gct cag gca gcc      48
  Met Thr Leu His Leu His Pro Asp Leu Trp Val Leu Ala Gln Ala Ala
    1               5                  10                  15

 cct gcc ctc gtg gat gtg gcc acg gcg ctg cct ctg caa gtg gcc ccc       96
 Pro Ala Leu Val Asp Val Ala Thr Ala Leu Pro Leu Gln Val Ala Pro
              20                  25                  30

 tcg gca gtg ccc atg gac ctg cgc ctg gac cac cag ttc tca ctg cct      144
 Ser Ala Val Pro Met Asp Leu Arg Leu Asp His Gln Phe Ser Leu Pro
          35                  40                  45

 gtg gca gag ccg gcc ctg cgg gag cag cag ctg cag cag gag ctc ctg      192
 Val Ala Glu Pro Ala Leu Arg Glu Gln Gln Leu Gln Gln Glu Leu Leu
      50                  55                  60

 gcg ctc aag cag aag cag cag atc cag agg cag atc ctc atc gct gag      240
 Ala Leu Lys Gln Lys Gln Gln Ile Gln Arg Gln Ile Leu Ile Ala Glu
  65                  70                  75                  80

 ttc cag agg cag cac gag cag ctc tcc cgg cag cac gag gcg cag ctc      288
 Phe Gln Arg Gln His Glu Gln Leu Ser Arg Gln His Glu Ala Gln Leu
                  85                  90                  95

 cac gag cac atc aag aaa gtt cct cgg gcc act ctg gtt gcc agg atg      336
 His Glu His Ile Lys Lys Val Pro Arg Ala Thr Leu Val Ala Arg Met
             100                 105                 110

 cct gct tat ccc gta ccc tct cac cgt ccc ctc ttc ctc cat aag ggg      384
 Pro Ala Tyr Pro Val Pro Ser His Arg Pro Leu Phe Leu His Lys Gly
         115                 120                 125

 agc aag acc aac aaa aag caa ccc acc agt ggc cgg caa caa cag gag      432
 Ser Lys Thr Asn Lys Lys Gln Pro Thr Ser Gly Arg Gln Gln Gln Glu
     130                 135                 140

 atg ctg gcc atg aag cac cag cag gag ctg ctg gaa cac cag cgg aag      480
 Met Leu Ala Met Lys His Gln Gln Glu Leu Leu Glu His Gln Arg Lys
 145                 150                 155                 160

 ctg gag agg cac cgc cag gag cag gag ctg gag aag cag cac cgg gag      528
 Leu Glu Arg His Arg Gln Glu Gln Glu Leu Glu Lys Gln His Arg Glu
                 165                 170                 175

 cag aag ctg cag cag ctc aag aac aag gag aag ggc aaa gag agg tgt      576
 Gln Lys Leu Gln Gln Leu Lys Asn Lys Glu Lys Gly Lys Glu Arg Cys
             180                 185                 190

 tct gcc aaa ctg atc cca agt gga acc cgg ctg gca gtg ttc ttg ctt      624
 Ser Ala Lys Leu Ile Pro Ser Gly Thr Arg Leu Ala Val Phe Leu Leu
         195                 200                 205

 ctg aag ctg cct agt gcc gtg gcc agc aca gaa gtg aag atg aag tta      672
 Leu Lys Leu Pro Ser Ala Val Ala Ser Thr Glu Val Lys Met Lys Leu
     210                 215                 220

 caa gaa ttt gtc ctc aat aaa aag aag gcg ctg gcc cac cgg aat ctg      720
 Gln Glu Phe Val Leu Asn Lys Lys Lys Ala Leu Ala His Arg Asn Leu
 225                 230                 235                 240

 aac cac tgc att tcc agc gac cct cgc tac tgg tac ggg aaa acg cag      768
 Asn His Cys Ile Ser Ser Asp Pro Arg Tyr Trp Tyr Gly Lys Thr Gln
                 245                 250                 255

 cac agt tcc ctt gac cag agt tct cca ccc cag agc gga gtg tcg acc      816
 His Ser Ser Leu Asp Gln Ser Ser Pro Pro Gln Ser Gly Val Ser Thr
             260                 265                 270

 tcc tat aac cac ccg gtc ctg gga atg tac gac gcc aaa gat gac ttc      864
 Ser Tyr Asn His Pro Val Leu Gly Met Tyr Asp Ala Lys Asp Asp Phe
         275                 280                 285

 cct ctt agg aaa aca ggg ctc atc tcc tcg ctc ctg gct tgc ctt cac      912
 Pro Leu Arg Lys Thr Gly Leu Ile Ser Ser Leu Leu Ala Cys Leu His
     290                 295                 300

 ctg agt gcc atc tcc cag gag gag cct cca ccg ctg ggc ttg aga gtc      960
 Leu Ser Ala Ile Ser Gln Glu Glu Pro Pro Pro Leu Gly Leu Arg Val
 305                 310                 315                 320

 aga gac ctc tac cca ggg cct cag gtc cag ctc ttc ctg cca gag gcc     1008
 Arg Asp Leu Tyr Pro Gly Pro Gln Val Gln Leu Phe Leu Pro Glu Ala
                 325                 330                 335

 ccg ccc ctt tcc tgg gag att ggc agc agg ggt gtc tcc act tca gag     1056
 Pro Pro Leu Ser Trp Glu Ile Gly Ser Arg Gly Val Ser Thr Ser Glu
             340                 345                 350

 gtc ttc acc tcc cgc cag att tcg gcc cag gct tct gaa ccg aat ctg     1104
 Val Phe Thr Ser Arg Gln Ile Ser Ala Gln Ala Ser Glu Pro Asn Leu
         355                 360                 365

 aaa tta cgg tcc agg cta aag cag aaa gtg gcc gaa aga cgg agc agc     1152
 Lys Leu Arg Ser Arg Leu Lys Gln Lys Val Ala Glu Arg Arg Ser Ser
     370                 375                 380

 ccc ctg tta cgc agg aaa gac ggg cca gtg gtc act gct cta aaa aag     1200
 Pro Leu Leu Arg Arg Lys Asp Gly Pro Val Val Thr Ala Leu Lys Lys
 385                 390                 395                 400

 cgt ccg ttg gat gtc aca gac tcc gcg tgc agc agc gcc cca ggc tcc     1248
 Arg Pro Leu Asp Val Thr Asp Ser Ala Cys Ser Ser Ala Pro Gly Ser
                 405                 410                 415

 gga ccc agc tca ccc aac aac agc tcc ggg agc gtc agc gcg gag aac     1296
 Gly Pro Ser Ser Pro Asn Asn Ser Ser Gly Ser Val Ser Ala Glu Asn
             420                 425                 430

 ggt atc gcg ccc gcc gtc ccc agc atc ccg gcg gag acg agt ttg gcg     1344
 Gly Ile Ala Pro Ala Val Pro Ser Ile Pro Ala Glu Thr Ser Leu Ala
         435                 440                 445

 cac aga ctt gtg gca cga gaa ggc tcg gcc gct cca ctt ccc ctc tac     1392
 His Arg Leu Val Ala Arg Glu Gly Ser Ala Ala Pro Leu Pro Leu Tyr
     450                 455                 460

 aca tcg cca tcc ttg ccc aac atc acg ctg ggc ctg cct gcc acc ggc     1440
 Thr Ser Pro Ser Leu Pro Asn Ile Thr Leu Gly Leu Pro Ala Thr Gly
 465                 470                 475                 480

 ccc tct gcg ggc acg gcg ggc cag cag gac gcc gag aga ctc acc ctt     1488
 Pro Ser Ala Gly Thr Ala Gly Gln Gln Asp Ala Glu Arg Leu Thr Leu
                 485                 490                 495

 ccc gcc ctc cag cag agg ctc tcc ctt ttc ccc ggc acc cac ctc act     1536
 Pro Ala Leu Gln Gln Arg Leu Ser Leu Phe Pro Gly Thr His Leu Thr
             500                 505                 510

 ccc tac ctg agc acc tcg ccc ttg gag cgg gac gga ggg gca gcg cac     1584
 Pro Tyr Leu Ser Thr Ser Pro Leu Glu Arg Asp Gly Gly Ala Ala His
         515                 520                 525

 agc cct ctt ctg cag cac atg gtc tta ctg gag cag ccg ccg gca caa     1632
 Ser Pro Leu Leu Gln His Met Val Leu Leu Glu Gln Pro Pro Ala Gln
     530                 535                 540

 gca ccc ctc gtc aca ggc ctg gga gca ctg ccc ctc cac gca cag tcc     1680
 Ala Pro Leu Val Thr Gly Leu Gly Ala Leu Pro Leu His Ala Gln Ser
 545                 550                 555                 560

 ttg gtt ggt gca gac cgg gtg tcc ccc tcc atc cac aag ctg cgg cag     1728
 Leu Val Gly Ala Asp Arg Val Ser Pro Ser Ile His Lys Leu Arg Gln
                 565                 570                 575

 cac cgc cca ctg ggg cgg acc cag tcg gcc ccg ctg ccc cag aac gcc     1776
 His Arg Pro Leu Gly Arg Thr Gln Ser Ala Pro Leu Pro Gln Asn Ala
             580                 585                 590

 cag gct ctg cag cac ctg gtc atc cag cag cag cat cag cag ttt ctg     1824
 Gln Ala Leu Gln His Leu Val Ile Gln Gln Gln His Gln Gln Phe Leu
         595                 600                 605

 gag aaa cac aag cag cag ttc cag cag cag caa ctg cag atg aac aag     1872
 Glu Lys His Lys Gln Gln Phe Gln Gln Gln Gln Leu Gln Met Asn Lys
     610                 615                 620

 atc atc ccc aag cca agc gag cca gcc cgg cag ccg gag agc cac ccg     1920
 Ile Ile Pro Lys Pro Ser Glu Pro Ala Arg Gln Pro Glu Ser His Pro
 625                 630                 635                 640

 gag gag acg gag gag gag ctc cgt gag cac cag gct ctg ctg gac gag     1968
 Glu Glu Thr Glu Glu Glu Leu Arg Glu His Gln Ala Leu Leu Asp Glu
                 645                 650                 655

 ccc tac ctg gac cgg ctg ccg ggg cag aag gag gcg cac gca cag gcc     2016
 Pro Tyr Leu Asp Arg Leu Pro Gly Gln Lys Glu Ala His Ala Gln Ala
             660                 665                 670

 ggc gtg cag gtg aag cag gag ccc att gag agc gat gag gaa gag gca     2064
 Gly Val Gln Val Lys Gln Glu Pro Ile Glu Ser Asp Glu Glu Glu Ala
         675                 680                 685

 gag ccc cca cgg gag gtg gag ccg ggc cag cgc cag ccc agt gag cag     2112
 Glu Pro Pro Arg Glu Val Glu Pro Gly Gln Arg Gln Pro Ser Glu Gln
     690                 695                 700

 gag ctg ctc ttc aga cag caa gcc ctc ctg ctg gag cag cag cgg atc     2160
 Glu Leu Leu Phe Arg Gln Gln Ala Leu Leu Leu Glu Gln Gln Arg Ile
 705                 710                 715                 720

 cac cag ctg agg aac tac cag gcg tcc atg gag gcc gcc ggc atc ccc     2208
 His Gln Leu Arg Asn Tyr Gln Ala Ser Met Glu Ala Ala Gly Ile Pro
                 725                 730                 735

 gtg tcc ttc ggc ggc cac agg cct ctg tcc cgg gcg cag tcc tca ccc     2256
 Val Ser Phe Gly Gly His Arg Pro Leu Ser Arg Ala Gln Ser Ser Pro
             740                 745                 750

 gcg tct gcc acc ttc ccc gtg tct gtg cag gag ccc ccc acc aag ccg     2304
 Ala Ser Ala Thr Phe Pro Val Ser Val Gln Glu Pro Pro Thr Lys Pro
         755                 760                 765

 agg ttc acg aca gct ttt ctg tct gta aag gca gta aag cag gtg tct     2352
 Arg Phe Thr Thr Ala Phe Leu Ser Val Lys Ala Val Lys Gln Val Ser
     770                 775                 780

 gcc tct aat agg aac aca agt ggg gag ggc cgc atc ctg ggc cag cac     2400
 Ala Ser Asn Arg Asn Thr Ser Gly Glu Gly Arg Ile Leu Gly Gln His
 785                 790                 795                 800

 act gaa gca ata gag cag gtc tgt ctg ggc agc ttg ccc agg ctc ttc     2448
 Thr Glu Ala Ile Glu Gln Val Cys Leu Gly Ser Leu Pro Arg Leu Phe
                 805                 810                 815

 acc gtg cgc ccc gcc ctt atc agc ctg gat gaa ccc aca tta gca cag     2496
 Thr Val Arg Pro Ala Leu Ile Ser Leu Asp Glu Pro Thr Leu Ala Gln
             820                 825                 830

 gtg ccc ctg gcc agt gac ctg cct gcg gaa ggc gtc tgt tca ccc agc     2544
 Val Pro Leu Ala Ser Asp Leu Pro Ala Glu Gly Val Cys Ser Pro Ser
         835                 840                 845

 ctg gcc ttc cct ttg tta agt cct gga aga cca ggc ctc gtg tat gac     2592
 Leu Ala Phe Pro Leu Leu Ser Pro Gly Arg Pro Gly Leu Val Tyr Asp
     850                 855                 860

 acg ctg atg ctg aag cac cag tgc acc tgc ggg agt agc agc agc cac     2640
 Thr Leu Met Leu Lys His Gln Cys Thr Cys Gly Ser Ser Ser Ser His
 865                 870                 875                 880

 ccc gag cac gcc ggg agg atc cag agc atc tgg tcc cgc ctg cag gag     2688
 Pro Glu His Ala Gly Arg Ile Gln Ser Ile Trp Ser Arg Leu Gln Glu
                 885                 890                 895

 acg ggc ctc cgg ggc aaa tgc gag tgc atc cgc gga cgc aag gcc acc     2736
 Thr Gly Leu Arg Gly Lys Cys Glu Cys Ile Arg Gly Arg Lys Ala Thr
             900                 905                 910

 ctg gag gag cta cag acg gtg cac tcg gaa gcc cac acc ctc ctg tat     2784
 Leu Glu Glu Leu Gln Thr Val His Ser Glu Ala His Thr Leu Leu Tyr
         915                 920                 925

 ggc acg aac ccc ctc aac cgg cag aaa ctg gac aga gcg gac aac caa     2832
 Gly Thr Asn Pro Leu Asn Arg Gln Lys Leu Asp Arg Ala Asp Asn Gln
     930                 935                 940

 gga gga ccc agg gcc cga gga acg gct gga cag gga cct gga gct gga     2880
 Gly Gly Pro Arg Ala Arg Gly Thr Ala Gly Gln Gly Pro Gly Ala Gly
 945                 950                 955                 960

 gcc aca cag ggg aag gag gct ggg ggc aga cag tgt gag gca cta acc     2928
 Ala Thr Gln Gly Lys Glu Ala Gly Gly Arg Gln Cys Glu Ala Leu Thr
                 965                 970                 975

 cag ctg cca tta gca ccc tca gag agg atg cca cat cca cgt aac gtg     2976
 Gln Leu Pro Leu Ala Pro Ser Glu Arg Met Pro His Pro Arg Asn Val
             980                 985                 990

 gac aag ttc agt gga aaa ggg gaa agc aca gaa cgt tca gag aag aca     3024
 Asp Lys Phe Ser Gly Lys Gly Glu Ser Thr Glu Arg Ser Glu Lys Thr
         995                1000                1005

 aaa att aaa cac ctg acc gca gaa aaa gaa aat cct cct cag act gga     3072
 Lys Ile Lys His Leu Thr Ala Glu Lys Glu Asn Pro Pro Gln Thr Gly
    1010                1015                1020

 aga tac ggt gat gtc atc tcc cag aaa ctg gag caa aac gtg aca gct     3120
 Arg Tyr Gly Asp Val Ile Ser Gln Lys Leu Glu Gln Asn Val Thr Ala
1025                1030                1035                1040

 ctg gga aac tgg gaa gct cgc tcg cct ccg tgt tcg tcc ggc tcc ctt     3168
 Leu Gly Asn Trp Glu Ala Arg Ser Pro Pro Cys Ser Ser Gly Ser Leu
                1045                1050                1055

 gcg gtg gtg ttg ggt gac cgc aag ttt caa ctg ggt gag gag ctg gtg     3216
 Ala Val Val Leu Gly Asp Arg Lys Phe Gln Leu Gly Glu Glu Leu Val
            1060                1065                1070

 tcc ctg ctc ggc ctc gcc cag cgg agt cct ggc ctg ctc tct tca gca     3264
 Ser Leu Leu Gly Leu Ala Gln Arg Ser Pro Gly Leu Leu Ser Ser Ala
        1075                1080                1085

 tcc cta atc caa aaa tct gaa atc cag aat gct cca gag tgc att tcc     3312
 Ser Leu Ile Gln Lys Ser Glu Ile Gln Asn Ala Pro Glu Cys Ile Ser
    1090                1095                1100

 ttt gag cgt cac gtg gac agt gac acc ata tgg aac gag gtg cac tcg     3360
 Phe Glu Arg His Val Asp Ser Asp Thr Ile Trp Asn Glu Val His Ser
1105                1110                1115                1120

 gcg ggg gca gcc cgc ctg gct gtg ggc tgc gtg gta gag ctg gtc ttc     3408
 Ala Gly Ala Ala Arg Leu Ala Val Gly Cys Val Val Glu Leu Val Phe
                1125                1130                1135

 aag gtg gcc aca ggg gag ctg aag gga aga gac tac gtg cga gat agt     3456
 Lys Val Ala Thr Gly Glu Leu Lys Gly Arg Asp Tyr Val Arg Asp Ser
            1140                1145                1150

 cag atc cgc gtg tta gag cag agt ctc ctt cat gtg cag gga gga gac     3504
 Gln Ile Arg Val Leu Glu Gln Ser Leu Leu His Val Gln Gly Gly Asp
        1155                1160                1165

 tgg aag aga ctg tac gtg cga gat agt cag atc cgc gtg tta gag cag     3552
 Trp Lys Arg Leu Tyr Val Arg Asp Ser Gln Ile Arg Val Leu Glu Gln
    1170                1175                1180

 agt ctc ctt cgt gta cag gga aga gac tac gtg cga gat agt cag atc     3600
 Ser Leu Leu Arg Val Gln Gly Arg Asp Tyr Val Arg Asp Ser Gln Ile
1185                1190                1195                1200

 cgc gtg tta gag cag agt ctc ctt cat gtg cag gga gga gac tgg aag     3648
 Arg Val Leu Glu Gln Ser Leu Leu His Val Gln Gly Gly Asp Trp Lys
                1205                1210                1215

 aga ctg tac gtg cga gat agt cag atc cgc gtg tta gag cag agt ctc     3696
 Arg Leu Tyr Val Arg Asp Ser Gln Ile Arg Val Leu Glu Gln Ser Leu
            1220                1225                1230

 ctt cgt gta cag gga gga gac tcg tca gtt ctc tcc cgc agg ggc ttt     3744
 Leu Arg Val Gln Gly Gly Asp Ser Ser Val Leu Ser Arg Arg Gly Phe
        1235                1240                1245

 tgc tac ttc aac tcc gtg gcc gtg gca gcc aag ctt ctg cag cag agg     3792
 Cys Tyr Phe Asn Ser Val Ala Val Ala Ala Lys Leu Leu Gln Gln Arg
    1250                1255                1260

 ttg agc gtg agc aag atc ctc atc gtg gac tgg gac gtg cac cat gga     3840
 Leu Ser Val Ser Lys Ile Leu Ile Val Asp Trp Asp Val His His Gly
1265                1270                1275                1280

 aac ggg acc cag cag gct ttc tac agc gac ccc agc gtc ctg tac atg     3888
 Asn Gly Thr Gln Gln Ala Phe Tyr Ser Asp Pro Ser Val Leu Tyr Met
                1285                1290                1295

 tcc ctc cac cgc tac gac gat ggg aac ttc ttc cca ggc agc ggg gct     3936
 Ser Leu His Arg Tyr Asp Asp Gly Asn Phe Phe Pro Gly Ser Gly Ala
            1300                1305                1310

 cct gat gag gtg ggc aca ggg ccc ggc gtg ggt ttc aac gtc aac atg     3984
 Pro Asp Glu Val Gly Thr Gly Pro Gly Val Gly Phe Asn Val Asn Met
        1315                1320                1325

 gct ttc acc ggc ggc ctg gac ccc ccc atg gga gac gct gag tac ttg     4032
 Ala Phe Thr Gly Gly Leu Asp Pro Pro Met Gly Asp Ala Glu Tyr Leu
    1330                1335                1340

 gcg gcc ttc aga acg gtg gtc atg ccg atc gcc agc gag ttt gcc ccg     4080
 Ala Ala Phe Arg Thr Val Val Met Pro Ile Ala Ser Glu Phe Ala Pro
1345                1350                1355                1360

 gat gtg gtg ctg gtg tca tca ggc ttc gat gcc gtg gag ggc cac ccc     4128
 Asp Val Val Leu Val Ser Ser Gly Phe Asp Ala Val Glu Gly His Pro
                1365                1370                1375

 acc cct ctt ggg ggc tac aac ctc tcc gcc aga tgc ttc ggg tac ctg     4176
 Thr Pro Leu Gly Gly Tyr Asn Leu Ser Ala Arg Cys Phe Gly Tyr Leu
            1380                1385                1390

 acg aag cag ctg atg ggc ctg gct ggc ggc cgg att gtc ctg gcc ctc     4224
 Thr Lys Gln Leu Met Gly Leu Ala Gly Gly Arg Ile Val Leu Ala Leu
        1395                1400                1405

 gag gga ggc cac gac ctg acc gcc att tgc gac gcc tcg gaa gca tgt     4272
 Glu Gly Gly His Asp Leu Thr Ala Ile Cys Asp Ala Ser Glu Ala Cys
    1410                1415                1420

 gtt tct gcc ttg ctg gga aac gag tgc aaa ccc cat tat gag agg aac     4320
 Val Ser Ala Leu Leu Gly Asn Glu Cys Lys Pro His Tyr Glu Arg Asn
1425                1430                1435                1440

 ccc act ggt cac agc cag ttc cca cct cca cca cct ctg ccg tct gtc     4368
 Pro Thr Gly His Ser Gln Phe Pro Pro Pro Pro Pro Leu Pro Ser Val
                1445                1450                1455

 cct ggg aag cag gtt gct ttc caa acg gtt ggt aac tcg ctg cta act     4416
 Pro Gly Lys Gln Val Ala Phe Gln Thr Val Gly Asn Ser Leu Leu Thr
            1460                1465                1470

 ggg tgc tgc ttt agc cga gga agc caa aag gtt tta cag caa aga ccc     4464
 Gly Cys Cys Phe Ser Arg Gly Ser Gln Lys Val Leu Gln Gln Arg Pro
        1475                1480                1485

 aat gca aac gct gtc cgt tcc atg gag aaa gtc atg gag atc cac agc     4512
 Asn Ala Asn Ala Val Arg Ser Met Glu Lys Val Met Glu Ile His Ser
    1490                1495                1500

 aag tac tgg cgc tgc ctg cag cgc aca acc tcc aca gcg ggg cgt tct     4560
 Lys Tyr Trp Arg Cys Leu Gln Arg Thr Thr Ser Thr Ala Gly Arg Ser
1505                1510                1515                1520

 ctg atc gag gct cag act tgc gag aac gaa gaa gcc gag acg gtc acc     4608
 Leu Ile Glu Ala Gln Thr Cys Glu Asn Glu Glu Ala Glu Thr Val Thr
                1525                1530                1535

 gcc atg gcc tcg ctg tcc gtg ggc gtg aag ccc gcc gaa aag agg tgc     4656
 Ala Met Ala Ser Leu Ser Val Gly Val Lys Pro Ala Glu Lys Arg Cys
            1540                1545                1550

 cca cct gtc caa gtg gag aca gca gct ctg ctg tta cag aag aaa ggg     4704
 Pro Pro Val Gln Val Glu Thr Ala Ala Leu Leu Leu Gln Lys Lys Gly
        1555                1560                1565

 agg gtg ggt act gag aga cac cag agt ctc tgc cac aga acc aag aac     4752
 Arg Val Gly Thr Glu Arg His Gln Ser Leu Cys His Arg Thr Lys Asn
    1570                1575                1580

 acc tgc aaa cct tac caa cac atg agg aac cac tgt acc cag gta cct     4800
 Thr Cys Lys Pro Tyr Gln His Met Arg Asn His Cys Thr Gln Val Pro
1585                1590                1595                1600

 cac aac ccc cag ggc ctt cct atg agg tcc aca ctc tac ctg aaa gac     4848
 His Asn Pro Gln Gly Leu Pro Met Arg Ser Thr Leu Tyr Leu Lys Asp
                1605                1610                1615

 atc tgt gcc agt ggg aag gcg gag ggt cag gga tgg tgc tgc ctg gac     4896
 Ile Cys Ala Ser Gly Lys Ala Glu Gly Gln Gly Trp Cys Cys Leu Asp
            1620                1625                1630

 tct ctg gaa gca atc gtg gga gcc ttc ccc aga gaa gaa ggt ggt aca     4944
 Ser Leu Glu Ala Ile Val Gly Ala Phe Pro Arg Glu Glu Gly Gly Thr
        1635                1640                1645

 cac agg tcc aag ttc ccc agg ctg tac agg aag cat gag gct ggc atc     4992
 His Arg Ser Lys Phe Pro Arg Leu Tyr Arg Lys His Glu Ala Gly Ile
    1650                1655                1660

 tgt tcg gcc tcc ggg gag gcc tca gga aac gtc cag tta tgg cag aag     5040
 Cys Ser Ala Ser Gly Glu Ala Ser Gly Asn Val Gln Leu Trp Gln Lys
1665                1670                1675                1680

 ggg aag cag atc ctg gca gaa acg gtc tcc cac acc cat atg ccc act     5088
 Gly Lys Gln Ile Leu Ala Glu Thr Val Ser His Thr His Met Pro Thr
                1685                1690                1695

 gcc acc gaa ctg aga gtc ctg cct cgc gcc ttc tgc cct caa aag aga     5136
 Ala Thr Glu Leu Arg Val Leu Pro Arg Ala Phe Cys Pro Gln Lys Arg
            1700                1705                1710

 atc cga ctg gca tct gtt cag ctc tcc tca gcc cac gca gac aca gaa     5184
 Ile Arg Leu Ala Ser Val Gln Leu Ser Ser Ala His Ala Asp Thr Glu
        1715                1720                1725

 cac atg ctt cac aca agt ggg ccc acg gct gtc ttg gag acc agc atc     5232
 His Met Leu His Thr Ser Gly Pro Thr Ala Val Leu Glu Thr Ser Ile
    1730                1735                1740

 acg ctg acc gcc agc atg gga aag cca gct cca tcc tgc cgg ctg ggc     5280
 Thr Leu Thr Ala Ser Met Gly Lys Pro Ala Pro Ser Cys Arg Leu Gly
1745                1750                1755                1760

 tcc ttg aag gca caa acc agt tcc tgc ctc cag gcc ttt gca cag gct     5328
 Ser Leu Lys Ala Gln Thr Ser Ser Cys Leu Gln Ala Phe Ala Gln Ala
                1765                1770                1775

 gtt ccc ccg cct gga ata cct ttc ccc acc tgg tga                     5364
 Val Pro Pro Pro Gly Ile Pro Phe Pro Thr Trp 
            1780                1785





      <210> 752
      <211> 621
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (332)..(621)

      <400> 752
 atgatggtgc atgaaggtgt ctacagcaag cagacatctg ttctcccggc ctggcaggga     60

 gaaggtgaga aaataagaag acagcgaaca aaccccagta cacaatgcct gggggtgtgg    120

 ccaggggcac tgaaaagtct acaaacctgc tccatggagt gggacagtgc ccctttacca    180

 acgggctccc caccaacatc cagaaccaaa gcaaggcaac tcacctgtcc actagagaat    240

 acgaacacga gagctgcccc agctgctgtc atcccccagg tgaagaaggt ccccagcaag    300

 gcctggaaca cagagctgtg gccttggagc a   tgc tgg ata cag ctg tgc aag     352
                                      Met Leu Gln Gly His Ser Ser
                                        1               5

 agg agc gag agg gag cag cat tga tca cgg gca atg caa gcc cag tgc      400
 Val Phe Gln Ala Leu Leu Gly Thr Phe Phe Thr Trp Gly Met Thr Ala
          10                  15                  20

 ccc tcg gag aag ttt ctt ctc tat ttg ctg ttt taa atc ctc gct aca      448
 Ala Gly Ala Ala Leu Val Phe Val Phe Ser Ser Gly Gln Val Ser Cys
      25                  30                  35

 agg gtg gtc aga gaa cca gca gca ctg att tca aga aac aga atg cag      496
 Leu Ala Leu Val Leu Asp Val Gly Gly Glu Pro Val Gly Lys Gly Ala
  40                  45                  50                  55

 cag tcc aga aca ttt tga ctc tag tgg ttg ctt tgc cag gat ttc tca      544
 Leu Ser His Ser Met Glu Gln Val Cys Arg Leu Phe Ser Ala Pro Gly
                  60                  65                  70

 acc tga gcg cca ctg gca ttc tgc gcg gca cat tcc ttg ctg tgg ggc      592
 His Thr Pro Arg His Cys Val Leu Gly Phe Val Arg Cys Leu Leu Ile
              75                  80                  85

 tgt cct gtg cat gtg acc agg gca agt ag                               621
 Phe Ser Pro Ser Pro Cys Gln Ala Gly Arg Thr Asp Val Cys Leu Leu 
          90                  95                 100





      <210> 753
      <211> 1128
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (1)..(1128)

      <400> 753
  atg ata gtg gtg att tta ttt gtt gta gcc aat ggc ttg gta caa gtt      48
  Met Ile Val Val Ile Leu Phe Val Val Ala Asn Gly Leu Val Gln Val
    1               5                  10                  15

 gga gtt ttg gat aat ggt gag caa aga tta caa tca tat agc tat gtc       96
 Gly Val Leu Asp Asn Gly Glu Gln Arg Leu Gln Ser Tyr Ser Tyr Val
              20                  25                  30

 aac ctt tct gca tgt aaa agt gca tat agt ctg att ata gat gtt tcg      144
 Asn Leu Ser Ala Cys Lys Ser Ala Tyr Ser Leu Ile Ile Asp Val Ser
          35                  40                  45

 gat tca ctt aaa gga gac acg ggc tgt gct ggc ttc tca gat ttg caa      192
 Asp Ser Leu Lys Gly Asp Thr Gly Cys Ala Gly Phe Ser Asp Leu Gln
      50                  55                  60

 aag atc aat gtc tcc aag tac cca aaa ctt acc tgg ggt ttt caa gat      240
 Lys Ile Asn Val Ser Lys Tyr Pro Lys Leu Thr Trp Gly Phe Gln Asp
  65                  70                  75                  80

 tat gca gct agg aaa gtt gga gtc aga cct ctg gcc aat aga agg gca      288
 Tyr Ala Ala Arg Lys Val Gly Val Arg Pro Leu Ala Asn Arg Arg Ala
                  85                  90                  95

 ctg acg aat ccc tac aca gcc cgg cac ata aaa tat tta tac tca gag      336
 Leu Thr Asn Pro Tyr Thr Ala Arg His Ile Lys Tyr Leu Tyr Ser Glu
             100                 105                 110

 aaa gct aca cta agt act gaa ttc ttt ctt ctg agg agg caa gaa ttc      384
 Lys Ala Thr Leu Ser Thr Glu Phe Phe Leu Leu Arg Arg Gln Glu Phe
         115                 120                 125

 agg ttg ctg cag acc cga ccg gat tta ccg ctg gta gct cag ata act      432
 Arg Leu Leu Gln Thr Arg Pro Asp Leu Pro Leu Val Ala Gln Ile Thr
     130                 135                 140

 tct gct gct ggt aac aaa ttt gtg cac gag gca agg atg aga aag gtc      480
 Ser Ala Ala Gly Asn Lys Phe Val His Glu Ala Arg Met Arg Lys Val
 145                 150                 155                 160

 aaa act tta gat ttc ttt cca ttt ctg gta tgg ctg aac aag ctc cta      528
 Lys Thr Leu Asp Phe Phe Pro Phe Leu Val Trp Leu Asn Lys Leu Leu
                 165                 170                 175

 ctg cct gac act ctt gga gat aac act tat aaa ctg tgg gga aaa aaa      576
 Leu Pro Asp Thr Leu Gly Asp Asn Thr Tyr Lys Leu Trp Gly Lys Lys
             180                 185                 190

 ata cag aga gac aat gac tca aag ccc ggt tat gag gct ctc aac cct      624
 Ile Gln Arg Asp Asn Asp Ser Lys Pro Gly Tyr Glu Ala Leu Asn Pro
         195                 200                 205

 atc cct gtt cgg ctc gat aat gag gcc ctc aac gct atc tct gca ctc      672
 Ile Pro Val Arg Leu Asp Asn Glu Ala Leu Asn Ala Ile Ser Ala Leu
     210                 215                 220

 aat tct gcc ttt ctt tct atg cat cag gct cct cag aag tct gac ttg      720
 Asn Ser Ala Phe Leu Ser Met His Gln Ala Pro Gln Lys Ser Asp Leu
 225                 230                 235                 240

 cag tca gtg cac cag cct gga act cag gcc ctg cag tca atg cac cag      768
 Gln Ser Val His Gln Pro Gly Thr Gln Ala Leu Gln Ser Met His Gln
                 245                 250                 255

 cct gga act cag gcc ctg cag tca atg cag cag cct gga gtt cag gcc      816
 Pro Gly Thr Gln Ala Leu Gln Ser Met Gln Gln Pro Gly Val Gln Ala
             260                 265                 270

 tct gaa aga cct gca cag cag gca acc gcg cgt cag cct ggc tta aag      864
 Ser Glu Arg Pro Ala Gln Gln Ala Thr Ala Arg Gln Pro Gly Leu Lys
         275                 280                 285

 gct ctc aat ttc tcc tct att caa aac tcc aat ttc ctt tct gct tct      912
 Ala Leu Asn Phe Ser Ser Ile Gln Asn Ser Asn Phe Leu Ser Ala Ser
     290                 295                 300

 ggt ccg gtc aca act gct gtt act acc cat aag caa cag gtt aca tac      960
 Gly Pro Val Thr Thr Ala Val Thr Thr His Lys Gln Gln Val Thr Tyr
 305                 310                 315                 320

 ctt cct gat aat gac acc cct ctt atg agg gcc att tct cag gca agg     1008
 Leu Pro Asp Asn Asp Thr Pro Leu Met Arg Ala Ile Ser Gln Ala Arg
                 325                 330                 335

 gaa tat ggg gat ccc gag gca tgg cag ttt cct gtt att tta caa tct     1056
 Glu Tyr Gly Asp Pro Glu Ala Trp Gln Phe Pro Val Ile Leu Gln Ser
             340                 345                 350

 gct ata cct gct gcc tct att cct gcc gcc cct gct cca gct ggc tgc     1104
 Ala Ile Pro Ala Ala Ser Ile Pro Ala Ala Pro Ala Pro Ala Gly Cys
         355                 360                 365

 acc agt tca gcc aca gcc ctt tga                                     1128
 Thr Ser Ser Ala Thr Ala Leu 
     370                 375





      <210> 754
      <211> 1962
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (1071)..(1376)

      <400> 754
 atgtcatcgg gccggcggga cgcattagcc agagggctgg gaaacagcgg agatggcgcg     60

 ccccacctgg gagaacacag gcagctggag gacgtcggcg gtgttactgt cacggtcacc    120

 tggactgggc ggttgcaggc ggccggatgc tggacccgca gcgtgagctc cacggccgca    180

 gcagggaggc gagagccctc aaccagggac ggagccgccc tgtccacgga gcctccagac    240

 ccaccagaac gcctgggtca ccgcggctcc cgggcgggcc tcactgcgct gggacacgtc    300

 aggacacgtg gcagctccca gcgcggtgga aggcctgagc cctgggaaca ctggctggaa    360

 aatggaactc ggaggacaga gcttgtcgac ggcgtctcgt atgaatcctg gaggagacgc    420

 ccgtgtcgag ggcaattaga atccaggcaa cagaggctcg tggtaacgcg tacagagatg    480

 gtacatccct gtcctctcat caaagtgatt cctctccctt ttgccaaact tccacagaag    540

 ccaaataaac agtgtagaca ctccgtcact cgctacggcc acggcggcca ctcggatcac    600

 actccgtcac tcactgtggc cacagtggcc actcagatca caccccgtca ctcgggccac    660

 ggcagccact gtgatcgcaa cctgtcactt gctacagcca cagcagccac tctgatcaca    720

 ccccatcact tgctatggcc acgatggccc cttggatcac actctgtcac ttggtgtggc    780

 cacggtggcc actcggatca cactccatca cccactacgg ccacagcagt cactcggatc    840

 acatcccgtc acccactacg gccacagcag tcactcggat cacatcccgt cactcactac    900

 agccatggca gccactctga ttgcattccc gtcactcgct atgcccacgg cggccactca    960

 gatcacactc catcacttgc tatggccacg gcagccactc agatggcact ctgtcactca   1020

 ctatggccac ggcagccact tggatacttg gtcaataaaa taagaaggcc   atg cac    1076
                                                          Met His
                                                            1

 tgg ctc tgt gtc tcc tgc atc ttc act tgt ctg cct ggc tgg cgg cca     1124
 Trp Leu Cys Val Ser Cys Ile Phe Thr Cys Leu Pro Gly Trp Arg Pro
           5                  10                  15

 gcg gca cca gac caa gga ccc gcc gct att tcc ctg tgt tca ctg cct     1172
 Ala Ala Pro Asp Gln Gly Pro Ala Ala Ile Ser Leu Cys Ser Leu Pro
      20                  25                  30

 tcc tct tcg caa gga cac cga gag ccc ctg gct ctg ggc ctc cca tct     1220
 Ser Ser Ser Gln Gly His Arg Glu Pro Leu Ala Leu Gly Leu Pro Ser
  35                  40                  45                  50

 gcc ctt cct ccc gcc cat cgt cag cgt tta cga ggg tct gcc acg ctt     1268
 Ala Leu Pro Pro Ala His Arg Gln Arg Leu Arg Gly Ser Ala Thr Leu
                  55                  60                  65

 agg gtg gtg ccc cag ccc cca gtg ctg ggc agc tgc tct gca gaa gga     1316
 Arg Val Val Pro Gln Pro Pro Val Leu Gly Ser Cys Ser Ala Glu Gly
              70                  75                  80

 tgc ttg gga gat gga cgg gct ccc cct gcc gcc gga gcc tcc tgt ggc     1364
 Cys Leu Gly Asp Gly Arg Ala Pro Pro Ala Ala Gly Ala Ser Cys Gly
          85                  90                  95

 ccg agg cca tga ggg cagtgggtgg cagatgtggg gtgatgagtg gggcttcctg     1419
 Pro Arg Pro 
     100

 ccctccacag cccatgcgca gctgaccaga cggctgagct cagagaatat cccatgtgga   1479

 ggaaatctga gtgtcgaaga gaaaccacag cctatggaag ggacccctga gtgtcgaaga   1539

 gaaatcacag gcggcagtga ttgtggcttc cttcgtcgtt gtgtgtacgc cagcggtcac   1599

 ctgtctttgc accccactct gaagcctgca atgggacagc gattgcagct tccttcgtcg   1659

 ttgtgtagat gtgcacaggc cacatgggag acctccgtgg gctctccggc cttcactcag   1719

 ccagagataa ttcccctgcc caaaggcagc ccctctgcaa acaaagtctt attctttgaa   1779

 acaggaaccc tcaggggccg cctggggact ggtgccgact gtcaaaccca gcagatgggc   1839

 ttcatccagg cctcaactgt cagccgggac gaccccagat cacacgggcg tgggccgtgg   1899

 tcagccggga gcgtccacgt ggtcagccag cctgatgtgt tcggtgactc agccaaagct   1959

 taa                                                                 1962




      <210> 755
      <211> 456
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (1)..(456)

      <400> 755
  atg agg gcc agc agc ttc ttg atc gtg gtg gtg ttc ctc atc gct ggg      48
  Met Arg Ala Ser Ser Phe Leu Ile Val Val Val Phe Leu Ile Ala Gly
    1               5                  10                  15

 acg ctg gtt cta gag gca gct gtc acg gga gtt cct gtt aaa ggt caa       96
 Thr Leu Val Leu Glu Ala Ala Val Thr Gly Val Pro Val Lys Gly Gln
              20                  25                  30

 gac act gtc aaa ggc cgt gtt cca ttc aat gga caa gat ccc gtt aaa      144
 Asp Thr Val Lys Gly Arg Val Pro Phe Asn Gly Gln Asp Pro Val Lys
          35                  40                  45

 gga caa gtt tca gtt aaa ggt caa gat aaa gtc aaa gcg caa gag cca      192
 Gly Gln Val Ser Val Lys Gly Gln Asp Lys Val Lys Ala Gln Glu Pro
      50                  55                  60

 gtc aaa ggt cca gtc tcc act aag cct ggc tcc tgc ccc att atc ttg      240
 Val Lys Gly Pro Val Ser Thr Lys Pro Gly Ser Cys Pro Ile Ile Leu
  65                  70                  75                  80

 atc cgg tgc gcc atg ttg aat ccc cct aac cgc tgc ttg aaa gat act      288
 Ile Arg Cys Ala Met Leu Asn Pro Pro Asn Arg Cys Leu Lys Asp Thr
                  85                  90                  95

 gac tgc cca gga atc aag aag tgc tgt gaa ggc tct tgc ggg atg gcc      336
 Asp Cys Pro Gly Ile Lys Lys Cys Cys Glu Gly Ser Cys Gly Met Ala
             100                 105                 110

 tgt ttc gtt ccc cag tgt gac ctc aca agg caa ctt gca ttc tta act      384
 Cys Phe Val Pro Gln Cys Asp Leu Thr Arg Gln Leu Ala Phe Leu Thr
         115                 120                 125

 ctg tct cag ccc ctg aga acc ctg agc ttg ttg gat aac cca acc tgc      432
 Leu Ser Gln Pro Leu Arg Thr Leu Ser Leu Leu Asp Asn Pro Thr Cys
     130                 135                 140

 aaa aca cag ctc aca gat ttc tga                                      456
 Lys Thr Gln Leu Thr Asp Phe 
 145                 150





      <210> 756
      <211> 600
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (1)..(600)

      <400> 756
  atg aag ggc agc cct ttt ggc tgg cag ccc cac ttc tct att gcc acc      48
  Met Lys Gly Ser Pro Phe Gly Trp Gln Pro His Phe Ser Ile Ala Thr
    1               5                  10                  15

 ttc act cat gtc ttt agc acc cga ttt agg ctg atg ctg tgc agt gcc       96
 Phe Thr His Val Phe Ser Thr Arg Phe Arg Leu Met Leu Cys Ser Ala
              20                  25                  30

 tgc tgt gcc tgc tgt gaa ggg aac aag gac agg gct gtg agg ctg gaa      144
 Cys Cys Ala Cys Cys Glu Gly Asn Lys Asp Arg Ala Val Arg Leu Glu
          35                  40                  45

 gtc ctg ttc tac ttc agc tgc ata gat ctg att cat gat tgg tgc ctt      192
 Val Leu Phe Tyr Phe Ser Cys Ile Asp Leu Ile His Asp Trp Cys Leu
      50                  55                  60

 cca ctc cgc tct gtg ctc ctg aag agg ggt gtt gcc aag gtg ggg gac      240
 Pro Leu Arg Ser Val Leu Leu Lys Arg Gly Val Ala Lys Val Gly Asp
  65                  70                  75                  80

 ata gcc agt gtg ctg gaa ttt ggc aag agt ctt cga aga gac ctg ctc      288
 Ile Ala Ser Val Leu Glu Phe Gly Lys Ser Leu Arg Arg Asp Leu Leu
                  85                  90                  95

 agc ttt gct gtg gtt att gtg gac cca gtg acc ttc aag gac gtg gcc      336
 Ser Phe Ala Val Val Ile Val Asp Pro Val Thr Phe Lys Asp Val Ala
             100                 105                 110

 gtg gac ttc acc caa gaa gag tgg ggg cag ctg gac ctt gtt cag agg      384
 Val Asp Phe Thr Gln Glu Glu Trp Gly Gln Leu Asp Leu Val Gln Arg
         115                 120                 125

 acc ctg tac cgt gat gtg atg ctg gag acc tat ggt cac ctg ctc tct      432
 Thr Leu Tyr Arg Asp Val Met Leu Glu Thr Tyr Gly His Leu Leu Ser
     130                 135                 140

 gtg gga aat cag att gcc aag cct gag gtc atc tcc ctg ttg gag caa      480
 Val Gly Asn Gln Ile Ala Lys Pro Glu Val Ile Ser Leu Leu Glu Gln
 145                 150                 155                 160

 gga gaa gag ccg tgg tca gtg gag cag gca tgt cct caa cgc act tgt      528
 Gly Glu Glu Pro Trp Ser Val Glu Gln Ala Cys Pro Gln Arg Thr Cys
                 165                 170                 175

 cca gca aaa cca acc ccg aca atc ttt gaa gct cag caa ccc ttt gtg      576
 Pro Ala Lys Pro Thr Pro Thr Ile Phe Glu Ala Gln Gln Pro Phe Val
             180                 185                 190

 gag ata tat gat gct tgt aaa taa                                      600
 Glu Ile Tyr Asp Ala Cys Lys 
         195





      <210> 757
      <211> 735
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (1)..(735)

      <400> 757
  atg ggc ctg gac tct ggt aca gcc tgg ctc tgt agc atc tgg ctg gtt      48
  Met Gly Leu Asp Ser Gly Thr Ala Trp Leu Cys Ser Ile Trp Leu Val
    1               5                  10                  15

 ctg aag gac acg gtg aca gtc tgt gag ctc ctt ggc cat gcc cct ggc       96
 Leu Lys Asp Thr Val Thr Val Cys Glu Leu Leu Gly His Ala Pro Gly
              20                  25                  30

 tgg gag cct cac aca ggg atg cag ttc tac agc tta tct tat gaa ggg      144
 Trp Glu Pro His Thr Gly Met Gln Phe Tyr Ser Leu Ser Tyr Glu Gly
          35                  40                  45

 aca tgg atg aag ctg gaa acc atc att ctc agc aaa cta ttg caa gga      192
 Thr Trp Met Lys Leu Glu Thr Ile Ile Leu Ser Lys Leu Leu Gln Gly
      50                  55                  60

 caa aaa acc aga cac cgc atg ttc tct ctc ata gac aag ctg aac tca      240
 Gln Lys Thr Arg His Arg Met Phe Ser Leu Ile Asp Lys Leu Asn Ser
  65                  70                  75                  80

 aag cta gca agg gtg ggc agc caa cca gca acc tac ttc ccc aca gag      288
 Lys Leu Ala Arg Val Gly Ser Gln Pro Ala Thr Tyr Phe Pro Thr Glu
                  85                  90                  95

 aac ccc caa agg ctt agg aat ggg cag gac cag gta cct gtc aca gtg      336
 Asn Pro Gln Arg Leu Arg Asn Gly Gln Asp Gln Val Pro Val Thr Val
             100                 105                 110

 ggg gca aaa gag ggt ctg ctt aag aaa ctg ctg tgg act gaa ctg tgc      384
 Gly Ala Lys Glu Gly Leu Leu Lys Lys Leu Leu Trp Thr Glu Leu Cys
         115                 120                 125

 tcc ctt cca aac tca tac act gaa aac cca acc ccc aat ctg ttc tgg      432
 Ser Leu Pro Asn Ser Tyr Thr Glu Asn Pro Thr Pro Asn Leu Phe Trp
     130                 135                 140

 tgc aag agt cac aca gtt gaa gct ccg ccc atc ttt gtg ccc agt aat      480
 Cys Lys Ser His Thr Val Glu Ala Pro Pro Ile Phe Val Pro Ser Asn
 145                 150                 155                 160

 ccc gtg ctg tca cag aga tgg cca ctc ctg gcc ctg ggc ctg tct gcc      528
 Pro Val Leu Ser Gln Arg Trp Pro Leu Leu Ala Leu Gly Leu Ser Ala
                 165                 170                 175

 tta ccc cca cct cct ccc ttt gct ata ttc cag cca tgt gga gtg act      576
 Leu Pro Pro Pro Pro Pro Phe Ala Ile Phe Gln Pro Cys Gly Val Thr
             180                 185                 190

 gat agt tcc gtg agc cat atc atg ctg ctc tgt gtc tct gcg cct gtg      624
 Asp Ser Ser Val Ser His Ile Met Leu Leu Cys Val Ser Ala Pro Val
         195                 200                 205

 ccc gag ttc ctt tgg cca ttt tgg acc ctc ttc ctc cga ggc agc tcc      672
 Pro Glu Phe Leu Trp Pro Phe Trp Thr Leu Phe Leu Arg Gly Ser Ser
     210                 215                 220

 atc aac ccc aca atc ctt cct gcc aca gac gtc acc acc cca gct cag      720
 Ile Asn Pro Thr Ile Leu Pro Ala Thr Asp Val Thr Thr Pro Ala Gln
 225                 230                 235                 240

 aca gcg gct ccg tga                                                  735
 Thr Ala Ala Pro 






      <210> 758
      <211> 1218
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (909)..(1218)

      <400> 758
 atgagcttcg tctatttaag gagcaacaga aaggagacca gtaacgctgg agttaagaca     60

 atggaaaagt ggaataagat agagtcagat aggggaggag agtgccaagt gctggattat    120

 gatgcaccta gtattgccat cttgggttgc gtcaagaaac tgaccaccag gctagccaga    180

 aattggacag ataattcaga aaatgagaca gtcttgaaaa gctcgccaca cacctctggc    240

 tggatggaag gctatatgca tggacagcaa gaagagagtg aggcaaagct ctccatacaa    300

 cctttcctga aggcactcac agagaaaatt aaagaaaata aagaaaccac ttcccctggg    360

 gagatagtgg gggataaggg attgctgaaa tctgcccaga gccacctatc ctatgtcctt    420

 ctcctgaacc aaagcctaat cttcaggagg aatcgggaca tggaaggagc tggaagctat    480

 tatcttcagc agactaacac aggaacagaa aagcaaacac tgcatgttct cactgataag    540

 tgggagctga acaatgagaa cacacggaca cagggagggg aacaacacac actccacacc    600

 tacccgccta tacgctgtcc tggaatgctg ggtagagatt tggaaaacct catttctcct    660

 ctgccagtgg ctccctatga ggttctgcga atcgggaatg tgagaaaacc aatcaattgt    720

 ggcagtccta ccattgacaa ggactatata ctggctgcag aattcttcca gaaacaagaa    780

 aaacaaagtt ttgatgctca agaaacaaag caggcaggga aggaagccat tagggagaca    840

 attacagcaa aggttaatga atgttctgaa cagcaccgtg catacacagt ccctgccttc    900

 acaaagca tac cct cta cag ggg aga cat aaa gaa gat tcc aat cca gtg     950
          Met Leu Cys Glu Gly Arg Asp Cys Val Cys Thr Val Leu Phe
            1               5                  10

 tga cag aga cta tga cag agg tct ctc ctc caa att ctc atc agc tta      998
 Arg Thr Phe Ile Asn Leu Cys Cys Asn Cys Leu Pro Asn Gly Phe Leu
  15                  20                  25                  30

 tgg ctc aag aag cat gca gaa tga att cat tgc tgt cat cca caa tga     1046
 Pro Cys Leu Leu Cys Phe Leu Ser Ile Lys Thr Leu Phe Phe Leu Phe
                  35                  40                  45

 gga agc tga gac caa ctg gct att cat tct aca cac act gag tgc cca     1094
 Leu Glu Glu Phe Cys Ser Gln Tyr Ile Val Leu Val Asn Gly Arg Thr
              50                  55                  60

 cta tct ccc agg cac cac gct gag cac tgg aga agg aat caa agg cgt     1142
 Ala Thr Ile Asp Trp Phe Ser His Ile Pro Asp Ser Gln Asn Leu Ile
          65                  70                  75

 aga gtt tcg cat aaa gac aat gaa ggt aca gct aca gat agg tat cta     1190
 Gly Ser His Trp Gln Arg Arg Asn Glu Val Phe Gln Ile Ser Thr Gln
      80                  85                  90

 ctt ccc agc tgt cca tga aag agc ctg a                               1218
 His Ser Arg Thr Ala Tyr Arg Arg Val Gly Val Glu Cys Val Leu Phe 
  95                 100                 105                 110





      <210> 759
      <211> 459
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (97)..(459)

      <400> 759
 ccatttttcc agagtgtggg gagcagtgga cttgaggaag gagtctacca gccctttcca     60

 gactccccct caaccccaac cccaggaagc cgtaag  atg atc gct tgc agg gcc     114
                                          Met Ile Ala Cys Arg Ala
                                            1               5

 ctc acc gtc ctc acc tgg act cat gtg cga ata gat gag gga cat gtg      162
 Leu Thr Val Leu Thr Trp Thr His Val Arg Ile Asp Glu Gly His Val
              10                  15                  20

 cct gcc atg ttt gcc cag agc tcg gtg ttc agg gaa ctg att aca ggg      210
 Pro Ala Met Phe Ala Gln Ser Ser Val Phe Arg Glu Leu Ile Thr Gly
          25                  30                  35

 gtg gca aaa gcc aca ggg gcc aca cat ttg ctg agc tgc ttc cag gat      258
 Val Ala Lys Ala Thr Gly Ala Thr His Leu Leu Ser Cys Phe Gln Asp
      40                  45                  50

 gag gaa gta cag aca att ggt cag ata gaa ctg tgc ctc act aag caa      306
 Glu Glu Val Gln Thr Ile Gly Gln Ile Glu Leu Cys Leu Thr Lys Gln
  55                  60                  65                  70

 gac cag cag ctg caa aac tgc acc gag ccg ggg gag cag ccg tcc ccc      354
 Asp Gln Gln Leu Gln Asn Cys Thr Glu Pro Gly Glu Gln Pro Ser Pro
                  75                  80                  85

 aag cag gaa gtc tgg ctg gca aat ggg gcc gcc gag agc cgg ggt ctg      402
 Lys Gln Glu Val Trp Leu Ala Asn Gly Ala Ala Glu Ser Arg Gly Leu
              90                  95                 100

 aga gtc tgt gaa gat ggc cca gtc ttc tat ccc cca cct aaa aag acc      450
 Arg Val Cys Glu Asp Gly Pro Val Phe Tyr Pro Pro Pro Lys Lys Thr
         105                 110                 115

 aag cat tga                                                          459
 Lys His 
     120





      <210> 760
      <211> 1011
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (1)..(1011)

      <400> 760
  atg tgg cgc tct agg tgg gat gcc agc gtc ctg aag gcg gag gcc ctg      48
  Met Trp Arg Ser Arg Trp Asp Ala Ser Val Leu Lys Ala Glu Ala Leu
    1               5                  10                  15

 gcc ctc ctc ccc tgc ggc ctg ggc atg gca ttc tcc cag tcc cac gtg       96
 Ala Leu Leu Pro Cys Gly Leu Gly Met Ala Phe Ser Gln Ser His Val
              20                  25                  30

 atg gcc gct cgg cgg cac cag cac agc cgg ctc atc atc gag gtg gac      144
 Met Ala Ala Arg Arg His Gln His Ser Arg Leu Ile Ile Glu Val Asp
          35                  40                  45

 gag tac agc tcc aac ccc acc cag gcc ttc acc ttc tac aac atc aac      192
 Glu Tyr Ser Ser Asn Pro Thr Gln Ala Phe Thr Phe Tyr Asn Ile Asn
      50                  55                  60

 cag ggc cgc ttc cag cca ccg cat gtg cag ata ccc tgt gct tct ctt      240
 Gln Gly Arg Phe Gln Pro Pro His Val Gln Ile Pro Cys Ala Ser Leu
  65                  70                  75                  80

 gtg aaa gca gag atg ctt ttc caa aag gac tgg ggg att ctg ttg tct      288
 Val Lys Ala Glu Met Leu Phe Gln Lys Asp Trp Gly Ile Leu Leu Ser
                  85                  90                  95

 gcc cct cgg ggc att ggg ggt gct caa gca gtg agg ccc tgg gga gca      336
 Ala Pro Arg Gly Ile Gly Gly Ala Gln Ala Val Arg Pro Trp Gly Ala
             100                 105                 110

 cac aga ctc aag gcc ccc gtc aat gtg gac acc ctc tct aca gat gag      384
 His Arg Leu Lys Ala Pro Val Asn Val Asp Thr Leu Ser Thr Asp Glu
         115                 120                 125

 gat gct aag gtt ttg gaa ggt gct ggc tgt att gtc atc gtc tgg cca      432
 Asp Ala Lys Val Leu Glu Gly Ala Gly Cys Ile Val Ile Val Trp Pro
     130                 135                 140

 aat ctg ctg cca cca tca gtc cct ggg ctt gtt ggt ctt tat ttc aca      480
 Asn Leu Leu Pro Pro Ser Val Pro Gly Leu Val Gly Leu Tyr Phe Thr
 145                 150                 155                 160

 cat tct cct gaa act ccc cct ccc gtg ctg ctg tcc tgc gac ggc gga      528
 His Ser Pro Glu Thr Pro Pro Pro Val Leu Leu Ser Cys Asp Gly Gly
                 165                 170                 175

 cgt gcg ctg cac agc ccg ggc agt cgt cct cat cgc ccg acc aca ggc      576
 Arg Ala Leu His Ser Pro Gly Ser Arg Pro His Arg Pro Thr Thr Gly
             180                 185                 190

 ttt act cca tgc ggt ctc agt ggg ggc cat agc gcc cct aaa ggg gtg      624
 Phe Thr Pro Cys Gly Leu Ser Gly Gly His Ser Ala Pro Lys Gly Val
         195                 200                 205

 gac ccg gtg cct cac gat gcc ccc aaa cct cca ggc tac acc cgc ttc      672
 Asp Pro Val Pro His Asp Ala Pro Lys Pro Pro Gly Tyr Thr Arg Phe
     210                 215                 220

 gtc tgc gtc tct gat acc cac tcg agg acg gac ccc atc cag atg ccg      720
 Val Cys Val Ser Asp Thr His Ser Arg Thr Asp Pro Ile Gln Met Pro
 225                 230                 235                 240

 tac ggc gac gtg ctg atc cac gct ggg gac ttc act gag ctg ggg ctc      768
 Tyr Gly Asp Val Leu Ile His Ala Gly Asp Phe Thr Glu Leu Gly Leu
                 245                 250                 255

 ccg agc gag gtg aag aag ttc aac gag tgg ctg gat gag gag act gag      816
 Pro Ser Glu Val Lys Lys Phe Asn Glu Trp Leu Asp Glu Glu Thr Glu
             260                 265                 270

 gcc cag tgc gga gag gtg gtt tct gga ggt cac gca ggt ctc cag ggc      864
 Ala Gln Cys Gly Glu Val Val Ser Gly Gly His Ala Gly Leu Gln Gly
         275                 280                 285

 agg gat ctg gat cgt cag aag aag gat ttc aca cct ttc gga gtg tgc      912
 Arg Asp Leu Asp Arg Gln Lys Lys Asp Phe Thr Pro Phe Gly Val Cys
     290                 295                 300

 acg atg caa atg aag atc cga gag ctc gcg gaa ggc cgt ttg gag cta      960
 Thr Met Gln Met Lys Ile Arg Glu Leu Ala Glu Gly Arg Leu Glu Leu
 305                 310                 315                 320

 att ctg ggc tgg ttt gac agc cac gac act gaa ggg gaa gca tcg agc     1008
 Ile Leu Gly Trp Phe Asp Ser His Asp Thr Glu Gly Glu Ala Ser Ser
                 325                 330                 335

 tga                                                                 1011
 






      <210> 761
      <211> 1332
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (1)..(1332)

      <400> 761
  atg gcg ctg act ggg tac agc tgg ctg ctc ctc agt gcc aca ttc ctg      48
  Met Ala Leu Thr Gly Tyr Ser Trp Leu Leu Leu Ser Ala Thr Phe Leu
    1               5                  10                  15

 aat gtg ggg gcc gag atc tct atc acc ctg gag cct gcc cag ccg agc       96
 Asn Val Gly Ala Glu Ile Ser Ile Thr Leu Glu Pro Ala Gln Pro Ser
              20                  25                  30

 gaa ggg gac aac gtc acg ctg gtc gtc cat ggg ctt tcg ggg gaa ctg      144
 Glu Gly Asp Asn Val Thr Leu Val Val His Gly Leu Ser Gly Glu Leu
          35                  40                  45

 ctc gcc tac agc tgg tat gcg ggg ccc aca ctc agc gtg tca tac ctg      192
 Leu Ala Tyr Ser Trp Tyr Ala Gly Pro Thr Leu Ser Val Ser Tyr Leu
      50                  55                  60

 gtg gcc agc tac atc gtg agc aca ggc gat gag act cct ggc ccg gcc      240
 Val Ala Ser Tyr Ile Val Ser Thr Gly Asp Glu Thr Pro Gly Pro Ala
  65                  70                  75                  80

 cac acg ggg cgg gag gct gtg cgc ccc gat ggc agc ctg gac atc cag      288
 His Thr Gly Arg Glu Ala Val Arg Pro Asp Gly Ser Leu Asp Ile Gln
                  85                  90                  95

 ggc atc ctg ccc cgg cac tca ggc acc tac atc ctg cag acc ttc aac      336
 Gly Ile Leu Pro Arg His Ser Gly Thr Tyr Ile Leu Gln Thr Phe Asn
             100                 105                 110

 agg cag ttg cag acc gag gtg ggc tac gga cac gtg cag gtc cat gag      384
 Arg Gln Leu Gln Thr Glu Val Gly Tyr Gly His Val Gln Val His Glu
         115                 120                 125

 atc ctg gcc cag ccc aca gtc ttg gcc aac agc aca gcg ctg gtg gaa      432
 Ile Leu Ala Gln Pro Thr Val Leu Ala Asn Ser Thr Ala Leu Val Glu
     130                 135                 140

 cgt cga gac acc ctg cgc ctt atg tgc agc agc ccc agc ccc acc gcc      480
 Arg Arg Asp Thr Leu Arg Leu Met Cys Ser Ser Pro Ser Pro Thr Ala
 145                 150                 155                 160

 gag gtc cgc tgg ttc ttc aac ggt ggg gcc ctg ccc gtc gct ctc cgc      528
 Glu Val Arg Trp Phe Phe Asn Gly Gly Ala Leu Pro Val Ala Leu Arg
                 165                 170                 175

 ctg ggc ctg tcc cct gac ggc cgg gtg ctg gcc agg cat ggc atc cgc      576
 Leu Gly Leu Ser Pro Asp Gly Arg Val Leu Ala Arg His Gly Ile Arg
             180                 185                 190

 cgg gag gag gcc ggc gcc tat cag tgt gag gtg tgg aac ccg gtc agt      624
 Arg Glu Glu Ala Gly Ala Tyr Gln Cys Glu Val Trp Asn Pro Val Ser
         195                 200                 205

 gtc agc cgc agc gag ccc atc aac ctg acc gtg tac ttt ggc cca gag      672
 Val Ser Arg Ser Glu Pro Ile Asn Leu Thr Val Tyr Phe Gly Pro Glu
     210                 215                 220

 cgt gtg gcc atc ctc cag gat tcc acc acc cgc aca ggc tgc acc atc      720
 Arg Val Ala Ile Leu Gln Asp Ser Thr Thr Arg Thr Gly Cys Thr Ile
 225                 230                 235                 240

 aaa gtt gac ttc aac acg tcc ctc acc ctg tgg tgc gtg tcc agg tcc      768
 Lys Val Asp Phe Asn Thr Ser Leu Thr Leu Trp Cys Val Ser Arg Ser
                 245                 250                 255

 tgc cca gag ccc gag tat gtg tgg acc ttc aac ggg cag gcc cta aag      816
 Cys Pro Glu Pro Glu Tyr Val Trp Thr Phe Asn Gly Gln Ala Leu Lys
             260                 265                 270

 aac ggc caa gac cac ctc aac atc agc agc atg aca gcc gcc cag gag      864
 Asn Gly Gln Asp His Leu Asn Ile Ser Ser Met Thr Ala Ala Gln Glu
         275                 280                 285

 ggg acg tac aca tgt att gcg aag aac acc aag acc ctg cta tct gga      912
 Gly Thr Tyr Thr Cys Ile Ala Lys Asn Thr Lys Thr Leu Leu Ser Gly
     290                 295                 300

 tct gcc tca gtc gtg gtc aag ctc tct gct gca gca gtt gcc acg atg      960
 Ser Ala Ser Val Val Val Lys Leu Ser Ala Ala Ala Val Ala Thr Met
 305                 310                 315                 320

 atc gtg ccc gtg ccc acc aag cca acg gag ggc cag gac gta aca ctg     1008
 Ile Val Pro Val Pro Thr Lys Pro Thr Glu Gly Gln Asp Val Thr Leu
                 325                 330                 335

 acc gtg cag ggc tac ccc aag gac ctg ctg gtc tac gcc tgg tac cgc     1056
 Thr Val Gln Gly Tyr Pro Lys Asp Leu Leu Val Tyr Ala Trp Tyr Arg
             340                 345                 350

 ggg cct gcc tcc gag ccc aac cgg ctg ctc agc cag ctg ccg tca gga     1104
 Gly Pro Ala Ser Glu Pro Asn Arg Leu Leu Ser Gln Leu Pro Ser Gly
         355                 360                 365

 acc tgg att gca ggc ccc gcg cac aca ggc cgg gag gtg ggc ttc ccc     1152
 Thr Trp Ile Ala Gly Pro Ala His Thr Gly Arg Glu Val Gly Phe Pro
     370                 375                 380

 aac tgc tcg ctg ttg gtg cag aag ctg aac ctc aca gac act ggc cgc     1200
 Asn Cys Ser Leu Leu Val Gln Lys Leu Asn Leu Thr Asp Thr Gly Arg
 385                 390                 395                 400

 tac aca ctc aag acc gtc aca gtg cag ggc aag act gag aca ctg gaa     1248
 Tyr Thr Leu Lys Thr Val Thr Val Gln Gly Lys Thr Glu Thr Leu Glu
                 405                 410                 415

 gtg gag ctg cag gtg gcc ctc aac ctc cct ccc tcg cac aag gac caa     1296
 Val Glu Leu Gln Val Ala Leu Asn Leu Pro Pro Ser His Lys Asp Gln
             420                 425                 430

 cgc tac ctt cct gaa cct gaa cct ggc aca ggc tga                     1332
 Arg Tyr Leu Pro Glu Pro Glu Pro Gly Thr Gly 
         435                 440





      <210> 762
      <211> 3423
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (1)..(3423)

      <400> 762
  atg gtg tgc tgt ttc tac acc cgg cct ctg atc ctt ctc aca gct tcc      48
  Met Val Cys Cys Phe Tyr Thr Arg Pro Leu Ile Leu Leu Thr Ala Ser
    1               5                  10                  15

 acc acc acg gct ctg ggc caa gca cta atg att gat cgg aag atg tca       96
 Thr Thr Thr Ala Leu Gly Gln Ala Leu Met Ile Asp Arg Lys Met Ser
              20                  25                  30

 agt act cac acc agc tac aaa ctg gat gag gcg cag gct atc atg agt      144
 Ser Thr His Thr Ser Tyr Lys Leu Asp Glu Ala Gln Ala Ile Met Ser
          35                  40                  45

 gag ctc cgg acc atc aag aag gcc att tgc aca ggc gag aag gag agg      192
 Glu Leu Arg Thr Ile Lys Lys Ala Ile Cys Thr Gly Glu Lys Glu Arg
      50                  55                  60

 cgg gac ctg atg cat agc ctg gcc aag ctg acc gat agc ttc aag aac      240
 Arg Asp Leu Met His Ser Leu Ala Lys Leu Thr Asp Ser Phe Lys Asn
  65                  70                  75                  80

 agc tgc tcc gtt acc gac tct cta gtg gac ttc cct cac cat gta ggc      288
 Ser Cys Ser Val Thr Asp Ser Leu Val Asp Phe Pro His His Val Gly
                  85                  90                  95

 gtg cct ggc gat gct ggt gta ccc cag cag ttc tgc gat gcc ggc tcc      336
 Val Pro Gly Asp Ala Gly Val Pro Gln Gln Phe Cys Asp Ala Gly Ser
             100                 105                 110

 cag act gat atc atc ggg gag ttt gtc ttt gat gat aaa aca aga ctt      384
 Gln Thr Asp Ile Ile Gly Glu Phe Val Phe Asp Asp Lys Thr Arg Leu
         115                 120                 125

 gta gac cga gtc aga ctt aat tgg caa tat gaa gaa gcc aga aag aga      432
 Val Asp Arg Val Arg Leu Asn Trp Gln Tyr Glu Glu Ala Arg Lys Arg
     130                 135                 140

 gtc gcc aac atc cag cag cag ctg gcc cgg ctt gac aat gag tcc tgg      480
 Val Ala Asn Ile Gln Gln Gln Leu Ala Arg Leu Asp Asn Glu Ser Trp
 145                 150                 155                 160

 cca agc acg gcc gag gct gac agg gac cgg ctg cag ctc atc aag gag      528
 Pro Ser Thr Ala Glu Ala Asp Arg Asp Arg Leu Gln Leu Ile Lys Glu
                 165                 170                 175

 aag gag gcc ctg ctg cag gag ctt cag ctc atc att gca cag cgc cgc      576
 Lys Glu Ala Leu Leu Gln Glu Leu Gln Leu Ile Ile Ala Gln Arg Arg
             180                 185                 190

 tct gcg gga gat gtg gcc cgg ctg gag gag gag cgg gag cgc cta gag      624
 Ser Ala Gly Asp Val Ala Arg Leu Glu Glu Glu Arg Glu Arg Leu Glu
         195                 200                 205

 gag gag ctg cgg cgt gca cgg gcc acc tcc gca cag ggc gcc acg gag      672
 Glu Glu Leu Arg Arg Ala Arg Ala Thr Ser Ala Gln Gly Ala Thr Glu
     210                 215                 220

 agg att ctg ctt cag gaa aaa agg aat tgt cta ctt atg cag ctg gaa      720
 Arg Ile Leu Leu Gln Glu Lys Arg Asn Cys Leu Leu Met Gln Leu Glu
 225                 230                 235                 240

 gaa gcc acc cgc tta aca tcc tac ctc cag tcc cag tta aaa agc ctg      768
 Glu Ala Thr Arg Leu Thr Ser Tyr Leu Gln Ser Gln Leu Lys Ser Leu
                 245                 250                 255

 tgt gcc agc acc ctg acg gtg tcc tcg ggg agc agc cgc ggg tcc cta      816
 Cys Ala Ser Thr Leu Thr Val Ser Ser Gly Ser Ser Arg Gly Ser Leu
             260                 265                 270

 gcc tcc agc cgt ggg tct ctg gcc tcc agc cgg ggc tcc ctg agc tcg      864
 Ala Ser Ser Arg Gly Ser Leu Ala Ser Ser Arg Gly Ser Leu Ser Ser
         275                 280                 285

 gtc agc ttc acg gac atc tac ggc ctc ccg cag tac gag aag ccc gac      912
 Val Ser Phe Thr Asp Ile Tyr Gly Leu Pro Gln Tyr Glu Lys Pro Asp
     290                 295                 300

 gct gag ggc agc cag ctt cta cgc ttc gac ctc att ccc ttc gac tct      960
 Ala Glu Gly Ser Gln Leu Leu Arg Phe Asp Leu Ile Pro Phe Asp Ser
 305                 310                 315                 320

 ctg ggg cga gat gct ccc ttt tca gag ccc cca ggc ccc tcg ggc ttc     1008
 Leu Gly Arg Asp Ala Pro Phe Ser Glu Pro Pro Gly Pro Ser Gly Phe
                 325                 330                 335

 cac aag cag agg cgg tcc ctg gac acg ccc cag tcc ctg gca tcg ctg     1056
 His Lys Gln Arg Arg Ser Leu Asp Thr Pro Gln Ser Leu Ala Ser Leu
             340                 345                 350

 tcc tcc cgc tcc tcg ctg tcc tcg ctg tcg ccc cca agc tcg ccc ctg     1104
 Ser Ser Arg Ser Ser Leu Ser Ser Leu Ser Pro Pro Ser Ser Pro Leu
         355                 360                 365

 gac acg ccc ttc ctc cct gcc tca cgg gac tcg ccg ctg gcg cag ctg     1152
 Asp Thr Pro Phe Leu Pro Ala Ser Arg Asp Ser Pro Leu Ala Gln Leu
     370                 375                 380

 gcg gac agc tgt gag ggg cca ggc ctg ggc gcc cta gac aga ctg cgg     1200
 Ala Asp Ser Cys Glu Gly Pro Gly Leu Gly Ala Leu Asp Arg Leu Arg
 385                 390                 395                 400

 gca cac gcc tcg gct atg ggg gac gaa gac tta cca ggc atg gcg gcc     1248
 Ala His Ala Ser Ala Met Gly Asp Glu Asp Leu Pro Gly Met Ala Ala
                 405                 410                 415

 ctt cag cca cac ggg gtc ccc ggg gac ggg gaa ggg ccg cac gag cga     1296
 Leu Gln Pro His Gly Val Pro Gly Asp Gly Glu Gly Pro His Glu Arg
             420                 425                 430

 gga ccc cca cca gcc agc gct ccc gtg ggt gga aca gtg act ctt cga     1344
 Gly Pro Pro Pro Ala Ser Ala Pro Val Gly Gly Thr Val Thr Leu Arg
         435                 440                 445

 gaa gac agt gcc aag agg ttg gag agg agg gca cgc cgc atc tcc gca     1392
 Glu Asp Ser Ala Lys Arg Leu Glu Arg Arg Ala Arg Arg Ile Ser Ala
     450                 455                 460

 tgt ctg tcg gat tat tcg cta gcc agc gac agt ggg gtg ttt gaa cct     1440
 Cys Leu Ser Asp Tyr Ser Leu Ala Ser Asp Ser Gly Val Phe Glu Pro
 465                 470                 475                 480

 cta acc aaa agg aac gaa gat gcc gag gag cct gcc tac gga gac acg     1488
 Leu Thr Lys Arg Asn Glu Asp Ala Glu Glu Pro Ala Tyr Gly Asp Thr
                 485                 490                 495

 gcc agt aac gga gat ccc cag atc cac gtg gga ctc ctg cgc gac agt     1536
 Ala Ser Asn Gly Asp Pro Gln Ile His Val Gly Leu Leu Arg Asp Ser
             500                 505                 510

 ggc agc gag tgt ctc ctc gtg cac gtg ctg cag ctg aag aac ccg gcg     1584
 Gly Ser Glu Cys Leu Leu Val His Val Leu Gln Leu Lys Asn Pro Ala
         515                 520                 525

 ggg ctg gcg gtg aag gaa gac tgc aaa gtc cac atc cga gtc tat ttg     1632
 Gly Leu Ala Val Lys Glu Asp Cys Lys Val His Ile Arg Val Tyr Leu
     530                 535                 540

 ccc cca ctg gac tcg ggc acg ccc aac act tac tgc tcc aag gct ctg     1680
 Pro Pro Leu Asp Ser Gly Thr Pro Asn Thr Tyr Cys Ser Lys Ala Leu
 545                 550                 555                 560

 gag ttc caa gtg ccg ctg gtg ttt aac gaa gtg ttc aga atc ccc gtg     1728
 Glu Phe Gln Val Pro Leu Val Phe Asn Glu Val Phe Arg Ile Pro Val
                 565                 570                 575

 cat tcc agc gcg ttg aca ctg aag tca ctt cag tta tac gtg tgt tca     1776
 His Ser Ser Ala Leu Thr Leu Lys Ser Leu Gln Leu Tyr Val Cys Ser
             580                 585                 590

 gtg act ccg cag ctg cag gaa gaa ctg ctg ggc att gct cag att aac     1824
 Val Thr Pro Gln Leu Gln Glu Glu Leu Leu Gly Ile Ala Gln Ile Asn
         595                 600                 605

 ctg gct gac tat gac agt ttg agt gag atg cag ctg cgc tgg cat tcc     1872
 Leu Ala Asp Tyr Asp Ser Leu Ser Glu Met Gln Leu Arg Trp His Ser
     610                 615                 620

 gtg cag gtg ttc acc agc tct gaa cca tca agg acg cgg gag gct ggg     1920
 Val Gln Val Phe Thr Ser Ser Glu Pro Ser Arg Thr Arg Glu Ala Gly
 625                 630                 635                 640

 tgt gca gga gag agc tcc gcc cgg gac cct gca cac acc atc tcc atc     1968
 Cys Ala Gly Glu Ser Ser Ala Arg Asp Pro Ala His Thr Ile Ser Ile
                 645                 650                 655

 tcc ggc aag acg gat gcg gtg acg gtg ctc ctg gcc aga acc acg gca     2016
 Ser Gly Lys Thr Asp Ala Val Thr Val Leu Leu Ala Arg Thr Thr Ala
             660                 665                 670

 cag ctg cag gcg gtg gag agg gaa ctg gcc gag gag cgg gcc aag ctg     2064
 Gln Leu Gln Ala Val Glu Arg Glu Leu Ala Glu Glu Arg Ala Lys Leu
         675                 680                 685

 gag tac acg gag gag gag gtc ctg gag atg gag cgc aag gag gag cag     2112
 Glu Tyr Thr Glu Glu Glu Val Leu Glu Met Glu Arg Lys Glu Glu Gln
     690                 695                 700

 gcc gag gcc ata tcc gag cgg agt tgg caa gcg gac tcg gtg gat agc     2160
 Ala Glu Ala Ile Ser Glu Arg Ser Trp Gln Ala Asp Ser Val Asp Ser
 705                 710                 715                 720

 ggc tgt agc aac tgc acc cag acc agc cct ccg tac cca gag ccc tgt     2208
 Gly Cys Ser Asn Cys Thr Gln Thr Ser Pro Pro Tyr Pro Glu Pro Cys
                 725                 730                 735

 tgc atg ggt atc gac tcc atc ctg ggc cac cca ttt gct gct cag gca     2256
 Cys Met Gly Ile Asp Ser Ile Leu Gly His Pro Phe Ala Ala Gln Ala
             740                 745                 750

 ggg cct tac agc ccc gag aaa ttt cag ccc tcg cct ctt aag gtt gat     2304
 Gly Pro Tyr Ser Pro Glu Lys Phe Gln Pro Ser Pro Leu Lys Val Asp
         755                 760                 765

 aag gaa acc aac acg gaa gat ctc ttt ctg gaa gaa gca gcc agc ctc     2352
 Lys Glu Thr Asn Thr Glu Asp Leu Phe Leu Glu Glu Ala Ala Ser Leu
     770                 775                 780

 gtg aag gag cgg ccc agc cgc cgg gcc cga ggg tcg cct ttt gtt cgg     2400
 Val Lys Glu Arg Pro Ser Arg Arg Ala Arg Gly Ser Pro Phe Val Arg
 785                 790                 795                 800

 agt ggc acg att gtc cgt tcc cag aca ttc tcg cct gga gca cga agc     2448
 Ser Gly Thr Ile Val Arg Ser Gln Thr Phe Ser Pro Gly Ala Arg Ser
                 805                 810                 815

 cag tat gtt tgc aga gta agg cct ggg cgt cag aac ttc cgg aag cac     2496
 Gln Tyr Val Cys Arg Val Arg Pro Gly Arg Gln Asn Phe Arg Lys His
             820                 825                 830

 cca gat ggt tct agc atg tca cac aag gct gag aac ccc aag gtg ggt     2544
 Pro Asp Gly Ser Ser Met Ser His Lys Ala Glu Asn Pro Lys Val Gly
         835                 840                 845

 aga ggg aag atg cga gcc agt gtg gtc aat gaa gct gca ctt act ggc     2592
 Arg Gly Lys Met Arg Ala Ser Val Val Asn Glu Ala Ala Leu Thr Gly
     850                 855                 860

 gat gct tct gga tgc ttc gct gtt ctg tat gtt tgt atg aac gcc gtg     2640
 Asp Ala Ser Gly Cys Phe Ala Val Leu Tyr Val Cys Met Asn Ala Val
 865                 870                 875                 880

 cag ctt tat cgt agt gac agc gac agt tca acg ctg ccc cgg aag tcc     2688
 Gln Leu Tyr Arg Ser Asp Ser Asp Ser Ser Thr Leu Pro Arg Lys Ser
                 885                 890                 895

 ccc ttt gtc cga aat act ttg gaa aga cga acc ctt cgc tat aag cag     2736
 Pro Phe Val Arg Asn Thr Leu Glu Arg Arg Thr Leu Arg Tyr Lys Gln
             900                 905                 910

 tca tgc agg tct tcc ctg gct gag ctc atg gcc cgc acc tcc ctg gac     2784
 Ser Cys Arg Ser Ser Leu Ala Glu Leu Met Ala Arg Thr Ser Leu Asp
         915                 920                 925

 ttg gag ctg gat ctc cag gcg tcg aga aca cgg cag agg cag ctg aat     2832
 Leu Glu Leu Asp Leu Gln Ala Ser Arg Thr Arg Gln Arg Gln Leu Asn
     930                 935                 940

 gag gag ctc tgc gcc ctc cgt gag ctg cgg cag cgg ttg gag gac gcc     2880
 Glu Glu Leu Cys Ala Leu Arg Glu Leu Arg Gln Arg Leu Glu Asp Ala
 945                 950                 955                 960

 cag ctc cgt ggc cag act gac ctc cca ccc tgg gtg ctt cgg gac gag     2928
 Gln Leu Arg Gly Gln Thr Asp Leu Pro Pro Trp Val Leu Arg Asp Glu
                 965                 970                 975

 cgg ctc cgt ggc ctg ctg cgg gag gcc gag cgg cag aca aga cag acc     2976
 Arg Leu Arg Gly Leu Leu Arg Glu Ala Glu Arg Gln Thr Arg Gln Thr
             980                 985                 990

 aaa ctt gac tac cgt cat gag cag gcg gct gag aag atg ctg aag aag     3024
 Lys Leu Asp Tyr Arg His Glu Gln Ala Ala Glu Lys Met Leu Lys Lys
         995                1000                1005

 gcc tcc aag gag atc tac cag ctg cgt ggg cag agc cac aaa gag ccc     3072
 Ala Ser Lys Glu Ile Tyr Gln Leu Arg Gly Gln Ser His Lys Glu Pro
    1010                1015                1020

 atc caa gtg cag acc ttt agt ggt tca atc gtg act cgg aag cat gtg     3120
 Ile Gln Val Gln Thr Phe Ser Gly Ser Ile Val Thr Arg Lys His Val
1025                1030                1035                1040

 tgt gtt gca gag ctc aat gca gcc atg aca agg aaa gaa aag aca aag     3168
 Cys Val Ala Glu Leu Asn Ala Ala Met Thr Arg Lys Glu Lys Thr Lys
                1045                1050                1055

 gaa ggc cag aga gcc gcg cag ttc tct gca ggt gca gat gca ggc agt     3216
 Glu Gly Gln Arg Ala Ala Gln Phe Ser Ala Gly Ala Asp Ala Gly Ser
            1060                1065                1070

 gga ggt ggc ctg agc agg cag aag gac acc aag cgc cct atg ttg ctt     3264
 Gly Gly Gly Leu Ser Arg Gln Lys Asp Thr Lys Arg Pro Met Leu Leu
        1075                1080                1085

 gtc att cat gac gtg gtc ttg gag ctt ctg act agt tca gac tgc cac     3312
 Val Ile His Asp Val Val Leu Glu Leu Leu Thr Ser Ser Asp Cys His
    1090                1095                1100

 gcc aac ccc aga aaa tac ccc aca tgc cag aaa aac cct caa ccc aaa     3360
 Ala Asn Pro Arg Lys Tyr Pro Thr Cys Gln Lys Asn Pro Gln Pro Lys
1105                1110                1115                1120

 gga gca gga gat ttc ggt agc gtt tta act tta tct cag aat ctg aaa     3408
 Gly Ala Gly Asp Phe Gly Ser Val Leu Thr Leu Ser Gln Asn Leu Lys
                1125                1130                1135

 gcg gaa ggg ctg tga                                                 3423
 Ala Glu Gly Leu 
            1140





      <210> 763
      <211> 1194
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (1)..(1194)

      <400> 763
  atg gtt gaa cta gtt tac agt ccc att aac tgt gta aaa gtg ttc cta      48
  Met Val Glu Leu Val Tyr Ser Pro Ile Asn Cys Val Lys Val Phe Leu
    1               5                  10                  15

 ttt ctc cac atc ctc tcc agc acc tgt tca tct cac tgg gga gtg tcg       96
 Phe Leu His Ile Leu Ser Ser Thr Cys Ser Ser His Trp Gly Val Ser
              20                  25                  30

 gac agt ggg tgc agg aca gtg ggt gca gca cac cga tca caa tta gat      144
 Asp Ser Gly Cys Arg Thr Val Gly Ala Ala His Arg Ser Gln Leu Asp
          35                  40                  45

 gaa tgg cta act aaa ata acc aat gca gag aag tcc tta aaa gac ctg      192
 Glu Trp Leu Thr Lys Ile Thr Asn Ala Glu Lys Ser Leu Lys Asp Leu
      50                  55                  60

 atg gag ctg aaa acc acg gca cga gaa cta cgt gac gaa tgc aca agc      240
 Met Glu Leu Lys Thr Thr Ala Arg Glu Leu Arg Asp Glu Cys Thr Ser
  65                  70                  75                  80

 ctc agg agc caa ttc aat caa ctg gaa gaa agg gta tca gtg atg gaa      288
 Leu Arg Ser Gln Phe Asn Gln Leu Glu Glu Arg Val Ser Val Met Glu
                  85                  90                  95

 gat caa atg aat gaa atg aag cga gaa gag aag ttt aga gaa aaa aga      336
 Asp Gln Met Asn Glu Met Lys Arg Glu Glu Lys Phe Arg Glu Lys Arg
             100                 105                 110

 ata aaa aga aac aaa caa agc ctc caa gaa ata tgg gac tat gtg aaa      384
 Ile Lys Arg Asn Lys Gln Ser Leu Gln Glu Ile Trp Asp Tyr Val Lys
         115                 120                 125

 aga cca aat cta cgt ctg att ggt gta cct gaa agt gac ggg gag aat      432
 Arg Pro Asn Leu Arg Leu Ile Gly Val Pro Glu Ser Asp Gly Glu Asn
     130                 135                 140

 gga acc aag ttg gaa aac act ctg cag gat att atc cag gag aac ttc      480
 Gly Thr Lys Leu Glu Asn Thr Leu Gln Asp Ile Ile Gln Glu Asn Phe
 145                 150                 155                 160

 ccc aat caa gca agg cag gcc aac att caa att cag aaa ata cag aga      528
 Pro Asn Gln Ala Arg Gln Ala Asn Ile Gln Ile Gln Lys Ile Gln Arg
                 165                 170                 175

 acg cca caa aga tac tcc tcg aga aga gca act cca aga cac ata att      576
 Thr Pro Gln Arg Tyr Ser Ser Arg Arg Ala Thr Pro Arg His Ile Ile
             180                 185                 190

 gtc agt ttc acc aaa gtt gaa atg aag gaa aaa aag ggt aat cct gga      624
 Val Ser Phe Thr Lys Val Glu Met Lys Glu Lys Lys Gly Asn Pro Gly
         195                 200                 205

 gtt tcc cta gag ctg cgg ctt acc aag cct ggc tgt aca ttg gtg cag      672
 Val Ser Leu Glu Leu Arg Leu Thr Lys Pro Gly Cys Thr Leu Val Gln
     210                 215                 220

 cct gag gag gta ctc agt gaa tcg caa tca ctg aga tgg gac cca gga      720
 Pro Glu Glu Val Leu Ser Glu Ser Gln Ser Leu Arg Trp Asp Pro Gly
 225                 230                 235                 240

 agc aga act ttt caa agt gcc aca act ggc gct gat gtg cag ggc tac      768
 Ser Arg Thr Phe Gln Ser Ala Thr Thr Gly Ala Asp Val Gln Gly Tyr
                 245                 250                 255

 atg gct cta gaa cta gtc ctt gct gga aag gcc tgg gat aaa gca tcc      816
 Met Ala Leu Glu Leu Val Leu Ala Gly Lys Ala Trp Asp Lys Ala Ser
             260                 265                 270

 ctt ggc gga ctc cgc tct gct gcg ggc cgg aaa ctt tcc tcc ccg cct      864
 Leu Gly Gly Leu Arg Ser Ala Ala Gly Arg Lys Leu Ser Ser Pro Pro
         275                 280                 285

 agt ctg cgc tgg gta ctg ttg tta ttc gtg act gtc ccc tct cgc ggg      912
 Ser Leu Arg Trp Val Leu Leu Leu Phe Val Thr Val Pro Ser Arg Gly
     290                 295                 300

 gag ctc gga cac ctt gga cag gtc ttc gtc ggc ggg agc gcg ccc tgc      960
 Glu Leu Gly His Leu Gly Gln Val Phe Val Gly Gly Ser Ala Pro Cys
 305                 310                 315                 320

 ctg gcc caa cgc gag gta aag gag gca ctg ggg cag ccg gac tcg gcc     1008
 Leu Ala Gln Arg Glu Val Lys Glu Ala Leu Gly Gln Pro Asp Ser Ala
                 325                 330                 335

 gct gcc agg gtg cag agc ccg cgc ctc ggc cgc tgg acg ccg gcc gcc     1056
 Ala Ala Arg Val Gln Ser Pro Arg Leu Gly Arg Trp Thr Pro Ala Ala
             340                 345                 350

 tcc ccg cct ctc cgg acc cga cac gtg cga gcc tcc cac gga cgc ggc     1104
 Ser Pro Pro Leu Arg Thr Arg His Val Arg Ala Ser His Gly Arg Gly
         355                 360                 365

 ccc tcc cag acc acc cca cgt cct ccc cct gca cgg cca cag cca ccc     1152
 Pro Ser Gln Thr Thr Pro Arg Pro Pro Pro Ala Arg Pro Gln Pro Pro
     370                 375                 380

 cat agg ttg gac acc cgg ggc tcg cgg gtc ctg att ggc tga             1194
 His Arg Leu Asp Thr Arg Gly Ser Arg Val Leu Ile Gly 
 385                 390                 395





      <210> 764
      <211> 546
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (422)..(546)

      <400> 764
 atgctggaga ttctggggtc cagtcagttc agagatgctg aagctgtcag atgtggcacc     60

 agagccctag gttctcaagc aaggagctat gtggcagcag atgttgtgta cagtggctct    120

 tggaactgtt tctgtagaca aaatgagctg ctgctgaaga caagcgagcc agccacctgg    180

 caccgcccta ccagagggac gagggatgtg aattcccagc atgctctgca gcagcatgga    240

 cagccaggga cactcagagg ccagaaggaa gatgttcctg cagctgccgg cagttggtat    300

 aggagcgtcc aggggccgca tgtgattctg atggatctgg ctaggtcaag taggaagttt    360

 ctgagcttta caaaagtgaa aactgtccta actgataaga agagtacagg ggacaagaac    420

 a    tag aga ccc tgg gaa cgc ctt ccc caa cac agc aca ctc aca cct     466
      Met Phe Leu Ser Pro Val Leu Phe Leu Ser Val Arg Thr Val Phe
        1               5                  10                  15

 tta cgg caa aaa ggg tgc ttc att cca gat tgc tgc tga atc tga tac      514
 Thr Phe Val Lys Leu Arg Asn Phe Leu Leu Asp Leu Ala Arg Ser Ile
                  20                  25                  30

 ctg gat cga ctc caa ata caa atg tga tgt ga                           546
 Arg Ile Thr Cys Gly Pro Trp Thr Leu Leu Tyr Gln Leu Pro Ala Ala 
              35                  40                  45





      <210> 765
      <211> 441
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (1)..(441)

      <400> 765
  atg agc act ctc tat gaa att ttt cca tct tct gtg cct ggc ttc tat      48
  Met Ser Thr Leu Tyr Glu Ile Phe Pro Ser Ser Val Pro Gly Phe Tyr
    1               5                  10                  15

 gtt gtt ttg ggg gtc tcc gca tta ggg att atg atg ttt ggg att gtg       96
 Val Val Leu Gly Val Ser Ala Leu Gly Ile Met Met Phe Gly Ile Val
              20                  25                  30

 tct ttt ggg att ata atc cca acc cag tgg aaa gaa gaa cag atg agt      144
 Ser Phe Gly Ile Ile Ile Pro Thr Gln Trp Lys Glu Glu Gln Met Ser
          35                  40                  45

 tcc att ggt ggt gcc aac ctt gac tta caa att gaa cag tgt atc tac      192
 Ser Ile Gly Gly Ala Asn Leu Asp Leu Gln Ile Glu Gln Cys Ile Tyr
      50                  55                  60

 aaa atg aaa agt gat tgc acc tat gac aca aat gtc aag agg aac tgg      240
 Lys Met Lys Ser Asp Cys Thr Tyr Asp Thr Asn Val Lys Arg Asn Trp
  65                  70                  75                  80

 gag aag ctt ctg ccg gca gct tgt gcc att gtt gcc att gaa aac tct      288
 Glu Lys Leu Leu Pro Ala Ala Cys Ala Ile Val Ala Ile Glu Asn Ser
                  85                  90                  95

 ggt gat gtc agt gtt ata ccc tcc agg aat cct ggc cag caa gct gtg      336
 Gly Asp Val Ser Val Ile Pro Ser Arg Asn Pro Gly Gln Gln Ala Val
             100                 105                 110

 atg atg ttt gtt gct tcc act gga gcc act cct att act ggc tgc ttc      384
 Met Met Phe Val Ala Ser Thr Gly Ala Thr Pro Ile Thr Gly Cys Phe
         115                 120                 125

 act ctt gga atc ttc act acc aag atc caa gaa gcc aca tct gct ggt      432
 Thr Leu Gly Ile Phe Thr Thr Lys Ile Gln Glu Ala Thr Ser Ala Gly
     130                 135                 140

 gat tac tga                                                          441
 Asp Tyr 
 145





      <210> 766
      <211> 1137
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (1)..(1137)

      <400> 766
  atg act cag ata agt aac ata aag cag cct ttt gcc atg cag cac agg      48
  Met Thr Gln Ile Ser Asn Ile Lys Gln Pro Phe Ala Met Gln His Arg
    1               5                  10                  15

 ttc ttc att tcc ctt ttg cac tgg acc ctg caa att gtg tat cca gca       96
 Phe Phe Ile Ser Leu Leu His Trp Thr Leu Gln Ile Val Tyr Pro Ala
              20                  25                  30

 ctg ttc cta gga ctt tgt gaa cgg gga aga aat ggg agg tgt gat caa      144
 Leu Phe Leu Gly Leu Cys Glu Arg Gly Arg Asn Gly Arg Cys Asp Gln
          35                  40                  45

 gta cca gaa ggc tct gtg ctg tct ctg ctg gtc tgg gtg gtt cct gga      192
 Val Pro Glu Gly Ser Val Leu Ser Leu Leu Val Trp Val Val Pro Gly
      50                  55                  60

 ctg gcg ttc cct gag gtt gca cct ggc acg tgt ggc acc agc tat gtt      240
 Leu Ala Phe Pro Glu Val Ala Pro Gly Thr Cys Gly Thr Ser Tyr Val
  65                  70                  75                  80

 cct gat gct gga ctc cat ggt cct gaa gtg gaa tca aaa ctg ggg ctt      288
 Pro Asp Ala Gly Leu His Gly Pro Glu Val Glu Ser Lys Leu Gly Leu
                  85                  90                  95

 gac ccc gga tcg atg act ggg act cag cct acg cgg acg cca gcg cag      336
 Asp Pro Gly Ser Met Thr Gly Thr Gln Pro Thr Arg Thr Pro Ala Gln
             100                 105                 110

 cct gcg gcg gcc gag cca cct gcc ctc aca ggg cct ggc cgg gtg cat      384
 Pro Ala Ala Ala Glu Pro Pro Ala Leu Thr Gly Pro Gly Arg Val His
         115                 120                 125

 cag gaa cag gcg gtc tta gcg tgt gga ttt ctg ggc att tac cac ttg      432
 Gln Glu Gln Ala Val Leu Ala Cys Gly Phe Leu Gly Ile Tyr His Leu
     130                 135                 140

 ggg gca gca tct gca ctt tgc aga cat ggc aaa aaa ctt gtg aag gat      480
 Gly Ala Ala Ser Ala Leu Cys Arg His Gly Lys Lys Leu Val Lys Asp
 145                 150                 155                 160

 gtc aaa gcc ttc gct ggg gcg tct gcg gga tcg ttg gtt gct tct gtt      528
 Val Lys Ala Phe Ala Gly Ala Ser Ala Gly Ser Leu Val Ala Ser Val
                 165                 170                 175

 ctg cta aca gca cca gaa aaa ata gag gaa tgt aac caa ttt acc tac      576
 Leu Leu Thr Ala Pro Glu Lys Ile Glu Glu Cys Asn Gln Phe Thr Tyr
             180                 185                 190

 aag ttt gcc gaa gaa atc aga agg cag tct ttc ggg gca gta acg ccc      624
 Lys Phe Ala Glu Glu Ile Arg Arg Gln Ser Phe Gly Ala Val Thr Pro
         195                 200                 205

 ggt tat gac ttc atg gcc cga cta aga agt ggg atg gag tcg att ctt      672
 Gly Tyr Asp Phe Met Ala Arg Leu Arg Ser Gly Met Glu Ser Ile Leu
     210                 215                 220

 cct ccc agc gct cac gag ctg gcc cag aac cga ctg cac gta tcc atc      720
 Pro Pro Ser Ala His Glu Leu Ala Gln Asn Arg Leu His Val Ser Ile
 225                 230                 235                 240

 acc aac gcc aaa acc aga gaa aat cac tta gtc tcc act ttt tcc tcc      768
 Thr Asn Ala Lys Thr Arg Glu Asn His Leu Val Ser Thr Phe Ser Ser
                 245                 250                 255

 agg gag gac ctc att aag gtc ctc cta gcc agc agt ttt gtg ccc att      816
 Arg Glu Asp Leu Ile Lys Val Leu Leu Ala Ser Ser Phe Val Pro Ile
             260                 265                 270

 tat gca gga ctg aag cta gtg gaa tac aaa ggg cag aag tgg gtg gac      864
 Tyr Ala Gly Leu Lys Leu Val Glu Tyr Lys Gly Gln Lys Trp Val Asp
         275                 280                 285

 gga ggc ctc acc aac gct ctt ccc atc ctg ccc gtc ggc cgg aca gta      912
 Gly Gly Leu Thr Asn Ala Leu Pro Ile Leu Pro Val Gly Arg Thr Val
     290                 295                 300

 acc atc tcc ccc ttc agt gga cga ctg gac atc tcc ccg cag gac aaa      960
 Thr Ile Ser Pro Phe Ser Gly Arg Leu Asp Ile Ser Pro Gln Asp Lys
 305                 310                 315                 320

 ggg cag cta gat ctg tat gtt aat atc gcc aag cag gat atc atg ttg     1008
 Gly Gln Leu Asp Leu Tyr Val Asn Ile Ala Lys Gln Asp Ile Met Leu
                 325                 330                 335

 tcc ctg gca aac ctg gtg aga ctc aac caa gcc ctt ttt ccc cca agc     1056
 Ser Leu Ala Asn Leu Val Arg Leu Asn Gln Ala Leu Phe Pro Pro Ser
             340                 345                 350

 aag agg aaa atg gaa tct ttg tat cag tgt ggt ttt gat gac act gtt     1104
 Lys Arg Lys Met Glu Ser Leu Tyr Gln Cys Gly Phe Asp Asp Thr Val
         355                 360                 365

 aag ttt tta ctt aaa gaa aat tgg ttt gaa taa                         1137
 Lys Phe Leu Leu Lys Glu Asn Trp Phe Glu 
     370                 375





      <210> 767
      <211> 501
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (1)..(501)

      <400> 767
  atg agc aac cag gtg ctc tgc tgt gtg gtc ctt tgt ctc ctg gga gca      48
  Met Ser Asn Gln Val Leu Cys Cys Val Val Leu Cys Leu Leu Gly Ala
    1               5                  10                  15

 aac acc gtg gat ggt gga atc act cag tcc cca aag tac ctg ttc aga       96
 Asn Thr Val Asp Gly Gly Ile Thr Gln Ser Pro Lys Tyr Leu Phe Arg
              20                  25                  30

 aag gaa gga cag aat gtg acc ctg agt tgt gaa cag aat ttg aac cac      144
 Lys Glu Gly Gln Asn Val Thr Leu Ser Cys Glu Gln Asn Leu Asn His
          35                  40                  45

 gat gcc atg tac tgg tac cga cag gac cca ggg caa ggg ctg aga ttg      192
 Asp Ala Met Tyr Trp Tyr Arg Gln Asp Pro Gly Gln Gly Leu Arg Leu
      50                  55                  60

 atc tac tac tca cag ata gta aat gac ttt cag aaa gga gat ata gct      240
 Ile Tyr Tyr Ser Gln Ile Val Asn Asp Phe Gln Lys Gly Asp Ile Ala
  65                  70                  75                  80

 gaa ggg ctt agg ttg gtg gaa gcc gtg gtt ggg gga att gtt ggt aaa      288
 Glu Gly Leu Arg Leu Val Glu Ala Val Val Gly Gly Ile Val Gly Lys
                  85                  90                  95

 att gct tgg ata ggg atg gac ctg gaa aag aag caa agt acg ctg gaa      336
 Ile Ala Trp Ile Gly Met Asp Leu Glu Lys Lys Gln Ser Thr Leu Glu
             100                 105                 110

 gaa ata tct aga acg gca gat gat gtg att ttg gca agc gtg tca cat      384
 Glu Ile Ser Arg Thr Ala Asp Asp Val Ile Leu Ala Ser Val Ser His
         115                 120                 125

 gtt gat ttc tgt ttt gcc ggt gaa tgc atc agg cct gag cct gta ctc      432
 Val Asp Phe Cys Phe Ala Gly Glu Cys Ile Arg Pro Glu Pro Val Leu
     130                 135                 140

 agc aag gcc aga cgg atc ctc tgc tcc aaa ctt gcc ctg gct gcc tac      480
 Ser Lys Ala Arg Arg Ile Leu Cys Ser Lys Leu Ala Leu Ala Ala Tyr
 145                 150                 155                 160

 ctc cct cag cat gaa agc tga                                          501
 Leu Pro Gln His Glu Ser 
                 165





      <210> 768
      <211> 2679
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (1)..(2679)

      <400> 768
  atg gcc aat cac tgt atc ttc ctg aac agc atc tct gct ttg gta ctg      48
  Met Ala Asn His Cys Ile Phe Leu Asn Ser Ile Ser Ala Leu Val Leu
    1               5                  10                  15

 ctg ctg tac aca aag cac agt gcc ggc att tgc aat ggc ctc cag ctg       96
 Leu Leu Tyr Thr Lys His Ser Ala Gly Ile Cys Asn Gly Leu Gln Leu
              20                  25                  30

 ctt ccg ctc gtg gtg gaa ggg gag cca gtg tgt gaa gat cac aca gtc      144
 Leu Pro Leu Val Val Glu Gly Glu Pro Val Cys Glu Asp His Thr Val
          35                  40                  45

 aga aag ggt gga ggt ggg gga gat aga cag ata gtt gac att gtt aac      192
 Arg Lys Gly Gly Gly Gly Gly Asp Arg Gln Ile Val Asp Ile Val Asn
      50                  55                  60

 agt cag ctg agg gca gga tac gat atc tta atc atg att acc ttt att      240
 Ser Gln Leu Arg Ala Gly Tyr Asp Ile Leu Ile Met Ile Thr Phe Ile
  65                  70                  75                  80

 tgt atc aca cac tac aac ctg atg ctt cga aaa ccc aag ttt cct gat      288
 Cys Ile Thr His Tyr Asn Leu Met Leu Arg Lys Pro Lys Phe Pro Asp
                  85                  90                  95

 cgt tgc tat gac aca ccc agg att aag cga gcg tat gcg aga agc gct      336
 Arg Cys Tyr Asp Thr Pro Arg Ile Lys Arg Ala Tyr Ala Arg Ser Ala
             100                 105                 110

 ctg caa acc gcc agg caa acg gca acg aag aag ctg cct cag aaa caa      384
 Leu Gln Thr Ala Arg Gln Thr Ala Thr Lys Lys Leu Pro Gln Lys Gln
         115                 120                 125

 tac ctg aat gag gcg ggg gcc gaa gaa ctt gct gac aat ggg cac cgg      432
 Tyr Leu Asn Glu Ala Gly Ala Glu Glu Leu Ala Asp Asn Gly His Arg
     130                 135                 140

 tca atg ctc ggg cac gtg gat gga gct gga agc cgt tat cct tgg cag      480
 Ser Met Leu Gly His Val Asp Gly Ala Gly Ser Arg Tyr Pro Trp Gln
 145                 150                 155                 160

 act gat gca gga aca gaa aac caa ata ctg cat gtt ctc aag tgg gag      528
 Thr Asp Ala Gly Thr Glu Asn Gln Ile Leu His Val Leu Lys Trp Glu
                 165                 170                 175

 ctg aat gat gag aac aca tgg aca cat ggt ggg aac aac acc cac tgt      576
 Leu Asn Asp Glu Asn Thr Trp Thr His Gly Gly Asn Asn Thr His Cys
             180                 185                 190

 ggc ctg tca gag ggc aac tgt gac aca atg gta ttt gtg tat cta aac      624
 Gly Leu Ser Glu Gly Asn Cys Asp Thr Met Val Phe Val Tyr Leu Asn
         195                 200                 205

 ata gaa aag tgt ctc aat gag atc ttg gag tca gca gat gca ccc tta      672
 Ile Glu Lys Cys Leu Asn Glu Ile Leu Glu Ser Ala Asp Ala Pro Leu
     210                 215                 220

 gaa gtc act gaa gga ttc att cag tca att tcc ctg tca gtt cca tgg      720
 Glu Val Thr Glu Gly Phe Ile Gln Ser Ile Ser Leu Ser Val Pro Trp
 225                 230                 235                 240

 ggc tct tta ctg cag gat aat tgt gca ctg gaa gtg aga gga tta gaa      768
 Gly Ser Leu Leu Gln Asp Asn Cys Ala Leu Glu Val Arg Gly Leu Glu
                 245                 250                 255

 atg gtc ttc cgg cct aga cct cgc cca gca act ggt tct gag cct atg      816
 Met Val Phe Arg Pro Arg Pro Arg Pro Ala Thr Gly Ser Glu Pro Met
             260                 265                 270

 tat tgg tca agt ttt atg acc agc agt atg caa ttg gca aaa gaa tgt      864
 Tyr Trp Ser Ser Phe Met Thr Ser Ser Met Gln Leu Ala Lys Glu Cys
         275                 280                 285

 ctt agc cag aaa cta aca gat gaa caa gga gaa gga tcc cag cct ttt      912
 Leu Ser Gln Lys Leu Thr Asp Glu Gln Gly Glu Gly Ser Gln Pro Phe
     290                 295                 300

 gaa gga ctt gaa aag ttt gct gaa acc att gaa aca gtg cag att gga      960
 Glu Gly Leu Glu Lys Phe Ala Glu Thr Ile Glu Thr Val Gln Ile Gly
 305                 310                 315                 320

 cgg tta att ggt agg ttg gag ttg agt ctc acg ttg aaa cag aat gaa     1008
 Arg Leu Ile Gly Arg Leu Glu Leu Ser Leu Thr Leu Lys Gln Asn Glu
                 325                 330                 335

 gtg ctt cct gga gct aag aaa ctt gcc aca gta gag atg atg gca tcc     1056
 Val Leu Pro Gly Ala Lys Lys Leu Ala Thr Val Glu Met Met Ala Ser
             340                 345                 350

 cac atg tat act tca tat aat aaa cat att agt ctg cac aag gct ttc     1104
 His Met Tyr Thr Ser Tyr Asn Lys His Ile Ser Leu His Lys Ala Phe
         355                 360                 365

 act gaa gtg ttt cta gat gat tca cat agt cct gca aat tgt cgg ata     1152
 Thr Glu Val Phe Leu Asp Asp Ser His Ser Pro Ala Asn Cys Arg Ile
     370                 375                 380

 tca gta caa gtt gcc aca cca gca tta aac ctt tct gtt cgc ttc cca     1200
 Ser Val Gln Val Ala Thr Pro Ala Leu Asn Leu Ser Val Arg Phe Pro
 385                 390                 395                 400

 ata cct gat ctt cga tct gat caa gaa aga gga cca tgg ttt aag aag     1248
 Ile Pro Asp Leu Arg Ser Asp Gln Glu Arg Gly Pro Trp Phe Lys Lys
                 405                 410                 415

 tca ctt cag aag gag atc ctt tat tta gcc ttc aca gat cta gaa ttt     1296
 Ser Leu Gln Lys Glu Ile Leu Tyr Leu Ala Phe Thr Asp Leu Glu Phe
             420                 425                 430

 aag act gaa ttt ata gga gga tca acc cca gaa caa att aaa ttg gaa     1344
 Lys Thr Glu Phe Ile Gly Gly Ser Thr Pro Glu Gln Ile Lys Leu Glu
         435                 440                 445

 ctt acc ttt aga gaa cta att gga tcg ttc cag gaa gag aaa gga gat     1392
 Leu Thr Phe Arg Glu Leu Ile Gly Ser Phe Gln Glu Glu Lys Gly Asp
     450                 455                 460

 cca tct att aag ttt ttc cat gtg tct agt gga gta gat gga gat aca     1440
 Pro Ser Ile Lys Phe Phe His Val Ser Ser Gly Val Asp Gly Asp Thr
 465                 470                 475                 480

 aca tcg tca gat gac ttt gac tgg cca cga att gta ctg aaa ata aat     1488
 Thr Ser Ser Asp Asp Phe Asp Trp Pro Arg Ile Val Leu Lys Ile Asn
                 485                 490                 495

 cca cca gcc atg cat tcc att ttg gag aga att gca gct gaa gaa gaa     1536
 Pro Pro Ala Met His Ser Ile Leu Glu Arg Ile Ala Ala Glu Glu Glu
             500                 505                 510

 gag gag aat gat ggt cac tac cag gag gaa gag gaa gga ggt gct cat     1584
 Glu Glu Asn Asp Gly His Tyr Gln Glu Glu Glu Glu Gly Gly Ala His
         515                 520                 525

 tcc ttg aaa gat atg gtg atg cca gga gac cct gta gaa atg aca gaa     1632
 Ser Leu Lys Asp Met Val Met Pro Gly Asp Pro Val Glu Met Thr Glu
     530                 535                 540

 ttt cag gat aaa gca atc agc aat tct cac tat gtg ctg gaa ctt acg     1680
 Phe Gln Asp Lys Ala Ile Ser Asn Ser His Tyr Val Leu Glu Leu Thr
 545                 550                 555                 560

 tta cca aat att tat gta aca cta cct aat aag agc ttt tat gag aag     1728
 Leu Pro Asn Ile Tyr Val Thr Leu Pro Asn Lys Ser Phe Tyr Glu Lys
                 565                 570                 575

 ctt tat aat agg atc ttt aat gac ttg cta ctg tgg gaa cca aca gct     1776
 Leu Tyr Asn Arg Ile Phe Asn Asp Leu Leu Leu Trp Glu Pro Thr Ala
             580                 585                 590

 cct tca cca gtg gag aca ttc gag aat att tcc tat ggc att ggg ctt     1824
 Pro Ser Pro Val Glu Thr Phe Glu Asn Ile Ser Tyr Gly Ile Gly Leu
         595                 600                 605

 tca gta gcc agt cag ctc att aat act ttc aac aaa gat agt ttt agt     1872
 Ser Val Ala Ser Gln Leu Ile Asn Thr Phe Asn Lys Asp Ser Phe Ser
     610                 615                 620

 gca ttt aaa tct gca gtt cac tat gat gag gaa agt gga tct gag gag     1920
 Ala Phe Lys Ser Ala Val His Tyr Asp Glu Glu Ser Gly Ser Glu Glu
 625                 630                 635                 640

 gag act ttg cag tat ttt tcc act gtt gat ccc aac tat cgt tct cgc     1968
 Glu Thr Leu Gln Tyr Phe Ser Thr Val Asp Pro Asn Tyr Arg Ser Arg
                 645                 650                 655

 agg aaa aaa aaa tta gac tct cag aac aag aac tct cag agt ttt ctc     2016
 Arg Lys Lys Lys Leu Asp Ser Gln Asn Lys Asn Ser Gln Ser Phe Leu
             660                 665                 670

 tca gtt ctt ctg aat att aat cat gga tta ata gca gtg ttc aca gat     2064
 Ser Val Leu Leu Asn Ile Asn His Gly Leu Ile Ala Val Phe Thr Asp
         675                 680                 685

 gtg aag gaa ttt ctc att gcc gta gga ctg aaa gga gcc act ctc cag     2112
 Val Lys Glu Phe Leu Ile Ala Val Gly Leu Lys Gly Ala Thr Leu Gln
     690                 695                 700

 cat aga atg ctt cct tct ggg ctt agc tgg cat gag cag act gag ccc     2160
 His Arg Met Leu Pro Ser Gly Leu Ser Trp His Glu Gln Thr Glu Pro
 705                 710                 715                 720

 cgc ttt gag tta cac tgt tcc agc gat gtt gtc cat atc aga acg tgc     2208
 Arg Phe Glu Leu His Cys Ser Ser Asp Val Val His Ile Arg Thr Cys
                 725                 730                 735

 tca gac tct tgt gct gcg tta atg aat ctc att cag tac att gca agc     2256
 Ser Asp Ser Cys Ala Ala Leu Met Asn Leu Ile Gln Tyr Ile Ala Ser
             740                 745                 750

 tat ggt gac ttg cag aca cct aac aag gca gat atg aag cct gga gcc     2304
 Tyr Gly Asp Leu Gln Thr Pro Asn Lys Ala Asp Met Lys Pro Gly Ala
         755                 760                 765

 ttt caa aga agg tct aag gta gat tcc agt ggt cga tca tcc tca cgt     2352
 Phe Gln Arg Arg Ser Lys Val Asp Ser Ser Gly Arg Ser Ser Ser Arg
     770                 775                 780

 ggt cca gta ctt cct gaa gca gat caa caa atg tta cga gat ctg atg     2400
 Gly Pro Val Leu Pro Glu Ala Asp Gln Gln Met Leu Arg Asp Leu Met
 785                 790                 795                 800

 agt gat gct atg gag gag atc gac atg caa caa ggc acc tcg tca gta     2448
 Ser Asp Ala Met Glu Glu Ile Asp Met Gln Gln Gly Thr Ser Ser Val
                 805                 810                 815

 aaa cca cag gct aat ggt gtt ttg gat gaa aaa tct caa att cag gag     2496
 Lys Pro Gln Ala Asn Gly Val Leu Asp Glu Lys Ser Gln Ile Gln Glu
             820                 825                 830

 cca tgt tgt tca gac ctc ttc ctg ttt cct gac gag agt ggg aat gta     2544
 Pro Cys Cys Ser Asp Leu Phe Leu Phe Pro Asp Glu Ser Gly Asn Val
         835                 840                 845

 tcc cag gag tcc ggc ccc acc tat gcc tca ttc tct cac cat ttc atc     2592
 Ser Gln Glu Ser Gly Pro Thr Tyr Ala Ser Phe Ser His His Phe Ile
     850                 855                 860

 agt gat gca atg aca ggt gtg ccc act gag aat gat gac ttt tgc att     2640
 Ser Asp Ala Met Thr Gly Val Pro Thr Glu Asn Asp Asp Phe Cys Ile
 865                 870                 875                 880

 ctt ttt gca cca aaa gca gcc atg cag gta ata aat taa                 2679
 Leu Phe Ala Pro Lys Ala Ala Met Gln Val Ile Asn 
                 885                 890





      <210> 769
      <211> 1953
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (229)..(1953)

      <400> 769
 ttaccttcca cgctgtatgt ccgtgagaaa tacaatgaag acggtctgaa taatgaactg     60

 aaggctctca aaataggctg ctgcaaaagc tggtatattg tccggttgct ctctcagaat    120

 ctcgcgtgtc agcccttcaa gaagattccc aaatccttgt ggaattcggt agtgggtgtt    180

 ggagaatgga atcgacatct tcttggcggc ggtcagatcc ttgcaagc atg gtc gcg     237
                                                      Met Val Ala
                                                        1

 ccg ggg ctt gta ctc ggg ctg gtg ctg cca tta atc ctg tgg gcc gac      285
 Pro Gly Leu Val Leu Gly Leu Val Leu Pro Leu Ile Leu Trp Ala Asp
       5                  10                  15

 aga agt gca gtg gtt atc agg gct aag aaa tac aac ccc ctc act agc      333
 Arg Ser Ala Val Val Ile Arg Ala Lys Lys Tyr Asn Pro Leu Thr Ser
  20                  25                  30                  35

 tct gac tat tta agg ctc agt ttt gat ttc tgg tac cgc tta cag ata      381
 Ser Asp Tyr Leu Arg Leu Ser Phe Asp Phe Trp Tyr Arg Leu Gln Ile
                  40                  45                  50

 ttg gtg gtg gga aaa tgt att ggt ttt cgc ttt gct tca tac atc aat      429
 Leu Val Val Gly Lys Cys Ile Gly Phe Arg Phe Ala Ser Tyr Ile Asn
              55                  60                  65

 aat gat atg gtg ctg cag aag gag cct gct ggg gca gtg ata tgg ggc      477
 Asn Asp Met Val Leu Gln Lys Glu Pro Ala Gly Ala Val Ile Trp Gly
          70                  75                  80

 ttc ggt aca cct gga gcc aca gtg acc gtg acc ctg cgc caa ggt cag      525
 Phe Gly Thr Pro Gly Ala Thr Val Thr Val Thr Leu Arg Gln Gly Gln
      85                  90                  95

 gaa acc atc atg aag aaa gtg acc agt gtg aaa gct cac tct gat acg      573
 Glu Thr Ile Met Lys Lys Val Thr Ser Val Lys Ala His Ser Asp Thr
 100                 105                 110                 115

 tgg atg gtg gta ctg gat cct atg aag cct gga gga cct ttc gaa gtg      621
 Trp Met Val Val Leu Asp Pro Met Lys Pro Gly Gly Pro Phe Glu Val
                 120                 125                 130

 atg gca caa cag act ttg gag aaa ata aac ttc acc ctg aga gtt cat      669
 Met Ala Gln Gln Thr Leu Glu Lys Ile Asn Phe Thr Leu Arg Val His
             135                 140                 145

 gac gtc ctg ttt gga gat gtc tgg ctc tgt agt ggg cag agt aac atg      717
 Asp Val Leu Phe Gly Asp Val Trp Leu Cys Ser Gly Gln Ser Asn Met
         150                 155                 160

 cag atg act gtg tta cag ata ttt aat gct aca agg gag ttg tct aac      765
 Gln Met Thr Val Leu Gln Ile Phe Asn Ala Thr Arg Glu Leu Ser Asn
     165                 170                 175

 act gcg gca tat cag tct gtc cgc atc ctc tct gtc tct ccc att caa      813
 Thr Ala Ala Tyr Gln Ser Val Arg Ile Leu Ser Val Ser Pro Ile Gln
 180                 185                 190                 195

 gca gag cag gag ctg gag gac ctt gtt gcg gtt gac ttg cag tgg tct      861
 Ala Glu Gln Glu Leu Glu Asp Leu Val Ala Val Asp Leu Gln Trp Ser
                 200                 205                 210

 aag ccc acc tca gag gtg gtc cct gtg ttc ccc ctg gac ttt ttc ttt      909
 Lys Pro Thr Ser Glu Val Val Pro Val Phe Pro Leu Asp Phe Phe Phe
             215                 220                 225

 ttc tcc tgt gca tgc ttt cct tgg tgc tca gat gct cct aca ttt ata      957
 Phe Ser Cys Ala Cys Phe Pro Trp Cys Ser Asp Ala Pro Thr Phe Ile
         230                 235                 240

 agt agt aat tca ctt aac aaa tat ttg agt gtc tac tat gtg ctc gac     1005
 Ser Ser Asn Ser Leu Asn Lys Tyr Leu Ser Val Tyr Tyr Val Leu Asp
     245                 250                 255

 act gtt cta agt gct ggg gat att gta gtc cct aac ctt aat cac atc     1053
 Thr Val Leu Ser Ala Gly Asp Ile Val Val Pro Asn Leu Asn His Ile
 260                 265                 270                 275

 tac aaa gtg cct ttc gcc atg caa ggt aac aca gcc aca ggt tcc agg     1101
 Tyr Lys Val Pro Phe Ala Met Gln Gly Asn Thr Ala Thr Gly Ser Arg
                 280                 285                 290

 gat gag tgt gtc gac gtc ttt ggg gtc tgt tat ttt gcc tac acc cca     1149
 Asp Glu Cys Val Asp Val Phe Gly Val Cys Tyr Phe Ala Tyr Thr Pro
             295                 300                 305

 cat tct cat tct caa gca ttt tca aaa aac tta ggc cat gga tat ttc     1197
 His Ser His Ser Gln Ala Phe Ser Lys Asn Leu Gly His Gly Tyr Phe
         310                 315                 320

 aag tac atg tca gca gtg tgc tgg ctc ttt gga cgt cac ctt tat gac     1245
 Lys Tyr Met Ser Ala Val Cys Trp Leu Phe Gly Arg His Leu Tyr Asp
     325                 330                 335

 act ctg cag tat ccc atc ggg ctg atc gcc tcc agc tgg ggc ggg aca     1293
 Thr Leu Gln Tyr Pro Ile Gly Leu Ile Ala Ser Ser Trp Gly Gly Thr
 340                 345                 350                 355

 ccc att gaa gcc tgg tca tct gga cgg tca ctg aaa gcc tgt ggg gtc     1341
 Pro Ile Glu Ala Trp Ser Ser Gly Arg Ser Leu Lys Ala Cys Gly Val
                 360                 365                 370

 cct aaa caa ggg tac gat gtg ggt aaa ggc ttc tct gtt cat gtc aac     1389
 Pro Lys Gln Gly Tyr Asp Val Gly Lys Gly Phe Ser Val His Val Asn
             375                 380                 385

 acc tgt tcc tgt gtt gag agg aag agg ttt atg ggc att ggt act ctt     1437
 Thr Cys Ser Cys Val Glu Arg Lys Arg Phe Met Gly Ile Gly Thr Leu
         390                 395                 400

 tcc tgt ggc gtt gtt act gtg atc ttc att atg acc ctg gct ggt gca     1485
 Ser Cys Gly Val Val Thr Val Ile Phe Ile Met Thr Leu Ala Gly Ala
     405                 410                 415

 cat ggt tcc act ttg tct tct ggg ata ttc tca ata tat caa agt gac     1533
 His Gly Ser Thr Leu Ser Ser Gly Ile Phe Ser Ile Tyr Gln Ser Asp
 420                 425                 430                 435

 tct ttg aag tgt aag tcg ggt cgg aag gct cca gtg ggt ccc cat ttg     1581
 Ser Leu Lys Cys Lys Ser Gly Arg Lys Ala Pro Val Gly Pro His Leu
                 440                 445                 450

 tct aag aag agc tca gac gat gga ttt ccc cag atc cgt tgg cat caa     1629
 Ser Lys Lys Ser Ser Asp Asp Gly Phe Pro Gln Ile Arg Trp His Gln
             455                 460                 465

 aca gca gac ttc ggc tat gtc ccc aac cca aag atg ccc aat act ttc     1677
 Thr Ala Asp Phe Gly Tyr Val Pro Asn Pro Lys Met Pro Asn Thr Phe
         470                 475                 480

 atg gct gta gct atg gat ctc tgt gat aga gac tcg cct ttt ggc agc     1725
 Met Ala Val Ala Met Asp Leu Cys Asp Arg Asp Ser Pro Phe Gly Ser
     485                 490                 495

 atc cac cct cga gat aaa cag act gtg gct tat cgg ctg cat ttg ggg     1773
 Ile His Pro Arg Asp Lys Gln Thr Val Ala Tyr Arg Leu His Leu Gly
 500                 505                 510                 515

 gcc cgt gct ctg gct tat ggt gag aag aat ttg acc ttt gaa gga cca     1821
 Ala Arg Ala Leu Ala Tyr Gly Glu Lys Asn Leu Thr Phe Glu Gly Pro
                 520                 525                 530

 ctg cct gag aag ata gaa ctc ttg gct cac aag ggg ctg ctc aat ctc     1869
 Leu Pro Glu Lys Ile Glu Leu Leu Ala His Lys Gly Leu Leu Asn Leu
             535                 540                 545

 aca tat tac cag caa atc cag gtg cag aaa aag gac aac aag ata ttt     1917
 Thr Tyr Tyr Gln Gln Ile Gln Val Gln Lys Lys Asp Asn Lys Ile Phe
         550                 555                 560

 gag aca gcc ctt ggt aac ctg ctg ctg ggt aac taa                     1953
 Glu Thr Ala Leu Gly Asn Leu Leu Leu Gly Asn 
     565                 570





      <210> 770
      <211> 654
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (1)..(654)

      <400> 770
  atg ccc ttc act cag ggc cta cag cag tgt ctg ctg ctg gca aca cct      48
  Met Pro Phe Thr Gln Gly Leu Gln Gln Cys Leu Leu Leu Ala Thr Pro
    1               5                  10                  15

 gct gct ggc agc acc ctc aga gct aca tct ctc cct ggt cac tct gct       96
 Ala Ala Gly Ser Thr Leu Arg Ala Thr Ser Leu Pro Gly His Ser Ala
              20                  25                  30

 aga ggc cat gat gga gct cag acc atc tcc aac gtt ggc ctg ctc tgg      144
 Arg Gly His Asp Gly Ala Gln Thr Ile Ser Asn Val Gly Leu Leu Trp
          35                  40                  45

 cat cag agc cag tca cgc cac acc agg ctc atg ctg gag ccc aat cca      192
 His Gln Ser Gln Ser Arg His Thr Arg Leu Met Leu Glu Pro Asn Pro
      50                  55                  60

 atg ctc aag cac ctc aca ggc tgg ctc ctt agc cac agt gtg ccc agg      240
 Met Leu Lys His Leu Thr Gly Trp Leu Leu Ser His Ser Val Pro Arg
  65                  70                  75                  80

 gag aag gtg gat aaa gag ctc acc aag gtc ctc ctg gag ctg tac ggc      288
 Glu Lys Val Asp Lys Glu Leu Thr Lys Val Leu Leu Glu Leu Tyr Gly
                  85                  90                  95

 aaa gag gcc aag tac aac cac agc tac ctg gtt ttt cca aag gat atg      336
 Lys Glu Ala Lys Tyr Asn His Ser Tyr Leu Val Phe Pro Lys Asp Met
             100                 105                 110

 gaa gag tct cca atg cta tat ctt ttc atc gaa gag atg gaa aga gta      384
 Glu Glu Ser Pro Met Leu Tyr Leu Phe Ile Glu Glu Met Glu Arg Val
         115                 120                 125

 cat ctg acc aag atc tgg tta cag caa tgc aga gat ctt gca gta cat      432
 His Leu Thr Lys Ile Trp Leu Gln Gln Cys Arg Asp Leu Ala Val His
     130                 135                 140

 act gca gca aaa tca gtg aag atg aag aag agt aat cta aag aac ttt      480
 Thr Ala Ala Lys Ser Val Lys Met Lys Lys Ser Asn Leu Lys Asn Phe
 145                 150                 155                 160

 atg gct gca gag gat gag ggg aat gaa gac aaa cat atc aaa aaa ctg      528
 Met Ala Ala Glu Asp Glu Gly Asn Glu Asp Lys His Ile Lys Lys Leu
                 165                 170                 175

 ctg gat acc aca gac aac aag tct tca gca cta act agc cct aat ttt      576
 Leu Asp Thr Thr Asp Asn Lys Ser Ser Ala Leu Thr Ser Pro Asn Phe
             180                 185                 190

 caa gtg gaa tca tct cca aaa ccc act ttc cca gaa gct gga cct gaa      624
 Gln Val Glu Ser Ser Pro Lys Pro Thr Phe Pro Glu Ala Gly Pro Glu
         195                 200                 205

 ata tcc ttt aat ttc att tgc caa gac tag                              654
 Ile Ser Phe Asn Phe Ile Cys Gln Asp 
     210                 215





      <210> 771
      <211> 1164
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (1)..(1164)

      <400> 771
  atg ctt ttt cat atc ttc ctg tcc atg ttt gcc ata tgt gtg aat gta      48
  Met Leu Phe His Ile Phe Leu Ser Met Phe Ala Ile Cys Val Asn Val
    1               5                  10                  15

 aag atg tcc tgg cag tca gta act ttt gaa agg cag cct gcc tcc ttc       96
 Lys Met Ser Trp Gln Ser Val Thr Phe Glu Arg Gln Pro Ala Ser Phe
              20                  25                  30

 atc cgt atc gtt ggg aca cac aac aca gca aat gag cta ctc agt gtt      144
 Ile Arg Ile Val Gly Thr His Asn Thr Ala Asn Glu Leu Leu Ser Val
          35                  40                  45

 tgt gaa ccc aga gac ttt gtg cta gct tca aaa act atc gat gga ttt      192
 Cys Glu Pro Arg Asp Phe Val Leu Ala Ser Lys Thr Ile Asp Gly Phe
      50                  55                  60

 ggt cta tgg cat gga aag gtc tgt ctg tgt gtg tac aat aaa ggg aaa      240
 Gly Leu Trp His Gly Lys Val Cys Leu Cys Val Tyr Asn Lys Gly Lys
  65                  70                  75                  80

 tct gct tta gga ggc aag agt gag gat gct gtc acc gca gcc ttg ttc      288
 Ser Ala Leu Gly Gly Lys Ser Glu Asp Ala Val Thr Ala Ala Leu Phe
                  85                  90                  95

 atc ctg aac cca acg gga tac cac gag cgt cca tcc aca gag gat gga      336
 Ile Leu Asn Pro Thr Gly Tyr His Glu Arg Pro Ser Thr Glu Asp Gly
             100                 105                 110

 cca tgg gcc aga gcg ttg gtg tgg gat tcc aaa ggg aat gag ctc tca      384
 Pro Trp Ala Arg Ala Leu Val Trp Asp Ser Lys Gly Asn Glu Leu Ser
         115                 120                 125

 gga atc act tgt gac agc ctg aag cca gat gaa gga ata act gaa gat      432
 Gly Ile Thr Cys Asp Ser Leu Lys Pro Asp Glu Gly Ile Thr Glu Asp
     130                 135                 140

 ggc atc aag gct gtg act gcc atg ccc ttg gag aat ggc aga gct ctg      480
 Gly Ile Lys Ala Val Thr Ala Met Pro Leu Glu Asn Gly Arg Ala Leu
 145                 150                 155                 160

 atg gtc agg gcc atg gct tac cct tgc ttg cgg ggc gct gag ctc ggt      528
 Met Val Arg Ala Met Ala Tyr Pro Cys Leu Arg Gly Ala Glu Leu Gly
                 165                 170                 175

 gct gtg ccc tgt ctg cac agt gct ggc acg gtg ttg gca cag agt tca      576
 Ala Val Pro Cys Leu His Ser Ala Gly Thr Val Leu Ala Gln Ser Ser
             180                 185                 190

 tgg tgc ttc cag gct gac ctg ctg tca gat aaa gag aag tat ggg gac      624
 Trp Cys Phe Gln Ala Asp Leu Leu Ser Asp Lys Glu Lys Tyr Gly Asp
         195                 200                 205

 gat ggg gtg gca cta aca gta gat gtc att gag ttt cca gaa gag agg      672
 Asp Gly Val Ala Leu Thr Val Asp Val Ile Glu Phe Pro Glu Glu Arg
     210                 215                 220

 gaa ggg caa ggt tta aat ggc atg cag gac aac tgg aat gcc ccc atc      720
 Glu Gly Gln Gly Leu Asn Gly Met Gln Asp Asn Trp Asn Ala Pro Ile
 225                 230                 235                 240

 tct ctc gct gac acg gat cca gtc ata cct ggg gct gga cgg gat ttg      768
 Ser Leu Ala Asp Thr Asp Pro Val Ile Pro Gly Ala Gly Arg Asp Leu
                 245                 250                 255

 gag gcc ctg gtc att tgc aga gtg aat gga gtg tgg tgc gct tct gat      816
 Glu Ala Leu Val Ile Cys Arg Val Asn Gly Val Trp Cys Ala Ser Asp
             260                 265                 270

 tgt gcg gca ctg tcg agc gtg ttc cta aga gcg aat gtc tgt atc gag      864
 Cys Ala Ala Leu Ser Ser Val Phe Leu Arg Ala Asn Val Cys Ile Glu
         275                 280                 285

 cag gtg act cga aac tgt gta tct cat ttg tac acc gac atc cac agc      912
 Gln Val Thr Arg Asn Cys Val Ser His Leu Tyr Thr Asp Ile His Ser
     290                 295                 300

 agc ctc att cac agt aac tac aac atg gaa gca acc cca gtg ccc act      960
 Ser Leu Ile His Ser Asn Tyr Asn Met Glu Ala Thr Pro Val Pro Thr
 305                 310                 315                 320

 gac aaa ggg gtg ggc aag cac gtg tgt ttc atc ata cgg tgc agt agc     1008
 Asp Lys Gly Val Gly Lys His Val Cys Phe Ile Ile Arg Cys Ser Ser
                 325                 330                 335

 atc cac ctt aag aag gac aca gac ata tct acc atg tgg atg agc ccg     1056
 Ile His Leu Lys Lys Asp Thr Asp Ile Ser Thr Met Trp Met Ser Pro
             340                 345                 350

 gag gac atc gtg ctg ggt gaa atc ggc cag aca caa aca gac gag tac     1104
 Glu Asp Ile Val Leu Gly Glu Ile Gly Gln Thr Gln Thr Asp Glu Tyr
         355                 360                 365

 tgt atg att cca ctt cca gtt ctg gag atg gac ggt ggc aat ggt tgc     1152
 Cys Met Ile Pro Leu Pro Val Leu Glu Met Asp Gly Gly Asn Gly Cys
     370                 375                 380

 acc aca tta tga                                                     1164
 Thr Thr Leu 
 385





      <210> 772
      <211> 579
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (1)..(579)

      <400> 772
  atg gcc agc ctg ttc cgg tcc tat ctg cca gca atc tgg ctg ctg ctg      48
  Met Ala Ser Leu Phe Arg Ser Tyr Leu Pro Ala Ile Trp Leu Leu Leu
    1               5                  10                  15

 agc caa ctc ctt aga gaa agc cta gca gca gag ctg agg gga tgt ggt       96
 Ser Gln Leu Leu Arg Glu Ser Leu Ala Ala Glu Leu Arg Gly Cys Gly
              20                  25                  30

 ccc cga ttt gga aaa cac ttg ctg tca tat tgc ccc atg cct gag aag      144
 Pro Arg Phe Gly Lys His Leu Leu Ser Tyr Cys Pro Met Pro Glu Lys
          35                  40                  45

 aca ttc acc acc acc cca gga ggg tgg ctg ctg gaa tct gga cgt ccc      192
 Thr Phe Thr Thr Thr Pro Gly Gly Trp Leu Leu Glu Ser Gly Arg Pro
      50                  55                  60

 aaa gtc aac tca gac tct act gtg gct agt gcc tac aag ttt gtg gtt      240
 Lys Val Asn Ser Asp Ser Thr Val Ala Ser Ala Tyr Lys Phe Val Val
  65                  70                  75                  80

 ttt cat tgt aat gtg ctt tta tta aaa ggg tct cac cag aaa tct cat      288
 Phe His Cys Asn Val Leu Leu Leu Lys Gly Ser His Gln Lys Ser His
                  85                  90                  95

 ggg aag ttg ggg gta gag gag aag ctg cag gaa aaa cag aag aac agc      336
 Gly Lys Leu Gly Val Glu Glu Lys Leu Gln Glu Lys Gln Lys Asn Ser
             100                 105                 110

 ctc acc ttg gag gct ctt ggt gcc ttt ccc acc tgg cag cca gag ata      384
 Leu Thr Leu Glu Ala Leu Gly Ala Phe Pro Thr Trp Gln Pro Glu Ile
         115                 120                 125

 cag ggt gga gaa aac agg gaa tcc tca gag aag gtg act att ctc aaa      432
 Gln Gly Gly Glu Asn Arg Glu Ser Ser Glu Lys Val Thr Ile Leu Lys
     130                 135                 140

 cac cag cag gag tgt gtt gag aga gat gag atg aag aga aag aaa gtg      480
 His Gln Gln Glu Cys Val Glu Arg Asp Glu Met Lys Arg Lys Lys Val
 145                 150                 155                 160

 gcc tgg atg act aga ggg gaa att gaa ggg gac cag aga caa ggg aat      528
 Ala Trp Met Thr Arg Gly Glu Ile Glu Gly Asp Gln Arg Gln Gly Asn
                 165                 170                 175

 ttc act gtt cag acc atc ata gct gat ttg att agt gtt ttc aac att      576
 Phe Thr Val Gln Thr Ile Ile Ala Asp Leu Ile Ser Val Phe Asn Ile
             180                 185                 190

 tga                                                                  579
 






      <210> 773
      <211> 927
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (1)..(927)

      <400> 773
  atg gcc tgc acc gtg gtg ctc atc acc ggc tgt tcc tca ggt att ggc      48
  Met Ala Cys Thr Val Val Leu Ile Thr Gly Cys Ser Ser Gly Ile Gly
    1               5                  10                  15

 ctg cac ttg gca ata cat ctg gct ttg gac cca tcc cag agc ttc aaa       96
 Leu His Leu Ala Ile His Leu Ala Leu Asp Pro Ser Gln Ser Phe Lys
              20                  25                  30

 gtg tat gcc acg ttg agg gac ctg aaa aca cag ggc cgg ctg tgg gag      144
 Val Tyr Ala Thr Leu Arg Asp Leu Lys Thr Gln Gly Arg Leu Trp Glu
          35                  40                  45

 gcg gcc cgg gcc ctg gca tgc cct cag gga tcc ctg gag agg ttg cag      192
 Ala Ala Arg Ala Leu Ala Cys Pro Gln Gly Ser Leu Glu Arg Leu Gln
      50                  55                  60

 ctg gat gta agg aac tca agc tcc ctg gcc gct gcc cgg gaa cgc gtg      240
 Leu Asp Val Arg Asn Ser Ser Ser Leu Ala Ala Ala Arg Glu Arg Val
  65                  70                  75                  80

 acc gag ggc cgt gtg gat gtg ctg gtg tgt gac aca ggc ctg ggc ctg      288
 Thr Glu Gly Arg Val Asp Val Leu Val Cys Asp Thr Gly Leu Gly Leu
                  85                  90                  95

 ctg ggg ccg ctg ggg gag gac gct gtg gcc tct gta ctg gat gtg aat      336
 Leu Gly Pro Leu Gly Glu Asp Ala Val Ala Ser Val Leu Asp Val Asn
             100                 105                 110

 gta gta ggt act gtg cgg gtg ctg cag gac ttc ctg cca gac atg aag      384
 Val Val Gly Thr Val Arg Val Leu Gln Asp Phe Leu Pro Asp Met Lys
         115                 120                 125

 cgg ccg ggt tcg gga cgc gtg ttg gtg act ggg agc atg gga gga ttg      432
 Arg Pro Gly Ser Gly Arg Val Leu Val Thr Gly Ser Met Gly Gly Leu
     130                 135                 140

 atg ggg ctg cct ttc aat gac gtt tat tgc gcc agc aag ttc gcg ctc      480
 Met Gly Leu Pro Phe Asn Asp Val Tyr Cys Ala Ser Lys Phe Ala Leu
 145                 150                 155                 160

 gaa ggc tta tgc gag agt ctg gcg gtt ctg ctg ctg ccc ttt ggg gtc      528
 Glu Gly Leu Cys Glu Ser Leu Ala Val Leu Leu Leu Pro Phe Gly Val
                 165                 170                 175

 cac aag gag atc tac cgc gag gag gcg cag cac cct gag gag gtg gtg      576
 His Lys Glu Ile Tyr Arg Glu Glu Ala Gln His Pro Glu Glu Val Val
             180                 185                 190

 aag gtc ttc ctc acc gct atg cgc gcc ccg aag ccg acc ctg cgc tac      624
 Lys Val Phe Leu Thr Ala Met Arg Ala Pro Lys Pro Thr Leu Arg Tyr
         195                 200                 205

 ttc aca acc agg cgc ttc ctg cac cag ctg ctg atg cgc ctg gac gac      672
 Phe Thr Thr Arg Arg Phe Leu His Gln Leu Leu Met Arg Leu Asp Asp
     210                 215                 220

 ccc ttt ggc ttc gac tac gcc gcc gcc atg cac cgg gac gtg ttc gcc      720
 Pro Phe Gly Phe Asp Tyr Ala Ala Ala Met His Arg Asp Val Phe Ala
 225                 230                 235                 240

 gac gat ccc gca gag gcc gag gct ggg gcc ggg gct ggg gcc gag gcc      768
 Asp Asp Pro Ala Glu Ala Glu Ala Gly Ala Gly Ala Gly Ala Glu Ala
                 245                 250                 255

 ggg ggc ggg gcc ggt ggg atg gga gac cct gag ctc agc gat cct ctg      816
 Gly Gly Gly Ala Gly Gly Met Gly Asp Pro Glu Leu Ser Asp Pro Leu
             260                 265                 270

 gcc gcc ccg caa gaa agg ctc cgt cag cca ctg tct ccc gcg ccc tcc      864
 Ala Ala Pro Gln Glu Arg Leu Arg Gln Pro Leu Ser Pro Ala Pro Ser
         275                 280                 285

 ttt gtc tcc tgg gcc tgt gcg gtc cct ggg gat ggg acg gcg gtg acg      912
 Phe Val Ser Trp Ala Cys Ala Val Pro Gly Asp Gly Thr Ala Val Thr
     290                 295                 300

 gct gtg gat ggc taa                                                  927
 Ala Val Asp Gly 
 305





      <210> 774
      <211> 1020
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (1)..(1020)

      <400> 774
  atg ggg gtc ccc aga gtc att ctg ctc tgc ctc ttt ggg gct gcg ctc      48
  Met Gly Val Pro Arg Val Ile Leu Leu Cys Leu Phe Gly Ala Ala Leu
    1               5                  10                  15

 tgc ctg aca ggg tcc caa gcc ctg cag tgc tac agc ttt gag cac acc       96
 Cys Leu Thr Gly Ser Gln Ala Leu Gln Cys Tyr Ser Phe Glu His Thr
              20                  25                  30

 tac ttt ggc ccc ttt gac ctc agg gcc atg aag ctg ccc agc atc tcc      144
 Tyr Phe Gly Pro Phe Asp Leu Arg Ala Met Lys Leu Pro Ser Ile Ser
          35                  40                  45

 tgt cct cat gag tgc ttt gag gct atc ctg tct ctg gac acc ggg tat      192
 Cys Pro His Glu Cys Phe Glu Ala Ile Leu Ser Leu Asp Thr Gly Tyr
      50                  55                  60

 cgc gcg ccg gtg acc ctg gtg cgg aag ggc tgc tgg acc ggg cct cct      240
 Arg Ala Pro Val Thr Leu Val Arg Lys Gly Cys Trp Thr Gly Pro Pro
  65                  70                  75                  80

 gcg ggc cag acg caa tcg aac ccg gac gcg ctg ccg cca gac tac tcg      288
 Ala Gly Gln Thr Gln Ser Asn Pro Asp Ala Leu Pro Pro Asp Tyr Ser
                  85                  90                  95

 gtg gtg cgc ggc tgc aca act gac aaa tgc aac gcc cac ctc atg act      336
 Val Val Arg Gly Cys Thr Thr Asp Lys Cys Asn Ala His Leu Met Thr
             100                 105                 110

 cat gac gcc ctc ccc aac ctg agc caa gca ccc gac ccg ccg acg ctc      384
 His Asp Ala Leu Pro Asn Leu Ser Gln Ala Pro Asp Pro Pro Thr Leu
         115                 120                 125

 agc ggc gcc gag tgc tac gcc tgt atc ggg gtc cac cag gat gac tgc      432
 Ser Gly Ala Glu Cys Tyr Ala Cys Ile Gly Val His Gln Asp Asp Cys
     130                 135                 140

 gct atc ggc agg tcc cga cga gtc cag tgt cac cag gac cag acc gcc      480
 Ala Ile Gly Arg Ser Arg Arg Val Gln Cys His Gln Asp Gln Thr Ala
 145                 150                 155                 160

 tgc ttc cag ggc aat ggc aga atg aca gtt ggc aat ttc tca gtc cct      528
 Cys Phe Gln Gly Asn Gly Arg Met Thr Val Gly Asn Phe Ser Val Pro
                 165                 170                 175

 gtg tac atc aga acc tgc cac cgg ccc tcc tgc acc acc gag ggc acc      576
 Val Tyr Ile Arg Thr Cys His Arg Pro Ser Cys Thr Thr Glu Gly Thr
             180                 185                 190

 acc agc ccc tgg aca gcc atc gac ctc cag ggc tcc tgc tgt gag ggg      624
 Thr Ser Pro Trp Thr Ala Ile Asp Leu Gln Gly Ser Cys Cys Glu Gly
         195                 200                 205

 tac ctc tgc aac agg aaa tcc atg acc cag ccc ttc acc agt gct tca      672
 Tyr Leu Cys Asn Arg Lys Ser Met Thr Gln Pro Phe Thr Ser Ala Ser
     210                 215                 220

 gcc acc acc cct ccc cga gca cta cag gtc ctg gcc ctg ctc ctc cca      720
 Ala Thr Thr Pro Pro Arg Ala Leu Gln Val Leu Ala Leu Leu Leu Pro
 225                 230                 235                 240

 gtc ctc ctg ctg aaa aac aca caa ggc aaa gtt cag cga ggt gaa att      768
 Val Leu Leu Leu Lys Asn Thr Gln Gly Lys Val Gln Arg Gly Glu Ile
                 245                 250                 255

 ctc caa gct ata aag atc agg gaa gac ttc ctg gag gaa ttc acc ctt      816
 Leu Gln Ala Ile Lys Ile Arg Glu Asp Phe Leu Glu Glu Phe Thr Leu
             260                 265                 270

 gag caa aat cct aaa gga tca ata gta gct ggc aaa aag aag cag gag      864
 Glu Gln Asn Pro Lys Gly Ser Ile Val Ala Gly Lys Lys Lys Gln Glu
         275                 280                 285

 gaa gcg cat tct agg cca tgt gac aag ggc ttc agg tgt ctt tac atc      912
 Glu Ala His Ser Arg Pro Cys Asp Lys Gly Phe Arg Cys Leu Tyr Ile
     290                 295                 300

 ctg aca tac aag ggg aag ctg gat gtc ttc att cat cct tca cat tta      960
 Leu Thr Tyr Lys Gly Lys Leu Asp Val Phe Ile His Pro Ser His Leu
 305                 310                 315                 320

 ctg agc acc tac tat gtg caa ggc act gtt cca gtt gct ggg cat gca     1008
 Leu Ser Thr Tyr Tyr Val Gln Gly Thr Val Pro Val Ala Gly His Ala
                 325                 330                 335

 gca ggg aac taa                                                     1020
 Ala Gly Asn 






      <210> 775
      <211> 2790
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (1)..(2790)

      <400> 775
  atg ggg atc atc ttg ctg gct cta ctc ctc ctg gta ttt gct ggg gct      48
  Met Gly Ile Ile Leu Leu Ala Leu Leu Leu Leu Val Phe Ala Gly Ala
    1               5                  10                  15

 aga aaa tcc aag atg gct tct tca ctc aca ttt ctg gtg cct cag gtg       96
 Arg Lys Ser Lys Met Ala Ser Ser Leu Thr Phe Leu Val Pro Gln Val
              20                  25                  30

 atc att tac aat tac tca ctg act cag tcc cgg gaa gag gcg gtg caa      144
 Ile Ile Tyr Asn Tyr Ser Leu Thr Gln Ser Arg Glu Glu Ala Val Gln
          35                  40                  45

 aat ggg acg ctc tat cca ggc ccc ctc ctg gct ggc gag cgg gcg cca      192
 Asn Gly Thr Leu Tyr Pro Gly Pro Leu Leu Ala Gly Glu Arg Ala Pro
      50                  55                  60

 cat ctg gcc cgc aca tct gcg ctg ccg gcc cgg cgc ggg gtc cgg aga      240
 His Leu Ala Arg Thr Ser Ala Leu Pro Ala Arg Arg Gly Val Arg Arg
  65                  70                  75                  80

 ggg cgc ggc gcg gag gcg cag cca ggg gtc cgg gaa ggc gcc gtc cgc      288
 Gly Arg Gly Ala Glu Ala Gln Pro Gly Val Arg Glu Gly Ala Val Arg
                  85                  90                  95

 tgc gct ggg ggc tcg gtc tat gac gag cag cgg ggt ctg cca tgg gtc      336
 Cys Ala Gly Gly Ser Val Tyr Asp Glu Gln Arg Gly Leu Pro Trp Val
             100                 105                 110

 ggg ggc tgc tca ggg gcc tgt ggc cgc tgc aca tcg tcc tgt gga cgc      384
 Gly Gly Cys Ser Gly Ala Cys Gly Arg Cys Thr Ser Ser Cys Gly Arg
         115                 120                 125

 gta tcg cca gca cga tcc cac cgc acg ttc aga agt cgg gcc caa agt      432
 Val Ser Pro Ala Arg Ser His Arg Thr Phe Arg Ser Arg Ala Gln Ser
     130                 135                 140

 ggc aag gag agg gaa gaa gta aat ctt gga aat gac ctc ctg aag aga      480
 Gly Lys Glu Arg Glu Glu Val Asn Leu Gly Asn Asp Leu Leu Lys Arg
 145                 150                 155                 160

 acc tgt gac ctc caa gtg agg gac ttg gcc agc tgg aaa aga ttc cac      528
 Thr Cys Asp Leu Gln Val Arg Asp Leu Ala Ser Trp Lys Arg Phe His
                 165                 170                 175

 aga ggg agc cag aac aca gat acc tta aat gtg ctc ctc att gct tcc      576
 Arg Gly Ser Gln Asn Thr Asp Thr Leu Asn Val Leu Leu Ile Ala Ser
             180                 185                 190

 ctt aga tac cgc tgg gtc acc cca ttg gcc aaa ctt act gga agc ttg      624
 Leu Arg Tyr Arg Trp Val Thr Pro Leu Ala Lys Leu Thr Gly Ser Leu
         195                 200                 205

 agg gca aga gag ccg gtt gat gta gtc cat aaa gat gag cct cct ggg      672
 Arg Ala Arg Glu Pro Val Asp Val Val His Lys Asp Glu Pro Pro Gly
     210                 215                 220

 gca gac agt ctg gtg acc aag gtt aat aac gac atg ata gtc act gac      720
 Ala Asp Ser Leu Val Thr Lys Val Asn Asn Asp Met Ile Val Thr Asp
 225                 230                 235                 240

 aac aac ggt gca gtc aag ttt cca caa ctg tgt aaa ttt tgt gat gtg      768
 Asn Asn Gly Ala Val Lys Phe Pro Gln Leu Cys Lys Phe Cys Asp Val
                 245                 250                 255

 aga ttt tcc acc tgt gac aac cag aaa tcc tgc atg agc aac tgc agc      816
 Arg Phe Ser Thr Cys Asp Asn Gln Lys Ser Cys Met Ser Asn Cys Ser
             260                 265                 270

 atc acc tcc atc tgt gag aag cca cag gaa gtc tgt gtg gct gta tgg      864
 Ile Thr Ser Ile Cys Glu Lys Pro Gln Glu Val Cys Val Ala Val Trp
         275                 280                 285

 aga aag aat gac gag aac ata aca cta gag aca gtt tgc cat gac ccc      912
 Arg Lys Asn Asp Glu Asn Ile Thr Leu Glu Thr Val Cys His Asp Pro
     290                 295                 300

 aag ctc ccc tac cat gac ttt att ctg gaa gat gct gct tct cca aag      960
 Lys Leu Pro Tyr His Asp Phe Ile Leu Glu Asp Ala Ala Ser Pro Lys
 305                 310                 315                 320

 tgc att atg aag gaa aaa aaa aag cct ggt gag act ttc ttc atg tgt     1008
 Cys Ile Met Lys Glu Lys Lys Lys Pro Gly Glu Thr Phe Phe Met Cys
                 325                 330                 335

 tcc tgt agc tct gat gag tgc aat gac aac atc atc ttc tca gaa gac     1056
 Ser Cys Ser Ser Asp Glu Cys Asn Asp Asn Ile Ile Phe Ser Glu Asp
             340                 345                 350

 tca tta cat ttt tat gat gaa gtg aaa ccc gtg aat tgg ctc ctc cag     1104
 Ser Leu His Phe Tyr Asp Glu Val Lys Pro Val Asn Trp Leu Leu Gln
         355                 360                 365

 act tct cat ttt aat gac aaa aaa gtg ggt ctc cag aga gga gct ggg     1152
 Thr Ser His Phe Asn Asp Lys Lys Val Gly Leu Gln Arg Gly Ala Gly
     370                 375                 380

 att ttc caa gat ctc ata gtt tgt tcc tca ctt ttt gtc cgt agg aga     1200
 Ile Phe Gln Asp Leu Ile Val Cys Ser Ser Leu Phe Val Arg Arg Arg
 385                 390                 395                 400

 atc ata gaa gaa cca gat aat ctt gtc tct tat aga agg aat acc ctt     1248
 Ile Ile Glu Glu Pro Asp Asn Leu Val Ser Tyr Arg Arg Asn Thr Leu
                 405                 410                 415

 acc ctt cca cat tcc cgt ggt ggt ggt aga tgt aaa atc aga cat ata     1296
 Thr Leu Pro His Ser Arg Gly Gly Gly Arg Cys Lys Ile Arg His Ile
             420                 425                 430

 ggt tca aac aat cga ttg caa agg agc act tgt caa aac act ggc tgg     1344
 Gly Ser Asn Asn Arg Leu Gln Arg Ser Thr Cys Gln Asn Thr Gly Trp
         435                 440                 445

 gaa tct gct cat gtg atg aag acc cca ggg ttt aga gaa tat aac acc     1392
 Glu Ser Ala His Val Met Lys Thr Pro Gly Phe Arg Glu Tyr Asn Thr
     450                 455                 460

 agc aat cct gac ttg ttg cta gtc ata ttt caa gtg aca ggc atc agc     1440
 Ser Asn Pro Asp Leu Leu Leu Val Ile Phe Gln Val Thr Gly Ile Ser
 465                 470                 475                 480

 ctc ctg cca cca ctg gga gtt gcc ata tct gtc atc atc atc ttc tac     1488
 Leu Leu Pro Pro Leu Gly Val Ala Ile Ser Val Ile Ile Ile Phe Tyr
                 485                 490                 495

 tgc tac cgc gtt aac cgg cag cag aag ctg agt tca acc tgg gaa acc     1536
 Cys Tyr Arg Val Asn Arg Gln Gln Lys Leu Ser Ser Thr Trp Glu Thr
             500                 505                 510

 ggc aag acg cgg aag ctc atg gag ttc agc gag cac tgt gcc atc atc     1584
 Gly Lys Thr Arg Lys Leu Met Glu Phe Ser Glu His Cys Ala Ile Ile
         515                 520                 525

 ctg gaa gat gac cgc tct gac atc agc tcc acg tgt gcc aac aac atc     1632
 Leu Glu Asp Asp Arg Ser Asp Ile Ser Ser Thr Cys Ala Asn Asn Ile
     530                 535                 540

 aac cac aac aca gag ctg ctg ccc att gag ctg gac acc ctg gtg ggg     1680
 Asn His Asn Thr Glu Leu Leu Pro Ile Glu Leu Asp Thr Leu Val Gly
 545                 550                 555                 560

 aaa ggt cgc ttt gct gag gtc tat aag gcc aag ctg aag cag aac act     1728
 Lys Gly Arg Phe Ala Glu Val Tyr Lys Ala Lys Leu Lys Gln Asn Thr
                 565                 570                 575

 tca gag cag ttt gag aca gtg gca gtc aag atc ttt ccc tat gag gag     1776
 Ser Glu Gln Phe Glu Thr Val Ala Val Lys Ile Phe Pro Tyr Glu Glu
             580                 585                 590

 tat gcc tct tgg aag aca gag aag gac atc ttc tca gac atc aat ctg     1824
 Tyr Ala Ser Trp Lys Thr Glu Lys Asp Ile Phe Ser Asp Ile Asn Leu
         595                 600                 605

 aag cat gag aac ata ctc cag ttc ctg acg gct gag gag cgg aag acg     1872
 Lys His Glu Asn Ile Leu Gln Phe Leu Thr Ala Glu Glu Arg Lys Thr
     610                 615                 620

 gag ttg ggg aaa caa tac tgg ctg atc acc gcc ttc cac gcc aag ggc     1920
 Glu Leu Gly Lys Gln Tyr Trp Leu Ile Thr Ala Phe His Ala Lys Gly
 625                 630                 635                 640

 aac cta cag gag tac ctg acg cgg cat gtc atc agc tgg gag gac ctg     1968
 Asn Leu Gln Glu Tyr Leu Thr Arg His Val Ile Ser Trp Glu Asp Leu
                 645                 650                 655

 cgc aag ctg ggc agc tcc ctc gcc cgg ggg att gct cac ctc cac agt     2016
 Arg Lys Leu Gly Ser Ser Leu Ala Arg Gly Ile Ala His Leu His Ser
             660                 665                 670

 gat cac act cca tgt ggg agg ccc aag atg ccc atc gtg cac agg gac     2064
 Asp His Thr Pro Cys Gly Arg Pro Lys Met Pro Ile Val His Arg Asp
         675                 680                 685

 ctc aag agc tcc aat atc ctc gtg aag aac gac cta acc tgc tgc ctg     2112
 Leu Lys Ser Ser Asn Ile Leu Val Lys Asn Asp Leu Thr Cys Cys Leu
     690                 695                 700

 tgt gac ttt ggg ctt tcc ctg cgt ctg gac cct act ctg tct gtg gat     2160
 Cys Asp Phe Gly Leu Ser Leu Arg Leu Asp Pro Thr Leu Ser Val Asp
 705                 710                 715                 720

 gac ctg gct aac agt ggg cag gtg gga act gca aga tac atg gct cca     2208
 Asp Leu Ala Asn Ser Gly Gln Val Gly Thr Ala Arg Tyr Met Ala Pro
                 725                 730                 735

 gaa gtc cta gaa tcc agg atg aat ttg gag aat gtt gag tcc ttc aag     2256
 Glu Val Leu Glu Ser Arg Met Asn Leu Glu Asn Val Glu Ser Phe Lys
             740                 745                 750

 cag acc gat gtc tac tcc atg gct ctg gtg ctc tgg gaa atg aca tct     2304
 Gln Thr Asp Val Tyr Ser Met Ala Leu Val Leu Trp Glu Met Thr Ser
         755                 760                 765

 cgc tgt aat gca gtg gga gga tca ttt ttc cct gaa cac act gtc ata     2352
 Arg Cys Asn Ala Val Gly Gly Ser Phe Phe Pro Glu His Thr Val Ile
     770                 775                 780

 gcc tcc cag gtg ccc tct gct atg tct tct ctg cag ttg tat gct gag     2400
 Ala Ser Gln Val Pro Ser Ala Met Ser Ser Leu Gln Leu Tyr Ala Glu
 785                 790                 795                 800

 tcc ttt tca ctg tta gag gct gtt act act att gac cat gag act gta     2448
 Ser Phe Ser Leu Leu Glu Ala Val Thr Thr Ile Asp His Glu Thr Val
                 805                 810                 815

 gat aga atg ggc aac aaa cat ctg ggg tgc cag gaa gta aaa gat tat     2496
 Asp Arg Met Gly Asn Lys His Leu Gly Cys Gln Glu Val Lys Asp Tyr
             820                 825                 830

 gag cct cca ttt ggt tcc aag gtg cgg gag cac ccc tgt gtc gaa agc     2544
 Glu Pro Pro Phe Gly Ser Lys Val Arg Glu His Pro Cys Val Glu Ser
         835                 840                 845

 atg aag gac aac gtg ttg aga gat cga ggg cga cca gaa att ccc agc     2592
 Met Lys Asp Asn Val Leu Arg Asp Arg Gly Arg Pro Glu Ile Pro Ser
     850                 855                 860

 ttc tgg ctc aac cac cag ggc atc cag atg gtg tgt gag acg ttg act     2640
 Phe Trp Leu Asn His Gln Gly Ile Gln Met Val Cys Glu Thr Leu Thr
 865                 870                 875                 880

 gag tgc tgg gac cac gac cca gag gcc cgt ctc aca gcc cag tgt gtg     2688
 Glu Cys Trp Asp His Asp Pro Glu Ala Arg Leu Thr Ala Gln Cys Val
                 885                 890                 895

 gca gaa cgc ttc agt gag ctg gag cat ctg gac agg ctc tcg ggg agg     2736
 Ala Glu Arg Phe Ser Glu Leu Glu His Leu Asp Arg Leu Ser Gly Arg
             900                 905                 910

 agc tgc tcg gag gag aag att cct gaa gac ggc tcc cta aac act acc     2784
 Ser Cys Ser Glu Glu Lys Ile Pro Glu Asp Gly Ser Leu Asn Thr Thr
         915                 920                 925

 aaa tag                                                             2790
 Lys 






      <210> 776
      <211> 453
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (1)..(453)

      <400> 776
  atg agg act gga cta gag ctt tgg cag tcg ctg cta acc ccc ctg gtg      48
  Met Arg Thr Gly Leu Glu Leu Trp Gln Ser Leu Leu Thr Pro Leu Val
    1               5                  10                  15

 cct ggc tgg tgt ctt tta cat gtg acc ctc aac ccc aat tct aga agg       96
 Pro Gly Trp Cys Leu Leu His Val Thr Leu Asn Pro Asn Ser Arg Arg
              20                  25                  30

 ctg cac gtt ctc gcc cac tca cgt gca aaa gcc agc aag gat ggg aag      144
 Leu His Val Leu Ala His Ser Arg Ala Lys Ala Ser Lys Asp Gly Lys
          35                  40                  45

 ggc ggc cag gcg gcc agg ctg cag gag gag tgt gac tat gtg cag atg      192
 Gly Gly Gln Ala Ala Arg Leu Gln Glu Glu Cys Asp Tyr Val Gln Met
      50                  55                  60

 atc gag gtg cag cac aag cag tgc ctg gag gag gcc cag ctg gag aat      240
 Ile Glu Val Gln His Lys Gln Cys Leu Glu Glu Ala Gln Leu Glu Asn
  65                  70                  75                  80

 gag aca ata ggc tgc agc aag atg tgg gac aac ctc acc tgc tgg cca      288
 Glu Thr Ile Gly Cys Ser Lys Met Trp Asp Asn Leu Thr Cys Trp Pro
                  85                  90                  95

 gcc acc cct cgg ggc cag gta gtt gtc ttg gcc tgt ccc ctc atc ttc      336
 Ala Thr Pro Arg Gly Gln Val Val Val Leu Ala Cys Pro Leu Ile Phe
             100                 105                 110

 aag ctc ttc tcc tcc att caa gtg aat gaa gca ctt acc agt gtg cca      384
 Lys Leu Phe Ser Ser Ile Gln Val Asn Glu Ala Leu Thr Ser Val Pro
         115                 120                 125

 ggc act gag ctg gac aaa cac agt gga gag agg ata aaa cag ccc ccg      432
 Gly Thr Glu Leu Asp Lys His Ser Gly Glu Arg Ile Lys Gln Pro Pro
     130                 135                 140

 ggg ctg ctc tcc cag agc tag                                          453
 Gly Leu Leu Ser Gln Ser 
 145                 150





      <210> 777
      <211> 702
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (1)..(702)

      <400> 777
  atg agg ctt ttc tcc atg cac ttc cat ctt gtg gca ctg gtg tcc ctt      48
  Met Arg Leu Phe Ser Met His Phe His Leu Val Ala Leu Val Ser Leu
    1               5                  10                  15

 agg act tgg gag tcc ctt gca gag agc tgt cac atc gat ttc tta aca       96
 Arg Thr Trp Glu Ser Leu Ala Glu Ser Cys His Ile Asp Phe Leu Thr
              20                  25                  30

 gcc gtg gcc cag aga aaa gtg ggg tgt gtc ccc tct ggg cca agg cca      144
 Ala Val Ala Gln Arg Lys Val Gly Cys Val Pro Ser Gly Pro Arg Pro
          35                  40                  45

 tta aga aat cac tgt gat gac ttc gat gtc ttt tct ccc aac tct atg      192
 Leu Arg Asn His Cys Asp Asp Phe Asp Val Phe Ser Pro Asn Ser Met
      50                  55                  60

 caa ggg act gta agt cgt aag gga cac ctg gct ggt ttc ttg cta ttt      240
 Gln Gly Thr Val Ser Arg Lys Gly His Leu Ala Gly Phe Leu Leu Phe
  65                  70                  75                  80

 aaa gat ttt tgt ttg aat gaa att aat gaa gct gta cct cag gtg aag      288
 Lys Asp Phe Cys Leu Asn Glu Ile Asn Glu Ala Val Pro Gln Val Lys
                  85                  90                  95

 ttt tat gaa gag caa agg gaa cag cag tta att tca gcc gtc ttt cca      336
 Phe Tyr Glu Glu Gln Arg Glu Gln Gln Leu Ile Ser Ala Val Phe Pro
             100                 105                 110

 ttc cat tat acc att tgg agg atc ctc agg ggt aac acc ttt tgg agg      384
 Phe His Tyr Thr Ile Trp Arg Ile Leu Arg Gly Asn Thr Phe Trp Arg
         115                 120                 125

 tgg gca tct tcc tca ttc tca gtg gtg cca agt tca tat cct gct ggc      432
 Trp Ala Ser Ser Ser Phe Ser Val Val Pro Ser Ser Tyr Pro Ala Gly
     130                 135                 140

 tta aca cgt ggt gtt act ata ttt gtg gcc tta tat gat tat gaa gct      480
 Leu Thr Arg Gly Val Thr Ile Phe Val Ala Leu Tyr Asp Tyr Glu Ala
 145                 150                 155                 160

 aga act aca gaa gac ctt tca ttt aag aag ggt gaa aaa ttt caa ata      528
 Arg Thr Thr Glu Asp Leu Ser Phe Lys Lys Gly Glu Lys Phe Gln Ile
                 165                 170                 175

 att aac aat aca gaa gga gac tgg tgg gaa gca aga tca atc act aca      576
 Ile Asn Asn Thr Glu Gly Asp Trp Trp Glu Ala Arg Ser Ile Thr Thr
             180                 185                 190

 gga aag aat ggt tat atc ctg agc agt tat gta gcg cct gca gat tcc      624
 Gly Lys Asn Gly Tyr Ile Leu Ser Ser Tyr Val Ala Pro Ala Asp Ser
         195                 200                 205

 att cag gca gaa gaa tgg tat ttt ggc aaa atg ggg aga aaa gat gct      672
 Ile Gln Ala Glu Glu Trp Tyr Phe Gly Lys Met Gly Arg Lys Asp Ala
     210                 215                 220

 gaa aga tta ctt ctg aat cct gga aat taa                              702
 Glu Arg Leu Leu Leu Asn Pro Gly Asn 
 225                 230





      <210> 778
      <211> 414
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (1)..(414)

      <400> 778
  atg tgg aag cga ctt tgg aca tgg gta ata ggc aga ggc tgg aac agt      48
  Met Trp Lys Arg Leu Trp Thr Trp Val Ile Gly Arg Gly Trp Asn Ser
    1               5                  10                  15

 ttg gag aac tca gaa gaa gac aag aag ata tgg gaa agg ttg gaa ctt       96
 Leu Glu Asn Ser Glu Glu Asp Lys Lys Ile Trp Glu Arg Leu Glu Leu
              20                  25                  30

 cct aga gac ttg ttg aat ggt ttt gat caa aat gct gaa agt gat atg      144
 Pro Arg Asp Leu Leu Asn Gly Phe Asp Gln Asn Ala Glu Ser Asp Met
          35                  40                  45

 gaa aat gaa atg aag tcc agg ccg aga tca tcc tgg att gtg ctg gtg      192
 Glu Asn Glu Met Lys Ser Arg Pro Arg Ser Ser Trp Ile Val Leu Val
      50                  55                  60

 gtc cct aaa tcc aat gaa aaa gga aaa atc cat aaa aag agg aga aga      240
 Val Pro Lys Ser Asn Glu Lys Gly Lys Ile His Lys Lys Arg Arg Arg
  65                  70                  75                  80

 cag ata cag aca gag cct tat gaa gaa gca att atg aag ttt tgc ttg      288
 Gln Ile Gln Thr Glu Pro Tyr Glu Glu Ala Ile Met Lys Phe Cys Leu
                  85                  90                  95

 gaa cta gga cac cag gta tgt cag tct ctg ggc ccc agt ggt ggc agt      336
 Glu Leu Gly His Gln Val Cys Gln Ser Leu Gly Pro Ser Gly Gly Ser
             100                 105                 110

 tgt ggg ttg agt gtt ctt att ctt aga tca gga gca gct gat agt gac      384
 Cys Gly Leu Ser Val Leu Ile Leu Arg Ser Gly Ala Ala Asp Ser Asp
         115                 120                 125

 act gtt gtt agt gaa tcc tgg agg tct tag                              414
 Thr Val Val Ser Glu Ser Trp Arg Ser 
     130                 135





      <210> 779
      <211> 1374
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (1)..(1374)

      <400> 779
  atg aag gtt gca ttc cct gca gag gct cta ggg gag aat ctc ctt tgc      48
  Met Lys Val Ala Phe Pro Ala Glu Ala Leu Gly Glu Asn Leu Leu Cys
    1               5                  10                  15

 ctt ttc cat ctt ctg aaa gct gcc tac gtt cct ctg ctc ctt atc acc       96
 Leu Phe His Leu Leu Lys Ala Ala Tyr Val Pro Leu Leu Leu Ile Thr
              20                  25                  30

 ccc cac ccc acc cca cct tac tgt att ttc aaa gcc agc aac ata gta      144
 Pro His Pro Thr Pro Pro Tyr Cys Ile Phe Lys Ala Ser Asn Ile Val
          35                  40                  45

 tct tta gat ctc ctt cgc ttg cct ggt gta tcg cag cac ttt ggg agg      192
 Ser Leu Asp Leu Leu Arg Leu Pro Gly Val Ser Gln His Phe Gly Arg
      50                  55                  60

 ctg aga act gta gaa gat ttg aaa aat aat gaa agc caa tgg aaa gat      240
 Leu Arg Thr Val Glu Asp Leu Lys Asn Asn Glu Ser Gln Trp Lys Asp
  65                  70                  75                  80

 tcc cca ctg gca act aga cac cgc gaa atg ctg aag cgc tgt aaa act      288
 Ser Pro Leu Ala Thr Arg His Arg Glu Met Leu Lys Arg Cys Lys Thr
                  85                  90                  95

 cag ctt aag aaa ctg gta cgg tgc aag gcc tgt gct gat gct ggc cta      336
 Gln Leu Lys Lys Leu Val Arg Cys Lys Ala Cys Ala Asp Ala Gly Leu
             100                 105                 110

 ctt gac gag agc ttc ctg aga aga tgt ctg aat ttt tat ggc ctt ctc      384
 Leu Asp Glu Ser Phe Leu Arg Arg Cys Leu Asn Phe Tyr Gly Leu Leu
         115                 120                 125

 att cag ctg ctg ctc cgc atc ctg gac ccc gca tat ccc gat ata aca      432
 Ile Gln Leu Leu Leu Arg Ile Leu Asp Pro Ala Tyr Pro Asp Ile Thr
     130                 135                 140

 ctg cct tta aat tca gat gtc ccc aag gta ttt gca gcg ttg cct gag      480
 Leu Pro Leu Asn Ser Asp Val Pro Lys Val Phe Ala Ala Leu Pro Glu
 145                 150                 155                 160

 ttt tat gta gaa gat gtt gca gaa ttt tta ttt ttt att gta caa tac      528
 Phe Tyr Val Glu Asp Val Ala Glu Phe Leu Phe Phe Ile Val Gln Tyr
                 165                 170                 175

 tct ccc cag gcg ctt tat gag ccc tgt act cag gat att gtg atg ttc      576
 Ser Pro Gln Ala Leu Tyr Glu Pro Cys Thr Gln Asp Ile Val Met Phe
             180                 185                 190

 ctt gtt gtg atg ttg tgc aac cag aac tac atc cga aac cca tat ttg      624
 Leu Val Val Met Leu Cys Asn Gln Asn Tyr Ile Arg Asn Pro Tyr Leu
         195                 200                 205

 gtg gcc aaa ctg gta gaa gtc atg ttt atg acc aac cct gct gtt cag      672
 Val Ala Lys Leu Val Glu Val Met Phe Met Thr Asn Pro Ala Val Gln
     210                 215                 220

 cca cga acc cag aag ttt ttt gaa atg att gag aac cat cct ctc tcc      720
 Pro Arg Thr Gln Lys Phe Phe Glu Met Ile Glu Asn His Pro Leu Ser
 225                 230                 235                 240

 acc aag ttg ttg gta cct tcc ctg atg aag ttt tat aca gat gtt gag      768
 Thr Lys Leu Leu Val Pro Ser Leu Met Lys Phe Tyr Thr Asp Val Glu
                 245                 250                 255

 cat acc gga gcc acc agt gag ttt tat gac aag ttc aca att cgc tat      816
 His Thr Gly Ala Thr Ser Glu Phe Tyr Asp Lys Phe Thr Ile Arg Tyr
             260                 265                 270

 cat att agc acc att ttt aaa agc ctt tgg caa aac ata gct cac cat      864
 His Ile Ser Thr Ile Phe Lys Ser Leu Trp Gln Asn Ile Ala His His
         275                 280                 285

 ggc acc ttt atg gag gag ttc aag ctc att ctt gac cag gga acg gca      912
 Gly Thr Phe Met Glu Glu Phe Lys Leu Ile Leu Asp Gln Gly Thr Ala
     290                 295                 300

 ggc ccc cca gta tcc ctg cag aat ctc cat caa gca cag act gga gca      960
 Gly Pro Pro Val Ser Leu Gln Asn Leu His Gln Ala Gln Thr Gly Ala
 305                 310                 315                 320

 ctt tcc cag agg gca ctc acc ggc cag ctt cag ctc tgc cag ctg tgt     1008
 Leu Ser Gln Arg Ala Leu Thr Gly Gln Leu Gln Leu Cys Gln Leu Cys
                 325                 330                 335

 tcc ttt ccc aac aag aaa agg cct ctg aac aga tcc cat ggc aga gtt     1056
 Ser Phe Pro Asn Lys Lys Arg Pro Leu Asn Arg Ser His Gly Arg Val
             340                 345                 350

 gaa gga gga aag tgc gcc aga ggt aag cgt gct gac agt tct gtg gat     1104
 Glu Gly Gly Lys Cys Ala Arg Gly Lys Arg Ala Asp Ser Ser Val Asp
         355                 360                 365

 cag cag cag gct cgt cag tct cag ctt gct cag gat gag cgt gtg tcc     1152
 Gln Gln Gln Ala Arg Gln Ser Gln Leu Ala Gln Asp Glu Arg Val Ser
     370                 375                 380

 cgc tct tac ctc gcc ctg gcc acc gaa acc gtg gac atg ttc cac atc     1200
 Arg Ser Tyr Leu Ala Leu Ala Thr Glu Thr Val Asp Met Phe His Ile
 385                 390                 395                 400

 ctc acg aag cag gtc cag aag ccc ttc ctc aga ccg ctt atg ata cac     1248
 Leu Thr Lys Gln Val Gln Lys Pro Phe Leu Arg Pro Leu Met Ile His
                 405                 410                 415

 agc acc tgt aag gat tct ttg aag att aat cca acc aat tcc tgt tcc     1296
 Ser Thr Cys Lys Asp Ser Leu Lys Ile Asn Pro Thr Asn Ser Cys Ser
             420                 425                 430

 tcc act gaa atg gga gtt ttt ggt cct ttt cac ttg tct caa cag cat     1344
 Ser Thr Glu Met Gly Val Phe Gly Pro Phe His Leu Ser Gln Gln His
         435                 440                 445

 gaa ttg tcc tat tat cct gtg att tcc tag                             1374
 Glu Leu Ser Tyr Tyr Pro Val Ile Ser 
     450                 455





      <210> 780
      <211> 384
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (1)..(384)

      <400> 780
  atg gcc ctg gct gct gtg tgc ctc gcc ctg gtg aga ccg tgt aag atg      48
  Met Ala Leu Ala Ala Val Cys Leu Ala Leu Val Arg Pro Cys Lys Met
    1               5                  10                  15

 gga ctg tgc cag cat cat cac tca ggt gaa aca aag gta gtg agc cat       96
 Gly Leu Cys Gln His His His Ser Gly Glu Thr Lys Val Val Ser His
              20                  25                  30

 cgt ggg aag act tta cag gac ata cct gaa gac ttt ctg gaa atg gat      144
 Arg Gly Lys Thr Leu Gln Asp Ile Pro Glu Asp Phe Leu Glu Met Asp
          35                  40                  45

 ctt gca aaa aat gag cac aga gtt cac gtg caa atg gag ccg ctc aag      192
 Leu Ala Lys Asn Glu His Arg Val His Val Gln Met Glu Pro Leu Lys
      50                  55                  60

 aga gtc ttt gct gct atg aaa cag ctg gat aac cac agg aca ctg aaa      240
 Arg Val Phe Ala Ala Met Lys Gln Leu Asp Asn His Arg Thr Leu Lys
  65                  70                  75                  80

 gca ctg tgc cga gaa ccc acc ggt tca gca tct gag gat gga tgg atc      288
 Ala Leu Cys Arg Glu Pro Thr Gly Ser Ala Ser Glu Asp Gly Trp Ile
                  85                  90                  95

 tca gac tgc cca gca gta gtg tac tac atg ggt ggg tca gtt gta aag      336
 Ser Asp Cys Pro Ala Val Val Tyr Tyr Met Gly Gly Ser Val Val Lys
             100                 105                 110

 aag aaa aaa ctg atc cat gag cag aca cta aag aaa aca gtg gga tga      384
 Lys Lys Lys Leu Ile His Glu Gln Thr Leu Lys Lys Thr Val Gly 
         115                 120                 125





      <210> 781
      <211> 432
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (1)..(432)

      <400> 781
  atg ctc atc acg ctt tcg ttg atg gga gca tat gtt ccc atc aaa gcc      48
  Met Leu Ile Thr Leu Ser Leu Met Gly Ala Tyr Val Pro Ile Lys Ala
    1               5                  10                  15

 atg aag tcc att cct gtt ccc act gac tgt tct cct cac aca ccc aca       96
 Met Lys Ser Ile Pro Val Pro Thr Asp Cys Ser Pro His Thr Pro Thr
              20                  25                  30

 ggt ctg gaa gat tgc ttc gtc tcc aag agt tgc ctt gag tgc act gcc      144
 Gly Leu Glu Asp Cys Phe Val Ser Lys Ser Cys Leu Glu Cys Thr Ala
          35                  40                  45

 tgg ttc tgt ccc ctc gat ctt ggc aaa gtt acc ttt cac gtc aga gag      192
 Trp Phe Cys Pro Leu Asp Leu Gly Lys Val Thr Phe His Val Arg Glu
      50                  55                  60

 aag cag tac tac gag atg ctt tac aac aca gct gac gag ctc ctg aac      240
 Lys Gln Tyr Tyr Glu Met Leu Tyr Asn Thr Ala Asp Glu Leu Leu Asn
  65                  70                  75                  80

 ctg gtg gtg gac cag ggt gtg aag tac acg gag ctg gag tac atc cac      288
 Leu Val Val Asp Gln Gly Val Lys Tyr Thr Glu Leu Glu Tyr Ile His
                  85                  90                  95

 gct ctg acc ctg ctg cac cgc agc cag act ggg gtg ggg gaa ctg acc      336
 Ala Leu Thr Leu Leu His Arg Ser Gln Thr Gly Val Gly Glu Leu Thr
             100                 105                 110

 acc cag aac acg agg ctg cag agg ctc aaa gag atc atc tgc gag cag      384
 Thr Gln Asn Thr Arg Leu Gln Arg Leu Lys Glu Ile Ile Cys Glu Gln
         115                 120                 125

 gct gcc atc aag caa gcc acc aag gac aag aag ata act acc gtt tag      432
 Ala Ala Ile Lys Gln Ala Thr Lys Asp Lys Lys Ile Thr Thr Val 
     130                 135                 140





      <210> 782
      <211> 2343
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (1)..(2343)

      <400> 782
  atg gca ctg gga ggg ctc act gcc tgc acg gtg gtg ctg acc aca gtc      48
  Met Ala Leu Gly Gly Leu Thr Ala Cys Thr Val Val Leu Thr Thr Val
    1               5                  10                  15

 atg tgc tcc aag gcc att aag aat aac act tct atg gac gct cag cac       96
 Met Cys Ser Lys Ala Ile Lys Asn Asn Thr Ser Met Asp Ala Gln His
              20                  25                  30

 aca ggg gcc gct cag aag cat gtc acc tta aaa gcc atc tgg tgg gca      144
 Thr Gly Ala Ala Gln Lys His Val Thr Leu Lys Ala Ile Trp Trp Ala
          35                  40                  45

 aaa cca gat cca cat gca cag cgc atg gaa ggc agg aag tcc cac gac      192
 Lys Pro Asp Pro His Ala Gln Arg Met Glu Gly Arg Lys Ser His Asp
      50                  55                  60

 acc cag aca tgc acc aca ggc cac cag ctc ctg caa gag cac att ccg      240
 Thr Gln Thr Cys Thr Thr Gly His Gln Leu Leu Gln Glu His Ile Pro
  65                  70                  75                  80

 cag cgc agt cag cat ggt acc acc atc gcc atc acc atc gcc tcc agt      288
 Gln Arg Ser Gln His Gly Thr Thr Ile Ala Ile Thr Ile Ala Ser Ser
                  85                  90                  95

 ggg cct gga gga tcc tgg ggc aag ctt cac tta gtc ttg gca gca tac      336
 Gly Pro Gly Gly Ser Trp Gly Lys Leu His Leu Val Leu Ala Ala Tyr
             100                 105                 110

 ttc aag tct gcc gtg ccc cag tgc tac cct gtc cca gct tcg gca gct      384
 Phe Lys Ser Ala Val Pro Gln Cys Tyr Pro Val Pro Ala Ser Ala Ala
         115                 120                 125

 gcc ccc agg cag gac act ggc cca cag cca tcc tgt gtc acc cac agg      432
 Ala Pro Arg Gln Asp Thr Gly Pro Gln Pro Ser Cys Val Thr His Arg
     130                 135                 140

 acg cac aag gag atg gtg gcc tca tcc ctg act cca gag gca ttt gct      480
 Thr His Lys Glu Met Val Ala Ser Ser Leu Thr Pro Glu Ala Phe Ala
 145                 150                 155                 160

 gac tcc cta gat ggt ccc tgt ttc tgg tct gat gga gac tcc tgc ctg      528
 Asp Ser Leu Asp Gly Pro Cys Phe Trp Ser Asp Gly Asp Ser Cys Leu
                 165                 170                 175

 atg gcc ctt gcc ggc ccc tgc ccc tcc tcc act gct tcc ctt ctc ccc      576
 Met Ala Leu Ala Gly Pro Cys Pro Ser Ser Thr Ala Ser Leu Leu Pro
             180                 185                 190

 tcc acc caa gcc ttg ccc aca att aac tca ttt ctt aag atc gct tcc      624
 Ser Thr Gln Ala Leu Pro Thr Ile Asn Ser Phe Leu Lys Ile Ala Ser
         195                 200                 205

 aaa cct aag tca acg ctg gac agg gct gta gga aaa gct tcc tca ata      672
 Lys Pro Lys Ser Thr Leu Asp Arg Ala Val Gly Lys Ala Ser Ser Ile
     210                 215                 220

 ctg gcc ctg aag agc cga gcc agc gcc aag agg agt gtg ctg ctc ccc      720
 Leu Ala Leu Lys Ser Arg Ala Ser Ala Lys Arg Ser Val Leu Leu Pro
 225                 230                 235                 240

 atc ctg gca ctg tgg gcg ggg agc tgc tca gga ggg gcc cca cca acc      768
 Ile Leu Ala Leu Trp Ala Gly Ser Cys Ser Gly Gly Ala Pro Pro Thr
                 245                 250                 255

 ccc atg ggc ttg gct acc ctg cag ctg ctg ccc agc cca cca ggg gcc      816
 Pro Met Gly Leu Ala Thr Leu Gln Leu Leu Pro Ser Pro Pro Gly Ala
             260                 265                 270

 ccc gac ggt cag ctg cag ccc atc cct ggc atc ggc cac cca gac aag      864
 Pro Asp Gly Gln Leu Gln Pro Ile Pro Gly Ile Gly His Pro Asp Lys
         275                 280                 285

 cct gag gct ggg aag ctg gac cag ttg cgg gat cag ccc acc ccg aag      912
 Pro Glu Ala Gly Lys Leu Asp Gln Leu Arg Asp Gln Pro Thr Pro Lys
     290                 295                 300

 cag gga gct caa gga acc ccc acc cag tcc ccc tcc act ggc tgg aaa      960
 Gln Gly Ala Gln Gly Thr Pro Thr Gln Ser Pro Ser Thr Gly Trp Lys
 305                 310                 315                 320

 gcg ctt ccc agg cca ggg ctg gcc ctg agg aag gag tca ccc cca gtg     1008
 Ala Leu Pro Arg Pro Gly Leu Ala Leu Arg Lys Glu Ser Pro Pro Val
                 325                 330                 335

 acc ttg gag cag gag cag ggt cac aac aag ggc ctg gtc gct gag tgg     1056
 Thr Leu Glu Gln Glu Gln Gly His Asn Lys Gly Leu Val Ala Glu Trp
             340                 345                 350

 gct cag ccc cag gcc aca gct gcc atg agg gct ggg gca ggg aag ccc     1104
 Ala Gln Pro Gln Ala Thr Ala Ala Met Arg Ala Gly Ala Gly Lys Pro
         355                 360                 365

 gag gcc ttg aag ctg agg ccc tgg cag gcc ggc agg gac cct caa gct     1152
 Glu Ala Leu Lys Leu Arg Pro Trp Gln Ala Gly Arg Asp Pro Gln Ala
     370                 375                 380

 caa gag ggg gca gca gtc acc gag gag gac cag ggc cag agg aca gga     1200
 Gln Glu Gly Ala Ala Val Thr Glu Glu Asp Gln Gly Gln Arg Thr Gly
 385                 390                 395                 400

 ggc cgg gaa gac aag gga agg ggc ctg aaa ccc agg agg ccc ccc aaa     1248
 Gly Arg Glu Asp Lys Gly Arg Gly Leu Lys Pro Arg Arg Pro Pro Lys
                 405                 410                 415

 ggg acc tcc cat caa cct ggg ctg agg atc cgg cgc cca cag aag gac     1296
 Gly Thr Ser His Gln Pro Gly Leu Arg Ile Arg Arg Pro Gln Lys Asp
             420                 425                 430

 cgc agc cga ggc cag ggt ggc ggc ggc agc acc tcc aag acc cca ggc     1344
 Arg Ser Arg Gly Gln Gly Gly Gly Gly Ser Thr Ser Lys Thr Pro Gly
         435                 440                 445

 cat ggg tgg aaa aga cca gga agc aca cat ggg cac agg cac agg cac     1392
 His Gly Trp Lys Arg Pro Gly Ser Thr His Gly His Arg His Arg His
     450                 455                 460

 gca gac ctg ggc acc acc cag cag gcc atg ccc tct ctg ccg gcc tcg     1440
 Ala Asp Leu Gly Thr Thr Gln Gln Ala Met Pro Ser Leu Pro Ala Ser
 465                 470                 475                 480

 tgc ctc ctg gcc cag gca gtc atc gcc tgt ggc aat gtc aag atg aag     1488
 Cys Leu Leu Ala Gln Ala Val Ile Ala Cys Gly Asn Val Lys Met Lys
                 485                 490                 495

 cat gtc cct gcc ctg acc cac cct ggt ctg acc aca ctc tac ctg gca     1536
 His Val Pro Ala Leu Thr His Pro Gly Leu Thr Thr Leu Tyr Leu Ala
             500                 505                 510

 gag aat gaa att gcc aag atc cca gcc cac acg ttc ctg ggg ctg ccc     1584
 Glu Asn Glu Ile Ala Lys Ile Pro Ala His Thr Phe Leu Gly Leu Pro
         515                 520                 525

 aac ctg gag tgg ctg gat ctc agc aag aac aag ctg gat ccc cga ggc     1632
 Asn Leu Glu Trp Leu Asp Leu Ser Lys Asn Lys Leu Asp Pro Arg Gly
     530                 535                 540

 ctg cac ccc cat gcc ttc aag aat ctg atg cgg ctg aag cgg ctg aac     1680
 Leu His Pro His Ala Phe Lys Asn Leu Met Arg Leu Lys Arg Leu Asn
 545                 550                 555                 560

 ctg gtt ggg aac tcg ctg acc aca gtc ccg gcc cta cct gcc tcc ctg     1728
 Leu Val Gly Asn Ser Leu Thr Thr Val Pro Ala Leu Pro Ala Ser Leu
                 565                 570                 575

 cag gag ctc aaa ctc aac gac aac ctc ctg cag ggc ttg caa ggc agc     1776
 Gln Glu Leu Lys Leu Asn Asp Asn Leu Leu Gln Gly Leu Gln Gly Ser
             580                 585                 590

 agc ttc cgt gga gtt gcc aac cgt cag ctc cct ctg ccc ctg tgt gcc     1824
 Ser Phe Arg Gly Val Ala Asn Arg Gln Leu Pro Leu Pro Leu Cys Ala
         595                 600                 605

 ccg ccc cac agg aag ctg gag acc ctt gac ctg tcc tac aac cgg ctg     1872
 Pro Pro His Arg Lys Leu Glu Thr Leu Asp Leu Ser Tyr Asn Arg Leu
     610                 615                 620

 gtg cac gtg ccc cgc ttc ctg ccg cgg ggc ctg agg cgc ctg acg ctg     1920
 Val His Val Pro Arg Phe Leu Pro Arg Gly Leu Arg Arg Leu Thr Leu
 625                 630                 635                 640

 cac cac gac cac atc gag cgc atc cct ggc tac gcg ttc gcg cac atg     1968
 His His Asp His Ile Glu Arg Ile Pro Gly Tyr Ala Phe Ala His Met
                 645                 650                 655

 aag cca ggc cta gag ttc ctg cac ctg tcc cac aac agg ctg cag gct     2016
 Lys Pro Gly Leu Glu Phe Leu His Leu Ser His Asn Arg Leu Gln Ala
             660                 665                 670

 gac ggc atc cac agc gtg tcc ttc ctg ggc ctg cgc gcc tcg ctg gcg     2064
 Asp Gly Ile His Ser Val Ser Phe Leu Gly Leu Arg Ala Ser Leu Ala
         675                 680                 685

 gag ctg ctc ctg gat cat aac cag gtg cag gcc atc cca cgc ggc ctc     2112
 Glu Leu Leu Leu Asp His Asn Gln Val Gln Ala Ile Pro Arg Gly Leu
     690                 695                 700

 ctg ggc ctc aag gga ctg cag gtg ctg ggc ctg agc cac aac agg atc     2160
 Leu Gly Leu Lys Gly Leu Gln Val Leu Gly Leu Ser His Asn Arg Ile
 705                 710                 715                 720

 aga caa gtg ccc ttg aat tcc atc tgt gac atg cgc gtg gct cag gac     2208
 Arg Gln Val Pro Leu Asn Ser Ile Cys Asp Met Arg Val Ala Gln Asp
                 725                 730                 735

 tcc aac ctt acc tcc aca cac ctg gag aac aac ctc att gac cgg cgc     2256
 Ser Asn Leu Thr Ser Thr His Leu Glu Asn Asn Leu Ile Asp Arg Arg
             740                 745                 750

 cgc atc ccg ccc act gcc ttc tcc tgc acc cga gcc tat cac agc gtg     2304
 Arg Ile Pro Pro Thr Ala Phe Ser Cys Thr Arg Ala Tyr His Ser Val
         755                 760                 765

 gtc ctc cag ccc cag cgg cgg ggg gag gag ggc tcc tag                 2343
 Val Leu Gln Pro Gln Arg Arg Gly Glu Glu Gly Ser 
     770                 775                 780





      <210> 783
      <211> 665
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (129)..(665)

      <400> 783
 ttgccagatg tcctcagtct ctacggcttc tgcattccgg tcccttcctc ttagaggggc     60

 tcctttctaa cagcaggctc ctgctgttca gttcatctga aaagaaggaa ttgctagctc    120

 agacagag atg ttg agt gtc ctc aca aca tgg cag cca gtt ttc ctg agt     170
          Met Leu Ser Val Leu Thr Thr Trp Gln Pro Val Phe Leu Ser
            1               5                  10

 gac cga tcc aag aga aag cac agg gtg gtg gtt tcc tat cct cct cag      218
 Asp Arg Ser Lys Arg Lys His Arg Val Val Val Ser Tyr Pro Pro Gln
  15                  20                  25                  30

 agt gag gca gaa ctt gaa ctt aaa gaa gga gat att gtg ttt gtt cat      266
 Ser Glu Ala Glu Leu Glu Leu Lys Glu Gly Asp Ile Val Phe Val His
                  35                  40                  45

 aaa aaa cga gag gat ggc tgg ttc aaa ggc aca tta caa cga caa aat      314
 Lys Lys Arg Glu Asp Gly Trp Phe Lys Gly Thr Leu Gln Arg Gln Asn
              50                  55                  60

 gga gaa gta ccc aga act gtg ttt ctg ctt tgc agc aca aaa aca tcc      362
 Gly Glu Val Pro Arg Thr Val Phe Leu Leu Cys Ser Thr Lys Thr Ser
          65                  70                  75

 cgg gag cca gac aat tct ttg ctg atc ctc aaa gat agc aag tcc aga      410
 Arg Glu Pro Asp Asn Ser Leu Leu Ile Leu Lys Asp Ser Lys Ser Arg
      80                  85                  90

 cca cag att tgt gtg tct caa att gca aag cat gtt cct ctg ccc tcc      458
 Pro Gln Ile Cys Val Ser Gln Ile Ala Lys His Val Pro Leu Pro Ser
  95                 100                 105                 110

 tgg aag cct ggg ttg aga gag atg cga ctc gtt cag cag ccc gtc tat      506
 Trp Lys Pro Gly Leu Arg Glu Met Arg Leu Val Gln Gln Pro Val Tyr
                 115                 120                 125

 gct cag ggt aag ccc gag cac gtc agc gaa gtc tcc ctg gca tgg gat      554
 Ala Gln Gly Lys Pro Glu His Val Ser Glu Val Ser Leu Ala Trp Asp
             130                 135                 140

 ccg gca tcc ggg aag cta aga ggc atc agt ggg gca agc tgg gat ggt      602
 Pro Ala Ser Gly Lys Leu Arg Gly Ile Ser Gly Ala Ser Trp Asp Gly
         145                 150                 155

 tcc aat ggc cca tgg cct cct ctc agc ttt acc cca cct cac ccc aac      650
 Ser Asn Gly Pro Trp Pro Pro Leu Ser Phe Thr Pro Pro His Pro Asn
     160                 165                 170

 cag aga gat cag tag                                                  665
 Gln Arg Asp Gln 
 175





      <210> 784
      <211> 912
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (1)..(912)

      <400> 784
  atg ccc caa agc cac cag tgg gcc ttt cct ctt tgc caa cta aag ctt      48
  Met Pro Gln Ser His Gln Trp Ala Phe Pro Leu Cys Gln Leu Lys Leu
    1               5                  10                  15

 aca ttc ctg agc ctg acc gtc aaa gcc ttc cag gac cta gcc ttt atc       96
 Thr Phe Leu Ser Leu Thr Val Lys Ala Phe Gln Asp Leu Ala Phe Ile
              20                  25                  30

 tgc atc ttg gaa tat gtc agc aag tca gtt tac ttg aag act gtg att      144
 Cys Ile Leu Glu Tyr Val Ser Lys Ser Val Tyr Leu Lys Thr Val Ile
          35                  40                  45

 aat caa agc tat aat gta gca gat aca gtt att aat atc aac aag cta      192
 Asn Gln Ser Tyr Asn Val Ala Asp Thr Val Ile Asn Ile Asn Lys Leu
      50                  55                  60

 aga aat atg gaa tgc aac tta ggt caa gac aat gag cct gcc aag gct      240
 Arg Asn Met Glu Cys Asn Leu Gly Gln Asp Asn Glu Pro Ala Lys Ala
  65                  70                  75                  80

 cct gga ctt ccc act agt ctg cca gtg cct gga gca ccc aca gct gca      288
 Pro Gly Leu Pro Thr Ser Leu Pro Val Pro Gly Ala Pro Thr Ala Ala
                  85                  90                  95

 cag gaa gct gct gtg ccc ggc tac ctc cag gtc ccc gca ccg ggt cgg      336
 Gln Glu Ala Ala Val Pro Gly Tyr Leu Gln Val Pro Ala Pro Gly Arg
             100                 105                 110

 caa ggt gca gca gcc ccc aaa ccc agg ctc cga ata ttc ccc aag cgc      384
 Gln Gly Ala Ala Ala Pro Lys Pro Arg Leu Arg Ile Phe Pro Lys Arg
         115                 120                 125

 gct gag ttc cgt tcc cct ccg ccc tgc gga ggg cgc ccc aca aat gcg      432
 Ala Glu Phe Arg Ser Pro Pro Pro Cys Gly Gly Arg Pro Thr Asn Ala
     130                 135                 140

 gac agg acg ccc ctc gtt ctg ccc tgt cgg act ccc cca cgt ctt ggt      480
 Asp Arg Thr Pro Leu Val Leu Pro Cys Arg Thr Pro Pro Arg Leu Gly
 145                 150                 155                 160

 cct gaa tct ccc gcc ctc cgg gct cag cct tcc caa cat cgc ggt ccc      528
 Pro Glu Ser Pro Ala Leu Arg Ala Gln Pro Ser Gln His Arg Gly Pro
                 165                 170                 175

 cac acc ccc gcc agc tct cca ggc tca ggc tcc atg act ccc cag cat      576
 His Thr Pro Ala Ser Ser Pro Gly Ser Gly Ser Met Thr Pro Gln His
             180                 185                 190

 cgc agt cct ggc cac ccc act aca gcc gtt cag agc tcc agg gct ccc      624
 Arg Ser Pro Gly His Pro Thr Thr Ala Val Gln Ser Ser Arg Ala Pro
         195                 200                 205

 cag cat cct aac ccg tcg tcc ccc ctt ccg ggc ttg gat tcg gag act      672
 Gln His Pro Asn Pro Ser Ser Pro Leu Pro Gly Leu Asp Ser Glu Thr
     210                 215                 220

 caa cat cgg ggc cct aaa ctc cgg ccc ctg gcc tca gcc cgc gcc gct      720
 Gln His Arg Gly Pro Lys Leu Arg Pro Leu Ala Ser Ala Arg Ala Ala
 225                 230                 235                 240

 gcc gcc gct gcg agg aag ttg act gac gcc gct tcc ttc cac cca gga      768
 Ala Ala Ala Ala Arg Lys Leu Thr Asp Ala Ala Ser Phe His Pro Gly
                 245                 250                 255

 cgc aga ccc tcg cag tcc ctg gta gct gca aaa aat ccg gag agt ttg      816
 Arg Arg Pro Ser Gln Ser Leu Val Ala Ala Lys Asn Pro Glu Ser Leu
             260                 265                 270

 aga cag aga cgc ctt aac cgc cct cat att ctt tcc aag aat tca cct      864
 Arg Gln Arg Arg Leu Asn Arg Pro His Ile Leu Ser Lys Asn Ser Pro
         275                 280                 285

 ctc agg ggg cca ttt ccg aag tcc ctc ggg aag ggc gga aaa caa taa      912
 Leu Arg Gly Pro Phe Pro Lys Ser Leu Gly Lys Gly Gly Lys Gln 
     290                 295                 300





      <210> 785
      <211> 924
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (1)..(924)

      <400> 785
  atg cag atg gaa aaa cgg gag ctt tca gag gcg gaa gtt ttg gaa gtg      48
  Met Gln Met Glu Lys Arg Glu Leu Ser Glu Ala Glu Val Leu Glu Val
    1               5                  10                  15

 cag ttc cag ttg aaa gtt ggg ata gtc agt ttg atc atc tgg ttt ctg       96
 Gln Phe Gln Leu Lys Val Gly Ile Val Ser Leu Ile Ile Trp Phe Leu
              20                  25                  30

 ata ctc aag gtg tgg cca tta att gca gca tgg gca tca cct ggg ggc      144
 Ile Leu Lys Val Trp Pro Leu Ile Ala Ala Trp Ala Ser Pro Gly Gly
          35                  40                  45

 ttg tta gag gca gaa tct cag gtt ctc cct cag acc tgt gaa tca gaa      192
 Leu Leu Glu Ala Glu Ser Gln Val Leu Pro Gln Thr Cys Glu Ser Glu
      50                  55                  60

 ctt gca ttg aaa gaa gat cct aag ata acc cgc atg cac att aca ttt      240
 Leu Ala Leu Lys Glu Asp Pro Lys Ile Thr Arg Met His Ile Thr Phe
  65                  70                  75                  80

 gga gaa gtt ctg ctc aag agc gtt tcc caa agt gta ttc tgc gga act      288
 Gly Glu Val Leu Leu Lys Ser Val Ser Gln Ser Val Phe Cys Gly Thr
                  85                  90                  95

 agc acc tac tgt gtt ctc aac acc gtg cca cct ata gaa gat gat cat      336
 Ser Thr Tyr Cys Val Leu Asn Thr Val Pro Pro Ile Glu Asp Asp His
             100                 105                 110

 ggg aac agc aat agt agt cat gta aaa atc ttt tta ccg aaa aag ctg      384
 Gly Asn Ser Asn Ser Ser His Val Lys Ile Phe Leu Pro Lys Lys Leu
         115                 120                 125

 ctt gaa tgt ctg ccg aaa tgt tca agt tta cca aaa gag agg cac cgc      432
 Leu Glu Cys Leu Pro Lys Cys Ser Ser Leu Pro Lys Glu Arg His Arg
     130                 135                 140

 tgg aac act aat gag cag cag cag cag cag cag cac tcc aca gga tat      480
 Trp Asn Thr Asn Glu Gln Gln Gln Gln Gln Gln His Ser Thr Gly Tyr
 145                 150                 155                 160

 att gaa aag ctg ggg cgg aat gtc ctc cca cac aga gcc gca gtt gag      528
 Ile Glu Lys Leu Gly Arg Asn Val Leu Pro His Arg Ala Ala Val Glu
                 165                 170                 175

 aaa cac tgc tct ctt gga aag ggt gca gag ctg gtg tca gaa gca gat      576
 Lys His Cys Ser Leu Gly Lys Gly Ala Glu Leu Val Ser Glu Ala Asp
             180                 185                 190

 tcg agt ctt ggc tct gcc gct act cag ctg agt gtt ggt ctg tct cca      624
 Ser Ser Leu Gly Ser Ala Ala Thr Gln Leu Ser Val Gly Leu Ser Pro
         195                 200                 205

 tct ttg agc tgc tgt tct ttc tac agc tta agg ttc tta gat gtc cat      672
 Ser Leu Ser Cys Cys Ser Phe Tyr Ser Leu Arg Phe Leu Asp Val His
     210                 215                 220

 tcc att ccc tac cca gtc ttg gaa cac tgt gag atg agc att cct gat      720
 Ser Ile Pro Tyr Pro Val Leu Glu His Cys Glu Met Ser Ile Pro Asp
 225                 230                 235                 240

 aag tgg tca tcc aat ttg gaa aga cag tat ttt aca agg tct gct ggc      768
 Lys Trp Ser Ser Asn Leu Glu Arg Gln Tyr Phe Thr Arg Ser Ala Gly
                 245                 250                 255

 cag cag ctg atg gtc cag ggg ctt ctg ttc gct gac aag gcc ggc agt      816
 Gln Gln Leu Met Val Gln Gly Leu Leu Phe Ala Asp Lys Ala Gly Ser
             260                 265                 270

 tgg ggg aaa aag cta gtg aca gaa gca gca cgt gga caa gct gga acc      864
 Trp Gly Lys Lys Leu Val Thr Glu Ala Ala Arg Gly Gln Ala Gly Thr
         275                 280                 285

 ctc tgg cat ctc cgt tta tat ctg cta cca cct cta act acc tcg gcc      912
 Leu Trp His Leu Arg Leu Tyr Leu Leu Pro Pro Leu Thr Thr Ser Ala
     290                 295                 300

 ctc agg aag taa                                                      924
 Leu Arg Lys 
 305





      <210> 786
      <211> 651
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (495)..(651)

      <400> 786
 atgacggcgc tgctgcagtg cgtcttcgca cttacgcgga gcggccacag actggtacca     60

 gtcagtggcc tgttaggaac cgagctgcac aagaggagaa tcatgactct caatgttgaa    120

 gaatgggcta ctgcatggaa gggaaagctt caggtcttgg accagcgtga agttcagcag    180

 gtggcccagc gcagatgtgt ccgtgaacca gatggtcaga tggccattgt agctggttcg    240

 ctctactgca aggggcagga cggttttaca gttgcacatc aggttggcca aactgtagtc    300

 acaatcccgg atgtccgcag aacagctgca gttccgaatg gtgttttccc ttgtgaagat    360

 gagcgtgctg ttcttctgac ctttggtgaa gcagttaagt gcaaagacac ccagagtgct    420

 gatcagaaga agacagtgcc tggaagcaca ctgttggact tcatttctga gcttctggta    480

 gtgaagtggt acca  tgt gat tga gtt ctg gcc aat gga ata tgg tgg aag     530
                  Met Val Pro Leu His Tyr Gln Lys Leu Arg Asn Glu
                    1               5                  10

 att cca cga agg aac cga cgg ccc tag aag atg gca gaa ctg tag aca      578
 Val Gln Gln Cys Ala Ser Arg His Cys Leu Leu Leu Ile Ser Thr Leu
          15                  20                  25

 aaa ggc tga atc cct gaa tga ttg tat gaa aga gag cac acc cct ctt      626
 Gly Val Phe Ala Leu Asn Cys Phe Thr Lys Gly Gln Lys Asn Ser Thr
      30                  35                  40

 ccc cct taa tgg cat tag tct gtg a                                    651
 Leu Ile Phe Thr Arg Glu Asn Thr Ile Arg Asn Cys Ser Cys Ser Ala 
  45                  50                  55                  60





      <210> 787
      <211> 1143
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (1)..(1143)

      <400> 787
  atg gaa tgc ctg cgc agt tta ccc tgc ctc ctg ccc cgc gcg atg aga      48
  Met Glu Cys Leu Arg Ser Leu Pro Cys Leu Leu Pro Arg Ala Met Arg
    1               5                  10                  15

 ctt ccc cgg cgg acg ctg tgt gcc ctg gcc ttg gac gtg acc tct gtg       96
 Leu Pro Arg Arg Thr Leu Cys Ala Leu Ala Leu Asp Val Thr Ser Val
              20                  25                  30

 ggt cct ccc gtt gct gcc tgc ggc cgc cga gcc aac ctg att gga agg      144
 Gly Pro Pro Val Ala Ala Cys Gly Arg Arg Ala Asn Leu Ile Gly Arg
          35                  40                  45

 agc cga gcg gcg cag ctt tgc ggg ccc gac cgg ctc cgc gtg gca gaa      192
 Ser Arg Ala Ala Gln Leu Cys Gly Pro Asp Arg Leu Arg Val Ala Glu
      50                  55                  60

 agg aag aaa act gaa tta tac caa gag tta ggt ctt caa gcc aga gat      240
 Arg Lys Lys Thr Glu Leu Tyr Gln Glu Leu Gly Leu Gln Ala Arg Asp
  65                  70                  75                  80

 ttg aga ttt cag cat gta atg agt atc aca gtc aga aac aat agg att      288
 Leu Arg Phe Gln His Val Met Ser Ile Thr Val Arg Asn Asn Arg Ile
                  85                  90                  95

 atc atg aga atg gag tat ttg aaa gct gtg ata act cca gag tgt ctt      336
 Ile Met Arg Met Glu Tyr Leu Lys Ala Val Ile Thr Pro Glu Cys Leu
             100                 105                 110

 ctg ata tta gat tat cgt aat tta aac tta gag caa tgg ctg ttc cgg      384
 Leu Ile Leu Asp Tyr Arg Asn Leu Asn Leu Glu Gln Trp Leu Phe Arg
         115                 120                 125

 gaa ctc cct tca cag ttg tct gga gag ggt caa ctc gtt aca tac cct      432
 Glu Leu Pro Ser Gln Leu Ser Gly Glu Gly Gln Leu Val Thr Tyr Pro
     130                 135                 140

 tta cct ttt gag ttt aga gct ata gaa gca ctc ctg caa tat tgg aat      480
 Leu Pro Phe Glu Phe Arg Ala Ile Glu Ala Leu Leu Gln Tyr Trp Asn
 145                 150                 155                 160

 aga tgg cta cac ttc ctg ctt ggg gta att aat gag cac cag cta gca      528
 Arg Trp Leu His Phe Leu Leu Gly Val Ile Asn Glu His Gln Leu Ala
                 165                 170                 175

 cca gcc agt gag atg ata agt agt ggg agc cca gtt acc aag cag ggg      576
 Pro Ala Ser Glu Met Ile Ser Ser Gly Ser Pro Val Thr Lys Gln Gly
             180                 185                 190

 gaa agc aga aga gag aaa gaa gat gta aac agt ggt aag tca tgg gct      624
 Glu Ser Arg Arg Glu Lys Glu Asp Val Asn Ser Gly Lys Ser Trp Ala
         195                 200                 205

 cca cag gct ggt cta tca gag tta gaa aca gat att aaa att ttc aaa      672
 Pro Gln Ala Gly Leu Ser Glu Leu Glu Thr Asp Ile Lys Ile Phe Lys
     210                 215                 220

 gag tca att ttg gag atc ttg gat gag gaa gag ttg cta gaa gag ctc      720
 Glu Ser Ile Leu Glu Ile Leu Asp Glu Glu Glu Leu Leu Glu Glu Leu
 225                 230                 235                 240

 tgt gta tca aaa tgg agt gac cca caa gtc ttt gaa aag agc agt gct      768
 Cys Val Ser Lys Trp Ser Asp Pro Gln Val Phe Glu Lys Ser Ser Ala
                 245                 250                 255

 ggg att gac cat gca gaa gaa atg gag ttg ctg ttg gaa aac tac tac      816
 Gly Ile Asp His Ala Glu Glu Met Glu Leu Leu Leu Glu Asn Tyr Tyr
             260                 265                 270

 cga ttg gct gac gat ctc tcc aat gca gct cgt gag ctt agg gtg ctg      864
 Arg Leu Ala Asp Asp Leu Ser Asn Ala Ala Arg Glu Leu Arg Val Leu
         275                 280                 285

 att gat gat tca caa agt att att ttc att aat ctg gac agc cac cga      912
 Ile Asp Asp Ser Gln Ser Ile Ile Phe Ile Asn Leu Asp Ser His Arg
     290                 295                 300

 aac gtg atg atg agg ttg aat cta cag ctg acc atg gga acc ttc tct      960
 Asn Val Met Met Arg Leu Asn Leu Gln Leu Thr Met Gly Thr Phe Ser
 305                 310                 315                 320

 ctt tcg ctc ttt gga cta atg gga gtt gct ttt gga atg aat ttg gaa     1008
 Leu Ser Leu Phe Gly Leu Met Gly Val Ala Phe Gly Met Asn Leu Glu
                 325                 330                 335

 tct tcc ctt gaa gag gac cat aga att ttt tgg ctg att aca gga att     1056
 Ser Ser Leu Glu Glu Asp His Arg Ile Phe Trp Leu Ile Thr Gly Ile
             340                 345                 350

 atg ttc atg gga agt ggc ctc atc tgg agg cgc ctg ctt tca ttc ctt     1104
 Met Phe Met Gly Ser Gly Leu Ile Trp Arg Arg Leu Leu Ser Phe Leu
         355                 360                 365

 gga cga cag cta gaa gct cca ttg cct cct atg gta tga                 1143
 Gly Arg Gln Leu Glu Ala Pro Leu Pro Pro Met Val 
     370                 375                 380





      <210> 788
      <211> 822
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (1)..(822)

      <400> 788
  atg ttg tgt agc cta ttg ctc ttt ggc tgt aaa cct gca ctg cat gtc      48
  Met Leu Cys Ser Leu Leu Leu Phe Gly Cys Lys Pro Ala Leu His Val
    1               5                  10                  15

 act gta ttg aat act ata ggc agc tgt aac aat gaa tgc cag ttg tgt       96
 Thr Val Leu Asn Thr Ile Gly Ser Cys Asn Asn Glu Cys Gln Leu Cys
              20                  25                  30

 ctg cac att ccc agc cct ctc aag ttc ata tcc atc aaa gct gtc agt      144
 Leu His Ile Pro Ser Pro Leu Lys Phe Ile Ser Ile Lys Ala Val Ser
          35                  40                  45

 atg tca tct gta gct tca tct atg tca ttt aca aaa gtg ttg aat tgg      192
 Met Ser Ser Val Ala Ser Ser Met Ser Phe Thr Lys Val Leu Asn Trp
      50                  55                  60

 gat cca tct gtc tct aag tct gta gaa cga atc ttt aaa atc tgg gaa      240
 Asp Pro Ser Val Ser Lys Ser Val Glu Arg Ile Phe Lys Ile Trp Glu
  65                  70                  75                  80

 gat aga aat gta tac cca gaa gaa atg att gtg gca ttg aga gaa gct      288
 Asp Arg Asn Val Tyr Pro Glu Glu Met Ile Val Ala Leu Arg Glu Ala
                  85                  90                  95

 ttg agt acc act ttc aaa act cag aag cag ctg aaa gaa aat ctg aac      336
 Leu Ser Thr Thr Phe Lys Thr Gln Lys Gln Leu Lys Glu Asn Leu Asn
             100                 105                 110

 aaa caa ccg aat aag cag tgg aag aaa tca caa aca tct aca aat cca      384
 Lys Gln Pro Asn Lys Gln Trp Lys Lys Ser Gln Thr Ser Thr Asn Pro
         115                 120                 125

 aaa gct gct ctc aag tct aag ata gtt gct gaa ttt cga tct cag gcc      432
 Lys Ala Ala Leu Lys Ser Lys Ile Val Ala Glu Phe Arg Ser Gln Ala
     130                 135                 140

 cta att gaa gag ctg ttg cta tac aag cgc tca gaa gat cag ata gaa      480
 Leu Ile Glu Glu Leu Leu Leu Tyr Lys Arg Ser Glu Asp Gln Ile Glu
 145                 150                 155                 160

 ctg aag gaa aag cag ttg tca act atg agg gtg gat gtg tgc agc aca      528
 Leu Lys Glu Lys Gln Leu Ser Thr Met Arg Val Asp Val Cys Ser Thr
                 165                 170                 175

 gaa act ctc aaa tgc tta aaa gat aaa aca ggt ggg aag aag ttc tcc      576
 Glu Thr Leu Lys Cys Leu Lys Asp Lys Thr Gly Gly Lys Lys Phe Ser
             180                 185                 190

 aaa gaa ttt gaa gag gca agc tcc aag ctg gaa gaa ttt gtg aat gga      624
 Lys Glu Phe Glu Glu Ala Ser Ser Lys Leu Glu Glu Phe Val Asn Gly
         195                 200                 205

 tta gat aag cag gtg aaa aac gga ccc tca tta aca gaa gca ctg gaa      672
 Leu Asp Lys Gln Val Lys Asn Gly Pro Ser Leu Thr Glu Ala Leu Glu
     210                 215                 220

 aat gct gga att ttc tat gaa gca caa tac aaa gaa gta aaa gtg gtg      720
 Asn Ala Gly Ile Phe Tyr Glu Ala Gln Tyr Lys Glu Val Lys Val Val
 225                 230                 235                 240

 gct aat tgc tgg gat tgc agg tgt gag cca ccg tcc ctg gcc tta ctt      768
 Ala Asn Cys Trp Asp Cys Arg Cys Glu Pro Pro Ser Leu Ala Leu Leu
                 245                 250                 255

 ttt ttc tta acc aga aaa ctg gat gga aac atc ctg tta cca aat ttc      816
 Phe Phe Leu Thr Arg Lys Leu Asp Gly Asn Ile Leu Leu Pro Asn Phe
             260                 265                 270

 atg taa                                                              822
 Met 






      <210> 789
      <211> 846
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (1)..(846)

      <400> 789
  atg agc ctg aaa ttc ttt tac atc ttt tta aca agc tcc ccg agt ttg      48
  Met Ser Leu Lys Phe Phe Tyr Ile Phe Leu Thr Ser Ser Pro Ser Leu
    1               5                  10                  15

 aaa acc act gct gtg agt att gtg cag ata tat gtt gag acc tgt ggt       96
 Lys Thr Thr Ala Val Ser Ile Val Gln Ile Tyr Val Glu Thr Cys Gly
              20                  25                  30

 att caa aga att gat gac att gta aaa gct gtt ggt aac tgc agc tac      144
 Ile Gln Arg Ile Asp Asp Ile Val Lys Ala Val Gly Asn Cys Ser Tyr
          35                  40                  45

 aac caa cta gtg gag aag atc atc tct tgt aaa cag tca gac aat agt      192
 Asn Gln Leu Val Glu Lys Ile Ile Ser Cys Lys Gln Ser Asp Asn Ser
      50                  55                  60

 gag ctg gtt agt gaa ggc ttt gta gct gag cag ttt cta aat aac aca      240
 Glu Leu Val Ser Glu Gly Phe Val Ala Glu Gln Phe Leu Asn Asn Thr
  65                  70                  75                  80

 gcc act caa ctg aca tac cat gga tta tgt gaa cta act tca acg gtt      288
 Ala Thr Gln Leu Thr Tyr His Gly Leu Cys Glu Leu Thr Ser Thr Val
                  85                  90                  95

 cag gaa gga gaa ctt tgt gtg ttc ttt cgg aat aat cat ttt agc acc      336
 Gln Glu Gly Glu Leu Cys Val Phe Phe Arg Asn Asn His Phe Ser Thr
             100                 105                 110

 atg acc aaa tac aag ggt caa ctg tat ttg ttg gta acg gac cag ggg      384
 Met Thr Lys Tyr Lys Gly Gln Leu Tyr Leu Leu Val Thr Asp Gln Gly
         115                 120                 125

 ttt ctt act gaa gag aaa gtt gtt tgg gaa agc cta cac aac gta gat      432
 Phe Leu Thr Glu Glu Lys Val Val Trp Glu Ser Leu His Asn Val Asp
     130                 135                 140

 ggt gat gga aat ttc tgt gac tca gaa ttt cat ctt cga cct cct tca      480
 Gly Asp Gly Asn Phe Cys Asp Ser Glu Phe His Leu Arg Pro Pro Ser
 145                 150                 155                 160

 gat cct gaa act gta tac aaa gga caa caa gat cag ata gat cag gat      528
 Asp Pro Glu Thr Val Tyr Lys Gly Gln Gln Asp Gln Ile Asp Gln Asp
                 165                 170                 175

 tat ctt atg gca tta tct cta caa caa gaa cag cag agc caa gag atc      576
 Tyr Leu Met Ala Leu Ser Leu Gln Gln Glu Gln Gln Ser Gln Glu Ile
             180                 185                 190

 aat tgg gaa caa atc ccg gaa gga atc agt gat ttg gaa cta gca aag      624
 Asn Trp Glu Gln Ile Pro Glu Gly Ile Ser Asp Leu Glu Leu Ala Lys
         195                 200                 205

 aaa ctc caa gag gaa gag gac aga cgg gct tct caa tac tat cag gaa      672
 Lys Leu Gln Glu Glu Glu Asp Arg Arg Ala Ser Gln Tyr Tyr Gln Glu
     210                 215                 220

 cag gaa caa gca gca gct gct gct gct gct gct tct aca cag gct cag      720
 Gln Glu Gln Ala Ala Ala Ala Ala Ala Ala Ala Ser Thr Gln Ala Gln
 225                 230                 235                 240

 ggc cag cca gca caa gcc tct cca tca agt gga aga caa tct ggg aat      768
 Gly Gln Pro Ala Gln Ala Ser Pro Ser Ser Gly Arg Gln Ser Gly Asn
                 245                 250                 255

 agt gaa cgt aaa cgg aag gaa cca cga gaa aaa gat aaa gaa aaa gaa      816
 Ser Glu Arg Lys Arg Lys Glu Pro Arg Glu Lys Asp Lys Glu Lys Glu
             260                 265                 270

 aag gaa aaa aat agc tgt gtt att ttg taa                              846
 Lys Glu Lys Asn Ser Cys Val Ile Leu 
         275                 280





      <210> 790
      <211> 558
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (1)..(558)

      <400> 790
  atg atg tgg ccc atg cac acc cca ctg ctg ctg ctg act gcc ttg atg      48
  Met Met Trp Pro Met His Thr Pro Leu Leu Leu Leu Thr Ala Leu Met
    1               5                  10                  15

 gtg gcc gtg gcc ggg agt gcc tcg gcc caa tct agg acc ttg gca ggt       96
 Val Ala Val Ala Gly Ser Ala Ser Ala Gln Ser Arg Thr Leu Ala Gly
              20                  25                  30

 ggc atc cat gcc aca gac ctc aat gac aag agt gtg cag tgt gcc ctg      144
 Gly Ile His Ala Thr Asp Leu Asn Asp Lys Ser Val Gln Cys Ala Leu
          35                  40                  45

 gac ttt gcc atc agc gag tac aac aag gtc att aat aag gat gag tac      192
 Asp Phe Ala Ile Ser Glu Tyr Asn Lys Val Ile Asn Lys Asp Glu Tyr
      50                  55                  60

 tac agc cgc cct ctg cag gtg atg gct gcc tac cag cag ccc tct ccc      240
 Tyr Ser Arg Pro Leu Gln Val Met Ala Ala Tyr Gln Gln Pro Ser Pro
  65                  70                  75                  80

 tgc aca gga ggg gca ttc cct ggt gct gtg gtc cct gct ggc ctg cac      288
 Cys Thr Gly Gly Ala Phe Pro Gly Ala Val Val Pro Ala Gly Leu His
                  85                  90                  95

 tcc ctc tta agt gtg tca ctc act ggg agt gaa gca cag aat gat gta      336
 Ser Leu Leu Ser Val Ser Leu Thr Gly Ser Glu Ala Gln Asn Asp Val
             100                 105                 110

 gat cgt tgg gcc ctg gag cct att tta cag agc agc aga ctg aca ccg      384
 Asp Arg Trp Ala Leu Glu Pro Ile Leu Gln Ser Ser Arg Leu Thr Pro
         115                 120                 125

 gag gga tca cag gac ttc cat gtg gtt cta cag gac tta acc cat aag      432
 Glu Gly Ser Gln Asp Phe His Val Val Leu Gln Asp Leu Thr His Lys
     130                 135                 140

 gtt cag gca aat gtg gaa cgt tct gtc cag aaa ccc ctt ctc tgt agc      480
 Val Gln Ala Asn Val Glu Arg Ser Val Gln Lys Pro Leu Leu Cys Ser
 145                 150                 155                 160

 tct gtg ctt ctg tgt aaa ggt gga cct aga tcc tcc agg cag tgg gat      528
 Ser Val Leu Leu Cys Lys Gly Gly Pro Arg Ser Ser Arg Gln Trp Asp
                 165                 170                 175

 gtt ctt ctt act cat aag caa agt ttc tga                              558
 Val Leu Leu Thr His Lys Gln Ser Phe 
             180                 185





      <210> 791
      <211> 502
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (98)..(502)

      <400> 791
 gagctgcaca ccccaattct gttgcaaatg gccaaagctg aacctggttg gatatggaga     60

 aggtgaagat tctgaatacc caagaggttt tgtggag atg tta cga cct gaa ttg     115
                                          Met Leu Arg Pro Glu Leu
                                            1               5

 gta gtt aag aag tta cga tat tat gca aga ttt ata gta gtt tgt ctt      163
 Val Val Lys Lys Leu Arg Tyr Tyr Ala Arg Phe Ile Val Val Cys Leu
              10                  15                  20

 ctt ctc aac aaa atg gat gtt gta aag gat ctg gta aag gaa ttg tca      211
 Leu Leu Asn Lys Met Asp Val Val Lys Asp Leu Val Lys Glu Leu Ser
          25                  30                  35

 gat gaa att gaa gat tat act cac cga ttt aat act gaa gat caa gtg      259
 Asp Glu Ile Glu Asp Tyr Thr His Arg Phe Asn Thr Glu Asp Gln Val
      40                  45                  50

 gaa tgg aac ttg gtg ctt caa gaa gta gca gct ttc att gag gcg gat      307
 Glu Trp Asn Leu Val Leu Gln Glu Val Ala Ala Phe Ile Glu Ala Asp
  55                  60                  65                  70

 cct gta atg gta tta aat gat gat aat acc att gtt atc aca tcg aat      355
 Pro Val Met Val Leu Asn Asp Asp Asn Thr Ile Val Ile Thr Ser Asn
                  75                  80                  85

 cgc ctt gct gaa aca gga gcc cca ttg ctg gaa cag ggc atg att gtg      403
 Arg Leu Ala Glu Thr Gly Ala Pro Leu Leu Glu Gln Gly Met Ile Val
              90                  95                 100

 gga cag ttg tct ctg gct gac gca ctc att att ggt aat tgt aat aat      451
 Gly Gln Leu Ser Leu Ala Asp Ala Leu Ile Ile Gly Asn Cys Asn Asn
         105                 110                 115

 cag gta aag aat tgt gaa gga att atg ctt aaa att cac tgt gaa aaa      499
 Gln Val Lys Asn Cys Glu Gly Ile Met Leu Lys Ile His Cys Glu Lys
     120                 125                 130

 tag                                                                  502
 






      <210> 792
      <211> 936
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (1)..(936)

      <400> 792
  atg gct ctc ttc act ccg tgg aag ttg tcc tct cag aag ctg ggc ttt      48
  Met Ala Leu Phe Thr Pro Trp Lys Leu Ser Ser Gln Lys Leu Gly Phe
    1               5                  10                  15

 ttc ctg gtg act ttt ggc ttc att tgg ggt atg atg ctt ctg cac ttt       96
 Phe Leu Val Thr Phe Gly Phe Ile Trp Gly Met Met Leu Leu His Phe
              20                  25                  30

 acc atc cag cag cga act cag cct gaa agc agc tcc atg ctg cgc gag      144
 Thr Ile Gln Gln Arg Thr Gln Pro Glu Ser Ser Ser Met Leu Arg Glu
          35                  40                  45

 cag atc ctg gac ctc agc aaa agg tac atc aag gca ctg gca gaa gaa      192
 Gln Ile Leu Asp Leu Ser Lys Arg Tyr Ile Lys Ala Leu Ala Glu Glu
      50                  55                  60

 aac agg aat gtg gtg gat ggg cca tac gct gga gtc atg aca gct tat      240
 Asn Arg Asn Val Val Asp Gly Pro Tyr Ala Gly Val Met Thr Ala Tyr
  65                  70                  75                  80

 gcc aat aaa tat gac act ggc act tgc atg ctg ggc att ggt ggt ggt      288
 Ala Asn Lys Tyr Asp Thr Gly Thr Cys Met Leu Gly Ile Gly Gly Gly
                  85                  90                  95

 ggt gtt tct ggc atg gta cag caa gca gga agc agt agt gtg cga ggc      336
 Gly Val Ser Gly Met Val Gln Gln Ala Gly Ser Ser Ser Val Arg Gly
             100                 105                 110

 cac cct ttc caa gaa gat ctg aag aaa acc ctt gct gtg tta tta gat      384
 His Pro Phe Gln Glu Asp Leu Lys Lys Thr Leu Ala Val Leu Leu Asp
         115                 120                 125

 aac att ttg cag cgc att ggc aag ttg gag tcg aag gtg gac aat ctt      432
 Asn Ile Leu Gln Arg Ile Gly Lys Leu Glu Ser Lys Val Asp Asn Leu
     130                 135                 140

 gtt gtc aat ggc acc gga aca aac tca acc aac tcc act aca gct gtt      480
 Val Val Asn Gly Thr Gly Thr Asn Ser Thr Asn Ser Thr Thr Ala Val
 145                 150                 155                 160

 ccc agc ttg gtt gca ctt gag aaa att aat gtg gca gct gtg ttc tgt      528
 Pro Ser Leu Val Ala Leu Glu Lys Ile Asn Val Ala Ala Val Phe Cys
                 165                 170                 175

 gta gct ttt atc caa aaa ccg gac ctt gtg aaa ggg ctg tcc aga agc      576
 Val Ala Phe Ile Gln Lys Pro Asp Leu Val Lys Gly Leu Ser Arg Ser
             180                 185                 190

 tac ttg gca gtc aca gcc tgg acc tgg tct ttg gca tca gac att ttt      624
 Tyr Leu Ala Val Thr Ala Trp Thr Trp Ser Leu Ala Ser Asp Ile Phe
         195                 200                 205

 gag cag aac tct ggg tcc act tac ata ctt gct gtt agc att tta tta      672
 Glu Gln Asn Ser Gly Ser Thr Tyr Ile Leu Ala Val Ser Ile Leu Leu
     210                 215                 220

 tac tta acc att gct gac cct ccg att cat gct ctg tgc aat ggc ggt      720
 Tyr Leu Thr Ile Ala Asp Pro Pro Ile His Ala Leu Cys Asn Gly Gly
 225                 230                 235                 240

 agt gac acc aac act gtc ctc atg aaa ctc ttc tca gtt tgg aga atg      768
 Ser Asp Thr Asn Thr Val Leu Met Lys Leu Phe Ser Val Trp Arg Met
                 245                 250                 255

 tgg atc cag aga ttc atg agc ttt tat aag tgg aaa aga ttt aga tgt      816
 Trp Ile Gln Arg Phe Met Ser Phe Tyr Lys Trp Lys Arg Phe Arg Cys
             260                 265                 270

 tct aac att tcc tcc aaa tgg gag att gca act ttc caa aat cct tgg      864
 Ser Asn Ile Ser Ser Lys Trp Glu Ile Ala Thr Phe Gln Asn Pro Trp
         275                 280                 285

 tgg atg gtt ctc cag att tat ctc aac agt tct agt gct gga act ttt      912
 Trp Met Val Leu Gln Ile Tyr Leu Asn Ser Ser Ser Ala Gly Thr Phe
     290                 295                 300

 agc tgc cat act gtt gaa ctt tag                                      936
 Ser Cys His Thr Val Glu Leu 
 305                 310





      <210> 793
      <211> 1122
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (1)..(1122)

      <400> 793
  atg gag gtg gtg ctg atc ttt cta tgc agc ctg ttg gcc cac att gtc      48
  Met Glu Val Val Leu Ile Phe Leu Cys Ser Leu Leu Ala His Ile Val
    1               5                  10                  15

 ctg gcc gat gca gtt gag agg gag aag caa att gac cct ttt cat tat       96
 Leu Ala Asp Ala Val Glu Arg Glu Lys Gln Ile Asp Pro Phe His Tyr
              20                  25                  30

 gac tac cag acc ctg agg att agg ggt tac ttc aat gaa aat gca aag      144
 Asp Tyr Gln Thr Leu Arg Ile Arg Gly Tyr Phe Asn Glu Asn Ala Lys
          35                  40                  45

 aac atc aga tgc tat ttg gac ctc atg atg cag aat gtg ggt cgg acg      192
 Asn Ile Arg Cys Tyr Leu Asp Leu Met Met Gln Asn Val Gly Arg Thr
      50                  55                  60

 gcc cac aag ttg gaa tca ttc atg ctg tac ttc agc ttg gac caa gca      240
 Ala His Lys Leu Glu Ser Phe Met Leu Tyr Phe Ser Leu Asp Gln Ala
  65                  70                  75                  80

 tgt ctg tgc ctt tat gca aac atc aac cac aat ttg tca ctc acc tat      288
 Cys Leu Cys Leu Tyr Ala Asn Ile Asn His Asn Leu Ser Leu Thr Tyr
                  85                  90                  95

 ggt gcc ctt gat cac caa gtc aaa gct ctg aat gtc ctg aga gtg ctc      336
 Gly Ala Leu Asp His Gln Val Lys Ala Leu Asn Val Leu Arg Val Leu
             100                 105                 110

 tgc tac ctg gaa tcc cag gag tgc cag atc acc aca tac tat tat gtt      384
 Cys Tyr Leu Glu Ser Gln Glu Cys Gln Ile Thr Thr Tyr Tyr Tyr Val
         115                 120                 125

 ggg ttt gca tat ttg atg atg tgt cgc tac cag gat gcc atc cgg gtc      432
 Gly Phe Ala Tyr Leu Met Met Cys Arg Tyr Gln Asp Ala Ile Arg Val
     130                 135                 140

 ttt gcc aac agc ctc ctc tac atc cag agg acc aag agc atg ttc cag      480
 Phe Ala Asn Ser Leu Leu Tyr Ile Gln Arg Thr Lys Ser Met Phe Gln
 145                 150                 155                 160

 agg acc aca tac aag tat gag atg att aac aag cag aat gag cag atg      528
 Arg Thr Thr Tyr Lys Tyr Glu Met Ile Asn Lys Gln Asn Glu Gln Met
                 165                 170                 175

 cat gca ctg ctg gcc att gcc ctc acg gtg tac ccc atg agt atc gat      576
 His Ala Leu Leu Ala Ile Ala Leu Thr Val Tyr Pro Met Ser Ile Asp
             180                 185                 190

 gag agc att cac ctc cag ctg cag aag aaa cac agg gac aag atg ctg      624
 Glu Ser Ile His Leu Gln Leu Gln Lys Lys His Arg Asp Lys Met Leu
         195                 200                 205

 cgc atg cag aaa ggt gac cca caa gtc tat gaa gaa ctt ttc agt tac      672
 Arg Met Gln Lys Gly Asp Pro Gln Val Tyr Glu Glu Leu Phe Ser Tyr
     210                 215                 220

 ttc tgc ccc aag ttc ctg tcg cct gta gtg ccc aac tat gat aat gtg      720
 Phe Cys Pro Lys Phe Leu Ser Pro Val Val Pro Asn Tyr Asp Asn Val
 225                 230                 235                 240

 cac ccc aac tac cac aaa gag ccc ttc ctg cag cag ctg aag gtg ttt      768
 His Pro Asn Tyr His Lys Glu Pro Phe Leu Gln Gln Leu Lys Val Phe
                 245                 250                 255

 tct gat gaa gta cag cag cag gcc cag ctt tca acc atc cac agc ttc      816
 Ser Asp Glu Val Gln Gln Gln Ala Gln Leu Ser Thr Ile His Ser Phe
             260                 265                 270

 ctc aag ctc tac acc acc atg cct gtg gcc aag ctg gct ggc ttc ctg      864
 Leu Lys Leu Tyr Thr Thr Met Pro Val Ala Lys Leu Ala Gly Phe Leu
         275                 280                 285

 gac ctc aca gag cag gag ttc agg atc cag ctt ctt gtc ttc aaa cac      912
 Asp Leu Thr Glu Gln Glu Phe Arg Ile Gln Leu Leu Val Phe Lys His
     290                 295                 300

 aag atg aag aac ctg gtg tgg acc agc ggc atc tca atc ctg gat ggt      960
 Lys Met Lys Asn Leu Val Trp Thr Ser Gly Ile Ser Ile Leu Asp Gly
 305                 310                 315                 320

 gaa ttt cag tca gcc tca gag gtt gac ttc tac att gat aag gac atg     1008
 Glu Phe Gln Ser Ala Ser Glu Val Asp Phe Tyr Ile Asp Lys Asp Met
                 325                 330                 335

 atc cac atc gcg gac acc aag gtc tcc agg cgc tat ggg gat ttc ttc     1056
 Ile His Ile Ala Asp Thr Lys Val Ser Arg Arg Tyr Gly Asp Phe Phe
             340                 345                 350

 atc cgt cgg atc caa aaa ttg gag gag ctt aat cga acc ctg aag aag     1104
 Ile Arg Arg Ile Gln Lys Leu Glu Glu Leu Asn Arg Thr Leu Lys Lys
         355                 360                 365

 atg gga cag aga ccc tga                                             1122
 Met Gly Gln Arg Pro 
     370





      <210> 794
      <211> 696
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (1)..(696)

      <400> 794
  atg gat cag aga tgg aag ctc act tcg aaa ttc acg cat atc cac aac      48
  Met Asp Gln Arg Trp Lys Leu Thr Ser Lys Phe Thr His Ile His Asn
    1               5                  10                  15

 tat gct ttg ctg tgt acc att ctg ttc ctg gcc acc tac aga gaa aaa       96
 Tyr Ala Leu Leu Cys Thr Ile Leu Phe Leu Ala Thr Tyr Arg Glu Lys
              20                  25                  30

 gtc ttg gtg gca tgc cac agt ttg gac act gca cag caa tgc gta cca      144
 Val Leu Val Ala Cys His Ser Leu Asp Thr Ala Gln Gln Cys Val Pro
          35                  40                  45

 gac acc agg tat ctg ggg agc tac caa gaa gaa atg aat aca gaa gga      192
 Asp Thr Arg Tyr Leu Gly Ser Tyr Gln Glu Glu Met Asn Thr Glu Gly
      50                  55                  60

 gag gag gag tgt act ttg gat ata atc gtg atc acg caa gaa ttc ctg      240
 Glu Glu Glu Cys Thr Leu Asp Ile Ile Val Ile Thr Gln Glu Phe Leu
  65                  70                  75                  80

 tct tca agg tgg ctc ata tct tat acg gta gat cta gag gac agt aca      288
 Ser Ser Arg Trp Leu Ile Ser Tyr Thr Val Asp Leu Glu Asp Ser Thr
                  85                  90                  95

 atc ata act aag att cgc aat ttg gaa cta cat cat gac aag atc ctc      336
 Ile Ile Thr Lys Ile Arg Asn Leu Glu Leu His His Asp Lys Ile Leu
             100                 105                 110

 aat aat cac aga aag aac ttt ttc aga tac agt acc cca tac gat gca      384
 Asn Asn His Arg Lys Asn Phe Phe Arg Tyr Ser Thr Pro Tyr Asp Ala
         115                 120                 125

 aac caa tac cca aag aat aaa gga gag aac gca cag cag cac gag gaa      432
 Asn Gln Tyr Pro Lys Asn Lys Gly Glu Asn Ala Gln Gln His Glu Glu
     130                 135                 140

 ggt act atc ttt atc acc aat gta cgg gat aaa gcc att aag aaa ttc      480
 Gly Thr Ile Phe Ile Thr Asn Val Arg Asp Lys Ala Ile Lys Lys Phe
 145                 150                 155                 160

 gtc att caa aac aca gtg gag gcc aca gca gtc agg gac att tct gaa      528
 Val Ile Gln Asn Thr Val Glu Ala Thr Ala Val Arg Asp Ile Ser Glu
                 165                 170                 175

 gcg agc atc ttc gac gcc tat gtg ctt ccc aag atg tat gtg aag cta      576
 Ala Ser Ile Phe Asp Ala Tyr Val Leu Pro Lys Met Tyr Val Lys Leu
             180                 185                 190

 aat tac tgt ccg aac gca gcc gaa gga agc cga ctc cta gtg gag agt      624
 Asn Tyr Cys Pro Asn Ala Ala Glu Gly Ser Arg Leu Leu Val Glu Ser
         195                 200                 205

 agg ccg aac tca acc gaa gag agc cga gtc cga gag gac ggc agc cag      672
 Arg Pro Asn Ser Thr Glu Glu Ser Arg Val Arg Glu Asp Gly Ser Gln
     210                 215                 220

 ccg aac gta gcc gag gag agc tga                                      696
 Pro Asn Val Ala Glu Glu Ser 
 225                 230





      <210> 795
      <211> 3117
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (214)..(3117)

      <400> 795
 caccagcacc agtacctgga gctggcacat tccctgcgca accacacgga gctgcagagg     60

 gcctgggcca ccatcggccg cacccacctg gacatctatg accactgcca gtcgagggat    120

 gctttgctgc aggcacaggc tgcctttgag aagagcttgg ctattgtgga tgaggagctg    180

 gaggggacac tggcccaggg agagctgaat gag atg agg acc cgc ctc tat ctc     234
                                      Met Arg Thr Arg Leu Tyr Leu
                                        1               5

 aac ctg ggc ctc acc ttt gag agc ctg cag cag aca gcc ctg tgc aac      282
 Asn Leu Gly Leu Thr Phe Glu Ser Leu Gln Gln Thr Ala Leu Cys Asn
          10                  15                  20

 gat tac ttc agg aag agc atc ttc ctt gcg gag cag aac cac ctt tac      330
 Asp Tyr Phe Arg Lys Ser Ile Phe Leu Ala Glu Gln Asn His Leu Tyr
      25                  30                  35

 gag gac cta ttc cgc gcc cgc tac aac ctg ggc acc atc cac tgg cgc      378
 Glu Asp Leu Phe Arg Ala Arg Tyr Asn Leu Gly Thr Ile His Trp Arg
  40                  45                  50                  55

 gcg ggc cag cac tcc cag gct atg cgc tgc ttg gag ggt gcc cgg gag      426
 Ala Gly Gln His Ser Gln Ala Met Arg Cys Leu Glu Gly Ala Arg Glu
                  60                  65                  70

 tgt gcg cac acc atg agg aag cgg ttc atg gag agc gag tgc tgc gtg      474
 Cys Ala His Thr Met Arg Lys Arg Phe Met Glu Ser Glu Cys Cys Val
              75                  80                  85

 gtt att gca cag gta ccc gct gtg cgt ggc tcc gag ctc agg ctc tcg      522
 Val Ile Ala Gln Val Pro Ala Val Arg Gly Ser Glu Leu Arg Leu Ser
          90                  95                 100

 tcc tcc aag acc tgg gag act ttt ttg gct gcc aag cga gcc ctg aag      570
 Ser Ser Lys Thr Trp Glu Thr Phe Leu Ala Ala Lys Arg Ala Leu Lys
     105                 110                 115

 aag gcc tac agg ctg ggc tcc cag aag cct gtg cag agg gca gcc atc      618
 Lys Ala Tyr Arg Leu Gly Ser Gln Lys Pro Val Gln Arg Ala Ala Ile
 120                 125                 130                 135

 tgt cag aac ctc cag cat gtg ctg gca gtg gtc cgg ctg cag caa cag      666
 Cys Gln Asn Leu Gln His Val Leu Ala Val Val Arg Leu Gln Gln Gln
                 140                 145                 150

 ctg gaa gag gct gag ggc aga gac cct cag ggt gcc atg gtc atc tgt      714
 Leu Glu Glu Ala Glu Gly Arg Asp Pro Gln Gly Ala Met Val Ile Cys
             155                 160                 165

 gag cag cta ggg gac ctc ttc tcc aag gca gga gac ttt ccc agg gca      762
 Glu Gln Leu Gly Asp Leu Phe Ser Lys Ala Gly Asp Phe Pro Arg Ala
         170                 175                 180

 gct gag gct tac cag aag cag ctg cgt ttt gct gag ctg ctg gac aga      810
 Ala Glu Ala Tyr Gln Lys Gln Leu Arg Phe Ala Glu Leu Leu Asp Arg
     185                 190                 195

 ccg ggt gct gag cgg gcc atc atc cac gtg tcc ctg gcc acc aca ctg      858
 Pro Gly Ala Glu Arg Ala Ile Ile His Val Ser Leu Ala Thr Thr Leu
 200                 205                 210                 215

 gga gac atg aag gac cac cat ggg gcc gtg cgc cac tat gag gag gaa      906
 Gly Asp Met Lys Asp His His Gly Ala Val Arg His Tyr Glu Glu Glu
                 220                 225                 230

 ctg agg ctg cgc agc ggc aac gtg ctg gag gag gcc aag acc tgg ctg      954
 Leu Arg Leu Arg Ser Gly Asn Val Leu Glu Glu Ala Lys Thr Trp Leu
             235                 240                 245

 aac att gca ctg tcc cgc gag gag gcc ggc gat gcc tac gag ctg ctg     1002
 Asn Ile Ala Leu Ser Arg Glu Glu Ala Gly Asp Ala Tyr Glu Leu Leu
         250                 255                 260

 gcc ccg tgc ttc cag aaa gcg ctc agc tgt gcc cag cag gcc cag cgt     1050
 Ala Pro Cys Phe Gln Lys Ala Leu Ser Cys Ala Gln Gln Ala Gln Arg
     265                 270                 275

 ccc cag ctg cag agg cag gtc ttg cag cat ctc cat acc gtg cag ctg     1098
 Pro Gln Leu Gln Arg Gln Val Leu Gln His Leu His Thr Val Gln Leu
 280                 285                 290                 295

 agg ctg cag ccc cag gag gcc cct gag acc gaa acc aga ctg cgg gag     1146
 Arg Leu Gln Pro Gln Glu Ala Pro Glu Thr Glu Thr Arg Leu Arg Glu
                 300                 305                 310

 ctc agt gta gct gaa gat gaa gat gag gag gag gag gcg gag gag gcg     1194
 Leu Ser Val Ala Glu Asp Glu Asp Glu Glu Glu Glu Ala Glu Glu Ala
             315                 320                 325

 gca gcc aca gcg gag agc gaa gcc ctg gag gcc ggc gag atg gag ctc     1242
 Ala Ala Thr Ala Glu Ser Glu Ala Leu Glu Ala Gly Glu Met Glu Leu
         330                 335                 340

 tca gag ggc gag gac gac acc gat ggc ctg acc ccg cag ctg gag gag     1290
 Ser Glu Gly Glu Asp Asp Thr Asp Gly Leu Thr Pro Gln Leu Glu Glu
     345                 350                 355

 gac gag gag ctt cag ggc cac ctg ggc cgg cgg aag ggg agc aag tgg     1338
 Asp Glu Glu Leu Gln Gly His Leu Gly Arg Arg Lys Gly Ser Lys Trp
 360                 365                 370                 375

 aac cgg cga aac gac atg ggg gag acc ctg ctg cac cga gcc tgc atc     1386
 Asn Arg Arg Asn Asp Met Gly Glu Thr Leu Leu His Arg Ala Cys Ile
                 380                 385                 390

 gag ggc cag ctg cgc cgc gtc cag gac ctt gtg agg cag ggc cac ccc     1434
 Glu Gly Gln Leu Arg Arg Val Gln Asp Leu Val Arg Gln Gly His Pro
             395                 400                 405

 ctt aac cct cgg gac tac tgt ggc tgg aca cct ctg cac gag gcc tgc     1482
 Leu Asn Pro Arg Asp Tyr Cys Gly Trp Thr Pro Leu His Glu Ala Cys
         410                 415                 420

 aac tac ggg cat cta gaa att gtc cgc ttc ctg ctg gac cac ggg gcc     1530
 Asn Tyr Gly His Leu Glu Ile Val Arg Phe Leu Leu Asp His Gly Ala
     425                 430                 435

 gca gtg gac gac cca ggt ggc cag ggc tgc gaa ggc atc acc ccc ctc     1578
 Ala Val Asp Asp Pro Gly Gly Gln Gly Cys Glu Gly Ile Thr Pro Leu
 440                 445                 450                 455

 cac gat gcc ctc aac tgt ggc cac ttc gag gtg gct gag ctg ctg ctt     1626
 His Asp Ala Leu Asn Cys Gly His Phe Glu Val Ala Glu Leu Leu Leu
                 460                 465                 470

 gaa cgg ggg gcg tcc gtc acc ctc cgc act cga aag ggc ctc agc ccg     1674
 Glu Arg Gly Ala Ser Val Thr Leu Arg Thr Arg Lys Gly Leu Ser Pro
             475                 480                 485

 ctg gag acg ctg cag cag tgg gtg aag ctg tac cgc agg gac ctg gac     1722
 Leu Glu Thr Leu Gln Gln Trp Val Lys Leu Tyr Arg Arg Asp Leu Asp
         490                 495                 500

 ctg gag acg cgg cag aag gcc agg gcc atg gag atg ctg ctc cag gcg     1770
 Leu Glu Thr Arg Gln Lys Ala Arg Ala Met Glu Met Leu Leu Gln Ala
     505                 510                 515

 gct gcc tcg ggc caa ggc aag cag ggc gtc cct tgt ccc tgg ggt tgc     1818
 Ala Ala Ser Gly Gln Gly Lys Gln Gly Val Pro Cys Pro Trp Gly Cys
 520                 525                 530                 535

 tgt gcc tac gct gag agt ccc cgg gcc ctg att tcg gga gat gct cca     1866
 Cys Ala Tyr Ala Glu Ser Pro Arg Ala Leu Ile Ser Gly Asp Ala Pro
                 540                 545                 550

 tca cag gca gcg ctc atc ccg gag gag gag tgc ctg gct ggg gac tgg     1914
 Ser Gln Ala Ala Leu Ile Pro Glu Glu Glu Cys Leu Ala Gly Asp Trp
             555                 560                 565

 ctg gag ctg gac atg ccc ctg acc cgc agc cgc cgg ccc cgc ccc cgg     1962
 Leu Glu Leu Asp Met Pro Leu Thr Arg Ser Arg Arg Pro Arg Pro Arg
         570                 575                 580

 ggc act gga gac aac cgc agg ccc agt agt acc tct ggc agt gac acc     2010
 Gly Thr Gly Asp Asn Arg Arg Pro Ser Ser Thr Ser Gly Ser Asp Thr
     585                 590                 595

 cac tct gtg gcc tgg ctg gcc gag cag gcg gcc cag cgc tac tac cag     2058
 His Ser Val Ala Trp Leu Ala Glu Gln Ala Ala Gln Arg Tyr Tyr Gln
 600                 605                 610                 615

 acc tgc ggg ctg ctg ccc agg ctc acc cta cgg aaa gag ggg gcc ctg     2106
 Thr Cys Gly Leu Leu Pro Arg Leu Thr Leu Arg Lys Glu Gly Ala Leu
                 620                 625                 630

 ctg gcc cca cag gac ctc atc cct gat gtg ctg cag agc aat gac gag     2154
 Leu Ala Pro Gln Asp Leu Ile Pro Asp Val Leu Gln Ser Asn Asp Glu
             635                 640                 645

 gtg ttg gct gag gtg act tcg tgg gac ctg ccc cca ttg act gac cgc     2202
 Val Leu Ala Glu Val Thr Ser Trp Asp Leu Pro Pro Leu Thr Asp Arg
         650                 655                 660

 tac cgc agg gcc tgc cag agc ctg ggg caa ggg gag cac caa cag gtg     2250
 Tyr Arg Arg Ala Cys Gln Ser Leu Gly Gln Gly Glu His Gln Gln Val
     665                 670                 675

 ctg cag gcc gtg gag ctc cag ggc ttg ggc ctc tcg ttc agc gcc tgc     2298
 Leu Gln Ala Val Glu Leu Gln Gly Leu Gly Leu Ser Phe Ser Ala Cys
 680                 685                 690                 695

 tcc ctg gcc ctg gac cag gcc cag ctt aca ccc ctg ctg cgg gcc ctc     2346
 Ser Leu Ala Leu Asp Gln Ala Gln Leu Thr Pro Leu Leu Arg Ala Leu
                 700                 705                 710

 aag ctg cac aca gca ctc cgg gag ctg cgc ctg gca ggg aac cgg ctg     2394
 Lys Leu His Thr Ala Leu Arg Glu Leu Arg Leu Ala Gly Asn Arg Leu
             715                 720                 725

 ggg gac aag tgt gtg gct gag ctg gtg gct gcc ctg ggc acc atg ccc     2442
 Gly Asp Lys Cys Val Ala Glu Leu Val Ala Ala Leu Gly Thr Met Pro
         730                 735                 740

 agc ctg gcc ctc ctt gac ctc tcc tcc aat cac ctg ggt ccc gaa ggc     2490
 Ser Leu Ala Leu Leu Asp Leu Ser Ser Asn His Leu Gly Pro Glu Gly
     745                 750                 755

 ctg cgc cag ctt gcc atg ggg ctc cca ggc caa gcc acc ttg cag agt     2538
 Leu Arg Gln Leu Ala Met Gly Leu Pro Gly Gln Ala Thr Leu Gln Ser
 760                 765                 770                 775

 ttg gag gag ctg gac tta agc atg aac ccc ctg ggg gac ggc tgt ggc     2586
 Leu Glu Glu Leu Asp Leu Ser Met Asn Pro Leu Gly Asp Gly Cys Gly
                 780                 785                 790

 cag tcc ctg gcc tcc ctc ctg cac gcc tgc ccc tta ctc agc acc ctg     2634
 Gln Ser Leu Ala Ser Leu Leu His Ala Cys Pro Leu Leu Ser Thr Leu
             795                 800                 805

 cgc ctg cag gcg tgt ggc ttc ggc ccc agc ttc ttt ctg agc cac cag     2682
 Arg Leu Gln Ala Cys Gly Phe Gly Pro Ser Phe Phe Leu Ser His Gln
         810                 815                 820

 aca gca ctg ggt agt gct ttc caa gat gct gag cac ctg aag acc ctg     2730
 Thr Ala Leu Gly Ser Ala Phe Gln Asp Ala Glu His Leu Lys Thr Leu
     825                 830                 835

 tcc ctg tcc tac aac gcc ctg gga gcc cct gcc ctg gcc agg acc ctg     2778
 Ser Leu Ser Tyr Asn Ala Leu Gly Ala Pro Ala Leu Ala Arg Thr Leu
 840                 845                 850                 855

 cag agc ctg ccc gcc ggc acc ctc ctg cac tta gag ctc agc tcc gtg     2826
 Gln Ser Leu Pro Ala Gly Thr Leu Leu His Leu Glu Leu Ser Ser Val
                 860                 865                 870

 gca gcc ggc aag ggt gat tcg gac ctc atg gag cct gta ttc cga tac     2874
 Ala Ala Gly Lys Gly Asp Ser Asp Leu Met Glu Pro Val Phe Arg Tyr
             875                 880                 885

 ctg gcc aag ggc cag gcc gcc ttt tcc agg aag gcc ccc gag tgc tgg     2922
 Leu Ala Lys Gly Gln Ala Ala Phe Ser Arg Lys Ala Pro Glu Cys Trp
         890                 895                 900

 tgc tgc gcc gtc cag ggt ccc ctg ggc ctg ggc ctg tgg gac aag ata     2970
 Cys Cys Ala Val Gln Gly Pro Leu Gly Leu Gly Leu Trp Asp Lys Ile
     905                 910                 915

 gcc gcg cag ctc cgg gaa ctg cag ctg tgc agc aga cgc ctc tgc gct     3018
 Ala Ala Gln Leu Arg Glu Leu Gln Leu Cys Ser Arg Arg Leu Cys Ala
 920                 925                 930                 935

 gag gac agg gac gcc ctg cgc cag ctg cag ccc agt cgg ccg ggc ccc     3066
 Glu Asp Arg Asp Ala Leu Arg Gln Leu Gln Pro Ser Arg Pro Gly Pro
                 940                 945                 950

 ggc gag tgc acg ctg gac cac ggc tcc aag ctc ttc ttt cgg cgc ctc     3114
 Gly Glu Cys Thr Leu Asp His Gly Ser Lys Leu Phe Phe Arg Arg Leu
             955                 960                 965

 tga                                                                 3117
 






      <210> 796
      <211> 641
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (96)..(641)

      <400> 796
 gctcatatgg ttattggcag gattcagttt ctcatggggc gttggacaag ggcctcagtt     60

 cttcgctgac tgttgcccac tctcagttcc ttgaa   atg tgc ctc ttc agt gtg     113
                                          Met Cys Leu Phe Ser Val
                                            1               5

 gca gtg ttc ttc atc gaa gca tgc aag cca caa ggc ccc agg gag agc      161
 Ala Val Phe Phe Ile Glu Ala Cys Lys Pro Gln Gly Pro Arg Glu Ser
              10                  15                  20

 cag caa gat ggc agt cac gct agt ctt caa agc ata aca cca gta gcc      209
 Gln Gln Asp Gly Ser His Ala Ser Leu Gln Ser Ile Thr Pro Val Ala
          25                  30                  35

 ttc aca gcc agc ggc ctt gta ggt gaa gca agc tat tgg tac agg tcc      257
 Phe Thr Ala Ser Gly Leu Val Gly Glu Ala Ser Tyr Trp Tyr Arg Ser
      40                  45                  50

 aca ttg cct agt gct gtg gct gga agg agt cag ttt aat gcg agg caa      305
 Thr Leu Pro Ser Ala Val Ala Gly Arg Ser Gln Phe Asn Ala Arg Gln
  55                  60                  65                  70

 acc acg ttt atc aac aca gag gtc aca aga tac ttt ata cag gag cat      353
 Thr Thr Phe Ile Asn Thr Glu Val Thr Arg Tyr Phe Ile Gln Glu His
                  75                  80                  85

 tcc cac tgg cat cag gtc agt gcc cct ctg gga tgg agc tcc cag agg      401
 Ser His Trp His Gln Val Ser Ala Pro Leu Gly Trp Ser Ser Gln Arg
              90                  95                 100

 aag gag caa gca gcc atc ttt gct gtt ctg cag cct gca ttg gtg atg      449
 Lys Glu Gln Ala Ala Ile Phe Ala Val Leu Gln Pro Ala Leu Val Met
         105                 110                 115

 cct cca gca agg gca cag aac tgg gct gag gct gag atg gat gaa ctg      497
 Pro Pro Ala Arg Ala Gln Asn Trp Ala Glu Ala Glu Met Asp Glu Leu
     120                 125                 130

 aca gaa gta ggc ttc aga agg tgg gta ata acg aac ttc act gag cta      545
 Thr Glu Val Gly Phe Arg Arg Trp Val Ile Thr Asn Phe Thr Glu Leu
 135                 140                 145                 150

 aag gag cat ctt cta acc caa tgc aaa gaa gct aag aac cct gat aaa      593
 Lys Glu His Leu Leu Thr Gln Cys Lys Glu Ala Lys Asn Pro Asp Lys
                 155                 160                 165

 aca tta aac aag ctg tta acc aga ata agc agt tta gtg gga aca taa      641
 Thr Leu Asn Lys Leu Leu Thr Arg Ile Ser Ser Leu Val Gly Thr 
             170                 175                 180





      <210> 797
      <211> 1596
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (1)..(1596)

      <400> 797
  atg cag tgt ggg ctt ggc gtg tcc gtg cta gga atg tcc ctc tta tca      48
  Met Gln Cys Gly Leu Gly Val Ser Val Leu Gly Met Ser Leu Leu Ser
    1               5                  10                  15

 cca cgg tgt gtg tca gtt cac aaa ctg cac aaa tca agc caa gta gct       96
 Pro Arg Cys Val Ser Val His Lys Leu His Lys Ser Ser Gln Val Ala
              20                  25                  30

 ggc gtc tct ggg aac ctg gcc ccg ggc aac cag cca gag aag gag ggc      144
 Gly Val Ser Gly Asn Leu Ala Pro Gly Asn Gln Pro Glu Lys Glu Gly
          35                  40                  45

 cgg gcg cac cag tgc ctg gag tgt gac cgc gcc ttc tca tcg gcg gcg      192
 Arg Ala His Gln Cys Leu Glu Cys Asp Arg Ala Phe Ser Ser Ala Ala
      50                  55                  60

 gtg ctc atg cac cac agc aag gag gtg cat ggc cgg gag cgc atc cac      240
 Val Leu Met His His Ser Lys Glu Val His Gly Arg Glu Arg Ile His
  65                  70                  75                  80

 ggc tgc ccc gtg tgc agg aag gcc ttc aag cgc gcc acg cac ctc aag      288
 Gly Cys Pro Val Cys Arg Lys Ala Phe Lys Arg Ala Thr His Leu Lys
                  85                  90                  95

 ggt aag cct aac tgc acc ctt cga gga gtg cag ctc gtc ggt att tct      336
 Gly Lys Pro Asn Cys Thr Leu Arg Gly Val Gln Leu Val Gly Ile Ser
             100                 105                 110

 ttt aaa gtc atc agc ata gag tgg cag ctg cgt gca ctg ttc cca ccg      384
 Phe Lys Val Ile Ser Ile Glu Trp Gln Leu Arg Ala Leu Phe Pro Pro
         115                 120                 125

 cag gag att tct ctg gag gtc aga gaa aca gaa gcc aag gtt ata aaa      432
 Gln Glu Ile Ser Leu Glu Val Arg Glu Thr Glu Ala Lys Val Ile Lys
     130                 135                 140

 gct ttc ctt tca gcc cac tgg aca gtc tgt tcc ccc gtg gac tct ctg      480
 Ala Phe Leu Ser Ala His Trp Thr Val Cys Ser Pro Val Asp Ser Leu
 145                 150                 155                 160

 tcc tcc ttt cag ctt agc aaa cat ctc gaa agc tgt ttt gat ctt gtt      528
 Ser Ser Phe Gln Leu Ser Lys His Leu Glu Ser Cys Phe Asp Leu Val
                 165                 170                 175

 tct tgg ttt ctg tgt gtt gtc tcc cag gag cac atg cag aca cac cag      576
 Ser Trp Phe Leu Cys Val Val Ser Gln Glu His Met Gln Thr His Gln
             180                 185                 190

 gcc ggc ccc tct ttg agc tcc cag aag cca aga gtg ttt aaa tgt gac      624
 Ala Gly Pro Ser Leu Ser Ser Gln Lys Pro Arg Val Phe Lys Cys Asp
         195                 200                 205

 act tgt gag aag gca ttt gcc aaa cca agc cag ctg gag cgc cac agc      672
 Thr Cys Glu Lys Ala Phe Ala Lys Pro Ser Gln Leu Glu Arg His Ser
     210                 215                 220

 cgc ata cat aca ggg gag cgg ccg ttc cat tgc acg ctt tgt gag aaa      720
 Arg Ile His Thr Gly Glu Arg Pro Phe His Cys Thr Leu Cys Glu Lys
 225                 230                 235                 240

 gcc ttc aac cag aag agt gcg ctg cag gtg cac atg aag aag cac acg      768
 Ala Phe Asn Gln Lys Ser Ala Leu Gln Val His Met Lys Lys His Thr
                 245                 250                 255

 ggg gag cgg ccc tac aag tgt gcc tac tgc gtc atg ggc ttc acg cag      816
 Gly Glu Arg Pro Tyr Lys Cys Ala Tyr Cys Val Met Gly Phe Thr Gln
             260                 265                 270

 aag agc aac atg aag ctg cac atg aag cgg gcg cac agc tat gct gca      864
 Lys Ser Asn Met Lys Leu His Met Lys Arg Ala His Ser Tyr Ala Ala
         275                 280                 285

 tgc agt tca ggt gct gtc tcg gtg ctc agg ggc aca gag caa aca gaa      912
 Cys Ser Ser Gly Ala Val Ser Val Leu Arg Gly Thr Glu Gln Thr Glu
     290                 295                 300

 tct gca cca act gct cct gtc tgc atc ctg ttg acc tgg cac aga caa      960
 Ser Ala Pro Thr Ala Pro Val Cys Ile Leu Leu Thr Trp His Arg Gln
 305                 310                 315                 320

 cac gtg ggc ctt ggt ttc tct ctt gat tcg cta acg ttc atg ccc ttc     1008
 His Val Gly Leu Gly Phe Ser Leu Asp Ser Leu Thr Phe Met Pro Phe
                 325                 330                 335

 aga gtc cag ggt tac ata att gca gaa gca caa gcc ata cat cgc agg     1056
 Arg Val Gln Gly Tyr Ile Ile Ala Glu Ala Gln Ala Ile His Arg Arg
             340                 345                 350

 agg cat att gct ctg ata gat ttt gaa ata gag tgg gtg agg gaa gcg     1104
 Arg His Ile Ala Leu Ile Asp Phe Glu Ile Glu Trp Val Arg Glu Ala
         355                 360                 365

 ctt tgg atc cca cta cga tgg atc atc tca act att ggc agt gct ttt     1152
 Leu Trp Ile Pro Leu Arg Trp Ile Ile Ser Thr Ile Gly Ser Ala Phe
     370                 375                 380

 cca gct gtg tgc ctc cat ggc agt gac cag caa aag cgc aag ggt gcc     1200
 Pro Ala Val Cys Leu His Gly Ser Asp Gln Gln Lys Arg Lys Gly Ala
 385                 390                 395                 400

 gca gcc acg gcg aaa aga aag tcc aag ggt gga ggg gtg aac gtg gag     1248
 Ala Ala Thr Ala Lys Arg Lys Ser Lys Gly Gly Gly Val Asn Val Glu
                 405                 410                 415

 gga cgt ctg tgc acc tgg ccc cct gaa gac cca ccc aaa tcc tgg tct     1296
 Gly Arg Leu Cys Thr Trp Pro Pro Glu Asp Pro Pro Lys Ser Trp Ser
             420                 425                 430

 ctg gcc ttc ggc ccc ctg caa gag aag acc acg gag ctc aac ctc cac     1344
 Leu Ala Phe Gly Pro Leu Gln Glu Lys Thr Thr Glu Leu Asn Leu His
         435                 440                 445

 ccg cgg tgc tgg gca cgc tgc ttg agc cac tgg gag ctg cca cca ggg     1392
 Pro Arg Cys Trp Ala Arg Cys Leu Ser His Trp Glu Leu Pro Pro Gly
     450                 455                 460

 ccc cgg gga agg gcc cag gcc ccg gac tgg act ggt tgc aaa gcc tgt     1440
 Pro Arg Gly Arg Ala Gln Ala Pro Asp Trp Thr Gly Cys Lys Ala Cys
 465                 470                 475                 480

 gtt ttt agg cta agc gtt aca tgg gag cct aat ctc aag aga agt gag     1488
 Val Phe Arg Leu Ser Val Thr Trp Glu Pro Asn Leu Lys Arg Ser Glu
                 485                 490                 495

 ctc tct gga gaa cgc acg gag cgc acg gtg caa tcc gtg gca gat aca     1536
 Leu Ser Gly Glu Arg Thr Glu Arg Thr Val Gln Ser Val Ala Asp Thr
             500                 505                 510

 gtc ggg aag cgc ttg cct gga act cgc gat cag aag aca gtt ttg cca     1584
 Val Gly Lys Arg Leu Pro Gly Thr Arg Asp Gln Lys Thr Val Leu Pro
         515                 520                 525

 cca aag gcc taa                                                     1596
 Pro Lys Ala 
     530





      <210> 798
      <211> 609
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (1)..(609)

      <400> 798
  atg gct cca ctc cgc gcg ctg ctg tcc tac ctg ctg cct ttg cac tgt      48
  Met Ala Pro Leu Arg Ala Leu Leu Ser Tyr Leu Leu Pro Leu His Cys
    1               5                  10                  15

 gcg ctc tgc gcc gcc gcg ggc agc cgg acc cca gag ctg cac ctc tct       96
 Ala Leu Cys Ala Ala Ala Gly Ser Arg Thr Pro Glu Leu His Leu Ser
              20                  25                  30

 gga aag ctc agt gac tat ggt gtg aca gtg ccc tgc agc aca gac ttt      144
 Gly Lys Leu Ser Asp Tyr Gly Val Thr Val Pro Cys Ser Thr Asp Phe
          35                  40                  45

 cgg gga cgc ttc ctc tcc cac gtg gtg tct ggc cca gca gca gcc tct      192
 Arg Gly Arg Phe Leu Ser His Val Val Ser Gly Pro Ala Ala Ala Ser
      50                  55                  60

 gca ggg agc atg gta gtg gac acg cca ccc aca cta cca cga cac tcc      240
 Ala Gly Ser Met Val Val Asp Thr Pro Pro Thr Leu Pro Arg His Ser
  65                  70                  75                  80

 agt cac ctc cgg gtg gct cgc agc cct ctg cac cca gga ggg acc ctg      288
 Ser His Leu Arg Val Ala Arg Ser Pro Leu His Pro Gly Gly Thr Leu
                  85                  90                  95

 tgg cct ggc agg gtg ggg cgc cac tcc ctc tac ttc aat gtc act gtt      336
 Trp Pro Gly Arg Val Gly Arg His Ser Leu Tyr Phe Asn Val Thr Val
             100                 105                 110

 ttc ggg aag gaa ctg cac ttg cgc ctg cgg ccc aat cgg agg ttg gta      384
 Phe Gly Lys Glu Leu His Leu Arg Leu Arg Pro Asn Arg Arg Leu Val
         115                 120                 125

 gtg cca gga tcc tca gtg gag tgg cag gag gat ttt cgg gag ctg ttc      432
 Val Pro Gly Ser Ser Val Glu Trp Gln Glu Asp Phe Arg Glu Leu Phe
     130                 135                 140

 cgg cag ccc tta cgg cag gag tgt gtg tac act gga ggt gtc act gga      480
 Arg Gln Pro Leu Arg Gln Glu Cys Val Tyr Thr Gly Gly Val Thr Gly
 145                 150                 155                 160

 atg cct ggg gca gct gtt gcc atc agc aac tgt gac gga ttg tgt gca      528
 Met Pro Gly Ala Ala Val Ala Ile Ser Asn Cys Asp Gly Leu Cys Ala
                 165                 170                 175

 ggc cct tgt gag ctg gca cag cag cct caa ggt cct gtt ggg cag ctc      576
 Gly Pro Cys Glu Leu Ala Gln Gln Pro Gln Gly Pro Val Gly Gln Leu
             180                 185                 190

 ttc cct gcc cca gag aca tca gat gtg agc tga                          609
 Phe Pro Ala Pro Glu Thr Ser Asp Val Ser 
         195                 200





      <210> 799
      <211> 8937
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (1)..(8937)

      <400> 799
  atg aac att agt gtc acc cta tta gct aca gtg ctg gct gca ggt ttt      48
  Met Asn Ile Ser Val Thr Leu Leu Ala Thr Val Leu Ala Ala Gly Phe
    1               5                  10                  15

 tct caa gca aac cag ttt aac tat gga gtt gat aac gct gag ttg gga       96
 Ser Gln Ala Asn Gln Phe Asn Tyr Gly Val Asp Asn Ala Glu Leu Gly
              20                  25                  30

 aac agt gtg caa tta att tct tct ttc cag tca att act tgt gat gta      144
 Asn Ser Val Gln Leu Ile Ser Ser Phe Gln Ser Ile Thr Cys Asp Val
          35                  40                  45

 gaa aaa gat gca agt cat tca act caa att aca tgc tat act aga gca      192
 Glu Lys Asp Ala Ser His Ser Thr Gln Ile Thr Cys Tyr Thr Arg Ala
      50                  55                  60

 atg ccg gaa gat tcc tac act gtt aga gtc agt gtg gac ggg gtt cct      240
 Met Pro Glu Asp Ser Tyr Thr Val Arg Val Ser Val Asp Gly Val Pro
  65                  70                  75                  80

 gtt acg gaa aat aac acc tgc aaa ggt cac atc aac agc tgg gaa tgt      288
 Val Thr Glu Asn Asn Thr Cys Lys Gly His Ile Asn Ser Trp Glu Cys
                  85                  90                  95

 acc ttc aac gca aaa agt ttt aga acc cca aca ata aga agc atc aca      336
 Thr Phe Asn Ala Lys Ser Phe Arg Thr Pro Thr Ile Arg Ser Ile Thr
             100                 105                 110

 cct tta tct gga act cca ggt gaa cct tgt gat att ttg aat gtc aca      384
 Pro Leu Ser Gly Thr Pro Gly Glu Pro Cys Asp Ile Leu Asn Val Thr
         115                 120                 125

 gaa aat agt ata tgt tgc aag aca ccc ccc aaa cct cat att ctc aaa      432
 Glu Asn Ser Ile Cys Cys Lys Thr Pro Pro Lys Pro His Ile Leu Lys
     130                 135                 140

 act gta tat cca gga ggg aga ggc ctg aag ctt gag gtg tgg aat aat      480
 Thr Val Tyr Pro Gly Gly Arg Gly Leu Lys Leu Glu Val Trp Asn Asn
 145                 150                 155                 160

 agc cgt cca ata cgt ttg gaa gag ata ctg gaa tac aat gaa aaa acg      528
 Ser Arg Pro Ile Arg Leu Glu Glu Ile Leu Glu Tyr Asn Glu Lys Thr
                 165                 170                 175

 cct ggg tac atg ggt gcc agt tgg gta gat tca gct tcc tat att tgg      576
 Pro Gly Tyr Met Gly Ala Ser Trp Val Asp Ser Ala Ser Tyr Ile Trp
             180                 185                 190

 ctc atg gaa caa gac aca ttt gtt gca cgc ttt agt gga ttt ttg gtg      624
 Leu Met Glu Gln Asp Thr Phe Val Ala Arg Phe Ser Gly Phe Leu Val
         195                 200                 205

 gct cca gat tct gat gtt tat aga ttc tac atc aag ggt gat gac cgt      672
 Ala Pro Asp Ser Asp Val Tyr Arg Phe Tyr Ile Lys Gly Asp Asp Arg
     210                 215                 220

 tat gct att tat ttt agc cag act gga ctt cca gaa gat aag gtg agg      720
 Tyr Ala Ile Tyr Phe Ser Gln Thr Gly Leu Pro Glu Asp Lys Val Arg
 225                 230                 235                 240

 att gca tat cat tct gct aat gcc aac agt tat ttt tcc agt cca aca      768
 Ile Ala Tyr His Ser Ala Asn Ala Asn Ser Tyr Phe Ser Ser Pro Thr
                 245                 250                 255

 caa aga tca gat gat att cat ctg cag aaa gga aaa gaa tac tat att      816
 Gln Arg Ser Asp Asp Ile His Leu Gln Lys Gly Lys Glu Tyr Tyr Ile
             260                 265                 270

 gaa atc ttg ctg cag gag tac aga tta agt gca ttt gtt gat gtt gga      864
 Glu Ile Leu Leu Gln Glu Tyr Arg Leu Ser Ala Phe Val Asp Val Gly
         275                 280                 285

 ctg tac cag tat cga aat gtt tat act gaa caa caa aca gga gat gca      912
 Leu Tyr Gln Tyr Arg Asn Val Tyr Thr Glu Gln Gln Thr Gly Asp Ala
     290                 295                 300

 gtg aat gaa gaa caa gtt atc aaa tcc cag tcg aca atc ctc cag gaa      960
 Val Asn Glu Glu Gln Val Ile Lys Ser Gln Ser Thr Ile Leu Gln Glu
 305                 310                 315                 320

 gta cag gtt ata aca ttg gaa aac tgg gaa aca act aat gca att aat     1008
 Val Gln Val Ile Thr Leu Glu Asn Trp Glu Thr Thr Asn Ala Ile Asn
                 325                 330                 335

 gag gtt cag aag atc aag gta acc agc cca tgt gtg gaa gct aat tca     1056
 Glu Val Gln Lys Ile Lys Val Thr Ser Pro Cys Val Glu Ala Asn Ser
             340                 345                 350

 tgt tca ctt tac caa tat aga tta atc tat aat atg gaa aaa act gga     1104
 Cys Ser Leu Tyr Gln Tyr Arg Leu Ile Tyr Asn Met Glu Lys Thr Gly
         355                 360                 365

 gac ttt gat ctg ctt ggt tat gaa gta gtt gaa ggg aat aat gtc aca     1152
 Asp Phe Asp Leu Leu Gly Tyr Glu Val Val Glu Gly Asn Asn Val Thr
     370                 375                 380

 ctg gat att aca gaa caa acc aaa gga aaa ccc aac ttg gag aca ttc     1200
 Leu Asp Ile Thr Glu Gln Thr Lys Gly Lys Pro Asn Leu Glu Thr Phe
 385                 390                 395                 400

 aca ctg aat tgg gat ggg atc gct tct aag cca ctc act cta tgg tca     1248
 Thr Leu Asn Trp Asp Gly Ile Ala Ser Lys Pro Leu Thr Leu Trp Ser
                 405                 410                 415

 tca gaa gct gaa gga gca gtg gaa gaa atg gtt agc act aag tgt cca     1296
 Ser Glu Ala Glu Gly Ala Val Glu Glu Met Val Ser Thr Lys Cys Pro
             420                 425                 430

 cca caa att gca aat ttt gaa gaa gga ttt gtt gtg aaa tat ttc aga     1344
 Pro Gln Ile Ala Asn Phe Glu Glu Gly Phe Val Val Lys Tyr Phe Arg
         435                 440                 445

 gac tat gaa act gat ttt aat ctg gaa cat att aac aga ggg cag aag     1392
 Asp Tyr Glu Thr Asp Phe Asn Leu Glu His Ile Asn Arg Gly Gln Lys
     450                 455                 460

 aca gct gaa acc gat gct tac tgt ggt cgt tat tcc ctg aaa aac cca     1440
 Thr Ala Glu Thr Asp Ala Tyr Cys Gly Arg Tyr Ser Leu Lys Asn Pro
 465                 470                 475                 480

 gct gtt ctt ttt gac tca gca gat gtt aaa cca aac aga cga cca tat     1488
 Ala Val Leu Phe Asp Ser Ala Asp Val Lys Pro Asn Arg Arg Pro Tyr
                 485                 490                 495

 gga gat att tta ttg ttt cct tat aat cag agg att agc tta cat aaa     1536
 Gly Asp Ile Leu Leu Phe Pro Tyr Asn Gln Arg Ile Ser Leu His Lys
             500                 505                 510

 gca tca gaa tca cag tcc ttc tat gtg gat gta gtg tac att gga cac     1584
 Ala Ser Glu Ser Gln Ser Phe Tyr Val Asp Val Val Tyr Ile Gly His
         515                 520                 525

 aca tct aca atc tca aca ttg gat gaa atg ccc aag aga aga ctt cct     1632
 Thr Ser Thr Ile Ser Thr Leu Asp Glu Met Pro Lys Arg Arg Leu Pro
     530                 535                 540

 gca tta gca aat aaa gga ata ttc tta gag cac ttt cag gtg aat cag     1680
 Ala Leu Ala Asn Lys Gly Ile Phe Leu Glu His Phe Gln Val Asn Gln
 545                 550                 555                 560

 acc aaa aca aat ggg cca act atg aca aac caa tat tct gtt acc atg     1728
 Thr Lys Thr Asn Gly Pro Thr Met Thr Asn Gln Tyr Ser Val Thr Met
                 565                 570                 575

 act tca tac aat tgc agt tac aat ata ccc atg atg gct gtg agc ttt     1776
 Thr Ser Tyr Asn Cys Ser Tyr Asn Ile Pro Met Met Ala Val Ser Phe
             580                 585                 590

 ggg cag gtt gaa gtc tat gtc aat gga att cca gct aaa tgt tca ggt     1824
 Gly Gln Val Glu Val Tyr Val Asn Gly Ile Pro Ala Lys Cys Ser Gly
         595                 600                 605

 gac tgt gga ttt aca tgg gat tcc aac att act ccc cta gtc ttg gcg     1872
 Asp Cys Gly Phe Thr Trp Asp Ser Asn Ile Thr Pro Leu Val Leu Ala
     610                 615                 620

 ata agc cct tct caa ggg tcc tat gaa gaa ggc aca att cta acc ata     1920
 Ile Ser Pro Ser Gln Gly Ser Tyr Glu Glu Gly Thr Ile Leu Thr Ile
 625                 630                 635                 640

 gtg ggt tct gga ttt tct cct agt tca gct gta aca gtc tca gtt gga     1968
 Val Gly Ser Gly Phe Ser Pro Ser Ser Ala Val Thr Val Ser Val Gly
                 645                 650                 655

 cca gta ggt tgt tct ctt ctt tct gtg gat gaa aaa gag ctc aag tgc     2016
 Pro Val Gly Cys Ser Leu Leu Ser Val Asp Glu Lys Glu Leu Lys Cys
             660                 665                 670

 cag att ctg aat gga agt gct gga cat gcc ccc gtt gct gtg tcc atg     2064
 Gln Ile Leu Asn Gly Ser Ala Gly His Ala Pro Val Ala Val Ser Met
         675                 680                 685

 gct gat gtt gga cta gca cag aat gta ggg ggt gaa gag ttc tac ttt     2112
 Ala Asp Val Gly Leu Ala Gln Asn Val Gly Gly Glu Glu Phe Tyr Phe
     690                 695                 700

 gtt tat cag agt cag atc tca cat atc tgg cct gat tct gga agc ata     2160
 Val Tyr Gln Ser Gln Ile Ser His Ile Trp Pro Asp Ser Gly Ser Ile
 705                 710                 715                 720

 gca ggt ggt act cta ctg act tta tct gga ttt ggc ttt aat gaa aat     2208
 Ala Gly Gly Thr Leu Leu Thr Leu Ser Gly Phe Gly Phe Asn Glu Asn
                 725                 730                 735

 tca aag gta tta gtt gga aat gaa acc tgc aat gtg att gaa ggg gat     2256
 Ser Lys Val Leu Val Gly Asn Glu Thr Cys Asn Val Ile Glu Gly Asp
             740                 745                 750

 ttg aat agg ata acc tgc agg aca cca aaa aaa act gag ggt aca gtt     2304
 Leu Asn Arg Ile Thr Cys Arg Thr Pro Lys Lys Thr Glu Gly Thr Val
         755                 760                 765

 gat att tca gtt act acc aat gga ttt caa gcc aca gca agg gat gct     2352
 Asp Ile Ser Val Thr Thr Asn Gly Phe Gln Ala Thr Ala Arg Asp Ala
     770                 775                 780

 ttt agt tat aat tgt tta cag aca cca att ata act gat ttt agt cca     2400
 Phe Ser Tyr Asn Cys Leu Gln Thr Pro Ile Ile Thr Asp Phe Ser Pro
 785                 790                 795                 800

 aaa gta cga aca ata cta gga gaa gtt aat tta aca att aag ggc tat     2448
 Lys Val Arg Thr Ile Leu Gly Glu Val Asn Leu Thr Ile Lys Gly Tyr
                 805                 810                 815

 aat ttt gga aat gaa ctc aca caa aac atg gcg gtg tat gtt gga gga     2496
 Asn Phe Gly Asn Glu Leu Thr Gln Asn Met Ala Val Tyr Val Gly Gly
             820                 825                 830

 aaa acc tgc cag att ctt cac tgg aac ttc aca gat att aga tgc ctt     2544
 Lys Thr Cys Gln Ile Leu His Trp Asn Phe Thr Asp Ile Arg Cys Leu
         835                 840                 845

 ttg ccc aag ttg tct cct gga aaa cat gat atc tat gta gaa gtc aga     2592
 Leu Pro Lys Leu Ser Pro Gly Lys His Asp Ile Tyr Val Glu Val Arg
     850                 855                 860

 aac tgg ggt ttt gca tca aca aga gac aaa tta aat tct tca ata cag     2640
 Asn Trp Gly Phe Ala Ser Thr Arg Asp Lys Leu Asn Ser Ser Ile Gln
 865                 870                 875                 880

 tat gtt tta gaa gtg acc agc atg ttt cca caa aga ggc tcc ttg ttt     2688
 Tyr Val Leu Glu Val Thr Ser Met Phe Pro Gln Arg Gly Ser Leu Phe
                 885                 890                 895

 ggt gga act gaa atc acc ata agg ggt ttt gga ttc agc aca ata cca     2736
 Gly Gly Thr Glu Ile Thr Ile Arg Gly Phe Gly Phe Ser Thr Ile Pro
             900                 905                 910

 gct gag aat acc gtg ctg tta gta cat gga tta ggt tat gcc tgg tca     2784
 Ala Glu Asn Thr Val Leu Leu Val His Gly Leu Gly Tyr Ala Trp Ser
         915                 920                 925

 cca cca gtc cta aat gtg tct gtg ggg gac aca gtg gca tgg cat tgg     2832
 Pro Pro Val Leu Asn Val Ser Val Gly Asp Thr Val Ala Trp His Trp
     930                 935                 940

 caa aca cat ccg ttt ctt aga ggg ata gga tat agg att ttt tct gtc     2880
 Gln Thr His Pro Phe Leu Arg Gly Ile Gly Tyr Arg Ile Phe Ser Val
 945                 950                 955                 960

 tcc agt cct gga agt gta att tat gat ggc aaa gga ttc aca agt gga     2928
 Ser Ser Pro Gly Ser Val Ile Tyr Asp Gly Lys Gly Phe Thr Ser Gly
                 965                 970                 975

 aga caa aaa tct aca tca gga gtc att aat gtt tta cca gct gaa acc     2976
 Arg Gln Lys Ser Thr Ser Gly Val Ile Asn Val Leu Pro Ala Glu Thr
             980                 985                 990

 aga cac att ccc ttg cac ctg ttt gtg ggt cgc tct gaa gcc aca tat     3024
 Arg His Ile Pro Leu His Leu Phe Val Gly Arg Ser Glu Ala Thr Tyr
         995                1000                1005

 gct tat ggt aag atg gtt aaa gat gga aac tct gtt aca cag gtt aca     3072
 Ala Tyr Gly Lys Met Val Lys Asp Gly Asn Ser Val Thr Gln Val Thr
    1010                1015                1020

 att ggt agc tac ccc tgt gtc gta gaa gaa agt agt gag gat tca att     3120
 Ile Gly Ser Tyr Pro Cys Val Val Glu Glu Ser Ser Glu Asp Ser Ile
1025                1030                1035                1040

 aca tgt cat att gac cct caa aac tca atg gat gtt ggt atc agg gaa     3168
 Thr Cys His Ile Asp Pro Gln Asn Ser Met Asp Val Gly Ile Arg Glu
                1045                1050                1055

 act gtc act ttg act gtc tac aac ctg ggc act gct atc aat acg ttg     3216
 Thr Val Thr Leu Thr Val Tyr Asn Leu Gly Thr Ala Ile Asn Thr Leu
            1060                1065                1070

 tcc aat gaa ttt gat agg cga ttt gta ctt ttg cca aac att gac ctg     3264
 Ser Asn Glu Phe Asp Arg Arg Phe Val Leu Leu Pro Asn Ile Asp Leu
        1075                1080                1085

 gtg ttg cca aat gca gga tca act aca gga atg aca agc gtg acc ata     3312
 Val Leu Pro Asn Ala Gly Ser Thr Thr Gly Met Thr Ser Val Thr Ile
    1090                1095                1100

 aaa ggc tct gga ttt gcc gtt tct tct gca ggt gta aaa gtc ctt atg     3360
 Lys Gly Ser Gly Phe Ala Val Ser Ser Ala Gly Val Lys Val Leu Met
1105                1110                1115                1120

 ggt cat ttc cca tgt aaa gtt cta tca gtg aat tat acg gcc att gaa     3408
 Gly His Phe Pro Cys Lys Val Leu Ser Val Asn Tyr Thr Ala Ile Glu
                1125                1130                1135

 tgt gaa aca tcc cct gct gcc caa cag ctt gtg gat gta gat ctt cta     3456
 Cys Glu Thr Ser Pro Ala Ala Gln Gln Leu Val Asp Val Asp Leu Leu
            1140                1145                1150

 ata cat gga gtg cct gcc cag tgc cag gga aac tgc acc ttt tca tac     3504
 Ile His Gly Val Pro Ala Gln Cys Gln Gly Asn Cys Thr Phe Ser Tyr
        1155                1160                1165

 tta gaa agc atc act cct tac ata aca gga gtc ttc cca aac tct gtc     3552
 Leu Glu Ser Ile Thr Pro Tyr Ile Thr Gly Val Phe Pro Asn Ser Val
    1170                1175                1180

 ata gga tct gta aaa gtt ctt att gaa gga gaa ggt ttg ggg act gtt     3600
 Ile Gly Ser Val Lys Val Leu Ile Glu Gly Glu Gly Leu Gly Thr Val
1185                1190                1195                1200

 ttg gag gac att gct gtt ttc att gga aat caa cag ttc aga gca ata     3648
 Leu Glu Asp Ile Ala Val Phe Ile Gly Asn Gln Gln Phe Arg Ala Ile
                1205                1210                1215

 gag gtt aat gaa aac aac atc act gct ctt gtg act cct ctc cca gtt     3696
 Glu Val Asn Glu Asn Asn Ile Thr Ala Leu Val Thr Pro Leu Pro Val
            1220                1225                1230

 gga cat cat tct gtt agt gtt gtg gtg gga agt aaa ggc ttg gct ctg     3744
 Gly His His Ser Val Ser Val Val Val Gly Ser Lys Gly Leu Ala Leu
        1235                1240                1245

 gga aac ctg act gtc agc agc ccc cca gta gca tct cta tca cca act     3792
 Gly Asn Leu Thr Val Ser Ser Pro Pro Val Ala Ser Leu Ser Pro Thr
    1250                1255                1260

 tct gga agc att ggt ggt gga act aca ctg gtg atc aca gga aat ggc     3840
 Ser Gly Ser Ile Gly Gly Gly Thr Thr Leu Val Ile Thr Gly Asn Gly
1265                1270                1275                1280

 ttc tat cca ggc aac act aca gtc act att ggg gat gaa cct tgt caa     3888
 Phe Tyr Pro Gly Asn Thr Thr Val Thr Ile Gly Asp Glu Pro Cys Gln
                1285                1290                1295

 att att tcc atc aac ccc aat gaa gtc tac tgc cgc act ccc gct ggg     3936
 Ile Ile Ser Ile Asn Pro Asn Glu Val Tyr Cys Arg Thr Pro Ala Gly
            1300                1305                1310

 acc act gga atg gtc gat gtt aaa atc ttt gtt aat aca att gct tat     3984
 Thr Thr Gly Met Val Asp Val Lys Ile Phe Val Asn Thr Ile Ala Tyr
        1315                1320                1325

 cca cct ttg ctt ttt aca tat gcc ctg gag gat act cca ttt ctc aga     4032
 Pro Pro Leu Leu Phe Thr Tyr Ala Leu Glu Asp Thr Pro Phe Leu Arg
    1330                1335                1340

 gga att atc cca agc aga ggt cca cca gga act gaa att gag atc act     4080
 Gly Ile Ile Pro Ser Arg Gly Pro Pro Gly Thr Glu Ile Glu Ile Thr
1345                1350                1355                1360

 gga tcc aac ttt ggc ttt gag atc ttg gaa atc tcc gtg atg ata aat     4128
 Gly Ser Asn Phe Gly Phe Glu Ile Leu Glu Ile Ser Val Met Ile Asn
                1365                1370                1375

 aac att cag tgt aat gta acc atg gcc aat gat agt gtg gtg cag tgc     4176
 Asn Ile Gln Cys Asn Val Thr Met Ala Asn Asp Ser Val Val Gln Cys
            1380                1385                1390

 atc gtg gga gat cat gct ggg ggc aca ttt cct gtt atg atg cat cat     4224
 Ile Val Gly Asp His Ala Gly Gly Thr Phe Pro Val Met Met His His
        1395                1400                1405

 aag aca aaa ggc tca gcc atg tcc aca gtt gta ttt gag tac ccg ctt     4272
 Lys Thr Lys Gly Ser Ala Met Ser Thr Val Val Phe Glu Tyr Pro Leu
    1410                1415                1420

 aat att caa aat att aat cca agc caa ggg agc ttt ggt ggg ggt caa     4320
 Asn Ile Gln Asn Ile Asn Pro Ser Gln Gly Ser Phe Gly Gly Gly Gln
1425                1430                1435                1440

 acc atg act gtg aca ggc acc gga ttt aat cca caa aat tca att ata     4368
 Thr Met Thr Val Thr Gly Thr Gly Phe Asn Pro Gln Asn Ser Ile Ile
                1445                1450                1455

 tta gtt tgt ggc tca gaa tgt gca att gac agg ctt aga tct gat tac     4416
 Leu Val Cys Gly Ser Glu Cys Ala Ile Asp Arg Leu Arg Ser Asp Tyr
            1460                1465                1470

 aca aca cta tta tgt gaa att cca tct aat aat ggc acg gga gct gag     4464
 Thr Thr Leu Leu Cys Glu Ile Pro Ser Asn Asn Gly Thr Gly Ala Glu
        1475                1480                1485

 caa gcc tgt gaa gtg agt gtg gtt aat ggg aaa gat ttg tca cag tcc     4512
 Gln Ala Cys Glu Val Ser Val Val Asn Gly Lys Asp Leu Ser Gln Ser
    1490                1495                1500

 atg act ccg ttt acg tac gca gtg tca ctg act cca ctc atc act gca     4560
 Met Thr Pro Phe Thr Tyr Ala Val Ser Leu Thr Pro Leu Ile Thr Ala
1505                1510                1515                1520

 gta tct cct aag aga ggc agt aca gca ggg ggc acc aga ctg aca gtc     4608
 Val Ser Pro Lys Arg Gly Ser Thr Ala Gly Gly Thr Arg Leu Thr Val
                1525                1530                1535

 gtg gga tca gga ttc agt gaa aat atg gag gat gtt cat atc acc ata     4656
 Val Gly Ser Gly Phe Ser Glu Asn Met Glu Asp Val His Ile Thr Ile
            1540                1545                1550

 gct gaa gcc aaa tgt gat gtt gag tat tcc aac aag aca cac atc atc     4704
 Ala Glu Ala Lys Cys Asp Val Glu Tyr Ser Asn Lys Thr His Ile Ile
        1555                1560                1565

 tgc atg aca gat gcc cat act cta tca ggg tgg gct cca gtt tgt gtc     4752
 Cys Met Thr Asp Ala His Thr Leu Ser Gly Trp Ala Pro Val Cys Val
    1570                1575                1580

 cac atc aga ggt gtc ggc atg gcc aaa ctg gat aat gct gac ttt ctt     4800
 His Ile Arg Gly Val Gly Met Ala Lys Leu Asp Asn Ala Asp Phe Leu
1585                1590                1595                1600

 tat gtt gat gcc tgg tcc tcc aat ttc tca tgg ggg gga aaa tct ccc     4848
 Tyr Val Asp Ala Trp Ser Ser Asn Phe Ser Trp Gly Gly Lys Ser Pro
                1605                1610                1615

 cca gaa gaa gga tct ctt gtt gtt att aca aaa gga cag acc att ctg     4896
 Pro Glu Glu Gly Ser Leu Val Val Ile Thr Lys Gly Gln Thr Ile Leu
            1620                1625                1630

 ctg gat caa agc acc cct att ttg aaa atg ttg ctt att cag ggt gtg     4944
 Leu Asp Gln Ser Thr Pro Ile Leu Lys Met Leu Leu Ile Gln Gly Val
        1635                1640                1645

 cct gtt cct gtg acc tgg act cgc ttg gct cat act gca aag gca ggg     4992
 Pro Val Pro Val Thr Trp Thr Arg Leu Ala His Thr Ala Lys Ala Gly
    1650                1655                1660

 gaa aga att tta att tta caa gaa gca gta aca tgg aaa cca gga gat     5040
 Glu Arg Ile Leu Ile Leu Gln Glu Ala Val Thr Trp Lys Pro Gly Asp
1665                1670                1675                1680

 aac att gta att gca agc aca gga cac aga cac agt caa gga gag aat     5088
 Asn Ile Val Ile Ala Ser Thr Gly His Arg His Ser Gln Gly Glu Asn
                1685                1690                1695

 gaa aaa atg acc att gca tct gtg tct gct gat ggc ata aac ata aca     5136
 Glu Lys Met Thr Ile Ala Ser Val Ser Ala Asp Gly Ile Asn Ile Thr
            1700                1705                1710

 cta agt aac cca cta aat tac aca cac tta gga att acg gtc aca ctc     5184
 Leu Ser Asn Pro Leu Asn Tyr Thr His Leu Gly Ile Thr Val Thr Leu
        1715                1720                1725

 cct gat gga act ctg ttt gaa gca aga gca gaa gtt gga att ctt aca     5232
 Pro Asp Gly Thr Leu Phe Glu Ala Arg Ala Glu Val Gly Ile Leu Thr
    1730                1735                1740

 aga aat att tta ata aga gga tct gat aat gtt gag tgg aat aac aaa     5280
 Arg Asn Ile Leu Ile Arg Gly Ser Asp Asn Val Glu Trp Asn Asn Lys
1745                1750                1755                1760

 att cct gca tgt cct gat gga ttt gac aca gga gaa ttt gct aca cag     5328
 Ile Pro Ala Cys Pro Asp Gly Phe Asp Thr Gly Glu Phe Ala Thr Gln
                1765                1770                1775

 acc tgt ctc caa gga aag ttt gga gaa gaa ata gga agt gac caa ttt     5376
 Thr Cys Leu Gln Gly Lys Phe Gly Glu Glu Ile Gly Ser Asp Gln Phe
            1780                1785                1790

 gga ggc tgc gtt atg ttt cat gct cct gta cct ggt gct aac atg gta     5424
 Gly Gly Cys Val Met Phe His Ala Pro Val Pro Gly Ala Asn Met Val
        1795                1800                1805

 act ggg aga ata gaa tat gta gag gta ttc cat gct ggc cag gct ttc     5472
 Thr Gly Arg Ile Glu Tyr Val Glu Val Phe His Ala Gly Gln Ala Phe
    1810                1815                1820

 cgg ttg ggg cga tat cca ata cat tgg cac ctg ctt gga gac tta cag     5520
 Arg Leu Gly Arg Tyr Pro Ile His Trp His Leu Leu Gly Asp Leu Gln
1825                1830                1835                1840

 ttt aaa tct tat gta aga ggc tgt gca att cac cag gcc tat aac aga     5568
 Phe Lys Ser Tyr Val Arg Gly Cys Ala Ile His Gln Ala Tyr Asn Arg
                1845                1850                1855

 gct gtt act att cat aac aca cac cat ctt ctg gtt gag agg aat att     5616
 Ala Val Thr Ile His Asn Thr His His Leu Leu Val Glu Arg Asn Ile
            1860                1865                1870

 ata tat gat att aag gga gga gca ttt ttt ata gaa gat ggt att gaa     5664
 Ile Tyr Asp Ile Lys Gly Gly Ala Phe Phe Ile Glu Asp Gly Ile Glu
        1875                1880                1885

 cat ggc aat atc ctc cag tat aac ttg gca gta ttt gta cag caa agt     5712
 His Gly Asn Ile Leu Gln Tyr Asn Leu Ala Val Phe Val Gln Gln Ser
    1890                1895                1900

 acc agt ctt ctg aat gat gat gtg acc ccg gct gca ttt tgg gtc acc     5760
 Thr Ser Leu Leu Asn Asp Asp Val Thr Pro Ala Ala Phe Trp Val Thr
1905                1910                1915                1920

 aac ccg aac aat acc ata cga cac aat gct gtt gct ggt ggc act cac     5808
 Asn Pro Asn Asn Thr Ile Arg His Asn Ala Val Ala Gly Gly Thr His
                1925                1930                1935

 ttt ggc ttt tgg tac cgg atg aac aac cac cct gat ggg cca tcc tat     5856
 Phe Gly Phe Trp Tyr Arg Met Asn Asn His Pro Asp Gly Pro Ser Tyr
            1940                1945                1950

 gac aga aac att tgt caa aaa aga gtt ccc ctt ggc gaa ttt ttt aac     5904
 Asp Arg Asn Ile Cys Gln Lys Arg Val Pro Leu Gly Glu Phe Phe Asn
        1955                1960                1965

 aat act gtc cat tct caa ggt tgg ttt gga atg tgg atc ttt gag gaa     5952
 Asn Thr Val His Ser Gln Gly Trp Phe Gly Met Trp Ile Phe Glu Glu
    1970                1975                1980

 tat ttc ccc atg caa acg gga tct tgt aca tct aca gtg cct gca cct     6000
 Tyr Phe Pro Met Gln Thr Gly Ser Cys Thr Ser Thr Val Pro Ala Pro
1985                1990                1995                2000

 gca ata ttt aac tca ctt act act tgg aat tgt caa aaa gga gct gaa     6048
 Ala Ile Phe Asn Ser Leu Thr Thr Trp Asn Cys Gln Lys Gly Ala Glu
                2005                2010                2015

 tgg gtc aat gga ggt gcc ctt cag ttc cat aac ttt gtg atg gtg aat     6096
 Trp Val Asn Gly Gly Ala Leu Gln Phe His Asn Phe Val Met Val Asn
            2020                2025                2030

 aac tat gag gct gga att gag act aag agg atc ctg gct cct tat gtt     6144
 Asn Tyr Glu Ala Gly Ile Glu Thr Lys Arg Ile Leu Ala Pro Tyr Val
        2035                2040                2045

 gga ggg tgg ggt gaa acc aat gga gcg gtg att aaa aat gcc aaa ata     6192
 Gly Gly Trp Gly Glu Thr Asn Gly Ala Val Ile Lys Asn Ala Lys Ile
    2050                2055                2060

 gtc ggc cat ctt gat gaa ctg gga atg ggg tct gca ttt tgc aca gca     6240
 Val Gly His Leu Asp Glu Leu Gly Met Gly Ser Ala Phe Cys Thr Ala
2065                2070                2075                2080

 aaa ggc ctg gtt ctc cca ttt agt gaa ggc ttg act gtc tct tct gtg     6288
 Lys Gly Leu Val Leu Pro Phe Ser Glu Gly Leu Thr Val Ser Ser Val
                2085                2090                2095

 cac ttt atg aac ttt gac cgt ccc aac tgt gta gct ttg gga gtg aca     6336
 His Phe Met Asn Phe Asp Arg Pro Asn Cys Val Ala Leu Gly Val Thr
            2100                2105                2110

 tcc atc tct gga gtt tgt aat gac aga tgt ggg ggt tgg agt gca aag     6384
 Ser Ile Ser Gly Val Cys Asn Asp Arg Cys Gly Gly Trp Ser Ala Lys
        2115                2120                2125

 ttt gtt gac gtc cag tat tct cac aca ccg aac aag gct ggc ttt cgc     6432
 Phe Val Asp Val Gln Tyr Ser His Thr Pro Asn Lys Ala Gly Phe Arg
    2130                2135                2140

 tgg gaa cat gaa atg gta atg att gat gtt gat ggc tca ctt aca ggg     6480
 Trp Glu His Glu Met Val Met Ile Asp Val Asp Gly Ser Leu Thr Gly
2145                2150                2155                2160

 cac aaa gga cat acc gtc att cca cac agc tca ttg cta gac cct tct     6528
 His Lys Gly His Thr Val Ile Pro His Ser Ser Leu Leu Asp Pro Ser
                2165                2170                2175

 cat tgt act cag gaa gct gag tgg agc att ggg ttc cct gga tca gtc     6576
 His Cys Thr Gln Glu Ala Glu Trp Ser Ile Gly Phe Pro Gly Ser Val
            2180                2185                2190

 tgt gat gct tca gtc agc ttt cac cgt tta gcg ttc aac cag cct tct     6624
 Cys Asp Ala Ser Val Ser Phe His Arg Leu Ala Phe Asn Gln Pro Ser
        2195                2200                2205

 cca gta tct ctg ctt gaa aag gat gtg gtt ctt tca gac tct ttt gtt     6672
 Pro Val Ser Leu Leu Glu Lys Asp Val Val Leu Ser Asp Ser Phe Val
    2210                2215                2220

 gat ccc caa aaa tat ttg gat gaa gat tgg gaa aag tat ctg gag gat     6720
 Asp Pro Gln Lys Tyr Leu Asp Glu Asp Trp Glu Lys Tyr Leu Glu Asp
2225                2230                2235                2240

 cct gct ttt gat acc agt tac tct act gag cct tgt tgg aaa tac tca     6768
 Pro Ala Phe Asp Thr Ser Tyr Ser Thr Glu Pro Cys Trp Lys Tyr Ser
                2245                2250                2255

 gat cat cat gaa aac aaa tac tgt gat ctg gag tgt agc cat act tgt     6816
 Asp His His Glu Asn Lys Tyr Cys Asp Leu Glu Cys Ser His Thr Cys
            2260                2265                2270

 aac tgc aaa acg agg tca tca tca tat tta gat aac tta gtt tgg aga     6864
 Asn Cys Lys Thr Arg Ser Ser Ser Tyr Leu Asp Asn Leu Val Trp Arg
        2275                2280                2285

 gag agt gaa gtt aac cat tac tat gaa ccc aag ctt att ata gat ctt     6912
 Glu Ser Glu Val Asn His Tyr Tyr Glu Pro Lys Leu Ile Ile Asp Leu
    2290                2295                2300

 tcc aat tgg aga gaa caa agc aaa gaa aaa act gat aag aaa ggc aaa     6960
 Ser Asn Trp Arg Glu Gln Ser Lys Glu Lys Thr Asp Lys Lys Gly Lys
2305                2310                2315                2320

 tca aaa tgt gaa agg aat gga ttg gtt aaa gcc cag ata gcg cta gag     7008
 Ser Lys Cys Glu Arg Asn Gly Leu Val Lys Ala Gln Ile Ala Leu Glu
                2325                2330                2335

 gaa gca tca cag caa ctg gct gga aaa gaa agg gaa aag aag cag gga     7056
 Glu Ala Ser Gln Gln Leu Ala Gly Lys Glu Arg Glu Lys Lys Gln Gly
            2340                2345                2350

 ttt gat ttt gat tcc ttt att gca gga act att cag ctt agt tcc cag     7104
 Phe Asp Phe Asp Ser Phe Ile Ala Gly Thr Ile Gln Leu Ser Ser Gln
        2355                2360                2365

 cat gag cct act gat gtt gtt gat aaa tta aat gac ttg aat agc tca     7152
 His Glu Pro Thr Asp Val Val Asp Lys Leu Asn Asp Leu Asn Ser Ser
    2370                2375                2380

 gtg tcc caa cta gaa ttg aaa agt ttg ata tca aat tta tgg tca aat     7200
 Val Ser Gln Leu Glu Leu Lys Ser Leu Ile Ser Asn Leu Trp Ser Asn
2385                2390                2395                2400

 gat tct ttt tgg caa tca tca cga gaa aat aat tat act gta cct cac     7248
 Asp Ser Phe Trp Gln Ser Ser Arg Glu Asn Asn Tyr Thr Val Pro His
                2405                2410                2415

 cca ggg gca aat gtg att ata cct gaa gga aca tgg att gta gct gac     7296
 Pro Gly Ala Asn Val Ile Ile Pro Glu Gly Thr Trp Ile Val Ala Asp
            2420                2425                2430

 ata gat atg cca tca atg gaa aga ctc att att tgg ggg gtt cta gaa     7344
 Ile Asp Met Pro Ser Met Glu Arg Leu Ile Ile Trp Gly Val Leu Glu
        2435                2440                2445

 ctg gaa gat aaa tac aat gta gga gct gca gaa tct tct tac aga gaa     7392
 Leu Glu Asp Lys Tyr Asn Val Gly Ala Ala Glu Ser Ser Tyr Arg Glu
    2450                2455                2460

 gtt gtt ttg aat gct acc tac ata tca ctg cag gga ggt aga tta atc     7440
 Val Val Leu Asn Ala Thr Tyr Ile Ser Leu Gln Gly Gly Arg Leu Ile
2465                2470                2475                2480

 ggt ggc tgg gaa gat aac cct ttt aaa gga gac tta aag att gtt ctt     7488
 Gly Gly Trp Glu Asp Asn Pro Phe Lys Gly Asp Leu Lys Ile Val Leu
                2485                2490                2495

 aga gga aat cat act aca caa gac tgg gct ctt cca gaa gga cca aat     7536
 Arg Gly Asn His Thr Thr Gln Asp Trp Ala Leu Pro Glu Gly Pro Asn
            2500                2505                2510

 caa ggg gca aag gtc tta ggg gtg ttt ggt gag ctg gat ctt cat gga     7584
 Gln Gly Ala Lys Val Leu Gly Val Phe Gly Glu Leu Asp Leu His Gly
        2515                2520                2525

 att cca cat tca ata tat aaa act aag ctc tca gaa act gca ttt gca     7632
 Ile Pro His Ser Ile Tyr Lys Thr Lys Leu Ser Glu Thr Ala Phe Ala
    2530                2535                2540

 ggt tcc aaa gtc ctg tct ctg atg gat gct gtg gat tgg cag ata aat     7680
 Gly Ser Lys Val Leu Ser Leu Met Asp Ala Val Asp Trp Gln Ile Asn
2545                2550                2555                2560

 aga ggg acc aat aca gtt tta cag aat aat gta gtg gct gga ttt gga     7728
 Arg Gly Thr Asn Thr Val Leu Gln Asn Asn Val Val Ala Gly Phe Gly
                2565                2570                2575

 aga gca gga tac cgc att gat ggt gaa cct tgc cca ggc cag ttt aat     7776
 Arg Ala Gly Tyr Arg Ile Asp Gly Glu Pro Cys Pro Gly Gln Phe Asn
            2580                2585                2590

 cct gtg gaa aag tgg ttt gac aat gaa gcc cat gga ggt tta tat ggg     7824
 Pro Val Glu Lys Trp Phe Asp Asn Glu Ala His Gly Gly Leu Tyr Gly
        2595                2600                2605

 atc tat atg aac caa gat ggc ctt cct gga tgt tct ctt ata caa gga     7872
 Ile Tyr Met Asn Gln Asp Gly Leu Pro Gly Cys Ser Leu Ile Gln Gly
    2610                2615                2620

 ttt acc att tgg aca tgc tgg gat tat gga att tat ttt cag acc aca     7920
 Phe Thr Ile Trp Thr Cys Trp Asp Tyr Gly Ile Tyr Phe Gln Thr Thr
2625                2630                2635                2640

 gag agt gtg cac att tat aat gtg acc ctg gtt gac aat gga atg gcc     7968
 Glu Ser Val His Ile Tyr Asn Val Thr Leu Val Asp Asn Gly Met Ala
                2645                2650                2655

 att ttt cca atg att tac atg cca gct gct ata tca cac aaa att tcc     8016
 Ile Phe Pro Met Ile Tyr Met Pro Ala Ala Ile Ser His Lys Ile Ser
            2660                2665                2670

 agt aaa aat gta caa att aag agc tca tta att gtt gga agt agc cct     8064
 Ser Lys Asn Val Gln Ile Lys Ser Ser Leu Ile Val Gly Ser Ser Pro
        2675                2680                2685

 ggg ttt aat tgc tct gat gtc cta act aat gat gat cct aat att gaa     8112
 Gly Phe Asn Cys Ser Asp Val Leu Thr Asn Asp Asp Pro Asn Ile Glu
    2690                2695                2700

 ctc act gct gct cat cgg agt cct aga tct cca tca ggt tca aca ttt     8160
 Leu Thr Ala Ala His Arg Ser Pro Arg Ser Pro Ser Gly Ser Thr Phe
2705                2710                2715                2720

 gtt gga ttt aag aat gtt tgt tca ggg gaa act aat gtt ata ttc att     8208
 Val Gly Phe Lys Asn Val Cys Ser Gly Glu Thr Asn Val Ile Phe Ile
                2725                2730                2735

 act aac cct tta aat gag gat tta cag cat cca atc cat gtg aag aat     8256
 Thr Asn Pro Leu Asn Glu Asp Leu Gln His Pro Ile His Val Lys Asn
            2740                2745                2750

 ata aaa ctg gtt gat acc act gaa caa tca aaa ata ttt ata cat agg     8304
 Ile Lys Leu Val Asp Thr Thr Glu Gln Ser Lys Ile Phe Ile His Arg
        2755                2760                2765

 cct gat ata agt aag gtc aat cca tct gat tgt gta gac atg gtt tgt     8352
 Pro Asp Ile Ser Lys Val Asn Pro Ser Asp Cys Val Asp Met Val Cys
    2770                2775                2780

 gat gcc aag agg aaa tct ttt ctt aga gac ata gat ggc tcc ttt ctg     8400
 Asp Ala Lys Arg Lys Ser Phe Leu Arg Asp Ile Asp Gly Ser Phe Leu
2785                2790                2795                2800

 ggg aat gct ggt tct gtg ata cct caa gca gaa tat gaa tgg gac gga     8448
 Gly Asn Ala Gly Ser Val Ile Pro Gln Ala Glu Tyr Glu Trp Asp Gly
                2805                2810                2815

 aac agc caa gta gga att gga gac tac aga att cct aag gcg atg ctc     8496
 Asn Ser Gln Val Gly Ile Gly Asp Tyr Arg Ile Pro Lys Ala Met Leu
            2820                2825                2830

 aca ttc ttg aat gga agt aga att cct gtc act gag aaa gca cct cat     8544
 Thr Phe Leu Asn Gly Ser Arg Ile Pro Val Thr Glu Lys Ala Pro His
        2835                2840                2845

 aaa gga att att aga gat tca acc tgt aag tac ctt cca gag tgg cag     8592
 Lys Gly Ile Ile Arg Asp Ser Thr Cys Lys Tyr Leu Pro Glu Trp Gln
    2850                2855                2860

 agc tat cag tgc ttt ggg atg gaa tat gca atg atg gtt att gaa agt     8640
 Ser Tyr Gln Cys Phe Gly Met Glu Tyr Ala Met Met Val Ile Glu Ser
2865                2870                2875                2880

 ctg gat cct gac aca gaa act cga aga ctt tcc cca gtg gct ata atg     8688
 Leu Asp Pro Asp Thr Glu Thr Arg Arg Leu Ser Pro Val Ala Ile Met
                2885                2890                2895

 ggc aac ggt tat gtt gat ctt att aat ggc cca cag gat cat ggc tgg     8736
 Gly Asn Gly Tyr Val Asp Leu Ile Asn Gly Pro Gln Asp His Gly Trp
            2900                2905                2910

 tgt gct gga tat aca tgc cag aga agg ctg tcc ctg ttt cac agc att     8784
 Cys Ala Gly Tyr Thr Cys Gln Arg Arg Leu Ser Leu Phe His Ser Ile
        2915                2920                2925

 gtg gct ctg aac aaa tct tat gaa gtt tac ttc act ggc acc agt cct     8832
 Val Ala Leu Asn Lys Ser Tyr Glu Val Tyr Phe Thr Gly Thr Ser Pro
    2930                2935                2940

 cag aat ctt cga ctg atg ttg ctt aat gtt gat cat aac aag gta ggg     8880
 Gln Asn Leu Arg Leu Met Leu Leu Asn Val Asp His Asn Lys Val Gly
2945                2950                2955                2960

 caa gat gtc tta aga gta att gct gtt gat tat ttg cat gtt att tct     8928
 Gln Asp Val Leu Arg Val Ile Ala Val Asp Tyr Leu His Val Ile Ser
                2965                2970                2975

 atc tgc taa                                                         8937
 Ile Cys 






      <210> 800
      <211> 1203
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (1)..(1203)

      <400> 800
  atg tgg tgc aaa cct tta ccg cca ata cct tgg ctg gcg ctc ggt gca      48
  Met Trp Cys Lys Pro Leu Pro Pro Ile Pro Trp Leu Ala Leu Gly Ala
    1               5                  10                  15

 tcg cca gcg atg gtt atc gaa acc gaa gag gcc agt cag ttt gcg gct       96
 Ser Pro Ala Met Val Ile Glu Thr Glu Glu Ala Ser Gln Phe Ala Ala
              20                  25                  30

 atc gcc agt gcc ttg ttg att aag cgt tgg cac act gac gca gcc acg      144
 Ile Ala Ser Ala Leu Leu Ile Lys Arg Trp His Thr Asp Ala Ala Thr
          35                  40                  45

 cag ctc acg gct gat gcc gtt gct gcg cgt atg tgg gcg atc cat cta      192
 Gln Leu Thr Ala Asp Ala Val Ala Ala Arg Met Trp Ala Ile His Leu
      50                  55                  60

 cgc aga cga gcc tcg cac ggc tat gca gag cgt tgc gca cat ggc tcg      240
 Arg Arg Arg Ala Ser His Gly Tyr Ala Glu Arg Cys Ala His Gly Ser
  65                  70                  75                  80

 tct gtg ttt aca gag cgt cga tgg acg tcg gga ata atc cct tgc tta      288
 Ser Val Phe Thr Glu Arg Arg Trp Thr Ser Gly Ile Ile Pro Cys Leu
                  85                  90                  95

 agt cag cgc ttg aca gcc gac atc tcc ccg tat tcg ctc cag ctg cgc      336
 Ser Gln Arg Leu Thr Ala Asp Ile Ser Pro Tyr Ser Leu Gln Leu Arg
             100                 105                 110

 ggg acc att aat ttt ttt atg gac gat caa acc cag ata ggg tgg agg      384
 Gly Thr Ile Asn Phe Phe Met Asp Asp Gln Thr Gln Ile Gly Trp Arg
         115                 120                 125

 ggc tac cgc acg gct gat tca aaa aca gta aca gag gcg cca gga agg      432
 Gly Tyr Arg Thr Ala Asp Ser Lys Thr Val Thr Glu Ala Pro Gly Arg
     130                 135                 140

 aac atc tgg ggt ctg gcc atg gag ctg gcc ttg gct gca gca aat cct      480
 Asn Ile Trp Gly Leu Ala Met Glu Leu Ala Leu Ala Ala Ala Asn Pro
 145                 150                 155                 160

 tgc cac gcc agt ccc tcc cac atg ctg ggc ttg cac ggc ttt gtg gct      528
 Cys His Ala Ser Pro Ser His Met Leu Gly Leu His Gly Phe Val Ala
                 165                 170                 175

 gca gag gtg tta tgc gcg cac ctg tct gcc agg tca ccg gcc cca tct      576
 Ala Glu Val Leu Cys Ala His Leu Ser Ala Arg Ser Pro Ala Pro Ser
             180                 185                 190

 gct tct acc gca tct atc cac tcc atc agc ctg aca ggc agc ctc aag      624
 Ala Ser Thr Ala Ser Ile His Ser Ile Ser Leu Thr Gly Ser Leu Lys
         195                 200                 205

 gag gcc acc aga ggc tct ccg gct acc cgg cag ctt gac acc gtt gag      672
 Glu Ala Thr Arg Gly Ser Pro Ala Thr Arg Gln Leu Asp Thr Val Glu
     210                 215                 220

 ctg gta atg gct ctg gaa gaa gag ttt gat act gag att ccg gac gaa      720
 Leu Val Met Ala Leu Glu Glu Glu Phe Asp Thr Glu Ile Pro Asp Glu
 225                 230                 235                 240

 gaa gct gag aaa atc acc acc gtt cag gct gcc att gat tac atc aac      768
 Glu Ala Glu Lys Ile Thr Thr Val Gln Ala Ala Ile Asp Tyr Ile Asn
                 245                 250                 255

 ggc cac cag gcg aca aac gtg tct aag cgt cgt gta gtt gtg acc gga      816
 Gly His Gln Ala Thr Asn Val Ser Lys Arg Arg Val Val Val Thr Gly
             260                 265                 270

 ctg ggc atg ttg tct cct gtc ggc aat acc gta gag tct acc tgg aaa      864
 Leu Gly Met Leu Ser Pro Val Gly Asn Thr Val Glu Ser Thr Trp Lys
         275                 280                 285

 gct ctg ctt gcc ggt cag agt ggc atc agc cta atc gac cat ttc gat      912
 Ala Leu Leu Ala Gly Gln Ser Gly Ile Ser Leu Ile Asp His Phe Asp
     290                 295                 300

 act agc gcc tat gca acg aaa ttt gct ggc tta gta aag gat ttt aac      960
 Thr Ser Ala Tyr Ala Thr Lys Phe Ala Gly Leu Val Lys Asp Phe Asn
 305                 310                 315                 320

 tgt gag gac aat gca gga aca aag cag caa gtg gaa ttg gtg cgt gga     1008
 Cys Glu Asp Asn Ala Gly Thr Lys Gln Gln Val Glu Leu Val Arg Gly
                 325                 330                 335

 ggc cac ggc cat tgg cgt gat gtt agc gcc aaa cag aaa tgc ctc tcc     1056
 Gly His Gly His Trp Arg Asp Val Ser Ala Lys Gln Lys Cys Leu Ser
             340                 345                 350

 gtc acg cag aag gac gta gct gtc gct gat att ggc ttt tcc tgc gcg     1104
 Val Thr Gln Lys Asp Val Ala Val Ala Asp Ile Gly Phe Ser Cys Ala
         355                 360                 365

 cag gga ttt aac ttc cca gcc ttg cag ggc aag tcc cgc ttc gaa ctc     1152
 Gln Gly Phe Asn Phe Pro Ala Leu Gln Gly Lys Ser Arg Phe Glu Leu
     370                 375                 380

 ttc ttc gat aaa gta ttc gtg acg aga aag ttc cag aag gaa gtt cct     1200
 Phe Phe Asp Lys Val Phe Val Thr Arg Lys Phe Gln Lys Glu Val Pro
 385                 390                 395                 400

 tag                                                                 1203
 






      <210> 801
      <211> 1395
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (1)..(1395)

      <400> 801
  atg cag cgg gcg cga ccc acg ctc tgg gcc gct gcg ctg act ctg ctg      48
  Met Gln Arg Ala Arg Pro Thr Leu Trp Ala Ala Ala Leu Thr Leu Leu
    1               5                  10                  15

 gtg ctg ctc cgc ggg ccg ccg gtg gcg cgg gct ggc gcg agc tcg gcg       96
 Val Leu Leu Arg Gly Pro Pro Val Ala Arg Ala Gly Ala Ser Ser Ala
              20                  25                  30

 ggc ttg ggt ccc gtg gtg cgc tgc gag ccg tgc gac gcg cgt gca ctg      144
 Gly Leu Gly Pro Val Val Arg Cys Glu Pro Cys Asp Ala Arg Ala Leu
          35                  40                  45

 gcc cag tgc gcg cct ccg ccc gcc gtg tgc gcg gag ctg gtg cgc gag      192
 Ala Gln Cys Ala Pro Pro Pro Ala Val Cys Ala Glu Leu Val Arg Glu
      50                  55                  60

 ccg ggc tgc ggc tgc tgc ctg acg tgc gca ctg agc gag ggc cag ccg      240
 Pro Gly Cys Gly Cys Cys Leu Thr Cys Ala Leu Ser Glu Gly Gln Pro
  65                  70                  75                  80

 tgc ggc atc tac acc gag cgc tgt ggc tcc ggc ctt cgc tgc cag ccg      288
 Cys Gly Ile Tyr Thr Glu Arg Cys Gly Ser Gly Leu Arg Cys Gln Pro
                  85                  90                  95

 tcg ccc gac gag gcg cga ccg ctg cag gcg ctg ctg gac ggc cgc ggg      336
 Ser Pro Asp Glu Ala Arg Pro Leu Gln Ala Leu Leu Asp Gly Arg Gly
             100                 105                 110

 ctc tgc gtc aac gct agt gcc gtc agc cgc ctg cgc gcc tac ctg ctg      384
 Leu Cys Val Asn Ala Ser Ala Val Ser Arg Leu Arg Ala Tyr Leu Leu
         115                 120                 125

 cca gcg ccg cca gct cca gcg tgt tta cct ggt agc att gag gac ggt      432
 Pro Ala Pro Pro Ala Pro Ala Cys Leu Pro Gly Ser Ile Glu Asp Gly
     130                 135                 140

 act ggt caa cct tgg aat tcc cat aag ggc ttg tta caa ctc aga ctg      480
 Thr Gly Gln Pro Trp Asn Ser His Lys Gly Leu Leu Gln Leu Arg Leu
 145                 150                 155                 160

 ctg ccg cca ctc cag cgt ttc cgg agt gga gaa tgt gca ttt ctt cca      528
 Leu Pro Pro Leu Gln Arg Phe Arg Ser Gly Glu Cys Ala Phe Leu Pro
                 165                 170                 175

 agt ccc cgg gct gcc gct gct ccc gcg gga aat gct agt gag tcg gag      576
 Ser Pro Arg Ala Ala Ala Ala Pro Ala Gly Asn Ala Ser Glu Ser Glu
             180                 185                 190

 gaa gac cgc agc gcc ggc agt gtg gag agc ccg tcc gtc tcc agc acg      624
 Glu Asp Arg Ser Ala Gly Ser Val Glu Ser Pro Ser Val Ser Ser Thr
         195                 200                 205

 cac cgg gtg tct gat ccc aag ttc cac ccc ctc cat tca aag ata atc      672
 His Arg Val Ser Asp Pro Lys Phe His Pro Leu His Ser Lys Ile Ile
     210                 215                 220

 atc atc aag aaa ggg cat gct aaa gac agc cag cgc tac aaa gtt gac      720
 Ile Ile Lys Lys Gly His Ala Lys Asp Ser Gln Arg Tyr Lys Val Asp
 225                 230                 235                 240

 tac gag tct cag agc aca gat acc cag aac ttc tcc tcc gag tcc aag      768
 Tyr Glu Ser Gln Ser Thr Asp Thr Gln Asn Phe Ser Ser Glu Ser Lys
                 245                 250                 255

 cgg gag aca gaa tat ggt ccc tgc cgt aga gaa atg gaa gac aca ctg      816
 Arg Glu Thr Glu Tyr Gly Pro Cys Arg Arg Glu Met Glu Asp Thr Leu
             260                 265                 270

 aat cac ctg aag ttc ctc aat gtg ctg agt ccc agg ggt gta cac att      864
 Asn His Leu Lys Phe Leu Asn Val Leu Ser Pro Arg Gly Val His Ile
         275                 280                 285

 ccc aac tgt gac aag aag gga ttt tat aag aaa aag cag cac ata cca      912
 Pro Asn Cys Asp Lys Lys Gly Phe Tyr Lys Lys Lys Gln His Ile Pro
     290                 295                 300

 ggt gtc tgt ctt ggc gtg gag ggg atg gaa ctt gaa atc aga cac tcg      960
 Gly Val Cys Leu Gly Val Glu Gly Met Glu Leu Glu Ile Arg His Ser
 305                 310                 315                 320

 gtc cat gct ggg gat ggc cag tct ctc caa act ggc cat gtg gtc ttc     1008
 Val His Ala Gly Asp Gly Gln Ser Leu Gln Thr Gly His Val Val Phe
                 325                 330                 335

 ctc cga ctc act ggc att tcc cta gaa agt cca aca aaa gaa ccc aag     1056
 Leu Arg Leu Thr Gly Ile Ser Leu Glu Ser Pro Thr Lys Glu Pro Lys
             340                 345                 350

 tca gtt tcc atg gct ttg tgg gaa gcc tat gga ggc att ggg tca tat     1104
 Ser Val Ser Met Ala Leu Trp Glu Ala Tyr Gly Gly Ile Gly Ser Tyr
         355                 360                 365

 ctg caa gat ggt cca att cta gga ggt tgt gtt gtt ggg aca gtc tgt     1152
 Leu Gln Asp Gly Pro Ile Leu Gly Gly Cys Val Val Gly Thr Val Cys
     370                 375                 380

 ggc cca ggt cac atg tac cca agc aac ctg cac gca gac aca cac aga     1200
 Gly Pro Gly His Met Tyr Pro Ser Asn Leu His Ala Asp Thr His Arg
 385                 390                 395                 400

 aat gaa caa gta agg gtg gtc tcc tcc atg gga gtc aag gtg atg cag     1248
 Asn Glu Gln Val Arg Val Val Ser Ser Met Gly Val Lys Val Met Gln
                 405                 410                 415

 gtg cta caa caa cag ctt cct aag att aag tta tca aat caa cac act     1296
 Val Leu Gln Gln Gln Leu Pro Lys Ile Lys Leu Ser Asn Gln His Thr
             420                 425                 430

 tta gga aaa ata aaa atc acc att gtt gat gag ggt acc cta atg gga     1344
 Leu Gly Lys Ile Lys Ile Thr Ile Val Asp Glu Gly Thr Leu Met Gly
         435                 440                 445

 ttc cag gtt ctc tgc tgt ggc agc ctg tct aga ggg aca ttt ctg atc     1392
 Phe Gln Val Leu Cys Cys Gly Ser Leu Ser Arg Gly Thr Phe Leu Ile
     450                 455                 460

 tga                                                                 1395
 






      <210> 802
      <211> 621
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (1)..(621)

      <400> 802
  atg tct tgc tat cag cga cac tca cag aag ttt cat ggt gtg ttt gtt      48
  Met Ser Cys Tyr Gln Arg His Ser Gln Lys Phe His Gly Val Phe Val
    1               5                  10                  15

 gtc tgc ttt gcc ctt ctt act ttt atc caa ggt gta acg cgg cta gct       96
 Val Cys Phe Ala Leu Leu Thr Phe Ile Gln Gly Val Thr Arg Leu Ala
              20                  25                  30

 gat atc agt ttg cat gat cca gtc agt att tct gtc ctg gac aag agc      144
 Asp Ile Ser Leu His Asp Pro Val Ser Ile Ser Val Leu Asp Lys Ser
          35                  40                  45

 cat gac cag ttg aac cca aag gac aaa gcg gtc cag gag gtc tgt cct      192
 His Asp Gln Leu Asn Pro Lys Asp Lys Ala Val Gln Glu Val Cys Pro
      50                  55                  60

 cca cca gct ggc gac aag ctg gac agc ttt gca ata cca gag agt ctc      240
 Pro Pro Ala Gly Asp Lys Leu Asp Ser Phe Ala Ile Pro Glu Ser Leu
  65                  70                  75                  80

 aag cag cat gtg act gtg gtt ccc agc aaa ctg agg ctt gtc tgc cta      288
 Lys Gln His Val Thr Val Val Pro Ser Lys Leu Arg Leu Val Cys Leu
                  85                  90                  95

 gcg gcc ttc atc ctt cag aaa tgc aag ttt gag gaa gac cag aag atg      336
 Ala Ala Phe Ile Leu Gln Lys Cys Lys Phe Glu Glu Asp Gln Lys Met
             100                 105                 110

 gtt gtc ttt ttc tca agt tgc gag ctg gtg gag ttc cac tac agc ctc      384
 Val Val Phe Phe Ser Ser Cys Glu Leu Val Glu Phe His Tyr Ser Leu
         115                 120                 125

 ttc cta cag acc ctg ctg agc agc tca ggg gcg ccg gca tca ggg cag      432
 Phe Leu Gln Thr Leu Leu Ser Ser Ser Gly Ala Pro Ala Ser Gly Gln
     130                 135                 140

 ttg cca tct gcc tcc atg cga tta aaa ttc cta cgg cta cat ggc ggc      480
 Leu Pro Ser Ala Ser Met Arg Leu Lys Phe Leu Arg Leu His Gly Gly
 145                 150                 155                 160

 atg gag cag gag gga ctt ggc tat gtg agt cgc att cct cca ctc tta      528
 Met Glu Gln Glu Gly Leu Gly Tyr Val Ser Arg Ile Pro Pro Leu Leu
                 165                 170                 175

 act agg ccg ttt gtt atg gag tcg ggg tgg aat atg gga gtg aga tat      576
 Thr Arg Pro Phe Val Met Glu Ser Gly Trp Asn Met Gly Val Arg Tyr
             180                 185                 190

 act cac tgg aat tgg gaa aga aag aac gag caa gac tcg aaa tag          621
 Thr His Trp Asn Trp Glu Arg Lys Asn Glu Gln Asp Ser Lys 
         195                 200                 205





      <210> 803
      <211> 1473
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (154)..(1473)

      <400> 803
 tccaaagtgc ttcgggagaa atggctgctg cagggcatac ccgctggaac tgccgaagag     60

 gaggaagcca ggaggcggca gtctgaagag gatgagttca gagtcaagca acttgaagat    120

 aacattcaga gaaggcggtg catcagacgc acc atg act ctg gag gtg ccg gtc     174
                                      Met Thr Leu Glu Val Pro Val
                                        1               5

 ttc agc cta ttg tgg gtg gtc atc atg atg gtc act ggg tta cca gat      222
 Phe Ser Leu Leu Trp Val Val Ile Met Met Val Thr Gly Leu Pro Asp
          10                  15                  20

 gca cgg gtg aaa gag ctg ctc ttg agc aaa ggg cct ggg aca cac atg      270
 Ala Arg Val Lys Glu Leu Leu Leu Ser Lys Gly Pro Gly Thr His Met
      25                  30                  35

 ccg gag aag cat gga aaa agg cag aga gat gcc aga gag aat gca acg      318
 Pro Glu Lys His Gly Lys Arg Gln Arg Asp Ala Arg Glu Asn Ala Thr
  40                  45                  50                  55

 act gtg ccc gtg aga aac caa cag tgc agg gtg gcg atc tac ccg cag      366
 Thr Val Pro Val Arg Asn Gln Gln Cys Arg Val Ala Ile Tyr Pro Gln
                  60                  65                  70

 cac atg cag gat gca gcg tta gat gct gac tca gtt tct cag cca tac      414
 His Met Gln Asp Ala Ala Leu Asp Ala Asp Ser Val Ser Gln Pro Tyr
              75                  80                  85

 agg aga aaa gtt tca gca ttt ctc aaa ctc cat gac cat cct tca gtc      462
 Arg Arg Lys Val Ser Ala Phe Leu Lys Leu His Asp His Pro Ser Val
          90                  95                 100

 ggc tac ccc aag ccc cgt ttt gct gca gcc ggg ctg gag caa gaa ata      510
 Gly Tyr Pro Lys Pro Arg Phe Ala Ala Ala Gly Leu Glu Gln Glu Ile
     105                 110                 115

 caa acg cta gaa agt gaa gag tcc cag ata tct gcc aaa gag caa atc      558
 Gln Thr Leu Glu Ser Glu Glu Ser Gln Ile Ser Ala Lys Glu Gln Ile
 120                 125                 130                 135

 atc cta gag aaa ctg aag gaa aca gaa aaa tcc ttc aag gac ttt cag      606
 Ile Leu Glu Lys Leu Lys Glu Thr Glu Lys Ser Phe Lys Asp Phe Gln
                 140                 145                 150

 aag ggt ttc tcc agt acg gat gga gat gca gta aat tac att tcc tcc      654
 Lys Gly Phe Ser Ser Thr Asp Gly Asp Ala Val Asn Tyr Ile Ser Ser
             155                 160                 165

 cag ctt ccc gac ctg cca atc ctc tgt tca cga aca gca gaa cca tca      702
 Gln Leu Pro Asp Leu Pro Ile Leu Cys Ser Arg Thr Ala Glu Pro Ser
         170                 175                 180

 cct ggg cag gac ggg acc agc aga gcg gct gct gtg tac gcc atg gaa      750
 Pro Gly Gln Asp Gly Thr Ser Arg Ala Ala Ala Val Tyr Ala Met Glu
     185                 190                 195

 att aat gtg gag aaa gac aaa caa aca gga gag acc aag att ctc tct      798
 Ile Asn Val Glu Lys Asp Lys Gln Thr Gly Glu Thr Lys Ile Leu Ser
 200                 205                 210                 215

 aca tct acc att ggc cca gag ggg gtc cat cag aaa gga gtc aaa gtc      846
 Thr Ser Thr Ile Gly Pro Glu Gly Val His Gln Lys Gly Val Lys Val
                 220                 225                 230

 tat gat gat ggt acc aaa gta gtg tat gag gtg cgc tca gga ggc acc      894
 Tyr Asp Asp Gly Thr Lys Val Val Tyr Glu Val Arg Ser Gly Gly Thr
             235                 240                 245

 gta gta gaa aat gga gtg cac aaa tta agc aca aag gat gta gaa gag      942
 Val Val Glu Asn Gly Val His Lys Leu Ser Thr Lys Asp Val Glu Glu
         250                 255                 260

 ctt att cag aag gct gga caa tca agc tta gga gga ggg cac gtg tct      990
 Leu Ile Gln Lys Ala Gly Gln Ser Ser Leu Gly Gly Gly His Val Ser
     265                 270                 275

 gaa agg act gtg att gca gat ggg agc ctc agc cat ccc aag gaa cac     1038
 Glu Arg Thr Val Ile Ala Asp Gly Ser Leu Ser His Pro Lys Glu His
 280                 285                 290                 295

 atg ctc tgc aaa gaa gct aag tta gaa atg gta cat aag tct agg aaa     1086
 Met Leu Cys Lys Glu Ala Lys Leu Glu Met Val His Lys Ser Arg Lys
                 300                 305                 310

 gac cat tct tcc ggg aac cca ggg cag cag gcc caa gcc ccc agc gct     1134
 Asp His Ser Ser Gly Asn Pro Gly Gln Gln Ala Gln Ala Pro Ser Ala
             315                 320                 325

 gca ggg ccg gag gca aac ttg gat cag ccc gtc acc atg att ttt atg     1182
 Ala Gly Pro Glu Ala Asn Leu Asp Gln Pro Val Thr Met Ile Phe Met
         330                 335                 340

 ggc tac caa aat atc gag gat gaa gag gag acg aaa aag gtg cta ggc     1230
 Gly Tyr Gln Asn Ile Glu Asp Glu Glu Glu Thr Lys Lys Val Leu Gly
     345                 350                 355

 tat gat gaa acc atc aag gct gaa ttg gtc ctc att gat gaa gat gat     1278
 Tyr Asp Glu Thr Ile Lys Ala Glu Leu Val Leu Ile Asp Glu Asp Asp
 360                 365                 370                 375

 gag aag tca ttg agg gag aag aca gtg acg gac gtg tcc act att gac     1326
 Glu Lys Ser Leu Arg Glu Lys Thr Val Thr Asp Val Ser Thr Ile Asp
                 380                 385                 390

 ggg aac gcg gct gag ctt gtg tcc ggg agg ccg gtc tca gac acc aca     1374
 Gly Asn Ala Ala Glu Leu Val Ser Gly Arg Pro Val Ser Asp Thr Thr
             395                 400                 405

 gag ccc tca tcc cca gaa ggg aag gaa gag agc cta gct aca gag cca     1422
 Glu Pro Ser Ser Pro Glu Gly Lys Glu Glu Ser Leu Ala Thr Glu Pro
         410                 415                 420

 gcc cca ggt acc caa aag aaa aag cgc tgt caa tgc tgt gtt gtc atg     1470
 Ala Pro Gly Thr Gln Lys Lys Lys Arg Cys Gln Cys Cys Val Val Met
     425                 430                 435

 tga                                                                 1473
 






      <210> 804
      <211> 681
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (1)..(681)

      <400> 804
  atg ggc aca tta cag caa ggt ctg gca tcc gcg gca gcc att tta atg      48
  Met Gly Thr Leu Gln Gln Gly Leu Ala Ser Ala Ala Ala Ile Leu Met
    1               5                  10                  15

 gac tgg cct ctc tta gta ata gat ctt aaa gat tat ttc ttt act ata       96
 Asp Trp Pro Leu Leu Val Ile Asp Leu Lys Asp Tyr Phe Phe Thr Ile
              20                  25                  30

 ccc ttc cac gag aag gat gag cct cga ttt gcc ttc tct gtg ctt tct      144
 Pro Phe His Glu Lys Asp Glu Pro Arg Phe Ala Phe Ser Val Leu Ser
          35                  40                  45

 atc cat caa aga caa cct ggt tct cat tat caa tgg aaa gtt tta cca      192
 Ile His Gln Arg Gln Pro Gly Ser His Tyr Gln Trp Lys Val Leu Pro
      50                  55                  60

 caa ggc atg ctt aac agt cct gtg cta tgt cag cat ttt gta gga cag      240
 Gln Gly Met Leu Asn Ser Pro Val Leu Cys Gln His Phe Val Gly Gln
  65                  70                  75                  80

 gca tta aag gag cct cgg aat atg ttt cct act gct tac atc gtt cat      288
 Ala Leu Lys Glu Pro Arg Asn Met Phe Pro Thr Ala Tyr Ile Val His
                  85                  90                  95

 tat atg gag gat att ctt ttg gcc act cct aca gat caa att tta cat      336
 Tyr Met Glu Asp Ile Leu Leu Ala Thr Pro Thr Asp Gln Ile Leu His
             100                 105                 110

 cag tta ttc aga gaa aca aaa cag gct ttg att aaa tgg aat ctc aaa      384
 Gln Leu Phe Arg Glu Thr Lys Gln Ala Leu Ile Lys Trp Asn Leu Lys
         115                 120                 125

 ata gct cca gaa aag gtg caa aca acc tcc cca cat cgg tac tta agc      432
 Ile Ala Pro Glu Lys Val Gln Thr Thr Ser Pro His Arg Tyr Leu Ser
     130                 135                 140

 act att gtt act gaa aga agt gtt cga ctt cag aaa gta act ctc cgt      480
 Thr Ile Val Thr Glu Arg Ser Val Arg Leu Gln Lys Val Thr Leu Arg
 145                 150                 155                 160

 agg gac aga tta caa aca ctg aaa gat ttc caa caa ttg tta ggg gat      528
 Arg Asp Arg Leu Gln Thr Leu Lys Asp Phe Gln Gln Leu Leu Gly Asp
                 165                 170                 175

 att aat tgg ctg cac ctg atg ata ggt att gct act tat cga ctc aaa      576
 Ile Asn Trp Leu His Leu Met Ile Gly Ile Ala Thr Tyr Arg Leu Lys
             180                 185                 190

 cac ctt tat cag acc ctc caa gga gat tct tca tta gac tct cct tgg      624
 His Leu Tyr Gln Thr Leu Gln Gly Asp Ser Ser Leu Asp Ser Pro Trp
         195                 200                 205

 caa ctt act aag gag gca gaa gct gaa tta cag ctt gta gaa caa atg      672
 Gln Leu Thr Lys Glu Ala Glu Ala Glu Leu Gln Leu Val Glu Gln Met
     210                 215                 220

 ctt cag tga                                                          681
 Leu Gln 
 225





      <210> 805
      <211> 1545
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (710)..(1033)

      <400> 805
 atgacctcta gaatgctggc tcctggaaaa tatcacccaa atatcaacct gttgacaaga     60

 aaaaaaagga cccttgtgat tacactgggc ccattcagtc ctttgaatgc actatgccca    120

 cctcctctcc taagtccttt gacacatctg ggtgtatcca tttggaacac agctgtggtt    180

 aaatgtccac ccctgattca atcagccata gccaaggtag caggcccaca tggattaatt    240

 caaacacttc tgagctgcca gtctgaaact gtgtccggaa ttggtggatt cttggtctca    300

 ctgacttcaa gaatgaagcc gcggaccctc gcagtgagtg ttacagctct taaggtggtg    360

 cgtctggagt ctgtcccttc tgatgttcag atgtgttcgg agttttttcc ttctgactca    420

 ggagcccagc tggcttcacc tagtggatcc cgcaccgggg ctgcaggtga agctgcctgc    480

 cagtcccgca ccttgcgctc gcattcctca gcccttgggt ggtcgatggg actgggcacc    540

 gtggagcagg gggtggtgct tgttggggag gctcgggccg cacaggagcc catggagtgg    600

 gtgggaggct caggcatggc gggctgcagg tcccgagccc tgccccgcgg gaaggcagct    660

 aaggcccgga agattaaggc ttgtaaaaca tctaagcact tggcagcca    ttg act     715
                                                          Met Ala
                                                            1

 ttt ctc aac acc aag gga gtc aga tgt tgt taa tcg gat ttt aca gga      763
 Ala Lys Cys Leu Asp Val Leu Gln Ala Leu Ile Phe Arg Ala Leu Ala
           5                  10                  15

 tta tgg cat ttg gaa ttg tgt ctt cag gga tta tga ctg gca cta gca      811
 Ala Phe Pro Arg Gly Arg Ala Arg Asp Leu Gln Pro Ala Met Pro Glu
      20                  25                  30

 aat ctc tag agg cac aaa gaa tgg aac cgc agc aca ttt gca aaa taa      859
 Pro Pro Thr His Ser Met Gly Ser Cys Ala Ala Arg Ala Ser Pro Thr
  35                  40                  45                  50

 cca agt ttc cac aaa tag tac cca gga aag aga acg cct cat cag caa      907
 Ser Thr Thr Pro Cys Ser Thr Val Pro Ser Pro Ile Asp His Pro Arg
                  55                  60                  65

 aag ttt ctc tga aac aag gtg caa agg aga aag gcg agg ata agg agt      955
 Ala Glu Glu Cys Glu Arg Lys Val Arg Asp Trp Gln Ala Ala Ser Pro
              70                  75                  80

 acc ttc aat gcc gaa ata cct tcc tag aac aaa agg gtg tct tga agc     1003
 Ala Ala Pro Val Arg Asp Pro Leu Gly Glu Ala Ser Trp Ala Pro Glu
          85                  90                  95

 ctt tgc ctc ttt gtc aca tcc gga agg ccc c agccggcaat cagaccttcc     1054
 Ser Glu Gly Lys Asn Ser Glu His Ile 
     100                 105

 ggtgtgagac ctggagctgg ttggccatct gttaccttcc tgcagaagaa gctgacacag   1114

 aagacgaggg ggatagatct ggagccactg ggcagtgcca cctgcaaagc cctgcctcta   1174

 gacttccaat tgtgggagcc cctagggccc aggcacatga cccaggctcc aaagatcaga   1234

 tgcgcctgcc ccagactttc atgcagctgc aggggctgcc cggactttct gggaggaaga   1294

 gcagtggttc cgcttggctt ctagtggctg taatggctgt ggttcctgca gctgtgtttt   1354

 gggtcaggag gaccaacagt gcaagccgta gggtctgtcc agcagccgtt gttgtggtgt   1414

 tgctattgga cacattctac agcatgatta gggacatttt ccctggcagt ggagcctcca   1474

 aacccaagtc ttccactctt gcaaaggtct tccaagttat tgaatacatt cctttttgtt   1534

 tgtttgctta a                                                        1545




      <210> 806
      <211> 4632
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (1)..(4632)

      <400> 806
  atg aat ctg caa tgc atg agc tac tat cat ggt aac atg tcc ctg aca      48
  Met Asn Leu Gln Cys Met Ser Tyr Tyr His Gly Asn Met Ser Leu Thr
    1               5                  10                  15

 ttc ttt gtc agc atc ctt tgt cac ctg ctt gta agg att ttg aaa gag       96
 Phe Phe Val Ser Ile Leu Cys His Leu Leu Val Arg Ile Leu Lys Glu
              20                  25                  30

 atg gag aaa gac atg cct cag tac cta tca gaa ttt agc ctt gag aaa      144
 Met Glu Lys Asp Met Pro Gln Tyr Leu Ser Glu Phe Ser Leu Glu Lys
          35                  40                  45

 aat gag gca acc act gag agt aat gac cct ttt agg gaa tct gtg ctc      192
 Asn Glu Ala Thr Thr Glu Ser Asn Asp Pro Phe Arg Glu Ser Val Leu
      50                  55                  60

 aat tct gaa ctc tat tca gag gcc ttg ggg cag tat atg gtg ctg gtc      240
 Asn Ser Glu Leu Tyr Ser Glu Ala Leu Gly Gln Tyr Met Val Leu Val
  65                  70                  75                  80

 ccc tcc ctg ctc cac act gag gcc cct aag aag ggc tgt gtc ctt ctg      288
 Pro Ser Leu Leu His Thr Glu Ala Pro Lys Lys Gly Cys Val Leu Leu
                  85                  90                  95

 agc cac ctg aat gag aca gtg act gta agt gct tcc ttg gag tct ggc      336
 Ser His Leu Asn Glu Thr Val Thr Val Ser Ala Ser Leu Glu Ser Gly
             100                 105                 110

 agg gaa aac agg agc ctc ttc act gac ctg gtg gcg gag aag gac tta      384
 Arg Glu Asn Arg Ser Leu Phe Thr Asp Leu Val Ala Glu Lys Asp Leu
         115                 120                 125

 ttc cac tgt gtc tcc ttc act ctc cca agg atc tca gcc tct tca gag      432
 Phe His Cys Val Ser Phe Thr Leu Pro Arg Ile Ser Ala Ser Ser Glu
     130                 135                 140

 gtg gca ttc ctt agc atc cag ata aag ggg cct acg caa gat ttc agg      480
 Val Ala Phe Leu Ser Ile Gln Ile Lys Gly Pro Thr Gln Asp Phe Arg
 145                 150                 155                 160

 aag agg aac aca gtt ctg gta ctg aac acc caa agt ctg gtc ttt gtc      528
 Lys Arg Asn Thr Val Leu Val Leu Asn Thr Gln Ser Leu Val Phe Val
                 165                 170                 175

 cag aca gac aaa ccc atg tat aaa cca gga cag aca gta aga ttc cgt      576
 Gln Thr Asp Lys Pro Met Tyr Lys Pro Gly Gln Thr Val Arg Phe Arg
             180                 185                 190

 gtt gtc tcc gtg gat gaa aat ttt cgc cct cga aat gaa ctg att cca      624
 Val Val Ser Val Asp Glu Asn Phe Arg Pro Arg Asn Glu Leu Ile Pro
         195                 200                 205

 ctg ata tac ctt gag aac cca aga aga aat cga att gca caa tgg cag      672
 Leu Ile Tyr Leu Glu Asn Pro Arg Arg Asn Arg Ile Ala Gln Trp Gln
     210                 215                 220

 agt ctc aag cta gaa gct ggc atc aat cag ttg tcc ttt ccc ctc tca      720
 Ser Leu Lys Leu Glu Ala Gly Ile Asn Gln Leu Ser Phe Pro Leu Ser
 225                 230                 235                 240

 tca gag ccc att cag ggc tcc tac agg gtg gtg gta cag aca gaa tca      768
 Ser Glu Pro Ile Gln Gly Ser Tyr Arg Val Val Val Gln Thr Glu Ser
                 245                 250                 255

 ggt gga agg ata cag cac ccc ttc acc gtg gag gaa ttt gtg ctt ccc      816
 Gly Gly Arg Ile Gln His Pro Phe Thr Val Glu Glu Phe Val Leu Pro
             260                 265                 270

 aag ttt gag gtc aaa gtt cag gtg cca aag ata atc agt atc atg gat      864
 Lys Phe Glu Val Lys Val Gln Val Pro Lys Ile Ile Ser Ile Met Asp
         275                 280                 285

 gaa aaa gtg aac ata aca gtc tgt gga gaa tac act tat ggg aag cct      912
 Glu Lys Val Asn Ile Thr Val Cys Gly Glu Tyr Thr Tyr Gly Lys Pro
     290                 295                 300

 gtc cca gga ctt gca act gtg agc ctg tgt aga aaa tta tct cgt gtt      960
 Val Pro Gly Leu Ala Thr Val Ser Leu Cys Arg Lys Leu Ser Arg Val
 305                 310                 315                 320

 ctt aat tgt gac aag cag gag gtc tgt gag gaa ttc agt caa cag ctt     1008
 Leu Asn Cys Asp Lys Gln Glu Val Cys Glu Glu Phe Ser Gln Gln Leu
                 325                 330                 335

 aac agc aat ggc tgc atc acc caa caa gta cac acc aaa atg ctc cag     1056
 Asn Ser Asn Gly Cys Ile Thr Gln Gln Val His Thr Lys Met Leu Gln
             340                 345                 350

 att aca aat acg ggc ttt gaa atg aag ctt aga gtg gaa gcc agg atc     1104
 Ile Thr Asn Thr Gly Phe Glu Met Lys Leu Arg Val Glu Ala Arg Ile
         355                 360                 365

 aga gaa gag ggg aca gac ctg gaa gtc act gca aac agg atc agt gaa     1152
 Arg Glu Glu Gly Thr Asp Leu Glu Val Thr Ala Asn Arg Ile Ser Glu
     370                 375                 380

 atc aca aac att gta tcc aaa ctc aaa ttc gtg aaa gtg gat tca cac     1200
 Ile Thr Asn Ile Val Ser Lys Leu Lys Phe Val Lys Val Asp Ser His
 385                 390                 395                 400

 ttt aga caa gga atc ccc ttt ttt gca cag gtg ctt ctg gtg gat gga     1248
 Phe Arg Gln Gly Ile Pro Phe Phe Ala Gln Val Leu Leu Val Asp Gly
                 405                 410                 415

 aaa ggt gtg ccc atc ccc aat aaa ctc ttc ttc atc tct gtg aat gac     1296
 Lys Gly Val Pro Ile Pro Asn Lys Leu Phe Phe Ile Ser Val Asn Asp
             420                 425                 430

 gcc aat tat tac tcc aat gca acc acc aat gag cag ggt ctt gca cag     1344
 Ala Asn Tyr Tyr Ser Asn Ala Thr Thr Asn Glu Gln Gly Leu Ala Gln
         435                 440                 445

 ttt tca atc aat act acc agt atc tcg gtt aat aaa ctt ttt gtc cgg     1392
 Phe Ser Ile Asn Thr Thr Ser Ile Ser Val Asn Lys Leu Phe Val Arg
     450                 455                 460

 gtt ttc act gtg cat ccc aac ttg tgt ttt cac tat tca tgg gta gca     1440
 Val Phe Thr Val His Pro Asn Leu Cys Phe His Tyr Ser Trp Val Ala
 465                 470                 475                 480

 gaa gac cac cag ggt gct cag cac act gca aat cgt gtt ttc tcc tta     1488
 Glu Asp His Gln Gly Ala Gln His Thr Ala Asn Arg Val Phe Ser Leu
                 485                 490                 495

 agt gga agt tac att cac ctg gag cct gtg gct ggt acc ctg ccc tgt     1536
 Ser Gly Ser Tyr Ile His Leu Glu Pro Val Ala Gly Thr Leu Pro Cys
             500                 505                 510

 ggc cac acg gag act atc acg gca cac tat aca ctg aat aga cag gcc     1584
 Gly His Thr Glu Thr Ile Thr Ala His Tyr Thr Leu Asn Arg Gln Ala
         515                 520                 525

 atg gga gag tta tcg gag ctc agt ttc cat tac ctg atc atg gct aag     1632
 Met Gly Glu Leu Ser Glu Leu Ser Phe His Tyr Leu Ile Met Ala Lys
     530                 535                 540

 gga gtc atc gtc aga tct gga acc cac act ctg cct gtg gag tca gga     1680
 Gly Val Ile Val Arg Ser Gly Thr His Thr Leu Pro Val Glu Ser Gly
 545                 550                 555                 560

 gac atg aaa ggc agt ttt gcc tta tcc ttc cct gtg gag tca gac gtt     1728
 Asp Met Lys Gly Ser Phe Ala Leu Ser Phe Pro Val Glu Ser Asp Val
                 565                 570                 575

 gcc ccc att gca cga atg ttc atc ttt gcc att tta cca gat gga gaa     1776
 Ala Pro Ile Ala Arg Met Phe Ile Phe Ala Ile Leu Pro Asp Gly Glu
             580                 585                 590

 gtt gtt gga gac tct gaa aaa ttt gag att gaa aac tgt cta gcc aac     1824
 Val Val Gly Asp Ser Glu Lys Phe Glu Ile Glu Asn Cys Leu Ala Asn
         595                 600                 605

 aag gtg gat ttg agc ttc agc cca gca caa agt ccc cca gcc tca cat     1872
 Lys Val Asp Leu Ser Phe Ser Pro Ala Gln Ser Pro Pro Ala Ser His
     610                 615                 620

 gcc cac ctg caa gta gca gct gct ccg cag tcc ctc tgt gcc ctt cgt     1920
 Ala His Leu Gln Val Ala Ala Ala Pro Gln Ser Leu Cys Ala Leu Arg
 625                 630                 635                 640

 gct gtg gac caa agt gtg ctg ctc atg aag cct gag gct gag ctc tct     1968
 Ala Val Asp Gln Ser Val Leu Leu Met Lys Pro Glu Ala Glu Leu Ser
                 645                 650                 655

 gtg tcc tca tat gat att ggc tgt gtg ttt gtc ata tat ggc tct tat     2016
 Val Ser Ser Tyr Asp Ile Gly Cys Val Phe Val Ile Tyr Gly Ser Tyr
             660                 665                 670

 gag gta tat aat ctg cta act gtg aag gat ctc acc aat ttt cct gac     2064
 Glu Val Tyr Asn Leu Leu Thr Val Lys Asp Leu Thr Asn Phe Pro Asp
         675                 680                 685

 aat gtg gac cag cag gag gaa gaa caa gga cac tgt ccc cgt cct ttc     2112
 Asn Val Asp Gln Gln Glu Glu Glu Gln Gly His Cys Pro Arg Pro Phe
     690                 695                 700

 ttc att cat aat gga gcc atc tat gtt ccc tta tca agt aat gaa gca     2160
 Phe Ile His Asn Gly Ala Ile Tyr Val Pro Leu Ser Ser Asn Glu Ala
 705                 710                 715                 720

 gat att tat agc ttc ctc aag ggg atg gga ttg aag gtg ttc act aac     2208
 Asp Ile Tyr Ser Phe Leu Lys Gly Met Gly Leu Lys Val Phe Thr Asn
                 725                 730                 735

 tca aaa atc cga aaa cca aag tcg tgt tca gtc atc cct tcc gtg tct     2256
 Ser Lys Ile Arg Lys Pro Lys Ser Cys Ser Val Ile Pro Ser Val Ser
             740                 745                 750

 gca gga gca gta ggt caa gga tac tat gga ggc aca tat aat gtg ata     2304
 Ala Gly Ala Val Gly Gln Gly Tyr Tyr Gly Gly Thr Tyr Asn Val Ile
         755                 760                 765

 ccc tta aat aat gaa caa agt tca ggg cca gtc cct gaa acg gtg cga     2352
 Pro Leu Asn Asn Glu Gln Ser Ser Gly Pro Val Pro Glu Thr Val Arg
     770                 775                 780

 agc tat ttt cct gag act tgg atc tgg gag ttg gtg gca gtg aac tca     2400
 Ser Tyr Phe Pro Glu Thr Trp Ile Trp Glu Leu Val Ala Val Asn Ser
 785                 790                 795                 800

 tca ggt gtg gct gag gta gga gta aca gtc cct gac acc atc acc gag     2448
 Ser Gly Val Ala Glu Val Gly Val Thr Val Pro Asp Thr Ile Thr Glu
                 805                 810                 815

 tgg aag gca ggg gcc ttc tgc ctg tcc gaa gat gct gga ctt ggt atc     2496
 Trp Lys Ala Gly Ala Phe Cys Leu Ser Glu Asp Ala Gly Leu Gly Ile
             820                 825                 830

 tct tcc act gcc tct ctc cga gcc ttc cag ccc ttc ttt gtg gag ctc     2544
 Ser Ser Thr Ala Ser Leu Arg Ala Phe Gln Pro Phe Phe Val Glu Leu
         835                 840                 845

 aca atg cct tac tct gtg att cgt gga gag gtc ttc aca ctc aag gcc     2592
 Thr Met Pro Tyr Ser Val Ile Arg Gly Glu Val Phe Thr Leu Lys Ala
     850                 855                 860

 acg gtc cta aac tac ctt ccc aaa tgc atc cgg gta agg aaa atg agg     2640
 Thr Val Leu Asn Tyr Leu Pro Lys Cys Ile Arg Val Arg Lys Met Arg
 865                 870                 875                 880

 gtg aac agg aaa ggg aat gtg aac ttc tca gtg agt gca gag gca atg     2688
 Val Asn Arg Lys Gly Asn Val Asn Phe Ser Val Ser Ala Glu Ala Met
                 885                 890                 895

 cag tcc tta gaa ctc tgt gga aat gag gtt gtt gag gtc cct gag att     2736
 Gln Ser Leu Glu Leu Cys Gly Asn Glu Val Val Glu Val Pro Glu Ile
             900                 905                 910

 aaa aga aaa gac aca gtc atc aaa acc ctg ttg gtg gag gct gaa ggt     2784
 Lys Arg Lys Asp Thr Val Ile Lys Thr Leu Leu Val Glu Ala Glu Gly
         915                 920                 925

 att gag caa gaa aag act ttc agt tct atg acc tgt gcc tca ggt gct     2832
 Ile Glu Gln Glu Lys Thr Phe Ser Ser Met Thr Cys Ala Ser Gly Ala
     930                 935                 940

 aat gtg tct gag cag ttg tcc ttg aag ctc cca tca aat gtg gtc aaa     2880
 Asn Val Ser Glu Gln Leu Ser Leu Lys Leu Pro Ser Asn Val Val Lys
 945                 950                 955                 960

 gaa tct gcc aga gct tct ttc tca gtt ctg ggt gac ata tta ggt tct     2928
 Glu Ser Ala Arg Ala Ser Phe Ser Val Leu Gly Asp Ile Leu Gly Ser
                 965                 970                 975

 gct atg caa aat ata caa aat ctc ctc cag atg cca tat ggc tgt gga     2976
 Ala Met Gln Asn Ile Gln Asn Leu Leu Gln Met Pro Tyr Gly Cys Gly
             980                 985                 990

 gaa cag aac atg gtc cta ttt gct cct aac atc tat gtc ttg aac tat     3024
 Glu Gln Asn Met Val Leu Phe Ala Pro Asn Ile Tyr Val Leu Asn Tyr
         995                1000                1005

 ctg aat gaa acc cag cag ctg acg cag gag atc aag gcc aag gcc gtt     3072
 Leu Asn Glu Thr Gln Gln Leu Thr Gln Glu Ile Lys Ala Lys Ala Val
    1010                1015                1020

 ggc tat ctc atc act ggt tac cag aga cag ctg aac tac aaa cac caa     3120
 Gly Tyr Leu Ile Thr Gly Tyr Gln Arg Gln Leu Asn Tyr Lys His Gln
1025                1030                1035                1040

 gat ggc tcc tac agc acc ttt ggg gaa cga tat ggc agg aac cag ggc     3168
 Asp Gly Ser Tyr Ser Thr Phe Gly Glu Arg Tyr Gly Arg Asn Gln Gly
                1045                1050                1055

 aac act tgg ctc aca gct ttt gta ctg aag act ttc gcc cag gct cga     3216
 Asn Thr Trp Leu Thr Ala Phe Val Leu Lys Thr Phe Ala Gln Ala Arg
            1060                1065                1070

 tcc tac atc ttc att gat gaa gca cac att acc caa tct ctc acg tgg     3264
 Ser Tyr Ile Phe Ile Asp Glu Ala His Ile Thr Gln Ser Leu Thr Trp
        1075                1080                1085

 ctc tcc cag atg cag aag gac aat ggc tgt ttc agg agc tct ggg tca     3312
 Leu Ser Gln Met Gln Lys Asp Asn Gly Cys Phe Arg Ser Ser Gly Ser
    1090                1095                1100

 ctg ctc aac aat gcc ata aag aac cct att gtt cgc aat gcc ctg ttc     3360
 Leu Leu Asn Asn Ala Ile Lys Asn Pro Ile Val Arg Asn Ala Leu Phe
1105                1110                1115                1120

 tgc ctg gag tca gcc tgg aat gta gca aag gag ggg acc cat ggg agc     3408
 Cys Leu Glu Ser Ala Trp Asn Val Ala Lys Glu Gly Thr His Gly Ser
                1125                1130                1135

 cat gtc tac acc aag gca ttg ctg gcc tat gct ttt tcc cta ctg gga     3456
 His Val Tyr Thr Lys Ala Leu Leu Ala Tyr Ala Phe Ser Leu Leu Gly
            1140                1145                1150

 aag caa aat cag aat aga gaa ata ctg aac tca ctt gat aag gaa gct     3504
 Lys Gln Asn Gln Asn Arg Glu Ile Leu Asn Ser Leu Asp Lys Glu Ala
        1155                1160                1165

 gtg aaa gaa gat cca gag atg gag gaa gga ctg tgc ctg gag gtg gag     3552
 Val Lys Glu Asp Pro Glu Met Glu Glu Gly Leu Cys Leu Glu Val Glu
    1170                1175                1180

 ggg aag atg gtc agt agg aca aag ggt gac att gat gac tcg ctt att     3600
 Gly Lys Met Val Ser Arg Thr Lys Gly Asp Ile Asp Asp Ser Leu Ile
1185                1190                1195                1200

 ggt gga gat gcc ttc act gaa gtt tcc caa agc gaa gcc aaa agg tca     3648
 Gly Gly Asp Ala Phe Thr Glu Val Ser Gln Ser Glu Ala Lys Arg Ser
                1205                1210                1215

 aga agc aat aaa aac tac cag ttc ttt att ggt gaa aac atg aac cca     3696
 Arg Ser Asn Lys Asn Tyr Gln Phe Phe Ile Gly Glu Asn Met Asn Pro
            1220                1225                1230

 tat ggc atg ctg cct ctg ctg gac tac cat gag gat gac aac ctc gtc     3744
 Tyr Gly Met Leu Pro Leu Leu Asp Tyr His Glu Asp Asp Asn Leu Val
        1235                1240                1245

 cat tgg gag cgc cct cag aga ccc aag gca cca gtg ggg cat ctt tac     3792
 His Trp Glu Arg Pro Gln Arg Pro Lys Ala Pro Val Gly His Leu Tyr
    1250                1255                1260

 caa acc cag gct ccc tct gct gag gtg gag atg aca tcc tat gtg ctc     3840
 Gln Thr Gln Ala Pro Ser Ala Glu Val Glu Met Thr Ser Tyr Val Leu
1265                1270                1275                1280

 ctc gct tat ctc acg gcc cag cca gcc ccc acc tca ggg gac ctg acc     3888
 Leu Ala Tyr Leu Thr Ala Gln Pro Ala Pro Thr Ser Gly Asp Leu Thr
                1285                1290                1295

 tct gca act aac att gtg aag tgg atc atg aag cag cag aac gcc caa     3936
 Ser Ala Thr Asn Ile Val Lys Trp Ile Met Lys Gln Gln Asn Ala Gln
            1300                1305                1310

 ggt ggt ttc tcc tcc acc cag gac aca gtg gtg gct ctc cat gcc ctg     3984
 Gly Gly Phe Ser Ser Thr Gln Asp Thr Val Val Ala Leu His Ala Leu
        1315                1320                1325

 tcc agg tat gga gca gcc act ttc acc aga act gag aaa act gca cag     4032
 Ser Arg Tyr Gly Ala Ala Thr Phe Thr Arg Thr Glu Lys Thr Ala Gln
    1330                1335                1340

 gtc acc gtt cag gat tca cag acc ttt tct aca aat ttc caa gta gac     4080
 Val Thr Val Gln Asp Ser Gln Thr Phe Ser Thr Asn Phe Gln Val Asp
1345                1350                1355                1360

 aac aac aac ctc cta tta ctg cag cag atc tca ttg cca gag ctc cct     4128
 Asn Asn Asn Leu Leu Leu Leu Gln Gln Ile Ser Leu Pro Glu Leu Pro
                1365                1370                1375

 gga gaa tat gtc ata aca gta act ggg gaa aga tgt gtg tat ctt cag     4176
 Gly Glu Tyr Val Ile Thr Val Thr Gly Glu Arg Cys Val Tyr Leu Gln
            1380                1385                1390

 aca tcc atg aaa tac aat att ctt cca gag aaa gag gac tcc cca ttt     4224
 Thr Ser Met Lys Tyr Asn Ile Leu Pro Glu Lys Glu Asp Ser Pro Phe
        1395                1400                1405

 gct tta aaa gtg cag act gtg ccc caa act tgc gat gga cac aaa gcc     4272
 Ala Leu Lys Val Gln Thr Val Pro Gln Thr Cys Asp Gly His Lys Ala
    1410                1415                1420

 cac acc agc ttt cag atc tca ctg acc atc agt tac aca gga aac cgt     4320
 His Thr Ser Phe Gln Ile Ser Leu Thr Ile Ser Tyr Thr Gly Asn Arg
1425                1430                1435                1440

 cct gct tcc aat atg gtg att gtt gat gta aag atg gta tct ggt ttt     4368
 Pro Ala Ser Asn Met Val Ile Val Asp Val Lys Met Val Ser Gly Phe
                1445                1450                1455

 att ccc ctg aaa cca aca gta aaa atg ctt gaa aga tct agc tct gtg     4416
 Ile Pro Leu Lys Pro Thr Val Lys Met Leu Glu Arg Ser Ser Ser Val
            1460                1465                1470

 agc cgg aca gaa gtg agc aac aac cat gtc ctc att tat gtg gaa cag     4464
 Ser Arg Thr Glu Val Ser Asn Asn His Val Leu Ile Tyr Val Glu Gln
        1475                1480                1485

 gtg aca aat cag acg cta agt ttt tcc ttc atg gtt ctg caa gac atc     4512
 Val Thr Asn Gln Thr Leu Ser Phe Ser Phe Met Val Leu Gln Asp Ile
    1490                1495                1500

 cca gta gga gac ttg aag cca gca att gtt aaa gtc tat gat tac tat     4560
 Pro Val Gly Asp Leu Lys Pro Ala Ile Val Lys Val Tyr Asp Tyr Tyr
1505                1510                1515                1520

 gag aca gat gag tct gtg gtt gct gag tat atc gcc ccc tgc agc aca     4608
 Glu Thr Asp Glu Ser Val Val Ala Glu Tyr Ile Ala Pro Cys Ser Thr
                1525                1530                1535

 gat aca gag cat gga aat gtt tga                                     4632
 Asp Thr Glu His Gly Asn Val 
            1540





      <210> 807
      <211> 1845
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (1)..(1845)

      <400> 807
  atg agg ccg agg ccc gaa ggt agg ggg ctc cgg gcg gga gtc gcg ctg      48
  Met Arg Pro Arg Pro Glu Gly Arg Gly Leu Arg Ala Gly Val Ala Leu
    1               5                  10                  15

 tcc ccc gcg cta ctg ctg ctg ctg ctg ctg ccg ccg ccg ccg acg ctg       96
 Ser Pro Ala Leu Leu Leu Leu Leu Leu Leu Pro Pro Pro Pro Thr Leu
              20                  25                  30

 ctg ggg cgc ctg tgg gca gcg ggc aca ccc tcg ccg tcg gcg ccc gga      144
 Leu Gly Arg Leu Trp Ala Ala Gly Thr Pro Ser Pro Ser Ala Pro Gly
          35                  40                  45

 gct cgg cag gac ggc gcg ctg gga gcc ggc cgc gtc aaa cgc ggc tgg      192
 Ala Arg Gln Asp Gly Ala Leu Gly Ala Gly Arg Val Lys Arg Gly Trp
      50                  55                  60

 gtg tgg aac cag ttc ttc gtg gta gag gag tac acg ggc acg gag ccc      240
 Val Trp Asn Gln Phe Phe Val Val Glu Glu Tyr Thr Gly Thr Glu Pro
  65                  70                  75                  80

 ctg tat gtg ggc aag atc cac tcc gac tca gac gag ggt gac ggg gcc      288
 Leu Tyr Val Gly Lys Ile His Ser Asp Ser Asp Glu Gly Asp Gly Ala
                  85                  90                  95

 atc aag tac acc atc tca ggc gag ggt gct ggg acc atc ttc ctg atc      336
 Ile Lys Tyr Thr Ile Ser Gly Glu Gly Ala Gly Thr Ile Phe Leu Ile
             100                 105                 110

 gac gag ctg aca ggc gac att cat gcc atg gag cgc ctg gac cgc gag      384
 Asp Glu Leu Thr Gly Asp Ile His Ala Met Glu Arg Leu Asp Arg Glu
         115                 120                 125

 cag aaa acc ttc tac acg ctg cgg gcc cag gct cgg gat cgc gcc acc      432
 Gln Lys Thr Phe Tyr Thr Leu Arg Ala Gln Ala Arg Asp Arg Ala Thr
     130                 135                 140

 aac cgc cta ctg gag ccc gag tcg gag ttc atc atc aag gtg cag gac      480
 Asn Arg Leu Leu Glu Pro Glu Ser Glu Phe Ile Ile Lys Val Gln Asp
 145                 150                 155                 160

 atc aat gac agt gag ccc cgc ttc ctg cac ggc ccc tat att ggc agc      528
 Ile Asn Asp Ser Glu Pro Arg Phe Leu His Gly Pro Tyr Ile Gly Ser
                 165                 170                 175

 gtg gcc gag ctc tca cct aca ggc acg tcg gtg atg cag gtg atg gcc      576
 Val Ala Glu Leu Ser Pro Thr Gly Thr Ser Val Met Gln Val Met Ala
             180                 185                 190

 tcg gat gcg gat gac ccc acg tac ggc agc agc gct cgg ctg gtg tac      624
 Ser Asp Ala Asp Asp Pro Thr Tyr Gly Ser Ser Ala Arg Leu Val Tyr
         195                 200                 205

 agc gtg ctg gac ggc gag cac cac ttc acc gtg gac ccc aag acc gaa      672
 Ser Val Leu Asp Gly Glu His His Phe Thr Val Asp Pro Lys Thr Glu
     210                 215                 220

 gaa gaa gaa gaa gaa gaa gaa gaa gaa gaa gaa gaa gaa gaa gaa gaa      720
 Glu Glu Glu Glu Glu Glu Glu Glu Glu Glu Glu Glu Glu Glu Glu Glu
 225                 230                 235                 240

 gaa gaa gaa ggt gtt gcc aga cca aga ttt cag aga agg gca ttc cag      768
 Glu Glu Glu Gly Val Ala Arg Pro Arg Phe Gln Arg Arg Ala Phe Gln
                 245                 250                 255

 gat aat ttt cag gaa gtg gag aag ctt ggt caa aga gca cat gca ttc      816
 Asp Asn Phe Gln Glu Val Glu Lys Leu Gly Gln Arg Ala His Ala Phe
             260                 265                 270

 gga atc tcg ata gat aat gcc gaa atg tac cag acg aca ctc ccg ccc      864
 Gly Ile Ser Ile Asp Asn Ala Glu Met Tyr Gln Thr Thr Leu Pro Pro
         275                 280                 285

 tat aga cac ggg atg aac aag acc agc atg gat ttc tgc ctc tgt gaa      912
 Tyr Arg His Gly Met Asn Lys Thr Ser Met Asp Phe Cys Leu Cys Glu
     290                 295                 300

 act tgt tta tgg agg tac tca atc cag aac ttg agg aaa gag atc agc      960
 Thr Cys Leu Trp Arg Tyr Ser Ile Gln Asn Leu Arg Lys Glu Ile Ser
 305                 310                 315                 320

 aag gca tct cca aaa tgt gag gcc tgc tgc tgg aag ctt cct ctc att     1008
 Lys Ala Ser Pro Lys Cys Glu Ala Cys Cys Trp Lys Leu Pro Leu Ile
                 325                 330                 335

 cag tcc tct caa cag ccc tac cag ggt gga gaa tat gac aca ccc cac     1056
 Gln Ser Ser Gln Gln Pro Tyr Gln Gly Gly Glu Tyr Asp Thr Pro His
             340                 345                 350

 ctt ccc tgt aca gcc cct gct gtc cag ggc tgc aaa gcc tca gcg tcc     1104
 Leu Pro Cys Thr Ala Pro Ala Val Gln Gly Cys Lys Ala Ser Ala Ser
         355                 360                 365

 tgg cta tgc act ttc tac acg tgt gac ctt caa caa ggc gta atc cgg     1152
 Trp Leu Cys Thr Phe Tyr Thr Cys Asp Leu Gln Gln Gly Val Ile Arg
     370                 375                 380

 acg gct gtg cct gac ctt gac cgc gag agc cag gag cgc tac gag gtg     1200
 Thr Ala Val Pro Asp Leu Asp Arg Glu Ser Gln Glu Arg Tyr Glu Val
 385                 390                 395                 400

 gtg atc cag gcc aca gac atg gcg ggt cag ctg ggt ggc ctc tcg ggc     1248
 Val Ile Gln Ala Thr Asp Met Ala Gly Gln Leu Gly Gly Leu Ser Gly
                 405                 410                 415

 tcc act acc gtc acc atc gta gtc acc gac gtc aat gac aac ccg ccc     1296
 Ser Thr Thr Val Thr Ile Val Val Thr Asp Val Asn Asp Asn Pro Pro
             420                 425                 430

 cgt ttc ccg cag aag atg tac cag ttc agc atc cag gag tca gcc ccc     1344
 Arg Phe Pro Gln Lys Met Tyr Gln Phe Ser Ile Gln Glu Ser Ala Pro
         435                 440                 445

 att gga acg gct gtg gga cgt gtg aag gct gag gac tca gac gtg gga     1392
 Ile Gly Thr Ala Val Gly Arg Val Lys Ala Glu Asp Ser Asp Val Gly
     450                 455                 460

 gag aac aca gac atg act tac cac ctt aag gac gag agc agc agc ggc     1440
 Glu Asn Thr Asp Met Thr Tyr His Leu Lys Asp Glu Ser Ser Ser Gly
 465                 470                 475                 480

 ggc gat gtg ttc aag gtc acc aca gac agc gac act cag gag gcc atc     1488
 Gly Asp Val Phe Lys Val Thr Thr Asp Ser Asp Thr Gln Glu Ala Ile
                 485                 490                 495

 atc gta gtg cag aag cgc ctg gac ttc gaa tcc cag ccc gtg cac acc     1536
 Ile Val Val Gln Lys Arg Leu Asp Phe Glu Ser Gln Pro Val His Thr
             500                 505                 510

 gtg atc ctg gag gcc ctc aac aag ttc gtg gac ccc cgc ttc gcc gac     1584
 Val Ile Leu Glu Ala Leu Asn Lys Phe Val Asp Pro Arg Phe Ala Asp
         515                 520                 525

 ctg ggc acg ttc cgc gac cag gcg atc gtg cgc gtg gcc gtg acc gac     1632
 Leu Gly Thr Phe Arg Asp Gln Ala Ile Val Arg Val Ala Val Thr Asp
     530                 535                 540

 gtg gac gag ccc ccc gag ttc cgg ccg ccc tcc ggc ctc ctg gag gtg     1680
 Val Asp Glu Pro Pro Glu Phe Arg Pro Pro Ser Gly Leu Leu Glu Val
 545                 550                 555                 560

 cag gag gac gcg cag gtg ggc tcc ctg gtc ggc gtg gtg acg gcg cgg     1728
 Gln Glu Asp Ala Gln Val Gly Ser Leu Val Gly Val Val Thr Ala Arg
                 565                 570                 575

 gac ccc gac gcc gcc aac cgg ccc gtc cga att gtt gca gga gcc agc     1776
 Asp Pro Asp Ala Ala Asn Arg Pro Val Arg Ile Val Ala Gly Ala Ser
             580                 585                 590

 ctg atc ctg ctc aaa tgt gaa cta gag cct ggc cct gct ctg ccc aag     1824
 Leu Ile Leu Leu Lys Cys Glu Leu Glu Pro Gly Pro Ala Leu Pro Lys
         595                 600                 605

 ccc tcc aaa gac acc tac tag                                         1845
 Pro Ser Lys Asp Thr Tyr 
     610





      <210> 808
      <211> 777
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (1)..(777)

      <400> 808
  atg aag aac ctg ccg agg gcc tgt tct gcc ctg ccg agg ctg ctc gcg      48
  Met Lys Asn Leu Pro Arg Ala Cys Ser Ala Leu Pro Arg Leu Leu Ala
    1               5                  10                  15

 ctc tcg tgg tac tcc ctt aag cat ata cga tta ggg tca tat tcg gga       96
 Leu Ser Trp Tyr Ser Leu Lys His Ile Arg Leu Gly Ser Tyr Ser Gly
              20                  25                  30

 aca gga atg ggg ttt aat agg gct ctt gag aaa gca aga atg aaa cag      144
 Thr Gly Met Gly Phe Asn Arg Ala Leu Glu Lys Ala Arg Met Lys Gln
          35                  40                  45

 gaa atc tgg aaa cct ggg ccc agg ctc cag cgc tgg ctg att aag ggt      192
 Glu Ile Trp Lys Pro Gly Pro Arg Leu Gln Arg Trp Leu Ile Lys Gly
      50                  55                  60

 ctg ggc aag gtt atc cca tgt ctc acc cct gtg gtc tcc ata cag cac      240
 Leu Gly Lys Val Ile Pro Cys Leu Thr Pro Val Val Ser Ile Gln His
  65                  70                  75                  80

 cta ctg gtt acc aag ctc tca gct ttc cag ggc atc ata gtg aca ggt      288
 Leu Leu Val Thr Lys Leu Ser Ala Phe Gln Gly Ile Ile Val Thr Gly
                  85                  90                  95

 gac ata gtg aca ggt gac cat gag gac atg gtc ccg ctg atc ctc acc      336
 Asp Ile Val Thr Gly Asp His Glu Asp Met Val Pro Leu Ile Leu Thr
             100                 105                 110

 act gac agc aag agg gac ttt ctg gcc agg gag agg ttg cag ggt cat      384
 Thr Asp Ser Lys Arg Asp Phe Leu Ala Arg Glu Arg Leu Gln Gly His
         115                 120                 125

 ctg gcc tgg gct cca ggg gaa aac caa cct gtg atc cat gtg ctc atc      432
 Leu Ala Trp Ala Pro Gly Glu Asn Gln Pro Val Ile His Val Leu Ile
     130                 135                 140

 agg gaa ccc acc aag gtt aag gtg agg tct gtg cag ctg cag act cct      480
 Arg Glu Pro Thr Lys Val Lys Val Arg Ser Val Gln Leu Gln Thr Pro
 145                 150                 155                 160

 ccc caa acc agc gag cca cag tgt ggg gac aag gaa cgc agc tcc tca      528
 Pro Gln Thr Ser Glu Pro Gln Cys Gly Asp Lys Glu Arg Ser Ser Ser
                 165                 170                 175

 cca gca atg gaa caa agc tgg acg gag aat gac ttt gat gag ttg aga      576
 Pro Ala Met Glu Gln Ser Trp Thr Glu Asn Asp Phe Asp Glu Leu Arg
             180                 185                 190

 gaa gaa gga ttc aga aaa tca aac ttc tct gag cta aag gag gaa gtt      624
 Glu Glu Gly Phe Arg Lys Ser Asn Phe Ser Glu Leu Lys Glu Glu Val
         195                 200                 205

 cga atc cat ggc aaa gaa gtt aaa aac ctt gaa aaa aga tta aac aga      672
 Arg Ile His Gly Lys Glu Val Lys Asn Leu Glu Lys Arg Leu Asn Arg
     210                 215                 220

 ggg cta act aaa ata acc aat gca gag aag tcc tta aag gac ctg gtg      720
 Gly Leu Thr Lys Ile Thr Asn Ala Glu Lys Ser Leu Lys Asp Leu Val
 225                 230                 235                 240

 gag ctg aaa acc atg gca caa gaa cta cat gac gaa tgc aca agc ttc      768
 Glu Leu Lys Thr Met Ala Gln Glu Leu His Asp Glu Cys Thr Ser Phe
                 245                 250                 255

 agt agc tga                                                          777
 Ser Ser 








      <210> 809
      <211> 441
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (1)..(441)

      <400> 809
  atg cag atg act ggg ccc atc tca gat cta tgg acg cac atg tct gaa      48
  Met Gln Met Thr Gly Pro Ile Ser Asp Leu Trp Thr His Met Ser Glu
    1               5                  10                  15

 ccc ctg ggc cct gtg gaa ctt gcc ctc act agc atc ctg acc ttg ctg       96
 Pro Leu Gly Pro Val Glu Leu Ala Leu Thr Ser Ile Leu Thr Leu Leu
              20                  25                  30

 gcg ctg ggc tcc att gcc atc ttc ctg gag gat gcc gtc tac ctg tac      144
 Ala Leu Gly Ser Ile Ala Ile Phe Leu Glu Asp Ala Val Tyr Leu Tyr
          35                  40                  45

 aag aac acc ctt tgc ccc atc aag agg cgg act ctg ctc tgg aag agc      192
 Lys Asn Thr Leu Cys Pro Ile Lys Arg Arg Thr Leu Leu Trp Lys Ser
      50                  55                  60

 tcg gca ccc acg gtg gtg tct gtg ctg tgc tgc ttt ggt ctc tgg atc      240
 Ser Ala Pro Thr Val Val Ser Val Leu Cys Cys Phe Gly Leu Trp Ile
  65                  70                  75                  80

 cct cgt tcc ctg gtg ctg gtg gaa atg acc atc acc tcg ttt tat gcc      288
 Pro Arg Ser Leu Val Leu Val Glu Met Thr Ile Thr Ser Phe Tyr Ala
                  85                  90                  95

 gtg tgc ttt tac ctg ctg atg ctg gtc atg gtg gaa ggc ttt ggg ggg      336
 Val Cys Phe Tyr Leu Leu Met Leu Val Met Val Glu Gly Phe Gly Gly
             100                 105                 110

 aag gag gca gtg ctg agg acg ctg agg gac acc ccg atg atg gtc cac      384
 Lys Glu Ala Val Leu Arg Thr Leu Arg Asp Thr Pro Met Met Val His
         115                 120                 125

 aca ggc ccc tgc tgc tgc tgc tgc ccc tgc tgt cca cgg ctg ctg ctc      432
 Thr Gly Pro Cys Cys Cys Cys Cys Pro Cys Cys Pro Arg Leu Leu Leu
     130                 135                 140

 acc agg tga                                                          441
 Thr Arg 
 145





      <210> 810
      <211> 888
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (1)..(888)

      <400> 810
  atg gat aaa gtt gat gaa gtc tcg cct tgc gct ttt cag act gcg gtt      48
  Met Asp Lys Val Asp Glu Val Ser Pro Cys Ala Phe Gln Thr Ala Val
    1               5                  10                  15

 gtt cag aag ctc tta gtt tgt ggg ctg tcc ttg tta ttt cac ttg acc       96
 Val Gln Lys Leu Leu Val Cys Gly Leu Ser Leu Leu Phe His Leu Thr
              20                  25                  30

 atc tgt aca aca tta cct gtg gag tac aac att gat gag cat ttt caa      144
 Ile Cys Thr Thr Leu Pro Val Glu Tyr Asn Ile Asp Glu His Phe Gln
          35                  40                  45

 gct aca gct tcg tgg cca aca aag att atc tat ctg tat atc tct ctt      192
 Ala Thr Ala Ser Trp Pro Thr Lys Ile Ile Tyr Leu Tyr Ile Ser Leu
      50                  55                  60

 ttg gct gcc aga ccc aaa tac tat ttt gca tgg acg cta gct gat gcc      240
 Leu Ala Ala Arg Pro Lys Tyr Tyr Phe Ala Trp Thr Leu Ala Asp Ala
  65                  70                  75                  80

 att aat aat gct gca ggc ttt ggt ttc aga ggg tat gac gaa aat gga      288
 Ile Asn Asn Ala Ala Gly Phe Gly Phe Arg Gly Tyr Asp Glu Asn Gly
                  85                  90                  95

 gca gct cgc tgg gac tta att tcc aat ttg aga att caa caa ata gag      336
 Ala Ala Arg Trp Asp Leu Ile Ser Asn Leu Arg Ile Gln Gln Ile Glu
             100                 105                 110

 gtt tat ggt gat agc ttc cac tta gat aag gaa cag aga ata gat atg      384
 Val Tyr Gly Asp Ser Phe His Leu Asp Lys Glu Gln Arg Ile Asp Met
         115                 120                 125

 agt ttg aag gga cag ata ata tct tca aat cac aga ctt agt gag ttg      432
 Ser Leu Lys Gly Gln Ile Ile Ser Ser Asn His Arg Leu Ser Glu Leu
     130                 135                 140

 tcc acg agg cag atc atg gtc aga cac tca gca gag gca ccc gag ctt      480
 Ser Thr Arg Gln Ile Met Val Arg His Ser Ala Glu Ala Pro Glu Leu
 145                 150                 155                 160

 gag agt gaa atc tgg gaa cta tca gca cgt ggc agt tca ggc cct gga      528
 Glu Ser Glu Ile Trp Glu Leu Ser Ala Arg Gly Ser Ser Gly Pro Gly
                 165                 170                 175

 gga gag aat cag aag aga tgt caa caa gtt tca aga tgt ttc ttg ata      576
 Gly Glu Asn Gln Lys Arg Cys Gln Gln Val Ser Arg Cys Phe Leu Ile
             180                 185                 190

 att gga ata ttc aga cag ctc ttt ggc tca aaa gaa ttt tct gaa gga      624
 Ile Gly Ile Phe Arg Gln Leu Phe Gly Ser Lys Glu Phe Ser Glu Gly
         195                 200                 205

 gag ata aaa act gag tta aat aaa gat gat cag aat ggc tcc tgg tat      672
 Glu Ile Lys Thr Glu Leu Asn Lys Asp Asp Gln Asn Gly Ser Trp Tyr
     210                 215                 220

 tat tgc ctg cac att ctt ggt atc tta gta tta ttg ttg ttg cca gtg      720
 Tyr Cys Leu His Ile Leu Gly Ile Leu Val Leu Leu Leu Leu Pro Val
 225                 230                 235                 240

 aaa aaa act caa aga aga aag aat aca cat gaa aac att cag ctc tca      768
 Lys Lys Thr Gln Arg Arg Lys Asn Thr His Glu Asn Ile Gln Leu Ser
                 245                 250                 255

 caa tcc aaa aag ttt gat gaa gga gaa aat tct ttg gga cag aac agt      816
 Gln Ser Lys Lys Phe Asp Glu Gly Glu Asn Ser Leu Gly Gln Asn Ser
             260                 265                 270

 ttt tct aca aca aac aat gtt tgc aat cag aat caa gaa ata gcc tcg      864
 Phe Ser Thr Thr Asn Asn Val Cys Asn Gln Asn Gln Glu Ile Ala Ser
         275                 280                 285

 aga cat tca tca cta aag cag tga                                      888
 Arg His Ser Ser Leu Lys Gln 
     290                 295





      <210> 811
      <211> 1602
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (1)..(1602)

      <400> 811
  atg ctt ggc gtg gct ttg gtg gca ggc gcg ctg ggg gct gga gta gtg      48
  Met Leu Gly Val Ala Leu Val Ala Gly Ala Leu Gly Ala Gly Val Val
    1               5                  10                  15

 gct gcg gcg gcg gca ctg ctg ctg gtg gcg ctg gct gta gca ccc gcc       96
 Ala Ala Ala Ala Ala Leu Leu Leu Val Ala Leu Ala Val Ala Pro Ala
              20                  25                  30

 att gcc ttg tgt tgg ggg gcg gtg ctg gcc tcc ccg gct gtg tat ctg      144
 Ile Ala Leu Cys Trp Gly Ala Val Leu Ala Ser Pro Ala Val Tyr Leu
          35                  40                  45

 atc cta gac ggg gtc gtg gtt gcg gca ttt gtg gtt gta gcg gtc tgt      192
 Ile Leu Asp Gly Val Val Val Ala Ala Phe Val Val Val Ala Val Cys
      50                  55                  60

 act gac cgc agc agt ggt gcc cct agt ggc ggt ggc tgg att ggc ggc      240
 Thr Asp Arg Ser Ser Gly Ala Pro Ser Gly Gly Gly Trp Ile Gly Gly
  65                  70                  75                  80

 tgt ggg ttt gaa cga ccc ggt ggt cgt tgg ggc cct tgt aat aat tat      288
 Cys Gly Phe Glu Arg Pro Gly Gly Arg Trp Gly Pro Cys Asn Asn Tyr
                  85                  90                  95

 caa aca ctt act tta tgc cag tac tta gtg ctt tac aaa gat cat ctc      336
 Gln Thr Leu Thr Leu Cys Gln Tyr Leu Val Leu Tyr Lys Asp His Leu
             100                 105                 110

 act gaa gct cca caa aaa ccc ttt cag tat gga cct gta ttt agt ttt      384
 Thr Glu Ala Pro Gln Lys Pro Phe Gln Tyr Gly Pro Val Phe Ser Phe
         115                 120                 125

 acc atg gta ggc aag aca ttt act tac ctt ctg ggg agt gat gct gct      432
 Thr Met Val Gly Lys Thr Phe Thr Tyr Leu Leu Gly Ser Asp Ala Ala
     130                 135                 140

 gca ctg ctt ttt aat agt aaa aat gaa gac ctg aat gca gaa gat gtc      480
 Ala Leu Leu Phe Asn Ser Lys Asn Glu Asp Leu Asn Ala Glu Asp Val
 145                 150                 155                 160

 tac agt cgc ctg aca aca cct gtg ttt ggg aag gga gtt gca tac gat      528
 Tyr Ser Arg Leu Thr Thr Pro Val Phe Gly Lys Gly Val Ala Tyr Asp
                 165                 170                 175

 gtg cct aat cca gtt ttc ttg gag cag aag aaa atg tta aaa agt ggc      576
 Val Pro Asn Pro Val Phe Leu Glu Gln Lys Lys Met Leu Lys Ser Gly
             180                 185                 190

 ctt aac ata gcc cac ttt aaa cag cat gtt tct ata att gaa aaa gaa      624
 Leu Asn Ile Ala His Phe Lys Gln His Val Ser Ile Ile Glu Lys Glu
         195                 200                 205

 aca aag gaa tac ttt gag agt tgg gga gaa agt gga gaa aaa aat gtg      672
 Thr Lys Glu Tyr Phe Glu Ser Trp Gly Glu Ser Gly Glu Lys Asn Val
     210                 215                 220

 ttt gaa gct ctt tct gag ctc ata att tta aca gct agc cat tgt ttg      720
 Phe Glu Ala Leu Ser Glu Leu Ile Ile Leu Thr Ala Ser His Cys Leu
 225                 230                 235                 240

 cat gga aag gaa atc aga agt caa ctc aat gaa aag gta gca cag ctg      768
 His Gly Lys Glu Ile Arg Ser Gln Leu Asn Glu Lys Val Ala Gln Leu
                 245                 250                 255

 tat gca gat ttg gat gga ggt ttc agc cat gca gcc tgg ctc tta cca      816
 Tyr Ala Asp Leu Asp Gly Gly Phe Ser His Ala Ala Trp Leu Leu Pro
             260                 265                 270

 ggt tgg ctg cct ttg cct agt ttc aga cgc agg gac aga gct cat cgg      864
 Gly Trp Leu Pro Leu Pro Ser Phe Arg Arg Arg Asp Arg Ala His Arg
         275                 280                 285

 gaa atc aag gat att ttc tat aag gca atc cag aaa cgc aga cag tct      912
 Glu Ile Lys Asp Ile Phe Tyr Lys Ala Ile Gln Lys Arg Arg Gln Ser
     290                 295                 300

 caa gaa aaa att gat gac att ctc caa act tta cta gat gct aca tac      960
 Gln Glu Lys Ile Asp Asp Ile Leu Gln Thr Leu Leu Asp Ala Thr Tyr
 305                 310                 315                 320

 aag gat ggg cgt cct ttg act gat gat gaa gta gca ggg atg ctt att     1008
 Lys Asp Gly Arg Pro Leu Thr Asp Asp Glu Val Ala Gly Met Leu Ile
                 325                 330                 335

 gga tta ctc ttg gca ggg cag cat aca tcc tca act act agt gct tgg     1056
 Gly Leu Leu Leu Ala Gly Gln His Thr Ser Ser Thr Thr Ser Ala Trp
             340                 345                 350

 atg ggc ttc ttt ttg gcc aga gac aaa aca ctt caa aaa aaa tgt tat     1104
 Met Gly Phe Phe Leu Ala Arg Asp Lys Thr Leu Gln Lys Lys Cys Tyr
         355                 360                 365

 tta gaa cag aaa aca gtc tgt gga gag aat ctg cct cct tta act tat     1152
 Leu Glu Gln Lys Thr Val Cys Gly Glu Asn Leu Pro Pro Leu Thr Tyr
     370                 375                 380

 gac cag ctc aag gat cta aat tta ctt gat cgc tgt ata aaa gaa aca     1200
 Asp Gln Leu Lys Asp Leu Asn Leu Leu Asp Arg Cys Ile Lys Glu Thr
 385                 390                 395                 400

 tta aga ctt aga cct cct ata atg atc atg atg aga atg gcc aga act     1248
 Leu Arg Leu Arg Pro Pro Ile Met Ile Met Met Arg Met Ala Arg Thr
                 405                 410                 415

 cct cag act gtg gca ggg tat acc att cct cca gga cat cag gtg tgt     1296
 Pro Gln Thr Val Ala Gly Tyr Thr Ile Pro Pro Gly His Gln Val Cys
             420                 425                 430

 gtt tct ccc act gtc aat caa aga ctt aaa gac tca tgg gta gaa cgc     1344
 Val Ser Pro Thr Val Asn Gln Arg Leu Lys Asp Ser Trp Val Glu Arg
         435                 440                 445

 ctg gac ttt aat cct gat cgc tac tta cag gat aac cca gca tca ggg     1392
 Leu Asp Phe Asn Pro Asp Arg Tyr Leu Gln Asp Asn Pro Ala Ser Gly
     450                 455                 460

 gaa aag ttt gcc tat gtg cca ttt gga gct ggg cgt cat cgt tgt att     1440
 Glu Lys Phe Ala Tyr Val Pro Phe Gly Ala Gly Arg His Arg Cys Ile
 465                 470                 475                 480

 ggg gaa aat ttt gcc tat gtt caa att aag aca att tgg tcc act atg     1488
 Gly Glu Asn Phe Ala Tyr Val Gln Ile Lys Thr Ile Trp Ser Thr Met
                 485                 490                 495

 ctt cgt tta tat gaa ttt gat ctc att gat gga tac ttt ccc act gtg     1536
 Leu Arg Leu Tyr Glu Phe Asp Leu Ile Asp Gly Tyr Phe Pro Thr Val
             500                 505                 510

 aat tat aca act atg att cac acc cct gaa aac cca gtt atc cgt tac     1584
 Asn Tyr Thr Thr Met Ile His Thr Pro Glu Asn Pro Val Ile Arg Tyr
         515                 520                 525

 aaa cga aga tca aaa tga                                             1602
 Lys Arg Arg Ser Lys 
     530





      <210> 812
      <211> 1659
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (1)..(1659)

      <400> 812
  atg agg gag cac aaa gga ggg cat ttc ggc agc ttg ggg ttt ggg gtg      48
  Met Arg Glu His Lys Gly Gly His Phe Gly Ser Leu Gly Phe Gly Val
    1               5                  10                  15

 atc cac ttg gtg ttc acc aac ctg ctt ctg tgg gcc aac ggc gtc ctc       96
 Ile His Leu Val Phe Thr Asn Leu Leu Leu Trp Ala Asn Gly Val Leu
              20                  25                  30

 aat gag tca aag cac caa ctc aat gag cac aag gaa tgg ctc atc act      144
 Asn Glu Ser Lys His Gln Leu Asn Glu His Lys Glu Trp Leu Ile Thr
          35                  40                  45

 ctg ggc ttt ggg aac ata aca aca gtt tta gat gac cac aca ccg cag      192
 Leu Gly Phe Gly Asn Ile Thr Thr Val Leu Asp Asp His Thr Pro Gln
      50                  55                  60

 tgt aac tgc acg ccc cca act ctc tgc acc acc atc tcc cac ggg atc      240
 Cys Asn Cys Thr Pro Pro Thr Leu Cys Thr Thr Ile Ser His Gly Ile
  65                  70                  75                  80

 tac tat aac tac tac ctc tac ccc ttc aac ata gag tat cag atc ctg      288
 Tyr Tyr Asn Tyr Tyr Leu Tyr Pro Phe Asn Ile Glu Tyr Gln Ile Leu
                  85                  90                  95

 gcc tcc aca gtg ctc tac gtc cta tgg aag aac atc ggg cgc aaa gtt      336
 Ala Ser Thr Val Leu Tyr Val Leu Trp Lys Asn Ile Gly Arg Lys Val
             100                 105                 110

 gac agc cat cag cac cag aag atg cag ttc aag cct gat ggg gtc acg      384
 Asp Ser His Gln His Gln Lys Met Gln Phe Lys Pro Asp Gly Val Thr
         115                 120                 125

 gtg ggc aca gtc ctg ggc ctg acc gcg ctg gct gcc acc att gcc gtg      432
 Val Gly Thr Val Leu Gly Leu Thr Ala Leu Ala Ala Thr Ile Ala Val
     130                 135                 140

 gtg acc aag agc gag tca gca ctc atc acg ttc tac ctg tat gtc atc      480
 Val Thr Lys Ser Glu Ser Ala Leu Ile Thr Phe Tyr Leu Tyr Val Ile
 145                 150                 155                 160

 acc ctg atg atg ctt atg ggg gct gcg ggg ctg gct gga atc cgg att      528
 Thr Leu Met Met Leu Met Gly Ala Ala Gly Leu Ala Gly Ile Arg Ile
                 165                 170                 175

 tac agg aca gat gag aag tca ctg gat gag tcc aaa aat ccg ccc cgc      576
 Tyr Arg Thr Asp Glu Lys Ser Leu Asp Glu Ser Lys Asn Pro Pro Arg
             180                 185                 190

 aaa ctg gac tcg gac ctc ttg gtg ggc act gcc tca ggc tcc tgg ctt      624
 Lys Leu Asp Ser Asp Leu Leu Val Gly Thr Ala Ser Gly Ser Trp Leu
         195                 200                 205

 atc tcc tgg ggc tca atc ttg gcc atc ctt tgt gcc gag gac cac ccc      672
 Ile Ser Trp Gly Ser Ile Leu Ala Ile Leu Cys Ala Glu Asp His Pro
     210                 215                 220

 cac tac acc tgg tac aac ctg ccc tac tcc atc gtg gtg atc atg gag      720
 His Tyr Thr Trp Tyr Asn Leu Pro Tyr Ser Ile Val Val Ile Met Glu
 225                 230                 235                 240

 aag tac atc cag aac ctc ttc atc ttt gaa tcc att cac cga gag cct      768
 Lys Tyr Ile Gln Asn Leu Phe Ile Phe Glu Ser Ile His Arg Glu Pro
                 245                 250                 255

 aaa aaa ctc tct gag gac atc caa acc ctt cgg atg gtc aca gtc tgc      816
 Lys Lys Leu Ser Glu Asp Ile Gln Thr Leu Arg Met Val Thr Val Cys
             260                 265                 270

 aat ggc aac acc atg tcc ctt gct tcc tcc tgc ctc aag agt gga gtt      864
 Asn Gly Asn Thr Met Ser Leu Ala Ser Ser Cys Leu Lys Ser Gly Val
         275                 280                 285

 gtg gcc gga gac gtg gct ccc tgg ggc agg gac atg cca cca gca gcc      912
 Val Ala Gly Asp Val Ala Pro Trp Gly Arg Asp Met Pro Pro Ala Ala
     290                 295                 300

 aat gga aat gtg tgc ctg aga gaa agt tgt gac aag gag gag aag cag      960
 Asn Gly Asn Val Cys Leu Arg Glu Ser Cys Asp Lys Glu Glu Lys Gln
 305                 310                 315                 320

 gag gag agc agc tgg gga ggg aac cca agc cca gtc cac ctt cct cgt     1008
 Glu Glu Ser Ser Trp Gly Gly Asn Pro Ser Pro Val His Leu Pro Arg
                 325                 330                 335

 ttc tta cag ggc aac gcc aag aga aaa gtc ctg agg aat att gca gcc     1056
 Phe Leu Gln Gly Asn Ala Lys Arg Lys Val Leu Arg Asn Ile Ala Ala
             340                 345                 350

 ttc ttg ttc ctc tgc aat act ttg gtt caa ggg gta cgc atg cag att     1104
 Phe Leu Phe Leu Cys Asn Thr Leu Val Gln Gly Val Arg Met Gln Ile
         355                 360                 365

 tgt tac atg ggt aaa ttg cgt gtc gct gag gtt tgg tgc aca aat gat     1152
 Cys Tyr Met Gly Lys Leu Arg Val Ala Glu Val Trp Cys Thr Asn Asp
     370                 375                 380

 ccc gtc acc cag gtg gtg cca aag gca tct ggc aga gag caa gag ctg     1200
 Pro Val Thr Gln Val Val Pro Lys Ala Ser Gly Arg Glu Gln Glu Leu
 385                 390                 395                 400

 tct tct cca gca tcg gga gcc agt cca gag gcc cca gct gca ggt gct     1248
 Ser Ser Pro Ala Ser Gly Ala Ser Pro Glu Ala Pro Ala Ala Gly Ala
                 405                 410                 415

 gat gtg cat gtc cag gtg gag tgg gct cca ctc cag aga cgg aca tgg     1296
 Asp Val His Val Gln Val Glu Trp Ala Pro Leu Gln Arg Arg Thr Trp
             420                 425                 430

 aaa tgt gcc tct gtg gca tcc aaa tgg acg aac cca gta gac aga gaa     1344
 Lys Cys Ala Ser Val Ala Ser Lys Trp Thr Asn Pro Val Asp Arg Glu
         435                 440                 445

 gtg gaa aag gag ggt gtg gga aat agc tct tgg gct gcc att gta gat     1392
 Val Glu Lys Glu Gly Val Gly Asn Ser Ser Trp Ala Ala Ile Val Asp
     450                 455                 460

 cag atg gac cag ctt agc ggg aag gcc tcg ctg aag ggt gac atg aga     1440
 Gln Met Asp Gln Leu Ser Gly Lys Ala Ser Leu Lys Gly Asp Met Arg
 465                 470                 475                 480

 cag gaa ggg gtt ggc cac gca tgt tca ggg cag agg gaa caa cgg ctg     1488
 Gln Glu Gly Val Gly His Ala Cys Ser Gly Gln Arg Glu Gln Arg Leu
                 485                 490                 495

 ctt tgg ata cct ccc gct ttt ggc tgt cga cct gag tat gac aac gga     1536
 Leu Trp Ile Pro Pro Ala Phe Gly Cys Arg Pro Glu Tyr Asp Asn Gly
             500                 505                 510

 ttg gag gag att gtc ttt ggc ttt gaa ccc tgg ata att gtg gtc aac     1584
 Leu Glu Glu Ile Val Phe Gly Phe Glu Pro Trp Ile Ile Val Val Asn
         515                 520                 525

 ctg gcc atg cct ttt tct att ttc tat gga atg cac gca gct gcc tcc     1632
 Leu Ala Met Pro Phe Ser Ile Phe Tyr Gly Met His Ala Ala Ala Ser
     530                 535                 540

 ctc ttt gag gtc tat tgt aag ata tag                                 1659
 Leu Phe Glu Val Tyr Cys Lys Ile 
 545                 550





      <210> 813
      <211> 1809
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (1)..(1809)

      <400> 813
  atg aac agg atc cga aag ttt ttc cga gga agt ggg cga gtc ttg gca      48
  Met Asn Arg Ile Arg Lys Phe Phe Arg Gly Ser Gly Arg Val Leu Ala
    1               5                  10                  15

 ttt atc ttt gta gct tct gtc atc tgg ctc ctc ttt gac atg gca gct       96
 Phe Ile Phe Val Ala Ser Val Ile Trp Leu Leu Phe Asp Met Ala Ala
              20                  25                  30

 ctc cgc ctc tca ttc agt gag atc aac act cgg gtc atc aag gaa gac      144
 Leu Arg Leu Ser Phe Ser Glu Ile Asn Thr Arg Val Ile Lys Glu Asp
          35                  40                  45

 att gtg agg agg gag cgg ata gga ttc aga gtt cag cca gac caa gga      192
 Ile Val Arg Arg Glu Arg Ile Gly Phe Arg Val Gln Pro Asp Gln Gly
      50                  55                  60

 aaa att ttt tac agc agc ata aaa gag atg aaa cct ccc cta agg gga      240
 Lys Ile Phe Tyr Ser Ser Ile Lys Glu Met Lys Pro Pro Leu Arg Gly
  65                  70                  75                  80

 cat ggg aaa ggg gca tgg ggc aaa gag aat gtt aga aaa act gag gag      288
 His Gly Lys Gly Ala Trp Gly Lys Glu Asn Val Arg Lys Thr Glu Glu
                  85                  90                  95

 agt gtg ctc aag gtt gag gtg gac ttg gac caa acc cag agg gaa aga      336
 Ser Val Leu Lys Val Glu Val Asp Leu Asp Gln Thr Gln Arg Glu Arg
             100                 105                 110

 aaa atg cag aat gcc ctg gga agg ggc aag gtt gtg ccg ttg tgg cat      384
 Lys Met Gln Asn Ala Leu Gly Arg Gly Lys Val Val Pro Leu Trp His
         115                 120                 125

 cct gca cat ctg cag acc ctc cct gtg act cct aac aag cag aag aca      432
 Pro Ala His Leu Gln Thr Leu Pro Val Thr Pro Asn Lys Gln Lys Thr
     130                 135                 140

 gac ggg aga ggc acc aaa cct gaa gcc tcc tct cac cag ggg aca cca      480
 Asp Gly Arg Gly Thr Lys Pro Glu Ala Ser Ser His Gln Gly Thr Pro
 145                 150                 155                 160

 aag caa acg aca gct cag ggg gct cca aag acc tca ttc ata gca gca      528
 Lys Gln Thr Thr Ala Gln Gly Ala Pro Lys Thr Ser Phe Ile Ala Ala
                 165                 170                 175

 aaa gga act cag gta gtc aaa ata tca gta cac atg gga cgt gtc agt      576
 Lys Gly Thr Gln Val Val Lys Ile Ser Val His Met Gly Arg Val Ser
             180                 185                 190

 tta aaa cag gag ccc cgg aag agt cat agt ccc agc agt gac aca tca      624
 Leu Lys Gln Glu Pro Arg Lys Ser His Ser Pro Ser Ser Asp Thr Ser
         195                 200                 205

 aaa cta gca gct gaa agg gac ttg aat gtg acc atc agt ctt agt act      672
 Lys Leu Ala Ala Glu Arg Asp Leu Asn Val Thr Ile Ser Leu Ser Thr
     210                 215                 220

 gat aga cca aag cag cga tca cag gca gta gca aac gag agg gca cac      720
 Asp Arg Pro Lys Gln Arg Ser Gln Ala Val Ala Asn Glu Arg Ala His
 225                 230                 235                 240

 cct gcc agc aca gca gtg ccg aag tct ggg gaa gcc atg gcc tta aac      768
 Pro Ala Ser Thr Ala Val Pro Lys Ser Gly Glu Ala Met Ala Leu Asn
                 245                 250                 255

 aaa act aag act cag agc aaa gaa gtc aat gca aat aaa cac aaa gcc      816
 Lys Thr Lys Thr Gln Ser Lys Glu Val Asn Ala Asn Lys His Lys Ala
             260                 265                 270

 aat acg agt ctt cct ttt cct aag ttc act gtc aat tca aat cgc tta      864
 Asn Thr Ser Leu Pro Phe Pro Lys Phe Thr Val Asn Ser Asn Arg Leu
         275                 280                 285

 agg aag caa tct att aat gag aca cct ttg gga agt ttg tca aag gat      912
 Arg Lys Gln Ser Ile Asn Glu Thr Pro Leu Gly Ser Leu Ser Lys Asp
     290                 295                 300

 gat gga gct aga ggg gct cat ggg aag aaa ctc aat ttc tct gaa agc      960
 Asp Gly Ala Arg Gly Ala His Gly Lys Lys Leu Asn Phe Ser Glu Ser
 305                 310                 315                 320

 cat ctt gtg att ata acc aaa gag gaa gag caa aag gca gac ccc aaa     1008
 His Leu Val Ile Ile Thr Lys Glu Glu Glu Gln Lys Ala Asp Pro Lys
                 325                 330                 335

 gag gtc tct aat tct aaa acc aaa aca ata ttt cct aaa gta ttg ggt     1056
 Glu Val Ser Asn Ser Lys Thr Lys Thr Ile Phe Pro Lys Val Leu Gly
             340                 345                 350

 aaa agc caa agt aaa cac att tcc agg aat aga agt gag atg tct tcc     1104
 Lys Ser Gln Ser Lys His Ile Ser Arg Asn Arg Ser Glu Met Ser Ser
         355                 360                 365

 tct tca ctt gct cca cat aga gtg cca ctg tcc caa act aac cat gct     1152
 Ser Ser Leu Ala Pro His Arg Val Pro Leu Ser Gln Thr Asn His Ala
     370                 375                 380

 tta act gga ggg cta gag cca gca aaa atc aac ata act gcc aaa gcc     1200
 Leu Thr Gly Gly Leu Glu Pro Ala Lys Ile Asn Ile Thr Ala Lys Ala
 385                 390                 395                 400

 ccc tct aca gaa tac aac cag agt cat ata aaa gcc ctt tta cct gaa     1248
 Pro Ser Thr Glu Tyr Asn Gln Ser His Ile Lys Ala Leu Leu Pro Glu
                 405                 410                 415

 gac agt gga acg cac cag gtg tta aga att gat gtg aca ctt tct cca     1296
 Asp Ser Gly Thr His Gln Val Leu Arg Ile Asp Val Thr Leu Ser Pro
             420                 425                 430

 agg gac ccc aaa gct cca ggg cag ttt ggg cgt cct gta gtt gtc ccc     1344
 Arg Asp Pro Lys Ala Pro Gly Gln Phe Gly Arg Pro Val Val Val Pro
         435                 440                 445

 cat gga aag gag aag gag gca gaa aga aga tgg aaa gaa gga aac ttc     1392
 His Gly Lys Glu Lys Glu Ala Glu Arg Arg Trp Lys Glu Gly Asn Phe
     450                 455                 460

 aat gtc tac ctt agc gat ttg atc cca gtg gat aga gcc att gaa gac     1440
 Asn Val Tyr Leu Ser Asp Leu Ile Pro Val Asp Arg Ala Ile Glu Asp
 465                 470                 475                 480

 acc aga cct gct ggg gga ctt atg acc caa agg aaa gca ctt aca gcc     1488
 Thr Arg Pro Ala Gly Gly Leu Met Thr Gln Arg Lys Ala Leu Thr Ala
                 485                 490                 495

 cag act ctg tct caa aaa aaa aaa aaa tgt gaa agc gtt gtc aga gac     1536
 Gln Thr Leu Ser Gln Lys Lys Lys Lys Cys Glu Ser Val Val Arg Asp
             500                 505                 510

 ggc atc tct atg aag gga ata ttt aag ata gga act aaa gga ata gaa     1584
 Gly Ile Ser Met Lys Gly Ile Phe Lys Ile Gly Thr Lys Gly Ile Glu
         515                 520                 525

 gca gcc agc tgc gaa gac atg gga agg gta gca aaa atg cta gaa gtt     1632
 Ala Ala Ser Cys Glu Asp Met Gly Arg Val Ala Lys Met Leu Glu Val
     530                 535                 540

 aag caa ata aca aaa gct gga gtg ttc ttc agg gaa ctg aaa gaa ggc     1680
 Lys Gln Ile Thr Lys Ala Gly Val Phe Phe Arg Glu Leu Lys Glu Gly
 545                 550                 555                 560

 caa ggt gga aaa ttg act gag gat ttt aaa cag aag agt ggt gtt gat     1728
 Gln Gly Gly Lys Leu Thr Glu Asp Phe Lys Gln Lys Ser Gly Val Asp
                 565                 570                 575

 ctg aca aac tgt gga agt agt gtc cct tta gga gac tcc agc aat aat     1776
 Leu Thr Asn Cys Gly Ser Ser Val Pro Leu Gly Asp Ser Ser Asn Asn
             580                 585                 590

 cct gga gaa aga gag tgg atg ctc aag agc tag                         1809
 Pro Gly Glu Arg Glu Trp Met Leu Lys Ser 
         595                 600





      <210> 814
      <211> 1698
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (1)..(1698)

      <400> 814
  atg tgg ccc ctg gta gcg gcg ctg ttg ctg ggc tcg gcg tgc tgc gga      48
  Met Trp Pro Leu Val Ala Ala Leu Leu Leu Gly Ser Ala Cys Cys Gly
    1               5                  10                  15

 tca gct cag cta cta ttt aat aaa aca aaa tct gta gaa ttc acg ttt       96
 Ser Ala Gln Leu Leu Phe Asn Lys Thr Lys Ser Val Glu Phe Thr Phe
              20                  25                  30

 tgt aat gac act gtc gtc att cca tgc ttt gtt act aat atg gag gca      144
 Cys Asn Asp Thr Val Val Ile Pro Cys Phe Val Thr Asn Met Glu Ala
          35                  40                  45

 caa aac act act gaa gta tac gta aag tgg aaa ttt aaa gga aga gat      192
 Gln Asn Thr Thr Glu Val Tyr Val Lys Trp Lys Phe Lys Gly Arg Asp
      50                  55                  60

 att tac acc ttt gat gga gct cta aac aag tcc act gtc ccc act gac      240
 Ile Tyr Thr Phe Asp Gly Ala Leu Asn Lys Ser Thr Val Pro Thr Asp
  65                  70                  75                  80

 ttt agt agt gca aaa att gaa gtc tca caa tta cta aaa gga gat gcc      288
 Phe Ser Ser Ala Lys Ile Glu Val Ser Gln Leu Leu Lys Gly Asp Ala
                  85                  90                  95

 tct ttg aag atg gat aag agt gat gct gtc tca cac aca gga aac tac      336
 Ser Leu Lys Met Asp Lys Ser Asp Ala Val Ser His Thr Gly Asn Tyr
             100                 105                 110

 act tgt gaa gta aca gaa tta acc aga gaa ggt gaa acg atc atc gag      384
 Thr Cys Glu Val Thr Glu Leu Thr Arg Glu Gly Glu Thr Ile Ile Glu
         115                 120                 125

 cta aaa tat cgt gtt gtt tca tgg ttt tct cca aat gaa aat att ctt      432
 Leu Lys Tyr Arg Val Val Ser Trp Phe Ser Pro Asn Glu Asn Ile Leu
     130                 135                 140

 att gtt att ttc cca att ttt gct ata ctc ctg ttc tgg gga cag ttt      480
 Ile Val Ile Phe Pro Ile Phe Ala Ile Leu Leu Phe Trp Gly Gln Phe
 145                 150                 155                 160

 ggt att aaa aca ctt aaa tat aga tcc ggt ggt atg gat gag aaa aca      528
 Gly Ile Lys Thr Leu Lys Tyr Arg Ser Gly Gly Met Asp Glu Lys Thr
                 165                 170                 175

 att gct tta ctt gtt gct gga cta gtg atc act gtc att gtc att gtt      576
 Ile Ala Leu Leu Val Ala Gly Leu Val Ile Thr Val Ile Val Ile Val
             180                 185                 190

 gga gcc att ctt ttc gtc cca ggt gaa tat tca tta aag aat gct act      624
 Gly Ala Ile Leu Phe Val Pro Gly Glu Tyr Ser Leu Lys Asn Ala Thr
         195                 200                 205

 ggc ctt ggt tta att gtg act tct aca ggg ata tta ata tta ctt cac      672
 Gly Leu Gly Leu Ile Val Thr Ser Thr Gly Ile Leu Ile Leu Leu His
     210                 215                 220

 tac tat gtg ttt agt aca gcg att gga tta acc tcc ttc gtc att gcc      720
 Tyr Tyr Val Phe Ser Thr Ala Ile Gly Leu Thr Ser Phe Val Ile Ala
 225                 230                 235                 240

 ata ttg gtt att cag gtg ata gcc tat atc ctc gct gtg gtt gga ctg      768
 Ile Leu Val Ile Gln Val Ile Ala Tyr Ile Leu Ala Val Val Gly Leu
                 245                 250                 255

 agt ctc tgt att gcg gtg cag ttt ttg gtt cat ggc aaa att gag tgg      816
 Ser Leu Cys Ile Ala Val Gln Phe Leu Val His Gly Lys Ile Glu Trp
             260                 265                 270

 aaa gta cat tca cat gga tat ttt tat gtg gac ata agt ttt caa ttc      864
 Lys Val His Ser His Gly Tyr Phe Tyr Val Asp Ile Ser Phe Gln Phe
         275                 280                 285

 cat ttg ggc aaa tac caa gga gtg caa tta cgg gac tgt aaa gac gtg      912
 His Leu Gly Lys Tyr Gln Gly Val Gln Leu Arg Asp Cys Lys Asp Val
     290                 295                 300

 tat acc aat gca tgg ccc tct tct gat ttc agg ttt gag tat ctt agc      960
 Tyr Thr Asn Ala Trp Pro Ser Ser Asp Phe Arg Phe Glu Tyr Leu Ser
 305                 310                 315                 320

 tct agc aca att act tgg act agt tta tat gaa att tgt ggt tta gga     1008
 Ser Ser Thr Ile Thr Trp Thr Ser Leu Tyr Glu Ile Cys Gly Leu Gly
                 325                 330                 335

 cca aaa atg aga aaa tac aat tgg agt gat tcg agg ata att aaa gag     1056
 Pro Lys Met Arg Lys Tyr Asn Trp Ser Asp Ser Arg Ile Ile Lys Glu
             340                 345                 350

 ggt aga aga cat ata gga ttt tta gtt ggt tct tcc agt tta aga cca     1104
 Gly Arg Arg His Ile Gly Phe Leu Val Gly Ser Ser Ser Leu Arg Pro
         355                 360                 365

 gaa gtc aga aaa tac aat tgg aat gat ttg agg aat ggg cca gcc aac     1152
 Glu Val Arg Lys Tyr Asn Trp Asn Asp Leu Arg Asn Gly Pro Ala Asn
     370                 375                 380

 tgt gac atc cct tgg atc gga gat tta gaa cta gaa agt att ctt tct     1200
 Cys Asp Ile Pro Trp Ile Gly Asp Leu Glu Leu Glu Ser Ile Leu Ser
 385                 390                 395                 400

 aca tta tta ggg aag aaa agg agt tac ttg gcg ggt tta aag tgc cct     1248
 Thr Leu Leu Gly Lys Lys Arg Ser Tyr Leu Ala Gly Leu Lys Cys Pro
                 405                 410                 415

 gtt tgg gcc agg tgt ctt cac act gag aaa agc ggc gtt cca cgg tca     1296
 Val Trp Ala Arg Cys Leu His Thr Glu Lys Ser Gly Val Pro Arg Ser
             420                 425                 430

 cag cca ggg cga tat gaa gac ccc agg aag gaa att atg ctg aga aaa     1344
 Gln Pro Gly Arg Tyr Glu Asp Pro Arg Lys Glu Ile Met Leu Arg Lys
         435                 440                 445

 gga gat cac acc tct gtc cag cct gca ccg gcc cct tgg cat gcc ctg     1392
 Gly Asp His Thr Ser Val Gln Pro Ala Pro Ala Pro Trp His Ala Leu
     450                 455                 460

 aag aca caa ggc cta aat caa ggt caa aga cac agc cct cct ggt tgt     1440
 Lys Thr Gln Gly Leu Asn Gln Gly Gln Arg His Ser Pro Pro Gly Cys
 465                 470                 475                 480

 gaa gat tcc aaa ggc tcc cag ctg cat gag gag ggt tac cca gaa tgt     1488
 Glu Asp Ser Lys Gly Ser Gln Leu His Glu Glu Gly Tyr Pro Glu Cys
                 485                 490                 495

 cag att tgg agc aat tca gcg aga acc ctt caa aat tca gtg tgg tat     1536
 Gln Ile Trp Ser Asn Ser Ala Arg Thr Leu Gln Asn Ser Val Trp Tyr
             500                 505                 510

 gtg gaa gag ggt cac cct cat cta gca gat gtg ggc agg aag aga agt     1584
 Val Glu Glu Gly His Pro His Leu Ala Asp Val Gly Arg Lys Arg Ser
         515                 520                 525

 cca ctt gtg ctt gct gcc aga gga gat ggc cac tgc caa ttg agg ctg     1632
 Pro Leu Val Leu Ala Ala Arg Gly Asp Gly His Cys Gln Leu Arg Leu
     530                 535                 540

 atc atg aag agt ggg ttc ctg gag tcc tca gca gag cac tgg cta ttc     1680
 Ile Met Lys Ser Gly Phe Leu Glu Ser Ser Ala Glu His Trp Leu Phe
 545                 550                 555                 560

 atg gac aag gac agg tga                                             1698
 Met Asp Lys Asp Arg 
                 565





      <210> 815
      <211> 981
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (1)..(981)

      <400> 815
  atg gtg gtt gct gct cct ttt atc att tgg gtt ttt ctg gca gct gcg      48
  Met Val Val Ala Ala Pro Phe Ile Ile Trp Val Phe Leu Ala Ala Ala
    1               5                  10                  15

 acc aac gtg gac ccc gca gga gac agt gtg tcc tac agc atc cac agc       96
 Thr Asn Val Asp Pro Ala Gly Asp Ser Val Ser Tyr Ser Ile His Ser
              20                  25                  30

 aca gcc aag gtg gtg ctg acc cgc gag gac gtt cac tct caa gtc atc      144
 Thr Ala Lys Val Val Leu Thr Arg Glu Asp Val His Ser Gln Val Ile
          35                  40                  45

 tgc gag gtg gcc cac gtc acc ttg cag ggg gac cct ctt cgt ggg act      192
 Cys Glu Val Ala His Val Thr Leu Gln Gly Asp Pro Leu Arg Gly Thr
      50                  55                  60

 gcc aac ttg tct gag acc atc cga gtt cca ccc acc ttg gag gtt act      240
 Ala Asn Leu Ser Glu Thr Ile Arg Val Pro Pro Thr Leu Glu Val Thr
  65                  70                  75                  80

 caa cag ccc gtg agg gca gag aac cag gtg aat gtc acc tgc cag gtg      288
 Gln Gln Pro Val Arg Ala Glu Asn Gln Val Asn Val Thr Cys Gln Val
                  85                  90                  95

 agg aag ttc tac ccc cag aga cta cag ctg acc tgg ttg gag aat gga      336
 Arg Lys Phe Tyr Pro Gln Arg Leu Gln Leu Thr Trp Leu Glu Asn Gly
             100                 105                 110

 aac gtg tcc agg aca gaa acg gcc tca acc ctt aca gaa aac aag gat      384
 Asn Val Ser Arg Thr Glu Thr Ala Ser Thr Leu Thr Glu Asn Lys Asp
         115                 120                 125

 ggt acc tac aac tgg atg agc tgg ctc ctg gtg aat gta tct gcc cac      432
 Gly Thr Tyr Asn Trp Met Ser Trp Leu Leu Val Asn Val Ser Ala His
     130                 135                 140

 agg gat gat gtg aag ctc acc tgc cag gtg gag cat gac ggg cag cca      480
 Arg Asp Asp Val Lys Leu Thr Cys Gln Val Glu His Asp Gly Gln Pro
 145                 150                 155                 160

 gcg gtc agc aaa agc cat gac ctg aag gtc tca gcc cac ccg aag gag      528
 Ala Val Ser Lys Ser His Asp Leu Lys Val Ser Ala His Pro Lys Glu
                 165                 170                 175

 cag ggc tca aat act gct cct gga cat ctt cct gcc cac agg ctc ctg      576
 Gln Gly Ser Asn Thr Ala Pro Gly His Leu Pro Ala His Arg Leu Leu
             180                 185                 190

 ttg ctc ctt tgc aga gtc ctt gat tct cca gag cag tct tca ttc atg      624
 Leu Leu Leu Cys Arg Val Leu Asp Ser Pro Glu Gln Ser Ser Phe Met
         195                 200                 205

 gtc ctg agc aga ggc cat ggg atg ggg ctc tgg gga gtg act cat gac      672
 Val Leu Ser Arg Gly His Gly Met Gly Leu Trp Gly Val Thr His Asp
     210                 215                 220

 acc tcc cta gga tgt ggg aaa cac gcc aaa tct aaa cac atc agg aca      720
 Thr Ser Leu Gly Cys Gly Lys His Ala Lys Ser Lys His Ile Arg Thr
 225                 230                 235                 240

 cct ctc ctc cat cgt ctt gga ctc tcc gaa gca cta ctg aat att tct      768
 Pro Leu Leu His Arg Leu Gly Leu Ser Glu Ala Leu Leu Asn Ile Ser
                 245                 250                 255

 ctc ata ccc act atg agg acc aat caa gct gct gta ggt aaa att cac      816
 Leu Ile Pro Thr Met Arg Thr Asn Gln Ala Ala Val Gly Lys Ile His
             260                 265                 270

 aga aga ggg gca ggt tgg aaa gtc ttt gct ccc agc tcc cag ata ggc      864
 Arg Arg Gly Ala Gly Trp Lys Val Phe Ala Pro Ser Ser Gln Ile Gly
         275                 280                 285

 ttc ctg tcc tca ctc ctt act cag gcc atg gag ctg aca cca ggg tca      912
 Phe Leu Ser Ser Leu Leu Thr Gln Ala Met Glu Leu Thr Pro Gly Ser
     290                 295                 300

 cag cgc tgg gca cag cag cct ctc agc tcc cca ctg ggc cct gct gtg      960
 Gln Arg Trp Ala Gln Gln Pro Leu Ser Ser Pro Leu Gly Pro Ala Val
 305                 310                 315                 320

 atg cca cct cac aag tcc tag                                          981
 Met Pro Pro His Lys Ser 
                 325





      <210> 816
      <211> 924
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (1)..(924)

      <400> 816
  atg gac gtg gtg aat cag ctg gtg gct ggg ggt cag ttc cgg gtg gtc      48
  Met Asp Val Val Asn Gln Leu Val Ala Gly Gly Gln Phe Arg Val Val
    1               5                  10                  15

 aag gag ccc ctc ggc ttt gtg aag gtg ctg caa tgg gtc ttc gcc atc       96
 Lys Glu Pro Leu Gly Phe Val Lys Val Leu Gln Trp Val Phe Ala Ile
              20                  25                  30

 ttc gcc ttt gcc aca tgc ggc agc tac agt ggg gag ctc cag ctg agc      144
 Phe Ala Phe Ala Thr Cys Gly Ser Tyr Ser Gly Glu Leu Gln Leu Ser
          35                  40                  45

 gtg gat tgt gcc aac aag acc gag agt gac ctc agc atc gag gtc gag      192
 Val Asp Cys Ala Asn Lys Thr Glu Ser Asp Leu Ser Ile Glu Val Glu
      50                  55                  60

 ttc gag tac ccc ttc agg ctg cac caa gtg tac ttt gat gca ccc acc      240
 Phe Glu Tyr Pro Phe Arg Leu His Gln Val Tyr Phe Asp Ala Pro Thr
  65                  70                  75                  80

 tgc cga ggg ggc acc acc aag gtc ttc tta gtt ggg gac tac tcc tcg      288
 Cys Arg Gly Gly Thr Thr Lys Val Phe Leu Val Gly Asp Tyr Ser Ser
                  85                  90                  95

 tca gcc gaa ttc ttt gtc acc gtg gcc gtg ttt gcc ttc ctc tac tcc      336
 Ser Ala Glu Phe Phe Val Thr Val Ala Val Phe Ala Phe Leu Tyr Ser
             100                 105                 110

 atg ggg gct ctg gcc acc tac atc ttc ctg cag aac aag tac cga gag      384
 Met Gly Ala Leu Ala Thr Tyr Ile Phe Leu Gln Asn Lys Tyr Arg Glu
         115                 120                 125

 aat aac aaa ggg ccc atg ctg gac ttt ctg gcc acg gct gtg ttc gcc      432
 Asn Asn Lys Gly Pro Met Leu Asp Phe Leu Ala Thr Ala Val Phe Ala
     130                 135                 140

 ttc atg tgg cta gtt agc tca tcg gca tgg gcc aag ggg ctg tca gat      480
 Phe Met Trp Leu Val Ser Ser Ser Ala Trp Ala Lys Gly Leu Ser Asp
 145                 150                 155                 160

 gtg aag atg gcc aca gac cca gag aac att atc aag gag atg cct gtc      528
 Val Lys Met Ala Thr Asp Pro Glu Asn Ile Ile Lys Glu Met Pro Val
                 165                 170                 175

 tgc cgc cag aca ggg aac aca tgc aag gag ctg aga gac cct gtg acc      576
 Cys Arg Gln Thr Gly Asn Thr Cys Lys Glu Leu Arg Asp Pro Val Thr
             180                 185                 190

 tcg gga ctc aac acc tcg gtg gtg ttc ggc ttc ctg aac ctg gtg ctc      624
 Ser Gly Leu Asn Thr Ser Val Val Phe Gly Phe Leu Asn Leu Val Leu
         195                 200                 205

 tgg gtc ggc aac ctg tgg ttc gtg ttt aag gag aca ggc tgg gcc gcc      672
 Trp Val Gly Asn Leu Trp Phe Val Phe Lys Glu Thr Gly Trp Ala Ala
     210                 215                 220

 ccg ttc ctg cgc gcg cct ccc ggc gcc ccc gag aaa caa ccg gca ccc      720
 Pro Phe Leu Arg Ala Pro Pro Gly Ala Pro Glu Lys Gln Pro Ala Pro
 225                 230                 235                 240

 ggg gac gcc tac ggc gat gca ggc tac ggg cag ggc ccc ggc ggg tac      768
 Gly Asp Ala Tyr Gly Asp Ala Gly Tyr Gly Gln Gly Pro Gly Gly Tyr
                 245                 250                 255

 ggg ccc cag gat tcc tac ggg cct cag ggc ggc tac cag cct gac tat      816
 Gly Pro Gln Asp Ser Tyr Gly Pro Gln Gly Gly Tyr Gln Pro Asp Tyr
             260                 265                 270

 ggt caa cca gcc ggc agc ggt ggc agt ggc tac ggg cct cag ggc gac      864
 Gly Gln Pro Ala Gly Ser Gly Gly Ser Gly Tyr Gly Pro Gln Gly Asp
         275                 280                 285

 tat ggg cag caa ggc tac ggc ccg cag ggt gca ccc acc tcc ttc tcc      912
 Tyr Gly Gln Gln Gly Tyr Gly Pro Gln Gly Ala Pro Thr Ser Phe Ser
     290                 295                 300

 aat cag atg tag                                                      924
 Asn Gln Met 
 305





      <210> 817
      <211> 645
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (1)..(645)

      <400> 817
  atg gtg agt gac ctc cac aaa ctg agg gaa aat gtt tgg gct ttg gct      48
  Met Val Ser Asp Leu His Lys Leu Arg Glu Asn Val Trp Ala Leu Ala
    1               5                  10                  15

 ggg ctt ctt ctg agc agt agt gca gcc cta att cat tct tct ctt ttc       96
 Gly Leu Leu Leu Ser Ser Ser Ala Ala Leu Ile His Ser Ser Leu Phe
              20                  25                  30

 cac aca atg aca tcg aag gtg ttt tgg cct gct att cgt aac gac ccc      144
 His Thr Met Thr Ser Lys Val Phe Trp Pro Ala Ile Arg Asn Asp Pro
          35                  40                  45

 ttc aca cat gtt agc ctg cgg aaa gaa gct cta ctg agc aga ggc gat      192
 Phe Thr His Val Ser Leu Arg Lys Glu Ala Leu Leu Ser Arg Gly Asp
      50                  55                  60

 cag ctt tcc cca gtg gat gtg aag tca gaa gtt cct gtg ggc ctg gag      240
 Gln Leu Ser Pro Val Asp Val Lys Ser Glu Val Pro Val Gly Leu Glu
  65                  70                  75                  80

 ccc atc tca cct tta gac cta agg aca gac ctc agg atg atg atg ccc      288
 Pro Ile Ser Pro Leu Asp Leu Arg Thr Asp Leu Arg Met Met Met Pro
                  85                  90                  95

 gtg gtg gac cct gtt gtc cgt gag aag caa ttg cag cag gaa tta ctt      336
 Val Val Asp Pro Val Val Arg Glu Lys Gln Leu Gln Gln Glu Leu Leu
             100                 105                 110

 ctt atc cag cag cag caa caa atc cag aag cag ctt ctg ata gca gag      384
 Leu Ile Gln Gln Gln Gln Gln Ile Gln Lys Gln Leu Leu Ile Ala Glu
         115                 120                 125

 ttt cag aaa cag cat gag aac ttg aca cgg cag cac cag gct cag ctt      432
 Phe Gln Lys Gln His Glu Asn Leu Thr Arg Gln His Gln Ala Gln Leu
     130                 135                 140

 cag gag cat atc aag ttg caa cag gaa ctt cta gcc ata aaa cag caa      480
 Gln Glu His Ile Lys Leu Gln Gln Glu Leu Leu Ala Ile Lys Gln Gln
 145                 150                 155                 160

 caa gaa ctc cta gaa aag gag cag aaa ctg gag cag cag agg caa gaa      528
 Gln Glu Leu Leu Glu Lys Glu Gln Lys Leu Glu Gln Gln Arg Gln Glu
                 165                 170                 175

 cag gaa gta gag agg cat cgc aga gaa cag cag ctt cct cct ctc aga      576
 Gln Glu Val Glu Arg His Arg Arg Glu Gln Gln Leu Pro Pro Leu Arg
             180                 185                 190

 ggc aaa gat aga gga cga gaa agt aag agg cac cag ggt aaa cga tgg      624
 Gly Lys Asp Arg Gly Arg Glu Ser Lys Arg His Gln Gly Lys Arg Trp
         195                 200                 205

 act ctc ttt cct cat cgt tag                                          645
 Thr Leu Phe Pro His Arg 
     210





      <210> 818
      <211> 2340
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (1)..(2340)

      <400> 818
  atg agc gaa gcc ggc ggc cgg ggc tgt ggg tcc ccg gtt ccc cag cga      48
  Met Ser Glu Ala Gly Gly Arg Gly Cys Gly Ser Pro Val Pro Gln Arg
    1               5                  10                  15

 gcg cga tgg aga cta gtg gcg gcg acg gcc gcg ttc tgc ctg gtg tcg       96
 Ala Arg Trp Arg Leu Val Ala Ala Thr Ala Ala Phe Cys Leu Val Ser
              20                  25                  30

 gcc acc tcc gtg tgg acg gcg ggg gcc gag ccc atg agt agg gag gag      144
 Ala Thr Ser Val Trp Thr Ala Gly Ala Glu Pro Met Ser Arg Glu Glu
          35                  40                  45

 aaa cag aag ctt ggg aaa gca gtg gtg ttt tcc aaa gac aag caa tat      192
 Lys Gln Lys Leu Gly Lys Ala Val Val Phe Ser Lys Asp Lys Gln Tyr
      50                  55                  60

 agt att att aag agc aag aac tct gga ctt gga gca gga cac cct gag      240
 Ser Ile Ile Lys Ser Lys Asn Ser Gly Leu Gly Ala Gly His Pro Glu
  65                  70                  75                  80

 atg gct ctg cca cct ctc atc tgg gtt aca atg gga aag tta cct agt      288
 Met Ala Leu Pro Pro Leu Ile Trp Val Thr Met Gly Lys Leu Pro Ser
                  85                  90                  95

 ctt cct gag cct gtt tct tca tct ctg caa aat gaa gac aat gat gaa      336
 Leu Pro Glu Pro Val Ser Ser Ser Leu Gln Asn Glu Asp Asn Asp Glu
             100                 105                 110

 gga aca agc tca gaa atg gaa gtt tta aat aaa act aaa gaa ttt gaa      384
 Gly Thr Ser Ser Glu Met Glu Val Leu Asn Lys Thr Lys Glu Phe Glu
         115                 120                 125

 gat gca gtg aga aaa gtt tta aga gat gtt aat tta gat aac gat gta      432
 Asp Ala Val Arg Lys Val Leu Arg Asp Val Asn Leu Asp Asn Asp Val
     130                 135                 140

 gtc gta tca gtc ttt gaa aca aac atc aga gtt ctt gga tta gat tat      480
 Val Val Ser Val Phe Glu Thr Asn Ile Arg Val Leu Gly Leu Asp Tyr
 145                 150                 155                 160

 gct gca gaa gga aga aca gat gct aga cca gaa ctt ggg cac aga att      528
 Ala Ala Glu Gly Arg Thr Asp Ala Arg Pro Glu Leu Gly His Arg Ile
                 165                 170                 175

 att tgt gta gaa gat ata att gaa gca gaa tat gcc aga aaa gct ctt      576
 Ile Cys Val Glu Asp Ile Ile Glu Ala Glu Tyr Ala Arg Lys Ala Leu
             180                 185                 190

 gat ttt ctc tgg gaa aaa aga cag cga agt agt aat tta gtg ggc gtg      624
 Asp Phe Leu Trp Glu Lys Arg Gln Arg Ser Ser Asn Leu Val Gly Val
         195                 200                 205

 act ata aat att cat act gga gat tgg gta cga aaa gat agt gga gtt      672
 Thr Ile Asn Ile His Thr Gly Asp Trp Val Arg Lys Asp Ser Gly Val
     210                 215                 220

 gga gca ggg att gat tca tat tat gaa tat ctg ttg aaa gcc tat gtc      720
 Gly Ala Gly Ile Asp Ser Tyr Tyr Glu Tyr Leu Leu Lys Ala Tyr Val
 225                 230                 235                 240

 ttg ctt gga gat gac agt ttt ctg gaa aga ttt aac aca gtg tta aag      768
 Leu Leu Gly Asp Asp Ser Phe Leu Glu Arg Phe Asn Thr Val Leu Lys
                 245                 250                 255

 ggg gat att aga cct gct att gaa act cat gaa atg tta tat cag gtg      816
 Gly Asp Ile Arg Pro Ala Ile Glu Thr His Glu Met Leu Tyr Gln Val
             260                 265                 270

 att aaa aaa cac aat ttt cta cca gag gct aca gga gat cct tac tac      864
 Ile Lys Lys His Asn Phe Leu Pro Glu Ala Thr Gly Asp Pro Tyr Tyr
         275                 280                 285

 ctt gaa gta ggg aag aca ctt att gaa aat tta aat aaa tat gct aga      912
 Leu Glu Val Gly Lys Thr Leu Ile Glu Asn Leu Asn Lys Tyr Ala Arg
     290                 295                 300

 gtg cct tgc gga ttt gct gcc atg aag gat gtt cgt act gga agt cat      960
 Val Pro Cys Gly Phe Ala Ala Met Lys Asp Val Arg Thr Gly Ser His
 305                 310                 315                 320

 gag gac aga atg gat tct ttc ttc ttg gct gaa atg ttt aaa tat ctt     1008
 Glu Asp Arg Met Asp Ser Phe Phe Leu Ala Glu Met Phe Lys Tyr Leu
                 325                 330                 335

 tac ctg tta ttt gct gat aaa gaa gac att att ttt gac ata gaa gat     1056
 Tyr Leu Leu Phe Ala Asp Lys Glu Asp Ile Ile Phe Asp Ile Glu Asp
             340                 345                 350

 tac atc ttt aca aca gaa gct cat ctg tta cct ctt tgg ctc tct act     1104
 Tyr Ile Phe Thr Thr Glu Ala His Leu Leu Pro Leu Trp Leu Ser Thr
         355                 360                 365

 aca aat caa agc atc tct aaa aag aac aca acc tcg gaa tat aca gaa     1152
 Thr Asn Gln Ser Ile Ser Lys Lys Asn Thr Thr Ser Glu Tyr Thr Glu
     370                 375                 380

 ctg gat gac agt aac ttc gat tgg act tgt cca aat act cag atc ctc     1200
 Leu Asp Asp Ser Asn Phe Asp Trp Thr Cys Pro Asn Thr Gln Ile Leu
 385                 390                 395                 400

 ttt cct aat gac cca ttg tat gct caa agt att cgt gag ccc ttg aaa     1248
 Phe Pro Asn Asp Pro Leu Tyr Ala Gln Ser Ile Arg Glu Pro Leu Lys
                 405                 410                 415

 aat gtg gtg gat aag agc tgt cct aga ggc atc atc aga gta gag gag     1296
 Asn Val Val Asp Lys Ser Cys Pro Arg Gly Ile Ile Arg Val Glu Glu
             420                 425                 430

 agt ttc agg agt gga gct aaa ccc cct ctg aga gcc aga gat ttc atg     1344
 Ser Phe Arg Ser Gly Ala Lys Pro Pro Leu Arg Ala Arg Asp Phe Met
         435                 440                 445

 gcc act aac cct gag cat tta gaa atc ctg aag aag atg ggg gct gct     1392
 Ala Thr Asn Pro Glu His Leu Glu Ile Leu Lys Lys Met Gly Ala Ala
     450                 455                 460

 agt tca atc gac gct gaa gat ggg ttg agg ttc atg cag gag atg att     1440
 Ser Ser Ile Asp Ala Glu Asp Gly Leu Arg Phe Met Gln Glu Met Ile
 465                 470                 475                 480

 gaa ttg tca agt cag caa caa aaa gaa cag cag ctg cct cca cga gct     1488
 Glu Leu Ser Ser Gln Gln Gln Lys Glu Gln Gln Leu Pro Pro Arg Ala
                 485                 490                 495

 gta caa att gtt tcc cac cca ttt ttt ggc agg gta gta ttg act gct     1536
 Val Gln Ile Val Ser His Pro Phe Phe Gly Arg Val Val Leu Thr Ala
             500                 505                 510

 gga cca gct cag ttt ggg ctg gat ctg tct aaa cat aaa gag aca aga     1584
 Gly Pro Ala Gln Phe Gly Leu Asp Leu Ser Lys His Lys Glu Thr Arg
         515                 520                 525

 gga ttt gtt gca agc agt aaa cca tcc aat ggt tgt tca gag ctt act     1632
 Gly Phe Val Ala Ser Ser Lys Pro Ser Asn Gly Cys Ser Glu Leu Thr
     530                 535                 540

 aac cca gag gca gtg atg gga aaa atc gca ctg ata caa aga gga cag     1680
 Asn Pro Glu Ala Val Met Gly Lys Ile Ala Leu Ile Gln Arg Gly Gln
 545                 550                 555                 560

 tgc atg ttt gca gaa aag gca cgc aac atc cag aat gct gga gcc att     1728
 Cys Met Phe Ala Glu Lys Ala Arg Asn Ile Gln Asn Ala Gly Ala Ile
                 565                 570                 575

 ggt ggc att gtt att gat gac aat gag ggg agc agc agt gat act gcc     1776
 Gly Gly Ile Val Ile Asp Asp Asn Glu Gly Ser Ser Ser Asp Thr Ala
             580                 585                 590

 cct ctg ttc cag atg gca ggt gat gga aag gat aca gat gac atc aag     1824
 Pro Leu Phe Gln Met Ala Gly Asp Gly Lys Asp Thr Asp Asp Ile Lys
         595                 600                 605

 atc ccc atg ctg ttc tta ttc agc aaa gaa gga agt atc ata ctg gat     1872
 Ile Pro Met Leu Phe Leu Phe Ser Lys Glu Gly Ser Ile Ile Leu Asp
     610                 615                 620

 gcc atc cgg gaa tat gag gag gta gaa gtg ctc ctc tct gat aaa gca     1920
 Ala Ile Arg Glu Tyr Glu Glu Val Glu Val Leu Leu Ser Asp Lys Ala
 625                 630                 635                 640

 aaa gat cga gat cct gaa atg gaa aat gaa gaa caa cca tcc tct gaa     1968
 Lys Asp Arg Asp Pro Glu Met Glu Asn Glu Glu Gln Pro Ser Ser Glu
                 645                 650                 655

 aat gat tct cag aat cag agt ggt gaa cag att tca tca agt tct cag     2016
 Asn Asp Ser Gln Asn Gln Ser Gly Glu Gln Ile Ser Ser Ser Ser Gln
             660                 665                 670

 gag gtt gat ttg gtt gat caa gag tct tct gag gaa aat tct cta aat     2064
 Glu Val Asp Leu Val Asp Gln Glu Ser Ser Glu Glu Asn Ser Leu Asn
         675                 680                 685

 tct cac cca gaa tca tta tct cta gca gat atg gac aat gct gca agc     2112
 Ser His Pro Glu Ser Leu Ser Leu Ala Asp Met Asp Asn Ala Ala Ser
     690                 695                 700

 att tcc cct tct gaa cag act tct aat ccc aca gaa aac cat gag act     2160
 Ile Ser Pro Ser Glu Gln Thr Ser Asn Pro Thr Glu Asn His Glu Thr
 705                 710                 715                 720

 aca aat ctt aat ggt gaa tgt aca gat tta gat aac cag ctt caa gaa     2208
 Thr Asn Leu Asn Gly Glu Cys Thr Asp Leu Asp Asn Gln Leu Gln Glu
                 725                 730                 735

 caa tca gaa act gag gaa gat tcc aat cct aat gtt agc tgg ggt aaa     2256
 Gln Ser Glu Thr Glu Glu Asp Ser Asn Pro Asn Val Ser Trp Gly Lys
             740                 745                 750

 aag gtc cag cct ata gac tcc ata tta gca gac tgg aat gaa gat ata     2304
 Lys Val Gln Pro Ile Asp Ser Ile Leu Ala Asp Trp Asn Glu Asp Ile
         755                 760                 765

 gaa gca ttt gaa atg atg gag aag gat gag cta tga                     2340
 Glu Ala Phe Glu Met Met Glu Lys Asp Glu Leu 
     770                 775





      <210> 819
      <211> 2745
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (1)..(2745)

      <400> 819
  atg gtg cag cca ctt tgg aaa gca gtc tgg cag ttc ctc aaa aag cta      48
  Met Val Gln Pro Leu Trp Lys Ala Val Trp Gln Phe Leu Lys Lys Leu
    1               5                  10                  15

 atc aca gag gtg ttt agt agc aag aaa aga aac tgt gct tgg gga gcc       96
 Ile Thr Glu Val Phe Ser Ser Lys Lys Arg Asn Cys Ala Trp Gly Ala
              20                  25                  30

 tac gct ttc cct ttg gcc ttg ttt atc cca gat att gag cag gcc agg      144
 Tyr Ala Phe Pro Leu Ala Leu Phe Ile Pro Asp Ile Glu Gln Ala Arg
          35                  40                  45

 gtg caa cac agc gtg acc gtg cct gtg ctc agc ctc cct tcc ctc caa      192
 Val Gln His Ser Val Thr Val Pro Val Leu Ser Leu Pro Ser Leu Gln
      50                  55                  60

 ccg ttc cct tcc ctt ccc tcc aac agt tcc ctt ccc ttc cct cca acc      240
 Pro Phe Pro Ser Leu Pro Ser Asn Ser Ser Leu Pro Phe Pro Pro Thr
  65                  70                  75                  80

 gtt ccc ttc cct tcc ctc caa ccg ttc cct tcc tcc aac cgt tgc ctg      288
 Val Pro Phe Pro Ser Leu Gln Pro Phe Pro Ser Ser Asn Arg Cys Leu
                  85                  90                  95

 cct gat gag gat agg act gac act gaa atc ctg ggt ggt gct gtt gaa      336
 Pro Asp Glu Asp Arg Thr Asp Thr Glu Ile Leu Gly Gly Ala Val Glu
             100                 105                 110

 tcg tgg ggc ttc ctg gtg tgg gat tgt ccc cgg cga acc tac tct ttc      384
 Ser Trp Gly Phe Leu Val Trp Asp Cys Pro Arg Arg Thr Tyr Ser Phe
         115                 120                 125

 cct ttg gcc tcg ttt att ccg gaa gtt ggt atg gac ccc tct tgg cat      432
 Pro Leu Ala Ser Phe Ile Pro Glu Val Gly Met Asp Pro Ser Trp His
     130                 135                 140

 ggg cag ttc tac cat ctg ctc acg cta agg gtt aag agc ttg cag cag      480
 Gly Gln Phe Tyr His Leu Leu Thr Leu Arg Val Lys Ser Leu Gln Gln
 145                 150                 155                 160

 gga agc cca gag ccc cca gag ccc agt gaa tgg cgg gga gag aac cgc      528
 Gly Ser Pro Glu Pro Pro Glu Pro Ser Glu Trp Arg Gly Glu Asn Arg
                 165                 170                 175

 tgg cgg cag acg agt gag ctg gga agc acc gaa gct gca gct gct gct      576
 Trp Arg Gln Thr Ser Glu Leu Gly Ser Thr Glu Ala Ala Ala Ala Ala
             180                 185                 190

 cag gtt cag gtg tca ggg ctg gga gaa tgt gtg act ggc ccc att tcg      624
 Gln Val Gln Val Ser Gly Leu Gly Glu Cys Val Thr Gly Pro Ile Ser
         195                 200                 205

 aat cct gag gaa gga cag gag agc ccc gat tac tcc gtg cta gga agg      672
 Asn Pro Glu Glu Gly Gln Glu Ser Pro Asp Tyr Ser Val Leu Gly Arg
     210                 215                 220

 acc caa gga agc ctg tgt tcc agt ccc ttc gac ctc gca gat gat aag      720
 Thr Gln Gly Ser Leu Cys Ser Ser Pro Phe Asp Leu Ala Asp Asp Lys
 225                 230                 235                 240

 aaa agg cgt cca gtg ctc ccg gcc cgg att gct cac tca tta aag cag      768
 Lys Arg Arg Pro Val Leu Pro Ala Arg Ile Ala His Ser Leu Lys Gln
                 245                 250                 255

 ggc tgg aat gtg gtc aag gtg cct ttg cct gga agc tcc gac ccc agg      816
 Gly Trp Asn Val Val Lys Val Pro Leu Pro Gly Ser Ser Asp Pro Arg
             260                 265                 270

 agc cag ccc atc aac ctg aac cat tac gcc acc aag aag agc gtg gcg      864
 Ser Gln Pro Ile Asn Leu Asn His Tyr Ala Thr Lys Lys Ser Val Ala
         275                 280                 285

 gag agc atg ctg gac gtg gcc ctg ttc atg tcc aac gcc atg cgg ctg      912
 Glu Ser Met Leu Asp Val Ala Leu Phe Met Ser Asn Ala Met Arg Leu
     290                 295                 300

 aag gcg gtg ctg gag cag gga cca tcc tct cac tac tac acc acc ctg      960
 Lys Ala Val Leu Glu Gln Gly Pro Ser Ser His Tyr Tyr Thr Thr Leu
 305                 310                 315                 320

 gtc acc ctc atc agc ctc tct ctg ctc ctg cag gtg gtc atc ggt gtc     1008
 Val Thr Leu Ile Ser Leu Ser Leu Leu Leu Gln Val Val Ile Gly Val
                 325                 330                 335

 ctg ctc gtg gtc att gtg ctt ccg aat ggc atc gat gac tcc agc tgg     1056
 Leu Leu Val Val Ile Val Leu Pro Asn Gly Ile Asp Asp Ser Ser Trp
             340                 345                 350

 gaa gtg gat gtg gag gtc aca gag gaa gat gat gct gtg cgg gtc ctg     1104
 Glu Val Asp Val Glu Val Thr Glu Glu Asp Asp Ala Val Arg Val Leu
         355                 360                 365

 ggg aca gat gtg ggc agg ctt gga cct ctt cag tgc cat ctc aac atc     1152
 Gly Thr Asp Val Gly Arg Leu Gly Pro Leu Gln Cys His Leu Asn Ile
     370                 375                 380

 cat gtc ctc act gct ata gtc agt gat gac gat gtt gaa gtg tgg gtc     1200
 His Val Leu Thr Ala Ile Val Ser Asp Asp Asp Val Glu Val Trp Val
 385                 390                 395                 400

 acc ggt gac ctg gaa cag gtt ttc cat gtc ttt gat gaa ttg ctg tac     1248
 Thr Gly Asp Leu Glu Gln Val Phe His Val Phe Asp Glu Leu Leu Tyr
                 405                 410                 415

 cca gcg tgc ctg gtt ctt cac tac ccc agg ggg tca ggc agg aga agg     1296
 Pro Ala Cys Leu Val Leu His Tyr Pro Arg Gly Ser Gly Arg Arg Arg
             420                 425                 430

 aaa cac aga caa ggc aaa gat gag cgg atg agc gcc tcc acc ccc agc     1344
 Lys His Arg Gln Gly Lys Asp Glu Arg Met Ser Ala Ser Thr Pro Ser
         435                 440                 445

 tcc cag tcc ctg gcc cca gga gag ccc ttt acc tta ccc ccg gct cct     1392
 Ser Gln Ser Leu Ala Pro Gly Glu Pro Phe Thr Leu Pro Pro Ala Pro
     450                 455                 460

 ctg gtt gag ctt ctt caa gaa gac tcg cgt gac ctc cag agc ttc ctg     1440
 Leu Val Glu Leu Leu Gln Glu Asp Ser Arg Asp Leu Gln Ser Phe Leu
 465                 470                 475                 480

 ctc tgg aag cag cag gtt gcc aga tgt gtt aca gct cag atc gat cca     1488
 Leu Trp Lys Gln Gln Val Ala Arg Cys Val Thr Ala Gln Ile Asp Pro
                 485                 490                 495

 gtc agt cct cag ggc ttg gaa gtc gag att ccg ggc act gaa ggt ctg     1536
 Val Ser Pro Gln Gly Leu Glu Val Glu Ile Pro Gly Thr Glu Gly Leu
             500                 505                 510

 gtc cca gtt tac tac cgg gtc aaa cac agt cta gag gtg tgg aag aga     1584
 Val Pro Val Tyr Tyr Arg Val Lys His Ser Leu Glu Val Trp Lys Arg
         515                 520                 525

 gaa gag gag gga gga aca gag aaa aca gga agc acg cga ggc ggt gag     1632
 Glu Glu Glu Gly Gly Thr Glu Lys Thr Gly Ser Thr Arg Gly Gly Glu
     530                 535                 540

 tgc gag acc agg aag gag aac caa gaa gtg aga gaa aaa ggg agg aag     1680
 Cys Glu Thr Arg Lys Glu Asn Gln Glu Val Arg Glu Lys Gly Arg Lys
 545                 550                 555                 560

 acg ggc gga atg aag gtt cct cct gag ctg ctg gat aga gct gcc aca     1728
 Thr Gly Gly Met Lys Val Pro Pro Glu Leu Leu Asp Arg Ala Ala Thr
                 565                 570                 575

 cca gtc ttc aaa cac atg cag gtt ggc acg gcc ccg gaa ctg cag ggc     1776
 Pro Val Phe Lys His Met Gln Val Gly Thr Ala Pro Glu Leu Gln Gly
             580                 585                 590

 gga gac gcc agt gag cct cag ctc cag gag gat gag cat ccc aca ccc     1824
 Gly Asp Ala Ser Glu Pro Gln Leu Gln Glu Asp Glu His Pro Thr Pro
         595                 600                 605

 gcc cca gat cct cag ctc cag gag gat gag cac ccc atg ccc gtc cca     1872
 Ala Pro Asp Pro Gln Leu Gln Glu Asp Glu His Pro Met Pro Val Pro
     610                 615                 620

 gct cct cag ctc cag gaa gat gag cac ccc atg ccc gcc cca gct cct     1920
 Ala Pro Gln Leu Gln Glu Asp Glu His Pro Met Pro Ala Pro Ala Pro
 625                 630                 635                 640

 cag ctc tgg gaa gat gag cac ccc atg ccc gcc cca gct cct cag ctc     1968
 Gln Leu Trp Glu Asp Glu His Pro Met Pro Ala Pro Ala Pro Gln Leu
                 645                 650                 655

 cgg gaa gat gag cac ccc atg ccc gcc cca gct cct cag ctc cag gag     2016
 Arg Glu Asp Glu His Pro Met Pro Ala Pro Ala Pro Gln Leu Gln Glu
             660                 665                 670

 gat gag cat ccc aca ccc gcc cca gat cct cag ttc cag gag gat gag     2064
 Asp Glu His Pro Thr Pro Ala Pro Asp Pro Gln Phe Gln Glu Asp Glu
         675                 680                 685

 cac ccc atg ccc gtc cca gct cct cag ctc cag gaa gat gag cac ccc     2112
 His Pro Met Pro Val Pro Ala Pro Gln Leu Gln Glu Asp Glu His Pro
     690                 695                 700

 atg ccc gcc cca gct cct cag ctc cgg gaa gat gag cac ccc atg ccc     2160
 Met Pro Ala Pro Ala Pro Gln Leu Arg Glu Asp Glu His Pro Met Pro
 705                 710                 715                 720

 gcc cca gct cct cag ctc cag gag gat gag cac ccc atg ccc atc cca     2208
 Ala Pro Ala Pro Gln Leu Gln Glu Asp Glu His Pro Met Pro Ile Pro
                 725                 730                 735

 gct cct cag ttc cag gag gat gag cac ccc atg ccc gtc cca gct cct     2256
 Ala Pro Gln Phe Gln Glu Asp Glu His Pro Met Pro Val Pro Ala Pro
             740                 745                 750

 cag ttc cag gag gat gag cac ccc atg ccc gtc cca gct cct cag ctc     2304
 Gln Phe Gln Glu Asp Glu His Pro Met Pro Val Pro Ala Pro Gln Leu
         755                 760                 765

 cag gaa gat gag cac ccc atg ccc gcc cca gct cct cag ctc cgg gaa     2352
 Gln Glu Asp Glu His Pro Met Pro Ala Pro Ala Pro Gln Leu Arg Glu
     770                 775                 780

 gat gag cac ccc atg ccc gcc cca gct cct cag ctc cag gag gat gag     2400
 Asp Glu His Pro Met Pro Ala Pro Ala Pro Gln Leu Gln Glu Asp Glu
 785                 790                 795                 800

 cac ccc atg cct gcc cca gct cct cag ctc cgg gag cgt gac cac ccc     2448
 His Pro Met Pro Ala Pro Ala Pro Gln Leu Arg Glu Arg Asp His Pro
                 805                 810                 815

 atg ccc atc cca gct cct cag ctc cgg gag gct ggg cag aaa ggg gcc     2496
 Met Pro Ile Pro Ala Pro Gln Leu Arg Glu Ala Gly Gln Lys Gly Ala
             820                 825                 830

 ggt gct cct ctc act gtg cgg gtc cgg ccc act cta tcc cat tcc cag     2544
 Gly Ala Pro Leu Thr Val Arg Val Arg Pro Thr Leu Ser His Ser Gln
         835                 840                 845

 ccc agc acc cag cac ttc ttt cag gaa cct ggt gct gat gtt cac ccc     2592
 Pro Ser Thr Gln His Phe Phe Gln Glu Pro Gly Ala Asp Val His Pro
     850                 855                 860

 atg gcc tgg cct tgg gga caa ggt ctg ctc tgg cca tgc aca cac aca     2640
 Met Ala Trp Pro Trp Gly Gln Gly Leu Leu Trp Pro Cys Thr His Thr
 865                 870                 875                 880

 cac ata ctc tcc ctg gac ctc cca tgc agg aag ggg gct ggt gtt cat     2688
 His Ile Leu Ser Leu Asp Leu Pro Cys Arg Lys Gly Ala Gly Val His
                 885                 890                 895

 tcc cca ggc aac ggg gac aat ggt tgt gac aga ata gct gag agg aca     2736
 Ser Pro Gly Asn Gly Asp Asn Gly Cys Asp Arg Ile Ala Glu Arg Thr
             900                 905                 910

 ggg aac tag                                                         2745
 Gly Asn 






      <210> 820
      <211> 1236
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (1)..(1236)

      <400> 820
  atg ggg acc tgt gac att gtg act gaa gcc aat atc tca tct ggc cct      48
  Met Gly Thr Cys Asp Ile Val Thr Glu Ala Asn Ile Ser Ser Gly Pro
    1               5                  10                  15

 gag agc aac acc acg ggc atc aca gcc ttc tcc atg ccc agc tgg caa       96
 Glu Ser Asn Thr Thr Gly Ile Thr Ala Phe Ser Met Pro Ser Trp Gln
              20                  25                  30

 ctg gca ctg tgg gcc aca gcc tac ctg gcc ctg gtg ctg gtg gcc gtg      144
 Leu Ala Leu Trp Ala Thr Ala Tyr Leu Ala Leu Val Leu Val Ala Val
          35                  40                  45

 acg ggt aat gcc atc gtc atc tgg atc atc ctg gcc cat cgg agg atg      192
 Thr Gly Asn Ala Ile Val Ile Trp Ile Ile Leu Ala His Arg Arg Met
      50                  55                  60

 cgc aca gtc acc aac tac ttc atc gtc aat ctg gcg ctg gct gac ctc      240
 Arg Thr Val Thr Asn Tyr Phe Ile Val Asn Leu Ala Leu Ala Asp Leu
  65                  70                  75                  80

 tgc atg gct gcc ttc aat gcc gcc ttc aac ttt gtc tat gcc agc cac      288
 Cys Met Ala Ala Phe Asn Ala Ala Phe Asn Phe Val Tyr Ala Ser His
                  85                  90                  95

 aac atc tgg tac ttt ggc cgt gcc ttc tgc tac ttc cag aac ctc ttc      336
 Asn Ile Trp Tyr Phe Gly Arg Ala Phe Cys Tyr Phe Gln Asn Leu Phe
             100                 105                 110

 ccc atc aca gcc atg tac atg gcc atc gtc cac ccc ttc cag cct cgg      384
 Pro Ile Thr Ala Met Tyr Met Ala Ile Val His Pro Phe Gln Pro Arg
         115                 120                 125

 ctt tca gct ccc agc acc aag gcg gtt att gct ggc atc tgg ctg gtg      432
 Leu Ser Ala Pro Ser Thr Lys Ala Val Ile Ala Gly Ile Trp Leu Val
     130                 135                 140

 gct ctc gcc ctg gcc tcc cct cag tgc ttc tac tcc acc gtc acc atg      480
 Ala Leu Ala Leu Ala Ser Pro Gln Cys Phe Tyr Ser Thr Val Thr Met
 145                 150                 155                 160

 gac cag ggt gcc acc aag tgc gtg gtg gcc tgg ccc gaa gac agc ggg      528
 Asp Gln Gly Ala Thr Lys Cys Val Val Ala Trp Pro Glu Asp Ser Gly
                 165                 170                 175

 ggc aag acg ctc ctc ctg tac cac ctc gtg gtg atc gcc ctc atc tac      576
 Gly Lys Thr Leu Leu Leu Tyr His Leu Val Val Ile Ala Leu Ile Tyr
             180                 185                 190

 ttc ctg ccg ctc gcg gtg atg ttt gta gcc tac agc gtc atc ggc ctc      624
 Phe Leu Pro Leu Ala Val Met Phe Val Ala Tyr Ser Val Ile Gly Leu
         195                 200                 205

 acg ctc tgg agg cgc gca gtg ccc gga cat cag gcg cac ggt gcc aac      672
 Thr Leu Trp Arg Arg Ala Val Pro Gly His Gln Ala His Gly Ala Asn
     210                 215                 220

 ctg cgc cac ctg cag gcc aag aag aag ttt gtg aag acc atg gtg ctg      720
 Leu Arg His Leu Gln Ala Lys Lys Lys Phe Val Lys Thr Met Val Leu
 225                 230                 235                 240

 gtg gtg ctg acg ttt gcc atc tgc tgg ctg ccc tac cac ctc tac ttc      768
 Val Val Leu Thr Phe Ala Ile Cys Trp Leu Pro Tyr His Leu Tyr Phe
                 245                 250                 255

 atc ctg ggc agc ttc cag gag gac atc tac tgc cac aag ttc atc cag      816
 Ile Leu Gly Ser Phe Gln Glu Asp Ile Tyr Cys His Lys Phe Ile Gln
             260                 265                 270

 caa gtc tac ctg gca ctc ttc tgg ttg gcc atg agc tct acc atg tac      864
 Gln Val Tyr Leu Ala Leu Phe Trp Leu Ala Met Ser Ser Thr Met Tyr
         275                 280                 285

 aat ccc atc atc tac tgc tgt ctc aac cac agg ttt cgc tct gga ttc      912
 Asn Pro Ile Ile Tyr Cys Cys Leu Asn His Arg Phe Arg Ser Gly Phe
     290                 295                 300

 cgg ctt gcc ttc cgc tgc tgc cca tgg gtc aca ccc acc aag gaa gat      960
 Arg Leu Ala Phe Arg Cys Cys Pro Trp Val Thr Pro Thr Lys Glu Asp
 305                 310                 315                 320

 aag ctc gag ctg act ccc acg acc tcc ctc tcc acg aga gga gac aac     1008
 Lys Leu Glu Leu Thr Pro Thr Thr Ser Leu Ser Thr Arg Gly Asp Asn
                 325                 330                 335

 ttg gac caa ctc atc ctg gcc gtg gca gag gat ggc ctg att cct ggg     1056
 Leu Asp Gln Leu Ile Leu Ala Val Ala Glu Asp Gly Leu Ile Pro Gly
             340                 345                 350

 ggc ttg aga caa agg gca gac act gcc att tca gac atg ccc cct ttt     1104
 Gly Leu Arg Gln Arg Ala Asp Thr Ala Ile Ser Asp Met Pro Pro Phe
         355                 360                 365

 cac cca agg tta aaa ctg aga gaa gag gag ctc cag aaa cgg aag atg     1152
 His Pro Arg Leu Lys Leu Arg Glu Glu Glu Leu Gln Lys Arg Lys Met
     370                 375                 380

 atg gga gtg gga gat gca aag aaa gcc aaa aca tgg aaa cca tac atc     1200
 Met Gly Val Gly Asp Ala Lys Lys Ala Lys Thr Trp Lys Pro Tyr Ile
 385                 390                 395                 400

 ttg cct atg gga gtc ctg agc aaa gag atc aat tga                     1236
 Leu Pro Met Gly Val Leu Ser Lys Glu Ile Asn 
                 405                 410





      <210> 821
      <211> 1017
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (1)..(1017)

      <400> 821
  atg tcg gcc ccc acc tgc ctg gcc cac ttg cct ccc tgc ttc ctg ctg      48
  Met Ser Ala Pro Thr Cys Leu Ala His Leu Pro Pro Cys Phe Leu Leu
    1               5                  10                  15

 ctg gca ctg gtc ctt gtc ccc tca gat gcc tct ggg cag agc agc agg       96
 Leu Ala Leu Val Leu Val Pro Ser Asp Ala Ser Gly Gln Ser Ser Arg
              20                  25                  30

 aat gac tgg cag gtg cta cag ccc gag ggc ccc atg ctg gtg gca gaa      144
 Asn Asp Trp Gln Val Leu Gln Pro Glu Gly Pro Met Leu Val Ala Glu
          35                  40                  45

 ggt gag aca ctt cta ctg agg tgt atg gtg gtc ggc tcc tgc act gat      192
 Gly Glu Thr Leu Leu Leu Arg Cys Met Val Val Gly Ser Cys Thr Asp
      50                  55                  60

 ggt atg ata aaa tgg gtg aag gtg agc act cag gac caa cag gaa att      240
 Gly Met Ile Lys Trp Val Lys Val Ser Thr Gln Asp Gln Gln Glu Ile
  65                  70                  75                  80

 tat aac ttt aaa cgt ggc tcc ttc cct ggg gta atg ccc atg atc caa      288
 Tyr Asn Phe Lys Arg Gly Ser Phe Pro Gly Val Met Pro Met Ile Gln
                  85                  90                  95

 cgg aca tca gaa cca ctg aat tgt gat tat tcc atc tat atc cac aat      336
 Arg Thr Ser Glu Pro Leu Asn Cys Asp Tyr Ser Ile Tyr Ile His Asn
             100                 105                 110

 gtc acc agg gag cac act gga acc tac cac tgt gtg agg ttt gat ggt      384
 Val Thr Arg Glu His Thr Gly Thr Tyr His Cys Val Arg Phe Asp Gly
         115                 120                 125

 ttg agt gaa cac tca gaa atg aaa tcg gat gaa ggc acc tca gtg ctt      432
 Leu Ser Glu His Ser Glu Met Lys Ser Asp Glu Gly Thr Ser Val Leu
     130                 135                 140

 gtg aag gga gct ggg gac cct gaa cca gac ctg tgg atc atc cag ccc      480
 Val Lys Gly Ala Gly Asp Pro Glu Pro Asp Leu Trp Ile Ile Gln Pro
 145                 150                 155                 160

 cag gaa ttg gtg ttg ggg acc act gga gac act gtc ttt ctg aac tgc      528
 Gln Glu Leu Val Leu Gly Thr Thr Gly Asp Thr Val Phe Leu Asn Cys
                 165                 170                 175

 aca gtg ctt gga gac ggt ccc cct gga ccc atc agg tgg ttc cag gga      576
 Thr Val Leu Gly Asp Gly Pro Pro Gly Pro Ile Arg Trp Phe Gln Gly
             180                 185                 190

 gct ggt ctg agc cgg gag gcc att tac aac ttt gga ggc atc tcc cac      624
 Ala Gly Leu Ser Arg Glu Ala Ile Tyr Asn Phe Gly Gly Ile Ser His
         195                 200                 205

 ccc aag gag aca gcg gtg cag gcc tcc aac aat gac ttc agc att ctt      672
 Pro Lys Glu Thr Ala Val Gln Ala Ser Asn Asn Asp Phe Ser Ile Leu
     210                 215                 220

 ctg caa aac gtc tcc agt gag gat gca ggc acc tat tac tgt gta aag      720
 Leu Gln Asn Val Ser Ser Glu Asp Ala Gly Thr Tyr Tyr Cys Val Lys
 225                 230                 235                 240

 ttt cag agg aaa ccc aac agg caa tac ctg tct gga cag ggc acc agc      768
 Phe Gln Arg Lys Pro Asn Arg Gln Tyr Leu Ser Gly Gln Gly Thr Ser
                 245                 250                 255

 ctg aaa gtg aaa gca aaa tct acc tct tcc aaa gag gca gaa ttc acc      816
 Leu Lys Val Lys Ala Lys Ser Thr Ser Ser Lys Glu Ala Glu Phe Thr
             260                 265                 270

 agt gaa cct gca act gag atg tct cca aca ggc ctc ctg gtt gtg ttc      864
 Ser Glu Pro Ala Thr Glu Met Ser Pro Thr Gly Leu Leu Val Val Phe
         275                 280                 285

 gca cct gtg gtc ctg ggg ctg aag gca att acc ttg gct gca ctc cta      912
 Ala Pro Val Val Leu Gly Leu Lys Ala Ile Thr Leu Ala Ala Leu Leu
     290                 295                 300

 ctg gcc ctg gct acc tct cgg agg agc cct ggg caa gaa gat gtc aag      960
 Leu Ala Leu Ala Thr Ser Arg Arg Ser Pro Gly Gln Glu Asp Val Lys
 305                 310                 315                 320

 acc aca ggc cca gca gga gcc atg aac acc tta gca tgg agc aag ggt     1008
 Thr Thr Gly Pro Ala Gly Ala Met Asn Thr Leu Ala Trp Ser Lys Gly
                 325                 330                 335

 caa gag tga                                                         1017
 Gln Glu 






      <210> 822
      <211> 573
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (1)..(573)

      <400> 822
  atg ggc ccc ccg agc ctc gtg ctg tgc ttg ctg tcc gca act gtg ttc      48
  Met Gly Pro Pro Ser Leu Val Leu Cys Leu Leu Ser Ala Thr Val Phe
    1               5                  10                  15

 tcc ctg ctg ggt gga agc tcg gcc ttc ctg tcg cac cac cgc ctg aaa       96
 Ser Leu Leu Gly Gly Ser Ser Ala Phe Leu Ser His His Arg Leu Lys
              20                  25                  30

 ggc agg ttt cag agg gac cgc agg aac atc cgc ccc aac atc atc ctg      144
 Gly Arg Phe Gln Arg Asp Arg Arg Asn Ile Arg Pro Asn Ile Ile Leu
          35                  40                  45

 gtg ctg acg gac gac cag gat gtg gag ctg gtt ggg gac atc cct gtg      192
 Val Leu Thr Asp Asp Gln Asp Val Glu Leu Val Gly Asp Ile Pro Val
      50                  55                  60

 tct caa tgg ccc tct gag acc aac gga ctt ttg ctg gac ttc cgc tcc      240
 Ser Gln Trp Pro Ser Glu Thr Asn Gly Leu Leu Leu Asp Phe Arg Ser
  65                  70                  75                  80

 aaa aga ata aga ggg aag cac atg gag ccg ctg atc act aga gga gaa      288
 Lys Arg Ile Arg Gly Lys His Met Glu Pro Leu Ile Thr Arg Gly Glu
                  85                  90                  95

 aaa aca tgt gga tgc agg tta tct cag gaa gaa gag agg ctc att cgg      336
 Lys Thr Cys Gly Cys Arg Leu Ser Gln Glu Glu Glu Arg Leu Ile Arg
             100                 105                 110

 acc cac act ggt gtt cag ctt gcc aag cac att cct gtg aag agg gtg      384
 Thr His Thr Gly Val Gln Leu Ala Lys His Ile Pro Val Lys Arg Val
         115                 120                 125

 gcc cag gga caa gag cgg aag cag gga gat cag gtg gtg ttt gca gca      432
 Ala Gln Gly Gln Glu Arg Lys Gln Gly Asp Gln Val Val Phe Ala Ala
     130                 135                 140

 gtc cag gtg gga gat gct ggt ggt acg gag cag gac ggg gca ctg cag      480
 Val Gln Val Gly Asp Ala Gly Gly Thr Glu Gln Asp Gly Ala Leu Gln
 145                 150                 155                 160

 agc gag aga gaa tct cag tcc tgc ctc ctc gac atc tgc cta att gat      528
 Ser Glu Arg Glu Ser Gln Ser Cys Leu Leu Asp Ile Cys Leu Ile Asp
                 165                 170                 175

 ttt ggg ttt agg aac cga ttt gga gcc ttg gct ttt cgt agc tga          573
 Phe Gly Phe Arg Asn Arg Phe Gly Ala Leu Ala Phe Arg Ser 
             180                 185                 190





      <210> 823
      <211> 1479
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (1)..(1479)

      <400> 823
  atg gcg ggg ctc tgg ctg ggg ctc gtg tgg cag aag ctg ctg ctg tgg      48
  Met Ala Gly Leu Trp Leu Gly Leu Val Trp Gln Lys Leu Leu Leu Trp
    1               5                  10                  15

 ggc gcg gcg agt gcc gtt tcc ctg gcc ggc gcc agt ctg gtc ctg agc       96
 Gly Ala Ala Ser Ala Val Ser Leu Ala Gly Ala Ser Leu Val Leu Ser
              20                  25                  30

 ctg ctg cag agg gtg gcg agc tac gcg cgg aaa tgg cag cag atg cgg      144
 Leu Leu Gln Arg Val Ala Ser Tyr Ala Arg Lys Trp Gln Gln Met Arg
          35                  40                  45

 ccc atc ccc acg gtg gcc cgc gcc tac cca ctg gtg ggc cac gcg ctg      192
 Pro Ile Pro Thr Val Ala Arg Ala Tyr Pro Leu Val Gly His Ala Leu
      50                  55                  60

 ctg atg aag ccg gac ggg cga gaa ttt ttt cag cag atc att gag tac      240
 Leu Met Lys Pro Asp Gly Arg Glu Phe Phe Gln Gln Ile Ile Glu Tyr
  65                  70                  75                  80

 aca gag gaa tac cgc cac atg ccg ctg ctg aag ctc tgg gtc ggg cca      288
 Thr Glu Glu Tyr Arg His Met Pro Leu Leu Lys Leu Trp Val Gly Pro
                  85                  90                  95

 gtg ccc atg gtg gcc ctt tat aat gca gaa aat gtg gag aat cct ggc      336
 Val Pro Met Val Ala Leu Tyr Asn Ala Glu Asn Val Glu Asn Pro Gly
             100                 105                 110

 tca gag aag aga gca aga agg gca gac agg att tct gcc gct gtt ggc      384
 Ser Glu Lys Arg Ala Arg Arg Ala Asp Arg Ile Ser Ala Ala Val Gly
         115                 120                 125

 cta gtg tta ata gaa gtt ggt gtg gtg gat gca gat gga gat ctg tcc      432
 Leu Val Leu Ile Glu Val Gly Val Val Asp Ala Asp Gly Asp Leu Ser
     130                 135                 140

 aga gta ggg gac ttg agc aag aag cct gat ata ttt ttt gta acc aca      480
 Arg Val Gly Asp Leu Ser Lys Lys Pro Asp Ile Phe Phe Val Thr Thr
 145                 150                 155                 160

 tat ttt att tct agt act gga aac aaa tgg cgc tcc agg aga aag atg      528
 Tyr Phe Ile Ser Ser Thr Gly Asn Lys Trp Arg Ser Arg Arg Lys Met
                 165                 170                 175

 tta aca ccc act ttc cat ttt acc att ctg gaa gat ttc tta gat atc      576
 Leu Thr Pro Thr Phe His Phe Thr Ile Leu Glu Asp Phe Leu Asp Ile
             180                 185                 190

 atg aat gaa caa gca aat ata ttg gtt aag aaa ctt gaa aaa cac att      624
 Met Asn Glu Gln Ala Asn Ile Leu Val Lys Lys Leu Glu Lys His Ile
         195                 200                 205

 aac caa gaa gca ttt aac tgc ttt ttt tac atc act ctt tgt gcc tta      672
 Asn Gln Glu Ala Phe Asn Cys Phe Phe Tyr Ile Thr Leu Cys Ala Leu
     210                 215                 220

 gat atc atc tgt gga aat cac act cca ctg gga agg caa atg ggg gga      720
 Asp Ile Ile Cys Gly Asn His Thr Pro Leu Gly Arg Gln Met Gly Gly
 225                 230                 235                 240

 cgg gaa agg gtg acg ggc tct tca gcg cgg ttc tac gac cgc act ggc      768
 Arg Glu Arg Val Thr Gly Ser Ser Ala Arg Phe Tyr Asp Arg Thr Gly
                 245                 250                 255

 ctt ctg agg agc agc agc cac gcc cag ggc tgt gag tgg ggc agg cat      816
 Leu Leu Arg Ser Ser Ser His Ala Gln Gly Cys Glu Trp Gly Arg His
             260                 265                 270

 gga gca act gcc cag gga ggc gaa ggg aag gaa gaa cag gaa cag gga      864
 Gly Ala Thr Ala Gln Gly Gly Glu Gly Lys Glu Glu Gln Glu Gln Gly
         275                 280                 285

 gta gaa gtg gac cgt aca aga gaa gag gaa aca gct atg ggg aag aat      912
 Val Glu Val Asp Arg Thr Arg Glu Glu Glu Thr Ala Met Gly Lys Asn
     290                 295                 300

 att ggt gct caa agt aat gat gat tcc gag tat gtc cgt gca gtt tat      960
 Ile Gly Ala Gln Ser Asn Asp Asp Ser Glu Tyr Val Arg Ala Val Tyr
 305                 310                 315                 320

 aga atg agt gag atg ata ttt cga aga ata aag atg ccc tgg ctt tgg     1008
 Arg Met Ser Glu Met Ile Phe Arg Arg Ile Lys Met Pro Trp Leu Trp
                 325                 330                 335

 ctt gat ctc tgg tac ctt atg ttt aaa gaa gga tgg gaa cac aaa aag     1056
 Leu Asp Leu Trp Tyr Leu Met Phe Lys Glu Gly Trp Glu His Lys Lys
             340                 345                 350

 agc ctt cag atc cta cat act ttt acc aac agt gtc atc gct gaa cgg     1104
 Ser Leu Gln Ile Leu His Thr Phe Thr Asn Ser Val Ile Ala Glu Arg
         355                 360                 365

 gcc aat gaa atg aac gcc aat gaa gac tgt aga ggt gat ggc agg ggc     1152
 Ala Asn Glu Met Asn Ala Asn Glu Asp Cys Arg Gly Asp Gly Arg Gly
     370                 375                 380

 tct gcc ccc tcc aaa aat aaa cgc agg gcc ttt ctt gac ttg ctt tta     1200
 Ser Ala Pro Ser Lys Asn Lys Arg Arg Ala Phe Leu Asp Leu Leu Leu
 385                 390                 395                 400

 agt gtg act gat gac gaa ggg aac agg cta agt cat gaa gat att cga     1248
 Ser Val Thr Asp Asp Glu Gly Asn Arg Leu Ser His Glu Asp Ile Arg
                 405                 410                 415

 gaa gaa gtt gac acc ttc atg ttt gag gct ggt gca ggc tgc aac tgc     1296
 Glu Glu Val Asp Thr Phe Met Phe Glu Ala Gly Ala Gly Cys Asn Cys
             420                 425                 430

 cca ggt tcc agc tgt gag cta aaa gtg ggc gtc ctc ccc tgc tcc acc     1344
 Pro Gly Ser Ser Cys Glu Leu Lys Val Gly Val Leu Pro Cys Ser Thr
         435                 440                 445

 agt gtg cct cgg tgc ttt acg ttt gcc tta tca tgc ttt ctg cag ttg     1392
 Ser Val Pro Arg Cys Phe Thr Phe Ala Leu Ser Cys Phe Leu Gln Leu
     450                 455                 460

 gca gat gaa atg aaa tcg gaa gtt cag cag act cct ctt atg cat ttg     1440
 Ala Asp Glu Met Lys Ser Glu Val Gln Gln Thr Pro Leu Met His Leu
 465                 470                 475                 480

 gat cag gct tcc gct cat aaa ttc aag gaa agc tat taa                 1479
 Asp Gln Ala Ser Ala His Lys Phe Lys Glu Ser Tyr 
                 485                 490





      <210> 824
      <211> 3216
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (1)..(3216)

      <400> 824
  atg gat aag cct cgc cct ggg aaa acc acc ttc gtg atc atg gta tct      48
  Met Asp Lys Pro Arg Pro Gly Lys Thr Thr Phe Val Ile Met Val Ser
    1               5                  10                  15

 ccc ctg cca ggt atc tat tcc tgc ctg gtg ttt ata agc ctg aca ctt       96
 Pro Leu Pro Gly Ile Tyr Ser Cys Leu Val Phe Ile Ser Leu Thr Leu
              20                  25                  30

 ggc tgg gct tcc ctg ggg tat atc tcc atg gct ctg tgg caa gac ttg      144
 Gly Trp Ala Ser Leu Gly Tyr Ile Ser Met Ala Leu Trp Gln Asp Leu
          35                  40                  45

 aat agg ctg gtg atg aca ctt gat gtc ccc ata gcc acc ttc aaa aat      192
 Asn Arg Leu Val Met Thr Leu Asp Val Pro Ile Ala Thr Phe Lys Asn
      50                  55                  60

 gtc att aaa ggc ttg cga gaa aat gta agg aaa cac aga aaa cct gat      240
 Val Ile Lys Gly Leu Arg Glu Asn Val Arg Lys His Arg Lys Pro Asp
  65                  70                  75                  80

 ttt gaa agt tgc cgc ctc tcc ttc ttc ctc att cag agc gtg tac gat      288
 Phe Glu Ser Cys Arg Leu Ser Phe Phe Leu Ile Gln Ser Val Tyr Asp
                  85                  90                  95

 att gct gtg cga ctc caa cct ctg cct agg ctg cgc ttt tac ctg cga      336
 Ile Ala Val Arg Leu Gln Pro Leu Pro Arg Leu Arg Phe Tyr Leu Arg
             100                 105                 110

 cta gag agg tta caa ctt acc agt gcc ttc gga gct ctg tgc agt gat      384
 Leu Glu Arg Leu Gln Leu Thr Ser Ala Phe Gly Ala Leu Cys Ser Asp
         115                 120                 125

 acc ttc caa ccc cct ttc tgt gct tcc ttc cct aga aaa aac cga aga      432
 Thr Phe Gln Pro Pro Phe Cys Ala Ser Phe Pro Arg Lys Asn Arg Arg
     130                 135                 140

 gtg aca atc ctc agc aat ccg cta ttt cgc ttc act gac aag gga gaa      480
 Val Thr Ile Leu Ser Asn Pro Leu Phe Arg Phe Thr Asp Lys Gly Glu
 145                 150                 155                 160

 gca ctc aag gag ttt tct ctg att ctc acc cta agt ctt ctg gag aca      528
 Ala Leu Lys Glu Phe Ser Leu Ile Leu Thr Leu Ser Leu Leu Glu Thr
                 165                 170                 175

 aaa ctc atg aag gaa ttg cga aaa gcc ttg cag cag cta caa gaa ttg      576
 Lys Leu Met Lys Glu Leu Arg Lys Ala Leu Gln Gln Leu Gln Glu Leu
             180                 185                 190

 cag aat aag agc caa cag ctt cgt gcc tgg gag gct gaa aaa tac aat      624
 Gln Asn Lys Ser Gln Gln Leu Arg Ala Trp Glu Ala Glu Lys Tyr Asn
         195                 200                 205

 gag att cga acc cag gaa caa aac gtc cag cac cta aac cat agt ctg      672
 Glu Ile Arg Thr Gln Glu Gln Asn Val Gln His Leu Asn His Ser Leu
     210                 215                 220

 agt cac aag gag cag ttg ctt cag gaa ttt cgg gag ctc cta cag tat      720
 Ser His Lys Glu Gln Leu Leu Gln Glu Phe Arg Glu Leu Leu Gln Tyr
 225                 230                 235                 240

 cga gat aac tca gac aaa acc ctt gaa gca aat gaa acg ttg ctt gag      768
 Arg Asp Asn Ser Asp Lys Thr Leu Glu Ala Asn Glu Thr Leu Leu Glu
                 245                 250                 255

 aaa ctt cgc cag cga ata cat gat aaa gct gtt gct ctg gag cac tcc      816
 Lys Leu Arg Gln Arg Ile His Asp Lys Ala Val Ala Leu Glu His Ser
             260                 265                 270

 cag gag atg gaa agc ctg agg gag gct ctg ctg tcc tct cga tcc cac      864
 Gln Glu Met Glu Ser Leu Arg Glu Ala Leu Leu Ser Ser Arg Ser His
         275                 280                 285

 ctt caa gag ctg gaa gag gag ctg gag cac cag aag gtg gaa agg cag      912
 Leu Gln Glu Leu Glu Glu Glu Leu Glu His Gln Lys Val Glu Arg Gln
     290                 295                 300

 cag ctt ttg gaa gac ttg agg gag aag cag caa gag gtc ttg cat ttc      960
 Gln Leu Leu Glu Asp Leu Arg Glu Lys Gln Gln Glu Val Leu His Phe
 305                 310                 315                 320

 agg gag gaa cgc ctt tcc ctc cag gaa aac gac tcc aga ctg aag cac     1008
 Arg Glu Glu Arg Leu Ser Leu Gln Glu Asn Asp Ser Arg Leu Lys His
                 325                 330                 335

 aag ctg gtt ctc ctg cag caa cag tgt gaa gag aaa cag cag ctc ttt     1056
 Lys Leu Val Leu Leu Gln Gln Gln Cys Glu Glu Lys Gln Gln Leu Phe
             340                 345                 350

 gag tcc ctc cag tca gag tta caa atc tat gag gca ctt tat ggc aat     1104
 Glu Ser Leu Gln Ser Glu Leu Gln Ile Tyr Glu Ala Leu Tyr Gly Asn
         355                 360                 365

 tcc aag aag ggg ctg aaa gct tac agc ctg gat gtc tgt cac caa atc     1152
 Ser Lys Lys Gly Leu Lys Ala Tyr Ser Leu Asp Val Cys His Gln Ile
     370                 375                 380

 cct ttg agc agt gac ttg agc cac ctg gtg gca gag aac ttc cca gcc     1200
 Pro Leu Ser Ser Asp Leu Ser His Leu Val Ala Glu Asn Phe Pro Ala
 385                 390                 395                 400

 agc gct gac cct gga aac aag cag ctg ctc ctc caa ggc ttg ggt ttg     1248
 Ser Ala Asp Pro Gly Asn Lys Gln Leu Leu Leu Gln Gly Leu Gly Leu
                 405                 410                 415

 gat act tct cca gta atg aag gcc cct ccc aag ctg gag ggt gat gct     1296
 Asp Thr Ser Pro Val Met Lys Ala Pro Pro Lys Leu Glu Gly Asp Ala
             420                 425                 430

 act gat ggc tcc ttt gcc aat aag cat ggc cgc cat gtc att ggc cac     1344
 Thr Asp Gly Ser Phe Ala Asn Lys His Gly Arg His Val Ile Gly His
         435                 440                 445

 att gat gac tac agt gcc cta aga cag cag att gtg gag ggc aag ctg     1392
 Ile Asp Asp Tyr Ser Ala Leu Arg Gln Gln Ile Val Glu Gly Lys Leu
     450                 455                 460

 ctg gtc aaa aag ata gtg tct ctt gtg aga tca gcg tgc agc ttc cct     1440
 Leu Val Lys Lys Ile Val Ser Leu Val Arg Ser Ala Cys Ser Phe Pro
 465                 470                 475                 480

 ggc ctt gaa gcc caa ggc aca ggg gtg cta ggc agc aaa ggc att cat     1488
 Gly Leu Glu Ala Gln Gly Thr Gly Val Leu Gly Ser Lys Gly Ile His
                 485                 490                 495

 gag ctt tgg agc agc acc agt gcc ctg cac cat gcc cta gag gag tcg     1536
 Glu Leu Trp Ser Ser Thr Ser Ala Leu His His Ala Leu Glu Glu Ser
             500                 505                 510

 gct tcc ctc ctc acc atg ttc tgg aga gtg gcc ctg cca agc acc cac     1584
 Ala Ser Leu Leu Thr Met Phe Trp Arg Val Ala Leu Pro Ser Thr His
         515                 520                 525

 atc cct gtg ctg cct ggc aaa gtg ctg gag gta ttc aag gct gtg aag     1632
 Ile Pro Val Leu Pro Gly Lys Val Leu Glu Val Phe Lys Ala Val Lys
     530                 535                 540

 gag gaa atc cag ttc agg agg gtt gag aag att gta gaa tcc ttt gaa     1680
 Glu Glu Ile Gln Phe Arg Arg Val Glu Lys Ile Val Glu Ser Phe Glu
 545                 550                 555                 560

 ctg gaa aga gcc aca aag cac agg gtg ctt tat gtc ttc tgc ctg aga     1728
 Leu Glu Arg Ala Thr Lys His Arg Val Leu Tyr Val Phe Cys Leu Arg
                 565                 570                 575

 gaa tcg aca gaa agg gaa ctt cta gaa ctg aga acc aaa gta tcc aaa     1776
 Glu Ser Thr Glu Arg Glu Leu Leu Glu Leu Arg Thr Lys Val Ser Lys
             580                 585                 590

 cag gag tgg ctc ctt cag agc aca gct gag cat ctg aag atc gcc aac     1824
 Gln Glu Trp Leu Leu Gln Ser Thr Ala Glu His Leu Lys Ile Ala Asn
         595                 600                 605

 cag cag aaa gag agc atg gag cag ttc atc gtc agc cag cgt gaa atc     1872
 Gln Gln Lys Glu Ser Met Glu Gln Phe Ile Val Ser Gln Arg Glu Ile
     610                 615                 620

 cct aag ggc tct gcc atg tac tcc agc ctt gtg acc ctt gcc ttc cag     1920
 Pro Lys Gly Ser Ala Met Tyr Ser Ser Leu Val Thr Leu Ala Phe Gln
 625                 630                 635                 640

 gaa cca tgc aag aag cgc agc cac cgg aag tcc tta aaa cag cag gaa     1968
 Glu Pro Cys Lys Lys Arg Ser His Arg Lys Ser Leu Lys Gln Gln Glu
                 645                 650                 655

 agg ttg gcc tgt ccc cct ttt ata ttg aca aac atc aac agt atc aat     2016
 Arg Leu Ala Cys Pro Pro Phe Ile Leu Thr Asn Ile Asn Ser Ile Asn
             660                 665                 670

 aac att gaa gcc aat atg acc tca aca aat gga cca agc ttc cag ctg     2064
 Asn Ile Glu Ala Asn Met Thr Ser Thr Asn Gly Pro Ser Phe Gln Leu
         675                 680                 685

 aga cta cag ttt cat tac aac cta tat gca ccc ata ggt cct gcc tgt     2112
 Arg Leu Gln Phe His Tyr Asn Leu Tyr Ala Pro Ile Gly Pro Ala Cys
     690                 695                 700

 ggc aat gaa gtc tct cgg gtc agt aag ggc cac ttg gaa cag gaa tat     2160
 Gly Asn Glu Val Ser Arg Val Ser Lys Gly His Leu Glu Gln Glu Tyr
 705                 710                 715                 720

 cac ccc tat ctg gaa ggc cag gtg gag gct tat cac ctt cat agt aag     2208
 His Pro Tyr Leu Glu Gly Gln Val Glu Ala Tyr His Leu His Ser Lys
                 725                 730                 735

 gta ctc act gtc cac gtc aag agc caa gcc aag gat cgc agc tcc tcg     2256
 Val Leu Thr Val His Val Lys Ser Gln Ala Lys Asp Arg Ser Ser Ser
             740                 745                 750

 cca gca atg gaa caa agc agg ata gag aat gac ttt gac gag ctg aca     2304
 Pro Ala Met Glu Gln Ser Arg Ile Glu Asn Asp Phe Asp Glu Leu Thr
         755                 760                 765

 gaa gta ggc ttc aga aag tcg gta ata aca aac ttc tct gag cta aag     2352
 Glu Val Gly Phe Arg Lys Ser Val Ile Thr Asn Phe Ser Glu Leu Lys
     770                 775                 780

 gag gat gtg cga act cat cgc aag gaa gct aaa aac ctt gaa aaa aga     2400
 Glu Asp Val Arg Thr His Arg Lys Glu Ala Lys Asn Leu Glu Lys Arg
 785                 790                 795                 800

 tta gac gaa tgg cta acc aga atg aac agt gta gag aag acc tta aat     2448
 Leu Asp Glu Trp Leu Thr Arg Met Asn Ser Val Glu Lys Thr Leu Asn
                 805                 810                 815

 gac ctg atg gag ctg aaa acc atg gca cga aaa cta cgt gat gca tgc     2496
 Asp Leu Met Glu Leu Lys Thr Met Ala Arg Lys Leu Arg Asp Ala Cys
             820                 825                 830

 aca agc ttc agt agc caa ttc gat caa gtg caa gaa acg ggt gac tgt     2544
 Thr Ser Phe Ser Ser Gln Phe Asp Gln Val Gln Glu Thr Gly Asp Cys
         835                 840                 845

 gca gct aag caa gct gac tta aag gag atc cag atg aaa gct gag agc     2592
 Ala Ala Lys Gln Ala Asp Leu Lys Glu Ile Gln Met Lys Ala Glu Ser
     850                 855                 860

 agt gaa acc tgg gga aca ata ttt cca aat aca aag gca agg ctg cca     2640
 Ser Glu Thr Trp Gly Thr Ile Phe Pro Asn Thr Lys Ala Arg Leu Pro
 865                 870                 875                 880

 gct tcc tta aac agg cat aga aac tcc atg gac att gtt cag gga cag     2688
 Ala Ser Leu Asn Arg His Arg Asn Ser Met Asp Ile Val Gln Gly Gln
                 885                 890                 895

 atg act aaa tca cag atg aca aga gat act gaa tcg aag tta gga ggc     2736
 Met Thr Lys Ser Gln Met Thr Arg Asp Thr Glu Ser Lys Leu Gly Gly
             900                 905                 910

 ctg aca gat act gcc tgt gca cct cct gca ctg aga atg ttc atc tct     2784
 Leu Thr Asp Thr Ala Cys Ala Pro Pro Ala Leu Arg Met Phe Ile Ser
         915                 920                 925

 gcc ttc tcg ctg gac aaa ggg ccg gct gat acc acc atg ctg acg ttt     2832
 Ala Phe Ser Leu Asp Lys Gly Pro Ala Asp Thr Thr Met Leu Thr Phe
     930                 935                 940

 gtg gca gaa gag gaa caa gag cct gtg cac cag gaa gca gac ttc act     2880
 Val Ala Glu Glu Glu Gln Glu Pro Val His Gln Glu Ala Asp Phe Thr
 945                 950                 955                 960

 ctc acc aag gac acg gcc att gtg ggc aac aag gac cca cct tcc atc     2928
 Leu Thr Lys Asp Thr Ala Ile Val Gly Asn Lys Asp Pro Pro Ser Ile
                 965                 970                 975

 tgt gcc acc gtc cca ggg aaa acc ttc ctc aac atc acg cca gct gag     2976
 Cys Ala Thr Val Pro Gly Lys Thr Phe Leu Asn Ile Thr Pro Ala Glu
             980                 985                 990

 gtt ggt gtc ctg gtt ggc aaa gac tgg tca agc ttt gtc atg aat ggg     3024
 Val Gly Val Leu Val Gly Lys Asp Trp Ser Ser Phe Val Met Asn Gly
         995                1000                1005

 ctg aca ctg ggg ggc cag aaa tat act gtg gtc ctg gac tca ctg ctg     3072
 Leu Thr Leu Gly Gly Gln Lys Tyr Thr Val Val Leu Asp Ser Leu Leu
    1010                1015                1020

 cag gat ggg gaa ttg acc acg gat ctt tgt atg aag agc atc ggt gga     3120
 Gln Asp Gly Glu Leu Thr Thr Asp Leu Cys Met Lys Ser Ile Gly Gly
1025                1030                1035                1040

 gcc ccc acc ttc aac gtc att gtc acc atg act gcc aag acg cta ggc     3168
 Ala Pro Thr Phe Asn Val Ile Val Thr Met Thr Ala Lys Thr Leu Gly
                1045                1050                1055

 ctg ctg atg ggc aaa gaa ggt atc cat ggc aat ttc atc aac aag taa     3216
 Leu Leu Met Gly Lys Glu Gly Ile His Gly Asn Phe Ile Asn Lys 
            1060                1065                1070





      <210> 825
      <211> 885
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (1)..(885)

      <400> 825
  atg act ata gcc acc agc tac ctg ggt gtg ttg gca gcc ttg gca ttt      48
  Met Thr Ile Ala Thr Ser Tyr Leu Gly Val Leu Ala Ala Leu Ala Phe
    1               5                  10                  15

 ctt gga gct gtc ctc acc ccc ttg ttt cat ttt tac atc tct act tat       96
 Leu Gly Ala Val Leu Thr Pro Leu Phe His Phe Tyr Ile Ser Thr Tyr
              20                  25                  30

 ctt aaa acc caa gga gcc ttc tat att tgt ggc cag cca gtt cac cag      144
 Leu Lys Thr Gln Gly Ala Phe Tyr Ile Cys Gly Gln Pro Val His Gln
          35                  40                  45

 tgc ctc ccc act aac cgg act gga act tgt acc ata ggc tat gta tcc      192
 Cys Leu Pro Thr Asn Arg Thr Gly Thr Cys Thr Ile Gly Tyr Val Ser
      50                  55                  60

 cta gac atc ttc ata gtc cct ggc aat ctc tct ctt cca gca cca atc      240
 Leu Asp Ile Phe Ile Val Pro Gly Asn Leu Ser Leu Pro Ala Pro Ile
  65                  70                  75                  80

 tac agg cat tcc atc ttt tcc agg atg agg agg gct atc caa tta att      288
 Tyr Arg His Ser Ile Phe Ser Arg Met Arg Arg Ala Ile Gln Leu Ile
                  85                  90                  95

 ctc ctt ctc aca gga ctt ggt att ata gcc agt atg gga acc aga att      336
 Leu Leu Leu Thr Gly Leu Gly Ile Ile Ala Ser Met Gly Thr Arg Ile
             100                 105                 110

 gct aga atc aca aaa gcc tcc ttg acc cat agc cag ccc tca agg gaa      384
 Ala Arg Ile Thr Lys Ala Ser Leu Thr His Ser Gln Pro Ser Arg Glu
         115                 120                 125

 ata gcc aag aac att gat gct acg gct aaa acc tta aca act gtg caa      432
 Ile Ala Lys Asn Ile Asp Ala Thr Ala Lys Thr Leu Thr Thr Val Gln
     130                 135                 140

 gaa caa att gac tct ttg gca gct ata gtc ctc caa aat tat cag gag      480
 Glu Gln Ile Asp Ser Leu Ala Ala Ile Val Leu Gln Asn Tyr Gln Glu
 145                 150                 155                 160

 tta gac aag tta aca gca gca cag aga gaa act tgt tta gcc tta ggt      528
 Leu Asp Lys Leu Thr Ala Ala Gln Arg Glu Thr Cys Leu Ala Leu Gly
                 165                 170                 175

 gaa aaa ttt tgc tta tgg gtc aat caa tca gga aaa gta caa tat cag      576
 Glu Lys Phe Cys Leu Trp Val Asn Gln Ser Gly Lys Val Gln Tyr Gln
             180                 185                 190

 aca act cct aaa ttg agc ctc cag ttt act gga aca agc ctc tca ggg      624
 Thr Thr Pro Lys Leu Ser Leu Gln Phe Thr Gly Thr Ser Leu Ser Gly
         195                 200                 205

 ttg gcc atc aag ctt cag atg atc ctc agt gag aga tac cat cgt ctc      672
 Leu Ala Ile Lys Leu Gln Met Ile Leu Ser Glu Arg Tyr His Arg Leu
     210                 215                 220

 aat att caa gag tca cac ttc tac aga gga cca cta gac tgc cca tca      720
 Asn Ile Gln Glu Ser His Phe Tyr Arg Gly Pro Leu Asp Cys Pro Ser
 225                 230                 235                 240

 gtg aga cat gaa aga agc gaa atc ctg ccc ctg tct ccc ttg gac ctt      768
 Val Arg His Glu Arg Ser Glu Ile Leu Pro Leu Ser Pro Leu Asp Leu
                 245                 250                 255

 gct gga tac cac ttt cac caa ccc aca aag cca ccc tgc cct gac agc      816
 Ala Gly Tyr His Phe His Gln Pro Thr Lys Pro Pro Cys Pro Asp Ser
             260                 265                 270

 aag acg cca aga ccc aca gaa caa tca tca ccg tcc ttc tgt cag cag      864
 Lys Thr Pro Arg Pro Thr Glu Gln Ser Ser Pro Ser Phe Cys Gln Gln
         275                 280                 285

 gaa gca gtt aca gaa gac tga                                          885
 Glu Ala Val Thr Glu Asp 
     290





      <210> 826
      <211> 612
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (1)..(612)

      <400> 826
  atg gtg ctc aag gtg gcg ggg cct gca tgt gcc gtg gtt ggg ctt ggg      48
  Met Val Leu Lys Val Ala Gly Pro Ala Cys Ala Val Val Gly Leu Gly
    1               5                  10                  15

 gct gtg atc ctg gcc cgc tcc cgg gcg caa ctt cag ctc ggt gca ggg       96
 Ala Val Ile Leu Ala Arg Ser Arg Ala Gln Leu Gln Leu Gly Ala Gly
              20                  25                  30

 ctg cag aga ggt cag cag atg gac ccc gac cga gcc ttc atc tgt gga      144
 Leu Gln Arg Gly Gln Gln Met Asp Pro Asp Arg Ala Phe Ile Cys Gly
          35                  40                  45

 gag agc cgc cag ttt gcc cag tgc ctt atc ttt ggg ttt ctg ttc ttg      192
 Glu Ser Arg Gln Phe Ala Gln Cys Leu Ile Phe Gly Phe Leu Phe Leu
      50                  55                  60

 aca agc ggc atg ctc atc agc gtc ctg ggc att tgg gtc cct gga tgt      240
 Thr Ser Gly Met Leu Ile Ser Val Leu Gly Ile Trp Val Pro Gly Cys
  65                  70                  75                  80

 ggc tcc aaa tgg gcg cag gaa ccg cta aac gag aca gac act ggc gac      288
 Gly Ser Lys Trp Ala Gln Glu Pro Leu Asn Glu Thr Asp Thr Gly Asp
                  85                  90                  95

 tca gag ccc cgg atg tgt ggg ttc ctt tct ctg cag atc atg ggg ccc      336
 Ser Glu Pro Arg Met Cys Gly Phe Leu Ser Leu Gln Ile Met Gly Pro
             100                 105                 110

 ttg att gtg ctt gtg gga ttg tgt ttc ttc gtg gtt gcc cat gtt aag      384
 Leu Ile Val Leu Val Gly Leu Cys Phe Phe Val Val Ala His Val Lys
         115                 120                 125

 aag aga aac acg ctg aat gct ggc cag gat gcc tct gag aga gaa gag      432
 Lys Arg Asn Thr Leu Asn Ala Gly Gln Asp Ala Ser Glu Arg Glu Glu
     130                 135                 140

 gga cag atc cag att atg gag cct gtc cag gtc act gta gaa tcc aag      480
 Gly Gln Ile Gln Ile Met Glu Pro Val Gln Val Thr Val Glu Ser Lys
 145                 150                 155                 160

 aag cat gct ctc ctt gtt gtg ggt aca ctc agt gct atc ctg gat aca      528
 Lys His Ala Leu Leu Val Val Gly Thr Leu Ser Ala Ile Leu Asp Thr
                 165                 170                 175

 cag cag gta tat gag aca gct ctc ctt gga ggg gtg tat atg ttg tct      576
 Gln Gln Val Tyr Glu Thr Ala Leu Leu Gly Gly Val Tyr Met Leu Ser
             180                 185                 190

 gct cac aga gga cat caa gtt ctg aaa gac gca tga                      612
 Ala His Arg Gly His Gln Val Leu Lys Asp Ala 
         195                 200





      <210> 827
      <211> 516
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (1)..(516)

      <400> 827
  atg gtg gcg gcc gtc ctg ctg ggg ctg agc tgg ctc tgc tct ccc ctg      48
  Met Val Ala Ala Val Leu Leu Gly Leu Ser Trp Leu Cys Ser Pro Leu
    1               5                  10                  15

 gga gct ctg gtc ctg gac ttc aac aac atc agg agc tct gct gac ctg       96
 Gly Ala Leu Val Leu Asp Phe Asn Asn Ile Arg Ser Ser Ala Asp Leu
              20                  25                  30

 cat ggg gcc cgg aag ggc tca cag tgc ctg tct gac acg gac tgc aat      144
 His Gly Ala Arg Lys Gly Ser Gln Cys Leu Ser Asp Thr Asp Cys Asn
          35                  40                  45

 acc aga aag ttc tgc ctc cag ccc cgc gat gag aag ccg ttc tgt gct      192
 Thr Arg Lys Phe Cys Leu Gln Pro Arg Asp Glu Lys Pro Phe Cys Ala
      50                  55                  60

 aca tgt cgt ggg ttg cgg agg agg tgc cag cga gat gcc atg tgc tgc      240
 Thr Cys Arg Gly Leu Arg Arg Arg Cys Gln Arg Asp Ala Met Cys Cys
  65                  70                  75                  80

 cct ggg aca ctc tgt gtg aac gat gtt tgt act acg atg gaa gat gca      288
 Pro Gly Thr Leu Cys Val Asn Asp Val Cys Thr Thr Met Glu Asp Ala
                  85                  90                  95

 acc cca ata tta gaa agg cag ctt gat gag caa gat ggc aca cat gca      336
 Thr Pro Ile Leu Glu Arg Gln Leu Asp Glu Gln Asp Gly Thr His Ala
             100                 105                 110

 gaa gga aca act ggg cac cca gtc cag gaa aac caa ccc aaa agg aag      384
 Glu Gly Thr Thr Gly His Pro Val Gln Glu Asn Gln Pro Lys Arg Lys
         115                 120                 125

 cca agt att aag aaa tca caa ggc agg aag ggc act aac aag ttc caa      432
 Pro Ser Ile Lys Lys Ser Gln Gly Arg Lys Gly Thr Asn Lys Phe Gln
     130                 135                 140

 ctc aac ttc cac ctt caa gtg gat cag aag tca ttt cca cct gga att      480
 Leu Asn Phe His Leu Gln Val Asp Gln Lys Ser Phe Pro Pro Gly Ile
 145                 150                 155                 160

 acc agg agg tat tac ctt gcg gat gcg gat gtc tag                      516
 Thr Arg Arg Tyr Tyr Leu Ala Asp Ala Asp Val 
                 165                 170





      <210> 828
      <211> 1419
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (1)..(1419)

      <400> 828
  atg aat ccc tgt gac agc cct ttg gct gtt acc ccc aga tcc ttt ctc      48
  Met Asn Pro Cys Asp Ser Pro Leu Ala Val Thr Pro Arg Ser Phe Leu
    1               5                  10                  15

 caa acc ctc aac ctg aag gaa ccg cta atc tat ttt ctg tct ctg tgg       96
 Gln Thr Leu Asn Leu Lys Glu Pro Leu Ile Tyr Phe Leu Ser Leu Trp
              20                  25                  30

 aca ttc atc cta tcc att gtg aaa ggg agt cag ctt gcc agc agt cag      144
 Thr Phe Ile Leu Ser Ile Val Lys Gly Ser Gln Leu Ala Ser Ser Gln
          35                  40                  45

 gag cgg gat tct caa agt tgg att ggt gga aac aat gaa cca ttg aca      192
 Glu Arg Asp Ser Gln Ser Trp Ile Gly Gly Asn Asn Glu Pro Leu Thr
      50                  55                  60

 ggc ttt aca tgg cga ggt ggc tgt gaa aga gaa aca aca ggc ata caa      240
 Gly Phe Thr Trp Arg Gly Gly Cys Glu Arg Glu Thr Thr Gly Ile Gln
  65                  70                  75                  80

 gtt tgg aat gaa gta ttt gtg att gac aga cct aat gga act aaa gtt      288
 Val Trp Asn Glu Val Phe Val Ile Asp Arg Pro Asn Gly Thr Lys Val
                  85                  90                  95

 gct gtg ctg ctt atg gat acc cag ggt gcc ttt gat agc cag tca act      336
 Ala Val Leu Leu Met Asp Thr Gln Gly Ala Phe Asp Ser Gln Ser Thr
             100                 105                 110

 atc aaa gac tgt gca acg gtg ttt gct ctg agc act atg act agc tct      384
 Ile Lys Asp Cys Ala Thr Val Phe Ala Leu Ser Thr Met Thr Ser Ser
         115                 120                 125

 gtc cag aca tta atg ttt ttg att cga gat tgg agc tat cct tat gaa      432
 Val Gln Thr Leu Met Phe Leu Ile Arg Asp Trp Ser Tyr Pro Tyr Glu
     130                 135                 140

 cat tca tat ggt ttg gaa ggt gga aag caa ttt ctt gaa aag aga tta      480
 His Ser Tyr Gly Leu Glu Gly Gly Lys Gln Phe Leu Glu Lys Arg Leu
 145                 150                 155                 160

 cag gta aaa caa aat caa cat gaa gag ctt cag aat gta agg aag cac      528
 Gln Val Lys Gln Asn Gln His Glu Glu Leu Gln Asn Val Arg Lys His
                 165                 170                 175

 ata cac aat tgt ttc tca aat ctt ggt tgc ttc ctt ttg cca cat cct      576
 Ile His Asn Cys Phe Ser Asn Leu Gly Cys Phe Leu Leu Pro His Pro
             180                 185                 190

 ggt ctt aaa gtt gca act aat cct agt ttt gat ggg aga ttg aaa gat      624
 Gly Leu Lys Val Ala Thr Asn Pro Ser Phe Asp Gly Arg Leu Lys Asp
         195                 200                 205

 att gat gaa gac ttt aaa cga gag ctt cga aat ctg gtt cca ttg ctg      672
 Ile Asp Glu Asp Phe Lys Arg Glu Leu Arg Asn Leu Val Pro Leu Leu
     210                 215                 220

 ctt gcc cct gaa aat ttg gta gaa aaa gag ata agt gga tct aaa gtc      720
 Leu Ala Pro Glu Asn Leu Val Glu Lys Glu Ile Ser Gly Ser Lys Val
 225                 230                 235                 240

 act tgt aga gat ctt gta gaa tat ttt aag gct tac atc aaa atc tat      768
 Thr Cys Arg Asp Leu Val Glu Tyr Phe Lys Ala Tyr Ile Lys Ile Tyr
                 245                 250                 255

 caa gga gaa gaa ctt cca cat cca aag tcc atg ctt cag gca aca gct      816
 Gln Gly Glu Glu Leu Pro His Pro Lys Ser Met Leu Gln Ala Thr Ala
             260                 265                 270

 gaa gct aat aat ctt gct gca gta gca gga gca aga gat acc tat tgt      864
 Glu Ala Asn Asn Leu Ala Ala Val Ala Gly Ala Arg Asp Thr Tyr Cys
         275                 280                 285

 aaa agt atg gaa cag gta tgt gga ggg gac aag cct tac att gca cct      912
 Lys Ser Met Glu Gln Val Cys Gly Gly Asp Lys Pro Tyr Ile Ala Pro
     290                 295                 300

 tca gat ctg gag cga aaa cac ttg gat ctc aag gaa gtg gcg ata aaa      960
 Ser Asp Leu Glu Arg Lys His Leu Asp Leu Lys Glu Val Ala Ile Lys
 305                 310                 315                 320

 caa ttt cgt tca gta aaa aag atg ggt gga gat gag ttc tgc cgt cgt     1008
 Gln Phe Arg Ser Val Lys Lys Met Gly Gly Asp Glu Phe Cys Arg Arg
                 325                 330                 335

 tat cag gac cag ctt gaa gct gaa att gaa gaa acc tat gca aat ttt     1056
 Tyr Gln Asp Gln Leu Glu Ala Glu Ile Glu Glu Thr Tyr Ala Asn Phe
             340                 345                 350

 ata aag cac aat gat ggc aaa aat atc ttc tat gct gct cgt acc cca     1104
 Ile Lys His Asn Asp Gly Lys Asn Ile Phe Tyr Ala Ala Arg Thr Pro
         355                 360                 365

 gcc aca ctg ttt gcg gtc atg ttt gct atg tat ata atc tca gga ctg     1152
 Ala Thr Leu Phe Ala Val Met Phe Ala Met Tyr Ile Ile Ser Gly Leu
     370                 375                 380

 act ggc ttc att ggc cta aac tct ata gct gtc ttg tgt aac ctt gtc     1200
 Thr Gly Phe Ile Gly Leu Asn Ser Ile Ala Val Leu Cys Asn Leu Val
 385                 390                 395                 400

 atg ggg tta gca ctg ata ttt ctt tgt act tgg gca tat gtt aaa tac     1248
 Met Gly Leu Ala Leu Ile Phe Leu Cys Thr Trp Ala Tyr Val Lys Tyr
                 405                 410                 415

 tct ggg gag ttc aga gaa att gga aca gtg att gat cag att gct gaa     1296
 Ser Gly Glu Phe Arg Glu Ile Gly Thr Val Ile Asp Gln Ile Ala Glu
             420                 425                 430

 aca cta tgg gaa cag gtg ttt tcc aaa ctg ttt gaa gtt act aga cgt     1344
 Thr Leu Trp Glu Gln Val Phe Ser Lys Leu Phe Glu Val Thr Arg Arg
         435                 440                 445

 cga atg gtt cac cgt gct ctt tca tca gca cag cga cag aga ctg tca     1392
 Arg Met Val His Arg Ala Leu Ser Ser Ala Gln Arg Gln Arg Leu Ser
     450                 455                 460

 tcc aac aat aac aag aag aaa aat tag                                 1419
 Ser Asn Asn Asn Lys Lys Lys Asn 
 465                 470





      <210> 829
      <211> 618
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (1)..(618)

      <400> 829
  atg agg gca ggg ctg gtc ttg gca gtg aca ctg agt ttg gtg tta ttg      48
  Met Arg Ala Gly Leu Val Leu Ala Val Thr Leu Ser Leu Val Leu Leu
    1               5                  10                  15

 ggc tct ctg tct tgg cag aaa tgc atc aag gat ggc aac tgg agt atc       96
 Gly Ser Leu Ser Trp Gln Lys Cys Ile Lys Asp Gly Asn Trp Ser Ile
              20                  25                  30

 ttc gtg tcc tct ccc ctg cta cac cag tgc cac ctt agt tat tca gaa      144
 Phe Val Ser Ser Pro Leu Leu His Gln Cys His Leu Ser Tyr Ser Glu
          35                  40                  45

 ctg aag aat gcc cac tct ctg ggc aga gct gtg ctc ttc cct gcc gcc      192
 Leu Lys Asn Ala His Ser Leu Gly Arg Ala Val Leu Phe Pro Ala Ala
      50                  55                  60

 cac cgg cca aag agg tcc tca tca ctg cca ttg aac cca gtc ctg cag      240
 His Arg Pro Lys Arg Ser Ser Ser Leu Pro Leu Asn Pro Val Leu Gln
  65                  70                  75                  80

 acc tcc ctg gag gag gtg gag ctg ctc tac gag ttc ctg ctg gcc gaa      288
 Thr Ser Leu Glu Glu Val Glu Leu Leu Tyr Glu Phe Leu Leu Ala Glu
                  85                  90                  95

 ctt gag atc agc cct gac ctg cag atc tcc atc aag gac gag gag ctg      336
 Leu Glu Ile Ser Pro Asp Leu Gln Ile Ser Ile Lys Asp Glu Glu Leu
             100                 105                 110

 gcc tcc ttg cgg aag gcc tca gac ttc cgc acc gtc tgc aac aac gtc      384
 Ala Ser Leu Arg Lys Ala Ser Asp Phe Arg Thr Val Cys Asn Asn Val
         115                 120                 125

 atc ccc aag agc atc cca gac atc cgc cgg ctc agc gcc agc ctc tcc      432
 Ile Pro Lys Ser Ile Pro Asp Ile Arg Arg Leu Ser Ala Ser Leu Ser
     130                 135                 140

 agc cac cct ggc atc ctc aag aaa gaa gac ttt gaa agg aca gtg ctg      480
 Ser His Pro Gly Ile Leu Lys Lys Glu Asp Phe Glu Arg Thr Val Leu
 145                 150                 155                 160

 acc ctg gcc tac aca gcc tac cgc aca gcc ctg tcc cac ggc cat cag      528
 Thr Leu Ala Tyr Thr Ala Tyr Arg Thr Ala Leu Ser His Gly His Gln
                 165                 170                 175

 aag gac atc tgg gcg cag tcc ctc gtt agc ctc ttc cag gcc ctg agg      576
 Lys Asp Ile Trp Ala Gln Ser Leu Val Ser Leu Phe Gln Ala Leu Arg
             180                 185                 190

 cac gac ttg atg cgc tcc tca cag ccg gga gta cct ccc tga              618
 His Asp Leu Met Arg Ser Ser Gln Pro Gly Val Pro Pro 
         195                 200                 205





      <210> 830
      <211> 1509
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (1)..(1509)

      <400> 830
  atg atg ttt acc ttc aga ttc atc acc acc ctt ctg gtt cac att ttc      48
  Met Met Phe Thr Phe Arg Phe Ile Thr Thr Leu Leu Val His Ile Phe
    1               5                  10                  15

 att tca ttg gtt att ttg gga ttg ttg ttt gtc tgc ggt gtt tta tgg       96
 Ile Ser Leu Val Ile Leu Gly Leu Leu Phe Val Cys Gly Val Leu Trp
              20                  25                  30

 tgg ctg tat tat gac tat acc aac gac ctc agc ata gaa ttg gac aca      144
 Trp Leu Tyr Tyr Asp Tyr Thr Asn Asp Leu Ser Ile Glu Leu Asp Thr
          35                  40                  45

 gaa agg gaa aat atg aag tgc gtg ctg ggg ttt gct atc gta tcc aca      192
 Glu Arg Glu Asn Met Lys Cys Val Leu Gly Phe Ala Ile Val Ser Thr
      50                  55                  60

 ggc atc acg gca gtg ctg ctc gtc ttg att ttt gtt ctc aga aag aga      240
 Gly Ile Thr Ala Val Leu Leu Val Leu Ile Phe Val Leu Arg Lys Arg
  65                  70                  75                  80

 ata aaa ttg aca gtt gag ctt ttc caa atc aca aat aaa gcc atc agc      288
 Ile Lys Leu Thr Val Glu Leu Phe Gln Ile Thr Asn Lys Ala Ile Ser
                  85                  90                  95

 agt gct ccc ttc ctg ctg ttc cag cca ctg tgg aca ttt gcc atc ctc      336
 Ser Ala Pro Phe Leu Leu Phe Gln Pro Leu Trp Thr Phe Ala Ile Leu
             100                 105                 110

 att ttc ttc tgg gtc ctc tgg gtg gct gtg ctg ctg agc ctg gga act      384
 Ile Phe Phe Trp Val Leu Trp Val Ala Val Leu Leu Ser Leu Gly Thr
         115                 120                 125

 gca gag tgg ttc tca gag tcc act gac ctc atc tac cta aca ggc att      432
 Ala Glu Trp Phe Ser Glu Ser Thr Asp Leu Ile Tyr Leu Thr Gly Ile
     130                 135                 140

 ctg ttt cgg agg ggc cac ctc ctc tgg aat tgg gaa tgt ttc ctg aag      480
 Leu Phe Arg Arg Gly His Leu Leu Trp Asn Trp Glu Cys Phe Leu Lys
 145                 150                 155                 160

 cat gcc ctg aat cac ccc atc tta gaa aac cat agg cat tta tcc atg      528
 His Ala Leu Asn His Pro Ile Leu Glu Asn His Arg His Leu Ser Met
                 165                 170                 175

 cct tac cca aaa cag aga ttg cct cca agc caa aga gct gcc cag gtt      576
 Pro Tyr Pro Lys Gln Arg Leu Pro Pro Ser Gln Arg Ala Ala Gln Val
             180                 185                 190

 atg gaa ggc ggc caa gtg gaa tat aag ccc ctt tcg ggc att cgg tac      624
 Met Glu Gly Gly Gln Val Glu Tyr Lys Pro Leu Ser Gly Ile Arg Tyr
         195                 200                 205

 atg tgg tcg tac cat tta att ggc ctc atc tgg act agt gaa ttc atc      672
 Met Trp Ser Tyr His Leu Ile Gly Leu Ile Trp Thr Ser Glu Phe Ile
     210                 215                 220

 ctt gcg tgc cag caa atg act ata gct ggg gca gtg gtt act tgt tat      720
 Leu Ala Cys Gln Gln Met Thr Ile Ala Gly Ala Val Val Thr Cys Tyr
 225                 230                 235                 240

 ttc aac aga agt aaa aat gat cct cct gat cat ccc atc ctt tcg tct      768
 Phe Asn Arg Ser Lys Asn Asp Pro Pro Asp His Pro Ile Leu Ser Ser
                 245                 250                 255

 ctc tcc att ctc ttc ttc tac cat caa gga acc att gtg aaa ggg tca      816
 Leu Ser Ile Leu Phe Phe Tyr His Gln Gly Thr Ile Val Lys Gly Ser
             260                 265                 270

 ttt tta atc tct gtg gtg agg att ccg aga atc att gtc atg tac atg      864
 Phe Leu Ile Ser Val Val Arg Ile Pro Arg Ile Ile Val Met Tyr Met
         275                 280                 285

 caa aac gca ctg aaa gaa cag aat gca tat act aca act gct att aat      912
 Gln Asn Ala Leu Lys Glu Gln Asn Ala Tyr Thr Thr Thr Ala Ile Asn
     290                 295                 300

 ggg aca gat ttc tgt aca tca gca aaa gat gca ttc aaa atc ttg tcc      960
 Gly Thr Asp Phe Cys Thr Ser Ala Lys Asp Ala Phe Lys Ile Leu Ser
 305                 310                 315                 320

 aag aac tca agt cac ttt aca tct att aac tgc ttt gga gac ttc ata     1008
 Lys Asn Ser Ser His Phe Thr Ser Ile Asn Cys Phe Gly Asp Phe Ile
                 325                 330                 335

 att ttt cta gga aag gtg tta gtg gtg tgt ttc act gtt ttt gga gga     1056
 Ile Phe Leu Gly Lys Val Leu Val Val Cys Phe Thr Val Phe Gly Gly
             340                 345                 350

 ctc atg gct ttt aac tac aat cgg gca ttc cag gtg tgg gca gtc cct     1104
 Leu Met Ala Phe Asn Tyr Asn Arg Ala Phe Gln Val Trp Ala Val Pro
         355                 360                 365

 ctg tta ttg gta gct ttt ttt gcc tac tta gta gcc cat agt ttt tta     1152
 Leu Leu Leu Val Ala Phe Phe Ala Tyr Leu Val Ala His Ser Phe Leu
     370                 375                 380

 tct gtg ttt gaa act gtg ctg gat gca ctt ttc ctg tgt ttt gct gtt     1200
 Ser Val Phe Glu Thr Val Leu Asp Ala Leu Phe Leu Cys Phe Ala Val
 385                 390                 395                 400

 gat ctg gaa aca aat gat gga tcg tca gaa aag ccc tac ttt atg gat     1248
 Asp Leu Glu Thr Asn Asp Gly Ser Ser Glu Lys Pro Tyr Phe Met Asp
                 405                 410                 415

 caa gaa ttt ctg gta agc aaa cat ttc att tcc agt tgc aat ctc cat     1296
 Gln Glu Phe Leu Val Ser Lys His Phe Ile Ser Ser Cys Asn Leu His
             420                 425                 430

 gct cgc aat ctt gaa agt ttt gta aag ctg cac aca cga aag agg ctc     1344
 Ala Arg Asn Leu Glu Ser Phe Val Lys Leu His Thr Arg Lys Arg Leu
         435                 440                 445

 ata ccc agc ctc tct ctt cta gag ggc tct gag gct tct act acc ccc     1392
 Ile Pro Ser Leu Ser Leu Leu Glu Gly Ser Glu Ala Ser Thr Thr Pro
     450                 455                 460

 ggg cct gaa agt ggg att tgc gct gaa ctc tcc aag gct gaa ccc acc     1440
 Gly Pro Glu Ser Gly Ile Cys Ala Glu Leu Ser Lys Ala Glu Pro Thr
 465                 470                 475                 480

 tcc ctt tct gag aac ctt ctc cct gaa gaa gtg aag ctg aac aag aat     1488
 Ser Leu Ser Glu Asn Leu Leu Pro Glu Glu Val Lys Leu Asn Lys Asn
                 485                 490                 495

 gct gat cag atg gat tcc taa                                         1509
 Ala Asp Gln Met Asp Ser 
             500





      <210> 831
      <211> 2214
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (1)..(2214)

      <400> 831
  atg tgg gag tcg agt ctg cac ctg aag ctg ggc ccc tgc ctg gcc gtg      48
  Met Trp Glu Ser Ser Leu His Leu Lys Leu Gly Pro Cys Leu Ala Val
    1               5                  10                  15

 cgc agc cca ctc tgg acc tgc acc ctg ggt gac ggt gaa cac tgc agc       96
 Arg Ser Pro Leu Trp Thr Cys Thr Leu Gly Asp Gly Glu His Cys Ser
              20                  25                  30

 ctg gca gct gtg tcc agg gtg tgc cct gcc ccc tac ctg ggc agc cac      144
 Leu Ala Ala Val Ser Arg Val Cys Pro Ala Pro Tyr Leu Gly Ser His
          35                  40                  45

 gtg act gtg tgc cct gtg gtg gtc agc agg gcc tct ctt ggc aca acc      192
 Val Thr Val Cys Pro Val Val Val Ser Arg Ala Ser Leu Gly Thr Thr
      50                  55                  60

 gcc cca gcc cgg ctg acg cag cgg cat ttg gaa atg cag aca cgc gat      240
 Ala Pro Ala Arg Leu Thr Gln Arg His Leu Glu Met Gln Thr Arg Asp
  65                  70                  75                  80

 aag cgt gcg cac ctg gcc tca gat tcc ctg ccg aaa act cca ggg gca      288
 Lys Arg Ala His Leu Ala Ser Asp Ser Leu Pro Lys Thr Pro Gly Ala
                  85                  90                  95

 gag ggg agc cgg act gct ccc aaa ggg gcc ctg agg aca gag ttg gcc      336
 Glu Gly Ser Arg Thr Ala Pro Lys Gly Ala Leu Arg Thr Glu Leu Ala
             100                 105                 110

 atg gcg acc gag agt gtc tgg atg ctt gag ttc tca gcc atc att ccc      384
 Met Ala Thr Glu Ser Val Trp Met Leu Glu Phe Ser Ala Ile Ile Pro
         115                 120                 125

 aag gct gca ctc tgc gcc atc act gtg aca cag cag aca gag gcc gct      432
 Lys Ala Ala Leu Cys Ala Ile Thr Val Thr Gln Gln Thr Glu Ala Ala
     130                 135                 140

 cta ctt aaa act ctc aac tct tct gta aat tac ctc tat ggc tct ctc      480
 Leu Leu Lys Thr Leu Asn Ser Ser Val Asn Tyr Leu Tyr Gly Ser Leu
 145                 150                 155                 160

 cac aag gaa gtc cca gct gct gct ttc acc caa tac caa gtg cag gga      528
 His Lys Glu Val Pro Ala Ala Ala Phe Thr Gln Tyr Gln Val Gln Gly
                 165                 170                 175

 cac aaa tcg cag ggc atg cag aag gaa tcg tta cgc ttc agg aac att      576
 His Lys Ser Gln Gly Met Gln Lys Glu Ser Leu Arg Phe Arg Asn Ile
             180                 185                 190

 gct tca gcc ctc gat gac ctc gat gcc att gtg gct aag gta cag ctc      624
 Ala Ser Ala Leu Asp Asp Leu Asp Ala Ile Val Ala Lys Val Gln Leu
         195                 200                 205

 ccg cag gtt cac cag gtt ctg cag acc ctc gat ctt ggt cag ccg gtt      672
 Pro Gln Val His Gln Val Leu Gln Thr Leu Asp Leu Gly Gln Pro Val
     210                 215                 220

 gct ctg caa gag gga gag cac aca gct gtc aga aca gta cag aag tac      720
 Ala Leu Gln Glu Gly Glu His Thr Ala Val Arg Thr Val Gln Lys Tyr
 225                 230                 235                 240

 ctc aaa tcc ttc aat ctt ccc tat gcg ata gtg att caa atc aac atc      768
 Leu Lys Ser Phe Asn Leu Pro Tyr Ala Ile Val Ile Gln Ile Asn Ile
                 245                 250                 255

 ctg aaa caa agc aga aat cta tac tca gct ata gca aag tgg ctg gag      816
 Leu Lys Gln Ser Arg Asn Leu Tyr Ser Ala Ile Ala Lys Trp Leu Glu
             260                 265                 270

 acc tgt gtc gtc cta gaa gag gcg gcc tgg aag tgg gca gca gtg ggg      864
 Thr Cys Val Val Leu Glu Glu Ala Ala Trp Lys Trp Ala Ala Val Gly
         275                 280                 285

 gag gca gtg cca gaa gac aga tgg agc tcc tat tgt cta tca tca ctg      912
 Glu Ala Val Pro Glu Asp Arg Trp Ser Ser Tyr Cys Leu Ser Ser Leu
     290                 295                 300

 gct gcc cag aat att tgt aca agt aaa ctg cac tgc cct gct gcc cct      960
 Ala Ala Gln Asn Ile Cys Thr Ser Lys Leu His Cys Pro Ala Ala Pro
 305                 310                 315                 320

 gag cac acg gac ccg tcc gaa ccg cgg ggc agt gtg tcc tgc tgc tcc     1008
 Glu His Thr Asp Pro Ser Glu Pro Arg Gly Ser Val Ser Cys Cys Ser
                 325                 330                 335

 ctg ctg cgg gga ctg tcc tca ggg tgg tcc tca cct ctg ctt ccg gcc     1056
 Leu Leu Arg Gly Leu Ser Ser Gly Trp Ser Ser Pro Leu Leu Pro Ala
             340                 345                 350

 cct gtg tgc aac cct aac aag gcc atc ttc acg gtg gat gcc aag acc     1104
 Pro Val Cys Asn Pro Asn Lys Ala Ile Phe Thr Val Asp Ala Lys Thr
         355                 360                 365

 aca gag atc ctg gtt gct aac gac aaa gct tgc ggg ctc ctg ggg tac     1152
 Thr Glu Ile Leu Val Ala Asn Asp Lys Ala Cys Gly Leu Leu Gly Tyr
     370                 375                 380

 agc agc cag gac ctg att ggc cag aag ctc acg cag ttc ttt ctg agg     1200
 Ser Ser Gln Asp Leu Ile Gly Gln Lys Leu Thr Gln Phe Phe Leu Arg
 385                 390                 395                 400

 tca gat tct gat gtg gtg gag gcc ctc agc gag gag cac atg gag gcc     1248
 Ser Asp Ser Asp Val Val Glu Ala Leu Ser Glu Glu His Met Glu Ala
                 405                 410                 415

 gac ggc cac gct gcg gtg gtg ttt ggc acg gtg gtg gac atc atc agc     1296
 Asp Gly His Ala Ala Val Val Phe Gly Thr Val Val Asp Ile Ile Ser
             420                 425                 430

 cgt agt ggg gag aag att cca gtg tct gtg tgg atg aag agg atg cgg     1344
 Arg Ser Gly Glu Lys Ile Pro Val Ser Val Trp Met Lys Arg Met Arg
         435                 440                 445

 cag gag cgc cgc cta tgc tgc gtg gtg gtc ctg gag ccc gtg gag agg     1392
 Gln Glu Arg Arg Leu Cys Cys Val Val Val Leu Glu Pro Val Glu Arg
     450                 455                 460

 gtc tcg acc tgg gtc gct ttc cag agc gat ggc acc gtc acg tca tgt     1440
 Val Ser Thr Trp Val Ala Phe Gln Ser Asp Gly Thr Val Thr Ser Cys
 465                 470                 475                 480

 gac agt ctc ttt gct cat ctt cac ggg tac gtg tct ggg gag gac gtg     1488
 Asp Ser Leu Phe Ala His Leu His Gly Tyr Val Ser Gly Glu Asp Val
                 485                 490                 495

 gct ggg cag cat atc aca gac ctg atc cct tct gtg cag ctc cct cct     1536
 Ala Gly Gln His Ile Thr Asp Leu Ile Pro Ser Val Gln Leu Pro Pro
             500                 505                 510

 tct ggc cag cac atc cca aag aat ctc aag att cag agg tct gtt gga     1584
 Ser Gly Gln His Ile Pro Lys Asn Leu Lys Ile Gln Arg Ser Val Gly
         515                 520                 525

 aga gcc agg gac ggt acc acc ttc cct ctg agc tta aag ctg aaa tcc     1632
 Arg Ala Arg Asp Gly Thr Thr Phe Pro Leu Ser Leu Lys Leu Lys Ser
     530                 535                 540

 caa ccc agc agc gag gag gcg acc acc ggt gag gcg gcc cct gtg agc     1680
 Gln Pro Ser Ser Glu Glu Ala Thr Thr Gly Glu Ala Ala Pro Val Ser
 545                 550                 555                 560

 ggc tac cgg gca tct gtc tgg gtg ttc tgc acc atc agt ggc ctc atc     1728
 Gly Tyr Arg Ala Ser Val Trp Val Phe Cys Thr Ile Ser Gly Leu Ile
                 565                 570                 575

 acc ctc ctg ccg gat ggg acc atc cac ggc atc aac cac agc ttc gcg     1776
 Thr Leu Leu Pro Asp Gly Thr Ile His Gly Ile Asn His Ser Phe Ala
             580                 585                 590

 ctg aca ctg ttt ggt tac gga aag acg gag ctc ctg ggc aag aat atc     1824
 Leu Thr Leu Phe Gly Tyr Gly Lys Thr Glu Leu Leu Gly Lys Asn Ile
         595                 600                 605

 act ttc ctg att cct ggt ttc tac agc tac atg gac ctt gcg tac aac     1872
 Thr Phe Leu Ile Pro Gly Phe Tyr Ser Tyr Met Asp Leu Ala Tyr Asn
     610                 615                 620

 agc tca tta cag ctc cca gac ctg gcc agc tgc ctg gac gtc ggc aat     1920
 Ser Ser Leu Gln Leu Pro Asp Leu Ala Ser Cys Leu Asp Val Gly Asn
 625                 630                 635                 640

 gag agt ggg tgt ggg gag aga acc ttg gac ccg tgg cag ggc cag gac     1968
 Glu Ser Gly Cys Gly Glu Arg Thr Leu Asp Pro Trp Gln Gly Gln Asp
                 645                 650                 655

 cca gct gag ggg ggc cag gat cca agg att aat gtc gtg ctt gct ggt     2016
 Pro Ala Glu Gly Gly Gln Asp Pro Arg Ile Asn Val Val Leu Ala Gly
             660                 665                 670

 ggc cac gtt gtg ccc cga gat gag atc cgg aag ctg atg gaa agc caa     2064
 Gly His Val Val Pro Arg Asp Glu Ile Arg Lys Leu Met Glu Ser Gln
         675                 680                 685

 gac atc ttc acc ggg act cag act gag ctg att gct gga ggc cag ctc     2112
 Asp Ile Phe Thr Gly Thr Gln Thr Glu Leu Ile Ala Gly Gly Gln Leu
     690                 695                 700

 ctt tcc tgc ctc tca cct cag cct gct cca ggg gat aag gaa aca ggc     2160
 Leu Ser Cys Leu Ser Pro Gln Pro Ala Pro Gly Asp Lys Glu Thr Gly
 705                 710                 715                 720

 tgt gga gag ttc cag aat gtt gag gta gat ttc aga gaa ctg atg gaa     2208
 Cys Gly Glu Phe Gln Asn Val Glu Val Asp Phe Arg Glu Leu Met Glu
                 725                 730                 735

 tca taa                                                             2214
 Ser 






      <210> 832
      <211> 858
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (1)..(858)

      <400> 832
  atg gac atc ccc atc agc agc aga gac ttc cgc ggc ctg cag ctg gcc      48
  Met Asp Ile Pro Ile Ser Ser Arg Asp Phe Arg Gly Leu Gln Leu Ala
    1               5                  10                  15

 tgc gtg gct ctc ggg ctg gtg gct ggc agc atc att atc ggc atc tcc       96
 Cys Val Ala Leu Gly Leu Val Ala Gly Ser Ile Ile Ile Gly Ile Ser
              20                  25                  30

 gta tcc aag gct gca gct gcc atg ggc ggt gtc ttt att ggc gct gct      144
 Val Ser Lys Ala Ala Ala Ala Met Gly Gly Val Phe Ile Gly Ala Ala
          35                  40                  45

 gtt ctg ggg ctc ctc atc ttg gcc tac ccc ttc ctg aag gct cgg ttc      192
 Val Leu Gly Leu Leu Ile Leu Ala Tyr Pro Phe Leu Lys Ala Arg Phe
      50                  55                  60

 aac ctg gac cac atc ctg cct acc ata ggg gca gac cac ggg gaa gga      240
 Asn Leu Asp His Ile Leu Pro Thr Ile Gly Ala Asp His Gly Glu Gly
  65                  70                  75                  80

 aga tcc agc acc aat ggc aac aag gaa gga gta gtc aat gtg gag aca      288
 Arg Ser Ser Thr Asn Gly Asn Lys Glu Gly Val Val Asn Val Glu Thr
                  85                  90                  95

 tgt ggc ttc tcc ccc tca cac ttc gag aaa agg ccg atg ccg ccg gca      336
 Cys Gly Phe Ser Pro Ser His Phe Glu Lys Arg Pro Met Pro Pro Ala
             100                 105                 110

 gaa aag agc gag ggg cca ccg gtc ccg gcg ccc gcg gaa cgc gcc cgg      384
 Glu Lys Ser Glu Gly Pro Pro Val Pro Ala Pro Ala Glu Arg Ala Arg
         115                 120                 125

 ggc cgg gtg ccc ggc ctg ccg tcg ccg gcg ctg tgc tgc gcc tgc ggt      432
 Gly Arg Val Pro Gly Leu Pro Ser Pro Ala Leu Cys Cys Ala Cys Gly
     130                 135                 140

 ctg tgc gcg ctg ctg gcg ggc gtg aac gtg acg ctg gca ggc gcc ttc      480
 Leu Cys Ala Leu Leu Ala Gly Val Asn Val Thr Leu Ala Gly Ala Phe
 145                 150                 155                 160

 gcc tcc ttc ttg ccc gag cac aac gcg ctg ctc gtc gtg ggg ctg gcg      528
 Ala Ser Phe Leu Pro Glu His Asn Ala Leu Leu Val Val Gly Leu Ala
                 165                 170                 175

 ctg ctg gtg ctg gcg ctc ggc ttc ttc gcg gcc tgc tgc gtg tgt agc      576
 Leu Leu Val Leu Ala Leu Gly Phe Phe Ala Ala Cys Cys Val Cys Ser
             180                 185                 190

 cgc cgg ggc ctc gcg ccc cgt ggg cgc tcg gcg gcc gcg gcg ggc ccg      624
 Arg Arg Gly Leu Ala Pro Arg Gly Arg Ser Ala Ala Ala Ala Gly Pro
         195                 200                 205

 ggc cag ggt ggc ggc cgc gcc ggg ccc gtg gcg ctg gag atg gag agc      672
 Gly Gln Gly Gly Gly Arg Ala Gly Pro Val Ala Leu Glu Met Glu Ser
     210                 215                 220

 agc gag ccc acg gca cag gac acc acg gcc gtg cag ctc agc cct gcc      720
 Ser Glu Pro Thr Ala Gln Asp Thr Thr Ala Val Gln Leu Ser Pro Ala
 225                 230                 235                 240

 gtc tcc gcc gcg tcc tcc ggc tgc tcc agc ccc ggc ccc agc ccc ctc      768
 Val Ser Ala Ala Ser Ser Gly Cys Ser Ser Pro Gly Pro Ser Pro Leu
                 245                 250                 255

 gcc ctg gag gcc ccg gcg ccc gcg gcc gtc tgc gcg ctg cgc tcg gaa      816
 Ala Leu Glu Ala Pro Ala Pro Ala Ala Val Cys Ala Leu Arg Ser Glu
             260                 265                 270

 gga gtc cag ctc aac cca ccc cgg gcg cgc gcc gcc ccc tag              858
 Gly Val Gln Leu Asn Pro Pro Arg Ala Arg Ala Ala Pro 
         275                 280                 285





      <210> 833
      <211> 2352
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (1)..(2352)

      <400> 833
  atg gct ctg gtt gaa atc gga gca gcc agc ctc tgt ctc ggg gcc atc      48
  Met Ala Leu Val Glu Ile Gly Ala Ala Ser Leu Cys Leu Gly Ala Ile
    1               5                  10                  15

 ctg agg ctg gaa gct gga tgc tgc act gag cgc ctg gtt ggt gtc act       96
 Leu Arg Leu Glu Ala Gly Cys Cys Thr Glu Arg Leu Val Gly Val Thr
              20                  25                  30

 ggc ggt gac gag ggc aag cct ggg cca ctt cct gtt tcc agt ctc ctt      144
 Gly Gly Asp Glu Gly Lys Pro Gly Pro Leu Pro Val Ser Ser Leu Leu
          35                  40                  45

 ctt gaa aag tgg act ttt ccc aaa agt ggg aga agt cga agc aga gtt      192
 Leu Glu Lys Trp Thr Phe Pro Lys Ser Gly Arg Ser Arg Ser Arg Val
      50                  55                  60

 gct tgc ttt gtg tta gtg tgg tat gac ctg gat tca ctg gag cag ttt      240
 Ala Cys Phe Val Leu Val Trp Tyr Asp Leu Asp Ser Leu Glu Gln Phe
  65                  70                  75                  80

 ccc gtc ccc ttg ggt tac gat aac aac atc acc cct ttc cag aag ttg      288
 Pro Val Pro Leu Gly Tyr Asp Asn Asn Ile Thr Pro Phe Gln Lys Leu
                  85                  90                  95

 ctt att ttg cgc tgt ttc cgt gtg gat cgg gtc tat cgg gcc gtg act      336
 Leu Ile Leu Arg Cys Phe Arg Val Asp Arg Val Tyr Arg Ala Val Thr
             100                 105                 110

 gac tat gtg act gta aca atg gga gag aag tat gtg cag ccc cca atg      384
 Asp Tyr Val Thr Val Thr Met Gly Glu Lys Tyr Val Gln Pro Pro Met
         115                 120                 125

 atc agc ttt gaa gct att ttt gag cag agc act cca cat tcg ccc att      432
 Ile Ser Phe Glu Ala Ile Phe Glu Gln Ser Thr Pro His Ser Pro Ile
     130                 135                 140

 gtg ttt atc ctg agt cct ggc tcc gac cct gcc act gat ctt atg aaa      480
 Val Phe Ile Leu Ser Pro Gly Ser Asp Pro Ala Thr Asp Leu Met Lys
 145                 150                 155                 160

 tta gca gag cga agt ggt ttt gga gga aat cgc ctc aaa ttc ctt gca      528
 Leu Ala Glu Arg Ser Gly Phe Gly Gly Asn Arg Leu Lys Phe Leu Ala
                 165                 170                 175

 atg ggt caa ggt caa gaa aag gct ggg tgt gac cag ctc agt gca ccc      576
 Met Gly Gln Gly Gln Glu Lys Ala Gly Cys Asp Gln Leu Ser Ala Pro
             180                 185                 190

 acg ggg ccc atg ggg ttt ctc aaa gat ggt tta ttt gaa ggc tcc acc      624
 Thr Gly Pro Met Gly Phe Leu Lys Asp Gly Leu Phe Glu Gly Ser Thr
         195                 200                 205

 tgt agc tcc tgg atc ctc ggc ttg ctt ttg gct tct gct gga gct gcc      672
 Cys Ser Ser Trp Ile Leu Gly Leu Leu Leu Ala Ser Ala Gly Ala Ala
     210                 215                 220

 atc gcc ctt ctg tgg gtg gcc ctg cag ctg ctg gag acg gcg gtg gct      720
 Ile Ala Leu Leu Trp Val Ala Leu Gln Leu Leu Glu Thr Ala Val Ala
 225                 230                 235                 240

 cgg ggg cag tgg ctg atg ctg cag aac tgc cac ctc ctg gtc aag tgg      768
 Arg Gly Gln Trp Leu Met Leu Gln Asn Cys His Leu Leu Val Lys Trp
                 245                 250                 255

 ctg aaa gat ctg gag aag tcc ctg gag agg atc acc aag ccc cac cca      816
 Leu Lys Asp Leu Glu Lys Ser Leu Glu Arg Ile Thr Lys Pro His Pro
             260                 265                 270

 gac ttc cgc ctg tgg ctc acc acg gac ccc acc aag ggc ttc ccc att      864
 Asp Phe Arg Leu Trp Leu Thr Thr Asp Pro Thr Lys Gly Phe Pro Ile
         275                 280                 285

 ggg att ctg cag aag tcc cta aag gtt gtc acc gag cca ccc aat ggg      912
 Gly Ile Leu Gln Lys Ser Leu Lys Val Val Thr Glu Pro Pro Asn Gly
     290                 295                 300

 ctg aaa ctc aac atg agg gca act tac ttc aag atc tct cac gaa atg      960
 Leu Lys Leu Asn Met Arg Ala Thr Tyr Phe Lys Ile Ser His Glu Met
 305                 310                 315                 320

 ctg gac cag tgc ccg cac cct gcc ttc aag ccg ctg gtc tac gtg ctg     1008
 Leu Asp Gln Cys Pro His Pro Ala Phe Lys Pro Leu Val Tyr Val Leu
                 325                 330                 335

 gcg ttc ttt cat gct gtg gtg cag gag aga agg aag ttt ggg aag att     1056
 Ala Phe Phe His Ala Val Val Gln Glu Arg Arg Lys Phe Gly Lys Ile
             340                 345                 350

 ggc tgg aac gtg tac tat gac ttc aat gag tct gac ttc cag gtc tgc     1104
 Gly Trp Asn Val Tyr Tyr Asp Phe Asn Glu Ser Asp Phe Gln Val Cys
         355                 360                 365

 atg gaa att ctg aac acg tac tta acg aaa gcc ttc cag caa cgg gac     1152
 Met Glu Ile Leu Asn Thr Tyr Leu Thr Lys Ala Phe Gln Gln Arg Asp
     370                 375                 380

 cca agg atc ccg tgg ggc agc ctc aag tac cta att gga gag gtc atg     1200
 Pro Arg Ile Pro Trp Gly Ser Leu Lys Tyr Leu Ile Gly Glu Val Met
 385                 390                 395                 400

 tat gga gga cgg gcc atc gac agc ttt gat cgc cgc atc ctg acc atc     1248
 Tyr Gly Gly Arg Ala Ile Asp Ser Phe Asp Arg Arg Ile Leu Thr Ile
                 405                 410                 415

 tac atg gat gag tac ctg ggg gac ttc att ttt gat act ttc cag cca     1296
 Tyr Met Asp Glu Tyr Leu Gly Asp Phe Ile Phe Asp Thr Phe Gln Pro
             420                 425                 430

 ttc cac ttc ttc cgg aac aag gaa gtg gac tac aaa atc cct gtt ggt     1344
 Phe His Phe Phe Arg Asn Lys Glu Val Asp Tyr Lys Ile Pro Val Gly
         435                 440                 445

 gat gaa aag gag aaa ttt gtt gaa gcc atc gag gcc ctc ccg ctt gcc     1392
 Asp Glu Lys Glu Lys Phe Val Glu Ala Ile Glu Ala Leu Pro Leu Ala
     450                 455                 460

 aac acg cca gaa gtg ttt ggt ctc cac ccc aac gct gag att ggc tat     1440
 Asn Thr Pro Glu Val Phe Gly Leu His Pro Asn Ala Glu Ile Gly Tyr
 465                 470                 475                 480

 tac acg cag gcg gct cga gac atg tgg gct cac ctg ctg gag ctg cag     1488
 Tyr Thr Gln Ala Ala Arg Asp Met Trp Ala His Leu Leu Glu Leu Gln
                 485                 490                 495

 cct cag aca ggg gaa tcc agc agt ggt atc agc cgc gat gat tat att     1536
 Pro Gln Thr Gly Glu Ser Ser Ser Gly Ile Ser Arg Asp Asp Tyr Ile
             500                 505                 510

 ggc caa gtg gcc aaa gaa ata gaa aac aag atg ccc aaa gtc ttt gac     1584
 Gly Gln Val Ala Lys Glu Ile Glu Asn Lys Met Pro Lys Val Phe Asp
         515                 520                 525

 ttg gac cag gtg agg aag cgc ctc gga aca gga ctc tcc ccc act tcg     1632
 Leu Asp Gln Val Arg Lys Arg Leu Gly Thr Gly Leu Ser Pro Thr Ser
     530                 535                 540

 gtg gtg ctc ctg cag gaa ctg gaa cgc ttc aac aag ctt gtg gtc cgg     1680
 Val Val Leu Leu Gln Glu Leu Glu Arg Phe Asn Lys Leu Val Val Arg
 545                 550                 555                 560

 atg acg aag tct ctg gct gaa ctt caa agg gcc ttg gct gga gaa gtt     1728
 Met Thr Lys Ser Leu Ala Glu Leu Gln Arg Ala Leu Ala Gly Glu Val
                 565                 570                 575

 gga atg agc aat gag tta gat gat gtg gcc agg tct ctt ttt atc ggg     1776
 Gly Met Ser Asn Glu Leu Asp Asp Val Ala Arg Ser Leu Phe Ile Gly
             580                 585                 590

 cat atc cct aat atc tgg aga agg ctt gct cct gac acc tta aag tcc     1824
 His Ile Pro Asn Ile Trp Arg Arg Leu Ala Pro Asp Thr Leu Lys Ser
         595                 600                 605

 ctt gga aac tgg atg gtc tac ttc ctg cgg cgg ttc agc cag tac atg     1872
 Leu Gly Asn Trp Met Val Tyr Phe Leu Arg Arg Phe Ser Gln Tyr Met
     610                 615                 620

 ttg tgg gtg acc gag agc gag ccc agc gtg atg tgg ctc tcg ggg ctg     1920
 Leu Trp Val Thr Glu Ser Glu Pro Ser Val Met Trp Leu Ser Gly Leu
 625                 630                 635                 640

 cac atc cct gag tcc tac ctc acg gcg ctg gtg cag gcc acc tgc cgg     1968
 His Ile Pro Glu Ser Tyr Leu Thr Ala Leu Val Gln Ala Thr Cys Arg
                 645                 650                 655

 aag aac ggc tgg cca ctg gac cgc tcc acc ttg ttc aca caa gtg acc     2016
 Lys Asn Gly Trp Pro Leu Asp Arg Ser Thr Leu Phe Thr Gln Val Thr
             660                 665                 670

 aag ttc cag gat gca gat gaa gtg aat gag cgg gcg gga caa gga tgc     2064
 Lys Phe Gln Asp Ala Asp Glu Val Asn Glu Arg Ala Gly Gln Gly Cys
         675                 680                 685

 ttt gtc tca gga ctg tac ctg gaa ggt gct gac tgg gat ata gaa aaa     2112
 Phe Val Ser Gly Leu Tyr Leu Glu Gly Ala Asp Trp Asp Ile Glu Lys
     690                 695                 700

 gga tgt ctt atc aag agc aaa ccc aag gtg ctg gtt gtg gac ctg ccg     2160
 Gly Cys Leu Ile Lys Ser Lys Pro Lys Val Leu Val Val Asp Leu Pro
 705                 710                 715                 720

 atc ctg aag atc atc ccc att gaa gcc cat cgc ctc aag ctg cag aat     2208
 Ile Leu Lys Ile Ile Pro Ile Glu Ala His Arg Leu Lys Leu Gln Asn
                 725                 730                 735

 act ttc cgg acc ccc gtc tac acc acc tcc atg aga agg aac gcc atg     2256
 Thr Phe Arg Thr Pro Val Tyr Thr Thr Ser Met Arg Arg Asn Ala Met
             740                 745                 750

 gga gtc ggc ttg gtt ttt gaa gct gat ctc ttt acc acg agg cac att     2304
 Gly Val Gly Leu Val Phe Glu Ala Asp Leu Phe Thr Thr Arg His Ile
         755                 760                 765

 tct cac tgg gtg ctg caa gga gta tgc ctc acc ctg aat tct gat taa     2352
 Ser His Trp Val Leu Gln Gly Val Cys Leu Thr Leu Asn Ser Asp 
     770                 775                 780





      <210> 834
      <211> 2346
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (1)..(2346)

      <400> 834
  atg cac ggc tcc tgc agt ttc ctg atg ctt ctg ctg ccg cta ctg cta      48
  Met His Gly Ser Cys Ser Phe Leu Met Leu Leu Leu Pro Leu Leu Leu
    1               5                  10                  15

 ctg ctg gtg gcc acc aca ggc ccc gtt gga gcc ctc aca gat gag gag       96
 Leu Leu Val Ala Thr Thr Gly Pro Val Gly Ala Leu Thr Asp Glu Glu
              20                  25                  30

 aaa cgt ttg atg gtg gag ctg cac aac ctc tac cgg gcc cag gta tcc      144
 Lys Arg Leu Met Val Glu Leu His Asn Leu Tyr Arg Ala Gln Val Ser
          35                  40                  45

 ccg acg gcc tca gac atg ctg cac atg aga tgg gac gag gag ctg gcc      192
 Pro Thr Ala Ser Asp Met Leu His Met Arg Trp Asp Glu Glu Leu Ala
      50                  55                  60

 gcc ttc gcc aag gcc tac gca cgg cag tgc gtg tgg ggc cac aac aag      240
 Ala Phe Ala Lys Ala Tyr Ala Arg Gln Cys Val Trp Gly His Asn Lys
  65                  70                  75                  80

 gag cgc ggg cgc cgc ggc gag aat ctg ttc gcc atc aca gac gag ggc      288
 Glu Arg Gly Arg Arg Gly Glu Asn Leu Phe Ala Ile Thr Asp Glu Gly
                  85                  90                  95

 atg gac gtg ccg ctg gcc atg gag gag tgg cac cac gag cgt gag cac      336
 Met Asp Val Pro Leu Ala Met Glu Glu Trp His His Glu Arg Glu His
             100                 105                 110

 tac aac ctc agc gcc gcc acc tgc agc cca ggc cag atg tgc ggc cac      384
 Tyr Asn Leu Ser Ala Ala Thr Cys Ser Pro Gly Gln Met Cys Gly His
         115                 120                 125

 tac acg cag gtg gta tgg gcc aag aca gag agg atc ggc tgt ggt tcc      432
 Tyr Thr Gln Val Val Trp Ala Lys Thr Glu Arg Ile Gly Cys Gly Ser
     130                 135                 140

 cac ttc tgt gag aag ctc cag ggt gtt gag gag acc aac atc gaa tta      480
 His Phe Cys Glu Lys Leu Gln Gly Val Glu Glu Thr Asn Ile Glu Leu
 145                 150                 155                 160

 ctg gtg tgc aac tat gag cct ccc atc ctc ctg acc tcc tgt agg ggg      528
 Leu Val Cys Asn Tyr Glu Pro Pro Ile Leu Leu Thr Ser Cys Arg Gly
                 165                 170                 175

 aac gtg aag ggg aaa cgg ccc tac cag gag ggg act ccg tgc tcc caa      576
 Asn Val Lys Gly Lys Arg Pro Tyr Gln Glu Gly Thr Pro Cys Ser Gln
             180                 185                 190

 tgt ccc tct ggc tac cac tgc aag aac tcc ctc tgt gca acg ggg att      624
 Cys Pro Ser Gly Tyr His Cys Lys Asn Ser Leu Cys Ala Thr Gly Ile
         195                 200                 205

 ccg gct ttc ttg gta aca gag gtc tca ggc tcc ctg gca acc aag gct      672
 Pro Ala Phe Leu Val Thr Glu Val Ser Gly Ser Leu Ala Thr Lys Ala
     210                 215                 220

 ctg cct gct gtg gaa acc cag gcc cca act tcc tta gca acg aaa gac      720
 Leu Pro Ala Val Glu Thr Gln Ala Pro Thr Ser Leu Ala Thr Lys Asp
 225                 230                 235                 240

 ccg ccc tcc atg gca aca gag gct cca cct tgc gta aca act gag gtc      768
 Pro Pro Ser Met Ala Thr Glu Ala Pro Pro Cys Val Thr Thr Glu Val
                 245                 250                 255

 cct tcc att ttg gca gct cac agc ctg ccc tcc ttg gat gag gag cca      816
 Pro Ser Ile Leu Ala Ala His Ser Leu Pro Ser Leu Asp Glu Glu Pro
             260                 265                 270

 gtt acc ttc ccc aaa tcg acc cat gtt cct atc cca aaa tca gca gac      864
 Val Thr Phe Pro Lys Ser Thr His Val Pro Ile Pro Lys Ser Ala Asp
         275                 280                 285

 aaa gtg aca gac aaa aca aaa gtg ccc tct agg agc cca gag aac tct      912
 Lys Val Thr Asp Lys Thr Lys Val Pro Ser Arg Ser Pro Glu Asn Ser
     290                 295                 300

 ctg gac ccc aag atg tcc ctg aca ggg gca agg gaa ctc cta ccc cat      960
 Leu Asp Pro Lys Met Ser Leu Thr Gly Ala Arg Glu Leu Leu Pro His
 305                 310                 315                 320

 gcc cag gag gag gct gag gct gag gct gag ttg cct cct tcc agt gag     1008
 Ala Gln Glu Glu Ala Glu Ala Glu Ala Glu Leu Pro Pro Ser Ser Glu
                 325                 330                 335

 gtc ttg gcc tca gtt ttt cca gcc cag gac aag cca ggt gag ctg cag     1056
 Val Leu Ala Ser Val Phe Pro Ala Gln Asp Lys Pro Gly Glu Leu Gln
             340                 345                 350

 gcc aca ctg gac cac acg ggg cac acc tcc tcc aag tcc ctg ccc aat     1104
 Ala Thr Leu Asp His Thr Gly His Thr Ser Ser Lys Ser Leu Pro Asn
         355                 360                 365

 ttc ccc aat acc tct gcc acc gct aat gcc acg ggt ggg cgt gcc ctg     1152
 Phe Pro Asn Thr Ser Ala Thr Ala Asn Ala Thr Gly Gly Arg Ala Leu
     370                 375                 380

 gct ctg cag tcg tcc ttg cca ggg caa agc atg atc ctg atg aca ccc     1200
 Ala Leu Gln Ser Ser Leu Pro Gly Gln Ser Met Ile Leu Met Thr Pro
 385                 390                 395                 400

 ggc gga aaa gca ggc tgg agc ctc gga aga gct ggc cct gga cca gaa     1248
 Gly Gly Lys Ala Gly Trp Ser Leu Gly Arg Ala Gly Pro Gly Pro Glu
                 405                 410                 415

 gga aaa gta agc ctc gag gcc act cag agt tct ggc tcc ctc cgg gcc     1296
 Gly Lys Val Ser Leu Glu Ala Thr Gln Ser Ser Gly Ser Leu Arg Ala
             420                 425                 430

 act gcc cca ttt cac tgc gag gca aat caa ggc cag gaa aag gca agg     1344
 Thr Ala Pro Phe His Cys Glu Ala Asn Gln Gly Gln Glu Lys Ala Arg
         435                 440                 445

 ttc tgc cct cgg cca aag cct gga ccc ctg act gct ggg ccc aag agc     1392
 Phe Cys Pro Arg Pro Lys Pro Gly Pro Leu Thr Ala Gly Pro Lys Ser
     450                 455                 460

 tcc agc tac gga gag gta gct tcg gta cag aac acg aga acc caa gat     1440
 Ser Ser Tyr Gly Glu Val Ala Ser Val Gln Asn Thr Arg Thr Gln Asp
 465                 470                 475                 480

 acc aag tat ctc ctc aca ata ttg aat tcc atg aaa cca ctt atc ttt     1488
 Thr Lys Tyr Leu Leu Thr Ile Leu Asn Ser Met Lys Pro Leu Ile Phe
                 485                 490                 495

 gca tgc aat gaa gca tcc aca aaa cca ttt cag ctg aag gat gta gca     1536
 Ala Cys Asn Glu Ala Ser Thr Lys Pro Phe Gln Leu Lys Asp Val Ala
             500                 505                 510

 aag aac agg aaa ggc ctc cgc cgt cca gtg ctt gct cac ctg cac act     1584
 Lys Asn Arg Lys Gly Leu Arg Arg Pro Val Leu Ala His Leu His Thr
         515                 520                 525

 cag gtg att ctg gca gac acg tcc cca ggc cct cct agc ctc ctg gga     1632
 Gln Val Ile Leu Ala Asp Thr Ser Pro Gly Pro Pro Ser Leu Leu Gly
     530                 535                 540

 ggg aaa gcc act tca aga agg aat gcc atc ctt ctt gaa ggt gat ccc     1680
 Gly Lys Ala Thr Ser Arg Arg Asn Ala Ile Leu Leu Glu Gly Asp Pro
 545                 550                 555                 560

 cac tgt gag aat gtc tgg aca ctg caa ttc cca gcc atc gct gct ccc     1728
 His Cys Glu Asn Val Trp Thr Leu Gln Phe Pro Ala Ile Ala Ala Pro
                 565                 570                 575

 tac ctc tta tct tgg ttc agg cag aac cag tca acc cct cag acc ctg     1776
 Tyr Leu Leu Ser Trp Phe Arg Gln Asn Gln Ser Thr Pro Gln Thr Leu
             580                 585                 590

 ggc atc agc agc aca cgg aaa gaa gga caa gtc ctt gtt cca acc aac     1824
 Gly Ile Ser Ser Thr Arg Lys Glu Gly Gln Val Leu Val Pro Thr Asn
         595                 600                 605

 ctg gga acc tgg att ctg gtc gtt tcc cag ccc ccc tgg ggt gtc act     1872
 Leu Gly Thr Trp Ile Leu Val Val Ser Gln Pro Pro Trp Gly Val Thr
     610                 615                 620

 cac gct gtc atc cac cag gta ggc att gat gaa gtg ggc cag cag gtt     1920
 His Ala Val Ile His Gln Val Gly Ile Asp Glu Val Gly Gln Gln Val
 625                 630                 635                 640

 aca gcc cca caa gaa aac cac atc gcc cag gag gga agt ctt cat atc     1968
 Thr Ala Pro Gln Glu Asn His Ile Ala Gln Glu Gly Ser Leu His Ile
                 645                 650                 655

 atc ctt gtt gga aac ctg ctc aat ctc atc tgg agg gaa aac ctg aaa     2016
 Ile Leu Val Gly Asn Leu Leu Asn Leu Ile Trp Arg Glu Asn Leu Lys
             660                 665                 670

 cag aga agg gaa aga acc aag ttc agc tac gcc tct tcc atg gaa ctc     2064
 Gln Arg Arg Glu Arg Thr Lys Phe Ser Tyr Ala Ser Ser Met Glu Leu
         675                 680                 685

 ttc ggg gac ttg ggc ggc agg aac cag ctc caa ata ttt cct ctg cag     2112
 Phe Gly Asp Leu Gly Gly Arg Asn Gln Leu Gln Ile Phe Pro Leu Gln
     690                 695                 700

 tgt cta ttg gct ggg ccc acc tca gac tct gca ctc aac aac aca ggg     2160
 Cys Leu Leu Ala Gly Pro Thr Ser Asp Ser Ala Leu Asn Asn Thr Gly
 705                 710                 715                 720

 aca aaa ctg gaa gag aaa tat gac acc caa ttc tgc caa cag cat gtg     2208
 Thr Lys Leu Glu Glu Lys Tyr Asp Thr Gln Phe Cys Gln Gln His Val
                 725                 730                 735

 aaa tgg aaa agg cac ctg tgt ctg tcc cct cct gct gtc tgg gct ggc     2256
 Lys Trp Lys Arg His Leu Cys Leu Ser Pro Pro Ala Val Trp Ala Gly
             740                 745                 750

 agc tgg cag cta cag gca gag gag ctg gac caa agc tgt atg gtt cac     2304
 Ser Trp Gln Leu Gln Ala Glu Glu Leu Asp Gln Ser Cys Met Val His
         755                 760                 765

 ctg ctc gca ccc cga cac cat gtc ctc tct gta cac gct tag             2346
 Leu Leu Ala Pro Arg His His Val Leu Ser Val His Ala 
     770                 775                 780





      <210> 835
      <211> 813
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (1)..(813)

      <400> 835
  atg ttg gac ttc gcg atc ttc gcc gtt acc ttc ttg ctg gcg ttg gtg      48
  Met Leu Asp Phe Ala Ile Phe Ala Val Thr Phe Leu Leu Ala Leu Val
    1               5                  10                  15

 gga gcc gtg ctc tac ctc tat ccg ggt atc ttt ttg agt gat tat ttt       96
 Gly Ala Val Leu Tyr Leu Tyr Pro Gly Ile Phe Leu Ser Asp Tyr Phe
              20                  25                  30

 gat aca gaa ata ttt aat ttg tct gtt tca gcg gac cct ttt gaa acc      144
 Asp Thr Glu Ile Phe Asn Leu Ser Val Ser Ala Asp Pro Phe Glu Thr
          35                  40                  45

 atg ctg aag tca tta tta agg tat caa tct ggt ggt ggc agt gtg agt      192
 Met Leu Lys Ser Leu Leu Arg Tyr Gln Ser Gly Gly Gly Ser Val Ser
      50                  55                  60

 gaa aac cac atg agg aaa aaa ttg tat gaa aat ggt gtg act gat tct      240
 Glu Asn His Met Arg Lys Lys Leu Tyr Glu Asn Gly Val Thr Asp Ser
  65                  70                  75                  80

 ctg aag agt aac ttt gcc ctc ctc cta aag ctt tca gaa gaa tta tta      288
 Leu Lys Ser Asn Phe Ala Leu Leu Leu Lys Leu Ser Glu Glu Leu Leu
                  85                  90                  95

 gat aaa tgg ctc tcc tac cca gag acc cag cac gtg ccc ctc agc cag      336
 Asp Lys Trp Leu Ser Tyr Pro Glu Thr Gln His Val Pro Leu Ser Gln
             100                 105                 110

 cat atg ctt ggt ttt gct atg aag tct gtt aca cag atg gta atg ggt      384
 His Met Leu Gly Phe Ala Met Lys Ser Val Thr Gln Met Val Met Gly
         115                 120                 125

 agt aca ttt gaa gat gat cag gaa gtc att cgc ttc cag aag aat cat      432
 Ser Thr Phe Glu Asp Asp Gln Glu Val Ile Arg Phe Gln Lys Asn His
     130                 135                 140

 ggc aca gtt tgg tct gag att gga aaa ggc ttt cta gat ggg tca ctt      480
 Gly Thr Val Trp Ser Glu Ile Gly Lys Gly Phe Leu Asp Gly Ser Leu
 145                 150                 155                 160

 gat aaa aac atg act cgg aaa aaa caa tat gaa gat ggt gtg gca gtg      528
 Asp Lys Asn Met Thr Arg Lys Lys Gln Tyr Glu Asp Gly Val Ala Val
                 165                 170                 175

 tgg ctt gtt gac aat act gcc aac ata cca ctg cat ttg tgg tat tgt      576
 Trp Leu Val Asp Asn Thr Ala Asn Ile Pro Leu His Leu Trp Tyr Cys
             180                 185                 190

 cag gcc agt gag att ctg aac ccc ttt gat gat gta tct ctt gtt tat      624
 Gln Ala Ser Glu Ile Leu Asn Pro Phe Asp Asp Val Ser Leu Val Tyr
         195                 200                 205

 tgt tgt agc tca gta tct agc aca gtg ctt cac atg cag cag acc ctc      672
 Cys Cys Ser Ser Val Ser Ser Thr Val Leu His Met Gln Gln Thr Leu
     210                 215                 220

 gtc ctt tat gcc ctt ggt gtg gta ctt cag gat cct aat act tgg cca      720
 Val Leu Tyr Ala Leu Gly Val Val Leu Gln Asp Pro Asn Thr Trp Pro
 225                 230                 235                 240

 tct cca cac aag tat gaa ata ttt gtc att gta ttt gtg act gtc agt      768
 Ser Pro His Lys Tyr Glu Ile Phe Val Ile Val Phe Val Thr Val Ser
                 245                 250                 255

 ttt tgt gtt tgc acg ttt tgc att cct ttc cta act gtt gag tag          813
 Phe Cys Val Cys Thr Phe Cys Ile Pro Phe Leu Thr Val Glu 
             260                 265                 270





      <210> 836
      <211> 558
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (1)..(558)

      <400> 836
  atg acg agg ata ctc atc gca acc ttc ctt ttc att tgc tgg gcc aca      48
  Met Thr Arg Ile Leu Ile Ala Thr Phe Leu Phe Ile Cys Trp Ala Thr
    1               5                  10                  15

 ctt cag tta cag gtg gtg acc aga gtg aat atc aag ttt aaa ctg cag       96
 Leu Gln Leu Gln Val Val Thr Arg Val Asn Ile Lys Phe Lys Leu Gln
              20                  25                  30

 gtg gca gca aat att cat gaa cta gac cca atg ctc ctc ccg ttc ttc      144
 Val Ala Ala Asn Ile His Glu Leu Asp Pro Met Leu Leu Pro Phe Phe
          35                  40                  45

 ctt gtg ttt gtt gtg ttt cga ttg ttg ttt tgg ttg ctt cct acc aaa      192
 Leu Val Phe Val Val Phe Arg Leu Leu Phe Trp Leu Leu Pro Thr Lys
      50                  55                  60

 aac ctg ggt ggg aaa cta aag gtg gga cag cca tac tgt aac gat gag      240
 Asn Leu Gly Gly Lys Leu Lys Val Gly Gln Pro Tyr Cys Asn Asp Glu
  65                  70                  75                  80

 acc acc agg aaa ata aac gca cat gtt aag cac tgc aga gta gaa aaa      288
 Thr Thr Arg Lys Ile Asn Ala His Val Lys His Cys Arg Val Glu Lys
                  85                  90                  95

 gga gcc tgg ggt gat gat ggc cca gaa gct aaa gat gag gat tca ggg      336
 Gly Ala Trp Gly Asp Asp Gly Pro Glu Ala Lys Asp Glu Asp Ser Gly
             100                 105                 110

 aaa cac tgg ctt gtt aca aag gag att gcg aag gat acg atg aag aga      384
 Lys His Trp Leu Val Thr Lys Glu Ile Ala Lys Asp Thr Met Lys Arg
         115                 120                 125

 tgc ata ggt aag aat aga cta atg cag aaa att ggt acc aaa gag tgg      432
 Cys Ile Gly Lys Asn Arg Leu Met Gln Lys Ile Gly Thr Lys Glu Trp
     130                 135                 140

 ggc gtt gct gta aat ata cct gaa aat gtg gaa gtg act ttg gaa cta      480
 Gly Val Ala Val Asn Ile Pro Glu Asn Val Glu Val Thr Leu Glu Leu
 145                 150                 155                 160

 ggt aac tgt cag aga ttg gaa gag tgt gaa gtg ctc aga aga aga cag      528
 Gly Asn Cys Gln Arg Leu Glu Glu Cys Glu Val Leu Arg Arg Arg Gln
                 165                 170                 175

 gaa aat gaa gga aag ttt gga act tcc tag                              558
 Glu Asn Glu Gly Lys Phe Gly Thr Ser 
             180                 185





      <210> 837
      <211> 1434
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (1)..(1434)

      <400> 837
  atg cag ctc cag gtg ttc tgg act ggg ctg gaa tac acc tgc cgg ctc      48
  Met Gln Leu Gln Val Phe Trp Thr Gly Leu Glu Tyr Thr Cys Arg Leu
    1               5                  10                  15

 ctg ggc atc acc act gct gca gcc cca caa atg cct gag acg cta gag       96
 Leu Gly Ile Thr Thr Ala Ala Ala Pro Gln Met Pro Glu Thr Leu Glu
              20                  25                  30

 tgc tgg gct cag tcc tat ttt aca aat gag gaa act gaa gct cag aac      144
 Cys Trp Ala Gln Ser Tyr Phe Thr Asn Glu Glu Thr Glu Ala Gln Asn
          35                  40                  45

 att gag gtg gga att caa aat gag atc tgg gtg gga aca cag cca aac      192
 Ile Glu Val Gly Ile Gln Asn Glu Ile Trp Val Gly Thr Gln Pro Asn
      50                  55                  60

 cat acc agg gta ctt aca agg gag atg cta ttc tac gtg gga gac act      240
 His Thr Arg Val Leu Thr Arg Glu Met Leu Phe Tyr Val Gly Asp Thr
  65                  70                  75                  80

 atc ctc agt agt gcc aat gaa cca tat ggg tct gca gag tcc ttc ctc      288
 Ile Leu Ser Ser Ala Asn Glu Pro Tyr Gly Ser Ala Glu Ser Phe Leu
                  85                  90                  95

 atc acc aaa gag tgg ggt atc agc aca gat ggc ctc aca gtg ttg atc      336
 Ile Thr Lys Glu Trp Gly Ile Ser Thr Asp Gly Leu Thr Val Leu Ile
             100                 105                 110

 ggc gtg ggc act gag acc ttc ctc cag ggc cag ttc aaa agc ctg gct      384
 Gly Val Gly Thr Glu Thr Phe Leu Gln Gly Gln Phe Lys Ser Leu Ala
         115                 120                 125

 ttc tat ctg ctg ttt aca gga gcc gct gtc tcc ata tgt gaa ggg gcc      432
 Phe Tyr Leu Leu Phe Thr Gly Ala Ala Val Ser Ile Cys Glu Gly Ala
     130                 135                 140

 tac ttt gtg gct cag ctg ctg gcc atc tgc ttc cag tgt caa cca ggg      480
 Tyr Phe Val Ala Gln Leu Leu Ala Ile Cys Phe Gln Cys Gln Pro Gly
 145                 150                 155                 160

 tcc ctg gca gac aga gta agg gag aaa gcc cac tgg ctg ggc tgc ttc      528
 Ser Leu Ala Asp Arg Val Arg Glu Lys Ala His Trp Leu Gly Cys Phe
                 165                 170                 175

 cag aag ttc ctg gcc tac ctg ctg ctg tcg gtg gcc tgc ttc ctc cac      576
 Gln Lys Phe Leu Ala Tyr Leu Leu Leu Ser Val Ala Cys Phe Leu His
             180                 185                 190

 ccg gtc ctg gtc tgg cac gtg acc atc cca ggc tcc atg ctc atc atc      624
 Pro Val Leu Val Trp His Val Thr Ile Pro Gly Ser Met Leu Ile Ile
         195                 200                 205

 acc ggc ctg gcc tac ttc ctt ctg agc aag cgg aag aag agg aaa gct      672
 Thr Gly Leu Ala Tyr Phe Leu Leu Ser Lys Arg Lys Lys Arg Lys Ala
     210                 215                 220

 gcc ccc gag gtg ctg gcc tcc cca gag cag tac aca gac ccc tct agc      720
 Ala Pro Glu Val Leu Ala Ser Pro Glu Gln Tyr Thr Asp Pro Ser Ser
 225                 230                 235                 240

 agc gct gtg agc acc acc ggc tct ggg gac aca gag caa acc tac act      768
 Ser Ala Val Ser Thr Thr Gly Ser Gly Asp Thr Glu Gln Thr Tyr Thr
                 245                 250                 255

 ttc cat ggg gcc ctc aag gag ggg ccc agc tcc ctt ttc atc cac atg      816
 Phe His Gly Ala Leu Lys Glu Gly Pro Ser Ser Leu Phe Ile His Met
             260                 265                 270

 aag agt atc ctg aag ggg act aag aag ccc agt gcc ctc cag ccc ccc      864
 Lys Ser Ile Leu Lys Gly Thr Lys Lys Pro Ser Ala Leu Gln Pro Pro
         275                 280                 285

 aac acc ctg atg gag ctg agc ctg gag cca gcc gac tcc ctg gcc aag      912
 Asn Thr Leu Met Glu Leu Ser Leu Glu Pro Ala Asp Ser Leu Ala Lys
     290                 295                 300

 aag aag cag gtg cac ttt gaa gac aac ttg gtc cgc ata gtc ccc tcc      960
 Lys Lys Gln Val His Phe Glu Asp Asn Leu Val Arg Ile Val Pro Ser
 305                 310                 315                 320

 ctc gcc gaa ggt ctg gat gat ggg gac agc ccc act ctt cct gtc atc     1008
 Leu Ala Glu Gly Leu Asp Asp Gly Asp Ser Pro Thr Leu Pro Val Ile
                 325                 330                 335

 tct tac agc cac cgg cct gtt ctg agc gct tgc tcc agc ctg gag gac     1056
 Ser Tyr Ser His Arg Pro Val Leu Ser Ala Cys Ser Ser Leu Glu Asp
             340                 345                 350

 gct cag ata ttt tac aaa ggt atg aaa ata atg gcc aac cag aag cta     1104
 Ala Gln Ile Phe Tyr Lys Gly Met Lys Ile Met Ala Asn Gln Lys Leu
         355                 360                 365

 gta tca gtt tgg ggc cta aat gca gca ggt gtt cct gat aag cag ata     1152
 Val Ser Val Trp Gly Leu Asn Ala Ala Gly Val Pro Asp Lys Gln Ile
     370                 375                 380

 agc aga gct ctt cct gca gta gcc cag gtc tca cca aat gac aaa tgg     1200
 Ser Arg Ala Leu Pro Ala Val Ala Gln Val Ser Pro Asn Asp Lys Trp
 385                 390                 395                 400

 cta atc aag aca ctc ctg caa gcc ctt gat ggt gag agc tgc aga gct     1248
 Leu Ile Lys Thr Leu Leu Gln Ala Leu Asp Gly Glu Ser Cys Arg Ala
                 405                 410                 415

 gtt tct tca gct gcc atc aag gca gga cct cag gac ctg act gtc tac     1296
 Val Ser Ser Ala Ala Ile Lys Ala Gly Pro Gln Asp Leu Thr Val Tyr
             420                 425                 430

 agt cag gga ata gtg aac aat atg gga tat ggg tat aga gta gtt ctg     1344
 Ser Gln Gly Ile Val Asn Asn Met Gly Tyr Gly Tyr Arg Val Val Leu
         435                 440                 445

 tcc tcg aag ccc cag tca gca gag ctg gat gac cag atc gca aga agc     1392
 Ser Ser Lys Pro Gln Ser Ala Glu Leu Asp Asp Gln Ile Ala Arg Ser
     450                 455                 460

 aaa cca gaa agt gtg atg gca gag atg tca gat ccc gtt taa             1434
 Lys Pro Glu Ser Val Met Ala Glu Met Ser Asp Pro Val 
 465                 470                 475





      <210> 838
      <211> 2082
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (1)..(2082)

      <400> 838
  atg atg ctg ctg ttg ctg tgt ctg ggg ttg acc ctc gtc tgt gcc cag      48
  Met Met Leu Leu Leu Leu Cys Leu Gly Leu Thr Leu Val Cys Ala Gln
    1               5                  10                  15

 gag gaa gaa aac aat gat gct gtg aca agc aac ttc gat ctg tca aag       96
 Glu Glu Glu Asn Asn Asp Ala Val Thr Ser Asn Phe Asp Leu Ser Lys
              20                  25                  30

 cac att gct cag gat ata gca tca att cga aca ccg gat gtg agc tca      144
 His Ile Ala Gln Asp Ile Ala Ser Ile Arg Thr Pro Asp Val Ser Ser
          35                  40                  45

 caa ctc aag gag agg ttt gtg aaa tat tgt gaa gaa cat ggg att gat      192
 Gln Leu Lys Glu Arg Phe Val Lys Tyr Cys Glu Glu His Gly Ile Asp
      50                  55                  60

 aag gaa aac ata ttt gac ttg acc aaa gtt gaa ctt aga gat gag gga      240
 Lys Glu Asn Ile Phe Asp Leu Thr Lys Val Glu Leu Arg Asp Glu Gly
  65                  70                  75                  80

 ggt ggc cac tgg gtg cgg gga tcg tgg att ggt ccc ttc aga tcc gcc      288
 Gly Gly His Trp Val Arg Gly Ser Trp Ile Gly Pro Phe Arg Ser Ala
                  85                  90                  95

 ccg gtg tcc aga gga gcc cta gag aat gcc ttg gcc ggc tcg cag ggc      336
 Pro Val Ser Arg Gly Ala Leu Glu Asn Ala Leu Ala Gly Ser Gln Gly
             100                 105                 110

 ctc tcc aac gcc ctg ctc tgg ctc gtc tca cct gca gga gag agg tac      384
 Leu Ser Asn Ala Leu Leu Trp Leu Val Ser Pro Ala Gly Glu Arg Tyr
         115                 120                 125

 cct gcg agt ggg cag ata cct ggc gcc ccc ggt ggc cgt ttg cgc gca      432
 Pro Ala Ser Gly Gln Ile Pro Gly Ala Pro Gly Gly Arg Leu Arg Ala
     130                 135                 140

 tct cag gct ctg cca gcc gct gcc gcc cgg gcg cag ttc aga aag agc      480
 Ser Gln Ala Leu Pro Ala Ala Ala Ala Arg Ala Gln Phe Arg Lys Ser
 145                 150                 155                 160

 cag gtg tcc tcc gga gcc cag gcc gag gcc tct tcc aaa agg atc aag      528
 Gln Val Ser Ser Gly Ala Gln Ala Glu Ala Ser Ser Lys Arg Ile Lys
                 165                 170                 175

 gtg ttt gga ctg ttt gct gta gcc tct gga aaa att aag aat gga gtg      576
 Val Phe Gly Leu Phe Ala Val Ala Ser Gly Lys Ile Lys Asn Gly Val
             180                 185                 190

 gga gag cca ggc ttg ggt tgg gtg aaa cat gta tct ccc aag gtg acc      624
 Gly Glu Pro Gly Leu Gly Trp Val Lys His Val Ser Pro Lys Val Thr
         195                 200                 205

 cta gcc aga aag ccc ttc gat ccc cat cag aga ggt cac atg agc ccc      672
 Leu Ala Arg Lys Pro Phe Asp Pro His Gln Arg Gly His Met Ser Pro
     210                 215                 220

 gag gtc acc tgc ccg cgg agg ggc cac ctg cct cgc ttc cac ccg agg      720
 Glu Val Thr Cys Pro Arg Arg Gly His Leu Pro Arg Phe His Pro Arg
 225                 230                 235                 240

 acc tgg gtt gag ccc gtg gtg gcc tcg tcc cag gtg gct gcc tcc ctc      768
 Thr Trp Val Glu Pro Val Val Ala Ser Ser Gln Val Ala Ala Ser Leu
                 245                 250                 255

 tac gat gcg ggg cta ctc ctc gtg gtg aag gcg tcc tac gga acc gga      816
 Tyr Asp Ala Gly Leu Leu Leu Val Val Lys Ala Ser Tyr Gly Thr Gly
             260                 265                 270

 ggc tcc tcc aac cac agt gcc agc cca tcg ccc cgg ggg gct cta gag      864
 Gly Ser Ser Asn His Ser Ala Ser Pro Ser Pro Arg Gly Ala Leu Glu
         275                 280                 285

 gac caa cag cag aga gcc atc tcc aat ttc tac att atc tac aac ctt      912
 Asp Gln Gln Gln Arg Ala Ile Ser Asn Phe Tyr Ile Ile Tyr Asn Leu
     290                 295                 300

 gtg gtg ggc ctg tcc ccc ctg ctg tcc gcc tac ggg ctg gga tgg ctc      960
 Val Val Gly Leu Ser Pro Leu Leu Ser Ala Tyr Gly Leu Gly Trp Leu
 305                 310                 315                 320

 agc gac cgc tac cac cga aag atc tcc atc tgc atg tcg ctg ctg ggc     1008
 Ser Asp Arg Tyr His Arg Lys Ile Ser Ile Cys Met Ser Leu Leu Gly
                 325                 330                 335

 ttc ctg ctc tcc cgc ctc ggg ctg ctg ctc aag gtg ctg ctg gac tgg     1056
 Phe Leu Leu Ser Arg Leu Gly Leu Leu Leu Lys Val Leu Leu Asp Trp
             340                 345                 350

 cca gtg gag gtg ctg tac ggg gcg gcg gcg ctg aac ggg cta ttc ggc     1104
 Pro Val Glu Val Leu Tyr Gly Ala Ala Ala Leu Asn Gly Leu Phe Gly
         355                 360                 365

 ggc ttc tcc gcc ttc tgg tcc ggg gtc atg gcg ctg gga tcg ctg ggc     1152
 Gly Phe Ser Ala Phe Trp Ser Gly Val Met Ala Leu Gly Ser Leu Gly
     370                 375                 380

 tcc tcc gag ggc cgc cgc tct gtg cgc ctc atc ctc att gac ctg atg     1200
 Ser Ser Glu Gly Arg Arg Ser Val Arg Leu Ile Leu Ile Asp Leu Met
 385                 390                 395                 400

 ctg ggc ttg gcg ggg ttc tgc ggg agc atg gct tcc ggg cat ctc ttc     1248
 Leu Gly Leu Ala Gly Phe Cys Gly Ser Met Ala Ser Gly His Leu Phe
                 405                 410                 415

 aag cag atg gct ggg cac tct ggg cag ggc ctg ata ctg acg gcc tgc     1296
 Lys Gln Met Ala Gly His Ser Gly Gln Gly Leu Ile Leu Thr Ala Cys
             420                 425                 430

 agc gtg agc tgt gcc tcg ttt gcc ctg ctc tac agc ctt ttg gtg cta     1344
 Ser Val Ser Cys Ala Ser Phe Ala Leu Leu Tyr Ser Leu Leu Val Leu
         435                 440                 445

 aag gtc cct gag tcg gtg gcc aaa ccc agc cag gag ctc ccc gcc gtg     1392
 Lys Val Pro Glu Ser Val Ala Lys Pro Ser Gln Glu Leu Pro Ala Val
     450                 455                 460

 gat acc gtg tct ggc acg gtt ggc aca tac cgc act ctg gat cct gat     1440
 Asp Thr Val Ser Gly Thr Val Gly Thr Tyr Arg Thr Leu Asp Pro Asp
 465                 470                 475                 480

 cag ttg gac caa cag tat gca gtg ggg cac cct cca tct cct gga aaa     1488
 Gln Leu Asp Gln Gln Tyr Ala Val Gly His Pro Pro Ser Pro Gly Lys
                 485                 490                 495

 gca aaa ccc cat aaa acc acc att gcc ttg ctc ttt gtg ggt gct atc     1536
 Ala Lys Pro His Lys Thr Thr Ile Ala Leu Leu Phe Val Gly Ala Ile
             500                 505                 510

 ata tat gac ctg gcg gtg gtg ggc aca gtg gac gtg atc cct ctt ttt     1584
 Ile Tyr Asp Leu Ala Val Val Gly Thr Val Asp Val Ile Pro Leu Phe
         515                 520                 525

 gtg ctg agg gag cct ctc ggt tgg aac caa gtg cag gtg ggc tat ggt     1632
 Val Leu Arg Glu Pro Leu Gly Trp Asn Gln Val Gln Val Gly Tyr Gly
     530                 535                 540

 atg gct gca ggg tac acc atc ttc atc acc agc ttc ctg ggt gtc ctg     1680
 Met Ala Ala Gly Tyr Thr Ile Phe Ile Thr Ser Phe Leu Gly Val Leu
 545                 550                 555                 560

 gtc ttc tcc cgc tgc ttt cgg gac acc acc atg atc atg att ggg atg     1728
 Val Phe Ser Arg Cys Phe Arg Asp Thr Thr Met Ile Met Ile Gly Met
                 565                 570                 575

 gtc tcc ttt ggg tca gga gcc ctc ctc ttg gct ttt gtg aaa gag aca     1776
 Val Ser Phe Gly Ser Gly Ala Leu Leu Leu Ala Phe Val Lys Glu Thr
             580                 585                 590

 tac atg ttc tat att gct cga gcc gtc atg ctg ttt gct ctc atc ccc     1824
 Tyr Met Phe Tyr Ile Ala Arg Ala Val Met Leu Phe Ala Leu Ile Pro
         595                 600                 605

 gtc aca acc atc cga tca gct atg tcc aaa ctc ata aag ggc tcc tct     1872
 Val Thr Thr Ile Arg Ser Ala Met Ser Lys Leu Ile Lys Gly Ser Ser
     610                 615                 620

 tat gga aag gtg ttc gtc ata ctg cag ctg tcc ttg gct ctg acc ggc     1920
 Tyr Gly Lys Val Phe Val Ile Leu Gln Leu Ser Leu Ala Leu Thr Gly
 625                 630                 635                 640

 gtg gtg aca tcc acc ttg tac aac aag atc tac cag ctc acc atg gac     1968
 Val Val Thr Ser Thr Leu Tyr Asn Lys Ile Tyr Gln Leu Thr Met Asp
                 645                 650                 655

 atg ttt gtg ggc tcc tgc ttt gct ctc tcc tcc ttt ctc tcc ttc ctg     2016
 Met Phe Val Gly Ser Cys Phe Ala Leu Ser Ser Phe Leu Ser Phe Leu
             660                 665                 670

 gcc atc att cca att agg gct ctg tgc tca gtg cgg ctg aaa tct ccc     2064
 Ala Ile Ile Pro Ile Arg Ala Leu Cys Ser Val Arg Leu Lys Ser Pro
         675                 680                 685

 agc cgc tgg act gtg tga                                             2082
 Ser Arg Trp Thr Val 
     690





      <210> 839
      <211> 5899
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (5)..(5899)

      <400> 839
 cttg atg gtg gcc ggc gtg tac tgc ctc gtg gtg gct gtc atc ttt gct      49
      Met Val Ala Gly Val Tyr Cys Leu Val Val Ala Val Ile Phe Ala
        1               5                  10                  15

 act atc aag act gtc aat tat cgg ctt cat gcc atg ttt gac cag ggc       97
 Thr Ile Lys Thr Val Asn Tyr Arg Leu His Ala Met Phe Asp Gln Gly
                  20                  25                  30

 gag atc gtg gag aag cgc agc tct acc atg ggg gag ctg gag gaa gag      145
 Glu Ile Val Glu Lys Arg Ser Ser Thr Met Gly Glu Leu Glu Glu Glu
              35                  40                  45

 cct gcc cag ggg gac agc aat cca ccc agg gac ccc gga gtg gag atg      193
 Pro Ala Gln Gly Asp Ser Asn Pro Pro Arg Asp Pro Gly Val Glu Met
          50                  55                  60

 aca gtg ttc cgg aaa gtc agt tcc aca ccc ccg gtg cgc tgc agc tcc      241
 Thr Val Phe Arg Lys Val Ser Ser Thr Pro Pro Val Arg Cys Ser Ser
      65                  70                  75

 cag cac tct gtg ttt ggc ttc aac cag gtc tcg gag ctg ctg ccc cga      289
 Gln His Ser Val Phe Gly Phe Asn Gln Val Ser Glu Leu Leu Pro Arg
  80                  85                  90                  95

 atg gag gac tct ggg ccc ctt aga gac atc aag gag ctg gtg cgg gag      337
 Met Glu Asp Ser Gly Pro Leu Arg Asp Ile Lys Glu Leu Val Arg Glu
                 100                 105                 110

 cag ggc agc aac aat gtg atc gtg act tct gcc gac cga gag atg ctg      385
 Gln Gly Ser Asn Asn Val Ile Val Thr Ser Ala Asp Arg Glu Met Leu
             115                 120                 125

 aag ctc agc tcg cag gag aaa ctg att gga gac ctt ccc cag acg cct      433
 Lys Leu Ser Ser Gln Glu Lys Leu Ile Gly Asp Leu Pro Gln Thr Pro
         130                 135                 140

 cca ggg gct gtc cca gac ccc tct ctt gcc agt aca gac tct tca gag      481
 Pro Gly Ala Val Pro Asp Pro Ser Leu Ala Ser Thr Asp Ser Ser Glu
     145                 150                 155

 cct tct ccc ctg gct gga gat gga gcg ccc tgg agt ggg agc agc atg      529
 Pro Ser Pro Leu Ala Gly Asp Gly Ala Pro Trp Ser Gly Ser Ser Met
 160                 165                 170                 175

 gct gac act ccc atg agc ccc ctg ctg aag ggg agc ctc agc cag gag      577
 Ala Asp Thr Pro Met Ser Pro Leu Leu Lys Gly Ser Leu Ser Gln Glu
                 180                 185                 190

 ctg agc aag agc ttc ctg acc ctg acc cag cct gac cgg gcc ctg gtg      625
 Leu Ser Lys Ser Phe Leu Thr Leu Thr Gln Pro Asp Arg Ala Leu Val
             195                 200                 205

 agg acc agc agt cga cgg gaa caa cgc agg ggg gca ggt ggc tat cag      673
 Arg Thr Ser Ser Arg Arg Glu Gln Arg Arg Gly Ala Gly Gly Tyr Gln
         210                 215                 220

 ccc ctt gac cgg cgg ggc tca ggg gag ccc acg ccc cag aaa gcc ggc      721
 Pro Leu Asp Arg Arg Gly Ser Gly Glu Pro Thr Pro Gln Lys Ala Gly
     225                 230                 235

 tcc tca gac tcc tgc ttc agc ggc act gac agg gag aca ttg agc agc      769
 Ser Ser Asp Ser Cys Phe Ser Gly Thr Asp Arg Glu Thr Leu Ser Ser
 240                 245                 250                 255

 ttc aag agt gag aag acc aac tcc acc cat ctg gac agc ccc cca ggg      817
 Phe Lys Ser Glu Lys Thr Asn Ser Thr His Leu Asp Ser Pro Pro Gly
                 260                 265                 270

 ggg cca gcc cct gag ggc agc gac aca gac cca ccc tct gag gct gag      865
 Gly Pro Ala Pro Glu Gly Ser Asp Thr Asp Pro Pro Ser Glu Ala Glu
             275                 280                 285

 ctg cct gcc tca cca gac gcc ggg gtc ccc tca gat gac acg ctg cgt      913
 Leu Pro Ala Ser Pro Asp Ala Gly Val Pro Ser Asp Asp Thr Leu Arg
         290                 295                 300

 tcc ttt gac acg gtc att gga gca ggg acg cca ccg ggc ctg gct gag      961
 Ser Phe Asp Thr Val Ile Gly Ala Gly Thr Pro Pro Gly Leu Ala Glu
     305                 310                 315

 ccg ctc ctg gtc gtg cgg ccc aag gac ttg gcc ctg cta cgg cct agc     1009
 Pro Leu Leu Val Val Arg Pro Lys Asp Leu Ala Leu Leu Arg Pro Ser
 320                 325                 330                 335

 aaa cgg cag cca ccc ctg cga aga cac tct cca cct ggc cgt gcc cct     1057
 Lys Arg Gln Pro Pro Leu Arg Arg His Ser Pro Pro Gly Arg Ala Pro
                 340                 345                 350

 cga cgg ccc ctg ctt gaa ggt ggg ggc ttc ttt gag gat gaa gac act     1105
 Arg Arg Pro Leu Leu Glu Gly Gly Gly Phe Phe Glu Asp Glu Asp Thr
             355                 360                 365

 agt gag ggc agt gaa ctg agc ccg gcc tcc agt ctc cga tcg cag cgc     1153
 Ser Glu Gly Ser Glu Leu Ser Pro Ala Ser Ser Leu Arg Ser Gln Arg
         370                 375                 380

 cgc tac agt act gac agc tcc tct tct act tcc tgc tac tcc cct gag     1201
 Arg Tyr Ser Thr Asp Ser Ser Ser Ser Thr Ser Cys Tyr Ser Pro Glu
     385                 390                 395

 agc tcc cgg ggt gca gca ggg gga ccc cgg aag cgg agg gcc ccc cat     1249
 Ser Ser Arg Gly Ala Ala Gly Gly Pro Arg Lys Arg Arg Ala Pro His
 400                 405                 410                 415

 ggg gct gag gag gga act gct gtg ccc ccc aag cgg cca tat ggg acc     1297
 Gly Ala Glu Glu Gly Thr Ala Val Pro Pro Lys Arg Pro Tyr Gly Thr
                 420                 425                 430

 cag cgg acg cct agt acc gcc agc gct aaa aca cat gcc cgt gtg ctg     1345
 Gln Arg Thr Pro Ser Thr Ala Ser Ala Lys Thr His Ala Arg Val Leu
             435                 440                 445

 agc atg gat ggg gct ggg ggt gat gtt ctg agg ccc cca ctg gct ggc     1393
 Ser Met Asp Gly Ala Gly Gly Asp Val Leu Arg Pro Pro Leu Ala Gly
         450                 455                 460

 tgc aag gca gag ctg gag gcc cag gtt ggg gtg gag cag gct gct agt     1441
 Cys Lys Ala Glu Leu Glu Ala Gln Val Gly Val Glu Gln Ala Ala Ser
     465                 470                 475

 gag cct gtt gtg ctg cct gct gag gcg cga agg gga ccc gct gcc aac     1489
 Glu Pro Val Val Leu Pro Ala Glu Ala Arg Arg Gly Pro Ala Ala Asn
 480                 485                 490                 495

 cag ccc ggc tgg cgg ggg gag ctg cag gag gaa ggt gct gtg ggg gga     1537
 Gln Pro Gly Trp Arg Gly Glu Leu Gln Glu Glu Gly Ala Val Gly Gly
                 500                 505                 510

 gcg gcc gag gag act ggc agg cgg gac cgc tca agc agt gtg agg cgg     1585
 Ala Ala Glu Glu Thr Gly Arg Arg Asp Arg Ser Ser Ser Val Arg Arg
             515                 520                 525

 acc cag gcc att cgg aga cgc cac aat gca ggc agc aac ccc acc cct     1633
 Thr Gln Ala Ile Arg Arg Arg His Asn Ala Gly Ser Asn Pro Thr Pro
         530                 535                 540

 cca gcc tct gtc atg ggc tcg ccg ccc agc agc ctg cag gaa gct cag     1681
 Pro Ala Ser Val Met Gly Ser Pro Pro Ser Ser Leu Gln Glu Ala Gln
     545                 550                 555

 cgg ggc cgg gct gcc tcc cac tcc cgg gcg ctg acg ctg ccc tct gcg     1729
 Arg Gly Arg Ala Ala Ser His Ser Arg Ala Leu Thr Leu Pro Ser Ala
 560                 565                 570                 575

 ctg cat ttc gcc tct tca ctg ttg ctc acc cgg gcc ggt gcc aat gtg     1777
 Leu His Phe Ala Ser Ser Leu Leu Leu Thr Arg Ala Gly Ala Asn Val
                 580                 585                 590

 cat gag gcc tgc acc ttt gat gac act tct gag ggt gct gtg cac tat     1825
 His Glu Ala Cys Thr Phe Asp Asp Thr Ser Glu Gly Ala Val His Tyr
             595                 600                 605

 ttc tac gat gag agc ggt gtg cgg cgt tcc tac acc ttt ggc ctg gct     1873
 Phe Tyr Asp Glu Ser Gly Val Arg Arg Ser Tyr Thr Phe Gly Leu Ala
         610                 615                 620

 gga ggc ggc tac gag aac cct gta ggg cag caa ggg gag cag aca gct     1921
 Gly Gly Gly Tyr Glu Asn Pro Val Gly Gln Gln Gly Glu Gln Thr Ala
     625                 630                 635

 aat gga gcc tgg gac cga cac tcg cat tcc tcc agc ttc cac tcg gct     1969
 Asn Gly Ala Trp Asp Arg His Ser His Ser Ser Ser Phe His Ser Ala
 640                 645                 650                 655

 gat gtc cct gag gct aca ggc ggc ctg aac ctg ctg cag ccg agg cct     2017
 Asp Val Pro Glu Ala Thr Gly Gly Leu Asn Leu Leu Gln Pro Arg Pro
                 660                 665                 670

 gtg gtt ctg cag ggc atg cag gtg cgc cgg gtg ccc ctg gag atc ccg     2065
 Val Val Leu Gln Gly Met Gln Val Arg Arg Val Pro Leu Glu Ile Pro
             675                 680                 685

 gag ttt gac ctg ctg gac cag gac tcc ctg cac gaa tcc cag gag cag     2113
 Glu Phe Asp Leu Leu Asp Gln Asp Ser Leu His Glu Ser Gln Glu Gln
         690                 695                 700

 aca ctg atg gaa gaa gcg cca ccc cgg gcc cag cat agt tac aag tac     2161
 Thr Leu Met Glu Glu Ala Pro Pro Arg Ala Gln His Ser Tyr Lys Tyr
     705                 710                 715

 tgg ctt ctc cct ggc cgc tgg acc tct gtg cgc tat gag cgg ctt gcc     2209
 Trp Leu Leu Pro Gly Arg Trp Thr Ser Val Arg Tyr Glu Arg Leu Ala
 720                 725                 730                 735

 ctg ctg gct ctg ctg gac cgg acg cgg gga gtg ctg gag aac atc ttc     2257
 Leu Leu Ala Leu Leu Asp Arg Thr Arg Gly Val Leu Glu Asn Ile Phe
                 740                 745                 750

 ggc gtg ggc ctg agc agc ctt gtg gcc ttc ctg ggc tac ctg ctg ctg     2305
 Gly Val Gly Leu Ser Ser Leu Val Ala Phe Leu Gly Tyr Leu Leu Leu
             755                 760                 765

 ctc aag ggc ttc ttc act gac atc tgg gtc ttc cag ttc tgc ctg gtc     2353
 Leu Lys Gly Phe Phe Thr Asp Ile Trp Val Phe Gln Phe Cys Leu Val
         770                 775                 780

 atc gcc tcc tgc cag tac tcc ttg ctg aag agc gtg cag cct gat gcg     2401
 Ile Ala Ser Cys Gln Tyr Ser Leu Leu Lys Ser Val Gln Pro Asp Ala
     785                 790                 795

 gcg tcc ccc atg cac ggc cac aac tgg gtg atc gcg tac agc cgt cct     2449
 Ala Ser Pro Met His Gly His Asn Trp Val Ile Ala Tyr Ser Arg Pro
 800                 805                 810                 815

 gtc tac ttc tgc atc tgc tgt ctg ctc atc tgg ctg ctg gac gcc ctg     2497
 Val Tyr Phe Cys Ile Cys Cys Leu Leu Ile Trp Leu Leu Asp Ala Leu
                 820                 825                 830

 ggc tca gct cag ccc ttc cca cct gtc tcc ctc tac ggc ctc acg ctc     2545
 Gly Ser Ala Gln Pro Phe Pro Pro Val Ser Leu Tyr Gly Leu Thr Leu
             835                 840                 845

 ttc tct gcc tcc ttc ttc ttc tgt gcc cga gac gtg gcc act gtg ttc     2593
 Phe Ser Ala Ser Phe Phe Phe Cys Ala Arg Asp Val Ala Thr Val Phe
         850                 855                 860

 acc ctg tgc ttc ccc ttc gtc ttc ctc ctg ggc ctc ctg ccc cag gtc     2641
 Thr Leu Cys Phe Pro Phe Val Phe Leu Leu Gly Leu Leu Pro Gln Val
     865                 870                 875

 aac acc tgc ctc atg tac ctg ctg gag caa ata gat atg cac ggc ttc     2689
 Asn Thr Cys Leu Met Tyr Leu Leu Glu Gln Ile Asp Met His Gly Phe
 880                 885                 890                 895

 ggg ggc aca gct gcc acc agc ccg ctc acg gca gtc ttc agc ctc tcc     2737
 Gly Gly Thr Ala Ala Thr Ser Pro Leu Thr Ala Val Phe Ser Leu Ser
                 900                 905                 910

 cgc agc ctg ctg gct gct gcc ctg ctc tac ggt ttc tgc ctt ggg gcc     2785
 Arg Ser Leu Leu Ala Ala Ala Leu Leu Tyr Gly Phe Cys Leu Gly Ala
             915                 920                 925

 atc aag act ccg tgg cca gag cag cac gtc cct gtc ctc ttc tca gtc     2833
 Ile Lys Thr Pro Trp Pro Glu Gln His Val Pro Val Leu Phe Ser Val
         930                 935                 940

 ttc tgt ggc ctc ctg gtg gca ctg tcc tac cac ctg agc cgg cag agc     2881
 Phe Cys Gly Leu Leu Val Ala Leu Ser Tyr His Leu Ser Arg Gln Ser
     945                 950                 955

 agc gac ccc acc gtg ctc tgg tct ctg atc cgg agc aag ctg ttc cct     2929
 Ser Asp Pro Thr Val Leu Trp Ser Leu Ile Arg Ser Lys Leu Phe Pro
 960                 965                 970                 975

 gag ctg gag gag cgc agc ttg gag aca gcc cgg gcc gag ccc ccg gac     2977
 Glu Leu Glu Glu Arg Ser Leu Glu Thr Ala Arg Ala Glu Pro Pro Asp
                 980                 985                 990

 ccc ttg ccg gac aag atg cgc cag tcg gtg cgt gag gtc ttg cac tcc     3025
 Pro Leu Pro Asp Lys Met Arg Gln Ser Val Arg Glu Val Leu His Ser
             995                1000                1005

 gac ctg gtg atg tgt gtg gtg atc gcc gtg ctc acc ttc gcc atc agc     3073
 Asp Leu Val Met Cys Val Val Ile Ala Val Leu Thr Phe Ala Ile Ser
        1010                1015                1020

 gcc agc acc gtc ttt att gcc ctg aag tcg gtg ctg ggt ttc gtg ttg     3121
 Ala Ser Thr Val Phe Ile Ala Leu Lys Ser Val Leu Gly Phe Val Leu
    1025                1030                1035

 tac gca ctg gct ggg gcc gtg ggc ttc ttc aca cat tac ctg ctg cca     3169
 Tyr Ala Leu Ala Gly Ala Val Gly Phe Phe Thr His Tyr Leu Leu Pro
1040                1045                1050                1055

 caa ctc cgc aaa cag ctg ccc tgg ttc tgc ctg tca cag ccc gtg ctg     3217
 Gln Leu Arg Lys Gln Leu Pro Trp Phe Cys Leu Ser Gln Pro Val Leu
                1060                1065                1070

 aag ccg ctg gag tac agc cag tat gaa gtg cgc ggt gcc gcc cag gtg     3265
 Lys Pro Leu Glu Tyr Ser Gln Tyr Glu Val Arg Gly Ala Ala Gln Val
            1075                1080                1085

 atg tgg ttt gag aag ctg tat gct ggc ctg cag tgc gta gag aag tac     3313
 Met Trp Phe Glu Lys Leu Tyr Ala Gly Leu Gln Cys Val Glu Lys Tyr
        1090                1095                1100

 ctc atc tac ccc gcc gtg gtg ctc aac gcc ctc acg gtg gac gcc cac     3361
 Leu Ile Tyr Pro Ala Val Val Leu Asn Ala Leu Thr Val Asp Ala His
    1105                1110                1115

 aca gtc gtc agc cac ccg gac aag tac tgc ttc tac tgc cgg gcg ctg     3409
 Thr Val Val Ser His Pro Asp Lys Tyr Cys Phe Tyr Cys Arg Ala Leu
1120                1125                1130                1135

 ctg atg acc gtg gct ggg ctg aag ctg ctg cgc tca gcc ttc tgc tgc     3457
 Leu Met Thr Val Ala Gly Leu Lys Leu Leu Arg Ser Ala Phe Cys Cys
                1140                1145                1150

 ccc cca cag cag tac ctg acg ttg gcc ttc acc gtc ctg ctc ttc cac     3505
 Pro Pro Gln Gln Tyr Leu Thr Leu Ala Phe Thr Val Leu Leu Phe His
            1155                1160                1165

 ttt gac tac ccg cgc ctc tcc cag ggc ttt ctg ctt gac tac ttc ctc     3553
 Phe Asp Tyr Pro Arg Leu Ser Gln Gly Phe Leu Leu Asp Tyr Phe Leu
        1170                1175                1180

 atg tcc ctg ctt tgc agc aag ctg tgg gac ttg ctg tac aag ctg cgt     3601
 Met Ser Leu Leu Cys Ser Lys Leu Trp Asp Leu Leu Tyr Lys Leu Arg
    1185                1190                1195

 ttc gtg ctg acc tac atc gcg ccc tgg cag atc acc tgg ggc tcg gct     3649
 Phe Val Leu Thr Tyr Ile Ala Pro Trp Gln Ile Thr Trp Gly Ser Ala
1200                1205                1210                1215

 ttc cac gct ttt gcc cag ccg ttt gcc tgt gcc acg tat cca gcc tgt     3697
 Phe His Ala Phe Ala Gln Pro Phe Ala Cys Ala Thr Tyr Pro Ala Cys
                1220                1225                1230

 gtt tgg gcc ctg ctc tcg ggg ctc ttc tcc acg cct ctc aac cca ctg     3745
 Val Trp Ala Leu Leu Ser Gly Leu Phe Ser Thr Pro Leu Asn Pro Leu
            1235                1240                1245

 cta ggc agt gcc gtc ttc atc atg tcc tac gct cgg ccc ctc aag ttc     3793
 Leu Gly Ser Ala Val Phe Ile Met Ser Tyr Ala Arg Pro Leu Lys Phe
        1250                1255                1260

 tgg gag cgc gac tac aag gag agc atg agc agg gtg cac cct ctc ttc     3841
 Trp Glu Arg Asp Tyr Lys Glu Ser Met Ser Arg Val His Pro Leu Phe
    1265                1270                1275

 acc ttc ttg gcc aac cgc ctt gtt gca ctc tct ctg aac agc act aaa     3889
 Thr Phe Leu Ala Asn Arg Leu Val Ala Leu Ser Leu Asn Ser Thr Lys
1280                1285                1290                1295

 cgt gtg gat cat tcc aac acc cgc ctg gtc aca cag ctg gac agg aac     3937
 Arg Val Asp His Ser Asn Thr Arg Leu Val Thr Gln Leu Asp Arg Asn
                1300                1305                1310

 cct ggc gct gat gac aac aac ctc aac tcc atc ttc tat gag cac ttg     3985
 Pro Gly Ala Asp Asp Asn Asn Leu Asn Ser Ile Phe Tyr Glu His Leu
            1315                1320                1325

 aca cgt tcg ctg cag cac aca ctg tgt ggg gac ctg gtg ctg ggc cgc     4033
 Thr Arg Ser Leu Gln His Thr Leu Cys Gly Asp Leu Val Leu Gly Arg
        1330                1335                1340

 tgg ggc aac tat ggc cct ggt gac tgc ttc gtc ctg gcc tct gac tac     4081
 Trp Gly Asn Tyr Gly Pro Gly Asp Cys Phe Val Leu Ala Ser Asp Tyr
    1345                1350                1355

 ctc aac gcc ctg gtg cac ctc atc gag gtt ggc aat ggc ctc gtc acc     4129
 Leu Asn Ala Leu Val His Leu Ile Glu Val Gly Asn Gly Leu Val Thr
1360                1365                1370                1375

 ttc cag ctg cgt ggc ctt gag ttc cgg ggc act tac tgc cag cag cgc     4177
 Phe Gln Leu Arg Gly Leu Glu Phe Arg Gly Thr Tyr Cys Gln Gln Arg
                1380                1385                1390

 gag gtg gag gct atc acc gag ggt gtg gag gag gac gag ggc tgt tgc     4225
 Glu Val Glu Ala Ile Thr Glu Gly Val Glu Glu Asp Glu Gly Cys Cys
            1395                1400                1405

 tgc tgt gaa cct ggc cac ctg cca cgg gtc ctg tcc ttc aat gct gcc     4273
 Cys Cys Glu Pro Gly His Leu Pro Arg Val Leu Ser Phe Asn Ala Ala
        1410                1415                1420

 ttt ggg cag cgc tgg ctg gct tgg gag gta aca gcc agc aag tac gtg     4321
 Phe Gly Gln Arg Trp Leu Ala Trp Glu Val Thr Ala Ser Lys Tyr Val
    1425                1430                1435

 ctg gag ggc tat agc att agt gac aat aat gct gcc tcc atg ctg cag     4369
 Leu Glu Gly Tyr Ser Ile Ser Asp Asn Asn Ala Ala Ser Met Leu Gln
1440                1445                1450                1455

 gtt ttc gac ctc cgc aag atc ctc atc acc tac tat gtc aag agc atc     4417
 Val Phe Asp Leu Arg Lys Ile Leu Ile Thr Tyr Tyr Val Lys Ser Ile
                1460                1465                1470

 atc tac tac gtg agc cgc tca cca aag ctg gag gtg tgg ctc agc cat     4465
 Ile Tyr Tyr Val Ser Arg Ser Pro Lys Leu Glu Val Trp Leu Ser His
            1475                1480                1485

 gag ggc atc acg gca gcc ctg agg cct gtg cgg gtg ccc ggc tat gcc     4513
 Glu Gly Ile Thr Ala Ala Leu Arg Pro Val Arg Val Pro Gly Tyr Ala
        1490                1495                1500

 gac tcg gat ccc acc ttc tcg ctg agt gtg gat gag gac tat gac ctc     4561
 Asp Ser Asp Pro Thr Phe Ser Leu Ser Val Asp Glu Asp Tyr Asp Leu
    1505                1510                1515

 cgc ctg tct ggc ctc tcg ctg ccc tcc ttt tgt gct gtg cac ctc gag     4609
 Arg Leu Ser Gly Leu Ser Leu Pro Ser Phe Cys Ala Val His Leu Glu
1520                1525                1530                1535

 tgg atc cag tac tgc gcc tcc cgg cgc agc cag ccc gtg gac cag gat     4657
 Trp Ile Gln Tyr Cys Ala Ser Arg Arg Ser Gln Pro Val Asp Gln Asp
                1540                1545                1550

 tgg aac tcc ccg ctg gtc acg ctg tgt ttt ggc ctg tgt gtg ctg ggc     4705
 Trp Asn Ser Pro Leu Val Thr Leu Cys Phe Gly Leu Cys Val Leu Gly
            1555                1560                1565

 cgc cgg gcc ctg ggg aca gcc tct cac agc atg tct gca agc ctg gag     4753
 Arg Arg Ala Leu Gly Thr Ala Ser His Ser Met Ser Ala Ser Leu Glu
        1570                1575                1580

 ccc ttc ctc tac ggc ctg cac gcc ctg ttc aag ggg gat ttt cgc atc     4801
 Pro Phe Leu Tyr Gly Leu His Ala Leu Phe Lys Gly Asp Phe Arg Ile
    1585                1590                1595

 acc tcc cca cgt gac gag tgg gtc ttt gcc gac atg gac ctg ctt cac     4849
 Thr Ser Pro Arg Asp Glu Trp Val Phe Ala Asp Met Asp Leu Leu His
1600                1605                1610                1615

 cgc gtt gtg gcg cct ggg gtt cgc atg gcc ctc aag ctt cac cag gac     4897
 Arg Val Val Ala Pro Gly Val Arg Met Ala Leu Lys Leu His Gln Asp
                1620                1625                1630

 cac ttc acg tcc cca gat gaa tat gag gag cca gca gcc cta tac gat     4945
 His Phe Thr Ser Pro Asp Glu Tyr Glu Glu Pro Ala Ala Leu Tyr Asp
            1635                1640                1645

 gcc att gcg gcc aac gag gag cgg ctg gtc atc tca cat gag ggt gac     4993
 Ala Ile Ala Ala Asn Glu Glu Arg Leu Val Ile Ser His Glu Gly Asp
        1650                1655                1660

 cca gca tgg cgc agc gcc atc ctc agc aac acg ccc tcc ctg ctg gcg     5041
 Pro Ala Trp Arg Ser Ala Ile Leu Ser Asn Thr Pro Ser Leu Leu Ala
    1665                1670                1675

 ctg cgc cat gtc ctg gat gat gcc tcc gac gag tac aag atc atc atg     5089
 Leu Arg His Val Leu Asp Asp Ala Ser Asp Glu Tyr Lys Ile Ile Met
1680                1685                1690                1695

 ctc aac cgg cgc cac ctc agc ttc cga gtc atc aag gtg aac cgg gag     5137
 Leu Asn Arg Arg His Leu Ser Phe Arg Val Ile Lys Val Asn Arg Glu
                1700                1705                1710

 tgc gtg cgc ggc ctg tgg gcc ggg cag cag cag gag ctg gtg ttc ctg     5185
 Cys Val Arg Gly Leu Trp Ala Gly Gln Gln Gln Glu Leu Val Phe Leu
            1715                1720                1725

 cgc aac cgc aac ccc gag cgt ggc agc atc cag aac gcc aag cag gcg     5233
 Arg Asn Arg Asn Pro Glu Arg Gly Ser Ile Gln Asn Ala Lys Gln Ala
        1730                1735                1740

 ctt cgc aac atg atc aac tcc tcc tgt gac cag ccg ctg ggc tac ccc     5281
 Leu Arg Asn Met Ile Asn Ser Ser Cys Asp Gln Pro Leu Gly Tyr Pro
    1745                1750                1755

 atc tac gtg tcg cct ctc acc acc tcg ctg gct ggc agc cac ccc cag     5329
 Ile Tyr Val Ser Pro Leu Thr Thr Ser Leu Ala Gly Ser His Pro Gln
1760                1765                1770                1775

 cta cgg gca ctg tgg ggt ggc ccc atc agc ctg ggt gcc att gcc cac     5377
 Leu Arg Ala Leu Trp Gly Gly Pro Ile Ser Leu Gly Ala Ile Ala His
                1780                1785                1790

 tgg ctc ctg cgc acc tgg gag agg ctt cac aag ggc tgt ggc gcc ggc     5425
 Trp Leu Leu Arg Thr Trp Glu Arg Leu His Lys Gly Cys Gly Ala Gly
            1795                1800                1805

 tgc aat agt ggc ggg aac gtg gat gat tca gac tgt agt ggg ggc ggt     5473
 Cys Asn Ser Gly Gly Asn Val Asp Asp Ser Asp Cys Ser Gly Gly Gly
        1810                1815                1820

 ggc ctg acc tcc ctc agc aat aac ccc ccc gtg gca cac ccc aca cct     5521
 Gly Leu Thr Ser Leu Ser Asn Asn Pro Pro Val Ala His Pro Thr Pro
    1825                1830                1835

 gag aac acg gca gag ggt ccc cgg acc tca cgg ccc cct ggc ccg ggt     5569
 Glu Asn Thr Ala Glu Gly Pro Arg Thr Ser Arg Pro Pro Gly Pro Gly
1840                1845                1850                1855

 ctc ctc agt tct gag ggc ccc agt gga aag tgg agc ctg ggg ggc cgg     5617
 Leu Leu Ser Ser Glu Gly Pro Ser Gly Lys Trp Ser Leu Gly Gly Arg
                1860                1865                1870

 aag ggg ctg gga gga tct gac ggg gag cca gcc tca ggg agc ccc aaa     5665
 Lys Gly Leu Gly Gly Ser Asp Gly Glu Pro Ala Ser Gly Ser Pro Lys
            1875                1880                1885

 gga ggt acc ccc aaa tct cag gcg cct cta gac ctc agc ctc agc ctc     5713
 Gly Gly Thr Pro Lys Ser Gln Ala Pro Leu Asp Leu Ser Leu Ser Leu
        1890                1895                1900

 agc ctc agc ctc agc ccc gat gtc agc act gag gcc tca ccc ccc aga     5761
 Ser Leu Ser Leu Ser Pro Asp Val Ser Thr Glu Ala Ser Pro Pro Arg
    1905                1910                1915

 gct tcc cag gac att cct tgc ttg gac agc agt gcc cct gag agt ggc     5809
 Ala Ser Gln Asp Ile Pro Cys Leu Asp Ser Ser Ala Pro Glu Ser Gly
1920                1925                1930                1935

 aca cct atg ggt gcc ctg ggc gac tgg cct gcc cct att gag gag cgt     5857
 Thr Pro Met Gly Ala Leu Gly Asp Trp Pro Ala Pro Ile Glu Glu Arg
                1940                1945                1950

 gag agc ccg gca gcc cag ccc ctg ctg gaa cac cag tac tga             5899
 Glu Ser Pro Ala Ala Gln Pro Leu Leu Glu His Gln Tyr 
            1955                1960





      <210> 840
      <211> 1316
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (36)..(1316)

      <400> 840
 gtacaatcct tggatttacc ctccgaccat acaga   atg agc tac cgg gaa gtc      53
                                          Met Ser Tyr Arg Glu Val
                                            1               5

 aag tac ttc tcc ttt cct ggg gaa ctt ctg atg agg atg tta cag atg      101
 Lys Tyr Phe Ser Phe Pro Gly Glu Leu Leu Met Arg Met Leu Gln Met
              10                  15                  20

 ctg gtc tta cca ctt atc atc tcc agt ctt gtc aca gtg tgc att ccc      149
 Leu Val Leu Pro Leu Ile Ile Ser Ser Leu Val Thr Val Cys Ile Pro
          25                  30                  35

 cct caa tca ctt acc tca gaa gaa atc ttt ggt gtc acc cca gtt ttc      197
 Pro Gln Ser Leu Thr Ser Glu Glu Ile Phe Gly Val Thr Pro Val Phe
      40                  45                  50

 tgg aag tgg gga gca caa ctt ttg aca tgc aat ctc tgt ggt gtt ggg      245
 Trp Lys Trp Gly Ala Gln Leu Leu Thr Cys Asn Leu Cys Gly Val Gly
  55                  60                  65                  70

 cat gat gta agt aaa aga gca gct tca agt gag cca gag att ttg atc      293
 His Asp Val Ser Lys Arg Ala Ala Ser Ser Glu Pro Glu Ile Leu Ile
                  75                  80                  85

 agt tct cgt ttg gaa gaa att ttt gaa aaa ttt aaa gaa aag aat gct      341
 Ser Ser Arg Leu Glu Glu Ile Phe Glu Lys Phe Lys Glu Lys Asn Ala
              90                  95                 100

 gtg gaa ctg cag gtt tct tct gct gat atc atg gtt tcc aag aga gtg      389
 Val Glu Leu Gln Val Ser Ser Ala Asp Ile Met Val Ser Lys Arg Val
         105                 110                 115

 agt tac ctg gtt aat tct gac ttg gag atg agt aat aca gat act caa      437
 Ser Tyr Leu Val Asn Ser Asp Leu Glu Met Ser Asn Thr Asp Thr Gln
     120                 125                 130

 gtt aac cag gat gtt agt ctg tgg gtc agt gat cag gta tct cca agt      485
 Val Asn Gln Asp Val Ser Leu Trp Val Ser Asp Gln Val Ser Pro Ser
 135                 140                 145                 150

 caa gac att cct cag ccg ccc ctg tgg ttg tcc tgt gag gtg gtt ggt      533
 Gln Asp Ile Pro Gln Pro Pro Leu Trp Leu Ser Cys Glu Val Val Gly
                 155                 160                 165

 ggc aaa gag agc ttt gcc atg ctt ttc ctg gaa aga ttc act gat tca      581
 Gly Lys Glu Ser Phe Ala Met Leu Phe Leu Glu Arg Phe Thr Asp Ser
             170                 175                 180

 atc ctt cag cta ata ttt ggt gga atg cct act aaa gcc atg gca tgc      629
 Ile Leu Gln Leu Ile Phe Gly Gly Met Pro Thr Lys Ala Met Ala Cys
         185                 190                 195

 aat tct gcc gta gga cat gaa gtc att caa aag gca att gcg caa tta      677
 Asn Ser Ala Val Gly His Glu Val Ile Gln Lys Ala Ile Ala Gln Leu
     200                 205                 210

 cag gat ggg gaa caa ctg agc ttg gca gca gtt cat gat aag ggc caa      725
 Gln Asp Gly Glu Gln Leu Ser Leu Ala Ala Val His Asp Lys Gly Gln
 215                 220                 225                 230

 tat gca gag gtc gag aat agt ggg cag gag cat cag aga aga gtt ggc      773
 Tyr Ala Glu Val Glu Asn Ser Gly Gln Glu His Gln Arg Arg Val Gly
                 235                 240                 245

 gtg aga acg gaa cag cac cac aaa ata gaa ggc gag agg gaa aaa agc      821
 Val Arg Thr Glu Gln His His Lys Ile Glu Gly Glu Arg Glu Lys Ser
             250                 255                 260

 atc tcg gag gaa gaa aat act gcc gcc tgg tac tcc ctg gta ccc aga      869
 Ile Ser Glu Glu Glu Asn Thr Ala Ala Trp Tyr Ser Leu Val Pro Arg
         265                 270                 275

 gat atc cgg cgt att gtg ctt aca cta ctc gcc ggt tcc aca ggg aga      917
 Asp Ile Arg Arg Ile Val Leu Thr Leu Leu Ala Gly Ser Thr Gly Arg
     280                 285                 290

 gag ccg gaa gaa ttg cag gct ttg gtg gtg aca agt tca ggc act cat      965
 Glu Pro Glu Glu Leu Gln Ala Leu Val Val Thr Ser Ser Gly Thr His
 295                 300                 305                 310

 ggg aaa gag aga atg gcg gcg cta gat agt aag gca tca ggg aag atg     1013
 Gly Lys Glu Arg Met Ala Ala Leu Asp Ser Lys Ala Ser Gly Lys Met
                 315                 320                 325

 gga atg cga gct gta gtc tat tat atg act acc acc atc att gct gtg     1061
 Gly Met Arg Ala Val Val Tyr Tyr Met Thr Thr Thr Ile Ile Ala Val
             330                 335                 340

 gtg att ggc ata atc att gtc atc atc atc cat cct ggg aag ggc aca     1109
 Val Ile Gly Ile Ile Ile Val Ile Ile Ile His Pro Gly Lys Gly Thr
         345                 350                 355

 aag gaa aac atg cac aga gaa ggc aaa att gta cga gtg aca gct gca     1157
 Lys Glu Asn Met His Arg Glu Gly Lys Ile Val Arg Val Thr Ala Ala
     360                 365                 370

 gat gcc ttc ctg gac ttg atc agg aac atg ttc cct cca aat ctg gta     1205
 Asp Ala Phe Leu Asp Leu Ile Arg Asn Met Phe Pro Pro Asn Leu Val
 375                 380                 385                 390

 gaa gcc tgc ttt aaa cag tct acc aag cac cta atg gac tct aaa gga     1253
 Glu Ala Cys Phe Lys Gln Ser Thr Lys His Leu Met Asp Ser Lys Gly
                 395                 400                 405

 gag cca aag cag aaa gga atg gca tca tca ttc atg gaa atc ctg cta     1301
 Glu Pro Lys Gln Lys Gly Met Ala Ser Ser Phe Met Glu Ile Leu Leu
             410                 415                 420

 tat gcc aag cac taa                                                 1316
 Tyr Ala Lys His 
         425





      <210> 841
      <211> 518
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (48)..(518)

      <400> 841
 gcagtaacag ccctcatggg agccccacct ctcctctgga cagtaat  atg ctg ctg      56
                                                      Met Leu Leu
                                                        1

 gtc ata att gtt tct gtt ggc gtc atc acc atc gtg gtg gtt gtg att      104
 Val Ile Ile Val Ser Val Gly Val Ile Thr Ile Val Val Val Val Ile
       5                  10                  15

 atc gct gtc ttt tgt acc cgt cgt acc acc tct cac cag aaa aag aaa      152
 Ile Ala Val Phe Cys Thr Arg Arg Thr Thr Ser His Gln Lys Lys Lys
  20                  25                  30                  35

 cga gct gcc tgc aaa tca gtg aat ggc tct cat aag tac aaa ggg aat      200
 Arg Ala Ala Cys Lys Ser Val Asn Gly Ser His Lys Tyr Lys Gly Asn
                  40                  45                  50

 tcc aaa gat gtg aaa cct cca gat ctc tgg atc cat cat gag aga ctg      248
 Ser Lys Asp Val Lys Pro Pro Asp Leu Trp Ile His His Glu Arg Leu
              55                  60                  65

 gag ctg aaa ccc att gat aag tct cca gac cca aac ccc atc atg act      296
 Glu Leu Lys Pro Ile Asp Lys Ser Pro Asp Pro Asn Pro Ile Met Thr
          70                  75                  80

 gat act cca att cct cgc aac tct caa gat atc aca cca gtt gac aac      344
 Asp Thr Pro Ile Pro Arg Asn Ser Gln Asp Ile Thr Pro Val Asp Asn
      85                  90                  95

 tcc atg gac agc aat atc cat caa agg cga aat tca tac aga gct ggc      392
 Ser Met Asp Ser Asn Ile His Gln Arg Arg Asn Ser Tyr Arg Ala Gly
 100                 105                 110                 115

 ttc cag ctt gca ttg tgg tat tca gaa cat tct tgg tct gga ggc tct      440
 Phe Gln Leu Ala Leu Trp Tyr Ser Glu His Ser Trp Ser Gly Gly Ser
                 120                 125                 130

 tat aga cac cct gtg aag tat ggt ggg cag cat tgt gac atc cac att      488
 Tyr Arg His Pro Val Lys Tyr Gly Gly Gln His Cys Asp Ile His Ile
             135                 140                 145

 gat tca gca gga act ctt gta atg ctc taa                              518
 Asp Ser Ala Gly Thr Leu Val Met Leu 
         150                 155





      <210> 842
      <211> 2094
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (1)..(2094)

      <400> 842
  atg gtg ggt cag agg gcc cag cac agc cca gtc agc ctc ctg ctg ctg      48
  Met Val Gly Gln Arg Ala Gln His Ser Pro Val Ser Leu Leu Leu Leu
    1               5                  10                  15

 ata cac ctc tgc ctt ctg cac ctg agg gcc tca ggc cag ccc cac ccg       96
 Ile His Leu Cys Leu Leu His Leu Arg Ala Ser Gly Gln Pro His Pro
              20                  25                  30

 acc ccc gag gcc cct gta gag gag gtg gtg tct gtc cag gga gtg cga      144
 Thr Pro Glu Ala Pro Val Glu Glu Val Val Ser Val Gln Gly Val Arg
          35                  40                  45

 ggt ggc tcc gtg gag ctg gcc tgt ggc tca ggg cct gcc ccg ctg ctg      192
 Gly Gly Ser Val Glu Leu Ala Cys Gly Ser Gly Pro Ala Pro Leu Leu
      50                  55                  60

 gtc ctc tgg agc ttc acc ccc ctg ggc tcc ctg gtt ccc cgg cct gtg      240
 Val Leu Trp Ser Phe Thr Pro Leu Gly Ser Leu Val Pro Arg Pro Val
  65                  70                  75                  80

 gcc gtc acc gat gga gcc atg tcc aag gtg gag gcc atc gcc tcg gct      288
 Ala Val Thr Asp Gly Ala Met Ser Lys Val Glu Ala Ile Ala Ser Ala
                  85                  90                  95

 ctg gga gtc gtg agt ctg agg aac agc agc ctg gtg ctg ggg gag ctt      336
 Leu Gly Val Val Ser Leu Arg Asn Ser Ser Leu Val Leu Gly Glu Leu
             100                 105                 110

 cac gag ggt gcc cgt ggc cac ttc cta tgc cag gtt ctg cac gtg gct      384
 His Glu Gly Ala Arg Gly His Phe Leu Cys Gln Val Leu His Val Ala
         115                 120                 125

 ggc ggc cag ctc cac gct gcc tac tcc cac ctc acg ctg gct gtg ctg      432
 Gly Gly Gln Leu His Ala Ala Tyr Ser His Leu Thr Leu Ala Val Leu
     130                 135                 140

 gtg ccg gtg tcc aag cct caa gtg cga ctg agt aac ccg tcc cct gtg      480
 Val Pro Val Ser Lys Pro Gln Val Arg Leu Ser Asn Pro Ser Pro Val
 145                 150                 155                 160

 gag gga gcc tcc gtg gtg gcc acg tgt gca gtg cgg gag ggc aca gag      528
 Glu Gly Ala Ser Val Val Ala Thr Cys Ala Val Arg Glu Gly Thr Glu
                 165                 170                 175

 ccc gtg acc ttt gcc tgg cag cat cgg gca ccc cga ggc ctt gga gag      576
 Pro Val Thr Phe Ala Trp Gln His Arg Ala Pro Arg Gly Leu Gly Glu
             180                 185                 190

 gcc ctg gtg ggg gtc act gag cca cta ttc cag ctg gac cct gtc aac      624
 Ala Leu Val Gly Val Thr Glu Pro Leu Phe Gln Leu Asp Pro Val Asn
         195                 200                 205

 cgg aca cac cta ggg tgg tac atg tgc agc gcc agc aac tcc gtg aac      672
 Arg Thr His Leu Gly Trp Tyr Met Cys Ser Ala Ser Asn Ser Val Asn
     210                 215                 220

 agg ctg agc agt gac ggg gcc ttc ctg gac gtc att tat ggt cct gac      720
 Arg Leu Ser Ser Asp Gly Ala Phe Leu Asp Val Ile Tyr Gly Pro Asp
 225                 230                 235                 240

 aag cct gtg atc acc atg gag ccg ctg gga ctc act gag gag ggc ttc      768
 Lys Pro Val Ile Thr Met Glu Pro Leu Gly Leu Thr Glu Glu Gly Phe
                 245                 250                 255

 tgg gcc agt gag agg gaa gag gtg acc ctg agc tgt ctg gct gcc tcc      816
 Trp Ala Ser Glu Arg Glu Glu Val Thr Leu Ser Cys Leu Ala Ala Ser
             260                 265                 270

 aac cca cct agt cac tat gtg tgg ctc cgt gac cac acg caa gtc cac      864
 Asn Pro Pro Ser His Tyr Val Trp Leu Arg Asp His Thr Gln Val His
         275                 280                 285

 acg ggg cct acc tat gtc atc gcc aga gct ggc cgt gtc cac aca ggc      912
 Thr Gly Pro Thr Tyr Val Ile Ala Arg Ala Gly Arg Val His Thr Gly
     290                 295                 300

 ctg tac acc tgc ctg gcc cgc aac agc tac ctg gac acc cgc acc cag      960
 Leu Tyr Thr Cys Leu Ala Arg Asn Ser Tyr Leu Asp Thr Arg Thr Gln
 305                 310                 315                 320

 act act gtc cag ctc acc atc tac tgg gag cct ctc ggg agg cct acc     1008
 Thr Thr Val Gln Leu Thr Ile Tyr Trp Glu Pro Leu Gly Arg Pro Thr
                 325                 330                 335

 tgc tgg agc aca gcc aca atg ggg gac cag ttc atc atg ctg agc tgc     1056
 Cys Trp Ser Thr Ala Thr Met Gly Asp Gln Phe Ile Met Leu Ser Cys
             340                 345                 350

 gag tgg cct ggc ggc gag ccc cct gcc acg ctg ggc tgg ctt gac gaa     1104
 Glu Trp Pro Gly Gly Glu Pro Pro Ala Thr Leu Gly Trp Leu Asp Glu
         355                 360                 365

 cag cag cag ccc ctg ggc ggc agc agc tcc tcg atg gcc gtt cac ctc     1152
 Gln Gln Gln Pro Leu Gly Gly Ser Ser Ser Ser Met Ala Val His Leu
     370                 375                 380

 ctg cag gcc caa gaa gat ctg gct ggc aga gag ttc acc tgc cgg ggc     1200
 Leu Gln Ala Gln Glu Asp Leu Ala Gly Arg Glu Phe Thr Cys Arg Gly
 385                 390                 395                 400

 act cac ctg ctc agg acc cct gac ccc cac tgc cac ctc cag ctg gaa     1248
 Thr His Leu Leu Arg Thr Pro Asp Pro His Cys His Leu Gln Leu Glu
                 405                 410                 415

 gcc cca cag ctg gac gtg gct gag ccc cgc gtg tca gtg ttg gag ggg     1296
 Ala Pro Gln Leu Asp Val Ala Glu Pro Arg Val Ser Val Leu Glu Gly
             420                 425                 430

 gga gag gcc tgg ctg gag tgc tct ctc cgc ggg ggc aca cca cct gcc     1344
 Gly Glu Ala Trp Leu Glu Cys Ser Leu Arg Gly Gly Thr Pro Pro Ala
         435                 440                 445

 cag ctc ctc tgg ctg ggg cct caa caa caa aaa gtg gac ccc ggc act     1392
 Gln Leu Leu Trp Leu Gly Pro Gln Gln Gln Lys Val Asp Pro Gly Thr
     450                 455                 460

 tca gga ttc atg ctg cac cct gag ggt gcc cag ctg cgc ctg ggc atc     1440
 Ser Gly Phe Met Leu His Pro Glu Gly Ala Gln Leu Arg Leu Gly Ile
 465                 470                 475                 480

 tac gat gct gac ccg gca cac cac agg ggc acc tac caa tgc gtg gcc     1488
 Tyr Asp Ala Asp Pro Ala His His Arg Gly Thr Tyr Gln Cys Val Ala
                 485                 490                 495

 cgc aac gcc gtg ggc aat agc agt cag agt gtg ctg ctg gag gtc ctg     1536
 Arg Asn Ala Val Gly Asn Ser Ser Gln Ser Val Leu Leu Glu Val Leu
             500                 505                 510

 aga tat cca gct cct ccc aat gtc acc atc agc cgc ctg acc tac ggg     1584
 Arg Tyr Pro Ala Pro Pro Asn Val Thr Ile Ser Arg Leu Thr Tyr Gly
         515                 520                 525

 agg cac cgg aga gag gtg cag ctt caa tgg gcc atc tta gga ccc ggg     1632
 Arg His Arg Arg Glu Val Gln Leu Gln Trp Ala Ile Leu Gly Pro Gly
     530                 535                 540

 aac ctg acg ggc ttc ctg gtg cag cgg aag gcc agt gcc ctg ggc cca     1680
 Asn Leu Thr Gly Phe Leu Val Gln Arg Lys Ala Ser Ala Leu Gly Pro
 545                 550                 555                 560

 gga gct ggg gcg tgg gag aca gca gct agt gac atc gag cca gag agc     1728
 Gly Ala Gly Ala Trp Glu Thr Ala Ala Ser Asp Ile Glu Pro Glu Ser
                 565                 570                 575

 cga gga cgg cgg ctg ggg ggc ttg gac ccc ggg gtc ctt tat gcc ttc     1776
 Arg Gly Arg Arg Leu Gly Gly Leu Asp Pro Gly Val Leu Tyr Ala Phe
             580                 585                 590

 cgc atc ctg gct ctg aat cac cac act gca gga cat ccc tct gag gtg     1824
 Arg Ile Leu Ala Leu Asn His His Thr Ala Gly His Pro Ser Glu Val
         595                 600                 605

 aag ata cca gcg gac ccc ccc ttc agc gcc tac cca gcg gtg ttg ggt     1872
 Lys Ile Pro Ala Asp Pro Pro Phe Ser Ala Tyr Pro Ala Val Leu Gly
     610                 615                 620

 gca gca ggc acg gga atg gtg gta gca acg gtg gcc tct cta ctg gtg     1920
 Ala Ala Gly Thr Gly Met Val Val Ala Thr Val Ala Ser Leu Leu Val
 625                 630                 635                 640

 ttc cag tat gct gcc cgg cac cca gag act ttc ccc cgg agc aaa ggc     1968
 Phe Gln Tyr Ala Ala Arg His Pro Glu Thr Phe Pro Arg Ser Lys Gly
                 645                 650                 655

 acc aac aga ggg gtt cca gag aag atg ctg agg cac cgg cag ctt acg     2016
 Thr Asn Arg Gly Val Pro Glu Lys Met Leu Arg His Arg Gln Leu Thr
             660                 665                 670

 aac atc act gac gct gca gtg gtc cga ctc cag gag tcg cag ccc aca     2064
 Asn Ile Thr Asp Ala Ala Val Val Arg Leu Gln Glu Ser Gln Pro Thr
         675                 680                 685

 aga tac gga gca gag gta ctg cag atg tag                             2094
 Arg Tyr Gly Ala Glu Val Leu Gln Met 
     690                 695





      <210> 843
      <211> 774
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (522)..(774)

      <400> 843
 atggatggat ggatggatgg atggatggat ggatgggaca gacgctcagg agagcagaga     60

 gaagaccgag tcaaaatgag aagaatgaaa agacaactaa aggatagggg gcctgcccct    120

 cccataaccc catccttccg gttagcaagc cccgtcacca acctcacctc ctccatcaca    180

 cccacatcct atgggctcta cctccaacat caggccaatg agcagcagca ggccacctgc    240

 accgcagcag acgaagctga cggacctgag cagggggctg gggccctcag gcaccggata    300

 ctccgtgggt ggggccagct ggccaggctg ggcggttgca tccccttcgc tccaccaagc    360

 gaagcagagc gtcccggcca ccagaaccac tgtgccgctg actgtcatgc aatagcggag    420

 ggtggaggcc aagtggctcc cgtcacacat ctggacacag agaaggaggg agaagaggaa    480

 atgggccata tgaaaggtgc tgtggcaagg aagacagagc a    tgt gtg ttg tga     533
                                                  Met Leu Cys Leu
                                                    1

 aca ctc att aga gga tca tcc ctg ctg tgc cag gtg cca tgg cgc tgg      581
 Pro Cys His Ser Thr Phe His Met Ala His Phe Leu Phe Ser Leu Leu
   5                  10                  15                  20

 atg cag aaa gca gga cac atg gaa aga tgg tgt gtt cac aaa gaa ttt      629
 Leu Cys Val Gln Met Cys Asp Gly Ser His Leu Ala Ser Thr Leu Arg
                  25                  30                  35

 gga aga aag cca gat ggt gtc cac tga ctg tgc tgg act ggg cag agc      677
 Tyr Cys Met Thr Val Ser Gly Thr Val Val Leu Val Ala Gly Thr Leu
              40                  45                  50

 atg tga tgg ccc ttg cta cat tgc cct aga caa cct cat tca ctg ccg      725
 Cys Phe Ala Trp Trp Ser Glu Gly Asp Ala Thr Ala Gln Pro Gly Gln
          55                  60                  65

 tga ctt cag tta cta ctt ctc agc tga taa att ttc ata tcc agc cta      773
 Leu Ala Pro Pro Thr Glu Tyr Pro Val Pro Glu Gly Pro Ser Pro Leu
      70                  75                  80

 g                                                                    774
 Leu Arg Ser Val Ser Phe Val Cys Cys Gly Ala Gly Gly Leu Leu Leu 
  85                  90                  95                 100





      <210> 844
      <211> 1182
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (1)..(1182)

      <400> 844
  atg gta tta cat gaa acc ttt cct aaa cat aca ttt ctg atg aac ggc      48
  Met Val Leu His Glu Thr Phe Pro Lys His Thr Phe Leu Met Asn Gly
    1               5                  10                  15

 tta att caa gga gta aag ggt ttg ttg tca ttc ctt agt gcc ccg ctt       96
 Leu Ile Gln Gly Val Lys Gly Leu Leu Ser Phe Leu Ser Ala Pro Leu
              20                  25                  30

 att ggt gct ctt tct gat gtt tgg ggc cga aaa tcc ttc ttg ctg cta      144
 Ile Gly Ala Leu Ser Asp Val Trp Gly Arg Lys Ser Phe Leu Leu Leu
          35                  40                  45

 acg gtg ttt ttc aca tgt gcc cca att cct tta atg aag atc agc cca      192
 Thr Val Phe Phe Thr Cys Ala Pro Ile Pro Leu Met Lys Ile Ser Pro
      50                  55                  60

 tgg tgg tac ttt gct gtt atc tct gtt tct ggg gtt ttt gca gtg act      240
 Trp Trp Tyr Phe Ala Val Ile Ser Val Ser Gly Val Phe Ala Val Thr
  65                  70                  75                  80

 ttt tct gtg gta ttt gca tac gta gca gat ata acc caa gag cat gaa      288
 Phe Ser Val Val Phe Ala Tyr Val Ala Asp Ile Thr Gln Glu His Glu
                  85                  90                  95

 aga agt atg gct tat gga ctg gtt tca gca aca ttt gct gca agt tta      336
 Arg Ser Met Ala Tyr Gly Leu Val Ser Ala Thr Phe Ala Ala Ser Leu
             100                 105                 110

 gtc acc agt cct gca att gga gct tat ctt gga cga gta tat ggg gac      384
 Val Thr Ser Pro Ala Ile Gly Ala Tyr Leu Gly Arg Val Tyr Gly Asp
         115                 120                 125

 agc ttg gtg gtg gtc tta gct aca gca ata gct ttg cta gat att tgt      432
 Ser Leu Val Val Val Leu Ala Thr Ala Ile Ala Leu Leu Asp Ile Cys
     130                 135                 140

 ttt atc ctt gtt gct gtg cca gag tcg ttg cct gag aaa atg cgg cca      480
 Phe Ile Leu Val Ala Val Pro Glu Ser Leu Pro Glu Lys Met Arg Pro
 145                 150                 155                 160

 gca tcc tgg gga gca ccc att tcc tgg gaa caa gct gac cct ttt gcg      528
 Ala Ser Trp Gly Ala Pro Ile Ser Trp Glu Gln Ala Asp Pro Phe Ala
                 165                 170                 175

 ata atg aaa ttt tca cca gaa agt gtt gca gcg ttt ata gca gtc ctt      576
 Ile Met Lys Phe Ser Pro Glu Ser Val Ala Ala Phe Ile Ala Val Leu
             180                 185                 190

 ggc att ctt tcc att att gca cag acc ata gtc ttg agt tta ctt atg      624
 Gly Ile Leu Ser Ile Ile Ala Gln Thr Ile Val Leu Ser Leu Leu Met
         195                 200                 205

 agg tca att gga aat aag aac acc att tta ctg ggt cta gga ttt caa      672
 Arg Ser Ile Gly Asn Lys Asn Thr Ile Leu Leu Gly Leu Gly Phe Gln
     210                 215                 220

 ata tta cag ttg gca tgg tat ggc ttt ggt tca gaa cct tgg atg atg      720
 Ile Leu Gln Leu Ala Trp Tyr Gly Phe Gly Ser Glu Pro Trp Met Met
 225                 230                 235                 240

 tgg gct gct ggg gca gta gca gcc atg tct agc atc acc ttt cct gct      768
 Trp Ala Ala Gly Ala Val Ala Ala Met Ser Ser Ile Thr Phe Pro Ala
                 245                 250                 255

 gtc agt gca ctt gtt tca cga act gct gat gct gat caa cag ggt gtc      816
 Val Ser Ala Leu Val Ser Arg Thr Ala Asp Ala Asp Gln Gln Gly Val
             260                 265                 270

 gtt caa gga atg ata aca gga att cga gga tta tgc aat ggt ctg gga      864
 Val Gln Gly Met Ile Thr Gly Ile Arg Gly Leu Cys Asn Gly Leu Gly
         275                 280                 285

 ccg gcc ctc tat gga ttc att ttc tac ata ttc cat gtg gaa ctt aaa      912
 Pro Ala Leu Tyr Gly Phe Ile Phe Tyr Ile Phe His Val Glu Leu Lys
     290                 295                 300

 gaa ctg cca ata aca gga aca gac ttg gga aca aac aca agc cct cag      960
 Glu Leu Pro Ile Thr Gly Thr Asp Leu Gly Thr Asn Thr Ser Pro Gln
 305                 310                 315                 320

 cac cac ttt gaa cag aat tcc atc atc cct ggc cct ccc ttc cta ttt     1008
 His His Phe Glu Gln Asn Ser Ile Ile Pro Gly Pro Pro Phe Leu Phe
                 325                 330                 335

 gga gcc tgt tca gta ctg ctg gct ctg ctt gtt gcc ttg ttt att ccg     1056
 Gly Ala Cys Ser Val Leu Leu Ala Leu Leu Val Ala Leu Phe Ile Pro
             340                 345                 350

 gaa cat acc aat tta agc tta agg tcc agc agt tgg aga aag cac tgt     1104
 Glu His Thr Asn Leu Ser Leu Arg Ser Ser Ser Trp Arg Lys His Cys
         355                 360                 365

 ggc agt cac agc cat cct cat aat aca caa gcg cca gga gag gcc aaa     1152
 Gly Ser His Ser His Pro His Asn Thr Gln Ala Pro Gly Glu Ala Lys
     370                 375                 380

 gaa cct tta ctc cag gac aca aat gtg tga                             1182
 Glu Pro Leu Leu Gln Asp Thr Asn Val 
 385                 390





      <210> 845
      <211> 771
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (1)..(771)

      <400> 845
  atg tcg ccg ctg ctg ggg ctc cgg tcc gag ctg cag gac acc tgc acc      48
  Met Ser Pro Leu Leu Gly Leu Arg Ser Glu Leu Gln Asp Thr Cys Thr
    1               5                  10                  15

 tcg ctg gga ctg atg ctg tcg gtg gtg ctg ctc atg ggg ctg gcc cgc       96
 Ser Leu Gly Leu Met Leu Ser Val Val Leu Leu Met Gly Leu Ala Arg
              20                  25                  30

 gta gtc gcc cgg cag cag ctg cac agg ccg gtg gcc cac gcc ttc gtc      144
 Val Val Ala Arg Gln Gln Leu His Arg Pro Val Ala His Ala Phe Val
          35                  40                  45

 ctg gag ttt cta gcc acc ttc cag ctc tgc tgc tgc acc cac gag ctg      192
 Leu Glu Phe Leu Ala Thr Phe Gln Leu Cys Cys Cys Thr His Glu Leu
      50                  55                  60

 caa ctg ctg agc gaa cag cac ccc gcg cac ccc acc tgg acg ctg acg      240
 Gln Leu Leu Ser Glu Gln His Pro Ala His Pro Thr Trp Thr Leu Thr
  65                  70                  75                  80

 ctc gtc tac ttc ttc tcg ctt gtg cat ggc ctg act ctg gtg ggc acg      288
 Leu Val Tyr Phe Phe Ser Leu Val His Gly Leu Thr Leu Val Gly Thr
                  85                  90                  95

 tcc agc aac ccg tgc ggc gtg atg atg cag atg atg ctg ggg ggc atg      336
 Ser Ser Asn Pro Cys Gly Val Met Met Gln Met Met Leu Gly Gly Met
             100                 105                 110

 tcc ccc gag acg ggt gcg gtg agg cta ttg gct cag ctg gtt agt gcc      384
 Ser Pro Glu Thr Gly Ala Val Arg Leu Leu Ala Gln Leu Val Ser Ala
         115                 120                 125

 ctg tgc agc agg tac tgc aca agc gcc ttg tgg agc ttg ggt ctg acc      432
 Leu Cys Ser Arg Tyr Cys Thr Ser Ala Leu Trp Ser Leu Gly Leu Thr
     130                 135                 140

 cag tat cac gtc agc gag agg agc ttc gct tgc aag aat ccc atc cga      480
 Gln Tyr His Val Ser Glu Arg Ser Phe Ala Cys Lys Asn Pro Ile Arg
 145                 150                 155                 160

 gtc gac ttg ctc aaa gcg gtc atc aca gag gcc gtc tgc tcc ttt ctc      528
 Val Asp Leu Leu Lys Ala Val Ile Thr Glu Ala Val Cys Ser Phe Leu
                 165                 170                 175

 ttc cac agc gct ctg ctg cac ttc cag gaa gtc cga acc aag ctt cgt      576
 Phe His Ser Ala Leu Leu His Phe Gln Glu Val Arg Thr Lys Leu Arg
             180                 185                 190

 atc cac ctg ctg gct gca ctc atc acc ttt ttg gtc tat gca ggt ttg      624
 Ile His Leu Leu Ala Ala Leu Ile Thr Phe Leu Val Tyr Ala Gly Leu
         195                 200                 205

 tca ttc tca cca aat act tgg cac ttc cag agc ctc tat gac atg agg      672
 Ser Phe Ser Pro Asn Thr Trp His Phe Gln Ser Leu Tyr Asp Met Arg
     210                 215                 220

 cta ctt cat aga gcc ttt act atg ctt cta agt att gtg aaa ctc caa      720
 Leu Leu His Arg Ala Phe Thr Met Leu Leu Ser Ile Val Lys Leu Gln
 225                 230                 235                 240

 gag gag gat ttg gag cac agt ttt tca aac tta cga gat cct ctt gtc      768
 Glu Glu Asp Leu Glu His Ser Phe Ser Asn Leu Arg Asp Pro Leu Val
                 245                 250                 255

 tag                                                                  771
 






      <210> 846
      <211> 2400
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (1)..(2400)

      <400> 846
  atg cct ttc acg tct gga gct gcc ttt ctc ctc cgg cct atc tgg ctg      48
  Met Pro Phe Thr Ser Gly Ala Ala Phe Leu Leu Arg Pro Ile Trp Leu
    1               5                  10                  15

 gct gag gct ttt gga aac aaa aac gaa gcc ttc agc ttg tca gcg cca       96
 Ala Glu Ala Phe Gly Asn Lys Asn Glu Ala Phe Ser Leu Ser Ala Pro
              20                  25                  30

 atg gcc cgt gtg gtt cat tat gtg gac cag ccc ctg cca cgc tgc agc      144
 Met Ala Arg Val Val His Tyr Val Asp Gln Pro Leu Pro Arg Cys Ser
          35                  40                  45

 cga gca ctg ctc acc ctg ggg gca ggc atg cag agg cct tgc ctg cgg      192
 Arg Ala Leu Leu Thr Leu Gly Ala Gly Met Gln Arg Pro Cys Leu Arg
      50                  55                  60

 acc gcc ctg gga acg gcg tct ggg agc ccc gag ggg ctg gcg gga ctc      240
 Thr Ala Leu Gly Thr Ala Ser Gly Ser Pro Glu Gly Leu Ala Gly Leu
  65                  70                  75                  80

 ggg gcc cgg gcc atg cgg cag ccg ccc ccg ccc ctc cgc gac cat ccc      288
 Gly Ala Arg Ala Met Arg Gln Pro Pro Pro Pro Leu Arg Asp His Pro
                  85                  90                  95

 cgg ccc aag cgg gag ccg cag cgg cgt ttc tgc tcc tcg ctg cgc cgg      336
 Arg Pro Lys Arg Glu Pro Gln Arg Arg Phe Cys Ser Ser Leu Arg Arg
             100                 105                 110

 cga ccc cgg acc cgg cac ccc act ccg gcc acg ccc agc ggc gag gac      384
 Arg Pro Arg Thr Arg His Pro Thr Pro Ala Thr Pro Ser Gly Glu Asp
         115                 120                 125

 ccg cca gcc cga gca gca ccc atc gcc ccg cgg ccc ccc gcc agg cct      432
 Pro Pro Ala Arg Ala Ala Pro Ile Ala Pro Arg Pro Pro Ala Arg Pro
     130                 135                 140

 cga ctg gag cga gcc ctg tcc ctg gac gac aag ggc tgg agg agg agg      480
 Arg Leu Glu Arg Ala Leu Ser Leu Asp Asp Lys Gly Trp Arg Arg Arg
 145                 150                 155                 160

 cgt ttt cga ggc agc cag gag gac ctg gaa gcc cgg aat ggg acc agt      528
 Arg Phe Arg Gly Ser Gln Glu Asp Leu Glu Ala Arg Asn Gly Thr Ser
                 165                 170                 175

 ccc tcc agg ggc tca gtg cag agc gag ggc ccc ggg gcc ccc gcc cac      576
 Pro Ser Arg Gly Ser Val Gln Ser Glu Gly Pro Gly Ala Pro Ala His
             180                 185                 190

 agc tgc tcc ccg ccc tgc ctg agc acc tcc ttg cag gaa atc ccc aag      624
 Ser Cys Ser Pro Pro Cys Leu Ser Thr Ser Leu Gln Glu Ile Pro Lys
         195                 200                 205

 tcc cgc ggg gtc ctg agc agt gag aga ggg agc ccg tcc tcg ggg ggt      672
 Ser Arg Gly Val Leu Ser Ser Glu Arg Gly Ser Pro Ser Ser Gly Gly
     210                 215                 220

 aac cct ctc tct ggg gtg gcc agc agc tcc ccg aac ctc ccg cac aga      720
 Asn Pro Leu Ser Gly Val Ala Ser Ser Ser Pro Asn Leu Pro His Arg
 225                 230                 235                 240

 gac gcc gcc gtg gcg ggg agc tcg ccc agg ctg ccc agc ctg ctg ccc      768
 Asp Ala Ala Val Ala Gly Ser Ser Pro Arg Leu Pro Ser Leu Leu Pro
                 245                 250                 255

 ccg cgc cca ccg cct gcc ctg agc ctg gac atc gcc tcc gac tcc ctg      816
 Pro Arg Pro Pro Pro Ala Leu Ser Leu Asp Ile Ala Ser Asp Ser Leu
             260                 265                 270

 agg aca gca aac aag gtc gac tcg gat ctt gca gac tac aag ctc cgc      864
 Arg Thr Ala Asn Lys Val Asp Ser Asp Leu Ala Asp Tyr Lys Leu Arg
         275                 280                 285

 gcg cag ccg ctc ctg gtg cgg gcc cac agc agc ctg ggc ccc ggc cgg      912
 Ala Gln Pro Leu Leu Val Arg Ala His Ser Ser Leu Gly Pro Gly Arg
     290                 295                 300

 ccg cgg agc ccc ctg gcc tgc gac gac tgt tcc ctt cgc tcg gcc aaa      960
 Pro Arg Ser Pro Leu Ala Cys Asp Asp Cys Ser Leu Arg Ser Ala Lys
 305                 310                 315                 320

 tcc tcc ttc agc ctc ctg gcg ccc atc cgc agc aag gac gtc cgc agc     1008
 Ser Ser Phe Ser Leu Leu Ala Pro Ile Arg Ser Lys Asp Val Arg Ser
                 325                 330                 335

 agg agt tac ctg gag ggc agc ctc ctg gcc agc ggg gcc ctg ttg ggg     1056
 Arg Ser Tyr Leu Glu Gly Ser Leu Leu Ala Ser Gly Ala Leu Leu Gly
             340                 345                 350

 gcg gat gag ctg gcc cgc tac ttc cca gac cgg aac gtg gca ctc ttc     1104
 Ala Asp Glu Leu Ala Arg Tyr Phe Pro Asp Arg Asn Val Ala Leu Phe
         355                 360                 365

 gtg gcc acc tgg aac atg cag ggc cag aag gag ctc ccg ccc agc ctg     1152
 Val Ala Thr Trp Asn Met Gln Gly Gln Lys Glu Leu Pro Pro Ser Leu
     370                 375                 380

 gac gag ttc ctg ctc cca gcc gag gcc gac tat gcc cag gac ctg tat     1200
 Asp Glu Phe Leu Leu Pro Ala Glu Ala Asp Tyr Ala Gln Asp Leu Tyr
 385                 390                 395                 400

 gtc atc ggg gtc cag gag ggc tgt tct gac agg cgg gag tgg gag act     1248
 Val Ile Gly Val Gln Glu Gly Cys Ser Asp Arg Arg Glu Trp Glu Thr
                 405                 410                 415

 cgt ctg cag gag acg ctg ggc ccg cac tat gtg ctg ctg tcc tcg gcg     1296
 Arg Leu Gln Glu Thr Leu Gly Pro His Tyr Val Leu Leu Ser Ser Ala
             420                 425                 430

 gcc cac ggc gtg ctc tac atg tcg ctc ttc atc cgc agg gac ctc atc     1344
 Ala His Gly Val Leu Tyr Met Ser Leu Phe Ile Arg Arg Asp Leu Ile
         435                 440                 445

 tgg ttc tgc tca gag gtg gag tgc tcc acg gtg acc aca cgc atc gtg     1392
 Trp Phe Cys Ser Glu Val Glu Cys Ser Thr Val Thr Thr Arg Ile Val
     450                 455                 460

 tct cag atc aag acc aag ggg gcc ttg ggc atc agc ttc acc ttt ttt     1440
 Ser Gln Ile Lys Thr Lys Gly Ala Leu Gly Ile Ser Phe Thr Phe Phe
 465                 470                 475                 480

 ggc act tcc ttc ctc ttc atc acg tcc cac ttc acc tca ggt gac ggg     1488
 Gly Thr Ser Phe Leu Phe Ile Thr Ser His Phe Thr Ser Gly Asp Gly
                 485                 490                 495

 aag gtg gcg gag cgg ctg ctg gac tac acc agg act gta caa gcc ctg     1536
 Lys Val Ala Glu Arg Leu Leu Asp Tyr Thr Arg Thr Val Gln Ala Leu
             500                 505                 510

 gtc ctg ccc aga aat gtg ccc gac acc aac ccc tat cgc tcc agc gca     1584
 Val Leu Pro Arg Asn Val Pro Asp Thr Asn Pro Tyr Arg Ser Ser Ala
         515                 520                 525

 gcg gac gtc acc acc cgc ttc gat gag gtg ttc tgg ttt gga gac ttc     1632
 Ala Asp Val Thr Thr Arg Phe Asp Glu Val Phe Trp Phe Gly Asp Phe
     530                 535                 540

 aac ttc cgc ctg agt ggc ggg cgc aca gtc gtg gac gcc ctc ctg tgc     1680
 Asn Phe Arg Leu Ser Gly Gly Arg Thr Val Val Asp Ala Leu Leu Cys
 545                 550                 555                 560

 cag ggc ctg gtg gtg gac gtg ccg gcg ctg ctg cag cac gac cag ctc     1728
 Gln Gly Leu Val Val Asp Val Pro Ala Leu Leu Gln His Asp Gln Leu
                 565                 570                 575

 atc cgg gag atg cgg aaa ggg tcc atc ttc aag ggc ttc cag gag ccg     1776
 Ile Arg Glu Met Arg Lys Gly Ser Ile Phe Lys Gly Phe Gln Glu Pro
             580                 585                 590

 gac atc cac ttc ctc cca tca tac aag ttt gac atc ggg aag gac acg     1824
 Asp Ile His Phe Leu Pro Ser Tyr Lys Phe Asp Ile Gly Lys Asp Thr
         595                 600                 605

 tac gac agc acc tcc aag cag agg acg ccc tca tac acg agt gct tcc     1872
 Tyr Asp Ser Thr Ser Lys Gln Arg Thr Pro Ser Tyr Thr Ser Ala Ser
     610                 615                 620

 agg gca ggc atc tcc cac agc cgg gaa ccg atg cct ggc gtc agg ggt     1920
 Arg Ala Gly Ile Ser His Ser Arg Glu Pro Met Pro Gly Val Arg Gly
 625                 630                 635                 640

 ctg agc ctg gac ggc ctg gac ttg aaa ctc agc tct gca cct tgg cct     1968
 Leu Ser Leu Asp Gly Leu Asp Leu Lys Leu Ser Ser Ala Pro Trp Pro
                 645                 650                 655

 tgt ggc aag tcc cct ttg gtg gag aac ggc gcc ctc tcc atg ggt gtt     2016
 Cys Gly Lys Ser Pro Leu Val Glu Asn Gly Ala Leu Ser Met Gly Val
             660                 665                 670

 ttc aag gct ggg ccc atg gct gca tct ctg ggc atg tcc cga tat ctg     2064
 Phe Lys Ala Gly Pro Met Ala Ala Ser Leu Gly Met Ser Arg Tyr Leu
         675                 680                 685

 gat atc tgc tgg aag cct caa gaa gcc act gag gca ggg cag ggt agg     2112
 Asp Ile Cys Trp Lys Pro Gln Glu Ala Thr Glu Ala Gly Gln Gly Arg
     690                 695                 700

 agc agc cgc tgt cca cag ggt ctc tcc agc ggc gag gga cag gcc ctg     2160
 Ser Ser Arg Cys Pro Gln Gly Leu Ser Ser Gly Glu Gly Gln Ala Leu
 705                 710                 715                 720

 gcc cag ctg gcc aca gac gcc agg caa caa aat ggg cat gag tgt cag     2208
 Ala Gln Leu Ala Thr Asp Ala Arg Gln Gln Asn Gly His Glu Cys Gln
                 725                 730                 735

 ggg tcc cag aag gct tcc ttg tgg ggg gcg ctt gag aac agc agg gag     2256
 Gly Ser Gln Lys Ala Ser Leu Trp Gly Ala Leu Glu Asn Ser Arg Glu
             740                 745                 750

 gac cgc gtc ttg tac aga agc cgc cac aag ggt gac atc tgt cct gtg     2304
 Asp Arg Val Leu Tyr Arg Ser Arg His Lys Gly Asp Ile Cys Pro Val
         755                 760                 765

 agc tac tct tcc tgc ccc ggg atc aag acg tcc gac cac cgc cct gtg     2352
 Ser Tyr Ser Ser Cys Pro Gly Ile Lys Thr Ser Asp His Arg Pro Val
     770                 775                 780

 tat ggc ctc ttc cgg gtg aaa cat tcc gtt ggc agc tgg caa att tga     2400
 Tyr Gly Leu Phe Arg Val Lys His Ser Val Gly Ser Trp Gln Ile 
 785                 790                 795





      <210> 847
      <211> 1119
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (1)..(1119)

      <400> 847
  atg gag ctc aca tgg tgg gca gtt ctg aca tac atg ggg gtt tgt ggg      48
  Met Glu Leu Thr Trp Trp Ala Val Leu Thr Tyr Met Gly Val Cys Gly
    1               5                  10                  15

 gct gct ctg atg ggc ctg ttc ctt gtc aac agg gca gat ggc aat gct       96
 Ala Ala Leu Met Gly Leu Phe Leu Val Asn Arg Ala Asp Gly Asn Ala
              20                  25                  30

 ggc ctg atg ctc agg aga gag gta gag ggt agg gaa tgg aca gtt gaa      144
 Gly Leu Met Leu Arg Arg Glu Val Glu Gly Arg Glu Trp Thr Val Glu
          35                  40                  45

 agt cat cat cat gga agg gtc att gaa gcc aaa ggt gac ctt gta agt      192
 Ser His His His Gly Arg Val Ile Glu Ala Lys Gly Asp Leu Val Ser
      50                  55                  60

 cac ttc ccc tct ttg ggc ccc agt ttc ttc atc tgt aaa atg gga aag      240
 His Phe Pro Ser Leu Gly Pro Ser Phe Phe Ile Cys Lys Met Gly Lys
  65                  70                  75                  80

 ctg ggc tac ttc tta ttc tat gat tcg atc ttc aac ttt acc tgt ctg      288
 Leu Gly Tyr Phe Leu Phe Tyr Asp Ser Ile Phe Asn Phe Thr Cys Leu
                  85                  90                  95

 aag aat ggg agc ctt aag cag atg aat gca tat acc tcc tta atc tcc      336
 Lys Asn Gly Ser Leu Lys Gln Met Asn Ala Tyr Thr Ser Leu Ile Ser
             100                 105                 110

 act ggc acc atg ggt cct cct act gtc act att ttg ctg aga aga cat      384
 Thr Gly Thr Met Gly Pro Pro Thr Val Thr Ile Leu Leu Arg Arg His
         115                 120                 125

 caa cgc tca aaa gtc ata aga cct gct caa gga tgc atg gct cta tac      432
 Gln Arg Ser Lys Val Ile Arg Pro Ala Gln Gly Cys Met Ala Leu Tyr
     130                 135                 140

 ctg cac cca gaa aca cat cct tct gaa gct cga gtg aga aga cgt gat      480
 Leu His Pro Glu Thr His Pro Ser Glu Ala Arg Val Arg Arg Arg Asp
 145                 150                 155                 160

 gag gag ttg ggc tgc ctg ttg gtg cat ctc aga ttc ctg cag cat ctg      528
 Glu Glu Leu Gly Cys Leu Leu Val His Leu Arg Phe Leu Gln His Leu
                 165                 170                 175

 atc agc tct gca agg aag aga gct tca cgt ctc tgg tca gat ata ttc      576
 Ile Ser Ser Ala Arg Lys Arg Ala Ser Arg Leu Trp Ser Asp Ile Phe
             180                 185                 190

 tct gaa gaa att cgg ttt tat gag ctg gga gaa gaa gcg atg gag atg      624
 Ser Glu Glu Ile Arg Phe Tyr Glu Leu Gly Glu Glu Ala Met Glu Met
         195                 200                 205

 ttt cgg caa gat gaa ggc tac atc aag gag gaa gag cgt cct ctg cct      672
 Phe Arg Gln Asp Glu Gly Tyr Ile Lys Glu Glu Glu Arg Pro Leu Pro
     210                 215                 220

 gaa aat gag ttt cag aga caa gtg tgg ctt ctc ttt gaa tac cca gag      720
 Glu Asn Glu Phe Gln Arg Gln Val Trp Leu Leu Phe Glu Tyr Pro Glu
 225                 230                 235                 240

 agc tca ggg cct gcc agg att ata gct att gtg tct gtc atg gtg att      768
 Ser Ser Gly Pro Ala Arg Ile Ile Ala Ile Val Ser Val Met Val Ile
                 245                 250                 255

 ctg atc tca att gtc agc ttc tgt ctg gaa aca ttg ccc atc ttc cgg      816
 Leu Ile Ser Ile Val Ser Phe Cys Leu Glu Thr Leu Pro Ile Phe Arg
             260                 265                 270

 gat gag aat gaa gac atg cat gct agt ggg gtg acc ttc cac aca tat      864
 Asp Glu Asn Glu Asp Met His Ala Ser Gly Val Thr Phe His Thr Tyr
         275                 280                 285

 tcc aac agc acc atc ggg tac cag cag tcc act tcc ttc aca gac cct      912
 Ser Asn Ser Thr Ile Gly Tyr Gln Gln Ser Thr Ser Phe Thr Asp Pro
     290                 295                 300

 ttc ttc att gta gag aca ctc tgc atc atc tgg ttc tcc ttt gaa tct      960
 Phe Phe Ile Val Glu Thr Leu Cys Ile Ile Trp Phe Ser Phe Glu Ser
 305                 310                 315                 320

 ctt ggt gag gtt ctt tgc ctg tcc cag cga aag ccg gct tct tca cca     1008
 Leu Gly Glu Val Leu Cys Leu Ser Gln Arg Lys Pro Ala Ser Ser Pro
                 325                 330                 335

 aca tac atg aac atc att gac atg ggg gcc atc atc ccc cac cca agc     1056
 Thr Tyr Met Asn Ile Ile Asp Met Gly Ala Ile Ile Pro His Pro Ser
             340                 345                 350

 acc ccg ggg aca caa agg gct gag aag cca caa cac gcg caa aaa ccc     1104
 Thr Pro Gly Thr Gln Arg Ala Glu Lys Pro Gln His Ala Gln Lys Pro
         355                 360                 365

 caa cag gcc atc taa                                                 1119
 Gln Gln Ala Ile 
     370





      <210> 848
      <211> 1605
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (1)..(1605)

      <400> 848
  atg gtc aca cgc gcg ggg gcc gga act gcc gtc gcc ggc gcg gtc gtt      48
  Met Val Thr Arg Ala Gly Ala Gly Thr Ala Val Ala Gly Ala Val Val
    1               5                  10                  15

 gtc gca ttg ctc tcg gcc gca ctc gcg ctg tac ggg ccg cca ctg gac       96
 Val Ala Leu Leu Ser Ala Ala Leu Ala Leu Tyr Gly Pro Pro Leu Asp
              20                  25                  30

 gca gtt tta gaa aga gcg ttt tcg cta cgt aaa gca cat tcg ata aag      144
 Ala Val Leu Glu Arg Ala Phe Ser Leu Arg Lys Ala His Ser Ile Lys
          35                  40                  45

 gat atg gaa aat act ttg cag ctg ggc gca gac ttg tcc cac gtg ttc      192
 Asp Met Glu Asn Thr Leu Gln Leu Gly Ala Asp Leu Ser His Val Phe
      50                  55                  60

 tgt gcc agt gcg gcc gca cct gtg att aag gcc tac agc ccg gag ctg      240
 Cys Ala Ser Ala Ala Ala Pro Val Ile Lys Ala Tyr Ser Pro Glu Leu
  65                  70                  75                  80

 atc gtc cac cca gtt ctt gac agc ccc aat gct gtt cat gag gtg gag      288
 Ile Val His Pro Val Leu Asp Ser Pro Asn Ala Val His Glu Val Glu
                  85                  90                  95

 aag tgg ctg ccc cgg ctg cat gct ctt gtc gta gga cct ggc ttg ggt      336
 Lys Trp Leu Pro Arg Leu His Ala Leu Val Val Gly Pro Gly Leu Gly
             100                 105                 110

 aga gat gat gcg ctt ctc aga aat gtc cag ccc tgg cgc cat gct ctg      384
 Arg Asp Asp Ala Leu Leu Arg Asn Val Gln Pro Trp Arg His Ala Leu
         115                 120                 125

 ctg aca tca ggc tcc cag act ctg gac ctt gca ttc tgg ttc ctg tac      432
 Leu Thr Ser Gly Ser Gln Thr Leu Asp Leu Ala Phe Trp Phe Leu Tyr
     130                 135                 140

 act gtt gcc gtg gtc ttg aga gcc ctc agg tca tct agc gtg ggc tgc      480
 Thr Val Ala Val Val Leu Arg Ala Leu Arg Ser Ser Ser Val Gly Cys
 145                 150                 155                 160

 cgc ctc ctc gtc agc ttc cag ctc gtg tct ggt gcg gag cag agg ctt      528
 Arg Leu Leu Val Ser Phe Gln Leu Val Ser Gly Ala Glu Gln Arg Leu
                 165                 170                 175

 cct act tcg tcg acg ttc ctg aat gag gtc atc atc tgg tgt agg cct      576
 Pro Thr Ser Ser Thr Phe Leu Asn Glu Val Ile Ile Trp Cys Arg Pro
             180                 185                 190

 gaa aac aac ccg att agc atg tat ttt tat gtc cag aat tgg tgg gtt      624
 Glu Asn Asn Pro Ile Ser Met Tyr Phe Tyr Val Gln Asn Trp Trp Val
         195                 200                 205

 ctt ggt ctc act gac ttc aag aat gaa gcc gtg gac cct cgc gga gtg      672
 Leu Gly Leu Thr Asp Phe Lys Asn Glu Ala Val Asp Pro Arg Gly Val
     210                 215                 220

 agg cta cag acc ttc gcg gtg agt gtt aca gct ctt aag gca gcg cgt      720
 Arg Leu Gln Thr Phe Ala Val Ser Val Thr Ala Leu Lys Ala Ala Arg
 225                 230                 235                 240

 ctg gag ttg ttc gtt cct ccc ggt ggg ctc gtg gtc tcg ctg gct tca      768
 Leu Glu Leu Phe Val Pro Pro Gly Gly Leu Val Val Ser Leu Ala Ser
                 245                 250                 255

 gga gtg aag ctg cag atc ttc gcg gtg act gtt aca gct cat aaa agc      816
 Gly Val Lys Leu Gln Ile Phe Ala Val Thr Val Thr Ala His Lys Ser
             260                 265                 270

 agt gtg gac cca aag aac tca gga gcc cag ctg gct tca ccc agt gga      864
 Ser Val Asp Pro Lys Asn Ser Gly Ala Gln Leu Ala Ser Pro Ser Gly
         275                 280                 285

 tcc cgc acc agg gct gca ggt gga gct gcc tgc cag tcc tgc gcc gtg      912
 Ser Arg Thr Arg Ala Ala Gly Gly Ala Ala Cys Gln Ser Cys Ala Val
     290                 295                 300

 cgt tcg cat tcc tca gcc ctt ggg tgg tcg atg gga ctg ggt gcc gtg      960
 Arg Ser His Ser Ser Ala Leu Gly Trp Ser Met Gly Leu Gly Ala Val
 305                 310                 315                 320

 gag cag ggg gtg gtg ctc gtc ggg gag gct cgg gcc gca cag gag ccc     1008
 Glu Gln Gly Val Val Leu Val Gly Glu Ala Arg Ala Ala Gln Glu Pro
                 325                 330                 335

 atg gag ggg ggc att ttg gaa gtg tca aag gcc agg gac atc cct gtt     1056
 Met Glu Gly Gly Ile Leu Glu Val Ser Lys Ala Arg Asp Ile Pro Val
             340                 345                 350

 gtc atc gac gcg gat ggc ctg tgg ctg gtc gct cag cag ccg gcc ctc     1104
 Val Ile Asp Ala Asp Gly Leu Trp Leu Val Ala Gln Gln Pro Ala Leu
         355                 360                 365

 atc cat ggc tac cgg aag gct gtg ctc act ccc aac cac gtg gag ttc     1152
 Ile His Gly Tyr Arg Lys Ala Val Leu Thr Pro Asn His Val Glu Phe
     370                 375                 380

 agc aga ctg tat gac gct gtg ctc aga ggc cct atg gac agc gat gac     1200
 Ser Arg Leu Tyr Asp Ala Val Leu Arg Gly Pro Met Asp Ser Asp Asp
 385                 390                 395                 400

 agc cat gga tct gtg cta aga ctc agc caa gcc ctg ggc aac gtg acg     1248
 Ser His Gly Ser Val Leu Arg Leu Ser Gln Ala Leu Gly Asn Val Thr
                 405                 410                 415

 gtg gtc cag aaa gga gag cgc gac atc ctc tcc aac ggc cag cag ggt     1296
 Val Val Gln Lys Gly Glu Arg Asp Ile Leu Ser Asn Gly Gln Gln Gly
             420                 425                 430

 gag tgg cgg ctg ccc tct gtg cat ggg cca gtg cca gtg ctt gtg tgc     1344
 Glu Trp Arg Leu Pro Ser Val His Gly Pro Val Pro Val Leu Val Cys
         435                 440                 445

 agc cag gaa ggc agc agc cgc agg tgt gga ggg caa ggg gac ctc ctg     1392
 Ser Gln Glu Gly Ser Ser Arg Arg Cys Gly Gly Gln Gly Asp Leu Leu
     450                 455                 460

 tcg ggc tcc ctg ggc gtc ctg gta cac tgg gcg ctc ctt gct gga cca     1440
 Ser Gly Ser Leu Gly Val Leu Val His Trp Ala Leu Leu Ala Gly Pro
 465                 470                 475                 480

 cag aaa aca aat ggg tcc agc cct ctc ctg gtg gcc gcg ttt ggc gcc     1488
 Gln Lys Thr Asn Gly Ser Ser Pro Leu Leu Val Ala Ala Phe Gly Ala
                 485                 490                 495

 tgc tct ctc acc agg cag tgc aac cac caa gcc ttc cag aag cac ggt     1536
 Cys Ser Leu Thr Arg Gln Cys Asn His Gln Ala Phe Gln Lys His Gly
             500                 505                 510

 cgc tcc acc acc acc tcc gac atg atc gcc gag gtg ggg gcc gcc ttc     1584
 Arg Ser Thr Thr Thr Ser Asp Met Ile Ala Glu Val Gly Ala Ala Phe
         515                 520                 525

 agc aag ctc ttt gaa acc tga                                         1605
 Ser Lys Leu Phe Glu Thr 
     530





      <210> 849
      <211> 675
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (1)..(675)

      <400> 849
  atg aat gag att gtg cgg aca aaa gaa ttt gaa gga aac atg act tgg      48
  Met Asn Glu Ile Val Arg Thr Lys Glu Phe Glu Gly Asn Met Thr Trp
    1               5                  10                  15

 aag atc aaa ttg aag agt gca atg tac ttt tca aat atg act gta acc       96
 Lys Ile Lys Leu Lys Ser Ala Met Tyr Phe Ser Asn Met Thr Val Thr
              20                  25                  30

 atg gta gca aac tta gta ccc ttc act ctg acc cta cta tct ttt atg      144
 Met Val Ala Asn Leu Val Pro Phe Thr Leu Thr Leu Leu Ser Phe Met
          35                  40                  45

 ctg tta atc tgt tct ttg tgt aaa cat ctc aag aag atg cag ctc cat      192
 Leu Leu Ile Cys Ser Leu Cys Lys His Leu Lys Lys Met Gln Leu His
      50                  55                  60

 ggt aaa gga tct caa gat ccc agc acc aag gtc cac ata aaa gct ttg      240
 Gly Lys Gly Ser Gln Asp Pro Ser Thr Lys Val His Ile Lys Ala Leu
  65                  70                  75                  80

 caa act gtg atc tcc ttc ctc ttg tta tgt gcc att tac ttt ctg tcc      288
 Gln Thr Val Ile Ser Phe Leu Leu Leu Cys Ala Ile Tyr Phe Leu Ser
                  85                  90                  95

 ata atg ata tca gtt tgg agt ttt gga agt ctg gaa aac aaa cct gtc      336
 Ile Met Ile Ser Val Trp Ser Phe Gly Ser Leu Glu Asn Lys Pro Val
             100                 105                 110

 ttc atg ttc tgc aaa gct att aga ttc agc tat cct tca atc cac cca      384
 Phe Met Phe Cys Lys Ala Ile Arg Phe Ser Tyr Pro Ser Ile His Pro
         115                 120                 125

 ttc atc ctg att tgg gga aac aag aag cta aag cag act ttt ctt tca      432
 Phe Ile Leu Ile Trp Gly Asn Lys Lys Leu Lys Gln Thr Phe Leu Ser
     130                 135                 140

 gtt ttt tgg caa atg agg tac tgg ggt ttc ctt gag gca gaa cta tca      480
 Val Phe Trp Gln Met Arg Tyr Trp Gly Phe Leu Glu Ala Glu Leu Ser
 145                 150                 155                 160

 tct ctg ttg ttc tgt ctt cca tca tcc agt ccc ttg gtg gtg gtc atg      528
 Ser Leu Leu Phe Cys Leu Pro Ser Ser Ser Pro Leu Val Val Val Met
                 165                 170                 175

 aaa gtc ata cct tat gcc cac agt gtg gtg atg cat tca agt ccc aaa      576
 Lys Val Ile Pro Tyr Ala His Ser Val Val Met His Ser Ser Pro Lys
             180                 185                 190

 tgg aat gat gac ctg gat cgg gca agc atc ttt gaa tcc tgc tgg atc      624
 Trp Asn Asp Asp Leu Asp Arg Ala Ser Ile Phe Glu Ser Cys Trp Ile
         195                 200                 205

 atc tgg cac agt ggc cag agc agc ttg gag cag agt cca tat ctt ctg      672
 Ile Trp His Ser Gly Gln Ser Ser Leu Glu Gln Ser Pro Tyr Leu Leu
     210                 215                 220

 tag                                                                  675
 






      <210> 850
      <211> 837
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (1)..(837)

      <400> 850
  atg gca ttc tcc ctc tca tca ctt caa tgt ctg gct ttc tgc att ctg      48
  Met Ala Phe Ser Leu Ser Ser Leu Gln Cys Leu Ala Phe Cys Ile Leu
    1               5                  10                  15

 att ttc tac agt ctg gaa ccc ttg ggg cag ctg gaa ggc tct cct gca       96
 Ile Phe Tyr Ser Leu Glu Pro Leu Gly Gln Leu Glu Gly Ser Pro Ala
              20                  25                  30

 gcc tcc tgc aaa gca aaa gag gtc aca gga gat gcc gcc agg acc cac      144
 Ala Ser Cys Lys Ala Lys Glu Val Thr Gly Asp Ala Ala Arg Thr His
          35                  40                  45

 act gat ttc aag cac tca gaa tgt ggg cag acc ttg aaa cct gat aaa      192
 Thr Asp Phe Lys His Ser Glu Cys Gly Gln Thr Leu Lys Pro Asp Lys
      50                  55                  60

 gtg atg tgg aag aga caa aca cga aac cgg agt cta agg aga gat gag      240
 Val Met Trp Lys Arg Gln Thr Arg Asn Arg Ser Leu Arg Arg Asp Glu
  65                  70                  75                  80

 ggt cag aaa gga agt tca agg gaa gag aag gtg gag gca gac atg ctc      288
 Gly Gln Lys Gly Ser Ser Arg Glu Glu Lys Val Glu Ala Asp Met Leu
                  85                  90                  95

 aag aaa ctg tcc cag aca atg aga ata act aac act cag tgc caa tac      336
 Lys Lys Leu Ser Gln Thr Met Arg Ile Thr Asn Thr Gln Cys Gln Tyr
             100                 105                 110

 agc acc aag aat gtc cat ggc cac ctc acc acc aca tct gca agg gtg      384
 Ser Thr Lys Asn Val His Gly His Leu Thr Thr Thr Ser Ala Arg Val
         115                 120                 125

 aca tca caa gcc atc tgc agc tct gga caa cac agc ccc tgt tgg cct      432
 Thr Ser Gln Ala Ile Cys Ser Ser Gly Gln His Ser Pro Cys Trp Pro
     130                 135                 140

 gac aat gat gcc ctc aac tgc gca atg gac ttc agg act agg gta tgg      480
 Asp Asn Asp Ala Leu Asn Cys Ala Met Asp Phe Arg Thr Arg Val Trp
 145                 150                 155                 160

 aag tgc aca cgc ctt gca agc aat gac gcc atg agt ctg act tcc agt      528
 Lys Cys Thr Arg Leu Ala Ser Asn Asp Ala Met Ser Leu Thr Ser Ser
                 165                 170                 175

 tcc agc ata cga gtt gaa tgg atc aca gca ttt act att gct gct ggg      576
 Ser Ser Ile Arg Val Glu Trp Ile Thr Ala Phe Thr Ile Ala Ala Gly
             180                 185                 190

 aga gct gca act ggt tat cta gct tac aaa aga ttt tat gac aaa gat      624
 Arg Ala Ala Thr Gly Tyr Leu Ala Tyr Lys Arg Phe Tyr Asp Lys Asp
         195                 200                 205

 cat cag aat aaa gct atg atg aac ctt cac atc cag aaa gac aac ccc      672
 His Gln Asn Lys Ala Met Met Asn Leu His Ile Gln Lys Asp Asn Pro
     210                 215                 220

 aag ata gta cat gct ttt gac atg gag gat ttg gaa gat aaa gct gtg      720
 Lys Ile Val His Ala Phe Asp Met Glu Asp Leu Glu Asp Lys Ala Val
 225                 230                 235                 240

 tac tgc cat tgc tgg agg tat aaa aag ttc cca ttc tgt gat ggg tct      768
 Tyr Cys His Cys Trp Arg Tyr Lys Lys Phe Pro Phe Cys Asp Gly Ser
                 245                 250                 255

 cac aca aaa cac aac gaa cag act gga gac aac gtg gga cct ctg atc      816
 His Thr Lys His Asn Glu Gln Thr Gly Asp Asn Val Gly Pro Leu Ile
             260                 265                 270

 atc gag aaa aaa gaa act taa                                          837
 Ile Glu Lys Lys Glu Thr 
         275





      <210> 851
      <211> 2340
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (1)..(2340)

      <400> 851
  atg aga gct gta ctg gac aca gca gac att gcc ata gtg gcc ctg tat      48
  Met Arg Ala Val Leu Asp Thr Ala Asp Ile Ala Ile Val Ala Leu Tyr
    1               5                  10                  15

 ttt atc ctg gtc atg tgc att ggt ttt ttt gcc atg tgg aaa tct aat       96
 Phe Ile Leu Val Met Cys Ile Gly Phe Phe Ala Met Trp Lys Ser Asn
              20                  25                  30

 aga agc acc gtg agt gga tac ttc ctg gcg ggg cgc tct atg acc tgg      144
 Arg Ser Thr Val Ser Gly Tyr Phe Leu Ala Gly Arg Ser Met Thr Trp
          35                  40                  45

 gta aca att ggt gcc tct ctg ttt gtg agc aat att ggg agt gag cac      192
 Val Thr Ile Gly Ala Ser Leu Phe Val Ser Asn Ile Gly Ser Glu His
      50                  55                  60

 ttc att ggg ctg gca gga tct gga gct gca agt gga ttt gca gtg ggc      240
 Phe Ile Gly Leu Ala Gly Ser Gly Ala Ala Ser Gly Phe Ala Val Gly
  65                  70                  75                  80

 gca tgg gaa ttc aat gcc tta ctg ctt tta caa ctt ctg gga tgg gtt      288
 Ala Trp Glu Phe Asn Ala Leu Leu Leu Leu Gln Leu Leu Gly Trp Val
                  85                  90                  95

 ttc atc cca att tac atc cgg tca ggg gta tat acc atg cct gaa tac      336
 Phe Ile Pro Ile Tyr Ile Arg Ser Gly Val Tyr Thr Met Pro Glu Tyr
             100                 105                 110

 ttg tcc aag cga ttt ggt ggc cat agg att cag gtc tat ttt gca gcc      384
 Leu Ser Lys Arg Phe Gly Gly His Arg Ile Gln Val Tyr Phe Ala Ala
         115                 120                 125

 ttg tct ctg att ctc tat att ttc acc aag ctc tcg gtg gat ctg tat      432
 Leu Ser Leu Ile Leu Tyr Ile Phe Thr Lys Leu Ser Val Asp Leu Tyr
     130                 135                 140

 tcg ggt gcc ctt ttt atc cag gag tct ttg ggt tgg aat ctt tat gtg      480
 Ser Gly Ala Leu Phe Ile Gln Glu Ser Leu Gly Trp Asn Leu Tyr Val
 145                 150                 155                 160

 tct gtc atc ctg ctc att ggc atg act gct ttg ctg act gtc acc gga      528
 Ser Val Ile Leu Leu Ile Gly Met Thr Ala Leu Leu Thr Val Thr Gly
                 165                 170                 175

 ggc ctt gtt gca gtg atc tac aca gac act ctg cag gct ctg ctc atg      576
 Gly Leu Val Ala Val Ile Tyr Thr Asp Thr Leu Gln Ala Leu Leu Met
             180                 185                 190

 atc att ggg gca ctt aca ctt atg att att agc ata atg gag att ggc      624
 Ile Ile Gly Ala Leu Thr Leu Met Ile Ile Ser Ile Met Glu Ile Gly
         195                 200                 205

 ggg ttt gag gaa gtt aag aga agg tac atg ttg gcc tca ccc gat gtc      672
 Gly Phe Glu Glu Val Lys Arg Arg Tyr Met Leu Ala Ser Pro Asp Val
     210                 215                 220

 act tcc atc tta ttg aca tac aac ctt tcc aac aca aat tct tgt aat      720
 Thr Ser Ile Leu Leu Thr Tyr Asn Leu Ser Asn Thr Asn Ser Cys Asn
 225                 230                 235                 240

 gtc tcc cct aag aaa gaa gcc ctg aaa atg ctg cgg aat cca aca gat      768
 Val Ser Pro Lys Lys Glu Ala Leu Lys Met Leu Arg Asn Pro Thr Asp
                 245                 250                 255

 gaa gat gtt cct tgg cct gga ttc att ctt ggg cag acc cca gct tca      816
 Glu Asp Val Pro Trp Pro Gly Phe Ile Leu Gly Gln Thr Pro Ala Ser
             260                 265                 270

 gta tgg tac tgg tgt gct gac caa gtc atc gtg cag agg gtc ctt gca      864
 Val Trp Tyr Trp Cys Ala Asp Gln Val Ile Val Gln Arg Val Leu Ala
         275                 280                 285

 gcc aaa aac att gct cat gcc aaa ggc tct act ctt atg gct ggc ttc      912
 Ala Lys Asn Ile Ala His Ala Lys Gly Ser Thr Leu Met Ala Gly Phe
     290                 295                 300

 tta aag ctc ctg cca atg ttt atc ata gtt gtc cca gga atg att tcc      960
 Leu Lys Leu Leu Pro Met Phe Ile Ile Val Val Pro Gly Met Ile Ser
 305                 310                 315                 320

 agg ata ctg ttt act gat gat ata gct tgc atc aac cca gag cac tgc     1008
 Arg Ile Leu Phe Thr Asp Asp Ile Ala Cys Ile Asn Pro Glu His Cys
                 325                 330                 335

 atg ctg gtg tgt gga agc aga gct ggt tgc tcc aat att gct tac cca     1056
 Met Leu Val Cys Gly Ser Arg Ala Gly Cys Ser Asn Ile Ala Tyr Pro
             340                 345                 350

 cgc ctg gtg atg aag ctg gtt cct gtg ggc ctt cgg ggt tta atg atg     1104
 Arg Leu Val Met Lys Leu Val Pro Val Gly Leu Arg Gly Leu Met Met
         355                 360                 365

 gca gtg atg att gca gct ctg atg agt gac tta gac tct atc ttt aac     1152
 Ala Val Met Ile Ala Ala Leu Met Ser Asp Leu Asp Ser Ile Phe Asn
     370                 375                 380

 agt gcc agt acc ata ttc acc ctc gat gtg tac aaa ctt atc cgc aag     1200
 Ser Ala Ser Thr Ile Phe Thr Leu Asp Val Tyr Lys Leu Ile Arg Lys
 385                 390                 395                 400

 agc gca agc tcc cgg gag tta atg att gtg ggg agg ata ttt gtg gca     1248
 Ser Ala Ser Ser Arg Glu Leu Met Ile Val Gly Arg Ile Phe Val Ala
                 405                 410                 415

 ttt atg gtg gtg atc agc ata gca tgg gtg cca atc atc gtg gag atg     1296
 Phe Met Val Val Ile Ser Ile Ala Trp Val Pro Ile Ile Val Glu Met
             420                 425                 430

 caa gga ggc cag atg tac ctt tac att cag gag gta gca gat tac ctg     1344
 Gln Gly Gly Gln Met Tyr Leu Tyr Ile Gln Glu Val Ala Asp Tyr Leu
         435                 440                 445

 aca ccc cca gtg gca gcc ttg ttc ctg ctg gca att ttc tgg aag cgc     1392
 Thr Pro Pro Val Ala Ala Leu Phe Leu Leu Ala Ile Phe Trp Lys Arg
     450                 455                 460

 tgc aat gaa caa ggg gct ttc tat ggt gga atg gct ggc ttt gtt ctt     1440
 Cys Asn Glu Gln Gly Ala Phe Tyr Gly Gly Met Ala Gly Phe Val Leu
 465                 470                 475                 480

 gga gca gtc cgt ttg ata ctg gcc ttt gcc tac cgt gcc cca gaa tgt     1488
 Gly Ala Val Arg Leu Ile Leu Ala Phe Ala Tyr Arg Ala Pro Glu Cys
                 485                 490                 495

 gac caa cct gat aat agg ccg ggc ttc atc aaa gac atc cat tat atg     1536
 Asp Gln Pro Asp Asn Arg Pro Gly Phe Ile Lys Asp Ile His Tyr Met
             500                 505                 510

 tat gtg gcc aca gga ttg ttt tgg gtc acg gga ctc att act gta att     1584
 Tyr Val Ala Thr Gly Leu Phe Trp Val Thr Gly Leu Ile Thr Val Ile
         515                 520                 525

 gtg agc ctt ctc aca cca cct ccc aca aag gaa cag att cga acc acc     1632
 Val Ser Leu Leu Thr Pro Pro Pro Thr Lys Glu Gln Ile Arg Thr Thr
     530                 535                 540

 acc ttt tgg tct aag aag aac ctg gtg gtg aag gag aac tgc tcc cca     1680
 Thr Phe Trp Ser Lys Lys Asn Leu Val Val Lys Glu Asn Cys Ser Pro
 545                 550                 555                 560

 aaa gag gaa cca tac caa atg caa gaa aag agc att ctg aga tgc agt     1728
 Lys Glu Glu Pro Tyr Gln Met Gln Glu Lys Ser Ile Leu Arg Cys Ser
                 565                 570                 575

 gag aat aat gag acc atc aac cac atc att ccc aac ggg aaa tct gaa     1776
 Glu Asn Asn Glu Thr Ile Asn His Ile Ile Pro Asn Gly Lys Ser Glu
             580                 585                 590

 gac agc att aag ggc ctt cag cct gaa gat gtt aat ctg ttg gta acc     1824
 Asp Ser Ile Lys Gly Leu Gln Pro Glu Asp Val Asn Leu Leu Val Thr
         595                 600                 605

 tgc aga gag gag ggc aac cca gtg gca tcc tta ggt cat tca gag gca     1872
 Cys Arg Glu Glu Gly Asn Pro Val Ala Ser Leu Gly His Ser Glu Ala
     610                 615                 620

 gaa aca cca gtt gac gct tac tcc aat ggg caa gca gct ctc atg ggt     1920
 Glu Thr Pro Val Asp Ala Tyr Ser Asn Gly Gln Ala Ala Leu Met Gly
 625                 630                 635                 640

 gag aaa gag aga aag aaa gaa acg gat gat gga ggt cgg tac tgg aag     1968
 Glu Lys Glu Arg Lys Lys Glu Thr Asp Asp Gly Gly Arg Tyr Trp Lys
                 645                 650                 655

 ttc ata gac tgg ttt tgt ggc ttt aaa agt aag agc ctc agc aag agg     2016
 Phe Ile Asp Trp Phe Cys Gly Phe Lys Ser Lys Ser Leu Ser Lys Arg
             660                 665                 670

 agt ctc aga gac ctg atg gaa gag gag gct gtt tgt tta cag atg cta     2064
 Ser Leu Arg Asp Leu Met Glu Glu Glu Ala Val Cys Leu Gln Met Leu
         675                 680                 685

 gaa gag act cgg caa gtt aaa gta ata cta aat att gga ctt ttt gct     2112
 Glu Glu Thr Arg Gln Val Lys Val Ile Leu Asn Ile Gly Leu Phe Ala
     690                 695                 700

 aat gtt att gct aat gtt tct tct cgt att ctt cct ttt gat tcc aat     2160
 Asn Val Ile Ala Asn Val Ser Ser Arg Ile Leu Pro Phe Asp Ser Asn
 705                 710                 715                 720

 gct ggt att gat ggc tta gca ggc act tgg tgc agg ggc ccc ttg gat     2208
 Ala Gly Ile Asp Gly Leu Ala Gly Thr Trp Cys Arg Gly Pro Leu Asp
                 725                 730                 735

 ggg ctt cag aga gcc gtc tgt gca ggt gac tat gaa atg tgt att tct     2256
 Gly Leu Gln Arg Ala Val Cys Ala Gly Asp Tyr Glu Met Cys Ile Ser
             740                 745                 750

 cat cca cct gct ttg agc tta aga ttt aca tct gga gag gtc aac cta     2304
 His Pro Pro Ala Leu Ser Leu Arg Phe Thr Ser Gly Glu Val Asn Leu
         755                 760                 765

 ggg gag cca tgg cat ctg aga ctc agc gtg tct taa                     2340
 Gly Glu Pro Trp His Leu Arg Leu Ser Val Ser 
     770                 775





      <210> 852
      <211> 1782
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (1)..(1782)

      <400> 852
  atg gat gca gcc aca gct cca aag caa gcc tgg ccc cca tgg ccc ccg      48
  Met Asp Ala Ala Thr Ala Pro Lys Gln Ala Trp Pro Pro Trp Pro Pro
    1               5                  10                  15

 ctc ctt ttc ctc ctc ctc cta cct gga ggg agc ggt ggc agc tgc cct       96
 Leu Leu Phe Leu Leu Leu Leu Pro Gly Gly Ser Gly Gly Ser Cys Pro
              20                  25                  30

 gct gtg tgt gac tgc acc tcc cag ccc cag gct gtg ctc tgt ggc cac      144
 Ala Val Cys Asp Cys Thr Ser Gln Pro Gln Ala Val Leu Cys Gly His
          35                  40                  45

 agg caa ctg gag gct gta cct gga gga ctc cca ctg gac act gag ctc      192
 Arg Gln Leu Glu Ala Val Pro Gly Gly Leu Pro Leu Asp Thr Glu Leu
      50                  55                  60

 ctg gac ctg agt ggg aac cgc ctg tgg ggg ctc cag cag gga atg ctc      240
 Leu Asp Leu Ser Gly Asn Arg Leu Trp Gly Leu Gln Gln Gly Met Leu
  65                  70                  75                  80

 tcc cgc ctg agc ctg ctc cag gaa ttg gac ctc agc tac aac cag ctc      288
 Ser Arg Leu Ser Leu Leu Gln Glu Leu Asp Leu Ser Tyr Asn Gln Leu
                  85                  90                  95

 tca acc ctt gag cct ggg gcc ttc cat ggc cta caa agc cta ctc acc      336
 Ser Thr Leu Glu Pro Gly Ala Phe His Gly Leu Gln Ser Leu Leu Thr
             100                 105                 110

 ctg agg ctg cag ggc aat cgg ctc aga atc atg ggg cct ggg gtc ttc      384
 Leu Arg Leu Gln Gly Asn Arg Leu Arg Ile Met Gly Pro Gly Val Phe
         115                 120                 125

 tca ggc ctc tct gct ctg acc ctg ctg gac ctc cgc ctc aac cag att      432
 Ser Gly Leu Ser Ala Leu Thr Leu Leu Asp Leu Arg Leu Asn Gln Ile
     130                 135                 140

 gtt ctc ttc cta gat gga gct ttt ggg gag cta ggc agc ctc cag aag      480
 Val Leu Phe Leu Asp Gly Ala Phe Gly Glu Leu Gly Ser Leu Gln Lys
 145                 150                 155                 160

 ctg gag gtt ggg gac aac cac ctg gta ttt gtg gct ccg ggg gcc ttt      528
 Leu Glu Val Gly Asp Asn His Leu Val Phe Val Ala Pro Gly Ala Phe
                 165                 170                 175

 gca ggg cta gcc aag ttg agc acc ctc acc ctg gag cgc tgc aac ctc      576
 Ala Gly Leu Ala Lys Leu Ser Thr Leu Thr Leu Glu Arg Cys Asn Leu
             180                 185                 190

 agc aca gtg cct ggc cta gcc ctt gcc cgt ctc ccg gca cta gtg gcc      624
 Ser Thr Val Pro Gly Leu Ala Leu Ala Arg Leu Pro Ala Leu Val Ala
         195                 200                 205

 cta agg ctt aga gaa ctg gat att ggg agg ctg cca gct ggg gcc ctg      672
 Leu Arg Leu Arg Glu Leu Asp Ile Gly Arg Leu Pro Ala Gly Ala Leu
     210                 215                 220

 cgg ggg ctg ggg cag ctc aag gag ctg gag atc cac ctc tgg cca tct      720
 Arg Gly Leu Gly Gln Leu Lys Glu Leu Glu Ile His Leu Trp Pro Ser
 225                 230                 235                 240

 ctg gag gct ctg gac cct ggg agc ctg gtt ggg ctc aat ctc agc agc      768
 Leu Glu Ala Leu Asp Pro Gly Ser Leu Val Gly Leu Asn Leu Ser Ser
                 245                 250                 255

 ctg gcc atc act cgc tgc aat ctg agc tcg gtg ccc ttc caa gca ctg      816
 Leu Ala Ile Thr Arg Cys Asn Leu Ser Ser Val Pro Phe Gln Ala Leu
             260                 265                 270

 tac cac ctc agc ttc ctc agg gtc ctg gat ctg tcc cag aat ccc atc      864
 Tyr His Leu Ser Phe Leu Arg Val Leu Asp Leu Ser Gln Asn Pro Ile
         275                 280                 285

 tca gcc atc cca gcc cga agg ctc agc ccc ctg gtg cgg ctc cag gag      912
 Ser Ala Ile Pro Ala Arg Arg Leu Ser Pro Leu Val Arg Leu Gln Glu
     290                 295                 300

 cta cgc ctg tca ggg gca tgc ctc acc tcc att gct gcc cat gcc ttc      960
 Leu Arg Leu Ser Gly Ala Cys Leu Thr Ser Ile Ala Ala His Ala Phe
 305                 310                 315                 320

 cat ggc ttg act gcc ttc cac ctc ctg gat gtg gca gat aac gcc ctt     1008
 His Gly Leu Thr Ala Phe His Leu Leu Asp Val Ala Asp Asn Ala Leu
                 325                 330                 335

 cag aca cta gag gaa aca gct ttc cct tct cca gac aaa ctg gtc acc     1056
 Gln Thr Leu Glu Glu Thr Ala Phe Pro Ser Pro Asp Lys Leu Val Thr
             340                 345                 350

 ttg agg ctg tct ggc aac ccc cta acc tgt gac tgc cgc ctc ctc tgg     1104
 Leu Arg Leu Ser Gly Asn Pro Leu Thr Cys Asp Cys Arg Leu Leu Trp
         355                 360                 365

 ctg ctc cgg ctc cgc cgc cac ctg gac ttt ggc atg tcc ccc cct gcc     1152
 Leu Leu Arg Leu Arg Arg His Leu Asp Phe Gly Met Ser Pro Pro Ala
     370                 375                 380

 tgt gct ggc ccc cat cat gtc cag ggg aag agc ctg aag gag ttt tca     1200
 Cys Ala Gly Pro His His Val Gln Gly Lys Ser Leu Lys Glu Phe Ser
 385                 390                 395                 400

 gac atc ctg cct cca ggg cac ttc acc tgc aaa cca gcc ctg atc cga     1248
 Asp Ile Leu Pro Pro Gly His Phe Thr Cys Lys Pro Ala Leu Ile Arg
                 405                 410                 415

 aag tcg ggg cct cga tgg gtc att gca gag gag ggc ggg cat gcg gtt     1296
 Lys Ser Gly Pro Arg Trp Val Ile Ala Glu Glu Gly Gly His Ala Val
             420                 425                 430

 ttc tcc tgc tct gga gat gga gac cca gcc ccc act gtc tcc tgg atg     1344
 Phe Ser Cys Ser Gly Asp Gly Asp Pro Ala Pro Thr Val Ser Trp Met
         435                 440                 445

 agg cct cat ggg gct tgg ctg ggc agg gct ggg aga gta agg gtc cta     1392
 Arg Pro His Gly Ala Trp Leu Gly Arg Ala Gly Arg Val Arg Val Leu
     450                 455                 460

 gag gat ggg aca ctg gag atc cgc tca gtg cag cta cgg gac aga ggg     1440
 Glu Asp Gly Thr Leu Glu Ile Arg Ser Val Gln Leu Arg Asp Arg Gly
 465                 470                 475                 480

 gcc tat gtc tgt gtg gtt agc aat gtc gct ggg aat gac tcc ctg agg     1488
 Ala Tyr Val Cys Val Val Ser Asn Val Ala Gly Asn Asp Ser Leu Arg
                 485                 490                 495

 acc tgg ctg gaa gtc atc cag gtg gaa cca cca aac ggc aca ctt tct     1536
 Thr Trp Leu Glu Val Ile Gln Val Glu Pro Pro Asn Gly Thr Leu Ser
             500                 505                 510

 gac ccc aac atc acc gtg cca ggg atc cca ggg cct ttt ttt ctg gat     1584
 Asp Pro Asn Ile Thr Val Pro Gly Ile Pro Gly Pro Phe Phe Leu Asp
         515                 520                 525

 agc aga ggt gtg gcc atg gtg ctg gca gtc ggc ttc ctc ccc ttc ctc     1632
 Ser Arg Gly Val Ala Met Val Leu Ala Val Gly Phe Leu Pro Phe Leu
     530                 535                 540

 acc tca gtg acc ctc tgc ttt ggc ctg att gcc ctt tgg agc aag ggc     1680
 Thr Ser Val Thr Leu Cys Phe Gly Leu Ile Ala Leu Trp Ser Lys Gly
 545                 550                 555                 560

 aaa ggt cgg gtc aaa cat cac atg acc ttt gac ttt gtg gca cct cgg     1728
 Lys Gly Arg Val Lys His His Met Thr Phe Asp Phe Val Ala Pro Arg
                 565                 570                 575

 ccc tct ggg gat aaa aac tct ggg ggt aac cgg gtc act gcc aag ctc     1776
 Pro Ser Gly Asp Lys Asn Ser Gly Gly Asn Arg Val Thr Ala Lys Leu
             580                 585                 590

 ttc tga                                                             1782
 Phe 






      <210> 853
      <211> 2133
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (1)..(2133)

      <400> 853
  atg cta gct ttc cta ctt act atc tta gct tca att ttc tcc ttt gta      48
  Met Leu Ala Phe Leu Leu Thr Ile Leu Ala Ser Ile Phe Ser Phe Val
    1               5                  10                  15

 aat ggg ggt ggt gat aat agc aac ttg tcc agc cag ctt ctg gcc cag       96
 Asn Gly Gly Gly Asp Asn Ser Asn Leu Ser Ser Gln Leu Leu Ala Gln
              20                  25                  30

 gaa cac aac tac agc tcc cct gcg ggt cac cat cct cac gta ctg tac      144
 Glu His Asn Tyr Ser Ser Pro Ala Gly His His Pro His Val Leu Tyr
          35                  40                  45

 aaa agg aca gca gag gag aag atc cag cgg tac cgt ggc tac ccc ggc      192
 Lys Arg Thr Ala Glu Glu Lys Ile Gln Arg Tyr Arg Gly Tyr Pro Gly
      50                  55                  60

 tct ggc cgg aat tat cct ggt tac tcc cca agt cac att ccc cat gca      240
 Ser Gly Arg Asn Tyr Pro Gly Tyr Ser Pro Ser His Ile Pro His Ala
  65                  70                  75                  80

 tct cag agt cga gag aca gag tat cac cat cga agg ttg caa aag cag      288
 Ser Gln Ser Arg Glu Thr Glu Tyr His His Arg Arg Leu Gln Lys Gln
                  85                  90                  95

 cat ttt tgt gga cga cgc aag aaa tgt ata tat tct cta ata tcc ctt      336
 His Phe Cys Gly Arg Arg Lys Lys Cys Ile Tyr Ser Leu Ile Ser Leu
             100                 105                 110

 cca aat gct ctt ctg ttc atc gta gat gct ccc aag cct ccc aca gag      384
 Pro Asn Ala Leu Leu Phe Ile Val Asp Ala Pro Lys Pro Pro Thr Glu
         115                 120                 125

 gac acc tat cta agg ttt gat gaa tat ggg agc tct ggg cga ccc aga      432
 Asp Thr Tyr Leu Arg Phe Asp Glu Tyr Gly Ser Ser Gly Arg Pro Arg
     130                 135                 140

 aga tca gct gga aaa tca caa aag ggc ctc aat gtg gaa acc ctc gtg      480
 Arg Ser Ala Gly Lys Ser Gln Lys Gly Leu Asn Val Glu Thr Leu Val
 145                 150                 155                 160

 gtg gca gac aag aaa atg gtg gaa aag cat ggc aag gga aat gtc acc      528
 Val Ala Asp Lys Lys Met Val Glu Lys His Gly Lys Gly Asn Val Thr
                 165                 170                 175

 aca tac att ctc aca gta atg aac atg gtt tct ggc cta ttt aaa gat      576
 Thr Tyr Ile Leu Thr Val Met Asn Met Val Ser Gly Leu Phe Lys Asp
             180                 185                 190

 ggg act att gga agt gac ata aac gtg gtt gtg gtg agc cta att ctt      624
 Gly Thr Ile Gly Ser Asp Ile Asn Val Val Val Val Ser Leu Ile Leu
         195                 200                 205

 ctg gaa caa gaa cct gga gga tta ttg atc aac cat cat gca gac cag      672
 Leu Glu Gln Glu Pro Gly Gly Leu Leu Ile Asn His His Ala Asp Gln
     210                 215                 220

 tct ctg aat agt ttt tgt caa tgg cag tct gcc ctc att gga aag aat      720
 Ser Leu Asn Ser Phe Cys Gln Trp Gln Ser Ala Leu Ile Gly Lys Asn
 225                 230                 235                 240

 ggc aag aga cat gat cat gcc atc tta cta aca gga ttt gat att tgt      768
 Gly Lys Arg His Asp His Ala Ile Leu Leu Thr Gly Phe Asp Ile Cys
                 245                 250                 255

 tct tgg aag aat gaa cca tgt gac act cta ggg ttt gcc ccc atc agt      816
 Ser Trp Lys Asn Glu Pro Cys Asp Thr Leu Gly Phe Ala Pro Ile Ser
             260                 265                 270

 gga atg tgc tct aag tac cga agt tgt acc atc aat gag gac aca gga      864
 Gly Met Cys Ser Lys Tyr Arg Ser Cys Thr Ile Asn Glu Asp Thr Gly
         275                 280                 285

 ctt ggc ctt gcc ttc acc atc gct cat gag tca ggg cac aac ttt ggt      912
 Leu Gly Leu Ala Phe Thr Ile Ala His Glu Ser Gly His Asn Phe Gly
     290                 295                 300

 atg att cac gat gga gaa ggg aat ccc tgc aga aag gct gaa ggc aat      960
 Met Ile His Asp Gly Glu Gly Asn Pro Cys Arg Lys Ala Glu Gly Asn
 305                 310                 315                 320

 atc atg tct ccc aca ctg acc gga aac aat gga gtg ttt tca tgg tct     1008
 Ile Met Ser Pro Thr Leu Thr Gly Asn Asn Gly Val Phe Ser Trp Ser
                 325                 330                 335

 tcc tgc agc cgc cag tat ctc aag aaa ttc ctc agc aca cct cag gcg     1056
 Ser Cys Ser Arg Gln Tyr Leu Lys Lys Phe Leu Ser Thr Pro Gln Ala
             340                 345                 350

 ggg tgt cta gtg gat gag ccc aag caa gca gga cag tat aaa tat ccg     1104
 Gly Cys Leu Val Asp Glu Pro Lys Gln Ala Gly Gln Tyr Lys Tyr Pro
         355                 360                 365

 gac aaa cta cca gga cag att tat gat gct gac aca cag tgt aaa tgg     1152
 Asp Lys Leu Pro Gly Gln Ile Tyr Asp Ala Asp Thr Gln Cys Lys Trp
     370                 375                 380

 caa ttt gga gca aaa gcc aag tta tgc agc ctt ggt ttt gtg aag tgg     1200
 Gln Phe Gly Ala Lys Ala Lys Leu Cys Ser Leu Gly Phe Val Lys Trp
 385                 390                 395                 400

 tgt cgg caa ggc cag tgc gta aag ttt ggg gag ctc ggg ccc cgg ccc     1248
 Cys Arg Gln Gly Gln Cys Val Lys Phe Gly Glu Leu Gly Pro Arg Pro
                 405                 410                 415

 atc cac ggc cag tgg tcc gcc tgg tcg aag tgg tca gaa tgt tcc cgg     1296
 Ile His Gly Gln Trp Ser Ala Trp Ser Lys Trp Ser Glu Cys Ser Arg
             420                 425                 430

 aca tgt ggt gga gga gtc aag ttc cag gag aga cac tgc aat aac ccc     1344
 Thr Cys Gly Gly Gly Val Lys Phe Gln Glu Arg His Cys Asn Asn Pro
         435                 440                 445

 aag gac ctt ccc aat gtc ctt ctt cag gca ttt gtt ctc aat cgg gtt     1392
 Lys Asp Leu Pro Asn Val Leu Leu Gln Ala Phe Val Leu Asn Arg Val
     450                 455                 460

 aga act gac acg cct cag tat ggt ggc tta ttc tgt cca ggt tct agc     1440
 Arg Thr Asp Thr Pro Gln Tyr Gly Gly Leu Phe Cys Pro Gly Ser Ser
 465                 470                 475                 480

 cgt att tat cag ctg tgc aat att aac cct tgc aat gaa aat agc ttg     1488
 Arg Ile Tyr Gln Leu Cys Asn Ile Asn Pro Cys Asn Glu Asn Ser Leu
                 485                 490                 495

 gat ttt cgg gct caa cag tgt gca gaa tat aac agc aaa cct ttc cgt     1536
 Asp Phe Arg Ala Gln Gln Cys Ala Glu Tyr Asn Ser Lys Pro Phe Arg
             500                 505                 510

 gga tgg ttc tac cag tgg aaa ccc tat aca aaa gtg gaa gag gaa gat     1584
 Gly Trp Phe Tyr Gln Trp Lys Pro Tyr Thr Lys Val Glu Glu Glu Asp
         515                 520                 525

 cga tgc aaa ctg tac tgc aag gct gag aac ttt gaa ttt ttt ttt gca     1632
 Arg Cys Lys Leu Tyr Cys Lys Ala Glu Asn Phe Glu Phe Phe Phe Ala
     530                 535                 540

 atg tcc ggc aaa gtg aaa gat gga act ccc tgc tcc cca aac aaa aat     1680
 Met Ser Gly Lys Val Lys Asp Gly Thr Pro Cys Ser Pro Asn Lys Asn
 545                 550                 555                 560

 gat gtt tgt att gac ggg gtt tgt gaa cta gtg gga tgt gat cat gaa     1728
 Asp Val Cys Ile Asp Gly Val Cys Glu Leu Val Gly Cys Asp His Glu
                 565                 570                 575

 cta ggc tct aaa gca gtt tca gat gct tgt ggc gtt tgc aaa ggt gat     1776
 Leu Gly Ser Lys Ala Val Ser Asp Ala Cys Gly Val Cys Lys Gly Asp
             580                 585                 590

 aat tca act tgc aag ttt tat aaa ggc ctg tac ctc aac cag cat aaa     1824
 Asn Ser Thr Cys Lys Phe Tyr Lys Gly Leu Tyr Leu Asn Gln His Lys
         595                 600                 605

 gca aat gaa tat tat ccg gtg gtc ctc att cca gct ggc gcc cga agc     1872
 Ala Asn Glu Tyr Tyr Pro Val Val Leu Ile Pro Ala Gly Ala Arg Ser
     610                 615                 620

 atc gaa atc cag gag ctg cag gtt tcc tcc agt tac ctc gca gtt cga     1920
 Ile Glu Ile Gln Glu Leu Gln Val Ser Ser Ser Tyr Leu Ala Val Arg
 625                 630                 635                 640

 agc ctc agt caa aag tat tac ctc acc ggg ggc tgg agc atc gac tgg     1968
 Ser Leu Ser Gln Lys Tyr Tyr Leu Thr Gly Gly Trp Ser Ile Asp Trp
                 645                 650                 655

 cct ggg gag ttc ccc ttc gct ggg acc acg ttt gaa tac cag cgc tct     2016
 Pro Gly Glu Phe Pro Phe Ala Gly Thr Thr Phe Glu Tyr Gln Arg Ser
             660                 665                 670

 ttc aac cgc ccg gaa cgt ctg tac gcg cca ggg ccc aca aat gag acg     2064
 Phe Asn Arg Pro Glu Arg Leu Tyr Ala Pro Gly Pro Thr Asn Glu Thr
         675                 680                 685

 ctg gtc ttt gaa gta agc ccc ttc tgt gta ttc agt tct cag tgc ttc     2112
 Leu Val Phe Glu Val Ser Pro Phe Cys Val Phe Ser Ser Gln Cys Phe
     690                 695                 700

 ttg cta cat tta tat cgt tga                                         2133
 Leu Leu His Leu Tyr Arg 
 705                 710





      <210> 854
      <211> 447
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (1)..(447)

      <400> 854
  atg gac aca agt ccc ctg tgt ttc tcc att ctg ttg gtt tta tgc atc      48
  Met Asp Thr Ser Pro Leu Cys Phe Ser Ile Leu Leu Val Leu Cys Ile
    1               5                  10                  15

 ttt atc caa tca agt gcc ctt gga caa agc ctg aaa cca gat ggc tac       96
 Phe Ile Gln Ser Ser Ala Leu Gly Gln Ser Leu Lys Pro Asp Gly Tyr
              20                  25                  30

 tca gac gcc agt ctg cga gca ccc cac gct cag ctg ctc cat gct tca      144
 Ser Asp Ala Ser Leu Arg Ala Pro His Ala Gln Leu Leu His Ala Ser
          35                  40                  45

 gcc acc atg caa ccc atc tgg ata atg gac tgt tat gaa gca tgc acc      192
 Ala Thr Met Gln Pro Ile Trp Ile Met Asp Cys Tyr Glu Ala Cys Thr
      50                  55                  60

 ctc att ccg cat tct cgt tca aac ctg ctc atg gaa gtc ctg gaa tgt      240
 Leu Ile Pro His Ser Arg Ser Asn Leu Leu Met Glu Val Leu Glu Cys
  65                  70                  75                  80

 gtt ttc tcc ctc atc ctc agt ccc acc cat cac aca gcc tgc act gga      288
 Val Phe Ser Leu Ile Leu Ser Pro Thr His His Thr Ala Cys Thr Gly
                  85                  90                  95

 tca tcc aag tta cat gcc aaa tgt ctg tac ccc tct gtg tcc aag aaa      336
 Ser Ser Lys Leu His Ala Lys Cys Leu Tyr Pro Ser Val Ser Lys Lys
             100                 105                 110

 gaa agg aaa gaa tcc atc agg tct ttt ctg tgt cct gag att gcg cag      384
 Glu Arg Lys Glu Ser Ile Arg Ser Phe Leu Cys Pro Glu Ile Ala Gln
         115                 120                 125

 gta ttc acc cgc tcc act ccc atc tcc ttg acc tct ttc ttg ccc tgt      432
 Val Phe Thr Arg Ser Thr Pro Ile Ser Leu Thr Ser Phe Leu Pro Cys
     130                 135                 140

 ttc tcg gcg acc tag                                                  447
 Phe Ser Ala Thr 
 145





      <210> 855
      <211> 1092
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (1)..(1092)

      <400> 855
  atg ggg ctg ctg ctc atg atc ctg gcg tcg gcc gtg ctg ggt tcc ttc      48
  Met Gly Leu Leu Leu Met Ile Leu Ala Ser Ala Val Leu Gly Ser Phe
    1               5                  10                  15

 ctc acg ctc ctc gcc cag ttc ttc ctg ctg tac cgc aga cag ccc gag       96
 Leu Thr Leu Leu Ala Gln Phe Phe Leu Leu Tyr Arg Arg Gln Pro Glu
              20                  25                  30

 ccg ccg gcg gac gag gcc gcc cgc gcg ggc gag ggc ttc cgc tac atc      144
 Pro Pro Ala Asp Glu Ala Ala Arg Ala Gly Glu Gly Phe Arg Tyr Ile
          35                  40                  45

 aag cca gtg ccg ggc ctg ctc cta agg gag tac ctt tat ggc ggc ggc      192
 Lys Pro Val Pro Gly Leu Leu Leu Arg Glu Tyr Leu Tyr Gly Gly Gly
      50                  55                  60

 cgg gat gag gag ccc tcc gga gcg gcc cct gag ggc ggc gcg acc ccc      240
 Arg Asp Glu Glu Pro Ser Gly Ala Ala Pro Glu Gly Gly Ala Thr Pro
  65                  70                  75                  80

 acc gcg gcc ccc gag acc ccc gcc ccg ccg acg cgg gag act tgc tac      288
 Thr Ala Ala Pro Glu Thr Pro Ala Pro Pro Thr Arg Glu Thr Cys Tyr
                  85                  90                  95

 ttc ctc aac gcc acc atc cta ttc ctg ttc cgg gag ttg cgg gac acc      336
 Phe Leu Asn Ala Thr Ile Leu Phe Leu Phe Arg Glu Leu Arg Asp Thr
             100                 105                 110

 gcg ctg acc cgc cgc tgg gtc acc aag aag atc aag gtg gag ttc gag      384
 Ala Leu Thr Arg Arg Trp Val Thr Lys Lys Ile Lys Val Glu Phe Glu
         115                 120                 125

 gag ctg ctg cag acc aag acg gcc ggg cgc ctg ctg gag ggg ctg agc      432
 Glu Leu Leu Gln Thr Lys Thr Ala Gly Arg Leu Leu Glu Gly Leu Ser
     130                 135                 140

 ctg cgg gac gtg ttc ctg ggc gag acg gtg ccc ttc atc aag acc atc      480
 Leu Arg Asp Val Phe Leu Gly Glu Thr Val Pro Phe Ile Lys Thr Ile
 145                 150                 155                 160

 cgg ctc gtg cgg cca gtc gtg ccc tcg gcc acc ggg gag ccc gat ggc      528
 Arg Leu Val Arg Pro Val Val Pro Ser Ala Thr Gly Glu Pro Asp Gly
                 165                 170                 175

 cct gaa ggg gag gcg ctg ccc gcc gcc tgc ccc gag gag ctg gcc ttc      576
 Pro Glu Gly Glu Ala Leu Pro Ala Ala Cys Pro Glu Glu Leu Ala Phe
             180                 185                 190

 gag gcg gag gtg gag tac aac ggg ggc ttc cac ctg gcc atc gac gtg      624
 Glu Ala Glu Val Glu Tyr Asn Gly Gly Phe His Leu Ala Ile Asp Val
         195                 200                 205

 gac ctg gtc ttc ggc aag tcc gcc tac ttg ttt gtc aag ctg tcc cgc      672
 Asp Leu Val Phe Gly Lys Ser Ala Tyr Leu Phe Val Lys Leu Ser Arg
     210                 215                 220

 gtg gtg gga agg ctg cgc ttg gtc ttt acg cgc gtg ccc ttc acc cac      720
 Val Val Gly Arg Leu Arg Leu Val Phe Thr Arg Val Pro Phe Thr His
 225                 230                 235                 240

 tgg ttc ttc tcc ttc gtg gaa gac ccg ctg atc gac ttc gag gtg cgc      768
 Trp Phe Phe Ser Phe Val Glu Asp Pro Leu Ile Asp Phe Glu Val Arg
                 245                 250                 255

 tcc cag ttt gaa ggg cgg ccc atg ccc cag ctc acc tcc atc atc gtc      816
 Ser Gln Phe Glu Gly Arg Pro Met Pro Gln Leu Thr Ser Ile Ile Val
             260                 265                 270

 aac cag ctc aag aag atc atc aag cgc aag cac acc cta ccg aat tac      864
 Asn Gln Leu Lys Lys Ile Ile Lys Arg Lys His Thr Leu Pro Asn Tyr
         275                 280                 285

 aag atc agc atc ccc ttg gcc gct ttg aga aat tgt tcc tgg aca cag      912
 Lys Ile Ser Ile Pro Leu Ala Ala Leu Arg Asn Cys Ser Trp Thr Gln
     290                 295                 300

 tac acg cgt gaa gag tgt gct tat agc cca gaa gca att tgg cgc aca      960
 Tyr Thr Arg Glu Glu Cys Ala Tyr Ser Pro Glu Ala Ile Trp Arg Thr
 305                 310                 315                 320

 gga gga cag ctt cag ccc cct atg agt tca tct ctg ccc caa cca atc     1008
 Gly Gly Gln Leu Gln Pro Pro Met Ser Ser Ser Leu Pro Gln Pro Ile
                 325                 330                 335

 agc agc aag ccc ctg tta gct ggc cac ccc act cct ttc ccc aaa ctg     1056
 Ser Ser Lys Pro Leu Leu Ala Gly His Pro Thr Pro Phe Pro Lys Leu
             340                 345                 350

 cct ttg aaa aac cct tcc cct acg agc ttt gaa tga                     1092
 Pro Leu Lys Asn Pro Ser Pro Thr Ser Phe Glu 
         355                 360





      <210> 856
      <211> 498
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (1)..(498)

      <400> 856
  atg gac ctc gcg gga ctg ctg aag tct cag ttc ctg tgc cac ctg gtc      48
  Met Asp Leu Ala Gly Leu Leu Lys Ser Gln Phe Leu Cys His Leu Val
    1               5                  10                  15

 ttc tgc tac gtc ttt att gcc tca ggg cta atc atc aac acc att cag       96
 Phe Cys Tyr Val Phe Ile Ala Ser Gly Leu Ile Ile Asn Thr Ile Gln
              20                  25                  30

 ctc ttc act ctc ctc ctc tgg ccc att aac aag cag ctc ttc cgg aag      144
 Leu Phe Thr Leu Leu Leu Trp Pro Ile Asn Lys Gln Leu Phe Arg Lys
          35                  40                  45

 atc aac tgc aga ctg tcc tat tgc atc tca agc cgg cat gtg gtt ctc      192
 Ile Asn Cys Arg Leu Ser Tyr Cys Ile Ser Ser Arg His Val Val Leu
      50                  55                  60

 ttg cca gaa gaa caa ggc acc aac tca tca gac aca gac acc agc cat      240
 Leu Pro Glu Glu Gln Gly Thr Asn Ser Ser Asp Thr Asp Thr Ser His
  65                  70                  75                  80

 cac agg gca ttc ccg gtg aat gca tac gtg ttc aat tgg tct ttg cag      288
 His Arg Ala Phe Pro Val Asn Ala Tyr Val Phe Asn Trp Ser Leu Gln
                  85                  90                  95

 gca tca cat aga aca tgc tct acg cta caa gtg acc tac agt att cag      336
 Ala Ser His Arg Thr Cys Ser Thr Leu Gln Val Thr Tyr Ser Ile Gln
             100                 105                 110

 tac agt cac atg ctg tac agc ttt gat cac atg atg aag ttc tgc aac      384
 Tyr Ser His Met Leu Tyr Ser Phe Asp His Met Met Lys Phe Cys Asn
         115                 120                 125

 att tgc ttt tat act aca ggc atc atg ggc ttg ctg agt gaa ctg tta      432
 Ile Cys Phe Tyr Thr Thr Gly Ile Met Gly Leu Leu Ser Glu Leu Leu
     130                 135                 140

 cat gaa gtg tgc gct agg aag cgc ttt gag ctt tta aag atc tct ggc      480
 His Glu Val Cys Ala Arg Lys Arg Phe Glu Leu Leu Lys Ile Ser Gly
 145                 150                 155                 160

 tac tgt aca aac ttc tga                                              498
 Tyr Cys Thr Asn Phe 
                 165





      <210> 857
      <211> 888
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (1)..(888)

      <400> 857
  atg cct ggg aag aga ggc ttg ggc tgg tgg tgg gcc cgg ctg ccc ctt      48
  Met Pro Gly Lys Arg Gly Leu Gly Trp Trp Trp Ala Arg Leu Pro Leu
    1               5                  10                  15

 tgc ctg ctc ctc agc ctt tac ggc ccc tgg atg cct tcc tcc ctg gga       96
 Cys Leu Leu Leu Ser Leu Tyr Gly Pro Trp Met Pro Ser Ser Leu Gly
              20                  25                  30

 aag ccc aaa ggc cac cct cac atg aat tcc atc cgc ata gat ggg gac      144
 Lys Pro Lys Gly His Pro His Met Asn Ser Ile Arg Ile Asp Gly Asp
          35                  40                  45

 atc aca ctg gga ggc ctg ttc ccg gtg cat ggc cgg ggc tca gag ggc      192
 Ile Thr Leu Gly Gly Leu Phe Pro Val His Gly Arg Gly Ser Glu Gly
      50                  55                  60

 aag ccc tgt gga gaa ctt aag aag gaa aag ggc atc cac cgg ctg gag      240
 Lys Pro Cys Gly Glu Leu Lys Lys Glu Lys Gly Ile His Arg Leu Glu
  65                  70                  75                  80

 gcc atg ctg ttc gcc ctg gat cgc atc aac aac gac ccg gac ctg ctg      288
 Ala Met Leu Phe Ala Leu Asp Arg Ile Asn Asn Asp Pro Asp Leu Leu
                  85                  90                  95

 cct aac atc acg ctg ggc gcc cgc att ctg gac acc tgc tcc agg gac      336
 Pro Asn Ile Thr Leu Gly Ala Arg Ile Leu Asp Thr Cys Ser Arg Asp
             100                 105                 110

 acc cat gcc ctc gag cag tcg ctg acc ttt gtg cag gcg ctc atc gag      384
 Thr His Ala Leu Glu Gln Ser Leu Thr Phe Val Gln Ala Leu Ile Glu
         115                 120                 125

 aag gat ggc aca gag gtc cgc tgt ggc agt ggc ggc cca ccc atc atc      432
 Lys Asp Gly Thr Glu Val Arg Cys Gly Ser Gly Gly Pro Pro Ile Ile
     130                 135                 140

 acc aag cct gaa cgt gtg gtg ggt gtc atc ggt gct tca ggg agc tcg      480
 Thr Lys Pro Glu Arg Val Val Gly Val Ile Gly Ala Ser Gly Ser Ser
 145                 150                 155                 160

 gtc tcc atc atg gtg gcc aac atc ctt cgc ctc ttc aag gtc agt gcc      528
 Val Ser Ile Met Val Ala Asn Ile Leu Arg Leu Phe Lys Val Ser Ala
                 165                 170                 175

 ttg gtt ggt ccc ctg agg tgc tct tcc ccc aac gga ctc tgc ccg ccc      576
 Leu Val Gly Pro Leu Arg Cys Ser Ser Pro Asn Gly Leu Cys Pro Pro
             180                 185                 190

 cac ttc agg gtg cca ggc ctg gcc gac cag ccc ctt ttt cct cct ttt      624
 His Phe Arg Val Pro Gly Leu Ala Asp Gln Pro Leu Phe Pro Pro Phe
         195                 200                 205

 ttc ctc act cta agg gac agt ttt ttc ctc aga gca gtg tct gag aat      672
 Phe Leu Thr Leu Arg Asp Ser Phe Phe Leu Arg Ala Val Ser Glu Asn
     210                 215                 220

 ttg ggg cag ctc ttc ctg gtt tca gta tgt tgt ctt gtg gtc tca gca      720
 Leu Gly Gln Leu Phe Leu Val Ser Val Cys Cys Leu Val Val Ser Ala
 225                 230                 235                 240

 cag gca cag cag atg aaa ggc atc ggg acc cag cct tgt ggc gct gac      768
 Gln Ala Gln Gln Met Lys Gly Ile Gly Thr Gln Pro Cys Gly Ala Asp
                 245                 250                 255

 cga ggt gct gaa aca gca cct gcc gct gga ggc tcg gtg agc aac tcc      816
 Arg Gly Ala Glu Thr Ala Pro Ala Ala Gly Gly Ser Val Ser Asn Ser
             260                 265                 270

 act cct ctc tgg gga att ctg tac cag gag gaa aag gat gtt ctg gag      864
 Thr Pro Leu Trp Gly Ile Leu Tyr Gln Glu Glu Lys Asp Val Leu Glu
         275                 280                 285

 aac gac aga ggg agg agg aga tag                                      888
 Asn Asp Arg Gly Arg Arg Arg 
     290                 295





      <210> 858
      <211> 1518
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (1)..(1518)

      <400> 858
  atg gcc aca tca aca cct tct aga att ggt aca ttt gtg ttc tgg aca      48
  Met Ala Thr Ser Thr Pro Ser Arg Ile Gly Thr Phe Val Phe Trp Thr
    1               5                  10                  15

 ctg gac ttc acg ccc tta act tcc gcc acg cac cca gcg ccc acc ctc       96
 Leu Asp Phe Thr Pro Leu Thr Ser Ala Thr His Pro Ala Pro Thr Leu
              20                  25                  30

 aga ccc gac ctt ctc aac ctg gac atc gtt cgt cca gag ctc tac agc      144
 Arg Pro Asp Leu Leu Asn Leu Asp Ile Val Arg Pro Glu Leu Tyr Ser
          35                  40                  45

 tgc tgc ctc ggt act gac cga ggg ttc cca gag ctg tct cac cat tgc      192
 Cys Cys Leu Gly Thr Asp Arg Gly Phe Pro Glu Leu Ser His His Cys
      50                  55                  60

 aaa aac gtt ata gca aca gcc tct gat tac gac atg gct gag atc acc      240
 Lys Asn Val Ile Ala Thr Ala Ser Asp Tyr Asp Met Ala Glu Ile Thr
  65                  70                  75                  80

 aat atc cga cct agc ttt gat gtg tca ccg gtg gtg gcc ggc ctc atc      288
 Asn Ile Arg Pro Ser Phe Asp Val Ser Pro Val Val Ala Gly Leu Ile
                  85                  90                  95

 ggg gcc tct gtg ctg gtg gtg tgt gtc tcg gtg acc gtc ttt gtc tgg      336
 Gly Ala Ser Val Leu Val Val Cys Val Ser Val Thr Val Phe Val Trp
             100                 105                 110

 tca tgc tgc cac cag cag gca gag aag aag cag aag aac cca cca tac      384
 Ser Cys Cys His Gln Gln Ala Glu Lys Lys Gln Lys Asn Pro Pro Tyr
         115                 120                 125

 aag ttt att cac atg ctc aaa ggc atc agc ata tac cca gag acc ctc      432
 Lys Phe Ile His Met Leu Lys Gly Ile Ser Ile Tyr Pro Glu Thr Leu
     130                 135                 140

 agc aac aag aag aaa atc atc aaa gtg cgg aga gac aaa gat ggt cct      480
 Ser Asn Lys Lys Lys Ile Ile Lys Val Arg Arg Asp Lys Asp Gly Pro
 145                 150                 155                 160

 ggg agg gaa ggt gga cgt agg aac ctg ttg gtg gac gca gca gag gct      528
 Gly Arg Glu Gly Gly Arg Arg Asn Leu Leu Val Asp Ala Ala Glu Ala
                 165                 170                 175

 ggc ctg cta agc cga gac aaa gat ccc agg ggg cct agc tct gga tct      576
 Gly Leu Leu Ser Arg Asp Lys Asp Pro Arg Gly Pro Ser Ser Gly Ser
             180                 185                 190

 tgt ata gac caa tta ccc atc aaa atg gac tat ggg gaa gaa cta agg      624
 Cys Ile Asp Gln Leu Pro Ile Lys Met Asp Tyr Gly Glu Glu Leu Arg
         195                 200                 205

 agc cct att aca agc ctg acc cct ggg gag agc aaa acc acc tct cca      672
 Ser Pro Ile Thr Ser Leu Thr Pro Gly Glu Ser Lys Thr Thr Ser Pro
     210                 215                 220

 tca tct cca gag gag gat gtc atg cta gga tcc ctc acc ttc tca gtg      720
 Ser Ser Pro Glu Glu Asp Val Met Leu Gly Ser Leu Thr Phe Ser Val
 225                 230                 235                 240

 gac tat aac ttc ccg aaa aaa gcc ctg gtg gtg aca atc cag gag gcc      768
 Asp Tyr Asn Phe Pro Lys Lys Ala Leu Val Val Thr Ile Gln Glu Ala
                 245                 250                 255

 cat ggg ctg cca gtg atg gat gac cag acc cag gga tct gac ccc tac      816
 His Gly Leu Pro Val Met Asp Asp Gln Thr Gln Gly Ser Asp Pro Tyr
             260                 265                 270

 atc aaa atg acc atc ctt cct gac aaa cgg cat cgg gtg aag acc aga      864
 Ile Lys Met Thr Ile Leu Pro Asp Lys Arg His Arg Val Lys Thr Arg
         275                 280                 285

 gtg ctg cgg aag acc ctg gac cct gtg ttt gac gag acc ttc acc ttc      912
 Val Leu Arg Lys Thr Leu Asp Pro Val Phe Asp Glu Thr Phe Thr Phe
     290                 295                 300

 tat ggc atc ccc tac agc cag ctg cag gac ctg gtg ctg cac ttc ctt      960
 Tyr Gly Ile Pro Tyr Ser Gln Leu Gln Asp Leu Val Leu His Phe Leu
 305                 310                 315                 320

 gtc ctc agc ttt gac cgc ttc tct cgg gat gat gtc att ggc gag gtc     1008
 Val Leu Ser Phe Asp Arg Phe Ser Arg Asp Asp Val Ile Gly Glu Val
                 325                 330                 335

 atg gtg cca ctg gca ggg gtg gac ccc agc aca ggc aag gta caa ctg     1056
 Met Val Pro Leu Ala Gly Val Asp Pro Ser Thr Gly Lys Val Gln Leu
             340                 345                 350

 acc agg gac atc atc aaa agg aat atc cag aag tgc atc agc aga ggg     1104
 Thr Arg Asp Ile Ile Lys Arg Asn Ile Gln Lys Cys Ile Ser Arg Gly
         355                 360                 365

 gag ctc cag gtg tct ctg tca tat cag cct gtg gca cag aga atg aca     1152
 Glu Leu Gln Val Ser Leu Ser Tyr Gln Pro Val Ala Gln Arg Met Thr
     370                 375                 380

 gtg gtg gtc ctc aaa gcc aga cac ttg ccg aag atg gat atc acc ggt     1200
 Val Val Val Leu Lys Ala Arg His Leu Pro Lys Met Asp Ile Thr Gly
 385                 390                 395                 400

 ctc tca gat cct tat gtc aag gtg aac gtc tac tac ggc aga aag cgc     1248
 Leu Ser Asp Pro Tyr Val Lys Val Asn Val Tyr Tyr Gly Arg Lys Arg
                 405                 410                 415

 att gcc aag aag aaa acc cat gtg aag aag tgc act ttg aac ccc atc     1296
 Ile Ala Lys Lys Lys Thr His Val Lys Lys Cys Thr Leu Asn Pro Ile
             420                 425                 430

 ttc aat gaa tct ttc atc tac gac atc ccc act gac ctc ctg cct gat     1344
 Phe Asn Glu Ser Phe Ile Tyr Asp Ile Pro Thr Asp Leu Leu Pro Asp
         435                 440                 445

 atc agc atc gag ttc ctc gtt atc gac ttc gat cgc acc acc aag aat     1392
 Ile Ser Ile Glu Phe Leu Val Ile Asp Phe Asp Arg Thr Thr Lys Asn
     450                 455                 460

 gag gtg gtg ggg agg ctg atc ctg ggg gca cac agt gtc aca gcc agt     1440
 Glu Val Val Gly Arg Leu Ile Leu Gly Ala His Ser Val Thr Ala Ser
 465                 470                 475                 480

 ggt gct gaa cac tgg aga gag gtc tgc gag agc ccc cgc aag cct gtg     1488
 Gly Ala Glu His Trp Arg Glu Val Cys Glu Ser Pro Arg Lys Pro Val
                 485                 490                 495

 gcc aag tgg cac agt ctg agc gag tac taa                             1518
 Ala Lys Trp His Ser Leu Ser Glu Tyr 
             500                 505





      <210> 859
      <211> 1188
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (1)..(1188)

      <400> 859
  atg atc ctg ctg aat aat tgc cag atg ctg ctg gcc ctg tac gaa tcc      48
  Met Ile Leu Leu Asn Asn Cys Gln Met Leu Leu Ala Leu Tyr Glu Ser
    1               5                  10                  15

 ctg gcc gtg agc att cct gag tcc ctg aag gaa ccc ctt caa cat gga       96
 Leu Ala Val Ser Ile Pro Glu Ser Leu Lys Glu Pro Leu Gln His Gly
              20                  25                  30

 ggt gct ggt gga ctc ctg gcc cga gta tca gat agt tat tat cca acc      144
 Gly Ala Gly Gly Leu Leu Ala Arg Val Ser Asp Ser Tyr Tyr Pro Thr
          35                  40                  45

 acc aaa aca ggt ctt caa gaa agt tta ggt gag ggg ata aga gca gct      192
 Thr Lys Thr Gly Leu Gln Glu Ser Leu Gly Glu Gly Ile Arg Ala Ala
      50                  55                  60

 gca ttt tca aag tca gtg aag gta gag cat tca aga gca ttc ctc tgt      240
 Ala Phe Ser Lys Ser Val Lys Val Glu His Ser Arg Ala Phe Leu Cys
  65                  70                  75                  80

 att atg gaa gat atc ctg aag ctc aat gcc tgc aat aaa agc aag ctt      288
 Ile Met Glu Asp Ile Leu Lys Leu Asn Ala Cys Asn Lys Ser Lys Leu
                  85                  90                  95

 gga agt agg gat gag ata ggc cac cca gat gat gaa ttt gag aga aaa      336
 Gly Ser Arg Asp Glu Ile Gly His Pro Asp Asp Glu Phe Glu Arg Lys
             100                 105                 110

 gaa tct cca gag aat caa gtg ggc tgg cct tgt ggc ctc tgc tat gga      384
 Glu Ser Pro Glu Asn Gln Val Gly Trp Pro Cys Gly Leu Cys Tyr Gly
         115                 120                 125

 aat gac act tgt tgt gcc tcc ttt ctc cta ctc ttt ctt act tcc tcg      432
 Asn Asp Thr Cys Cys Ala Ser Phe Leu Leu Leu Phe Leu Thr Ser Ser
     130                 135                 140

 tca tta gtg aag cac agc aca ggg caa ggt gtt gcc tgc aag tat ggt      480
 Ser Leu Val Lys His Ser Thr Gly Gln Gly Val Ala Cys Lys Tyr Gly
 145                 150                 155                 160

 tat aag ttc agc gct tgg tgt ttg cag cac tgc tat ctt aag ggg tca      528
 Tyr Lys Phe Ser Ala Trp Cys Leu Gln His Cys Tyr Leu Lys Gly Ser
                 165                 170                 175

 ggg gca ttc ctg gga gaa gtg act act aag agt gct ggc atc ttg tct      576
 Gly Ala Phe Leu Gly Glu Val Thr Thr Lys Ser Ala Gly Ile Leu Ser
             180                 185                 190

 cta agt cta gag gct cct ggt ccc cat cat gat cat cac cta tca ggg      624
 Leu Ser Leu Glu Ala Pro Gly Pro His His Asp His His Leu Ser Gly
         195                 200                 205

 gcc agc act gct gat ata gaa gct aaa aag aaa tca ttt agg cag tta      672
 Ala Ser Thr Ala Asp Ile Glu Ala Lys Lys Lys Ser Phe Arg Gln Leu
     210                 215                 220

 atg tgg gtt agt tct ctg gcg cca tca gct ggc agc acg cgg gaa tat      720
 Met Trp Val Ser Ser Leu Ala Pro Ser Ala Gly Ser Thr Arg Glu Tyr
 225                 230                 235                 240

 acc aaa cgc gga aac gcg cct tcg cct gcc ctg agt aac tgc aaa tcc      768
 Thr Lys Arg Gly Asn Ala Pro Ser Pro Ala Leu Ser Asn Cys Lys Ser
                 245                 250                 255

 agg gct gaa ctg gca ttg tct gtg ttc gcc agc ccc tcc acg aag ttg      816
 Arg Ala Glu Leu Ala Leu Ser Val Phe Ala Ser Pro Ser Thr Lys Leu
             260                 265                 270

 gat cat ttg cgg agc agg cca agt ccc tct aga cct cac gca gac gcg      864
 Asp His Leu Arg Ser Arg Pro Ser Pro Ser Arg Pro His Ala Asp Ala
         275                 280                 285

 ggt gca gcc tgc tct gcg act tgc agt cag ctg gaa gct ggg cct ctg      912
 Gly Ala Ala Cys Ser Ala Thr Cys Ser Gln Leu Glu Ala Gly Pro Leu
     290                 295                 300

 cat cat cag ggt gga gct ctc tct gct gct gcc gct gga tcc cgc ctg      960
 His His Gln Gly Gly Ala Leu Ser Ala Ala Ala Ala Gly Ser Arg Leu
 305                 310                 315                 320

 gat gca cgt ccc gcc acc gcc gcc gac cca tca gcg gca gaa ggg cag     1008
 Asp Ala Arg Pro Ala Thr Ala Ala Asp Pro Ser Ala Ala Glu Gly Gln
                 325                 330                 335

 caa tgg cca cac acc gaa gca cct tgg cgg gct att ccc ctt gca gct     1056
 Gln Trp Pro His Thr Glu Ala Pro Trp Arg Ala Ile Pro Leu Ala Ala
             340                 345                 350

 ctc ctc agc gcg ctg ctc cca ctc gca atc aaa agg cgg aaa aag cgc     1104
 Leu Leu Ser Ala Leu Leu Pro Leu Ala Ile Lys Arg Arg Lys Lys Arg
         355                 360                 365

 gaa acc gcc agg cat ctc cca tac cca ccc ggc tgc cgc gca acc cct     1152
 Glu Thr Ala Arg His Leu Pro Tyr Pro Pro Gly Cys Arg Ala Thr Pro
     370                 375                 380

 cct tgg ctt cca ctg gga gac agg gga cgc cga tga                     1188
 Pro Trp Leu Pro Leu Gly Asp Arg Gly Arg Arg 
 385                 390                 395





      <210> 860
      <211> 4065
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (1)..(4065)

      <400> 860
  atg atg caa ctt ctg caa ctt ctg ctg ggg ctt ttg ggg cca ggt ggc      48
  Met Met Gln Leu Leu Gln Leu Leu Leu Gly Leu Leu Gly Pro Gly Gly
    1               5                  10                  15

 tac tta ttt ctt tta ggg gat tgt cag gag gtg acc act ctc acg gtg       96
 Tyr Leu Phe Leu Leu Gly Asp Cys Gln Glu Val Thr Thr Leu Thr Val
              20                  25                  30

 aaa tac caa gtg tca gag gaa gtg cca tct ggt aca gtg atc ggg aag      144
 Lys Tyr Gln Val Ser Glu Glu Val Pro Ser Gly Thr Val Ile Gly Lys
          35                  40                  45

 ctg tcc cag gaa ctg ggc cgg gag gag agg cgg agg caa gct ggg gct      192
 Leu Ser Gln Glu Leu Gly Arg Glu Glu Arg Arg Arg Gln Ala Gly Ala
      50                  55                  60

 gcc ttc cag gtg ttg cag ctg cct cag gcg ctc ccc att cag gtg gac      240
 Ala Phe Gln Val Leu Gln Leu Pro Gln Ala Leu Pro Ile Gln Val Asp
  65                  70                  75                  80

 tct gag gaa ggc ttg ctc agc aca ggc agg cgg ctg gat cga gag cag      288
 Ser Glu Glu Gly Leu Leu Ser Thr Gly Arg Arg Leu Asp Arg Glu Gln
                  85                  90                  95

 ctg tgc cga cag tgg gat ccc tgc ctg gtt tcc ttt gat gtg ctt gcc      336
 Leu Cys Arg Gln Trp Asp Pro Cys Leu Val Ser Phe Asp Val Leu Ala
             100                 105                 110

 aca ggg gat ttg gct ctg atc cat gtg gag atc caa gtg ctg gac atc      384
 Thr Gly Asp Leu Ala Leu Ile His Val Glu Ile Gln Val Leu Asp Ile
         115                 120                 125

 aat gac cac cag cca cgg ttt ccc aaa ggc gag cag gag ctg gaa atc      432
 Asn Asp His Gln Pro Arg Phe Pro Lys Gly Glu Gln Glu Leu Glu Ile
     130                 135                 140

 tct gag agc gcc tct ctg cga acc cgg atc ccc ctg gac aga gct ctt      480
 Ser Glu Ser Ala Ser Leu Arg Thr Arg Ile Pro Leu Asp Arg Ala Leu
 145                 150                 155                 160

 gac cca gac aca ggc cct aac acc ctg cac acc tac act ctg tct ccc      528
 Asp Pro Asp Thr Gly Pro Asn Thr Leu His Thr Tyr Thr Leu Ser Pro
                 165                 170                 175

 agt gag cac ttt gcc ttg gat gtc att gtg ggc cct gat gag acc aaa      576
 Ser Glu His Phe Ala Leu Asp Val Ile Val Gly Pro Asp Glu Thr Lys
             180                 185                 190

 cat gca gaa ctc ata gtg gtg aag gag ctg gac agg gaa atc cat tca      624
 His Ala Glu Leu Ile Val Val Lys Glu Leu Asp Arg Glu Ile His Ser
         195                 200                 205

 ttt ttt gat ctg gtg tta act gcc tat gac aat ggg aac ccc ccc aag      672
 Phe Phe Asp Leu Val Leu Thr Ala Tyr Asp Asn Gly Asn Pro Pro Lys
     210                 215                 220

 tca ggt acc agc ttg gtc aag gtc aac gtc ttg gac tcc aat gac aat      720
 Ser Gly Thr Ser Leu Val Lys Val Asn Val Leu Asp Ser Asn Asp Asn
 225                 230                 235                 240

 agc cct gcg ttt gct gag agt tca ctg gca ctg gaa atc caa gaa gat      768
 Ser Pro Ala Phe Ala Glu Ser Ser Leu Ala Leu Glu Ile Gln Glu Asp
                 245                 250                 255

 gct gca cct ggt acg ctt ctc ata aaa ctg acc gcc aca gac cct gac      816
 Ala Ala Pro Gly Thr Leu Leu Ile Lys Leu Thr Ala Thr Asp Pro Asp
             260                 265                 270

 caa ggc ccc aat ggg gag gtg gag ttc ttc ctc agt aag cac atg cct      864
 Gln Gly Pro Asn Gly Glu Val Glu Phe Phe Leu Ser Lys His Met Pro
         275                 280                 285

 cca gag gtg ctg gac acc ttc agt att gat gcc aag aca ggc cag gtc      912
 Pro Glu Val Leu Asp Thr Phe Ser Ile Asp Ala Lys Thr Gly Gln Val
     290                 295                 300

 att ctg cgt cga cct cta gac tat gaa aag aac cct gcc tac gag gtg      960
 Ile Leu Arg Arg Pro Leu Asp Tyr Glu Lys Asn Pro Ala Tyr Glu Val
 305                 310                 315                 320

 gat gtt cag gca agg gac ctg ggt ccc aat cct atc cca gcc cat tgc     1008
 Asp Val Gln Ala Arg Asp Leu Gly Pro Asn Pro Ile Pro Ala His Cys
                 325                 330                 335

 aaa gtt ctc atc aag gtt ctg gat gtc aat gac aac atc cca agc atc     1056
 Lys Val Leu Ile Lys Val Leu Asp Val Asn Asp Asn Ile Pro Ser Ile
             340                 345                 350

 cac gtc aca tgg gcc tcc cag cca tca ctg gtg tca gaa gct ctt ccc     1104
 His Val Thr Trp Ala Ser Gln Pro Ser Leu Val Ser Glu Ala Leu Pro
         355                 360                 365

 aag gac agt ttt att gct ctt gtc atg gca gat gac ttg gat tca gga     1152
 Lys Asp Ser Phe Ile Ala Leu Val Met Ala Asp Asp Leu Asp Ser Gly
     370                 375                 380

 cac aat ggt ttg gtc cac tgc tgg ctg agc caa gag ctg ggc cac ttc     1200
 His Asn Gly Leu Val His Cys Trp Leu Ser Gln Glu Leu Gly His Phe
 385                 390                 395                 400

 agg ctg aaa aga act aat ggc aac aca tac atg ttg cta acc aat gcc     1248
 Arg Leu Lys Arg Thr Asn Gly Asn Thr Tyr Met Leu Leu Thr Asn Ala
                 405                 410                 415

 aca ctg gac aga gag cag tgg ccc aaa tat acc ctc act ctg tta gcc     1296
 Thr Leu Asp Arg Glu Gln Trp Pro Lys Tyr Thr Leu Thr Leu Leu Ala
             420                 425                 430

 caa gac caa gga ctc cag ccc tta tca gcc aag aaa cag ctc agc att     1344
 Gln Asp Gln Gly Leu Gln Pro Leu Ser Ala Lys Lys Gln Leu Ser Ile
         435                 440                 445

 cag atc agt gac atc aac gac aat gca cct gtg ttt gag aaa agc agg     1392
 Gln Ile Ser Asp Ile Asn Asp Asn Ala Pro Val Phe Glu Lys Ser Arg
     450                 455                 460

 tat gaa gtc tcc acg cgg gaa aac aac tta ccc tct ctt cac ctc att     1440
 Tyr Glu Val Ser Thr Arg Glu Asn Asn Leu Pro Ser Leu His Leu Ile
 465                 470                 475                 480

 acc atc aag gct cat gat gca gac ttg ggc att aat gga aaa gtc tca     1488
 Thr Ile Lys Ala His Asp Ala Asp Leu Gly Ile Asn Gly Lys Val Ser
                 485                 490                 495

 tac cgc atc cag gac tcc cca gtt gct cac tta gta gct att gac tcc     1536
 Tyr Arg Ile Gln Asp Ser Pro Val Ala His Leu Val Ala Ile Asp Ser
             500                 505                 510

 aac aca gga gag gtc act gct cag agg tca ctg aac tat gaa gag atg     1584
 Asn Thr Gly Glu Val Thr Ala Gln Arg Ser Leu Asn Tyr Glu Glu Met
         515                 520                 525

 gcc ggc ttt gag ttc cag gtg atc gca gag gac agc ggg caa ccc atg     1632
 Ala Gly Phe Glu Phe Gln Val Ile Ala Glu Asp Ser Gly Gln Pro Met
     530                 535                 540

 ctt gca tcc agt gtc tct gtg tgg gtc agc ctc ttg gat gcc aat gat     1680
 Leu Ala Ser Ser Val Ser Val Trp Val Ser Leu Leu Asp Ala Asn Asp
 545                 550                 555                 560

 aat gcc cca gag gtg gtc cag cct gtg ctc agc gat gga aaa gcc agc     1728
 Asn Ala Pro Glu Val Val Gln Pro Val Leu Ser Asp Gly Lys Ala Ser
                 565                 570                 575

 ctc tcc gtg ctt gtg aat gcc tcc aca ggc cac ctg ctg gtg ccc atc     1776
 Leu Ser Val Leu Val Asn Ala Ser Thr Gly His Leu Leu Val Pro Ile
             580                 585                 590

 gag act ccc aat ggc ttg ggc cca gcg ggc act gac aca cct cca ctg     1824
 Glu Thr Pro Asn Gly Leu Gly Pro Ala Gly Thr Asp Thr Pro Pro Leu
         595                 600                 605

 gcc act cac agc tcc cgg cca ttc ctt ttg aca acc att gtg gca aga     1872
 Ala Thr His Ser Ser Arg Pro Phe Leu Leu Thr Thr Ile Val Ala Arg
     610                 615                 620

 gat gca gac tcg ggg gca aat gga gag ccc ctc tac agc atc cgc agt     1920
 Asp Ala Asp Ser Gly Ala Asn Gly Glu Pro Leu Tyr Ser Ile Arg Ser
 625                 630                 635                 640

 gga aat gaa gcc cac ctc ttc atc ctc aac cct cat acg ggg cag ctg     1968
 Gly Asn Glu Ala His Leu Phe Ile Leu Asn Pro His Thr Gly Gln Leu
                 645                 650                 655

 ttc gtc aat gtc acc aat gcc agc agc ctc att ggg agt gag tgg gag     2016
 Phe Val Asn Val Thr Asn Ala Ser Ser Leu Ile Gly Ser Glu Trp Glu
             660                 665                 670

 ctg gag ata gta gta gag gac cag gga agc ccc ccc tta cag acc cga     2064
 Leu Glu Ile Val Val Glu Asp Gln Gly Ser Pro Pro Leu Gln Thr Arg
         675                 680                 685

 gcc ctg ttg agg gtc atg ttt gtc acc agt gtg gac cac ctg agg gac     2112
 Ala Leu Leu Arg Val Met Phe Val Thr Ser Val Asp His Leu Arg Asp
     690                 695                 700

 tca gcc cgc aag cct ggg gcc ttg agc atg tcg atg ctg acg gtg atc     2160
 Ser Ala Arg Lys Pro Gly Ala Leu Ser Met Ser Met Leu Thr Val Ile
 705                 710                 715                 720

 tgc ctg gct gta ctg ttg ggc atc ttc ggg ttg atc ctg gct ttg ttc     2208
 Cys Leu Ala Val Leu Leu Gly Ile Phe Gly Leu Ile Leu Ala Leu Phe
                 725                 730                 735

 atg tcc atc tgc cgg aca gaa aag aag gac aac agg gcc tac aac tgt     2256
 Met Ser Ile Cys Arg Thr Glu Lys Lys Asp Asn Arg Ala Tyr Asn Cys
             740                 745                 750

 cgg gag gcc gag tcc acc tac cgc cag cag ccc aag agg ccc cag aaa     2304
 Arg Glu Ala Glu Ser Thr Tyr Arg Gln Gln Pro Lys Arg Pro Gln Lys
         755                 760                 765

 cac att cag aag gca gac atc cac ctc gtg cct gtg ctc agg ggt cag     2352
 His Ile Gln Lys Ala Asp Ile His Leu Val Pro Val Leu Arg Gly Gln
     770                 775                 780

 gca ggt gag cct tgt gaa gtc ggg cag tcc cac aaa gat gtg gac aag     2400
 Ala Gly Glu Pro Cys Glu Val Gly Gln Ser His Lys Asp Val Asp Lys
 785                 790                 795                 800

 gag gcg atg atg gaa gca ggc tgg gac ccc tgc ctg cag gcc ccc ttc     2448
 Glu Ala Met Met Glu Ala Gly Trp Asp Pro Cys Leu Gln Ala Pro Phe
                 805                 810                 815

 cac ctc acc ccg acc ctg tac agg acg ctg cgt aat caa ggc aac cag     2496
 His Leu Thr Pro Thr Leu Tyr Arg Thr Leu Arg Asn Gln Gly Asn Gln
             820                 825                 830

 gga gca ccg gcg gag agc cga gag gtg ctg caa gac acg gtc aac ctc     2544
 Gly Ala Pro Ala Glu Ser Arg Glu Val Leu Gln Asp Thr Val Asn Leu
         835                 840                 845

 ctt ttc aac cat ccc agg cag agg aat gcc tcc cgg gag aac ctg aac     2592
 Leu Phe Asn His Pro Arg Gln Arg Asn Ala Ser Arg Glu Asn Leu Asn
     850                 855                 860

 ctt ccc gag ccc cag cct gcc aca ggc cag cca cgt tcc agg cct ctg     2640
 Leu Pro Glu Pro Gln Pro Ala Thr Gly Gln Pro Arg Ser Arg Pro Leu
 865                 870                 875                 880

 aag gtt gca ggc agc ccc aca ggg agg ctg gct gga gac cag ggc agt     2688
 Lys Val Ala Gly Ser Pro Thr Gly Arg Leu Ala Gly Asp Gln Gly Ser
                 885                 890                 895

 gag gaa gcc cca cag agg cca cca gcc tcc tct gca acc ctg aga cgg     2736
 Glu Glu Ala Pro Gln Arg Pro Pro Ala Ser Ser Ala Thr Leu Arg Arg
             900                 905                 910

 cag cga cat ctc aat ggc aaa gtg tcc cct gag aaa gaa tca ggg ccc     2784
 Gln Arg His Leu Asn Gly Lys Val Ser Pro Glu Lys Glu Ser Gly Pro
         915                 920                 925

 cgt cag atc ctg cgg agc ctg gtc cgg ctg tct gtg gct gcc ttc gcc     2832
 Arg Gln Ile Leu Arg Ser Leu Val Arg Leu Ser Val Ala Ala Phe Ala
     930                 935                 940

 gag cgg aac ccc gtg gag gag ctc act gtg gat tct cct cct gtt cag     2880
 Glu Arg Asn Pro Val Glu Glu Leu Thr Val Asp Ser Pro Pro Val Gln
 945                 950                 955                 960

 caa atc tcc cag ctg ctg tcc ttg ctg cat cag ggc caa ttc cag ccc     2928
 Gln Ile Ser Gln Leu Leu Ser Leu Leu His Gln Gly Gln Phe Gln Pro
                 965                 970                 975

 aaa cca aac cac cga gga aat aag tac ttg gcc aag cca gga ggc agc     2976
 Lys Pro Asn His Arg Gly Asn Lys Tyr Leu Ala Lys Pro Gly Gly Ser
             980                 985                 990

 agg agt gca atc cca gac aca gat ggc cca agt gca agg gct gga ggc     3024
 Arg Ser Ala Ile Pro Asp Thr Asp Gly Pro Ser Ala Arg Ala Gly Gly
         995                1000                1005

 cag aca gac cca gaa cag gag gaa ggg cct ttg gat cct gaa gag gac     3072
 Gln Thr Asp Pro Glu Gln Glu Glu Gly Pro Leu Asp Pro Glu Glu Asp
    1010                1015                1020

 ctc tct gtg aag caa ctg cta gaa gaa gag ctg tca agt ctg ctg gac     3120
 Leu Ser Val Lys Gln Leu Leu Glu Glu Glu Leu Ser Ser Leu Leu Asp
1025                1030                1035                1040

 ccc agc aca gat ctg ctt cag att gct tca gat ttg ctg ctt cgg att     3168
 Pro Ser Thr Asp Leu Leu Gln Ile Ala Ser Asp Leu Leu Leu Arg Ile
                1045                1050                1055

 cag att gcc cca ctt gag aat gcg acc atg ata atg ttt tcc tgg ttg     3216
 Gln Ile Ala Pro Leu Glu Asn Ala Thr Met Ile Met Phe Ser Trp Leu
            1060                1065                1070

 cat gaa ctc act gaa cct cac aac aac tcc aca aga tac gta cta ctg     3264
 His Glu Leu Thr Glu Pro His Asn Asn Ser Thr Arg Tyr Val Leu Leu
        1075                1080                1085

 tct cac cac ttc cta aga gga aac ggg agc tta gag agg tta agc cat     3312
 Ser His His Phe Leu Arg Gly Asn Gly Ser Leu Glu Arg Leu Ser His
    1090                1095                1100

 ttt ccc aag gtc aca cac act gcc cct aag ctg caa agc tgg gaa atc     3360
 Phe Pro Lys Val Thr His Thr Ala Pro Lys Leu Gln Ser Trp Glu Ile
1105                1110                1115                1120

 aaa ccc agg ttg gcc cag tgc cca cct gca gct aga act ggt ctg gcc     3408
 Lys Pro Arg Leu Ala Gln Cys Pro Pro Ala Ala Arg Thr Gly Leu Ala
                1125                1130                1135

 ctg gac cgg ctg agc gcc cct gac ccg gcc tgg atg gcg aga ctc tct     3456
 Leu Asp Arg Leu Ser Ala Pro Asp Pro Ala Trp Met Ala Arg Leu Ser
            1140                1145                1150

 ttg ccc ctc acc acc aac tac cgt gac aat gtg atc tcc ccg gat gct     3504
 Leu Pro Leu Thr Thr Asn Tyr Arg Asp Asn Val Ile Ser Pro Asp Ala
        1155                1160                1165

 gca gcc acg gag gag cca agg acc ttc cag acg ttc ggc aag gca gag     3552
 Ala Ala Thr Glu Glu Pro Arg Thr Phe Gln Thr Phe Gly Lys Ala Glu
    1170                1175                1180

 gca cca gag ctg agc cca aca ggc acg agg ctg gcc agc acc ttt gtc     3600
 Ala Pro Glu Leu Ser Pro Thr Gly Thr Arg Leu Ala Ser Thr Phe Val
1185                1190                1195                1200

 tcg gag atg agc tca ctg ctg gag atg ctg ctg gaa cag cgc tcc agc     3648
 Ser Glu Met Ser Ser Leu Leu Glu Met Leu Leu Glu Gln Arg Ser Ser
                1205                1210                1215

 atg ccc gtg gag gcc gcc tcc gag gcg ctg cgg cgg ctc tcg gga tac     3696
 Met Pro Val Glu Ala Ala Ser Glu Ala Leu Arg Arg Leu Ser Gly Tyr
            1220                1225                1230

 aca cat cag aca ttg gca aac agt agt aca gat tta agt gtg aga aaa     3744
 Thr His Gln Thr Leu Ala Asn Ser Ser Thr Asp Leu Ser Val Arg Lys
        1235                1240                1245

 ccc agg cat aag aag gaa gaa gtc aaa ctt ctg gga aga gtt gtc tac     3792
 Pro Arg His Lys Lys Glu Glu Val Lys Leu Leu Gly Arg Val Val Tyr
    1250                1255                1260

 aca ttc tcc ccc tgc ttc tat aac aca cag gcc aaa agt ctc tcc aac     3840
 Thr Phe Ser Pro Cys Phe Tyr Asn Thr Gln Ala Lys Ser Leu Ser Asn
1265                1270                1275                1280

 aaa cat gac aga ctc atg cct aca gac cac gtt aca aca cag cag tgg     3888
 Lys His Asp Arg Leu Met Pro Thr Asp His Val Thr Thr Gln Gln Trp
                1285                1290                1295

 aca cac gct tca tcc cca aca tgc ttg tcc act gag atc gca tac ccc     3936
 Thr His Ala Ser Ser Pro Thr Cys Leu Ser Thr Glu Ile Ala Tyr Pro
            1300                1305                1310

 att gtt ggc tgc aag cca aag ata ttt cac agc tct ctg ctc atc cag     3984
 Ile Val Gly Cys Lys Pro Lys Ile Phe His Ser Ser Leu Leu Ile Gln
        1315                1320                1325

 gaa gtt gaa agc gat gga aac act gag ctg gaa gag ctg ctg aat gga     4032
 Glu Val Glu Ser Asp Gly Asn Thr Glu Leu Glu Glu Leu Leu Asn Gly
    1330                1335                1340

 agt cac agc ctc ctc aag gga aag agt ttt tga                         4065
 Ser His Ser Leu Leu Lys Gly Lys Ser Phe 
1345                1350





      <210> 861
      <211> 408
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (1)..(408)

      <220>
      <221> misc_feature
      <222> (1)...(408)
      <223> n = a,t,c or g

      <400> 861
  atg gag agc gct ctc ccc gcc gcc ggc ttc ctg tac tgg gtc ggc gcg      48
  Met Glu Ser Ala Leu Pro Ala Ala Gly Phe Leu Tyr Trp Val Gly Ala
    1               5                  10                  15

 ggc acc gtg gcc tac cta gcc ctg cgt att tcg tac tcg ctc ttc acg       96
 Gly Thr Val Ala Tyr Leu Ala Leu Arg Ile Ser Tyr Ser Leu Phe Thr
              20                  25                  30

 gcc ctc cgg gtc tgg gga gtg ggg aat gag gcn ggg ggt cgg ccc ggg      144
 Ala Leu Arg Val Trp Gly Val Gly Asn Glu XXX Gly Gly Arg Pro Gly
          35                  40                  45

 gct cgg aga atg ggc agg aga aca aaa gga gat cct gtg aat gtg gag      192
 Ala Arg Arg Met Gly Arg Arg Thr Lys Gly Asp Pro Val Asn Val Glu
      50                  55                  60

 ttt cag gtg ttt gaa gag acc att tct gtc tgg ggg aaa agt ctg atc      240
 Phe Gln Val Phe Glu Glu Thr Ile Ser Val Trp Gly Lys Ser Leu Ile
  65                  70                  75                  80

 act gtg gta tgg gaa gtt ctt ctc tta cag gga ctg agt gat ggg gtt      288
 Thr Val Val Trp Glu Val Leu Leu Leu Gln Gly Leu Ser Asp Gly Val
                  85                  90                  95

 att gaa aca ctg aaa cta ggt tat tgc gtt gtc atg cgt gtt ctg gac      336
 Ile Glu Thr Leu Lys Leu Gly Tyr Cys Val Val Met Arg Val Leu Asp
             100                 105                 110

 ttc ctt att ttt gct aat tat gtc atc gtc ttg cta gtc atg aag ctc      384
 Phe Leu Ile Phe Ala Asn Tyr Val Ile Val Leu Leu Val Met Lys Leu
         115                 120                 125

 caa atc aga gat ggc aaa ttc tga                                      408
 Gln Ile Arg Asp Gly Lys Phe 
     130                 135





      <210> 862
      <211> 888
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (325)..(888)

      <400> 862
 atggtgtgtc cggagtttct tccttcagat gttcagatgt gtctggagtt tcttccttct     60

 ggttggttca tgatcttgct gacttcagga gtgaagctgc agaccttcac agtaccaagc    120

 acgtacattg gcatgggctt tatgaatatt gaaatggtaa attataggaa taggcagaag    180

 cagatcatag ttttaactga agccgtttgg aaacccactt attctaaaaa tgtattcatt    240

 taattccatt tttctcttca catcgttgag ctttgctacc caacttcctc acttcacatt    300

 ggagaagagc ttcccgtggt tgtg   atg ggg cct tta atg ctg aat gca atc     351
                              Met Gly Pro Leu Met Leu Asn Ala Ile
                                1               5

 ctg ctt ctt ttg gtt ttg atc aga tgg ggc tgt cag cta ctc ttt gcc      399
 Leu Leu Leu Leu Val Leu Ile Arg Trp Gly Cys Gln Leu Leu Phe Ala
  10                  15                  20                  25

 tcc tgt cct gat gtc ttg tca aag tta atc att acc atg gga cta tgg      447
 Ser Cys Pro Asp Val Leu Ser Lys Leu Ile Ile Thr Met Gly Leu Trp
                  30                  35                  40

 aca att ctg gac cca ttg gca gtg ttt ata ctg gat act ctc ctg ggg      495
 Thr Ile Leu Asp Pro Leu Ala Val Phe Ile Leu Asp Thr Leu Leu Gly
              45                  50                  55

 cgg ctt aca gat aat gag gag act cct gtg gcg gat gcc gcg aag ctc      543
 Arg Leu Thr Asp Asn Glu Glu Thr Pro Val Ala Asp Ala Ala Lys Leu
          60                  65                  70

 tac tgg atg ttt gta aga acc gtg cag cca ggc att ctt ggc gtg gtg      591
 Tyr Trp Met Phe Val Arg Thr Val Gln Pro Gly Ile Leu Gly Val Val
      75                  80                  85

 atc aca gtg ctg ctt tac atc ctc ctg ttc gtc att tct tct ttg att      639
 Ile Thr Val Leu Leu Tyr Ile Leu Leu Phe Val Ile Ser Ser Leu Ile
  90                  95                 100                 105

 tta tat tta tat tgt ctt agc act att tac aat agc aaa gac atg gaa      687
 Leu Tyr Leu Tyr Cys Leu Ser Thr Ile Tyr Asn Ser Lys Asp Met Glu
                 110                 115                 120

 cca acc aaa tgc cca tca gtg ata gac tgg atg aag aaa gtg tgg tac      735
 Pro Thr Lys Cys Pro Ser Val Ile Asp Trp Met Lys Lys Val Trp Tyr
             125                 130                 135

 ata tgc acc atg gaa tac tct gca gcc ata aaa agg aat gag atc atg      783
 Ile Cys Thr Met Glu Tyr Ser Ala Ala Ile Lys Arg Asn Glu Ile Met
         140                 145                 150

 tcc ttt tca ggg aca tgg atg aag ctg gaa gcc atc atc ctc agc aaa      831
 Ser Phe Ser Gly Thr Trp Met Lys Leu Glu Ala Ile Ile Leu Ser Lys
     155                 160                 165

 cta aca cag gaa cag aaa acc aaa cac tgc atg ttc tca ctc ata agt      879
 Leu Thr Gln Glu Gln Lys Thr Lys His Cys Met Phe Ser Leu Ile Ser
 170                 175                 180                 185

 ggg agt tga                                                          888
 Gly Ser 






      <210> 863
      <211> 4278
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (1)..(4278)

      <400> 863
  atg act ggt ttg tca gcc tcc ctc ttg gga att tct tcc cca tgc cta      48
  Met Thr Gly Leu Ser Ala Ser Leu Leu Gly Ile Ser Ser Pro Cys Leu
    1               5                  10                  15

 ttc cgt agg tgc tgc agc ctg ccc tcc gtg cat tcc tgc agc cta ccc       96
 Phe Arg Arg Cys Cys Ser Leu Pro Ser Val His Ser Cys Ser Leu Pro
              20                  25                  30

 tcc gtg cgt tcc tgc agc ctg ccc tct gtg cgt tcc tgc agc ctg ccc      144
 Ser Val Arg Ser Cys Ser Leu Pro Ser Val Arg Ser Cys Ser Leu Pro
          35                  40                  45

 tct ctg tgt tcc tgc agc ctg ccc tct gtg cat tcc tgc agc ctg ccc      192
 Ser Leu Cys Ser Cys Ser Leu Pro Ser Val His Ser Cys Ser Leu Pro
      50                  55                  60

 tct ctg ttc ctg cag cct gcc ccc tct gtg ttc ctg cag cct gcc ctc      240
 Ser Leu Phe Leu Gln Pro Ala Pro Ser Val Phe Leu Gln Pro Ala Leu
  65                  70                  75                  80

 tct gtg ttc ctg cag cct gcc ctc tct gtg ttc ctg cag cct gcc ctc      288
 Ser Val Phe Leu Gln Pro Ala Leu Ser Val Phe Leu Gln Pro Ala Leu
                  85                  90                  95

 tct gtg ttc ctg cag cct gcc ctc tct gtg ttc ctg cag cct gcc ctc      336
 Ser Val Phe Leu Gln Pro Ala Leu Ser Val Phe Leu Gln Pro Ala Leu
             100                 105                 110

 cgt gcg ttc ctg cag cct gcc ctc cgt gcg ttc ctg cag cct gcc ctc      384
 Arg Ala Phe Leu Gln Pro Ala Leu Arg Ala Phe Leu Gln Pro Ala Leu
         115                 120                 125

 tgt gcg ttc ctg cag cct gcc ctc tct gtg ttc ctg cag cct gcc ctc      432
 Cys Ala Phe Leu Gln Pro Ala Leu Ser Val Phe Leu Gln Pro Ala Leu
     130                 135                 140

 tct gtg ttc ctg cag cct gcc ctc tct gtg ttc ctg cag cct gcc ctc      480
 Ser Val Phe Leu Gln Pro Ala Leu Ser Val Phe Leu Gln Pro Ala Leu
 145                 150                 155                 160

 tct gtg ttc ctg cag cct gcc ctc cgt gca ttc ctg cag cct gcc ctc      528
 Ser Val Phe Leu Gln Pro Ala Leu Arg Ala Phe Leu Gln Pro Ala Leu
                 165                 170                 175

 cct gtg ttc ctg cag cct gcc ctc tgt gcg ttc ctg cag cct gcc ctc      576
 Pro Val Phe Leu Gln Pro Ala Leu Cys Ala Phe Leu Gln Pro Ala Leu
             180                 185                 190

 cgt gcg ttc ctg cag cct gcc ctc tct gtg ttc ctg cag cct gcc ctc      624
 Arg Ala Phe Leu Gln Pro Ala Leu Ser Val Phe Leu Gln Pro Ala Leu
         195                 200                 205

 cgt gcg ttc ctg cag cct gcc ctc cct gtg ttc ctg cag cct gcc ctc      672
 Arg Ala Phe Leu Gln Pro Ala Leu Pro Val Phe Leu Gln Pro Ala Leu
     210                 215                 220

 cgt gcg ttt ctg cag cct gcc ctc tct gtg ttc ctg cag cct gcc ctc      720
 Arg Ala Phe Leu Gln Pro Ala Leu Ser Val Phe Leu Gln Pro Ala Leu
 225                 230                 235                 240

 tct gtg ttc ctg caa cct gcc ctc cgt gca ttc ctg cag cct gcc ctc      768
 Ser Val Phe Leu Gln Pro Ala Leu Arg Ala Phe Leu Gln Pro Ala Leu
                 245                 250                 255

 cgt gca ttc ctg cag cct gcc ctc tcc tgc cct gtg ttc ctg cag cct      816
 Arg Ala Phe Leu Gln Pro Ala Leu Ser Cys Pro Val Phe Leu Gln Pro
             260                 265                 270

 gcc ctc tct gtg ttc ctg cag cct gcc ctc tct gtg ttc ctg cag cct      864
 Ala Leu Ser Val Phe Leu Gln Pro Ala Leu Ser Val Phe Leu Gln Pro
         275                 280                 285

 gcc ctc cgt gcg ttc ctg cag cct gcc ctc tct gtg ttc ctg cag cct      912
 Ala Leu Arg Ala Phe Leu Gln Pro Ala Leu Ser Val Phe Leu Gln Pro
     290                 295                 300

 gcc ctc cct gtg ttc ctg cag cct gcc ctc cgt gcg ttc ctg cag cct      960
 Ala Leu Pro Val Phe Leu Gln Pro Ala Leu Arg Ala Phe Leu Gln Pro
 305                 310                 315                 320

 gcc ctc cct gtg ttc ctg cag cct gcc ctc cct gtg ttc ctg cag cct     1008
 Ala Leu Pro Val Phe Leu Gln Pro Ala Leu Pro Val Phe Leu Gln Pro
                 325                 330                 335

 gcc ctc tgt gcg ttc ctg cag ctt gcc ctc tcc tgc cct gtg ttc ctg     1056
 Ala Leu Cys Ala Phe Leu Gln Leu Ala Leu Ser Cys Pro Val Phe Leu
             340                 345                 350

 cag cct gcc ctc tct gtg ttc ctg cag cct gcc ctc cgt gcg ttc ctg     1104
 Gln Pro Ala Leu Ser Val Phe Leu Gln Pro Ala Leu Arg Ala Phe Leu
         355                 360                 365

 cag cct gcc ctc cct gtg ttc ctg cag cct gcc ctc cct gtg ttc ctg     1152
 Gln Pro Ala Leu Pro Val Phe Leu Gln Pro Ala Leu Pro Val Phe Leu
     370                 375                 380

 cag cct gcc ctc cgt gcg ttc ctg cag cct gcc ctc cct gtg ttc ctg     1200
 Gln Pro Ala Leu Arg Ala Phe Leu Gln Pro Ala Leu Pro Val Phe Leu
 385                 390                 395                 400

 cag cct gcc ctc cct gtg ttc ctg cag cct gcc ctc tcc ccg gct gtc     1248
 Gln Pro Ala Leu Pro Val Phe Leu Gln Pro Ala Leu Ser Pro Ala Val
                 405                 410                 415

 ccc agc tca cca gct ggc atc ttt ggg cat atc gct gtc att ggc tct     1296
 Pro Ser Ser Pro Ala Gly Ile Phe Gly His Ile Ala Val Ile Gly Ser
             420                 425                 430

 ccc ttc ccc acc gct gga ggg aac aca tca gat tct ttc tcc aat ggc     1344
 Pro Phe Pro Thr Ala Gly Gly Asn Thr Ser Asp Ser Phe Ser Asn Gly
         435                 440                 445

 tgt tct caa gat gtt ggc agc cca agg ctc tgt ggc tgt ggg ctg ctg     1392
 Cys Ser Gln Asp Val Gly Ser Pro Arg Leu Cys Gly Cys Gly Leu Leu
     450                 455                 460

 gga gtg ggc atc tgg ctc tcc gtg tcc caa ggc aac ttt gcc acc ttc     1440
 Gly Val Gly Ile Trp Leu Ser Val Ser Gln Gly Asn Phe Ala Thr Phe
 465                 470                 475                 480

 tcc ccc agc ttc cct tcg ttg tct gca gcc aac ctg gtc att gcc ata     1488
 Ser Pro Ser Phe Pro Ser Leu Ser Ala Ala Asn Leu Val Ile Ala Ile
                 485                 490                 495

 ggc acc att gtc atg gtg acg ggc ttc ctc ggc tgc ctg ggg gcc atc     1536
 Gly Thr Ile Val Met Val Thr Gly Phe Leu Gly Cys Leu Gly Ala Ile
             500                 505                 510

 aag gaa aac aag tgc ctc ctc ctc agc ttt ttc atc gtc ctg ttg gtc     1584
 Lys Glu Asn Lys Cys Leu Leu Leu Ser Phe Phe Ile Val Leu Leu Val
         515                 520                 525

 atc ctc cta gca gag ctg atc tta ctc atc ctc ttc ttt gtc tac atg     1632
 Ile Leu Leu Ala Glu Leu Ile Leu Leu Ile Leu Phe Phe Val Tyr Met
     530                 535                 540

 gac aag gtg aac gag aac gcc aag aag gac ctg aag gaa ggc ctg ctg     1680
 Asp Lys Val Asn Glu Asn Ala Lys Lys Asp Leu Lys Glu Gly Leu Leu
 545                 550                 555                 560

 ctg tac cac acc gag aac aac gtg ggg ctg aag aac gcc tgg aac atc     1728
 Leu Tyr His Thr Glu Asn Asn Val Gly Leu Lys Asn Ala Trp Asn Ile
                 565                 570                 575

 atc cag gct gag ggt ggc cac ttt tgc ggg gac tgg ggt tgg cct ggg     1776
 Ile Gln Ala Glu Gly Gly His Phe Cys Gly Asp Trp Gly Trp Pro Gly
             580                 585                 590

 cag ggg aag gcc ctg ggg agg aag ggg cgg gcc atg gca tgt ctg act     1824
 Gln Gly Lys Ala Leu Gly Arg Lys Gly Arg Ala Met Ala Cys Leu Thr
         595                 600                 605

 gcc cct tcc att cct gct ggc cag atg cga tgc tgt ggt gtc act gac     1872
 Ala Pro Ser Ile Pro Ala Gly Gln Met Arg Cys Cys Gly Val Thr Asp
     610                 615                 620

 tac aca gac tgg tac cca gtg ctg ggg gag aac acg gtt ccc gac cgc     1920
 Tyr Thr Asp Trp Tyr Pro Val Leu Gly Glu Asn Thr Val Pro Asp Arg
 625                 630                 635                 640

 tgc tgc atg gag aac tcc cag ggc tgc ggg cgc aac gcc acc acg cct     1968
 Cys Cys Met Glu Asn Ser Gln Gly Cys Gly Arg Asn Ala Thr Thr Pro
                 645                 650                 655

 ttg tgg aga acg ggc tgc tat gaa aag gtg aag atg tgg ttc gat gac     2016
 Leu Trp Arg Thr Gly Cys Tyr Glu Lys Val Lys Met Trp Phe Asp Asp
             660                 665                 670

 aat aag cac gtg ctg ggc acg gtg ggg atg tgc atc ctc atc atg cag     2064
 Asn Lys His Val Leu Gly Thr Val Gly Met Cys Ile Leu Ile Met Gln
         675                 680                 685

 atc ctg ggc atg gcc ttc tcc atg acc ctc ttc cag cac atc cac cgg     2112
 Ile Leu Gly Met Ala Phe Ser Met Thr Leu Phe Gln His Ile His Arg
     690                 695                 700

 act gac agt cag agg ctg ctg ctg tgg ccg ttg agt gaa cga ctg aac     2160
 Thr Asp Ser Gln Arg Leu Leu Leu Trp Pro Leu Ser Glu Arg Leu Asn
 705                 710                 715                 720

 att ggc caa gga ggt cct gaa gac aca gga gag cgg ggc agg gct ggg     2208
 Ile Gly Gln Gly Gly Pro Glu Asp Thr Gly Glu Arg Gly Arg Ala Gly
                 725                 730                 735

 gct ctc gtg cga agc ggg tcc ccg ctg gac ctc ggg tgg atc cac ctg     2256
 Ala Leu Val Arg Ser Gly Ser Pro Leu Asp Leu Gly Trp Ile His Leu
             740                 745                 750

 ttc aca cag cac gtg gcc agg ctg cgt cgg gtt cac acc aca cca ggc     2304
 Phe Thr Gln His Val Ala Arg Leu Arg Arg Val His Thr Thr Pro Gly
         755                 760                 765

 tgg ttg cgc atc ctg gta aac ggt gtg aag ata ttg act gac cag aga     2352
 Trp Leu Arg Ile Leu Val Asn Gly Val Lys Ile Leu Thr Asp Gln Arg
     770                 775                 780

 cag aaa gct tta caa gga aca caa ttc aag tac aca tgt ttg agc ctg     2400
 Gln Lys Ala Leu Gln Gly Thr Gln Phe Lys Tyr Thr Cys Leu Ser Leu
 785                 790                 795                 800

 gct ctc gct gac agc cag gag cta atg aca ctt gtg agc aga aga agt     2448
 Ala Leu Ala Asp Ser Gln Glu Leu Met Thr Leu Val Ser Arg Arg Ser
                 805                 810                 815

 caa ttc aaa caa atc atg acc aga gct gac aga agg gct cag agt ggc     2496
 Gln Phe Lys Gln Ile Met Thr Arg Ala Asp Arg Arg Ala Gln Ser Gly
             820                 825                 830

 cag tac acg gag cat gtt ttc aag gca ggt cct agg gtg ggt ggt ggt     2544
 Gln Tyr Thr Glu His Val Phe Lys Ala Gly Pro Arg Val Gly Gly Gly
         835                 840                 845

 gat ggt gac tgt tcc acc tca ctg ccc ctg cct gaa atc ctt gaa gag     2592
 Asp Gly Asp Cys Ser Thr Ser Leu Pro Leu Pro Glu Ile Leu Glu Glu
     850                 855                 860

 ggg ccc gga gtg gca gac tct gag acc aaa gct ggc aac agg gct gga     2640
 Gly Pro Gly Val Ala Asp Ser Glu Thr Lys Ala Gly Asn Arg Ala Gly
 865                 870                 875                 880

 ggg tcc cgg gca cat cat act gac ata cca tgg ccc ccc tgc ccc cag     2688
 Gly Ser Arg Ala His His Thr Asp Ile Pro Trp Pro Pro Cys Pro Gln
                 885                 890                 895

 ggc cac att ggg ccc ttc tgg ctg tca ggg cct ttg gcc gtg cac aag     2736
 Gly His Ile Gly Pro Phe Trp Leu Ser Gly Pro Leu Ala Val His Lys
             900                 905                 910

 gct gct ggc ctg gac atg gag gtc gta ttt cca aga agc tct ggg ctg     2784
 Ala Ala Gly Leu Asp Met Glu Val Val Phe Pro Arg Ser Ser Gly Leu
         915                 920                 925

 tcc tac cac ttt ctg cag ctt gga cca gcc aat ctc ccc aac gga aat     2832
 Ser Tyr His Phe Leu Gln Leu Gly Pro Ala Asn Leu Pro Asn Gly Asn
     930                 935                 940

 ctg ggc tgg aca acc gcc agt gca gga atc aca gct aat cct gcc tcc     2880
 Leu Gly Trp Thr Thr Ala Ser Ala Gly Ile Thr Ala Asn Pro Ala Ser
 945                 950                 955                 960

 aac tcc gga aca aaa ctc agg tcc gtt atg gat gct ctg cca tgt gca     2928
 Asn Ser Gly Thr Lys Leu Arg Ser Val Met Asp Ala Leu Pro Cys Ala
                 965                 970                 975

 aga gcc atg ggg gaa acg gag act ctg gga gga gcc cct aga gct gtc     2976
 Arg Ala Met Gly Glu Thr Glu Thr Leu Gly Gly Ala Pro Arg Ala Val
             980                 985                 990

 atc agc tct gac act gag cct ggt gca gtg gca cag agc agc cct gcc     3024
 Ile Ser Ser Asp Thr Glu Pro Gly Ala Val Ala Gln Ser Ser Pro Ala
         995                1000                1005

 cca gtt ccc agt ggt gac tcc tct ggg gtt cag cac atg gga cag aag     3072
 Pro Val Pro Ser Gly Asp Ser Ser Gly Val Gln His Met Gly Gln Lys
    1010                1015                1020

 acc tgc cct ggg gag gtg caa aag agc ggc aat gct aac gcc acc tgg     3120
 Thr Cys Pro Gly Glu Val Gln Lys Ser Gly Asn Ala Asn Ala Thr Trp
1025                1030                1035                1040

 gct ccc tgg ccc tgc aga cct ctg agt cgg ggt agg gag ttt gcg aaa     3168
 Ala Pro Trp Pro Cys Arg Pro Leu Ser Arg Gly Arg Glu Phe Ala Lys
                1045                1050                1055

 gcg aag ggc caa tat cag gag atc ggg gcg cca ttt cag ggg acg gtg     3216
 Ala Lys Gly Gln Tyr Gln Glu Ile Gly Ala Pro Phe Gln Gly Thr Val
            1060                1065                1070

 ctc ata gca ctg gac ggg gaa ggg ctg gct tgc gct ggg gca ctt acc     3264
 Leu Ile Ala Leu Asp Gly Glu Gly Leu Ala Cys Ala Gly Ala Leu Thr
        1075                1080                1085

 acc ccc ttg cag atg ttg gag ggg tgg gcc ggc tgg ctg cag agc gcc     3312
 Thr Pro Leu Gln Met Leu Glu Gly Trp Ala Gly Trp Leu Gln Ser Ala
    1090                1095                1100

 acc act gcc ttg cag ccg ctg tcg ggc act ggt ggc tct cac ctc cca     3360
 Thr Thr Ala Leu Gln Pro Leu Ser Gly Thr Gly Gly Ser His Leu Pro
1105                1110                1115                1120

 cga cag cag cag agc agg aaa gct gag aat gtg ctg gaa atg ctt gtt     3408
 Arg Gln Gln Gln Ser Arg Lys Ala Glu Asn Val Leu Glu Met Leu Val
                1125                1130                1135

 gag gcc gac gtg tca ggc agc cca tca gtg cag gat gga gcc tcg gtt     3456
 Glu Ala Asp Val Ser Gly Ser Pro Ser Val Gln Asp Gly Ala Ser Val
            1140                1145                1150

 gca gag aac tgc agg gag gtg gtg tgg aag ctc att ggc tgt aag aac     3504
 Ala Glu Asn Cys Arg Glu Val Val Trp Lys Leu Ile Gly Cys Lys Asn
        1155                1160                1165

 tgc tcc gct gcg aca gtg ctg ctg gag gtg gtg gtg aac agg gac tac     3552
 Cys Ser Ala Ala Thr Val Leu Leu Glu Val Val Val Asn Arg Asp Tyr
    1170                1175                1180

 tgg cct tta agg gct cct cag aac caa ggg tct ggg tca gaa gaa agg     3600
 Trp Pro Leu Arg Ala Pro Gln Asn Gln Gly Ser Gly Ser Glu Glu Arg
1185                1190                1195                1200

 ttc cag gtg agg gct tct gcc ttc cct ctt gtg ctg tcc aga gag cat     3648
 Phe Gln Val Arg Ala Ser Ala Phe Pro Leu Val Leu Ser Arg Glu His
                1205                1210                1215

 gga gag gca gcc ctt ctg ctc cta gga gat ggt gct gtt gcc cag gaa     3696
 Gly Glu Ala Ala Leu Leu Leu Leu Gly Asp Gly Ala Val Ala Gln Glu
            1220                1225                1230

 gcc ggt cac cat gac gag agt acc cgc tca gat gag gat gca ggc gga     3744
 Ala Gly His His Asp Glu Ser Thr Arg Ser Asp Glu Asp Ala Gly Gly
        1235                1240                1245

 ggc ggt gaa ggt gct gga ggc cag gat gct gag atc ctg aca gcc aag     3792
 Gly Gly Glu Gly Ala Gly Gly Gln Asp Ala Glu Ile Leu Thr Ala Lys
    1250                1255                1260

 agg ggt aga ggt gcc ccg aaa gcc gtg ggg agt ccc atg cca ttc agc     3840
 Arg Gly Arg Gly Ala Pro Lys Ala Val Gly Ser Pro Met Pro Phe Ser
1265                1270                1275                1280

 atc tca aga agc ggt gca gca gag aaa cca gct acg agg tcc ctc acc     3888
 Ile Ser Arg Ser Gly Ala Ala Glu Lys Pro Ala Thr Arg Ser Leu Thr
                1285                1290                1295

 tgt ttt tcc tca aat ggc aag ccc agg aag ggg gca gag gcc acg ttc     3936
 Cys Phe Ser Ser Asn Gly Lys Pro Arg Lys Gly Ala Glu Ala Thr Phe
            1300                1305                1310

 agt ggg gtg atg ctg tcc gag gtg aag ggc ttt cta gct ctg gca aag     3984
 Ser Gly Val Met Leu Ser Glu Val Lys Gly Phe Leu Ala Leu Ala Lys
        1315                1320                1325

 aga cgc acc cag gaa aaa tac ttc aca tcc ttc aat cca atc aag ttg     4032
 Arg Arg Thr Gln Glu Lys Tyr Phe Thr Ser Phe Asn Pro Ile Lys Leu
    1330                1335                1340

 aca ctc agt gtt aac cat cac agc atc ata tac cgt aag gat aat ggc     4080
 Thr Leu Ser Val Asn His His Ser Ile Ile Tyr Arg Lys Asp Asn Gly
1345                1350                1355                1360

 ccc aag cgg aca ggc tat ggt cct cag gaa gac atc acc cag gca ggt     4128
 Pro Lys Arg Thr Gly Tyr Gly Pro Gln Glu Asp Ile Thr Gln Ala Gly
                1365                1370                1375

 ttc ctg cgg gga gtc acc ata gag acc att tcc atc aca ggc agc agc     4176
 Phe Leu Arg Gly Val Thr Ile Glu Thr Ile Ser Ile Thr Gly Ser Ser
            1380                1385                1390

 agc ctg agc ttc cgg gac ttc tgt ttc cct gcc ctg ggc ctg gag aat     4224
 Ser Leu Ser Phe Arg Asp Phe Cys Phe Pro Ala Leu Gly Leu Glu Asn
        1395                1400                1405

 gtt aac cat gaa agg caa atg ggc ttc ggg tat acc cag act gga gtg     4272
 Val Asn His Glu Arg Gln Met Gly Phe Gly Tyr Thr Gln Thr Gly Val
    1410                1415                1420

 cag tag                                                             4278
 Gln 
1425





      <210> 864
      <211> 1026
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (22)..(1026)

      <400> 864
 atcttggcag aaaacctcac c  atg gtc acc gaa ttc ctg ttg ctg ggt ttt      51
                          Met Val Thr Glu Phe Leu Leu Leu Gly Phe
                            1               5                  10

 tcc agc ctt ggt gaa att cag ctg gcc ctc ttt gta gtt ttt ctt ttt       99
 Ser Ser Leu Gly Glu Ile Gln Leu Ala Leu Phe Val Val Phe Leu Phe
                  15                  20                  25

 ctg tat cta gtc att ctt agt ggc aat gtc acc att atc agt gtc atc      147
 Leu Tyr Leu Val Ile Leu Ser Gly Asn Val Thr Ile Ile Ser Val Ile
              30                  35                  40

 cac ctg gat aaa agc ctc cac aca cca atg tac ttc ttc ctt ggc att      195
 His Leu Asp Lys Ser Leu His Thr Pro Met Tyr Phe Phe Leu Gly Ile
          45                  50                  55

 ctc tca aca tct gag acc ttc tac acc ttt gtc att cta ccc aag atg      243
 Leu Ser Thr Ser Glu Thr Phe Tyr Thr Phe Val Ile Leu Pro Lys Met
      60                  65                  70

 ctc atc aat cta ctt tct gtg gcc agg aca atc tcc ttc aac tgt tgt      291
 Leu Ile Asn Leu Leu Ser Val Ala Arg Thr Ile Ser Phe Asn Cys Cys
  75                  80                  85                  90

 gct ctt caa atg ttc ttc ttc ctt ggt ttt gcc att acc aac tgc ctg      339
 Ala Leu Gln Met Phe Phe Phe Leu Gly Phe Ala Ile Thr Asn Cys Leu
                  95                 100                 105

 cta ttg ggt gtg atg ggt tat gat cgc tat gct gcc att tgt cac cct      387
 Leu Leu Gly Val Met Gly Tyr Asp Arg Tyr Ala Ala Ile Cys His Pro
             110                 115                 120

 ctg cat tac ccc act ctt atg agc tgg cag gcc agt aac tgc aga ttt      435
 Leu His Tyr Pro Thr Leu Met Ser Trp Gln Ala Ser Asn Cys Arg Phe
         125                 130                 135

 cta cat tca gat ttc tca ggt att ctt tct atc tct gaa atc ttc tac      483
 Leu His Ser Asp Phe Ser Gly Ile Leu Ser Ile Ser Glu Ile Phe Tyr
     140                 145                 150

 aca act gtt att ctg ccc aag atg ctt atc aac tta ttc tct gta ttc      531
 Thr Thr Val Ile Leu Pro Lys Met Leu Ile Asn Leu Phe Ser Val Phe
 155                 160                 165                 170

 agg aca ctc tcc ttt gtg agt tgt gcc acc caa atg ttc ttc ttc ctc      579
 Arg Thr Leu Ser Phe Val Ser Cys Ala Thr Gln Met Phe Phe Phe Leu
                 175                 180                 185

 ggt ttt gct gtc act aac tgt ctg ctt ctg gga gtg atg ggt tat gat      627
 Gly Phe Ala Val Thr Asn Cys Leu Leu Leu Gly Val Met Gly Tyr Asp
             190                 195                 200

 cgt tat gct gcc atc tgt cag cct ttg caa tac gct gtt ctc atg agc      675
 Arg Tyr Ala Ala Ile Cys Gln Pro Leu Gln Tyr Ala Val Leu Met Ser
         205                 210                 215

 tgg aga gta tgt gga caa ctg ata gca act tgt att att agt ggc ttc      723
 Trp Arg Val Cys Gly Gln Leu Ile Ala Thr Cys Ile Ile Ser Gly Phe
     220                 225                 230

 cta ata tct ctg gtg gga aca act ttt gtc ttt agc ctc cct ttc tgt      771
 Leu Ile Ser Leu Val Gly Thr Thr Phe Val Phe Ser Leu Pro Phe Cys
 235                 240                 245                 250

 ggc tcc aac aag gtc aac cac tac ttt tgt gat att tca cca gtt atc      819
 Gly Ser Asn Lys Val Asn His Tyr Phe Cys Asp Ile Ser Pro Val Ile
                 255                 260                 265

 cgt ctc gcc tgt gct gac agc tac atc agt gaa ctg gtc atc ttc atc      867
 Arg Leu Ala Cys Ala Asp Ser Tyr Ile Ser Glu Leu Val Ile Phe Ile
             270                 275                 280

 ttc ggg gtc ttg gtg ctt gtt gtg ccc ttg ata ttt atc tgc att tcc      915
 Phe Gly Val Leu Val Leu Val Val Pro Leu Ile Phe Ile Cys Ile Ser
         285                 290                 295

 tat ggc ttc att gtc cgc acc atc ctg aag atc cca tca gct gaa ggc      963
 Tyr Gly Phe Ile Val Arg Thr Ile Leu Lys Ile Pro Ser Ala Glu Gly
     300                 305                 310

 aaa caa aaa gcc ttc tcc acc tgt gct tcc cat ctc att gta gtc att     1011
 Lys Gln Lys Ala Phe Ser Thr Cys Ala Ser His Leu Ile Val Val Ile
 315                 320                 325                 330

 gtc cat tat ggt tga                                                 1026
 Val His Tyr Gly 






      <210> 865
      <211> 543
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (359)..(543)

      <400> 865
 atggtcttag caaatggcac accaggagat tatatcccgc acctggctgg ctgggagggt     60

 cccacgccca cagagcctcg ctcactgcta gcacagcagt ctaagatcga actgcaagac    120

 gacatgattg tatatttaga aagccccatt gtctcagccc aaaatctcct taagctgata    180

 agcaactgca gcaaagtctc aggatacaaa attgatatgc aaaaatcaca agcattccta    240

 tacaccaata acagacaaac agagagccaa atcatgagga catggatgaa gctggaaacc    300

 atcattctca gcaaactatc gcaagggcag aagaccaaac accgcatgtt ctcactca      358                                                                 
 tag caa ggc tgc tgt gtg ctg aga ccg tcg ctg ggg ctg aca gcc gct      406
 Met Ser Glu Asn Met Arg Cys Leu Val Phe Cys Pro Cys Asp Ser Leu
   1               5                  10                  15

 tta tgt gtt ctc ttc aca taa gcc agc ttg agc ttc ttg aaa aca tga      454
 Leu Arg Met Met Val Ser Ser Phe Ile His Val Leu Met Ile Trp Leu
              20                  25                  30

 tgg ata gct ttc caa gtt tca gtc ctt tca ctg atg tgc aga agg tca      502
 Ser Val Cys Leu Leu Leu Val Tyr Arg Asn Ala Cys Asp Phe Cys Ile
          35                  40                  45

 ctg tat cca aga tag agc ctc ctg aaa cac agt aca ggt ag               543
 Ser Ile Leu Tyr Pro Glu Thr Leu Leu Gln Leu Leu Ile Ser Leu Arg 
      50                  55                  60





      <210> 866
      <211> 552
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (1)..(552)

      <400> 866
  atg gct cgc ctc cag ctc cct cca cag ggt tgg cag gga gcc ctg gga      48
  Met Ala Arg Leu Gln Leu Pro Pro Gln Gly Trp Gln Gly Ala Leu Gly
    1               5                  10                  15

 cag gta gct gcc tgg tgg act cca gga acg gcc ctg ggg att tgc cat       96
 Gln Val Ala Ala Trp Trp Thr Pro Gly Thr Ala Leu Gly Ile Cys His
              20                  25                  30

 gtg act aaa gct tgc gtt gcc ctg cac tac aac aca act gct cag ctg      144
 Val Thr Lys Ala Cys Val Ala Leu His Tyr Asn Thr Thr Ala Gln Leu
          35                  40                  45

 tcc aga caa ctg gtc aca ctc ttc tct gtg cct ccc cag gaa cca ggg      192
 Ser Arg Gln Leu Val Thr Leu Phe Ser Val Pro Pro Gln Glu Pro Gly
      50                  55                  60

 aga gaa agt ggg cct ggt cat tcc cgc ctc cga gag ccc aga gcc gag      240
 Arg Glu Ser Gly Pro Gly His Ser Arg Leu Arg Glu Pro Arg Ala Glu
  65                  70                  75                  80

 atg gaa acg gtc cag gag ctg atc ccc ctg gcc aag gag atg atg gcc      288
 Met Glu Thr Val Gln Glu Leu Ile Pro Leu Ala Lys Glu Met Met Ala
                  85                  90                  95

 cag aag cgc aag ggg aag atg gtg aag ctg tac gtg ctg ggc agc gtg      336
 Gln Lys Arg Lys Gly Lys Met Val Lys Leu Tyr Val Leu Gly Ser Val
             100                 105                 110

 ctg gcc ctc ttc ggc gtg gtg ctc ggc ctg atg gag act gtg tgc agc      384
 Leu Ala Leu Phe Gly Val Val Leu Gly Leu Met Glu Thr Val Cys Ser
         115                 120                 125

 ccc ttc acg gcc gcc aga cgt ctg cgg gac cag gag gca gcc gtg gcg      432
 Pro Phe Thr Ala Ala Arg Arg Leu Arg Asp Gln Glu Ala Ala Val Ala
     130                 135                 140

 gag ctg cag gcc gcc ctg gag cga cag gct ctc cag aag caa gcc ctg      480
 Glu Leu Gln Ala Ala Leu Glu Arg Gln Ala Leu Gln Lys Gln Ala Leu
 145                 150                 155                 160

 cag gag aaa ggc aag cag cag gac acg gtc ctc ggc ggc cgg gcc ctg      528
 Gln Glu Lys Gly Lys Gln Gln Asp Thr Val Leu Gly Gly Arg Ala Leu
                 165                 170                 175

 tcc aac cgg cag cac gcc tcc tag                                      552
 Ser Asn Arg Gln His Ala Ser 
             180





      <210> 867
      <211> 753
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (1)..(753)

      <400> 867
  atg tct gag cac ttc aag acg aca tcg cag aag gtg gct cga aaa ttc      48
  Met Ser Glu His Phe Lys Thr Thr Ser Gln Lys Val Ala Arg Lys Phe
    1               5                  10                  15

 tgg tgg aag aac gtg aag atg att gtc ctt atc tgc gtg att gtt ttt       96
 Trp Trp Lys Asn Val Lys Met Ile Val Leu Ile Cys Val Ile Val Phe
              20                  25                  30

 atc atc atc ctc ttc att gtg ctc ttt gcc act gag aat gct gct cgg      144
 Ile Ile Ile Leu Phe Ile Val Leu Phe Ala Thr Glu Asn Ala Ala Arg
          35                  40                  45

 tcc tcc tac ccc tct tcc cga ggc cct gct gcc atg ttg tat gcc cca      192
 Ser Ser Tyr Pro Ser Ser Arg Gly Pro Ala Ala Met Leu Tyr Ala Pro
      50                  55                  60

 gaa ggt ctc aag aac aag aat ttt ctg gga gtc ttg gca tat gga aag      240
 Glu Gly Leu Lys Asn Lys Asn Phe Leu Gly Val Leu Ala Tyr Gly Lys
  65                  70                  75                  80

 ttc aaa acc ttc ata gca ttt tgg ggt ggc cag tgg gaa acc tta ggg      288
 Phe Lys Thr Phe Ile Ala Phe Trp Gly Gly Gln Trp Glu Thr Leu Gly
                  85                  90                  95

 cag ctg tgc att gat tgg gta gac gcc att ctg gag cag gca gga ata      336
 Gln Leu Cys Ile Asp Trp Val Asp Ala Ile Leu Glu Gln Ala Gly Ile
             100                 105                 110

 gag ttg gag cgg tgc cag cag cag gcg aac gag gtg acg gaa att atg      384
 Glu Leu Glu Arg Cys Gln Gln Gln Ala Asn Glu Val Thr Glu Ile Met
         115                 120                 125

 cgt aac aac ttc ggc aag gtc ctg gag cgt ggt gtg aag ctg gcc gaa      432
 Arg Asn Asn Phe Gly Lys Val Leu Glu Arg Gly Val Lys Leu Ala Glu
     130                 135                 140

 ctg cag cag cgt tca gac caa ctc ctg gat atg agc tca acc ttc aac      480
 Leu Gln Gln Arg Ser Asp Gln Leu Leu Asp Met Ser Ser Thr Phe Asn
 145                 150                 155                 160

 aag act aca cag aac ctg gcc cag aag aag tgc tgg gag aac atc cgt      528
 Lys Thr Thr Gln Asn Leu Ala Gln Lys Lys Cys Trp Glu Asn Ile Arg
                 165                 170                 175

 tac cgg atc tgc gtg ggg ctg gtg gtg gtt ggt gtc ctg ctc atc atc      576
 Tyr Arg Ile Cys Val Gly Leu Val Val Val Gly Val Leu Leu Ile Ile
             180                 185                 190

 ctg att gtg ctg ctg gtc gtc ttt ctc cct cag agc agg ctg ctt aaa      624
 Leu Ile Val Leu Leu Val Val Phe Leu Pro Gln Ser Arg Leu Leu Lys
         195                 200                 205

 aag ccc atc acc caa agg act cca ccc ctg gga gat ggc tcc ttc ctc      672
 Lys Pro Ile Thr Gln Arg Thr Pro Pro Leu Gly Asp Gly Ser Phe Leu
     210                 215                 220

 tcc ctt ccc tac ttg atc cag ccc gac aca gac agg gag tgt gga tgc      720
 Ser Leu Pro Tyr Leu Ile Gln Pro Asp Thr Asp Arg Glu Cys Gly Cys
 225                 230                 235                 240

 aag aac aca atg gcc ccc aaa gca gac cct tga                          753
 Lys Asn Thr Met Ala Pro Lys Ala Asp Pro 
                 245                 250





      <210> 868
      <211> 1248
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (1)..(1248)

      <400> 868
  atg ctg gct gct ccg tcc tgt ggc ctg ctg ggt ttc act ctt cca cgg      48
  Met Leu Ala Ala Pro Ser Cys Gly Leu Leu Gly Phe Thr Leu Pro Arg
    1               5                  10                  15

 cgt ggc ctc tcc cta gaa gcc ctt ggt gaa cac ccc tct ccc tgt gag       96
 Arg Gly Leu Ser Leu Glu Ala Leu Gly Glu His Pro Ser Pro Cys Glu
              20                  25                  30

 tct ggg gca gtc cct gcc gcc ccc agc cag tgg ctc ccg cag ctt ccc      144
 Ser Gly Ala Val Pro Ala Ala Pro Ser Gln Trp Leu Pro Gln Leu Pro
          35                  40                  45

 ggt gct ggc tca gtc ctg gca atg acc aca ctg cag gct cat ctg tct      192
 Gly Ala Gly Ser Val Leu Ala Met Thr Thr Leu Gln Ala His Leu Ser
      50                  55                  60

 cca ctc ctt ccc cgg aag ctc att gat gac gtg gtt ctc cag ccg act      240
 Pro Leu Leu Pro Arg Lys Leu Ile Asp Asp Val Val Leu Gln Pro Thr
  65                  70                  75                  80

 gct gcc cag gtg tgc tcg gcc cct tca tct gtc agc tgc agc aat gga      288
 Ala Ala Gln Val Cys Ser Ala Pro Ser Ser Val Ser Cys Ser Asn Gly
                  85                  90                  95

 ata cgt gct gga agt gaa gaa ctc tcc gcg gca cct cct gaa gca att      336
 Ile Arg Ala Gly Ser Glu Glu Leu Ser Ala Ala Pro Pro Glu Ala Ile
             100                 105                 110

 cac agg tat gga ggg aag gcg cca ggg ggg cgg ggc tgt aag cag tgc      384
 His Arg Tyr Gly Gly Lys Ala Pro Gly Gly Arg Gly Cys Lys Gln Cys
         115                 120                 125

 agc tgt tgt gtg tac aag ctg ctg ctg ctg ggc ctg gcc acc ccg tct      432
 Ser Cys Cys Val Tyr Lys Leu Leu Leu Leu Gly Leu Ala Thr Pro Ser
     130                 135                 140

 gtg agg ggc tgt cag ggg ctg ctg gag gct ggt gcc act tct cag ggt      480
 Val Arg Gly Cys Gln Gly Leu Leu Glu Ala Gly Ala Thr Ser Gln Gly
 145                 150                 155                 160

 gca tgg gac tgg tgg ggg tca tct cag gtg cgg cat cgc ctc ggc agg      528
 Ala Trp Asp Trp Trp Gly Ser Ser Gln Val Arg His Arg Leu Gly Arg
                 165                 170                 175

 gct ccc gtg tcc atg atg ctt ctg aca gag gat gag ggc tgc agc cgc      576
 Ala Pro Val Ser Met Met Leu Leu Thr Glu Asp Glu Gly Cys Ser Arg
             180                 185                 190

 agc att tgc aaa cct gga atg ggg ccc agt ccc tcg gtg gcc cat ggc      624
 Ser Ile Cys Lys Pro Gly Met Gly Pro Ser Pro Ser Val Ala His Gly
         195                 200                 205

 cga tca agg cag cca cat ccc tcg ggg ctg aac atg ttg tgt gac gtt      672
 Arg Ser Arg Gln Pro His Pro Ser Gly Leu Asn Met Leu Cys Asp Val
     210                 215                 220

 cct ctg tat gac att tgt gac tac aac gtc tcc agg gac cga tgc cag      720
 Pro Leu Tyr Asp Ile Cys Asp Tyr Asn Val Ser Arg Asp Arg Cys Gln
 225                 230                 235                 240

 gag ctc ggg tgc tgc ttc tac gaa ggc gtc tgc tac aag aaa gcg gtt      768
 Glu Leu Gly Cys Cys Phe Tyr Glu Gly Val Cys Tyr Lys Lys Ala Val
                 245                 250                 255

 ccc agt aag caa gtt tcc acg gga cag tcc tca ctt aaa gaa ata agg      816
 Pro Ser Lys Gln Val Ser Thr Gly Gln Ser Ser Leu Lys Glu Ile Arg
             260                 265                 270

 cag ctg att gga aga atg ttt gac aag cag ttt ccc agt gtg ctc ctc      864
 Gln Leu Ile Gly Arg Met Phe Asp Lys Gln Phe Pro Ser Val Leu Leu
         275                 280                 285

 gtt tac atc cac gtg ttc tct gcc ttg att gtg atc atc gct ggg gcc      912
 Val Tyr Ile His Val Phe Ser Ala Leu Ile Val Ile Ile Ala Gly Ala
     290                 295                 300

 ttc gtc atc acc atc atc tac aga gtc att cag gag agc agg aaa gaa      960
 Phe Val Ile Thr Ile Ile Tyr Arg Val Ile Gln Glu Ser Arg Lys Glu
 305                 310                 315                 320

 aag gcc atc cct gtg gat gtc gcg ctg cca cag aag tcc agc gaa aag     1008
 Lys Ala Ile Pro Val Asp Val Ala Leu Pro Gln Lys Ser Ser Glu Lys
                 325                 330                 335

 gcg gag ttg gcc tca tcc agc agc aag tta ggg ctg aag cct gcg agt     1056
 Ala Glu Leu Ala Ser Ser Ser Ser Lys Leu Gly Leu Lys Pro Ala Ser
             340                 345                 350

 cct ggg cct cca agt gct ggg ccc tcg atg aag agt gac gag gat aag     1104
 Pro Gly Pro Pro Ser Ala Gly Pro Ser Met Lys Ser Asp Glu Asp Lys
         355                 360                 365

 gat gat ggt ccc tcc gct gct tgg ctc tgc ggc tgt agc gtg aag gca     1152
 Asp Asp Gly Pro Ser Ala Ala Trp Leu Cys Gly Cys Ser Val Lys Ala
     370                 375                 380

 gac acc gac gat gcc tcc agg aag gac gtg gcc ttg ctc caa aaa gac     1200
 Asp Thr Asp Asp Ala Ser Arg Lys Asp Val Ala Leu Leu Gln Lys Asp
 385                 390                 395                 400

 ttt ctt atg gaa gcc agt gac ggg ctg gac gct gcc tac aag ctg tag     1248
 Phe Leu Met Glu Ala Ser Asp Gly Leu Asp Ala Ala Tyr Lys Leu 
                 405                 410                 415





      <210> 869
      <211> 1053
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (1)..(1053)

      <400> 869
  atg ggg gtc atg gct ccc cga acc ctc ctc ctg ctg ctc ttg ggg gcc      48
  Met Gly Val Met Ala Pro Arg Thr Leu Leu Leu Leu Leu Leu Gly Ala
    1               5                  10                  15

 ctg gcc ctg acc gag acc tgg gcc ggc tcc cac tcc ttg agg tat ttc       96
 Leu Ala Leu Thr Glu Thr Trp Ala Gly Ser His Ser Leu Arg Tyr Phe
              20                  25                  30

 agc acc gca gtg tcc cag ccc ggc cgc ggg gag ccc cgg ttc atc gcc      144
 Ser Thr Ala Val Ser Gln Pro Gly Arg Gly Glu Pro Arg Phe Ile Ala
          35                  40                  45

 gtg ggc tac gtg gac gac aca gag ttc gtg cgg ttc gac agc gac tcc      192
 Val Gly Tyr Val Asp Asp Thr Glu Phe Val Arg Phe Asp Ser Asp Ser
      50                  55                  60

 gtg agt ccg agg atg gag cgg cgg gcg ccg tgg gtg gag cag gag ggg      240
 Val Ser Pro Arg Met Glu Arg Arg Ala Pro Trp Val Glu Gln Glu Gly
  65                  70                  75                  80

 ctg gag tat tgg gac cag gag aca cgg aac gcc aag ggc cac gcg cag      288
 Leu Glu Tyr Trp Asp Gln Glu Thr Arg Asn Ala Lys Gly His Ala Gln
                  85                  90                  95

 att tac cga gtg aac ctg cgg acc ctg ctc cgc tat tac aac cag agc      336
 Ile Tyr Arg Val Asn Leu Arg Thr Leu Leu Arg Tyr Tyr Asn Gln Ser
             100                 105                 110

 gag gcc gag gaa gca tgg ctg cga cgt ggg ccc gac agg cgc ctc ctc      384
 Glu Ala Glu Glu Ala Trp Leu Arg Arg Gly Pro Asp Arg Arg Leu Leu
         115                 120                 125

 cgc agg tat gaa cag ttc gcc tac gat ggc aag gat tac atc gcc ctg      432
 Arg Arg Tyr Glu Gln Phe Ala Tyr Asp Gly Lys Asp Tyr Ile Ala Leu
     130                 135                 140

 aac gag gac ctg cac tcc tgg acc gcc gcg aac aca gcg gct cag atc      480
 Asn Glu Asp Leu His Ser Trp Thr Ala Ala Asn Thr Ala Ala Gln Ile
 145                 150                 155                 160

 tcc cag cac aag tgg gaa gcg gac aaa tac tca gag cag gtc agg gcc      528
 Ser Gln His Lys Trp Glu Ala Asp Lys Tyr Ser Glu Gln Val Arg Ala
                 165                 170                 175

 tac ctg agg gca aat ccc cca aag gca cat gtg acc cag cac ccc atc      576
 Tyr Leu Arg Ala Asn Pro Pro Lys Ala His Val Thr Gln His Pro Ile
             180                 185                 190

 tct gac cat gag gcc acc ctg agg tgc tgg gcc ctg ggc ctc tac cct      624
 Ser Asp His Glu Ala Thr Leu Arg Cys Trp Ala Leu Gly Leu Tyr Pro
         195                 200                 205

 gcg gag atc aca ctg acc tgg cag cag gat ggg gag gac cag acc cag      672
 Ala Glu Ile Thr Leu Thr Trp Gln Gln Asp Gly Glu Asp Gln Thr Gln
     210                 215                 220

 gac acg gag ctt gtg gag acc agg cct gca ggg gac gga acc ttc cag      720
 Asp Thr Glu Leu Val Glu Thr Arg Pro Ala Gly Asp Gly Thr Phe Gln
 225                 230                 235                 240

 aag tgg gtg gct gta gtg gtg cct tcc gga gag gag cag aga tac atg      768
 Lys Trp Val Ala Val Val Val Pro Ser Gly Glu Glu Gln Arg Tyr Met
                 245                 250                 255

 tgc cat gtg cag cat gag ggg ctg cca gag ccc ctc acc ctg aga tgg      816
 Cys His Val Gln His Glu Gly Leu Pro Glu Pro Leu Thr Leu Arg Trp
             260                 265                 270

 gag ccg tct tct cag ccc acc atc ccc atc gtg ggc atc gtt gct ggc      864
 Glu Pro Ser Ser Gln Pro Thr Ile Pro Ile Val Gly Ile Val Ala Gly
         275                 280                 285

 ctg ttt ctc ctt gga gct gtg gtc act gga gct gtg gtt gct gct gcg      912
 Leu Phe Leu Leu Gly Ala Val Val Thr Gly Ala Val Val Ala Ala Ala
     290                 295                 300

 atg tgg agg aag aaa agc tca ggt agg gaa ggg gaa cca ctg tcc ctg      960
 Met Trp Arg Lys Lys Ser Ser Gly Arg Glu Gly Glu Pro Leu Ser Leu
 305                 310                 315                 320

 ctc ctg agc aca gat gct act gca tat acc tct gat acc ctg atg gcc     1008
 Leu Leu Ser Thr Asp Ala Thr Ala Tyr Thr Ser Asp Thr Leu Met Ala
                 325                 330                 335

 gac act ggg ccc tgt ggc aaa gac tgc tat cac tgc tgc tcc tga         1053
 Asp Thr Gly Pro Cys Gly Lys Asp Cys Tyr His Cys Cys Ser 
             340                 345                 350





      <210> 870
      <211> 1188
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (1)..(1188)

      <400> 870
  atg gct cat tcc aag cag cct agt cac ttc cag agt ctg atg ctt ctg      48
  Met Ala His Ser Lys Gln Pro Ser His Phe Gln Ser Leu Met Leu Leu
    1               5                  10                  15

 cag tgg cct ttg agc tac ctt gcc atc ttt tgg atc ttg cag cca ttg       96
 Gln Trp Pro Leu Ser Tyr Leu Ala Ile Phe Trp Ile Leu Gln Pro Leu
              20                  25                  30

 ttc gtc tac ctg ctg ttt aca tcc ttg tgg ccg cta cca gtg ctt tac      144
 Phe Val Tyr Leu Leu Phe Thr Ser Leu Trp Pro Leu Pro Val Leu Tyr
          35                  40                  45

 ttt gcc tgg ttg ttc ctg gac tgg aag acc cca gag cga ggt ggc agg      192
 Phe Ala Trp Leu Phe Leu Asp Trp Lys Thr Pro Glu Arg Gly Gly Arg
      50                  55                  60

 cgt tcg gcc tgg gta agg aac tgg tgt gtc tgg acc cac atc agg gac      240
 Arg Ser Ala Trp Val Arg Asn Trp Cys Val Trp Thr His Ile Arg Asp
  65                  70                  75                  80

 tat ttc ccc att acg atc ctg aag aca aag gac cta tca cct gag cac      288
 Tyr Phe Pro Ile Thr Ile Leu Lys Thr Lys Asp Leu Ser Pro Glu His
                  85                  90                  95

 aac tac ctc atg ggg gtt cac ccc cat ggc ctc ctg acc ttt ggc gcc      336
 Asn Tyr Leu Met Gly Val His Pro His Gly Leu Leu Thr Phe Gly Ala
             100                 105                 110

 ttc tgc aac ttc tgc act gag gcc aca ggc ttc tcg aag acc ttc cca      384
 Phe Cys Asn Phe Cys Thr Glu Ala Thr Gly Phe Ser Lys Thr Phe Pro
         115                 120                 125

 ggc atc act cct cac ttg gcc acg ctg tcc tgg ttc ttc aag atc ccc      432
 Gly Ile Thr Pro His Leu Ala Thr Leu Ser Trp Phe Phe Lys Ile Pro
     130                 135                 140

 ttt gtt agg gag tac ctc atg gcc aaa ggt gtg tgc tct gtg agc cag      480
 Phe Val Arg Glu Tyr Leu Met Ala Lys Gly Val Cys Ser Val Ser Gln
 145                 150                 155                 160

 cca gcc atc aac tat ctg ctg agc cat ggc act ggc aac ctc gtg ggc      528
 Pro Ala Ile Asn Tyr Leu Leu Ser His Gly Thr Gly Asn Leu Val Gly
                 165                 170                 175

 att gta gtg gga ggt gtg ggt gag gcc ctg caa agt gtg ccc aac acc      576
 Ile Val Val Gly Gly Val Gly Glu Ala Leu Gln Ser Val Pro Asn Thr
             180                 185                 190

 acc acc ctc atc ctc cag aag cgc aag ggg ttc gtg cgc aca gcc ctc      624
 Thr Thr Leu Ile Leu Gln Lys Arg Lys Gly Phe Val Arg Thr Ala Leu
         195                 200                 205

 cag cat ggg ttc aat atc aag ggg att ggg cta agg ctg ccc tgg cat      672
 Gln His Gly Phe Asn Ile Lys Gly Ile Gly Leu Arg Leu Pro Trp His
     210                 215                 220

 ata gat gat gcc cac att atc tct atc aat gct ggt atc tac atc tgt      720
 Ile Asp Asp Ala His Ile Ile Ser Ile Asn Ala Gly Ile Tyr Ile Cys
 225                 230                 235                 240

 ctg cta atg gat ttc atc aaa ata gat gag ggc ctg gca agc aaa caa      768
 Leu Leu Met Asp Phe Ile Lys Ile Asp Glu Gly Leu Ala Ser Lys Gln
                 245                 250                 255

 atg ttc ttc cag ggt ggg tct cat cct agc ttg tgt tta gaa aat aaa      816
 Met Phe Phe Gln Gly Gly Ser His Pro Ser Leu Cys Leu Glu Asn Lys
             260                 265                 270

 ttg gag ttt tcc tac agg gct cat ctg gtc ccc acc ttc act ttt ggg      864
 Leu Glu Phe Ser Tyr Arg Ala His Leu Val Pro Thr Phe Thr Phe Gly
         275                 280                 285

 gaa act gag gtg tat gat cag gtg ctg ttc cat aag gat agc agg atg      912
 Glu Thr Glu Val Tyr Asp Gln Val Leu Phe His Lys Asp Ser Arg Met
     290                 295                 300

 tac aag ttc cag agc tgc ttc cgc cgt atc ttt ggt ttc tac tgt tgt      960
 Tyr Lys Phe Gln Ser Cys Phe Arg Arg Ile Phe Gly Phe Tyr Cys Cys
 305                 310                 315                 320

 gtc ttc tat gga caa agc ttc tgt caa ggc tcc act ggg ctc ctg cca     1008
 Val Phe Tyr Gly Gln Ser Phe Cys Gln Gly Ser Thr Gly Leu Leu Pro
                 325                 330                 335

 tac tcc agg cct att gtc act gtg gtt ggg gag cct ctg cca ctg ccc     1056
 Tyr Ser Arg Pro Ile Val Thr Val Val Gly Glu Pro Leu Pro Leu Pro
             340                 345                 350

 caa att gaa aag cca agc cag gag atg gtg gac aaa tac cat gca ctt     1104
 Gln Ile Glu Lys Pro Ser Gln Glu Met Val Asp Lys Tyr His Ala Leu
         355                 360                 365

 tat atg gat gct ctg cac aaa ctg ttc gac cag cat aag acc cac tat     1152
 Tyr Met Asp Ala Leu His Lys Leu Phe Asp Gln His Lys Thr His Tyr
     370                 375                 380

 ggc tgc tca gag acc caa aag ctg ttt ttc ctg tga                     1188
 Gly Cys Ser Glu Thr Gln Lys Leu Phe Phe Leu 
 385                 390                 395





      <210> 871
      <211> 2469
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (1)..(2469)

      <400> 871
  atg gcg gtc gcg ggg ccc gcg ccc gga gct ggc gcc agg ccc agg tta      48
  Met Ala Val Ala Gly Pro Ala Pro Gly Ala Gly Ala Arg Pro Arg Leu
    1               5                  10                  15

 gat ctg caa ttt ctc cag cgg ttc ctg cag ata ctg aag gtt ttg ttt       96
 Asp Leu Gln Phe Leu Gln Arg Phe Leu Gln Ile Leu Lys Val Leu Phe
              20                  25                  30

 cct tct tgg tca tca caa aat gcc ttg atg ttc ctg acc ctt ttg tgc      144
 Pro Ser Trp Ser Ser Gln Asn Ala Leu Met Phe Leu Thr Leu Leu Cys
          35                  40                  45

 ctg acc cta ctg gag caa ttt gtg atc tac cag gtt ggc ttg atc ccc      192
 Leu Thr Leu Leu Glu Gln Phe Val Ile Tyr Gln Val Gly Leu Ile Pro
      50                  55                  60

 agt cag tac tat ggg gtc ctg gga aac aaa gac ttg gaa ggg ttt aag      240
 Ser Gln Tyr Tyr Gly Val Leu Gly Asn Lys Asp Leu Glu Gly Phe Lys
  65                  70                  75                  80

 act ctg aca ttc ctg gct gtc atg ctc att gtt ctg aac tcc acg ctg      288
 Thr Leu Thr Phe Leu Ala Val Met Leu Ile Val Leu Asn Ser Thr Leu
                  85                  90                  95

 aag agc ttt gat cag ttc acc tgc aac ctg ctg tat gtg agc tgg agg      336
 Lys Ser Phe Asp Gln Phe Thr Cys Asn Leu Leu Tyr Val Ser Trp Arg
             100                 105                 110

 aag gac ctc act gag cac ctt cac cgc ctc tac ttc cgg ggc cgt gcg      384
 Lys Asp Leu Thr Glu His Leu His Arg Leu Tyr Phe Arg Gly Arg Ala
         115                 120                 125

 tac tac acc ctc aac gtg ctg cgg gat gac atc gat aac ccg gac cag      432
 Tyr Tyr Thr Leu Asn Val Leu Arg Asp Asp Ile Asp Asn Pro Asp Gln
     130                 135                 140

 cgc atc agc cag gac gtg gag cga ttc tgc cgg cag ctc agc agc atg      480
 Arg Ile Ser Gln Asp Val Glu Arg Phe Cys Arg Gln Leu Ser Ser Met
 145                 150                 155                 160

 gcc agc aag ctc atc atc tcc ccg ttc acc ctc gtc tac tac act tac      528
 Ala Ser Lys Leu Ile Ile Ser Pro Phe Thr Leu Val Tyr Tyr Thr Tyr
                 165                 170                 175

 cag tgc ttc caa agc aca ggc tgg ctc ggg cct gtg agc atc ttc ggg      576
 Gln Cys Phe Gln Ser Thr Gly Trp Leu Gly Pro Val Ser Ile Phe Gly
             180                 185                 190

 tat ttc atc ctg ggg acc gtg gtg aac aaa act ttg atg ggc ccc att      624
 Tyr Phe Ile Leu Gly Thr Val Val Asn Lys Thr Leu Met Gly Pro Ile
         195                 200                 205

 gtg atg aag ctg gtg cat cag gag aag ctg gag gga gat ttt agg ttc      672
 Val Met Lys Leu Val His Gln Glu Lys Leu Glu Gly Asp Phe Arg Phe
     210                 215                 220

 aag cac atg cag att cgg gtg aat gcg gag cct gct gct ttc tac agc      720
 Lys His Met Gln Ile Arg Val Asn Ala Glu Pro Ala Ala Phe Tyr Ser
 225                 230                 235                 240

 gtg gga tgg aat ggg agc ttc tca gaa aac cag gag acc tgc tcc cca      768
 Val Gly Trp Asn Gly Ser Phe Ser Glu Asn Gln Glu Thr Cys Ser Pro
                 245                 250                 255

 caa tgc tgt cta atg gag cca agc gtc tgg tct cct gac ggc agc agc      816
 Gln Cys Cys Leu Met Glu Pro Ser Val Trp Ser Pro Asp Gly Ser Ser
             260                 265                 270

 agg agc agc agc agc ggc atg aaa tcc cat ccc ttc cct cca ggg cca      864
 Arg Ser Ser Ser Ser Gly Met Lys Ser His Pro Phe Pro Pro Gly Pro
         275                 280                 285

 gaa ccg ggc atg tgg atg gtt cct ggg tgt ctc aca gat gtg ttt tct      912
 Glu Pro Gly Met Trp Met Val Pro Gly Cys Leu Thr Asp Val Phe Ser
     290                 295                 300

 aca gtc ggc atc aac acc ttt gac tat ctg ggc agc atc ctg agt tac      960
 Thr Val Gly Ile Asn Thr Phe Asp Tyr Leu Gly Ser Ile Leu Ser Tyr
 305                 310                 315                 320

 gtt gtc atc gca atc ccc att ttc agc ggg gtc tat gga gac ctg agt     1008
 Val Val Ile Ala Ile Pro Ile Phe Ser Gly Val Tyr Gly Asp Leu Ser
                 325                 330                 335

 ccc gca gag ctt agc acc ctg gtc agc aag aat gcc ttt gtg tgc atc     1056
 Pro Ala Glu Leu Ser Thr Leu Val Ser Lys Asn Ala Phe Val Cys Ile
             340                 345                 350

 tac ctc atc agc tgc ttc acc cag ctc atc gac ctg tcc acg acg ctc     1104
 Tyr Leu Ile Ser Cys Phe Thr Gln Leu Ile Asp Leu Ser Thr Thr Leu
         355                 360                 365

 tca gat gtg gct ggc tac acg cac aga att ggg cag ctt cgg gag acg     1152
 Ser Asp Val Ala Gly Tyr Thr His Arg Ile Gly Gln Leu Arg Glu Thr
     370                 375                 380

 ctt ctg gac atg tcc ctg aag tca cag gac tgc gag atc ctg ggc gag     1200
 Leu Leu Asp Met Ser Leu Lys Ser Gln Asp Cys Glu Ile Leu Gly Glu
 385                 390                 395                 400

 agc gag tgg ggc ttg gac aca ccc cca ggg tgg cca gcg gca gag cca     1248
 Ser Glu Trp Gly Leu Asp Thr Pro Pro Gly Trp Pro Ala Ala Glu Pro
                 405                 410                 415

 gca gac aca gca ttt ctc ctt gag cgg gtc tcc atc tct gcc ccc tcc     1296
 Ala Asp Thr Ala Phe Leu Leu Glu Arg Val Ser Ile Ser Ala Pro Ser
             420                 425                 430

 tct gac aaa ccc cta atc aag gat ctg agc cta aag atc tcc gag gga     1344
 Ser Asp Lys Pro Leu Ile Lys Asp Leu Ser Leu Lys Ile Ser Glu Gly
         435                 440                 445

 cag agc ctg ctc atc aca ggc aac acg ggc act ggc aag acc tcc ttg     1392
 Gln Ser Leu Leu Ile Thr Gly Asn Thr Gly Thr Gly Lys Thr Ser Leu
     450                 455                 460

 ctc cgg gtt ctg ggt ggc ctc tgg acg agt aca cgg ggc tca gtg cag     1440
 Leu Arg Val Leu Gly Gly Leu Trp Thr Ser Thr Arg Gly Ser Val Gln
 465                 470                 475                 480

 atg ctg acg gac ttt ggg ccc cat ggg gtg cta ttc ctg cca caa aag     1488
 Met Leu Thr Asp Phe Gly Pro His Gly Val Leu Phe Leu Pro Gln Lys
                 485                 490                 495

 cca ttc ttc act gac ggg acc ctt cgg gag cag gtg ata tat ccc ctg     1536
 Pro Phe Phe Thr Asp Gly Thr Leu Arg Glu Gln Val Ile Tyr Pro Leu
             500                 505                 510

 aag gag gtc tac ccc gac tca ggt tct gcc gat gat gag agg atc ttg     1584
 Lys Glu Val Tyr Pro Asp Ser Gly Ser Ala Asp Asp Glu Arg Ile Leu
         515                 520                 525

 agg ttc ttg gaa ttg gca ggc ctg tcc aac ttg gtg gca agg aca gag     1632
 Arg Phe Leu Glu Leu Ala Gly Leu Ser Asn Leu Val Ala Arg Thr Glu
     530                 535                 540

 ggc ctg gac cag cag gtg gac tgg aac tgg tat gat gtt ctg tcc ccg     1680
 Gly Leu Asp Gln Gln Val Asp Trp Asn Trp Tyr Asp Val Leu Ser Pro
 545                 550                 555                 560

 ggg gag atg caa cgg ctc tcc ttt gcc cga ctc ttc tac ctg cag ccg     1728
 Gly Glu Met Gln Arg Leu Ser Phe Ala Arg Leu Phe Tyr Leu Gln Pro
                 565                 570                 575

 aag tac gca gtg ctt gat gaa gcc acc agt gcc ctg aca gag gaa gtg     1776
 Lys Tyr Ala Val Leu Asp Glu Ala Thr Ser Ala Leu Thr Glu Glu Val
             580                 585                 590

 gag agc gag ctc tat cgc atc ggc cag cag ctg ggg atg acg ttc atc     1824
 Glu Ser Glu Leu Tyr Arg Ile Gly Gln Gln Leu Gly Met Thr Phe Ile
         595                 600                 605

 agt gtg gga cat cgg cag agc ctt gag aag gtg tca gaa ctg tct agc     1872
 Ser Val Gly His Arg Gln Ser Leu Glu Lys Val Ser Glu Leu Ser Ser
     610                 615                 620

 tct gga gct gga tct agg gct ggt gct aga gca gga gca ggc tct agc     1920
 Ser Gly Ala Gly Ser Arg Ala Gly Ala Arg Ala Gly Ala Gly Ser Ser
 625                 630                 635                 640

 ttc aaa gct gcc att gga gct gac tct agc tct aga gct gac acc aaa     1968
 Phe Lys Ala Ala Ile Gly Ala Asp Ser Ser Ser Arg Ala Asp Thr Lys
                 645                 650                 655

 gct gaa tat agc tct gtg gct ggc act aca act ggc tta agc tct gga     2016
 Ala Glu Tyr Ser Ser Val Ala Gly Thr Thr Thr Gly Leu Ser Ser Gly
             660                 665                 670

 aca ggt gat gga gct agt tct aga gct agc act ggc ttt agc tct gga     2064
 Thr Gly Asp Gly Ala Ser Ser Arg Ala Ser Thr Gly Phe Ser Ser Gly
         675                 680                 685

 ggt ggt gcc aaa gct ggc act tca cct ggc cta ggc tct gga gct ggt     2112
 Gly Gly Ala Lys Ala Gly Thr Ser Pro Gly Leu Gly Ser Gly Ala Gly
     690                 695                 700

 gct aga gct ggc tct agc ttc tca tct ggt gct gga gct agt gat gga     2160
 Ala Arg Ala Gly Ser Ser Phe Ser Ser Gly Ala Gly Ala Ser Asp Gly
 705                 710                 715                 720

 gct ggc tct agc tgt gct gct ggt gct gga gct ggc act agc tct gga     2208
 Ala Gly Ser Ser Cys Ala Ala Gly Ala Gly Ala Gly Thr Ser Ser Gly
                 725                 730                 735

 cct aga act tcc ttt agt gcc agc gtt ggt gct gaa cct gct tct ggc     2256
 Pro Arg Thr Ser Phe Ser Ala Ser Val Gly Ala Glu Pro Ala Ser Gly
             740                 745                 750

 tct gga gct ggc act aaa tct ggc tat agc tca cga gtg gat gcc aga     2304
 Ser Gly Ala Gly Thr Lys Ser Gly Tyr Ser Ser Arg Val Asp Ala Arg
         755                 760                 765

 gtt ggt gct gga gta ggt gca gag ctg tct gta gct cta gag ctg gag     2352
 Val Gly Ala Gly Val Gly Ala Glu Leu Ser Val Ala Leu Glu Leu Glu
     770                 775                 780

 cta gtg ctg ctt gtg ctg aag ctg atg gta gag ctg aca ccg gat ctg     2400
 Leu Val Leu Leu Val Leu Lys Leu Met Val Glu Leu Thr Pro Asp Leu
 785                 790                 795                 800

 gcc cta gct ctg gac ctg gtg tca gaa ctg gca ctg gag ctg gaa gag     2448
 Ala Leu Ala Leu Asp Leu Val Ser Glu Leu Ala Leu Glu Leu Glu Glu
                 805                 810                 815

 gag aaa ggt ttg cca gca tga                                         2469
 Glu Lys Gly Leu Pro Ala 
             820





      <210> 872
      <211> 2412
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (1)..(2412)

      <400> 872
  atg gtt gcc atg ggg atg ccc cag ttg ctc cag agg tgg ctt ctg gtc      48
  Met Val Ala Met Gly Met Pro Gln Leu Leu Gln Arg Trp Leu Leu Val
    1               5                  10                  15

 ccg gaa gcg ggg atg gca gag aca gcc aat cat cgc acc gag gcg ggt       96
 Pro Glu Ala Gly Met Ala Glu Thr Ala Asn His Arg Thr Glu Ala Gly
              20                  25                  30

 ggg ggt gaa aga ggg cac cag ggc cac aat gtg tct ggg gag att gct      144
 Gly Gly Glu Arg Gly His Gln Gly His Asn Val Ser Gly Glu Ile Ala
          35                  40                  45

 gga aga aaa tat gct gaa aag gcc agg att cct ggg gag ttt cag ggt      192
 Gly Arg Lys Tyr Ala Glu Lys Ala Arg Ile Pro Gly Glu Phe Gln Gly
      50                  55                  60

 gat tac aga cag gct ctt gag atc tgt ggc ctg aaa ggc gct gga agc      240
 Asp Tyr Arg Gln Ala Leu Glu Ile Cys Gly Leu Lys Gly Ala Gly Ser
  65                  70                  75                  80

 aga gcc tgt gag tgt ggt ccc cgt cac cag agc ccc aac cca ccg ccg      288
 Arg Ala Cys Glu Cys Gly Pro Arg His Gln Ser Pro Asn Pro Pro Pro
                  85                  90                  95

 cca tgg ttt ggg tgt gag gac act ggc cct cca agt ctc ttc agt gtc      336
 Pro Trp Phe Gly Cys Glu Asp Thr Gly Pro Pro Ser Leu Phe Ser Val
             100                 105                 110

 ggc aga cac cct gtg tta tcc ttg gag ctt ctg ctg gat gct aca gcc      384
 Gly Arg His Pro Val Leu Ser Leu Glu Leu Leu Leu Asp Ala Thr Ala
         115                 120                 125

 agt gcc cca tgg gtg acg ctt ctc cct gtt cag aga tcc ttc ttc ctg      432
 Ser Ala Pro Trp Val Thr Leu Leu Pro Val Gln Arg Ser Phe Phe Leu
     130                 135                 140

 cca ccc ttt tct gga gcc act ccc tct act tcc cta gca gag tct gtc      480
 Pro Pro Phe Ser Gly Ala Thr Pro Ser Thr Ser Leu Ala Glu Ser Val
 145                 150                 155                 160

 ctc aaa gtc tgg cat ggg gcc tac aac tct ggt ctc ctt ccc caa ctc      528
 Leu Lys Val Trp His Gly Ala Tyr Asn Ser Gly Leu Leu Pro Gln Leu
                 165                 170                 175

 atg gcc cag cac tcc cta gcc atg gcc cag aat ggt gct gtg ccc agc      576
 Met Ala Gln His Ser Leu Ala Met Ala Gln Asn Gly Ala Val Pro Ser
             180                 185                 190

 gag gcc acc aag agg gac cag aac ctc aaa cgg ggc aac tgg ggc aac      624
 Glu Ala Thr Lys Arg Asp Gln Asn Leu Lys Arg Gly Asn Trp Gly Asn
         195                 200                 205

 cag atc gag ttt gta ctg acg agc gtg ggc tat gcc gtg ggc ctg ggc      672
 Gln Ile Glu Phe Val Leu Thr Ser Val Gly Tyr Ala Val Gly Leu Gly
     210                 215                 220

 aat gtc tgg cgc ttc cca tac ctc tgc tat cgc aac ggg gga ggc gcc      720
 Asn Val Trp Arg Phe Pro Tyr Leu Cys Tyr Arg Asn Gly Gly Gly Ala
 225                 230                 235                 240

 ttc atg ttc ccc tac ttc atc atg ctc atc ttc tgc ggg atc ccc ctc      768
 Phe Met Phe Pro Tyr Phe Ile Met Leu Ile Phe Cys Gly Ile Pro Leu
                 245                 250                 255

 ttc ttc atg gag ctc tcc ttc ggc cag ttt gca agc cag ggg tgc ctg      816
 Phe Phe Met Glu Leu Ser Phe Gly Gln Phe Ala Ser Gln Gly Cys Leu
             260                 265                 270

 ggg gtc tgg agg atc agc ccc atg ttc aaa gga gtg ggc tat ggt atg      864
 Gly Val Trp Arg Ile Ser Pro Met Phe Lys Gly Val Gly Tyr Gly Met
         275                 280                 285

 atg gtg gtg tcc acc tac atc ggc atc tac tac aat gtg gtc atc tgc      912
 Met Val Val Ser Thr Tyr Ile Gly Ile Tyr Tyr Asn Val Val Ile Cys
     290                 295                 300

 atc gcc ttc tac tac ttc ttc tcg tcc atg acg cac gtg ctg ccc tgg      960
 Ile Ala Phe Tyr Tyr Phe Phe Ser Ser Met Thr His Val Leu Pro Trp
 305                 310                 315                 320

 gcc tac tgc aat aac ccc tgg aac acg cat gac tgc gcc ggt gta ctg     1008
 Ala Tyr Cys Asn Asn Pro Trp Asn Thr His Asp Cys Ala Gly Val Leu
                 325                 330                 335

 gac gcc tcc aac ctc acc aat ggc tct cgg cca gcc gcc ttg ccc agc     1056
 Asp Ala Ser Asn Leu Thr Asn Gly Ser Arg Pro Ala Ala Leu Pro Ser
             340                 345                 350

 aac ctc tcc cac ctg ctc aac cac agc ctc cag agg acc agc ccc agc     1104
 Asn Leu Ser His Leu Leu Asn His Ser Leu Gln Arg Thr Ser Pro Ser
         355                 360                 365

 gag gag tac tgg agg ctg tac gtg ctg aag ctg tca gat gac att ggg     1152
 Glu Glu Tyr Trp Arg Leu Tyr Val Leu Lys Leu Ser Asp Asp Ile Gly
     370                 375                 380

 aac ttt ggg gag gtg cgg ctg ccc ctc ctt ggc tgc ctc ggt gtc tcc     1200
 Asn Phe Gly Glu Val Arg Leu Pro Leu Leu Gly Cys Leu Gly Val Ser
 385                 390                 395                 400

 tgg ttg gtc gtc ttc ctc tgc ctc atc cga ggg gtg gtg tac ttc acg     1248
 Trp Leu Val Val Phe Leu Cys Leu Ile Arg Gly Val Val Tyr Phe Thr
                 405                 410                 415

 gcc acg ttc ccc tac gtg gtg ctg acc att ctg ttt gtc cgc gga gtg     1296
 Ala Thr Phe Pro Tyr Val Val Leu Thr Ile Leu Phe Val Arg Gly Val
             420                 425                 430

 acc ctg gag gga gcc ttt gac ggc atc atg tac tac cta acc ccg cag     1344
 Thr Leu Glu Gly Ala Phe Asp Gly Ile Met Tyr Tyr Leu Thr Pro Gln
         435                 440                 445

 tgg gac aag atc ctg gag gcc aag gtg tgg ggt gat gct gcc tcc cag     1392
 Trp Asp Lys Ile Leu Glu Ala Lys Val Trp Gly Asp Ala Ala Ser Gln
     450                 455                 460

 atc ttc tac tca ctg ggc tgc gcg tgg gga ggc ctc atc acc atg gct     1440
 Ile Phe Tyr Ser Leu Gly Cys Ala Trp Gly Gly Leu Ile Thr Met Ala
 465                 470                 475                 480

 tcc tac aac aag ttc cac aat aac tgt tac cgg gac agt gtc atc atc     1488
 Ser Tyr Asn Lys Phe His Asn Asn Cys Tyr Arg Asp Ser Val Ile Ile
                 485                 490                 495

 agc atc acc aac tgt gcc acc agc gtc tat gct ggc ttc gtc atc ttc     1536
 Ser Ile Thr Asn Cys Ala Thr Ser Val Tyr Ala Gly Phe Val Ile Phe
             500                 505                 510

 tcc atc ctc ggc ttc atg gcc aat cac ctg ggc gtg gat gtg tcc cgt     1584
 Ser Ile Leu Gly Phe Met Ala Asn His Leu Gly Val Asp Val Ser Arg
         515                 520                 525

 gtg gca gac cac ggc cct ggc ctg gcc ttc gtg gct tac ccc gag gcc     1632
 Val Ala Asp His Gly Pro Gly Leu Ala Phe Val Ala Tyr Pro Glu Ala
     530                 535                 540

 ctc aca cta ctt ccc atc tcc ccg ctg tgg tct ctg ctc ttc ttc ttc     1680
 Leu Thr Leu Leu Pro Ile Ser Pro Leu Trp Ser Leu Leu Phe Phe Phe
 545                 550                 555                 560

 atg ctt atc ctg ctg ggg ctg ggc act cag ttc tgc ctc ctg gag acg     1728
 Met Leu Ile Leu Leu Gly Leu Gly Thr Gln Phe Cys Leu Leu Glu Thr
                 565                 570                 575

 ctg gtc aca gcc att gtg gat gag gtg ggg aat gag tgg atc ctg cag     1776
 Leu Val Thr Ala Ile Val Asp Glu Val Gly Asn Glu Trp Ile Leu Gln
             580                 585                 590

 aaa aag acc tat gtg acc ttg ggc gtg gct gtg gct ggc ttc ctg ctg     1824
 Lys Lys Thr Tyr Val Thr Leu Gly Val Ala Val Ala Gly Phe Leu Leu
         595                 600                 605

 ggc atc ccc ctc acc agc cag gca ggc atc tat tgg ctg ctg ctg atg     1872
 Gly Ile Pro Leu Thr Ser Gln Ala Gly Ile Tyr Trp Leu Leu Leu Met
     610                 615                 620

 gac aac tat gcg gcc agc ttc tcc ttg gtg gtc atc tcc tgc atc atg     1920
 Asp Asn Tyr Ala Ala Ser Phe Ser Leu Val Val Ile Ser Cys Ile Met
 625                 630                 635                 640

 tgt gtg gcc atc atg tac atc tac ggg cac cgg aac tac ttc cag gac     1968
 Cys Val Ala Ile Met Tyr Ile Tyr Gly His Arg Asn Tyr Phe Gln Asp
                 645                 650                 655

 atc cag atg atg ctg gga ttc cca cca ccc ctc ttc ttt cag atc tgc     2016
 Ile Gln Met Met Leu Gly Phe Pro Pro Pro Leu Phe Phe Gln Ile Cys
             660                 665                 670

 tgg cgc ttc gtc tct ccc gcc atc atc ttc ttt att cta gtt ttc act     2064
 Trp Arg Phe Val Ser Pro Ala Ile Ile Phe Phe Ile Leu Val Phe Thr
         675                 680                 685

 gtg atc cag tac cag ccg atc acc tac aac cac tac cag tac cca ggc     2112
 Val Ile Gln Tyr Gln Pro Ile Thr Tyr Asn His Tyr Gln Tyr Pro Gly
     690                 695                 700

 tgg gcc gtg gcc att ggc ttc ctc atg gct ctg tcc tcc gtc ctc tgc     2160
 Trp Ala Val Ala Ile Gly Phe Leu Met Ala Leu Ser Ser Val Leu Cys
 705                 710                 715                 720

 atc ccc ctc tac gcc atg ttc cgg ctc tgc cgc aca gac ggg gac acc     2208
 Ile Pro Leu Tyr Ala Met Phe Arg Leu Cys Arg Thr Asp Gly Asp Thr
                 725                 730                 735

 ctc ctc cag cgt ttg aaa aat gcc aca aag cca agc aga gac tgg ggc     2256
 Leu Leu Gln Arg Leu Lys Asn Ala Thr Lys Pro Ser Arg Asp Trp Gly
             740                 745                 750

 cct gcc ctc ctg gag cac cgg aca ggg cgc tac gcc ccc acc ata gcc     2304
 Pro Ala Leu Leu Glu His Arg Thr Gly Arg Tyr Ala Pro Thr Ile Ala
         755                 760                 765

 ccc tct cct gag gac ggc ttc gag gtc cag cca ctg cac ccg gac aag     2352
 Pro Ser Pro Glu Asp Gly Phe Glu Val Gln Pro Leu His Pro Asp Lys
     770                 775                 780

 gcg cag atc ccc att gtg ggc agt aat ggc tcc agc cgc ctc cag gac     2400
 Ala Gln Ile Pro Ile Val Gly Ser Asn Gly Ser Ser Arg Leu Gln Asp
 785                 790                 795                 800

 tcc cgg ata tga                                                     2412
 Ser Arg Ile 






      <210> 873
      <211> 6810
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (1)..(6810)

      <400> 873
  atg gct cct cgc gcc gcg ggc ggc gca ccc ctt agc gcc tgg gcc gcc      48
  Met Ala Pro Arg Ala Ala Gly Gly Ala Pro Leu Ser Ala Trp Ala Ala
    1               5                  10                  15

 gcc gcc agc ccc ccg ccg ttc cag acg ccg ccg cgg tgc ccg gtg ccg       96
 Ala Ala Ser Pro Pro Pro Phe Gln Thr Pro Pro Arg Cys Pro Val Pro
              20                  25                  30

 ctg ctg ttg ctg ctg ctc ctg ggg gcg gcg cgg gcc ggc gcc ctg gag      144
 Leu Leu Leu Leu Leu Leu Leu Gly Ala Ala Arg Ala Gly Ala Leu Glu
          35                  40                  45

 atc cag cgt cgg ttc ccc tcg ccc acg ccc acc aac aac ttc gcc ctg      192
 Ile Gln Arg Arg Phe Pro Ser Pro Thr Pro Thr Asn Asn Phe Ala Leu
      50                  55                  60

 gac ggc gcg gcg ggg acc gtg tac ctg gcg gcc gcc aac cgc ctc tat      240
 Asp Gly Ala Ala Gly Thr Val Tyr Leu Ala Ala Ala Asn Arg Leu Tyr
  65                  70                  75                  80

 cag ctg tcg ggc gcc aac ctg agc ctg gag gcc gag gcg gcc gtg ggc      288
 Gln Leu Ser Gly Ala Asn Leu Ser Leu Glu Ala Glu Ala Ala Val Gly
                  85                  90                  95

 ccg gtg ccc gac agc ccg ctg tgt cac gct tcg cag ctg ccg cag gcc      336
 Pro Val Pro Asp Ser Pro Leu Cys His Ala Ser Gln Leu Pro Gln Ala
             100                 105                 110

 tcg tgc gag cac ccg cgg cgc ctc acg gac aac tac aac aag atc ctg      384
 Ser Cys Glu His Pro Arg Arg Leu Thr Asp Asn Tyr Asn Lys Ile Leu
         115                 120                 125

 cag ctg gac ccc ggc cag ggc ctg gta gtc gtg tgc ggg tcc atc tac      432
 Gln Leu Asp Pro Gly Gln Gly Leu Val Val Val Cys Gly Ser Ile Tyr
     130                 135                 140

 cag ggc ttc tgc cag ctg cgg cgc cgg ggc aac atc tcg gcc gtg gcc      480
 Gln Gly Phe Cys Gln Leu Arg Arg Arg Gly Asn Ile Ser Ala Val Ala
 145                 150                 155                 160

 gtg cgc ttc ccg ccc gcc gcg ccg ccc gcc gag ccc gtc acg gtg ttc      528
 Val Arg Phe Pro Pro Ala Ala Pro Pro Ala Glu Pro Val Thr Val Phe
                 165                 170                 175

 ccc agc atg ctg aac gtg gcg gcc aac cac ccg aac gcg tcc acc gtg      576
 Pro Ser Met Leu Asn Val Ala Ala Asn His Pro Asn Ala Ser Thr Val
             180                 185                 190

 ggg cta gtt ctg cct ccc gcc gcg ggc gcg ggg ggc agc cgc ctg ctc      624
 Gly Leu Val Leu Pro Pro Ala Ala Gly Ala Gly Gly Ser Arg Leu Leu
         195                 200                 205

 gtg ggc gcc acg tac acc ggt tac ggc agc tcc ttc ttc ccg cgc aac      672
 Val Gly Ala Thr Tyr Thr Gly Tyr Gly Ser Ser Phe Phe Pro Arg Asn
     210                 215                 220

 cgc agc ctg gag gac cac cgc ttc gag aac acg ccc gag atc gcc atc      720
 Arg Ser Leu Glu Asp His Arg Phe Glu Asn Thr Pro Glu Ile Ala Ile
 225                 230                 235                 240

 cgc tcc ctg gac acg cgc ggc gac ctg gcc aag ctc ttc acc ttc gac      768
 Arg Ser Leu Asp Thr Arg Gly Asp Leu Ala Lys Leu Phe Thr Phe Asp
                 245                 250                 255

 ctc aac ccc tcc gac gac aac atc ctc aag atc aag cag ggc gcc aag      816
 Leu Asn Pro Ser Asp Asp Asn Ile Leu Lys Ile Lys Gln Gly Ala Lys
             260                 265                 270

 gag cag cac aag ctg ggc ttc gtg agc gcc ttc ctg cac ccg tcc gac      864
 Glu Gln His Lys Leu Gly Phe Val Ser Ala Phe Leu His Pro Ser Asp
         275                 280                 285

 ccg ccg ccg ggt gca cag tcc tac gcg tac ctg gcg ctc aac agc gag      912
 Pro Pro Pro Gly Ala Gln Ser Tyr Ala Tyr Leu Ala Leu Asn Ser Glu
     290                 295                 300

 gcg cgc gcg ggc gac aag gag agc cag gcg cgg agc ctg ctg gcg cgc      960
 Ala Arg Ala Gly Asp Lys Glu Ser Gln Ala Arg Ser Leu Leu Ala Arg
 305                 310                 315                 320

 atc tgc ctg ccc cac ggc gcc ggc ggc gac gcc aag aag ctc acc gag     1008
 Ile Cys Leu Pro His Gly Ala Gly Gly Asp Ala Lys Lys Leu Thr Glu
                 325                 330                 335

 tcc tac atc cag ttg ggc ttg cag tgc gcg ggc ggc gcg ggc cgc ggc     1056
 Ser Tyr Ile Gln Leu Gly Leu Gln Cys Ala Gly Gly Ala Gly Arg Gly
             340                 345                 350

 gac ctc tac agc cgc ctg gtg tcg gtc ttc cca gcc cgg gag cgg ctc     1104
 Asp Leu Tyr Ser Arg Leu Val Ser Val Phe Pro Ala Arg Glu Arg Leu
         355                 360                 365

 ttt gct gtc ttc gag cgg ccc cag ggg tcc ccc gcg gcc cgc gct gct     1152
 Phe Ala Val Phe Glu Arg Pro Gln Gly Ser Pro Ala Ala Arg Ala Ala
     370                 375                 380

 ccg gcc gca ctc tgc gcc ttc cgc ttc gcc gac gtg cga gcc gcc atc     1200
 Pro Ala Ala Leu Cys Ala Phe Arg Phe Ala Asp Val Arg Ala Ala Ile
 385                 390                 395                 400

 cga gct gcg cgc acc gcc tgc ttc gtg gaa ccg gcg ccc gac gtg gtg     1248
 Arg Ala Ala Arg Thr Ala Cys Phe Val Glu Pro Ala Pro Asp Val Val
                 405                 410                 415

 gcg gtg ctc gac agc gtg gtg cag ggc acg gga ccg gcc tgt gag cgc     1296
 Ala Val Leu Asp Ser Val Val Gln Gly Thr Gly Pro Ala Cys Glu Arg
             420                 425                 430

 aag ctc aac atc cag gtc gag gtc ggt ctc cca cga ctg ccc acc atc     1344
 Lys Leu Asn Ile Gln Val Glu Val Gly Leu Pro Arg Leu Pro Thr Ile
         435                 440                 445

 tgg ccg gcc acc ctg aaa gta aag gtc acg agc aca ggc tcc atg ctg     1392
 Trp Pro Ala Thr Leu Lys Val Lys Val Thr Ser Thr Gly Ser Met Leu
     450                 455                 460

 gag aac gtc atg cat gtg ctg cca tgg gaa atg tgt gac cag cac agt     1440
 Glu Asn Val Met His Val Leu Pro Trp Glu Met Cys Asp Gln His Ser
 465                 470                 475                 480

 gcc atc aca gga gtt ggg ggg ctg agc cac atc ttg aaa act tgc cgt     1488
 Ala Ile Thr Gly Val Gly Gly Leu Ser His Ile Leu Lys Thr Cys Arg
                 485                 490                 495

 ctg ggc atg cct gga gag gga aca gca tgg gtc cag aca ccg ggg gcg     1536
 Leu Gly Met Pro Gly Glu Gly Thr Ala Trp Val Gln Thr Pro Gly Ala
             500                 505                 510

 ctg aag tgc caa ggg gag tac gaa tgc ctc aga ggc atg gga tgg gca     1584
 Leu Lys Cys Gln Gly Glu Tyr Glu Cys Leu Arg Gly Met Gly Trp Ala
         515                 520                 525

 ttg gct gct gaa ggg aca ttt aca atg gta caa gag ccc cgg ctc cag     1632
 Leu Ala Ala Glu Gly Thr Phe Thr Met Val Gln Glu Pro Arg Leu Gln
     530                 535                 540

 cca gag cag ctg gac tgt gga gct gct cac ctg cag cac ccg ctg tcc     1680
 Pro Glu Gln Leu Asp Cys Gly Ala Ala His Leu Gln His Pro Leu Ser
 545                 550                 555                 560

 atc ctg cag ccc ctg aag gcc acg ccc gtg ttc cgc gcc ccg ggc ctc     1728
 Ile Leu Gln Pro Leu Lys Ala Thr Pro Val Phe Arg Ala Pro Gly Leu
                 565                 570                 575

 acc tcc gtg gcc gtg gcc agc gtc aac aac tac aca gcg gtc ttc ctg     1776
 Thr Ser Val Ala Val Ala Ser Val Asn Asn Tyr Thr Ala Val Phe Leu
             580                 585                 590

 ggc acg gtc aac ggg agg ctt ctc aag atc aac ctg aac gag agc atg     1824
 Gly Thr Val Asn Gly Arg Leu Leu Lys Ile Asn Leu Asn Glu Ser Met
         595                 600                 605

 cag gtg gtg agc agg cgg gtg gtg act gtg gcc tat ggg gag ccc gtg     1872
 Gln Val Val Ser Arg Arg Val Val Thr Val Ala Tyr Gly Glu Pro Val
     610                 615                 620

 cac cat gtc atg cag ttt gac cca gca gac tcc ggt tac ctt tac ctg     1920
 His His Val Met Gln Phe Asp Pro Ala Asp Ser Gly Tyr Leu Tyr Leu
 625                 630                 635                 640

 atg acg tcc cac cag atg gcc agg gtg aag gtc gcc gcc tgc aac gtg     1968
 Met Thr Ser His Gln Met Ala Arg Val Lys Val Ala Ala Cys Asn Val
                 645                 650                 655

 cac tcc acc tgt ggg gac tgc gtg ggt gcg gcg gac gcc tac tgc ggc     2016
 His Ser Thr Cys Gly Asp Cys Val Gly Ala Ala Asp Ala Tyr Cys Gly
             660                 665                 670

 tgg tgt gcc ctg gag acg cgg tgc acc ttg cag cag gac tgc acc aat     2064
 Trp Cys Ala Leu Glu Thr Arg Cys Thr Leu Gln Gln Asp Cys Thr Asn
         675                 680                 685

 tcc agc cag cag cat ttc tgg acc agt gcc agc gag ggc ccc agc cgc     2112
 Ser Ser Gln Gln His Phe Trp Thr Ser Ala Ser Glu Gly Pro Ser Arg
     690                 695                 700

 tgt cct gcc atg acc gtc ctg cct tcc gag atc gat gtg cgc cag gag     2160
 Cys Pro Ala Met Thr Val Leu Pro Ser Glu Ile Asp Val Arg Gln Glu
 705                 710                 715                 720

 tac cca ggc atg atc ctg cag atc tcg ggc agc ctg ccc agc ctc agt     2208
 Tyr Pro Gly Met Ile Leu Gln Ile Ser Gly Ser Leu Pro Ser Leu Ser
                 725                 730                 735

 ggc atg gag atg gcc tgt gac tat ggg aac aac atc cgc act gtg gct     2256
 Gly Met Glu Met Ala Cys Asp Tyr Gly Asn Asn Ile Arg Thr Val Ala
             740                 745                 750

 cgg gtc cca ggc cct gcc ttt ggt cac cag att gcc tac tgc aac ctc     2304
 Arg Val Pro Gly Pro Ala Phe Gly His Gln Ile Ala Tyr Cys Asn Leu
         755                 760                 765

 ctg ccg agg gac cag ttt ccg ccc ttc ccc ccc aac cag gac cac gtg     2352
 Leu Pro Arg Asp Gln Phe Pro Pro Phe Pro Pro Asn Gln Asp His Val
     770                 775                 780

 act gtt gag atg tct gtg agg gtc aat ggg cgg aac atc gtc aag gcc     2400
 Thr Val Glu Met Ser Val Arg Val Asn Gly Arg Asn Ile Val Lys Ala
 785                 790                 795                 800

 aat ttc acc atc tac gac tgc agc cgc act gca caa gtg tac ccc cac     2448
 Asn Phe Thr Ile Tyr Asp Cys Ser Arg Thr Ala Gln Val Tyr Pro His
                 805                 810                 815

 aca gcc tgt acc agc tgc ctg tcg gca cag tgg ccc tgt ttc tgg tgc     2496
 Thr Ala Cys Thr Ser Cys Leu Ser Ala Gln Trp Pro Cys Phe Trp Cys
             820                 825                 830

 agc cag cag cac tcc tgt gtt tcc aac cag tct cgg tgc gag gcc tca     2544
 Ser Gln Gln His Ser Cys Val Ser Asn Gln Ser Arg Cys Glu Ala Ser
         835                 840                 845

 cca aac ccc acg agc cct cag gac tgc ccc cgg acc ctg ctc tca ccc     2592
 Pro Asn Pro Thr Ser Pro Gln Asp Cys Pro Arg Thr Leu Leu Ser Pro
     850                 855                 860

 ctg gca ccc gtg cct acg ggt ggc tcc cag aac atc ctg gtg cct ctg     2640
 Leu Ala Pro Val Pro Thr Gly Gly Ser Gln Asn Ile Leu Val Pro Leu
 865                 870                 875                 880

 gcc aac act gcc ttt ttc cag ggt gca gcc ctg gag tgt agt ttt ggg     2688
 Ala Asn Thr Ala Phe Phe Gln Gly Ala Ala Leu Glu Cys Ser Phe Gly
                 885                 890                 895

 ctg gag gag atc ttc gag gct gtg tgg gtg aat gag tct gtt gta cgc     2736
 Leu Glu Glu Ile Phe Glu Ala Val Trp Val Asn Glu Ser Val Val Arg
             900                 905                 910

 tgt gac cag gtg gtg ctg cac acg acc cgg aag agc cag gtg ttc ccg     2784
 Cys Asp Gln Val Val Leu His Thr Thr Arg Lys Ser Gln Val Phe Pro
         915                 920                 925

 ctc agc ctc caa cta aag ggg cgg cca gcc cga ttc ctg gac agc cct     2832
 Leu Ser Leu Gln Leu Lys Gly Arg Pro Ala Arg Phe Leu Asp Ser Pro
     930                 935                 940

 gag ccc atg aca gtc atg gtc tat aac tgt gcc atg ggc agc ccc gac     2880
 Glu Pro Met Thr Val Met Val Tyr Asn Cys Ala Met Gly Ser Pro Asp
 945                 950                 955                 960

 tgt tcc cag tgc ctg ggc cgc gaa gac ctg ggt cac ctg tgc atg tgg     2928
 Cys Ser Gln Cys Leu Gly Arg Glu Asp Leu Gly His Leu Cys Met Trp
                 965                 970                 975

 agt gat ggc tgc cgc ctg cgg ggg cct ctg cag ccc atg gct ggc acc     2976
 Ser Asp Gly Cys Arg Leu Arg Gly Pro Leu Gln Pro Met Ala Gly Thr
             980                 985                 990

 tgc ccc gcc ccc gag atc cac gcg tgg gtc tgc acg gct gtg ccc tgc     3024
 Cys Pro Ala Pro Glu Ile His Ala Trp Val Cys Thr Ala Val Pro Cys
         995                1000                1005

 tgg gtg cct gtg act gtg ggc aga agc ctg ctg gcc tgc agc ctc aga     3072
 Trp Val Pro Val Thr Val Gly Arg Ser Leu Leu Ala Cys Ser Leu Arg
    1010                1015                1020

 tcc cat tcg ccc ctc tct cgg gtc acc tgg cag att gag ccc ctg agt     3120
 Ser His Ser Pro Leu Ser Arg Val Thr Trp Gln Ile Glu Pro Leu Ser
1025                1030                1035                1040

 ggc ccg ttg gac ggt ggg acc ctg ctg acc atc cga gga agg aac ctg     3168
 Gly Pro Leu Asp Gly Gly Thr Leu Leu Thr Ile Arg Gly Arg Asn Leu
                1045                1050                1055

 ggc cgg cgg ctc agt gac gtg gcc cac ggc gtg tgg att ggt ggt gtg     3216
 Gly Arg Arg Leu Ser Asp Val Ala His Gly Val Trp Ile Gly Gly Val
            1060                1065                1070

 gcc tgt gag cca ctg cct gac aga tac acg gtg tcg gag gag atc gtg     3264
 Ala Cys Glu Pro Leu Pro Asp Arg Tyr Thr Val Ser Glu Glu Ile Val
        1075                1080                1085

 tgt gtc aca ggg cca gcc cca gga cca ctc tca ggt gtg gtg acc gtg     3312
 Cys Val Thr Gly Pro Ala Pro Gly Pro Leu Ser Gly Val Val Thr Val
    1090                1095                1100

 aac gcc tct aag gag ggc aag tcc cgg gac cgc ttc tcc tac gtg ctg     3360
 Asn Ala Ser Lys Glu Gly Lys Ser Arg Asp Arg Phe Ser Tyr Val Leu
1105                1110                1115                1120

 ccc ctg gtc cac tcc ctg gag cct acc atg ggc ccc aag gcc ggg ggc     3408
 Pro Leu Val His Ser Leu Glu Pro Thr Met Gly Pro Lys Ala Gly Gly
                1125                1130                1135

 acc agg atc acc atc cat ggg aat gac ctc cat gta ggc tcc gag ctc     3456
 Thr Arg Ile Thr Ile His Gly Asn Asp Leu His Val Gly Ser Glu Leu
            1140                1145                1150

 cag gtc ctg gtg aac gac aca gac ccc tgc acg gag ctg atg cgc aca     3504
 Gln Val Leu Val Asn Asp Thr Asp Pro Cys Thr Glu Leu Met Arg Thr
        1155                1160                1165

 gat acc agc atc gcc tgc acc atg cct gag ggg gcc ctg ccg gct ccg     3552
 Asp Thr Ser Ile Ala Cys Thr Met Pro Glu Gly Ala Leu Pro Ala Pro
    1170                1175                1180

 gtg cct gtg tgt gtg cgc ttc gag cgt cgg ggc tgc gtg cac ggc aac     3600
 Val Pro Val Cys Val Arg Phe Glu Arg Arg Gly Cys Val His Gly Asn
1185                1190                1195                1200

 ctc acc ttc tgg tac atg cag aac ccg gtc atc acg gcc atc agt ccc     3648
 Leu Thr Phe Trp Tyr Met Gln Asn Pro Val Ile Thr Ala Ile Ser Pro
                1205                1210                1215

 cgc cgc agc cct gtc agg ctc tct ggg gct gca ggt gca ctg ata ggt     3696
 Arg Arg Ser Pro Val Arg Leu Ser Gly Ala Ala Gly Ala Leu Ile Gly
            1220                1225                1230

 ttt gct gtc ccc cgc agt ggc ggc agg acc atc aca gtg gct ggt gag     3744
 Phe Ala Val Pro Arg Ser Gly Gly Arg Thr Ile Thr Val Ala Gly Glu
        1235                1240                1245

 cgt ttc cac atg gtg cag aat gtg tcc atg gcc gtc cac cac att ggc     3792
 Arg Phe His Met Val Gln Asn Val Ser Met Ala Val His His Ile Gly
    1250                1255                1260

 cgg gag ccc acg ctc tgc aag gtt ctc aac tcc acc ctc atc acc tgc     3840
 Arg Glu Pro Thr Leu Cys Lys Val Leu Asn Ser Thr Leu Ile Thr Cys
1265                1270                1275                1280

 ccg tcc ccc ggg gcc ctg agc aac gca tca gcg cca gtg gac ttc ttc     3888
 Pro Ser Pro Gly Ala Leu Ser Asn Ala Ser Ala Pro Val Asp Phe Phe
                1285                1290                1295

 atc aat ggg cgg gcc tac gca gac gag gtg gct gtg gct gag gag cta     3936
 Ile Asn Gly Arg Ala Tyr Ala Asp Glu Val Ala Val Ala Glu Glu Leu
            1300                1305                1310

 ctg gac ccc gag gag gca cag cgg ggc agc agg ttc cgc ctg gac tac     3984
 Leu Asp Pro Glu Glu Ala Gln Arg Gly Ser Arg Phe Arg Leu Asp Tyr
        1315                1320                1325

 ctc ccc aac cca cag ttc tct acg gcc aag agg gag aag tgg atc aag     4032
 Leu Pro Asn Pro Gln Phe Ser Thr Ala Lys Arg Glu Lys Trp Ile Lys
    1330                1335                1340

 cac cac ccc ggg gag cct ctc acc ctc gtt atc cac gtg agc acc aaa     4080
 His His Pro Gly Glu Pro Leu Thr Leu Val Ile His Val Ser Thr Lys
1345                1350                1355                1360

 ggg gcc ggg aag gag cag gac agc ctg ggg ctc cag agt cac gag tac     4128
 Gly Ala Gly Lys Glu Gln Asp Ser Leu Gly Leu Gln Ser His Glu Tyr
                1365                1370                1375

 cgg gtc aag ata ggc caa gta agc tgc gac atc cag att gtc tct gac     4176
 Arg Val Lys Ile Gly Gln Val Ser Cys Asp Ile Gln Ile Val Ser Asp
            1380                1385                1390

 aga atc atc cac tgc tcg gtc aac gag tcc ctg ggc gcg gcc gtg ggg     4224
 Arg Ile Ile His Cys Ser Val Asn Glu Ser Leu Gly Ala Ala Val Gly
        1395                1400                1405

 cag ctg ccc atc aca atc cag gta ggg aac ttc aac cag acc atc gcc     4272
 Gln Leu Pro Ile Thr Ile Gln Val Gly Asn Phe Asn Gln Thr Ile Ala
    1410                1415                1420

 aca ctg cag ctg ggg ggc agc gag acg gcc atc atc gtg tcc atc gtc     4320
 Thr Leu Gln Leu Gly Gly Ser Glu Thr Ala Ile Ile Val Ser Ile Val
1425                1430                1435                1440

 atc tgc agc gtc ctg ctg ctg ctc tcc gtg gtg gcc ctg ttc gtc ttc     4368
 Ile Cys Ser Val Leu Leu Leu Leu Ser Val Val Ala Leu Phe Val Phe
                1445                1450                1455

 tgt acc aag agc cga cgt gct gag cgt tac tgg cag aag acg ctg ctg     4416
 Cys Thr Lys Ser Arg Arg Ala Glu Arg Tyr Trp Gln Lys Thr Leu Leu
            1460                1465                1470

 cag atg gag gag atg gaa tct cag atc cga gag gaa atc cgc aaa ggg     4464
 Gln Met Glu Glu Met Glu Ser Gln Ile Arg Glu Glu Ile Arg Lys Gly
        1475                1480                1485

 gat ggg ttc tcg ggc cgc tca cgg ctg tcc gtg tgt ccg cca ggc ttc     4512
 Asp Gly Phe Ser Gly Arg Ser Arg Leu Ser Val Cys Pro Pro Gly Phe
    1490                1495                1500

 gct gag ctg cag aca gac atg aca gat ctc acc aag gag ctg aac cgc     4560
 Ala Glu Leu Gln Thr Asp Met Thr Asp Leu Thr Lys Glu Leu Asn Arg
1505                1510                1515                1520

 agc cag ggc atc ccc ttc ctg gag tat aag cac ttc gtg acc cgc acc     4608
 Ser Gln Gly Ile Pro Phe Leu Glu Tyr Lys His Phe Val Thr Arg Thr
                1525                1530                1535

 ttc ttc ccc aag tgt tcc tcc ctt tat gaa gag cgt tac gtg ctg ccc     4656
 Phe Phe Pro Lys Cys Ser Ser Leu Tyr Glu Glu Arg Tyr Val Leu Pro
            1540                1545                1550

 tcc cag acc ctc aac tcc cag ggc agc tcc cag gca cag gaa acc cac     4704
 Ser Gln Thr Leu Asn Ser Gln Gly Ser Ser Gln Ala Gln Glu Thr His
        1555                1560                1565

 cca ctg ctg gga gag tgg aag att cct gag agc tgc cgg ccc aac atg     4752
 Pro Leu Leu Gly Glu Trp Lys Ile Pro Glu Ser Cys Arg Pro Asn Met
    1570                1575                1580

 gaa gag gga att agc ttg ttc tcc tca cta ctc aac aac aag cac ttc     4800
 Glu Glu Gly Ile Ser Leu Phe Ser Ser Leu Leu Asn Asn Lys His Phe
1585                1590                1595                1600

 ctc atc gtc ttt gtc cac gcg ctg gag cag cag aag gac ttt gcg gtg     4848
 Leu Ile Val Phe Val His Ala Leu Glu Gln Gln Lys Asp Phe Ala Val
                1605                1610                1615

 cgc gac agg tgc agc ctg gcc tcg ctg ctg acc atc gcg ctg cac ggc     4896
 Arg Asp Arg Cys Ser Leu Ala Ser Leu Leu Thr Ile Ala Leu His Gly
            1620                1625                1630

 aag ctg gag tac tac acc agc atc atg aag gag ctg ctg gtg gac ctc     4944
 Lys Leu Glu Tyr Tyr Thr Ser Ile Met Lys Glu Leu Leu Val Asp Leu
        1635                1640                1645

 att gac gcc tcg gcc gcc aag aac ccc aag ctc atg ctg cgg cgc aca     4992
 Ile Asp Ala Ser Ala Ala Lys Asn Pro Lys Leu Met Leu Arg Arg Thr
    1650                1655                1660

 gag tct gtg gtg gag aag atg ctc acc aac tgg atg tcc atc tgc atg     5040
 Glu Ser Val Val Glu Lys Met Leu Thr Asn Trp Met Ser Ile Cys Met
1665                1670                1675                1680

 tac agc tgt ctg cgg gag acg gtg ggg gag cca ttc ttc ctg ctg ctg     5088
 Tyr Ser Cys Leu Arg Glu Thr Val Gly Glu Pro Phe Phe Leu Leu Leu
                1685                1690                1695

 tgt gcc atc aag cag caa atc aac aag ggc tcc atc gac gcc atc aca     5136
 Cys Ala Ile Lys Gln Gln Ile Asn Lys Gly Ser Ile Asp Ala Ile Thr
            1700                1705                1710

 ggc aag gcc cgc tac aca ctc aat gag gag tgg ctg ctg cgg gag aac     5184
 Gly Lys Ala Arg Tyr Thr Leu Asn Glu Glu Trp Leu Leu Arg Glu Asn
        1715                1720                1725

 atc gag gcc aag ccc cgg aac ctg aac gtg tcc ttc cag ggc tgt ggc     5232
 Ile Glu Ala Lys Pro Arg Asn Leu Asn Val Ser Phe Gln Gly Cys Gly
    1730                1735                1740

 atg gac tcg ctg agc gtg cgg gcc atg gac acc gac acg ctg aca cag     5280
 Met Asp Ser Leu Ser Val Arg Ala Met Asp Thr Asp Thr Leu Thr Gln
1745                1750                1755                1760

 gtc aag gag aag atc ctg gag gcc ttc tgc aag aat gtg ccc tac tcc     5328
 Val Lys Glu Lys Ile Leu Glu Ala Phe Cys Lys Asn Val Pro Tyr Ser
                1765                1770                1775

 cag tgg ccg cgt gca gag gac gtc gac ctt gag tgg ttc gcc tcc agc     5376
 Gln Trp Pro Arg Ala Glu Asp Val Asp Leu Glu Trp Phe Ala Ser Ser
            1780                1785                1790

 aca cag agc tac atc ctt cgg gac ctg gac gac acc tca gtg gtg gaa     5424
 Thr Gln Ser Tyr Ile Leu Arg Asp Leu Asp Asp Thr Ser Val Val Glu
        1795                1800                1805

 gac ggc cgc aag aag ctt aac acg ctg gcc cat tac aag atc cct gaa     5472
 Asp Gly Arg Lys Lys Leu Asn Thr Leu Ala His Tyr Lys Ile Pro Glu
    1810                1815                1820

 ggt gcc tcc ctg gcc atg agt ctc ata gac aag aag gac aac aca ctg     5520
 Gly Ala Ser Leu Ala Met Ser Leu Ile Asp Lys Lys Asp Asn Thr Leu
1825                1830                1835                1840

 ggc cga gtg aaa gac ttg gac aca gag aag tat ttc cat ttg gtg ctg     5568
 Gly Arg Val Lys Asp Leu Asp Thr Glu Lys Tyr Phe His Leu Val Leu
                1845                1850                1855

 cct acg gac gag ctg gcg gag ccc aag aag tct cac cgg cag agc cat     5616
 Pro Thr Asp Glu Leu Ala Glu Pro Lys Lys Ser His Arg Gln Ser His
            1860                1865                1870

 cgc aag aag gtg ctc ccg gaa atc tac ctg acc cgc ctg ctc tcc acc     5664
 Arg Lys Lys Val Leu Pro Glu Ile Tyr Leu Thr Arg Leu Leu Ser Thr
        1875                1880                1885

 aag ggc acg ttg cag aag ttt ctg gat gac ctg ttc aag gcc att ctg     5712
 Lys Gly Thr Leu Gln Lys Phe Leu Asp Asp Leu Phe Lys Ala Ile Leu
    1890                1895                1900

 agt atc cgt gaa gac aag ccc cca ctg gct gtc aag tac ttt ttc gac     5760
 Ser Ile Arg Glu Asp Lys Pro Pro Leu Ala Val Lys Tyr Phe Phe Asp
1905                1910                1915                1920

 ttc ctg gag gag cag gct gag aag agg gga atc tcc gac ccc gac acc     5808
 Phe Leu Glu Glu Gln Ala Glu Lys Arg Gly Ile Ser Asp Pro Asp Thr
                1925                1930                1935

 cta cac atc tgg aag acc aac agc ctt cct ctc cgg ttc tgg gtg aac     5856
 Leu His Ile Trp Lys Thr Asn Ser Leu Pro Leu Arg Phe Trp Val Asn
            1940                1945                1950

 atc ctg aag aac ccc cag ttt gtc ttt gac atc gac aag aca gac cac     5904
 Ile Leu Lys Asn Pro Gln Phe Val Phe Asp Ile Asp Lys Thr Asp His
        1955                1960                1965

 atc gac gcc tgc ctt tca gtc atc gcg cag gcc ttc atc gac gcc tgc     5952
 Ile Asp Ala Cys Leu Ser Val Ile Ala Gln Ala Phe Ile Asp Ala Cys
    1970                1975                1980

 tcc atc tct gac ctg cag ctg ggc aag gat tcg cca acc aac aag ctc     6000
 Ser Ile Ser Asp Leu Gln Leu Gly Lys Asp Ser Pro Thr Asn Lys Leu
1985                1990                1995                2000

 ctc tac gcc aag gag att cct gag tac cgg aag atc gtg cag cgc tac     6048
 Leu Tyr Ala Lys Glu Ile Pro Glu Tyr Arg Lys Ile Val Gln Arg Tyr
                2005                2010                2015

 tac aag cag atc cag gac atg acg ccg ctc agc gag caa gag atg aat     6096
 Tyr Lys Gln Ile Gln Asp Met Thr Pro Leu Ser Glu Gln Glu Met Asn
            2020                2025                2030

 gcc cat ctg gcc gag gag tcg agg gtg cgg tgg ctc ggc ggc ggg gga     6144
 Ala His Leu Ala Glu Glu Ser Arg Val Arg Trp Leu Gly Gly Gly Gly
        2035                2040                2045

 tgg ggg cct gaa gag ctg agg gat cgg ggg tcg ggg gct ggg cct caa     6192
 Trp Gly Pro Glu Glu Leu Arg Asp Arg Gly Ser Gly Ala Gly Pro Gln
    2050                2055                2060

 tgc ctc cac tgg agt aag ggc agg gag cgc aga ggg cat ttc aga agt     6240
 Cys Leu His Trp Ser Lys Gly Arg Glu Arg Arg Gly His Phe Arg Ser
2065                2070                2075                2080

 ggc tgt ggc ctc ttg ctg gcc tgc aaa ttc gtc atg cat ttt ccc aga     6288
 Gly Cys Gly Leu Leu Leu Ala Cys Lys Phe Val Met His Phe Pro Arg
                2085                2090                2095

 aaa tac cag aat gag ttc aac acc aat gtg gcc atg gca gag att tat     6336
 Lys Tyr Gln Asn Glu Phe Asn Thr Asn Val Ala Met Ala Glu Ile Tyr
            2100                2105                2110

 aag tac gcc aag agg tat cgg ccg cag atc atg gcc gcg ctg gag gcc     6384
 Lys Tyr Ala Lys Arg Tyr Arg Pro Gln Ile Met Ala Ala Leu Glu Ala
        2115                2120                2125

 aac ccc acg gcc cgg agg aca caa ctg cag cac aag ttt gag cag gtg     6432
 Asn Pro Thr Ala Arg Arg Thr Gln Leu Gln His Lys Phe Glu Gln Val
    2130                2135                2140

 gtg gct ttg atg gag gac aac atc tac gag tgc tac agg aaa gat ctc     6480
 Val Ala Leu Met Glu Asp Asn Ile Tyr Glu Cys Tyr Arg Lys Asp Leu
2145                2150                2155                2160

 gag agc cag ctc caa agg ggc gct tac ttt gaa gct gcc agt ggc ccc     6528
 Glu Ser Gln Leu Gln Arg Gly Ala Tyr Phe Glu Ala Ala Ser Gly Pro
                2165                2170                2175

 cct ggc ttt gga gtt gag ggg cct ggc gag gag gcc acg gcg cat gcc     6576
 Pro Gly Phe Gly Val Glu Gly Pro Gly Glu Glu Ala Thr Ala His Ala
            2180                2185                2190

 agt ggc cag cgc ctg ctt cag cag aag gtt agg ggc ccc tcc tct ggg     6624
 Ser Gly Gln Arg Leu Leu Gln Gln Lys Val Arg Gly Pro Ser Ser Gly
        2195                2200                2205

 ctc tgc cag gcc cca gcc ttg ctc ctg gag agc ctc aag cgc tct gaa     6672
 Leu Cys Gln Ala Pro Ala Leu Leu Leu Glu Ser Leu Lys Arg Ser Glu
    2210                2215                2220

 tcg cag ctc tgc ttc cgt gtc tcc agc ctt tgc gct ctg gtt gag gag     6720
 Ser Gln Leu Cys Phe Arg Val Ser Ser Leu Cys Ala Leu Val Glu Glu
2225                2230                2235                2240

 cag ggc tgt atc tgt ctt gtt cct ggt ggt atc cct ggt gcc cag cac     6768
 Gln Gly Cys Ile Cys Leu Val Pro Gly Gly Ile Pro Gly Ala Gln His
                2245                2250                2255

 agc acc tgg cac acg gtc ggt gct cag tac cca tta ctg tga             6810
 Ser Thr Trp His Thr Val Gly Ala Gln Tyr Pro Leu Leu 
            2260                2265





      <210> 874
      <211> 2619
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (1)..(2619)

      <400> 874
  atg gcc tgg ctc cct gcc tat gct aca tgc cag atg ttt gcc cac ctc      48
  Met Ala Trp Leu Pro Ala Tyr Ala Thr Cys Gln Met Phe Ala His Leu
    1               5                  10                  15

 acc caa gag ccc tgc tca gtt gcc aag cag ccc tgg agc ctc acg ttg       96
 Thr Gln Glu Pro Cys Ser Val Ala Lys Gln Pro Trp Ser Leu Thr Leu
              20                  25                  30

 ccc ggc ccc aca ttc tgt gcc cca gaa tgt ggc tgc cag agc cca gat      144
 Pro Gly Pro Thr Phe Cys Ala Pro Glu Cys Gly Cys Gln Ser Pro Asp
          35                  40                  45

 gtt tca gcc ctc ccc tca ccc aca tcc aca ctg ccc gca gca tcc tgg      192
 Val Ser Ala Leu Pro Ser Pro Thr Ser Thr Leu Pro Ala Ala Ser Trp
      50                  55                  60

 cca ggt agt gcc atg ggc ctg gct gcc gct tcc tgc tcc tcg tcc tac      240
 Pro Gly Ser Ala Met Gly Leu Ala Ala Ala Ser Cys Ser Ser Ser Tyr
  65                  70                  75                  80

 ccc aac aca cct gca tgg aac atg cgt cag tgt gtg tgc atc agt gtg      288
 Pro Asn Thr Pro Ala Trp Asn Met Arg Gln Cys Val Cys Ile Ser Val
                  85                  90                  95

 cat ctc tat gtg tca tgc act ggt gtg tct tcg tgt ata tca gtg tgt      336
 His Leu Tyr Val Ser Cys Thr Gly Val Ser Ser Cys Ile Ser Val Cys
             100                 105                 110

 gtc tac gtg acg cct gct ttg gtg tat gtc tat acg cgg ttc ctt gtt      384
 Val Tyr Val Thr Pro Ala Leu Val Tyr Val Tyr Thr Arg Phe Leu Val
         115                 120                 125

 gtg tgc ctg gat acc atg ggg ttg tgt gtc tgt gcc ttg tgt gca ctg      432
 Val Cys Leu Asp Thr Met Gly Leu Cys Val Cys Ala Leu Cys Ala Leu
     130                 135                 140

 gtg tcc gag tgt gct ttg tgt tcg aag gcg gaa cgt gtg gcc agg cgt      480
 Val Ser Glu Cys Ala Leu Cys Ser Lys Ala Glu Arg Val Ala Arg Arg
 145                 150                 155                 160

 tct gga cgt gac atg tgt ggc ggg gtc cga gtc ccg ctg cgt gtc agc      528
 Ser Gly Arg Asp Met Cys Gly Gly Val Arg Val Pro Leu Arg Val Ser
                 165                 170                 175

 gtg tgt ctg cgc tgg aac gcg ggc cag cac gtg tca ggg cgg ccg cgt      576
 Val Cys Leu Arg Trp Asn Ala Gly Gln His Val Ser Gly Arg Pro Arg
             180                 185                 190

 cga ccc acg acc atc gac gag cct aca gac cta cgg aca cag gaa acc      624
 Arg Pro Thr Thr Ile Asp Glu Pro Thr Asp Leu Arg Thr Gln Glu Thr
         195                 200                 205

 gac gac ttg tgt tca cac tgt cac aca cac cca tta aca cac acg cac      672
 Asp Asp Leu Cys Ser His Cys His Thr His Pro Leu Thr His Thr His
     210                 215                 220

 ctc ttg aaa tgg gac acg tat att ggt gta ggc tta gcg aca cag cag      720
 Leu Leu Lys Trp Asp Thr Tyr Ile Gly Val Gly Leu Ala Thr Gln Gln
 225                 230                 235                 240

 tac ctc ttt gac gca cgt atg gac aca gga aac tgt gga ctt gtg ttc      768
 Tyr Leu Phe Asp Ala Arg Met Asp Thr Gly Asn Cys Gly Leu Val Phe
                 245                 250                 255

 aca acc acc ccc agc gca cac ata aac act cac aaa ccc ctc gag atg      816
 Thr Thr Thr Pro Ser Ala His Ile Asn Thr His Lys Pro Leu Glu Met
             260                 265                 270

 ata cag ata gcg acg aag gca cat gga gac cac gac acc tcc cag act      864
 Ile Gln Ile Ala Thr Lys Ala His Gly Asp His Asp Thr Ser Gln Thr
         275                 280                 285

 cat gga gcc ctg agc aca tgc ttg gat aca ggt cca aac atc ctc tcc      912
 His Gly Ala Leu Ser Thr Cys Leu Asp Thr Gly Pro Asn Ile Leu Ser
     290                 295                 300

 cac acc ttg ctg ggc acc cag ccg gag ctc aaa tgc tgg ggg tgc agc      960
 His Thr Leu Leu Gly Thr Gln Pro Glu Leu Lys Cys Trp Gly Cys Ser
 305                 310                 315                 320

 cgg gag cct gtg cat tcc ttc gac aaa tat tta cca agc acc tcc tgg     1008
 Arg Glu Pro Val His Ser Phe Asp Lys Tyr Leu Pro Ser Thr Ser Trp
                 325                 330                 335

 gtg cca ggc tct gtt tta ggc ccc ggg ggc tcg gca ggg agc aaa atc     1056
 Val Pro Gly Ser Val Leu Gly Pro Gly Gly Ser Ala Gly Ser Lys Ile
             340                 345                 350

 tgc aaa gat gcc agc ccc ggc gcc aac ctc act tcc aaa ccc gcc gcc     1104
 Cys Lys Asp Ala Ser Pro Gly Ala Asn Leu Thr Ser Lys Pro Ala Ala
         355                 360                 365

 atc gtt ggc tct ctg gcc ttc tct gcc gcc tgg ggc tgg gac ctg gaa     1152
 Ile Val Gly Ser Leu Ala Phe Ser Ala Ala Trp Gly Trp Asp Leu Glu
     370                 375                 380

 atg gga att tgg ggg tgg ggg ccg ggc ctg tgg aca tca ggg gct ttc     1200
 Met Gly Ile Trp Gly Trp Gly Pro Gly Leu Trp Thr Ser Gly Ala Phe
 385                 390                 395                 400

 tgc gtg ctc ggc tgc atc cct aaa ggt gag tcc cta aaa gtg ggc tct     1248
 Cys Val Leu Gly Cys Ile Pro Lys Gly Glu Ser Leu Lys Val Gly Ser
                 405                 410                 415

 gag cac agg gcc tgg tat aca agc aat gct cca gtg tcg gca ggc att     1296
 Glu His Arg Ala Trp Tyr Thr Ser Asn Ala Pro Val Ser Ala Gly Ile
             420                 425                 430

 tct gcc agt cct gac ccc ata aac ctg gtc tcc gct ggc cct gcc cag     1344
 Ser Ala Ser Pro Asp Pro Ile Asn Leu Val Ser Ala Gly Pro Ala Gln
         435                 440                 445

 gcc tgg agc tca ggg aaa acg tgg gaa aca ggc ata ggg tgg agc ccc     1392
 Ala Trp Ser Ser Gly Lys Thr Trp Glu Thr Gly Ile Gly Trp Ser Pro
     450                 455                 460

 act gaa tcc gat gga aaa gcc aag gcc caa gag gaa acc gga cga cga     1440
 Thr Glu Ser Asp Gly Lys Ala Lys Ala Gln Glu Glu Thr Gly Arg Arg
 465                 470                 475                 480

 aaa ggc ggg aag cgg cgc ttc gag gcc ccg gat gtc aga cgc gac ctg     1488
 Lys Gly Gly Lys Arg Arg Phe Glu Ala Pro Asp Val Arg Arg Asp Leu
                 485                 490                 495

 tgt ggc atg tac cag gct ggc tcc gac gac gga acc gcc atg ggt gct     1536
 Cys Gly Met Tyr Gln Ala Gly Ser Asp Asp Gly Thr Ala Met Gly Ala
             500                 505                 510

 gag tgg aga gtg ggg acc gcg gac ccc ggg ggc agt ttt ctc ttg tgt     1584
 Glu Trp Arg Val Gly Thr Ala Asp Pro Gly Gly Ser Phe Leu Leu Cys
         515                 520                 525

 gtg ctg aat cgg gtc ata gag gga gac ttc ccg tgc aaa cag ttt gtg     1632
 Val Leu Asn Arg Val Ile Glu Gly Asp Phe Pro Cys Lys Gln Phe Val
     530                 535                 540

 ttg gag ctg aag gac gca gag ggg gag aga ggg ata agc agc agg gcc     1680
 Leu Glu Leu Lys Asp Ala Glu Gly Glu Arg Gly Ile Ser Ser Arg Ala
 545                 550                 555                 560

 cct tcc ctg gct gcc cag tgc tgc cgc tgc gtc atg tct gca gtt ccc     1728
 Pro Ser Leu Ala Ala Gln Cys Cys Arg Cys Val Met Ser Ala Val Pro
                 565                 570                 575

 ttc cca tct ctg gcc gct gtc tgg cca ctg tct tct tgt ggc ctt cca     1776
 Phe Pro Ser Leu Ala Ala Val Trp Pro Leu Ser Ser Cys Gly Leu Pro
             580                 585                 590

 cga agc agc agt aat ctt ggg aca aga tgt ttc act ata ggc ctc aag     1824
 Arg Ser Ser Ser Asn Leu Gly Thr Arg Cys Phe Thr Ile Gly Leu Lys
         595                 600                 605

 cat ggc tgc tcc ata gct cta act gga gag acc ccc tca gaa gtg gga     1872
 His Gly Cys Ser Ile Ala Leu Thr Gly Glu Thr Pro Ser Glu Val Gly
     610                 615                 620

 ctc ccc tac cca gtg ctc acc ctt tct gct tgc tgt gag gaa ggt ccc     1920
 Leu Pro Tyr Pro Val Leu Thr Leu Ser Ala Cys Cys Glu Glu Gly Pro
 625                 630                 635                 640

 caa gtg gag gac cag agc agg ggc tcc ccg gat gag ttc cac ccg ttc     1968
 Gln Val Glu Asp Gln Ser Arg Gly Ser Pro Asp Glu Phe His Pro Phe
                 645                 650                 655

 atc gag gca ctg ctg cct cac gtc cgc gct ttc tcc tac acc tgg ttc     2016
 Ile Glu Ala Leu Leu Pro His Val Arg Ala Phe Ser Tyr Thr Trp Phe
             660                 665                 670

 aac ctg cag gcg cgg aag cgc aag tac ttc aag aag cat gaa aag cgg     2064
 Asn Leu Gln Ala Arg Lys Arg Lys Tyr Phe Lys Lys His Glu Lys Arg
         675                 680                 685

 atg tcg aag gac gag gag cgg gcg gtg aag gac gag ctg ctg ggc gag     2112
 Met Ser Lys Asp Glu Glu Arg Ala Val Lys Asp Glu Leu Leu Gly Glu
     690                 695                 700

 aag ccc gag atc aag cag aag tgg gca tcc cgg ctg ctg gcc aag ctg     2160
 Lys Pro Glu Ile Lys Gln Lys Trp Ala Ser Arg Leu Leu Ala Lys Leu
 705                 710                 715                 720

 cgc aag gac atc cgg ccc gag ttc cgc gag gac ttc gtg ctg acc atc     2208
 Arg Lys Asp Ile Arg Pro Glu Phe Arg Glu Asp Phe Val Leu Thr Ile
                 725                 730                 735

 acg ggc aag aag ccc ccc tgc tgc gtg ctc tcc aac ccc gac cag aag     2256
 Thr Gly Lys Lys Pro Pro Cys Cys Val Leu Ser Asn Pro Asp Gln Lys
             740                 745                 750

 ggc aag atc cgg cgg att gac tgc ctg cgc cag gct gac aag gtg tgg     2304
 Gly Lys Ile Arg Arg Ile Asp Cys Leu Arg Gln Ala Asp Lys Val Trp
         755                 760                 765

 cgg ctg gac ctg gtc atg gtg att ttg ttt aag ggg atc ccc ctg gaa     2352
 Arg Leu Asp Leu Val Met Val Ile Leu Phe Lys Gly Ile Pro Leu Glu
     770                 775                 780

 agt act gat ggg gag cgg ctc tac aag tcg cct cag tgc tcg aac ccc     2400
 Ser Thr Asp Gly Glu Arg Leu Tyr Lys Ser Pro Gln Cys Ser Asn Pro
 785                 790                 795                 800

 ggc ctg tgc gtc cag cca cat cac att gga gtc aca atc aaa gaa ctg     2448
 Gly Leu Cys Val Gln Pro His His Ile Gly Val Thr Ile Lys Glu Leu
                 805                 810                 815

 gat ctt tat ctg gct tac ttt gtc cac act ccg gca agc cag att tgg     2496
 Asp Leu Tyr Leu Ala Tyr Phe Val His Thr Pro Ala Ser Gln Ile Trp
             820                 825                 830

 gag ggt gtg tgc ctg gta gta ttg gag gtg act ggt ggc ttg cag aag     2544
 Glu Gly Val Cys Leu Val Val Leu Glu Val Thr Gly Gly Leu Gln Lys
         835                 840                 845

 gct cgg agc ctc gag ctt acc agt gtg gcc atc aga tac tcc tgc aca     2592
 Ala Arg Ser Leu Glu Leu Thr Ser Val Ala Ile Arg Tyr Ser Cys Thr
     850                 855                 860

 agg gga ttc tgc acc ttc caa ttt tag                                 2619
 Arg Gly Phe Cys Thr Phe Gln Phe 
 865                 870





      <210> 875
      <211> 2865
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (1)..(2865)

      <400> 875
  atg aac gga ctg cct gtt cct ggc cgt gga gtg cat ttt gca ctc acg      48
  Met Asn Gly Leu Pro Val Pro Gly Arg Gly Val His Phe Ala Leu Thr
    1               5                  10                  15

 ttt gca cga act cta gcc tca tgg ttc tca gac atg ggt atg cat cag       96
 Phe Ala Arg Thr Leu Ala Ser Trp Phe Ser Asp Met Gly Met His Gln
              20                  25                  30

 aat gac cca gat gca tta aaa aca ctg cca ggt ccc agc ccc aga gct      144
 Asn Asp Pro Asp Ala Leu Lys Thr Leu Pro Gly Pro Ser Pro Arg Ala
          35                  40                  45

 tct gat tca gcg ggg ctg ggc acc cag cac aat act tgg aac ata agc      192
 Ser Asp Ser Ala Gly Leu Gly Thr Gln His Asn Thr Trp Asn Ile Ser
      50                  55                  60

 cag aca cgt tca ttg agc acc att tct gct gca ccc atg aaa aaa aca      240
 Gln Thr Arg Ser Leu Ser Thr Ile Ser Ala Ala Pro Met Lys Lys Thr
  65                  70                  75                  80

 ctc aac cca gac aga tgg tta gct ccc cga cag gac tta agc aag atc      288
 Leu Asn Pro Asp Arg Trp Leu Ala Pro Arg Gln Asp Leu Ser Lys Ile
                  85                  90                  95

 atg gga gac cac ctg gac ctt ctc cta gga gtg gtg ctc atg gcc ggt      336
 Met Gly Asp His Leu Asp Leu Leu Leu Gly Val Val Leu Met Ala Gly
             100                 105                 110

 cct gtg ttt gga att cct tcc tgc tcc ttt gat ggc cga ata gcc ttt      384
 Pro Val Phe Gly Ile Pro Ser Cys Ser Phe Asp Gly Arg Ile Ala Phe
         115                 120                 125

 tat cgt ttc tgc aac ctc acc cag gtc ccc cag gtc ctc aac acc act      432
 Tyr Arg Phe Cys Asn Leu Thr Gln Val Pro Gln Val Leu Asn Thr Thr
     130                 135                 140

 gag agg ctc ctg ctg agc ttc aac tat atc agg aca gtc act gct tca      480
 Glu Arg Leu Leu Leu Ser Phe Asn Tyr Ile Arg Thr Val Thr Ala Ser
 145                 150                 155                 160

 tcc ttc ccc ttt ctg gaa cag ctg cag ctg ctg gag ctc ggg agc cag      528
 Ser Phe Pro Phe Leu Glu Gln Leu Gln Leu Leu Glu Leu Gly Ser Gln
                 165                 170                 175

 tat acc ccc ttg act att gac aag gag gcc ttc aga aac ctg ccc aac      576
 Tyr Thr Pro Leu Thr Ile Asp Lys Glu Ala Phe Arg Asn Leu Pro Asn
             180                 185                 190

 ctt aga atc ttg gac ctg gga agt agt aag ata tac ttc ttg cat cca      624
 Leu Arg Ile Leu Asp Leu Gly Ser Ser Lys Ile Tyr Phe Leu His Pro
         195                 200                 205

 gat gct ttt cag gga ctg ttc cat ctg ttt gaa ctt aga ctg tat ttc      672
 Asp Ala Phe Gln Gly Leu Phe His Leu Phe Glu Leu Arg Leu Tyr Phe
     210                 215                 220

 tgt ggt ctc tct gat gct gta ttg aaa gat ggt tat ttc aga aat tta      720
 Cys Gly Leu Ser Asp Ala Val Leu Lys Asp Gly Tyr Phe Arg Asn Leu
 225                 230                 235                 240

 aag gct tta act cgc ttg gat cta tcc aaa aat cag att cgt agc ctt      768
 Lys Ala Leu Thr Arg Leu Asp Leu Ser Lys Asn Gln Ile Arg Ser Leu
                 245                 250                 255

 tac ctt cat cct tca ttt ggg aag ttg aat tcc tta aag tcc ata gat      816
 Tyr Leu His Pro Ser Phe Gly Lys Leu Asn Ser Leu Lys Ser Ile Asp
             260                 265                 270

 ttt tcc tcc aac caa ata ttc ctt gta tgt gaa cat gag ctc gag ccc      864
 Phe Ser Ser Asn Gln Ile Phe Leu Val Cys Glu His Glu Leu Glu Pro
         275                 280                 285

 cta caa ggg aaa acg ctc tcc ttt ttt agc ctc gca gct aat agc ttg      912
 Leu Gln Gly Lys Thr Leu Ser Phe Phe Ser Leu Ala Ala Asn Ser Leu
     290                 295                 300

 tat agc aga gtc tca gtg gac tgg gga aaa tgt atg aac cca ttc aga      960
 Tyr Ser Arg Val Ser Val Asp Trp Gly Lys Cys Met Asn Pro Phe Arg
 305                 310                 315                 320

 aac atg gtg ctg gag ata cta gat gtt tct gga aat ggc tgg aca gtg     1008
 Asn Met Val Leu Glu Ile Leu Asp Val Ser Gly Asn Gly Trp Thr Val
                 325                 330                 335

 gac atc aca gga aac ttt agc aat gcc atc agc aaa agc cag gcc ttc     1056
 Asp Ile Thr Gly Asn Phe Ser Asn Ala Ile Ser Lys Ser Gln Ala Phe
             340                 345                 350

 tct ttg att ctt gcc cac cac atc atg ggt gcc ggg ttt ggc ttc cat     1104
 Ser Leu Ile Leu Ala His His Ile Met Gly Ala Gly Phe Gly Phe His
         355                 360                 365

 aac atc aaa gat cct gac cag aac aca ttt gct ggc ctg gcc aga agt     1152
 Asn Ile Lys Asp Pro Asp Gln Asn Thr Phe Ala Gly Leu Ala Arg Ser
     370                 375                 380

 tca gtg aga cac ctg gat ctt tca cat ggg ttt gtc ttc tcc ctg aac     1200
 Ser Val Arg His Leu Asp Leu Ser His Gly Phe Val Phe Ser Leu Asn
 385                 390                 395                 400

 tca cga gtc ttt gag aca ctc aag gat ttg aag gtt ctg aac ctt gcc     1248
 Ser Arg Val Phe Glu Thr Leu Lys Asp Leu Lys Val Leu Asn Leu Ala
                 405                 410                 415

 tac aac aag ata aat aag att gca gat gaa gca ttt tac gga ctt gac     1296
 Tyr Asn Lys Ile Asn Lys Ile Ala Asp Glu Ala Phe Tyr Gly Leu Asp
             420                 425                 430

 aac ctc caa gtt ctc aat ttg tca tat aac ctt ctg ggg gaa ctt tac     1344
 Asn Leu Gln Val Leu Asn Leu Ser Tyr Asn Leu Leu Gly Glu Leu Tyr
         435                 440                 445

 agt tcg aat ttc tat gga cta cct aag gta gcc tac att gat ttg caa     1392
 Ser Ser Asn Phe Tyr Gly Leu Pro Lys Val Ala Tyr Ile Asp Leu Gln
     450                 455                 460

 aag aat cac att gca ata att caa gac caa aca ttc aaa ttc ctg gaa     1440
 Lys Asn His Ile Ala Ile Ile Gln Asp Gln Thr Phe Lys Phe Leu Glu
 465                 470                 475                 480

 aaa tta cag acc ttg gat ctc cga gac aat gct ctt aca acc att cat     1488
 Lys Leu Gln Thr Leu Asp Leu Arg Asp Asn Ala Leu Thr Thr Ile His
                 485                 490                 495

 ttt att cca agc ata ccc gat atc ttc ttg agt ggc aat aaa cta gtg     1536
 Phe Ile Pro Ser Ile Pro Asp Ile Phe Leu Ser Gly Asn Lys Leu Val
             500                 505                 510

 act ttg cca aag atc aac ctt aca gcg aac ctc atc cac tta tca gaa     1584
 Thr Leu Pro Lys Ile Asn Leu Thr Ala Asn Leu Ile His Leu Ser Glu
         515                 520                 525

 aac agg cta gaa aat cta gat att ctc tac ttt ctt cta cgg gta cct     1632
 Asn Arg Leu Glu Asn Leu Asp Ile Leu Tyr Phe Leu Leu Arg Val Pro
     530                 535                 540

 cat ctc cag att ctc att tta aat caa aat cgc ttc tcc tcc tgt agt     1680
 His Leu Gln Ile Leu Ile Leu Asn Gln Asn Arg Phe Ser Ser Cys Ser
 545                 550                 555                 560

 gga gat caa acc cct tca gag aat ccc agc tta gaa cag ctt ttc ctt     1728
 Gly Asp Gln Thr Pro Ser Glu Asn Pro Ser Leu Glu Gln Leu Phe Leu
                 565                 570                 575

 gga gaa aat atg ttg caa ctt gcc tgg gaa act gag ctc tgt tgg gat     1776
 Gly Glu Asn Met Leu Gln Leu Ala Trp Glu Thr Glu Leu Cys Trp Asp
             580                 585                 590

 gtt ttt gag gga ctt tct cat ctt caa gtt ctg tat ttg aat cat aac     1824
 Val Phe Glu Gly Leu Ser His Leu Gln Val Leu Tyr Leu Asn His Asn
         595                 600                 605

 tat ctt aat tcc ctt cca cca gga gta ttt agc cat ctg act gca tta     1872
 Tyr Leu Asn Ser Leu Pro Pro Gly Val Phe Ser His Leu Thr Ala Leu
     610                 615                 620

 agg gga cta agc ctc aac tcc aac agg ctg aca gtt ctt tct cac aat     1920
 Arg Gly Leu Ser Leu Asn Ser Asn Arg Leu Thr Val Leu Ser His Asn
 625                 630                 635                 640

 gat tta cct gct aat tta gag atc ctg gac ata tcc agg aac cag ctc     1968
 Asp Leu Pro Ala Asn Leu Glu Ile Leu Asp Ile Ser Arg Asn Gln Leu
                 645                 650                 655

 cta gct cct aat cct gat gta ttt gta tca ctt agt gtc ttg gat ata     2016
 Leu Ala Pro Asn Pro Asp Val Phe Val Ser Leu Ser Val Leu Asp Ile
             660                 665                 670

 act cat aac aag ttc att tgt gaa tgt gaa ctt agc act ttt atc aat     2064
 Thr His Asn Lys Phe Ile Cys Glu Cys Glu Leu Ser Thr Phe Ile Asn
         675                 680                 685

 tgg ctt aat cac acc aat gtc act ata gct ggg cct cct gca gac ata     2112
 Trp Leu Asn His Thr Asn Val Thr Ile Ala Gly Pro Pro Ala Asp Ile
     690                 695                 700

 tat tgt gtg tac cct gac tcg ttc tct ggg gtt tcc ctc ttc tct ctt     2160
 Tyr Cys Val Tyr Pro Asp Ser Phe Ser Gly Val Ser Leu Phe Ser Leu
 705                 710                 715                 720

 tcc acg gaa ggt tgt gat gaa gag gaa gtc tta aag tcc cta aag ttc     2208
 Ser Thr Glu Gly Cys Asp Glu Glu Glu Val Leu Lys Ser Leu Lys Phe
                 725                 730                 735

 tcc ctt ttc att gta tgc act gtc act ctg act ctg ttc ctc atg acc     2256
 Ser Leu Phe Ile Val Cys Thr Val Thr Leu Thr Leu Phe Leu Met Thr
             740                 745                 750

 atc ctc aca gtc aca aag ttc cgg ggc ttc tgt ttt atc tgt tat aag     2304
 Ile Leu Thr Val Thr Lys Phe Arg Gly Phe Cys Phe Ile Cys Tyr Lys
         755                 760                 765

 aca gcc cag aga ctg gtg ttc aag gac cat ccc cag ggc aca gaa cct     2352
 Thr Ala Gln Arg Leu Val Phe Lys Asp His Pro Gln Gly Thr Glu Pro
     770                 775                 780

 gat atg tac aaa tat gat gcc tat ttg tgc ttc agc agc aaa gac ttc     2400
 Asp Met Tyr Lys Tyr Asp Ala Tyr Leu Cys Phe Ser Ser Lys Asp Phe
 785                 790                 795                 800

 aca tgg gtg cag aat gct ttg ctc aaa cac ctg gac act caa tac agt     2448
 Thr Trp Val Gln Asn Ala Leu Leu Lys His Leu Asp Thr Gln Tyr Ser
                 805                 810                 815

 gac caa aac aga ttc aac ctg tgc ttt gaa gaa aga gac ttt gtc cca     2496
 Asp Gln Asn Arg Phe Asn Leu Cys Phe Glu Glu Arg Asp Phe Val Pro
             820                 825                 830

 gga gaa aac cgc att gcc aat atc cag gat gcc atc tgg aac agt aga     2544
 Gly Glu Asn Arg Ile Ala Asn Ile Gln Asp Ala Ile Trp Asn Ser Arg
         835                 840                 845

 aag atc gtt tgt ctt gtg agc aga cac ttc ctt aga gat ggc tgg tgc     2592
 Lys Ile Val Cys Leu Val Ser Arg His Phe Leu Arg Asp Gly Trp Cys
     850                 855                 860

 ctt gaa gcc ttc agt tat gcc cag ggc agg tgc tta tct gac ctt aac     2640
 Leu Glu Ala Phe Ser Tyr Ala Gln Gly Arg Cys Leu Ser Asp Leu Asn
 865                 870                 875                 880

 agt gct ctc atc atg gtg gtg gtt ggg tcc ttg tcc cag tac cag ttg     2688
 Ser Ala Leu Ile Met Val Val Val Gly Ser Leu Ser Gln Tyr Gln Leu
                 885                 890                 895

 atg aaa cat caa tcc atc aga ggc ttt gta cag aaa cag cag tat ttg     2736
 Met Lys His Gln Ser Ile Arg Gly Phe Val Gln Lys Gln Gln Tyr Leu
             900                 905                 910

 agg tgg cct gag gat ctc cag gat gtt ggc tgg ttt ctt cat aaa ctc     2784
 Arg Trp Pro Glu Asp Leu Gln Asp Val Gly Trp Phe Leu His Lys Leu
         915                 920                 925

 tct caa cag ata cta aag aaa gaa aaa gaa aag aag aaa gac aat aac     2832
 Ser Gln Gln Ile Leu Lys Lys Glu Lys Glu Lys Lys Lys Asp Asn Asn
     930                 935                 940

 att ccg ttg caa act gta gca acc atc tcc taa                         2865
 Ile Pro Leu Gln Thr Val Ala Thr Ile Ser 
 945                 950





      <210> 876
      <211> 1104
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (1)..(1104)

      <400> 876
  atg acg gcc ggc ggc cag gcc gag gcc gag ggc gct ggc ggg gag ccc      48
  Met Thr Ala Gly Gly Gln Ala Glu Ala Glu Gly Ala Gly Gly Glu Pro
    1               5                  10                  15

 ggc gcg gcg cgg ctg ccc tcg cgg gtg gcc cgg ctg ctg tcg gcg ctc       96
 Gly Ala Ala Arg Leu Pro Ser Arg Val Ala Arg Leu Leu Ser Ala Leu
              20                  25                  30

 ttc tac ggg acc tgc tcc ttc ctc atc gtg ctt gtc aac aag gcg ctg      144
 Phe Tyr Gly Thr Cys Ser Phe Leu Ile Val Leu Val Asn Lys Ala Leu
          35                  40                  45

 ctg acc acc tac ggt ttc ccg tca cca att ttc ctt gga att gga cag      192
 Leu Thr Thr Tyr Gly Phe Pro Ser Pro Ile Phe Leu Gly Ile Gly Gln
      50                  55                  60

 atg gca gcc acc ata atg ata cta tat gtg tcc aag cta aac aaa atc      240
 Met Ala Ala Thr Ile Met Ile Leu Tyr Val Ser Lys Leu Asn Lys Ile
  65                  70                  75                  80

 att cac ttc cct gat ttt gat aag aaa att cct gta aag ctg ctc tct      288
 Ile His Phe Pro Asp Phe Asp Lys Lys Ile Pro Val Lys Leu Leu Ser
                  85                  90                  95

 gga tgc agt gtg gtt gat gat gtg aag cct gtg ctg ggg aag cag tat      336
 Gly Cys Ser Val Val Asp Asp Val Lys Pro Val Leu Gly Lys Gln Tyr
             100                 105                 110

 tca ctc aac atc atc ctc agt gtc ttt gcc att att ctc ggg gct ttc      384
 Ser Leu Asn Ile Ile Leu Ser Val Phe Ala Ile Ile Leu Gly Ala Phe
         115                 120                 125

 ata gca gct ggg tct gac ctt gct ttt aac tta gaa ggc tat att ttt      432
 Ile Ala Ala Gly Ser Asp Leu Ala Phe Asn Leu Glu Gly Tyr Ile Phe
     130                 135                 140

 gta ttc ctg aat gat atc ttc aca gca gca aat gga gtt tat acc aaa      480
 Val Phe Leu Asn Asp Ile Phe Thr Ala Ala Asn Gly Val Tyr Thr Lys
 145                 150                 155                 160

 cag aaa atg gac cca aag gag cta ggg aaa tac gga gta ctt ttc tac      528
 Gln Lys Met Asp Pro Lys Glu Leu Gly Lys Tyr Gly Val Leu Phe Tyr
                 165                 170                 175

 aat gcc tgc ttc atg att atc cca act ctt att att agt gtc tcc act      576
 Asn Ala Cys Phe Met Ile Ile Pro Thr Leu Ile Ile Ser Val Ser Thr
             180                 185                 190

 gga gac ctg caa cag ctt ttt gtt cct ctg gag tat ttt aaa acc tat      624
 Gly Asp Leu Gln Gln Leu Phe Val Pro Leu Glu Tyr Phe Lys Thr Tyr
         195                 200                 205

 ccc agc cat cac gcc att tta cct cta aat att cca gga tcc aca ttt      672
 Pro Ser His His Ala Ile Leu Pro Leu Asn Ile Pro Gly Ser Thr Phe
     210                 215                 220

 gaa ttt tgg gaa ggt gtt gtt ctt tca gca ttt gcc ctg aaa ccg tat      720
 Glu Phe Trp Glu Gly Val Val Leu Ser Ala Phe Ala Leu Lys Pro Tyr
 225                 230                 235                 240

 ctg ctg ctg gtt tct gct gat gta ctc cac ggt tct gtg cag cta tta      768
 Leu Leu Leu Val Ser Ala Asp Val Leu His Gly Ser Val Gln Leu Leu
                 245                 250                 255

 caa ttc agc cct gac gac agc agt ggt tgg agc cat caa gaa tgt atc      816
 Gln Phe Ser Pro Asp Asp Ser Ser Gly Trp Ser His Gln Glu Cys Ile
             260                 265                 270

 cgt tgc cta cat tgg gat att aat cgg tgg aga cta cat ttt ctc ttt      864
 Arg Cys Leu His Trp Asp Ile Asn Arg Trp Arg Leu His Phe Leu Phe
         275                 280                 285

 gtt aaa ctt tgt agg gtt aaa tat ttg gtt tgt tca gga gct ttt acc      912
 Val Lys Leu Cys Arg Val Lys Tyr Leu Val Cys Ser Gly Ala Phe Thr
     290                 295                 300

 aca ggt gca ttt cct cac atg ctc acc tac cgc caa ccc ctg gtg tat      960
 Thr Gly Ala Phe Pro His Met Leu Thr Tyr Arg Gln Pro Leu Val Tyr
 305                 310                 315                 320

 ggg aag gag gcc caa atg gat agg ctc gac ttg gtg gaa gtt ctg cct     1008
 Gly Lys Glu Ala Gln Met Asp Arg Leu Asp Leu Val Glu Val Leu Pro
                 325                 330                 335

 cag gtg ggc ata gcc aaa aag ggg tca ttc tct tct cgg ttc ctg ggg     1056
 Gln Val Gly Ile Ala Lys Lys Gly Ser Phe Ser Ser Arg Phe Leu Gly
             340                 345                 350

 aat tgg atc caa ctg gga gaa gac cac ctg aat tct cat ccc atc taa     1104
 Asn Trp Ile Gln Leu Gly Glu Asp His Leu Asn Ser His Pro Ile 
         355                 360                 365





      <210> 877
      <211> 927
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (1)..(927)

      <400> 877
  atg ttg cag cag gat agt aat gat gac act aaa gat gtt tca ctg ttt      48
  Met Leu Gln Gln Asp Ser Asn Asp Asp Thr Lys Asp Val Ser Leu Phe
    1               5                  10                  15

 gat gcg gaa gag gag acg act aat aga cca aga aaa gtc aaa atc aga       96
 Asp Ala Glu Glu Glu Thr Thr Asn Arg Pro Arg Lys Val Lys Ile Arg
              20                  25                  30

 cat cca gta gca tcg ttt ttc cac tta ttc ttt cga gtc agt gca atc      144
 His Pro Val Ala Ser Phe Phe His Leu Phe Phe Arg Val Ser Ala Ile
          35                  40                  45

 atc gtc tgt ctt ctc tgt gaa ttg ctc agc agc agc ttt att acc tgt      192
 Ile Val Cys Leu Leu Cys Glu Leu Leu Ser Ser Ser Phe Ile Thr Cys
      50                  55                  60

 atg gta aca att atc ttg ttg tca tgt gac ttt tgg gca gtg aag aat      240
 Met Val Thr Ile Ile Leu Leu Ser Cys Asp Phe Trp Ala Val Lys Asn
  65                  70                  75                  80

 atc aca ggt aga cta atg gtt ggc cta cgt tgg tgg aat cac gtt gat      288
 Ile Thr Gly Arg Leu Met Val Gly Leu Arg Trp Trp Asn His Val Asp
                  85                  90                  95

 gaa gat gga aag agc cac tgg gtg ttt gaa tct aga aag gag tcc tct      336
 Glu Asp Gly Lys Ser His Trp Val Phe Glu Ser Arg Lys Glu Ser Ser
             100                 105                 110

 caa gag aat gaa act gtg tca gag gct gaa tca gga atc ttt tgg ttg      384
 Gln Glu Asn Glu Thr Val Ser Glu Ala Glu Ser Gly Ile Phe Trp Leu
         115                 120                 125

 gga ctt gtt gcc tgt cca gtg ctg tgg gtg ata ctt gcc ttc agt gca      432
 Gly Leu Val Ala Cys Pro Val Leu Trp Val Ile Leu Ala Phe Ser Ala
     130                 135                 140

 cgc ttc tcc ttc aga gta aaa agt ggt tgg cgg tgg tta tcg tgg gtg      480
 Arg Phe Ser Phe Arg Val Lys Ser Gly Trp Arg Trp Leu Ser Trp Val
 145                 150                 155                 160

 tgg tgc tac aag gtg cca acc tgt atg gtt acc tca ggt gta agg tac      528
 Trp Cys Tyr Lys Val Pro Thr Cys Met Val Thr Ser Gly Val Arg Tyr
                 165                 170                 175

 cta gtg tca gaa ttg aat cat tgg aca ccc agt tgg gca tcc aga att      576
 Leu Val Ser Glu Leu Asn His Trp Thr Pro Ser Trp Ala Ser Arg Ile
             180                 185                 190

 gga gaa ttg gtt ggt atg agg gaa aag ccc aca cat ctg gtg tca gaa      624
 Gly Glu Leu Val Gly Met Arg Glu Lys Pro Thr His Leu Val Ser Glu
         195                 200                 205

 gtg ttg gaa ata gaa aca gat cag aat gac acg cat ccg tgt ttg ctc      672
 Val Leu Glu Ile Glu Thr Asp Gln Asn Asp Thr His Pro Cys Leu Leu
     210                 215                 220

 cag ctg agg ctg caa caa agg agg acg aga gaa caa cta gtg gac cag      720
 Gln Leu Arg Leu Gln Gln Arg Arg Thr Arg Glu Gln Leu Val Asp Gln
 225                 230                 235                 240

 ggc atc atg cca caa aca ttt gca gag cca tcc ctg cag gct act cag      768
 Gly Ile Met Pro Gln Thr Phe Ala Glu Pro Ser Leu Gln Ala Thr Gln
                 245                 250                 255

 atg aag ttg aaa aga gct cga cta gca gat gat ctg aat gaa aag att      816
 Met Lys Leu Lys Arg Ala Arg Leu Ala Asp Asp Leu Asn Glu Lys Ile
             260                 265                 270

 gct caa aga cct ggt cct atg gag ctg gta gag aaa aac atc ctt cct      864
 Ala Gln Arg Pro Gly Pro Met Glu Leu Val Glu Lys Asn Ile Leu Pro
         275                 280                 285

 gtg gac tcc agt gtt aaa gaa gca att ata ggc aag act cta aaa att      912
 Val Asp Ser Ser Val Lys Glu Ala Ile Ile Gly Lys Thr Leu Lys Ile
     290                 295                 300

 tac tat ttg ggg tga                                                  927
 Tyr Tyr Leu Gly 
 305





      <210> 878
      <211> 1623
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (1)..(1623)

      <400> 878
  atg gcg ctc acc atc gct act ggt ttc gtg gtg gat gac gcc atc gtg      48
  Met Ala Leu Thr Ile Ala Thr Gly Phe Val Val Asp Asp Ala Ile Val
    1               5                  10                  15

 gtg ctg gaa aac att gca cgt cat ctg gaa gcg gga atg aaa ccg ttg       96
 Val Leu Glu Asn Ile Ala Arg His Leu Glu Ala Gly Met Lys Pro Leu
              20                  25                  30

 caa gcc gca ctg caa ggt act cgc gaa gtc ggt ttt acg gtg ctg tcg      144
 Gln Ala Ala Leu Gln Gly Thr Arg Glu Val Gly Phe Thr Val Leu Ser
          35                  40                  45

 atg agt ctg tca ctg gtg gcg gtg ttc ctg ccg ctg ctg ttg atg ggc      192
 Met Ser Leu Ser Leu Val Ala Val Phe Leu Pro Leu Leu Leu Met Gly
      50                  55                  60

 gga ttg ccg ggc cga ctg tta cgc gaa ttt gcc gtg acg ctt tct gtc      240
 Gly Leu Pro Gly Arg Leu Leu Arg Glu Phe Ala Val Thr Leu Ser Val
  65                  70                  75                  80

 gcc att ggt ata tcg ttg ctg gtt tct ctg aca tta acg cca atg atg      288
 Ala Ile Gly Ile Ser Leu Leu Val Ser Leu Thr Leu Thr Pro Met Met
                  85                  90                  95

 tgt ggc tgg atg ctg aaa gcc agc aag ccg cgc gag caa aag cga ctg      336
 Cys Gly Trp Met Leu Lys Ala Ser Lys Pro Arg Glu Gln Lys Arg Leu
             100                 105                 110

 cgt ggt ttt ggt cgc atg ttg gta gcc ctg caa caa ggc tac ggc aag      384
 Arg Gly Phe Gly Arg Met Leu Val Ala Leu Gln Gln Gly Tyr Gly Lys
         115                 120                 125

 tca cta aaa tgg gtg ctc aat cat acc cgt ctg gtg ggc gtg gtg ctg      432
 Ser Leu Lys Trp Val Leu Asn His Thr Arg Leu Val Gly Val Val Leu
     130                 135                 140

 ctt ggc acc att gcg ctg aat atc tgg ctg tat atc tcg atc ccg aaa      480
 Leu Gly Thr Ile Ala Leu Asn Ile Trp Leu Tyr Ile Ser Ile Pro Lys
 145                 150                 155                 160

 acc ttc ttc ccg gag cag gac act ggc gtg ttg atg ggc ggg att cag      528
 Thr Phe Phe Pro Glu Gln Asp Thr Gly Val Leu Met Gly Gly Ile Gln
                 165                 170                 175

 gcg gat cag agt att tcg ttt cag gcg atg cgc ggt aag ttg cag gat      576
 Ala Asp Gln Ser Ile Ser Phe Gln Ala Met Arg Gly Lys Leu Gln Asp
             180                 185                 190

 ttc atg aaa att atc cgt gac gat ccg gca gtg gat aat gtc acc ggc      624
 Phe Met Lys Ile Ile Arg Asp Asp Pro Ala Val Asp Asn Val Thr Gly
         195                 200                 205

 ttt aca ggc ggt tcg cga gtg aac agc ggg atg atg ttt atc acc ctc      672
 Phe Thr Gly Gly Ser Arg Val Asn Ser Gly Met Met Phe Ile Thr Leu
     210                 215                 220

 aag cca cgc gac gaa cgc agc gaa acg gcg cag caa att atc gac cgt      720
 Lys Pro Arg Asp Glu Arg Ser Glu Thr Ala Gln Gln Ile Ile Asp Arg
 225                 230                 235                 240

 ctg cgc gta aaa ctg gcg aaa gaa ccg ggg gcg aat ctg ttc ctg atg      768
 Leu Arg Val Lys Leu Ala Lys Glu Pro Gly Ala Asn Leu Phe Leu Met
                 245                 250                 255

 gcg gta cag gat att cgc gtt ggt ggg cgt cag tcg aac gcc agc tac      816
 Ala Val Gln Asp Ile Arg Val Gly Gly Arg Gln Ser Asn Ala Ser Tyr
             260                 265                 270

 cag tac acg ttg tta tcc gac gac ctg gcg gca ctg cga gaa tgg gag      864
 Gln Tyr Thr Leu Leu Ser Asp Asp Leu Ala Ala Leu Arg Glu Trp Glu
         275                 280                 285

 ccg aaa atc cgc aaa aaa ctg gcg acg ttg ccg gaa ctg gcg gac gtg      912
 Pro Lys Ile Arg Lys Lys Leu Ala Thr Leu Pro Glu Leu Ala Asp Val
     290                 295                 300

 aac tcc gat cag cag gat aac ggc gcg gag atg aat ctg gtt tac gac      960
 Asn Ser Asp Gln Gln Asp Asn Gly Ala Glu Met Asn Leu Val Tyr Asp
 305                 310                 315                 320

 cgc gac acc atg gca cgg ctg gga atc gac gta caa gcc gcc aac agt     1008
 Arg Asp Thr Met Ala Arg Leu Gly Ile Asp Val Gln Ala Ala Asn Ser
                 325                 330                 335

 ctg tta aat aac gcc ttc ggt cag cgg caa atc tcg acc att tac cag     1056
 Leu Leu Asn Asn Ala Phe Gly Gln Arg Gln Ile Ser Thr Ile Tyr Gln
             340                 345                 350

 ccg atg aac cag tat aaa gtg gtg atg gaa gtg gat ccg cgc tat acc     1104
 Pro Met Asn Gln Tyr Lys Val Val Met Glu Val Asp Pro Arg Tyr Thr
         355                 360                 365

 cag gac atc agt gcg ctg gaa aaa atg ttc gtt atc aat aac gaa ggc     1152
 Gln Asp Ile Ser Ala Leu Glu Lys Met Phe Val Ile Asn Asn Glu Gly
     370                 375                 380

 aaa gcg atc ccg ctg tcg tat ttc gct aaa tgg caa ccg gcg aat gcc     1200
 Lys Ala Ile Pro Leu Ser Tyr Phe Ala Lys Trp Gln Pro Ala Asn Ala
 385                 390                 395                 400

 cca cta tcg gtg aat cat cag gga tta tcg gcg gcc tcg acc att tcg     1248
 Pro Leu Ser Val Asn His Gln Gly Leu Ser Ala Ala Ser Thr Ile Ser
                 405                 410                 415

 ttt aac ctg ccg acc gga aaa tcg ctc tcg gac gcc agt gcg gcg atc     1296
 Phe Asn Leu Pro Thr Gly Lys Ser Leu Ser Asp Ala Ser Ala Ala Ile
             420                 425                 430

 gat cgc gca atg acc cag ctt ggt gtg cct tcg acg gtg cgc ggc agt     1344
 Asp Arg Ala Met Thr Gln Leu Gly Val Pro Ser Thr Val Arg Gly Ser
         435                 440                 445

 ttt gcc ggc acg ggc gca ggt gtt cca gga gac gat gaa ctc gca ggt     1392
 Phe Ala Gly Thr Gly Ala Gly Val Pro Gly Asp Asp Glu Leu Ala Gly
     450                 455                 460

 gat cct gat tat cgc cgc cat cgc cac ggt gta tat cgt gct ggg tat     1440
 Asp Pro Asp Tyr Arg Arg His Arg His Gly Val Tyr Arg Ala Gly Tyr
 465                 470                 475                 480

 cct tta cga gag tta cgt aca tcc gct gac gat tct ctc cac cct gcc     1488
 Pro Leu Arg Glu Leu Arg Thr Ser Ala Asp Asp Ser Leu His Pro Ala
                 485                 490                 495

 ctc ggc ggg cgt tgg agc gct gtt ggc gct gga gct gtt caa tgc ccc     1536
 Leu Gly Gly Arg Trp Ser Ala Val Gly Ala Gly Ala Val Gln Cys Pro
             500                 505                 510

 gtt cag cct aat cgc cct gat agg gat cat gct att aat cgg cat cgt     1584
 Val Gln Pro Asn Arg Pro Asp Arg Asp His Ala Ile Asn Arg His Arg
         515                 520                 525

 gaa gaa aaa cgc cat tat gat ggt cgg ttt tgc gct tga                 1623
 Glu Glu Lys Arg His Tyr Asp Gly Arg Phe Cys Ala 
     530                 535                 540





      <210> 879
      <211> 612
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (1)..(612)

      <400> 879
  atg acg ctg ttg atc gcc acc gtt gga att gat ctc tcc gta ggg ccg      48
  Met Thr Leu Leu Ile Ala Thr Val Gly Ile Asp Leu Ser Val Gly Pro
    1               5                  10                  15

 ttg atg gct atc gcc gga gcc aca acg gct gcg atg acg gtc gcg gga       96
 Leu Met Ala Ile Ala Gly Ala Thr Thr Ala Ala Met Thr Val Ala Gly
              20                  25                  30

 ttc agc ctg ccg att gtt ttg tta agc gcc ctg ggc acc ggc atc ctg      144
 Phe Ser Leu Pro Ile Val Leu Leu Ser Ala Leu Gly Thr Gly Ile Leu
          35                  40                  45

 gcg gga ttg tgg aac ggc ata ctg gta gcg atc ctc aaa att cag ccg      192
 Ala Gly Leu Trp Asn Gly Ile Leu Val Ala Ile Leu Lys Ile Gln Pro
      50                  55                  60

 ttt gtc gcc act ctg atc ctg atg gtc gcc ggg cgc ggc gtg gcg caa      240
 Phe Val Ala Thr Leu Ile Leu Met Val Ala Gly Arg Gly Val Ala Gln
  65                  70                  75                  80

 ctg atc acc gcc ggg cag atc gtc acg ttt aac tcg ccg gat ctc tca      288
 Leu Ile Thr Ala Gly Gln Ile Val Thr Phe Asn Ser Pro Asp Leu Ser
                  85                  90                  95

 tgg ttc ggc agt gga tcg ctg ttg ttc ctg cca acg ccg gtc att atc      336
 Trp Phe Gly Ser Gly Ser Leu Leu Phe Leu Pro Thr Pro Val Ile Ile
             100                 105                 110

 gcg gtg ctg acg ctt atc ctg ttc tgg ctg ttg acc cgc aaa acg gcg      384
 Ala Val Leu Thr Leu Ile Leu Phe Trp Leu Leu Thr Arg Lys Thr Ala
         115                 120                 125

 ctg ggg atg ttt atc gaa gcc gtt ggt atc aac att cgg gcg gca aaa      432
 Leu Gly Met Phe Ile Glu Ala Val Gly Ile Asn Ile Arg Ala Ala Lys
     130                 135                 140

 aat gcc ggg gta aac acg cga atc atc gtc atg ctc act tat gtg ttg      480
 Asn Ala Gly Val Asn Thr Arg Ile Ile Val Met Leu Thr Tyr Val Leu
 145                 150                 155                 160

 agc ggg ctg tgt gcg gcg att gcg ggc att atc gtg gcg gcg gat att      528
 Ser Gly Leu Cys Ala Ala Ile Ala Gly Ile Ile Val Ala Ala Asp Ile
                 165                 170                 175

 cgc ggt gcc gat gcc aac aac gct ggg ctt atg gct gga gct gac gcc      576
 Arg Gly Ala Asp Ala Asn Asn Ala Gly Leu Met Ala Gly Ala Asp Ala
             180                 185                 190

 att act cgc ggt ggt gat ctg gcg gcg gat cgc tga                      612
 Ile Thr Arg Gly Gly Asp Leu Ala Ala Asp Arg 
         195                 200





      <210> 880
      <211> 582
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (1)..(582)

      <400> 880
  atg ggg tgg ccg ccg tgt ggt cgt act atg gtg cac tgg tgg tcg cag      48
  Met Gly Trp Pro Pro Cys Gly Arg Thr Met Val His Trp Trp Ser Gln
    1               5                  10                  15

 aaa gaa cgt ggc ggc att gtg tca gtg tgg aac tgt gcg cac aac gtc       96
 Lys Glu Arg Gly Gly Ile Val Ser Val Trp Asn Cys Ala His Asn Val
              20                  25                  30

 ggt ggt ggt att ccg ccg ctg ctg ttc ctg ctg ggg atg gcc tgg ttc      144
 Gly Gly Gly Ile Pro Pro Leu Leu Phe Leu Leu Gly Met Ala Trp Phe
          35                  40                  45

 aat gac tgg cat gcg gcg ctc tat atg cct gct ttc tgc gcc att ctg      192
 Asn Asp Trp His Ala Ala Leu Tyr Met Pro Ala Phe Cys Ala Ile Leu
      50                  55                  60

 gtg gca tta ttc gcc ttt gcg atg atg cgc gat acc ccg caa tcc tgt      240
 Val Ala Leu Phe Ala Phe Ala Met Met Arg Asp Thr Pro Gln Ser Cys
  65                  70                  75                  80

 ggc ttg ccg ccg atc gaa gag tac aaa aat gat tat ccg gac gac tat      288
 Gly Leu Pro Pro Ile Glu Glu Tyr Lys Asn Asp Tyr Pro Asp Asp Tyr
                  85                  90                  95

 aac gaa aaa gcg gaa cag gag ctg acg gcg aag caa atc ttc atg cag      336
 Asn Glu Lys Ala Glu Gln Glu Leu Thr Ala Lys Gln Ile Phe Met Gln
             100                 105                 110

 tac gta ctg ccg aac aaa ctg ctg tgg tat atc gcc atc gcc aac gtg      384
 Tyr Val Leu Pro Asn Lys Leu Leu Trp Tyr Ile Ala Ile Ala Asn Val
         115                 120                 125

 ttc gtt tat ctg ctg cgt tac ggc atc ctc gac tgg tca ccg act tat      432
 Phe Val Tyr Leu Leu Arg Tyr Gly Ile Leu Asp Trp Ser Pro Thr Tyr
     130                 135                 140

 ctg aaa gag gtt aag cat ttc gcg cta gat aaa tcc tcc tgg gcc tac      480
 Leu Lys Glu Val Lys His Phe Ala Leu Asp Lys Ser Ser Trp Ala Tyr
 145                 150                 155                 160

 ttc ctt tat gaa tat gca ggt att ccg ggc act ctg ctg tgc ggc tgg      528
 Phe Leu Tyr Glu Tyr Ala Gly Ile Pro Gly Thr Leu Leu Cys Gly Trp
                 165                 170                 175

 atg tcg gat aaa gtc ttc cgt ggc aac cgt ggg gca acc ggc gtt tct      576
 Met Ser Asp Lys Val Phe Arg Gly Asn Arg Gly Ala Thr Gly Val Ser
             180                 185                 190

 tta tga                                                              582
 Leu 






      <210> 881
      <211> 3762
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (1)..(3762)

      <400> 881
  atg agt gcg cgc atg ttt gtc tta tgc tgc atc tgg ttt att gtg gcg      48
  Met Ser Ala Arg Met Phe Val Leu Cys Cys Ile Trp Phe Ile Val Ala
    1               5                  10                  15

 ttc ctc tgg ata acc atc act tcc gcg ctg gac aaa gag tgg atg att       96
 Phe Leu Trp Ile Thr Ile Thr Ser Ala Leu Asp Lys Glu Trp Met Ile
              20                  25                  30

 gat gga cgc ggg att aac aac gtc tgc gat gtg ttg atg tat ctc gaa      144
 Asp Gly Arg Gly Ile Asn Asn Val Cys Asp Val Leu Met Tyr Leu Glu
          35                  40                  45

 gaa gac gat acc cgt gat gtt ggt gtg ata atg acg tta ccg ctc ttt      192
 Glu Asp Asp Thr Arg Asp Val Gly Val Ile Met Thr Leu Pro Leu Phe
      50                  55                  60

 ttc cct ttt ctc tgg ttc gct ttg tgg cga aaa aaa cgc ggc tgt aaa      240
 Phe Pro Phe Leu Trp Phe Ala Leu Trp Arg Lys Lys Arg Gly Cys Lys
  65                  70                  75                  80

 gcg atg agt att ctg gta ttc ccg ttt gtt ggc gta ctg atg ctg ctg      288
 Ala Met Ser Ile Leu Val Phe Pro Phe Val Gly Val Leu Met Leu Leu
                  85                  90                  95

 gct ctg tac ctg atc ccg cag tgg aac ggc gct gca ctg gaa acg ctg      336
 Ala Leu Tyr Leu Ile Pro Gln Trp Asn Gly Ala Ala Leu Glu Thr Leu
             100                 105                 110

 tct ctg gac act gca tct gca acc gga aac ggt ctg tgg atg acc ctc      384
 Ser Leu Asp Thr Ala Ser Ala Thr Gly Asn Gly Leu Trp Met Thr Leu
         115                 120                 125

 tgg ctg gca att ccg gtc gag gat gtg cct ggg aaa aag aaa cac aag      432
 Trp Leu Ala Ile Pro Val Glu Asp Val Pro Gly Lys Lys Lys His Lys
     130                 135                 140

 tct cag atc cta ctg cag cgt ttc gtc aat gac atg ggc gct aaa gcc      480
 Ser Gln Ile Leu Leu Gln Arg Phe Val Asn Asp Met Gly Ala Lys Ala
 145                 150                 155                 160

 aat caa aac cag cga cgg ata ttg ctg tgc cag ttg tcg ggc aag cgt      528
 Asn Gln Asn Gln Arg Arg Ile Leu Leu Cys Gln Leu Ser Gly Lys Arg
                 165                 170                 175

 aat gcc gtc gat atc cgg cag atc aaa atc cac cag tgc ggc agc aaa      576
 Asn Ala Val Asp Ile Arg Gln Ile Lys Ile His Gln Cys Gly Ser Lys
             180                 185                 190

 cgc aat gtt cat gca ctg aat cgc cac cgc gaa cag ctg gcg gcg cag      624
 Arg Asn Val His Ala Leu Asn Arg His Arg Glu Gln Leu Ala Ala Gln
         195                 200                 205

 gtc aaa gcg cgt aca gct gaa ttg cag gaa ctg gtg ata gaa cac cga      672
 Val Lys Ala Arg Thr Ala Glu Leu Gln Glu Leu Val Ile Glu His Arg
     210                 215                 220

 cag gca cgg gcg gaa gca gaa aaa gcc agc cag gca aaa tcg gcg ttt      720
 Gln Ala Arg Ala Glu Ala Glu Lys Ala Ser Gln Ala Lys Ser Ala Phe
 225                 230                 235                 240

 ctg gcg gcg atg agc cat gag atc cgc aca ccg ctg tac ggc gca gaa      768
 Leu Ala Ala Met Ser His Glu Ile Arg Thr Pro Leu Tyr Gly Ala Glu
                 245                 250                 255

 cag agc gtg cat aat gac tgg aaa gcg acg cag atc aaa gtg gaa gat      816
 Gln Ser Val His Asn Asp Trp Lys Ala Thr Gln Ile Lys Val Glu Asp
             260                 265                 270

 gta ctg ttt gcg atg gtg aaa gaa gta gaa aat cgc cca gct gtt tcg      864
 Val Leu Phe Ala Met Val Lys Glu Val Glu Asn Arg Pro Ala Val Ser
         275                 280                 285

 ctg aaa acc agc ccg gag ctg gcg gag ctg cta cgt cag cag cac agc      912
 Leu Lys Thr Ser Pro Glu Leu Ala Glu Leu Leu Arg Gln Gln His Ser
     290                 295                 300

 gat gtg cgt cca agc cgc cat ctg aat aaa gcg cac tgg agc acc gtg      960
 Asp Val Arg Pro Ser Arg His Leu Asn Lys Ala His Trp Ser Thr Val
 305                 310                 315                 320

 tat ctc gac ggt tcg ctg cca gat tcg caa atc tat tat ctg gtg gat     1008
 Tyr Leu Asp Gly Ser Leu Pro Asp Ser Gln Ile Tyr Tyr Leu Val Asp
                 325                 330                 335

 gcg tct tat cag cag gcg gtg aat tta ctg ccg gaa gaa aaa cat atg     1056
 Ala Ser Tyr Gln Gln Ala Val Asn Leu Leu Pro Glu Glu Lys His Met
             340                 345                 350

 aaa ctg tgg gta acg cac agc cag ttt att gtt gag cat att aat gcc     1104
 Lys Leu Trp Val Thr His Ser Gln Phe Ile Val Glu His Ile Asn Ala
         355                 360                 365

 atg acc acg ctg gcg cgg gaa cac cgg gca ttg cca cct gaa ctg gca     1152
 Met Thr Thr Leu Ala Arg Glu His Arg Ala Leu Pro Pro Glu Leu Ala
     370                 375                 380

 caa gag tat tta cag tct tgt gaa atc gcc att cag cgt tgt cag cag     1200
 Gln Glu Tyr Leu Gln Ser Cys Glu Ile Ala Ile Gln Arg Cys Gln Gln
 385                 390                 395                 400

 cga ctg gag tat gac gaa ccg ggt agt tct ggc gat gcc aat atc atg     1248
 Arg Leu Glu Tyr Asp Glu Pro Gly Ser Ser Gly Asp Ala Asn Ile Met
                 405                 410                 415

 gat gcg ccg gag atg cag ccg cac gaa ggc gcg gca ggt acg ctg gag     1296
 Asp Ala Pro Glu Met Gln Pro His Glu Gly Ala Ala Gly Thr Leu Glu
             420                 425                 430

 cag cat tta cag cgg gtt att ggt cat ctg aac acc atg cac acc att     1344
 Gln His Leu Gln Arg Val Ile Gly His Leu Asn Thr Met His Thr Ile
         435                 440                 445

 tcg tcg atg gca tgg cgt cat cag gat cca cac gcg ggc gat gcg gct     1392
 Ser Ser Met Ala Trp Arg His Gln Asp Pro His Ala Gly Asp Ala Ala
     450                 455                 460

 gaa atg cca gta gca gaa ttg ccc aac cgg att atc cgg atg ctg gcg     1440
 Glu Met Pro Val Ala Glu Leu Pro Asn Arg Ile Ile Arg Met Leu Ala
 465                 470                 475                 480

 ggc gat ttt ttc cag tgc gcc aat ttg ctt ttc cat cgt aaa acg cgt     1488
 Gly Asp Phe Phe Gln Cys Ala Asn Leu Leu Phe His Arg Lys Thr Arg
                 485                 490                 495

 tgg cag gcg atg gta aag aat gtc atc agc cag cac gcg cag gcg agc     1536
 Trp Gln Ala Met Val Lys Asn Val Ile Ser Gln His Ala Gln Ala Ser
             500                 505                 510

 ggc gac ggt ttg cgc att cca gcg gat aac ttc ttc cgc atg gct acg     1584
 Gly Asp Gly Leu Arg Ile Pro Ala Asp Asn Phe Phe Arg Met Ala Thr
         515                 520                 525

 ctc gac cag ctt ttg cac ctc ttc cgg ctg atg caa act gac cga aat     1632
 Leu Asp Gln Leu Leu His Leu Phe Arg Leu Met Gln Thr Asp Arg Asn
     530                 535                 540

 atg ttc ctg gtt acc cac cgc cac gcc gcc acc att ctc acc gga caa     1680
 Met Phe Leu Val Thr His Arg His Ala Ala Thr Ile Leu Thr Gly Gln
 545                 550                 555                 560

 tac tcc atc cac cac ggc att ctg atg ccg cca atg tac ggg caa ccg     1728
 Tyr Ser Ile His His Gly Ile Leu Met Pro Pro Met Tyr Gly Gln Pro
                 565                 570                 575

 ggc ggg ctg caa ggg tta acc acg ctg ccg cag ttg ctg cac gat cag     1776
 Gly Gly Leu Gln Gly Leu Thr Thr Leu Pro Gln Leu Leu His Asp Gln
             580                 585                 590

 ggc tac gtc act cag gcc atc gga aaa tgg cat atg ggg gaa aac aaa     1824
 Gly Tyr Val Thr Gln Ala Ile Gly Lys Trp His Met Gly Glu Asn Lys
         595                 600                 605

 gag tcg cag ccg cag aac gtt ggc ttt gat gat ttc cgt ggc ttt aac     1872
 Glu Ser Gln Pro Gln Asn Val Gly Phe Asp Asp Phe Arg Gly Phe Asn
     610                 615                 620

 tcg gtg tct gat atg tac acc gaa tgg cgc gac gtt cac gtc aat ccg     1920
 Ser Val Ser Asp Met Tyr Thr Glu Trp Arg Asp Val His Val Asn Pro
 625                 630                 635                 640

 gaa gtg gcc ctg agt ccg gac cgt tct gaa tac atc aag caa tta ccg     1968
 Glu Val Ala Leu Ser Pro Asp Arg Ser Glu Tyr Ile Lys Gln Leu Pro
                 645                 650                 655

 ttc agc aaa gat gac gtt cat gcg gtg cgc ggc ggc gaa caa cag gcc     2016
 Phe Ser Lys Asp Asp Val His Ala Val Arg Gly Gly Glu Gln Gln Ala
             660                 665                 670

 att gcc gac att acg ccg aac ttt aaa cta aaa agc aag atg ggg gag     2064
 Ile Ala Asp Ile Thr Pro Asn Phe Lys Leu Lys Ser Lys Met Gly Glu
         675                 680                 685

 gag ttt ttc ttt caa acc acc gat cgg cag tac ctg acc acg cag agt     2112
 Glu Phe Phe Phe Gln Thr Thr Asp Arg Gln Tyr Leu Thr Thr Gln Ser
     690                 695                 700

 gat ctc acc ggt cat tgc cac atc ggc acg aac cgg gtt acc ggt cag     2160
 Asp Leu Thr Gly His Cys His Ile Gly Thr Asn Arg Val Thr Gly Gln
 705                 710                 715                 720

 gca aga aac cag cgc ggt gca cat agc aat acc ggc act cgg acc atc     2208
 Ala Arg Asn Gln Arg Gly Ala His Ser Asn Thr Gly Thr Arg Thr Ile
                 725                 730                 735

 ttt cgg cgt cgc acc ttc cgg tac gtg gac gtg gat gtc acg ttt ttc     2256
 Phe Arg Arg Arg Thr Phe Arg Tyr Val Asp Val Asp Val Thr Phe Phe
             740                 745                 750

 ttt gcc ttt acc cgg aac aca tgc ggt ttc aat ggt cag caa gtc acc     2304
 Phe Ala Phe Thr Arg Asn Thr Cys Gly Phe Asn Gly Gln Gln Val Thr
         755                 760                 765

 gcc cac ttc cgt cca cgc cag acc ggt tac ctg acc gac acg gtt ttc     2352
 Ala His Phe Arg Pro Arg Gln Thr Gly Tyr Leu Thr Asp Thr Val Phe
     770                 775                 780

 gtt atc cgc gcg acc ata gtc gaa acg ctg aac acc gag ata gtc atg     2400
 Val Ile Arg Ala Thr Ile Val Glu Thr Leu Asn Thr Glu Ile Val Met
 785                 790                 795                 800

 cag ttt gga gat ttc acg ctc cag acc acg cac gcc cgc ctc acg ggt     2448
 Gln Phe Gly Asp Phe Thr Leu Gln Thr Thr His Ala Arg Leu Thr Gly
                 805                 810                 815

 gta gta acg aat aat gcc gat aat ggc gct atc gtc gac ggt cag ctc     2496
 Val Val Thr Asn Asn Ala Asp Asn Gly Ala Ile Val Asp Gly Gln Leu
             820                 825                 830

 acc ttt ttt cag tgc att acg ttc aat ctg ctt cgg cag cag gtg atg     2544
 Thr Phe Phe Gln Cys Ile Thr Phe Asn Leu Leu Arg Gln Gln Val Met
         835                 840                 845

 ttt gtc gcg acg tcg act cgc gtt gcc ggg cgt cac gat atg gac agc     2592
 Phe Val Ala Thr Ser Thr Arg Val Ala Gly Arg His Asp Met Asp Ser
     850                 855                 860

 ctc gcg gaa cgt tgg ttg aag cac aaa acc atc act ttt gaa gag att     2640
 Leu Ala Glu Arg Trp Leu Lys His Lys Thr Ile Thr Phe Glu Glu Ile
 865                 870                 875                 880

 gct ggt aaa ggc aaa aat caa ctg acc ttt aac cag att gcc ctc gaa     2688
 Ala Gly Lys Gly Lys Asn Gln Leu Thr Phe Asn Gln Ile Ala Leu Glu
                 885                 890                 895

 gaa gcc gga cgt tac gcc gcc gaa gat gca gat ctc atc cgg cac ttc     2736
 Glu Ala Gly Arg Tyr Ala Ala Glu Asp Ala Asp Leu Ile Arg His Phe
             900                 905                 910

 gtt ata cga cag cac atg cag ccc cgg cgc aaa caa cct tgc ata acg     2784
 Val Ile Arg Gln His Met Gln Pro Arg Arg Lys Gln Pro Cys Ile Thr
         915                 920                 925

 cgc cag caa agg gcg cag ctg cgg tgg cac cag cag cac cgg gtc ttt     2832
 Arg Gln Gln Arg Ala Gln Leu Arg Trp His Gln Gln His Arg Val Phe
     930                 935                 940

 ccc cgc cgc ttt cat ctg ctc ttt cac ctg tgg cat cgt act ctg gaa     2880
 Pro Arg Arg Phe His Leu Leu Phe His Leu Trp His Arg Thr Leu Glu
 945                 950                 955                 960

 ctg gtt gcc aga tat ttt tca atc cag caa gcg atg ggt gat ggt gaa     2928
 Leu Val Ala Arg Tyr Phe Ser Ile Gln Gln Ala Met Gly Asp Gly Glu
                 965                 970                 975

 aag tct ata gtc ggc aat gca gat ata gaa acg tgc tca tcg ttt tat     2976
 Lys Ser Ile Val Gly Asn Ala Asp Ile Glu Thr Cys Ser Ser Phe Tyr
             980                 985                 990

 ttc tcc ggc gag gcg gaa agt gtc cca gcg gtg tcg caa ggc gag atc     3024
 Phe Ser Gly Glu Ala Glu Ser Val Pro Ala Val Ser Gln Gly Glu Ile
         995                1000                1005

 tcg tat ccg gca ttc gtt cga tca aca ctg ggc ttg ggc ccg acg gac     3072
 Ser Tyr Pro Ala Phe Val Arg Ser Thr Leu Gly Leu Gly Pro Thr Asp
    1010                1015                1020

 act ggt ccg gta tct gct tct cgc gtc tat cgc caa gtt aat atc aag     3120
 Thr Gly Pro Val Ser Ala Ser Arg Val Tyr Arg Gln Val Asn Ile Lys
1025                1030                1035                1040

 caa agg tac tgg ggt att ttc ggc ggt gca att gcc gac cgc ttt ggt     3168
 Gln Arg Tyr Trp Gly Ile Phe Gly Gly Ala Ile Ala Asp Arg Phe Gly
                1045                1050                1055

 gcc aaa ccg atg att gtt acc ggt atg ctg atg cgc gcc gcc gga ttc     3216
 Ala Lys Pro Met Ile Val Thr Gly Met Leu Met Arg Ala Ala Gly Phe
            1060                1065                1070

 gcc aca atg ggt atc gcc cac gaa ccg tgg cta ttg tgg ttt tca tgc     3264
 Ala Thr Met Gly Ile Ala His Glu Pro Trp Leu Leu Trp Phe Ser Cys
        1075                1080                1085

 ctg ctc tcg gga ctc ggt ggc acg ttg ttt gat ccg ccg cgt tcg gcg     3312
 Leu Leu Ser Gly Leu Gly Gly Thr Leu Phe Asp Pro Pro Arg Ser Ala
    1090                1095                1100

 ctg gtg gtg aaa tta atc cgt cca cag cag cgt ggt cgt ttt ttc tcg     3360
 Leu Val Val Lys Leu Ile Arg Pro Gln Gln Arg Gly Arg Phe Phe Ser
1105                1110                1115                1120

 ctg ttg atg atg cag gac agt gcc ggt gcg gtc att ggc gca ttg ttg     3408
 Leu Leu Met Met Gln Asp Ser Ala Gly Ala Val Ile Gly Ala Leu Leu
                1125                1130                1135

 ggg agc tgg ctg ttg caa tac gac ttt cgc ctg gtc tgc gcc aca ggg     3456
 Gly Ser Trp Leu Leu Gln Tyr Asp Phe Arg Leu Val Cys Ala Thr Gly
            1140                1145                1150

 gca gtt cta ttt gtg cta tgt gcg gcg ttc aat gcg tgg ttg tta cca     3504
 Ala Val Leu Phe Val Leu Cys Ala Ala Phe Asn Ala Trp Leu Leu Pro
        1155                1160                1165

 gca tgg aaa ctc tcc acc gta cgc acg ccc gtt cgc gaa ggc atg acc     3552
 Ala Trp Lys Leu Ser Thr Val Arg Thr Pro Val Arg Glu Gly Met Thr
    1170                1175                1180

 cgc gtg atg cgt gac aag cgt ttt gtc acc tat gtt ctg acg ctg gcg     3600
 Arg Val Met Arg Asp Lys Arg Phe Val Thr Tyr Val Leu Thr Leu Ala
1185                1190                1195                1200

 ggt tac tac atg ctg gct gta caa gtg atg ctg atg ctg cca att atg     3648
 Gly Tyr Tyr Met Leu Ala Val Gln Val Met Leu Met Leu Pro Ile Met
                1205                1210                1215

 gtc aac gac gtg gct ggc gcg ccc tct gcc gtt aaa tgg atg tat gcc     3696
 Val Asn Asp Val Ala Gly Ala Pro Ser Ala Val Lys Trp Met Tyr Ala
            1220                1225                1230

 aac cgg gag gca cca cca ttg aag cgg tac gcg tac tgg aag aga aag     3744
 Asn Arg Glu Ala Pro Pro Leu Lys Arg Tyr Ala Tyr Trp Lys Arg Lys
        1235                1240                1245

 gct tcc gtg ctg cag tga                                             3762
 Ala Ser Val Leu Gln 
    1250





      <210> 882
      <211> 318
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (1)..(318)

      <220>
      <221> misc_feature
      <222> (1)...(318)
      <223> n = a,t,c or g

      <400> 882
  atg gcg ttg gct att ggt agt ggt gtg gca ccc cag tac ggt tta tat      48
  Met Ala Leu Ala Ile Gly Ser Gly Val Ala Pro Gln Tyr Gly Leu Tyr
    1               5                  10                  15

 acc gca gct gtt gcg ggg att gtc att gct ctg acg ggt ggg tca cgc       96
 Thr Ala Ala Val Ala Gly Ile Val Ile Ala Leu Thr Gly Gly Ser Arg
              20                  25                  30

 ttt agc gtt tcc ggt ccg act gcg gca ttt gtg gta att ctc tat ccc      144
 Phe Ser Val Ser Gly Pro Thr Ala Ala Phe Val Val Ile Leu Tyr Pro
          35                  40                  45

 gtg tcg caa cag ttt gga ctt gca gga ctg ctt gtt gcg acc ttg ctt      192
 Val Ser Gln Gln Phe Gly Leu Ala Gly Leu Leu Val Ala Thr Leu Leu
      50                  55                  60

 gtc gng atc ttt ttg att ctg atg ggt ctg gca cgc ttt ggt cgc ctg      240
 Val XXX Ile Phe Leu Ile Leu Met Gly Leu Ala Arg Phe Gly Arg Leu
  65                  70                  75                  80

 att gag tat att ncg ggt tcc gtc acc tta agt ttc acc tcc ggt atc      288
 Ile Glu Tyr Ile XXX Gly Ser Val Thr Leu Ser Phe Thr Ser Gly Ile
                  85                  90                  95

 ggg gat cac caa tcg gac cat gca gaa taa                              318
 Gly Asp His Gln Ser Asp His Ala Glu 
             100                 105





      <210> 883
      <211> 546
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (1)..(546)

      <400> 883
  atg acc ttt gtc ggc tca atg agc ggc gca ctg ctg gtg caa tac gtt      48
  Met Thr Phe Val Gly Ser Met Ser Gly Ala Leu Leu Val Gln Tyr Val
    1               5                  10                  15

 cag gct gat gtc tta cgg cag att ttg ccc att ctg gta att tgt atc       96
 Gln Ala Asp Val Leu Arg Gln Ile Leu Pro Ile Leu Val Ile Cys Ile
              20                  25                  30

 ggc ctc tat ttc ttg ctg atg cca aag cta ggt gaa gaa gac cgc cag      144
 Gly Leu Tyr Phe Leu Leu Met Pro Lys Leu Gly Glu Glu Asp Arg Gln
          35                  40                  45

 cgc cgg atg tac ggt tta ccc ttc gcg tta ata gcc ggt ggc tgc gtc      192
 Arg Arg Met Tyr Gly Leu Pro Phe Ala Leu Ile Ala Gly Gly Cys Val
      50                  55                  60

 ggt ttt tat gat gga ttc ttt ggc ccg gct gcc ggg tcg ttt tac gcg      240
 Gly Phe Tyr Asp Gly Phe Phe Gly Pro Ala Ala Gly Ser Phe Tyr Ala
  65                  70                  75                  80

 ctg gcc ttc gtt acg ctg tgc gga ttt aac ctc gcc aaa gcc acg gct      288
 Leu Ala Phe Val Thr Leu Cys Gly Phe Asn Leu Ala Lys Ala Thr Ala
                  85                  90                  95

 cac gcc aaa tta ctc aac gca acg tca aac atc ggc ggt tta ctg ctg      336
 His Ala Lys Leu Leu Asn Ala Thr Ser Asn Ile Gly Gly Leu Leu Leu
             100                 105                 110

 ttt att ctc ggc ggc aaa gtg att tgg gcg acg ggc ttt gtc atg ctg      384
 Phe Ile Leu Gly Gly Lys Val Ile Trp Ala Thr Gly Phe Val Met Leu
         115                 120                 125

 gtg ggg cag ttc ctc ggc gcg cgc atg ggt tca cga ctg gtg ttg agc      432
 Val Gly Gln Phe Leu Gly Ala Arg Met Gly Ser Arg Leu Val Leu Ser
     130                 135                 140

 aaa gga caa aag ctg atc cgc ccg atg att gtt atc gtc tcg gcg gtg      480
 Lys Gly Gln Lys Leu Ile Arg Pro Met Ile Val Ile Val Ser Ala Val
 145                 150                 155                 160

 atg agt gcc aaa tta ctt tac gac agc cac gga cag gag atc ctc cac      528
 Met Ser Ala Lys Leu Leu Tyr Asp Ser His Gly Gln Glu Ile Leu His
                 165                 170                 175

 tgg ttg ggg atg aac taa                                              546
 Trp Leu Gly Met Asn 
             180





      <210> 884
      <211> 666
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (357)..(666)

      <400> 884
 atggggctat gcagacctga tgtcagccca gacacaggac tgcaggtggg ggccactcat     60

 ccatccgagg aacgggagct ggagccaccc caagtcacgg ggctcagccc agggcttctg    120

 gaccccgaag gccgtgatga agatgttgac taccacgatg atgaacacca ggcccgtggc    180

 caggttgttg aggaagtcca gcttggcgtg cttggccggg ttgttaaggt cgtacttgac    240

 taaagccttc agaagcagcc agtccctggc ctcctccacc tcggagaggc ttgcaggcag    300

 gtatgccgtt tccacatcac caagggagaa agcgagtctg gcaaggtggc gcagca        356                                                                 
 tgc ccg aga gaa gca atg tgt cca ggc tgc aca gcg agg cac agc tgg      404
 Met Leu Arg His Leu Ala Arg Leu Ala Phe Ser Leu Gly Asp Val Glu
   1               5                  10                  15

 ccc tag aag gcc aca gaa caa cag aaa caa agt gga cgt cca cca caa      452
 Thr Ala Tyr Leu Pro Ala Ser Leu Ser Glu Val Glu Glu Ala Arg Asp
              20                  25                  30

 ggg agt ggc taa gtg gat tat ggc cat ctg cat tcg gga gtg gga tgc      500
 Trp Leu Leu Leu Lys Ala Leu Val Lys Tyr Asp Leu Asn Asn Pro Ala
          35                  40                  45

 cat cgt cta cag agc aag cga ggc cag gcc agc gga tgt gga ggg gtc      548
 Lys His Ala Lys Leu Asp Phe Leu Asn Asn Leu Ala Thr Gly Leu Val
      50                  55                  60

 cag ctg cac tgc ggg cag aga aca ggc agg agc agg agg ctg gcc cct      596
 Phe Ile Ile Val Val Val Asn Ile Phe Ile Thr Ala Phe Gly Val Gln
  65                  70                  75                  80

 gct tcc tct gct gca ccc tga cac act gct ctg ttc ctt cct tta cgg      644
 Lys Pro Trp Ala Glu Pro Arg Asp Leu Gly Trp Leu Gln Leu Pro Phe
                  85                  90                  95

 aga tgg cgg agc cca ggt ttg a                                        666
 Leu Gly Trp Met Ser Gly Pro His Leu Gln Ser Cys Val Trp Ala Asp 
             100                 105                 110





      <210> 885
      <211> 4539
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (1)..(4539)

      <400> 885
  atg cgg ggg gcg ccc gcg cgc ctg ctg ctg ccg ctg ctg ccg tgg ctc      48
  Met Arg Gly Ala Pro Ala Arg Leu Leu Leu Pro Leu Leu Pro Trp Leu
    1               5                  10                  15

 ctg ctg ctc ctg gcg ccc gag gct cgg ggc gcg ccc ggc tgc ccg cta       96
 Leu Leu Leu Leu Ala Pro Glu Ala Arg Gly Ala Pro Gly Cys Pro Leu
              20                  25                  30

 tcc atc cgc agc tgc aag tgc tcg ggg gag cgg ccc aag ggg ctg agc      144
 Ser Ile Arg Ser Cys Lys Cys Ser Gly Glu Arg Pro Lys Gly Leu Ser
          35                  40                  45

 ggc ggc gtc cct ggc ccg gct cgg cgg agg gtg gtg tgc agc ggc ggg      192
 Gly Gly Val Pro Gly Pro Ala Arg Arg Arg Val Val Cys Ser Gly Gly
      50                  55                  60

 gac ctc ccg gag cct ccc gag ccc ggc ctt ctg cct aac ggc acc gtt      240
 Asp Leu Pro Glu Pro Pro Glu Pro Gly Leu Leu Pro Asn Gly Thr Val
  65                  70                  75                  80

 acc ctt ggc aac cgt ttc tcc act gcc cct tgc ccg cag tcg ggg ctg      288
 Thr Leu Gly Asn Arg Phe Ser Thr Ala Pro Cys Pro Gln Ser Gly Leu
                  85                  90                  95

 gcc cag tct ttt cga ttg tgt cca gaa caa tac agt aac gcc tct ggt      336
 Ala Gln Ser Phe Arg Leu Cys Pro Glu Gln Tyr Ser Asn Ala Ser Gly
             100                 105                 110

 tgg gtg agt tca gag gct gcc cgc ttc ctg aca gga cac aac tgg tca      384
 Trp Val Ser Ser Glu Ala Ala Arg Phe Leu Thr Gly His Asn Trp Ser
         115                 120                 125

 gcc tct gac gct ggc cgc ccg gcc tgc att ttc ccc ggc ccg gtc tcc      432
 Ala Ser Asp Ala Gly Arg Pro Ala Cys Ile Phe Pro Gly Pro Val Ser
     130                 135                 140

 tgg aga cag gta cca gct tac aac gcc gga cag gat cag ggt agc aaa      480
 Trp Arg Gln Val Pro Ala Tyr Asn Ala Gly Gln Asp Gln Gly Ser Lys
 145                 150                 155                 160

 tat agc ttc tat gga gga aag gtc aaa gat gag tat ctg cgt agg tcc      528
 Tyr Ser Phe Tyr Gly Gly Lys Val Lys Asp Glu Tyr Leu Arg Arg Ser
                 165                 170                 175

 ccg atc tgt cgc tct gct gcc gcc ctg cac act gac acc agt gcc cgc      576
 Pro Ile Cys Arg Ser Ala Ala Ala Leu His Thr Asp Thr Ser Ala Arg
             180                 185                 190

 agc tgg tct gaa ttt agg ctc ttg agc aat aac aag atc acg ggg ctc      624
 Ser Trp Ser Glu Phe Arg Leu Leu Ser Asn Asn Lys Ile Thr Gly Leu
         195                 200                 205

 cgc aat ggc tcc ttc ctg gga ctg tca ctg ctg gag aag ctt ctc atg      672
 Arg Asn Gly Ser Phe Leu Gly Leu Ser Leu Leu Glu Lys Leu Leu Met
     210                 215                 220

 aga gca cat ttt tct gat gaa gat gaa aag acg gcc tgt cct tct cca      720
 Arg Ala His Phe Ser Asp Glu Asp Glu Lys Thr Ala Cys Pro Ser Pro
 225                 230                 235                 240

 gca cca agg ctc tgg agg ctg cat agc aag tgc acc ctg agc atg gca      768
 Ala Pro Arg Leu Trp Arg Leu His Ser Lys Cys Thr Leu Ser Met Ala
                 245                 250                 255

 ggc aat cag aag aac cag ggc ggc agc agc tca caa gag gca gca tct      816
 Gly Asn Gln Lys Asn Gln Gly Gly Ser Ser Ser Gln Glu Ala Ala Ser
             260                 265                 270

 ggc ttg atg ccg agt cgg cgg ctc cag cgg gga gag gtt gag ggc ctc      864
 Gly Leu Met Pro Ser Arg Arg Leu Gln Arg Gly Glu Val Glu Gly Leu
         275                 280                 285

 tgc act tgc ctc tgc acg gac ctg agg aac aac atc atc agc aca gtg      912
 Cys Thr Cys Leu Cys Thr Asp Leu Arg Asn Asn Ile Ile Ser Thr Val
     290                 295                 300

 cag ccg ggc gcc ttc ctg ggc ctg ggg gag ctg aag cgt tta gat ctc      960
 Gln Pro Gly Ala Phe Leu Gly Leu Gly Glu Leu Lys Arg Leu Asp Leu
 305                 310                 315                 320

 tcc aac aac cgg att ggc tgt ctc acc tcc gag acc ttc cag ggc ctc     1008
 Ser Asn Asn Arg Ile Gly Cys Leu Thr Ser Glu Thr Phe Gln Gly Leu
                 325                 330                 335

 ccc agg ctt ctc cga cta aac ata tct gga aac atc ttc tcc agt ctg     1056
 Pro Arg Leu Leu Arg Leu Asn Ile Ser Gly Asn Ile Phe Ser Ser Leu
             340                 345                 350

 caa cct ggg gtc ttt gat gag ctg cca gcc ctt aag gtt gtg gac ttg     1104
 Gln Pro Gly Val Phe Asp Glu Leu Pro Ala Leu Lys Val Val Asp Leu
         355                 360                 365

 ggc acc gag ttc ctg acc tgt gac tgc cac ctg cgc tgg ctg ctg ccc     1152
 Gly Thr Glu Phe Leu Thr Cys Asp Cys His Leu Arg Trp Leu Leu Pro
     370                 375                 380

 tgg gcc cag aat cgc tcc ctg cag ctg tcg gaa cac acg ctc tgt gct     1200
 Trp Ala Gln Asn Arg Ser Leu Gln Leu Ser Glu His Thr Leu Cys Ala
 385                 390                 395                 400

 tac ccc agt gcc ctg cat gct cat gcc ctg ggc agc ctc cag gag gcc     1248
 Tyr Pro Ser Ala Leu His Ala His Ala Leu Gly Ser Leu Gln Glu Ala
                 405                 410                 415

 cag ctc tgc tgc gag ggg gcc ctg gag ctg cac aca cac cac ctc atc     1296
 Gln Leu Cys Cys Glu Gly Ala Leu Glu Leu His Thr His His Leu Ile
             420                 425                 430

 ccg tcc cta cgc caa gtg gtg ttc cag ggg gat cgg ctg ccc ttc cag     1344
 Pro Ser Leu Arg Gln Val Val Phe Gln Gly Asp Arg Leu Pro Phe Gln
         435                 440                 445

 tgc tct gcc agc tac ctg ggc aac gac acc cgc atc cgc tgg tac cac     1392
 Cys Ser Ala Ser Tyr Leu Gly Asn Asp Thr Arg Ile Arg Trp Tyr His
     450                 455                 460

 aac cga gcc cct gtg gag ggt gat gag cag gcg ggc atc ctc ctg gcc     1440
 Asn Arg Ala Pro Val Glu Gly Asp Glu Gln Ala Gly Ile Leu Leu Ala
 465                 470                 475                 480

 gag agc ctc atc cac gac tgc acc ttc atc acc agt gag ctg acg ctg     1488
 Glu Ser Leu Ile His Asp Cys Thr Phe Ile Thr Ser Glu Leu Thr Leu
                 485                 490                 495

 tct cac atc ggc gtg tgg gcc tca ggc gag tgg gag tgc acc gtg tcc     1536
 Ser His Ile Gly Val Trp Ala Ser Gly Glu Trp Glu Cys Thr Val Ser
             500                 505                 510

 atg gcc caa ggc aac gcc agc aag aag gtg gag atc gtg gtg ctg gag     1584
 Met Ala Gln Gly Asn Ala Ser Lys Lys Val Glu Ile Val Val Leu Glu
         515                 520                 525

 acc tct gcc tcc tac tgc ccc gcc gag cgt gtt gcc aac aac cgc ggg     1632
 Thr Ser Ala Ser Tyr Cys Pro Ala Glu Arg Val Ala Asn Asn Arg Gly
     530                 535                 540

 gac ttc agg tgg ccc cga act ctg gct ggc atc aca gcc tac cag tcc     1680
 Asp Phe Arg Trp Pro Arg Thr Leu Ala Gly Ile Thr Ala Tyr Gln Ser
 545                 550                 555                 560

 tgc ctg cag tat ccc ttc acc tca gtg ccc ctg ggc ggg ggt gcc ccg     1728
 Cys Leu Gln Tyr Pro Phe Thr Ser Val Pro Leu Gly Gly Gly Ala Pro
                 565                 570                 575

 ggc acc cga gcc tcc cgc cgg tgt gac cgt gcc ggc cgc tgg gag cca     1776
 Gly Thr Arg Ala Ser Arg Arg Cys Asp Arg Ala Gly Arg Trp Glu Pro
             580                 585                 590

 ggg gac tac tcc cac tgt ctc tac acc aac gac atc acc agg gtg ctg     1824
 Gly Asp Tyr Ser His Cys Leu Tyr Thr Asn Asp Ile Thr Arg Val Leu
         595                 600                 605

 tac acc ttc gtg ctg atg ccc atc aat gcc tcc aat gcg ctg acc ctg     1872
 Tyr Thr Phe Val Leu Met Pro Ile Asn Ala Ser Asn Ala Leu Thr Leu
     610                 615                 620

 gct cac cag ctg cgc gtg tac aca gcc gag gcc gct agc ttt tca gac     1920
 Ala His Gln Leu Arg Val Tyr Thr Ala Glu Ala Ala Ser Phe Ser Asp
 625                 630                 635                 640

 atg atg gat gta gtc tat gtg gct cag atg atc cag aaa ttt ttg ggt     1968
 Met Met Asp Val Val Tyr Val Ala Gln Met Ile Gln Lys Phe Leu Gly
                 645                 650                 655

 tat gtc gac cag atc aaa gag ctg gta gag gtg atg gtg gac atg ccc     2016
 Tyr Val Asp Gln Ile Lys Glu Leu Val Glu Val Met Val Asp Met Pro
             660                 665                 670

 agc aac ttg atg ctg gtg gac gag cac ctg ctg tgg ctg gcc cag cgc     2064
 Ser Asn Leu Met Leu Val Asp Glu His Leu Leu Trp Leu Ala Gln Arg
         675                 680                 685

 gag gac aag gcc tgc agc cgc atc gtg ggt gcc ata gag cgc att ggg     2112
 Glu Asp Lys Ala Cys Ser Arg Ile Val Gly Ala Ile Glu Arg Ile Gly
     690                 695                 700

 ggg gcc gcc ctc agc ccc cat gcc cag cac atc tca gtg aat gcg agg     2160
 Gly Ala Ala Leu Ser Pro His Ala Gln His Ile Ser Val Asn Ala Arg
 705                 710                 715                 720

 aac gtg gca ttg gag gcc tac ctc atc aag ccg cac agc tac gtg ggc     2208
 Asn Val Ala Leu Glu Ala Tyr Leu Ile Lys Pro His Ser Tyr Val Gly
                 725                 730                 735

 ctg acc tgc aca gcc ttc cag agg agg gag gga ggg gtg ccg ggc aca     2256
 Leu Thr Cys Thr Ala Phe Gln Arg Arg Glu Gly Gly Val Pro Gly Thr
             740                 745                 750

 cgg cca gga agc cct ggc cag aac ccc cca cct gag ccc gag ccc cca     2304
 Arg Pro Gly Ser Pro Gly Gln Asn Pro Pro Pro Glu Pro Glu Pro Pro
         755                 760                 765

 gct gac cag cag ctc cgc ttc cgc tgc acc acc ggg agg ccc aat gtt     2352
 Ala Asp Gln Gln Leu Arg Phe Arg Cys Thr Thr Gly Arg Pro Asn Val
     770                 775                 780

 tct ctg tcg tcc ttc cac atc aag aac agc gtg gcc ctg gcc tcc atc     2400
 Ser Leu Ser Ser Phe His Ile Lys Asn Ser Val Ala Leu Ala Ser Ile
 785                 790                 795                 800

 cag ctg ccc ccg agt cta ttc tca tcc ctt ccg gct gcc ctg gct ccc     2448
 Gln Leu Pro Pro Ser Leu Phe Ser Ser Leu Pro Ala Ala Leu Ala Pro
                 805                 810                 815

 ccg gtg ccc cca gac tgc acc ctg caa ctg ctc gtc ttc cga aat ggc     2496
 Pro Val Pro Pro Asp Cys Thr Leu Gln Leu Leu Val Phe Arg Asn Gly
             820                 825                 830

 cgc ctc ttc cac agc cac agc aac acc tcc cgc cct gga gct gct ggg     2544
 Arg Leu Phe His Ser His Ser Asn Thr Ser Arg Pro Gly Ala Ala Gly
         835                 840                 845

 cct ggc aag agg cgt ggc gtg gcc acc ccc gtc atc ttc gca gga acc     2592
 Pro Gly Lys Arg Arg Gly Val Ala Thr Pro Val Ile Phe Ala Gly Thr
     850                 855                 860

 agt ggc tgt ggc gtg gga aac ctg aca gag cca gtg gcc gtt tcg ctg     2640
 Ser Gly Cys Gly Val Gly Asn Leu Thr Glu Pro Val Ala Val Ser Leu
 865                 870                 875                 880

 cgg cac tgg gct gag gga gcc gaa cct gtg gcc gct tgg tgg agc cag     2688
 Arg His Trp Ala Glu Gly Ala Glu Pro Val Ala Ala Trp Trp Ser Gln
                 885                 890                 895

 gag ggg ccc ggg gag gct ggg ggc tgg acc tcg gag ggc tgc cag ctc     2736
 Glu Gly Pro Gly Glu Ala Gly Gly Trp Thr Ser Glu Gly Cys Gln Leu
             900                 905                 910

 cgc tcc agc cag ccc aat gtc agc gcc ctg cac tgc cag cac ttg ggc     2784
 Arg Ser Ser Gln Pro Asn Val Ser Ala Leu His Cys Gln His Leu Gly
         915                 920                 925

 aat gtg gcc gtg ctc atg gag ctg agc gcc ttt ccc agg gag ttg ggg     2832
 Asn Val Ala Val Leu Met Glu Leu Ser Ala Phe Pro Arg Glu Leu Gly
     930                 935                 940

 ggc gcc ggg gcc agc tcc atc cgt gtg tcc cgg aaa ggc tgg cac atg     2880
 Gly Ala Gly Ala Ser Ser Ile Arg Val Ser Arg Lys Gly Trp His Met
 945                 950                 955                 960

 ctg ctg aac ttg tgc ttc cac ata gcc atg acc tct gct gtc ttt gcg     2928
 Leu Leu Asn Leu Cys Phe His Ile Ala Met Thr Ser Ala Val Phe Ala
                 965                 970                 975

 ggg ggc atc aca ctc acc aac tac cag atg gtc tgc cag gcg gtg ggc     2976
 Gly Gly Ile Thr Leu Thr Asn Tyr Gln Met Val Cys Gln Ala Val Gly
             980                 985                 990

 atc acc ctg cac tac tcc tcc cta tcc acg ctg ctc tgg atg ggc gtg     3024
 Ile Thr Leu His Tyr Ser Ser Leu Ser Thr Leu Leu Trp Met Gly Val
         995                1000                1005

 aag gcg cga gtg ctc cat aag gag ctc acc tgg agg gca ccc cct ccg     3072
 Lys Ala Arg Val Leu His Lys Glu Leu Thr Trp Arg Ala Pro Pro Pro
    1010                1015                1020

 caa gaa ggg gac ccc gct ctg cct act ccc agt cct atg ctc cgg tac     3120
 Gln Glu Gly Asp Pro Ala Leu Pro Thr Pro Ser Pro Met Leu Arg Tyr
1025                1030                1035                1040

 ata ctt tca att cca gct ttg caa ttg ggg agg gac tcc aac gca ggc     3168
 Ile Leu Ser Ile Pro Ala Leu Gln Leu Gly Arg Asp Ser Asn Ala Gly
                1045                1050                1055

 gta gga aac ctc cca agg ttc tat ttg atc gct gga ggg att cca ctc     3216
 Val Gly Asn Leu Pro Arg Phe Tyr Leu Ile Ala Gly Gly Ile Pro Leu
            1060                1065                1070

 att atc tgt ggc atc aca gct gca gtc aac atc cac aac tac cgg gac     3264
 Ile Ile Cys Gly Ile Thr Ala Ala Val Asn Ile His Asn Tyr Arg Asp
        1075                1080                1085

 cac agc ccc tac tgc tgg ctg gtg tgg cgt cca agc ctt ggc gcc ttc     3312
 His Ser Pro Tyr Cys Trp Leu Val Trp Arg Pro Ser Leu Gly Ala Phe
    1090                1095                1100

 tac atc cct gtg gct ttg att ctg ctc atc acc tgg atc tat ttc ctg     3360
 Tyr Ile Pro Val Ala Leu Ile Leu Leu Ile Thr Trp Ile Tyr Phe Leu
1105                1110                1115                1120

 tgc gcc ggg cta cgc tta cgg ggt cct ctg gca cag aac ccc aag gcg     3408
 Cys Ala Gly Leu Arg Leu Arg Gly Pro Leu Ala Gln Asn Pro Lys Ala
                1125                1130                1135

 ggc aac agc agg gcc tcc ctg gag gca ggg gag gag ctg agg ggt tcc     3456
 Gly Asn Ser Arg Ala Ser Leu Glu Ala Gly Glu Glu Leu Arg Gly Ser
            1140                1145                1150

 acc agg ctc agg ggc agc ggc ccc ctc ctg agt gac tca ggt tcc ctt     3504
 Thr Arg Leu Arg Gly Ser Gly Pro Leu Leu Ser Asp Ser Gly Ser Leu
        1155                1160                1165

 ctt gct act ggg agc gcg cga gtg ggg acg ccc ggg ccc ccg gag gat     3552
 Leu Ala Thr Gly Ser Ala Arg Val Gly Thr Pro Gly Pro Pro Glu Asp
    1170                1175                1180

 ggt gac agc ctc tat tct ccg gga gtc cag cta ggg gcg ctg gtg acc     3600
 Gly Asp Ser Leu Tyr Ser Pro Gly Val Gln Leu Gly Ala Leu Val Thr
1185                1190                1195                1200

 acg cac ttc ctg tac ttg gcc atg tgg gcc tgc ggg gct ctg gca gtg     3648
 Thr His Phe Leu Tyr Leu Ala Met Trp Ala Cys Gly Ala Leu Ala Val
                1205                1210                1215

 tcc cag cgc tgg ctg ccc cgg gtg gtg tgc agc tgc ttg tac ggg gtg     3696
 Ser Gln Arg Trp Leu Pro Arg Val Val Cys Ser Cys Leu Tyr Gly Val
            1220                1225                1230

 gca gcc tcc gcc ctg ggc ctc ttc gtc ttc act cac cac tgt gcc agg     3744
 Ala Ala Ser Ala Leu Gly Leu Phe Val Phe Thr His His Cys Ala Arg
        1235                1240                1245

 cgg agg gac gtg aga gcc tcg tgg cgc gcc tgc tgc ccc cct gcc tct     3792
 Arg Arg Asp Val Arg Ala Ser Trp Arg Ala Cys Cys Pro Pro Ala Ser
    1250                1255                1260

 ccc gcg gcc ccc cat gcc ccg ccc cgg gcc ctg ccc gcc gcc gca gag     3840
 Pro Ala Ala Pro His Ala Pro Pro Arg Ala Leu Pro Ala Ala Ala Glu
1265                1270                1275                1280

 gac ggt tcc ccg gtg ttc ggg gag ggg ccc ccc tcc ctc aag tcc tcc     3888
 Asp Gly Ser Pro Val Phe Gly Glu Gly Pro Pro Ser Leu Lys Ser Ser
                1285                1290                1295

 cca agc ggc agc agc ggc cat ccg ctg gct ctg ggc ccc tgc aag ctc     3936
 Pro Ser Gly Ser Ser Gly His Pro Leu Ala Leu Gly Pro Cys Lys Leu
            1300                1305                1310

 acc aac ctg cag ctg gcc cag agt cag gtg tgc gag gcg ggg gcg gcg     3984
 Thr Asn Leu Gln Leu Ala Gln Ser Gln Val Cys Glu Ala Gly Ala Ala
        1315                1320                1325

 gcc ggc ggg gaa gga gag ccg gag ccg gcg ggc acc cgg gga aac ctc     4032
 Ala Gly Gly Glu Gly Glu Pro Glu Pro Ala Gly Thr Arg Gly Asn Leu
    1330                1335                1340

 gcc cac cgc cac ccc aac aac gtg cac cac ggg cgt cgg gcg cac aag     4080
 Ala His Arg His Pro Asn Asn Val His His Gly Arg Arg Ala His Lys
1345                1350                1355                1360

 agc cgg gcc aag gga cac cgc gcg ggg gag gcc tgc ggc aag aac cgg     4128
 Ser Arg Ala Lys Gly His Arg Ala Gly Glu Ala Cys Gly Lys Asn Arg
                1365                1370                1375

 ctc aag gcc ctg cgc ggg ggc gcg gcg ggg gcg ctg gaa ctg ctg tcc     4176
 Leu Lys Ala Leu Arg Gly Gly Ala Ala Gly Ala Leu Glu Leu Leu Ser
            1380                1385                1390

 agc gag agc ggt agt ctg cac aac agc ccc acc gac agc tac ctg ggc     4224
 Ser Glu Ser Gly Ser Leu His Asn Ser Pro Thr Asp Ser Tyr Leu Gly
        1395                1400                1405

 agc agc cgc aac agc ccg ggc gcc ggc ctg cag ctg gaa ggg gga gcc     4272
 Ser Ser Arg Asn Ser Pro Gly Ala Gly Leu Gln Leu Glu Gly Gly Ala
    1410                1415                1420

 cat gct cac gcc ggc agc gac acc agc gcc gcg ccg ctt tct gag gcg     4320
 His Ala His Ala Gly Ser Asp Thr Ser Ala Ala Pro Leu Ser Glu Ala
1425                1430                1435                1440

 ggc cgg gca ggc cag cgc cgc agc gcc agc cgc gac agt ctc aag ggc     4368
 Gly Arg Ala Gly Gln Arg Arg Ser Ala Ser Arg Asp Ser Leu Lys Gly
                1445                1450                1455

 ggc ggc gcg ctg gag aag gag agc cat cgc cgc tcg tac ccg ctc aac     4416
 Gly Gly Ala Leu Glu Lys Glu Ser His Arg Arg Ser Tyr Pro Leu Asn
            1460                1465                1470

 gcc gcc agc cta aac ggc gcc ccc aag ggg ggc aag tac gac gac gtc     4464
 Ala Ala Ser Leu Asn Gly Ala Pro Lys Gly Gly Lys Tyr Asp Asp Val
        1475                1480                1485

 acc ctg atg ggc gcg gag gta gcc agc ggc ggc tgc atg aag acc gga     4512
 Thr Leu Met Gly Ala Glu Val Ala Ser Gly Gly Cys Met Lys Thr Gly
    1490                1495                1500

 ctc tgg aag agc gaa act acc gtc taa                                 4539
 Leu Trp Lys Ser Glu Thr Thr Val 
1505                1510





      <210> 886
      <211> 774
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (1)..(774)

      <400> 886
  atg gcg tcg aag ata ggt tcg aga cgg tgg atg ttg cag ctg atc atg      48
  Met Ala Ser Lys Ile Gly Ser Arg Arg Trp Met Leu Gln Leu Ile Met
    1               5                  10                  15

 cag ttg ggt tcg gtg ctg ctc aca cgc tgc ccc ttt tgg ggc tgc ttc       96
 Gln Leu Gly Ser Val Leu Leu Thr Arg Cys Pro Phe Trp Gly Cys Phe
              20                  25                  30

 agc cag ctc atg ctg tac gct gag agg gct gag gca cgc cgg aag ccc      144
 Ser Gln Leu Met Leu Tyr Ala Glu Arg Ala Glu Ala Arg Arg Lys Pro
          35                  40                  45

 gac atc cca gtg cct tac ctg tat ttc gac atg ggg gca gcc gtg ctg      192
 Asp Ile Pro Val Pro Tyr Leu Tyr Phe Asp Met Gly Ala Ala Val Leu
      50                  55                  60

 tgc gct agt ttc atg tcc ttt ggc gtg aag cgg cgc tgg ttc gcg ctg      240
 Cys Ala Ser Phe Met Ser Phe Gly Val Lys Arg Arg Trp Phe Ala Leu
  65                  70                  75                  80

 ggg gcc gca ctc caa ttg gcc att agc acc tac gcc gcc tac atc ggg      288
 Gly Ala Ala Leu Gln Leu Ala Ile Ser Thr Tyr Ala Ala Tyr Ile Gly
                  85                  90                  95

 ggc tac gtc cac tac ggg gac tgg ctg aag gtc cgt atg tac tcg cgc      336
 Gly Tyr Val His Tyr Gly Asp Trp Leu Lys Val Arg Met Tyr Ser Arg
             100                 105                 110

 aca gtt gcc atc atc ggc ggc ttt ctt gtg ttg gcc agc ggt gct ggg      384
 Thr Val Ala Ile Ile Gly Gly Phe Leu Val Leu Ala Ser Gly Ala Gly
         115                 120                 125

 gag ctg tac cgc cgg aaa cct cgc agc cgc tcc ctg cag tcc acc ggc      432
 Glu Leu Tyr Arg Arg Lys Pro Arg Ser Arg Ser Leu Gln Ser Thr Gly
     130                 135                 140

 cag gtg ttc ctg ggt atc tac ctc atc tgt gtg gcc tac tca ctg cag      480
 Gln Val Phe Leu Gly Ile Tyr Leu Ile Cys Val Ala Tyr Ser Leu Gln
 145                 150                 155                 160

 cac agc aag gag gac cgg ctg gcg tat ctg aac cat ctc cca gga ggg      528
 His Ser Lys Glu Asp Arg Leu Ala Tyr Leu Asn His Leu Pro Gly Gly
                 165                 170                 175

 gag ctg atg atc cag ctg ttc ttc gtg ctg tat ggc atc ctg gcc ctg      576
 Glu Leu Met Ile Gln Leu Phe Phe Val Leu Tyr Gly Ile Leu Ala Leu
             180                 185                 190

 gcc ttt ctg tca ggc tac tac gtg acc ctc gct gcc cag atc ctg gct      624
 Ala Phe Leu Ser Gly Tyr Tyr Val Thr Leu Ala Ala Gln Ile Leu Ala
         195                 200                 205

 gta ctg ctg ccc cct gtc atg ctg ctc att gat ggc aat gtt gct tac      672
 Val Leu Leu Pro Pro Val Met Leu Leu Ile Asp Gly Asn Val Ala Tyr
     210                 215                 220

 tgg cac aac acg cgg cgt gtt gag ttc tgg aac cag atg aag ctc ctt      720
 Trp His Asn Thr Arg Arg Val Glu Phe Trp Asn Gln Met Lys Leu Leu
 225                 230                 235                 240

 gga gag agt gtg ggc atc ttc gga act gct gtc atc ctg gcc act gat      768
 Gly Glu Ser Val Gly Ile Phe Gly Thr Ala Val Ile Leu Ala Thr Asp
                 245                 250                 255

 ggc tga                                                              774
 Gly 






      <210> 887
      <211> 1107
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (1)..(1107)

      <400> 887
  atg ccg tat att tcg gcg tcg atc att atc cag ctg ctg acg gtg gtt      48
  Met Pro Tyr Ile Ser Ala Ser Ile Ile Ile Gln Leu Leu Thr Val Val
    1               5                  10                  15

 cac cca acg ttg gca gaa att aag aaa gaa ggg gag tct ggt cgt cgt       96
 His Pro Thr Leu Ala Glu Ile Lys Lys Glu Gly Glu Ser Gly Arg Arg
              20                  25                  30

 aag atc agc cag tac acc cgc tac ggt act ctg gtg ctg gca ata ttc      144
 Lys Ile Ser Gln Tyr Thr Arg Tyr Gly Thr Leu Val Leu Ala Ile Phe
          35                  40                  45

 cag tcg atc ggt att gct acc ggt ctg ccg aat atg cct ggt atg caa      192
 Gln Ser Ile Gly Ile Ala Thr Gly Leu Pro Asn Met Pro Gly Met Gln
      50                  55                  60

 ggc ctg gtg att aac ccg ggc ttt gca ttc tac ttc acc gct gtt gta      240
 Gly Leu Val Ile Asn Pro Gly Phe Ala Phe Tyr Phe Thr Ala Val Val
  65                  70                  75                  80

 agt ctg gtc aca gga acc atg ttc ctg atg tgg ttg ggc gaa cag att      288
 Ser Leu Val Thr Gly Thr Met Phe Leu Met Trp Leu Gly Glu Gln Ile
                  85                  90                  95

 act gaa cga ggt atc ggc aac ggt att tca atc att atc ttc gcc ggt      336
 Thr Glu Arg Gly Ile Gly Asn Gly Ile Ser Ile Ile Ile Phe Ala Gly
             100                 105                 110

 att gtc gcg gga ctc ccg cca gcc att gcc cat act atc gag caa gcg      384
 Ile Val Ala Gly Leu Pro Pro Ala Ile Ala His Thr Ile Glu Gln Ala
         115                 120                 125

 cgt caa ggc gac ctg cac ttc ctc gtg ttg ctg ttg gtt gca gta tta      432
 Arg Gln Gly Asp Leu His Phe Leu Val Leu Leu Leu Val Ala Val Leu
     130                 135                 140

 gta ttt gca gtg acg ttc ttt gtt gta ttt gtt gag cgt ggt caa cgc      480
 Val Phe Ala Val Thr Phe Phe Val Val Phe Val Glu Arg Gly Gln Arg
 145                 150                 155                 160

 cgc att gtg gta aac tac gcg aaa cgt cag caa ggt cgt cgt gtc tat      528
 Arg Ile Val Val Asn Tyr Ala Lys Arg Gln Gln Gly Arg Arg Val Tyr
                 165                 170                 175

 gct gca cag agc aca cat tta ccg ctg aaa gtg aat atg gcg ggg cag      576
 Ala Ala Gln Ser Thr His Leu Pro Leu Lys Val Asn Met Ala Gly Gln
             180                 185                 190

 ggc acg cgc ggt acc agc ctg tgc cca acc gtc tgc gta acc atc acg      624
 Gly Thr Arg Gly Thr Ser Leu Cys Pro Thr Val Cys Val Thr Ile Thr
         195                 200                 205

 cgg acc gaa ggt cag ggt att atc tgc atg ttt aac ttc aac agc atc      672
 Arg Thr Glu Gly Gln Gly Ile Ile Cys Met Phe Asn Phe Asn Ser Ile
     210                 215                 220

 gtt gag agt acg agt cag ctc gcc gtt ttt acc ttt gat cgt aat aac      720
 Val Glu Ser Thr Ser Gln Leu Ala Val Phe Thr Phe Asp Arg Asn Asn
 225                 230                 235                 240

 ctg acc gtt gat ttt tac gtc aac gcc ggc agg aac aac gac cgg tgc      768
 Leu Thr Val Asp Phe Tyr Val Asn Ala Gly Arg Asn Asn Asp Arg Cys
                 245                 250                 255

 ttt agc aac acg aga cat ttt ttc ctc cga tta ggc tac gta gca gat      816
 Phe Ser Asn Thr Arg His Phe Phe Leu Arg Leu Gly Tyr Val Ala Asp
             260                 265                 270

 aat ttc gcc acc aag acc agc ctg gcg cgc tgc acg atc agt cat aac      864
 Asn Phe Ala Thr Lys Thr Ser Leu Ala Arg Cys Thr Ile Ser His Asn
         275                 280                 285

 acc ttt aga ggt aga aac aac tgc gat acc cag acc cgc cat aac ttt      912
 Thr Phe Arg Gly Arg Asn Asn Cys Asp Thr Gln Thr Arg His Asn Phe
     290                 295                 300

 cgg cag ctc atc ttt acg ttt ata gat gcg cag acc tgg gcg gct gac      960
 Arg Gln Leu Ile Phe Thr Phe Ile Asp Ala Gln Thr Trp Ala Ala Asp
 305                 310                 315                 320

 acg ctg aat gct ttc tac aac agc ttt gcc ctg gaa ata ctt cag agt     1008
 Thr Leu Asn Ala Phe Tyr Asn Ser Phe Ala Leu Glu Ile Leu Gln Ser
                 325                 330                 335

 aag ttc cag ttc agg ctt ggt gtc gcc ttc aac ttt aaa atc ttc aat     1056
 Lys Phe Gln Phe Arg Leu Gly Val Ala Phe Asn Phe Lys Ile Phe Asn
             340                 345                 350

 aaa aca tct tta cct ttt tat gtt ttg tca aga aat ctt cgg cca ccc     1104
 Lys Thr Ser Leu Pro Phe Tyr Val Leu Ser Arg Asn Leu Arg Pro Pro
         355                 360                 365

 taa                                                                 1107
 






      <210> 888
      <211> 702
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (1)..(702)

      <400> 888
  atg atc cgc tgc ggc ctg gcc tgc gag cgc tgc cgc tgg atc ctg ccc      48
  Met Ile Arg Cys Gly Leu Ala Cys Glu Arg Cys Arg Trp Ile Leu Pro
    1               5                  10                  15

 ctg ctc cta ctc agc gcc atc gcc ttc gac atc atc gcg ctg gcc ggc       96
 Leu Leu Leu Leu Ser Ala Ile Ala Phe Asp Ile Ile Ala Leu Ala Gly
              20                  25                  30

 cgc ggc tgg ttg cag tct agc gac cac ggc cag acg tcc tcg ctg tgg      144
 Arg Gly Trp Leu Gln Ser Ser Asp His Gly Gln Thr Ser Ser Leu Trp
          35                  40                  45

 tgg aaa tgc tcc caa gag ggc ggc ggc agc ggg tcc tac gag gag ggc      192
 Trp Lys Cys Ser Gln Glu Gly Gly Gly Ser Gly Ser Tyr Glu Glu Gly
      50                  55                  60

 tgt cag agc ctc atg gag tac gat ttt tgc tgc tct aag tgt cgc aaa      240
 Cys Gln Ser Leu Met Glu Tyr Asp Phe Cys Cys Ser Lys Cys Arg Lys
  65                  70                  75                  80

 cca gga cag cag aat tat ctg ggt ggt tgt tgg acg tcc agt gtc tca      288
 Pro Gly Gln Gln Asn Tyr Leu Gly Gly Cys Trp Thr Ser Ser Val Ser
                  85                  90                  95

 tgc tgg cct aag gat cgg aat cgg cat ttt aac tac ttc ccg gag gag      336
 Cys Trp Pro Lys Asp Arg Asn Arg His Phe Asn Tyr Phe Pro Glu Glu
             100                 105                 110

 tca ctc atg aat cta gag gaa gac ctg gaa ggt gca tgg gag ttg gag      384
 Ser Leu Met Asn Leu Glu Glu Asp Leu Glu Gly Ala Trp Glu Leu Glu
         115                 120                 125

 aag ggc atg tgg agc ctt agc tca gcg tgg ggt aga gca gcg gct gcc      432
 Lys Gly Met Trp Ser Leu Ser Ser Ala Trp Gly Arg Ala Ala Ala Ala
     130                 135                 140

 atg ctc ttc tgt ggc ttc atc atc ctg gtg atc tgt ttc atc ctc tcc      480
 Met Leu Phe Cys Gly Phe Ile Ile Leu Val Ile Cys Phe Ile Leu Ser
 145                 150                 155                 160

 ttc ttc gcc ctc tgt gga ccc cag atg ctt gtc ttc ctg aga gtg att      528
 Phe Phe Ala Leu Cys Gly Pro Gln Met Leu Val Phe Leu Arg Val Ile
                 165                 170                 175

 gga ggt ctc ctt gcc ttg gct gtc ccc atc cga gtg aca ggg att gtc      576
 Gly Gly Leu Leu Ala Leu Ala Val Pro Ile Arg Val Thr Gly Ile Val
             180                 185                 190

 act cta cat gcc cct atc tct ctt agg ggg ccc tat cca ctg act cct      624
 Thr Leu His Ala Pro Ile Ser Leu Arg Gly Pro Tyr Pro Leu Thr Pro
         195                 200                 205

 cta ccc gag aaa cta ggc tat gtc agc cct gga aaa gca gtg ctc tcc      672
 Leu Pro Glu Lys Leu Gly Tyr Val Ser Pro Gly Lys Ala Val Leu Ser
     210                 215                 220

 gtt gtg gtc ccc agc cct ggc ctg ctg tga                              702
 Val Val Val Pro Ser Pro Gly Leu Leu 
 225                 230





      <210> 889
      <211> 1053
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (1)..(1053)

      <400> 889
  atg agg cgg ctg ctg tcc aag gcc gtg gtg att gat gac gat gac gat      48
  Met Arg Arg Leu Leu Ser Lys Ala Val Val Ile Asp Asp Asp Asp Asp
    1               5                  10                  15

 gac gaa tac ccc tgg agg cag aat gcg cac aga tac tac atc cac ctc       96
 Asp Glu Tyr Pro Trp Arg Gln Asn Ala His Arg Tyr Tyr Ile His Leu
              20                  25                  30

 ctg ctg agc ctc ttc ctc ttc ctc tgg ttc atc ctg gga aac tac tgg      144
 Leu Leu Ser Leu Phe Leu Phe Leu Trp Phe Ile Leu Gly Asn Tyr Trp
          35                  40                  45

 gtc ttt tct gtg tac ctg cct gat ttt ctt ccc cct ttc cag cag cct      192
 Val Phe Ser Val Tyr Leu Pro Asp Phe Leu Pro Pro Phe Gln Gln Pro
      50                  55                  60

 cag gac tac tgt gac aaa acc ctg tac ctc ttt gca gtc gga gtc ctg      240
 Gln Asp Tyr Cys Asp Lys Thr Leu Tyr Leu Phe Ala Val Gly Val Leu
  65                  70                  75                  80

 gcg ctc agt cac act gtg ctg gtc ttg ctc ctg ctg tgc agc ggc tgt      288
 Ala Leu Ser His Thr Val Leu Val Leu Leu Leu Leu Cys Ser Gly Cys
                  85                  90                  95

 gtc tac ctg tgc tcc aga gaa ggg gtt aag cat gtg gca tct gga ccc      336
 Val Tyr Leu Cys Ser Arg Glu Gly Val Lys His Val Ala Ser Gly Pro
             100                 105                 110

 aga ccg tca ggc tgg gat cct ggc tct gcc cct ttc cag atg cgt gtg      384
 Arg Pro Ser Gly Trp Asp Pro Gly Ser Ala Pro Phe Gln Met Arg Val
         115                 120                 125

 atc ttg gat gtg cca ctg aaa ctc tct gtg cct cgt ttt cat tgc gtc      432
 Ile Leu Asp Val Pro Leu Lys Leu Ser Val Pro Arg Phe His Cys Val
     130                 135                 140

 gtg tgg ttc gcc aag ggg ctg cgc gag tac acc aag agt ggc tat gaa      480
 Val Trp Phe Ala Lys Gly Leu Arg Glu Tyr Thr Lys Ser Gly Tyr Glu
 145                 150                 155                 160

 tct gca tgt aaa gac ttt gtc cct cat gac ttg gag gtc cag att cct      528
 Ser Ala Cys Lys Asp Phe Val Pro His Asp Leu Glu Val Gln Ile Pro
                 165                 170                 175

 gga aga gtc ttt ttg gtc act gga gga aac agc ggc att ggc aaa gca      576
 Gly Arg Val Phe Leu Val Thr Gly Gly Asn Ser Gly Ile Gly Lys Ala
             180                 185                 190

 act gcc ctt gaa atc gcc aag cga gat ggt ttc att gaa ttc cac cag      624
 Thr Ala Leu Glu Ile Ala Lys Arg Asp Gly Phe Ile Glu Phe His Gln
         195                 200                 205

 gtg gca cag ttc acc tgg ttt gtc gag atc aag ccc cag cag aag atg      672
 Val Ala Gln Phe Thr Trp Phe Val Glu Ile Lys Pro Gln Gln Lys Met
     210                 215                 220

 cca ggg gtc ttc tgg cct agg agc acc ggc ccc aaa tcc aag tcc tcc      720
 Pro Gly Val Phe Trp Pro Arg Ser Thr Gly Pro Lys Ser Lys Ser Ser
 225                 230                 235                 240

 tgt ggg cca gga cct tac cta att acc tgg ctg gga ttt ggt gtg tac      768
 Cys Gly Pro Gly Pro Tyr Leu Ile Thr Trp Leu Gly Phe Gly Val Tyr
                 245                 250                 255

 att ctc acg acc ggc ctg atc cct gtg ctg gag aaa gaa cac gac ccc      816
 Ile Leu Thr Thr Gly Leu Ile Pro Val Leu Glu Lys Glu His Asp Pro
             260                 265                 270

 cga gtg ata acc gtc tcc tca gga gga atg ttg gtt cag aaa ctg aac      864
 Arg Val Ile Thr Val Ser Ser Gly Gly Met Leu Val Gln Lys Leu Asn
         275                 280                 285

 acc aat gat ctc cag tcc gaa aga aca cca ttt gat gga act atg gtc      912
 Thr Asn Asp Leu Gln Ser Glu Arg Thr Pro Phe Asp Gly Thr Met Val
     290                 295                 300

 tat gca caa aac aag aaa gta gat ttc tac aga tgg agc atc ctt cat      960
 Tyr Ala Gln Asn Lys Lys Val Asp Phe Tyr Arg Trp Ser Ile Leu His
 305                 310                 315                 320

 ctg aaa atc cca aat cca aaa tgc tcc aaa atc caa atc atc ttg agt     1008
 Leu Lys Ile Pro Asn Pro Lys Cys Ser Lys Ile Gln Ile Ile Leu Ser
                 325                 330                 335

 gct gac gat gtc aca agt ggg aaa tcc cac acc ttt gct ttc tga         1053
 Ala Asp Asp Val Thr Ser Gly Lys Ser His Thr Phe Ala Phe 
             340                 345                 350





      <210> 890
      <211> 1845
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (4)..(1845)

      <400> 890
 gtg  atg gat ctc ggc cgc gac gcc acc cgc cgc ttc ttc aac tgg ttt      48
      Met Asp Leu Gly Arg Asp Ala Thr Arg Arg Phe Phe Asn Trp Phe
        1               5                  10                  15

 tac tgg agc atc aac ctg ggt gct gtg ctg tcg ctg ctg gtg gtg gcg       96
 Tyr Trp Ser Ile Asn Leu Gly Ala Val Leu Ser Leu Leu Val Val Ala
                  20                  25                  30

 ttt att cag cag aac atc agc ttc ctg ctg ggc tac agc atc cct gtg      144
 Phe Ile Gln Gln Asn Ile Ser Phe Leu Leu Gly Tyr Ser Ile Pro Val
              35                  40                  45

 ggc tgt gtg ggc ctg gca ttt ttc atc ttc ctc ttt gcc acc ccc gtc      192
 Gly Cys Val Gly Leu Ala Phe Phe Ile Phe Leu Phe Ala Thr Pro Val
          50                  55                  60

 ttc atc acc aag ccc ccg atg ggc agc caa gtg tcc tct atg ctt aag      240
 Phe Ile Thr Lys Pro Pro Met Gly Ser Gln Val Ser Ser Met Leu Lys
      65                  70                  75

 ctc gct ctc caa aac tgc tgc ccc cag ctg tgg caa cga cac tcg gcc      288
 Leu Ala Leu Gln Asn Cys Cys Pro Gln Leu Trp Gln Arg His Ser Ala
  80                  85                  90                  95

 agg aag tgt gag gat gat cag ggt ctt gac agt gaa gat ggt agt aag      336
 Arg Lys Cys Glu Asp Asp Gln Gly Leu Asp Ser Glu Asp Gly Ser Lys
                 100                 105                 110

 gat aag gat gat ggt gtt ggt atc tac act gaa gac aca aac att ggc      384
 Asp Lys Asp Asp Gly Val Gly Ile Tyr Thr Glu Asp Thr Asn Ile Gly
             115                 120                 125

 aat gcg gat gac agt ggc att aaa gga gag gat gat ggg gat gat gtt      432
 Asn Ala Asp Asp Ser Gly Ile Lys Gly Glu Asp Asp Gly Asp Asp Val
         130                 135                 140

 tcc aat gaa ggc ttt ctg agt gac tgg gct cag tcg ggc cgt tct gct      480
 Ser Asn Glu Gly Phe Leu Ser Asp Trp Ala Gln Ser Gly Arg Ser Ala
     145                 150                 155

 tct cgt gat ggc gct ggg gtt gca gtc att tgg gac ctg gaa agg gct      528
 Ser Arg Asp Gly Ala Gly Val Ala Val Ile Trp Asp Leu Glu Arg Ala
 160                 165                 170                 175

 aga act tct gag tct gct cac tta cat ggc tgg cag tca atg tgg gct      576
 Arg Thr Ser Glu Ser Ala His Leu His Gly Trp Gln Ser Met Trp Ala
                 180                 185                 190

 gtt ggc tgt gag ctc aga tgg gac tgt gtg gac cag agc acc ttg gtt      624
 Val Gly Cys Glu Leu Arg Trp Asp Cys Val Asp Gln Ser Thr Leu Val
             195                 200                 205

 ccc att cgt gtg gtc tta cca tgt ggc ttg aac ttc tca cag cgt cgt      672
 Pro Ile Arg Val Val Leu Pro Cys Gly Leu Asn Phe Ser Gln Arg Arg
         210                 215                 220

 gtc aag ctg tca caa ggc cag cag gga aac aat ggc agt gaa agt aaa      720
 Val Lys Leu Ser Gln Gly Gln Gln Gly Asn Asn Gly Ser Glu Ser Lys
     225                 230                 235

 ctc cac ctg ttg gtg gca aaa tgg cag cac acg ctg gga agg gtg gag      768
 Leu His Leu Leu Val Ala Lys Trp Gln His Thr Leu Gly Arg Val Glu
 240                 245                 250                 255

 ttg aca gtg gct gtc ttt gga gat gac tac act aat att gtc cct ttt      816
 Leu Thr Val Ala Val Phe Gly Asp Asp Tyr Thr Asn Ile Val Pro Phe
                 260                 265                 270

 gga atc tca aag gac agt gca agg ctc ttg gac aaa aag aga gac cgt      864
 Gly Ile Ser Lys Asp Ser Ala Arg Leu Leu Asp Lys Lys Arg Asp Arg
             275                 280                 285

 caa tgt gcc cgc gtg ctg gcc gac gag agg tct ccc cag cca ggg gct      912
 Gln Cys Ala Arg Val Leu Ala Asp Glu Arg Ser Pro Gln Pro Gly Ala
         290                 295                 300

 tcc ccg caa gag gac atc gcc aac ttc cag gtg ctg gtg aag atc ttg      960
 Ser Pro Gln Glu Asp Ile Ala Asn Phe Gln Val Leu Val Lys Ile Leu
     305                 310                 315

 ccc gtc atg gtg acc ctg gtg ccc tac tgg atg gtc tac ttc cag atg     1008
 Pro Val Met Val Thr Leu Val Pro Tyr Trp Met Val Tyr Phe Gln Met
 320                 325                 330                 335

 cag tcc acc tat gtc ctg cag ggt ctt cac ctc cac atc cca aac att     1056
 Gln Ser Thr Tyr Val Leu Gln Gly Leu His Leu His Ile Pro Asn Ile
                 340                 345                 350

 ttc cca gcc aac ccg gcc aac atc tct gtg gcc ctg aga gcc cag ggc     1104
 Phe Pro Ala Asn Pro Ala Asn Ile Ser Val Ala Leu Arg Ala Gln Gly
             355                 360                 365

 agc agc tac acg atc ccg gaa gcc tgg ctc ctc ctg gcc aat gtt gtg     1152
 Ser Ser Tyr Thr Ile Pro Glu Ala Trp Leu Leu Leu Ala Asn Val Val
         370                 375                 380

 gtg gtg ctg att ctg gtc cct ctg aag gac cgc ttg atc gac cct tta     1200
 Val Val Leu Ile Leu Val Pro Leu Lys Asp Arg Leu Ile Asp Pro Leu
     385                 390                 395

 ctg ctg cgg tgc aag ctg ctt ccc tct gct ctg cag aag atg gcg ctg     1248
 Leu Leu Arg Cys Lys Leu Leu Pro Ser Ala Leu Gln Lys Met Ala Leu
 400                 405                 410                 415

 ggg atg ttc ttt ggt ttt acc tcc gtc att gtg gca gga gtc ctg gag     1296
 Gly Met Phe Phe Gly Phe Thr Ser Val Ile Val Ala Gly Val Leu Glu
                 420                 425                 430

 atg gag cgc tta cac tac atc cac cac aac gag acc gtg tcc cag cag     1344
 Met Glu Arg Leu His Tyr Ile His His Asn Glu Thr Val Ser Gln Gln
             435                 440                 445

 att ggg gag gtc ctg tac aac gcg gca cca ctg tcc atc tgg tgg cag     1392
 Ile Gly Glu Val Leu Tyr Asn Ala Ala Pro Leu Ser Ile Trp Trp Gln
         450                 455                 460

 atc cct cag tac ctg ctc att ggg atc agt gag atc ttt gcc agc atc     1440
 Ile Pro Gln Tyr Leu Leu Ile Gly Ile Ser Glu Ile Phe Ala Ser Ile
     465                 470                 475

 cca ggc ctg gag ttt gcc tac tca gag gcc ccg cgc tcc atg cag ggc     1488
 Pro Gly Leu Glu Phe Ala Tyr Ser Glu Ala Pro Arg Ser Met Gln Gly
 480                 485                 490                 495

 gcc atc atg ggc atc ttc ttc tgc ctg tcg ggg gtg ggc tca ctg ttg     1536
 Ala Ile Met Gly Ile Phe Phe Cys Leu Ser Gly Val Gly Ser Leu Leu
                 500                 505                 510

 ggc tcc agc cta gtg gca ctg ctg tcc ttg ccc ggg ggc tgg ctg cac     1584
 Gly Ser Ser Leu Val Ala Leu Leu Ser Leu Pro Gly Gly Trp Leu His
             515                 520                 525

 tgc ccc aag gac ttt gtt gcc agc ccc agt gct agt gac acg gca ggc     1632
 Cys Pro Lys Asp Phe Val Ala Ser Pro Ser Ala Ser Asp Thr Ala Gly
         530                 535                 540

 aca ggg cgc aag aca gag gat ccc tgt act gac cca aat cta acc cct     1680
 Thr Gly Arg Lys Thr Glu Asp Pro Cys Thr Asp Pro Asn Leu Thr Pro
     545                 550                 555

 cct ttc ccc agg aac atc aac aat tgc cgg atg gac ctc tac ttc ttc     1728
 Pro Phe Pro Arg Asn Ile Asn Asn Cys Arg Met Asp Leu Tyr Phe Phe
 560                 565                 570                 575

 ctg ctg gct ggc att cag gcc gtc acg gct ctc cta ttt gtc tgg atc     1776
 Leu Leu Ala Gly Ile Gln Ala Val Thr Ala Leu Leu Phe Val Trp Ile
                 580                 585                 590

 gct gga cgc tat gag agg gcg tcc cag ggc cca gcc tcc cac agc cgt     1824
 Ala Gly Arg Tyr Glu Arg Ala Ser Gln Gly Pro Ala Ser His Ser Arg
             595                 600                 605

 ttc agc agg gac agg ggc tga                                         1845
 Phe Ser Arg Asp Arg Gly 
         610





      <210> 891
      <211> 3162
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (1)..(3162)

      <400> 891
  atg tgg gcc gga ctg ctc ctt cgg gcc gcc tgt gtc gcg ctc ctg ctg      48
  Met Trp Ala Gly Leu Leu Leu Arg Ala Ala Cys Val Ala Leu Leu Leu
    1               5                  10                  15

 ccg ggg gca cca gcc cga ggc tac acc ggg agg aag ccg ccc ggg cac       96
 Pro Gly Ala Pro Ala Arg Gly Tyr Thr Gly Arg Lys Pro Pro Gly His
              20                  25                  30

 ttc gcg gcc gag agc cgg ggc tgc ccc cac tgt gtc tgg cag ctt cca      144
 Phe Ala Ala Glu Ser Arg Gly Cys Pro His Cys Val Trp Gln Leu Pro
          35                  40                  45

 ata ttg ctt tcc tgc tgc cat aag atg gca ggt ctg gca aca gaa gtg      192
 Ile Leu Leu Ser Cys Cys His Lys Met Ala Gly Leu Ala Thr Glu Val
      50                  55                  60

 gag ccg gac tta agg aga aag agg aag gaa ctt cag ctc tgg cac ctg      240
 Glu Pro Asp Leu Arg Arg Lys Arg Lys Glu Leu Gln Leu Trp His Leu
  65                  70                  75                  80

 cag acc ccc gaa agt gac cta cgg aag ctg gca gca ggg act gca att      288
 Gln Thr Pro Glu Ser Asp Leu Arg Lys Leu Ala Ala Gly Thr Ala Ile
                  85                  90                  95

 gag cac tct ctc acc ttt ccc ttc tca gag ctc ccc aag cct atg ccc      336
 Glu His Ser Leu Thr Phe Pro Phe Ser Glu Leu Pro Lys Pro Met Pro
             100                 105                 110

 aga gca gcc att cct tct ctg cag ctc acc ttg gca gct gtg gcg gtc      384
 Arg Ala Ala Ile Pro Ser Leu Gln Leu Thr Leu Ala Ala Val Ala Val
         115                 120                 125

 ggc aga cag ctg cat gcc cgg ccc aca ctc gca cac aaa ccc acc ttc      432
 Gly Arg Gln Leu His Ala Arg Pro Thr Leu Ala His Lys Pro Thr Phe
     130                 135                 140

 tgt gtt cac aca gtg gcc ctc gca gga gga ggt tac aca ttc gtc aat      480
 Cys Val His Thr Val Ala Leu Ala Gly Gly Gly Tyr Thr Phe Val Asn
 145                 150                 155                 160

 gtc tgg aaa gac aga aag cac gtg ttt aca cag tgg tcc tcg caa gag      528
 Val Trp Lys Asp Arg Lys His Val Phe Thr Gln Trp Ser Ser Gln Glu
                 165                 170                 175

 gaa ctt aca cat tta caa caa aca ccg ccc tac acc tac agc agc agc      576
 Glu Leu Thr His Leu Gln Gln Thr Pro Pro Tyr Thr Tyr Ser Ser Ser
             180                 185                 190

 tcc tcg cca aag cac aac aac cct ccc tct agc cct cca cac aac aca      624
 Ser Ser Pro Lys His Asn Asn Pro Pro Ser Ser Pro Pro His Asn Thr
         195                 200                 205

 ata ctc ctt atc tct cct cct cac cta cat cgt cct ctc ttg aaa ggg      672
 Ile Leu Leu Ile Ser Pro Pro His Leu His Arg Pro Leu Leu Lys Gly
     210                 215                 220

 ttc gcc gtc att cat gtg tct cct cgg ttg gta act aca cgt cta ggt      720
 Phe Ala Val Ile His Val Ser Pro Arg Leu Val Thr Thr Arg Leu Gly
 225                 230                 235                 240

 cct cac tat att gcc ttg cac tgt gag atg ttc gca cca aag gtg ggg      768
 Pro His Tyr Ile Ala Leu His Cys Glu Met Phe Ala Pro Lys Val Gly
                 245                 250                 255

 ctc agt gtc ctc atg gta agt gga aac aac agt gac ggt gcc cac tgc      816
 Leu Ser Val Leu Met Val Ser Gly Asn Asn Ser Asp Gly Ala His Cys
             260                 265                 270

 atg ggc cct ggc cta aga gga aaa gaa acc aca ttg gtc aca ccc cag      864
 Met Gly Pro Gly Leu Arg Gly Lys Glu Thr Thr Leu Val Thr Pro Gln
         275                 280                 285

 gac agc cct gga aag tgc cca atc aac ggt cgc tct gag gag gca aca      912
 Asp Ser Pro Gly Lys Cys Pro Ile Asn Gly Arg Ser Glu Glu Ala Thr
     290                 295                 300

 gca gat ggt cac aca aat gga cga aca aaa aaa ttc atg tct tct ccc      960
 Ala Asp Gly His Thr Asn Gly Arg Thr Lys Lys Phe Met Ser Ser Pro
 305                 310                 315                 320

 ctc act ttc cac agc gat gac aag agt ggc agc gtg gtg atc ttt ggt     1008
 Leu Thr Phe His Ser Asp Asp Lys Ser Gly Ser Val Val Ile Phe Gly
                 325                 330                 335

 ggc att gac tct tct tac tac act gga agt ctg aac tgg gtg cct gtt     1056
 Gly Ile Asp Ser Ser Tyr Tyr Thr Gly Ser Leu Asn Trp Val Pro Val
             340                 345                 350

 acc gtc gag ggt tac tgg cag atc acc gtg gac agc atc acc atg aac     1104
 Thr Val Glu Gly Tyr Trp Gln Ile Thr Val Asp Ser Ile Thr Met Asn
         355                 360                 365

 gga gag acc atc gcc tgt gct gag ggc tgc cag gcc att gtt gac acc     1152
 Gly Glu Thr Ile Ala Cys Ala Glu Gly Cys Gln Ala Ile Val Asp Thr
     370                 375                 380

 ggc acc tct ctg ctg acc ggc cca acc agc ccc att gcc aac atc cag     1200
 Gly Thr Ser Leu Leu Thr Gly Pro Thr Ser Pro Ile Ala Asn Ile Gln
 385                 390                 395                 400

 agc gac atc gga gcc agc gag aac tca gat ggc gac atg gtg gtc agc     1248
 Ser Asp Ile Gly Ala Ser Glu Asn Ser Asp Gly Asp Met Val Val Ser
                 405                 410                 415

 tgc tca gcc atc agc agc ctg ccc gac atc gtc ttc acc atc aat gga     1296
 Cys Ser Ala Ile Ser Ser Leu Pro Asp Ile Val Phe Thr Ile Asn Gly
             420                 425                 430

 gtc cag tac ccc gtg cca ccc agt gcc tac atc ctg cag ctt tgg atc     1344
 Val Gln Tyr Pro Val Pro Pro Ser Ala Tyr Ile Leu Gln Leu Trp Ile
         435                 440                 445

 ctg ggt gat gtc ttc atc cgc cag tac ttt acc tct tct aca gtg cat     1392
 Leu Gly Asp Val Phe Ile Arg Gln Tyr Phe Thr Ser Ser Thr Val His
     450                 455                 460

 aca acc agg tcg gcc tgg cgc gtg tgg ttt aag cac act gac gaa tgc     1440
 Thr Thr Arg Ser Ala Trp Arg Val Trp Phe Lys His Thr Asp Glu Cys
 465                 470                 475                 480

 cta ggg act ccc tgt cag cag aga tgt aaa aac agc att ggc agc tac     1488
 Leu Gly Thr Pro Cys Gln Gln Arg Cys Lys Asn Ser Ile Gly Ser Tyr
                 485                 490                 495

 aag tgt tcc tgt cga act ggc ttc cac ctt cat ggc aac cgg cac tcc     1536
 Lys Cys Ser Cys Arg Thr Gly Phe His Leu His Gly Asn Arg His Ser
             500                 505                 510

 tgt gta gag aaa gtc ccc aag tgc ttt gag cta agg gac ggg cgg aag     1584
 Cys Val Glu Lys Val Pro Lys Cys Phe Glu Leu Arg Asp Gly Arg Lys
         515                 520                 525

 aag ggc tcc gta gcc caa aca aag cag ctg tcc gca gcg agg acc tcc     1632
 Lys Gly Ser Val Ala Gln Thr Lys Gln Leu Ser Ala Ala Arg Thr Ser
     530                 535                 540

 cgc aga cgc aaa cga gtg tcg gac gcc atc gga gac gcg agt ctg tca     1680
 Arg Arg Arg Lys Arg Val Ser Asp Ala Ile Gly Asp Ala Ser Leu Ser
 545                 550                 555                 560

 cca ttc ctg cca caa cac cgt ggg cag ctt cgt atg cac atg cgg acc     1728
 Pro Phe Leu Pro Gln His Arg Gly Gln Leu Arg Met His Met Arg Thr
                 565                 570                 575

 tgg ttt cag gac ggg aag gtg acc tgt gaa aag gcc agt gag ggc aag     1776
 Trp Phe Gln Asp Gly Lys Val Thr Cys Glu Lys Ala Ser Glu Gly Lys
             580                 585                 590

 cgt gtg acg agc ttt gtt aac ttt ttc gct gca tgt gat gcc cgt gta     1824
 Arg Val Thr Ser Phe Val Asn Phe Phe Ala Ala Cys Asp Ala Arg Val
         595                 600                 605

 aca gat agt tat tct gag gat cac tct cct tta gtg atg aag tgg gtg     1872
 Thr Asp Ser Tyr Ser Glu Asp His Ser Pro Leu Val Met Lys Trp Val
     610                 615                 620

 ctg ttc ctg gac ata aag gca gac ctg tgc ttc aca tgg att gat ctg     1920
 Leu Phe Leu Asp Ile Lys Ala Asp Leu Cys Phe Thr Trp Ile Asp Leu
 625                 630                 635                 640

 tct tct ggc agt gaa gtg cag gtg ctg ctg ctg cct cca ctg tac tca     1968
 Ser Ser Gly Ser Glu Val Gln Val Leu Leu Leu Pro Pro Leu Tyr Ser
                 645                 650                 655

 gac cca ggt agc aca gga ttg tcc atc ttc cag cag ctc agt gca cgg     2016
 Asp Pro Gly Ser Thr Gly Leu Ser Ile Phe Gln Gln Leu Ser Ala Arg
             660                 665                 670

 tgt gaa ctc agc ctg ttt cag agc ctc cac acc atg acc tcc aag aag     2064
 Cys Glu Leu Ser Leu Phe Gln Ser Leu His Thr Met Thr Ser Lys Lys
         675                 680                 685

 ctg gtg aac tcg gtg gct ggc tgt gct gat gac gct ctt gct ggc ctg     2112
 Leu Val Asn Ser Val Ala Gly Cys Ala Asp Asp Ala Leu Ala Gly Leu
     690                 695                 700

 gtg gcc tgc aac ccc aac ctg cag ctc ctg cag ggc cac cgc gtg gcc     2160
 Val Ala Cys Asn Pro Asn Leu Gln Leu Leu Gln Gly His Arg Val Ala
 705                 710                 715                 720

 ctc cgt tct gac ctg gac agc ctc aag ggc cgg gtg gca ctg ctg tcg     2208
 Leu Arg Ser Asp Leu Asp Ser Leu Lys Gly Arg Val Ala Leu Leu Ser
                 725                 730                 735

 ggt ggg ggc tct ggc cat gag cct gcc cat gct gca aaa tcc att cat     2256
 Gly Gly Gly Ser Gly His Glu Pro Ala His Ala Ala Lys Ser Ile His
             740                 745                 750

 ttg gca aac act cat gag ccc act gtg tac ctg gcg ctg tac tgg gca     2304
 Leu Ala Asn Thr His Glu Pro Thr Val Tyr Leu Ala Leu Tyr Trp Ala
         755                 760                 765

 cta ggg ata cca gac agg caa ggt ttc ata ggg aag ggg atg ctg act     2352
 Leu Gly Ile Pro Asp Arg Gln Gly Phe Ile Gly Lys Gly Met Leu Thr
     770                 775                 780

 ggg gtc atc gcg gga gct gtg ttc acc tcc ccg gca gtg ggc agc atc     2400
 Gly Val Ile Ala Gly Ala Val Phe Thr Ser Pro Ala Val Gly Ser Ile
 785                 790                 795                 800

 ctg gca gcc atc acg gcc gtg gcc cag cct ccc aca cgc aag cgt cgc     2448
 Leu Ala Ala Ile Thr Ala Val Ala Gln Pro Pro Thr Arg Lys Arg Arg
                 805                 810                 815

 atg cac cac ggc att ggg ggc gcc tct ggg ggt tcg acc ccg gtc ggc     2496
 Met His His Gly Ile Gly Gly Ala Ser Gly Gly Ser Thr Pro Val Gly
             820                 825                 830

 ccc aac gcc cgc tcc gac gga acc tct cca gtc gcc gct gcc ctc cgc     2544
 Pro Asn Ala Arg Ser Asp Gly Thr Ser Pro Val Ala Ala Ala Leu Arg
         835                 840                 845

 caa acc ccc agg ggc ctc cga tgg ggc cag agc gca gtc cgc agg ggg     2592
 Gln Thr Pro Arg Gly Leu Arg Trp Gly Gln Ser Ala Val Arg Arg Gly
     850                 855                 860

 gtt tac cgc gtc ctg agc gga gtg gtc ccc ttc acg gtt cgt ggg gca     2640
 Val Tyr Arg Val Leu Ser Gly Val Val Pro Phe Thr Val Arg Gly Ala
 865                 870                 875                 880

 cca gct ggg tgc tgc agc ccc gga ggg gtg ctg ttg ggg tcg caa act     2688
 Pro Ala Gly Cys Cys Ser Pro Gly Gly Val Leu Leu Gly Ser Gln Thr
                 885                 890                 895

 cga gta act gag aca ccg cgg tgg acc gtg aag acc atg gtc aac acc     2736
 Arg Val Thr Glu Thr Pro Arg Trp Thr Val Lys Thr Met Val Asn Thr
             900                 905                 910

 gct gag aag ccc agt ctg act aac ccc att cca ctg gga tgt gtc gtg     2784
 Ala Glu Lys Pro Ser Leu Thr Asn Pro Ile Pro Leu Gly Cys Val Val
         915                 920                 925

 gct aca gtc agt gcc acc ctg tcc tgc aag tgc ttt gac att gtt ctc     2832
 Ala Thr Val Ser Ala Thr Leu Ser Cys Lys Cys Phe Asp Ile Val Leu
     930                 935                 940

 tgg ctt ttc ctt ggt tcc gtt tgc ctc tgc aat gag aaa tac gtg cag     2880
 Trp Leu Phe Leu Gly Ser Val Cys Leu Cys Asn Glu Lys Tyr Val Gln
 945                 950                 955                 960

 aaa atg tcc caa gcc ctc tgc tcc ttc ggc tgt ggg agt ggc atc tgc     2928
 Lys Met Ser Gln Ala Leu Cys Ser Phe Gly Cys Gly Ser Gly Ile Cys
                 965                 970                 975

 atc gct ccc aat gtc tgc tcc tgc cag gat gga gag caa ggg gcc acc     2976
 Ile Ala Pro Asn Val Cys Ser Cys Gln Asp Gly Glu Gln Gly Ala Thr
             980                 985                 990

 tgc cca gaa acc cat gga cca tgt ggg gag tac ggc tgt gac ctt acc     3024
 Cys Pro Glu Thr His Gly Pro Cys Gly Glu Tyr Gly Cys Asp Leu Thr
         995                1000                1005

 tgc aac cat gga ggc tgt cag gag gtg gcc cga gtg tgc ccc gtg ggc     3072
 Cys Asn His Gly Gly Cys Gln Glu Val Ala Arg Val Cys Pro Val Gly
    1010                1015                1020

 ttc tcg atg acg gag aca gct gtt ggc atc agg tgt aca gga tgg tct     3120
 Phe Ser Met Thr Glu Thr Ala Val Gly Ile Arg Cys Thr Gly Trp Ser
1025                1030                1035                1040

 cca gtg tat tgc aag gct aag ctg agc caa gat agg ctc tga             3162
 Pro Val Tyr Cys Lys Ala Lys Leu Ser Gln Asp Arg Leu 
                1045                1050





      <210> 892
      <211> 939
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (1)..(939)

      <400> 892
  atg gcc tct ctt ggc ctc caa ctt gtg ggc tac atc cta ggc ctt ctg      48
  Met Ala Ser Leu Gly Leu Gln Leu Val Gly Tyr Ile Leu Gly Leu Leu
    1               5                  10                  15

 ggg ctt ttg ggc aca ctg gtt gcc atg ctg ctc ccc agc tgg aaa aca       96
 Gly Leu Leu Gly Thr Leu Val Ala Met Leu Leu Pro Ser Trp Lys Thr
              20                  25                  30

 agt tct tat gtc ggt gcc agc att gtg aca gca gtt ggc ttc tcc aag      144
 Ser Ser Tyr Val Gly Ala Ser Ile Val Thr Ala Val Gly Phe Ser Lys
          35                  40                  45

 ggc ctc tgg atg gaa tgt gcc aca cac agc aca ggc atc acc cag tgt      192
 Gly Leu Trp Met Glu Cys Ala Thr His Ser Thr Gly Ile Thr Gln Cys
      50                  55                  60

 gac atc tat agc acc ctt ctg ggc ctg ccc gct gac atc cag gct gcc      240
 Asp Ile Tyr Ser Thr Leu Leu Gly Leu Pro Ala Asp Ile Gln Ala Ala
  65                  70                  75                  80

 cag gcc atg atg gtg aca tcc agt gca atc tcc tcc ctg gcc tgc att      288
 Gln Ala Met Met Val Thr Ser Ser Ala Ile Ser Ser Leu Ala Cys Ile
                  85                  90                  95

 atc tct gtg gtg ggc atg aga tgc aca gtc ttc tgc cag gaa tcc cga      336
 Ile Ser Val Val Gly Met Arg Cys Thr Val Phe Cys Gln Glu Ser Arg
             100                 105                 110

 gcc aaa gac aga gtg gcg gta gca ggt gga gtc ttt ttc atc ctt gga      384
 Ala Lys Asp Arg Val Ala Val Ala Gly Gly Val Phe Phe Ile Leu Gly
         115                 120                 125

 ggc ctc ctg gga ttc att cct gtt gcc tgg aat ctt cat ggg atc cta      432
 Gly Leu Leu Gly Phe Ile Pro Val Ala Trp Asn Leu His Gly Ile Leu
     130                 135                 140

 cgg gac ttc tac tca cca ctg gtg cct gac agc atg aaa ttt gag att      480
 Arg Asp Phe Tyr Ser Pro Leu Val Pro Asp Ser Met Lys Phe Glu Ile
 145                 150                 155                 160

 gga gag gct ctt tac ttg ggc att att tct tcc ctg ttc tcc ctg ata      528
 Gly Glu Ala Leu Tyr Leu Gly Ile Ile Ser Ser Leu Phe Ser Leu Ile
                 165                 170                 175

 gct gga atc atc ctc tgc ttt tcc tgc tca tcc cag aga aat cgc tcc      576
 Ala Gly Ile Ile Leu Cys Phe Ser Cys Ser Ser Gln Arg Asn Arg Ser
             180                 185                 190

 aac tac tac gat gcc tac caa gcc caa cct ctt gcc aca agg agc tct      624
 Asn Tyr Tyr Asp Ala Tyr Gln Ala Gln Pro Leu Ala Thr Arg Ser Ser
         195                 200                 205

 cca agg cct ggt caa cct ccc aaa gtc aag acc cta gtg acc cac tgc      672
 Pro Arg Pro Gly Gln Pro Pro Lys Val Lys Thr Leu Val Thr His Cys
     210                 215                 220

 tat gtg atc att aat ggg cga aga agg act gaa act ggc ttc tta gtg      720
 Tyr Val Ile Ile Asn Gly Arg Arg Arg Thr Glu Thr Gly Phe Leu Val
 225                 230                 235                 240

 gaa agg caa gct cca act ttc gga aag acc ttt gtc cag cca ttc aaa      768
 Glu Arg Gln Ala Pro Thr Phe Gly Lys Thr Phe Val Gln Pro Phe Lys
                 245                 250                 255

 cag cta tct gct ggc cag ccc aca ctc act gaa ctc tta ctc tgt gtc      816
 Gln Leu Ser Ala Gly Gln Pro Thr Leu Thr Glu Leu Leu Leu Cys Val
             260                 265                 270

 agg aaa tgt gca aag ggc ttt gag ggc gat gag agt gaa caa ggt ttc      864
 Arg Lys Cys Ala Lys Gly Phe Glu Gly Asp Glu Ser Glu Gln Gly Phe
         275                 280                 285

 cag ggc cta tct gga aga tca gac ctt ctg gaa cac ttt cct gag cct      912
 Gln Gly Leu Ser Gly Arg Ser Asp Leu Leu Glu His Phe Pro Glu Pro
     290                 295                 300

 ctg tct aaa gtc atc ttg cct gcc tga                                  939
 Leu Ser Lys Val Ile Leu Pro Ala 
 305                 310





      <210> 893
      <211> 1284
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (1140)..(1284)

      <400> 893
 atgagctccc tggtggccct agagcgcaag gaccgctatg gtctctctta tgataaccag     60

 ttgtcacaga caaggacgca ctgctcactg gatctaaatg tggtggagac tgtgacctct    120

 tggtccttct ttctctgcca actgctcacc cccttaccct ccatgcaccc ctgtggccag    180

 gcactgtggg aggcattacg agtacaaagg aacacaacaa acagcctcac ggtggcctgt    240

 cccttctctc ctgaccagtt tcggggcacc agctgttggc ctgaacacct aggagtgtat    300

 gggtcacact ggcatgtgca gctcattgta ctcatcctgg ccatcctcat cgaagtttgg    360

 ttcagcatct tccgagtcca gctgcagagg gaacagaaga tccctctgga tccccttccc    420

 gtcaccccac tgccctaccc ccatgcttcc cggccctacc ttggtcacat agggctgctc    480

 aggatggtgt tttgccggca tgaggatgag caacagacgc tgggacagct ggataccaga    540

 cagggacgtg acccccatgt acaggaagat cccaaagagc acagccaatg ggatccgacg    600

 cagcacagcc cccatgacga tggacaggcc tggaggaggc gcgatggcag tacgcatcac    660

 tgtcaacgca ttgacatggg tgacggagcg gaccgtggca gccgtgagcc agggcaaccc    720

 aaacagccca cagagccccc ccagggagcc aatgaggagc aggtccaggt ggaaaccgga    780

 gcccttgagc agcctccgcg ccttctggct gacgataagc ctgcagggag aaggaagcgg    840

 ctgttcctga acttgcgcag gaagaaggct atgaagaagg tcccgagcat gaggatgatt    900

 ctccatacct ccccctccca tgctgtcctc cccagggcaa tgtccacctc catctctgcc    960

 acccccaaga cctcgctgga cctccacctt gtagagcttg tagaaggtct cgtagatgaa   1020

 aatgagtgga ctgccctggg tgtcaatgcc ccctggaata ggcagcggat gaactccgag   1080

 gaagagggag aatgcaggga cccatcccct aggggccgtg tagccacccc gtgtggtca    1139                                                                 
 tct cga ctt tgg tct gtt cac gct ctc gcc gct tcc taa gca gct ctc     1187
 Met Thr Thr Arg Gly Gly Tyr Thr Ala Pro Arg Gly Trp Val Pro Ala
   1               5                  10                  15

 gct gga aag cag cca cgg agc gca gca ggt cac ggc cct cca cct cgg     1235
 Phe Ser Leu Phe Leu Gly Val His Pro Leu Pro Ile Pro Gly Gly Ile
              20                  25                  30

 acg ggg gga tca caa tgc tgc cat cca gga act cgc tga tgg cac tta     1283
 Asp Thr Gln Gly Ser Pro Leu Ile Phe Ile Tyr Glu Thr Phe Tyr Lys
          35                  40                  45

 g                                                                   1284
 Leu Tyr Lys Val Glu Val Gln Arg Gly Leu Gly Gly Gly Arg Asp Gly 
      50                  55                  60





      <210> 894
      <211> 4917
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (1)..(4917)

      <400> 894
  atg ttg cgg gct ggg tgg ctc cgg ggc gcg gcg gcg ctg gcg ctg ctg      48
  Met Leu Arg Ala Gly Trp Leu Arg Gly Ala Ala Ala Leu Ala Leu Leu
    1               5                  10                  15

 ctg gcg gcc cga gtg gtg gcg gcg ttc gag ccc atc acc gtg ggc cta       96
 Leu Ala Ala Arg Val Val Ala Ala Phe Glu Pro Ile Thr Val Gly Leu
              20                  25                  30

 gcc atc ggg gcc gcg tcg gcc atc acc ggc tac ctg tcc tac aat gac      144
 Ala Ile Gly Ala Ala Ser Ala Ile Thr Gly Tyr Leu Ser Tyr Asn Asp
          35                  40                  45

 atc tac tgc cgc ttc gcc gag tgc tgc cgc gag gag cgg ccg ctc aac      192
 Ile Tyr Cys Arg Phe Ala Glu Cys Cys Arg Glu Glu Arg Pro Leu Asn
      50                  55                  60

 gct tcg gct ctc aag ctg gat ttg gag gag aag ctg ttt gga cag cat      240
 Ala Ser Ala Leu Lys Leu Asp Leu Glu Glu Lys Leu Phe Gly Gln His
  65                  70                  75                  80

 cta gcc acg gaa gtg att ttc aag gcg ctg act ggc ttc agg aac aac      288
 Leu Ala Thr Glu Val Ile Phe Lys Ala Leu Thr Gly Phe Arg Asn Asn
                  85                  90                  95

 aaa aat ccc aag aaa cca ctg acc ctt tcc tta cac ggc tgg gct ggc      336
 Lys Asn Pro Lys Lys Pro Leu Thr Leu Ser Leu His Gly Trp Ala Gly
             100                 105                 110

 aca ggc aag aat ttt gtc agt caa att gtg gct gaa aat ctt cac cca      384
 Thr Gly Lys Asn Phe Val Ser Gln Ile Val Ala Glu Asn Leu His Pro
         115                 120                 125

 aaa ggt ctg aag agt aac ttt gtc cac ctg ttt gac cag tta cag aag      432
 Lys Gly Leu Lys Ser Asn Phe Val His Leu Phe Asp Gln Leu Gln Lys
     130                 135                 140

 tgg atc cgc ggt aat gtg agt gca tgt gcg aac tct gtt ttc ata ttt      480
 Trp Ile Arg Gly Asn Val Ser Ala Cys Ala Asn Ser Val Phe Ile Phe
 145                 150                 155                 160

 gac gag atg gat aaa ttg cac ccc ggg atc att gac gca atc aag ccg      528
 Asp Glu Met Asp Lys Leu His Pro Gly Ile Ile Asp Ala Ile Lys Pro
                 165                 170                 175

 ttt cta gac tac tac gag cag gtt gac gga gtg tct tac cgc aaa gcc      576
 Phe Leu Asp Tyr Tyr Glu Gln Val Asp Gly Val Ser Tyr Arg Lys Ala
             180                 185                 190

 atc ttc atc ttt ctc agc aat gca ggc ggg gac ctt ata act aag acg      624
 Ile Phe Ile Phe Leu Ser Asn Ala Gly Gly Asp Leu Ile Thr Lys Thr
         195                 200                 205

 gct ctt gac ttt tgg cgg gcc gga aga aag agg gaa gac att cag ctg      672
 Ala Leu Asp Phe Trp Arg Ala Gly Arg Lys Arg Glu Asp Ile Gln Leu
     210                 215                 220

 aag gac ctg gaa cct gta ctg tct gtc gga gtc ttc aat aat aaa cac      720
 Lys Asp Leu Glu Pro Val Leu Ser Val Gly Val Phe Asn Asn Lys His
 225                 230                 235                 240

 act gct aat aca gcc ctg gct gtg gaa tcc ttc acc gtc tca gct ggt      768
 Thr Ala Asn Thr Ala Leu Ala Val Glu Ser Phe Thr Val Ser Ala Gly
                 245                 250                 255

 atc agc ccc agc ctg cct tgt gcc ata tct cag ctt gga tct ctg cta      816
 Ile Ser Pro Ser Leu Pro Cys Ala Ile Ser Gln Leu Gly Ser Leu Leu
             260                 265                 270

 gag tcc ccc caa cca tat atc ata gag ttg aat cac aat gag acc gtt      864
 Glu Ser Pro Gln Pro Tyr Ile Ile Glu Leu Asn His Asn Glu Thr Val
         275                 280                 285

 ggc ttt gaa ttt gag tcg ttg gtt ccc atg ggc agg aaa caa tct cag      912
 Gly Phe Glu Phe Glu Ser Leu Val Pro Met Gly Arg Lys Gln Ser Gln
     290                 295                 300

 atg gtg ctt gga gtg gcg aat gcc aca cag cag aac gga cat gga gag      960
 Met Val Leu Gly Val Ala Asn Ala Thr Gln Gln Asn Gly His Gly Glu
 305                 310                 315                 320

 cgg gag gtg gag cag gct ggg cag gac ctc agg gca gag ccc gag caa     1008
 Arg Glu Val Glu Gln Ala Gly Gln Asp Leu Arg Ala Glu Pro Glu Gln
                 325                 330                 335

 caa gga ccc agc cac gca gac cca gga gtg acg gca gaa cag ggt gca     1056
 Gln Gly Pro Ser His Ala Asp Pro Gly Val Thr Ala Glu Gln Gly Ala
             340                 345                 350

 gga tta gga acc aga tgg gac tgg cgg tgg atg gcc cta ctc act gtt     1104
 Gly Leu Gly Thr Arg Trp Asp Trp Arg Trp Met Ala Leu Leu Thr Val
         355                 360                 365

 ctt gtt att gaa aac cga cac aga caa cgc gtg ttc aat gtc ttt gag     1152
 Leu Val Ile Glu Asn Arg His Arg Gln Arg Val Phe Asn Val Phe Glu
     370                 375                 380

 ctt gat gtc ttc cct ctg ctt tcc act cct cca gaa atc caa agc cac     1200
 Leu Asp Val Phe Pro Leu Leu Ser Thr Pro Pro Glu Ile Gln Ser His
 385                 390                 395                 400

 atc tgt gat cct ttc tgc tcc agc att gct gca aaa caa tcc cag tgg     1248
 Ile Cys Asp Pro Phe Cys Ser Ser Ile Ala Ala Lys Gln Ser Gln Trp
                 405                 410                 415

 gtg gac ata gtc act gtt cag acc acc ctc gta aat att ctc tgc gat     1296
 Val Asp Ile Val Thr Val Gln Thr Thr Leu Val Asn Ile Leu Cys Asp
             420                 425                 430

 gat ctt gct gac gaa att ttt gcc ggt gcc tgt cca ccc gtg cag gga     1344
 Asp Leu Ala Asp Glu Ile Phe Ala Gly Ala Cys Pro Pro Val Gln Gly
         435                 440                 445

 gag cat gag aaa act gag gct aag agt gaa aag gat ctg tcc aag gac     1392
 Glu His Glu Lys Thr Glu Ala Lys Ser Glu Lys Asp Leu Ser Lys Asp
     450                 455                 460

 aca agt agt aag ctg cga gac tgg ttc agc caa acc cag atg cac gtg     1440
 Thr Ser Ser Lys Leu Arg Asp Trp Phe Ser Gln Thr Gln Met His Val
 465                 470                 475                 480

 cac tca ctg gat acg gag tcc ctg tca gat gat gga gag gct cct tgg     1488
 His Ser Leu Asp Thr Glu Ser Leu Ser Asp Asp Gly Glu Ala Pro Trp
                 485                 490                 495

 gaa ttg ctg cag gag tcc agg ggg tca acg tct gca gct ctc acg ctc     1536
 Glu Leu Leu Gln Glu Ser Arg Gly Ser Thr Ser Ala Ala Leu Thr Leu
             500                 505                 510

 tca gag gtg gct ctg aat ctg ccc atc aag cag ccc atc cac cag ggg     1584
 Ser Glu Val Ala Leu Asn Leu Pro Ile Lys Gln Pro Ile His Gln Gly
         515                 520                 525

 ttc tgg agg cta gac gtc tca gat caa ggt gcc gac agg ttt ggt tct     1632
 Phe Trp Arg Leu Asp Val Ser Asp Gln Gly Ala Asp Arg Phe Gly Ser
     530                 535                 540

 tct gaa ggc cct ttc ctt ggc ctg cag atg gcc atc ttc tca ctg tgt     1680
 Ser Glu Gly Pro Phe Leu Gly Leu Gln Met Ala Ile Phe Ser Leu Cys
 545                 550                 555                 560

 cct ggc ttg gtc ttt cct ctg tgg aag caa agg tgc tca gca gga atg     1728
 Pro Gly Leu Val Phe Pro Leu Trp Lys Gln Arg Cys Ser Ala Gly Met
                 565                 570                 575

 ggg gtt cag aag cgc agg ctg ccc cag gac agg gaa gct gtt gaa ggg     1776
 Gly Val Gln Lys Arg Arg Leu Pro Gln Asp Arg Glu Ala Val Glu Gly
             580                 585                 590

 ttt gct cta gtc cat gaa gtt gcc ttt cct ggc ttt ttc ttt gat gtc     1824
 Phe Ala Leu Val His Glu Val Ala Phe Pro Gly Phe Phe Phe Asp Val
         595                 600                 605

 aaa agc acc agg agg ctg gaa tgc agt ggt gcc atc ata gct cac tgc     1872
 Lys Ser Thr Arg Arg Leu Glu Cys Ser Gly Ala Ile Ile Ala His Cys
     610                 615                 620

 agc ctc ata ctt ctg ggc tcc agc cat cct ccc atc aca gct tcc cga     1920
 Ser Leu Ile Leu Leu Gly Ser Ser His Pro Pro Ile Thr Ala Ser Arg
 625                 630                 635                 640

 gta gct ggg act aca gac ccc tat agc ccg tcg ctg tca gct gtc aac     1968
 Val Ala Gly Thr Thr Asp Pro Tyr Ser Pro Ser Leu Ser Ala Val Asn
                 645                 650                 655

 aaa gga tgc gaa tgc tgg ccg ctt cct gtg ggc ttc gtg tca ccc aga     2016
 Lys Gly Cys Glu Cys Trp Pro Leu Pro Val Gly Phe Val Ser Pro Arg
             660                 665                 670

 gga gag gtg acc aaa gag gac ttg ctg ctc aaa tct aag gtt gcc tgc     2064
 Gly Glu Val Thr Lys Glu Asp Leu Leu Leu Lys Ser Lys Val Ala Cys
         675                 680                 685

 ccc tat gtt ggc tgc gga gaa tcc ttt gct gac cac agc acc att cat     2112
 Pro Tyr Val Gly Cys Gly Glu Ser Phe Ala Asp His Ser Thr Ile His
     690                 695                 700

 gca cag gca aaa aag cac aac ttg acc gtg aac ctg acc acg ttc cga     2160
 Ala Gln Ala Lys Lys His Asn Leu Thr Val Asn Leu Thr Thr Phe Arg
 705                 710                 715                 720

 ctg tgg tgt tac gcc tgt gag aag gag gta ttc ctg gag cag cgg ctg     2208
 Leu Trp Cys Tyr Ala Cys Glu Lys Glu Val Phe Leu Glu Gln Arg Leu
                 725                 730                 735

 gca gcc cct ctg ctg ggc tcc tct tcc aag ttc tct gaa cag gac tcc     2256
 Ala Ala Pro Leu Leu Gly Ser Ser Ser Lys Phe Ser Glu Gln Asp Ser
             740                 745                 750

 ccg cca ccc tcc cac cct ctg aaa gct gtt cct att gct gtg gct gat     2304
 Pro Pro Pro Ser His Pro Leu Lys Ala Val Pro Ile Ala Val Ala Asp
         755                 760                 765

 gaa gga gag tct gag tca gag gac gat gac ctg aaa cct cga ggc ctc     2352
 Glu Gly Glu Ser Glu Ser Glu Asp Asp Asp Leu Lys Pro Arg Gly Leu
     770                 775                 780

 acg ggc atg aag aac ctc ggg aac tcc tgc tac atg aac gct gcc ctg     2400
 Thr Gly Met Lys Asn Leu Gly Asn Ser Cys Tyr Met Asn Ala Ala Leu
 785                 790                 795                 800

 cag gcc ctg tcc aat tgc aag tgc agg aaa aat ggc aca aga caa cat     2448
 Gln Ala Leu Ser Asn Cys Lys Cys Arg Lys Asn Gly Thr Arg Gln His
                 805                 810                 815

 gca ttg aaa caa gaa ggg gtt cag aat ctg ttc ttc ttg gag tgt ggc     2496
 Ala Leu Lys Gln Glu Gly Val Gln Asn Leu Phe Phe Leu Glu Cys Gly
             820                 825                 830

 ggc ctg gtg cgc aca gat aag aag cca gcc ctg tgc aag agc tac cag     2544
 Gly Leu Val Arg Thr Asp Lys Lys Pro Ala Leu Cys Lys Ser Tyr Gln
         835                 840                 845

 aag ctg gtc tct gag gtc tgg cat aag aaa cgg cca agc tac gtg gtc     2592
 Lys Leu Val Ser Glu Val Trp His Lys Lys Arg Pro Ser Tyr Val Val
     850                 855                 860

 ccc acc agt ctg tct cat ggg atc aag ttg gtc aac cca atg ttc cga     2640
 Pro Thr Ser Leu Ser His Gly Ile Lys Leu Val Asn Pro Met Phe Arg
 865                 870                 875                 880

 ggc tat gcc cag cag gac acc caa gag ttc ctt cgc tgc ctg atg gac     2688
 Gly Tyr Ala Gln Gln Asp Thr Gln Glu Phe Leu Arg Cys Leu Met Asp
                 885                 890                 895

 cag ctg cac gag gag ctc aag gag ccg gtg gtg gcc acg gtg gcg ctg     2736
 Gln Leu His Glu Glu Leu Lys Glu Pro Val Val Ala Thr Val Ala Leu
             900                 905                 910

 acg gag gct cgg gac tca gat tcg agt gac acg gat gag aaa cgg gag     2784
 Thr Glu Ala Arg Asp Ser Asp Ser Ser Asp Thr Asp Glu Lys Arg Glu
         915                 920                 925

 ggt gac cgg agc cca tca gaa gat gag ttc ttg tcc tgt gac tcg agc     2832
 Gly Asp Arg Ser Pro Ser Glu Asp Glu Phe Leu Ser Cys Asp Ser Ser
     930                 935                 940

 agt gac cgg ggt gag ggt gac ggg cag ggg cgt ggc ggg ggc agc tcg     2880
 Ser Asp Arg Gly Glu Gly Asp Gly Gln Gly Arg Gly Gly Gly Ser Ser
 945                 950                 955                 960

 cag gcc gag acg gag ctg ctg atc cca gat gag gcg ggc cga gcc atc     2928
 Gln Ala Glu Thr Glu Leu Leu Ile Pro Asp Glu Ala Gly Arg Ala Ile
                 965                 970                 975

 tct gag aag gag cgg atg aag gac cgc aag ttc tcc tgg ggc cag cag     2976
 Ser Glu Lys Glu Arg Met Lys Asp Arg Lys Phe Ser Trp Gly Gln Gln
             980                 985                 990

 cgt aca aac tcg gag caa gtg gac gag gac gct gat gtg gac act gcc     3024
 Arg Thr Asn Ser Glu Gln Val Asp Glu Asp Ala Asp Val Asp Thr Ala
         995                1000                1005

 atg gct gcc ctt gac gac cag ccc gcg gag gcc cag ccc ccg tca cca     3072
 Met Ala Ala Leu Asp Asp Gln Pro Ala Glu Ala Gln Pro Pro Ser Pro
    1010                1015                1020

 cgg tcc tcc agc ccc tgc cgg acg cca gag ccg gac aat gat gct cac     3120
 Arg Ser Ser Ser Pro Cys Arg Thr Pro Glu Pro Asp Asn Asp Ala His
1025                1030                1035                1040

 cta cgc agc tcc tct cgc ccc tgc agc ccc gtc cac cac cac gag ggc     3168
 Leu Arg Ser Ser Ser Arg Pro Cys Ser Pro Val His His His Glu Gly
                1045                1050                1055

 cat gcc aag ctg tct agc agc ccc cct cgt gca agc ccc gtg agg atg     3216
 His Ala Lys Leu Ser Ser Ser Pro Pro Arg Ala Ser Pro Val Arg Met
            1060                1065                1070

 gca ccg tcg tac gtg ctc aag aaa gcc cag gta ttg agt gct ggc agc     3264
 Ala Pro Ser Tyr Val Leu Lys Lys Ala Gln Val Leu Ser Ala Gly Ser
        1075                1080                1085

 cgg agg cgg aag gag cag cgc tac cgc agc gtc atc tca gac atc ttt     3312
 Arg Arg Arg Lys Glu Gln Arg Tyr Arg Ser Val Ile Ser Asp Ile Phe
    1090                1095                1100

 gac ggc tcc att ctc agc ctt gtg cag tgt ctc acc tgt gac cgg gta     3360
 Asp Gly Ser Ile Leu Ser Leu Val Gln Cys Leu Thr Cys Asp Arg Val
1105                1110                1115                1120

 tcc acc aca gtg gaa acg ttc cag gac tta tca ctg ccc att cct gga     3408
 Ser Thr Thr Val Glu Thr Phe Gln Asp Leu Ser Leu Pro Ile Pro Gly
                1125                1130                1135

 aag gag gac ctg gcc aag ctc cat tca gcc atc tac cag aat gtg ccg     3456
 Lys Glu Asp Leu Ala Lys Leu His Ser Ala Ile Tyr Gln Asn Val Pro
            1140                1145                1150

 gcc aag cca ggc gcc tgt ggg gac agc tat gcc gcc cag ggc tgg ctg     3504
 Ala Lys Pro Gly Ala Cys Gly Asp Ser Tyr Ala Ala Gln Gly Trp Leu
        1155                1160                1165

 gcc ttc att gtg gag tac atc cga cgg ttt gtg gta tcc tgt acc ccc     3552
 Ala Phe Ile Val Glu Tyr Ile Arg Arg Phe Val Val Ser Cys Thr Pro
    1170                1175                1180

 agc tgg ttt tgg ggg cct gtc gtc acc ctg gaa gac tgc ctt gct gcc     3600
 Ser Trp Phe Trp Gly Pro Val Val Thr Leu Glu Asp Cys Leu Ala Ala
1185                1190                1195                1200

 ttc ttt gcc gct gat gag tta aag ggt gac aac atg tac agc tgt gag     3648
 Phe Phe Ala Ala Asp Glu Leu Lys Gly Asp Asn Met Tyr Ser Cys Glu
                1205                1210                1215

 cgg tgt aag aag ctg cgg aac gga gtg aag tac tgc aaa gtc ctg cgg     3696
 Arg Cys Lys Lys Leu Arg Asn Gly Val Lys Tyr Cys Lys Val Leu Arg
            1220                1225                1230

 ttg ccc gag atc ctg tgc att cac cta aag cgc ttt cgg cac gag gtg     3744
 Leu Pro Glu Ile Leu Cys Ile His Leu Lys Arg Phe Arg His Glu Val
        1235                1240                1245

 atg tac tca ttc aag atc aac agc cac gtc tcc ttc ccc ctc gag ggg     3792
 Met Tyr Ser Phe Lys Ile Asn Ser His Val Ser Phe Pro Leu Glu Gly
    1250                1255                1260

 ctc gac ctg cgc ccc ttc ctt gcc aag gag tgc aca tcc cag atc acc     3840
 Leu Asp Leu Arg Pro Phe Leu Ala Lys Glu Cys Thr Ser Gln Ile Thr
1265                1270                1275                1280

 acc tac gac ctc ctc tcg gtc atc tgc cac cac ggc acg gca ggc agt     3888
 Thr Tyr Asp Leu Leu Ser Val Ile Cys His His Gly Thr Ala Gly Ser
                1285                1290                1295

 ggg cac tac atc gcc tac tgc cag aac gtg atc aat ggg cag tgg tac     3936
 Gly His Tyr Ile Ala Tyr Cys Gln Asn Val Ile Asn Gly Gln Trp Tyr
            1300                1305                1310

 gag ttt gat gac cag tac gtc aca gaa gtc cac gag acg gtg gtg cag     3984
 Glu Phe Asp Asp Gln Tyr Val Thr Glu Val His Glu Thr Val Val Gln
        1315                1320                1325

 aac gcc gag ggc tac gta ctc ttc tac agg aag agc agc gag gag gcc     4032
 Asn Ala Glu Gly Tyr Val Leu Phe Tyr Arg Lys Ser Ser Glu Glu Ala
    1330                1335                1340

 atg cgg gag cga cag cag gtg gtg tcc ctg gcc gcc atg cgg gag ccc     4080
 Met Arg Glu Arg Gln Gln Val Val Ser Leu Ala Ala Met Arg Glu Pro
1345                1350                1355                1360

 agc ctg ctg cgg ttc tac gtg tcc cgc gag tgg ctc aac aag ttc aac     4128
 Ser Leu Leu Arg Phe Tyr Val Ser Arg Glu Trp Leu Asn Lys Phe Asn
                1365                1370                1375

 acc ttc gcg gag cca ggc ccc atc acc aac cag acc ttc ctc tgc tcc     4176
 Thr Phe Ala Glu Pro Gly Pro Ile Thr Asn Gln Thr Phe Leu Cys Ser
            1380                1385                1390

 cac gga ggc atc ccg ccc cac aaa tac cac tac atc gac gac ctg gtg     4224
 His Gly Gly Ile Pro Pro His Lys Tyr His Tyr Ile Asp Asp Leu Val
        1395                1400                1405

 gtc atc ctg ccc cag aac gtc tgg gag cac ctg tac aac aga ttc ggg     4272
 Val Ile Leu Pro Gln Asn Val Trp Glu His Leu Tyr Asn Arg Phe Gly
    1410                1415                1420

 ggt ggc ccc gcc gtg aac cac ctg tac gtg tgc tcc atc tgc cag gtg     4320
 Gly Gly Pro Ala Val Asn His Leu Tyr Val Cys Ser Ile Cys Gln Val
1425                1430                1435                1440

 gag atc gag gca ctg gcc aag cgc agg agg atc gag atc gac acc ttc     4368
 Glu Ile Glu Ala Leu Ala Lys Arg Arg Arg Ile Glu Ile Asp Thr Phe
                1445                1450                1455

 atc aag ttg aac aag gcc ttc cag gcc gag gag tcg ccg ggc gtc atc     4416
 Ile Lys Leu Asn Lys Ala Phe Gln Ala Glu Glu Ser Pro Gly Val Ile
            1460                1465                1470

 tac tgc atc agc atg cag tgg ttc cgg gag tgg gag gcg ttc gtc aag     4464
 Tyr Cys Ile Ser Met Gln Trp Phe Arg Glu Trp Glu Ala Phe Val Lys
        1475                1480                1485

 ggg aag gac aac gag ccc ccc ggg ccc att gac aac agc agg att gca     4512
 Gly Lys Asp Asn Glu Pro Pro Gly Pro Ile Asp Asn Ser Arg Ile Ala
    1490                1495                1500

 cag gtc aaa gga agc ggc cat gtc cag ctg aag cag gga gct gac tac     4560
 Gln Val Lys Gly Ser Gly His Val Gln Leu Lys Gln Gly Ala Asp Tyr
1505                1510                1515                1520

 ggg cag att tcg gag gag acc tgg acc tac ctg aac agc ctg tat gga     4608
 Gly Gln Ile Ser Glu Glu Thr Trp Thr Tyr Leu Asn Ser Leu Tyr Gly
                1525                1530                1535

 ggt ggc ccc gag att gcc atc cgc cag agt gtg gcg cag ccg ctg ggc     4656
 Gly Gly Pro Glu Ile Ala Ile Arg Gln Ser Val Ala Gln Pro Leu Gly
            1540                1545                1550

 cca gag aac ctg cac ggg gag cag aag atc gaa gcc gag acg cgg gcc     4704
 Pro Glu Asn Leu His Gly Glu Gln Lys Ile Glu Ala Glu Thr Arg Ala
        1555                1560                1565

 gaa aaa ggg gtt ccg atc cag acc cct aga gaa ggt tct tgg atc tca     4752
 Glu Lys Gly Val Pro Ile Gln Thr Pro Arg Glu Gly Ser Trp Ile Ser
    1570                1575                1580

 tgc agg aag aaa ctc aag gct tct gct tcc ctg ccg cta tca gat acg     4800
 Cys Arg Lys Lys Leu Lys Ala Ser Ala Ser Leu Pro Leu Ser Asp Thr
1585                1590                1595                1600

 agc gta cag aaa cat ttc agc gta tgc aag gat aac acg gtg aca agg     4848
 Ser Val Gln Lys His Phe Ser Val Cys Lys Asp Asn Thr Val Thr Arg
                1605                1610                1615

 aac caa gat gac aca ttg cca gtt cca tgg aaa gcc tgg ggc ccc tcc     4896
 Asn Gln Asp Asp Thr Leu Pro Val Pro Trp Lys Ala Trp Gly Pro Ser
            1620                1625                1630

 gga gtc ggc cac ctt gcc tga                                         4917
 Gly Val Gly His Leu Ala 
        1635





      <210> 895
      <211> 1617
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (1)..(1617)

      <400> 895
  atg ggg gta ccc tgg cgc ctg gca ccc ctg ggc cag ggc ctg tcc aca      48
  Met Gly Val Pro Trp Arg Leu Ala Pro Leu Gly Gln Gly Leu Ser Thr
    1               5                  10                  15

 gtc tgg ctg ccg tcc aag atg gcc ctg gtg gaa acc ccc cag agc ccc       96
 Val Trp Leu Pro Ser Lys Met Ala Leu Val Glu Thr Pro Gln Ser Pro
              20                  25                  30

 tcc ttc cat gcc ccc caa cac ttt gta tct gtt gta ctc cag ctc cag      144
 Ser Phe His Ala Pro Gln His Phe Val Ser Val Val Leu Gln Leu Gln
          35                  40                  45

 gct tgc gtc cac ctc ccc gag ggc acg cag aac tac ttt gag agc tac      192
 Ala Cys Val His Leu Pro Glu Gly Thr Gln Asn Tyr Phe Glu Ser Tyr
      50                  55                  60

 ctt gcc gtt gcc tcc acc gtg ccc tcc atg ctg tgc ctg gtg gcc aac      240
 Leu Ala Val Ala Ser Thr Val Pro Ser Met Leu Cys Leu Val Ala Asn
  65                  70                  75                  80

 ttc ctg ctt gtc aac agg gtt gca gtc cac atc cgt gtc ctg gcc tca      288
 Phe Leu Leu Val Asn Arg Val Ala Val His Ile Arg Val Leu Ala Ser
                  85                  90                  95

 ctg acg gtc atc ctg gcc atc ttc atg gtg ata act gca ctg gtg aag      336
 Leu Thr Val Ile Leu Ala Ile Phe Met Val Ile Thr Ala Leu Val Lys
             100                 105                 110

 gtg gac act tcc tcc tgg acc cgt ggc ttt ttt gcg gtc acc att gtc      384
 Val Asp Thr Ser Ser Trp Thr Arg Gly Phe Phe Ala Val Thr Ile Val
         115                 120                 125

 tgc atg gtg atc ctc agc ggt gcc tcc act gtc ttc agc agc agc atc      432
 Cys Met Val Ile Leu Ser Gly Ala Ser Thr Val Phe Ser Ser Ser Ile
     130                 135                 140

 tac ggc atg acc ggc tcc ttt cct atg agg aac tcc cag gca ctg ata      480
 Tyr Gly Met Thr Gly Ser Phe Pro Met Arg Asn Ser Gln Ala Leu Ile
 145                 150                 155                 160

 tca gga gga gcc atg ggc ggg acg gtc agc gcc gtg gcc tca ttg gtg      528
 Ser Gly Gly Ala Met Gly Gly Thr Val Ser Ala Val Ala Ser Leu Val
                 165                 170                 175

 gac ttg gct gca tcc agt gat gtg agg aac agc gcc ctg gcc ttc ttc      576
 Asp Leu Ala Ala Ser Ser Asp Val Arg Asn Ser Ala Leu Ala Phe Phe
             180                 185                 190

 ctg acg gcc act gtc ttc ctc gtg ctc tgc atg gga ctc tac ctg ctg      624
 Leu Thr Ala Thr Val Phe Leu Val Leu Cys Met Gly Leu Tyr Leu Leu
         195                 200                 205

 ctg tcc agg ctg gag tat gcc agg tac tac atg agg cct gtt ctt gcg      672
 Leu Ser Arg Leu Glu Tyr Ala Arg Tyr Tyr Met Arg Pro Val Leu Ala
     210                 215                 220

 gcc cat gtg ttt tct ggt gaa gag gag ctt ccc cag gac tcc ctc agt      720
 Ala His Val Phe Ser Gly Glu Glu Glu Leu Pro Gln Asp Ser Leu Ser
 225                 230                 235                 240

 gcc cct tcg gtg gcc tcc aga ttc att gat tcc cac aca ccc cct ctc      768
 Ala Pro Ser Val Ala Ser Arg Phe Ile Asp Ser His Thr Pro Pro Leu
                 245                 250                 255

 cgc ccc atc ctg aag aag acg gcc agc ctg ggc ttc tgt gtc acc tac      816
 Arg Pro Ile Leu Lys Lys Thr Ala Ser Leu Gly Phe Cys Val Thr Tyr
             260                 265                 270

 gtc ttc ttc atc acc agc ctc atc tac ccc gcc gtc tgc acc aac atc      864
 Val Phe Phe Ile Thr Ser Leu Ile Tyr Pro Ala Val Cys Thr Asn Ile
         275                 280                 285

 gag tcc ctc aac aag ggc tcg ggc tca ctg tgg acc acc aag ttt ttc      912
 Glu Ser Leu Asn Lys Gly Ser Gly Ser Leu Trp Thr Thr Lys Phe Phe
     290                 295                 300

 atc ccc ctc act acc ttc ctc ctg tac aac ttt gct gac cta tgt ggc      960
 Ile Pro Leu Thr Thr Phe Leu Leu Tyr Asn Phe Ala Asp Leu Cys Gly
 305                 310                 315                 320

 cgg cag ctc acc gcc tgg atc cag gtg cca ggg ccc aat agc aag gcg     1008
 Arg Gln Leu Thr Ala Trp Ile Gln Val Pro Gly Pro Asn Ser Lys Ala
                 325                 330                 335

 ctc cca ggg ttc gtg ctc ctc cgg acc tgc ctc atc ccc ctc ttc gtg     1056
 Leu Pro Gly Phe Val Leu Leu Arg Thr Cys Leu Ile Pro Leu Phe Val
             340                 345                 350

 ctc tgt aac tac cag ccc cgc gtc cac ctg aag act gtg gtc ttc cag     1104
 Leu Cys Asn Tyr Gln Pro Arg Val His Leu Lys Thr Val Val Phe Gln
         355                 360                 365

 tcc gat gtg tac ccc gca ctc ctc agc tcc ctg ctg ggg ctc agc aac     1152
 Ser Asp Val Tyr Pro Ala Leu Leu Ser Ser Leu Leu Gly Leu Ser Asn
     370                 375                 380

 ggc tac ctc agc acc ctg gcc ctc ctc tac ggg cct aag att gtg ccc     1200
 Gly Tyr Leu Ser Thr Leu Ala Leu Leu Tyr Gly Pro Lys Ile Val Pro
 385                 390                 395                 400

 agg gag ctg gct gag gcc acg gga gtg ccc ttc aaa gat gct gcc agt     1248
 Arg Glu Leu Ala Glu Ala Thr Gly Val Pro Phe Lys Asp Ala Ala Ser
                 405                 410                 415

 gtt cgc cct aga gtt att aca aag cca gtg cca aaa ccc agc cat ggg     1296
 Val Arg Pro Arg Val Ile Thr Lys Pro Val Pro Lys Pro Ser His Gly
             420                 425                 430

 ctc ttt gca acc tcc cag ctg cgc tca ttc cag ctg aca gcg aga tgc     1344
 Leu Phe Ala Thr Ser Gln Leu Arg Ser Phe Gln Leu Thr Ala Arg Cys
         435                 440                 445

 aag caa atg ctc agc tct cct tac cct gaa ggg gtc tcc ctg gaa tgg     1392
 Lys Gln Met Leu Ser Ser Pro Tyr Pro Glu Gly Val Ser Leu Glu Trp
     450                 455                 460

 aag tcc cct ggc atg atc cat ttg cac ccc atc cta tgg gac aag gag     1440
 Lys Ser Pro Gly Met Ile His Leu His Pro Ile Leu Trp Asp Lys Glu
 465                 470                 475                 480

 tct gta gga cca aag gga cat gat aac cag gag ctc aca gcc ctc ttc     1488
 Ser Val Gly Pro Lys Gly His Asp Asn Gln Glu Leu Thr Ala Leu Phe
                 485                 490                 495

 cct tct gcc atg ctc tgg ggt gca ggt cct cag ctg gca gcg gga gaa     1536
 Pro Ser Ala Met Leu Trp Gly Ala Gly Pro Gln Leu Ala Ala Gly Glu
             500                 505                 510

 agg cag ctg gtg aaa ggc agc agc cag cga ctt cac cac ttt gag ttg     1584
 Arg Gln Leu Val Lys Gly Ser Ser Gln Arg Leu His His Phe Glu Leu
         515                 520                 525

 ggc ccc ttc tgg tgt aga acc tgg atc ccc taa                         1617
 Gly Pro Phe Trp Cys Arg Thr Trp Ile Pro 
     530                 535





      <210> 896
      <211> 804
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (1)..(804)

      <220>
      <221> misc_feature
      <222> (1)...(804)
      <223> n = a,t,c or g

      <400> 896
  atg ggg acc aat ccg cct gca ggc agt aga gga gga atc agg ttt agc      48
  Met Gly Thr Asn Pro Pro Ala Gly Ser Arg Gly Gly Ile Arg Phe Ser
    1               5                  10                  15

 cac agc aag aga gaa act gag ttc ctt acc ctc tgc cat atc agg atg       96
 His Ser Lys Arg Glu Thr Glu Phe Leu Thr Leu Cys His Ile Arg Met
              20                  25                  30

 ctc ctt ggt ttg ggg tct aca tgt aac ttg gca atg act gtt tgt ttt      144
 Leu Leu Gly Leu Gly Ser Thr Cys Asn Leu Ala Met Thr Val Cys Phe
          35                  40                  45

 ttc tcg gat gtg ctg ggt ggc gtc ctg atc acc gca ctc ctc atc gtc      192
 Phe Ser Asp Val Leu Gly Gly Val Leu Ile Thr Ala Leu Leu Ile Val
      50                  55                  60

 ctc acc tac cct gcc tgg acc ttc atc gac tgc ctg gac tcg gcc agc      240
 Leu Thr Tyr Pro Ala Trp Thr Phe Ile Asp Cys Leu Asp Ser Ala Ser
  65                  70                  75                  80

 ccc ctc ttc ccc gtg tgt gtc ata gtt gtg cca ttc ttc ctg tgt tac      288
 Pro Leu Phe Pro Val Cys Val Ile Val Val Pro Phe Phe Leu Cys Tyr
                  85                  90                  95

 aat tac cct gtt tct gat tac tac agc cca acc cgg gcg gac acc acc      336
 Asn Tyr Pro Val Ser Asp Tyr Tyr Ser Pro Thr Arg Ala Asp Thr Thr
             100                 105                 110

 acc att ctg gct gcc ggg gct gga gtg acc ata gga ttc tgg atc aac      384
 Thr Ile Leu Ala Ala Gly Ala Gly Val Thr Ile Gly Phe Trp Ile Asn
         115                 120                 125

 cat ttc ttc cag ctt gta tcc aag ccc gct gaa tct ctc cct gtt att      432
 His Phe Phe Gln Leu Val Ser Lys Pro Ala Glu Ser Leu Pro Val Ile
     130                 135                 140

 cag aac atc cca cca ctc acc acc tac atg tta gtt ttg ggt ctg acc      480
 Gln Asn Ile Pro Pro Leu Thr Thr Tyr Met Leu Val Leu Gly Leu Thr
 145                 150                 155                 160

 aaa ttt gca gtg gga att gtg ttg atc ctc ttg gtt cgt cag ctt gta      528
 Lys Phe Ala Val Gly Ile Val Leu Ile Leu Leu Val Arg Gln Leu Val
                 165                 170                 175

 caa aag ggg tat tct naa aag ggg aat aaa aca tct cca gtg ttc cat      576
 Gln Lys Gly Tyr Ser XXX Lys Gly Asn Lys Thr Ser Pro Val Phe His
             180                 185                 190

 act ggg gtg aaa ttg aca gga gaa tca aga ctt tcc aac tat agg ttt      624
 Thr Gly Val Lys Leu Thr Gly Glu Ser Arg Leu Ser Asn Tyr Arg Phe
         195                 200                 205

 atc tnt acc caa tat cca ttt gtg ttg gga ctg gtg atg gcc gtg gtg      672
 Ile XXX Thr Gln Tyr Pro Phe Val Leu Gly Leu Val Met Ala Val Val
     210                 215                 220

 ttt tcc acc ttg gtg tgt ctc agc agg ctc tac act ggg atg cat acg      720
 Phe Ser Thr Leu Val Cys Leu Ser Arg Leu Tyr Thr Gly Met His Thr
 225                 230                 235                 240

 gtc ctg ctg tgt gac tca ggg cag atc att tca cct tct ctg aac ncc      768
 Val Leu Leu Cys Asp Ser Gly Gln Ile Ile Ser Pro Ser Leu Asn XXX
                 245                 250                 255

 aag ctc nnt gtt gtg agg gtc aaa tgg gag cat tga                      804
 Lys Leu XXX Val Val Arg Val Lys Trp Glu His 
             260                 265





      <210> 897
      <211> 375
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (1)..(375)

      <220>
      <221> misc_feature
      <222> (1)...(375)
      <223> n = a,t,c or g

      <400> 897
  atg gag agc gct ctc ccc gcc gcc ggc ttc ctg tac tgg gtc ggc gcg      48
  Met Glu Ser Ala Leu Pro Ala Ala Gly Phe Leu Tyr Trp Val Gly Ala
    1               5                  10                  15

 ggc acc gtg gcc tac cta gcc ctg cgt att tcg tac tcg ctc ttc acg       96
 Gly Thr Val Ala Tyr Leu Ala Leu Arg Ile Ser Tyr Ser Leu Phe Thr
              20                  25                  30

 gcc ctc cgg gtc tgg gga gtg ggg aat gag gcn ggg ggt cgg ccc ggg      144
 Ala Leu Arg Val Trp Gly Val Gly Asn Glu XXX Gly Gly Arg Pro Gly
          35                  40                  45

 gct cgg aga atg ggc agg ctc ctg tgc ccc gcg ggc ccc tcc tgg ctc      192
 Ala Arg Arg Met Gly Arg Leu Leu Cys Pro Ala Gly Pro Ser Trp Leu
      50                  55                  60

 cct tgg ctg tct tct gct tgc tta gac tac ttg cag agt ttt aag gga      240
 Pro Trp Leu Ser Ser Ala Cys Leu Asp Tyr Leu Gln Ser Phe Lys Gly
  65                  70                  75                  80

 ctg agt gat ggg gtt att gaa aca ctg aaa cta ggt tat tgc gtt gtc      288
 Leu Ser Asp Gly Val Ile Glu Thr Leu Lys Leu Gly Tyr Cys Val Val
                  85                  90                  95

 atg cgt gtt ctg gac ttc ctt att ttt gct aat tat gtc atc gtc ttg      336
 Met Arg Val Leu Asp Phe Leu Ile Phe Ala Asn Tyr Val Ile Val Leu
             100                 105                 110

 cta gtc atg aag ctc caa atc aga gat ggc aaa ttc tga                  375
 Leu Val Met Lys Leu Gln Ile Arg Asp Gly Lys Phe 
         115                 120





      <210> 898
      <211> 681
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (1)..(681)

      <400> 898
  atg agg aat ctg agg cta aaa gag ttg ccc aaa tgg ttt aag atg cta      48
  Met Arg Asn Leu Arg Leu Lys Glu Leu Pro Lys Trp Phe Lys Met Leu
    1               5                  10                  15

 aag ctc ttt agt tta att aga tat cat gtg tca att ttg gct tta gtt       96
 Lys Leu Phe Ser Leu Ile Arg Tyr His Val Ser Ile Leu Ala Leu Val
              20                  25                  30

 gca att gct ttt ggc gtt ttt gtc atg aag gct ttg ccc gtg cct gac      144
 Ala Ile Ala Phe Gly Val Phe Val Met Lys Ala Leu Pro Val Pro Asp
          35                  40                  45

 cat tat aag caa att aat aac cac aca gcc aaa atg cat gaa cac aac      192
 His Tyr Lys Gln Ile Asn Asn His Thr Ala Lys Met His Glu His Asn
      50                  55                  60

 atg aag ctt gta tgt gat cag aat gga gat att gga aaa cag gga aag      240
 Met Lys Leu Val Cys Asp Gln Asn Gly Asp Ile Gly Lys Gln Gly Lys
  65                  70                  75                  80

 tta gcg agc tgc ata gaa att ggc cca gtg aca att acc aca gat ccc      288
 Leu Ala Ser Cys Ile Glu Ile Gly Pro Val Thr Ile Thr Thr Asp Pro
                  85                  90                  95

 aag aaa ttt caa tat gaa ctc aga gaa ctg tat gtt cag aga tat gga      336
 Lys Lys Phe Gln Tyr Glu Leu Arg Glu Leu Tyr Val Gln Arg Tyr Gly
             100                 105                 110

 att aac ggt ggt ggt gat tgc cca gaa atg agt att gga gct ata aaa      384
 Ile Asn Gly Gly Gly Asp Cys Pro Glu Met Ser Ile Gly Ala Ile Lys
         115                 120                 125

 att gcc ttg gaa att tct ctt cct ggt tct ttc atc tat gtt ttc act      432
 Ile Ala Leu Glu Ile Ser Leu Pro Gly Ser Phe Ile Tyr Val Phe Thr
     130                 135                 140

 gat gct cgg tcc aaa gat tac cgg ctc acc cat gag gtg ctg caa ctt      480
 Asp Ala Arg Ser Lys Asp Tyr Arg Leu Thr His Glu Val Leu Gln Leu
 145                 150                 155                 160

 atc caa cag aaa cag tca caa gtc gta ttt gtt ctg act gga gat tgt      528
 Ile Gln Gln Lys Gln Ser Gln Val Val Phe Val Leu Thr Gly Asp Cys
                 165                 170                 175

 gat gac agg acc cat att gga tat aaa gtc tat gaa gaa att gcc tct      576
 Asp Asp Arg Thr His Ile Gly Tyr Lys Val Tyr Glu Glu Ile Ala Ser
             180                 185                 190

 aca agt tct ggt caa gtg ttc cat ctg gac aaa aaa caa gtt aat gag      624
 Thr Ser Ser Gly Gln Val Phe His Leu Asp Lys Lys Gln Val Asn Glu
         195                 200                 205

 gtc agt tta ata aag gga gtc tac ttt att acc agc tgc ctt atc aaa      672
 Val Ser Leu Ile Lys Gly Val Tyr Phe Ile Thr Ser Cys Leu Ile Lys
     210                 215                 220

 atc agt tag                                                          681
 Ile Ser 
 225





      <210> 899
      <211> 3498
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (1)..(3498)

      <400> 899
  atg agc ctt ctg gca ttg tgg gtt ccc cca cgc tcc agc gcc gga ggg      48
  Met Ser Leu Leu Ala Leu Trp Val Pro Pro Arg Ser Ser Ala Gly Gly
    1               5                  10                  15

 gac cca ggc ggc acc agc gcg tta ggc tgc ccc cgg gag cag tgc tgc       96
 Asp Pro Gly Gly Thr Ser Ala Leu Gly Cys Pro Arg Glu Gln Cys Cys
              20                  25                  30

 agg agc ccc gag ctc gag gtg gtg ccg gca gcc gcg cgc tca gag ctc      144
 Arg Ser Pro Glu Leu Glu Val Val Pro Ala Ala Ala Arg Ser Glu Leu
          35                  40                  45

 caa cag ggc tgg gcc gcg gcc aag gag cca gga ggg tgc acg aga acg      192
 Gln Gln Gly Trp Ala Ala Ala Lys Glu Pro Gly Gly Cys Thr Arg Thr
      50                  55                  60

 tcc cat cca ggg acc cac gga tac ttc gtt cct gcc agg gtc tcc ttt      240
 Ser His Pro Gly Thr His Gly Tyr Phe Val Pro Ala Arg Val Ser Phe
  65                  70                  75                  80

 ggg ccg aca gag ttg tct cta att gag tgc agg cag ccc cgg agc ccg      288
 Gly Pro Thr Glu Leu Ser Leu Ile Glu Cys Arg Gln Pro Arg Ser Pro
                  85                  90                  95

 ccg aga gct gag gct ggg ctg ggc tcc cgg gga ctc ggg cag cta ttt      336
 Pro Arg Ala Glu Ala Gly Leu Gly Ser Arg Gly Leu Gly Gln Leu Phe
             100                 105                 110

 cag gca gac gcg ggg cat cgc gcc cca atg cgc aca gtg ttg ccg agg      384
 Gln Ala Asp Ala Gly His Arg Ala Pro Met Arg Thr Val Leu Pro Arg
         115                 120                 125

 ggc aga aag aga ggg tct cag cct aag cca ggt gga agg tcc gag aag      432
 Gly Arg Lys Arg Gly Ser Gln Pro Lys Pro Gly Gly Arg Ser Glu Lys
     130                 135                 140

 agg ctg gaa ggg ggc gat ggt cca gca gga gct ggg atg aac aag ggc      480
 Arg Leu Glu Gly Gly Asp Gly Pro Ala Gly Ala Gly Met Asn Lys Gly
 145                 150                 155                 160

 tgg aag agc agg cgt gtg ccc agc tta gat cca cct gca gct ggc tct      528
 Trp Lys Ser Arg Arg Val Pro Ser Leu Asp Pro Pro Ala Ala Gly Ser
                 165                 170                 175

 gaa cgc tgg atg ggg ctg ggt tgg ggt ttt cct gtg gcc tgg ggg tct      576
 Glu Arg Trp Met Gly Leu Gly Trp Gly Phe Pro Val Ala Trp Gly Ser
             180                 185                 190

 ctg atg acc ttg agg ttg ctg ttc act cac ctc ctc acc cct ggt ctt      624
 Leu Met Thr Leu Arg Leu Leu Phe Thr His Leu Leu Thr Pro Gly Leu
         195                 200                 205

 atg tat cac acc aaa gtg tca gct gtg caa aag cca gga ata gga ttc      672
 Met Tyr His Thr Lys Val Ser Ala Val Gln Lys Pro Gly Ile Gly Phe
     210                 215                 220

 cta ctc tgt agg gac ccc tgt ggc tgg cgc aga gag gcc ctg ccc aga      720
 Leu Leu Cys Arg Asp Pro Cys Gly Trp Arg Arg Glu Ala Leu Pro Arg
 225                 230                 235                 240

 gag gag gaa tct aga gag gca gtc tgg cta cag tgg ctt tac caa gct      768
 Glu Glu Glu Ser Arg Glu Ala Val Trp Leu Gln Trp Leu Tyr Gln Ala
                 245                 250                 255

 ttg gtg agc tct gtc cag ttc aaa ctt ccc aga ggc ttt gtt tac acg      816
 Leu Val Ser Ser Val Gln Phe Lys Leu Pro Arg Gly Phe Val Tyr Thr
             260                 265                 270

 gtg agg ggg aaa acc acc tac tca agc ctc agt aat gat gga cac ccc      864
 Val Arg Gly Lys Thr Thr Tyr Ser Ser Leu Ser Asn Asp Gly His Pro
         275                 280                 285

 tcc ccc acc aag ctc gag tgt ccc agg tcg att tca gac tgc tgt gcc      912
 Ser Pro Thr Lys Leu Glu Cys Pro Arg Ser Ile Ser Asp Cys Cys Ala
     290                 295                 300

 ggc agc aag att ttc aag cca gtg gat ctt agc ttg ctg ggc tcc ata      960
 Gly Ser Lys Ile Phe Lys Pro Val Asp Leu Ser Leu Leu Gly Ser Ile
 305                 310                 315                 320

 ggg agc cct cca gat ccc atg cat aga gca gct gct gcc acc agc agc     1008
 Gly Ser Pro Pro Asp Pro Met His Arg Ala Ala Ala Ala Thr Ser Ser
                 325                 330                 335

 aca gac atc ttc caa ggg ctg gca gag cca ggg cac ctg ctc tcc aag     1056
 Thr Asp Ile Phe Gln Gly Leu Ala Glu Pro Gly His Leu Leu Ser Lys
             340                 345                 350

 aag ggc aga ggt cgg cag gca tgc aca gca ctt acc cca agg cat ggt     1104
 Lys Gly Arg Gly Arg Gln Ala Cys Thr Ala Leu Thr Pro Arg His Gly
         355                 360                 365

 gtc att att gct gtt gct ttg gag cct ctt atg gga ctg gaa tct gtg     1152
 Val Ile Ile Ala Val Ala Leu Glu Pro Leu Met Gly Leu Glu Ser Val
     370                 375                 380

 gag agg atg gag aga aag gtg acc agc aat aca tgt cag agt gta caa     1200
 Glu Arg Met Glu Arg Lys Val Thr Ser Asn Thr Cys Gln Ser Val Gln
 385                 390                 395                 400

 tta gaa aaa aaa ata caa aca ata cat tat gtt gtg gtt ctc aaa cgt     1248
 Leu Glu Lys Lys Ile Gln Thr Ile His Tyr Val Val Val Leu Lys Arg
                 405                 410                 415

 gag tgt gca tca gaa tcc cct gga gaa gtg tat tca aac aca gat ttc     1296
 Glu Cys Ala Ser Glu Ser Pro Gly Glu Val Tyr Ser Asn Thr Asp Phe
             420                 425                 430

 tgg gac cca ccc cta gaa att ttg act cag tgt gcc cga ggt gga tcc     1344
 Trp Asp Pro Pro Leu Glu Ile Leu Thr Gln Cys Ala Arg Gly Gly Ser
         435                 440                 445

 caa gaa ttt gca ttt ctg tgg aag gga aac cct ggt agt gcc agg ttt     1392
 Gln Glu Phe Ala Phe Leu Trp Lys Gly Asn Pro Gly Ser Ala Arg Phe
     450                 455                 460

 atg gct gca ggg ctg aga gca aca aaa ccc atc cag gca gca gga cct     1440
 Met Ala Ala Gly Leu Arg Ala Thr Lys Pro Ile Gln Ala Ala Gly Pro
 465                 470                 475                 480

 gct ggt tgg gct gac agc ctt gga gac tgt gtt gaa cct gat agg aac     1488
 Ala Gly Trp Ala Asp Ser Leu Gly Asp Cys Val Glu Pro Asp Arg Asn
                 485                 490                 495

 aca aga gtc aac aat gtt gga aaa tcg cca gag gac aca gac ctg gga     1536
 Thr Arg Val Asn Asn Val Gly Lys Ser Pro Glu Asp Thr Asp Leu Gly
             500                 505                 510

 gcg gcc aag tca aga cat cca ggc tgt ctg gct cca gaa cta gga ctc     1584
 Ala Ala Lys Ser Arg His Pro Gly Cys Leu Ala Pro Glu Leu Gly Leu
         515                 520                 525

 gtc ttt gcc aag aga acc cag aac ata ttt aga acc ttt cat ctt ctt     1632
 Val Phe Ala Lys Arg Thr Gln Asn Ile Phe Arg Thr Phe His Leu Leu
     530                 535                 540

 ctc gtc ttt aga cag tct cag tta ttt aga gaa att gta aac att tta     1680
 Leu Val Phe Arg Gln Ser Gln Leu Phe Arg Glu Ile Val Asn Ile Leu
 545                 550                 555                 560

 aga tgc gta act gca agc ctt cac tac aaa gaa ata aaa cag cct gga     1728
 Arg Cys Val Thr Ala Ser Leu His Tyr Lys Glu Ile Lys Gln Pro Gly
                 565                 570                 575

 gag aga ggg gct gac ttt gac ctt gtc tgt gtc aat gcg tgg atg ctg     1776
 Glu Arg Gly Ala Asp Phe Asp Leu Val Cys Val Asn Ala Trp Met Leu
             580                 585                 590

 gac ctc acc caa gcc atc ctg aac ctc ggc ttc ctg act gga gca ttc     1824
 Asp Leu Thr Gln Ala Ile Leu Asn Leu Gly Phe Leu Thr Gly Ala Phe
         595                 600                 605

 acc tta ggc tat gca gca gac agc agg agt aat agg aat ata gac tgg     1872
 Thr Leu Gly Tyr Ala Ala Asp Ser Arg Ser Asn Arg Asn Ile Asp Trp
     610                 615                 620

 aaa ttg ctg act cat ggc tgt atc tgg cct aat att gtt ctg gtt aat     1920
 Lys Leu Leu Thr His Gly Cys Ile Trp Pro Asn Ile Val Leu Val Asn
 625                 630                 635                 640

 cca tct ctg act cat ggc cat atc tgg cct aat att gtt ctg gtt aat     1968
 Pro Ser Leu Thr His Gly His Ile Trp Pro Asn Ile Val Leu Val Asn
                 645                 650                 655

 cga gcc cag ccc atg ctg tcc ttt gca tta gca gag cac aaa att ata     2016
 Arg Ala Gln Pro Met Leu Ser Phe Ala Leu Ala Glu His Lys Ile Ile
             660                 665                 670

 aga ggc aaa aac tgt gat aaa act gga atg aga aat aga tta atc cac     2064
 Arg Gly Lys Asn Cys Asp Lys Thr Gly Met Arg Asn Arg Leu Ile His
         675                 680                 685

 gat ttc act gga gac ttc aac atc cct ttg ttg gaa atg gtc aga ttc     2112
 Asp Phe Thr Gly Asp Phe Asn Ile Pro Leu Leu Glu Met Val Arg Phe
     690                 695                 700

 aac agg tat ggc agg atc gtc att tac ttg cta tcc tgc ctt ggt gtt     2160
 Asn Arg Tyr Gly Arg Ile Val Ile Tyr Leu Leu Ser Cys Leu Gly Val
 705                 710                 715                 720

 ggc gtc act ggg gtt gtg gtg gcc ttt gca cca aac ttc cct gtg ttt     2208
 Gly Val Thr Gly Val Val Val Ala Phe Ala Pro Asn Phe Pro Val Phe
                 725                 730                 735

 gtg atc ttc cgc ttc ctg caa ggt gta ttt gga aag ggg acg tgg atg     2256
 Val Ile Phe Arg Phe Leu Gln Gly Val Phe Gly Lys Gly Thr Trp Met
             740                 745                 750

 act tgc tac gtg att gtg aca gaa ata gta ggt tcg aaa caa agg agg     2304
 Thr Cys Tyr Val Ile Val Thr Glu Ile Val Gly Ser Lys Gln Arg Arg
         755                 760                 765

 att gtg gga atc gtg att caa atg ttc ttt acc ctt gga atc ata att     2352
 Ile Val Gly Ile Val Ile Gln Met Phe Phe Thr Leu Gly Ile Ile Ile
     770                 775                 780

 ctc cct gga att gcc tac ttc atc ccc aac tgg caa gga atc cag tta     2400
 Leu Pro Gly Ile Ala Tyr Phe Ile Pro Asn Trp Gln Gly Ile Gln Leu
 785                 790                 795                 800

 gcc atc acg ctg ccc agc ttt ctc ttc ctc ctt tat tac tgg gtg gtc     2448
 Ala Ile Thr Leu Pro Ser Phe Leu Phe Leu Leu Tyr Tyr Trp Val Val
                 805                 810                 815

 cct gag tct ccc cgt tgg ctg att act cgg aag aaa gga gat aaa gca     2496
 Pro Glu Ser Pro Arg Trp Leu Ile Thr Arg Lys Lys Gly Asp Lys Ala
             820                 825                 830

 tta cag atc ctg aga cgc att gct aag tgc aat ggg aaa tac ctc tca     2544
 Leu Gln Ile Leu Arg Arg Ile Ala Lys Cys Asn Gly Lys Tyr Leu Ser
         835                 840                 845

 tca aat tac tca gag aac agc aga tcc caa atc agt gct gtt cct tca     2592
 Ser Asn Tyr Ser Glu Asn Ser Arg Ser Gln Ile Ser Ala Val Pro Ser
     850                 855                 860

 ggg tgg gtc tca gaa gga gag cta cag cct gga gca gag ctg cag cag     2640
 Gly Trp Val Ser Glu Gly Glu Leu Gln Pro Gly Ala Glu Leu Gln Gln
 865                 870                 875                 880

 ctg acc tac agc tgc tgt atg gga cat ggc caa gaa aaa gct gtt tcc     2688
 Leu Thr Tyr Ser Cys Cys Met Gly His Gly Gln Glu Lys Ala Val Ser
                 885                 890                 895

 cca gta aac tac tgc tca atg tgt ctg cat gta cta cag aga ttt ggg     2736
 Pro Val Asn Tyr Cys Ser Met Cys Leu His Val Leu Gln Arg Phe Gly
             900                 905                 910

 ggt cag tgg gct gtc att caa cac cga aag ata ttg agg gga gga tgt     2784
 Gly Gln Trp Ala Val Ile Gln His Arg Lys Ile Leu Arg Gly Gly Cys
         915                 920                 925

 tct cct aca cct tta att gaa atg gaa att caa ttt aaa ggt gct tta     2832
 Ser Pro Thr Pro Leu Ile Glu Met Glu Ile Gln Phe Lys Gly Ala Leu
     930                 935                 940

 aag aat gag att gca gcc ttg gag cag gct agg cag act tgt ggg atg     2880
 Lys Asn Glu Ile Ala Ala Leu Glu Gln Ala Arg Gln Thr Cys Gly Met
 945                 950                 955                 960

 cct cat cag aca gca gca ttt tgc aca agg aac tat gag cct cat gtc     2928
 Pro His Gln Thr Ala Ala Phe Cys Thr Arg Asn Tyr Glu Pro His Val
                 965                 970                 975

 tac ctg gtt ctt cat ctg gtc ctg agt cct tgc cca ttc tac tgt ggc     2976
 Tyr Leu Val Leu His Leu Val Leu Ser Pro Cys Pro Phe Tyr Cys Gly
             980                 985                 990

 tct ggc cct gct tca ttc ctg cct gat tca tcc tca gaa ggc agg ttt     3024
 Ser Gly Pro Ala Ser Phe Leu Pro Asp Ser Ser Ser Glu Gly Arg Phe
         995                1000                1005

 ctg tcc tgt ccc tac aca tcc atg gcc tta aag caa gat gct gac gct     3072
 Leu Ser Cys Pro Tyr Thr Ser Met Ala Leu Lys Gln Asp Ala Asp Ala
    1010                1015                1020

 gtc ttg atg gct gga cct gcc ctt cct aga gac ggc tgc tgc caa ccc     3120
 Val Leu Met Ala Gly Pro Ala Leu Pro Arg Asp Gly Cys Cys Gln Pro
1025                1030                1035                1040

 att tcc cag aca acg tct gct ggg gaa ggg cct tct gat acc ctc tct     3168
 Ile Ser Gln Thr Thr Ser Ala Gly Glu Gly Pro Ser Asp Thr Leu Ser
                1045                1050                1055

 gga atc ctt cca ctc tat cag tgt gag gga aga ggc tca gct tct tca     3216
 Gly Ile Leu Pro Leu Tyr Gln Cys Glu Gly Arg Gly Ser Ala Ser Ser
            1060                1065                1070

 tgt atg ttg ctc ctt tgc cat ttg gtc cat tct tgt gtt ttc agc aaa     3264
 Cys Met Leu Leu Leu Cys His Leu Val His Ser Cys Val Phe Ser Lys
        1075                1080                1085

 acc agt ttc cac aat cca aat tac tgt gct tct cga ctg tgg ata aat     3312
 Thr Ser Phe His Asn Pro Asn Tyr Cys Ala Ser Arg Leu Trp Ile Asn
    1090                1095                1100

 gag aaa ata ctc ctc tct gtg aac gcg ctc ctt cgt gga gac agt aat     3360
 Glu Lys Ile Leu Leu Ser Val Asn Ala Leu Leu Arg Gly Asp Ser Asn
1105                1110                1115                1120

 gag tac aac ttc cag agc tct gcg cag cca gca acc ctg gca gga gtc     3408
 Glu Tyr Asn Phe Gln Ser Ser Ala Gln Pro Ala Thr Leu Ala Gly Val
                1125                1130                1135

 cct gtg tta ttc ata acc cag agc tgt gtt gcc atg gca gta ctg ctt     3456
 Pro Val Leu Phe Ile Thr Gln Ser Cys Val Ala Met Ala Val Leu Leu
            1140                1145                1150

 gct aga cct tgg acc cac cag gaa aat tat ctt tct tca tga             3498
 Ala Arg Pro Trp Thr His Gln Glu Asn Tyr Leu Ser Ser 
        1155                1160                1165





      <210> 900
      <211> 753
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (714)..(753)

      <400> 900
 atgttgtcta tcgctgcctt cacactacaa cagcagttga gtaagtgcga tggagaccat     60

 atggttcaca aagccgaaaa catttaccat ctgctccttt ataaaaaaaa agcttaccaa    120

 cctctgactt acgcaagtta ctcaaccatt gtaggtccca gcgacatctt tgtttcgcat    180

 gaacagaggg atggttgcgg actaaagaga gagattgcaa agcaccggtt aaaggatgcc    240

 atcaattcac agagaaacgt gtcggggacc cgggttagca gccctgcaaa acaggcaccc    300

 gctgatggcc ggtacgtcct gaatgttgcg gtccgatggc cggaagccgc cctccgccac    360

 ctcgaagatg aggcccatct tggtgcccga ggtgacccgc tcaaagaagc actcttcagc    420

 atgggcgtcg atgctaacga aatagcccga gaccgtggcc aggagagcgg ccaggagcac    480

 cagcagttca gcaagcgtca ccatggtggg gctgaggccg aagccaggac ccggactgcg    540

 gcctccacag ccgccgccgc cgccgccgcc gccccgctgc cttctcagcc accgccgcct    600

 aagctccgcc ccttccgcct gcgccaccag tgggggctga tgcgggcgca gtggattggc    660

 gggctcccgc agctgccacg ccctgccaca gggccacaga aggacctcac aca   ttt     716
                                                              Met
                                                                1

 cat gtc aat tga ggt cac tgg act gac ctg gga atg a                    753
 Cys Glu Val Leu Leu Trp Pro Cys Gly Arg Ala Trp Gln Leu Arg Glu 
               5                  10                  15





      <210> 901
      <211> 1716
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (1)..(1716)

      <400> 901
  atg gag acc ccg ccg tgg gac cca gcc cgc aac gac tcg ctg ccg ccc      48
  Met Glu Thr Pro Pro Trp Asp Pro Ala Arg Asn Asp Ser Leu Pro Pro
    1               5                  10                  15

 acg ctg acc ccg gcc gtg ccc ccc tac gtg aag ctt ggc ctc acc gtc       96
 Thr Leu Thr Pro Ala Val Pro Pro Tyr Val Lys Leu Gly Leu Thr Val
              20                  25                  30

 gtc tac acc gtg ttc tac gcg ctg ctc ttc gtg ttc atc tac gtg cag      144
 Val Tyr Thr Val Phe Tyr Ala Leu Leu Phe Val Phe Ile Tyr Val Gln
          35                  40                  45

 ctc tgg ctg gtg ctg cgt tac cgc cac aag cgg ctc agc tac cag agc      192
 Leu Trp Leu Val Leu Arg Tyr Arg His Lys Arg Leu Ser Tyr Gln Ser
      50                  55                  60

 gtc ttc ctc ttt ctc tgc ctc ttc tgg gcc tcc ctg cgg acc gtc ctc      240
 Val Phe Leu Phe Leu Cys Leu Phe Trp Ala Ser Leu Arg Thr Val Leu
  65                  70                  75                  80

 ttc tcc ttc tac ttc aaa gac ttc gtg gcg gcc aat tcg ctc agc ccc      288
 Phe Ser Phe Tyr Phe Lys Asp Phe Val Ala Ala Asn Ser Leu Ser Pro
                  85                  90                  95

 ttc gtc ttc tgg ctg ctc tac tgc ttc cct gtg tgc ctg cag ttt ttc      336
 Phe Val Phe Trp Leu Leu Tyr Cys Phe Pro Val Cys Leu Gln Phe Phe
             100                 105                 110

 acc ctc acg ctg atg aac ttg tac ttc acg cag gaa acc ccc tgc cat      384
 Thr Leu Thr Leu Met Asn Leu Tyr Phe Thr Gln Glu Thr Pro Cys His
         115                 120                 125

 tcc caa aag ggg caa gga gaa ggc agg gga ggg ctg gag gcc gcc gct      432
 Ser Gln Lys Gly Gln Gly Glu Gly Arg Gly Gly Leu Glu Ala Ala Ala
     130                 135                 140

 cac tcg ctg ccc ctg gct ccg cat cgt gcg gtg gat tcg ggg cgc ttc      480
 His Ser Leu Pro Leu Ala Pro His Arg Ala Val Asp Ser Gly Arg Phe
 145                 150                 155                 160

 tcc gtg cgc agc gcg aag cag cag cgc ctg cac acg cca gtt agt acg      528
 Ser Val Arg Ser Ala Lys Gln Gln Arg Leu His Thr Pro Val Ser Thr
                 165                 170                 175

 gat gga aga cct cag aat ggt ata tcc acc gac agc ttg cac tgc gct      576
 Asp Gly Arg Pro Gln Asn Gly Ile Ser Thr Asp Ser Leu His Cys Ala
             180                 185                 190

 cct gga aaa gcc aca gac act caa cac cag ccc gtg aaa gca gcc ggg      624
 Pro Gly Lys Ala Thr Asp Thr Gln His Gln Pro Val Lys Ala Ala Gly
         195                 200                 205

 aga gag gct gta ccc tgc aaa gcc aca ggg gtg gag ctg ccc aag acc      672
 Arg Glu Ala Val Pro Cys Lys Ala Thr Gly Val Glu Leu Pro Lys Thr
     210                 215                 220

 atg gga acc cac ctc ttg cat cac tgt gac ctg gat gtg att ttc aaa      720
 Met Gly Thr His Leu Leu His His Cys Asp Leu Asp Val Ile Phe Lys
 225                 230                 235                 240

 gcc aag tca aaa tat tct cca gaa tta ctc aaa tac cgg ttg ccc ctc      768
 Ala Lys Ser Lys Tyr Ser Pro Glu Leu Leu Lys Tyr Arg Leu Pro Leu
                 245                 250                 255

 tac ctg gcc tcc ctc ttc atc agc ctt gtt ttc ctg ttg gtg aat tta      816
 Tyr Leu Ala Ser Leu Phe Ile Ser Leu Val Phe Leu Leu Val Asn Leu
             260                 265                 270

 acc tgt gct gtg ctg gta aag acg gga aat tgg gag agg aag gtt atc      864
 Thr Cys Ala Val Leu Val Lys Thr Gly Asn Trp Glu Arg Lys Val Ile
         275                 280                 285

 gtc tct gtg cga gtg gcc att aat gac acg ctc ttc gtg ctg tgt gcc      912
 Val Ser Val Arg Val Ala Ile Asn Asp Thr Leu Phe Val Leu Cys Ala
     290                 295                 300

 gtc tct ctc tcc atc tgt ctc tac aaa atc tct aag atg tcc tta gcc      960
 Val Ser Leu Ser Ile Cys Leu Tyr Lys Ile Ser Lys Met Ser Leu Ala
 305                 310                 315                 320

 aac att tac ttg gag tcc aag ggc tcc tcc gtg tgt caa gtg act gcc     1008
 Asn Ile Tyr Leu Glu Ser Lys Gly Ser Ser Val Cys Gln Val Thr Ala
                 325                 330                 335

 atc ggt gtc acc gtg ata ctg ctt tac acc tct cgg gcc tgc tac aac     1056
 Ile Gly Val Thr Val Ile Leu Leu Tyr Thr Ser Arg Ala Cys Tyr Asn
             340                 345                 350

 ctg ttc atc ctg tca ttt tct cag aac aag agc gtc cat tcc ttt gat     1104
 Leu Phe Ile Leu Ser Phe Ser Gln Asn Lys Ser Val His Ser Phe Asp
         355                 360                 365

 tat gac tgg tac aat gta tca gac cag gtg gaa tgc ttt caa ctt ttc     1152
 Tyr Asp Trp Tyr Asn Val Ser Asp Gln Val Glu Cys Phe Gln Leu Phe
     370                 375                 380

 ctg att cag tat aat gtt ggc tgt ggg ttt gtc ata gat ggc ttt tat     1200
 Leu Ile Gln Tyr Asn Val Gly Cys Gly Phe Val Ile Asp Gly Phe Tyr
 385                 390                 395                 400

 tat ctt gat acc aac cct gga atg gtc ccc agc cat gga ttc agt ccc     1248
 Tyr Leu Asp Thr Asn Pro Gly Met Val Pro Ser His Gly Phe Ser Pro
                 405                 410                 415

 aga tct tat ttc ttt gac aac cct cga aga tat gac agt gat gat gac     1296
 Arg Ser Tyr Phe Phe Asp Asn Pro Arg Arg Tyr Asp Ser Asp Asp Asp
             420                 425                 430

 ctt gcc tgg aac att gcc cct cag gga ctt cag gga ggc ctg ctg tgc     1344
 Leu Ala Trp Asn Ile Ala Pro Gln Gly Leu Gln Gly Gly Leu Leu Cys
         435                 440                 445

 tca gcc ata ctc cac tac ccg atg act atc atg ttt ccc ctt tca gcc     1392
 Ser Ala Ile Leu His Tyr Pro Met Thr Ile Met Phe Pro Leu Ser Ala
     450                 455                 460

 tgt ggc tct gag acg att tgt ata tcc aac tgc cta cct gaa atc tcc     1440
 Cys Gly Ser Glu Thr Ile Cys Ile Ser Asn Cys Leu Pro Glu Ile Ser
 465                 470                 475                 480

 aag tgg atg tct cac agg cag ctc aaa ctt aac aaa tcc aaa ttt gac     1488
 Lys Trp Met Ser His Arg Gln Leu Lys Leu Asn Lys Ser Lys Phe Asp
                 485                 490                 495

 tat aac ttt gtc tca gac ttg ctc ctc ctc cag ctg tcc aca gct tct     1536
 Tyr Asn Phe Val Ser Asp Leu Leu Leu Leu Gln Leu Ser Thr Ala Ser
             500                 505                 510

 ctg caa gga aag aag aaa cca aag cac aca tct aac atc cca ata tct     1584
 Leu Gln Gly Lys Lys Lys Pro Lys His Thr Ser Asn Ile Pro Ile Ser
         515                 520                 525

 cta gtc ata tcc caa ggg aat ggc ttc tat acc acc tct ctc aag gca     1632
 Leu Val Ile Ser Gln Gly Asn Gly Phe Tyr Thr Thr Ser Leu Lys Ala
     530                 535                 540

 ata gta caa ctt gac tct aat ttc ttg gag gcc act aag aac aga gac     1680
 Ile Val Gln Leu Asp Ser Asn Phe Leu Glu Ala Thr Lys Asn Arg Asp
 545                 550                 555                 560

 agc agg ctg gac aag cac aaa gtt ttg cga aac tag                     1716
 Ser Arg Leu Asp Lys His Lys Val Leu Arg Asn 
                 565                 570





      <210> 902
      <211> 2706
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (1)..(2706)

      <400> 902
  atg atg atg gtg atg gtg atg atg atg ctg atg atg atg gtg att atg      48
  Met Met Met Val Met Val Met Met Met Leu Met Met Met Val Ile Met
    1               5                  10                  15

 atg gtg atg gtg gtg atg ctg atg atg ctg ctg ctg atg atg atg ctg       96
 Met Val Met Val Val Met Leu Met Met Leu Leu Leu Met Met Met Leu
              20                  25                  30

 atg atg gtg atg atg atg gtg atg atg gtg ata gtg atg atg atg gtg      144
 Met Met Val Met Met Met Val Met Met Val Ile Val Met Met Met Val
          35                  40                  45

 ata atg gtg gta atg atg gtg atg atg acg gtg atg ata atg gtg atg      192
 Ile Met Val Val Met Met Val Met Met Thr Val Met Ile Met Val Met
      50                  55                  60

 gtg gtg atg ctg atg ctg gtg atg gtg gtg atg atg atg gtg atg gtg      240
 Val Val Met Leu Met Leu Val Met Val Val Met Met Met Val Met Val
  65                  70                  75                  80

 gtg atg ctg atg ctg gtg atg gtg gtg atg atg atg atg atg gaa ctc      288
 Val Met Leu Met Leu Val Met Val Val Met Met Met Met Met Glu Leu
                  85                  90                  95

 gtg ctt ccc ttt ctt gct cta agt cga gca gca ggc atc agt tat gac      336
 Val Leu Pro Phe Leu Ala Leu Ser Arg Ala Ala Gly Ile Ser Tyr Asp
             100                 105                 110

 tgc ccc att gca gcg gcc tcg gct gca cct gct cga gga atc aca gag      384
 Cys Pro Ile Ala Ala Ala Ser Ala Ala Pro Ala Arg Gly Ile Thr Glu
         115                 120                 125

 gat tct aag ctg act gtc gtg gtc ctt tct ccc agg atg gaa gaa gcg      432
 Asp Ser Lys Leu Thr Val Val Val Leu Ser Pro Arg Met Glu Glu Ala
     130                 135                 140

 agc ctg tgc ctt gga gtg tct tcg gcg gag ccg gaa gct gag ccc cac      480
 Ser Leu Cys Leu Gly Val Ser Ser Ala Glu Pro Glu Ala Glu Pro His
 145                 150                 155                 160

 ctg agt ggc ccc gtc ctc aac ggc cag tat gcc atg agt cag aag ctg      528
 Leu Ser Gly Pro Val Leu Asn Gly Gln Tyr Ala Met Ser Gln Lys Leu
                 165                 170                 175

 cac cag atc acc tcc cag ctc agc cat gcc ttc ccc gag ctc cat ccc      576
 His Gln Ile Thr Ser Gln Leu Ser His Ala Phe Pro Glu Leu His Pro
             180                 185                 190

 cgg ccc aac ccc gag gag aag ccc ccc gca tcc ctg gag gag aag gcc      624
 Arg Pro Asn Pro Glu Glu Lys Pro Pro Ala Ser Leu Glu Glu Lys Ala
         195                 200                 205

 cac gtg ccc atg agc ggc cag ccc atg ggc agt cag atg gcg ctc ctg      672
 His Val Pro Met Ser Gly Gln Pro Met Gly Ser Gln Met Ala Leu Leu
     210                 215                 220

 gcc aac cag ctg ggc cgg gag gtg gac acc agc ctc aac ggg agg gtg      720
 Ala Asn Gln Leu Gly Arg Glu Val Asp Thr Ser Leu Asn Gly Arg Val
 225                 230                 235                 240

 gac ttg cag cag ttc ctc aac ggg cag aac ctg ggc atc atg tcc cag      768
 Asp Leu Gln Gln Phe Leu Asn Gly Gln Asn Leu Gly Ile Met Ser Gln
                 245                 250                 255

 atg agc gac atc gag gac gac gcc cgc aag aac cgc aag tac ccg tgc      816
 Met Ser Asp Ile Glu Asp Asp Ala Arg Lys Asn Arg Lys Tyr Pro Cys
             260                 265                 270

 cca ctc tgc ggc aag cgc ttc cgc ttc aac agc atc ctc tcc ctg cac      864
 Pro Leu Cys Gly Lys Arg Phe Arg Phe Asn Ser Ile Leu Ser Leu His
         275                 280                 285

 atg cgc acg cac acg ggc gag aag ccc ttc aag tgc ccg tac tgc gac      912
 Met Arg Thr His Thr Gly Glu Lys Pro Phe Lys Cys Pro Tyr Cys Asp
     290                 295                 300

 cac agg gcg gcg cag aag ggg aac ctc aag att cac ctg cgg acc cac      960
 His Arg Ala Ala Gln Lys Gly Asn Leu Lys Ile His Leu Arg Thr His
 305                 310                 315                 320

 aag ctg ggc aac ctg ggc aag ggg cgt ggg cgt gtg cgc gag gag aac     1008
 Lys Leu Gly Asn Leu Gly Lys Gly Arg Gly Arg Val Arg Glu Glu Asn
                 325                 330                 335

 cgc ctg ctg cac gag ctg gag gag cgc gcc atc ctg cgg gac aag cag     1056
 Arg Leu Leu His Glu Leu Glu Glu Arg Ala Ile Leu Arg Asp Lys Gln
             340                 345                 350

 ctg aaa ggc agc ctg ctg cag ccc cgg ccg gac ctg aag ccc ccg ccg     1104
 Leu Lys Gly Ser Leu Leu Gln Pro Arg Pro Asp Leu Lys Pro Pro Pro
         355                 360                 365

 cac gcc cag cag gcc ccg ctg gcc gcc tgc acc ctg gcc ctg cag gct     1152
 His Ala Gln Gln Ala Pro Leu Ala Ala Cys Thr Leu Ala Leu Gln Ala
     370                 375                 380

 aac cac agc gtt ccc gac gtg gcc cac ccg gtg ccc tcg ccc aag cct     1200
 Asn His Ser Val Pro Asp Val Ala His Pro Val Pro Ser Pro Lys Pro
 385                 390                 395                 400

 gcc agc gtg cag gag gac gcg gtg gcc ccg gcg gcg ggc ttc cgc tgt     1248
 Ala Ser Val Gln Glu Asp Ala Val Ala Pro Ala Ala Gly Phe Arg Cys
                 405                 410                 415

 acc ttc tgc aag ggc aag ttc aag aag cgc gag gag ctg gac cgc cac     1296
 Thr Phe Cys Lys Gly Lys Phe Lys Lys Arg Glu Glu Leu Asp Arg His
             420                 425                 430

 atc cgc atc ttg cac aag ccc tac aag tgc acg ttg tgc gac ttc gcg     1344
 Ile Arg Ile Leu His Lys Pro Tyr Lys Cys Thr Leu Cys Asp Phe Ala
         435                 440                 445

 gct tcg cag gag gag gag ctc atc agc cac gtg gag aag gca cac atc     1392
 Ala Ser Gln Glu Glu Glu Leu Ile Ser His Val Glu Lys Ala His Ile
     450                 455                 460

 acg gcc gag tcg gcc cag ggc cag ggc ccc aac ggc ggt ggc gag cag     1440
 Thr Ala Glu Ser Ala Gln Gly Gln Gly Pro Asn Gly Gly Gly Glu Gln
 465                 470                 475                 480

 tcg gcc aac gag ttc cgc tgc gag gtg tgc ggt cag gtg ttc agc cag     1488
 Ser Ala Asn Glu Phe Arg Cys Glu Val Cys Gly Gln Val Phe Ser Gln
                 485                 490                 495

 gcg tgg ttc ctc aag ggt cac atg cgc aag cac aaa gac tcc ttt gag     1536
 Ala Trp Phe Leu Lys Gly His Met Arg Lys His Lys Asp Ser Phe Glu
             500                 505                 510

 cac tgc tgc cag atc tgc ggc cgg cgc ttc aag gag ccc tgg ttc ctc     1584
 His Cys Cys Gln Ile Cys Gly Arg Arg Phe Lys Glu Pro Trp Phe Leu
         515                 520                 525

 aag aac cac atg aag gtc cac ctc aac aag ctg tcg gtg aag aac aag     1632
 Lys Asn His Met Lys Val His Leu Asn Lys Leu Ser Val Lys Asn Lys
     530                 535                 540

 tcc ccc agc gac ccc gag gtg cct gtg ccc atg ggc ggc atg tcc cag     1680
 Ser Pro Ser Asp Pro Glu Val Pro Val Pro Met Gly Gly Met Ser Gln
 545                 550                 555                 560

 gag gcc cac gcc aac ctg tac tcc agg tac ctc tcc tgc ctg cag agt     1728
 Glu Ala His Ala Asn Leu Tyr Ser Arg Tyr Leu Ser Cys Leu Gln Ser
                 565                 570                 575

 ggc ttc atg acc ccg gac aaa gcc ggc ctg agc gag ccc agc cag ctc     1776
 Gly Phe Met Thr Pro Asp Lys Ala Gly Leu Ser Glu Pro Ser Gln Leu
             580                 585                 590

 tat ggc aag ggc gag ctg ccc atg aag gag aag gaa gcg ctg ggg aag     1824
 Tyr Gly Lys Gly Glu Leu Pro Met Lys Glu Lys Glu Ala Leu Gly Lys
         595                 600                 605

 ctg ctg tct ccc atc tcc agc atg gcc cac ggc gtc ccg gag ggg gac     1872
 Leu Leu Ser Pro Ile Ser Ser Met Ala His Gly Val Pro Glu Gly Asp
     610                 615                 620

 aag cac tcc ctc ctg gga tgc ctc aat ctc gtg ccg ccg ctg aaa tcc     1920
 Lys His Ser Leu Leu Gly Cys Leu Asn Leu Val Pro Pro Leu Lys Ser
 625                 630                 635                 640

 agc tgc atc gag cgg ctg cag gcg gct gcc aag gct gcg gag atg gac     1968
 Ser Cys Ile Glu Arg Leu Gln Ala Ala Ala Lys Ala Ala Glu Met Asp
                 645                 650                 655

 ccc gtg aac agc tac cag gct tgg cag ctc atg gcc agg ggc atg gcc     2016
 Pro Val Asn Ser Tyr Gln Ala Trp Gln Leu Met Ala Arg Gly Met Ala
             660                 665                 670

 atg gaa cat ggc ttc ttg tct aaa gag cat ccg ctg cag cgc aac cac     2064
 Met Glu His Gly Phe Leu Ser Lys Glu His Pro Leu Gln Arg Asn His
         675                 680                 685

 gaa gac act ttg gca aac gcc ggg gtt ctg ttt gat aag gag aag cgg     2112
 Glu Asp Thr Leu Ala Asn Ala Gly Val Leu Phe Asp Lys Glu Lys Arg
     690                 695                 700

 gag tac gtg tta gtg gga gca gat ggc tcc aag cag aaa atg cct gct     2160
 Glu Tyr Val Leu Val Gly Ala Asp Gly Ser Lys Gln Lys Met Pro Ala
 705                 710                 715                 720

 gat ttg gtt cac agc act aaa gtg ggc agc cag aga gac ctg cca agt     2208
 Asp Leu Val His Ser Thr Lys Val Gly Ser Gln Arg Asp Leu Pro Ser
                 725                 730                 735

 aag ctc gac cct tta gaa agc agt cgg gat ttt ttg tca cac ggg ctg     2256
 Lys Leu Asp Pro Leu Glu Ser Ser Arg Asp Phe Leu Ser His Gly Leu
             740                 745                 750

 aac cag act ctc gag tat aac ctg cag ggt cct ggg aac atg aag gag     2304
 Asn Gln Thr Leu Glu Tyr Asn Leu Gln Gly Pro Gly Asn Met Lys Glu
         755                 760                 765

 aag ccc acc gag tgc ccc gac tgc ggc cgg gtg ttc cgc act tac cac     2352
 Lys Pro Thr Glu Cys Pro Asp Cys Gly Arg Val Phe Arg Thr Tyr His
     770                 775                 780

 cag gtg gtc gtg cac tcc cgt gtc cac aag cgg gac cgc aag ggc gag     2400
 Gln Val Val Val His Ser Arg Val His Lys Arg Asp Arg Lys Gly Glu
 785                 790                 795                 800

 gag gat ggg ctg cac gtg ggc ctg gat gag cgg cgt ggc tcg ggc agt     2448
 Glu Asp Gly Leu His Val Gly Leu Asp Glu Arg Arg Gly Ser Gly Ser
                 805                 810                 815

 gac cag gag tcc cag tcg gtg agc cgc tcc acc acg ccg ggc tcc tct     2496
 Asp Gln Glu Ser Gln Ser Val Ser Arg Ser Thr Thr Pro Gly Ser Ser
             820                 825                 830

 aac gtc acc gag gag agc ggg gtc gga ggc ggc ctc tcc cag acc ggg     2544
 Asn Val Thr Glu Glu Ser Gly Val Gly Gly Gly Leu Ser Gln Thr Gly
         835                 840                 845

 agt gcc cag gag gac agc ccg cac ccc tcc tcg cca tcc tcc tca gcg     2592
 Ser Ala Gln Glu Asp Ser Pro His Pro Ser Ser Pro Ser Ser Ser Ala
     850                 855                 860

 tat tcc cat aat tct ctc atg cag gca ccg cag tct ccc tcc cca agc     2640
 Tyr Ser His Asn Ser Leu Met Gln Ala Pro Gln Ser Pro Ser Pro Ser
 865                 870                 875                 880

 caa acc tat ctt ctg gcc cct tcc aaa att aca acg tgg ctc acc tgc     2688
 Gln Thr Tyr Leu Leu Ala Pro Ser Lys Ile Thr Thr Trp Leu Thr Cys
                 885                 890                 895

 cag atc cgt gtg acc taa                                             2706
 Gln Ile Arg Val Thr 
             900





      <210> 903
      <211> 1737
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (1)..(1737)

      <400> 903
  atg ccg agc tac gcg cag cta gtg cag cgc ggc tgg ggc agc gcg ctg      48
  Met Pro Ser Tyr Ala Gln Leu Val Gln Arg Gly Trp Gly Ser Ala Leu
    1               5                  10                  15

 gcg gcg gcg cgg ggc tgc acg gac tgc ggc tgg ggg ctg gcg cgt cgc       96
 Ala Ala Ala Arg Gly Cys Thr Asp Cys Gly Trp Gly Leu Ala Arg Arg
              20                  25                  30

 ggc ctg gct gag cac gcg cac ctg gcg ccg ccc gag ctg ctg ctg ctg      144
 Gly Leu Ala Glu His Ala His Leu Ala Pro Pro Glu Leu Leu Leu Leu
          35                  40                  45

 gcg ctc ggc gcg ctg ggc tgg acc gcc ctg cgc tcc gcg gcc act gcg      192
 Ala Leu Gly Ala Leu Gly Trp Thr Ala Leu Arg Ser Ala Ala Thr Ala
      50                  55                  60

 cgc ctc ttt cgg gtc agt gtg gcc ggg ggc cgg gac gag ggg acc ccg      240
 Arg Leu Phe Arg Val Ser Val Ala Gly Gly Arg Asp Glu Gly Thr Pro
  65                  70                  75                  80

 gac tgg ggg aag ccg gga ccg ggg acc tgg ggc cgc cgg cgc gtt cct      288
 Asp Trp Gly Lys Pro Gly Pro Gly Thr Trp Gly Arg Arg Arg Val Pro
                  85                  90                  95

 ttc ttc cag cgc tgg ctg ctg cgg atg aag ggg tcg ccg gaa cgt ggg      336
 Phe Phe Gln Arg Trp Leu Leu Arg Met Lys Gly Ser Pro Glu Arg Gly
             100                 105                 110

 gcc gag cca gac act gag aag ccc agg acc ggg aac ggg agg gct cgg      384
 Ala Glu Pro Asp Thr Glu Lys Pro Arg Thr Gly Asn Gly Arg Ala Arg
         115                 120                 125

 cgc acc gcg gcc tgc gcc atg cgc ctc cct gcc atg cgg gct gcg ccc      432
 Arg Thr Ala Ala Cys Ala Met Arg Leu Pro Ala Met Arg Ala Ala Pro
     130                 135                 140

 cgg ccc gga gcg agg tcc gct gcc cgt ttt ctg ctg ggt ccg tgc ggc      480
 Arg Pro Gly Ala Arg Ser Ala Ala Arg Phe Leu Leu Gly Pro Cys Gly
 145                 150                 155                 160

 ggc ggg gcc ggc ttg ccc gct gta atc ggg aag agg cag gag ctg ccc      528
 Gly Gly Ala Gly Leu Pro Ala Val Ile Gly Lys Arg Gln Glu Leu Pro
                 165                 170                 175

 ggt cgc tgc ctt gtg cct atc tgg ggt cag cgc cac cct ccg acc agg      576
 Gly Arg Cys Leu Val Pro Ile Trp Gly Gln Arg His Pro Pro Thr Arg
             180                 185                 190

 gat ggc aag ggc ctg ggt gct ctg gcc acg cca gtg gtc gct ccc ttg      624
 Asp Gly Lys Gly Leu Gly Ala Leu Ala Thr Pro Val Val Ala Pro Leu
         195                 200                 205

 gag ccc ctg gcg aag cgg tgc tgc ctc cag ccc aga gat gcc gcc aag      672
 Glu Pro Leu Ala Lys Arg Cys Cys Leu Gln Pro Arg Asp Ala Ala Lys
     210                 215                 220

 atg ccc gag agc gct tgg aag ttt ctc ttc tac ctg ggc agc tgg agc      720
 Met Pro Glu Ser Ala Trp Lys Phe Leu Phe Tyr Leu Gly Ser Trp Ser
 225                 230                 235                 240

 tac agt gcc tac ctg ctg ttt ggc acc gac tac ccc ttc ttc cat gac      768
 Tyr Ser Ala Tyr Leu Leu Phe Gly Thr Asp Tyr Pro Phe Phe His Asp
                 245                 250                 255

 cca cca tct gtc ttc tac gac tgg acg ccg ggc atg gca gtg cca cgg      816
 Pro Pro Ser Val Phe Tyr Asp Trp Thr Pro Gly Met Ala Val Pro Arg
             260                 265                 270

 gac att gca gcc gcc tac ctg ctc cag gga agc ttc tat ggc cac tcc      864
 Asp Ile Ala Ala Ala Tyr Leu Leu Gln Gly Ser Phe Tyr Gly His Ser
         275                 280                 285

 atc tac gct acg cta tac atg gac acc tgg cgc aag gac tcg gtg gtc      912
 Ile Tyr Ala Thr Leu Tyr Met Asp Thr Trp Arg Lys Asp Ser Val Val
     290                 295                 300

 atg ctg ctc cac cac gtg gtc act ctc atc ctc atc gtc tcc tcc tac      960
 Met Leu Leu His His Val Val Thr Leu Ile Leu Ile Val Ser Ser Tyr
 305                 310                 315                 320

 gcc ttc cgg tac cac aat gtg ggc atc ctt gtg ctc ttc ctg cac gat     1008
 Ala Phe Arg Tyr His Asn Val Gly Ile Leu Val Leu Phe Leu His Asp
                 325                 330                 335

 atc agt gac gtg cag ctt gag ttc acc aag ctc aac att tac ttc aag     1056
 Ile Ser Asp Val Gln Leu Glu Phe Thr Lys Leu Asn Ile Tyr Phe Lys
             340                 345                 350

 tcc cgc ggc ggc tcc tac cat cgg ctg cat gcc ttg gca gca gac ttg     1104
 Ser Arg Gly Gly Ser Tyr His Arg Leu His Ala Leu Ala Ala Asp Leu
         355                 360                 365

 ggc tgc ctc agc ttc ggc ttc agc tgg ttc tgg ttc cgc ctc tac tgg     1152
 Gly Cys Leu Ser Phe Gly Phe Ser Trp Phe Trp Phe Arg Leu Tyr Trp
     370                 375                 380

 ttc ccg ctc aag gtc ctg tat gcc acc agt cac tgc agt ctg cgc acg     1200
 Phe Pro Leu Lys Val Leu Tyr Ala Thr Ser His Cys Ser Leu Arg Thr
 385                 390                 395                 400

 gtg cct gac atc ccc ttc tac ttc ttc ttc aat gcg ctc ctg ctg ctg     1248
 Val Pro Asp Ile Pro Phe Tyr Phe Phe Phe Asn Ala Leu Leu Leu Leu
                 405                 410                 415

 ctc acc ctt atg aac ctc tac tgg ttc ctg tac atc gtg gcg ttt gca     1296
 Leu Thr Leu Met Asn Leu Tyr Trp Phe Leu Tyr Ile Val Ala Phe Ala
             420                 425                 430

 gcc aag gtg ttg aca ggc cag gtg cac gag ctg aag gac ctg cgg gag     1344
 Ala Lys Val Leu Thr Gly Gln Val His Glu Leu Lys Asp Leu Arg Glu
         435                 440                 445

 tat gac aca gcc gag gcc cag agc ctg aag ccc agc aaa gcc gag cac     1392
 Tyr Asp Thr Ala Glu Ala Gln Ser Leu Lys Pro Ser Lys Ala Glu His
     450                 455                 460

 cac cag cag aat tcg att ctc caa gga cag ccg gag tta gtg cag ttg     1440
 His Gln Gln Asn Ser Ile Leu Gln Gly Gln Pro Glu Leu Val Gln Leu
 465                 470                 475                 480

 ggt ata aaa cag gat ggg acg aag gca gtc agg ctg aga gac gtc ttc     1488
 Gly Ile Lys Gln Asp Gly Thr Lys Ala Val Arg Leu Arg Asp Val Phe
                 485                 490                 495

 caa aag agc ccg tca gga tgc cca gaa act gtc aag atc atg gga atc     1536
 Gln Lys Ser Pro Ser Gly Cys Pro Glu Thr Val Lys Ile Met Gly Ile
             500                 505                 510

 agg gaa aga ccg agg aac aat cca ggg tca gag gag acc aag gag aca     1584
 Arg Glu Arg Pro Arg Asn Asn Pro Gly Ser Glu Glu Thr Lys Glu Thr
         515                 520                 525

 gat gcc acc tgc agc atg ggc tcc tgg acc agg aaa ggg acc ttc acc     1632
 Asp Ala Thr Cys Ser Met Gly Ser Trp Thr Arg Lys Gly Thr Phe Thr
     530                 535                 540

 aag aag ctg gtg aat tca aat cat gtg gag agt tta gtt aat agc aaa     1680
 Lys Lys Leu Val Asn Ser Asn His Val Glu Ser Leu Val Asn Ser Lys
 545                 550                 555                 560

 gca cca atg tcg gtt tct tta gct gca acc cat gtg cca tgg aaa tgt     1728
 Ala Pro Met Ser Val Ser Leu Ala Ala Thr His Val Pro Trp Lys Cys
                 565                 570                 575

 aag ctg taa                                                         1737
 Lys Leu 






      <210> 904
      <211> 1563
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (1)..(1563)

      <400> 904
  atg ggc cct gct ggc tgt gcc ttc acg ctg ctc ctt ctg ctg ggg atc      48
  Met Gly Pro Ala Gly Cys Ala Phe Thr Leu Leu Leu Leu Leu Gly Ile
    1               5                  10                  15

 tca gtg tgt ggg caa cct gta tac tcc agc cgc gtt gta ggt ggc cag       96
 Ser Val Cys Gly Gln Pro Val Tyr Ser Ser Arg Val Val Gly Gly Gln
              20                  25                  30

 gat gct gct gca ggg cgc tgg cct tgg cag gtc agc cta cac ttt gac      144
 Asp Ala Ala Ala Gly Arg Trp Pro Trp Gln Val Ser Leu His Phe Asp
          35                  40                  45

 cac aac ttt atc tgt gga ggt tcc ctc gtc agt gag agg ttg ata ctg      192
 His Asn Phe Ile Cys Gly Gly Ser Leu Val Ser Glu Arg Leu Ile Leu
      50                  55                  60

 aca gca gca cac tgc ata caa cca agc cat agg aga atc tgc tcc acc      240
 Thr Ala Ala His Cys Ile Gln Pro Ser His Arg Arg Ile Cys Ser Thr
  65                  70                  75                  80

 aaa ata aag ggg gaa aaa cag gaa aac aca gga tcc aga caa aag ggg      288
 Lys Ile Lys Gly Glu Lys Gln Glu Asn Thr Gly Ser Arg Gln Lys Gly
                  85                  90                  95

 aat aaa aca cag aag aga atc cct aag aaa gtc ata aag gat aaa gaa      336
 Asn Lys Thr Gln Lys Arg Ile Pro Lys Lys Val Ile Lys Asp Lys Glu
             100                 105                 110

 agt gcc aag atg atg gct gtg cag cag ccc aga tta gaa caa gag agc      384
 Ser Ala Lys Met Met Ala Val Gln Gln Pro Arg Leu Glu Gln Glu Ser
         115                 120                 125

 aga ggg ctc caa aaa aaa gat agt att gat aga atg cct gac aag ttt      432
 Arg Gly Leu Gln Lys Lys Asp Ser Ile Asp Arg Met Pro Asp Lys Phe
     130                 135                 140

 gaa caa aat gag agg aga ttt aca ctt ctg gtg gag agc ctg ggg aat      480
 Glu Gln Asn Glu Arg Arg Phe Thr Leu Leu Val Glu Ser Leu Gly Asn
 145                 150                 155                 160

 gag act ggt gat ggg tat aaa gat aaa aac aaa aaa cca aag acc tgg      528
 Glu Thr Gly Asp Gly Tyr Lys Asp Lys Asn Lys Lys Pro Lys Thr Trp
                 165                 170                 175

 act act ttt tca tat act gtg tgg cta gga tcg att aca gta ggt gac      576
 Thr Thr Phe Ser Tyr Thr Val Trp Leu Gly Ser Ile Thr Val Gly Asp
             180                 185                 190

 tca agg aaa cgt gtg aag tac tac gtg tcc aaa atc gtc atc cat ccc      624
 Ser Arg Lys Arg Val Lys Tyr Tyr Val Ser Lys Ile Val Ile His Pro
         195                 200                 205

 aag tac caa gat aca acg gca gac gtc gcc ttg ttg aaa ctg tcc tct      672
 Lys Tyr Gln Asp Thr Thr Ala Asp Val Ala Leu Leu Lys Leu Ser Ser
     210                 215                 220

 caa gtc acc ttc act tct gcc atc ctg cct att tgc ttg ccc agt gtc      720
 Gln Val Thr Phe Thr Ser Ala Ile Leu Pro Ile Cys Leu Pro Ser Val
 225                 230                 235                 240

 aca aag cag ttg gca att cca ccc ttt tgt tgg gtg acc gga tgg gga      768
 Thr Lys Gln Leu Ala Ile Pro Pro Phe Cys Trp Val Thr Gly Trp Gly
                 245                 250                 255

 aaa gtt aag gaa agt tca gat aga gat tac cat tct gcc ctt cag gaa      816
 Lys Val Lys Glu Ser Ser Asp Arg Asp Tyr His Ser Ala Leu Gln Glu
             260                 265                 270

 gca gaa gta ccc att att gac cgc cag gct tgt gaa cag ctc tac aat      864
 Ala Glu Val Pro Ile Ile Asp Arg Gln Ala Cys Glu Gln Leu Tyr Asn
         275                 280                 285

 ccc atc ggt atc ttc ttg cca gca ctg gag cca gtc atc aag gaa gac      912
 Pro Ile Gly Ile Phe Leu Pro Ala Leu Glu Pro Val Ile Lys Glu Asp
     290                 295                 300

 aag att tgt gct ggt gat act caa aac atg aag gat agt tgc aag ggt      960
 Lys Ile Cys Ala Gly Asp Thr Gln Asn Met Lys Asp Ser Cys Lys Gly
 305                 310                 315                 320

 gat tct gga ggg cct ctg tcg tgt cac att gat ggt gta tgg atc cag     1008
 Asp Ser Gly Gly Pro Leu Ser Cys His Ile Asp Gly Val Trp Ile Gln
                 325                 330                 335

 aca gga gta cac ttc aaa ggc atc ctc ctg ctg ctc aca gaa atc tgt     1056
 Thr Gly Val His Phe Lys Gly Ile Leu Leu Leu Leu Thr Glu Ile Cys
             340                 345                 350

 gaa tat gtt act aca cgt agt aaa ggg gat ttt gca cat atg att aag     1104
 Glu Tyr Val Thr Thr Arg Ser Lys Gly Asp Phe Ala His Met Ile Lys
         355                 360                 365

 tat cct gag atg ggg aca tca tct gta tta tct ggt ggg acc aat gta     1152
 Tyr Pro Glu Met Gly Thr Ser Ser Val Leu Ser Gly Gly Thr Asn Val
     370                 375                 380

 atc aat cac atg gct tct tat aag agt aag ata gga gga tca ggg cca     1200
 Ile Asn His Met Ala Ser Tyr Lys Ser Lys Ile Gly Gly Ser Gly Pro
 385                 390                 395                 400

 gtg tct ccc ttc tta cct gaa caa cat gag cct tct ttg gcc aaa tat     1248
 Val Ser Pro Phe Leu Pro Glu Gln His Glu Pro Ser Leu Ala Lys Tyr
                 405                 410                 415

 cca aat cta cat tta agc ttc aaa agc caa att aat cag gac cca agg     1296
 Pro Asn Leu His Leu Ser Phe Lys Ser Gln Ile Asn Gln Asp Pro Arg
             420                 425                 430

 tgg cgc agc cct cgt gag ccc aaa aag cca ctc gcg tct ggg cgc caa     1344
 Trp Arg Ser Pro Arg Glu Pro Lys Lys Pro Leu Ala Ser Gly Arg Gln
         435                 440                 445

 ccc tta ggc tct gcc ttc cca gag ttc ctg gtg cta gac ccg tca ggc     1392
 Pro Leu Gly Ser Ala Phe Pro Glu Phe Leu Val Leu Asp Pro Ser Gly
     450                 455                 460

 agg aca agc tta cag ttc ctg aag gtg agg cca aca gct gct gag gag     1440
 Arg Thr Ser Leu Gln Phe Leu Lys Val Arg Pro Thr Ala Ala Glu Glu
 465                 470                 475                 480

 caa gga ctc gtt cca gct gct tct aaa caa ggg ggc cag gcc tct gcc     1488
 Gln Gly Leu Val Pro Ala Ala Ser Lys Gln Gly Gly Gln Ala Ser Ala
                 485                 490                 495

 aga gcc ttc tcc ttc ctg ccc tgt gtc aag cta tcc aag ctt cct cct     1536
 Arg Ala Phe Ser Phe Leu Pro Cys Val Lys Leu Ser Lys Leu Pro Pro
             500                 505                 510

 caa cct tta ccc tgc cct atg ccc tga                                 1563
 Gln Pro Leu Pro Cys Pro Met Pro 
         515                 520





      <210> 905
      <211> 642
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (1)..(642)

      <400> 905
  atg acg ctg gcg ctc tcc tct acg gcg att gcc atg cag gcg atg aat      48
  Met Thr Leu Ala Leu Ser Ser Thr Ala Ile Ala Met Gln Ala Met Asn
    1               5                  10                  15

 gaa cgc aat ctg atg gtg acg caa atg ggt cgc agt gcc ttt gcg gtg       96
 Glu Arg Asn Leu Met Val Thr Gln Met Gly Arg Ser Ala Phe Ala Val
              20                  25                  30

 ctg ctg ttc cag gat atc gcg gcg atc ccg ctg gtg gcg atg att ccg      144
 Leu Leu Phe Gln Asp Ile Ala Ala Ile Pro Leu Val Ala Met Ile Pro
          35                  40                  45

 cta ctg gca acg agc agt gcc tcg acg acg atg ggc gca ttt gct ctc      192
 Leu Leu Ala Thr Ser Ser Ala Ser Thr Thr Met Gly Ala Phe Ala Leu
      50                  55                  60

 tcg gcg tta aaa gtg gcg ggt gcg ctg gtg ctg gtg gta ttg ctg ggg      240
 Ser Ala Leu Lys Val Ala Gly Ala Leu Val Leu Val Val Leu Leu Gly
  65                  70                  75                  80

 cgc tat gtc acg cgt ccg gcg ctg cgt ttt gta gcc cgc tct ggc ttg      288
 Arg Tyr Val Thr Arg Pro Ala Leu Arg Phe Val Ala Arg Ser Gly Leu
                  85                  90                  95

 cgg gaa gtg ttt agt gcc gtg gcg tta ttc ctc gtg ttt ggc ttt ggt      336
 Arg Glu Val Phe Ser Ala Val Ala Leu Phe Leu Val Phe Gly Phe Gly
             100                 105                 110

 ttg ctg ctg gaa gag gtc ggc ttg tcg atg gcg atg ggc gcg ttt ctg      384
 Leu Leu Leu Glu Glu Val Gly Leu Ser Met Ala Met Gly Ala Phe Leu
         115                 120                 125

 gcg ggc gta ctg ctg gca agc tcg gaa tac cgt cat gcg ctg gag agc      432
 Ala Gly Val Leu Leu Ala Ser Ser Glu Tyr Arg His Ala Leu Glu Ser
     130                 135                 140

 gat atc gaa cca ttt aaa gac cac agt gca atc aaa cta gaa ctc agg      480
 Asp Ile Glu Pro Phe Lys Asp His Ser Ala Ile Lys Leu Glu Leu Arg
 145                 150                 155                 160

 att aag aat ctc act caa agc cgc tca act aca tgg aaa ctg aac aac      528
 Ile Lys Asn Leu Thr Gln Ser Arg Ser Thr Thr Trp Lys Leu Asn Asn
                 165                 170                 175

 ctg ctc ctg aat gac tac tgg gta cat aac gaa atg aag gca gaa ata      576
 Leu Leu Leu Asn Asp Tyr Trp Val His Asn Glu Met Lys Ala Glu Ile
             180                 185                 190

 aag atg ttc ttt gaa acc ggg tac cga gct aaa agt cgt atc aga gag      624
 Lys Met Phe Phe Glu Thr Gly Tyr Arg Ala Lys Ser Arg Ile Arg Glu
         195                 200                 205

 gca ggc agg cct cct tga                                              642
 Ala Gly Arg Pro Pro 
     210





      <210> 906
      <211> 1203
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (1)..(1203)

      <400> 906
  atg tcg gcg ctg gcg ggg gtg aaa agc gtg cag cag gtg ctg tgg ttt      48
  Met Ser Ala Leu Ala Gly Val Lys Ser Val Gln Gln Val Leu Trp Phe
    1               5                  10                  15

 gtc att ttg ccc ggt gcg ctg ccg gaa atc ctc acc gga tta cgt att       96
 Val Ile Leu Pro Gly Ala Leu Pro Glu Ile Leu Thr Gly Leu Arg Ile
              20                  25                  30

 ggt ctg ggg gtg ggc tgg tct acg ctg gtg gcg gcg gag ctg att gcc      144
 Gly Leu Gly Val Gly Trp Ser Thr Leu Val Ala Ala Glu Leu Ile Ala
          35                  40                  45

 gcg acg cgc ggt tta gga ttt atg gtt cag tca gcg ggt gaa ttt ctc      192
 Ala Thr Arg Gly Leu Gly Phe Met Val Gln Ser Ala Gly Glu Phe Leu
      50                  55                  60

 gca act gac gtg gtg ctg gcg ggg atc gcg gtg att gcg att atc gcc      240
 Ala Thr Asp Val Val Leu Ala Gly Ile Ala Val Ile Ala Ile Ile Ala
  65                  70                  75                  80

 ttt ctt tta gaa ctg ggt ctg cgc gcg tta cag cgc cgc ctg acg ccc      288
 Phe Leu Leu Glu Leu Gly Leu Arg Ala Leu Gln Arg Arg Leu Thr Pro
                  85                  90                  95

 ctg gca tgg aga agt aca atg agt gaa cgt ctg agc att acc ccg ctg      336
 Leu Ala Trp Arg Ser Thr Met Ser Glu Arg Leu Ser Ile Thr Pro Leu
             100                 105                 110

 ggg ccg tat atc ggc gca caa att tcg ggt gcc gac ctg acg cgc ccg      384
 Gly Pro Tyr Ile Gly Ala Gln Ile Ser Gly Ala Asp Leu Thr Arg Pro
         115                 120                 125

 tta agc gat aat cag ttt gaa cag ctt tac cat gcg gtg ctg cgc cat      432
 Leu Ser Asp Asn Gln Phe Glu Gln Leu Tyr His Ala Val Leu Arg His
     130                 135                 140

 cag gtg gtg ttt cta cgc gat caa gct att acg ccg cag cag caa cgc      480
 Gln Val Val Phe Leu Arg Asp Gln Ala Ile Thr Pro Gln Gln Gln Arg
 145                 150                 155                 160

 gcg ctg gcc cag cgt ttt ggc gaa ttg cat att cac cct gtt tac ccg      528
 Ala Leu Ala Gln Arg Phe Gly Glu Leu His Ile His Pro Val Tyr Pro
                 165                 170                 175

 cat gcc gaa ggg gtt gac gag atc atc gtg ctg gat acc cat aac gat      576
 His Ala Glu Gly Val Asp Glu Ile Ile Val Leu Asp Thr His Asn Asp
             180                 185                 190

 aat ccg cca gat aac gac aac tgg cat acc gat gtg aca ttt att gaa      624
 Asn Pro Pro Asp Asn Asp Asn Trp His Thr Asp Val Thr Phe Ile Glu
         195                 200                 205

 acg cca ccc gca ggg gcg att ctg gca gct aaa gag tta cct tcg acc      672
 Thr Pro Pro Ala Gly Ala Ile Leu Ala Ala Lys Glu Leu Pro Ser Thr
     210                 215                 220

 ggc ggt gat acg ctc tgg acc agc ggt att gcg gcc tat gag gcg ctc      720
 Gly Gly Asp Thr Leu Trp Thr Ser Gly Ile Ala Ala Tyr Glu Ala Leu
 225                 230                 235                 240

 tct gtt ccc ttc cgc cag ctg ctg agt ggg ctg cgt gcg gag cat gat      768
 Ser Val Pro Phe Arg Gln Leu Leu Ser Gly Leu Arg Ala Glu His Asp
                 245                 250                 255

 ttc cgt aaa tcg ttc ccg gaa tac aaa tac cgc aaa acc gag gag gaa      816
 Phe Arg Lys Ser Phe Pro Glu Tyr Lys Tyr Arg Lys Thr Glu Glu Glu
             260                 265                 270

 cat caa cgc tgg cgc gag gcg gtc gcg aaa aac ccg ccg ttg cta cat      864
 His Gln Arg Trp Arg Glu Ala Val Ala Lys Asn Pro Pro Leu Leu His
         275                 280                 285

 ccg gtg gtg cga acg cat ccg gtg agc ggt aaa cag gcg ctg ttt gtg      912
 Pro Val Val Arg Thr His Pro Val Ser Gly Lys Gln Ala Leu Phe Val
     290                 295                 300

 aat gaa ggc ttt act acg cga att gtt gat gtg agc gag aaa gag agc      960
 Asn Glu Gly Phe Thr Thr Arg Ile Val Asp Val Ser Glu Lys Glu Ser
 305                 310                 315                 320

 gaa gcc ttg tta agt ttt ttg ttt gcc cat atc acc aaa ccg gag ttt     1008
 Glu Ala Leu Leu Ser Phe Leu Phe Ala His Ile Thr Lys Pro Glu Phe
                 325                 330                 335

 cag gtg cgc tgg cgc tgg caa cca aat gat att gcg att tgg gat aac     1056
 Gln Val Arg Trp Arg Trp Gln Pro Asn Asp Ile Ala Ile Trp Asp Asn
             340                 345                 350

 cgc gtg acc cag cac tat gcc aat gcc gat tac ctg cca cag cga cgg     1104
 Arg Val Thr Gln His Tyr Ala Asn Ala Asp Tyr Leu Pro Gln Arg Arg
         355                 360                 365

 ata atg cat cgg gcg acg atc ctt ggg gat aaa ccg ttt tat cgg gcc     1152
 Ile Met His Arg Ala Thr Ile Leu Gly Asp Lys Pro Phe Tyr Arg Ala
     370                 375                 380

 ggg gta ata cga gag tgg acg gtc ccc tcg ccc ctt tgg gga gag ggt     1200
 Gly Val Ile Arg Glu Trp Thr Val Pro Ser Pro Leu Trp Gly Glu Gly
 385                 390                 395                 400

 tag                                                                 1203
 






      <210> 907
      <211> 591
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (1)..(591)

      <400> 907
  atg gaa ctg tgc atc ctc gcc ttc ggt ttt gcg ctg att gtt ggc atc      48
  Met Glu Leu Cys Ile Leu Ala Phe Gly Phe Ala Leu Ile Val Gly Ile
    1               5                  10                  15

 ccc gtg ggg atg att gcc ggg att acg cgc cat aag tgg cag gat aac       96
 Pro Val Gly Met Ile Ala Gly Ile Thr Arg His Lys Trp Gln Asp Asn
              20                  25                  30

 ttg atc aac gcc atc gcc tta ctg ggc ttt tca atc ccg gtg ttc tgg      144
 Leu Ile Asn Ala Ile Ala Leu Leu Gly Phe Ser Ile Pro Val Phe Trp
          35                  40                  45

 ctg gcg ctt ctg ttg acg ctg ttt tgt tca ctc acg cta ggt tgg ttg      192
 Leu Ala Leu Leu Leu Thr Leu Phe Cys Ser Leu Thr Leu Gly Trp Leu
      50                  55                  60

 ccc gtt tca ggg cgt ttc gat ctg ctc tac gaa gtg aaa ccg att acc      240
 Pro Val Ser Gly Arg Phe Asp Leu Leu Tyr Glu Val Lys Pro Ile Thr
  65                  70                  75                  80

 ggt ttt gcg ttg att gat gcc tgg ctt tcg gac tca cca tgg cgg gat      288
 Gly Phe Ala Leu Ile Asp Ala Trp Leu Ser Asp Ser Pro Trp Arg Asp
                  85                  90                  95

 gaa atg atc atg agc gca atc cgc cat atg ata ttg ccc gtg atc acc      336
 Glu Met Ile Met Ser Ala Ile Arg His Met Ile Leu Pro Val Ile Thr
             100                 105                 110

 ctg tcg gtt gcg cca aca act gaa gtg atc cgc ctg atg cgt atc agc      384
 Leu Ser Val Ala Pro Thr Thr Glu Val Ile Arg Leu Met Arg Ile Ser
         115                 120                 125

 act atc gaa gtg tat gac cag aac tat gta aaa gcg gcg gcg acc cgc      432
 Thr Ile Glu Val Tyr Asp Gln Asn Tyr Val Lys Ala Ala Ala Thr Arg
     130                 135                 140

 ggt ttg tcg cgc ttt act att ttg cgt cgc cac gtt ctg cat aac gcg      480
 Gly Leu Ser Arg Phe Thr Ile Leu Arg Arg His Val Leu His Asn Ala
 145                 150                 155                 160

 tta ccg ccg gtt att cct cgt ctg ggc tta cac ccc tcc acc atg ctg      528
 Leu Pro Pro Val Ile Pro Arg Leu Gly Leu His Pro Ser Thr Met Leu
                 165                 170                 175

 acg ctg gcg atg atc acc gaa atg gtt tta ggg ggt gct ttt gag tcg      576
 Thr Leu Ala Met Ile Thr Glu Met Val Leu Gly Gly Ala Phe Glu Ser
             180                 185                 190

 acc gaa ggc gag taa                                                  591
 Thr Glu Gly Glu 
         195





      <210> 908
      <211> 4596
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (1)..(4596)

      <400> 908
  atg gac gct ggc aaa gcg ggg cag acc ctg aag act cac tgc tca gcc      48
  Met Asp Ala Gly Lys Ala Gly Gln Thr Leu Lys Thr His Cys Ser Ala
    1               5                  10                  15

 cag cgc cca gat gtc tgc agg tgg ctg agc ccc ttc atc ctc tcc tgc       96
 Gln Arg Pro Asp Val Cys Arg Trp Leu Ser Pro Phe Ile Leu Ser Cys
              20                  25                  30

 tgc gtg tac ttc tgc ctc tgg att ccc gag gac cag ctg tcc tgg ttc      144
 Cys Val Tyr Phe Cys Leu Trp Ile Pro Glu Asp Gln Leu Ser Trp Phe
          35                  40                  45

 gct gcc ctg gtc aag tgc ctg ccc gtc ctc tgc ctg gct ggg ttc ctg      192
 Ala Ala Leu Val Lys Cys Leu Pro Val Leu Cys Leu Ala Gly Phe Leu
      50                  55                  60

 tgg gtc atg tcc cca agc ggg ggc tac acc cag ctc ctc cag gga gcc      240
 Trp Val Met Ser Pro Ser Gly Gly Tyr Thr Gln Leu Leu Gln Gly Ala
  65                  70                  75                  80

 ctt gtg tgc tcg gct gtg ggg gac gct tgc ctc atc tgg ccg gca gcc      288
 Leu Val Cys Ser Ala Val Gly Asp Ala Cys Leu Ile Trp Pro Ala Ala
                  85                  90                  95

 ttc gtc cct ggc atg gcc gcc ttt gcc acc gcc cac ctc ctc tac gtc      336
 Phe Val Pro Gly Met Ala Ala Phe Ala Thr Ala His Leu Leu Tyr Val
             100                 105                 110

 tgg gcc ttc ggc ttc tct ccc ctg cag ccc ggc ctg ctg ctg ctc atc      384
 Trp Ala Phe Gly Phe Ser Pro Leu Gln Pro Gly Leu Leu Leu Leu Ile
         115                 120                 125

 atc ctg gcc cct ggc ccc tac ctc agc ctt gtg ctc cag cac ctc gag      432
 Ile Leu Ala Pro Gly Pro Tyr Leu Ser Leu Val Leu Gln His Leu Glu
     130                 135                 140

 ccg gat atg gtc ctg ccg gtg gca gcc tat ggg ctg atc ctg atg gcc      480
 Pro Asp Met Val Leu Pro Val Ala Ala Tyr Gly Leu Ile Leu Met Ala
 145                 150                 155                 160

 atg ctg tgg cgc ggc ctg gcc cag ggc ggg agt gcc ggc tgg ggc gcg      528
 Met Leu Trp Arg Gly Leu Ala Gln Gly Gly Ser Ala Gly Trp Gly Ala
                 165                 170                 175

 ctg ctc ttc acg ctc tct gat ggc gtg ctg gcc tgg gac acc ttc gcc      576
 Leu Leu Phe Thr Leu Ser Asp Gly Val Leu Ala Trp Asp Thr Phe Ala
             180                 185                 190

 cag ccc ctg ccc cat gcc cac ctg gtg atc atg acc acc tac tat gct      624
 Gln Pro Leu Pro His Ala His Leu Val Ile Met Thr Thr Tyr Tyr Ala
         195                 200                 205

 gcc cag ctc ctc atc aca ctg tca gcc ctc agg agc ccg gcc ctc ggg      672
 Ala Gln Leu Leu Ile Thr Leu Ser Ala Leu Arg Ser Pro Ala Leu Gly
     210                 215                 220

 acc acg aca gag gcc aca gca gca gag gct tct acc cat gtc agc cgc      720
 Thr Thr Thr Glu Ala Thr Ala Ala Glu Ala Ser Thr His Val Ser Arg
 225                 230                 235                 240

 caa agc aga cag aat cgt gag tgt gga ggc tcg gac ctc cag ctc cat      768
 Gln Ser Arg Gln Asn Arg Glu Cys Gly Gly Ser Asp Leu Gln Leu His
                 245                 250                 255

 cac cct gag ctg ggc agc ccc aag ggc cca gac cgg cag act tcc atc      816
 His Pro Glu Leu Gly Ser Pro Lys Gly Pro Asp Arg Gln Thr Ser Ile
             260                 265                 270

 tac tgg gtc cag ggg cat ggc cag cgg gaa cac aag cac gtc aca ctg      864
 Tyr Trp Val Gln Gly His Gly Gln Arg Glu His Lys His Val Thr Leu
         275                 280                 285

 ctg gct cgt ggt gga ggg ctt cag cct ggg acc ctc tac acc acc tct      912
 Leu Ala Arg Gly Gly Gly Leu Gln Pro Gly Thr Leu Tyr Thr Thr Ser
     290                 295                 300

 gtg tgg gcc aag aag aaa gga gta ggt ggc ccc agg gac gtc ctg agc      960
 Val Trp Ala Lys Lys Lys Gly Val Gly Gly Pro Arg Asp Val Leu Ser
 305                 310                 315                 320

 atg tct aca ggc cca gac tcc aag acc tgc ccc tac tgg ctc tgc tgg     1008
 Met Ser Thr Gly Pro Asp Ser Lys Thr Cys Pro Tyr Trp Leu Cys Trp
                 325                 330                 335

 gcc agt gac tcc tca gac atc agg gtg cct gtg gag ggc ctg gct gca     1056
 Ala Ser Asp Ser Ser Asp Ile Arg Val Pro Val Glu Gly Leu Ala Ala
             340                 345                 350

 ggg acg cag tac ccc agc atg tgg gcc cag aag cat gag gtc aac agc     1104
 Gly Thr Gln Tyr Pro Ser Met Trp Ala Gln Lys His Glu Val Asn Ser
         355                 360                 365

 ccc agc cag acg ctc aca gag gcc acg ggc gag ggt ttg tac ctc cct     1152
 Pro Ser Gln Thr Leu Thr Glu Ala Thr Gly Glu Gly Leu Tyr Leu Pro
     370                 375                 380

 tcc cca aga gtg acc agt ctc ctg atc ttt atc atc tgc gag cat gga     1200
 Ser Pro Arg Val Thr Ser Leu Leu Ile Phe Ile Ile Cys Glu His Gly
 385                 390                 395                 400

 tct agg aga acc cca gct ctc tta caa gtt gat gag tca ggc ccc tgt     1248
 Ser Arg Arg Thr Pro Ala Leu Leu Gln Val Asp Glu Ser Gly Pro Cys
                 405                 410                 415

 cac ttc ctg gat ctt tca atc ctg gct gcc cgc aag gcc agg aag agc     1296
 His Phe Leu Asp Leu Ser Ile Leu Ala Ala Arg Lys Ala Arg Lys Ser
             420                 425                 430

 gaa aac aag ggc tgg att cag cgg aaa cac ggc aac aca gga cac agc     1344
 Glu Asn Lys Gly Trp Ile Gln Arg Lys His Gly Asn Thr Gly His Ser
         435                 440                 445

 cac agc ggc ctg tgc agc tgg aca ggg gcc agg gcg cct gcc ccc aac     1392
 His Ser Gly Leu Cys Ser Trp Thr Gly Ala Arg Ala Pro Ala Pro Asn
     450                 455                 460

 cca ggg agg aac ctg aca gtg gag act cag acc acc agc tcc atc tcc     1440
 Pro Gly Arg Asn Leu Thr Val Glu Thr Gln Thr Thr Ser Ser Ile Ser
 465                 470                 475                 480

 ctg agc tgg gag gtc ccc gat ggc cta gac tca cag aac tcc aac tac     1488
 Leu Ser Trp Glu Val Pro Asp Gly Leu Asp Ser Gln Asn Ser Asn Tyr
                 485                 490                 495

 tgg gtt cag tgt act gga gac ggc ggc aca aca gag act cga aac aca     1536
 Trp Val Gln Cys Thr Gly Asp Gly Gly Thr Thr Glu Thr Arg Asn Thr
             500                 505                 510

 aca gcc acc aac gtc acc gtg gat ggc ctt gga ccc ggg tca ttg tat     1584
 Thr Ala Thr Asn Val Thr Val Asp Gly Leu Gly Pro Gly Ser Leu Tyr
         515                 520                 525

 acg tgt tct gtg tgg gtg gag aaa gac gga gta aat agc tct gtg ggg     1632
 Thr Cys Ser Val Trp Val Glu Lys Asp Gly Val Asn Ser Ser Val Gly
     530                 535                 540

 act gtc act act gcc aca gct ccc aac cca gtg agg aac ctg aga gtg     1680
 Thr Val Thr Thr Ala Thr Ala Pro Asn Pro Val Arg Asn Leu Arg Val
 545                 550                 555                 560

 gag gct cag acc aac agc tcc atc gcc ctg acc tgg gag gtc ccc gac     1728
 Glu Ala Gln Thr Asn Ser Ser Ile Ala Leu Thr Trp Glu Val Pro Asp
                 565                 570                 575

 ggc cca gac cca cag aac tcc acc tac ggg gtt gag tac act gga gat     1776
 Gly Pro Asp Pro Gln Asn Ser Thr Tyr Gly Val Glu Tyr Thr Gly Asp
             580                 585                 590

 ggt ggc aga gca ggg act cga agc aca gca cac act aac atc acc gtg     1824
 Gly Gly Arg Ala Gly Thr Arg Ser Thr Ala His Thr Asn Ile Thr Val
         595                 600                 605

 gat gga ctt gaa ccc ggg tgt ttg tat gcg ttt tcc atg tgg gtg gga     1872
 Asp Gly Leu Glu Pro Gly Cys Leu Tyr Ala Phe Ser Met Trp Val Gly
     610                 615                 620

 aag aat gga atc aac agc tcc cgg gag act cga aat gcc acc aca gct     1920
 Lys Asn Gly Ile Asn Ser Ser Arg Glu Thr Arg Asn Ala Thr Thr Ala
 625                 630                 635                 640

 cac aac cca gtg agg aac ctg aga gtg gag gct cag acc acc agc tcc     1968
 His Asn Pro Val Arg Asn Leu Arg Val Glu Ala Gln Thr Thr Ser Ser
                 645                 650                 655

 atc tcc ctg agc tgg gag gtc ccc gat ggc aca gac cca cag aac tcg     2016
 Ile Ser Leu Ser Trp Glu Val Pro Asp Gly Thr Asp Pro Gln Asn Ser
             660                 665                 670

 acc tac tgc gtt cag tgc act gga gat ggt ggc aga aca gag act cga     2064
 Thr Tyr Cys Val Gln Cys Thr Gly Asp Gly Gly Arg Thr Glu Thr Arg
         675                 680                 685

 aac aca aca gac acc aga gtc acc gtg gat ggc ctt gga ccc ggg tca     2112
 Asn Thr Thr Asp Thr Arg Val Thr Val Asp Gly Leu Gly Pro Gly Ser
     690                 695                 700

 ttg tat acg tgt tct gtg tgg gtg gag aaa gac gga gta aat agc tct     2160
 Leu Tyr Thr Cys Ser Val Trp Val Glu Lys Asp Gly Val Asn Ser Ser
 705                 710                 715                 720

 gtg gag att gtc act agt gcc aca gct ccc aac cca gtg aga aac ctg     2208
 Val Glu Ile Val Thr Ser Ala Thr Ala Pro Asn Pro Val Arg Asn Leu
                 725                 730                 735

 aca gtg gag gct cag acc aac agc tcc atc gcc ctg acc tgg gag gtc     2256
 Thr Val Glu Ala Gln Thr Asn Ser Ser Ile Ala Leu Thr Trp Glu Val
             740                 745                 750

 ccc gat ggc cca gac cca cag aac tcc acc tac ggg gtt gag tac act     2304
 Pro Asp Gly Pro Asp Pro Gln Asn Ser Thr Tyr Gly Val Glu Tyr Thr
         755                 760                 765

 gga gat ggt ggc aga gca ggg act cga agc aca gca cac acc aac atc     2352
 Gly Asp Gly Gly Arg Ala Gly Thr Arg Ser Thr Ala His Thr Asn Ile
     770                 775                 780

 acc gtg gat aga ctt gaa ccc ggg tgt ttg tat gtg ttt tcc gtg tgg     2400
 Thr Val Asp Arg Leu Glu Pro Gly Cys Leu Tyr Val Phe Ser Val Trp
 785                 790                 795                 800

 gtg ggg aag aat gga atc aac agc tcc cgg gag act cga aat gcc acc     2448
 Val Gly Lys Asn Gly Ile Asn Ser Ser Arg Glu Thr Arg Asn Ala Thr
                 805                 810                 815

 aca gcc ccc aac cca gtg aga aac ctc cat atg gag act cag acc aac     2496
 Thr Ala Pro Asn Pro Val Arg Asn Leu His Met Glu Thr Gln Thr Asn
             820                 825                 830

 agc tcc atc gcc cta tgc tgg gaa gtc ccc gat ggc cca tac cct cag     2544
 Ser Ser Ile Ala Leu Cys Trp Glu Val Pro Asp Gly Pro Tyr Pro Gln
         835                 840                 845

 gac tac acc tac tgg gta gag tac act gga gac ggt ggt ggc aca gag     2592
 Asp Tyr Thr Tyr Trp Val Glu Tyr Thr Gly Asp Gly Gly Gly Thr Glu
     850                 855                 860

 acc cga aac aca aca aat acc agt gtg aca gct gag aga ctt gag ccc     2640
 Thr Arg Asn Thr Thr Asn Thr Ser Val Thr Ala Glu Arg Leu Glu Pro
 865                 870                 875                 880

 gga acc ttg tac aca ttc tct gta tgg gca gaa aaa aat gga gca cgt     2688
 Gly Thr Leu Tyr Thr Phe Ser Val Trp Ala Glu Lys Asn Gly Ala Arg
                 885                 890                 895

 ggc tcc agg cag aat gtc agc atc tcc aca gtc ccc aac gca gtg aca     2736
 Gly Ser Arg Gln Asn Val Ser Ile Ser Thr Val Pro Asn Ala Val Thr
             900                 905                 910

 agc ctc agc aag cag gac tgg acc aac agc acc att gct ttg cgc tgg     2784
 Ser Leu Ser Lys Gln Asp Trp Thr Asn Ser Thr Ile Ala Leu Arg Trp
         915                 920                 925

 aca gct ccc cag ggc cca ggc cag tct tcc tac agc tac tgg gtc tca     2832
 Thr Ala Pro Gln Gly Pro Gly Gln Ser Ser Tyr Ser Tyr Trp Val Ser
     930                 935                 940

 tgg gtc agg gaa ggc atg act gac ccc agg acc caa agc acc tca ggt     2880
 Trp Val Arg Glu Gly Met Thr Asp Pro Arg Thr Gln Ser Thr Ser Gly
 945                 950                 955                 960

 act gac atc acc cta aag gaa ctg gaa gct ggc agc ctg tac cac ctc     2928
 Thr Asp Ile Thr Leu Lys Glu Leu Glu Ala Gly Ser Leu Tyr His Leu
                 965                 970                 975

 acc gtc tgg gcc gag agg aat gag gtc aga ggc tat aac agc acc ctc     2976
 Thr Val Trp Ala Glu Arg Asn Glu Val Arg Gly Tyr Asn Ser Thr Leu
             980                 985                 990

 act gca gcc act gct ccc aat gag gtc aca gat ctc cag aat gaa act     3024
 Thr Ala Ala Thr Ala Pro Asn Glu Val Thr Asp Leu Gln Asn Glu Thr
         995                1000                1005

 cag act aag aac tca gtc atg ctg tgg tgg aag gcc cct gga gac ccc     3072
 Gln Thr Lys Asn Ser Val Met Leu Trp Trp Lys Ala Pro Gly Asp Pro
    1010                1015                1020

 cac tct cag ttg tac gta tac tgg gtc cag tgg gcc agc aag gga cat     3120
 His Ser Gln Leu Tyr Val Tyr Trp Val Gln Trp Ala Ser Lys Gly His
1025                1030                1035                1040

 ccc cgg agg ggg caa gat ccc caa gcg aat tgg gtc aac cag acc agc     3168
 Pro Arg Arg Gly Gln Asp Pro Gln Ala Asn Trp Val Asn Gln Thr Ser
                1045                1050                1055

 agg acc aat gag acg tgg tac aaa gtg gag gcc ctg gaa ccc ggg acg     3216
 Arg Thr Asn Glu Thr Trp Tyr Lys Val Glu Ala Leu Glu Pro Gly Thr
            1060                1065                1070

 ttg tac aat ttc acc gtg tgg gca gag agg aat gac gta gcc agt tcc     3264
 Leu Tyr Asn Phe Thr Val Trp Ala Glu Arg Asn Asp Val Ala Ser Ser
        1075                1080                1085

 acg cag agc ctc tgt gcg tcc aca tac cca gac aca gtc acc atc act     3312
 Thr Gln Ser Leu Cys Ala Ser Thr Tyr Pro Asp Thr Val Thr Ile Thr
    1090                1095                1100

 tcc tgt gtc agc acc tca gcg ggc tat gga gtc aac ttg atc tgg tcc     3360
 Ser Cys Val Ser Thr Ser Ala Gly Tyr Gly Val Asn Leu Ile Trp Ser
1105                1110                1115                1120

 tgc ccc cag gga ggc tac gag gcc ttt gag ttg gag gtg gga gga cag     3408
 Cys Pro Gln Gly Gly Tyr Glu Ala Phe Glu Leu Glu Val Gly Gly Gln
                1125                1130                1135

 cgg ggc tcc cag gac aga tct tca tgt ggg gag gct gtg tct gtg ttg     3456
 Arg Gly Ser Gln Asp Arg Ser Ser Cys Gly Glu Ala Val Ser Val Leu
            1140                1145                1150

 ggt ctc ggg ccg gct cgg tcc tac cca gcc acc atc acg acc atc tgg     3504
 Gly Leu Gly Pro Ala Arg Ser Tyr Pro Ala Thr Ile Thr Thr Ile Trp
        1155                1160                1165

 gac gga atg aag gtc gtg tct cac tct gtg gtc tgc cac acc gag agt     3552
 Asp Gly Met Lys Val Val Ser His Ser Val Val Cys His Thr Glu Ser
    1170                1175                1180

 gca ggg gtc att gcc gga gcc ttt gtg ggc atc ctc ctg ttt ctc atc     3600
 Ala Gly Val Ile Ala Gly Ala Phe Val Gly Ile Leu Leu Phe Leu Ile
1185                1190                1195                1200

 ctc gtg ggc ctg ctg att ttc ttc ctg aag agg agg aat aag aag aag     3648
 Leu Val Gly Leu Leu Ile Phe Phe Leu Lys Arg Arg Asn Lys Lys Lys
                1205                1210                1215

 cag cag aaa cca gaa ctc agg gat ctg gtc ttt agc tcc cca ggg gac     3696
 Gln Gln Lys Pro Glu Leu Arg Asp Leu Val Phe Ser Ser Pro Gly Asp
            1220                1225                1230

 atc cca gct gaa gac ttc gct gac cac gtc agg aag aat gag agg gac     3744
 Ile Pro Ala Glu Asp Phe Ala Asp His Val Arg Lys Asn Glu Arg Asp
        1235                1240                1245

 agc aac tgt ggt ttt gca gac aag tac cag caa ctc tcc ctg gtg ggc     3792
 Ser Asn Cys Gly Phe Ala Asp Lys Tyr Gln Gln Leu Ser Leu Val Gly
    1250                1255                1260

 cac agc cag tct cag atg gtg gct tcg gct tca gag aac aac gcc aag     3840
 His Ser Gln Ser Gln Met Val Ala Ser Ala Ser Glu Asn Asn Ala Lys
1265                1270                1275                1280

 aac cgc tac aga aat gtg ctg ccc tat gac tgg tcc cgg gtg ccc ctg     3888
 Asn Arg Tyr Arg Asn Val Leu Pro Tyr Asp Trp Ser Arg Val Pro Leu
                1285                1290                1295

 aag ccc atc cat gag gag cca ggc tct gac tac atc aat gcc agc ttc     3936
 Lys Pro Ile His Glu Glu Pro Gly Ser Asp Tyr Ile Asn Ala Ser Phe
            1300                1305                1310

 atg ccc aca gtg ggt gac ttc tgg cgc ctg gtg tgg gaa cag cag agc     3984
 Met Pro Thr Val Gly Asp Phe Trp Arg Leu Val Trp Glu Gln Gln Ser
        1315                1320                1325

 cac acc ctg gtc atg ctg acc aac tgc atg gag gcc ggc cgg gtg aag     4032
 His Thr Leu Val Met Leu Thr Asn Cys Met Glu Ala Gly Arg Val Lys
    1330                1335                1340

 tgt gag cat tac tgg cct ctg gac tcg cag ccc tgc acc cat ggg cac     4080
 Cys Glu His Tyr Trp Pro Leu Asp Ser Gln Pro Cys Thr His Gly His
1345                1350                1355                1360

 ctg cgg gta acc ctg gta ggt gag gaa gtg atg gag aac tgg acg gtg     4128
 Leu Arg Val Thr Leu Val Gly Glu Glu Val Met Glu Asn Trp Thr Val
                1365                1370                1375

 cgg gaa ctg ctg ctc ctc cag gtg gag gag cag aag aca ctg tct gtg     4176
 Arg Glu Leu Leu Leu Leu Gln Val Glu Glu Gln Lys Thr Leu Ser Val
            1380                1385                1390

 cgc caa ttc cac tac cag gcc tgg ccg gat cac ggc gtt ccc tcc tcc     4224
 Arg Gln Phe His Tyr Gln Ala Trp Pro Asp His Gly Val Pro Ser Ser
        1395                1400                1405

 cca gac acc ttg ctg gct ttc tgg agg atg ctt cgg cag tgg ctg gat     4272
 Pro Asp Thr Leu Leu Ala Phe Trp Arg Met Leu Arg Gln Trp Leu Asp
    1410                1415                1420

 cag acc atg gag gga ggc cca ccc att gtg cac tgc agt gct ggc gtg     4320
 Gln Thr Met Glu Gly Gly Pro Pro Ile Val His Cys Ser Ala Gly Val
1425                1430                1435                1440

 ggt cgc aca gga acc ctc att gcc ctg gac gtc ctg ctc cgg cag ctg     4368
 Gly Arg Thr Gly Thr Leu Ile Ala Leu Asp Val Leu Leu Arg Gln Leu
                1445                1450                1455

 cag tcc gag ggt ctc ctt ggg ccc ttc agc ttt gta agg aag atg aga     4416
 Gln Ser Glu Gly Leu Leu Gly Pro Phe Ser Phe Val Arg Lys Met Arg
            1460                1465                1470

 gag agt cgg ccg ttg atg gtg cag act gag gct cag tac gta ttc ctg     4464
 Glu Ser Arg Pro Leu Met Val Gln Thr Glu Ala Gln Tyr Val Phe Leu
        1475                1480                1485

 cat cag tgc atc ctg cgg ttc ctc caa cag tca gcc cag gcc cca gcc     4512
 His Gln Cys Ile Leu Arg Phe Leu Gln Gln Ser Ala Gln Ala Pro Ala
    1490                1495                1500

 gag aag gaa gtc ccg tat gag gat gtc gaa aac ctc atc tac gag aac     4560
 Glu Lys Glu Val Pro Tyr Glu Asp Val Glu Asn Leu Ile Tyr Glu Asn
1505                1510                1515                1520

 gtg gcc gcc atc cag gcc cac aag ttg gag gtc taa                     4596
 Val Ala Ala Ile Gln Ala His Lys Leu Glu Val 
                1525                1530





      <210> 909
      <211> 2160
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (325)..(2160)

      <400> 909
 cctctggccg atggctcctc caacccgtct ctgcatgaaa acttaaagca ggctgttttg     60

 ccacaccagc cggtagaggc ctctccttcc agcagtctgg ggagcctgag ccagggtgag    120

 aaggacgact gcagctcctc atccagcgtc cactcggcca ccagcgatga caggtttctc    180

 agccgcacct tcctccgggt gaacgccttc cctgaagtgc tggcctgcga gagtgagata    240

 attcctgttc tgcgagagtg cagaaaggat aagagagatg tgtatgatac acctagcaat    300

 gtcatagttg gctgtgaata tgtg   atg gct gct gtc atc ctc att atc aca     351
                              Met Ala Ala Val Ile Leu Ile Ile Thr
                                1               5

 acc acc acc aaa atc atc atc atc ttc att atc acc acc agt ttt att      399
 Thr Thr Thr Lys Ile Ile Ile Ile Phe Ile Ile Thr Thr Ser Phe Ile
  10                  15                  20                  25

 ttg tat cac cat cac cac cac tat tac tat cac agt tct ctt ctt cat      447
 Leu Tyr His His His His His Tyr Tyr Tyr His Ser Ser Leu Leu His
                  30                  35                  40

 cat gtc att gtt gtc atc acc ata aac acc atc atc ttt gct att gtc      495
 His Val Ile Val Val Ile Thr Ile Asn Thr Ile Ile Phe Ala Ile Val
              45                  50                  55

 acc act gac atc atc att ctt tgt ctt tac cac cat cat cat cat cct      543
 Thr Thr Asp Ile Ile Ile Leu Cys Leu Tyr His His His His His Pro
          60                  65                  70

 cat gac cgc tgt cat cac caa cac cat cac cat cct cat gtc ctc att      591
 His Asp Arg Cys His His Gln His His His His Pro His Val Leu Ile
      75                  80                  85

 acc atc atc atg agc atc att ttt atc att gtt gta att att ggc att      639
 Thr Ile Ile Met Ser Ile Ile Phe Ile Ile Val Val Ile Ile Gly Ile
  90                  95                 100                 105

 ctc att act acc atc acc gcc atc atc atc ttc att acc acc ata atc      687
 Leu Ile Thr Thr Ile Thr Ala Ile Ile Ile Phe Ile Thr Thr Ile Ile
                 110                 115                 120

 atc atc acc atc ctt att gcc atc acc acc acc aat gtt gca ggg cag      735
 Ile Ile Thr Ile Leu Ile Ala Ile Thr Thr Thr Asn Val Ala Gly Gln
             125                 130                 135

 gca agc tcc aga ata ggg ttt agc ctg gga gga tcc cat ttt gat cag      783
 Ala Ser Ser Arg Ile Gly Phe Ser Leu Gly Gly Ser His Phe Asp Gln
         140                 145                 150

 cag ggt tgt gat cag aaa aca agt cct gcc agt ctc cta cct cac ctt      831
 Gln Gly Cys Asp Gln Lys Thr Ser Pro Ala Ser Leu Leu Pro His Leu
     155                 160                 165

 atc ctc acc atc att gtc atc att att ctc gtt act act atc acc agc      879
 Ile Leu Thr Ile Ile Val Ile Ile Ile Leu Val Thr Thr Ile Thr Ser
 170                 175                 180                 185

 ctc tta ttc atc atc ccc tgc cat cat ttt cat tat cat cat cat tgt      927
 Leu Leu Phe Ile Ile Pro Cys His His Phe His Tyr His His His Cys
                 190                 195                 200

 tat tgt cat cat ttt cat tac tgc cat cgt cat cgc atc att gtt gtg      975
 Tyr Cys His His Phe His Tyr Cys His Arg His Arg Ile Ile Val Val
             205                 210                 215

 ata gtc ttc atc agc acc acc atc atc acc atc ttc atc agc acc acc     1023
 Ile Val Phe Ile Ser Thr Thr Ile Ile Thr Ile Phe Ile Ser Thr Thr
         220                 225                 230

 atc acc acc ttt atc atc ttt cct gct acc tct acc ttc acc ttc att     1071
 Ile Thr Thr Phe Ile Ile Phe Pro Ala Thr Ser Thr Phe Thr Phe Ile
     235                 240                 245

 aga gtc ctc att gtc atc gtc atc gtc ctt gtt cct acc act gat ttg     1119
 Arg Val Leu Ile Val Ile Val Ile Val Leu Val Pro Thr Thr Asp Leu
 250                 255                 260                 265

 gag gaa cta gaa aag gga ctt cag gtc aaa ctg tca aac aca gaa atg     1167
 Glu Glu Leu Glu Lys Gly Leu Gln Val Lys Leu Ser Asn Thr Glu Met
                 270                 275                 280

 tcg ggg gct ggt gac tct gag tac atc acc ctg gct gat gtg gaa aag     1215
 Ser Gly Ala Gly Asp Ser Glu Tyr Ile Thr Leu Ala Asp Val Glu Lys
             285                 290                 295

 aag gag aga gaa tac tct gaa cag cta atc gat aat atg gaa gct ttc     1263
 Lys Glu Arg Glu Tyr Ser Glu Gln Leu Ile Asp Asn Met Glu Ala Phe
         300                 305                 310

 tgg aaa cag atg gca aat atc cag cac ttt ctt gtg gac cag ttt aag     1311
 Trp Lys Gln Met Ala Asn Ile Gln His Phe Leu Val Asp Gln Phe Lys
     315                 320                 325

 tgt tcc agc tcc aaa gcc cga cag ctg atg atg act ctg acg gaa aga     1359
 Cys Ser Ser Ser Lys Ala Arg Gln Leu Met Met Thr Leu Thr Glu Arg
 330                 335                 340                 345

 atg att gca gcc gaa ggg cta ttg tgc gat tct cag gag ctg cag gct     1407
 Met Ile Ala Ala Glu Gly Leu Leu Cys Asp Ser Gln Glu Leu Gln Ala
                 350                 355                 360

 ctg gac gcc ctg gag agg acg atg ggg cgg gcg cac atg gca aaa gtg     1455
 Leu Asp Ala Leu Glu Arg Thr Met Gly Arg Ala His Met Ala Lys Val
             365                 370                 375

 att gag ttt ctg aag ctg caa gtc cag gag gag acc agg tgc cgg ctg     1503
 Ile Glu Phe Leu Lys Leu Gln Val Gln Glu Glu Thr Arg Cys Arg Leu
         380                 385                 390

 gct gcc atc tcc cac ggc ctg gag ctg ctg gct ggt gag ggg aag ctg     1551
 Ala Ala Ile Ser His Gly Leu Glu Leu Leu Ala Gly Glu Gly Lys Leu
     395                 400                 405

 tcc ggg cgg cag aag gag gag ctg ctc acg cag cag cac aag gcc ttc     1599
 Ser Gly Arg Gln Lys Glu Glu Leu Leu Thr Gln Gln His Lys Ala Phe
 410                 415                 420                 425

 tgg cag gag gca gag cgc ttc agc cgg gag ttt gtc cag cga ggc aaa     1647
 Trp Gln Glu Ala Glu Arg Phe Ser Arg Glu Phe Val Gln Arg Gly Lys
                 430                 435                 440

 gac ctg gtc acg gcg tct ctg gct cac cag gtg gag gga acg gca aaa     1695
 Asp Leu Val Thr Ala Ser Leu Ala His Gln Val Glu Gly Thr Ala Lys
             445                 450                 455

 ctc acg ctg gcc caa gag gag gaa cag aga agc ttc ctg gct gag gcc     1743
 Leu Thr Leu Ala Gln Glu Glu Glu Gln Arg Ser Phe Leu Ala Glu Ala
         460                 465                 470

 cag ccg act gct gac ccg gaa aag ttt ctc gag gct ttt cat gag gtc     1791
 Gln Pro Thr Ala Asp Pro Glu Lys Phe Leu Glu Ala Phe His Glu Val
     475                 480                 485

 ctg gag agg cag agg ctg atg cag tgt gac ctg gag gaa gag gag aat     1839
 Leu Glu Arg Gln Arg Leu Met Gln Cys Asp Leu Glu Glu Glu Glu Asn
 490                 495                 500                 505

 gtc aga gcc acc gag gct gtg gtt gca ctc tgc cag gag cag gct aaa     1887
 Val Arg Ala Thr Glu Ala Val Val Ala Leu Cys Gln Glu Gln Ala Lys
                 510                 515                 520

 atc ctc cat tgc cga ttg gag agc tgg ctg cgc cct cct ggc tgg gcg     1935
 Ile Leu His Cys Arg Leu Glu Ser Trp Leu Arg Pro Pro Gly Trp Ala
             525                 530                 535

 tcc ttg ggc cag agc ctg gac tgt tct gag ctc tgg ttt cct tct ctg     1983
 Ser Leu Gly Gln Ser Leu Asp Cys Ser Glu Leu Trp Phe Pro Ser Leu
         540                 545                 550

 tgc aat gga gac tgg gag ccc att tac ttt aaa ggc tgg gtg tgc cga     2031
 Cys Asn Gly Asp Trp Glu Pro Ile Tyr Phe Lys Gly Trp Val Cys Arg
     555                 560                 565

 gga gag cag gtc caa ggc cca gac ctg gca cat ggg agc atg atc tca     2079
 Gly Glu Gln Val Gln Gly Pro Asp Leu Ala His Gly Ser Met Ile Ser
 570                 575                 580                 585

 gga gat gtt gag ccc agt ggg gat gag ccc aga tct ggg tcc agg gtc     2127
 Gly Asp Val Glu Pro Ser Gly Asp Glu Pro Arg Ser Gly Ser Arg Val
                 590                 595                 600

 ctg ggt gtg aat ctc aac cac caa aat gaa tga                         2160
 Leu Gly Val Asn Leu Asn His Gln Asn Glu 
             605                 610





      <210> 910
      <211> 1599
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (1)..(1599)

      <400> 910
  atg cag tgg tca tgc att gaa gta gtg gtg tgc ata gag gag ctg gtc      48
  Met Gln Trp Ser Cys Ile Glu Val Val Val Cys Ile Glu Glu Leu Val
    1               5                  10                  15

 ctg ctt cca ggc tgt gct cag aat cct tgg agg aaa tgt aga gag acc       96
 Leu Leu Pro Gly Cys Ala Gln Asn Pro Trp Arg Lys Cys Arg Glu Thr
              20                  25                  30

 aaa tgc aga atc tgt gaa cca ttg gag ctg gta gtt tcc gtg gcc tcg      144
 Lys Cys Arg Ile Cys Glu Pro Leu Glu Leu Val Val Ser Val Ala Ser
          35                  40                  45

 gat gcg gaa tgt tgc tgt tct ccc ctc aat ttt aat gta tcc agg gat      192
 Asp Ala Glu Cys Cys Cys Ser Pro Leu Asn Phe Asn Val Ser Arg Asp
      50                  55                  60

 cct ctg cag aca att gca ggg atg atc ttg cca ggt ctt gcc tat tcc      240
 Pro Leu Gln Thr Ile Ala Gly Met Ile Leu Pro Gly Leu Ala Tyr Ser
  65                  70                  75                  80

 gaa aga cag cag tca gtt tcc ttg aga ggg agc ctt tca cgt gga aat      288
 Glu Arg Gln Gln Ser Val Ser Leu Arg Gly Ser Leu Ser Arg Gly Asn
                  85                  90                  95

 gaa tcc aga gcc cac acc cca acc agc ttc tat gga gct gtc aca ctc      336
 Glu Ser Arg Ala His Thr Pro Thr Ser Phe Tyr Gly Ala Val Thr Leu
             100                 105                 110

 agg gcc act gtg acc tgc cct gtc acc cag ggc cat aac cat gga cag      384
 Arg Ala Thr Val Thr Cys Pro Val Thr Gln Gly His Asn His Gly Gln
         115                 120                 125

 cca tgg gct ctg ccc aga gcc act gaa att att cca gct gat gcc tac      432
 Pro Trp Ala Leu Pro Arg Ala Thr Glu Ile Ile Pro Ala Asp Ala Tyr
     130                 135                 140

 agc cct cct cca gtt gtg aca gcc aaa cat gtt tcc aaa aat tgg cag      480
 Ser Pro Pro Pro Val Val Thr Ala Lys His Val Ser Lys Asn Trp Gln
 145                 150                 155                 160

 atg tct cct cat ggc aaa atc ttc cct ggt gga gaa cca cag ata tta      528
 Met Ser Pro His Gly Lys Ile Phe Pro Gly Gly Glu Pro Gln Ile Leu
                 165                 170                 175

 acg tgt agg ata ttc ccc agg att ata gag gaa agt gat gtt gca gcc      576
 Thr Cys Arg Ile Phe Pro Arg Ile Ile Glu Glu Ser Asp Val Ala Ala
             180                 185                 190

 act gac acc ccc gca tca cag aga tgt gat gtc agc aaa gga aat gtt      624
 Thr Asp Thr Pro Ala Ser Gln Arg Cys Asp Val Ser Lys Gly Asn Val
         195                 200                 205

 gaa act gtg aac ccc tgg agc tgg cag gtt ctg tgg tgt cag att tcg      672
 Glu Thr Val Asn Pro Trp Ser Trp Gln Val Leu Trp Cys Gln Ile Ser
     210                 215                 220

 aat aca gct gta tcc gat gcc ttc aat gtt aag gta cct agg atc tct      720
 Asn Thr Ala Val Ser Asp Ala Phe Asn Val Lys Val Pro Arg Ile Ser
 225                 230                 235                 240

 ctg cag aga tcg tca cag cgc tgt ctt caa ccg ctg gag ata gtc aca      768
 Leu Gln Arg Ser Ser Gln Arg Cys Leu Gln Pro Leu Glu Ile Val Thr
                 245                 250                 255

 act ttc ctg caa gtg tgc ctt tca tgg gta aac caa cca gtc cta gct      816
 Thr Phe Leu Gln Val Cys Leu Ser Trp Val Asn Gln Pro Val Leu Ala
             260                 265                 270

 tac acc ccc agc cac acc tta tgg agc tct gag cca caa tcc acg tgc      864
 Tyr Thr Pro Ser His Thr Leu Trp Ser Ser Glu Pro Gln Ser Thr Cys
         275                 280                 285

 aca gtc acc caa ggt gat tcc ccg tgt agc tcc cct ggc tgt gct gtg      912
 Thr Val Thr Gln Gly Asp Ser Pro Cys Ser Ser Pro Gly Cys Ala Val
     290                 295                 300

 ccc tcg act tgt gat tat gag caa caa act ttc ctt tta atg gca gca      960
 Pro Ser Thr Cys Asp Tyr Glu Gln Gln Thr Phe Leu Leu Met Ala Ala
 305                 310                 315                 320

 ggc ccc agg aca gcc agt ggc tgt gtc atc atg atc tgc ttt gcc ctc     1008
 Gly Pro Arg Thr Ala Ser Gly Cys Val Ile Met Ile Cys Phe Ala Leu
                 325                 330                 335

 act gtc ctc tct tac atc cgc atc ttg gcc aca gtg gtt cag atc cgt     1056
 Thr Val Leu Ser Tyr Ile Arg Ile Leu Ala Thr Val Val Gln Ile Arg
             340                 345                 350

 tca gca gcc agc cgc cgg aag gcc ttc tcc acc tgt tct tcc cac ctg     1104
 Ser Ala Ala Ser Arg Arg Lys Ala Phe Ser Thr Cys Ser Ser His Leu
         355                 360                 365

 ggc atg gtg ctc ctg ttc tat ggc acc ggc agc tcc acc tac atg cga     1152
 Gly Met Val Leu Leu Phe Tyr Gly Thr Gly Ser Ser Thr Tyr Met Arg
     370                 375                 380

 ccc acc acc cgc tac tcc ccg ctg gaa ggg cgc ttg gct gct gtc ttc     1200
 Pro Thr Thr Arg Tyr Ser Pro Leu Glu Gly Arg Leu Ala Ala Val Phe
 385                 390                 395                 400

 tac tcc atc ctc ata ccc acc ctg aat ccg ctc atc tac agc ctg agg     1248
 Tyr Ser Ile Leu Ile Pro Thr Leu Asn Pro Leu Ile Tyr Ser Leu Arg
                 405                 410                 415

 aac cag gac atg aag aga gcc ctg tgg aag ctc tat ctc cag gtc ctc     1296
 Asn Gln Asp Met Lys Arg Ala Leu Trp Lys Leu Tyr Leu Gln Val Leu
             420                 425                 430

 cac gat cgg acc cca ccc agc tct gca gcc tcc tct atc acg ctc tct     1344
 His Asp Arg Thr Pro Pro Ser Ser Ala Ala Ser Ser Ile Thr Leu Ser
         435                 440                 445

 cct gca gct ttt att ccc agc tat gct ggc ctt agc tca gtt ctt caa     1392
 Pro Ala Ala Phe Ile Pro Ser Tyr Ala Gly Leu Ser Ser Val Leu Gln
     450                 455                 460

 gca aac cat tct tct ccc tac ctc ggg gct ctg cac ttg ctc ttc cgt     1440
 Ala Asn His Ser Ser Pro Tyr Leu Gly Ala Leu His Leu Leu Phe Arg
 465                 470                 475                 480

 cag ctg aaa tac cct tcc cca aat ctg agc atc acc gcc tct gca tat     1488
 Gln Leu Lys Tyr Pro Ser Pro Asn Leu Ser Ile Thr Ala Ser Ala Tyr
                 485                 490                 495

 ctg agc ttc att cta gac gtc gtc tct ttg gaa aga cct ctc cta acc     1536
 Leu Ser Phe Ile Leu Asp Val Val Ser Leu Glu Arg Pro Leu Leu Thr
             500                 505                 510

 act tct tta agt ggc atc atc ccc tcc ccc tct cgc aca tcc ccc cgt     1584
 Thr Ser Leu Ser Gly Ile Ile Pro Ser Pro Ser Arg Thr Ser Pro Arg
         515                 520                 525

 ttt att gct ttc tga                                                 1599
 Phe Ile Ala Phe 
     530





      <210> 911
      <211> 2145
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (1)..(2145)

      <400> 911
  atg gct gca gtg ctg gct ctc agg gtg gtc gcg ggg ttg gcg gcc gca      48
  Met Ala Ala Val Leu Ala Leu Arg Val Val Ala Gly Leu Ala Ala Ala
    1               5                  10                  15

 gcg ctg gtg gcc atg ctc ttg gag cac tac ggc ctg gcg ggc cag ccc       96
 Ala Leu Val Ala Met Leu Leu Glu His Tyr Gly Leu Ala Gly Gln Pro
              20                  25                  30

 tcg ccg ctg ccg cgc ccc gcg ccc ccc agg agg ccg cac cct gcg cca      144
 Ser Pro Leu Pro Arg Pro Ala Pro Pro Arg Arg Pro His Pro Ala Pro
          35                  40                  45

 ggg ccc gga gac agc aac atc ttc tgg ggc ctg cag atc tct ctg ttc      192
 Gly Pro Gly Asp Ser Asn Ile Phe Trp Gly Leu Gln Ile Ser Leu Phe
      50                  55                  60

 aat acc tgt ttt cgg cag ata tcc gac att cac ctg agc agg ttt cga      240
 Asn Thr Cys Phe Arg Gln Ile Ser Asp Ile His Leu Ser Arg Phe Arg
  65                  70                  75                  80

 gat cca ggc aga gcg gta gac tta gag aaa ttc tgt tct gaa act att      288
 Asp Pro Gly Arg Ala Val Asp Leu Glu Lys Phe Cys Ser Glu Thr Ile
                  85                  90                  95

 gac atc att caa cca gct ctc gtc cta gca aca gga gac ctg aca gat      336
 Asp Ile Ile Gln Pro Ala Leu Val Leu Ala Thr Gly Asp Leu Thr Asp
             100                 105                 110

 gcc aaa aca aag gaa cag ttg gga tcc agg cag cat gag gta gaa tgg      384
 Ala Lys Thr Lys Glu Gln Leu Gly Ser Arg Gln His Glu Val Glu Trp
         115                 120                 125

 caa acc tac cag ggt att ctg aag aag aca aga gtc atg gaa aaa acc      432
 Gln Thr Tyr Gln Gly Ile Leu Lys Lys Thr Arg Val Met Glu Lys Thr
     130                 135                 140

 aag tgg ctg gat atc aaa gga aat cat gat ttt gcg cgc caa ccc cag      480
 Lys Trp Leu Asp Ile Lys Gly Asn His Asp Phe Ala Arg Gln Pro Gln
 145                 150                 155                 160

 aaa gat gac tgg ggg cag ggg agc tgc gta ctg ttc aat gag acc cat      528
 Lys Asp Asp Trp Gly Gln Gly Ser Cys Val Leu Phe Asn Glu Thr His
                 165                 170                 175

 aac gtg gct gta act gtc ttc cta tta ttg caa gaa cat ggc cgg cag      576
 Asn Val Ala Val Thr Val Phe Leu Leu Leu Gln Glu His Gly Arg Gln
             180                 185                 190

 atc cag ctc ctc ata tac tgc ctt cac cgg ggc cac ctt ctc ggc ctc      624
 Ile Gln Leu Leu Ile Tyr Cys Leu His Arg Gly His Leu Leu Gly Leu
         195                 200                 205

 ctt ctg ccc aaa att ctc ctt cag aat ctg gta ctg ttc tgg agt ggc      672
 Leu Leu Pro Lys Ile Leu Leu Gln Asn Leu Val Leu Phe Trp Ser Gly
     210                 215                 220

 ccg ttg cag aca ctg aac cac cag cca gct gca ttt gtt gtc ctg gat      720
 Pro Leu Gln Thr Leu Asn His Gln Pro Ala Ala Phe Val Val Leu Asp
 225                 230                 235                 240

 gtc agt gcc aac ttt ggc ggt cac att ggg gtc ccc aaa gag cta cag      768
 Val Ser Ala Asn Phe Gly Gly His Ile Gly Val Pro Lys Glu Leu Gln
                 245                 250                 255

 gaa ggt aga agg agt aga aac tgc ctt gta cgt gac act aga ttt gta      816
 Glu Gly Arg Arg Ser Arg Asn Cys Leu Val Arg Asp Thr Arg Phe Val
             260                 265                 270

 cct ctt ttc agt gaa tct gcc aag atc cac att gcc ctg ggg ggc tat      864
 Pro Leu Phe Ser Glu Ser Ala Lys Ile His Ile Ala Leu Gly Gly Tyr
         275                 280                 285

 gat gag atc cag ggt ctg ccc aat ctc agt ctg ata gaa act ctg ccg      912
 Asp Glu Ile Gln Gly Leu Pro Asn Leu Ser Leu Ile Glu Thr Leu Pro
     290                 295                 300

 gaa gag ctg gat cag gtt cag aaa aag atg gag gag ctc tta tta ctg      960
 Glu Glu Leu Asp Gln Val Gln Lys Lys Met Glu Glu Leu Leu Leu Leu
 305                 310                 315                 320

 gcc aag gaa agc agt cgg agc aac cat aca att tgg ttt gga cac ttt     1008
 Ala Lys Glu Ser Ser Arg Ser Asn His Thr Ile Trp Phe Gly His Phe
                 325                 330                 335

 aca aca tcc act att ctt tct cca tca cca gga atc cgg tca ata atg     1056
 Thr Thr Ser Thr Ile Leu Ser Pro Ser Pro Gly Ile Arg Ser Ile Met
             340                 345                 350

 agg tac cgg att ttt gct ttt gat cac gac ctc ttt agc ttt gca gat     1104
 Arg Tyr Arg Ile Phe Ala Phe Asp His Asp Leu Phe Ser Phe Ala Asp
         355                 360                 365

 ttg atc ttt ggg aag tgg cct gtg gtt ctt atc acc aat cct aaa tca     1152
 Leu Ile Phe Gly Lys Trp Pro Val Val Leu Ile Thr Asn Pro Lys Ser
     370                 375                 380

 ctc ctt tat agt tgt ggt gaa cat gaa cca cta gaa aga ctt ctt cac     1200
 Leu Leu Tyr Ser Cys Gly Glu His Glu Pro Leu Glu Arg Leu Leu His
 385                 390                 395                 400

 tca aca cac atc aga gtc ttg gcc ttt tcc tta tcc tcc att act tct     1248
 Ser Thr His Ile Arg Val Leu Ala Phe Ser Leu Ser Ser Ile Thr Ser
                 405                 410                 415

 gtc aca gtt aag att gat gga gtt cat tta ggc cag gct gtt cat gtg     1296
 Val Thr Val Lys Ile Asp Gly Val His Leu Gly Gln Ala Val His Val
             420                 425                 430

 tct ggt ccc att ttc gta ctg aag tgg aat cct aga aac tac agt agt     1344
 Ser Gly Pro Ile Phe Val Leu Lys Trp Asn Pro Arg Asn Tyr Ser Ser
         435                 440                 445

 ggg aca cat aac ata gaa gta atc gtc cag gat tct gct gga aga agt     1392
 Gly Thr His Asn Ile Glu Val Ile Val Gln Asp Ser Ala Gly Arg Ser
     450                 455                 460

 aag agt gtt cac cac ata ttt tct gtt caa gag aat aat cat ctc agt     1440
 Lys Ser Val His His Ile Phe Ser Val Gln Glu Asn Asn His Leu Ser
 465                 470                 475                 480

 ttt gat ccc ctg gca tca ttt att ctc cgt act gat cac tac atc atg     1488
 Phe Asp Pro Leu Ala Ser Phe Ile Leu Arg Thr Asp His Tyr Ile Met
                 485                 490                 495

 gct tta gtg gat tcc agt gac ggt cca gga tct tac ttt gag aaa caa     1536
 Ala Leu Val Asp Ser Ser Asp Gly Pro Gly Ser Tyr Phe Glu Lys Gln
             500                 505                 510

 gca cct agg tca tat gtc act att gtg aat tca tct cca gcc ata tct     1584
 Ala Pro Arg Ser Tyr Val Thr Ile Val Asn Ser Ser Pro Ala Ile Ser
         515                 520                 525

 gta caa ggg ggt gcc cca agc cca gta ata ctg caa ctc ttg cag cct     1632
 Val Gln Gly Gly Ala Pro Ser Pro Val Ile Leu Gln Leu Leu Gln Pro
     530                 535                 540

 tac gtg ggc ttg gtg ggc ttg gag ggg gat ttg gca gga tca cag gac     1680
 Tyr Val Gly Leu Val Gly Leu Glu Gly Asp Leu Ala Gly Ser Gln Asp
 545                 550                 555                 560

 aat agt gga ggg aag agg aag gag tct ctc ttt gag ctg cac tgc ctg     1728
 Asn Ser Gly Gly Lys Arg Lys Glu Ser Leu Phe Glu Leu His Cys Leu
                 565                 570                 575

 gag agt tgg ggg atg ggt gac aca agt act ccc ctg gcc acc aca act     1776
 Glu Ser Trp Gly Met Gly Asp Thr Ser Thr Pro Leu Ala Thr Thr Thr
             580                 585                 590

 ggt gtc tca ctg ggt ctt gtg cac tcc att tcc act ggc tct gag ccc     1824
 Gly Val Ser Leu Gly Leu Val His Ser Ile Ser Thr Gly Ser Glu Pro
         595                 600                 605

 aac ata gta ccc aga ttt gcc caa gga ctg cag tcc ttg tgg ctt gac     1872
 Asn Ile Val Pro Arg Phe Ala Gln Gly Leu Gln Ser Leu Trp Leu Asp
     610                 615                 620

 tgc ctt tca agt tta ttc agg acc cta ggg cac ttg ttt agt cag ctg     1920
 Cys Leu Ser Ser Leu Phe Arg Thr Leu Gly His Leu Phe Ser Gln Leu
 625                 630                 635                 640

 gtg ctg gag cta gct gga act cag gtt cct acc act ggg gca gag gat     1968
 Val Leu Glu Leu Ala Gly Thr Gln Val Pro Thr Thr Gly Ala Glu Asp
                 645                 650                 655

 tgc cct ctg gca agg gcc agc tta aat gct ccc tct gtg ggt gct ggc     2016
 Cys Pro Leu Ala Arg Ala Ser Leu Asn Ala Pro Ser Val Gly Ala Gly
             660                 665                 670

 aga att ctg ccc tgt gtt gtg ttc ccc tgt gac agc act gag ttc caa     2064
 Arg Ile Leu Pro Cys Val Val Phe Pro Cys Asp Ser Thr Glu Phe Gln
         675                 680                 685

 cgc aaa gtc tca cag tca ttt tgc tct ctc cca caa gtg cac aga tta     2112
 Arg Lys Val Ser Gln Ser Phe Cys Ser Leu Pro Gln Val His Arg Leu
     690                 695                 700

 tct ctg cca cag aat ggg gga agg gtg gtg tag                         2145
 Ser Leu Pro Gln Asn Gly Gly Arg Val Val 
 705                 710



      <210> 912
      <211> 568
      <212> PRT
      <213> Homo sapiens


      <400> 912
 Met Leu Ala Ala Thr Leu Ala Glu Leu Asp Gly Cys Leu Gln Leu Leu
   1               5                  10                  15    
 Glu Asp Lys Phe Leu Arg Asp Gln Ala Phe Leu Thr Gly Pro Arg Ile
              20                  25                  30        
 Ser Val Ala Gly Leu Val Ala Ile Thr Glu Leu Arg His Glu Ser Ala
          35                  40                  45            
 Met Gly Pro Ser Val Leu Ala Ala Glu Ser Leu Lys Ala Asp Pro Arg
      50                  55                  60                
 Trp Gln His Gly Ala Gln His Val Glu Ala Ala Val Arg Glu Asp Leu
  65                  70                  75                  80
 Phe Gln Glu Ala Leu Pro Ala Val Leu Lys Ala Lys Asp Leu Pro Pro
                  85                  90                  95    
 Val Glu Pro Ala Val Lys Glu Asn Leu Lys Thr Leu Met Gln Leu Phe
             100                 105                 110        
 Leu Leu Ala Val Ser Val Pro Leu Pro Ala Met Pro Phe Leu Glu Leu
         115                 120                 125            
 Asp Thr Asn Leu Pro Ala Asn Arg Val Pro Ala Gly Leu Glu Lys Arg
     130                 135                 140                
 Leu Cys Ala Ala Ala Ala Ser Ile Leu Gly Lys Pro Ala Asp Arg Val
 145                 150                 155                 160
 Asn Val Thr Val Arg Pro Gly Leu Ala Met Ala Leu Ser Gly Ser Thr
                 165                 170                 175    
 Glu Pro Cys Ala Gln Leu Ser Ile Ser Ser Ile Gly Val Val Gly Thr
             180                 185                 190        
 Ala Glu Asp Asn Arg Ser His Ser Ala His Phe Phe Glu Phe Leu Thr
         195                 200                 205            
 Lys Glu Leu Ala Leu Gly Gln Asp Arg Phe Ala Gln Asp Gly Gly Ser
     210                 215                 220                
 Gly Gly Ala Glu Ser Phe Leu Gln Pro Arg Gly His Ser Val Gly Gly
 225                 230                 235                 240
 Gln Ile Arg Val Gln Leu Gln Glu Arg His Gly Gly Gln Arg Asn Gly
                 245                 250                 255    
 Asn Ser Ser Gly Gly Arg Lys Ala Gly Gly Arg Val Ser Thr Cys Phe
             260                 265                 270        
 Met Leu Ser His Thr Gln Gly Ala Thr Pro Val Leu Gly Thr Gly Gly
         275                 280                 285            
 Trp Gly Leu Ile Pro Tyr Phe Pro Ala Arg Arg Asp Pro Ala Thr Ala
     290                 295                 300                
 Ala Ala His Thr Ala Leu Ser Ala Phe Thr Ala Ile Pro Ala Val Leu
 305                 310                 315                 320
 Ala Ala Pro Ala Met Gly Leu Glu Leu Phe Leu Asp Leu Val Ser Gln
                 325                 330                 335    
 Pro Ser Arg Ala Val Tyr Ile Phe Ala Lys Lys Asn Gly Ile Pro Leu
             340                 345                 350        
 Glu Leu Arg Thr Val Asp Leu Val Lys Gly Gln His Lys Ser Lys Glu
         355                 360                 365            
 Phe Leu Gln Ile Asn Ser Leu Gly Lys Leu Pro Thr Leu Lys Asp Gly
     370                 375                 380                
 Asp Phe Ile Leu Thr Glu Ser Ser Ala Ile Leu Ile Tyr Leu Ser Cys
 385                 390                 395                 400
 Lys Tyr Gln Thr Pro Asp His Trp Tyr Pro Ser Asp Leu Gln Ala Arg
                 405                 410                 415    
 Ala Arg Val His Glu Tyr Leu Gly Trp His Ala Asp Cys Ile Arg Gly
             420                 425                 430        
 Thr Phe Gly Ile Pro Leu Trp Val Gln Val Leu Gly Pro Leu Ile Gly
         435                 440                 445            
 Val Gln Val Pro Glu Glu Lys Val Glu Arg Asn Arg Thr Ala Met Asp
     450                 455                 460                
 Gln Ala Leu Gln Trp Leu Glu Asp Lys Phe Leu Gly Asp Arg Pro Phe
 465                 470                 475                 480
 Leu Ala Gly Gln Gln Val Thr Leu Ala Asp Leu Met Ala Leu Glu Glu
                 485                 490                 495    
 Leu Met Gln Pro Val Ala Leu Gly Tyr Glu Leu Phe Glu Gly Arg Pro
             500                 505                 510        
 Arg Leu Ala Ala Trp Arg Gly Arg Val Glu Ala Phe Leu Gly Ala Glu
         515                 520                 525            
 Leu Cys Gln Glu Ala His Ser Ile Ile Leu Ser Ile Leu Glu Gln Ala
     530                 535                 540                
 Ala Lys Lys Thr Leu Pro Thr Pro Ser Pro Glu Ala Tyr Gln Ala Met
 545                 550                 555                 560
 Leu Leu Arg Ile Ala Arg Ile Pro
                 565            



      <210> 913
      <211> 1001
      <212> PRT
      <213> Homo sapiens


      <400> 913
 Met Glu His Gly Ala Leu Gly Ser Leu Gly Glu His Ala Ala Lys Val
   1               5                  10                  15    
 Val Gly Lys Val Leu Arg Gln Glu Gln Asp Phe Val Ile Thr His His
              20                  25                  30        
 Gln Arg Leu Val Gly Pro Thr Val Met Glu Gln Lys His Arg Cys Lys
          35                  40                  45            
 Phe Ala Met Lys Glu Ile Val Gln Phe Met Ala Ser Gly Arg Leu Gly
      50                  55                  60                
 Pro Val Gly Val Pro Val Leu Cys His Val Glu Glu Val Pro Asp Arg
  65                  70                  75                  80
 Glu Gln Gly Ala Ala Pro Thr Leu Cys Pro Ser Met Glu Glu Gly Asn
                  85                  90                  95    
 Ala Lys Gly Val Met Ser Arg Val Ile Phe Ala Thr Val Thr Leu Ala
             100                 105                 110        
 Gln Val Ser Val Gly Asn Thr His Gly Asn Trp Ser Pro Trp Ser Gly
         115                 120                 125            
 Trp Gly Thr Cys Ser Arg Thr Cys Asn Gly Gly Gln Met Arg Arg Tyr
     130                 135                 140                
 Arg Thr Cys Asp Asn Pro Pro Pro Ser Asn Gly Gly Arg Ala Cys Gly
 145                 150                 155                 160
 Gly Pro Asp Ser Gln Ile Gln Arg Cys Asn Thr Asp Met Cys Pro Val
                 165                 170                 175    
 Asp Gly Ser Trp Gly Ser Trp His Ser Trp Ser Gln Cys Ser Ala Ser
             180                 185                 190        
 Cys Gly Gly Gly Glu Lys Thr Arg Lys Arg Leu Cys Asp His Pro Val
         195                 200                 205            
 Pro Val Lys Gly Gly Arg Pro Cys Pro Gly Asp Thr Thr Gln Val Thr
     210                 215                 220                
 Arg Cys Asn Val Gln Ala Cys Pro Gly Gly Pro Gln Arg Ala Arg Gly
 225                 230                 235                 240
 Ser Val Ile Gly Asn Ile Asn Asp Val Glu Phe Gly Ile Ala Phe Leu
                 245                 250                 255    
 Asn Ala Thr Ile Thr Asp Ser Pro Asn Ser Asp Thr Arg Ile Ile Arg
             260                 265                 270        
 Ala Lys Ile Thr Asn Val Pro Arg Ser Leu Gly Ser Ala Met Arg Lys
         275                 280                 285            
 Ile Val Ser Ile Leu Asn Pro Ile Tyr Trp Thr Thr Ala Lys Glu Ile
     290                 295                 300                
 Gly Glu Ala Val Asn Gly Phe Thr Leu Thr Asn Ala Val Phe Lys Arg
 305                 310                 315                 320
 Glu Thr Gln Val Glu Phe Ala Thr Gly Glu Ile Leu Gln Met Ser His
                 325                 330                 335    
 Ile Ala Arg Gly Leu Asp Ser Asp Gly Ser Leu Leu Leu Asp Ile Val
             340                 345                 350        
 Val Ser Gly Tyr Val Leu Gln Leu Gln Ser Pro Ala Glu Val Thr Val
         355                 360                 365            
 Lys Asp Tyr Thr Glu Asp Tyr Ile Gln Thr Gly Pro Gly Gln Leu Tyr
     370                 375                 380                
 Ala Tyr Ser Thr Arg Leu Phe Thr Ile Asp Gly Ile Ser Ile Pro Tyr
 385                 390                 395                 400
 Thr Trp Asn His Thr Val Phe Tyr Asp Gln Ala Gln Gly Arg Met Pro
                 405                 410                 415    
 Phe Leu Val Glu Thr Leu His Ala Ser Ser Val Glu Ser Asp Tyr Asn
             420                 425                 430        
 Gln Ile Glu Glu Thr Leu Gly Phe Lys Ile His Ala Ser Ile Ser Lys
         435                 440                 445            
 Gly Asp Arg Ser Asn Gln Cys Pro Ser Gly Phe Thr Leu Asp Ser Val
     450                 455                 460                
 Gly Pro Phe Cys Ala Asp Glu Asp Glu Cys Ala Ala Gly Asn Pro Cys
 465                 470                 475                 480
 Ser His Ser Cys His Asn Ala Met Gly Thr Tyr Tyr Cys Ser Cys Pro
                 485                 490                 495    
 Lys Gly Leu Thr Ile Ala Ala Asp Gly Arg Thr Cys Gln Asp Ile Asp
             500                 505                 510        
 Glu Cys Ala Leu Gly Arg His Thr Cys His Ala Gly Gln Asp Cys Asp
         515                 520                 525            
 Asn Thr Ile Gly Ser Tyr Arg Cys Val Val Arg Cys Gly Ser Gly Phe
     530                 535                 540                
 Arg Arg Thr Ser Asp Gly Leu Ser Cys Gln Asp Ile Asn Glu Cys Gln
 545                 550                 555                 560
 Glu Ser Ser Pro Cys His Gln Arg Cys Phe Asn Ala Ile Gly Ser Phe
                 565                 570                 575    
 His Cys Gly Cys Glu Pro Gly Tyr Gln Leu Lys Gly Arg Lys Cys Met
             580                 585                 590        
 Asp Val Asn Glu Cys Arg Gln Asn Val Cys Arg Pro Asp Gln His Cys
         595                 600                 605            
 Lys Asn Thr Arg Gly Gly Tyr Lys Cys Ile Asp Leu Cys Pro Asn Gly
     610                 615                 620                
 Met Thr Lys Ala Glu Asn Gly Thr Cys Ile Gly Glu Cys Leu Ala Val
 625                 630                 635                 640
 Ser Val Thr Glu Ile Ser Leu Pro Ser Thr Ser Gln Ile Leu Met Asn
                 645                 650                 655    
 Val Lys Met Gly Pro Ile Ser Ala Asp Ile Thr Arg Tyr Val Arg Ile
             660                 665                 670        
 Gln Glu Ala Ala Ile Val Val Tyr Ala Gln Glu Val Ile Gly Leu Lys
         675                 680                 685            
 Glu Leu Glu Asp Pro Ala Trp Cys Ser Asn Thr Pro Gly Ser Phe Lys
     690                 695                 700                
 Cys Ile Cys Pro Pro Gly Gln His Leu Leu Gly Asp Gly Lys Ser Cys
 705                 710                 715                 720
 Ala Gly Leu Glu Arg Leu Pro Asn Tyr Gly Thr Gln Tyr Ser Ser Tyr
                 725                 730                 735    
 Asn Leu Ala Arg Phe Ser Pro Val Arg Asn Asn Tyr Gln Pro Gln Gln
             740                 745                 750        
 His Tyr Arg Gln Tyr Ser His Leu Tyr Ser Ser Tyr Ser Glu Tyr Arg
         755                 760                 765            
 Asn Ser Arg Thr Ser Leu Ser Arg Thr Arg Arg Thr Ile Arg Lys Thr
     770                 775                 780                
 Cys Pro Glu Gly Ser Glu Ala Ser His Asp Thr Cys Val Asp Ile Asp
 785                 790                 795                 800
 Glu Cys Glu Asn Thr Asp Ala Cys Gln His Glu Cys Lys Asn Thr Phe
                 805                 810                 815    
 Gly Ser Tyr Gln Cys Ile Cys Pro Pro Gly Tyr Gln Leu Thr His Asn
             820                 825                 830        
 Gly Lys Thr Cys Gln Asp Ile Asp Glu Cys Leu Glu Gln Asn Val His
         835                 840                 845            
 Cys Gly Pro Asn Arg Met Cys Phe Asn Met Arg Gly Ser Tyr Gln Cys
     850                 855                 860                
 Ile Asp Thr Pro Cys Pro Pro Asn Tyr Gln Arg Asp Pro Val Ser Gly
 865                 870                 875                 880
 Phe Cys Leu Lys Asn Cys Pro Pro Asn Asp Leu Glu Cys Ala Leu Ser
                 885                 890                 895    
 Pro Tyr Ala Leu Glu Tyr Lys Leu Val Ser Leu Pro Phe Gly Ile Ala
             900                 905                 910        
 Thr Asn Gln Asp Leu Ile Arg Leu Val Ala Tyr Thr Gln Asp Gly Val
         915                 920                 925            
 Met His Pro Arg Thr Thr Phe Leu Met Val Asp Glu Glu Gln Thr Val
     930                 935                 940                
 Pro Phe Ala Leu Arg Asp Glu Asn Leu Lys Gly Val Val Tyr Thr Thr
 945                 950                 955                 960
 Arg Pro Leu Arg Glu Ala Glu Thr Tyr Arg Met Arg Val Arg Ala Ser
                 965                 970                 975    
 Ser Tyr Ser Ala Asn Gly Thr Ile Glu Tyr Gln Thr Thr Phe Ile Val
             980                 985                 990        
 Tyr Ile Ala Val Ser Ala Tyr Pro Tyr
         995                1000    



      <210> 914
      <211> 123
      <212> PRT
      <213> Homo sapiens


      <400> 914
 Met Pro Phe Leu Glu Leu His Thr Asn Phe Pro Ala Asn Arg Val Pro
   1               5                  10                  15    
 Ala Gly Leu Glu Lys Arg Leu Cys Ala Val Ala Ala Ser Ile Leu Gly
              20                  25                  30        
 Lys Pro Ala Asp Leu Val Asn Val Thr Val Arg Pro Gly Leu Ala Arg
          35                  40                  45            
 Ala Leu Ser Gly Ser Thr Glu Pro Cys Ala Gln Leu Ser Ile Ser Ser
      50                  55                  60                
 Ile Gly Val Val Gly Thr Ala Glu Asp Asn Arg Ser His Ser Ala His
  65                  70                  75                  80
 Phe Phe Glu Phe Leu Thr Lys Glu Leu Ala Leu Gly Gln Asp Arg Cys
                  85                  90                  95    
 Ala Gly Val Val Gly Pro Glu Tyr Tyr Ser Lys Thr Gln Ser Glu Tyr
             100                 105                 110        
 Ser Ile Pro Ala Asn Ser Leu Lys Pro Asn Thr
         115                 120            



      <210> 915
      <211> 131
      <212> PRT
      <213> Homo sapiens


      <400> 915
 Met Pro Phe Leu Glu Leu His Thr Asn Phe Pro Ala Asn Arg Val Pro
   1               5                  10                  15    
 Ala Gly Leu Glu Lys Arg Leu Cys Ala Val Ala Ala Ser Ile Leu Gly
              20                  25                  30        
 Lys Pro Ala Asp Val Ser Val Gly Arg Ala Ala Leu Gly Glu Gly Lys
          35                  40                  45            
 Leu Leu Val Asn Val Ala Val Arg Pro Gly Leu Ala Met Ala Leu Ser
      50                  55                  60                
 Gly Ser Thr Glu Pro Cys Ala Gln Leu Ser Ile Ser Ser Ile Gly Val
  65                  70                  75                  80
 Val Gly Thr Ala Glu Asp Asn Arg Ser His Ser Ala His Phe Phe Glu
                  85                  90                  95    
 Phe Leu Thr Lys Glu Leu Ala Leu Gly Gln Asp Arg Ile Leu Ile Arg
             100                 105                 110        
 Phe Phe Pro Leu Glu Ser Trp Gln Ile Gly Lys Ile Gly Thr Val Met
         115                 120                 125            
 Thr Phe Leu
     130    



      <210> 916
      <211> 689
      <212> PRT
      <213> Homo sapiens


      <400> 916
 Met Gly Arg Trp Ala Trp Val Pro Ser Pro Trp Pro Pro Pro Gly Leu
   1               5                  10                  15    
 Gly Pro Phe Leu Leu Leu Leu Leu Leu Leu Leu Leu Leu Pro Arg Gly
              20                  25                  30        
 Phe Gln Pro Gln Pro Gly Gly Asn Arg Thr Glu Ser Pro Glu Pro Asn
          35                  40                  45            
 Ala Thr Ala Thr Pro Ala Ile Pro Thr Ile Leu Val Thr Ser Val Thr
      50                  55                  60                
 Ser Glu Thr Pro Ala Thr Ser Ala Pro Glu Ala Glu Gly Pro Gln Ser
  65                  70                  75                  80
 Gly Gly Leu Pro Pro Pro Pro Arg Ala Val Pro Ser Ser Ser Ser Pro
                  85                  90                  95    
 Gln Ala Gln Ala Leu Thr Glu Asp Gly Arg Pro Cys Arg Phe Pro Phe
             100                 105                 110        
 Arg Tyr Gly Gly Arg Met Leu His Ala Cys Thr Ser Glu Gly Ser Ala
         115                 120                 125            
 His Arg Lys Trp Cys Ala Thr Thr His Asn Tyr Asp Arg Asp Arg Ala
     130                 135                 140                
 Trp Gly Tyr Cys Val Glu Ala Thr Pro Pro Pro Gly Gly Pro Ala Ala
 145                 150                 155                 160
 Leu Asp Pro Cys Ala Ser Gly Pro Cys Leu Asn Gly Gly Ser Cys Ser
                 165                 170                 175    
 Asn Thr Gln Asp Pro Gln Ser Tyr His Cys Ser Cys Pro Arg Ala Phe
             180                 185                 190        
 Thr Gly Lys Asp Cys Gly Thr Glu Lys Cys Phe Asp Glu Thr Arg Tyr
         195                 200                 205            
 Glu Tyr Leu Glu Gly Gly Asp Arg Trp Ala Arg Val Arg Gln Gly His
     210                 215                 220                
 Val Glu Gln Cys Glu Cys Phe Gly Gly Arg Thr Trp Cys Glu Gly Thr
 225                 230                 235                 240
 Arg His Thr Ala Cys Leu Ser Ser Pro Cys Leu Asn Gly Gly Thr Cys
                 245                 250                 255    
 His Leu Ile Val Ala Thr Gly Thr Thr Val Cys Ala Cys Pro Pro Gly
             260                 265                 270        
 Phe Ala Gly Arg Leu Cys Asn Ile Glu Pro Asp Glu Arg Cys Phe Leu
         275                 280                 285            
 Gly Asn Gly Thr Gly Tyr Arg Gly Val Ala Ser Thr Ser Ala Ser Gly
     290                 295                 300                
 Leu Ser Cys Leu Ala Trp Asn Ser Asp Leu Leu Tyr Gln Glu Leu His
 305                 310                 315                 320
 Val Asp Ser Val Gly Ala Ala Ala Leu Leu Gly Leu Gly Pro His Ala
                 325                 330                 335    
 Tyr Cys Arg Asn Pro Asp Asn Asp Glu Arg Pro Trp Cys Tyr Val Val
             340                 345                 350        
 Lys Asp Ser Ala Leu Ser Trp Glu Tyr Cys Arg Leu Glu Ala Cys Gly
         355                 360                 365            
 Pro Arg Arg Gly Gln Pro Gly Ala Leu Met Trp Gly Ser Leu Thr Val
     370                 375                 380                
 Leu Gly Leu Ala Val Gly Phe Arg Ala Ala Glu Gly Ala Thr Lys Ala
 385                 390                 395                 400
 Ser Val Cys Pro Ala Pro Leu Ala Leu Thr Glu Pro Arg Asp Arg Ala
                 405                 410                 415    
 Ser Asn Pro Ile Leu Gln Ile Trp Lys Leu Arg Ala Glu Ala Cys Gly
             420                 425                 430        
 Arg Arg His Lys Lys Arg Thr Phe Leu Arg Pro Arg Ile Ile Gly Gly
         435                 440                 445            
 Ser Ser Ser Leu Pro Gly Ser His Pro Trp Leu Ala Ala Ile Tyr Ile
     450                 455                 460                
 Gly Asp Ser Phe Cys Ala Gly Ser Leu Val His Thr Cys Trp Val Val
 465                 470                 475                 480
 Ser Ala Ala His Cys Phe Ser His Arg Asp Ser Val Ser Val Val Leu
                 485                 490                 495    
 Gly Gln His Phe Phe Asn Arg Thr Thr Asp Val Thr Gln Thr Phe Gly
             500                 505                 510        
 Ile Glu Lys Tyr Ile Pro Tyr Thr Leu Tyr Ser Val Phe Asn Pro Ser
         515                 520                 525            
 Asp His Asp Leu Val Leu Ile Arg Leu Lys Lys Lys Gly Asp Arg Cys
     530                 535                 540                
 Ala Thr Arg Ser Gln Phe Val Gln Pro Ile Cys Leu Pro Glu Pro Gly
 545                 550                 555                 560
 Ser Thr Phe Pro Ala Gly His Lys Cys Gln Ile Ala Gly Trp Gly His
                 565                 570                 575    
 Leu Asp Glu Asn Val Ser Gly Tyr Ser Ser Ser Leu Arg Glu Ala Leu
             580                 585                 590        
 Val Pro Leu Val Ala Asp His Lys Cys Ser Ser Pro Glu Val Tyr Gly
         595                 600                 605            
 Ala Asp Ile Ser Pro Asn Met Leu Cys Ala Gly Tyr Phe Asp Cys Lys
     610                 615                 620                
 Ser Asp Ala Cys Gln Gly Asp Ser Gly Gly Pro Leu Ala Cys Glu Lys
 625                 630                 635                 640
 Asn Gly Val Ala Tyr Leu Tyr Gly Ile Ile Ser Trp Gly Asp Gly Cys
                 645                 650                 655    
 Gly Arg Leu His Lys Pro Gly Val Tyr Thr Arg Val Ala Asn Tyr Val
             660                 665                 670        
 Asp Trp Ile Asn Asp Gln Ile Arg Pro Pro Arg Arg Leu Val Ala Pro
         675                 680                 685            
 Ser
    



      <210> 917
      <211> 1670
      <212> PRT
      <213> Homo sapiens


      <400> 917
 Met Pro Arg Leu Leu Pro Glu Pro Leu His Lys Asp Ser Gln Ile Leu
   1               5                  10                  15    
 Thr Ala Phe Arg Val Ser Tyr Phe Cys Cys Val Gln Gly Trp Leu Ser
              20                  25                  30        
 Tyr Ser Lys Ala Gln Asp Asp Cys Asn Arg Gly Ala Cys His Pro Thr
          35                  40                  45            
 Thr Gly Asp Leu Leu Val Gly Arg Asn Thr Gln Leu Met Ala Ser Ser
      50                  55                  60                
 Thr Cys Gly Leu Ser Arg Ala Gln Lys Tyr Cys Ile Leu Ser Tyr Leu
  65                  70                  75                  80
 Glu Gly Glu Gln Lys Cys Phe Ile Cys Asp Ser Arg Phe Pro Tyr Asp
                  85                  90                  95    
 Pro Tyr Asp Gln Pro Asn Ser His Thr Ile Glu Asn Val Ile Val Ser
             100                 105                 110        
 Phe Glu Pro Asp Arg Glu Lys Lys Trp Trp Gln Ser Glu Asn Gly Leu
         115                 120                 125            
 Asp His Val Ser Ile Arg Leu Asp Leu Glu Ala Leu Phe Arg Phe Ser
     130                 135                 140                
 His Leu Ile Leu Thr Phe Lys Thr Phe Arg Pro Ala Ala Met Leu Val
 145                 150                 155                 160
 Glu Arg Ser Thr Asp Tyr Gly His Asn Trp Lys Val Phe Lys Tyr Phe
                 165                 170                 175    
 Ala Lys Asp Cys Ala Thr Ser Phe Pro Asn Ile Thr Ser Gly Gln Ala
             180                 185                 190        
 Gln Gly Val Gly Asp Ile Val Cys Asp Ser Lys Tyr Ser Asp Ile Glu
         195                 200                 205            
 Pro Ser Thr Gly Gly Glu Val Val Leu Lys Val Leu Asp Pro Ser Phe
     210                 215                 220                
 Glu Ile Glu Asn Pro Tyr Ser Pro Tyr Ile Gln Asp Leu Val Thr Leu
 225                 230                 235                 240
 Thr Asn Leu Arg Ile Asn Phe Thr Lys Leu His Thr Leu Gly Asp Ala
                 245                 250                 255    
 Leu Leu Gly Arg Arg Gln Asn Asp Ser Leu Asp Lys Tyr Tyr Tyr Ala
             260                 265                 270        
 Leu Tyr Glu Met Ile Val Arg Gly Ser Cys Phe Cys Asn Gly His Ala
         275                 280                 285            
 Ser Glu Cys Arg Pro Met Gln Lys Met Arg Gly Asp Val Phe Ser Pro
     290                 295                 300                
 Pro Gly Met Val His Gly Gln Cys Val Cys Gln His Asn Thr Asp Gly
 305                 310                 315                 320
 Pro Asn Cys Glu Arg Cys Lys Asp Phe Phe Gln Asp Ala Pro Trp Arg
                 325                 330                 335    
 Pro Ala Ala Asp Leu Gln Asp Asn Ala Cys Arg Ser Cys Ser Cys Asn
             340                 345                 350        
 Ser His Ser Ser Arg Cys His Phe Asp Met Thr Thr Tyr Leu Ala Ser
         355                 360                 365            
 Gly Gly Leu Ser Gly Gly Val Cys Glu Asp Cys Gln His Asn Thr Glu
     370                 375                 380                
 Gly Gln His Cys Asp Arg Cys Arg Pro Leu Phe Tyr Arg Asp Pro Leu
 385                 390                 395                 400
 Lys Thr Ile Ser Asp Pro Tyr Ala Cys Ile Pro Cys Glu Cys Asp Pro
                 405                 410                 415    
 Asp Gly Thr Ile Ser Gly Gly Ile Cys Val Ser His Ser Asp Pro Ala
             420                 425                 430        
 Leu Gly Ser Val Ala Gly Gln Cys Leu Cys Lys Glu Asn Val Glu Gly
         435                 440                 445            
 Ala Lys Cys Asp Gln Cys Lys Pro Asn His Tyr Gly Leu Ser Ala Thr
     450                 455                 460                
 Asp Pro Leu Gly Cys Gln Pro Cys Asp Cys Asn Pro Leu Gly Ser Leu
 465                 470                 475                 480
 Pro Phe Leu Thr Cys Asp Val Asp Thr Gly Gln Cys Leu Cys Leu Ser
                 485                 490                 495    
 Tyr Val Thr Gly Ala His Cys Glu Glu Cys Thr Val Gly Tyr Trp Gly
             500                 505                 510        
 Leu Gly Asn His Leu His Gly Cys Ser Pro Cys Asp Cys Asp Ile Gly
         515                 520                 525            
 Gly Ala Tyr Ser Asn Val Cys Ser Pro Lys Asn Gly Gln Cys Glu Cys
     530                 535                 540                
 Arg Pro His Val Thr Gly Arg Ser Cys Ser Glu Pro Ala Pro Gly Tyr
 545                 550                 555                 560
 Phe Phe Ala Pro Leu Asn Phe Tyr Leu Tyr Glu Ala Glu Glu Ala Thr
                 565                 570                 575    
 Thr Leu Gln Gly Leu Ala Pro Leu Gly Ser Glu Thr Phe Gly Gln Ser
             580                 585                 590        
 Pro Ala Val His Val Val Leu Gly Glu Pro Val Pro Gly Asn Pro Val
         595                 600                 605            
 Thr Trp Thr Gly Pro Gly Phe Ala Arg Val Leu Pro Gly Ala Gly Leu
     610                 615                 620                
 Arg Phe Ala Val Asn Asn Ile Pro Phe Pro Val Asp Phe Thr Ile Ala
 625                 630                 635                 640
 Ile His Tyr Glu Thr Gln Ser Ala Ala Asp Trp Thr Val Gln Ile Val
                 645                 650                 655    
 Val Asn Pro Pro Gly Gly Ser Glu His Cys Ile Pro Lys Thr Leu Gln
             660                 665                 670        
 Ser Lys Pro Gln Ser Phe Ala Leu Pro Ala Ala Thr Arg Ile Met Leu
         675                 680                 685            
 Leu Pro Thr Pro Ile Cys Leu Glu Pro Asp Val Gln Tyr Ser Ile Asp
     690                 695                 700                
 Val Tyr Phe Ser Gln Pro Leu Gln Gly Glu Ser His Ala His Ser His
 705                 710                 715                 720
 Val Leu Val Asp Ser Leu Gly Leu Ile Pro Gln Ile Asn Ser Leu Glu
                 725                 730                 735    
 Asn Phe Cys Ser Lys Gln Asp Leu Asp Glu Tyr Gln Leu His Asn Cys
             740                 745                 750        
 Val Glu Ile Ala Ser Ala Met Gly Pro Gln Val Leu Pro Gly Ala Cys
         755                 760                 765            
 Glu Arg Leu Ile Ile Ser Met Ser Ala Lys Leu His Asp Gly Ala Val
     770                 775                 780                
 Ala Cys Lys Cys His Pro Gln Gly Ser Val Gly Ser Ser Cys Ser Arg
 785                 790                 795                 800
 Leu Gly Gly Gln Cys Gln Cys Lys Pro Leu Val Val Gly Arg Cys Cys
                 805                 810                 815    
 Asp Arg Cys Ser Thr Gly Ser Tyr Asp Leu Gly His His Gly Cys His
             820                 825                 830        
 Pro Cys His Cys His Pro Gln Gly Ser Lys Asp Thr Val Cys Asp Gln
         835                 840                 845            
 Val Thr Gly Gln Cys Pro Cys His Gly Glu Val Ser Gly Arg Arg Cys
     850                 855                 860                
 Asp Arg Cys Leu Ala Gly Tyr Phe Gly Phe Pro Ser Cys His Pro Cys
 865                 870                 875                 880
 Pro Cys Asn Arg Phe Ala Glu Leu Cys Asp Pro Glu Thr Gly Ser Cys
                 885                 890                 895    
 Phe Asn Cys Gly Gly Phe Thr Thr Gly Arg Asn Cys Glu Arg Cys Ile
             900                 905                 910        
 Asp Gly Tyr Tyr Gly Asn Pro Ser Ser Gly Gln Pro Cys Arg Pro Cys
         915                 920                 925            
 Leu Cys Pro Asp Asp Pro Ser Ser Asn Gln Tyr Phe Ala His Ser Cys
     930                 935                 940                
 Tyr Gln Asn Leu Trp Ser Ser Asp Val Ile Cys Asn Cys Leu Gln Gly
 945                 950                 955                 960
 Tyr Thr Gly Thr Gln Cys Gly Glu Cys Ser Thr Gly Phe Tyr Gly Asn
                 965                 970                 975    
 Pro Arg Ile Ser Gly Ala Pro Cys Gln Pro Cys Ala Cys Asn Asn Asn
             980                 985                 990        
 Ile Asp Val Thr Asp Pro Glu Ser Cys Ser Arg Val Thr Gly Glu Cys
         995                1000                1005            
 Leu Arg Cys Leu His Asn Thr Gln Gly Ala Asn Cys Gln Leu Cys Lys
    1010                1015                1020                
 Pro Gly His Tyr Gly Ser Ala Leu Asn Gln Thr Cys Arg Arg Cys Ser
1025                1030                1035                1040
 Cys His Ala Ser Gly Val Ser Pro Met Glu Cys Pro Pro Gly Gly Gly
                1045                1050                1055    
 Ala Cys Leu Cys Asp Pro Val Thr Gly Ala Cys Pro Cys Leu Pro Asn
            1060                1065                1070        
 Val Thr Gly Leu Ala Cys Asp Arg Cys Ala Asp Gly Tyr Trp Asn Leu
        1075                1080                1085            
 Val Pro Gly Arg Gly Ser Cys Asp Cys Asn Arg Ala Gly Thr Gln Lys
    1090                1095                1100                
 Pro Ile Cys Asp Pro Asp Thr Gly Met Cys Arg Cys Arg Glu Gly Val
1105                1110                1115                1120
 Ser Gly Gln Arg Cys Asp Arg Cys Ala Arg Gly His Ser Gln Glu Phe
                1125                1130                1135    
 Pro Thr Cys Leu Gln Cys His Leu Cys Phe Asp Gln Trp Asp His Thr
            1140                1145                1150        
 Ile Ser Ser Leu Ser Lys Ala Val Gln Gly Leu Met Arg Leu Ala Ala
        1155                1160                1165            
 Asn Met Glu Asp Lys Arg Glu Thr Leu Pro Val Cys Glu Ala Asp Phe
    1170                1175                1180                
 Lys Asp Leu Arg Gly Asn Val Ser Glu Ile Glu Arg Ile Leu Lys His
1185                1190                1195                1200
 Pro Val Phe Pro Ser Gly Lys Phe Leu Lys Val Lys Asp Tyr His Asp
                1205                1210                1215    
 Ser Val Arg Arg Gln Ile Met Gln Leu Asn Glu Gln Leu Lys Ala Val
            1220                1225                1230        
 Tyr Glu Phe Gln Asp Leu Lys Asp Thr Ile Glu Arg Ala Lys Asn Glu
        1235                1240                1245            
 Ala Asp Leu Leu Leu Glu Asp Leu Gln Glu Glu Ile Asp Leu Gln Ser
    1250                1255                1260                
 Ser Val Leu Asn Ala Ser Ile Ala Asp Ser Ser Glu Asn Ile Lys Lys
1265                1270                1275                1280
 Tyr Tyr His Ile Ser Ser Ser Ala Glu Lys Lys Ile Asn Glu Thr Ser
                1285                1290                1295    
 Ser Thr Ile Asn Thr Ser Ala Asn Thr Arg Asn Asp Leu Leu Thr Ile
            1300                1305                1310        
 Leu Asp Thr Leu Thr Ser Lys Gly Asn Leu Ser Leu Glu Arg Leu Lys
        1315                1320                1325            
 Gln Ile Lys Ile Pro Asp Ile Gln Ile Leu Asn Glu Lys Val Cys Gly
    1330                1335                1340                
 Asp Pro Gly Asn Val Pro Cys Val Pro Leu Pro Cys Gly Gly Ala Leu
1345                1350                1355                1360
 Cys Thr Gly Arg Lys Gly His Arg Lys Cys Arg Gly Pro Gly Cys His
                1365                1370                1375    
 Gly Ser Leu Thr Leu Ser Thr Asn Ala Leu Gln Lys Ala Gln Glu Ala
            1380                1385                1390        
 Lys Ser Ile Ile Arg Asn Leu Asp Lys Gln Val Arg Gly Leu Lys Asn
        1395                1400                1405            
 Gln Ile Glu Ser Ile Ser Glu Gln Ala Glu Val Ser Lys Asn Asn Ala
    1410                1415                1420                
 Leu Gln Leu Arg Glu Lys Leu Gly Asn Ile Arg Asn Gln Ser Asp Ser
1425                1430                1435                1440
 Glu Glu Glu Asn Ile Asn Leu Phe Ile Lys Lys Val Lys Asn Phe Leu
                1445                1450                1455    
 Leu Glu Glu Asn Val Pro Pro Glu Asp Ile Glu Lys Val Ala Asn Gly
            1460                1465                1470        
 Val Leu Asp Ile His Leu Pro Ile Pro Ser Gln Asn Leu Thr Asp Glu
        1475                1480                1485            
 Leu Val Lys Ile Gln Lys His Met Gln Leu Cys Glu Asp Tyr Arg Thr
    1490                1495                1500                
 Asp Glu Asn Arg Leu Asn Glu Glu Ala Asp Gly Ala Gln Lys Leu Leu
1505                1510                1515                1520
 Val Lys Ala Lys Ala Ala Glu Lys Ala Ala Asn Ile Leu Leu Asn Leu
                1525                1530                1535    
 Asp Lys Thr Leu Asn Gln Leu Gln Gln Ala Gln Ile Thr Gln Gly Arg
            1540                1545                1550        
 Ala Asn Ser Thr Ile Thr Gln Leu Thr Ala Asn Ile Thr Lys Ile Lys
        1555                1560                1565            
 Lys Asn Val Leu Gln Glu Phe Val Glu Leu Lys Lys Gln Tyr Ala Ile
    1570                1575                1580                
 Leu Gln Arg Lys Thr Ser Thr Thr Gly Leu Thr Lys Glu Thr Leu Gly
1585                1590                1595                1600
 Lys Val Lys Gln Leu Lys Asp Ala Ala Glu Lys Leu Ala Gly Asp Thr
                1605                1610                1615    
 Glu Ala Lys Ile Arg Arg Ile Thr Asp Leu Glu Arg Lys Ile Gln Asp
            1620                1625                1630        
 Leu Asn Leu Ser Arg Gln Ala Lys Ala Asp Gln Leu Arg Ile Leu Glu
        1635                1640                1645            
 Asp Gln Val Val Ala Ile Lys Asn Glu Ile Val Glu Gln Glu Lys Lys
    1650                1655                1660                
 Tyr Ala Arg Cys Tyr Ser
1665                1670



      <210> 918
      <211> 897
      <212> PRT
      <213> Homo sapiens


      <400> 918
 Met Gly Ser Gly Arg Val Pro Gly Leu Cys Leu Leu Val Leu Leu Val
   1               5                  10                  15    
 His Ala Arg Ala Ala Gln Tyr Ser Lys Ala Ala Gln Asp Val Asp Glu
              20                  25                  30        
 Cys Val Glu Gly Thr Asp Asn Cys His Ile Asp Ala Ile Cys Gln Asn
          35                  40                  45            
 Thr Pro Arg Ser Tyr Lys Cys Ile Cys Lys Ser Gly Tyr Thr Gly Asp
      50                  55                  60                
 Gly Lys His Cys Lys Asp Val Asp Glu Cys Glu Arg Glu Asp Asn Ala
  65                  70                  75                  80
 Gly Cys Val His Asp Cys Val Asn Ile Pro Gly Asn Tyr Arg Cys Thr
                  85                  90                  95    
 Cys Tyr Asp Gly Phe His Leu Ala His Asp Gly His Asn Cys Leu Asp
             100                 105                 110        
 Val Asp Glu Cys Ala Glu Gly Asn Gly Gly Cys Gln Gln Ser Cys Val
         115                 120                 125            
 Asn Met Met Gly Ser Tyr Glu Cys His Cys Arg Glu Gly Phe Phe Leu
     130                 135                 140                
 Ser Asp Asn Gln His Thr Cys Ile Gln Arg Pro Glu Glu Gly Met Asn
 145                 150                 155                 160
 Cys Met Asn Lys Asn His Gly Cys Ala His Ile Cys Arg Glu Thr Pro
                 165                 170                 175    
 Lys Gly Gly Ile Ala Cys Glu Cys Arg Pro Gly Phe Glu Leu Thr Lys
             180                 185                 190        
 Asn Gln Arg Asp Cys Lys Cys Glu Ile Ile Gly Met Ala Val Thr Cys
         195                 200                 205            
 Asn Tyr Gly Asn Gly Gly Cys Gln His Thr Cys Asp Asp Thr Glu Gln
     210                 215                 220                
 Gly Pro Arg Cys Gly Cys His Ile Lys Phe Val Leu His Thr Asp Gly
 225                 230                 235                 240
 Lys Thr Cys Ile Glu Thr Cys Ala Val Asn Asn Gly Gly Cys Asp Ser
                 245                 250                 255    
 Lys Cys His Asp Ala Ala Thr Gly Val His Cys Thr Cys Pro Val Gly
             260                 265                 270        
 Phe Met Leu Gln Pro Asp Arg Lys Thr Cys Lys Asp Ile Asp Glu Cys
         275                 280                 285            
 Arg Leu Asn Asn Gly Gly Cys Asp His Ile Cys Arg Asn Thr Val Gly
     290                 295                 300                
 Ser Phe Glu Cys Ser Cys Lys Lys Gly Tyr Lys Leu Leu Ile Asn Glu
 305                 310                 315                 320
 Arg Asn Cys Gln Asp Ile Asp Glu Cys Ser Phe Asp Arg Thr Cys Asp
                 325                 330                 335    
 His Ile Cys Val Asn Thr Pro Gly Ser Phe Gln Cys Leu Cys His Arg
             340                 345                 350        
 Gly Tyr Leu Leu Tyr Gly Ile Thr His Cys Gly Asp Val Asp Glu Cys
         355                 360                 365            
 Ser Ile Asn Arg Gly Gly Cys Arg Phe Gly Cys Ile Asn Thr Pro Gly
     370                 375                 380                
 Ser Tyr Gln Cys Thr Cys Pro Ala Gly Gln Gly Arg Leu His Trp Asn
 385                 390                 395                 400
 Gly Lys Asp Cys Thr Glu Pro Leu Lys Cys Gln Gly Ser Pro Gly Ala
                 405                 410                 415    
 Ser Lys Ala Met Leu Ser Cys Asn Arg Ser Gly Lys Lys Asp Thr Cys
             420                 425                 430        
 Ala Leu Thr Cys Pro Ser Arg Ala Arg Phe Leu Pro Glu Ser Glu Asn
         435                 440                 445            
 Gly Phe Thr Val Ser Cys Gly Thr Pro Ser Pro Arg Ala Ala Pro Ala
     450                 455                 460                
 Arg Ala Gly His Asn Gly Asn Ser Thr Asn Ser Asn His Cys His Glu
 465                 470                 475                 480
 Ala Ala Val Leu Ser Ile Lys Gln Arg Ala Ser Phe Lys Ile Lys Asp
                 485                 490                 495    
 Ala Lys Cys Arg Leu His Leu Arg Asn Lys Gly Lys Thr Glu Glu Ala
             500                 505                 510        
 Gly Arg Ile Thr Gly Pro Gly Gly Ala Pro Cys Ser Glu Cys Gln Val
         515                 520                 525            
 Thr Phe Ile His Leu Lys Cys Asp Ser Ser Arg Lys Gly Lys Gly Arg
     530                 535                 540                
 Arg Ala Arg Thr Pro Pro Gly Lys Glu Val Thr Arg Leu Thr Leu Glu
 545                 550                 555                 560
 Leu Glu Ala Glu Gln Leu Phe Leu Leu Pro Asp Thr His Gly His Pro
                 565                 570                 575    
 Pro Pro Ala Ser Cys Gly Leu Pro Cys Leu Arg Gln Arg Met Glu Arg
             580                 585                 590        
 Arg Leu Lys Gly Ser Leu Lys Met Leu Arg Lys Ser Ile Asn Gln Asp
         595                 600                 605            
 Arg Phe Leu Leu Arg Leu Ala Gly Leu Asp Tyr Glu Leu Ala His Lys
     610                 615                 620                
 Pro Gly Leu Val Ala Gly Glu Arg Ala Glu Pro Met Glu Ser Cys Arg
 625                 630                 635                 640
 Pro Gly Gln His Arg Ala Gly Thr Lys Cys Val Gln Cys Ser Pro Gly
                 645                 650                 655    
 His Tyr Tyr Asn Thr Ser Ile His Arg Cys Ile Arg Cys Ala Met Gly
             660                 665                 670        
 Ser Tyr Gln Pro Asp Phe Arg Gln Asn Phe Cys Ser Arg Cys Pro Gly
         675                 680                 685            
 Asn Thr Ser Thr Asp Phe Asp Gly Ser Thr Ser Val Ala Gln Cys Lys
     690                 695                 700                
 Asn Arg Gln Cys Gly Gly Glu Leu Gly Glu Phe Thr Gly Tyr Ile Glu
 705                 710                 715                 720
 Ser Pro Asn Tyr Pro Gly Asn Tyr Pro Ala Gly Val Glu Cys Ile Trp
                 725                 730                 735    
 Asn Ile Asn Pro Pro Pro Lys Arg Lys Ile Leu Ile Val Val Pro Glu
             740                 745                 750        
 Ile Phe Leu Pro Ser Glu Asp Glu Cys Gly Asp Val Leu Val Met Arg
         755                 760                 765            
 Lys Asn Ser Ser Pro Ser Ser Ile Thr Thr Tyr Glu Thr Cys Gln Thr
     770                 775                 780                
 Tyr Glu Arg Pro Ile Ala Phe Thr Ala Arg Ser Arg Lys Leu Trp Ile
 785                 790                 795                 800
 Asn Phe Lys Thr Ser Glu Ala Asn Ser Ala Arg Gly Phe Gln Ile Pro
                 805                 810                 815    
 Tyr Val Thr Tyr Asp Glu Asp Tyr Glu Gln Leu Val Glu Asp Ile Val
             820                 825                 830        
 Arg Asp Gly Arg Leu Tyr Ala Ser Glu Asn His Gln Glu Ile Leu Lys
         835                 840                 845            
 Asp Lys Lys Leu Ile Lys Ala Phe Phe Glu Val Leu Ala His Pro Gln
     850                 855                 860                
 Asn Tyr Phe Lys Tyr Thr Glu Lys His Lys Glu Met Leu Pro Lys Ser
 865                 870                 875                 880
 Phe Ile Lys Leu Leu Arg Ser Lys Val Ser Ser Phe Leu Arg Pro Tyr
                 885                 890                 895    
 Lys
    



      <210> 919
      <211> 220
      <212> PRT
      <213> Homo sapiens


      <400> 919
 Met Ser Pro Ser Ser Phe Leu Arg Gln Val Cys Leu Gly Ala Cys Glu
   1               5                  10                  15    
 His Ser Ser Ala Arg Phe Ser Thr Arg Leu Gln Pro Ala Pro Pro Gly
              20                  25                  30        
 Gln His Val Ser Pro Pro Ala Arg Ala Arg Ala Glu Thr Met Gln Arg
          35                  40                  45            
 Arg Leu Val Gln Gln Trp Ser Val Ala Val Phe Leu Leu Ser Tyr Ala
      50                  55                  60                
 Val Pro Ser Cys Gly Arg Ser Val Glu Gly Leu Ser Arg Arg Leu Lys
  65                  70                  75                  80
 Arg Ala Val Ser Glu His Gln Leu Leu His Asp Lys Gly Lys Ser Ile
                  85                  90                  95    
 Gln Asp Leu Arg Arg Arg Phe Phe Leu His His Leu Ile Ala Glu Ile
             100                 105                 110        
 His Thr Ala Glu Ile Arg Ala Thr Ser Glu Val Ser Pro Asn Ser Lys
         115                 120                 125            
 Pro Ser Pro Asn Thr Lys Asn His Pro Val Arg Phe Gly Ser Asp Asp
     130                 135                 140                
 Glu Gly Arg Tyr Leu Thr Gln Glu Thr Asn Lys Val Glu Thr Tyr Lys
 145                 150                 155                 160
 Glu Gln Pro Leu Lys Thr Pro Gly Lys Lys Lys Lys Gly Lys Pro Gly
                 165                 170                 175    
 Lys Arg Lys Glu Gln Glu Lys Lys Lys Arg Arg Thr Arg Ser Ala Trp
             180                 185                 190        
 Leu Asp Ser Gly Val Thr Gly Ser Gly Leu Glu Gly Asp His Leu Ser
         195                 200                 205            
 Asp Thr Ser Thr Thr Ser Leu Glu Leu Asp Ser Arg
     210                 215                 220



      <210> 920
      <211> 485
      <212> PRT
      <213> Homo sapiens


      <400> 920
 Met Cys Arg Met Ala Gly Gln Cys Ala His Gly Cys Leu Asn Thr Gln
   1               5                  10                  15    
 Gly Ser Phe Lys Cys Val Cys His Ala Gly Tyr Glu Leu Gly Ala Asp
              20                  25                  30        
 Gly Arg Gln Cys Tyr Arg Ile Glu Met Glu Ile Val Asn Ser Cys Glu
          35                  40                  45            
 Ala Asn Asn Gly Gly Cys Ser His Gly Cys Ser His Thr Ser Ala Gly
      50                  55                  60                
 Pro Leu Cys Thr Cys Pro Arg Gly Tyr Glu Leu Asp Thr Asp Gln Arg
  65                  70                  75                  80
 Thr Cys Ile Asp Val Asp Asp Cys Ala Asp Ser Pro Cys Cys Gln Gln
                  85                  90                  95    
 Val Cys Thr Asn Asn Pro Gly Gly Tyr Glu Cys Gly Cys Tyr Ala Gly
             100                 105                 110        
 Tyr Arg Leu Ser Ala Asp Gly Cys Gly Cys Glu Asp Val Asp Glu Cys
         115                 120                 125            
 Ala Ser Ser Arg Gly Gly Cys Glu His His Cys Thr Asn Leu Ala Gly
     130                 135                 140                
 Ser Phe Gln Cys Ser Cys Glu Ala Gly Tyr Arg Leu His Glu Asp Arg
 145                 150                 155                 160
 Arg Gly Cys Ser Pro Leu Glu Glu Pro Met Val Asp Leu Asp Gly Glu
                 165                 170                 175    
 Leu Pro Phe Val Arg Pro Leu Pro His Ile Ala Val Leu Gln Asp Glu
             180                 185                 190        
 Leu Pro Gln Leu Phe Gln Asp Asp Asp Val Gly Ala Asp Glu Glu Glu
         195                 200                 205            
 Ala Glu Leu Arg Gly Glu His Thr Leu Thr Glu Lys Phe Val Cys Leu
     210                 215                 220                
 Asp Asp Ser Phe Gly His Asp Cys Ser Leu Thr Cys Asp Asp Cys Arg
 225                 230                 235                 240
 Asn Gly Gly Thr Cys Leu Leu Gly Leu Asp Gly Cys Asp Cys Pro Glu
                 245                 250                 255    
 Gly Trp Thr Gly Leu Ile Cys Asn Glu Thr Cys Pro Pro Asp Thr Phe
             260                 265                 270        
 Gly Lys Asn Cys Ser Phe Ser Cys Ser Cys Gln Asn Gly Gly Thr Cys
         275                 280                 285            
 Asp Ser Val Thr Gly Ala Cys Arg Cys Pro Pro Gly Val Ser Gly Thr
     290                 295                 300                
 Asn Cys Glu Asp Gly Cys Pro Lys Gly Tyr Tyr Gly Lys His Cys Arg
 305                 310                 315                 320
 Lys Lys Cys Asn Cys Ala Asn Arg Gly Arg Cys His Arg Leu Tyr Gly
                 325                 330                 335    
 Ala Cys Leu Cys Asp Pro Gly Leu Tyr Gly Arg Phe Cys His Leu Thr
             340                 345                 350        
 Cys Pro Pro Trp Ala Phe Gly Pro Gly Cys Ser Glu Glu Cys Gln Cys
         355                 360                 365            
 Val Gln Pro His Thr Leu Ser Cys Asp Lys Arg Asp Gly Ser Cys Ser
     370                 375                 380                
 Cys Lys Ala Gly Phe Arg Gly Glu Arg Cys Gln Ala Glu Cys Glu Leu
 385                 390                 395                 400
 Gly Tyr Phe Gly Pro Gly Cys Trp Gln Ala Cys Thr Cys Pro Val Gly
                 405                 410                 415    
 Val Ala Cys Asp Ser Val Ser Gly Glu Cys Gly Lys Arg Cys Pro Ala
             420                 425                 430        
 Gly Phe Gln Gly Glu Asp Cys Gly Gln Ala Gln Val Val Pro Cys Tyr
         435                 440                 445            
 Arg Cys Cys Leu Ala Thr Gly Val Ala Leu Thr Ala Cys His Met Ala
     450                 455                 460                
 Val Val Arg Leu Leu Val Ser Val Trp Ser Thr Gln Gly Ser Ser Cys
 465                 470                 475                 480
 Cys Leu Pro Arg Ala
                 485



      <210> 921
      <211> 65
      <212> PRT
      <213> Homo sapiens


      <400> 921
 Met Lys Ile Ser Val Ala Ala Ile Pro Phe Phe Leu Leu Ile Thr Ile
   1               5                  10                  15    
 Ala Leu Gly Thr Lys Thr Glu Ser Ser Ser Arg Gly Pro Tyr His Pro
              20                  25                  30        
 Ser Glu Cys Cys Phe Thr Tyr Thr Thr Tyr Lys Ile Pro Arg Gln Arg
          35                  40                  45            
 Ile Met Asp Tyr Tyr Glu Thr Asn Ser Gln Cys Ser Lys Pro Gly Ile
      50                  55                  60                
 Val
  65



      <210> 922
      <211> 446
      <212> PRT
      <213> Homo sapiens


      <400> 922
 Met Asn Phe Thr Gly Asp Gln Val Leu Arg Val Leu Ala Lys Asp Glu
   1               5                  10                  15    
 Lys Gln Leu Ser Leu Leu Gly Asp Leu Glu Gly Leu Lys Pro Gln Lys
              20                  25                  30        
 Val Asp Phe Trp Arg Gly Pro Ala Arg Pro Ser Leu Pro Val Asp Met
          35                  40                  45            
 Arg Val Pro Phe Ser Glu Leu Lys Asp Ile Lys Ala Tyr Leu Glu Ser
      50                  55                  60                
 His Gly Leu Ala Tyr Ser Ile Met Ile Lys Asp Ile Gln Phe Thr Leu
  65                  70                  75                  80
 Met Val Ala His Ser Pro Val Leu Leu Leu Ser Leu Cys Thr Ala Ser
                  85                  90                  95    
 Gly Gly Arg Ala Gln Lys Arg His Ser Gln Pro Ser Ser Pro Leu Pro
             100                 105                 110        
 Phe Gln Tyr Val Phe Pro Ile Thr Gln Val Leu Leu Asp Glu Glu Arg
         115                 120                 125            
 Gln Ala Met Ala Lys Ser Arg Arg Leu Glu Arg Ser Thr Asn Ser Phe
     130                 135                 140                
 Ser Tyr Ser Ser Tyr His Thr Leu Glu Glu Ile Tyr Ser Trp Ile Asp
 145                 150                 155                 160
 Asn Phe Val Met Glu His Ser Asp Ile Val Ser Lys Ile Gln Ile Gly
                 165                 170                 175    
 Asn Ser Phe Glu Asn Gln Ser Ile Leu Val Leu Lys Phe Ser Thr Gly
             180                 185                 190        
 Gly Ser Arg His Pro Ala Ile Trp Ile Asp Thr Gly Ile His Ser Arg
         195                 200                 205            
 Glu Trp Ile Thr His Ala Thr Gly Ile Trp Thr Ala Asn Lys Ile Val
     210                 215                 220                
 Ser Asp Tyr Gly Lys Asp Arg Val Leu Thr Asp Ile Leu Asn Ala Met
 225                 230                 235                 240
 Asp Ile Phe Ile Glu Leu Val Thr Asn Pro Asp Gly Phe Ala Phe Thr
                 245                 250                 255    
 His Ser Met Asn Cys Leu Trp Arg Lys Asn Lys Ser Ile Arg Pro Gly
             260                 265                 270        
 Ile Phe Cys Ile Gly Val Asp Leu Asn Arg Asn Trp Lys Ser Gly Phe
         275                 280                 285            
 Gly Gly Asn Gly Ser Asn Ser Asn Pro Cys Ser Glu Thr Tyr His Gly
     290                 295                 300                
 Pro Ser Pro Gln Ser Glu Pro Glu Val Ala Ala Ile Val Asn Phe Ile
 305                 310                 315                 320
 Thr Ala His Gly Asn Phe Lys Ala Leu Ile Ser Ile His Ser Tyr Ser
                 325                 330                 335    
 Gln Met Leu Met Tyr Pro Tyr Gly Arg Leu Leu Glu Pro Val Ser Asn
             340                 345                 350        
 Gln Arg Glu Leu Tyr Asp Leu Ala Lys Asp Ala Val Glu Ala Leu Tyr
         355                 360                 365            
 Lys Val His Gly Ile Glu Tyr Ile Phe Gly Ser Ile Ser Thr Thr Leu
     370                 375                 380                
 Tyr Val Ala Ser Gly Ile Thr Val Asp Trp Ala Tyr Asp Ser Gly Ile
 385                 390                 395                 400
 Lys Tyr Ala Phe Ser Phe Glu Leu Arg Asp Thr Gly Gln Tyr Gly Phe
                 405                 410                 415    
 Leu Leu Pro Ala Thr Gln Ile Ile Pro Thr Ala Gln Glu Thr Trp Met
             420                 425                 430        
 Ala Leu Arg Thr Ile Met Glu His Thr Leu Asn His Pro Tyr
         435                 440                 445    



      <210> 923
      <211> 275
      <212> PRT
      <213> Homo sapiens


      <400> 923
 Met Val Gly Ala Asn Ala Lys Arg Thr Gly Asp Leu Trp Ser Trp Glu
   1               5                  10                  15    
 Gly Ala Val Leu Thr Leu Ser Ala His Arg Gln Ala Leu Leu Ala Leu
              20                  25                  30        
 Pro Leu Leu Leu Leu Leu Ser Thr Pro Pro Cys Ala Pro Gln Val Ser
          35                  40                  45            
 Gly Ile Arg Gly Asp Ala Leu Glu Arg Phe Cys Leu Gln Gln Pro Leu
      50                  55                  60                
 Asp Cys Asp Asp Ile Tyr Ala Gln Gly Tyr Gln Ser Asp Gly Val Tyr
  65                  70                  75                  80
 Leu Ile Tyr Pro Ser Gly Pro Ser Val Pro Val Pro Val Phe Cys Asp
                  85                  90                  95    
 Met Thr Thr Glu Gly Gly Lys Trp Thr Val Phe Gln Lys Arg Phe Asn
             100                 105                 110        
 Gly Ser Val Ser Phe Phe Arg Gly Trp Asn Asp Tyr Lys Leu Gly Phe
         115                 120                 125            
 Gly Arg Ala Asp Gly Glu Tyr Trp Leu Gly Leu Gln Asn Met His Leu
     130                 135                 140                
 Leu Thr Leu Lys Gln Lys Tyr Glu Leu Arg Val Asp Leu Glu Asp Phe
 145                 150                 155                 160
 Glu Asn Asn Thr Ala Tyr Ala Lys Tyr Ala Asp Phe Ser Ile Ser Pro
                 165                 170                 175    
 Asn Ala Val Ser Ala Glu Glu Asp Gly Tyr Thr Leu Phe Val Ala Gly
             180                 185                 190        
 Phe Glu Asp Gly Gly Ala Gly Asp Ser Leu Ser Tyr His Ser Gly Gln
         195                 200                 205            
 Lys Phe Ser Thr Phe Asp Arg Asp Gln Asp Leu Phe Val Gln Asn Cys
     210                 215                 220                
 Ala Ala Leu Ser Ser Gly Ala Phe Trp Phe Arg Ser Cys His Phe Ala
 225                 230                 235                 240
 Asn Leu Asn Gly Phe Tyr Leu Gly Trp Leu Pro Pro Leu Leu Cys Gln
                 245                 250                 255    
 Trp Ala Ser Thr Gly Pro Ser Gly Arg Ala Ser Thr Thr Pro Ser Asn
             260                 265                 270        
 Ala Leu Arg
         275



      <210> 924
      <211> 352
      <212> PRT
      <213> Homo sapiens


      <400> 924
 Met Arg Pro Trp Gly Ser Pro Tyr Ser Ser Gly Gln Pro Thr Ser Ala
   1               5                  10                  15    
 Ala Thr Gly Ala Gly His Ala Pro Gly Pro Trp Ser Cys Leu Glu Val
              20                  25                  30        
 Gln Cys Trp Gly Ser Arg Ala Met Ser Asp Leu Leu Leu Leu Gly Leu
          35                  40                  45            
 Ile Gly Gly Leu Thr Leu Leu Leu Leu Leu Thr Leu Leu Ala Phe Ala
      50                  55                  60                
 Gly Tyr Ser Gly Leu Leu Ala Gly Val Glu Val Ser Ala Gly Ser Pro
  65                  70                  75                  80
 Pro Ile Arg Asn Val Thr Val Ala Tyr Lys Phe His Met Gly Leu Tyr
                  85                  90                  95    
 Gly Glu Thr Gly Arg Leu Phe Thr Glu Ser Cys Ser Ile Ser Pro Lys
             100                 105                 110        
 Leu Arg Ser Ile Ala Val Tyr Tyr Asp Asn Pro His Met Val Pro Pro
         115                 120                 125            
 Asp Lys Cys Arg Cys Ala Val Gly Ser Ile Leu Ser Glu Gly Glu Glu
     130                 135                 140                
 Ser Pro Ser Pro Glu Leu Ile Asp Leu Tyr Gln Lys Phe Gly Phe Lys
 145                 150                 155                 160
 Val Phe Ser Phe Pro Ala Pro Ser His Val Val Thr Ala Thr Phe Pro
                 165                 170                 175    
 Tyr Thr Thr Ile Leu Ser Ile Trp Leu Ala Thr Arg Arg Val His Pro
             180                 185                 190        
 Ala Leu Asp Thr Tyr Ile Lys Glu Arg Lys Leu Cys Ala Tyr Pro Arg
         195                 200                 205            
 Leu Glu Ile Tyr Gln Glu Asp Gln Ile His Phe Met Cys Pro Leu Ala
     210                 215                 220                
 Arg Gln Gly Asp Phe Tyr Val Pro Glu Met Lys Glu Thr Glu Trp Lys
 225                 230                 235                 240
 Trp Arg Gly Leu Val Glu Ala Ile Asp Thr Gln Val Asp Gly Thr Gly
                 245                 250                 255    
 Ala Asp Thr Met Ser Asp Thr Ser Ser Val Ser Leu Glu Val Ser Pro
             260                 265                 270        
 Gly Ser Arg Glu Thr Ser Ala Ala Thr Leu Ser Pro Gly Ala Ser Ser
         275                 280                 285            
 Arg Gly Trp Asp Asp Gly Asp Thr Arg Ser Glu His Ser Tyr Ser Glu
     290                 295                 300                
 Ser Gly Ala Ser Gly Ser Ser Phe Glu Glu Leu Asp Leu Glu Gly Glu
 305                 310                 315                 320
 Gly Pro Leu Gly Glu Ser Arg Leu Asp Pro Gly Thr Glu Pro Leu Gly
                 325                 330                 335    
 Thr Thr Lys Trp Leu Trp Glu Pro Thr Ala Pro Glu Lys Gly Lys Glu
             340                 345                 350        





      <210> 925
      <211> 100
      <212> PRT
      <213> Homo sapiens


      <400> 925
 Met Lys Leu Leu Ala Gly Thr Glu Leu Leu Leu Thr Ile Trp Ser Leu
   1               5                  10                  15    
 Glu Gly Ala Leu Asp Arg Lys Gln Ala Lys Glu Pro Cys Val Glu Ser
              20                  25                  30        
 Leu Gly Ser Gln Tyr Phe Gln Thr Val Thr Asp Tyr Gly Lys Asp Leu
          35                  40                  45            
 Met Asp Lys Val Lys Ser Pro Glu Leu Gln Ala Glu Ala Lys Ser Tyr
      50                  55                  60                
 Phe Glu Lys Pro Lys Glu Gln Leu Thr Pro Leu Ile Lys Lys Ala Gly
  65                  70                  75                  80
 Thr Glu Leu Val Asn Phe Leu Ser Tyr Leu Val Glu Leu Gly Thr Gln
                  85                  90                  95    
 Pro Ala Thr His
             100



      <210> 926
      <211> 88
      <212> PRT
      <213> Homo sapiens


      <400> 926
 Met Asn Leu Val Gly Phe Cys Leu Phe Ile Cys Leu Leu Leu Met Leu
   1               5                  10                  15    
 Leu Leu Leu Leu Leu Phe Ser Lys Phe Ser Ile Val Glu Lys Tyr Ala
              20                  25                  30        
 Ala Pro Glu Glu Met Ile Gly His Ser Gln Ala Trp Cys Trp Ser Leu
          35                  40                  45            
 Ser Ser Leu Ala Gln Pro Ser Pro His Leu Ser Ala Tyr Leu Lys Leu
      50                  55                  60                
 Val Phe Tyr Ile Leu Gln Arg Arg Asn Gln Asn Asn Pro Asn Leu Thr
  65                  70                  75                  80
 Gln Ile Pro Gly Leu His Leu Ile
                  85            



      <210> 927
      <211> 130
      <212> PRT
      <213> Homo sapiens


      <400> 927
 Met Arg Leu Ser Trp Phe Arg Val Leu Thr Val Leu Ser Ile Cys Leu
   1               5                  10                  15    
 Ser Ala Val Ala Thr Ala Thr Gly Ala Glu Gly Lys Arg Lys Leu Gln
              20                  25                  30        
 Ile Gly Val Lys Lys Arg Val Asp His Cys Pro Ile Lys Ser Arg Lys
          35                  40                  45            
 Gly Asp Val Leu His Met His Tyr Thr Gly Lys Leu Glu Asp Gly Thr
      50                  55                  60                
 Glu Phe Asp Ser Ser Leu Pro Gln Asn Gln Pro Phe Val Phe Ser Leu
  65                  70                  75                  80
 Gly Thr Gly Gln Val Ile Lys Gly Trp Asp Gln Gly Leu Leu Gly Met
                  85                  90                  95    
 Cys Glu Gly Glu Lys Arg Lys Leu Val Ile Pro Ser Glu Leu Gly Gly
             100                 105                 110        
 Ala Thr Leu Val Phe Glu Val Glu Leu Leu Lys Ile Glu Arg Arg Thr
         115                 120                 125            
 Glu Leu
     130



      <210> 928
      <211> 68
      <212> PRT
      <213> Homo sapiens


      <400> 928
 Met Val Leu Pro Phe Leu Pro Ser Val Trp Asp Pro Ala Gly Val Leu
   1               5                  10                  15    
 Trp Phe Leu Ser Ser Gly Ser Arg Ala Val Leu Ser Asn Thr Val Thr
              20                  25                  30        
 Thr Cys Gly Cys Leu Lys Leu Ser Gln Leu Lys Ser His Lys Ile Lys
          35                  40                  45            
 Asn Ser Phe Leu Ser Cys Ser Asn Gln Val Ser Arg Gly Val Thr Val
      50                  55                  60                
 Cys Gly His Gly
  65            



      <210> 929
      <211> 105
      <212> PRT
      <213> Homo sapiens


      <400> 929
 Met Gln Cys Leu Tyr Phe Ile Leu Ile Leu Lys Gly Tyr Phe His Gln
   1               5                  10                  15    
 Gln His His Thr Leu Leu Ile Thr Ile Ala Leu Cys Phe Leu Gln Gln
              20                  25                  30        
 Gln Gln Glu Thr Asn Leu Leu Ala Asn Leu Thr Thr Asn Asp Ala Arg
          35                  40                  45            
 Asp Asn Ser Lys Asp Phe Gln Asn Ser Lys Val Gly Ala Ala Ala Thr
      50                  55                  60                
 Ser Arg Asp Glu Gly Cys Asn Cys Pro Ile Ile Gly Glu Ile Val Ile
  65                  70                  75                  80
 Ser Cys Tyr Trp Leu Phe Glu Ile Pro Pro Leu Met Ser Glu Leu Arg
                  85                  90                  95    
 Thr Pro Ala Pro Cys Asn Phe Lys Ile
             100                 105



      <210> 930
      <211> 648
      <212> PRT
      <213> Homo sapiens


      <400> 930
 Met Val Pro Ala His Leu Gly Thr Pro Val Ala Ala Ser Ala Ala Thr
   1               5                  10                  15    
 His Gly Thr Leu Gly Leu Leu Pro Pro Val Gly Cys Leu Pro Leu Gly
              20                  25                  30        
 Val Trp Ser Gly Cys Trp Gly Asp Thr Arg Gly Val Trp Ser Gly Asp
          35                  40                  45            
 Val Ala Arg Ser Glu Thr Gln Val Cys Ser Gly Leu Ser Thr Cys Pro
      50                  55                  60                
 Asn Gln Gly Gly Val Cys Val Asn Leu Thr His Met Asp Arg Ile Leu
  65                  70                  75                  80
 Glu Leu Asn Gln Glu Asp Phe Ser Val Val Val Glu Pro Gly Val Thr
                  85                  90                  95    
 Arg Lys Ala Leu Asn Ala His Leu Arg Asp Ser Gly Leu Trp Ile Pro
             100                 105                 110        
 Val Asp Pro Gly Ala Asp Ala Ser Leu Cys Gly Met Ala Ala Thr Gly
         115                 120                 125            
 Ala Ser Gly Thr Asn Ala Val Arg Tyr Gly Thr Met Arg Asp Asn Val
     130                 135                 140                
 Leu Thr Pro Ser Gly Gln Cys Leu Ala Met Ala Arg Leu Leu Arg Ser
 145                 150                 155                 160
 Ala Thr Trp Glu Leu Phe Pro Trp Arg Gly Tyr Cys Ser Gln Lys Ala
                 165                 170                 175    
 Lys Gly Glu Leu Cys Arg Asp Phe Val Glu Ala Leu Lys Ala Val Val
             180                 185                 190        
 Gly Gly Ser His Val Ser Thr Ala Ala Val Val Arg Glu Gln His Gly
         195                 200                 205            
 Arg Asp Glu Ser Val His Arg Cys Glu Pro Pro Asp Ala Val Val Trp
     210                 215                 220                
 Pro Gln Asn Val Glu Gln Val Ser Arg Leu Ala Ala Leu Cys Tyr Arg
 225                 230                 235                 240
 Gln Gly Val Pro Ile Ile Pro Phe Gly Thr Gly Thr Gly Leu Glu Gly
                 245                 250                 255    
 Gly Val Cys Ala Val Gln Gly Gly Val Cys Val Asn Leu Thr His Met
             260                 265                 270        
 Asp Arg Ile Leu Glu Leu Asn Gln Glu Asp Phe Ser Val Val Val Glu
         275                 280                 285            
 Pro Gly Val Thr Arg Lys Ala Leu Asn Ala His Leu Arg Asp Ser Gly
     290                 295                 300                
 Leu Trp Phe Pro Val Asp Pro Gly Ala Asp Ala Ser Leu Cys Gly Met
 305                 310                 315                 320
 Ala Ala Thr Gly Ala Ser Gly Thr Asn Ala Val Arg Tyr Gly Thr Met
                 325                 330                 335    
 Arg Asp Asn Val Leu Asn Leu Glu Val Val Leu Pro Asp Gly Arg Leu
             340                 345                 350        
 Leu His Thr Ala Gly Arg Gly Arg His Phe Arg Lys Ser Ala Ala Gly
         355                 360                 365            
 Tyr Asn Leu Thr Gly Leu Phe Val Gly Ser Glu Gly Thr Leu Gly Leu
     370                 375                 380                
 Ile Thr Ala Thr Thr Leu Arg Leu His Pro Ala Pro Glu Ala Thr Val
 385                 390                 395                 400
 Ala Ala Thr Cys Ala Phe Pro Ser Val Gln Ala Ala Val Asp Ser Thr
                 405                 410                 415    
 Val His Ile Leu Gln Ala Ala Val Pro Val Ala Arg Ile Glu Phe Leu
             420                 425                 430        
 Asp Glu Val Met Met Asp Ala Cys Asn Arg Tyr Ser Lys Leu Asn Cys
         435                 440                 445            
 Leu Val Ala Pro Thr Leu Phe Leu Glu Phe His Gly Ser Gln Gln Ala
     450                 455                 460                
 Leu Glu Glu Gln Leu Gln Arg Thr Glu Glu Ile Val Gln Gln Asn Gly
 465                 470                 475                 480
 Ala Ser Asp Phe Ser Trp Ala Lys Glu Ala Glu Glu Arg Ser Arg Leu
                 485                 490                 495    
 Trp Thr Ala Arg His Asn Ala Trp Tyr Ala Ala Leu Ala Thr Arg Pro
             500                 505                 510        
 Gly Cys Lys Ala Gly Val Thr His Arg Leu Pro Ser Asp Gln Gly Tyr
         515                 520                 525            
 Ser Thr Asp Val Cys Val Pro Ile Ser Arg Leu Pro Glu Ile Val Val
     530                 535                 540                
 Gln Thr Lys Glu Asp Leu Asn Ala Ser Gly Leu Thr Gly Ser Ile Val
 545                 550                 555                 560
 Gly His Val Gly Asp Gly Asn Phe His Cys Ile Leu Leu Val Asn Pro
                 565                 570                 575    
 Asp Asp Ala Glu Glu Leu Gly Arg Val Lys Ala Phe Ala Glu Gln Leu
             580                 585                 590        
 Gly Arg Arg Ala Leu Ala Leu His Gly Thr Cys Thr Gly Glu His Gly
         595                 600                 605            
 Ile Gly Met Gly Lys Arg Gln Leu Leu Gln Glu Glu Val Gly Ala Val
     610                 615                 620                
 Gly Val Glu Thr Met Arg Gln Leu Lys Ala Val Leu Asp Pro Gln Gly
 625                 630                 635                 640
 Leu Met Asn Pro Gly Lys Val Leu
                 645            



      <210> 931
      <211> 80
      <212> PRT
      <213> Homo sapiens


      <400> 931
 Met Glu Lys Pro Leu Phe Pro Leu Val Pro Leu His Trp Phe Gly Phe
   1               5                  10                  15    
 Gly Tyr Thr Ala Leu Val Val Ser Gly Gly Ile Val Gly Tyr Val Lys
              20                  25                  30        
 Thr Ala Ala Thr Ser Val Thr Phe Val Gly Val Met Gly Met Arg Ser
          35                  40                  45            
 Tyr Tyr Tyr Gly Lys Phe Met Pro Val Gly Leu Ile Ala Gly Ala Ser
      50                  55                  60                
 Leu Leu Met Ala Ala Lys Val Gly Val Arg Met Leu Met Thr Ser Asp
  65                  70                  75                  80





      <210> 932
      <211> 351
      <212> PRT
      <213> Homo sapiens


      <400> 932
 Met Ser Pro Gly Trp Ile Arg Leu Pro Thr Ser Ser Gln Thr Glu Ile
   1               5                  10                  15    
 Leu Met Leu Pro Val Leu Ser Ala Thr Leu Gln Val Arg Thr Ser Cys
              20                  25                  30        
 Pro Ser Phe Val Leu Val Thr Arg Pro Val Ser Ser Thr Met Lys Ile
          35                  40                  45            
 Arg Phe Arg Phe Leu Ser Pro Gly Leu Ile Ser Phe Thr Lys Val Ser
      50                  55                  60                
 Val Val Met Leu Pro Glu Pro Arg His Pro Thr Gly Trp Gly Ile Glu
  65                  70                  75                  80
 Asp Glu Gly Ser Met Leu Gly Ser Phe Ala Pro Met Leu His Phe Pro
                  85                  90                  95    
 Arg Pro Thr Tyr Pro Ile Arg Leu Gly Ser Gly Ser Leu Asn Pro Ser
             100                 105                 110        
 Asn Pro Ser Lys Arg Leu Lys Lys Asn Ile Pro Gly Gly Leu Gln Leu
         115                 120                 125            
 Gln Asp Gln Asn Leu Gly Val Ser Gly Gln Ala Ala Leu Gly Leu Glu
     130                 135                 140                
 Gly Pro Leu Pro Gly Cys Ser Phe Ser Leu Lys Pro Arg Ser Gly Gly
 145                 150                 155                 160
 Ala Asp Val Asp Arg Gly Arg Glu Pro Gly Ala Gln Pro Gly Ser Arg
                 165                 170                 175    
 Ile Leu Leu Ala Arg Ser Ser Gly Thr Leu Ile Pro Thr Ser Arg Asp
             180                 185                 190        
 Ser Val His Pro Leu Pro Tyr Pro Gln Pro Thr Thr His Pro Ser Gln
         195                 200                 205            
 Pro Ala Gly Leu Cys Thr Pro Leu Ser Ser Pro Gln Gly Glu Pro Gln
     210                 215                 220                
 Ala Pro Leu Pro Pro Asp Ala Ala Pro Trp Asn Ala Gly Val Arg Thr
 225                 230                 235                 240
 Phe Pro Glu Val Ser Pro Gly Trp Pro Pro Pro Ala Asn Gln His Arg
                 245                 250                 255    
 Pro Gly Ala Pro Cys Val Pro Pro Pro Ala Ser Pro Pro Arg Gly Arg
             260                 265                 270        
 Leu Val Asn Cys Asn Ile His Ser His Asp Arg Ser Gln Gly Val Thr
         275                 280                 285            
 Lys Leu Trp Asp Ala Asp Gln Gly Ser Gly Lys Gly Arg Gly Ala Gly
     290                 295                 300                
 Pro Ala Ala Gly His Ala Ala Gly Leu Pro Leu Arg Asn Asp Leu Ala
 305                 310                 315                 320
 Thr Ile Cys Val Ser Ser Lys Thr Gln Val Thr Cys Thr Pro Pro Lys
                 325                 330                 335    
 Arg Ser Val Ala Gly Gln Ala His Thr Phe Leu Pro Gly Arg Thr
             340                 345                 350    



      <210> 933
      <211> 498
      <212> PRT
      <213> Homo sapiens


      <400> 933
 Met Arg Pro Pro Ala Cys Trp Trp Leu Leu Ala Pro Pro Ala Leu Leu
   1               5                  10                  15    
 Ala Leu Leu Thr Cys Ser Leu Ala Phe Gly Leu Ala Ser Glu Asp Thr
              20                  25                  30        
 Lys Lys Glu Val Lys Gln Ser Gln Asp Leu Glu Lys Ser Gly Ile Ser
          35                  40                  45            
 Arg Lys Asn Asp Ile Asp Leu Lys Gly Ile Val Phe Val Ile Gln Ser
      50                  55                  60                
 Gln Ser Asn Ser Phe His Ala Lys Arg Ala Glu Gln Leu Lys Lys Ser
  65                  70                  75                  80
 Ile Leu Lys Gln Ala Ala Asp Leu Thr Gln Glu Leu Pro Ser Val Leu
                  85                  90                  95    
 Leu Leu His Gln Leu Ala Lys Gln Glu Gly Ala Trp Thr Ile Leu Pro
             100                 105                 110        
 Leu Leu Pro His Phe Ser Val Thr Tyr Ser Arg Asn Ser Ser Trp Ile
         115                 120                 125            
 Phe Phe Cys Glu Glu Glu Thr Arg Ile Gln Ile Pro Lys Leu Leu Glu
     130                 135                 140                
 Thr Leu Arg Arg Tyr Asp Pro Ser Lys Glu Trp Phe Leu Gly Lys Ala
 145                 150                 155                 160
 Leu His Asp Glu Glu Ala Thr Ile Ile His His Tyr Ala Phe Ser Glu
                 165                 170                 175    
 Asn Pro Thr Val Phe Lys Tyr Pro Asp Phe Ala Ala Gly Trp Ala Leu
             180                 185                 190        
 Ser Ile Pro Leu Val Asn Lys Leu Thr Lys Arg Leu Lys Ser Glu Ser
         195                 200                 205            
 Leu Lys Ser Asp Phe Thr Ile Asp Leu Lys His Glu Ile Ala Leu Tyr
     210                 215                 220                
 Ile Trp Asp Lys Gly Gly Gly Pro Pro Leu Thr Pro Val Pro Glu Phe
 225                 230                 235                 240
 Cys Thr Asn Asp Val Asp Phe Tyr Cys Ala Thr Thr Phe His Ser Phe
                 245                 250                 255    
 Leu Pro Leu Cys Arg Lys Pro Val Lys Lys Lys Asp Ile Phe Val Ala
             260                 265                 270        
 Val Lys Thr Cys Lys Lys Phe His Gly Asp Arg Ile Pro Ile Val Lys
         275                 280                 285            
 Gln Thr Trp Glu Ser Gln Ala Ser Leu Ile Glu Tyr Tyr Ser Asp Tyr
     290                 295                 300                
 Thr Glu Asn Ser Ile Pro Thr Val Asp Leu Gly Ile Pro Asn Thr Asp
 305                 310                 315                 320
 Arg Gly His Cys Gly Lys Thr Phe Ala Ile Leu Glu Arg Phe Leu Asn
                 325                 330                 335    
 Arg Ser Gln Asp Lys Thr Ala Trp Leu Val Ile Val Asp Asp Asp Thr
             340                 345                 350        
 Leu Ile Ser Ile Ser Arg Leu Gln His Leu Leu Ser Cys Tyr Asp Ser
         355                 360                 365            
 Gly Glu Pro Val Phe Leu Gly Glu Arg Tyr Gly Tyr Gly Leu Gly Thr
     370                 375                 380                
 Gly Gly Tyr Ser Tyr Ile Thr Gly Gly Gly Gly Met Val Phe Ser Arg
 385                 390                 395                 400
 Glu Ala Val Arg Arg Leu Leu Ala Ser Lys Cys Arg Cys Tyr Ser Asn
                 405                 410                 415    
 Asp Ala Pro Asp Asp Met Val Leu Gly Met Cys Phe Ser Gly Leu Gly
             420                 425                 430        
 Ile Pro Val Thr His Ser Pro Leu Phe His Gln Ala Arg Pro Val Asp
         435                 440                 445            
 Tyr Pro Lys Asp Tyr Leu Ser His Gln Val Pro Ile Ser Phe His Lys
     450                 455                 460                
 His Trp Asn Ile Asp Pro Val Lys Val Tyr Phe Thr Trp Leu Ala Pro
 465                 470                 475                 480
 Ser Asp Glu Asp Lys Ala Arg Gln Glu Thr Gln Lys Gly Phe Arg Glu
                 485                 490                 495    
 Glu Leu
        



      <210> 934
      <211> 420
      <212> PRT
      <213> Homo sapiens


      <400> 934
 Met Cys Ala Ala Gly Arg Ser Pro Trp Arg Ser Arg Cys Ala Leu Ala
   1               5                  10                  15    
 Ala Ala Ala Val Phe Ala Pro Val Ala Phe Leu Ser Ser Trp Ala Ala
              20                  25                  30        
 Pro Leu Gly Pro Gly Gly Gly Arg Gly Arg Pro Gln Gly Trp Arg Gly
          35                  40                  45            
 Val Pro Lys Ala Ala Ser Asp Leu Gly Pro Ser His Ala His Gly Gln
      50                  55                  60                
 Ala Gly Arg Leu Arg Ala Leu Pro Leu Lys Gly Gly Ala Cys Leu Val
  65                  70                  75                  80
 Ala Ser Ser Cys Thr Phe Cys Gly Leu Gln His Gly Thr Val Gln Ser
                  85                  90                  95    
 Phe Phe Phe Leu Leu Glu Cys Lys Tyr Gln Ser Arg Tyr Ile Glu Ile
             100                 105                 110        
 Arg Arg Ser Tyr Ser Val Gly Glu Ala Met Glu Glu Leu Leu Pro Asp
         115                 120                 125            
 Gly Gln Ile Trp Ala Asn Met Asp Pro Glu Glu Arg Met Leu Ala Ala
     130                 135                 140                
 Ala Thr Ala Phe Thr His Ile Cys Ala Gly Gln Gly Glu Gly Asp Val
 145                 150                 155                 160
 Arg Arg Glu Ala Gln Ser Ile Gln Tyr Asp Pro Tyr Ser Lys Ala Ser
                 165                 170                 175    
 Val Ala Pro Gly Lys Arg Pro Ala Leu Pro Val Gln Leu Gln Tyr Pro
             180                 185                 190        
 His Val Glu Ser Asn Val Pro Ser Glu Thr Val Ser Glu Ala Ser Gln
         195                 200                 205            
 Arg Leu Arg Lys Pro Val Met Lys Arg Lys Val Leu Arg Arg Lys Pro
     210                 215                 220                
 Asp Gly Glu Val Leu Val Thr Asp Glu Ser Ile Ile Ser Glu Ser Glu
 225                 230                 235                 240
 Ser Gly Thr Glu Asn Asp Gln Asp Leu Trp Asp Leu Arg Gln Arg Leu
                 245                 250                 255    
 Met Asn Val Gln Phe Gln Glu Asp Lys Glu Ser Ser Phe Asp Val Ser
             260                 265                 270        
 Gln Lys Phe Asn Leu Pro His Glu Tyr Gln Gly Ile Ser Gln Asp Gln
         275                 280                 285            
 Leu Ile Cys Ser Leu Gln Arg Glu Gly Met Gly Ser Pro Ala Tyr Glu
     290                 295                 300                
 Gln Asp Leu Ile Val Ala Ser Arg Pro Lys Ser Phe Ile Leu Pro Lys
 305                 310                 315                 320
 Leu Asp Gln Leu Ser Arg Asn Arg Gly Lys Thr Asp Arg Val Ala Arg
                 325                 330                 335    
 Tyr Phe Glu Tyr Lys Arg Asp Trp Asp Ser Ile Arg Leu Pro Gly Glu
             340                 345                 350        
 Asp His Arg Lys Glu Leu Arg Trp Gly Val Arg Glu Gln Met Leu Cys
         355                 360                 365            
 Arg Ala Glu Pro Gln Ser Lys Pro Gln His Ile Tyr Val Pro Asn Asn
     370                 375                 380                
 Tyr Leu Val Pro Thr Glu Lys Lys Arg Ser Ala Leu Arg Trp Gly Val
 385                 390                 395                 400
 Arg Cys Asp Leu Ala Asn Gly Val Ile Pro Arg Lys Leu Pro Phe Pro
                 405                 410                 415    
 Leu Ser Pro Ser
             420



      <210> 935
      <211> 576
      <212> PRT
      <213> Homo sapiens


      <400> 935
 Met Ala Gln Gly Val Leu Trp Ile Leu Leu Gly Leu Leu Leu Trp Ser
   1               5                  10                  15    
 Asp Pro Gly Thr Ala Ser Leu Pro Leu Leu Met Asp Ser Val Ile Gln
              20                  25                  30        
 Ala Leu Ala Glu Leu Glu Gln Lys Val Pro Ala Ala Lys Ala Arg His
          35                  40                  45            
 Thr Ala Ser Ala Trp Leu Met Ser Ala Pro Asn Ser Gly Pro His Asn
      50                  55                  60                
 Arg Leu Tyr His Phe Leu Leu Gly Ala Trp Ser Leu Asn Ala Thr Glu
  65                  70                  75                  80
 Leu Asp Pro Cys Pro Leu Ser Pro Glu Leu Leu Gly Leu Thr Lys Glu
                  85                  90                  95    
 Val Ala Gln His Asp Val Arg Glu Gly Lys Glu Tyr Gly Val Val Leu
             100                 105                 110        
 Ala Pro Asp Gly Ser Thr Val Ala Val Glu Pro Leu Leu Ala Gly Leu
         115                 120                 125            
 Glu Ala Gly Leu Gln Gly Arg Arg Val Ile Asn Leu Pro Leu Asp Ser
     130                 135                 140                
 Met Ala Ala Pro Trp Glu Thr Gly Asp Thr Phe Pro Asp Val Val Ala
 145                 150                 155                 160
 Ile Ala Pro Asp Val Arg Ala Thr Ser Ser Pro Gly Leu Arg Asp Gly
                 165                 170                 175    
 Ser Pro Asp Val Thr Thr Ala Asp Ile Gly Ala Asn Thr Pro Asp Ala
             180                 185                 190        
 Thr Lys Gly Cys Pro Asp Val Gln Ala Ser Leu Pro Asp Ala Lys Ala
         195                 200                 205            
 Lys Ser Pro Pro Thr Met Val Asp Ser Leu Leu Ala Val Thr Leu Ala
     210                 215                 220                
 Gly Asn Leu Gly Leu Thr Phe Leu Arg Gly Ser Gln Thr Gln Ser His
 225                 230                 235                 240
 Pro Asp Leu Gly Thr Glu Gly Cys Trp Asp Gln Leu Ser Ala Pro Arg
                 245                 250                 255    
 Thr Phe Thr Leu Leu Asp Pro Lys Ala Ser Leu Leu Thr Met Ala Phe
             260                 265                 270        
 Leu Asn Gly Ala Leu Asp Gly Val Ile Leu Gly Asp Tyr Leu Ser Arg
         275                 280                 285            
 Thr Pro Glu Pro Arg Pro Ser Leu Ser His Leu Leu Ser Gln Tyr Tyr
     290                 295                 300                
 Gly Ala Gly Val Ala Arg Asp Pro Gly Phe Arg Ser Asn Phe Arg Arg
 305                 310                 315                 320
 Gln Asn Gly Ala Ala Leu Thr Ser Ala Ser Ile Leu Ala Gln Gln Val
                 325                 330                 335    
 Trp Gly Thr Leu Val Leu Leu Gln Arg Leu Glu Pro Val His Leu Gln
             340                 345                 350        
 Leu Gln Cys Met Ser Gln Glu Gln Leu Ala Gln Val Ala Ala Asn Ala
         355                 360                 365            
 Thr Lys Glu Phe Thr Glu Ala Phe Leu Gly Cys Pro Ala Ile His Pro
     370                 375                 380                
 Arg Cys Arg Trp Gly Ala Ala Pro Tyr Arg Gly Arg Pro Lys Leu Leu
 385                 390                 395                 400
 Gln Leu Pro Leu Gly Phe Leu Tyr Val His His Thr Tyr Val Pro Ala
                 405                 410                 415    
 Pro Pro Cys Thr Asp Phe Thr Arg Cys Ala Ala Asn Met Arg Ser Met
             420                 425                 430        
 Gln Arg Tyr His Gln Asp Thr Gln Gly Trp Gly Asp Ile Gly Tyr Ser
         435                 440                 445            
 Phe Val Val Gly Ser Asp Gly Tyr Val Tyr Glu Gly Arg Gly Trp His
     450                 455                 460                
 Trp Val Gly Ala His Thr Leu Gly His Asn Ser Arg Gly Phe Gly Val
 465                 470                 475                 480
 Ala Ile Val Gly Asn Tyr Thr Ala Ala Leu Pro Thr Glu Ala Ala Leu
                 485                 490                 495    
 Arg Thr Val Arg Asp Thr Leu Pro Ser Cys Ala Val Arg Ala Gly Leu
             500                 505                 510        
 Leu Arg Pro Asp Tyr Ala Leu Leu Gly His Arg Gln Leu Val Arg Thr
         515                 520                 525            
 Asp Cys Pro Gly Asp Ala Leu Phe Asp Leu Leu Arg Thr Trp Pro His
     530                 535                 540                
 Phe Thr Ala Thr Val Lys Pro Arg Pro Ala Arg Ser Val Ser Lys Arg
 545                 550                 555                 560
 Ser Arg Arg Glu Pro Pro Pro Arg Thr Leu Pro Ala Thr Asp Leu Gln
                 565                 570                 575    





      <210> 936
      <211> 175
      <212> PRT
      <213> Homo sapiens


      <400> 936
 Met Ala Thr Pro Arg Gly Leu Val Ala Leu Leu Leu Leu Leu Leu Leu
   1               5                  10                  15    
 Pro Thr Ser Gly Gln Glu Lys Pro Thr Glu Gly Pro Arg Asn Thr Cys
              20                  25                  30        
 Leu Gly Ser Asn Asn Met Tyr Asp Ile Phe Asn Leu Asn Asp Lys Ala
          35                  40                  45            
 Leu Cys Phe Thr Lys Cys Arg Gln Ser Gly Ser Asp Ser Cys Asn Val
      50                  55                  60                
 Glu Asn Leu Gln Arg Tyr Trp Leu Asn Tyr Glu Ala His Leu Met Lys
  65                  70                  75                  80
 Glu Gly Leu Thr Gln Lys Val Asn Thr Pro Phe Leu Lys Ala Leu Val
                  85                  90                  95    
 Gln Asn Leu Ser Thr Asn Thr Ala Glu Asp Phe Tyr Phe Ser Leu Glu
             100                 105                 110        
 Pro Ser Gln Val Pro Arg Gln Val Met Lys Asp Glu Asp Lys Pro Pro
         115                 120                 125            
 Asp Arg Val Arg Leu Pro Lys Ser Leu Phe Arg Ser Leu Pro Gly Asn
     130                 135                 140                
 Arg Ser Val Val Arg Leu Ala Val Thr Ile Leu Asp Ile Gly Pro Gly
 145                 150                 155                 160
 Thr Leu Phe Lys Val Arg Thr Gln Gly Ser Ser Lys Val Lys Cys
                 165                 170                 175



      <210> 937
      <211> 287
      <212> PRT
      <213> Homo sapiens


      <400> 937
 Met Phe Ala Cys Phe Trp Gly Pro Ser Gln Ala Arg Ser Leu Thr Trp
   1               5                  10                  15    
 Met Glu Trp Arg Val Ser Gly Trp Gly Tyr Asp Asn Ala Leu Pro Val
              20                  25                  30        
 Gln Pro Pro Ser Pro Arg Pro Leu His Arg Leu Arg Ser Leu Leu Pro
          35                  40                  45            
 Gly Phe Pro Phe Ser Thr Ser Ile Ser Ala Glu Arg Tyr Asp Asp Met
      50                  55                  60                
 Ala Ser Ala Met Lys Ala Val Thr Glu Leu Asn Glu Pro Leu Ser Asn
  65                  70                  75                  80
 Glu Asp Arg Asn Leu Leu Ser Val Ala Tyr Lys Asn Val Val Gly Ala
                  85                  90                  95    
 Arg Arg Ser Ser Trp Arg Val Ile Ser Ser Ile Glu Gln Lys Thr Met
             100                 105                 110        
 Ala Asp Gly Asn Glu Lys Lys Leu Glu Lys Val Lys Ala Tyr Arg Glu
         115                 120                 125            
 Lys Ile Glu Lys Glu Leu Glu Thr Val Cys Asn Asp Val Leu Ser Leu
     130                 135                 140                
 Leu Asp Lys Phe Leu Ile Lys Asn Cys Asn Asp Phe Gln Tyr Glu Ser
 145                 150                 155                 160
 Lys Val Phe Tyr Leu Lys Met Lys Gly Asp Tyr Tyr Arg Tyr Leu Ala
                 165                 170                 175    
 Glu Val Ala Ser Gly Glu Lys Lys Asn Ser Val Val Glu Ala Ser Glu
             180                 185                 190        
 Ala Ala Tyr Lys Glu Ala Phe Glu Ile Ser Lys Glu Gln Met Gln Pro
         195                 200                 205            
 Thr His Pro Ile Arg Leu Gly Leu Ala Leu Asn Phe Ser Val Phe Tyr
     210                 215                 220                
 Tyr Glu Ile Gln Asn Ala Pro Ala Arg Thr Pro Leu Leu Asp Gln Lys
 225                 230                 235                 240
 Ala Leu Gly Phe Arg Arg Ala Glu Leu Asp Thr Leu Asn Glu Asp Ser
                 245                 250                 255    
 Tyr Lys Asp Ser Thr Leu Ile Met Gln Leu Leu Arg Asp Asn Leu Thr
             260                 265                 270        
 Leu Trp Thr Ser Asp Gln Gln Asp Glu Glu Ala Gly Glu Gly Asn
         275                 280                 285        



      <210> 938
      <211> 153
      <212> PRT
      <213> Homo sapiens


      <400> 938
 Met Thr Val Ser Val Thr Gly Lys Val Trp Arg Phe Leu Ile Ser Leu
   1               5                  10                  15    
 Met Phe Lys Glu Leu Val Ala Gly Ser Ser Asn His Gly Asn Lys Gly
              20                  25                  30        
 His Glu Phe Leu Glu Val Thr Phe Ala Val Ser Ile Ile Val Gln Cys
          35                  40                  45            
 Phe His Asp Phe Val His Asn Leu Leu Leu Phe Asp Phe Met Ser Glu
      50                  55                  60                
 Leu Glu Lys Ala Met Val Ala Leu Ile Asp Val Phe His Gln Tyr Ser
  65                  70                  75                  80
 Gly Arg Glu Gly Asp Lys His Lys Leu Lys Lys Ser Glu Leu Lys Glu
                  85                  90                  95    
 Leu Ile Asn Asn Glu Leu Ser His Phe Leu Glu Glu Ile Lys Glu Gln
             100                 105                 110        
 Glu Val Val Asp Lys Val Met Glu Thr Leu Asp Asn Asp Gly Asp Gly
         115                 120                 125            
 Glu Cys Asp Phe Gln Glu Phe Met Ala Phe Val Ala Met Val Thr Thr
     130                 135                 140                
 Ala Cys His Glu Phe Phe Glu His Glu
 145                 150            



      <210> 939
      <211> 81
      <212> PRT
      <213> Homo sapiens


      <400> 939
 Met Trp Pro Thr Leu Leu Leu Leu Leu Met Leu Phe Arg Ala Ala Pro
   1               5                  10                  15    
 Val Pro Thr Ala Lys Ala Ala Pro His Pro Asp Ala Asn Thr Gln Glu
              20                  25                  30        
 Gly Leu Gln Asn Leu Leu Gln Gly Val Gly Ala Gly Gly Asp Gly Glu
          35                  40                  45            
 Leu Arg Ala Asp Ser His Leu Ala Pro Gly Ser Gly Cys Ile Asp Gly
      50                  55                  60                
 Ala Val Val Ala Thr Arg Pro Glu Ser Arg Gly Gly Lys Thr Ala Val
  65                  70                  75                  80
 Pro
    



      <210> 940
      <211> 708
      <212> PRT
      <213> Homo sapiens


      <400> 940
 Met Leu Arg Met Arg Val Pro Ala Leu Leu Val Leu Leu Phe Cys Phe
   1               5                  10                  15    
 Arg Gly Arg Ala Gly Pro Ser Pro His Phe Leu Gln Gln Pro Glu Asp
              20                  25                  30        
 Leu Val Val Leu Leu Gly Glu Glu Ala Arg Leu Pro Cys Ala Leu Gly
          35                  40                  45            
 Ala Tyr Trp Gly Leu Val Gln Trp Thr Lys Ser Gly Leu Ala Leu Gly
      50                  55                  60                
 Gly Gln Arg Asp Leu Pro Gly Trp Ser Arg Tyr Trp Ile Ser Gly Asn
  65                  70                  75                  80
 Ala Ala Asn Gly Gln His Asp Leu His Ile Arg Pro Val Glu Leu Glu
                  85                  90                  95    
 Asp Glu Ala Ser Tyr Glu Cys Gln Ala Thr Gln Ala Gly Leu Arg Ser
             100                 105                 110        
 Arg Pro Ala Gln Leu His Val Leu Val Pro Pro Glu Ala Pro Gln Val
         115                 120                 125            
 Leu Gly Gly Pro Ser Val Ser Leu Val Ala Gly Val Pro Ala Asn Leu
     130                 135                 140                
 Thr Cys Arg Ser Arg Gly Asp Ala Arg Pro Thr Pro Glu Leu Leu Trp
 145                 150                 155                 160
 Phe Arg Asp Gly Val Leu Leu Asp Gly Ala Thr Phe His Gln Thr Leu
                 165                 170                 175    
 Leu Lys Glu Gly Thr Pro Gly Ser Val Glu Ser Thr Leu Thr Leu Thr
             180                 185                 190        
 Pro Phe Ser His Asp Asp Gly Ala Thr Phe Val Cys Arg Ala Arg Ser
         195                 200                 205            
 Gln Ala Leu Pro Thr Gly Arg Asp Thr Ala Ile Thr Leu Ser Leu Gln
     210                 215                 220                
 Tyr Pro Pro Glu Val Thr Leu Ser Ala Ser Pro His Thr Val Gln Glu
 225                 230                 235                 240
 Gly Glu Lys Val Ile Phe Leu Cys Gln Ala Thr Ala Gln Pro Pro Val
                 245                 250                 255    
 Thr Gly Tyr Arg Trp Ala Lys Gly Gly Ser Pro Val Leu Gly Ala Arg
             260                 265                 270        
 Gly Pro Arg Leu Glu Val Val Ala Asp Ala Ser Phe Leu Thr Glu Pro
         275                 280                 285            
 Val Ser Cys Glu Val Ser Asn Ala Val Gly Ser Ala Asn Arg Ser Thr
     290                 295                 300                
 Ala Leu Asp Val Leu Phe Gly Pro Ile Leu Gln Ala Lys Pro Glu Pro
 305                 310                 315                 320
 Val Ser Val Asp Val Gly Glu Asp Ala Ser Phe Ser Cys Ala Trp Arg
                 325                 330                 335    
 Gly Asn Pro Leu Pro Arg Val Thr Trp Thr Arg Arg Gly Gly Ala Gln
             340                 345                 350        
 Val Leu Gly Ser Gly Ala Thr Leu Arg Leu Pro Ser Val Gly Pro Glu
         355                 360                 365            
 Asp Ala Gly Asp Tyr Val Cys Arg Ala Glu Ala Gly Leu Ser Gly Leu
     370                 375                 380                
 Arg Gly Gly Ala Ala Glu Ala Arg Leu Thr Val Asn Ala Pro Pro Val
 385                 390                 395                 400
 Val Thr Ala Leu His Ser Ala Pro Ala Phe Leu Arg Gly Pro Ala Arg
                 405                 410                 415    
 Leu Gln Cys Leu Val Phe Ala Ser Pro Ala Pro Asp Ala Val Val Trp
             420                 425                 430        
 Ser Trp Asp Glu Gly Phe Leu Glu Ala Gly Ser Gln Gly Arg Phe Leu
         435                 440                 445            
 Val Glu Thr Phe Pro Ala Pro Glu Ser Arg Gly Gly Leu Gly Pro Gly
     450                 455                 460                
 Leu Ile Ser Val Leu His Ile Ser Gly Thr Gln Glu Ser Asp Phe Ser
 465                 470                 475                 480
 Arg Ser Phe Asn Cys Ser Ala Arg Asn Arg Leu Gly Glu Gly Gly Ala
                 485                 490                 495    
 Gln Ala Ser Leu Gly Arg Arg Asp Leu Leu Pro Thr Val Arg Ile Val
             500                 505                 510        
 Ala Gly Val Ala Ala Ala Thr Thr Thr Leu Leu Met Val Ile Thr Gly
         515                 520                 525            
 Val Ala Leu Cys Cys Trp Arg His Ser Lys Ala Ser Ala Ser Phe Ser
     530                 535                 540                
 Glu Gln Lys Asn Leu Met Arg Ile Pro Gly Ser Ser Asp Gly Ser Ser
 545                 550                 555                 560
 Ser Arg Gly Pro Glu Glu Glu Glu Thr Gly Ser Arg Glu Asp Arg Gly
                 565                 570                 575    
 Pro Ile Val His Thr Asp His Ser Asp Leu Val Leu Glu Glu Glu Gly
             580                 585                 590        
 Thr Leu Glu Thr Lys Asp Pro Thr Asn Gly Tyr Tyr Lys Val Arg Gly
         595                 600                 605            
 Val Ser Val Ser Leu Ser Leu Gly Glu Ala Pro Gly Gly Gly Leu Phe
     610                 615                 620                
 Leu Pro Pro Pro Ser Pro Leu Gly Pro Pro Gly Thr Pro Thr Phe Tyr
 625                 630                 635                 640
 Asp Phe Asn Pro His Leu Gly Met Val Pro Pro Cys Arg Leu Tyr Arg
                 645                 650                 655    
 Ala Arg Ala Gly Tyr Leu Thr Thr Pro His Pro Arg Ala Phe Thr Ser
             660                 665                 670        
 Tyr Ile Lys Pro Thr Ser Phe Gly Pro Pro Asp Leu Ala Pro Gly Thr
         675                 680                 685            
 Pro Pro Phe Pro Tyr Ala Ala Phe Pro Thr Pro Ser His Pro Arg Leu
     690                 695                 700                
 Gln Thr His Val
 705            



      <210> 941
      <211> 401
      <212> PRT
      <213> Homo sapiens


      <400> 941
 Met Leu Leu Ala Leu Pro Leu Ala Ala Pro Ser Cys Pro Met Leu Cys
   1               5                  10                  15    
 Thr Cys Tyr Ser Ser Pro Pro Thr Val Ser Cys Gln Ala Asn Asn Phe
              20                  25                  30        
 Ser Ser Val Pro Leu Ser Leu Pro Pro Ser Thr Gln Arg Leu Phe Leu
          35                  40                  45            
 Gln Asn Asn Leu Ile Arg Thr Leu Arg Pro Gly Thr Phe Gly Ser Asn
      50                  55                  60                
 Leu Leu Thr Leu Trp Leu Phe Ser Asn Asn Leu Ser Thr Ile Tyr Pro
  65                  70                  75                  80
 Gly Thr Phe Arg His Leu Gln Ala Leu Glu Glu Leu Asp Leu Gly Asp
                  85                  90                  95    
 Asn Arg His Leu Arg Ser Leu Glu Pro Asp Thr Phe Gln Gly Leu Glu
             100                 105                 110        
 Arg Leu Gln Ser Leu His Leu Tyr Arg Cys Gln Leu Ser Ser Leu Pro
         115                 120                 125            
 Gly Asn Ile Phe Arg Gly Leu Val Ser Leu Gln Tyr Leu Tyr Leu Gln
     130                 135                 140                
 Glu Asn Ser Leu Leu His Leu Gln Asp Asp Leu Phe Ala Asp Leu Ala
 145                 150                 155                 160
 Asn Leu Ser His Leu Phe Leu His Gly Asn Arg Leu Arg Leu Leu Thr
                 165                 170                 175    
 Glu His Val Phe Arg Gly Leu Gly Ser Leu Asp Arg Leu Leu Leu His
             180                 185                 190        
 Gly Asn Arg Leu Gln Gly Val His Arg Ala Ala Phe Arg Gly Leu Ser
         195                 200                 205            
 Arg Leu Thr Ile Leu Tyr Leu Phe Asn Asn Ser Leu Ala Ser Leu Pro
     210                 215                 220                
 Gly Glu Ala Leu Ala Asp Leu Pro Ser Leu Glu Phe Leu Arg Leu Asn
 225                 230                 235                 240
 Ala Asn Pro Trp Ala Cys Asp Cys Arg Ala Arg Pro Leu Trp Ala Trp
                 245                 250                 255    
 Phe Gln Arg Ala Arg Val Ser Ser Ser Asp Val Thr Cys Ala Thr Pro
             260                 265                 270        
 Pro Glu Arg Gln Gly Arg Asp Leu Arg Ala Leu Arg Glu Ala Asp Phe
         275                 280                 285            
 Gln Ala Cys Pro Pro Ala Ala Pro Thr Arg Pro Gly Ser Arg Ala Arg
     290                 295                 300                
 Gly Asn Ser Ser Ser Asn His Leu Tyr Gly Val Ala Glu Ala Gly Ala
 305                 310                 315                 320
 Pro Pro Ala Asp Pro Ser Thr Leu Tyr Arg Asp Leu Pro Ala Glu Asp
                 325                 330                 335    
 Ser Arg Gly Arg Gln Gly Gly Asp Ala Pro Thr Glu Asp Asp Tyr Trp
             340                 345                 350        
 Gly Gly Tyr Gly Gly Glu Asp Gln Arg Gly Glu Gln Met Cys Pro Gly
         355                 360                 365            
 Ala Ala Cys Gln Ala Pro Pro Asp Ser Arg Gly Pro Ala Leu Ser Ala
     370                 375                 380                
 Gly Leu Pro Ser Pro Leu Leu Cys Leu Leu Leu Leu Val Pro His His
 385                 390                 395                 400
 Leu
    



      <210> 942
      <211> 160
      <212> PRT
      <213> Homo sapiens


      <400> 942
 Met Val Tyr Ser Ala Met Trp Trp Met Ala Thr Cys Leu Leu Ser His
   1               5                  10                  15    
 Leu Pro Ser Asp Cys Trp Thr Asp Ser Leu Ala Leu Ser Trp Cys Ser
              20                  25                  30        
 Pro Arg Glu Ala Gln Ser His Ser Pro Arg Ala Gln Pro Ser Ser Pro
          35                  40                  45            
 Thr Thr Ser Gln Ala Trp Ser His Glu Met Leu Pro Ser Thr Trp Gln
      50                  55                  60                
 Asn Gly Pro Ser Arg Thr Arg Gln Pro Ser Leu Ile Gly Asp Leu Gly
  65                  70                  75                  80
 Ala His Gly Arg Thr Pro Arg Gln Ala His Pro Gly Ala Val Thr Asp
                  85                  90                  95    
 Met Val Pro Phe Pro Pro Ala Arg Thr Val Leu Glu Leu Gly Ser Gly
             100                 105                 110        
 Ala Ser Leu Thr Gly Leu Ala Ile Cys Lys Met Cys Arg Leu Gln Ala
         115                 120                 125            
 Tyr Ile Phe Ser Asp Cys His Ser Gln Val Leu Glu Lys Leu Arg Gly
     130                 135                 140                
 Asn Val Leu Leu Asn Gly Leu Ser Leu Glu Ala Ala Ser Leu Pro Thr
 145                 150                 155                 160





      <210> 943
      <211> 161
      <212> PRT
      <213> Homo sapiens


      <400> 943
 Met His Trp Leu Arg Lys Val Gln Gly Leu Cys Thr Leu Trp Gly Thr
   1               5                  10                  15    
 Gln Met Ser Ser Arg Thr Leu Tyr Ile Asn Ser Arg Gln Leu Val Ser
              20                  25                  30        
 Leu Gln Trp Gly His Gln Glu Val Pro Ala Lys Phe Asn Phe Ala Ser
          35                  40                  45            
 Asp Val Leu Asp His Trp Ala Asp Met Glu Lys Ala Gly Lys Arg Leu
      50                  55                  60                
 Pro Ser Pro Ala Leu Trp Trp Val Asn Gly Lys Gly Lys Glu Leu Met
  65                  70                  75                  80
 Trp Asn Phe Arg Glu Leu Ser Glu Asn Ser Gln Gln Ala Ala Asn Val
                  85                  90                  95    
 Leu Ser Gly Ala Cys Gly Leu Gln Arg Gly Asp Arg Val Ala Val Met
             100                 105                 110        
 Leu Pro Arg Val Pro Glu Trp Trp Leu Val Ile Leu Gly Cys Ile Arg
         115                 120                 125            
 Ala Gly Leu Ile Phe Met Pro Gly Thr Ile Gln Met Lys Ser Thr Asp
     130                 135                 140                
 Ile Leu Tyr Lys Leu Gln Met Ser Lys Ala Lys Ala Ile Val Ala Gly
 145                 150                 155                 160
 Gly
    



      <210> 944
      <211> 534
      <212> PRT
      <213> Homo sapiens


      <400> 944
 Met Gly Ala Gly Pro Gly Arg Cys Gly Gly Pro Trp Ala Pro Arg Val
   1               5                  10                  15    
 Gly Ala Gly Ser Glu Ala Gly Trp Leu Arg Arg Ser Ala Asp Val Ala
              20                  25                  30        
 Ala Gln Met Ala Ser Arg Leu Thr Leu Leu Thr Leu Leu Leu Leu Leu
          35                  40                  45            
 Leu Ala Gly Asp Arg Ala Ser Ser Asn Pro Asn Ala Thr Ser Ser Ser
      50                  55                  60                
 Ser Gln Asp Pro Glu Ser Leu Gln Asp Arg Gly Glu Gly Lys Val Ala
  65                  70                  75                  80
 Thr Thr Val Ile Ser Lys Met Leu Phe Val Glu Pro Ile Leu Glu Val
                  85                  90                  95    
 Ser Ser Leu Pro Thr Thr Asn Ser Thr Thr Asn Ser Ala Thr Lys Ile
             100                 105                 110        
 Thr Ala Asn Thr Thr Asp Glu Pro Thr Thr Gln Pro Thr Thr Glu Pro
         115                 120                 125            
 Thr Thr Gln Pro Thr Ile Gln Pro Thr Gln Pro Thr Thr Gln Leu Pro
     130                 135                 140                
 Thr Asp Ser Pro Thr Gln Pro Thr Thr Gly Ser Phe Cys Pro Gly Pro
 145                 150                 155                 160
 Val Thr Leu Cys Ser Asp Leu Glu Ser His Ser Thr Glu Ala Val Leu
                 165                 170                 175    
 Gly Asp Ala Leu Val Asp Phe Ser Leu Lys Leu Tyr His Ala Phe Ser
             180                 185                 190        
 Ala Met Lys Lys Val Glu Thr Asn Met Ala Phe Ser Pro Phe Ser Ile
         195                 200                 205            
 Ala Ser Leu Leu Thr Gln Val Leu Leu Gly Ala Gly Glu Asn Thr Lys
     210                 215                 220                
 Thr Asn Leu Glu Ser Ile Leu Ser Tyr Pro Lys Asp Phe Thr Cys Val
 225                 230                 235                 240
 His Gln Ala Leu Lys Gly Phe Thr Thr Lys Gly Val Thr Ser Val Ser
                 245                 250                 255    
 Gln Ile Phe His Ser Pro Asp Leu Ala Ile Arg Asp Thr Phe Val Asn
             260                 265                 270        
 Ala Ser Arg Thr Leu Tyr Ser Ser Ser Pro Arg Val Leu Ser Asn Asn
         275                 280                 285            
 Ser Asp Ala Asn Leu Glu Leu Ile Asn Thr Trp Val Ala Lys Asn Thr
     290                 295                 300                
 Asn Asn Lys Ile Ser Arg Leu Leu Asp Ser Leu Pro Ser Asp Thr Arg
 305                 310                 315                 320
 Leu Val Leu Leu Asn Ala Ile Tyr Leu Ser Ala Lys Trp Lys Thr Thr
                 325                 330                 335    
 Phe Asp Pro Lys Lys Thr Arg Met Glu Pro Phe His Phe Lys Asn Ser
             340                 345                 350        
 Val Ile Lys Val Pro Met Met Asn Ser Lys Lys Tyr Pro Val Ala His
         355                 360                 365            
 Phe Ile Asp Gln Thr Leu Lys Ala Lys Val Gly Gln Leu Gln Leu Ser
     370                 375                 380                
 His Asn Leu Ser Leu Val Ile Leu Val Pro Gln Asn Leu Lys His Arg
 385                 390                 395                 400
 Leu Glu Asp Met Glu Gln Ala Leu Ser Pro Ser Val Phe Lys Ala Ile
                 405                 410                 415    
 Met Glu Lys Leu Glu Met Ser Lys Phe Gln Pro Thr Leu Leu Thr Leu
             420                 425                 430        
 Pro Arg Ile Lys Val Thr Thr Ser Gln Asp Met Leu Ser Ile Met Glu
         435                 440                 445            
 Lys Leu Glu Phe Phe Asp Phe Ser Tyr Asp Leu Asn Leu Cys Gly Leu
     450                 455                 460                
 Thr Glu Asp Pro Asp Leu Gln Val Ser Ala Met Gln His Gln Thr Val
 465                 470                 475                 480
 Leu Glu Leu Thr Glu Thr Gly Val Glu Ala Ala Ala Ala Ser Ala Ile
                 485                 490                 495    
 Ser Val Ala Arg Thr Leu Leu Val Phe Glu Val Gln Gln Pro Phe Leu
             500                 505                 510        
 Phe Val Leu Trp Asp Gln Gln His Lys Phe Pro Val Phe Met Gly Arg
         515                 520                 525            
 Val Tyr Asp Pro Arg Ala
     530                



      <210> 945
      <211> 236
      <212> PRT
      <213> Homo sapiens


      <400> 945
 Met Ala Leu Ser Leu Gly Trp Lys Ala His Arg Asn His Cys Gly Leu
   1               5                  10                  15    
 Leu Leu Gln Ala Leu Arg Ser Ser Gly Leu Leu Leu Phe Pro Cys Gly
              20                  25                  30        
 Gln Cys Pro Trp Arg Gly Ala Gly Ser Phe Leu Asp Pro Glu Ile Lys
          35                  40                  45            
 Ala Phe Leu Glu Glu Asn Thr Glu Val Thr Ser Ser Gly Ser Leu Thr
      50                  55                  60                
 Pro Glu Ile Gln Leu Arg Leu Leu Thr Pro Arg Cys Lys Phe Trp Tyr
  65                  70                  75                  80
 Leu Leu Asp Asn Pro Asp Val Val Arg Gly Lys Ser Val Leu Asp Leu
                  85                  90                  95    
 Gly Ser Gly Cys Gly Ala Thr Ala Ile Ala Ala Lys Met Ser Gly Ala
             100                 105                 110        
 Ser Arg Ile Leu Ala Asn Asp Ile Asp Pro Ile Ala Gly Met Ala Ile
         115                 120                 125            
 Thr Leu Asn Cys Glu Leu Asn Arg Leu Asn Pro Phe Pro Ile Leu Ile
     130                 135                 140                
 Gln Asn Ile Leu Asn Leu Glu Gln Asp Lys Trp Asp Leu Val Val Leu
 145                 150                 155                 160
 Gly Asp Met Phe Tyr Asp Glu Asp Leu Ala Asp Ser Leu His Gln Trp
                 165                 170                 175    
 Leu Lys Lys Cys Phe Trp Thr Tyr Arg Thr Arg Val Leu Ile Gly Asp
             180                 185                 190        
 Pro Gly Arg Pro Gln Phe Ser Gly His Ser Ile Gln His His Leu His
         195                 200                 205            
 Lys Val Val Glu Tyr Ser Leu Leu Glu Ser Thr Arg Gln Glu Asn Ser
     210                 215                 220                
 Gly Leu Thr Thr Ser Thr Val Trp Gly Phe Gln Pro
 225                 230                 235    



      <210> 946
      <211> 136
      <212> PRT
      <213> Homo sapiens


      <400> 946
 Met Thr Lys Val Pro Ser Cys Phe Leu Leu Pro Val Leu Leu Leu Gly
   1               5                  10                  15    
 Arg Lys Arg Gly Leu Met Arg Leu His Ser Gly Ala His Ile Thr Gly
              20                  25                  30        
 Ala Ser Ala Gly Thr Gly Leu Ala Ala Cys Ser Gln Glu Lys Val Ser
          35                  40                  45            
 Glu Lys Glu Cys Met Ser Val Ser Val Cys Ala Trp Lys Leu Gly His
      50                  55                  60                
 Trp Ala Ser Asp Ser Leu Pro Thr Gln Glu Arg Lys Asp Pro Ser Pro
  65                  70                  75                  80
 Pro Pro Leu Val Arg Gln Phe Thr Leu Pro Thr Cys His Val Phe Ala
                  85                  90                  95    
 Lys Thr Lys Ile Leu Lys Glu Met Ser Gly Gln Arg Gln Gly Pro Gly
             100                 105                 110        
 His Val Ala Cys Pro Ala Ser Met Ser Leu Gly Gly Gly Val Gly Trp
         115                 120                 125            
 Gly Trp Ala Ala Ala Ser Gln Pro
     130                 135    



      <210> 947
      <211> 658
      <212> PRT
      <213> Homo sapiens


      <400> 947
 Met Met Glu Glu Arg Ala Asn Leu Met His Met Met Lys Leu Ser Ile
   1               5                  10                  15    
 Lys Val Leu Leu Gln Ser Ala Leu Ser Leu Gly Arg Ser Leu Asp Ala
              20                  25                  30        
 Asp His Ala Pro Leu Gln Gln Phe Phe Val Val Met Glu His Cys Leu
          35                  40                  45            
 Lys His Gly Leu Lys Val Lys Lys Ser Phe Ile Gly Gln Asn Lys Ser
      50                  55                  60                
 Phe Phe Gly Pro Leu Glu Leu Val Glu Lys Leu Cys Pro Glu Ala Ser
  65                  70                  75                  80
 Asp Ile Ala Thr Ser Val Arg Asn Leu Pro Glu Leu Lys Thr Ala Val
                  85                  90                  95    
 Gly Arg Gly Arg Ala Trp Leu Tyr Leu Ala Leu Met Gln Lys Lys Leu
             100                 105                 110        
 Ala Asp Tyr Leu Lys Val Leu Ile Asp Asn Lys His Leu Leu Ser Glu
         115                 120                 125            
 Phe Tyr Glu Pro Glu Ala Leu Met Met Glu Glu Glu Gly Met Val Ile
     130                 135                 140                
 Val Gly Leu Leu Val Gly Leu Asn Val Leu Asp Ala Asn Leu Cys Leu
 145                 150                 155                 160
 Lys Gly Glu Asp Leu Asp Ser Gln Val Gly Val Ile Asp Phe Ser Leu
                 165                 170                 175    
 Tyr Leu Lys Asp Val Gln Asp Leu Asp Gly Gly Lys Glu His Glu Arg
             180                 185                 190        
 Ile Thr Asp Val Leu Asp Gln Lys Asn Tyr Val Glu Glu Leu Asn Arg
         195                 200                 205            
 His Leu Ser Cys Thr Val Gly Asp Leu Gln Thr Lys Ile Asp Gly Leu
     210                 215                 220                
 Glu Lys Thr Asn Ser Lys Leu Gln Glu Glu Leu Ser Ala Ala Thr Asp
 225                 230                 235                 240
 Arg Ile Cys Ser Leu Gln Glu Glu Gln Gln Gln Leu Arg Glu Gln Asn
                 245                 250                 255    
 Glu Leu Ile Arg Glu Arg Ser Glu Lys Ser Val Glu Ile Thr Lys Gln
             260                 265                 270        
 Asp Thr Lys Val Glu Leu Glu Thr Tyr Lys Gln Thr Arg Gln Gly Leu
         275                 280                 285            
 Asp Glu Met Tyr Ser Asp Val Trp Lys Gln Leu Lys Glu Glu Lys Lys
     290                 295                 300                
 Val Arg Leu Glu Leu Glu Lys Glu Leu Glu Leu Gln Ile Gly Met Lys
 305                 310                 315                 320
 Thr Glu Met Glu Ile Ala Met Lys Leu Leu Glu Lys Asp Thr His Glu
                 325                 330                 335    
 Lys Gln Asp Thr Leu Val Ala Leu Arg Gln Gln Leu Glu Glu Val Lys
             340                 345                 350        
 Ala Ile Asn Leu Gln Met Phe His Lys Ala Gln Asn Ala Glu Ser Ser
         355                 360                 365            
 Leu Gln Gln Lys Asn Glu Ala Ile Thr Ser Phe Glu Gly Lys Thr Asn
     370                 375                 380                
 Gln Val Met Ser Ser Met Lys Gln Met Glu Glu Arg Leu Gln His Ser
 385                 390                 395                 400
 Glu Arg Ala Arg Gln Gly Ala Glu Glu Arg Ser His Lys Leu Gln Gln
                 405                 410                 415    
 Glu Leu Gly Gly Arg Ile Gly Ala Leu Gln Leu Gln Leu Ser Gln Leu
             420                 425                 430        
 His Glu Gln Cys Ser Ser Leu Glu Lys Glu Leu Lys Ser Glu Lys Glu
         435                 440                 445            
 Gln Arg Gln Ala Leu Gln Arg Glu Leu Gln His Glu Lys Asp Thr Ser
     450                 455                 460                
 Ser Leu Leu Arg Met Glu Leu Gln Gln Val Glu Gly Leu Lys Lys Glu
 465                 470                 475                 480
 Leu Arg Glu Leu Gln Asp Glu Lys Ala Glu Leu Gln Lys Ile Cys Glu
                 485                 490                 495    
 Glu Gln Glu Gln Ala Leu Gln Glu Met Gly Leu His Leu Ser Gln Ser
             500                 505                 510        
 Lys Leu Lys Met Glu Asp Ile Lys Glu Val Asn Gln Ala Leu Lys Gly
         515                 520                 525            
 His Ala Trp Leu Lys Asp Asp Glu Ala Thr His Cys Arg Gln Cys Glu
     530                 535                 540                
 Lys Glu Phe Ser Ile Ser Arg Arg Lys His His Cys Arg Asn Cys Gly
 545                 550                 555                 560
 His Ile Phe Cys Asn Thr Cys Ser Ser Asn Glu Leu Pro Cys Pro Pro
                 565                 570                 575    
 Thr Pro Ser Arg Cys Glu Cys Ala Thr Ala Ala Thr Pro Cys Ser Cys
             580                 585                 590        
 Ser Ala Ala Pro Pro Arg Pro Pro Glu Arg Pro Ser Ser Gly Ala Gln
         595                 600                 605            
 Pro His Gly Gln Cys Gln Thr Leu Trp Val Ser Arg Gly Leu Gly Asn
     610                 615                 620                
 Val Phe Phe Pro Lys Ser Ile Lys Gly Lys Asn Gln Ile Ser Cys Pro
 625                 630                 635                 640
 Val Thr Gly Thr Pro Glu Asp Ser Val Pro Glu Pro Ala Ala Leu Thr
                 645                 650                 655    
 Phe Leu
        



      <210> 948
      <211> 312
      <212> PRT
      <213> Homo sapiens


      <400> 948
 Met Gly Leu Arg Gly Val Leu His Leu Leu Pro Thr Thr Asp Ala Val
   1               5                  10                  15    
 Pro Cys Pro Arg Ile Ser Met Ile Pro Thr His Trp Phe Ile Leu Leu
              20                  25                  30        
 Phe Val Pro Val Leu Phe Gly Leu Pro Thr Cys Leu His His Leu Pro
          35                  40                  45            
 Asn Phe Pro Ile Arg Pro Pro Ser Pro Ile Ser Val Arg Tyr Leu Cys
      50                  55                  60                
 Met Pro Cys Met Glu Val Pro Met Ala His Leu Met Ala Ala Arg Glu
  65                  70                  75                  80
 Gln Ser Gly Asn Pro Pro Gln Gln Leu Val Thr Glu Ala Glu Leu Met
                  85                  90                  95    
 Ser Ser Ser Gly Ser Pro Phe Arg Asp Gln Met Leu Ser Lys Cys Leu
             100                 105                 110        
 Glu Ser Glu Trp Gln Ala Phe Arg Arg Ile Glu Arg Val Arg Gln Phe
         115                 120                 125            
 Gly Ala Glu Ile His Thr Leu Leu Leu Tyr Cys Glu Ile Leu Val Arg
     130                 135                 140                
 Ser Phe Cys Val Ser Leu Cys Val Arg Tyr Leu His Ile Tyr Tyr Leu
 145                 150                 155                 160
 Thr His Ser Ser His Gln Leu Gly Asp Leu Lys Ile Val Ser Ile Phe
                 165                 170                 175    
 Pro Leu Arg Lys Gln Lys Phe Arg Glu Cys Glu Lys Pro Met Glu Gly
             180                 185                 190        
 Lys Gln Cys Ser Ser Gln Asp Ile Met Gly Ser Gln Gly Asp Ala Val
         195                 200                 205            
 Ser Arg Glu Ala Glu Ala Ala Ala Gln Leu Gln Glu Glu Val Arg Val
     210                 215                 220                
 Glu Ser Thr Gln Ser Ala Phe Pro Gly Trp Glu Leu Pro Glu Tyr Leu
 225                 230                 235                 240
 Thr Leu Gly Thr Ala Gly Val Ala Pro Met Ala Leu Leu Ser Ala Asp
                 245                 250                 255    
 Gly Leu His Ser Phe Pro Ser Glu Ala Phe Leu Glu Gly Val Leu Ser
             260                 265                 270        
 Ser Lys Ala Leu Trp Ser Pro Leu Arg Thr Lys Gly Asn Gln Leu Asn
         275                 280                 285            
 Arg Ala Phe His Val Thr Thr Lys Asn Asp Leu Ala Gln Thr Ser Arg
     290                 295                 300                
 Gln Ala Ser Val Glu Pro Gly Lys
 305                 310        



      <210> 949
      <211> 155
      <212> PRT
      <213> Homo sapiens


      <400> 949
 Met Lys Gly Leu Arg Ser Leu Ala Ala Thr Thr Leu Ala Leu Phe Leu
   1               5                  10                  15    
 Val Phe Val Phe Leu Gly Asn Ser Ser Cys Ala Pro Gln Arg Leu Leu
              20                  25                  30        
 Glu Arg Arg Asn Trp Thr Pro Gln Ala Met Leu Tyr Leu Lys Gly Ala
          35                  40                  45            
 Gln Gly Arg Arg Phe Ile Ser Asp Gln Ser Arg Arg Lys Asp Leu Ser
      50                  55                  60                
 Asp Arg Pro Leu Pro Glu Arg Arg Ser Pro Asn Pro Gln Leu Leu Thr
  65                  70                  75                  80
 Ile Pro Glu Ala Ala Thr Ile Leu Leu Ala Ser Leu Gln Ile Val Ser
                  85                  90                  95    
 Ser Trp Arg Lys Asp Leu Ser Asp Arg Pro Leu Pro Glu Arg Arg Ser
             100                 105                 110        
 Pro Asn Pro Gln Leu Leu Thr Ile Pro Glu Ala Ala Thr Ile Leu Leu
         115                 120                 125            
 Ala Ser Leu Gln Lys Ser Pro Glu Asp Glu Glu Lys Asn Phe Asp Gln
     130                 135                 140                
 Thr Arg Phe Leu Glu Asp Ser Leu Leu Asn Trp
 145                 150                 155



      <210> 950
      <211> 241
      <212> PRT
      <213> Homo sapiens


      <400> 950
 Met His Glu Glu Glu Ile Tyr Thr Ser Leu Gln Trp Asp Ser Pro Ala
   1               5                  10                  15    
 Pro Asp Thr Tyr Gln Lys Cys Leu Ser Ser Asn Lys Cys Ser Gly Ala
              20                  25                  30        
 Cys Cys Leu Val Met Val Ile Ser Cys Val Phe Cys Met Gly Leu Leu
          35                  40                  45            
 Thr Ala Ser Ile Phe Leu Gly Val Lys Leu Leu Gln Val Ser Thr Ile
      50                  55                  60                
 Ala Met Gln Gln Gln Glu Lys Leu Ile Gln Gln Glu Arg Ala Leu Leu
  65                  70                  75                  80
 Asn Phe Thr Glu Trp Lys Arg Ser Cys Ala Leu Gln Met Lys Tyr Cys
                  85                  90                  95    
 Gln Ala Phe Met Gln Asn Ser Leu Ser Ser Ala His Asn Ser Ser Pro
             100                 105                 110        
 Cys Pro Asn Asn Trp Ile Gln Asn Arg Glu Ser Cys Tyr Tyr Val Ser
         115                 120                 125            
 Glu Ile Trp Ser Ile Trp His Thr Ser Gln Glu Asn Cys Leu Lys Glu
     130                 135                 140                
 Gly Ser Thr Leu Leu Gln Ile Glu Ser Lys Glu Glu Met Asp Phe Ile
 145                 150                 155                 160
 Thr Gly Ser Leu Arg Lys Ile Lys Gly Ser Tyr Asp Tyr Trp Val Gly
                 165                 170                 175    
 Leu Ser Gln Asp Gly His Ser Gly Arg Trp Leu Trp Gln Asp Gly Ser
             180                 185                 190        
 Ser Pro Ser Pro Gly Leu Leu Pro Ala Glu Arg Ser Gln Ser Ala Asn
         195                 200                 205            
 Gln Val Cys Gly Tyr Val Lys Ser Asn Ser Leu Leu Ser Ser Asn Cys
     210                 215                 220                
 Ser Thr Trp Lys Tyr Phe Ile Cys Glu Lys Tyr Ala Leu Arg Ser Ser
 225                 230                 235                 240
 Val
    



      <210> 951
      <211> 281
      <212> PRT
      <213> Homo sapiens


      <400> 951
 Met Gly Ser Leu Leu Ala Ser Ser Leu Ser Trp Thr Ala Pro Pro Trp
   1               5                  10                  15    
 Leu Ala Lys Ala Ala Ser Ala Thr Gly Leu Gly Ala Cys Thr Ala Ile
              20                  25                  30        
 Asp Thr Thr Arg Tyr Ser Asn Trp Gly Gly Ser Ser Glu Glu Val Pro
          35                  40                  45            
 Gly Gly Pro Trp Gly Arg Trp Val His Trp Ser Arg Arg Pro Leu Phe
      50                  55                  60                
 Leu Ala Leu Ala Val Leu Val Thr Thr Val Leu Trp Ala Val Ile Leu
  65                  70                  75                  80
 Ser Ile Leu Leu Ser Lys Ala Ser Thr Glu Arg Ala Ala Leu Leu Asp
                  85                  90                  95    
 Gly His Asp Leu Leu Arg Thr Asn Ala Ser Lys Gln Thr Ala Ala Leu
             100                 105                 110        
 Gly Ala Leu Lys Glu Glu Val Gly Asp Cys His Ser Cys Cys Ser Gly
         115                 120                 125            
 Thr Gln Ala Leu Leu Gln Thr Thr Arg Ala Glu Leu Gly Glu Ala Gln
     130                 135                 140                
 Ala Lys Leu Met Glu Gln Glu Arg Ala Leu Arg Glu Leu Arg Glu Arg
 145                 150                 155                 160
 Val Thr His Gly Leu Ala Glu Ala Gly Arg Asp Arg Glu Asp Val Ser
                 165                 170                 175    
 Thr Glu Leu Tyr Arg Ala Leu Glu Ala Val Arg Leu Gln Asn Ser Glu
             180                 185                 190        
 Gly Ser Cys Glu Pro Cys Pro Thr Ser Trp Leu Pro Phe Gly Gly Ser
         195                 200                 205            
 Cys Tyr Tyr Phe Ser Val Pro Lys Thr Thr Trp Ala Glu Ala Gln Gly
     210                 215                 220                
 His Cys Ala Asp Ala Ser Ala His Leu Ala Ile Val Gly Gly Leu Gly
 225                 230                 235                 240
 Glu Gln Asp Phe Leu Ser Arg Asp Thr Ser Ala Arg Glu Tyr Trp Ile
                 245                 250                 255    
 Gly Arg Arg Ala Val Gln His Leu Arg Lys Val Gln Gly Tyr Ser Trp
             260                 265                 270        
 Val Asp Gly Val Pro Leu Ser Phe Arg
         275                 280    



      <210> 952
      <211> 1541
      <212> PRT
      <213> Homo sapiens


      <400> 952
 Met Gly Cys Lys Gly Asp Ala Ser Gly Ala Cys Ala Ala Gly Val Cys
   1               5                  10                  15    
 Tyr Lys Met Gly Val Leu Val Val Leu Thr Val Leu Trp Leu Phe Ser
              20                  25                  30        
 Ser Val Lys Ala Asp Ser Lys Ala Ile Thr Thr Ser Leu Thr Thr Lys
          35                  40                  45            
 Trp Phe Ser Thr Pro Leu Leu Leu Glu Ala Ser Glu Phe Leu Ala Glu
      50                  55                  60                
 Asp Ser Gln Glu Lys Phe Trp Asn Phe Val Glu Ala Ser Gln Asn Ile
  65                  70                  75                  80
 Gly Ser Ser Asp His Asp Gly Thr Asp Tyr Ser Tyr Tyr His Ala Ile
                  85                  90                  95    
 Leu Glu Ala Ala Phe Gln Phe Leu Ser Pro Leu Gln Gln Asn Leu Phe
             100                 105                 110        
 Lys Phe Cys Leu Ser Leu Arg Ser Tyr Ser Ala Thr Ile Gln Ala Phe
         115                 120                 125            
 Gln Gln Ile Ala Ala Asp Glu Pro Pro Pro Glu Gly Cys Asn Ser Phe
     130                 135                 140                
 Phe Ser Val His Gly Lys Lys Thr Cys Glu Ser Asp Thr Leu Glu Ala
 145                 150                 155                 160
 Leu Leu Leu Thr Ala Ser Glu Arg Pro Lys Pro Leu Leu Phe Lys Gly
                 165                 170                 175    
 Asp His Arg Tyr Pro Ser Ser Asn Pro Glu Ser Pro Val Val Ile Phe
             180                 185                 190        
 Tyr Ser Glu Ile Gly Ser Glu Glu Phe Ser Asn Phe His Arg Gln Leu
         195                 200                 205            
 Ile Ser Lys Ser Asn Ala Gly Lys Ile Asn Tyr Val Phe Arg His Tyr
     210                 215                 220                
 Ile Phe Asn Pro Arg Lys Glu Pro Val Tyr Leu Ser Gly Tyr Gly Val
 225                 230                 235                 240
 Glu Leu Ala Ile Lys Ser Thr Glu Tyr Lys Ala Lys Asp Asp Thr Gln
                 245                 250                 255    
 Val Lys Gly Thr Glu Val Asn Thr Thr Val Ile Gly Glu Asn Asp Pro
             260                 265                 270        
 Ile Asp Glu Val Gln Gly Phe Leu Phe Gly Lys Leu Arg Asp Leu His
         275                 280                 285            
 Pro Asp Leu Glu Gly Gln Leu Lys Glu Leu Arg Lys His Leu Val Glu
     290                 295                 300                
 Ser Thr Asn Glu Met Ala Pro Leu Lys Val Trp Gln Leu Gln Asp Leu
 305                 310                 315                 320
 Ser Phe Gln Thr Ala Ala Arg Ile Leu Ala Ser Pro Val Glu Leu Ala
                 325                 330                 335    
 Leu Val Val Met Lys Asp Leu Ser Gln Asn Phe Pro Thr Lys Ala Arg
             340                 345                 350        
 Ala Ile Thr Lys Thr Ala Val Ser Ser Glu Leu Arg Thr Glu Val Glu
         355                 360                 365            
 Glu Asn His Lys Tyr Phe Lys Gly Thr Leu Gly Leu Gln Pro Gly Asp
     370                 375                 380                
 Ser Ala Leu Phe Ile Asn Gly Leu His Met Asp Leu Asp Thr Gln Asp
 385                 390                 395                 400
 Ile Phe Ser Leu Phe Asp Val Leu Arg Asn Glu Ala Arg Val Met Glu
                 405                 410                 415    
 Gly Leu His Arg Leu Gly Ile Glu Gly Leu Ser Leu His Asn Val Leu
             420                 425                 430        
 Lys Leu Asn Ile Gln Pro Ser Glu Ala Asp Tyr Ala Val Asp Ile Arg
         435                 440                 445            
 Ser Pro Ala Ile Ser Trp Val Asn Asn Leu Glu Val Asp Ser Arg Tyr
     450                 455                 460                
 Asn Ser Trp Pro Ser Ser Leu Gln Glu Leu Leu Arg Pro Thr Phe Pro
 465                 470                 475                 480
 Gly Val Ile Arg Gln Ile Arg Lys Asn Leu His Asn Met Val Phe Ile
                 485                 490                 495    
 Val Asp Pro Ala His Glu Thr Thr Ala Glu Leu Met Asn Thr Ala Glu
             500                 505                 510        
 Met Phe Leu Ser Asn His Ile Pro Leu Arg Ile Gly Phe Ile Phe Val
         515                 520                 525            
 Val Asn Asp Ser Glu Asp Val Asp Gly Met Gln Asp Ala Gly Val Ala
     530                 535                 540                
 Val Leu Arg Ala Tyr Asn Tyr Val Ala Gln Glu Val Asp Asp Tyr His
 545                 550                 555                 560
 Ala Phe Gln Thr Leu Thr His Ile Tyr Asn Lys Val Arg Thr Gly Glu
                 565                 570                 575    
 Lys Val Lys Val Glu His Val Val Ser Val Leu Glu Lys Lys Tyr Pro
             580                 585                 590        
 Tyr Val Glu Val Asn Ser Ile Leu Gly Ile Asp Ser Ala Tyr Asp Arg
         595                 600                 605            
 Asn Arg Lys Glu Ala Arg Gly Tyr Tyr Glu Gln Thr Gly Val Gly Pro
     610                 615                 620                
 Leu Pro Val Val Leu Phe Asn Gly Met Pro Phe Glu Arg Glu Gln Leu
 625                 630                 635                 640
 Asp Pro Asp Glu Leu Glu Thr Ile Thr Met His Lys Ile Leu Glu Thr
                 645                 650                 655    
 Thr Thr Phe Phe Gln Arg Ala Val Tyr Leu Gly Glu Leu Pro His Asp
             660                 665                 670        
 Gln Asp Ala Val Glu Tyr Ile Met Asn Gln Pro Asn Val Val Pro Arg
         675                 680                 685            
 Ile Asn Ser Arg Ile Leu Thr Ala Glu Arg Asp Tyr Leu Asp Leu Thr
     690                 695                 700                
 Ala Ser Asn Asn Phe Phe Val Asp Asp Tyr Ala Arg Phe Thr Ile Leu
 705                 710                 715                 720
 Asp Ser Gln Gly Lys Thr Ala Ala Val Ala Asn Ser Met Asn Tyr Leu
                 725                 730                 735    
 Thr Lys Lys Asp Asp Ser Phe Ile Arg Pro Val Thr Phe Trp Ile Val
             740                 745                 750        
 Gly Asp Phe Asp Ser Pro Ser Gly Arg Gln Leu Leu Tyr Asp Ala Ile
         755                 760                 765            
 Lys His Gln Lys Ser Ser Asn Asn Val Arg Ile Ser Met Ile Asn Asn
     770                 775                 780                
 Pro Ala Lys Glu Ile Ser Tyr Glu Asn Thr Gln Ile Ser Arg Ala Ile
 785                 790                 795                 800
 Trp Ala Ala Leu Gln Thr Gln Thr Ser Asn Ala Ala Lys Asn Phe Ile
                 805                 810                 815    
 Thr Lys Met Ala Lys Glu Gly Ala Ala Glu Ala Leu Ala Ala Gly Ala
             820                 825                 830        
 Asp Ile Ala Glu Phe Ser Val Gly Gly Met Asp Phe Ser Leu Phe Lys
         835                 840                 845            
 Glu Val Phe Glu Ser Ser Lys Met Asp Phe Ile Leu Ser His Ala Val
     850                 855                 860                
 Tyr Cys Arg Asp Val Leu Lys Leu Lys Lys Gly Gln Arg Ala Val Ile
 865                 870                 875                 880
 Ser Asn Gly Arg Ile Ile Gly Pro Leu Glu Asp Ser Glu Leu Phe Asn
                 885                 890                 895    
 Gln Asp Asp Phe His Leu Leu Glu Asn Ile Ile Leu Lys Thr Ser Gly
             900                 905                 910        
 Gln Lys Ile Lys Ser His Ile Gln Gln Leu Arg Val Glu Glu Asp Val
         915                 920                 925            
 Ala Ser Asp Leu Val Met Lys Val Asp Ala Leu Leu Ser Ala Gln Pro
     930                 935                 940                
 Lys Gly Asp Pro Arg Ile Glu Tyr Gln Phe Phe Glu Asp Arg His Ser
 945                 950                 955                 960
 Ala Ile Lys Leu Arg Pro Lys Glu Gly Glu Thr Tyr Phe Asp Val Val
                 965                 970                 975    
 Ala Val Val Asp Pro Val Thr Arg Glu Ala Gln Arg Leu Ala Pro Leu
             980                 985                 990        
 Leu Leu Val Leu Ala Gln Leu Ile Asn Met Asn Leu Arg Val Phe Met
         995                1000                1005            
 Asn Cys Gln Ser Lys Leu Ser Asp Met Pro Leu Lys Ser Phe Tyr Arg
    1010                1015                1020                
 Tyr Val Leu Glu Pro Glu Ile Ser Phe Thr Ser Asp Asn Ser Phe Ala
1025                1030                1035                1040
 Lys Gly Pro Ile Ala Lys Phe Leu Asp Met Pro Gln Ser Pro Leu Phe
                1045                1050                1055    
 Thr Leu Asn Leu Asn Thr Pro Glu Ser Trp Met Val Glu Ser Val Arg
            1060                1065                1070        
 Thr Pro Tyr Asp Leu Asp Asn Ile Tyr Leu Glu Glu Val Asp Ser Val
        1075                1080                1085            
 Val Ala Ala Glu Tyr Glu Leu Glu Tyr Leu Leu Leu Glu Gly His Cys
    1090                1095                1100                
 Tyr Asp Ile Thr Thr Gly Gln Pro Pro Arg Gly Leu Gln Phe Thr Leu
1105                1110                1115                1120
 Gly Thr Ser Ala Asn Pro Val Ile Val Asp Thr Ile Val Met Ala Asn
                1125                1130                1135    
 Leu Gly Tyr Phe Gln Leu Lys Ala Asn Pro Gly Ala Trp Ile Leu Arg
            1140                1145                1150        
 Leu Arg Lys Gly Arg Ser Glu Asp Ile Tyr Arg Ile Tyr Ser His Asp
        1155                1160                1165            
 Gly Thr Asp Ser Pro Pro Asp Ala Asp Glu Val Val Ile Val Leu Asn
    1170                1175                1180                
 Asn Phe Lys Ser Lys Ile Ile Lys Val Lys Val Gln Lys Lys Ala Asp
1185                1190                1195                1200
 Met Val Asn Glu Asp Leu Leu Ser Asp Gly Thr Ser Glu Asn Glu Ser
                1205                1210                1215    
 Gly Phe Trp Asp Ser Phe Lys Trp Gly Phe Thr Gly Gln Lys Thr Glu
            1220                1225                1230        
 Glu Val Lys Gln Asp Lys Asp Asp Ile Ile Asn Ile Phe Ser Val Ala
        1235                1240                1245            
 Ser Gly His Leu Tyr Glu Arg Phe Leu Arg Ile Met Met Leu Ser Val
    1250                1255                1260                
 Leu Lys Asn Thr Lys Thr Pro Val Lys Phe Trp Phe Leu Lys Asn Tyr
1265                1270                1275                1280
 Leu Ser Pro Thr Phe Lys Glu Phe Ile Pro Tyr Met Ala Asn Glu Tyr
                1285                1290                1295    
 Asn Phe Gln Tyr Glu Leu Val Gln Tyr Lys Trp Pro Arg Trp Leu His
            1300                1305                1310        
 Gln Gln Thr Glu Lys Gln Arg Ile Ile Trp Gly Tyr Lys Ile Leu Phe
        1315                1320                1325            
 Leu Asp Val Leu Phe Pro Leu Val Val Asp Lys Phe Leu Phe Val Asp
    1330                1335                1340                
 Ala Asp Gln Ile Val Arg Thr Asp Leu Lys Glu Leu Arg Asp Phe Asn
1345                1350                1355                1360
 Leu Asp Gly Ala Pro Tyr Gly Tyr Thr Pro Phe Cys Asp Ser Arg Arg
                1365                1370                1375    
 Glu Met Asp Gly Tyr Arg Phe Trp Lys Ser Gly Tyr Trp Ala Ser His
            1380                1385                1390        
 Leu Ala Gly Arg Lys Tyr His Ile Ser Ala Leu Tyr Val Val Asp Leu
        1395                1400                1405            
 Lys Lys Phe Arg Lys Ile Ala Ala Gly Asp Arg Leu Arg Gly Gln Tyr
    1410                1415                1420                
 Gln Gly Leu Ser Gln Asp Pro Asn Ser Leu Ser Asn Leu Asp Gln Asp
1425                1430                1435                1440
 Leu Pro Asn Asn Met Ile His Gln Val Pro Ile Lys Ser Leu Pro Gln
                1445                1450                1455    
 Glu Trp Leu Trp Cys Glu Thr Trp Cys Asp Asp Ala Ser Lys Lys Arg
            1460                1465                1470        
 Ala Lys Thr Ile Asp Leu Cys Asn Asn Pro Met Thr Lys Glu Pro Lys
        1475                1480                1485            
 Leu Glu Ala Ala Val Arg Ile Val Pro Glu Trp Gln Asp Tyr Asp Gln
    1490                1495                1500                
 Glu Ile Lys Gln Leu Gln Ile Arg Phe Gln Lys Glu Lys Glu Thr Gly
1505                1510                1515                1520
 Ala Leu Tyr Lys Glu Lys Thr Lys Glu Pro Ser Arg Glu Gly Pro Gln
                1525                1530                1535    
 Lys Arg Glu Glu Leu
            1540    



      <210> 953
      <211> 239
      <212> PRT
      <213> Homo sapiens


      <400> 953
 Met Gln Arg Gly Ala Leu Ser Pro Val Leu Met Leu Ser Ala Ala Pro
   1               5                  10                  15    
 Glu Pro Pro Pro Arg Pro Pro Pro Ala Leu Ser Pro Pro Gly Ser Gly
              20                  25                  30        
 Pro Gly Ser Gly Ser Arg His Gly Ser Ala Arg Pro Gly Pro Thr Pro
          35                  40                  45            
 Glu Pro Ser Gly Ser Leu Gly Ala Ala Leu Asp Ser Ser Leu Arg Ala
      50                  55                  60                
 Ala Val Ala Phe Lys Ala Glu Gly Gln Arg Cys Tyr Arg Glu Lys Lys
  65                  70                  75                  80
 Phe Arg Glu Ala Ile Gly Lys Tyr His Arg Ala Leu Leu Gln Leu Lys
                  85                  90                  95    
 Ala Ala Gln Gly Ala Arg Pro Ser Gly Leu Pro Ala Pro Ala Pro Gly
             100                 105                 110        
 Pro Thr Ser Ser Pro Gly Pro Ala Arg Leu Ser Glu Glu Gln Arg Arg
         115                 120                 125            
 Leu Val Glu Ser Thr Glu Val Glu Cys Tyr Asp Ser Leu Thr Ala Cys
     130                 135                 140                
 Leu Leu Gln Ser Glu Leu Val Asn Tyr Glu Arg Val Arg Glu Tyr Cys
 145                 150                 155                 160
 Leu Lys Val Leu Glu Lys Gln Gln Gly Asn Phe Lys Ala Thr Tyr Arg
                 165                 170                 175    
 Ala Gly Ile Ala Phe Tyr His Leu Gly Asp Tyr Ala Arg Ala Leu Arg
             180                 185                 190        
 Tyr Leu Gln Glu Ala Arg Ser Arg Glu Pro Thr Asp Thr Asn Val Leu
         195                 200                 205            
 Arg Tyr Ile Gln Leu Thr Gln Leu Lys Met Asn Arg Cys Ser Leu Gln
     210                 215                 220                
 Arg Glu Asp Ser Gly Ala Gly Ser Gln Thr Arg Asp Val Ile Gly
 225                 230                 235                



      <210> 954
      <211> 456
      <212> PRT
      <213> Homo sapiens


      <400> 954
 Met Gln Glu Met Asn Asp Lys Ala Ile Phe Lys Thr Leu Phe Leu Phe
   1               5                  10                  15    
 Phe Pro Gln Ser Leu Val Leu Ile Ser Lys Leu Pro Tyr Ile His Phe
              20                  25                  30        
 Phe His Thr Val Leu Lys Gln Ile Ala Pro Glu Tyr Phe Glu Lys Asn
          35                  40                  45            
 Glu Pro Tyr Leu Glu Ala Ala Cys Asn Asp Val Asp Arg Trp Pro Ala
      50                  55                  60                
 Pro Val Pro Gly Lys Thr Leu His Leu Pro Ile Met Gly Val Val Met
  65                  70                  75                  80
 Lys Val Arg Ile Pro Thr Cys His Asp Lys Pro Gly Thr Thr Gln Ile
                  85                  90                  95    
 Val Gln Leu Thr Gln Gln Val Asp Thr Asn Ile Ser Val Ile Leu Pro
             100                 105                 110        
 Thr Val His Glu Gly Asp Ile Phe Arg Cys Phe Cys Pro Val Phe Leu
         115                 120                 125            
 His Ser Gln Met Leu Trp Glu Leu Val Leu Leu Gly Glu Pro Leu Val
     130                 135                 140                
 Val Met Ala Pro Ser Pro Ser Glu Ser Ser Glu Thr Val Leu Ala Leu
 145                 150                 155                 160
 Val Asn Cys Ile Ser Pro Leu Lys Tyr Phe Ser Asp Phe Arg Pro Tyr
                 165                 170                 175    
 Phe Thr Ile His Asp Ser Glu Phe Lys Glu Tyr Thr Thr Arg Thr Gln
             180                 185                 190        
 Ala Pro Pro Ser Val Ile Leu Gly Val Thr Asn Pro Phe Phe Ala Lys
         195                 200                 205            
 Thr Leu Gln His Trp Pro His Ile Ile Arg Ile Gly Asp Leu Lys Pro
     210                 215                 220                
 Thr Gly Glu Ile Pro Lys Gln Val Lys Val Lys Lys Leu Lys Asn Leu
 225                 230                 235                 240
 Lys Thr Leu Asp Ser Lys Pro Gly Val Tyr Thr Ser Tyr Lys Pro Tyr
                 245                 250                 255    
 Leu Asn Arg Asp Glu Glu Ile Ile Lys Gln Leu Gln Lys Gly Val Gln
             260                 265                 270        
 Gln Lys Arg Pro Ser Glu Ala Gln Ser Val Ile Leu Arg Arg Tyr Phe
         275                 280                 285            
 Leu Glu Leu Thr Gln Ser Phe Ile Ile Pro Leu Glu Arg Tyr Val Ala
     290                 295                 300                
 Ser Leu Met Pro Leu Gln Lys Ser Ile Ser Pro Trp Lys Ser Pro Pro
 305                 310                 315                 320
 Gln Leu Arg Gln Phe Leu Pro Glu Glu Phe Met Lys Thr Leu Glu Lys
                 325                 330                 335    
 Thr Gly Pro Gln Leu Thr Ser Arg Ile Lys Gly Asp Trp Ile Gly Leu
             340                 345                 350        
 Tyr Arg His Phe Leu Lys Ser Pro Asn Phe Asp Gly Trp Phe Lys Thr
         355                 360                 365            
 Arg Arg Lys Glu Met Thr Gln Lys Leu Glu Ala Leu His Leu Glu Ala
     370                 375                 380                
 Leu Cys Glu Glu Asp Leu Leu Leu Trp Ile Gln Lys His Thr Glu Val
 385                 390                 395                 400
 Glu Thr Val Asp Leu Val Leu Lys Leu Lys Asn Lys Leu Leu Gln Ala
                 405                 410                 415    
 Asp Arg Glu His Leu Pro Val Lys Pro Asp Thr Met Glu Lys Leu Arg
             420                 425                 430        
 Thr His Ile Asp Ala Ile Ile Leu Ala Leu Pro Glu Asp Leu Gln Gly
         435                 440                 445            
 Ile Leu Leu Lys Thr Gly Met Thr
     450                 455    



      <210> 955
      <211> 399
      <212> PRT
      <213> Homo sapiens


      <400> 955
 Met Ser Ala Arg Gly Arg Trp Glu Gly Gly Gly Arg Arg Ala Cys Arg
   1               5                  10                  15    
 Gly Ser Leu Gly Leu Ala Arg Ala Gln Gly Ala Glu Arg Val Thr Ser
              20                  25                  30        
 Ser Glu Gln Arg Pro Ala Met Ala Ser Leu Gly Leu Leu Leu Leu Leu
          35                  40                  45            
 Leu Leu Thr Ala Leu Pro Pro Leu Trp Ser Ser Ser Leu Pro Gly Leu
      50                  55                  60                
 Asp Thr Ala Glu Ser Lys Ala Thr Ile Ala Asp Leu Ile Leu Ser Ala
  65                  70                  75                  80
 Leu Glu Arg Ala Thr Val Phe Leu Glu Gln Arg Leu Pro Glu Ile Asn
                  85                  90                  95    
 Leu Asp Gly Met Val Gly Val Arg Val Leu Glu Glu Gln Leu Lys Ser
             100                 105                 110        
 Val Arg Glu Lys Trp Ala Gln Glu Pro Leu Leu Gln Pro Leu Ser Leu
         115                 120                 125            
 Arg Val Gly Met Leu Gly Glu Lys Leu Glu Ala Ala Ile Gln Arg Ser
     130                 135                 140                
 Leu His Tyr Leu Lys Leu Ser Asp Pro Lys Tyr Leu Arg Glu Phe Gln
 145                 150                 155                 160
 Leu Thr Leu Gln Pro Gly Phe Trp Lys Leu Pro His Ala Trp Ile His
                 165                 170                 175    
 Thr Asp Ala Ser Leu Val Tyr Pro Thr Phe Gly Pro Gln Asp Ser Phe
             180                 185                 190        
 Ser Glu Glu Arg Ser Asp Val Cys Leu Val Gln Leu Leu Gly Thr Gly
         195                 200                 205            
 Thr Asp Ser Ser Glu Pro Cys Gly Leu Ser Asp Leu Cys Arg Ser Leu
     210                 215                 220                
 Met Thr Lys Pro Gly Cys Ser Gly Tyr Cys Leu Ser His Gln Leu Leu
 225                 230                 235                 240
 Phe Phe Leu Trp Ala Arg Met Arg Gly Cys Thr Gln Gly Pro Leu Gln
                 245                 250                 255    
 Gln Ser Gln Asp Tyr Ile Asn Leu Phe Cys Ala Asn Met Met Asp Leu
             260                 265                 270        
 Asn Arg Arg Ala Glu Ala Ile Gly Tyr Ala Tyr Pro Thr Arg Asp Ile
         275                 280                 285            
 Phe Met Glu Asn Ile Met Phe Cys Gly Met Gly Gly Phe Ser Asp Phe
     290                 295                 300                
 Tyr Lys Leu Arg Trp Leu Glu Ala Ile Leu Ser Trp Gln Lys Gln Gln
 305                 310                 315                 320
 Glu Gly Cys Phe Gly Glu Pro Asp Ala Glu Asp Glu Glu Ser Ser Lys
                 325                 330                 335    
 Ala Ile Gln Tyr Gln Gln His Phe Ser Arg Arg Val Lys Arg Arg Glu
             340                 345                 350        
 Lys Gln Phe Pro Asp Gly Cys Ser Ser His Asn Thr Ala Thr Ala Val
         355                 360                 365            
 Ala Ala Leu Gly Gly Phe Leu Tyr Ile Leu Ala Glu Tyr Pro Pro Ala
     370                 375                 380                
 Asn Arg Glu Pro His Pro Ser Thr Pro Pro Pro Pro Ser Ser Arg
 385                 390                 395                



      <210> 956
      <211> 311
      <212> PRT
      <213> Homo sapiens


      <400> 956
 Met Asn Phe Trp Arg Tyr Cys Phe Phe Ala Ser Thr Leu Leu Ser Val
   1               5                  10                  15    
 Val Ile Phe Val Arg Phe Tyr Ser Ser Gln Leu Ser Pro Pro Lys Ser
              20                  25                  30        
 Tyr Glu Lys Leu Asn Ser Ser Ser Glu Arg Tyr Phe Arg Lys Thr Ala
          35                  40                  45            
 Cys Asn His Ala Leu Glu Lys Met Pro Val Phe Leu Trp Glu Asn Ile
      50                  55                  60                
 Leu Pro Ser Pro Leu Arg Ser Val Pro Cys Lys Asp Tyr Leu Thr Gln
  65                  70                  75                  80
 Asn His Tyr Ile Thr Ser Pro Leu Ser Glu Glu Glu Ala Ala Phe Pro
                  85                  90                  95    
 Leu Ala Tyr Val Met Val Ile His Lys Asp Phe Asp Thr Phe Glu Arg
             100                 105                 110        
 Leu Phe Arg Ala Ile Tyr Met Pro Gln Asn Val Tyr Cys Val His Val
         115                 120                 125            
 Asp Glu Lys Ala Pro Ala Glu Tyr Lys Glu Ser Val Arg Gln Leu Leu
     130                 135                 140                
 Ser Cys Phe Gln Asn Ala Phe Ile Ala Ser Lys Thr Glu Ser Val Val
 145                 150                 155                 160
 Tyr Ala Gly Ile Ser Arg Leu Gln Ala Asp Leu Asn Cys Leu Lys Asp
                 165                 170                 175    
 Leu Val Ala Ser Glu Val Pro Trp Lys Tyr Val Ile Asn Thr Cys Gly
             180                 185                 190        
 Gln Asp Phe Pro Leu Lys Thr Asn Arg Glu Ile Val Gln His Leu Lys
         195                 200                 205            
 Gly Phe Lys Gly Lys Asn Ile Thr Pro Gly Val Leu Pro Pro Asp His
     210                 215                 220                
 Ala Ile Lys Arg Thr Lys Tyr Val His Gln Glu Arg Thr Asp Lys Gly
 225                 230                 235                 240
 Gly Phe Phe Val Lys Asn Thr Asn Ile Leu Lys Thr Ser Pro Pro His
                 245                 250                 255    
 Gln Leu Thr Ile Tyr Phe Gly Thr Ala Tyr Val Ala Leu Thr Arg Glu
             260                 265                 270        
 Phe Val Asp Phe Val Leu Arg Asp Gln Arg Ala Ile Asp Leu Leu Gln
         275                 280                 285            
 Trp Ser Lys Asp Thr Tyr Ser Pro Asp Glu His Phe Trp Val Thr Leu
     290                 295                 300                
 Asn Arg Val Ser Gly Arg Tyr
 305                 310    



      <210> 957
      <211> 204
      <212> PRT
      <213> Homo sapiens


      <400> 957
 Met Lys Ile Phe Gln Arg Lys Met Arg Tyr Trp Leu Leu Pro Pro Phe
   1               5                  10                  15    
 Leu Ala Ile Val Tyr Phe Cys Thr Ile Val Gln Gly Gln Val Ala Pro
              20                  25                  30        
 Pro Thr Arg Leu Arg Tyr Asn Val Ile Ser His Asp Ser Ile Gln Ile
          35                  40                  45            
 Ser Trp Lys Ala Pro Arg Gly Lys Phe Gly Gly Tyr Lys Leu Leu Val
      50                  55                  60                
 Thr Pro Thr Ser Gly Gly Lys Thr Asn Gln Leu Asn Leu Gln Asn Thr
  65                  70                  75                  80
 Ala Thr Lys Ala Ile Ile Gln Gly Leu Met Pro Asp Gln Asn Tyr Thr
                  85                  90                  95    
 Val Gln Ile Ile Ala Tyr Asn Lys Asp Lys Glu Ser Lys Pro Ala Gln
             100                 105                 110        
 Gly Gln Phe Arg Ile Lys Asp Leu Glu Lys Lys Lys Asp Pro Lys Pro
         115                 120                 125            
 Arg Val Lys Val Val Asp Arg Gly Asn Gly Ser Arg Pro Ser Ser Pro
     130                 135                 140                
 Glu Glu Val Asn Leu Ala Val Glu Ser Arg Asn Ala Asp Ile Val Asp
 145                 150                 155                 160
 Arg Arg Arg Cys Thr Glu Asn Trp Arg Ile Pro Arg Thr Val Arg Gln
                 165                 170                 175    
 Leu Leu Gly Ala Asp Pro Gly Gly His Ala Ile Leu Glu Val Gly Arg
             180                 185                 190        
 His Glu Arg Arg Pro His Gly Ser Leu Arg Gln Thr
         195                 200                



      <210> 958
      <211> 490
      <212> PRT
      <213> Homo sapiens


      <400> 958
 Met His Ser Phe Pro Pro Leu Leu Leu Leu Leu Phe Trp Gly Val Val
   1               5                  10                  15    
 Ser His Ser Phe Pro Ala Thr Leu Glu Thr His Arg Ala Arg Cys Gly
              20                  25                  30        
 Leu Ser Pro Glu Thr Ala Pro Ser Thr Gln Asn Val Ser Ser His Ala
          35                  40                  45            
 Tyr Ala Leu Phe Ser Gln Leu Glu Lys Tyr Leu Glu Lys Tyr Tyr Asn
      50                  55                  60                
 Leu Lys Asn Asp Gly Arg Gln Val Glu Lys Arg Arg Asn Ser Gly Pro
  65                  70                  75                  80
 Val Val Glu Lys Leu Lys Gln Met Gln Glu Phe Phe Gly Leu Lys Val
                  85                  90                  95    
 Thr Gly Lys Pro Asp Ala Glu Thr Leu Lys Val Met Lys Gln Pro Arg
             100                 105                 110        
 Cys Gly Val Pro Asp Val Ala Gln Phe Val Leu Thr Glu Gly Asn Pro
         115                 120                 125            
 Arg Trp Glu Gln Thr His Leu Thr Tyr Arg Ile Glu Asn Tyr Thr Pro
     130                 135                 140                
 Asp Leu Pro Arg Ala Asp Val Asp His Ala Ile Glu Lys Ala Phe Gln
 145                 150                 155                 160
 Leu Trp Ser Asn Val Thr Pro Leu Thr Phe Thr Lys Val Ser Glu Gly
                 165                 170                 175    
 Gln Ala Asp Ile Met Ile Ser Phe Val Arg Gly Asp His Arg Asp Asn
             180                 185                 190        
 Ser Pro Phe Asp Gly Pro Gly Gly Asn Leu Ala His Ala Phe Gln Pro
         195                 200                 205            
 Gly Pro Gly Ile Gly Gly Asp Ala His Phe Asp Glu Asp Glu Arg Trp
     210                 215                 220                
 Thr Asn Asn Phe Arg Glu Tyr Asn Leu His Arg Val Ala Ala His Glu
 225                 230                 235                 240
 Leu Gly His Ser Leu Gly Leu Ser His Ser Thr Asp Ile Gly Ala Leu
                 245                 250                 255    
 Met Tyr Pro Ser Tyr Thr Phe Ser Gly Asp Val Gln Leu Ala Gln Asp
             260                 265                 270        
 Asp Ile Asp Gly Ile Gln Ala Ile Tyr Gly Arg Ser Gln Asn Pro Val
         275                 280                 285            
 Gln Pro Ile Gly Pro Gln Thr Pro Lys Ala Cys Asp Ser Lys Leu Thr
     290                 295                 300                
 Phe Asp Ala Ile Thr Thr Ile Arg Gly Glu Val Met Phe Phe Lys Asp
 305                 310                 315                 320
 Arg Phe Tyr Met Arg Thr Asn Pro Phe Tyr Pro Glu Val Glu Leu Asn
                 325                 330                 335    
 Phe Ile Ser Val Phe Trp Pro Gln Leu Pro Asn Gly Leu Glu Ala Ala
             340                 345                 350        
 Tyr Glu Phe Ala Asp Arg Asp Glu Val Arg Phe Phe Lys Gly Asn Lys
         355                 360                 365            
 Tyr Trp Ala Val Gln Gly Gln Asn Val Leu His Gly Tyr Pro Lys Asp
     370                 375                 380                
 Ile Tyr Ser Ser Phe Gly Phe Pro Arg Thr Val Lys His Ile Asp Ala
 385                 390                 395                 400
 Ala Leu Ser Glu Glu Asn Thr Gly Lys Thr Tyr Phe Phe Val Ala Asn
                 405                 410                 415    
 Lys Tyr Trp Arg Tyr Asp Glu Tyr Lys Arg Ser Met Asp Pro Gly Tyr
             420                 425                 430        
 Pro Lys Met Ile Ala His Asp Phe Pro Gly Ile Gly His Lys Val Asp
         435                 440                 445            
 Ala Val Phe Met Lys Asp Gly Phe Phe Tyr Phe Phe His Gly Thr Arg
     450                 455                 460                
 Gln Tyr Lys Phe Asp Pro Lys Thr Lys Arg Ile Leu Thr Leu Gln Lys
 465                 470                 475                 480
 Ala Asn Ser Trp Phe Asn Cys Arg Lys Asn
                 485                 490



      <210> 959
      <211> 202
      <212> PRT
      <213> Homo sapiens


      <400> 959
 Met Arg Val Gly Arg Arg Pro Lys Ala Gln Arg Val Gln Gly Gln Asn
   1               5                  10                  15    
 Gly Asn His Ser Ser Asp Ser Glu Gly Ser Phe Ser Leu Leu Cys Leu
              20                  25                  30        
 Gln Leu Phe Ser Lys Phe Ala Val Val Ser Ile Leu Leu Leu Leu Leu
          35                  40                  45            
 Leu Leu Phe Asn Thr Ser Lys Lys Lys Leu Met Thr Phe Ser Leu Asp
      50                  55                  60                
 Ser Leu Leu Ser Pro Ile Ser Ile Pro Thr Ala Leu Leu Phe Gly Ser
  65                  70                  75                  80
 Pro Pro Pro Pro Pro Ser His Arg Gly Tyr Gly Val Gly Ser Ala Pro
                  85                  90                  95    
 Leu Lys Glu Lys Gln Met Lys Glu Leu Val Pro Pro Arg Arg Glu Cys
             100                 105                 110        
 Thr Val Gln Gly Gln Pro Trp Gln Gly Pro Ser Leu Pro Gly Pro Ala
         115                 120                 125            
 Glu Leu Gly His Arg Pro Gly Thr Arg Leu Gly Val Glu Cys Asp Gly
     130                 135                 140                
 Glu Trp Cys Pro Arg Ser Cys Phe Trp Glu Leu Leu Gly Pro Pro Tyr
 145                 150                 155                 160
 Leu Lys Cys Ser Gln Pro Ser Pro Ile Pro Pro Leu Asp Gly Thr Gln
                 165                 170                 175    
 Thr Ser Ala Glu Arg Gly Arg Gly Leu Ala Pro Glu Val Arg Lys Pro
             180                 185                 190        
 Leu Val Asn Leu Asp Leu Ala Cys Phe Arg
         195                 200        



      <210> 960
      <211> 149
      <212> PRT
      <213> Homo sapiens


      <400> 960
 Met Met Gly Glu Gly Trp Ala Ala Ala Leu Gln Pro Arg Val Leu Gly
   1               5                  10                  15    
 Pro Trp Cys Ala Met Ala Thr Leu Ala Thr Phe Pro Gly Ser Ser Val
              20                  25                  30        
 Cys Gly Arg Leu Cys Gln Ala Leu Tyr Val Ser Cys Ile Ser Ser Ala
          35                  40                  45            
 Ser Ser Gln Leu Cys Glu Ala Glu Val Glu Glu Thr Leu Lys Arg Leu
      50                  55                  60                
 Gln Ser Gln Lys Gly Val Gln Gly Ile Ile Val Val Asn Thr Glu Gly
  65                  70                  75                  80
 Ile Pro Ile Lys Ser Thr Met Asp Asn Pro Thr Thr Thr Gln Tyr Ala
                  85                  90                  95    
 Ser Leu Met His Ser Phe Ile Leu Lys Ala Arg Ser Thr Val Arg Asp
             100                 105                 110        
 Ile Asp Pro Gln Asn Asp Leu Thr Phe Leu Arg Ile Arg Ser Lys Lys
         115                 120                 125            
 Asn Glu Leu Met Val Ala Pro Asp Lys Asp Tyr Phe Leu Ile Val Ile
     130                 135                 140                
 Gln Asn Pro Thr Glu
 145                



      <210> 961
      <211> 139
      <212> PRT
      <213> Homo sapiens


      <400> 961
 Met Gln Leu Arg Met Met Cys Ala Ser Leu Phe Ala Ile Thr Ser Gly
   1               5                  10                  15    
 Ser Gln His Asp Leu Arg Trp Ala Leu Phe Cys Ser Cys Ser Phe Thr
              20                  25                  30        
 Val Cys His Pro Phe Ser Met Ala Val Tyr Phe Val Tyr Gln Ile Lys
          35                  40                  45            
 Arg Asn Gly Met Thr Ala Glu Ala His Ser Val His Leu Trp Thr His
      50                  55                  60                
 Asn Ser Thr Leu Leu Gly Glu Leu Leu Tyr His Pro Gly Ser Lys Asp
  65                  70                  75                  80
 His Leu Cys Lys Ser Glu Gly Lys Leu Cys Arg Ile Lys Ala Glu Val
                  85                  90                  95    
 Ser Arg Asn Phe Gln Tyr Tyr Gly Ala Tyr Ala Ser Leu Leu Arg Leu
             100                 105                 110        
 Met Glu Val Phe Arg Lys Glu Lys Glu Ser Gln Thr Ala Tyr Thr Glu
         115                 120                 125            
 Cys Glu Glu Gly Glu Glu Asn Thr Gln Gly Phe
     130                 135                



      <210> 962
      <211> 308
      <212> PRT
      <213> Homo sapiens


      <400> 962
 Met Ala Ala Val Gly Ala Glu Ala Arg Gly Ala Trp Cys Val Pro Cys
   1               5                  10                  15    
 Leu Val Ser Leu Asp Thr Leu Gln Glu Leu Cys Arg Lys Glu Lys Leu
              20                  25                  30        
 Thr Cys Lys Ser Ile Gly Ile Thr Lys Arg Asn Leu Asn Asn Tyr Glu
          35                  40                  45            
 Val Glu Tyr Leu Cys Asp Tyr Lys Val Val Lys Asp Met Glu Tyr Tyr
      50                  55                  60                
 Leu Val Lys Trp Lys Gly Trp Pro Asp Ser Thr Asn Thr Trp Glu Pro
  65                  70                  75                  80
 Leu Gln Asn Leu Lys Cys Pro Leu Leu Leu Gln Gln Phe Ser Asn Asp
                  85                  90                  95    
 Lys His Asn Tyr Leu Ser Gln Val Lys Lys Gly Lys Ala Ile Thr Pro
             100                 105                 110        
 Lys Asp Asn Asn Lys Thr Leu Lys Pro Ala Ile Ala Glu Tyr Ile Val
         115                 120                 125            
 Lys Lys Ala Lys Gln Arg Ile Ala Leu Gln Arg Trp Gln Asp Glu Leu
     130                 135                 140                
 Asn Arg Arg Lys Asn His Lys Gly Met Ile Phe Val Glu Asn Thr Val
 145                 150                 155                 160
 Asp Leu Glu Gly Pro Pro Ser Asp Phe Tyr Tyr Ile Asn Glu Tyr Lys
                 165                 170                 175    
 Pro Ala Pro Gly Ile Ser Leu Val Asn Glu Ala Thr Phe Gly Cys Ser
             180                 185                 190        
 Cys Thr Asp Cys Phe Phe Gln Lys Cys Cys Pro Ala Glu Ala Gly Val
         195                 200                 205            
 Leu Leu Ala Tyr Asn Lys Asn Gln Gln Ile Lys Ile Pro Pro Gly Thr
     210                 215                 220                
 Pro Ile Tyr Glu Cys Asn Ser Arg Cys Gln Cys Gly Pro Asp Cys Pro
 225                 230                 235                 240
 Asn Arg Ile Val Gln Lys Gly Thr Gln Tyr Ser Leu Cys Ile Phe Arg
                 245                 250                 255    
 Thr Ser Asn Gly Arg Gly Trp Gly Val Lys Thr Leu Val Lys Ile Lys
             260                 265                 270        
 Arg Met Ser Phe Val Met Glu Tyr Val Gly Glu Val Cys Phe Ile Cys
         275                 280                 285            
 His Val Val Asn Asp Gly His Ala Gly Leu Tyr Phe Trp Lys Ile Thr
     290                 295                 300                
 Phe Leu Ser Leu
 305            



      <210> 963
      <211> 98
      <212> PRT
      <213> Homo sapiens


      <400> 963
 Met Ala Val Val Leu Met Lys Thr Thr Gly Leu Val Gly Leu Ala Val
   1               5                  10                  15    
 Cys Asn Thr Pro Asn Glu Arg Leu Arg Ile Leu Ser Thr Lys Ile Leu
              20                  25                  30        
 Asp Val Leu Glu Glu Ile Pro Lys Asn Ala Ala Tyr Arg Lys Phe Thr
          35                  40                  45            
 Glu Gln Ile Thr Asn Glu Lys Leu Ala Met Val Lys Ala Glu Pro Asp
      50                  55                  60                
 Val Lys Lys Leu Glu Asp Gln Leu Gln Gly Gly Gln Leu Glu Glu Val
  65                  70                  75                  80
 Ile Leu Gln Ala Glu His Glu Leu Asn Leu Ala Arg Gln Trp Lys Trp
                  85                  90                  95    
 Pro Ile
        



      <210> 964
      <211> 324
      <212> PRT
      <213> Homo sapiens


      <400> 964
 Met Leu Leu Ala Leu Ala Leu Leu Leu Ala Phe Leu Pro Pro Ala Ser
   1               5                  10                  15    
 Gln Lys Ser Ser Asn Leu Glu Gly Arg Thr Lys Ser Val Thr Arg Pro
              20                  25                  30        
 Thr Gly Ser Ser Ala Val Ile Thr Cys Asp Leu Pro Val Glu Asn Ala
          35                  40                  45            
 Val Tyr Thr His Trp Tyr Leu His Gln Glu Gly Lys Ala Pro Gln Arg
      50                  55                  60                
 Leu Leu Tyr Tyr Asp Ser Tyr Asn Ser Arg Val Val Leu Glu Ser Gly
  65                  70                  75                  80
 Ile Ser Arg Glu Lys Tyr His Thr Tyr Ala Ser Thr Gly Lys Ser Leu
                  85                  90                  95    
 Lys Phe Ile Leu Glu Asn Leu Ile Glu Arg Asp Ser Gly Val Tyr Tyr
             100                 105                 110        
 Cys Ala Thr Trp Thr Asp Arg Ile Tyr Tyr Lys Lys Leu Phe Gly Ser
         115                 120                 125            
 Gly Thr Thr Leu Val Val Thr Asp Lys Gln Leu Asp Ala Asp Val Ser
     130                 135                 140                
 Pro Lys Pro Thr Ile Phe Leu Pro Ser Ile Ala Glu Thr Lys Leu Gln
 145                 150                 155                 160
 Lys Ala Gly Thr Tyr Leu Cys Leu Leu Glu Lys Phe Phe Pro Asp Ile
                 165                 170                 175    
 Ile Lys Ile His Trp Gln Glu Lys Lys Ser Asn Thr Ile Leu Gly Ser
             180                 185                 190        
 Gln Glu Gly Asn Thr Met Lys Thr Asn Asp Thr Tyr Met Lys Phe Ser
         195                 200                 205            
 Trp Leu Thr Val Pro Glu Glu Ser Leu Asp Lys Glu His Arg Cys Ile
     210                 215                 220                
 Val Arg His Glu Asn Asn Lys Asn Gly Ile Asp Gln Glu Ile Ile Phe
 225                 230                 235                 240
 Pro Pro Ile Lys Thr Asp Val Thr Thr Val Asp Pro Lys Asp Ser Tyr
                 245                 250                 255    
 Ser Lys Asp Ala Asn Asp Val Ile Thr Met Asp Pro Lys Asp Asn Trp
             260                 265                 270        
 Ser Lys Asp Ala Ile Asp Thr Leu Leu Leu Gln Leu Thr Asn Thr Ser
         275                 280                 285            
 Ala Tyr Tyr Met Tyr Leu Leu Leu Leu Leu Lys Ser Gly Val Tyr Phe
     290                 295                 300                
 Ala Ile Ile Thr Cys Cys Leu Leu Arg Arg Thr Ala Phe Cys Cys Asn
 305                 310                 315                 320
 Gly Glu Lys Ser
                



      <210> 965
      <211> 113
      <212> PRT
      <213> Homo sapiens


      <400> 965
 Met Asn Glu Thr Asn Lys Thr Leu Val Gly Pro Ser Glu Leu Pro Thr
   1               5                  10                  15    
 Ala Ser Ala Val Ala Pro Gly Pro Ser Thr Gly Ala Arg Ala Leu Ala
              20                  25                  30        
 Val Leu Val Arg Phe Val Leu Gly Ala Val Val Leu Ser Leu Leu Ile
          35                  40                  45            
 Ala Leu Ala Ala Lys Cys His Leu Cys Arg Arg Tyr His Ala Ser Tyr
      50                  55                  60                
 Arg His Arg Pro Leu Pro Glu Thr Gly Arg Gly Gly Arg Pro Gln Val
  65                  70                  75                  80
 Ala Glu Asp Glu Asp Asp Asp Gly Phe Ile Glu Asp Asn Tyr Ile Gln
                  85                  90                  95    
 Pro Gly Thr Gly Glu Leu Gly Thr Glu Gly Ser Arg Asp His Phe Ser
             100                 105                 110        
 Leu
    



      <210> 966
      <211> 633
      <212> PRT
      <213> Homo sapiens


      <400> 966
 Met Asp Ser Thr Thr Cys Gln Thr Ile Asn Gln Gly Tyr Gly Leu Asn
   1               5                  10                  15    
 Met Arg Cys Leu Ala Ala Arg Val Asn Tyr Lys Thr Leu Ile Ile Ile
              20                  25                  30        
 Cys Ala Leu Phe Thr Leu Val Thr Val Leu Leu Trp Asn Lys Cys Ser
          35                  40                  45            
 Ser Asp Lys Ala Ile Gln Phe Pro Arg Arg Ser Ser Ser Gly Phe Arg
      50                  55                  60                
 Val Asp Gly Phe Glu Lys Arg Ala Ala Ala Ser Glu Ser Asn Asn Tyr
  65                  70                  75                  80
 Met Asn His Val Ala Lys Gln Gln Ser Glu Glu Ala Phe Pro Gln Glu
                  85                  90                  95    
 Gln Gln Lys Ala Pro Pro Val Val Gly Gly Phe Asn Ser Asn Val Gly
             100                 105                 110        
 Ser Lys Val Leu Gly Leu Lys Tyr Glu Glu Ile Asp Cys Leu Ile Asn
         115                 120                 125            
 Asp Glu His Thr Ile Lys Gly Arg Arg Glu Gly Asn Glu Val Phe Leu
     130                 135                 140                
 Pro Phe Thr Trp Val Glu Lys Tyr Phe Asp Val Tyr Gly Lys Val Val
 145                 150                 155                 160
 Gln Tyr Asp Gly Tyr Asp Arg Phe Glu Phe Ser His Ser Tyr Ser Lys
                 165                 170                 175    
 Val Tyr Ala Gln Arg Ala Pro Tyr His Pro Asp Gly Val Phe Met Ser
             180                 185                 190        
 Phe Glu Gly Tyr Asn Val Glu Val Arg Asp Arg Val Lys Cys Ile Ser
         195                 200                 205            
 Gly Val Glu Gly Val Pro Leu Ser Thr Gln Trp Gly Pro Gln Gly Tyr
     210                 215                 220                
 Phe Tyr Pro Ile Gln Ile Ala Gln Tyr Gly Leu Ser His Tyr Ser Lys
 225                 230                 235                 240
 Asn Leu Thr Glu Lys Pro Pro His Ile Glu Val Tyr Glu Thr Ala Glu
                 245                 250                 255    
 Asp Arg Asp Lys Asn Lys Pro Asn Asp Trp Thr Val Pro Lys Gly Cys
             260                 265                 270        
 Phe Met Ala Asn Val Ala Asp Lys Ser Arg Phe Thr Asn Val Lys Gln
         275                 280                 285            
 Phe Ile Ala Pro Glu Thr Ser Glu Gly Val Ser Leu Gln Leu Gly Asn
     290                 295                 300                
 Thr Lys Asp Phe Ile Ile Ser Phe Asp Leu Lys Phe Leu Thr Asn Gly
 305                 310                 315                 320
 Ser Val Ser Val Val Leu Glu Thr Thr Glu Lys Asn Gln Leu Phe Thr
                 325                 330                 335    
 Ile His Tyr Val Ser Asn Ala Gln Leu Ile Ala Phe Lys Glu Arg Asp
             340                 345                 350        
 Ile Tyr Tyr Gly Ile Gly Pro Arg Thr Ser Trp Ser Thr Val Thr Arg
         355                 360                 365            
 Asp Leu Val Thr Asp Leu Arg Lys Gly Val Gly Leu Ser Asn Thr Lys
     370                 375                 380                
 Ala Val Lys Pro Thr Lys Ile Met Pro Lys Lys Val Val Arg Leu Ile
 385                 390                 395                 400
 Ala Lys Gly Lys Gly Phe Leu Asp Asn Ile Thr Ile Ser Thr Thr Ala
                 405                 410                 415    
 His Met Ala Ala Phe Phe Ala Ala Ser Asp Trp Leu Val Arg Asn Gln
             420                 425                 430        
 Asp Glu Lys Gly Gly Trp Pro Ile Met Val Thr Arg Lys Leu Gly Glu
         435                 440                 445            
 Gly Phe Lys Ser Leu Glu Pro Gly Trp Tyr Ser Ala Met Ala Gln Gly
     450                 455                 460                
 Gln Ala Ile Ser Thr Leu Val Arg Ala Tyr Leu Leu Thr Lys Asp His
 465                 470                 475                 480
 Ile Phe Leu Asn Ser Ala Leu Arg Ala Thr Ala Pro Tyr Lys Phe Leu
                 485                 490                 495    
 Ser Glu Gln His Gly Val Lys Ala Val Phe Met Asn Lys His Asp Trp
             500                 505                 510        
 Tyr Glu Glu Tyr Pro Thr Thr Pro Ser Ser Phe Val Leu Asn Gly Phe
         515                 520                 525            
 Met Tyr Ser Leu Ile Gly Leu Tyr Asp Leu Lys Glu Thr Ala Gly Glu
     530                 535                 540                
 Lys Leu Gly Lys Glu Ala Arg Ser Leu Tyr Glu Arg Gly Met Glu Ser
 545                 550                 555                 560
 Leu Lys Ala Met Leu Pro Leu Tyr Asp Thr Gly Ser Gly Thr Ile Tyr
                 565                 570                 575    
 Asp Leu Arg His Phe Met Leu Gly Ile Ala Pro Asn Leu Ala Arg Trp
             580                 585                 590        
 Asp Tyr His Thr Thr His Ile Asn Gln Leu Gln Leu Leu Ser Thr Ile
         595                 600                 605            
 Asp Glu Ser Pro Ile Phe Lys Glu Phe Val Lys Arg Trp Lys Ser Tyr
     610                 615                 620                
 Leu Lys Gly Ser Arg Ala Lys His Asn
 625                 630            



      <210> 967
      <211> 302
      <212> PRT
      <213> Homo sapiens


      <400> 967
 Met Glu Ala Glu Asn Leu Thr Glu Leu Ser Lys Phe Leu Leu Leu Gly
   1               5                  10                  15    
 Leu Ser Asp Asp Pro Glu Leu Gln Pro Val Leu Phe Gly Leu Phe Leu
              20                  25                  30        
 Ser Met Tyr Leu Val Thr Val Leu Gly Asn Leu Leu Ile Ile Leu Ala
          35                  40                  45            
 Val Ser Ser Asp Ser His Leu His Thr Pro Met Tyr Phe Phe Leu Ser
      50                  55                  60                
 Asn Leu Cys Trp Ala Asp Ile Gly Phe Thr Ser Ala Thr Val Pro Lys
  65                  70                  75                  80
 Ile Ile Val Asp Met Gln Ser His Ser Arg Val Ile Ser Tyr Val Gly
                  85                  90                  95    
 Cys Leu Thr Arg Met Ser Phe Leu Val Leu Phe Ala Cys Ile Glu Asp
             100                 105                 110        
 Met Leu Leu Thr Val Met Ala Tyr Asp Cys Phe Val Ala Ile Cys Arg
         115                 120                 125            
 Pro Leu His Tyr Pro Val Ile Val Asn Ala His Leu Arg Val Phe Leu
     130                 135                 140                
 Val Leu Val Ser Phe Phe Leu Ser Leu Leu Asp Ser Gln Leu His Arg
 145                 150                 155                 160
 Ile Leu Leu Ser Tyr Cys Lys Ile Val Pro Ser Ile Leu Arg Ile Ser
                 165                 170                 175    
 Thr Ser Asp Gly Lys Tyr Lys Ala Phe Ser Thr Cys Gly Ser His Leu
             180                 185                 190        
 Ala Leu Val Cys Leu Phe Tyr Gly Ala Gly Ile Gly Val Tyr Leu Thr
         195                 200                 205            
 Ser Ala Val Ser Pro Pro Pro Arg Asn Gly Val Val Val Ser Val Met
     210                 215                 220                
 Tyr Thr Val Val Thr Pro Met Leu Asn Pro Phe Ile Tyr Ser Leu Arg
 225                 230                 235                 240
 Asn Arg Asp Ile Gln Ser Thr Leu Arg Arg Leu Leu Ser Arg Thr Val
                 245                 250                 255    
 Glu Ser His Asp Leu Phe His Pro Phe Ser Cys Val Ala Gln Lys Lys
             260                 265                 270        
 Gly Val Phe Leu Ile Ala Met Ser Ile Lys Lys Glu Met Ile Asn Glu
         275                 280                 285            
 Ala Val Gly Val Phe Arg Leu Ala Cys Val Ile His Leu Pro
     290                 295                 300        



      <210> 968
      <211> 495
      <212> PRT
      <213> Homo sapiens


      <400> 968
 Met Trp Val Cys Ser Thr Leu Trp Arg Val Arg Thr Pro Ala Arg Gln
   1               5                  10                  15    
 Trp Arg Gly Leu Leu Pro Ala Ser Gly Cys His Gly Pro Ala Ala Ser
              20                  25                  30        
 Ser Tyr Ser Ala Ser Ala Glu Pro Ala Arg Val Arg Ala Leu Val Tyr
          35                  40                  45            
 Gly His His Gly Asp Pro Ala Lys Val Val Glu Gly Ile Thr Arg Glu
      50                  55                  60                
 Leu Phe Gln Arg Phe Pro Trp Ile Phe Leu Gln Leu Ile Thr Ala Val
  65                  70                  75                  80
 Ile Ser Ser Ala Ser Thr Val Leu Lys Asn Leu Glu Leu Ala Ala Val
                  85                  90                  95    
 Arg Gly Ser Asp Val Arg Val Lys Met Leu Ala Ala Pro Ile Asn Pro
             100                 105                 110        
 Ser Asp Ile Asn Met Met Val Gly Ala Ser Met Trp Val Cys Ser Thr
         115                 120                 125            
 Leu Trp Arg Val Arg Thr Pro Ala Arg Gln Trp Arg Gly Leu Leu Pro
     130                 135                 140                
 Ala Ser Gly Cys His Gly Pro Ala Ala Ser Ser Tyr Ser Ala Ser Ala
 145                 150                 155                 160
 Glu Pro Ala Arg Val Arg Ala Leu Val Tyr Gly His His Gly Asp Pro
                 165                 170                 175    
 Ala Lys Val Val Glu Leu Lys Asn Leu Glu Leu Ala Ala Val Arg Gly
             180                 185                 190        
 Ser Asp Val Arg Val Lys Met Leu Ala Ala Pro Ile Asn Pro Ser Asp
         195                 200                 205            
 Ile Asn Met Ile Gln Gly Asn Tyr Gly Leu Leu Pro Glu Leu Pro Ala
     210                 215                 220                
 Val Gly Gly Asn Glu Gly Val Ala Gln Val Val Ala Val Gly Ser Asn
 225                 230                 235                 240
 Val Thr Gly Leu Lys Pro Gly Asp Trp Val Ile Pro Ala Asn Ala Gly
                 245                 250                 255    
 Leu Gly Thr Trp Arg Thr Glu Ala Val Phe Ser Glu Glu Ala Leu Ile
             260                 265                 270        
 Gln Val Pro Ser Asp Ile Pro Leu Gln Ser Ala Ala Thr Leu Gly Val
         275                 280                 285            
 Asn Pro Cys Thr Ala Tyr Arg Met Leu Met Asp Phe Glu Gln Leu Gln
     290                 295                 300                
 Pro Gly Asp Ser Val Ile Gln Asn Ala Ser Asn Ser Gly Val Gly Gln
 305                 310                 315                 320
 Ala Val Ile Gln Ile Ala Ala Ala Leu Gly Leu Arg Thr Ile Asn Val
                 325                 330                 335    
 Val Arg Asp Arg Pro Asp Ile Gln Lys Leu Ser Asp Arg Leu Lys Ser
             340                 345                 350        
 Leu Gly Ala Glu His Val Ile Thr Glu Glu Glu Leu Arg Arg Pro Glu
         355                 360                 365            
 Met Lys Asn Phe Phe Lys Asp Met Pro Gln Pro Arg Leu Ala Leu Asn
     370                 375                 380                
 Cys Val Gly Gly Lys Ser Ser Thr Glu Leu Leu Arg Gln Leu Ala Arg
 385                 390                 395                 400
 Gly Gly Thr Met Val Thr Tyr Gly Gly Met Ala Lys Gln Pro Val Val
                 405                 410                 415    
 Ala Ser Val Ser Leu Leu Ile Phe Lys Asp Leu Lys Leu Arg Gly Phe
             420                 425                 430        
 Trp Leu Ser Gln Trp Lys Lys Asp His Ser Pro Asp Gln Phe Lys Glu
         435                 440                 445            
 Leu Ile Leu Thr Leu Cys Asp Leu Ile Arg Arg Gly Gln Leu Thr Ala
     450                 455                 460                
 Pro Ala Cys Ser Gln Val Pro Leu Gln Asp Tyr Gln Ser Ala Leu Glu
 465                 470                 475                 480
 Ala Ser Met Lys Pro Phe Ile Ser Ser Lys Gln Ile Leu Thr Met
                 485                 490                 495



      <210> 969
      <211> 921
      <212> PRT
      <213> Homo sapiens


      <400> 969
 Met Pro Ile Leu Leu Phe Leu Ile Asp Thr Ser Ala Ser Met Asn Gln
   1               5                  10                  15    
 Arg Thr Asp Leu Gly Thr Ser Tyr Leu Asp Ile Ala Lys Gly Ala Val
              20                  25                  30        
 Glu Leu Phe Leu Lys Leu Arg Ala Arg Asp Pro Ala Ser Arg Gly Asp
          35                  40                  45            
 Arg Tyr Met Leu Val Thr Tyr Asp Glu Pro Pro Tyr Cys Ile Lys Arg
      50                  55                  60                
 Gly Arg Ala Ser Arg Arg Pro Ser Lys Thr Arg Gln Pro Pro Leu His
  65                  70                  75                  80
 Ser Leu Ala Ser His His Pro Arg Ala Ile Gly Asn Leu Ser Ala Thr
                  85                  90                  95    
 Pro Val Ser Pro Pro Pro Asp Pro Glu Lys Val Phe Ala Phe Leu Leu
             100                 105                 110        
 Arg Asn Trp Pro Gly Ser Ala Pro Leu Ser Val Thr Leu Ala Thr Val
         115                 120                 125            
 Thr Val Ser Leu Glu Ile Pro Ala Lys Gln Arg His Gly Gly Gly Arg
     130                 135                 140                
 Ala Lys Gly Gly Thr Tyr Pro Phe Ser Thr Thr Cys Gln Arg Thr Tyr
 145                 150                 155                 160
 Gln Asn Ile Gln Lys Ser Phe Ser Asn Arg Pro Ala Glu Ser Met Pro
                 165                 170                 175    
 Val Ser Cys Leu Gln Thr Asn Gln Ser Asp Glu Lys Val Glu Met Trp
             180                 185                 190        
 Val Gln Arg Ala Gly Trp Lys Glu Asn His Ala Thr Phe Met Ser Glu
         195                 200                 205            
 Leu Lys Asn Leu Gln Ala Ser Gly Leu Thr Thr Leu Gly Gln Ala Leu
     210                 215                 220                
 Arg Ser Ser Phe Asp Leu Leu Asn Leu Asn Arg Leu Ile Ser Gly Ile
 225                 230                 235                 240
 Asp Asn Tyr Gly Gln Leu His Leu Pro Leu Asn Ser Pro Leu Pro Gly
                 245                 250                 255    
 Ser Glu Leu Thr Lys Glu Pro Phe Arg Trp Asp Gln Arg Leu Phe Ala
             260                 265                 270        
 Leu Val Leu Arg Leu Pro Gly Val Ala Ser Thr Glu Pro Glu Gln Leu
         275                 280                 285            
 Gly Ser Val Pro Thr Asp Glu Ser Ala Ile Thr Gln Met Cys Glu Val
     290                 295                 300                
 Thr Gly Gly Arg Ser Tyr Cys Val Arg Thr Gln Arg Met Leu Asn Gln
 305                 310                 315                 320
 Cys Leu Glu Ser Leu Val Gln Lys Val Gln Ser Gly Val Val Ile Asn
                 325                 330                 335    
 Phe Glu Lys Thr Gly Pro Asp Pro Leu Pro Ile Gly Glu Asp Gly Leu
             340                 345                 350        
 Met Asp Ser Ser Arg Pro Ser Asn Ser Phe Ala Ala Gln Pro Trp His
         355                 360                 365            
 Ser Cys His Lys Leu Ile Tyr Val Arg Pro Asn Ser Lys Thr Gly Val
     370                 375                 380                
 Pro Val Gly His Trp Pro Ile Pro Glu Ser Phe Trp Pro Asp Gln Asn
 385                 390                 395                 400
 Leu Pro Ser Leu Pro Pro Arg Thr Ser His Pro Val Val Arg Phe Ser
                 405                 410                 415    
 Cys Val Asp Cys Glu Pro Met Val Ile Asp Lys Leu Pro Phe Asp Lys
             420                 425                 430        
 Tyr Glu Leu Glu Pro Ser Pro Leu Thr Gln Tyr Ile Leu Glu Arg Lys
         435                 440                 445            
 Ser Pro His Thr Cys Trp Gln Val Phe Val Thr Ser Ser Gly Lys Tyr
     450                 455                 460                
 Asn Glu Leu Gly Tyr Pro Phe Gly Tyr Leu Lys Ala Ser Thr Thr Leu
 465                 470                 475                 480
 Thr Cys Val Asn Leu Phe Val Met Pro Tyr Asn Tyr Pro Val Leu Leu
                 485                 490                 495    
 Pro Leu Leu Asp Asp Leu Phe Lys Val His Lys Leu Lys Pro Asn Leu
             500                 505                 510        
 Lys Trp Arg Gln Ala Phe Asp Ser Tyr Leu Lys Thr Leu Pro Pro Tyr
         515                 520                 525            
 Tyr Leu Leu Thr Lys Leu Glu Ser Glu Arg Ile Leu Ala Ser Val Gly
     530                 535                 540                
 Lys Lys Pro Pro Gln Glu Ile Gly Ile Lys Val Lys Asn His Ser Gly
 545                 550                 555                 560
 Gly Gly Met Ser Leu Thr His Asn Lys Asn Phe Arg Lys Leu Leu Lys
                 565                 570                 575    
 Glu Ile Thr Gly Glu Thr Ala Leu Arg Leu Thr Glu Leu Asn Thr Lys
             580                 585                 590        
 Glu Phe Ala Gly Phe Gln Ile Gly Leu Leu Asn Lys Asp Leu Lys Pro
         595                 600                 605            
 Gln Thr Tyr Arg Asn Ala Tyr Asp Ile Pro Arg Arg Gly Leu Leu Asp
     610                 615                 620                
 Gln Leu Thr Arg Met Arg Ser Asn Leu Leu Lys Thr His Lys Phe Ile
 625                 630                 635                 640
 Val Gly Gln Asp Glu Asp Ser Leu His Ser Val Pro Val Ala Gln Met
                 645                 650                 655    
 Gly Asn Tyr Gln Glu Tyr Leu Lys Thr Leu Ala Ser Pro Leu Arg Glu
             660                 665                 670        
 Ile Asp Pro Asp Gln Pro Lys Arg Leu His Thr Phe Gly Asn Pro Phe
         675                 680                 685            
 Lys Gln Asp Lys Lys Gly Met Met Ile Asp Glu Ala Asp Glu Phe Val
     690                 695                 700                
 Ala Gly Pro Gln Asn Lys Val Lys Arg Pro Gly Glu Pro Asn Ser Pro
 705                 710                 715                 720
 Met Ser Ser Lys Arg Arg Arg Ser Met Ser Leu Leu Leu Arg Lys Pro
                 725                 730                 735    
 Gln Thr Pro Pro Thr Val Thr Asn His Leu Asn Leu Phe Ile Trp Phe
             740                 745                 750        
 Pro Asp Ala Thr Ile Ile His Asp Gly His Glu Glu Lys Met Glu Asn
         755                 760                 765            
 Gly Gln Ile Thr Pro Asp Gly Phe Leu Ser Lys Ser Ala Pro Ser Glu
     770                 775                 780                
 Leu Ile Asn Met Thr Gly Asp Leu Met Pro Pro Asn Gln Val Asp Ser
 785                 790                 795                 800
 Leu Ser Asp Asp Phe Thr Ser Leu Ser Lys Asp Gly Leu Ile Gln Lys
                 805                 810                 815    
 Pro Gly Ser Asn Ala Phe Val Gly Gly Ala Lys Asn Cys Ser Leu Ser
             820                 825                 830        
 Val Asp Asp Gln Lys Asp Pro Val Ala Ser Thr Leu Gly Ala Met Pro
         835                 840                 845            
 Asn Thr Leu Gln Ile Thr Pro Ala Met Ala Gln Gly Ile Asn Ala Asp
     850                 855                 860                
 Ile Lys His Gln Leu Met Lys Glu Val Arg Lys Phe Gly Arg Lys Tyr
 865                 870                 875                 880
 Glu Arg Ile Phe Ile Leu Leu Glu Glu Val Gln Gly Pro Leu Glu Met
                 885                 890                 895    
 Lys Lys Gln Phe Val Glu Phe Thr Ile Lys Glu Ala Ala Arg Ala Val
             900                 905                 910        
 Gly Pro Ser Ala Gly Lys Arg Glu Glu
         915                 920    



      <210> 970
      <211> 453
      <212> PRT
      <213> Homo sapiens


      <400> 970
 Met Val Arg Lys Leu Ala Val Trp Ala Trp Arg Pro Ala Ser Thr Pro
   1               5                  10                  15    
 Gln Thr His Ser Leu Lys Thr Arg Gln Ala Ser Arg Val Leu Val Ala
              20                  25                  30        
 Ser Arg Leu Gly His Leu Lys Glu Thr Trp Gly His Pro Arg Arg Ala
          35                  40                  45            
 Ser Trp Val Val Arg Ser Arg Arg Cys Arg His Cys Leu Cys Phe Met
      50                  55                  60                
 Arg Lys Met Leu Ala Ala Val Ser Arg Val Leu Ser Gly Ala Ser Gln
  65                  70                  75                  80
 Lys Pro Ala Ser Arg Val Leu Val Ala Ser Arg Asn Phe Ala Asn Asp
                  85                  90                  95    
 Ala Thr Phe Glu Ile Lys Lys Cys Asp Leu His Arg Leu Glu Glu Gly
             100                 105                 110        
 Pro Pro Val Thr Thr Val Leu Thr Arg Glu Asp Gly Leu Lys Tyr Tyr
         115                 120                 125            
 Arg Met Met Gln Thr Val Arg Arg Met Glu Leu Lys Ala Asp Gln Leu
     130                 135                 140                
 Tyr Lys Gln Lys Ile Ile Arg Gly Phe Cys His Leu Cys Asp Gly Gln
 145                 150                 155                 160
 Glu Ala Cys Cys Val Gly Leu Glu Ala Gly Ile Asn Pro Thr Asp His
                 165                 170                 175    
 Leu Ile Thr Ala Tyr Arg Ala His Gly Phe Thr Phe Thr Arg Gly Leu
             180                 185                 190        
 Ser Val Arg Glu Ile Leu Ala Glu Leu Thr Gly Arg Lys Gly Gly Cys
         195                 200                 205            
 Ala Lys Gly Lys Gly Gly Ser Met His Met Tyr Ala Lys Asn Phe Tyr
     210                 215                 220                
 Gly Gly Asn Gly Ile Val Gly Ala Gln Val Pro Leu Gly Ala Gly Ile
 225                 230                 235                 240
 Ala Leu Ala Cys Lys Tyr Asn Gly Lys Asp Glu Val Cys Leu Thr Leu
                 245                 250                 255    
 Tyr Gly Asp Gly Ala Ala Asn Gln Gly Gln Ile Phe Glu Ala Tyr Asn
             260                 265                 270        
 Met Ala Ala Leu Trp Lys Leu Pro Cys Ile Phe Ile Cys Glu Asn Asn
         275                 280                 285            
 Arg Tyr Gly Met Gly Thr Ser Val Glu Arg Ala Ala Ala Ser Thr Asp
     290                 295                 300                
 Tyr Tyr Lys Arg Gly Asp Phe Ile Pro Gly Leu Arg Val Asp Gly Met
 305                 310                 315                 320
 Asp Ile Leu Cys Val Arg Glu Ala Thr Arg Phe Ala Ala Ala Tyr Cys
                 325                 330                 335    
 Arg Ser Gly Lys Gly Pro Ile Leu Met Glu Leu Gln Thr Tyr Arg Tyr
             340                 345                 350        
 His Gly His Ser Met Ser Asp Pro Gly Val Ser Tyr Arg Thr Arg Glu
         355                 360                 365            
 Glu Ile Gln Glu Val Arg Ser Lys Ser Asp Pro Ile Met Leu Leu Lys
     370                 375                 380                
 Asp Arg Met Val Asn Ser Asn Leu Ala Ser Val Glu Glu Leu Lys Glu
 385                 390                 395                 400
 Ile Asp Val Glu Val Arg Lys Glu Ile Glu Asp Ala Ala Gln Phe Ala
                 405                 410                 415    
 Thr Ala Asp Pro Glu Pro Pro Leu Glu Glu Leu Gly Tyr His Ile Tyr
             420                 425                 430        
 Ser Ser Asp Pro Pro Phe Glu Val Arg Gly Ala Asn Gln Trp Ile Lys
         435                 440                 445            
 Phe Lys Ser Val Ser
     450            



      <210> 971
      <211> 180
      <212> PRT
      <213> Homo sapiens


      <400> 971
 Met Leu Ser Pro Asp Leu Pro Asp Ser Ala Trp Asn Thr Arg Leu Leu
   1               5                  10                  15    
 Cys Arg Val Met Leu Cys Leu Leu Gly Ala Gly Ser Val Ala Ala Gly
              20                  25                  30        
 Val Ile Gln Ser Pro Arg His Leu Ile Lys Glu Lys Arg Glu Thr Ala
          35                  40                  45            
 Thr Leu Lys Cys Tyr Pro Ile Pro Arg His Asp Thr Val Tyr Trp Tyr
      50                  55                  60                
 Gln Gln Gly Pro Gly Gln Asp Pro Gln Phe Leu Ile Ser Phe Tyr Glu
  65                  70                  75                  80
 Lys Met Gln Ser Asp Lys Gly Ser Ile Pro Asp Arg Phe Ser Ala Gln
                  85                  90                  95    
 Gln Phe Ser Asp Tyr His Ser Glu Leu Asn Met Ser Ser Leu Glu Leu
             100                 105                 110        
 Gly Asp Ser Ala Leu Tyr Phe Cys Ala Ser Ser Arg Gly Glu Leu Arg
         115                 120                 125            
 Tyr Gly Ile Tyr Glu Gln Tyr Phe Gly Pro Gly Thr Arg Leu Thr Val
     130                 135                 140                
 Thr Glu Asp Leu Lys Asn Val Phe Pro Pro Glu Val Ala Val Phe Glu
 145                 150                 155                 160
 Pro Ser Glu Ala Glu Ile Ser His Thr Gln Lys Ala Thr Leu Leu Cys
                 165                 170                 175    
 Leu Val Thr Gly
             180



      <210> 972
      <211> 270
      <212> PRT
      <213> Homo sapiens


      <400> 972
 Met Ala Thr Pro Pro Phe Arg Leu Ile Arg Lys Met Phe Ser Phe Lys
   1               5                  10                  15    
 Val Ser Arg Trp Met Gly Leu Ala Cys Phe Arg Ser Leu Ala Ala Ser
              20                  25                  30        
 Ser Pro Ser Ile Arg Gln Lys Lys Leu Met His Lys Leu Gln Glu Glu
          35                  40                  45            
 Lys Ala Phe Arg Glu Glu Met Lys Ile Phe Arg Glu Lys Ile Glu Asp
      50                  55                  60                
 Phe Arg Glu Glu Met Trp Thr Phe Arg Gly Lys Ile His Ala Phe Arg
  65                  70                  75                  80
 Gly Gln Ile Leu Gly Phe Trp Glu Glu Glu Arg Pro Phe Trp Glu Glu
                  85                  90                  95    
 Glu Lys Thr Phe Trp Lys Glu Glu Lys Ser Phe Trp Glu Met Glu Lys
             100                 105                 110        
 Ser Phe Arg Glu Glu Glu Lys Thr Phe Trp Lys Lys Tyr Arg Thr Phe
         115                 120                 125            
 Trp Lys Glu Asp Lys Ala Phe Trp Lys Glu Asp Asn Ala Leu Trp Glu
     130                 135                 140                
 Arg Asp Arg Asn Leu Leu Gln Glu Asp Lys Ala Leu Trp Glu Glu Glu
 145                 150                 155                 160
 Lys Ala Leu Trp Val Glu Glu Arg Ala Leu Leu Glu Gly Glu Lys Ala
                 165                 170                 175    
 Leu Trp Glu Asp Lys Thr Ser Leu Trp Glu Glu Glu Asn Ala Leu Trp
             180                 185                 190        
 Glu Glu Glu Arg Ala Phe Trp Met Glu Asn Asn Gly His Ile Ala Gly
         195                 200                 205            
 Glu Gln Met Leu Glu Asp Gly Pro His Asn Ala Asn Arg Gly Gln Arg
     210                 215                 220                
 Leu Leu Ala Phe Ser Arg Gly Arg Arg Ser Gln His Ala Gly Ala Gly
 225                 230                 235                 240
 Pro Cys Gly Pro Asp Ser Pro Gly Leu Gly Phe Lys Ser Arg Val Ser
                 245                 250                 255    
 Pro Cys Ala Gly Glu Asn Thr His Ser Leu Val Ser Leu Leu
             260                 265                 270



      <210> 973
      <211> 584
      <212> PRT
      <213> Homo sapiens


      <400> 973
 Met Val Met Ser Phe Arg Val Ser Glu Leu Gln Val Leu Leu Gly Phe
   1               5                  10                  15    
 Ala Gly Arg Asn Lys Ser Gly Arg Lys His Glu Leu Leu Ala Lys Ala
              20                  25                  30        
 Leu His Leu Leu Lys Ser Ser Cys Ala Pro Ser Val Gln Met Lys Ile
          35                  40                  45            
 Lys Glu Leu Tyr Arg Arg Arg Phe Pro Arg Lys Thr Leu Gly Pro Ser
      50                  55                  60                
 Asp Leu Ser Leu Leu Ser Leu Pro Pro Gly Thr Ser Pro Pro Val His
  65                  70                  75                  80
 Pro Asp Val Thr Met Lys Pro Leu Pro Phe Tyr Glu Val Tyr Gly Glu
                  85                  90                  95    
 Leu Ile Arg Pro Thr Thr Leu Ala Ser Thr Ser Ser Gln Arg Phe Glu
             100                 105                 110        
 Glu Ala His Phe Thr Phe Ala Leu Thr Pro Gln Gln Val Gln Gln Ile
         115                 120                 125            
 Leu Thr Ser Arg Glu Val Leu Pro Gly Ala Lys Cys Asp Tyr Thr Ile
     130                 135                 140                
 Gln Val Gln Leu Arg Phe Cys Leu Cys Glu Thr Ser Cys Pro Gln Glu
 145                 150                 155                 160
 Asp Tyr Phe Pro Pro Asn Leu Phe Val Lys Val Asn Gly Lys Leu Cys
                 165                 170                 175    
 Pro Leu Pro Gly Tyr Leu Pro Pro Thr Lys Asn Gly Ala Glu Pro Lys
             180                 185                 190        
 Arg Pro Ser Arg Pro Ile Asn Ile Thr Pro Leu Ala Arg Leu Ser Ala
         195                 200                 205            
 Thr Val Pro Asn Thr Ile Val Val Asn Trp Ser Ser Glu Phe Gly Arg
     210                 215                 220                
 Asn Tyr Ser Leu Ser Val Tyr Leu Val Arg Gln Leu Thr Ala Gly Thr
 225                 230                 235                 240
 Leu Leu Gln Lys Leu Arg Ala Lys Gly Ile Arg Asn Pro Asp His Ser
                 245                 250                 255    
 Arg Ala Leu Ile Lys Glu Lys Leu Thr Ala Asp Pro Asp Ser Glu Val
             260                 265                 270        
 Ala Thr Thr Ser Leu Arg Val Ser Leu Met Cys Pro Leu Gly Lys Met
         275                 280                 285            
 Arg Leu Thr Val Pro Cys Arg Ala Leu Thr Cys Ala His Leu Gln Ser
     290                 295                 300                
 Phe Asp Ala Ala Leu Tyr Leu Gln Met Asn Glu Lys Lys Pro Thr Trp
 305                 310                 315                 320
 Thr Cys Pro Val Cys Asp Lys Lys Ala Pro Tyr Glu Ser Leu Ile Ile
                 325                 330                 335    
 Asp Gly Leu Phe Met Glu Ile Leu Ser Ser Cys Ser Asp Cys Asp Glu
             340                 345                 350        
 Ile Gln Phe Met Glu Asp Gly Ser Trp Cys Pro Met Lys Pro Lys Lys
         355                 360                 365            
 Glu Ala Ser Glu Val Cys Pro Pro Pro Gly Tyr Gly Leu Asp Gly Leu
     370                 375                 380                
 Gln Tyr Ser Pro Val Gln Gly Gly Asp Pro Ser Glu Asn Lys Lys Lys
 385                 390                 395                 400
 Val Glu Val Ile Asp Leu Thr Ile Glu Ser Ser Ser Asp Glu Glu Asp
                 405                 410                 415    
 Leu Pro Pro Thr Lys Lys His Cys Ser Val Thr Ser Ala Ala Ile Pro
             420                 425                 430        
 Ala Leu Pro Gly Ser Lys Gly Val Leu Thr Ser Gly His Gln Pro Ser
         435                 440                 445            
 Ser Val Leu Arg Ser Pro Ala Met Gly Thr Leu Gly Gly Asp Phe Leu
     450                 455                 460                
 Ser Ser Leu Pro Leu His Glu Tyr Pro Pro Ala Phe Pro Leu Gly Ala
 465                 470                 475                 480
 Asp Ile Gln Gly Leu Asp Leu Phe Ser Phe Leu Gln Thr Glu Ser Gln
                 485                 490                 495    
 His Tyr Gly Pro Ser Val Ile Thr Ser Leu Asp Glu Gln Asp Ala Leu
             500                 505                 510        
 Gly His Phe Phe Gln Tyr Arg Gly Thr Pro Ser His Phe Leu Gly Pro
         515                 520                 525            
 Leu Ala Pro Thr Leu Gly Ser Ser His Cys Ser Ala Thr Pro Ala Pro
     530                 535                 540                
 Pro Pro Gly Arg Val Ser Ser Ile Val Ala Pro Gly Gly Ala Leu Arg
 545                 550                 555                 560
 Glu Gly His Gly Gly Pro Leu Pro Ser Gly Pro Ser Leu Thr Gly Cys
                 565                 570                 575    
 Arg Ser Asp Ile Ile Ser Leu Asp
             580                



      <210> 974
      <211> 282
      <212> PRT
      <213> Homo sapiens


      <400> 974
 Met Lys Val Glu Phe Ala Pro Leu Asn Ile Gln Leu Ala Arg Arg Leu
   1               5                  10                  15    
 Gln Thr Val Ala Val Leu Gln Trp Val Leu Lys Tyr Leu Leu Leu Gly
              20                  25                  30        
 Pro Met Ser Ile Gly Ile Thr Val Met Leu Ile Ile His Asn Tyr Leu
          35                  40                  45            
 Phe Leu Tyr Ile Pro Tyr Leu Met Gly Leu Tyr Phe Asp Trp His Thr
      50                  55                  60                
 Pro Glu Arg Gly Gly Arg Arg Ser Ser Trp Ile Lys Asn Trp Thr Leu
  65                  70                  75                  80
 Trp Lys His Phe Lys Asp Tyr Phe Pro Ile Gln Gly Leu Val Ser Val
                  85                  90                  95    
 Ser Lys Lys Ser Val Ser Tyr Met Val Ser Lys Glu Gly Gly Gly Asn
             100                 105                 110        
 Ile Ser Val Ile Val Leu Gly Gly Ala Lys Glu Ser Leu Asp Ala His
         115                 120                 125            
 Pro Gly Lys Phe Thr Leu Phe Ile Arg Gln Arg Lys Gly Phe Val Lys
     130                 135                 140                
 Ile Ala Leu Thr His Gly Ala Ser Leu Val Pro Val Val Ser Phe Gly
 145                 150                 155                 160
 Glu Asn Glu Leu Phe Lys Gln Thr Asp Asn Pro Glu Gly Ser Trp Ile
                 165                 170                 175    
 Arg Thr Val Gln Asn Lys Leu Gln Lys Ile Met Gly Phe Ala Leu Pro
             180                 185                 190        
 Leu Phe His Ala Arg Gly Val Phe Gln Tyr Asn Phe Gly Leu Met Thr
         195                 200                 205            
 Tyr Arg Lys Ala Ile His Thr Val Val Gly Arg Pro Ile Pro Val Arg
     210                 215                 220                
 Gln Thr Leu Asn Pro Thr Gln Glu Gln Ile Glu Glu Leu His Gln Thr
 225                 230                 235                 240
 Tyr Met Glu Glu Leu Arg Lys Leu Phe Glu Glu His Lys Gly Lys Gly
                 245                 250                 255    
 Met Arg Phe Asn Leu Thr Ala Ser Ser Glu Glu Val Lys Leu Thr Thr
             260                 265                 270        
 Gln His Pro Leu Gly Tyr Pro Ala Gly Ser
         275                 280        



      <210> 975
      <211> 611
      <212> PRT
      <213> Homo sapiens


      <400> 975
 Met His Leu Thr Leu Ser Leu Leu Leu Phe Ser Leu His Phe Pro Thr
   1               5                  10                  15    
 Tyr Ile Ile Arg Val Asn Phe Cys Leu Val Ser Asn Leu Phe Gln Arg
              20                  25                  30        
 Met Arg Ser Thr Lys Leu Leu Arg Leu Ile Asp Leu Asp Phe Ser Phe
          35                  40                  45            
 Thr Phe Ser Leu Leu Asp Leu Pro Pro Val Asn Glu Tyr Asp Met Tyr
      50                  55                  60                
 Ile Arg Asn Phe Gly Lys Lys Asn Thr Lys Gln Ala Tyr Val Gln Cys
  65                  70                  75                  80
 Asn Glu Asp Asn Val Glu Arg Asp Ile Gln Thr Glu Glu Ile Glu Thr
                  85                  90                  95    
 Arg Glu Val Trp Thr Gln His Pro Gly Glu Ser Thr Val Val Ser Gly
             100                 105                 110        
 Gly Ser Glu Gln Arg Asp Thr Ser Asp Ala Val Val Met Pro Lys Ile
         115                 120                 125            
 Asp Thr Pro Arg Leu Cys Ser Phe Leu Arg Ala Ala Cys Gln Val Met
     130                 135                 140                
 Ala Val Leu Leu Glu Glu Asp Arg Leu Ala Ala Glu Pro Ser Trp Asn
 145                 150                 155                 160
 Leu Arg Ala Gln Asp Arg Ala Leu Tyr Phe Ser Asp Ser Ser Ser Gln
                 165                 170                 175    
 Leu Asn Thr Ser Leu Pro Phe Leu Gln Asn Arg Lys Val Ser Ser Leu
             180                 185                 190        
 His Thr Ser Arg Val Gln Arg Gln Met Val Val Ser Val His Asp Leu
         195                 200                 205            
 Pro Glu Lys Ser Phe Val Pro Leu Leu Asp Ser Lys Tyr Val Leu Cys
     210                 215                 220                
 Val Trp Asp Ile Trp Gln Pro Ser Gly Pro Gln Lys Val Leu Ile Cys
 225                 230                 235                 240
 Glu Ser Gln Val Thr Cys Cys Cys Leu Ser Pro Leu Lys Ala Phe Leu
                 245                 250                 255    
 Leu Phe Ala Gly Thr Ala His Gly Ser Val Val Val Trp Asp Leu Arg
             260                 265                 270        
 Glu Asp Ser Arg Leu His Tyr Ser Val Thr Leu Ser Asp Gly Phe Trp
         275                 280                 285            
 Thr Phe Arg Thr Ala Thr Phe Ser Thr Asp Gly Ile Leu Thr Ser Val
     290                 295                 300                
 Asn His Arg Ser Pro Leu Gln Ala Val Glu Pro Ile Ser Thr Ser Val
 305                 310                 315                 320
 His Lys Lys Gln Ser Phe Val Leu Ser Pro Phe Ser Thr Gln Glu Glu
                 325                 330                 335    
 Met Ser Gly Leu Ser Phe His Ile Ala Ser Leu Asp Glu Ser Gly Val
             340                 345                 350        
 Leu Asn Val Trp Val Val Val Glu Leu Pro Lys Ala Asp Ile Ala Gly
         355                 360                 365            
 Ser Ile Ser Asp Leu Gly Leu Met Pro Gly Gly Arg Val Lys Leu Val
     370                 375                 380                
 His Ser Ala Leu Ile Gln Leu Gly Asp Ser Leu Ser His Lys Gly Asn
 385                 390                 395                 400
 Glu Phe Trp Gly Thr Thr Gln Thr Leu Asn Val Lys Phe Leu Pro Ser
                 405                 410                 415    
 Asp Pro Asn His Phe Ile Ile Gly Thr Asp Met Gly Leu Ile Ser His
             420                 425                 430        
 Gly Thr Arg Gln Asp Leu Arg Val Ala Pro Lys Leu Phe Lys Pro Gln
         435                 440                 445            
 Gln His Gly Ile Arg Pro Val Lys Val Asn Val Ile Asp Phe Ser Pro
     450                 455                 460                
 Phe Gly Glu Pro Ile Phe Leu Ala Gly Cys Ser Asp Gly Ser Ile Arg
 465                 470                 475                 480
 Leu His Gln Leu Ser Ser Ala Phe Pro Leu Leu Gln Trp Asp Ser Ser
                 485                 490                 495    
 Thr Asp Ser His Ala Val Thr Gly Leu Gln Trp Ser Pro Thr Arg Pro
             500                 505                 510        
 Ala Val Phe Leu Val Gln Asp Asp Thr Ser Asn Ile Tyr Ile Trp Asp
         515                 520                 525            
 Leu Leu Gln Ser Asp Leu Gly Pro Val Ala Lys Gln Gln Val Ser Pro
     530                 535                 540                
 Asn Arg Leu Val Ala Met Ala Ala Val Gly Glu Pro Glu Lys Ala Gly
 545                 550                 555                 560
 Gly Ser Phe Leu Ala Leu Val Leu Ala Arg Ala Ser Gly Ser Ile Asp
                 565                 570                 575    
 Ile Gln His Leu Lys Arg Arg Trp Ala Ala Pro Glu Val Asp Glu Cys
             580                 585                 590        
 Asn Arg Leu Arg Leu Leu Leu Gln Glu Ala Leu Trp Pro Glu Gly Lys
         595                 600                 605            
 Leu His Lys
     610    



      <210> 976
      <211> 130
      <212> PRT
      <213> Homo sapiens


      <400> 976
 Met Thr Leu Leu Ala Gln Glu Trp Gly Ala Ala Ser His Leu Leu Leu
   1               5                  10                  15    
 Trp Gly Arg Val Ser Pro Gly Ser Gly Pro Arg Trp Arg Ile Cys Ser
              20                  25                  30        
 Met Ser Cys Asp Val Leu Gln Pro Arg Val Thr Glu Ser Leu Leu Trp
          35                  40                  45            
 Ala Thr Lys Ser Thr Gln Pro Leu Ala Met Gly His Pro Ala Gly Pro
      50                  55                  60                
 Leu Asp Thr Glu Thr Cys Gly Ser Gln Pro Val Val Ile Leu Cys Pro
  65                  70                  75                  80
 Gly Asn Thr Trp Pro Ser Leu Gly Ser Ile Leu Phe Val Thr Val Tyr
                  85                  90                  95    
 Gly Trp Gly Val Thr Arg His Pro Thr Val His Arg Thr Ala His Ser
             100                 105                 110        
 Arg His Pro Thr Val Ser Ser Thr Ser Arg Lys Pro Gly Leu Lys Arg
         115                 120                 125            
 Ser Leu
     130



      <210> 977
      <211> 735
      <212> PRT
      <213> Homo sapiens


      <400> 977
 Met Arg Val Leu Leu His Leu Pro Ala Leu Leu Ala Ser Leu Ile Leu
   1               5                  10                  15    
 Leu Gln Ala Ala Ala Ser Thr Thr Arg Ala Gln Thr Thr Arg Thr Ser
              20                  25                  30        
 Ala Ile Ser Asp Thr Val Ser Gln Ala Lys Val Gln Val Asn Lys Ala
          35                  40                  45            
 Phe Leu Asp Ser Arg Thr Arg Leu Lys Thr Ala Met Ser Ser Glu Thr
      50                  55                  60                
 Pro Thr Ser Arg Gln Leu Ser Glu Tyr Leu Lys His Ala Lys Gly Arg
  65                  70                  75                  80
 Thr Arg Thr Ala Ile Arg Asn Gly Gln Val Trp Glu Glu Ser Leu Lys
                  85                  90                  95    
 Arg Leu Arg Gln Lys Ala Ser Leu Thr Asn Val Thr Asp Pro Ser Leu
             100                 105                 110        
 Asp Leu Thr Ser Leu Ser Leu Glu Val Gly Cys Gly Ala Pro Ala Pro
         115                 120                 125            
 Val Val Arg Cys Asp Pro Cys Ser Pro Tyr Arg Thr Ile Thr Gly Asp
     130                 135                 140                
 Cys Asn Asn Arg Arg Lys Pro Ala Leu Gly Ala Ala Asn Arg Ala Leu
 145                 150                 155                 160
 Ala Arg Trp Leu Pro Ala Glu Tyr Glu Asp Gly Leu Ser Leu Pro Phe
                 165                 170                 175    
 Gly Trp Thr Pro Gly Lys Thr Arg Asn Gly Phe Pro Leu Pro Leu Ala
             180                 185                 190        
 Arg Glu Val Ser Asn Lys Ile Val Gly Tyr Leu Asn Glu Glu Gly Val
         195                 200                 205            
 Leu Asp Gln Asn Arg Ser Leu Leu Phe Met Gln Trp Gly Gln Ile Val
     210                 215                 220                
 Asp His Asp Leu Asp Phe Ala Pro Asp Thr Glu Leu Gly Ser Ser Glu
 225                 230                 235                 240
 Tyr Ser Lys Ala Gln Cys Asp Glu Tyr Cys Ile Gln Gly Asp Asn Cys
                 245                 250                 255    
 Phe Pro Ile Met Phe Pro Pro Asn Asp Pro Lys Ala Gly Thr Gln Gly
             260                 265                 270        
 Lys Cys Met Pro Phe Phe Arg Ala Gly Phe Val Cys Pro Thr Pro Pro
         275                 280                 285            
 Tyr Lys Ser Leu Ala Arg Glu Gln Ile Asn Ala Leu Thr Ser Phe Leu
     290                 295                 300                
 Asp Ala Ser Phe Val Tyr Ser Ser Glu Pro Ser Leu Ala Ser Arg Leu
 305                 310                 315                 320
 Arg Asn Leu Ser Ser Pro Leu Gly Leu Met Ala Val Asn Gln Glu Val
                 325                 330                 335    
 Ser Asp His Gly Leu Pro Tyr Leu Pro Tyr Asp Ser Lys Lys Pro Ser
             340                 345                 350        
 Pro Cys Glu Phe Ile Asn Thr Thr Ala Arg Val Pro Cys Phe Leu Ala
         355                 360                 365            
 Gly Asp Ser Arg Ala Ser Glu His Ile Leu Leu Ala Thr Ser His Thr
     370                 375                 380                
 Leu Phe Leu Arg Glu His Asn Arg Leu Ala Arg Glu Leu Lys Arg Leu
 385                 390                 395                 400
 Asn Pro Gln Trp Asp Gly Glu Lys Leu Tyr Gln Glu Ala Arg Lys Ile
                 405                 410                 415    
 Leu Gly Ala Phe Val Gln Ile Ile Thr Phe Arg Asp Tyr Leu Pro Ile
             420                 425                 430        
 Leu Leu Gly Asp His Met Gln Lys Trp Ile Pro Pro Tyr Gln Gly Tyr
         435                 440                 445            
 Ser Glu Ser Val Asp Pro Arg Ile Ser Asn Val Phe Thr Phe Ala Phe
     450                 455                 460                
 Arg Phe Gly His Leu Glu Val Pro Ser Ser Met Phe Arg Leu Asp Glu
 465                 470                 475                 480
 Asn Tyr Gln Pro Trp Gly Pro Glu Pro Glu Leu Pro Leu His Thr Leu
                 485                 490                 495    
 Phe Phe Asn Thr Trp Arg Met Val Lys Asp Gly Gly Ile Asp Pro Leu
             500                 505                 510        
 Val Arg Gly Leu Leu Ala Lys Lys Ser Lys Leu Met Lys Gln Asn Lys
         515                 520                 525            
 Met Met Thr Gly Glu Leu Arg Asn Lys Leu Phe Gln Pro Thr His Arg
     530                 535                 540                
 Ile His Gly Phe Asp Leu Ala Ala Ile Asn Thr Gln Arg Cys Arg Asp
 545                 550                 555                 560
 His Gly Gln Pro Gly Tyr Asn Ser Trp Arg Ala Phe Cys Asp Leu Ser
                 565                 570                 575    
 Gln Pro Gln Thr Leu Glu Glu Leu Asn Thr Val Leu Lys Ser Lys Met
             580                 585                 590        
 Leu Ala Lys Lys Leu Leu Gly Leu Tyr Gly Thr Pro Asp Asn Ile Asp
         595                 600                 605            
 Ile Trp Ile Gly Ala Ile Ala Glu Pro Leu Val Glu Arg Gly Arg Val
     610                 615                 620                
 Gly Pro Leu Leu Ala Cys Leu Leu Gly Lys Gln Phe Gln Gln Ile Arg
 625                 630                 635                 640
 Asp Gly Asp Arg Gln Val Arg Pro Gln Pro Gly Arg Glu Gly Gln Gly
                 645                 650                 655    
 Pro Ser Pro Arg Gly Val Ser Gln Gly Pro Ala Phe Trp Trp Glu Asn
             660                 665                 670        
 Pro Gly Val Phe Thr Asn Glu Gln Lys Asp Ser Leu Gln Lys Met Ser
         675                 680                 685            
 Phe Ser Arg Leu Val Cys Asp Asn Thr Arg Ile Thr Lys Val Pro Arg
     690                 695                 700                
 Asp Pro Phe Trp Ala Asn Ser Tyr Pro Tyr Asp Phe Val Asp Cys Ser
 705                 710                 715                 720
 Ala Ile Asp Lys Leu Asp Leu Ser Pro Trp Ala Ser Val Lys Asn
                 725                 730                 735



      <210> 978
      <211> 124
      <212> PRT
      <213> Homo sapiens


      <400> 978
 Met Val Leu Ala His Ile Gln Tyr Leu Asp Pro Cys Leu Ala Ala Leu
   1               5                  10                  15    
 Leu Ala His Ala Leu Leu Arg Thr Leu Gln Val Thr Thr Val Arg Arg
              20                  25                  30        
 Thr Leu Thr Leu Leu Ser Ala Phe Leu Leu Val Ala Leu Gln Ala Trp
          35                  40                  45            
 Ala Glu Pro Leu Pro Ala Arg Ala His Glu Met Pro Ala Gln Lys Gln
      50                  55                  60                
 Pro Pro Ala Asp Asp Gln Asp Val Val Leu Tyr Phe Ser Gly Asp Asp
  65                  70                  75                  80
 Ser Cys Ser Leu Gln Val Pro Gly Ser Thr Lys Gly Leu Ile Cys His
                  85                  90                  95    
 Cys Arg Val Leu Tyr Cys Ile Phe Gly Glu His Leu Gly Gly Thr Cys
             100                 105                 110        
 Phe Ile Leu Gly Glu Arg Tyr Pro Ile Cys Cys Tyr
         115                 120                



      <210> 979
      <211> 156
      <212> PRT
      <213> Homo sapiens


      <400> 979
 Met Glu Ala Leu Arg Arg Ala His Glu Val Ala Leu Arg Leu Leu Leu
   1               5                  10                  15    
 Cys Arg Pro Trp Ala Ser Arg Ala Ala Ala Arg Pro Lys Pro Ser Ala
              20                  25                  30        
 Ser Glu Val Leu Thr Arg His Leu Leu Gln Arg Arg Leu Pro His Trp
          35                  40                  45            
 Thr Ser Phe Cys Val Pro Tyr Ser Ala Val Arg Asn Asp Gln Phe Gly
      50                  55                  60                
 Leu Ser His Phe Asn Trp Pro Val Gln Gly Ala Asn Tyr His Val Leu
  65                  70                  75                  80
 Arg Thr Gly Cys Phe Pro Phe Ile Lys Tyr His Cys Ser Lys Ala Pro
                  85                  90                  95    
 Trp Gln Asp Leu Ala Arg Gln Asn Arg Phe Phe Thr Ala Leu Lys Val
             100                 105                 110        
 Val Asn Leu Gly Ile Pro Thr Leu Leu Tyr Gly Leu Gly Ser Trp Leu
         115                 120                 125            
 Phe Ala Arg Val Thr Glu Thr Val His Thr Ser Tyr Gly Pro Ile Thr
     130                 135                 140                
 Val Tyr Phe Leu Asn Lys Glu Asp Glu Gly Ala Met
 145                 150                 155    



      <210> 980
      <211> 169
      <212> PRT
      <213> Homo sapiens


      <400> 980
 Met Leu Leu Thr Leu Ser Gly Leu Leu Leu Phe Glu Lys Pro Met Gly
   1               5                  10                  15    
 Ile Cys Phe Ile Val Val Ser Phe Asn Ser Tyr Leu Ala Glu Ser Ile
              20                  25                  30        
 Ser Gln Gly Lys Tyr Cys Ser Val Met Val Ser Trp Thr Leu Phe Ser
          35                  40                  45            
 Ile Cys Phe Ser Thr Ser Ile Asn Gly Leu Leu Pro Ala Ile Met Thr
      50                  55                  60                
 Cys Met His Leu Leu Ser Ser Phe Ser Lys Gln Asn Lys Leu Cys Gly
  65                  70                  75                  80
 Cys Ile Ser Arg Thr Leu Ser His Phe Gln Asp Ser Ile Glu Leu Glu
                  85                  90                  95    
 Thr His Ile Asp Thr Ser Thr Gln Leu Tyr Val Tyr Thr Glu His Ile
             100                 105                 110        
 Tyr Ser Asp Ile Phe Arg Lys Ile Arg Lys Lys Lys Ile Gly Trp Thr
         115                 120                 125            
 Ile Gln Ile Trp Lys Tyr Ser Leu Phe Asn His Leu Glu Pro Ile Leu
     130                 135                 140                
 Leu Thr Val Tyr Ile Cys Arg Arg Asp Phe Val Lys Lys Thr His Met
 145                 150                 155                 160
 Cys Val Tyr Thr Gln Ala Ser Ser Ser
                 165                



      <210> 981
      <211> 215
      <212> PRT
      <213> Homo sapiens


      <400> 981
 Met Gly Phe Val Phe Phe Ile Phe Phe Phe Cys Lys Asp Cys His Thr
   1               5                  10                  15    
 Lys Glu Phe Leu Ile Ile Phe Cys Val Val Pro Ile Ala Ala Ser Gln
              20                  25                  30        
 Lys Ser Ser Asn Leu Glu Gly Arg Thr Lys Ser Val Thr Arg Gln Thr
          35                  40                  45            
 Gly Ser Ser Ala Glu Ile Thr Cys Asp Leu Thr Val Ile Asn Ala Phe
      50                  55                  60                
 Tyr Ile His Trp Tyr Leu His Gln Glu Gly Lys Ala Pro Gln Arg Leu
  65                  70                  75                  80
 Leu Tyr Tyr Asp Val Ser Asn Ser Arg Asp Val Leu Glu Ser Gly Leu
                  85                  90                  95    
 Ser Pro Gly Lys Tyr Tyr Thr His Thr Pro Arg Arg Trp Ser Trp Asn
             100                 105                 110        
 Leu Arg Leu Gln Asn Leu Ile Glu Asn Asp Ser Gly Val Tyr Tyr Cys
         115                 120                 125            
 Ala Thr Trp Gly Arg His Ser Asp Ser Asp Leu Pro Tyr Thr Thr Leu
     130                 135                 140                
 Asn Ile Cys Leu Val Ala Ala Ser Gly Thr Gln Asp Arg Ala Ala Pro
 145                 150                 155                 160
 Ser His Phe Leu Pro Pro Asn Leu Leu Tyr Ser Glu Gln Glu Lys Asp
                 165                 170                 175    
 Ser Leu Thr Pro Asp Leu Pro Pro Asn Ile Thr Leu Ser Trp Gln Gln
             180                 185                 190        
 Leu His Pro Val Pro Tyr Pro Ser Pro Thr Thr Phe Leu Lys Ile Lys
         195                 200                 205            
 Leu Pro Ser Pro Gly Leu Ser
     210                 215



      <210> 982
      <211> 272
      <212> PRT
      <213> Homo sapiens


      <400> 982
 Met Lys Thr Phe Ala Gly Phe Ser Phe Leu Phe Leu Trp Leu Gln Leu
   1               5                  10                  15    
 Asp Cys Met Ser Arg Gly Glu Asp Val Glu Gln Ser Leu Phe Leu Ser
              20                  25                  30        
 Val Arg Glu Gly Asp Ser Ser Val Ile Asn Cys Thr Tyr Thr Asp Ser
          35                  40                  45            
 Ser Ser Thr Tyr Leu Tyr Trp Tyr Lys Gln Glu Pro Gly Ala Gly Leu
      50                  55                  60                
 Gln Leu Leu Thr Tyr Ile Phe Ser Asn Met Asp Met Lys Gln Asp Gln
  65                  70                  75                  80
 Arg Leu Thr Val Leu Leu Asn Lys Lys Asp Lys His Leu Ser Leu Arg
                  85                  90                  95    
 Ile Ala Asp Thr Gln Thr Gly Asp Ser Ala Ile Tyr Phe Cys Ala Leu
             100                 105                 110        
 Asp Thr Gly Arg Arg Ala Leu Thr Phe Gly Ser Gly Thr Arg Leu Gln
         115                 120                 125            
 Val Gln Pro Asn Ile Gln Asn Pro Asp Pro Ala Val Tyr Gln Leu Arg
     130                 135                 140                
 Asp Ser Lys Ser Ser Asp Lys Ser Val Cys Leu Phe Thr Asp Phe Asp
 145                 150                 155                 160
 Ser Gln Thr Asn Val Ser Gln Ser Lys Asp Ser Asp Val Tyr Ile Thr
                 165                 170                 175    
 Asp Lys Thr Val Leu Asp Met Arg Ser Met Asp Phe Lys Ser Asn Ser
             180                 185                 190        
 Ala Val Ala Trp Ser Asn Lys Ser Asp Phe Ala Cys Ala Asn Ala Phe
         195                 200                 205            
 Asn Asn Ser Ile Ile Pro Glu Asp Thr Phe Phe Pro Ser Pro Glu Ser
     210                 215                 220                
 Ser Cys Asp Val Lys Leu Val Glu Lys Ser Phe Glu Thr Asp Thr Asn
 225                 230                 235                 240
 Leu Asn Phe Gln Asn Leu Ser Val Ile Gly Phe Arg Ile Leu Leu Leu
                 245                 250                 255    
 Lys Val Ala Gly Phe Asn Leu Leu Met Thr Leu Arg Leu Trp Ser Ser
             260                 265                 270        





      <210> 983
      <211> 356
      <212> PRT
      <213> Homo sapiens


      <400> 983
 Met Leu Val Leu Asn Cys Ser Thr Lys Leu Leu Ile Leu Glu Lys Thr
   1               5                  10                  15    
 Leu Lys Ser Cys Phe Pro Glu Ser Leu Lys Val Tyr Gly Ala Val Met
              20                  25                  30        
 Asn Ile Asn Arg Gly Asn Pro Phe Gln Lys Glu Val Val Leu Asp Ser
          35                  40                  45            
 Trp Pro Asp Phe Lys Ala Val Ile Thr Arg Arg Gln Arg Glu Ala Glu
      50                  55                  60                
 Thr Asp Asn Leu Asp His Tyr Thr Asn Ala Tyr Ala Val Phe Tyr Lys
  65                  70                  75                  80
 Asp Val Arg Ala Tyr Arg Gln Leu Leu Glu Glu Cys Asp Val Phe Asn
                  85                  90                  95    
 Trp Asp Gln Val Phe Gln Ile Gln Gly Leu Gln Ser Glu Leu Tyr Asp
             100                 105                 110        
 Val Ser Lys Ala Val Ala Asn Ser Lys Gln Leu Asn Ile Lys Leu Thr
         115                 120                 125            
 Ser Phe Lys Ala Val His Phe Ser Pro Val Ser Ser Leu Pro Asp Thr
     130                 135                 140                
 Ser Phe Leu Tyr Val Asn Gln Val Phe Ala Phe Gly Ala Gly Leu Thr
 145                 150                 155                 160
 Ala Ile Glu Val His Val Ala Val Thr Gly Thr Leu Ser Ala Gln Asp
                 165                 170                 175    
 Phe Ile Gly Ser Ile Leu Cys Leu Ala Gln Thr Asp Phe Leu Asp Ser
             180                 185                 190        
 Gln Lys Glu Ser Gln Cys Ser Ala Lys Pro Thr Leu Phe Ala Gln Leu
         195                 200                 205            
 Asn His Ser Glu Pro Phe Ile Lys Gly Pro Ser Pro Arg Leu Thr Tyr
     210                 215                 220                
 Leu Ser Val Ala Asn Ala Asp Leu Leu Asn Arg Thr Trp Ser Arg Gly
 225                 230                 235                 240
 Gly Asn Glu Gln Cys Leu Arg Tyr Ile Ala Asn Leu Ile Ser Cys Phe
                 245                 250                 255    
 Pro Ser Val Cys Val Arg Asp Glu Lys Gly Asn Pro Val Ser Trp Ser
             260                 265                 270        
 Ile Thr Asp Gln Phe Ala Thr Met Cys His Gly Tyr Thr Leu Pro Glu
         275                 280                 285            
 His Arg Arg Lys Gly Tyr Ser Arg Leu Val Ala Leu Thr Leu Ala Arg
     290                 295                 300                
 Lys Leu Gln Ser Arg Gly Phe Pro Ser Gln Gly Asn Val Leu Asp Asp
 305                 310                 315                 320
 Asn Thr Ala Ser Ile Ser Leu Leu Lys Ser Leu His Ala Glu Phe Leu
                 325                 330                 335    
 Pro Cys Arg Phe His Arg Leu Ile Leu Thr Pro Ala Thr Phe Ser Gly
             340                 345                 350        
 Leu Pro His Leu
         355    



      <210> 984
      <211> 89
      <212> PRT
      <213> Homo sapiens


      <400> 984
 Met Ala Arg Pro Gln Pro Val Leu Gln Leu Asn Cys Pro Thr Leu Ser
   1               5                  10                  15    
 Ser Ser Ala Glu Pro Pro Lys Ser Gln Met Val Ser Pro Leu Ile Ser
              20                  25                  30        
 Ala Leu Phe His Val Pro Phe Leu Trp Leu Gly Met Phe Phe Pro His
          35                  40                  45            
 Ser Leu Ser Gly Pro Phe Pro Ser His Leu Arg Arg Ala Ser Ser Ser
      50                  55                  60                
 Arg Lys Pro Leu Val Lys Pro Pro Arg Ala Arg Gln Tyr Pro Pro Leu
  65                  70                  75                  80
 Gly Phe Phe Gly Tyr Lys Arg Lys Ile
                  85                



      <210> 985
      <211> 263
      <212> PRT
      <213> Homo sapiens


      <400> 985
 Met Arg Leu Gly Leu Cys Val Val Ala Leu Val Leu Ser Trp Thr His
   1               5                  10                  15    
 Leu Thr Ile Ser Ser Arg Gly Ile Lys Gly Lys Arg Gln Arg Arg Ile
              20                  25                  30        
 Ser Ala Glu Gly Ser Gln Ala Cys Ala Lys Gly Cys Glu Leu Cys Ser
          35                  40                  45            
 Glu Val Asn Gly Cys Leu Lys Cys Ser Pro Lys Leu Phe Ile Leu Leu
      50                  55                  60                
 Glu Arg Asn Asp Ile Arg Gln Val Gly Val Cys Leu Pro Ser Cys Pro
  65                  70                  75                  80
 Pro Gly Tyr Phe Asp Ala Arg Asn Pro Asp Met Asn Lys Cys Ile Lys
                  85                  90                  95    
 Cys Lys Ile Glu His Cys Glu Ala Cys Phe Ser His Asn Phe Cys Thr
             100                 105                 110        
 Lys Cys Lys Glu Gly Leu Tyr Leu His Lys Gly Arg Cys Tyr Pro Ala
         115                 120                 125            
 Cys Pro Glu Gly Ser Ser Ala Ala Asn Gly Thr Met Glu Cys Ser Ser
     130                 135                 140                
 Pro Ala Gln Cys Glu Met Ser Glu Trp Ser Pro Trp Gly Pro Cys Ser
 145                 150                 155                 160
 Lys Lys Gln Gln Leu Cys Gly Phe Arg Arg Gly Ser Glu Glu Arg Thr
                 165                 170                 175    
 Arg Arg Val Leu His Ala Pro Val Gly Asp His Ala Ala Cys Ser Asp
             180                 185                 190        
 Thr Lys Glu Thr Arg Arg Cys Thr Val Arg Arg Val Pro Cys Pro Glu
         195                 200                 205            
 Gly Gln Lys Arg Arg Lys Gly Gly Gln Gly Arg Arg Glu Asn Ala Asn
     210                 215                 220                
 Arg Asn Leu Ala Arg Lys Glu Ser Lys Glu Ala Gly Ala Gly Ser Arg
 225                 230                 235                 240
 Arg Arg Lys Gly Gln Gln Gln Gln Gln Gln Gln Gly Thr Val Gly Pro
                 245                 250                 255    
 Leu Thr Ser Ala Gly Pro Ala
             260            



      <210> 986
      <211> 54
      <212> PRT
      <213> Homo sapiens


      <400> 986
 Met Cys Ser Ile Pro Arg His Leu Leu Pro Leu Val Leu Pro Val Ala
   1               5                  10                  15    
 Leu Leu Leu Cys Ala Leu Glu Pro Leu Lys His Arg Gly Leu Glu Arg
              20                  25                  30        
 Leu Ile Arg His Pro Gln His Leu Glu Arg Gly Leu Ala His Lys Thr
          35                  40                  45            
 Ala Met Asn Gly Gln Pro
      50                



      <210> 987
      <211> 444
      <212> PRT
      <213> Homo sapiens


      <400> 987
 Met Pro Leu Lys His Tyr Leu Leu Leu Leu Val Gly Cys Gln Ala Trp
   1               5                  10                  15    
 Gly Ala Gly Leu Ala Tyr His Gly Cys Pro Ser Glu Cys Thr Cys Ser
              20                  25                  30        
 Arg Ala Ser Gln Val Glu Cys Thr Gly Ala Arg Ile Val Ala Val Pro
          35                  40                  45            
 Thr Pro Leu Pro Trp Asn Ala Met Ser Leu Gln Ile Leu Asn Thr His
      50                  55                  60                
 Ile Thr Glu Leu Asn Glu Ser Pro Phe Leu Asn Ile Ser Ala Leu Ile
  65                  70                  75                  80
 Ala Leu Arg Ile Glu Lys Asn Glu Leu Ser Arg Ile Thr Pro Gly Ala
                  85                  90                  95    
 Phe Arg Asn Leu Gly Ser Leu Arg Tyr Leu Ser Leu Ala Asn Asn Lys
             100                 105                 110        
 Leu Gln Val Leu Pro Ile Gly Leu Phe Gln Gly Leu Asp Ser Leu Glu
         115                 120                 125            
 Ser Leu Leu Leu Ser Ser Asn Gln Leu Leu Gln Ile Gln Pro Ala His
     130                 135                 140                
 Phe Ser Gln Cys Ser Asn Leu Lys Glu Leu Gln Leu His Gly Asn His
 145                 150                 155                 160
 Leu Glu Tyr Ile Pro Asp Gly Ala Phe Asp His Leu Val Gly Leu Thr
                 165                 170                 175    
 Lys Leu Asn Leu Gly Lys Asn Ser Leu Thr His Ile Ser Pro Arg Val
             180                 185                 190        
 Phe Gln His Leu Gly Asn Leu Gln Val Leu Arg Leu Tyr Glu Asn Arg
         195                 200                 205            
 Leu Thr Asp Ile Pro Met Gly Thr Phe Asp Gly Leu Val Asn Leu Gln
     210                 215                 220                
 Glu Leu Ala Leu Gln Gln Asn Gln Ile Gly Leu Leu Ser Pro Gly Leu
 225                 230                 235                 240
 Phe His Asn Asn His Asn Leu Gln Arg Leu Tyr Leu Ser Asn Asn His
                 245                 250                 255    
 Ile Ser Gln Leu Pro Pro Ser Ile Phe Met Gln Leu Pro Gln Leu Asn
             260                 265                 270        
 Arg Leu Thr Leu Phe Gly Asn Ser Leu Lys Glu Leu Ser Leu Gly Ile
         275                 280                 285            
 Phe Gly Pro Met Pro Asn Leu Arg Glu Leu Trp Leu Tyr Asp Asn His
     290                 295                 300                
 Ile Ser Ser Leu Pro Asp Asn Val Phe Ser Asn Leu Arg Gln Leu Gln
 305                 310                 315                 320
 Val Leu Ile Leu Ser Arg Asn Gln Ile Ser Phe Ile Ser Pro Gly Ala
                 325                 330                 335    
 Phe Asn Gly Leu Thr Glu Leu Arg Glu Leu Ser Leu His Thr Asn Ala
             340                 345                 350        
 Leu Gln Asp Leu Asp Gly Asn Val Phe Arg Met Leu Ala Asn Leu Gln
         355                 360                 365            
 Thr Ser Pro Cys Arg Thr Ile Ala Ser Asp Ser Ser Gln Gly Ile Ser
     370                 375                 380                
 Ser Pro Thr Ser Met Ala Ser Trp Pro Ser Ser Cys Arg Thr Thr Ser
 385                 390                 395                 400
 Trp Arg Thr Cys Pro Ser Ala Ser Ser Ile Thr Trp Gly Asn Cys Val
                 405                 410                 415    
 Ser Cys Gly Cys Met Thr Ile Pro Gly Gly Val Thr Gln Thr Ser Phe
             420                 425                 430        
 Arg Ser Ala Thr Gly Ser Cys Ser Thr Ser Leu Gly
         435                 440                



      <210> 988
      <211> 359
      <212> PRT
      <213> Homo sapiens


      <400> 988
 Met Glu Ala Ala Ala Gly Val Trp Gly Trp Gly Cys Leu Phe Arg Val
   1               5                  10                  15    
 Pro Trp Arg Arg Pro Gln Ala Ala Ser Val Gly Leu Arg Thr Arg Leu
              20                  25                  30        
 His Ala Arg Phe Ser Gly Arg Leu Trp Thr Trp Glu Pro Leu Asn Val
          35                  40                  45            
 Pro Leu Arg Gly Gly Ser Glu Gly Gly Arg Phe Tyr Ala Ser Cys Val
      50                  55                  60                
 Glu Pro Leu Thr Cys Thr Leu Gln Gly Pro Val Gly Asp Gly Ala Ala
  65                  70                  75                  80
 Cys Trp Arg Gln Gly Ala Trp Pro Gln Arg Trp Arg Arg Glu Pro Gly
                  85                  90                  95    
 Asn Leu Ala Gly Val Arg His Ile Ile Leu Val Leu Ser Gly Lys Gly
             100                 105                 110        
 Gly Val Gly Lys Ser Thr Ile Ser Thr Glu Leu Ala Leu Ala Leu Arg
         115                 120                 125            
 His Ala Gly Lys Lys Val Gly Ile Leu Asp Val Asp Leu Cys Gly Pro
     130                 135                 140                
 Ser Ile Pro Arg Met Leu Gly Ala Gln Gly Arg Ala Val His Gln Cys
 145                 150                 155                 160
 Asp Arg Gly Trp Ala Pro Val Phe Leu Asp Arg Glu Gln Ser Ile Ser
                 165                 170                 175    
 Leu Met Ser Val Gly Phe Leu Leu Glu Lys Pro Asp Glu Ala Val Val
             180                 185                 190        
 Trp Arg Gly Pro Lys Lys Asn Ala Leu Ile Lys Gln Phe Val Ser Asp
         195                 200                 205            
 Val Ala Trp Gly Glu Leu Asp Tyr Leu Val Val Asp Thr Pro Pro Gly
     210                 215                 220                
 Thr Ser Asp Glu His Met Ala Thr Ile Glu Ala Leu Arg Pro Tyr Gln
 225                 230                 235                 240
 Pro Leu Gly Ala Leu Val Val Thr Thr Pro Gln Ala Val Ser Val Gly
                 245                 250                 255    
 Asp Val Arg Arg Glu Leu Thr Phe Cys Arg Lys Thr Gly Leu Arg Val
             260                 265                 270        
 Met Gly Ile Val Glu Asn Met Ser Gly Phe Thr Cys Pro His Cys Thr
         275                 280                 285            
 Glu Cys Thr Ser Val Phe Ser Arg Gly Gly Gly Glu Glu Leu Ala Gln
     290                 295                 300                
 Leu Ala Gly Val Pro Phe Leu Gly Ser Val Pro Leu Asp Pro Ala Leu
 305                 310                 315                 320
 Met Arg Thr Leu Glu Glu Gly His Asp Phe Ile Gln Glu Phe Pro Gly
                 325                 330                 335    
 Ser Pro Ala Phe Ala Ala Leu Thr Ser Ile Ala Gln Lys Ile Leu Asp
             340                 345                 350        
 Ala Thr Pro Ala Cys Leu Pro
         355                



      <210> 989
      <211> 685
      <212> PRT
      <213> Homo sapiens


      <400> 989
 Met Leu Trp Phe Ser Gly Val Gly Ala Leu Ala Glu Arg Tyr Cys Arg
   1               5                  10                  15    
 Arg Ser Pro Gly Ile Thr Cys Cys Val Leu Leu Leu Leu Asn Cys Ser
              20                  25                  30        
 Gly Val Pro Met Ser Leu Ala Ser Ser Phe Leu Thr Gly Ser Val Ala
          35                  40                  45            
 Lys Cys Glu Asn Glu Gly Glu Val Leu Gln Ile Pro Phe Ile Thr Asp
      50                  55                  60                
 Asn Pro Cys Ile Met Cys Val Cys Leu Asn Lys Glu Val Thr Cys Lys
  65                  70                  75                  80
 Arg Glu Lys Cys Pro Val Leu Ser Arg Asp Cys Ala Leu Ala Ile Lys
                  85                  90                  95    
 Gln Arg Gly Ala Cys Cys Glu Gln Cys Lys Gly Cys Thr Tyr Glu Gly
             100                 105                 110        
 Asn Thr Tyr Asn Ser Ser Phe Lys Trp Gln Ser Pro Ala Glu Pro Cys
         115                 120                 125            
 Val Leu Arg Gln Cys Gln Glu Gly Val Val Thr Glu Ser Gly Val Arg
     130                 135                 140                
 Cys Val Val His Cys Lys Asn Pro Leu Glu His Leu Gly Met Cys Cys
 145                 150                 155                 160
 Pro Thr Cys Pro Gly Cys Val Phe Glu Gly Val Gln Tyr Gln Glu Gly
                 165                 170                 175    
 Glu Glu Phe Gln Pro Glu Gly Ser Lys Cys Thr Lys Cys Ser Cys Thr
             180                 185                 190        
 Gly Gly Arg Thr Gln Cys Val Arg Glu Val Cys Pro Ile Leu Ser Cys
         195                 200                 205            
 Pro Gln His Leu Ser His Ile Pro Pro Gly Gln Cys Cys Pro Lys Cys
     210                 215                 220                
 Leu Gly Gln Arg Lys Val Phe Asp Leu Pro Phe Gly Ser Cys Leu Phe
 225                 230                 235                 240
 Arg Ser Asp Val Tyr Asp Asn Gly Ser Ser Phe Leu Tyr Asp Asn Cys
                 245                 250                 255    
 Thr Ala Cys Thr Cys Arg Asp Ser Thr Val Val Cys Lys Arg Lys Cys
             260                 265                 270        
 Ser His Pro Gly Gly Cys Asp Gln Gly Gln Glu Gly Cys Cys Glu Glu
         275                 280                 285            
 Cys Leu Leu Arg Val Pro Pro Glu Asp Ile Lys Val Cys Lys Phe Gly
     290                 295                 300                
 Asn Lys Ile Phe Gln Asp Gly Glu Met Trp Ser Ser Ile Asn Cys Thr
 305                 310                 315                 320
 Ile Cys Ala Cys Val Lys Gly Arg Thr Glu Cys Arg Asn Lys Gln Cys
                 325                 330                 335    
 Ile Pro Ile Ser Ser Cys Pro Gln Gly Lys Ile Leu Asn Arg Lys Gly
             340                 345                 350        
 Cys Cys Pro Ile Cys Thr Glu Lys Pro Gly Val Cys Thr Val Phe Gly
         355                 360                 365            
 Asp Pro His Tyr Asn Thr Phe Asp Gly Arg Thr Phe Asn Phe Gln Gly
     370                 375                 380                
 Thr Cys Gln Tyr Val Leu Thr Lys Asp Cys Ser Ser Pro Ala Ser Pro
 385                 390                 395                 400
 Phe Gln Val Leu Val Lys Asn Asp Ala Arg Arg Thr Arg Ser Phe Ser
                 405                 410                 415    
 Trp Thr Lys Ser Val Glu Leu Val Leu Gly Glu Ser Arg Val Ser Leu
             420                 425                 430        
 Gln Gln His Leu Thr Val Arg Trp Asn Gly Ser Arg Ile Ala Leu Pro
         435                 440                 445            
 Cys Arg Ala Pro His Phe His Ile Asp Leu Asp Gly Tyr Leu Leu Lys
     450                 455                 460                
 Val Thr Thr Lys Ala Gly Leu Glu Ile Ser Trp Asp Gly Asp Ser Phe
 465                 470                 475                 480
 Val Glu Val Met Ala Ala Pro His Leu Lys Gly Lys Leu Cys Gly Leu
                 485                 490                 495    
 Cys Gly Asn Tyr Asn Gly His Lys Arg Asp Asp Leu Ile Gly Gly Asp
             500                 505                 510        
 Gly Asn Phe Lys Phe Asp Val Asp Asp Phe Ala Glu Ser Trp Arg Val
         515                 520                 525            
 Glu Ser Asn Glu Phe Cys Asn Arg Pro Gln Arg Lys Pro Val Pro Glu
     530                 535                 540                
 Leu Cys Gln Gly Thr Val Lys Val Lys Leu Arg Ala His Arg Glu Cys
 545                 550                 555                 560
 Gln Lys Leu Lys Ser Trp Glu Phe Gln Thr Cys His Ser Thr Val Asp
                 565                 570                 575    
 Tyr Ala Thr Phe Tyr Arg Ser Cys Val Thr Asp Met Cys Glu Cys Pro
             580                 585                 590        
 Val His Lys Asn Cys Tyr Cys Glu Ser Phe Leu Ala Tyr Thr Arg Ala
         595                 600                 605            
 Cys Gln Arg Glu Gly Ile Lys Val His Trp Glu Pro Gln Gln Asn Cys
     610                 615                 620                
 Ala Ala Thr Gln Cys Lys His Gly Ala Val Tyr Asp Thr Cys Gly Pro
 625                 630                 635                 640
 Gly Cys Ile Lys Thr Cys Asp Asn Trp Asn Glu Ile Gly Pro Cys Asn
                 645                 650                 655    
 Lys Pro Cys Val Ala Gly Cys His Cys Pro Ala Asn Leu Val Leu His
             660                 665                 670        
 Lys Gly Arg Cys Ile Lys Pro Val Leu Cys Pro Gln Arg
         675                 680                 685



      <210> 990
      <211> 324
      <212> PRT
      <213> Homo sapiens


      <400> 990
 Met Gln Leu Pro Leu Ala Leu Cys Leu Val Cys Leu Leu Val His Thr
   1               5                  10                  15    
 Ala Phe Arg Val Val Glu Gly Gln Gly Trp Gln Ala Phe Lys Asn Asp
              20                  25                  30        
 Ala Thr Glu Ile Ile Pro Glu Leu Gly Glu Tyr Pro Glu Pro Pro Pro
          35                  40                  45            
 Glu Leu Glu Asn Asn Lys Thr Met Asn Arg Ala Glu Asn Gly Gly Arg
      50                  55                  60                
 Pro Pro His His Pro Phe Glu Thr Lys Ala Leu Val Glu Glu Gln Ser
  65                  70                  75                  80
 Cys Leu Glu Val Gly Glu Glu Trp Leu Ala Gly Ala Ala Phe Lys Phe
                  85                  90                  95    
 Arg Cys Arg Gly Met Arg Gln Gln Thr Leu Val Arg Ala Gln Gly Arg
             100                 105                 110        
 Glu Asp Ala Gly Val Val Arg Val Trp His Gln Gly Ile Arg Thr Gly
         115                 120                 125            
 Ser Gly Ala Gln Lys Arg Lys Gly Phe Lys Glu Ser Pro Pro Gly Asn
     130                 135                 140                
 Ile Gly Ala Thr Ser Ser Cys Trp Tyr His Trp Glu Gly Asn Lys Val
 145                 150                 155                 160
 Ala Glu Lys Ser Thr Ala Gln Ala Pro Gly Pro Gln Pro Ser Pro Pro
                 165                 170                 175    
 His Asn Leu Leu Gly Leu Trp Gly Ala Lys Lys Gly Asn Cys Met Gly
             180                 185                 190        
 Gly Gln Pro Gly Pro Ser Val Phe Lys Met Glu Asp Lys Gly Ala Ser
         195                 200                 205            
 Pro His Ser Ser Pro Ser Arg Gln Gly Gln Leu Gly Ser Ser Asp Cys
     210                 215                 220                
 Leu Lys Gly Tyr Val Ser Glu Tyr Ser Cys Arg Glu Leu His Phe Thr
 225                 230                 235                 240
 Arg Tyr Val Thr Asp Gly Pro Cys Arg Ser Ala Lys Pro Val Thr Glu
                 245                 250                 255    
 Leu Val Cys Ser Gly Gln Cys Gly Pro Ala Arg Leu Leu Pro Asn Ala
             260                 265                 270        
 Ile Gly Arg Gly Lys Trp Trp Arg Pro Ser Gly Pro Asp Phe Arg Cys
         275                 280                 285            
 Ile Pro Asp Arg Tyr Arg Arg Val Gln Leu Leu Cys Pro Gly Glu Gly
     290                 295                 300                
 Arg Lys Arg Gly Pro Ala Arg Ser Ala Lys Ala Asn Gln Ala Glu Leu
 305                 310                 315                 320
 Glu Asn Ala Tyr
                



      <210> 991
      <211> 79
      <212> PRT
      <213> Homo sapiens


      <400> 991
 Met Lys Gly Asn Ser Glu Gln Cys Leu Leu Leu Cys Thr Leu Gly Arg
   1               5                  10                  15    
 Thr Val Val Ala Thr Leu Tyr Thr Arg Thr Asn Cys Gly Cys Cys Leu
              20                  25                  30        
 Gln Gly Asp Glu Gln Leu Ile Cys Ile Glu Arg Leu Leu Arg Gln Val
          35                  40                  45            
 Ala Cys Leu Leu Asn Glu Leu Cys Thr Asp Leu Arg Glu Asp Leu Asn
      50                  55                  60                
 Ser Tyr Arg Ser Cys Gly Asp Leu Ile Ile His Ser His Ile Val
  65                  70                  75                



      <210> 992
      <211> 222
      <212> PRT
      <213> Homo sapiens


      <400> 992
 Met Ala Trp Ala Leu Leu Leu Leu Ser Leu Leu Thr Gln Gly Thr Gly
   1               5                  10                  15    
 Ser Trp Ala Gln Ser Ala Leu Thr Gln Pro Pro Ser Ala Ser Gly Ser
              20                  25                  30        
 Pro Gly Gln Ser Val Thr Ile Ser Cys Thr Gly Thr Ser Ser Asp Val
          35                  40                  45            
 Gly Gly Tyr Asn Tyr Val Ser Trp Tyr Gln Gln His Pro Gly Lys Ala
      50                  55                  60                
 Pro Lys Leu Met Ile Tyr Glu Val Ser Lys Arg Pro Ser Gly Val Pro
  65                  70                  75                  80
 Asp Arg Phe Ser Gly Ser Lys Ser Gly Asn Thr Ala Ser Leu Thr Val
                  85                  90                  95    
 Ser Gly Leu Gln Ala Glu Asp Glu Ala Asp Tyr Tyr Cys Ser Ser Tyr
             100                 105                 110        
 Ala Gly Ser Asn Asn Phe Val Phe Gly Thr Gly Thr Lys Val Thr Val
         115                 120                 125            
 Leu Gly Gln Pro Lys Ala Asn Pro Thr Val Thr Leu Phe Pro Pro Ser
     130                 135                 140                
 Ser Glu Glu Leu Gln Ala Asn Lys Ala Thr Leu Val Cys Leu Ile Ser
 145                 150                 155                 160
 Asp Phe Tyr Pro Gly Ala Val Thr Val Ala Trp His Arg Gln Met Ala
                 165                 170                 175    
 Ala Pro Ser Arg Arg Gly Val Glu Thr Thr Lys Ala Ser Lys Gln Ser
             180                 185                 190        
 Lys Arg Ala Ser Thr Arg Pro Ala Asp Tyr Leu Ser Leu Thr Pro Glu
         195                 200                 205            
 Gln Gly Lys Ser His Arg Ser Tyr Ser Leu Gln Val Thr Ala
     210                 215                 220        



      <210> 993
      <211> 126
      <212> PRT
      <213> Homo sapiens


      <400> 993
 Met Arg Lys Met Gly Gln Phe Thr Ala Ala Met Val Gly Arg Ile Ser
   1               5                  10                  15    
 Cys Leu Gly Val Trp Lys Leu Pro Arg Val Glu Ser Cys Ser Gln Pro
              20                  25                  30        
 Ala Arg Pro Leu Leu Ser Leu Ala Gln Thr Thr Thr Lys Thr Thr Ala
          35                  40                  45            
 Thr Thr Thr Thr Thr Thr Lys His Ala Thr Cys Ala Leu Ala Tyr Thr
      50                  55                  60                
 Asn Thr Pro Thr Glu Pro Asn Gln Ala Asp Lys Ala Ser Arg Arg Ala
  65                  70                  75                  80
 Ser Gly Arg Leu Ile Pro Ala Ala Arg His Ile Pro Trp His Gly Ala
                  85                  90                  95    
 Thr Ala Ala Gln Leu Pro Ala Pro Pro Pro Ser Val Ile Ser Ala Leu
             100                 105                 110        
 Pro Thr Val Ser Val Pro Thr Gln Tyr Thr Glu Ala Asn Lys
         115                 120                 125    



      <210> 994
      <211> 338
      <212> PRT
      <213> Homo sapiens


      <400> 994
 Met Tyr His Pro Ala Tyr Trp Val Val Phe Ser Ala Thr Thr Ala Leu
   1               5                  10                  15    
 Leu Phe Ile Pro Gly Val Pro Val Arg Ser Gly Asp Ala Thr Phe Pro
              20                  25                  30        
 Lys Ala Met Asp Asn Val Thr Val Arg Gln Gly Glu Ser Ala Thr Leu
          35                  40                  45            
 Arg Cys Thr Ile Asp Asp Arg Val Thr Arg Val Ala Trp Leu Asn Arg
      50                  55                  60                
 Ser Thr Ile Leu Tyr Ala Gly Asn Asp Lys Trp Ser Ile Asp Pro Arg
  65                  70                  75                  80
 Val Ile Ile Leu Val Asn Thr Pro Thr Gln Tyr Ser Ile Met Ile Gln
                  85                  90                  95    
 Asn Val Asp Val Tyr Asp Glu Gly Pro Tyr Thr Cys Ser Val Gln Thr
             100                 105                 110        
 Asp Asn His Pro Lys Thr Ser Arg Val His Leu Ile Val Gln Val Pro
         115                 120                 125            
 Pro Gln Ile Met Asn Ile Ser Ser Asp Ile Thr Val Asn Glu Gly Ser
     130                 135                 140                
 Ser Val Thr Leu Leu Cys Leu Ala Ile Gly Arg Pro Glu Pro Thr Val
 145                 150                 155                 160
 Thr Trp Arg His Leu Ser Val Lys Glu Gly Gln Gly Phe Val Ser Glu
                 165                 170                 175    
 Asp Glu Tyr Leu Glu Ile Ser Asp Ile Lys Arg Asp Gln Ser Gly Glu
             180                 185                 190        
 Tyr Glu Cys Ser Ala Leu Asn Asp Val Ala Ala Pro Asp Val Arg Lys
         195                 200                 205            
 Val Lys Ile Thr Val Asn Tyr Pro Pro Tyr Ile Ser Lys Ala Lys Asn
     210                 215                 220                
 Thr Gly Val Ser Val Gly Gln Lys Gly Ile Leu Ser Cys Glu Ala Ser
 225                 230                 235                 240
 Ala Val Pro Met Ala Glu Phe Gln Trp Phe Lys Glu Glu Thr Arg Leu
                 245                 250                 255    
 Ala Thr Gly Leu Asp Gly Met Arg Ile Glu Asn Lys Gly Arg Met Ser
             260                 265                 270        
 Thr Leu Thr Phe Phe Asn Val Ser Glu Lys Asp Tyr Gly Asn Tyr Thr
         275                 280                 285            
 Cys Val Ala Thr Asn Lys Leu Gly Asn Thr Asn Ala Ser Ile Thr Leu
     290                 295                 300                
 Tyr Gly Pro Gly Ala Val Ile Asp Gly Val Asn Ser Ala Ser Arg Ala
 305                 310                 315                 320
 Leu Ala Cys Leu Trp Leu Ser Gly Thr Leu Leu Ala His Phe Phe Ile
                 325                 330                 335    
 Lys Phe
        



      <210> 995
      <211> 506
      <212> PRT
      <213> Homo sapiens


      <400> 995
 Met His Gly Ser Cys Ser Phe Leu Met Leu Leu Leu Pro Leu Leu Leu
   1               5                  10                  15    
 Leu Leu Val Ala Thr Thr Gly Pro Val Gly Ala Leu Thr Asp Glu Glu
              20                  25                  30        
 Lys Arg Leu Met Val Glu Leu His Asn Leu Tyr Arg Ala Gln Val Ser
          35                  40                  45            
 Pro Thr Ala Ser Asp Met Leu His Met Arg Trp Asp Glu Glu Leu Ala
      50                  55                  60                
 Ala Phe Ala Lys Ala Tyr Ala Arg Gln Cys Val Trp Gly His Asn Lys
  65                  70                  75                  80
 Glu Arg Gly Arg Arg Gly Glu Asn Leu Phe Ala Ile Thr Asp Glu Gly
                  85                  90                  95    
 Met Asp Val Pro Leu Ala Met Glu Glu Trp His His Glu Arg Glu His
             100                 105                 110        
 Tyr Asn Leu Ser Ala Ala Thr Cys Ser Pro Gly Gln Met Cys Gly His
         115                 120                 125            
 Tyr Thr Gln Val Val Trp Ala Lys Thr Glu Arg Ile Gly Cys Gly Ser
     130                 135                 140                
 His Phe Cys Glu Lys Leu Gln Gly Val Glu Glu Thr Asn Ile Glu Leu
 145                 150                 155                 160
 Leu Val Cys Asn Tyr Glu Pro Pro Gly Asn Val Lys Gly Lys Arg Pro
                 165                 170                 175    
 Tyr Gln Glu Gly Thr Pro Cys Ser Gln Cys Pro Ser Gly Tyr His Cys
             180                 185                 190        
 Lys Asn Ser Leu Cys Gly Glu Ser Thr Gly Gly Trp Pro Pro Thr Arg
         195                 200                 205            
 Ser His Phe Gly Ala Leu Ser Phe Gln Val Ala Gly Phe Gln Pro Phe
     210                 215                 220                
 Lys Gly Arg Met Leu Glu Ser Leu Ala Ala Ser Gly Gly Pro Ala Arg
 225                 230                 235                 240
 Glu Pro Ile Gly Ser Pro Glu Asp Ala Gln Asp Leu Pro Tyr Leu Val
                 245                 250                 255    
 Thr Glu Ala Pro Ser Phe Arg Ala Thr Glu Ala Ser Asp Ser Arg Lys
             260                 265                 270        
 Met Gly Thr Pro Ser Ser Leu Ala Thr Gly Ile Pro Ala Phe Leu Val
         275                 280                 285            
 Thr Glu Val Ser Gly Ser Leu Ala Thr Lys Ala Leu Pro Ala Val Glu
     290                 295                 300                
 Thr Gln Ala Pro Thr Ser Leu Ala Thr Lys Asp Pro Pro Ser Met Ala
 305                 310                 315                 320
 Thr Glu Ala Pro Pro Cys Val Thr Thr Glu Val Pro Ser Ile Leu Ala
                 325                 330                 335    
 Ala His Ser Leu Pro Ser Leu Asp Glu Glu Pro Val Thr Phe Pro Lys
             340                 345                 350        
 Ser Thr His Val Pro Ile Pro Lys Ser Ala Asp Lys Val Thr Asp Lys
         355                 360                 365            
 Thr Lys Val Pro Ser Arg Ser Pro Glu Asn Ser Leu Asp Pro Lys Met
     370                 375                 380                
 Ser Leu Thr Gly Ala Arg Glu Leu Leu Pro His Ala Gln Glu Glu Ala
 385                 390                 395                 400
 Glu Ala Glu Ala Glu Leu Pro Pro Ser Ser Glu Val Leu Ala Ser Val
                 405                 410                 415    
 Phe Pro Ala Gln Asp Lys Pro Gly Glu Leu Gln Ala Thr Leu Asp His
             420                 425                 430        
 Thr Gly His Thr Ser Ser Lys Ser Leu Pro Asn Phe Pro Asn Thr Ser
         435                 440                 445            
 Ala Thr Ala Asn Ala Thr Gly Gly Arg Ala Leu Ala Leu Gln Ser Ser
     450                 455                 460                
 Leu Pro Gly Ala Glu Gly Pro Asp Lys Pro Ser Val Val Ser Gly Leu
 465                 470                 475                 480
 Asn Ser Gly Pro Gly His Val Trp Gly Pro Leu Leu Gly Leu Leu Leu
                 485                 490                 495    
 Leu Pro Pro Leu Val Leu Ala Gly Ile Phe
             500                 505    



      <210> 996
      <211> 547
      <212> PRT
      <213> Homo sapiens


      <400> 996
 Met Ser Pro Ser Thr Gln Trp His Pro Leu Ala Thr Phe Phe Leu Ser
   1               5                  10                  15    
 Val Pro His Leu Met Pro Val His Leu His Pro Ser Ala Ala Ala Ala
              20                  25                  30        
 Val Arg Ser Ile Met Trp Pro Leu Thr Ala Leu Leu Leu Leu Val Pro
          35                  40                  45            
 Ser Ser Gly Gln Ala Ala Thr Leu Glu Lys Pro Ile Leu Ser Leu His
      50                  55                  60                
 Pro Pro Trp Thr Thr Ile Phe Lys Gly Glu Arg Val Thr Leu Lys Cys
  65                  70                  75                  80
 Asp Gly Tyr His Pro Leu Leu Leu Glu Leu Gln Pro Ile Ser Thr Leu
                  85                  90                  95    
 Trp Tyr Leu Gly His Leu Leu Leu Pro Ser His Lys Lys Ser Ile Glu
             100                 105                 110        
 Val Gln Thr Pro Gly Val Tyr Arg Cys Gln Thr Arg Gly Ala Pro Val
         115                 120                 125            
 Ser Asp Pro Ile His Leu Ser Val Ser Asn Asp Trp Leu Ile Leu Gln
     130                 135                 140                
 Val Pro Tyr Ala Pro Val Phe Glu Gly Glu Pro Leu Val Leu Arg Cys
 145                 150                 155                 160
 Arg Gly Trp Tyr Asp Lys Val Val Tyr Lys Leu His Tyr Tyr His Asp
                 165                 170                 175    
 Gly Gln Ala Val Arg Tyr Phe His Ser Ser Ala Asn Tyr Thr Val Leu
             180                 185                 190        
 Gln Ala Arg Ala Ser Asp Ser Gly Arg Tyr Gln Cys Ser Gly Thr Met
         195                 200                 205            
 Arg Ile Pro Val Glu Ser Ala Pro Met Phe Ser Ala Lys Val Ala Val
     210                 215                 220                
 Thr Val Gln Ala Phe Pro Val Pro Arg Gly Leu Gly Pro Pro Ala Pro
 225                 230                 235                 240
 His Phe Arg Arg Leu Pro Phe Pro Leu His Val Asp Thr Arg Pro Pro
                 245                 250                 255    
 Pro Leu Pro Pro Trp Ser Val Gly Leu Gln Gly Ala Leu Ala Gly Ser
             260                 265                 270        
 Arg Lys Glu Arg Gly Arg Gly Ala Val Asp Lys Pro Ala Pro Leu Leu
         275                 280                 285            
 Pro Ala Leu Ser Val Glu Leu Phe Arg Ala Pro Val Leu Arg Val Met
     290                 295                 300                
 Gly Pro Arg Glu Ala Arg Gly Ala Ala Leu Gly Gly Val Val Leu Arg
 305                 310                 315                 320
 Cys Asp Thr Arg Leu His Pro Gln Lys Arg Asp Thr Pro Leu Gln Phe
                 325                 330                 335    
 Ala Phe Tyr Lys Tyr Ser Arg Ala Val Arg Arg Phe Asp Trp Gly Ala
             340                 345                 350        
 Glu Tyr Thr Val Pro Glu Pro Glu Val Glu Glu Leu Glu Ser Tyr Trp
         355                 360                 365            
 Cys Glu Ala Ala Thr Ala Thr Arg Ser Val Arg Lys Arg Ser Pro Trp
     370                 375                 380                
 Leu Gln Leu Pro Gly Pro Ala Gln Arg Arg Glu Glu Pro Cys Lys Pro
 385                 390                 395                 400
 Arg Val Thr Gly Arg Asn Ala Phe Thr Gly Ser Pro Leu Asp Pro Ala
                 405                 410                 415    
 Ser Thr Thr Ala Pro Ala Pro Trp Ala Ala Ala Leu Ala Pro Gly Asn
             420                 425                 430        
 Arg Pro Leu Ser Phe Arg Lys Pro Pro Val Ser Arg Ser Val Pro Leu
         435                 440                 445            
 Val Thr Ser Val Arg Asn Thr Thr Ser Thr Gly Leu Gln Phe Pro Ala
     450                 455                 460                
 Ser Gly Ala Pro Thr Ala Gly Pro Pro Ala Cys Ala Pro Pro Thr Pro
 465                 470                 475                 480
 Leu Glu Gln Ser Ala Gly Ala Leu Lys Pro Asp Val Asp Leu Leu Leu
                 485                 490                 495    
 Arg Glu Met Gln Leu Leu Lys Gly Leu Leu Ser Arg Val Val Leu Glu
             500                 505                 510        
 Leu Lys Glu Pro Gln Ala Leu Arg Glu Leu Arg Gly Thr Pro Glu Thr
         515                 520                 525            
 Pro Thr Ser His Phe Ala Val Ser Pro Gly Thr Pro Glu Thr Thr Pro
     530                 535                 540                
 Val Glu Ser
 545        



      <210> 997
      <211> 106
      <212> PRT
      <213> Homo sapiens


      <400> 997
 Met Glu Gln Cys Leu Ala Pro Arg Lys Pro Ser Gly Asn Ala Ile Ser
   1               5                  10                  15    
 Ser Leu Leu Ile Ile Leu Thr Arg Thr Leu Pro Leu Val Ala Ile His
              20                  25                  30        
 Glu Pro Ala Thr Asn Ser Asn Lys Val Leu Asp Ala Pro Phe Val Leu
          35                  40                  45            
 Ile Phe Val Leu Asn Val Pro Glu Gly His Leu Gly Lys Arg Met Gln
      50                  55                  60                
 Val Phe Lys Ser His Gln Leu Gln Ile Met Ala Thr Pro Cys Pro Ala
  65                  70                  75                  80
 Leu Arg Met Glu Ala Lys Thr Ile Pro Ser Glu Ile Val Phe Pro Cys
                  85                  90                  95    
 Gln Asp Gly Asp Cys Val Val Ala Leu Leu
             100                 105    



      <210> 998
      <211> 76
      <212> PRT
      <213> Homo sapiens


      <400> 998
 Met Val Cys Ile Pro Cys Ile Val Ile Pro Val Leu Leu Trp Ile Tyr
   1               5                  10                  15    
 Lys Lys Phe Leu Glu Pro Tyr Ile Tyr Pro Leu Val Ser Pro Phe Val
              20                  25                  30        
 Ser Arg Ile Trp Pro Lys Lys Ala Ile Gln Glu Ser Asn Asp Thr Asn
          35                  40                  45            
 Lys Gly Lys Val Asn Phe Lys Gly Ala Asp Met Asn Gly Leu Pro Thr
      50                  55                  60                
 Lys Gly Pro Thr Glu Ile Cys Asp Lys Lys Lys Asp
  65                  70                  75    



      <210> 999
      <211> 476
      <212> PRT
      <213> Homo sapiens


      <400> 999
 Met Ala Ala Cys Arg Tyr Cys Cys Ser Cys Leu Arg Leu Arg Pro Leu
   1               5                  10                  15    
 Ser Asp Gly Pro Phe Leu Leu Pro Arg Arg Asp Arg Ala Leu Thr Gln
              20                  25                  30        
 Leu Gln Val Arg Ala Leu Trp Ser Ser Ala Gly Ser Arg Ala Val Ala
          35                  40                  45            
 Val Asp Leu Gly Asn Arg Asn Leu Pro Ala Leu Phe Phe Met Phe Lys
      50                  55                  60                
 Ser Gly Asp Thr Ala Val Met Val Thr Ala Val Ser Lys Thr Lys Pro
  65                  70                  75                  80
 Ser Pro Ser Gln Phe Met Pro Leu Val Val Asp Tyr Arg Gln Lys Ala
                  85                  90                  95    
 Ala Ala Val Gly Met Thr Asp Gly Glu Cys Val Val Asn Pro Thr Arg
             100                 105                 110        
 Lys Glu Met Ser Ser Ser Thr Leu Asn Val Val Val Ala Gly Ala Pro
         115                 120                 125            
 Lys Ser Gln Thr Val Met Leu Glu Ala Ser Ala Glu Asn Ile Leu Gln
     130                 135                 140                
 Gln Asp Phe Cys His Ala Ile Lys Val Gly Val Lys Tyr Thr Gln Gln
 145                 150                 155                 160
 Ile Ile Gln Gly Ile Gln Gln Leu Val Lys Glu Ile Gly Val Thr Lys
                 165                 170                 175    
 Arg Thr Pro Gln Lys Leu Phe Thr Pro Ser Gln Glu Ile Val Lys His
             180                 185                 190        
 Ala His Lys Leu Thr Met Glu Arg Leu Tyr Ala Val Phe Thr Asp Tyr
         195                 200                 205            
 Glu His Asp Lys Ile Ser Arg Asp Glu Ala Val Asn Lys Ile Arg Leu
     210                 215                 220                
 Asp Thr Glu Glu Gln Leu Lys Glu Ile Phe Pro Glu Val Asp Leu Tyr
 225                 230                 235                 240
 Glu Ile Ile Glu Ser Phe Asn Thr Val Ala Lys Glu Val Phe Arg Ser
                 245                 250                 255    
 Ile Ile Leu Asn Glu Tyr Lys Arg Cys Asp Gly Arg Asp Leu Thr Leu
             260                 265                 270        
 Leu Arg Asn Ile Ser Cys Glu Val Asp Met Phe Lys Thr Leu His Gly
         275                 280                 285            
 Ser Glu Leu Phe Gln Arg Gly Gln Thr Gln Leu Leu Cys Ala Val Thr
     290                 295                 300                
 Phe Asp Ser Leu Glu Ser Ser Ile Lys Leu Asp Arg Val Ile Thr Thr
 305                 310                 315                 320
 Ile Asn Gly Ile Lys Asp Lys Asn Phe Met Leu His Tyr Glu Phe Pro
                 325                 330                 335    
 Pro Tyr Ala Thr Asn Glu Ile Val Lys Val Thr Gly Ile Asn Arg Arg
             340                 345                 350        
 Glu Leu Gly Pro Gly Ala Leu Ala Glu Lys Ala Leu Tyr Pro Val Ile
         355                 360                 365            
 Pro Lys Asp Phe Pro Phe Ala Ile Arg Val Thr Ser Glu Val Leu Glu
     370                 375                 380                
 Ser Asn Gly Ser Ser Ser Met Ala Ser Ala Cys Gly Val Ala Met Gly
 385                 390                 395                 400
 Leu Ala Thr Lys Thr Asp Leu Glu Lys Gly Glu Ile Glu Asp Tyr His
                 405                 410                 415    
 Leu Leu Thr Asp Ile Leu Gly Ile Glu Ala Tyr Asn Gly Asp Met Asp
             420                 425                 430        
 Phe Lys Ile Ala Gly Thr Asn Lys Gly Ile Thr Ala Leu Gln Ala Asp
         435                 440                 445            
 Ile Lys Leu Pro Gly Ile Thr Met Lys Ile Val Met Glu Ala Ile Gln
     450                 455                 460                
 Gln Ala Ser Val Ala Lys Arg Arg Phe Tyr Arg Ser
 465                 470                 475    



      <210> 1000
      <211> 119
      <212> PRT
      <213> Homo sapiens


      <400> 1000
 Met Ala Arg Ser Val Thr Leu Val Phe Leu Val Leu Val Ser Leu Thr
   1               5                  10                  15    
 Gly Leu Tyr Ala Ile Gln Lys Thr Pro Gln Ile Gln Val Tyr Ser Arg
              20                  25                  30        
 His Pro Pro Glu Asn Gly Lys Pro Asn Ile Leu Asn Cys Tyr Val Thr
          35                  40                  45            
 Gln Phe His Pro Pro His Ile Glu Ile Gln Met Leu Lys Asn Gly Lys
      50                  55                  60                
 Lys Ile Pro Lys Val Glu Met Ser Asp Met Ser Phe Asp Lys Asp Trp
  65                  70                  75                  80
 Ala Phe Leu Phe Leu Ala His Thr Glu Phe Thr Pro Thr Glu Thr Asp
                  85                  90                  95    
 Thr Tyr Ala Cys Arg Val Lys His Ala Ser Met Ala Glu Pro Lys Thr
             100                 105                 110        
 Val Tyr Trp Asp Arg Asp Met
         115                



      <210> 1001
      <211> 143
      <212> PRT
      <213> Homo sapiens


      <400> 1001
 Met Thr Val Glu Leu Trp Leu Arg Leu Arg Gly Lys Gly Leu Ala Met
   1               5                  10                  15    
 Leu His Val Thr Arg Gly Val Trp Gly Ser Arg Val Arg Val Trp Pro
              20                  25                  30        
 Leu Leu Pro Ala Leu Leu Gly Pro Pro Arg Ala Leu Ser Ser Leu Ala
          35                  40                  45            
 Ala Lys Met Gly Glu Tyr Arg Lys Met Trp Asn Pro Arg Glu Pro Arg
      50                  55                  60                
 Asp Trp Ala Gln Gln Tyr Arg Glu Arg Phe Ile Pro Phe Ser Lys Glu
  65                  70                  75                  80
 Gln Leu Leu Arg Leu Leu Ile Gln Val Thr Gly Ile Pro Leu Glu Ser
                  85                  90                  95    
 Gly Arg Glu Gly Gly Phe Gly Gly Val Leu Gly Pro Arg Gly Leu Leu
             100                 105                 110        
 His Pro Val Pro Leu Pro Pro Asn Pro Gly Pro Ala Ala Gly Glu Asp
         115                 120                 125            
 Gly Ala Leu Pro Ala Leu Trp Cys Leu Phe Glu His Pro Leu Ile
     130                 135                 140            



      <210> 1002
      <211> 376
      <212> PRT
      <213> Homo sapiens


      <400> 1002
 Met Ala Ala Leu Gly Asp Ile Gln Glu Ser Pro Ser Val Pro Ser Pro
   1               5                  10                  15    
 Val Ser Leu Ser Ser Pro Gly Thr Pro Gly Thr Gln His His Glu Pro
              20                  25                  30        
 Gln Leu His Leu His Gly His Gln His Gly Ser Pro Gly Ser Ser Pro
          35                  40                  45            
 Lys Val Leu Ser Gln Pro Ser Asp Leu Asp Leu Gln Asp Val Glu Glu
      50                  55                  60                
 Val Glu Ile Gly Arg Asp Thr Phe Trp Pro Asp Ser Glu Pro Lys Pro
  65                  70                  75                  80
 Glu Gln Ala Pro Arg Ser Pro Gly Ser Gln Ala Pro Asp Glu Gly Ala
                  85                  90                  95    
 Gly Gly Ala Leu Arg Ser Leu Leu Arg Ser Leu Pro Arg Arg Ala Arg
             100                 105                 110        
 Cys Ser Ala Gly Phe Gly Pro Glu Ser Ser Ala Glu Arg Pro Ala Gly
         115                 120                 125            
 Gln Pro Pro Gly Ala Val Pro Cys Ala Gln Pro Arg Gly Ala Trp Arg
     130                 135                 140                
 Val Thr Leu Val Gln Gln Ala Ala Ala Gly Pro Glu Gly Ala Pro Glu
 145                 150                 155                 160
 Arg Ala Ala Glu Leu Gly Val Asn Phe Gly Arg Ser Arg Gln Gly Ser
                 165                 170                 175    
 Ala Arg Gly Ala Lys Pro His Arg Cys Glu Ala Cys Gly Lys Ser Phe
             180                 185                 190        
 Lys Tyr Asn Ser Leu Leu Leu Lys His Gln Arg Ile His Thr Gly Glu
         195                 200                 205            
 Lys Pro Tyr Ala Cys His Glu Cys Gly Lys Arg Phe Arg Gly Trp Ser
     210                 215                 220                
 Gly Phe Ile Gln His His Arg Ile His Thr Gly Glu Lys Pro Tyr Glu
 225                 230                 235                 240
 Cys Gly Gln Cys Gly Arg Ala Phe Ser His Ser Ser His Phe Thr Gln
                 245                 250                 255    
 His Leu Arg Ile His Asn Gly Glu Lys Pro Tyr Lys Cys Gly Glu Cys
             260                 265                 270        
 Gly Gln Ala Phe Ser Gln Ser Ser Asn Leu Val Arg His Gln Arg Leu
         275                 280                 285            
 His Thr Gly Glu Lys Pro Tyr Ala Cys Ser Gln Cys Gly Lys Ala Phe
     290                 295                 300                
 Ile Trp Ser Ser Val Leu Ile Glu His Gln Arg Ile His Thr Gly Glu
 305                 310                 315                 320
 Lys Pro Tyr Glu Cys Ser Asp Cys Gly Lys Ala Phe Arg Gly Arg Ser
                 325                 330                 335    
 His Phe Phe Arg His Leu Arg Thr His Thr Gly Glu Lys Pro Phe Ala
             340                 345                 350        
 Cys Gly Ala Cys Gly Lys Ala Phe Gly Gln Ser Ser Gln Leu Ile Gln
         355                 360                 365            
 His Gln Arg Val His Tyr Arg Glu
     370                 375    



      <210> 1003
      <211> 713
      <212> PRT
      <213> Homo sapiens


      <400> 1003
 Met Gly Glu Cys Ile Leu Leu Leu Pro Gln Cys Thr Thr Thr Asn Val
   1               5                  10                  15    
 Val Ala Tyr Asp Asn Ser His Gln Phe Ser His Asp Ser Gly Pro Glu
              20                  25                  30        
 Ser Lys Thr Lys Leu Arg Phe Val Tyr Arg Pro Phe Gln Val Ala Ile
          35                  40                  45            
 Asn Val Ala Thr His Ser Leu Lys Leu Ile Phe Cys Leu Ile Thr Pro
      50                  55                  60                
 Tyr Thr His Leu Gly Glu Asp Ser Asp Trp Val Pro Leu Asp Asp Glu
  65                  70                  75                  80
 Pro Ile Ile Met Ala Arg Gly Thr Gly Tyr Tyr Asp Trp Pro Val Gly
                  85                  90                  95    
 Ser Leu Met Pro Ile Ala Glu Glu Ala His Leu Glu Ser Tyr Ser Pro
             100                 105                 110        
 Glu Phe Leu Lys Arg Ala Gly His Val Cys Thr Tyr Leu Leu His Glu
         115                 120                 125            
 Gln Ser Glu Asn Ser Asn Pro Asp Ser Glu Thr Ser Ser Val Thr Ile
     130                 135                 140                
 Arg Glu Thr Pro Arg Lys Lys Ser Ile Ser Glu Asp Ser Ala Ser Pro
 145                 150                 155                 160
 Val Glu Gly Pro Leu Arg Ala Met Leu Gly Asp Ala Gln Val Gly Lys
                 165                 170                 175    
 Leu Leu Ala Cys His Tyr Arg Ser Glu Asp Ala Arg Lys Gln Glu Arg
             180                 185                 190        
 His Leu Arg Cys Leu Phe Ala Thr Pro Lys Gly Asp Thr Ser Gly Glu
         195                 200                 205            
 Arg Gly Leu Gly Cys Asn Glu Leu Gly Arg Ser Leu Arg Gln Ala Ser
     210                 215                 220                
 Ala Leu Ile Arg Lys Gln Arg Val Pro Phe Gly Asp Arg Pro Arg Lys
 225                 230                 235                 240
 Trp Gly Arg Pro Trp Lys Ser Leu Lys Arg Gln Arg Thr Phe Val Glu
                 245                 250                 255    
 Lys Lys Pro Phe Asn Cys Thr Glu Cys Gly Lys Ala Phe Ile Tyr His
             260                 265                 270        
 Ser Asp Tyr Ile Leu His Gln Arg Ile His Thr Arg Glu Lys Pro His
         275                 280                 285            
 Arg Ile His Thr Gly Glu Lys Pro Tyr Lys Gly Lys Asp Cys Gly Lys
     290                 295                 300                
 Ala Phe Thr Gln Ser Ser Ser Leu Ile Lys His Gln Arg Cys His Thr
 305                 310                 315                 320
 Gly Glu Lys Pro Tyr Lys Cys Gly Gln Cys Gly Lys Phe Tyr Ser Gln
                 325                 330                 335    
 Val Ser His Leu Thr Arg His Gln Lys Ile His Thr Gly Glu Lys Pro
             340                 345                 350        
 Tyr Gln Cys Gly Glu Cys Gly Lys Ala Phe Cys His Thr Ser Ser Leu
         355                 360                 365            
 Thr Gln His Gln Thr Thr His Thr Gly Glu Lys Pro Tyr Lys Cys Asn
     370                 375                 380                
 Lys Cys Gly Lys Thr Phe Ser His Ser Ser Ser Leu Thr Glu His Gln
 385                 390                 395                 400
 Arg Val His Thr Gly Glu Lys Pro Tyr Glu Cys Thr Asp Cys Gly Lys
                 405                 410                 415    
 Ala Phe Ser His Ser Ser Ser Leu Thr Gln His Gln Arg Ile His Thr
             420                 425                 430        
 Gly Glu Lys Pro Tyr Ala Cys His Glu Cys Gly Lys Ala Tyr Thr Gln
         435                 440                 445            
 Ile Ser His Leu Met Arg His Gln Ser Thr His Val Gly Glu Lys Pro
     450                 455                 460                
 Tyr Val Cys Asn Glu Cys Gly Lys Ala Phe Ser His Thr Ser Ser Phe
 465                 470                 475                 480
 Thr Gln His Gln Thr Ile His Thr Gly Glu Lys Pro Tyr Lys Cys Thr
                 485                 490                 495    
 Glu Cys Gly Lys Thr Phe Ser Gln Asn Ser Ser Leu Thr His His Gln
             500                 505                 510        
 Arg Ile His Thr Gly Glu Lys Pro Tyr Glu Cys Lys Val Cys Gly Lys
         515                 520                 525            
 Ala Tyr Thr Gln Ile Ser His Leu Ile Gln His Gln Arg Ile His Thr
     530                 535                 540                
 Gly Glu Arg Pro Tyr Glu Gly Arg Glu Cys Gly Lys Ala Phe Ser Gln
 545                 550                 555                 560
 Ser Thr His Leu Ile Glu His Gln Lys Ile His Thr Gly Glu Lys Pro
                 565                 570                 575    
 Tyr Lys Cys Lys Glu Cys Gly Lys Thr Phe Ser His Asn Ser Ser Leu
             580                 585                 590        
 Thr Gln His Gln Lys Ile His Thr Gly Glu Lys Pro Tyr Ala Cys Lys
         595                 600                 605            
 Glu Cys Gly Lys Ala Phe Asn Gln Ser Ile His Leu Ile Gln His Gln
     610                 615                 620                
 Arg Ile His Thr Gly Glu Lys Pro Tyr Lys Cys Ser Asp Cys Gly Arg
 625                 630                 635                 640
 Thr Tyr Thr Gln Ile Ser His Leu Leu Gln His Gln Lys Val His Thr
                 645                 650                 655    
 Gly Ser Lys Arg Tyr Thr Cys Glu Glu Cys Gly Glu Gly Phe Ser Trp
             660                 665                 670        
 Ser Ser His Leu Thr Glu His Gln Arg Leu His Thr Gly Gln Asn Ala
         675                 680                 685            
 Tyr Ile Cys Asp Asp Phe Glu Lys Ala Phe Ala Trp Gly Thr Gln Leu
     690                 695                 700                
 Ala Asp His Gln Arg Thr His Ala Asp
 705                 710            



      <210> 1004
      <211> 132
      <212> PRT
      <213> Homo sapiens


      <400> 1004
 Met Asp Leu Ala Gln Met His Ala Cys Gln Gly Pro Gly Asn Asp Leu
   1               5                  10                  15    
 Tyr Ile Glu Ala Ser Ala Ala Leu Cys Ala Gly Ser Asp Phe Ser Val
              20                  25                  30        
 Ser Gly Gly Leu Gln Trp Val Gln Leu Val Ala His Gly Ser Ala Gly
          35                  40                  45            
 Asp Asp Asn Gly Trp Leu Arg Cys His Arg Pro Pro Trp Gln Gly Leu
      50                  55                  60                
 Gly Asp Asn Glu Leu Asp Gly Cys Ser Gly Glu Val Asn Val Ser Gln
  65                  70                  75                  80
 Asp Phe Val Lys Thr Leu Leu Arg Ile Cys Asn Ala Ile Pro Ser Phe
                  85                  90                  95    
 Arg Gly Leu Leu Glu Ser Cys Met Phe Gly Cys Arg Ala Arg Val Thr
             100                 105                 110        
 Arg Asn Phe Trp Thr Leu Val Pro Ser Thr Ser Ala Gly Cys Gly Cys
         115                 120                 125            
 Gln Ser Gln Gln
     130        



      <210> 1005
      <211> 137
      <212> PRT
      <213> Homo sapiens


      <400> 1005
 Met Ala Val Leu Val Thr Gly Pro His Pro Trp Pro Leu Thr Arg Gly
   1               5                  10                  15    
 Met Cys Val Ala Glu Gly Leu Leu Thr Met Leu Glu Leu Arg Arg Leu
              20                  25                  30        
 Leu Ser Leu Arg Glu Pro Pro Leu Ser Pro Lys Ile Cys Ser Val Pro
          35                  40                  45            
 Leu Ile Leu Leu Pro Gly Pro Trp Arg Leu Gly Gln Ala Ala Pro His
      50                  55                  60                
 Thr Ser Thr Pro His Pro Leu Leu Pro Gly Ser Ser Cys Gly Leu Pro
  65                  70                  75                  80
 Ser Thr Val Arg Arg Leu Trp Asp Arg Thr Glu Ser Leu Ala Ala Cys
                  85                  90                  95    
 Gly Ala Pro Val Pro Ala Ala Ala Pro Arg Leu Arg Ser Gly Tyr Pro
             100                 105                 110        
 His Pro Arg His Arg Arg Pro Pro Ala Pro Pro Thr Ala Ala His Ala
         115                 120                 125            
 Arg Arg Val His Ala Ala Pro Ala Pro
     130                 135        



      <210> 1006
      <211> 82
      <212> PRT
      <213> Homo sapiens


      <400> 1006
 Met Pro Arg Gly Ser Ser Val Arg Cys His Leu His Gly His His Leu
   1               5                  10                  15    
 Gln Ser Thr Gly Phe Met Val Leu Leu His Leu Gly Gly Ser Arg Glu
              20                  25                  30        
 Arg Asp Leu Gly Ser Gly Cys Gly Gln Gly Ser Phe Thr Cys Leu Leu
          35                  40                  45            
 Gly Ala Pro Pro Gln Arg Asp Ala Gly Arg Gln Ser Leu Ser Ala Ile
      50                  55                  60                
 Ser Pro Glu Trp Arg Val Cys Ala Val Gly Pro Ser His Arg Phe Pro
  65                  70                  75                  80
 Val Arg
        



      <210> 1007
      <211> 578
      <212> PRT
      <213> Homo sapiens


      <400> 1007
 Met Ala Ala Pro Arg Pro Ser Pro Ala Ile Ser Val Ser Val Ser Ala
   1               5                  10                  15    
 Pro Ala Phe Tyr Cys Pro Ala Glu Glu Val Arg Pro Cys Gly Gly Pro
              20                  25                  30        
 Lys Ala Gln Ser Glu Ser Leu Pro Gly Pro Gly Asp Ser Glu Pro Pro
          35                  40                  45            
 Pro Ala Pro Gly Gly Pro Ala Arg Thr Asp Gly Pro Gly Gly Arg Asp
      50                  55                  60                
 Ser Pro Arg Pro Pro Arg Gly Arg Leu Ser Ala Val Ser Ser Thr Ser
  65                  70                  75                  80
 Pro Leu Leu Gly Asp Gly Asp Asp Ala Glu Arg Cys Leu Trp Glu Val
                  85                  90                  95    
 Pro Phe Pro Pro Pro Pro Pro Pro Ile Glu Glu Ser Phe Pro Pro Ala
             100                 105                 110        
 Pro Leu Glu Glu Glu Ile Phe Pro Ser Pro Pro Pro Pro Pro Glu Glu
         115                 120                 125            
 Glu Gly Gly Pro Glu Ala Pro Ile Pro Pro Pro Pro Gln Pro Arg Glu
     130                 135                 140                
 Lys Val Ser Ser Ile Asp Leu Glu Ile Asp Ser Leu Ser Ser Leu Leu
 145                 150                 155                 160
 Asp Asp Met Thr Lys Asn Asp Pro Phe Lys Ala Arg Val Ser Ser Gly
                 165                 170                 175    
 Tyr Val Pro Pro Pro Val Ala Thr Pro Phe Ser Ser Lys Ser Ser Thr
             180                 185                 190        
 Lys Pro Ala Ala Gly Gly Thr Ala Pro Leu Pro Pro Trp Lys Ser Pro
         195                 200                 205            
 Ser Ser Ser Gln Pro Leu Pro Gln Val Pro Ala Pro Ala Gln Ser Gln
     210                 215                 220                
 Thr Gln Phe His Val Gln Pro Gln Pro Gln Pro Lys Pro Gln Val Gln
 225                 230                 235                 240
 Leu His Val Gln Ser Gln Thr Gln Pro Val Ser Leu Ala Asn Thr Gln
                 245                 250                 255    
 Pro Arg Gly Pro Pro Ala Ser Ser Pro Ala Pro Ala Pro Lys Phe Ser
             260                 265                 270        
 Pro Val Thr Pro Lys Phe Thr Pro Val Ala Ser Lys Phe Ser Pro Gly
         275                 280                 285            
 Ala Pro Gly Gly Ser Gly Ser Gln Pro Asn Gln Lys Leu Gly His Pro
     290                 295                 300                
 Glu Ala Leu Ser Ala Gly Thr Gly Ser Pro Gln Pro Pro Ser Phe Thr
 305                 310                 315                 320
 Tyr Ala Gln Gln Arg Glu Lys Pro Arg Val Gln Glu Lys Gln His Pro
                 325                 330                 335    
 Val Pro Pro Pro Ala Gln Asn Gln Asn Gln Val Arg Ser Pro Trp Arg
             340                 345                 350        
 Pro Gln Gly Pro Leu Thr Leu Lys Glu Val Glu Glu Leu Glu Gln Leu
         355                 360                 365            
 Thr Gln Gln Leu Met Gln Asp Met Glu His Pro Gln Arg Gln Asn Val
     370                 375                 380                
 Ala Val Asn Glu Leu Cys Gly Arg Cys His Gln Pro Leu Ala Arg Ala
 385                 390                 395                 400
 Gln Pro Ala Val Arg Ala Leu Gly Gln Leu Phe His Ile Ala Cys Phe
                 405                 410                 415    
 Thr Cys His Gln Cys Ala Gln Gln Leu Gln Gly Gln Gln Phe Tyr Ser
             420                 425                 430        
 Leu Glu Gly Ala Pro Tyr Cys Glu Gly Cys Tyr Thr Asp Thr Leu Glu
         435                 440                 445            
 Lys Cys Asn Thr Cys Gly Glu Pro Ile Thr Asp Arg Met Leu Arg Ala
     450                 455                 460                
 Thr Gly Lys Ala Tyr His Pro His Cys Phe Thr Cys Val Val Cys Ala
 465                 470                 475                 480
 Arg Pro Leu Glu Gly Thr Ser Phe Ile Val Asp Gln Ala Asn Arg Pro
                 485                 490                 495    
 His Cys Val Pro Asp Tyr His Lys Gln Tyr Ala Pro Arg Cys Ser Val
             500                 505                 510        
 Cys Ser Glu Pro Ile Met Pro Glu Pro Gly Arg Asp Glu Thr Val Arg
         515                 520                 525            
 Val Val Ala Leu Asp Lys Asn Phe His Met Lys Cys Tyr Lys Cys Glu
     530                 535                 540                
 Asp Cys Gly Lys Pro Leu Ser Ile Glu Ala Asp Asp Asn Gly Cys Phe
 545                 550                 555                 560
 Pro Leu Asp Gly His Val Leu Cys Arg Lys Cys His Thr Ala Arg Ala
                 565                 570                 575    
 Gln Thr
        



      <210> 1008
      <211> 168
      <212> PRT
      <213> Homo sapiens


      <400> 1008
 Met Ile Lys Cys Met Ser Ser Arg Phe Glu Asp Asn Gly Ile Arg Ser
   1               5                  10                  15    
 Val Ile Gln Leu Leu Val Pro Leu Thr Phe Ser Asp Pro Gly Glu Gly
              20                  25                  30        
 Ser Thr Gly Phe Ala Phe Ile Arg Pro Lys Met Pro Phe Phe Gly Asn
          35                  40                  45            
 Thr Phe Ser Pro Lys Lys Thr Pro Pro Arg Lys Ser Ala Ser Leu Ser
      50                  55                  60                
 Asn Leu His Ser Leu Asp Arg Ser Thr Arg Glu Val Glu Leu Gly Leu
  65                  70                  75                  80
 Glu Tyr Gly Ser Pro Thr Met Asn Leu Ala Gly Gln Ser Leu Lys Phe
                  85                  90                  95    
 Glu Asn Gly Gln Trp Ile Ala Glu Thr Gly Val Ser Gly Gly Val Asp
             100                 105                 110        
 Arg Arg Glu Val Gln Arg Leu Arg Arg Arg Asn Gln Gln Leu Glu Glu
         115                 120                 125            
 Glu Asn Asn Leu Leu Arg Leu Lys Val Asp Ile Leu Leu Asp Met Leu
     130                 135                 140                
 Ser Glu Ser Thr Ala Glu Ser His Leu Met Glu Lys Glu Leu Asp Glu
 145                 150                 155                 160
 Leu Arg Ile Ser Arg Lys Arg Lys
                 165            



      <210> 1009
      <211> 129
      <212> PRT
      <213> Homo sapiens


      <400> 1009
 Met Ser Ser Gly Cys Leu Leu Ser Val Leu His Pro Pro Trp Pro Gly
   1               5                  10                  15    
 Leu Pro Phe His Leu His Leu Ser Phe Ala Ser Phe Pro Pro Arg Val
              20                  25                  30        
 Arg Ala Ser Lys Pro Pro Pro Ser Phe Gly Asn Val Gly Ser Lys Glu
          35                  40                  45            
 Gly Thr Leu Arg Gly Gln Thr Pro Ala Pro Gln Asn Trp Ala Pro Ser
      50                  55                  60                
 Pro Gly Gln Glu Ala Arg Arg His Ile Thr Pro Leu Ser Ile His Phe
  65                  70                  75                  80
 His Gln Ala Pro Leu Arg Val Pro Leu Leu Val Leu Gly Leu Gln Asp
                  85                  90                  95    
 Gly His Arg Leu Ala Cys Leu Gln Ala His Phe Met Ala Ala Ser Gly
             100                 105                 110        
 His Lys Arg Val Arg Gly Tyr Asp Leu Val His Gly Gly Asn Arg Gly
         115                 120                 125            
 His
    



      <210> 1010
      <211> 193
      <212> PRT
      <213> Homo sapiens


      <400> 1010
 Met Leu Ser Cys Asn Ile Cys Gly Glu Thr Val Thr Ser Glu Pro Asp
   1               5                  10                  15    
 Met Lys Ala His Leu Ile Val His Met Glu Ser Glu Ile Ile Cys Pro
              20                  25                  30        
 Phe Cys Lys Leu Ser Gly Val Asn Tyr Asp Glu Met Cys Phe His Ile
          35                  40                  45            
 Glu Thr Ala His Phe Glu Gln Asn Thr Leu Glu Arg Asn Phe Glu Arg
      50                  55                  60                
 Ile Asn Thr Val Gln Tyr Gly Thr Ser Asp Asn Lys Lys Asp Asn Thr
  65                  70                  75                  80
 Leu Gln Cys Gly Met Glu Val Asn Ser Ser Ile Leu Ser Gly Cys Ala
                  85                  90                  95    
 Ser Asn His Pro Lys Asn Ser Ala Gln Asn Leu Thr Lys Asp Ser Thr
             100                 105                 110        
 Leu Lys His Glu Gly Phe Tyr Ser Glu Asn Leu Thr Glu Ser Arg Lys
         115                 120                 125            
 Phe Leu Lys Ser Arg Glu Lys Gln Ser Ser Leu Thr Glu Ile Lys Gly
     130                 135                 140                
 Ser Val Tyr Glu Thr Thr Tyr Ser Pro Pro Glu Cys Pro Phe Cys Gly
 145                 150                 155                 160
 Lys Ile Glu Glu His Ser Glu Asp Met Glu Thr His Val Lys Thr Lys
                 165                 170                 175    
 His Ala Asn Leu Leu Asp Ile Pro Leu Glu Gly Lys Val Phe Ile Ser
             180                 185                 190        
 Leu
    



      <210> 1011
      <211> 89
      <212> PRT
      <213> Homo sapiens


      <400> 1011
 Met Ala Ser Val Ser Glu Leu Ala Cys Ile Tyr Ser Ala Leu Ile Leu
   1               5                  10                  15    
 His Asp Asp Glu Val Thr Val Thr Ala Leu Ala Asn Val Asn Ile Gly
              20                  25                  30        
 Ser Leu Ile Cys Asn Val Gly Ala Gly Gly Pro Ala Pro Ala Ala Gly
          35                  40                  45            
 Ala Ala Pro Ala Gly Gly Pro Ala Pro Ser Thr Ala Ala Ala Pro Ala
      50                  55                  60                
 Glu Glu Lys Lys Val Glu Ala Lys Lys Glu Glu Ser Glu Glu Ser Asp
  65                  70                  75                  80
 Asp Asp Met Gly Phe Gly Leu Phe Asp
                  85                



      <210> 1012
      <211> 221
      <212> PRT
      <213> Homo sapiens


      <400> 1012
 Met Ala Ala Ala Ser Gly Ser Val Leu Gln Arg Cys Ile Val Ser Pro
   1               5                  10                  15    
 Ala Gly Arg His Ser Ala Ser Leu Ile Phe Leu His Gly Ser Gly Asp
              20                  25                  30        
 Ser Gly Gln Gly Leu Arg Met Trp Ile Lys Gln Val Leu Asn Gln Asp
          35                  40                  45            
 Leu Thr Phe Gln His Ile Lys Ile Ile Tyr Pro Thr Ala Pro Pro Arg
      50                  55                  60                
 Phe Lys Ile Thr Asn Asp Cys Pro Glu His Leu Glu Ser Ile Asp Val
  65                  70                  75                  80
 Met Cys Gln Val Leu Thr Asp Leu Ile Asp Glu Glu Val Lys Ser Gly
                  85                  90                  95    
 Ile Lys Lys Asn Arg Ile Leu Ile Gly Gly Phe Ser Met Gly Gly Cys
             100                 105                 110        
 Met Ala Met His Leu Ala Tyr Arg Asn His Gln Asp Val Ala Gly Val
         115                 120                 125            
 Phe Ala Leu Ser Ser Phe Leu Asn Lys Ala Ser Ala Val Tyr Gln Ala
     130                 135                 140                
 Leu Gln Lys Ser Asn Gly Val Leu Pro Glu Leu Phe Gln Cys His Gly
 145                 150                 155                 160
 Thr Ala Asp Glu Leu Val Leu His Ser Trp Ala Glu Glu Thr Asn Ser
                 165                 170                 175    
 Met Leu Lys Ser Leu Gly Val Thr Thr Lys Phe His Ser Phe Pro Asn
             180                 185                 190        
 Val Tyr His Glu Leu Ser Lys Thr Glu Leu Asp Ile Leu Lys Leu Trp
         195                 200                 205            
 Ile Leu Thr Lys Leu Pro Gly Glu Met Glu Lys Gln Lys
     210                 215                 220    



      <210> 1013
      <211> 196
      <212> PRT
      <213> Homo sapiens


      <400> 1013
 Met Ser Cys Thr Ser Gln Gly Leu Ser Arg Ala Ser Tyr Phe Arg Ala
   1               5                  10                  15    
 Gly Val Cys Ala Ala Leu Glu Ala Trp Pro Ala Leu Gln Ile Ala Val
              20                  25                  30        
 Glu Asn Gly Phe Gly Gly Val His Ser Gln Glu Lys Ala Lys Trp Leu
          35                  40                  45            
 Gly Gly Ala Val Glu Asp Tyr Phe Met Arg Asn Ala Asp Leu Glu Leu
      50                  55                  60                
 Asp Glu Val Glu Asp Phe Leu Gly Glu Leu Leu Thr Asn Glu Phe Asp
  65                  70                  75                  80
 Thr Val Val Glu Asp Gly Ser Leu Pro Gln Val Ser Gln Gln Leu Gln
                  85                  90                  95    
 Thr Met Phe His His Phe Gln Arg Gly Asp Gly Ala Ala Leu Arg Glu
             100                 105                 110        
 Met Ala Ser Cys Ile Thr Gln Arg Lys Cys Lys Val Thr Ala Thr Ala
         115                 120                 125            
 Leu Lys Thr Ala Arg Glu Thr Asp Glu Asp Glu Asp Asp Val Asp Ser
     130                 135                 140                
 Val Glu Glu Met Glu Val Thr Ala Thr Asn Asp Gly Ala Ala Thr Asp
 145                 150                 155                 160
 Gly Val Cys Pro Gln Pro Glu Pro Ser Asp Pro Asp Ala Gln Thr Ile
                 165                 170                 175    
 Lys Glu Glu Asp Ile Val Glu Asp Gly Trp Thr Ile Ser Gly Glu Lys
             180                 185                 190        
 Asn Glu Trp Gly
         195    



      <210> 1014
      <211> 198
      <212> PRT
      <213> Homo sapiens


      <400> 1014
 Met Ser Thr Val Asp Leu Ala Arg Val Gly Ala Cys Ile Leu Lys His
   1               5                  10                  15    
 Ala Val Thr Gly Glu Ala Val Glu Leu Arg Ser Leu Trp Arg Glu His
              20                  25                  30        
 Ala Cys Val Val Ala Gly Leu Arg Arg Phe Gly Cys Val Val Cys Arg
          35                  40                  45            
 Trp Ile Ala Gln Asp Leu Ser Ser Leu Ala Gly Leu Leu Asp Gln His
      50                  55                  60                
 Gly Val Arg Leu Val Gly Val Gly Pro Glu Ala Leu Gly Leu Gln Glu
  65                  70                  75                  80
 Phe Leu Asp Gly Asp Tyr Phe Ala Gly Glu Leu Tyr Leu Asp Glu Ser
                  85                  90                  95    
 Lys Gln Leu Tyr Lys Glu Leu Gly Phe Lys Arg Tyr Asn Ser Leu Ser
             100                 105                 110        
 Ile Leu Pro Ala Ala Leu Gly Lys Pro Val Arg Asp Val Ala Ala Lys
         115                 120                 125            
 Ala Lys Ala Val Gly Ile Gln Gly Asn Leu Ser Gly Asp Leu Leu Gln
     130                 135                 140                
 Ser Gly Gly Leu Leu Val Val Ser Lys Gly Gly Asp Lys Val Leu Leu
 145                 150                 155                 160
 His Phe Val Gln Lys Ser Pro Gly Asp Tyr Val Pro Lys Glu His Ile
                 165                 170                 175    
 Leu Gln Val Leu Gly Ile Ser Ala Glu Val Cys Ala Ser Asp Pro Pro
             180                 185                 190        
 Gln Cys Asp Arg Glu Val
         195            



      <210> 1015
      <211> 106
      <212> PRT
      <213> Homo sapiens


      <400> 1015
 Met Ser Gln Ile Phe Leu Cys Tyr Leu Asp Ile Cys Gly Lys Ala Glu
   1               5                  10                  15    
 Ser Phe Leu Thr Val Lys Ala Glu Val Ser Thr Gly Gly Asn Leu Leu
              20                  25                  30        
 Val Val Ser Pro Thr Thr Leu Pro Arg Val Leu Ser Thr Lys Glu Val
          35                  40                  45            
 Lys Arg Thr Glu Lys Glu Ile Ser Ile Ser Ala Ala Arg Ala Gly Ile
      50                  55                  60                
 Cys Leu Pro Asp Ser Leu Cys Phe Leu Phe His Arg His Pro Phe Arg
  65                  70                  75                  80
 Arg Glu Leu His Gln Phe Ile Met Arg Val Arg Glu Ala Lys Ala Leu
                  85                  90                  95    
 Arg Cys Val Gln Gly Ile Glu Ser Trp Cys
             100                 105    



      <210> 1016
      <211> 253
      <212> PRT
      <213> Homo sapiens


      <400> 1016
 Met His Pro Phe Tyr Thr Arg Ala Ala Thr Met Ile Gly Glu Ile Ala
   1               5                  10                  15    
 Ala Ala Val Ser Phe Ile Ser Lys Phe Leu Arg Thr Lys Gly Leu Thr
              20                  25                  30        
 Ser Glu Arg Gln Leu Gln Thr Phe Ser Gln Ser Leu Gln Glu Leu Leu
          35                  40                  45            
 Ala Gly Glu Gln Gly Glu Gly Val Gly Gly Thr Arg Ala Pro His Pro
      50                  55                  60                
 Trp Val Arg Val Arg Pro Ser Gly Leu Arg Glu Pro Arg Gln Arg Pro
  65                  70                  75                  80
 Gly Ala Gly Arg Ala Trp Ala Pro Pro Arg Asp Arg Trp Gln Asn Gly
                  85                  90                  95    
 Glu Glu Lys Thr Thr Arg Thr Thr Lys Lys Leu Lys Pro Thr Glu Ala
             100                 105                 110        
 Gly Ala Ala Val Arg Gly Pro Ser Ala Asp Leu Gly Thr Lys Glu Pro
         115                 120                 125            
 Trp Gly Trp Glu His Tyr Lys His His Trp Phe Pro Glu Lys Pro Cys
     130                 135                 140                
 Lys Gly Ser Gly Tyr Arg Cys Ile Arg Ile Asn His Lys Met Asp Pro
 145                 150                 155                 160
 Leu Ile Gly Gln Ala Ala Gln Arg Ile Gly Leu Ser Ser Gln Glu Leu
                 165                 170                 175    
 Phe Arg Leu Leu Pro Ser Glu Leu Thr Leu Trp Val Asp Pro Tyr Glu
             180                 185                 190        
 Val Ser Tyr Arg Ile Gly Glu Asp Gly Ser Ile Cys Val Leu Tyr Glu
         195                 200                 205            
 Ala Ser Pro Ala Gly Gly Ser Thr Gln Asn Ser Thr Asn Val Gln Met
     210                 215                 220                
 Val Asp Ser Arg Ile Ser Cys Lys Glu Glu Leu Leu Leu Gly Arg Thr
 225                 230                 235                 240
 Ser Pro Ser Lys Asn Tyr Asn Met Met Thr Val Ser Gly
                 245                 250            



      <210> 1017
      <211> 566
      <212> PRT
      <213> Homo sapiens


      <400> 1017
 Met Leu Ala Ile Gly Leu Ser Leu Cys Asp His Leu Ser Gln Asp Val
   1               5                  10                  15    
 Phe Cys Leu His Glu Ser Lys Phe Glu Glu Glu Arg Met Val Ala Gly
              20                  25                  30        
 Trp Leu Thr Asn Tyr Ser Gln Asp Ser Val Thr Phe Glu Asp Val Ala
          35                  40                  45            
 Val Asp Phe Thr Gln Glu Glu Trp Thr Leu Leu Asp Gln Thr Gln Arg
      50                  55                  60                
 Asn Leu Tyr Arg Asp Val Met Leu Glu Asn Tyr Lys Asn Leu Val Ala
  65                  70                  75                  80
 Val Asp Trp Glu Ser His Ile Asn Thr Lys Trp Ser Ala Pro Gln Gln
                  85                  90                  95    
 Asn Phe Leu Gln Gly Lys Thr Ser Ser Val Val Glu Met Glu Arg Asn
             100                 105                 110        
 His Phe Gly Glu Glu Leu Phe Asp Phe Asn Gln Cys Glu Lys Ala Leu
         115                 120                 125            
 Ser Glu His Ser Cys Leu Lys Thr His Arg Arg Thr Tyr Phe Arg Lys
     130                 135                 140                
 Lys Thr Cys Glu Cys Asn Gln Cys Glu Lys Ala Phe Arg Lys Pro Ser
 145                 150                 155                 160
 Ile Phe Thr Leu His Lys Lys Thr Asp Ile Gly Glu Glu Leu Pro Asn
                 165                 170                 175    
 Cys Asn Gln Cys Glu Thr Ala Phe Ser Gln His Leu His Leu Val Cys
             180                 185                 190        
 Lys Lys Thr Ser Gln Asn Leu His Leu Val Cys Lys Lys Thr His Thr
         195                 200                 205            
 Gln Glu Lys Pro Tyr Lys Cys Ser Asp Cys Glu Lys Gly Leu Pro Ser
     210                 215                 220                
 Ser Ser His Leu Arg Glu Cys Val Arg Ile Tyr Gly Gly Glu Arg Pro
 225                 230                 235                 240
 Tyr Thr His Lys Glu Tyr Val Glu Thr Phe Ser His Ser Thr Ala Leu
                 245                 250                 255    
 Phe Val His Met Gln Thr Gln Asp Gly Glu Lys Phe Tyr Glu Cys Lys
             260                 265                 270        
 Ala Cys Gly Lys Pro Phe Thr Glu Ser Ser Tyr Leu Thr Gln His Leu
         275                 280                 285            
 Arg Thr His Ser Arg Val Leu Pro Ile Glu His Lys Lys Phe Gly Lys
     290                 295                 300                
 Ala Phe Ala Phe Ser Pro Asp Leu Ala Lys His Ile Arg Leu Arg Thr
 305                 310                 315                 320
 Arg Gly Lys His Tyr Val Cys Asn Glu Cys Gly Lys Glu Phe Thr Cys
                 325                 330                 335    
 Phe Ser Lys Leu Asn Ile His Ile Arg Val His Thr Gly Glu Lys Pro
             340                 345                 350        
 Tyr Glu Cys Asn Lys Cys Gly Lys Ala Phe Thr Asp Ser Ser Gly Leu
         355                 360                 365            
 Ile Lys His Arg Arg Thr His Thr Gly Glu Lys Pro Tyr Glu Cys Lys
     370                 375                 380                
 Glu Cys Gly Lys Ala Phe Ala Asn Ser Ser His Leu Thr Val His Met
 385                 390                 395                 400
 Arg Thr His Thr Gly Glu Lys Pro Tyr Gln Cys Lys Glu Cys Gly Lys
                 405                 410                 415    
 Ala Phe Ile Asn Ser Ser Ser Phe Lys Ser His Met Gln Thr His Pro
             420                 425                 430        
 Gly Val Lys Pro Tyr Asp Cys Gln Gln Cys Gly Lys Ala Phe Ile Arg
         435                 440                 445            
 Ser Ser Phe Leu Ile Arg His Leu Arg Ser His Ser Ala Glu Arg Pro
     450                 455                 460                
 Phe Glu Cys Glu Glu Cys Gly Lys Ala Phe Arg Tyr Ser Ser His Leu
 465                 470                 475                 480
 Ser Gln His Lys Arg Ile His Thr Gly Glu Arg Pro Tyr Lys Cys Gln
                 485                 490                 495    
 Lys Cys Gly Gln Ala Phe Ser Ile Ser Ser Gly Leu Thr Val His Met
             500                 505                 510        
 Arg Thr His Thr Gly Glu Arg Pro Phe Glu Cys Gln Glu Cys Gly Lys
         515                 520                 525            
 Ala Phe Thr Arg Ser Thr Tyr Leu Ile Arg His Leu Arg Ser His Ser
     530                 535                 540                
 Val Glu Lys Pro Tyr Lys Glu Cys Gly Gln Thr Phe Ser Asn Ser Ser
 545                 550                 555                 560
 Cys Leu Thr Glu Cys Val
                 565    



      <210> 1018
      <211> 71
      <212> PRT
      <213> Homo sapiens


      <400> 1018
 Met His Thr Phe Leu Ser Leu Thr His Ser Cys Ser Ser Ile Arg Ala
   1               5                  10                  15    
 Leu Glu Ser Pro Leu Pro Ala Gly Ser Cys Cys Thr Pro Ser Ala Trp
              20                  25                  30        
 His Thr Cys Gly Pro Glu Glu Val Leu Lys His Val Ile Pro Gly Gly
          35                  40                  45            
 Leu Arg Ser Gly Trp Leu Leu Cys Val Thr His Gly Gly Lys Gln Ser
      50                  55                  60                
 Ser Val Gly His Val Pro Pro
  65                  70    



      <210> 1019
      <211> 83
      <212> PRT
      <213> Homo sapiens


      <400> 1019
 Met Val Leu Cys Val Gly Glu Cys Val Pro Asn Leu Leu Ser Leu Ser
   1               5                  10                  15    
 Cys Phe Ser Val Thr Val Leu Leu Glu Val Lys Phe Ile Gln Gly Asn
              20                  25                  30        
 Leu Leu Thr Asn Tyr Ser Phe Leu Trp Pro Gly Val Lys Gly Ser Met
          35                  40                  45            
 Ala His Thr Gly Glu Asn Lys Glu Gly Leu Val Leu Ser Cys Ile Asn
      50                  55                  60                
 Asn Thr Gly Cys Ile Pro Pro Ala Arg Asp Phe Tyr Leu Arg Arg Pro
  65                  70                  75                  80
 Met Lys His
            



      <210> 1020
      <211> 317
      <212> PRT
      <213> Homo sapiens


      <400> 1020
 Met Gly Pro Ser Asn Gln Ala Val Arg Leu His Ser Ser Cys Pro Cys
   1               5                  10                  15    
 Ser Ser Gly Trp Arg Thr Glu Asp Arg Thr Leu Lys Pro Gln Val Ala
              20                  25                  30        
 Glu Lys Pro Gly Val Lys Met Thr Glu Arg Phe Asp Cys His His Cys
          35                  40                  45            
 Asn Glu Ser Leu Phe Gly Lys Lys Tyr Ile Leu Arg Glu Glu Ser Pro
      50                  55                  60                
 Tyr Cys Val Val Cys Phe Glu Thr Leu Phe Ala Asn Thr Cys Glu Glu
  65                  70                  75                  80
 Cys Gly Lys Pro Ile Gly Cys Asp Cys Lys Asp Leu Ser Tyr Lys Asp
                  85                  90                  95    
 Arg His Trp His Glu Ala Cys Phe His Cys Ser Gln Cys Arg Asn Ser
             100                 105                 110        
 Leu Val Asp Lys Pro Phe Ala Ala Lys Glu Asp Gln Leu Leu Cys Thr
         115                 120                 125            
 Asp Cys Tyr Ser Asn Glu Tyr Ser Ser Lys Cys Gln Glu Cys Lys Lys
     130                 135                 140                
 Thr Ile Met Pro Gly Thr Arg Lys Met Glu Tyr Lys Gly Ser Ser Trp
 145                 150                 155                 160
 His Glu Thr Cys Phe Ile Cys His Arg Cys Gln Gln Pro Ile Gly Thr
                 165                 170                 175    
 Lys Ser Phe Ile Pro Lys Asp Asn Gln Asn Phe Cys Val Pro Cys Tyr
             180                 185                 190        
 Glu Lys Gln His Ala Met Gln Cys Val Gln Cys Lys Met Pro Ile Thr
         195                 200                 205            
 Thr Gly Gly Val Thr Tyr Arg Glu Gln Pro Trp His Lys Glu Cys Phe
     210                 215                 220                
 Val Cys Thr Ala Cys Arg Lys Gln Leu Ser Gly Gln Arg Phe Thr Ala
 225                 230                 235                 240
 Arg Asp Asp Phe Ala Tyr Cys Leu Asn Cys Phe Cys Asp Leu Tyr Ala
                 245                 250                 255    
 Lys Lys Cys Ala Gly Cys Thr Asn Pro Ile Ser Gly Leu Gly Gly Thr
             260                 265                 270        
 Lys Tyr Ile Ser Phe Glu Glu Arg Gln Trp His Asn Asp Cys Phe Asn
         275                 280                 285            
 Cys Lys Lys Cys Ser Leu Ser Leu Val Gly Arg Gly Phe Leu Thr Glu
     290                 295                 300                
 Arg Asp Asp Ile Leu Cys Pro Asp Cys Gly Lys Asp Ile
 305                 310                 315        



      <210> 1021
      <211> 166
      <212> PRT
      <213> Homo sapiens


      <400> 1021
 Met Phe Leu Val Leu Lys Lys Lys His Ile Cys His Arg Asn Leu Val
   1               5                  10                  15    
 Asn Ile Leu Gln Leu Asn Met Tyr Val Cys Cys Leu Asp Lys Cys Asn
              20                  25                  30        
 His Cys Lys His Leu Tyr Asp Leu Gly Phe Cys Phe Tyr Phe Glu Met
          35                  40                  45            
 Gly Ala Phe Leu Phe Thr Ser Ser Leu Lys Thr Lys Asn Cys Phe Cys
      50                  55                  60                
 Lys Glu Met Arg Phe Phe Leu Asn Asn Lys Lys Cys Leu Ala Asp Ser
  65                  70                  75                  80
 Leu Leu Asn Lys Asn Leu Pro Asn Phe Leu Ile Asp Tyr Phe Lys Pro
                  85                  90                  95    
 Phe Val Thr Trp Tyr Ser Phe Ala Ser Gln Phe Arg Phe Arg Val Ile
             100                 105                 110        
 Thr Phe Pro Leu Phe Leu Arg Lys Met Lys Lys Val Ile Leu Leu Ser
         115                 120                 125            
 Glu Gly Glu Arg His Ser Phe Ile Phe Phe Phe Phe Phe Phe Phe Phe
     130                 135                 140                
 Tyr Asp Leu Gln Ala Gln Tyr Leu Val Leu Gln Leu Pro Glu Leu Gly
 145                 150                 155                 160
 Ile Val Ala Ala Ala Arg
                 165    



      <210> 1022
      <211> 177
      <212> PRT
      <213> Homo sapiens


      <400> 1022
 Met Ser Val Asn Met Asp Glu Leu Lys His Gln Val Met Ile Asn Gln
   1               5                  10                  15    
 Phe Val Leu Thr Ala Gly Cys Ala Ala Asp Gln Ala Lys Gln Leu Leu
              20                  25                  30        
 Gln Ala Ala His Trp Gln Phe Glu Thr Ala Leu Ser Ala Phe Phe Gln
          35                  40                  45            
 Glu Thr Asn Ile Pro Tyr Ser His His His His Gln Met Met Cys Thr
      50                  55                  60                
 Pro Ala Asn Thr Pro Ala Thr Pro Pro Asn Phe Pro Asp Ala Leu Thr
  65                  70                  75                  80
 Met Phe Ser Arg Leu Lys Ala Ser Glu Ser Phe His Ser Gly Gly Ser
                  85                  90                  95    
 Gly Ser Pro Met Ala Ala Thr Ala Thr Ser Pro Pro Pro His Phe Pro
             100                 105                 110        
 His Ala Ala Thr Ser Ser Ser Ala Ala Ser Ser Trp Pro Thr Ala Ala
         115                 120                 125            
 Ser Pro Pro Gly Gly Pro Gln His His Gln Pro Gln Pro Pro Leu Trp
     130                 135                 140                
 Thr Pro Thr Pro Pro Ser Pro Ala Ser Asp Trp Pro Pro Leu Ala Pro
 145                 150                 155                 160
 Gln Gln Ala Thr Ser Glu Pro Arg Ala His Pro Ala Met Glu Ala Glu
                 165                 170                 175    
 Arg
    



      <210> 1023
      <211> 125
      <212> PRT
      <213> Homo sapiens


      <400> 1023
 Met Ala Ala Gln Ile Val Ser Gly Arg Gly Cys Ser Leu Cys Gly Gly
   1               5                  10                  15    
 Trp Arg Leu Met Ser Ala Val Asp Ser Arg Trp Ala Leu Gly His Val
              20                  25                  30        
 Ser Leu Leu Ala Tyr Cys Leu Arg Gly Thr Glu Val Lys Gly Arg Ser
          35                  40                  45            
 Leu Phe Gly Ser Phe Leu His Ser Gly Cys Ala Pro Val Pro Ala Ser
      50                  55                  60                
 Leu Asn Val Phe Ile Ser Trp Thr Arg Arg Ile Val Gly Arg Asp Leu
  65                  70                  75                  80
 Pro Asp Phe Val His Leu Leu Pro Pro Arg Ile Ser Ser Leu Leu Lys
                  85                  90                  95    
 Lys Leu Ser His Leu Ser Tyr Arg Val Ser His Asn Leu Asp Phe Gly
             100                 105                 110        
 Asp Tyr Met Val Leu Phe Leu Asn Val Ser Leu Ser Leu
         115                 120                 125



      <210> 1024
      <211> 438
      <212> PRT
      <213> Homo sapiens


      <400> 1024
 Met Leu Phe Glu Leu Ser Ala Thr Cys Glu Ala Lys Gly Val Leu Thr
   1               5                  10                  15    
 Phe Arg Asp Val Ala Val Glu Phe Ser Pro Glu Glu Trp Glu Cys Leu
              20                  25                  30        
 Asp Ser Ala Gln Gln Arg Leu Tyr Arg Asp Val Met Leu Glu Asn Tyr
          35                  40                  45            
 Gly Asn Leu Val Ser Leu Gly Leu Ala Ile Phe Lys Pro Asp Leu Met
      50                  55                  60                
 Thr Cys Leu Glu Gln Arg Lys Glu Pro Trp Lys Val Lys Arg Gln Glu
  65                  70                  75                  80
 Ala Val Ala Lys His Pro Ala Gly Ser Phe His Phe Thr Ala Glu Ile
                  85                  90                  95    
 Leu Pro Asp His Asp Ile Lys Asp Ser Phe Gln Lys Val Ile Leu Arg
             100                 105                 110        
 Lys Tyr Gly Ser Cys Asp Leu Asn Asn Leu His Leu Lys Lys Asp Tyr
         115                 120                 125            
 Gln Ser Val Gly Asn Cys Lys Gly Gln Lys Ser Ser Tyr Asn Gly Leu
     130                 135                 140                
 His Gln Cys Leu Ser Ala Thr His Ser Lys Thr Cys Gln Cys Asn Lys
 145                 150                 155                 160
 Cys Gly Arg Gly Phe Gln Leu Cys Ser Ile Phe Thr Glu His Lys Asp
                 165                 170                 175    
 Ile Phe Ser Arg Glu Lys Cys His Lys Cys Glu Glu Cys Gly Lys Asp
             180                 185                 190        
 Cys Arg Leu Phe Ser Asp Phe Thr Arg His Lys Lys Ile His Thr Val
         195                 200                 205            
 Glu Arg Cys Tyr Lys Cys Glu Glu Cys Gly Lys Ala Phe Lys Lys Phe
     210                 215                 220                
 Ser Asn Leu Thr Glu His Lys Arg Val His Thr Gly Glu Lys Pro Tyr
 225                 230                 235                 240
 Lys Cys Glu Gly Cys Gly Lys Thr Phe Thr Cys Ser Ser Thr Leu Val
                 245                 250                 255    
 Lys His Lys Arg Asn His Thr Gly Asp Arg Pro Tyr Lys Cys Glu Glu
             260                 265                 270        
 Cys Gly Lys Ala Phe Lys Cys Phe Ser Asp Leu Thr Asn His Lys Arg
         275                 280                 285            
 Ile His Thr Gly Glu Lys Pro Tyr Lys Cys Glu Glu Cys Asn Lys Ala
     290                 295                 300                
 Tyr Arg Trp Phe Ser Asp Leu Ala Lys His Lys Ile Ile His Thr Gly
 305                 310                 315                 320
 Asp Lys Pro Tyr Thr Cys Asn Glu Cys Gly Lys Ala Phe Lys Trp Phe
                 325                 330                 335    
 Ser Ala Leu Ser Lys His Lys Arg Ile His Thr Gly Glu Lys Pro Tyr
             340                 345                 350        
 Ile Cys Glu Glu Cys Gly Lys Ala Phe Thr Arg Ser Ser Thr Leu Phe
         355                 360                 365            
 Asn His Lys Arg Ile His Met Glu Glu Arg Pro Tyr Lys Cys Glu Glu
     370                 375                 380                
 Cys Ser Lys Thr Phe Lys Cys Phe Ser Asp Leu Thr Asn His Lys Arg
 385                 390                 395                 400
 Ile His Thr Gly Glu Lys Pro Tyr Lys Cys Glu Glu Cys Gly Lys Ala
                 405                 410                 415    
 Ser Ser Trp Phe Ser His Leu Ile Arg His Lys Arg Ile His Thr Arg
             420                 425                 430        
 Glu Lys Leu His Lys Cys
         435            



      <210> 1025
      <211> 527
      <212> PRT
      <213> Homo sapiens


      <400> 1025
 Met Ser Leu Gln Met Val Thr Val Ser Asn Asn Ile Ala Leu Ile Gln
   1               5                  10                  15    
 Pro Gly Phe Ser Leu Met Asn Phe Asp Gly Gln Val Phe Phe Phe Gly
              20                  25                  30        
 Gln Lys Gly Trp Pro Lys Arg Ser Cys Pro Thr Gly Val Phe His Leu
          35                  40                  45            
 Asp Val Lys His Asn His Val Lys Leu Lys Pro Thr Ile Phe Ser Lys
      50                  55                  60                
 Asp Ser Cys Tyr Leu Pro Pro Leu Arg Tyr Pro Ala Thr Cys Thr Phe
  65                  70                  75                  80
 Lys Gly Ser Leu Glu Ser Glu Lys His Gln Tyr Ile Ile His Gly Gly
                  85                  90                  95    
 Lys Thr Pro Asn Asn Glu Val Ser Asp Lys Ile Tyr Val Met Ser Ile
             100                 105                 110        
 Val Cys Lys Asn Asn Lys Lys Val Thr Phe Arg Cys Thr Glu Lys Asp
         115                 120                 125            
 Leu Val Gly Asp Val Pro Glu Ala Arg Tyr Gly His Ser Ile Asn Val
     130                 135                 140                
 Val Tyr Ser Arg Gly Lys Ser Met Gly Val Leu Phe Gly Gly Arg Ser
 145                 150                 155                 160
 Tyr Met Pro Ser Thr His Arg Thr Thr Glu Lys Trp Asn Ser Val Ala
                 165                 170                 175    
 Asp Cys Leu Pro Cys Val Phe Leu Val Asp Phe Glu Phe Gly Cys Ala
             180                 185                 190        
 Thr Ser Tyr Ile Leu Pro Glu Leu Gln Asp Gly Leu Ser Phe His Val
         195                 200                 205            
 Ser Ile Ala Lys Asn Asp Thr Ile Tyr Ile Leu Gly Gly His Ser Leu
     210                 215                 220                
 Ala Asn Asn Ile Arg Pro Ala Asn Leu Tyr Arg Ile Arg Val Asp Leu
 225                 230                 235                 240
 Pro Leu Gly Ser Pro Ala Val Asn Cys Thr Val Leu Pro Gly Gly Ile
                 245                 250                 255    
 Ser Val Ser Ser Ala Ile Leu Thr Gln Thr Asn Asn Asp Glu Phe Val
             260                 265                 270        
 Ile Val Gly Gly Tyr Gln Leu Glu Asn Gln Lys Arg Met Ile Cys Asn
         275                 280                 285            
 Ile Ile Ser Leu Glu Asp Asn Lys Ile Glu Ile Arg Glu Met Glu Thr
     290                 295                 300                
 Pro Asp Trp Thr Pro Asp Ile Lys His Ser Lys Ile Trp Phe Gly Ser
 305                 310                 315                 320
 Asn Met Gly Asn Gly Thr Val Phe Leu Gly Ile Pro Gly Asp Asn Lys
                 325                 330                 335    
 Gln Val Val Ser Glu Gly Phe Tyr Phe Tyr Met Leu Lys Cys Ala Glu
             340                 345                 350        
 Asp Asp Thr Asn Glu Glu Gln Thr Thr Phe Thr Asn Ser Gln Thr Ser
         355                 360                 365            
 Thr Glu Asp Pro Gly Asp Ser Thr Pro Phe Glu Asp Ser Glu Glu Phe
     370                 375                 380                
 Cys Phe Ser Ala Glu Ala Asn Ser Phe Asp Gly Asp Asp Glu Phe Asp
 385                 390                 395                 400
 Thr Tyr Asn Glu Asp Asp Glu Glu Asp Glu Ser Glu Thr Gly Tyr Trp
                 405                 410                 415    
 Ile Thr Cys Cys Pro Thr Cys Asp Val Asp Ile Asn Thr Trp Val Pro
             420                 425                 430        
 Phe Tyr Ser Thr Glu Leu Asn Lys Pro Ala Met Ile Tyr Cys Ser His
         435                 440                 445            
 Gly Asp Gly His Trp Val His Ala Gln Cys Met Asp Leu Ala Glu Arg
     450                 455                 460                
 Thr Leu Ile His Leu Ser Ala Gly Ser Asn Lys Tyr Tyr Cys Asn Glu
 465                 470                 475                 480
 His Val Glu Ile Ala Arg Ala Leu His Thr Pro Gln Arg Val Leu Pro
                 485                 490                 495    
 Leu Lys Lys Pro Pro Met Lys Ser Leu Arg Lys Lys Gly Ser Gly Lys
             500                 505                 510        
 Ile Leu Thr Pro Ala Lys Lys Ser Phe Leu Arg Arg Leu Phe Asp
         515                 520                 525        



      <210> 1026
      <211> 326
      <212> PRT
      <213> Homo sapiens


      <400> 1026
 Met Ala Leu Pro Lys Asp Ala Ile Pro Ser Leu Ser Glu Cys Gln Cys
   1               5                  10                  15    
 Gly Ile Cys Met Glu Ile Leu Val Glu Pro Val Thr Leu Pro Cys Asn
              20                  25                  30        
 His Thr Leu Cys Lys Pro Cys Phe Gln Ser Thr Val Glu Lys Ala Ser
          35                  40                  45            
 Leu Cys Cys Pro Phe Cys Arg Arg Arg Val Ser Ser Trp Thr Arg Tyr
      50                  55                  60                
 His Thr Arg Arg Asn Ser Leu Val Asn Val Glu Leu Trp Thr Ile Ile
  65                  70                  75                  80
 Gln Lys His Tyr Pro Arg Glu Cys Lys Leu Arg Ala Ser Gly Gln Glu
                  85                  90                  95    
 Ser Glu Glu Val Ala Asp Asp Tyr Gln Pro Val Arg Leu Leu Ser Lys
             100                 105                 110        
 Pro Gly Glu Leu Arg Arg Glu Tyr Glu Glu Glu Ile Ser Lys Val Ala
         115                 120                 125            
 Ala Glu Arg Arg Ala Ser Glu Glu Glu Glu Asn Lys Ala Ser Glu Glu
     130                 135                 140                
 Tyr Ile Gln Arg Leu Leu Ala Glu Glu Glu Glu Glu Glu Lys Arg Gln
 145                 150                 155                 160
 Ala Glu Lys Arg Arg Arg Ala Met Glu Glu Gln Leu Lys Ser Asp Glu
                 165                 170                 175    
 Glu Leu Ala Arg Lys Leu Ser Ile Asp Ile Asn Asn Phe Cys Glu Gly
             180                 185                 190        
 Ser Ile Ser Ala Ser Pro Leu Asn Ser Arg Lys Ser Asp Pro Val Thr
         195                 200                 205            
 Pro Lys Ser Glu Lys Lys Ser Lys Asn Lys Gln Arg Asn Thr Gly Asp
     210                 215                 220                
 Ile Gln Lys Tyr Leu Thr Pro Lys Ser Gln Phe Gly Ser Ala Ser His
 225                 230                 235                 240
 Ser Glu Ala Val Gln Glu Val Arg Lys Asp Ser Val Ser Lys Asp Ile
                 245                 250                 255    
 Asp Ser Ser Asp Arg Lys Ser Pro Thr Gly Gln Asp Thr Glu Ile Glu
             260                 265                 270        
 Asp Met Pro Thr Leu Ser Pro Gln Ile Ser Leu Gly Val Gly Glu Gln
         275                 280                 285            
 Gly Ala His Ser Ser Ile Glu Pro Pro Met Pro Trp Ile Cys Ala Cys
     290                 295                 300                
 Gly Ala Glu Trp Tyr His Glu Gly Asn Val Lys Ser Arg Pro Ser Tyr
 305                 310                 315                 320
 Leu Gly Lys Glu Phe Met
                 325    



      <210> 1027
      <211> 225
      <212> PRT
      <213> Homo sapiens


      <400> 1027
 Met Ala Thr Phe Ile Gly Ala Ala Val Ser Asn Ser Ser Arg Gly Thr
   1               5                  10                  15    
 Ala Pro Cys Gly Ile Gly Leu Pro Pro Arg Gln His Ala Gln Ser Ser
              20                  25                  30        
 Ser Ser Gly Val Ile Leu Ser Ser Tyr Leu Tyr Pro Leu Leu Ile Thr
          35                  40                  45            
 Cys Lys Leu Arg Gly Arg Leu Phe Arg Ile Phe Trp Thr Lys Asp Asp
      50                  55                  60                
 Thr Ser Arg Pro Leu Pro Trp Lys Gly Val Val Thr Phe Arg Cys Cys
  65                  70                  75                  80
 His His Cys Gly Lys Leu Thr Trp Cys Cys Trp Val Cys Leu Met Glu
                  85                  90                  95    
 Arg Cys Phe His Cys Phe Pro Val His Leu Val Phe Asn Leu Val Gln
             100                 105                 110        
 Ser Phe Ser Pro Thr Ser Gly Val Glu Ser Cys Leu Leu Pro Gln Cys
         115                 120                 125            
 Asp Lys Cys Trp Pro Met Val Tyr Arg Ser Cys Asp Ala Ser Arg Gly
     130                 135                 140                
 Leu Val Asn Ala Cys Ile Leu Gly Phe Val Leu Leu Glu Cys Ser Phe
 145                 150                 155                 160
 Val Gly Ala Leu Asn Asn Tyr Val Arg Ser Leu Ala Thr Leu Leu Glu
                 165                 170                 175    
 Arg Thr His Gly Gly Lys Arg Leu Lys Leu Cys Glu Glu Ser Gln Ala
             180                 185                 190        
 Ser His Pro Ser Phe Ser Ala Glu Pro Arg His Gln Pro Thr Cys Gln
         195                 200                 205            
 Leu Asn Ala Thr Val Arg Val Ile Thr Ser Lys Ile Thr Arg Lys Thr
     210                 215                 220                
 Thr
 225



      <210> 1028
      <211> 162
      <212> PRT
      <213> Homo sapiens


      <400> 1028
 Met Phe Ile Phe Ser Ser Arg Arg Thr Arg Ala Gly Val Leu His Val
   1               5                  10                  15    
 His Val Ser Ala Gln Gly Val His Val Gln Met Cys His Arg Phe Met
              20                  25                  30        
 Phe Ser Ala Arg Arg Thr Arg Ala Gly Val Leu His Val His Phe Arg
          35                  40                  45            
 Leu Lys Ala Tyr Thr Cys Arg Cys Ala Thr Cys Ser Phe Ser Val Gln
      50                  55                  60                
 Gly Val His Val Gln Val Cys Tyr Val Phe Ile Phe Gly Ser Arg Arg
  65                  70                  75                  80
 Thr Arg Ala Gly Val Pro His Val Tyr Phe Arg Phe Lys Ala Tyr Thr
                  85                  90                  95    
 Cys Arg Cys Val Thr Cys Ser Phe Ser Ala Gln Gly Val His Val Gln
             100                 105                 110        
 Val Cys Tyr Val Phe Ile Phe Gly Ser Arg Arg Thr Arg Ala Gly Val
         115                 120                 125            
 Leu Arg Val His Phe Arg Leu Lys Ala Tyr Thr Cys Arg Cys Val Thr
     130                 135                 140                
 Trp Val Asn Gln Val Ser Leu Gly Phe Gly Val Gln Ile Ile Leu Leu
 145                 150                 155                 160
 Pro Arg
        



      <210> 1029
      <211> 281
      <212> PRT
      <213> Homo sapiens


      <400> 1029
 Met Ala Thr Ser Thr Met Ser Val Cys Ser Ser Ala Tyr Ser Asp Ser
   1               5                  10                  15    
 Trp Gln Val Asp Ala Cys Pro Glu Ser Cys Cys Glu Pro Pro Cys Cys
              20                  25                  30        
 Ala Pro Ser Cys Cys Ala Pro Ala Pro Cys Leu Thr Leu Val Cys Thr
          35                  40                  45            
 Pro Val Ser Cys Val Ser Ser Pro Cys Cys Gln Ala Ala Cys Glu Pro
      50                  55                  60                
 Ser Pro Cys Gln Ser Gly Cys Thr Ser Ser Cys Thr Pro Ser Cys Cys
  65                  70                  75                  80
 Gln Gln Ser Ser Cys Gln Pro Ala Tyr Cys Thr Ser Ser Pro Cys Gln
                  85                  90                  95    
 Gln Ala Cys Cys Val Pro Val Cys Cys Lys Pro Val Cys Cys Val Pro
             100                 105                 110        
 Val Cys Cys Gly Ala Ser Ser Cys Cys Gln Gln Ser Ser Tyr Gln Pro
         115                 120                 125            
 Ala Cys Cys Ala Ser Ser Ser Cys Gln Pro Ala Cys Cys Val Pro Val
     130                 135                 140                
 Cys Cys Lys Pro Val Cys Cys Ala Pro Thr Cys Ser Glu Asp Ser Tyr
 145                 150                 155                 160
 Ser Cys Cys Gln Gln Ser Ser Cys Gln Pro Ala Cys Cys Thr Ser Ser
                 165                 170                 175    
 Pro Cys Gln Gln Ser Tyr Cys Val Pro Val Cys Cys Lys Pro Val Cys
             180                 185                 190        
 Cys Lys Pro Ile Cys Cys Val Pro Val Cys Ser Gly Ala Ser Ser Leu
         195                 200                 205            
 Cys Cys Gln Gln Ser Gly Cys Gln Pro Ala Cys Cys Thr Thr Ser Cys
     210                 215                 220                
 Cys Arg Pro Ser Ser Ser Val Ser Leu Leu Cys Arg Pro Val Cys Arg
 225                 230                 235                 240
 Pro Ala Cys Cys Val Pro Val Ser Ser Cys Cys Ala Pro Ala Ser Ser
                 245                 250                 255    
 Tyr Gln Pro Ser Cys Cys Arg Pro Ala Ser Cys Val Ser Leu Leu Cys
             260                 265                 270        
 Arg Pro Val Cys Ser Arg Leu Ala Cys
         275                 280    



      <210> 1030
      <211> 83
      <212> PRT
      <213> Homo sapiens


      <400> 1030
 Met Ile Leu Ile Leu Ile Leu Glu His Ile Val Thr Ser Lys Arg Asn
   1               5                  10                  15    
 Pro Lys Pro Val Thr Val Pro Ala Phe Leu Pro Pro Cys Leu Thr Ser
              20                  25                  30        
 Phe Ser Cys Ser Gly Ala Ser Phe Ser Leu Phe Gly Gly Arg Arg Gly
          35                  40                  45            
 Trp Gln His Gly Ser Cys Cys Ser Thr Ile Pro Leu Phe Pro Thr Leu
      50                  55                  60                
 Asn Ser Leu Gly Gln Gly Leu Ile Gly Pro Ala Tyr Ile Gly Ala Pro
  65                  70                  75                  80
 Leu Ala Arg
            



      <210> 1031
      <211> 165
      <212> PRT
      <213> Homo sapiens


      <400> 1031
 Met Val Asn Ser Val Val Phe Phe Asp Ile Thr Val Asp Gly Lys Pro
   1               5                  10                  15    
 Leu Gly Arg Ile Ser Ile Lys Leu Phe Ala Asp Lys Ile Leu Lys Thr
              20                  25                  30        
 Ala Glu Asn Phe Arg Ala Leu Ser Thr Gly Glu Lys Gly Phe Arg Tyr
          35                  40                  45            
 Lys Gly Ser Cys Phe His Arg Ile Ile Pro Gly Phe Met Cys Gln Gly
      50                  55                  60                
 Gly Asp Phe Thr Arg His Asn Gly Thr Gly Gly Lys Ser Ile Tyr Gly
  65                  70                  75                  80
 Glu Lys Phe Glu Asp Glu Asn Phe Ile Leu Lys His Thr Gly Pro Gly
                  85                  90                  95    
 Ile Leu Ser Met Ala Asn Ala Gly Pro Asn Thr Asn Gly Ser Gln Phe
             100                 105                 110        
 Phe Ile Cys Thr Ala Lys Thr Glu Trp Leu Asp Gly Lys His Val Val
         115                 120                 125            
 Phe Gly Lys Val Lys Glu Gly Met Asn Ile Val Glu Ala Met Glu Arg
     130                 135                 140                
 Phe Gly Ser Arg Asn Gly Lys Thr Ser Thr Lys Ile Thr Ile Ala Asp
 145                 150                 155                 160
 Cys Gly Gln His Arg
                 165



      <210> 1032
      <211> 120
      <212> PRT
      <213> Homo sapiens


      <400> 1032
 Met Lys Val Asp Ile Asn Leu Gln Lys Val Asp Ile Asp Gln Cys Ser
   1               5                  10                  15    
 Ser Asp Gly Trp Phe Ser Gly Thr His Lys Cys His Leu Asn Asn Ser
              20                  25                  30        
 Glu Cys Met Pro Ile Lys Gly Leu Gly Phe Val Leu Gly Ala Tyr Glu
          35                  40                  45            
 Cys Ile Cys Lys Ala Gly Phe Tyr His Pro Gly Val Leu Pro Val Asn
      50                  55                  60                
 Asn Phe Arg Arg Arg Gly Pro Asp Gln His Ile Ser Gly Ser Thr Lys
  65                  70                  75                  80
 Asp Val Ser Glu Glu Ala Tyr Val Cys Leu Pro Cys Arg Glu Gly Cys
                  85                  90                  95    
 Pro Phe Cys Ala Asp Asp Ser Pro Cys Phe Val Gln Glu Asp Lys Tyr
             100                 105                 110        
 Leu Arg Leu Ala Ile Ile Ala Phe
         115                 120



      <210> 1033
      <211> 115
      <212> PRT
      <213> Homo sapiens


      <400> 1033
 Met Thr Ala Ile Arg Leu Arg Glu Phe Ile Glu Arg Arg Pro Val Ile
   1               5                  10                  15    
 Pro Pro Ser Ile Phe Ile Ala His Gln Gly Arg Asp Val Gln Gly Tyr
              20                  25                  30        
 Tyr Pro Gly Gln Leu Ala Arg Leu His Phe Asp His Ser Ala Lys Arg
          35                  40                  45            
 Ala Pro Arg His Ser Lys Pro Ala Glu Pro Trp Tyr Lys Glu Thr Thr
      50                  55                  60                
 Tyr Arg Arg Asp Tyr Ser Leu Pro Phe Tyr Glu Ile Asp Trp Asn Gln
  65                  70                  75                  80
 Lys Leu Ala Thr Val Ser Leu Asn Pro Arg Pro Leu Asn Ser Leu Pro
                  85                  90                  95    
 Glu Leu Tyr Cys Cys Glu Glu Arg Ser Ser Phe Glu Arg Asn Ala Phe
             100                 105                 110        
 Lys Leu Lys
         115



      <210> 1034
      <211> 117
      <212> PRT
      <213> Homo sapiens


      <400> 1034
 Met Arg Asn Ala Gly Ala Pro Pro Ser Ser Trp Ala Thr Arg Cys Cys
   1               5                  10                  15    
 Cys Ser Thr Ala Cys Ala Ser Ser Pro Arg Arg Thr Ala Ser Pro Ser
              20                  25                  30        
 Ser Pro Gly Glu Pro Pro Arg Ala Arg Arg Leu Ala Cys Ser Lys Arg
          35                  40                  45            
 Val Cys Ser Asn Pro Gly Pro Arg Cys Leu Leu Arg Val Pro Pro Glu
      50                  55                  60                
 Gly Lys Gly Pro Arg Pro Pro Arg Ala Arg Pro Glu Lys Ala Pro Leu
  65                  70                  75                  80
 Pro Pro Val Leu Gly Pro Asp Arg Ser Pro Pro Leu Pro Ala Pro Ala
                  85                  90                  95    
 Glu Cys Phe Ser Pro Leu Ile Lys Ile Ile Arg Leu Gln Lys Lys Lys
             100                 105                 110        
 Lys Lys Val Pro Phe
         115        



      <210> 1035
      <211> 576
      <212> PRT
      <213> Homo sapiens


      <400> 1035
 Met Asp Ser Val Ala Phe Glu Asp Val Ser Val Ser Phe Ser Gln Glu
   1               5                  10                  15    
 Glu Trp Ala Leu Leu Ala Pro Ser Gln Lys Lys Leu Tyr Arg Asp Val
              20                  25                  30        
 Met Gln Glu Thr Phe Lys Asn Leu Ala Ser Ile Gly Glu Lys Trp Glu
          35                  40                  45            
 Asp Pro Asn Val Glu Asp Gln His Lys Asn Gln Gly Arg Asn Leu Arg
      50                  55                  60                
 Ser His Thr Gly Glu Arg Leu Cys Glu Gly Lys Glu Gly Ser Gln Cys
  65                  70                  75                  80
 Ala Glu Asn Phe Ser Pro Asn Leu Ser Val Thr Lys Lys Thr Ala Gly
                  85                  90                  95    
 Val Lys Pro Tyr Glu Cys Thr Ile Cys Gly Lys Ala Phe Met Arg Leu
             100                 105                 110        
 Ser Ser Leu Thr Arg His Met Arg Ser His Thr Gly Tyr Glu Leu Phe
         115                 120                 125            
 Glu Lys Pro Tyr Lys Cys Lys Glu Cys Glu Lys Ala Phe Ser Tyr Leu
     130                 135                 140                
 Lys Ser Phe Gln Arg His Glu Arg Ser His Thr Gly Glu Lys Pro Tyr
 145                 150                 155                 160
 Lys Cys Lys Gln Cys Gly Lys Thr Phe Ile Tyr His Gln Pro Phe Gln
                 165                 170                 175    
 Arg His Glu Arg Thr His Ile Gly Glu Lys Pro Tyr Glu Cys Lys Gln
             180                 185                 190        
 Cys Gly Lys Ala Leu Ser Cys Ser Ser Ser Leu Arg Val His Glu Arg
         195                 200                 205            
 Ile His Thr Gly Glu Lys Pro Tyr Glu Cys Lys Gln Cys Gly Lys Ala
     210                 215                 220                
 Phe Ser Cys Ser Ser Ser Ile Arg Val His Glu Arg Thr His Thr Gly
 225                 230                 235                 240
 Glu Lys Pro Tyr Ala Cys Lys Glu Cys Gly Lys Ala Phe Ile Ser His
                 245                 250                 255    
 Thr Ser Val Leu Thr His Met Ile Thr His Asn Gly Asp Arg Pro Tyr
             260                 265                 270        
 Lys Cys Lys Glu Cys Gly Lys Ala Phe Ile Phe Pro Ser Phe Leu Arg
         275                 280                 285            
 Val His Glu Arg Ile His Thr Gly Glu Lys Pro Tyr Lys Cys Lys Gln
     290                 295                 300                
 Cys Gly Lys Ala Phe Arg Cys Ser Thr Ser Ile Gln Ile His Glu Arg
 305                 310                 315                 320
 Ile His Thr Gly Glu Lys Pro Tyr Lys Cys Lys Glu Cys Gly Lys Ser
                 325                 330                 335    
 Phe Ser Ala Arg Pro Ala Phe Arg Val His Val Arg Val His Thr Gly
             340                 345                 350        
 Glu Lys Pro Tyr Lys Cys Lys Glu Cys Gly Lys Ala Phe Ser Arg Ile
         355                 360                 365            
 Ser Tyr Phe Arg Ile His Glu Arg Thr His Thr Gly Glu Lys Pro Tyr
     370                 375                 380                
 Glu Cys Lys Lys Cys Gly Lys Thr Phe Asn Tyr Pro Leu Asp Leu Lys
 385                 390                 395                 400
 Ile His Lys Arg Asn His Thr Gly Glu Lys Pro Tyr Glu Cys Lys Glu
                 405                 410                 415    
 Cys Ala Lys Thr Phe Ile Ser Leu Glu Asn Phe Arg Arg His Met Ile
             420                 425                 430        
 Thr His Thr Gly Asp Gly Pro Tyr Lys Cys Arg Asp Cys Gly Lys Val
         435                 440                 445            
 Phe Ile Phe Pro Ser Ala Leu Arg Thr His Glu Arg Thr His Thr Gly
     450                 455                 460                
 Glu Lys Pro Tyr Glu Cys Lys Gln Cys Gly Lys Ala Phe Ser Cys Ser
 465                 470                 475                 480
 Ser Tyr Ile Arg Ile His Lys Arg Thr His Thr Gly Glu Lys Pro Tyr
                 485                 490                 495    
 Glu Cys Lys Glu Cys Gly Lys Ala Phe Ile Tyr Pro Thr Ser Phe Gln
             500                 505                 510        
 Gly His Met Arg Met His Thr Gly Glu Lys Pro Tyr Lys Cys Lys Glu
         515                 520                 525            
 Cys Gly Lys Ala Phe Ser Leu His Ser Ser Phe Gln Arg His Thr Arg
     530                 535                 540                
 Ile His Asn Tyr Glu Lys Pro Leu Glu Cys Lys Gln Cys Gly Lys Ala
 545                 550                 555                 560
 Phe Ser Val Ser Thr Ser Leu Lys Lys His Met Arg Met His Asn Arg
                 565                 570                 575    





      <210> 1036
      <211> 111
      <212> PRT
      <213> Homo sapiens


      <400> 1036
 Met Gly Thr Thr Ile Ile Asp Leu Gly Gly Asp Thr Ala Thr Pro Tyr
   1               5                  10                  15    
 Gln Leu Leu Ser Trp Ala Ser Ser Phe Leu Asn Ala His Trp Pro Leu
              20                  25                  30        
 Arg His Phe Leu Val Asn Leu Ile Pro Gln Leu Arg Lys Pro Arg Leu
          35                  40                  45            
 Gly Thr Gly Lys Gly Ser Asp Pro Thr Ser Pro Ile Leu Leu Val Glu
      50                  55                  60                
 Gly Pro Arg Leu Asp Pro Gln Leu Cys Ser Cys Phe Glu Ser Pro Cys
  65                  70                  75                  80
 Cys Pro Gln Asp Gln Ile Ser Lys Gln Ala Asp Met Gly Gly Ser Glu
                  85                  90                  95    
 Ser Pro Gln Pro Arg Thr Phe Leu Ser Pro Asn Asp Thr Lys Gly
             100                 105                 110    



      <210> 1037
      <211> 180
      <212> PRT
      <213> Homo sapiens


      <400> 1037
 Met Val His Val Ser Asn Arg Ser Ile Gln Gly Met Asn Ile Leu Phe
   1               5                  10                  15    
 Ser Ser Trp Ala Val Val Leu Met Val Met Gly Ile Thr Leu Asp Lys
              20                  25                  30        
 Trp Val Glu Leu Ile Ser Glu Asp Glu Arg Ala Lys Met Asn His Ser
          35                  40                  45            
 Pro Trp Met Met Cys Cys Pro Ala Leu Trp Pro Glu Asp Asp Leu Lys
      50                  55                  60                
 Val Val Arg Ile Met Met Thr Ser Ser Leu Gly Leu Ser Phe Leu Leu
  65                  70                  75                  80
 Asn Leu Ile Leu Gly Met Lys Phe Thr Tyr Leu Ile Pro Gln Asn Lys
                  85                  90                  95    
 Tyr Ile Gln Leu Phe Thr Thr Ile Leu Ser Phe Phe Ser Gly Val Leu
             100                 105                 110        
 Ser Leu Leu Glu Cys Lys Leu Ser Thr Ser Ser Cys Thr Cys Leu Asn
         115                 120                 125            
 Ile His Lys Ser Asp Asn Glu Cys Lys Glu Ser Glu Asn Ser Ile Glu
     130                 135                 140                
 Asp Ile Ser Leu Pro Glu Cys Thr Ala Met Pro Arg Ser Ile Val Arg
 145                 150                 155                 160
 Ala His Thr Val Asn Ser Leu Asn Lys Lys Val Gln Thr Arg His Val
                 165                 170                 175    
 Thr Trp Ala Leu
             180



      <210> 1038
      <211> 1101
      <212> PRT
      <213> Homo sapiens


      <400> 1038
 Met Gln Phe Gly Phe Val Ala Ile Tyr Leu Ser Glu Ser Phe Ile Arg
   1               5                  10                  15    
 Gly Phe Met Thr Ala Ala Gly Leu Gln Ile Leu Ile Ser Val Leu Lys
              20                  25                  30        
 Tyr Ile Phe Gly Leu Thr Ile Pro Ser Tyr Thr Gly Pro Gly Ser Ile
          35                  40                  45            
 Val Phe Thr Phe Ile Asp Ile Cys Lys Asn Leu Pro His Thr Asn Ile
      50                  55                  60                
 Ala Ser Leu Ile Phe Ala Leu Ile Ser Gly Ala Phe Leu Val Leu Val
  65                  70                  75                  80
 Lys Glu Leu Asn Ala Arg Tyr Met His Lys Ile Arg Phe Pro Ile Pro
                  85                  90                  95    
 Thr Glu Met Ile Val Val Val Val Ala Thr Ala Ile Ser Gly Gly Cys
             100                 105                 110        
 Lys Met Pro Lys Lys Tyr His Met Gln Ile Val Gly Glu Ile Gln Arg
         115                 120                 125            
 Gly Phe Pro Thr Pro Val Ser Pro Val Val Ser Gln Trp Lys Asp Met
     130                 135                 140                
 Ile Gly Thr Ala Phe Ser Leu Ala Ile Val Ser Tyr Val Ile Asn Leu
 145                 150                 155                 160
 Ala Met Gly Arg Thr Leu Ala Asn Lys His Gly Tyr Asp Val Asp Ser
                 165                 170                 175    
 Asn Gln Glu Met Ile Ala Leu Gly Cys Ser Asn Phe Phe Gly Ser Phe
             180                 185                 190        
 Phe Lys Ile His Val Ile Cys Cys Ala Leu Ser Val Thr Leu Ala Val
         195                 200                 205            
 Asp Gly Ala Gly Gly Lys Ser Gln Ser Val Leu Gly Ala Leu Ile Ala
     210                 215                 220                
 Val Asn Leu Lys Asn Ser Leu Lys Gln Leu Thr Asp Pro Tyr Tyr Leu
 225                 230                 235                 240
 Trp Arg Lys Ser Lys Leu Asp Cys Leu Val Asn Ala Pro Asp Met Ser
                 245                 250                 255    
 Gln Pro Arg Pro Arg Tyr Val Val Asp Arg Ala Ala Tyr Ser Leu Thr
             260                 265                 270        
 Leu Phe Asp Asp Glu Phe Glu Lys Lys Asp Arg Thr Tyr Pro Val Gly
         275                 280                 285            
 Glu Lys Leu Arg Asn Ala Phe Arg Cys Ser Ser Ala Lys Ile Lys Ala
     290                 295                 300                
 Val Val Phe Gly Leu Leu Pro Val Leu Ser Trp Leu Pro Lys Tyr Lys
 305                 310                 315                 320
 Ile Lys Asp Tyr Ile Ile Pro Asp Leu Leu Gly Gly Leu Ser Gly Gly
                 325                 330                 335    
 Ser Ile Gln Val Pro Gln Gly Met Ala Phe Ala Leu Leu Ala Asn Leu
             340                 345                 350        
 Pro Ala Val Asn Gly Leu Tyr Ser Ser Phe Phe Pro Leu Leu Thr Tyr
         355                 360                 365            
 Phe Phe Leu Gly Gly Val His Gln Met Val Pro Gly Thr Phe Ala Val
     370                 375                 380                
 Ile Ser Ile Leu Val Gly Asn Ile Cys Leu Gln Leu Ala Pro Glu Ser
 385                 390                 395                 400
 Lys Phe Gln Val Phe Asn Asn Ala Thr Asn Glu Ser Tyr Val Asp Thr
                 405                 410                 415    
 Ala Ala Met Glu Ala Glu Arg Leu His Val Ser Ala Thr Leu Ala Cys
             420                 425                 430        
 Leu Thr Ala Ile Ile Gln Met Gly Leu Gly Phe Met Gln Phe Gly Phe
         435                 440                 445            
 Val Ala Ile Tyr Leu Ser Glu Ser Phe Ile Arg Gly Phe Met Thr Ala
     450                 455                 460                
 Ala Gly Leu Gln Ile Leu Ile Ser Val Leu Lys Tyr Ile Phe Gly Leu
 465                 470                 475                 480
 Thr Ile Pro Ser Tyr Thr Gly Pro Gly Ser Ile Val Phe Thr Phe Ile
                 485                 490                 495    
 Asp Ile Cys Lys Asn Leu Pro His Thr Asn Ile Ala Ser Leu Ile Phe
             500                 505                 510        
 Ala Leu Ile Ser Gly Ala Phe Leu Val Leu Val Lys Glu Leu Asn Ala
         515                 520                 525            
 Arg Tyr Met His Lys Ile Arg Phe Pro Ile Pro Thr Glu Met Ile Val
     530                 535                 540                
 Val Val Val Ala Thr Ala Ile Ser Gly Gly Cys Lys Met Pro Lys Lys
 545                 550                 555                 560
 Tyr His Met Gln Ile Val Gly Glu Ile Gln Arg Gly Phe Pro Thr Pro
                 565                 570                 575    
 Val Ser Pro Val Val Ser Gln Trp Lys Asp Met Ile Gly Thr Ala Phe
             580                 585                 590        
 Ser Leu Ala Ile Val Ser Tyr Val Ile Asn Leu Ala Met Gly Arg Thr
         595                 600                 605            
 Leu Ala Asn Lys His Gly Tyr Asp Val Asp Ser Asn Gln Glu Met Ile
     610                 615                 620                
 Ala Leu Gly Cys Ser Asn Phe Phe Gly Ser Phe Phe Lys Ile His Val
 625                 630                 635                 640
 Ile Cys Cys Ala Leu Ser Val Thr Leu Ala Val Asp Gly Ala Gly Gly
                 645                 650                 655    
 Lys Ser Gln Val Ala Ser Leu Cys Val Ser Leu Val Val Met Ile Thr
             660                 665                 670        
 Met Leu Val Leu Gly Ile Tyr Leu Tyr Pro Leu Pro Lys Ser Val Leu
         675                 680                 685            
 Gly Ala Leu Ile Ala Val Asn Leu Lys Asn Ser Leu Lys Gln Leu Thr
     690                 695                 700                
 Asp Pro Tyr Tyr Leu Trp Arg Lys Ser Lys Leu Asp Cys Cys Ile Trp
 705                 710                 715                 720
 Val Val Ser Phe Leu Ser Ser Phe Phe Leu Ser Leu Pro Tyr Gly Val
                 725                 730                 735    
 Ala Val Gly Val Ala Phe Ser Val Leu Val Val Val Phe Gln Thr Gln
             740                 745                 750        
 Phe Arg Asn Gly Tyr Ala Leu Ala Gln Val Met Asp Thr Asp Ile Tyr
         755                 760                 765            
 Val Asn Pro Lys Thr Tyr Asn Arg Ala Gln Asp Ile Gln Gly Ile Lys
     770                 775                 780                
 Ile Ile Thr Tyr Cys Ser Pro Leu Tyr Phe Ala Asn Ser Glu Ile Phe
 785                 790                 795                 800
 Arg Gln Lys Val Ile Ala Lys Thr Gly Met Asp Pro Gln Lys Val Leu
                 805                 810                 815    
 Leu Ala Lys Gln Lys Tyr Leu Lys Lys Gln Glu Lys Arg Arg Met Arg
             820                 825                 830        
 Pro Thr Gln Gln Arg Arg Ser Leu Phe Met Lys Thr Lys Thr Val Ser
         835                 840                 845            
 Leu Gln Glu Leu Gln Gln Asp Phe Glu Asn Ala Pro Pro Thr Asp Pro
     850                 855                 860                
 Asn Asn Asn Gln Thr Pro Ala Asn Gly Thr Ser Val Ser Tyr Ile Thr
 865                 870                 875                 880
 Phe Ser Pro Asp Ser Ser Ser Pro Ala Gln Ser Glu Pro Pro Ala Ser
                 885                 890                 895    
 Ala Glu Ala Pro Gly Glu Pro Ser Asp Met Leu Ala Ser Val Pro Pro
             900                 905                 910        
 Phe Val Thr Phe His Thr Leu Ile Leu Asp Met Ser Gly Val Ser Phe
         915                 920                 925            
 Val Asp Leu Met Gly Ile Lys Ala Leu Ala Lys Leu Ser Ser Thr Tyr
     930                 935                 940                
 Gly Lys Ile Gly Val Lys Val Phe Leu Val Asn Ile His Ala Gln Val
 945                 950                 955                 960
 Tyr Asn Asp Ile Ser His Gly Gly Val Phe Glu Asp Gly Ser Leu Glu
                 965                 970                 975    
 Cys Lys His Val Phe Pro Ser Ile His Asp Ala Val Leu Phe Ala Gln
             980                 985                 990        
 Ala Asn Ala Arg Asp Val Thr Pro Gly His Asn Phe Gln Gly Ala Pro
         995                1000                1005            
 Gly Asp Ala Glu Leu Ser Leu Tyr Asp Ser Glu Glu Asp Ile Arg Ser
    1010                1015                1020                
 Tyr Trp Asp Leu Glu Gln Ala Leu Ala Ala Met Asp Lys Pro Pro Ala
1025                1030                1035                1040
 His Ser Thr Pro Pro Thr Ser Ala Leu Ser Leu Ala Ala Glu Gly His
                1045                1050                1055    
 Leu Asp Phe Gln Leu Leu Arg Val Ser Gln Lys Gln Lys Asp Lys Tyr
            1060                1065                1070        
 Asn Cys Ala Gly Leu Leu Tyr Lys Leu Gln Lys Val Ser Gln Ser Pro
        1075                1080                1085            
 His Gly Ser Val Ser Asp Gly Val Arg Leu Ser Arg Thr
    1090                1095                1100    



      <210> 1039
      <211> 202
      <212> PRT
      <213> Homo sapiens


      <400> 1039
 Met Glu Leu Ser Asp Val Thr Leu Ile Glu Gly Val Gly Asn Glu Val
   1               5                  10                  15    
 Met Val Val Ala Gly Val Val Val Leu Ile Leu Ala Leu Val Leu Ala
              20                  25                  30        
 Trp Leu Ser Thr Tyr Val Ala Asp Ser Gly Ser Asn Gln Leu Leu Gly
          35                  40                  45            
 Ala Ile Val Pro Gly Leu Ile Thr Val Arg Leu Lys Phe Leu Asn Asp
      50                  55                  60                
 Thr Glu Glu Leu Ala Val Ala Arg Pro Glu Asp Thr Val Gly Ala Leu
  65                  70                  75                  80
 Lys Ser Lys Tyr Phe Pro Gly Gln Glu Ser Gln Met Lys Leu Ile Tyr
                  85                  90                  95    
 Gln Gly Arg Leu Leu Gln Asp Pro Ala Arg Thr Leu Arg Ser Leu Asn
             100                 105                 110        
 Ile Thr Asp Asn Cys Val Ile His Cys His Arg Ser Pro Pro Gly Ser
         115                 120                 125            
 Ala Val Pro Gly Pro Ser Ala Ser Leu Ala Pro Ser Ala Thr Glu Pro
     130                 135                 140                
 Pro Ser Leu Gly Val Asn Val Gly Ser Leu Met Val Pro Val Phe Val
 145                 150                 155                 160
 Val Leu Leu Gly Val Val Trp Tyr Phe Arg Ile Asn Tyr Arg Gln Phe
                 165                 170                 175    
 Phe Thr Ala Pro Ala Thr Val Ser Leu Val Gly Val Thr Val Phe Phe
             180                 185                 190        
 Ser Phe Leu Val Phe Gly Met Tyr Gly Arg
         195                 200        



      <210> 1040
      <211> 157
      <212> PRT
      <213> Homo sapiens


      <400> 1040
 Met Ala Thr Ala Ala Gly Ala Thr Tyr Phe Gln Arg Gly Ser Leu Phe
   1               5                  10                  15    
 Trp Phe Thr Val Ile Thr Leu Ser Phe Gly Tyr Tyr Thr Arg Met Val
              20                  25                  30        
 Lys Ser Glu Ala Ser Asn Ala Ala Thr Ala Tyr Phe Arg Pro Ala Arg
          35                  40                  45            
 Pro Leu Pro Ser Leu Val Thr Val Leu Gly Leu Gly Tyr Phe Ala Trp
      50                  55                  60                
 Val Val Phe Trp Pro Gln Ser Ile Pro Tyr Gln Asn Leu Gly Pro Leu
  65                  70                  75                  80
 Gly Pro Phe Thr Gln Tyr Leu Val Asp His His His Thr Leu Leu Cys
                  85                  90                  95    
 Asn Gly Tyr Trp Leu Ala Trp Leu Ile His Val Gly Glu Ser Leu Tyr
             100                 105                 110        
 Ala Ile Val Leu Cys Lys His Lys Gly Ile Thr Ser Gly Arg Ala Gln
         115                 120                 125            
 Leu Leu Trp Phe Leu Gln Thr Phe Phe Phe Gly Ile Ala Ser Leu Thr
     130                 135                 140                
 Ile Leu Ile Ala Tyr Lys Arg Lys Arg Gln Lys Gln Thr
 145                 150                 155        



      <210> 1041
      <211> 155
      <212> PRT
      <213> Homo sapiens


      <400> 1041
 Met Ser Leu Gly Phe Leu Tyr Leu Ser Glu Cys Phe His Gly Ser Val
   1               5                  10                  15    
 Leu His Trp Ser Thr Glu Asp Thr Arg Ser Cys Gly Ala Gln Gly Gly
              20                  25                  30        
 Gly Pro Pro Leu Pro Pro Arg Gly Met Ala Gly Thr Val Leu Gly Val
          35                  40                  45            
 Gly Ala Gly Val Phe Ile Leu Ala Leu Ile Trp Val Ala Val Leu Leu
      50                  55                  60                
 Leu Cys Val Leu Leu Ser Arg Ala Ser Gly Ala Ala Arg Phe Ser Val
  65                  70                  75                  80
 Ile Phe Leu Phe Phe Gly Ala Val Ile Ile Thr Ser Val Leu Leu Leu
                  85                  90                  95    
 Phe Pro Arg Ala Gly Glu Phe Pro Ala Pro Glu Val Glu Val Lys Ile
             100                 105                 110        
 Val Asp Asp Phe Phe Ile Gly Arg Tyr Val Leu Leu Ala Phe Leu Ser
         115                 120                 125            
 Ala Ile Phe Leu Gly Gly Leu Phe Leu Val Leu Ile His Tyr Val Leu
     130                 135                 140                
 Glu Pro Ile Tyr Ala Lys Pro Leu His Ser Tyr
 145                 150                 155



      <210> 1042
      <211> 778
      <212> PRT
      <213> Homo sapiens


      <400> 1042
 Met Lys Pro Phe Gln Leu Asp Leu Leu Phe Val Cys Phe Phe Leu Phe
   1               5                  10                  15    
 Ser Gln Glu Leu Gly Leu Gln Lys Arg Gly Cys Cys Leu Val Leu Gly
              20                  25                  30        
 Tyr Met Ala Lys Asp Lys Phe Arg Arg Met Asn Glu Gly Gln Val Tyr
          35                  40                  45            
 Ser Phe Ser Gln Gln Pro Gln Asp Gln Val Val Val Ser Gly Gln Pro
      50                  55                  60                
 Val Thr Leu Leu Cys Ala Ile Pro Glu Tyr Asp Gly Phe Val Leu Trp
  65                  70                  75                  80
 Ile Lys Asp Gly Leu Ala Leu Gly Val Gly Arg Asp Leu Ser Ser Tyr
                  85                  90                  95    
 Pro Gln Tyr Leu Val Val Gly Asn His Leu Ser Gly Glu His His Leu
             100                 105                 110        
 Lys Ile Leu Arg Ala Glu Leu Gln Asp Asp Ala Val Tyr Glu Cys Gln
         115                 120                 125            
 Ala Ile Gln Ala Ala Ile Arg Ser Arg Pro Ala Arg Leu Thr Val Leu
     130                 135                 140                
 Val Pro Pro Asp Asp Pro Val Ile Leu Gly Gly Pro Val Ile Ser Leu
 145                 150                 155                 160
 Arg Ala Gly Asp Pro Leu Asn Leu Thr Cys His Ala Asp Asn Ala Lys
                 165                 170                 175    
 Pro Ala Ala Ser Ile Ile Trp Leu Arg Lys Gly Glu Val Ile Asn Gly
             180                 185                 190        
 Ala Thr Tyr Ser Lys Thr Leu Leu Arg Asp Gly Lys Arg Glu Ser Ile
         195                 200                 205            
 Val Ser Thr Leu Phe Ile Ser Pro Gly Asp Val Glu Asn Gly Gln Ser
     210                 215                 220                
 Ile Val Cys Arg Ala Thr Asn Lys Ala Ile Pro Gly Gly Lys Glu Thr
 225                 230                 235                 240
 Ser Val Thr Ile Asp Ile Gln His Pro Pro Leu Val Asn Leu Ser Val
                 245                 250                 255    
 Glu Pro Gln Pro Val Leu Glu Asp Asn Val Val Thr Phe His Cys Ser
             260                 265                 270        
 Ala Lys Ala Asn Pro Ala Val Thr Gln Tyr Arg Trp Ala Lys Arg Gly
         275                 280                 285            
 Gln Ile Ile Lys Glu Ala Ser Gly Glu Val Tyr Arg Thr Thr Val Asp
     290                 295                 300                
 Tyr Thr Tyr Phe Ser Glu Pro Val Ser Cys Glu Val Thr Asn Ala Leu
 305                 310                 315                 320
 Gly Ser Thr Asn Leu Ser Arg Thr Val Asp Val Tyr Phe Gly Pro Arg
                 325                 330                 335    
 Met Thr Thr Glu Pro Gln Ser Leu Leu Val Asp Leu Gly Ser Asp Ala
             340                 345                 350        
 Ile Phe Ser Cys Ala Trp Thr Gly Asn Pro Ser Leu Thr Ile Val Trp
         355                 360                 365            
 Met Lys Arg Gly Ser Gly Val Val Leu Ser Asn Glu Lys Thr Leu Thr
     370                 375                 380                
 Leu Lys Ser Val Arg Gln Glu Asp Ala Gly Lys Tyr Val Cys Arg Ala
 385                 390                 395                 400
 Val Val Pro Arg Val Gly Ala Gly Glu Arg Glu Val Thr Leu Thr Val
                 405                 410                 415    
 Asn Gly Pro Pro Ile Ile Ser Ser Thr Gln Thr Gln His Ala Leu His
             420                 425                 430        
 Gly Glu Lys Gly Gln Ile Lys Cys Phe Ile Arg Ser Thr Pro Pro Pro
         435                 440                 445            
 Asp Arg Ile Ala Trp Ser Trp Lys Glu Asn Val Leu Glu Ser Gly Thr
     450                 455                 460                
 Ser Gly Arg Tyr Thr Val Glu Thr Ile Ser Thr Glu Glu Gly Val Ile
 465                 470                 475                 480
 Ser Thr Leu Thr Ile Ser Asn Ile Val Arg Ala Asp Phe Gln Thr Ile
                 485                 490                 495    
 Tyr Asn Cys Thr Ala Trp Asn Ser Phe Gly Ser Asp Thr Glu Ile Ile
             500                 505                 510        
 Arg Leu Lys Glu Gln Gly Ser Glu Met Lys Ser Gly Ala Gly Leu Glu
         515                 520                 525            
 Ala Glu Ser Val Pro Met Ala Val Ile Ile Gly Val Ala Val Gly Ala
     530                 535                 540                
 Gly Val Ala Phe Leu Val Leu Met Ala Thr Ile Val Ala Phe Cys Cys
 545                 550                 555                 560
 Ala Arg Ser Gln Arg Asn Leu Lys Gly Val Val Ser Ala Lys Asn Asp
                 565                 570                 575    
 Ile Arg Val Glu Ile Val His Lys Glu Pro Ala Ser Gly Arg Glu Gly
             580                 585                 590        
 Glu Glu His Ser Thr Ile Lys Gln Leu Met Met Asp Arg Gly Glu Phe
         595                 600                 605            
 Gln Gln Asp Ser Val Leu Lys Gln Leu Glu Val Leu Lys Glu Glu Glu
     610                 615                 620                
 Lys Glu Phe Gln Asn Leu Lys Asp Pro Thr Asn Gly Tyr Tyr Ser Val
 625                 630                 635                 640
 Asn Thr Phe Lys Glu His His Ser Thr Pro Thr Ile Ser Leu Ser Ser
                 645                 650                 655    
 Cys Gln Pro Asp Leu Arg Pro Ala Gly Lys Gln Arg Val Pro Thr Gly
             660                 665                 670        
 Met Ser Phe Thr Asn Ile Tyr Ser Thr Leu Ser Gly Gln Gly Arg Leu
         675                 680                 685            
 Tyr Asp Tyr Gly Gln Arg Phe Val Leu Gly Met Gly Ser Ser Ser Ile
     690                 695                 700                
 Glu Leu Cys Glu Arg Glu Phe Gln Arg Gly Ser Leu Ser Asp Ser Ser
 705                 710                 715                 720
 Ser Phe Leu Asp Thr Gln Cys Asp Ser Ser Val Ser Ser Ser Gly Lys
                 725                 730                 735    
 Gln Asp Gly Tyr Val Gln Phe Asp Lys Ala Ser Lys Ala Ser Ala Ser
             740                 745                 750        
 Ser Ser His His Ser Gln Ser Ser Ser Gln Asn Ser Asp Pro Ser Arg
         755                 760                 765            
 Pro Leu Gln Arg Arg Met Gln Thr His Val
     770                 775            



      <210> 1043
      <211> 190
      <212> PRT
      <213> Homo sapiens


      <400> 1043
 Met Val Leu Trp Val Arg Ala Gly Ala Trp Pro Arg Asp Ser Val Cys
   1               5                  10                  15    
 Leu Asp Ser Pro Cys Lys Cys Ser Ser Gln Lys Pro Ser Trp Pro Ser
              20                  25                  30        
 Ser Pro Trp Phe Leu Arg Gln Pro Ala Val Ile Cys Ser Phe Leu Thr
          35                  40                  45            
 Phe Leu Pro Val Pro Ser Phe Gln Val Leu Trp Thr Ile Thr Met Gly
      50                  55                  60                
 Ile Gln Gly Gly Ser Val Leu Phe Gly Leu Leu Leu Val Leu Ala Val
  65                  70                  75                  80
 Phe Cys His Ser Gly His Ser Leu Gln Cys Tyr Asn Cys Pro Asn Pro
                  85                  90                  95    
 Thr Ala Asp Cys Lys Thr Ala Val Asn Cys Ser Ser Asp Phe Asp Ala
             100                 105                 110        
 Cys Leu Ile Thr Lys Ala Gly Leu Gln Val Tyr Asn Lys Cys Trp Lys
         115                 120                 125            
 Phe Glu His Cys Asn Phe Asn Asp Val Thr Thr Arg Leu Arg Glu Asn
     130                 135                 140                
 Glu Leu Thr Tyr Tyr Cys Cys Lys Lys Asp Leu Cys Asn Phe Asn Glu
 145                 150                 155                 160
 Gln Leu Glu Asn Gly Gly Thr Ser Leu Ser Glu Lys Thr Val Leu Leu
                 165                 170                 175    
 Leu Val Thr Pro Phe Leu Ala Ala Ala Trp Ser Leu His Pro
             180                 185                 190



      <210> 1044
      <211> 518
      <212> PRT
      <213> Homo sapiens


      <400> 1044
 Met Leu Cys Ala Ser Phe Leu Gly Leu Gly Leu Ser Val Ala Ile Val
   1               5                  10                  15    
 Gly Pro Thr Phe Gln Asp Leu Ala Thr Asn Val Asn Arg Asn Ile Ser
              20                  25                  30        
 Ser Leu Ser Phe Ile Phe Val Gly Arg Ala Leu Gly Tyr Leu Ser Gly
          35                  40                  45            
 Ser Val Ile Gly Gly Phe Leu Val Asp Val Met Asn Tyr Phe Leu Leu
      50                  55                  60                
 Leu Gly Ile Ser Met Ser Ala Thr Thr Val Gly Leu Tyr Leu Val Pro
  65                  70                  75                  80
 Phe Cys Lys Thr Ala Ile Leu Leu Thr Val Met Met Ser Ile Phe Gly
                  85                  90                  95    
 Val Ser Ile Gly Ile Leu Asp Thr Gly Gly Asn Val Leu Ile Leu Ala
             100                 105                 110        
 Ile Trp Gly Asp Lys Gly Ala Pro His Met Gln Ala Leu His Phe Ser
         115                 120                 125            
 Phe Ala Leu Gly Ala Phe Leu Ala Pro Leu Leu Ala Lys Leu Ala Leu
     130                 135                 140                
 Gly Pro Thr Ala Ser Ala Glu Asn His Thr Glu Ser Asp Phe His Pro
 145                 150                 155                 160
 Ala Leu Asn Gln Ser Ser Asp Ala Asp Ser Glu Ala Leu Phe Gly Val
                 165                 170                 175    
 Pro Asn Asp Lys Asn Leu Leu Trp Ala Tyr Ala Val Ile Gly Thr Tyr
             180                 185                 190        
 Met Phe Leu Val Ser Val Ile Phe Phe Cys Leu Phe Leu Lys Asn Ser
         195                 200                 205            
 Ser Lys Gln Glu Lys Ala Arg Ala Ser Ala Glu Thr Phe Arg Arg Ala
     210                 215                 220                
 Lys Tyr His Asn Ala Leu Leu Cys Leu Leu Phe Leu Phe Phe Phe Phe
 225                 230                 235                 240
 Tyr Val Gly Ala Glu Val Thr Tyr Gly Ser Tyr Val Phe Ser Phe Ala
                 245                 250                 255    
 Thr Thr His Ala Gly Met Lys Glu Ser Glu Ala Ala Gly Leu Asn Ser
             260                 265                 270        
 Ile Phe Trp Gly Thr Phe Ala Ala Cys Arg Gly Leu Ala Ile Phe Phe
         275                 280                 285            
 Ala Thr Cys Leu Gln Pro Gly Thr Met Ile Val Leu Ser Asn Ile Gly
     290                 295                 300                
 Ser Leu Thr Ser Ser Leu Phe Leu Val Leu Phe Asp Lys Asn Pro Ile
 305                 310                 315                 320
 Cys Leu Trp Ile Ala Thr Ser Val Tyr Gly Ala Ser Met Ala Thr Thr
                 325                 330                 335    
 Phe Pro Ser Gly Val Ser Trp Ile Glu Gln Tyr Thr Thr Ile His Gly
             340                 345                 350        
 Lys Ser Ala Ala Phe Phe Val Ile Gly Ala Ser Leu Gly Glu Met Ala
         355                 360                 365            
 Ile Pro Ala Val Ile Gly Ile Leu Gln Gly Lys Tyr Pro Asp Leu Pro
     370                 375                 380                
 Val Val Leu Tyr Thr Ser Leu Gly Ala Ser Ile Ala Thr Gly Ile Leu
 385                 390                 395                 400
 Phe Pro Val Leu Tyr Lys Leu Ala Thr Ser Pro Leu Asp Arg Gln Arg
                 405                 410                 415    
 Lys Glu Asp Arg Lys Ser Glu Asp Gln Lys Ala Leu Leu Ser Ser Ser
             420                 425                 430        
 Gly Leu Asn Glu Tyr Glu Glu Glu Asn Glu Glu Glu Asp Ala Glu Lys
         435                 440                 445            
 Trp Asn Glu Met Asp Phe Glu Met Ile Glu Thr Asn Asp Thr Met Arg
     450                 455                 460                
 His Ser Ile Ile Glu Thr Ser Arg Ser Ser Leu Thr Glu Pro Thr Ala
 465                 470                 475                 480
 Glu Val Tyr Asn Gln Tyr Pro Ser Asn Ala Leu Val Phe Glu Ser Ser
                 485                 490                 495    
 Pro Phe Asn Thr Gly Ser Ala His Val Lys His Leu Pro Glu Thr Arg
             500                 505                 510        
 Thr Lys Gly Thr Asn Val
         515            



      <210> 1045
      <211> 715
      <212> PRT
      <213> Homo sapiens


      <400> 1045
 Met Asp Trp Ile Ser Phe Ser Thr Met Ala Ser Leu Ser Gly Ser Cys
   1               5                  10                  15    
 Trp Val Arg Cys Leu Gly Leu Cys Asp Arg Gly Ser Gln Trp Ser Pro
              20                  25                  30        
 Gly Met Ser Gly Met Ser Lys Ser Val Leu Arg Thr His Pro Gly Pro
          35                  40                  45            
 Gln Ser Leu Pro Arg Val Pro Gly Val Pro Cys Gly Gly Leu Leu Glu
      50                  55                  60                
 Pro Leu Ser Arg Ala Glu Val Ser Pro Arg Leu Gly Leu Arg Arg Asp
  65                  70                  75                  80
 Leu Leu Gly Gly Met Ala Pro Pro Gly Ser Ser Thr Val Phe Leu Leu
                  85                  90                  95    
 Ala Leu Thr Ile Ile Ala Ser Thr Trp Ala Leu Thr Pro Thr His Tyr
             100                 105                 110        
 Leu Thr Lys His Asp Val Glu Arg Leu Lys Ala Ser Leu Asp Arg Pro
         115                 120                 125            
 Phe Thr Asn Leu Glu Ser Ala Phe Tyr Ser Ile Val Gly Leu Ser Ser
     130                 135                 140                
 Leu Gly Ala Gln Val Pro Asp Ala Lys Lys Ala Cys Thr Tyr Ile Arg
 145                 150                 155                 160
 Ser Asn Leu Asp Pro Ser Asn Val Asp Ser Leu Phe Tyr Ala Ala Gln
                 165                 170                 175    
 Ala Ser Gln Ala Leu Ser Gly Cys Glu Ile Ser Ile Ser Asn Glu Thr
             180                 185                 190        
 Lys Asp Leu Leu Leu Ala Ala Val Ser Glu Asp Ser Ser Val Thr Gln
         195                 200                 205            
 Ile Tyr His Ala Val Ala Ala Leu Ser Gly Phe Gly Leu Pro Leu Ala
     210                 215                 220                
 Ser Gln Glu Ala Leu Ser Ala Leu Thr Ala Arg Leu Ser Lys Glu Glu
 225                 230                 235                 240
 Thr Val Leu Ala Thr Val Gln Ala Leu Gln Thr Ala Ser His Leu Ser
                 245                 250                 255    
 Gln Gln Ala Asp Leu Arg Ser Ile Val Glu Glu Ile Glu Asp Leu Val
             260                 265                 270        
 Ala Arg Leu Asp Glu Leu Gly Gly Val Tyr Leu Gln Phe Glu Glu Gly
         275                 280                 285            
 Leu Glu Thr Thr Ala Leu Phe Val Ala Ala Thr Tyr Lys Leu Met Asp
     290                 295                 300                
 His Val Gly Thr Glu Pro Ser Ile Lys Glu Asp Gln Val Ile Gln Leu
 305                 310                 315                 320
 Met Asn Ala Ile Phe Ser Lys Lys Asn Phe Glu Ser Leu Ser Glu Ala
                 325                 330                 335    
 Phe Ser Val Ala Ser Ala Ala Ala Val Leu Ser His Asn Arg Tyr His
             340                 345                 350        
 Val Pro Val Val Val Val Pro Glu Gly Ser Ala Ser Asp Thr His Glu
         355                 360                 365            
 Gln Ala Ile Leu Arg Leu Gln Val Thr Asn Val Leu Ser Gln Pro Leu
     370                 375                 380                
 Thr Gln Ala Thr Val Lys Leu Glu His Ala Lys Ser Val Ala Ser Arg
 385                 390                 395                 400
 Ala Thr Val Leu Gln Lys Thr Ser Phe Thr Pro Val Gly Asp Val Phe
                 405                 410                 415    
 Glu Leu Asn Phe Met Asn Val Lys Phe Ser Ser Gly Tyr Tyr Asp Phe
             420                 425                 430        
 Leu Val Glu Val Glu Gly Asp Asn Arg Tyr Ile Ala Asn Thr Val Glu
         435                 440                 445            
 Leu Arg Val Lys Ile Ser Thr Glu Val Gly Ile Thr Asn Val Asp Leu
     450                 455                 460                
 Ser Thr Val Asp Lys Asp Gln Ser Ile Ala Pro Lys Thr Thr Arg Val
 465                 470                 475                 480
 Thr Tyr Pro Ala Lys Ala Lys Gly Thr Phe Ile Ala Asp Ser His Gln
                 485                 490                 495    
 Asn Phe Ala Leu Phe Phe Gln Leu Val Asp Val Asn Thr Gly Ala Glu
             500                 505                 510        
 Leu Thr Pro His Gln Thr Phe Val Arg Leu His Asn Gln Lys Thr Gly
         515                 520                 525            
 Gln Glu Val Val Phe Val Ala Glu Pro Asp Asn Lys Asn Val Tyr Lys
     530                 535                 540                
 Phe Glu Leu Asp Thr Ser Glu Arg Lys Ile Glu Phe Asp Ser Ala Ser
 545                 550                 555                 560
 Gly Thr Tyr Thr Leu Tyr Leu Ile Ile Gly Asp Ala Thr Leu Lys Asn
                 565                 570                 575    
 Pro Ile Leu Trp Asn Val Ala Asp Val Val Ile Lys Phe Pro Glu Glu
             580                 585                 590        
 Glu Ala Pro Ser Thr Val Leu Ser Gln Asn Leu Phe Thr Pro Lys Gln
         595                 600                 605            
 Glu Ile Gln His Leu Phe Arg Glu Pro Glu Lys Arg Pro Pro Thr Val
     610                 615                 620                
 Val Ser Asn Thr Phe Thr Ala Leu Ile Leu Ser Pro Leu Leu Leu Leu
 625                 630                 635                 640
 Phe Ala Leu Trp Ile Arg Ile Gly Ala Asn Val Ser Asn Phe Thr Phe
                 645                 650                 655    
 Ala Pro Ser Thr Ile Ile Phe His Leu Gly His Ala Ala Met Leu Gly
             660                 665                 670        
 Leu Met Tyr Val Tyr Trp Thr Gln Leu Asn Met Phe Gln Thr Leu Lys
         675                 680                 685            
 Tyr Leu Ala Ile Leu Gly Ser Val Thr Phe Leu Ala Gly Asn Arg Met
     690                 695                 700                
 Leu Ala Gln Gln Ala Val Lys Arg Thr Ala His
 705                 710                 715



      <210> 1046
      <211> 175
      <212> PRT
      <213> Homo sapiens


      <400> 1046
 Met Gly Lys Ala Ala Ala Ala Val Ala Phe Gly Ala Glu Val Gly Val
   1               5                  10                  15    
 Arg Leu Ala Leu Phe Ala Ala Phe Leu Val Thr Glu Leu Leu Pro Pro
              20                  25                  30        
 Phe Gln Arg Leu Ile Gln Pro Glu Glu Met Trp Leu Tyr Arg Asn Pro
          35                  40                  45            
 Tyr Val Glu Ala Glu Tyr Phe Pro Thr Lys Pro Met Phe Val Ile Ala
      50                  55                  60                
 Phe Leu Ser Pro Leu Ser Leu Ile Phe Leu Ala Lys Phe Leu Lys Lys
  65                  70                  75                  80
 Ala Asp Thr Arg Asp Ser Arg Gln Ala Cys Leu Ala Ala Ser Leu Ala
                  85                  90                  95    
 Leu Ala Leu Asn Gly Val Phe Thr Asn Thr Ile Lys Leu Ile Val Gly
             100                 105                 110        
 Arg Pro Arg Pro Asp Phe Phe Tyr Arg Cys Phe Pro Asp Gly Leu Ala
         115                 120                 125            
 His Ser Asp Leu Met Cys Thr Gly Asp Lys Asp Val Val Asn Glu Gly
     130                 135                 140                
 Arg Lys Ser Phe Pro Ser Gly His Ser Ser Cys Met Asn Ile His Met
 145                 150                 155                 160
 Gly Ser Thr Leu Cys Phe Gly Phe Thr Ser Val Ser Leu Ala Leu
                 165                 170                 175



      <210> 1047
      <211> 365
      <212> PRT
      <213> Homo sapiens


      <400> 1047
 Met Ala Val Met Ala Pro Arg Thr Leu Leu Leu Leu Leu Ser Gly Ala
   1               5                  10                  15    
 Leu Ala Leu Thr Glu Thr Trp Ala Gly Ser His Ser Met Arg Tyr Phe
              20                  25                  30        
 Tyr Thr Ser Val Ser Arg Pro Gly Arg Gly Glu Pro Arg Phe Ile Ala
          35                  40                  45            
 Val Gly Tyr Val Asp Asp Thr Gln Phe Val Arg Phe Asp Ser Asp Ala
      50                  55                  60                
 Ala Ser Gln Arg Met Glu Pro Arg Ala Pro Trp Ile Glu Gln Glu Gly
  65                  70                  75                  80
 Pro Glu Tyr Trp Asp Gln Glu Thr Arg Asn Val Lys Ala His Ser Gln
                  85                  90                  95    
 Thr Asp Arg Val Asp Leu Gly Thr Leu Arg Gly Tyr Tyr Asn Gln Ser
             100                 105                 110        
 Glu Ala Gly Ser His Thr Ile Gln Arg Met Tyr Gly Cys Asp Val Gly
         115                 120                 125            
 Ser Asp Gly Arg Phe Leu Arg Gly Tyr His Gln Tyr Ala Tyr Asp Gly
     130                 135                 140                
 Lys Asp Tyr Ile Ala Leu Asn Glu Asp Leu Arg Ser Trp Thr Ala Ala
 145                 150                 155                 160
 Asp Met Ala Ala Gln Ile Thr Lys Arg Lys Trp Glu Ala Ala His Val
                 165                 170                 175    
 Ala Glu Gln Leu Arg Ala Tyr Leu Glu Gly Thr Cys Val Glu Trp Leu
             180                 185                 190        
 Arg Arg Tyr Leu Glu Asn Gly Lys Glu Thr Leu Gln Arg Thr Asp Pro
         195                 200                 205            
 Pro Lys Thr His Met Thr His His Pro Ile Ser Asn Tyr Glu Ala Thr
     210                 215                 220                
 Leu Arg Cys Trp Ala Leu Gly Phe Tyr Pro Leu Glu Ile Thr Leu Thr
 225                 230                 235                 240
 Gln Glu Arg Asp Gly Glu Asp Gln Ile Gln Asp Ala Glu Phe Val Glu
                 245                 250                 255    
 Thr Arg Leu Ala Gly Tyr Arg Thr Phe Gln Lys Trp Ala Ala Ala Val
             260                 265                 270        
 Val Ser Ser Gly Glu Lys Gln Arg Tyr Thr Cys His Val Gln His Glu
         275                 280                 285            
 Gly Leu Pro Glu Pro Leu Thr Leu Arg Trp Glu Leu Ser Ser Gln Pro
     290                 295                 300                
 Thr Ile Pro Ile Val Gly Ile Ile Ala Gly Leu Val Leu Phe Gly Ala
 305                 310                 315                 320
 Val Ile Thr Gly Ala Val Val Ala Ala Val Met Trp Arg Arg Lys Ser
                 325                 330                 335    
 Ser Asp Arg Lys Gly Gly Ser Tyr Ser Gln Ala Ala Ser Ser Asp Ser
             340                 345                 350        
 Ala Gln Gly Ser Asp Val Ser Leu Thr Ala Cys Lys Val
         355                 360                 365



      <210> 1048
      <211> 144
      <212> PRT
      <213> Homo sapiens


      <400> 1048
 Met Leu Asn Arg Ile Ile Trp Leu Gln Ala Val Leu Glu Ile Ile Thr
   1               5                  10                  15    
 Asn Lys Thr Thr Gln Ala Leu Thr Val Leu Ala Trp Gln Glu Thr Met
              20                  25                  30        
 Met Arg Asn Ala Ile Tyr Gln Asn Arg Leu Ala Leu Asp Tyr Leu Leu
          35                  40                  45            
 Ala Ala Glu Gly Gly Val Cys Glu Lys Phe Asp Leu Thr Asn Tyr Cys
      50                  55                  60                
 Leu His Ile Asp Asp Gln Gly Gln Val Val Glu Asp Ile Val Lys Asp
  65                  70                  75                  80
 Ile Thr Lys Leu Ala His Ala Pro Val Gln Val Trp His Gly Leu Asn
                  85                  90                  95    
 Leu Gly Ala Met Phe Gly Asn Trp Phe Pro Ala Ile Gly Gly Phe Lys
             100                 105                 110        
 Thr Leu Ile Ile Arg Val Ile Ile Val Ile Gly Thr Cys Leu Leu Leu
         115                 120                 125            
 Pro Cys Leu Ile Pro Val Phe Leu Gln Met Ile Lys Asn Phe Val Ala
     130                 135                 140                





      <210> 1049
      <211> 292
      <212> PRT
      <213> Homo sapiens


      <400> 1049
 Met Glu Arg Gly Pro Val Val Gly Ala Gly Leu Gly Ala Gly Ala Arg
   1               5                  10                  15    
 Ile Gln Ala Leu Leu Gly Cys Leu Leu Lys Val Leu Leu Trp Val Ala
              20                  25                  30        
 Ser Ala Leu Leu Tyr Phe Gly Ser Glu Gln Ala Ala Arg Leu Leu Gly
          35                  40                  45            
 Ser Pro Cys Leu Arg Arg Leu Tyr His Ala Trp Leu Ala Ala Val Val
      50                  55                  60                
 Ile Phe Gly Pro Leu Leu Gln Phe His Val Asn Pro Arg Thr Ile Phe
  65                  70                  75                  80
 Ala Ser His Gly Asn Phe Phe Asn Ile Lys Phe Val Asn Ser Ala Trp
                  85                  90                  95    
 Gly Trp Thr Cys Thr Phe Leu Gly Gly Phe Val Leu Leu Val Val Phe
             100                 105                 110        
 Leu Ala Thr Arg Arg Val Ala Val Thr Ala Arg His Leu Ser Arg Leu
         115                 120                 125            
 Val Val Gly Ala Ala Val Trp Arg Gly Ala Gly Arg Ala Phe Leu Leu
     130                 135                 140                
 Ile Glu Asp Leu Thr Gly Ser Cys Phe Glu Pro Leu Pro Gln Gly Leu
 145                 150                 155                 160
 Leu Leu His Glu Leu Pro Asp Arg Arg Ser Cys Leu Ala Ala Gly His
                 165                 170                 175    
 Gln Trp Arg Gly Tyr Thr Val Ser Ser His Thr Phe Leu Leu Thr Phe
             180                 185                 190        
 Cys Cys Leu Leu Met Ala Glu Glu Ala Ala Val Phe Ala Lys Tyr Leu
         195                 200                 205            
 Ala His Gly Leu Pro Ala Gly Ala Pro Leu Arg Leu Val Phe Leu Leu
     210                 215                 220                
 Asn Val Leu Leu Leu Gly Leu Trp Asn Phe Leu Leu Leu Cys Thr Val
 225                 230                 235                 240
 Ile Tyr Phe His Gln Tyr Thr His Lys Val Val Gly Ala Ala Val Gly
                 245                 250                 255    
 Thr Phe Ala Trp Tyr Leu Thr Tyr Gly Ser Trp Tyr His Gln Pro Trp
             260                 265                 270        
 Ser Pro Gly Ser Pro Gly His Gly Leu Phe Pro Arg Pro His Ser Ser
         275                 280                 285            
 Arg Lys His Asn
     290        



      <210> 1050
      <211> 249
      <212> PRT
      <213> Homo sapiens


      <400> 1050
 Met Arg Trp Cys Leu Leu Leu Ile Trp Ala Gln Gly Leu Arg Gln Ala
   1               5                  10                  15    
 Pro Leu Ala Ser Gly Met Met Thr Gly Thr Ile Glu Thr Thr Gly Asn
              20                  25                  30        
 Ile Ser Ala Glu Lys Gly Gly Ser Ile Ile Leu Gln Cys His Leu Ser
          35                  40                  45            
 Ser Thr Thr Ala Gln Val Thr Gln Val Asn Trp Glu Gln Gln Asp Gln
      50                  55                  60                
 Leu Leu Ala Ile Cys Asn Ala Asp Leu Gly Trp His Ile Ser Pro Ser
  65                  70                  75                  80
 Phe Lys Asp Arg Val Ala Pro Gly Pro Gly Leu Gly Leu Thr Leu Gln
                  85                  90                  95    
 Ser Leu Thr Val Asn Asp Thr Gly Glu Tyr Phe Cys Ile Tyr His Thr
             100                 105                 110        
 Tyr Pro Asp Gly Thr Tyr Thr Gly Arg Ile Phe Leu Glu Val Leu Glu
         115                 120                 125            
 Ser Ser Gly Ile Pro Ala Gly Ala Met Ala Glu His Gly Ala Arg Phe
     130                 135                 140                
 Gln Ile Pro Leu Leu Gly Ala Met Ala Ala Thr Leu Val Val Ile Cys
 145                 150                 155                 160
 Thr Ala Val Ile Val Val Val Ala Leu Thr Arg Lys Lys Ala Leu Arg
                 165                 170                 175    
 Ile His Ser Val Glu Gly Asp Leu Arg Arg Lys Ser Ala Gly Gln Glu
             180                 185                 190        
 Glu Trp Ser Pro Ser Ala Pro Ser Pro Pro Gly Ser Cys Val Gln Ala
         195                 200                 205            
 Glu Ala Ala Pro Ala Gly Leu Cys Gly Glu Gln Arg Gly Glu Asp Cys
     210                 215                 220                
 Ala Glu Leu His Asp Tyr Phe Asn Val Leu Ser Tyr Arg Ser Leu Gly
 225                 230                 235                 240
 Asn Cys Ser Phe Phe Thr Glu Thr Gly
                 245                



      <210> 1051
      <211> 246
      <212> PRT
      <213> Homo sapiens


      <400> 1051
 Met Ala Arg Leu Gly Ala Leu Leu Leu Ala Ala Ala Leu Gly Ala Leu
   1               5                  10                  15    
 Leu Ser Phe Ala Leu Leu Ala Ala Ala Val Ala Ser Asp Tyr Trp Tyr
              20                  25                  30        
 Ile Leu Glu Val Ala Asp Ala Gly Asn Gly Ser Ala Trp Pro Gly Arg
          35                  40                  45            
 Ala Glu Leu Leu Ser Ser His Ser Gly Leu Trp Arg Ile Cys Gly Gln
      50                  55                  60                
 Asn Gly Cys Ile Pro Leu Val Asp Pro Phe Ala Ser Glu Ser Leu Asp
  65                  70                  75                  80
 Val Ser Thr Ser Val Gln His Leu Ile Leu Leu His Arg Ala Val Ile
                  85                  90                  95    
 Val Val Leu Pro Leu Ser Leu Val Leu Leu Val Cys Gly Trp Ile Cys
             100                 105                 110        
 Gly Leu Leu Ser Ser Leu Ala Gln Ser Val Ser Leu Leu Leu Phe Thr
         115                 120                 125            
 Gly Cys Tyr Phe Leu Leu Gly Ser Val Leu Thr Leu Ala Gly Val Ser
     130                 135                 140                
 Ile Tyr Ile Ser Tyr Ser His Leu Ala Phe Ala Glu Thr Val Gln Gln
 145                 150                 155                 160
 Tyr Gly Pro Gln His Met Gln Gly Val Arg Val Ser Phe Gly Trp Ser
                 165                 170                 175    
 Met Ala Leu Ala Trp Gly Ser Cys Ala Leu Glu Ala Phe Ser Gly Thr
             180                 185                 190        
 Leu Leu Leu Ser Ala Ala Trp Thr Leu Ser Leu Ser Pro Pro Ile Cys
         195                 200                 205            
 Gly His Leu Ser Pro Gln Gln Val Gly Gly Arg Pro Trp Met Leu Lys
     210                 215                 220                
 Val Asn Thr Val His Cys Pro His Asn Gly Glu Lys Glu Glu Asn Gly
 225                 230                 235                 240
 Met Arg Asp Pro Leu Tyr
                 245    



      <210> 1052
      <211> 88
      <212> PRT
      <213> Homo sapiens


      <400> 1052
 Met Lys Ala Leu Met Leu Leu Thr Leu Ser Val Leu Leu Cys Trp Val
   1               5                  10                  15    
 Ser Gly Lys Met Trp Val Phe Ser Asn Leu Arg Cys Gly Thr Pro Glu
              20                  25                  30        
 Glu Pro Cys Gln Glu Ala Phe Asn Gln Thr Asn Arg Lys Leu Gly Leu
          35                  40                  45            
 Thr Tyr Asn Thr Thr Cys Cys Asn Lys Asp Asn Cys Asn Ser Ala Gly
      50                  55                  60                
 Pro Arg Pro Thr Pro Ala Leu Gly Leu Val Phe Leu Thr Ser Leu Ala
  65                  70                  75                  80
 Gly Leu Gly Leu Trp Leu Leu His
                  85            



      <210> 1053
      <211> 275
      <212> PRT
      <213> Homo sapiens


      <400> 1053
 Met Ala Pro Pro Pro Pro Ser Pro Gln Leu Leu Leu Leu Ala Ala Leu
   1               5                  10                  15    
 Ala Arg Leu Leu Gly Pro Ser Glu Ala Glu Asp Val Thr Phe Leu Tyr
              20                  25                  30        
 His Pro Cys Ala His Pro Trp Leu Lys Leu Gln Leu Ala Leu Leu Ala
          35                  40                  45            
 Tyr Ala Cys Met Ala Asn Pro Ser Leu Thr Pro Asp Phe Ser Leu Thr
      50                  55                  60                
 Gln Asp Arg Ala Leu Ala Leu Ala Phe Ala Leu Arg Ser Trp Arg Pro
  65                  70                  75                  80
 Pro Gly Thr Glu Val Thr Ser Gln Gly Pro Arg Gln Pro Ser Ser Ser
                  85                  90                  95    
 Gly Ala Lys Arg Arg Arg Leu Arg Ala Ala Leu Gly Pro Gln Pro Thr
             100                 105                 110        
 Arg Ser Ala Leu Arg Phe Pro Ser Ala Ser Pro Gly Ser Leu Lys Ala
         115                 120                 125            
 Lys Gln Ser Met Ala Gly Ile Pro Gly Arg Glu Ser Asn Ala Pro Ser
     130                 135                 140                
 Val Pro Thr Val Ser Leu Leu Pro Gly Ala Pro Gly Gly Asn Ala Ser
 145                 150                 155                 160
 Ser Arg Thr Glu Ala Gln Val Pro Asn Gly Gln Gly Ser Pro Gly Gly
                 165                 170                 175    
 Cys Val Cys Ser Ser Gln Ala Ser Pro Ala Pro Arg Ala Ala Ala Pro
             180                 185                 190        
 Pro Arg Ala Ala Arg Gly Pro Thr Pro Arg Thr Glu Glu Ala Ala Trp
         195                 200                 205            
 Ala Ala Met Ala Leu Thr Phe Leu Leu Val Leu Leu Thr Leu Ala Thr
     210                 215                 220                
 Leu Cys Thr Arg Leu His Arg Asn Phe Arg Arg Gly Glu Ser Ile Tyr
 225                 230                 235                 240
 Trp Gly Pro Arg Pro Leu Pro Arg Gly Pro Arg Ala Gly Arg Ser Leu
                 245                 250                 255    
 Val Ala Met Ala Arg His Trp Pro Ser Thr Ala Gly Ala Phe Leu Leu
             260                 265                 270        
 Val Gly Cys
         275



      <210> 1054
      <211> 826
      <212> PRT
      <213> Homo sapiens


      <400> 1054
 Met Ala Arg Ala Arg Ala Gly Ala Leu Leu Ala Leu Trp Val Leu Gly
   1               5                  10                  15    
 Ala Ala Ala His Pro Gln Cys Leu Asp Phe Arg Pro Pro Phe Arg Pro
              20                  25                  30        
 Thr Gln Pro Leu Arg Leu Cys Ala Gln Tyr Ser Asp Phe Gly Cys Cys
          35                  40                  45            
 Asp Glu Gly Arg Asp Ala Glu Leu Thr Arg Arg Phe Trp Ala Leu Ala
      50                  55                  60                
 Ser Arg Val Asp Ala Ala Glu Trp Ala Ala Cys Ala Gly Tyr Ala Arg
  65                  70                  75                  80
 Asp Leu Leu Cys Gln Ser Val Glu Trp Thr Asp Met Gln Arg Asp Asn
                  85                  90                  95    
 Glu Val Leu Ala Lys Leu Thr Gly Trp Ser Ala Pro Gly Asp Gly Ala
             100                 105                 110        
 Val Thr Ala Val Glu Asn Ser Pro Ser Leu Asp Tyr Pro Gly Leu Gly
         115                 120                 125            
 Thr Thr Phe Thr Ser Cys Glu Cys Ser Pro Tyr Ala Ala His Leu Tyr
     130                 135                 140                
 Asp Ala Glu Asp Pro Phe Thr Pro Leu Arg Thr Val Pro Gly Leu Cys
 145                 150                 155                 160
 Gln Asp Tyr Cys Leu Asp Met Trp His Lys Cys Arg Gly Leu Phe Arg
                 165                 170                 175    
 His Leu Ser Thr Asp Gln Glu Leu Trp Ala Leu Glu Gly Asn Leu Ala
             180                 185                 190        
 Arg Phe Cys Arg Tyr Leu Ser Leu Asp Asp Thr Asp Tyr Cys Phe Pro
         195                 200                 205            
 Tyr Leu Leu Val Asn Lys Asn Leu Asn Ser Asn Leu Gly His Val Val
     210                 215                 220                
 Ala Asp Ala Lys Gly Cys Leu Gln Leu Cys Leu Glu Glu Val Ala Asn
 225                 230                 235                 240
 Gly Leu Arg Asn Pro Val Ala Met Val His Ala Arg Asp Gly Thr His
                 245                 250                 255    
 Arg Phe Phe Val Ala Glu Gln Val Gly Leu Val Trp Ala Tyr Leu Pro
             260                 265                 270        
 Asp Arg Ser Arg Leu Gly Lys Pro Phe Leu Asn Ile Ser Arg Val Val
         275                 280                 285            
 Leu Thr Ser Pro Trp Glu Gly Asp Glu Arg Gly Phe Leu Gly Ile Ala
     290                 295                 300                
 Phe His Pro Ser Phe Gln His Asn Arg Arg Leu Tyr Val Tyr Tyr Ser
 305                 310                 315                 320
 Val Gly Ile Arg Ser Ser Glu Trp Ile Arg Ile Ser Glu Phe Arg Val
                 325                 330                 335    
 Ser Glu Asp Asp Glu Asn Ala Val Asp His Ser Ser Glu Arg Ile Ile
             340                 345                 350        
 Leu Glu Val Lys Glu Pro Ala Ser Asn His Asn Gly Gly Gln Leu Leu
         355                 360                 365            
 Phe Gly Asp Asp Gly Tyr Leu Tyr Ile Phe Thr Gly Asp Gly Gly Met
     370                 375                 380                
 Ala Gly Asp Pro Phe Gly Thr Phe Gly Asn Ala Gln Asn Lys Tyr Val
 385                 390                 395                 400
 Gln Leu Leu Ile Gly Leu Trp Val Gly Leu His Ile Pro Gly Leu Leu
                 405                 410                 415    
 Ile Leu Phe Gln Arg Ser Ala Leu Leu Gly Lys Val Leu Arg Ile Asp
             420                 425                 430        
 Val Asp Arg Lys Gly Ala Arg Pro Ala Leu Arg His Pro Ala Arg Gln
         435                 440                 445            
 Pro Val Arg Gly Arg Pro Arg Gly Ala Ala Glu Val Tyr Ala Leu Gly
     450                 455                 460                
 Val Arg Asn Met Trp Arg Cys Ser Phe Asp Arg Gly Asp Pro Ser Ser
 465                 470                 475                 480
 Gly Thr Gly Arg Gly Arg Leu Phe Cys Gly Asp Val Gly Gln Asn Lys
                 485                 490                 495    
 Phe Glu Glu Val Asp Val Val Glu Arg Gly Gly Asn Tyr Gly Trp Arg
             500                 505                 510        
 Ala Arg Glu Gly Phe Glu Cys Tyr Asp Arg Ser Leu Cys Ala Asn Thr
         515                 520                 525            
 Ser Leu Asn Asp Leu Leu Pro Ile Phe Ala Tyr Pro His Thr Val Gly
     530                 535                 540                
 Lys Ser Val Thr Gly Gly Tyr Val Tyr Arg Gly Cys Glu Tyr Pro Asn
 545                 550                 555                 560
 Leu Asn Gly Leu Tyr Ile Phe Gly Asp Phe Met Ser Gly Arg Leu Met
                 565                 570                 575    
 Ser Leu Gln Glu Asn Pro Gly Thr Gly Gln Trp Gln Tyr Ser Glu Ile
             580                 585                 590        
 Cys Met Gly His Gly Gln Thr Cys Glu Phe Pro Gly Leu Ile Asn Asn
         595                 600                 605            
 Tyr Tyr Pro Tyr Ile Ile Ser Phe Gly Glu Asp Glu Ala Gly Glu Leu
     610                 615                 620                
 Tyr Phe Met Ser Thr Gly Glu Pro Ser Ala Thr Ala Pro Arg Gly Val
 625                 630                 635                 640
 Val Tyr Lys Ile Ile Asp Ala Ser Arg Val His Pro Glu Asp Thr Glu
                 645                 650                 655    
 His Pro Ala Ala Tyr Ser Ala Gly Ala His Ala Gly Ala Arg Arg Gly
             660                 665                 670        
 Arg Pro Thr Ala Ala Pro Pro Ala Pro Thr Pro Arg Pro Ala Arg Pro
         675                 680                 685            
 Thr Gln Gln Pro Gly Ser Arg Arg Gly Gly Gly Arg Arg Arg Gly Arg
     690                 695                 700                
 Leu Asn Ser Ala Ser Arg Ala Phe Arg Asp Gly Glu Val Arg Leu Val
 705                 710                 715                 720
 Arg Pro Ala Gly Leu Ser Ser Gly Ser Gly Arg Val Glu Val Phe Val
                 725                 730                 735    
 Gly Gly Arg Trp Gly Thr Val Cys Asp Asp Ser Trp Asn Ile Ser Gly
             740                 745                 750        
 Ala Ala Val Val Cys Arg Gln Leu Gly Phe Ala Tyr Ala Val Arg Ala
         755                 760                 765            
 Val Lys Arg Ala Glu Phe Gly Gln Gly Gly Ser Leu Pro Ile Leu Leu
     770                 775                 780                
 Asp Asp Val Arg Cys Ala Gly Trp Glu Arg Asn Leu Leu Glu Cys Gln
 785                 790                 795                 800
 His Asn Gly Val Gly Thr His Asn Cys Glu His Asp Glu Asp Ala Gly
                 805                 810                 815    
 Val Val Cys Ser His Gln Asn Pro Asp Leu
             820                 825    



      <210> 1055
      <211> 422
      <212> PRT
      <213> Homo sapiens


      <400> 1055
 Met Ala Gly Cys Cys Ala Ala Leu Ala Ala Phe Leu Phe Glu Tyr Asp
   1               5                  10                  15    
 Thr Pro Arg Ile Val Leu Ile Arg Ser Arg Lys Val Gly Leu Met Asn
              20                  25                  30        
 Arg Ala Val Gln Leu Leu Ile Leu Ala Tyr Val Ile Gly Trp Val Phe
          35                  40                  45            
 Val Trp Glu Lys Gly Tyr Gln Glu Thr Asp Ser Val Val Ser Ser Val
      50                  55                  60                
 Thr Thr Lys Val Lys Gly Val Ala Val Thr Asn Thr Ser Lys Leu Gly
  65                  70                  75                  80
 Phe Arg Ile Trp Asp Val Ala Asp Tyr Val Ile Pro Ala Gln Glu Glu
                  85                  90                  95    
 Asn Ser Leu Phe Val Met Thr Asn Val Ile Leu Thr Met Asn Gln Thr
             100                 105                 110        
 Gln Gly Leu Cys Pro Glu Ile Pro Asp Ala Thr Thr Val Cys Lys Ser
         115                 120                 125            
 Asp Ala Ser Cys Thr Ala Gly Ser Ala Gly Thr His Ser Asn Gly Val
     130                 135                 140                
 Ser Thr Gly Arg Cys Val Ala Phe Asn Gly Ser Val Lys Thr Cys Glu
 145                 150                 155                 160
 Val Ala Ala Trp Cys Pro Val Glu Asp Asp Thr His Val Pro Gln Pro
                 165                 170                 175    
 Ala Phe Leu Lys Ala Ala Glu Asn Phe Thr Leu Leu Val Lys Asn Asn
             180                 185                 190        
 Ile Trp Tyr Pro Lys Phe Asn Phe Ser Lys Arg Asn Ile Leu Pro Asn
         195                 200                 205            
 Ile Thr Thr Thr Tyr Leu Lys Ser Cys Ile Tyr Asp Ala Lys Thr Asp
     210                 215                 220                
 Pro Phe Cys Pro Ile Phe Arg Leu Gly Lys Ile Val Glu Asn Ala Gly
 225                 230                 235                 240
 His Ser Phe Gln Asp Met Ala Val Glu Gly Gly Ile Met Gly Ile Gln
                 245                 250                 255    
 Val Asn Trp Asp Cys Asn Leu Asp Arg Ala Ala Ser Leu Cys Leu Pro
             260                 265                 270        
 Arg Tyr Ser Phe Arg Arg Leu Asp Thr Arg Asp Val Glu His Asn Val
         275                 280                 285            
 Ser Pro Gly Tyr Asn Phe Arg Phe Ala Lys Tyr Tyr Arg Asp Leu Ala
     290                 295                 300                
 Gly Asn Glu Gln Arg Thr Leu Ile Lys Ala Tyr Gly Ile Arg Phe Asp
 305                 310                 315                 320
 Ile Ile Val Phe Gly Lys Ala Gly Lys Phe Asp Ile Ile Pro Thr Met
                 325                 330                 335    
 Ile Asn Ile Gly Ser Gly Leu Ala Leu Leu Gly Met Ala Thr Val Leu
             340                 345                 350        
 Cys Asp Ile Ile Val Leu Tyr Cys Met Lys Lys Arg Leu Tyr Tyr Arg
         355                 360                 365            
 Glu Lys Lys Tyr Lys Tyr Val Glu Asp Tyr Glu Gln Val Gly Pro Ser
     370                 375                 380                
 Trp Pro Pro Ala Gly Thr Gly Leu Ser Ser Leu Gly Cys Gly Ser Pro
 385                 390                 395                 400
 Gly Arg Gly Pro Val Trp Gly Gly Pro Ser Ala Glu Ala Gly Thr Ser
                 405                 410                 415    
 Val Ala Trp Cys Pro Arg
             420        



      <210> 1056
      <211> 280
      <212> PRT
      <213> Homo sapiens


      <400> 1056
 Met Gln Leu Gln Val Phe Trp Thr Gly Leu Glu Tyr Thr Cys Arg Leu
   1               5                  10                  15    
 Leu Gly Ile Thr Thr Ala Ala Val Leu Ile Gly Val Gly Thr Glu Thr
              20                  25                  30        
 Phe Leu Gln Gly Gln Phe Lys Ser Leu Ala Phe Tyr Leu Leu Met Ala
          35                  40                  45            
 Gln Ser Gly Thr Arg His Val Leu Glu Thr Ala Arg Gly Glu Cys Cys
      50                  55                  60                
 Leu Gly Glu Ser Arg Phe Thr Gly Ala Ala Val Ser Ile Cys Glu Gly
  65                  70                  75                  80
 Ala Tyr Phe Val Ala Gln Leu Leu Ala Ile Cys Phe Gln Cys Gln Pro
                  85                  90                  95    
 Gly Ser Leu Ala Asp Arg Val Arg Glu Lys Ala His Trp Leu Gly Cys
             100                 105                 110        
 Phe Gln Lys Phe Leu Ala Tyr Leu Leu Leu Ser Val Ala Cys Phe Leu
         115                 120                 125            
 His Pro Val Leu Val Trp His Val Thr Ile Pro Gly Ser Met Leu Ile
     130                 135                 140                
 Ile Thr Gly Leu Ala Tyr Phe Leu Leu Ser Lys Arg Lys Lys Arg Lys
 145                 150                 155                 160
 Ala Ala Pro Glu Val Leu Ala Ser Pro Glu Gln Tyr Thr Asp Pro Ser
                 165                 170                 175    
 Ser Ser Ala Val Ser Thr Thr Gly Ser Gly Asp Thr Glu Gln Thr Tyr
             180                 185                 190        
 Thr Phe His Gly Ala Leu Lys Glu Gly Pro Ser Ser Leu Phe Ile His
         195                 200                 205            
 Met Lys Ser Ile Leu Lys Gly Thr Lys Lys Pro Ser Ala Leu Gln Pro
     210                 215                 220                
 Pro Asn Thr Leu Met Glu Leu Ser Leu Glu Pro Ala Asp Ser Leu Ala
 225                 230                 235                 240
 Lys Lys Lys Gln Val His Phe Glu Asp Asn Leu Val Arg Ile Val Pro
                 245                 250                 255    
 Ser Leu Ala Glu Gly Leu Asp Asp Gly Asp Thr Pro Leu Phe Leu Ser
             260                 265                 270        
 Ser Leu Thr Ala Thr Gly Leu Phe
         275                 280



      <210> 1057
      <211> 627
      <212> PRT
      <213> Homo sapiens


      <400> 1057
 Met Ala Gly Gly Ser Ala Thr Thr Trp Gly Tyr Pro Val Ala Leu Leu
   1               5                  10                  15    
 Leu Leu Val Ala Thr Leu Gly Leu Gly Leu Arg His Ser Tyr Asp Cys
              20                  25                  30        
 Gly Ile Lys Gly Met Gln Leu Leu Val Phe Pro Arg Pro Gly Gln Thr
          35                  40                  45            
 Leu Arg Phe Lys Val Val Asp Glu Phe Gly Asn Arg Phe Asp Val Asn
      50                  55                  60                
 Asn Cys Ser Ile Cys Tyr His Trp Val Thr Ser Arg Pro Gln Glu Pro
  65                  70                  75                  80
 Ala Val Phe Ser Ala Asp Tyr Arg Gly Cys His Val Leu Glu Lys Asp
                  85                  90                  95    
 Gly Arg Phe His Leu Arg Val Phe Met Glu Ala Val Leu Pro Asn Gly
             100                 105                 110        
 Arg Val Asp Val Ala Gln Asp Ala Thr Leu Ile Cys Pro Lys Pro Asp
         115                 120                 125            
 Pro Ser Arg Thr Leu Asp Ser Gln Leu Ala Pro Pro Ala Met Phe Ser
     130                 135                 140                
 Val Ser Thr Pro Gln Thr Leu Ser Phe Leu Pro Thr Ser Gly His Thr
 145                 150                 155                 160
 Ser Gln Gly Ser Gly His Ala Phe Pro Ser Pro Leu Asp Pro Gly His
                 165                 170                 175    
 Ser Ser Val His Pro Thr Pro Ala Leu Pro Ser Pro Gly Pro Gly Pro
             180                 185                 190        
 Thr Leu Ala Thr Leu Ala Gln Pro His Trp Gly Thr Leu Glu His Trp
         195                 200                 205            
 Asp Val Asn Lys Arg Asp Tyr Ile Gly Thr His Leu Ser Gln Glu Gln
     210                 215                 220                
 Cys Gln Val Ala Ser Gly His Leu Pro Cys Ile Val Arg Arg Thr Ser
 225                 230                 235                 240
 Lys Glu Ala Cys Gln Gln Ala Gly Cys Cys Tyr Asp Asn Thr Arg Glu
                 245                 250                 255    
 Val Pro Cys Tyr Tyr Gly Asn Thr Ala Thr Val Gln Cys Phe Arg Asp
             260                 265                 270        
 Gly Tyr Phe Val Leu Val Val Ser Gln Glu Met Ala Leu Thr His Arg
         275                 280                 285            
 Ile Thr Leu Ala Asn Ile His Leu Ala Tyr Ala Pro Thr Ser Cys Ser
     290                 295                 300                
 Pro Thr Gln His Thr Glu Ala Phe Val Val Phe Tyr Phe Pro Leu Thr
 305                 310                 315                 320
 His Cys Gly Thr Thr Met Gln Val Ala Gly Asp Gln Leu Ile Tyr Glu
                 325                 330                 335    
 Asn Trp Leu Val Ser Gly Ile His Ile Gln Lys Gly Pro Gln Gly Ser
             340                 345                 350        
 Ile Thr Arg Asp Ser Thr Phe Gln Leu His Val Arg Cys Val Phe Asn
         355                 360                 365            
 Ala Ser Asp Phe Leu Pro Ile Gln Ala Ser Ile Phe Pro Pro Pro Ser
     370                 375                 380                
 Pro Ala Pro Met Thr Gln Pro Gly Pro Leu Arg Leu Glu Leu Arg Ile
 385                 390                 395                 400
 Ala Lys Asp Glu Thr Phe Ser Ser Tyr Tyr Gly Glu Asp Asp Tyr Pro
                 405                 410                 415    
 Ile Val Arg Leu Leu Arg Glu Pro Val His Val Glu Val Arg Leu Leu
             420                 425                 430        
 Gln Arg Thr Asp Pro Asn Leu Val Leu Leu Leu His Gln Cys Trp Gly
         435                 440                 445            
 Ala Pro Ser Ala Asn Pro Phe Gln Gln Pro Gln Trp Pro Ile Leu Ser
     450                 455                 460                
 Asp Gly Cys Pro Phe Lys Gly Asp Ser Tyr Arg Thr Gln Met Val Ala
 465                 470                 475                 480
 Leu Asp Gly Ala Thr Pro Phe Gln Ser His Tyr Gln Arg Phe Thr Val
                 485                 490                 495    
 Ala Thr Phe Ala Leu Leu Asp Ser Gly Ser Gln Arg Ala Leu Arg Gly
             500                 505                 510        
 Leu Val Tyr Leu Phe Cys Ser Thr Ser Ala Cys His Thr Ser Gly Leu
         515                 520                 525            
 Glu Thr Cys Ser Thr Ala Cys Ser Thr Gly Thr Thr Arg Gln Arg Arg
     530                 535                 540                
 Ser Ser Gly His Arg Asn Asp Thr Ala Arg Pro Gln Asp Ile Val Ser
 545                 550                 555                 560
 Ser Pro Gly Pro Val Gly Phe Glu Asp Ser Tyr Gly Gln Glu Pro Thr
                 565                 570                 575    
 Leu Gly Pro Thr Asp Ser Asn Gly Asn Ser Ser Leu Arg Pro Leu Leu
             580                 585                 590        
 Trp Ala Val Leu Leu Leu Pro Ala Val Ala Leu Val Leu Gly Phe Gly
         595                 600                 605            
 Val Phe Val Gly Leu Ser Gln Thr Trp Ala Gln Lys Leu Trp Glu Ser
     610                 615                 620                
 Asn Arg Gln
 625        



      <210> 1058
      <211> 438
      <212> PRT
      <213> Homo sapiens


      <400> 1058
 Met Thr Ala Ala Ala Ala Ser Asn Trp Gly Leu Ile Thr Asn Ile Val
   1               5                  10                  15    
 Asn Ser Ile Val Gly Val Ser Val Leu Thr Met Pro Phe Cys Phe Lys
              20                  25                  30        
 Gln Cys Gly Ile Val Leu Gly Ala Leu Leu Leu Val Phe Cys Ser Trp
          35                  40                  45            
 Met Thr His Gln Ser Cys Met Phe Leu Val Lys Ser Ala Ser Leu Ser
      50                  55                  60                
 Lys Arg Arg Thr Tyr Ala Gly Leu Ala Phe His Ala Tyr Gly Lys Ala
  65                  70                  75                  80
 Gly Lys Met Leu Val Glu Thr Ser Met Ile Gly Leu Met Leu Gly Thr
                  85                  90                  95    
 Cys Ile Ala Phe Tyr Val Val Ile Gly Asp Leu Gly Ser Asn Phe Phe
             100                 105                 110        
 Ala Arg Leu Phe Gly Phe Gln Val Gly Gly Thr Phe Arg Met Phe Leu
         115                 120                 125            
 Leu Phe Ala Val Ser Leu Cys Ile Val Leu Pro Leu Ser Leu Gln Arg
     130                 135                 140                
 Asn Met Met Ala Ser Ile Gln Ser Phe Ser Ala Met Ala Leu Leu Phe
 145                 150                 155                 160
 Tyr Thr Val Phe Met Phe Val Ile Val Leu Ser Ser Leu Lys His Gly
                 165                 170                 175    
 Leu Phe Ser Gly Gln Trp Leu Arg Arg Val Ser Tyr Val Arg Trp Glu
             180                 185                 190        
 Gly Val Phe Arg Cys Ile Pro Ile Phe Gly Met Ser Phe Ala Cys Gln
         195                 200                 205            
 Ser Gln Val Leu Pro Thr Tyr Asp Ser Leu Asp Glu Pro Ser Val Lys
     210                 215                 220                
 Thr Met Ser Ser Ile Phe Ala Ser Ser Leu Asn Val Val Thr Thr Phe
 225                 230                 235                 240
 Tyr Val Met Val Gly Phe Phe Gly Tyr Val Ser Phe Thr Glu Ala Thr
                 245                 250                 255    
 Ala Gly Asn Val Leu Met His Phe Pro Ser Asn Leu Val Thr Glu Met
             260                 265                 270        
 Leu Arg Val Gly Phe Met Met Ser Val Ala Val Gly Phe Pro Met Met
         275                 280                 285            
 Ile Leu Pro Cys Arg Gln Ala Leu Ser Thr Leu Leu Cys Glu Gln Gln
     290                 295                 300                
 Gln Lys Asp Gly Thr Phe Ala Ala Gly Gly Tyr Met Pro Pro Leu Arg
 305                 310                 315                 320
 Phe Lys Ala Leu Thr Leu Ser Val Val Phe Gly Thr Met Val Gly Gly
                 325                 330                 335    
 Ile Leu Ile Pro Asn Val Glu Thr Ile Leu Gly Leu Thr Gly Ala Thr
             340                 345                 350        
 Met Gly Ser Leu Ile Cys Phe Ile Cys Pro Gly Ala Asp Leu Gln Glu
         355                 360                 365            
 Asn Pro Gln Glu Arg Thr Phe Leu Pro Gly Gly Ala Val Gly Arg Pro
     370                 375                 380                
 Gly Arg Pro Gly Gly Glu His Cys His His Thr Val Cys Glu Arg Gly
 385                 390                 395                 400
 Gly Pro Arg Gly Leu Gly Arg Gly Ser Pro Trp Arg Pro Ala Trp Arg
                 405                 410                 415    
 Gly Arg Gly Phe Asp Glu Gly Gly Gly Ser Ala Ala Leu Ser Pro Gly
             420                 425                 430        
 Ser Gly Cys Gly Arg Gly
         435            



      <210> 1059
      <211> 424
      <212> PRT
      <213> Homo sapiens


      <400> 1059
 Met Lys Ser Pro Phe Tyr Arg Cys Gln Asn Thr Thr Ser Val Glu Lys
   1               5                  10                  15    
 Gly Asn Ser Ala Val Met Gly Gly Val Leu Phe Ser Thr Gly Leu Leu
              20                  25                  30        
 Gly Asn Leu Leu Ala Leu Gly Leu Leu Ala Arg Ser Gly Leu Gly Trp
          35                  40                  45            
 Cys Ser Arg Arg Pro Leu Arg Pro Leu Pro Ser Val Phe Tyr Met Leu
      50                  55                  60                
 Val Cys Gly Leu Thr Val Thr Asp Leu Leu Gly Lys Cys Leu Leu Ser
  65                  70                  75                  80
 Pro Val Val Leu Ala Ala Tyr Ala Gln Asn Arg Ser Leu Arg Val Leu
                  85                  90                  95    
 Ala Pro Ala Leu Asp Asn Ser Leu Cys Gln Ala Phe Ala Phe Phe Met
             100                 105                 110        
 Ser Phe Phe Gly Leu Ser Ser Thr Leu Gln Leu Leu Ala Met Ala Leu
         115                 120                 125            
 Glu Cys Trp Leu Ser Leu Gly His Pro Phe Phe Tyr Arg Arg His Ile
     130                 135                 140                
 Thr Leu Arg Leu Gly Ala Leu Val Ala Pro Val Val Ser Ala Phe Ser
 145                 150                 155                 160
 Leu Ala Phe Cys Ala Leu Pro Phe Met Gly Phe Gly Lys Phe Val Gln
                 165                 170                 175    
 Tyr Cys Pro Gly Thr Trp Cys Phe Ile Gln Met Val His Glu Glu Gly
             180                 185                 190        
 Ser Leu Ser Val Leu Gly Tyr Ser Val Leu Tyr Ser Ser Leu Met Ala
         195                 200                 205            
 Leu Leu Val Leu Ala Thr Val Leu Cys Asn Leu Gly Ala Met Arg Asn
     210                 215                 220                
 Leu Tyr Ala Met His Arg Arg Leu Gln Arg His Pro Arg Ser Cys Thr
 225                 230                 235                 240
 Arg Asp Cys Ala Glu Pro Arg Ala Asp Gly Arg Glu Ala Ser Pro Gln
                 245                 250                 255    
 Pro Leu Glu Glu Leu Asp His Leu Leu Leu Leu Ala Leu Met Thr Val
             260                 265                 270        
 Leu Phe Thr Met Cys Ser Leu Pro Val Ile Val Ser Pro Arg Ala Pro
         275                 280                 285            
 Arg Gln Gln Gly Thr Glu Thr Val Arg Pro Arg Met Arg Gly Gly Lys
     290                 295                 300                
 Gly Gly Ala Asp Arg Asp Gly Arg Gly Ala Arg Arg Ala Ala Pro Trp
 305                 310                 315                 320
 Ala Arg Lys Tyr Arg Ala Tyr Tyr Gly Ala Phe Lys Asp Val Lys Glu
                 325                 330                 335    
 Lys Asn Arg Thr Ser Glu Glu Ala Glu Asp Leu Arg Ala Leu Arg Phe
             340                 345                 350        
 Leu Ser Val Ile Ser Ile Val Asp Pro Trp Ile Phe Ile Ile Phe Arg
         355                 360                 365            
 Ser Pro Val Phe Arg Ile Phe Phe His Lys Ile Phe Ile Arg Pro Leu
     370                 375                 380                
 Ser Tyr Leu Leu Gln Pro Tyr Ser Ala Val Arg Gly His Gly Lys Ile
 385                 390                 395                 400
 Leu Gly Ser Lys Ile Leu Leu Gln Ile Thr Pro Ser Lys Leu Glu Gln
                 405                 410                 415    
 His Ile Ala Glu Lys Glu His Asn
             420                



      <210> 1060
      <211> 568
      <212> PRT
      <213> Homo sapiens


      <400> 1060
 Met Ala Ser Ala Leu Ile Tyr Val Ser Lys Phe Lys Ser Phe Val Ile
   1               5                  10                  15    
 Leu Val Gly Thr Pro Leu Leu Leu Leu Pro Leu Val Ile Leu Met Pro
              20                  25                  30        
 Ala Lys Phe Val Arg Cys Ala Tyr Val Ile Ile Leu Met Ala Ile Tyr
          35                  40                  45            
 Trp Cys Thr Glu Val Ile Pro Leu Ala Val Thr Ser Leu Met Pro Val
      50                  55                  60                
 Leu Leu Phe Pro Leu Phe Gln Ile Leu Asp Ser Arg Gln Val Cys Val
  65                  70                  75                  80
 Gln Tyr Met Lys Asp Thr Asn Met Leu Phe Leu Gly Gly Leu Ile Val
                  85                  90                  95    
 Ala Val Ala Val Glu Arg Trp Asn Leu His Lys Arg Ile Ala Leu Arg
             100                 105                 110        
 Thr Leu Leu Trp Val Gly Ala Lys Pro Ala Arg Leu Met Leu Gly Phe
         115                 120                 125            
 Met Gly Val Thr Ala Leu Leu Ser Met Trp Ile Ser Asn Thr Ala Thr
     130                 135                 140                
 Thr Ala Met Met Val Pro Ile Val Glu Ala Ile Leu Gln Gln Met Glu
 145                 150                 155                 160
 Ala Thr Ser Ala Ala Thr Glu Ala Gly Leu Glu Leu Val Asp Lys Gly
                 165                 170                 175    
 Lys Ala Lys Glu Leu Pro Gly Ser Gln Val Ile Phe Glu Gly Pro Thr
             180                 185                 190        
 Leu Gly Gln Gln Glu Asp Gln Glu Arg Lys Arg Leu Cys Lys Ala Met
         195                 200                 205            
 Thr Leu Cys Ile Cys Tyr Ala Ala Ser Ile Gly Gly Thr Ala Thr Leu
     210                 215                 220                
 Thr Gly Thr Gly Pro Asn Val Val Leu Leu Gly Gln Met Asn Glu Leu
 225                 230                 235                 240
 Phe Pro Asp Ser Lys Asp Leu Val Asn Phe Ala Ser Trp Phe Ala Phe
                 245                 250                 255    
 Ala Phe Pro Asn Met Leu Val Met Leu Leu Phe Ala Trp Leu Trp Leu
             260                 265                 270        
 Gln Phe Val Tyr Met Arg Phe Asn Phe Lys Lys Ser Trp Gly Cys Gly
         275                 280                 285            
 Leu Glu Ser Lys Lys Asn Glu Lys Ala Ala Leu Lys Val Leu Gln Glu
     290                 295                 300                
 Glu Tyr Arg Lys Leu Gly Pro Leu Ser Phe Ala Glu Ile Asn Val Leu
 305                 310                 315                 320
 Ile Cys Phe Phe Leu Leu Val Ile Leu Trp Phe Ser Arg Asp Pro Gly
                 325                 330                 335    
 Phe Met Pro Gly Trp Leu Thr Val Ala Trp Val Glu Gly Glu Thr Lys
             340                 345                 350        
 Tyr Val Ser Asp Ala Thr Val Ala Ile Phe Val Ala Thr Leu Leu Phe
         355                 360                 365            
 Ile Val Pro Ser Gln Lys Pro Lys Phe Asn Phe Arg Ser Gln Thr Glu
     370                 375                 380                
 Glu Glu Arg Lys Thr Pro Phe Tyr Pro Pro Pro Leu Leu Asp Trp Lys
 385                 390                 395                 400
 Val Thr Gln Glu Lys Val Pro Trp Gly Ile Val Leu Leu Leu Gly Gly
                 405                 410                 415    
 Gly Phe Ala Leu Ala Lys Gly Ser Glu Ala Ser Gly Leu Ser Val Trp
             420                 425                 430        
 Met Gly Lys Gln Met Glu Pro Leu His Ala Val Pro Pro Ala Ala Ile
         435                 440                 445            
 Thr Leu Ile Leu Ser Leu Leu Val Ala Val Phe Thr Glu Cys Thr Ser
     450                 455                 460                
 Asn Val Ala Thr Thr Thr Leu Phe Leu Pro Ile Phe Ala Ser Met Ser
 465                 470                 475                 480
 Arg Ser Ile Gly Leu Asn Pro Leu Tyr Ile Met Leu Pro Cys Thr Leu
                 485                 490                 495    
 Ser Ala Ser Phe Ala Phe Met Leu Pro Val Ala Thr Pro Pro Asn Ala
             500                 505                 510        
 Ile Val Phe Thr Tyr Gly His Leu Lys Val Ala Asp Met Val Lys Thr
         515                 520                 525            
 Gly Val Ile Met Asn Ile Ile Gly Val Phe Cys Val Phe Leu Ala Val
     530                 535                 540                
 Asn Thr Trp Gly Arg Ala Ile Phe Asp Leu Asp His Phe Pro Asp Trp
 545                 550                 555                 560
 Ala Asn Val Thr His Ile Glu Thr
                 565            



      <210> 1061
      <211> 369
      <212> PRT
      <213> Homo sapiens


      <400> 1061
 Met Ile Arg Asn Trp Leu Thr Ile Phe Ile Leu Phe Pro Leu Lys Leu
   1               5                  10                  15    
 Val Glu Lys Cys Asp Ser Gln Pro Gln Glu Gly Asp Gln Cys Gln Glu
              20                  25                  30        
 Ser Ser Val Ser Leu Thr Val Pro Pro Val Val Lys Leu Glu Asn Gly
          35                  40                  45            
 Ser Ser Thr Asn Val Ser Leu Thr Leu Arg Pro Pro Leu Asn Ala Thr
      50                  55                  60                
 Leu Val Ile Thr Phe Glu Ile Thr Phe Arg Ser Lys Asn Ile Thr Ile
  65                  70                  75                  80
 Leu Glu Leu Pro Asp Glu Phe Gln Lys Gly Phe Ser Gly His Leu Thr
                  85                  90                  95    
 Asn Met Gln Ala Thr Leu Gln Gly Ile Ser Val Lys Asn Lys Lys Asn
             100                 105                 110        
 Pro Arg Ile Arg Phe Leu Val Ile Arg Ser Ser Ala Ile Ser Ile Ile
         115                 120                 125            
 Asn Gln Val Ile Gly Trp Ile Tyr Phe Val Ala Trp Ser Ile Ser Phe
     130                 135                 140                
 Tyr Pro Gln Val Ile Met Asn Trp Arg Arg Lys Ser Val Ile Gly Leu
 145                 150                 155                 160
 Ser Phe Asp Phe Val Ala Leu Asn Leu Thr Gly Phe Val Ala Tyr Ser
                 165                 170                 175    
 Val Phe Asn Ile Gly Leu Leu Trp Val Pro Tyr Ile Lys Glu Gln Phe
             180                 185                 190        
 Leu Leu Lys Tyr Pro Asn Gly Val Asn Pro Val Asn Ser Asn Asp Val
         195                 200                 205            
 Phe Phe Ser Leu His Ala Val Val Leu Thr Leu Ile Ile Ile Val Gln
     210                 215                 220                
 Cys Cys Leu Tyr Glu Arg Gly Gly Gln Arg Val Ser Trp Pro Ala Ile
 225                 230                 235                 240
 Gly Phe Leu Val Leu Ala Trp Leu Phe Ala Phe Val Thr Met Ile Val
                 245                 250                 255    
 Ala Ala Val Gly Val Ile Thr Trp Leu Gln Phe Leu Phe Cys Phe Ser
             260                 265                 270        
 Tyr Ile Lys Leu Ala Val Thr Leu Val Lys Tyr Phe Pro Gln Ala Tyr
         275                 280                 285            
 Met Asn Phe Tyr Tyr Lys Ser Thr Glu Gly Trp Ser Ile Gly Asn Val
     290                 295                 300                
 Leu Leu Asp Phe Thr Gly Gly Ser Phe Ser Leu Leu Gln Met Phe Leu
 305                 310                 315                 320
 Gln Ser Tyr Asn Asn Asp Gln Trp Thr Leu Ile Phe Gly Asp Pro Thr
                 325                 330                 335    
 Lys Phe Gly Leu Gly Val Phe Ser Ile Val Phe Asp Val Val Phe Phe
             340                 345                 350        
 Ile Gln His Phe Cys Leu Tyr Arg Lys Arg Pro Gly Tyr Asp Gln Leu
         355                 360                 365            
 Asn
    



      <210> 1062
      <211> 133
      <212> PRT
      <213> Homo sapiens


      <400> 1062
 Met Ala Ser Glu Val Val Cys Gly Leu Ile Phe Arg Leu Leu Leu Pro
   1               5                  10                  15    
 Ile Cys Leu Ala Val Ala Cys Ala Phe Arg Tyr Asn Gly Leu Ser Phe
              20                  25                  30        
 Val Tyr Leu Ile Tyr Leu Leu Leu Ile Pro Leu Phe Ser Glu Pro Thr
          35                  40                  45            
 Lys Thr Thr Met Gln Gly His Thr Gly Arg Leu Leu Lys Ser Leu Cys
      50                  55                  60                
 Phe Ile Ser Leu Ser Phe Leu Leu Leu His Ile Ile Phe His Ile Thr
  65                  70                  75                  80
 Leu Val Ser Leu Glu Ala Gln His Arg Ile Ala Pro Gly Tyr Asn Cys
                  85                  90                  95    
 Lys Lys Ser Gln Tyr Leu Asp Thr Ser Gly Gly Thr Ser Thr Ser Thr
             100                 105                 110        
 Met Lys Lys Gly Val Val Lys Gly Gly Asp Gly Glu Gly Arg Pro Ser
         115                 120                 125            
 Leu Pro Asn Gln Tyr
     130            



      <210> 1063
      <211> 255
      <212> PRT
      <213> Homo sapiens


      <400> 1063
 Met Arg Arg Ile Ser Leu Thr Ser Ser Pro Val Arg Leu Leu Leu Phe
   1               5                  10                  15    
 Leu Leu Leu Leu Leu Ile Ala Leu Glu Ile Met Val Gly Gly His Ser
              20                  25                  30        
 Leu Cys Phe Asn Phe Thr Ile Lys Ser Leu Ser Arg Pro Gly Gln Pro
          35                  40                  45            
 Trp Cys Glu Ala Gln Val Phe Leu Asn Lys Asn Leu Phe Leu Gln Tyr
      50                  55                  60                
 Asn Ser Asp Asn Asn Met Val Lys Pro Met Gly Leu Leu Gly Lys Lys
  65                  70                  75                  80
 Val Asn Ala Thr Ser Thr Trp Gly Glu Leu Thr Gln Thr Leu Gly Glu
                  85                  90                  95    
 Val Gly Arg Asp Leu Arg Met Leu Leu Cys Asp Ile Lys Pro Gln Ile
             100                 105                 110        
 Lys Thr Ser Asp Pro Ser Thr Leu Gln Val Glu Met Phe Cys Gln Arg
         115                 120                 125            
 Glu Ala Glu Arg Cys Thr Gly Ala Ser Trp Gln Phe Ala Thr Asn Gly
     130                 135                 140                
 Glu Lys Ser Leu Leu Phe Asp Ala Met Asn Met Thr Trp Thr Val Ile
 145                 150                 155                 160
 Asn His Glu Ala Ser Lys Ile Lys Glu Thr Trp Lys Lys Asp Arg Gly
                 165                 170                 175    
 Leu Glu Lys Tyr Phe Arg Lys Leu Ser Lys Gly Asp Cys Asp His Trp
             180                 185                 190        
 Leu Arg Glu Phe Leu Gly His Trp Glu Ala Met Pro Glu Pro Thr Val
         195                 200                 205            
 Ser Pro Val Asn Ala Ser Asp Ile His Trp Ser Ser Ser Ser Leu Pro
     210                 215                 220                
 Asp Arg Trp Ile Ile Leu Gly Ala Phe Ile Leu Leu Leu Leu Met Gly
 225                 230                 235                 240
 Ile Val Leu Ile Cys Val Trp Trp Gln Asn Gly Arg Arg Ser Thr
                 245                 250                 255



      <210> 1064
      <211> 350
      <212> PRT
      <213> Homo sapiens


      <400> 1064
 Met Ala Pro Thr Gln Gly Pro Arg Ala Pro Leu Glu Phe Gly Gly Pro
   1               5                  10                  15    
 Leu Gly Ala Ala Ala Leu Leu Leu Leu Leu Pro Ala Thr Met Phe His
              20                  25                  30        
 Leu Leu Leu Ala Ala Arg Ser Gly Pro Ala Arg Leu Leu Gly Pro Pro
          35                  40                  45            
 Ala Ser Leu Pro Gly Leu Glu Val Leu Trp Ser Pro Arg Ala Leu Leu
      50                  55                  60                
 Leu Trp Leu Ala Trp Leu Gly Leu Gln Ala Ala Leu Tyr Leu Leu Pro
  65                  70                  75                  80
 Ala Arg Lys Val Ala Glu Gly Gln Glu Leu Lys Asp Lys Ser Arg Leu
                  85                  90                  95    
 Arg Tyr Pro Ile Asn Gly Phe Gln Ala Leu Val Leu Thr Ala Leu Leu
             100                 105                 110        
 Val Gly Leu Gly Met Ser Ala Gly Leu Pro Leu Gly Ala Leu Pro Glu
         115                 120                 125            
 Met Leu Leu Pro Leu Ala Phe Val Ala Thr Leu Thr Ala Phe Ile Phe
     130                 135                 140                
 Ser Leu Phe Leu Tyr Met Lys Ala Gln Val Ala Pro Val Ser Ala Leu
 145                 150                 155                 160
 Ala Pro Gly Gly Asn Ser Gly Asn Pro Ile Tyr Asp Phe Phe Leu Gly
                 165                 170                 175    
 Arg Glu Leu Asn Pro Arg Ile Cys Phe Phe Asp Phe Lys Tyr Phe Cys
             180                 185                 190        
 Glu Leu Arg Pro Gly Leu Ile Gly Trp Val Leu Ile Asn Leu Ala Leu
         195                 200                 205            
 Leu Met Lys Glu Ala Glu Leu Arg Gly Ser Pro Ser Leu Ala Met Trp
     210                 215                 220                
 Leu Val Asn Gly Phe Gln Leu Leu Tyr Val Gly Asp Ala Leu Trp His
 225                 230                 235                 240
 Glu Glu Ala Val Leu Thr Thr Met Asp Ile Thr His Asp Gly Phe Gly
                 245                 250                 255    
 Phe Met Leu Ala Phe Gly Asp Met Ala Trp Val Pro Phe Thr Tyr Ser
             260                 265                 270        
 Leu Gln Ala Gln Phe Leu Leu His His Pro Gln Pro Leu Gly Leu Pro
         275                 280                 285            
 Met Ala Ser Val Ile Cys Leu Ile Asn Gly Val Ser His Leu Leu Pro
     290                 295                 300                
 Tyr Phe Tyr Leu Leu Tyr Phe Thr Ala Leu Leu Val His Arg Glu Ala
 305                 310                 315                 320
 Arg Asp Glu Arg Gln Cys Leu Gln Lys Tyr Gly Leu Ala Trp Gln Glu
                 325                 330                 335    
 Tyr Cys Arg Arg Val Pro Tyr Arg Ile Met Pro Tyr Ile Tyr
             340                 345                 350



      <210> 1065
      <211> 983
      <212> PRT
      <213> Homo sapiens


      <400> 1065
 Met Arg Leu Gly Ser Gly Thr Phe Ala Thr Cys Cys Val Ala Ile Glu
   1               5                  10                  15    
 Val Leu Gly Ile Ala Val Phe Leu Arg Gly Phe Phe Pro Ala Pro Val
              20                  25                  30        
 Arg Ser Ser Ala Arg Ala Glu His Gly Ala Glu Pro Pro Ala Pro Glu
          35                  40                  45            
 Pro Ser Ala Gly Ala Ser Ser Asn Trp Thr Thr Leu Pro Pro Pro Leu
      50                  55                  60                
 Phe Ser Lys Val Val Ile Val Leu Ile Asp Ala Leu Arg Asp Asp Phe
  65                  70                  75                  80
 Val Phe Gly Ser Lys Gly Val Lys Phe Met Pro Tyr Thr Thr Tyr Leu
                  85                  90                  95    
 Val Glu Lys Gly Ala Ser His Ser Phe Val Ala Glu Ala Lys Pro Pro
             100                 105                 110        
 Thr Val Thr Met Pro Arg Ile Lys Ala Leu Met Thr Gly Ser Leu Pro
         115                 120                 125            
 Gly Phe Val Asp Val Ile Arg Asn Leu Asn Ser Pro Ala Leu Leu Glu
     130                 135                 140                
 Asp Ser Val Ile Arg Gln Ala Lys Ala Ala Gly Lys Arg Ile Val Phe
 145                 150                 155                 160
 Tyr Gly Asp Glu Thr Trp Val Lys Leu Phe Pro Lys His Phe Val Glu
                 165                 170                 175    
 Tyr Asp Gly Thr Thr Ser Phe Phe Val Ser Asp Tyr Thr Glu Val Asp
             180                 185                 190        
 Asn Asn Val Thr Arg His Leu Asp Lys Val Leu Lys Arg Gly Asp Trp
         195                 200                 205            
 Asp Ile Leu Ile Leu His Tyr Leu Gly Leu Asp His Ile Gly His Ile
     210                 215                 220                
 Ser Gly Pro Asn Ser Pro Leu Ile Gly Gln Lys Leu Ser Glu Met Asp
 225                 230                 235                 240
 Ser Val Leu Met Lys Ile His Thr Ser Leu Gln Ser Lys Glu Arg Glu
                 245                 250                 255    
 Thr Pro Leu Pro Asn Leu Leu Val Leu Cys Gly Asp His Gly Met Ser
             260                 265                 270        
 Glu Thr Gly Ser His Gly Ala Ser Ser Thr Glu Glu Gly Asn Thr Pro
         275                 280                 285            
 Leu Ile Leu Ile Ser Ser Ala Phe Glu Arg Lys Pro Gly Asp Ile Arg
     290                 295                 300                
 His Pro Lys His Val Gln Gln Thr Asp Val Ala Ala Thr Leu Ala Ile
 305                 310                 315                 320
 Ala Leu Gly Leu Pro Ile Pro Lys Asp Ser Val Gly Ser Leu Leu Phe
                 325                 330                 335    
 Pro Val Val Glu Gly Arg Pro Met Arg Glu Gln Leu Arg Phe Leu His
             340                 345                 350        
 Leu Asn Thr Val Gln Leu Ile Lys Leu Leu Gln Glu Asn Val Pro Ser
         355                 360                 365            
 Tyr Glu Lys Asp Pro Gly Phe Glu Gln Phe Lys Met Ser Glu Arg Leu
     370                 375                 380                
 His Gly Asn Trp Ile Arg Leu Tyr Leu Glu Glu Lys His Ser Glu Val
 385                 390                 395                 400
 Leu Phe Asn Leu Gly Ser Lys Val Leu Arg Gln Tyr Leu Asp Ala Leu
                 405                 410                 415    
 Lys Thr Leu Ser Leu Ser Leu Ser Ala Gln Val Ala Gln Tyr Asp Ile
             420                 425                 430        
 Tyr Ser Met Met Val Gly Thr Val Val Val Leu Glu Val Leu Thr Leu
         435                 440                 445            
 Leu Leu Leu Ser Val Pro Gln Ala Leu Arg Arg Lys Ala Glu Leu Glu
     450                 455                 460                
 Val Pro Leu Ser Ser Pro Gly Phe Ser Leu Leu Phe Tyr Leu Val Ile
 465                 470                 475                 480
 Leu Val Leu Ser Ala Val His Val Ile Val Cys Thr Ser Ala Glu Ser
                 485                 490                 495    
 Ser Cys Tyr Phe Cys Gly Leu Ser Trp Leu Ala Ala Gly Gly Val Met
             500                 505                 510        
 Val Leu Ala Ser Ala Leu Leu Cys Val Ile Val Ser Val Leu Thr Asn
         515                 520                 525            
 Val Leu Val Gly Gly Asn Thr Pro Arg Lys Asn Pro Met His Pro Ser
     530                 535                 540                
 Ser Arg Trp Ser Glu Leu Asp Leu Leu Ile Leu Leu Gly Thr Ala Gly
 545                 550                 555                 560
 His Val Leu Ser Leu Gly Ala Ser Ser Phe Val Glu Glu Glu His Gln
                 565                 570                 575    
 Thr Trp Tyr Phe Leu Val Asn Thr Leu Cys Leu Ala Leu Ser Gln Glu
             580                 585                 590        
 Thr Tyr Arg Asn Tyr Phe Leu Gly Asp Asp Gly Glu Pro Pro Cys Gly
         595                 600                 605            
 Leu Cys Val Glu Gln Gly His Asp Gly Ala Thr Ala Ala Trp Gln Asp
     610                 615                 620                
 Gly Pro Gly Cys Asp Val Leu Glu Arg Asp Lys Gly His Gly Ser Pro
 625                 630                 635                 640
 Ser Thr Ser Glu Val Leu Arg Gly Arg Glu Lys Trp Met Val Leu Ala
                 645                 650                 655    
 Ser Pro Trp Leu Ile Leu Ala Cys Cys Arg Leu Leu Arg Ser Leu Asn
             660                 665                 670        
 Gln Thr Gly Val Gln Trp Ala His Arg Pro Asp Leu Gly His Trp Leu
         675                 680                 685            
 Thr Ser Ser Asp His Lys Ala Glu Leu Ser Val Leu Ala Ala Leu Ser
     690                 695                 700                
 Leu Leu Val Val Phe Val Leu Val Gln Arg Gly Cys Ser Pro Val Ser
 705                 710                 715                 720
 Lys Ala Ala Leu Ala Leu Gly Leu Leu Gly Val Tyr Cys Tyr Arg Ala
                 725                 730                 735    
 Ala Ile Gly Ser Val Arg Phe Pro Trp Arg Pro Asp Ser Lys Asp Ile
             740                 745                 750        
 Ser Lys Gly Ile Ile Glu Ala Arg Phe Val Tyr Val Phe Val Leu Gly
         755                 760                 765            
 Ile Leu Phe Thr Gly Thr Lys Asp Leu Leu Lys Ser Gln Val Ile Ala
     770                 775                 780                
 Ala Asp Phe Lys Leu Lys Thr Val Gly Leu Trp Glu Ile Tyr Ser Gly
 785                 790                 795                 800
 Leu Val Leu Leu Ala Ala Leu Leu Phe Arg Pro His Asn Leu Pro Val
                 805                 810                 815    
 Leu Ala Phe Ser Leu Leu Ile Gln Thr Leu Met Thr Lys Phe Ile Trp
             820                 825                 830        
 Lys Pro Leu Arg His Asp Ala Ala Glu Ile Thr Val Met His Tyr Trp
         835                 840                 845            
 Phe Gly Gln Ala Phe Phe Tyr Phe Gln Gly Asn Ser Asn Asn Ile Ala
     850                 855                 860                
 Thr Val Asp Ile Ser Ala Gly Phe Val Gly Leu Asp Thr Tyr Val Glu
 865                 870                 875                 880
 Ile Pro Ala Val Leu Leu Thr Ala Phe Gly Thr Tyr Ala Gly Pro Val
                 885                 890                 895    
 Leu Trp Ala Ser His Leu Val His Phe Leu Ser Ser Glu Thr Arg Ser
             900                 905                 910        
 Gly Ser Ala Leu Ser His Ala Cys Phe Cys Tyr Ala Leu Ile Cys Ser
         915                 920                 925            
 Ile Pro Val Phe Thr Tyr Ile Val Leu Val Thr Ser Leu Arg Tyr His
     930                 935                 940                
 Leu Phe Ile Trp Ser Val Phe Ser Pro Lys Leu Leu Tyr Glu Gly Met
 945                 950                 955                 960
 His Leu Leu Ile Thr Ala Ala Val Cys Val Phe Phe Thr Ala Met Asp
                 965                 970                 975    
 Gln Thr Arg Leu Thr Gln Ser
             980            



      <210> 1066
      <211> 376
      <212> PRT
      <213> Homo sapiens


      <400> 1066
 Met Asn Val Ala Ile Phe Arg Thr Gly Pro Met Leu Leu Trp Thr Ala
   1               5                  10                  15    
 Val Leu Leu Phe Val Pro Cys Val Gly Lys Thr Val Trp Leu Tyr Leu
              20                  25                  30        
 Gln Ala Trp Pro Asn Pro Val Phe Glu Gly Asp Ala Leu Thr Leu Arg
          35                  40                  45            
 Cys Gln Gly Trp Lys Asn Thr Pro Leu Ser Gln Val Lys Phe Tyr Arg
      50                  55                  60                
 Asp Gly Lys Phe Leu His Phe Ser Lys Glu Asn Gln Thr Leu Ser Met
  65                  70                  75                  80
 Gly Ala Ala Thr Val Gln Ser Arg Gly Gln Tyr Ser Cys Ser Gly Gln
                  85                  90                  95    
 Val Met Tyr Ile Pro Gln Thr Phe Thr Gln Thr Ser Glu Thr Ala Met
             100                 105                 110        
 Val Gln Val Gln Glu Leu Phe Pro Pro Pro Val Leu Ser Ala Ile Pro
         115                 120                 125            
 Ser Pro Glu Pro Arg Glu Gly Ser Leu Val Thr Leu Arg Cys Gln Thr
     130                 135                 140                
 Lys Leu His Pro Leu Arg Ser Ala Leu Arg Leu Leu Phe Ser Phe His
 145                 150                 155                 160
 Lys Asp Gly His Thr Leu Gln Asp Arg Gly Pro His Pro Glu Leu Cys
                 165                 170                 175    
 Ile Pro Gly Ala Lys Glu Gly Asp Ser Gly Leu Tyr Trp Cys Glu Val
             180                 185                 190        
 Ala Pro Glu Gly Gly Gln Val Gln Lys Gln Ser Pro Gln Leu Glu Val
         195                 200                 205            
 Arg Val Gln Ala Pro Val Ser Arg Pro Val Leu Thr Leu His His Gly
     210                 215                 220                
 Pro Ala Asp Pro Ala Val Gly Asp Met Val Gln Leu Leu Cys Glu Ala
 225                 230                 235                 240
 Gln Arg Gly Ser Pro Pro Ile Leu Tyr Ser Phe Tyr Leu Asp Glu Lys
                 245                 250                 255    
 Ile Val Gly Asn His Ser Ala Pro Cys Gly Gly Thr Thr Ser Leu Leu
             260                 265                 270        
 Phe Pro Val Lys Ser Glu Gln Asp Ala Gly Asn Tyr Ser Cys Glu Ala
         275                 280                 285            
 Glu Asn Ser Val Ser Arg Glu Arg Ser Glu Pro Lys Lys Leu Ser Leu
     290                 295                 300                
 Lys Gly Ser Gln Val Leu Phe Thr Pro Ala Ser Asn Trp Leu Val Pro
 305                 310                 315                 320
 Trp Leu Pro Ala Ser Leu Leu Gly Leu Met Val Asn Ala Ala Ala Leu
                 325                 330                 335    
 Leu Val Tyr Val Arg Ser Trp Arg Lys Ala Gly Pro Leu Pro Ser Gln
             340                 345                 350        
 Ile Pro Pro Thr Ala Pro Gly Gly Glu Gln Cys Pro Leu Tyr Ala Lys
         355                 360                 365            
 Glu Pro Ala Ser Cys Trp Arg Glu
     370                 375    



      <210> 1067
      <211> 292
      <212> PRT
      <213> Homo sapiens


      <400> 1067
 Met Gly Ile Pro Ser Leu Pro Lys Ser Leu Phe Leu Pro Ile Phe Phe
   1               5                  10                  15    
 Val Phe Leu Leu Leu Tyr Val Leu Ile Leu Met Gly Asn Thr Phe Ile
              20                  25                  30        
 Leu Val Ala Val Val Ala Lys Pro Ser Leu His Lys Pro Met Tyr Phe
          35                  40                  45            
 Phe Leu Ile Asn Leu Ser Thr Leu Asp Ile Leu Val Thr Thr Thr Thr
      50                  55                  60                
 Val Pro Lys Met Leu Ser Leu Phe Leu Phe Gly Asp Ser Phe Leu Ser
  65                  70                  75                  80
 Phe Pro Ala Cys Phe Leu Gln Met Tyr Leu Phe His Ser Phe Ser Cys
                  85                  90                  95    
 Ser Glu Ala Phe Ile Leu Val Val Met Ala Tyr Asp Arg Tyr Val Ala
             100                 105                 110        
 Ile Cys Arg Pro Leu His Tyr Pro Val Leu Met Thr Pro Gln Thr Asn
         115                 120                 125            
 Thr Val Leu Thr Thr Ser Ala Trp Leu Thr Ala Leu Leu Leu Pro Ile
     130                 135                 140                
 Pro Ala Val Val Gln Thr Ser Gln Met Ala Phe Asp Ile Ile Val His
 145                 150                 155                 160
 Ile Tyr His Cys Phe Cys Asp His Leu Ala Val Thr Phe Met Gly Phe
                 165                 170                 175    
 Cys Ile Ala Met Val Val Ser Phe Leu Pro Leu Leu Leu Val Leu Leu
             180                 185                 190        
 Ser Tyr Ala His Ile Leu Thr Ser Val Leu Cys Ile Asn Cys Gln Glu
         195                 200                 205            
 Gly Arg Ser Lys Ala Phe Ser Thr Cys Ser Ser His Leu Leu Val Val
     210                 215                 220                
 Gly Thr Tyr Tyr Ser Ser Ile Ala Ile Ala Tyr Val Ala Tyr Arg Ala
 225                 230                 235                 240
 Asp Leu Pro Leu Asp Phe His Val Met Gly Asn Val Val Tyr Ala Ile
                 245                 250                 255    
 Leu Thr Pro Val Leu Asn Pro Val Ile Tyr Lys Leu Arg Asn Lys Asp
             260                 265                 270        
 Val Lys Ala Ala Ile Thr Lys Ile Ala Cys Pro Gln Glu Pro Lys Asn
         275                 280                 285            
 Ala Arg Lys Pro
     290        



      <210> 1068
      <211> 113
      <212> PRT
      <213> Homo sapiens


      <400> 1068
 Met Asp Lys Pro Leu Phe Pro Leu Val Pro Leu His Trp Phe Gly Phe
   1               5                  10                  15    
 Gly Tyr Thr Ala Leu Val Val Ser Gly Gly Ile Val Gly Tyr Val Lys
              20                  25                  30        
 Thr Gly Ser Val Pro Ser Leu Ala Ala Gly Leu Leu Phe Gly Ser Leu
          35                  40                  45            
 Ala Gly Leu Gly Ala Tyr Gln Leu Ser Gln Asp Pro Arg Asn Val Trp
      50                  55                  60                
 Val Phe Leu Ala Thr Ser Gly Thr Leu Ala Gly Ile Met Gly Met Arg
  65                  70                  75                  80
 Phe Tyr His Ser Gly Lys Phe Met Pro Ala Gly Leu Ile Ala Gly Ala
                  85                  90                  95    
 Ser Leu Leu Met Val Ala Lys Val Gly Val Ser Met Phe Asn Arg Pro
             100                 105                 110        
 His
    



      <210> 1069
      <211> 592
      <212> PRT
      <213> Homo sapiens


      <400> 1069
 Met Val Asp Gly Val Met Ile Leu Pro Val Leu Ile Met Ile Ala Leu
   1               5                  10                  15    
 Pro Ser Pro Ser Met Glu Asp Glu Lys Pro Lys Val Asn Pro Lys Leu
              20                  25                  30        
 Tyr Met Cys Val Cys Glu Gly Leu Ser Cys Gly Asn Glu Asp His Cys
          35                  40                  45            
 Glu Gly Gln Gln Cys Phe Ser Ser Leu Ser Ile Asn Asp Gly Phe His
      50                  55                  60                
 Val Tyr Gln Lys Gly Cys Phe Gln Val Tyr Glu Gln Gly Lys Met Thr
  65                  70                  75                  80
 Cys Lys Thr Pro Pro Ser Pro Gly Gln Ala Val Glu Cys Cys Gln Gly
                  85                  90                  95    
 Asp Trp Cys Asn Arg Asn Ile Thr Ala Gln Leu Pro Thr Lys Gly Lys
             100                 105                 110        
 Ser Phe Pro Gly Thr Gln Asn Phe His Leu Glu Val Gly Leu Ile Ile
         115                 120                 125            
 Leu Ser Val Val Phe Ala Val Cys Leu Leu Ala Cys Leu Leu Gly Val
     130                 135                 140                
 Ala Leu Arg Lys Phe Lys Arg Arg Asn Gln Glu Arg Leu Asn Pro Arg
 145                 150                 155                 160
 Asp Val Glu Tyr Gly Thr Ile Glu Gly Leu Ile Thr Thr Asn Val Gly
                 165                 170                 175    
 Asp Ser Thr Leu Ala Gly Ser Lys Phe Leu Pro Leu Asp Ala Gln Leu
             180                 185                 190        
 Leu Val Ile Leu Pro Ile Asn Ser Thr Ser Gln Trp Cys Ser Glu Glu
         195                 200                 205            
 Val Lys Glu Asp Glu Ile His Thr Asn Gln Cys Ile Ala Leu Arg Ser
     210                 215                 220                
 Phe Thr Cys Thr Leu Thr Gly His Val Ser Arg Ile Ala Ala Leu His
 225                 230                 235                 240
 Val Tyr Gly Tyr Cys His Cys Leu Leu Leu Leu Ala Ser Pro Pro Arg
                 245                 250                 255    
 Gln Ile Val Asn Gly Glu Asn Lys Asp Gly Lys Ala Pro Asn Val Leu
             260                 265                 270        
 Ile Asn Phe Asn Gln Ser Cys Pro Leu Val Leu Thr Ser Ile Leu Phe
         275                 280                 285            
 Asp Tyr Glu Gln Asp Tyr Leu Asp Ser Gly Lys Gly Arg Tyr Gly Glu
     290                 295                 300                
 Val Trp Arg Gly Ser Trp Gln Gly Glu Asn Val Ala Val Lys Ile Phe
 305                 310                 315                 320
 Ser Ser Arg Asp Glu Lys Ser Trp Phe Arg Glu Thr Glu Leu Tyr Asn
                 325                 330                 335    
 Thr Val Met Leu Arg His Glu Asn Ile Leu Gly Phe Ile Ala Ser Asp
             340                 345                 350        
 Met Thr Ser Arg His Ser Ser Thr Gln Leu Trp Leu Ile Thr His Tyr
         355                 360                 365            
 His Glu Met Gly Ser Leu Tyr Asp Tyr Leu Gln Leu Thr Thr Leu Asp
     370                 375                 380                
 Thr Val Ser Cys Leu Arg Ile Val Leu Ser Ile Ala Ser Gly Leu Ala
 385                 390                 395                 400
 His Leu His Ile Glu Ile Phe Gly Thr Gln Gly Lys Pro Ala Ile Ala
                 405                 410                 415    
 His Arg Asp Leu Lys Ser Lys Asn Ile Leu Val Lys Lys Asn Gly Gln
             420                 425                 430        
 Cys Cys Ile Ala Asp Leu Gly Leu Ala Val Met His Ser Gln Ser Thr
         435                 440                 445            
 Asn Gln Leu Asp Val Gly Asn Asn Pro Arg Val Gly Thr Lys Arg Tyr
     450                 455                 460                
 Met Ala Pro Glu Val Leu Asp Glu Thr Ile Gln Val Asp Cys Phe Asp
 465                 470                 475                 480
 Ser Tyr Lys Arg Val Asp Ile Trp Ala Phe Gly Leu Val Leu Trp Glu
                 485                 490                 495    
 Val Ala Arg Arg Met Val Ser Asn Gly Ile Val Glu Asp Tyr Lys Pro
             500                 505                 510        
 Pro Phe Tyr Asp Val Val Pro Asn Asp Pro Ser Phe Glu Asp Met Arg
         515                 520                 525            
 Lys Val Val Cys Val Asp Gln Gln Arg Pro Asn Ile Pro Asn Arg Trp
     530                 535                 540                
 Phe Ser Asp Pro Thr Leu Thr Ser Leu Ala Lys Leu Met Lys Glu Cys
 545                 550                 555                 560
 Trp Tyr Gln Asn Pro Ser Ala Arg Leu Thr Ala Leu Arg Ile Lys Lys
                 565                 570                 575    
 Thr Leu Thr Lys Ile Asp Asn Ser Leu Asp Lys Leu Lys Thr Asp Cys
             580                 585                 590        





      <210> 1070
      <211> 292
      <212> PRT
      <213> Homo sapiens


      <400> 1070
 Met Arg Thr Pro Val Val Met Thr Leu Gly Met Val Leu Ala Pro Cys
   1               5                  10                  15    
 Gly Leu Leu Leu Asn Leu Thr Gly Thr Leu Ala Pro Gly Trp Arg Leu
              20                  25                  30        
 Val Lys Gly Phe Leu Asn Gln Pro Val Asp Val Glu Leu Tyr Gln Gly
          35                  40                  45            
 Leu Trp Asp Met Cys Arg Glu Gln Ser Ser Arg Glu Arg Glu Cys Gly
      50                  55                  60                
 Gln Thr Asp Gln Trp Gly Tyr Phe Glu Ala Gln Pro Val Leu Val Ala
  65                  70                  75                  80
 Arg Ala Leu Met Val Thr Ser Leu Ala Ala Thr Val Leu Gly Leu Leu
                  85                  90                  95    
 Leu Ala Ser Leu Gly Val Arg Cys Trp Gln Asp Glu Pro Asn Phe Val
             100                 105                 110        
 Leu Ala Gly Leu Ser Gly Val Val Leu Phe Val Ala Gly Leu Leu Gly
         115                 120                 125            
 Leu Ile Pro Val Ser Trp Tyr Asn His Phe Leu Gly Asp Arg Asp Val
     130                 135                 140                
 Leu Pro Ala Pro Ala Ser Pro Val Thr Val Gln Val Ser Tyr Ser Leu
 145                 150                 155                 160
 Val Leu Gly Tyr Leu Gly Ser Cys Leu Leu Leu Leu Gly Gly Phe Ser
                 165                 170                 175    
 Leu Ala Leu Ser Phe Ala Pro Trp Cys Asp Glu Arg Cys Arg Arg Arg
             180                 185                 190        
 Arg Lys Gly Pro Ser Ala Gly Pro Arg Arg Ser Ser Val Ser Thr Ile
         195                 200                 205            
 Gln Val Glu Trp Pro Glu Pro Asp Leu Ala Pro Ala Ile Lys Tyr Tyr
     210                 215                 220                
 Ser Asp Gly Gln His Arg Pro Pro Pro Ala Gln His Arg Lys Pro Lys
 225                 230                 235                 240
 Pro Lys Pro Lys Val Gly Phe Pro Met Pro Arg Pro Arg Pro Lys Ala
                 245                 250                 255    
 Tyr Thr Asn Ser Val Asp Val Leu Asp Gly Glu Gly Trp Glu Ser Gln
             260                 265                 270        
 Asp Ala Pro Ser Cys Ser Thr His Pro Cys Asp Ser Ser Leu Pro Cys
         275                 280                 285            
 Asp Ser Asp Leu
     290        



      <210> 1071
      <211> 383
      <212> PRT
      <213> Homo sapiens


      <400> 1071
 Met Gly Leu Gly Pro Val Phe Leu Leu Leu Ala Gly Ile Phe Pro Phe
   1               5                  10                  15    
 Ala Pro Pro Gly Ala Ala Ala Glu Pro His Ser Leu Arg Tyr Asn Leu
              20                  25                  30        
 Thr Val Leu Ser Trp Asp Gly Ser Val Gln Ser Gly Phe Leu Ala Glu
          35                  40                  45            
 Val His Leu Asp Gly Gln Pro Phe Leu Arg Tyr Asp Arg Gln Lys Cys
      50                  55                  60                
 Arg Ala Lys Pro Gln Gly Gln Trp Ala Glu Asp Val Leu Gly Asn Lys
  65                  70                  75                  80
 Thr Trp Asp Arg Glu Thr Arg Asp Leu Thr Gly Asn Gly Lys Asp Leu
                  85                  90                  95    
 Arg Met Thr Leu Ala His Ile Lys Asp Gln Lys Glu Gly Leu His Ser
             100                 105                 110        
 Leu Gln Glu Ile Arg Val Cys Glu Ile His Glu Asp Asn Ser Thr Arg
         115                 120                 125            
 Ser Ser Gln His Phe Tyr Tyr Asp Gly Glu Leu Phe Leu Ser Gln Asn
     130                 135                 140                
 Val Glu Thr Glu Glu Trp Thr Val Pro Gln Ser Ser Arg Ala Gln Thr
 145                 150                 155                 160
 Leu Ala Met Asn Val Arg Asn Phe Leu Lys Glu Asp Ala Met Lys Thr
                 165                 170                 175    
 Lys Thr His Tyr His Ala Met His Ala Asp Cys Leu Gln Glu Leu Arg
             180                 185                 190        
 Arg Tyr Leu Glu Ser Ser Val Val Leu Arg Arg Arg Val Pro Pro Met
         195                 200                 205            
 Val Asn Val Thr Arg Ser Glu Ala Ser Glu Gly Asn Ile Thr Val Thr
     210                 215                 220                
 Cys Arg Ala Ser Ser Phe Tyr Pro Arg Asn Ile Thr Leu Thr Trp Arg
 225                 230                 235                 240
 Gln Asp Gly Val Ser Leu Ser His Asp Thr Gln Gln Trp Gly Asp Val
                 245                 250                 255    
 Leu Pro Asp Gly Asn Gly Thr Tyr Gln Thr Trp Val Ala Thr Arg Ile
             260                 265                 270        
 Arg Gln Gly Glu Glu Gln Arg Phe Thr Cys Tyr Met Glu His Ser Gly
         275                 280                 285            
 Asn His Gly Thr His Pro Val Pro Ser Gly Lys Ala Leu Val Leu Gln
     290                 295                 300                
 Ser Gln Arg Thr Asp Phe Pro Tyr Val Ser Ala Ala Met Pro Cys Phe
 305                 310                 315                 320
 Val Ile Ile Ile Ile Leu Cys Val Pro Cys Cys Lys Lys Lys Thr Ser
                 325                 330                 335    
 Ala Ala Glu Gly Pro Glu Leu Val Ser Leu Gln Val Leu Asp Gln His
             340                 345                 350        
 Pro Val Gly Thr Gly Asp His Arg Asp Ala Ala Gln Leu Gly Phe Gln
         355                 360                 365            
 Pro Leu Met Ser Ala Thr Gly Ser Thr Gly Ser Thr Glu Gly Ala
     370                 375                 380            



      <210> 1072
      <211> 232
      <212> PRT
      <213> Homo sapiens


      <400> 1072
 Met Pro Gly Ala Ala Ala Ala Ala Ala Ala Ala Ala Ala Ala Met Leu
   1               5                  10                  15    
 Pro Ala Gln Glu Ala Ala Lys Leu Tyr His Thr Asn Tyr Val Arg Asn
              20                  25                  30        
 Ser Arg Ala Ile Gly Val Leu Trp Ala Ile Phe Thr Ile Cys Phe Ala
          35                  40                  45            
 Ile Val Asn Val Val Cys Phe Ile Gln Pro Tyr Trp Ile Gly Asp Gly
      50                  55                  60                
 Val Asp Thr Pro Gln Ala Gly Tyr Phe Gly Leu Phe His Tyr Cys Ile
  65                  70                  75                  80
 Gly Asn Gly Phe Ser Arg Glu Leu Thr Cys Arg Gly Ser Phe Thr Asp
                  85                  90                  95    
 Phe Ser Thr Leu Pro Ser Gly Ala Phe Lys Ala Ala Ser Phe Phe Ile
             100                 105                 110        
 Gly Leu Ser Met Met Leu Ile Ile Ala Cys Ile Ile Cys Phe Thr Leu
         115                 120                 125            
 Phe Phe Phe Cys Asn Thr Ala Thr Val Tyr Lys Ile Cys Ala Trp Met
     130                 135                 140                
 Gln Leu Thr Ser Ala Ala Cys Leu Val Leu Gly Cys Met Ile Phe Pro
 145                 150                 155                 160
 Asp Gly Trp Asp Ser Asp Glu Val Lys Arg Met Cys Gly Glu Lys Thr
                 165                 170                 175    
 Asp Lys Tyr Thr Leu Gly Ala Cys Ser Val Arg Trp Ala Tyr Ile Leu
             180                 185                 190        
 Ala Ile Ile Gly Ile Leu Asp Ala Leu Ile Leu Ser Phe Leu Ala Phe
         195                 200                 205            
 Val Leu Gly Asn Arg Gln Asp Ser Leu Met Ala Glu Glu Leu Lys Ala
     210                 215                 220                
 Glu Asn Lys Asp Asp Gly Asn Ala
 225                 230        



      <210> 1073
      <211> 575
      <212> PRT
      <213> Homo sapiens


      <400> 1073
 Met Ser Val Glu Pro Pro Pro Glu Leu Glu Glu Lys Ala Ala Ser Glu
   1               5                  10                  15    
 Pro Glu Ala Gly Ala Met Pro Glu Lys Arg Ala Gly Ala Gln Ala Ala
              20                  25                  30        
 Gly Ser Thr Trp Leu Gln Gly Phe Gly Pro Pro Ser Val Tyr His Ala
          35                  40                  45            
 Ala Ile Val Ile Phe Leu Glu Phe Phe Ala Trp Gly Leu Leu Thr Thr
      50                  55                  60                
 Pro Met Leu Thr Val Leu His Glu Thr Phe Ser Gln His Thr Phe Leu
  65                  70                  75                  80
 Met Asn Gly Leu Ile Gln Gly Val Lys Pro Leu Trp Pro Ser Asp Pro
                  85                  90                  95    
 Pro Gly Leu Ala Thr Asn Asn Lys Tyr Ser Leu Ser His Arg Cys Ser
             100                 105                 110        
 Phe Trp Gly Leu Val Tyr Ser Val Gln Lys Asp Thr Leu Arg Lys Lys
         115                 120                 125            
 Lys Gly Leu Leu Ser Phe Leu Ser Ala Pro Leu Ile Gly Ala Leu Ser
     130                 135                 140                
 Asp Val Trp Gly Arg Lys Pro Phe Leu Leu Gly Thr Val Phe Phe Thr
 145                 150                 155                 160
 Cys Phe Pro Ile Pro Leu Met Arg Ile Ser Pro Trp Trp Tyr Phe Ala
                 165                 170                 175    
 Met Ile Ser Val Ser Gly Val Phe Ser Val Thr Phe Ser Val Ile Phe
             180                 185                 190        
 Ala Tyr Val Ala Asp Val Thr Gln Glu His Glu Arg Ser Thr Ala Tyr
         195                 200                 205            
 Gly Trp Val Ser Ala Thr Phe Ala Ala Ser Leu Val Ser Ser Pro Ala
     210                 215                 220                
 Ile Gly Ala Tyr Leu Ser Ala Ser Tyr Gly Asp Ser Leu Val Val Leu
 225                 230                 235                 240
 Val Ala Thr Val Val Ala Leu Leu Asp Ile Cys Phe Ile Leu Val Ala
                 245                 250                 255    
 Val Pro Glu Ser Leu Pro Glu Lys Met Arg Pro Val Ser Trp Gly Ala
             260                 265                 270        
 Gln Ile Ser Trp Lys Gln Ala Asp Pro Phe Ala Ile Lys Ile Met Lys
         275                 280                 285            
 Leu Met Phe Gln Asn Ile Gly Asn Ile Asn Val Tyr Trp His Phe Lys
     290                 295                 300                
 Cys Val Leu Ser Ala Tyr Ser Gln Ser Leu Lys Lys Val Gly Lys Asp
 305                 310                 315                 320
 Ser Thr Val Leu Leu Ile Cys Ile Thr Val Phe Leu Ser Tyr Leu Pro
                 325                 330                 335    
 Glu Ala Gly Gln Tyr Ser Ser Phe Phe Leu Tyr Leu Arg Gln Val Ile
             340                 345                 350        
 Gly Phe Gly Ser Val Lys Ile Ala Ala Phe Ile Ala Met Val Gly Ile
         355                 360                 365            
 Leu Ser Ile Val Ala Gln Thr Ala Phe Leu Ser Ile Leu Met Arg Ser
     370                 375                 380                
 Leu Gly Asn Lys Asn Thr Val Leu Leu Gly Leu Gly Phe Gln Met Leu
 385                 390                 395                 400
 Gln Leu Ala Trp Tyr Gly Phe Gly Ser Gln Ala Trp Met Met Trp Ala
                 405                 410                 415    
 Ala Gly Thr Val Ala Ala Met Ser Ser Ile Thr Phe Pro Ala Ile Ser
             420                 425                 430        
 Ala Leu Val Ser Arg Asn Ala Glu Ser Asp Gln Gln Gly Val Ala Gln
         435                 440                 445            
 Gly Ile Ile Thr Gly Ile Arg Gly Leu Cys Asn Gly Leu Gly Pro Ala
     450                 455                 460                
 Leu Tyr Gly Phe Ile Phe Tyr Met Phe His Val Glu Leu Thr Glu Leu
 465                 470                 475                 480
 Gly Pro Lys Leu Asn Ser Asn Asn Val Pro Leu Gln Gly Ala Val Ile
                 485                 490                 495    
 Pro Gly Pro Pro Phe Leu Phe Gly Ala Cys Ile Val Leu Met Ser Phe
             500                 505                 510        
 Leu Val Ala Leu Phe Ile Pro Glu Tyr Ser Lys Ala Ser Gly Val Gln
         515                 520                 525            
 Lys His Ser Asn Ser Ser Ser Gly Ser Leu Thr Asn Thr Pro Glu Arg
     530                 535                 540                
 Gly Ser Asp Glu Asp Ile Glu Pro Leu Leu Gln Asp Ser Ser Ile Trp
 545                 550                 555                 560
 Glu Leu Ser Ser Phe Glu Glu Pro Gly Asn Gln Cys Thr Glu Leu
                 565                 570                 575



      <210> 1074
      <211> 663
      <212> PRT
      <213> Homo sapiens


      <400> 1074
 Met Lys Arg Thr Ser Cys Pro Ser Arg Pro Arg Thr Ala Leu Val Leu
   1               5                  10                  15    
 Thr Leu Asn Val Arg His Pro Asp Asn Pro Tyr Ser Gln Ala Asn Gln
              20                  25                  30        
 Ala Ser Trp Ser Ser Asn Trp Arg Leu Ser Lys Glu Pro Ser Ala Pro
          35                  40                  45            
 Pro Pro Asp Pro Gln Ala Ala Ala Gly Arg Arg Ala His Glu Gly Ala
      50                  55                  60                
 Gly Thr Ala Ala Ala Ser Ala Ala Ser Pro Ser Ser Arg Ser Ala Pro
  65                  70                  75                  80
 Ser Trp Arg Gly His Gly Arg Gly Met Ser Val Glu Pro Pro Pro Glu
                  85                  90                  95    
 Leu Glu Glu Lys Ala Ala Ser Glu Pro Glu Ala Gly Ala Met Pro Glu
             100                 105                 110        
 Lys Arg Ala Gly Ala Gln Ala Ala Gly Ser Thr Trp Leu Gln Gly Phe
         115                 120                 125            
 Gly Pro Pro Ser Val Tyr His Ala Ala Ile Val Ile Phe Leu Glu Phe
     130                 135                 140                
 Phe Ala Trp Gly Leu Leu Thr Thr Pro Met Leu Thr Val Leu His Glu
 145                 150                 155                 160
 Thr Phe Ser Gln His Thr Phe Leu Met Asn Gly Leu Ile Gln Gly Val
                 165                 170                 175    
 Lys Pro Leu Trp Pro Ser Asp Pro Pro Gly Leu Ala Thr Asn Asn Lys
             180                 185                 190        
 Tyr Ser Leu Ser His Arg Cys Ser Phe Trp Gly Leu Val Tyr Ser Val
         195                 200                 205            
 Gln Lys Asp Thr Leu Arg Lys Lys Lys Gly Leu Leu Ser Phe Leu Ser
     210                 215                 220                
 Ala Pro Leu Ile Gly Ala Leu Ser Asp Val Trp Gly Arg Lys Pro Phe
 225                 230                 235                 240
 Leu Leu Gly Thr Val Phe Phe Thr Cys Phe Pro Ile Pro Leu Met Arg
                 245                 250                 255    
 Ile Ser Pro Trp Trp Tyr Phe Ala Met Ile Ser Val Ser Gly Val Phe
             260                 265                 270        
 Ser Val Thr Phe Ser Val Ile Phe Ala Tyr Val Ala Asp Val Thr Gln
         275                 280                 285            
 Glu His Glu Arg Ser Thr Ala Tyr Gly Trp Val Ser Ala Thr Phe Ala
     290                 295                 300                
 Ala Ser Leu Val Ser Ser Pro Ala Ile Gly Ala Tyr Leu Ser Ala Ser
 305                 310                 315                 320
 Tyr Gly Asp Ser Leu Val Val Leu Val Ala Thr Val Val Ala Leu Leu
                 325                 330                 335    
 Asp Ile Cys Phe Ile Leu Val Ala Val Pro Glu Ser Leu Pro Glu Lys
             340                 345                 350        
 Met Arg Pro Val Ser Trp Gly Ala Gln Ile Ser Trp Lys Gln Ala Asp
         355                 360                 365            
 Pro Phe Ala Ile Lys Ile Met Lys Leu Met Phe Gln Asn Ile Gly Asn
     370                 375                 380                
 Ile Asn Val Tyr Trp His Phe Lys Cys Val Leu Ser Ala Tyr Ser Gln
 385                 390                 395                 400
 Ser Leu Lys Lys Val Gly Lys Asp Ser Thr Val Leu Leu Ile Cys Ile
                 405                 410                 415    
 Thr Val Phe Leu Ser Tyr Leu Pro Glu Ala Gly Gln Tyr Ser Ser Phe
             420                 425                 430        
 Phe Leu Tyr Leu Arg Gln Val Ile Gly Phe Gly Ser Val Lys Ile Ala
         435                 440                 445            
 Ala Phe Ile Ala Met Val Gly Ile Leu Ser Ile Val Ala Gln Thr Ala
     450                 455                 460                
 Phe Leu Ser Ile Leu Met Arg Ser Leu Gly Asn Lys Asn Thr Val Leu
 465                 470                 475                 480
 Leu Gly Leu Gly Phe Gln Met Leu Gln Leu Ala Trp Tyr Gly Phe Gly
                 485                 490                 495    
 Ser Gln Ala Trp Met Met Trp Ala Ala Gly Thr Val Ala Ala Met Ser
             500                 505                 510        
 Ser Ile Thr Phe Pro Ala Ile Ser Ala Leu Val Ser Arg Asn Ala Glu
         515                 520                 525            
 Ser Asp Gln Gln Gly Val Ala Gln Gly Ile Ile Thr Gly Ile Arg Gly
     530                 535                 540                
 Leu Cys Asn Gly Leu Gly Pro Ala Leu Tyr Gly Phe Ile Phe Tyr Met
 545                 550                 555                 560
 Phe His Val Glu Leu Thr Glu Leu Gly Pro Lys Leu Asn Ser Asn Asn
                 565                 570                 575    
 Val Pro Leu Gln Gly Ala Val Ile Pro Gly Pro Pro Phe Leu Phe Gly
             580                 585                 590        
 Ala Cys Ile Val Leu Met Ser Phe Leu Val Ala Leu Phe Ile Pro Glu
         595                 600                 605            
 Tyr Ser Lys Ala Ser Gly Val Gln Lys His Ser Asn Ser Ser Ser Gly
     610                 615                 620                
 Ser Leu Thr Asn Thr Pro Glu Arg Gly Ser Asp Glu Asp Ile Glu Pro
 625                 630                 635                 640
 Leu Leu Gln Asp Ser Ser Ile Trp Glu Leu Ser Ser Phe Glu Glu Pro
                 645                 650                 655    
 Gly Asn Gln Cys Thr Glu Leu
             660            



      <210> 1075
      <211> 739
      <212> PRT
      <213> Homo sapiens


      <400> 1075
 Met Asp Asp Lys Glu Pro Lys Arg Trp Pro Thr Leu Arg Asp Arg Leu
   1               5                  10                  15    
 Cys Ser Asp Gly Phe Leu Phe Pro Gln Tyr Pro Ile Lys Pro Tyr His
              20                  25                  30        
 Leu Lys Gly Ile His Arg Ala Val Phe Tyr Arg Asp Leu Glu Glu Leu
          35                  40                  45            
 Lys Phe Val Leu Leu Thr Arg Tyr Asp Ile Asn Lys Arg Asp Arg Lys
      50                  55                  60                
 Glu Arg Thr Ala Leu His Leu Ala Cys Ala Thr Gly Gln Pro Glu Met
  65                  70                  75                  80
 Val His Leu Leu Val Ser Arg Arg Cys Glu Leu Asn Leu Cys Asp Arg
                  85                  90                  95    
 Glu Asp Arg Thr Pro Leu Ile Lys Ala Val Gln Leu Arg Gln Glu Ala
             100                 105                 110        
 Cys Ala Thr Leu Leu Leu Gln Asn Gly Ala Asp Pro Asn Ile Thr Asp
         115                 120                 125            
 Val Phe Gly Arg Thr Ala Leu His Tyr Ala Val Tyr Asn Glu Asp Thr
     130                 135                 140                
 Ser Met Ile Glu Lys Leu Leu Ser His Gly Thr Asn Ile Glu Glu Cys
 145                 150                 155                 160
 Ser Lys Asn Glu Tyr Gln Pro Leu Leu Leu Ala Val Ser Arg Arg Lys
                 165                 170                 175    
 Val Lys Met Val Glu Phe Leu Leu Lys Lys Lys Ala Asn Val Asn Ala
             180                 185                 190        
 Ile Asp Tyr Leu Gly Arg Ser Ala Leu Ile Leu Ala Val Thr Leu Gly
         195                 200                 205            
 Glu Lys Asp Ile Val Ile Leu Leu Leu Gln His Asn Ile Asp Val Phe
     210                 215                 220                
 Ser Arg Asp Val Tyr Gly Lys Leu Ala Glu Asp Tyr Ala Lys Arg Arg
 225                 230                 235                 240
 Ser Ser Ala Ser Arg Asp Leu Gly Ser Val Asn His Asp Asp Ile Val
                 245                 250                 255    
 Gly Trp Met Leu Val Ser Pro Gln Lys Gln Arg Ala Glu Lys Ala Thr
             260                 265                 270        
 Ser Asp Asp Lys Asp Ser Val Ser Asn Ile Ala Thr Glu Ile Lys Glu
         275                 280                 285            
 Gly Pro Ile Ser Gly Thr Asp His Leu Ser Glu Glu Lys Asn Phe Lys
     290                 295                 300                
 Glu Ser Cys Leu Phe Asp Arg Asp Leu Arg Glu Gln Leu Thr Thr Ile
 305                 310                 315                 320
 Asp Lys Glu Thr Leu Gln Gly Ala Ala Lys Pro Asp Ala His Phe Arg
                 325                 330                 335    
 Thr Met Pro Cys Gly Gln Leu Leu His Phe Leu Gln Arg Asn Thr Ile
             340                 345                 350        
 Ile Ala Ala Val Ser Gly Val Ala Ile Leu Met Ala Ile Val Leu Leu
         355                 360                 365            
 Leu Leu Gly Leu Ala Ser Tyr Ile Arg Lys Lys Gln Pro Ser Leu Gln
     370                 375                 380                
 Tyr Trp Arg Ala Ala Pro Gly Gly Arg Lys Gly Ile Pro Leu Leu His
 385                 390                 395                 400
 Ser Asp Ala Gln Ser Leu Asp Met Arg Asp Asp Gly Gly Gly Ser Ser
                 405                 410                 415    
 Asn Gly Ala Phe Ala Phe Arg Pro Leu Leu Thr Phe Thr Thr Ala Tyr
             420                 425                 430        
 Lys Thr Ala Val Ala Cys Val Leu Leu Thr Val Gln Pro Asp Trp Thr
         435                 440                 445            
 Cys Ser Ala Pro Gly Glu Met Asp Arg Lys Pro Ile Pro Ala Arg Ser
     450                 455                 460                
 Glu Asp Trp Glu Ala Phe Leu Glu Glu Asn Thr Leu Asn Trp Arg Pro
 465                 470                 475                 480
 Glu Arg Gly Leu Gly Asn Arg Gln Pro Pro Phe Leu Ser Ser His Pro
                 485                 490                 495    
 Gly Asn Arg Leu Val Ser Asp Lys Pro Ala Cys Arg Ser Ser Ala Asp
             500                 505                 510        
 Thr Arg Pro Ser Gly Gln Ala Trp Pro Thr Val Gly Leu Arg Ala Ala
         515                 520                 525            
 Ala Gly Ala Phe Arg Glu Ile Gln Thr Gly Phe Val Ser Pro Asp Ser
     530                 535                 540                
 Ser Pro Arg Thr Gly Ser Pro Leu Ala Leu Gly Pro Glu Thr Pro Gln
 545                 550                 555                 560
 Val Ala Cys Leu Pro Gly His Pro Pro Val Arg Pro Gln Gly Ser Arg
                 565                 570                 575    
 Glu Asp Lys Glu Ser Asp Cys Ile His Thr Ala Arg His Ile Gln Val
             580                 585                 590        
 Leu Gln Lys Gly Leu Thr Lys Thr Leu Ile Ile Leu Thr Ser Ser Gly
         595                 600                 605            
 Trp Pro Arg Ala Leu Asp Ser Thr Val Pro Val Cys Ser Pro Gly Leu
     610                 615                 620                
 Gln His Pro Asp His Pro Val Leu Thr Thr Pro Cys Pro Thr Pro Arg
 625                 630                 635                 640
 Cys Gln Val Pro Pro Val Leu Arg Gly Ile Pro Thr His Pro Ser Gly
                 645                 650                 655    
 Leu Gln Thr Phe Val Gly Thr Trp Tyr Ile Glu His Leu Leu Cys Ala
             660                 665                 670        
 Met Leu Gly Leu Gly Cys Glu Cys Gly Ala Gly Ala Pro Trp Leu Leu
         675                 680                 685            
 Cys Cys Asp Leu Cys Ala Val Ile Gln Gly Leu Cys Val Trp Asn His
     690                 695                 700                
 Thr Ile Arg Ser Pro Trp Asn Leu Val Ser Phe Ile Gln Pro Glu Ala
 705                 710                 715                 720
 Phe Ala Met Arg Leu Arg Asn Cys Val Ser Pro Tyr Ala Val Pro Leu
                 725                 730                 735    
 Thr Ala Glu
            



      <210> 1076
      <211> 406
      <212> PRT
      <213> Homo sapiens


      <400> 1076
 Met Glu Ala Val Gly Ile Trp Arg Lys Glu Leu Leu Gln Pro Gln Thr
   1               5                  10                  15    
 Glu Gly Lys Ala Leu Arg Glu Gly Thr Asp Pro Val Arg Met His Phe
              20                  25                  30        
 Pro Ser Val Arg Gly Pro Pro Phe Leu Pro Val Ser Gly Lys Arg Arg
          35                  40                  45            
 Leu Val Lys Val Ser Arg Pro Arg Cys Leu Lys Leu Arg Thr Arg Gln
      50                  55                  60                
 Lys Cys Ser Ser Tyr Phe Lys Asn Phe Arg Tyr Cys Ser Tyr Ala Pro
  65                  70                  75                  80
 His Val Arg Ile Cys Met Pro Leu Thr Asp Gly Ile Ser Ser Phe Glu
                  85                  90                  95    
 Asp Leu Leu Ala Asn Asn Ile Leu Arg Ile Phe Val Trp Val Ile Ala
             100                 105                 110        
 Phe Ile Thr Cys Phe Gly Asn Leu Phe Val Ile Gly Met Arg Ser Phe
         115                 120                 125            
 Ile Lys Ala Glu Asn Thr Thr His Ala Met Ser Ile Lys Ile Leu Cys
     130                 135                 140                
 Cys Ala Asp Cys Leu Met Gly Val Tyr Leu Phe Phe Val Gly Ile Phe
 145                 150                 155                 160
 Asp Ile Lys Tyr Arg Gly Gln Tyr Gln Lys Tyr Ala Leu Leu Trp Met
                 165                 170                 175    
 Glu Ser Val Gln Cys Arg Leu Met Gly Phe Leu Ala Met Leu Ser Thr
             180                 185                 190        
 Glu Val Ser Val Leu Leu Leu Thr Tyr Leu Thr Leu Glu Lys Phe Leu
         195                 200                 205            
 Val Ile Val Phe Pro Phe Ser Asn Ile Arg Pro Gly Lys Arg Gln Thr
     210                 215                 220                
 Ser Val Ile Leu Ile Cys Ile Trp Met Ala Gly Phe Leu Ile Ala Val
 225                 230                 235                 240
 Ile Pro Phe Trp Asn Lys Asp Tyr Phe Gly Asn Phe Tyr Gly Lys Asn
                 245                 250                 255    
 Gly Val Cys Phe Pro Leu Tyr Tyr Asp Gln Thr Glu Asp Ile Gly Ser
             260                 265                 270        
 Lys Gly Tyr Ser Leu Gly Ile Phe Leu Gly Val Asn Leu Leu Ala Phe
         275                 280                 285            
 Leu Ile Ile Val Phe Ser Tyr Ile Thr Met Phe Cys Ser Ile Gln Lys
     290                 295                 300                
 Thr Ala Leu Gln Thr Thr Glu Val Arg Asn Cys Phe Gly Arg Glu Val
 305                 310                 315                 320
 Ala Val Ala Asn Arg Phe Phe Phe Ile Val Phe Ser Asp Ala Ile Cys
                 325                 330                 335    
 Trp Ile Pro Val Phe Val Val Lys Ile Leu Ser Leu Phe Arg Val Glu
             340                 345                 350        
 Ile Pro Gly Gln Ser Leu Leu Ser Phe Pro Ser Ile Ile His Arg Ala
         355                 360                 365            
 Phe Leu Arg Pro Ser Phe Asp Lys Ala Arg Val Phe Gln Arg Asn Ile
     370                 375                 380                
 Asn Leu Asn Tyr His Pro Cys Met Lys Ile Pro Leu Gln Glu Leu Arg
 385                 390                 395                 400
 Asn Pro Gly Glu Arg Leu
                 405    



      <210> 1077
      <211> 512
      <212> PRT
      <213> Homo sapiens


      <400> 1077
 Met Ala Gly Gly Met Ser Ala Glu Cys Pro Glu Pro Gly Pro Gly Gly
   1               5                  10                  15    
 Leu Gln Gly Gln Ser Pro Gly Pro Gly Arg Gln Cys Pro Pro Pro Ile
              20                  25                  30        
 Thr Pro Thr Ser Trp Ser Leu Pro Pro Trp Arg Ala Tyr Val Ala Ala
          35                  40                  45            
 Ala Val Leu Cys Tyr Ile Asn Leu Leu Asn Tyr Met Asn Trp Phe Ile
      50                  55                  60                
 Ile Ala Gly Val Leu Leu Asp Ile Gln Glu Val Phe Gln Ile Ser Asp
  65                  70                  75                  80
 Asn His Ala Gly Leu Leu Gln Thr Val Phe Val Ser Cys Leu Leu Leu
                  85                  90                  95    
 Ser Ala Pro Val Phe Gly Tyr Leu Gly Asp Arg His Ser Arg Lys Ala
             100                 105                 110        
 Thr Met Ser Phe Gly Ile Leu Leu Trp Ser Gly Ala Gly Leu Ser Ser
         115                 120                 125            
 Ser Phe Ile Ser Pro Arg Tyr Ser Trp Leu Phe Phe Leu Ser Arg Gly
     130                 135                 140                
 Ile Val Gly Thr Gly Ser Ala Ser Tyr Ser Thr Ile Ala Pro Thr Val
 145                 150                 155                 160
 Leu Gly Asp Leu Phe Val Arg Asp Gln Arg Thr Arg Val Leu Ala Val
                 165                 170                 175    
 Phe Tyr Ile Phe Ile Pro Val Gly Ser Gly Leu Gly Tyr Val Leu Gly
             180                 185                 190        
 Ser Ala Val Thr Met Leu Thr Gly Asn Trp Arg Trp Ala Leu Arg Val
         195                 200                 205            
 Met Pro Cys Leu Glu Ala Val Ala Leu Ile Leu Leu Ile Leu Leu Val
     210                 215                 220                
 Pro Asp Pro Pro Arg Gly Ala Ala Glu Thr Gln Gly Glu Gly Ala Val
 225                 230                 235                 240
 Gly Gly Phe Arg Ser Ser Trp Cys Glu Asp Val Arg Tyr Leu Gly Lys
                 245                 250                 255    
 Asn Trp Ser Phe Val Trp Ser Thr Leu Gly Val Thr Ala Met Ala Phe
             260                 265                 270        
 Val Thr Gly Ala Leu Gly Phe Trp Ala Pro Lys Phe Leu Leu Glu Ala
         275                 280                 285            
 Arg Val Val His Gly Leu Gln Pro Pro Cys Phe Gln Glu Pro Cys Ser
     290                 295                 300                
 Asn Pro Asp Ser Leu Ile Phe Gly Ala Leu Thr Ile Met Thr Gly Val
 305                 310                 315                 320
 Ile Gly Val Ile Leu Gly Ala Glu Ala Ala Arg Arg Tyr Lys Lys Val
                 325                 330                 335    
 Ile Pro Gly Ala Glu Pro Leu Ile Cys Ala Ser Ser Leu Leu Ala Thr
             340                 345                 350        
 Ala Pro Cys Leu Tyr Leu Ala Leu Val Leu Ala Pro Thr Thr Leu Leu
         355                 360                 365            
 Ala Ser Tyr Val Phe Leu Gly Leu Gly Glu Leu Leu Leu Ser Cys Asn
     370                 375                 380                
 Trp Ala Val Val Ala Asp Ile Leu Leu Ser Val Val Val Pro Arg Cys
 385                 390                 395                 400
 Arg Gly Thr Ala Glu Ala Leu Gln Ile Thr Val Gly His Ile Leu Gly
                 405                 410                 415    
 Asp Ala Gly Ser Pro Tyr Leu Thr Gly Leu Ile Ser Ser Val Leu Arg
             420                 425                 430        
 Ala Arg Arg Pro Asp Ser Tyr Leu Gln Arg Phe Arg Ser Leu Gln Gln
         435                 440                 445            
 Ser Phe Leu Cys Cys Ala Phe Val Ile Ala Leu Gly Gly Gly Cys Phe
     450                 455                 460                
 Leu Leu Thr Ala Leu Tyr Leu Glu Arg Asp Glu Thr Arg Ala Trp Gln
 465                 470                 475                 480
 Pro Val Thr Gly Thr Pro Asp Ser Asn Asp Val Asp Ser Asn Asp Leu
                 485                 490                 495    
 Glu Arg Gln Gly Leu Leu Ser Gly Ala Gly Ala Ser Thr Glu Glu Pro
             500                 505                 510        





      <210> 1078
      <211> 1149
      <212> PRT
      <213> Homo sapiens


      <400> 1078
 Met Thr Ser Leu Ala Gln Gln Leu Gln Arg Leu Ala Leu Pro Gln Ser
   1               5                  10                  15    
 Asp Ala Ser Leu Leu Ser Arg Asp Glu Val Ala Ser Leu Leu Phe Asp
              20                  25                  30        
 Pro Lys Glu Ala Ala Thr Ile Asp Arg Asp Thr Ala Phe Ala Ile Gly
          35                  40                  45            
 Cys Thr Gly Leu Glu Glu Leu Leu Gly Ile Asp Pro Ser Phe Glu Gln
      50                  55                  60                
 Phe Glu Ala Pro Leu Phe Ser Gln Leu Ala Lys Thr Leu Glu Arg Ser
  65                  70                  75                  80
 Val Gln Thr Lys Ala Gln Ser Gly Val Pro Leu Ala Lys Gly Thr Leu
                  85                  90                  95    
 Ile Thr His Cys Tyr Lys Asp Leu Gly Phe Met Asp Phe Ile Cys Ser
             100                 105                 110        
 Leu Val Thr Lys Ser Val Lys Val Phe Ala Glu Tyr Pro Gly Ser Ser
         115                 120                 125            
 Ala Gln Leu Arg Val Leu Leu Ala Phe Tyr Ala Ser Thr Ile Val Ser
     130                 135                 140                
 Ala Leu Val Ala Ala Glu Asp Val Ser Asp Asn Ile Ile Ala Lys Leu
 145                 150                 155                 160
 Phe Pro Tyr Ile Gln Lys Ile Ile Lys Thr Leu Thr Lys Ile Pro Ser
                 165                 170                 175    
 Leu Ile Lys Asp Gly Leu Ser Cys Leu Ile Val Leu Leu Gln Arg Gln
             180                 185                 190        
 Lys Pro Glu Ser Leu Gly Lys Lys Tyr Glu Val Leu Lys Ile Ala Ala
         195                 200                 205            
 Asp Ile Leu Ile Lys Glu Glu Ile Leu Ser Glu Asn Asp Gln Leu Ser
     210                 215                 220                
 Asn Gln Val Val Val Cys Leu Leu Pro Phe Met Val Ile Asn Asn Asp
 225                 230                 235                 240
 Asp Thr Glu Ser Ala Glu Met Lys Ile Ala Ile Tyr Leu Ser Lys Ser
                 245                 250                 255    
 Gly Ile Cys Ser Leu His Pro Leu Leu Arg Gly Trp Glu Glu Gly Asp
             260                 265                 270        
 Ile Trp Trp Asn Pro Glu Gln Leu Lys Glu Asp Ser Arg Asp Tyr Leu
         275                 280                 285            
 His Leu Leu Ile Gly Leu Phe Glu Met Met Leu Asn Gly Ala Asp Ala
     290                 295                 300                
 Val His Phe Arg Val Leu Met Lys Leu Phe Ile Lys Met Val Leu Ser
 305                 310                 315                 320
 Gln Leu Leu Pro Met Ala Glu Gln Leu Leu Glu Lys Ile Gln Lys Glu
                 325                 330                 335    
 Pro Thr Ala Val Leu Lys Asp Glu Ala Met Val Leu His Leu Thr Leu
             340                 345                 350        
 Gly Lys Tyr Asn Glu Phe Ser Val Ser Leu Leu Asn Glu Asp Pro Lys
         355                 360                 365            
 Ser Leu Asp Ile Phe Ile Lys Ala Val His Thr Thr Lys Glu Leu Tyr
     370                 375                 380                
 Ala Gly Met Pro Thr Ile Gln Ile Thr Ala Leu Glu Lys Leu Ile Arg
 385                 390                 395                 400
 Ile Tyr Ile Ser Asp Pro Ala Leu Gly Asn Asn Arg Cys Leu Leu Asn
                 405                 410                 415    
 Ile Cys Gln Lys Leu Ser Pro Asp Gly Gly Lys Ile Pro Lys Asp Ile
             420                 425                 430        
 Leu Asp Glu Glu Lys Phe Asn Val Glu Leu Ile Val Gln Cys Ile Arg
         435                 440                 445            
 Leu Ser Glu Met Pro Gln Thr His His His Ala Leu Leu Leu Leu Gly
     450                 455                 460                
 Thr Val Ala Gly Ile Phe Pro Asp Lys Val Leu His Asn Ile Met Ser
 465                 470                 475                 480
 Ile Phe Thr Phe Met Gly Ala Asn Val Met Arg Leu Asp Asp Thr Tyr
                 485                 490                 495    
 Ser Phe Gln Val Ile Asn Lys Thr Val Lys Met Val Ile Pro Ala Leu
             500                 505                 510        
 Ile Gln Ser Asp Ser Gly Asp Ser Ile Glu Val Ser Arg Asn Val Glu
         515                 520                 525            
 Glu Ile Val Val Lys Ile Ile Ser Val Phe Val Asp Ala Leu Pro His
     530                 535                 540                
 Val Pro Glu His Arg Arg Leu Pro Ile Leu Val Gln Leu Val Asp Thr
 545                 550                 555                 560
 Leu Gly Ala Glu Lys Phe Leu Trp Ile Leu Leu Ile Leu Leu Phe Glu
                 565                 570                 575    
 Gln Tyr Val Thr Lys Thr Val Leu Ala Ala Ala Tyr Gly Glu Lys Asp
             580                 585                 590        
 Ala Ile Leu Glu Ala Asp Thr Glu Phe Trp Phe Ser Val Cys Cys Glu
         595                 600                 605            
 Phe Ser Val Gln His Gln Ile Gln Ser Leu Met Asn Ile Leu Gln Tyr
     610                 615                 620                
 Leu Leu Lys Leu Pro Glu Glu Lys Glu Ala Lys Glu Lys Gln Lys Arg
 625                 630                 635                 640
 Met Gln Val Ile Leu Ser Thr Ser Ser Glu Gly Phe Leu Lys Leu Leu
                 645                 650                 655    
 Glu Thr Val Leu Gly Tyr Ile Ser Ala Val Ala Gln Ser Met Glu Arg
             660                 665                 670        
 Asn Ala Asp Lys Leu Thr Val Lys Phe Trp Arg Ala Leu Leu Ser Lys
         675                 680                 685            
 Ala Tyr Asp Leu Leu Asp Lys Val Thr Arg Phe Leu Lys Leu Val Pro
     690                 695                 700                
 Asp Leu Leu Ala Ile Val Gln Arg Lys Lys Lys Glu Gly Glu Glu Glu
 705                 710                 715                 720
 Gln Ala Ile Asn Arg Gln Thr Ala Leu Tyr Thr Leu Lys Leu Leu Cys
                 725                 730                 735    
 Lys Asn Phe Gly Ala Glu Asn Pro Asp Pro Phe Val Pro Val Leu Asn
             740                 745                 750        
 Thr Ala Val Lys Leu Ile Ala Pro Glu Arg Lys Glu Glu Lys Asn Val
         755                 760                 765            
 Leu Gly Ser Ala Leu Leu Cys Ile Ala Glu Val Thr Ser Thr Leu Glu
     770                 775                 780                
 Ala Leu Ala Ile Pro Gln Leu Pro Ser Leu Met Pro Ser Leu Leu Thr
 785                 790                 795                 800
 Thr Met Lys Asn Thr Ser Glu Leu Val Ser Ser Glu Val Tyr Leu Leu
                 805                 810                 815    
 Ser Ala Leu Ala Ala Leu Gln Lys Val Val Glu Thr Leu Pro His Phe
             820                 825                 830        
 Ile Ser Pro Tyr Leu Glu Gly Ile Leu Ser Gln Asn His Met Gly Pro
         835                 840                 845            
 Phe Met Ser Ile Leu Gln Glu His Ile Gly Val Met Lys Lys Glu Glu
     850                 855                 860                
 Leu Thr Ser His Gln Ser Gln Leu Thr Ala Phe Phe Leu Glu Ala Leu
 865                 870                 875                 880
 Asp Phe Arg Ala Gln His Ser Glu Asn Asp Leu Glu Glu Val Gly Lys
                 885                 890                 895    
 Thr Glu Asn Cys Ile Ile Asp Cys Leu Val Ala Met Val Val Lys Leu
             900                 905                 910        
 Ser Glu Val Thr Phe Arg Pro Leu Phe Phe Lys Leu Phe Asp Trp Ala
         915                 920                 925            
 Lys Thr Glu Asp Ala Pro Lys Asp Arg Leu Leu Thr Phe Tyr Asn Leu
     930                 935                 940                
 Ala Asp Cys Ile Ala Glu Lys Leu Lys Gly Leu Phe Thr Leu Phe Ala
 945                 950                 955                 960
 Gly His Leu Val Lys Pro Phe Ala Asp Thr Leu Asn Gln Val Asn Ile
                 965                 970                 975    
 Ser Lys Thr Asp Glu Ala Phe Phe Asp Ser Glu Asn Asp Pro Glu Lys
             980                 985                 990        
 Cys Cys Leu Leu Leu Gln Phe Ile Leu Asn Cys Leu Tyr Lys Ile Phe
         995                1000                1005            
 Leu Phe Asp Thr Gln His Phe Ile Ser Lys Glu Arg Ala Glu Ala Leu
    1010                1015                1020                
 Met Met Pro Leu Val Asp Gln Leu Glu Asn Arg Leu Gly Gly Glu Glu
1025                1030                1035                1040
 Lys Phe Gln Glu Arg Val Thr Lys His Leu Ile Pro Cys Ile Ala Gln
                1045                1050                1055    
 Phe Ser Val Ala Met Ala Asp Asp Ser Leu Trp Lys Pro Leu Asn Tyr
            1060                1065                1070        
 Gln Ile Leu Leu Lys Thr Arg Asp Ser Ser Pro Lys Val Arg Phe Ala
        1075                1080                1085            
 Ala Leu Ile Thr Val Leu Ala Leu Ala Glu Lys Leu Lys Glu Asn Tyr
    1090                1095                1100                
 Ile Val Leu Leu Pro Glu Ser Ile Pro Phe Leu Ala Glu Leu Met Glu
1105                1110                1115                1120
 Asp Glu Cys Glu Glu Val Glu His Gln Cys Gln Lys Thr Ile Gln Gln
                1125                1130                1135    
 Leu Glu Thr Val Leu Gly Glu Pro Leu Gln Ser Tyr Phe
            1140                1145                



      <210> 1079
      <211> 499
      <212> PRT
      <213> Homo sapiens


      <400> 1079
 Met Glu Arg Ala Glu Glu Pro Val Val Tyr Gln Lys Leu Leu Pro Trp
   1               5                  10                  15    
 Glu Pro Ser Leu Glu Ser Glu Glu Glu Val Glu Glu Glu Glu Thr Ser
              20                  25                  30        
 Glu Ala Leu Val Leu Asn Pro Arg Arg His Gln Asp Ser Ser Arg Asn
          35                  40                  45            
 Lys Ala Gly Gly Leu Pro Gly Thr Trp Ala Arg Val Val Ala Ala Leu
      50                  55                  60                
 Leu Leu Leu Ala Val Gly Cys Ser Leu Ala Val Arg Gln Leu Gln Asn
  65                  70                  75                  80
 Gln Gly Arg Ser Thr Gly Ser Leu Gly Ser Val Ala Pro Pro Pro Gly
                  85                  90                  95    
 Gly His Ser His Gly Pro Gly Val Tyr His His Gly Ala Ile Ile Ser
             100                 105                 110        
 Pro Ala Pro Thr Cys Ser His Leu Gly Arg Glu Leu Leu Val Ala Gly
         115                 120                 125            
 Gly Asn Val Val Asp Ala Gly Val Gly Ala Ala Leu Cys Leu Ala Val
     130                 135                 140                
 Val His Pro His Ala Thr Gly Leu Gly Ala Met Phe Trp Gly Leu Phe
 145                 150                 155                 160
 His Asp Ser Ser Ser Gly Asn Ser Thr Ala Leu Thr Ser Gly Pro Ala
                 165                 170                 175    
 Gln Thr Leu Ala Pro Gly Leu Gly Leu Pro Ala Ala Leu Pro Thr Leu
             180                 185                 190        
 His Leu Leu His Ala Arg Phe Gly Arg Leu Pro Trp Pro Arg Leu Leu
         195                 200                 205            
 Val Gly Pro Thr Thr Leu Ala Gln Glu Gly Phe Leu Val Asp Thr Pro
     210                 215                 220                
 Leu Ala Arg Ala Leu Val Ala Arg Gly Thr Glu Gly Leu Cys Pro Leu
 225                 230                 235                 240
 Leu Cys His Ala Asp Gly Thr Pro Leu Gly Ala Gly Ala Arg Ala Thr
                 245                 250                 255    
 Asn Pro Gln Leu Ala Ala Val Leu Arg Ser Ala Ala Leu Ala Pro Thr
             260                 265                 270        
 Ser Asp Leu Ala Gly Asp Ala Leu Leu Ser Leu Leu Ala Gly Asp Leu
         275                 280                 285            
 Gly Val Glu Val Pro Ser Ala Val Pro Arg Pro Thr Leu Glu Pro Ala
     290                 295                 300                
 Glu Gln Leu Pro Val Pro Gln Gly Ile Leu Phe Thr Thr Pro Ser Pro
 305                 310                 315                 320
 Ser Ala Gly Pro Glu Leu Leu Ala Leu Leu Glu Ala Ala Leu Arg Ser
                 325                 330                 335    
 Gly Ala Pro Ile Pro Asp Pro Cys Pro Pro Phe Leu Gln Thr Ala Val
             340                 345                 350        
 Ser Pro Glu Ser Ser Ala Leu Ala Ala Val Asp Ser Ser Gly Ser Val
         355                 360                 365            
 Leu Leu Leu Thr Ser Ser Leu Asn Cys Ser Phe Gly Ser Ala His Leu
     370                 375                 380                
 Ser Pro Ser Thr Gly Val Leu Leu Ser Asn Leu Val Ala Lys Ser Thr
 385                 390                 395                 400
 Thr Ser Ala Trp Ala Cys Pro Leu Ile Leu Arg Gly Ser Leu Asp Asp
                 405                 410                 415    
 Thr Glu Ala Asp Val Leu Gly Leu Val Ala Ser Gly Thr Pro Asp Val
             420                 425                 430        
 Ala Arg Ala Met Thr His Thr Leu Leu Arg His Leu Ala Ala Arg Pro
         435                 440                 445            
 Pro Thr Gln Ala Gln His Gln His Gln Gly Gln Gln Glu Pro Thr Glu
     450                 455                 460                
 His Pro Ser Thr Cys Gly Gln Gly Thr Leu Leu Gln Val Ala Ala His
 465                 470                 475                 480
 Thr Glu His Ala His Val Ser Ser Val Pro His Ala Cys Cys Pro Phe
                 485                 490                 495    
 Gln Gly Phe
            



      <210> 1080
      <211> 1552
      <212> PRT
      <213> Homo sapiens


      <400> 1080
 Met Gly Ser Leu Gln Gln Ala Leu Val Cys Phe Glu Lys Arg Leu Val
   1               5                  10                  15    
 Val Ala His Glu Leu Gly Glu Ala Phe Asn Lys Ala Gln Ala Tyr Gly
              20                  25                  30        
 Glu Leu Gly Ser Leu His Ser Gln Leu Gly Asn Tyr Glu Gln Ala Ile
          35                  40                  45            
 Ser Cys Leu Glu Arg Gln Leu Asn Ile Ala Arg Asp Met Lys Asp Arg
      50                  55                  60                
 Ala Leu Glu Ser Asp Ala Ala Cys Gly Leu Gly Gly Val Tyr Gln Gln
  65                  70                  75                  80
 Met Gly Glu Tyr Asp Thr Ala Leu Gln Tyr His Gln Leu Asp Leu Gln
                  85                  90                  95    
 Ile Ala Glu Glu Thr Asn Asn Pro Thr Cys Gln Gly Arg Ala Tyr Gly
             100                 105                 110        
 Asn Leu Gly Leu Thr Tyr Glu Ser Leu Gly Thr Phe Glu Arg Ala Val
         115                 120                 125            
 Val Tyr Gln Glu Gln His Leu Ser Ile Ala Ala Gln Met Asn Asp Leu
     130                 135                 140                
 Ala Ala Lys Thr Val Ser Tyr Ser Ser Leu Gly Arg Thr His His Ala
 145                 150                 155                 160
 Leu Gln Asn Tyr Ser Gln Ala Val Met Tyr Leu Gln Glu Gly Leu Arg
                 165                 170                 175    
 Leu Ala Glu Gln Leu Gly Arg Arg Glu Asp Glu Ala Lys Ile Arg His
             180                 185                 190        
 Gly Leu Gly Leu Ser Leu Trp Ala Ser Gly Asn Leu Glu Glu Ala Gln
         195                 200                 205            
 His Gln Leu Tyr Arg Ala Ser Ala Leu Phe Glu Thr Ile Arg His Glu
     210                 215                 220                
 Ala Gln Leu Ser Thr Asp Tyr Lys Leu Ser Leu Phe Asp Leu Gln Thr
 225                 230                 235                 240
 Ser Ser Tyr Gln Ala Leu Gln Arg Val Leu Val Ser Leu Gly His His
                 245                 250                 255    
 Asp Glu Ala Leu Ala Val Ala Glu Arg Gly Arg Thr Arg Ala Phe Ala
             260                 265                 270        
 Asp Leu Leu Val Glu Arg Gln Thr Gly Gln Gln Asp Ser Asp Pro Tyr
         275                 280                 285            
 Ser Pro Val Thr Ile Asp Gln Ile Leu Glu Met Val Asn Gly Gln Arg
     290                 295                 300                
 Gly Leu Val Leu Tyr Tyr Ser Leu Ala Ala Gly Tyr Leu Tyr Ser Trp
 305                 310                 315                 320
 Leu Leu Ala Pro Gly Ala Gly Ile Val Lys Phe His Glu His Tyr Leu
                 325                 330                 335    
 Gly Glu Asn Thr Val Glu Asn Ser Ser Asp Phe Gln Ala Ser Ser Ser
             340                 345                 350        
 Val Thr Leu Pro Thr Ala Thr Gly Ser Ala Leu Glu Gln His Ile Ala
         355                 360                 365            
 Ser Val Arg Glu Ala Leu Gly Val Glu Ser His Tyr Ser Arg Ala Cys
     370                 375                 380                
 Ala Ser Ser Glu Thr Glu Ser Glu Ala Gly Asp Ile Met Asp Gln Gln
 385                 390                 395                 400
 Phe Glu Glu Met Asn Asn Lys Leu Asn Ser Val Thr Asp Pro Thr Gly
                 405                 410                 415    
 Phe Leu Arg Met Val Arg Arg Asn Asn Leu Phe Asn Arg Ser Cys Gln
             420                 425                 430        
 Ser Met Thr Ser Leu Phe Ser Asn Thr Val Ser Pro Thr Gln Asp Gly
         435                 440                 445            
 Thr Ser Ser Leu Pro Arg Arg Gln Ser Ser Phe Ala Lys Pro Pro Leu
     450                 455                 460                
 Arg Ala Leu Tyr Asp Leu Leu Ile Ala Pro Met Glu Gly Gly Leu Met
 465                 470                 475                 480
 His Ser Ser Gly Pro Val Gly Arg His Arg Gln Leu Ile Leu Val Leu
                 485                 490                 495    
 Glu Gly Glu Leu Tyr Leu Ile Pro Phe Ala Leu Leu Lys Gly Ser Ser
             500                 505                 510        
 Ser Asn Glu Tyr Leu Tyr Glu Arg Phe Gly Leu Leu Ala Val Pro Ser
         515                 520                 525            
 Ile Arg Ser Leu Ser Val Gln Ser Lys Ser His Leu Arg Lys Asn Pro
     530                 535                 540                
 Pro Thr Tyr Ser Ser Ser Thr Ser Met Ala Ala Val Ile Gly Asn Pro
 545                 550                 555                 560
 Lys Leu Pro Ser Ala Val Met Asp Arg Trp Leu Trp Gly Pro Met Pro
                 565                 570                 575    
 Ser Ala Glu Glu Glu Ala Tyr Met Val Ser Glu Leu Leu Gly Cys Gln
             580                 585                 590        
 Pro Leu Val Gly Ser Val Ala Thr Lys Glu Arg Val Met Ser Ala Leu
         595                 600                 605            
 Thr Gln Ala Glu Cys Val His Phe Ala Thr His Ile Ser Trp Lys Leu
     610                 615                 620                
 Ser Ala Leu Val Leu Thr Pro Ser Met Asp Gly Asn Pro Ala Ser Ser
 625                 630                 635                 640
 Lys Ser Ser Phe Gly His Pro Tyr Thr Ile Pro Glu Ser Leu Arg Val
                 645                 650                 655    
 Gln Asp Asp Ala Ser Asp Gly Glu Ser Ile Ser Asp Cys Pro Pro Leu
             660                 665                 670        
 Gln Glu Leu Leu Leu Thr Ala Ala Asp Val Leu Asp Leu Gln Leu Pro
         675                 680                 685            
 Val Lys Leu Val Val Leu Gly Ser Ser Gln Glu Ser Asn Ser Lys Val
     690                 695                 700                
 Ala Ala Asp Gly Val Ile Ala Leu Thr Arg Ala Phe Leu Ala Ala Gly
 705                 710                 715                 720
 Ala Gln Cys Val Leu Val Ser Leu Trp Pro Val Pro Val Ala Ala Phe
                 725                 730                 735    
 Lys Met Phe Ile His Ala Phe Tyr Ser Ser Leu Leu Asn Gly Leu Lys
             740                 745                 750        
 Ala Ser Ala Ala Leu Gly Glu Ala Met Lys Val Val Gln Ser Ser Lys
         755                 760                 765            
 Ala Phe Ser His Pro Ser Asn Trp Ala Gly Phe Met Leu Ile Gly Ser
     770                 775                 780                
 Asp Val Lys Leu Asn Ser Pro Ser Ser Leu Ile Gly Gln Ala Leu Thr
 785                 790                 795                 800
 Glu Ile Leu Gln His Pro Glu Arg Ala Arg Asp Ala Leu Arg Val Leu
                 805                 810                 815    
 Leu His Leu Val Glu Lys Ser Leu Gln Arg Ile Gln Asn Gly Gln Arg
             820                 825                 830        
 Asn Ala Met Tyr Thr Ser Gln Gln Ser Val Glu Asn Lys Val Gly Gly
         835                 840                 845            
 Ile Pro Gly Trp Gln Ala Leu Leu Thr Ala Val Gly Phe Arg Leu Asp
     850                 855                 860                
 Pro Pro Thr Ser Gly Leu Pro Ala Ala Val Phe Phe Pro Thr Ser Asp
 865                 870                 875                 880
 Pro Gly Asp Arg Leu Gln Gln Cys Ser Ser Thr Leu Gln Ser Leu Leu
                 885                 890                 895    
 Gly Leu Pro Asn Pro Ala Leu Gln Ala Leu Cys Lys Leu Ile Thr Ala
             900                 905                 910        
 Ser Glu Thr Gly Glu Gln Leu Ile Ser Arg Ala Val Lys Asn Met Val
         915                 920                 925            
 Gly Met Leu His Gln Val Leu Val Gln Leu Gln Ala Gly Glu Lys Glu
     930                 935                 940                
 Gln Asp Leu Ala Ser Ala Pro Ile Gln Val Ser Ile Ser Val Gln Leu
 945                 950                 955                 960
 Trp Arg Leu Pro Gly Cys His Glu Phe Leu Ala Ala Leu Gly Phe Asp
                 965                 970                 975    
 Leu Cys Glu Val Gly Gln Glu Glu Val Ile Leu Lys Thr Gly Lys Gln
             980                 985                 990        
 Ala Asn Arg Arg Thr Val His Phe Ala Leu Gln Ser Leu Leu Ser Leu
         995                1000                1005            
 Phe Asp Ser Thr Glu Leu Pro Lys Arg Leu Ser Leu Asp Ser Ser Ser
    1010                1015                1020                
 Ser Leu Glu Ser Leu Ala Ser Ala Gln Ser Val Ser Asn Ala Leu Pro
1025                1030                1035                1040
 Leu Gly Tyr Gln Gln Pro Pro Phe Ser Pro Thr Gly Ala Asp Ser Ile
                1045                1050                1055    
 Ala Ser Asp Ala Ile Ser Val Tyr Ser Leu Ser Ser Ile Ala Ser Ser
            1060                1065                1070        
 Met Ser Phe Val Ser Lys Pro Glu Gly Gly Ser Glu Gly Gly Gly Pro
        1075                1080                1085            
 Gly Gly Arg Gln Asp His Asp Arg Ser Lys Asn Ala Tyr Leu Gln Arg
    1090                1095                1100                
 Ser Thr Leu Pro Arg Ser Gln Leu Pro Pro Gln Thr Arg Pro Ala Gly
1105                1110                1115                1120
 Asn Lys Asp Glu Glu Glu Tyr Glu Gly Phe Ser Ile Ile Ser Asn Glu
                1125                1130                1135    
 Pro Leu Ala Thr Tyr Gln Glu Asn Arg Asn Thr Cys Phe Ser Pro Asp
            1140                1145                1150        
 His Lys Gln Pro Gln Pro Gly Thr Ala Gly Gly Met Arg Val Ser Val
        1155                1160                1165            
 Ser Ser Lys Gly Ser Ile Ser Thr Pro Asn Ser Pro Val Lys Met Thr
    1170                1175                1180                
 Leu Ile Pro Ser Pro Asn Ser Pro Phe Gln Lys Val Gly Lys Leu Ala
1185                1190                1195                1200
 Ser Ser Asp Thr Gly Glu Ser Asp Gln Ser Ser Thr Glu Thr Asp Ser
                1205                1210                1215    
 Thr Val Lys Ser Gln Glu Glu Ser Asn Pro Lys Leu Asp Pro Gln Glu
            1220                1225                1230        
 Leu Ala Gln Lys Ile Leu Glu Glu Thr Gln Ser His Leu Ile Ala Val
        1235                1240                1245            
 Glu Arg Leu Gln Arg Ser Gly Gly Gln Val Ser Lys Ser Asn Asn Pro
    1250                1255                1260                
 Glu Asp Gly Val Gln Ala Pro Ser Ser Thr Ala Val Phe Arg Ala Ser
1265                1270                1275                1280
 Glu Thr Ser Ala Phe Ser Arg Pro Val Leu Ser His Gln Lys Ser Gln
                1285                1290                1295    
 Pro Ser Pro Val Thr Val Lys Pro Lys Pro Pro Ala Arg Ser Ser Ser
            1300                1305                1310        
 Leu Pro Lys Val Ser Ser Gly Tyr Ser Ser Pro Thr Thr Ser Glu Met
        1315                1320                1325            
 Ser Ile Lys Asp Ser Pro Ser Gln His Ser Gly Arg Pro Ser Pro Gly
    1330                1335                1340                
 Cys Asp Ser Gln Thr Ser Gln Leu Asp Gln Pro Leu Phe Lys Leu Lys
1345                1350                1355                1360
 Tyr Pro Ser Ser Pro Tyr Ser Ala His Ile Ser Lys Ser Pro Arg Asn
                1365                1370                1375    
 Met Ser Pro Ser Ser Gly His Gln Ser Pro Ala Gly Ser Ala Pro Ser
            1380                1385                1390        
 Pro Ala Leu Ser Tyr Ser Ser Ala Gly Ser Ala Arg Ser Ser Pro Ala
        1395                1400                1405            
 Asp Ala Pro Asp Ile Asp Lys Leu Lys Met Ala Ala Ile Asp Glu Lys
    1410                1415                1420                
 Val Gln Ala Val His Asn Leu Lys Met Phe Trp Gln Ser Thr Pro Gln
1425                1430                1435                1440
 His Ser Thr Gly Pro Met Lys Ile Phe Arg Gly Ala Pro Gly Thr Met
                1445                1450                1455    
 Thr Ser Lys Arg Asp Val Leu Ser Leu Leu Asn Leu Ser Pro Arg His
            1460                1465                1470        
 Asn Lys Lys Glu Glu Gly Val Asp Lys Leu Glu Leu Lys Glu Leu Ser
        1475                1480                1485            
 Leu Gln Gln His Asp Gly Ala Pro Pro Lys Ala Pro Pro Asn Gly His
    1490                1495                1500                
 Trp Arg Thr Glu Thr Thr Ser Leu Gly Ser Leu Pro Leu Pro Ala Gly
1505                1510                1515                1520
 Pro Pro Ala Thr Ala Pro Ala Arg Pro Leu Arg Leu Pro Ser Gly Asn
                1525                1530                1535    
 Gly Tyr Lys Phe Leu Ser Pro Gly Arg Phe Phe Pro Ser Ser Lys Cys
            1540                1545                1550        





      <210> 1081
      <211> 485
      <212> PRT
      <213> Homo sapiens


      <400> 1081
 Met Val Gly Glu Glu Lys Met Ser Leu Arg Asn Arg Leu Ser Lys Ser
   1               5                  10                  15    
 Arg Glu Asn Pro Glu Glu Asp Glu Asp Gln Arg Ile Pro Ala Lys Glu
              20                  25                  30        
 Ser Leu Glu Thr Pro Ser Asn Gly Arg Ile Asp Ile Lys Gln Leu Ile
          35                  40                  45            
 Ala Lys Lys Ile Lys Leu Thr Ala Glu Ala Glu Ala Ile Asn Ser Ser
      50                  55                  60                
 Ser Pro Ile Asn Val Glu Ser Glu Ser Arg Ser Arg Phe Pro Val Lys
  65                  70                  75                  80
 Glu Val Glu Ile Thr Thr Arg Lys Lys Ile Met Lys Ser Phe Gln Glu
                  85                  90                  95    
 Leu Lys Pro Phe Phe Met Lys Glu Val Gly Ser His Phe Asp Asp Phe
             100                 105                 110        
 Val Thr Asn Leu Ile Glu Lys Ser Ala Ser Leu Asp Asn Gly Gly Cys
         115                 120                 125            
 Ala Leu Thr Thr Phe Ser Val Leu Glu Gly Glu Lys Asn Asn His Arg
     130                 135                 140                
 Ala Lys Asp Leu Arg Ala Pro Pro Glu Gln Gly Lys Ile Phe Ile Ala
 145                 150                 155                 160
 Arg Arg Ser Leu Leu Asp Thr Leu Val Val Asp Tyr Ile Asp Glu Gly
                 165                 170                 175    
 Arg Leu Val Leu Glu Phe Ser Leu Leu Ser Tyr Ala Phe Gly Lys Phe
             180                 185                 190        
 Pro Thr Val Val Trp Thr Trp Trp Ile Met Phe Leu Ser Thr Phe Ser
         195                 200                 205            
 Val Pro Tyr Phe Leu Phe Gln His Trp Ala Thr Gly Tyr Ser Lys Ser
     210                 215                 220                
 Ser His Pro Leu Ile Arg Ser Leu Phe His Gly Phe Leu Phe Met Ile
 225                 230                 235                 240
 Phe Gln Ile Gly Val Leu Gly Phe Gly Pro Thr Tyr Val Val Leu Ala
                 245                 250                 255    
 Tyr Thr Leu Pro Pro Ala Ser Arg Phe Ile Ile Ile Phe Glu Gln Ile
             260                 265                 270        
 Arg Phe Val Met Lys Ala His Ser Phe Val Arg Glu Asn Val Pro Arg
         275                 280                 285            
 Val Leu Asn Ser Ala Lys Glu Lys Ser Ser Thr Val Pro Ile Pro Thr
     290                 295                 300                
 Val Asn Gln Tyr Leu Tyr Phe Leu Phe Ala Pro Thr Leu Ile Tyr Arg
 305                 310                 315                 320
 Asp Ser Tyr Pro Arg Asn Pro Thr Val Arg Trp Gly Tyr Val Ala Met
                 325                 330                 335    
 Lys Phe Ala Gln Asp Trp Trp Asn Ser Thr Ser Tyr Ser Asn Tyr Tyr
             340                 345                 350        
 Arg Thr Trp Asn Val Val Val His Asp Trp Leu Tyr Tyr Tyr Ala Tyr
         355                 360                 365            
 Lys Asp Phe Leu Trp Phe Phe Ser Lys Arg Phe Lys Ser Ala Ala Met
     370                 375                 380                
 Leu Ala Val Phe Ala Val Ser Ala Val Val His Glu Tyr Ala Leu Ala
 385                 390                 395                 400
 Val Cys Leu Ser Phe Phe Tyr Pro Val Leu Phe Val Leu Phe Met Phe
                 405                 410                 415    
 Phe Gly Met Ala Phe Asn Phe Ile Val Asn Asp Ser Arg Lys Lys Pro
             420                 425                 430        
 Ile Trp Asn Val Leu Met Trp Thr Ser Leu Phe Leu Gly Asn Gly Val
         435                 440                 445            
 Leu Leu Cys Phe Tyr Ser Gln Glu Trp Tyr Ala Arg Gln His Cys Pro
     450                 455                 460                
 Leu Lys Asn Pro Thr Phe Leu Asp Tyr Val Arg Pro Arg Ser Trp Thr
 465                 470                 475                 480
 Cys Arg Tyr Val Phe
                 485



      <210> 1082
      <211> 1335
      <212> PRT
      <213> Homo sapiens


      <400> 1082
 Met Glu Ser Glu Met Leu Gln Ser Pro Leu Leu Gly Leu Gly Glu Glu
   1               5                  10                  15    
 Asp Glu Ala Asp Leu Thr Asp Trp Asn Leu Pro Leu Ala Phe Met Lys
              20                  25                  30        
 Lys Arg His Cys Glu Lys Ile Glu Gly Ser Lys Ser Leu Ala Gln Ser
          35                  40                  45            
 Trp Arg Met Lys Asp Arg Met Lys Thr Val Ser Val Ala Leu Val Leu
      50                  55                  60                
 Cys Leu Asn Val Gly Val Asp Pro Pro Asp Val Val Lys Thr Thr Pro
  65                  70                  75                  80
 Cys Ala Arg Leu Glu Cys Trp Ile Asp Pro Leu Ser Met Gly Pro Gln
                  85                  90                  95    
 Lys Ala Leu Glu Thr Ile Gly Ala Asn Leu Gln Lys Gln Tyr Glu Asn
             100                 105                 110        
 Trp Gln Pro Arg Ala Arg Tyr Lys Gln Ser Leu Asp Pro Thr Val Asp
         115                 120                 125            
 Glu Val Lys Lys Leu Cys Thr Ser Leu Arg Arg Asn Ala Lys Glu Glu
     130                 135                 140                
 Arg Val Leu Phe His Tyr Asn Gly His Gly Val Pro Arg Pro Thr Val
 145                 150                 155                 160
 Asn Gly Glu Val Trp Val Phe Asn Lys Asn Tyr Thr Gln Tyr Ile Pro
                 165                 170                 175    
 Leu Ser Ile Tyr Asp Leu Gln Thr Trp Met Gly Ser Pro Ser Ile Phe
             180                 185                 190        
 Val Tyr Asp Cys Ser Asn Ala Gly Leu Ile Val Lys Ser Phe Lys Gln
         195                 200                 205            
 Phe Ala Leu Gln Arg Glu Gln Glu Leu Glu Val Ala Ala Ile Asn Pro
     210                 215                 220                
 Asn His Pro Leu Ala Gln Met Pro Leu Pro Pro Ser Met Lys Asn Cys
 225                 230                 235                 240
 Ile Gln Leu Ala Ala Cys Glu Ala Thr Glu Leu Leu Pro Met Ile Pro
                 245                 250                 255    
 Asp Leu Pro Ala Asp Leu Phe Thr Ser Cys Leu Thr Thr Pro Ile Lys
             260                 265                 270        
 Ile Ala Leu Arg Trp Phe Cys Met Gln Lys Cys Val Ser Leu Val Pro
         275                 280                 285            
 Gly Val Thr Leu Asp Leu Ile Glu Lys Ile Pro Gly Arg Leu Asn Asp
     290                 295                 300                
 Arg Arg Thr Pro Leu Gly Glu Leu Asn Trp Ile Phe Thr Ala Ile Thr
 305                 310                 315                 320
 Asp Thr Ile Ala Trp Asn Val Leu Pro Arg Asp Leu Phe Gln Lys Leu
                 325                 330                 335    
 Phe Arg Gln Asp Leu Leu Val Ala Ser Leu Phe Arg Asn Phe Leu Leu
             340                 345                 350        
 Ala Glu Arg Ile Met Arg Ser Tyr Asn Cys Thr Pro Val Ser Ser Pro
         355                 360                 365            
 Arg Leu Pro Pro Thr Tyr Met His Ala Met Trp Gln Ala Trp Asp Leu
     370                 375                 380                
 Ala Val Asp Ile Cys Leu Ser Gln Leu Pro Thr Ile Ile Glu Glu Gly
 385                 390                 395                 400
 Thr Ala Phe Arg His Ser Pro Phe Phe Ala Glu Gln Leu Thr Ala Phe
                 405                 410                 415    
 Gln Val Trp Leu Thr Met Gly Val Glu Asn Arg Asn Pro Pro Glu Gln
             420                 425                 430        
 Leu Pro Ile Val Leu Gln Val Leu Leu Ser Gln Val His Arg Leu Arg
         435                 440                 445            
 Ala Leu Asp Leu Leu Gly Arg Phe Leu Asp Leu Gly Pro Trp Ala Val
     450                 455                 460                
 Ser Leu Ala Leu Ser Val Gly Ile Phe Pro Tyr Val Leu Lys Leu Leu
 465                 470                 475                 480
 Gln Ser Ser Ala Arg Glu Leu Arg Pro Leu Leu Val Phe Ile Trp Ala
                 485                 490                 495    
 Lys Ile Leu Ala Val Asp Ser Ser Cys Gln Ala Asp Leu Val Lys Asp
             500                 505                 510        
 Asn Gly His Lys Tyr Phe Leu Ser Val Leu Ala Asp Pro Tyr Met Pro
         515                 520                 525            
 Ala Glu His Arg Thr Met Thr Ala Phe Ile Leu Ala Val Ile Val Asn
     530                 535                 540                
 Ser Tyr His Thr Gly Gln Glu Ala Cys Leu Gln Gly Asn Leu Ile Ala
 545                 550                 555                 560
 Ile Cys Leu Glu Gln Leu Asn Asp Pro His Pro Leu Leu Arg Gln Trp
                 565                 570                 575    
 Val Ala Ile Cys Leu Gly Arg Ile Trp Gln Asn Phe Asp Ser Ala Arg
             580                 585                 590        
 Trp Cys Gly Val Arg Asp Ser Ala His Glu Lys Leu Tyr Ser Leu Leu
         595                 600                 605            
 Ser Asp Pro Ile Pro Glu Val Arg Cys Ala Ala Val Phe Ala Leu Gly
     610                 615                 620                
 Thr Phe Val Gly Asn Ser Ala Glu Arg Thr Asp His Ser Thr Thr Ile
 625                 630                 635                 640
 Asp His Asn Val Ala Met Met Leu Ala Gln Leu Val Ser Asp Gly Ser
                 645                 650                 655    
 Pro Met Val Arg Lys Glu Leu Val Val Ala Leu Ser His Leu Val Val
             660                 665                 670        
 Gln Tyr Glu Ser Asn Phe Cys Thr Val Ala Leu Gln Phe Ile Glu Glu
         675                 680                 685            
 Glu Lys Asn Tyr Ala Leu Pro Ser Pro Ala Thr Thr Glu Gly Gly Ser
     690                 695                 700                
 Leu Thr Pro Val Arg Asp Ser Pro Cys Thr Pro Arg Leu Arg Ser Val
 705                 710                 715                 720
 Ser Ser Tyr Gly Asn Ile Arg Ala Val Ala Thr Ala Arg Ser Leu Asn
                 725                 730                 735    
 Lys Ser Leu Gln Asn Leu Ser Leu Thr Glu Glu Ser Gly Gly Ala Val
             740                 745                 750        
 Ala Phe Ser Pro Gly Asn Leu Ser Thr Ser Ser Ser Ala Ser Ser Thr
         755                 760                 765            
 Leu Gly Ser Pro Glu Asn Glu Glu His Ile Leu Ser Phe Glu Thr Ile
     770                 775                 780                
 Asp Lys Met Arg Arg Ala Ser Ser Tyr Ser Ser Leu Asn Ser Leu Ile
 785                 790                 795                 800
 Gly Val Ser Phe Asn Ser Val Tyr Thr Gln Ile Trp Arg Val Leu Leu
                 805                 810                 815    
 His Leu Ala Ala Asp Pro Tyr Pro Glu Val Ser Asp Val Ala Met Lys
             820                 825                 830        
 Val Leu Asn Ser Ile Ala Tyr Lys Ala Thr Val Asn Ala Arg Pro Gln
         835                 840                 845            
 Arg Val Leu Asp Thr Ser Ser Leu Thr Gln Ser Ala Pro Ala Ser Pro
     850                 855                 860                
 Thr Asn Lys Gly Val His Ile His Gln Ala Gly Gly Ser Pro Pro Ala
 865                 870                 875                 880
 Ser Ser Thr Ser Ser Ser Ser Leu Thr Asn Asp Val Ala Lys Gln Pro
                 885                 890                 895    
 Val Ser Arg Asp Leu Pro Ser Gly Arg Pro Gly Thr Thr Gly Pro Ala
             900                 905                 910        
 Gly Ala Gln Tyr Thr Pro His Ser His Gln Phe Pro Arg Thr Arg Lys
         915                 920                 925            
 Met Phe Asp Lys Gly Pro Glu Gln Thr Ala Asp Asp Ala Asp Asp Ala
     930                 935                 940                
 Ala Gly His Lys Ser Phe Ile Ser Ala Thr Val Gln Thr Gly Phe Cys
 945                 950                 955                 960
 Asp Trp Ser Ala Arg Tyr Phe Ala Gln Pro Val Met Lys Ile Pro Glu
                 965                 970                 975    
 Glu His Asp Leu Glu Ser Gln Ile Arg Lys Glu Arg Glu Trp Arg Phe
             980                 985                 990        
 Leu Arg Asn Ser Arg Val Arg Arg Gln Ala Gln Gln Val Ile Gln Lys
         995                1000                1005            
 Gly Ile Thr Arg Leu Asp Asp Gln Ile Phe Leu Asn Arg Asn Pro Gly
    1010                1015                1020                
 Val Pro Ser Val Val Lys Phe His Pro Phe Thr Pro Cys Ile Ala Val
1025                1030                1035                1040
 Ala Asp Lys Asp Ser Ile Cys Phe Trp Asp Trp Glu Lys Gly Glu Lys
                1045                1050                1055    
 Leu Asp Tyr Phe His Asn Gly Asn Pro Arg Tyr Thr Arg Val Thr Ala
            1060                1065                1070        
 Met Glu Tyr Leu Asn Gly Gln Asp Cys Ser Leu Leu Leu Thr Ala Thr
        1075                1080                1085            
 Asp Asp Gly Ala Ile Arg Val Trp Lys Asn Phe Ala Asp Leu Glu Lys
    1090                1095                1100                
 Asn Pro Glu Met Val Thr Ala Trp Gln Gly Leu Ser Asp Met Leu Pro
1105                1110                1115                1120
 Thr Thr Arg Gly Ala Gly Met Val Val Asp Trp Glu Gln Glu Thr Gly
                1125                1130                1135    
 Leu Leu Met Ser Ser Gly Asp Val Arg Ile Val Arg Ile Trp Asp Thr
            1140                1145                1150        
 Asp Arg Glu Met Lys Val Gln Asp Ile Pro Thr Gly Ala Asp Ser Cys
        1155                1160                1165            
 Val Thr Ser Leu Ser Cys Asp Ser His Arg Ser Leu Ile Val Ala Gly
    1170                1175                1180                
 Leu Gly Asp Gly Ser Ile Arg Val Tyr Asp Arg Arg Met Ala Leu Ser
1185                1190                1195                1200
 Glu Cys Arg Val Met Thr Tyr Arg Glu His Thr Ala Trp Val Val Lys
                1205                1210                1215    
 Ala Ser Leu Gln Lys Arg Pro Asp Gly His Ile Val Ser Val Ser Val
            1220                1225                1230        
 Asn Gly Asp Val Arg Ile Phe Asp Pro Arg Met Pro Glu Ser Val Asn
        1235                1240                1245            
 Val Leu Gln Ile Val Lys Gly Leu Thr Ala Leu Asp Ile His Pro Gln
    1250                1255                1260                
 Ala Asp Leu Ile Ala Cys Gly Ser Val Asn Gln Phe Thr Ala Ile Tyr
1265                1270                1275                1280
 Asn Ser Ser Gly Glu Leu Ile Asn Asn Ile Lys Tyr Tyr Asp Gly Phe
                1285                1290                1295    
 Met Gly Gln Arg Val Gly Ala Ile Ser Cys Leu Ala Phe His Pro His
            1300                1305                1310        
 Trp Pro His Leu Ala Val Gly Ser Asn Asp Tyr Tyr Ile Ser Val Tyr
        1315                1320                1325            
 Ser Val Glu Lys Arg Val Arg
    1330                1335



      <210> 1083
      <211> 575
      <212> PRT
      <213> Homo sapiens


      <400> 1083
 Met Ile Tyr Leu Gln Ile Pro Tyr Leu Asn Ala Gly Gln Asn Leu Asp
   1               5                  10                  15    
 Ser Met Leu His Gly Thr Gly Met Lys Ser Asp Ser Asp Gln Lys Lys
              20                  25                  30        
 Ser Glu Asn Gly Val Thr Leu Ala Pro Glu Asp Thr Leu Pro Phe Leu
          35                  40                  45            
 Lys Cys Tyr Cys Ser Gly His Cys Pro Asp Asp Ala Ile Asn Asn Thr
      50                  55                  60                
 Cys Ile Thr Asn Gly His Cys Phe Ala Ile Ile Glu Glu Asp Asp Gln
  65                  70                  75                  80
 Gly Glu Thr Thr Leu Ala Ser Gly Cys Met Lys Tyr Glu Gly Ser Asp
                  85                  90                  95    
 Phe Gln Cys Lys Asp Ser Pro Lys Ala Gln Leu Arg Arg Thr Ile Glu
             100                 105                 110        
 Cys Cys Arg Thr Asn Leu Cys Asn Gln Tyr Leu Gln Pro Thr Leu Pro
         115                 120                 125            
 Pro Val Val Ile Gly Pro Phe Phe Asp Gly Ser Ile Arg Trp Leu Val
     130                 135                 140                
 Leu Leu Ile Ser Met Ala Val Cys Ile Ile Ala Met Ile Ile Phe Ser
 145                 150                 155                 160
 Ser Cys Phe Cys Tyr Lys Gly His Leu Leu Leu Arg Val Ile His Ile
                 165                 170                 175    
 Arg Gly Gln Leu Glu Ser Glu Gly Gly Val Pro Val Val Leu Arg His
             180                 185                 190        
 Tyr Cys Lys Ser Ile Ser Ser Arg Arg Arg Tyr Asn Arg Asp Leu Glu
         195                 200                 205            
 Gln Asp Glu Ala Phe Ile Pro Val Gly Glu Ser Leu Lys Asp Leu Ile
     210                 215                 220                
 Asp Gln Ser Gln Ser Ser Gly Ser Gly Ser Gly Leu Pro Leu Leu Val
 225                 230                 235                 240
 Gln Arg Thr Ile Ala Lys Gln Ile Gln Met Val Arg Gln Val Gly Lys
                 245                 250                 255    
 Gly Arg Tyr Gly Glu Val Trp Met Gly Lys Trp Arg Gly Glu Lys Val
             260                 265                 270        
 Ala Val Lys Val Phe Phe Thr Thr Glu Glu Ala Ser Trp Phe Arg Glu
         275                 280                 285            
 Thr Glu Ile Tyr Gln Thr Val Leu Met Arg His Glu Asn Ile Leu Gly
     290                 295                 300                
 Phe Ile Ala Ala Asp Ile Lys Gly Thr Gly Ser Trp Thr Gln Leu Tyr
 305                 310                 315                 320
 Leu Ile Thr Asp Tyr His Glu Asn Gly Ser Leu Tyr Asp Phe Leu Lys
                 325                 330                 335    
 Cys Ala Thr Leu Asp Thr Arg Ala Leu Leu Lys Leu Ala Tyr Ser Ala
             340                 345                 350        
 Ala Cys Gly Leu Cys His Leu His Thr Glu Ile Tyr Gly Thr Gln Gly
         355                 360                 365            
 Lys Pro Ala Ile Ala His Arg Asp Leu Lys Ser Lys Asn Ile Leu Ile
     370                 375                 380                
 Lys Lys Asn Gly Ser Cys Cys Ile Ala Asp Leu Gly Leu Ala Val Lys
 385                 390                 395                 400
 Phe Asn Ser Asp Thr Asn Glu Val Asp Val Pro Leu Asn Thr Arg Val
                 405                 410                 415    
 Gly Thr Lys Arg Tyr Met Ala Pro Glu Val Leu Asp Glu Ser Leu Asn
             420                 425                 430        
 Lys Asn His Phe Gln Pro Tyr Ile Met Ala Asp Ile Tyr Ser Phe Gly
         435                 440                 445            
 Leu Ile Ile Trp Glu Met Ala Arg Arg Cys Ile Thr Gly Gly Ile Val
     450                 455                 460                
 Glu Glu Tyr Gln Leu Pro Tyr Tyr Asn Met Val Pro Ser Asp Pro Ser
 465                 470                 475                 480
 Tyr Glu Asp Met Arg Glu Val Val Cys Val Lys Arg Leu Arg Pro Ile
                 485                 490                 495    
 Val Ser Asn Arg Trp Asn Ser Asp Glu Val Ser Gly Thr Gln Ser Pro
             500                 505                 510        
 Glu Glu Val Ile Arg Lys Cys His Gln Ile Tyr Ser Leu Leu Thr Glu
         515                 520                 525            
 His Leu Phe Thr Phe Gln Cys Leu Arg Ala Val Leu Lys Leu Met Ser
     530                 535                 540                
 Glu Cys Trp Ala His Asn Pro Ala Ser Arg Leu Thr Ala Leu Arg Ile
 545                 550                 555                 560
 Lys Lys Thr Leu Ala Lys Met Val Glu Ser Gln Asp Val Lys Ile
                 565                 570                 575



      <210> 1084
      <211> 637
      <212> PRT
      <213> Homo sapiens


      <400> 1084
 Met Ile Tyr Leu Gln Ile Pro Tyr Leu Asn Ala Gly Gln Asn Leu Asp
   1               5                  10                  15    
 Ser Met Leu His Gly Thr Gly Met Lys Ser Asp Ser Asp Gln Lys Lys
              20                  25                  30        
 Ser Glu Asn Gly Val Thr Leu Ala Pro Glu Asp Thr Leu Pro Phe Leu
          35                  40                  45            
 Lys Cys Tyr Cys Ser Gly His Cys Pro Asp Asp Ala Ile Asn Asn Thr
      50                  55                  60                
 Cys Ile Thr Asn Gly His Cys Phe Ala Ile Ile Glu Glu Asp Asp Gln
  65                  70                  75                  80
 Gly Glu Thr Thr Leu Ala Ser Gly Cys Met Lys Tyr Glu Gly Ser Asp
                  85                  90                  95    
 Phe Gln Cys Lys Asp Ser Pro Lys Ala Gln Leu Arg Arg Thr Ile Glu
             100                 105                 110        
 Cys Cys Arg Thr Asn Leu Cys Asn Gln Tyr Leu Gln Pro Thr Leu Pro
         115                 120                 125            
 Pro Val Val Ile Gly Pro Phe Phe Asp Gly Ser Ile Arg Trp Leu Val
     130                 135                 140                
 Leu Leu Ile Ser Met Ala Val Cys Ile Ile Ala Met Ile Ile Phe Ser
 145                 150                 155                 160
 Ser Cys Phe Cys Tyr Lys Gly His Leu Leu Leu Arg Val Ile His Ile
                 165                 170                 175    
 Arg Gly Gln Leu Glu Ser Glu Gly Gly Val Pro Val Val Leu Arg Ile
             180                 185                 190        
 Leu Cys Pro Gln Gly Glu Arg Lys Val Ser Ser Ser Pro Leu Pro Gln
         195                 200                 205            
 His Gln Arg Ile Leu Ala Trp Ser Glu His Arg Glu His Phe Leu Tyr
     210                 215                 220                
 Ile Pro Lys Arg Gln Arg Asp Phe Ala Ala Ser Pro Pro Ser Lys Val
 225                 230                 235                 240
 Met Asp Leu Cys Leu Cys Ser Gly Ala Gly Gly Arg Gly His Tyr Cys
                 245                 250                 255    
 Lys Ser Ile Ser Ser Arg Arg Arg Tyr Asn Arg Asp Leu Glu Gln Asp
             260                 265                 270        
 Glu Ala Phe Ile Pro Val Gly Glu Ser Leu Lys Asp Leu Ile Asp Gln
         275                 280                 285            
 Ser Gln Ser Ser Gly Ser Gly Ser Gly Leu Pro Leu Leu Val Gln Arg
     290                 295                 300                
 Thr Ile Ala Lys Gln Ile Gln Met Val Arg Gln Val Gly Lys Gly Arg
 305                 310                 315                 320
 Tyr Gly Glu Val Trp Met Gly Lys Trp Arg Gly Glu Lys Val Ala Val
                 325                 330                 335    
 Lys Val Phe Phe Thr Thr Glu Glu Ala Ser Trp Phe Arg Glu Thr Glu
             340                 345                 350        
 Ile Tyr Gln Thr Val Leu Met Arg His Glu Asn Ile Leu Gly Phe Ile
         355                 360                 365            
 Ala Ala Asp Ile Lys Gly Thr Gly Ser Trp Thr Gln Leu Tyr Leu Ile
     370                 375                 380                
 Thr Asp Tyr His Glu Asn Gly Ser Leu Tyr Asp Phe Leu Lys Cys Ala
 385                 390                 395                 400
 Thr Leu Asp Thr Arg Ala Leu Leu Lys Leu Ala Tyr Ser Ala Ala Cys
                 405                 410                 415    
 Gly Leu Cys His Leu His Thr Glu Ile Tyr Gly Thr Gln Gly Lys Pro
             420                 425                 430        
 Ala Ile Ala His Arg Asp Leu Lys Ser Lys Asn Ile Leu Ile Lys Lys
         435                 440                 445            
 Asn Gly Ser Cys Cys Ile Ala Asp Leu Gly Leu Ala Val Lys Phe Asn
     450                 455                 460                
 Ser Asp Thr Asn Glu Val Asp Val Pro Leu Asn Thr Arg Val Gly Thr
 465                 470                 475                 480
 Lys Arg Tyr Met Ala Pro Glu Val Leu Asp Glu Ser Leu Asn Lys Asn
                 485                 490                 495    
 His Phe Gln Pro Tyr Ile Met Ala Asp Ile Tyr Ser Phe Gly Leu Ile
             500                 505                 510        
 Ile Trp Glu Met Ala Arg Arg Cys Ile Thr Gly Gly Ile Val Glu Glu
         515                 520                 525            
 Tyr Gln Leu Pro Tyr Tyr Asn Met Val Pro Ser Asp Pro Ser Tyr Glu
     530                 535                 540                
 Asp Met Arg Glu Val Val Cys Val Lys Arg Leu Arg Pro Ile Val Ser
 545                 550                 555                 560
 Asn Arg Trp Asn Ser Asp Glu Val Ser Gly Thr Gln Ser Pro Glu Glu
                 565                 570                 575    
 Val Ile Arg Lys Cys His Gln Ile Tyr Ser Leu Leu Thr Glu His Leu
             580                 585                 590        
 Phe Thr Phe Gln Cys Leu Arg Ala Val Leu Lys Leu Met Ser Glu Cys
         595                 600                 605            
 Trp Ala His Asn Pro Ala Ser Arg Leu Thr Ala Leu Arg Ile Lys Lys
     610                 615                 620                
 Thr Leu Ala Lys Met Val Glu Ser Gln Asp Val Lys Ile
 625                 630                 635        



      <210> 1085
      <211> 533
      <212> PRT
      <213> Homo sapiens


      <400> 1085
 Met Tyr Gln Pro Asn Thr Leu Asp Pro Ile Phe Gly Met Met Phe Glu
   1               5                  10                  15    
 Leu Thr Cys Asn Ile Pro Leu Glu Lys Asp Leu Glu Ile Gln Leu Tyr
              20                  25                  30        
 Asp Phe Asp Leu Phe Ser Pro Asp Asp Lys Ile Gly Thr Thr Val Ile
          35                  40                  45            
 Asp Leu Glu Asn Arg Leu Leu Ser Gly Phe Gly Ala His Cys Gly Leu
      50                  55                  60                
 Ser Lys Ser Tyr Cys Gln Ser Gly Pro Phe Arg Trp Arg Asp Gln Met
  65                  70                  75                  80
 Pro Pro Ser Tyr Leu Leu Glu Arg Tyr Ala Lys Arg Lys Gly Leu Pro
                  85                  90                  95    
 Pro Pro Leu Phe Ser Pro Glu Glu Asp Ala Val Phe Tyr Asn Gly Lys
             100                 105                 110        
 Lys Phe Lys Leu Gln Ser Phe Glu Pro Lys Thr Pro Thr Val His Gly
         115                 120                 125            
 Leu Gly Pro Lys Lys Glu Arg Leu Ala Leu Tyr Leu Leu His Thr Gln
     130                 135                 140                
 Gly Leu Val Pro Glu His Val Glu Thr Arg Thr Leu Tyr Ser His Ser
 145                 150                 155                 160
 Gln Pro Gly Ile Asp Gln Gly Lys Val Gln Met Trp Val Asp Ile Phe
                 165                 170                 175    
 Pro Lys Lys Leu Gly Pro Pro Gly Pro Gln Val Asn Ile Asn Pro Arg
             180                 185                 190        
 Lys Pro Lys Arg Tyr Glu Leu Arg Cys Ile Ile Trp Lys Thr Ala Asn
         195                 200                 205            
 Val Asp Leu Val Asp Asp Asn Leu Ser Arg Glu Lys Thr Ser Asp Ile
     210                 215                 220                
 Tyr Ile Lys Gly Trp Leu Tyr Gly Leu Glu Lys Asp Met Gln Lys Thr
 225                 230                 235                 240
 Asp Ile His Tyr His Ser Leu Thr Gly Glu Ala Asp Phe Asn Trp Arg
                 245                 250                 255    
 Phe Ile Phe Thr Met Asp Tyr Leu Ala Ala Glu Arg Thr Cys Val Gln
             260                 265                 270        
 Ser Gln Lys Asp Tyr Ile Trp Ser Leu Asp Ala Thr Ser Met Lys Phe
         275                 280                 285            
 Pro Ala Arg Leu Ile Ile Gln Val Trp Asp Asn Asp Ile Phe Ser Pro
     290                 295                 300                
 Asp Asp Phe Leu Gly Val Leu Glu Leu Asp Leu Ser Asp Met Pro Leu
 305                 310                 315                 320
 Pro Ala Arg His Ala Lys Gln Cys Ser Ile Arg Met Met Asp Ala Asp
                 325                 330                 335    
 Pro Lys Trp Pro Tyr Phe Ile Gln Tyr Lys His Phe Ser Leu Phe Lys
             340                 345                 350        
 Lys Lys Thr Val Thr Gly Trp Trp Pro Cys Gln Val Leu Asp Gly Gly
         355                 360                 365            
 Lys Trp Arg Leu Ser Gly Lys Val Lys Met Ser Leu Glu Ile Leu Ser
     370                 375                 380                
 Glu Lys Glu Ala Leu Ile Lys Pro Ala Gly Arg Gly Gln Ser Glu Pro
 385                 390                 395                 400
 Asn Gln Tyr Pro Thr Leu His Pro Pro Leu Arg Thr Asn Thr Ser Phe
                 405                 410                 415    
 Thr Trp Leu Arg Ser Pro Val Gln Asn Phe Cys Tyr Ile Phe Trp Lys
             420                 425                 430        
 Arg Tyr Arg Phe Lys Leu Ile Ala Phe Met Val Ile Ser Ile Ile Ala
         435                 440                 445            
 Leu Met Leu Phe Asn Phe Ile Tyr Ser Ala Pro His Tyr Leu Ala Met
     450                 455                 460                
 Ser Trp Ile Lys Pro Gln Leu Gln Leu Tyr Pro Pro Ile Lys Ile Phe
 465                 470                 475                 480
 Asn Ile Ile Asn Ser Leu Asn Thr Ser Asn Ala Ser Ser Ser Ile Leu
                 485                 490                 495    
 Pro Thr Gln Asp Pro Asn Leu Lys Pro Thr Ile Asp His Glu Trp Lys
             500                 505                 510        
 Leu His Pro Gly Pro Thr Asn His Leu Ser Asp Ile Phe Pro Glu Leu
         515                 520                 525            
 Pro Ala Pro Gly Asp
     530            



      <210> 1086
      <211> 802
      <212> PRT
      <213> Homo sapiens


      <400> 1086
 Met Lys Lys Ala Ser Ser Pro Gln Leu Leu Val Glu Phe Gly Glu Glu
   1               5                  10                  15    
 Ser Leu Arg Thr Glu Pro Ile Arg Asp Phe Gln Thr Asn Pro Asn Phe
              20                  25                  30        
 Pro Glu Ser Glu Ser Val Leu Val Leu Thr Val Leu Met Pro Thr Glu
          35                  40                  45            
 Glu Ala Tyr Ala Leu Pro Leu Val Val Lys Val Val Asp Asn Trp Ala
      50                  55                  60                
 Phe Gly Gln Gln Thr Val Thr Gly Gln Ala Asn Ile Asp Phe Leu Gln
  65                  70                  75                  80
 Pro Tyr Phe Cys Asp Pro Trp Ala Gln Asp Tyr Met His Pro Lys Leu
                  85                  90                  95    
 Pro Thr Leu Ser Glu Lys Lys His Gln Asp Phe Leu Gly Tyr Leu Tyr
             100                 105                 110        
 Arg Lys Phe Trp Phe Lys Ser Ser Lys Ala Glu Asp Glu Tyr Glu His
         115                 120                 125            
 Glu Val Asp Trp Trp Ser Lys Leu Phe Trp Ala Thr Asp Glu His Lys
     130                 135                 140                
 Ser Leu Lys Tyr Lys Tyr Lys Asp Tyr His Thr Leu Lys Val Tyr Glu
 145                 150                 155                 160
 Cys Glu Leu Glu Ala Val Pro Ala Phe Gln Gly Leu Gln Asp Phe Cys
                 165                 170                 175    
 Gln Thr Phe Lys Leu Tyr Gln Glu Gln Pro Lys Leu Asp Ser Pro Val
             180                 185                 190        
 Val Gly Glu Phe Lys Gly Leu Phe Arg Ile Tyr Pro Phe Pro Glu Asn
         195                 200                 205            
 Pro Glu Ala Pro Lys Pro Pro Leu Gln Phe Leu Val Trp Pro Glu Arg
     210                 215                 220                
 Glu Asp Phe Pro Gln Pro Cys Leu Val Arg Val Tyr Met Val Arg Ala
 225                 230                 235                 240
 Ile Asn Leu Gln Pro Gln Asp Tyr Asn Gly Leu Cys Asp Pro Tyr Val
                 245                 250                 255    
 Ile Leu Lys Leu Gly Lys Thr Glu Leu Gly Asn Arg Asp Met Tyr Gln
             260                 265                 270        
 Pro Asn Thr Leu Asp Pro Ile Phe Gly Met Met Phe Glu Leu Thr Cys
         275                 280                 285            
 Asn Ile Pro Leu Glu Lys Asp Leu Glu Ile Gln Leu Tyr Asp Phe Asp
     290                 295                 300                
 Leu Phe Ser Pro Asp Asp Lys Ile Gly Thr Thr Val Ile Asp Leu Glu
 305                 310                 315                 320
 Asn Arg Leu Leu Ser Gly Phe Gly Ala His Cys Gly Leu Ser Lys Ser
                 325                 330                 335    
 Tyr Cys Gln Ser Gly Pro Phe Arg Trp Arg Asp Gln Met Pro Pro Ser
             340                 345                 350        
 Tyr Leu Leu Glu Arg Tyr Ala Lys Arg Lys Gly Leu Pro Pro Pro Leu
         355                 360                 365            
 Phe Ser Pro Glu Glu Asp Ala Val Phe Tyr Asn Gly Lys Lys Phe Lys
     370                 375                 380                
 Leu Gln Ser Phe Glu Pro Lys Thr Pro Thr Val His Gly Leu Gly Pro
 385                 390                 395                 400
 Lys Lys Glu Arg Leu Ala Leu Tyr Leu Leu His Thr Gln Gly Leu Val
                 405                 410                 415    
 Pro Glu His Val Glu Thr Arg Thr Leu Tyr Ser His Ser Gln Pro Gly
             420                 425                 430        
 Ile Asp Gln Gly Lys Val Gln Met Trp Val Asp Ile Phe Pro Lys Lys
         435                 440                 445            
 Leu Gly Pro Pro Gly Pro Gln Val Asn Ile Asn Pro Arg Lys Pro Lys
     450                 455                 460                
 Arg Tyr Glu Leu Arg Cys Ile Ile Trp Lys Thr Ala Asn Val Asp Leu
 465                 470                 475                 480
 Val Asp Asp Asn Leu Ser Arg Glu Lys Thr Ser Asp Ile Tyr Ile Lys
                 485                 490                 495    
 Gly Trp Leu Tyr Gly Leu Glu Lys Asp Met Gln Lys Thr Asp Ile His
             500                 505                 510        
 Tyr His Ser Leu Thr Gly Glu Ala Asp Phe Asn Trp Arg Phe Ile Phe
         515                 520                 525            
 Thr Met Asp Tyr Leu Ala Ala Glu Arg Thr Cys Val Gln Ser Gln Lys
     530                 535                 540                
 Asp Tyr Ile Trp Ser Leu Asp Ala Thr Ser Met Lys Phe Pro Ala Arg
 545                 550                 555                 560
 Leu Ile Ile Gln Val Trp Asp Asn Asp Ile Phe Ser Pro Asp Asp Phe
                 565                 570                 575    
 Leu Gly Val Leu Glu Leu Asp Leu Ser Asp Met Pro Leu Pro Ala Arg
             580                 585                 590        
 His Ala Lys Gln Cys Ser Ile Arg Met Met Asp Ala Asp Pro Lys Trp
         595                 600                 605            
 Pro Tyr Phe Ile Gln Tyr Lys His Phe Ser Leu Phe Lys Lys Lys Thr
     610                 615                 620                
 Val Thr Gly Trp Trp Pro Cys Gln Val Leu Asp Gly Gly Lys Trp Arg
 625                 630                 635                 640
 Leu Ser Gly Lys Val Lys Met Ser Leu Glu Ile Leu Ser Glu Lys Glu
                 645                 650                 655    
 Ala Leu Ile Lys Pro Ala Gly Arg Gly Gln Ser Glu Pro Asn Gln Tyr
             660                 665                 670        
 Pro Thr Leu His Pro Pro Leu Arg Thr Asn Thr Ser Phe Thr Trp Leu
         675                 680                 685            
 Arg Ser Pro Val Gln Asn Phe Cys Tyr Ile Phe Trp Lys Arg Tyr Arg
     690                 695                 700                
 Phe Lys Leu Ile Ala Phe Met Val Ile Ser Ile Ile Ala Leu Met Leu
 705                 710                 715                 720
 Phe Asn Phe Ile Tyr Ser Ala Pro His Tyr Leu Ala Met Ser Trp Ile
                 725                 730                 735    
 Lys Pro Gln Leu Gln Leu Tyr Pro Pro Ile Lys Ile Phe Asn Ile Ile
             740                 745                 750        
 Asn Ser Leu Asn Thr Ser Asn Ala Ser Ser Ser Ile Leu Pro Thr Gln
         755                 760                 765            
 Asp Pro Asn Leu Lys Pro Thr Ile Asp His Glu Trp Lys Leu His Pro
     770                 775                 780                
 Gly Pro Thr Asn His Leu Ser Asp Ile Phe Pro Glu Leu Pro Ala Pro
 785                 790                 795                 800
 Gly Asp
        



      <210> 1087
      <211> 1207
      <212> PRT
      <213> Homo sapiens


      <400> 1087
 Met Leu Lys Phe Ala Ala Arg Cys Leu Thr Gly Tyr Ser Gln Ser Arg
   1               5                  10                  15    
 Ala Ser Leu Pro Thr Thr Leu Ser Phe Lys Asp Thr Phe Ile Ile Lys
              20                  25                  30        
 Gly Gly Val Glu Asp Leu Glu Pro Asp Ala Ser Cys Trp Pro Leu Arg
          35                  40                  45            
 Val Leu Ser Leu Pro Trp Gly Ala Val Leu Gly Gly Glu Arg Gly His
      50                  55                  60                
 Ala Asp Lys Ser Leu Arg Phe Pro Gly Trp Arg His Gln Gln Glu Ser
  65                  70                  75                  80
 Gly Gly Gly Arg Gly Pro Thr Met Pro Ala Thr Pro Asn Phe Leu Ala
                  85                  90                  95    
 Asn Pro Ser Ser Ser Ser Arg Trp Ile Pro Leu Gln Pro Met Pro Val
             100                 105                 110        
 Ala Trp Ala Phe Val Gln Lys Thr Ser Ala Leu Leu Trp Leu Leu Leu
         115                 120                 125            
 Leu Gly Thr Ser Leu Ser Pro Ala Trp Gly Gln Ala Lys Ile Pro Leu
     130                 135                 140                
 Glu Thr Val Lys Leu Trp Ala Asp Thr Phe Gly Gly Asp Leu Tyr Asn
 145                 150                 155                 160
 Thr Val Thr Lys Tyr Ser Gly Ser Leu Leu Leu Gln Lys Lys Tyr Lys
                 165                 170                 175    
 Asp Val Glu Ser Ser Leu Lys Ile Glu Glu Val Asp Gly Leu Glu Leu
             180                 185                 190        
 Val Arg Lys Phe Ser Glu Asp Met Glu Asn Met Leu Arg Arg Lys Val
         195                 200                 205            
 Glu Ala Val Gln Asn Leu Val Glu Ala Ala Glu Glu Ala Asp Leu Asn
     210                 215                 220                
 His Glu Phe Asn Glu Ser Leu Val Phe Asp Tyr Tyr Asn Ser Val Leu
 225                 230                 235                 240
 Ile Asn Glu Arg Asp Glu Lys Gly Asn Phe Val Glu Leu Gly Ala Glu
                 245                 250                 255    
 Phe Leu Leu Glu Ser Asn Ala His Phe Ser Asn Leu Pro Val Asn Thr
             260                 265                 270        
 Ser Ile Ser Ser Val Gln Leu Pro Thr Asn Val Tyr Asn Lys Asp Pro
         275                 280                 285            
 Asp Ile Leu Asn Gly Val Tyr Met Ser Glu Ala Leu Asn Ala Val Phe
     290                 295                 300                
 Val Glu Asn Phe Gln Arg Asp Pro Thr Leu Thr Trp Gln Tyr Phe Gly
 305                 310                 315                 320
 Ser Ala Thr Gly Phe Phe Arg Ile Tyr Pro Gly Ile Lys Trp Thr Pro
                 325                 330                 335    
 Asp Glu Asn Gly Val Ile Thr Phe Asp Cys Arg Asn Arg Gly Trp Tyr
             340                 345                 350        
 Ile Gln Ala Ala Thr Ser Pro Lys Asp Ile Val Ile Leu Val Asp Val
         355                 360                 365            
 Ser Gly Ser Met Lys Gly Leu Arg Met Thr Ile Ala Lys His Thr Ile
     370                 375                 380                
 Thr Thr Ile Leu Asp Thr Leu Gly Glu Asn Asp Phe Ile Asn Ile Ile
 385                 390                 395                 400
 Ala Tyr Asn Asp Tyr Val His Tyr Ile Glu Pro Cys Phe Lys Gly Ile
                 405                 410                 415    
 Leu Val Gln Ala Asp Arg Asp Asn Arg Glu His Phe Lys Leu Leu Val
             420                 425                 430        
 Glu Glu Leu Met Val Lys Gly Val Gly Val Val Asp Gln Ala Leu Arg
         435                 440                 445            
 Glu Ala Phe Gln Ile Leu Lys Gln Phe Gln Glu Ala Lys Gln Gly Ser
     450                 455                 460                
 Leu Cys Asn Gln Ala Ile Met Leu Ile Ser Asp Gly Ala Val Glu Asp
 465                 470                 475                 480
 Tyr Glu Pro Val Phe Glu Lys Tyr Asn Trp Pro Asp Cys Lys Val Arg
                 485                 490                 495    
 Val Phe Thr Tyr Leu Ile Gly Arg Glu Val Ser Phe Ala Asp Arg Met
             500                 505                 510        
 Lys Trp Ile Ala Cys Asn Asn Lys Gly Tyr Tyr Thr Gln Ile Ser Thr
         515                 520                 525            
 Leu Ala Asp Thr Gln Glu Asn Val Met Glu Tyr Leu His Val Leu Ser
     530                 535                 540                
 Arg Pro Met Val Ile Asn His Asp His Asp Ile Ile Trp Thr Glu Ala
 545                 550                 555                 560
 Tyr Met Asp Ser Lys Leu Leu Ser Ser Gln Ala Gln Ser Leu Thr Leu
                 565                 570                 575    
 Leu Thr Thr Val Ala Met Pro Val Phe Ser Lys Lys Asn Glu Thr Arg
             580                 585                 590        
 Ser His Gly Ile Leu Leu Gly Val Val Gly Ser Asp Val Ala Leu Arg
         595                 600                 605            
 Glu Leu Met Lys Leu Ala Pro Arg Tyr Lys Leu Gly Val His Gly Tyr
     610                 615                 620                
 Ala Phe Leu Asn Thr Asn Asn Gly Tyr Ile Leu Ser His Pro Asp Leu
 625                 630                 635                 640
 Arg Pro Leu Tyr Arg Glu Gly Lys Lys Leu Lys Pro Lys Pro Asn Tyr
                 645                 650                 655    
 Asn Ser Val Asp Leu Ser Glu Val Glu Trp Glu Asp Gln Ala Glu Ser
             660                 665                 670        
 Leu Arg Thr Ala Met Ile Asn Arg Glu Thr Gly Thr Leu Ser Met Asp
         675                 680                 685            
 Val Lys Val Pro Met Asp Lys Gly Lys Arg Val Leu Phe Leu Thr Asn
     690                 695                 700                
 Asp Tyr Phe Phe Thr Asp Ile Ser Asp Thr Pro Phe Ser Leu Gly Val
 705                 710                 715                 720
 Val Leu Ser Arg Gly His Gly Glu Tyr Ile Leu Leu Gly Asn Thr Ser
                 725                 730                 735    
 Val Glu Glu Gly Leu His Asp Leu Leu His Pro Asp Leu Ala Leu Ala
             740                 745                 750        
 Gly Asp Trp Ile Tyr Cys Ile Thr Asp Ile Asp Pro Asp His Arg Lys
         755                 760                 765            
 Leu Ser Gln Leu Glu Ala Met Ile Arg Phe Leu Thr Arg Lys Asp Pro
     770                 775                 780                
 Asp Leu Glu Cys Asp Glu Glu Leu Val Arg Glu Val Leu Phe Asp Ala
 785                 790                 795                 800
 Val Val Thr Ala Pro Met Glu Ala Tyr Trp Thr Ala Leu Ala Leu Asn
                 805                 810                 815    
 Met Ser Glu Glu Ser Glu His Val Val Asp Met Ala Phe Leu Gly Thr
             820                 825                 830        
 Arg Ala Gly Leu Leu Arg Ser Ser Leu Phe Val Gly Ser Glu Lys Val
         835                 840                 845            
 Ser Asp Arg Lys Phe Leu Thr Pro Glu Asp Glu Ala Ser Val Phe Thr
     850                 855                 860                
 Leu Asp Arg Phe Pro Leu Trp Tyr Arg Gln Ala Ser Glu His Pro Ala
 865                 870                 875                 880
 Gly Ser Phe Val Phe Asn Leu Arg Trp Ala Glu Gly Pro Glu Ser Ala
                 885                 890                 895    
 Gly Glu Pro Met Val Val Thr Ala Ser Thr Ala Val Ala Val Thr Val
             900                 905                 910        
 Asp Lys Arg Thr Ala Ile Ala Ala Ala Ala Gly Val Gln Met Lys Leu
         915                 920                 925            
 Glu Phe Leu Gln Arg Lys Phe Trp Ala Ala Thr Arg Gln Cys Ser Thr
     930                 935                 940                
 Val Asp Gly Pro Cys Thr Gln Ser Cys Glu Asp Ser Asp Leu Asp Cys
 945                 950                 955                 960
 Phe Val Ile Asp Asn Asn Gly Phe Ile Leu Ile Ser Lys Arg Ser Arg
                 965                 970                 975    
 Glu Thr Gly Arg Phe Leu Gly Glu Val Asp Gly Ala Val Leu Thr Gln
             980                 985                 990        
 Leu Leu Ser Met Gly Val Phe Ser Gln Val Thr Met Tyr Asp Tyr Gln
         995                1000                1005            
 Ala Met Cys Lys Pro Ser Ser His His His Ser Ala Ala Gln Pro Leu
    1010                1015                1020                
 Val Ser Pro Ile Ser Ala Phe Leu Thr Ala Thr Arg Trp Leu Leu Gln
1025                1030                1035                1040
 Glu Leu Val Leu Phe Leu Leu Glu Trp Ser Val Trp Gly Ser Trp Tyr
                1045                1050                1055    
 Asp Arg Gly Ala Glu Ala Lys Ser Val Phe His His Ser His Lys His
            1060                1065                1070        
 Lys Lys Gln Asp Pro Leu Gln Pro Cys Asp Thr Glu Tyr Pro Val Phe
        1075                1080                1085            
 Val Tyr Gln Pro Ala Ile Arg Glu Ala Asn Gly Ile Val Glu Cys Gly
    1090                1095                1100                
 Pro Cys Gln Lys Val Phe Val Val Gln Gln Ile Pro Asn Ser Asn Leu
1105                1110                1115                1120
 Leu Leu Leu Val Thr Asp Pro Thr Cys Asp Cys Ser Ile Phe Pro Pro
                1125                1130                1135    
 Val Leu Gln Glu Ala Thr Glu Val Lys Tyr Asn Ala Ser Val Lys Cys
            1140                1145                1150        
 Asp Arg Met Arg Ser Gln Lys Leu Arg Arg Arg Pro Asp Ser Cys His
        1155                1160                1165            
 Ala Phe His Pro Glu Glu Asn Ala Gln Asp Cys Gly Gly Ala Ser Asp
    1170                1175                1180                
 Thr Ser Ala Ser Pro Pro Leu Leu Leu Leu Pro Val Cys Ala Trp Gly
1185                1190                1195                1200
 Leu Leu Pro Gln Leu Leu Arg
                1205        



      <210> 1088
      <211> 675
      <212> PRT
      <213> Homo sapiens


      <400> 1088
 Met Gly Ile Tyr Gly Ser Val Pro Tyr Leu Leu Ala His Lys Leu Gly
   1               5                  10                  15    
 Arg Thr Ile Gly Ile Phe Trp Leu Asn Ala Ser Glu Thr Leu Val Glu
              20                  25                  30        
 Ile Asn Thr Glu Pro Ala Val Glu Tyr Thr Leu Thr Gln Met Gly Pro
          35                  40                  45            
 Val Ala Ala Lys Gln Lys Val Arg Ser Arg Thr His Val His Trp Met
      50                  55                  60                
 Ser Glu Ser Gly Ile Ile Asp Val Phe Leu Leu Thr Gly Pro Thr Pro
  65                  70                  75                  80
 Ser Asp Val Phe Lys Gln Tyr Ser His Leu Thr Gly Ile Cys Thr Lys
                  85                  90                  95    
 Lys Cys Gln Phe Leu Val Leu Leu His Ile Gln Cys Pro Met Cys His
             100                 105                 110        
 His Gly Thr Gln Ala Met Pro Pro Leu Phe Ser Leu Gly Tyr His Gln
         115                 120                 125            
 Cys Arg Trp Asn Tyr Glu Asp Glu Gln Asp Val Lys Ala Val Asp Ala
     130                 135                 140                
 Gly Phe Asp Glu His Asp Ile Pro Tyr Asp Ala Met Trp Leu Asp Ile
 145                 150                 155                 160
 Glu His Thr Glu Gly Lys Arg Tyr Phe Thr Trp Asp Lys Asn Arg Phe
                 165                 170                 175    
 Pro Asn Pro Lys Arg Met Gln Glu Leu Leu Arg Ser Lys Lys Arg Lys
             180                 185                 190        
 Leu Val Val Ile Ser Asp Pro His Ile Lys Ile Asp Pro Asp Tyr Ser
         195                 200                 205            
 Val Tyr Val Lys Ala Lys Asp Gln Gly Phe Phe Val Lys Asn Gln Glu
     210                 215                 220                
 Gly Glu Asp Phe Glu Gly Val Cys Trp Pro Gly Leu Ser Ser Tyr Leu
 225                 230                 235                 240
 Asp Phe Thr Asn Pro Lys Val Arg Glu Trp Tyr Ser Ser Leu Phe Ala
                 245                 250                 255    
 Phe Pro Val Tyr Gln Gly Ser Thr Asp Ile Leu Phe Leu Trp Asn Asp
             260                 265                 270        
 Met Asn Glu Pro Ser Val Phe Arg Gly Pro Glu Gln Thr Met Gln Lys
         275                 280                 285            
 Asn Ala Ile His His Gly Asn Trp Glu His Arg Glu Leu His Asn Ile
     290                 295                 300                
 Tyr Gly Phe Tyr His Gln Met Ala Thr Ala Glu Gly Leu Ile Lys Arg
 305                 310                 315                 320
 Ser Lys Gly Lys Glu Arg Pro Phe Val Leu Thr Arg Ser Phe Phe Ala
                 325                 330                 335    
 Gly Ser Gln Lys Tyr Gly Ala Val Trp Thr Gly Asp Asn Thr Ala Glu
             340                 345                 350        
 Trp Ser Asn Leu Lys Ile Ser Ile Pro Met Leu Leu Thr Leu Ser Ile
         355                 360                 365            
 Thr Gly Ile Ser Phe Cys Gly Ala Asp Ile Gly Gly Phe Ile Gly Asn
     370                 375                 380                
 Pro Glu Thr Glu Leu Leu Val Arg Trp Tyr Gln Ala Gly Ala Tyr Gln
 385                 390                 395                 400
 Pro Phe Phe Arg Gly His Ala Thr Met Asn Thr Lys Arg Arg Glu Pro
                 405                 410                 415    
 Trp Leu Phe Gly Glu Glu His Thr Arg Leu Ile Arg Glu Ala Ile Arg
             420                 425                 430        
 Glu Arg Tyr Gly Leu Leu Pro Tyr Trp Tyr Ser Leu Phe Tyr His Ala
         435                 440                 445            
 His Val Ala Ser Gln Pro Val Met Arg Pro Leu Trp Val Glu Phe Pro
     450                 455                 460                
 Asp Glu Leu Lys Thr Phe Asp Met Glu Asp Glu Tyr Met Leu Gly Ser
 465                 470                 475                 480
 Ala Leu Leu Val His Pro Val Thr Glu Pro Lys Ala Thr Thr Val Asp
                 485                 490                 495    
 Val Phe Leu Pro Gly Ser Asn Glu Val Trp Tyr Asp Tyr Lys Thr Phe
             500                 505                 510        
 Ala His Trp Glu Gly Gly Cys Thr Val Lys Ile Pro Val Ala Leu Asp
         515                 520                 525            
 Thr Ile Pro Val Phe Gln Arg Gly Gly Ser Val Ile Pro Ile Lys Thr
     530                 535                 540                
 Thr Val Gly Lys Ser Thr Gly Trp Met Thr Glu Ser Ser Tyr Gly Leu
 545                 550                 555                 560
 Arg Val Ala Leu Ser Thr Lys Gly Ser Ser Val Gly Glu Leu Tyr Leu
                 565                 570                 575    
 Asp Asp Gly His Ser Phe Gln Tyr Leu His Gln Lys Gln Phe Leu His
             580                 585                 590        
 Arg Lys Phe Ser Phe Cys Ser Ser Val Leu Ile Asn Ser Ser Ala Asp
         595                 600                 605            
 Gln Arg Gly His Tyr Pro Ser Lys Cys Val Val Glu Lys Ile Leu Val
     610                 615                 620                
 Leu Gly Phe Arg Lys Glu Pro Ser Ser Val Thr Thr His Ser Ser Asp
 625                 630                 635                 640
 Gly Lys Asp Gln Pro Val Ala Phe Thr Tyr Cys Ala Lys Thr Ser Ile
                 645                 650                 655    
 Leu Ser Leu Glu Lys Leu Ser Leu Asn Ile Ala Thr Asp Trp Glu Val
             660                 665                 670        
 Arg Ile Ile
         675



      <210> 1089
      <211> 83
      <212> PRT
      <213> Homo sapiens


      <400> 1089
 Met Asp Ala Val Lys His Pro Thr Val Gln Ala Gln Pro Pro Thr Thr
   1               5                  10                  15    
 Lys Ser Cys Leu Ala Gln Ile Ser Thr Val Leu Gln Cys Arg Asn Leu
              20                  25                  30        
 Ile Val Gly Phe Leu Leu Met Gln Asn Ser His Lys Asn Leu Ser Leu
          35                  40                  45            
 Phe Leu Ser Leu Ile Ile Cys Leu Ile His Pro Lys Arg Lys Gly Glu
      50                  55                  60                
 Gly His Gln Phe Thr Tyr Thr Pro Val Ala Pro Ser Pro Leu Lys Ile
  65                  70                  75                  80
 Phe Ile Lys
            



      <210> 1090
      <211> 843
      <212> PRT
      <213> Homo sapiens


      <400> 1090
 Met Cys Gly Leu Leu Ala Asp Pro Gly Val Pro Leu Leu Val Ala Met
   1               5                  10                  15    
 Ala Pro Ala Gly Ala Ala Arg Ala Gly Val Gly Leu Gly Val Ser Gly
              20                  25                  30        
 Ile Pro Gly Pro Val Leu His Pro Gly Leu Asp Leu Asp Pro Arg Ala
          35                  40                  45            
 Leu Gln Arg Pro Ser Val Gly Phe Gln Ala Glu Glu Ile Leu Arg His
      50                  55                  60                
 Pro Gly Ala Ala Gly Ser Cys Tyr Leu Ala Pro Ser Val Ser Thr Ala
  65                  70                  75                  80
 Arg Cys Cys Leu Ser Cys Leu Ser Val Phe Leu Leu Asn Ser Asp Ser
                  85                  90                  95    
 Gln Pro Ala Glu His Pro His Thr His Ser Gly Val Gly Ala Gln Leu
             100                 105                 110        
 Pro Val Tyr Leu Val Ser Leu Val Gln Pro Gly Ala Leu Pro Arg Pro
         115                 120                 125            
 Pro Gln Ala Gly Val Asp Met Ala Glu Thr Leu Glu Phe Asn Asp Val
     130                 135                 140                
 Tyr Gln Glu Val Lys Gly Ser Met Asn Asp Gly Arg Leu Arg Leu Ser
 145                 150                 155                 160
 Arg Gln Gly Ile Ile Phe Lys Asn Ser Lys Thr Gly Lys Val Asp Asn
                 165                 170                 175    
 Ile Gln Ala Gly Glu Leu Thr Glu Gly Ile Trp Arg Arg Val Ala Leu
             180                 185                 190        
 Gly His Gly Leu Lys Leu Leu Thr Lys Asn Gly His Val Tyr Lys Tyr
         195                 200                 205            
 Asp Gly Phe Arg Glu Ser Glu Phe Glu Lys Leu Ser Asp Phe Phe Lys
     210                 215                 220                
 Thr His Tyr Arg Leu Glu Leu Met Glu Lys Asp Leu Cys Val Lys Gly
 225                 230                 235                 240
 Trp Asn Trp Gly Thr Val Lys Phe Gly Gly Gln Leu Leu Ser Phe Asp
                 245                 250                 255    
 Ile Gly Asp Gln Pro Val Phe Glu Ile Pro Leu Ser Asn Val Ser Gln
             260                 265                 270        
 Cys Thr Thr Gly Lys Asn Glu Val Thr Leu Glu Phe His Gln Asn Asp
         275                 280                 285            
 Asp Ala Glu Val Ser Leu Met Glu Val Arg Phe Tyr Val Pro Pro Thr
     290                 295                 300                
 Gln Glu Asp Gly Val Asp Pro Val Glu Ala Phe Ala Gln Asn Val Leu
 305                 310                 315                 320
 Ser Lys Ala Asp Val Ile Gln Ala Thr Gly Asp Ala Ile Cys Ile Phe
                 325                 330                 335    
 Arg Glu Leu Gln Cys Leu Thr Pro Arg Gly Arg Tyr Asp Ile Arg Ile
             340                 345                 350        
 Tyr Pro Thr Phe Leu His Leu His Gly Lys Thr Phe Asp Tyr Lys Ile
         355                 360                 365            
 Pro Tyr Thr Thr Val Leu Arg Leu Phe Leu Leu Pro His Lys Asp Gln
     370                 375                 380                
 Arg Gln Met Phe Phe Val Ile Ser Leu Asp Pro Pro Ile Lys Gln Gly
 385                 390                 395                 400
 Gln Thr Arg Tyr His Phe Leu Ile Leu Leu Phe Ser Lys Asp Glu Asp
                 405                 410                 415    
 Ile Ser Leu Thr Leu Asn Met Asn Glu Glu Glu Val Glu Lys Arg Phe
             420                 425                 430        
 Glu Gly Arg Leu Thr Lys Asn Met Ser Gly Ser Leu Tyr Glu Met Val
         435                 440                 445            
 Ser Arg Val Met Lys Ala Leu Val Asn Arg Lys Ile Thr Val Pro Gly
     450                 455                 460                
 Asn Phe Gln Gly His Ser Gly Ala Gln Cys Ile Thr Cys Ser Tyr Lys
 465                 470                 475                 480
 Ala Ser Ser Gly Leu Leu Tyr Pro Leu Glu Arg Gly Phe Ile Tyr Val
                 485                 490                 495    
 His Lys Pro Pro Val His Ile Arg Phe Asp Glu Ile Ser Phe Val Asn
             500                 505                 510        
 Phe Ala Arg Gly Thr Thr Thr Thr Arg Ser Phe Asp Phe Glu Ile Glu
         515                 520                 525            
 Thr Lys Gln Gly Thr Gln Tyr Thr Phe Ser Ser Ile Glu Arg Glu Glu
     530                 535                 540                
 Tyr Gly Lys Leu Phe Asp Phe Val Asn Ala Lys Lys Leu Asn Ile Lys
 545                 550                 555                 560
 Asn Arg Gly Leu Lys Glu Gly Met Asn Pro Ser Tyr Asp Glu Tyr Ala
                 565                 570                 575    
 Asp Ser Asp Glu Asp Gln His Asp Ala Tyr Leu Glu Arg Met Lys Glu
             580                 585                 590        
 Glu Gly Lys Ile Arg Glu Glu Asn Ala Asn Asp Ser Ser Asp Asp Ser
         595                 600                 605            
 Gly Glu Glu Thr Asp Glu Ser Phe Asn Pro Gly Glu Glu Glu Glu Asp
     610                 615                 620                
 Val Ala Glu Glu Phe Asp Ser Asn Ala Ser Ala Ser Ser Ser Ser Asn
 625                 630                 635                 640
 Glu Gly Asp Ser Asp Arg Asp Glu Lys Lys Arg Lys Gln Leu Lys Lys
                 645                 650                 655    
 Ala Lys Met Ala Lys Asp Arg Lys Ser Arg Lys Lys Pro Val Glu Val
             660                 665                 670        
 Lys Lys Gly Lys Asp Pro Asn Ala Pro Lys Arg Pro Met Ser Ala Tyr
         675                 680                 685            
 Met Leu Trp Leu Asn Ala Ser Arg Glu Lys Ile Lys Ser Asp His Pro
     690                 695                 700                
 Gly Ile Ser Ile Thr Asp Leu Ser Lys Lys Ala Gly Glu Ile Trp Lys
 705                 710                 715                 720
 Gly Met Ser Lys Glu Lys Lys Glu Glu Trp Asp Arg Lys Ala Glu Asp
                 725                 730                 735    
 Ala Arg Arg Asp Tyr Glu Lys Ala Met Lys Glu Tyr Glu Gly Gly Arg
             740                 745                 750        
 Gly Glu Ser Ser Lys Arg Asp Lys Ser Lys Lys Lys Lys Lys Val Lys
         755                 760                 765            
 Val Lys Met Glu Lys Lys Ser Thr Pro Ser Arg Gly Ser Ser Ser Lys
     770                 775                 780                
 Ser Ser Ser Arg Gln Leu Ser Glu Ser Phe Lys Ser Lys Glu Phe Val
 785                 790                 795                 800
 Ser Ser Asp Glu Ser Ser Ser Gly Glu Asn Lys Ser Lys Lys Lys Arg
                 805                 810                 815    
 Arg Arg Ser Glu Asp Ser Glu Glu Glu Glu Leu Ala Ser Thr Pro Pro
             820                 825                 830        
 Ser Ser Glu Asp Ser Ala Ser Gly Ser Asp Glu
         835                 840            



      <210> 1091
      <211> 686
      <212> PRT
      <213> Homo sapiens


      <400> 1091
 Met Ala Ile Gly Leu Leu Met Ala Gln Glu Gly His Cys Lys Asp Ser
   1               5                  10                  15    
 Ser Ala Met Gly Glu Glu Ala His His Pro Leu Thr Pro Ala Thr Pro
              20                  25                  30        
 Pro Phe Pro Pro Leu Ser Pro Asp Trp Gly His Met Gln Pro Asp Phe
          35                  40                  45            
 Phe Val Pro Val Ala Val Pro Ala Val Phe Arg Gly Pro Pro Gln Leu
      50                  55                  60                
 Gln Cys His Gly Arg Arg Leu Phe Leu Asn Ser Pro Cys Ala Gln Lys
  65                  70                  75                  80
 Ser Ser Ser Gly Leu Val Val Glu Pro Gly Leu Ser Arg Thr Leu Leu
                  85                  90                  95    
 Glu Met Val Lys Leu Thr Ser Met Arg Gly Gln Phe Leu Glu Ala Gln
             100                 105                 110        
 Ile Pro Thr Gly Ile Ser Leu Thr Leu Gln Tyr Gln Leu Tyr Gln Lys
         115                 120                 125            
 Gln Thr Asn Lys Asn Met Ser Tyr Ser Phe Val Leu Phe Leu Lys Trp
     130                 135                 140                
 Val Ala Leu Gly Gln Gly Arg Arg Ala Gly Tyr Pro Ser Leu Glu Asp
 145                 150                 155                 160
 Ala Asp Ser Arg Arg Phe Asn Gly Ser Arg Ser Phe Leu Ile Thr Val
                 165                 170                 175    
 Ile Gly Ile Thr Leu Thr Val Glu Ile Val Thr Ser Gly Met Met Lys
             180                 185                 190        
 Gly Thr Arg Val Arg Trp Ser Gly Ala Gly Asn Glu Gly Met Met Gly
         195                 200                 205            
 Leu Glu Glu Gly Arg Asn Glu Arg Ser Val Lys Glu Ala Pro Pro Arg
     210                 215                 220                
 Arg Ala Val Glu Ala Gln Pro Lys Asp Arg Thr Trp Asp Val Gly Lys
 225                 230                 235                 240
 Gly Gln Gly Thr Glu Gly Glu Gly Arg Gly Leu Glu Val Glu Gly Gln
                 245                 250                 255    
 Gln His Gln Gly Ser Glu Pro Gly Thr Ile Pro Phe Ser Val Ser Trp
             260                 265                 270        
 Gly Val Leu Leu Leu Ala Gly Leu Cys Cys Leu Val Pro Ser Ser Leu
         275                 280                 285            
 Val Glu Asp Pro Gln Glu Asp Ala Ala Gln Lys Thr Asp Thr Ser His
     290                 295                 300                
 His Asp Gln Gly Asp Trp Glu Asp Leu Ala Cys Gln Lys Ile Ser Tyr
 305                 310                 315                 320
 Asn Val Thr Asp Leu Ala Phe Asp Leu Tyr Lys Glu Leu Ala Asp Leu
                 325                 330                 335    
 Ser Gln Thr Ser Asn Val Leu Val Thr Pro Thr Ser Val Ala Met Ala
             340                 345                 350        
 Phe Ala Met Leu Ser Leu Gly Thr Lys Ala Asp Thr Arg Thr Glu Ile
         355                 360                 365            
 Leu Glu Gly Leu Asn Val Asn Leu Thr Glu Thr Pro Glu Ala Lys Ile
     370                 375                 380                
 His Glu Cys Phe Gln Gln Val Leu Gln Ala Leu Ser Arg Pro Asp Thr
 385                 390                 395                 400
 Arg Leu Gln Leu Thr Thr Gly Ser Ser Leu Phe Val Asn Lys Ser Met
                 405                 410                 415    
 Lys Leu Val Asp Thr Phe Leu Glu Asp Thr Lys Lys Leu Tyr His Ser
             420                 425                 430        
 Glu Ala Ser Ser Ile Asn Phe Arg Asp Thr Glu Glu Ala Lys Glu Gln
         435                 440                 445            
 Ile Asn Asn Tyr Val Glu Lys Arg Thr Gly Arg Lys Val Val Asp Leu
     450                 455                 460                
 Val Lys His Leu Lys Lys Asp Thr Ser Leu Ala Leu Val Asp Tyr Ile
 465                 470                 475                 480
 Ser Phe His Gly Lys Trp Lys Asp Lys Phe Lys Ala Glu Arg Ile Met
                 485                 490                 495    
 Val Glu Gly Phe His Val Asp Asp Lys Thr Ile Ile Arg Val Pro Met
             500                 505                 510        
 Ile Asn His Leu Gly Arg Phe Asp Ile His Arg Asp Arg Glu Leu Ser
         515                 520                 525            
 Ser Trp Val Leu Ala Gln His Tyr Val Gly Asn Ala Thr Ala Phe Phe
     530                 535                 540                
 Ile Leu Pro Asp Pro Lys Lys Met Trp Gln Leu Glu Glu Lys Leu Thr
 545                 550                 555                 560
 Tyr Ser His Leu Glu Asn Ile Gln Arg Ala Phe Asp Ile Arg Ser Ile
                 565                 570                 575    
 Asn Leu His Phe Pro Lys Leu Ser Ile Ser Gly Thr Tyr Lys Leu Lys
             580                 585                 590        
 Arg Val Pro Arg Asn Leu Gly Ile Thr Lys Ile Phe Ser Asn Gly Ala
         595                 600                 605            
 Asp Leu Ser Gly Val Arg Glu Glu Ala Pro Leu Lys Leu Ser Lys Ala
     610                 615                 620                
 Val His Lys Ala Val Leu Thr Ile Asp Glu Lys Gly Thr Glu Ala Ala
 625                 630                 635                 640
 Gly Ala Met Phe Leu Glu Ala Ile Pro Met Ser Ile Pro Pro Gly Val
                 645                 650                 655    
 Lys Phe Lys Lys Pro Phe Val Phe Leu Met Ile Glu Gln Asn Thr Lys
             660                 665                 670        
 Ser Pro Leu Phe Met Gly Lys Val Val Asn Pro Thr Gln Lys
         675                 680                 685    



      <210> 1092
      <211> 566
      <212> PRT
      <213> Homo sapiens


      <400> 1092
 Met Arg Arg Gln Trp Gly Ser Ala Met Arg Ala Ala Glu Gln Ala Gly
   1               5                  10                  15    
 Cys Met Val Ser Ala Ser Arg Ala Gly Gln Pro Glu Ala Gly Pro Trp
              20                  25                  30        
 Ser Cys Ser Gly Val Ile Leu Ser Arg Ser Pro Gly Leu Val Leu Cys
          35                  40                  45            
 His Gly Gly Ile Phe Val Pro Phe Leu Arg Ala Gly Ser Glu Val Leu
      50                  55                  60                
 Ala Ala Ala Gly Ala Val Phe Leu Pro Gly Asp Ser Cys Arg Asp Asp
  65                  70                  75                  80
 Leu Arg Leu His Val Gln Trp Ala Pro Thr Ala Ala Gly Pro Gly Gly
                  85                  90                  95    
 Gly Ala Glu Arg Gly Arg Pro Gly Leu Cys Thr Pro Gln Cys Ala Ser
             100                 105                 110        
 Leu Glu Pro Gly Pro Pro Ala Pro Ser Arg Gly Arg Pro Leu Gln Pro
         115                 120                 125            
 Arg Leu Pro Ala Glu Leu Leu Leu Leu Leu Ser Cys Pro Ala Phe Trp
     130                 135                 140                
 Ala His Phe Ala Arg Leu Phe Gly Asp Glu Ala Ala Glu Gln Trp Arg
 145                 150                 155                 160
 Phe Ser Ser Ala Ala Arg Asp Asp Glu Val Ser Glu Asp Glu Glu Ala
                 165                 170                 175    
 Asp Gln Leu Arg Ala Leu Gly Trp Phe Ala Leu Leu Gly Val Arg Leu
             180                 185                 190        
 Gly Gln Glu Glu Val Glu Glu Glu Arg Gly Pro Ala Met Ala Val Ser
         195                 200                 205            
 Pro Leu Gly Ala Val Pro Lys Gly Ala Pro Leu Leu Val Cys Gly Ser
     210                 215                 220                
 Pro Phe Gly Ala Phe Cys Pro Asp Ile Phe Leu Asn Thr Leu Ser Cys
 225                 230                 235                 240
 Gly Val Leu Ser Asn Val Ala Gly Pro Leu Leu Leu Thr Asp Ala Arg
                 245                 250                 255    
 Cys Leu Pro Gly Thr Glu Gly Gly Gly Val Phe Thr Ala Arg Pro Ala
             260                 265                 270        
 Gly Ala Leu Val Ala Leu Val Val Ala Pro Leu Cys Trp Lys Ala Gly
         275                 280                 285            
 Glu Trp Val Gly Phe Thr Leu Leu Cys Ala Ala Ala Pro Leu Phe Arg
     290                 295                 300                
 Ala Ala Arg Asp Ala Leu His Arg Leu Pro His Ser Thr Ala Ala Leu
 305                 310                 315                 320
 Ala Ala Leu Leu Pro Pro Glu Val Gly Val Pro Trp Gly Leu Pro Leu
                 325                 330                 335    
 Arg Asp Ser Gly Pro Leu Trp Ala Ala Ala Ala Val Leu Val Glu Cys
             340                 345                 350        
 Gly Thr Val Trp Gly Ser Gly Val Ala Val Ala Pro Arg Leu Val Val
         355                 360                 365            
 Thr Cys Arg His Val Ser Pro Arg Glu Ala Ala Arg Val Leu Val Arg
     370                 375                 380                
 Ser Thr Thr Pro Lys Ser Val Ala Ile Trp Gly Arg Val Val Phe Ala
 385                 390                 395                 400
 Thr Gln Glu Thr Cys Pro Tyr Asp Ile Ala Val Val Ser Leu Glu Glu
                 405                 410                 415    
 Asp Leu Asp Asp Val Pro Ile Pro Val Pro Ala Glu His Phe His Glu
             420                 425                 430        
 Gly Glu Ala Val Ser Val Val Gly Phe Gly Val Phe Gly Gln Ser Cys
         435                 440                 445            
 Gly Pro Ser Val Thr Ser Gly Ile Leu Ser Ala Val Val Gln Val Asn
     450                 455                 460                
 Gly Thr Pro Val Met Leu Gln Thr Thr Cys Ala Val His Ser Gly Ser
 465                 470                 475                 480
 Ser Gly Gly Pro Leu Phe Ser Asn His Ser Gly Asn Leu Leu Gly Ile
                 485                 490                 495    
 Ile Thr Ser Asn Thr Arg Asp Asn Asn Thr Gly Ala Thr Tyr Pro His
             500                 505                 510        
 Leu Asn Phe Ser Ile Pro Ile Thr Val Leu Gln Pro Ala Leu Gln Gln
         515                 520                 525            
 Tyr Ser Gln Thr Gln Asp Leu Gly Gly Leu Arg Glu Leu Asp Arg Ala
     530                 535                 540                
 Ala Glu Pro Val Arg Val Val Trp Arg Leu Gln Arg Pro Leu Ala Glu
 545                 550                 555                 560
 Ala Pro Arg Ser Lys Leu
                 565    



      <210> 1093
      <211> 295
      <212> PRT
      <213> Homo sapiens


      <400> 1093
 Met Lys Gly Gly Glu Gly Asp Ala Gly Glu Gln Ala Pro Leu Asn Pro
   1               5                  10                  15    
 Glu Gly Glu Ser Pro Ala Gly Ser Ala Thr Tyr Arg Glu Phe Val His
              20                  25                  30        
 Arg Gly Tyr Leu Asp Leu Met Gly Ala Ser Gln His Ser Leu Arg Ala
          35                  40                  45            
 Leu Ser Trp Arg Arg Leu Tyr Leu Ser Arg Ala Lys Leu Lys Ala Ser
      50                  55                  60                
 Ser Arg Thr Ser Ala Leu Leu Ser Gly Phe Ala Met Val Ala Met Val
  65                  70                  75                  80
 Glu Val Gln Leu Glu Ser Asp His Glu Tyr Pro Pro Gly Leu Leu Val
                  85                  90                  95    
 Ala Phe Ser Ala Cys Thr Thr Val Leu Val Ala Val His Leu Phe Ala
             100                 105                 110        
 Leu Met Val Ser Thr Cys Leu Leu Pro His Ile Glu Ala Val Ser Asn
         115                 120                 125            
 Ile His Asn Leu Asn Ser Val His Gln Ser Pro His Gln Arg Leu His
     130                 135                 140                
 Arg Tyr Val Glu Leu Ala Trp Gly Phe Ser Thr Ala Leu Gly Thr Phe
 145                 150                 155                 160
 Leu Phe Leu Ala Glu Val Val Leu Val Gly Trp Val Lys Phe Val Pro
                 165                 170                 175    
 Ile Gly Ala Pro Leu Asp Thr Pro Thr Pro Met Val Pro Thr Ser Arg
             180                 185                 190        
 Val Pro Gly Thr Leu Ala Pro Val Ala Thr Ser Leu Ser Pro Ala Ser
         195                 200                 205            
 Asn Leu Pro Arg Ser Ser Ala Ser Ala Ala Pro Ser Gln Ala Glu Pro
     210                 215                 220                
 Ala Cys Pro Pro Arg Gln Ala Cys Gly Gly Gly Gly Ala His Gly Pro
 225                 230                 235                 240
 Gly Trp Gln Ala Ala Met Ala Ser Thr Ala Ile Met Val Pro Val Gly
                 245                 250                 255    
 Leu Val Phe Val Ala Phe Ala Leu His Phe Tyr Arg Ser Leu Val Ala
             260                 265                 270        
 His Lys Thr Asp Arg Tyr Lys Gln Glu Leu Glu Glu Leu Asn Arg Leu
         275                 280                 285            
 Gln Gly Glu Leu Gln Ala Val
     290                 295



      <210> 1094
      <211> 561
      <212> PRT
      <213> Homo sapiens


      <400> 1094
 Met Ala Asn Met Asn Ser Asp Ser Arg His Leu Gly Thr Ser Glu Val
   1               5                  10                  15    
 Asp His Glu Arg Asp Pro Gly Pro Met Asn Ile Gln Phe Glu Pro Ser
              20                  25                  30        
 Asp Leu Arg Ser Lys Arg Pro Phe Cys Ile Glu Pro Thr Asn Ile Val
          35                  40                  45            
 Asn Val Asn His Val Ile Gln Arg Val Ser Asp His Ala Ser Ala Met
      50                  55                  60                
 Asn Lys Arg Ile His Tyr Tyr Ser Arg Leu Thr Thr Pro Ala Asp Lys
  65                  70                  75                  80
 Ala Leu Ile Ala Pro Asp His Val Val Pro Ala Pro Glu Glu Cys Tyr
                  85                  90                  95    
 Val Tyr Ser Pro Leu Gly Ser Ala Tyr Lys Leu Gln Ser Tyr Thr Glu
             100                 105                 110        
 Gly Tyr Gly Lys Asn Thr Ser Leu Val Thr Ile Phe Met Ile Trp Asn
         115                 120                 125            
 Thr Met Met Gly Thr Ser Ile Leu Ser Ile Pro Trp Gly Ile Lys Gln
     130                 135                 140                
 Ala Gly Phe Thr Thr Gly Met Cys Val Ile Ile Leu Met Gly Leu Leu
 145                 150                 155                 160
 Thr Leu Tyr Cys Cys Tyr Arg Val Val Lys Ser Arg Thr Met Met Phe
                 165                 170                 175    
 Ser Leu Asp Thr Thr Ser Trp Glu Tyr Pro Asp Val Cys Arg His Tyr
             180                 185                 190        
 Phe Gly Ser Phe Gly Gln Trp Ser Ser Leu Leu Phe Ser Leu Val Ser
         195                 200                 205            
 Leu Ile Gly Ala Met Ile Val Tyr Trp Val Leu Met Ser Asn Phe Leu
     210                 215                 220                
 Phe Asn Thr Gly Lys Phe Ile Phe Asn Phe Ile His His Ile Asn Asp
 225                 230                 235                 240
 Thr Asp Thr Ile Leu Ser Thr Asn Asn Ser Asn Pro Val Ile Cys Pro
                 245                 250                 255    
 Ser Ala Gly Ser Gly Gly His Pro Asp Asn Ser Ser Met Ile Phe Tyr
             260                 265                 270        
 Ala Asn Asp Thr Gly Ala Gln Gln Phe Glu Lys Trp Trp Asp Lys Ser
         275                 280                 285            
 Arg Thr Val Pro Phe Tyr Leu Val Gly Leu Leu Leu Pro Leu Leu Asn
     290                 295                 300                
 Phe Lys Ser Pro Ser Phe Phe Ser Lys Phe Asn Ile Leu Gly Thr Val
 305                 310                 315                 320
 Ser Val Leu Tyr Leu Ile Phe Leu Val Thr Phe Lys Ala Val Arg Leu
                 325                 330                 335    
 Gly Phe His Leu Glu Phe His Trp Phe Ile Pro Thr Glu Phe Phe Val
             340                 345                 350        
 Pro Glu Ile Arg Phe Gln Phe Pro Gln Leu Thr Gly Val Leu Thr Leu
         355                 360                 365            
 Ala Phe Phe Ile His Asn Cys Ile Ile Thr Leu Leu Lys Asn Asn Lys
     370                 375                 380                
 Lys Gln Glu Asn Asn Val Arg Asp Leu Cys Ile Ala Tyr Met Leu Val
 385                 390                 395                 400
 Thr Leu Thr Tyr Leu Tyr Ile Gly Val Leu Val Phe Ala Ser Phe Pro
                 405                 410                 415    
 Ser Pro Pro Leu Ser Lys Asp Cys Ile Glu Gln Asn Phe Leu Asp Asn
             420                 425                 430        
 Phe Pro Ser Ser Asp Thr Leu Ser Phe Ile Ala Arg Ile Phe Leu Leu
         435                 440                 445            
 Phe Gln Met Met Thr Val Tyr Pro Leu Leu Gly Tyr Leu Ala Arg Val
     450                 455                 460                
 Gln Leu Leu Gly His Ile Phe Gly Asp Ile Tyr Pro Ser Ile Phe His
 465                 470                 475                 480
 Val Leu Ile Leu Asn Leu Ile Ile Val Gly Ala Gly Val Ile Met Ala
                 485                 490                 495    
 Cys Phe Tyr Pro Asn Ile Gly Gly Ile Ile Arg Tyr Ser Gly Ala Ala
             500                 505                 510        
 Cys Gly Leu Ala Phe Val Phe Ile Tyr Pro Ser Leu Ile Tyr Ile Ile
         515                 520                 525            
 Ser Leu His Gln Glu Glu Arg Leu Thr Trp Pro Lys Leu Ile Phe His
     530                 535                 540                
 Val Phe Ile Ile Ile Leu Gly Val Ala Asn Leu Ile Val Gln Phe Phe
 545                 550                 555                 560
 Met
    



      <210> 1095
      <211> 369
      <212> PRT
      <213> Homo sapiens


      <400> 1095
 Met Val Lys Leu Ser Ile Val Leu Thr Pro Gln Phe Leu Ser His Asp
   1               5                  10                  15    
 Gln Gly Gln Leu Thr Lys Glu Leu Gln Gln His Val Lys Ser Val Thr
              20                  25                  30        
 Cys Pro Cys Glu Tyr Leu Arg Lys Val Ile Asn Thr Leu Ala Asp His
          35                  40                  45            
 His His Arg Gly Thr Asp Phe Gly Gly Ser Pro Trp Leu His Val Ile
      50                  55                  60                
 Ile Ala Phe Pro Thr Ser Tyr Lys Val Val Ile Thr Leu Trp Ile Val
  65                  70                  75                  80
 Tyr Leu Trp Val Ser Leu Leu Lys Thr Ile Phe Trp Ser Arg Asn Gly
                  85                  90                  95    
 His Asp Gly Ser Thr Asp Val Gln Gln Arg Ala Arg Arg Ser Asn Arg
             100                 105                 110        
 Arg Arg Gln Glu Gly Ile Lys Ile Val Leu Glu Asp Ile Phe Thr Leu
         115                 120                 125            
 Trp Arg Gln Val Glu Thr Lys Val Arg Ala Lys Ile Arg Lys Met Lys
     130                 135                 140                
 Val Thr Thr Lys Val Asn Arg His Asp Lys Ile Asn Gly Lys Arg Lys
 145                 150                 155                 160
 Thr Ala Lys Glu His Leu Arg Lys Leu Ser Met Lys Glu Arg Glu His
                 165                 170                 175    
 Gly Glu Lys Glu Arg Gln Val Ser Glu Ala Glu Glu Asn Gly Lys Leu
             180                 185                 190        
 Asp Met Lys Glu Ile His Thr Tyr Met Glu Met Phe Gln Arg Ala Gln
         195                 200                 205            
 Ala Leu Arg Arg Arg Ala Glu Asp Tyr Tyr Arg Cys Lys Ile Thr Pro
     210                 215                 220                
 Ser Ala Arg Lys Pro Leu Cys Asn Arg Val Arg Met Ala Ala Val Glu
 225                 230                 235                 240
 His Arg His Ser Ser Gly Leu Pro Tyr Trp Pro Tyr Leu Thr Ala Glu
                 245                 250                 255    
 Thr Leu Lys Asn Arg Met Gly His Gln Pro Pro Pro Pro Thr Gln Gln
             260                 265                 270        
 His Ser Ile Ile Asp Asn Ser Leu Ser Leu Lys Thr Pro Ser Glu Cys
         275                 280                 285            
 Leu Leu Thr Pro Leu Pro Pro Ser Ala Leu Pro Ser Ala Asp Asp Asn
     290                 295                 300                
 Leu Lys Thr Pro Ala Glu Cys Leu Leu Tyr Pro Leu Pro Pro Ser Ala
 305                 310                 315                 320
 Asp Asp Asn Leu Lys Thr Pro Pro Glu Cys Leu Leu Thr Pro Leu Pro
                 325                 330                 335    
 Pro Ser Ala Pro Pro Ser Ala Asp Asp Asn Leu Lys Thr Pro Pro Glu
             340                 345                 350        
 Cys Val Cys Ser Leu Pro Phe His Pro Gln Arg Met Ile Ile Ser Arg
         355                 360                 365            
 Asn
    



      <210> 1096
      <211> 272
      <212> PRT
      <213> Homo sapiens


      <400> 1096
 Met Gly Tyr Phe Leu Lys Leu Tyr Ala Tyr Val Asn Ser His Ser Leu
   1               5                  10                  15    
 Phe Val Trp Val Cys Asp Arg Ser Tyr Lys Arg Ser Phe Arg Pro Met
              20                  25                  30        
 Ile Leu Asn Lys Ile Lys Glu Leu Ser Arg Asn Gln Phe Pro Thr Met
          35                  40                  45            
 Ser His Leu Arg Lys Asp Ser Gln Pro Ser Ser Pro Gly Asp Asp Ala
      50                  55                  60                
 Met Asp Arg Ser Gly Leu Pro Asp Leu Gln Gly Arg Phe Glu Leu Ser
  65                  70                  75                  80
 Gly Lys Asn Arg Gln Tyr Pro Leu Asp Ala Leu Glu Pro Gln Pro Ser
                  85                  90                  95    
 Ile Gly Asp Ile Lys Asp Ile Lys Lys Ala Ala Lys Ser Met Leu Asp
             100                 105                 110        
 Pro Ala His Lys Ser His Phe His Pro Val Thr Pro Ser Leu Val Phe
         115                 120                 125            
 Leu Cys Phe Ile Phe Asp Gly Leu His Gln Ala Leu Leu Ser Val Gly
     130                 135                 140                
 Val Ser Lys Arg Ser Asn Thr Val Val Gly Asn Glu Asn Glu Glu Arg
 145                 150                 155                 160
 Gly Thr Pro Tyr Ala Ser Arg Phe Lys Asp Met Pro Asn Phe Ile Ala
                 165                 170                 175    
 Leu Glu Lys Ser Ser Val Leu Arg His Cys Cys Asp Leu Leu Ile Gly
             180                 185                 190        
 Ile Ala Ala Gly Ser Ser Asp Lys Ile Cys Thr Ser Ser Leu Gln Val
         195                 200                 205            
 Gln Arg Arg Phe Lys Ala Met Met Ala Ser Ile Gly Arg Leu Ser His
     210                 215                 220                
 Gly Glu Ser Ala Asp Leu Leu Ile Ser Cys Asn Ala Glu Ser Ala Ile
 225                 230                 235                 240
 Gly Trp Ile Ser Ser Arg Pro Trp Val Gly Glu Leu Met Phe Thr Phe
                 245                 250                 255    
 Leu Phe Gly Asp Phe Glu Ser Pro Leu His Lys Leu Arg Lys Ser Ser
             260                 265                 270        





      <210> 1097
      <211> 141
      <212> PRT
      <213> Homo sapiens


      <400> 1097
 Met Phe Ala Cys Ser Lys Phe Val Ser Thr Pro Ser Leu Val Asn Arg
   1               5                  10                  15    
 Ala Leu Gln Leu Leu Ser Arg Pro Leu Ser Ala Met Val Leu Lys Arg
              20                  25                  30        
 Pro Glu Ile Leu Thr Asp Glu Ser Leu Ser Ser Leu Ala Val Ser Cys
          35                  40                  45            
 Pro Leu Thr Ser Leu Asp Ser Ser Arg Ser Phe Gln Thr Ser Ala Ile
      50                  55                  60                
 Ser Arg Asp Ile Asp Thr Ala Ala Lys Phe Ile Gly Thr Gly Ala Val
  65                  70                  75                  80
 Thr Val Gly Val Ala Gly Phe Gly Ala Gly Ile Gly Thr Val Phe Gly
                  85                  90                  95    
 Ser Leu Ile Ile Gly Tyr Ala Arg Asn Pro Phe Leu Lys Gln Gln Leu
             100                 105                 110        
 Phe Ser Tyr Ala Ile Leu Gly Phe Ala Leu Ser Glu Ala Met Gly Leu
         115                 120                 125            
 Phe Cys Leu Lys Glu Ala Phe Phe Ile Leu Phe Ala Met
     130                 135                 140    



      <210> 1098
      <211> 1068
      <212> PRT
      <213> Homo sapiens


      <400> 1098
 Met Val Ser Gly Asp Gly Arg Pro Lys Ser Arg Ser Val Ser Gly Leu
   1               5                  10                  15    
 Arg Ala Gly Ser Gly Ser Trp Lys Arg Ala Leu Pro Arg Arg Arg Ile
              20                  25                  30        
 Pro Cys Phe Ser Arg Leu Glu Ser Leu Gly Arg Arg Pro Gly Pro Arg
          35                  40                  45            
 Gly Ser Gly Cys Ala Pro Leu Gly Ala Cys Leu Leu Gly Arg Pro Leu
      50                  55                  60                
 Ser Leu Gly Arg Gly Ser Trp Gly Ser Arg Ser Pro Pro Ser Cys Ala
  65                  70                  75                  80
 Thr Pro Ala Gly Arg Ala Thr Pro Pro Leu Ala Leu Thr Arg Thr Pro
                  85                  90                  95    
 Leu Ser Pro Val Ala Ala Ala Cys Cys Gln Arg Leu Pro Gly Pro Arg
             100                 105                 110        
 Tyr Ala Phe Glu Tyr Leu Ile Glu Thr Leu Asn Asp Ser Ser His Lys
         115                 120                 125            
 Lys Phe Phe Asp Val Ser Lys Leu Gly Thr Lys Tyr Asp Val Leu Pro
     130                 135                 140                
 Tyr Ser Ile Arg Val Leu Leu Glu Ala Ala Val Arg Asn Cys Asp Gly
 145                 150                 155                 160
 Phe Leu Met Lys Lys Glu Asp Val Met Asn Ile Leu Asp Trp Lys Thr
                 165                 170                 175    
 Lys Gln Ser Asn Val Glu Val Pro Phe Phe Pro Ala Arg Val Leu Leu
             180                 185                 190        
 Gln Asp Phe Thr Gly Ile Pro Ala Met Val Asp Phe Ala Ala Met Arg
         195                 200                 205            
 Glu Ala Val Lys Thr Leu Gly Gly Asp Pro Glu Lys Val His Pro Ala
     210                 215                 220                
 Cys Pro Thr Asp Leu Thr Val Asp His Ser Leu Gln Ile Asp Phe Ser
 225                 230                 235                 240
 Lys Cys Ala Ile Gln Asn Ala Pro Asn Pro Gly Gly Gly Asp Leu Gln
                 245                 250                 255    
 Lys Ala Gly Lys Leu Ser Pro Leu Lys Val Gln Pro Lys Lys Leu Pro
             260                 265                 270        
 Cys Arg Gly Gln Thr Thr Cys Arg Gly Ser Cys Asp Ser Gly Glu Leu
         275                 280                 285            
 Gly Arg Asn Ser Gly Thr Phe Ser Ser Gln Ile Glu Asn Thr Pro Ile
     290                 295                 300                
 Leu Cys Pro Phe His Leu Gln Pro Val Pro Glu Pro Glu Thr Val Leu
 305                 310                 315                 320
 Lys Asn Gln Glu Val Glu Phe Gly Arg Asn Arg Glu Arg Leu Gln Phe
                 325                 330                 335    
 Phe Lys Trp Ser Ser Arg Val Leu Lys Asn Val Ala Val Ile Pro Pro
             340                 345                 350        
 Gly Thr Gly Met Ala His Gln Ile Asn Leu Glu Tyr Leu Ser Arg Val
         355                 360                 365            
 Val Phe Glu Glu Lys Asp Leu Leu Phe Pro Asp Ser Val Val Gly Thr
     370                 375                 380                
 Asp Ser His Ile Thr Met Val Asn Gly Leu Gly Ile Leu Gly Trp Gly
 385                 390                 395                 400
 Val Gly Gly Ile Glu Thr Glu Ala Val Met Leu Gly Leu Pro Val Ser
                 405                 410                 415    
 Leu Thr Leu Pro Glu Val Val Gly Cys Glu Leu Thr Gly Ser Ser Asn
             420                 425                 430        
 Pro Phe Val Thr Ser Ile Asp Val Val Leu Gly Ile Thr Lys His Leu
         435                 440                 445            
 Arg Gln Val Gly Val Ala Gly Lys Phe Val Glu Phe Phe Gly Ser Gly
     450                 455                 460                
 Val Ser Gln Leu Ser Ile Val Asp Arg Thr Thr Ile Ala Asn Met Cys
 465                 470                 475                 480
 Pro Glu Tyr Gly Ala Ile Leu Ser Phe Phe Pro Val Asp Asn Val Thr
                 485                 490                 495    
 Leu Lys His Leu Glu His Thr Gly Phe Ser Lys Ala Lys Leu Glu Ser
             500                 505                 510        
 Met Glu Thr Tyr Leu Lys Ala Val Lys Leu Phe Arg Asn Asp Gln Asn
         515                 520                 525            
 Ser Ser Gly Glu Pro Glu Tyr Ser Gln Val Ile Gln Ile Asn Leu Asn
     530                 535                 540                
 Ser Ile Val Pro Ser Val Ser Gly Pro Lys Arg Pro Gln Asp Arg Val
 545                 550                 555                 560
 Ala Val Thr Asp Met Lys Ser Asp Phe Gln Ala Cys Leu Asn Glu Lys
                 565                 570                 575    
 Val Gly Phe Lys Gly Phe Gln Ile Ala Ala Glu Lys Gln Lys Asp Ile
             580                 585                 590        
 Val Ser Ile His Tyr Glu Gly Ser Glu Tyr Lys Leu Ser His Gly Ser
         595                 600                 605            
 Val Val Ile Ala Ala Val Ile Ser Cys Thr Asn Asn Cys Asn Pro Ser
     610                 615                 620                
 Val Met Leu Ala Ala Gly Leu Leu Ala Lys Lys Ala Val Glu Ala Gly
 625                 630                 635                 640
 Leu Arg Val Lys Pro Tyr Ile Arg Thr Ser Leu Ser Pro Gly Ser Gly
                 645                 650                 655    
 Met Val Thr His Tyr Leu Ser Ser Ser Gly Val Leu Pro Tyr Leu Ser
             660                 665                 670        
 Lys Leu Gly Phe Glu Ile Val Gly Tyr Gly Cys Ser Thr Cys Val Gly
         675                 680                 685            
 Asn Thr Ala Pro Leu Ser Asp Ala Val Leu Asn Ala Val Lys Gln Gly
     690                 695                 700                
 Asp Leu Val Thr Cys Gly Ile Leu Ser Gly Asn Lys Asn Phe Glu Gly
 705                 710                 715                 720
 Arg Leu Cys Asp Cys Val Arg Ala Asn Tyr Leu Ala Ser Pro Pro Leu
                 725                 730                 735    
 Val Val Ala Tyr Ala Ile Ala Gly Thr Val Asn Ile Asp Phe Gln Thr
             740                 745                 750        
 Glu Pro Leu Gly Thr Asp Pro Thr Gly Lys Asn Ile Tyr Leu His Asp
         755                 760                 765            
 Ile Trp Pro Ser Arg Glu Glu Val His Arg Val Glu Glu Glu His Val
     770                 775                 780                
 Ile Leu Ser Met Phe Lys Ala Leu Lys Asp Lys Ile Glu Met Gly Asn
 785                 790                 795                 800
 Lys Arg Trp Asn Ser Leu Glu Ala Pro Asp Ser Val Leu Phe Pro Trp
                 805                 810                 815    
 Asp Leu Lys Ser Thr Tyr Ile Arg Cys Pro Ser Phe Phe Asp Lys Leu
             820                 825                 830        
 Thr Lys Glu Pro Ile Ala Leu Gln Ala Ile Glu Asn Ala His Val Leu
         835                 840                 845            
 Leu Tyr Leu Gly Asp Ser Val Thr Thr Asp His Ile Ser Pro Ala Gly
     850                 855                 860                
 Ser Ile Ala Arg Asn Ser Ala Ala Ala Lys Tyr Leu Thr Asn Arg Gly
 865                 870                 875                 880
 Leu Thr Pro Arg Glu Phe Asn Ser Tyr Gly Ala Arg Arg Gly Asn Asp
                 885                 890                 895    
 Ala Val Met Thr Arg Gly Thr Phe Ala Asn Ile Lys Leu Phe Asn Lys
             900                 905                 910        
 Phe Ile Gly Lys Pro Ala Pro Lys Thr Ile His Phe Pro Ser Gly Gln
         915                 920                 925            
 Thr Leu Asp Val Phe Glu Ala Ala Glu Leu Tyr Gln Lys Glu Gly Ile
     930                 935                 940                
 Pro Leu Ile Ile Leu Ala Gly Lys Lys Tyr Gly Ser Gly Asn Ser Arg
 945                 950                 955                 960
 Asp Trp Ala Ala Lys Gly Pro Tyr Leu Leu Gly Val Lys Ala Val Leu
                 965                 970                 975    
 Ala Glu Ser Tyr Glu Lys Ile His Lys Asp His Leu Ile Gly Ile Gly
             980                 985                 990        
 Ile Ala Pro Leu Gln Phe Leu Pro Gly Glu Asn Ala Asp Ser Leu Gly
         995                1000                1005            
 Leu Ser Gly Arg Glu Thr Phe Ser Leu Thr Phe Pro Glu Glu Leu Ser
    1010                1015                1020                
 Pro Gly Ile Thr Leu Asn Ile Gln Thr Ser Thr Gly Lys Val Phe Ser
1025                1030                1035                1040
 Val Ile Ala Ser Phe Glu Asp Asp Val Glu Ile Thr Leu Tyr Lys His
                1045                1050                1055    
 Gly Gly Leu Leu Asn Phe Val Ala Arg Lys Phe Ser
            1060                1065            



      <210> 1099
      <211> 198
      <212> PRT
      <213> Homo sapiens


      <400> 1099
 Met Tyr Lys Glu Asn Leu Val Arg Ile Phe Arg Lys Lys Lys Arg Ile
   1               5                  10                  15    
 Cys His Ser Phe Ser Ser Leu Phe Asn Leu Ser Thr Ser Lys Ser Trp
              20                  25                  30        
 Leu His Gly Ser Ile Phe Gly Asp Ile Asn Ser Ser Pro Ser Glu Asp
          35                  40                  45            
 Asn Trp Leu Lys Gly Thr Arg Arg Leu Asp Thr Asp His Cys Asn Gly
      50                  55                  60                
 Asn Ala Asp Asp Leu Asp Cys Ser Ser Leu Thr Asp Asp Trp Glu Ser
  65                  70                  75                  80
 Gly Lys Met Asn Ala Glu Ser Val Ile Thr Ser Ser Ser Ser His Ile
                  85                  90                  95    
 Ile Ser Gln Pro Pro Gly Gly Asn Ser His Ser Leu Ser Leu Gln Ser
             100                 105                 110        
 Gln Leu Thr Ala Ser Glu Arg Phe Gln Glu Asn Ser Ser Asp His Ser
         115                 120                 125            
 Glu Thr Arg Leu Leu Gln Glu Val Phe Phe Gln Ala Ile Leu Leu Ala
     130                 135                 140                
 Val Cys Leu Ile Ile Ser Ala Cys Ala Arg Trp Phe Met Gly Glu Ile
 145                 150                 155                 160
 Leu Ala Ser Val Phe Thr Cys Ser Leu Met Ile Thr Val Ala Tyr Val
                 165                 170                 175    
 Lys Ser Leu Phe Leu Ser Leu Ala Ser Tyr Phe Lys Thr Thr Ala Cys
             180                 185                 190        
 Ala Arg Phe Val Lys Ile
         195            



      <210> 1100
      <211> 294
      <212> PRT
      <213> Homo sapiens


      <400> 1100
 Met Ile His Ser Thr Ser Leu Ser Phe Val Tyr Ala Gly Ser Ser Arg
   1               5                  10                  15    
 Leu Glu Arg Glu Tyr Ala Gly Glu Leu Ser Pro Thr Cys Ile Phe Pro
              20                  25                  30        
 Ser Phe Thr Cys Asp Ser Leu Asp Gly Tyr His Ser Phe Glu Cys Gly
          35                  40                  45            
 Ser Ile Asp Pro Leu Thr Gly Ser His Tyr Thr Cys Arg Arg Ser Pro
      50                  55                  60                
 Arg Leu Leu Thr Asn Gly Tyr Tyr Ile Trp Thr Glu Asp Ser Phe Leu
  65                  70                  75                  80
 Cys Asp Lys Asp Gly Asn Ile Thr Leu Asn Pro Ser Gln Thr Ser Val
                  85                  90                  95    
 Met Tyr Lys Glu Asn Leu Val Arg Ile Phe Arg Lys Lys Lys Arg Ile
             100                 105                 110        
 Cys His Ser Phe Ser Ser Leu Phe Asn Leu Ser Thr Ser Lys Ser Trp
         115                 120                 125            
 Leu His Gly Ser Ile Phe Gly Asp Ile Asn Ser Ser Pro Ser Glu Asp
     130                 135                 140                
 Asn Trp Leu Lys Gly Thr Arg Arg Leu Asp Thr Asp His Cys Asn Gly
 145                 150                 155                 160
 Asn Ala Asp Asp Leu Asp Cys Ser Ser Leu Thr Asp Asp Trp Glu Ser
                 165                 170                 175    
 Gly Lys Met Asn Ala Glu Ser Val Ile Thr Ser Ser Ser Ser His Ile
             180                 185                 190        
 Ile Ser Gln Pro Pro Gly Gly Asn Ser His Ser Leu Ser Leu Gln Ser
         195                 200                 205            
 Gln Leu Thr Ala Ser Glu Arg Phe Gln Glu Asn Ser Ser Asp His Ser
     210                 215                 220                
 Glu Thr Arg Leu Leu Gln Glu Val Phe Phe Gln Ala Ile Leu Leu Ala
 225                 230                 235                 240
 Val Cys Leu Ile Ile Ser Ala Cys Ala Arg Trp Phe Met Gly Glu Ile
                 245                 250                 255    
 Leu Ala Ser Val Phe Thr Cys Ser Leu Met Ile Thr Val Ala Tyr Val
             260                 265                 270        
 Lys Ser Leu Phe Leu Ser Leu Ala Ser Tyr Phe Lys Thr Thr Ala Cys
         275                 280                 285            
 Ala Arg Phe Val Lys Ile
     290                



      <210> 1101
      <211> 248
      <212> PRT
      <213> Homo sapiens


      <400> 1101
 Met Arg Leu His Arg Ser Pro Asp Arg Leu Pro Leu Tyr Leu Ser Pro
   1               5                  10                  15    
 Lys Pro Arg Leu Leu Thr Asn Gly Tyr Tyr Ile Trp Thr Glu Asp Ser
              20                  25                  30        
 Phe Leu Cys Asp Lys Asp Gly Asn Ile Thr Leu Asn Pro Ser Gln Thr
          35                  40                  45            
 Ser Val Met Tyr Lys Glu Asn Leu Val Arg Ile Phe Arg Lys Lys Lys
      50                  55                  60                
 Arg Ile Cys His Ser Phe Ser Ser Leu Phe Asn Leu Ser Thr Ser Lys
  65                  70                  75                  80
 Ser Trp Leu His Gly Ser Ile Phe Gly Asp Ile Asn Ser Ser Pro Ser
                  85                  90                  95    
 Glu Asp Asn Trp Leu Lys Gly Thr Arg Arg Leu Asp Thr Asp His Cys
             100                 105                 110        
 Asn Gly Asn Ala Asp Asp Leu Asp Cys Ser Ser Leu Thr Asp Asp Trp
         115                 120                 125            
 Glu Ser Gly Lys Met Asn Ala Glu Ser Val Ile Thr Ser Ser Ser Ser
     130                 135                 140                
 His Ile Ile Ser Gln Pro Pro Gly Gly Asn Ser His Ser Leu Ser Leu
 145                 150                 155                 160
 Gln Ser Gln Leu Thr Ala Ser Glu Arg Phe Gln Glu Asn Ser Ser Asp
                 165                 170                 175    
 His Ser Glu Thr Arg Leu Leu Gln Glu Val Phe Phe Gln Ala Ile Leu
             180                 185                 190        
 Leu Ala Val Cys Leu Ile Ile Ser Ala Cys Ala Arg Trp Phe Met Gly
         195                 200                 205            
 Glu Ile Leu Ala Ser Val Phe Thr Cys Ser Leu Met Ile Thr Val Ala
     210                 215                 220                
 Tyr Val Lys Ser Leu Phe Leu Ser Leu Ala Ser Tyr Phe Lys Thr Thr
 225                 230                 235                 240
 Ala Cys Ala Arg Phe Val Lys Ile
                 245            



      <210> 1102
      <211> 160
      <212> PRT
      <213> Homo sapiens


      <400> 1102
 Met Ser Glu Ala Ser Arg Leu Cys Ser Gly Tyr Tyr Ser Leu Asn Gln
   1               5                  10                  15    
 Ser Phe Val Glu Pro Phe Gln Cys Pro Arg Arg Gly Glu Gly Ala Ala
              20                  25                  30        
 Leu Gln Tyr Cys Cys Gly Phe Ala Asp Leu Lys Tyr Cys Cys Ser Glu
          35                  40                  45            
 Pro Gly Ser Tyr Phe Pro Tyr Lys His Ser Tyr Met Trp Ser Leu Ser
      50                  55                  60                
 Ile Gly Ala Leu Ile Gly Leu Gly Ile Ala Ala Leu Val Leu Leu Ala
  65                  70                  75                  80
 Phe Val Ile Ser Val Cys Val Leu Cys Tyr Leu Phe Leu Tyr Thr Lys
                  85                  90                  95    
 Pro Gln Arg Leu Asp Thr Gly Leu Lys Leu Gln His Leu Glu Ala Ser
             100                 105                 110        
 Ser Thr Gln Glu Gly Lys Ser Asn Gly Lys Thr Lys Ala Leu Asn Ser
         115                 120                 125            
 Asn Ala Ala Ser Asn Ala Thr Asn Glu Thr Tyr Tyr Glu Ala Asp Asp
     130                 135                 140                
 Ile Ile Gln Glu Lys Thr Met Asp Ala Thr Gln Ile His Ile Ala Tyr
 145                 150                 155                 160





      <210> 1103
      <211> 394
      <212> PRT
      <213> Homo sapiens


      <400> 1103
 Met Ser Leu Arg Gln Arg Leu Ala Gln Leu Val Gly Arg Leu Gln Asp
   1               5                  10                  15    
 Pro Gln Lys Val Ala Arg Phe Gln Arg Arg Asn Gln Cys Pro Ala Lys
              20                  25                  30        
 Pro Asp Gly Gly Gly Ala Pro Asn Gly Val Arg Asn Gly Leu Ala Ala
          35                  40                  45            
 Glu Leu Gly Pro Ala Ser Pro Arg Arg Ala Gly Ala Leu Arg Arg Asn
      50                  55                  60                
 Ser Leu Thr Gly Glu Glu Gly Gln Leu Ala Arg Val Ser Asn Trp Pro
  65                  70                  75                  80
 Leu Tyr Cys Leu Phe Cys Phe Gly Thr Glu Leu Gly Asn Glu Leu Phe
                  85                  90                  95    
 Tyr Ile Leu Phe Phe Pro Phe Trp Ile Trp Asn Leu Asp Pro Leu Val
             100                 105                 110        
 Gly Arg Arg Leu Val Val Ile Trp Val Leu Val Met Tyr Leu Gly Gln
         115                 120                 125            
 Cys Thr Lys Asp Ile Ile Arg Trp Pro Arg Pro Ala Ser Pro Pro Val
     130                 135                 140                
 Val Lys Leu Glu Val Phe Tyr Asn Ser Glu Tyr Ser Met Pro Ser Thr
 145                 150                 155                 160
 His Ala Met Ser Gly Thr Ala Ile Pro Ile Ser Met Val Leu Leu Thr
                 165                 170                 175    
 Tyr Gly Arg Trp Gln Tyr Pro Leu Ile Tyr Gly Leu Ile Leu Ile Pro
             180                 185                 190        
 Cys Trp Cys Ser Leu Val Cys Leu Ser Arg Ile Tyr Met Gly Met His
         195                 200                 205            
 Ser Ile Leu Asp Ile Ile Ala Gly Phe Leu Tyr Thr Ile Leu Ile Leu
     210                 215                 220                
 Ala Val Phe Tyr Pro Phe Val Asp Leu Ile Asp Asn Phe Asn Gln Thr
 225                 230                 235                 240
 His Lys Tyr Ala Pro Phe Ile Ile Ile Gly Leu His Leu Ala Leu Gly
                 245                 250                 255    
 Ile Phe Ser Phe Thr Leu Asp Thr Trp Ser Thr Ser Arg Gly Asp Thr
             260                 265                 270        
 Ala Glu Ile Leu Gly Ser Gly Ala Gly Ile Ala Cys Gly Ser His Val
         275                 280                 285            
 Thr Tyr Asn Met Gly Leu Val Leu Asp Pro Ser Leu Asp Thr Leu Pro
     290                 295                 300                
 Leu Ala Gly Pro Pro Ile Thr Val Thr Leu Phe Gly Lys Ala Ile Leu
 305                 310                 315                 320
 Arg Ile Leu Ile Gly Met Val Phe Val Leu Ile Ile Arg Asp Val Met
                 325                 330                 335    
 Lys Lys Ile Thr Ile Pro Leu Ala Cys Lys Ile Phe Asn Ile Pro Cys
             340                 345                 350        
 Asp Asp Ile Arg Lys Ala Arg Gln His Met Glu Val Glu Leu Pro Tyr
         355                 360                 365            
 Arg Tyr Ile Thr Tyr Gly Met Val Gly Phe Ser Ile Thr Phe Phe Val
     370                 375                 380                
 Pro Tyr Ile Phe Phe Phe Ile Gly Ile Ser
 385                 390                



      <210> 1104
      <211> 336
      <212> PRT
      <213> Homo sapiens


      <400> 1104
 Met Arg Tyr Val Arg Leu Thr Leu Ser Gly Ile His Pro Arg Pro Ile
   1               5                  10                  15    
 Thr Gly Ser Pro Ser Pro Leu Lys Glu Ser Phe Gly Gly Cys Cys Val
              20                  25                  30        
 Ser Gly Leu Ile Ala Met Gly Thr Lys Ala Gln Val Glu Arg Lys Leu
          35                  40                  45            
 Leu Cys Leu Phe Ile Leu Ala Ile Leu Leu Cys Ser Leu Ala Leu Gly
      50                  55                  60                
 Ser Val Thr Val His Ser Ser Glu Pro Glu Val Arg Ile Pro Glu Asn
  65                  70                  75                  80
 Asn Pro Val Lys Leu Ser Cys Ala Tyr Ser Gly Phe Ser Ser Pro Arg
                  85                  90                  95    
 Val Glu Trp Lys Phe Asp Gln Gly Asp Thr Thr Arg Leu Val Cys Tyr
             100                 105                 110        
 Asn Asn Lys Ile Thr Ala Ser Tyr Glu Asp Arg Val Thr Phe Leu Pro
         115                 120                 125            
 Thr Gly Ile Thr Phe Lys Ser Val Thr Arg Glu Asp Thr Gly Thr Tyr
     130                 135                 140                
 Thr Cys Met Val Ser Glu Glu Gly Gly Asn Ser Tyr Gly Glu Val Lys
 145                 150                 155                 160
 Val Lys Leu Ile Val Leu Val Pro Pro Ser Lys Pro Thr Val Asn Ile
                 165                 170                 175    
 Pro Ser Ser Ala Thr Ile Gly Asn Arg Ala Val Leu Thr Cys Ser Glu
             180                 185                 190        
 Gln Asp Gly Ser Pro Pro Ser Glu Tyr Thr Trp Phe Lys Asp Gly Ile
         195                 200                 205            
 Val Met Pro Thr Asn Pro Lys Ser Thr Arg Ala Phe Ser Asn Ser Ser
     210                 215                 220                
 Tyr Val Leu Asn Pro Thr Thr Gly Glu Leu Val Phe Asp Pro Leu Ser
 225                 230                 235                 240
 Ala Ser Asp Thr Gly Glu Tyr Ser Cys Glu Ala Arg Asn Gly Tyr Gly
                 245                 250                 255    
 Thr Pro Met Thr Ser Asn Ala Val Arg Met Glu Ala Val Glu Arg Asn
             260                 265                 270        
 Val Gly Val Ile Val Ala Ala Val Leu Val Thr Leu Ile Leu Leu Gly
         275                 280                 285            
 Ile Leu Val Phe Gly Ile Trp Phe Ala Tyr Ser Arg Gly His Phe Asp
     290                 295                 300                
 Arg Thr Lys Lys Gly Thr Ser Ser Lys Lys Val Ile Tyr Ser Gln Pro
 305                 310                 315                 320
 Ser Ala Arg Ser Glu Gly Glu Phe Lys Gln Thr Ser Ser Phe Leu Val
                 325                 330                 335    





      <210> 1105
      <211> 137
      <212> PRT
      <213> Homo sapiens


      <400> 1105
 Met Gly Val Val Ala Val Glu Arg Lys Trp Val Ser Thr Thr Ile Lys
   1               5                  10                  15    
 Pro Leu Cys Ala Arg Pro Glu Leu Val Arg Thr Ala Cys Gln Ser Leu
              20                  25                  30        
 Val Ser Asp Thr Met Gly Thr Arg Leu Leu Pro Ala Leu Phe Leu Val
          35                  40                  45            
 Leu Leu Val Leu Gly Phe Glu Val Gln Gly Thr Gln Gln Pro Gln Gln
      50                  55                  60                
 Asp Glu Met Pro Ser Pro Thr Phe Leu Thr Gln Val Lys Glu Ser Leu
  65                  70                  75                  80
 Ser Ser Tyr Trp Glu Ser Ala Lys Thr Ala Ala Gln Asn Leu Tyr Glu
                  85                  90                  95    
 Lys Thr Tyr Leu Pro Ala Val Asp Glu Lys Leu Arg Asp Leu Tyr Ser
             100                 105                 110        
 Lys Ser Thr Ala Ala Met Ser Thr Tyr Thr Gly Ile Phe Thr Asp Gln
         115                 120                 125            
 Val Leu Ser Val Leu Lys Gly Glu Glu
     130                 135        



      <210> 1106
      <211> 208
      <212> PRT
      <213> Homo sapiens


      <400> 1106
 Met Ile Ile Tyr Arg Asp Leu Ile Ser His Asp Glu Met Phe Ser Asp
   1               5                  10                  15    
 Ile Tyr Lys Ile Arg Glu Ile Ala Asp Gly Leu Cys Leu Glu Val Glu
              20                  25                  30        
 Gly Lys Met Val Ser Arg Thr Glu Gly Asn Ile Asp Asp Ser Leu Ile
          35                  40                  45            
 Gly Gly Asn Ala Ser Ala Glu Gly Pro Glu Gly Glu Gly Thr Glu Ser
      50                  55                  60                
 Thr Val Ile Thr Gly Val Asp Ile Val Met Asn His His Leu Gln Glu
  65                  70                  75                  80
 Thr Ser Phe Thr Lys Glu Ala Tyr Lys Lys Tyr Ile Lys Asp Tyr Met
                  85                  90                  95    
 Lys Ser Ile Lys Gly Lys Leu Glu Glu Gln Arg Pro Glu Arg Val Lys
             100                 105                 110        
 Pro Phe Met Thr Gly Ala Ala Glu Gln Ile Lys His Ile Leu Ala Asn
         115                 120                 125            
 Phe Lys Asn Tyr Gln Phe Phe Ile Gly Glu Asn Met Asn Pro Asp Gly
     130                 135                 140                
 Met Val Ala Leu Leu Asp Tyr Arg Glu Gly Trp Cys Asp Pro Ile Tyr
 145                 150                 155                 160
 Asp Ser Ser Leu Arg Met Val Arg Thr Trp Thr Ser Cys Ser His Met
                 165                 170                 175    
 Trp His Leu Phe Gly Leu Leu Ser Pro Val Ile Ile Leu Val Leu Leu
             180                 185                 190        
 Val Ile His Thr Asn Thr Gly Leu Arg Pro His Gly Thr Asp Val Ile
         195                 200                 205            





      <210> 1107
      <211> 812
      <212> PRT
      <213> Homo sapiens


      <400> 1107
 Met Gly Ala Gly Pro Arg Gly Met Val Phe Ser Trp Val Pro Arg Val
   1               5                  10                  15    
 Arg Asp Ile Leu Ile Val Tyr Ser Pro Asp Ala Glu Glu Trp Cys Gln
              20                  25                  30        
 Tyr Leu Gln Thr Leu Phe Leu Ser Ser Arg Gln Val Arg Ser Gln Lys
          35                  40                  45            
 Ile Leu Thr His Arg Leu Gly Pro Glu Ala Ser Phe Ser Ala Glu Asp
      50                  55                  60                
 Leu Ser Leu Phe Leu Ser Thr Arg Cys Val Val Val Leu Leu Ser Ala
  65                  70                  75                  80
 Glu Leu Val Gln His Phe His Lys Pro Ser Leu Leu Pro Leu Leu Gln
                  85                  90                  95    
 Arg Ala Phe His Pro Pro His Arg Val Val Arg Leu Leu Cys Gly Val
             100                 105                 110        
 Arg Asp Ser Glu Glu Phe Leu Asp Phe Phe Pro Asp Trp Ala His Trp
         115                 120                 125            
 Gln Glu Leu Thr Cys Asp Asp Glu Pro Glu Thr Tyr Val Ala Ala Val
     130                 135                 140                
 Lys Lys Ala Ile Ser Glu Asp Ser Gly Cys Asp Ser Val Thr Asp Thr
 145                 150                 155                 160
 Glu Pro Glu Asp Glu Lys Val Val Ser Tyr Ser Lys Gln Gln Asn Leu
                 165                 170                 175    
 Pro Thr Val Thr Ser Pro Gly Asn Leu Met Val Val Gln Pro Asp Arg
             180                 185                 190        
 Ile Arg Cys Gly Ala Glu Thr Thr Val Tyr Val Ile Val Arg Cys Lys
         195                 200                 205            
 Leu Asp Asp Arg Val Ala Thr Glu Ala Glu Phe Ser Pro Glu Asp Ser
     210                 215                 220                
 Pro Ser Val Arg Met Glu Ala Lys Val Glu Asn Glu Tyr Thr Ile Ser
 225                 230                 235                 240
 Val Lys Ala Pro Asn Leu Ser Ser Gly Asn Val Ser Leu Lys Ile Tyr
                 245                 250                 255    
 Ser Gly Asp Leu Val Val Cys Glu Thr Val Ile Ser Tyr Tyr Thr Asp
             260                 265                 270        
 Met Glu Glu Ile Gly Asn Leu Leu Ser Asn Ala Ala Asn Pro Val Glu
         275                 280                 285            
 Phe Met Cys Gln Ala Phe Lys Ile Val Pro Tyr Asn Thr Glu Thr Leu
     290                 295                 300                
 Asp Lys Leu Leu Thr Glu Ser Leu Lys Asn Asn Ile Pro Ala Ser Gly
 305                 310                 315                 320
 Leu His Leu Phe Gly Ile Asn Gln Leu Glu Glu Glu Asp Met Met Thr
                 325                 330                 335    
 Asn Gln Arg Asp Glu Glu Leu Pro Thr Leu Leu His Phe Ala Ala Lys
             340                 345                 350        
 Tyr Gly Leu Lys Asn Leu Thr Ala Leu Leu Leu Thr Cys Pro Gly Ala
         355                 360                 365            
 Leu Gln Ala Tyr Ser Val Ala Asn Lys His Gly His Tyr Pro Asn Thr
     370                 375                 380                
 Ile Ala Glu Lys His Gly Phe Arg Asp Leu Arg Gln Phe Ile Asp Glu
 385                 390                 395                 400
 Tyr Val Glu Thr Val Asp Met Leu Lys Ser His Ile Lys Glu Glu Leu
                 405                 410                 415    
 Met His Gly Glu Glu Ala Asp Ala Val Tyr Glu Ser Met Ala His Leu
             420                 425                 430        
 Ser Thr Asp Leu Leu Met Lys Cys Ser Leu Asn Pro Gly Cys Asp Glu
         435                 440                 445            
 Asp Leu Tyr Glu Ser Met Ala Ala Phe Val Pro Ala Ala Thr Glu Asp
     450                 455                 460                
 Leu Tyr Val Glu Met Leu Gln Ala Ser Thr Ser Asn Pro Ile Pro Gly
 465                 470                 475                 480
 Asp Gly Phe Ser Arg Ala Thr Lys Asp Ser Met Ile Arg Lys Phe Leu
                 485                 490                 495    
 Glu Gly Asn Ser Met Gly Met Thr Asn Leu Glu Arg Asp Gln Cys His
             500                 505                 510        
 Leu Gly Gln Glu Glu Asp Val Tyr His Thr Val Asp Asp Asp Glu Ala
         515                 520                 525            
 Phe Ser Val Asp Leu Ala Ser Arg Pro Pro Val Pro Val Pro Arg Pro
     530                 535                 540                
 Glu Thr Thr Ala Pro Gly Ala His Gln Leu Pro Asp Asn Glu Pro Tyr
 545                 550                 555                 560
 Ile Phe Lys Val Phe Ala Glu Lys Ser Gln Glu Arg Pro Gly Asn Phe
                 565                 570                 575    
 Tyr Val Ser Ser Glu Ser Ile Arg Lys Gly Pro Pro Val Arg Pro Trp
             580                 585                 590        
 Arg Asp Arg Pro Gln Ser Ser Ile Tyr Asp Pro Phe Ala Gly Met Lys
         595                 600                 605            
 Thr Pro Gly Gln Arg Gln Leu Ile Thr Leu Gln Glu Gln Val Lys Leu
     610                 615                 620                
 Gly Ile Val Asn Val Asp Glu Ala Val Leu His Phe Lys Glu Trp Gln
 625                 630                 635                 640
 Leu Asn Gln Lys Lys Arg Ser Glu Ser Phe Arg Phe Gln Gln Glu Asn
                 645                 650                 655    
 Leu Lys Arg Leu Arg Asp Ser Ile Thr Arg Arg Gln Arg Glu Lys Gln
             660                 665                 670        
 Lys Ser Gly Lys Gln Thr Asp Leu Glu Ile Thr Val Pro Ile Arg His
         675                 680                 685            
 Ser Gln His Leu Pro Ala Lys Val Glu Phe Gly Val Tyr Glu Ser Gly
     690                 695                 700                
 Pro Arg Lys Ser Val Ile Pro Pro Arg Thr Glu Leu Arg Arg Gly Asp
 705                 710                 715                 720
 Trp Lys Thr Asp Ser Thr Ser Ser Thr Ala Ser Ser Thr Ser Asn Arg
                 725                 730                 735    
 Ser Ser Thr Arg Ser Leu Leu Ser Val Ser Ser Gly Met Glu Gly Asp
             740                 745                 750        
 Asn Glu Asp Asn Glu Val Pro Glu Val Thr Arg Ser Arg Ser Pro Gly
         755                 760                 765            
 Pro Pro Gln Val Asp Gly Thr Pro Thr Met Ser Leu Glu Arg Pro Pro
     770                 775                 780                
 Arg Val Pro Pro Arg Ala Ala Ser Gln Arg Pro Pro Thr Arg Glu Thr
 785                 790                 795                 800
 Phe His Pro Pro Pro Pro Val Pro Pro Arg Gly Arg
                 805                 810        



      <210> 1108
      <211> 276
      <212> PRT
      <213> Homo sapiens


      <400> 1108
 Met Trp Gly Cys Lys Met Cys Phe Gly Ile Leu Gly Lys Lys Glu Cys
   1               5                  10                  15    
 Tyr Ile Asn Ser Cys Phe Gln Glu Ile Met Lys Lys Thr Ser Ile Tyr
              20                  25                  30        
 His Leu Pro Ser Phe His Tyr Leu Met Asp Ser Glu Ala Gln Glu Asp
          35                  40                  45            
 Thr Arg Glu Ala Tyr Asp Asp Lys Gln Val Val Thr Glu Ile Met Ala
      50                  55                  60                
 Arg Cys Phe Ile Pro Thr Leu Ile Thr Thr Thr Ser Trp Glu Ser Phe
  65                  70                  75                  80
 His Phe Ile Gly His Glu Ile Arg Ile Thr Glu Ala Met Asp Cys Tyr
                  85                  90                  95    
 Gly Ala Val Val Trp Pro Ser Ala Leu Val Leu Cys Tyr Phe Leu Glu
             100                 105                 110        
 Thr Asn Ala Lys Gln Tyr Asn Met Val Asp Lys Asn Val Ile Glu Ile
         115                 120                 125            
 Gly Ala Gly Thr Gly Leu Val Ser Ile Val Ala Ser Leu Leu Gly Ala
     130                 135                 140                
 His Val Thr Ala Thr Asp Leu Pro Glu Leu Leu Gly Asn Leu Gln Tyr
 145                 150                 155                 160
 Asn Ile Ser Arg Asn Thr Lys Met Lys Ser Lys His Leu Pro Gln Val
                 165                 170                 175    
 Lys Glu Leu Ser Trp Gly Val Ala Leu Asp Thr Asn Phe Pro Arg Ser
             180                 185                 190        
 Ser Asn Asn Phe Asp Tyr Ile Leu Ala Ala Asp Val Val Tyr Ala His
         195                 200                 205            
 Pro Phe Leu Glu Glu Leu Leu Ile Thr Phe Asp His Leu Cys Lys Glu
     210                 215                 220                
 Thr Thr Ile Ile Leu Trp Ala Met Lys Phe Arg Leu Glu Lys Glu Asn
 225                 230                 235                 240
 Lys Phe Val Asp Arg Phe Lys Glu Leu Phe Asp Leu Glu Glu Ile Ser
                 245                 250                 255    
 Ser Phe Pro Ser Leu Asn Ile Lys Leu Tyr Lys Ala Val Lys Lys Asn
             260                 265                 270        
 Arg Arg Ser Val
         275    



      <210> 1109
      <211> 237
      <212> PRT
      <213> Homo sapiens


      <400> 1109
 Met Ser Ser Lys Lys Ala Lys Thr Lys Thr Thr Lys Lys Arg Pro Gln
   1               5                  10                  15    
 Arg Ala Thr Ser Asn Val Phe Ala Met Phe Asp Gln Ser Gln Ile Gln
              20                  25                  30        
 Glu Phe Lys Glu Ala Phe Asn Met Ile Asp Gln Asn Arg Asp Gly Phe
          35                  40                  45            
 Ile Asp Lys Glu Asp Leu His Asp Met Leu Ala Ser Leu Gly Lys Asn
      50                  55                  60                
 Pro Thr Asp Ala Tyr Leu Asp Ala Met Met Asn Glu Ala Pro Gly Pro
  65                  70                  75                  80
 Ile Asn Phe Thr Met Phe Leu Thr Met Phe Gly Glu Lys Leu Asn Gly
                  85                  90                  95    
 Thr Asp Pro Glu Asp Val Ile Arg Asn Ala Phe Ala Cys Phe Asp Glu
             100                 105                 110        
 Glu Ala Thr Gly Thr Ile Gln Glu Asp Tyr Leu Arg Glu Leu Leu Thr
         115                 120                 125            
 Thr Met Gly Asp Arg Phe Thr Asp Glu Glu Val Asp Glu Leu Tyr Arg
     130                 135                 140                
 Glu Ala Pro Ile Asp Lys Lys Gly Asn Phe Asn Tyr Ile Glu Phe Thr
 145                 150                 155                 160
 Arg Ile Leu Lys His Gly Ala Lys Thr Lys Met Thr Glu Arg Thr Leu
                 165                 170                 175    
 Ala Lys Ile Phe Gln Leu His Cys Leu Thr Leu Phe Tyr Phe Ser Asp
             180                 185                 190        
 Thr Ser Pro Thr Leu Ile Glu Pro Val Ala Cys Asn Leu Val Ser Gln
         195                 200                 205            
 Leu Cys Leu Phe Phe Leu Met Tyr Leu Phe Gln Thr Phe Leu Pro Leu
     210                 215                 220                
 Ser Thr Cys Ile Ile Arg Leu Glu Met Gly Met Arg Val
 225                 230                 235        



      <210> 1110
      <211> 160
      <212> PRT
      <213> Homo sapiens


      <400> 1110
 Met Glu Gly Trp Gly Gly Gly Gly Thr His Arg Cys Val Ser Glu Arg
   1               5                  10                  15    
 Ser Pro Leu Arg Ala Phe Leu Glu Met Glu Pro Ile Ser Leu Ser Ser
              20                  25                  30        
 Met Lys Gly Gly Leu Pro Gly Pro Pro Leu Ala Ala Gly Pro Pro Thr
          35                  40                  45            
 Pro Gly Leu Pro Pro Ala Pro Pro His Ile Gly Pro Ser Cys Phe Gln
      50                  55                  60                
 Leu Leu Gln Arg Ala Phe Ala Ala Lys Ala Ser Ser Ser Pro Leu Leu
  65                  70                  75                  80
 Arg Pro Ser Met Ala Thr Pro Thr Gln Thr Pro Thr Lys Ala Pro Glu
                  85                  90                  95    
 Glu Pro Asp Pro Phe Tyr Tyr Asp Tyr Asn Thr Val Gln Thr Val Gly
             100                 105                 110        
 Met Thr Leu Ala Thr Ile Leu Phe Leu Leu Gly Ile Leu Ile Val Ile
         115                 120                 125            
 Ser Lys Lys Val Lys Cys Arg Lys Ala Asp Ser Ser Pro Thr Cys Lys
     130                 135                 140                
 Ser Cys Lys Ser Glu Leu Pro Ser Ser Ala Pro Gly Gly Gly Gly Val
 145                 150                 155                 160





      <210> 1111
      <211> 417
      <212> PRT
      <213> Homo sapiens


      <400> 1111
 Met Asn Trp Ala Ala Phe Gly Gly Ser Glu Phe Phe Ile Pro Glu Gly
   1               5                  10                  15    
 Ile Gln Ile Asp Ser Arg Cys Pro Leu Ser Arg Asn Ile Thr Glu Trp
              20                  25                  30        
 Tyr His Tyr Tyr Gly Ile Ala Val Lys Glu Ser Ser Gln Tyr Tyr Asp
          35                  40                  45            
 Val Met Tyr Ser Lys Lys Gly Ala Ala Trp Val Ser Glu Thr Gly Lys
      50                  55                  60                
 Lys Glu Val Ser Lys Gln Thr Val Ala Tyr Ser Pro Arg Ser Lys Leu
  65                  70                  75                  80
 Gly Thr Leu Leu Pro Glu Phe Pro Asn Val Lys Asp Leu Asn Leu Pro
                  85                  90                  95    
 Ala Ser Leu Pro Glu Glu Lys Val Ser Thr Phe Ile Met Met Tyr Arg
             100                 105                 110        
 Thr His Cys Gln Arg Ile Leu Asp Thr Val Ile Arg Ala Asn Phe Asp
         115                 120                 125            
 Glu Val Gln Ser Phe Leu Leu His Phe Trp Gln Gly Met Pro Pro His
     130                 135                 140                
 Met Leu Pro Val Leu Gly Ser Ser Thr Val Val Asn Ile Val Gly Val
 145                 150                 155                 160
 Cys Asp Ser Ile Leu Tyr Lys Ala Ile Ser Gly Val Leu Met Pro Thr
                 165                 170                 175    
 Val Leu Gln Ala Leu Pro Asp Ser Leu Thr Gln Val Ile Arg Lys Phe
             180                 185                 190        
 Ala Lys Gln Leu Asp Glu Trp Leu Lys Val Ala Leu His Asp Leu Pro
         195                 200                 205            
 Glu Asn Leu Arg Asn Ile Lys Phe Glu Tyr Glu Ala Leu Arg Gly Lys
     210                 215                 220                
 Glu Ser Ser Pro Lys Ala Ala Pro Pro His Ile Ser Lys Ser Ser Leu
 225                 230                 235                 240
 Pro Gly Ile Ser Asn Arg Ile His Ser Ala Asp Ile Thr Phe Gln Met
                 245                 250                 255    
 Leu Glu Asp Trp Arg Asn Val Asp Leu Asn Ser Ile Thr Lys Gln Thr
             260                 265                 270        
 Leu Tyr Thr Met Glu Asp Ser Arg Asp Glu His Arg Lys Leu Ile Thr
         275                 280                 285            
 Gln Tyr Val Ala Leu Val Lys Tyr Asn Cys Ser Asp Ala Cys Gly Val
     290                 295                 300                
 Leu Leu Cys Leu Thr Val Tyr Gln Glu Phe Asp His Leu Leu Glu Glu
 305                 310                 315                 320
 Gln Ser Pro Ile Glu Ser Tyr Ile Glu Trp Leu Asp Thr Met Val Asp
                 325                 330                 335    
 Arg Cys Val Val Lys Val Gly Gly Cys Gln Glu Thr Arg Val Leu Glu
             340                 345                 350        
 Glu Ser Gly Pro Ala Val Pro Leu Asp Val Val Leu Phe Arg His Lys
         355                 360                 365            
 Gly Asp Pro Gly His Asp Leu Ala Gln Arg Pro Gln Leu Arg Leu Ser
     370                 375                 380                
 Val Ser Pro Phe His Phe Pro Val Phe Ile Asp Ile His Tyr Pro His
 385                 390                 395                 400
 Arg Cys Asp Thr Leu Ala Met Asn Cys Leu Leu Pro Asn Asn Leu Asn
                 405                 410                 415    
 Asp
    



      <210> 1112
      <211> 358
      <212> PRT
      <213> Homo sapiens


      <400> 1112
 Met Gly Gly Ser Glu Gly Ile Val Glu Ser Ile Gln Ile Met Lys Glu
   1               5                  10                  15    
 Gly Lys Ala Thr Ala Ser Glu Ala Val Asp Cys Lys Trp Tyr Ile Arg
              20                  25                  30        
 Ala Pro Pro Arg Ser Lys Ile Tyr Leu Arg Phe Leu Asp Tyr Glu Met
          35                  40                  45            
 Gln Asn Ser Asn Glu Cys Lys Arg Asn Phe Val Ala Val Tyr Asp Gly
      50                  55                  60                
 Ser Ser Ser Val Glu Asp Leu Lys Ala Lys Phe Cys Ser Thr Val Ala
  65                  70                  75                  80
 Asn Asp Val Met Leu Arg Thr Gly Leu Gly Val Ile Arg Met Trp Ala
                  85                  90                  95    
 Asp Glu Gly Ser Arg Asn Ser Arg Phe Gln Met Leu Phe Thr Ser Phe
             100                 105                 110        
 Gln Glu Pro Pro Cys Glu Gly Asn Thr Phe Phe Cys His Ser Asn Met
         115                 120                 125            
 Cys Ile Asn Asn Thr Leu Val Cys Asn Gly Leu Gln Asn Cys Val Tyr
     130                 135                 140                
 Pro Trp Asp Glu Asn His Cys Lys Glu Lys Arg Lys Thr Ser Leu Leu
 145                 150                 155                 160
 Asp Gln Leu Thr Asn Thr Ser Gly Thr Val Ile Gly Val Thr Ser Cys
                 165                 170                 175    
 Ile Gly Ile Ile Leu Ile Ile Ile Ser Val Ile Val Gln Ile Lys Gln
             180                 185                 190        
 Pro Arg Lys Lys Tyr Val Gln Arg Lys Ser Asp Phe Asp Gln Thr Val
         195                 200                 205            
 Phe Gln Glu Val Phe Glu Pro Pro His Tyr Glu Leu Cys Thr Leu Arg
     210                 215                 220                
 Gly Thr Gly Ala Thr Ala Asp Phe Ala Asp Val Ala Asp Asp Phe Glu
 225                 230                 235                 240
 Asn Tyr His Lys Leu Arg Arg Ser Ser Ser Lys Cys Ile His Asp His
                 245                 250                 255    
 His Cys Gly Ser Gln Leu Ser Ser Thr Lys Gly Ser Arg Ser Asn Leu
             260                 265                 270        
 Ser Thr Arg Asp Ala Ser Ile Leu Thr Glu Met Pro Thr Gln Pro Gly
         275                 280                 285            
 Lys Pro Leu Ile Pro Pro Met Asn Arg Arg Asn Ile Leu Val Met Lys
     290                 295                 300                
 His Asn Tyr Ser Gln Asp Ala Ala Asp Ala Cys Asp Ile Asp Glu Ile
 305                 310                 315                 320
 Glu Glu Val Pro Thr Thr Ser His Arg Leu Ser Arg His Asp Lys Ala
                 325                 330                 335    
 Val Gln Arg Phe Cys Leu Ile Gly Ser Leu Ser Lys His Glu Ser Glu
             340                 345                 350        
 Tyr Asn Thr Thr Arg Val
         355            



      <210> 1113
      <211> 178
      <212> PRT
      <213> Homo sapiens


      <400> 1113
 Met Leu Ser Ala Arg Asp Arg Arg Asp Arg His Pro Glu Glu Gly Val
   1               5                  10                  15    
 Val Ala Glu Leu Gln Gly Phe Ala Val Asp Lys Ala Phe Leu Thr Ser
              20                  25                  30        
 His Lys Gly Ile Leu Leu Glu Thr Glu Leu Ala Leu Thr Leu Ile Ile
          35                  40                  45            
 Phe Ile Cys Phe Thr Ala Ser Ile Ser Ala Tyr Met Ala Ala Ala Leu
      50                  55                  60                
 Leu Glu Phe Phe Ile Thr Leu Ala Phe Leu Phe Leu Tyr Ala Thr Gln
  65                  70                  75                  80
 Tyr Tyr Gln Arg Phe Asp Arg Ile Asn Trp Pro Cys Leu Asp Phe Leu
                  85                  90                  95    
 Arg Cys Val Ser Ala Ile Ile Ile Phe Leu Val Val Ser Phe Ala Ala
             100                 105                 110        
 Val Thr Ser Arg Asp Gly Ala Ala Ile Ala Ala Phe Val Phe Gly Ile
         115                 120                 125            
 Ile Leu Val Ser Ile Phe Ala Tyr Asp Ala Phe Lys Ile Tyr Arg Thr
     130                 135                 140                
 Glu Met Ala Pro Gly Ala Ala Arg Gly Thr Ser Ser Asp Ser Gly Ala
 145                 150                 155                 160
 Asn Trp Leu Leu Ser Pro Ala Ala Glu Arg Lys Val Glu Pro Arg His
                 165                 170                 175    
 Val Ser
        



      <210> 1114
      <211> 107
      <212> PRT
      <213> Homo sapiens


      <400> 1114
 Met Ala Ser Gly Ala Ala Arg Trp Leu Val Leu Ala Pro Asp Arg Ser
   1               5                  10                  15    
 Gly Ala Leu Gln Thr Gly Pro Ser Leu Arg Lys His Gly Asp Val Ser
              20                  25                  30        
 Ala Ala Trp Ser Gly Ser Ser Arg Ser Leu Val Pro Val Arg Ser Tyr
          35                  40                  45            
 Ile Val Thr Arg Ser Gly Ala Ile Leu Pro Lys Pro Gly Lys Thr Asp
      50                  55                  60                
 Ile Gly Leu Leu Arg Val Phe Ser Ile Val Ile Pro Phe Leu Tyr Val
  65                  70                  75                  80
 Gly Thr Leu Ile Ser Lys Asn Phe Ala Ala Leu Leu Glu Glu His Asp
                  85                  90                  95    
 Ile Phe Val Pro Glu Asp Asp Asp Asp Asp Asp
             100                 105        



      <210> 1115
      <211> 349
      <212> PRT
      <213> Homo sapiens


      <400> 1115
 Met Ala Glu Met Thr Glu Val Glu Phe Arg Ile Trp Ile Gly Thr Lys
   1               5                  10                  15    
 Ile Ile Lys Ile Gln Glu Lys Val Lys Thr Gln Ser Lys Glu Ser Lys
              20                  25                  30        
 Glu Tyr His Lys Met Ile Gln Glu Leu Lys Asp Glu Met Ala Ile Leu
          35                  40                  45            
 Arg Lys Asn Gln Thr Asp Leu Ile Glu Leu Lys Asn Ser Leu Tyr Glu
      50                  55                  60                
 Phe His Asn Thr Ile Thr Ser Val Ser Ser Arg Ile Asp Gln Thr Glu
  65                  70                  75                  80
 Glu Arg Ile Ser Glu Leu Glu Asp Trp Phe Ser Lys Val Leu Ala Met
                  85                  90                  95    
 Gly Asp Lys Gly Thr Gly Asn His Ser Asp Val Thr Asp Phe Ile Leu
             100                 105                 110        
 Glu Gly Phe Arg Val Arg Pro Glu Phe Tyr Ile Leu Leu Phe Phe Leu
         115                 120                 125            
 Phe Leu Leu Ile Tyr Ser Met Val Leu Leu Gly Asn Ile Ser Val Met
     130                 135                 140                
 Thr Ile Ile Val Thr Asp Ser Gln Leu Asn Thr Pro Met Tyr Phe Phe
 145                 150                 155                 160
 Leu Gly Asn Leu Ser Phe Ile Asp Val Ser Tyr Ser Thr Val Ile Ala
                 165                 170                 175    
 Pro Lys Ala Met Ala His Phe Leu Ser Glu Lys Lys Thr Val Ser Phe
             180                 185                 190        
 Ala Gly Cys Val Ala Gln Leu Phe Leu Phe Ala Leu Phe Ile Val Thr
         195                 200                 205            
 Glu Gly Phe Val Leu Ala Ala Met Ala Tyr Asp Arg Phe Ser Ala Ile
     210                 215                 220                
 Cys Asn Pro Leu Leu His Ser Val His Met Ser Arg Arg Leu Cys Thr
 225                 230                 235                 240
 Gln Leu Val Ala Gly Ser Tyr Phe Cys Gly Trp Ala Ser Ser Ile Leu
                 245                 250                 255    
 Gln Val Ser Val Thr Phe Ser Val Ser Phe Cys Ala Ser Arg Val Ile
             260                 265                 270        
 Ala His Phe Tyr Cys Asp Ser Tyr Gln Ile Glu Lys Ile Ser Cys Ser
         275                 280                 285            
 Asn Leu Phe Val Asn Lys Met Val Ser Leu Ser Leu Ser Val Ile Ile
     290                 295                 300                
 Ile Leu Pro Thr Ile Val Val Ile Ile Val Ser Tyr Leu Tyr Ile Val
 305                 310                 315                 320
 Ser Ser Val Leu Lys Ile Pro Ser Ser Glu Gly Arg Lys Lys Asp Phe
                 325                 330                 335    
 Ser Thr Cys Ser Ser His Arg Gly Val Val Ser Leu Leu
             340                 345                



      <210> 1116
      <211> 384
      <212> PRT
      <213> Homo sapiens


      <400> 1116
 Met Leu Thr Ser Met Ala Tyr Asp Cys Cys Val Ala Ile Cys Tyr Pro
   1               5                  10                  15    
 Leu Leu Tyr Asn Ile Ala Met Ser Pro Lys Val Cys Ser Ser His Met
              20                  25                  30        
 Leu Gly Ser Tyr Phe Trp Pro Phe Ser Gly Ala Met Ala His Thr Arg
          35                  40                  45            
 Cys Met Leu Lys Leu Thr Ser Cys Glu Ala Asn Thr Ile Asn His Tyr
      50                  55                  60                
 Phe Arg Asp Thr Leu His Val Phe Gln Leu Ser Cys Thr Ser Thr Tyr
  65                  70                  75                  80
 Ile Arg Ala Glu Phe Ile Leu Ala Gly Leu Thr Gln Arg Pro Glu Leu
                  85                  90                  95    
 Gln Leu Pro Leu Phe Leu Leu Phe Leu Gly Ile Tyr Val Val Thr Val
             100                 105                 110        
 Val Gly Asn Leu Gly Met Ile Phe Leu Ile Ala Leu Ser Ser Gln Leu
         115                 120                 125            
 Tyr Pro Pro Val Tyr Tyr Phe Leu Ser His Leu Ser Phe Ile Asp Leu
     130                 135                 140                
 Cys Tyr Ser Ser Val Ile Thr Pro Lys Met Leu Val Asn Phe Val Pro
 145                 150                 155                 160
 Glu Glu Asn Ile Ile Ser Phe Leu Glu Cys Ile Thr Gln Leu Tyr Phe
                 165                 170                 175    
 Phe Leu Ile Phe Val Ile Ala Glu Gly Tyr Leu Leu Thr Ala Met Glu
             180                 185                 190        
 Tyr Asp Arg Tyr Val Ala Ile Cys Arg Pro Leu Leu Tyr Asn Ile Val
         195                 200                 205            
 Met Ser His Arg Val Cys Ser Ile Met Met Ala Val Val Tyr Ser Leu
     210                 215                 220                
 Gly Phe Leu Trp Ala Thr Val His Thr Thr Arg Met Ser Val Leu Ser
 225                 230                 235                 240
 Phe Cys Arg Ser His Thr Val Ser His Tyr Phe Cys Asp Ile Leu Pro
                 245                 250                 255    
 Leu Leu Thr Leu Ser Cys Ser Ser Thr His Ile Asn Glu Ile Leu Leu
             260                 265                 270        
 Phe Ile Ile Gly Gly Val Asn Thr Leu Ala Thr Thr Leu Ala Val Leu
         275                 280                 285            
 Ile Ser Tyr Ala Phe Ile Phe Ser Ser Ile Leu Gly Ile His Ser Thr
     290                 295                 300                
 Glu Gly Gln Ser Lys Ala Phe Gly Thr Cys Ser Ser His Leu Leu Ala
 305                 310                 315                 320
 Val Gly Ile Phe Phe Gly Ser Ile Thr Phe Met Tyr Phe Lys Pro Pro
                 325                 330                 335    
 Ser Ser Thr Thr Met Glu Lys Glu Lys Val Ser Ser Val Phe Tyr Ile
             340                 345                 350        
 Thr Ile Ile Pro Met Leu Asn Pro Leu Ile Tyr Ser Leu Arg Asn Lys
         355                 360                 365            
 Asp Val Lys Asn Ala Leu Lys Lys Met Thr Arg Gly Arg Gln Ser Ser
     370                 375                 380                





      <210> 1117
      <211> 122
      <212> PRT
      <213> Homo sapiens


      <400> 1117
 Met Asn Pro Ser Glu Met Gln Arg Lys Val Pro Pro Gln Arg Gln Lys
   1               5                  10                  15    
 Thr Cys Asn Arg Ala Ser Ser Thr Arg Gln Val Asn Lys Met Val Ile
              20                  25                  30        
 Ser Glu Glu Gln Met Lys Leu Pro Ser Thr Lys Glu Ala Glu Leu Pro
          35                  40                  45            
 Thr Trp Ala Gln Leu Lys Lys Leu Thr Gln Leu Ala Glu Lys Ser Leu
      50                  55                  60                
 Lys Lys Thr Arg Val Thr Gln Thr Pro Glu Asn Met Leu Leu Ala Val
  65                  70                  75                  80
 Leu Met Ile Val Ser Thr Val Val Ser Leu Pro Met Ser Ala Gly Ala
                  85                  90                  95    
 Ala Ala Ala Asn Tyr Thr Tyr Trp Ala Tyr Val Pro Phe Leu Leu Leu
             100                 105                 110        
 Ile Trp Ala Val Ile Trp Met Asp Asn His
         115                 120        



      <210> 1118
      <211> 101
      <212> PRT
      <213> Homo sapiens


      <400> 1118
 Met Glu Arg Pro Asp Lys Ala Ala Leu Asn Ala Leu Gln Pro Pro Glu
   1               5                  10                  15    
 Phe Arg Asn Glu Ser Ser Leu Ala Ser Thr Leu Lys Thr Leu Leu Phe
              20                  25                  30        
 Phe Thr Ala Leu Met Ile Thr Val Pro Ile Gly Leu Tyr Phe Thr Thr
          35                  40                  45            
 Lys Ser Tyr Ile Phe Glu Gly Ala Leu Gly Met Ser Asn Arg Asp Ser
      50                  55                  60                
 Tyr Phe Tyr Ala Ala Ile Val Ala Val Val Ala Val His Val Val Leu
  65                  70                  75                  80
 Ala Leu Phe Val Tyr Val Ala Trp Asn Glu Gly Ser Arg Gln Trp Arg
                  85                  90                  95    
 Glu Gly Lys Gln Asp
             100    



      <210> 1119
      <211> 1574
      <212> PRT
      <213> Homo sapiens


      <400> 1119
 Met Val Glu Ala Lys Gly Lys Ala Arg Lys Pro His Gly Pro Trp Gly
   1               5                  10                  15    
 Arg Cys Thr Gly Asp Cys Gly Pro Gly Gly Val Gln Ser Arg Ala Val
              20                  25                  30        
 Trp Cys Phe His Val Asp Gly Trp Thr Ser His Leu Ser Asn Cys Gly
          35                  40                  45            
 Glu Ser Asn Arg Pro Pro Lys Glu Arg Ser Cys Phe Arg Val Cys Asp
      50                  55                  60                
 Trp His Ser Asp Leu Phe Gln Trp Glu Val Ser Asp Trp His His Cys
  65                  70                  75                  80
 Val Leu Val Pro Tyr Ala Arg Gly Glu Val Lys Pro Arg Thr Ala Glu
                  85                  90                  95    
 Cys Val Thr Ala Gln His Gly Leu Gln His Arg Met Val Arg Cys Ile
             100                 105                 110        
 Gln Lys Leu Asn Arg Thr Val Val Ala Asn Glu Ile Cys Glu His Phe
         115                 120                 125            
 Ala Leu Gln Pro Pro Thr Glu Gln Ala Cys Leu Ile Pro Cys Pro Arg
     130                 135                 140                
 Asp Cys Val Val Ser Glu Phe Leu Pro Trp Ser Asn Cys Ser Lys Gly
 145                 150                 155                 160
 Cys Gly Lys Lys Leu Gln His Arg Thr Arg Ala Val Ile Ala Pro Pro
                 165                 170                 175    
 Leu Phe Gly Gly Leu Gln Cys Pro Asn Leu Thr Glu Ser Arg Ala Cys
             180                 185                 190        
 Asp Ala Pro Ile Ser Cys Pro Leu Gly Glu Glu Glu Tyr Thr Phe Ser
         195                 200                 205            
 Leu Lys Val Gly Pro Trp Ser Lys Cys Arg Leu Pro His Leu Lys Glu
     210                 215                 220                
 Ile Asn Pro Ser Gly Arg Thr Val Leu Asp Phe Asn Ser Asp Ser Asn
 225                 230                 235                 240
 Glu Arg Val Thr Phe Lys His Gln Ser Tyr Lys Ala His His His Ser
                 245                 250                 255    
 Lys Ser Trp Ala Ile Glu Ile Gly Tyr Gln Thr Arg Gln Val Ser Cys
             260                 265                 270        
 Thr Arg Ser Asp Gly Gln Asn Ala Met Leu Ser Leu Cys Leu Gln Asp
         275                 280                 285            
 Ser Phe Pro Leu Thr Val Gln Ser Cys Ile Met Pro Lys Asp Cys Glu
     290                 295                 300                
 Thr Ser Gln Trp Ser Ser Trp Ser Pro Cys Ser Lys Thr Cys Arg Ser
 305                 310                 315                 320
 Gly Ser Leu Leu Pro Gly Phe Arg Ser Arg Ser Arg Asn Val Lys His
                 325                 330                 335    
 Met Ala Ile Gly Gly Gly Lys Glu Cys Pro Glu Leu Leu Glu Lys Glu
             340                 345                 350        
 Ala Cys Ile Val Glu Gly Glu Leu Leu Gln Gln Cys Pro Arg Tyr Ser
         355                 360                 365            
 Trp Arg Thr Ser Glu Trp Lys Glu Cys Gln Val Ser Leu Leu Leu Glu
     370                 375                 380                
 Gln Gln Asp Pro His Trp His Val Thr Gly Pro Val Cys Gly Gly Gly
 385                 390                 395                 400
 Ile Gln Thr Arg Glu Val Tyr Cys Ala Gln Ser Val Pro Ala Ala Ala
                 405                 410                 415    
 Ala Leu Arg Ala Lys Glu Val Ser Arg Pro Val Glu Lys Ala Leu Cys
             420                 425                 430        
 Val Gly Pro Ala Pro Leu Pro Ser Gln Leu Cys Asn Ile Pro Cys Ser
         435                 440                 445            
 Thr Asp Cys Ile Val Ser Ser Trp Ser Ala Trp Gly Leu Cys Ile His
     450                 455                 460                
 Glu Asn Cys His Glu Pro Gln Gly Lys Lys Gly Phe Arg Thr Arg Gln
 465                 470                 475                 480
 Arg His Val Leu Met Glu Ser Thr Gly Pro Ala Gly His Cys Pro His
                 485                 490                 495    
 Leu Val Glu Ser Val Pro Cys Glu Asp Pro Met Cys Tyr Arg Trp Leu
             500                 505                 510        
 Ala Ser Glu Gly Ile Cys Phe Pro Asp His Gly Lys Cys Gly Leu Gly
         515                 520                 525            
 His Arg Ile Leu Lys Ala Val Cys Gln Asn Asp Arg Gly Glu Asp Val
     530                 535                 540                
 Ser Gly Ser Leu Cys Pro Val Pro Pro Pro Pro Glu Arg Lys Ser Cys
 545                 550                 555                 560
 Glu Ile Pro Cys Arg Met Asp Cys Val Leu Ser Glu Trp Thr Glu Trp
                 565                 570                 575    
 Ser Ser Cys Ser Gln Ser Cys Ser Asn Lys Asn Ser Asp Gly Lys Gln
             580                 585                 590        
 Thr Arg Ser Arg Thr Ile Leu Ala Leu Ala Gly Glu Gly Gly Lys Pro
         595                 600                 605            
 Cys Pro Pro Ser Gln Ala Leu Gln Glu His Arg Leu Cys Asn Asp His
     610                 615                 620                
 Ser Cys Met Gln Leu His Trp Glu Thr Ser Pro Trp Gly Pro Cys Ser
 625                 630                 635                 640
 Glu Asp Thr Leu Val Thr Ala Leu Asn Ala Thr Ile Gly Trp Asn Gly
                 645                 650                 655    
 Glu Ala Thr Cys Gly Val Gly Ile Gln Thr Arg Arg Val Phe Cys Val
             660                 665                 670        
 Lys Ser His Val Gly Gln Val Met Thr Lys Arg Cys Pro Asp Ser Thr
         675                 680                 685            
 Arg Pro Glu Thr Val Arg Pro Cys Phe Leu Pro Cys Lys Lys Asp Cys
     690                 695                 700                
 Ile Val Thr Ala Phe Ser Glu Trp Thr Pro Cys Pro Arg Met Cys Gln
 705                 710                 715                 720
 Ala Gly Asn Ala Thr Val Lys Gln Ser Arg Tyr Arg Ile Ile Ile Gln
                 725                 730                 735    
 Glu Ala Ala Asn Gly Gly Gln Glu Cys Pro Asp Thr Leu Tyr Glu Glu
             740                 745                 750        
 Arg Glu Cys Glu Asp Val Ser Leu Cys Pro Val Tyr Arg Trp Lys Pro
         755                 760                 765            
 Gln Lys Trp Ser Pro Cys Ile Leu Val Pro Glu Ser Val Trp Gln Gly
     770                 775                 780                
 Ile Thr Gly Ser Ser Glu Ala Cys Gly Lys Gly Leu Gln Thr Arg Ala
 785                 790                 795                 800
 Val Ser Cys Ile Ser Asp Asp Asn Arg Ser Ala Glu Met Met Glu Cys
                 805                 810                 815    
 Leu Lys Gln Thr Asn Gly Met Pro Leu Leu Val Gln Glu Cys Thr Val
             820                 825                 830        
 Pro Cys Arg Glu Asp Cys Thr Phe Thr Ala Trp Ser Lys Phe Thr Pro
         835                 840                 845            
 Cys Ser Thr Asn Cys Glu Ala Thr Lys Ser Arg Arg Arg Gln Leu Thr
     850                 855                 860                
 Gly Lys Ser Arg Lys Lys Glu Lys Cys Gln Asp Ser Asp Leu Tyr Pro
 865                 870                 875                 880
 Leu Val Glu Thr Glu Leu Cys Pro Cys Asp Glu Phe Ile Ser Gln Pro
                 885                 890                 895    
 Tyr Gly Asn Trp Ser Asp Cys Ile Leu Pro Glu Gly Arg Arg Glu Pro
             900                 905                 910        
 His Arg Gly Leu Arg Val Gln Ala Asp Ser Lys Glu Cys Gly Glu Gly
         915                 920                 925            
 Leu Arg Phe Arg Ala Val Ala Cys Ser Asp Lys Asn Gly Arg Pro Val
     930                 935                 940                
 Asp Pro Ser Phe Cys Ser Ser Ser Gly Tyr Ile Gln Glu Lys Cys Val
 945                 950                 955                 960
 Ile Pro Cys Pro Phe Asp Cys Lys Leu Ser Asp Trp Ser Ser Trp Gly
                 965                 970                 975    
 Ser Cys Ser Ser Ser Cys Gly Ile Gly Val Arg Ile Arg Ser Lys Trp
             980                 985                 990        
 Leu Lys Glu Lys Pro Tyr Asn Gly Gly Arg Pro Cys Pro Lys Leu Asp
         995                1000                1005            
 Leu Lys Asn Gln Ala Gln Val His Glu Ala Val Pro Cys Tyr Ser Glu
    1010                1015                1020                
 Cys Asn Gln Tyr Ser Trp Val Val Glu His Trp Ser Ser Cys Lys Ile
1025                1030                1035                1040
 Asn Asn Glu Leu Arg Ser Leu Arg Cys Gly Gly Gly Thr Gln Ser Arg
                1045                1050                1055    
 Lys Ile Arg Cys Val Asn Thr Ala Asp Gly Glu Gly Gly Ala Val Asp
            1060                1065                1070        
 Ser Asn Leu Cys Asn Gln Asp Glu Ile Pro Pro Glu Thr Gln Ser Cys
        1075                1080                1085            
 Ser Leu Met Cys Pro Asn Glu Cys Val Met Ser Glu Trp Gly Leu Trp
    1090                1095                1100                
 Ser Lys Cys Pro Gln Ser Cys Asp Pro His Thr Met Gln Arg Arg Thr
1105                1110                1115                1120
 Arg His Leu Leu Arg Pro Ser Leu Asn Ser Arg Thr Cys Ala Glu Asp
                1125                1130                1135    
 Ser Gln Val Gln Pro Cys Leu Leu Asn Glu Asn Cys Phe Gln Phe Gln
            1140                1145                1150        
 Tyr Asn Leu Thr Glu Trp Ser Thr Cys Gln Leu Ser Glu Asn Ala Pro
        1155                1160                1165            
 Cys Gly Gln Gly Val Arg Thr Arg Leu Leu Ser Cys Val Cys Ser Asp
    1170                1175                1180                
 Gly Lys Pro Val Ser Met Asp Gln Cys Glu Gln His Asn Leu Glu Lys
1185                1190                1195                1200
 Pro Gln Arg Met Ser Ile Pro Cys Leu Val Glu Cys Val Val Asn Cys
                1205                1210                1215    
 Gln Leu Ser Gly Trp Thr Ala Trp Thr Glu Cys Ser Gln Thr Cys Gly
            1220                1225                1230        
 His Gly Gly Arg Met Ser Arg Thr Arg Phe Ile Ile Met Pro Thr Gln
        1235                1240                1245            
 Gly Glu Gly Arg Pro Cys Pro Thr Glu Leu Thr Gln Glu Lys Thr Cys
    1250                1255                1260                
 Pro Val Thr Pro Cys Tyr Ser Trp Val Leu Gly Asn Trp Ser Ala Cys
1265                1270                1275                1280
 Lys Leu Glu Gly Gly Asp Cys Gly Glu Gly Val Gln Ile Arg Ser Leu
                1285                1290                1295    
 Ser Cys Met Val His Ser Gly Ser Ile Ser His Ala Ala Gly Arg Val
            1300                1305                1310        
 Glu Asp Ala Leu Cys Gly Glu Met Pro Phe Gln Asp Ser Ile Leu Lys
        1315                1320                1325            
 Gln Leu Cys Ser Val Pro Cys Pro Gly Asp Cys His Leu Thr Glu Trp
    1330                1335                1340                
 Ser Glu Trp Ser Thr Cys Glu Leu Thr Cys Ile Asp Gly Arg Ser Phe
1345                1350                1355                1360
 Glu Thr Val Gly Arg Gln Ser Arg Ser Arg Thr Phe Ile Ile Gln Ser
                1365                1370                1375    
 Phe Glu Asn Gln Asp Ser Cys Pro Gln Gln Val Leu Glu Thr Arg Pro
            1380                1385                1390        
 Cys Thr Gly Gly Lys Cys Tyr His Tyr Thr Trp Lys Ala Ser Leu Trp
        1395                1400                1405            
 Asn Asn Asn Glu Arg Thr Val Trp Cys Gln Arg Ser Asp Gly Val Asn
    1410                1415                1420                
 Val Thr Gly Gly Cys Ser Pro Gln Ala Arg Pro Ala Ala Ile Arg Gln
1425                1430                1435                1440
 Cys Ile Pro Ala Cys Arg Lys Pro Phe Ser Tyr Cys Thr Gln Gly Gly
                1445                1450                1455    
 Val Cys Gly Cys Glu Lys Gly Tyr Thr Glu Ile Met Arg Ser Asn Gly
            1460                1465                1470        
 Phe Leu Asp Tyr Cys Met Lys Val Pro Gly Ser Glu Asp Lys Lys Ala
        1475                1480                1485            
 Asp Val Lys Asn Leu Ser Gly Lys Asn Arg Pro Val Asn Ser Lys Ile
    1490                1495                1500                
 His Asp Ile Phe Lys Gly Trp Ser Leu Gln Pro Leu Asp Pro Asp Gly
1505                1510                1515                1520
 Arg Val Lys Ile Trp Val Tyr Gly Val Ser Gly Gly Ala Phe Leu Ile
                1525                1530                1535    
 Met Ile Phe Leu Ile Phe Thr Ser Tyr Leu Val Cys Lys Lys Pro Lys
            1540                1545                1550        
 Pro His Gln Ser Thr Pro Pro Gln Gln Lys Pro Leu Thr Leu Ala Tyr
        1555                1560                1565            
 Asp Gly Asp Leu Asp Met
    1570                



      <210> 1120
      <211> 345
      <212> PRT
      <213> Homo sapiens


      <400> 1120
 Met Pro Lys Arg Lys Ala Glu Gly Asp Ala Lys Gly Asp Lys Ala Lys
   1               5                  10                  15    
 Val Lys Asp Glu Pro Gln Arg Arg Ser Ala Arg Leu Ser Ala Lys Pro
              20                  25                  30        
 Ala Pro Pro Lys Pro Glu Pro Lys Pro Lys Lys Ala Pro Ala Lys Lys
          35                  40                  45            
 Ala Lys Gly Lys Lys Gly Lys Ala Asp Ala Gly Lys Glu Gly Asn Asn
      50                  55                  60                
 Pro Ala Glu Asn Gly Asp Ala Lys Thr Asp Gln Ala Gln Lys Ala Glu
  65                  70                  75                  80
 Gly Ala Gly Asp Ala Lys Ser Pro Glu Glu Glu Ser Thr Ser Asn Glu
                  85                  90                  95    
 Gln Gly Gly His His Gln Ser Gln Ser Ser Leu Gly Asn Thr Lys Thr
             100                 105                 110        
 Arg Gln Lys Pro Phe Pro Ser Asn Arg Val Glu Thr Pro Thr Asn Pro
         115                 120                 125            
 Phe His Glu Thr His Ile Ser Ala Arg Pro Ile Leu Thr Glu Ala Thr
     130                 135                 140                
 Arg Ser Gln Thr Cys His Met Tyr Glu Lys Phe Lys Phe Lys Arg Gly
 145                 150                 155                 160
 Glu Glu Gln Phe Tyr Gly Thr Arg Leu Gln Val Met Asp Thr Lys Phe
                 165                 170                 175    
 Arg Glu Asn Glu Glu Leu Glu Arg Cys Ser Ala Met Thr Gln Asn Gly
             180                 185                 190        
 Pro Ser Asn His Thr Lys Ser Asn Thr Gln Gln Leu Glu Thr Pro Ser
         195                 200                 205            
 Pro Gln Phe Ser Val Phe Phe Leu Asp Trp Phe Leu Ile His Ala Ser
     210                 215                 220                
 Gln Ile Cys Lys Ile Ile Arg Arg Ile Lys Tyr Ile Leu Lys Thr Lys
 225                 230                 235                 240
 Ser Lys Lys Val Ile Lys Lys Asp Ser Ala Ala Ser Glu Glu Ile Leu
                 245                 250                 255    
 Asn Val Gln Arg Glu Lys Leu Ser Val Arg Gln Pro Met Ser Arg Pro
             260                 265                 270        
 Trp Tyr Val Ser Ile Phe Phe Leu Gly Asp Glu Glu Ala Ser Pro Val
         275                 280                 285            
 Ser Lys Asn Leu Leu Lys Val Thr Leu Pro Glu Gly Gly Arg Ala Ser
     290                 295                 300                
 Trp Cys Asp Thr Leu Ile Gly Thr Gln Ala Ile Pro Val Leu Ile Ala
 305                 310                 315                 320
 Pro Gln Asn Gln Ala Leu Phe Val Leu Ala Cys Gly Glu Ala Pro Pro
                 325                 330                 335    
 Tyr Phe Pro Lys Gly Asn Pro Ala Asn
             340                 345



      <210> 1121
      <211> 117
      <212> PRT
      <213> Homo sapiens


      <400> 1121
 Met Asn His Thr Val Gln Thr Leu Phe Thr Pro Ala Asn Thr Gly Arg
   1               5                  10                  15    
 Ser Thr Asn His Glu Met Leu Lys Glu Lys His Glu Val Ala Val Leu
              20                  25                  30        
 Gly Ala Pro His Asn Pro Val Pro Pro Ala Phe Thr Met Ile His Ile
          35                  40                  45            
 Cys Ser Glu Thr Ser Val Pro Asp His Val Val Trp Ser Leu Phe Asn
      50                  55                  60                
 Thr Leu Phe Lys Asn Ser Cys Cys Pro Asp Phe Ile Ala Phe Ile Tyr
  65                  70                  75                  80
 Ser Ala Cys Val Ser Thr Ala Lys Cys Leu Asn Ile Trp Ala Leu Ile
                  85                  90                  95    
 Leu Gly Ile Leu Met Thr Ile Leu Leu Ile Ile Ile Pro Val Leu Val
             100                 105                 110        
 Val Gln Ala Gln Arg
         115        



      <210> 1122
      <211> 602
      <212> PRT
      <213> Homo sapiens


      <400> 1122
 Met Gly Ser Asn Ser Ser Arg Ile Gly Asp Leu Pro Lys Asn Glu Tyr
   1               5                  10                  15    
 Leu Lys Lys Leu Ser Gly Thr Glu Ser Ile Ser Glu Asn Asp Pro Phe
              20                  25                  30        
 Trp Asn Gln Leu Leu Ser Phe Ser Phe Pro Ala Pro Thr Ser Ser Ser
          35                  40                  45            
 Glu Leu Lys Leu Leu Glu Glu Ala Thr Ile Ser Val Cys Arg Ser Leu
      50                  55                  60                
 Val Glu Asn Asn Pro Arg Thr Gly Asn Leu Gly Ala Leu Ile Lys Val
  65                  70                  75                  80
 Phe Leu Ser Arg Thr Lys Glu Leu Lys Leu Ser Ala Glu Cys Gln Asn
                  85                  90                  95    
 His Ile Phe Ile Trp Gln Thr His Asn Ala Leu Phe Ile Ile Cys Cys
             100                 105                 110        
 Leu Leu Lys Val Phe Ile Cys Gln Met Ser Glu Glu Glu Leu Gln Leu
         115                 120                 125            
 His Phe Thr Tyr Glu Glu Lys Ser Pro Gly Asn Tyr Ser Ser Asp Ser
     130                 135                 140                
 Glu Asp Leu Leu Glu Glu Leu Leu Cys Cys Leu Met Gln Leu Ile Thr
 145                 150                 155                 160
 Asp Ile Pro Leu Leu Asp Ile Thr Tyr Glu Ile Ser Val Glu Ala Ile
                 165                 170                 175    
 Ser Thr Met Val Val Phe Leu Ser Cys Gln Leu Phe His Lys Glu Val
             180                 185                 190        
 Leu Arg Gln Ser Ile Ser His Lys Tyr Leu Met Arg Gly Pro Cys Leu
         195                 200                 205            
 Pro Tyr Thr Ser Lys Leu Val Lys Thr Leu Leu Tyr Asn Phe Ile Arg
     210                 215                 220                
 Gln Glu Lys Pro Pro Pro Pro Gly Ala His Val Phe Pro Gln Gln Ser
 225                 230                 235                 240
 Asp Gly Gly Gly Leu Leu Tyr Gly Leu Ala Ser Gly Val Ala Thr Gly
                 245                 250                 255    
 Leu Trp Thr Val Phe Thr Leu Gly Gly Val Gly Ser Lys Ala Ala Ala
             260                 265                 270        
 Ser Pro Glu Leu Ser Ser Pro Leu Ala Asn Gln Ser Leu Leu Leu Leu
         275                 280                 285            
 Leu Val Leu Ala Asn Leu Thr Asp Ala Ser Asp Ala Pro Asn Pro Tyr
     290                 295                 300                
 Arg Gln Ala Ile Met Ser Phe Lys Asn Thr Gln Asp Ser Ser Pro Phe
 305                 310                 315                 320
 Pro Ser Ser Ile Pro His Ala Phe Gln Ile Asn Phe Asn Ser Leu Tyr
                 325                 330                 335    
 Thr Ala Leu Cys Glu Gln Gln Thr Ser Asp Gln Ala Thr Leu Leu Leu
             340                 345                 350        
 Tyr Thr Leu Leu His Gln Asn Ser Asn Ile Arg Thr Tyr Met Leu Ala
         355                 360                 365            
 Arg Thr Asp Met Glu Asn Leu Val Leu Pro Ile Leu Glu Ile Leu Tyr
     370                 375                 380                
 His Val Glu Glu Arg Asn Ser His His Val Tyr Met Ala Leu Ile Ile
 385                 390                 395                 400
 Leu Leu Ile Leu Thr Glu Asp Asp Gly Phe Asn Arg Ser Ile His Glu
                 405                 410                 415    
 Val Ile Leu Lys Asn Ile Thr Trp Tyr Ser Glu Arg Val Leu Thr Glu
             420                 425                 430        
 Ile Ser Leu Gly Ser Leu Leu Ile Leu Val Val Ile Arg Thr Ile Gln
         435                 440                 445            
 Tyr Asn Met Thr Arg Thr Arg Asp Lys Tyr Leu His Thr Asn Cys Leu
     450                 455                 460                
 Ala Ala Leu Ala Asn Met Ser Ala Gln Phe Arg Ser Leu His Gln Tyr
 465                 470                 475                 480
 Ala Ala Gln Arg Ile Ile Ser Leu Phe Ser Leu Leu Ser Lys Lys His
                 485                 490                 495    
 Asn Lys Val Leu Glu Gln Ala Thr Gln Ser Leu Arg Gly Ser Leu Ser
             500                 505                 510        
 Ser Asn Asp Val Pro Leu Pro Asp Tyr Ala Gln Asp Leu Asn Val Ile
         515                 520                 525            
 Glu Glu Val Ile Arg Met Met Leu Glu Ile Ile Asn Ser Cys Leu Thr
     530                 535                 540                
 Asn Ser Leu His His Asn Pro Asn Leu Val Tyr Ala Leu Leu Tyr Lys
 545                 550                 555                 560
 Arg Asp Leu Phe Glu Gln Phe Arg Thr His Pro Ser Phe Gln Asp Ile
                 565                 570                 575    
 Met Gln Asn Ile Asp Leu Val Ser Val Asn Glu Asp Ile Tyr Tyr Asp
             580                 585                 590        
 Ser Phe Leu Ser Ile Lys Ala Glu Asn Val
         595                 600        



      <210> 1123
      <211> 229
      <212> PRT
      <213> Homo sapiens


      <400> 1123
 Met Val Pro Arg Val Pro Gly Ser Gly Trp Ala His Arg Phe Ala Leu
   1               5                  10                  15    
 Ser Pro Arg Leu Val Gly Gly Gly Ile Arg Ala Ser Phe Arg Arg Ser
              20                  25                  30        
 Leu Ala Pro Gln Val Pro Thr Phe Tyr Leu Pro Tyr Phe Leu Glu Ala
          35                  40                  45            
 Gly Leu Glu Ala Ala Ala Leu Val Phe Leu Leu Leu Thr Ala Asp Cys
      50                  55                  60                
 Cys Gly Arg Arg Pro Val Leu Leu Leu Gly Thr Met Val Thr Gly Leu
  65                  70                  75                  80
 Ala Ser Leu Leu Leu Leu Ala Gly Ala Gln Tyr Leu Pro Gly Trp Thr
                  85                  90                  95    
 Val Leu Phe Leu Ser Val Leu Gly Leu Leu Ala Ser Arg Ala Val Ser
             100                 105                 110        
 Ala Leu Ser Ser Leu Phe Ala Ala Glu Val Phe Pro Thr Val Ile Arg
         115                 120                 125            
 Gly Ala Gly Leu Gly Leu Val Leu Gly Ala Gly Phe Leu Gly Gln Ala
     130                 135                 140                
 Ala Gly Pro Leu Asp Thr Leu His Gly Arg Gln Gly Phe Phe Leu Gln
 145                 150                 155                 160
 Gln Val Val Phe Ala Ser Leu Ala Val Leu Ala Leu Leu Cys Val Leu
                 165                 170                 175    
 Leu Leu Pro Glu Ser Arg Ser Arg Gly Leu Pro Gln Ser Leu Gln Asp
             180                 185                 190        
 Ala Asp Arg Leu Arg Arg Ser Pro Leu Leu Arg Gly Arg Pro Arg Gln
         195                 200                 205            
 Asp His Leu Pro Leu Leu Pro Pro Ser Asn Ser Tyr Trp Ala Gly His
     210                 215                 220                
 Thr Pro Glu Gln His
 225                



      <210> 1124
      <211> 480
      <212> PRT
      <213> Homo sapiens


      <400> 1124
 Met Asn Lys Gln Arg Gly Thr Tyr Ser Glu Val Ser Leu Ala Gln Asp
   1               5                  10                  15    
 Pro Lys Arg Gln Gln Arg Lys Leu Lys Gly Asn Lys Ile Ser Ile Ser
              20                  25                  30        
 Gly Thr Lys Gln Glu Ile Phe Gln Val Glu Leu Asn Leu Gln Asn Ala
          35                  40                  45            
 Ser Ser Asp His Gln Gly Asn Asp Lys Thr Tyr His Cys Lys Gly Leu
      50                  55                  60                
 Leu Pro Pro Pro Glu Lys Leu Thr Ala Glu Val Leu Gly Ile Ile Cys
  65                  70                  75                  80
 Ile Val Leu Met Ala Thr Val Leu Lys Thr Ile Val Leu Ile Pro Cys
                  85                  90                  95    
 Ile Gly Val Leu Glu Gln Asn Asn Phe Ser Leu Asn Arg Arg Met Gln
             100                 105                 110        
 Lys Glu Met Ser Glu Phe His Asn Tyr Asn Leu Asp Leu Lys Lys Ser
         115                 120                 125            
 Asp Phe Ser Thr Arg Trp Gln Lys Gln Arg Cys Pro Val Val Lys Ser
     130                 135                 140                
 Lys Cys Arg Glu Asn Ala Ser Pro Phe Phe Phe Cys Cys Phe Ile Ala
 145                 150                 155                 160
 Val Ala Met Gly Ile Arg Phe Ile Ile Met Val Ala Ile Trp Ser Ala
                 165                 170                 175    
 Val Phe Leu Asn Ser Leu Phe Asn Gln Glu Val Gln Ile Pro Leu Thr
             180                 185                 190        
 Glu Ser Tyr Cys Gly Pro Cys Pro Lys Asn Trp Ile Cys Tyr Lys Asn
         195                 200                 205            
 Asn Cys Tyr Gln Phe Phe Asp Glu Ser Lys Asn Trp Tyr Glu Ser Gln
     210                 215                 220                
 Ala Ser Cys Met Ser Gln Asn Ala Ser Leu Leu Lys Val Tyr Ser Lys
 225                 230                 235                 240
 Glu Asp Gln Val Gln Gln Thr Arg Ser Tyr Tyr Arg Ser Phe Gly His
                 245                 250                 255    
 Cys Leu Ala Arg Lys Val Ser Ser Pro Val Thr Ala Cys Tyr Ser Cys
             260                 265                 270        
 Lys Ala Arg Pro Ile Ser Cys Met Gln Cys Pro Arg Ser Asp Phe Pro
         275                 280                 285            
 Pro His Ser Pro Gln Ser Thr Gln Pro Val Leu Arg Asp Leu Cys Leu
     290                 295                 300                
 Pro Thr Ser Leu Pro Ala Leu Ala Ser Pro Glu Thr Ile Ala Phe Thr
 305                 310                 315                 320
 His Phe His Thr Pro Ser Leu Pro Gln Asp Ser Ser Leu Asp Glu Met
                 325                 330                 335    
 Ser Leu Ser His Val Pro Asp Pro Val Asn His Phe His Phe Val Ser
             340                 345                 350        
 Gly Asp Ile Ser Phe Ile Gln Ile Gly Arg Pro Leu Leu Leu Pro Pro
         355                 360                 365            
 Ala Thr Leu Gly Trp Ile Ser Gly Gln Ser Leu Gly Gly Asp Gln Ala
     370                 375                 380                
 Pro Leu Cys Pro Tyr Gly Thr Gly Phe Pro Ala Leu Gly Leu Tyr Ser
 385                 390                 395                 400
 Leu Pro Gln Phe Leu Lys Cys Trp Tyr Arg Pro Ala Ala Pro Ser Ser
                 405                 410                 415    
 Val Pro Leu Arg Cys Gln Ala Gly Cys Trp Asp Val Gly Arg Ala Gly
             420                 425                 430        
 Leu Tyr Ile Arg Val Lys Leu Ser Cys Gly Thr Pro Trp Met Pro Gly
         435                 440                 445            
 Leu Ser Trp Pro Arg Gly Pro Ser Ile Ala Gly Lys Gly Asp Ser Lys
     450                 455                 460                
 Ser Val Ile Ser Asn Pro Asp Glu Pro Pro Glu Met Tyr Arg Asp Ile
 465                 470                 475                 480





      <210> 1125
      <211> 442
      <212> PRT
      <213> Homo sapiens


      <400> 1125
 Met Gln Thr Asp Pro Arg Val Gly Phe Cys Arg Val Gln Asp Glu Ser
   1               5                  10                  15    
 Lys Ser Pro Arg Leu Ala Phe Glu Ala His His Lys Arg Leu Ser Gln
              20                  25                  30        
 Pro Pro Ala Asn Asp Gly His Leu Ile Gln Thr Ala Arg Ser Gly Tyr
          35                  40                  45            
 Thr Asp Ser Gly Tyr Arg Ile Arg Asp Leu Asp Glu Asp Phe Gly Thr
      50                  55                  60                
 Ala Thr Leu Gly Trp Ala Gly Gln Glu Val Gln Thr Glu Asn Val Thr
  65                  70                  75                  80
 Val Ala Glu Gly Gly Val Ala Glu Ile Thr Cys Arg Leu His Gln Tyr
                  85                  90                  95    
 Asp Gly Ser Ile Val Val Ile Gln Asn Pro Ala Arg Gln Thr Leu Phe
             100                 105                 110        
 Phe Asn Gly Thr Arg Ala Leu Lys Asp Glu Arg Phe Gln Leu Glu Glu
         115                 120                 125            
 Phe Ser Pro Arg Arg Val Arg Ile Arg Leu Ser Asp Ala Arg Leu Glu
     130                 135                 140                
 Asp Glu Gly Gly Tyr Phe Cys Gln Leu Tyr Thr Glu Asp Thr His His
 145                 150                 155                 160
 Gln Ile Ala Thr Leu Thr Val Leu Val Ala Pro Glu Asn Pro Val Val
                 165                 170                 175    
 Glu Val Arg Glu Gln Ala Val Glu Gly Gly Glu Val Glu Leu Ser Cys
             180                 185                 190        
 Leu Val Pro Arg Ser Arg Pro Ala Ala Thr Leu Arg Trp Tyr Arg Asp
         195                 200                 205            
 Arg Lys Glu Leu Lys Val Ser Asp Arg Gly Val Ala Gly Val Ser Ser
     210                 215                 220                
 Ser Gln Glu Asn Gly Lys Val Trp Ser Val Ala Ser Thr Val Arg Phe
 225                 230                 235                 240
 Arg Val Asp Arg Lys Asp Asp Gly Gly Ile Ile Ile Cys Glu Ala Gln
                 245                 250                 255    
 Asn Gln Ala Leu Pro Ser Gly His Ser Lys Gln Thr Gln Tyr Val Leu
             260                 265                 270        
 Asp Val Gln Tyr Ser Pro Thr Ala Arg Ile His Ala Ser Gln Ala Val
         275                 280                 285            
 Val Arg Glu Gly Asp Thr Leu Val Leu Thr Cys Ala Val Thr Gly Asn
     290                 295                 300                
 Pro Arg Pro Asn Gln Ile Arg Trp Asn Arg Gly Asn Glu Ser Leu Pro
 305                 310                 315                 320
 Glu Arg Ala Glu Ala Val Gly Glu Thr Leu Thr Leu Pro Gly Leu Val
                 325                 330                 335    
 Ser Ala Asp Asn Gly Thr Tyr Thr Cys Glu Ala Ser Asn Lys His Gly
             340                 345                 350        
 His Ala Arg Ala Leu Tyr Val Leu Val Val Tyr Asp Pro Gly Ala Val
         355                 360                 365            
 Val Glu Ala Gln Thr Ser Val Pro Tyr Ala Ile Val Gly Gly Ile Leu
     370                 375                 380                
 Ala Leu Leu Val Phe Leu Ile Ile Cys Val Leu Val Gly Met Val Trp
 385                 390                 395                 400
 Cys Ser Val Arg Gln Lys Gly Ser Tyr Leu Thr His Glu Ala Ser Gly
                 405                 410                 415    
 Leu Asp Glu Gln Gly Glu Val Arg Glu Ala Phe Leu Asn Gly Ser Asp
             420                 425                 430        
 Gly His Lys Arg Lys Glu Glu Phe Phe Ile
         435                 440        



      <210> 1126
      <211> 1651
      <212> PRT
      <213> Homo sapiens


      <400> 1126
 Met Asp Ala Val Met Ser Asp Gly Asn Leu Glu Thr Arg Leu Gly Ser
   1               5                  10                  15    
 Thr Asp Val Ala Ala Ser Gln His Met Leu Val Cys Ala Leu Gln Glu
              20                  25                  30        
 Leu Gly Asn Leu Ile His Asn Leu Gly Thr Thr Ala Ala Pro Leu Leu
          35                  40                  45            
 Gln Asp Ser Ser Thr Gly Leu Leu Asp Ser Ile Leu Ser Val Ile Leu
      50                  55                  60                
 His Pro Ser Ile Ser Val Arg Leu Ala Ala Ala Trp Cys Leu His Cys
  65                  70                  75                  80
 Ile Ala Val Ala Leu Pro Ser Tyr Leu Thr Pro Leu Leu Asp Arg Cys
                  85                  90                  95    
 Leu Glu Arg Leu Thr Gly His Lys Ser Ser Pro Glu Ala Val Thr Gly
             100                 105                 110        
 Phe Ser Phe Ala Val Ala Ala Leu Leu Gly Ala Val Lys His Cys Pro
         115                 120                 125            
 Leu Gly Ile Pro His Gly Lys Gly Lys Ile Ile Met Thr Leu Ala Glu
     130                 135                 140                
 Asp Leu Leu Cys Ser Ala Ala Gln Asn Ser Arg Leu Ser Ala Gln Arg
 145                 150                 155                 160
 Thr Gln Ala Gly Trp Leu Leu Ile Ser Ala Leu Met Thr Leu Gly Pro
                 165                 170                 175    
 Ala Val Val Ser His His Leu Ala Arg Val Leu Leu Leu Trp Lys Cys
             180                 185                 190        
 Val Phe Pro Ala Ser Pro Lys Asp Leu Glu Thr Glu Lys Ser Arg Gly
         195                 200                 205            
 Asp Ser Phe Thr Trp Gln Val Thr Leu Glu Gly Arg Ala Gly Ala Leu
     210                 215                 220                
 Cys Ala Ile Lys Ser Phe Val Ser His Cys Gly Asp Leu Leu Thr Glu
 225                 230                 235                 240
 Glu Val Thr Gln Arg Leu Leu Pro Pro Leu Pro Cys Ala Val Asp Leu
                 245                 250                 255    
 Leu Thr Gln Leu Ser Ser Ile Leu Lys Met Tyr Gly Ser Pro Leu Lys
             260                 265                 270        
 Thr Pro Ser Val Val Tyr Arg Gln Arg Leu Tyr Glu Leu Leu Ile Leu
         275                 280                 285            
 Leu Pro Pro Glu Thr Tyr Glu Gly Asn Leu Cys Ala Ile Leu Arg Glu
     290                 295                 300                
 Leu Ala Ala Asp Leu Thr Ala Pro Asp Ile Gln Val Ala Ala Ser Thr
 305                 310                 315                 320
 Phe Leu Leu Pro Pro Leu Cys His Gln Asp Asp Leu Leu Ile Leu Ser
                 325                 330                 335    
 Pro Phe Leu Gln Glu Thr Asp His Arg Phe Ile Glu Glu Gln Leu Leu
             340                 345                 350        
 Leu Gly Asn Gly Val Ala Cys Gly Ser Leu Glu Tyr Asp Pro Tyr Ser
         355                 360                 365            
 Ile Tyr Glu Lys Asp Val Glu Gly Asp Ser Val Pro Lys Pro Leu Pro
     370                 375                 380                
 Pro Ala Leu Ser Val Ile Ser Ser Ala Ser Lys Leu Phe Gly Val Val
 385                 390                 395                 400
 Cys Ala His Val Gly Glu Thr Gln Arg Leu Leu Ile Leu Glu Gln Leu
                 405                 410                 415    
 Leu Asp Ser Ile Lys His Thr Lys Gly Ala Arg Gln Gln Val Val Gln
             420                 425                 430        
 Leu His Val Val Ser Ser Val Ser Ser Phe Leu Lys Tyr Val Ala Gly
         435                 440                 445            
 Ser Lys Gly Cys Leu Gly Pro Glu Glu Met Lys Arg Phe Ala Leu Thr
     450                 455                 460                
 Leu Val Met Gly Ala Leu Glu Ser Pro Asn Pro Leu Leu Arg Cys Ala
 465                 470                 475                 480
 Ala Ala Glu Ser Trp Ala Arg Leu Ala Gln Met Val Asp Asp Gly Ala
                 485                 490                 495    
 Phe Thr Ala Gly Leu Ala Gln Val Ser Phe Asp Lys Leu Lys Ser Ala
             500                 505                 510        
 Arg Asp Val Val Thr Arg Thr Gly His Ser Leu Ala Leu Gly Ser Leu
         515                 520                 525            
 His Arg Tyr Leu Gly Gly Ile Ser Ser Ser Gln His Leu Asn Ser Cys
     530                 535                 540                
 Ile Gly Ile Leu Tyr Thr Leu Ala Gln Asp Ser Thr Ser Pro Asp Val
 545                 550                 555                 560
 Gln Thr Trp Ala Leu His Ser Leu Ser Leu Ile Ile Asp Ser Ala Gly
                 565                 570                 575    
 Pro Leu Tyr Tyr Val His Val Glu Pro Thr Leu Ser Leu Ile Ile Met
             580                 585                 590        
 Leu Leu Leu Asn Val Pro Pro Thr His Ala Glu Val His Gln Ser Leu
         595                 600                 605            
 Gly Arg Cys Leu Asn Ala Leu Ile Thr Thr Leu Gly Pro Glu Leu Gln
     610                 615                 620                
 Gly Asn Ser Thr Ser Ile Ser Thr Leu Arg Thr Ser Cys Leu Leu Gly
 625                 630                 635                 640
 Cys Ala Val Met Gln Asp Asn Pro Asp Cys Leu Val Gln Ala Gln Ala
                 645                 650                 655    
 Ile Ser Cys Leu Gln Gln Leu His Met Phe Ala Pro Arg His Val Asn
             660                 665                 670        
 Leu Ser Ser Leu Val Ser Cys Leu Cys Val Asn Leu Cys Ser Pro Tyr
         675                 680                 685            
 Leu Leu Leu Arg Arg Ala Val Leu Ala Cys Leu Arg Gln Leu Val Gln
     690                 695                 700                
 Arg Glu Ala Ala Glu Val Ser Glu His Ala Val Met Leu Ala Lys Asp
 705                 710                 715                 720
 Ser Arg Glu Glu Leu Thr Pro Asp Ala Asn Ile Arg Glu Val Gly Leu
                 725                 730                 735    
 Glu Gly Ala Leu Leu Ile Leu Leu Asp Lys Glu Thr Asp Glu Arg Leu
             740                 745                 750        
 Cys His Asp Ile Lys Glu Thr Leu Asn Tyr Met Leu Thr Ser Met Ala
         755                 760                 765            
 Val Glu Lys Leu Ser Leu Trp Leu Lys Leu Cys Lys Asp Val Leu Ala
     770                 775                 780                
 Ala Ser Ala Asp Phe Thr Ala Val Thr Cys Val Asp Thr Met Gln Glu
 785                 790                 795                 800
 Glu Glu Gly Asp Lys Gly Asp Asp Ala Ser Val Leu Thr Thr Arg Arg
                 805                 810                 815    
 Asp Glu Lys Ser His Pro Phe Thr Asn Pro Arg Trp Ala Thr Arg Val
             820                 825                 830        
 Phe Ala Ala Glu Cys Val Cys Arg Ile Ile Asn Gln Cys Glu Asn Ala
         835                 840                 845            
 Asn Ser Ala His Phe Asp Ile Ala Leu Ala Gln Glu Met Lys Lys Arg
     850                 855                 860                
 Asp Ser Arg Asn Asp Phe Leu Val Leu His Leu Ala Asp Leu Ile Arg
 865                 870                 875                 880
 Met Ala Phe Met Ala Ala Thr Asp His Ser Asp Gln Leu Arg Leu Ser
                 885                 890                 895    
 Gly Leu Glu Met Leu Leu Val Val Ile Arg Arg Phe Ala Thr Val Pro
             900                 905                 910        
 Glu Pro Glu Phe Pro Gly His Val Ile Leu Glu Gln Tyr Gln Ala Asn
         915                 920                 925            
 Val Gly Ala Ala Leu Arg Pro Ala Phe Thr Ser Glu Thr Pro Pro Asp
     930                 935                 940                
 Val Thr Ala Lys Ala Cys Gln Val Cys Ser Ala Trp Ile Ala Ser Gly
 945                 950                 955                 960
 Val Val Ser Asp Leu Asn Asp Leu Arg Arg Val His Gln Leu Leu Val
                 965                 970                 975    
 Ser Ser Leu Thr Lys Ile Gln Ala Gly Lys Glu Ala Leu Ser His Leu
             980                 985                 990        
 Tyr Asn Glu Ser Ala Ser Thr Met Glu Ile Leu Ala Val Leu Lys Ala
         995                1000                1005            
 Trp Ala Glu Val Tyr Ile Ile Ala Val Gln Arg His Lys Asn His Arg
    1010                1015                1020                
 Gln Pro Leu Lys Thr Thr Thr Cys Leu Glu Asp Gly Ile Arg Asn Gly
1025                1030                1035                1040
 Ser Cys Ser Ser Asp Gly Leu Leu Asp Leu Val Tyr Ala Asp Leu Gly
                1045                1050                1055    
 Thr Leu Ser Arg Leu Trp Leu Ala Ala Leu Gln Asp Phe Ala Leu Leu
            1060                1065                1070        
 Thr Leu Pro Ser Glu Phe Ala Ser Gln Leu Pro Ala Glu Gly Gly Ala
        1075                1080                1085            
 Phe Tyr Thr Ala Glu Thr Ser Glu Asn Ala Lys Leu His Tyr Tyr Asn
    1090                1095                1100                
 Ser Trp Ala Leu Ile Leu His Ala Thr Ala Leu Trp Leu Thr Ser Thr
1105                1110                1115                1120
 Gly Phe Val Val Ala Asp Pro Asp Glu Gly Ala Ser Asn Leu Ser Arg
                1125                1130                1135    
 Pro Val Thr Pro Thr Ser Met Cys Gln Gly Ser Ser Ser Gly Ala Thr
            1140                1145                1150        
 Ile Lys Ser Pro Glu Asp Val Tyr Thr Asp Arg Phe His Leu Ile Leu
        1155                1160                1165            
 Gly Ile Ser Val Glu Phe Leu Cys Ser Leu Arg Ser Asp Ala Thr Met
    1170                1175                1180                
 Glu Ser Ile Thr Ala Cys Leu His Ala Leu Gln Ala Leu Leu Asp Val
1185                1190                1195                1200
 Pro Trp Pro Arg Ser Lys Ile Gly Ser Asp Gln Asp Leu Gly Ile Glu
                1205                1210                1215    
 Leu Leu Asn Val Leu His Arg Val Ile Leu Thr Arg Glu Ser Pro Ser
            1220                1225                1230        
 Ile Gln Leu Ala Ser Leu Glu Val Val Arg Gln Ile Ile Cys Ala Ala
        1235                1240                1245            
 Gln Glu His Val Lys Glu Lys Arg Arg Ser Ala Glu Val Asp Asp Gly
    1250                1255                1260                
 Ala Ala Glu Lys Glu Thr Leu Pro Glu Phe Gly Glu Gly Lys Asp Thr
1265                1270                1275                1280
 Gly Gly Leu Val Pro Gly Lys Ser Leu Val Phe Ala Thr Leu Glu Leu
                1285                1290                1295    
 Cys Val Cys Ile Leu Val Arg Gln Leu Pro Glu Leu Asn Pro Lys Leu
            1300                1305                1310        
 Thr Gly Ser Pro Gly Val Lys Ala Thr Lys Pro Gln Ile Leu Leu Glu
        1315                1320                1325            
 Asp Gly Ser Arg Leu Val Ser Ala Ala Leu Val Ile Leu Ser Glu Leu
    1330                1335                1340                
 Pro Ala Val Cys Ser Pro Glu Gly Ser Ile Ser Ile Leu Pro Thr Ile
1345                1350                1355                1360
 Leu Tyr Leu Thr Ile Gly Val Leu Arg Glu Thr Ala Val Lys Leu Pro
                1365                1370                1375    
 Gly Gly Gln Leu Ser Ser Thr Val Ala Ala Ser Leu Gln Ala Leu Lys
            1380                1385                1390        
 Gly Ile Leu Ser Ser Pro Met Ala Arg Ala Glu Lys Ser Arg Thr Ala
        1395                1400                1405            
 Trp Thr Asp Leu Leu Arg Ser Ala Leu Thr Thr Ile Leu Asp Cys Trp
    1410                1415                1420                
 Asp Pro Val Asp Glu Thr His Gln Glu Leu Asp Glu Val Ser Leu Leu
1425                1430                1435                1440
 Thr Ala Ile Thr Val Phe Ile Leu Ser Thr Ser Pro Glu Val Thr Thr
                1445                1450                1455    
 Ile Pro Cys Leu Gln Lys Arg Cys Ile Asp Lys Phe Lys Ala Thr Leu
            1460                1465                1470        
 Glu Ile Lys Asp Pro Val Val Gln Ile Lys Thr Tyr Gln Leu Leu His
        1475                1480                1485            
 Ser Ile Phe Gln Tyr Pro Asn Pro Ala Val Ser Tyr Pro Tyr Ile Tyr
    1490                1495                1500                
 Ser Leu Ala Ser Cys Ile Met Glu Lys Leu Gln Glu Ile Asp Lys Arg
1505                1510                1515                1520
 Lys Pro Glu Asn Thr Ala Glu Leu Glu Ile Phe Gln Glu Gly Ile Lys
                1525                1530                1535    
 Val Leu Glu Thr Leu Val Thr Val Ala Glu Glu His His Arg Ala Gln
            1540                1545                1550        
 Leu Val Ala Cys Leu Leu Pro Ile Leu Ile Ser Phe Leu Leu Asp Glu
        1555                1560                1565            
 Asn Ser Leu Gly Ser Ala Thr Ser Ile Met Arg Asn Leu His Asp Phe
    1570                1575                1580                
 Ala Leu Gln Asn Leu Met Gln Ile Gly Pro Gln Tyr Ser Ser Val Phe
1585                1590                1595                1600
 Lys Ser Leu Val Ala Ser Ser Pro Ala Leu Lys Ala Arg Leu Glu Ala
                1605                1610                1615    
 Ala Ile Lys Gly Asn Gln Glu Ser Val Lys Val Lys Ile Pro Thr Ser
            1620                1625                1630        
 Lys Tyr Thr Lys Ser Pro Gly Lys Asn Ser Ser Ile Gln Leu Lys Thr
        1635                1640                1645            
 Ser Phe Leu
    1650    



      <210> 1127
      <211> 211
      <212> PRT
      <213> Homo sapiens


      <400> 1127
 Met Ser Glu Arg Trp Lys Arg Arg Gly Asn Ser Thr Arg Thr Ser Ser
   1               5                  10                  15    
 Leu Ala Ser Gly Ala Gly Asp Pro Glu Pro Asp Leu Trp Ile Ile Gln
              20                  25                  30        
 Pro Gln Glu Leu Val Leu Gly Thr Thr Gly Asp Thr Val Phe Leu Asn
          35                  40                  45            
 Cys Thr Val Leu Gly Asp Gly Pro Pro Gly Pro Ile Arg Trp Phe Gln
      50                  55                  60                
 Gly Ala Gly Leu Ser Arg Glu Ala Ile Tyr Asn Phe Gly Gly Ile Ser
  65                  70                  75                  80
 His Pro Lys Glu Thr Ala Val Gln Ala Ser Asn Asn Asp Phe Ser Ile
                  85                  90                  95    
 Leu Leu Gln Asn Val Ser Ser Glu Asp Ala Gly Thr Tyr Tyr Cys Val
             100                 105                 110        
 Lys Phe Gln Arg Lys Pro Asn Arg Gln Tyr Leu Ser Gly Gln Gly Thr
         115                 120                 125            
 Ser Leu Lys Val Lys Ala Lys Ser Thr Ser Ser Lys Glu Ala Glu Phe
     130                 135                 140                
 Thr Ser Glu Pro Ala Thr Glu Met Ser Pro Thr Gly Leu Leu Val Val
 145                 150                 155                 160
 Phe Ala Pro Val Val Leu Gly Leu Lys Ala Ile Thr Leu Ala Ala Leu
                 165                 170                 175    
 Leu Leu Ala Leu Ala Thr Ser Arg Arg Ser Pro Gly Gln Glu Asp Val
             180                 185                 190        
 Lys Thr Thr Gly Pro Ala Gly Ala Met Asn Thr Leu Ala Trp Ser Lys
         195                 200                 205            
 Gly Gln Glu
     210    



      <210> 1128
      <211> 398
      <212> PRT
      <213> Homo sapiens


      <400> 1128
 Met Asp Gly Val Thr Pro Thr Leu Ser Thr Ile Arg Gly Arg Thr Leu
   1               5                  10                  15    
 Glu Ser Ser Thr Leu His Val Thr Pro Arg Ser Leu Asp Arg Asn Lys
              20                  25                  30        
 Asp Gln Ile Thr Asn Ile Phe Ser Gly Phe Ala Gly Leu Leu Ala Ile
          35                  40                  45            
 Leu Leu Val Val Ala Val Phe Cys Ile Leu Trp Asn Trp Asn Lys Arg
      50                  55                  60                
 Lys Lys Arg Gln Val Pro Tyr Leu Arg Val Thr Val Met Pro Leu Leu
  65                  70                  75                  80
 Thr Leu Pro Gln Thr Arg Gln Arg Ala Lys Asn Ile Tyr Asp Ile Leu
                  85                  90                  95    
 Pro Trp Arg Gln Glu Asp Leu Gly Arg His Glu Ser Arg Ser Met Arg
             100                 105                 110        
 Ile Phe Ser Thr Glu Ser Leu Leu Ser Arg Asn Ser Glu Ser Pro Glu
         115                 120                 125            
 His Val Pro Ser Gln Ala Gly Asn Ala Phe Gln Glu His Thr Ala His
     130                 135                 140                
 Ile His Ala Thr Glu Tyr Ala Val Gly Ile Tyr Asp Asn Ala Met Val
 145                 150                 155                 160
 Pro Gln Met Cys Gly Asn Leu Thr Pro Ser Ala His Cys Ile Asn Val
                 165                 170                 175    
 Arg Ala Ser Arg Asp Cys Ala Ser Ile Ser Ser Glu Asp Ser His Asp
             180                 185                 190        
 Tyr Val Asn Val Pro Thr Ala Glu Glu Ile Ala Glu Thr Leu Ala Ser
         195                 200                 205            
 Thr Lys Ser Pro Ser Arg Asn Leu Phe Val Leu Pro Ser Thr Gln Lys
     210                 215                 220                
 Leu Glu Phe Thr Glu Glu Arg Asp Glu Gly Cys Gly Asp Ala Gly Asp
 225                 230                 235                 240
 Cys Thr Ser Leu Tyr Ser Pro Gly Ala Glu Asp Ser Asp Ser Leu Ser
                 245                 250                 255    
 Asn Gly Glu Gly Ser Ser Gln Ile Ser Asn Asp Tyr Val Asn Met Thr
             260                 265                 270        
 Gly Leu Asp Leu Ser Ala Ile Gln Glu Arg Gln Leu Trp Val Ala Phe
         275                 280                 285            
 Gln Cys Cys Arg Asp Tyr Glu Asn Val Pro Ala Ala Asp Pro Ser Gly
     290                 295                 300                
 Ser Gln Gln Gln Ala Glu Lys Asp Val Pro Ser Ser Asn Ile Gly His
 305                 310                 315                 320
 Val Glu Asp Lys Thr Asp Asp Pro Gly Thr His Val Gln Cys Val Lys
                 325                 330                 335    
 Arg Thr Phe Leu Ala Ser Gly Asp Tyr Ala Asp Phe Gln Pro Phe Thr
             340                 345                 350        
 Gln Ser Glu Asp Ser Gln Met Lys His Arg Glu Glu Met Ser Asn Glu
         355                 360                 365            
 Asp Ser Ser Asp Tyr Glu Asn Val Leu Thr Ala Lys Leu Gly Gly Arg
     370                 375                 380                
 Asp Ser Glu Gln Gly Pro Gly Thr Gln Leu Leu Pro Asp Glu
 385                 390                 395            



      <210> 1129
      <211> 523
      <212> PRT
      <213> Homo sapiens


      <400> 1129
 Met Gly Gly Cys Val Glu Arg Asn Ala Met Ala His Arg Asp Ser Glu
   1               5                  10                  15    
 Met Lys Glu Glu Cys Leu Arg Glu Asp Leu Lys Phe Tyr Phe Met Ser
              20                  25                  30        
 Pro Cys Glu Lys Tyr Arg Ala Arg Arg Gln Ile Pro Trp Lys Leu Gly
          35                  40                  45            
 Leu Gln Ile Leu Lys Ile Val Met Val Thr Thr Gln Tyr His Gln Leu
      50                  55                  60                
 Lys Asp Ile Thr Leu Gly Thr Leu Gly Tyr Gly Glu Asn Glu Asp Asn
  65                  70                  75                  80
 Arg Ile Gly Leu Lys Val Cys Lys Gln His Tyr Lys Lys Gly Thr Met
                  85                  90                  95    
 Phe Pro Ser Asn Glu Thr Leu Asn Ile Asp Asn Asp Val Glu Leu Asp
             100                 105                 110        
 Cys Val Gln Leu Asp Leu Gln Asp Leu Ser Lys Lys Pro Pro Asp Trp
         115                 120                 125            
 Lys Asn Ser Ser Phe Phe Arg Leu Glu Phe Tyr Arg Tyr Ala Glu Ile
     130                 135                 140                
 Arg Gly Ile Phe Ser Lys Ser Lys Tyr Arg Leu Pro Ile Phe Cys Glu
 145                 150                 155                 160
 Lys Lys Leu Thr Phe Val Lys Tyr Val Ile Trp Asn Ile Ile Ile Lys
                 165                 170                 175    
 Ile Lys Met Met Glu Ile Ser Lys Leu Val Ser Gln Met His Phe Gln
             180                 185                 190        
 Asn Thr Gln Lys Asn Ala Gln Tyr Val Leu Val Phe Asp Ala Phe Val
         195                 200                 205            
 Ile Val Ile Cys Leu Ala Ser Leu Ile Leu Cys Thr Arg Ser Ile Val
     210                 215                 220                
 Leu Ala Leu Arg Leu Arg Lys Val Arg Gly Leu Ile Phe Gly Ala Arg
 225                 230                 235                 240
 Thr Leu Glu Pro Ala Cys Leu Asp Thr Asp Pro Gly Leu Ala Ser Arg
                 245                 250                 255    
 Cys Leu Ser Ser Leu Leu Trp Val Ile Asp Leu Leu Val Pro Ala Ser
             260                 265                 270        
 Leu Gly Cys Tyr Arg Asn Gly Cys Val Gly Asn Met Lys Ser Ile Trp
         275                 280                 285            
 Asn Val Leu Cys Val Ser Tyr Asp Lys Asn Leu Leu Glu Leu Pro Arg
     290                 295                 300                
 Thr Tyr Phe Ile Phe Glu Arg Phe Leu Asn Phe Phe Leu Glu Lys Tyr
 305                 310                 315                 320
 Lys Arg Pro Val Cys Asp Thr Asp Gln Trp Glu Phe Ile Asn Gly Trp
                 325                 330                 335    
 Tyr Val Leu Val Ile Ile Ser Asp Leu Met Thr Ile Ile Gly Ser Ile
             340                 345                 350        
 Leu Lys Met Glu Ile Lys Ala Lys Val Leu Ile Leu Thr Met Gln Ala
         355                 360                 365            
 Ser Leu Pro Lys Val Leu Arg Phe Cys Ala Cys Ala Gly Met Ile Tyr
     370                 375                 380                
 Leu Gly Tyr Thr Phe Cys Gly Trp Ile Val Leu Gly Pro Tyr His Asp
 385                 390                 395                 400
 Lys Asp Ile Glu Phe Glu Asn Leu Asn Thr Val Ala Glu Cys Leu Phe
                 405                 410                 415    
 Ser Leu Val Asn Gly Asp Asp Met Phe Ala Thr Phe Ala Gln Ile Gln
             420                 425                 430        
 Gln Lys Ser Ile Leu Val Trp Leu Phe Ser Arg Leu Tyr Leu Tyr Ser
         435                 440                 445            
 Phe Ile Ser Leu Phe Ile Tyr Met Ile Leu Ser Leu Phe Ile Ala Leu
     450                 455                 460                
 Ile Thr Asp Ser Tyr Asp Thr Ile Lys Tyr Val Val Gln Ala Ile Phe
 465                 470                 475                 480
 Leu Asp Glu Ser Arg Lys Leu Pro Cys Glu Glu Ala Val Gln Val Leu
                 485                 490                 495    
 Ala Tyr Pro Cys Thr Pro Val Ala Leu Pro Cys Leu Ala Val Leu Cys
             500                 505                 510        
 Leu Leu Phe Val Arg Thr Cys Arg Glu Met Val
         515                 520            



      <210> 1130
      <211> 132
      <212> PRT
      <213> Homo sapiens


      <400> 1130
 Met Cys Ser Ala Gly Glu Leu Leu Arg Gly Gly Asp Gly Gly Glu Arg
   1               5                  10                  15    
 Asp Glu Asp Gly Asp Ala Leu Ala Glu Arg Glu Ala Ala Gly Thr Glu
              20                  25                  30        
 Trp Asp Pro Gly Ala Ser Pro Arg Arg Arg Gly Gln Arg Pro Lys Glu
          35                  40                  45            
 Ser Glu Gln Asp Val Glu Asp Ser Gln Asn His Thr Gly Glu Pro Val
      50                  55                  60                
 Gly Asp Asp Tyr Lys Lys Met Gly Thr Leu Phe Gly Glu Leu Asn Lys
  65                  70                  75                  80
 Asn Leu Ile Asn Met Gly Phe Thr Arg Met Tyr Phe Gly Glu Arg Ile
                  85                  90                  95    
 Val Glu Pro Val Ile Val Ile Phe Phe Trp Val Met Leu Trp Phe Leu
             100                 105                 110        
 Gly Leu Gln Ala Leu Gly Leu Val Ala Val Leu Cys Leu Val Ile Ile
         115                 120                 125            
 Tyr Val Gln Gln
     130        



      <210> 1131
      <211> 1210
      <212> PRT
      <213> Homo sapiens


      <400> 1131
 Met Thr Arg Pro Asn Ala Leu Asp Arg Cys Arg Gly Lys Leu Leu Val
   1               5                  10                  15    
 His Ser Leu Asn Leu Leu Ala Lys Gln Gly Leu Arg Leu Leu Arg Gly
              20                  25                  30        
 Leu Arg Arg Arg Asn Val Gln Lys Lys Val Ala Leu Ala Lys Lys Leu
          35                  40                  45            
 Leu Ala Lys Leu Arg Phe Leu Ala Glu Glu Pro Gln Pro Pro Leu Pro
      50                  55                  60                
 Asp Val Leu Val Trp Met Leu Ser Gly Gln Arg Arg Val Ala Trp Ala
  65                  70                  75                  80
 Arg Ile Pro Ala Gln Asp Val Leu Phe Ser Val Val Glu Glu Glu Arg
                  85                  90                  95    
 Gly Arg Asp Cys Gly Lys Ile Gln Ser Leu Met Leu Thr Ala Pro Gly
             100                 105                 110        
 Ala Ala Pro Gly Glu Val Cys Ala Lys Leu Glu Leu Phe Leu Arg Leu
         115                 120                 125            
 Gly Leu Gly Lys Gln Ala Lys Ala Cys Thr Ser Glu Leu Pro Pro Asp
     130                 135                 140                
 Leu Leu Pro Glu Pro Ser Ala Gly Leu Pro Ser Ser Leu His Arg Asp
 145                 150                 155                 160
 Asp Phe Ser Tyr Phe Gln Leu Arg Ala His Leu Tyr Gln Ala Arg Gly
                 165                 170                 175    
 Val Leu Ala Ala Asp Asp Ser Gly Leu Ser Asp Pro Phe Ala Arg Val
             180                 185                 190        
 Leu Ile Ser Thr Gln Cys Gln Thr Thr Arg Val Leu Glu Gln Thr Leu
         195                 200                 205            
 Ser Pro Leu Trp Asp Glu Leu Leu Val Phe Glu Gln Leu Ile Val Asp
     210                 215                 220                
 Gly Arg Arg Glu His Leu Gln Glu Glu Pro Pro Leu Val Ile Ile Asn
 225                 230                 235                 240
 Val Phe Asp His Asn Lys Phe Gly Pro Pro Val Phe Leu Gly Arg Ala
                 245                 250                 255    
 Leu Ala Ala Pro Arg Val Lys Leu Met Glu Asp Pro Tyr Gln Arg Pro
             260                 265                 270        
 Glu Leu Gln Phe Phe Pro Leu Arg Lys Gly Pro Trp Ala Ala Gly Glu
         275                 280                 285            
 Leu Ile Ala Ala Phe Gln Leu Ile Glu Leu Asp Tyr Ser Gly Arg Leu
     290                 295                 300                
 Glu Pro Ser Val Pro Ser Glu Val Glu Pro Gln Asp Leu Ala Pro Leu
 305                 310                 315                 320
 Val Glu Pro His Ser Gly Arg Leu Ser Leu Pro Pro Asn Val Cys Pro
                 325                 330                 335    
 Val Leu Arg Glu Phe Arg Val Glu Val Leu Phe Trp Gly Leu Arg Gly
             340                 345                 350        
 Leu Gly Arg Val His Leu Leu Glu Val Glu Gln Pro Gln Val Val Leu
         355                 360                 365            
 Glu Val Ala Gly Gln Gly Val Glu Ser Glu Val Leu Ala Ser Tyr Arg
     370                 375                 380                
 Glu Ser Pro Asn Phe Thr Glu Leu Val Arg His Leu Thr Val Val Phe
 385                 390                 395                 400
 Lys Asp Thr Ala Pro Leu Phe His Pro Gln Asp Leu Pro Glu Gln Pro
                 405                 410                 415    
 Tyr Leu Gln Pro Pro Leu Ser Ile Leu Val Ile Glu Arg Arg Ala Phe
             420                 425                 430        
 Gly His Thr Val Leu Val Gly Ser His Ile Val Pro His Met Leu Arg
         435                 440                 445            
 Phe Thr Phe Arg Gly His Glu Asp Pro Pro Glu Glu Glu Gly Glu Met
     450                 455                 460                
 Glu Glu Thr Gly Asp Met Met Pro Lys Gly Pro Gln Gly Gln Lys Ser
 465                 470                 475                 480
 Leu Asp Pro Phe Leu Ala Glu Ala Gly Ile Ser Arg Gln Leu Leu Lys
                 485                 490                 495    
 Pro Pro Leu Lys Lys Leu Pro Leu Gly Gly Leu Leu Asn Gln Gly Pro
             500                 505                 510        
 Gly Leu Glu Glu Asp Ile Pro Asp Pro Glu Glu Leu Asp Trp Gly Ser
         515                 520                 525            
 Lys Tyr Tyr Ala Ser Leu Gln Glu Leu Gln Gly Gln His Asn Phe Asp
     530                 535                 540                
 Glu Asp Glu Met Asp Asp Pro Gly Asp Ser Asp Gly Val Asn Leu Ile
 545                 550                 555                 560
 Ser Met Val Gly Glu Ile Gln Asp Gln Gly Glu Ala Glu Val Lys Gly
                 565                 570                 575    
 Thr Val Ser Pro Lys Lys Ala Val Ala Thr Leu Lys Ile Tyr Asn Arg
             580                 585                 590        
 Ser Leu Glu Glu Glu Phe Asn His Phe Glu Asp Trp Leu Asn Val Phe
         595                 600                 605            
 Pro Leu Tyr Arg Gly Gln Gly Gly Gln Asp Gly Gly Gly Glu Glu Glu
     610                 615                 620                
 Gly Ser Gly His Leu Val Gly Lys Phe Lys Gly Ser Phe Leu Ile Tyr
 625                 630                 635                 640
 Pro Glu Ser Glu Ala Val Leu Phe Ser Glu Pro Gln Ile Ser Arg Gly
                 645                 650                 655    
 Ile Pro Gln Asn Arg Pro Ile Lys Leu Leu Val Arg Val Tyr Val Val
             660                 665                 670        
 Lys Ala Thr Asn Leu Ala Pro Ala Asp Pro Asn Gly Lys Ala Asp Pro
         675                 680                 685            
 Tyr Val Val Val Ser Ala Gly Arg Glu Arg Gln Asp Thr Lys Glu Arg
     690                 695                 700                
 Tyr Ile Pro Lys Gln Leu Asn Pro Ile Phe Gly Glu Ile Leu Glu Leu
 705                 710                 715                 720
 Ser Ile Ser Leu Pro Ala Glu Thr Glu Leu Thr Val Ala Val Phe Asp
                 725                 730                 735    
 His Asp Leu Val Gly Ser Asp Asp Leu Ile Gly Glu Thr His Ile Asp
             740                 745                 750        
 Leu Glu Asn Arg Phe Tyr Ser His His Arg Ala Asn Cys Gly Leu Ala
         755                 760                 765            
 Ser Gln Tyr Glu Val Asp Gly Tyr Asn Ala Trp Arg Asp Ala Phe Trp
     770                 775                 780                
 Pro Ser Gln Ile Leu Ala Gly Leu Cys Gln Arg Cys Gly Leu Pro Ala
 785                 790                 795                 800
 Pro Glu Tyr Arg Ala Gly Ala Val Lys Val Gly Ser Lys Val Phe Leu
                 805                 810                 815    
 Thr Pro Pro Glu Thr Leu Pro Pro Gly Ser Ser Ser Pro Thr Val Ala
             820                 825                 830        
 Ser Gly Asp Pro Glu Glu Ala Gln Ala Leu Leu Val Leu Arg Arg Trp
         835                 840                 845            
 Gln Glu Met Pro Gly Phe Gly Ile Gln Leu Val Pro Glu His Val Glu
     850                 855                 860                
 Thr Arg Pro Leu Tyr His Pro His Ser Pro Gly Leu Leu Gln Gly Ser
 865                 870                 875                 880
 Leu His Met Trp Ile Asp Ile Phe Pro Gln Asp Val Pro Ala Pro Pro
                 885                 890                 895    
 Pro Val Asp Ile Lys Pro Arg Gln Pro Ile Ser Tyr Glu Leu Arg Val
             900                 905                 910        
 Val Ile Trp Asn Thr Glu Asp Val Val Leu Asp Asp Glu Asn Pro Leu
         915                 920                 925            
 Thr Gly Glu Met Ser Ser Asp Ile Tyr Val Lys Ser Trp Val Lys Gly
     930                 935                 940                
 Leu Glu His Asp Lys Gln Glu Thr Asp Val His Phe Asn Ser Leu Thr
 945                 950                 955                 960
 Gly Glu Gly Asn Phe Asn Trp Arg Phe Val Phe Arg Phe Asp Tyr Leu
                 965                 970                 975    
 Pro Thr Glu Arg Glu Val Ser Val Trp Arg Arg Ser Gly Pro Phe Ala
             980                 985                 990        
 Leu Glu Glu Ala Glu Phe Arg Gln Pro Ala Val Leu Val Leu Gln Val
         995                1000                1005            
 Trp Asp Tyr Asp Arg Ile Ser Ala Asn Asp Phe Leu Gly Ser Leu Glu
    1010                1015                1020                
 Leu Gln Leu Pro Asp Met Val Arg Gly Ala Arg Gly Pro Glu Leu Cys
1025                1030                1035                1040
 Ser Val Gln Leu Ala Arg Asn Gly Ala Gly Pro Arg Cys Asn Leu Phe
                1045                1050                1055    
 Arg Cys Arg Arg Leu Arg Gly Trp Trp Pro Val Val Lys Leu Lys Glu
            1060                1065                1070        
 Ala Glu Asp Val Glu Arg Glu Ala Gln Glu Ala Gln Ala Gly Lys Lys
        1075                1080                1085            
 Lys Arg Lys Gln Arg Arg Arg Lys Gly Arg Pro Glu Asp Leu Glu Phe
    1090                1095                1100                
 Thr Asp Met Gly Gly Asn Val Tyr Ile Leu Thr Gly Lys Val Glu Ala
1105                1110                1115                1120
 Glu Phe Glu Leu Leu Thr Val Glu Glu Ala Glu Lys Arg Pro Val Gly
                1125                1130                1135    
 Lys Gly Arg Lys Gln Pro Glu Pro Leu Glu Lys Pro Ser Arg Pro Lys
            1140                1145                1150        
 Thr Ser Phe Asn Trp Phe Val Asn Pro Leu Lys Thr Phe Val Phe Phe
        1155                1160                1165            
 Ile Trp Arg Arg Tyr Trp Arg Thr Leu Val Leu Leu Leu Leu Val Leu
    1170                1175                1180                
 Leu Thr Val Phe Leu Leu Leu Val Phe Tyr Thr Ile Pro Gly Gln Ile
1185                1190                1195                1200
 Ser Gln Val Ile Phe Arg Pro Leu His Lys
                1205                1210



      <210> 1132
      <211> 237
      <212> PRT
      <213> Homo sapiens


      <400> 1132
 Met Asn His Arg Ala Pro Ala Asn Gly Arg Tyr Lys Pro Thr Cys Tyr
   1               5                  10                  15    
 Glu His Ala Ala Asn Cys Tyr Thr His Ala Phe Leu Ile Val Pro Ala
              20                  25                  30        
 Ile Val Gly Ser Ala Leu Leu His Arg Leu Ser Asp Asp Cys Trp Glu
          35                  40                  45            
 Lys Ile Thr Ala Trp Ile Tyr Gly Met Gly Leu Cys Ala Leu Phe Ile
      50                  55                  60                
 Val Ser Thr Val Phe His Ile Val Ser Trp Lys Lys Ser His Leu Arg
  65                  70                  75                  80
 Leu Asn Leu Arg Glu Leu Gly Pro Leu Ala Ser His Met Arg Trp Phe
                  85                  90                  95    
 Ile Trp Leu Met Ala Ala Gly Gly Thr Ile Tyr Val Phe Leu Tyr His
             100                 105                 110        
 Glu Lys Tyr Lys Val Val Glu Leu Phe Phe Tyr Leu Thr Met Gly Phe
         115                 120                 125            
 Ser Pro Ala Leu Val Val Thr Ser Met Tyr Arg Thr Val Ile Leu Glu
     130                 135                 140                
 Gly Arg Glu Thr Lys Lys Met Ser Phe Glu Phe Thr Pro Val Val Ser
 145                 150                 155                 160
 Leu Glu Thr Leu Ser Lys Gln Gln Gln Lys Glu Asn Asn Thr Asp Gly
                 165                 170                 175    
 Leu Gln Glu Leu Ala Cys Gly Gly Leu Ile Tyr Cys Leu Gly Val Val
             180                 185                 190        
 Phe Phe Lys Ser Asp Gly Ile Ile Pro Phe Ala His Ala Ile Trp His
         195                 200                 205            
 Leu Phe Val Ala Thr Ala Ala Ala Val His Tyr Tyr Ala Ile Trp Lys
     210                 215                 220                
 Tyr Leu Tyr Arg Ser Pro Thr Asp Phe Met Arg His Leu
 225                 230                 235        



      <210> 1133
      <211> 378
      <212> PRT
      <213> Homo sapiens


      <400> 1133
 Met Glu Phe Cys Asp Thr Val Thr Gly Gln Glu Ala Gln Ser Lys Arg
   1               5                  10                  15    
 Arg Gln Asp Thr Ala Arg Ser Gly Arg Arg Pro Ala Ser Asn Pro Asp
              20                  25                  30        
 Ile His Ala Val Ser Phe Leu Gln Ala Leu Arg Gln Gly Ser Gly Arg
          35                  40                  45            
 Pro Pro Leu Gly Trp Trp Gly Pro Thr Gly Ser Ser Thr Arg Asn Met
      50                  55                  60                
 Glu Ser Gly Asn Gln Ser Thr Val Thr Glu Phe Ile Phe Thr Gly Phe
  65                  70                  75                  80
 Pro Gln Leu Gln Asp Gly Ser Leu Leu Tyr Phe Phe Pro Leu Leu Phe
                  85                  90                  95    
 Ile Tyr Thr Phe Ile Ile Ile Asp Asn Leu Leu Ile Phe Ser Ala Val
             100                 105                 110        
 Arg Leu Asp Thr His Leu His Asn Pro Met Tyr Asn Phe Ile Ser Ile
         115                 120                 125            
 Phe Ser Phe Leu Glu Ile Trp Tyr Thr Thr Ala Thr Ile Pro Lys Met
     130                 135                 140                
 Leu Ser Asn Leu Ile Ser Glu Lys Lys Ala Ile Ser Met Thr Gly Cys
 145                 150                 155                 160
 Ile Leu Gln Met Tyr Phe Phe His Ser Leu Glu Asn Ser Glu Gly Ile
                 165                 170                 175    
 Leu Leu Thr Thr Met Ala Ile Asp Arg Tyr Val Ala Ile Cys Asn Pro
             180                 185                 190        
 Leu Arg Tyr Gln Met Ile Met Thr Pro Arg Leu Cys Ala Gln Leu Ser
         195                 200                 205            
 Ala Gly Ser Cys Leu Phe Gly Phe Leu Ile Leu Leu Pro Glu Ile Val
     210                 215                 220                
 Met Ile Ser Thr Leu Pro Phe Cys Gly Pro Asn Gln Ile His Gln Ile
 225                 230                 235                 240
 Phe Cys Asp Leu Val Pro Val Leu Ser Leu Ala Cys Thr Asp Thr Ser
                 245                 250                 255    
 Met Ile Leu Ile Glu Asp Val Ile His Ala Val Ala Ile Val Phe Ser
             260                 265                 270        
 Val Leu Ile Ile Ala Leu Ser Tyr Ile Arg Ile Ile Thr Val Ile Leu
         275                 280                 285            
 Arg Ile Pro Ser Val Glu Gly Arg Gln Lys Ala Phe Ser Thr Cys Ala
     290                 295                 300                
 Ala His Leu Ser Val Phe Leu Met Phe Tyr Gly Ser Val Ser Leu Met
 305                 310                 315                 320
 Tyr Leu Arg Phe Ser Ala Thr Phe Pro Pro Ile Leu Asp Thr Ala Val
                 325                 330                 335    
 Ala Leu Met Phe Ala Val Leu Ala Pro Phe Phe Asn Pro Ile Ile Tyr
             340                 345                 350        
 Ser Phe Arg Asn Lys Asp Met Lys Ile Ala Ile Lys Lys Leu Phe Cys
         355                 360                 365            
 Pro Gln Lys Met Val Asn Leu Ser Val Asp
     370                 375            



      <210> 1134
      <211> 395
      <212> PRT
      <213> Homo sapiens


      <400> 1134
 Met Val Cys Gln Leu Arg Ser Arg His Met Gln Glu Leu Leu Val Thr
   1               5                  10                  15    
 Thr Cys Ser Leu Lys Lys Gln Glu Ala Ser Thr Asn Leu Lys Asp Lys
              20                  25                  30        
 Thr Trp Phe Lys His Leu Gly Thr Gly Gly Glu Ala Ala Leu Leu Leu
          35                  40                  45            
 Lys Ser Ser Thr Trp Pro Met Ala Leu Trp Ser Thr Arg Gly Ser Lys
      50                  55                  60                
 Met Val Ser Trp Ser Val Ile Ala Lys Ile Gln Glu Ile Trp Cys Glu
  65                  70                  75                  80
 Glu Asp Glu Arg Lys Met Val Arg Glu Phe Leu Ala Glu Phe Met Ser
                  85                  90                  95    
 Thr Tyr Val Met Met Val Phe Gly Leu Gly Ser Val Ala His Met Val
             100                 105                 110        
 Leu Asn Lys Thr Tyr Gly Ser Tyr Leu Gly Val Asn Leu Gly Phe Gly
         115                 120                 125            
 Phe Gly Val Thr Met Gly Val His Val Ala Gly Arg Ile Ser Gly Ala
     130                 135                 140                
 His Met Asn Ala Ala Val Thr Phe Thr Asn Cys Ala Leu Gly Arg Val
 145                 150                 155                 160
 Pro Trp Arg Lys Phe Pro Val His Val Leu Gly Gln Phe Leu Gly Ser
                 165                 170                 175    
 Phe Leu Ala Ala Ala Thr Ile Tyr Ser Leu Phe Tyr Ser Lys Cys Ala
             180                 185                 190        
 Ala Trp Glu Trp Leu Thr Arg Met Leu Gln Leu Cys Leu Phe Thr Ile
         195                 200                 205            
 Thr Asp Gln Glu Asn Asn Pro Ala Leu Pro Gly Thr His Ala Leu Val
     210                 215                 220                
 Ile Ser Ile Leu Val Val Ile Ile Arg Val Ser His Gly Ile Asn Thr
 225                 230                 235                 240
 Gly Tyr Ala Ile Asn Pro Ser Arg Asp Pro Pro Pro Ser Ile Phe Thr
                 245                 250                 255    
 Phe Ile Ala Gly Trp Gly Lys Gln Val Phe Ser Leu Gly Met Thr Pro
             260                 265                 270        
 Leu Leu Asn Gln Ser Ser Pro Lys Val Asp Glu Gly Ala Val Leu Gly
         275                 280                 285            
 Ile Ser Pro Leu Ser Arg Pro Leu Pro Leu Ala Cys Ser Asp Gly Glu
     290                 295                 300                
 Asn Trp Trp Trp Val Pro Val Val Ala Pro Leu Leu Gly Ala Ser Leu
 305                 310                 315                 320
 Gly Gly Ile Ile Tyr Leu Val Phe Ile Gly Ser Thr Ile Pro Arg Glu
                 325                 330                 335    
 Pro Leu Lys Leu Glu Asp Ser Val Ala Tyr Glu Asp His Gly Ile Thr
             340                 345                 350        
 Val Leu Pro Lys Met Gly Ser His Glu Pro Met Ile Ser Pro Leu Thr
         355                 360                 365            
 Leu Ile Ser Val Ser Leu Ala Asn Arg Ser Ser Val His Ser Ala Pro
     370                 375                 380                
 Pro Leu His Glu Ser Met Ala Leu Glu His Phe
 385                 390                 395



      <210> 1135
      <211> 540
      <212> PRT
      <213> Homo sapiens


      <400> 1135
 Met Leu Pro Ala Pro Asp Ser Asn Thr Gly Ser Ser Ser Glu Asn Lys
   1               5                  10                  15    
 Asp Ala Asp Leu Gly Arg Cys Leu Thr Ala Asp Gly Leu Tyr Leu Tyr
              20                  25                  30        
 Thr Thr Asn Ser Val Gly Arg Gly Val Ser Lys Leu Gly Ser Gly Leu
          35                  40                  45            
 His Gly Thr Leu Arg Gly Phe Val Tyr Cys Arg Asn Glu Glu Leu Glu
      50                  55                  60                
 Pro Gly Trp Val Ala Phe Gly Ser Gly Ser Leu Leu His Arg Pro Val
  65                  70                  75                  80
 Ser Phe Asp Asn Lys Pro His Ser Leu Phe Gln Val Ile Asp Gln Asn
                  85                  90                  95    
 Thr Leu Gln Val Cys Gln Val Val Pro Met Pro Ala Asn His Leu Pro
             100                 105                 110        
 Ile Gly Ser Thr Met Ser Thr Val His Leu Ser Ser Asp Gly Thr Tyr
         115                 120                 125            
 Phe Tyr Trp Ile Trp Ser Pro Ala Ser Leu Asn Glu Lys Thr Pro Lys
     130                 135                 140                
 Gly His Ser Val Phe Met Asp Ile Phe Glu Leu Val Val Glu Asn Gly
 145                 150                 155                 160
 Val Phe Val Ala Asn Pro Leu Gln Glu Arg Thr Ile Leu Met Arg Lys
                 165                 170                 175    
 Glu Gly Glu Ser Ala Lys Ser Ile Asn Glu Met Leu Leu Ser Arg Leu
             180                 185                 190        
 Ser Arg Tyr Arg Ala Ser Pro Ser Ala Thr Leu Ala Ala Leu Thr Gly
         195                 200                 205            
 Ser Thr Ile Ser Asn Thr Leu Lys Glu Asp Gln Ala Ala Asn Thr Ser
     210                 215                 220                
 Cys Gly Leu Pro Leu Lys Met Leu Arg Lys Thr Pro Ile Tyr Thr Cys
 225                 230                 235                 240
 Gly Thr Tyr Leu Val Met Leu Val Pro Pro Pro Gly Gly Ser Gly Ser
                 245                 250                 255    
 Ser Ala Thr Arg Ser Leu Phe Gly Gly Thr Ser Gly Leu Ser Ser Leu
             260                 265                 270        
 Lys Ile Leu Ala Ser Ser Leu Val Tyr Asn Ile Ser Asp Gly Gln Phe
         275                 280                 285            
 Thr Ser Arg Ala Asp Leu Ile Asp Ala Ala Gly Ser Ser Leu Gly Arg
     290                 295                 300                
 Gly Ala Leu Val Pro Gly Leu Gly Ala Cys Tyr Asp Thr Val Asn Asn
 305                 310                 315                 320
 Met Leu Trp Thr Cys Ser Asn Asp Tyr Ile Asp Gln Trp Cys Asn Pro
                 325                 330                 335    
 Gly Asn Gln Ala Phe His Tyr Val Cys Gln Arg Leu Gly Val Ser His
             340                 345                 350        
 Ile Ile Thr Glu Pro Lys Glu Glu Ala Ile Thr Thr Asn Glu Val Ile
         355                 360                 365            
 Asn Gln Leu Leu His His Val Gly Ala Met Cys Ile His Gln Leu Asn
     370                 375                 380                
 Leu Leu Ala Thr Asn Pro Asn Leu Pro Ile Thr Ser Val Leu Gly Lys
 385                 390                 395                 400
 Gln His Pro Ile Glu Ala His His Leu Ser Ser Ile Cys Asp Ile Met
                 405                 410                 415    
 Glu Lys Ala Met Val Asn Gly Asp Thr Cys Ile Ile Arg Cys Ile Leu
             420                 425                 430        
 Val Val Phe Gln Val Val Phe Lys Phe Phe Phe Ser Pro Gln Thr Glu
         435                 440                 445            
 Arg Asn Arg Asp Ile Ile Arg Arg Ser Gly Leu Leu Leu Trp Gln Leu
     450                 455                 460                
 Leu Met Ala Pro Lys Asp Gln Ile Cys Pro Glu Ile Gln Lys Glu Val
 465                 470                 475                 480
 Cys Leu Ala Ile Arg Leu Trp Phe Gln Ile Ser Cys Thr Pro Gly Glu
                 485                 490                 495    
 Thr Asp Ile Thr Asn Leu Leu Lys Leu Val Leu Thr Glu Gly Arg Glu
             500                 505                 510        
 Lys Gln Trp Thr Leu Pro Ser Tyr Gly Asn Val Ile Leu Thr Ile Leu
         515                 520                 525            
 Cys Glu Gln Ser Gln Asn Asn Arg Phe Gly Ser Gly
     530                 535                 540



      <210> 1136
      <211> 562
      <212> PRT
      <213> Homo sapiens


      <400> 1136
 Met Thr Gln Asn Lys Leu Lys Leu Cys Ser Lys Ala Asn Val Tyr Thr
   1               5                  10                  15    
 Glu Val Pro Asp Gly Gly Trp Gly Trp Ala Val Ala Val Ser Phe Phe
              20                  25                  30        
 Phe Val Glu Val Phe Thr Tyr Gly Ile Ile Lys Thr Phe Gly Val Phe
          35                  40                  45            
 Phe Asn Asp Leu Met Asp Ser Phe Asn Glu Ser Asn Ser Arg Ile Ser
      50                  55                  60                
 Trp Ile Ile Ser Ile Cys Val Phe Val Leu Thr Phe Ser Ala Pro Leu
  65                  70                  75                  80
 Ala Thr Val Leu Ser Asn Arg Phe Gly His Arg Leu Val Val Met Leu
                  85                  90                  95    
 Gly Gly Leu Leu Val Ser Thr Gly Met Val Ala Ala Ser Phe Ser Gln
             100                 105                 110        
 Glu Val Ser His Met Tyr Val Ala Ile Gly Ile Ile Ser Gly Leu Gly
         115                 120                 125            
 Tyr Cys Phe Ser Phe Leu Pro Thr Val Thr Ile Leu Ser Gln Tyr Phe
     130                 135                 140                
 Gly Lys Arg Arg Ser Ile Val Thr Ala Val Ala Ser Thr Gly Glu Cys
 145                 150                 155                 160
 Phe Ala Val Phe Ala Phe Ala Pro Ala Ile Met Ala Leu Lys Glu Arg
                 165                 170                 175    
 Ile Gly Trp Arg Tyr Ser Leu Leu Phe Val Gly Leu Leu Gln Leu Asn
             180                 185                 190        
 Ile Val Ile Phe Gly Ala Leu Leu Arg Pro Ile Ile Ile Arg Gly Pro
         195                 200                 205            
 Ala Ser Pro Lys Ile Val Ile Gln Glu Asn Arg Lys Glu Ala Gln Tyr
     210                 215                 220                
 Met Leu Glu Asn Glu Lys Thr Arg Thr Ser Ile Asp Ser Ile Asp Ser
 225                 230                 235                 240
 Gly Val Glu Leu Thr Thr Ser Pro Lys Asn Val Pro Thr His Thr Asn
                 245                 250                 255    
 Leu Glu Leu Glu Pro Lys Ala Asp Met Gln Gln Val Leu Val Lys Thr
             260                 265                 270        
 Ser Pro Arg Pro Ser Glu Lys Lys Ala Pro Leu Leu Asp Phe Ser Ile
         275                 280                 285            
 Leu Lys Glu Lys Ser Phe Ile Cys Tyr Ala Leu Phe Gly Leu Phe Ala
     290                 295                 300                
 Thr Leu Gly Phe Phe Ala Pro Ser Leu Tyr Ile Ile Pro Leu Gly Ile
 305                 310                 315                 320
 Ser Leu Gly Ile Asp Gln Asp Arg Ala Ala Phe Leu Leu Ser Thr Met
                 325                 330                 335    
 Ala Ile Ala Glu Val Phe Gly Arg Ile Gly Ala Gly Phe Val Leu Asn
             340                 345                 350        
 Arg Glu Pro Ile Arg Lys Ile Tyr Ile Glu Leu Ile Cys Val Ile Leu
         355                 360                 365            
 Leu Thr Val Ser Leu Phe Ala Phe Thr Phe Ala Thr Glu Phe Trp Gly
     370                 375                 380                
 Leu Met Ser Cys Ser Ile Phe Phe Gly Phe Met Val Gly Thr Ile Gly
 385                 390                 395                 400
 Gly Thr His Ile Pro Leu Leu Ala Glu Asp Asp Val Val Gly Ile Glu
                 405                 410                 415    
 Lys Met Ser Ser Ala Ala Gly Val Tyr Ile Phe Ile Gln Ser Ile Ala
             420                 425                 430        
 Gly Leu Ala Gly Pro Pro Leu Ala Gly Leu Leu Val Asp Gln Ser Lys
         435                 440                 445            
 Ile Tyr Ser Arg Ala Phe Tyr Ser Cys Ala Ala Gly Met Ala Leu Ala
     450                 455                 460                
 Ala Val Cys Leu Ala Leu Val Arg Pro Cys Lys Met Gly Leu Cys Gln
 465                 470                 475                 480
 His His His Ser Gly Glu Thr Lys Val Val Ser His Arg Gly Lys Thr
                 485                 490                 495    
 Leu Gln Asp Ile Pro Glu Asp Phe Leu Glu Met Asp Leu Ala Lys Asn
             500                 505                 510        
 Glu His Arg Val His Val Gln Met Glu Pro Val Gln Asn Lys Lys Ser
         515                 520                 525            
 Gly Lys Arg Thr Tyr Asn Phe Pro Phe His Val Thr Thr His Pro Asn
     530                 535                 540                
 Gln Asn Tyr Phe Asn Asp Tyr Pro Phe Pro Thr Trp Lys Ile Arg Arg
 545                 550                 555                 560
 Glu Thr
        



      <210> 1137
      <211> 155
      <212> PRT
      <213> Homo sapiens


      <400> 1137
 Met Phe Glu Ser Lys Asn Gly Pro Glu Tyr Ala Ser Phe Phe Pro Val
   1               5                  10                  15    
 Met Gly Ala Ser Ala Ala Met Val Phe Ser Ala Leu Gly Pro Ala Tyr
              20                  25                  30        
 Gly Ser Thr Lys Ser Gly Thr Gly Ile Ser Ala Met Ser Val Ile Arg
          35                  40                  45            
 Pro Glu Gln Ile Met Lys Ser Ile Ile Pro Val Val Met Ala Gly Ile
      50                  55                  60                
 Ile Ala Ile Tyr Gly Leu Val Val Ala Val Leu Ile Ala Asn Ser Leu
  65                  70                  75                  80
 Asn Asp Asp Ile Ser Leu Tyr Lys Ser Phe Leu Gln Leu Gly Ala Gly
                  85                  90                  95    
 Leu Ser Val Gly Leu Ser Gly Leu Ala Ala Gly Phe Ala Ile Gly Ile
             100                 105                 110        
 Val Gly Asp Ala Gly Val Arg Gly Thr Ala Gln Gln Pro Arg Leu Phe
         115                 120                 125            
 Val Gly Met Ile Leu Ile Leu Ile Phe Ala Glu Val Leu Gly Leu Tyr
     130                 135                 140                
 Gly Leu Ile Val Ala Leu Ile Leu Ser Thr Lys
 145                 150                 155



      <210> 1138
      <211> 327
      <212> PRT
      <213> Homo sapiens


      <400> 1138
 Met Leu Gly Pro Gln Val Trp Ser Ser Val Arg Gln Gly Leu Ser Arg
   1               5                  10                  15    
 Ser Leu Ser Arg Asn Val Gly Val Trp Ala Ser Gly Glu Gly Lys Lys
              20                  25                  30        
 Val Asp Ile Ala Gly Ile Tyr Pro Pro Val Thr Thr Pro Phe Thr Ala
          35                  40                  45            
 Thr Ala Glu Val Asp Tyr Gly Lys Leu Glu Glu Asn Leu His Lys Leu
      50                  55                  60                
 Gly Thr Phe Pro Phe Arg Gly Phe Val Val Gln Gly Ser Asn Gly Glu
  65                  70                  75                  80
 Phe Pro Phe Leu Thr Ser Ser Glu Arg Leu Glu Val Val Ser Arg Val
                  85                  90                  95    
 Arg Gln Ala Met Pro Met Asn Arg Leu Leu Leu Ala Gly Ser Gly Cys
             100                 105                 110        
 Glu Ser Thr Gln Ala Thr Val Glu Met Thr Val Ser Met Ala Gln Val
         115                 120                 125            
 Gly Ala Asp Ala Ala Met Val Val Thr Pro Cys Tyr Tyr Arg Gly Arg
     130                 135                 140                
 Met Ser Ser Ala Ala Leu Ile His His Tyr Thr Lys Val Ala Asp Leu
 145                 150                 155                 160
 Ser Pro Ile Pro Val Val Leu Tyr Ser Val Pro Ala Asn Thr Gly Leu
                 165                 170                 175    
 Asp Leu Pro Val Asp Ala Val Val Thr Leu Ser Gln His Pro Asn Ile
             180                 185                 190        
 Val Gly Met Lys Asp Ser Gly Gly Asp Val Thr Arg Ile Gly Leu Ile
         195                 200                 205            
 Val His Lys Thr Arg Lys Gln Asp Phe Gln Val Leu Ala Gly Ser Ala
     210                 215                 220                
 Gly Phe Leu Met Ala Ser Tyr Ala Leu Gly Ala Val Gly Gly Val Cys
 225                 230                 235                 240
 Ala Leu Ala Asn Val Leu Gly Ala Gln Val Cys Gln Leu Glu Arg Leu
                 245                 250                 255    
 Cys Cys Thr Gly Gln Trp Glu Asp Ala Gln Lys Leu Gln His Arg Leu
             260                 265                 270        
 Ile Glu Pro Asn Ala Ala Val Thr Arg Arg Phe Gly Ile Pro Gly Leu
         275                 280                 285            
 Lys Lys Ile Met Asp Trp Phe Gly Tyr Tyr Gly Gly Pro Cys Arg Ala
     290                 295                 300                
 Pro Leu Gln Glu Leu Ser Pro Ala Glu Glu Glu Ala Leu Arg Met Asp
 305                 310                 315                 320
 Phe Thr Ser Asn Gly Trp Leu
                 325        



      <210> 1139
      <211> 1070
      <212> PRT
      <213> Homo sapiens


      <400> 1139
 Met Ala Ala Asn Ser Thr Ser Asp Leu His Thr Pro Gly Thr Gln Leu
   1               5                  10                  15    
 Ser Val Ala Asp Ile Ile Val Ile Thr Val Tyr Phe Ala Leu Asn Val
              20                  25                  30        
 Ala Val Gly Ile Trp Ser Ser Cys Arg Ala Ser Arg Asn Thr Val Asn
          35                  40                  45            
 Gly Tyr Phe Leu Ala Gly Arg Asp Met Thr Trp Trp Pro Ile Gly Ala
      50                  55                  60                
 Ser Leu Phe Ala Ser Ser Glu Gly Ser Gly Leu Phe Ile Gly Leu Ala
  65                  70                  75                  80
 Gly Ser Gly Ala Ala Gly Gly Leu Ala Val Ala Gly Phe Glu Trp Asn
                  85                  90                  95    
 Ala Thr Tyr Val Leu Leu Ala Leu Ala Trp Val Phe Val Pro Ile Tyr
             100                 105                 110        
 Ile Ser Ser Glu Ile Val Thr Leu Pro Glu Tyr Ile Gln Lys Arg Tyr
         115                 120                 125            
 Gly Gly Gln Arg Ile Arg Met Tyr Leu Ser Val Leu Ser Leu Leu Leu
     130                 135                 140                
 Ser Val Phe Thr Lys Ile Ser Leu Asp Leu Tyr Ala Gly Ala Leu Phe
 145                 150                 155                 160
 Val His Ile Cys Leu Gly Trp Asn Phe Tyr Leu Ser Thr Ile Leu Thr
                 165                 170                 175    
 Leu Gly Ile Thr Ala Leu Tyr Thr Ile Ala Gly Gly Leu Ala Ala Val
             180                 185                 190        
 Ile Tyr Thr Asp Ala Leu Gln Thr Leu Ile Met Val Val Gly Ala Val
         195                 200                 205            
 Ile Leu Thr Ile Lys Gly Thr Ala Leu Ala Gly Arg Gly Tyr Pro Pro
     210                 215                 220                
 Cys Cys Pro Ala Val Thr Ser Ser Gly Pro Gly Lys Glu Leu Thr Gln
 225                 230                 235                 240
 Glu Leu Arg Ala Ser His Thr Arg Ile Gly Ser Ala Leu Asp Ala Phe
                 245                 250                 255    
 Asp Gln Ile Gly Gly Tyr Gly Gln Leu Glu Ala Ala Tyr Ala Gln Ala
             260                 265                 270        
 Ile Pro Ser Arg Thr Ile Ala Asn Thr Thr Cys His Leu Pro Arg Thr
         275                 280                 285            
 Asp Ala Met His Met Phe Arg Asp Pro His Thr Gly Asp Leu Pro Trp
     290                 295                 300                
 Thr Gly Met Thr Phe Gly Leu Thr Ile Met Ala Thr Trp Tyr Trp Cys
 305                 310                 315                 320
 Thr Asp Gln Val Leu Arg Leu Arg Gln Phe Gly Val Trp Asp Ser Glu
                 325                 330                 335    
 Gly Thr Arg Met Leu Leu Gly Gly Pro Ala Ile Gly His Gly Ala Gly
             340                 345                 350        
 Ile Leu Gly Gln Ser Trp Ala Ala Gly Ile Arg Lys Gln Ala Gly Tyr
         355                 360                 365            
 Leu Thr Ser Leu Gly Leu Pro Val Val Gly Ala Ser His Gly Trp Ala
     370                 375                 380                
 Ser Val Ser Gly Arg Ala Leu Asp Ala Val Ser Ser Arg Ala Val Ile
 385                 390                 395                 400
 Val Gln Arg Ser Leu Ser Ala Arg Asp Leu Asn His Ala Lys Ala Gly
                 405                 410                 415    
 Ser Ile Leu Ala Ser Tyr Leu Lys Met Leu Pro Met Gly Leu Ile Ile
             420                 425                 430        
 Met Pro Gly Met Ile Ser Arg Ala Leu Phe Pro Gly Met Pro Leu Arg
         435                 440                 445            
 Leu Thr Leu Cys Asp Met Arg Tyr Ser Ser Trp Asn Cys Arg Ser Asn
     450                 455                 460                
 Ile Ser Thr Thr Trp Pro Asp Ser Thr Glu Ile Thr Phe Arg Ser Val
 465                 470                 475                 480
 Arg Ala Ala Asp His Val Lys Leu Gln Gln Arg Glu Gly Ala Leu Val
                 485                 490                 495    
 Arg His Met Thr Leu Leu Pro Pro Pro Ser Pro Arg Ala Pro Ile Ala
             500                 505                 510        
 Ala Gly Pro Gln Thr Val Ala Thr Gly Pro Trp Asp Gln Glu Val Asn
         515                 520                 525            
 Gly Gly Arg Glu Gln Thr Pro Val Ala Gly Val Ala Pro Gly Lys Gln
     530                 535                 540                
 Pro Gln Arg Gln Ala Gly Val Gly Arg Gly Leu Gln Val Cys Thr Gln
 545                 550                 555                 560
 Pro Ala Gln Gln Glu Ala Gly His Gly Pro Gly Gln Leu Ala Leu Val
                 565                 570                 575    
 Thr Leu Tyr Pro Thr Trp Ser Thr Leu Gly Val Glu Lys Ser Asp Lys
             580                 585                 590        
 Asp Pro Gly Gly Gly Asn Ser Ser Ser Gly Tyr Val Thr Ala Trp Gln
         595                 600                 605            
 Glu Ala Leu Gly Leu Leu Asp Ser Glu Cys Leu Ala Gln Asp Ser Val
     610                 615                 620                
 Gln Ser Arg Gln Val Leu Glu Val Phe Val Asp Arg Leu Asn Asp Pro
 625                 630                 635                 640
 Cys Pro Pro Ala Thr Gln Ala Ser Glu Glu Pro Ala His Leu Glu Val
                 645                 650                 655    
 Pro Gln Val His Ala Gly Pro Leu Thr His Val Gln Glu Val Leu Asp
             660                 665                 670        
 Val Thr Leu Ile His Asp Asp Val His Gly His Phe Pro Leu Glu Ala
         675                 680                 685            
 Gly Val Gln Gln Val Leu Glu Asp Val His Gly Leu Pro Val Val Leu
     690                 695                 700                
 Thr Thr Gly Lys Asp Ala Leu Glu Leu Gln Leu Arg Glu Glu Val Ser
 705                 710                 715                 720
 Asp Val Leu Pro Leu Glu His Leu Val Glu Gly Val Pro Ala Ala Gly
                 725                 730                 735    
 His Gln Gly Leu Gln Arg Gln Pro Leu Leu Leu Ala Val Glu Glu Leu
             740                 745                 750        
 Arg Leu Gly Leu Ala Gly Ala Pro Val His Met Val Val Val Gln Thr
         755                 760                 765            
 Leu His Leu Arg Glu Gly His Gly Ala Ala Cys Pro Gly Thr Ala Ala
     770                 775                 780                
 Gly Gly Ala His Val Tyr Glu Glu Arg His Gln Val Ser Val Ser Arg
 785                 790                 795                 800
 Thr Asp Asp Val Gly Cys Val Val Pro Ser Glu Cys Leu Arg Ala Cys
                 805                 810                 815    
 Gly Ala Glu Val Gly Cys Ser Asn Ile Ala Tyr Pro Lys Leu Val Met
             820                 825                 830        
 Glu Leu Met Pro Ile Gly Leu Arg Gly Leu Met Ile Ala Val Met Leu
         835                 840                 845            
 Ala Ala Leu Met Ser Ser Leu Thr Ser Ile Phe Asn Ser Ser Ser Thr
     850                 855                 860                
 Leu Phe Thr Met Asp Ile Trp Arg Arg Leu Arg Pro Arg Ser Gly Glu
 865                 870                 875                 880
 Arg Glu Leu Leu Leu Val Gly Arg Leu Val Ile Val Ala Leu Ile Gly
                 885                 890                 895    
 Val Ser Val Ala Trp Ile Pro Val Leu Gln Asp Ser Asn Ser Gly Gln
             900                 905                 910        
 Leu Phe Ile Tyr Met Gln Ser Val Thr Ser Ser Leu Ala Pro Pro Val
         915                 920                 925            
 Thr Ala Val Phe Val Leu Gly Val Phe Trp Arg Arg Ala Asn Glu Gln
     930                 935                 940                
 Gly Ala Phe Trp Gly Leu Ile Ala Gly Leu Val Val Gly Ala Thr Arg
 945                 950                 955                 960
 Leu Val Leu Glu Phe Leu Asn Pro Ala Pro Pro Cys Gly Glu Pro Asp
                 965                 970                 975    
 Thr Arg Pro Ala Val Leu Gly Ser Ile His Tyr Leu His Phe Ala Val
             980                 985                 990        
 Ala Leu Phe Ala Leu Ser Gly Ala Val Val Val Ala Gly Ser Leu Leu
         995                1000                1005            
 Thr Pro Pro Pro Gln Ser Val Gln Ile Glu Asn Leu Thr Trp Trp Thr
    1010                1015                1020                
 Leu Ala Gln Asp Val Pro Leu Gly Thr Lys Ala Gly Asp Gly Gln Thr
1025                1030                1035                1040
 Pro Gln Lys His Ala Phe Trp Ala Arg Val Cys Gly Phe Asn Ala Ile
                1045                1050                1055    
 Leu Leu Met Cys Val Asn Ile Phe Phe Tyr Ala Tyr Phe Ala
            1060                1065                1070



      <210> 1140
      <211> 539
      <212> PRT
      <213> Homo sapiens


      <400> 1140
 Met Gly Asn Ala Gly Ser Met Asp Ser Gln Gln Thr Asp Phe Arg Ala
   1               5                  10                  15    
 His Asn Val Pro Leu Lys Leu Pro Met Pro Glu Pro Gly Glu Leu Glu
              20                  25                  30        
 Glu Arg Phe Ala Ile Val Leu Asn Ala Met Asn Leu Pro Pro Asp Lys
          35                  40                  45            
 Ala Arg Leu Leu Arg Gln Tyr Asp Asn Glu Lys Lys Trp Glu Leu Ile
      50                  55                  60                
 Cys Asp Gln Glu Arg Phe Gln Val Lys Asn Pro Pro His Thr Tyr Ile
  65                  70                  75                  80
 Gln Lys Leu Lys Gly Tyr Leu Asp Pro Ala Val Thr Arg Lys Lys Phe
                  85                  90                  95    
 Arg Arg Arg Val Gln Glu Ser Thr Gln Val Leu Arg Glu Leu Glu Ile
             100                 105                 110        
 Ser Leu Arg Thr Asn His Ile Gly Trp Val Arg Glu Phe Leu Asn Glu
         115                 120                 125            
 Glu Asn Lys Gly Leu Asp Val Leu Val Glu Tyr Leu Ser Phe Ala Gln
     130                 135                 140                
 Tyr Ala Val Thr Phe Asp Phe Glu Ser Val Glu Ser Thr Val Glu Ser
 145                 150                 155                 160
 Ser Val Asp Lys Ser Lys Pro Trp Ser Arg Ser Ile Glu Asp Leu His
                 165                 170                 175    
 Arg Gly Ser Asn Leu Pro Ser Pro Val Gly Asn Ser Val Ser Arg Ser
             180                 185                 190        
 Gly Arg His Ser Ala Leu Arg Tyr Asn Thr Leu Pro Ser Arg Arg Thr
         195                 200                 205            
 Leu Lys Asn Ser Arg Leu Val Ser Lys Lys Asp Asp Val His Val Cys
     210                 215                 220                
 Ile Met Cys Leu Arg Ala Ile Met Asn Tyr Gln Tyr Gly Phe Asn Met
 225                 230                 235                 240
 Val Met Ser His Pro His Ala Val Asn Glu Ile Ala Leu Ser Leu Asn
                 245                 250                 255    
 Asn Lys Asn Pro Arg Thr Lys Ala Leu Val Leu Glu Leu Leu Ala Ala
             260                 265                 270        
 Val Cys Leu Val Arg Gly Gly His Glu Ile Ile Leu Ser Ala Phe Asp
         275                 280                 285            
 Asn Phe Lys Glu Val Cys Gly Glu Lys Gln Arg Phe Glu Lys Leu Met
     290                 295                 300                
 Glu His Phe Arg Asn Glu Asp Asn Asn Ile Asp Phe Met Val Ala Ser
 305                 310                 315                 320
 Met Gln Phe Ile Asn Ile Val Val His Ser Val Glu Asp Met Asn Phe
                 325                 330                 335    
 Arg Val His Leu Gln Tyr Glu Phe Thr Lys Leu Gly Leu Asp Glu Tyr
             340                 345                 350        
 Leu Asp Lys Leu Lys His Thr Glu Ser Asp Lys Leu Gln Val Gln Ile
         355                 360                 365            
 Gln Ala Tyr Leu Asp Asn Val Phe Asp Val Gly Ala Leu Leu Glu Asp
     370                 375                 380                
 Ala Glu Thr Lys Asn Ala Ala Leu Glu Arg Val Glu Glu Leu Glu Glu
 385                 390                 395                 400
 Asn Ile Ser His Leu Ser Glu Lys Leu Gln Asp Thr Glu Asn Glu Ala
                 405                 410                 415    
 Met Ser Lys Ile Val Glu Leu Glu Lys Gln Leu Met Gln Arg Asn Lys
             420                 425                 430        
 Glu Leu Asp Val Val Arg Glu Ile Tyr Lys Asp Ala Asn Thr Gln Val
         435                 440                 445            
 His Thr Leu Arg Lys Met Val Lys Glu Lys Glu Glu Ala Ile Gln Arg
     450                 455                 460                
 Gln Ser Thr Leu Glu Lys Lys Ile His Glu Leu Glu Lys Gln Gly Thr
 465                 470                 475                 480
 Ile Lys Ile Gln Lys Lys Gly Asp Gly Asp Ile Ala Ile Leu Pro Val
                 485                 490                 495    
 Val Ala Ser Gly Thr Leu Ser Met Gly Ser Glu Val Val Ala Val Val
             500                 505                 510        
 Phe Asn Ser Gly Leu Ala Gly Lys Ser Thr Glu Phe Lys Pro Arg Tyr
         515                 520                 525            
 Ser Tyr Gln Lys Cys Cys Leu Ile Ser Glu Ser
     530                 535                



      <210> 1141
      <211> 299
      <212> PRT
      <213> Homo sapiens


      <400> 1141
 Met Arg Asn Asp Gln Asn Asn Gly Asp Met Lys Pro Phe Gln Asn Phe
   1               5                  10                  15    
 Thr Thr Ile Pro Ile Thr Gln Ala Leu Asn Tyr Asn Leu Ser Lys Glu
              20                  25                  30        
 Gly His Leu Glu Lys Glu Pro Trp Asn Ala Phe Ser His His Gly Pro
          35                  40                  45            
 Val Asn Val Ser Ile Asn Gly Ile Pro Cys Ile Leu Phe Trp Ala Lys
      50                  55                  60                
 Arg Ile Met Ile Lys Phe Lys Asn Gln Thr Trp Leu Asp Leu Thr Asp
  65                  70                  75                  80
 Glu Pro Phe Gly Gln Lys Val Thr Val Asp Pro Asp Asn Ser Asn Cys
                  85                  90                  95    
 Ser Glu Glu Ser Ala Arg Leu Ser Leu Lys Leu Gly Asp Ala Gly Asn
             100                 105                 110        
 Pro Arg Ser Leu Ala Ile Arg Phe Ile Leu Thr Asn Tyr Asn Lys Leu
         115                 120                 125            
 Ser Ile Gln Ser Trp Phe Ser Leu Arg Arg Val Glu Ile Ile Ser Asn
     130                 135                 140                
 Asn Ser Ile Gln Ala Val Phe Asn Pro Thr Gly Val Tyr Ala Pro Ser
 145                 150                 155                 160
 Gly Tyr Ser Tyr Arg Cys Gln Arg Val Gly Ser Leu Gln Gln Asp Gln
                 165                 170                 175    
 Ala Leu Leu Leu Pro Ser Asp Thr Asp Asp Gly Ser Ser Leu Trp Glu
             180                 185                 190        
 Val Thr Phe Ile Asp Phe Gln Ile Gln Gly Phe Ala Ile Lys Gly Gly
         195                 200                 205            
 Arg Phe Thr Lys Ala Gln Asp Cys Ala Ser Ser Phe Ser Pro Ala Phe
     210                 215                 220                
 Leu Ile Gly Leu Ala Met Ser Leu Ile Leu Leu Leu Val Leu Ala Tyr
 225                 230                 235                 240
 Ala Leu His Met Leu Ile Tyr Leu Arg Tyr Leu Asp Gln Gln Tyr Asp
                 245                 250                 255    
 Leu Ile Ala Ser Pro Ala His Phe Ser Gln Leu Lys Ala Arg Asp Thr
             260                 265                 270        
 Ala Glu Glu Lys Glu Leu Leu Arg Ser Gln Gly Ala Glu Cys Tyr Lys
         275                 280                 285            
 Leu Arg Ser Gln Gln Ile Ser Lys Ile Tyr Val
     290                 295                



      <210> 1142
      <211> 944
      <212> PRT
      <213> Homo sapiens


      <400> 1142
 Met Thr Leu Asn Gln Phe Gln Val Gln Met Leu Arg Lys Leu Glu Ala
   1               5                  10                  15    
 Ser Ala Phe Val Pro Leu Glu Leu Glu Asp His His Ala Asn Lys Ala
              20                  25                  30        
 Arg Arg Glu Asp Phe Cys Pro Arg Lys Leu Arg Gln Met His Leu Met
          35                  40                  45            
 Ile Asp Gln Leu Met Ala His Ser His Leu Arg Tyr Lys Gly Thr Leu
      50                  55                  60                
 Ser Met Leu Gln Cys Asn Val Phe Pro Gly Leu Pro Pro Asp Phe Leu
  65                  70                  75                  80
 Asp Ser Glu Val Asn Leu Phe Leu Val Pro Phe Met Asp Ser Glu Ala
                  85                  90                  95    
 Glu Ser Glu Asn Pro Pro Arg Ala Gly Thr Val Thr Leu Asn Ser Phe
             100                 105                 110        
 Gln Ser Leu Val Ser Lys Leu Arg Ser Gln Val Met Ser Met Ala Arg
         115                 120                 125            
 Pro Gln Leu Ser His Thr Ile Leu Thr Glu Lys Asn Cys Ser Gly Leu
     130                 135                 140                
 Arg Leu Leu Ile Gly Phe Thr Cys Asp Leu Val Val Ser Val Ala Lys
 145                 150                 155                 160
 Glu Gly Leu Asn Gln His Thr Leu Gly Val Pro Gly Cys Gln Ile Gln
                 165                 170                 175    
 Gly Arg Val Lys His Pro Val Asp Gly Gly Glu Gly Gly Ala Ala Glu
             180                 185                 190        
 Asp Asn His Tyr Cys Leu Gln Met Ala Gly Ile Thr Gly Phe Gly Glu
         195                 200                 205            
 Gly Asn Pro Val Ser Trp Arg Asn Gly Phe Cys Val Thr Ser Lys Asp
     210                 215                 220                
 Cys Lys Phe Gly Asn Ser Ile Tyr Ala Leu Thr Tyr Gly Val Gly Phe
 225                 230                 235                 240
 Gly Phe Cys Val Asn Thr Thr Cys Cys Gln Gly Asn Tyr Gln Glu Pro
                 245                 250                 255    
 Thr Pro Leu Ala Ala His Leu Ala Ser His Thr Leu Ser Glu Ile Leu
             260                 265                 270        
 Cys Pro Thr Cys Pro Gly Ser Tyr Leu Glu Pro Cys Asn Ser Ser Phe
         275                 280                 285            
 Tyr Met Gln Cys Pro Ser Gly Glu Ser Glu Cys Val Gln Leu Asp Leu
     290                 295                 300                
 Thr Ser Glu Glu Gly Gly Arg Asn Val Asn Val Arg Gly Cys Gly Ser
 305                 310                 315                 320
 Arg Asp Leu Cys Ser Ala Leu Asp Trp Thr His Gly Leu Ser Val Leu
                 325                 330                 335    
 Pro Arg His Trp Ala Val Glu Pro Leu Gln Pro Pro Pro Pro Arg Arg
             340                 345                 350        
 His Arg Ser Trp Gln Pro Arg Arg Cys Asp Lys Glu Ser Arg Leu Asp
         355                 360                 365            
 His Pro Ala Ala Arg Glu Ala Pro Ser Thr Cys Leu Phe Gly Thr Ser
     370                 375                 380                
 Ile Asp Gly Ala Leu Ala Pro Leu Cys Trp Gly Asn Ala Glu Thr Trp
 385                 390                 395                 400
 Lys Pro Leu Val Thr Met Ser Glu Ser Gly His Ser Gln Pro Gly Leu
                 405                 410                 415    
 Tyr Gly Ile Glu Arg Arg Arg Arg Trp Lys Glu Pro Gly Ser Gly Gly
             420                 425                 430        
 Pro Gln Asn Leu Ser Gly Pro Gly Gly Arg Glu Arg Asp Tyr Ile Ala
         435                 440                 445            
 Pro Trp Glu Arg Glu Arg Arg Asp Ala Ser Glu Glu Thr Ser Thr Ser
     450                 455                 460                
 Val Met Gln Lys Thr Pro Ile Ile Leu Ser Lys Pro Pro Ala Glu Arg
 465                 470                 475                 480
 Ser Lys Gln Pro Pro Pro Pro Thr Ala Pro Ala Ala Pro Pro Ala Pro
                 485                 490                 495    
 Ala Pro Leu Glu Lys Pro Ile Val Leu Met Lys Pro Arg Glu Glu Gly
             500                 505                 510        
 Lys Gly Pro Val Ala Val Thr Gly Ala Ser Thr Pro Glu Gly Thr Ala
         515                 520                 525            
 Pro Pro Pro Pro Ala Ala Pro Ala Pro Pro Lys Gly Glu Lys Glu Gly
     530                 535                 540                
 Gln Arg Pro Thr Gln Pro Val Tyr Gln Ile Gln Asn Arg Gly Met Gly
 545                 550                 555                 560
 Thr Ala Ala Pro Ala Ala Met Asp Pro Val Val Gly Gln Ala Lys Leu
                 565                 570                 575    
 Leu Pro Pro Glu Arg Met Lys His Ser Ile Lys Leu Val Asp Asp Gln
             580                 585                 590        
 Met Asn Trp Cys Asp Ser Ala Ile Glu Tyr Leu Leu Asp Gln Thr Asp
         595                 600                 605            
 Val Leu Val Val Gly Val Leu Gly Leu Gln Gly Thr Gly Lys Ser Met
     610                 615                 620                
 Val Met Ser Leu Leu Ser Ala Asn Thr Pro Glu Glu Asp Gln Arg Thr
 625                 630                 635                 640
 Tyr Val Phe Arg Ala Gln Ser Ala Glu Met Lys Glu Arg Gly Gly Asn
                 645                 650                 655    
 Gln Thr Ser Gly Ile Asp Phe Phe Ile Thr Gln Glu Arg Ile Val Phe
             660                 665                 670        
 Leu Asp Thr Gln Pro Ile Leu Ser Pro Ser Ile Leu Asp His Leu Ile
         675                 680                 685            
 Asn Asn Asp Arg Lys Leu Pro Pro Glu Tyr Asn Leu Pro His Thr Tyr
     690                 695                 700                
 Val Glu Met Gln Ser Leu Gln Ile Ala Ala Phe Leu Phe Thr Val Cys
 705                 710                 715                 720
 His Val Val Ile Val Val Gln Asp Trp Phe Thr Asp Leu Ser Leu Tyr
                 725                 730                 735    
 Arg Leu Trp Asp Leu Gly Cys Lys Cys Lys Ser Asn Ser His Ser Pro
             740                 745                 750        
 Gln Thr Pro Arg Phe Leu Gln Thr Ala Glu Met Val Lys Pro Ser Thr
         755                 760                 765            
 Pro Ser Pro Ser His Glu Ser Ser Ser Ser Ser Gly Ser Asp Glu Gly
     770                 775                 780                
 Thr Glu Tyr Tyr Pro His Leu Val Phe Leu Gln Asn Lys Ala Arg Arg
 785                 790                 795                 800
 Glu Asp Phe Cys Pro Arg Lys Leu Arg Gln Met His Leu Met Ile Asp
                 805                 810                 815    
 Gln Leu Met Ala His Ser His Leu Arg Tyr Lys Gly Thr Leu Ser Met
             820                 825                 830        
 Leu Gln Cys Asn Val Phe Pro Gly Leu Pro Pro Asp Phe Leu Asp Ser
         835                 840                 845            
 Glu Val Asn Leu Phe Leu Val Pro Phe Met Asp Ser Glu Ala Glu Ser
     850                 855                 860                
 Glu Asn Pro Pro Arg Ala Gly Pro Gly Ser Ser Pro Leu Phe Ser Leu
 865                 870                 875                 880
 Leu Pro Gly Tyr Arg Gly His Pro Ser Phe Gln Ser Leu Val Ser Lys
                 885                 890                 895    
 Leu Arg Ser Gln Val Met Ser Met Ala Arg Pro Gln Leu Ser His Thr
             900                 905                 910        
 Ile Leu Thr Glu Lys Asn Trp Phe His Tyr Ala Ala Arg Ile Trp Asp
         915                 920                 925            
 Gly Val Arg Lys Ser Ser Ala Leu Ala Glu Tyr Ser Arg Leu Leu Ala
     930                 935                 940                





      <210> 1143
      <211> 366
      <212> PRT
      <213> Homo sapiens


      <400> 1143
 Met Pro Ala Lys Leu Gln Gly Asn Gly Ile Met Thr Ala Ser Thr Phe
   1               5                  10                  15    
 Arg Pro Gln Ala Asn Ala Leu Asn His Lys Ser Met Ala Asn Leu Asp
              20                  25                  30        
 Lys Tyr Thr Glu Thr Phe Lys Met Gly Ser Asn Ser Thr Ser Thr Ala
          35                  40                  45            
 Glu Ile Tyr Cys Asn Val Thr Asn Val Lys Phe Gln Tyr Ser Leu Tyr
      50                  55                  60                
 Ala Thr Thr Tyr Ile Leu Ile Phe Ile Pro Gly Leu Leu Ala Asn Ser
  65                  70                  75                  80
 Ala Ala Leu Trp Val Leu Cys Arg Phe Ile Ser Lys Lys Asn Lys Ala
                  85                  90                  95    
 Ile Ile Phe Met Ile Asn Leu Ser Val Ala Asp Leu Ala His Val Leu
             100                 105                 110        
 Ser Leu Pro Leu Arg Ile Tyr Tyr Tyr Ile Ser His His Trp Pro Phe
         115                 120                 125            
 Gln Arg Ala Leu Cys Leu Leu Cys Phe Tyr Leu Lys Tyr Leu Asn Met
     130                 135                 140                
 Tyr Ala Ser Ile Cys Phe Leu Thr Cys Ile Ser Leu Gln Arg Cys Phe
 145                 150                 155                 160
 Phe Leu Leu Lys Pro Phe Arg Ala Arg Asp Trp Lys Arg Arg Tyr Asp
                 165                 170                 175    
 Val Gly Ile Ser Ala Ala Ile Trp Ile Val Val Gly Thr Ala Cys Leu
             180                 185                 190        
 Pro Phe Pro Ile Leu Arg Ser Thr Asp Leu Asn Asn Asn Lys Ser Cys
         195                 200                 205            
 Phe Ala Asp Leu Gly Tyr Lys Gln Met Asn Ala Val Ala Leu Val Gly
     210                 215                 220                
 Met Ile Thr Val Ala Glu Leu Ala Gly Phe Val Ile Pro Val Ile Ile
 225                 230                 235                 240
 Ile Ala Trp Cys Thr Trp Lys Thr Thr Ile Ser Leu Arg Gln Pro Pro
                 245                 250                 255    
 Met Ala Phe Gln Gly Ile Ser Glu Arg Gln Lys Ala Leu Arg Met Val
             260                 265                 270        
 Phe Met Cys Ala Ala Val Phe Phe Ile Cys Phe Thr Pro Tyr His Ile
         275                 280                 285            
 Asn Phe Ile Phe Tyr Thr Met Val Lys Glu Thr Ile Ile Ser Ser Cys
     290                 295                 300                
 Pro Val Val Arg Ile Ala Leu Tyr Phe His Pro Phe Cys Leu Cys Leu
 305                 310                 315                 320
 Ala Ser Leu Cys Cys Leu Leu Asp Pro Ile Leu Tyr Tyr Phe Met Ala
                 325                 330                 335    
 Ser Glu Phe Arg Asp Gln Leu Ser Arg His Gly Ser Ser Val Thr Arg
             340                 345                 350        
 Ser Arg Leu Met Ser Lys Glu Ser Gly Ser Ser Met Ile Gly
         355                 360                 365    



      <210> 1144
      <211> 248
      <212> PRT
      <213> Homo sapiens


      <400> 1144
 Met Ala Pro Lys Ala Ala Lys Gly Ala Lys Pro Glu Pro Ala Pro Ala
   1               5                  10                  15    
 Pro Pro Pro Pro Gly Ala Lys Pro Glu Glu Asp Lys Lys Asp Gly Lys
              20                  25                  30        
 Glu Pro Ser Asp Lys Pro Gln Lys Ala Val Gln Asp His Lys Glu Pro
          35                  40                  45            
 Ser Asp Lys Pro Gln Lys Ala Val Gln Pro Lys His Glu Val Gly Thr
      50                  55                  60                
 Arg Arg Gly Cys Arg Arg Tyr Arg Trp Glu Leu Lys Asp Ser Asn Lys
  65                  70                  75                  80
 Glu Phe Trp Leu Leu Gly His Ala Glu Ile Lys Ile Arg Ser Leu Gly
                  85                  90                  95    
 Cys Leu Ile Ala Ala Met Ile Leu Leu Ser Ser Leu Thr Val His Pro
             100                 105                 110        
 Ile Leu Arg Leu Ile Ile Thr Met Glu Ile Ser Phe Phe Ser Phe Phe
         115                 120                 125            
 Ile Leu Leu Tyr Ser Phe Ala Ile His Arg Tyr Ile Pro Phe Ile Leu
     130                 135                 140                
 Trp Pro Ile Ser Asp Leu Phe Asn Asp Leu Ile Ala Cys Ala Phe Leu
 145                 150                 155                 160
 Val Gly Ala Val Val Phe Ala Val Arg Ser Arg Arg Ser Met Asn Leu
                 165                 170                 175    
 His Tyr Leu Leu Ala Val Ile Leu Ile Gly Ala Ala Gly Val Phe Ala
             180                 185                 190        
 Phe Ile Asp Val Cys Leu Gln Arg Asn His Phe Arg Gly Lys Lys Ala
         195                 200                 205            
 Lys Lys His Met Leu Val Pro Pro Pro Gly Lys Glu Lys Gly Pro Gln
     210                 215                 220                
 Gln Gly Lys Gly Pro Glu Pro Ala Lys Pro Pro Glu Pro Gly Lys Pro
 225                 230                 235                 240
 Pro Gly Pro Ala Lys Gly Lys Lys
                 245            



      <210> 1145
      <211> 828
      <212> PRT
      <213> Homo sapiens


      <400> 1145
 Met Leu Leu Asn Ser Phe Ser Phe Ser Ile Met Asp Val Ser His Ile
   1               5                  10                  15    
 Ile Leu Pro Thr Ile Pro Met Ala Ile Ile Tyr Gln Pro Pro Met Phe
              20                  25                  30        
 Ser Gln Leu Leu Lys Ala Leu Gln Thr Asp Val Pro Thr Pro Ala Thr
          35                  40                  45            
 Gln Leu Leu Trp Pro Asn Phe Asn Pro Ile His His Ser Gln Leu Leu
      50                  55                  60                
 His Leu Leu Lys Lys Phe Leu Lys Phe Gln Tyr Leu Ser Tyr Leu Ile
  65                  70                  75                  80
 Gly Ala Lys Leu Thr Arg Glu Ser Glu Lys Ser Lys Glu Phe Lys Ser
                  85                  90                  95    
 Ile Asp Ile Gly Gln Ile Phe Gln Met Lys Thr Ala Ile Lys Lys Lys
             100                 105                 110        
 Arg Gly Ala Ala Lys Ala Met Ser Val Pro Ser Ser Leu Ser Gln Ser
         115                 120                 125            
 Ala Ile Asn Ala Asn Ser His Gly Gly Pro Ala Leu Ser Leu Pro Leu
     130                 135                 140                
 Pro Leu His Ala Ala His Asn Gln Leu Leu Asn Ala Lys Leu Gln Ala
 145                 150                 155                 160
 Thr Ala Val Gly Pro Lys Asp Leu Arg Ser Ala Met Gly Glu Gly Gly
                 165                 170                 175    
 Gly Pro Glu Pro Gly Pro Ala Asn Ala Lys Trp Leu Lys Glu Gly Gln
             180                 185                 190        
 Asn Gln Leu Arg Arg Ala Ala Thr Ala His Arg Asp Gln Asn Arg Asn
         195                 200                 205            
 Val Thr Leu Thr Leu Ala Glu Glu Ala Ser Gln Glu Pro Glu Met Ala
     210                 215                 220                
 Pro Leu Gly Pro Lys Gly Leu Ile His Leu Tyr Ser Glu Leu Glu Leu
 225                 230                 235                 240
 Ser Ala His Asn Ala Ala Asn Arg Gly Leu Arg Gly Pro Gly Leu Ile
                 245                 250                 255    
 Ile Ser Thr Gln Glu Gln Gly Pro Asp Glu Gly Glu Glu Lys Ala Ala
             260                 265                 270        
 Gly Glu Ala Glu Glu Glu Glu Glu Asp Asp Asp Asp Glu Glu Glu Glu
         275                 280                 285            
 Glu Asp Leu Ser Ser Pro Pro Gly Leu Pro Glu Pro Leu Glu Ser Val
     290                 295                 300                
 Glu Ala Pro Pro Arg Pro Gln Ala Leu Thr Asp Gly Pro Arg Glu His
 305                 310                 315                 320
 Ser Lys Ser Ala Ser Leu Leu Phe Gly Met Arg Asn Ser Ala Ala Ser
                 325                 330                 335    
 Asp Glu Asp Ser Ser Trp Ala Thr Leu Ser Gln Gly Ser Pro Ser Tyr
             340                 345                 350        
 Gly Ser Pro Glu Asp Thr Asp Ser Phe Trp Asn Pro Asn Ala Phe Glu
         355                 360                 365            
 Thr Asp Ser Asp Leu Pro Ala Gly Trp Met Arg Val Gln Asp Thr Ser
     370                 375                 380                
 Gly Thr Tyr Tyr Trp His Ile Pro Thr Gly Thr Thr Gln Trp Glu Pro
 385                 390                 395                 400
 Pro Gly Arg Ala Ser Pro Ser Gln Gly Ser Ser Pro Gln Glu Glu Ser
                 405                 410                 415    
 Gln Leu Thr Trp Thr Gly Phe Ala His Gly Glu Gly Phe Glu Asp Gly
             420                 425                 430        
 Glu Phe Trp Lys Asp Glu Pro Ser Asp Glu Ala Pro Met Glu Leu Gly
         435                 440                 445            
 Leu Lys Glu Pro Glu Glu Gly Thr Leu Thr Phe Pro Ala Gln Ser Leu
     450                 455                 460                
 Ser Pro Glu Pro Leu Pro Gln Glu Glu Glu Lys Leu Pro Pro Arg Asn
 465                 470                 475                 480
 Thr Asn Pro Gly Ile Lys Cys Phe Ala Val Arg Ser Leu Gly Trp Val
                 485                 490                 495    
 Glu Met Thr Glu Glu Glu Leu Ala Pro Gly Arg Ser Ser Val Ala Val
             500                 505                 510        
 Asn Asn Cys Ile Arg Gln Leu Ser Tyr His Lys Asn Asn Leu His Asp
         515                 520                 525            
 Pro Met Ser Gly Gly Trp Gly Glu Gly Lys Asp Leu Leu Leu Gln Leu
     530                 535                 540                
 Glu Asp Glu Thr Leu Lys Leu Val Glu Pro Gln Ser Gln Ala Leu Leu
 545                 550                 555                 560
 His Ala Gln Pro Ile Ile Ser Ile Arg Val Trp Gly Val Gly Arg Asp
                 565                 570                 575    
 Ser Gly Arg Glu Arg Asp Phe Ala Tyr Val Ala Arg Asp Lys Leu Thr
             580                 585                 590        
 Gln Met Leu Lys Cys His Val Phe Arg Cys Glu Ala Pro Ala Lys Asn
         595                 600                 605            
 Ile Ala Thr Ser Leu His Glu Ile Cys Ser Lys Ile Met Ala Glu Arg
     610                 615                 620                
 Arg Asn Ala Arg Cys Leu Val Asn Gly Leu Ser Leu Asp His Ser Lys
 625                 630                 635                 640
 Leu Val Asp Val Pro Phe Gln Val Glu Phe Pro Ala Pro Lys Asn Glu
                 645                 650                 655    
 Leu Val Gln Lys Phe Gln Val Tyr Tyr Leu Gly Asn Val Pro Val Ala
             660                 665                 670        
 Lys Pro Val Gly Val Asp Val Ile Asn Gly Ala Leu Glu Ser Val Leu
         675                 680                 685            
 Ser Ser Ser Ser Arg Glu Gln Trp Thr Pro Ser His Val Ser Val Ala
     690                 695                 700                
 Pro Ala Thr Leu Thr Ile Leu His Gln Gln Thr Glu Ala Val Leu Gly
 705                 710                 715                 720
 Glu Cys Arg Val Arg Phe Leu Ser Phe Leu Ala Val Gly Arg Asp Val
                 725                 730                 735    
 His Thr Phe Ala Phe Ile Met Ala Ala Gly Pro Ala Ser Phe Cys Cys
             740                 745                 750        
 His Met Phe Trp Cys Glu Pro Asn Ala Ala Ser Leu Ser Glu Ala Val
         755                 760                 765            
 Gln Ala Ala Cys Met Leu Arg Tyr Gln Lys Cys Leu Asp Ala Arg Ser
     770                 775                 780                
 Gln Ala Ser Thr Ser Cys Leu Pro Ala Pro Pro Ala Glu Ser Val Ala
 785                 790                 795                 800
 Arg Arg Val Gly Trp Thr Val Arg Arg Gly Val Gln Ser Leu Trp Gly
                 805                 810                 815    
 Ser Leu Lys Pro Lys Arg Leu Gly Ala His Thr Pro
             820                 825            



      <210> 1146
      <211> 170
      <212> PRT
      <213> Homo sapiens


      <400> 1146
 Met Asp Val Asn Ile Ala Pro Leu Arg Ala Trp Asp Asp Phe Phe Pro
   1               5                  10                  15    
 Gly Ser Asp Arg Phe Ala Arg Pro Asp Phe Arg Asp Ile Ser Lys Trp
              20                  25                  30        
 Asn Asn Arg Val Val Ser Asn Leu Leu Tyr Tyr Gln Thr Asn Tyr Leu
          35                  40                  45            
 Val Val Ala Ala Met Met Ile Ser Ile Val Gly Phe Leu Ser Pro Phe
      50                  55                  60                
 Asn Met Ile Leu Gly Gly Ile Val Val Val Leu Val Phe Thr Gly Phe
  65                  70                  75                  80
 Val Trp Ala Ala His Asn Lys Asp Val Leu Arg Arg Met Lys Lys Arg
                  85                  90                  95    
 Tyr Pro Thr Thr Phe Val Met Val Val Met Leu Ala Ser Tyr Phe Leu
             100                 105                 110        
 Ile Ser Met Phe Gly Gly Val Met Val Phe Val Phe Gly Ile Thr Phe
         115                 120                 125            
 Pro Leu Leu Leu Met Phe Ile His Ala Ser Leu Arg Leu Arg Asn Leu
     130                 135                 140                
 Lys Asn Lys Leu Glu Asn Leu Glu Gln Gln Glu Glu Gly Ile Asn Arg
 145                 150                 155                 160
 Leu Thr Asp Tyr Ile Ser Lys Val Lys Glu
                 165                 170



      <210> 1147
      <211> 185
      <212> PRT
      <213> Homo sapiens


      <400> 1147
 Met Ala Lys Glu Glu Pro Gln Ser Ile Ser Arg Asp Leu Gln Glu Leu
   1               5                  10                  15    
 Gln Lys Lys Leu Ser Leu Leu Ile Asp Ser Phe Gln Asn Asn Ser Lys
              20                  25                  30        
 Leu Pro Gln His Ser Arg Ile Ser Leu Asp Ser Asp Asp Gly Val Ser
          35                  40                  45            
 Arg Leu Gly Ser Ala Gly Ser Lys Val Val Ala Phe Met Lys Ser Pro
      50                  55                  60                
 Val Gly Gln Tyr Leu Asp Ser His Pro Phe Leu Ala Phe Thr Leu Leu
  65                  70                  75                  80
 Val Phe Ile Val Met Ser Ala Val Pro Val Gly Phe Phe Leu Leu Ile
                  85                  90                  95    
 Val Val Leu Thr Thr Leu Ala Ala Leu Leu Gly Val Ile Ile Leu Glu
             100                 105                 110        
 Gly Leu Val Ile Ser Val Gly Gly Phe Ser Leu Leu Cys Ile Leu Cys
         115                 120                 125            
 Gly Leu Gly Phe Val Ser Leu Ala Met Ser Gly Met Met Ile Ala Ser
     130                 135                 140                
 Tyr Val Val Val Ser Ser Leu Ile Ser Cys Trp Phe Ser Pro Arg Pro
 145                 150                 155                 160
 Leu Thr Gln Gln Asn Thr Ser Cys Asp Phe Leu Pro Ala Met Lys Ser
                 165                 170                 175    
 Ala Asp Phe Glu Gly Leu Tyr Gln Glu
             180                 185



      <210> 1148
      <211> 607
      <212> PRT
      <213> Homo sapiens


      <400> 1148
 Met Gly Ser Ala Phe Val Ile Leu Ser Asp Leu Glu Leu Asn Arg Thr
   1               5                  10                  15    
 Thr Glu His Ile Leu Lys Leu Glu Asp Pro Asn Ser Leu Glu Asp Asp
              20                  25                  30        
 Met Gly Val Ile Val Leu Asn Leu Asn Leu Val Val Lys Gln Gly Asp
          35                  40                  45            
 Phe Lys Arg His Arg Trp Ser Asn Arg Lys Arg Leu Ser Ala Ser Lys
      50                  55                  60                
 Ser Ser Leu Ile Arg Asn Leu Arg Leu Ser Glu Ser Leu Lys Lys Asn
  65                  70                  75                  80
 Gln Leu Trp Asn Gly Ile Ile Ser Ile Thr Leu Leu Glu Gly Lys Asn
                  85                  90                  95    
 Val Ser Gly Gly Ser Met Thr Glu Met Phe Val Gln Leu Lys Leu Gly
             100                 105                 110        
 Asp Gln Arg Tyr Lys Ser Lys Thr Leu Cys Lys Ser Ala Asn Pro Gln
         115                 120                 125            
 Trp Gln Glu Gln Phe Asp Phe His Tyr Phe Ser Asp Arg Met Gly Ile
     130                 135                 140                
 Leu Asp Ile Glu Val Trp Gly Lys Asp Asn Lys Lys His Glu Glu Arg
 145                 150                 155                 160
 Leu Gly Thr Cys Lys Val Asp Ile Ser Ala Leu Pro Leu Lys Gln Ala
                 165                 170                 175    
 Asn Cys Leu Glu Leu Pro Leu Asp Ser Cys Leu Gly Ala Leu Leu Met
             180                 185                 190        
 Leu Val Thr Leu Thr Pro Cys Ala Gly Val Ser Val Ser Asp Leu Cys
         195                 200                 205            
 Val Cys Pro Leu Ala Asp Leu Ser Glu Arg Lys Gln Ile Thr Gln Arg
     210                 215                 220                
 Tyr Cys Leu Gln Asn Ser Leu Lys Asp Val Lys Asp Val Gly Ile Leu
 225                 230                 235                 240
 Gln Val Lys Val Leu Lys Ala Ala Asp Leu Leu Ala Ala Asp Phe Ser
                 245                 250                 255    
 Gly Lys Ser Asp Pro Phe Cys Leu Leu Glu Leu Gly Asn Asp Arg Leu
             260                 265                 270        
 Gln Thr His Thr Val Tyr Lys Asn Leu Asn Pro Glu Trp Asn Lys Val
         275                 280                 285            
 Phe Thr Phe Pro Ile Lys Asp Ile His Asp Val Leu Glu Val Thr Val
     290                 295                 300                
 Phe Asp Glu Asp Gly Asp Lys Pro Pro Asp Phe Leu Gly Lys Val Ala
 305                 310                 315                 320
 Ile Pro Leu Leu Ser Ile Arg Asp Gly Gln Pro Asn Cys Tyr Val Leu
                 325                 330                 335    
 Lys Asn Lys Asp Leu Glu Gln Ala Phe Lys Gly Val Ile Tyr Leu Glu
             340                 345                 350        
 Met Asp Leu Ile Tyr Asn Pro Val Lys Ala Ser Ile Arg Thr Phe Thr
         355                 360                 365            
 Pro Arg Glu Lys Arg Phe Val Glu Asp Ser Arg Lys Leu Ser Lys Lys
     370                 375                 380                
 Ile Leu Ser Arg Asp Val Asp Arg Val Lys Arg Ile Thr Met Ala Ile
 385                 390                 395                 400
 Trp Asn Thr Met Gln Phe Leu Lys Ser Cys Phe Gln Trp Glu Ser Thr
                 405                 410                 415    
 Leu Arg Ser Thr Ile Ala Phe Ala Val Phe Leu Ile Thr Val Trp Asn
             420                 425                 430        
 Phe Glu Leu Tyr Met Ile Pro Leu Ala Leu Leu Leu Ile Phe Val Tyr
         435                 440                 445            
 Asn Phe Ile Arg Pro Val Lys Gly Lys Val Ser Ser Ile Gln Asp Ser
     450                 455                 460                
 Gln Glu Ser Thr Asp Ile Asp Asp Glu Glu Asp Glu Asp Asp Lys Glu
 465                 470                 475                 480
 Ser Glu Lys Lys Gly Leu Ile Glu Arg Ile Tyr Met Val Gln Asp Ile
                 485                 490                 495    
 Val Ser Thr Val Gln Asn Val Leu Glu Glu Ile Ala Ser Phe Gly Glu
             500                 505                 510        
 Arg Ile Lys Asn Thr Phe Asn Trp Thr Val Pro Phe Leu Ser Ser Leu
         515                 520                 525            
 Ala Cys Leu Ile Leu Ala Ala Ala Thr Ile Ile Leu Tyr Phe Ile Pro
     530                 535                 540                
 Leu Arg Tyr Ile Ile Leu Ile Trp Gly Ile Asn Lys Phe Thr Lys Lys
 545                 550                 555                 560
 Leu Arg Asn Pro Tyr Ser Ile Asp Asn Asn Glu Leu Leu Asp Phe Leu
                 565                 570                 575    
 Ser Arg Val Pro Ser Asp Val Gln Lys Val Gln Tyr Ala Glu Leu Lys
             580                 585                 590        
 Leu Cys Ser Ser His Ser Pro Leu Arg Lys Lys Arg Ser Ala Leu
         595                 600                 605        



      <210> 1149
      <211> 484
      <212> PRT
      <213> Homo sapiens


      <400> 1149
 Met Pro Gly Ser Cys Arg Arg Gly Ala Gly Ala Ala Val Ala Ala Thr
   1               5                  10                  15    
 Ala Pro Gly Ile Pro Arg Arg Ala Ala Ala Ala Gly Gly Gly Ser Ala
              20                  25                  30        
 Gly Ser Trp Gly Gly Gly Gly Arg Gly Val Ala Gly Gly Gly Gly Arg
          35                  40                  45            
 Gly Pro Gly Gly Gly Arg Val Thr Trp Leu Leu Gly Glu Pro Val Leu
      50                  55                  60                
 Trp Leu Gly Cys Arg Ala Asp Glu Leu Leu Ser Trp Lys Arg Pro Leu
  65                  70                  75                  80
 Arg Ser Leu Leu Gly Phe Val Ala Ala Asn Leu Leu Phe Trp Phe Leu
                  85                  90                  95    
 Ala Leu Thr Pro Trp Arg Val Tyr His Leu Ile Ser Val Met Ile Leu
             100                 105                 110        
 Gly Arg Val Ile Met Gln Ile Ile Lys Asp Met Val Leu Ser Arg Thr
         115                 120                 125            
 Arg Gly Ala Gln Leu Trp Arg Ser Leu Ser Glu Ser Trp Glu Val Ile
     130                 135                 140                
 Asn Ser Lys Pro Asp Glu Arg Pro Arg Leu Ser His Cys Ile Ala Glu
 145                 150                 155                 160
 Ser Trp Met Asn Phe Ser Ile Phe Leu Gln Glu Met Ser Leu Phe Lys
                 165                 170                 175    
 Gln Gln Ser Pro Gly Lys Phe Cys Leu Leu Val Cys Ser Val Cys Thr
             180                 185                 190        
 Phe Phe Thr Ile Leu Gly Ser Tyr Ile Pro Gly Val Ile Leu Ser Tyr
         195                 200                 205            
 Leu Leu Leu Leu Cys Ala Phe Leu Cys Pro Leu Phe Lys Cys Asn Asp
     210                 215                 220                
 Ile Gly Gln Lys Ile Tyr Ser Lys Ile Lys Ser Val Leu Leu Lys Leu
 225                 230                 235                 240
 Asp Phe Gly Ile Gly Glu Tyr Ile Asn Gln Lys Lys Arg Glu Arg Ser
                 245                 250                 255    
 Glu Ala Asp Lys Glu Lys Ser His Lys Asp Asp Ser Glu Leu Asp Phe
             260                 265                 270        
 Ser Ala Leu Cys Pro Lys Ile Ser Leu Thr Val Ala Ala Lys Glu Leu
         275                 280                 285            
 Ser Val Ser Asp Thr Asp Val Ser Glu Val Ser Trp Thr Asp Asn Gly
     290                 295                 300                
 Thr Phe Asn Leu Ser Glu Gly Tyr Thr Pro Gln Thr Asp Thr Ser Asp
 305                 310                 315                 320
 Asp Leu Asp Arg Pro Ser Glu Glu Val Phe Ser Arg Asp Leu Ser Asp
                 325                 330                 335    
 Phe Pro Ser Leu Glu Asn Gly Met Gly Thr Asn Asp Glu Asp Glu Leu
             340                 345                 350        
 Ser Leu Gly Leu Pro Thr Glu Leu Lys Arg Lys Lys Glu Gln Leu Asp
         355                 360                 365            
 Ser Gly His Arg Pro Ser Lys Glu Thr Gln Ser Ala Ala Gly Leu Thr
     370                 375                 380                
 Leu Pro Leu Asn Ser Asp Gln Thr Phe His Leu Met Ser Asn Leu Ala
 385                 390                 395                 400
 Gly Asp Val Ile Thr Ala Ala Val Thr Ala Ala Ile Lys Asp Gln Leu
                 405                 410                 415    
 Glu Gly Val Gln Gln Ala Leu Ser Gln Ala Ala Pro Ile Pro Glu Glu
             420                 425                 430        
 Asp Thr Asp Thr Glu Glu Gly Asp Asp Phe Glu Leu Leu Asp Gln Ser
         435                 440                 445            
 Glu Leu Asp Gln Ile Glu Ser Glu Leu Gly Leu Thr Gln Asp Gln Glu
     450                 455                 460                
 Ala Glu Ala Gln Gln Asn Lys Lys Ser Ser Gly Phe Leu Ser Asn Leu
 465                 470                 475                 480
 Leu Gly Gly His
                



      <210> 1150
      <211> 484
      <212> PRT
      <213> Homo sapiens


      <400> 1150
 Met Pro Gly Ser Cys Arg Arg Gly Ala Gly Ala Ala Val Ala Ala Thr
   1               5                  10                  15    
 Ala Pro Gly Ile Pro Arg Arg Ala Ala Ala Ala Gly Gly Gly Ser Ala
              20                  25                  30        
 Gly Ser Trp Gly Gly Gly Gly Arg Gly Val Ala Gly Gly Gly Gly Arg
          35                  40                  45            
 Gly Pro Gly Gly Gly Arg Gly Asn Leu Ala Ala Arg Gly Ala Gly Ala
      50                  55                  60                
 Val Ala Gly Leu Pro Arg Arg Arg Ala Ala Glu Leu Glu Glu Ala Ala
  65                  70                  75                  80
 Ala Glu Pro Ala Arg Leu Arg Arg Cys Gln Pro Ala Val Leu Val Leu
                  85                  90                  95    
 Ala Leu Thr Pro Trp Arg Val Tyr His Leu Ile Ser Val Met Ile Leu
             100                 105                 110        
 Gly Arg Val Ile Met Gln Ile Ile Lys Asp Met Val Leu Ser Arg Thr
         115                 120                 125            
 Arg Gly Ala Gln Leu Trp Arg Ser Leu Ser Glu Ser Trp Glu Val Ile
     130                 135                 140                
 Asn Ser Lys Pro Asp Glu Arg Pro Arg Leu Ser His Cys Ile Ala Glu
 145                 150                 155                 160
 Ser Trp Met Asn Phe Ser Ile Phe Leu Gln Glu Met Ser Leu Phe Lys
                 165                 170                 175    
 Gln Gln Ser Pro Gly Lys Phe Cys Leu Leu Val Cys Ser Val Cys Thr
             180                 185                 190        
 Phe Phe Thr Ile Leu Gly Ser Tyr Ile Pro Gly Val Ile Leu Ser Tyr
         195                 200                 205            
 Leu Leu Leu Leu Cys Ala Phe Leu Cys Pro Leu Phe Lys Cys Asn Asp
     210                 215                 220                
 Ile Gly Gln Lys Ile Tyr Ser Lys Ile Lys Ser Val Leu Leu Lys Leu
 225                 230                 235                 240
 Asp Phe Gly Ile Gly Glu Tyr Ile Asn Gln Lys Lys Arg Glu Arg Ser
                 245                 250                 255    
 Glu Ala Asp Lys Glu Lys Ser His Lys Asp Asp Ser Glu Leu Asp Phe
             260                 265                 270        
 Ser Ala Leu Cys Pro Lys Ile Ser Leu Thr Val Ala Ala Lys Glu Leu
         275                 280                 285            
 Ser Val Ser Asp Thr Asp Val Ser Glu Val Ser Trp Thr Asp Asn Gly
     290                 295                 300                
 Thr Phe Asn Leu Ser Glu Gly Tyr Thr Pro Gln Thr Asp Thr Ser Asp
 305                 310                 315                 320
 Asp Leu Asp Arg Pro Ser Glu Glu Val Phe Ser Arg Asp Leu Ser Asp
                 325                 330                 335    
 Phe Pro Ser Leu Glu Asn Gly Met Gly Thr Asn Asp Glu Asp Glu Leu
             340                 345                 350        
 Ser Leu Gly Leu Pro Thr Glu Leu Lys Arg Lys Lys Glu Gln Leu Asp
         355                 360                 365            
 Ser Gly His Arg Pro Ser Lys Glu Thr Gln Ser Ala Ala Gly Leu Thr
     370                 375                 380                
 Leu Pro Leu Asn Ser Asp Gln Thr Phe His Leu Met Ser Asn Leu Ala
 385                 390                 395                 400
 Gly Asp Val Ile Thr Ala Ala Val Thr Ala Ala Ile Lys Asp Gln Leu
                 405                 410                 415    
 Glu Gly Val Gln Gln Ala Leu Ser Gln Ala Ala Pro Ile Pro Glu Glu
             420                 425                 430        
 Asp Thr Asp Thr Glu Glu Gly Asp Asp Phe Glu Leu Leu Asp Gln Ser
         435                 440                 445            
 Glu Leu Asp Gln Ile Glu Ser Glu Leu Gly Leu Thr Gln Asp Gln Glu
     450                 455                 460                
 Ala Glu Ala Gln Gln Asn Lys Lys Ser Ser Gly Phe Leu Ser Asn Leu
 465                 470                 475                 480
 Leu Gly Gly His
                



      <210> 1151
      <211> 124
      <212> PRT
      <213> Homo sapiens


      <400> 1151
 Met His Lys Glu Glu His Gly Val Ala Val Leu Gly Ala Pro Pro Ser
   1               5                  10                  15    
 Thr Ile Leu Pro Arg Ser Thr Val Ile Asn Ile His Ser Glu Thr Ser
              20                  25                  30        
 Val Pro Asp His Val Asp Trp Ser Leu Phe Asn Thr Leu Phe Leu Asn
          35                  40                  45            
 Cys Cys Cys Leu Gly Phe Ile Ala Phe Ala Tyr Ser Val Lys Ser Arg
      50                  55                  60                
 Asp Arg Lys Met Val Gly Asp Glu Thr Gly Ala Gln Ala Tyr Ala Tyr
  65                  70                  75                  80
 Thr Asp Lys Cys Leu Asn Ile Trp Ala Leu Asn Leu Gly Ile Leu Met
                  85                  90                  95    
 Thr Ile Gly Phe Ile Leu Leu Leu Val Phe Gly Ser Val Thr Asp Tyr
             100                 105                 110        
 His Ile Met Leu Gln Ile Ile Gln Glu Leu Ser Tyr
         115                 120                



      <210> 1152
      <211> 436
      <212> PRT
      <213> Homo sapiens


      <400> 1152
 Met Asp Ser Gly Thr Val Glu Arg Glu Gly Gly Gly Arg Lys Lys Thr
   1               5                  10                  15    
 Glu Arg Ala Ile Pro Ser Gly Ala Thr Lys Thr Ile Ser Pro Pro Val
              20                  25                  30        
 Thr Thr Ser Gly Leu Gly His Val Pro Ala Thr Ser Pro Cys Gln Ser
          35                  40                  45            
 His Ala Thr Gly Cys Thr Glu Ala Ala Leu Leu Lys Glu Leu Pro Thr
      50                  55                  60                
 His Leu His Tyr Leu Asp Gly Glu Met Glu Arg His Ser Lys His Leu
  65                  70                  75                  80
 Cys Ser Ser Leu Gly Lys Val Gln Asp Ala Phe Phe Ser Leu Ala Met
                  85                  90                  95    
 Ala Leu Pro Leu Leu Leu Ser Pro Ser Cys Phe Ala Ser Ser Gln Ser
             100                 105                 110        
 Leu Ser Ser Arg Met Asn Ser Glu Asn Leu Thr Arg Ala Ala Val Ala
         115                 120                 125            
 Pro Ala Glu Phe Val Leu Leu Gly Ile Thr Asn Arg Trp Asp Leu Arg
     130                 135                 140                
 Val Ala Leu Phe Leu Thr Cys Leu Pro Val Tyr Leu Val Ser Leu Leu
 145                 150                 155                 160
 Gly Asn Met Gly Met Ala Leu Leu Ile Arg Met Asp Ala Arg Leu His
                 165                 170                 175    
 Thr Pro Met Tyr Phe Phe Leu Ala Asn Leu Ser Leu Leu Asp Ala Cys
             180                 185                 190        
 Tyr Ser Ser Ala Ile Gly Pro Lys Met Leu Val Asp Leu Leu Leu Pro
         195                 200                 205            
 Arg Ala Thr Ile Pro Tyr Thr Ala Cys Ala Leu Gln Met Phe Val Phe
     210                 215                 220                
 Ala Gly Leu Ala Asp Thr Glu Cys Cys Leu Leu Ala Ala Met Ala Tyr
 225                 230                 235                 240
 Asp Arg Tyr Val Ala Ile Arg Asn Pro Leu Leu Tyr Thr Thr Ala Met
                 245                 250                 255    
 Ser Gln Arg Leu Cys Leu Ala Leu Leu Gly Ala Ser Gly Leu Gly Gly
             260                 265                 270        
 Ala Val Ser Ala Phe Val His Thr Thr Leu Thr Phe Arg Leu Ser Phe
         275                 280                 285            
 Cys Arg Ser Arg Lys Ile Asn Ser Phe Phe Cys Asp Ile Pro Pro Leu
     290                 295                 300                
 Leu Ala Ile Ser Cys Ser Asp Thr Ser Leu Asn Glu Leu Leu Leu Phe
 305                 310                 315                 320
 Ala Ile Cys Gly Phe Ile Gln Thr Ala Thr Val Leu Ala Ile Thr Val
                 325                 330                 335    
 Ser Tyr Gly Phe Ile Ala Gly Ala Val Ile His Met Arg Ser Val Glu
             340                 345                 350        
 Gly Ser Arg Arg Ala Ala Ser Thr Gly Gly Ser His Leu Thr Ala Val
         355                 360                 365            
 Ala Met Met Tyr Gly Thr Leu Ile Phe Met Tyr Leu Arg Pro Ser Ser
     370                 375                 380                
 Ser Tyr Ala Leu Asp Thr Asp Lys Met Ala Ser Val Phe Tyr Thr Leu
 385                 390                 395                 400
 Val Ile Pro Ser Leu Asn Pro Leu Ile Tyr Ser Leu Arg Asn Lys Glu
                 405                 410                 415    
 Val Lys Glu Ala Leu Arg Gln Thr Trp Ser Arg Phe His Cys Pro Gly
             420                 425                 430        
 Gln Gly Ser Gln
         435    



      <210> 1153
      <211> 1090
      <212> PRT
      <213> Homo sapiens


      <400> 1153
 Met Met Lys Phe Arg Phe Arg Arg Gln Gly Ala Asp Pro Gln Arg Glu
   1               5                  10                  15    
 Lys Leu Lys Gln Glu Leu Phe Ala Phe Asn Lys Thr Val Glu His Gly
              20                  25                  30        
 Phe Pro Asn Gln Pro Ser Ala Leu Ala Phe Asp Pro Glu Leu Arg Ile
          35                  40                  45            
 Met Ala Ile Gly Thr Arg Ser Gly Ala Val Lys Met Tyr Pro Leu Gln
      50                  55                  60                
 Asp Ser Tyr Gly Ala Pro Gly Val Glu Phe Thr Gly Leu His Arg Asp
  65                  70                  75                  80
 Ala Ala Thr Val Thr Gln Met His Phe Leu Thr Gly Gln Gly Arg Leu
                  85                  90                  95    
 Leu Ser Leu Leu Asp Asp Ser Ser Leu His Leu Trp Glu Ile Val His
             100                 105                 110        
 His Asn Gly Cys Ala His Leu Glu Glu Ala Leu Ser Phe Gln Leu Pro
         115                 120                 125            
 Ser Arg Pro Gly Phe Asp Gly Ala Ser Ala Pro Leu Ser Leu Thr Arg
     130                 135                 140                
 Val Thr Val Val Leu Leu Val Ala Ala Gly Asp Ile Ala Ala Leu Gly
 145                 150                 155                 160
 Thr Glu Gly Ser Ser Val Phe Phe Leu Asp Val Thr Thr Leu Thr Leu
                 165                 170                 175    
 Leu Glu Gly Gln Thr Leu Ala Pro Gly Glu Val Leu Arg Ser Val Pro
             180                 185                 190        
 Asp Asp Tyr Arg Cys Gly Lys Ala Leu Gly Pro Val Glu Ser Leu Gln
         195                 200                 205            
 Gly His Leu Arg Asp Pro Thr Lys Ile Leu Ile Gly Tyr Ser Arg Gly
     210                 215                 220                
 Leu Leu Val Ile Trp Asn Gln Ala Ser Gln Cys Val Asp His Ile Phe
 225                 230                 235                 240
 Leu Gly Asn Gln Gln Leu Glu Ser Leu Cys Trp Gly Arg Asp Ser Ser
                 245                 250                 255    
 Thr Val Val Ser Ser His Ser Asp Gly Ser Tyr Ala Val Trp Ser Val
             260                 265                 270        
 Asp Ala Gly Ser Phe Pro Thr Leu Gln Pro Thr Val Ala Thr Thr Pro
         275                 280                 285            
 Tyr Gly Pro Phe Pro Cys Lys Ala Ile Asn Lys Ile Leu Trp Arg Asn
     290                 295                 300                
 Cys Glu Ser Gly Gly His Phe Ile Ile Phe Ser Gly Gly Met Pro Arg
 305                 310                 315                 320
 Ala Ser Tyr Gly Asp Arg His Cys Val Ser Val Leu Arg Ala Glu Thr
                 325                 330                 335    
 Leu Val Thr Leu Asp Phe Thr Ser Arg Ile Ile Asp Phe Phe Thr Val
             340                 345                 350        
 His Ser Thr Arg Pro Glu Asp Glu Phe Asp Asp Pro Gln Ala Leu Ala
         355                 360                 365            
 Val Leu Leu Glu Glu Glu Leu Val Val Leu Asp Leu Gln Thr Pro Gly
     370                 375                 380                
 Trp Pro Ala Val Pro Ala Pro Tyr Leu Ala Pro Leu His Ser Ser Ala
 385                 390                 395                 400
 Ile Thr Cys Ser Ala His Val Ala Ser Val Pro Ala Lys Leu Trp Ala
                 405                 410                 415    
 Arg Ile Val Ser Ala Gly Glu Gln Gln Ser Pro Gln Pro Val Ser Ser
             420                 425                 430        
 Ala Leu Ser Trp Pro Ile Thr Gly Gly Arg Asn Leu Ala Gln Glu Pro
         435                 440                 445            
 Ser Gln Arg Gly Leu Leu Leu Thr Gly His Glu Asp Gly Thr Val Arg
     450                 455                 460                
 Phe Trp Asp Ala Ser Gly Val Ala Leu Arg Pro Leu Tyr Lys Leu Ser
 465                 470                 475                 480
 Thr Ala Gly Leu Phe Gln Thr Asp Cys Glu His Ala Asp Ser Leu Ala
                 485                 490                 495    
 Gln Ala Ala Glu Asp Asp Trp Pro Pro Phe Arg Lys Val Gly Cys Phe
             500                 505                 510        
 Asp Pro Tyr Ser Asp Asp Pro Arg Leu Gly Val Gln Lys Val Ala Leu
         515                 520                 525            
 Cys Lys Tyr Thr Ala Gln Met Val Val Ala Gly Thr Ala Gly Gln Val
     530                 535                 540                
 Leu Val Leu Glu Leu Ser Asp Val Pro Val Glu Gln Ala Val Ser Val
 545                 550                 555                 560
 Ala Ile Ile Asp Leu Leu Gln Asp Arg Glu Gly Phe Thr Trp Lys Gly
                 565                 570                 575    
 His Glu Arg Leu Ser Pro Arg Thr Gly Pro Leu Pro Trp Pro Ala Gly
             580                 585                 590        
 Phe Gln Pro Arg Val Leu Val Gln Cys Leu Pro Pro Ala Ala Val Thr
         595                 600                 605            
 Ala Val Thr Leu His Thr Glu Trp Ser Leu Val Ala Phe Gly Thr Ser
     610                 615                 620                
 His Gly Phe Gly Leu Phe Asp Tyr Gln Arg Lys Ser Pro Val Leu Ala
 625                 630                 635                 640
 Arg Cys Thr Leu His Pro Asn Asp Ser Leu Ala Met Glu Gly Pro Leu
                 645                 650                 655    
 Ser Arg Val Lys Ser Leu Lys Lys Ser Leu Arg Gln Ser Phe Arg Arg
             660                 665                 670        
 Ile Arg Lys Ser Arg Val Ser Gly Lys Lys Arg Ala Ala Asn Ala Ser
         675                 680                 685            
 Ser Lys Leu Gln Glu Ala Asn Ala Gln Leu Ala Glu Gln Ala Cys Pro
     690                 695                 700                
 His Asp Val Glu Met Thr Pro Val Gln Arg Arg Ile Glu Pro Arg Ser
 705                 710                 715                 720
 Ala Asp Asp Ser Leu Ser Gly Val Val Arg Cys Leu Tyr Phe Ala Asp
                 725                 730                 735    
 Thr Phe Leu Arg Asp Gly Ala His His Gly Pro Thr Met Trp Ala Gly
             740                 745                 750        
 Thr Asn Ser Gly Ser Val Phe Ala Tyr Ala Leu Glu Val Pro Ala Ala
         755                 760                 765            
 Ala Val Gly Gly Glu Lys Arg Pro Glu Gln Ala Val Glu Ala Val Leu
     770                 775                 780                
 Gly Lys Glu Val Gln Leu Met His Arg Ala Pro Val Val Ala Ile Ala
 785                 790                 795                 800
 Val Leu Asp Gly Arg Gly Arg Pro Leu Pro Glu Pro Tyr Glu Ala Ser
                 805                 810                 815    
 Arg Asp Leu Ala Gln Ala Pro Asp Met Gln Gly Gly His Ala Val Leu
             820                 825                 830        
 Ile Ala Ser Glu Glu Gln Phe Lys Val Phe Thr Leu Pro Lys Val Ser
         835                 840                 845            
 Ala Lys Thr Lys Phe Lys Leu Thr Ala His Glu Gly Cys Arg Val Arg
     850                 855                 860                
 Lys Val Ala Leu Ala Thr Phe Ala Ser Val Ala Cys Glu Asp Tyr Ala
 865                 870                 875                 880
 Glu Thr Cys Leu Ala Cys Leu Thr Asn Leu Gly Asp Val His Val Phe
                 885                 890                 895    
 Ser Val Pro Gly Leu Arg Pro Gln Val His Tyr Ser Cys Ile Arg Lys
             900                 905                 910        
 Glu Asp Ile Ser Gly Ile Ala Ser Cys Val Phe Thr Arg His Gly Gln
         915                 920                 925            
 Gly Phe Tyr Leu Ile Ser Pro Ser Glu Phe Glu Arg Phe Ser Leu Ser
     930                 935                 940                
 Ala Arg Asn Ile Thr Glu Pro Leu Cys Ser Leu Asp Ile Asn Trp Pro
 945                 950                 955                 960
 Arg Asp Ala Thr Gln Ala Ser Tyr Arg Ile Arg Glu Ser Pro Lys Leu
                 965                 970                 975    
 Ser Gln Ala Asn Gly Thr Pro Ser Ile Leu Leu Ala Pro Gln Ser Leu
             980                 985                 990        
 Asp Gly Ser Pro Asp Pro Ala His Ser Met Gly Pro Gly Pro Gln Val
         995                1000                1005            
 Gln Arg Val Leu Arg Val Leu Val Gly Ala Asp Asp Leu Leu Pro Val
    1010                1015                1020                
 Asp Thr Pro Glu Pro Pro Glu Ala Ala Leu Ser Pro Met Ser Ile Asp
1025                1030                1035                1040
 Ser Ala Thr Ser Ala Asp Thr Thr Leu Asp Thr Thr Gly Asp Val Thr
                1045                1050                1055    
 Val Glu Asp Val Lys Asp Phe Leu Gly Ser Ser Glu Glu Ser Glu Lys
            1060                1065                1070        
 Asn Leu Arg Asn Leu Ala Glu Asp Glu Ala His Ala Cys Ala Ile Leu
        1075                1080                1085            
 Ile Lys
    1090



      <210> 1154
      <211> 227
      <212> PRT
      <213> Homo sapiens


      <400> 1154
 Met Val Leu Leu Ser Ile Leu Gln Thr Val Lys Asp Gln Leu Ser Ser
   1               5                  10                  15    
 Tyr Gly Tyr Trp Gln Asp Ser Val Ser His Gly Ala Leu Asp Lys Gly
              20                  25                  30        
 Leu Ser Ser Ser Leu Thr Val Ala His Ser Gln Phe Leu Glu Met Cys
          35                  40                  45            
 Leu Phe Ser Val Ala Val Phe Phe Ile Glu Ala Cys Lys Pro Gln Gly
      50                  55                  60                
 Pro Arg Glu Ser Gln Gln Asp Gly Ser His Ala Ser Leu Gln Ser Ile
  65                  70                  75                  80
 Thr Pro Val Ala Phe Thr Ala Ser Gly Leu Val Gly Glu Ala Ser Tyr
                  85                  90                  95    
 Trp Tyr Arg Ser Thr Leu Pro Ser Ala Val Ala Gly Arg Ser Gln Phe
             100                 105                 110        
 Asn Ala Arg Gln Thr Thr Phe Ile Asn Thr Glu Val Thr Arg Tyr Phe
         115                 120                 125            
 Ile Gln Glu His Ser His Trp His Gln Val Ser Ala Pro Leu Gly Trp
     130                 135                 140                
 Ser Ser Gln Arg Lys Glu Gln Ala Ala Ile Phe Ala Val Leu Gln Pro
 145                 150                 155                 160
 Ala Leu Val Met Pro Pro Ala Arg Ala Gln Asn Trp Ala Glu Ala Glu
                 165                 170                 175    
 Met Asp Glu Leu Thr Glu Val Gly Phe Arg Arg Trp Val Ile Thr Asn
             180                 185                 190        
 Phe Thr Glu Leu Lys Glu His Leu Leu Thr Gln Cys Lys Glu Ala Lys
         195                 200                 205            
 Asn Pro Asp Lys Thr Leu Asn Lys Leu Leu Thr Arg Ile Ser Ser Leu
     210                 215                 220                
 Val Gly Thr
 225        



      <210> 1155
      <211> 665
      <212> PRT
      <213> Homo sapiens


      <400> 1155
 Met Ala Gly His Thr Gln Gln Pro Ser Gly Arg Gly Asn Pro Arg Pro
   1               5                  10                  15    
 Ala Pro Ser Pro Ser Pro Val Pro Gly Thr Val Pro Gly Ala Ser Glu
              20                  25                  30        
 Arg Val Ala Leu Lys Lys Glu Ile Gly Leu Leu Ser Ala Cys Thr Ile
          35                  40                  45            
 Ile Ile Gly His Arg Glu Ala Ala Trp Leu Leu Ser Pro Gln Lys Gly
      50                  55                  60                
 Ala Leu Val Val Val Val Val Val Val Val Val Val Val Val Val Val
  65                  70                  75                  80
 Val Met Val Glu Val Val Val Val Gly Val Glu Lys Ala Asn Ser Thr
                  85                  90                  95    
 Ile Thr Leu Leu Phe Gln Asp Arg Leu Tyr Ala Leu Gly Val Leu Gln
             100                 105                 110        
 Asp Pro Lys Gly Ser Pro Asn Tyr Asn Phe Gly Asp Leu Ser Val Leu
         115                 120                 125            
 Gly Thr Leu Ile His Leu Phe Asn His Tyr Ile Leu Asn Gly Val Arg
     130                 135                 140                
 His Trp Leu Thr Cys Gln Arg His His Gly Gly Val Lys Thr Asp Lys
 145                 150                 155                 160
 Ile His Leu Leu Val Trp Glu Ser Arg Asn Lys Met Asn Lys Leu Asn
                 165                 170                 175    
 Ala Leu Val Gln Ile Ser Gly Glu Val Thr Gly Phe Met Cys Thr Asp
             180                 185                 190        
 Gly Asn Ile Ile Gly Ser Gly Ile Phe Ile Ser Pro Lys Gly Val Leu
         195                 200                 205            
 Glu His Ser Gly Ser Val Gly Leu Ala Leu Phe Val Trp Val Leu Gly
     210                 215                 220                
 Gly Gly Val Thr Ala Leu Gly Ser Leu Cys Tyr Ala Glu Leu Gly Val
 225                 230                 235                 240
 Ala Ile Pro Lys Ser Gly Gly Asp Tyr Ala Tyr Val Thr Glu Ile Phe
                 245                 250                 255    
 Gly Gly Leu Ala Gly Phe Leu Leu Leu Trp Ser Ala Val Leu Ile Met
             260                 265                 270        
 Tyr Pro Thr Ser Leu Ala Val Ile Ser Met Thr Phe Ser Asn Tyr Val
         275                 280                 285            
 Leu Gln Pro Val Phe Pro Asn Cys Ile Pro Pro Thr Thr Ala Ser Arg
     290                 295                 300                
 Val Leu Ser Met Ala Cys Leu Met Leu Leu Thr Trp Val Asn Ser Ser
 305                 310                 315                 320
 Ser Val Arg Trp Ala Thr Arg Ile Gln Asp Met Phe Thr Gly Gly Lys
                 325                 330                 335    
 Leu Leu Ala Leu Ser Leu Ile Ile Gly Val Gly Leu Leu Gln Ile Phe
             340                 345                 350        
 Gln Gly His Phe Glu Glu Leu Arg Pro Ser Asn Ala Phe Ala Phe Trp
         355                 360                 365            
 Met Thr Pro Ser Val Gly His Leu Ala Leu Ala Phe Leu Gln Gly Ser
     370                 375                 380                
 Phe Ala Phe Ser Gly Trp Asn Phe Leu Asn Tyr Val Thr Glu Glu Met
 385                 390                 395                 400
 Val Asp Ala Arg Lys Asn Leu Pro Arg Ala Ile Phe Ile Ser Ile Pro
                 405                 410                 415    
 Leu Val Thr Phe Val Tyr Thr Phe Thr Asn Ile Ala Tyr Phe Thr Ala
             420                 425                 430        
 Met Ser Pro Gln Glu Leu Leu Ser Ser Asn Ala Val Ala Val Thr Phe
         435                 440                 445            
 Gly Glu Lys Leu Leu Gly Tyr Phe Ser Trp Val Met Pro Val Ser Val
     450                 455                 460                
 Ala Leu Ser Thr Phe Gly Gly Ile Asn Gly Tyr Leu Phe Thr Tyr Ser
 465                 470                 475                 480
 Arg Leu Cys Phe Ser Gly Ala Arg Glu Gly His Leu Pro Ser Leu Leu
                 485                 490                 495    
 Ala Met Ile His Val Arg His Cys Thr Pro Ile Pro Ala Leu Leu Val
             500                 505                 510        
 Cys Cys Gly Ala Thr Ala Val Ile Met Leu Val Gly Asp Thr Tyr Thr
         515                 520                 525            
 Leu Ile Asn Tyr Val Ser Phe Ile Asn Tyr Leu Cys Tyr Gly Val Thr
     530                 535                 540                
 Ile Leu Gly Leu Leu Leu Leu Arg Trp Arg Arg Pro Ala Leu His Arg
 545                 550                 555                 560
 Pro Ile Lys Val Asn Leu Leu Ile Pro Val Ala Tyr Leu Val Phe Trp
                 565                 570                 575    
 Ala Phe Leu Leu Val Phe Ser Phe Ile Ser Glu Pro Met Val Cys Gly
             580                 585                 590        
 Val Gly Val Ile Ile Ile Leu Thr Gly Val Pro Ile Phe Phe Leu Gly
         595                 600                 605            
 Val Phe Trp Arg Ser Lys Pro Lys Cys Val His Arg Leu Thr Glu Ser
     610                 615                 620                
 Met Thr His Trp Gly Gln Glu Leu Cys Phe Val Val Tyr Pro Gln Asp
 625                 630                 635                 640
 Ala Pro Glu Glu Glu Glu Asn Gly Pro Cys Pro Pro Ser Leu Leu Pro
                 645                 650                 655    
 Ala Thr Asp Lys Pro Ser Lys Pro Gln
             660                 665



      <210> 1156
      <211> 459
      <212> PRT
      <213> Homo sapiens


      <400> 1156
 Met Asp Val Lys Glu Arg Arg Pro Tyr Cys Ser Leu Thr Lys Ser Arg
   1               5                  10                  15    
 Arg Glu Lys Glu Arg Arg Tyr Thr Asn Ser Ser Ala Asp Asn Glu Glu
              20                  25                  30        
 Cys Arg Val Pro Thr Gln Lys Ser Tyr Ser Ser Ser Glu Thr Leu Lys
          35                  40                  45            
 Ala Phe Asp His Asp Ser Ser Arg Leu Leu Tyr Gly Asn Arg Val Lys
      50                  55                  60                
 Asp Leu Val His Arg Glu Ala Asp Glu Phe Thr Arg Gln Gly Gln Asn
  65                  70                  75                  80
 Phe Thr Leu Arg Gln Leu Gly Val Cys Glu Pro Ala Thr Arg Arg Gly
                  85                  90                  95    
 Leu Ala Phe Cys Ala Glu Met Gly Leu Pro His Arg Gly Tyr Ser Ile
             100                 105                 110        
 Ser Ala Gly Ser Asp Ala Asp Thr Glu Asn Glu Ala Val Met Ser Pro
         115                 120                 125            
 Glu His Ala Met Arg Leu Trp Gly Arg Gly Val Lys Ser Gly Arg Ser
     130                 135                 140                
 Ser Cys Leu Ser Ser Arg Ser Asn Ser Ala Leu Thr Leu Thr Asp Thr
 145                 150                 155                 160
 Glu His Glu Asn Lys Ser Asp Ser Glu Asn Glu Gln Pro Ala Ser Asn
                 165                 170                 175    
 Gln Gly Gln Ser Thr Leu Gln Pro Leu Pro Pro Ser His Lys Gln His
             180                 185                 190        
 Ser Ala Gln His His Pro Ser Ile Thr Ser Leu Asn Arg Asn Ser Leu
         195                 200                 205            
 Thr Asn Arg Arg Asn Gln Ser Pro Ala Pro Pro Ala Ala Leu Pro Ala
     210                 215                 220                
 Glu Leu Gln Thr Thr Pro Glu Ser Val Gln Leu Gln Asp Ser Trp Val
 225                 230                 235                 240
 Leu Gly Ser Asn Val Pro Leu Glu Ser Arg His Phe Leu Phe Lys Thr
                 245                 250                 255    
 Gly Thr Gly Thr Thr Pro Leu Phe Ser Thr Ala Thr Pro Gly Tyr Thr
             260                 265                 270        
 Met Ala Ser Gly Ser Val Tyr Ser Pro Pro Thr Arg Pro Leu Pro Arg
         275                 280                 285            
 Asn Thr Leu Ser Arg Ser Ala Phe Lys Phe Lys Lys Ser Ser Lys Tyr
     290                 295                 300                
 Cys Ser Trp Lys Cys Thr Ala Leu Cys Ala Val Gly Val Ser Val Leu
 305                 310                 315                 320
 Leu Ala Ile Leu Leu Ser Tyr Phe Ile Ala Met His Leu Phe Gly Leu
                 325                 330                 335    
 Asn Trp Gln Leu Gln Gln Thr Glu Asn Asp Thr Phe Glu Asn Gly Lys
             340                 345                 350        
 Val Asn Ser Asp Thr Met Pro Thr Asn Thr Val Ser Leu Pro Ser Gly
         355                 360                 365            
 Asp Asn Gly Lys Leu Gly Gly Phe Thr Gln Glu Asn Asn Thr Ile Asp
     370                 375                 380                
 Ser Gly Glu Leu Asp Ile Gly Arg Arg Ala Ile Gln Glu Ile Pro Pro
 385                 390                 395                 400
 Gly Ile Phe Trp Arg Ser Gln Leu Phe Ile Asp Gln Pro Gln Phe Leu
                 405                 410                 415    
 Lys Phe Asn Ile Ser Leu Gln Lys Asp Ala Leu Ile Gly Val Tyr Gly
             420                 425                 430        
 Arg Lys Lys Leu Pro Pro Ser His Thr Gln Val Arg Leu Gly Phe Leu
         435                 440                 445            
 Ile Asn Lys Ile Lys Thr Ala Ser Cys Ile Phe
     450                 455                



      <210> 1157
      <211> 151
      <212> PRT
      <213> Homo sapiens


      <400> 1157
 Met Ala Ala Gln Lys Asp Gln Gln Arg Asp Ala Glu Ala Glu Gly Leu
   1               5                  10                  15    
 Ser Gly Thr Thr Leu Leu Pro Lys Leu Ile Pro Ser Gly Ala Gly Arg
              20                  25                  30        
 Glu Trp Leu Glu Arg Arg Arg Ala Thr Ile Arg Pro Trp Ser Thr Phe
          35                  40                  45            
 Val Asp Gln Gln Arg Phe Ser Arg Pro Arg Asn Leu Gly Glu Leu Cys
      50                  55                  60                
 Gln Arg Leu Val Arg Asn Val Glu Tyr Tyr Gln Ser Asn Tyr Val Phe
  65                  70                  75                  80
 Val Phe Leu Gly Leu Ile Leu Tyr Cys Val Val Thr Ser Pro Met Leu
                  85                  90                  95    
 Leu Val Ala Leu Ala Val Phe Phe Gly Ala Cys Tyr Ile Leu Tyr Leu
             100                 105                 110        
 Arg Thr Leu Glu Ser Lys Leu Val Leu Phe Gly Ala Thr Leu Val Val
         115                 120                 125            
 Ile Gly Ser His Ala Ala Phe His Gln Ile Glu Ala Val Asp Gly Glu
     130                 135                 140                
 Glu Leu Gln Met Glu Pro Val
 145                 150    



      <210> 1158
      <211> 330
      <212> PRT
      <213> Homo sapiens


      <400> 1158
 Met Val Gln Cys Phe Gly His Ile Ser Gly Gly His Ile Asn Pro Ala
   1               5                  10                  15    
 Val Thr Val Ala Met Val Cys Thr Arg Lys Ile Ser Ile Ala Lys Ser
              20                  25                  30        
 Val Phe Tyr Ile Ala Ala Gln Cys Leu Gly Ala Ile Ile Gly Ala Gly
          35                  40                  45            
 Ile Leu Tyr Leu Val Thr Pro Pro Thr Gly Ser Ala Thr Val Asp Leu
      50                  55                  60                
 Cys Cys Thr Lys Ala Val Ser Leu Leu Pro Gly Glu Pro Pro Gln Lys
  65                  70                  75                  80
 Val Pro Thr Gly Val Cys Gly Pro Leu Pro Ala Gly Thr Thr Gly Leu
                  85                  90                  95    
 Leu Leu Gly Lys Ser Ser Leu Gly Leu Lys Gly Val Gln Ile His Thr
             100                 105                 110        
 Gly Val Ile Asp Ser Asp Tyr Asn Gly Glu Ile Gln Ile Val Val Ser
         115                 120                 125            
 Thr Ser Val Pro Trp Lys Ala Glu Pro Gly Glu His Ile Ala Gln Phe
     130                 135                 140                
 Leu Ile Val Pro Phe Val Glu Met Gly Lys Ser Glu Ile Lys Arg Thr
 145                 150                 155                 160
 Gly Gly Phe Gly Ser Thr Asn Lys Gln Gly Lys Ala Ala Tyr Trp Val
                 165                 170                 175    
 Asn Gln Ile Thr Asp Lys His Pro Thr Cys Glu Ile Thr Ile Gln Gly
             180                 185                 190        
 Lys Lys Cys Lys Gly Leu Val Asp Thr Gly Ala Asp Ile Ser Ile Ile
         195                 200                 205            
 Ser Leu Gln His Trp Leu Ser Val Trp Pro Ile Gln Pro Ala Gln Phe
     210                 215                 220                
 Asn Ile Val Gly Val Gly Lys Ala Pro Glu Val Tyr Gln Ser Ser Tyr
 225                 230                 235                 240
 Ile Leu His Arg Glu Gly Pro Asp Gly Gln Pro Gly Thr Ile Gln Pro
                 245                 250                 255    
 Ile Ile Thr Ser Val Pro Ile Asn Leu Trp Gly Arg Asp Leu Leu Gln
             260                 265                 270        
 Gln Trp Gly Thr Gln Val Leu Ile Pro Glu Gln Leu Tyr Ser Pro Gln
         275                 280                 285            
 Asn Gln His Met Met His Glu Met Gly Tyr Val Pro Gly Met Gly Leu
     290                 295                 300                
 Glu Lys Asn Leu Gln Gly Leu Lys Glu Pro Leu Gln Ala Glu Arg Gln
 305                 310                 315                 320
 Asn Ser Arg Gln Arg Leu Gly Tyr His Phe
                 325                 330



      <210> 1159
      <211> 186
      <212> PRT
      <213> Homo sapiens


      <400> 1159
 Met Ala Ser Ser Ala Ala Ser Ser Glu His Phe Glu Lys Leu His Glu
   1               5                  10                  15    
 Ile Phe Arg Gly Leu His Glu Asp Leu Ser Phe Arg Asn Pro Met Met
              20                  25                  30        
 Ser Lys Leu Arg Asn Tyr Arg Lys Asp Leu Ala Lys Leu His Arg Glu
          35                  40                  45            
 Val Arg Ser Thr Pro Leu Thr Ala Thr Pro Gly Gly Arg Gly Asp Met
      50                  55                  60                
 Lys Tyr Gly Ile Tyr Ala Val Glu Asn Glu His Met Asn Arg Leu Gln
  65                  70                  75                  80
 Ser Gln Arg Ala Met Leu Leu Gln Gly Thr Glu Ser Leu Asn Arg Ala
                  85                  90                  95    
 Thr Gln Ser Ile Glu Arg Ser His Arg Ile Ala Thr Glu Thr Asp Gln
             100                 105                 110        
 Ile Gly Ser Glu Ile Ile Glu Glu Leu Gly Glu Gln Arg Asp Gln Leu
         115                 120                 125            
 Glu Arg Thr Lys Ser Arg Leu Val Asn Thr Ser Glu Asn Leu Ser Lys
     130                 135                 140                
 Ser Arg Lys Ile Leu Arg Ser Met Ser Arg Lys Val Thr Thr Asn Lys
 145                 150                 155                 160
 Leu Leu Leu Ser Ile Ile Ile Leu Leu Glu Leu Ala Ile Leu Gly Gly
                 165                 170                 175    
 Leu Val Tyr Tyr Lys Phe Phe Arg Ser His
             180                 185    



      <210> 1160
      <211> 3332
      <212> PRT
      <213> Homo sapiens


      <400> 1160
 Met Ala Ala Ala Ala Arg Pro Arg Gly Arg Ala Leu Gly Pro Val Leu
   1               5                  10                  15    
 Pro Pro Thr Pro Leu Leu Leu Leu Val Leu Arg Val Leu Pro Ala Cys
              20                  25                  30        
 Gly Ala Thr Ala Arg Asp Pro Gly Ala Ala Ala Gly Leu Ser Leu His
          35                  40                  45            
 Pro Thr Tyr Phe Asn Leu Ala Glu Ala Ala Arg Ile Trp Ala Thr Ala
      50                  55                  60                
 Thr Cys Gly Glu Arg Gly Pro Gly Glu Gly Arg Pro Gln Pro Glu Leu
  65                  70                  75                  80
 Tyr Cys Lys Leu Val Gly Gly Pro Thr Ala Pro Gly Ser Gly His Thr
                  85                  90                  95    
 Ile Gln Gly Gln Phe Cys Asp Tyr Cys Asn Ser Glu Asp Pro Arg Lys
             100                 105                 110        
 Ala His Pro Val Thr Asn Ala Ile Asp Gly Ser Glu Arg Trp Trp Gln
         115                 120                 125            
 Ser Pro Pro Leu Ser Ser Gly Thr Gln Tyr Asn Arg Val Asn Leu Thr
     130                 135                 140                
 Leu Asp Leu Gly Gln Leu Phe His Val Ala Tyr Ile Leu Ile Lys Phe
 145                 150                 155                 160
 Ala Asn Ser Pro Arg Pro Asp Leu Trp Val Leu Glu Arg Ser Val Asp
                 165                 170                 175    
 Phe Gly Ser Thr Tyr Ser Pro Trp Gln Tyr Phe Ala His Ser Lys Val
             180                 185                 190        
 Asp Cys Leu Lys Glu Phe Gly Arg Glu Ala Asn Met Ala Val Thr Arg
         195                 200                 205            
 Asp Asp Asp Val Leu Cys Val Thr Glu Tyr Ser Arg Ile Val Pro Leu
     210                 215                 220                
 Glu Asn Gly Glu Val Val Val Ser Leu Ile Asn Gly Arg Pro Gly Ala
 225                 230                 235                 240
 Lys Asn Phe Thr Phe Ser His Thr Leu Arg Glu Phe Thr Lys Ala Thr
                 245                 250                 255    
 Asn Ile Arg Leu Arg Phe Leu Arg Thr Asn Thr Leu Leu Gly His Leu
             260                 265                 270        
 Ile Ser Lys Ala Gln Arg Asp Pro Thr Val Thr Arg Arg Tyr Tyr Tyr
         275                 280                 285            
 Ser Ile Lys Asp Ile Ser Ile Gly Gly Gln Cys Val Cys Asn Gly His
     290                 295                 300                
 Ala Glu Val Cys Asn Ile Asn Asn Pro Glu Lys Leu Phe Arg Cys Glu
 305                 310                 315                 320
 Cys Gln His His Thr Cys Gly Glu Thr Cys Asp Arg Cys Cys Thr Gly
                 325                 330                 335    
 Tyr Asn Gln Arg Arg Trp Arg Pro Ala Ala Trp Glu Gln Ser His Glu
             340                 345                 350        
 Cys Glu Ala Cys Asn Cys His Gly His Ala Ser Asn Cys Tyr Tyr Asp
         355                 360                 365            
 Pro Asp Val Glu Arg Gln Gln Ala Ser Leu Asn Thr Gln Gly Ile Tyr
     370                 375                 380                
 Ala Gly Gly Gly Val Cys Ile Asn Cys Gln His Asn Thr Ala Gly Val
 385                 390                 395                 400
 Asn Cys Glu Gln Cys Ala Lys Gly Tyr Tyr Arg Pro Tyr Gly Val Pro
                 405                 410                 415    
 Val Asp Ala Pro Asp Gly Cys Ile Pro Cys Ser Cys Asp Pro Glu His
             420                 425                 430        
 Ala Asp Gly Cys Glu Gln Gly Ser Gly Arg Cys His Cys Lys Pro Asn
         435                 440                 445            
 Phe His Gly Asp Asn Cys Glu Lys Cys Ala Ile Gly Tyr Asn Phe Pro
     450                 455                 460                
 Phe Cys Leu Arg Thr Pro Ile Phe Pro Val Ser Thr Pro Ser Ser Glu
 465                 470                 475                 480
 Asp Pro Val Ala Gly Asp Ile Lys Gly Cys Asp Cys Asn Leu Glu Gly
                 485                 490                 495    
 Val Leu Pro Glu Ile Cys Asp Ala His Gly Arg Cys Leu Cys Arg Pro
             500                 505                 510        
 Gly Val Glu Gly Pro Arg Cys Asp Thr Cys Arg Ser Gly Phe Tyr Ser
         515                 520                 525            
 Phe Pro Ile Cys Gln Ala Cys Trp Cys Ser Ala Leu Gly Ser Tyr Gln
     530                 535                 540                
 Met Pro Cys Ser Ser Val Thr Gly Gln Cys Glu Cys Arg Pro Gly Val
 545                 550                 555                 560
 Thr Gly Gln Arg Cys Asp Arg Cys Leu Ser Gly Ala Tyr Asp Phe Pro
                 565                 570                 575    
 His Cys Gln Gly Ser Ser Ser Ala Cys Asp Pro Ala Gly Thr Ile Asn
             580                 585                 590        
 Trp Asn Leu Gly Tyr Cys Gln Cys Lys Leu His Val Glu Gly Pro Thr
         595                 600                 605            
 Cys Ser Arg Cys Lys Leu Leu Tyr Trp Asn Leu Asp Lys Glu Asn Pro
     610                 615                 620                
 Ser Gly Cys Ser Glu Cys Lys Cys His Lys Gly Gly Thr Val Ser Gly
 625                 630                 635                 640
 Thr Gly Glu Cys Arg Gln Gly Asp Gly Asp Cys His Cys Lys Ser His
                 645                 650                 655    
 Val Gly Gly Asp Ser Cys Asp Thr Cys Glu Asp Gly Tyr Phe Ala Leu
             660                 665                 670        
 Glu Lys Ser Asn Tyr Phe Gly Cys Gln Gly Cys Gln Cys Asp Ile Gly
         675                 680                 685            
 Gly Ala Leu Ser Ser Met Cys Ser Gly Pro Ser Gly Val Cys Gln Cys
     690                 695                 700                
 Arg Glu His Val Val Gly Lys Val Cys Gln Arg Pro Glu Asn Asn Tyr
 705                 710                 715                 720
 Tyr Phe Pro Asp Leu His His Met Lys Tyr Glu Ile Glu Asp Gly Ser
                 725                 730                 735    
 Thr Pro Asn Gly Arg Asp Leu Arg Phe Gly Phe Asp Pro Leu Ala Phe
             740                 745                 750        
 Pro Glu Phe Ser Trp Arg Gly Tyr Ala Gln Met Ala Ser Val Gln Asn
         755                 760                 765            
 Asp Val Arg Ile Thr Leu Asn Val Gly Lys Ser Ser Gly Ser Leu Phe
     770                 775                 780                
 Arg Val Ile Leu Arg Tyr Val Asn Pro Gly Thr Glu Ala Val Ser Gly
 785                 790                 795                 800
 His Ile Thr Ile Tyr Pro Ser Trp Gly Ala Ala Gln Ser Lys Glu Ile
                 805                 810                 815    
 Ile Phe Leu Pro Ser Lys Glu Pro Ala Phe Val Thr Leu Pro Gly Asn
             820                 825                 830        
 Gly Phe Ala Asp Pro Phe Ser Ile Thr Pro Gly Met Trp Val Ala Cys
         835                 840                 845            
 Ile Lys Ala Glu Gly Val Leu Leu Asp Tyr Leu Val Leu Leu Pro Arg
     850                 855                 860                
 Asp Tyr Tyr Glu Ala Ser Asp Leu Gln Leu Pro Val Thr Glu Pro Cys
 865                 870                 875                 880
 Ala Tyr Ala Gly Pro Pro Gln Glu Asn Cys Leu Leu Tyr Gln His Leu
                 885                 890                 895    
 Pro Val Thr Arg Phe Pro Cys Thr Arg Ser Cys Glu Ala Arg His Phe
             900                 905                 910        
 Leu Leu Asp Gly Glu Pro Arg Pro Val Ala Val Arg Gln Pro Thr Pro
         915                 920                 925            
 Ala His Pro Val Met Val Asp Leu Ser Gly Arg Glu Val Glu Leu His
     930                 935                 940                
 Leu Arg Val Arg Ile Pro Gln Val Gly Pro Tyr Val Val Val Val Glu
 945                 950                 955                 960
 Tyr Ser Thr Glu Ala Ala Gln Leu Phe Val Val Asp Ala Asn Val Lys
                 965                 970                 975    
 Ser Ser Gly Ser Val Leu Ala Gly Gln Val Asn Ile Tyr Ser Cys Asn
             980                 985                 990        
 Tyr Ser Val Leu Cys Arg Ser Ala Val Ile Asp His Met Ser Arg Ile
         995                1000                1005            
 Ala Met Tyr Glu Leu Leu Thr Asp Ala Asp Ile Gln Leu Lys Gly His
    1010                1015                1020                
 Met Ala Arg Phe Leu Leu His Gln Val Cys Ile Ile Pro Ile Glu Glu
1025                1030                1035                1040
 Tyr Ser Ala Glu Tyr Val Arg Pro Gln Val His Cys Ile Ala Ser Tyr
                1045                1050                1055    
 Gly Arg Phe Val Asn Gln Ser Ala Thr Cys Val Ser Leu Ala His Glu
            1060                1065                1070        
 Thr Pro Pro Thr Ala Leu Ile Leu Asp Val Leu Ser Gly Arg Pro Phe
        1075                1080                1085            
 Pro His Leu Pro Gln Gln Ser Ser Pro Ser Val Asp Val Leu Pro Gly
    1090                1095                1100                
 Val Thr Leu Lys Ala Pro Gln Asn Gln Val Thr Leu Arg Gly Arg Val
1105                1110                1115                1120
 Pro His Leu Gly Arg Tyr Val Phe Val Ile His Phe Tyr Gln Ala Ala
                1125                1130                1135    
 His Pro Thr Phe Pro Ala Gln Val Ser Val Asp Gly Gly Trp Pro Arg
            1140                1145                1150        
 Ala Gly Ser Phe His Ala Ser Phe Cys Pro His Val Leu Gly Cys Arg
        1155                1160                1165            
 Asp Gln Val Ile Ala Glu Gly Gln Ile Glu Phe Asp Ile Ser Glu Pro
    1170                1175                1180                
 Glu Val Ala Ala Thr Val Lys Val Pro Glu Gly Lys Ser Leu Val Leu
1185                1190                1195                1200
 Val Arg Val Leu Val Val Pro Ala Glu Asn Tyr Asp Tyr Gln Ile Leu
                1205                1210                1215    
 His Lys Lys Ser Met Asp Lys Ser Leu Glu Phe Ile Thr Asn Cys Gly
            1220                1225                1230        
 Lys Asn Ser Phe Tyr Leu Asp Pro Gln Thr Ala Ser Arg Phe Cys Lys
        1235                1240                1245            
 Asn Ser Ala Arg Ser Leu Val Ala Phe Tyr His Lys Gly Ala Leu Pro
    1250                1255                1260                
 Cys Glu Cys His Pro Thr Gly Ala Thr Gly Pro His Cys Ser Pro Glu
1265                1270                1275                1280
 Gly Gly Gln Cys Pro Cys Gln Pro Asn Val Ile Gly Arg Gln Cys Thr
                1285                1290                1295    
 Arg Cys Ala Thr Gly His Tyr Gly Phe Pro Arg Cys Lys Pro Cys Ser
            1300                1305                1310        
 Cys Gly Arg Arg Leu Cys Glu Glu Met Thr Gly Gln Cys Arg Cys Pro
        1315                1320                1325            
 Pro Arg Thr Val Arg Pro Gln Cys Glu Val Cys Glu Thr His Ser Phe
    1330                1335                1340                
 Ser Phe His Pro Met Ala Gly Cys Glu Gly Cys Asn Cys Ser Arg Arg
1345                1350                1355                1360
 Gly Thr Ile Glu Ala Ala Met Pro Glu Cys Asp Arg Asp Ser Gly Gln
                1365                1370                1375    
 Cys Arg Cys Lys Pro Arg Ile Thr Gly Arg Gln Cys Asp Arg Cys Ala
            1380                1385                1390        
 Ser Gly Phe Tyr Arg Phe Pro Glu Cys Val Pro Cys Asn Cys Asn Arg
        1395                1400                1405            
 Asp Gly Thr Glu Pro Gly Val Cys Asp Pro Gly Thr Gly Ala Cys Leu
    1410                1415                1420                
 Cys Lys Glu Asn Val Glu Gly Thr Glu Cys Asn Val Cys Arg Glu Gly
1425                1430                1435                1440
 Ser Phe His Leu Asp Pro Ala Asn Leu Lys Gly Cys Thr Ser Cys Phe
                1445                1450                1455    
 Cys Phe Gly Val Asn Asn Gln Cys His Ser Ser His Lys Arg Arg Thr
            1460                1465                1470        
 Lys Phe Val Asp Met Leu Gly Trp His Leu Glu Thr Ala Asp Arg Val
        1475                1480                1485            
 Asp Ile Pro Val Ser Phe Asn Pro Gly Ser Asn Ser Met Val Ala Asp
    1490                1495                1500                
 Leu Gln Glu Leu Pro Ala Thr Ile His Ser Ala Ser Trp Val Ala Pro
1505                1510                1515                1520
 Thr Ser Tyr Leu Gly Asp Lys Val Ser Ser Tyr Gly Gly Tyr Leu Thr
                1525                1530                1535    
 Tyr Gln Ala Lys Ser Phe Gly Leu Pro Gly Asp Met Val Leu Leu Glu
            1540                1545                1550        
 Lys Lys Pro Asp Val Gln Leu Thr Gly Gln His Met Ser Ile Ile Tyr
        1555                1560                1565            
 Glu Glu Thr Asn Thr Pro Arg Pro Asp Arg Leu His His Gly Arg Val
    1570                1575                1580                
 His Val Val Glu Gly Asn Phe Arg His Ala Ser Ser Arg Ala Pro Val
1585                1590                1595                1600
 Ser Arg Glu Glu Leu Met Thr Val Leu Ser Arg Leu Ala Asp Val Arg
                1605                1610                1615    
 Ile Gln Gly Leu Tyr Phe Thr Glu Thr Gln Arg Leu Thr Leu Ser Glu
            1620                1625                1630        
 Val Gly Leu Glu Glu Ala Ser Asp Thr Gly Ser Gly Arg Ile Ala Leu
        1635                1640                1645            
 Ala Val Glu Ile Cys Ala Cys Pro Pro Ala Tyr Ala Gly Asp Ser Cys
    1650                1655                1660                
 Gln Gly Cys Ser Pro Gly Tyr Tyr Arg Asp His Lys Gly Leu Tyr Thr
1665                1670                1675                1680
 Gly Arg Cys Val Pro Cys Asn Cys Asn Gly His Ser Asn Gln Cys Gln
                1685                1690                1695    
 Asp Gly Ser Gly Ile Cys Val Asn Cys Gln His Asn Thr Ala Gly Glu
            1700                1705                1710        
 His Cys Glu Arg Cys Gln Glu Gly Tyr Tyr Gly Asn Ala Val His Gly
        1715                1720                1725            
 Ser Cys Arg Ala Cys Pro Cys Pro His Thr Asn Ser Phe Ala Thr Gly
    1730                1735                1740                
 Cys Val Val Asn Gly Gly Asp Val Arg Cys Ser Cys Lys Ala Gly Tyr
1745                1750                1755                1760
 Thr Gly Thr Gln Cys Glu Arg Cys Ala Pro Gly Tyr Phe Gly Asn Pro
                1765                1770                1775    
 Gln Lys Phe Gly Gly Ser Cys Gln Pro Cys Ser Cys Asn Ser Asn Gly
            1780                1785                1790        
 Gln Leu Gly Ser Cys His Pro Leu Thr Gly Asp Cys Ile Asn Gln Glu
        1795                1800                1805            
 Pro Lys Asp Ser Ser Pro Ala Glu Glu Cys Asp Asp Cys Asp Ser Cys
    1810                1815                1820                
 Val Met Thr Leu Leu Asn Asp Leu Ala Thr Met Gly Glu Gln Leu Arg
1825                1830                1835                1840
 Leu Val Lys Ser Gln Leu Gln Gly Leu Ser Ala Ser Ala Gly Leu Leu
                1845                1850                1855    
 Glu Gln Met Arg His Met Glu Thr Gln Ala Lys Asp Leu Arg Asn Gln
            1860                1865                1870        
 Leu Leu Asn Tyr Arg Ser Ala Ile Ser Asn His Gly Ser Lys Ile Glu
        1875                1880                1885            
 Gly Leu Glu Arg Glu Leu Thr Asp Leu Asn Gln Glu Phe Glu Thr Leu
    1890                1895                1900                
 Gln Glu Lys Ala Gln Val Asn Ser Arg Lys Ala Gln Thr Leu Asn Asn
1905                1910                1915                1920
 Asn Val Asn Arg Ala Thr Gln Ser Ala Lys Glu Leu Asp Val Lys Ile
                1925                1930                1935    
 Lys Asn Val Ile Arg Asn Val His Ile Leu Leu Lys Gln Ile Ser Gly
            1940                1945                1950        
 Thr Asp Gly Glu Gly Asn Asn Val Pro Ser Gly Asp Phe Ser Arg Glu
        1955                1960                1965            
 Trp Ala Glu Ala Gln Arg Met Met Arg Glu Leu Arg Asn Arg Asn Phe
    1970                1975                1980                
 Gly Lys His Leu Arg Glu Ala Glu Ala Asp Lys Arg Glu Ser Gln Leu
1985                1990                1995                2000
 Leu Leu Asn Arg Ile Arg Thr Trp Gln Lys Thr His Gln Gly Glu Asn
                2005                2010                2015    
 Asn Gly Leu Ala Asn Ser Ile Arg Asp Ser Leu Asn Glu Tyr Glu Ala
            2020                2025                2030        
 Lys Leu Ser Asp Leu Arg Ala Arg Leu Gln Glu Ala Ala Ala Gln Ala
        2035                2040                2045            
 Lys Gln Ala Asn Gly Leu Asn Gln Glu Asn Glu Arg Ala Leu Gly Ala
    2050                2055                2060                
 Ile Gln Arg Gln Val Lys Glu Ile Asn Ser Leu Gln Ser Asp Phe Thr
2065                2070                2075                2080
 Lys Tyr Leu Thr Thr Ala Asp Ser Ser Leu Leu Gln Thr Asn Ile Ala
                2085                2090                2095    
 Leu Gln Leu Met Glu Lys Ser Gln Lys Glu Tyr Glu Lys Leu Ala Ala
            2100                2105                2110        
 Ser Leu Asn Glu Ala Arg Gln Glu Leu Ser Asp Lys Val Arg Glu Leu
        2115                2120                2125            
 Ser Arg Ser Ala Gly Lys Thr Ser Leu Val Glu Glu Ala Glu Lys His
    2130                2135                2140                
 Ala Arg Ser Leu Gln Glu Leu Ala Lys Gln Leu Glu Glu Ile Lys Arg
2145                2150                2155                2160
 Asn Ala Ser Gly Asp Glu Leu Val Arg Cys Ala Val Asp Ala Ala Thr
                2165                2170                2175    
 Ala Tyr Glu Asn Ile Leu Asn Ala Ile Lys Ala Ala Glu Asp Ala Ala
            2180                2185                2190        
 Asn Arg Ala Ala Ser Ala Ser Glu Ser Ala Leu Gln Thr Val Ile Lys
        2195                2200                2205            
 Glu Asp Leu Pro Arg Lys Ala Lys Thr Leu Ser Ser Asn Ser Asp Lys
    2210                2215                2220                
 Leu Leu Asn Glu Ala Lys Met Thr Gln Lys Lys Leu Lys Gln Glu Val
2225                2230                2235                2240
 Ser Pro Ala Leu Asn Asn Leu Gln Gln Thr Leu Asn Ile Val Thr Val
                2245                2250                2255    
 Gln Lys Glu Val Ile Asp Thr Asn Leu Thr Thr Leu Arg Asp Gly Leu
            2260                2265                2270        
 His Gly Ile Gln Arg Gly Asp Ile Asp Ala Met Ile Ser Ser Ala Lys
        2275                2280                2285            
 Ser Met Val Arg Lys Ala Asn Asp Ile Thr Asp Glu Val Leu Asp Gly
    2290                2295                2300                
 Leu Asn Pro Ile Gln Thr Asp Val Glu Arg Ile Lys Asp Thr Tyr Gly
2305                2310                2315                2320
 Arg Thr Gln Asn Glu Asp Phe Lys Lys Ala Leu Thr Asp Ala Asp Asn
                2325                2330                2335    
 Ser Val Asn Lys Leu Thr Asn Lys Leu Pro Asp Leu Trp Arg Lys Ile
            2340                2345                2350        
 Glu Ser Ile Asn Gln Gln Leu Leu Pro Leu Gly Asn Ile Ser Asp Asn
        2355                2360                2365            
 Met Asp Arg Ile Arg Glu Leu Ile Gln Gln Ala Arg Asp Ala Ala Ser
    2370                2375                2380                
 Lys Val Ala Val Pro Met Arg Phe Asn Gly Lys Ser Gly Val Glu Val
2385                2390                2395                2400
 Arg Leu Pro Asn Asp Leu Glu Asp Leu Lys Gly Tyr Thr Ser Leu Ser
                2405                2410                2415    
 Leu Phe Leu Gln Arg Pro Asn Ser Arg Glu Asn Gly Gly Thr Glu Asn
            2420                2425                2430        
 Met Phe Val Met Tyr Leu Gly Asn Lys Asp Ala Ser Arg Asp Tyr Ile
        2435                2440                2445            
 Gly Met Ala Val Val Asp Gly Gln Leu Thr Cys Val Tyr Asn Leu Gly
    2450                2455                2460                
 Asp Arg Glu Ala Glu Leu Gln Val Asp Gln Ile Leu Thr Lys Ser Glu
2465                2470                2475                2480
 Thr Lys Glu Ala Val Met Asp Arg Val Lys Phe Gln Arg Ile Tyr Gln
                2485                2490                2495    
 Phe Ala Arg Leu Asn Tyr Thr Lys Gly Ala Thr Ser Ser Lys Pro Glu
            2500                2505                2510        
 Thr Pro Gly Val Tyr Asp Met Asp Gly Arg Asn Ser Asn Thr Leu Leu
        2515                2520                2525            
 Asn Leu Asp Pro Glu Asn Val Val Phe Tyr Val Gly Gly Tyr Pro Pro
    2530                2535                2540                
 Asp Phe Lys Leu Pro Ser Arg Leu Ser Phe Pro Pro Tyr Lys Gly Cys
2545                2550                2555                2560
 Ile Glu Leu Asp Asp Leu Asn Glu Asn Val Leu Ser Leu Tyr Asn Phe
                2565                2570                2575    
 Lys Lys Thr Phe Asn Leu Asn Thr Thr Glu Val Glu Pro Cys Arg Arg
            2580                2585                2590        
 Arg Lys Glu Glu Ser Asp Lys Asn Tyr Phe Glu Gly Thr Gly Tyr Ala
        2595                2600                2605            
 Arg Val Pro Thr Gln Pro His Ala Pro Ile Pro Thr Phe Gly Gln Thr
    2610                2615                2620                
 Ile Gln Thr Thr Val Asp Arg Gly Leu Leu Phe Phe Ala Glu Asn Gly
2625                2630                2635                2640
 Asp Arg Phe Ile Ser Leu Asn Ile Glu Asp Gly Lys Leu Met Val Arg
                2645                2650                2655    
 Tyr Lys Leu Asn Ser Glu Leu Pro Lys Glu Arg Gly Val Gly Asp Ala
            2660                2665                2670        
 Ile Asn Asn Gly Arg Asp His Ser Ile Gln Ile Lys Ile Gly Lys Leu
        2675                2680                2685            
 Gln Lys Arg Met Trp Ile Asn Val Asp Val Gln Asn Thr Ile Ile Asp
    2690                2695                2700                
 Gly Glu Val Phe Asp Phe Ser Thr Tyr Tyr Leu Gly Gly Ile Pro Ile
2705                2710                2715                2720
 Ala Ile Arg Glu Arg Phe Asn Ile Ser Thr Pro Ala Phe Arg Gly Cys
                2725                2730                2735    
 Met Lys Asn Leu Lys Lys Thr Ser Gly Val Val Arg Leu Asn Asp Thr
            2740                2745                2750        
 Val Gly Val Thr Lys Lys Cys Ser Glu Asp Trp Lys Leu Val Arg Ser
        2755                2760                2765            
 Ala Ser Phe Ser Arg Gly Gly Gln Leu Ser Phe Thr Asp Leu Gly Leu
    2770                2775                2780                
 Pro Pro Thr Asp His Leu Gln Ala Ser Phe Gly Phe Gln Thr Phe Gln
2785                2790                2795                2800
 Pro Ser Gly Ile Leu Leu Asp His Gln Thr Trp Thr Arg Asn Leu Gln
                2805                2810                2815    
 Val Thr Leu Glu Asp Gly Tyr Ile Glu Leu Ser Thr Ser Asp Ser Gly
            2820                2825                2830        
 Gly Pro Ile Phe Lys Ser Pro Gln Thr Tyr Met Asp Gly Leu Leu His
        2835                2840                2845            
 Tyr Val Ser Val Ile Ser Asp Asn Ser Gly Leu Arg Leu Leu Ile Asp
    2850                2855                2860                
 Asp Gln Leu Leu Arg Asn Ser Lys Arg Leu Lys His Ile Ser Ser Ser
2865                2870                2875                2880
 Arg Gln Ser Leu Arg Leu Gly Gly Ser Asn Phe Glu Gly Cys Ile Ser
                2885                2890                2895    
 Asn Val Phe Val Gln Arg Leu Ser Leu Ser Pro Glu Val Leu Asp Leu
            2900                2905                2910        
 Thr Ser Asn Ser Leu Lys Arg Asp Val Ser Leu Gly Gly Cys Ser Leu
        2915                2920                2925            
 Asn Lys Pro Pro Phe Leu Met Leu Leu Lys Gly Ser Thr Arg Phe Asn
    2930                2935                2940                
 Lys Thr Lys Thr Phe Arg Ile Asn Gln Leu Leu Gln Asp Thr Pro Val
2945                2950                2955                2960
 Ala Ser Pro Arg Ser Val Lys Val Trp Gln Asp Ala Cys Ser Pro Leu
                2965                2970                2975    
 Pro Lys Thr Gln Ala Asn His Gly Ala Leu Gln Phe Gly Asp Ile Pro
            2980                2985                2990        
 Thr Ser His Leu Leu Phe Lys Leu Pro Gln Glu Leu Leu Lys Pro Arg
        2995                3000                3005            
 Ser Gln Phe Ala Val Asp Met Gln Thr Thr Ser Ser Arg Gly Leu Val
    3010                3015                3020                
 Phe His Thr Gly Thr Lys Asn Ser Phe Met Ala Leu Tyr Leu Ser Lys
3025                3030                3035                3040
 Gly Arg Leu Val Phe Ala Leu Gly Thr Asp Gly Lys Lys Leu Arg Ile
                3045                3050                3055    
 Lys Ser Lys Glu Lys Cys Asn Asp Gly Lys Trp His Thr Val Val Phe
            3060                3065                3070        
 Gly His Asp Gly Glu Lys Gly Arg Leu Val Val Asp Gly Leu Arg Ala
        3075                3080                3085            
 Arg Glu Gly Ser Leu Pro Gly Asn Ser Thr Ile Ser Ile Arg Ala Pro
    3090                3095                3100                
 Val Tyr Leu Gly Ser Pro Pro Ser Gly Lys Pro Lys Ser Leu Pro Thr
3105                3110                3115                3120
 Asn Ser Phe Val Gly Cys Leu Lys Asn Phe Gln Leu Asp Ser Lys Pro
                3125                3130                3135    
 Leu Tyr Thr Pro Ser Ser Ser Phe Gly Val Ser Ser Cys Leu Gly Gly
            3140                3145                3150        
 Pro Leu Glu Lys Gly Ile Tyr Phe Ser Glu Glu Gly Gly His Val Val
        3155                3160                3165            
 Leu Ala His Ser Val Leu Leu Gly Pro Glu Phe Lys Leu Val Phe Ser
    3170                3175                3180                
 Ile Arg Pro Arg Ser Leu Thr Gly Ile Leu Ile His Ile Gly Ser Gln
3185                3190                3195                3200
 Pro Gly Lys His Leu Cys Val Tyr Leu Glu Ala Gly Lys Val Thr Ala
                3205                3210                3215    
 Ser Met Asp Ser Gly Ala Gly Gly Thr Ser Thr Ser Val Thr Pro Lys
            3220                3225                3230        
 Gln Ser Leu Cys Asp Gly Gln Trp His Ser Val Ala Val Thr Ile Lys
        3235                3240                3245            
 Gln His Ile Leu His Leu Glu Leu Asp Thr Asp Ser Ser Tyr Thr Ala
    3250                3255                3260                
 Gly Gln Ile Pro Phe Pro Pro Ala Ser Thr Gln Glu Pro Leu His Leu
3265                3270                3275                3280
 Gly Gly Ala Pro Ala Asn Leu Thr Thr Leu Arg Ile Pro Val Trp Lys
                3285                3290                3295    
 Ser Phe Phe Gly Cys Leu Arg Asn Ile His Val Asn His Ile Pro Val
            3300                3305                3310        
 Pro Val Thr Glu Ala Leu Glu Val Gln Gly Pro Val Ser Leu Asn Gly
        3315                3320                3325            
 Cys Pro Asp Gln
    3330        



      <210> 1161
      <211> 352
      <212> PRT
      <213> Homo sapiens


      <400> 1161
 Met Pro Ser Gly Cys Arg Cys Leu His Leu Val Cys Leu Leu Cys Ile
   1               5                  10                  15    
 Leu Gly Ala Pro Gly Gln Pro Val Arg Ala Asp Asp Cys Ser Ser His
              20                  25                  30        
 Cys Asp Leu Ala His Gly Cys Cys Ala Pro Asp Gly Ser Cys Arg Cys
          35                  40                  45            
 Asp Pro Gly Trp Glu Gly Leu His Cys Glu Arg Cys Val Arg Met Pro
      50                  55                  60                
 Gly Cys Gln His Gly Thr Cys His Gln Pro Trp Gln Cys Ile Cys His
  65                  70                  75                  80
 Ser Gly Trp Ala Gly Lys Phe Cys Asp Lys Gly Phe His Gly Arg Asp
                  85                  90                  95    
 Cys Glu Arg Lys Ala Gly Pro Cys Glu Gln Ala Gly Ser Pro Cys Arg
             100                 105                 110        
 Asn Gly Gly Gln Cys Gln Asp Asp Gln Gly Phe Ala Leu Asn Phe Thr
         115                 120                 125            
 Cys Arg Cys Leu Val Gly Phe Val Gly Ala Arg Cys Glu Val Asn Val
     130                 135                 140                
 Asp Asp Cys Leu Met Arg Pro Cys Ala Asn Gly Ala Thr Cys Leu Asp
 145                 150                 155                 160
 Gly Ile Asn Arg Phe Ser Cys Leu Cys Pro Glu Gly Phe Ala Gly Arg
                 165                 170                 175    
 Phe Cys Thr Ile Asn Leu Asp Asp Cys Ala Ser Arg Pro Cys Gln Arg
             180                 185                 190        
 Gly Ala Arg Cys Arg Asp Arg Val His Asp Phe Asp Cys Leu Cys Pro
         195                 200                 205            
 Ser Gly Tyr Gly Gly Lys Thr Cys Glu Leu Val Leu Pro Val Pro Asp
     210                 215                 220                
 Pro Pro Thr Thr Val Asp Thr Pro Leu Gly Pro Thr Ser Ala Val Val
 225                 230                 235                 240
 Val Pro Ala Thr Gly Pro Ala Pro His Ser Ala Gly Ala Gly Leu Leu
                 245                 250                 255    
 Arg Ile Ser Val Lys Glu Val Val Arg Arg Gln Glu Ala Gly Leu Gly
             260                 265                 270        
 Glu Pro Ser Leu Val Ala Leu Val Val Phe Gly Ala Leu Thr Ala Ala
         275                 280                 285            
 Leu Val Leu Ala Thr Val Leu Leu Thr Leu Arg Ala Trp Arg Arg Gly
     290                 295                 300                
 Val Cys Pro Pro Gly Pro Cys Cys Tyr Pro Ala Pro His Tyr Ala Pro
 305                 310                 315                 320
 Ala Cys Gln Asp Gln Glu Cys Gln Val Ser Met Leu Pro Ala Gly Leu
                 325                 330                 335    
 Pro Leu Pro Arg Asp Leu Pro Pro Glu Pro Gly Lys Thr Thr Ala Leu
             340                 345                 350        





      <210> 1162
      <211> 171
      <212> PRT
      <213> Homo sapiens


      <400> 1162
 Met Lys Thr Ser Ala His Pro Gly Gln Lys His Pro Asp Phe Ser Met
   1               5                  10                  15    
 Gly Leu Leu Phe Pro Leu Leu Ala Ala Leu Glu Val Cys Ser Cys Gly
              20                  25                  30        
 Ser Ser Gly Ser Leu Gly Tyr Asn Leu Pro Gln Asn His Gly Leu Leu
          35                  40                  45            
 Gly Arg Asn Thr Leu Val Leu Leu Gly Gln Met Arg Arg Ile Ser Pro
      50                  55                  60                
 Phe Leu Cys Leu Lys Asp Arg Ser Asp Phe Arg Phe Pro Gln Glu Lys
  65                  70                  75                  80
 Val Glu Val Ser Gln Leu Gln Lys Ala Gln Ala Met Ser Phe Leu Tyr
                  85                  90                  95    
 Asp Val Leu Gln Gln Val Phe Asn Phe Ser His Lys Ala Leu Leu Cys
             100                 105                 110        
 Cys Met Glu His Asp Leu Pro Gly Pro Thr Pro His Phe Met Ser Ser
         115                 120                 125            
 Ala Ala Gly Thr Pro Gly Asp Leu Leu Gly Ala Gly Asp Gly Arg Arg
     130                 135                 140                
 Arg Ser Trp Gly Gln Trp Val Ile Glu Gly Ser Thr Leu Ala Leu Arg
 145                 150                 155                 160
 Arg Tyr Phe Gln Glu Ser Ile Ser Thr Leu Glu
                 165                 170    



      <210> 1163
      <211> 159
      <212> PRT
      <213> Homo sapiens


      <400> 1163
 Met Glu Tyr Met Pro Met Glu Met Cys Ser Leu Pro Met Ala Arg Tyr
   1               5                  10                  15    
 Tyr Ile Ile Lys Tyr Ala Asp Gln Lys Ala Leu Tyr Thr Arg Asp Gly
              20                  25                  30        
 Gln Leu Leu Val Gly Asp Pro Val Ala Asp Asn Cys Cys Ala Glu Lys
          35                  40                  45            
 Ile Cys Thr Leu Pro Asn Arg Gly Leu Asp Arg Thr Lys Val Pro Ile
      50                  55                  60                
 Phe Leu Gly Ile Gln Gly Gly Ser Arg Cys Leu Ala Cys Val Glu Thr
  65                  70                  75                  80
 Glu Glu Gly Pro Ser Leu Gln Leu Glu Asp Val Asn Ile Glu Glu Leu
                  85                  90                  95    
 Tyr Lys Gly Gly Glu Glu Ala Thr Arg Phe Thr Phe Phe Gln Ser Ser
             100                 105                 110        
 Ser Gly Ser Ala Phe Arg Leu Glu Ala Ala Ala Trp Pro Gly Trp Phe
         115                 120                 125            
 Leu Cys Gly Pro Ala Glu Pro Gln Gln Pro Val Gln Leu Thr Lys Glu
     130                 135                 140                
 Ser Glu Pro Ser Ala Arg Thr Lys Phe Tyr Phe Glu Gln Ser Trp
 145                 150                 155                



      <210> 1164
      <211> 196
      <212> PRT
      <213> Homo sapiens


      <400> 1164
 Met Asn Phe Leu Leu Ser Trp Val His Trp Ser Leu Ala Leu Leu Leu
   1               5                  10                  15    
 Tyr Leu His His Ala Lys Trp Ser Gln Ala Ala Pro Met Ala Glu Gly
              20                  25                  30        
 Gly Gly Gln Asn His His Glu Val Val Lys Phe Met Asp Val Tyr Gln
          35                  40                  45            
 Arg Ser Tyr Cys His Pro Ile Glu Thr Leu Val Asp Ile Phe Gln Glu
      50                  55                  60                
 Tyr Pro Asp Glu Ile Glu Tyr Ile Phe Lys Pro Ser Cys Val Pro Leu
  65                  70                  75                  80
 Met Arg Cys Gly Gly Cys Cys Asn Asp Glu Gly Leu Glu Cys Val Pro
                  85                  90                  95    
 Thr Glu Glu Ser Asn Ile Thr Met Gln Ile Met Arg Ile Lys Pro His
             100                 105                 110        
 Gln Gly Gln His Ile Gly Glu Met Ser Phe Leu Gln His Asn Lys Cys
         115                 120                 125            
 Glu Cys Arg Pro Lys Lys Asp Arg Ala Arg Gln Glu Lys Lys Ser Val
     130                 135                 140                
 Arg Gly Lys Gly Lys Gly Gln Lys Arg Lys Arg Lys Lys Ser Arg Tyr
 145                 150                 155                 160
 Lys Ser Trp Ser Val Pro Cys Gly Pro Cys Ser Glu Arg Arg Lys His
                 165                 170                 175    
 Leu Phe Val Gln Asp Pro Gln Thr Cys Cys Ser Cys Ser Arg Cys Asp
             180                 185                 190        
 Lys Pro Arg Arg
         195    



      <210> 1165
      <211> 157
      <212> PRT
      <213> Homo sapiens


      <400> 1165
 Met Val Leu Ser Gly Ala Leu Cys Phe Arg Met Lys Asp Ser Ala Leu
   1               5                  10                  15    
 Lys Val Leu Tyr Leu His Asn Asn Gln Leu Leu Ala Gly Gly Leu His
              20                  25                  30        
 Ala Gly Lys Val Ile Lys Gly Glu Glu Ile Ser Val Val Pro Asn Arg
          35                  40                  45            
 Trp Leu Asp Ala Ser Leu Ser Pro Val Ile Leu Gly Val Gln Gly Gly
      50                  55                  60                
 Ser Gln Cys Leu Ser Cys Gly Val Gly Gln Glu Pro Thr Leu Thr Leu
  65                  70                  75                  80
 Glu Pro Val Asn Ile Met Glu Leu Tyr Leu Gly Ala Lys Glu Ser Lys
                  85                  90                  95    
 Ser Phe Thr Phe Tyr Arg Arg Asp Met Gly Leu Thr Ser Ser Phe Glu
             100                 105                 110        
 Ser Ala Ala Tyr Pro Gly Trp Phe Leu Cys Thr Val Pro Glu Ala Asp
         115                 120                 125            
 Gln Pro Val Arg Leu Thr Gln Leu Pro Glu Asn Gly Gly Trp Asn Ala
     130                 135                 140                
 Pro Met Thr Gly Thr Gly Phe His Pro Gly His Pro Gly
 145                 150                 155        



      <210> 1166
      <211> 134
      <212> PRT
      <213> Homo sapiens


      <400> 1166
 Met Leu Phe Cys Tyr Arg Phe Thr Leu His Thr Leu Phe Lys Ala His
   1               5                  10                  15    
 Met Gly Gln Lys His Trp Thr Met Trp Val Ile Phe Ala Val Val Leu
              20                  25                  30        
 Ile Phe Leu Leu Cys Trp Leu Pro Tyr Asn Leu Val Leu Leu Ala Asp
          35                  40                  45            
 Thr Leu Val Gly Thr Gln Met Thr Asn Glu Thr Cys Glu Arg Arg Asn
      50                  55                  60                
 Asp Ile Asn Gln Ala Leu Asp Ala Thr Glu Ile Leu Gly Ile Leu His
  65                  70                  75                  80
 Ser Tyr Leu Asn Pro Leu Ile Tyr Ala Phe Ile Gly Gln Lys Phe Cys
                  85                  90                  95    
 His Gly Leu Leu Lys Ile Ile Ala Ile His Gly Leu Ile Ser Lys Asp
             100                 105                 110        
 Ser Leu Pro Lys Asp Ser Arg Pro Ser Phe Val Gly Ser Ser Ser Gly
         115                 120                 125            
 His Thr Ser Thr Thr Leu
     130                



      <210> 1167
      <211> 282
      <212> PRT
      <213> Homo sapiens


      <400> 1167
 Met Ala Ser Pro Gly Cys Leu Trp Leu Leu Ala Val Ala Leu Leu Pro
   1               5                  10                  15    
 Trp Thr Cys Ala Ser Arg Ala Leu Gln His Leu Asp Pro Pro Ala Pro
              20                  25                  30        
 Leu Pro Leu Val Ile Trp His Gly Met Gly Asp Ser Cys Cys Asn Pro
          35                  40                  45            
 Leu Ser Met Gly Ala Ile Lys Lys Met Val Glu Lys Lys Ile Pro Gly
      50                  55                  60                
 Ile Tyr Val Leu Ser Leu Glu Ile Gly Lys Thr Leu Met Glu Asp Val
  65                  70                  75                  80
 Glu Asn Ser Phe Phe Leu Asn Val Asn Ser Gln Val Thr Thr Val Cys
                  85                  90                  95    
 Gln Ala Leu Ala Lys Asp Pro Lys Leu Gln Gln Gly Tyr Asn Ala Met
             100                 105                 110        
 Gly Phe Ser Gln Gly Gly Gln Phe Leu Arg Ala Val Ala Gln Arg Cys
         115                 120                 125            
 Pro Ser Pro Pro Met Ile Asn Leu Ile Ser Val Gly Gly Gln His Gln
     130                 135                 140                
 Gly Val Phe Gly Leu Pro Arg Cys Pro Gly Glu Ser Ser His Ile Cys
 145                 150                 155                 160
 Asp Phe Ile Arg Lys Thr Leu Asn Ala Gly Ala Tyr Ser Lys Val Val
                 165                 170                 175    
 Gln Glu Arg Leu Val Gln Ala Glu Tyr Trp His Asp Pro Ile Lys Glu
             180                 185                 190        
 Asp Val Tyr Arg Asn His Ser Ile Phe Leu Ala Asp Ile Asn Gln Glu
         195                 200                 205            
 Arg Gly Ile Asn Glu Ser Tyr Lys Lys Asn Leu Met Ala Leu Lys Lys
     210                 215                 220                
 Phe Val Met Val Lys Phe Leu Asn Asp Ser Ile Val Asp Pro Val Asp
 225                 230                 235                 240
 Ser Glu Asp Arg Leu Gly Leu Lys Glu Met Asp Asn Ala Gly Gln Leu
                 245                 250                 255    
 Val Phe Leu Ala Thr Glu Gly Asp His Leu Gln Leu Ser Glu Glu Trp
             260                 265                 270        
 Phe Tyr Ala His Ile Ile Pro Phe Leu Gly
         275                 280        



      <210> 1168
      <211> 418
      <212> PRT
      <213> Homo sapiens


      <400> 1168
 Met Pro Ser Ser Val Ser Trp Gly Ile Leu Leu Leu Ala Gly Leu Cys
   1               5                  10                  15    
 Cys Leu Val Pro Val Ser Leu Ala Glu Asp Pro Gln Gly Asp Ala Ala
              20                  25                  30        
 Gln Lys Thr Asp Thr Ser His His Asp Gln Asp His Pro Thr Phe Asn
          35                  40                  45            
 Lys Ile Thr Pro Asn Leu Ala Glu Phe Ala Phe Ser Leu Tyr Arg Gln
      50                  55                  60                
 Leu Ala His Gln Ser Asn Ser Thr Asn Ile Phe Phe Ser Pro Val Ser
  65                  70                  75                  80
 Ile Ala Thr Ala Phe Ala Met Leu Ser Leu Gly Thr Lys Ala Asp Thr
                  85                  90                  95    
 Arg Thr Glu Ile Leu Glu Gly Leu Asn Val Asn Leu Thr Glu Thr Pro
             100                 105                 110        
 Glu Ala Lys Ile His Glu Cys Phe Gln Gln Val Leu Gln Ala Leu Ser
         115                 120                 125            
 Arg Pro Asp Thr Arg Leu Gln Leu Thr Thr Gly Ser Ser Leu Phe Val
     130                 135                 140                
 Asn Lys Ser Met Lys Leu Val Asp Thr Phe Leu Glu Asp Thr Lys Lys
 145                 150                 155                 160
 Leu Tyr His Ser Glu Ala Ser Ser Ile Asn Phe Arg Asp Thr Glu Glu
                 165                 170                 175    
 Ala Lys Glu Gln Ile Asn Asn Tyr Val Glu Lys Arg Thr Gly Arg Lys
             180                 185                 190        
 Val Val Asp Leu Val Lys His Leu Lys Lys Asp Thr Ser Leu Ala Leu
         195                 200                 205            
 Val Asp Tyr Ile Ser Phe His Gly Lys Trp Lys Asp Lys Phe Lys Ala
     210                 215                 220                
 Glu Arg Ile Met Val Glu Gly Phe His Val Asp Asp Lys Thr Ile Ile
 225                 230                 235                 240
 Arg Val Pro Met Ile Asn His Leu Gly Arg Phe Asp Ile His Arg Asp
                 245                 250                 255    
 Arg Glu Leu Ser Ser Trp Val Leu Ala Gln His Tyr Val Gly Asn Ala
             260                 265                 270        
 Thr Ala Phe Phe Ile Leu Pro Asp Pro Lys Lys Met Trp Gln Leu Glu
         275                 280                 285            
 Glu Lys Leu Thr Tyr Ser His Leu Glu Asn Ile Gln Arg Ala Phe Asp
     290                 295                 300                
 Ile Arg Ser Ile Asn Leu His Phe Pro Lys Leu Ser Ile Ser Gly Thr
 305                 310                 315                 320
 Tyr Lys Leu Lys Arg Val Pro Arg Asn Leu Gly Ile Thr Lys Ile Phe
                 325                 330                 335    
 Ser Asn Glu Ala Asp Leu Ser Gly Val Ser Gln Glu Ala Pro Leu Lys
             340                 345                 350        
 Leu Ser Lys Ala Val His Val Ala Val Leu Thr Ile Asp Glu Lys Gly
         355                 360                 365            
 Thr Glu Ala Thr Gly Ala Pro His Leu Glu Glu Lys Ala Trp Ser Lys
     370                 375                 380                
 Tyr Gln Thr Val Met Phe Asn Arg Pro Phe Leu Val Ile Ile Lys Glu
 385                 390                 395                 400
 Tyr Ile Thr Asn Phe Pro Leu Phe Ile Gly Lys Val Val Asn Pro Thr
                 405                 410                 415    
 Gln Lys
        



      <210> 1169
      <211> 67
      <212> PRT
      <213> Homo sapiens


      <400> 1169
 Met Leu Cys Ile Ile Phe Pro Gln Gly Leu Phe Thr Arg Ala Leu Leu
   1               5                  10                  15    
 Arg Thr Cys Ser Ala Leu Leu His Ala Asp Trp Pro Glu Ile Ser Phe
              20                  25                  30        
 Val Val Val Val Val Phe Phe Lys Thr Glu Ser Cys Ser Val Ala Gln
          35                  40                  45            
 Asp Gly Val Gln Trp Cys Asp Leu Arg Ser Leu Lys Pro Pro Pro Pro
      50                  55                  60                
 Arg Phe Lys
  65        



      <210> 1170
      <211> 131
      <212> PRT
      <213> Homo sapiens


      <400> 1170
 Met Ala Ala Arg Met Ala Arg Val Leu Leu Ala Ile Glu Asp Leu Gly
   1               5                  10                  15    
 Gln Arg Thr Ala Val Cys Pro Leu Trp Ser Pro Cys Leu Ala Arg Gly
              20                  25                  30        
 Ser Val Thr Pro Ala Met Arg Thr Leu Ala Ile Leu Ala Ala Ile Leu
          35                  40                  45            
 Leu Val Ala Leu Gln Ala Gln Ala Glu Pro Leu Gln Ala Arg Ala Asp
      50                  55                  60                
 Glu Val Ala Ala Ala Pro Glu Gln Ile Ala Ala Asp Ile Pro Glu Val
  65                  70                  75                  80
 Val Val Ser Leu Ala Trp Asp Glu Ser Leu Ala Pro Lys His Pro Gly
                  85                  90                  95    
 Ser Arg Lys Asn Met Ala Cys Tyr Cys Arg Ile Pro Ala Cys Ile Ala
             100                 105                 110        
 Gly Glu Arg Arg Tyr Gly Thr Cys Ile Tyr Gln Gly Arg Leu Trp Ala
         115                 120                 125            
 Phe Cys Cys
     130    



      <210> 1171
      <211> 76
      <212> PRT
      <213> Homo sapiens


      <400> 1171
 Met Arg Leu Gly Lys Gly Asn Arg Ser Thr Ala Trp Ala Ser Ser Phe
   1               5                  10                  15    
 Arg Thr Gln Leu Pro Val Leu Leu Leu Ser Phe Leu Arg Phe Thr Leu
              20                  25                  30        
 Trp Val Gly Thr Ala Leu Ser Lys Ala Lys Val Ser Ala Lys Ser Glu
          35                  40                  45            
 Leu Ile Phe Tyr His Gln Val Leu Met Glu Thr Asp Cys Ile Ser Val
      50                  55                  60                
 Ile Cys Thr Ala Lys Thr Thr His Ser Phe Leu Ser
  65                  70                  75    



      <210> 1172
      <211> 508
      <212> PRT
      <213> Homo sapiens


      <400> 1172
 Met Pro Arg Pro Asp Leu Ala Pro Ala Leu Leu Val Ala Val Leu Val
   1               5                  10                  15    
 Leu Leu Tyr Leu Leu Val Ser Ala Ala Ala Pro Ala Pro Ser Ser Asp
              20                  25                  30        
 Ser Thr Pro Glu Asn Val Cys Pro Val Glu Thr Thr Thr Asn Phe Ile
          35                  40                  45            
 Trp Glu Leu Ser Ser Pro His Asn Thr Ser Ala Val Leu Leu Val Val
      50                  55                  60                
 Phe His Lys Gly Pro Ser Cys Arg Asn Ser Gly Phe Lys Pro Leu Asn
  65                  70                  75                  80
 Asp Glu Lys Ala Arg Ser Val Phe Tyr Leu Ile Ser Phe Ser Pro Arg
                  85                  90                  95    
 Leu Cys Ser Val Asn Asp Tyr Glu Gly Asn Asp Ser Glu Ala Glu Asp
             100                 105                 110        
 Leu Asn Phe Arg Glu Ala Leu Pro Ser Ser Ser Gln Glu Asn Thr Pro
         115                 120                 125            
 Arg Ser Lys Val Phe Glu Asn Lys Val Asn Ser Glu Lys Val Lys Leu
     130                 135                 140                
 Ser Leu Arg Asn Phe Pro His Asn Asp Tyr Glu Asp Val Phe Glu Glu
 145                 150                 155                 160
 Pro Ser Glu Ser Gly Ser Asp Pro Ser Met Trp Thr Ala Arg Gly Pro
                 165                 170                 175    
 Phe Arg Arg Asp Arg Trp Ser Ser Glu Asp Glu Glu Ala Ala Gly Pro
             180                 185                 190        
 Ser Gln Ala Leu Ser Pro Leu Leu Ser Asp Thr Arg Lys Ile Val Ser
         195                 200                 205            
 Glu Gly Glu Leu Asp Gln Leu Ala Gln Ile Arg Pro Leu Ile Phe Asn
     210                 215                 220                
 Phe His Glu Gln Thr Ala Ile Lys Asp Cys Leu Lys Ile Leu Glu Glu
 225                 230                 235                 240
 Lys Thr Ala Ala Tyr Asp Ile Met Gln Glu Phe Met Ala Leu Glu Leu
                 245                 250                 255    
 Lys Asn Leu Pro Gly Glu Phe Tyr Ser Gly Asn Gln Pro Ser Asn Arg
             260                 265                 270        
 Glu Lys Asn Arg Tyr Arg Asp Ile Leu Pro Tyr Asp Ser Thr Arg Val
         275                 280                 285            
 Pro Leu Gly Lys Ser Lys Asp Tyr Ile Asn Ala Ser Tyr Ile Arg Ile
     290                 295                 300                
 Val Asn Cys Gly Glu Glu Tyr Phe Tyr Ile Ala Thr Gln Gly Pro Leu
 305                 310                 315                 320
 Leu Ser Thr Ile Asp Asp Phe Trp Gln Met Val Leu Glu Asn Asn Ser
                 325                 330                 335    
 Asn Val Ile Ala Met Ile Thr Arg Glu Met Glu Gly Gly Ile Ile Lys
             340                 345                 350        
 Cys Tyr His Tyr Trp Pro Ile Ser Leu Lys Lys Pro Leu Glu Leu Lys
         355                 360                 365            
 His Phe Arg Val Phe Leu Glu Asn Tyr Gln Ile Leu Gln Tyr Phe Ile
     370                 375                 380                
 Ile Arg Met Phe Gln Val Val Glu Lys Ser Thr Gly Thr Ser His Ser
 385                 390                 395                 400
 Val Lys Gln Leu Gln Phe Thr Lys Trp Pro Asp His Gly Thr Pro Ala
                 405                 410                 415    
 Ser Ala Asp Ser Phe Ile Lys Tyr Ile Arg Tyr Ala Arg Lys Ser His
             420                 425                 430        
 Leu Thr Gly Pro Met Val Val His Cys Ser Ala Gly Ile Gly Arg Thr
         435                 440                 445            
 Gly Val Phe Leu Cys Val Asp Val Val Phe Cys Ala Ile Val Lys Asp
     450                 455                 460                
 Cys Ser Phe Asn Ile Met Asp Ile Val Ala Gln Met Arg Glu Gln Arg
 465                 470                 475                 480
 Ser Gly Met Val Gln Thr Lys Glu Gln Tyr His Phe Cys Tyr Asp Ile
                 485                 490                 495    
 Val Leu Glu Val Leu Arg Lys Leu Leu Thr Leu Asp
             500                 505            



      <210> 1173
      <211> 194
      <212> PRT
      <213> Homo sapiens


      <400> 1173
 Met Glu Glu Gly Gly Asn Leu Gly Gly Leu Ile Lys Met Val His Leu
   1               5                  10                  15    
 Leu Val Leu Ser Gly Ala Trp Gly Met Gln Met Trp Val Thr Phe Val
              20                  25                  30        
 Ser Gly Phe Leu Leu Phe Arg Ser Leu Pro Arg His Thr Phe Gly Leu
          35                  40                  45            
 Val Gln Ser Lys Leu Phe Pro Phe Tyr Phe His Ile Ser Met Gly Cys
      50                  55                  60                
 Ala Phe Ile Asn Leu Cys Ile Leu Ala Ser Gln His Ala Trp Ala Gln
  65                  70                  75                  80
 Leu Thr Phe Trp Glu Ala Ser Gln Leu Tyr Leu Leu Phe Leu Ser Leu
                  85                  90                  95    
 Thr Leu Ala Thr Val Asn Ala Arg Trp Leu Glu Pro Arg Thr Thr Ala
             100                 105                 110        
 Ala Met Trp Ala Leu Gln Thr Val Glu Lys Glu Arg Gly Leu Gly Gly
         115                 120                 125            
 Glu Val Pro Gly Ser His Gln Gly Pro Asp Pro Tyr Arg Gln Leu Arg
     130                 135                 140                
 Glu Lys Asp Pro Lys Tyr Ser Ala Leu Arg Thr Glu Phe Leu Pro Leu
 145                 150                 155                 160
 His Gly Leu Ser Ser Leu Cys Asn Leu Gly Cys Val Leu Ser Asn Gly
                 165                 170                 175    
 Leu Cys Leu Ala Gly Leu Pro Trp Glu Leu Gly Ala Leu Ala Gly Pro
             180                 185                 190        
 Gly Val
        



      <210> 1174
      <211> 52
      <212> PRT
      <213> Homo sapiens


      <400> 1174
 Met Lys Leu Cys Val Thr Val Leu Ser Leu Leu Met Leu Val Ala Ala
   1               5                  10                  15    
 Phe Cys Ser Pro Ala Leu Ser Ala Pro Asn Ser Lys Pro Lys Glu Ala
              20                  25                  30        
 Ser Lys Ser Val Leu Ile Pro Val Asn Pro Gly Ser Arg Ser Thr Cys
          35                  40                  45            
 Met Thr Trp Asn
      50        



      <210> 1175
      <211> 61
      <212> PRT
      <213> Homo sapiens


      <400> 1175
 Met Lys Leu Cys Val Thr Val Leu Ser Leu Leu Met Leu Val Ala Ala
   1               5                  10                  15    
 Phe Cys Ser Pro Ala Leu Ser Ala Pro Ser Lys Ser Thr Phe Ala Ala
              20                  25                  30        
 Ala Ile Ser Ser Gln Gly Val Gly Arg Val Leu Phe Ser Ser His Gly
          35                  40                  45            
 Trp Gln Thr Val Gly Ser Gly Asp Gly Thr Lys Gly Ser
      50                  55                  60    



      <210> 1176
      <211> 81
      <212> PRT
      <213> Homo sapiens


      <400> 1176
 Met Leu Leu Arg Thr Leu Pro Tyr Thr Lys Asn Met Lys Ile Phe Phe
   1               5                  10                  15    
 His Ile Phe Phe His Lys Cys Leu Phe Thr Tyr Arg Leu Phe Ile Thr
              20                  25                  30        
 Leu Ala Leu Ile Leu Trp Tyr Ser Asp Ile Glu Glu Ser Thr Phe Pro
          35                  40                  45            
 Pro Leu Met Arg Tyr Cys Pro Asn Thr Val Leu His Lys Ser Phe Phe
      50                  55                  60                
 Gln Met Ser Ala Phe Ile Thr Tyr Gln Phe Ser Leu Tyr Leu Ser Leu
  65                  70                  75                  80
 Phe
    



      <210> 1177
      <211> 101
      <212> PRT
      <213> Homo sapiens


      <400> 1177
 Met Gly Thr Arg Leu Leu Thr Thr Leu Leu Leu Val Leu Leu Glu Leu
   1               5                  10                  15    
 Gly Phe Glu Val Gln Gly Thr Gln Gln Pro His His Asp Asp Met Pro
              20                  25                  30        
 Ser Pro Thr Phe Leu Thr Gln Val Gln Glu Ser Ile Ser Arg Tyr Trp
          35                  40                  45            
 Glu Ser Ala Lys Thr Ala Ala Gln Asn Leu Tyr Glu Lys Thr Tyr Leu
      50                  55                  60                
 Pro Ala Val Asn Glu Lys Leu Arg Asp Leu Tyr Ser Lys Ser Thr Ala
  65                  70                  75                  80
 Ala Met Ser Thr Tyr Thr Gly Ile Phe Thr Asp Gln Val Leu Ser Val
                  85                  90                  95    
 Leu Lys Gly Glu Glu
             100    



      <210> 1178
      <211> 114
      <212> PRT
      <213> Homo sapiens


      <400> 1178
 Met Ser Cys Leu Leu Ile Phe Phe Thr Ala Gln Pro Gly Ile Gly Val
   1               5                  10                  15    
 Gly Asp Ser Asp Gly Gln Leu Gly Ser Ser Phe His Asp Gly Phe Ala
              20                  25                  30        
 Val Leu Gly Gly Asn Ile Val Ser Asp Leu Gly Thr Val Arg Phe Val
          35                  40                  45            
 Ala His Gln Gln His Phe Gln Leu Leu Asp Val Val Asp Gln Glu Leu
      50                  55                  60                
 Pro Glu Ala Thr Gly Gln His Val Leu Cys Phe Phe Val Ala Ser Ile
  65                  70                  75                  80
 Thr Asn Val Gly His Gln Asp Leu Ala Leu Glu Ser Ser Thr Asn Pro
                  85                  90                  95    
 Val Val Asn Ala Ser Gly Phe Pro Pro Val Thr Leu Asn Phe Asp Ile
             100                 105                 110        
 Ser Val
        



      <210> 1179
      <211> 316
      <212> PRT
      <213> Homo sapiens


      <400> 1179
 Met Ala Met Ile Glu Leu Gly Phe Gly Arg Gln Asn Phe His Pro Leu
   1               5                  10                  15    
 Lys Arg Lys Ser Ser Leu Leu Leu Lys Leu Ile Ala Val Val Phe Ala
              20                  25                  30        
 Val Leu Leu Phe Cys Glu Phe Leu Ile Tyr Tyr Leu Ala Ile Phe Gln
          35                  40                  45            
 Cys Asn Trp Pro Glu Val Lys Thr Thr Ala Ser Asp Gly Glu Gln Thr
      50                  55                  60                
 Thr Arg Glu Pro Val Leu Lys Ala Met Phe Leu Ala Asp Thr His Leu
  65                  70                  75                  80
 Leu Gly Glu Phe Leu Gly His Trp Leu Asp Lys Leu Arg Arg Glu Trp
                  85                  90                  95    
 Gln Met Glu Arg Ala Phe Gln Thr Ala Leu Trp Leu Leu Gln Pro Glu
             100                 105                 110        
 Val Val Phe Ile Leu Gly Asp Ile Phe Asp Glu Gly Lys Trp Ser Thr
         115                 120                 125            
 Pro Glu Ala Trp Ala Asp Asp Val Glu Arg Phe Gln Lys Met Phe Arg
     130                 135                 140                
 His Pro Ser His Val Gln Leu Lys Val Val Ala Gly Asn His Asp Ile
 145                 150                 155                 160
 Gly Phe His Tyr Glu Met Asn Thr Tyr Lys Val Glu Arg Phe Glu Lys
                 165                 170                 175    
 Val Phe Ser Ser Glu Arg Leu Phe Ser Trp Lys Gly Ile Asn Phe Val
             180                 185                 190        
 Met Val Asn Ser Val Ala Leu Asn Gly Asp Gly Cys Gly Ile Cys Ser
         195                 200                 205            
 Glu Thr Glu Ala Glu Leu Ile Glu Val Ser His Arg Leu Asn Cys Ser
     210                 215                 220                
 Arg Glu His Tyr Pro Leu Tyr Gln Arg Ser Asp Ala Asn Cys Ser Gly
 225                 230                 235                 240
 Glu Asp Ala Ala Pro Pro Glu Glu Arg Asp Ile Pro Phe Lys Glu Asn
                 245                 250                 255    
 Tyr Asp Val Leu Ser Arg Glu Ala Ser Gln Lys Leu Leu Trp Trp Leu
             260                 265                 270        
 Gln Pro Arg Leu Val Leu Ser Gly His Thr His Ser Ala Cys Glu Val
         275                 280                 285            
 His His Gly Gly Arg Val Pro Glu Leu Ser Val Pro Ser Phe Ser Trp
     290                 295                 300                
 Arg Asn Arg Asn Asn Pro Ser Phe Ile Met Val Pro
 305                 310                 315    



      <210> 1180
      <211> 81
      <212> PRT
      <213> Homo sapiens


      <400> 1180
 Met Leu Tyr Pro Arg Ile Phe Thr Asn Arg Gly Glu Leu Leu Pro Phe
   1               5                  10                  15    
 Leu Phe Leu Thr Val Trp Leu Trp Leu Tyr Lys Leu Leu Phe Gly Glu
              20                  25                  30        
 Ser Pro Arg Tyr Pro Asn Val Ile Gly Lys Thr Tyr Phe Phe Phe Trp
          35                  40                  45            
 Thr Asp Gln Ile Ser Arg Glu Ser Arg Phe Leu Glu Arg Leu Ala Phe
      50                  55                  60                
 Ile Val Ser Glu Asn Cys Leu Ile Phe Leu Ile His Ala Ile Thr Gly
  65                  70                  75                  80
 Gln
    



      <210> 1181
      <211> 80
      <212> PRT
      <213> Homo sapiens


      <400> 1181
 Met Tyr Thr Gly His Glu Asn Lys Asp Trp Phe Ser Ser Arg His Trp
   1               5                  10                  15    
 Phe Thr Leu Gln Pro Val Phe Ser Val Ser Pro Phe Pro Thr Ser Phe
              20                  25                  30        
 Pro Pro Pro Asn Pro Phe Phe Phe Leu Phe Cys Phe Ser Phe Leu Phe
          35                  40                  45            
 Phe Ser Phe Tyr Leu Leu Tyr Leu Val Cys Leu Phe Leu Val Ala Ser
      50                  55                  60                
 Gln Val Lys Lys Leu Phe Arg Lys Val Ser Leu Cys Ile Cys Thr Lys
  65                  70                  75                  80





      <210> 1182
      <211> 101
      <212> PRT
      <213> Homo sapiens


      <400> 1182
 Met Ser Glu Glu Thr Leu Gln Ser Lys Leu Ala Ala Ala Lys Lys Lys
   1               5                  10                  15    
 Leu Pro Trp Gly Ala Val Gln Gly Ser Arg Ala Met Ser Asp Leu Leu
              20                  25                  30        
 Leu Leu Leu Leu Asp Leu Thr Leu Leu Leu Leu Leu Met Leu Leu Gly
          35                  40                  45            
 Phe Ala Gly Tyr Ser Gly Gln Leu Ala Gly Val Ala Val Ser Ala Gly
      50                  55                  60                
 Ser Pro Pro Ile Pro Thr Ser Ser Met Trp Ser Pro Met Val Arg Leu
  65                  70                  75                  80
 Gly Gly Phe Ser Pro Glu Leu Gln His Leu Pro Gln Thr Leu Leu His
                  85                  90                  95    
 Arg Cys Pro Leu Gly
             100    



      <210> 1183
      <211> 165
      <212> PRT
      <213> Homo sapiens


      <400> 1183
 Met Ala Thr Pro Leu Pro Pro Pro Ser Pro Arg His Leu Arg Leu Leu
   1               5                  10                  15    
 Arg Leu Pro Leu Ser Gly Leu Ala Leu Val Leu Ile Leu Ala Phe Cys
              20                  25                  30        
 Val Ala Gly Ala Ala Ala Leu Ser Val Ala Ser Leu Cys Trp Cys Arg
          35                  40                  45            
 Leu Gln Arg Glu Ile Arg Leu Thr Gln Lys Ala Asp Tyr Ala Thr Ala
      50                  55                  60                
 Lys Ala Pro Gly Ser Pro Ala Ala Pro Arg Ile Ser Pro Gly Asp Gln
  65                  70                  75                  80
 Arg Leu Ala Gln Ser Ala Glu Met Tyr His Tyr Gln His Gln Arg Gln
                  85                  90                  95    
 Gln Met Leu Cys Leu Glu Trp His Lys Glu Pro Pro Lys Glu Met Asp
             100                 105                 110        
 Thr Ala Ser Ser Asp Glu Glu Asn Glu Asp Gly Asp Phe Thr Val Tyr
         115                 120                 125            
 Glu Cys Pro Gly Leu Ala Pro Thr Gly Glu Met Glu Val Arg Asn Pro
     130                 135                 140                
 Leu Phe Asp His Ala Ala Leu Ser Ala Pro Leu Pro Ala Pro Ser Ser
 145                 150                 155                 160
 Pro Pro Ala Leu Pro
                 165



      <210> 1184
      <211> 213
      <212> PRT
      <213> Homo sapiens


      <400> 1184
 Met Ala Ala Ala Ala Ser Pro Ala Phe Leu Leu Arg Leu Pro Leu Leu
   1               5                  10                  15    
 Leu Leu Leu Ser Ser Trp Cys Arg Thr Gly Leu Ala Asp Pro His Ser
              20                  25                  30        
 Leu Cys Tyr Asp Ile Thr Val Ile Pro Lys Phe Arg Pro Gly Pro Arg
          35                  40                  45            
 Trp Cys Ala Val Gln Gly Gln Val Asp Glu Lys Thr Phe Leu His Tyr
      50                  55                  60                
 Asp Cys Gly Ser Lys Thr Val Thr Pro Val Ser Pro Leu Gly Lys Lys
  65                  70                  75                  80
 Leu Asn Val Thr Thr Ala Trp Lys Ala Gln Asn Pro Val Leu Arg Glu
                  85                  90                  95    
 Val Val Asp Ile Leu Thr Glu Gln Leu Leu Asp Ile Gln Leu Glu Asn
             100                 105                 110        
 Tyr Ile Pro Lys Glu Pro Leu Thr Leu Gln Ala Arg Met Ser Cys Glu
         115                 120                 125            
 Gln Lys Ala Glu Gly His Gly Ser Gly Ser Trp Gln Leu Ser Phe Asp
     130                 135                 140                
 Gly Gln Ile Phe Leu Leu Phe Asp Ser Glu Asn Arg Met Trp Thr Thr
 145                 150                 155                 160
 Val His Pro Gly Ala Arg Lys Met Lys Glu Lys Trp Glu Asn Asp Lys
                 165                 170                 175    
 Asp Met Thr Met Ser Phe His Tyr Ile Ser Met Gly Asp Cys Thr Gly
             180                 185                 190        
 Trp Leu Glu Asp Phe Leu Met Gly Met Asp Ser Thr Leu Glu Pro Ser
         195                 200                 205            
 Ala Gly Ala Thr Lys
     210            



      <210> 1185
      <211> 109
      <212> PRT
      <213> Homo sapiens


      <400> 1185
 Met Arg Ser Met Pro Gly Asn Cys Leu Pro Leu Trp Pro His Leu Leu
   1               5                  10                  15    
 Ala Arg Pro Pro Arg Glu Leu Trp Pro Asp Val Met Gly Leu Pro Met
              20                  25                  30        
 Val Ala Ser Val Leu Cys Phe Ser Gly Phe Trp Ala Phe Ala His Ala
          35                  40                  45            
 Ile Leu Pro Ala Arg Ser Ala Leu Leu Ser Ser Pro Pro Thr Ser Val
      50                  55                  60                
 Pro Leu Thr Ser Leu Leu Arg Gln Lys Ser Ile Ser Gly Ser Phe Pro
  65                  70                  75                  80
 Arg Ala Pro Lys Leu Ala Leu Met Val Leu Leu Pro Pro Thr Leu Gly
                  85                  90                  95    
 Leu Leu Tyr Ser Thr His Leu Leu His Arg His Cys Leu
             100                 105                



      <210> 1186
      <211> 114
      <212> PRT
      <213> Homo sapiens


      <400> 1186
 Met Arg Ser Gln Pro Arg Glu His Leu Phe Phe Thr Phe Leu Leu Lys
   1               5                  10                  15    
 Ile His Trp Gly Gly Ile Lys Phe Thr Pro Lys Lys Phe Ala Trp Ala
              20                  25                  30        
 Lys Ser Leu Gln Val Pro Ser Glu Asn Lys Ile Leu Met Ile Phe Phe
          35                  40                  45            
 Phe Phe Gly Cys Leu Gly Glu Thr Phe Ser Ile Leu Ser Arg Tyr Pro
      50                  55                  60                
 Asp Met Ser Leu Gln His Thr His Ser Thr Phe Ser Ser Gly Ser Phe
  65                  70                  75                  80
 His Pro Pro Glu Arg Thr Val Leu Ser His Ser Tyr Ser Ile Ser Lys
                  85                  90                  95    
 Ser Tyr Ser Val Ser Thr Thr Ala Ala Leu Pro Arg Lys Gly Lys Met
             100                 105                 110        
 Lys Gly
        



      <210> 1187
      <211> 849
      <212> PRT
      <213> Homo sapiens


      <400> 1187
 Met Leu Trp Ala Leu Trp Pro Arg Trp Leu Ala Asp Lys Met Leu Pro
   1               5                  10                  15    
 Leu Leu Gly Ala Val Leu Leu Gln Lys Arg Glu Lys Arg Gly Pro Leu
              20                  25                  30        
 Trp Arg His Trp Arg Arg Glu Thr Tyr Pro Tyr Tyr Asp Leu Gln Val
          35                  40                  45            
 Lys Val Leu Arg Ala Thr Asn Ile Arg Gly Thr Asp Leu Leu Ser Lys
      50                  55                  60                
 Ala Asp Cys Tyr Val Gln Leu Trp Leu Pro Thr Ala Ser Pro Ser Pro
  65                  70                  75                  80
 Ala Gln Thr Arg Ile Val Ala Asn Cys Ser Asp Pro Glu Trp Asn Glu
                  85                  90                  95    
 Thr Phe His Tyr Gln Ile His Gly Ala Val Lys Asn Val Leu Glu Leu
             100                 105                 110        
 Thr Leu Tyr Asp Lys Asp Ile Leu Gly Ser Asp Gln Leu Ser Leu Leu
         115                 120                 125            
 Leu Phe Asp Leu Arg Ser Leu Lys Cys Gly Gln Pro His Lys His Thr
     130                 135                 140                
 Phe Pro Leu Asn His Gln Asp Ser Gln Glu Leu Gln Val Glu Phe Val
 145                 150                 155                 160
 Leu Glu Lys Ser Gln Val Pro Ala Ser Glu Val Ile Thr Asn Gly Val
                 165                 170                 175    
 Leu Val Ala His Pro Cys Leu Arg Ile Gln Gly Thr Leu Arg Gly Asp
             180                 185                 190        
 Gly Thr Ala Pro Arg Glu Glu Tyr Gly Ser Arg Gln Leu Gln Leu Ala
         195                 200                 205            
 Val Pro Gly Ala Tyr Glu Lys Pro Gln Leu Leu Pro Leu Gln Pro Pro
     210                 215                 220                
 Thr Glu Pro Gly Leu Pro Pro Thr Phe Thr Phe His Val Asn Pro Val
 225                 230                 235                 240
 Leu Ser Ser Arg Leu His Val Glu Leu Met Glu Leu Leu Ala Ala Val
                 245                 250                 255    
 Gln Ser Gly Pro Ser Ala Glu Leu Glu Ala Gln Thr Ser Lys Leu Gly
             260                 265                 270        
 Glu Gly Gly Ile Leu Leu Ser Ser Leu Pro Leu Gly Gln Glu Glu Gln
         275                 280                 285            
 Cys Ser Val Ala Leu Gly Glu Gly Gln Glu Val Ala Leu Ser Met Lys
     290                 295                 300                
 Val Glu Met Ser Ser Gly Asp Leu Asp Leu Arg Leu Gly Phe Asp Leu
 305                 310                 315                 320
 Ser Asp Gly Glu Gln Glu Phe Leu Asp Arg Arg Lys Gln Val Val Ser
                 325                 330                 335    
 Lys Ala Leu Gln Gln Val Leu Gly Leu Ser Glu Ala Leu Asp Ser Gly
             340                 345                 350        
 Gln Val Pro Val Val Ala Val Leu Gly Ser Gly Gly Gly Thr Arg Ala
         355                 360                 365            
 Met Ser Ser Leu Tyr Gly Ser Leu Ala Gly Leu Gln Glu Leu Gly Leu
     370                 375                 380                
 Leu Asp Thr Val Thr Tyr Leu Ser Gly Val Ser Gly Ser Thr Trp Cys
 385                 390                 395                 400
 Ile Ser Thr Leu Tyr Arg Asp Pro Ala Trp Ser Gln Val Ala Leu Gln
                 405                 410                 415    
 Gly Pro Ile Glu Arg Ala Gln Val His Val Cys Ser Ser Lys Met Gly
             420                 425                 430        
 Ala Leu Ser Thr Glu Arg Leu Gln Tyr Tyr Thr Gln Glu Leu Gly Val
         435                 440                 445            
 Arg Glu Arg Ser Gly His Ser Val Ser Leu Ile Asp Leu Trp Gly Leu
     450                 455                 460                
 Leu Val Glu Tyr Leu Leu Tyr Gln Glu Glu Asn Pro Ala Lys Leu Ser
 465                 470                 475                 480
 Asp Gln Gln Glu Ala Val Arg Gln Gly Gln Asn Pro Tyr Pro Ile Tyr
                 485                 490                 495    
 Thr Ser Val Asn Val Arg Thr Asn Leu Ser Gly Glu Asp Phe Ala Glu
             500                 505                 510        
 Trp Cys Glu Phe Thr Pro Tyr Glu Val Gly Phe Pro Lys Tyr Gly Ala
         515                 520                 525            
 Tyr Val Pro Thr Glu Leu Phe Gly Ser Glu Leu Phe Met Gly Arg Leu
     530                 535                 540                
 Leu Gln Leu Gln Pro Glu Pro Arg Ile Cys Tyr Leu Gln Gly Met Trp
 545                 550                 555                 560
 Gly Ser Ala Phe Ala Thr Ser Leu Asp Glu Ile Phe Leu Lys Thr Ala
                 565                 570                 575    
 Gly Ser Gly Leu Ser Phe Leu Glu Trp Tyr Arg Gly Ser Val Asn Ile
             580                 585                 590        
 Thr Asp Asp Cys Gln Lys Pro Gln Leu His Asn Pro Ser Arg Leu Arg
         595                 600                 605            
 Thr Arg Leu Leu Thr Pro Gln Gly Pro Phe Ser Gln Ala Val Leu Asp
     610                 615                 620                
 Ile Phe Thr Ser Arg Phe Thr Ser Ala Gln Ser Phe Asn Phe Thr Arg
 625                 630                 635                 640
 Gly Leu Cys Leu His Lys Asp Tyr Val Ala Gly Arg Glu Phe Val Ala
                 645                 650                 655    
 Trp Lys Asp Thr His Pro Asp Ala Phe Pro Asn Gln Leu Thr Pro Met
             660                 665                 670        
 Arg Asp Cys Leu Tyr Leu Val Asp Gly Gly Phe Ala Ile Asn Ser Pro
         675                 680                 685            
 Phe Pro Leu Ala Leu Leu Pro Gln Arg Ala Val Asp Leu Ile Leu Ser
     690                 695                 700                
 Phe Asp Tyr Ser Leu Glu Ala Pro Phe Glu Val Leu Lys Met Thr Glu
 705                 710                 715                 720
 Lys Tyr Cys Leu Asp Arg Gly Ile Pro Phe Pro Ser Ile Glu Val Gly
                 725                 730                 735    
 Pro Glu Asp Val Glu Glu Ala Arg Glu Cys Tyr Leu Phe Ala Lys Ala
             740                 745                 750        
 Glu Asp Pro Arg Ser Pro Ile Val Leu His Phe Pro Leu Val Asn Arg
         755                 760                 765            
 Thr Phe Arg Thr His Leu Ala Pro Gly Val Glu Arg Gln Thr Ala Glu
     770                 775                 780                
 Glu Lys Ala Phe Gly Asp Phe Val Ile Asn Arg Pro Asp Thr Pro Tyr
 785                 790                 795                 800
 Gly Met Met Asn Phe Thr Tyr Glu Pro Gln Asp Phe Tyr Arg Leu Val
                 805                 810                 815    
 Ala Leu Ser Arg Tyr Asn Val Leu Asn Asn Val Glu Thr Leu Lys Cys
             820                 825                 830        
 Ala Leu Gln Leu Ala Leu Asp Arg His Gln Ala Arg Glu Arg Ala Gly
         835                 840                 845            
 Ala
    



      <210> 1188
      <211> 122
      <212> PRT
      <213> Homo sapiens


      <400> 1188
 Met Pro Gly Ser Cys Cys Ser Leu Cys Pro Thr Tyr Leu His Ala Arg
   1               5                  10                  15    
 Leu Leu Leu Gln Pro Leu Pro His Leu Pro Pro Arg Leu Phe Leu Leu
              20                  25                  30        
 Gln Pro Leu Pro His Leu Pro Pro Cys Pro Ala Pro Ala Ala Ala Ser
          35                  40                  45            
 Ala Pro Ser Thr Ser Thr Arg Ser Ser Cys Cys Ser Leu Cys Pro Ile
      50                  55                  60                
 Tyr Leu His Ala Cys Ser Cys Cys Ser Leu Cys Pro Ile Tyr Leu His
  65                  70                  75                  80
 Ala Arg Leu Leu Leu Gln Pro Leu Pro His Leu Pro Pro Arg Pro Ala
                  85                  90                  95    
 Pro Ala Ala Ala Ser Ala Pro Ser Thr Ala Thr Pro Gly Ser Cys Cys
             100                 105                 110        
 Ser Leu Cys Pro Ile Tyr Cys Tyr Ala Trp
         115                 120        



      <210> 1189
      <211> 334
      <212> PRT
      <213> Homo sapiens


      <400> 1189
 Met Arg Ser Leu Gly Ala Leu Leu Leu Leu Leu Ser Ala Cys Leu Ala
   1               5                  10                  15    
 Val Ser Ala Gly Pro Val Pro Thr Pro Pro Asp Asn Ile Gln Val Gln
              20                  25                  30        
 Glu Asn Phe Asn Ile Ser Arg Ile Tyr Gly Lys Trp Tyr Asn Leu Ala
          35                  40                  45            
 Ile Gly Ser Thr Cys Pro Trp Leu Lys Lys Ile Met Asp Arg Met Thr
      50                  55                  60                
 Val Ser Thr Leu Val Leu Gly Glu Gly Ala Thr Glu Ala Glu Ile Ser
  65                  70                  75                  80
 Met Thr Ser Thr Arg Trp Arg Lys Gly Val Cys Glu Glu Thr Ser Gly
                  85                  90                  95    
 Ala Tyr Glu Lys Thr Asp Thr Asp Gly Lys Phe Leu Tyr His Lys Ser
             100                 105                 110        
 Lys Trp Asn Ile Thr Met Glu Ser Tyr Val Val His Thr Asn Tyr Asp
         115                 120                 125            
 Glu Tyr Ala Ile Phe Leu Thr Lys Lys Phe Ser Arg His His Gly Pro
     130                 135                 140                
 Thr Ile Thr Ala Lys Leu Tyr Gly Arg Ala Pro Gln Leu Arg Glu Thr
 145                 150                 155                 160
 Leu Leu Gln Asp Phe Arg Val Val Ala Gln Gly Val Gly Ile Pro Glu
                 165                 170                 175    
 Asp Ser Ile Phe Thr Met Ala Asp Arg Gly Glu Cys Val Pro Gly Glu
             180                 185                 190        
 Gln Glu Pro Glu Pro Ile Leu Ile Pro Arg Val Arg Arg Ala Val Leu
         195                 200                 205            
 Pro Gln Glu Glu Glu Gly Ser Gly Gly Gly Gln Leu Val Thr Glu Val
     210                 215                 220                
 Thr Lys Lys Glu Asp Ser Cys Gln Leu Gly Tyr Ser Ala Gly Pro Cys
 225                 230                 235                 240
 Met Gly Met Thr Ser Arg Tyr Phe Tyr Asn Gly Thr Ser Met Ala Cys
                 245                 250                 255    
 Glu Thr Phe Gln Tyr Gly Gly Cys Met Gly Asn Gly Asn Asn Phe Val
             260                 265                 270        
 Thr Val Arg Gly Pro Cys Arg Ala Phe Ile Gln Leu Trp Ala Phe Asp
         275                 280                 285            
 Ala Val Lys Gly Lys Cys Val Leu Phe Pro Tyr Gly Gly Cys Gln Gly
     290                 295                 300                
 Asn Gly Asn Lys Phe Tyr Ser Glu Lys Glu Cys Arg Glu Tyr Cys Gly
 305                 310                 315                 320
 Val Pro Gly Asp Gly Asp Glu Glu Leu Leu Arg Phe Ser Asn
                 325                 330                



      <210> 1190
      <211> 281
      <212> PRT
      <213> Homo sapiens


      <400> 1190
 Met Asn Met Leu Thr Ala Ser Leu Leu Arg Ala Val Ile Ala Ser Ile
   1               5                  10                  15    
 Cys Val Val Ser Ser Met Ala Gln Lys Val Thr Gln Ala Gln Thr Glu
              20                  25                  30        
 Ile Ser Val Val Glu Lys Glu Asp Val Thr Leu Asp Cys Val Tyr Glu
          35                  40                  45            
 Thr Arg Asp Thr Thr Tyr Tyr Leu Phe Trp Tyr Lys Gln Pro Pro Ser
      50                  55                  60                
 Gly Glu Leu Val Phe Leu Ile Arg Arg Asn Ser Phe Asp Glu Gln Asn
  65                  70                  75                  80
 Glu Ile Ser Gly Arg Tyr Ser Trp Asn Phe Gln Lys Ser Thr Ser Ser
                  85                  90                  95    
 Phe Asn Phe Thr Ile Thr Ala Ser Gln Val Val Asp Ser Ala Val Tyr
             100                 105                 110        
 Phe Cys Ala Leu Ser Glu Ala Ala Gln Glu Thr Ser Gly Ser Arg Leu
         115                 120                 125            
 Thr Phe Gly Glu Gly Thr Gln Leu Thr Val Asn Pro Asp Ile Gln Asn
     130                 135                 140                
 Pro Asp Pro Ala Val Tyr Gln Leu Arg Asp Ser Lys Ser Ser Asp Lys
 145                 150                 155                 160
 Ser Val Cys Leu Phe Thr Asp Phe Asp Ser Gln Thr Asn Val Ser Gln
                 165                 170                 175    
 Ser Lys Asp Ser Asp Val Tyr Ile Thr Asp Lys Thr Val Leu Asp Met
             180                 185                 190        
 Arg Ser Met Asp Phe Lys Ser Asn Ser Ala Val Ala Trp Ser Asn Lys
         195                 200                 205            
 Ser Asp Phe Ala Cys Ala Asn Ala Phe Asn Asn Ser Ile Ile Pro Glu
     210                 215                 220                
 Asp Thr Phe Phe Pro Ser Pro Glu Ser Ser Cys Asp Val Lys Leu Val
 225                 230                 235                 240
 Glu Lys Ser Phe Glu Thr Asp Thr Asn Leu Asn Phe Gln Asn Leu Ser
                 245                 250                 255    
 Val Ile Gly Phe Arg Ile Leu Leu Leu Lys Val Ala Gly Phe Asn Leu
             260                 265                 270        
 Leu Met Thr Leu Arg Leu Trp Ser Ser
         275                 280    



      <210> 1191
      <211> 184
      <212> PRT
      <213> Homo sapiens


      <400> 1191
 Met Asn Met Leu Thr Ala Ser Leu Leu Arg Ala Val Ile Ala Ser Ile
   1               5                  10                  15    
 Cys Val Val Ser Ser Met Ala Gln Lys Val Thr Gln Ala Gln Thr Glu
              20                  25                  30        
 Ile Ser Val Val Glu Lys Glu Asp Val Thr Leu Asp Cys Val Tyr Glu
          35                  40                  45            
 Thr Arg Asp Thr Thr Tyr Tyr Leu Phe Trp Tyr Lys Gln Pro Pro Ser
      50                  55                  60                
 Gly Glu Leu Val Phe Leu Ile Arg Arg Asn Ser Phe Asp Glu Gln Asn
  65                  70                  75                  80
 Glu Ile Ser Gly Arg Tyr Ser Trp Asn Phe Gln Lys Ser Thr Ser Ser
                  85                  90                  95    
 Phe Asn Phe Thr Ile Thr Ala Ser Gln Val Val Asp Ser Ala Val Tyr
             100                 105                 110        
 Phe Cys Ala Leu Ser Glu Arg Asp Asp Lys Ile Ile Phe Gly Lys Gly
         115                 120                 125            
 Thr Arg Leu His Ile Leu Pro Asn Ile Gln Asn Pro Asp Pro Ala Val
     130                 135                 140                
 Tyr Gln Leu Arg Asp Ser Lys Ser Ser Asp Lys Ser Val Cys Leu Phe
 145                 150                 155                 160
 Thr Asp Phe Asp Ser Gln Thr Asn Val Ser Gln Ser Lys Asp Ser Asp
                 165                 170                 175    
 Val Tyr Ile Thr Asp Lys Leu Cys
             180                



      <210> 1192
      <211> 86
      <212> PRT
      <213> Homo sapiens


      <400> 1192
 Met Cys Val Gly Trp Gly Cys Val Cys Thr Cys Glu Cys Glu Cys Val
   1               5                  10                  15    
 Trp Ala Leu Gly Gly Gly Leu Gly Thr Ala Gly Arg Cys Gln Val His
              20                  25                  30        
 Leu Gly Leu Gly Leu Val Cys Trp Val Leu Lys Trp Asn Arg Phe Ile
          35                  40                  45            
 Pro Ala Met Glu Ala Thr Ser Arg Ser Val His Gly Asp Val Gly Glu
      50                  55                  60                
 Val Gly His Phe Glu Gly Met Ala Val Cys Trp Cys Pro Arg Arg Gly
  65                  70                  75                  80
 Ile Leu Pro Gly Leu Arg
                  85    



      <210> 1193
      <211> 80
      <212> PRT
      <213> Homo sapiens


      <400> 1193
 Met Glu Arg Ile Leu Ala Ser Ile Leu Thr Ser Leu Thr Ala Val Met
   1               5                  10                  15    
 Gly Val Leu Phe Leu Val Arg Cys Cys Val Thr Pro Cys Ile Cys Gly
              20                  25                  30        
 Leu Val Gln Arg Leu Ile Lys Met Ala Leu Thr Lys Thr Ser Leu Asn
          35                  40                  45            
 Tyr Pro Pro Pro Tyr Pro Glu Lys Leu Leu Leu Leu Glu Asn Gln Ala
      50                  55                  60                
 Lys Gln Leu Ser Gln Asp Met Leu Lys Lys Leu Leu Lys Arg Lys Leu
  65                  70                  75                  80





      <210> 1194
      <211> 101
      <212> PRT
      <213> Homo sapiens


      <400> 1194
 Met Ala Ala Trp Ser Pro Ala Ala Ala Ala Pro Leu Leu Arg Gly Ile
   1               5                  10                  15    
 Arg Gly Leu Pro Leu His His Arg Met Phe Ala Thr Gln Thr Glu Gly
              20                  25                  30        
 Glu Leu Arg Val Thr Gln Ile Leu Lys Glu Lys Phe Pro Arg Ala Thr
          35                  40                  45            
 Ala Ile Lys Val Thr Asp Ile Ser Gly Thr Lys Arg Arg Asn Gln Arg
      50                  55                  60                
 Asp Ala Trp Ile Ala Asp Ile Tyr Leu Cys Pro Gln Thr Leu Thr Thr
  65                  70                  75                  80
 Pro Trp Leu His Arg Cys Cys Cys Leu Arg Pro Trp Met Asn Phe Thr
                  85                  90                  95    
 Asp Ile Ile Leu Pro
             100    



      <210> 1195
      <211> 52
      <212> PRT
      <213> Homo sapiens


      <400> 1195
 Met Thr Ala Gly Cys Phe Thr Ile Leu Ser Leu Gly Leu Leu Ile Cys
   1               5                  10                  15    
 Lys Thr Gly Pro Ile Pro Ser Thr Pro Pro Phe Pro Gln Ala Asp Arg
              20                  25                  30        
 Gly Asn Phe Met Gly Tyr Arg Ile Gly Lys Cys Ile Leu Asn Cys Lys
          35                  40                  45            
 Val Leu Cys Thr
      50        



      <210> 1196
      <211> 103
      <212> PRT
      <213> Homo sapiens


      <400> 1196
 Met Ile Arg Ala Phe Pro Thr Thr Thr Pro Arg Ser Leu His Leu Phe
   1               5                  10                  15    
 Thr Ser Ser Thr Phe Leu Ala Arg Ala Leu Pro Gly Ala Phe Pro Thr
              20                  25                  30        
 Gly Ala Cys Glu Glu Arg Leu Ser Val Pro Glu Ser Thr Pro Phe Thr
          35                  40                  45            
 Ala Val Leu Lys Phe Ala Ala Glu Glu Phe Lys Val Pro Ala Ala Thr
      50                  55                  60                
 Ser Ala Ile Ile Thr Asn Asp Gly Ile Gly Ile Asn Pro Ala Gln Thr
  65                  70                  75                  80
 Ala Gly Asn Val Phe Leu Lys His Gly Ser Glu Leu Arg Ile Ile Pro
                  85                  90                  95    
 Arg Asp Arg Val Gly Ser Cys
             100            



      <210> 1197
      <211> 118
      <212> PRT
      <213> Homo sapiens


      <400> 1197
 Met Trp Gln Trp Lys Ala Gln Gly Leu Thr Pro Ala Ala Ala Ala Ala
   1               5                  10                  15    
 Ala Ala Asp Leu Ser Thr Pro Ala Arg Ala Glu Pro Pro Glu Ala Cys
              20                  25                  30        
 Ser Val Leu His His His Cys Asp Gly Ile Arg Phe Arg Asp Cys His
          35                  40                  45            
 Cys Ala Pro Ser Ala Cys Pro Gly Pro Thr Gln Asp Pro Gln Ala Gly
      50                  55                  60                
 Leu Cys Thr Gly Gln Glu Gly Tyr Pro Gly Thr Asp His Gly Leu Phe
  65                  70                  75                  80
 Met Gly Pro His Leu Leu Phe Gln Val Gln Gly Glu Arg Thr Asn Leu
                  85                  90                  95    
 Lys Val Glu Val Thr Glu Leu Gln Asp Val Glu Cys Glu Glu Trp Pro
             100                 105                 110        
 Arg Gly Ser Ser Ser Asn
         115            



      <210> 1198
      <211> 324
      <212> PRT
      <213> Homo sapiens


      <400> 1198
 Met Val Tyr Ser Ala Met Trp Trp Met Ala Thr Cys Leu Leu Cys His
   1               5                  10                  15    
 Leu Ser Ser Asp Cys Trp Thr Asp Ser Leu Ala Leu Ser Trp Cys Ser
              20                  25                  30        
 Pro Arg Glu Ala Arg Ser His Ser Pro Arg Ala Gln Pro Ser Ser Pro
          35                  40                  45            
 Thr Ala Pro Gln Ala Trp Ser His Gly Thr Leu Pro Ser Thr Leu Gln
      50                  55                  60                
 Asn Gly Pro Arg Thr Gln Gln Pro Ser Leu Thr Gly Asp Leu Gly Ala
  65                  70                  75                  80
 Gln Gly Arg Ala Pro Arg Gln Ala Tyr Pro Gly Ala Val Thr Asp Thr
                  85                  90                  95    
 Val Pro Phe Pro Pro Thr Arg Thr Val Leu Lys Leu Gly Ser Gly Ala
             100                 105                 110        
 Gly Leu Thr Gly Leu Ala Ile Cys Lys Met Cys Arg Pro Arg Ala Tyr
         115                 120                 125            
 Ile Phe Ser Asp Cys His Ser Arg Val Leu Glu Gln Leu Arg Gly Asn
     130                 135                 140                
 Val Leu Leu Asn Gly Leu Ser Leu Glu Ala Asp Ile Thr Ala Asn Leu
 145                 150                 155                 160
 Asp Gly Pro Arg Val Thr Val Ala Gln Leu Asp Trp Asp Val Ala Thr
                 165                 170                 175    
 Val Cys Gln Leu Ser Ala Val Gln Pro Asp Val Val Ile Ala Ala Gly
             180                 185                 190        
 Asn Ala Gln Pro Arg Ala Ser Cys Ala Gly Gly Val Leu Ala Ala Leu
         195                 200                 205            
 Thr Ser Ser Trp Leu Val Asp Val Leu Tyr Cys Pro Glu Ala Ile Val
     210                 215                 220                
 Ser Leu Val Gly Val Leu Arg Arg Leu Ala Ala Cys Arg Glu His Gln
 225                 230                 235                 240
 Arg Ala Pro Glu Val Tyr Val Ala Phe Thr Val His Asn Pro Gln Thr
                 245                 250                 255    
 Cys Gln Leu Phe Thr Thr Glu Leu Val Glu Ser Pro Arg Pro Pro Gly
             260                 265                 270        
 Pro Ala Trp Ser Pro Ser Cys Pro Cys Arg Thr Pro Val Glu Val Lys
         275                 280                 285            
 Glu Leu Gly Ala Gly Val Lys Leu Ala Cys Pro Thr Leu Pro His His
     290                 295                 300                
 Ala Gly Asn Ser Gly Arg Gly Arg Pro Gly Gln Asp Gln Met Gly Ser
 305                 310                 315                 320
 Gly Ser Leu Ser
                



      <210> 1199
      <211> 65
      <212> PRT
      <213> Homo sapiens


      <400> 1199
 Met Phe Gln Met Pro Phe Val Ser Ile Phe Leu Ile Ile Ile Phe Leu
   1               5                  10                  15    
 Glu Met Gly Ser Cys Tyr Ile Ala Gln Ala Gly Leu Glu Leu Leu Gly
              20                  25                  30        
 Ser Ser Asp Pro Pro Ala Leu Ala Ser Gln Ser Ala Gly Ile Ile Gly
          35                  40                  45            
 Met Asn Gln Arg Ala Gln Pro Gln Met Pro Phe Gly Trp Tyr Ile Thr
      50                  55                  60                
 Asn
  65



      <210> 1200
      <211> 202
      <212> PRT
      <213> Homo sapiens


      <400> 1200
 Met Gly Gln Pro Trp Ala Ala Gly Ser Thr Asp Gly Ala Pro Ala Gln
   1               5                  10                  15    
 Leu Pro Leu Val Leu Thr Ala Leu Trp Ala Ala Ala Val Gly Leu Glu
              20                  25                  30        
 Leu Ala Tyr Val Leu Val Leu Gly Pro Gly Pro Pro Pro Leu Gly Pro
          35                  40                  45            
 Leu Ala Arg Ala Leu Gln Leu Ala Leu Ala Ala Phe Gln Leu Leu Asn
      50                  55                  60                
 Leu Leu Gly Asn Val Gly Leu Phe Leu Arg Ser Asp Pro Ser Ile Arg
  65                  70                  75                  80
 Gly Val Met Leu Ala Gly Arg Gly Leu Gly Gln Gly Trp Ala Tyr Cys
                  85                  90                  95    
 Tyr Gln Cys Gln Ser Gln Val Pro Pro Arg Ser Gly His Cys Ser Ala
             100                 105                 110        
 Cys Arg Val Cys Ile Leu Arg Arg Asp His His Cys Arg Leu Leu Gly
         115                 120                 125            
 Arg Cys Val Gly Phe Gly Asn Tyr Arg Pro Phe Leu Cys Leu Leu Leu
     130                 135                 140                
 His Ala Ala Gly Val Leu Leu His Val Ser Val Leu Leu Gly Pro Ala
 145                 150                 155                 160
 Leu Ser Ala Leu Leu Arg Ala His Thr Pro Leu His Met Ala Ala Leu
                 165                 170                 175    
 Leu Leu Leu Pro Trp Leu Met Leu Leu Thr Ala Pro Ser Ser Leu Arg
             180                 185                 190        
 Asn Ser Asp Leu Gln Ala Thr Cys Thr Ser
         195                 200        



      <210> 1201
      <211> 182
      <212> PRT
      <213> Homo sapiens


      <400> 1201
 Met Ala Ala Val Ala Leu Ala Ser Gly Thr Arg Leu Gly Leu Val Leu
   1               5                  10                  15    
 Glu Leu Leu Pro Gly Gln Pro Ala Leu Pro Arg Ala Arg Arg Glu Ser
              20                  25                  30        
 Val Thr Phe Glu Asp Val Ala Val Tyr Phe Ser Glu Asn Glu Trp Ile
          35                  40                  45            
 Gly Leu Gly Pro Ala Gln Arg Ala Leu Tyr Arg Asp Val Met Leu Glu
      50                  55                  60                
 Asn Tyr Gly Ala Val Ala Ser Leu Ala Ala Phe Pro Phe Pro Lys Pro
  65                  70                  75                  80
 Ala Leu Ile Ser Gln Leu Glu Arg Gly Glu Thr Pro Trp Cys Ser Val
                  85                  90                  95    
 Pro Arg Gly Ala Leu Asp Gly Glu Ala Pro Arg Gly Ile Ser Ser Val
             100                 105                 110        
 Glu Lys Ser Trp Ala Pro Ser Leu Phe Pro Gly Thr Arg Tyr Asp Ile
         115                 120                 125            
 Glu Phe His Asp Tyr Ala Cys Thr Leu Gly Tyr Asn Pro Pro Gly Gly
     130                 135                 140                
 Arg Thr Ser Ile Val Ser Phe Phe Val Leu Pro Thr Glu Pro Val Gly
 145                 150                 155                 160
 Asp Leu His Thr Gly Ala Leu Gln Ser Val Leu Ile Glu Leu Leu Lys
                 165                 170                 175    
 Ala Ala Ser Leu Gln Ser
             180        



      <210> 1202
      <211> 167
      <212> PRT
      <213> Homo sapiens


      <400> 1202
 Met Ala Ala Val Ala Leu Ala Ser Gly Thr Arg Leu Gly Leu Val Leu
   1               5                  10                  15    
 Glu Leu Leu Pro Gly Gln Pro Ala Leu Pro Arg Ala Arg Arg Glu Ser
              20                  25                  30        
 Val Thr Phe Glu Asp Val Ala Val Tyr Phe Ser Glu Asn Glu Trp Ile
          35                  40                  45            
 Gly Leu Gly Pro Ala Gln Arg Ala Leu Tyr Arg Asp Val Met Leu Glu
      50                  55                  60                
 Asn Tyr Gly Ala Val Ala Ser Leu Ala Ala Phe Pro Phe Pro Lys Pro
  65                  70                  75                  80
 Ala Leu Ile Ser Gln Leu Glu Arg Gly Glu Thr Pro Trp Cys Ser Val
                  85                  90                  95    
 Pro Arg Gly Ala Leu Asp Gly Glu Ala Pro Arg Gly Ile Ser Ser Gly
             100                 105                 110        
 Glu Ile Leu Lys Leu Pro Gly Ala Thr Ile Trp Ser Leu Arg Ile Lys
         115                 120                 125            
 Pro Ile Pro Lys Lys Thr Val Thr Lys Gln Arg Glu Thr Arg Ser Leu
     130                 135                 140                
 Val Thr Ser Phe Glu Pro Leu Asp Gln Ala Leu Pro Glu Ala Glu Leu
 145                 150                 155                 160
 Pro Gln Asn Phe Ser Ala Met
                 165        



      <210> 1203
      <211> 128
      <212> PRT
      <213> Homo sapiens


      <400> 1203
 Met Ala Cys Arg Val Leu Gln Gly Leu Pro Phe Ala Cys Leu Ser Ser
   1               5                  10                  15    
 Pro Ile Cys Ser His Phe Ala Leu Thr Leu Asp His Ser Leu Leu Cys
              20                  25                  30        
 Leu Asn Phe Phe Phe Asn Pro Tyr Pro Leu Leu Pro Asn Phe Tyr Leu
          35                  40                  45            
 Phe Gly Lys Phe Gln Leu Arg Ile Pro Ser Ser Gly Lys Pro Phe Leu
      50                  55                  60                
 Thr Phe Glu Asp Gln Asp Pro Ala Gly Ile Phe Glu Leu Val Glu Val
  65                  70                  75                  80
 Val Gly Asn Gly Thr Tyr Gly Gln Val Tyr Lys Val Arg Arg Met Val
                  85                  90                  95    
 Trp Lys Tyr Asp Leu His Ile Cys Arg Ala Val Leu Gly Gly Val Glu
             100                 105                 110        
 Gly Ser Arg Phe Leu Val Cys Arg Ser Glu Gly Gly Tyr Gly Arg Cys
         115                 120                 125            





      <210> 1204
      <211> 239
      <212> PRT
      <213> Homo sapiens


      <400> 1204
 Met Ser Leu Lys Met Leu Ile Ser Arg Asn Lys Leu Ile Leu Leu Leu
   1               5                  10                  15    
 Gly Ile Val Phe Phe Glu Arg Gly Lys Ser Ala Thr Leu Ser Leu Pro
              20                  25                  30        
 Lys Ala Pro Ser Cys Gly Gln Ser Leu Val Lys Val Gln Pro Trp Asn
          35                  40                  45            
 Tyr Phe Asn Ile Phe Ser Arg Ile Leu Gly Gly Ser Gln Val Glu Lys
      50                  55                  60                
 Gly Ser Tyr Pro Trp Gln Val Ser Leu Lys Gln Arg Gln Lys His Ile
  65                  70                  75                  80
 Cys Gly Gly Ser Ile Val Ser Pro Gln Trp Val Ile Thr Ala Ala His
                  85                  90                  95    
 Cys Ile Ala Asn Arg Asn Ile Val Ser Thr Leu Asn Val Thr Ala Gly
             100                 105                 110        
 Glu Tyr Asp Leu Ser Gln Thr Asp Pro Gly Glu Gln Thr Leu Thr Ile
         115                 120                 125            
 Glu Thr Val Ile Ile His Pro His Phe Ser Thr Lys Lys Pro Met Asp
     130                 135                 140                
 Tyr Asp Ile Ala Leu Leu Lys Met Ala Gly Ala Phe Gln Phe Gly His
 145                 150                 155                 160
 Phe Val Gly Pro Ile Cys Leu Pro Glu Leu Arg Glu Gln Phe Glu Ala
                 165                 170                 175    
 Gly Phe Ile Cys Thr Thr Ala Gly Trp Gly Arg Leu Thr Glu Gly Gly
             180                 185                 190        
 Val Leu Ser Gln Val Leu Leu Ser Val Tyr Leu Cys Lys Ser Asp Ala
         195                 200                 205            
 Phe Ser Phe Leu Glu Thr Thr Leu Cys Trp Thr Pro Met Met Pro Ala
     210                 215                 220                
 Trp Arg Met Val Ser Lys Ala Ala Ser Gly Pro Gln Arg His Thr
 225                 230                 235                



      <210> 1205
      <211> 118
      <212> PRT
      <213> Homo sapiens


      <400> 1205
 Met Gly Thr Ala Lys Ala Asn His Trp Ala Trp Leu Leu Val Leu Arg
   1               5                  10                  15    
 Phe Val Phe Gly Cys Asn Val Leu Gln Ile Leu Leu Pro Ser Phe Ser
              20                  25                  30        
 Ser Phe Met Ser Arg Val Gln Arg Lys Asp Ala Glu Gln Glu Ser Gln
          35                  40                  45            
 Thr Lys Ala Glu Ile Gln Asp Met Lys Gln Glu Leu Ser Ala Val Asn
      50                  55                  60                
 Met Met Asp Lys Phe Ala Arg Ser Ala Arg Leu Glu Arg Lys Ile Asn
  65                  70                  75                  80
 Lys Met Met Asn Lys Leu Lys Thr His Val Lys Val Gln Thr Ala Gln
                  85                  90                  95    
 Ser Gly Met Leu Lys Trp Val Ile Ser Val Ala Phe Tyr Lys Leu Pro
             100                 105                 110        
 Gly Thr Val Ile Arg Leu
         115            



      <210> 1206
      <211> 81
      <212> PRT
      <213> Homo sapiens


      <400> 1206
 Met Leu Trp Gly Phe Cys Gly Gln Ala Pro Pro Phe Pro Gly His Gly
   1               5                  10                  15    
 Thr Arg Thr Ala Leu Met Ala Thr Ala Arg Arg Gly Ala Phe Val Ser
              20                  25                  30        
 Pro Cys Ala Val Ser Val Phe Ser Thr Thr Ser Leu Pro Cys Pro Leu
          35                  40                  45            
 Gly Tyr Leu Leu Ile Tyr Leu Leu Cys Ala Ser Asp Gly Gly Trp Gly
      50                  55                  60                
 Leu Gly Leu Pro Arg His Leu His Pro Cys Cys Asp Leu Ser Phe Arg
  65                  70                  75                  80
 Thr
    



      <210> 1207
      <211> 491
      <212> PRT
      <213> Homo sapiens


      <400> 1207
 Met His Ala Ala Ala Asn Gln Thr Pro Gly Ser Arg Ala Trp Ala His
   1               5                  10                  15    
 Gln Arg Gln Cys Gly Val Gln Gly Leu Leu Val Leu Trp Ser His Pro
              20                  25                  30        
 Leu Met Leu Val Ser Thr Tyr Pro Ser Val Ser Pro Glu Val Asp Ser
          35                  40                  45            
 Val Gly Ser Trp Ser Asp Pro Ala Gly Cys Asp Pro Gln Asp Arg Met
      50                  55                  60                
 Val Leu Asp Ser Gly Ser Gln Ala Tyr Asp Gln Ala Pro Thr Ser Pro
  65                  70                  75                  80
 Pro Thr Ser Leu Leu Ser Leu Arg His Arg Leu Lys His Ser Asp Arg
                  85                  90                  95    
 Asp Gly Pro Pro Leu Tyr Pro Trp Ser Gln Ser Leu Ala Leu Pro Val
             100                 105                 110        
 Ala Leu Ala Val Pro Pro Ala Leu Gln Pro Gln Pro Glu Gln Gln Ser
         115                 120                 125            
 Phe Ser Gln Met His Leu Gly His Gly Gly His Met Arg Arg Ser Glu
     130                 135                 140                
 Ser Thr Tyr Ser Val Asn Ser Thr Gly Arg Arg Gly Arg Gly Thr Leu
 145                 150                 155                 160
 Gly Gln Pro Pro Pro Gly Arg Arg Trp Asn Pro Gly Gly Arg Thr Leu
                 165                 170                 175    
 Arg Pro Ala Ala Ser Leu Pro His Ile Thr Lys Thr Gln Ser Asp Ala
             180                 185                 190        
 Gly His Ser Ala Ser Lys Ser Pro Cys Met Leu Val Ala Leu Arg Pro
         195                 200                 205            
 Thr Asn Phe Glu Tyr Gln Glu Pro Met Pro Met Ala Val Leu Lys Tyr
     210                 215                 220                
 Cys Glu Ala Ser Gly Gln Phe Ile His Gln Ala Val Gly Ile Ile Glu
 225                 230                 235                 240
 Ala Val Leu Glu Lys Phe Gly Thr Tyr Glu His Phe Glu Ala Ala Thr
                 245                 250                 255    
 Gly Arg Gln Leu Leu Thr Lys Cys Gln Ile Trp Ser Ile Val Glu Leu
             260                 265                 270        
 Ala Gln Asn Met Leu Arg Tyr Ala Leu Gly Ser Pro Ser Ser Leu Gly
         275                 280                 285            
 Arg Phe Gly Tyr Ser Phe Val Ser Pro Leu Pro Leu Arg Leu Leu Ser
     290                 295                 300                
 Thr Val Ala Ala Gly Leu Gly Gln Leu Gln Leu Leu Leu Gly Tyr Ala
 305                 310                 315                 320
 Ser Leu Cys Gln Arg Pro Ala Val Arg Val Trp Ala Lys Thr Gly Lys
                 325                 330                 335    
 Ala Glu Ala Ser Gly Gly Ser Gly Asp Arg Ala Lys Gly Ala Leu Gly
             340                 345                 350        
 Leu Asp Ser Gln Gly Leu Asn His Ser Val Cys Ser Thr Pro Ser Ser
         355                 360                 365            
 Gly His Gln Ser Pro Gln Glu Lys Gly Ser Arg Pro Pro Pro Gly Pro
     370                 375                 380                
 Ser Glu Lys Gln Thr Ala Arg Met Leu Lys Glu His Gln Gly Asp Arg
 385                 390                 395                 400
 Asn Thr Gln Thr Val Glu Ala Gln Ser Lys Gln Leu His Val Leu Gly
                 405                 410                 415    
 Ala Tyr Leu Glu Leu Leu Ser Arg Ala Ser Val Cys Ser Pro Gln Pro
             420                 425                 430        
 Thr Ser Val Gly Gln Gln Ala Thr Gln Leu Arg His Ile Gln Pro Val
         435                 440                 445            
 Gly Gly His Asp Val Leu Gln Leu Leu Pro Val Ala Cys Gln Val Leu
     450                 455                 460                
 His Lys Val Gly His Pro Gly Ile Ile Gln His Pro Met Gly Pro Gln
 465                 470                 475                 480
 Val Val His Ile Leu Ile Gly His Leu Ala Gln
                 485                 490    



      <210> 1208
      <211> 199
      <212> PRT
      <213> Homo sapiens


      <400> 1208
 Met Arg Leu Leu Cys Gly Leu Trp Leu Trp Leu Ser Leu Leu Lys Val
   1               5                  10                  15    
 Leu Gln Ala Gln Thr Pro Thr Pro Leu Pro Leu Pro Pro Pro Met Gln
              20                  25                  30        
 Ser Phe Gln Gly Asn Gln Phe Gln Gly Glu Trp Phe Val Leu Gly Leu
          35                  40                  45            
 Ala Gly Asn Ser Phe Arg Pro Glu His Arg Ala Leu Leu Asn Ala Phe
      50                  55                  60                
 Thr Ala Thr Phe Glu Leu Ser Asp Asp Gly Arg Phe Glu Val Trp Asn
  65                  70                  75                  80
 Ala Met Thr Arg Gly Gln His Cys Asp Thr Trp Ser Tyr Val Leu Ile
                  85                  90                  95    
 Pro Ala Ala Gln Pro Gly Gln Phe Thr Val Asp His Gly Val Glu Pro
             100                 105                 110        
 Gly Ala Asp Arg Glu Glu Thr Arg Val Val Asp Ser Asp Tyr Thr Gln
         115                 120                 125            
 Phe Ala Leu Met Leu Ser Arg Arg His Thr Ser Arg Leu Ala Val Leu
     130                 135                 140                
 Arg Ile Ser Leu Leu Gly Arg Ser Trp Leu Leu Pro Pro Gly Thr Leu
 145                 150                 155                 160
 Asp Gln Phe Ile Cys Leu Gly Arg Ala Gln Gly Leu Ser Asp Asp Asn
                 165                 170                 175    
 Ile Val Phe Pro Asp Val Thr Gly Gly Ala Leu Asp Leu Ser Ser Leu
             180                 185                 190        
 Pro Trp Val Ala Ala Pro Ala
         195                



      <210> 1209
      <211> 77
      <212> PRT
      <213> Homo sapiens


      <400> 1209
 Met Cys Arg Ser Phe Pro Pro Gln Glu Tyr Ile Asn Ile Asn Pro Tyr
   1               5                  10                  15    
 Phe Leu Met Glu Leu Val Trp Phe Arg Phe Leu His Leu Asn Leu Leu
              20                  25                  30        
 Pro Arg Gly Val Cys Cys Gly Ile Cys Val Cys Val Arg Arg Gly Met
          35                  40                  45            
 Val Leu Ser Glu Pro Thr Ser Cys Gly Gln Arg Ala Leu Ser Cys Glu
      50                  55                  60                
 Gly Gly Tyr His Ser Gly Arg Val Gln Phe Arg Arg Pro
  65                  70                  75        



      <210> 1210
      <211> 114
      <212> PRT
      <213> Homo sapiens


      <400> 1210
 Met Met Arg Leu Ser Leu Val Val Leu Lys Val Ala Val Thr Leu Lys
   1               5                  10                  15    
 Asn Asp Phe Pro Gly Asn Gln Asn Ile Gln Val Gly Leu Lys Leu Ala
              20                  25                  30        
 Ala Lys Gln Glu Leu Trp Gln Ala Gly Glu Asp Ser Asp Ala Trp Asn
          35                  40                  45            
 Phe Leu Ser Tyr Arg Pro Thr Pro Asp Leu Lys Ala Ser Val Lys Val
      50                  55                  60                
 Ser Gly Cys Gln Ser Ala Glu Leu Ser Gly Lys Met Met Met Asn Glu
  65                  70                  75                  80
 Val Leu Ala Ala Ser Cys Val Pro Gly Leu Val Glu Ile Asn Glu Thr
                  85                  90                  95    
 Asp Val Leu Gln Ser Ser Asn Val His His Ile Gly Ser Cys Leu Arg
             100                 105                 110        
 Lys Arg
        



      <210> 1211
      <211> 113
      <212> PRT
      <213> Homo sapiens


      <400> 1211
 Met Arg Lys Leu Ile Ala Glu Leu Ile Phe Leu Lys Ile Trp Thr Phe
   1               5                  10                  15    
 Thr Val Arg Thr Ser Thr Asp Leu Pro Gln Thr Glu Asp Cys Ser Gln
              20                  25                  30        
 Tyr Ile His Gln Val Thr Glu Val Gly Gln Lys Val Ala Met Val Leu
          35                  40                  45            
 Leu Phe Tyr Ser Tyr His Lys Cys Thr Arg Thr Leu Lys Lys Pro Cys
      50                  55                  60                
 Leu Tyr Asn Val Ile Leu Tyr Lys Val Cys Ser Pro Gly Asn Asp Gln
  65                  70                  75                  80
 Pro Asp Val Arg Tyr Asp Pro Pro Glu Pro Pro Met Ile Thr Val Phe
                  85                  90                  95    
 Lys Ile Arg Leu Arg His Cys Arg Leu Val Gly Ala His Lys Arg Tyr
             100                 105                 110        
 Glu
    



      <210> 1212
      <211> 490
      <212> PRT
      <213> Homo sapiens


      <400> 1212
 Met Gly Arg Pro Thr Gln Trp Pro Ser Leu Leu Leu Leu Leu Leu Leu
   1               5                  10                  15    
 Pro Gly Pro Pro Pro Val Ala Gly Leu Glu Asp Ala Ala Phe Pro His
              20                  25                  30        
 Leu Gly Glu Ser Leu Gln Pro Leu Pro Arg Ala Cys Pro Leu Arg Cys
          35                  40                  45            
 Ser Cys Pro Arg Val Asp Thr Val Asp Cys Asp Gly Leu Asp Leu Arg
      50                  55                  60                
 Val Phe Pro Asp Asn Ile Thr Arg Ala Ala Gln His Leu Ser Leu Gln
  65                  70                  75                  80
 Asn Asn Gln Leu Gln Glu Leu Pro Tyr Asn Glu Leu Ser Arg Leu Ser
                  85                  90                  95    
 Gly Leu Arg Thr Leu Asn Leu His Asn Asn Leu Ile Ser Ser Glu Gly
             100                 105                 110        
 Leu Pro Asp Glu Ala Phe Glu Ser Leu Thr Gln Leu Gln His Leu Cys
         115                 120                 125            
 Val Ala His Asn Lys Asn Asn Leu Ile Ser Lys Val Pro Arg Gly Ala
     130                 135                 140                
 Leu Ser Arg Gln Thr Gln Leu Arg Glu Leu Tyr Leu Gln His Asn Gln
 145                 150                 155                 160
 Leu Thr Asp Ser Gly Leu Asp Ala Thr Thr Phe Ser Lys Leu His Ser
                 165                 170                 175    
 Leu Glu Tyr Leu Asp Leu Ser His Asn Gln Leu Thr Thr Val Pro Ala
             180                 185                 190        
 Gly Leu Pro Arg Thr Leu Ala Ile Leu His Leu Gly Arg Asn Arg Ile
         195                 200                 205            
 Arg Gln Val Glu Ala Ala Arg Leu His Gly Ala Arg Gly Leu Arg Tyr
     210                 215                 220                
 Leu Leu Leu Gln His Asn Gln Leu Gly Ser Ser Gly Leu Pro Ala Gly
 225                 230                 235                 240
 Ala Leu Arg Pro Leu Arg Gly Leu His Thr Leu His Leu Tyr Gly Asn
                 245                 250                 255    
 Gly Leu Asp Arg Val Pro Pro Ala Leu Pro Arg Arg Leu Arg Ala Leu
             260                 265                 270        
 Val Leu Pro His Asn His Val Ala Ala Leu Gly Ala Arg Asp Leu Val
         275                 280                 285            
 Ala Thr Pro Gly Leu Thr Glu Leu Asn Leu Ala Tyr Asn Arg Leu Ala
     290                 295                 300                
 Ser Ala Arg Val His His Arg Ala Phe Arg Arg Leu Arg Ala Leu Arg
 305                 310                 315                 320
 Ser Leu Asp Leu Ala Gly Asn Gln Leu Thr Arg Leu Pro Met Gly Leu
                 325                 330                 335    
 Pro Thr Gly Leu Arg Thr Leu Gln Leu Gln Arg Asn Gln Leu Arg Met
             340                 345                 350        
 Leu Glu Pro Glu Pro Leu Ala Gly Leu Asp Gln Leu Arg Glu Leu Ser
         355                 360                 365            
 Leu Ala His Asn Arg Leu Arg Val Gly Asp Ile Gly Pro Gly Thr Trp
     370                 375                 380                
 His Glu Leu Gln Ala Leu Gln Met Leu Asp Leu Ser His Asn Glu Leu
 385                 390                 395                 400
 Ser Phe Val Pro Pro Asp Leu Pro Glu Ala Leu Glu Glu Leu His Leu
                 405                 410                 415    
 Glu Gly Asn Arg Ile Gly His Val Gly Pro Glu Ala Phe Leu Ser Thr
             420                 425                 430        
 Pro Arg Leu Arg Ala Leu Phe Leu Arg Ala Asn Arg Leu His Met Thr
         435                 440                 445            
 Ser Ile Ala Ala Glu Ala Phe Leu Gly Leu Pro Asn Leu Arg Val Val
     450                 455                 460                
 Asp Thr Ala Gly Asn Pro Glu Gln Val Leu Ile Arg Leu Pro Pro Thr
 465                 470                 475                 480
 Thr Pro Arg Gly Pro Arg Ala Gly Gly Pro
                 485                 490



      <210> 1213
      <211> 287
      <212> PRT
      <213> Homo sapiens


      <400> 1213
 Met Lys Pro Leu Leu Glu Thr Leu Tyr Leu Leu Gly Met Leu Val Pro
   1               5                  10                  15    
 Gly Gly Leu Gly Tyr Asp Arg Ser Leu Ala Gln His Arg Gln Glu Ile
              20                  25                  30        
 Val Asp Lys Ser Val Ser Pro Trp Ser Leu Glu Thr Tyr Ser Tyr Asn
          35                  40                  45            
 Ile Tyr His Pro Met Gly Glu Ile Tyr Glu Trp Met Arg Glu Ile Ser
      50                  55                  60                
 Glu Lys Tyr Lys Glu Val Val Thr Gln His Phe Leu Gly Val Thr Tyr
  65                  70                  75                  80
 Glu Thr His Pro Ile Tyr Tyr Leu Lys Ile Ser Gln Pro Ser Gly Asn
                  85                  90                  95    
 Pro Lys Lys Ile Ile Trp Met Asp Cys Gly Ile His Ala Arg Glu Trp
             100                 105                 110        
 Ile Ala Pro Ala Phe Cys Gln Trp Phe Val Lys Glu Ile Leu Gln Asn
         115                 120                 125            
 His Lys Asp Asn Ser Arg Ile Arg Lys Leu Leu Arg Asn Leu Asp Phe
     130                 135                 140                
 Tyr Val Leu Pro Val Leu Asn Ile Asp Gly Tyr Ile Tyr Thr Trp Thr
 145                 150                 155                 160
 Thr Asp Arg Leu Trp Arg Lys Ser Arg Ser Pro His Asn Asn Gly Thr
                 165                 170                 175    
 Cys Phe Gly Thr Asp Leu Asn Arg Asn Phe Asn Ala Ser Trp Cys Ser
             180                 185                 190        
 Ile Gly Ala Ser Arg Asn Cys Gln Asp Gln Thr Phe Cys Gly Thr Gly
         195                 200                 205            
 Pro Val Ser Glu Pro Glu Thr Lys Ala Val Ala Ser Phe Ile Glu Ser
     210                 215                 220                
 Lys Lys Asp Asp Ile Leu Cys Phe Leu Thr Met His Ser Tyr Gly Gln
 225                 230                 235                 240
 Leu Ile Leu Thr Pro Tyr Gly Tyr Thr Lys Asn Lys Ser Ser Asn His
                 245                 250                 255    
 Pro Glu Met Ile Gln Val Gly Gln Lys Ala Ala Tyr Ala Leu Lys Ala
             260                 265                 270        
 Lys Tyr Gly Thr Asn Tyr Arg Ser Gly Ser Ser Ala Asp Ile Leu
         275                 280                 285        



      <210> 1214
      <211> 114
      <212> PRT
      <213> Homo sapiens


      <400> 1214
 Met Leu Leu Trp Ser Leu Leu Val Ile Phe Asp Ala Val Thr Glu Gln
   1               5                  10                  15    
 Ala Asp Ser Leu Thr Leu Val Ala Pro Ser Ser Val Phe Glu Gly Asp
              20                  25                  30        
 Ser Ile Val Leu Lys Cys Gln Gly Glu Gln Asn Trp Lys Ile Gln Lys
          35                  40                  45            
 Met Ala Tyr His Lys Asp Asn Lys Glu Leu Ser Val Phe Lys Lys Phe
      50                  55                  60                
 Ser Asp Phe Leu Ile Gln Ser Ala Val Leu Ser Asp Ser Gly Asn Tyr
  65                  70                  75                  80
 Phe Cys Ser Thr Lys Gly Gln Leu Phe Leu Trp Asp Lys Thr Ser Asn
                  85                  90                  95    
 Ile Val Lys Ile Lys Val Gln Gly Lys Thr Leu Thr Ser Val Gly Trp
             100                 105                 110        
 Ala Gly
        



      <210> 1215
      <211> 202
      <212> PRT
      <213> Homo sapiens


      <400> 1215
 Met Glu Ala Ala Leu Leu Gly Leu Cys Asn Trp Ser Thr Leu Gly Val
   1               5                  10                  15    
 Cys Ala Ala Leu Lys Leu Pro Gln Ile Ser Ala Val Leu Ala Ala Arg
              20                  25                  30        
 Ser Ala Arg Gly Leu Ser Leu Pro Ser Leu Leu Leu Glu Leu Ala Gly
          35                  40                  45            
 Phe Leu Val Phe Leu Arg Tyr Gln Cys Tyr Tyr Gly Tyr Pro Pro Leu
      50                  55                  60                
 Thr Tyr Leu Glu Tyr Pro Ile Leu Ile Ala Gln Asp Val Ile Leu Leu
  65                  70                  75                  80
 Leu Cys Ile Phe His Phe Asn Gly Asn Val Lys Gln Ala Thr Pro Tyr
                  85                  90                  95    
 Ile Ala Val Leu Val Ser Ser Trp Phe Ile Leu Ala Leu Gln Lys Trp
             100                 105                 110        
 Ile Ile Asp Leu Ala Met Asn Leu Cys Thr Phe Ile Ser Ala Ala Ser
         115                 120                 125            
 Lys Phe Ala Gln Leu Gln Cys Leu Trp Lys Thr Arg Asp Ser Gly Thr
     130                 135                 140                
 Val Ser Ala Leu Thr Trp Ser Leu Ser Ser Tyr Thr Cys Ala Thr Arg
 145                 150                 155                 160
 Ile Ile Thr Thr Leu Met Thr Thr Asn Asp Phe Thr Ile Leu Leu Arg
                 165                 170                 175    
 Phe Val Ile Met Leu Ala Leu Asn Ile Trp Val Thr Val Thr Val Leu
             180                 185                 190        
 Arg Tyr Arg Lys Thr Ala Ile Lys Ala Glu
         195                 200        



      <210> 1216
      <211> 187
      <212> PRT
      <213> Homo sapiens


      <400> 1216
 Met Gly Pro Gly Arg Cys Leu Leu Thr Ala Leu Leu Leu Leu Ala Leu
   1               5                  10                  15    
 Ala Pro Pro Pro Glu Ala Ser Gln Tyr Cys Gly Arg Leu Glu Tyr Trp
              20                  25                  30        
 Asn Pro Asp Asn Lys Cys Cys Ser Ser Cys Leu Gln Arg Phe Gly Pro
          35                  40                  45            
 Pro Pro Cys Pro Gly Ala Leu Glu Thr Gly Asp Thr Trp Lys Glu Ala
      50                  55                  60                
 Ser Leu Leu Pro Leu Leu Ser Arg Glu Leu Ser Ser Leu Ala Ser Gln
  65                  70                  75                  80
 Pro Leu Ser Arg Leu Leu Asp Glu Leu Glu Val Leu Glu Glu Leu Ile
                  85                  90                  95    
 Val Leu Leu Asp Pro Glu Pro Gly Pro Gly Gly Gly Met Ala His Gly
             100                 105                 110        
 Thr Thr Arg His Leu Ala Ala Arg Tyr Gly Leu Pro Ala Ala Trp Ser
         115                 120                 125            
 Thr Phe Ala Tyr Ser Leu Arg Pro Ser Arg Ser Pro Leu Arg Ala Leu
     130                 135                 140                
 Ile Glu Met Val Val Ala Arg Glu Pro Ser Ala Ser Leu Gly Gln Leu
 145                 150                 155                 160
 Gly Thr His Leu Ala His Leu Gly Arg Ala Asp Ala Leu Arg Val Leu
                 165                 170                 175    
 Ser Lys Leu Gly Ser Ser Gly Val Cys Trp Ala
             180                 185        



      <210> 1217
      <211> 167
      <212> PRT
      <213> Homo sapiens


      <400> 1217
 Met Gly Pro Gly Arg Cys Leu Leu Thr Ala Leu Leu Leu Leu Ala Leu
   1               5                  10                  15    
 Ala Pro Pro Pro Glu Ala Ser Gln Tyr Cys Gly Arg Leu Glu Tyr Trp
              20                  25                  30        
 Asn Pro Asp Asn Lys Cys Cys Ser Ser Cys Leu Gln Arg Phe Gly Pro
          35                  40                  45            
 Pro Pro Cys Pro Asp Leu Leu Asn Thr Ala Tyr Pro Arg Leu Asp Gly
      50                  55                  60                
 Leu Leu Asp Glu Leu Glu Val Leu Glu Glu Leu Ile Val Leu Leu Asp
  65                  70                  75                  80
 Pro Glu Pro Gly Pro Gly Gly Gly Met Ala His Gly Thr Thr Arg His
                  85                  90                  95    
 Leu Ala Ala Arg Tyr Gly Leu Pro Ala Ala Trp Ser Thr Phe Ala Tyr
             100                 105                 110        
 Ser Leu Arg Pro Ser Arg Ser Pro Leu Arg Ala Leu Ile Glu Met Val
         115                 120                 125            
 Val Ala Arg Glu Pro Ser Ala Ser Leu Gly Gln Leu Gly Thr His Leu
     130                 135                 140                
 Ala Gln Leu Gly Arg Ala Asp Ala Leu Arg Val Leu Ser Lys Leu Gly
 145                 150                 155                 160
 Ser Ser Gly Val Cys Trp Ala
                 165        



      <210> 1218
      <211> 115
      <212> PRT
      <213> Homo sapiens


      <400> 1218
 Met Leu Gly Gly Leu Val Gly Thr Ile Thr Leu Gly Leu Pro Leu Ser
   1               5                  10                  15    
 Ile Glu Gly Trp Ala Gln Ser Pro Ser Gly Arg Ala Gly Glu Gly Gly
              20                  25                  30        
 Phe Ser His Gln Ala Pro His Ile His Ala Arg Pro Gln Val Thr Pro
          35                  40                  45            
 Pro Cys Cys Leu Gly Ser Leu Ala Leu Arg Gln Pro Cys Ala Glu Ala
      50                  55                  60                
 Leu Glu Trp Asp Val Pro Leu Gly Glu Gly Asp Met Gly Ala Arg Pro
  65                  70                  75                  80
 Cys Ala Arg Arg Phe Pro Leu Ala Pro Thr Thr Gly Arg Lys Ala Gly
                  85                  90                  95    
 Trp Gly Leu Arg Leu Arg Gly Ser Leu His Glu Cys Gly Arg Asp Trp
             100                 105                 110        
 Pro Gly Pro
         115



      <210> 1219
      <211> 48
      <212> PRT
      <213> Homo sapiens


      <400> 1219
 Met Ser Arg Met Ile Leu Phe Thr Val Leu Phe Arg Val Cys Ile Glu
   1               5                  10                  15    
 Ser Asp Ile Leu Tyr Met Leu Val Thr Cys Ile Met Thr Asn Ser Leu
              20                  25                  30        
 Ser Cys Pro Pro Gly Ser Ser Phe Ser Tyr Phe Leu Phe Leu Leu Ser
          35                  40                  45            





      <210> 1220
      <211> 47
      <212> PRT
      <213> Homo sapiens


      <400> 1220
 Met Ile Asn Asn Ile Ser Cys Ser Ser Phe Leu Tyr Leu Leu Trp Tyr
   1               5                  10                  15    
 Lys Phe Gly Cys Ser Ser Asn Asn Lys Thr Ile Tyr Ile Phe Asn Ile
              20                  25                  30        
 Phe Lys Tyr His Tyr Tyr Cys Tyr Leu Leu Val Ser Val Thr Ile
          35                  40                  45        



      <210> 1221
      <211> 274
      <212> PRT
      <213> Homo sapiens


      <400> 1221
 Met Phe Val Leu Leu Tyr Val Thr Ser Phe Ala Ile Cys Ala Ser Gly
   1               5                  10                  15    
 Gln Pro Arg Gly Asn Gln Leu Lys Gly Glu Asn Tyr Ser Pro Arg Tyr
              20                  25                  30        
 Ile Cys Ser Ile Pro Gly Leu Pro Gly Pro Pro Gly Pro Pro Gly Ala
          35                  40                  45            
 Asn Gly Ser Pro Gly Pro His Gly Arg Ile Gly Leu Pro Gly Arg Asp
      50                  55                  60                
 Gly Arg Asp Gly Arg Lys Gly Glu Lys Gly Glu Lys Gly Thr Ala Gly
  65                  70                  75                  80
 Leu Arg Gly Lys Thr Gly Pro Leu Gly Leu Ala Gly Glu Lys Gly Asp
                  85                  90                  95    
 Gln Gly Glu Thr Gly Lys Lys Gly Pro Ile Gly Pro Lys Gly Asp Arg
             100                 105                 110        
 Gly Glu Gln Gly Asp Pro Gly Leu Pro Gly Val Cys Arg Cys Gly Ser
         115                 120                 125            
 Ile Val Leu Lys Ser Ala Phe Ser Val Gly Ile Thr Thr Ser Tyr Pro
     130                 135                 140                
 Glu Glu Arg Leu Pro Ile Ile Phe Asn Lys Val Leu Phe Asn Glu Gly
 145                 150                 155                 160
 Glu His Tyr Asn Pro Ala Thr Gly Lys Phe Ile Cys Ala Phe Pro Gly
                 165                 170                 175    
 Ile Tyr Tyr Phe Ser Tyr Asp Ile Thr Leu Ala Asn Lys His Leu Ala
             180                 185                 190        
 Ile Gly Leu Val His Asn Gly Gln Tyr Arg Ile Lys Thr Phe Asp Ala
         195                 200                 205            
 Asn Thr Gly Asn His Asp Val Ala Ser Gly Ser Thr Val Ile Tyr Leu
     210                 215                 220                
 Gln Pro Glu Asp Glu Val Trp Leu Glu Ile Phe Phe Thr Asp Gln Asn
 225                 230                 235                 240
 Gly Leu Phe Ser Asp Pro Gly Trp Ala Asp Ser Leu Phe Ser Gly Phe
                 245                 250                 255    
 Leu Leu Tyr Val Asp Thr Asp Tyr Ile Asp Ser Ile Ser Glu Asp Asp
             260                 265                 270        
 Glu Leu
        



      <210> 1222
      <211> 127
      <212> PRT
      <213> Homo sapiens


      <400> 1222
 Met Asn Leu Cys Met Gly Val Leu Leu Lys Trp Tyr Phe Lys Lys Val
   1               5                  10                  15    
 Pro Leu Phe Thr Leu Val Leu His Cys His Ala Thr Arg Trp Cys Arg
              20                  25                  30        
 Ser Pro Lys Cys His Pro Pro Pro Ser Phe Pro Leu Cys Ser Lys Ser
          35                  40                  45            
 Ser Gly Leu Leu Gly Leu Gly Gln Met Val Val Cys Val Ile Arg Thr
      50                  55                  60                
 Arg Gly Val Leu Cys Val Glu His Ser Pro Gln Pro Lys Leu Gly Ser
  65                  70                  75                  80
 Gln Leu Arg Gly Gln Ala Met Leu Gly Cys Leu Gly Lys Val Met His
                  85                  90                  95    
 Tyr Gln Glu Thr Tyr Leu Leu Ser Pro Ala Leu Tyr Pro Gln Ala Leu
             100                 105                 110        
 Ile Trp Arg Thr Leu Cys Thr Thr Arg Thr Thr Pro Thr Thr Leu
         115                 120                 125        



      <210> 1223
      <211> 1068
      <212> PRT
      <213> Homo sapiens


      <400> 1223
 Met Pro Ala Ala Arg Arg Phe Pro Gly Leu Glu Leu Ser Phe Pro Leu
   1               5                  10                  15    
 Leu Ala Arg Leu Arg Arg Arg Leu Tyr Thr Arg Leu Gly Gly Gly Arg
              20                  25                  30        
 Met Gln Pro Glu Glu Gly Thr Gly Trp Leu Leu Glu Leu Leu Ser Glu
          35                  40                  45            
 Val Gln Leu Gln Gln Tyr Phe Leu Arg Leu Arg Asp Asp Leu Asn Val
      50                  55                  60                
 Thr Arg Leu Ser His Phe Glu Tyr Val Lys Asn Glu Asp Leu Glu Lys
  65                  70                  75                  80
 Ile Gly Met Gly Arg Pro Gly Gln Arg Arg Leu Trp Glu Ala Val Lys
                  85                  90                  95    
 Arg Arg Lys Ala Leu Cys Lys Arg Lys Ser Trp Met Ser Lys Val Phe
             100                 105                 110        
 Ser Gly Lys Arg Leu Glu Ala Glu Phe Pro Pro His His Ser Gln Ser
         115                 120                 125            
 Thr Phe Arg Lys Thr Ser Pro Ala Pro Gly Gly Pro Ala Gly Glu Gly
     130                 135                 140                
 Pro Leu Gln Ser Leu Thr Cys Leu Ile Gly Glu Lys Asp Leu Arg Leu
 145                 150                 155                 160
 Leu Glu Lys Leu Gly Asp Gly Ser Phe Gly Val Val Arg Arg Gly Glu
                 165                 170                 175    
 Trp Asp Ala Pro Ser Gly Lys Thr Val Ser Val Ala Val Lys Cys Leu
             180                 185                 190        
 Lys Pro Asp Val Leu Ser Gln Pro Glu Ala Met Asp Asp Phe Ile Arg
         195                 200                 205            
 Glu Val Asn Ala Met His Ser Leu Asp His Arg Asn Leu Ile Arg Leu
     210                 215                 220                
 Tyr Gly Val Val Leu Thr Pro Pro Met Lys Met Val Thr Glu Leu Ala
 225                 230                 235                 240
 Pro Leu Gly Ser Leu Leu Asp Arg Leu Arg Lys His Gln Gly His Phe
                 245                 250                 255    
 Leu Leu Gly Thr Leu Ser Arg Tyr Ala Val Gln Val Ala Glu Gly Met
             260                 265                 270        
 Gly Tyr Leu Glu Ser Lys Arg Phe Ile His Arg Asp Leu Ala Ala Arg
         275                 280                 285            
 Asn Leu Leu Leu Ala Thr Arg Asp Leu Val Lys Ile Gly Asp Phe Gly
     290                 295                 300                
 Leu Met Arg Ala Leu Pro Gln Asn Asp Asp His Tyr Val Met Gln Glu
 305                 310                 315                 320
 His Arg Lys Val Pro Phe Ala Trp Cys Ala Pro Glu Ser Leu Lys Thr
                 325                 330                 335    
 Arg Thr Phe Ser His Ala Ser Asp Thr Trp Met Phe Gly Val Thr Leu
             340                 345                 350        
 Trp Glu Met Phe Thr Tyr Gly Gln Glu Pro Trp Ile Gly Leu Asn Gly
         355                 360                 365            
 Ser Gln Ile Leu His Lys Ile Asp Lys Glu Gly Glu Arg Leu Pro Arg
     370                 375                 380                
 Pro Glu Asp Cys Pro Gln Asp Ile Tyr Asn Val Met Val Gln Cys Trp
 385                 390                 395                 400
 Ala His Lys Pro Glu Asp Arg Pro Thr Phe Val Ala Leu Arg Asp Phe
                 405                 410                 415    
 Leu Leu Glu Ala Gln Pro Thr Asp Met Arg Ala Leu Gln Asp Phe Glu
             420                 425                 430        
 Glu Pro Asp Lys Leu His Ile Gln Met Asn Asp Val Ile Thr Val Ile
         435                 440                 445            
 Glu Gly Arg Ala Glu Asn Tyr Trp Trp Arg Gly Gln Asn Thr Arg Thr
     450                 455                 460                
 Leu Cys Val Gly Pro Phe Pro Arg Asn Val Val Thr Ser Val Ala Gly
 465                 470                 475                 480
 Leu Ser Ala Gln Asp Ile Ser Gln Pro Leu Gln Asn Ser Phe Ile His
                 485                 490                 495    
 Thr Gly His Gly Asp Ser Asp Pro Arg His Cys Trp Gly Phe Pro Asp
             500                 505                 510        
 Arg Ile Asp Glu Leu Tyr Leu Gly Asn Pro Met Asp Pro Pro Asp Leu
         515                 520                 525            
 Leu Ser Val Glu Leu Ser Thr Ser Arg Pro Pro Gln His Leu Gly Gly
     530                 535                 540                
 Val Lys Lys Pro Thr Tyr Asp Pro Val Ser Glu Asp Gln Asp Pro Leu
 545                 550                 555                 560
 Ser Ser Asp Phe Lys Arg Leu Gly Leu Arg Lys Pro Gly Leu Pro Arg
                 565                 570                 575    
 Gly Leu Trp Leu Ala Lys Pro Ser Ala Arg Val Pro Gly Thr Lys Ala
             580                 585                 590        
 Ser Arg Gly Ser Gly Ala Glu Val Thr Leu Ile Asp Phe Gly Glu Glu
         595                 600                 605            
 Pro Val Val Pro Ala Leu Arg Pro Cys Pro Pro Ser Leu Ala Gln Leu
     610                 615                 620                
 Ala Met Asp Ala Cys Ser Leu Leu Asp Glu Thr Pro Pro Gln Ser Pro
 625                 630                 635                 640
 Thr Arg Ala Leu Pro Arg Pro Leu His Pro Thr Pro Val Val Asp Trp
                 645                 650                 655    
 Asp Ala Arg Pro Leu Pro Pro Pro Pro Ala Tyr Asp Asp Val Ala Gln
             660                 665                 670        
 Asp Glu Asp Asp Phe Glu Ile Cys Ser Ile Asn Ser Thr Leu Val Gly
         675                 680                 685            
 Ala Gly Val Pro Ala Gly Pro Ser Gln Gly Gln Thr Asn Tyr Ala Phe
     690                 695                 700                
 Val Pro Glu Gln Ala Arg Pro Pro Pro Pro Leu Glu Asp Asn Leu Phe
 705                 710                 715                 720
 Leu Pro Pro Gln Gly Gly Gly Lys Pro Pro Ser Ser Ala Gln Thr Ala
                 725                 730                 735    
 Glu Ile Phe Gln Ala Leu Gln Gln Glu Cys Met Arg Gln Leu Gln Ala
             740                 745                 750        
 Pro Gly Ser Pro Ala Pro Ser Pro Ser Pro Gly Gly Asp Asp Lys Pro
         755                 760                 765            
 Gln Val Pro Pro Arg Val Pro Ile Pro Pro Arg Pro Thr Arg Pro His
     770                 775                 780                
 Val Gln Leu Ser Pro Ala Pro Pro Gly Glu Glu Glu Thr Ser Gln Trp
 785                 790                 795                 800
 Pro Gly Pro Ala Ser Pro Pro Arg Val Pro Pro Arg Glu Pro Leu Ser
                 805                 810                 815    
 Pro Gln Gly Ser Arg Thr Pro Ser Pro Leu Val Pro Pro Gly Ser Ser
             820                 825                 830        
 Pro Leu Pro Pro Arg Leu Ser Ser Ser Pro Gly Lys Thr Met Pro Thr
         835                 840                 845            
 Thr Gln Ser Phe Ala Ser Asp Pro Lys Tyr Ala Thr Pro Gln Val Ile
     850                 855                 860                
 Gln Ala Pro Gly Ala Gly Gly Pro Cys Ile Leu Pro Ile Val Arg Asp
 865                 870                 875                 880
 Gly Lys Lys Val Ser Ser Thr His Tyr Tyr Leu Leu Pro Glu Arg Pro
                 885                 890                 895    
 Ser Tyr Leu Glu Arg Tyr Gln Arg Phe Leu Arg Glu Ala Gln Ser Pro
             900                 905                 910        
 Glu Glu Pro Thr Pro Leu Pro Val Pro Leu Leu Leu Pro Pro Pro Ser
         915                 920                 925            
 Thr Pro Ala Pro Ala Ala Pro Thr Ala Thr Val Arg Pro Met Pro Gln
     930                 935                 940                
 Ala Ala Leu Asp Pro Lys Ala Asn Phe Ser Thr Asn Asn Ser Asn Pro
 945                 950                 955                 960
 Gly Ala Arg Pro Pro Pro Pro Arg Ala Thr Ala Arg Leu Pro Gln Arg
                 965                 970                 975    
 Gly Cys Pro Gly Asp Gly Pro Glu Ala Gly Arg Pro Ala Asp Lys Ile
             980                 985                 990        
 Gln Met Ala Met Val His Gly Val Thr Thr Glu Glu Cys Gln Ala Ala
         995                1000                1005            
 Leu Gln Cys His Gly Trp Ser Val Gln Arg Ala Ala Gln Tyr Leu Lys
    1010                1015                1020                
 Val Glu Gln Leu Phe Gly Leu Gly Leu Arg Pro Arg Gly Glu Cys His
1025                1030                1035                1040
 Lys Val Leu Glu Met Phe Asp Trp Asn Leu Glu Gln Ala Gly Cys His
                1045                1050                1055    
 Leu Leu Gly Ser Trp Gly Pro Ala His His Lys Arg
            1060                1065            



      <210> 1224
      <211> 316
      <212> PRT
      <213> Homo sapiens


      <400> 1224
 Met Gln Phe Pro Asn Val Lys Ile Phe Asp Met Leu Ser Ser Leu Phe
   1               5                  10                  15    
 Tyr Phe Tyr Leu Val Thr Gln Ser Asn Phe Trp Phe Thr Asp Val Cys
              20                  25                  30        
 Lys Pro Asp Ala Ser Cys Asp Gln Ala Arg Pro Pro Pro Val Gln Ser
          35                  40                  45            
 Tyr Met Asp Ala Ala Phe Leu Leu Asp Ala Ser Arg Asn Met Gly Ser
      50                  55                  60                
 Ala Glu Phe Glu Asp Ile Arg Ala Phe Leu Gly Ala Leu Leu Asp His
  65                  70                  75                  80
 Phe Glu Ile Thr Pro Glu Pro Glu Thr Ser Val Thr Gly Asp Arg Val
                  85                  90                  95    
 Ala Leu Leu Ser His Ala Pro Pro Asp Phe Leu Pro Asn Thr Gln Lys
             100                 105                 110        
 Ser Pro Val Arg Ala Glu Phe Asn Leu Thr Thr Tyr Arg Ser Lys Arg
         115                 120                 125            
 Leu Met Lys Arg His Val His Glu Ser Val Lys Gln Leu Asn Gly Asp
     130                 135                 140                
 Ala Phe Ile Gly His Ala Leu Gln Trp Thr Leu Asp Asn Val Phe Leu
 145                 150                 155                 160
 Ser Thr Pro Asn Leu Arg Arg Asn Lys Val Ile Phe Val Ile Ser Ala
                 165                 170                 175    
 Gly Glu Thr Ser His Leu Asp Gly Glu Ile Leu Lys Lys Glu Ser Leu
             180                 185                 190        
 Arg Ala Lys Cys Gln Gly Tyr Ala Leu Phe Val Phe Ser Leu Gly Pro
         195                 200                 205            
 Ile Trp Asp Asp Lys Glu Leu Glu Asp Leu Ala Ser His Pro Leu Asp
     210                 215                 220                
 His His Leu Val Gln Leu Gly Arg Ile His Lys Pro Asp His Ser Tyr
 225                 230                 235                 240
 Gly Val Lys Phe Val Lys Ser Phe Ile Asn Ser Ile Arg Arg Ala Ile
                 245                 250                 255    
 Asn Lys Tyr Pro Pro Ile Asn Leu Lys Ile Lys Cys Asn Arg Leu Asn
             260                 265                 270        
 Ser Ile Asp Pro Lys Gln Pro Pro Arg Pro Phe Arg Ser Phe Val Pro
         275                 280                 285            
 Gly Pro Leu Ile Ala Thr Leu Lys Glu Asp Val Leu Gln Lys Ala Lys
     290                 295                 300                
 Phe Phe Gln Asp Lys Lys Tyr Leu Ser Arg Val Ala
 305                 310                 315    



      <210> 1225
      <211> 405
      <212> PRT
      <213> Homo sapiens


      <400> 1225
 Met Glu Met Trp Leu Leu Ile Leu Val Ala Tyr Met Phe Gln Arg Asn
   1               5                  10                  15    
 Val Asn Ser Val His Met Pro Thr Lys Ala Val Asp Pro Glu Ala Phe
              20                  25                  30        
 Met Asn Ile Ser Glu Ile Ile Gln His Gln Gly Tyr Pro Cys Glu Glu
          35                  40                  45            
 Tyr Glu Val Ala Thr Glu Asp Gly Tyr Ile Leu Ser Val Asn Arg Ile
      50                  55                  60                
 Pro Arg Gly Leu Val Gln Pro Lys Lys Thr Gly Ser Arg Pro Val Val
  65                  70                  75                  80
 Leu Leu Gln His Gly Leu Val Gly Gly Ala Ser Asn Trp Ile Ser Asn
                  85                  90                  95    
 Leu Pro Asn Asn Ser Leu Gly Phe Ile Leu Ala Asp Ala Gly Phe Asp
             100                 105                 110        
 Val Trp Met Gly Asn Ser Arg Gly Asn Ala Trp Ser Arg Lys His Lys
         115                 120                 125            
 Thr Leu Ser Ile Asp Gln Asp Glu Phe Trp Ala Phe Ser Tyr Asp Glu
     130                 135                 140                
 Met Ala Arg Phe Asp Leu Pro Ala Val Ile Asn Phe Ile Leu Gln Lys
 145                 150                 155                 160
 Thr Gly Gln Glu Lys Ile Tyr Tyr Val Gly Tyr Ser Gln Gly Thr Thr
                 165                 170                 175    
 Met Gly Phe Ile Ala Phe Ser Thr Met Pro Glu Leu Ala Gln Lys Ile
             180                 185                 190        
 Lys Met Tyr Phe Ala Leu Ala Pro Ile Ala Thr Val Lys His Ala Lys
         195                 200                 205            
 Ser Pro Gly Thr Lys Phe Leu Leu Leu Pro Asp Met Met Ile Lys Gly
     210                 215                 220                
 Leu Phe Gly Lys Lys Glu Phe Leu Tyr Gln Thr Arg Phe Leu Arg Gln
 225                 230                 235                 240
 Leu Val Ile Tyr Leu Cys Gly Gln Val Ile Leu Asp Gln Ile Cys Ser
                 245                 250                 255    
 Asn Ile Met Leu Leu Leu Gly Gly Phe Asn Thr Asn Asn Met Asn Met
             260                 265                 270        
 Ser Arg Ala Ser Val Tyr Ala Ala His Thr Leu Ala Gly Thr Ser Val
         275                 280                 285            
 Gln Asn Ile Leu His Trp Ser Gln Ala Val Asn Ser Gly Glu Leu Arg
     290                 295                 300                
 Ala Phe Asp Trp Gly Ser Glu Thr Lys Asn Leu Glu Lys Cys Asn Gln
 305                 310                 315                 320
 Pro Thr Pro Val Arg Tyr Arg Val Arg Asp Met Thr Val Pro Thr Ala
                 325                 330                 335    
 Met Trp Thr Gly Gly Gln Asp Trp Leu Ser Asn Pro Arg Asp Val Lys
             340                 345                 350        
 Met Leu Leu Ser Glu Val Thr Asn Leu Ile Tyr His Lys Asn Ile Pro
         355                 360                 365            
 Glu Trp Ala His Val Asp Phe Ile Trp Gly Leu Asp Ala Pro His Arg
     370                 375                 380                
 Met Tyr Asn Glu Ile Ile His Leu Met Gln Gln Glu Glu Thr Gln Pro
 385                 390                 395                 400
 Phe Pro Arg Thr Ala
                 405



      <210> 1226
      <211> 91
      <212> PRT
      <213> Homo sapiens


      <400> 1226
 Met Val Pro Cys Ser Gly Leu Cys Pro Leu Val Gly Ser Trp Pro Phe
   1               5                  10                  15    
 Leu Tyr Ser Leu Gly Cys Ser Ser Trp Ala Lys Leu Ser Phe Leu Thr
              20                  25                  30        
 Cys Cys Leu Trp Val Asp Gly Ser Arg Pro Gly Pro Val Leu Ser Glu
          35                  40                  45            
 Pro Glu Leu Gln Ser Arg Leu Met Asp Phe Ala His Phe His Gln Lys
      50                  55                  60                
 Cys Gly Asn Leu Cys Thr Ser Asn Gln Phe His Val Gln Ile Thr Ala
  65                  70                  75                  80
 Leu Phe Trp Ser Glu Cys Tyr Phe Gly Gly Pro
                  85                  90    



      <210> 1227
      <211> 169
      <212> PRT
      <213> Homo sapiens


      <400> 1227
 Met Glu Leu Trp Gly Ala Tyr Leu Leu Leu Cys Leu Phe Ser Leu Leu
   1               5                  10                  15    
 Thr Gln Val Thr Thr Glu Pro Pro Thr Gln Lys Pro Lys Lys Ile Val
              20                  25                  30        
 Asn Ala Lys Lys Val Cys Leu Lys Gly Thr Lys Val His Met Lys Cys
          35                  40                  45            
 Phe Leu Ala Phe Thr Gln Thr Lys Thr Phe His Glu Ala Ser Glu Asp
      50                  55                  60                
 Cys Ile Ser Arg Gly Gly Thr Leu Ser Thr Pro Gln Thr Gly Ser Glu
  65                  70                  75                  80
 Asn Asp Ala Leu Tyr Glu Tyr Leu Arg Gln Ser Val Gly Asn Glu Ala
                  85                  90                  95    
 Glu Ile Trp Leu Gly Leu Asn Asp Met Ala Ala Glu Gly Thr Trp Val
             100                 105                 110        
 Asp Met Thr Gly Ala Arg Ile Ala Tyr Lys Asn Trp Glu Thr Glu Ile
         115                 120                 125            
 Thr Ala Gln Pro Asp Gly Gly Lys Thr Glu Asn Cys Ala Val Leu Ser
     130                 135                 140                
 Gly Ala Ala Asn Gly Lys Trp Phe Asp Lys Arg Cys Arg Asp Gln Leu
 145                 150                 155                 160
 Pro Tyr Ile Cys Gln Phe Gly Ile Val
                 165                



      <210> 1228
      <211> 54
      <212> PRT
      <213> Homo sapiens


      <400> 1228
 Met Trp Lys Ser Phe Thr Val Glu Val Phe Ser Phe Ile Trp Arg Thr
   1               5                  10                  15    
 Ile Val Gln Ile Ser Leu Ile Leu Leu Leu His Val Cys Phe Ser Thr
              20                  25                  30        
 Leu Ser Val Ser Ser Val Ser Arg Met Ala Gly Phe Tyr Cys Ile Ala
          35                  40                  45            
 Val Leu Phe Val Arg Phe
      50                



      <210> 1229
      <211> 97
      <212> PRT
      <213> Homo sapiens


      <400> 1229
 Met Asn Pro Pro Ala Leu Cys Ile Phe Ser Lys Thr Ala Leu Ala Ile
   1               5                  10                  15    
 Trp Gly Pro Leu Ile Phe His Met Asn Phe Gln Met Gly Phe Ser Val
              20                  25                  30        
 Ser Val Lys Asn Val Ile Gly Thr Leu Val Arg Gly Ala Leu His Pro
          35                  40                  45            
 Cys Ser Gly Asp His Phe Gly Trp Asp Cys His Leu Asn Ile Val Pro
      50                  55                  60                
 Ile His Glu His Glu Cys Leu Ser Val Gly Gly Leu Phe Lys Lys Lys
  65                  70                  75                  80
 Asn Ser Leu Cys Glu Asn Gly Pro Trp Ile Leu Ile Lys Ser Gln Ile
                  85                  90                  95    
 Ile
    



      <210> 1230
      <211> 76
      <212> PRT
      <213> Homo sapiens


      <400> 1230
 Met Pro Ala Val Ser Gly Pro Gly Pro Leu Phe Cys Leu Leu Leu Leu
   1               5                  10                  15    
 Leu Leu Asp Pro His Ser Pro Glu Thr Gly Cys Pro Pro Leu Arg Arg
              20                  25                  30        
 Phe Glu Tyr Lys Leu Ser Phe Lys Gly Pro Arg Leu Ala Leu Pro Gly
          35                  40                  45            
 Ala Gly Ile Pro Phe Trp Ser His His Gly Gly Leu Leu Ser Ser Pro
      50                  55                  60                
 Leu Pro Leu Leu Gly Pro Leu Pro Phe Leu Tyr Leu
  65                  70                  75    



      <210> 1231
      <211> 61
      <212> PRT
      <213> Homo sapiens


      <400> 1231
 Met Pro Val Met Ser Gln Leu Leu Ser Val His Ser Glu Pro Ser Leu
   1               5                  10                  15    
 Leu Phe Leu Leu Thr Phe Pro His Ser Cys Asn Pro Pro Ser Leu Pro
              20                  25                  30        
 Ser Ser Ser Leu Ser Leu Ser Leu Thr His Thr His Thr His Thr His
          35                  40                  45            
 Thr His Ser Thr His Thr His Ile Ser Arg Val Leu Gln
      50                  55                  60    



      <210> 1232
      <211> 56
      <212> PRT
      <213> Homo sapiens


      <400> 1232
 Met Gln Glu Ser Asn Ile Tyr Phe Leu Ser Ile Cys Phe Lys Thr Ser
   1               5                  10                  15    
 Trp Cys Leu Phe Leu Leu Ala Thr Gly His Leu Tyr Tyr Cys Asn Ser
              20                  25                  30        
 Gln Thr Leu Trp Gln Tyr Thr Glu His Cys Tyr Asp Ser Leu Phe Phe
          35                  40                  45            
 Asn Thr Phe Val Leu Ser Phe Ser
      50                  55    



      <210> 1233
      <211> 82
      <212> PRT
      <213> Homo sapiens


      <400> 1233
 Met Asn Val Thr Ala Ile Trp Leu His Arg Asp Lys Leu Phe Cys Trp
   1               5                  10                  15    
 Leu Val Ile Ser Tyr Ile Ser Glu Ile Cys Leu Ser Glu Cys Trp Ile
              20                  25                  30        
 Lys Ile Ala Val Phe Lys Asn Ser Leu Phe Lys Asn Val Leu Gln Tyr
          35                  40                  45            
 Tyr Ile Leu Thr Asp Leu Cys Leu Ser Gln Leu Leu Met Asn Asn Leu
      50                  55                  60                
 Tyr Ser Leu Glu Ser Tyr Ile Lys Gly Tyr Phe Ser Phe Cys Trp Gly
  65                  70                  75                  80
 Asp Gly
        



      <210> 1234
      <211> 73
      <212> PRT
      <213> Homo sapiens


      <400> 1234
 Met Leu Pro Thr Cys Phe Leu Ser Tyr Pro Phe Leu Leu Ile Phe Phe
   1               5                  10                  15    
 Leu Val Gln Leu Leu Tyr Ile Trp Thr Ser Leu Tyr Cys Pro Pro Phe
              20                  25                  30        
 Leu Ser Asn Leu Ser Leu Pro Tyr Ser Ser Ala Leu Ser Pro Leu Leu
          35                  40                  45            
 Ile Leu His Val Cys Pro Val Ala Ala His Leu Leu Phe Ser Ser Thr
      50                  55                  60                
 Thr Thr Tyr Met Pro Leu Ile Pro Leu
  65                  70            



      <210> 1235
      <211> 56
      <212> PRT
      <213> Homo sapiens


      <400> 1235
 Met Pro Val Pro Leu Ala Arg Ile Cys Trp Val Ser Phe Leu His Gln
   1               5                  10                  15    
 Ala Pro Cys Trp Glu Leu Cys Tyr Tyr Cys Val Val Leu Thr Ser Ala
              20                  25                  30        
 Leu Ile Gly Ala Val Asn Ser Ser Ile Leu Gln Met Thr Gly Ser Thr
          35                  40                  45            
 Gly Arg Leu Asp Ser Trp Pro Trp
      50                  55    



      <210> 1236
      <211> 70
      <212> PRT
      <213> Homo sapiens


      <400> 1236
 Met Val Leu Cys Ser Ser Ala Phe Leu Thr Val Gln Trp Gly Gly Glu
   1               5                  10                  15    
 Ala Ser Asp Asn Ile Tyr Leu Ala Phe Tyr Phe Ser Val Cys Gly Phe
              20                  25                  30        
 Thr Ile Ser Leu Thr Leu Thr Pro Ser Arg His Leu Lys Gly Cys Val
          35                  40                  45            
 Glu Ala Arg Leu Ser Glu Ser Gly Glu Gly Glu Lys Gly Trp Gln Glu
      50                  55                  60                
 Gly Leu Val Ser Gly Ala
  65                  70



      <210> 1237
      <211> 385
      <212> PRT
      <213> Homo sapiens


      <400> 1237
 Met Phe Thr Ile Lys Leu Leu Leu Phe Ile Val Pro Leu Val Ile Ser
   1               5                  10                  15    
 Ser Arg Ile Asp Gln Asp Asn Ser Ser Phe Asp Ser Leu Ser Pro Glu
              20                  25                  30        
 Pro Lys Ser Arg Phe Ala Met Leu Asp Asp Val Lys Ile Leu Ala Asn
          35                  40                  45            
 Gly Leu Leu Gln Leu Gly His Gly Leu Lys Asp Phe Val His Lys Thr
      50                  55                  60                
 Lys Gly Gln Ile Asn Asp Ile Phe Gln Lys Leu Asn Ile Phe Asp Gln
  65                  70                  75                  80
 Ser Phe Tyr Asp Leu Ser Leu Gln Thr Ser Glu Ile Lys Glu Glu Glu
                  85                  90                  95    
 Lys Glu Leu Arg Arg Thr Thr Tyr Lys Leu Gln Val Lys Asn Glu Glu
             100                 105                 110        
 Val Lys Asn Met Ser Leu Glu Leu Asn Ser Lys Leu Glu Ser Leu Leu
         115                 120                 125            
 Glu Glu Lys Ile Leu Leu Gln Gln Lys Val Lys Tyr Leu Glu Glu Gln
     130                 135                 140                
 Leu Thr Asn Leu Ile Gln Asn Gln Pro Glu Thr Pro Glu His Pro Glu
 145                 150                 155                 160
 Val Thr Ser Leu Lys Thr Phe Val Glu Lys Gln Asp Asn Ser Ile Lys
                 165                 170                 175    
 Asp Leu Leu Gln Thr Val Glu Asp Gln Tyr Lys Gln Leu Asn Gln Gln
             180                 185                 190        
 His Ser Gln Ile Lys Glu Ile Glu Asn Gln Leu Arg Arg Thr Ser Ile
         195                 200                 205            
 Gln Glu Pro Thr Glu Ile Ser Leu Ser Ser Lys Pro Arg Ala Pro Arg
     210                 215                 220                
 Thr Thr Pro Phe Leu Gln Leu Asn Glu Ile Arg Asn Val Lys His Asp
 225                 230                 235                 240
 Gly Ile Pro Ala Glu Cys Thr Thr Ile Tyr Asn Arg Gly Glu His Thr
                 245                 250                 255    
 Ser Gly Met Tyr Ala Ile Arg Pro Ser Asn Ser Gln Val Phe His Val
             260                 265                 270        
 Tyr Cys Asp Val Ile Ser Gly Ser Pro Trp Thr Leu Ile Gln His Arg
         275                 280                 285            
 Ile Asp Gly Ser Arg Glu Ile Trp Met Gly Leu Glu Lys Ile Tyr Ser
     290                 295                 300                
 Ile Val Lys Gln Ser Asn Tyr Val Leu Arg Ile Glu Leu Glu Asp Trp
 305                 310                 315                 320
 Lys Asp Asn Lys His Tyr Ile Glu Tyr Ser Phe Tyr Leu Gly Asn His
                 325                 330                 335    
 Glu Thr Asn Tyr Thr Leu His Leu Val Ala Ile Thr Gly Asn Val Pro
             340                 345                 350        
 Asn Ala Ile Pro Glu Asn Lys Asp Leu Val Phe Ser Thr Trp Asp His
         355                 360                 365            
 Lys Ala Lys Gly His Phe Asn Cys Pro Glu Gly Tyr Ser Gly Ile Phe
     370                 375                 380                
 Phe
 385



      <210> 1238
      <211> 53
      <212> PRT
      <213> Homo sapiens


      <400> 1238
 Met Glu Ile Thr Lys Ser Trp Phe Val Phe Leu Trp Leu Ile Lys Phe
   1               5                  10                  15    
 Leu Glu Asn Arg Asp Thr Tyr Val Ser Phe Phe Ala Asp Leu Lys Lys
              20                  25                  30        
 Ile Val Arg Glu Ile Arg Gly Val Ile Ile Ile Ser Ser Ala Leu Ala
          35                  40                  45            
 Arg Ile Met Arg Asn
      50            



      <210> 1239
      <211> 45
      <212> PRT
      <213> Homo sapiens


      <400> 1239
 Met Ser Val Phe Phe Leu Ser Cys Leu Ile Leu Pro Gln Pro Gly Pro
   1               5                  10                  15    
 Ile Ala Ala Gly Val Arg Cys Tyr Ser Trp Thr Pro Pro Leu Val Arg
              20                  25                  30        
 Gly Asp Leu Ala Gly Lys Val Ala Cys Asp Val His Pro
          35                  40                  45



      <210> 1240
      <211> 71
      <212> PRT
      <213> Homo sapiens


      <400> 1240
 Met Tyr Thr His Phe Phe Ser Ile Trp Leu Leu Gly Ile Leu Thr Lys
   1               5                  10                  15    
 Ile Glu Asn Cys Pro Phe Ser Val Arg Tyr Gly Ile Ser Cys His Thr
              20                  25                  30        
 Asp Phe Leu Arg Leu Tyr Ile Gln Leu Cys Leu Glu Val Pro Ile Phe
          35                  40                  45            
 Ala Gln Trp Ile Glu Tyr Ile Leu Phe Ala Ile Tyr Gln Lys Arg His
      50                  55                  60                
 Val Leu Pro Thr Tyr Val Arg
  65                  70    



      <210> 1241
      <211> 48
      <212> PRT
      <213> Homo sapiens


      <400> 1241
 Met His Cys Thr Phe Leu Ser Val Leu Ala Leu Pro Val Ile Val Arg
   1               5                  10                  15    
 Ile Leu Lys Ser Trp Ser Ser Cys Leu Trp Glu Gly Asn Leu Val His
              20                  25                  30        
 Val Lys Cys Leu Lys Phe Pro Val Pro Cys Pro Thr Asn Asn Val Glu
          35                  40                  45            





      <210> 1242
      <211> 45
      <212> PRT
      <213> Homo sapiens


      <400> 1242
 Met His Cys Thr Phe Leu Ser Val Leu Ala Leu Pro Val Ile Val Arg
   1               5                  10                  15    
 Ile Leu Lys Ser Trp Ser Ser Cys Leu Trp Glu Gly Asn Leu Val His
              20                  25                  30        
 Val Lys Cys Leu Lys Phe Pro Val Leu Ser His Gly Ser
          35                  40                  45



      <210> 1243
      <211> 47
      <212> PRT
      <213> Homo sapiens


      <400> 1243
 Met His Val Leu Phe Thr Leu Tyr Leu Val Pro Cys Cys Leu His Phe
   1               5                  10                  15    
 Glu Leu Phe Ile Gly Asp Leu Ala Val Lys Asn Gly Thr Lys His Ser
              20                  25                  30        
 Ala Glu Val Leu Ser Arg Val Pro Lys His Lys Lys Ala Val Arg
          35                  40                  45        



      <210> 1244
      <211> 62
      <212> PRT
      <213> Homo sapiens


      <400> 1244
 Met Lys Cys Phe Leu Phe Val Cys Leu Phe Val Cys Phe Ser Glu Lys
   1               5                  10                  15    
 Leu Asp Leu Gly Ala Ser Phe Phe Ser Leu Ser Ala Pro Leu Ala Phe
              20                  25                  30        
 Gly Val Arg Phe Ser Trp Ser Cys Leu Pro Arg Asn Ser Ala Val His
          35                  40                  45            
 Val Leu Val Met Arg Asp Thr Lys Ala Asn Met Pro Cys Ser
      50                  55                  60        



      <210> 1245
      <211> 71
      <212> PRT
      <213> Homo sapiens


      <400> 1245
 Met Gly Arg Leu Phe Pro Leu Val Leu Leu Leu Phe Pro Val Thr Asn
   1               5                  10                  15    
 Ser Val Ser Pro Thr Ala Leu Leu Val Leu Val Thr Thr Gly Gly Ser
              20                  25                  30        
 Gly Pro Ala Thr Met Val Leu Leu Pro Ala Pro Val Met Gly Arg Ile
          35                  40                  45            
 Pro Asn His Cys Leu Ser Lys Ser Ser Arg Gln Ser Pro Ser Pro Arg
      50                  55                  60                
 Cys Asp Lys Pro Glu Val Pro
  65                  70    



      <210> 1246
      <211> 63
      <212> PRT
      <213> Homo sapiens


      <400> 1246
 Met Thr Ala Gln His His Ser Ile Ala Val Leu Leu Leu Asn Leu Glu
   1               5                  10                  15    
 Val Thr Cys Glu Cys Met Glu Tyr Asn Lys Val Phe Tyr Ser Gly Ser
              20                  25                  30        
 Phe Ala Ser Thr Ser Phe Leu Ile Gly Tyr Cys Ser Ser Ser Ser Gly
          35                  40                  45            
 Phe Tyr Phe Val Gln Arg Gln Gly Pro Asn Phe Ala Asn Val Val
      50                  55                  60            



      <210> 1247
      <211> 510
      <212> PRT
      <213> Homo sapiens


      <400> 1247
 Met Leu Leu Leu Ser Cys Gln Ala Arg Leu Val Met Tyr Ile Glu Arg
   1               5                  10                  15    
 Asp Ser Arg Lys Thr Thr Pro Gly Lys Glu Gln Gln Ser Gly Asn Glu
              20                  25                  30        
 Tyr Leu Ser Lys Cys Leu Asp Leu Leu Ile Cys His Ile Val Gln Glu
          35                  40                  45            
 Leu Pro Arg Ile Leu Gly Asp Ile Leu Asn Ser Leu Ala Asn Val Ser
      50                  55                  60                
 Gly Arg Lys His Pro Ser Thr Val Gln Val Lys Gln Leu Lys Leu Cys
  65                  70                  75                  80
 Leu Pro Leu Met Pro Val Val Leu His Leu Val Thr Ser Gln Val Phe
                  85                  90                  95    
 Arg Pro Gln Val Val Thr Glu Glu Phe Leu Phe Ser Tyr Gly Thr Ile
             100                 105                 110        
 Leu Ser His Ile Lys Ser Val Asp Ser Gly Glu Thr Asn Ile Asp Gly
         115                 120                 125            
 Ala Ile Gly Leu Thr Ala Ser Glu Glu Phe Ile Lys Ile Thr Leu Ser
     130                 135                 140                
 Ala Phe Glu Ala Ile Ile Gln Tyr Pro Ile Leu Leu Lys Asp Tyr Arg
 145                 150                 155                 160
 Ser Thr Val Val Asp Tyr Ile Leu Pro Pro Leu Val Ser Leu Val Gln
                 165                 170                 175    
 Ser Gln Asn Val Glu Trp Arg Leu Phe Ser Leu Arg Leu Leu Ser Glu
             180                 185                 190        
 Thr Thr Ser Leu Leu Val Asn Gln Glu Phe Gly Asp Gly Lys Glu Lys
         195                 200                 205            
 Ala Ser Val Asp Ser Asp Ser Asn Leu Leu Ala Leu Ile Arg Asp Val
     210                 215                 220                
 Leu Leu Pro Gln Tyr Glu His Ile Leu Leu Glu Pro Asp Pro Val Pro
 225                 230                 235                 240
 Ala Tyr Ala Leu Lys Leu Leu Val Ala Met Thr Glu His Asn Pro Thr
                 245                 250                 255    
 Phe Thr Arg Leu Val Glu Glu Ser Lys Leu Ile Pro Leu Ile Phe Glu
             260                 265                 270        
 Val Thr Leu Glu His Gln Glu Ser Ile Leu Gly Asn Thr Met Gln Ser
         275                 280                 285            
 Val Ile Ala Leu Leu Ser Asn Leu Val Ala Cys Lys Asp Ser Asn Met
     290                 295                 300                
 Glu Leu Leu Tyr Glu Gln Gly Leu Val Ser His Ile Cys Asn Leu Leu
 305                 310                 315                 320
 Thr Glu Thr Ala Thr Leu Cys Leu Asp Val Asp Asn Lys Asn Asn Asn
                 325                 330                 335    
 Glu Met Ala Ala Pro Leu Leu Phe Ser Leu Leu Asp Ile Leu His Ser
             340                 345                 350        
 Met Leu Thr Tyr Thr Ser Gly Ile Val Arg Leu Ala Leu Gln Ala Gln
         355                 360                 365            
 Lys Ser Gly Ser Gly Glu Asp Pro Gln Ala Ala Glu Asp Leu Leu Leu
     370                 375                 380                
 Leu Asn Arg Pro Leu Thr Asp Leu Ile Ser Leu Leu Ile Pro Leu Leu
 385                 390                 395                 400
 Pro Asn Glu Asp Pro Glu Ile Phe Asp Val Ser Ser Lys Cys Leu Ser
                 405                 410                 415    
 Ile Leu Val Gln Leu Tyr Gly Gly Glu Asn Pro Asp Ser Leu Ser Pro
             420                 425                 430        
 Glu Asn Val Glu Ile Phe Ala His Leu Leu Thr Ser Lys Glu Asp Pro
         435                 440                 445            
 Lys Glu Gln Lys Leu Leu Leu Arg Ile Leu Arg Arg Met Ile Thr Ser
     450                 455                 460                
 Asn Glu Lys His Leu Glu Ser Leu Lys Asn Ala Gly Ser Leu Leu Arg
 465                 470                 475                 480
 Ala Leu Glu Arg Leu Ala Pro Gly Ser Gly Ser Phe Ala Asp Ser Ala
                 485                 490                 495    
 Val Ala Pro Leu Ala Leu Glu Ile Leu Gln Ala Val Gly His
             500                 505                 510



      <210> 1248
      <211> 95
      <212> PRT
      <213> Homo sapiens


      <400> 1248
 Met Val Ala Ser Phe Arg Glu Ser Arg Val Leu Leu Leu Gly Phe Val
   1               5                  10                  15    
 Val Arg Val Leu Thr Phe Asp Phe Leu Thr Gln Val Val Arg Val Gly
              20                  25                  30        
 Ser Glu Cys Gly Asp Glu Leu Val Arg Leu Tyr Ser Phe Thr Asp Glu
          35                  40                  45            
 Lys Ala Asn Tyr Leu Gln Gln Gly Gly Cys Arg Cys Gly Pro Arg Gly
      50                  55                  60                
 Thr Leu Trp Gly Ile Gly Arg Pro Arg Gly Glu Pro Ser Ser Ser Ser
  65                  70                  75                  80
 Pro Gly Gln Ser Pro Gly His Phe His Gly Trp Leu Ala Ser Ser
                  85                  90                  95



      <210> 1249
      <211> 48
      <212> PRT
      <213> Homo sapiens


      <400> 1249
 Met Ser Glu Phe Leu Cys Phe Phe Thr Gln Arg Ala Ile Val Thr Thr
   1               5                  10                  15    
 Phe Ser Leu Ser Thr Thr Glu Gly Asn Ser Cys Ala Thr Trp Leu Cys
              20                  25                  30        
 Val Pro Phe Pro Gly Cys Ser Val Leu Trp Ser Val Leu Asp Arg Lys
          35                  40                  45            





      <210> 1250
      <211> 46
      <212> PRT
      <213> Homo sapiens


      <400> 1250
 Met Gly Phe Leu Cys Glu Ile Gly Ala Ile Pro Thr Met Val Leu Ala
   1               5                  10                  15    
 Leu Trp Gly Phe Leu Arg Ala Ser Ser Ala Ser Pro Pro Ser Leu Asn
              20                  25                  30        
 Arg Leu Pro Gly Gln Gly Ser Ala Phe Ser Phe Gln Ile Cys
          35                  40                  45    



      <210> 1251
      <211> 57
      <212> PRT
      <213> Homo sapiens


      <400> 1251
 Met Phe Ile Phe Lys Thr Lys Gly Ile Leu Leu Pro Cys Gln Lys Met
   1               5                  10                  15    
 Leu Gln Ile Val Phe Phe Phe Leu Pro Lys Asn Thr Leu Ser Ser Met
              20                  25                  30        
 Phe Tyr Phe Ser Asp Cys Ile Gly Val His Lys Tyr Met His Ile Leu
          35                  40                  45            
 Ile Tyr Ile His Thr Tyr Val Ser Leu
      50                  55        



      <210> 1252
      <211> 56
      <212> PRT
      <213> Homo sapiens


      <400> 1252
 Met His Leu Phe Phe His Thr Leu Thr Ser Leu Arg Leu Gly Cys Ile
   1               5                  10                  15    
 Ile Gln Ser Leu Leu Ala Arg Gly Ala Ser Cys Cys Tyr Cys His His
              20                  25                  30        
 Met Asn Ile Arg Ile Cys Glu Trp Met Ser Ala Ala Gln Lys Glu Ile
          35                  40                  45            
 Pro Glu Ile Val Val Glu His Pro
      50                  55    



      <210> 1253
      <211> 43
      <212> PRT
      <213> Homo sapiens


      <400> 1253
 Met Ile Thr Gln Leu Gly Glu Thr Leu Leu Leu Gln Tyr Leu Thr Thr
   1               5                  10                  15    
 Cys Thr Ile Gln Gln Ile Ser Ser Thr Thr Lys Ser Gln Gln Met Val
              20                  25                  30        
 Gln Leu Val Phe Asn Glu Gln Lys Ala Phe Val
          35                  40            



      <210> 1254
      <211> 57
      <212> PRT
      <213> Homo sapiens


      <400> 1254
 Met Cys Leu Arg Arg Thr Leu Leu Trp His Leu His Ile Ala Pro Leu
   1               5                  10                  15    
 Val Asn Ile Leu Ser Asp Tyr Lys Pro Leu Gly Arg Trp Asn His Ala
              20                  25                  30        
 Pro Ala Leu Thr Ala Gly Ala Leu His Lys Thr Thr Ile Leu Leu Pro
          35                  40                  45            
 Gln Gly His Pro Lys Ala Ala Asn Pro
      50                  55        



      <210> 1255
      <211> 54
      <212> PRT
      <213> Homo sapiens


      <400> 1255
 Met Leu Val Phe Asn Leu Ser Leu Val Leu Ser His Ser Val Leu Glu
   1               5                  10                  15    
 Phe Val Met Phe Leu Tyr Ser Leu Asp Ser Ser His Val Cys Pro Leu
              20                  25                  30        
 Val Val Pro Val Thr Leu Asp Leu Ile Tyr Leu Val Tyr Leu Pro Cys
          35                  40                  45            
 Gln Ser Tyr Ile Leu Ile
      50                



      <210> 1256
      <211> 50
      <212> PRT
      <213> Homo sapiens


      <400> 1256
 Met Ser Leu Asn Pro Glu Phe Leu Trp Leu Lys Trp Phe Ser Leu Leu
   1               5                  10                  15    
 Leu Arg Gly Arg Arg Asn Ser Cys Leu Ile Ala Leu Lys Gly Tyr His
              20                  25                  30        
 Ser Val Met Ile Phe His Leu Pro Leu Ile Pro Ser Ser Val Thr Ser
          35                  40                  45            
 Cys His
      50



      <210> 1257
      <211> 581
      <212> PRT
      <213> Homo sapiens


      <400> 1257
 Met Pro Leu Lys His Tyr Leu Leu Leu Leu Val Gly Cys Gln Ala Trp
   1               5                  10                  15    
 Gly Ala Gly Leu Ala Tyr His Gly Cys Pro Ser Glu Cys Thr Cys Ser
              20                  25                  30        
 Arg Ala Ser Gln Val Glu Cys Thr Gly Ala Arg Ile Val Ala Val Pro
          35                  40                  45            
 Thr Pro Leu Pro Trp Asn Ala Met Ser Leu Gln Ile Leu Asn Thr His
      50                  55                  60                
 Ile Thr Glu Leu Asn Glu Ser Pro Phe Leu Asn Ile Ser Ala Leu Ile
  65                  70                  75                  80
 Ala Leu Arg Ile Glu Lys Asn Glu Leu Ser Arg Ile Thr Pro Gly Ala
                  85                  90                  95    
 Phe Arg Asn Leu Gly Ser Leu Arg Tyr Leu Ser Leu Ala Asn Asn Lys
             100                 105                 110        
 Leu Gln Val Leu Pro Ile Gly Leu Phe Gln Gly Leu Asp Ser Leu Glu
         115                 120                 125            
 Ser Leu Leu Leu Ser Ser Asn Gln Leu Leu Gln Ile Gln Pro Ala His
     130                 135                 140                
 Phe Ser Gln Cys Ser Asn Leu Lys Glu Leu Gln Leu His Gly Asn His
 145                 150                 155                 160
 Leu Glu Tyr Ile Pro Asp Gly Ala Phe Asp His Leu Val Gly Leu Thr
                 165                 170                 175    
 Lys Leu Asn Leu Gly Lys Asn Ser Leu Thr His Ile Ser Pro Arg Val
             180                 185                 190        
 Phe Gln His Leu Gly Asn Leu Gln Val Leu Arg Leu Tyr Glu Asn Arg
         195                 200                 205            
 Leu Thr Asp Ile Pro Met Gly Thr Phe Asp Gly Leu Val Asn Leu Gln
     210                 215                 220                
 Glu Leu Ala Leu Gln Gln Asn Gln Ile Gly Leu Leu Ser Pro Gly Leu
 225                 230                 235                 240
 Phe His Asn Asn His Asn Leu Gln Arg Leu Tyr Leu Ser Asn Asn His
                 245                 250                 255    
 Ile Ser Gln Leu Pro Pro Ser Ile Phe Met Gln Leu Pro Gln Leu Asn
             260                 265                 270        
 Arg Leu Thr Leu Phe Gly Asn Ser Leu Lys Glu Leu Ser Leu Gly Ile
         275                 280                 285            
 Phe Gly Pro Met Pro Asn Leu Arg Glu Leu Trp Leu Tyr Asp Asn His
     290                 295                 300                
 Ile Ser Ser Leu Pro Asp Asn Val Phe Ser Asn Leu Arg Gln Leu Gln
 305                 310                 315                 320
 Val Leu Ile Leu Ser Arg Asn Gln Ile Ser Phe Ile Ser Pro Gly Ala
                 325                 330                 335    
 Phe Asn Gly Leu Thr Glu Leu Arg Glu Leu Ser Leu His Thr Asn Ala
             340                 345                 350        
 Leu Gln Asp Leu Asp Gly Asn Val Phe Arg Met Leu Ala Asn Leu Gln
         355                 360                 365            
 Asn Ile Ser Leu Gln Asn Asn Arg Leu Arg Gln Leu Pro Gly Asn Ile
     370                 375                 380                
 Phe Ala Asn Val Asn Gly Leu Met Ala Ile Gln Leu Gln Asn Asn Gln
 385                 390                 395                 400
 Leu Glu Asn Leu Pro Leu Gly Ile Phe Asp His Leu Gly Lys Leu Cys
                 405                 410                 415    
 Glu Leu Arg Leu Tyr Asp Asn Pro Trp Arg Cys Asp Ser Asp Ile Leu
             420                 425                 430        
 Pro Leu Arg Asn Trp Leu Leu Leu Asn Gln Pro Arg Leu Gly Thr Asp
         435                 440                 445            
 Thr Val Pro Val Cys Phe Ser Pro Ala Asn Val Arg Gly Gln Ser Leu
     450                 455                 460                
 Ile Ile Ile Asn Val Asn Val Ala Val Pro Ser Val His Val Pro Glu
 465                 470                 475                 480
 Val Pro Ser Tyr Pro Glu Thr Pro Trp Tyr Pro Asp Thr Pro Ser Tyr
                 485                 490                 495    
 Pro Asp Thr Thr Ser Val Ser Ser Thr Thr Glu Leu Thr Ser Pro Val
             500                 505                 510        
 Glu Asp Tyr Thr Asp Leu Thr Thr Ile Gln Val Thr Asp Asp Arg Ser
         515                 520                 525            
 Val Trp Gly Met Thr His Ala His Ser Gly Leu Ala Ile Ala Ala Ile
     530                 535                 540                
 Val Ile Gly Ile Val Ala Leu Ala Cys Ser Leu Ala Ala Cys Val Gly
 545                 550                 555                 560
 Cys Cys Cys Cys Lys Lys Arg Ser Gln Ala Val Leu Met Gln Met Lys
                 565                 570                 575    
 Ala Pro Asn Glu Cys
             580    



      <210> 1258
      <211> 83
      <212> PRT
      <213> Homo sapiens


      <400> 1258
 Met Gly Leu Asn Ile Pro Gly Leu Trp Ser Leu Ser Ser Val Leu Ser
   1               5                  10                  15    
 Leu Thr Gly Leu Thr Ser Pro Val Val Phe Leu Gly Ser Arg Glu Gln
              20                  25                  30        
 Asn Pro Leu Ala Lys Arg Leu Ala Leu Lys Glu Leu Leu Pro Phe Thr
          35                  40                  45            
 His Ser Gln Gln Ser Ser Ser Glu Leu Pro Leu Arg Pro Pro Arg Ala
      50                  55                  60                
 Ala Arg Arg Pro Cys Gln Pro Asn Ser Val Gly Gly Thr Gly His Ala
  65                  70                  75                  80
 Ala Arg Cys
            



      <210> 1259
      <211> 92
      <212> PRT
      <213> Homo sapiens


      <400> 1259
 Met Glu Ala Glu Thr Pro Cys Thr Ile Phe Thr Phe Ser Pro Ser Leu
   1               5                  10                  15    
 Lys Tyr Arg Phe Trp Leu Leu Leu Leu Phe Ser Met Ala Ser Ser Glu
              20                  25                  30        
 Pro Met Pro Gln Tyr Phe Leu Ser Cys Thr Leu Ser Glu Lys Lys Tyr
          35                  40                  45            
 Ser Pro Leu Gly Leu Arg Gly Gly Gly Gln Gln Gly Ala His His His
      50                  55                  60                
 Cys Gly Gly Ser Lys Gly Gln Gly Leu Asp His Val Pro His Gly Leu
  65                  70                  75                  80
 Asp Ala Thr Ser Ala Met Met Asp Thr Pro Lys Cys
                  85                  90        



      <210> 1260
      <211> 35
      <212> PRT
      <213> Homo sapiens


      <400> 1260
 Met Lys Pro Phe Thr Val Leu Lys Gly Phe His Phe Ser Val Phe Cys
   1               5                  10                  15    
 Leu Leu Pro Leu Ile Thr His Asn Ile Asn Leu Gln Thr Thr Trp Gln
              20                  25                  30        
 Ile Arg Val
          35



      <210> 1261
      <211> 195
      <212> PRT
      <213> Homo sapiens


      <400> 1261
 Met Gly Ser Trp His Trp Glu Trp Tyr Gly Ala Pro Thr Ser Thr Leu
   1               5                  10                  15    
 Ser Leu Gly Cys Leu Leu Leu Pro Gly Glu Lys Trp Thr Phe Leu Ile
              20                  25                  30        
 Leu Pro Ser His Tyr Gly Thr Thr Thr His Ala His Ser Leu Gln Gly
          35                  40                  45            
 Cys Val Glu Arg Gln Trp Gln Asp Ser Lys Gln Leu Ala Ile Ser Pro
      50                  55                  60                
 Gly Pro Thr Leu Leu Arg Ser Glu Tyr Val Gly Ser Leu Ser Pro Val
  65                  70                  75                  80
 Cys Ser Ser Leu Thr Gln Val His Arg Val Pro Trp Gly Gln His Arg
                  85                  90                  95    
 Ala Cys Pro Val Met Leu Leu Val Phe Thr Lys Trp Leu Gln Arg Tyr
             100                 105                 110        
 Leu His Phe Glu Lys Pro Ala Glu Pro Ala Ser Val Gly Gln Asp Pro
         115                 120                 125            
 Asp Phe Phe Gly Lys Ser Glu Gly Glu Arg Ala Thr Cys Leu Leu Ser
     130                 135                 140                
 Arg Ser Cys Leu Tyr Leu Ala Ser Val Cys Asn Leu Arg Glu Asn Asp
 145                 150                 155                 160
 Ser Cys Met Gly Arg Ser Gly Gly Thr Gly Lys Ser Asp Leu Pro Gly
                 165                 170                 175    
 Ser Trp Arg Trp Trp Asn Leu Ser Ile Ser Pro Val Asp Gly Leu Ser
             180                 185                 190        
 Thr Asp Leu
         195



      <210> 1262
      <211> 297
      <212> PRT
      <213> Homo sapiens


      <400> 1262
 Met Val Gln Asp Ala Gly Ser Cys Gly Ser Leu Ala Pro Pro Arg Pro
   1               5                  10                  15    
 Leu Val Leu Leu Leu Leu Thr Arg Phe Ala Gln Ala Ala Ser Ser Asp
              20                  25                  30        
 Gly Trp Gly Leu Cys Tyr Pro Gln His Gln Ala Thr Ser Val Gly Ala
          35                  40                  45            
 His Gly Gln Ala Arg Gln Leu Gly Pro Trp Val Trp Pro Trp Pro Asp
      50                  55                  60                
 Ala Pro Ser Thr Gly Ser Arg Leu Leu Leu Leu Leu Leu Ser Ser Met
  65                  70                  75                  80
 Asp Ser Leu Asp Cys Met Val Gly Val Ser Asp Val Ser Leu Phe Gly
                  85                  90                  95    
 Gly Gln Arg Trp Gly Leu Lys Val Leu Ala Glu Leu Arg Leu Gly Leu
             100                 105                 110        
 Ser Val Gly Pro Glu Val Ala Leu Leu Arg Glu Leu Val Gly His Gly
         115                 120                 125            
 Gly Arg Arg Asn Asp Gly Phe Glu Ala Ala Leu Ala Leu Gly His Val
     130                 135                 140                
 Leu Leu Arg Val Glu Glu Asp Asp Val Asp Phe Gly His Val Glu His
 145                 150                 155                 160
 Ser Gln Gly His Arg Gly Ala Gln Thr His Arg Asp Arg Gln Arg Arg
                 165                 170                 175    
 Arg Leu Asp Val Gln Leu Val Gly Arg Leu Arg Gly Ala Lys Glu Asp
             180                 185                 190        
 Gly Asp Glu Gly Gln Pro Asp Asp Ala Ser Gly Val His Gly Glu Ala
         195                 200                 205            
 Asn Gly Leu Gly Leu Ile Glu Gly Leu Gly His Ala Ala Cys Leu Asp
     210                 215                 220                
 Gly Ile His Gly Ala Arg Asp His Glu Gln His Ala Val Ala Gln Gln
 225                 230                 235                 240
 Ala Asp Glu Arg Gln Val Arg Asp Val Thr Leu Glu His Thr Pro Gly
                 245                 250                 255    
 Glu Ala Gly Val Glu Cys Pro Leu Val Leu Glu Val His His Arg Val
             260                 265                 270        
 Gly Gly Val His His Lys Pro His Thr Asp Ala Gln Gln Leu Gln Arg
         275                 280                 285            
 Asp Glu Ala Glu Gly Asp Gly Gln Leu
     290                 295        



      <210> 1263
      <211> 769
      <212> PRT
      <213> Homo sapiens


      <400> 1263
 Met Gly Pro Ala Trp Val Gln Asp Pro Leu Thr Gly Ala Leu Trp Leu
   1               5                  10                  15    
 Pro Val Leu Trp Ala Leu Leu Ser Gln Val Tyr Cys Phe His Asp Pro
              20                  25                  30        
 Pro Gly Trp Arg Phe Thr Ser Ser Glu Ile Val Ile Pro Arg Lys Val
          35                  40                  45            
 Pro His Lys Arg Gly Gly Val Glu Met Pro Asp Gln Leu Ser Tyr Ser
      50                  55                  60                
 Met Arg Phe Arg Gly Gln Arg His Val Ile His Met Lys Leu Lys Lys
  65                  70                  75                  80
 Asn Met Met Pro Arg His Leu Pro Val Phe Thr Asp Asn Asp Gln Gly
                  85                  90                  95    
 Ala Met Gln Glu Asn Tyr Pro Phe Val Pro Arg Asp Cys Tyr Tyr Asp
             100                 105                 110        
 Cys Tyr Leu Glu Gly Val Pro Gly Ser Ala Ala Thr Leu Asp Thr Cys
         115                 120                 125            
 Arg Gly Gly Leu His Gly Met Leu Gln Val Asp Asp Leu Thr Tyr Glu
     130                 135                 140                
 Ile Lys His Leu Glu Ala Ser Ser Lys Phe Glu His Val Val Ser Leu
 145                 150                 155                 160
 Leu Val Ser Glu Glu Arg Pro Gly Glu Ala Ser Arg Cys Lys Thr Glu
                 165                 170                 175    
 Gly Glu Glu Ile Asp Gln Glu Ser Glu Lys Val Lys Leu Ala Glu Thr
             180                 185                 190        
 Pro Arg Ala Gly His Val Tyr Leu Trp Arg His His Arg Lys Asn Leu
         195                 200                 205            
 Lys Ile His Tyr Thr Val Thr Arg Gly Leu Phe Met Arg Asn Pro Asn
     210                 215                 220                
 Val Ser His Ile Ile Glu Asn Val Val Ile Ile Asn Ser Ile Ile His
 225                 230                 235                 240
 Thr Ile Phe Lys Pro Val Tyr Leu Asn Val Tyr Ile Cys Val Leu Cys
                 245                 250                 255    
 Ile Trp Asn Gln Lys Asp Ala Val Leu Phe Ser Ala Ser Arg Pro Gly
             260                 265                 270        
 His Val Ala Val Glu Leu Phe Gly Val Trp Lys Tyr His Asn Leu Tyr
         275                 280                 285            
 Ser Glu Ile Ser His Asp Thr Ser Val Val Phe Thr Ser Asn Arg Leu
     290                 295                 300                
 Gly Asn Ser Glu Cys Tyr Ala Ser Phe Asp Gly Ile Cys Thr Pro Asn
 305                 310                 315                 320
 Trp Gly Ala Met Phe Val Tyr Ile Met Arg Tyr His Leu Phe Arg Gly
                 325                 330                 335    
 Ala Cys Val Thr Ala His Ala Leu Gly His Asn Met Gly Leu Arg His
             340                 345                 350        
 Asp Ser Val Gly Cys Tyr Cys Phe Arg Arg Thr Asn Cys Leu Met Thr
         355                 360                 365            
 Arg Val Pro Asp Leu Asn Asp Met Met Ser Asn Cys Ser Tyr Glu Ile
     370                 375                 380                
 Ile Gln Arg Lys Phe Asn Gln Trp Asp Pro Cys Leu Ser Ala Pro Asn
 385                 390                 395                 400
 Val Pro Tyr Thr Asn Phe Pro Tyr Val Ala Pro Arg Cys Gly Asp Lys
                 405                 410                 415    
 Ile Lys Asn Gln Arg Glu Glu Cys Asp Cys Gly Ser Leu Lys Asp Cys
             420                 425                 430        
 Ala Ser Asp Arg Cys Cys Glu Thr Ser Cys Thr Leu Ser Leu Gly Ser
         435                 440                 445            
 Val Cys Asn Thr Gly Leu Cys Cys His Lys Cys Lys Tyr Ala Ala Pro
     450                 455                 460                
 Gly Val Val Cys Arg Asp Leu Gly Gly Ile Cys Asp Leu Pro Glu Tyr
 465                 470                 475                 480
 Cys Asp Gly Lys Lys Glu Glu Cys Pro Asn Asp Ile Tyr Ile Gln Asp
                 485                 490                 495    
 Gly Thr Pro Cys Ser Ala Val Ser Val Cys Ile Arg Gly Asn Cys Ser
             500                 505                 510        
 Asp Arg Asp Met Gln Cys Gln Ala Leu Phe Gly Tyr Gln Val Lys Asp
         515                 520                 525            
 Gly Ser Pro Ala Cys Tyr Arg Lys Leu Asn Arg Ile Gly Asn Arg Phe
     530                 535                 540                
 Gly Asn Cys Gly Val Ile Leu Arg Arg Gly Gly Ser Arg Pro Phe Pro
 545                 550                 555                 560
 Cys Glu Glu Asp Asp Val Phe Cys Gly Met Leu His Cys Ser Gly Val
                 565                 570                 575    
 Ser His Ile Pro Gly Gly Val His Asp Ile Lys Glu Glu Lys Cys Phe
             580                 585                 590        
 Gly Tyr Glu Ala His Gln Gly Thr Asp Leu Pro Glu Met Gly Leu Val
         595                 600                 605            
 Val Asp Gly Ala Thr Cys Gly Pro Gly Ser Tyr Cys Leu Lys Arg Asn
     610                 615                 620                
 Cys Thr Phe Tyr Gln Asp Leu His Phe Glu Cys Asp Leu Lys Thr Cys
 625                 630                 635                 640
 Asn Tyr Lys Gly Val Cys Asn Asn Lys Lys His Cys His Cys Leu His
                 645                 650                 655    
 Glu Trp Gln Pro Pro Thr Cys Glu Leu Arg Gly Lys Gly Gly Ser Ile
             660                 665                 670        
 Asp Ser Gly Pro Leu Pro Asp Lys Gln Tyr Arg Ile Ala Gly Ser Ile
         675                 680                 685            
 Leu Thr Glu Val Lys Gly Ile Ile Gln Leu Asn Tyr Met Arg Glu Tyr
     690                 695                 700                
 Leu Lys Thr Ser Ser Lys Ala Trp Glu Asn Gly Ser Gln His Gly Lys
 705                 710                 715                 720
 Glu Leu Arg Ile Val Thr Tyr Lys Trp Ile Phe Tyr Lys Ile Ser Phe
                 725                 730                 735    
 Ser Thr Leu Val Tyr His Tyr Phe Ile Asn Glu Gly Ala Gln Val Tyr
             740                 745                 750        
 Asn Leu Ala Gly Ile Glu Gly Gly Val Pro Gly Gly Lys Val Leu Gly
         755                 760                 765            
 Ile
    



      <210> 1264
      <211> 440
      <212> PRT
      <213> Homo sapiens


      <400> 1264
 Met Ser Ser Cys Arg Gly Gln Lys Val Ala Gly Gly Leu Arg Val Val
   1               5                  10                  15    
 Ser Pro Phe Pro Leu Cys Gln Pro Ala Gly Glu Pro Ser Arg Gly Lys
              20                  25                  30        
 Met Arg Ser Ser Cys Val Leu Leu Thr Ala Leu Val Ala Leu Ala Ala
          35                  40                  45            
 Tyr Tyr Val Tyr Ile Pro Leu Pro Gly Ser Val Ser Asp Pro Trp Lys
      50                  55                  60                
 Leu Met Leu Leu Asp Ala Thr Phe Arg Gly Ala Gln Gln Val Ser Asn
  65                  70                  75                  80
 Leu Ile His Tyr Leu Gly Leu Ser His His Leu Leu Ala Leu Asn Phe
                  85                  90                  95    
 Ile Ile Val Ser Phe Gly Lys Lys Ser Ala Trp Ser Ser Ala Gln Val
             100                 105                 110        
 Lys Val Thr Asp Thr Asp Phe Asp Gly Val Glu Val Arg Val Phe Glu
         115                 120                 125            
 Gly Pro Pro Lys Pro Glu Glu Pro Leu Lys Arg Ser Val Val Tyr Ile
     130                 135                 140                
 His Gly Gly Gly Trp Ala Leu Ala Ser Ala Lys Ile Arg Tyr Tyr Asp
 145                 150                 155                 160
 Glu Leu Cys Thr Ala Met Ala Glu Glu Leu Asn Ala Val Ile Val Ser
                 165                 170                 175    
 Ile Glu Tyr Arg Leu Val Pro Lys Val Tyr Phe Pro Glu Gln Ile His
             180                 185                 190        
 Asp Val Val Arg Ala Thr Lys Tyr Phe Leu Lys Pro Glu Val Leu Gln
         195                 200                 205            
 Lys Tyr Met Val Asp Pro Gly Arg Ile Cys Ile Ser Gly Asp Ser Ala
     210                 215                 220                
 Gly Gly Asn Leu Ala Ala Ala Leu Gly Gln Gln Phe Thr Gln Asp Ala
 225                 230                 235                 240
 Ser Leu Lys Asn Lys Leu Lys Leu Gln Ala Leu Ile Tyr Pro Val Leu
                 245                 250                 255    
 Gln Ala Leu Asp Phe Asn Thr Pro Ser Tyr Gln Gln Asn Val Asn Thr
             260                 265                 270        
 Pro Ile Leu Pro Arg Tyr Val Met Val Lys Tyr Trp Val Asp Tyr Phe
         275                 280                 285            
 Lys Gly Asn Tyr Asp Phe Val Gln Ala Met Ile Val Asn Asn His Thr
     290                 295                 300                
 Ser Leu Asp Val Glu Glu Ala Ala Ala Val Arg Ala Arg Leu Asn Trp
 305                 310                 315                 320
 Thr Ser Leu Leu Pro Ala Ser Phe Thr Lys Asn Tyr Lys Pro Val Val
                 325                 330                 335    
 Gln Thr Thr Gly Asn Ala Arg Ile Val Gln Glu Leu Pro Gln Leu Leu
             340                 345                 350        
 Asp Ala Arg Ser Ala Pro Leu Ile Ala Asp Gln Ala Val Leu Gln Leu
         355                 360                 365            
 Leu Pro Lys Thr Tyr Ile Leu Thr Cys Glu His Asp Val Leu Arg Asp
     370                 375                 380                
 Asp Gly Ile Met Tyr Ala Lys Arg Leu Glu Ser Ala Gly Val Glu Val
 385                 390                 395                 400
 Thr Leu Asp His Phe Glu Asp Gly Phe His Gly Cys Met Ile Phe Thr
                 405                 410                 415    
 Ser Trp Pro Thr Asn Phe Ser Val Gly Ile Arg Thr Arg Asn Ser Tyr
             420                 425                 430        
 Ile Lys Trp Leu Asp Gln Asn Leu
         435                 440



      <210> 1265
      <211> 48
      <212> PRT
      <213> Homo sapiens


      <400> 1265
 Met Thr His Leu Leu Phe Val Arg Phe Cys Phe Leu Gln Pro Phe Tyr
   1               5                  10                  15    
 Ala Tyr Lys Ala Asn Leu Phe Cys Ser Ala His Glu Asn Thr Leu Phe
              20                  25                  30        
 Tyr Lys Met Arg Cys Cys Leu Ile Leu Glu Ser Gln Ile Lys Thr Asn
          35                  40                  45            





      <210> 1266
      <211> 394
      <212> PRT
      <213> Homo sapiens


      <400> 1266
 Met Met Lys Thr Leu Leu Leu Phe Val Gly Leu Leu Leu Thr Trp Glu
   1               5                  10                  15    
 Ser Gly Gln Val Leu Gly Asp Gln Thr Val Ser Asp Asn Glu Leu Gln
              20                  25                  30        
 Glu Met Ser Asn Gln Gly Ser Lys Tyr Val Asn Lys Glu Ile Gln Asn
          35                  40                  45            
 Ala Val Asn Gly Val Lys Gln Ile Lys Thr Leu Ile Glu Lys Thr Asn
      50                  55                  60                
 Glu Glu Arg Lys Thr Leu Leu Ser Asn Leu Glu Glu Ala Lys Lys Lys
  65                  70                  75                  80
 Lys Glu Asp Ala Leu Asn Glu Thr Arg Asn Gln Ser Ser Pro Phe Tyr
                  85                  90                  95    
 Phe Trp Met Asn Gly Asp Arg Ile Asp Ser Leu Leu Glu Asn Asp Arg
             100                 105                 110        
 Gln Gln Thr His Met Leu Asp Val Met Gln Asp His Phe Ser Arg Ala
         115                 120                 125            
 Ser Ser Ile Ile Asp Glu Leu Phe Gln Asp Arg Phe Phe Thr Arg Glu
     130                 135                 140                
 Pro Gln Asp Thr Tyr His Tyr Leu Pro Phe Ser Leu Pro His Arg Arg
 145                 150                 155                 160
 Pro His Phe Phe Phe Pro Lys Ser Arg Ile Val Arg Ser Leu Met Pro
                 165                 170                 175    
 Phe Ser Pro Tyr Glu Pro Leu Asn Phe His Ala Met Phe Gln Pro Phe
             180                 185                 190        
 Leu Glu Met Ile His Glu Ala Gln Gln Ala Met Asp Ile His Phe His
         195                 200                 205            
 Ser Pro Ala Phe Gln His Pro Pro Thr Glu Phe Ile Arg Glu Gly Asp
     210                 215                 220                
 Asp Asp Arg Thr Val Cys Arg Glu Ile Arg His Asn Ser Thr Gly Cys
 225                 230                 235                 240
 Leu Arg Met Lys Asp Gln Cys Asp Lys Cys Arg Glu Ile Leu Ser Val
                 245                 250                 255    
 Asp Cys Ser Thr Asn Asn Pro Ser Gln Ala Lys Leu Arg Arg Glu Leu
             260                 265                 270        
 Asp Glu Ser Leu Gln Val Ala Glu Arg Leu Thr Arg Lys Tyr Asn Glu
         275                 280                 285            
 Leu Leu Lys Ser Tyr Gln Trp Lys Met Leu Asn Thr Ser Ser Leu Leu
     290                 295                 300                
 Glu Gln Leu Asn Glu Gln Phe Asn Trp Val Ser Arg Leu Ala Asn Leu
 305                 310                 315                 320
 Thr Gln Gly Glu Asp Gln Tyr Tyr Leu Arg Val Thr Thr Val Ala Ser
                 325                 330                 335    
 His Thr Ser Asp Ser Asp Val Pro Ser Gly Val Thr Glu Val Val Val
             340                 345                 350        
 Lys Leu Phe Asp Ser Asp Pro Ile Thr Val Thr Val Pro Val Glu Val
         355                 360                 365            
 Ser Arg Lys Asn Pro Lys Phe Met Glu Thr Val Ala Glu Lys Ala Leu
     370                 375                 380                
 Gln Glu Tyr Arg Lys Lys His Arg Glu Glu
 385                 390                



      <210> 1267
      <211> 428
      <212> PRT
      <213> Homo sapiens


      <400> 1267
 Met Tyr Ser Asn Val Ile Gly Thr Val Thr Ser Gly Lys Arg Lys Val
   1               5                  10                  15    
 Tyr Leu Leu Ser Leu Leu Leu Ile Gly Phe Trp Asp Cys Val Thr Cys
              20                  25                  30        
 His Gly Ser Pro Val Asp Ile Cys Thr Ala Lys Pro Arg Asp Ile Pro
          35                  40                  45            
 Met Asn Pro Met Cys Ile Tyr Arg Ser Pro Glu Lys Lys Ala Thr Glu
      50                  55                  60                
 Asp Glu Gly Ser Glu Gln Lys Ile Pro Glu Ala Thr Asn Arg Arg Val
  65                  70                  75                  80
 Trp Glu Leu Ser Lys Ala Asn Ser Arg Phe Ala Thr Thr Phe Tyr Gln
                  85                  90                  95    
 His Leu Ala Asp Ser Lys Asn Asp Asn Asp Asn Ile Phe Leu Ser Pro
             100                 105                 110        
 Leu Ser Ile Ser Thr Ala Phe Ala Met Thr Lys Leu Gly Ala Cys Asn
         115                 120                 125            
 Asp Thr Leu Gln Gln Leu Met Glu Val Phe Lys Phe Asp Thr Ile Ser
     130                 135                 140                
 Glu Lys Thr Ser Asp Gln Ile His Phe Phe Phe Ala Lys Leu Asn Cys
 145                 150                 155                 160
 Arg Leu Tyr Arg Ser Leu Thr Phe Asn Glu Thr Tyr Gln Asp Ile Ser
                 165                 170                 175    
 Glu Leu Val Tyr Gly Ala Lys Leu Gln Pro Leu Asp Phe Lys Glu Gly
             180                 185                 190        
 Arg Ile Thr Asp Val Ile Pro Ser Glu Ala Ile Asn Glu Leu Thr Val
         195                 200                 205            
 Leu Val Leu Val Asn Thr Ile Tyr Phe Lys Gly Leu Trp Lys Ser Lys
     210                 215                 220                
 Phe Ser Pro Glu Asn Thr Arg Lys Glu Leu Phe Tyr Lys Ala Asp Gly
 225                 230                 235                 240
 Glu Ser Cys Ser Ala Ser Met Met Tyr Gln Glu Gly Lys Phe Arg Tyr
                 245                 250                 255    
 Arg Arg Val Ala Glu Ser Thr Gln Val Leu Glu Leu Pro Phe Lys Gly
             260                 265                 270        
 Asp Asp Ile Thr Met Val Leu Ile Leu Pro Lys Pro Glu Lys Ser Pro
         275                 280                 285            
 Ala Lys Val Glu Lys Glu Leu Thr Pro Glu Val Leu Gln Glu Trp Leu
     290                 295                 300                
 Asp Glu Leu Glu Glu Met Met Leu Val Val His Met Pro Arg Phe Arg
 305                 310                 315                 320
 Ile Glu Asp Gly Phe Ser Leu Lys Glu Gln Leu Gln Asp Met Gly Leu
                 325                 330                 335    
 Val Asp Leu Phe Ser Pro Glu Lys Ser Lys Leu Pro Gly Ile Val Ala
             340                 345                 350        
 Glu Gly Arg Asp Asp Leu Tyr Val Ser Asp Ala Phe His Lys Ala Phe
         355                 360                 365            
 Leu Glu Val Asn Glu Glu Gly Ser Glu Ala Ala Ala Ser Thr Ala Val
     370                 375                 380                
 Val Ile Ala Gly Arg Ser Leu Asn Pro Asn Arg Val Thr Phe Lys Ala
 385                 390                 395                 400
 Asn Met Pro Phe Leu Val Phe Ile Arg Glu Val Pro Leu Asn Thr Ile
                 405                 410                 415    
 Ile Phe Met Gly Arg Val Ala Asn Pro Cys Val Lys
             420                 425            



      <210> 1268
      <211> 464
      <212> PRT
      <213> Homo sapiens


      <400> 1268
 Met Pro Gln Ile Thr Leu Ser Pro Leu Ala Gln Pro Cys Gly Arg Leu
   1               5                  10                  15    
 Ala Ala Met Tyr Ser Asn Val Ile Gly Thr Val Thr Ser Gly Lys Arg
              20                  25                  30        
 Lys Val Tyr Leu Leu Ser Leu Leu Leu Ile Gly Phe Trp Asp Cys Val
          35                  40                  45            
 Thr Cys His Gly Ser Pro Val Asp Ile Cys Thr Ala Lys Pro Arg Asp
      50                  55                  60                
 Ile Pro Met Asn Pro Met Cys Ile Tyr Arg Ser Pro Glu Lys Lys Ala
  65                  70                  75                  80
 Thr Glu Asp Glu Gly Ser Glu Gln Lys Ile Pro Glu Ala Thr Asn Arg
                  85                  90                  95    
 Arg Val Trp Glu Leu Ser Lys Ala Asn Ser Arg Phe Ala Thr Thr Phe
             100                 105                 110        
 Tyr Gln His Leu Ala Asp Ser Lys Asn Asp Asn Asp Asn Ile Phe Leu
         115                 120                 125            
 Ser Pro Leu Ser Ile Ser Thr Ala Phe Ala Met Thr Lys Leu Gly Ala
     130                 135                 140                
 Cys Asn Asp Thr Leu Gln Gln Leu Met Glu Val Phe Lys Phe Asp Thr
 145                 150                 155                 160
 Ile Ser Glu Lys Thr Ser Asp Gln Ile His Phe Phe Phe Ala Lys Leu
                 165                 170                 175    
 Asn Cys Arg Leu Tyr Arg Ser Leu Thr Phe Asn Glu Thr Tyr Gln Asp
             180                 185                 190        
 Ile Ser Glu Leu Val Tyr Gly Ala Lys Leu Gln Pro Leu Asp Phe Lys
         195                 200                 205            
 Glu Asn Ala Glu Gln Ser Arg Ala Ala Ile Asn Lys Trp Val Ser Asn
     210                 215                 220                
 Lys Thr Glu Gly Arg Ile Thr Asp Val Ile Pro Ser Glu Ala Ile Asn
 225                 230                 235                 240
 Glu Leu Thr Val Leu Val Leu Val Asn Thr Ile Tyr Phe Lys Gly Leu
                 245                 250                 255    
 Trp Lys Ser Lys Phe Ser Pro Glu Asn Thr Arg Lys Glu Leu Phe Tyr
             260                 265                 270        
 Lys Ala Asp Gly Glu Ser Cys Ser Ala Ser Met Met Tyr Gln Glu Gly
         275                 280                 285            
 Lys Phe Arg Tyr Arg Arg Val Ala Glu Gly Thr Gln Val Leu Glu Leu
     290                 295                 300                
 Pro Phe Lys Gly Asp Asp Ile Thr Met Val Leu Ile Leu Pro Lys Pro
 305                 310                 315                 320
 Glu Lys Ser Leu Ala Lys Val Glu Lys Glu Leu Thr Pro Glu Val Leu
                 325                 330                 335    
 Gln Glu Trp Leu Asp Glu Leu Glu Glu Met Met Leu Val Val His Met
             340                 345                 350        
 Pro Arg Phe Arg Ile Glu Asp Gly Phe Ser Leu Lys Glu Gln Leu Gln
         355                 360                 365            
 Asp Met Gly Leu Val Asp Leu Phe Ser Pro Glu Lys Ser Lys Leu Pro
     370                 375                 380                
 Gly Ile Val Ala Glu Gly Arg Asp Asp Leu Tyr Val Ser Asp Ala Phe
 385                 390                 395                 400
 His Lys Ala Phe Leu Glu Val Asn Glu Glu Gly Ser Glu Ala Ala Ala
                 405                 410                 415    
 Ser Thr Ala Val Val Ile Ala Gly Arg Ser Leu Asn Pro Asn Arg Val
             420                 425                 430        
 Thr Phe Lys Ala Asn Arg Pro Phe Leu Val Phe Ile Arg Glu Val Pro
         435                 440                 445            
 Leu Asn Thr Ile Ile Phe Met Gly Arg Val Ala Asn Pro Cys Val Lys
     450                 455                 460                





      <210> 1269
      <211> 75
      <212> PRT
      <213> Homo sapiens


      <400> 1269
 Met Ala Ser His Ala Leu Thr Lys Pro Arg Met His Gly Leu Leu Ala
   1               5                  10                  15    
 Glu His Leu Gln Phe His Ile Val Gly Val Phe Met Val Ser Leu Glu
              20                  25                  30        
 Leu Ala Val Phe Cys Lys Phe Ala Val Ala Glu Pro Arg Lys Lys Val
          35                  40                  45            
 Tyr Thr Asp Phe Phe Arg Asn Tyr Asp Ser Met Lys Asp Ile Glu Glu
      50                  55                  60                
 Met Arg Lys Ala Gly Ile Phe Gln Ser Thr Lys
  65                  70                  75



      <210> 1270
      <211> 134
      <212> PRT
      <213> Homo sapiens


      <400> 1270
 Met Trp Gly Pro Cys Ser Leu Ser Val Gln His Leu Trp Leu Trp Gln
   1               5                  10                  15    
 Thr Trp Ser Asp Val Glu Gly Gln Arg Pro Ala Leu Leu Ile Cys Thr
              20                  25                  30        
 Ala Ala Ala Gly Pro Thr Gln Gly Val Lys Ala Tyr Pro Asp Ala Thr
          35                  40                  45            
 Met His Arg Gln Leu Leu Ala Pro Val Glu Gly Arg Met Ala Glu Thr
      50                  55                  60                
 Leu Asn Gln Lys Leu His Val Ala Asn Val Leu Glu Asp Asp Pro Gly
  65                  70                  75                  80
 Tyr Leu Pro His Val Tyr Ser Glu Glu Gly Glu Cys Gly Gly Ala Pro
                  85                  90                  95    
 Ser Leu Ser Ser Leu Ala Ser Leu Glu Gln Glu Leu Gln Pro Asp Leu
             100                 105                 110        
 Leu Asp Ser Leu Gly Ser Lys Ala Thr Leu Phe Glu Glu Ile Tyr Ser
         115                 120                 125            
 Glu Ser Gly Val Pro Ser
     130                



      <210> 1271
      <211> 459
      <212> PRT
      <213> Homo sapiens


      <400> 1271
 Met Thr Leu Met Leu Gln Arg Arg Gln Leu Trp Phe Lys Ser Pro Gly
   1               5                  10                  15    
 Gly Trp Leu Cys Gly Asp Ala Ala Gly Arg Val Tyr Leu Lys Trp Lys
              20                  25                  30        
 His Cys Glu Thr Pro Gly Val Lys Thr Leu Cys Asn Leu Lys His Cys
          35                  40                  45            
 Glu Thr Pro Gly Val Lys Thr Leu Cys Asn Leu Lys Lys Leu Leu Asn
      50                  55                  60                
 Arg Leu Gln Lys Asp His Arg Glu Asp Val Tyr Leu Tyr Ile Ser Gly
  65                  70                  75                  80
 His Leu Asn Pro Asn Lys Leu Tyr Gln Pro Pro Glu Thr Ile Leu Gln
                  85                  90                  95    
 His Trp Pro Asn Ala His Arg Pro Lys Gly Glu Arg Ala Ser Glu Val
             100                 105                 110        
 Gly Glu Pro Pro Ala Gly Lys Val Ala Arg Met Lys Glu Ala Leu Ala
         115                 120                 125            
 His Phe Thr Ile His Thr Ala Leu Val Pro Ser Glu Ala Gln Asp Thr
     130                 135                 140                
 Pro Leu Phe Arg Tyr Leu Asn Pro Gln Ala Ser Leu Ser His Thr Ser
 145                 150                 155                 160
 Glu Glu Asp Phe Leu Pro Val Glu Ala Val Arg Glu Gly Lys Glu Glu
                 165                 170                 175    
 Lys Lys Gly Gly Pro Pro Gly Arg Gly Pro Pro Gly Trp Arg Arg Arg
             180                 185                 190        
 Glu Glu Leu Arg Leu Pro Asp Leu Lys Val Leu Cys Tyr Gln Glu Ala
         195                 200                 205            
 Gly Ser Arg Gly Thr Arg Asp Arg His His Tyr Val Ser Ser Tyr Leu
     210                 215                 220                
 Ala Gly Ala Thr Ser Ala Asp Arg Tyr Arg Met Phe Leu Arg Phe Gln
 225                 230                 235                 240
 Lys Glu Val Leu Ala Lys Gln Asp Leu Leu Lys Asn Asp Phe Thr Gly
                 245                 250                 255    
 Ser Lys Ala Ala Ala Gly His Glu Arg Lys Leu Gln Gln Glu Leu Gln
             260                 265                 270        
 Lys Met Cys Thr Cys Ser Pro Gln Gln Phe Asn Arg Leu His Val Phe
         275                 280                 285            
 Gly Lys Val Phe Glu Asp Ile Cys Asn Ser Ser Leu Ile Phe Gly Asp
     290                 295                 300                
 Leu Leu Lys Lys Val Lys Ala Leu Leu Ala Gln Leu Lys Ala Leu Gly
 305                 310                 315                 320
 Gln Arg Pro Val Lys Thr Ala Asp Met Asp Leu Ala Arg Glu Glu Leu
                 325                 330                 335    
 Arg Met Leu Val Thr Ala Thr Lys Ala Ala Leu Glu Gln Asn Asp Arg
             340                 345                 350        
 Leu Arg Ser Glu Leu Glu Met Glu Val Ala Leu Leu Gln Ser Ala Lys
         355                 360                 365            
 Glu Arg Ser Glu Ser Ser Glu Lys His Ile Ile Asp Glu Asn Arg Leu
     370                 375                 380                
 Thr Leu Thr Glu Lys Val Glu Lys Lys Arg Cys Glu Ile Leu Ser Lys
 385                 390                 395                 400
 Trp Asp Glu Ile Gln Ala Leu Glu Lys Glu Ile Lys Thr Thr Leu Val
                 405                 410                 415    
 His Thr Gly Ile Ser Asp Ile Thr Glu Asn Arg Ile Lys Ser Ile Glu
             420                 425                 430        
 His Glu Ala Ile Gln Leu Glu Thr Glu Asn Met Ile Leu Lys Lys Asn
         435                 440                 445            
 Ile Lys Leu Leu Lys Thr Cys Glu Gln Ile Ile
     450                 455                



      <210> 1272
      <211> 479
      <212> PRT
      <213> Homo sapiens


      <400> 1272
 Met Thr Leu Met Leu Gln Arg Arg Gln Leu Trp Phe Lys Ser Pro Gly
   1               5                  10                  15    
 Gly Trp Leu Cys Gly Asp Ala Ala Gly Arg Val Tyr Leu Lys Trp Lys
              20                  25                  30        
 His Cys Glu Thr Pro Gly Val Lys Thr Leu Cys Asn Leu Lys His Cys
          35                  40                  45            
 Glu Thr Pro Gly Val Lys Thr Leu Cys Asn Leu Lys Lys Leu Leu Asn
      50                  55                  60                
 Arg Leu Gln Lys Asp His Arg Glu Asp Val Tyr Leu Tyr Ile Ser Gly
  65                  70                  75                  80
 His Leu Asn Pro Asn Lys Leu Tyr Gln Pro Pro Glu Thr Ile Leu Gln
                  85                  90                  95    
 His Trp Pro Asn Ala His Arg Pro Lys Gly Glu Arg Ala Ser Glu Val
             100                 105                 110        
 Gly Glu Pro Pro Ala Gly Lys Val Ala Arg Met Lys Glu Ala Leu Ala
         115                 120                 125            
 His Phe Thr Ile His Thr Ala Leu Val Pro Ser Glu Ala Gln Asp Thr
     130                 135                 140                
 Pro Leu Phe Arg Tyr Leu Asn Pro Gln Ala Ser Leu Ser His Thr Ser
 145                 150                 155                 160
 Glu Glu Asp Phe Leu Pro Val Glu Ala Val Arg Glu Gly Lys Glu Glu
                 165                 170                 175    
 Lys Lys Gly Gly Pro Pro Gly Arg Gly Pro Pro Gly Trp Arg Arg Arg
             180                 185                 190        
 Glu Glu Leu Arg Leu Pro Asp Leu Lys Val Leu Cys Tyr Gln Glu Ala
         195                 200                 205            
 Gly Ser Arg Gly Thr Arg Asp Arg His His Tyr Val Ser Ser Tyr Leu
     210                 215                 220                
 Ala Gly Ala Thr Ser Ala Asp Arg Tyr Arg Met Phe Leu Arg Phe Gln
 225                 230                 235                 240
 Lys Glu Val Leu Ala Lys Gln Asp Leu Leu Lys Asn Asp Phe Thr Gly
                 245                 250                 255    
 Ser Lys Ala Ala Ala Gly His Glu Arg Lys Leu Gln Gln Glu Leu Gln
             260                 265                 270        
 Lys Met Cys Thr Cys Ser Pro Gln Gln Phe Asn Arg Leu His Val Phe
         275                 280                 285            
 Gly Lys Val Phe Glu Asp Ile Cys Asn Ser Ser Leu Ile Phe Gly Asp
     290                 295                 300                
 Leu Leu Lys Lys Val Lys Asp Glu Tyr Glu Leu Tyr Met Ala Thr Leu
 305                 310                 315                 320
 Leu Glu Ser Gln Pro Ala Ala Gln Tyr Glu Ala Leu Leu Ala Gln Leu
                 325                 330                 335    
 Lys Ala Leu Gly Gln Arg Pro Val Lys Thr Ala Asp Met Asp Leu Ala
             340                 345                 350        
 Arg Glu Glu Leu Arg Met Leu Val Thr Ala Thr Lys Ala Ala Leu Glu
         355                 360                 365            
 Gln Asn Asp Arg Leu Arg Ser Glu Leu Glu Met Glu Val Ala Leu Leu
     370                 375                 380                
 Gln Ser Ala Lys Glu Arg Ser Glu Ser Ser Glu Lys His Ile Ile Asp
 385                 390                 395                 400
 Glu Asn Arg Leu Thr Leu Thr Glu Lys Val Glu Lys Lys Arg Cys Glu
                 405                 410                 415    
 Ile Leu Ser Lys Trp Asp Glu Ile Gln Ala Leu Glu Lys Glu Ile Lys
             420                 425                 430        
 Thr Thr Leu Val His Thr Gly Ile Ser Asp Ile Thr Glu Asn Arg Ile
         435                 440                 445            
 Lys Ser Ile Glu His Glu Ala Ile Gln Leu Glu Thr Glu Asn Met Ile
     450                 455                 460                
 Leu Lys Lys Asn Ile Lys Leu Leu Lys Thr Cys Glu Gln Ile Ile
 465                 470                 475                



      <210> 1273
      <211> 281
      <212> PRT
      <213> Homo sapiens


      <400> 1273
 Met Ala Ser Pro Gln Leu Cys Arg Ala Leu Val Ser Ala Gln Trp Val
   1               5                  10                  15    
 Ala Glu Ala Leu Arg Ala Pro Arg Ala Gly Gln Pro Leu Gln Leu Leu
              20                  25                  30        
 Asp Ala Ser Trp Tyr Leu Pro Lys Leu Gly Arg Asp Ala Arg Arg Glu
          35                  40                  45            
 Phe Glu Glu Arg His Ile Pro Gly Ala Ala Phe Phe Asp Ile Asp Gln
      50                  55                  60                
 Cys Ser Asp Arg Thr Ser Pro Tyr Asp His Met Leu Pro Gly Ala Glu
  65                  70                  75                  80
 His Phe Ala Glu Tyr Ala Gly Arg Leu Gly Val Gly Ala Ala Thr His
                  85                  90                  95    
 Val Val Ile Tyr Asp Ala Ser Asp Gln Gly Leu Tyr Ser Ala Pro Arg
             100                 105                 110        
 Val Trp Trp Met Phe Arg Ala Phe Gly His His Ala Val Ser Leu Leu
         115                 120                 125            
 Asp Gly Gly Leu Arg His Trp Leu Arg Gln Asn Leu Pro Leu Ser Ser
     130                 135                 140                
 Gly Lys Ser Gln Pro Ala Pro Ala Glu Phe Arg Ala Gln Leu Asp Pro
 145                 150                 155                 160
 Ala Phe Ile Lys Thr Tyr Glu Asp Ile Lys Glu Asn Leu Glu Ser Arg
                 165                 170                 175    
 Arg Phe Gln Val Val Asp Ser Arg Ala Thr Gly Arg Phe Arg Gly Thr
             180                 185                 190        
 Glu Pro Glu Pro Arg Asp Asp Phe Leu Ser Gln Glu Gly Leu Glu Lys
         195                 200                 205            
 Ser Pro Glu Glu Ile Arg His Leu Phe Gln Glu Lys Lys Val Asp Leu
     210                 215                 220                
 Ser Lys Pro Leu Val Ala Thr Cys Gly Ser Gly Val Thr Ala Cys His
 225                 230                 235                 240
 Val Ala Leu Gly Ala Tyr Leu Cys Gly Lys Pro Asp Val Pro Ile Tyr
                 245                 250                 255    
 Asp Gly Ser Trp Val Glu Trp Tyr Met Arg Ala Arg Pro Glu Asp Val
             260                 265                 270        
 Ile Ser Glu Gly Arg Gly Lys Thr His
         275                 280    



      <210> 1274
      <211> 404
      <212> PRT
      <213> Homo sapiens


      <400> 1274
 Met Tyr Val Gly Leu Leu Asn Ile Leu Val Ser Leu Ser Gly Lys Val
   1               5                  10                  15    
 Pro Phe Trp Leu Tyr Leu Gly Ser Arg Leu Ala Thr Pro Pro Thr Ser
              20                  25                  30        
 Ser Gln Leu Phe Phe Ile Gly Gly Lys Glu Arg Ser Pro Asp Glu Gln
          35                  40                  45            
 Gly Val Asp Ile Leu Ile Val Leu Ile Phe Arg Tyr Pro Ser Thr Asp
      50                  55                  60                
 Ser Ala Glu Gln Ile Lys Lys Lys Ile Glu Lys Ala Leu Tyr Gln Ser
  65                  70                  75                  80
 Leu Lys Thr Lys Gln Leu Ser Leu Thr Ile Asn Lys Pro Ser Phe Arg
                  85                  90                  95    
 Leu Thr Arg Cys Gly Ile Arg Met Thr Ser Ser Asn Met Pro Leu Pro
             100                 105                 110        
 Ala Ser Ser Ser Thr Gln Arg Ile Val Gln Gly Arg Glu Thr Ala Met
         115                 120                 125            
 Glu Gly Glu Trp Pro Trp Gln Ala Ser Leu Gln Leu Ile Gly Ser Gly
     130                 135                 140                
 His Gln Cys Gly Ala Ser Leu Ile Ser Asn Thr Trp Leu Leu Thr Ala
 145                 150                 155                 160
 Ala His Cys Phe Trp Lys Asn Lys Asp Pro Thr Gln Trp Ile Ala Thr
                 165                 170                 175    
 Phe Gly Ala Thr Ile Thr Pro Pro Ala Val Lys Arg Asn Val Arg Lys
             180                 185                 190        
 Ile Ile Leu His Glu Asn Tyr His Arg Glu Thr Asn Glu Asn Asp Ile
         195                 200                 205            
 Ala Leu Val Gln Leu Ser Thr Gly Val Glu Phe Ser Asn Ile Val Gln
     210                 215                 220                
 Arg Val Cys Leu Pro Asp Ser Ser Ile Lys Leu Pro Pro Lys Thr Ser
 225                 230                 235                 240
 Val Phe Val Thr Gly Phe Gly Ser Ile Val Asp Asp Gly Pro Ile Gln
                 245                 250                 255    
 Asn Thr Leu Arg Gln Ala Arg Val Glu Thr Ile Ser Thr Asp Val Cys
             260                 265                 270        
 Asn Arg Lys Asp Val Tyr Asp Gly Leu Ile Thr Pro Gly Met Leu Cys
         275                 280                 285            
 Ala Gly Phe Met Glu Gly Lys Ile Asp Ala Cys Lys Gly Asp Ser Gly
     290                 295                 300                
 Gly Pro Leu Val Tyr Asp Asn His Asp Ile Trp Tyr Ile Val Gly Ile
 305                 310                 315                 320
 Val Ser Trp Gly Gln Ser Cys Ala Leu Pro Lys Lys Pro Gly Val Tyr
                 325                 330                 335    
 Thr Arg Val Thr Lys Tyr Arg Asp Trp Ile Ala Ser Lys Thr Gly Ser
             340                 345                 350        
 Ser Ser Leu Arg Thr Asp Thr Asn Glu Leu Pro Gly Gln Ile Ser Ser
         355                 360                 365            
 Ala Gln Val Ser Leu Pro Glu Glu Lys Gln Ile Lys Gly His Arg Met
     370                 375                 380                
 Phe Tyr Glu Asn Leu Trp Cys Val Lys Ser Leu Pro Leu Lys Glu Met
 385                 390                 395                 400
 Asn Ile Arg Ala
                



      <210> 1275
      <211> 267
      <212> PRT
      <213> Homo sapiens


      <400> 1275
 Met Ala Pro Leu Arg Phe Ser Ala Asn Leu Ser Trp Leu Phe Pro Glu
   1               5                  10                  15    
 Leu Pro Gly Leu Pro Ala Arg Val Arg Ala Ala Gly Ser Ser Gly Phe
              20                  25                  30        
 Glu Ala Val Glu Val Ala Trp Pro Tyr Ala Glu Thr Pro Glu Ala Leu
          35                  40                  45            
 Ala Arg Ala Ala Arg Glu Ala Gly Leu Arg Leu Val Leu Ile Asn Thr
      50                  55                  60                
 Pro Pro Gly Asp Gln Glu Lys Gly Glu Met Gly Leu Gly Ala Val Pro
  65                  70                  75                  80
 Gly Arg Gln Ala Ala Phe Arg Glu Gly Leu Glu Gln Ala Val Arg Tyr
                  85                  90                  95    
 Ala Lys Ala Leu Gly Cys Pro Arg Ile His Leu Met Ala Gly Arg Val
             100                 105                 110        
 Pro Gln Gly Ala Asp Arg Ile Ala Val Lys Ala Glu Met Glu Ala Val
         115                 120                 125            
 Phe Leu Glu Asn Leu Arg His Ala Ala Gly Val Leu Ala Gln Glu Asp
     130                 135                 140                
 Leu Val Gly Leu Leu Glu Pro Ile Asn Thr Arg Ile Thr Asp Pro Gln
 145                 150                 155                 160
 Tyr Phe Leu Asp Thr Pro Gln Gln Val Ala Ala Ile Leu Gln Lys Asp
                 165                 170                 175    
 Ile Phe His Trp Gln Ile Met Asp Gly Asn Leu Thr Gly Asn Ile Arg
             180                 185                 190        
 Glu Phe Leu Pro Ile Val Gly His Val Gln Val Ala Gln Val Pro Gly
         195                 200                 205            
 Arg Gly Glu Pro Ser Ser Pro Gly Glu Leu Asn Phe Pro Tyr Leu Phe
     210                 215                 220                
 Gln Leu Leu Glu Asp Glu Gly Tyr Lys Gly Phe Val Gly Cys Glu Tyr
 225                 230                 235                 240
 Gln Pro Arg Gly Asp Thr Val Glu Gly Leu Ser Trp Leu Arg Ser Tyr
                 245                 250                 255    
 Trp Asp Arg Arg Gly His Pro Glu Ala Gly Gln
             260                 265        



      <210> 1276
      <211> 48
      <212> PRT
      <213> Homo sapiens


      <400> 1276
 Met Asp Phe Phe Phe Leu Glu Arg Ser Tyr Trp Gly Lys Met Ile Leu
   1               5                  10                  15    
 Leu Leu Val Thr Tyr Ser Pro Ile Ala Tyr Ser His Pro Pro Arg Phe
              20                  25                  30        
 Glu Ile Ala Pro Leu Gly Arg Leu Arg Arg Ala Arg Ser Arg Ala Glu
          35                  40                  45            





      <210> 1277
      <211> 90
      <212> PRT
      <213> Homo sapiens


      <400> 1277
 Met Val Thr Ile Leu Asp Arg Val Leu Val Leu Glu Cys Gly Phe Ser
   1               5                  10                  15    
 Val Ala Pro Asn Phe Ser Val His Leu Ser Cys Asn Gly Leu Gly Ser
              20                  25                  30        
 Thr Leu Thr Glu Pro Leu His Ile Phe Ser Arg His Pro Val His Val
          35                  40                  45            
 Lys Glu Glu Pro Leu Asp Pro Glu Glu Ala Glu Gly Pro Leu Ser Leu
      50                  55                  60                
 Val Thr Thr Ala Asn His Ser Pro Asp Phe Asp His Asp Arg Asp Tyr
  65                  70                  75                  80
 Glu Asp Glu Pro Val Asn Glu Asp Met Glu
                  85                  90



      <210> 1278
      <211> 63
      <212> PRT
      <213> Homo sapiens


      <400> 1278
 Met Thr Phe Ile Ser Phe Ser Ser Leu Ile Ala Leu Ser Lys Thr Ser
   1               5                  10                  15    
 Ser Thr Met Ala Trp Pro Lys Ile Pro Phe Leu Gly Ile Arg Glu Ala
              20                  25                  30        
 Lys Asn Pro Arg Ser Glu Asn Thr Arg Leu Ala Thr Ile Leu Glu Ala
          35                  40                  45            
 Ala His His His Leu Gly Ser Ser Pro Pro Pro Ser Trp Glu Leu
      50                  55                  60            



      <210> 1279
      <211> 227
      <212> PRT
      <213> Homo sapiens


      <400> 1279
 Met Thr Leu Gln Asp Phe Lys Thr His Phe Val Leu Leu Val Ile Cys
   1               5                  10                  15    
 Lys Leu Thr Pro Gly Leu Leu Ser Gln Glu Ala Ala Gln Lys Trp Thr
              20                  25                  30        
 Tyr Thr Met Arg Glu Gly Arg Trp Glu Lys Arg Ser Thr Ala Gly Gly
          35                  40                  45            
 Gln Arg Gln Leu Leu Gln Asp Thr Phe Trp Lys Asn Pro Gln Phe Leu
      50                  55                  60                
 Leu Ser Val Trp Arg Pro Glu Glu Gly Arg Arg Ser Leu Arg Pro Cys
  65                  70                  75                  80
 Ser Val Leu Val Ser Leu Leu Gln Lys Pro Arg His Arg Cys Arg Lys
                  85                  90                  95    
 Arg Lys Pro Leu Leu Ala Ile Gly Phe Tyr Leu Tyr Arg Tyr His Asp
             100                 105                 110        
 Asp Gln Arg Arg Leu Pro Pro Glu Phe Phe Gln Arg Asn Thr Pro Leu
         115                 120                 125            
 Ser Gln Pro Asp Arg Phe Leu Lys Glu Lys Glu Val Ser Gln Glu Leu
     130                 135                 140                
 Cys Leu Glu Pro Gly Thr Tyr Leu Ile Val Pro Cys Ile Leu Glu Ala
 145                 150                 155                 160
 His Gln Lys Ser Glu Phe Val Leu Arg Val Phe Ser Arg Lys His Ile
                 165                 170                 175    
 Phe Tyr Glu Ile Gly Ser Asn Ser Gly Val Val Phe Ser Lys Glu Ile
             180                 185                 190        
 Glu Asp Gln Asn Glu Arg Gln Asp Glu Phe Phe Thr Lys Phe Phe Glu
         195                 200                 205            
 Lys Ile Cys Phe Leu Thr Pro Arg Phe Cys Ser His Asn Phe Ser Leu
     210                 215                 220                
 Gly Leu Pro
 225        



      <210> 1280
      <211> 170
      <212> PRT
      <213> Homo sapiens


      <400> 1280
 Met Val Cys Phe Asn Met Gly Arg Ile Thr Leu Ala Lys Lys Leu Ala
   1               5                  10                  15    
 Arg Lys Ala Leu Arg Leu Leu Lys Arg Asn Phe Pro Trp Thr Trp Phe
              20                  25                  30        
 Gly Val Leu Phe Gln Thr Phe Leu Glu Lys Tyr Trp His Ser Cys Thr
          35                  40                  45            
 Leu Ser Gln Pro Pro Asn Asp Pro Ser Glu Asn Lys Lys Asn Leu Ala
      50                  55                  60                
 Val Leu Gln Gln Gln Val His Cys Leu Ser Leu Leu Trp Gln Leu Tyr
  65                  70                  75                  80
 Asn Leu Glu Ala Thr Ala Ser Ser Tyr Arg Phe Ala Cys Leu Ala Thr
                  85                  90                  95    
 Leu Met Gln Lys Asn Ser Ala Asp Glu Phe Ala Asn Glu Ala Gln Ser
             100                 105                 110        
 Val Gly Ile Lys Asp Lys Trp Leu His Cys Glu Gln Met Ala Ile Gln
         115                 120                 125            
 Lys Ser Ser Leu Cys Trp Phe Ser Arg Glu Gly Leu Leu Ala Thr Ala
     130                 135                 140                
 Gln Leu Met Gln Ala Leu Ala Tyr Thr Lys Leu Cys Leu Gly His Leu
 145                 150                 155                 160
 Asp Phe Ser Ile Lys Leu Gly Asn Gly Thr
                 165                 170



      <210> 1281
      <211> 371
      <212> PRT
      <213> Homo sapiens


      <400> 1281
 Met Asp Ala Ala Ala His Leu Gly Ile Thr Leu Ile Thr Thr Ile Leu
   1               5                  10                  15    
 Pro Tyr Val Met Met Asn His Glu Met Phe Tyr Ile Arg Arg Lys Val
              20                  25                  30        
 Gln Thr Gln Glu Lys Ala Val Gly Lys Thr Gly Thr Arg Met Lys Glu
          35                  40                  45            
 Arg Thr Leu Val Lys Glu Phe Met Pro Gln Leu Ser Val Thr Glu Asn
      50                  55                  60                
 Val Ile Gln Gly Ile Pro Ile Val Lys Met Ala Gln Glu Ala Lys Gly
  65                  70                  75                  80
 Ala Asn Lys Asn Arg Asn Thr Glu Ala Ser Thr Thr Gly Ser Lys Arg
                  85                  90                  95    
 Arg Gln Leu Leu Lys Lys Leu Glu Met Val Pro Gly Ile Lys Ser Cys
             100                 105                 110        
 Arg Val Thr Ala Phe Ile Pro Thr Gln Asp Val Asn Asp His Trp Ala
         115                 120                 125            
 His Pro Ser Ser Asp Ala Asp Glu Met Arg Ser Ala Tyr Pro Glu His
     130                 135                 140                
 Ala Gly Gly His Ser Gly Met Pro Ser His Leu Met Ser Val Gly Pro
 145                 150                 155                 160
 Asn Gln Leu Thr His Ser Phe Ile Phe Asn Ile Leu Asp Ala Glu Ser
                 165                 170                 175    
 Val Ile Cys His Gln Thr Trp Asn Thr Lys Ser Met Pro Pro Met Glu
             180                 185                 190        
 Asn Thr Arg Gln Ser Thr Ala Asp Thr Pro Thr Gln Ile Asn Val Pro
         195                 200                 205            
 Ile Ser Thr Asp Thr Ser Asp Arg Tyr Lys Arg Cys Val Arg Asp Asp
     210                 215                 220                
 Trp Gly Asn Tyr Glu Thr Gln Lys Asp Asn Leu Asp Thr Glu His Lys
 225                 230                 235                 240
 Lys Cys Thr Leu Leu Thr Thr Glu Ser Glu Lys Asn Gly Lys Gly Lys
                 245                 250                 255    
 Arg Cys Ser Asp Asp Arg Thr Leu Arg Glu Asp Trp Leu Pro Leu Arg
             260                 265                 270        
 Gly Arg Arg Leu Thr Gly Ser Lys His Arg Val Ser His Pro Val Phe
         275                 280                 285            
 Gln Asn Pro Leu Pro Glu Arg Leu Pro Phe Ile Leu Thr Val Thr Ser
     290                 295                 300                
 Leu Leu Val Ala Ser Ser Pro Ser Ala Pro Glu Ala Arg Asp Ala Cys
 305                 310                 315                 320
 Ser Asn Ser Asp Pro Gly Ile Leu Phe Ala Gln Leu Gln Phe Asn Pro
                 325                 330                 335    
 Ser Leu Leu Gly Ile Phe Pro Thr Gly Lys Cys Asp Leu Ile Val Leu
             340                 345                 350        
 Tyr Lys Thr Leu Gln Trp His Leu Leu Pro Ser Glu Tyr Ile Ser Cys
         355                 360                 365            
 Leu Pro Leu
     370    



      <210> 1282
      <211> 59
      <212> PRT
      <213> Homo sapiens


      <400> 1282
 Met Leu Pro His Asp Leu Cys Val Leu Ile Gln Pro Ser Ile Glu Ser
   1               5                  10                  15    
 Ala Gln Ala Leu Leu Ser Phe Arg Val Ser Ala Ala Pro Ser Gly Arg
              20                  25                  30        
 Arg Cys Leu Phe Gly Ser Ala Leu Ser Leu Pro Val Cys Ala Ala Leu
          35                  40                  45            
 Gly Arg Leu Pro Tyr His Met Gly Leu Thr Lys
      50                  55                



      <210> 1283
      <211> 107
      <212> PRT
      <213> Homo sapiens


      <400> 1283
 Met Lys Pro Arg Thr Leu Gly Lys Leu Leu Glu Gly Arg Gly Met Pro
   1               5                  10                  15    
 Ala Ile Phe Ile Ile Ala Leu Pro Ser Pro Asn Thr Ile Arg Glu Pro
              20                  25                  30        
 Ala Leu Ile Ile Ser Leu Gln Leu Tyr Pro Ala Ala Pro Glu Arg Gln
          35                  40                  45            
 Arg Pro Ala Arg Arg Gly His Asp Asp Gly Gly Gly Phe Phe Lys Thr
      50                  55                  60                
 Lys Arg Gly Ile Cys Arg Glu Lys Lys Glu Arg Ser Asp Ser Tyr Arg
  65                  70                  75                  80
 Leu Leu Leu Cys Leu His Arg Lys Gly Arg His Lys Arg Leu His Leu
                  85                  90                  95    
 Glu Lys Asp Leu Tyr Phe Lys Gln Leu Leu Cys
             100                 105        



      <210> 1284
      <211> 194
      <212> PRT
      <213> Homo sapiens


      <400> 1284
 Met Ala Ala Ser Ala Phe Ala Gly Ala Val Arg Ala Ala Ser Gly Gln
   1               5                  10                  15    
 Trp Arg Ala Thr Tyr Ser Met His Ala Phe Thr Glu Gly Glu Thr Gly
              20                  25                  30        
 Ile Leu Arg Ser Leu Asn Ile Leu Ala Ser Ser Thr Tyr Arg Asn Cys
          35                  40                  45            
 Val Lys Asn Ala Ser Leu Ile Ser Ala Leu Ser Thr Gly Arg Phe Ser
      50                  55                  60                
 His Ile Gln Thr Pro Val Val Ser Ser Thr Pro Arg Leu Thr Thr Ser
  65                  70                  75                  80
 Glu Arg Asn Leu Thr Cys Gly His Thr Ser Val Ile Leu Asn Arg Met
                  85                  90                  95    
 Ala Pro Val Leu Pro Ser Val Leu Lys Leu Pro Val Arg Ser Leu Thr
             100                 105                 110        
 Tyr Phe Ser Ala Arg Lys Gly Lys Arg Lys Thr Val Lys Ala Val Ile
         115                 120                 125            
 Asp Arg Phe Leu Arg Leu His Cys Gly Leu Trp Val Arg Arg Lys Ala
     130                 135                 140                
 Gly Tyr Lys Lys Lys Leu Trp Lys Lys Thr Pro Ala Arg Lys Lys Arg
 145                 150                 155                 160
 Leu Arg Glu Phe Val Phe Cys Asn Lys Thr Gln Ser Lys Leu Leu Asp
                 165                 170                 175    
 Lys Met Thr Thr Ser Phe Trp Lys Arg Arg Asn Trp His Ser Pro Ile
             180                 185                 190        
 Cys Arg
        



      <210> 1285
      <211> 205
      <212> PRT
      <213> Homo sapiens


      <400> 1285
 Met Ala Ala Ser Ala Phe Ala Gly Ala Val Arg Ala Ala Ser Gly Gln
   1               5                  10                  15    
 Trp Arg Ala Thr Tyr Ser Met His Ala Phe Thr Glu Gly Glu Thr Gly
              20                  25                  30        
 Ile Leu Arg Pro Leu Asn Ile Leu Ala Ser Ser Thr Tyr Arg Asn Cys
          35                  40                  45            
 Val Lys Asn Ala Ser Leu Ile Ser Ala Leu Ser Thr Gly Arg Phe Ser
      50                  55                  60                
 His Ile Gln Thr Pro Val Val Ser Ser Thr Pro Arg Leu Thr Thr Ser
  65                  70                  75                  80
 Glu Arg Asn Leu Thr Cys Gly His Thr Ser Val Ile Leu Asn Arg Met
                  85                  90                  95    
 Ala Pro Val Leu Pro Ser Val Leu Lys Leu Pro Val Arg Ser Leu Thr
             100                 105                 110        
 Tyr Phe Ser Ala Arg Lys Gly Lys Arg Lys Thr Val Lys Ala Val Ile
         115                 120                 125            
 Asp Arg Phe Leu Arg Leu His Cys Gly Leu Trp Val Arg Arg Lys Ala
     130                 135                 140                
 Gly Tyr Lys Lys Lys Leu Trp Lys Lys Thr Pro Ala Arg Lys Lys Arg
 145                 150                 155                 160
 Leu Arg Glu Phe Val Phe Cys Asn Lys Thr Gln Ser Lys Leu Leu Asp
                 165                 170                 175    
 Lys Met Thr Thr Ser Phe Trp Lys Arg Arg Asn Trp Tyr Val Asp Asp
             180                 185                 190        
 Pro Tyr Gln Lys Tyr His Asp Arg Thr Asn Leu Lys Val
         195                 200                 205



      <210> 1286
      <211> 322
      <212> PRT
      <213> Homo sapiens


      <400> 1286
 Met Cys Leu Leu Arg Ala Gly Val Ala Gly Pro Gly Ser Ala Arg Ala
   1               5                  10                  15    
 Val Pro Thr Ala Ser Gln Cys Pro Phe Val Asp Leu Ala Lys Leu Ser
              20                  25                  30        
 Trp Gly Ala Val Asn Thr Gly Leu Ser Pro Ser Pro Leu Leu Val Phe
          35                  40                  45            
 His Asp Thr Tyr Pro Gly Ser Pro Asp Pro Lys Glu Ser Gly Cys Trp
      50                  55                  60                
 Ala Asn Pro Gly Pro Phe Pro Gly Glu Pro Gly Gln Gly Lys Val Ala
  65                  70                  75                  80
 Phe Pro Gly Glu Pro Gly Thr Gly Thr Arg Pro Tyr Gln Ser Asn Arg
                  85                  90                  95    
 Met Ala Lys Cys Ala Ala Ala Ser Leu Gly Trp Leu Ile Trp Gln Ile
             100                 105                 110        
 Leu Leu Arg Arg Arg Pro Val Pro Val Lys Pro Cys Ser Phe Leu Arg
         115                 120                 125            
 Gly Thr Val Pro Glu Thr His Gln Asp Ser Ala Trp Ile Pro Ala Ser
     130                 135                 140                
 Pro Ser His Pro Ser Ala Ile Leu Ser Pro Lys Thr Trp Thr Glu Ser
 145                 150                 155                 160
 His Leu Gly Leu Leu Trp Pro Ala Cys Gly Pro Ile Pro Val Pro Trp
                 165                 170                 175    
 Ser Ala Thr Leu Leu Ser Arg Thr Pro Ala Val Arg Leu Lys Gly Arg
             180                 185                 190        
 His Arg Val Arg His Ser Gly Leu Cys Met Ala Lys Leu Ser Gln Val
         195                 200                 205            
 Leu Ser Glu Ala Val Pro Gly Ala Cys Cys Ser Pro Ser Leu Tyr His
     210                 215                 220                
 Val Ala Asp Pro Ala Cys Gly Val Lys Leu Asn Leu Glu Asp Thr Glu
 225                 230                 235                 240
 Gln Asp Thr Asp Thr His Arg Gly Ala Lys Pro Asn Pro Glu Gln Arg
                 245                 250                 255    
 Glu Glu Asn Pro Lys Glu Thr Glu Trp Leu Gly Phe Lys Asp Thr Met
             260                 265                 270        
 Lys Met Glu Glu Ser Gln Arg Phe Ala Leu Gly Tyr Gly Glu Lys Ser
         275                 280                 285            
 Lys Ala Asn Lys Asn Ala Phe Gly Arg Leu Ser Ser Thr Asp Leu Arg
     290                 295                 300                
 Gly Leu Asp Ser Ser Leu Glu Lys Trp Met Pro Lys Glu Glu Ile Lys
 305                 310                 315                 320
 Lys Val
        



      <210> 1287
      <211> 425
      <212> PRT
      <213> Homo sapiens


      <400> 1287
 Met Ala Ala Val Ser Pro Thr Thr Arg Cys Gln Glu Ser Val Thr Phe
   1               5                  10                  15    
 Glu Asp Val Ala Val Val Phe Thr Asp Glu Glu Trp Ser Arg Leu Val
              20                  25                  30        
 Pro Ile Gln Arg Asp Leu Tyr Lys Glu Val Met Leu Glu Asn Tyr Asn
          35                  40                  45            
 Ser Ile Val Ser Leu Gly Leu Pro Val Pro Gln Pro Asp Val Ile Phe
      50                  55                  60                
 Gln Leu Lys Arg Gly Asp Lys Pro Trp Met Val Asp Leu His Gly Ser
  65                  70                  75                  80
 Glu Glu Arg Glu Trp Pro Glu Ser Val Ser Leu Asp Trp Glu Thr Lys
                  85                  90                  95    
 Pro Glu Ile His Asp Ala Ser Asp Lys Lys Ser Glu Gly Ser Leu Arg
             100                 105                 110        
 Glu Cys Leu Gly Arg Gln Ser Pro Leu Cys Pro Lys Phe Glu Val His
         115                 120                 125            
 Thr Pro Asn Gly Arg Met Gly Thr Glu Lys Gln Ser Pro Ser Gly Glu
     130                 135                 140                
 Thr Arg Lys Lys Ser Leu Ser Arg Asp Lys Gly Leu Arg Arg Arg Ser
 145                 150                 155                 160
 Ala Leu Ser Arg Glu Ile Leu Thr Lys Glu Arg His Gln Glu Cys Ser
                 165                 170                 175    
 Asp Cys Gly Lys Thr Phe Phe Asp His Ser Ser Leu Thr Arg His Gln
             180                 185                 190        
 Arg Thr His Thr Gly Glu Lys Pro Tyr Asp Cys Arg Glu Cys Gly Lys
         195                 200                 205            
 Ala Phe Ser His Arg Ser Ser Leu Ser Arg His Leu Met Ser His Thr
     210                 215                 220                
 Gly Glu Ser Pro Tyr Glu Cys Ser Val Cys Ser Lys Ala Phe Phe Asp
 225                 230                 235                 240
 Arg Ser Ser Leu Thr Val His Gln Arg Ile His Thr Gly Glu Lys Pro
                 245                 250                 255    
 Phe Gln Cys Asn Glu Cys Gly Lys Ala Phe Phe Asp Arg Ser Ser Leu
             260                 265                 270        
 Thr Arg His Gln Arg Ile His Thr Gly Glu Ser Pro Tyr Glu Cys His
         275                 280                 285            
 Gln Cys Gly Lys Ala Phe Ser Gln Lys Ser Ile Leu Thr Arg His Gln
     290                 295                 300                
 Leu Ile His Thr Gly Arg Lys Pro Tyr Glu Cys Asn Glu Cys Gly Lys
 305                 310                 315                 320
 Ala Phe Tyr Gly Val Ser Ser Leu Asn Arg His Gln Lys Ala His Ala
                 325                 330                 335    
 Gly Asp Pro Arg Tyr Gln Cys Asn Glu Cys Gly Lys Ala Phe Phe Asp
             340                 345                 350        
 Arg Ser Ser Leu Thr Gln His Gln Lys Ile His Thr Gly Asp Lys Pro
         355                 360                 365            
 Tyr Glu Cys Ser Glu Cys Gly Lys Ala Phe Ser Gln Arg Cys Arg Leu
     370                 375                 380                
 Thr Arg His Gln Arg Val His Thr Gly Glu Lys Pro Phe Glu Cys Thr
 385                 390                 395                 400
 Val Cys Gly Lys Val Phe Ser Ser Lys Ser Ser Val Ile Gln His Gln
                 405                 410                 415    
 Arg Arg Tyr Ala Lys Gln Gly Ile Asp
             420                 425



      <210> 1288
      <211> 105
      <212> PRT
      <213> Homo sapiens


      <400> 1288
 Met Thr Leu Gly Ser Ile Asn Cys Lys Phe Val Leu Pro Asn His Phe
   1               5                  10                  15    
 Trp Val Phe Lys Glu Phe Leu Asp Thr Leu Ile Ala Cys Leu Gln Phe
              20                  25                  30        
 Asp Pro Leu Phe Phe Leu Phe Val Arg Cys Thr Arg Leu Pro Ser Cys
          35                  40                  45            
 Phe Ser Leu Leu Ser Cys His Gln Pro Phe Leu Leu Gly Gly His Val
      50                  55                  60                
 Leu Gly Lys Arg Pro His Asp Leu Ser Gly Ser Thr Gln Cys Leu Lys
  65                  70                  75                  80
 Ala Pro Cys Phe Leu Cys Leu His Pro Thr Asp Tyr Phe Pro His Pro
                  85                  90                  95    
 Ile Tyr Cys Ser Lys Ser Leu Leu Ser
             100                 105



      <210> 1289
      <211> 88
      <212> PRT
      <213> Homo sapiens


      <400> 1289
 Met Leu Glu Cys Ala Phe Thr Phe Cys Asp Val Met Cys Gln Phe Ile
   1               5                  10                  15    
 Asn Trp Thr Pro Ser Pro Val Arg Val Leu Ala Lys His Arg Gly Tyr
              20                  25                  30        
 Pro Glu Ile Gly Trp Ile Gly Glu Phe Asn Asn Asp Gly Ile Ile His
          35                  40                  45            
 Lys Gly Cys Gly Gln Gly Lys Ala Ala Met Ala Ala Thr Trp Leu Ala
      50                  55                  60                
 Ile Leu Leu Asp Leu Lys Arg Gln Arg Asn Glu Gly Val Thr Arg Pro
  65                  70                  75                  80
 Gly Asp Val Val Glu Ala Cys Leu
                  85            



      <210> 1290
      <211> 92
      <212> PRT
      <213> Homo sapiens


      <400> 1290
 Met Asp Thr Leu Val Ser Ser Asp Cys Lys Tyr Ile Ala Cys Phe Ile
   1               5                  10                  15    
 Leu Met Val His Tyr Phe Ile Gln Gln Ala Phe His Leu Arg Met Phe
              20                  25                  30        
 Asn Val Asp Leu Ile Leu Arg Ala Ser Arg Ser Lys Tyr Phe Ser Ala
          35                  40                  45            
 Glu Leu Leu Gly Ser His Tyr Ser Val Val Gln Cys Cys Lys Lys His
      50                  55                  60                
 His Val Glu Glu Trp Glu Leu Cys Leu Leu Tyr Glu Val Met Tyr Asn
  65                  70                  75                  80
 Thr Met Lys Ser Val Leu Gln Leu Leu Cys Cys Ile
                  85                  90        



      <210> 1291
      <211> 472
      <212> PRT
      <213> Homo sapiens


      <400> 1291
 Met Ala Phe Asn Phe Gly Ala Pro Ser Gly Thr Ser Gly Thr Ala Ala
   1               5                  10                  15    
 Ala Thr Ala Ala Pro Ala Gly Gly Phe Gly Gly Phe Gly Thr Thr Ser
              20                  25                  30        
 Thr Thr Ala Gly Ser Ala Phe Ser Phe Ser Ala Pro Thr Asn Thr Gly
          35                  40                  45            
 Thr Thr Gly Leu Phe Gly Gly Thr Gln Asn Lys Gly Phe Gly Phe Gly
      50                  55                  60                
 Thr Gly Phe Gly Thr Thr Thr Gly Thr Ser Thr Gly Leu Gly Thr Gly
  65                  70                  75                  80
 Leu Gly Thr Gly Leu Gly Phe Gly Gly Phe Asn Thr Gln Gln Gln Gln
                  85                  90                  95    
 Gln Gln Thr Thr Leu Gly Gly Leu Phe Ser Gln Pro Thr Gln Ala Pro
             100                 105                 110        
 Thr Gln Ser Asn Gln Leu Ile Asn Thr Ala Ser Ala Leu Ser Ala Pro
         115                 120                 125            
 Thr Leu Leu Gly Asp Glu Arg Asp Ala Ile Leu Ala Lys Trp Asn Gln
     130                 135                 140                
 Leu Gln Ala Phe Trp Gly Thr Gly Lys Gly Tyr Phe Asn Asn Asn Ile
 145                 150                 155                 160
 Pro Pro Val Glu Phe Thr Gln Glu Asn Pro Phe Cys Arg Phe Lys Ala
                 165                 170                 175    
 Val Gly Tyr Ser Cys Met Pro Ser Asn Lys Asp Glu Asp Gly Leu Val
             180                 185                 190        
 Val Leu Val Phe Asn Lys Lys Glu Thr Glu Ile Arg Ser Gln Gln Gln
         195                 200                 205            
 Gln Leu Val Glu Ser Leu His Lys Val Leu Gly Gly Asn Gln Thr Leu
     210                 215                 220                
 Thr Val Asn Val Glu Gly Thr Lys Thr Leu Pro Asp Asp Gln Thr Glu
 225                 230                 235                 240
 Val Val Ile Tyr Val Val Glu Arg Ser Pro Asn Gly Thr Ser Arg Arg
                 245                 250                 255    
 Val Pro Ala Thr Thr Leu Tyr Ala His Phe Glu Gln Ala Asn Ile Lys
             260                 265                 270        
 Thr Gln Leu Gln Gln Leu Gly Val Thr Leu Ser Met Thr Arg Thr Glu
         275                 280                 285            
 Leu Ser Pro Ala Gln Ile Lys Gln Leu Leu Gln Asn Pro Pro Ala Gly
     290                 295                 300                
 Val Asp Pro Ile Ile Trp Glu Gln Ala Lys Val Asp Asn Ser Asp Ser
 305                 310                 315                 320
 Glu Lys Leu Ile Pro Val Pro Met Val Gly Phe Lys Glu Leu Leu Arg
                 325                 330                 335    
 Arg Leu Lys Val Gln Asp Gln Met Thr Lys Gln His Gln Thr Arg Leu
             340                 345                 350        
 Asp Val Leu Ile Lys Gln Glu Ile Gln Arg Lys Ser Gly Tyr Ala Ile
         355                 360                 365            
 Gln Ala Asp Glu Glu Gln Leu Arg Val Gln Leu Asp Thr Ile Gln Gly
     370                 375                 380                
 Glu Leu Asn Ala Pro Thr Gln Phe Lys Gly Arg Leu Asn Glu Leu Met
 385                 390                 395                 400
 Ser Gln Ile Arg Met Gln Asn His Phe Gly Ala Val Arg Ser Glu Glu
                 405                 410                 415    
 Arg Tyr Tyr Ile Asp Ala Asp Leu Leu Arg Glu Ile Lys Gln His Leu
             420                 425                 430        
 Lys Gln Gln Gln Glu Gly Leu Ser His Leu Ile Ser Ile Ile Lys Asp
         435                 440                 445            
 Asp Leu Glu Asp Ile Lys Leu Val Glu His Gly Leu Asn Glu Thr Ile
     450                 455                 460                
 His Ile Arg Gly Gly Val Phe Ser
 465                 470        



      <210> 1292
      <211> 82
      <212> PRT
      <213> Homo sapiens


      <400> 1292
 Met Ala Leu Gly Val Pro Ile Ser Val Tyr Leu Leu Phe Asn Ala Asp
   1               5                  10                  15    
 Asn Ile Glu Gly Pro Ile Ala Leu Lys Phe Ser His Leu Cys Leu Glu
              20                  25                  30        
 Asp His Asn Ser Tyr Cys Ile Asn Gly Ala Cys Ala Phe His His Glu
          35                  40                  45            
 Leu Glu Lys Ala Ile Cys Arg Cys Phe Thr Gly Tyr Thr Gly Glu Arg
      50                  55                  60                
 Cys Leu Lys Leu Lys Ser Pro Tyr Asn Val Cys Ser Gly Glu Arg Arg
  65                  70                  75                  80
 Pro Leu
        



      <210> 1293
      <211> 201
      <212> PRT
      <213> Homo sapiens


      <400> 1293
 Met Ala Gln His Phe Ser Leu Ala Ala Cys Asp Val Val Gly Phe Asp
   1               5                  10                  15    
 Leu Asp His Thr Leu Cys Arg Tyr Asn Leu Pro Glu Ser Ala Pro Leu
              20                  25                  30        
 Ile Tyr Asn Ser Phe Ala Gln Phe Leu Val Lys Glu Lys Gly Tyr Asp
          35                  40                  45            
 Lys Glu Leu Leu Asn Val Thr Pro Glu Asp Trp Asp Phe Cys Cys Lys
      50                  55                  60                
 Gly Leu Ala Leu Asp Leu Glu Asp Gly Asn Phe Leu Lys Leu Ala Asn
  65                  70                  75                  80
 Asn Gly Thr Val Leu Arg Ala Ser His Gly Thr Lys Met Met Thr Pro
                  85                  90                  95    
 Glu Val Leu Ala Glu Ala Tyr Gly Lys Lys Glu Trp Lys His Phe Leu
             100                 105                 110        
 Ser Asp Thr Gly Met Ala Cys Arg Ser Gly Lys Tyr Tyr Phe Tyr Asp
         115                 120                 125            
 Asn Tyr Phe Asp Leu Pro Gly Ala Leu Leu Cys Ala Arg Val Val Asp
     130                 135                 140                
 Tyr Leu Thr Lys Leu Asn Asn Gly Gln Lys Thr Phe Asp Phe Trp Lys
 145                 150                 155                 160
 Asp Ile Val Ala Ala Ile Gln His Asn Tyr Lys Met Ser Ala Phe Lys
                 165                 170                 175    
 Glu Asn Cys Gly Ile Tyr Phe Pro Glu Ile Asn Thr Glu Ile Gln Ala
             180                 185                 190        
 Asp Ile Tyr Ile Val Val Leu Asn Leu
         195                 200    



      <210> 1294
      <211> 225
      <212> PRT
      <213> Homo sapiens


      <400> 1294
 Met Val Gly Ala Ala His Arg Ala Gln Ala Val Phe Thr Val Val Ser
   1               5                  10                  15    
 Ser Glu Leu Lys Gly Met Cys Phe His Leu Pro Met Arg Thr Ala Pro
              20                  25                  30        
 Ser Val Ser Val Trp Leu Glu Thr Cys Pro Ala Ser Leu Leu Ser Val
          35                  40                  45            
 Leu Leu Ala Pro Val Arg Pro Pro Pro Gln Thr Asp Cys Cys Thr Cys
      50                  55                  60                
 Val Pro Val Arg Cys Tyr Phe His Gly Arg Trp Tyr Ala Asp Gly Ala
  65                  70                  75                  80
 Val Phe Ser Gly Gly Gly Asp Glu Cys Thr Thr Cys Val Cys Gln Asn
                  85                  90                  95    
 Gly Glu Val Glu Cys Ser Phe Met Pro Cys Pro Glu Leu Ala Cys Pro
             100                 105                 110        
 Arg Glu Glu Trp Arg Leu Gly Pro Gly Gln Cys Cys Phe Thr Cys Gln
         115                 120                 125            
 Glu Pro Thr Pro Ser Thr Gly Cys Ser Leu Asp Asp Asn Gly Val Glu
     130                 135                 140                
 Phe Pro Ile Gly Gln Ile Trp Ser Pro Gly Asp Pro Cys Glu Leu Cys
 145                 150                 155                 160
 Ile Cys Gln Gly Gly Glu Ala Gly Ala Gly Val Ser Gly Gly Val Leu
                 165                 170                 175    
 Val Lys Phe Leu Leu Pro Pro Gly Arg Trp Leu Gly Glu Leu Gln Glu
             180                 185                 190        
 Asp Arg Leu Cys Gly Leu Leu Pro Ser Pro Asp Pro Asp Pro Trp Thr
         195                 200                 205            
 Val Leu Pro Arg Leu Phe Ser Arg Leu His Leu His Arg Gln Asn Leu
     210                 215                 220                
 Leu
 225



      <210> 1295
      <211> 517
      <212> PRT
      <213> Homo sapiens


      <400> 1295
 Met Thr Lys Phe Gln Glu Ala Val Thr Phe Lys Asp Val Ala Val Val
   1               5                  10                  15    
 Phe Thr Glu Glu Glu Leu Gly Leu Leu Asp Pro Ala Gln Arg Lys Leu
              20                  25                  30        
 Tyr Arg Asp Val Met Leu Glu Asn Phe Arg Asn Leu Leu Ser Val Gly
          35                  40                  45            
 His Gln Ser Phe Lys Pro Asp Met Ile Ser Gln Leu Glu Arg Glu Glu
      50                  55                  60                
 Lys Leu Trp Met Lys Glu Leu Gln Thr Gln Arg Gly Lys His Ser Gly
  65                  70                  75                  80
 Asp Arg Asn Gln Asn Glu Met Ala Thr Leu His Lys Ala Gly Leu Arg
                  85                  90                  95    
 Cys Phe Ser Leu Gly Glu Leu Ser Cys Trp Gln Ile Lys Arg His Ile
             100                 105                 110        
 Ala Ser Lys Leu Ala Arg Ser Gln Asp Ser Thr Ile Asn Ile Glu Gly
         115                 120                 125            
 Lys Ser Ser Gln Phe Pro Lys His His Asp Ser Pro Cys Gln Val Gly
     130                 135                 140                
 Ala Gly Glu Ser Ile Gln Ala Ser Val Asp Asp Asn Cys Leu Val Asn
 145                 150                 155                 160
 His Ile Gly Asp His Ser Ser Ile Ile Glu Asn Gln Glu Phe Pro Thr
                 165                 170                 175    
 Gly Lys Val Pro Asn Ser Trp Ser Lys Ile Tyr Leu Asn Glu Thr Gln
             180                 185                 190        
 Asn Tyr Gln Arg Ser Cys Lys Gln Thr Gln Met Lys Asn Lys Leu Cys
         195                 200                 205            
 Ile Phe Ala Pro Tyr Val Asp Ile Phe Ser Cys Ile Ser His His His
     210                 215                 220                
 Asp Asp Asn Ile Val His Lys Arg Asp Lys Val His Ser Asn Ser Asp
 225                 230                 235                 240
 Cys Gly Lys Asp Thr Leu Lys Val Ser Pro Leu Thr Gln Arg Ser Ile
                 245                 250                 255    
 His Thr Gly Gln Lys Thr Tyr Gln Gly Asn Glu Cys Glu Glu Ala Phe
             260                 265                 270        
 Asn Asp Ser Ser Ser Leu Glu Leu His Lys Gln Val His Leu Gly Lys
         275                 280                 285            
 Lys Ser Pro Ala Cys Ser Thr His Glu Lys Asp Thr Ser Tyr Ser Ser
     290                 295                 300                
 Gly Ile Pro Val Gln Gln Ser Val Arg Thr Gly Lys Lys Arg Tyr Trp
 305                 310                 315                 320
 Cys His Glu Cys Gly Lys Gly Phe Ser Gln Ser Ser Asn Leu Gln Thr
                 325                 330                 335    
 His Gln Arg Val His Thr Gly Glu Lys Pro Tyr Thr Cys His Glu Cys
             340                 345                 350        
 Gly Lys Ser Phe Asn Gln Ser Ser His Leu Tyr Ala His Leu Pro Ile
         355                 360                 365            
 His Thr Gly Glu Lys Pro Tyr Arg Cys Asp Ser Cys Gly Lys Gly Phe
     370                 375                 380                
 Ser Arg Ser Thr Asp Leu Asn Ile His Cys Arg Val His Thr Gly Glu
 385                 390                 395                 400
 Lys Pro Tyr Lys Cys Glu Val Cys Gly Lys Gly Phe Thr Gln Arg Ser
                 405                 410                 415    
 His Leu Gln Ala His Glu Arg Ile His Thr Gly Glu Lys Pro Tyr Lys
             420                 425                 430        
 Cys Gly Asp Cys Gly Lys Arg Phe Ser Cys Ser Ser Asn Leu His Thr
         435                 440                 445            
 His Gln Arg Val His Thr Glu Glu Lys Pro Tyr Lys Cys Asp Glu Cys
     450                 455                 460                
 Gly Lys Cys Phe Ser Leu Ser Phe Asn Leu His Ser His Gln Arg Val
 465                 470                 475                 480
 His Thr Gly Glu Lys Pro Tyr Lys Cys Glu Glu Cys Gly Lys Gly Phe
                 485                 490                 495    
 Ser Ser Ala Ser Ser Phe Gln Ser His Gln Ser Ala Arg Gly Gln Ile
             500                 505                 510        
 Phe Lys Ser Ile Arg
         515        



      <210> 1296
      <211> 549
      <212> PRT
      <213> Homo sapiens


      <400> 1296
 Met Ala Ala Gln Leu Leu Thr Asp Glu Ala Leu Glu Ser Val Thr Phe
   1               5                  10                  15    
 Arg Asp Val Thr Val Asp Phe Thr Gln Glu Glu Trp Gln Gln Leu Glu
              20                  25                  30        
 Pro Ala Gln Lys Asp Leu Tyr Arg Asp Val Met Leu Glu Asn Tyr Arg
          35                  40                  45            
 Asn Leu Val Ser Leu Asp Trp Glu Thr Arg Pro Glu Met Lys Glu Leu
      50                  55                  60                
 Asp Pro Lys Asn Asp Ile Ser Glu Asp Lys Leu Ser Val Val Gly Glu
  65                  70                  75                  80
 Ala Thr Gly Gly Pro Thr Arg Asn Gly Ala Arg Gly Pro Gly Ser Glu
                  85                  90                  95    
 Gly Val Trp Glu Pro Gly Ser Trp Pro Glu Arg Pro Arg Gly Asp Ala
             100                 105                 110        
 Gly Ala Glu Trp Glu Pro Leu Gly Ile Pro Gln Gly Asn Lys Leu Leu
         115                 120                 125            
 Gly Gly Ser Val Pro Ala Cys His Glu Leu Lys Ala Phe Ala Asn Gln
     130                 135                 140                
 Gly Cys Val Leu Val Pro Pro Arg Leu Asp Asp Pro Thr Glu Lys Gly
 145                 150                 155                 160
 Ala Cys Pro Pro Val Arg Arg Gly Lys Asn Phe Ser Ser Thr Ser Asp
                 165                 170                 175    
 Leu Ser Lys Pro Pro Met Pro Cys Glu Glu Lys Lys Thr Tyr Asp Cys
             180                 185                 190        
 Ser Glu Cys Gly Lys Ala Phe Ser Arg Ser Ser Ser Leu Ile Lys His
         195                 200                 205            
 Gln Arg Ile His Thr Gly Glu Lys Pro Phe Glu Cys Asp Thr Cys Gly
     210                 215                 220                
 Lys His Phe Ile Glu Arg Ser Ser Leu Thr Ile His Gln Arg Val His
 225                 230                 235                 240
 Thr Gly Glu Lys Pro Tyr Ala Cys Gly Asp Cys Gly Lys Ala Phe Ser
                 245                 250                 255    
 Gln Arg Met Asn Leu Thr Val His Gln Arg Thr His Thr Gly Glu Lys
             260                 265                 270        
 Pro Tyr Val Cys Asp Val Cys Gly Lys Ala Phe Arg Lys Thr Ser Ser
         275                 280                 285            
 Leu Thr Gln His Glu Arg Ile His Thr Gly Glu Lys Pro Tyr Ala Cys
     290                 295                 300                
 Gly Asp Cys Gly Lys Ala Phe Ser Gln Asn Met His Leu Ile Val His
 305                 310                 315                 320
 Gln Arg Thr His Thr Gly Glu Lys Pro Tyr Val Cys Pro Glu Cys Gly
                 325                 330                 335    
 Arg Ala Phe Ser Gln Asn Met His Leu Thr Glu His Gln Arg Thr His
             340                 345                 350        
 Thr Gly Glu Lys Pro Tyr Ala Cys Lys Glu Cys Gly Lys Ala Phe Asn
         355                 360                 365            
 Lys Ser Ser Ser Leu Thr Leu His Gln Arg Asn His Thr Gly Glu Lys
     370                 375                 380                
 Pro Tyr Val Cys Gly Glu Cys Gly Lys Ala Phe Ser Gln Ser Ser Tyr
 385                 390                 395                 400
 Leu Ile Gln His Gln Arg Phe His Ile Gly Val Lys Pro Phe Glu Cys
                 405                 410                 415    
 Ser Glu Cys Gly Lys Ala Phe Ser Lys Asn Ser Ser Leu Thr Gln His
             420                 425                 430        
 Gln Arg Ile His Thr Gly Glu Lys Pro Tyr Glu Cys Tyr Ile Cys Lys
         435                 440                 445            
 Lys His Phe Thr Gly Arg Ser Ser Leu Ile Val His Gln Ile Val His
     450                 455                 460                
 Thr Gly Glu Lys Pro Tyr Val Cys Gly Glu Cys Gly Lys Ala Phe Ser
 465                 470                 475                 480
 Gln Ser Ala Tyr Leu Ile Glu His Gln Arg Ile His Thr Gly Glu Lys
                 485                 490                 495    
 Pro Tyr Arg Cys Gly Gln Cys Gly Lys Ser Phe Ile Lys Asn Ser Ser
             500                 505                 510        
 Leu Thr Val His Gln Arg Ile His Thr Gly Glu Lys Pro Tyr Arg Cys
         515                 520                 525            
 Gly Glu Cys Gly Lys Thr Phe Ser Arg Asn Thr Asn Leu Thr Arg His
     530                 535                 540                
 Leu Arg Ile His Thr
 545                



      <210> 1297
      <211> 218
      <212> PRT
      <213> Homo sapiens


      <400> 1297
 Met Ile Ser Val Val Val Ile Arg Met Leu Val Glu Ile His Thr Val
   1               5                  10                  15    
 Lys Ala Ile Leu Asp Pro Pro Val Phe His Thr Gly Gln Ile Gly Arg
              20                  25                  30        
 Gly Thr Ser Asn Gly Phe Gln Leu Ala His Asn Ser Gly Pro His Pro
          35                  40                  45            
 Thr Arg Gln Glu Thr Asn Val Gly Thr Gln Pro Val Ala Glu Tyr Ser
      50                  55                  60                
 Cys Ala Gln His Glu Asp Ala Leu Val Lys Asn Gly Tyr Met Asp Ala
  65                  70                  75                  80
 Ser Leu Thr Pro Trp Leu Phe Arg Lys Val Trp Gly Gln Ala Cys Cys
                  85                  90                  95    
 Thr Tyr Cys Phe Gly Leu Met Ile Gln Arg Val Lys Gly Ala Phe Ser
             100                 105                 110        
 Pro Glu Glu Gly Ala Lys Ala Phe Ala Gly Asp Asp Thr Leu Thr Lys
         115                 120                 125            
 Val Ser His Ala Leu Ser Lys Lys Thr Asp Gly Gln Arg Gly Cys Ile
     130                 135                 140                
 Leu Gly Gly Gly Leu Pro Gly Asn His Val Gly Pro Gly Pro Glu Asn
 145                 150                 155                 160
 His Pro Leu Ala Ser Ser Ser Trp Gln Val Ser Ser Asn Pro Val Leu
                 165                 170                 175    
 Ala Asp Arg Thr Phe Cys Asn Asp Gly Asn Val Leu Tyr Leu Asp Asn
             180                 185                 190        
 Pro Leu Ala Gln Met Thr Thr Gly Tyr Trp Lys Cys Gly His Lys Glu
         195                 200                 205            
 Pro Asn Phe Ser Leu Cys Phe Ile Val Ile
     210                 215            



      <210> 1298
      <211> 119
      <212> PRT
      <213> Homo sapiens


      <400> 1298
 Met Thr Ser Ile Pro Phe Pro Gly Asp Arg Leu Leu Gln Val Asp Gly
   1               5                  10                  15    
 Val Ile Leu Cys Gly Leu Thr His Lys Gln Ala Val Gln Cys Leu Lys
              20                  25                  30        
 Gly Pro Gly Gln Val Ala Arg Leu Val Leu Glu Arg Arg Val Pro Arg
          35                  40                  45            
 Ser Thr Gln Gln Cys Pro Ser Ala Asn Asp Ser Met Gly Asp Glu Arg
      50                  55                  60                
 Thr Ala Val Ser Leu Val Thr Ala Leu Pro Gly Arg Pro Ser Ser Cys
  65                  70                  75                  80
 Val Ser Val Thr Asp Gly Pro Lys Phe Glu Val Lys Leu Lys Lys Asn
                  85                  90                  95    
 Ala Asn Gly Leu Gly Phe Ser Phe Val Gln Met Glu Lys Glu Ser Cys
             100                 105                 110        
 Ser His Leu Lys Val Ile Leu
         115                



      <210> 1299
      <211> 471
      <212> PRT
      <213> Homo sapiens


      <400> 1299
 Met Leu Pro Pro Pro Leu Asp Ser Ala Asp Ala Ile Arg Ala Val Ser
   1               5                  10                  15    
 Val Gly Val Pro Ala Thr Leu Ser Ala Gly Val Val Trp Thr Cys Ala
              20                  25                  30        
 Thr Leu Arg Gln Met Thr Arg Pro Arg Cys Gly Val Thr Asp Thr Asn
          35                  40                  45            
 Ser Tyr Ala Ala Trp Ala Glu Arg Ile Ser Asp Leu Phe Ala Arg His
      50                  55                  60                
 Arg Thr Lys Met Arg Arg Lys Lys Arg Phe Ala Lys Gln Gly Asn Lys
  65                  70                  75                  80
 Trp Tyr Lys Gln His Leu Ser Tyr Arg Leu Val Asn Trp Pro Glu His
                  85                  90                  95    
 Leu Pro Glu Pro Ala Val Arg Gly Ala Val Arg Ala Ala Phe Gln Leu
             100                 105                 110        
 Trp Ser Asn Val Ser Ala Leu Glu Phe Trp Glu Ala Pro Ala Thr Gly
         115                 120                 125            
 Pro Ala Asp Ile Arg Leu Thr Phe Phe Gln Gly Asp His Asn Asp Gly
     130                 135                 140                
 Leu Gly Asn Ala Phe Asp Gly Pro Gly Gly Ala Leu Ala His Ala Phe
 145                 150                 155                 160
 Leu Pro Arg Arg Gly Glu Ala His Phe Asp Gln Asp Glu Arg Trp Ser
                 165                 170                 175    
 Leu Ser Arg Arg Arg Gly Arg Asn Leu Phe Val Val Leu Ala His Glu
             180                 185                 190        
 Ile Gly His Thr Leu Gly Leu Thr His Ser Pro Ala Pro Arg Ala Leu
         195                 200                 205            
 Met Ala Pro Tyr Tyr Lys Arg Leu Gly Arg Asp Ala Leu Leu Ser Trp
     210                 215                 220                
 Asp Asp Val Leu Ala Val Gln Ser Leu Tyr Gly Lys Pro Leu Gly Gly
 225                 230                 235                 240
 Ser Val Ala Val Gln Leu Pro Gly Lys Leu Phe Thr Asp Phe Glu Thr
                 245                 250                 255    
 Trp Asp Ser Tyr Ser Pro Gln Gly Arg Arg Pro Glu Thr Gln Gly Pro
             260                 265                 270        
 Lys Tyr Cys His Ser Ser Phe Asp Ala Ile Thr Val Asp Arg Gln Gln
         275                 280                 285            
 Gln Leu Tyr Ile Phe Lys Gly Ser His Phe Trp Glu Val Ala Ala Asp
     290                 295                 300                
 Gly Asn Val Ser Glu Pro Arg Pro Leu Gln Glu Arg Trp Val Gly Leu
 305                 310                 315                 320
 Pro Pro Asn Ile Glu Ala Ala Ala Val Ser Leu Asn Asp Gly Asp Phe
                 325                 330                 335    
 Tyr Phe Phe Lys Gly Gly Arg Cys Trp Arg Phe Arg Gly Pro Lys Pro
             340                 345                 350        
 Val Trp Gly Leu Pro Gln Leu Cys Arg Ala Gly Gly Leu Pro Arg His
         355                 360                 365            
 Pro Asp Ala Ala Leu Phe Phe Pro Pro Leu Arg Arg Leu Ile Leu Phe
     370                 375                 380                
 Lys Gly Ala Arg Tyr Tyr Val Leu Ala Arg Gly Gly Leu Gln Val Glu
 385                 390                 395                 400
 Pro Tyr Tyr Pro Arg Ser Leu Gln Asp Trp Gly Gly Ile Pro Glu Glu
                 405                 410                 415    
 Val Ser Gly Ala Leu Pro Arg Pro Asp Gly Ser Ile Ile Phe Phe Arg
             420                 425                 430        
 Asp Asp Arg Tyr Trp Arg Leu Asp Gln Ala Lys Leu Gln Ala Thr Thr
         435                 440                 445            
 Ser Gly Arg Trp Ala Thr Glu Leu Pro Trp Met Gly Cys Trp His Ala
     450                 455                 460                
 Asn Ser Gly Ser Ala Leu Phe
 465                 470    



      <210> 1300
      <211> 48
      <212> PRT
      <213> Homo sapiens


      <400> 1300
 Met Ala Ala Glu Pro Val Glu Asp Asn Cys Ile Asn Phe Val Ala Met
   1               5                  10                  15    
 Lys Phe Ile Asp Asn Thr Leu Tyr Phe Ile Gly Lys Ala Asn Ala Ile
              20                  25                  30        
 Glu Gln Ile Pro Gly Ser Asp Lys Ser Ile Gln Leu Glu Lys Met Leu
          35                  40                  45            





      <210> 1301
      <211> 231
      <212> PRT
      <213> Homo sapiens


      <400> 1301
 Met Ser Leu Trp Thr Arg Ala Pro Ala Leu Ala Ile Thr Asp Cys Gly
   1               5                  10                  15    
 Asp Leu Lys Val Glu Met Met Ala Gly Gly Thr Gln Ile Thr Pro Leu
              20                  25                  30        
 Asn Asp Asn Val Thr Ile Phe Cys Asn Ile Phe Tyr Ser Gln Pro Leu
          35                  40                  45            
 Asn Ile Thr Ser Met Gly Ile Thr Trp Phe Trp Lys Ser Leu Thr Phe
      50                  55                  60                
 Asp Lys Glu Val Lys Val Phe Glu Phe Phe Gly Asp His Gln Glu Ala
  65                  70                  75                  80
 Phe Arg Pro Gly Ala Ile Val Ser Pro Trp Arg Leu Lys Ser Gly Asp
                  85                  90                  95    
 Ala Ser Leu Arg Leu Pro Gly Ile Gln Leu Glu Glu Ala Gly Glu Tyr
             100                 105                 110        
 Arg Cys Glu Val Val Val Thr Pro Leu Lys Ala Gln Gly Thr Val Gln
         115                 120                 125            
 Leu Glu Val Val Glu Ile Ser Glu Asp Val Ile Thr Gly Pro Thr Ile
     130                 135                 140                
 Lys Asn Met Asp Gly Thr Phe Asn Val Thr Ser Cys Leu Lys Leu Asn
 145                 150                 155                 160
 Ser Ser Gln Glu Asp Pro Gly Thr Val Tyr Gln Cys Val Val Arg His
                 165                 170                 175    
 Ala Ser Leu His Thr Pro Leu Arg Ser Asn Phe Thr Leu Thr Ala Ala
             180                 185                 190        
 Arg His Ser Leu Ser Gly Val Gly Asn Val Gly Cys Val Pro Ile Gln
         195                 200                 205            
 Phe Pro Ile Thr Glu Asp Leu Ala Val Thr Tyr His Leu Thr Ser Val
     210                 215                 220                
 Trp Trp Phe Val Thr Leu Gly
 225                 230    



      <210> 1302
      <211> 84
      <212> PRT
      <213> Homo sapiens


      <400> 1302
 Met Leu Lys Leu Leu Pro Gln Ala Asn Thr Leu Arg Gly Gly Ile His
   1               5                  10                  15    
 Ser Ala Ile Cys Phe Phe Leu Val Gln Pro Gln Pro Leu Ala Ile Arg
              20                  25                  30        
 Glu Val Pro Gly His Gly Leu Leu Ser Arg Arg Glu Gly Arg Arg Trp
          35                  40                  45            
 Leu Ala Trp Arg Pro Arg Arg Leu Leu Arg Leu Arg Ser Ser Ala Ser
      50                  55                  60                
 Gly Ser Ala Gln Pro Gly Ala Arg Ala Ala Pro Arg Asp Ser Arg Arg
  65                  70                  75                  80
 Arg Arg Arg Arg
                



      <210> 1303
      <211> 67
      <212> PRT
      <213> Homo sapiens


      <400> 1303
 Met Asn Leu Leu Ser Arg Cys Trp Ser Cys Asn Leu His His Leu Glu
   1               5                  10                  15    
 Asn Val Val Trp Cys Tyr Ser Phe Pro Ser Ser Thr Leu Lys Phe His
              20                  25                  30        
 Phe Trp Phe Met Ser Ser Tyr Arg Thr Gln Gly Asp Thr Ser Leu Val
          35                  40                  45            
 Phe Ala Arg Glu Val Gly Ser Pro Thr Pro Pro Thr Ser Leu Cys Thr
      50                  55                  60                
 Leu Gln Ile
  65        



      <210> 1304
      <211> 77
      <212> PRT
      <213> Homo sapiens


      <400> 1304
 Met Tyr Asp Cys Met Glu Thr Phe Ala Pro Gly Pro Arg Arg Leu Tyr
   1               5                  10                  15    
 Gly Ala Ala Gly Pro Gly Ala Gly Leu Leu Arg Arg Ala Thr Gly Gly
              20                  25                  30        
 Ser Cys Phe Ala Gly Leu Glu Ser Phe Ala Trp Pro Gln Pro Ala Ser
          35                  40                  45            
 Leu Gln Cys Arg Tyr Arg Ser Pro Gly Leu Gly Cys Arg Val Gln Glu
      50                  55                  60                
 Arg Val Gly Phe Thr Leu Ser Val Cys Lys Glu Trp Asn
  65                  70                  75        



      <210> 1305
      <211> 185
      <212> PRT
      <213> Homo sapiens


      <400> 1305
 Met Ser Ala Phe Asn Leu Leu His Leu Val Thr Lys Ser Gln Pro Val
   1               5                  10                  15    
 Ala Leu Arg Ala Cys Gly Leu Pro Ser Gly Ser Cys Arg Asp Lys Lys
              20                  25                  30        
 Asn Cys Lys Val Val Phe Ser Gln Gln Glu Leu Arg Lys Arg Leu Thr
          35                  40                  45            
 Pro Leu Gln Tyr His Val Thr Gln Glu Lys Gly Thr Glu Ser Ala Phe
      50                  55                  60                
 Glu Gly Glu Tyr Thr His His Lys Asp Pro Gly Ile Tyr Lys Cys Val
  65                  70                  75                  80
 Val Cys Gly Thr Pro Leu Phe Lys Ser Glu Thr Lys Phe Asp Ser Gly
                  85                  90                  95    
 Ser Gly Trp Pro Ser Phe His Asp Val Ile Asn Ser Glu Ala Ile Thr
             100                 105                 110        
 Phe Thr Asp Asp Phe Ser Tyr Gly Met His Arg Val Glu Thr Ser Cys
         115                 120                 125            
 Ser Gln Cys Gly Ala His Leu Gly His Ile Phe Asp Asp Gly Pro Arg
     130                 135                 140                
 Pro Thr Gly Lys Arg Tyr Cys Ile Asn Ser Ala Ala Leu Ser Phe Thr
 145                 150                 155                 160
 Pro Ala Asp Ser Ser Gly Thr Ala Glu Gly Gly Ser Gly Val Ala Ser
                 165                 170                 175    
 Pro Ala Gln Ala Asp Lys Ala Glu Leu
             180                 185



      <210> 1306
      <211> 45
      <212> PRT
      <213> Homo sapiens


      <400> 1306
 Phe Cys Phe Pro Val Gly Phe Gln Gly Thr Ser His Gly Ser Trp Cys
   1               5                  10                  15    
 Ala Ala Pro Val Arg Ser Ala His Cys Leu Ser Ser Met His Thr Gly
              20                  25                  30        
 Leu Thr Ala Ser Arg Val Arg Ser Leu Ala His Leu Leu
          35                  40                  45



      <210> 1307
      <211> 68
      <212> PRT
      <213> Homo sapiens


      <400> 1307
 Met Gly Gln Arg Asp Gln Glu Phe Gln Leu Arg Lys Leu His Glu Gly
   1               5                  10                  15    
 Lys Cys Ile Gln Cys Thr Arg Tyr Ser Glu Ala Cys Thr Met Asp Tyr
              20                  25                  30        
 Thr Leu His Cys Gly Ser Asp Gly Asn Val Tyr Ser Asn Arg Cys Thr
          35                  40                  45            
 Phe Cys Asn Thr Val Val Lys Ser Gln Gly Ala Ile Trp Leu Lys Asn
      50                  55                  60                
 Tyr Gly Leu Cys
  65            



      <210> 1308
      <211> 142
      <212> PRT
      <213> Homo sapiens


      <400> 1308
 Met Cys Pro Pro Gly Leu Leu Val Phe Ala Gly Ser Ser Glu Gln Asp
   1               5                  10                  15    
 Ala Asn Leu Ala Lys Gln Phe Trp Ile Ser Ala Ser Met Tyr Pro Pro
              20                  25                  30        
 Ser Glu Ser Gln Leu Val Leu Arg Arg Asp Ser Ser Gln Arg Leu Pro
          35                  40                  45            
 Val Ala Arg Pro Arg Arg Ser Arg Gly Ser Glu Asn Ser His Ser Ser
      50                  55                  60                
 Gln Ser Phe His Leu Ala Ser Asn Lys Asn Arg Asp Ile Phe Ala Glu
  65                  70                  75                  80
 Ala Leu Lys Ile Gln Glu Ser Glu Glu Lys Val Lys Tyr Leu Gln Lys
                  85                  90                  95    
 Lys Glu Val Thr Val Asp Glu Gln Ser Ile Ala Cys Ser Pro Lys Glu
             100                 105                 110        
 Val Ile Pro Glu Lys Phe Asp Arg Arg Ser Lys Thr Leu Cys Gln Gly
         115                 120                 125            
 Leu Thr Ala Cys Lys Arg Asn Pro Ala Met Gly Ile Gly Met
     130                 135                 140        



      <210> 1309
      <211> 167
      <212> PRT
      <213> Homo sapiens


      <400> 1309
 Met Pro Arg Val Phe Pro Gly Arg Cys Arg Phe His Ser Asp Val Leu
   1               5                  10                  15    
 Leu Gln Cys Thr Leu Val Phe Cys Asn Ser Ser Pro Cys Phe Ser Leu
              20                  25                  30        
 Ser Leu Asp Ala Leu Glu Pro Ser Phe Arg Pro Met Gln Gly Lys Gln
          35                  40                  45            
 Pro Leu Leu Gly Gln Arg Thr Ala Val Cys Pro Leu Trp Ser Pro Cys
      50                  55                  60                
 Leu Ala Arg Gly Ser Val Thr Pro Ala Met Arg Thr Leu Ala Ile Leu
  65                  70                  75                  80
 Ala Ala Ile Leu Leu Val Ala Leu Gln Ala Gln Ala Glu Pro Leu Gln
                  85                  90                  95    
 Ala Arg Ala Asp Glu Val Ala Ala Ala Pro Glu Gln Ile Ala Ala Asp
             100                 105                 110        
 Ile Pro Glu Val Val Val Ser Leu Ala Trp Asp Glu Ser Leu Ala Pro
         115                 120                 125            
 Lys His Pro Gly Ser Arg Lys Asn Met Ala Cys Tyr Cys Arg Ile Pro
     130                 135                 140                
 Ala Cys Ile Ala Gly Glu Arg Arg Tyr Gly Thr Cys Ile Tyr Gln Gly
 145                 150                 155                 160
 Arg Leu Trp Ala Phe Cys Cys
                 165        



      <210> 1310
      <211> 79
      <212> PRT
      <213> Homo sapiens


      <400> 1310
 Met Gln Phe Pro Val Ile Ser Leu Glu Asn Phe Met Ser Leu Phe His
   1               5                  10                  15    
 Tyr Leu Glu Cys Trp Lys Asp Met Ile Arg Ala Ala Cys Ser Ser Gln
              20                  25                  30        
 Lys Ser Val Ser Thr Ile Lys Trp Met Pro Asn His Gln Thr His Lys
          35                  40                  45            
 Cys Ser Arg Cys Val Pro Gly Tyr Gly Ile Ser Arg Tyr Lys Lys Tyr
      50                  55                  60                
 Phe Asn Tyr Ser Phe Val Ile Asn Ile Thr Tyr Glu Lys Lys Ile
  65                  70                  75                



      <210> 1311
      <211> 112
      <212> PRT
      <213> Homo sapiens


      <400> 1311
 Met Ser Asn Asp Val Ser Leu Leu Asp Phe Glu Arg Met Arg Asp Ile
   1               5                  10                  15    
 Leu Leu Ser Leu Leu Met Lys Met Glu Ile Ser Asp Ser Asn Cys Pro
              20                  25                  30        
 Thr Gly Ala Arg Val Ala Ile Val Ser Tyr Asn Ala Lys Thr Asn Tyr
          35                  40                  45            
 Leu Val Arg Phe Ser Asp Tyr Lys Gly Lys Val Ala Leu Leu Glu Ala
      50                  55                  60                
 Val Arg Asn Ile Pro Leu Glu Gln Ser Ser Gly Arg Arg Asn Leu Gly
  65                  70                  75                  80
 Ala Thr Met Arg Phe Met Ala Arg Arg Val Gln Thr Cys Thr Leu Gly
                  85                  90                  95    
 Ser Ser His Glu Glu Gly Gly Cys Val Leu Pro Gly Gly Leu Gly Leu
             100                 105                 110        





      <210> 1312
      <211> 253
      <212> PRT
      <213> Homo sapiens


      <400> 1312
 Met Gly Ala Gly Thr Val Ala Leu Tyr Arg Leu Leu Arg Ala Gln His
   1               5                  10                  15    
 Pro Leu His Trp His Phe Val Phe Ala Gly Pro Met Gln Thr Ala Gln
              20                  25                  30        
 Ala Arg Ser Gly Val Leu Ala Ala Gly Thr Ser Pro Pro Gly Pro Gly
          35                  40                  45            
 Arg Pro Pro Ala Ala Gly Lys Met Pro Glu Gln Ser Asn Asp Tyr Arg
      50                  55                  60                
 Val Val Val Phe Gly Ala Gly Gly Val Gly Lys Ser Ser Leu Val Leu
  65                  70                  75                  80
 Arg Phe Val Lys Gly Thr Phe Arg Asp Thr Tyr Ile Pro Thr Ile Glu
                  85                  90                  95    
 Asp Thr Tyr Arg Gln Val Ile Ser Cys Asp Lys Ser Val Cys Thr Leu
             100                 105                 110        
 Gln Ile Thr Asp Thr Thr Gly Ser His Gln Phe Pro Ala Met Gln Arg
         115                 120                 125            
 Leu Ser Ile Ser Lys Gly His Ala Phe Ile Leu Val Phe Ser Val Thr
     130                 135                 140                
 Ser Lys Gln Ser Leu Glu Glu Leu Gly Pro Ile Tyr Lys Leu Ile Val
 145                 150                 155                 160
 Gln Ile Lys Gly Ser Val Glu Asp Ile Pro Val Met Leu Val Gly Asn
                 165                 170                 175    
 Lys Cys Asp Glu Thr Gln Arg Glu Val Asp Thr Arg Glu Ala Gln Ala
             180                 185                 190        
 Val Ala Gln Glu Trp Lys Cys Ala Phe Met Glu Thr Ser Ala Lys Met
         195                 200                 205            
 Asn Tyr Asn Val Lys Glu Leu Phe Gln Glu Leu Leu Thr Leu Glu Thr
     210                 215                 220                
 Arg Arg Asn Met Ser Leu Asn Ile Asp Gly Lys Arg Ser Gly Lys Gln
 225                 230                 235                 240
 Lys Arg Thr Asp Arg Val Lys Gly Lys Cys Thr Leu Met
                 245                 250            



      <210> 1313
      <211> 120
      <212> PRT
      <213> Homo sapiens


      <400> 1313
 Met Ala Gly Ala Ala Arg Trp Val Gly Gln Glu Ser Ser Ala Met Val
   1               5                  10                  15    
 Cys Phe Gly Cys Pro Gly Gly Ala Ser Ser Arg Cys Arg Ser Pro Arg
              20                  25                  30        
 Gly Arg Gln Ala Ser Arg Val Pro Arg Leu Glu Asn Gly Ala Gln Arg
          35                  40                  45            
 Val Val Arg Thr Met Val His Leu Val Leu Gln Pro Lys Arg Val Thr
      50                  55                  60                
 Leu Val His Pro Pro Arg Gly Leu Glu Pro Val Cys Thr Pro Ile Ala
  65                  70                  75                  80
 Arg Met Arg Pro Lys Ser His Gly Leu Ile Ser Ser Leu Pro Leu Ala
                  85                  90                  95    
 Met Ile Pro Gln Pro Ala Thr Arg Val Ser Arg Pro Gln Ala Leu Trp
             100                 105                 110        
 Lys Arg Leu Tyr Arg His Cys Thr
         115                 120



      <210> 1314
      <211> 382
      <212> PRT
      <213> Homo sapiens


      <400> 1314
 Met Leu Glu Thr Cys Gly Leu Leu Val Ser Leu Gly His Arg Val Pro
   1               5                  10                  15    
 Lys Pro Glu Leu Val His Leu Leu Glu His Gly Gln Glu Leu Trp Ile
              20                  25                  30        
 Val Lys Arg Gly Leu Ser His Ala Thr Cys Ala Gly Asp Arg Ala Gln
          35                  40                  45            
 Val His Thr Arg Glu Pro Thr Thr Tyr Pro Pro Val Leu Ser Glu Arg
      50                  55                  60                
 Ala Phe Leu Arg Gly Ser Leu Thr Leu Glu Ser Ser Thr Ser Ser Asp
  65                  70                  75                  80
 Ser Arg Leu Gly Arg Ala Arg Asp Glu Glu Gly Leu Leu Glu Met Gln
                  85                  90                  95    
 Lys Gly Lys Val Thr Pro Glu Thr Asp Leu His Lys Glu Thr His Leu
             100                 105                 110        
 Gly Lys Val Ser Leu Glu Gly Glu Gly Leu Gly Thr Asp Asp Gly Leu
         115                 120                 125            
 His Ser Arg Ala Leu Gln Glu Trp Leu Ser Ala Asp Val Leu His Glu
     130                 135                 140                
 Cys Asp Ser Gln Gln Pro Gly Lys Asp Ala Leu Ile His Ala Gly Thr
 145                 150                 155                 160
 Asn Pro Tyr Lys Cys Lys Gln Cys Gly Lys Gly Phe Asn Arg Lys Trp
                 165                 170                 175    
 Tyr Leu Val Arg His Gln Arg Val His Thr Gly Met Lys Pro Tyr Glu
             180                 185                 190        
 Cys Asn Ala Cys Gly Lys Ala Phe Ser Gln Ser Ser Thr Leu Ile Arg
         195                 200                 205            
 His Tyr Leu Ile His Thr Gly Glu Lys Pro Tyr Lys Cys Leu Glu Cys
     210                 215                 220                
 Gly Lys Ala Phe Lys Arg Arg Ser Tyr Leu Met Gln His His Pro Ile
 225                 230                 235                 240
 His Thr Gly Glu Lys Pro Tyr Glu Cys Ser Gln Cys Arg Lys Ala Phe
                 245                 250                 255    
 Thr His Arg Ser Thr Phe Ile Arg His Asn Arg Thr His Thr Gly Glu
             260                 265                 270        
 Lys Pro Phe Glu Cys Lys Glu Cys Glu Lys Ala Phe Ser Asn Arg Ala
         275                 280                 285            
 His Leu Ile Gln His Tyr Ile Ile His Thr Gly Glu Lys Pro Tyr Asp
     290                 295                 300                
 Cys Met Ala Cys Gly Lys Ala Phe Arg Cys Ser Ser Glu Leu Ile Gln
 305                 310                 315                 320
 His Gln Arg Ile His Thr Gly Glu Lys Pro Tyr Glu Cys Thr Gln Cys
                 325                 330                 335    
 Gly Lys Ala Phe His Arg Ser Thr Tyr Leu Ile Gln His Ser Val Ile
             340                 345                 350        
 His Thr Gly Glu Met Pro Tyr Lys Cys Ile Glu Cys Gly Lys Ala Phe
         355                 360                 365            
 Lys Arg Arg Ser His Leu Leu Gln His Gln Arg Val His Thr
     370                 375                 380        



      <210> 1315
      <211> 155
      <212> PRT
      <213> Homo sapiens


      <400> 1315
 Met Gly Cys Ser Gly Cys Gly Gly Cys Gly Ser Gly Cys Gly Gly Cys
   1               5                  10                  15    
 Gly Gly Cys Gly Ser Gly Cys Ala Gly Cys Gly Gly Cys Gly Ser Gly
              20                  25                  30        
 Cys Cys Val Pro Val Cys Cys Cys Lys Pro Met Cys Cys Cys Val Pro
          35                  40                  45            
 Ala Cys Ser Cys Ser Ser Cys Gly Cys Gly Ser Cys Gly Gly Ser Lys
      50                  55                  60                
 Gly Gly Cys Gly Ser Tyr Gly Cys Ser Gln Ser Ser Cys Cys Lys Pro
  65                  70                  75                  80
 Cys Cys Cys Ser Ser Gly Cys Gly Ser Ser Cys Cys Gln Ser Ser Cys
                  85                  90                  95    
 Cys Lys Pro Tyr Cys Cys Gln Ser Ser Cys Cys Lys Pro Tyr Cys Cys
             100                 105                 110        
 Gln Ser Ser Cys Cys Lys Pro Cys Ser Cys Phe Ser Gly Cys Gly Ser
         115                 120                 125            
 Ser Cys Cys Gln Ser Ser Cys Tyr Lys Pro Cys Cys Cys Gln Ser Ser
     130                 135                 140                
 Cys Cys Val Pro Val Cys Cys Gln Cys Lys Ile
 145                 150                 155



      <210> 1316
      <211> 177
      <212> PRT
      <213> Homo sapiens


      <400> 1316
 Met Phe Ser Leu Ala Val Arg Val Pro Gly Cys Gly Leu Glu Asn Cys
   1               5                  10                  15    
 Cys Arg Pro Ser Tyr Cys Gln Thr Thr Cys Cys Arg Thr Thr Cys Cys
              20                  25                  30        
 Arg Pro Ser Cys Cys Val Ser Ser Cys Cys Arg Pro Gln Cys Cys Gln
          35                  40                  45            
 Thr Thr Cys Cys Arg Thr Thr Cys Cys His Pro Ser Cys Cys Val Ser
      50                  55                  60                
 Ser Cys Cys Arg Pro Gln Cys Cys Gln Ser Val Cys Cys Gln Pro Thr
  65                  70                  75                  80
 Cys Cys Arg Pro Gln Cys Cys Gln Thr Thr Cys Cys Glu Thr Thr Cys
                  85                  90                  95    
 Cys Arg Thr Thr Cys Cys Arg Pro Ser Cys Cys Val Ser Ser Cys Cys
             100                 105                 110        
 Arg Pro Gln Cys Cys Gln Ser Val Cys Cys Gln Pro Thr Cys Ser Arg
         115                 120                 125            
 Pro Ser Cys Cys Ile Ser Ser Cys Cys Lys Pro Gln Leu Leu Cys Val
     130                 135                 140                
 Cys Val Leu Gln Thr Pro Val Leu Pro Val Cys Val Leu Pro Ala His
 145                 150                 155                 160
 Leu Leu Pro Pro Gln Leu Gln His Leu Gln Leu Leu Pro Pro Leu Leu
                 165                 170                 175    
 Leu
    



      <210> 1317
      <211> 295
      <212> PRT
      <213> Homo sapiens


      <400> 1317
 Met Pro Cys Ser Pro Ser Ala Ser Ser Leu Cys Ala Ala Ser Pro Pro
   1               5                  10                  15    
 Asn Cys Cys His Pro Ser Cys Cys Gln Thr Thr Cys Cys Arg Thr Thr
              20                  25                  30        
 Ser Cys Ser His Ser Cys Ser Val Ser Ser Cys Cys Arg Pro Gln Cys
          35                  40                  45            
 Cys His Ser Val Cys Cys Gln Pro Thr Cys Cys Arg Pro Ser Cys Cys
      50                  55                  60                
 Gln Thr Thr Cys Cys Arg Thr Thr Cys Cys His Pro Ser Cys Cys Val
  65                  70                  75                  80
 Ser Ser Cys Cys Arg Pro Gln Cys Cys His Ser Val Cys Phe Gln Pro
                  85                  90                  95    
 Thr Cys Cys His Pro Ser Cys Cys Ile Ser Ser Ser Cys Cys Pro Ser
             100                 105                 110        
 Cys Cys Cys Gly Gln Asp Leu Cys Gln Glu Thr Cys Cys Cys Pro Ser
         115                 120                 125            
 Cys Cys Gln Thr Thr Cys Cys Arg Thr Thr Cys Tyr Arg Pro Ser Tyr
     130                 135                 140                
 Ser Val Ser Cys Cys Cys Arg Pro Gln Cys Cys Gln Ser Val Cys Cys
 145                 150                 155                 160
 Gln Pro Thr Cys Cys Arg Pro Arg Cys Cys Ile Ser Ser Cys Cys Arg
                 165                 170                 175    
 Pro Ser Cys Cys Val Ser Ser Cys Cys Lys Pro Gln Cys Cys Gln Ser
             180                 185                 190        
 Val Cys Cys Gln Pro Thr Cys Cys His Pro Ser Cys Cys Ile Ser Ser
         195                 200                 205            
 Cys Cys Arg Pro Ser Cys Cys Val Ser Ser Cys Cys Lys Pro Gln Cys
     210                 215                 220                
 Cys Gln Ser Val Cys Cys Gln Pro Thr Cys Cys His Pro Ser Cys Ser
 225                 230                 235                 240
 Ile Ser Ser Cys Cys Arg Pro Ser Cys Cys Glu Ser Ser Cys Cys Arg
                 245                 250                 255    
 Pro Cys Cys Cys Val Arg Pro Val Cys Gly Arg Val Ser Cys His Thr
             260                 265                 270        
 Thr Cys Tyr Arg Pro Thr Cys Val Ile Ser Thr Cys Pro Arg Pro Val
         275                 280                 285            
 Cys Cys Ala Ser Ser Cys Cys
     290                 295



      <210> 1318
      <211> 173
      <212> PRT
      <213> Homo sapiens


      <400> 1318
 Met Gly Cys Cys Gly Cys Ser Gly Gly Cys Gly Ser Gly Cys Gly Gly
   1               5                  10                  15    
 Cys Gly Ser Gly Cys Gly Gly Cys Gly Ser Gly Cys Gly Gly Tyr Gly
              20                  25                  30        
 Ser Gly Cys Gly Gly Cys Gly Ser Ser Cys Cys Val Pro Val Cys Cys
          35                  40                  45            
 Cys Lys Pro Val Cys Cys Cys Val Pro Ala Cys Ser Cys Thr Ser Cys
      50                  55                  60                
 Gly Ser Cys Gly Gly Ser Lys Gly Asp Cys Gly Ser Cys Gly Gly Ser
  65                  70                  75                  80
 Lys Gly Gly Cys Gly Ser Cys Gly Gly Ser Lys Gly Gly Cys Gly Ser
                  85                  90                  95    
 Cys Gly Gly Ser Lys Gly Gly Cys Gly Ser Cys Gly Cys Ser Gln Ser
             100                 105                 110        
 Ser Cys Cys Lys Pro Cys Cys Cys Ser Ser Gly Cys Gly Ser Ser Cys
         115                 120                 125            
 Cys Gln Ser Ser Cys Cys Lys Pro Cys Cys Cys Gln Ser Ser Cys Cys
     130                 135                 140                
 Val Pro Val Cys Cys Gln Ser Ser Cys Cys Lys Pro Cys Cys Cys Gln
 145                 150                 155                 160
 Ser Asn Cys Cys Val Pro Val Cys Cys Gln Cys Lys Ile
                 165                 170            



      <210> 1319
      <211> 232
      <212> PRT
      <213> Homo sapiens


      <400> 1319
 Met Gln Arg Asn Ala Met Tyr Leu Lys Asn Val Ala Glu Thr Ala Cys
   1               5                  10                  15    
 Asn Phe Gln Leu Thr Gln Tyr Gln Ile Ser His Ala Asn Gln Lys Pro
              20                  25                  30        
 Tyr Glu Cys Gln Ile Cys Gly Lys Pro Phe Arg Lys Arg Ala His Leu
          35                  40                  45            
 Thr Gln His Asn Arg Ile His Thr Gly Gly Lys Pro Tyr Glu Cys Lys
      50                  55                  60                
 Glu Cys Gly Lys Val Phe Ile Cys Cys Ser Thr Leu Ile Gln His Lys
  65                  70                  75                  80
 Arg Thr His Thr Ser Glu Lys Pro Tyr Glu Cys Leu Glu Cys Arg Lys
                  85                  90                  95    
 Thr Phe Arg Arg Ser Ala His Leu Ile Arg His Gln Arg Ile His Thr
             100                 105                 110        
 Gly Glu Lys Pro Tyr Lys Cys Lys Gln Cys Trp Lys Ala Phe Ala Ser
         115                 120                 125            
 Ala Ser Asp Leu Thr Arg His Arg Lys Ile His Thr Asp Glu Arg Leu
     130                 135                 140                
 Tyr Glu Cys Thr Glu Cys Gly Lys Ala Phe Asn Asn Arg Ser Thr Leu
 145                 150                 155                 160
 Ile Gln His Gln Arg Ile His Thr Gly Glu Lys Ser Phe Glu Cys Lys
                 165                 170                 175    
 Glu Cys Gly Lys Ala Phe Asn Asn Cys Ser Thr Leu Thr Gln His Gln
             180                 185                 190        
 Arg Thr His Thr Asn Glu Lys Ser Tyr Glu Cys Gln Glu Cys Lys Lys
         195                 200                 205            
 Ala Phe Arg Gln Ser Ala His Leu Thr Gln His Gln Arg Ile His Thr
     210                 215                 220                
 Gly Glu Lys Pro Tyr Glu Cys Lys
 225                 230        



      <210> 1320
      <211> 53
      <212> PRT
      <213> Homo sapiens


      <400> 1320
 Met Gln Thr Ile Lys Cys Val Val Val Gly Asp Glu Ala Ile Gly Lys
   1               5                  10                  15    
 Thr Cys Leu Leu Ile Ser Tyr Thr Thr Asn Val Phe Pro Glu Glu Tyr
              20                  25                  30        
 Ile Pro Pro Leu Ser Leu Thr Ile Ile Ala Ser Arg His Pro Trp Met
          35                  40                  45            
 Gly Lys Ser Leu Ala
      50            



      <210> 1321
      <211> 215
      <212> PRT
      <213> Homo sapiens


      <400> 1321
 Met Ala Ala Ser Thr Met Ser Val Cys Ser Ser Ala Cys Ser Asp Ser
   1               5                  10                  15    
 Trp Gln Val Asp Ala Cys Pro Glu Ser Cys Cys Glu Pro His Cys Cys
              20                  25                  30        
 Ala Leu Ser Cys Cys Ala Leu Ala Pro Cys Leu Thr Leu Val Cys Thr
          35                  40                  45            
 Pro Val Ser Arg Val Ser Ser Pro Cys Cys Gln Ala Ala Cys Glu Pro
      50                  55                  60                
 Ser Pro Cys Gln Ser Gly Cys Thr Ser Ser Cys Thr Pro Ser Cys Cys
  65                  70                  75                  80
 Gln Gln Ser Ser Cys Gln Pro Ala Cys Cys Thr Ser Ser Pro Cys Gln
                  85                  90                  95    
 Gln Ala Cys Cys Met Pro Val Cys Cys Lys Pro Val Cys Cys Leu Pro
             100                 105                 110        
 Thr Cys Ser Lys Asp Ser Ser Ser Cys Cys Gln Gln Ser Ser Cys Gln
         115                 120                 125            
 Pro Thr Cys Cys Ala Ser Ser Ser Ser Gln Gln Ser Cys Cys Val Pro
     130                 135                 140                
 Val Cys Cys Lys Pro Val Cys Cys Ser Glu Ser Ser Ser Ser Cys Cys
 145                 150                 155                 160
 Gln Gln Ser Ser Cys His Pro Ala Cys Cys Thr Ser Ser Pro Cys Gln
                 165                 170                 175    
 Gln Ala Cys Cys Val Pro Val Arg Cys Lys Pro Val Cys Cys Lys Pro
             180                 185                 190        
 Ile Ser Cys Val Pro Val Cys Ser Gly Ala Ser Thr Ser Cys Leu Glu
         195                 200                 205            
 Arg Gly Ser Leu Ala Leu Glu
     210                 215



      <210> 1322
      <211> 52
      <212> PRT
      <213> Homo sapiens


      <400> 1322
 Met Val Ala Ser Leu Val Phe Ser Asp Leu Glu Phe Leu Ala Ser Arg
   1               5                  10                  15    
 Ile Pro Arg Asn Gly Ile Leu Gly His Val Val Ser Val Ile Val Leu
              20                  25                  30        
 Leu Glu Ala Val Gly His Arg Arg Glu Pro Trp Asn Pro Val Thr Ser
          35                  40                  45            
 Val Gln Leu Asn
      50        



      <210> 1323
      <211> 94
      <212> PRT
      <213> Homo sapiens


      <400> 1323
 Met Ala Arg Leu Leu Ser Glu Gly Glu Gln Gly Ile Pro Thr Ala Cys
   1               5                  10                  15    
 Ala Ala Phe Ala His Ser Arg Arg Ala Pro Arg Arg Gly Leu Ala Gly
              20                  25                  30        
 Val Gly Glu Gly Gly Pro Gln Cys Ser Trp Val Asn Tyr Arg Cys Thr
          35                  40                  45            
 Leu Glu Phe Leu Val Ser Leu Leu Gly Thr Asp Leu Ala Arg Gly Arg
      50                  55                  60                
 Gly Asn Ser Ala Ser Gly Pro Thr Ala Pro Ala Asp Ser Lys Gln Leu
  65                  70                  75                  80
 Ser Cys Lys Thr Leu Asp Gly Val Pro Arg Arg Cys Cys Ala
                  85                  90                



      <210> 1324
      <211> 110
      <212> PRT
      <213> Homo sapiens


      <400> 1324
 Met Val Thr Ser Val Thr Pro Pro Gly Leu Pro Leu Val Pro Phe Pro
   1               5                  10                  15    
 Ser Leu Ala Arg Ser Pro Arg Trp Val Gly Thr Val Gly Cys Asp Asn
              20                  25                  30        
 Gly Ser Arg Leu Leu Phe Leu Pro Gly Gly Arg Cys Ala Arg Ile Arg
          35                  40                  45            
 Phe Asn Gln Met Pro Leu Phe Ala Trp Ser Pro Gly Ser Ser Pro Pro
      50                  55                  60                
 Leu Arg Ser Thr Ile Ile Ser Leu Arg Ser Asp Tyr Leu Pro Gly Met
  65                  70                  75                  80
 Ala Ser Gly Leu Ala Glu Ser Leu Gly Ser Leu Arg Asn Glu Arg Trp
                  85                  90                  95    
 Glu Pro Ser Leu Pro Met Phe Leu Pro His Ala Leu Leu Gly
             100                 105                 110



      <210> 1325
      <211> 156
      <212> PRT
      <213> Homo sapiens


      <400> 1325
 Met Gly Trp Ile Leu Ile Ser Val Ser Val Ser Glu Ser Trp Phe Tyr
   1               5                  10                  15    
 Asp Pro Arg Ala Leu Cys Val Leu Gln Thr Arg Val Leu Lys Gln Asp
              20                  25                  30        
 Glu His Arg Thr Val Tyr Thr Lys Gln Lys Thr Pro Glu Ser Thr Cys
          35                  40                  45            
 Pro Leu Pro Val Arg Lys Gln Gly His Ile Ala Asn Asn Gln Met Ile
      50                  55                  60                
 Thr Thr Gln Ser Asp Ser Arg Leu Arg His Cys Thr Lys Leu Pro Leu
  65                  70                  75                  80
 Asn Arg Arg Glu Lys Glu Ser Pro Glu Ile Tyr Leu Ala Lys Leu Thr
                  85                  90                  95    
 Cys Arg Gly Pro Glu Cys Ala Ser Lys Thr Gly Lys Val Ser Ser Leu
             100                 105                 110        
 Cys Phe Phe Pro Cys Leu Ser Asp Gln His Glu Lys Ala Lys Leu Val
         115                 120                 125            
 Leu Leu Thr Pro Leu Gln Arg Asp Leu Thr Asn Ala Glu Gly Ala Val
     130                 135                 140                
 Ala Arg Trp Ser Leu Leu Leu Leu Leu Leu Asp Gly
 145                 150                 155    



      <210> 1326
      <211> 57
      <212> PRT
      <213> Homo sapiens


      <400> 1326
 Met Cys Asn Met Leu Thr Asp Val Leu Ala Leu Pro Met Leu Ser Asp
   1               5                  10                  15    
 Ser Thr Met Leu Ser Asp Ser Ser Gly Pro Ser His Ala Leu Ala Arg
              20                  25                  30        
 Gly Arg Ser Gly Arg Ala Met Leu Thr Gly Ala Ala Glu Ser Gln Gln
          35                  40                  45            
 Pro Phe Ser Arg Glu Gly Val Ser Arg
      50                  55        



      <210> 1327
      <211> 196
      <212> PRT
      <213> Homo sapiens


      <400> 1327
 Met Gly Phe Arg Ala Cys His Thr Cys Cys Pro Cys Thr Gln Met Gly
   1               5                  10                  15    
 Phe Gly Ala Cys His Thr Cys Cys Ser Cys Thr Gln Thr Gly Ser Trp
              20                  25                  30        
 Ala Tyr His Pro Cys Cys Pro Cys Thr Gln Met Gly Phe Gly Ala Cys
          35                  40                  45            
 His Thr Cys Cys Pro Tyr Gly Phe Arg Ala Cys His Thr Cys Cys Ser
      50                  55                  60                
 Cys Thr Gln Thr Gly Ser Trp Ala Cys His Thr Cys Cys Pro Cys Thr
  65                  70                  75                  80
 Gln Met Gly Phe Gly Ala Cys His Thr Cys Gly Pro Cys Thr Gln Met
                  85                  90                  95    
 Gly Phe Gly Ala Cys His Thr Cys Cys Pro Cys Thr Gln Met Gly Phe
             100                 105                 110        
 Gly Ala Cys His Thr Cys Cys Pro Cys Ala Gln Met Gly Phe Gly Ala
         115                 120                 125            
 Cys His Thr Cys Cys Pro Cys Ala Gln Met Gly Phe Gly Ala Cys His
     130                 135                 140                
 Thr Cys Cys Pro Cys Ala Gln Met Gly Phe Gly Ala Cys His Thr Cys
 145                 150                 155                 160
 Cys Pro Cys Thr Gln Thr Gly Ser Trp Ala Tyr His Val Cys Cys Leu
                 165                 170                 175    
 Cys Lys Gln Ser Gly Ser Gln Asp Tyr His Ala Cys Cys Pro Cys Thr
             180                 185                 190        
 Gln Ala Gly Ser
         195    



      <210> 1328
      <211> 110
      <212> PRT
      <213> Homo sapiens


      <400> 1328
 Met Gly Thr Arg Cys Gln Leu Leu Ala Pro Ser Thr Pro Ile Ala Arg
   1               5                  10                  15    
 Ala Ala Gly Thr Cys Arg Val Ala Glu Leu Gly Arg Thr His Pro Ile
              20                  25                  30        
 Thr Met Ser Thr Val Val Leu Leu Leu Gln Arg Ser Val Ser Asn Ala
          35                  40                  45            
 Ala Thr Arg Val Cys Arg Thr Gly Arg Ser Arg Trp Arg Asp Val Cys
      50                  55                  60                
 Arg Asn Phe Met Arg Arg Tyr Gln Ser Arg Val Thr Gln Gly Leu Val
  65                  70                  75                  80
 Ala Gly Glu Thr Ala Gln Gln Ile Cys Glu Asp Leu Arg Leu Cys Ile
                  85                  90                  95    
 Pro Ser Thr Gly Glu Cys Arg Gly Asp Ser Arg Asp Thr Ser
             100                 105                 110



      <210> 1329
      <211> 120
      <212> PRT
      <213> Homo sapiens


      <400> 1329
 Met Gly Cys Cys Gly Cys Gly Gly Cys Gly Gly Cys Gly Gly Arg Cys
   1               5                  10                  15    
 Gly Gly Cys Gly Gly Gly Cys Gly Gly Gly Cys Gly Gly Gly Cys Gly
              20                  25                  30        
 Gly Gly Cys Gly Gly Gly Cys Gly Gly Gly Cys Gly Gly Gly Cys Gly
          35                  40                  45            
 Gly Gly Cys Gly Gly Ser Cys Gly Ser Cys Thr Thr Cys Arg Cys Tyr
      50                  55                  60                
 Arg Val Gly Cys Cys Ser Ser Cys Cys Pro Cys Cys Arg Gly Cys Cys
  65                  70                  75                  80
 Gly Gly Cys Cys Ser Thr Pro Val Ile Cys Cys Cys Arg Arg Thr Cys
                  85                  90                  95    
 Gly Ser Cys Gly Cys Gly Cys Gly Lys Gly Cys Cys Gln Gln Lys Gly
             100                 105                 110        
 Cys Cys Gln Lys Gln Cys Cys Cys
         115                 120



      <210> 1330
      <211> 319
      <212> PRT
      <213> Homo sapiens


      <400> 1330
 Met Gly Arg Arg Ser Ser Asp Thr Glu Glu Glu Ser Arg Ser Lys Arg
   1               5                  10                  15    
 Lys Lys Lys His Arg Arg Arg Ser Ser Ser Ser Ser Ser Ser Asp Ser
              20                  25                  30        
 Arg Thr Tyr Ser Arg Lys Lys Gly Gly Arg Lys Ser Arg Ser Lys Ser
          35                  40                  45            
 Arg Ser Trp Ser Arg Asp Leu Gln Pro Arg Ser His Ser Tyr Asp Arg
      50                  55                  60                
 Arg Arg Arg His Arg Ser Ser Ser Ser Ser Ser Tyr Gly Ser Arg Arg
  65                  70                  75                  80
 Lys Arg Ser Arg Ser Arg Ser Arg Gly Arg Gly Lys Ser Tyr Arg Val
                  85                  90                  95    
 Gln Arg Ser Arg Ser Lys Ser Arg Thr Arg Arg Ser Arg Ser Arg Pro
             100                 105                 110        
 Arg Leu Arg Ser His Ser Arg Ser Ser Glu Arg Ser Ser His Arg Arg
         115                 120                 125            
 Thr Arg Ser Arg Ser Arg Asp Arg Glu Arg Arg Lys Gly Arg Asp Lys
     130                 135                 140                
 Glu Lys Arg Glu Lys Glu Lys Asp Lys Gly Lys Asp Lys Glu Leu His
 145                 150                 155                 160
 Asn Ile Lys Arg Gly Glu Ser Gly Asn Ile Lys Ala Gly Leu Glu His
                 165                 170                 175    
 Leu Pro Pro Ala Glu Gln Ala Lys Ala Arg Leu Gln Leu Val Leu Glu
             180                 185                 190        
 Ala Ala Ala Lys Ala Asp Glu Ala Leu Lys Ala Lys Glu Arg Asn Glu
         195                 200                 205            
 Glu Glu Ala Lys Arg Arg Lys Glu Glu Asp Gln Ala Thr Leu Val Glu
     210                 215                 220                
 Gln Val Lys Arg Val Lys Glu Ile Glu Ala Ile Glu Ser Asp Ser Phe
 225                 230                 235                 240
 Val Gln Gln Thr Phe Arg Ser Ser Lys Glu Val Lys Lys Ser Gly Gly
                 245                 250                 255    
 Arg Arg Lys Glu Ile Lys Ile Leu Thr Leu Ile Leu Ile Ser Phe Leu
             260                 265                 270        
 Leu Ser Phe Gly Cys Met Phe Tyr Tyr Leu Arg Asn Cys Ser Arg Arg
         275                 280                 285            
 Thr Val Tyr Gly Val Ser Phe Phe Ser Cys Phe Cys Phe Leu Leu Gln
     290                 295                 300                
 Tyr Leu Met Thr Asp Val Pro Phe Leu Trp Ala His Thr Ser Arg
 305                 310                 315                



      <210> 1331
      <211> 242
      <212> PRT
      <213> Homo sapiens


      <400> 1331
 Met Val Ser Gln Ala Asn Arg Thr Val Leu Glu Asn Leu Gly Asn Gly
   1               5                  10                  15    
 Thr Ser Leu Pro Val Leu Glu Gly Gln Ser Leu Arg Leu Val Cys Val
              20                  25                  30        
 Thr His Ser Ser Pro Pro Ala Arg Leu Ser Trp Thr Arg Trp Gly Gln
          35                  40                  45            
 Thr Val Gly Pro Ser Gln Pro Ser Asp Pro Gly Val Leu Glu Leu Pro
      50                  55                  60                
 Pro Ile Gln Met Glu His Glu Gly Glu Phe Thr Cys His Ala Gln His
  65                  70                  75                  80
 Pro Leu Gly Ser Gln His Val Ser Leu Ser Leu Ser Val His Trp Lys
                  85                  90                  95    
 Leu Glu His Gly Gly Gly Leu Gly Leu Gly Ala Ala Leu Gly Ala Gly
             100                 105                 110        
 Val Ala Ala Leu Leu Ala Phe Cys Ser Cys Leu Val Val Phe Arg Val
         115                 120                 125            
 Lys Ile Cys Arg Lys Glu Ala Arg Lys Arg Ala Ala Ala Glu Gln Asp
     130                 135                 140                
 Val Pro Ser Thr Leu Gly Pro Ile Ser Gln Gly His Gln His Glu Cys
 145                 150                 155                 160
 Ser Ala Gly Ser Ser Gln Asp His Pro Pro Pro Gly Ala Ala Thr Tyr
                 165                 170                 175    
 Thr Pro Gly Lys Gly Glu Glu Gln Glu Leu His Tyr Ala Ser Leu Ser
             180                 185                 190        
 Phe Gln Gly Leu Arg Leu Trp Glu Pro Ala Asp Gln Glu Ala Pro Ser
         195                 200                 205            
 Thr Thr Glu Tyr Ser Glu Ile Lys Ile His Thr Gly Gln Pro Leu Arg
     210                 215                 220                
 Gly Pro Gly Phe Gly Leu Gln Leu Glu Arg Glu Met Ser Gly Met Val
 225                 230                 235                 240
 Pro Lys
        



      <210> 1332
      <211> 195
      <212> PRT
      <213> Homo sapiens


      <400> 1332
 Met Ala Gln Leu Cys Gly Leu Arg Arg Ser Arg Ala Phe Leu Ala Leu
   1               5                  10                  15    
 Leu Gly Ser Leu Leu Leu Ser Gly Val Leu Ala Ala Asp Arg Glu Arg
              20                  25                  30        
 Ser Ile His Glu Asn Ala Thr Gly Asp Leu Ala Thr Ser Arg Asn Ala
          35                  40                  45            
 Ala Asp Ser Ser Val Pro Ser Ala Pro Arg Arg Gln Asp Ser Glu Asp
      50                  55                  60                
 His Ser Ser Asp Met Phe Asn Tyr Glu Glu Tyr Cys Thr Ala Asn Ala
  65                  70                  75                  80
 Val Thr Gly Pro Cys Arg Ala Ser Phe Pro Arg Trp Tyr Phe Asp Val
                  85                  90                  95    
 Glu Arg Asn Ser Cys Asn Asn Phe Ile Tyr Gly Gly Cys Arg Gly Asn
             100                 105                 110        
 Lys Asn Ser Tyr Arg Ser Glu Glu Ala Cys Met Leu Arg Cys Phe Arg
         115                 120                 125            
 Gln Gln Glu Asn Pro Pro Leu Pro Leu Gly Ser Lys Val Val Val Leu
     130                 135                 140                
 Ala Gly Leu Phe Val Met Val Leu Ile Leu Phe Leu Gly Ala Ser Met
 145                 150                 155                 160
 Val Tyr Leu Ile Arg Val Ala Arg Arg Asn Gln Glu Arg Ala Leu Arg
                 165                 170                 175    
 Thr Val Trp Ser Ser Gly Asp Asp Lys Glu Gln Leu Val Lys Asn Thr
             180                 185                 190        
 Tyr Val Leu
         195



      <210> 1333
      <211> 614
      <212> PRT
      <213> Homo sapiens


      <400> 1333
 Met Ala Gln Glu Ser Val Met Phe Ser Asp Val Ser Val Asp Phe Ser
   1               5                  10                  15    
 Gln Glu Glu Trp Glu Cys Leu Asn Asp Asp Gln Arg Asp Leu Tyr Arg
              20                  25                  30        
 Asp Val Met Leu Glu Asn Tyr Ser Asn Leu Val Ser Met Gly His Ser
          35                  40                  45            
 Ile Ser Lys Pro Asn Val Ile Ser Tyr Leu Glu Gln Gly Lys Glu Pro
      50                  55                  60                
 Trp Leu Ala Asp Arg Glu Leu Thr Arg Gly Gln Trp Pro Val Leu Glu
  65                  70                  75                  80
 Ser Arg Cys Glu Thr Lys Lys Leu Phe Leu Lys Lys Glu Ile Tyr Glu
                  85                  90                  95    
 Ile Glu Ser Thr Gln Trp Glu Ile Met Glu Lys Leu Thr Arg Arg Asp
             100                 105                 110        
 Phe Gln Cys Ser Ser Phe Arg Asp Asp Trp Glu Cys Asn Arg Gln Phe
         115                 120                 125            
 Lys Lys Glu Leu Gly Ser Gln Gly Gly His Phe Asn Gln Leu Val Phe
     130                 135                 140                
 Thr His Glu Asp Leu Pro Thr Leu Ser His His Pro Ser Phe Thr Leu
 145                 150                 155                 160
 Gln Gln Ile Ile Asn Ser Lys Lys Lys Phe Cys Ala Ser Lys Glu Tyr
                 165                 170                 175    
 Arg Lys Thr Phe Arg His Gly Ser Gln Phe Ala Thr His Glu Ile Ile
             180                 185                 190        
 His Thr Ile Glu Lys Pro Tyr Glu Cys Lys Glu Cys Gly Lys Ser Phe
         195                 200                 205            
 Arg His Pro Ser Arg Leu Thr His His Gln Lys Ile His Thr Gly Lys
     210                 215                 220                
 Lys Pro Phe Glu Cys Lys Glu Cys Gly Lys Thr Phe Ile Cys Gly Ser
 225                 230                 235                 240
 Asp Leu Thr Arg His His Arg Ile His Thr Gly Glu Lys Pro Tyr Glu
                 245                 250                 255    
 Cys Lys Glu Cys Gly Lys Ala Phe Ser Ser Gly Ser Asn Phe Thr Arg
             260                 265                 270        
 His Gln Arg Ile His Thr Gly Glu Lys Pro Tyr Glu Cys Lys Glu Cys
         275                 280                 285            
 Gly Lys Ala Phe Ser Ser Gly Ser Asn Phe Thr Gln His Gln Arg Ile
     290                 295                 300                
 His Thr Gly Glu Lys Pro Tyr Glu Cys Lys Glu Cys Gly Asn Ala Phe
 305                 310                 315                 320
 Ser Gln Ser Ser Gln Leu Ile Lys His Gln Arg Ile His Thr Gly Glu
                 325                 330                 335    
 Lys Pro Tyr Glu Cys Lys Glu Cys Glu Lys Ala Phe Arg Ser Gly Ser
             340                 345                 350        
 Asp Leu Thr Arg His Gln Arg Ile His Thr Gly Glu Lys Pro Tyr Glu
         355                 360                 365            
 Cys Lys Ile Cys Gly Lys Ala Tyr Ser Gln Ser Ser Gln Leu Ile Ser
     370                 375                 380                
 His His Arg Ile His Thr Arg Pro Gly Pro Phe Leu Gly Ile Ile Gly
 385                 390                 395                 400
 Ile Phe Gly Ile Gly Gly Ser Leu Leu Glu Tyr Arg Ala Ser Leu Leu
                 405                 410                 415    
 Ala Gly His Gly Phe Ala Thr Phe Ala Leu Ala Cys Tyr Asn Phe Glu
             420                 425                 430        
 Asp Leu Pro Lys Asn Val Asp Asn Ile Pro Leu Glu Tyr Phe Glu Glu
         435                 440                 445            
 Ala Leu Cys Tyr Met Leu Gln His Pro Gln Val Lys Gly Pro Gly Thr
     450                 455                 460                
 Gly Leu Trp Gly Ile Ser Leu Gly Ala Asp Ile Cys Leu Ser Met Ala
 465                 470                 475                 480
 Ser Phe Leu Lys Asn Asp Ser Asp Thr Val Ser Ile Asn Gly Ser Gly
                 485                 490                 495    
 Ile Ser Gly Asn Arg Gly Ile Asn Cys Lys Gln Asn Ser Ile Pro Pro
             500                 505                 510        
 Leu Gly Tyr Asp Leu Arg Arg Ile Lys Val Ala Phe Ser Gly Leu Val
         515                 520                 525            
 Asp Val Val Asp Ile Lys Asn Asp Leu Val Gly Gly Tyr Lys Asn Pro
     530                 535                 540                
 Ser Met Ile Ser Met Glu Lys Ala Gln Gly Pro Ile Ile Phe Ile Val
 545                 550                 555                 560
 Gly Gln Asp Asp His Asn Trp Arg Ser Glu Leu Tyr Ala Gln Ser Leu
                 565                 570                 575    
 Asn Gly Tyr Gly Pro Met Glu Arg Lys Asn Pro Arg Ser Ser Val Thr
             580                 585                 590        
 Leu Gly Leu Gly Phe Thr Leu Ser Leu Leu Thr Ser Pro Cys Ala Gln
         595                 600                 605            
 Leu Pro Phe Thr Asn Tyr
     610                



      <210> 1334
      <211> 435
      <212> PRT
      <213> Homo sapiens


      <400> 1334
 Met Leu Leu Gly Gly Pro Pro Arg Ser Pro Arg Ser Gly Thr Ser Pro
   1               5                  10                  15    
 Lys Gly Pro Trp Ser Ser Thr Gly His Val Gln Phe Gly Lys Ser Pro
              20                  25                  30        
 Gln Thr Trp Pro Arg Arg Thr Arg Pro Arg Ser Pro Glu Pro Ala Ala
          35                  40                  45            
 Pro Ser Gly Val Arg Gly Ser Thr Trp Thr Arg Arg Arg Asp Ser Pro
      50                  55                  60                
 Arg Arg Ala Gly Pro Thr Ala Leu Ser Arg Tyr Val Gly His Leu Trp
  65                  70                  75                  80
 Met Gly Arg Arg Pro Pro Ser Pro Glu Ala Arg Gly Pro Val Pro Arg
                  85                  90                  95    
 Ser Ser Ala Ala Ser Arg Ala Arg Arg Ser Leu Ala Ser Pro Gly Ile
             100                 105                 110        
 Ser Pro Gly Pro Leu Thr Ala Thr Ile Gly Gly Ala Val Ala Gly Gly
         115                 120                 125            
 Gly Pro Arg Gln Gly Arg Ala Glu Ala His Lys Glu Val Phe Pro Gly
     130                 135                 140                
 Gln Arg Val Gly Lys Met Ala Ala Pro Met Glu Leu Phe Cys Trp Ser
 145                 150                 155                 160
 Gly Gly Trp Gly Leu Pro Ser Val Asp Leu Asp Ser Leu Ala Val Leu
                 165                 170                 175    
 Thr Tyr Ala Arg Phe Thr Gly Ala Pro Leu Lys Val His Lys Ile Ser
             180                 185                 190        
 Asn Pro Trp Gln Ser Pro Ser Gly Thr Leu Pro Ala Leu Arg Thr Ser
         195                 200                 205            
 His Gly Glu Val Ile Ser Val Pro His Lys Ile Ile Thr His Leu Arg
     210                 215                 220                
 Lys Glu Val His Thr Phe Trp Ile Asp Thr Lys Asn Tyr Val Glu Val
 225                 230                 235                 240
 Thr Arg Lys Trp Tyr Ala Glu Ala Met Pro Phe Pro Leu Asn Phe Phe
                 245                 250                 255    
 Leu Pro Gly Arg Met Gln Arg Gln Tyr Met Glu Arg Leu Gln Leu Leu
             260                 265                 270        
 Thr Gly Glu His Arg Pro Glu Asp Glu Glu Glu Leu Glu Lys Glu Leu
         275                 280                 285            
 Tyr Arg Glu Ala Arg Glu Cys Leu Thr Leu Leu Ser Gln Arg Leu Gly
     290                 295                 300                
 Ser Gln Lys Phe Phe Phe Gly Asp Ala Pro Ala Ser Leu Asp Ala Phe
 305                 310                 315                 320
 Val Phe Ser Tyr Leu Ala Leu Leu Leu Gln Ala Lys Leu Pro Ser Gly
                 325                 330                 335    
 Lys Leu Gln Val His Leu Arg Gly Leu His Asn Leu Cys Ala Tyr Cys
             340                 345                 350        
 Thr His Ile Leu Ser Leu Tyr Phe Pro Trp Asp Gly Ala Glu Val Pro
         355                 360                 365            
 Pro Gln Arg Gln Thr Pro Ala Gly Pro Glu Thr Glu Glu Glu Pro Tyr
     370                 375                 380                
 Arg Arg Arg Asn Gln Ile Leu Ser Val Leu Ala Gly Leu Ala Ala Met
 385                 390                 395                 400
 Val Gly Tyr Ala Leu Leu Ser Gly Ile Val Ser Ile Gln Arg Ala Thr
                 405                 410                 415    
 Pro Ala Arg Ala Pro Gly Thr Arg Thr Leu Gly Met Ala Glu Glu Asp
             420                 425                 430        
 Glu Glu Glu
         435



      <210> 1335
      <211> 96
      <212> PRT
      <213> Homo sapiens


      <400> 1335
 Met Ala Trp Ser Leu Phe Pro Pro Leu Pro Arg Pro Leu Val Ser Met
   1               5                  10                  15    
 Ser Pro Pro His Ala Leu Phe Gln Ile Met Leu Gly Ile Phe Phe Asn
              20                  25                  30        
 Val His Ser Ala Val Leu Ile Glu Asp Val Pro Phe Thr Glu Lys Asp
          35                  40                  45            
 Phe Glu Asn Gly Pro Gln Asn Ile Tyr Asn Leu Tyr Glu Gln Val Ser
      50                  55                  60                
 Tyr Asn Cys Phe Ile Ala Ala Gly Leu Tyr Leu Leu Leu Gly Gly Phe
  65                  70                  75                  80
 Ser Phe Cys Gln Val Arg Leu Asn Lys Arg Lys Glu Tyr Met Val Arg
                  85                  90                  95    





      <210> 1336
      <211> 468
      <212> PRT
      <213> Homo sapiens


      <400> 1336
 Met Phe Gly Ala Leu Lys Lys Glu Pro Phe Gln Lys Val Asn Phe Ser
   1               5                  10                  15    
 Val Pro Gly Leu Val Ser Leu Ile Ser Ser Ile Ser Phe Phe Arg Ser
              20                  25                  30        
 Gly Arg Gly Ala Asn Asn Trp Ile Glu Ile Tyr Asn Phe Val Gln Gln
          35                  40                  45            
 Leu Ala Glu Arg Phe Val Ser Pro Glu Met Arg Leu Ser Phe Ile Val
      50                  55                  60                
 Phe Ser Ser Gln Ala Thr Ile Ile Leu Pro Leu Thr Gly Asp Arg Gly
  65                  70                  75                  80
 Lys Ile Ser Lys Gly Leu Glu Asp Leu Lys Arg Val Ser Pro Val Gly
                  85                  90                  95    
 Glu Thr Tyr Ile His Glu Gly Leu Lys Leu Ala Asn Glu Gln Ile Gln
             100                 105                 110        
 Lys Ala Gly Gly Leu Lys Thr Ser Ser Ile Ile Ile Ala Leu Thr Asp
         115                 120                 125            
 Gly Lys Leu Asp Gly Leu Val Pro Ser Tyr Ala Glu Lys Glu Ala Lys
     130                 135                 140                
 Ile Ser Arg Ser Leu Gly Ala Ser Val Tyr Cys Val Gly Val Leu Asp
 145                 150                 155                 160
 Phe Glu Gln Ala Gln Leu Glu Arg Ile Ala Asp Ser Lys Glu Gln Val
                 165                 170                 175    
 Phe Pro Val Lys Gly Gly Phe Gln Ala Leu Lys Gly Ile Ile Asn Ser
             180                 185                 190        
 Ile Leu Ala Gln Ser Cys Thr Glu Ile Leu Glu Leu Gln Pro Ser Ser
         195                 200                 205            
 Val Cys Val Gly Glu Glu Phe Gln Ile Val Leu Ser Gly Arg Gly Phe
     210                 215                 220                
 Met Leu Gly Ser Arg Asn Gly Ser Val Leu Cys Thr Tyr Thr Val Asn
 225                 230                 235                 240
 Glu Thr Tyr Thr Thr Ser Val Lys Pro Val Ser Val Gln Leu Asn Ser
                 245                 250                 255    
 Met Leu Cys Pro Ala Pro Ile Leu Asn Lys Ala Gly Glu Thr Leu Asp
             260                 265                 270        
 Val Ser Val Ser Phe Asn Gly Gly Lys Ser Val Ile Ser Gly Ser Leu
         275                 280                 285            
 Ile Val Thr Ala Thr Glu Cys Ser Asn Gly Ile Ala Ala Ile Ile Val
     290                 295                 300                
 Ile Leu Val Leu Leu Leu Leu Leu Gly Ile Gly Leu Met Trp Trp Phe
 305                 310                 315                 320
 Trp Pro Leu Cys Cys Lys Val Val Ile Lys Asp Pro Pro Pro Pro Pro
                 325                 330                 335    
 Pro Pro Ala Pro Lys Glu Glu Glu Glu Glu Pro Leu Pro Thr Lys Lys
             340                 345                 350        
 Trp Pro Thr Val Asp Ala Ser Tyr Tyr Gly Gly Arg Gly Val Gly Gly
         355                 360                 365            
 Ile Lys Arg Met Glu Val Arg Trp Gly Asp Lys Gly Ser Thr Glu Glu
     370                 375                 380                
 Gly Ala Arg Leu Glu Lys Ala Lys Asn Ala Val Val Lys Ile Pro Glu
 385                 390                 395                 400
 Glu Thr Glu Glu Pro Ile Arg Pro Arg Pro Pro Arg Pro Lys Pro Thr
                 405                 410                 415    
 His Gln Pro Pro Gln Thr Lys Trp Tyr Thr Pro Ile Lys Gly Arg Leu
             420                 425                 430        
 Asp Ala Leu Trp Ala Leu Leu Arg Arg Gln Tyr Asp Arg Val Ser Leu
         435                 440                 445            
 Met Arg Pro Gln Glu Gly Asp Glu Gly Arg Cys Ile Asn Phe Ser Arg
     450                 455                 460                
 Val Pro Ser Gln
 465            



      <210> 1337
      <211> 488
      <212> PRT
      <213> Homo sapiens


      <400> 1337
 Met Phe Gly Ala Leu Lys Lys Glu Pro Phe Gln Lys Val Asn Phe Ser
   1               5                  10                  15    
 Val Pro Gly Leu Val Ser Leu Ile Ser Ser Ile Ser Phe Phe Arg Ser
              20                  25                  30        
 Gly Arg Gly Ala Asn Asn Trp Ile Glu Ile Tyr Asn Phe Val Gln Gln
          35                  40                  45            
 Leu Ala Glu Arg Phe Val Ser Pro Glu Met Arg Leu Ser Phe Ile Val
      50                  55                  60                
 Phe Ser Ser Gln Ala Thr Ile Ile Leu Pro Leu Thr Gly Asp Arg Gly
  65                  70                  75                  80
 Lys Ile Ser Lys Gly Leu Glu Asp Leu Lys Arg Val Ser Pro Val Gly
                  85                  90                  95    
 Glu Thr Tyr Ile His Glu Gly Leu Lys Leu Ala Asn Glu Gln Ile Gln
             100                 105                 110        
 Lys Ala Gly Gly Leu Lys Thr Ser Ser Ile Ile Ile Ala Leu Thr Asp
         115                 120                 125            
 Gly Lys Leu Asp Gly Leu Val Pro Ser Tyr Ala Glu Lys Glu Ala Lys
     130                 135                 140                
 Ile Ser Arg Ser Leu Gly Ala Ser Val Tyr Cys Val Gly Val Leu Asp
 145                 150                 155                 160
 Phe Glu Gln Ala Gln Leu Glu Arg Ile Ala Asp Ser Lys Glu Gln Val
                 165                 170                 175    
 Phe Pro Val Lys Gly Gly Phe Gln Ala Leu Lys Gly Ile Ile Asn Ser
             180                 185                 190        
 Ile Leu Ala Gln Ser Cys Thr Glu Ile Leu Glu Leu Gln Pro Ser Ser
         195                 200                 205            
 Val Cys Val Gly Glu Glu Phe Gln Ile Val Leu Ser Gly Arg Gly Phe
     210                 215                 220                
 Met Leu Gly Ser Arg Asn Gly Ser Val Leu Cys Thr Tyr Thr Val Asn
 225                 230                 235                 240
 Glu Thr Tyr Thr Thr Ser Val Lys Pro Val Ser Val Gln Leu Asn Ser
                 245                 250                 255    
 Met Leu Cys Pro Ala Pro Ile Leu Asn Lys Ala Gly Glu Thr Leu Asp
             260                 265                 270        
 Val Ser Val Ser Phe Asn Gly Gly Lys Ser Val Ile Ser Gly Ser Leu
         275                 280                 285            
 Ile Val Thr Ala Thr Glu Cys Ser Asn Gly Ile Ala Ala Ile Ile Val
     290                 295                 300                
 Ile Leu Val Leu Leu Leu Leu Leu Gly Ile Gly Leu Met Trp Trp Phe
 305                 310                 315                 320
 Trp Pro Leu Cys Cys Lys Val Val Ile Lys Asp Pro Pro Pro Pro Pro
                 325                 330                 335    
 Pro Pro Ala Pro Lys Glu Glu Glu Glu Glu Pro Leu Pro Thr Lys Lys
             340                 345                 350        
 Trp Pro Thr Val Asp Ala Ser Tyr Tyr Gly Gly Arg Gly Val Gly Gly
         355                 360                 365            
 Ile Lys Arg Met Glu Val Arg Trp Gly Asp Lys Gly Ser Thr Glu Glu
     370                 375                 380                
 Gly Ala Arg Leu Glu Lys Ala Lys Asn Ala Val Val Lys Ile Pro Glu
 385                 390                 395                 400
 Glu Thr Glu Glu Pro Ile Arg Pro Arg Pro Pro Arg Pro Lys Pro Thr
                 405                 410                 415    
 His Gln Pro Pro Gln Thr Lys Trp Tyr Thr Pro Ile Lys Gly Arg Leu
             420                 425                 430        
 Asp Ala Leu Trp Ala Leu Leu Arg Arg Gln Tyr Asp Arg Val Ser Leu
         435                 440                 445            
 Met Arg Pro Gln Glu Gly Asp Glu Gly Arg Cys Ile Asn Phe Ser Arg
     450                 455                 460                
 Val Pro Ser Gln Leu Ile Phe Asn Gln Met Lys Lys Ile Lys Cys Ile
 465                 470                 475                 480
 Ser Glu Ala Phe Gly Arg Ala Ala
                 485            



      <210> 1338
      <211> 477
      <212> PRT
      <213> Homo sapiens


      <400> 1338
 Met Ala Ala Ala Met Pro Leu Ala Leu Leu Val Leu Leu Leu Leu Gly
   1               5                  10                  15    
 Pro Gly Gly Trp Cys Leu Ala Glu Pro Pro Arg Asp Ser Leu Arg Glu
              20                  25                  30        
 Glu Leu Val Ile Thr Pro Leu Pro Ser Gly Asp Val Ala Ala Thr Phe
          35                  40                  45            
 Gln Phe Arg Thr Arg Trp Asp Ser Glu Leu Gln Arg Glu Gly Asp Thr
      50                  55                  60                
 Asp His Tyr Phe Leu Arg Tyr Ala Val Leu Pro Arg Glu Val Val Cys
  65                  70                  75                  80
 Thr Glu Asn Leu Thr Pro Trp Lys Lys Leu Leu Pro Cys Ser Ser Lys
                  85                  90                  95    
 Ala Gly Leu Ser Val Leu Leu Lys Ala Arg Ile Ala Cys Ser Thr Pro
             100                 105                 110        
 Ala Thr Thr Pro Arg Gln Trp His Ile Arg Pro Val Cys Arg Asn Ala
         115                 120                 125            
 Arg Cys Thr Ser Ile Ser Trp Glu Leu Arg Gln Thr Leu Ser Val Val
     130                 135                 140                
 Phe Asp Ala Phe Ile Thr Gly Gln Gly Lys Lys Asp Trp Ser Leu Phe
 145                 150                 155                 160
 Arg Met Phe Ser Arg Thr Leu Thr Glu Pro Cys Pro Leu Ala Ser Glu
                 165                 170                 175    
 Ser Arg Val Tyr Val Asp Ile Thr Thr Tyr Asn Gln Asp Asn Glu Thr
             180                 185                 190        
 Leu Glu Val His Pro Pro Pro Thr Thr Thr Tyr Gln Asp Val Ile Leu
         195                 200                 205            
 Gly Thr Arg Lys Thr Tyr Ala Ile Tyr Asp Leu Leu Asp Thr Ala Met
     210                 215                 220                
 Ile Asn Asn Ser Arg Asn Leu Asn Ile Gln Leu Lys Trp Lys Arg Pro
 225                 230                 235                 240
 Pro Glu Asn Glu Ala Pro Pro Val Pro Phe Leu His Ala Gln Arg Tyr
                 245                 250                 255    
 Val Ser Gly Tyr Gly Leu Gln Lys Gly Glu Leu Ser Thr Leu Leu Tyr
             260                 265                 270        
 Asn Thr His Pro Tyr Arg Ala Phe Pro Val Leu Leu Leu Asp Thr Val
         275                 280                 285            
 Pro Trp Tyr Leu Arg Leu Tyr Val His Thr Leu Thr Ile Thr Ser Lys
     290                 295                 300                
 Gly Lys Glu Asn Lys Pro Ser Tyr Ile His Tyr Gln Pro Ala Gln Asp
 305                 310                 315                 320
 Arg Leu Gln Pro His Leu Leu Glu Met Leu Ile Gln Leu Pro Ala Asn
                 325                 330                 335    
 Ser Val Thr Lys Val Ser Ile Gln Phe Glu Arg Ala Leu Leu Lys Trp
             340                 345                 350        
 Thr Glu Tyr Thr Pro Asp Pro Asn His Gly Phe Tyr Val Ser Pro Ser
         355                 360                 365            
 Val Leu Ser Ala Leu Val Pro Ser Met Val Ala Ala Lys Pro Val Asp
     370                 375                 380                
 Trp Glu Glu Ser Pro Leu Phe Asn Ser Leu Phe Pro Val Ser Asp Gly
 385                 390                 395                 400
 Ser Asn Tyr Phe Val Arg Leu Tyr Thr Glu Pro Leu Leu Val Asn Leu
                 405                 410                 415    
 Pro Thr Pro Asp Phe Ser Met Pro Tyr Asn Val Ile Cys Leu Thr Cys
             420                 425                 430        
 Thr Val Val Ala Val Cys Tyr Gly Ser Phe Tyr Asn Leu Leu Thr Arg
         435                 440                 445            
 Thr Phe His Ile Glu Glu Pro Arg Thr Gly Gly Leu Ala Lys Arg Leu
     450                 455                 460                
 Ala Asn Leu Ile Arg Arg Ala Arg Gly Val Pro Pro Leu
 465                 470                 475        



      <210> 1339
      <211> 231
      <212> PRT
      <213> Homo sapiens


      <400> 1339
 Met Ala Arg Leu Gly Ala Leu Leu Leu Ala Ala Ala Leu Gly Ala Leu
   1               5                  10                  15    
 Leu Ser Phe Ala Leu Leu Ala Ala Ala Val Ala Ser Asp Tyr Trp Tyr
              20                  25                  30        
 Ile Leu Glu Val Ala Asp Ala Gly Asn Gly Ser Ala Trp Pro Gly Arg
          35                  40                  45            
 Ala Glu Leu Leu Ser Ser His Ser Gly Leu Trp Arg Ile Cys Glu Arg
      50                  55                  60                
 Leu Arg Gly Leu Cys Phe Pro Gly Gln Asn Gly Cys Ile Pro Leu Val
  65                  70                  75                  80
 Asp Pro Phe Ala Ser Glu Ser Leu Asp Val Ser Thr Ser Val Gln His
                  85                  90                  95    
 Leu Ile Leu Leu His Arg Ala Val Ile Val Val Leu Pro Leu Ser Leu
             100                 105                 110        
 Val Leu Leu Val Cys Gly Trp Ile Cys Gly Leu Leu Ser Ser Leu Ala
         115                 120                 125            
 Gln Ser Val Ser Leu Leu Leu Phe Thr Gly Cys Tyr Phe Leu Leu Gly
     130                 135                 140                
 Ser Val Leu Thr Leu Ala Gly Val Ser Ile Tyr Ile Ser Tyr Ser His
 145                 150                 155                 160
 Leu Ala Phe Ala Glu Thr Val Gln Gln Tyr Gly Pro Gln His Met Gln
                 165                 170                 175    
 Gly Val Arg Val Ser Phe Gly Trp Ser Met Ala Leu Ala Trp Gly Ser
             180                 185                 190        
 Cys Ala Leu Glu Ala Phe Ser Gly Thr Leu Leu Leu Ser Ala Ala Trp
         195                 200                 205            
 Thr Leu Ser Leu Ser Pro Pro Ile Cys Gly His Leu Ser Pro Gln Gln
     210                 215                 220                
 Val Gly Gly Arg Gly Gly Asp
 225                 230    



      <210> 1340
      <211> 257
      <212> PRT
      <213> Homo sapiens


      <400> 1340
 Met Ala Arg Leu Gly Ala Leu Leu Leu Ala Ala Ala Leu Gly Ala Leu
   1               5                  10                  15    
 Leu Ser Phe Ala Leu Leu Ala Ala Ala Val Ala Ser Asp Tyr Trp Tyr
              20                  25                  30        
 Ile Leu Glu Val Ala Asp Ala Gly Asn Gly Ser Ala Trp Pro Gly Arg
          35                  40                  45            
 Ala Glu Leu Leu Ser Ser His Ser Gly Leu Trp Arg Ile Cys Gly Gln
      50                  55                  60                
 Asn Gly Cys Ile Pro Leu Val Asp Pro Phe Ala Ser Glu Ser Leu Asp
  65                  70                  75                  80
 Val Ser Thr Ser Val Gln His Leu Ile Leu Leu His Arg Ala Val Ile
                  85                  90                  95    
 Val Val Leu Pro Leu Ser Leu Val Leu Leu Val Cys Gly Trp Ile Cys
             100                 105                 110        
 Gly Leu Leu Ser Ser Leu Ala Gln Ser Val Ser Leu Leu Leu Phe Thr
         115                 120                 125            
 Gly Cys Tyr Phe Leu Leu Gly Ser Val Leu Thr Leu Ala Gly Val Ser
     130                 135                 140                
 Ile Tyr Ile Ser Tyr Ser His Leu Ala Phe Ala Glu Thr Val Gln Gln
 145                 150                 155                 160
 Tyr Gly Pro Gln His Met Gln Gly Val Arg Val Ser Phe Gly Trp Ser
                 165                 170                 175    
 Met Ala Leu Ala Trp Gly Ser Cys Ala Leu Glu Ala Phe Ser Gly Thr
             180                 185                 190        
 Leu Leu Leu Ser Ala Ala Trp Thr Leu Ser Leu Ser Pro Pro Ile Cys
         195                 200                 205            
 Gly His Leu Ser Pro Gln Gln Gly Arg Leu Gly Gly Glu Glu Ala Asp
     210                 215                 220                
 Glu Arg Ala Arg Glu Pro Leu Arg Phe Ala Gly Val Gly Gly Lys Glu
 225                 230                 235                 240
 Leu Ser Asp Pro Asp Val Pro Leu Cys Pro Leu Pro Cys Ser Gln Ala
                 245                 250                 255    
 Cys
    



      <210> 1341
      <211> 246
      <212> PRT
      <213> Homo sapiens


      <400> 1341
 Met Ala Pro Lys Val Phe Arg Gln Tyr Trp Asp Ile Pro Asp Gly Thr
   1               5                  10                  15    
 Asp Cys His Arg Lys Ala Tyr Ser Thr Thr Ser Ile Ala Ser Val Ala
              20                  25                  30        
 Gly Leu Thr Ala Ala Ala Tyr Arg Val Thr Leu Asn Pro Pro Gly Thr
          35                  40                  45            
 Phe Leu Glu Gly Val Ala Lys Val Gly Gln Tyr Thr Phe Thr Ala Ala
      50                  55                  60                
 Ala Val Gly Ala Val Phe Gly Leu Thr Thr Cys Ile Ser Ala His Val
  65                  70                  75                  80
 Arg Glu Lys Pro Asp Asp Pro Leu Asn Tyr Phe Leu Gly Gly Cys Ala
                  85                  90                  95    
 Gly Gly Leu Thr Leu Gly Ala Arg Thr His Asn Tyr Gly Ile Gly Ala
             100                 105                 110        
 Ala Ala Cys Val Tyr Phe Gly Ile Ala Ala Ser Leu Val Lys Met Gly
         115                 120                 125            
 Arg Leu Glu Val Cys Glu His Cys Val Glu Gly Asp Arg Ala Arg Asn
     130                 135                 140                
 Leu Ser Ser Cys Met Trp Glu Gln Cys Arg Pro Glu Glu Pro Gly His
 145                 150                 155                 160
 Cys Val Ala Gln Ser Glu Val Val Lys Glu Gly Cys Ser Ile Tyr Asn
                 165                 170                 175    
 Arg Ser Glu Ala Cys Pro Ala Ala His His His Pro Thr Tyr Glu Pro
             180                 185                 190        
 Lys Thr Val Thr Thr Gly Ser Pro Pro Val Pro Glu Ala His Ser Pro
         195                 200                 205            
 Gly Phe Asp Gly Ala Ser Phe Ile Gly Gly Val Val Leu Val Leu Ser
     210                 215                 220                
 Leu Gln Ala Val Ala Phe Phe Val Leu His Phe Leu Lys Ala Lys Asp
 225                 230                 235                 240
 Ser Thr Tyr Gln Thr Leu
                 245    



      <210> 1342
      <211> 241
      <212> PRT
      <213> Homo sapiens


      <400> 1342
 Met Ala Tyr His Ser Gly Tyr Gly Ala His Gly Ser Lys His Arg Ala
   1               5                  10                  15    
 Arg Ala Ala Pro Asp Pro Pro Pro Leu Phe Asp Asp Thr Ser Gly Gly
              20                  25                  30        
 Tyr Ser Ser Gln Pro Gly Gly Tyr Pro Ala Thr Gly Ala Asp Val Ala
          35                  40                  45            
 Phe Ser Val Asn His Leu Leu Gly Asp Pro Met Ala Asn Val Ala Met
      50                  55                  60                
 Ala Tyr Gly Ser Ser Ile Ala Ser His Gly Lys Asp Met Val His Lys
  65                  70                  75                  80
 Glu Leu His Arg Phe Val Ser Val Ser Lys Leu Lys Tyr Phe Phe Ala
                  85                  90                  95    
 Val Asp Thr Ala Tyr Val Ala Lys Lys Leu Gly Leu Leu Val Phe Pro
             100                 105                 110        
 Tyr Thr His Gln Asn Trp Glu Val Gln Tyr Ser Arg Asp Ala Pro Leu
         115                 120                 125            
 Pro Pro Arg Gln Asp Leu Asn Ala Pro Asp Leu Tyr Ile Pro Thr Met
     130                 135                 140                
 Ala Phe Ile Thr Tyr Val Leu Leu Ala Gly Met Ala Leu Gly Ile Gln
 145                 150                 155                 160
 Lys Arg Met Ile Leu Ser Val Leu Thr Gly Leu Leu Phe Gly Ser Asp
                 165                 170                 175    
 Gly Tyr Tyr Val Ala Leu Ala Trp Thr Ser Ser Ala Leu Met Tyr Phe
             180                 185                 190        
 Ile Val Arg Ser Leu Arg Thr Ala Ala Leu Gly Pro Asp Ser Met Gly
         195                 200                 205            
 Gly Pro Val Pro Arg Gln Arg Leu Gln Leu Tyr Leu Thr Leu Gly Ala
     210                 215                 220                
 Ala Ala Phe Gln Pro Leu Ile Ile Tyr Trp Leu Thr Phe His Leu Val
 225                 230                 235                 240
 Arg
    



      <210> 1343
      <211> 359
      <212> PRT
      <213> Homo sapiens


      <400> 1343
 Met Gly Val Ala Ser Pro Gly Leu Ser Leu Pro Gly Ala Gln Ala Gly
   1               5                  10                  15    
 Arg Met Ser Gln Asn Asp Phe Leu Glu Ser Pro Ala Pro Leu Ser Ser
              20                  25                  30        
 Met His Arg Tyr Arg Arg Pro Leu Arg His Ala Ala Ser Ala Met Ser
          35                  40                  45            
 Ile Gly Leu Leu Cys Cys Ala Ala Leu Ser Leu Leu Trp Ala Gly Pro
      50                  55                  60                
 Val Asn Ala Gly Val Thr Gln Thr Pro Lys Phe Gln Val Leu Lys Thr
  65                  70                  75                  80
 Gly Gln Ser Met Thr Leu Gln Cys Ala Gln Asp Met Asn His Glu Tyr
                  85                  90                  95    
 Met Ser Trp Tyr Arg Gln Asp Pro Gly Met Gly Leu Arg Leu Ile His
             100                 105                 110        
 Tyr Ser Val Gly Ala Gly Ile Thr Asp Gln Gly Glu Val Pro Asn Gly
         115                 120                 125            
 Tyr Asn Val Ser Arg Ser Thr Thr Glu Asp Phe Pro Leu Arg Leu Leu
     130                 135                 140                
 Ser Ala Ala Pro Ser Gln Thr Ser Val Tyr Phe Cys Ala Ser Ser Phe
 145                 150                 155                 160
 Pro Arg Gln Pro Ser Tyr Asn Glu Gln Phe Phe Gly Pro Gly Thr Arg
                 165                 170                 175    
 Leu Thr Val Leu Glu Asp Leu Lys Asn Val Phe Pro Pro Glu Val Ala
             180                 185                 190        
 Val Phe Glu Pro Ser Glu Ala Glu Ile Ser His Thr Gln Lys Ala Thr
         195                 200                 205            
 Leu Val Cys Leu Ala Thr Gly Phe Tyr Pro Asp His Val Glu Leu Ser
     210                 215                 220                
 Trp Trp Val Asn Gly Lys Glu Val His Ser Gly Val Ser Thr Asp Pro
 225                 230                 235                 240
 Gln Pro Leu Lys Glu Gln Pro Ala Leu Asn Asp Ser Arg Tyr Cys Leu
                 245                 250                 255    
 Ser Ser Arg Leu Arg Val Ser Ala Thr Phe Trp Gln Asn Pro Arg Asn
             260                 265                 270        
 His Phe Arg Cys Gln Val Gln Phe Tyr Gly Leu Ser Glu Asn Asp Glu
         275                 280                 285            
 Trp Thr Gln Asp Arg Ala Lys Pro Val Thr Gln Ile Val Ser Ala Glu
     290                 295                 300                
 Ala Trp Gly Arg Ala Asp Cys Gly Phe Thr Ser Glu Ser Tyr Gln Gln
 305                 310                 315                 320
 Gly Val Leu Ser Ala Thr Ile Leu Tyr Glu Ile Leu Leu Gly Lys Ala
                 325                 330                 335    
 Thr Leu Tyr Ala Val Leu Val Ser Ala Leu Val Leu Met Ala Met Val
             340                 345                 350        
 Lys Arg Lys Asp Ser Arg Gly
         355                



      <210> 1344
      <211> 1334
      <212> PRT
      <213> Homo sapiens


      <400> 1344
 Met Ser Ala Ala Gly Leu Lys Ile Thr Gly Ser Lys Glu Thr Lys Arg
   1               5                  10                  15    
 Arg Leu Leu Leu Ile Ser Ile Asp Trp Val Tyr Cys Gln Glu Lys Gln
              20                  25                  30        
 Glu Glu Arg Arg Glu Leu Pro Arg Ile Ile Thr Gly Pro Pro Pro Glu
          35                  40                  45            
 Ala Ala Val Val Ala Phe Glu Trp Leu Lys Thr Ser Thr Leu Thr Gly
      50                  55                  60                
 Leu His Pro Gln Leu Pro Leu Ser Leu Pro Gln Pro Glu Cys Ala Leu
  65                  70                  75                  80
 Pro Tyr Leu Val Arg Ala Phe Ser Arg Gly Asp Tyr Met Gly Arg Ile
                  85                  90                  95    
 Gln Glu Val Gly Trp Val Thr Ala Gly Leu Val Ile Trp Ala Gly Thr
             100                 105                 110        
 Cys Tyr Tyr Ile Tyr Lys Phe Thr Lys Gly Arg Ala Gln Ser Val Arg
         115                 120                 125            
 Thr Leu Ala Arg Asn Gly Ser Thr Val Lys Met Glu Thr Val Val Gly
     130                 135                 140                
 Val Gln Ser Gln Thr Leu Ala Ile Asn Glu Ala Glu Ile Lys Thr Lys
 145                 150                 155                 160
 Pro Gln Val Glu Ile Gly Ala Glu Thr Gly Ala Arg Ser Gly Pro Gly
                 165                 170                 175    
 Ala Glu Val Glu Thr Lys Ala Thr Ala Ile Ala Ile His Arg Ala Asn
             180                 185                 190        
 Ser Gln Ala Lys Ala Met Val Gly Ala Glu Pro Glu Thr Gln Ser Glu
         195                 200                 205            
 Ser Lys Val Val Ala Gly Thr Leu Val Met Thr Glu Ala Val Thr Leu
     210                 215                 220                
 Thr Glu Val Lys Ala Lys Ala Arg Glu Val Ala Met Lys Glu Ala Val
 225                 230                 235                 240
 Thr Gln Thr Asp Ala Glu Ala Gly Lys Ile Val Lys Lys Glu Ala Val
                 245                 250                 255    
 Thr Gln Thr Lys Ala Lys Ala Trp Ala Leu Val Ala Lys Thr Glu Ala
             260                 265                 270        
 Lys Arg Glu Ala Met Thr Gln Thr Lys Ala Glu Thr His Ile Leu Ala
         275                 280                 285            
 Glu Lys Glu Thr Glu Ile Asn Arg Val Met Val Thr Gln Ser Glu Thr
     290                 295                 300                
 Leu Ala Val Pro Arg Glu Val Ala Lys Met Gly Ala Thr Asn Lys Thr
 305                 310                 315                 320
 Gly Ile Val Asp Glu Thr Lys Thr Arg Ala Leu Glu Glu Thr Val Ser
                 325                 330                 335    
 Val Ala Lys Thr Gln Ser Glu Ala Arg Pro Gly Ala Thr Val Asp Ala
             340                 345                 350        
 Arg Gly Asn Pro Asn Gly Met Ser Arg Glu Val Ala Gly Val Asp Met
         355                 360                 365            
 Lys Ser Cys Ala Gln Ser Gln Ala Val Thr Lys Ile Gln Gly Asp Asp
     370                 375                 380                
 Met Pro Gly Thr Gly Val Glu Asp Met Gly Asn Cys Lys Thr Met Ser
 385                 390                 395                 400
 Arg Ala Glu Ser Gly Ala Asp Thr Arg Ala Ser Ala Gln Pro Gln Ile
                 405                 410                 415    
 Phe Ala Lys Thr Gln Thr Glu Ala Ile Pro Gly Ala Lys Ile Asp Ala
             420                 425                 430        
 Gly Gly Asn Thr Asn Ala Met Cys Lys Val Gly Ala Gly Ala Asp Val
         435                 440                 445            
 Arg Ala Cys Ile Gln Pro Gln Thr Val Ala Lys Lys Gln Ala Glu Val
     450                 455                 460                
 Thr Ser Gly Ala Arg Val Asp Gly Arg Gly Asn Thr Asn Val Ile Ser
 465                 470                 475                 480
 Lys Ala Ile Thr Gly Ala Asp Met Arg Ala Ala Ala Gln Pro Gln Ala
                 485                 490                 495    
 Val Ala Ser Thr His Ala Glu Ala Met Ser Asp Ala Lys Val Lys Asn
             500                 505                 510        
 Arg Gly Asn Pro Asn Ala Met Thr Lys Ala Gly Ala Lys Ala Asn Leu
         515                 520                 525            
 Arg Ala Asn Ser Gln Val Glu Ala Leu Pro Asp Ala Arg Asp Lys Ser
     530                 535                 540                
 Arg Gly Asn Pro Asn Val Met Ala Lys Val Gly Asp Gly Thr Asp Met
 545                 550                 555                 560
 Leu Ser Cys Thr Gln Pro Gln Leu Val Ala Ser Val Gln Ala Asp Thr
                 565                 570                 575    
 Leu Ser Asp Gly Lys Ile Lys Val Arg Gly Asn Val Asn Thr Met Pro
             580                 585                 590        
 Lys Glu Gly Ala Gly Val Asp Met Lys Ala Gln Gly Met Ala Gln Ser
         595                 600                 605            
 Gln Gly Glu Ala Leu Pro Asn Thr Arg Gly Lys Ala Arg Gly Lys Ala
     610                 615                 620                
 Lys Ala Lys Cys Lys Thr Gly Pro Gly Met Asp Met Lys Thr Cys Thr
 625                 630                 635                 640
 Gln Pro Gln Ala Gly Val Lys Thr Pro Ala Glu Ala Leu Leu Asp Ser
                 645                 650                 655    
 Arg Val Asp Gly Arg Gly Asn Pro Asn Ala Thr Ser Lys Ala Gly Thr
             660                 665                 670        
 Lys Ala Asp Gln Arg Val Cys Gly Gln Pro Leu Val Val Ala Asn Pro
         675                 680                 685            
 Gln Gly Glu Ala Leu Pro Gly Ala Lys Asn Lys Val Lys Gly Asn Pro
     690                 695                 700                
 His Thr Val Leu Lys Val Gly Ala Gly Glu Gly Thr Thr Asp Ser Ala
 705                 710                 715                 720
 Gln Pro Glu Ala Val Val Ser Phe Gln Gly Glu Ala Leu Leu Gly Thr
                 725                 730                 735    
 Lys Asn Lys Val Lys Gly Asn Pro Asn Val Val Leu Lys Ala Glu Val
             740                 745                 750        
 Gly Glu Gly Ala Met Gly Thr Ala Gln Leu Gln Ile Met Ala Ser Ser
         755                 760                 765            
 Lys Gly Glu Ala Leu Leu Asp Ser Lys Asn Lys Val Lys Gly Asn Ser
     770                 775                 780                
 Asn Ala Val Ser Lys Ala Gly Ala Gly Thr Asp Thr Thr Gly Ser Val
 785                 790                 795                 800
 Gln Pro Gln Ile Val Ala Asn Ser Gln Gly Glu Val Leu Pro Gly Ala
                 805                 810                 815    
 Lys Asn Lys Ile Arg Gly Asn Pro Thr Thr Val Pro Asn Ser Gly Val
             820                 825                 830        
 Gly Pro Tyr Thr Thr Asp Ser Ala Arg Leu Gln Ala Val Ala Asn Ser
         835                 840                 845            
 Gln Gly Glu Val Leu Pro Gly Ala Lys Asn Lys Val Lys Ala Asn Leu
     850                 855                 860                
 Asn Ala Val Ser Lys Ala Glu Ala Gly Met Gly Ala Thr Gly Ser Val
 865                 870                 875                 880
 Gln Pro Gln Ala Val Ala Asn Ser His Cys Glu Thr Leu Pro Gly Ala
                 885                 890                 895    
 Lys Asn Lys Val Arg Gly Asn Trp Asn Ala Val Ser Lys Ala Gly Ala
             900                 905                 910        
 Gly Met Asp Thr Arg Gly Ser Ala Gln Pro Gln Ala Val Ala Asn Ser
         915                 920                 925            
 Gln Gly Glu Val Leu Pro Gly Ala Lys Asn Lys Val Lys Gly Asn Pro
     930                 935                 940                
 Asn Val Val Ser Lys Ala Gly Ala Arg Glu Asp Thr Val Gly Ser Thr
 945                 950                 955                 960
 Gln Pro Gln Val Leu Ala Ser Ser Gln Arg Glu Thr Leu Pro Gly Ala
                 965                 970                 975    
 Arg Asn Lys Val Lys Gly Asn Ser Asn Val Val Ser Lys Ala Gly Ala
             980                 985                 990        
 Arg Glu Asp Thr Met Gly Ser Ala Gln Pro Gln Val Val Ala Asn Ser
         995                1000                1005            
 Gln Arg Glu Thr Leu Pro Gly Ala Arg Asn Lys Val Lys Gly Asn Ser
    1010                1015                1020                
 Asn Ala Ile Ser Lys Ala Glu Ala Gly Ala Gly Ile Met Gly Ser Val
1025                1030                1035                1040
 Gln Val Gln Val Val Ala Ser Phe Gln Gly Glu Val Leu Pro Gly Ala
                1045                1050                1055    
 Lys Asn Lys Val Arg Gly Asn Ser Asn Ala Val Pro Lys Ala Glu Ala
            1060                1065                1070        
 Gly Ala Asp Thr Val Gly Ser Ala Gln Pro Gln Ala Val Ala Asn Ser
        1075                1080                1085            
 Gln Ser Glu Thr Leu Leu Gly Ala Arg Asn Lys Val Lys Gly Asn Thr
    1090                1095                1100                
 Ile Ala Val Pro Lys Ala Gly Thr Gly Ala Gly Thr Arg His Ser Ala
1105                1110                1115                1120
 Gln Pro Gln Ile Val Ala Gly Ser Gln Gly Glu Thr Leu Pro Gly Ala
                1125                1130                1135    
 Arg Asp Lys Ser Met Ser Thr Ser Glu Ala Glu Ala Thr Ala Glu Asp
            1140                1145                1150        
 Glu Ala Tyr Ala Lys Pro Glu Ala Glu Ala Met Pro Thr Ser Glu Ser
        1155                1160                1165            
 Glu Gly Gly Ser Gly Thr Gln Ala Cys Arg Lys Thr Gln Pro Asn Ile
    1170                1175                1180                
 His Asp Tyr Tyr Trp Asn Gly Ile Gly Val Glu Asp Trp Ile Ala Ala
1185                1190                1195                1200
 Glu Arg Trp Ile Lys Phe Arg Phe Gln Thr Met Asp Gly Asp Trp Glu
                1205                1210                1215    
 Asn Ser Val Ser Trp Ala Asp Asp Glu Asn Glu Ala Ser Ile Gly Ser
            1220                1225                1230        
 Trp Ser Gly Ala Ser Asp Lys Ala Gly Ile Ile Arg Ser Trp Ala Val
        1235                1240                1245            
 Ala Cys Asp Glu Thr Ser Val Lys Ser Trp Ala Gly Ala Arg Ala Glu
    1250                1255                1260                
 Asn Val Val Gly Met Arg Ser Pro Lys Trp Pro Gly Gly Ser Leu Asn
1265                1270                1275                1280
 Phe Asn Gly Ile Ile Val Glu Phe Pro Thr Gly Ser Ile Ser Pro Phe
                1285                1290                1295    
 Glu Thr Lys Ile Phe Arg Pro Ala Glu His Lys Ile Met Glu Ala Gly
            1300                1305                1310        
 Ser Lys Asn Phe Gly Ser Glu Thr Leu Gly Val Ile Glu Ser Asp Ala
        1315                1320                1325            
 Thr Pro Ile Ser Thr Pro
    1330                



      <210> 1345
      <211> 93
      <212> PRT
      <213> Homo sapiens


      <400> 1345
 Met Tyr Gly Leu Lys Glu Ile Tyr Gln Val Arg Glu Met Ser Asn Val
   1               5                  10                  15    
 Val Phe Ser Leu Lys Ala Val Met Trp Val Leu Phe Tyr Cys Leu Phe
              20                  25                  30        
 Val Cys Cys Cys Ile Leu Phe Ser Leu Leu Phe Ala Leu Gln Asn Ala
          35                  40                  45            
 Leu Gly Lys Gly Trp Phe Leu Ser Leu Leu Val Cys Val Phe Phe Phe
      50                  55                  60                
 Phe Phe Leu Asn Pro Lys Ser Leu Cys Asn Trp Phe Glu Pro Pro Thr
  65                  70                  75                  80
 Gly Ala Gly Pro Tyr Arg Pro Tyr Pro Leu Pro Phe Leu
                  85                  90            



      <210> 1346
      <211> 172
      <212> PRT
      <213> Homo sapiens


      <400> 1346
 Met Gly Tyr Cys Ser Gly Arg Cys Thr Leu Ile Phe Ile Cys Gly Met
   1               5                  10                  15    
 Gln Leu Val Cys Val Leu Glu Arg Gln Ile Phe Asp Phe Leu Gly Tyr
              20                  25                  30        
 Gln Trp Ala Pro Ile Leu Ala Asn Phe Val His Ile Ile Ile Val Ile
          35                  40                  45            
 Leu Gly Leu Phe Gly Thr Ile Gln Tyr Arg Pro Arg Tyr Ile Thr Gly
      50                  55                  60                
 Tyr Ala Val Trp Leu Val Leu Trp Val Thr Trp Asn Val Phe Val Ile
  65                  70                  75                  80
 Cys Phe Tyr Leu Glu Ala Gly Asp Leu Ser Lys Glu Thr Asp Leu Ile
                  85                  90                  95    
 Leu Thr Phe Asn Ile Ser Met His Arg Ser Trp Trp Met Glu Asn Gly
             100                 105                 110        
 Pro Gly Cys Thr Val Thr Ser Val Thr Pro Ala Pro Asp Trp Ala Pro
         115                 120                 125            
 Glu Asp His Arg Tyr Ile Thr Val Ser Gly Cys Leu Leu Glu Tyr Gln
     130                 135                 140                
 Tyr Ile Glu Val Ala His Ser Ser Leu Gln Ile Val Leu Ala Gly Cys
 145                 150                 155                 160
 Thr Thr Phe Ala Met Leu Thr Val Glu His Gln Ser
                 165                 170        



      <210> 1347
      <211> 477
      <212> PRT
      <213> Homo sapiens


      <400> 1347
 Met Leu Leu Leu Leu Leu Leu Leu Pro Leu Leu Trp Gly Thr Lys Gly
   1               5                  10                  15    
 Met Glu Gly Asp Arg Gln Tyr Gly Asp Gly Tyr Leu Leu Gln Val Gln
              20                  25                  30        
 Glu Leu Val Thr Val Gln Glu Gly Leu Cys Val His Val Pro Cys Ser
          35                  40                  45            
 Phe Ser Tyr Pro Gln Asp Gly Trp Thr Asp Ser Asp Pro Val His Gly
      50                  55                  60                
 Tyr Trp Phe Arg Ala Gly Asp Arg Pro Tyr Gln Asp Ala Pro Val Ala
  65                  70                  75                  80
 Thr Asn Asn Pro Asp Arg Glu Val Gln Ala Glu Thr Gln Gly Arg Phe
                  85                  90                  95    
 Gln Leu Leu Gly Asp Ile Trp Ser Asn Asp Cys Ser Leu Ser Ile Arg
             100                 105                 110        
 Asp Ala Arg Lys Arg Asp Lys Gly Ser Tyr Phe Phe Arg Leu Glu Arg
         115                 120                 125            
 Gly Ser Met Lys Trp Ser Tyr Lys Ser Gln Leu Asn Tyr Lys Thr Lys
     130                 135                 140                
 Gln Leu Ser Val Phe Val Thr Ala Leu Thr His Arg Pro Asp Ile Leu
 145                 150                 155                 160
 Ile Leu Gly Thr Leu Glu Ser Gly His Ser Arg Asn Leu Thr Cys Ser
                 165                 170                 175    
 Val Pro Trp Ala Cys Lys Gln Gly Thr Pro Pro Met Ile Ser Trp Ile
             180                 185                 190        
 Gly Ala Ser Val Ser Ser Pro Gly Pro Thr Thr Ala Arg Ser Ser Val
         195                 200                 205            
 Leu Thr Leu Thr Pro Lys Pro Gln Asp His Gly Thr Ser Leu Thr Cys
     210                 215                 220                
 Gln Val Thr Leu Pro Gly Thr Gly Val Thr Thr Thr Ser Thr Val Arg
 225                 230                 235                 240
 Leu Asp Val Ser Tyr Pro Pro Gln Asn Leu Thr Met Thr Val Phe Gln
                 245                 250                 255    
 Gly Asp Gly Thr Ala Ser Thr Thr Leu Arg Asn Gly Ser Ala Leu Ser
             260                 265                 270        
 Val Leu Glu Gly Gln Ser Leu His Leu Val Cys Ala Val Asp Ser Asn
         275                 280                 285            
 Pro Pro Ala Arg Leu Ser Trp Thr Trp Gly Ser Leu Thr Leu Ser Pro
     290                 295                 300                
 Ser Gln Ser Ser Asn Leu Gly Val Leu Glu Leu Pro Arg Val His Val
 305                 310                 315                 320
 Lys Asp Glu Gly Glu Phe Thr Cys Arg Ala Gln Asn Pro Leu Gly Ser
                 325                 330                 335    
 Gln His Ile Ser Leu Ser Leu Ser Leu Gln Asn Glu Tyr Thr Gly Lys
             340                 345                 350        
 Met Arg Pro Ile Ser Gly Val Met Leu Gly Ala Phe Gly Gly Ala Gly
         355                 360                 365            
 Ala Thr Ala Leu Val Phe Leu Ser Phe Cys Ile Ile Phe Val Val Val
     370                 375                 380                
 Arg Ser Cys Arg Lys Lys Ser Ala Arg Pro Ala Val Gly Val Gly Asp
 385                 390                 395                 400
 Thr Gly Met Glu Asp Ala Asn Ala Val Arg Gly Ser Ala Ser Gln Gly
                 405                 410                 415    
 Pro Leu Ile Glu Ser Pro Ala Asp Asp Ser Pro Pro His His Ala Pro
             420                 425                 430        
 Pro Ala Leu Ala Thr Pro Ser Pro Glu Glu Gly Glu Ile Gln Tyr Ala
         435                 440                 445            
 Ser Leu Ser Phe His Lys Ala Arg Pro Gln Tyr Pro Gln Glu Gln Glu
     450                 455                 460                
 Ala Ile Gly Tyr Glu Tyr Ser Glu Ile Asn Ile Pro Lys
 465                 470                 475        



      <210> 1348
      <211> 581
      <212> PRT
      <213> Homo sapiens


      <400> 1348
 Met Leu Leu Pro Leu Leu Leu Ser Ser Leu Leu Gly Gly Ser Gln Ala
   1               5                  10                  15    
 Met Asp Gly Arg Phe Trp Ile Arg Val Gln Glu Ser Val Met Val Pro
              20                  25                  30        
 Glu Gly Leu Cys Ile Ser Val Pro Tyr Ser Phe Ser Tyr Pro Arg Gln
          35                  40                  45            
 Asp Trp Thr Gly Ser Thr Pro Ala Tyr Gly Tyr Trp Phe Lys Ala Val
      50                  55                  60                
 Thr Glu Thr Thr Lys Gly Ala Pro Val Ala Thr Asn His Gln Ser Arg
  65                  70                  75                  80
 Glu Val Glu Met Ser Thr Arg Gly Arg Phe Gln Leu Thr Gly Asp Pro
                  85                  90                  95    
 Ala Lys Gly Asn Cys Ser Leu Val Ile Arg Asp Ala Gln Met Gln Asp
             100                 105                 110        
 Glu Ser Gln Tyr Phe Phe Arg Val Glu Arg Gly Ser Tyr Val Arg Tyr
         115                 120                 125            
 Asn Phe Met Asn Asp Gly Phe Phe Leu Lys Val Thr Ala Leu Thr Gln
     130                 135                 140                
 Lys Pro Asp Val Tyr Ile Pro Glu Thr Leu Glu Pro Gly Gln Pro Val
 145                 150                 155                 160
 Thr Val Ile Cys Val Phe Asn Trp Ala Phe Glu Glu Cys Pro Pro Pro
                 165                 170                 175    
 Ser Phe Ser Trp Thr Gly Ala Ala Leu Ser Ser Gln Gly Thr Lys Pro
             180                 185                 190        
 Thr Thr Ser His Phe Ser Val Leu Ser Phe Thr Pro Arg Pro Gln Asp
         195                 200                 205            
 His Asn Thr Asp Leu Thr Cys His Val Asp Phe Ser Arg Lys Gly Val
     210                 215                 220                
 Ser Val Gln Arg Thr Val Arg Leu Arg Val Ala Tyr Ala Pro Arg Asp
 225                 230                 235                 240
 Leu Val Ile Ser Ile Ser Arg Asp Asn Thr Pro Ala Leu Glu Pro Gln
                 245                 250                 255    
 Pro Gln Gly Asn Val Pro Tyr Leu Glu Ala Gln Lys Gly Gln Phe Leu
             260                 265                 270        
 Arg Leu Leu Cys Ala Ala Asp Ser Gln Pro Pro Ala Thr Leu Ser Trp
         275                 280                 285            
 Val Leu Gln Asn Arg Val Leu Ser Ser Ser His Pro Trp Gly Pro Arg
     290                 295                 300                
 Pro Leu Gly Leu Glu Leu Pro Gly Val Lys Ala Gly Asp Ser Gly Arg
 305                 310                 315                 320
 Tyr Thr Cys Arg Ala Glu Asn Arg Leu Gly Ser Gln Gln Arg Ala Leu
                 325                 330                 335    
 Asp Leu Ser Val Gln Tyr Pro Pro Glu Asn Leu Arg Val Met Val Ser
             340                 345                 350        
 Gln Ala Asn Arg Thr Val Leu Glu Asn Leu Gly Asn Gly Thr Ser Leu
         355                 360                 365            
 Pro Val Leu Glu Gly Gln Ser Leu Cys Leu Val Cys Val Thr His Ser
     370                 375                 380                
 Ser Pro Pro Ala Arg Leu Ser Trp Thr Gln Arg Gly Gln Val Leu Ser
 385                 390                 395                 400
 Pro Ser Gln Pro Ser Asp Pro Gly Val Leu Glu Leu Pro Arg Val Gln
                 405                 410                 415    
 Val Glu His Glu Gly Glu Phe Thr Cys His Ala Arg His Pro Leu Gly
             420                 425                 430        
 Ser Gln His Val Ser Leu Ser Leu Ser Val His Tyr Lys Lys Gly Leu
         435                 440                 445            
 Ile Ser Thr Ala Phe Ser Asn Gly Ala Phe Leu Gly Ile Gly Ile Thr
     450                 455                 460                
 Ala Leu Leu Phe Leu Cys Leu Ala Leu Ile Ile Met Lys Ile Leu Pro
 465                 470                 475                 480
 Lys Arg Arg Thr Gln Thr Glu Thr Pro Arg Pro Arg Phe Ser Arg His
                 485                 490                 495    
 Ser Thr Ile Leu Asp Tyr Ile Asn Val Val Pro Thr Ala Gly Pro Leu
             500                 505                 510        
 Val Ser Val Trp Ala Met Leu Pro Leu Phe Leu Phe Ser Lys Ala Asp
         515                 520                 525            
 Ile Pro Leu Ser Asp Phe Cys Thr Pro Cys Leu Ser Asp Ile Lys Val
     530                 535                 540                
 Gly Lys Ala Pro Ile Val Leu Asn Ser Asn Pro Ala Trp His Leu Leu
 545                 550                 555                 560
 Ala Met Arg Pro Gln Pro Arg His Ser Pro Pro Leu Ser Leu His Phe
                 565                 570                 575    
 Phe Leu Cys Leu Leu
             580    



      <210> 1349
      <211> 339
      <212> PRT
      <213> Homo sapiens


      <400> 1349
 Met Ser Gly Leu Leu Leu Leu Phe Trp Gly Phe Pro Ala Leu Phe Pro
   1               5                  10                  15    
 Glu Ser Pro Cys Trp Leu Leu Ala Thr Gly Gln Val Ala Arg Ala Arg
              20                  25                  30        
 Lys Ile Leu Trp Arg Phe Ala Glu Ala Ser Gly Val Gly Pro Gly Asp
          35                  40                  45            
 Ser Ser Leu Glu Glu Asn Ser Leu Ala Thr Glu Leu Thr Met Leu Ser
      50                  55                  60                
 Ala Arg Ser Pro Gln Pro Arg Tyr His Ser Pro Leu Gly Leu Leu Arg
  65                  70                  75                  80
 Thr Arg Val Thr Trp Arg Asn Gly Leu Ile Leu Gly Phe Ser Ser Cys
                  85                  90                  95    
 Cys Leu His Gly Ala Pro Ser Pro Gly Thr Thr Pro His Trp Gly Phe
             100                 105                 110        
 Cys Val Pro Glu Ser Pro Gly Glu Thr Gly Leu Ser Trp Ala Ser Ala
         115                 120                 125            
 Arg Leu Val Gly Gly Gly Ile Arg Ala Ser Phe Arg Arg Ser Leu Ala
     130                 135                 140                
 Pro Gln Val Pro Thr Phe Tyr Leu Pro Tyr Phe Leu Glu Ala Gly Leu
 145                 150                 155                 160
 Glu Ala Ala Ala Leu Val Phe Leu Leu Leu Thr Ala Asp Cys Cys Gly
                 165                 170                 175    
 Arg Arg Pro Val Leu Leu Leu Gly Thr Met Val Thr Gly Leu Ala Ser
             180                 185                 190        
 Leu Leu Leu Leu Ala Gly Ala Gln Tyr Leu Pro Gly Trp Thr Val Leu
         195                 200                 205            
 Phe Leu Ser Val Leu Gly Leu Leu Ala Ser Arg Ala Val Ser Ala Leu
     210                 215                 220                
 Ser Ser Leu Phe Ala Ala Glu Val Phe Pro Thr Val Ile Arg Gly Ala
 225                 230                 235                 240
 Gly Leu Gly Leu Val Leu Gly Ala Gly Phe Leu Gly Gln Ala Ala Gly
                 245                 250                 255    
 Pro Leu Asp Thr Leu His Gly Arg Gln Gly Phe Phe Leu Gln Gln Val
             260                 265                 270        
 Val Phe Ala Ser Leu Ala Val Leu Ala Leu Leu Cys Val Leu Leu Leu
         275                 280                 285            
 Pro Glu Ser Arg Ser Arg Gly Leu Pro Gln Ser Leu Gln Asp Ala Asp
     290                 295                 300                
 Arg Leu Arg Arg Ser Pro Leu Leu Arg Gly Arg Pro Arg Gln Asp His
 305                 310                 315                 320
 Leu Pro Leu Leu Pro Pro Ser Asn Ser Tyr Trp Ala Gly His Thr Pro
                 325                 330                 335    
 Glu Gln His
            



      <210> 1350
      <211> 675
      <212> PRT
      <213> Homo sapiens


      <400> 1350
 Met Gly Phe Ile Cys Ile Thr Arg Pro Arg Phe Ser Ser Gln Ala Thr
   1               5                  10                  15    
 Leu Glu Glu Phe Tyr Ser Ser Val Thr Leu Arg Asn Val Leu Ile Pro
              20                  25                  30        
 Thr Ala Leu Gly Glu Leu Gln Ser Ser Leu Gly Arg Pro Pro Asn Ala
          35                  40                  45            
 Leu Phe Gln Cys Ala Glu Ala Gln Gly Phe Ser Val Ala Pro Arg Tyr
      50                  55                  60                
 Pro Ala Leu Glu Glu Asn Leu Ser Arg Ala Pro Pro Leu Trp Arg Asp
  65                  70                  75                  80
 Arg Pro Pro Ser Ser Arg Glu Ser Ile Pro Cys Asp Arg Lys Trp Gly
                  85                  90                  95    
 Gly Asp Pro Gly Ser Pro Arg Arg Val Gln Leu Gly Arg Phe Asp Arg
             100                 105                 110        
 Arg Arg Asp Leu Thr Pro Pro Gly Val Gly Val Pro Ser Pro Ser Pro
         115                 120                 125            
 Ser Ala Ala Pro Val Ile Val Ala Met Asp Gly Pro Arg Pro Pro Thr
     130                 135                 140                
 Arg Asp Pro Leu Pro Arg Ala Ser Thr Leu Asp Pro Gly Pro Leu Pro
 145                 150                 155                 160
 Pro Gly Leu Asp Pro Arg Pro Pro Ile Arg Asp Pro Phe Pro Gly Ala
                 165                 170                 175    
 Ser Ile Pro Lys Ser Gln Pro Gly Ser Asp Gln Ala Thr Leu Ser Val
             180                 185                 190        
 Thr Ala Pro Gln Thr His Pro Gln Ser Ser Leu Asn Thr Leu Ile Gln
         195                 200                 205            
 Glu Leu Thr Arg Glu Gln Pro Arg Pro Glu Trp Leu Leu Ser Ala His
     210                 215                 220                
 Thr Ala Ser Gly His Gly Ser Arg Val Phe Arg Glu His Asn Val Phe
 225                 230                 235                 240
 Arg Asp Val Gly Val Ala Ser Leu Val Leu Cys Gly Leu Gln Cys Gly
                 245                 250                 255    
 Leu Ser Gly Ala Val Trp Pro Ser Leu Trp Pro Leu Trp Cys Cys Val
             260                 265                 270        
 Ala Phe Ser Val Ala Ser Leu Val Leu Cys Gly Leu Gln Cys Gly Arg
         275                 280                 285            
 Ser Gly Ala Val Trp Pro Ser Val Trp Pro Leu Trp Cys Cys Val Ala
     290                 295                 300                
 Phe Thr Val Ala Ser Leu Val Leu Cys Gly Leu His Cys Gly Leu Ser
 305                 310                 315                 320
 Gly Ala Val Trp Pro Ser Leu Trp Pro Leu Trp Cys Cys Val Ala Phe
                 325                 330                 335    
 Thr Val Ala Ser Leu Val Leu Cys Gly Leu Gln Cys Gly Arg Ser Gly
             340                 345                 350        
 Ala Val Trp Pro Ser Val Trp Pro Leu Trp Cys Cys Val Ala Phe Ser
         355                 360                 365            
 Val Ala Ser Leu Val Leu Cys Gly Leu Gln Cys Gly Leu Ser Gly Ala
     370                 375                 380                
 Val Trp Pro Ser Val Trp Pro Leu Trp Cys Cys Val Ala Phe Thr Val
 385                 390                 395                 400
 Ala Ser Leu Val Leu Cys Gly Leu Gln Cys Gly Arg Ser Gly Ala Val
                 405                 410                 415    
 Trp Pro Ser Val Trp Pro Leu Trp Cys Cys Val Ala Phe Ser Val Ala
             420                 425                 430        
 Ser Leu Val Leu Cys Gly Leu Gln Cys Gly Arg Ser Gly Ala Val Trp
         435                 440                 445            
 Pro Ser Val Trp Pro Leu Trp Cys Cys Val Ala Phe Ser Val Ala Ser
     450                 455                 460                
 Leu Val Leu Cys Gly Leu Gln Cys Gly Leu Ser Gly Ala Val Trp Pro
 465                 470                 475                 480
 Ser Val Trp Pro Leu Trp Cys Cys Val Ala Phe Thr Val Ala Ser Leu
                 485                 490                 495    
 Val Leu Cys Gly Leu Gln Cys Gly Arg Ser Gly Ala Val Trp Pro Ser
             500                 505                 510        
 Val Trp Pro Leu Trp Cys Cys Val Ala Phe Ser Val Ala Ser Leu Val
         515                 520                 525            
 Leu Cys Gly Leu Gln Cys Gly Ser Asp His Cys Phe Trp Arg Leu Leu
     530                 535                 540                
 Lys Asp Gly Ala Thr Ala Val His Ala Gln Pro Cys Arg Gly Pro Arg
 545                 550                 555                 560
 Pro Gly Phe Val Ala Ser Val His Gly Ser Ala Gln Asp Gly Ala Asp
                 565                 570                 575    
 Ala Val Pro Val Val Gly Lys Ser His Trp Gly Arg Glu Lys Pro Lys
             580                 585                 590        
 Pro Cys Trp Leu Arg Gln Pro Val His Gly Gly Val Leu Arg Thr Pro
         595                 600                 605            
 Glu Pro Pro Gly Arg Ala Gln Val Lys Glu His Trp Arg His Arg Arg
     610                 615                 620                
 Arg Trp Thr Ser Arg Ser Arg Leu Leu Cys Trp Lys Ala Leu Met Gly
 625                 630                 635                 640
 Ser Val Gly Ala Asp His Thr Arg Glu Leu Arg Lys Pro Ser Gly Ser
                 645                 650                 655    
 His Arg Pro Pro Phe Asn Val Val Ile Pro Trp Trp Trp Lys Gln Asp
             660                 665                 670        
 Asp Gly Pro
         675



      <210> 1351
      <211> 124
      <212> PRT
      <213> Homo sapiens


      <400> 1351
 Met Arg Gln Gly Asp Met Gly Leu Leu Ser His His Arg Gly Leu Val
   1               5                  10                  15    
 Met Glu Asp Glu Glu Lys Ala Val Glu Ile Leu Gly Asn Thr Glu Ala
              20                  25                  30        
 Ala His Pro Pro Ser Pro Ile Arg Cys Cys Trp Leu Arg Leu Arg Cys
          35                  40                  45            
 Leu Ala Ala Thr Ser Ile Ile Cys Gly Cys Ser Cys Leu Gly Val Met
      50                  55                  60                
 Ala Leu Val Phe Ala Ile Lys Ala Glu Glu Arg His Lys Ala Gly Arg
  65                  70                  75                  80
 Ser Glu Glu Ala Val Arg Trp Gly Ala Arg Ala Arg Lys Leu Ile Leu
                  85                  90                  95    
 Ala Ser Phe Ala Val Trp Leu Ala Val Leu Ile Leu Gly Pro Leu Leu
             100                 105                 110        
 Leu Trp Leu Leu Ser Tyr Ala Ile Ala Gln Ala Glu
         115                 120                



      <210> 1352
      <211> 186
      <212> PRT
      <213> Homo sapiens


      <400> 1352
 Met Ser Asp Ser Gln Ser Tyr Phe Gln Ala Gly Asn Lys Asp Val Arg
   1               5                  10                  15    
 Leu Glu Pro Ile Trp Leu Glu Gly Val Lys Cys Lys Lys Trp Asp Leu
              20                  25                  30        
 Val Cys Asp Asn Ala Trp Lys Val His Ile Ala Lys Phe Ser Leu Leu
          35                  40                  45            
 Val Gly Leu Ile Phe Gly Tyr Leu Ile Thr Gly Cys Ile Ala Asp Trp
      50                  55                  60                
 Val Gly Arg Arg Pro Val Leu Leu Phe Ser Ile Ile Phe Ile Leu Ile
  65                  70                  75                  80
 Phe Gly Leu Thr Val Ala Leu Ser Val Asn Val Thr Met Phe Ser Thr
                  85                  90                  95    
 Leu Arg Phe Phe Glu Gly Phe Cys Leu Ala Gly Ile Ile Leu Thr Leu
             100                 105                 110        
 Tyr Ala Leu Gln Ser Glu Ala Thr Asp His Ser Leu Pro Pro Met Ser
         115                 120                 125            
 Leu Thr Gly Glu Asp Asp Asp Leu Cys Phe Arg Pro Gly Lys Ile Gly
     130                 135                 140                
 Gln Val Ala Asp Gln Met Asn Val Ile Val Ile Cys Lys Thr Met Lys
 145                 150                 155                 160
 Phe Gln Gly Ser Val Gly Gly His Leu His Val Cys Asp Val Met Ala
                 165                 170                 175    
 Thr Ile Leu Leu Gln Ala Pro Glu Leu Pro
             180                 185    



      <210> 1353
      <211> 634
      <212> PRT
      <213> Homo sapiens


      <400> 1353
 Met Ala Gly Cys Phe Arg Gly Val Lys Gly Gly Ala Gly Gln Trp Ser
   1               5                  10                  15    
 Phe Pro Met Thr Asp Ile Asn Gln Thr Val Arg Ser Trp Gly Val Ala
              20                  25                  30        
 Ser Pro Glu Phe Gly Val Phe Ser Pro His Asn Val Thr Val Arg Thr
          35                  40                  45            
 Ala Glu Gly Lys Glu Gly Gly Arg Lys Ala Lys Leu Gly Leu Arg His
      50                  55                  60                
 Val Val Gly Lys Leu Ala Gly Pro Arg Ser Arg Leu Pro Ala Leu Pro
  65                  70                  75                  80
 Ala Ala Leu Ala Ala Pro Ser Arg Ala Ala Asn Gly Cys Pro Gln Leu
                  85                  90                  95    
 Cys Arg Cys Glu Gly Arg Leu Leu Tyr Cys Glu Ala Leu Asn Leu Thr
             100                 105                 110        
 Glu Ala Pro His Asn Leu Ser Gly Leu Leu Gly Leu Ser Leu Arg Tyr
         115                 120                 125            
 Asn Ser Leu Ser Glu Leu Arg Ala Gly Gln Phe Thr Gly Leu Met Gln
     130                 135                 140                
 Leu Thr Trp Leu Tyr Leu Asp His Asn His Ile Cys Ser Val Gln Gly
 145                 150                 155                 160
 Asp Ala Phe Gln Lys Leu Arg Arg Val Lys Glu Leu Thr Leu Ser Ser
                 165                 170                 175    
 Asn Gln Ile Thr Gln Leu Pro Asn Thr Thr Phe Arg Pro Met Pro Asn
             180                 185                 190        
 Leu Arg Ser Val Asp Leu Ser Tyr Asn Lys Leu Gln Ala Leu Ala Pro
         195                 200                 205            
 Asp Leu Phe His Gly Leu Arg Lys Leu Thr Thr Leu His Met Arg Ala
     210                 215                 220                
 Asn Ala Ile Gln Phe Val Pro Val Arg Ile Phe Gln Asp Cys Arg Ser
 225                 230                 235                 240
 Leu Lys Phe Leu Asp Ile Gly Tyr Asn Gln Leu Lys Ser Leu Ala Arg
                 245                 250                 255    
 Asn Ser Phe Ala Gly Leu Phe Lys Leu Thr Glu Leu His Leu Glu His
             260                 265                 270        
 Asn Asp Leu Val Lys Val Asn Phe Ala His Phe Pro Arg Leu Ile Ser
         275                 280                 285            
 Leu His Ser Leu Cys Leu Arg Arg Asn Lys Val Ala Ile Val Val Ser
     290                 295                 300                
 Ser Leu Asp Trp Val Trp Asn Leu Glu Lys Met Asp Leu Ser Gly Asn
 305                 310                 315                 320
 Glu Ile Glu Tyr Met Glu Pro His Val Phe Glu Thr Val Pro His Leu
                 325                 330                 335    
 Gln Ser Leu Gln Leu Asp Ser Asn Arg Leu Thr Tyr Ile Glu Pro Arg
             340                 345                 350        
 Ile Leu Asn Ser Trp Lys Ser Leu Thr Ser Ile Thr Leu Ala Gly Asn
         355                 360                 365            
 Leu Trp Asp Cys Gly Arg Asn Val Cys Ala Leu Ala Ser Trp Leu Asn
     370                 375                 380                
 Asn Phe Gln Gly Arg Tyr Asp Gly Asn Leu Gln Cys Ala Ser Pro Glu
 385                 390                 395                 400
 Tyr Ala Gln Gly Glu Asp Val Leu Asp Ala Val Tyr Ala Phe His Leu
                 405                 410                 415    
 Cys Glu Asp Gly Ala Glu Pro Thr Ser Gly His Leu Leu Ser Ala Val
             420                 425                 430        
 Thr Asn Arg Ser Asp Leu Gly Pro Pro Ala Ser Ser Ala Thr Thr Leu
         435                 440                 445            
 Ala Asp Gly Gly Glu Gly Gln His Asp Gly Thr Phe Glu Pro Ala Thr
     450                 455                 460                
 Val Ala Leu Pro Gly Gly Glu His Ala Glu Asn Ala Val Gln Ile His
 465                 470                 475                 480
 Lys Val Val Thr Gly Thr Met Ala Leu Ile Phe Ser Phe Leu Ile Val
                 485                 490                 495    
 Val Leu Val Leu Tyr Val Ser Trp Lys Cys Phe Pro Ala Ser Leu Arg
             500                 505                 510        
 Gln Leu Arg Gln Cys Phe Val Thr Gln Arg Arg Lys Gln Lys Gln Lys
         515                 520                 525            
 Gln Thr Met His Gln Met Ala Ala Met Ser Ala Gln Glu Tyr Tyr Val
     530                 535                 540                
 Asp Tyr Lys Pro Asn His Ile Glu Gly Ala Leu Val Ile Ile Asn Glu
 545                 550                 555                 560
 Tyr Gly Ser Cys Thr Cys His Gln Gln Pro Ala Arg Glu Cys Glu Val
                 565                 570                 575    
 Ser Arg Ser Ile Ile Glu Ile Ser Val Ser Ile Glu Leu Lys Ser Glu
             580                 585                 590        
 Glu Val Val Val Val Ala Val Gly Gly Cys Arg Glu Gly Lys Gly Lys
         595                 600                 605            
 Ala Val Cys Ile Gly Arg Arg Ala Pro Ser Ser Asp Asp Asn Leu Ser
     610                 615                 620                
 Lys Cys Met Ile Glu Ile Asn Cys His Gly
 625                 630                



      <210> 1354
      <211> 253
      <212> PRT
      <213> Homo sapiens


      <400> 1354
 Met Ala Ala Trp Gly Phe Cys Phe Ala Val Ser Ala Leu Val Val Ala
   1               5                  10                  15    
 Cys Glu Phe Thr Arg Leu His Gly Cys Leu Arg Leu Ser Trp Gly Asn
              20                  25                  30        
 Phe Thr Ala Ala Phe Ala Met Leu Ala Thr Leu Leu Cys Ala Thr Ala
          35                  40                  45            
 Ala Val Leu Tyr Pro Leu Tyr Phe Ala Arg Arg Glu Cys Pro Pro Glu
      50                  55                  60                
 Pro Ala Gly Cys Ala Ala Arg Asp Phe Arg Leu Ala Ala Ser Val Phe
  65                  70                  75                  80
 Ala Gly Leu Leu Phe Leu Ala Tyr Ala Val Glu Val Ala Leu Thr Arg
                  85                  90                  95    
 Ala Arg Pro Gly Gln Val Ser Ser Tyr Met Ala Thr Val Ser Gly Leu
             100                 105                 110        
 Leu Lys Ile Val Gln Ala Phe Val Ala Cys Ile Ile Phe Gly Ala Leu
         115                 120                 125            
 Val His Asp Ser Arg Tyr Gly Arg Tyr Val Ala Thr Gln Trp Cys Val
     130                 135                 140                
 Ala Val Tyr Ser Leu Cys Phe Leu Ala Thr Val Ala Val Val Ala Leu
 145                 150                 155                 160
 Ser Val Met Gly His Thr Gly Gly Leu Gly Cys Pro Phe Asp Arg Leu
                 165                 170                 175    
 Val Val Val Tyr Thr Phe Leu Ala Val Leu Leu Tyr Leu Ser Ala Ala
             180                 185                 190        
 Val Ile Trp Pro Val Phe Cys Phe Asp Pro Lys Tyr Gly Glu Pro Lys
         195                 200                 205            
 Arg Pro Pro Asn Cys Ala Arg Gly Ser Cys Pro Trp Asp Ser Gln Leu
     210                 215                 220                
 Val Val Ala Ile Phe Thr Tyr Val Asn Leu Leu Leu Tyr Val Val Asp
 225                 230                 235                 240
 Leu Ala Tyr Ser Gln Arg Ile Arg Phe Val Pro Ser Leu
                 245                 250            



      <210> 1355
      <211> 133
      <212> PRT
      <213> Homo sapiens


      <400> 1355
 Met Gly Arg Val Ser Gly Leu Val Pro Ser Arg Phe Leu Thr Leu Leu
   1               5                  10                  15    
 Ala His Leu Val Val Val Ile Thr Leu Phe Trp Ser Arg Asp Ser Asn
              20                  25                  30        
 Ile Gln Ala Cys Leu Pro Leu Thr Phe Thr Pro Glu Glu Tyr Asp Lys
          35                  40                  45            
 Gln Asp Ile Gln Leu Val Ala Ala Leu Ser Val Thr Leu Gly Leu Phe
      50                  55                  60                
 Ala Val Glu Leu Ala Gly Phe Leu Ser Gly Val Ser Met Phe Asn Ser
  65                  70                  75                  80
 Thr Gln Ser Leu Ile Ser Ile Gly Ala His Cys Ser Ala Ser Val Ala
                  85                  90                  95    
 Leu Ser Phe Phe Ile Phe Glu Arg Trp Glu Cys Thr Thr Tyr Trp Tyr
             100                 105                 110        
 Ile Phe Val Phe Cys Arg Cys Gly Ser Ile Gln Tyr Leu Gly Met Arg
         115                 120                 125            
 Glu Glu Gly Trp Pro
     130            



      <210> 1356
      <211> 395
      <212> PRT
      <213> Homo sapiens


      <400> 1356
 Met Gly Arg Ala Arg Arg Phe Gln Trp Pro Leu Leu Leu Leu Trp Ala
   1               5                  10                  15    
 Ala Ala Ala Gly Pro Gly Ala Gly Gln Glu Val Gln Thr Glu Asn Val
              20                  25                  30        
 Thr Val Ala Glu Gly Gly Val Ala Glu Ile Thr Cys Arg Leu His Gln
          35                  40                  45            
 Tyr Asp Gly Ser Ile Val Val Ile Gln Asn Pro Ala Arg Gln Thr Leu
      50                  55                  60                
 Phe Phe Asn Gly Thr Arg Ala Leu Lys Asp Glu Arg Phe Gln Leu Glu
  65                  70                  75                  80
 Glu Phe Ser Pro Arg Arg Val Arg Ile Arg Leu Ser Asp Ala Arg Leu
                  85                  90                  95    
 Glu Asp Glu Gly Gly Tyr Phe Cys Gln Leu Tyr Thr Glu Asp Thr His
             100                 105                 110        
 His Gln Ile Ala Thr Leu Thr Val Leu Val Ala Pro Glu Asn Pro Val
         115                 120                 125            
 Val Glu Val Arg Glu Gln Ala Val Glu Gly Gly Glu Val Glu Leu Ser
     130                 135                 140                
 Cys Leu Val Pro Arg Ser Arg Pro Ala Ala Thr Leu Arg Trp Tyr Arg
 145                 150                 155                 160
 Asp Arg Lys Glu Leu Lys Val Ser Asp Arg Gly Val Ala Gly Val Ser
                 165                 170                 175    
 Ser Ser Gln Glu Asn Gly Lys Val Trp Ser Val Ala Ser Thr Val Arg
             180                 185                 190        
 Phe Arg Val Asp Arg Lys Asp Asp Gly Gly Ile Ile Ile Cys Glu Ala
         195                 200                 205            
 Gln Asn Gln Ala Leu Pro Ser Gly His Ser Lys Gln Thr Gln Tyr Val
     210                 215                 220                
 Leu Asp Val Gln Tyr Ser Pro Thr Ala Arg Ile His Ala Ser Gln Ala
 225                 230                 235                 240
 Val Val Arg Glu Gly Asp Thr Leu Val Leu Thr Cys Ala Val Thr Gly
                 245                 250                 255    
 Asn Pro Arg Pro Asn Gln Ile Arg Trp Asn Arg Gly Asn Glu Ser Leu
             260                 265                 270        
 Pro Glu Arg Ala Glu Ala Val Gly Glu Thr Leu Thr Leu Pro Gly Leu
         275                 280                 285            
 Val Ser Ala Asp Asn Gly Thr Tyr Thr Cys Glu Ala Ser Asn Lys His
     290                 295                 300                
 Gly His Ala Arg Ala Leu Tyr Val Leu Val Val Tyr Asp Pro Gly Ala
 305                 310                 315                 320
 Val Val Glu Ala Gln Thr Ser Val Pro Tyr Ala Ile Val Gly Gly Ile
                 325                 330                 335    
 Leu Ala Leu Leu Val Phe Leu Ile Ile Cys Val Leu Val Gly Met Val
             340                 345                 350        
 Trp Cys Ser Val Arg Gln Lys Gly Ser Tyr Leu Thr His Glu Ala Ser
         355                 360                 365            
 Gly Leu Asp Glu Gln Gly Glu Val Arg Glu Ala Phe Leu Asn Gly Ser
     370                 375                 380                
 Asp Gly His Lys Arg Lys Glu Glu Phe Phe Ile
 385                 390                 395



      <210> 1357
      <211> 481
      <212> PRT
      <213> Homo sapiens


      <400> 1357
 Met Gly Cys Ser Ala Lys Ala Arg Trp Ala Ala Gly Ala Leu Gly Val
   1               5                  10                  15    
 Ala Gly Leu Leu Cys Ala Val Leu Gly Ala Val Met Ile Val Met Val
              20                  25                  30        
 Pro Ser Leu Ile Lys Gln Gln Val Leu Lys Asn Val Arg Ile Asp Pro
          35                  40                  45            
 Ser Ser Leu Ser Phe Asn Met Trp Lys Glu Ile Pro Ile Pro Phe Tyr
      50                  55                  60                
 Leu Ser Val Tyr Phe Phe Asp Val Met Asn Pro Ser Glu Ile Leu Lys
  65                  70                  75                  80
 Gly Glu Lys Pro Gln Val Arg Glu Arg Gly Pro Tyr Val Tyr Arg Glu
                  85                  90                  95    
 Ser Arg His Lys Ser Asn Ile Thr Phe Asn Asn Asn Asp Thr Val Ser
             100                 105                 110        
 Phe Leu Glu Tyr Arg Thr Phe Gln Phe Gln Pro Ser Lys Ser His Gly
         115                 120                 125            
 Ser Glu Ser Asp Tyr Ile Val Met Pro Asn Ile Leu Val Leu Gly Ala
     130                 135                 140                
 Ala Val Met Met Glu Asn Lys Pro Met Thr Leu Lys Leu Ile Met Thr
 145                 150                 155                 160
 Leu Ala Phe Thr Thr Leu Gly Glu Arg Ala Phe Met Asn Arg Thr Val
                 165                 170                 175    
 Gly Glu Ile Met Trp Gly Tyr Lys Asp Pro Leu Val Asn Leu Ile Asn
             180                 185                 190        
 Lys Tyr Phe Pro Gly Met Phe Pro Phe Lys Asp Lys Phe Gly Leu Phe
         195                 200                 205            
 Ala Glu Leu Asn Asn Ser Asp Ser Gly Leu Phe Thr Val Phe Thr Gly
     210                 215                 220                
 Val Gln Asn Ile Ser Arg Ile His Leu Val Asp Lys Trp Asn Gly Leu
 225                 230                 235                 240
 Ser Lys Val Asp Phe Trp His Ser Asp Gln Cys Asn Met Ile Asn Gly
                 245                 250                 255    
 Thr Ser Gly Gln Met Trp Pro Pro Phe Met Thr Pro Glu Ser Ser Leu
             260                 265                 270        
 Glu Phe Tyr Ser Pro Glu Ala Cys Arg Ser Met Lys Leu Met Tyr Lys
         275                 280                 285            
 Glu Ser Gly Val Phe Glu Gly Ile Pro Thr Tyr Arg Phe Val Ala Pro
     290                 295                 300                
 Lys Thr Leu Phe Ala Asn Gly Ser Ile Tyr Pro Pro Asn Glu Gly Phe
 305                 310                 315                 320
 Cys Pro Cys Leu Glu Ser Gly Ile Gln Asn Val Ser Thr Cys Arg Phe
                 325                 330                 335    
 Ser Ala Pro Leu Phe Leu Ser His Pro His Phe Leu Asn Ala Asp Pro
             340                 345                 350        
 Val Leu Ala Glu Ala Val Thr Gly Leu His Pro Asn Gln Glu Ala His
         355                 360                 365            
 Ser Leu Phe Leu Asp Ile His Pro Val Thr Gly Ile Pro Met Asn Cys
     370                 375                 380                
 Ser Val Lys Leu Gln Leu Ser Leu Tyr Met Lys Ser Val Ala Gly Ile
 385                 390                 395                 400
 Gly Gln Thr Gly Lys Ile Glu Pro Val Val Leu Pro Leu Leu Trp Phe
                 405                 410                 415    
 Ala Glu Ser Gly Ala Met Glu Gly Glu Thr Leu His Thr Phe Tyr Thr
             420                 425                 430        
 Gln Leu Val Leu Met Pro Lys Glu Lys Cys Tyr Leu Phe Trp Ser Ser
         435                 440                 445            
 Ser Lys Lys Gly Ser Lys Asp Lys Glu Ala Ile Gln Ala Tyr Ser Glu
     450                 455                 460                
 Ser Leu Met Thr Ser Ala Pro Lys Gly Ser Val Leu Gln Glu Ala Lys
 465                 470                 475                 480
 Leu
    



      <210> 1358
      <211> 375
      <212> PRT
      <213> Homo sapiens


      <400> 1358
 Met Lys Arg Gln Ser Pro Glu Glu Phe Trp Gly Ser Glu Ala Gln Leu
   1               5                  10                  15    
 Tyr Asp Ala Asp Val Val Ser Thr Leu Val Lys Thr His Arg Met Tyr
              20                  25                  30        
 Thr Lys Ser Glu Pro Arg Arg Gly Leu Pro Asp Pro Gly His Leu Ala
          35                  40                  45            
 Met Asp Thr Ala Ser Cys Pro Val Ala Ser Leu Ser Met Leu His Ser
      50                  55                  60                
 Tyr Met Ala Pro Leu Arg Phe Pro Arg Arg Pro Ser Val Leu Lys Leu
  65                  70                  75                  80
 Cys Leu Ala Lys Asn Pro Gln Glu Glu Arg Arg Asp Asp Cys Val Val
                  85                  90                  95    
 His Pro Glu Ser Gln Ala Gln Val Arg Leu Gly Gly Pro Glu Arg Ser
             100                 105                 110        
 Ala Gly Ile Ala Pro Gln Gly Ser His Val Glu Asp Thr Gly Ala Ala
         115                 120                 125            
 Gly Val Arg Trp Phe Ser Leu Arg Thr Arg Ser Trp Ser Trp Ala His
     130                 135                 140                
 Pro Gly Lys Asp Ala Ile Asp Glu Ser Ser Leu Val Pro Arg Leu Ala
 145                 150                 155                 160
 Leu Leu Trp Glu Leu Gln Leu Arg Gly Leu Cys Leu Gly Thr Gly Leu
                 165                 170                 175    
 Trp Gly Val Val Cys Leu Ser Ala Phe Leu Pro Val His Leu Leu Val
             180                 185                 190        
 Cys Leu Pro Val Cys Leu Pro Ala Cys Leu Ser Ile Cys Leu Ser Thr
         195                 200                 205            
 Cys Leu Ser Val Cys Leu Leu Ala Cys Leu Pro Cys Leu Ser Val Cys
     210                 215                 220                
 Leu Ser Val His Leu Ser Val Cys Leu Pro Ile Tyr Leu Ser Ala Phe
 225                 230                 235                 240
 Leu Pro Val Cys Pro Ala Cys Leu Ser Ala Cys Leu Pro Ala Cys Leu
                 245                 250                 255    
 Ser Ile Cys Leu Ser Thr Cys Leu Ser Ser Phe Leu Leu Val Cys Pro
             260                 265                 270        
 Ala Cys Leu Ser Ala Cys Leu Ser Ile His Leu Ser Ile Tyr Leu Ser
         275                 280                 285            
 Val Cys Leu Pro Ala Cys Leu Pro Val Cys Leu Ser Ala Cys Leu Ser
     290                 295                 300                
 Ala Cys Leu Ser Val Phe Leu Ser Val Arg Leu Pro Val Cys Leu Pro
 305                 310                 315                 320
 Ala Cys Leu Ser Ser Cys Leu Phe Ala Cys Leu Ser Ser Cys Leu Ser
                 325                 330                 335    
 Ala Cys Leu Cys Val Cys Leu Ser Val Cys Met Cys Ala Gln Thr Arg
             340                 345                 350        
 Leu Ile Gln Phe Leu Val Ser Leu Glu Met Gln Arg Leu Leu Gln Lys
         355                 360                 365            
 Val His Leu Met Ala Leu Ala
     370                 375



      <210> 1359
      <211> 454
      <212> PRT
      <213> Homo sapiens


      <400> 1359
 Met Thr Trp Arg Ala Ala Ala Ser Thr Cys Ala Ala Leu Leu Ile Leu
   1               5                  10                  15    
 Leu Trp Ala Leu Thr Thr Glu Gly Asp Leu Lys Val Glu Met Met Ala
              20                  25                  30        
 Gly Gly Thr Gln Ile Thr Pro Leu Asn Asp Asn Val Thr Ile Phe Cys
          35                  40                  45            
 Asn Ile Phe Tyr Ser Gln Pro Leu Asn Ile Thr Ser Met Gly Ile Thr
      50                  55                  60                
 Trp Phe Trp Lys Ser Leu Thr Phe Asp Lys Glu Val Lys Val Phe Glu
  65                  70                  75                  80
 Phe Phe Gly Asp His Gln Glu Ala Phe Arg Pro Gly Ala Ile Val Ser
                  85                  90                  95    
 Pro Trp Arg Leu Lys Ser Gly Asp Ala Ser Leu Arg Leu Pro Gly Ile
             100                 105                 110        
 Gln Leu Glu Glu Ala Gly Glu Tyr Arg Cys Glu Val Val Val Thr Pro
         115                 120                 125            
 Leu Lys Ala Gln Gly Thr Val Gln Leu Glu Val Val Ala Ser Pro Ala
     130                 135                 140                
 Ser Arg Leu Leu Leu Asp Gln Val Gly Met Lys Glu Asn Glu Asp Lys
 145                 150                 155                 160
 Tyr Met Cys Glu Ser Ser Gly Phe Tyr Pro Glu Ala Ile Asn Ile Thr
                 165                 170                 175    
 Trp Glu Lys Gln Thr Gln Lys Phe Pro His Pro Ile Glu Ile Ser Glu
             180                 185                 190        
 Asp Val Ile Thr Gly Pro Thr Ile Lys Asn Met Asp Gly Thr Phe Asn
         195                 200                 205            
 Val Thr Ser Cys Leu Lys Leu Asn Ser Ser Gln Glu Asp Pro Gly Thr
     210                 215                 220                
 Val Tyr Gln Cys Val Val Arg His Ala Ser Leu His Thr Pro Leu Arg
 225                 230                 235                 240
 Ser Asn Phe Thr Leu Thr Ala Ala Arg His Ser Leu Ser Glu Thr Glu
                 245                 250                 255    
 Lys Thr Asp Asn Phe Ser Ile His Trp Trp Pro Ile Ser Phe Ile Gly
             260                 265                 270        
 Val Gly Leu Val Leu Leu Ile Val Leu Ile Pro Trp Lys Lys Ile Cys
         275                 280                 285            
 Asn Lys Ser Ser Ser Ala Tyr Thr Pro Leu Lys Cys Ile Leu Lys His
     290                 295                 300                
 Trp Asn Ser Phe Asp Thr Gln Thr Leu Lys Lys Glu His Leu Ile Phe
 305                 310                 315                 320
 Phe Cys Thr Arg Ala Trp Pro Ser Tyr Gln Leu Gln Asp Gly Glu Ala
                 325                 330                 335    
 Trp Pro Pro Glu Gly Ser Val Asn Ile Asn Thr Ile Gln Gln Leu Asp
             340                 345                 350        
 Val Phe Cys Arg Gln Glu Gly Lys Trp Ser Glu Val Pro Tyr Val Gln
         355                 360                 365            
 Ala Phe Phe Ala Leu Arg Asp Asn Pro Asp Leu Cys Gln Cys Cys Arg
     370                 375                 380                
 Ile Asp Pro Ala Leu Leu Thr Val Thr Ser Gly Lys Ser Ile Asp Asp
 385                 390                 395                 400
 Asn Ser Thr Lys Ser Glu Lys Gln Thr Pro Arg Glu His Ser Asp Ala
                 405                 410                 415    
 Val Pro Asp Ala Pro Ile Leu Pro Val Ser Pro Ile Trp Glu Pro Pro
             420                 425                 430        
 Pro Ala Thr Thr Ser Thr Thr Pro Val Leu Ser Ser Gln Pro Pro Thr
         435                 440                 445            
 Leu Leu Leu Pro Leu Gln
     450                



      <210> 1360
      <211> 505
      <212> PRT
      <213> Homo sapiens


      <400> 1360
 Met Ser Pro Cys Glu Lys Tyr Arg Ala Arg Arg Gln Ile Pro Trp Lys
   1               5                  10                  15    
 Leu Gly Leu Gln Ile Leu Lys Ile Val Met Val Thr Thr Gln Leu Val
              20                  25                  30        
 Arg Phe Gly Leu Ser Asn Gln Leu Val Val Ala Phe Lys Glu Asp Asn
          35                  40                  45            
 Thr Val Ala Phe Lys His Leu Phe Leu Lys Gly Tyr Ser Gly Thr Asp
      50                  55                  60                
 Glu Asp Asp Tyr Ser Cys Ser Val Tyr Thr Gln Glu Asp Ala Tyr Glu
  65                  70                  75                  80
 Ser Ile Phe Phe Ala Ile Asn Gln Tyr His Gln Leu Lys Asp Ile Thr
                  85                  90                  95    
 Leu Gly Thr Leu Gly Tyr Gly Glu Asn Glu Asp Asn Arg Ile Gly Leu
             100                 105                 110        
 Lys Val Cys Lys Gln His Tyr Lys Lys Gly Thr Met Phe Pro Ser Asn
         115                 120                 125            
 Glu Thr Leu Asn Ile Asp Asn Asp Val Glu Leu Asp Cys Val Gln Leu
     130                 135                 140                
 Asp Leu Gln Asp Leu Ser Lys Lys Pro Pro Asp Trp Lys Asn Ser Ser
 145                 150                 155                 160
 Phe Phe Arg Leu Glu Phe Tyr Arg Tyr Ala Glu Ile Arg Gly Ile Phe
                 165                 170                 175    
 Ser Lys Ser Lys Tyr Arg Leu Pro Ile Phe Cys Glu Lys Lys Leu Thr
             180                 185                 190        
 Phe Val Lys Tyr Val Ile Trp Asn Ile Ile Ile Lys Ile Lys Met Met
         195                 200                 205            
 Glu Ile Ser Lys Leu Val Ser Gln Met His Phe Gln Asn Thr Gln Lys
     210                 215                 220                
 Asn Ala Gln Tyr Val Leu Val Phe Asp Ala Phe Val Ile Val Ile Cys
 225                 230                 235                 240
 Leu Ala Ser Leu Ile Leu Cys Thr Arg Ser Ile Val Leu Ala Leu Arg
                 245                 250                 255    
 Leu Arg Lys Arg Phe Leu Asn Phe Phe Leu Glu Lys Tyr Lys Arg Pro
             260                 265                 270        
 Val Cys Asp Thr Asp Gln Trp Glu Phe Ile Asn Gly Trp Tyr Val Leu
         275                 280                 285            
 Val Ile Ile Ser Asp Leu Met Thr Ile Ile Gly Ser Ile Leu Lys Met
     290                 295                 300                
 Glu Ile Lys Ala Lys Asn Leu Thr Asn Tyr Asp Leu Cys Ser Ile Phe
 305                 310                 315                 320
 Leu Gly Thr Ser Thr Leu Leu Val Trp Val Gly Val Ile Arg Tyr Leu
                 325                 330                 335    
 Gly Tyr Phe Gln Ala Tyr Asn Val Leu Ile Leu Thr Met Gln Ala Ser
             340                 345                 350        
 Leu Pro Lys Val Leu Arg Phe Cys Ala Cys Ala Gly Met Ile Tyr Leu
         355                 360                 365            
 Gly Tyr Thr Phe Cys Gly Trp Ile Val Leu Gly Pro Tyr His Asp Lys
     370                 375                 380                
 Phe Glu Asn Leu Asn Thr Val Ala Glu Cys Leu Phe Ser Leu Val Asn
 385                 390                 395                 400
 Gly Asp Asp Met Phe Ala Thr Phe Ala Gln Ile Gln Gln Lys Ser Ile
                 405                 410                 415    
 Leu Val Trp Leu Phe Ser Arg Leu Tyr Leu Tyr Ser Phe Ile Ser Leu
             420                 425                 430        
 Phe Ile Tyr Met Ile Leu Ser Leu Phe Ile Ala Leu Ile Thr Asp Ser
         435                 440                 445            
 Tyr Asp Thr Ile Lys Lys Phe Gln Gln Asn Gly Phe Pro Glu Thr Asp
     450                 455                 460                
 Leu Gln Glu Phe Leu Lys Glu Cys Ser Ser Lys Glu Glu Tyr Gln Lys
 465                 470                 475                 480
 Glu Ser Ser Ala Phe Leu Ser Cys Ile Cys Cys Arg Arg Arg Lys Arg
                 485                 490                 495    
 Ser Asp Asp His Leu Ile Pro Ile Ser
             500                 505



      <210> 1361
      <211> 103
      <212> PRT
      <213> Homo sapiens


      <400> 1361
 Met Leu Leu Leu Leu Leu Ser Val Cys Leu Phe Val Cys Phe Leu Ile
   1               5                  10                  15    
 Val Ser Ser Leu Phe Ser Arg Ala Ala Val Val Cys Trp Glu Phe Thr
              20                  25                  30        
 Ser Gly Pro Ile His Gln Val His Ser Arg Ala Trp Arg Cys His Ser
          35                  40                  45            
 Arg Arg Leu Glu Asn Ser Lys Asp Gly Cys Leu Leu Leu Pro Leu Gly
      50                  55                  60                
 Ser Leu Thr Ser Arg Gly Thr Asn Leu Met Leu Val Gly Leu Phe Leu
  65                  70                  75                  80
 Tyr Trp Val Ser Asp Asn Pro Cys Trp Arg Val Ser Pro Ser Trp Val
                  85                  90                  95    
 Ala Trp Gly Ala Gly Pro Ile
             100            



      <210> 1362
      <211> 80
      <212> PRT
      <213> Homo sapiens


      <400> 1362
 Met Asn Ser Phe Ser Val Ile Ala Ser Ile Val Val Leu Leu Pro Phe
   1               5                  10                  15    
 Pro Gly Leu Ser Val Ser Ala Cys Leu Pro Ser His Ser His Gln Cys
              20                  25                  30        
 Lys Thr Phe Ile Leu Leu Phe Leu Pro Ser Ser Glu Lys Thr Leu Ser
          35                  40                  45            
 Arg Leu Pro Pro Ser His Ser Ser Thr Tyr Thr Leu Ile Ser Leu Leu
      50                  55                  60                
 Pro Phe Ile Asn Arg Ile Ala Gly Arg Ile Val Cys Val Ser Phe Leu
  65                  70                  75                  80





      <210> 1363
      <211> 1012
      <212> PRT
      <213> Homo sapiens


      <400> 1363
 Met Glu Pro Gln Leu Ala Glu Met Ile Lys Gln Phe Gln Ser Thr Val
   1               5                  10                  15    
 Glu Thr Trp Asp Gln Cys Glu Lys Lys Ile Lys Glu Leu Lys Ser Arg
              20                  25                  30        
 Leu Gln Val Leu Lys Ala Gln Ser Glu Asp Pro Leu Pro Glu Leu His
          35                  40                  45            
 Glu Asp Leu His Asn Glu Lys Glu Leu Ile Lys Glu Leu Glu Gln Ser
      50                  55                  60                
 Leu Ala Ser Trp Thr Gln Asn Leu Lys Glu Leu Gln Thr Met Lys Ala
  65                  70                  75                  80
 Asp Leu Thr Arg His Val Leu Val Glu Asp Val Met Val Leu Lys Glu
                  85                  90                  95    
 Gln Ile Glu His Leu His Arg Gln Trp Glu Asp Leu Cys Leu Arg Val
             100                 105                 110        
 Ala Ile Arg Lys Gln Glu Ile Glu Asp Arg Leu Asn Thr Trp Val Val
         115                 120                 125            
 Phe Asn Glu Lys Asn Lys Glu Leu Cys Ala Trp Leu Val Gln Met Glu
     130                 135                 140                
 Asn Lys Val Leu Gln Thr Ala Asp Ile Ser Ile Glu Glu Met Ile Glu
 145                 150                 155                 160
 Lys Leu Gln Lys Asp Cys Met Glu Glu Ile Asn Leu Phe Ser Glu Asn
                 165                 170                 175    
 Lys Leu Gln Leu Lys Gln Met Gly Asp Gln Leu Ile Lys Ala Ser Asn
             180                 185                 190        
 Lys Ser Arg Ala Ala Glu Ile Asp Asp Lys Leu Asn Lys Ile Asn Asp
         195                 200                 205            
 Arg Trp Gln His Leu Phe Asp Val Ile Gly Ser Arg Val Lys Lys Leu
     210                 215                 220                
 Lys Glu Thr Phe Ala Phe Ile Gln Gln Leu Asp Lys Asn Met Ser Asn
 225                 230                 235                 240
 Leu Arg Thr Trp Leu Ala Arg Ile Glu Ser Glu Leu Ser Lys Pro Val
                 245                 250                 255    
 Val Tyr Asp Val Cys Asp Asp Gln Glu Ile Gln Lys Arg Leu Ala Glu
             260                 265                 270        
 Gln Gln Asp Leu Gln Arg Asp Ile Glu Gln His Ser Ala Gly Val Glu
         275                 280                 285            
 Ser Val Phe Asn Ile Cys Asp Val Leu Leu His Asp Ser Asp Ala Cys
     290                 295                 300                
 Ala Asn Glu Thr Glu Cys Asp Ser Ile Gln Gln Thr Thr Arg Ser Leu
 305                 310                 315                 320
 Asp Arg Arg Trp Arg Asn Ile Cys Ala Met Ser Met Glu Arg Arg Met
                 325                 330                 335    
 Lys Ile Glu Glu Thr Trp Arg Leu Trp Gln Lys Phe Leu Asp Asp Tyr
             340                 345                 350        
 Ser Arg Phe Glu Asp Trp Leu Lys Ser Ala Val Leu Arg Arg Leu Arg
         355                 360                 365            
 His Phe Thr Asn Gln Arg Glu Glu Phe Glu Gly Thr Arg Glu Ser Ile
     370                 375                 380                
 Leu Val Trp Leu Thr Glu Met Asp Leu Gln Leu Thr Asn Val Glu His
 385                 390                 395                 400
 Phe Ser Glu Ser Asp Ala Asp Asp Lys Met Arg Gln Leu Asn Gly Phe
                 405                 410                 415    
 Gln Gln Glu Ile Thr Leu Asn Thr Asn Lys Ile Asp Gln Leu Ile Val
             420                 425                 430        
 Phe Gly Glu Gln Leu Ile Gln Lys Ser Glu Pro Leu Asp Ala Val Leu
         435                 440                 445            
 Ile Glu Asp Glu Leu Glu Glu Leu His Arg Tyr Cys Gln Glu Val Phe
     450                 455                 460                
 Gly Arg Val Ser Arg Phe His Arg Arg Leu Thr Ser Cys Thr Pro Gly
 465                 470                 475                 480
 Leu Glu Asp Glu Lys Glu Ala Ser Glu Asn Glu Thr Asp Met Glu Asp
                 485                 490                 495    
 Pro Arg Glu Ile Gln Thr Asp Ser Trp Arg Lys Arg Gly Glu Ser Glu
             500                 505                 510        
 Glu Pro Ser Ser Pro Gln Ser Leu Cys His Leu Val Ala Pro Gly His
         515                 520                 525            
 Glu Arg Ser Gly Cys Glu Thr Pro Val Ser Val Asp Ser Ile Pro Leu
     530                 535                 540                
 Glu Trp Asp His Thr Gly Asp Val Gly Gly Ser Ser Ser His Glu Glu
 545                 550                 555                 560
 Asp Glu Glu Gly Pro Tyr Tyr Ser Ala Leu Ser Gly Lys Ser Ile Ser
                 565                 570                 575    
 Asp Gly His Ser Trp His Val Pro Asp Ser Pro Ser Cys Pro Glu His
             580                 585                 590        
 His Tyr Lys Gln Met Glu Gly Asp Arg Asn Val Pro Pro Val Pro Pro
         595                 600                 605            
 Ala Ser Ser Thr Pro Tyr Lys Pro Pro Tyr Gly Lys Leu Leu Leu Pro
     610                 615                 620                
 Pro Gly Thr Asp Gly Gly Lys Glu Gly Pro Arg Val Leu Asn Gly Asn
 625                 630                 635                 640
 Pro Gln Gln Glu Asp Gly Gly Leu Ala Gly Ile Thr Glu Gln Gln Ser
                 645                 650                 655    
 Gly Ala Phe Asp Arg Trp Glu Met Ile Gln Ala Gln Glu Leu His Asn
             660                 665                 670        
 Lys Leu Lys Ile Lys Gln Asn Leu Gln Gln Leu Asn Ser Asp Ile Ser
         675                 680                 685            
 Ala Ile Thr Thr Trp Leu Lys Lys Thr Glu Ala Glu Leu Glu Met Leu
     690                 695                 700                
 Lys Met Ala Lys Pro Pro Ser Asp Ile Gln Glu Ile Glu Leu Arg Val
 705                 710                 715                 720
 Lys Arg Leu Gln Glu Ile Leu Lys Ala Phe Asp Thr Tyr Lys Ala Leu
                 725                 730                 735    
 Val Val Ser Val Asn Val Ser Ser Lys Glu Phe Leu Gln Thr Glu Ser
             740                 745                 750        
 Pro Glu Ser Thr Glu Leu Gln Ser Arg Leu Arg Gln Leu Ser Leu Leu
         755                 760                 765            
 Trp Glu Ala Ala Gln Gly Ala Val Asp Ser Trp Arg Gly Gly Leu Arg
     770                 775                 780                
 Gln Ser Leu Met Gln Cys Gln Asp Phe His Gln Leu Ser Gln Asn Leu
 785                 790                 795                 800
 Leu Leu Trp Leu Ala Ser Ala Lys Asn Arg Arg Gln Lys Ala His Val
                 805                 810                 815    
 Thr Asp Pro Lys Ala Asp Pro Arg Ala Leu Leu Glu Cys Arg Arg Glu
             820                 825                 830        
 Leu Met Gln Leu Glu Lys Glu Leu Val Glu Arg Gln Pro Gln Val Asp
         835                 840                 845            
 Met Leu Gln Glu Ile Ser Asn Ser Leu Leu Ile Lys Gly His Gly Glu
     850                 855                 860                
 Asp Cys Ile Glu Ala Glu Glu Lys Val His Val Ile Glu Lys Lys Leu
 865                 870                 875                 880
 Lys Gln Leu Arg Glu Gln Val Ser Gln Asp Leu Met Ala Leu Gln Gly
                 885                 890                 895    
 Thr Gln Asn Pro Ala Ser Pro Leu Pro Ser Phe Asp Glu Val Asp Ser
             900                 905                 910        
 Gly Asp Gln Pro Pro Ala Thr Ser Val Pro Ala Pro Arg Ala Lys Gln
         915                 920                 925            
 Phe Arg Ala Val Arg Thr Thr Glu Gly Glu Glu Glu Thr Glu Ser Arg
     930                 935                 940                
 Val Pro Gly Ser Thr Arg Pro Gln Arg Ser Phe Leu Ser Arg Val Val
 945                 950                 955                 960
 Arg Ala Ala Leu Pro Leu Gln Leu Leu Leu Leu Leu Leu Leu Leu Leu
                 965                 970                 975    
 Ala Cys Leu Leu Pro Ser Ser Glu Glu Asp Tyr Ser Cys Thr Gln Ala
             980                 985                 990        
 Asn Asn Phe Ala Arg Ser Phe Tyr Pro Met Leu Arg Tyr Thr Asn Gly
         995                1000                1005            
 Pro Pro Pro Thr
    1010        



      <210> 1364
      <211> 109
      <212> PRT
      <213> Homo sapiens


      <400> 1364
 Met Ser Glu Arg His Gly Pro Ser Pro Gln Ser Val Leu Leu Ser Leu
   1               5                  10                  15    
 Trp Phe Val Leu Thr Leu Thr Pro Phe Leu Phe Leu Thr Leu Leu Ser
              20                  25                  30        
 Cys Met Glu His Thr Ala Pro Ala Pro Phe Gln Ser Ala Trp Gln Thr
          35                  40                  45            
 Pro Gly Leu Cys Arg Ser Ser Ser Phe Cys Val Pro Phe Arg Ser Ser
      50                  55                  60                
 Leu Cys Cys Arg Gln Val Ile Glu Gly Glu Gly Arg Pro Trp Gln Pro
  65                  70                  75                  80
 Ser Gly Lys Ser Leu Asp Ser Trp Pro Ser Val Ala Gly Leu Gln Pro
                  85                  90                  95    
 Leu Gly Gly Gly Asn Phe Tyr Leu Thr Lys Lys Trp Asn
             100                 105                



      <210> 1365
      <211> 90
      <212> PRT
      <213> Homo sapiens


      <400> 1365
 Met Met Glu Ala His Phe Lys Tyr His Gly Asn Leu Thr Gly Arg Ala
   1               5                  10                  15    
 His Phe Pro Thr Leu Ala Thr Glu Val Asp Thr Ser Ser Asp Lys Tyr
              20                  25                  30        
 Ser Asn Leu Tyr Met Tyr Val Gly Leu Phe Leu Ser Leu Leu Ala Ile
          35                  40                  45            
 Leu Leu Ile Leu Leu Phe Thr Met Leu Leu Arg Leu Lys His Val Ile
      50                  55                  60                
 Ser Pro Ile Asn Ser Asp Ser Thr Glu Ser Val Pro Gln Phe Thr Asp
  65                  70                  75                  80
 Val Glu Met Gln Ser Arg Ile Pro Thr Pro
                  85                  90



      <210> 1366
      <211> 393
      <212> PRT
      <213> Homo sapiens


      <400> 1366
 Met Ser Lys Gly Met Cys Pro Cys Ile Cys Leu Ala Val Ala Gly Leu
   1               5                  10                  15    
 Gly Val Glu Ala Glu Cys Thr Met Ile Thr Ala Lys Cys Arg His Gln
              20                  25                  30        
 Ala Phe Gly Phe Tyr Thr Ser Phe Thr Gln Arg Thr Arg Ala Ser His
          35                  40                  45            
 Phe Leu Val Glu Glu Lys Asp Pro Arg Ser Arg Ser Pro Ser Ala Gly
      50                  55                  60                
 Ala Gly Arg Pro Arg Arg Pro Thr Ile Thr Ser Pro Gly Gly Lys Glu
  65                  70                  75                  80
 Glu Leu Val Ala Val Ala Ser Arg Leu Trp Gln Arg Arg Arg Arg Ala
                  85                  90                  95    
 Cys Leu Ala Ala Val Gly Val Leu Leu Ala Met Ala Leu Gly Leu Leu
             100                 105                 110        
 Ile Ala Val Pro Leu Leu Leu Gln Ala Ala Pro Arg Gly Ala Ala His
         115                 120                 125            
 Tyr Glu Met Met Gly Thr Cys Arg Met Ile Cys Asp Pro Tyr Thr Ala
     130                 135                 140                
 Ala Pro Gly Gly Glu Pro Pro Gly Ala Lys Ala Gln Pro Pro Gly Pro
 145                 150                 155                 160
 Ser Thr Ala Ala Leu Glu Val Met Gln Asp Leu Ser Ala Asn Pro Pro
                 165                 170                 175    
 Pro Pro Phe Ile Gln Gly Pro Lys Gly Asp Pro Gly Arg Pro Gly Lys
             180                 185                 190        
 Pro Gly Pro Arg Gly Thr Thr Gly Glu Pro Gly Pro Pro Gly Pro Arg
         195                 200                 205            
 Gly Pro Pro Gly Glu Lys Gly Asp Ser Gly Arg Pro Gly Leu Pro Gly
     210                 215                 220                
 Leu Arg Leu Thr Ala Gly Ser Ala Ser Gly Val Gly Val Val Ala Arg
 225                 230                 235                 240
 Gly Ala Gly Val Gly Gly Asp Ser Glu Gly Glu Val Thr Ser Ala Leu
                 245                 250                 255    
 Ser Ala Thr Phe Ser Gly Pro Lys Ile Ala Phe Tyr Val Gly Leu Lys
             260                 265                 270        
 Ser Pro His Glu Gly Tyr Glu Val Leu Lys Phe Asp Asp Val Val Thr
         275                 280                 285            
 Asn Leu Gly Asn His Tyr Asp Pro Thr Thr Gly Lys Phe Ser Cys Gln
     290                 295                 300                
 Val Arg Gly Ile Tyr Phe Phe Thr Tyr His Ile Leu Met Arg Gly Gly
 305                 310                 315                 320
 Asp Gly Thr Ser Met Trp Ala Asp Leu Cys Lys Asn Gly Gln Val Arg
                 325                 330                 335    
 Ala Ser Ala Ile Ala Gln Asp Ala Asp Gln Asn Tyr Asp Tyr Ala Ser
             340                 345                 350        
 Asn Ser Val Val Leu His Leu Asp Ser Gly Asp Glu Val Tyr Val Lys
         355                 360                 365            
 Leu Asp Gly Gly Lys Ala His Gly Gly Asn Asn Asn Lys Tyr Ser Thr
     370                 375                 380                
 Phe Ser Gly Phe Leu Leu Tyr Pro Asp
 385                 390            



      <210> 1367
      <211> 132
      <212> PRT
      <213> Homo sapiens


      <400> 1367
 Met Val Leu Cys Phe Pro Leu Leu Leu Leu Leu Leu Val Leu Trp Gly
   1               5                  10                  15    
 Pro Val Cys Pro Leu His Ala Trp Pro Lys Arg Leu Thr Lys Ala His
              20                  25                  30        
 Trp Phe Glu Ile Gln His Ile Gln Pro Ser Pro Leu Gln Cys Asn Arg
          35                  40                  45            
 Ala Met Ser Gly Ile Asn Asn Tyr Thr Gln His Cys Lys His Gln Asn
      50                  55                  60                
 Thr Phe Leu His Asp Ser Phe Gln Asn Val Ala Ala Val Cys Asp Leu
  65                  70                  75                  80
 Leu Ser Ile Val Cys Ser Arg Leu Thr Ser Gly Lys Tyr Pro Gln Cys
                  85                  90                  95    
 Arg Tyr Ser Ala Ala Ala Gln Tyr Lys Phe Phe Ile Val Ala Cys Asp
             100                 105                 110        
 Pro Pro Gln Lys Ser Asp Pro Pro Tyr Lys Leu Val Pro Val His Leu
         115                 120                 125            
 Asp Ser Ile Leu
     130        



      <210> 1368
      <211> 145
      <212> PRT
      <213> Homo sapiens


      <400> 1368
 Met Asn His Ala Cys Leu Pro Asp Phe Thr Val Arg Ala Arg Ser Gln
   1               5                  10                  15    
 Trp Thr Arg Tyr Pro Ala Ser Pro Glu Pro Arg Ala Arg Ser Ser Ala
              20                  25                  30        
 Gly Ala Trp Ser Gln Arg Pro Arg Arg Arg Val Pro Gly Pro Thr Met
          35                  40                  45            
 Ala Ser Ser Ala Ala Gly Cys Val Val Ile Val Gly Ser Gly Val Ile
      50                  55                  60                
 Gly Arg Ser Trp Ala Met Leu Phe Ala Ser Gly Gly Phe Gln Val Lys
  65                  70                  75                  80
 Leu Tyr Asp Ile Glu Gln Gln Gln Ile Arg Asn Ala Leu Glu Asn Ile
                  85                  90                  95    
 Ile Lys Glu Met Lys Leu Leu Glu Gln Ala Gly Ser Leu Lys Gly Ser
             100                 105                 110        
 Leu Ser Val Glu Glu Gln Leu Ser Leu Ile Ser Gly Cys Pro Ile Ser
         115                 120                 125            
 Lys Lys Gln Tyr Arg Val Pro Cys Thr Phe Arg Asn Val Phe Gln Lys
     130                 135                 140                
 Ile
 145



      <210> 1369
      <211> 153
      <212> PRT
      <213> Homo sapiens


      <400> 1369
 Met Asn His Ala Cys Leu Pro Asp Phe Thr Val Arg Ala Arg Ser Gln
   1               5                  10                  15    
 Trp Thr Arg Tyr Pro Ala Ser Pro Glu Pro Arg Ala Arg Ser Ser Ala
              20                  25                  30        
 Gly Ala Trp Ser Gln Arg Pro Arg Arg Arg Val Pro Gly Pro Thr Met
          35                  40                  45            
 Ala Ser Ser Ala Ala Gly Cys Val Val Ile Val Gly Ser Gly Val Ile
      50                  55                  60                
 Gly Arg Ser Trp Ala Met Leu Phe Ala Ser Gly Gly Phe Gln Val Lys
  65                  70                  75                  80
 Leu Tyr Asp Ile Glu Gln Gln Gln Ile Arg Asn Ala Leu Glu Asn Ile
                  85                  90                  95    
 Arg Trp Ala Ser Arg Arg Ser Pro Glu Gly Met Glu Val Gly Leu Phe
             100                 105                 110        
 Leu Ser Val Gly Leu Val Cys His Ile Leu Lys Ala Met Arg Ile Cys
         115                 120                 125            
 Asp Val Thr Phe Ser Ser Asp Gly Tyr Cys Ser Ala Ser Glu Leu Val
     130                 135                 140                
 Lys Ala Arg Pro Thr Val Ala Gly Met
 145                 150            



      <210> 1370
      <211> 5
      <212> PRT
      <213> Homo sapiens


      <400> 1370
 Phe Ser Phe Ser Cys
   1               5



      <210> 1371
      <211> 825
      <212> PRT
      <213> Homo sapiens


      <400> 1371
 Met Ala Gly Cys Arg Gly Ser Leu Cys Cys Cys Cys Arg Trp Cys Cys
   1               5                  10                  15    
 Cys Cys Gly Glu Arg Glu Thr Arg Thr Pro Glu Glu Leu Thr Ile Leu
              20                  25                  30        
 Gly Glu Thr Gln Glu Glu Glu Asp Glu Ile Leu Pro Arg Lys Asp Tyr
          35                  40                  45            
 Glu Val Gly Leu Phe Val Asp Phe Phe Val Arg Leu Phe Thr Gln Leu
      50                  55                  60                
 Lys Phe Gly Val Val Gln Thr Ser Val Glu Glu Cys Ser Gln Lys Gly
  65                  70                  75                  80
 Cys Leu Ala Leu Ser Leu Leu Glu Leu Leu Gly Phe Asn Leu Thr Phe
                  85                  90                  95    
 Val Phe Leu Ala Ser Leu Leu Val Leu Ile Glu Pro Val Ala Ala Gly
             100                 105                 110        
 Ser Gly Ile Pro Glu Val Lys Cys Tyr Leu Asn Gly Val Lys Val Pro
         115                 120                 125            
 Gly Ile Val Arg Leu Arg Thr Leu Leu Cys Lys Val Leu Gly Val Leu
     130                 135                 140                
 Phe Ser Val Ala Gly Gly Leu Phe Val Gly Lys Glu Gly Pro Met Ile
 145                 150                 155                 160
 His Ser Gly Ser Val Val Gly Ala Gly Leu Pro Gln Phe Gln Ser Ile
                 165                 170                 175    
 Ser Leu Arg Lys Ile Gln Phe Asn Phe Pro Tyr Phe Arg Ser Asp Arg
             180                 185                 190        
 Asp Lys Arg Asp Phe Val Ser Ala Gly Ala Ala Ala Gly Val Ala Ala
         195                 200                 205            
 Ala Phe Gly Ala Pro Ile Gly Gly Thr Leu Phe Ser Leu Glu Glu Gly
     210                 215                 220                
 Ser Ser Phe Trp Asn Gln Gly Leu Thr Trp Lys Val Leu Phe Cys Ser
 225                 230                 235                 240
 Met Ser Ala Thr Phe Thr Leu Asn Phe Phe Arg Ser Gly Ile Gln Phe
                 245                 250                 255    
 Gly Ser Trp Gly Ser Phe Gln Leu Pro Gly Leu Leu Asn Phe Gly Glu
             260                 265                 270        
 Phe Lys Cys Ser Asp Ser Asp Lys Lys Cys His Leu Trp Thr Ala Met
         275                 280                 285            
 Asp Leu Gly Phe Phe Val Val Met Gly Val Ile Gly Gly Leu Leu Gly
     290                 295                 300                
 Ala Thr Phe Asn Cys Leu Asn Lys Arg Leu Ala Lys Tyr Arg Met Arg
 305                 310                 315                 320
 Asn Val His Pro Lys Pro Lys Leu Val Arg Val Leu Glu Ser Leu Leu
                 325                 330                 335    
 Val Ser Leu Val Thr Thr Val Val Val Phe Val Ala Ser Met Val Leu
             340                 345                 350        
 Gly Glu Cys Arg Gln Met Ser Ser Ser Ser Gln Ile Gly Asn Asp Ser
         355                 360                 365            
 Phe Gln Leu Gln Val Thr Glu Asp Val Asn Ser Ser Ile Lys Thr Phe
     370                 375                 380                
 Phe Cys Pro Asn Asp Thr Tyr Asn Asp Met Ala Thr Leu Phe Phe Asn
 385                 390                 395                 400
 Pro Gln Glu Ser Ala Ile Leu Gln Leu Phe His Gln Asp Gly Thr Phe
                 405                 410                 415    
 Ser Pro Val Thr Leu Ala Leu Phe Phe Val Leu Tyr Phe Leu Leu Ala
             420                 425                 430        
 Cys Trp Thr Tyr Gly Ile Ser Val Pro Ser Gly Leu Phe Val Pro Ser
         435                 440                 445            
 Leu Leu Cys Gly Ala Ala Phe Gly Arg Leu Val Ala Asn Val Leu Lys
     450                 455                 460                
 Ser Tyr Ile Gly Leu Gly His Ile Tyr Ser Gly Thr Phe Ala Leu Ile
 465                 470                 475                 480
 Gly Ala Ala Ala Phe Leu Gly Gly Val Val Arg Met Thr Ile Ser Leu
                 485                 490                 495    
 Thr Val Ile Leu Ile Glu Ser Thr Asn Glu Ile Thr Tyr Gly Leu Pro
             500                 505                 510        
 Ile Met Val Thr Leu Met Val Ala Lys Trp Thr Gly Asp Phe Phe Asn
         515                 520                 525            
 Lys Gly Ile Tyr Asp Ile His Val Gly Leu Arg Gly Val Pro Leu Leu
     530                 535                 540                
 Glu Trp Glu Thr Glu Val Glu Met Asp Lys Leu Arg Ala Ser Asp Ile
 545                 550                 555                 560
 Met Glu Pro Asn Leu Thr Tyr Val Tyr Pro His Thr Arg Ile Gln Ser
                 565                 570                 575    
 Leu Val Ser Ile Leu Arg Thr Thr Val His His Ala Phe Pro Val Val
             580                 585                 590        
 Thr Glu Asn Arg Gly Asn Glu Lys Glu Phe Met Lys Gly Asn Gln Leu
         595                 600                 605            
 Ile Ser Asn Asn Ile Lys Phe Lys Lys Ser Ser Ile Leu Thr Arg Ala
     610                 615                 620                
 Gly Glu Gln Arg Lys Arg Ser Gln Ser Met Lys Ser Tyr Pro Ser Ser
 625                 630                 635                 640
 Glu Leu Arg Asn Met Cys Asp Glu His Ile Ala Ser Glu Glu Pro Ala
                 645                 650                 655    
 Glu Lys Glu Asp Leu Leu Gln Gln Met Leu Glu Arg Arg Tyr Thr Pro
             660                 665                 670        
 Tyr Pro Asn Leu Tyr Pro Asp Gln Ser Pro Ser Glu Asp Trp Thr Met
         675                 680                 685            
 Glu Glu Arg Phe Arg Pro Leu Thr Phe His Gly Leu Ile Leu Arg Ser
     690                 695                 700                
 Gln Leu Val Thr Leu Leu Val Arg Gly Val Cys Tyr Ser Glu Ser Gln
 705                 710                 715                 720
 Ser Ser Ala Ser Gln Pro Arg Leu Ser Tyr Ala Glu Met Ala Glu Asp
                 725                 730                 735    
 Tyr Pro Arg Tyr Pro Asp Ile His Asp Leu Asp Leu Thr Leu Leu Asn
             740                 745                 750        
 Pro Arg Met Ile Val Asp Val Thr Pro Tyr Met Asn Pro Ser Pro Phe
         755                 760                 765            
 Thr Val Ser Pro Asn Thr His Val Ser Gln Val Phe Asn Leu Phe Arg
     770                 775                 780                
 Thr Met Gly Leu Arg His Leu Pro Val Val Asn Ala Val Gly Glu Ile
 785                 790                 795                 800
 Val Gly Ile Ile Thr Arg His Asn Leu Thr Tyr Glu Phe Leu Gln Ala
                 805                 810                 815    
 Arg Leu Arg Gln His Tyr Gln Thr Ile
             820                 825



      <210> 1372
      <211> 199
      <212> PRT
      <213> Homo sapiens


      <400> 1372
 Met Gly Ser Leu Leu Leu Leu Trp Lys Pro His Trp Lys Gly Ser Gly
   1               5                  10                  15    
 Leu Gly Val Arg Arg Phe Gln Ser Val Ser Trp Cys Cys Pro Gly Pro
              20                  25                  30        
 Gly Pro Ala Ala Pro Lys His Arg Gly Met Ser Gly Glu Asn Val Thr
          35                  40                  45            
 Arg Val Gly Thr Phe Ile Leu Val Gly Phe Pro Thr Ala Pro Gly Leu
      50                  55                  60                
 Gln Tyr Leu Leu Phe Leu Leu Phe Leu Leu Thr Tyr Leu Phe Val Leu
  65                  70                  75                  80
 Val Glu Asn Leu Ala Ile Ile Leu Thr Val Trp Ser Ser Thr Ser Leu
                  85                  90                  95    
 His Arg Pro Met Tyr Tyr Phe Leu Ser Ser Met Ser Phe Leu Glu Ile
             100                 105                 110        
 Trp Tyr Val Ser Asp Ile Thr Pro Lys Met Leu Glu Gly Phe Leu Leu
         115                 120                 125            
 Gln Gln Lys Arg Ile Ser Phe Val Gly Cys Met Thr Gln Leu Tyr Phe
     130                 135                 140                
 Phe Ser Ser Leu Val Cys Thr Glu Cys Val Leu Leu Ala Ser Met Ala
 145                 150                 155                 160
 Tyr Asp Arg Tyr Val Ala Ile Cys His Pro Leu Arg Tyr His Val Leu
                 165                 170                 175    
 Val Thr Pro Gly Leu Cys Leu Gln Leu Arg His Val Leu Trp Leu Gln
             180                 185                 190        
 Arg Leu Glu Pro Leu Leu Leu
         195                



      <210> 1373
      <211> 259
      <212> PRT
      <213> Homo sapiens


      <400> 1373
 Met Lys Thr Phe Phe Tyr Phe Ile Ser Val Ile Asn Leu Ile Ile Ile
   1               5                  10                  15    
 Cys Val Asp Ser Asp Leu Ser Gln Lys Val Tyr Asp Thr Leu Leu Lys
              20                  25                  30        
 Ser Ile Lys Lys Asn Leu Lys Gln Gly Val Cys Val Asp Ile Lys Asp
          35                  40                  45            
 Val Ile Ile Trp Gly Asn Ile Ser Gly Asn Asn Tyr Val Asp Leu Arg
      50                  55                  60                
 Lys Thr Arg Val Tyr Arg Tyr Glu Ser Ala Ile Trp Gly Pro Leu His
  65                  70                  75                  80
 Tyr Ser Arg Pro Val Leu Asn Leu Ile Phe Asp Ser Glu Trp Val Lys
                  85                  90                  95    
 Arg Glu Phe Val Ala Ile Leu Lys Asn Leu Thr Thr Thr Gly Arg Gln
             100                 105                 110        
 Phe Gly Gly Ile Leu Ala Ala His Ser Ile Ala Thr Thr Leu Lys Tyr
         115                 120                 125            
 Trp Tyr His Gly Ser Pro Pro Gly Glu Ile Val Ser Leu Gly Ile Leu
     130                 135                 140                
 Ser Glu Gly Gln Phe Gly Ile Pro Lys Gly Ile Val Phe Ser Met Pro
 145                 150                 155                 160
 Val Lys Phe Glu Asn Gly Thr Trp Val Val Leu Thr Asp Leu Lys Asp
                 165                 170                 175    
 Val Glu Ile Ser Glu Gln Ile Met Thr Arg Met Thr Ser Asp Leu Ile
             180                 185                 190        
 Gln Glu Lys Leu Val Ala Leu Gly Asp Lys Ile His Phe Gln Pro Tyr
         195                 200                 205            
 Gln Ser Gly His Lys Asp Leu Val Pro Asp Glu Glu Lys Asn Leu Ala
     210                 215                 220                
 Met Ser Asp Ala Ala Glu Phe Pro Asn Gln Ile Pro Gln Thr Thr Phe
 225                 230                 235                 240
 Glu Lys Pro Gln Ser Leu Glu Phe Leu Asn Glu Phe Glu Gly Lys Thr
                 245                 250                 255    
 Val Glu Ser
            



      <210> 1374
      <211> 450
      <212> PRT
      <213> Homo sapiens


      <400> 1374
 Met Glu Gly Ser Gly Gly Gly Ala Gly Glu Arg Ala Pro Leu Leu Gly
   1               5                  10                  15    
 Ala Arg Arg Ala Ala Ala Ala Ala Ala Ala Ala Gly Ala Phe Ala Gly
              20                  25                  30        
 Arg Arg Ala Ala Cys Gly Ala Val Leu Leu Thr Glu Leu Leu Glu Arg
          35                  40                  45            
 Ala Ala Phe Tyr Gly Ile Thr Ser Asn Leu Val Leu Phe Leu Asn Gly
      50                  55                  60                
 Ala Pro Phe Cys Trp Glu Gly Ala Gln Ala Ser Glu Ala Leu Leu Leu
  65                  70                  75                  80
 Phe Met Gly Leu Thr Tyr Leu Gly Ser Pro Phe Gly Gly Trp Leu Ala
                  85                  90                  95    
 Asp Ala Arg Leu Gly Arg Ala Arg Ala Ile Leu Leu Ser Leu Ala Leu
             100                 105                 110        
 Tyr Leu Leu Gly Met Leu Ala Phe Pro Leu Leu Ala Ala Pro Ala Thr
         115                 120                 125            
 Arg Ala Ala Leu Cys Gly Ser Ala Arg Leu Leu Asn Cys Thr Ala Pro
     130                 135                 140                
 Gly Pro Asp Ala Ala Ala Arg Cys Cys Ser Pro Ala Thr Phe Ala Gly
 145                 150                 155                 160
 Leu Val Leu Val Gly Leu Gly Val Ala Thr Val Lys Ala Asn Ile Thr
                 165                 170                 175    
 Pro Phe Gly Ala Asp Gln His Leu Pro Glu Gly Arg Asn Thr Val Ser
             180                 185                 190        
 Ser Ile Ala Glu Glu Val Glu Gly Met Ser Ser Pro Pro Lys Thr Phe
         195                 200                 205            
 Glu Gly Met Asn Ala Ala Ser Ser Ile Ala Glu Glu Ser Arg Arg Lys
     210                 215                 220                
 Gly His Ser Ala Asp Thr Val Ser Pro Asp Val Cys Leu Pro Glu Pro
 225                 230                 235                 240
 Glu Glu Gly Pro Leu Cys Asp Thr Ala Ser Pro Glu Val Cys Pro Pro
                 245                 250                 255    
 Glu Pro Glu Glu Gly Pro Leu Cys Asp Thr Ser Arg Arg Lys Gly Pro
             260                 265                 270        
 Ser Val Thr Pro Arg Ala Arg Thr Ser Val Leu Gln Ser Arg Arg Lys
         275                 280                 285            
 Gly His Ser Ala Asp Thr Gly Ile Pro Asp Val Cys Pro Pro Glu Ala
     290                 295                 300                
 Glu Glu Gly Pro Leu Cys Asp Thr Ala Ile Pro Asp Val Cys Pro Pro
 305                 310                 315                 320
 Glu Ala Glu Glu Gly Pro Leu Cys Asp Thr Thr Ser Pro Asp Ser Arg
                 325                 330                 335    
 Arg Lys Gly Pro Ser Ala Asp Thr Ala Ser Pro Asp Val Cys Pro Pro
             340                 345                 350        
 Glu Pro Glu Glu Gly Pro Leu Cys Asp Thr Ala Ser Pro Asp Val Cys
         355                 360                 365            
 Pro Pro Glu Pro Glu Glu Gly Pro Leu Cys Asp Thr Ala Ser Pro Asp
     370                 375                 380                
 Val Cys Pro Pro Glu Pro Glu Glu Gly Pro Leu Cys Asp Thr Gly Ile
 385                 390                 395                 400
 His Asn Met Ala Ala Cys Phe Pro Gln Ser Glu Arg Leu Glu Arg Asp
                 405                 410                 415    
 Thr Pro Arg Ser Ser Glu Arg Ala Cys Ala Thr Trp Lys Pro Glu Thr
             420                 425                 430        
 Asp Cys Asn Arg Leu Gln Lys Ser Tyr Pro Ile Thr Phe Ala Arg Phe
         435                 440                 445            
 Asp Tyr
     450



      <210> 1375
      <211> 333
      <212> PRT
      <213> Homo sapiens


      <400> 1375
 Met Asn Leu Ser Leu Val Leu Ala Ala Phe Cys Leu Gly Ile Ala Ser
   1               5                  10                  15    
 Ala Val Pro Lys Phe Asp Gln Asn Leu Asp Thr Lys Trp Tyr Gln Trp
              20                  25                  30        
 Lys Ala Thr His Arg Arg Leu Tyr Gly Ala Asn Glu Glu Gly Trp Arg
          35                  40                  45            
 Arg Ala Val Trp Glu Lys Asn Met Lys Met Ile Glu Leu His Asn Gly
      50                  55                  60                
 Glu Tyr Ser Gln Gly Lys His Ser Phe Thr Met Ala Met Asn Ala Phe
  65                  70                  75                  80
 Gly Asp Met Thr Asn Glu Glu Phe Arg Gln Val Met Asn Gly Phe Gln
                  85                  90                  95    
 Tyr Gln Lys His Arg Lys Gly Lys Gln Phe Gln Glu Arg Leu Leu Leu
             100                 105                 110        
 Glu Ile Pro Thr Ser Val Asp Trp Arg Glu Lys Gly Tyr Met Thr Pro
         115                 120                 125            
 Val Lys Asp Gln Gly Gln Cys Gly Ser Cys Trp Ala Phe Ser Ala Thr
     130                 135                 140                
 Gly Ala Leu Glu Gly Gln Met Phe Trp Lys Thr Gly Lys Leu Ile Ser
 145                 150                 155                 160
 Leu Asn Glu Gln Asn Leu Val Asp Cys Ser Gly Pro Gln Gly Asn Glu
                 165                 170                 175    
 Gly Cys Asn Gly Asp Phe Met Asp Asn Pro Phe Arg Tyr Val Gln Glu
             180                 185                 190        
 Asn Gly Gly Leu Asp Ser Glu Glu Ser Tyr Pro Tyr Glu Ala Thr Glu
         195                 200                 205            
 Glu Ser Cys Lys Tyr Asn Pro Lys Tyr Ser Val Ala Asn Asp Thr Gly
     210                 215                 220                
 Phe Val Asp Ile Pro Lys Gln Glu Lys Ala Leu Met Lys Ala Val Ala
 225                 230                 235                 240
 Thr Val Gly Pro Ile Ser Val Ala Ile Asp Ala Gly His Glu Ser Phe
                 245                 250                 255    
 Leu Phe Tyr Lys Glu Gly Ile Tyr Phe Glu Pro Asp Cys Ser Ser Glu
             260                 265                 270        
 Asp Met Asp His Gly Val Leu Val Val Gly Tyr Gly Phe Glu Ser Thr
         275                 280                 285            
 Glu Ser Asp Asn Asn Lys Tyr Trp Leu Val Lys Asn Ser Trp Gly Glu
     290                 295                 300                
 Glu Trp Gly Met Gly Gly Tyr Val Lys Met Ala Lys Asp Arg Arg Asn
 305                 310                 315                 320
 His Cys Gly Ile Ala Ser Ala Ala Ser Tyr Pro Thr Val
                 325                 330            



      <210> 1376
      <211> 580
      <212> PRT
      <213> Homo sapiens


      <400> 1376
 Met Thr Ser Thr Cys Thr Asn Ser Thr Arg Glu Ser Asn Ser Ser His
   1               5                  10                  15    
 Thr Cys Met Pro Leu Ser Lys Met Pro Ile Ser Leu Ala His Gly Ile
              20                  25                  30        
 Ile Arg Ser Thr Val Leu Val Ile Phe Leu Ala Ala Ser Phe Val Gly
          35                  40                  45            
 Asn Ile Val Leu Ala Leu Val Leu Gln Arg Lys Pro Gln Leu Leu Gln
      50                  55                  60                
 Val Thr Asn Arg Phe Ile Phe Asn Leu Leu Val Thr Asp Leu Leu Gln
  65                  70                  75                  80
 Ile Ser Leu Val Ala Pro Trp Val Val Ala Thr Ser Val Pro Leu Phe
                  85                  90                  95    
 Trp Pro Leu Asn Ser His Phe Cys Thr Ala Leu Val Ser Leu Thr His
             100                 105                 110        
 Leu Phe Ala Phe Ala Ser Val Asn Thr Ile Val Val Val Ser Val Asp
         115                 120                 125            
 Arg Tyr Leu Ser Ile Ile His Pro Leu Ser Tyr Pro Ser Lys Met Thr
     130                 135                 140                
 Gln Arg Arg Gly Tyr Leu Leu Leu Tyr Gly Thr Trp Ile Val Ala Ile
 145                 150                 155                 160
 Leu Gln Ser Thr Pro Pro Leu Tyr Gly Trp Gly Gln Ala Ala Phe Asp
                 165                 170                 175    
 Glu Arg Asn Ala Leu Cys Ser Met Ile Trp Gly Ala Ser Pro Ser Tyr
             180                 185                 190        
 Thr Ile Leu Ser Val Val Ser Phe Ile Val Ile Pro Leu Ile Val Met
         195                 200                 205            
 Ile Ala Cys Tyr Ser Val Val Phe Cys Ala Ala Arg Arg Gln His Ala
     210                 215                 220                
 Leu Leu Tyr Asn Val Lys Arg His Ser Leu Glu Val Arg Val Lys Asp
 225                 230                 235                 240
 Cys Val Glu Asn Glu Asp Glu Glu Gly Ala Glu Lys Lys Glu Glu Phe
                 245                 250                 255    
 Gln Asp Glu Ser Glu Phe Arg Arg Gln His Glu Gly Glu Val Lys Ala
             260                 265                 270        
 Lys Glu Gly Arg Met Glu Ala Lys Asp Gly Ser Leu Lys Ala Lys Glu
         275                 280                 285            
 Gly Ser Thr Gly Thr Ser Glu Ser Ser Val Glu Ala Arg Gly Ser Glu
     290                 295                 300                
 Glu Val Arg Glu Ser Ser Thr Val Ala Ser Asp Gly Ser Met Glu Gly
 305                 310                 315                 320
 Lys Glu Gly Ser Thr Lys Val Glu Glu Asn Ser Met Lys Ala Asp Lys
                 325                 330                 335    
 Gly Arg Thr Glu Val Asn Gln Cys Ser Ile Asp Leu Gly Glu Asp Asp
             340                 345                 350        
 Met Glu Phe Gly Glu Asp Asp Ile Asn Phe Ser Glu Asp Asp Val Glu
         355                 360                 365            
 Ala Val Asn Ile Pro Glu Ser Leu Pro Pro Ser Arg Arg Asn Ser Asn
     370                 375                 380                
 Ser Asn Pro Pro Leu Pro Arg Cys Tyr Gln Cys Lys Ala Ala Lys Val
 385                 390                 395                 400
 Ile Phe Ile Ile Ile Phe Ser Tyr Val Leu Ser Leu Gly Pro Tyr Cys
                 405                 410                 415    
 Phe Leu Ala Val Leu Ala Val Trp Val Asp Val Glu Thr Gln Val Pro
             420                 425                 430        
 Gln Trp Val Ile Thr Ile Ile Ile Trp Leu Phe Phe Leu Gln Cys Cys
         435                 440                 445            
 Ile His Pro Tyr Val Tyr Gly Tyr Met His Lys Thr Ile Lys Lys Glu
     450                 455                 460                
 Ile Gln Asp Met Leu Lys Lys Phe Phe Cys Lys Glu Lys Pro Pro Lys
 465                 470                 475                 480
 Glu Asp Ser His Pro Asp Leu Pro Gly Thr Glu Val Ser Ser Lys Ala
                 485                 490                 495    
 Asn Leu Glu Leu Ser Ile Thr Arg Glu Thr Arg Gly Asp Phe Phe Ser
             500                 505                 510        
 Met Asp Pro Gln Phe Ile Asn Ala Lys Pro Tyr His Phe Arg Gln Arg
         515                 520                 525            
 Lys Gly Lys Met Met Leu Val Asn Leu Arg Thr Phe Arg Pro Ser Gly
     530                 535                 540                
 Arg Glu Leu Met Gly Gln Ser Tyr Ser Leu Cys Ser Thr Glu Arg Lys
 545                 550                 555                 560
 Ala Met Asp Gln Ile Ile His Gly Ala Gln Glu Thr Glu Pro Asn Gly
                 565                 570                 575    
 Leu Ile Asn Ile
             580



      <210> 1377
      <211> 90
      <212> PRT
      <213> Homo sapiens


      <400> 1377
 Met Leu Phe Pro Ala Ala Phe Ile Gly Leu Phe Val Phe Leu Tyr Gly
   1               5                  10                  15    
 Val Thr Thr Leu Asp His Ser Gln Val Ser Lys Glu Val Cys Gln Ala
              20                  25                  30        
 Thr Asp Ile Ile Met Cys Pro Val Cys Asp Lys Tyr Cys Pro Phe Met
          35                  40                  45            
 Arg Leu Ser Asp Ser Cys Val Tyr Ala Lys Val Ile Ser Asn Cys Ser
      50                  55                  60                
 Ile Leu Asp Glu Leu Asn Leu Thr Tyr Thr Phe Leu Arg Asp Gly Leu
  65                  70                  75                  80
 Ile Leu Ala Glu Gly Val Ile Ser Leu Ser
                  85                  90



      <210> 1378
      <211> 544
      <212> PRT
      <213> Homo sapiens


      <400> 1378
 Met Val Lys Ser Ser Glu Thr Thr Ser Gly Asn Ile Ala Phe Ile Val
   1               5                  10                  15    
 Glu Leu Leu Lys Asn Ile Ser Thr Asp Leu Ser Asp Asn Val Thr Arg
              20                  25                  30        
 Glu Lys Met Lys Ser Tyr Ser Glu Val Ala Asn His Ile Leu Asp Thr
          35                  40                  45            
 Ala Ala Ile Ser Asn Trp Ala Phe Ile Pro Asn Lys Asn Ala Ser Ser
      50                  55                  60                
 Asp Leu Leu Gln Ser Val Asn Leu Phe Ala Arg Gln Leu His Ile His
  65                  70                  75                  80
 Asn Asn Ser Glu Asn Ile Val Asn Glu Leu Phe Ile Gln Thr Lys Gly
                  85                  90                  95    
 Phe His Ile Asn His Asn Thr Ser Glu Lys Ser Leu Asn Phe Ser Met
             100                 105                 110        
 Ser Met Asn Asn Thr Thr Glu Asp Ile Leu Gly Met Val Gln Ile Pro
         115                 120                 125            
 Arg Gln Glu Leu Arg Lys Leu Trp Pro Asn Ala Ser Gln Ala Ile Ser
     130                 135                 140                
 Ile Ala Phe Pro Thr Leu Gly Ala Ile Leu Arg Glu Ala His Leu Gln
 145                 150                 155                 160
 Asn Val Ser Leu Pro Arg Gln Val Asn Gly Leu Val Leu Ser Val Val
                 165                 170                 175    
 Leu Pro Glu Arg Leu Gln Glu Ile Ile Leu Thr Phe Glu Lys Ile Asn
             180                 185                 190        
 Lys Thr Arg Asn Ala Arg Ala Gln Cys Val Gly Trp His Ser Lys Lys
         195                 200                 205            
 Arg Arg Trp Asp Glu Lys Ala Cys Gln Met Met Leu Asp Ile Arg Asn
     210                 215                 220                
 Glu Val Lys Cys Arg Cys Asn Tyr Thr Ser Val Val Met Ser Phe Ser
 225                 230                 235                 240
 Ile Leu Met Ser Ser Lys Ser Met Thr Asp Lys Val Leu Asp Tyr Ile
                 245                 250                 255    
 Thr Cys Ile Gly Leu Ser Val Ser Ile Leu Ser Leu Val Leu Cys Leu
             260                 265                 270        
 Ile Ile Glu Ala Thr Val Trp Ser Arg Val Val Val Thr Glu Ile Ser
         275                 280                 285            
 Tyr Met Arg His Val Cys Ile Val Asn Ile Ala Val Ser Leu Leu Thr
     290                 295                 300                
 Ala Asn Val Trp Phe Ile Ile Gly Ser His Phe Asn Ile Lys Ala Gln
 305                 310                 315                 320
 Asp Tyr Asn Met Cys Val Ala Val Thr Phe Phe Ser His Phe Phe Tyr
                 325                 330                 335    
 Leu Ser Leu Phe Phe Trp Met Leu Phe Lys Ala Leu Leu Ile Ile Tyr
             340                 345                 350        
 Gly Ile Leu Val Ile Phe Arg Arg Met Met Lys Ser Arg Met Met Val
         355                 360                 365            
 Ile Gly Phe Ala Ile Gly Tyr Gly Cys Pro Leu Ile Ile Ala Val Thr
     370                 375                 380                
 Thr Val Ala Ile Thr Glu Pro Glu Lys Gly Tyr Met Arg Pro Glu Ala
 385                 390                 395                 400
 Cys Trp Leu Asn Trp Asp Asn Thr Lys Ala Leu Leu Ala Phe Ala Ile
                 405                 410                 415    
 Pro Ala Phe Val Ile Val Ala Val Asn Leu Ile Val Val Leu Val Val
             420                 425                 430        
 Ala Val Asn Thr Gln Arg Pro Ser Ile Gly Ser Ser Lys Ser Gln Asp
         435                 440                 445            
 Val Val Ile Ile Met Arg Ile Ser Lys Asn Val Ala Ile Leu Thr Pro
     450                 455                 460                
 Leu Leu Gly Leu Thr Trp Gly Phe Gly Ile Ala Thr Leu Ile Glu Gly
 465                 470                 475                 480
 Thr Ser Leu Thr Phe His Ile Ile Phe Ala Leu Leu Asn Ala Phe Gln
                 485                 490                 495    
 Ile Arg Asp Ala Leu Arg Met Arg Met Ser Ser Leu Lys Gly Lys Ser
             500                 505                 510        
 Arg Ala Ala Glu Pro Trp Arg Val Arg Val Leu Ala Gly Tyr Ala Glu
         515                 520                 525            
 Thr Asn Thr Ile Ala Gln Tyr Ser Gly Ser Val Gly Lys Glu Asp Gln
     530                 535                 540                





      <210> 1379
      <211> 65
      <212> PRT
      <213> Homo sapiens


      <400> 1379
 Met Leu Val Tyr Gln Asn Gln Ala Gln Phe Ser Ser Asn Met Trp Leu
   1               5                  10                  15    
 Asn Phe Ser Asp Val His Thr Tyr Leu Ser Ser Ile Ala Leu Leu Cys
              20                  25                  30        
 Phe Cys Leu Ser Gly Val Leu Cys Cys Ile Cys Asn Asn Ser Val Phe
          35                  40                  45            
 His Ile Gln Gln Tyr Ile Leu Ile Ile Ile Thr Phe Pro Leu Val Val
      50                  55                  60                
 Ile
  65



      <210> 1380
      <211> 336
      <212> PRT
      <213> Homo sapiens


      <400> 1380
 Met Leu Arg Gly Gln Ala Ser Lys Arg Arg Ala Arg Glu Lys Arg Arg
   1               5                  10                  15    
 Gln Ala Arg Gly Glu Asp Gln Cys Leu Gly Gly Ala Gln Ala Thr Ala
              20                  25                  30        
 Ala Glu Lys Glu Lys Leu Pro Ser Ser Ser Ser Pro Glu Cys Gln Ile
          35                  40                  45            
 Leu Pro Arg Ala Ser Pro Asn Ala Gly Ile Pro Gln Glu Ser Gln Arg
      50                  55                  60                
 Ala Ser Tyr Pro Ser Ser Pro Ala Ser Ala Val Ser Leu Thr Ser Ser
  65                  70                  75                  80
 Asp Glu Gly Ala Lys Gly Gln Lys Gly Glu Ser Pro Asn Ser Phe His
                  85                  90                  95    
 Gly Pro Ser Ser Ser Glu Ser Thr Gly Arg Asp Leu Leu Asn Thr Lys
             100                 105                 110        
 Thr Gly Glu Leu Val Gln Phe Leu Leu Asn Lys Tyr Ile Arg Lys Glu
         115                 120                 125            
 Pro Ile Thr Arg Glu Ala Met Leu Lys Val Ile Asn Arg Lys Tyr Lys
     130                 135                 140                
 Gln His Phe Pro Glu Ile Leu Arg Arg Ser Thr Glu Asn Val Glu Val
 145                 150                 155                 160
 Val Phe Gly Leu Tyr Leu Lys Glu Met Asp Pro Ser Arg Gln Ser Tyr
                 165                 170                 175    
 Val Leu Val Gly Lys Leu Asp Phe Pro Asn Gln Gly Ser Leu Ser Asp
             180                 185                 190        
 Gly Gly Gly Phe Pro Leu Ser Gly Leu Leu Met Val Leu Leu Ser Thr
         195                 200                 205            
 Ile Phe Met His Gly Asn Arg Ala Thr Glu Glu Glu Met Trp Glu Cys
     210                 215                 220                
 Leu Asn Ala Leu Gly Met Tyr Lys Gly Arg Lys His Phe Ile Tyr Gly
 225                 230                 235                 240
 Glu Pro Gln Glu Leu Val Thr Lys Asp Leu Val Arg Glu Gly Tyr Leu
                 245                 250                 255    
 Glu Tyr Gln Gln Val Pro Ser Ser Asp Pro Pro Arg Tyr Glu Phe Leu
             260                 265                 270        
 Trp Gly Pro Arg Ala Arg Ala Glu Thr Ser Lys Met Lys Val Leu Glu
         275                 280                 285            
 Phe Val Ala Lys Leu Asn Asp Thr Val Ala Ser Thr Tyr Lys Ser Arg
     290                 295                 300                
 Tyr Glu Glu Ala Leu Arg Glu Glu Glu Glu Gln Ala Arg Ala Arg Ala
 305                 310                 315                 320
 Val Ala Arg Asp Ser Ala Arg Ala Arg Ala Ser Arg Ser Phe Gln Pro
                 325                 330                 335    





      <210> 1381
      <211> 543
      <212> PRT
      <213> Homo sapiens


      <400> 1381
 Met Glu Asp Gly Phe Lys Gly Asp Arg Thr Glu Gly Cys Arg Ser Asp
   1               5                  10                  15    
 Ser Val Ala Val Pro Ala Ala Ala Pro Val Cys Gln Pro Lys Ser Ala
              20                  25                  30        
 Thr Asn Gly Gln Pro Pro Ala Pro Ala Pro Thr Pro Thr Pro Arg Leu
          35                  40                  45            
 Ser Ile Ser Ser Arg Ala Thr Val Val Ala Arg Met Glu Gly Thr Ser
      50                  55                  60                
 Gln Gly Gly Leu Gln Thr Val Met Lys Trp Lys Thr Val Val Ala Ile
  65                  70                  75                  80
 Phe Val Val Val Val Val Tyr Leu Val Thr Gly Gly Leu Val Phe Arg
                  85                  90                  95    
 Ala Leu Glu Gln Pro Phe Glu Ser Ser Gln Lys Asn Thr Ile Ala Leu
             100                 105                 110        
 Glu Lys Ala Glu Phe Leu Arg Asp His Val Cys Val Ser Pro Gln Glu
         115                 120                 125            
 Leu Glu Thr Leu Ile Gln His Ala Leu Asp Ala Asp Asn Ala Gly Val
     130                 135                 140                
 Ser Pro Ile Gly Asn Ser Ser Asn Asn Ser Ser His Trp Asp Leu Gly
 145                 150                 155                 160
 Ser Ala Phe Phe Phe Ala Gly Thr Val Ile Thr Thr Ile Gly Tyr Gly
                 165                 170                 175    
 Asn Ile Ala Pro Ser Thr Glu Gly Gly Lys Ile Phe Cys Ile Leu Tyr
             180                 185                 190        
 Ala Ile Phe Gly Ile Pro Leu Phe Gly Phe Leu Leu Ala Gly Ile Gly
         195                 200                 205            
 Asp Gln Leu Gly Thr Ile Phe Gly Lys Ser Ile Ala Arg Val Glu Lys
     210                 215                 220                
 Val Phe Arg Lys Lys Gln Val Ser Gln Thr Lys Ile Arg Val Ile Ser
 225                 230                 235                 240
 Thr Ile Leu Phe Ile Leu Ala Gly Cys Ile Val Phe Val Thr Ile Pro
                 245                 250                 255    
 Ala Val Ile Phe Lys Tyr Ile Glu Gly Trp Thr Ala Leu Glu Ser Ile
             260                 265                 270        
 Tyr Phe Val Val Val Thr Leu Thr Thr Val Gly Phe Gly Asp Phe Val
         275                 280                 285            
 Ala Gly Gly Asn Ala Gly Ile Asn Tyr Arg Glu Trp Tyr Lys Pro Leu
     290                 295                 300                
 Val Trp Phe Trp Ile Leu Val Gly Leu Ala Tyr Phe Ala Ala Val Leu
 305                 310                 315                 320
 Ser Met Ile Gly Asp Trp Leu Arg Val Leu Ser Lys Lys Thr Lys Glu
                 325                 330                 335    
 Glu Val Gly Glu Ile Lys Ala His Ala Ala Glu Trp Lys Ala Asn Val
             340                 345                 350        
 Thr Ala Glu Phe Arg Glu Thr Arg Arg Arg Leu Ser Val Glu Ile His
         355                 360                 365            
 Asp Lys Leu Gln Arg Ala Ala Thr Ile Arg Ser Met Glu Arg Arg Arg
     370                 375                 380                
 Leu Gly Leu Asp Gln Arg Ala His Ser Leu Asp Met Leu Ser Pro Glu
 385                 390                 395                 400
 Lys Arg Ser Val Phe Ala Ala Leu Asp Thr Gly Arg Phe Lys Ala Ser
                 405                 410                 415    
 Ser Gln Glu Ser Ile Asn Asn Arg Pro Asn Asn Leu Arg Leu Lys Gly
             420                 425                 430        
 Pro Glu Gln Leu Asn Lys His Gly Gln Gly Ala Ser Glu Asp Asn Ile
         435                 440                 445            
 Ile Asn Lys Phe Gly Ser Thr Ser Arg Leu Thr Lys Arg Lys Asn Lys
     450                 455                 460                
 Asp Leu Lys Lys Thr Leu Pro Glu Asp Val Gln Lys Ile Tyr Lys Thr
 465                 470                 475                 480
 Phe Arg Asn Tyr Ser Leu Asp Glu Glu Lys Lys Glu Glu Glu Thr Glu
                 485                 490                 495    
 Lys Met Cys Asn Ser Asp Asn Ser Ser Thr Ala Met Leu Thr Asp Cys
             500                 505                 510        
 Ile Gln Gln His Ala Glu Leu Glu Asn Gly Met Ile Pro Thr Asp Thr
         515                 520                 525            
 Lys Asp Arg Glu Pro Glu Asn Asn Ser Leu Leu Glu Asp Arg Asn
     530                 535                 540            



      <210> 1382
      <211> 538
      <212> PRT
      <213> Homo sapiens


      <400> 1382
 Met Arg Val Gly Gly Ala Phe His Leu Leu Leu Val Cys Leu Ser Pro
   1               5                  10                  15    
 Ala Leu Leu Ser Ala Val Arg Ile Asn Gly Asp Gly Gln Glu Val Leu
              20                  25                  30        
 Tyr Leu Ala Glu Gly Asp Asn Val Arg Leu Gly Cys Pro Tyr Val Leu
          35                  40                  45            
 Asp Pro Glu Asp Tyr Gly Pro Asn Gly Leu Asp Ile Glu Trp Met Gln
      50                  55                  60                
 Val Asn Ser Asp Pro Ala His His Arg Glu Asn Val Phe Leu Ser Tyr
  65                  70                  75                  80
 Gln Asp Lys Arg Ile Asn His Gly Ser Leu Pro His Leu Gln Gln Arg
                  85                  90                  95    
 Val Arg Phe Ala Ala Ser Asp Pro Ser Gln Tyr Asp Ala Ser Ile Asn
             100                 105                 110        
 Leu Met Asn Leu Gln Val Ser Asp Thr Ala Thr Tyr Glu Cys Arg Val
         115                 120                 125            
 Lys Lys Thr Thr Met Ala Thr Arg Lys Val Ile Val Thr Val Gln Ala
     130                 135                 140                
 Arg Pro Ala Val Pro Met Cys Trp Thr Glu Gly His Met Thr Tyr Gly
 145                 150                 155                 160
 Asn Asp Val Val Leu Lys Cys Tyr Ala Ser Gly Gly Ser Gln Pro Leu
                 165                 170                 175    
 Ser Tyr Lys Trp Ala Lys Ile Ser Gly His His Tyr Pro Tyr Arg Ala
             180                 185                 190        
 Gly Ser Tyr Thr Ser Gln His Ser Tyr His Ser Glu Leu Ser Tyr Gln
         195                 200                 205            
 Glu Ser Phe His Ser Ser Ile Asn Gln Gly Leu Asn Asn Gly Asp Leu
     210                 215                 220                
 Val Leu Lys Asp Ile Ser Arg Ala Asp Asp Gly Leu Tyr Gln Cys Thr
 225                 230                 235                 240
 Val Ala Asn Asn Val Gly Tyr Ser Val Cys Val Val Glu Val Lys Val
                 245                 250                 255    
 Ser Asp Ser Arg Arg Ile Gly Val Ile Ile Gly Ile Val Leu Gly Ser
             260                 265                 270        
 Leu Leu Ala Leu Gly Cys Leu Ala Val Gly Ile Trp Gly Leu Val Cys
         275                 280                 285            
 Cys Cys Cys Gly Gly Ser Gly Ala Gly Gly Ala Arg Gly Ala Phe Gly
     290                 295                 300                
 Tyr Gly Asn Gly Gly Gly Val Gly Gly Gly Ala Cys Gly Asp Leu Ala
 305                 310                 315                 320
 Ser Glu Ile Arg Glu Asp Ala Val Ala Pro Gly Cys Lys Ala Ser Gly
                 325                 330                 335    
 Arg Gly Ser Arg Val Thr His Leu Leu Gly Tyr Pro Thr Gln Asn Val
             340                 345                 350        
 Ser Arg Ser Leu Arg Arg Lys Tyr Ala Pro Pro Pro Cys Gly Gly Pro
         355                 360                 365            
 Glu Asp Val Ala Leu Ala Pro Cys Thr Ala Ala Ala Ala Cys Glu Ala
     370                 375                 380                
 Gly Pro Ser Pro Val Tyr Val Lys Val Lys Ser Ala Glu Pro Ala Asp
 385                 390                 395                 400
 Cys Ala Glu Gly Pro Val Gln Cys Lys Asn Gly Leu Leu Val Ser Ser
                 405                 410                 415    
 Pro His Cys Glu Glu Pro Cys Ala His Ser Cys Ala His Pro Gly Leu
             420                 425                 430        
 Pro Pro His Leu Val His Lys Leu Pro Leu Ser Tyr Leu Gln Thr Gln
         435                 440                 445            
 Asp Thr Asp Ala Ala Ser Arg Arg Ile Asn Ala Pro Leu Ala Ala Gly
     450                 455                 460                
 Trp Ser Trp Leu Arg Leu Trp Leu Val Thr Leu Ala Ser Gly Val Asp
 465                 470                 475                 480
 Phe Pro Gln Val Ser Ala Trp Met Arg Ala Leu Pro Ser Pro Asp Cys
                 485                 490                 495    
 Pro Gly Leu Arg Thr Thr Gly Glu Gln Met Gln Lys Leu Leu Leu Lys
             500                 505                 510        
 Glu Asn Lys Val Lys Thr Arg Lys Ser Lys Arg Arg Ser Gly Glu Gly
         515                 520                 525            
 Ser His Leu Thr Thr Ser Ile Leu Glu Gln
     530                 535            



      <210> 1383
      <211> 186
      <212> PRT
      <213> Homo sapiens


      <400> 1383
 Met Asp Arg Phe Arg Ala Ala Val Gly Ala Ala Cys Gly Leu Ala Leu
   1               5                  10                  15    
 Asp Thr Glu Pro Pro Pro Ala Gln Gly Leu Leu Leu Ala Val Pro Cys
              20                  25                  30        
 Ala Trp Glu His Asp Phe Arg Arg Val Ser Asn Leu Ser Gln Tyr Phe
          35                  40                  45            
 Ser Pro Ala Ser Val Ser Ser Ser Pro Ala Arg Ala Leu Leu Leu Val
      50                  55                  60                
 Gly Val Val Leu Leu Ala Tyr Trp Phe Leu Ser Leu Thr Leu Gly Phe
  65                  70                  75                  80
 Thr Phe Ser Val Leu His Val Val Phe Gly Arg Phe Phe Trp Ile Val
                  85                  90                  95    
 Arg Val Val Leu Phe Ser Met Ser Cys Val Tyr Ile Leu His Lys Tyr
             100                 105                 110        
 Glu Gly Glu Pro Glu Asn Ala Val Leu Pro Leu Cys Phe Val Val Ala
         115                 120                 125            
 Val Tyr Phe Met Thr Gly Pro Met Gly Phe Tyr Trp Arg Ser Ser Pro
     130                 135                 140                
 Ser Gly Pro Ser Asn Pro Ser Asn Pro Ser Val Glu Glu Lys Leu Glu
 145                 150                 155                 160
 His Leu Glu Lys Gln Val Arg Leu Leu Asn Ile Arg Leu Asn Arg Val
                 165                 170                 175    
 Leu Glu Ser Leu Asp Arg Ser Lys Asp Lys
             180                 185    



      <210> 1384
      <211> 337
      <212> PRT
      <213> Homo sapiens


      <400> 1384
 Met Ala Phe Phe Ser Arg Leu Asn Leu Gln Glu Gly Leu Gln Thr Phe
   1               5                  10                  15    
 Phe Val Leu Gln Trp Ile Pro Val Tyr Ile Phe Leu Gly Ala Ile Pro
              20                  25                  30        
 Ile Leu Leu Ile Pro Tyr Phe Leu Leu Phe Ser Lys Phe Trp Pro Leu
          35                  40                  45            
 Ala Val Leu Ser Leu Ala Trp Leu Thr Tyr Asp Trp Asn Thr His Ser
      50                  55                  60                
 Gln Gly Gly Arg Arg Ser Ala Trp Val Arg Asn Trp Thr Leu Trp Lys
  65                  70                  75                  80
 Tyr Phe Arg Asn Tyr Phe Pro Val Lys Leu Val Lys Thr His Asp Leu
                  85                  90                  95    
 Ser Pro Lys His Asn Tyr Ile Ile Ala Asn His Pro His Gly Ile Leu
             100                 105                 110        
 Ser Phe Gly Val Phe Ile Asn Phe Ala Thr Glu Ala Thr Gly Ile Ala
         115                 120                 125            
 Arg Ile Phe Pro Ser Ile Thr Pro Phe Val Gly Thr Leu Glu Arg Ile
     130                 135                 140                
 Phe Trp Ile Pro Ile Val Arg Glu Tyr Val Met Ser Met Gly Val Cys
 145                 150                 155                 160
 Pro Val Ser Ser Ser Ala Leu Lys Tyr Leu Leu Thr Gln Lys Gly Ser
                 165                 170                 175    
 Gly Asn Ala Val Val Ile Val Val Gly Gly Ala Ala Glu Ala Leu Leu
             180                 185                 190        
 Cys Arg Pro Gly Ala Ser Thr Leu Phe Leu Lys Gln Arg Lys Gly Phe
         195                 200                 205            
 Val Lys Met Ala Leu Gln Thr Gly Ala Tyr Leu Val Pro Ser Tyr Ser
     210                 215                 220                
 Phe Gly Glu Asn Glu Val Phe Asn Gln Glu Thr Phe Pro Glu Gly Thr
 225                 230                 235                 240
 Trp Leu Arg Leu Phe Gln Lys Thr Phe Gln Asp Thr Phe Lys Lys Ile
                 245                 250                 255    
 Leu Gly Leu Asn Phe Cys Thr Phe His Gly Arg Gly Phe Thr Arg Gly
             260                 265                 270        
 Ser Trp Gly Phe Leu Pro Phe Asn Arg Pro Ile Thr Thr Val Val Gly
         275                 280                 285            
 Glu Pro Leu Pro Ile Pro Arg Ile Lys Arg Pro Asn Gln Lys Thr Val
     290                 295                 300                
 Asp Lys Tyr His Ala Leu Tyr Ile Ser Ala Leu Arg Lys Leu Phe Asp
 305                 310                 315                 320
 Gln His Lys Val Glu Tyr Gly Leu Pro Glu Thr Gln Glu Leu Thr Ile
                 325                 330                 335    
 Thr
    



      <210> 1385
      <211> 255
      <212> PRT
      <213> Homo sapiens


      <400> 1385
 Met Arg Arg Ile Ser Leu Thr Ser Ser Pro Val Arg Leu Leu Leu Phe
   1               5                  10                  15    
 Leu Leu Leu Leu Leu Ile Ala Leu Glu Ile Met Val Gly Gly His Ser
              20                  25                  30        
 Leu Cys Phe Asn Phe Thr Ile Lys Ser Leu Ser Arg Pro Gly Gln Pro
          35                  40                  45            
 Trp Cys Glu Ala Gln Val Phe Leu Asn Lys Asn Leu Phe Leu Gln Tyr
      50                  55                  60                
 Asn Ser Asp Asn Asn Met Val Lys Pro Met Gly Leu Leu Gly Lys Lys
  65                  70                  75                  80
 Val Asn Ala Thr Ser Thr Trp Gly Glu Leu Thr Gln Thr Leu Gly Glu
                  85                  90                  95    
 Val Gly Arg Asp Leu Arg Met Leu Leu Cys Asp Ile Lys Pro Gln Ile
             100                 105                 110        
 Lys Thr Ser Asp Pro Ser Thr Leu Gln Val Glu Met Phe Cys Gln Arg
         115                 120                 125            
 Glu Ala Glu Arg Cys Thr Gly Ala Ser Trp Gln Phe Ala Thr Asn Gly
     130                 135                 140                
 Glu Lys Ser Leu Leu Phe Asp Ala Met Asn Met Thr Trp Thr Val Ile
 145                 150                 155                 160
 Asn His Glu Ala Ser Lys Ile Lys Glu Thr Trp Lys Lys Asp Arg Gly
                 165                 170                 175    
 Leu Glu Lys Tyr Phe Arg Lys Leu Ser Lys Gly Asp Cys Asp His Trp
             180                 185                 190        
 Leu Arg Glu Phe Leu Gly His Trp Glu Ala Met Pro Glu Pro Thr Val
         195                 200                 205            
 Ser Pro Val Asn Ala Ser Asp Ile His Trp Ser Ser Ser Ser Leu Pro
     210                 215                 220                
 Asp Arg Trp Ile Ile Leu Gly Ala Phe Ile Leu Leu Leu Leu Met Gly
 225                 230                 235                 240
 Ile Val Leu Ile Cys Val Trp Trp Gln Asn Gly Arg Arg Ser Thr
                 245                 250                 255



      <210> 1386
      <211> 52
      <212> PRT
      <213> Homo sapiens


      <400> 1386
 Met Lys Phe Leu Val Phe Ala Phe Ile Leu Ala Leu Met Val Ser Met
   1               5                  10                  15    
 Ile Gly Ala Asp Ser Ser Glu Glu Tyr Gly Tyr Gly Pro Tyr Gln Pro
              20                  25                  30        
 Val Pro Glu Gln Pro Leu Tyr Pro Gln Pro Tyr Gln Pro Gln Tyr Gln
          35                  40                  45            
 Gln Tyr Thr Phe
      50        



      <210> 1387
      <211> 213
      <212> PRT
      <213> Homo sapiens


      <400> 1387
 Met Ala Pro Ala Phe Leu Leu Leu Leu Leu Trp Pro Gln Gly Cys Val
   1               5                  10                  15    
 Ser Ala Pro Gln Thr Glu Arg Asn Ile Pro Phe Thr His Leu Asp Asn
              20                  25                  30        
 Ile Leu Lys Gly Gly Thr Val Thr Thr Gly Gln Ala Pro Thr Ser Gly
          35                  40                  45            
 Pro Asp Ala Pro Phe Thr Thr Gly Val Met Val Phe Thr Pro Gly Leu
      50                  55                  60                
 Ile Thr Leu Pro Arg Leu Leu Ala Ser Thr Arg Pro Ala Ser Lys Thr
  65                  70                  75                  80
 Gly Tyr Ser Phe Thr Ala Thr Ser Thr Thr Ser Gln Gly Pro Arg Arg
                  85                  90                  95    
 Thr Met Gly Ser Gln Thr Val Thr Ala Ser Pro Ser Asn Ala Arg Asp
             100                 105                 110        
 Ser Ser Ala Gly Pro Glu Ser Ile Ser Thr Lys Ser Gly Asp Leu Ser
         115                 120                 125            
 Thr Arg Ser Pro Thr Thr Gly Leu Cys Leu Thr Ser Arg Ser Leu Leu
     130                 135                 140                
 Asn Arg Leu Pro Ser Met Pro Ser Ile Arg His Gln Asp Val Tyr Ser
 145                 150                 155                 160
 Thr Val Leu Gly Val Val Leu Thr Leu Leu Val Leu Met Leu Ile Met
                 165                 170                 175    
 Val Tyr Gly Phe Trp Lys Lys Arg His Met Ala Ser Tyr Ser Met Cys
             180                 185                 190        
 Ser Asp Pro Ser Thr Arg Asp Pro Pro Gly Arg Pro Glu Pro Tyr Val
         195                 200                 205            
 Glu Val Tyr Leu Ile
     210            



      <210> 1388
      <211> 194
      <212> PRT
      <213> Homo sapiens


      <400> 1388
 Met Leu Arg Leu Ser Glu Arg Asn Met Lys Val Leu Leu Ala Ala Ala
   1               5                  10                  15    
 Leu Ile Ala Gly Ser Val Phe Phe Leu Leu Leu Pro Gly Pro Ser Ala
              20                  25                  30        
 Ala Asp Glu Lys Lys Lys Gly Pro Lys Val Thr Val Lys Val Tyr Phe
          35                  40                  45            
 Asp Leu Arg Ile Gly Asp Glu Asp Val Gly Arg Val Ile Phe Gly Leu
      50                  55                  60                
 Phe Gly Lys Thr Val Pro Lys Thr Val Asp Asn Phe Val Ala Leu Ala
  65                  70                  75                  80
 Thr Gly Glu Lys Gly Phe Gly Tyr Lys Asn Ser Lys Phe His Arg Val
                  85                  90                  95    
 Ile Lys Asp Phe Met Ile Gln Gly Gly Asp Phe Thr Arg Gly Asp Gly
             100                 105                 110        
 Thr Gly Gly Lys Ser Ile Tyr Gly Glu Arg Phe Pro Asp Glu Asn Phe
         115                 120                 125            
 Lys Leu Lys His Tyr Gly Pro Gly Trp Val Ser Met Ala Asn Ala Gly
     130                 135                 140                
 Lys Asp Thr Asn Gly Ser Gln Phe Phe Ile Thr Thr Val Lys Thr Ala
 145                 150                 155                 160
 Trp Leu Asp Gly Lys His Val Val Leu Gly Lys Val Leu Glu Gly Met
                 165                 170                 175    
 Asp Gly Gly Cys Gly Arg Trp Arg Ala Pro Arg Gln Thr Ala Gly Ile
             180                 185                 190        
 Asn Pro
        



      <210> 1389
      <211> 503
      <212> PRT
      <213> Homo sapiens


      <400> 1389
 Met Asp Ala Glu Gly Gly Ala Arg Gly Gly Arg Arg Gly Lys Gly Ser
   1               5                  10                  15    
 Arg Arg Ala Pro Arg Pro Arg Trp Thr Asp Val Pro Ala Arg Cys Ser
              20                  25                  30        
 Arg Arg Arg Ser Glu Ala Ala Leu Ser Ser Gln Arg Asp Leu Phe Ser
          35                  40                  45            
 Ser Pro Phe Phe Leu Asn Ser Ser Ser Arg Glu Arg Leu Val Val Thr
      50                  55                  60                
 Gly Arg Ala Gly Trp Met Gly Met Gly Arg Gly Ala Gly Arg Ser Ala
  65                  70                  75                  80
 Leu Gly Phe Trp Pro Thr Leu Ala Phe Leu Leu Cys Ser Phe Pro Ala
                  85                  90                  95    
 Ala Thr Ser Pro Cys Lys Ile Leu Lys Cys Asn Ser Glu Phe Trp Ser
             100                 105                 110        
 Ala Thr Ser Gly Ser His Ala Pro Ala Ser Asp Asp Thr Pro Glu Phe
         115                 120                 125            
 Cys Ala Ala Leu Arg Ser Tyr Ala Leu Cys Thr Arg Arg Thr Ala Arg
     130                 135                 140                
 Thr Cys Arg Gly Asp Leu Ala Tyr His Ser Ala Val His Gly Ile Glu
 145                 150                 155                 160
 Asp Leu Met Ser Gln His Asn Cys Ser Lys Asp Gly Pro Thr Ser Gln
                 165                 170                 175    
 Pro Arg Leu Arg Thr Leu Pro Pro Ala Gly Asp Ser Gln Glu Arg Ser
             180                 185                 190        
 Asp Ser Pro Glu Ile Cys His Tyr Glu Lys Ser Phe His Lys His Ser
         195                 200                 205            
 Ala Thr Pro Asn Tyr Thr His Cys Gly Leu Phe Gly Asp Pro His Leu
     210                 215                 220                
 Arg Thr Phe Thr Asp Arg Phe Gln Thr Cys Lys Val Gln Gly Ala Trp
 225                 230                 235                 240
 Pro Leu Ile Asp Asn Asn Tyr Leu Asn Val Gln Val Thr Asn Thr Pro
                 245                 250                 255    
 Val Leu Pro Pro Ser Ala Ala Thr Ala Thr Ser Lys Leu Thr Ile Ile
             260                 265                 270        
 Phe Lys Asn Phe Gln Glu Cys Val Asp Gln Lys Val Tyr Gln Ala Glu
         275                 280                 285            
 Met Asp Glu Leu Pro Ala Ala Phe Val Asp Gly Ser Lys Asn Gly Gly
     290                 295                 300                
 Asp Lys His Gly Ala Asn Ser Leu Lys Ile Thr Glu Lys Val Ser Gly
 305                 310                 315                 320
 Gln His Val Glu Ile Gln Ala Lys Tyr Ile Gly Thr Thr Ile Val Val
                 325                 330                 335    
 Arg Gln Val Gly Arg Tyr Leu Thr Phe Ala Val Arg Met Pro Glu Glu
             340                 345                 350        
 Val Val Asn Ala Val Glu Asp Trp Asp Ser Gln Gly Leu Tyr Leu Cys
         355                 360                 365            
 Leu Arg Gly Cys Pro Leu Asn Gln Gln Ile Asp Phe Gln Ala Phe His
     370                 375                 380                
 Thr Asn Ala Glu Gly Thr Gly Ala Arg Arg Leu Ala Ala Ala Ser Pro
 385                 390                 395                 400
 Ala Pro Thr Ala Pro Glu Thr Phe Pro Tyr Glu Thr Ala Val Ala Lys
                 405                 410                 415    
 Cys Lys Glu Lys Leu Pro Val Glu Asp Leu Tyr Tyr Gln Ala Cys Val
             420                 425                 430        
 Phe Asp Leu Leu Thr Thr Gly Asp Val Asn Phe Thr Leu Ala Ala Tyr
         435                 440                 445            
 Tyr Ala Leu Glu Asp Val Lys Met Leu His Ser Asn Lys Asp Lys Leu
     450                 455                 460                
 His Leu Tyr Glu Arg Thr Arg Asp Leu Pro Gly Arg Ala Ala Ala Gly
 465                 470                 475                 480
 Leu Pro Leu Ala Pro Arg Pro Leu Leu Gly Ala Leu Val Pro Leu Leu
                 485                 490                 495    
 Ala Leu Leu Pro Val Phe Cys
             500            



      <210> 1390
      <211> 269
      <212> PRT
      <213> Homo sapiens


      <400> 1390
 Met Pro Leu Asp Ala Thr Trp Asn Ile Thr Val Gln Trp Leu Ala Val
   1               5                  10                  15    
 Asp Ile Ala Cys Arg Thr Leu Met Phe Leu Lys Leu Met Ala Thr Tyr
              20                  25                  30        
 Ser Ala Ala Phe Leu Pro Val Val Ile Gly Leu Asp Arg Gln Ala Ala
          35                  40                  45            
 Val Leu Asn Pro Leu Gly Ser Arg Ser Gly Val Arg Lys Leu Leu Gly
      50                  55                  60                
 Ala Ala Trp Gly Leu Ser Phe Leu Leu Ala Phe Pro Gln Cys Val Thr
  65                  70                  75                  80
 Lys Gly Ser Phe Lys Ala Gln Trp Gln Glu Thr Thr Tyr Asn Leu Phe
                  85                  90                  95    
 Thr Phe Cys Cys Leu Phe Leu Leu Pro Leu Thr Ala Met Ala Ile Cys
             100                 105                 110        
 Tyr Ser Arg Ile Val Leu Ser Val Ser Arg Pro Gln Thr Arg Lys Gly
         115                 120                 125            
 Ser His Ala Pro Ala Gly Glu Phe Ala Leu Pro Arg Ser Phe Asp Asn
     130                 135                 140                
 Cys Pro Arg Val Arg Leu Arg Ala Leu Arg Leu Ala Leu Leu Ile Leu
 145                 150                 155                 160
 Leu Thr Phe Ile Leu Cys Trp Thr Pro Tyr Tyr Leu Leu Gly Met Trp
                 165                 170                 175    
 Tyr Trp Phe Ser Pro Thr Met Leu Thr Glu Val Pro Pro Ser Leu Ser
             180                 185                 190        
 His Ile Leu Phe Leu Leu Gly Leu Leu Asn Ala Pro Leu Asp Pro Leu
         195                 200                 205            
 Leu Tyr Gly Ala Phe Thr Leu Gly Cys Arg Arg Gly His Gln Glu Leu
     210                 215                 220                
 Ser Ile Asp Ser Ser Lys Glu Gly Ser Gly Arg Met Leu Gln Glu Glu
 225                 230                 235                 240
 Ile His Ala Phe Arg Gln Leu Glu Val Gln Lys Thr Val Thr Ser Arg
                 245                 250                 255    
 Arg Ala Gly Glu Thr Lys Gly Ile Ser Ile Thr Ser Ile
             260                 265                



      <210> 1391
      <211> 466
      <212> PRT
      <213> Homo sapiens


      <400> 1391
 Met Ala Glu Ala Glu Gly Val Pro Thr Thr Pro Gly Pro Ala Ser Gly
   1               5                  10                  15    
 Ser Thr Phe Arg Gly Arg Arg Asp Val Ser Gly Ser Trp Glu Arg Asp
              20                  25                  30        
 Gln Gln Val Glu Ala Ala Gln Arg Ala Leu Val Glu Val Leu Gly Pro
          35                  40                  45            
 Tyr Glu Pro Leu Leu Ser Arg Val Gln Ala Ala Leu Val Trp Glu Arg
      50                  55                  60                
 Pro Ala Arg Ser Ala Leu Trp Cys Leu Gly Leu Asn Ala Ala Phe Trp
  65                  70                  75                  80
 Phe Phe Ala Leu Thr Ser Leu Arg Leu Val Phe Leu Leu Ala Phe Gly
                  85                  90                  95    
 Leu Met Ile Ile Val Cys Ile Asp Gln Trp Lys Asn Lys Ile Trp Pro
             100                 105                 110        
 Glu Ile Lys Val Pro Arg Pro Asp Ala Leu Asp Asn Glu Ser Trp Gly
         115                 120                 125            
 Phe Val His Pro Arg Leu Leu Ser Val Pro Glu Leu Cys His His Val
     130                 135                 140                
 Ala Glu Val Trp Val Ser Gly Thr Ile Phe Ile Arg Asn Val Leu Leu
 145                 150                 155                 160
 Phe Lys Lys Gln Asn Pro Gly Lys Phe Cys Leu Leu Ser Cys Gly Ile
                 165                 170                 175    
 Leu Thr Phe Leu Ala Val Leu Gly Arg Tyr Val Pro Gly Leu Leu Leu
             180                 185                 190        
 Ser Tyr Leu Met Leu Val Thr Val Met Met Trp Pro Leu Ala Val Tyr
         195                 200                 205            
 His Arg Leu Trp Asp Arg Ala Tyr Val Arg Leu Lys Pro Ala Leu Gln
     210                 215                 220                
 Arg Leu Asp Phe Ser Val Arg Gly Tyr Met Met Ser Lys Gln Arg Glu
 225                 230                 235                 240
 Arg Gln Leu Arg Arg Arg Ala Leu His Pro Glu Arg Ala Met Asp Asn
                 245                 250                 255    
 His Ser Asp Ser Glu Glu Glu Leu Ala Ala Phe Cys Pro Gln Leu Asp
             260                 265                 270        
 Asp Ser Thr Val Ala Arg Glu Leu Ala Ile Thr Asp Ser Glu His Ser
         275                 280                 285            
 Asp Ala Glu Val Ser Cys Thr Asp Asn Gly Thr Phe Asn Leu Ser Arg
     290                 295                 300                
 Gly Gln Thr Pro Leu Thr Glu Gly Ser Glu Asp Leu Asp Gly His Ser
 305                 310                 315                 320
 Asp Pro Glu Glu Ser Phe Ala Arg Asp Leu Pro Asp Phe Pro Ser Ile
                 325                 330                 335    
 Asn Met Asp Pro Ala Gly Leu Asp Asp Glu Asp Asp Thr Ser Ile Gly
             340                 345                 350        
 Met Pro Ser Leu Met Tyr Arg Ser Pro Pro Gly Ala Glu Glu Pro Gln
         355                 360                 365            
 Ala Pro Pro Ala Ser Arg Asp Glu Ala Ala Leu Pro Glu Leu Leu Leu
     370                 375                 380                
 Gly Ala Leu Pro Val Gly Ser Asn Leu Thr Ser Asn Leu Ala Ser Leu
 385                 390                 395                 400
 Val Ser Gln Gly Met Ile Gln Leu Ala Leu Ser Gly Ala Ser Gln Pro
                 405                 410                 415    
 Gly Pro Ser Gly Ala Pro Ala Gln Arg Ala Thr Arg Gly Phe Leu Arg
             420                 425                 430        
 Ser Pro Ser Ser Asp Leu Asp Thr Asp Ala Glu Gly Asp Asp Phe Glu
         435                 440                 445            
 Leu Leu Asp Gln Ser Glu Leu Ser Gln Leu Asp Pro Ala Ser Ser Arg
     450                 455                 460                
 Ser His
 465    



      <210> 1392
      <211> 312
      <212> PRT
      <213> Homo sapiens


      <400> 1392
 Met Met Cys Leu Glu Cys Ala Ser Ala Ala Ala Gly Gly Ala Glu Glu
   1               5                  10                  15    
 Glu Glu Ala Asp Ala Glu Arg Arg Arg Arg Arg Arg Gly Ala Gln Arg
              20                  25                  30        
 Gly Ala Gly Gly Ser Gly Cys Cys Gly Ala Arg Gly Ala Gly Gly Ala
          35                  40                  45            
 Gly Val Ser Ala Ala Gly Asp Glu Val Gln Thr Leu Ser Gly Ser Val
      50                  55                  60                
 Arg Arg Ala Pro Thr Gly Pro Pro Gly Thr Pro Gly Thr Pro Gly Cys
  65                  70                  75                  80
 Ala Ala Thr Ala Lys Gly Pro Gly Ala Gln Gln Pro Lys Pro Thr Ser
                  85                  90                  95    
 Leu Gly Arg Gly Arg Gly Ala Ala Ala Ala Ile Leu Ser Leu Gly Asn
             100                 105                 110        
 Val Leu Asn Tyr Leu Asp Arg Tyr Thr Val Ala Gly Val Leu Leu Asp
         115                 120                 125            
 Ile Gln Gln His Phe Gly Val Lys Asp Arg Gly Ala Gly Leu Leu Gln
     130                 135                 140                
 Ser Val Phe Ile Cys Ser Phe Met Val Ala Ala Pro Ile Phe Gly Tyr
 145                 150                 155                 160
 Leu Gly Asp Arg Phe Asn Arg Lys Val Ile Leu Ser Cys Gly Ile Phe
                 165                 170                 175    
 Phe Trp Ser Ala Val Thr Phe Ser Ser Ser Phe Ile Pro Gln Gln Tyr
             180                 185                 190        
 Phe Trp Leu Leu Val Leu Ser Arg Gly Leu Val Gly Ile Gly Glu Ala
         195                 200                 205            
 Ser Tyr Ser Thr Ile Ala Pro Thr Ile Ile Gly Asp Leu Phe Thr Lys
     210                 215                 220                
 Asn Thr Arg Thr Leu Met Leu Ser Val Phe Tyr Phe Ala Ile Pro Leu
 225                 230                 235                 240
 Gly Ser Gly Leu Gly Tyr Ile Thr Gly Ser Ser Val Lys Gln Ala Ala
                 245                 250                 255    
 Gly Asp Trp His Trp Ala Leu Arg Val Ser Pro Val Leu Gly Met Ile
             260                 265                 270        
 Thr Gly Thr Leu Ile Leu Ile Leu Val Pro Ala Thr Lys Arg Gly His
         275                 280                 285            
 Ala Asp Gln Leu Gly Asp Gln Leu Lys Ala Arg Thr Ser Trp Leu Arg
     290                 295                 300                
 Asp Met Lys Ala Leu Ile Arg Lys
 305                 310        



      <210> 1393
      <211> 360
      <212> PRT
      <213> Homo sapiens


      <400> 1393
 Met Phe Ile Asp Ser His Gln Ile Arg Asn Leu Thr Asn Leu Phe Ser
   1               5                  10                  15    
 Ala Gly Val Arg Glu Lys Gln Tyr Leu Phe Ser Leu Glu Thr Gly Ile
              20                  25                  30        
 Pro Pro Val Asn Leu Gln Ser Gly Asp Lys Trp Leu Arg Asn Val Glu
          35                  40                  45            
 Met Arg Cys Leu Trp Ala Gly Ser Cys Met Asp Ser Pro Ser Asn Ala
      50                  55                  60                
 Thr Val Pro Cys Gly Phe Leu Leu Gln Gly Phe Ser Glu Phe Pro His
  65                  70                  75                  80
 Leu Arg Pro Val Leu Phe Leu Leu Leu Leu Gly Val His Leu Ala Thr
                  85                  90                  95    
 Leu Gly Gly Asn Leu Leu Ile Leu Val Ala Val Ala Ser Met Pro Ser
             100                 105                 110        
 Arg Gln Pro Met Leu Leu Phe Leu Cys Gln Leu Ser Ala Ile Glu Leu
         115                 120                 125            
 Cys Tyr Thr Leu Val Val Val Pro Arg Ser Leu Met Gln Met Phe Val
     130                 135                 140                
 Ala Leu Gly Gly Ala Glu Cys Phe Leu Leu Ala Ala Met Ala Tyr Asp
 145                 150                 155                 160
 Arg Tyr Val Ala Ile Cys His Pro Leu Arg Tyr Ala Ala Val Val Thr
                 165                 170                 175    
 Pro Gly Leu Cys Ala Arg Leu Ala Leu Ala Cys Cys Leu Arg Gly Leu
             180                 185                 190        
 Ala Val Ser Val Gly Leu Thr Val Ala Ile Phe His Leu Pro Phe Cys
         195                 200                 205            
 Gly Ser Arg Leu Leu Leu His Phe Phe Cys Asp Ile Thr Ala Leu Leu
     210                 215                 220                
 His Leu Ala Cys Thr Arg Ser Tyr Ala Asp Glu Leu Pro Leu Leu Gly
 225                 230                 235                 240
 Ala Cys Leu Val Leu Leu Leu Leu Pro Ser Val Leu Ile Leu Ala Ser
                 245                 250                 255    
 Tyr Gly Ala Ile Ala Ala Ala Leu Arg Arg Leu Arg Cys Pro Lys Gly
             260                 265                 270        
 Arg Gly Lys Ala Ala Ser Thr Cys Ala Leu His Leu Ala Val Thr Phe
         275                 280                 285            
 Leu His Tyr Gly Cys Ala Thr Phe Met Tyr Val Arg Pro Arg Ala Ser
     290                 295                 300                
 Tyr Ser Pro Arg Leu Asp Arg Thr Leu Ala Leu Val Tyr Thr Asn Val
 305                 310                 315                 320
 Thr Pro Leu Leu Cys Pro Leu Ile Tyr Ser Leu Arg Asn Arg Glu Ile
                 325                 330                 335    
 Thr Ala Ala Leu Ser Arg Val Leu Gly Arg Arg Arg Pro Gly Gln Ala
             340                 345                 350        
 Pro Gly Gly Asp Leu Arg Glu Leu
         355                 360



      <210> 1394
      <211> 71
      <212> PRT
      <213> Homo sapiens


      <400> 1394
 Met Ser Ser Ile Leu Met Ser Leu Ala Ile Arg Ile Gly Leu Leu Ile
   1               5                  10                  15    
 Leu Val Gly Cys Cys Val Ile Pro Cys Ala Leu Gly Leu Ile Gln Lys
              20                  25                  30        
 Leu Ile Glu Thr Ala Leu Pro Lys Thr Ser Leu Asn Pro Pro Pro Pro
          35                  40                  45            
 Arg Ser Ser Glu Leu Phe Leu Leu Glu Asp Pro Ser Arg Ile Thr Glu
      50                  55                  60                
 Pro Asn Tyr Val Lys Arg Val
  65                  70    



      <210> 1395
      <211> 151
      <212> PRT
      <213> Homo sapiens


      <400> 1395
 Met Glu Tyr Val Leu Glu Val Lys Asn Ser Pro Arg His Leu Leu Lys
   1               5                  10                  15    
 Gln Phe Thr Val Cys Asp Val Pro Leu Tyr Asp Ile Cys Asp Tyr Asn
              20                  25                  30        
 Val Ser Arg Asp Arg Cys Gln Glu Leu Gly Cys Cys Phe Tyr Glu Gly
          35                  40                  45            
 Val Cys Tyr Lys Lys Ala Val Pro Ile Tyr Ile His Val Phe Ser Ala
      50                  55                  60                
 Leu Ile Val Ile Ile Ala Gly Ala Phe Val Ile Thr Ile Ile Tyr Arg
  65                  70                  75                  80
 Val Ile Gln Glu Ser Arg Lys Glu Lys Ala Ile Pro Val Asp Val Ala
                  85                  90                  95    
 Leu Pro Gln Lys Ser Ser Glu Lys Ala Glu Leu Ala Ser Ser Ser Ser
             100                 105                 110        
 Lys Leu Gly Leu Lys Pro Ala Ser Pro Gly Pro Pro Ser Ala Gly Pro
         115                 120                 125            
 Ser Met Lys Ser Asp Glu Asp Lys Asp Asp Val Thr Gly Thr Ile Thr
     130                 135                 140                
 Glu Ala Glu Glu Thr Glu Asp
 145                 150    



      <210> 1396
      <211> 149
      <212> PRT
      <213> Homo sapiens


      <400> 1396
 Met Val Thr Val Thr Ile Ala Asn Trp Arg Thr Leu Glu Ile Ser Ala
   1               5                  10                  15    
 Ala Ala Pro Val Leu Leu Gly Ile Leu Phe Ser Leu Leu Cys Leu Lys
              20                  25                  30        
 Ala Asn Met Lys Gln His Asp Leu Phe Gln Leu Leu Ile Pro Met Cys
          35                  40                  45            
 Ser Phe Ile Leu Thr Leu Gly Phe Asp Ala Lys Asp Ile His Pro Gly
      50                  55                  60                
 Arg Val Thr Gly Met Trp Leu Ser Val Trp Leu Leu Leu Ala Gln Thr
  65                  70                  75                  80
 Leu Met Gly Gly Gly Ala Gln Arg Trp Ala Gly Val Arg Thr Arg Ile
                  85                  90                  95    
 Lys Ile Glu Ala Leu Ile Phe Tyr Asn Ile Ile Gly Ser Phe Glu Ala
             100                 105                 110        
 Gln Leu Glu Gln Leu Ser Thr Val Ile Leu Ala Gly Thr Asn Asn Leu
         115                 120                 125            
 Leu Gln Ile Pro Thr Ser Val Phe Met Lys Gly Lys Glu Leu Thr Gly
     130                 135                 140                
 Leu Gln Thr Ala Pro
 145                



      <210> 1397
      <211> 1339
      <212> PRT
      <213> Homo sapiens


      <400> 1397
 Met Ala Arg Gly Asp Ala Gly Arg Gly Arg Gly Leu Leu Ala Leu Thr
   1               5                  10                  15    
 Phe Cys Leu Leu Ala Ala Arg Gly Thr Asp Gln Gly Ser Val Asp Glu
              20                  25                  30        
 Val Ser Arg Ala Ser Ser Ser Pro Gln Pro Ser Ala Glu Trp Val Arg
          35                  40                  45            
 Ala Thr Arg Pro Phe Pro Lys Asn Ser Leu Lys Asn Gly Thr His Ala
      50                  55                  60                
 Arg Pro Pro Leu Ile Pro Arg Asn Ser Ile Glu Leu Ala Leu Glu Leu
  65                  70                  75                  80
 Ser Ser Glu Ser Pro Phe Cys Leu Gly Ser Asn Trp Pro His Lys Ile
                  85                  90                  95    
 Gln Phe Ile Leu Pro Cys Met Gly Asp Ser Gly Ala Glu Ala Val Gly
             100                 105                 110        
 Gly Gly Gly Thr Tyr Thr Asp Gly Pro Val Leu Leu Leu Tyr Ala Gly
         115                 120                 125            
 Glu Leu Leu Leu Pro Gln Glu Thr Thr Val Glu Leu Ser Cys Gly Val
     130                 135                 140                
 Gly Pro Leu Gln Val Ile Leu Gly Pro Glu Gln Ala Ala Val Leu Asn
 145                 150                 155                 160
 Cys Ser Leu Gly Ala Ala Ala Ala Gly Pro Pro Thr Arg Val Thr Trp
                 165                 170                 175    
 Ser Lys Asp Gly Asp Thr Leu Leu Glu His Asp His Leu His Leu Leu
             180                 185                 190        
 Pro Asn Gly Ser Leu Trp Leu Ser Gln Pro Leu Ala Pro Asn Gly Ser
         195                 200                 205            
 Asp Glu Ser Val Pro Glu Ala Val Gly Val Ile Glu Gly Asn Tyr Ser
     210                 215                 220                
 Cys Leu Ala His Gly Pro Leu Gly Val Leu Ala Ser Gln Thr Ala Val
 225                 230                 235                 240
 Val Lys Leu Ala Thr Leu Ala Asp Phe Ser Leu His Pro Glu Ser Gln
                 245                 250                 255    
 Thr Val Glu Glu Asn Gly Thr Ala Arg Phe Glu Cys His Ile Glu Gly
             260                 265                 270        
 Leu Pro Ala Pro Ile Ile Thr Trp Glu Lys Asp Gln Val Thr Leu Pro
         275                 280                 285            
 Glu Glu Pro Arg Leu Ile Val Leu Pro Asn Gly Val Leu Gln Ile Leu
     290                 295                 300                
 Asp Val Gln Glu Ser Asp Ala Gly Pro Tyr Arg Cys Val Ala Thr Asn
 305                 310                 315                 320
 Ser Ala Arg Gln His Phe Ser Gln Glu Ala Leu Leu Ser Val Ala His
                 325                 330                 335    
 Arg Gly Ser Leu Ala Ser Thr Arg Gly Gln Asp Val Val Ile Val Ala
             340                 345                 350        
 Ala Pro Glu Asn Thr Thr Val Val Ser Gly Gln Ser Val Val Met Glu
         355                 360                 365            
 Cys Val Ala Ser Ala Asp Pro Thr Pro Phe Val Ser Trp Val Arg Gln
     370                 375                 380                
 Asp Gly Lys Pro Ile Ser Thr Asp Val Ile Val Leu Gly Arg Thr Asn
 385                 390                 395                 400
 Leu Leu Ile Ala Asn Ala Gln Pro Trp His Ser Gly Val Tyr Val Cys
                 405                 410                 415    
 Arg Ala Asn Lys Pro Arg Thr Arg Asp Phe Ala Thr Ala Ala Ala Glu
             420                 425                 430        
 Leu Arg Val Leu Ala Ala Pro Ala Ile Thr Gln Ala Pro Glu Ala Leu
         435                 440                 445            
 Ser Arg Thr Arg Ala Ser Thr Ala Arg Phe Val Cys Arg Ala Ser Gly
     450                 455                 460                
 Glu Pro Arg Pro Ala Leu Arg Trp Leu His Asn Gly Ala Pro Leu Arg
 465                 470                 475                 480
 Pro Asn Gly Arg Val Lys Val Gln Gly Gly Gly Gly Ser Leu Val Ile
                 485                 490                 495    
 Thr Gln Ile Gly Leu Gln Asp Ala Gly Tyr Tyr Gln Cys Val Ala Glu
             500                 505                 510        
 Asn Ser Ala Gly Met Ala Cys Ala Ala Ala Ser Leu Ala Val Val Val
         515                 520                 525            
 Arg Glu Gly Leu Pro Ser Ala Pro Thr Arg Val Thr Ala Thr Pro Leu
     530                 535                 540                
 Ser Ser Ser Ala Val Leu Val Ala Trp Glu Arg Pro Glu Met His Ser
 545                 550                 555                 560
 Glu Gln Ile Ile Gly Phe Ser Leu His Tyr Gln Lys Ala Arg Gly Met
                 565                 570                 575    
 Asp Asn Val Glu Tyr Gln Phe Ala Val Asn Asn Asp Thr Thr Glu Leu
             580                 585                 590        
 Gln Val Arg Asp Leu Glu Pro Asn Thr Asp Tyr Glu Phe Tyr Val Val
         595                 600                 605            
 Ala Tyr Ser Gln Leu Gly Ala Ser Arg Thr Ser Thr Pro Ala Leu Val
     610                 615                 620                
 His Thr Leu Asp Asp Val Pro Ser Ala Ala Pro Gln Leu Ser Leu Ser
 625                 630                 635                 640
 Ser Pro Asn Pro Ser Asp Ile Arg Val Ala Trp Leu Pro Leu Pro Pro
                 645                 650                 655    
 Ser Leu Ser Asn Gly Gln Val Val Lys Tyr Lys Ile Glu Tyr Gly Leu
             660                 665                 670        
 Gly Lys Glu Asp Gln Ile Phe Ser Thr Glu Val Arg Gly Asn Glu Thr
         675                 680                 685            
 Gln Leu Met Leu Asn Ser Leu Gln Pro Asn Lys Val Tyr Arg Val Arg
     690                 695                 700                
 Ile Ser Ala Gly Thr Ala Ala Gly Phe Gly Ala Pro Ser Gln Trp Met
 705                 710                 715                 720
 His His Arg Thr Pro Ser Met His Asn Gln Ser His Val Pro Phe Ala
                 725                 730                 735    
 Pro Ala Glu Leu Lys Val Gln Ala Lys Met Glu Ser Leu Val Val Ser
             740                 745                 750        
 Trp Gln Pro Pro Pro His Pro Thr Gln Ile Ser Gly Tyr Lys Leu Tyr
         755                 760                 765            
 Trp Arg Glu Val Gly Ala Glu Glu Glu Ala Asn Gly Asp Arg Leu Pro
     770                 775                 780                
 Gly Gly Arg Gly Asp Gln Ala Trp Asp Val Gly Pro Val Arg Leu Lys
 785                 790                 795                 800
 Lys Lys Val Lys Gln Tyr Glu Leu Thr Gln Leu Val Pro Gly Arg Leu
                 805                 810                 815    
 Tyr Glu Val Lys Leu Val Ala Phe Asn Lys His Glu Asp Gly Tyr Ala
             820                 825                 830        
 Ala Val Trp Lys Gly Lys Thr Glu Lys Ala Pro Ala Pro Asp Met Pro
         835                 840                 845            
 Ile Gln Arg Gly Pro Pro Leu Pro Pro Ala His Val His Ala Glu Ser
     850                 855                 860                
 Asn Ser Ser Thr Ser Ile Trp Leu Arg Trp Lys Lys Pro Asp Phe Thr
 865                 870                 875                 880
 Thr Val Lys Ile Val Asn Tyr Thr Val Arg Phe Ser Pro Trp Gly Leu
                 885                 890                 895    
 Arg Asn Ala Ser Leu Val Thr Tyr Tyr Thr Ser Ser Gly Glu Asp Ile
             900                 905                 910        
 Leu Ile Gly Gly Leu Lys Pro Phe Thr Lys Tyr Glu Phe Ala Val Gln
         915                 920                 925            
 Ser His Gly Val Asp Met Asp Gly Pro Phe Gly Ser Val Val Glu Arg
     930                 935                 940                
 Ser Thr Leu Pro Asp Arg Pro Ser Thr Pro Pro Ser Asp Leu Arg Leu
 945                 950                 955                 960
 Ser Pro Leu Thr Pro Ser Thr Val Arg Leu His Trp Cys Pro Pro Thr
                 965                 970                 975    
 Glu Pro Asn Gly Glu Ile Val Glu Tyr Leu Ile Leu Tyr Ser Ser Asn
             980                 985                 990        
 His Thr Gln Pro Glu His Gln Trp Thr Leu Leu Thr Thr Gln Gly Asn
         995                1000                1005            
 Ile Phe Ser Ala Glu Val His Gly Leu Glu Ser Asp Thr Arg Tyr Phe
    1010                1015                1020                
 Phe Lys Met Gly Ala Arg Thr Glu Val Gly Pro Gly Pro Phe Ser Arg
1025                1030                1035                1040
 Leu Gln Asp Val Ile Thr Leu Gln Glu Lys Leu Ser Asp Ser Leu Asp
                1045                1050                1055    
 Met His Ser Val Thr Gly Ile Ile Val Gly Val Cys Leu Gly Leu Leu
            1060                1065                1070        
 Cys Leu Leu Ala Cys Met Cys Ala Gly Leu Arg Arg Ser Pro His Arg
        1075                1080                1085            
 Glu Ser Leu Pro Gly Leu Ser Ser Thr Ala Thr Pro Gly Asn Pro Ala
    1090                1095                1100                
 Leu Tyr Ser Arg Ala Arg Leu Gly Pro Pro Ser Pro Pro Ala Ala His
1105                1110                1115                1120
 Glu Leu Glu Ser Leu Val His Pro His Pro Gln Asp Trp Ser Pro Pro
                1125                1130                1135    
 Pro Ser Asp Val Glu Asp Arg Ala Glu Val His Ser Leu Met Gly Gly
            1140                1145                1150        
 Gly Val Ser Glu Gly Arg Ser His Ser Lys Arg Lys Ile Ser Trp Ala
        1155                1160                1165            
 Gln Pro Ser Gly Leu Ser Trp Ala Gly Ser Trp Ala Gly Cys Glu Leu
    1170                1175                1180                
 Pro Gln Ala Gly Pro Arg Pro Ala Leu Thr Arg Ala Leu Leu Pro Pro
1185                1190                1195                1200
 Ala Gly Thr Gly Gln Thr Leu Leu Leu Gln Ala Leu Val Tyr Asp Ala
                1205                1210                1215    
 Ile Lys Val Ser Val Leu Glu Gly Arg Gly Arg Lys Gly Gly Lys Gly
            1220                1225                1230        
 Leu Gly His Ser Ala Glu Leu Ala Phe Ala Val Glu Pro Ser Asp Asp
        1235                1240                1245            
 Val Ala Val Pro Gly Gln Pro Ile Val Leu Asp Cys Arg Val Glu Gly
    1250                1255                1260                
 Thr Pro Pro Val Arg Ile Thr Trp Arg Lys Asn Gly Val Glu Leu Pro
1265                1270                1275                1280
 Glu Ser Thr His Ser Thr Leu Leu Ala Asn Gly Ser Leu Met Ile Arg
                1285                1290                1295    
 His Phe Arg Leu Glu Pro Gly Gly Ser Pro Ser Asp Glu Gly Asp Tyr
            1300                1305                1310        
 Glu Cys Val Ala Gln Asn Arg Phe Gly Leu Val Val Ser Arg Lys Ala
        1315                1320                1325            
 Arg Ile Gln Ala Ala Lys Glu Lys Thr Glu Pro
    1330                1335                



      <210> 1398
      <211> 415
      <212> PRT
      <213> Homo sapiens


      <400> 1398
 Met Ser Asn Val Ser Gly Ile Leu Glu Thr Ala Gly Val Pro Leu Val
   1               5                  10                  15    
 Ser Val Asn Trp Pro Gln Pro Ser Pro Pro Pro Ala Val Pro Ala Gly
              20                  25                  30        
 Pro Gln Met Asp His Met Gly Asn Ser Ser Gln Gly Ala Pro Trp Leu
          35                  40                  45            
 Phe Leu Thr Ser Ala Leu Ala Arg Gly Val Ser Gly Ile Phe Val Trp
      50                  55                  60                
 Thr Ala Leu Val Leu Thr Cys His Gln Ile Tyr Leu His Leu Arg Ser
  65                  70                  75                  80
 Tyr Thr Val Pro Gln Glu Gln Arg Tyr Ile Ile Arg Leu Leu Leu Ile
                  85                  90                  95    
 Val Pro Ile Tyr Ala Phe Asp Ser Trp Leu Ser Leu Leu Leu Leu Gly
             100                 105                 110        
 Asp His Gln Tyr Tyr Val Tyr Phe Asp Ser Val Arg Asp Cys Tyr Glu
         115                 120                 125            
 Ala Phe Val Ile Tyr Ser Phe Leu Ser Leu Cys Phe Gln Tyr Leu Gly
     130                 135                 140                
 Gly Glu Gly Ala Ile Met Ala Glu Ile Arg Gly Lys Pro Ile Lys Ser
 145                 150                 155                 160
 Ser Cys Leu Tyr Gly Thr Cys Cys Leu Arg Gly Met Thr Tyr Ser Ile
                 165                 170                 175    
 Gly Phe Leu Arg Phe Cys Lys Gln Ala Thr Leu Gln Phe Cys Leu Val
             180                 185                 190        
 Lys Pro Val Met Ala Val Thr Thr Ile Ile Leu Gln Ala Phe Gly Lys
         195                 200                 205            
 Tyr His Asp Gly Asp Phe Asn Val Arg Ser Gly Tyr Leu Tyr Val Thr
     210                 215                 220                
 Leu Ile Tyr Asn Ala Ser Val Ser Leu Ala Leu Tyr Ala Leu Phe Leu
 225                 230                 235                 240
 Phe Tyr Phe Thr Thr Arg Glu Leu Leu Arg Pro Phe Gln Pro Val Leu
                 245                 250                 255    
 Lys Phe Leu Thr Ile Lys Ala Val Ile Phe Leu Ser Phe Trp Gln Gly
             260                 265                 270        
 Leu Leu Leu Ala Ile Leu Glu Arg Cys Gly Val Ile Pro Glu Val Glu
         275                 280                 285            
 Thr Ser Gly Gly Asn Lys Leu Gly Ala Gly Thr Leu Ala Ala Gly Tyr
     290                 295                 300                
 Gln Asn Phe Ile Ile Cys Val Glu Met Leu Phe Ala Ser Val Ala Leu
 305                 310                 315                 320
 Arg Tyr Ala Phe Pro Cys Gln Val Tyr Ala Glu Lys Lys Glu Asn Ser
                 325                 330                 335    
 Pro Ala Pro Pro Ala Pro Met Gln Ser Ile Ser Ser Gly Ile Arg Glu
             340                 345                 350        
 Thr Val Ser Pro Gln Asp Ile Val Gln Asp Ala Ile His Asn Phe Ser
         355                 360                 365            
 Pro Ala Tyr Gln His Tyr Thr Gln Gln Ala Thr His Glu Ala Pro Thr
     370                 375                 380                
 Cys Leu His Thr Pro Ala Thr Gly Glu Pro Trp Pro Gly Ala Gln Pro
 385                 390                 395                 400
 Gly Glu Arg Val Pro Gly Met Gly His Arg Thr Ser Gly His Leu
                 405                 410                 415



      <210> 1399
      <211> 120
      <212> PRT
      <213> Homo sapiens


      <400> 1399
 Met Thr Pro Met Leu Val Thr Asp Thr Glu Ala Phe Trp Gln Pro Gln
   1               5                  10                  15    
 Pro Trp Phe Val Val Val Leu Thr Ala Thr Gly Ala Leu Leu Leu Leu
              20                  25                  30        
 Ala Leu Gly Trp Leu Leu Gly Arg Leu Leu Gln Gly Leu Ala Gln Leu
          35                  40                  45            
 Leu Gln Ala Pro Ser Lys Pro Ala Gln Ala Leu Leu Leu Asn Ser Ile
      50                  55                  60                
 Gln Gly Thr Glu Gly Ser Ile Glu Gly Phe Leu Glu Ala Pro Lys Met
  65                  70                  75                  80
 Glu Met Ser Gln Ala Pro Ser Ser Val Met Ser Leu Gln His Phe Asp
                  85                  90                  95    
 Gly Arg Ala Gln Asp Ser Arg Thr Gly Arg Asp Tyr Leu Phe Asn Thr
             100                 105                 110        
 His Thr Gly Ala Arg Arg Trp Leu
         115                 120



      <210> 1400
      <211> 49
      <212> PRT
      <213> Homo sapiens


      <400> 1400
 Met Pro Val Cys Val Leu Gln Leu Asn Asn Cys Leu Gly Ala Tyr Cys
   1               5                  10                  15    
 Val Ile Ser Ser Phe Phe Thr Asn Thr Phe Leu Leu Leu Asn Ala Val
              20                  25                  30        
 Ile Asn Phe Leu Tyr Leu Gly Tyr Leu Gly Phe Ser Glu Ser Pro His
          35                  40                  45            
 Lys
    



      <210> 1401
      <211> 77
      <212> PRT
      <213> Homo sapiens


      <400> 1401
 Met Trp Val Tyr Ala Cys Val Phe Met Arg Val Phe Met Cys Val His
   1               5                  10                  15    
 Gly Cys Val Ser Val Tyr Met His Leu His Ile His Gly Gly Val Cys
              20                  25                  30        
 Ile His Met Arg Ile His Ala Cys Ala Trp Leu Cys Pro Cys Val Cys
          35                  40                  45            
 Ala Leu Thr Cys Thr Cys Gly Cys Met Cys Ala Cys Val Phe Leu Cys
      50                  55                  60                
 Val Phe Val Gly Trp Val Leu Arg Val His Val Val Trp
  65                  70                  75        



      <210> 1402
      <211> 103
      <212> PRT
      <213> Homo sapiens


      <400> 1402
 Met Phe Asn Leu Ser Phe Phe Thr Leu Tyr Gly Leu Cys Met Leu Lys
   1               5                  10                  15    
 Leu His Ser Ala Ser Ser Trp Phe Thr Leu Leu Leu Leu Ile Ser Leu
              20                  25                  30        
 Phe Leu Ser Val Val Tyr Cys Gln Ser Thr Asn Tyr Ile Leu Leu Leu
          35                  40                  45            
 Phe Leu Phe Tyr Thr Gly Asn Ile Tyr Leu Asp Leu His Arg Cys Leu
      50                  55                  60                
 Pro Phe Ser Leu Leu Ser Val Leu Ser Asn Thr Ser Phe Arg Asn Ser
  65                  70                  75                  80
 Phe Asn Leu Val Ser Cys Trp Arg Met Phe Ser Phe His Leu Ser Ile
                  85                  90                  95    
 Lys Cys Leu Ser Leu Phe Ser
             100            



      <210> 1403
      <211> 75
      <212> PRT
      <213> Homo sapiens


      <400> 1403
 Met Thr Gln Val His Gln Arg Val Leu Val Cys Thr Val Ala Asp Leu
   1               5                  10                  15    
 Gly Phe Ile Ser Cys Leu Asp Leu Leu His Tyr Gln Gln Ser Glu Ser
              20                  25                  30        
 Leu Arg Ser Pro Gly Gln Glu Ile Ser Glu Ala Ser Leu Ser Phe Gly
          35                  40                  45            
 Pro Ser Ser Pro Pro Arg Ala Phe Val Ser Gly Ser Phe Gly Phe Phe
      50                  55                  60                
 Ile Phe Leu Thr Ser Leu Ser Val Met Leu Leu
  65                  70                  75



      <210> 1404
      <211> 271
      <212> PRT
      <213> Homo sapiens


      <400> 1404
 Met Ile Pro Lys Leu Leu Ser Leu Leu Cys Phe Arg Leu Cys Val Gly
   1               5                  10                  15    
 Gln Gly Asp Thr Arg Gly Asp Gly Ser Leu Pro Lys Pro Ser Leu Ser
              20                  25                  30        
 Ala Trp Pro Ser Ser Val Val Pro Ala Asn Ser Asn Val Thr Leu Arg
          35                  40                  45            
 Cys Trp Thr Pro Ala Arg Gly Val Ser Phe Val Leu Arg Lys Gly Gly
      50                  55                  60                
 Ile Ile Leu Glu Ser Pro Lys Pro Leu Asp Ser Thr Glu Gly Ala Ala
  65                  70                  75                  80
 Glu Phe His Leu Asn Asn Leu Lys Val Arg Asn Ala Gly Glu Tyr Thr
                  85                  90                  95    
 Cys Glu Tyr Tyr Arg Lys Ala Ser Pro His Ile Leu Ser Gln Arg Ser
             100                 105                 110        
 Asp Val Leu Leu Leu Leu Val Thr Gly His Leu Ser Lys Pro Phe Leu
         115                 120                 125            
 Arg Thr Tyr Gln Arg Gly Thr Val Thr Ala Gly Gly Arg Val Thr Leu
     130                 135                 140                
 Gln Cys Gln Lys Arg Asp Gln Leu Phe Val Pro Ile Met Phe Ala Leu
 145                 150                 155                 160
 Leu Lys Ala Gly Thr Pro Ser Pro Ile Gln Leu Gln Ser Pro Ala Gly
                 165                 170                 175    
 Lys Glu Ile Asp Phe Ser Leu Val Asp Val Thr Ala Gly Asp Ala Gly
             180                 185                 190        
 Asn Tyr Ser Cys Met Tyr Tyr Gln Thr Lys Ser Pro Phe Trp Ala Ser
         195                 200                 205            
 Glu Pro Ser Asp Gln Leu Glu Ile Leu Val Thr Val Pro Pro Gly Thr
     210                 215                 220                
 Thr Ser Ser Asn Tyr Ser Leu Gly Asn Phe Val Arg Leu Gly Leu Ala
 225                 230                 235                 240
 Ala Val Ile Val Val Ile Met Gly Ala Phe Leu Val Glu Ala Trp Tyr
                 245                 250                 255    
 Ser Arg Asn Val Ser Pro Gly Glu Ser Glu Ala Phe Lys Pro Glu
             260                 265                 270    



      <210> 1405
      <211> 108
      <212> PRT
      <213> Homo sapiens


      <400> 1405
 Met Ile Ser Trp Val Leu Leu Phe Ser Leu Leu Cys Pro Ser Val Asn
   1               5                  10                  15    
 Tyr Leu Leu Ala Phe Glu Pro Thr Tyr Val Ala Phe Tyr Tyr Gly Asn
              20                  25                  30        
 Asn Asn Ile Glu Ala Met Tyr Val Phe Thr Tyr Pro Cys Leu Arg Leu
          35                  40                  45            
 Leu Glu Thr Gly Asp Gln Ser Asn Asp Ile His Glu Leu Ala Tyr Met
      50                  55                  60                
 Arg Ile Ser Gly Asp Ser Ser Gly Phe Leu Leu Cys Ala Arg Gln Cys
  65                  70                  75                  80
 Phe Arg Tyr Phe Met His Ile Asn Leu Phe Asn Ser His Ser Asn Thr
                  85                  90                  95    
 Thr Thr His Val Leu Leu Leu Ser Ala Cys Ser Arg
             100                 105            



      <210> 1406
      <211> 258
      <212> PRT
      <213> Homo sapiens


      <400> 1406
 Met Ala Thr Val Leu Met Arg Thr Pro Ser Cys Leu Asp Gln Glu Ala
   1               5                  10                  15    
 Gly Ala Glu Glu Leu Gly Arg Thr Ser Glu Arg Ser Cys Val His Val
              20                  25                  30        
 Gly Pro Ala Gly Gln Phe Pro Gly Cys Ala Ala Thr Met Val Trp Phe
          35                  40                  45            
 Cys Asn Ser Ala Asp Cys Gln Phe Ser Val Phe Ala Leu Thr Thr Ile
      50                  55                  60                
 Gly Trp Ile Leu Ser Ser Thr Ser Thr Gly Leu Val Glu Trp Arg Ile
  65                  70                  75                  80
 Trp Tyr Met Lys Asp Thr Ser Leu Tyr Pro Pro Gly Ile Ala Cys Val
                  85                  90                  95    
 Gly Ile Phe Arg Val Cys Ile Tyr Arg Arg Arg Thr Asn Ser Thr Thr
             100                 105                 110        
 Thr Lys Phe Cys Tyr Arg Tyr Ser Tyr Gln Asp Thr Phe Leu Pro Phe
         115                 120                 125            
 Glu Ile Ser Met Ala Gln Arg Phe Leu Leu Thr Ala Ser Ile Phe Gly
     130                 135                 140                
 Phe Phe Gly Arg Ala Phe Asn Met Phe Ala Leu Arg Asn Met Ser Met
 145                 150                 155                 160
 Arg Met Phe Glu Glu Asp Thr Tyr Asn Ser Phe Val Val Ser Gly Ile
                 165                 170                 175    
 Leu Asn Ile Ala Ala Gly Val Phe Asn Leu Ile Ala Val Leu Gln Asn
             180                 185                 190        
 Tyr Asp Ala Val Ile Asn Ser Gln Gly Ile Thr Phe Leu Pro Ser Leu
         195                 200                 205            
 Gln Met Pro Phe Lys Pro Asp Val Gln Glu Val Gly Thr Ala Ile Gln
     210                 215                 220                
 Val Ala Gly Ile Gly Val Leu Pro Met Leu Leu Thr Gly Met Phe Ser
 225                 230                 235                 240
 Leu Phe Tyr Lys Cys Pro Pro Tyr Gly Gln Val His Pro Gly Ile Ser
                 245                 250                 255    
 Glu Met
        



      <210> 1407
      <211> 200
      <212> PRT
      <213> Homo sapiens


      <400> 1407
 Met Ala Leu Val Pro Cys Gln Val Leu Arg Met Ala Ile Leu Leu Ser
   1               5                  10                  15    
 Tyr Cys Ser Ile Leu Cys Asn Tyr Lys Ala Ile Glu Met Pro Ser His
              20                  25                  30        
 Gln Thr Tyr Gly Gly Ser Trp Lys Phe Leu Thr Phe Ile Asp Leu Val
          35                  40                  45            
 Ile Gln Ala Val Phe Phe Gly Ile Cys Val Leu Thr Asp Leu Ser Ser
      50                  55                  60                
 Leu Leu Thr Arg Gly Ser Gly Asn Gln Glu Gln Glu Arg Gln Leu Lys
  65                  70                  75                  80
 Lys Leu Ile Ser Leu Arg Asp Trp Met Leu Ala Val Leu Ala Phe Pro
                  85                  90                  95    
 Val Gly Val Phe Val Val Ala Val Phe Trp Ile Ile Tyr Ala Tyr Asp
             100                 105                 110        
 Arg Glu Met Ile Tyr Pro Lys Leu Leu Asp Asn Phe Ile Pro Gly Trp
         115                 120                 125            
 Leu Asn His Gly Met Trp Val Cys Trp Val His His Val Thr Gly Met
     130                 135                 140                
 Trp Val Tyr Pro Phe Leu Glu His Ile Gly Pro Gly Ala Arg Ile Ile
 145                 150                 155                 160
 Phe Phe Gly Ser Thr Thr Ile Leu Met Asn Phe Leu Tyr Leu Leu Gly
                 165                 170                 175    
 Glu Val Leu Asn Asn Tyr Ile Trp Asp Thr Gln Lys Ser Met Glu Glu
             180                 185                 190        
 Glu Lys Glu Lys Pro Lys Leu Glu
         195                 200



      <210> 1408
      <211> 458
      <212> PRT
      <213> Homo sapiens


      <400> 1408
 Met Ala Leu Trp Arg Gly Ser Ala Tyr Ala Gly Phe Leu Ala Leu Ala
   1               5                  10                  15    
 Val Gly Cys Val Phe Leu Leu Glu Pro Glu Leu Pro Gly Ser Ala Leu
              20                  25                  30        
 Arg Ser Leu Trp Ser Ser Leu Cys Leu Gly Pro Ala Pro Ala Pro Pro
          35                  40                  45            
 Gly Pro Val Ser Pro Glu Gly Arg Leu Ala Ala Ala Trp Asp Ala Leu
      50                  55                  60                
 Ile Val Arg Pro Val Arg Arg Trp Arg Arg Val Ala Val Gly Val Asn
  65                  70                  75                  80
 Ala Cys Val Asp Val Val Leu Ser Gly Val Lys Leu Leu Gln Ala Leu
                  85                  90                  95    
 Gly Leu Ser Pro Gly Asn Gly Lys Asp His Ser Ile Leu His Ser Arg
             100                 105                 110        
 Asn Asp Leu Glu Glu Ala Phe Ile His Phe Met Gly Lys Gly Ala Ala
         115                 120                 125            
 Ala Glu Arg Phe Phe Ser Asp Lys Glu Thr Phe His Asp Ile Ala Gln
     130                 135                 140                
 Val Ala Ser Glu Phe Pro Gly Ala Gln His Tyr Val Gly Gly Asn Ala
 145                 150                 155                 160
 Ala Leu Ile Gly Gln Lys Phe Ala Ala Asn Ser Asp Leu Lys Val Leu
                 165                 170                 175    
 Leu Cys Gly Pro Val Gly Pro Lys Leu His Glu Leu Leu Asp Asp Asn
             180                 185                 190        
 Val Phe Val Pro Pro Glu Ser Leu Gln Glu Val Asp Glu Phe His Leu
         195                 200                 205            
 Ile Leu Glu Tyr Gln Ala Gly Glu Glu Trp Gly Gln Leu Lys Ala Pro
     210                 215                 220                
 His Ala Asn Arg Phe Ile Phe Ser His Asp Leu Ser Asn Gly Ala Met
 225                 230                 235                 240
 Asn Met Leu Glu Val Phe Val Ser Ser Leu Glu Glu Phe Gln Pro Asp
                 245                 250                 255    
 Leu Val Val Leu Ser Gly Leu His Met Met Glu Gly Gln Ser Lys Glu
             260                 265                 270        
 Leu Gln Arg Lys Arg Leu Leu Glu Val Val Thr Ser Ile Ser Asp Ile
         275                 280                 285            
 Pro Thr Gly Ile Pro Val His Leu Glu Leu Ala Ser Met Thr Asn Arg
     290                 295                 300                
 Glu Leu Met Ser Ser Ile Val His Gln Gln Val Phe Pro Ala Val Thr
 305                 310                 315                 320
 Ser Leu Gly Leu Asn Glu Gln Glu Leu Leu Phe Leu Thr Gln Ser Ala
                 325                 330                 335    
 Ser Gly Pro His Ser Ser Leu Ser Ser Trp Asn Gly Val Pro Asp Val
             340                 345                 350        
 Gly Met Val Ser Asp Ile Leu Phe Trp Ile Leu Lys Glu His Gly Arg
         355                 360                 365            
 Ser Lys Ser Arg Ala Ser Asp Leu Thr Arg Ile His Phe His Thr Leu
     370                 375                 380                
 Val Tyr His Ile Leu Ala Thr Val Asp Gly His Trp Ala Asn Gln Leu
 385                 390                 395                 400
 Ala Ala Val Ala Ala Gly Ala Arg Val Ala Gly Thr Gln Ala Cys Ala
                 405                 410                 415    
 Thr Glu Thr Ile Asp Thr Ser Arg Val Ser Leu Arg Ala Pro Gln Asp
             420                 425                 430        
 Cys Ile Lys Pro Lys Gln Ala Ser Ser Arg Met Ala Gln Arg Gly Asn
         435                 440                 445            
 Ile Leu Pro Leu His Thr Ser Ile Gly Val
     450                 455            



      <210> 1409
      <211> 719
      <212> PRT
      <213> Homo sapiens


      <400> 1409
 Met Lys Thr Ala Pro Ala Gly Met Pro Met Thr Thr Gly His Gly Arg
   1               5                  10                  15    
 Leu Val Ala Glu Asp Glu Glu Ala Thr Gly Gly Pro Gly Gly Phe Gly
              20                  25                  30        
 Ser Ala Arg Ala Arg Gly Lys Glu His Glu Leu Pro His Asp Leu Pro
          35                  40                  45            
 Val Val Ala Lys Gly Met Gly Pro Gly Leu Ala His Val Lys Gly Asp
      50                  55                  60                
 Ser Gly Arg Ala Arg Lys Pro Gln Val Gln Pro Leu Pro Gly Glu Thr
  65                  70                  75                  80
 Ala Ala Thr Leu Gly Ser Ser Leu Leu Pro Gly Pro Pro Arg Ser Pro
                  85                  90                  95    
 Cys Pro Ser Asp Ser Met Pro Gln Pro His Pro Cys Lys Ala Leu Pro
             100                 105                 110        
 Arg Ser Pro Leu Ala Pro Lys Glu Pro Pro Asp Ala Cys Pro Pro Lys
         115                 120                 125            
 Met Ala Asp Lys Val Val Pro Arg Gln Val Ala Arg Leu Gly Arg Thr
     130                 135                 140                
 Met Arg Leu Gln Cys Pro Val Glu Gly Asp Pro Pro Pro Leu Thr Met
 145                 150                 155                 160
 Trp Thr Lys Asp Gly Arg Thr Ile His Ser Gly Trp Ser Arg Phe Arg
                 165                 170                 175    
 Val Leu Pro Gln Gly Leu Lys Val Lys Gln Val Glu Arg Glu Asp Ala
             180                 185                 190        
 Gly Val Tyr Val Cys Lys Thr Thr Asn Gly Phe Gly Ser Leu Ser Val
         195                 200                 205            
 Asn Tyr Thr Leu Val Val Leu Asp Asp Ile Ser Pro Gly Lys Glu Ser
     210                 215                 220                
 Leu Gly Pro Asp Ser Ser Ser Gly Gly Gln Glu Asp Pro Ala Ser Gln
 225                 230                 235                 240
 Gln Trp Ala Arg Pro Arg Phe Thr Gln Pro Ser Lys Met Arg Arg Arg
                 245                 250                 255    
 Val Ile Ala Arg Pro Val Gly Ser Ser Val Arg Leu Lys Cys Val Ala
             260                 265                 270        
 Ser Gly His Pro Arg Pro Asp Ile Thr Trp Met Lys Asp Asp Gln Ala
         275                 280                 285            
 Leu Thr Arg Pro Glu Ala Ala Glu Pro Arg Lys Lys Lys Trp Thr Leu
     290                 295                 300                
 Ser Leu Lys Asn Leu Arg Pro Glu Asp Ser Gly Lys Tyr Thr Cys Arg
 305                 310                 315                 320
 Val Ser Asn Arg Ala Gly Ala Ile Asn Ala Thr Tyr Lys Val Asp Val
                 325                 330                 335    
 Ile Gln Arg Thr Arg Ser Lys Pro Val Leu Thr Gly Thr His Pro Val
             340                 345                 350        
 Asn Thr Thr Val Asp Phe Gly Gly Thr Thr Ser Phe Gln Cys Lys Val
         355                 360                 365            
 Arg Ser Asp Val Lys Pro Val Ile Gln Trp Leu Lys Arg Val Glu Tyr
     370                 375                 380                
 Gly Ala Glu Gly Arg His Asn Ser Thr Ile Asp Val Gly Gly Gln Lys
 385                 390                 395                 400
 Phe Val Val Leu Pro Thr Gly Asp Val Trp Ser Arg Pro Asp Gly Ser
                 405                 410                 415    
 Tyr Leu Asn Lys Leu Leu Ile Thr Arg Ala Arg Gln Asp Asp Ala Gly
             420                 425                 430        
 Met Tyr Ile Cys Leu Gly Ala Asn Thr Met Gly Tyr Ser Phe Arg Ser
         435                 440                 445            
 Ala Phe Leu Thr Val Leu Pro Asp Pro Lys Pro Pro Gly Pro Pro Val
     450                 455                 460                
 Ala Ser Ser Ser Ser Ala Thr Ser Leu Pro Trp Pro Val Val Ile Gly
 465                 470                 475                 480
 Ile Pro Ala Gly Ala Val Phe Ile Leu Gly Thr Leu Leu Leu Trp Leu
                 485                 490                 495    
 Cys Gln Ala Gln Lys Lys Pro Cys Thr Pro Ala Pro Ala Pro Pro Leu
             500                 505                 510        
 Pro Gly His Arg Pro Pro Gly Thr Ala Arg Asp Arg Ser Gly Asp Lys
         515                 520                 525            
 Asp Leu Pro Ser Leu Ala Ala Leu Ser Ala Gly Pro Gly Val Gly Leu
     530                 535                 540                
 Cys Glu Glu His Gly Ser Pro Ala Ala Pro Gln His Leu Leu Gly Pro
 545                 550                 555                 560
 Gly Pro Val Ala Gly Pro Lys Leu Tyr Pro Lys Leu Tyr Thr Asp Ile
                 565                 570                 575    
 His Thr His Thr His Cys Ile Ala Ala Ala Cys Val Arg Ser Met Gly
             580                 585                 590        
 Leu Arg Gln Pro Pro Ser Thr Tyr Trp Ala Gln Ala Gln Leu Leu Ala
         595                 600                 605            
 Leu Ser Cys Thr Pro Asn Ser Thr Gln Thr Ser Thr His Thr His Thr
     610                 615                 620                
 His Thr Leu Thr His Thr His Thr Trp Arg Ala Arg Ser Thr Ser Thr
 625                 630                 635                 640
 Ser Thr Ile Ser Ala Arg Arg His Arg Ile Cys Arg Gly His Gly Gly
                 645                 650                 655    
 Ala Gly Gln Thr Gly Arg Leu Gly Gly Trp Arg Thr Glu Leu Gln Thr
             660                 665                 670        
 Lys Ala Gly Asp Pro Trp Arg Gly Gly Met Ala Ser Thr Pro Gly Ser
         675                 680                 685            
 Leu Cys Val Arg His Ser Pro Trp Thr His Thr His Arg His Thr His
     690                 695                 700                
 Tyr Leu Asp Ala Cys Met His Thr His Ala Arg Thr Arg Ala Pro
 705                 710                 715                



      <210> 1410
      <211> 357
      <212> PRT
      <213> Homo sapiens


      <400> 1410
 Met Arg Thr Leu Leu Thr Ile Leu Thr Val Gly Ser Leu Ala Ala His
   1               5                  10                  15    
 Ala Pro Glu Asp Pro Ser Asp Leu Leu Gln His Val Lys Phe Gln Ser
              20                  25                  30        
 Ser Asn Phe Glu Asn Ile Leu Thr Trp Asp Ser Gly Pro Glu Gly Thr
          35                  40                  45            
 Pro Asp Thr Val Tyr Ser Ile Glu Tyr Lys Thr Tyr Gly Glu Arg Asp
      50                  55                  60                
 Trp Val Ala Lys Lys Gly Cys Gln Arg Ile Thr Arg Lys Ser Cys Asn
  65                  70                  75                  80
 Leu Thr Val Glu Thr Gly Asn Leu Thr Glu Leu Tyr Tyr Ala Arg Val
                  85                  90                  95    
 Thr Ala Val Ser Ala Gly Gly Arg Ser Ala Thr Lys Met Thr Asp Arg
             100                 105                 110        
 Phe Ser Ser Leu Gln His Thr Thr Leu Lys Pro Pro Asp Val Thr Cys
         115                 120                 125            
 Ile Ser Lys Val Arg Ser Ile Gln Met Ile Val His Pro Thr Pro Thr
     130                 135                 140                
 Pro Ile Arg Ala Gly Asp Gly His Arg Leu Thr Leu Glu Asp Ile Phe
 145                 150                 155                 160
 His Asp Leu Phe Tyr His Leu Glu Leu Gln Val Asn Arg Thr Tyr Gln
                 165                 170                 175    
 Met His Leu Gly Gly Lys Gln Arg Glu Tyr Glu Phe Phe Gly Leu Thr
             180                 185                 190        
 Pro Asp Thr Glu Phe Leu Gly Thr Ile Met Ile Cys Val Pro Thr Trp
         195                 200                 205            
 Ala Lys Glu Ser Ala Pro Tyr Met Cys Arg Val Lys Thr Leu Pro Asp
     210                 215                 220                
 Arg Thr Trp Thr Tyr Ser Phe Ser Gly Ala Phe Leu Phe Ser Met Gly
 225                 230                 235                 240
 Phe Leu Val Ala Val Leu Cys Tyr Leu Ser Tyr Arg Tyr Val Thr Lys
                 245                 250                 255    
 Pro Pro Ala Pro Pro Asn Ser Leu Asn Val Gln Arg Val Leu Thr Phe
             260                 265                 270        
 Gln Pro Leu Arg Phe Ile Gln Glu His Val Leu Ile Pro Val Phe Asp
         275                 280                 285            
 Leu Ser Gly Pro Ser Ser Leu Ala Gln Pro Val Gln Tyr Ser Gln Ile
     290                 295                 300                
 Arg Val Ser Gly Pro Arg Glu Pro Ala Gly Ala Pro Gln Arg His Ser
 305                 310                 315                 320
 Pro Val Arg Asp His Leu Leu Arg Ala Ala Arg His Leu His Pro Pro
                 325                 330                 335    
 Ala Leu Gln Arg Ala Thr Ser Pro Asp Pro Leu Pro Thr Val Leu Cys
             340                 345                 350        
 Pro Lys Arg Cys Pro
         355        



      <210> 1411
      <211> 210
      <212> PRT
      <213> Homo sapiens


      <400> 1411
 Met Tyr Leu Val His Ser Ser Cys Leu Ile Cys Trp Leu Asn Lys Glu
   1               5                  10                  15    
 Trp Arg Phe Ser Lys Gly Ser Ile Glu Pro Leu Tyr Leu Thr Tyr Gly
              20                  25                  30        
 Ile Ile Phe Ala Cys Gly Cys Ser Phe Ala Tyr Gln Pro Ser Leu Val
          35                  40                  45            
 Ile Leu Gly His Tyr Phe Lys Lys Arg Leu Gly Leu Val Asn Gly Ile
      50                  55                  60                
 Val Thr Ala Gly Ser Ser Val Phe Thr Ile Leu Leu Pro Leu Leu Leu
  65                  70                  75                  80
 Arg Val Leu Ile Asp Ser Val Gly Leu Phe Tyr Thr Leu Arg Val Leu
                  85                  90                  95    
 Cys Ile Phe Met Phe Val Leu Phe Leu Ala Gly Phe Thr Tyr Arg Pro
             100                 105                 110        
 Leu Ala Thr Ser Thr Lys Asp Lys Glu Ser Gly Gly Ser Gly Ser Ser
         115                 120                 125            
 Leu Phe Ser Arg Lys Lys Phe Ser Pro Pro Lys Lys Ile Phe Asn Phe
     130                 135                 140                
 Ala Ile Phe Lys Val Thr Ala Tyr Ala Val Trp Ala Val Gly Ile Pro
 145                 150                 155                 160
 Leu Ala Leu Phe Gly Tyr Phe Val Pro Tyr Val His Leu Ala Cys Phe
                 165                 170                 175    
 Leu Thr Lys Tyr Val Asp Ile Val His Leu Arg Phe Ser Leu Ser His
             180                 185                 190        
 Asn Gly Ala Arg Tyr Arg Thr Glu Cys Ser Thr Val Glu Glu Arg Ser
         195                 200                 205            
 Asp Ser
     210



      <210> 1412
      <211> 346
      <212> PRT
      <213> Homo sapiens


      <400> 1412
 Met Ala Phe Thr Asp Leu Leu Asp Ala Leu Gly Ser Met Gly Arg Phe
   1               5                  10                  15    
 Gln Leu Asn His Thr Ala Leu Leu Leu Leu Pro Cys Gly Leu Leu Ala
              20                  25                  30        
 Cys His Asn Phe Leu Gln Asn Phe Thr Ala Ala Val Pro Pro His His
          35                  40                  45            
 Cys Arg Gly Pro Ala Asn His Thr Glu Ala Ser Thr Asn Asp Ser Gly
      50                  55                  60                
 Ala Trp Leu Arg Ala Thr Ile Pro Leu Asp Gln Leu Gly Ala Pro Glu
  65                  70                  75                  80
 Pro Cys Arg Arg Phe Thr Lys Pro Gln Trp Ala Leu Leu Ser Pro Asn
                  85                  90                  95    
 Ser Ser Ile Pro Gly Ala Ala Thr Glu Gly Cys Lys Asp Gly Trp Val
             100                 105                 110        
 Tyr Asn Arg Ser Val Phe Pro Ser Thr Ile Val Met Glu Val Arg Arg
         115                 120                 125            
 Gly Trp Val Cys Gly Gly Ala Ala Ala Glu Ala Gln Ser Glu Ala Pro
     130                 135                 140                
 Met Ser Ser Leu Gln Trp Asp Leu Val Cys Glu Ala Arg Thr Leu Arg
 145                 150                 155                 160
 Asp Leu Ala Gln Ser Val Tyr Ile Ala Gly Val Leu Val Gly Ala Ala
                 165                 170                 175    
 Val Phe Gly Ser Leu Ala Asp Arg Leu Gly Cys Lys Gly Pro Leu Val
             180                 185                 190        
 Trp Ser Tyr Leu Gln Leu Ala Ala Ser Gly Ala Ala Thr Ala Tyr Phe
         195                 200                 205            
 Ser Ser Phe Ser Ala Tyr Cys Val Phe Arg Phe Leu Met Gly Met Thr
     210                 215                 220                
 Phe Ser Gly Ile Ile Leu Asn Ser Val Ser Leu Leu Ser Leu Val His
 225                 230                 235                 240
 Cys Leu Ile Glu Ser Leu Leu Val Pro Gly Glu Ala Leu Glu Val Ala
                 245                 250                 255    
 Val Asn Thr Ala Leu Leu Leu Gly Val His Val Leu Ala Arg Arg Asp
             260                 265                 270        
 Ile Thr Ser Met His Asn Glu Ser Tyr Ser Met Phe Glu Asp Ile Val
         275                 280                 285            
 Glu Trp Met Pro Thr Arg Gly Arg Thr Val Ala Gly Ile Leu Leu Gly
     290                 295                 300                
 Tyr Ser Phe Thr Leu Gly Gln Leu Ile Leu Ala Gly Val Ala Tyr Leu
 305                 310                 315                 320
 Ile Arg Pro Trp Arg Cys Leu Gln Phe Ala Ile Ser Ala Pro Phe Leu
                 325                 330                 335    
 Ile Phe Phe Leu Tyr Ser Cys Gly Cys Ser
             340                 345    



      <210> 1413
      <211> 606
      <212> PRT
      <213> Homo sapiens


      <400> 1413
 Met Gly Ser Thr Lys Gly Ser Ser Val Gly Leu Glu Arg Pro Arg Ala
   1               5                  10                  15    
 Arg Ala Gly Cys Pro Arg Pro Leu Ala Ala Pro Arg Glu Val Leu Ser
              20                  25                  30        
 Ser Thr Arg Pro Leu Tyr Ala Met Ser Pro Pro Gly Ser Ala Ala Gly
          35                  40                  45            
 Glu Ser Ala Ala Gly Gly Gly Gly Gly Gly Gly Gly Pro Gly Val Ser
      50                  55                  60                
 Glu Glu Leu Thr Ala Ala Ala Ala Ala Ala Ala Ala Asp Glu Gly Pro
  65                  70                  75                  80
 Ala Arg Glu Glu Gln Gln Arg Pro Ile Gln Pro Ser Phe Thr Lys Ser
                  85                  90                  95    
 Leu Cys Arg Glu Ser His Trp Lys Cys Leu Leu Leu Ser Leu Leu Met
             100                 105                 110        
 Tyr Gly Cys Leu Gly Ala Val Ala Trp Cys His Val Thr Thr Val Thr
         115                 120                 125            
 Arg Leu Thr Phe Ser Ser Ala Tyr Gln Gly Asn Ser Leu Met Tyr His
     130                 135                 140                
 Asp Ser Pro Cys Ser Asn Gly Tyr Val Tyr Ile Pro Leu Ala Phe Leu
 145                 150                 155                 160
 Leu Met Leu Tyr Ala Val Tyr Leu Val Glu Cys Trp His Cys Gln Ala
                 165                 170                 175    
 Arg His Glu Leu Gln His Arg Val Asp Val Ser Ser Val Arg Glu Arg
             180                 185                 190        
 Val Gly Arg Met Gln Gln Ala Thr Pro Cys Ile Trp Trp Lys Ala Ile
         195                 200                 205            
 Ser Tyr His Tyr Val Arg Arg Thr Arg Gln Val Thr Arg Tyr Arg Asn
     210                 215                 220                
 Gly Asp Ala Tyr Thr Thr Thr Gln Val Tyr His Glu Arg Val Asn Thr
 225                 230                 235                 240
 His Val Ala Glu Ala Glu Phe Asp Tyr Ala Arg Cys Gly Val Arg Asp
                 245                 250                 255    
 Val Ser Lys Thr Leu Val Gly Leu Glu Gly Ala Pro Ala Thr Arg Leu
             260                 265                 270        
 Arg Phe Thr Lys Cys Phe Ser Phe Ala Ser Val Glu Ala Glu Asn Ala
         275                 280                 285            
 Tyr Leu Cys Gln Arg Ala Arg Phe Phe Ala Glu Asn Glu Gly Leu Asp
     290                 295                 300                
 Asp Tyr Met Glu Ala Arg Glu Gly Met His Leu Lys Asn Val Asp Phe
 305                 310                 315                 320
 Arg Glu Phe Met Val Ala Phe Pro Asp Pro Ala Arg Pro Pro Trp Tyr
                 325                 330                 335    
 Ala Cys Ser Ser Ala Phe Trp Ala Ala Ala Leu Leu Thr Leu Ser Trp
             340                 345                 350        
 Pro Leu Arg Val Leu Ala Glu Tyr Arg Thr Ala Tyr Ala His Tyr His
         355                 360                 365            
 Val Glu Lys Leu Phe Gly Leu Glu Gly Pro Gly Ser Ala Ser Ser Ala
     370                 375                 380                
 Gly Gly Gly Leu Ser Pro Ser Asp Glu Leu Leu Pro Pro Leu Thr His
 385                 390                 395                 400
 Arg Leu Pro Arg Val Asn Thr Val Asp Ser Thr Glu Leu Glu Trp His
                 405                 410                 415    
 Ile Arg Ser Asn Gln Gln Leu Val Pro Ser Tyr Ser Glu Ala Val Leu
             420                 425                 430        
 Met Asp Leu Ala Gly Leu Gly Thr Arg Cys Gly Gly Ala Gly Gly Gly
         435                 440                 445            
 Tyr Ala Pro Ser Cys Arg Tyr Gly Gly Val Gly Gly Pro Gly Ala Ala
     450                 455                 460                
 Gly Val Ala Pro Tyr Arg Arg Ser Cys Glu His Cys Gln Arg Ala Val
 465                 470                 475                 480
 Ser Ser Ser Ser Ile Phe Ser Arg Ser Ala Leu Ser Ile Cys Ala Ser
                 485                 490                 495    
 Pro Arg Ala Gly Pro Gly Pro Gly Gly Gly Ala Gly Cys Gly Gly Ser
             500                 505                 510        
 Arg Phe Ser Leu Gly Arg Leu Tyr Gly Ser Arg Arg Ser Cys Leu Trp
         515                 520                 525            
 Arg Ser Arg Ser Gly Ser Val Asn Glu Ala Ser Cys Pro Thr Glu Gln
     530                 535                 540                
 Thr Arg Leu Ser Ser Gln Ala Ser Met Gly Asp Asp Glu Asp Asp Asp
 545                 550                 555                 560
 Glu Glu Glu Ala Gly Pro Pro Pro Pro Tyr His Asp Ala Leu Tyr Phe
                 565                 570                 575    
 Pro Val Leu Ile Val His Arg Gln Glu Gly Cys Leu Gly His Ser His
             580                 585                 590        
 Arg Pro Leu His Arg His Gly Ser Cys Val Glu Thr Ser Leu
         595                 600                 605    



      <210> 1414
      <211> 338
      <212> PRT
      <213> Homo sapiens


      <400> 1414
 Met Val Ser Gly Thr Ser Ala Ala Ala Pro Gln Gly Pro Arg Ala Ser
   1               5                  10                  15    
 Pro Ala Ala Leu Ala Thr Trp Gln Pro Pro Pro Trp Lys Ser Thr Val
              20                  25                  30        
 Val Asn Leu Ala Pro Arg Ser Ile Met His Cys Val Ala Leu Ala Gly
          35                  40                  45            
 Val Leu Ser Cys Gly Leu Thr His Thr Ala Val Val Pro Leu Asp Leu
      50                  55                  60                
 Val Lys Cys Arg Met Gln Val Asp Pro Gln Lys Tyr Lys Gly Ile Phe
  65                  70                  75                  80
 Asn Gly Phe Ser Val Thr Leu Lys Glu Asp Gly Val Arg Gly Leu Ala
                  85                  90                  95    
 Lys Gly Trp Ala Pro Thr Phe Leu Gly Tyr Ser Met Gln Gly Leu Cys
             100                 105                 110        
 Lys Phe Gly Phe Tyr Glu Val Phe Lys Val Leu Tyr Ser Asn Met Leu
         115                 120                 125            
 Gly Glu Glu Asn Thr Tyr Leu Trp Arg Thr Ser Leu Tyr Leu Ala Ala
     130                 135                 140                
 Ser Ala Ser Ala Glu Phe Phe Ala Asp Ile Ala Leu Ala Pro Met Glu
 145                 150                 155                 160
 Ala Ala Lys Val Arg Ile Gln Thr Gln Pro Gly Tyr Ala Asn Thr Leu
                 165                 170                 175    
 Arg Asp Ala Ala Pro Lys Met Tyr Lys Glu Glu Gly Leu Lys Ala Phe
             180                 185                 190        
 Tyr Lys Gly Val Ala Pro Leu Trp Met Arg Gln Ile Pro Tyr Thr Met
         195                 200                 205            
 Met Lys Phe Ala Cys Phe Glu Arg Thr Val Glu Ala Leu Tyr Lys Phe
     210                 215                 220                
 Val Val Pro Lys Pro Arg Ser Glu Cys Ser Lys Pro Glu Gln Leu Val
 225                 230                 235                 240
 Val Thr Phe Val Ala Gly Tyr Ile Ala Gly Val Phe Cys Ala Ile Val
                 245                 250                 255    
 Ser His Pro Ala Asp Ser Val Val Ser Val Leu Asn Lys Glu Lys Gly
             260                 265                 270        
 Ser Ser Ala Ser Leu Val Leu Lys Arg Leu Gly Phe Lys Gly Val Trp
         275                 280                 285            
 Lys Gly Leu Phe Ala Arg Ile Ile Met Ile Gly Thr Leu Thr Ala Leu
     290                 295                 300                
 Gln Trp Phe Ile Tyr Asp Ser Val Lys Val Tyr Phe Arg Leu Pro Arg
 305                 310                 315                 320
 Pro Pro Pro Pro Glu Met Pro Glu Ser Leu Lys Lys Lys Leu Gly Leu
                 325                 330                 335    
 Thr Gln
        



      <210> 1415
      <211> 402
      <212> PRT
      <213> Homo sapiens


      <400> 1415
 Met Glu Gly Gly Asp Leu Cys Glu Thr Gly Asp Ala Glu Pro Val Leu
   1               5                  10                  15    
 Gly Glu Cys His Val Ala Glu Asn Ser Asp Ser Ser Ser Gly Phe Gly
              20                  25                  30        
 Glu Leu Trp Gly Val Gly Gln Val Pro Gly Arg Asp Glu Gln Lys Pro
          35                  40                  45            
 Asp Arg Gly Val Cys Gly Arg Leu Leu Ser Arg Gln Leu His Cys Ala
      50                  55                  60                
 Leu Arg Leu Met Ser Lys Val Leu Thr Val Trp Val Cys Val Phe Pro
  65                  70                  75                  80
 Ala Gly Val Ser Ser Val Thr Ser Leu Met Ser Leu Ala Trp Val Leu
                  85                  90                  95    
 Ala Ser Tyr His Lys Leu Leu Arg Asp Ser Arg Asp Asp Lys Lys Ser
             100                 105                 110        
 Met Ser Tyr Arg Gly Ala Ile Ile Gln Val Phe Trp Arg Leu Phe Thr
         115                 120                 125            
 Ile Ser Ser Arg Val Ile Ser Phe Ala Leu Phe Ala Ser Ile Phe Gln
     130                 135                 140                
 Leu Tyr Phe Gly Ile Phe Val Val Val His Trp Cys Ala Met Ala Phe
 145                 150                 155                 160
 Trp Ile Ile His Gly Gly Thr Asp Phe Cys Met Ser Lys Trp Glu Glu
                 165                 170                 175    
 Ile Leu Phe Asn Met Val Val Gly Ile Val Tyr Ile Phe Cys Trp Phe
             180                 185                 190        
 Asn Val Lys Glu Gly Arg Thr Arg Tyr Arg Met Phe Ala Tyr Tyr Thr
         195                 200                 205            
 Ile Val Leu Thr Glu Asn Ala Ala Leu Thr Phe Leu Trp Tyr Phe Tyr
     210                 215                 220                
 Arg Asp Pro Glu Thr Thr Asp Ser Tyr Ala Val Pro Ala Leu Cys Cys
 225                 230                 235                 240
 Val Phe Ile Ser Phe Val Ala Gly Ile Ala Met Met Leu Leu Tyr Tyr
                 245                 250                 255    
 Gly Val Leu His Pro Thr Gly Pro Arg Ala Lys Ile Leu Ala Ser Ser
             260                 265                 270        
 Cys Cys Ala Glu Leu Leu Trp Gly Ile Pro Leu Pro Pro Asp Val Glu
         275                 280                 285            
 Pro Met Ala Pro Glu Ile Pro Gly Tyr Arg Gly Thr Gln Val Thr Pro
     290                 295                 300                
 Thr Arg Ala Val Thr Glu Gln Gln Glu Asp Leu Thr Ala Asp Thr Cys
 305                 310                 315                 320
 Leu Pro Val Phe Gln Val Arg Pro Met Gly Pro Pro Thr Pro Leu Gly
                 325                 330                 335    
 Arg Pro Tyr Leu Pro Glu Gly Pro Leu Ile Lys Ile Asp Met Pro Arg
             340                 345                 350        
 Lys Arg Tyr Pro Ala Trp Asp Ala His Phe Val Asp Arg Arg Leu Arg
         355                 360                 365            
 Arg Thr Ile Asn Ile Leu Gln Tyr Val Thr Pro Thr Ala Val Gly Ile
     370                 375                 380                
 Arg Tyr Arg Asp Gly Pro Leu Leu Tyr Glu Leu Leu Gln Tyr Glu Ser
 385                 390                 395                 400
 Ser Leu
        



      <210> 1416
      <211> 268
      <212> PRT
      <213> Homo sapiens


      <400> 1416
 Met Gly Lys Lys Thr Gln Arg Ser Leu Ser Ala Glu Leu Glu Ile Pro
   1               5                  10                  15    
 Ala Val Lys Glu Ser Asp Ala Gly Lys Tyr Tyr Cys Arg Ala Asp Asn
              20                  25                  30        
 Gly His Val Pro Ile Gln Ser Lys Val Val Asn Ile Pro Val Arg Ser
          35                  40                  45            
 Leu Leu Gly Pro Gln Ala Ala Gly Gly Asp Leu Leu Glu Leu His Cys
      50                  55                  60                
 Glu Ala Leu Arg Gly Ser Pro Leu Ile Leu Tyr Arg Phe Phe His Glu
  65                  70                  75                  80
 Asp Val Thr Leu Gly Asn Arg Ser Ser Pro Ser Gly Gly Ala Ser Leu
                  85                  90                  95    
 Asn Leu Ser Leu Thr Ala Glu His Ser Gly Asn Tyr Ser Cys Glu Ala
             100                 105                 110        
 Asp Asn Gly Leu Gly Ala Gln Arg Ser Glu Thr Val Thr Leu Tyr Ile
         115                 120                 125            
 Thr Gly Leu Thr Ala Asn Arg Ser Gly Pro Phe Ala Thr Gly Val Ala
     130                 135                 140                
 Gly Gly Leu Leu Ser Ile Ala Gly Leu Ala Ala Gly Ala Leu Leu Leu
 145                 150                 155                 160
 Tyr Cys Trp Leu Ser Arg Lys Ala Gly Arg Lys Pro Ala Ser Asp Pro
                 165                 170                 175    
 Ala Arg Ser Pro Ser Asp Ser Asp Ser Gln Glu Pro Thr Tyr His Asn
             180                 185                 190        
 Val Pro Ala Trp Glu Glu Leu Gln Pro Val Tyr Thr Asn Ala Asn Pro
         195                 200                 205            
 Arg Gly Glu Asn Val Val Tyr Ser Glu Val Arg Ile Ile Gln Lys Lys
     210                 215                 220                
 Lys Lys His Ala Val Ala Ser Asp Pro Arg His Leu Arg Asn Lys Gly
 225                 230                 235                 240
 Ser Pro Ile Ile Tyr Ser Glu Val Lys Val Ala Ser Thr Pro Val Ser
                 245                 250                 255    
 Gly Ser Leu Phe Leu Ala Ser Ser Ala Pro His Arg
             260                 265            



      <210> 1417
      <211> 162
      <212> PRT
      <213> Homo sapiens


      <400> 1417
 Met Ala Ala Ala Glu Glu Glu Asp Gly Gly Pro Glu Gly Pro Asn Arg
   1               5                  10                  15    
 Glu Arg Gly Gly Ala Gly Ala Thr Phe Glu Cys Asn Ile Cys Leu Glu
              20                  25                  30        
 Thr Ala Arg Glu Ala Val Val Ser Val Cys Gly His Leu Tyr Cys Trp
          35                  40                  45            
 Pro Cys Leu His Gln Trp Leu Glu Thr Arg Pro Glu Arg Gln Glu Cys
      50                  55                  60                
 Pro Val Cys Lys Ala Gly Ile Ser Arg Glu Lys Val Val Pro Leu Tyr
  65                  70                  75                  80
 Gly Arg Gly Ser Gln Lys Pro Gln Asp Pro Arg Leu Phe Gln Pro Phe
                  85                  90                  95    
 Gly Asp Thr Gly Gly Phe His Phe Ser Phe Gly Val Gly Ala Phe Pro
             100                 105                 110        
 Phe Gly Phe Phe Thr Thr Val Phe Asn Ala His Glu Pro Phe Arg Arg
         115                 120                 125            
 Gly Thr Gly Val Asp Leu Gly Gln Gly His Pro Ala Ser Ser Trp Gln
     130                 135                 140                
 Asp Ser Leu Phe Leu Phe Leu Ala Ile Phe Phe Phe Phe Trp Leu Leu
 145                 150                 155                 160
 Ser Ile
        



      <210> 1418
      <211> 272
      <212> PRT
      <213> Homo sapiens


      <400> 1418
 Met Ser Ser Thr Glu Ser Ala Gly Arg Thr Ala Asp Lys Ser Pro Arg
   1               5                  10                  15    
 Gln Gln Val Asp Arg Leu Leu Val Gly Leu Arg Trp Arg Arg Leu Glu
              20                  25                  30        
 Glu Pro Leu Gly Phe Ile Lys Val Leu Gln Trp Leu Phe Ala Ile Phe
          35                  40                  45            
 Ala Phe Gly Ser Cys Gly Ser Tyr Ser Gly Glu Thr Gly Ala Met Val
      50                  55                  60                
 Arg Cys Asn Asn Glu Ala Lys Asp Val Ser Ser Ile Ile Val Ala Phe
  65                  70                  75                  80
 Gly Tyr Pro Phe Arg Leu His Arg Ile Gln Tyr Glu Met Pro Leu Cys
                  85                  90                  95    
 Asp Glu Glu Ser Ser Ser Lys Thr Met His Leu Met Gly Asp Phe Ser
             100                 105                 110        
 Ala Pro Ala Glu Phe Phe Val Thr Leu Gly Ile Phe Ser Phe Phe Tyr
         115                 120                 125            
 Thr Met Ala Ala Leu Val Ile Tyr Leu Arg Phe His Asn Leu Tyr Thr
     130                 135                 140                
 Glu Asn Lys Arg Phe Pro Leu Val Asp Phe Cys Val Thr Val Ser Phe
 145                 150                 155                 160
 Thr Phe Phe Trp Leu Val Ala Ala Ala Ala Trp Gly Lys Gly Leu Thr
                 165                 170                 175    
 Asp Val Lys Gly Ala Thr Arg Pro Ser Ser Leu Thr Ala Ala Met Ser
             180                 185                 190        
 Val Cys His Gly Glu Glu Ala Val Cys Ser Ala Gly Ala Thr Pro Ser
         195                 200                 205            
 Met Gly Leu Ala Asn Ile Ser Val Leu Phe Gly Phe Ile Asn Phe Phe
     210                 215                 220                
 Leu Trp Ala Gly Asn Cys Trp Phe Val Phe Lys Glu Thr Pro Trp His
 225                 230                 235                 240
 Gly Gln Gly Gln Gly Gln Asp Gln Asp Gln Asp Gln Asp Gln Gly Gln
                 245                 250                 255    
 Gly Pro Ser Gln Glu Ser Ala Ala Glu Gln Gly Ala Val Glu Lys Gln
             260                 265                 270        





      <210> 1419
      <211> 185
      <212> PRT
      <213> Homo sapiens


      <400> 1419
 Met Ala Ser Ala Gly Leu Gln Leu Leu Ala Phe Ile Leu Ala Leu Ser
   1               5                  10                  15    
 Gly Val Ser Gly Val Leu Thr Ala Thr Leu Leu Pro Asn Trp Lys Val
              20                  25                  30        
 Asn Val Asp Val Asp Ser Asn Ile Ile Thr Ala Ile Val Gln Leu His
          35                  40                  45            
 Gly Leu Trp Met Asp Cys Thr Trp Tyr Ser Thr Gly Met Phe Ser Cys
      50                  55                  60                
 Ala Leu Lys His Ser Ile Leu Ser Leu Pro Ile His Val Gln Ala Ala
  65                  70                  75                  80
 Arg Ala Thr Met Val Leu Ala Cys Val Leu Ser Ala Leu Gly Ile Cys
                  85                  90                  95    
 Thr Ser Thr Val Gly Met Lys Cys Thr Arg Leu Gly Gly Asp Arg Glu
             100                 105                 110        
 Thr Lys Ser His Ala Ser Phe Ala Gly Gly Val Cys Phe Met Ser Ala
         115                 120                 125            
 Gly Ile Ser Ser Leu Ile Ser Thr Val Trp Tyr Thr Lys Glu Ile Ile
     130                 135                 140                
 Ala Asn Phe Leu Asp Leu Thr Val Pro Glu Ser Asn Lys His Glu Pro
 145                 150                 155                 160
 Gly Gly Ala Ile Ser Gly Leu Gly Thr Lys Ala Cys Pro Gly Ile Val
                 165                 170                 175    
 Lys Met Cys Arg Thr Leu Gln Arg Tyr
             180                 185



      <210> 1420
      <211> 147
      <212> PRT
      <213> Homo sapiens


      <400> 1420
 Met Ile Thr Leu Thr Glu Leu Lys Cys Leu Ala Asp Ala Gln Ser Ser
   1               5                  10                  15    
 Tyr His Ile Leu Lys Pro Trp Trp Asp Val Phe Trp Tyr Tyr Ile Thr
              20                  25                  30        
 Leu Ile Met Leu Leu Val Ala Val Leu Ala Gly Ala Leu Gln Leu Thr
          35                  40                  45            
 Gln Ser Arg Val Leu Cys Cys Leu Pro Cys Lys Val Glu Phe Asp Asn
      50                  55                  60                
 His Cys Ala Val Pro Trp Asp Ile Leu Lys Ala Ser Met Asn Thr Ser
  65                  70                  75                  80
 Ser Asn Pro Gly Thr Pro Leu Pro Leu Pro Leu Arg Ile Gln Asn Asp
                  85                  90                  95    
 Leu His Arg Gln Gln Tyr Ser Tyr Ile Asp Ala Val Cys Tyr Glu Lys
             100                 105                 110        
 Gln Leu His Trp Phe Ala Lys Phe Phe Pro Tyr Leu Val Ala Leu Ala
         115                 120                 125            
 His Ala His Leu Cys Asn Leu Gln Gln Leu Trp Ala Ser Leu Pro Gln
     130                 135                 140                
 Tyr Gln Ser
 145        



      <210> 1421
      <211> 395
      <212> PRT
      <213> Homo sapiens


      <400> 1421
 Met Ala Gly Ser Pro Ser Arg Ala Ala Gly Arg Arg Leu Gln Leu Pro
   1               5                  10                  15    
 Leu Leu Cys Leu Phe Leu Gln Gly Ala Thr Ala Val Leu Phe Ala Val
              20                  25                  30        
 Phe Val Arg Tyr Asn His Lys Thr Asp Ala Ala Leu Trp His Arg Ser
          35                  40                  45            
 Asn His Ser Asn Ala Asp Asn Glu Phe Tyr Phe Arg Tyr Pro Ser Phe
      50                  55                  60                
 Gln Asp Val His Ala Met Val Phe Val Gly Phe Asp Phe Leu Met Val
  65                  70                  75                  80
 Phe Leu Gln Arg Tyr Gly Phe Ser Ser Val Gly Phe Thr Phe Leu Leu
                  85                  90                  95    
 Ala Ala Phe Ala Leu Gln Trp Ser Thr Leu Val Gln Gly Phe Leu His
             100                 105                 110        
 Ser Phe His Gly Gly His Ile His Val Gly Val Glu Ser Met Ile Asn
         115                 120                 125            
 Ala Asp Phe Cys Ala Gly Ala Val Leu Ile Ser Phe Gly Ala Val Leu
     130                 135                 140                
 Gly Lys Thr Gly Pro Thr Gln Leu Leu Leu Met Ala Leu Leu Glu Val
 145                 150                 155                 160
 Val Leu Phe Gly Ile Asn Glu Phe Val Leu Leu His Leu Leu Gly Val
                 165                 170                 175    
 Arg Asp Ala Gly Gly Ser Met Thr Ile His Thr Phe Gly Ala Tyr Phe
             180                 185                 190        
 Gly Leu Val Leu Ser Arg Val Leu Tyr Arg Pro Gln Leu Glu Lys Ser
         195                 200                 205            
 Lys His Arg Gln Gly Ser Val Tyr His Ser Asp Leu Phe Ala Met Ile
     210                 215                 220                
 Gly Thr Ile Phe Leu Trp Ile Phe Trp Pro Ser Phe Asn Ala Ala Leu
 225                 230                 235                 240
 Thr Ala Leu Gly Ala Gly Gln His Arg Thr Ala Leu Asn Thr Tyr Tyr
                 245                 250                 255    
 Ser Leu Ala Ala Ser Thr Leu Gly Thr Phe Ala Leu Ser Ala Leu Val
             260                 265                 270        
 Gly Glu Asp Gly Arg Leu Asp Met Pro Ile Leu Glu Ser Lys Phe Lys
         275                 280                 285            
 Val Gln Asp Thr Cys Gly Val His Asn Leu His Gly Met Pro Gly Val
     290                 295                 300                
 Leu Gly Ala Leu Leu Gly Val Leu Val Ala Gly Leu Ala Thr His Glu
 305                 310                 315                 320
 Ala Tyr Gly Asp Gly Leu Glu Ser Val Phe Pro Leu Ile Ala Glu Gly
                 325                 330                 335    
 Gln Arg Ser Ala Thr Ser Gln Ala Met His Gln Leu Phe Gly Leu Phe
             340                 345                 350        
 Val Thr Leu Met Phe Ala Ser Val Gly Gly Gly Leu Gly Gly Leu Leu
         355                 360                 365            
 Leu Lys Leu Pro Phe Leu Asp Ser Pro Pro Arg Leu Pro Ala Leu Arg
     370                 375                 380                
 Gly Pro Ser Ser Leu Ala Gly Ala Trp Arg Ala
 385                 390                 395



      <210> 1422
      <211> 239
      <212> PRT
      <213> Homo sapiens


      <400> 1422
 Met Ala Ser Leu Phe His Gln Leu Gln Ile Leu Val Trp Lys Asn Trp
   1               5                  10                  15    
 Leu Gly Val Lys Arg Gln Pro Leu Trp Thr Leu Val Leu Ile Leu Trp
              20                  25                  30        
 Pro Val Ile Ile Phe Ile Ile Leu Ala Ile Thr Arg Thr Lys Phe Pro
          35                  40                  45            
 Pro Thr Ala Lys Pro Thr Cys Tyr Leu Ala Pro Arg Asn Leu Pro Ser
      50                  55                  60                
 Thr Gly Phe Phe Pro Phe Leu Gln Thr Leu Leu Cys Asp Thr Asp Ser
  65                  70                  75                  80
 Lys Cys Lys Asp Thr Pro Tyr Gly Pro Gln Asp Leu Leu Arg Arg Lys
                  85                  90                  95    
 Gly Ile Asp Asp Ala Leu Phe Lys Asp Ser Glu Ile Leu Arg Lys Ser
             100                 105                 110        
 Ser Asn Leu Asp Lys Asp Ser Ser Leu Ser Phe Gln Ser Thr Gln Val
         115                 120                 125            
 Pro Glu Arg Arg His Ala Ser Leu Ala Thr Val Phe Pro Ser Pro Ser
     130                 135                 140                
 Ser Asp Leu Glu Ile Pro Gly Thr Tyr Thr Phe Asn Gly Ser Gln Val
 145                 150                 155                 160
 Leu Ala Arg Ile Leu Gly Leu Glu Lys Leu Leu Lys Gln Asn Ser Thr
                 165                 170                 175    
 Ser Glu Asp Ile Arg Arg Glu Leu Cys Asp Ser Tyr Ser Gly Tyr Ile
             180                 185                 190        
 Val Asp Asp Ala Phe Ser Trp Thr Phe Leu Gly Arg Asn Val Phe Asn
         195                 200                 205            
 Lys Phe Cys Leu Ser Asn Met Thr Leu Leu Glu Ser Ser Leu Gln Glu
     210                 215                 220                
 Leu Asn Lys Gln Phe Ser Gln Thr Glu Glu Leu Gln Tyr Gln Arg
 225                 230                 235                



      <210> 1423
      <211> 166
      <212> PRT
      <213> Homo sapiens


      <400> 1423
 Met Ala Pro Ala Arg Ala Gly Phe Cys Pro Leu Leu Leu Leu Leu Leu
   1               5                  10                  15    
 Leu Gly Leu Trp Val Ala Glu Ile Pro Val Ser Ala Lys Pro Lys Gly
              20                  25                  30        
 Met Thr Ser Ser Gln Trp Phe Lys Ile Gln His Met Gln Pro Ser Pro
          35                  40                  45            
 Gln Ala Cys Asn Ser Ala Met Lys Asn Ile Asn Lys His Thr Lys Arg
      50                  55                  60                
 Cys Lys Asp Leu Asn Thr Phe Leu His Glu Pro Phe Ser Ser Val Ala
  65                  70                  75                  80
 Ala Thr Cys Gln Thr Pro Lys Ile Ala Cys Lys Asn Gly Asp Lys Asn
                  85                  90                  95    
 Cys His Gln Ser His Gly Ala Val Ser Leu Thr Met Cys Lys Leu Thr
             100                 105                 110        
 Ser Gly Lys Tyr Pro Asn Cys Arg Tyr Lys Glu Lys Arg Gln Asn Lys
         115                 120                 125            
 Ser Tyr Val Val Ala Leu Tyr Leu Leu Leu Tyr Gln Leu Arg Lys Lys
     130                 135                 140                
 Glu Val Thr Val Thr Glu Ala Ser Gly Glu Leu Gly Lys Ser Ser Leu
 145                 150                 155                 160
 Met Lys Lys Arg Val Leu
                 165    



      <210> 1424
      <211> 764
      <212> PRT
      <213> Homo sapiens


      <400> 1424
 Met Gly Pro Ala Pro Ala Gly Glu Gln Leu Arg Gly Ala Thr Gly Glu
   1               5                  10                  15    
 Pro Glu Val Met Glu Pro Ala Leu Glu Gly Thr Gly Lys Glu Gly Lys
              20                  25                  30        
 Lys Ala Ser Ser Arg Lys Arg Thr Leu Ala Glu Pro Pro Ala Lys Gly
          35                  40                  45            
 Leu Leu Gln Pro Val Lys Leu Ser Arg Ala Glu Leu Tyr Lys Glu Pro
      50                  55                  60                
 Thr Asn Glu Glu Leu Asn Arg Leu Arg Glu Thr Glu Ile Leu Phe His
  65                  70                  75                  80
 Ser Ser Leu Leu Arg Leu Gln Val Glu Glu Leu Leu Lys Glu Val Arg
                  85                  90                  95    
 Leu Ser Glu Lys Lys Lys Asp Arg Ile Asp Ala Phe Leu Arg Glu Val
             100                 105                 110        
 Asn Gln Arg Val Val Arg Val Pro Ser Val Pro Glu Thr Glu Leu Thr
         115                 120                 125            
 Asp Gln Ala Trp Leu Pro Ala Gly Val Arg Val Pro Leu His Gln Val
     130                 135                 140                
 Pro Tyr Ala Val Lys Gly Cys Phe Arg Phe Leu Pro Pro Ala Gln Val
 145                 150                 155                 160
 Thr Val Val Gly Ser Tyr Leu Leu Gly Thr Cys Ile Arg Pro Asp Ile
                 165                 170                 175    
 Asn Val Asp Val Ala Leu Thr Met Pro Arg Glu Ile Leu Gln Asp Lys
             180                 185                 190        
 Asp Gly Leu Asn Gln Arg Tyr Phe Arg Lys Arg Ala Leu Tyr Leu Ala
         195                 200                 205            
 His Leu Ala His His Leu Ala Gln Asp Pro Leu Phe Gly Ser Val Cys
     210                 215                 220                
 Phe Ser Tyr Thr Asn Gly Cys His Leu Lys Pro Ser Leu Leu Leu Arg
 225                 230                 235                 240
 Pro Arg Gly Lys Asp Glu Arg Leu Val Thr Val Arg Leu His Pro Cys
                 245                 250                 255    
 Pro Pro Pro Asp Phe Phe Arg Pro Cys Arg Leu Leu Pro Thr Lys Asn
             260                 265                 270        
 Asn Val Arg Ser Ala Trp Tyr Arg Gly Gln Ser Pro Ala Gly Asp Gly
         275                 280                 285            
 Ser Pro Glu Pro Pro Thr Pro Arg Tyr Asn Thr Trp Val Leu Gln Asp
     290                 295                 300                
 Thr Val Leu Glu Ser His Leu Gln Leu Leu Ser Thr Ile Leu Ser Ser
 305                 310                 315                 320
 Ala Gln Gly Leu Lys Asp Gly Val Ala Leu Leu Lys Val Trp Leu Arg
                 325                 330                 335    
 Gln Arg Glu Leu Asp Lys Gly Gln Gly Gly Phe Thr Gly Phe Leu Val
             340                 345                 350        
 Ser Met Leu Val Val Phe Leu Val Ser Thr Arg Lys Ile His Thr Thr
         355                 360                 365            
 Met Ser Gly Tyr Gln Val Leu Arg Ser Val Leu Gln Phe Leu Ala Thr
     370                 375                 380                
 Thr Asp Leu Thr Val Asn Gly Ile Ser Leu Cys Leu Ser Ser Asp Pro
 385                 390                 395                 400
 Ser Leu Pro Ala Leu Ala Asp Phe His Gln Ala Phe Ser Val Val Phe
                 405                 410                 415    
 Leu Asp Ser Ser Gly His Leu Asn Leu Cys Ala Asp Val Thr Ala Ser
             420                 425                 430        
 Thr Tyr His Gln Val Gln His Glu Ala Arg Leu Ser Met Met Leu Leu
         435                 440                 445            
 Asp Ser Arg Ala Asp Asp Gly Phe His Leu Leu Leu Met Thr Pro Lys
     450                 455                 460                
 Pro Met Ile Arg Ala Phe Asp His Val Leu His Leu Arg Pro Leu Ser
 465                 470                 475                 480
 Arg Leu Gln Ala Ala Cys His Arg Leu Lys Leu Trp Pro Glu Leu Gln
                 485                 490                 495    
 Asp Asn Gly Gly Asp Tyr Val Ser Ala Ala Leu Gly Pro Leu Thr Thr
             500                 505                 510        
 Leu Leu Glu Gln Gly Leu Gly Ala Arg Leu Asn Leu Leu Ala His Ser
         515                 520                 525            
 Arg Pro Pro Val Pro Glu Trp Asp Ile Ser Gln Asp Pro Pro Lys His
     530                 535                 540                
 Lys Asp Ser Gly Thr Leu Thr Leu Gly Leu Leu Leu Arg Pro Glu Gly
 545                 550                 555                 560
 Leu Thr Ser Val Leu Glu Leu Gly Pro Glu Ala Asp Gln Pro Glu Ala
                 565                 570                 575    
 Ala Lys Phe Arg Gln Phe Trp Gly Ser Arg Ser Glu Leu Arg Arg Phe
             580                 585                 590        
 Gln Asp Gly Ala Ile Arg Glu Ala Val Val Trp Glu Ala Ala Ser Met
         595                 600                 605            
 Ser Gln Lys Arg Leu Ile Pro His Gln Val Val Thr His Leu Leu Ala
     610                 615                 620                
 Leu His Ala Asp Ile Pro Glu Thr Cys Val His Tyr Val Gly Gly Pro
 625                 630                 635                 640
 Leu Asp Ala Leu Ile Gln Gly Leu Lys Glu Thr Ser Ser Thr Gly Glu
                 645                 650                 655    
 Glu Ala Leu Val Ala Ala Val Arg Cys Tyr Asp Asp Leu Ser Arg Leu
             660                 665                 670        
 Leu Trp Gly Leu Glu Gly Leu Pro Leu Thr Val Ser Ala Val Gln Gly
         675                 680                 685            
 Ala His Pro Val Leu Arg Tyr Thr Glu Val Phe Pro Pro Thr Pro Val
     690                 695                 700                
 Arg Pro Ala Phe Ser Phe Tyr Glu Thr Leu Arg Glu Arg Ser Ser Leu
 705                 710                 715                 720
 Leu Pro Gly Ser Ile Ser Leu Ser Gly Tyr Val Glu Pro Met Asn Val
                 725                 730                 735    
 Val Cys His Leu Glu Gly Ser Gly Gln Trp Gln Gln Glu Ala Glu Ala
             740                 745                 750        
 Trp Arg Gly Arg Val Pro Gln Cys Ala Trp Lys Val
         755                 760                



      <210> 1425
      <211> 200
      <212> PRT
      <213> Homo sapiens


      <400> 1425
 Met Gly His Ala Gly Leu Gly Leu Ala Met Glu Ala Glu Arg Ser Glu
   1               5                  10                  15    
 Met Trp Lys Gly Glu Arg Lys Asn Phe Gln Gly Gly Glu Asp Met Gly
              20                  25                  30        
 Thr Cys Trp Val Arg Ser Pro Val Val His Ser Val Leu Val Met Gly
          35                  40                  45            
 Tyr Gly Gly Leu Thr Ser Leu Phe Asn Leu Val Val Leu Ala Trp Ala
      50                  55                  60                
 Leu Trp Thr Leu Arg Arg Leu Arg Glu Arg Ala Asp Ala Pro Ser Val
  65                  70                  75                  80
 Arg Ala Cys His Asp Thr Val Thr Val Leu Gly Leu Thr Val Leu Leu
                  85                  90                  95    
 Gly Thr Thr Trp Ala Leu Ala Phe Phe Ser Phe Gly Val Phe Leu Leu
             100                 105                 110        
 Pro Gln Leu Phe Leu Phe Thr Ile Leu Asn Ser Leu Tyr Gly Lys Gly
         115                 120                 125            
 Gly Gly Thr Val Ser Lys Lys Ser Asp Asp Thr Thr Val Phe Leu Lys
     130                 135                 140                
 Asn Asp Glu Thr Ala Trp Gly Lys Leu Leu Cys Leu Pro Tyr Ser Gly
 145                 150                 155                 160
 Phe Phe Phe Ser Lys Pro Ile Ser Ser Leu Ala Met Ile Arg Gly Asn
                 165                 170                 175    
 Thr Pro Ala Leu Val Gly Gly Tyr Asp Ile Leu Ala Ile Tyr Glu Val
             180                 185                 190        
 Glu His Phe Gln Gln Glu Gln Val
         195                 200



      <210> 1426
      <211> 796
      <212> PRT
      <213> Homo sapiens


      <400> 1426
 Met Glu Ala Ala Leu Leu Glu Trp Gly Thr Leu Ala Met Val Ser Met
   1               5                  10                  15    
 His Met Arg Lys Leu Glu Val Leu Val Asn Phe Met Arg Ala Gln Arg
              20                  25                  30        
 Ala Ser Gln Gly Gly Gln Ser Leu Pro Ser Val Arg Gln Thr Ser Leu
          35                  40                  45            
 Leu Ser Ala Leu Leu Val Met Ala Val Thr His Arg Asp Ile Ala Gln
      50                  55                  60                
 Leu Leu Glu Gln His Gln Val Ser Asp Leu Thr Asp Phe His Trp Val
  65                  70                  75                  80
 Arg Gln Leu Lys Tyr His Leu Gly Ser Pro His Ile Ile Pro Lys Ser
                  85                  90                  95    
 Pro Leu Gln Ser Leu Lys Thr Ile Ala Ser Ser Glu Pro Ser Leu Ser
             100                 105                 110        
 Pro Ala Ala Cys Trp Ile Asp Val Leu Gly Arg Ser Phe Leu Tyr Asn
         115                 120                 125            
 Tyr Glu Tyr Leu Gly Pro Arg Leu Gly Pro Leu Pro Ser Leu Leu Pro
     130                 135                 140                
 Glu Arg Pro Ala Leu Val Leu Leu Leu Ala Leu Glu Glu Val Ala Cys
 145                 150                 155                 160
 Gly Thr Val Leu Gly Pro Asn Gly Val Gly Lys Arg Ala Ile Val Asn
                 165                 170                 175    
 Ser Leu Ala Gln Ala Leu Gly Arg Gln Leu Val Met Leu Pro Cys Ser
             180                 185                 190        
 Pro Gln Ile Glu Ala Gln Cys Leu Ser Asn Tyr Leu Asn Gly Ala Leu
         195                 200                 205            
 Gln Gly Gly Ala Trp Leu Leu Leu Glu Lys Val His Gln Leu Pro Pro
     210                 215                 220                
 Gly Leu Leu Ser Ala Leu Gly Gln Arg Leu Gly Glu Leu His His Leu
 225                 230                 235                 240
 Tyr Ala Pro Leu Tyr Gln Glu Ala Ser Arg Asn Thr Ser Thr Ile Asp
                 245                 250                 255    
 Pro Thr Gln Pro Gln Leu Leu Gly Ser Ser Phe Phe Glu Lys His His
             260                 265                 270        
 Val Ser Val Arg Leu Gly Tyr Gly Cys Leu Leu Val Leu Arg Ala Leu
         275                 280                 285            
 Ser Ser Ala Val Pro Ala Asn Leu His Leu Leu Leu Arg Pro Val Ala
     290                 295                 300                
 Leu Ala Leu Pro Asp Leu Arg Gln Val Ala Glu Leu Thr Leu Leu Gly
 305                 310                 315                 320
 Ala Gly Met Arg Asp Ala Phe Gln Met Ala Thr Arg Leu Ser Lys Phe
                 325                 330                 335    
 Phe Ser Leu Glu Arg Glu Leu Val Ser Gly Pro Leu Pro Cys Arg Leu
             340                 345                 350        
 Pro Leu Leu Lys Gln Ile Leu Glu Asp Thr Ile Arg Thr Leu Asn Val
         355                 360                 365            
 Thr Lys Glu Glu Pro Lys Cys Gln Lys Pro Arg Ser Leu Ala Ala Ile
     370                 375                 380                
 Glu Glu Ala Ala Leu Leu His Ala Leu Leu Arg Ser Pro Leu Phe Ser
 385                 390                 395                 400
 Ile Leu Asn Gly Leu His Leu His Asn Leu Arg Gly Leu Leu Cys Ala
                 405                 410                 415    
 Leu Phe Pro Ser Ala Ser Gln Val Leu Ala Glu Pro Met Thr Tyr Lys
             420                 425                 430        
 Leu Met Lys Pro Leu Val Val Glu Glu Leu Gln Gln Val Gly Leu Asp
         435                 440                 445            
 Pro Ser Pro Asp Ile Leu Gly Ser Leu Glu Gln Leu Ser Gln Ala Leu
     450                 455                 460                
 Ser Arg Ala Ser Gly Ile Leu Leu Leu Gly Pro Ala Gly Ser Gly Lys
 465                 470                 475                 480
 Thr Thr Cys Trp His Ser Leu Phe Lys Ile Gln Asn Arg Leu Ala Ala
                 485                 490                 495    
 Met Glu Asp Thr Ser Thr Gln Gly Cys Gln Pro Val Glu Ile Thr His
             500                 505                 510        
 Leu Tyr Pro Ser Gly Leu Ser Pro Gln Glu Phe Leu Gly Trp Leu Glu
         515                 520                 525            
 Gly Ser Cys Trp His His Gly Ile Phe Pro Lys Val Leu Arg Ala Ala
     530                 535                 540                
 Gly Gln Cys Asn Asn Met Gly Gln Lys Arg Gln Thr Glu Glu Ser Ile
 545                 550                 555                 560
 Gly Ile Gln His Trp Ile Ile Cys Asp Gly Ala Ser Asn Gly Ala Trp
                 565                 570                 575    
 Leu Asp Ser Ile Thr Cys Leu Leu Ser Glu Leu Pro Gln Leu Ser Leu
             580                 585                 590        
 Pro Ser Gly Gln Gln Ile Ala Arg Pro Pro Gly Thr Phe Leu Leu Met
         595                 600                 605            
 Glu Val Ala Asp Thr Thr Gly Ile Ser Pro Thr Val Val Gly Cys Cys
     610                 615                 620                
 Ala Leu Val Trp Cys Gly Gly Glu Gln Thr Trp Gln Cys Ile Leu Ser
 625                 630                 635                 640
 Ala Leu Met Ala Ser Leu Pro Tyr Glu Tyr Arg Leu Gln His Arg Thr
                 645                 650                 655    
 Val Ala Glu Leu Asn His Met Ala Glu Val Leu Val Pro Ala Thr Leu
             660                 665                 670        
 Arg Phe Leu Thr Cys Gln Gly Val Ser Ser Leu Leu Gln Val His Gly
         675                 680                 685            
 Gln Gln Ala Val Cys Ala Gly Val Ala Glu Val Thr Ser Met Ala Arg
     690                 695                 700                
 Ile Leu His Ser Leu Leu Asp Leu His Leu Arg Leu Lys Glu Glu Lys
 705                 710                 715                 720
 Ala Pro Gly Pro Glu Asp Leu Ser Tyr Ser Asp Pro Val Ala Gln Ser
                 725                 730                 735    
 Phe Arg Ser Ser Lys Ser Ser Phe Leu Asn Arg Ser Gln Val Asp Ser
             740                 745                 750        
 Asp Asp Val Pro Asp Lys Cys Arg Glu His Leu Leu Ala Val Ser Ser
         755                 760                 765            
 Phe Leu Phe Ala Leu Ile Trp Gly Phe Gly Ala His Leu Pro Ser Arg
     770                 775                 780                
 Tyr Leu Pro Gly Trp Gly Met Gly Asp Ala Glu Gly
 785                 790                 795    



      <210> 1427
      <211> 565
      <212> PRT
      <213> Homo sapiens


      <400> 1427
 Met Thr Gly Leu Val Asp Leu Thr Leu Ser Arg Asn Ala Ile Thr Arg
   1               5                  10                  15    
 Ile Gly Ala Arg Ala Phe Gly Asp Leu Glu Ser Leu Arg Ser Leu His
              20                  25                  30        
 Leu Asp Gly Asn Arg Leu Val Glu Leu Gly Thr Gly Ser Leu Arg Gly
          35                  40                  45            
 Pro Val Asn Leu Gln His Leu Ile Leu Ser Gly Asn Gln Leu Gly Arg
      50                  55                  60                
 Ile Ala Pro Gly Ala Phe Asp Asp Phe Leu Glu Ser Leu Glu Asp Leu
  65                  70                  75                  80
 Asp Leu Ser Tyr Asn Asn Leu Arg Gln Val Pro Trp Ala Gly Ile Gly
                  85                  90                  95    
 Ala Met Pro Ala Leu His Thr Leu Asn Leu Asp His Asn Leu Ile Asp
             100                 105                 110        
 Ala Leu Pro Pro Gly Ala Phe Ala Gln Leu Gly Gln Leu Ser Arg Leu
         115                 120                 125            
 Asp Leu Thr Ser Asn Arg Leu Ala Thr Leu Ala Pro Asp Pro Leu Phe
     130                 135                 140                
 Ser Arg Gly Arg Asp Ala Glu Ala Ser Pro Ala Pro Leu Val Leu Ser
 145                 150                 155                 160
 Phe Ser Gly Asn Pro Leu His Cys Asn Cys Glu Leu Leu Trp Leu Arg
                 165                 170                 175    
 Arg Leu Ala Arg Pro Asp Asp Leu Glu Thr Cys Ala Ser Pro Pro Gly
             180                 185                 190        
 Leu Ala Gly Arg Tyr Phe Trp Ala Val Pro Glu Gly Glu Phe Ser Cys
         195                 200                 205            
 Glu Pro Pro Leu Ile Ala Arg His Thr Gln Arg Leu Trp Val Leu Glu
     210                 215                 220                
 Gly Gln Arg Ala Thr Leu Arg Cys Arg Ala Leu Gly Asp Pro Ala Pro
 225                 230                 235                 240
 Thr Met His Trp Val Gly Pro Asp Asp Arg Leu Val Gly Asn Ser Ser
                 245                 250                 255    
 Arg Ala Arg Ala Phe Pro Asn Gly Thr Leu Glu Ile Gly Val Thr Gly
             260                 265                 270        
 Ala Gly Asp Ala Gly Gly Tyr Thr Cys Ile Ala Thr Asn Pro Ala Gly
         275                 280                 285            
 Glu Ala Thr Ala Arg Val Glu Leu Arg Val Leu Ala Leu Pro His Gly
     290                 295                 300                
 Gly Asn Ser Ser Ala Glu Gly Gly Arg Pro Gly Pro Ser Asp Ile Ala
 305                 310                 315                 320
 Ala Ser Ala Arg Thr Ala Ala Glu Gly Glu Gly Thr Leu Glu Ser Glu
                 325                 330                 335    
 Pro Ala Val Gln Val Thr Glu Val Thr Ala Thr Ser Gly Leu Val Ser
             340                 345                 350        
 Trp Gly Pro Gly Arg Pro Ala Asp Pro Val Trp Met Phe Gln Ile Gln
         355                 360                 365            
 Tyr Asn Ser Ser Glu Asp Glu Thr Leu Ile Tyr Arg Ile Val Pro Ala
     370                 375                 380                
 Ser Ser His His Phe Leu Leu Lys His Leu Val Pro Gly Ala Asp Tyr
 385                 390                 395                 400
 Asp Leu Cys Leu Leu Ala Leu Ser Pro Ala Ala Gly Pro Ser Asp Leu
                 405                 410                 415    
 Thr Ala Thr Arg Leu Leu Gly Cys Ala His Phe Ser Thr Leu Pro Ala
             420                 425                 430        
 Ser Pro Leu Cys His Ala Leu Gln Ala His Val Leu Gly Gly Thr Leu
         435                 440                 445            
 Thr Val Ala Val Gly Gly Val Leu Val Ala Ala Leu Leu Val Phe Thr
     450                 455                 460                
 Val Ala Leu Leu Val Arg Gly Arg Gly Ala Gly Asn Gly Arg Leu Pro
 465                 470                 475                 480
 Leu Lys Leu Ser His Val Gln Ser Gln Thr Asn Gly Gly Pro Ser Pro
                 485                 490                 495    
 Thr Pro Lys Ala His Pro Pro Arg Ser Pro Pro Pro Arg Pro Gln Arg
             500                 505                 510        
 Ser Cys Ser Leu Asp Leu Gly Asp Ala Gly Cys Tyr Gly Tyr Ala Arg
         515                 520                 525            
 Arg Leu Gly Gly Ala Trp Ala Arg Arg Ser His Ser Val His Gly Gly
     530                 535                 540                
 Leu Leu Gly Ala Gly Cys Arg Gly Val Gly Gly Ser Ala Glu Arg Leu
 545                 550                 555                 560
 Glu Glu Ser Val Val
                 565



      <210> 1428
      <211> 658
      <212> PRT
      <213> Homo sapiens


      <400> 1428
 Met Thr Asp Glu Lys Lys Lys Arg Lys Ser Asn Gln Leu Lys Glu Ile
   1               5                  10                  15    
 Arg Arg Thr Glu Leu Lys Arg Tyr Tyr Ser Ile Val Glu Leu Leu Met
              20                  25                  30        
 Val Leu Cys Cys Gln Pro Pro Glu Pro Pro Ser Asp Ala Leu Met Ile
          35                  40                  45            
 Glu Ile Asp Gly Gly Glu Ser Trp Ser Phe Met Asp Leu Phe Ser Asn
      50                  55                  60                
 Ser Asp Arg Gln Thr Asn Asp Pro Leu Lys Met Ser Met Ser Tyr Phe
  65                  70                  75                  80
 Pro Lys Pro Val Arg Leu His Ser Lys Asp Asp Asn Gln Asn Lys Thr
                  85                  90                  95    
 His Asp Lys Lys Glu Lys Lys Met Val Val Gln Lys Pro His Gly Thr
             100                 105                 110        
 Met Glu Tyr Thr Val Leu Phe Val Pro Asp Ala Asn Ser Pro Ser Ser
         115                 120                 125            
 Thr Leu Arg Leu Ser Ser Ser Ser Pro Gly Ala Thr Val Ser Pro Ser
     130                 135                 140                
 Ser Ser Asp Ala Glu Tyr Asp Lys Leu Pro Asp Ala Asp Leu Ala Arg
 145                 150                 155                 160
 Lys Ala Leu Lys Pro Ile Glu Arg Val Leu Ser Ser Thr Ser Glu Glu
                 165                 170                 175    
 Asp Glu Pro Gly Val Val Lys Phe Leu Lys Met Asn Cys Arg Tyr Phe
             180                 185                 190        
 Thr Asp Gly Lys Gly Val Val Gly Gly Val Met Ile Val Thr Pro Asn
         195                 200                 205            
 Asn Ile Met Phe Asp Pro His Lys Ser Asp Pro Leu Val Ile Glu Asn
     210                 215                 220                
 Gly Cys Glu Glu Tyr Gly Leu Ile Cys Pro Met Glu Glu Val Val Ser
 225                 230                 235                 240
 Ile Ala Leu Tyr Asn Asp Ile Ser His Met Lys Ile Lys Asp Ala Leu
                 245                 250                 255    
 Pro Ser Pro Gly Glu Trp Glu Asp Leu Ala Ser Glu Lys Asp Ile Asn
             260                 265                 270        
 Pro Phe Ser Lys Phe Lys Ser Ile Asn Lys Glu Lys Arg Gln Gln Asn
         275                 280                 285            
 Gly Glu Lys Ile Met Thr Ser Asp Ser Arg Pro Ile Val Pro Leu Glu
     290                 295                 300                
 Lys Ser Thr Gly His Thr Pro Thr Lys Pro Ser Gly Ser Ser Val Ser
 305                 310                 315                 320
 Glu Lys Leu Lys Lys Leu Asp Ser Ser Arg Glu Thr Ser His Gly Ser
                 325                 330                 335    
 Pro Thr Val Thr Lys Leu Ser Lys Glu Pro Ser Asp Thr Ser Ser Ala
             340                 345                 350        
 Phe Glu Ser Thr Ala Lys Glu Asn Phe Leu Gly Glu Asp Asp Asp Phe
         355                 360                 365            
 Val Asp Leu Glu Glu Leu Ser Ser Gln Thr Gly Gly Gly Met His Lys
     370                 375                 380                
 Lys Asp Thr Leu Lys Glu Cys Leu Ser Leu Asp Pro Glu Glu Arg Lys
 385                 390                 395                 400
 Lys Ala Glu Ser Gln Ile Asn Asn Ser Ala Val Glu Met Gln Val Gln
                 405                 410                 415    
 Ser Ala Leu Ala Phe Leu Gly Thr Glu Asn Asp Val Glu Leu Lys Gly
             420                 425                 430        
 Ala Leu Asp Leu Glu Thr Cys Glu Lys Gln Asp Ile Met Pro Glu Val
         435                 440                 445            
 Asp Lys Gln Ser Gly Ser Pro Glu Ser Arg Val Glu Asn Thr Leu Asn
     450                 455                 460                
 Ile His Glu Asp Leu Asp Lys Val Lys Leu Ile Glu Tyr Tyr Leu Thr
 465                 470                 475                 480
 Lys Asn Lys Glu Gly Pro Gln Val Ser Glu Asn Leu Gln Lys Thr Glu
                 485                 490                 495    
 Leu Ser Asp Gly Lys Ser Ile Glu Pro Gly Gly Ile Asp Ile Thr Leu
             500                 505                 510        
 Ser Ser Ser Leu Ser Gln Ala Gly Asp Pro Ile Thr Glu Gly Asn Lys
         515                 520                 525            
 Glu Pro Asp Lys Thr Trp Val Lys Lys Gly Glu Pro Leu Pro Val Lys
     530                 535                 540                
 Leu Asn Ser Ser Thr Glu Ala Asn Val Ile Lys Glu Ala Leu Asp Ser
 545                 550                 555                 560
 Ser Leu Glu Ser Thr Leu Asp Asn Ser Cys Gln Gly Ala Gln Met Asp
                 565                 570                 575    
 Asn Lys Ser Glu Val Gln Leu Trp Leu Leu Lys Arg Ile Gln Val Pro
             580                 585                 590        
 Ile Glu Gly Lys Leu Phe Phe Phe Asn Ala Phe Ile Phe Cys Cys Ile
         595                 600                 605            
 Ile Ala Phe Leu Gln Phe Ala His Val Ile Pro Thr Leu Val His Leu
     610                 615                 620                
 Phe Glu Asn Ser Ile Phe Ser Ile Glu Cys Ile Phe Ala Asp Ser Ile
 625                 630                 635                 640
 Asn Asn Trp Gly Glu Asn Leu Gln Asp Met Val Ser Ile Leu Glu Leu
                 645                 650                 655    
 Gly Leu
        



      <210> 1429
      <211> 374
      <212> PRT
      <213> Homo sapiens


      <400> 1429
 Met Val Leu Ile His Ala Ser Gly Leu Leu Leu Gln Gln Gln Leu Pro
   1               5                  10                  15    
 Gly Ala Cys Ala Ala Lys Gly Pro Ala Arg Thr Pro Ser Lys Ala Leu
              20                  25                  30        
 Ser Leu Pro Gln Lys Lys Glu Asp Ile His Asp Tyr Asn Asp Ile Asp
          35                  40                  45            
 Met Ala Cys Leu Leu Val Leu Asp Asp Lys Leu Val Phe Val Lys Val
      50                  55                  60                
 His Ala Pro Trp Glu Val Leu Cys Thr Tyr Ala Glu Ile Met His Ile
  65                  70                  75                  80
 Lys Leu Pro Leu Lys Pro Asn Asp Leu Lys Asn Arg Ser Ser Ala Phe
                  85                  90                  95    
 Gly Thr Leu Asn Trp Phe Thr Lys Val Leu Ser Val Asp Glu Ser Ile
             100                 105                 110        
 Ile Lys Pro Glu Gln Glu Phe Phe Thr Ala Pro Phe Glu Lys Asn Arg
         115                 120                 125            
 Met Asn Asp Phe Tyr Ile Val Asp Arg Asp Ala Phe Phe Asn Pro Ala
     130                 135                 140                
 Thr Arg Ser Arg Ile Ile Leu Leu Ile Ile Ala Ser Val Ile Gly Ile
 145                 150                 155                 160
 Ile Val Tyr Arg Leu Ser Val Phe Ile Val Phe Ser Ala Lys Leu Pro
                 165                 170                 175    
 Lys Asn Ile Asn Gly Thr Asp Pro Ile Gln Lys Tyr Leu Thr Pro Gln
             180                 185                 190        
 Thr Ala Thr Ser Ile Thr Ala Ser Ile Ile Ser Phe Ile Ile Ile Met
         195                 200                 205            
 Ile Leu Asn Thr Ile Tyr Glu Lys Val Ala Ile Met Ile Thr Asn Phe
     210                 215                 220                
 Gly Lys Ala Met Ile Ile Ala Phe Thr Ser Asp Met Ile Pro Arg Leu
 225                 230                 235                 240
 Val Tyr Tyr Trp Ser Phe Ser Val Pro Pro Tyr Gly Asp His Thr Ser
                 245                 250                 255    
 Tyr Thr Met Glu Gly Tyr Arg Asp Phe Arg Tyr Pro Pro Gly His Pro
             260                 265                 270        
 Gln Glu Tyr Lys His Asn Ile Tyr Tyr Trp His Val Ile Ala Ala Lys
         275                 280                 285            
 Leu Ala Phe Ile Ile Val Met Glu Pro Lys Ile Ser Pro Ile His Ser
     290                 295                 300                
 Ile Ser Leu Leu Ile Met Ala Thr Pro Ser Gln His Cys Ser Gly Gln
 305                 310                 315                 320
 Asn Pro Trp Asn Pro Asn Ala Ile Ser Asn Leu Val Gly Phe Ser Phe
                 325                 330                 335    
 Ile Ser Glu His Phe Arg Pro Ile Val Leu Leu Pro Pro Gly Gln Arg
             340                 345                 350        
 Phe Leu Ile Asp Lys Leu Lys Asn Glu Lys Val Phe Asn Leu Ile Gly
         355                 360                 365            
 Asn Gln Glu Asn Ala Glu
     370                



      <210> 1430
      <211> 113
      <212> PRT
      <213> Homo sapiens


      <400> 1430
 Met Tyr Gly Leu Lys Glu Ile Tyr Gln Val Arg Glu Met Ser Asn Val
   1               5                  10                  15    
 Val Phe Ser Leu Lys Ala Val Met Trp Val Leu Phe Tyr Cys Leu Phe
              20                  25                  30        
 Val Cys Cys Cys Ile Leu Phe Ser Leu Leu Phe Ala Leu Gln Asn Ala
          35                  40                  45            
 Leu Gly Lys Gly Trp Phe Leu Ser Leu Leu Val Cys Val Phe Phe Phe
      50                  55                  60                
 Phe Phe Leu Lys His Lys Ile Thr Cys His Gly Gly Arg Ala Leu Pro
  65                  70                  75                  80
 Pro Leu Pro Phe Thr Phe Phe Leu Arg Ala Lys Thr Gly Ala Leu Gly
                  85                  90                  95    
 Gly Val Leu Phe Trp Thr Leu Ser Arg Gly Gly Ile Ser Gln Lys Lys
             100                 105                 110        
 Ile
    



      <210> 1431
      <211> 178
      <212> PRT
      <213> Homo sapiens


      <400> 1431
 Met Ser Pro Thr Ala Pro Glu Lys Met Glu Ser Asn Ser Thr Phe Thr
   1               5                  10                  15    
 Ser Phe Glu Asn Thr Thr Val Trp Phe Leu Gly Thr Ile Asn Cys Ile
              20                  25                  30        
 Thr Val Ala Leu Val Phe Ser Lys Gly Lys Pro Phe Arg Gln Pro Thr
          35                  40                  45            
 Tyr Thr Asn Tyr Ile Phe Val Leu Val Leu Ile Ile Gln Leu Gly Val
      50                  55                  60                
 Cys Leu Phe Ile Leu Phe Ala Asp Ile Pro Glu Leu Tyr Arg Arg Leu
  65                  70                  75                  80
 Asp Leu Leu Cys Thr Pro Val Leu Trp Arg Ala Ser Ile Val Ile Met
                  85                  90                  95    
 Leu Ser Leu Asn Phe Ile Val Ser Leu Val Ala Glu Glu Ala Val Ile
             100                 105                 110        
 Glu Asn Arg Ala Leu Trp Met Met Ile Lys Arg Cys Phe Gly Tyr Gln
         115                 120                 125            
 Ser Lys Ser Gln Tyr Arg Ile Trp Gln Arg Asp Leu Ala Asn Asp Pro
     130                 135                 140                
 Ser Trp Pro Pro Leu Asn Gln Thr Ser His Ser Asp Met Pro Glu Cys
 145                 150                 155                 160
 Gly Arg Gly Val Ser Tyr Ser Asn Pro Val Phe Glu Ser Asn Glu Glu
                 165                 170                 175    
 Gln Leu
        



      <210> 1432
      <211> 169
      <212> PRT
      <213> Homo sapiens


      <400> 1432
 Met Ala Ala Gly Arg Leu Leu Leu Tyr Thr Gly Leu Ser Leu Ala Leu
   1               5                  10                  15    
 Cys Ala Leu Gly Met Leu Ala Val Ala Ile Cys Ser Asp His Trp Tyr
              20                  25                  30        
 Glu Thr Asp Ala Arg Lys His Arg Asp Arg Cys Lys Ala Phe Asn Thr
          35                  40                  45            
 Arg Arg Val Asp Pro Gly Phe Ile Tyr Asn Asn Asn Asn Asn Leu Pro
      50                  55                  60                
 Leu Arg Ala Ser Arg Ser Arg Leu Asp Arg Trp Glu Gly Lys Leu Leu
  65                  70                  75                  80
 Arg Ala Arg Asn Arg Arg Gln Leu Phe Ala Met Ser Pro Ala Asp Glu
                  85                  90                  95    
 Cys Ser Arg Gln Tyr Asn Ser Thr Asn Met Gly Leu Trp Arg Lys Cys
             100                 105                 110        
 His Arg Gln Gly Phe Asp Pro Glu Ile Ala Ala Leu Ile Arg Lys Gly
         115                 120                 125            
 Glu Ile Glu Arg Cys Thr Tyr Ile Lys Tyr His Tyr Ser Ser Ala Thr
     130                 135                 140                
 Ile Pro Arg Asn Leu Thr Phe Asn Ile Thr Lys Thr Ile Arg Gln Asp
 145                 150                 155                 160
 Glu Trp His Ala Leu Arg Lys Cys Thr
                 165                



      <210> 1433
      <211> 305
      <212> PRT
      <213> Homo sapiens


      <400> 1433
 Met Ala Ala Gly Arg Leu Leu Leu Tyr Thr Gly Leu Ser Leu Ala Leu
   1               5                  10                  15    
 Cys Ala Leu Gly Met Leu Ala Val Ala Ile Cys Ser Asp His Trp Tyr
              20                  25                  30        
 Glu Thr Asp Ala Arg Lys His Arg Asp Arg Cys Lys Ala Phe Asn Thr
          35                  40                  45            
 Arg Arg Val Asp Pro Gly Phe Ile Tyr Asn Asn Asn Asn Asn Leu Pro
      50                  55                  60                
 Leu Arg Ala Ser Arg Ser Arg Leu Asp Arg Trp Glu Gly Lys Leu Leu
  65                  70                  75                  80
 Arg Ala Arg Asn Arg Arg Gln Leu Phe Ala Met Ser Pro Ala Asp Glu
                  85                  90                  95    
 Cys Ser Arg Gln Tyr Asn Ser Thr Asn Met Gly Leu Trp Arg Lys Cys
             100                 105                 110        
 His Arg Gln Gly Phe Asp Pro Glu Ile Ala Ala Leu Ile Arg Lys Gly
         115                 120                 125            
 Glu Ile Glu Arg Cys Thr Tyr Ile Lys Tyr His Tyr Ser Ser Ala Thr
     130                 135                 140                
 Ile Pro Arg Asn Leu Thr Phe Asn Ile Thr Lys Thr Ile Arg Gln Asp
 145                 150                 155                 160
 Glu Trp His Ala Leu Arg Ile Ala Leu Ser Ala Gln Val Gly Pro Gly
                 165                 170                 175    
 Pro Phe Pro Val Trp His Asn Lys Gly Arg Trp Leu Ile Gly Ser Gly
             180                 185                 190        
 Gly Ser Ala Thr Gly Pro Gly Gln Pro Gly Trp Ala Ile Ser Glu Glu
         195                 200                 205            
 Ala Glu Lys Thr Gly Asp Gly Lys Met Ser Leu Arg Gly Glu Leu Ser
     210                 215                 220                
 Gln Phe Gln Val Leu Lys Arg Glu Leu Asn Met Ala Gly Ser Ile Leu
 225                 230                 235                 240
 Leu Ser Lys Thr Gly Ser Pro Lys Leu Asp Thr Leu Asn Ser His Asp
                 245                 250                 255    
 Glu Arg Ser Asp Phe Ser Val Pro Cys Ser Gln Pro Leu Ile Gln Asp
             260                 265                 270        
 Arg Cys Leu Pro Leu Asp Val Pro Cys Val Gly Leu Tyr Glu Val Gln
         275                 280                 285            
 Lys Pro Asn Gln Gly Thr Ser Ser Val Leu Gly Ala Gly Ile Ile Gln
     290                 295                 300                
 Ser
 305



      <210> 1434
      <211> 109
      <212> PRT
      <213> Homo sapiens


      <400> 1434
 Met Ser Gln Val Gln Gly Arg Gly Pro Thr Trp Ala Val Leu Val Met
   1               5                  10                  15    
 Ser Lys Val Gly Leu Arg Gly Asp Gln Arg Ser Glu Gly Gly Glu Val
              20                  25                  30        
 Leu Asp Pro Leu Arg Gln Ala Leu His Asn Ser Met Gln Ser His Asn
          35                  40                  45            
 Leu Tyr Gln His Pro Gln His Leu Ala Phe His Val Ser Ala Pro Val
      50                  55                  60                
 Trp Pro Pro Arg Cys Asn Lys Leu Ala Val Tyr Leu Asp Leu Cys Leu
  65                  70                  75                  80
 Ile Phe Leu Leu Leu Cys Phe Arg Leu His Ile Arg Phe Phe Leu His
                  85                  90                  95    
 Leu Ala Leu Met Met Gln Arg Phe Pro Arg Lys Trp Arg
             100                 105                



      <210> 1435
      <211> 368
      <212> PRT
      <213> Homo sapiens


      <400> 1435
 Met Ala Ala Ile Gln Arg Glu Asn Leu Phe Asp Pro Gly Asn Thr Gly
   1               5                  10                  15    
 Tyr Ile Ser Thr Gly Lys Phe Arg Ser Leu Leu Glu Ser His Ser Ser
              20                  25                  30        
 Lys Leu Asp Pro His Lys Arg Glu Val Leu Leu Ala Leu Ala Asp Ser
          35                  40                  45            
 His Ala Asp Gly Gln Ile Gly Tyr Gln Asp Phe Val Ser Leu Met Ser
      50                  55                  60                
 Asn Lys Arg Ser Asn Ser Phe Arg Gln Ala Ile Leu Gln Gly Asn Arg
  65                  70                  75                  80
 Arg Leu Ser Ser Lys Ala Leu Leu Glu Glu Lys Gly Leu Ser Leu Ser
                  85                  90                  95    
 Gln Arg Leu Ile Arg His Val Ala Tyr Glu Thr Leu Pro Arg Glu Ile
             100                 105                 110        
 Asp Arg Lys Trp Tyr Tyr Asp Ser Tyr Thr Cys Cys Pro Pro Pro Trp
         115                 120                 125            
 Phe Met Ile Thr Val Thr Leu Leu Glu Val Ala Phe Phe Leu Tyr Asn
     130                 135                 140                
 Trp Val Ser Leu Gly Gln Phe Val Leu Gln Val Thr His Pro Arg Tyr
 145                 150                 155                 160
 Leu Lys Asn Ser Leu Val Tyr His Pro Gln Leu Arg Ala Gln Val Trp
                 165                 170                 175    
 Arg Tyr Leu Thr Tyr Ile Phe Met His Ala Gly Ile Glu His Leu Gly
             180                 185                 190        
 Leu Asn Val Val Leu Gln Leu Leu Val Gly Val Pro Leu Glu Met Val
         195                 200                 205            
 His Gly Ala Thr Arg Ile Gly Leu Val Tyr Met Ala Gly Val Val Ala
     210                 215                 220                
 Gly Ser Leu Ala Val Ser Val Ala Asp Met Thr Ala Pro Val Val Gly
 225                 230                 235                 240
 Ser Ser Gly Gly Val Tyr Ala Leu Val Ser Ala His Leu Ala Asn Ile
                 245                 250                 255    
 Val Met Asn Trp Ser Gly Met Lys Cys Gln Phe Lys Leu Leu Arg Met
             260                 265                 270        
 Ala Val Ala Leu Ile Cys Met Ser Met Glu Phe Gly Arg Ala Val Trp
         275                 280                 285            
 Leu Arg Phe His Pro Ser Ala Tyr Pro Pro Cys Pro His Pro Ser Phe
     290                 295                 300                
 Val Ala His Leu Gly Gly Val Ala Val Gly Ile Thr Leu Gly Val Val
 305                 310                 315                 320
 Val Leu Arg Asn Tyr Glu Gln Arg Leu Gln Asp Gln Ser Leu Trp Trp
                 325                 330                 335    
 Ile Phe Val Ala Met Tyr Thr Val Phe Val Leu Phe Ala Val Phe Trp
             340                 345                 350        
 Asn Ile Phe Ala Tyr Thr Leu Leu Asp Leu Lys Leu Pro Pro Pro Pro
         355                 360                 365            





      <210> 1436
      <211> 106
      <212> PRT
      <213> Homo sapiens


      <400> 1436
 Met Thr Ala Tyr Phe Asn Glu Gln Asp Cys Lys Leu Leu Asn Pro Lys
   1               5                  10                  15    
 Gln Glu Thr Leu Thr His Met Leu Leu Glu Leu Ser Arg Ser Leu Phe
              20                  25                  30        
 Asn Arg Met Asp Phe Glu Asp Ser Gly Met Ala Val Asn Trp Asn His
          35                  40                  45            
 His Leu Pro Pro Pro Ala Ala Lys Thr Val Trp Leu Gly Thr Ser Pro
      50                  55                  60                
 Gly Glu Ser Ser Gly Ala Leu Arg Leu Arg Asp Thr His Lys Cys Pro
  65                  70                  75                  80
 Met Cys Leu Arg Arg Arg Arg Leu Leu Leu Gly Cys Leu Ala Ile Ser
                  85                  90                  95    
 Phe Ser Ile Leu Thr Ala Phe Cys Pro Gly
             100                 105    



      <210> 1437
      <211> 1127
      <212> PRT
      <213> Homo sapiens


      <400> 1437
 Met Val Pro Ala Ala Glu Leu Leu Arg Gly Trp Leu Leu Ser Leu Val
   1               5                  10                  15    
 Arg Gly Leu Leu Pro Cys Leu Pro Pro Gly Ala Arg Thr Ala Glu Gly
              20                  25                  30        
 Pro Ile Met Val Leu Ala Gly Pro Leu Ala Val Ser Leu Leu Leu Pro
          35                  40                  45            
 Ser Leu Thr Leu Leu Val Ser His Leu Ser Ser Ser Gln Asp Val Ser
      50                  55                  60                
 Ser Glu Pro Ser Ser Glu Gln Gln Leu Tyr Ala Leu Ser Lys His Pro
  65                  70                  75                  80
 Thr Val Ala Phe Glu Asp Leu Gln Pro Trp Val Ser Asn Phe Thr Tyr
                  85                  90                  95    
 Pro Gly Ala Arg Asp Phe Ser Gln Leu Ala Leu Asp Pro Ser Gly Asn
             100                 105                 110        
 Gln Leu Ile Val Gly Ala Arg Asn Tyr Leu Phe Arg Leu Ser Leu Ala
         115                 120                 125            
 Asn Val Ser Leu Leu Gln Ala Thr Glu Trp Ala Ser Ser Glu Asp Thr
     130                 135                 140                
 Arg Arg Ser Cys Gln Ser Lys Gly Lys Thr Glu Glu Glu Cys Gln Asn
 145                 150                 155                 160
 Tyr Val Arg Val Leu Ile Val Ala Gly Arg Lys Val Phe Met Cys Gly
                 165                 170                 175    
 Thr Asn Ala Phe Ser Pro Met Cys Thr Ser Arg Gln Val Gly Asn Leu
             180                 185                 190        
 Ser Arg Thr Thr Glu Lys Ile Asn Gly Val Ala Arg Cys Pro Tyr Asp
         195                 200                 205            
 Pro Arg His Asn Ser Thr Ala Val Ile Ser Ser Gln Gly Glu Leu Tyr
     210                 215                 220                
 Ala Ala Thr Val Ile Asp Phe Ser Gly Arg Asp Pro Ala Ile Tyr Arg
 225                 230                 235                 240
 Ser Leu Gly Ser Gly Pro Pro Leu Arg Thr Ala Gln Tyr Asn Ser Lys
                 245                 250                 255    
 Trp Leu Asn Glu Pro Asn Phe Val Ala Ala Tyr Asp Ile Gly Leu Phe
             260                 265                 270        
 Ala Tyr Phe Phe Leu Arg Glu Asn Ala Val Glu His Asp Cys Gly Arg
         275                 280                 285            
 Thr Val Tyr Ser Arg Val Ala Arg Val Cys Lys Asn Asp Val Gly Gly
     290                 295                 300                
 Arg Phe Leu Leu Glu Asp Thr Trp Thr Thr Phe Met Lys Ala Arg Leu
 305                 310                 315                 320
 Asn Cys Ser Arg Pro Gly Glu Val Pro Phe Tyr Tyr Asn Glu Leu Gln
                 325                 330                 335    
 Ser Ala Phe His Leu Pro Glu Gln Asp Leu Ile Tyr Gly Val Phe Thr
             340                 345                 350        
 Thr Asn Val Asn Ser Ile Ala Ala Ser Ala Val Cys Ala Phe Asn Leu
         355                 360                 365            
 Ser Ala Ile Ser Gln Ala Phe Asn Gly Pro Phe Arg Tyr Gln Glu Asn
     370                 375                 380                
 Pro Arg Ala Ala Trp Leu Pro Ile Ala Asn Pro Ile Pro Asn Phe Gln
 385                 390                 395                 400
 Cys Gly Thr Leu Pro Glu Thr Gly Pro Asn Glu Asn Leu Thr Glu Arg
                 405                 410                 415    
 Ser Leu Gln Asp Ala Gln Arg Leu Phe Leu Met Ser Glu Ala Val Gln
             420                 425                 430        
 Pro Val Thr Pro Glu Pro Cys Val Thr Gln Asp Ser Val Arg Phe Ser
         435                 440                 445            
 His Leu Val Val Asp Leu Val Gln Ala Lys Asp Thr Leu Tyr His Val
     450                 455                 460                
 Leu Tyr Ile Gly Thr Glu Ser Gly Thr Ile Leu Lys Ala Leu Ser Thr
 465                 470                 475                 480
 Ala Ser Arg Ser Leu His Gly Cys Tyr Leu Glu Glu Leu His Val Leu
                 485                 490                 495    
 Pro Pro Gly Arg Arg Glu Pro Leu Arg Ser Leu Arg Ile Leu His Ser
             500                 505                 510        
 Ala Arg Ala Leu Phe Val Gly Leu Arg Asp Gly Val Leu Arg Val Pro
         515                 520                 525            
 Leu Glu Arg Cys Ala Ala Tyr Arg Ser Gln Gly Ala Cys Leu Gly Ala
     530                 535                 540                
 Arg Asp Pro Tyr Cys Gly Trp Asp Gly Lys Gln Gln Arg Cys Ser Thr
 545                 550                 555                 560
 Leu Glu Asp Ser Ser Asn Met Ser Leu Trp Thr Gln Asn Ile Thr Ala
                 565                 570                 575    
 Cys Pro Val Arg Asn Val Thr Arg Asp Gly Gly Phe Gly Pro Trp Ser
             580                 585                 590        
 Pro Trp Gln Pro Cys Glu His Leu Asp Gly Asp Asn Ser Gly Ser Cys
         595                 600                 605            
 Leu Cys Arg Ala Arg Ser Cys Asp Ser Pro Arg Pro Arg Cys Gly Gly
     610                 615                 620                
 Leu Asp Cys Leu Gly Pro Ala Ile His Ile Ala Asn Cys Ser Arg Asn
 625                 630                 635                 640
 Gly Ala Trp Thr Pro Trp Ser Ser Trp Ala Leu Cys Ser Thr Ser Cys
                 645                 650                 655    
 Gly Ile Gly Phe Gln Val Arg Gln Arg Ser Cys Ser Asn Pro Ala Pro
             660                 665                 670        
 Arg His Gly Gly Arg Ile Cys Val Gly Lys Ser Arg Glu Glu Arg Phe
         675                 680                 685            
 Cys Asn Glu Asn Thr Pro Cys Pro Val Pro Ile Phe Trp Ala Ser Trp
     690                 695                 700                
 Gly Ser Trp Ser Lys Cys Ser Ser Asn Cys Gly Gly Gly Met Gln Ser
 705                 710                 715                 720
 Arg Arg Arg Ala Cys Glu Asn Gly Asn Ser Cys Leu Gly Cys Gly Val
                 725                 730                 735    
 Glu Phe Lys Thr Cys Asn Pro Glu Gly Cys Pro Glu Val Arg Arg Asn
             740                 745                 750        
 Thr Pro Trp Thr Pro Trp Leu Pro Val Asn Val Thr Gln Gly Gly Ala
         755                 760                 765            
 Arg Gln Glu Gln Arg Phe Arg Phe Thr Cys Arg Ala Pro Leu Ala Asp
     770                 775                 780                
 Pro His Gly Leu Gln Phe Gly Arg Arg Arg Thr Glu Thr Arg Thr Cys
 785                 790                 795                 800
 Pro Ala Asp Gly Ser Gly Ser Cys Asp Thr Asp Ala Leu Val Glu Asp
                 805                 810                 815    
 Leu Leu Arg Ser Gly Ser Thr Ser Pro His Thr Val Ser Gly Gly Trp
             820                 825                 830        
 Ala Ala Trp Gly Pro Trp Ser Ser Cys Ser Arg Asp Cys Glu Leu Gly
         835                 840                 845            
 Phe Arg Val Arg Lys Arg Thr Cys Thr Asn Pro Glu Pro Arg Asn Gly
     850                 855                 860                
 Gly Leu Pro Cys Val Gly Asp Ala Ala Glu Tyr Gln Asp Cys Asn Pro
 865                 870                 875                 880
 Gln Ala Cys Pro Val Arg Gly Ala Trp Ser Cys Trp Thr Ser Trp Ser
                 885                 890                 895    
 Pro Cys Ser Ala Ser Cys Gly Gly Gly His Tyr Gln Arg Thr Arg Ser
             900                 905                 910        
 Cys Thr Ser Pro Ala Pro Ser Pro Gly Glu Asp Ile Cys Leu Gly Leu
         915                 920                 925            
 His Thr Glu Glu Ala Leu Cys Ala Thr Gln Ala Cys Pro Glu Gly Trp
     930                 935                 940                
 Ser Pro Trp Ser Glu Trp Ser Lys Cys Thr Asp Asp Gly Ala Gln Ser
 945                 950                 955                 960
 Arg Ser Arg His Cys Glu Glu Leu Leu Pro Gly Ser Ser Ala Cys Ala
                 965                 970                 975    
 Gly Asn Ser Ser Gln Ser Arg Pro Cys Pro Tyr Ser Glu Ile Pro Val
             980                 985                 990        
 Ile Leu Pro Ala Ser Ser Met Glu Glu Ala Thr Gly Cys Ala Gly Phe
         995                1000                1005            
 Asn Leu Ile His Leu Val Ala Thr Gly Ile Ser Cys Phe Leu Gly Ser
    1010                1015                1020                
 Gly Leu Leu Thr Leu Ala Val Tyr Leu Ser Cys Gln His Cys Gln Arg
1025                1030                1035                1040
 Gln Ser Gln Glu Ser Thr Leu Val His Pro Ala Thr Pro Asn His Leu
                1045                1050                1055    
 His Tyr Lys Gly Gly Gly Thr Pro Lys Asn Glu Lys Tyr Thr Pro Met
            1060                1065                1070        
 Glu Phe Lys Thr Leu Asn Lys Asn Asn Leu Ile Pro Asp Asp Arg Ala
        1075                1080                1085            
 Asn Phe Tyr Pro Leu Gln Gln Thr Asn Val Tyr Thr Thr Thr Tyr Tyr
    1090                1095                1100                
 Pro Ser Pro Leu Asn Lys His Ser Phe Arg Pro Glu Ala Ser Pro Gly
1105                1110                1115                1120
 Gln Arg Cys Phe Pro Asn Ser
                1125        



      <210> 1438
      <211> 970
      <212> PRT
      <213> Homo sapiens


      <400> 1438
 Met Arg Met Gly Gly Ser Asn His Pro Phe Leu Leu Gly Val Val Val
   1               5                  10                  15    
 Lys Leu Glu Gly Asp Thr Val Ser Ala Arg Val Val Pro Trp Tyr Ser
              20                  25                  30        
 Ile Thr Asn Leu Leu Cys Asp Leu Ser Asn Pro Leu Ala Pro Ile Pro
          35                  40                  45            
 Ala Glu Gln Ser Pro Asn Ala Cys Gly Ser His Glu Gly Leu Gly Ile
      50                  55                  60                
 Gln Ile Pro Leu Ser Cys Leu Ala Ser Arg Lys Asp Phe Val Ser Pro
  65                  70                  75                  80
 Glu Val Leu Leu Gly Ala Gly Thr Glu Leu Ser Ser Ala Asp Gly Pro
                  85                  90                  95    
 Gly Ala Gly Met Ala Asp Ser Ser Glu Gly Pro Arg Ala Gly Pro Gly
             100                 105                 110        
 Glu Val Ala Glu Leu Pro Gly Asp Glu Ser Gly Thr Pro Gly Gly Glu
         115                 120                 125            
 Ala Phe Pro Leu Ser Ser Leu Ala Asn Leu Phe Glu Gly Glu Asp Gly
     130                 135                 140                
 Ser Leu Ser Pro Ser Pro Ala Asp Ala Ser Arg Pro Ala Gly Pro Gly
 145                 150                 155                 160
 Asp Gly Arg Pro Asn Leu Arg Met Lys Phe Gln Gly Ala Phe Arg Lys
                 165                 170                 175    
 Gly Val Pro Asn Pro Ile Asp Leu Leu Glu Ser Thr Leu Tyr Glu Ser
             180                 185                 190        
 Ser Val Val Pro Gly Pro Lys Lys Ala Pro Met Asp Ser Leu Phe Asp
         195                 200                 205            
 Tyr Gly Thr Tyr Arg His His Ser Ser Asp Asn Lys Arg Trp Arg Lys
     210                 215                 220                
 Lys Ile Ile Glu Lys Gln Pro Gln Ser Pro Lys Ala Pro Ala Pro Gln
 225                 230                 235                 240
 Pro Pro Pro Ile Leu Lys Val Phe Asn Arg Pro Ile Leu Phe Asp Ile
                 245                 250                 255    
 Val Ser Arg Gly Ser Thr Ala Asp Leu Asp Gly Leu Leu Pro Phe Leu
             260                 265                 270        
 Leu Thr His Lys Lys Arg Leu Thr Asp Glu Glu Phe Arg Glu Pro Ser
         275                 280                 285            
 Thr Gly Lys Thr Cys Leu Pro Lys Ala Leu Leu Asn Leu Ser Asn Gly
     290                 295                 300                
 Arg Asn Asp Thr Ile Pro Val Leu Leu Asp Ile Ala Glu Arg Thr Gly
 305                 310                 315                 320
 Asn Met Arg Glu Phe Ile Asn Ser Pro Phe Arg Asp Ile Tyr Tyr Arg
                 325                 330                 335    
 Gly Gln Thr Ala Leu His Ile Ala Ile Glu Arg Arg Cys Lys His Tyr
             340                 345                 350        
 Val Glu Leu Leu Val Ala Gln Gly Ala Asp Val His Ala Gln Ala Arg
         355                 360                 365            
 Gly Arg Phe Phe Gln Pro Lys Asp Glu Gly Gly Tyr Phe Tyr Phe Gly
     370                 375                 380                
 Glu Leu Pro Leu Ser Leu Ala Ala Cys Thr Asn Gln Pro His Ile Val
 385                 390                 395                 400
 Asn Tyr Leu Thr Glu Asn Pro His Lys Lys Ala Asp Met Arg Arg Gln
                 405                 410                 415    
 Asp Ser Arg Gly Asn Thr Val Leu His Ala Leu Val Ala Ile Ala Asp
             420                 425                 430        
 Asn Thr Arg Glu Asn Thr Lys Phe Val Thr Lys Met Tyr Asp Leu Leu
         435                 440                 445            
 Leu Leu Lys Cys Ala Arg Leu Phe Pro Asp Ser Asn Leu Glu Ala Val
     450                 455                 460                
 Leu Asn Asn Asp Gly Leu Ser Pro Leu Met Met Ala Ala Lys Thr Gly
 465                 470                 475                 480
 Lys Ile Gly Val Phe Gln His Ile Ile Arg Arg Glu Val Thr Asp Glu
                 485                 490                 495    
 Asp Thr Arg His Leu Ser Arg Lys Phe Lys Asp Trp Ala Tyr Gly Pro
             500                 505                 510        
 Val Tyr Ser Ser Leu Tyr Asp Leu Ser Ser Leu Asp Thr Cys Gly Glu
         515                 520                 525            
 Glu Ala Ser Val Leu Glu Ile Leu Val Tyr Asn Ser Lys Ile Glu Asn
     530                 535                 540                
 Arg His Glu Met Leu Ala Val Glu Pro Ile Asn Glu Leu Leu Arg Asp
 545                 550                 555                 560
 Lys Trp Arg Lys Phe Gly Ala Val Ser Phe Tyr Ile Asn Val Val Ser
                 565                 570                 575    
 Tyr Leu Cys Ala Met Val Ile Phe Thr Leu Thr Ala Tyr Tyr Gln Pro
             580                 585                 590        
 Leu Glu Gly Thr Pro Pro Tyr Pro Tyr Arg Thr Thr Val Asp Tyr Leu
         595                 600                 605            
 Arg Leu Ala Gly Glu Val Ile Thr Leu Phe Thr Gly Val Leu Phe Phe
     610                 615                 620                
 Phe Thr Asn Ile Lys Asp Leu Phe Met Lys Lys Cys Pro Gly Val Asn
 625                 630                 635                 640
 Ser Leu Phe Ile Asp Gly Ser Phe Gln Leu Leu Tyr Phe Ile Tyr Ser
                 645                 650                 655    
 Val Leu Val Ile Val Ser Ala Ala Leu Tyr Leu Ala Gly Ile Glu Ala
             660                 665                 670        
 Tyr Leu Ala Val Met Val Phe Ala Leu Val Leu Gly Trp Met Asn Ala
         675                 680                 685            
 Leu Tyr Phe Thr Arg Gly Leu Lys Leu Thr Gly Thr Tyr Ser Ile Met
     690                 695                 700                
 Ile Gln Lys Ile Leu Phe Lys Asp Leu Phe Arg Phe Leu Leu Val Tyr
 705                 710                 715                 720
 Leu Leu Phe Met Ile Gly Tyr Ala Ser Ala Leu Val Ser Leu Leu Asn
                 725                 730                 735    
 Pro Cys Ala Asn Met Lys Val Cys Asn Glu Asp Gln Thr Asn Cys Thr
             740                 745                 750        
 Val Pro Thr Tyr Pro Ser Cys Arg Asp Ser Glu Thr Phe Ser Thr Phe
         755                 760                 765            
 Leu Leu Asp Leu Phe Lys Leu Thr Ile Gly Met Gly Asp Leu Glu Met
     770                 775                 780                
 Leu Ser Ser Thr Lys Tyr Pro Val Val Phe Ile Ile Leu Leu Val Thr
 785                 790                 795                 800
 Tyr Ile Ile Leu Thr Phe Val Leu Leu Leu Asn Met Leu Ile Ala Leu
                 805                 810                 815    
 Met Gly Glu Thr Val Gly Gln Val Ser Lys Glu Ser Lys His Ile Trp
             820                 825                 830        
 Lys Leu Gln Trp Ala Thr Thr Ile Leu Asp Ile Glu Arg Ser Phe Pro
         835                 840                 845            
 Val Phe Leu Arg Lys Ala Phe Arg Ser Gly Glu Met Val Thr Val Gly
     850                 855                 860                
 Lys Ser Ser Asp Gly Thr Pro Asp Arg Arg Trp Cys Phe Arg Val Asn
 865                 870                 875                 880
 Glu Val Asn Trp Ser His Trp Asn Gln Asn Leu Gly Ile Ile Asn Glu
                 885                 890                 895    
 Asp Pro Gly Lys Asn Glu Thr Tyr Gln Tyr Tyr Gly Phe Ser His Thr
             900                 905                 910        
 Val Gly Arg Leu Arg Arg Asp Arg Trp Ser Ser Val Val Pro Arg Val
         915                 920                 925            
 Val Glu Leu Asn Lys Asn Ser Asn Pro Asp Glu Val Val Val Pro Leu
     930                 935                 940                
 Asp Ser Met Gly Asn Pro Arg Cys Asp Gly His Gln Gln Gly Tyr Pro
 945                 950                 955                 960
 Arg Lys Trp Arg Thr Asp Asp Ala Pro Leu
                 965                 970



      <210> 1439
      <211> 1051
      <212> PRT
      <213> Homo sapiens


      <400> 1439
 Met Arg Met Gly Gly Ser Asn His Pro Phe Leu Leu Gly Val Val Val
   1               5                  10                  15    
 Lys Leu Glu Gly Asp Thr Val Ser Ala Arg Val Val Pro Trp Tyr Ser
              20                  25                  30        
 Ile Thr Asn Leu Leu Cys Asp Leu Ser Asn Pro Leu Ala Pro Ile Pro
          35                  40                  45            
 Ala Glu Gln Ser Pro Asn Ala Cys Gly Ser His Glu Gly Leu Gly Ile
      50                  55                  60                
 Gln Ile Pro Leu Ser Cys Leu Ala Ser Arg Lys Asp Phe Val Ser Pro
  65                  70                  75                  80
 Glu Val Leu Leu Gly Ala Gly Thr Glu Leu Ser Ser Ala Asp Gly Pro
                  85                  90                  95    
 Gly Ala Gly Met Ala Asp Ser Ser Glu Gly Pro Arg Ala Gly Pro Gly
             100                 105                 110        
 Glu Val Ala Glu Leu Pro Gly Asp Glu Ser Gly Thr Pro Gly Gly Glu
         115                 120                 125            
 Ala Phe Pro Leu Ser Ser Leu Ala Asn Leu Phe Glu Gly Glu Asp Gly
     130                 135                 140                
 Ser Leu Ser Pro Ser Pro Ala Asp Ala Ser Arg Pro Ala Gly Pro Gly
 145                 150                 155                 160
 Asp Gly Arg Pro Asn Leu Arg Met Lys Phe Gln Gly Ala Phe Arg Lys
                 165                 170                 175    
 Gly Val Pro Asn Pro Ile Asp Leu Leu Glu Ser Thr Leu Tyr Glu Ser
             180                 185                 190        
 Ser Val Val Pro Gly Pro Lys Lys Ala Pro Met Asp Ser Leu Phe Asp
         195                 200                 205            
 Tyr Gly Thr Tyr Arg His His Ser Ser Asp Asn Lys Arg Trp Arg Lys
     210                 215                 220                
 Lys Ile Ile Glu Lys Gln Pro Gln Ser Pro Lys Ala Pro Ala Pro Gln
 225                 230                 235                 240
 Pro Pro Pro Ile Leu Lys Val Phe Asn Arg Pro Ile Leu Phe Asp Ile
                 245                 250                 255    
 Val Ser Arg Gly Ser Thr Ala Asp Leu Asp Gly Leu Leu Pro Phe Leu
             260                 265                 270        
 Leu Thr His Lys Lys Arg Leu Thr Asp Glu Glu Phe Arg Glu Pro Ser
         275                 280                 285            
 Thr Gly Lys Thr Cys Leu Pro Lys Ala Leu Leu Asn Leu Ser Asn Gly
     290                 295                 300                
 Arg Asn Asp Thr Ile Pro Val Leu Leu Asp Ile Ala Glu Arg Thr Gly
 305                 310                 315                 320
 Asn Met Arg Glu Phe Ile Asn Ser Pro Phe Arg Asp Ile Tyr Tyr Arg
                 325                 330                 335    
 Gly Gly Ala Pro Gly Trp Ala Gly Val Pro Arg Gly Leu Met Glu Thr
             340                 345                 350        
 Leu Ser Phe Ala Cys Leu Thr Pro Glu Thr Phe Asp Leu Gly Leu Ser
         355                 360                 365            
 Ala Ser Met Tyr Pro Gly Pro Asp Lys Trp Met Asp Gly Trp Met Asp
     370                 375                 380                
 Gly Trp Met His Gly Cys Met Asp Arg Trp Met Asp Glu Gly Thr Gln
 385                 390                 395                 400
 Ala Trp Leu Gly Leu Cys Ser Ala Arg Thr Leu Asp Asp Arg Pro Leu
                 405                 410                 415    
 Pro Pro Gln Thr Ala Leu His Ile Ala Ile Glu Arg Arg Cys Lys His
             420                 425                 430        
 Tyr Val Glu Leu Leu Val Ala Gln Gly Ala Asp Val His Ala Gln Ala
         435                 440                 445            
 Arg Gly Arg Phe Phe Gln Pro Lys Asp Glu Gly Gly Tyr Phe Tyr Phe
     450                 455                 460                
 Gly Glu Leu Pro Leu Ser Leu Ala Ala Cys Thr Asn Gln Pro His Ile
 465                 470                 475                 480
 Val Asn Tyr Leu Thr Glu Asn Pro His Lys Lys Ala Asp Met Arg Arg
                 485                 490                 495    
 Gln Asp Ser Arg Gly Asn Thr Val Leu His Ala Leu Val Ala Ile Ala
             500                 505                 510        
 Asp Asn Thr Arg Glu Asn Thr Lys Phe Val Thr Lys Met Tyr Asp Leu
         515                 520                 525            
 Leu Leu Leu Lys Cys Ala Arg Leu Phe Pro Asp Ser Asn Leu Glu Ala
     530                 535                 540                
 Val Leu Asn Asn Asp Gly Leu Ser Pro Leu Met Met Ala Ala Lys Thr
 545                 550                 555                 560
 Gly Lys Ile Gly Val Phe Gln His Ile Ile Arg Arg Glu Val Thr Asp
                 565                 570                 575    
 Glu Asp Thr Arg His Leu Ser Arg Lys Phe Lys Asp Trp Ala Tyr Gly
             580                 585                 590        
 Pro Val Tyr Ser Ser Leu Tyr Asp Leu Ser Ser Leu Asp Thr Cys Gly
         595                 600                 605            
 Glu Glu Ala Ser Val Leu Glu Ile Leu Val Tyr Asn Ser Lys Ile Glu
     610                 615                 620                
 Asn Arg His Glu Met Leu Ala Val Glu Pro Ile Asn Glu Leu Leu Arg
 625                 630                 635                 640
 Asp Lys Trp Arg Lys Phe Gly Ala Val Ser Phe Tyr Ile Asn Val Val
                 645                 650                 655    
 Ser Tyr Leu Cys Ala Met Val Ile Phe Thr Leu Thr Ala Tyr Tyr Gln
             660                 665                 670        
 Pro Leu Glu Gly Thr Pro Pro Tyr Pro Tyr Arg Thr Thr Val Asp Tyr
         675                 680                 685            
 Leu Arg Leu Ala Gly Glu Val Ile Thr Leu Phe Thr Gly Val Leu Phe
     690                 695                 700                
 Phe Phe Thr Asn Ile Lys Asp Leu Phe Met Lys Lys Cys Pro Gly Val
 705                 710                 715                 720
 Asn Ser Leu Phe Ile Asp Gly Ser Phe Gln Leu Leu Tyr Phe Ile Tyr
                 725                 730                 735    
 Ser Val Leu Val Ile Val Ser Ala Ala Leu Tyr Leu Ala Gly Ile Glu
             740                 745                 750        
 Ala Tyr Leu Ala Val Met Val Phe Ala Leu Val Leu Gly Trp Met Asn
         755                 760                 765            
 Ala Leu Tyr Phe Thr Arg Gly Leu Lys Leu Thr Gly Thr Tyr Ser Ile
     770                 775                 780                
 Met Ile Gln Lys Ile Leu Phe Lys Asp Leu Phe Arg Phe Leu Leu Val
 785                 790                 795                 800
 Tyr Leu Leu Phe Met Ile Gly Tyr Ala Ser Ala Leu Val Ser Leu Leu
                 805                 810                 815    
 Asn Pro Cys Ala Asn Met Lys Val Cys Asn Glu Asp Gln Thr Asn Cys
             820                 825                 830        
 Thr Val Pro Thr Tyr Pro Ser Cys Arg Asp Ser Glu Thr Phe Ser Thr
         835                 840                 845            
 Phe Leu Leu Asp Leu Phe Lys Leu Thr Ile Gly Met Gly Asp Leu Glu
     850                 855                 860                
 Met Leu Ser Ser Thr Lys Tyr Pro Val Val Phe Ile Ile Leu Leu Val
 865                 870                 875                 880
 Thr Tyr Ile Ile Leu Thr Phe Val Leu Leu Leu Asn Met Leu Ile Ala
                 885                 890                 895    
 Leu Met Gly Glu Thr Val Gly Gln Val Ser Lys Glu Ser Lys His Ile
             900                 905                 910        
 Trp Lys Leu Gln Trp Ala Thr Thr Ile Leu Asp Ile Glu Arg Ser Phe
         915                 920                 925            
 Pro Val Phe Leu Arg Lys Ala Phe Arg Ser Gly Glu Met Val Thr Val
     930                 935                 940                
 Gly Lys Ser Ser Asp Gly Thr Pro Asp Arg Arg Trp Cys Phe Arg Val
 945                 950                 955                 960
 Asn Glu Val Asn Trp Ser His Trp Asn Gln Asn Leu Gly Ile Ile Asn
                 965                 970                 975    
 Glu Asp Pro Gly Lys Asn Glu Thr Tyr Gln Tyr Tyr Gly Phe Ser His
             980                 985                 990        
 Thr Val Gly Arg Leu Arg Arg Asp Arg Trp Ser Ser Val Val Pro Arg
         995                1000                1005            
 Val Val Glu Leu Asn Lys Asn Ser Asn Pro Asp Glu Val Val Val Pro
    1010                1015                1020                
 Leu Asp Ser Met Gly Asn Pro Arg Cys Asp Gly His Gln Gln Gly Tyr
1025                1030                1035                1040
 Pro Arg Lys Trp Arg Thr Asp Asp Ala Pro Leu
                1045                1050    



      <210> 1440
      <211> 148
      <212> PRT
      <213> Homo sapiens


      <400> 1440
 Met Gln Leu Glu Cys Phe Asn Leu His Ile Tyr Asp Asp Val Gly Tyr
   1               5                  10                  15    
 Gly Arg Tyr Leu Leu Phe Leu Gln Ala Val Ser Leu Phe Leu Leu Asp
              20                  25                  30        
 Ile Leu Pro Leu Glu Gln Ser Asp Lys Val Tyr Glu Val Tyr Lys Ile
          35                  40                  45            
 Tyr Ile Phe Ser Leu Phe Leu Gly Tyr Leu Leu Gln Phe Gly Asn Pro
      50                  55                  60                
 Ala Val Leu Val Phe Pro Leu Leu Ser Leu Leu Ala Ala Leu Met Ile
  65                  70                  75                  80
 Ala Lys Cys Leu Gln Leu Asn Ala Lys Lys Glu Thr Phe Val Ala Lys
                  85                  90                  95    
 Thr Met Lys Val Ile Asn Phe Tyr Leu Val Arg Thr Leu Thr Val Thr
             100                 105                 110        
 Leu Asn Ile Ile Met Lys Met Phe Val Gln His Lys Glu Asn Gly Arg
         115                 120                 125            
 Met Leu Lys Phe Leu Glu Val Lys Phe Gly Leu Asn Met Thr Lys Asn
     130                 135                 140                
 Phe Thr Val Ile
 145            



      <210> 1441
      <211> 251
      <212> PRT
      <213> Homo sapiens


      <400> 1441
 Met Lys Asn Tyr Glu Ser Lys Lys Tyr Ser Asp Pro Ser Gln Pro Gly
   1               5                  10                  15    
 Asn Thr Val Leu His Pro Gly Thr Arg Leu Ile Gln Lys Leu His Thr
              20                  25                  30        
 Ser Thr Cys Trp Leu Gln Glu Val Pro Gly Lys Pro Gln Leu Glu Gln
          35                  40                  45            
 Ala Thr Lys His Pro Gln Val Thr Ser Pro Gln Ala Thr Lys Glu Thr
      50                  55                  60                
 Gly Met Glu Ile Lys Glu Gly Lys Gln Ser Tyr Arg Gln Lys Ile Met
  65                  70                  75                  80
 Asp Glu Leu Lys Tyr Tyr Tyr Asn Gly Phe Tyr Leu Leu Trp Ile Asp
                  85                  90                  95    
 Ala Lys Val Ala Ala Arg Met Val Trp Arg Leu Leu His Gly Gln Val
             100                 105                 110        
 Leu Thr Arg Arg Glu Arg Arg Arg Leu Leu Arg Thr Cys Val Asp Phe
         115                 120                 125            
 Phe Arg Leu Val Pro Phe Met Val Phe Leu Ile Val Pro Phe Met Glu
     130                 135                 140                
 Phe Leu Leu Pro Val Phe Leu Lys Leu Phe Pro Glu Met Leu Pro Ser
 145                 150                 155                 160
 Thr Phe Glu Ser Glu Ser Lys Lys Glu Glu Lys Gln Lys Lys Lys Met
                 165                 170                 175    
 Ala Val Lys Leu Glu Leu Ala Lys Phe Leu Gln Glu Thr Met Thr Glu
             180                 185                 190        
 Met Ala Arg Arg Asn Arg Ala Lys Met Gly Asp Ala Ser Thr Gln Leu
         195                 200                 205            
 Ser Ser Tyr Val Lys Gln Val Ser Ile Phe Tyr Val Met Pro Asn Asn
     210                 215                 220                
 Phe Gly Ala Gly Arg Ser Met Lys Asn Ala Cys His His Gly Phe Pro
 225                 230                 235                 240
 Lys Leu Phe Thr Ile Phe Gly Ile Ala Asn Ile
                 245                 250    



      <210> 1442
      <211> 294
      <212> PRT
      <213> Homo sapiens


      <400> 1442
 Met Arg Pro Arg Ala Pro Ala Cys Ala Ala Ala Ala Leu Gly Leu Cys
   1               5                  10                  15    
 Ser Leu Leu Leu Leu Leu Ala Pro Gly His Ala Cys Pro Ala Gly Cys
              20                  25                  30        
 Ala Cys Thr Asp Pro His Thr Val Asp Cys Arg Asp Arg Gly Leu Pro
          35                  40                  45            
 Ser Val Pro Asp Pro Phe Pro Leu Asp Val Arg Lys Leu Leu Val Ala
      50                  55                  60                
 Gly Asn Arg Ile Gln Arg Ile Pro Glu Asp Phe Phe Ile Phe Tyr Gly
  65                  70                  75                  80
 Asp Leu Val Tyr Leu Asp Phe Arg Asn Asn Ser Leu Arg Ser Leu Glu
                  85                  90                  95    
 Glu Gly Thr Phe Ser Gly Ser Ala Lys Leu Val Phe Leu Asp Leu Ser
             100                 105                 110        
 Tyr Asn Asn Leu Thr Gln Leu Gly Ala Gly Ala Phe Arg Ser Ala Gly
         115                 120                 125            
 Arg Leu Val Lys Leu Ser Leu Ala Asn Asn Asn Leu Val Gly Val His
     130                 135                 140                
 Glu Asp Ala Phe Glu Thr Leu Glu Ser Leu Gln Val Leu Glu Leu Asn
 145                 150                 155                 160
 Asp Asn Asn Leu Arg Ser Leu Ser Val Ala Ala Leu Ala Ala Leu Pro
                 165                 170                 175    
 Ala Leu Arg Ser Leu Arg Leu Asp Gly Asn Pro Trp Leu Cys Asp Cys
             180                 185                 190        
 Asp Phe Ala His Leu Phe Ser Trp Ile Gln Glu Asn Ala Ser Lys Leu
         195                 200                 205            
 Pro Lys Gly Leu Asp Glu Ile Gln Cys Ser Leu Pro Met Glu Ser Arg
     210                 215                 220                
 Arg Ile Ser Leu Arg Glu Leu Ser Glu Ala Ser Phe Ser Glu Cys Arg
 225                 230                 235                 240
 Phe Ser Leu Ser Leu Thr Asp Leu Cys Ile Ile Ile Phe Ser Gly Val
                 245                 250                 255    
 Ala Val Ser Ile Ala Ala Ile Ile Ser Ser Phe Phe Leu Ala Thr Val
             260                 265                 270        
 Val Gln Cys Leu Gln Arg Cys Ala Pro Asn Lys Asp Ala Glu Asp Glu
         275                 280                 285            
 Asp Glu Asp Lys Asp Asp
     290                



      <210> 1443
      <211> 497
      <212> PRT
      <213> Homo sapiens


      <400> 1443
 Met Thr Pro Lys Lys Pro Lys Gly Glu Met Ser Ala Tyr Ala Phe Phe
   1               5                  10                  15    
 Met Gln Thr Cys Arg Glu Glu Cys Lys Lys Lys Asn Pro Glu Val Leu
              20                  25                  30        
 Val Asn Phe Thr Glu Ile Ser Lys Lys Cys Ser Glu Arg Arg Lys Thr
          35                  40                  45            
 Met Cys Gly Lys Glu Lys Ser Lys Pro Asp Glu Met Thr Glu Val Asp
      50                  55                  60                
 Glu Val Leu Tyr Asp Trp Glu Ile Lys Asn Tyr Gly Pro Ala Lys Gly
  65                  70                  75                  80
 Gly Lys Lys Lys Asp Pro Lys Ala Pro Lys Arg Leu Pro Ser Gly Phe
                  85                  90                  95    
 Phe Leu Phe Cys Ser Glu Phe Cys Pro Glu Asp Lys Ser Thr Asn Pro
             100                 105                 110        
 Gly Ile Ser Ile Gly Asp Val Ala Lys Arg Leu Arg Thr Thr Gly Asp
         115                 120                 125            
 Trp Ser Ser Glu Gly Cys Ser Thr Glu Val Arg Pro Glu Gly Thr Val
     130                 135                 140                
 Cys Cys Cys Asp His Leu Thr Phe Phe Ala Leu Leu Leu Arg Pro Thr
 145                 150                 155                 160
 Leu Asp Gln Ser Thr Val His Ile Leu Thr Arg Ile Ser Gln Ala Gly
                 165                 170                 175    
 Cys Gly Val Ser Met Ile Phe Leu Ala Phe Thr Ile Ile Leu Tyr Ala
             180                 185                 190        
 Phe Leu Ser Pro Gly Leu Gly His Gly Pro His Pro Gln Gln Ala Glu
         195                 200                 205            
 Cys Asp Leu Pro Ala Gly Arg Ile Ala Gly Pro Cys Glu Arg Gly Leu
     210                 215                 220                
 Glu Arg Gln Glu Lys Leu Pro Pro Ala Pro Gln Gly Gly Ala Trp His
 225                 230                 235                 240
 Leu Arg Leu Ser Arg Glu Arg Phe Lys Ser Glu Asp Ala Pro Lys Ile
                 245                 250                 255    
 His Val Ala Leu Gly Gly Ser Leu Phe Leu Leu Asn Leu Ala Phe Leu
             260                 265                 270        
 Val Asn Val Gly Ser Gly Ser Lys Gly Ser Asp Ala Ala Cys Trp Ala
         275                 280                 285            
 Arg Gly Ala Val Phe His Tyr Phe Leu Leu Cys Ala Phe Thr Trp Met
     290                 295                 300                
 Gly Leu Glu Ala Phe His Leu Tyr Leu Leu Ala Val Arg Val Phe Asn
 305                 310                 315                 320
 Thr Tyr Phe Gly His Tyr Phe Leu Lys Leu Ser Leu Val Gly Trp Gly
                 325                 330                 335    
 Leu Pro Ala Leu Met Val Ile Gly Thr Gly Ser Ala Asn Ser Tyr Gly
             340                 345                 350        
 Leu Tyr Thr Ile Arg Asp Arg Glu Asn Arg Thr Ser Leu Glu Leu Cys
         355                 360                 365            
 Trp Phe Arg Glu Gly Thr Thr Met Tyr Ala Leu Tyr Ile Thr Val His
     370                 375                 380                
 Gly Tyr Phe Leu Ile Thr Phe Leu Phe Gly Met Val Val Leu Ala Leu
 385                 390                 395                 400
 Val Val Trp Lys Ile Phe Thr Leu Ser Arg Ala Thr Ala Val Lys Glu
                 405                 410                 415    
 Arg Gly Lys Asn Arg Lys Lys Val Leu Thr Leu Leu Gly Leu Ser Ser
             420                 425                 430        
 Leu Val Gly Val Thr Trp Gly Leu Ala Ile Phe Thr Pro Leu Gly Leu
         435                 440                 445            
 Ser Thr Val Tyr Ile Phe Ala Leu Phe Asn Ser Leu Gln Gly Val Phe
     450                 455                 460                
 Ile Cys Cys Trp Phe Thr Ile Leu Tyr Leu Pro Ser Gln Ser Thr Thr
 465                 470                 475                 480
 Val Ser Ser Ser Thr Ala Arg Leu Asp Gln Ala His Ser Ala Ser Gln
                 485                 490                 495    
 Glu
    



      <210> 1444
      <211> 275
      <212> PRT
      <213> Homo sapiens


      <400> 1444
 Met Ala Asp Thr His His Ala Gln Gly Pro Gly Lys Ser Val Leu Gly
   1               5                  10                  15    
 Ile Gly Gln Arg Ile Val Ser Ile Met Val Glu Met Val Glu Thr Arg
              20                  25                  30        
 Leu Arg Leu Ala Val Val Glu Leu Glu Glu Glu Lys Ala Asn Leu Phe
          35                  40                  45            
 Gln Leu Leu Leu Met Leu Gly Leu Thr Met Leu Phe Ala Ala Phe Gly
      50                  55                  60                
 Leu Met Ser Leu Met Val Leu Ile Ile Trp Ala Gly Asp Pro Gln Tyr
  65                  70                  75                  80
 Arg Leu Asn Ala Met Ile Ala Thr Thr Val Val Leu Leu Leu Leu Ala
                  85                  90                  95    
 Leu Ile Gly Gly Ile Trp Thr Leu Arg Lys Ser Gly Lys Ser Thr Leu
             100                 105                 110        
 Leu Arg His Thr Arg His Glu Leu Ala Asn Asp Arg Gln Leu Leu Glu
         115                 120                 125            
 Glu Glu Ser Pro Asp Val Val Gly Glu Val Ile Leu Val Gly Asn Met
     130                 135                 140                
 Pro Ala Arg Val Ile Gly Val Ala Glu Glu Lys Gln Ser Met Phe Gly
 145                 150                 155                 160
 Ser Ser Lys Val Leu Arg Val Trp Leu Pro Tyr Ser Thr Met Ser Gly
                 165                 170                 175    
 Arg Val Met Gly Gln Ser Trp Leu Asn Ser Ile Thr Val Arg Val Lys
             180                 185                 190        
 Glu Gly Phe Asp Ser Ala Glu Ala Glu Gln Gln Leu Thr Arg Leu Leu
         195                 200                 205            
 Ser Leu Arg His Gly Lys Lys Asp Phe Phe Thr Trp Asn Met Asp Gly
     210                 215                 220                
 Val Leu Lys Thr Val Glu Lys Thr Thr Arg Thr Leu Gln Leu Phe Leu
 225                 230                 235                 240
 Thr Leu Val Ala Val Ile Ser Leu Val Val Gly Gly Ile Gly Val Met
                 245                 250                 255    
 Asn Ile Ile Leu Val Ser Val Thr Arg Pro Thr Arg Glu Ile Gly Ile
             260                 265                 270        
 Arg Ile Ala
         275



      <210> 1445
      <211> 290
      <212> PRT
      <213> Homo sapiens


      <400> 1445
 Met Val Ser Glu Met Val Leu Leu Lys Lys Trp Phe Leu Ser Cys Ser
   1               5                  10                  15    
 Glu Ala Gly Asp Gly Gly Lys Asp Cys Cys Gly Gln Trp Glu Gln Gln
              20                  25                  30        
 Glu Lys Ala Pro Glu Val Gly Thr Ser Leu Val Trp Val Glu His Gly
          35                  40                  45            
 Glu Gly Gln Leu Glu Arg Glu Ala Ser Lys Leu Glu Lys Leu Arg Gln
      50                  55                  60                
 Ile Leu Phe Gly Asn Thr Val His Val Phe Ser Tyr Asn Trp Lys Lys
  65                  70                  75                  80
 Ala Tyr Phe Arg Phe His Asp Pro Ser Ser Glu Leu Ala Phe Thr Leu
                  85                  90                  95    
 Glu Val Gly Lys Gly Gly Ala Arg Ser Ile Gln Met Ala Val Gln Gly
             100                 105                 110        
 Ser Ile Ile Lys Tyr Leu Leu Phe Thr Arg Lys Gly Lys Asp Cys Asn
         115                 120                 125            
 Leu Gly Asn Leu Cys Glu Ile Ser Lys Lys Glu Gln Glu Gln Ala Leu
     130                 135                 140                
 Ala Ala Ala Leu Ala Gly Ile Leu Trp Ala Ala Gly Ala Ala Gln Lys
 145                 150                 155                 160
 Ala Thr Ile Cys Leu Val Thr Glu Asp Ile Tyr Val Ala Ser Thr Pro
                 165                 170                 175    
 Asp Tyr Ser Val Asp Asn Phe Thr Glu Arg Val Ser Ala Val Leu Pro
             180                 185                 190        
 Val Leu Ala Asp Glu Arg Pro Val Lys Pro Glu His Val Ile Asp Leu
         195                 200                 205            
 Pro Cys Val Cys Arg Trp Gly Pro Ile His Ala Pro Asp Val Thr Gly
     210                 215                 220                
 Gly Ala Phe Gln Arg Gly Arg Leu Gln Met Asp Leu Asp Val Thr Thr
 225                 230                 235                 240
 Thr Gln Leu Leu Gln Pro Asn Ala Gly Gly Phe Leu Cys Arg Gln Lys
                 245                 250                 255    
 Pro Leu Gly Leu Leu Thr Thr Cys Arg Ser Leu Ser Leu Gly Cys Val
             260                 265                 270        
 Pro Leu Met Leu Gly Pro Gly Pro Val Gln Gly Ser Gln Leu Trp Gln
         275                 280                 285            
 Gln His
     290



      <210> 1446
      <211> 872
      <212> PRT
      <213> Homo sapiens


      <400> 1446
 Met Ala Ala Ala Val Leu Ser Gly Pro Ser Ala Gly Ser Ala Ala Gly
   1               5                  10                  15    
 Val Pro Gly Gly Thr Gly Gly Leu Ser Ala Val Ser Ser Gly Pro Arg
              20                  25                  30        
 Leu Arg Leu Leu Leu Leu Glu Ser Val Ser Gly Leu Leu Gln Pro Arg
          35                  40                  45            
 Thr Gly Ser Ala Val Ala Pro Val His Pro Pro Asn Arg Ser Ala Pro
      50                  55                  60                
 His Leu Pro Gly Leu Met Cys Leu Leu Arg Leu His Gly Ser Val Gly
  65                  70                  75                  80
 Gly Ala Gln Asn Leu Ser Ala Leu Gly Ala Leu Val Ser Leu Ser Asn
                  85                  90                  95    
 Ala Arg Leu Ser Ser Ile Lys Thr Arg Phe Glu Gly Leu Cys Leu Leu
             100                 105                 110        
 Ser Leu Leu Val Gly Glu Ser Pro Thr Glu Leu Phe Gln Gln His Cys
         115                 120                 125            
 Val Ser Trp Leu Arg Ser Ile Gln Gln Val Leu Gln Thr Gln Asp Pro
     130                 135                 140                
 Pro Ala Thr Met Glu Leu Ala Val Ala Val Leu Arg Asp Leu Leu Arg
 145                 150                 155                 160
 Tyr Ala Ala Gln Leu Pro Ala Leu Phe Arg Asp Ile Ser Met Asn His
                 165                 170                 175    
 Leu Pro Gly Leu Leu Thr Ser Leu Leu Gly Leu Arg Pro Glu Cys Glu
             180                 185                 190        
 Gln Ser Ala Leu Glu Gly Met Lys Ala Cys Met Thr Tyr Phe Pro Arg
         195                 200                 205            
 Ala Cys Gly Ser Leu Lys Gly Lys Leu Ala Ser Phe Phe Leu Ser Arg
     210                 215                 220                
 Val Asp Pro Leu Ser Pro Gln Leu Gln Gln Leu Ala Cys Glu Cys Tyr
 225                 230                 235                 240
 Ser Arg Leu Pro Ser Leu Gly Ala Gly Phe Ser Gln Gly Leu Lys His
                 245                 250                 255    
 Thr Glu Ser Trp Glu Gln Glu Leu His Ser Leu Leu Ala Ser Leu His
             260                 265                 270        
 Thr Leu Leu Gly Ala Leu Tyr Glu Gly Ala Glu Thr Ala Pro Val Gln
         275                 280                 285            
 Asn Glu Gly Pro Gly Val Glu Met Leu Leu Ser Ser Glu Asp Gly Asp
     290                 295                 300                
 Ala His Val Leu Leu Gln Leu Arg Gln Arg Phe Ser Gly Leu Ala Arg
 305                 310                 315                 320
 Cys Leu Gly Leu Met Leu Ser Ser Glu Phe Gly Ala Pro Val Ser Val
                 325                 330                 335    
 Pro Val Gln Glu Ile Leu Asp Phe Ile Cys Arg Thr Leu Ser Val Ser
             340                 345                 350        
 Ser Lys Asn Ile Val Ser Gly Ile Cys His Leu Phe Arg Ala Leu Ala
         355                 360                 365            
 Gln Asp Thr Arg Gln Pro Gly Lys Tyr Trp Gly Pro Glu Ser Pro Gln
     370                 375                 380                
 Thr Val Ser Ser Trp Ser Pro Ser Gln Arg Ala Ser Thr Phe Val Gln
 385                 390                 395                 400
 Ile Thr Ser Leu Pro Met Cys Arg Asp Thr Gly Ala Gln Cys Gln Ser
                 405                 410                 415    
 Val Ala Asn Ala Ser Leu Gly Glu Gly Glu Phe Gly Asp Ser Ala Glu
             420                 425                 430        
 Ser Leu Leu Arg Gly Pro Ala Ile Leu Leu Thr Phe His Pro Gly Ser
         435                 440                 445            
 Ile Leu Glu Asp Arg Gly Leu Ile Leu Leu Gly Glu Met Arg Ser Gly
     450                 455                 460                
 Val Gly Phe Leu Thr Tyr Val Tyr Ile Cys Lys Trp Ser Phe Pro Val
 465                 470                 475                 480
 Ser Val Ser Leu Trp Leu Ser Leu Ser Ser Ser Thr Leu Tyr Leu Cys
                 485                 490                 495    
 Pro Phe Phe Leu Gln Ser Leu His Gly Asp Gly Pro Cys Gly Cys Cys
             500                 505                 510        
 Cys Cys Pro Leu Ser Thr Leu Lys Ala Leu Asp Leu Leu Ser Ala Leu
         515                 520                 525            
 Ile Leu Ala Cys Gly Ser Arg Leu Leu Arg Phe Gly Ile Leu Ile Gly
     530                 535                 540                
 Arg Leu Leu Pro Gln Val Leu Asn Ser Trp Ser Ile Gly Arg Asp Ser
 545                 550                 555                 560
 Leu Ser Pro Gly Gln Glu Arg Pro Tyr Ser Thr Val Arg Thr Lys Val
                 565                 570                 575    
 Tyr Ala Ile Leu Glu Leu Trp Val Gln Val Cys Gly Ala Ser Ala Gly
             580                 585                 590        
 Met Leu Gln Gly Gly Ala Ser Gly Glu Ala Leu Leu Thr His Leu Leu
         595                 600                 605            
 Ser Asp Ile Ser Pro Pro Ala Asp Ala Leu Lys Leu Arg Ser Pro Arg
     610                 615                 620                
 Gly Ser Pro Asp Gly Ser Leu Gln Thr Gly Lys Pro Ser Ala Pro Lys
 625                 630                 635                 640
 Lys Leu Lys Leu Asp Val Gly Glu Ala Met Ala Pro Pro Ser His Arg
                 645                 650                 655    
 Lys Gly Asp Ser Asn Ala Asn Ser Asp Val Cys Ala Ala Ala Leu Arg
             660                 665                 670        
 Gly Leu Ser Arg Thr Ile Leu Met Cys Gly Pro Leu Ile Lys Glu Glu
         675                 680                 685            
 Thr His Arg Arg Leu His Asp Leu Val Leu Pro Leu Val Met Gly Val
     690                 695                 700                
 Gln Gln Gly Glu Val Leu Gly Ser Ser Pro Tyr Thr Ser Ser Arg Cys
 705                 710                 715                 720
 Arg Arg Glu Leu Tyr Cys Leu Leu Leu Ala Leu Leu Leu Ala Pro Ser
                 725                 730                 735    
 Pro Arg Cys Pro Pro Pro Leu Ala Cys Ala Leu Gln Ala Phe Ser Leu
             740                 745                 750        
 Gly Gln Arg Glu Asp Ser Leu Glu Val Ser Ser Phe Cys Ser Glu Ala
         755                 760                 765            
 Leu Val Thr Cys Ala Ala Leu Thr His Pro Arg Val Pro Pro Leu Gln
     770                 775                 780                
 Pro Met Gly Pro Thr Cys Pro Thr Pro Ala Pro Val Pro Pro Pro Glu
 785                 790                 795                 800
 Ala Pro Ser Pro Phe Arg Ala Pro Pro Phe His Pro Pro Gly Pro Met
                 805                 810                 815    
 Pro Ser Val Gly Ser Met Pro Ser Ala Gly Pro Met Pro Phe Ser Arg
             820                 825                 830        
 Pro His Ala Leu Ser Arg Pro Cys Ala Leu Gly Thr Pro Trp Thr Ser
         835                 840                 845            
 His His Ser Gln Pro Pro Arg Pro Phe Cys Pro Arg Pro Ser Val Cys
     850                 855                 860                
 Pro Ser Pro Ala Ser Ser Trp Pro
 865                 870        



      <210> 1447
      <211> 75
      <212> PRT
      <213> Homo sapiens


      <400> 1447
 Met Ile Leu Tyr Thr Ile Phe Leu Lys Val Gln Glu Asp Ser Ala Asp
   1               5                  10                  15    
 Tyr Gly Asp Leu Trp Ala Ser Leu Arg Ile Ala Phe Pro Leu Arg Phe
              20                  25                  30        
 Phe Leu Ser Val Ser His Thr Phe Ser Pro Asn Phe Arg His Thr Leu
          35                  40                  45            
 Pro Ala Phe Pro Leu Leu Ile His Ser Ser Pro Ser Leu Asn Leu Ile
      50                  55                  60                
 Val Tyr Pro Val Ala Cys Cys Leu Thr Val His
  65                  70                  75



      <210> 1448
      <211> 1208
      <212> PRT
      <213> Homo sapiens


      <400> 1448
 Met Gly Ala Leu Leu Pro Leu Leu Glu Arg Val Ala Ala Gln Pro Lys
   1               5                  10                  15    
 Glu Ala Glu Ala Gly Pro Ala Glu Thr His Asp Leu Val Gly Pro Glu
              20                  25                  30        
 Leu Thr Ser Gly His Asn Thr Gln Gly Leu Val Leu Pro Leu Gly Lys
          35                  40                  45            
 Ser Ser Glu Glu Arg Met Glu Arg Asn Ala Val Ala Ala Phe Leu Leu
      50                  55                  60                
 Met Leu Arg Asn Phe Leu Gln Gly His Met Val Asn Gln Glu Ser Leu
  65                  70                  75                  80
 Val Gln Cys Gln Gly Pro Ala Ile Ile Gly Ala Leu Leu Arg Lys Val
                  85                  90                  95    
 Pro Ser Trp Ala Met Asp Met Asn Val Leu Met Ser Ala Gln Leu Leu
             100                 105                 110        
 Met Glu Gln Val Ala Ala Glu Gly Ser Gly Pro Leu Leu Tyr Leu Leu
         115                 120                 125            
 Tyr Gln His Leu Leu Phe Asn Phe His Leu Trp Thr Leu Ser Asp Phe
     130                 135                 140                
 Ala Val Arg Leu Gly His Ile Gln Tyr Met Ser Ser Ile Val Arg Glu
 145                 150                 155                 160
 His Arg Gln Lys Leu Arg Lys Lys Tyr Gly Val Gln Phe Ile Leu Asp
                 165                 170                 175    
 Ala Leu Arg Thr His Tyr Ser Pro Gln Arg Glu Arg Pro Leu Ala Ala
             180                 185                 190        
 Asp Asp Leu Arg Thr Val Gln Thr Ser Leu Leu Gly Leu Ala Arg Glu
         195                 200                 205            
 Phe Leu Val Arg Ser Leu Ser Ala Asp Asp Val Gln Val Thr Gln Thr
     210                 215                 220                
 Met Leu Ser Phe Leu Ala Ala Thr Gly Asp Asp Gly Gln Ala Val Gly
 225                 230                 235                 240
 Ala Leu Asp Leu Leu Leu Ala Leu Leu His Gly Ser Leu Val Gln Glu
                 245                 250                 255    
 Ser Leu Ala Val Phe Leu Leu Glu Pro Gly Asn Leu Glu Val Leu Leu
             260                 265                 270        
 Ala Leu Leu Val Arg Pro Gly Ser Leu Pro Leu Leu Pro Asp Arg Val
         275                 280                 285            
 Cys Lys Ile Leu Arg Arg Leu Gln Gln Asn Glu Arg Leu Pro Glu Arg
     290                 295                 300                
 Ser Arg Gln Arg Leu Arg Leu Arg Glu Cys Gly Leu Gln Gly Leu Val
 305                 310                 315                 320
 Ala Cys Leu Pro Glu Gly Thr Val Ser Pro Gln Leu Cys Gln Gly Leu
                 325                 330                 335    
 Tyr Lys Leu Phe Leu Gly Ala Asp Cys Leu Asn Leu Ser Asp Leu Leu
             340                 345                 350        
 Ala Val Val Gln Leu Ser Leu Gln Ala Asp Leu Ser Val Arg Leu Asp
         355                 360                 365            
 Ile Cys Arg Gln Leu Phe His Leu Ile Tyr Gly Gln Pro Asp Val Val
     370                 375                 380                
 Arg Leu Leu Ala Arg Gln Ala Gly Trp Gln Asp Val Leu Thr Arg Leu
 385                 390                 395                 400
 Tyr Val Leu Glu Ala Ala Thr Ala Gly Ser Pro Pro Pro Ser Ser Pro
                 405                 410                 415    
 Glu Ser Pro Thr Ser Pro Lys Pro Ala Pro Pro Lys Pro Pro Thr Glu
             420                 425                 430        
 Ser Pro Ala Glu Pro Ser Asp Val Phe Leu Pro Ser Glu Ala Pro Cys
         435                 440                 445            
 Pro Asp Pro Asp Gly Phe Tyr His Ala Leu Ser Pro Phe Cys Thr Pro
     450                 455                 460                
 Phe Asp Leu Gly Leu Glu Arg Ser Ser Val Gly Ser Gly Asn Thr Ala
 465                 470                 475                 480
 Gly Gly Gly Gly Ser Ser Gly Thr Leu Thr Pro Ala Ser Gln Pro Gly
                 485                 490                 495    
 Thr Pro Ser Pro Leu Asp Gly Pro Arg Pro Phe Pro Ala Ala Pro Gly
             500                 505                 510        
 Arg His Ser Ser Ser Leu Ser Asn Val Leu Glu Asp Gly Ser Leu Pro
         515                 520                 525            
 Glu Pro Thr Ile Ser Gly Asp Asp Thr Ser Asn Thr Ser Asn Pro Gln
     530                 535                 540                
 Gln Thr Ser Glu Glu Glu Leu Cys Asn Leu Leu Thr Asn Val Leu Phe
 545                 550                 555                 560
 Ser Val Thr Trp Arg Gly Val Glu Gly Ser Asp Glu Ala Ala Trp Arg
                 565                 570                 575    
 Glu Arg Gly Gln Val Phe Ser Val Leu Thr Gln Leu Gly Ala Ser Ala
             580                 585                 590        
 Thr Leu Val Arg Pro Pro Asp Cys Ile Lys Arg Ser Leu Leu Glu Met
         595                 600                 605            
 Met Leu Glu Ser Ala Leu Thr Asp Ile Lys Glu Ala Pro Val Gly Val
     610                 615                 620                
 Leu Ala Ser Leu Thr Gln Gln Ala Leu Trp Leu Leu Arg Leu Leu Gln
 625                 630                 635                 640
 Asp Phe Leu Cys Ala Glu Gly His Gly Asn Gln Glu Leu Trp Ser Glu
                 645                 650                 655    
 Lys Leu Phe Glu Gly Val Cys Ser Leu Leu Asp Arg Leu Gly Ala Trp
             660                 665                 670        
 Pro His Leu Ala Asn Gly Thr Ala Asp Leu Arg Glu Met Ala Gln Ile
         675                 680                 685            
 Gly Leu Arg Leu Val Leu Gly Tyr Ile Leu Leu Glu Asp Pro Gln Leu
     690                 695                 700                
 His Ala Gln Ala Tyr Val Arg Leu His Met Leu Leu Gln Thr Ala Val
 705                 710                 715                 720
 Pro Ala Arg Arg Glu Glu Ala Cys Tyr Val Leu Ser Lys Leu Glu Ala
                 725                 730                 735    
 Ala Leu Gly Arg Val Leu Asn Thr Ser Ser Leu Glu Ser Ala Thr Asp
             740                 745                 750        
 Glu Ala Gly Ser Pro Leu Ala Ala Ala Ala Ala Ala Ala Ala Ala Glu
         755                 760                 765            
 Arg Cys Ser Trp Leu Val Pro Leu Val Arg Thr Leu Leu Asp Arg Ala
     770                 775                 780                
 Tyr Glu Pro Leu Gly Leu Gln Trp Gly Leu Pro Ser Leu Pro Pro Thr
 785                 790                 795                 800
 Asn Gly Ser Pro Thr Phe Phe Glu Asp Phe Gln Ala Phe Cys Ala Thr
                 805                 810                 815    
 Pro Glu Trp Arg His Phe Ile Asp Lys Gln Val Gln Pro Thr Met Ser
             820                 825                 830        
 Gln Phe Glu Met Asp Thr Tyr Ala Lys Ser His Asp Leu Met Ser Gly
         835                 840                 845            
 Phe Trp Asn Ala Cys Tyr Asp Met Leu Met Ser Ser Gly Gln Arg Arg
     850                 855                 860                
 Gln Trp Glu Arg Ala Gln Ser Arg Arg Ala Phe Gln Glu Leu Val Leu
 865                 870                 875                 880
 Glu Pro Ala Gln Arg Arg Ala Arg Leu Glu Gly Leu Arg Tyr Thr Ala
                 885                 890                 895    
 Val Leu Lys Gln Gln Ala Thr Gln His Ser Met Ala Leu Leu His Trp
             900                 905                 910        
 Gly Ala Leu Trp Arg Gln Leu Ala Ser Pro Cys Gly Ala Trp Ala Leu
         915                 920                 925            
 Arg Asp Thr Pro Ile Pro Arg Trp Lys Leu Ser Ser Ala Glu Thr Tyr
     930                 935                 940                
 Ser Arg Met Arg Leu Lys Leu Val Pro Asn His His Phe Asp Pro His
 945                 950                 955                 960
 Leu Glu Ala Ser Ala Leu Arg Asp Asn Leu Gly Glu Val Pro Leu Thr
                 965                 970                 975    
 Pro Thr Glu Glu Ala Ser Leu Pro Leu Ala Val Thr Lys Glu Ala Lys
             980                 985                 990        
 Val Ser Thr Pro Pro Glu Leu Leu Gln Glu Asp Gln Leu Gly Glu Asp
         995                1000                1005            
 Glu Leu Ala Glu Leu Glu Thr Pro Met Glu Ala Ala Glu Leu Asp Glu
    1010                1015                1020                
 Gln Arg Glu Lys Leu Val Leu Ser Ala Glu Cys Gln Leu Val Thr Val
1025                1030                1035                1040
 Val Ala Val Val Pro Gly Leu Leu Glu Val Thr Thr Gln Asn Val Tyr
                1045                1050                1055    
 Phe Tyr Asp Gly Ser Thr Glu Arg Val Glu Thr Glu Glu Gly Ile Gly
            1060                1065                1070        
 Tyr Asp Phe Arg Arg Pro Leu Ala Gln Leu Arg Glu Val His Leu Arg
        1075                1080                1085            
 Arg Phe Asn Leu Arg Arg Ser Ala Leu Glu Leu Phe Phe Ile Asp Gln
    1090                1095                1100                
 Ala Asn Tyr Phe Leu Asn Phe Pro Cys Lys Val Gly Thr Thr Pro Val
1105                1110                1115                1120
 Ser Ser Pro Ser Gln Thr Pro Arg Pro Gln Pro Gly Pro Ile Pro Pro
                1125                1130                1135    
 His Thr Gln Val Arg Asn Gln Val Tyr Ser Trp Leu Leu Arg Leu Arg
            1140                1145                1150        
 Pro Pro Ser Gln Gly Tyr Leu Ser Ser Arg Ser Pro Gln Glu Met Leu
        1155                1160                1165            
 Arg Ala Ser Gly Leu Thr Gln Lys Trp Val Gln Arg Glu Ile Ser Asn
    1170                1175                1180                
 Phe Glu Tyr Leu Met Gln Leu Asn Thr Ile Ala Gly Arg Thr Tyr Asn
1185                1190                1195                1200
 Asp Leu Ser Gln Tyr Pro Val Val
                1205            



      <210> 1449
      <211> 386
      <212> PRT
      <213> Homo sapiens


      <400> 1449
 Met Ala Ala Leu Tyr Leu Leu Met Glu Ser Trp Ile Ser Arg Gly Ala
   1               5                  10                  15    
 Gln Ala Met Val Phe Lys Pro Asp His Ser Pro Ala Ala Trp Ala Ser
              20                  25                  30        
 Ala Pro Gln Val Gly Gln Leu Asp Ser Arg Cys Leu Pro Ser Gly Ile
          35                  40                  45            
 Leu His Pro Leu Ser Pro His Lys Ile Trp Leu Tyr Gly Gly Leu Trp
      50                  55                  60                
 Phe Leu His Leu His Met Lys Glu Arg Glu Ala Asp Gly Pro Pro Ser
  65                  70                  75                  80
 Ser Tyr Thr Arg Gly Ser Glu Asp Gly Asp Pro Ser Asn Ile Gln Lys
                  85                  90                  95    
 Arg Ser Trp Glu Ile Ser Thr Ala Pro Gly Trp Glu Pro Pro Asp Asp
             100                 105                 110        
 Pro Asp Thr Gly Ser Glu Cys Ser His Pro Glu Val Ser Pro Ser Pro
         115                 120                 125            
 Arg Phe Val Ala Ala Lys Thr Gln Thr Asn Gln Ser Gly Lys Lys Ala
     130                 135                 140                
 Pro Ala Ser Val Val Arg Cys Ala Thr Leu Leu His Arg Thr Pro Pro
 145                 150                 155                 160
 Ala Thr Gln Thr Gln Thr Phe Arg Thr Pro Asn Ser Gly Ser Pro Ala
                 165                 170                 175    
 Ser Lys Ala Thr Ala Ala Glu Ser Ala Phe Ser Arg Arg Val Glu Gly
             180                 185                 190        
 Lys Ala Gln Asn His Phe Glu Glu Thr Asn Ser Ser Ser Gln Asn Ser
         195                 200                 205            
 Ser Ala Arg Ala Glu Phe Leu Cys Val Pro Pro Leu Leu Phe Thr Leu
     210                 215                 220                
 Phe Leu Ser Ala Asp Cys Ile Pro Ser Ser Gly Ala Gly Leu Pro Gly
 225                 230                 235                 240
 Val Pro Gly Lys Arg Gly Lys Met Gly Met Pro Val Lys Ile Phe Arg
                 245                 250                 255    
 Val Tyr Tyr Ala Asp Ser Ser Gly Glu Pro His Leu Pro Arg Pro Arg
             260                 265                 270        
 Cys Pro Gly His Leu Leu Pro Gly Ile Phe Cys Phe Ser Pro Cys Phe
         275                 280                 285            
 Glu Cys Gly Gly Arg Met Trp Gly Cys Leu Ala Thr Gly Pro Ala Ala
     290                 295                 300                
 Gly Thr Arg Arg Asp Trp Gly Leu Ala Gly Ala Gly Ala Ser Met Gly
 305                 310                 315                 320
 Ser Gly Pro Leu Trp Gly Ser Ser Cys Leu Pro Val Gly Ile Ser Gly
                 325                 330                 335    
 Ser Pro Val Gln Phe Cys Val Trp Gly Leu Leu Ser Lys Gly Thr Leu
             340                 345                 350        
 Ser Leu His Ile Val Leu Val Ser Ser Gly Ser Val Gln Phe Ala His
         355                 360                 365            
 Ala His Ala Lys Pro Glu Asp Asn Gly Val Tyr Gly Gln Cys Pro Gln
     370                 375                 380                
 Gln Ala
 385    



      <210> 1450
      <211> 193
      <212> PRT
      <213> Homo sapiens


      <400> 1450
 Met Glu Ser Ile Arg Thr Thr Arg Gln Cys Ser Leu Ser Val His Ala
   1               5                  10                  15    
 Gly Ile Arg Gly Glu Ala Met Arg Phe His Phe Met Asp Glu Gln Asn
              20                  25                  30        
 Pro Lys Gly Arg Asp Lys Ala Ile Val Phe Pro Ala His Thr Thr Ile
          35                  40                  45            
 Ala Phe Ser Val Phe Glu Leu Phe Ile Tyr Leu Asp Gly Ala Phe Asp
      50                  55                  60                
 Leu Cys Val Thr Ser Val Ser Lys Gly Gly Phe Glu Arg Glu Glu Thr
  65                  70                  75                  80
 Ala Thr Phe Ala Leu Leu Tyr Arg Leu Arg Asn Ile Leu Phe Glu Arg
                  85                  90                  95    
 Asn Arg Arg Val Met Asp Val Ile Ser Arg Ser Gln Leu Tyr Leu Asp
             100                 105                 110        
 Asp Leu Phe Ser Asp Tyr Tyr Asp Lys Pro Leu Ser Met Thr Asp Ile
         115                 120                 125            
 Ser Leu Lys Glu Gly Thr His Ile Arg Val Asn Leu Leu Asn His Asn
     130                 135                 140                
 Ile Pro Lys Gly Pro Cys Ile Leu Cys Gly Met Gly Asn Phe Lys Arg
 145                 150                 155                 160
 Glu Thr Val Tyr Gly Cys Phe Gln Cys Ser Val Asp Gly Gln Lys Tyr
                 165                 170                 175    
 Val Arg Leu His Ala Val Pro Cys Phe Asp Ile Trp His Lys Arg Met
             180                 185                 190        
 Lys
    



      <210> 1451
      <211> 103
      <212> PRT
      <213> Homo sapiens


      <400> 1451
 Met Arg Ala Lys Val Pro Pro Ser Pro Pro Glu Val Gly Ala Ser Leu
   1               5                  10                  15    
 Gln Phe Gln Val Pro Val Gly Leu Gly Ile Val Arg Pro Leu Ala Pro
              20                  25                  30        
 Arg Asp Ser Ser Phe Glu Pro Gln Leu Trp Leu Trp Pro Leu Pro Gly
          35                  40                  45            
 Leu Leu Asp Ser Ser Val Leu Pro Ala Ser Arg Leu Leu Val Gly His
      50                  55                  60                
 Arg His Met Val Pro Pro Ala Gly Leu Ser His Leu Gln Val Thr Ala
  65                  70                  75                  80
 Met Val Gln Pro Val Ala Leu Leu Ser Thr Leu Leu Ala Ile Arg Asp
                  85                  90                  95    
 Asp Pro Gln Phe Arg Leu Ala
             100            



      <210> 1452
      <211> 218
      <212> PRT
      <213> Homo sapiens


      <400> 1452
 Met Ser Gly Val Asn Lys Glu Lys Gln His Val Gly Ile Leu Gly Asp
   1               5                  10                  15    
 Lys Ile Gln Val Glu Ile Ser Phe Trp Arg Trp Phe Leu Ala Asn Leu
              20                  25                  30        
 Ala Ser Gly Gly Ala Ala Gly Ala Thr Ser Leu Cys Val Val Tyr Pro
          35                  40                  45            
 Leu Asp Phe Ala Arg Thr Arg Leu Gly Val Asp Ile Gly Lys Gly Pro
      50                  55                  60                
 Glu Glu Arg Gln Phe Lys Gly Leu Gly Asp Cys Ile Met Lys Ile Ala
  65                  70                  75                  80
 Lys Ser Asp Gly Ile Ala Gly Leu Tyr Gln Gly Phe Gly Val Ser Val
                  85                  90                  95    
 Gln Gly Ile Ile Val Tyr Arg Ala Ser Tyr Phe Gly Ala Tyr Asp Thr
             100                 105                 110        
 Val Lys Gly Leu Leu Pro Lys Pro Lys Lys Thr Pro Phe Leu Val Ser
         115                 120                 125            
 Phe Phe Ile Ala Gln Val Val Thr Thr Cys Ser Gly Ile Leu Ser Tyr
     130                 135                 140                
 Pro Phe Asp Thr Val Arg Arg Arg Met Met Met Gln Ser Gly Glu Ala
 145                 150                 155                 160
 Lys Arg Gln Tyr Lys Gly Thr Leu Asp Cys Phe Val Lys Ile Tyr Gln
                 165                 170                 175    
 His Glu Gly Ile Ser Ser Phe Phe Arg Gly Ala Phe Ser Asn Val Leu
             180                 185                 190        
 Arg Gly Thr Gly Gly Ala Leu Val Leu Val Leu Tyr Asp Lys Ile Lys
         195                 200                 205            
 Glu Phe Phe His Ile Asp Ile Gly Gly Arg
     210                 215            



      <210> 1453
      <211> 176
      <212> PRT
      <213> Homo sapiens


      <400> 1453
 Met Gly Gln Pro Ala Pro Val Gly Ala Met Ala Ser Ala Glu Pro Leu
   1               5                  10                  15    
 Thr Ala Leu Ser Arg Trp Tyr Leu Tyr Ala Ile His Gly Tyr Phe Cys
              20                  25                  30        
 Glu Val Met Phe Thr Ala Ala Trp Glu Phe Val Val Asn Leu Asn Trp
          35                  40                  45            
 Lys Phe Pro Gly Val Thr Ser Val Trp Ala Leu Phe Ile Tyr Gly Thr
      50                  55                  60                
 Ser Ile Leu Ile Val Glu Arg Met Tyr Leu Arg Leu Arg Gly Arg Cys
  65                  70                  75                  80
 Pro Leu Leu Leu Arg Cys Leu Ile Tyr Thr Leu Trp Thr Tyr Leu Trp
                  85                  90                  95    
 Glu Phe Thr Thr Gly Phe Ile Leu Arg Gln Phe Asn Ala Cys Pro Trp
             100                 105                 110        
 Asp Tyr Ser Gln Phe Asp Phe Asp Phe Met Gly Leu Ile Thr Leu Glu
         115                 120                 125            
 Tyr Ala Val Pro Trp Phe Cys Gly Ala Leu Ile Met Glu Gln Phe Ile
     130                 135                 140                
 Ile Arg Asn Thr Leu Arg Leu Arg Phe Asp Lys Asp Ala Glu Pro Gly
 145                 150                 155                 160
 Glu Pro Ser Gly Ala Leu Ala Leu Ala Asn Gly His Val Lys Thr Asp
                 165                 170                 175    





      <210> 1454
      <211> 427
      <212> PRT
      <213> Homo sapiens


      <400> 1454
 Met Gly Ala Ser Asp Pro Glu Val Ala Pro Trp Ala Arg Gly Gly Ala
   1               5                  10                  15    
 Ala Gly Met Ala Gly Ala Gly Ala Gly Ala Gly Ala Arg Gly Gly Ala
              20                  25                  30        
 Ala Ala Gly Val Glu Ala Arg Ala Arg Asp Pro Pro Pro Ala His Arg
          35                  40                  45            
 Ala His Pro Arg His Pro Arg Pro Ala Ala Gln Pro Ser Ala Arg Arg
      50                  55                  60                
 Met Asp Gly Gly Ser Gly Gly Leu Gly Ser Gly Asp Asn Ala Pro Thr
  65                  70                  75                  80
 Thr Glu Ala Leu Phe Val Ala Leu Gly Ala Gly Val Thr Ala Leu Ser
                  85                  90                  95    
 His Pro Leu Leu Tyr Val Lys Leu Leu Ile Gln Val Gly His Glu Pro
             100                 105                 110        
 Met Pro Pro Thr Leu Gly Thr Asn Val Leu Gly Arg Lys Val Leu Tyr
         115                 120                 125            
 Leu Pro Ser Phe Phe Thr Tyr Ala Lys Tyr Ile Val Gln Val Asp Gly
     130                 135                 140                
 Lys Ile Gly Leu Phe Arg Gly Leu Ser Pro Arg Leu Met Ser Asn Ala
 145                 150                 155                 160
 Leu Ser Thr Val Thr Arg Gly Ser Met Lys Lys Val Phe Pro Pro Asp
                 165                 170                 175    
 Glu Ile Glu Gln Val Ser Asn Lys Asp Asp Met Lys Thr Ser Leu Lys
             180                 185                 190        
 Lys Val Val Lys Glu Thr Ser Tyr Glu Met Met Met Gln Cys Val Ser
         195                 200                 205            
 Arg Met Leu Ala His Pro Leu His Val Ile Ser Met Arg Cys Met Val
     210                 215                 220                
 Gln Phe Val Gly Arg Glu Ala Lys Tyr Ser Gly Val Leu Ser Ser Ile
 225                 230                 235                 240
 Gly Lys Ile Phe Lys Glu Glu Gly Leu Leu Gly Phe Phe Val Gly Leu
                 245                 250                 255    
 Ile Pro His Leu Leu Gly Asp Val Val Phe Leu Trp Gly Cys Asn Leu
             260                 265                 270        
 Leu Ala His Phe Ile Asn Ala Tyr Leu Val Asp Asp Ser Phe Ser Gln
         275                 280                 285            
 Ala Leu Ala Ile Arg Ser Tyr Thr Lys Phe Val Met Gly Ile Ala Val
     290                 295                 300                
 Ser Met Leu Thr Tyr Pro Phe Leu Leu Val Gly Asp Leu Met Ala Val
 305                 310                 315                 320
 Asn Asn Cys Gly Leu Gln Ala Gly Leu Pro Pro Tyr Ser Pro Val Phe
                 325                 330                 335    
 Lys Ser Trp Ile His Cys Trp Lys Tyr Leu Ser Val Arg Ala Ser Ser
             340                 345                 350        
 Ser Glu Ala Pro Ala Cys Phe Ser Ala Gly Cys His Gln Asp His Ala
         355                 360                 365            
 Leu Pro Trp Ser Asn Leu Asn His Leu Lys Asn Thr Val Ser Thr Trp
     370                 375                 380                
 Pro Pro Trp Val Arg Pro Asp His Leu Gly Thr Pro Ala Arg Arg Leu
 385                 390                 395                 400
 Gln Pro Asn Asn Asn Gln Met Cys Ser Ser Pro Ala Gly Leu Gln Phe
                 405                 410                 415    
 His Ile Cys His Val Ser Val Gln Met Trp Gly
             420                 425        



      <210> 1455
      <211> 317
      <212> PRT
      <213> Homo sapiens


      <400> 1455
 Met Lys Asp Gln Arg Leu Val Phe His Ser Lys Val Arg Ser Ser Gly
   1               5                  10                  15    
 Tyr Ala Ser Ala Pro His Val Thr Met Phe Ser Pro Lys Thr Asn Ile
              20                  25                  30        
 Lys Ser Glu Gly Lys Gly Ser Ser Arg Ser Arg Ser Ser Cys Ala Arg
          35                  40                  45            
 Glu Ala Tyr Pro Val Glu Cys Ala Val Pro Thr Lys Pro Gly Pro Gln
      50                  55                  60                
 Val Ala Ala Ala Pro Thr Cys Thr Arg Val Cys Cys Ile Gln Tyr Ser
  65                  70                  75                  80
 Gly Asp Gly Gln Trp Leu Ala Cys Gly Leu Ala Asn His Leu Leu Leu
                  85                  90                  95    
 Val Phe Asp Ala Ser Leu Thr Gly Thr Pro Ala Val Phe Ser Gly His
             100                 105                 110        
 Asp Gly Ala Val Asn Ala Val Cys Trp Ser Gln Asp Arg Arg Trp Leu
         115                 120                 125            
 Leu Ser Ala Ala Arg Asp Gly Thr Leu Arg Met Trp Ser Ala Arg Gly
     130                 135                 140                
 Ala Glu Leu Ala Leu Leu Leu Ile Asp Met Thr Ser Leu Ser Ala Val
 145                 150                 155                 160
 Asn Asp Phe Tyr Ser His Ile Val Leu Ala Ala Gly Arg Asn Arg Thr
                 165                 170                 175    
 Val Glu Val Phe Asp Leu Asn Ala Gly Cys Ser Ala Ala Val Ile Ala
             180                 185                 190        
 Glu Ala His Ser Arg Pro Val His Gln Ile Cys Gln Asn Lys Val Ser
         195                 200                 205            
 Ser Phe Thr Ser Glu Gly His Pro Thr Tyr Asn Leu Ser Met Arg Thr
     210                 215                 220                
 Ala Ile Val Trp Asp Leu Arg Thr Leu Arg Cys Glu Arg His Phe Glu
 225                 230                 235                 240
 Gly His Pro Thr Arg Gly Tyr Pro Cys Gly Ile Ala Phe Ser Pro Cys
                 245                 250                 255    
 Gly Arg Phe Ala Ala Cys Gly Ala Glu Asp Arg His Ala Tyr Val Tyr
             260                 265                 270        
 Glu Met Gly Ser Ser Thr Phe Ser His Arg Leu Ala Gly His Thr Asp
         275                 280                 285            
 Thr Val Thr Gly Val Ala Phe Asn Pro Ser Ala Pro Gln Leu Ala Thr
     290                 295                 300                
 Ala Thr Leu Asp Gly Lys Leu Gln Leu Phe Leu Ala Glu
 305                 310                 315        



      <210> 1456
      <211> 1440
      <212> PRT
      <213> Homo sapiens


      <400> 1456
 Met Met Val Glu Ala Val Lys Val Leu Thr Ser Ser Ser Asp Pro Gly
   1               5                  10                  15    
 His Ile Leu Lys Ile Asn Pro Gln Asp Ile Gln Val Cys Pro Ser Leu
              20                  25                  30        
 Asp Ile Arg Ser Glu Val Ala Glu Leu Arg Gln Leu Glu Asn Cys Ser
          35                  40                  45            
 Val Val Glu Gly His Leu Gln Ile Leu Leu Met Phe Thr Ala Thr Gly
      50                  55                  60                
 Glu Asp Phe Arg Gly Leu Ser Phe Pro Arg Leu Thr Gln Val Thr Asp
  65                  70                  75                  80
 Tyr Leu Leu Leu Phe Arg Val Tyr Gly Leu Glu Ser Leu Arg Asp Leu
                  85                  90                  95    
 Phe Pro Asn Leu Ala Val Ile Arg Gly Thr Arg Leu Phe Leu Gly Tyr
             100                 105                 110        
 Ala Leu Val Ile Phe Glu Met Pro His Leu Arg Asp Val Ala Leu Pro
         115                 120                 125            
 Ala Leu Gly Ala Val Leu Arg Gly Ala Val Arg Val Glu Lys Asn Gln
     130                 135                 140                
 Glu Leu Cys His Leu Ser Thr Ile Asp Trp Gly Leu Leu Gln Pro Ala
 145                 150                 155                 160
 Pro Gly Ala Asn His Ile Val Gly Asn Lys Leu Gly Glu Glu Cys Ala
                 165                 170                 175    
 Asp Val Cys Pro Gly Val Leu Gly Ala Ala Gly Glu Pro Cys Ala Lys
             180                 185                 190        
 Thr Thr Phe Ser Gly His Thr Asp Tyr Arg Cys Trp Thr Ser Ser His
         195                 200                 205            
 Cys Gln Arg Val Cys Pro Cys Pro His Gly Met Ala Cys Thr Ala Arg
     210                 215                 220                
 Gly Glu Cys Cys His Thr Glu Cys Leu Gly Gly Cys Ser Gln Pro Glu
 225                 230                 235                 240
 Asp Pro Arg Ala Cys Val Ala Cys Arg His Leu Tyr Phe Gln Gly Ala
                 245                 250                 255    
 Cys Leu Trp Ala Cys Pro Pro Gly Thr Tyr Gln Tyr Glu Ser Trp Arg
             260                 265                 270        
 Cys Val Thr Ala Glu Arg Cys Ala Ser Leu His Ser Val Pro Gly Arg
         275                 280                 285            
 Ala Ser Thr Phe Gly Ile His Gln Gly Ser Cys Leu Ala Gln Cys Pro
     290                 295                 300                
 Ser Gly Phe Thr Arg Asn Ser Ser Ser Ile Phe Cys His Lys Cys Glu
 305                 310                 315                 320
 Gly Leu Cys Pro Lys Glu Cys Lys Val Gly Thr Lys Thr Ile Asp Ser
                 325                 330                 335    
 Ile Gln Ala Ala Gln Asp Leu Val Gly Cys Thr His Val Glu Gly Ser
             340                 345                 350        
 Leu Ile Leu Asn Leu Arg Gln Gly Tyr Asn Leu Glu Pro Gln Leu Gln
         355                 360                 365            
 His Ser Leu Gly Leu Val Glu Thr Ile Thr Gly Phe Leu Lys Ile Lys
     370                 375                 380                
 His Ser Phe Ala Leu Val Ser Leu Gly Phe Phe Lys Asn Leu Lys Leu
 385                 390                 395                 400
 Ile Arg Gly Asp Ala Met Val Asp Gly Asn Tyr Thr Leu Tyr Val Leu
                 405                 410                 415    
 Asp Asn Gln Asn Leu Gln Gln Leu Gly Ser Trp Val Ala Ala Gly Leu
             420                 425                 430        
 Thr Ile Pro Val Gly Lys Ile Tyr Phe Ala Phe Asn Pro Arg Leu Cys
         435                 440                 445            
 Leu Glu His Ile Tyr Arg Leu Glu Glu Val Thr Gly Thr Arg Gly Arg
     450                 455                 460                
 Gln Asn Lys Ala Glu Ile Asn Pro Arg Thr Asn Gly Asp Arg Ala Ala
 465                 470                 475                 480
 Cys Gln Thr Arg Thr Leu Arg Phe Val Ser Asn Val Thr Glu Ala Asp
                 485                 490                 495    
 Arg Ile Leu Leu Arg Trp Glu Arg Tyr Glu Pro Leu Glu Ala Arg Asp
             500                 505                 510        
 Leu Leu Ser Phe Ile Val Tyr Tyr Lys Glu Ser Pro Phe Gln Asn Ala
         515                 520                 525            
 Thr Glu His Val Gly Pro Asp Ala Cys Gly Thr Gln Ser Trp Asn Leu
     530                 535                 540                
 Leu Asp Val Glu Leu Pro Leu Ser Arg Thr Gln Glu Pro Gly Val Thr
 545                 550                 555                 560
 Leu Ala Ser Leu Lys Pro Trp Thr Gln Tyr Ala Val Phe Val Arg Ala
                 565                 570                 575    
 Ile Thr Leu Thr Thr Glu Glu Asp Ser Pro His Gln Gly Ala Gln Ser
             580                 585                 590        
 Pro Ile Val Tyr Leu Arg Thr Leu Pro Ala Ala Pro Thr Val Pro Gln
         595                 600                 605            
 Asp Val Ile Ser Thr Ser Asn Ser Ser Ser His Leu Leu Val Arg Trp
     610                 615                 620                
 Lys Pro Pro Thr Gln Arg Asn Gly Asn Leu Thr Tyr Tyr Leu Val Leu
 625                 630                 635                 640
 Trp Gln Arg Leu Ala Glu Asp Gly Asp Leu Tyr Leu Asn Asp Tyr Cys
                 645                 650                 655    
 His Arg Gly Leu Arg Leu Pro Thr Ser Asn Asn Asp Pro Arg Phe Asp
             660                 665                 670        
 Gly Glu Asp Gly Asp Pro Glu Ala Glu Met Glu Ser Asp Cys Cys Pro
         675                 680                 685            
 Cys Gln His Pro Pro Pro Gly Gln Val Leu Pro Pro Leu Glu Ala Gln
     690                 695                 700                
 Glu Ala Ser Phe Gln Lys Lys Phe Glu Asn Phe Leu His Asn Ala Ile
 705                 710                 715                 720
 Thr Ile Pro Ile Ser Pro Trp Lys Val Thr Ser Ile Asn Lys Ser Pro
                 725                 730                 735    
 Gln Arg Asp Ser Gly Arg His Arg Arg Ala Ala Gly Pro Leu Arg Leu
             740                 745                 750        
 Gly Gly Asn Ser Ser Asp Phe Glu Ile Gln Glu Asp Lys Val Pro Arg
         755                 760                 765            
 Glu Arg Ala Val Leu Ser Gly Leu Arg His Phe Thr Glu Tyr Arg Ile
     770                 775                 780                
 Asp Ile His Ala Cys Asn His Ala Ala His Thr Val Gly Cys Ser Ala
 785                 790                 795                 800
 Ala Thr Phe Val Phe Ala Arg Thr Met Pro His Arg Glu Ala Asp Gly
                 805                 810                 815    
 Ile Pro Gly Lys Val Ala Trp Glu Ala Ser Ser Lys Asn Ser Val Leu
             820                 825                 830        
 Leu Arg Trp Leu Glu Pro Pro Asp Pro Asn Gly Leu Ile Leu Lys Tyr
         835                 840                 845            
 Glu Ile Lys Tyr Arg Arg Leu Gly Glu Pro Ala Val Leu Arg Tyr Ser
     850                 855                 860                
 Gln Glu Ala Thr Val Leu Cys Val Ser Arg Leu Arg Tyr Ala Lys Phe
 865                 870                 875                 880
 Gly Gly Val His Leu Ala Leu Leu Pro Pro Gly Asn Tyr Ser Ala Arg
                 885                 890                 895    
 Val Arg Ala Thr Ser Leu Ala Gly Asn Gly Ser Trp Thr Asp Ser Val
             900                 905                 910        
 Ala Phe Tyr Ile Leu Gly Pro Glu Glu Glu Asp Ala Gly Gly Leu His
         915                 920                 925            
 Val Leu Leu Thr Ala Thr Pro Val Gly Leu Thr Leu Leu Ile Val Leu
     930                 935                 940                
 Ala Ala Leu Gly Phe Phe Tyr Gly Lys Lys Arg Asn Arg Thr Leu Tyr
 945                 950                 955                 960
 Ala Ser Val Asn Pro Glu Tyr Phe Ser Ala Ser Asp Met Tyr Val Pro
                 965                 970                 975    
 Asp Glu Trp Glu Val Pro Arg Glu Gln Ile Ser Ile Ile Arg Glu Leu
             980                 985                 990        
 Gly Gln Gly Ser Phe Gly Met Val Tyr Glu Gly Leu Ala Arg Gly Leu
         995                1000                1005            
 Glu Ala Gly Glu Glu Ser Thr Pro Val Ala Leu Lys Thr Val Asn Glu
    1010                1015                1020                
 Leu Ala Ser Pro Arg Glu Cys Ile Glu Phe Leu Lys Glu Ala Ser Val
1025                1030                1035                1040
 Met Lys Ala Phe Lys Cys His His Val Val Arg Leu Leu Gly Val Val
                1045                1050                1055    
 Ser Gln Gly Gln Pro Thr Leu Val Ile Met Glu Leu Met Thr Arg Gly
            1060                1065                1070        
 Asp Leu Lys Ser His Leu Arg Ser Leu Arg Pro Glu Ala Glu Asn Asn
        1075                1080                1085            
 Pro Gly Leu Pro Gln Pro Ala Leu Gly Glu Met Ile Gln Met Ala Gly
    1090                1095                1100                
 Glu Ile Ala Asp Gly Met Ala Tyr Leu Ala Ala Asn Lys Phe Val His
1105                1110                1115                1120
 Arg Asp Leu Ala Ala Arg Asn Cys Met Val Ser Gln Asp Phe Thr Val
                1125                1130                1135    
 Lys Ile Gly Gly Thr Glu Asp Phe Gly Met Thr Arg Asp Val Tyr Glu
            1140                1145                1150        
 Thr Asp Tyr Tyr Arg Lys Gly Gly Lys Gly Leu Leu Pro Val Arg Trp
        1155                1160                1165            
 Met Ala Pro Glu Ser Leu Lys Asp Gly Ile Phe Thr Thr His Ser Asp
    1170                1175                1180                
 Val Trp Ser Phe Gly Val Val Leu Trp Glu Ile Val Thr Leu Ala Glu
1185                1190                1195                1200
 Gln Pro Tyr Gln Gly Leu Ser Asn Glu Gln Val Leu Lys Phe Val Met
                1205                1210                1215    
 Asp Gly Gly Val Leu Glu Glu Leu Glu Gly Cys Pro Leu Gln Leu Gln
            1220                1225                1230        
 Glu Leu Met Ser Arg Cys Trp Gln Pro Asn Pro Arg Leu Arg Pro Ser
        1235                1240                1245            
 Phe Thr His Ile Leu Asp Ser Ile Gln Glu Glu Leu Arg Pro Ser Phe
    1250                1255                1260                
 Arg Leu Leu Ser Phe Tyr Tyr Ser Pro Glu Cys Arg Gly Ala Arg Gly
1265                1270                1275                1280
 Ser Leu Pro Thr Thr Asp Ala Glu Pro Asp Ser Ser Pro Thr Pro Arg
                1285                1290                1295    
 Asp Cys Ser Pro Gln Asn Gly Val Pro Ile Val Trp Met Trp Lys Ser
            1300                1305                1310        
 Leu Arg Lys Gly Leu Glu Val Glu Glu Lys Arg Ala Ser Glu Ile Cys
        1315                1320                1325            
 His Arg Gly Cys Thr Cys Lys Asp Gly Gln Val Val Ser Gly Pro Glu
    1330                1335                1340                
 Val Leu Leu Gly Glu Glu Cys Ser Gly Tyr Gly Ala Glu Ser Gly Ser
1345                1350                1355                1360
 Trp Leu Ser Pro Ser Arg Lys Lys Asn Gly Val Gln Gly His Glu Ser
                1365                1370                1375    
 Ser Ala Ser Asp Thr Cys Ser Tyr Gln Arg Val Leu Ser Arg Pro Ile
            1380                1385                1390        
 Ile Pro Ser Ser Lys Ser Gln Gly Ala Trp Met Glu Glu Tyr Gln Val
        1395                1400                1405            
 Leu Asp Val Gln Pro Arg Gly Ser Pro Gly Val Asp Thr Leu Asp Leu
    1410                1415                1420                
 Ala Leu Gly Pro Val Trp Thr His Cys Gly Ser Ser Ser Pro Gly Pro
1425                1430                1435                1440





      <210> 1457
      <211> 2208
      <212> PRT
      <213> Homo sapiens


      <400> 1457
 Met Val Ile Arg Cys Leu Pro Gln Arg Glu Leu Asp Cys Asp Arg Gly
   1               5                  10                  15    
 Asn Trp Thr Ala Thr Ser Ala Glu Leu Thr Gly Ile Lys Trp Arg Arg
              20                  25                  30        
 Tyr Asn Phe Gly Gly His Gly Asp Cys Gly Pro Ile Ile Ser Ala Pro
          35                  40                  45            
 Ala Gln Asp Asp Pro Ile Leu Leu Ser Phe Ile Arg Cys Leu Gln Ala
      50                  55                  60                
 Asn Leu Leu Cys Val Trp Arg Arg Asp Val Lys Pro Asp Cys Lys Glu
  65                  70                  75                  80
 Leu Trp Ile Phe Trp Trp Gly Asp Glu Pro Asn Leu Val Gly Val Ile
                  85                  90                  95    
 His His Glu Leu Gln Val Val Glu Glu Gly Leu Trp Glu Asn Gly Leu
             100                 105                 110        
 Ser Tyr Glu Cys Arg Thr Leu Leu Phe Lys Ala Ile His Asn Leu Leu
         115                 120                 125            
 Glu Arg Cys Leu Met Asp Lys Asn Phe Val Arg Ile Gly Lys Trp Phe
     130                 135                 140                
 Val Arg Pro Tyr Glu Lys Asp Glu Lys Pro Val Asn Lys Ser Glu His
 145                 150                 155                 160
 Leu Ser Cys Ala Phe Thr Phe Phe Leu His Gly Glu Ser Asn Val Cys
                 165                 170                 175    
 Thr Ser Val Glu Ile Ala Gln His Gln Pro Ile Tyr Leu Ile Asn Glu
             180                 185                 190        
 Glu His Ile His Met Ala Gln Ser Ser Pro Ala Pro Phe Gln Val Leu
         195                 200                 205            
 Val Ser Pro Tyr Gly Leu Asn Gly Thr Leu Thr Gly Gln Ala Tyr Lys
     210                 215                 220                
 Met Ser Asp Pro Ala Thr Arg Lys Leu Ile Glu Glu Trp Gln Tyr Phe
 225                 230                 235                 240
 Tyr Pro Met Val Leu Lys Lys Lys Glu Glu Ser Lys Glu Glu Asp Glu
                 245                 250                 255    
 Leu Gly Tyr Asp Asp Asp Phe Pro Val Ala Val Glu Val Ile Val Gly
             260                 265                 270        
 Gly Val Arg Met Val Tyr Pro Ser Ala Phe Val Leu Ile Ser Gln Asn
         275                 280                 285            
 Asp Ile Pro Val Pro Gln Ser Val Ala Ser Ala Gly Gly His Ile Ala
     290                 295                 300                
 Val Gly Gln Gln Gly Leu Gly Ser Val Lys Asp Pro Ser Asn Cys Gly
 305                 310                 315                 320
 Met Pro Leu Thr Pro Pro Thr Ser Pro Glu Gln Ala Ile Leu Gly Glu
                 325                 330                 335    
 Ser Gly Gly Met Gln Ser Ala Ala Ser His Leu Val Ser Gln Asp Gly
             340                 345                 350        
 Gly Met Ile Thr Met His Ser Pro Lys Arg Ser Gly Lys Ile Pro Pro
         355                 360                 365            
 Lys Leu His Asn His Met Val His Arg Val Trp Lys Glu Cys Ile Leu
     370                 375                 380                
 Asn Arg Thr Gln Ser Lys Arg Ser Gln Met Ser Thr Pro Thr Leu Glu
 385                 390                 395                 400
 Glu Glu Pro Ala Ser Asn Pro Ala Thr Trp Asp Phe Val Asp Pro Thr
                 405                 410                 415    
 Gln Arg Val Ser Cys Ser Cys Ser Arg His Lys Leu Leu Lys Arg Cys
             420                 425                 430        
 Ala Val Gly Pro Asn Arg Pro Pro Thr Val Ser Gln Pro Gly Phe Ser
         435                 440                 445            
 Ala Gly Pro Ser Ser Ser Ser Ser Leu Pro Pro Pro Ala Ser Ser Lys
     450                 455                 460                
 His Lys Thr Ala Glu Arg Gln Glu Lys Gly Asp Lys Leu Gln Lys Arg
 465                 470                 475                 480
 Pro Leu Ile Pro Phe His His Arg Pro Ser Val Ala Glu Glu Leu Cys
                 485                 490                 495    
 Met Glu Gln Asp Thr Pro Gly Gln Lys Leu Gly Leu Ala Gly Ile Asp
             500                 505                 510        
 Ser Ser Leu Glu Val Ser Ser Ser Arg Lys Tyr Asp Lys Gln Met Ala
         515                 520                 525            
 Val Pro Ser Arg Asn Thr Ser Lys Gln Met Asn Leu Asn Pro Met Asp
     530                 535                 540                
 Ser Pro His Ser Pro Ile Ser Pro Leu Pro Pro Thr Leu Ser Pro Gln
 545                 550                 555                 560
 Pro Arg Gly Gln Glu Thr Glu Ser Leu Asp Pro Pro Ser Val Pro Val
                 565                 570                 575    
 Asn Pro Ala Leu Tyr Gly Asn Gly Leu Glu Leu Gln Gln Leu Ser Thr
             580                 585                 590        
 Leu Asp Asp Arg Thr Val Leu Val Gly Gln Arg Leu Pro Leu Met Ala
         595                 600                 605            
 Glu Val Ser Glu Thr Ala Leu Tyr Cys Gly Ile Arg Pro Ser Asn Pro
     610                 615                 620                
 Glu Ser Ser Glu Lys Trp Trp His Ser Tyr Arg Leu Pro Pro Ser Asp
 625                 630                 635                 640
 Asp Ala Glu Phe Arg Pro Pro Glu Leu Gln Gly Glu Arg Cys Asp Ala
                 645                 650                 655    
 Lys Met Glu Val Asn Ser Glu Ser Thr Ala Leu Gln Arg Leu Leu Ala
             660                 665                 670        
 Gln Pro Asn Lys Arg Phe Lys Ile Trp Gln Asp Lys Gln Pro Gln Leu
         675                 680                 685            
 Gln Pro Leu His Phe Leu Asp Pro Leu Pro Leu Ser Gln Gln Pro Gly
     690                 695                 700                
 Asp Ser Leu Gly Glu Val Asn Asp Pro Tyr Thr Phe Glu Asp Gly Asp
 705                 710                 715                 720
 Ile Lys Tyr Ile Phe Thr Ala Asn Lys Lys Cys Lys Gln Gly Thr Glu
                 725                 730                 735    
 Lys Asp Ser Leu Lys Lys Asn Lys Ser Glu Asp Gly Phe Gly Thr Lys
             740                 745                 750        
 Asp Val Thr Thr Pro Gly His Ser Thr Pro Val Pro Asp Gly Lys Asn
         755                 760                 765            
 Ala Met Ser Ile Phe Ser Ser Ala Thr Lys Thr Asp Val Arg Gln Asp
     770                 775                 780                
 Asn Ala Ala Gly Arg Ala Gly Ser Ser Ser Leu Thr Gln Val Thr Asp
 785                 790                 795                 800
 Leu Ala Pro Ser Leu His Asp Leu Asp Asn Ile Phe Asp Asn Ser Asp
                 805                 810                 815    
 Asp Asp Glu Leu Gly Ala Val Ser Pro Ala Leu Arg Ser Ser Lys Met
             820                 825                 830        
 Pro Ala Val Gly Thr Glu Asp Arg Pro Leu Gly Lys Asp Gly Arg Ala
         835                 840                 845            
 Ala Val Pro Tyr Pro Pro Thr Val Ala Asp Leu Gln Arg Met Phe Pro
     850                 855                 860                
 Thr Pro Pro Ser Leu Glu Gln His Pro Ala Phe Ser Pro Val Met Asn
 865                 870                 875                 880
 Tyr Lys Asp Gly Ile Ser Ser Glu Thr Val Thr Ala Leu Gly Met Met
                 885                 890                 895    
 Glu Ser Pro Met Val Ser Met Val Ser Thr Gln Leu Thr Glu Phe Lys
             900                 905                 910        
 Met Glu Val Glu Asp Gly Leu Gly Ser Pro Lys Pro Glu Glu Ile Lys
         915                 920                 925            
 Asp Phe Ser Tyr Val His Lys Val Pro Ser Phe Gln Pro Phe Val Gly
     930                 935                 940                
 Ser Ser Met Phe Ala Pro Leu Lys Met Leu Pro Ser His Cys Leu Leu
 945                 950                 955                 960
 Pro Leu Lys Ile Pro Asp Ala Cys Leu Phe Arg Pro Ser Trp Ala Ile
                 965                 970                 975    
 Pro Pro Lys Ile Glu Gln Leu Pro Met Pro Pro Ala Ala Thr Phe Ile
             980                 985                 990        
 Arg Asp Gly Tyr Asn Asn Val Pro Ser Val Gly Ser Leu Ala Asp Pro
         995                1000                1005            
 Asp Tyr Leu Asn Thr Pro Gln Met Asn Thr Pro Val Thr Leu Asn Ser
    1010                1015                1020                
 Ala Ala Pro Ala Ser Asn Ser Gly Ala Gly Val Leu Pro Ser Pro Ala
1025                1030                1035                1040
 Thr Pro Arg Phe Ser Val Pro Thr Pro Arg Thr Pro Arg Thr Pro Arg
                1045                1050                1055    
 Thr Pro Arg Gly Gly Gly Thr Ala Ser Gly Gln Gly Ser Val Lys Tyr
            1060                1065                1070        
 Asp Ser Thr Asp Gln Gly Ser Pro Ala Ser Thr Pro Ser Thr Thr Arg
        1075                1080                1085            
 Pro Leu Asn Ser Val Glu Pro Ala Thr Met Gln Pro Ile Pro Glu Ala
    1090                1095                1100                
 His Ser Leu Tyr Val Thr Leu Ile Leu Ser Asp Ser Val Met Asn Ile
1105                1110                1115                1120
 Phe Lys Asp Arg Asn Phe Asp Ser Cys Cys Ile Cys Ala Cys Asn Met
                1125                1130                1135    
 Asn Ile Lys Gly Ala Asp Val Gly Leu Tyr Ile Pro Asp Ser Ser Asn
            1140                1145                1150        
 Glu Asp Gln Tyr Arg Cys Thr Cys Gly Phe Ser Ala Ile Met Asn Arg
        1155                1160                1165            
 Lys Leu Gly Tyr Asn Ser Gly Leu Phe Leu Glu Asp Glu Leu Asp Ile
    1170                1175                1180                
 Phe Gly Lys Asn Ser Asp Ile Gly Gln Ala Ala Glu Arg Arg Leu Met
1185                1190                1195                1200
 Met Cys Gln Ser Thr Phe Leu Pro Gln Val Glu Gly Thr Lys Lys Pro
                1205                1210                1215    
 Gln Glu Pro Pro Ile Ser Leu Leu Leu Leu Leu Gln Asn Gln His Thr
            1220                1225                1230        
 Gln Pro Phe Ala Ser Leu Asn Phe Leu Asp Tyr Ile Ser Ser Asn Asn
        1235                1240                1245            
 Arg Gln Thr Leu Pro Cys Val Ser Trp Ser Tyr Asp Arg Val Gln Ala
    1250                1255                1260                
 Asp Asn Asn Asp Tyr Trp Thr Glu Cys Phe Asn Ala Leu Glu Gln Gly
1265                1270                1275                1280
 Arg Gln Tyr Val Asp Asn Pro Thr Gly Gly Lys Val Asp Glu Ala Leu
                1285                1290                1295    
 Val Arg Ser Ala Thr Val His Ser Trp Pro His Ser Asn Val Leu Asp
            1300                1305                1310        
 Ile Ser Met Leu Ser Ser Gln Asp Val Val Arg Met Leu Leu Ser Leu
        1315                1320                1325            
 Gln Pro Phe Leu Gln Asp Ala Ile Gln Lys Lys Arg Thr Gly Arg Thr
    1330                1335                1340                
 Trp Glu Asn Ile Gln His Val Gln Gly Pro Leu Thr Trp Gln Gln Phe
1345                1350                1355                1360
 His Lys Met Ala Gly Arg Gly Thr Tyr Gly Ser Glu Glu Ser Pro Glu
                1365                1370                1375    
 Pro Leu Pro Ile Pro Thr Leu Leu Val Gly Tyr Asp Lys Asp Phe Leu
            1380                1385                1390        
 Thr Ile Ser Pro Phe Ser Leu Pro Phe Trp Glu Arg Leu Leu Leu Asp
        1395                1400                1405            
 Pro Tyr Gly Gly His Arg Asp Val Ala Tyr Ile Val Val Cys Pro Glu
    1410                1415                1420                
 Asn Glu Ala Leu Leu Glu Gly Ala Lys Thr Phe Phe Arg Asp Leu Ser
1425                1430                1435                1440
 Ala Val Tyr Glu Met Cys Arg Leu Gly Gln His Lys Pro Ile Cys Lys
                1445                1450                1455    
 Val Leu Arg Asp Gly Ile Met Arg Val Gly Lys Thr Val Ala Gln Lys
            1460                1465                1470        
 Leu Thr Asp Glu Leu Val Ser Glu Trp Phe Asn Gln Pro Trp Ser Gly
        1475                1480                1485            
 Glu Glu Asn Asp Asn His Ser Arg Leu Lys Leu Tyr Ala Gln Val Cys
    1490                1495                1500                
 Arg His His Leu Ala Pro Tyr Leu Ala Thr Leu Gln Leu Asp Ser Ser
1505                1510                1515                1520
 Leu Leu Ile Pro Pro Lys Tyr Gln Thr Pro Pro Ala Ala Ala Gln Gly
                1525                1530                1535    
 Gln Ala Thr Pro Gly Asn Ala Gly Pro Leu Ala Pro Asn Gly Ser Ala
            1540                1545                1550        
 Ala Pro Pro Ala Gly Ser Ala Phe Asn Pro Thr Ser Asn Ser Ser Ser
        1555                1560                1565            
 Thr Asn Pro Ala Ala Ser Ser Ser Ala Ser Gly Ser Ser Val Pro Pro
    1570                1575                1580                
 Val Ser Ser Ser Ala Ser Ala Pro Gly Ile Ser Gln Ile Ser Thr Thr
1585                1590                1595                1600
 Ser Ser Ser Gly Phe Ser Gly Ser Val Gly Gly Gln Asn Pro Ser Thr
                1605                1610                1615    
 Gly Gly Ile Ser Ala Asp Arg Thr Gln Gly Asn Ile Gly Cys Gly Gly
            1620                1625                1630        
 Asp Thr Asp Pro Gly Gln Ser Ser Ser Gln Pro Ser Gln Asp Gly Gln
        1635                1640                1645            
 Glu Ser Val Thr Glu Arg Glu Arg Ile Gly Ile Pro Thr Glu Pro Asp
    1650                1655                1660                
 Ser Ala Asp Ser His Ala His Pro Pro Ala Val Val Ile Tyr Met Val
1665                1670                1675                1680
 Asp Pro Phe Thr Tyr Ala Ala Glu Glu Asp Ser Thr Ser Gly Asn Phe
                1685                1690                1695    
 Trp Leu Leu Ser Leu Met Arg Cys Tyr Thr Glu Met Leu Asp Asn Leu
            1700                1705                1710        
 Pro Glu His Met Arg Asn Ser Phe Ile Leu Gln Ile Val Pro Cys Gln
        1715                1720                1725            
 Tyr Met Leu Gln Thr Met Lys Asp Glu Gln Val Phe Tyr Ile Gln Tyr
    1730                1735                1740                
 Leu Lys Ser Met Ala Phe Ser Val Tyr Cys Gln Cys Arg Arg Pro Leu
1745                1750                1755                1760
 Pro Thr Gln Ile His Ile Lys Ser Leu Thr Gly Phe Gly Pro Ala Ala
                1765                1770                1775    
 Ser Ile Glu Met Thr Leu Lys Asn Pro Glu Arg Pro Ser Pro Ile Gln
            1780                1785                1790        
 Leu Tyr Ser Pro Pro Phe Ile Leu Ala Pro Ile Lys Asp Lys Gln Thr
        1795                1800                1805            
 Glu Leu Gly Glu Thr Phe Gly Glu Ala Ser Gln Lys Tyr Asn Val Leu
    1810                1815                1820                
 Phe Val Gly Tyr Cys Leu Ser His Asp Gln Arg Trp Leu Leu Ala Ser
1825                1830                1835                1840
 Cys Thr Asp Leu His Gly Glu Leu Leu Glu Thr Cys Val Val Asn Ile
                1845                1850                1855    
 Ala Leu Pro Asn Arg Ser Arg Arg Ser Lys Val Ser Ala Arg Lys Ile
            1860                1865                1870        
 Gly Leu Gln Lys Leu Trp Glu Trp Cys Ile Gly Ile Val Gln Met Thr
        1875                1880                1885            
 Ser Leu Pro Trp Arg Val Val Ile Gly Arg Leu Gly Arg Leu Gly His
    1890                1895                1900                
 Gly Glu Leu Lys Asp Trp Ser Ile Leu Leu Gly Glu Cys Ser Leu Gln
1905                1910                1915                1920
 Thr Ile Ser Lys Lys Leu Lys Asp Val Cys Arg Met Cys Gly Ile Ser
                1925                1930                1935    
 Ala Ala Asp Ser Pro Ser Ile Leu Ser Ala Cys Leu Val Ala Met Glu
            1940                1945                1950        
 Pro Gln Gly Ser Phe Val Val Met Pro Asp Ala Val Thr Met Gly Ser
        1955                1960                1965            
 Val Phe Gly Arg Ser Thr Ala Leu Asn Met Gln Ser Ser Gln Leu Asn
    1970                1975                1980                
 Thr Pro Gln Asp Ala Ser Cys Thr His Ile Leu Val Phe Pro Thr Ser
1985                1990                1995                2000
 Ser Thr Ile Gln Val Ala Pro Ala Asn Tyr Pro Asn Glu Asp Gly Phe
                2005                2010                2015    
 Ser Pro Asn Asn Asp Asp Met Phe Val Asp Leu Pro Phe Pro Asp Asp
            2020                2025                2030        
 Met Asp Asn Asp Ile Gly Ile Leu Met Thr Gly Asn Leu His Ser Ser
        2035                2040                2045            
 Pro Asn Ser Ser Pro Val Pro Ser Pro Gly Ser Pro Ser Gly Ile Gly
    2050                2055                2060                
 Val Gly Ser His Phe Gln His Ser Arg Ser Gln Gly Glu Arg Leu Leu
2065                2070                2075                2080
 Ser Arg Glu Ala Pro Glu Glu Leu Lys Gln Gln Pro Leu Ala Leu Gly
                2085                2090                2095    
 Tyr Phe Val Ser Thr Ala Lys Ala Glu Asn Leu Pro Gln Trp Phe Trp
            2100                2105                2110        
 Ser Ser Cys Pro Gln Ala Gln Asn Gln Cys Pro Leu Phe Leu Lys Ala
        2115                2120                2125            
 Ser Leu His His His Ile Ser Val Ala Gln Thr Asp Glu Leu Leu Pro
    2130                2135                2140                
 Ala Arg Asn Ser Gln Arg Val Pro His Pro Leu Asp Ser Lys Thr Thr
2145                2150                2155                2160
 Ser Asp Val Leu Arg Phe Val Leu Glu Gln Tyr Asn Ala Leu Ser Trp
                2165                2170                2175    
 Leu Thr Cys Asn Pro Ala Thr Gln Asp Arg Thr Ser Cys Leu Pro Val
            2180                2185                2190        
 His Phe Val Val Leu Thr Gln Leu Tyr Asn Ala Ile Met Asn Ile Leu
        2195                2200                2205            





      <210> 1458
      <211> 738
      <212> PRT
      <213> Homo sapiens


      <400> 1458
 Met Ala Ala Lys Lys Ile Leu Tyr Asp Trp Ala Ala Gly Lys Leu Tyr
   1               5                  10                  15    
 Gln Gly Gln Val Asp Phe Ala Phe Phe Met Pro Cys Gly Glu Leu Leu
              20                  25                  30        
 Glu Arg Pro Gly Thr Arg Ser Leu Ala Asp Leu Ile Leu Asp Gln Cys
          35                  40                  45            
 Pro Asp Arg Gly Ala Pro Val Pro Gln Met Leu Ala Gln Pro Gln Arg
      50                  55                  60                
 Leu Leu Phe Ile Leu Asp Gly Ala Asp Glu Leu Pro Ala Leu Gly Gly
  65                  70                  75                  80
 Pro Glu Ala Ala Pro Cys Thr Asp Pro Phe Glu Ala Ala Ser Gly Ala
                  85                  90                  95    
 Arg Val Leu Gly Gly Leu Leu Ser Lys Ala Leu Leu Pro Thr Ala Leu
             100                 105                 110        
 Leu Leu Val Thr Thr Arg Ala Ala Ala Pro Gly Arg Leu Gln Gly Arg
         115                 120                 125            
 Leu Cys Ser Pro Gln Cys Ala Glu Val Arg Gly Phe Ser Asp Lys Asp
     130                 135                 140                
 Lys Lys Lys Tyr Phe Tyr Lys Phe Phe Arg Asp Glu Arg Arg Ala Glu
 145                 150                 155                 160
 Arg Ala Tyr Arg Phe Val Lys Glu Asn Glu Thr Leu Phe Ala Leu Cys
                 165                 170                 175    
 Phe Val Pro Phe Val Cys Trp Ile Val Cys Thr Val Leu Arg Gln Gln
             180                 185                 190        
 Leu Glu Leu Gly Arg Asp Leu Ser Arg Thr Ser Lys Thr Thr Thr Ser
         195                 200                 205            
 Val Tyr Leu Leu Phe Ile Thr Ser Val Leu Ser Ser Ala Pro Val Ala
     210                 215                 220                
 Asp Gly Pro Arg Leu Gln Gly Asp Leu Arg Asn Leu Cys Arg Leu Ala
 225                 230                 235                 240
 Arg Glu Gly Val Leu Gly Arg Arg Ala Gln Phe Ala Glu Lys Glu Leu
                 245                 250                 255    
 Glu Gln Leu Glu Leu Arg Gly Ser Lys Val Gln Thr Leu Phe Leu Ser
             260                 265                 270        
 Lys Lys Glu Leu Pro Gly Val Leu Glu Thr Glu Val Thr Tyr Gln Phe
         275                 280                 285            
 Ile Asp Gln Ser Phe Gln Glu Phe Leu Ala Ala Leu Ser Tyr Leu Leu
     290                 295                 300                
 Glu Asp Gly Gly Val Pro Arg Thr Ala Ala Gly Gly Val Gly Thr Leu
 305                 310                 315                 320
 Leu Arg Gly Asp Ala Gln Pro His Ser His Leu Val Leu Thr Thr Arg
                 325                 330                 335    
 Phe Leu Phe Gly Leu Leu Ser Ala Glu Arg Met Arg Asp Ile Glu Arg
             340                 345                 350        
 His Phe Gly Cys Met Val Ser Glu Arg Val Lys Gln Glu Ala Leu Arg
         355                 360                 365            
 Trp Val Gln Gly Gln Gly Gln Gly Cys Pro Gly Val Ala Pro Glu Val
     370                 375                 380                
 Thr Glu Gly Ala Lys Gly Leu Glu Asp Thr Glu Glu Pro Glu Glu Glu
 385                 390                 395                 400
 Glu Glu Gly Glu Glu Pro Asn Tyr Pro Leu Glu Leu Leu Tyr Cys Leu
                 405                 410                 415    
 Tyr Glu Thr Gln Glu Asp Ala Phe Val Arg Gln Ala Leu Cys Arg Phe
             420                 425                 430        
 Pro Glu Leu Ala Leu Gln Arg Val Arg Phe Cys Arg Met Asp Val Ala
         435                 440                 445            
 Val Leu Ser Tyr Cys Val Arg Cys Cys Pro Ala Gly Gln Ala Leu Arg
     450                 455                 460                
 Leu Ile Ser Cys Arg Leu Val Ala Ala Gln Glu Lys Lys Lys Lys Ser
 465                 470                 475                 480
 Leu Gly Lys Arg Leu Gln Ala Ser Leu Gly Gly Gly Ser Trp Leu Gly
                 485                 490                 495    
 Thr Gln Leu Ala Pro Glu Val Pro Phe Arg Pro Pro Cys Cys Asp Ile
             500                 505                 510        
 Cys Pro Thr Pro Pro Pro Asp Pro Arg Leu Leu Gln Gly Lys Ala Phe
         515                 520                 525            
 Ala Arg Val Pro Leu Asn Ile Ala Pro Ile Gln Pro Leu Pro Arg Gly
     530                 535                 540                
 Leu Ala Ser Val Glu Arg Met Asn Val Thr Val Leu Ala Gly Ala Gly
 545                 550                 555                 560
 Pro Gly Asp Pro Lys Thr His Ala Met Thr Asp Pro Leu Cys His Leu
                 565                 570                 575    
 Ser Ser Leu Thr Leu Ser His Cys Lys Leu Pro Asp Ala Val Cys Arg
             580                 585                 590        
 Asp Leu Ser Glu Ala Leu Arg Ala Ala Pro Ala Leu Thr Glu Leu Gly
         595                 600                 605            
 Leu Leu His Asn Arg Leu Ser Glu Ala Gly Leu Arg Met Leu Ser Glu
     610                 615                 620                
 Gly Leu Ala Trp Pro Gln Cys Arg Val Gln Thr Val Arg Val Gln Leu
 625                 630                 635                 640
 Pro Asp Pro Gln Arg Gly Leu Gln Tyr Leu Val Gly Met Leu Arg Gln
                 645                 650                 655    
 Ser Pro Ala Leu Thr Thr Leu Asp Leu Ser Gly Cys Gln Leu Pro Ala
             660                 665                 670        
 Pro Met Val Thr Tyr Leu Cys Ala Val Leu Gln His Gln Gly Cys Gly
         675                 680                 685            
 Leu Gln Thr Leu Ser Leu Ala Ser Val Glu Leu Ser Glu Gln Ser Leu
     690                 695                 700                
 Gln Glu Leu Gln Ala Val Lys Arg Ala Lys Pro Asp Leu Val Ile Ala
 705                 710                 715                 720
 His Pro Ala Leu Asp Gly His Pro Gln Pro Pro Lys Glu Leu Ile Ser
                 725                 730                 735    
 Thr Phe
        



      <210> 1459
      <211> 617
      <212> PRT
      <213> Homo sapiens


      <400> 1459
 Met Ala His Arg Gly Gly Glu Arg Asp Phe Gln Thr Ser Ala Arg Arg
   1               5                  10                  15    
 Met Gly Thr Ser Leu Leu Phe Gln Leu Ser Val His Glu Arg Glu Leu
              20                  25                  30        
 Asp Leu Val Phe Leu Asp His Ser Tyr Ala Lys Pro Trp Ser Ala His
          35                  40                  45            
 Pro Asp Ala Ser Ser Ala Arg Pro Thr Arg Met Leu Phe Val Thr Pro
      50                  55                  60                
 Arg Arg Gln His Glu Ser Thr Ile Glu Ser Asp Val Pro Ile Asp Val
  65                  70                  75                  80
 Glu Thr Val Thr Ser Thr Pro Met Pro Leu Tyr Asp Asn Gln Lys Ala
                  85                  90                  95    
 Arg Ser Val Met Asn Glu Cys Glu Arg His Val Ile Phe Ala Arg Thr
             100                 105                 110        
 Asp Ala Asp Ala Pro Pro Pro Pro Glu Asp Trp Glu Glu His Val Asn
         115                 120                 125            
 Arg Thr Gly Trp Thr Met Ala Gln Asn Lys Leu Phe Asn Lys Ile Leu
     130                 135                 140                
 Lys Ala Leu Gln Ser Asp Arg Leu Ala Arg Leu Ala Asn Glu Gly Ala
 145                 150                 155                 160
 Cys Asn Glu Pro Val Leu Arg Arg Val Ala Val Asp Lys Cys Ala Arg
                 165                 170                 175    
 Arg Val Arg Gln Ala Leu Ala Ser Val Ser Trp Asp Thr Lys Leu Ile
             180                 185                 190        
 Gln Trp Leu His Thr Thr Leu Val Glu Thr Leu Ser Leu Pro Met Leu
         195                 200                 205            
 Ala Ala Tyr Leu Asp Ala Leu Gln Thr Leu Lys Gly Lys Ile Pro Thr
     210                 215                 220                
 Leu Ile Asp Arg Met Leu Val Ser Ser Asn Thr Lys Thr Gly Ala Ala
 225                 230                 235                 240
 Gly Ala Glu Ala Leu Ser Leu Leu Leu Lys Arg Pro Trp Asp Pro Ala
                 245                 250                 255    
 Val Gly Val Leu Ser His Asn Lys Pro Ser Lys Leu Pro Gly Ser Pro
             260                 265                 270        
 Leu Ile Leu Ile Ala Ser Ser Gly Pro Ser Ser Ser Val Phe Pro Thr
         275                 280                 285            
 Ser Arg Arg His Arg Phe Trp Gln Ser Gln Leu Ser Cys Leu Gly Lys
     290                 295                 300                
 Val Ile Pro Val Ala Thr His Leu Leu Asn Asn Gly Ser Gly Val Gly
 305                 310                 315                 320
 Val Leu Gln Cys Leu Glu His Met Ile Gly Ala Val Arg Ser Lys Val
                 325                 330                 335    
 Leu Glu Ile His Ser His Phe Pro His Lys Pro Ile Ile Leu Ile Gly
             340                 345                 350        
 Trp Asn Thr Gly Ala Leu Val Ala Cys His Val Ser Val Met Glu Tyr
         355                 360                 365            
 Val Thr Ala Val Val Cys Leu Gly Phe Pro Leu Leu Thr Val Asp Gly
     370                 375                 380                
 Pro Arg Gly Asp Val Asp Asp Pro Leu Leu Asp Met Lys Thr Pro Val
 385                 390                 395                 400
 Leu Phe Val Ile Gly Gln Asn Ser Leu Gln Cys His Pro Glu Ala Met
                 405                 410                 415    
 Glu Asp Phe Arg Glu Lys Ile Arg Ala Glu Asn Ser Leu Val Val Val
             420                 425                 430        
 Gly Gly Ala Asp Asp Asn Leu Arg Ile Ser Lys Ala Lys Lys Lys Ser
         435                 440                 445            
 Glu Gly Leu Thr Gln Ser Met Val Asp Arg Cys Ile Gln Asp Glu Ile
     450                 455                 460                
 Val Asp Phe Leu Thr Gly Val Leu Thr Arg Ala Glu Gly His Met Gly
 465                 470                 475                 480
 Ser Glu Pro Arg Asp Gln Asp Ala Glu Lys Lys Lys Lys Pro Arg Asp
                 485                 490                 495    
 Val Ala Arg Arg Asp Leu Ala Phe Glu Val Pro Glu Arg Gly Ser Arg
             500                 505                 510        
 Pro Ala Ser Pro Ala Ala Lys Leu Pro Ala Ser Pro Ser Gly Ser Glu
         515                 520                 525            
 Gly Leu Ser Ser Val Ser Ser Ser Pro Thr Ser Ser Pro Lys Thr Lys
     530                 535                 540                
 Val Thr Thr Val Thr Ser Ala Gln Lys Ser Ser Gln Ile Gly Ser Ser
 545                 550                 555                 560
 Gln Leu Leu Lys Arg His Val Gln Arg Thr Glu Ala Val Leu Thr His
                 565                 570                 575    
 Lys Gln Ala Gln Val Pro Ile Ser Ser Glu Pro Pro Glu Glu Gly Glu
             580                 585                 590        
 Lys Glu Asp Leu Arg Val Gln Leu Lys Arg His His Pro Ser Ser Pro
         595                 600                 605            
 Leu Pro Val Tyr Ser Trp Phe His His
     610                 615        



      <210> 1460
      <211> 266
      <212> PRT
      <213> Homo sapiens


      <400> 1460
 Met His Ser Ser Leu Lys Pro Thr Gln Pro Trp Gly Leu Gln Ala Ser
   1               5                  10                  15    
 Ser Ser Arg Val Pro Ser Leu Val Leu Ala Ala Ala Leu Leu Pro Leu
              20                  25                  30        
 Gln Ala Pro Ser Arg Thr Leu Ala Leu Ala Pro Ser Arg Gly Leu His
          35                  40                  45            
 Pro Leu Pro Thr Val Pro Ser Trp Val Val Pro Arg Ser Leu Ser Pro
      50                  55                  60                
 Leu Pro Trp Thr Pro Leu Pro Leu Thr Gly Arg Ser Ile Glu Phe Asn
  65                  70                  75                  80
 Ala Pro Gly Gly Leu His Val His Pro Thr Gly Thr Arg Thr Leu Ile
                  85                  90                  95    
 Phe Leu Leu Ser Val Leu Ser Pro Glu Thr Trp His Trp Asn Ser Pro
             100                 105                 110        
 Cys His Leu Val Val Ser Pro Ser Gly Asn Leu Gly Val Ser Leu Asp
         115                 120                 125            
 Ala Cys His Gln Ile Leu Ser Leu Pro Pro Ser His Gly Leu Ser Ile
     130                 135                 140                
 Phe Thr Ala Ser Val Ser Leu Ser Arg Pro Asp His Arg Arg Leu Ser
 145                 150                 155                 160
 Ser Gly Gly Glu His Gln His Ser His Trp Ser Leu Leu Phe Leu Lys
                 165                 170                 175    
 Arg Ile Ser Val Tyr Ile Ser Pro Gln Asp His Ser Val Ala Pro Thr
             180                 185                 190        
 Ala Leu Gly Gly Thr Phe Phe Pro Val Val Phe Gln Ser Pro Gly Ser
         195                 200                 205            
 Ala Ser Leu Leu Thr Thr Val Leu Cys Phe Cys Thr Glu Leu Gln Pro
     210                 215                 220                
 Asp His Leu Pro Ala Ala Thr Trp His Tyr Leu Phe Pro Cys Ala Ser
 225                 230                 235                 240
 Cys Leu Cys Leu Glu Arg Ile Thr Ile Tyr Ser Pro Asn Ser Arg Thr
                 245                 250                 255    
 Lys Thr Asn Cys Phe Leu Ala Val Val Ala
             260                 265    



      <210> 1461
      <211> 128
      <212> PRT
      <213> Homo sapiens


      <400> 1461
 Met Leu Val Ser Asn Leu Lys Arg Gln Phe Lys Leu Phe Tyr Lys Ile
   1               5                  10                  15    
 Arg Tyr Leu Ile Phe Gly Ser Asp Met Trp Glu Gly Gly Arg Leu Tyr
              20                  25                  30        
 Ile Phe Gly Leu Leu Pro Phe Cys His Ile Lys Leu Gln Ile Asp Phe
          35                  40                  45            
 Ile Phe Val Val Phe Val Asp Gly Gly Glu Tyr Tyr Lys Ile Asp Gln
      50                  55                  60                
 Phe Ser Met Ser Gly Asn Glu Glu Val Pro Trp Ser Met Leu Gln Pro
  65                  70                  75                  80
 Gly Ser Trp Lys Lys Ser Leu Gln Ala Cys Ile Ala Asn Ser His Ser
                  85                  90                  95    
 His Thr Asp Leu Ala Gln Phe Ala Val Leu Leu Tyr Ala Met Ile Cys
             100                 105                 110        
 Ile Asn Asp Thr Gly Gln Gly Arg Ser Arg Asn Arg Asn Glu Asp Met
         115                 120                 125            





      <210> 1462
      <211> 463
      <212> PRT
      <213> Homo sapiens


      <400> 1462
 Met Asp Lys Gly Phe Pro Gln Arg Val Val Lys His Phe Pro Gly Ile
   1               5                  10                  15    
 Ser Ile Arg Val Asp Ala Ala Phe Gln Tyr Lys Ala His Gly Asp Ser
              20                  25                  30        
 Tyr Pro Phe Asp Gly Pro Gly Asn Thr Leu Ala His Ala Phe Ala Pro
          35                  40                  45            
 Gly Thr Gly Leu Gly Gly Asp Ala His Phe Asp Glu Asp Glu Arg Trp
      50                  55                  60                
 Thr Asp Gly Ser Ser Leu Glu Gly Asn His Leu Val Gln Ser Asn Asn
  65                  70                  75                  80
 Arg Ser Phe Ile Asp Asp Lys Ile Arg Glu Met Gln Ala Phe Phe Gly
                  85                  90                  95    
 Leu Thr Val Thr Gly Lys Leu Asp Ser Asn Thr Leu Glu Ile Met Lys
             100                 105                 110        
 Thr Pro Arg Cys Gly Val Pro Asp Val Gly Gln Tyr Gly Tyr Thr Leu
         115                 120                 125            
 Pro Gly Trp Arg Lys Tyr Asn Leu Thr Tyr Arg Ile Ile Asn Tyr Thr
     130                 135                 140                
 Pro Asp Met Ala Arg Ala Ala Val Asp Glu Ala Ile Gln Glu Gly Leu
 145                 150                 155                 160
 Glu Val Trp Ser Lys Val Thr Pro Leu Lys Phe Thr Lys Ile Ser Lys
                 165                 170                 175    
 Gly Ile Ala Asp Ile Met Ile Ala Phe Arg Thr Arg Val His Gly Arg
             180                 185                 190        
 Cys Pro Arg Tyr Phe Asp Gly Pro Leu Gly Val Leu Gly His Ala Phe
         195                 200                 205            
 Pro Pro Gly Pro Gly Leu Gly Gly Asp Thr His Phe Asp Glu Asp Glu
     210                 215                 220                
 Asn Trp Thr Lys Asp Gly Ala Gly Phe Asn Leu Phe Leu Val Ala Ala
 225                 230                 235                 240
 His Glu Phe Gly His Ala Leu Gly Leu Ser His Ser Ser Asp Pro Gly
                 245                 250                 255    
 Ala Leu Met Tyr Pro Asn Tyr Ala Phe Arg Glu Thr Ser Asn Tyr Ser
             260                 265                 270        
 Leu Pro Gln Asp Asp Ile Asp Gly Ile Gln Ala Ile Tyr Gly Leu Ser
         275                 280                 285            
 Ser Asn Pro Ile Gln Pro Thr Gly Pro Ser Thr Pro Lys Pro Cys Asp
     290                 295                 300                
 Pro Ser Leu Thr Phe Asp Ala Ile Thr Thr Leu Arg Gly Glu Ile Leu
 305                 310                 315                 320
 Phe Phe Lys Asp Arg Tyr Asp Asn Gln Arg Gln Phe Met Glu Pro Gly
                 325                 330                 335    
 Tyr Pro Lys Ser Ile Ser Gly Ala Phe Pro Gly Ile Glu Ser Lys Val
             340                 345                 350        
 Asp Ala Val Phe Gln Gln Glu Gln Glu Thr Gly Ser Tyr Tyr Ala Asp
         355                 360                 365            
 Gln Ile Ser Ser Met Ser Ser Val Asp Gln Asp Ile Thr His Leu Ile
     370                 375                 380                
 Leu Leu Leu Arg Glu Leu Pro Glu Leu Gln Glu Ala Ile Asn Gly Leu
 385                 390                 395                 400
 Thr Val Asp Met Ala Glu Ala Lys Ser Asn Val Ala Val Ser Thr Phe
                 405                 410                 415    
 Arg Met Leu Lys Gly Ser Ser Ala Ser Ile Phe Val Thr Leu Cys Pro
             420                 425                 430        
 Ala Tyr Thr Phe Leu Asn Ile Lys Ser Leu Phe Pro Ile Thr Val Ser
         435                 440                 445            
 Ile Leu Pro Val Leu Arg Glu Asn Met Phe Gly Ile Phe His Tyr
     450                 455                 460            



      <210> 1463
      <211> 817
      <212> PRT
      <213> Homo sapiens


      <400> 1463
 Met Arg Gln Val Phe Thr Ile Lys Ala Phe Asp Lys Ser Gly Gly Lys
   1               5                  10                  15    
 Gln Pro Cys Ile Ile Leu Leu Asp Glu Asn Glu Val Gln Arg Leu Leu
              20                  25                  30        
 Asp Ile Leu Ser Pro Lys Arg Ser Pro Gln Gln Lys Val Gly Ala Leu
          35                  40                  45            
 Lys Asp Phe Val Leu Ser Ile Arg Glu Gly Gly Val Val Ala Leu Phe
      50                  55                  60                
 Lys Val Cys Arg Gln Asp Ser Phe Arg Cys Leu Tyr Pro Gln Ala Leu
  65                  70                  75                  80
 Arg Thr Leu Ala Ser Ile Cys Cys Val Glu Glu Gly Val His Gln Leu
                  85                  90                  95    
 Glu Lys Ser Cys His Val Glu Val Trp Phe Ile Trp Ala Ala Ala Ser
             100                 105                 110        
 Leu His Pro Lys Leu Gln Asp Ile Cys Pro Ser Phe Pro Val Ser Ser
         115                 120                 125            
 Ser Asp Ile Thr Pro His Ser Leu Pro Leu Cys Trp Val Leu Glu Lys
     130                 135                 140                
 Arg Gln Ala Pro Cys Phe Pro Gly Trp Leu Lys Gly Glu Arg Pro Ser
 145                 150                 155                 160
 Arg Thr Asp Ser Gly Trp Ser Gly Glu Asn Phe Thr Leu Pro Pro Lys
                 165                 170                 175    
 Asp Leu Val Ile Gly Asp Phe Ala Met Thr Met Ala Gly Ser Asn Leu
             180                 185                 190        
 Ser Leu Glu Lys Gly Trp Gly Cys Gln Ala Val Gln Val Pro Lys Cys
         195                 200                 205            
 Ser Ser Gly Phe Ala Gly Ala Gly Ser Ile Arg Arg Gly Ser Val Gly
     210                 215                 220                
 Pro His Val Leu Cys Asn Ser Asp Pro Trp Trp Ile Arg Thr Pro Val
 225                 230                 235                 240
 Ala Ala Pro Ser Gly Cys Leu Gly Leu His Leu Met Gln Val Asp Ser
                 245                 250                 255    
 Val Gln Arg Trp Met Glu Asp Leu Lys Leu Met Thr Glu Cys Glu Cys
             260                 265                 270        
 Met Cys Val Leu Gln Ala Lys Pro Ile Ser Leu Glu Glu Asp Ala Gln
         275                 280                 285            
 Gly Asp Leu Ile Leu Ala Gly Gly Pro Gly Pro Gly Asp Pro Leu Gln
     290                 295                 300                
 Leu Leu Leu Lys Arg Gly Trp Val Ile Ser Thr Glu Leu Arg Arg Ile
 305                 310                 315                 320
 Gly Gln Lys Leu Ala Gln Asp Arg Trp Ala Arg Val His Ser Met Ser
                 325                 330                 335    
 Val Arg Leu Thr Cys His Ala Arg Ser Met Val Ser Glu Tyr Ser Ala
             340                 345                 350        
 Val Ser Arg Asn Ser Leu Lys Glu Met Gly Glu Ile Glu Lys Leu Leu
         355                 360                 365            
 Met Glu Lys Cys Ser Glu Leu Ser Ala Val Thr Glu Arg Cys Leu Gln
     370                 375                 380                
 Val Glu Asn Glu His Val Leu Lys Ser Met Lys Ala Cys Val Ser Glu
 385                 390                 395                 400
 Thr Leu Ser Met Leu Gly Gln His Phe Gly Gln Leu Leu Glu Leu Ala
                 405                 410                 415    
 Leu Thr Arg Glu Val Gln Ala Pro Met Ser Val Gln Gln Val Leu Gly
             420                 425                 430        
 Ile Ile Thr Pro Asp Pro Asn Asn Arg Lys Ala Leu Val Arg Lys Ile
         435                 440                 445            
 Asp Ala Ser Asp Asn Ile Tyr Thr Thr Glu Ser Thr Thr Gly Asn Leu
     450                 455                 460                
 Phe Ser Leu Thr Gln Glu Gly Ala Pro Leu Cys Arg Ile Ile Ala Lys
 465                 470                 475                 480
 Glu Gly Gly Val Val Ala Leu Phe Lys Val Cys Arg Gln Asp Ser Phe
                 485                 490                 495    
 Arg Cys Leu Tyr Pro Gln Ala Leu Arg Thr Leu Ala Ser Ile Cys Cys
             500                 505                 510        
 Val Glu Glu Gly Val His Gln Leu Glu Lys Ala Leu Lys Arg Asn Lys
         515                 520                 525            
 Thr Tyr Pro Gly Trp Ser Gly Glu Asn Phe Thr Leu Pro Pro Lys Asp
     530                 535                 540                
 Leu Val Ile Gly Asp Phe Ala Met Thr Met Ala Gly Cys Gln Val Asp
 545                 550                 555                 560
 Gly Val Leu Cys Leu Ala Asp Ile Leu Thr Asp Asn Ser His Ser Glu
                 565                 570                 575    
 Ala Thr Arg Ala Glu Ala Ala Ala Val Val Ala Gln Val Thr Ser Pro
             580                 585                 590        
 His Leu Pro Val Thr Gln His Leu Ser Ser Phe Leu Glu Ser Met Glu
         595                 600                 605            
 Glu Ile Val Thr Ala Leu Val Lys Leu Cys Gln Glu Ala Ser Ser Gly
     610                 615                 620                
 Glu Val Phe Leu Leu Ala Ser Ala Ala Leu Ala Asn Ile Thr Phe Phe
 625                 630                 635                 640
 Asp Thr Met Ala Cys Glu Met Leu Leu Gln Leu Asn Ala Ile Arg Val
                 645                 650                 655    
 Leu Leu Glu Ala Cys Ser Asp Lys Gln Arg Val Asp Thr Pro Tyr Thr
             660                 665                 670        
 Arg Asp Gln Ile Val Thr Ile Leu Ala Asn Met Ser Val Leu Glu Gln
         675                 680                 685            
 Cys Ala Ser Asp Ile Ile Gln Glu Asn Gly Val Gln Leu Ile Met Gly
     690                 695                 700                
 Met Leu Ser Glu Lys Pro Arg Ser Gly Thr Pro Ala Glu Val Ala Ala
 705                 710                 715                 720
 Cys Glu Arg Val Gln Gln Lys Ala Ala Val Thr Leu Ala Arg Leu Ser
                 725                 730                 735    
 Arg Asp Pro Asp Val Ala Arg Glu Ala Val Arg Leu Ser Cys Met Ser
             740                 745                 750        
 Arg Leu Ile Glu Leu Cys Arg Ser Pro Ser Glu Arg Asn Ser Ser Asp
         755                 760                 765            
 Ala Val Leu Val Ala Cys Leu Ala Ala Leu Arg Arg Leu Ala Gly Val
     770                 775                 780                
 Cys Pro Glu Gly Leu Gln Asp Ser Asp Phe Gln Gln Leu Val Gln Pro
 785                 790                 795                 800
 Arg Leu Val Asp Ser Phe Leu Leu Cys Ser Asn Met Glu Glu Ser Phe
                 805                 810                 815    
 Val
    



      <210> 1464
      <211> 127
      <212> PRT
      <213> Homo sapiens


      <400> 1464
 Met Pro Phe Arg Lys Cys Ser Asn Pro Asp Val Ala Ser Gly Pro Gly
   1               5                  10                  15    
 Lys Ser Leu Lys Tyr Lys Arg Gln Leu Ser Glu Asp Gly Arg Gln Leu
              20                  25                  30        
 Arg Arg Gly Ser Leu Gly Gly Ala Leu Thr Gly Arg Tyr Leu Leu Pro
          35                  40                  45            
 Asn Pro Val Ala Gly Gln Ala Trp Pro Ala Ser Ala Glu Thr Ser Asn
      50                  55                  60                
 Leu Val Arg Met Arg Ser Gln Ala Leu Gly Gln Ser Ala Pro Ser Leu
  65                  70                  75                  80
 Thr Ala Ser Leu Leu Ser Leu Phe Leu Val Phe Lys Gln Ile Asp Ile
                  85                  90                  95    
 Cys Gly Gly Ala Leu Cys Ser Arg Thr Phe Leu Met Leu Met Ile Leu
             100                 105                 110        
 Ser Ser Trp Pro Leu Cys Leu Pro Leu Ala Pro Val Val Glu Leu
         115                 120                 125        



      <210> 1465
      <211> 520
      <212> PRT
      <213> Homo sapiens


      <400> 1465
 Met Asp Leu Glu Glu Met Ala Arg Ser Trp Trp Arg Lys Arg Ser Gln
   1               5                  10                  15    
 Gly Arg Lys Arg Trp Ser Gln Ser Cys Arg Arg Lys Asn Arg Gly Glu
              20                  25                  30        
 Val Ser Gln Arg Val Lys Glu Gly Glu Ser Phe Trp Asp Glu Gly His
          35                  40                  45            
 Ser Phe Asn Asp Val Lys Ser Ser Lys Gln Leu Cys Gly Ser Leu Glu
      50                  55                  60                
 Asn Gln Gln Pro Thr Ile Thr Val Lys Ala Asn Ser Leu Ala Ala Thr
  65                  70                  75                  80
 Gly Gly Gly Thr Val Val Leu Glu Phe Leu Gln Asn Leu Ile Pro Thr
                  85                  90                  95    
 Asp Leu Ser Gly Phe Ala Leu Ser Gly Ser Ser Gln Glu Asp Phe Asn
             100                 105                 110        
 Cys Lys Thr Leu Ile Ala Asp Leu Leu Asp Leu Lys Ile Thr Arg Ser
         115                 120                 125            
 Asp Arg Ile Arg Leu Gly Pro Val Gly Arg His Cys Ser Arg Ser Asn
     130                 135                 140                
 Thr Glu Ser Val Phe Ser Gly Tyr Arg Thr Pro Gly Val Arg Ala Ser
 145                 150                 155                 160
 Ser Asn Leu Pro Trp Asp Pro Ala Lys Glu Ala Ser Gln Thr Ala Gly
                 165                 170                 175    
 Lys Pro Ala Ser Pro Tyr Cys Pro Glu Ala Arg His Leu His Gly Thr
             180                 185                 190        
 Asp Arg Ala Ala Val Thr Asn Ser Asn His Pro Val Leu Asp Phe Ser
         195                 200                 205            
 Arg His Val Glu Ser Gln Phe Ser His Leu Gln Ile Gly Ser Asp Glu
     210                 215                 220                
 Tyr Leu Pro Tyr Lys Val Val Met Arg Ile Lys Cys Asp His Leu Asp
 225                 230                 235                 240
 Thr Pro Val Ser Ala Asp Ser Ile Ser Ser Ala Ser Ser Pro Arg Arg
                 245                 250                 255    
 Glu Thr Leu Glu Asn Arg Asp His Phe Ser Ala Arg Asp Ser Glu Ser
             260                 265                 270        
 Leu Ala Gln Asp Asp Ala Pro Ser Leu Leu Pro Glu Cys Thr Ser Ser
         275                 280                 285            
 Val Val Ile Leu Thr Ala Thr Lys Ser Val Leu Leu Ser Leu Leu Phe
     290                 295                 300                
 Ala Cys Arg Asn Val Lys Asp Cys Ser Ser Trp Arg Tyr Lys Leu Lys
 305                 310                 315                 320
 Pro Ala Pro Val Gln Asn Cys Tyr Lys Trp Ser Leu Gln Arg Val Val
                 325                 330                 335    
 Thr Gln Val Thr Pro Val Thr Pro Trp Gly Pro Cys Gln Lys Arg Lys
             340                 345                 350        
 Cys Ala Ile Met Gly Gln Leu Lys Lys Pro Val Ile Ser Gln Ala Val
         355                 360                 365            
 Phe Val Gly Thr Gly Pro Lys His Leu Val Asn Phe Phe Ser Ala Asn
     370                 375                 380                
 Ser Asp Asn Asn Val Arg Ala Ser His Leu Thr His Gly Val Ala Thr
 385                 390                 395                 400
 Trp Arg Lys His Lys Ile Phe Thr Ser Ser Ser Glu Glu Cys Gln Glu
                 405                 410                 415    
 Phe Ile Leu His Ala Val Glu Lys Leu Met Leu Gln Glu Pro Arg Thr
             420                 425                 430        
 Gln Asn Gln Ala Glu Asp Arg Leu Leu Asp Glu Gly Lys Ala Glu Lys
         435                 440                 445            
 Gly Leu Leu Gln Ile Arg Ile Pro Leu Ala Phe Val Thr Glu Val Ala
     450                 455                 460                
 Met Leu Leu Leu Leu Tyr Ala Met Gly Ser Leu Arg Ala Gln Ser Asp
 465                 470                 475                 480
 Leu Gln Ser Leu Arg Thr Gln Ser Thr Phe Ser Ser Val Ser Pro Ser
                 485                 490                 495    
 Arg Met Gln Gln Gln Gly Thr Ile Leu Glu Ala Glu Ser Ser Pro His
             500                 505                 510        
 Gln Thr Pro Ile Leu Leu Ala Pro
         515                 520



      <210> 1466
      <211> 628
      <212> PRT
      <213> Homo sapiens


      <400> 1466
 Met Ser Leu Gly Gly Ala Ser Glu Arg Ser Val Pro Ala Thr Lys Ile
   1               5                  10                  15    
 Glu Ile Thr Val Ser Cys Arg Asn Leu Leu Asp Leu Asp Thr Phe Ser
              20                  25                  30        
 Lys Ser Asp Pro Met Val Val Leu Tyr Thr Gln Ser Arg Ala Ser Gln
          35                  40                  45            
 Glu Trp Arg Glu Gly Val Ala Arg Glu Phe Pro Cys Pro Ser Ala Arg
      50                  55                  60                
 Pro Thr Leu Thr Leu His Pro Pro Thr Gln Phe Gly Arg Thr Glu Val
  65                  70                  75                  80
 Ile Asp Asn Thr Leu Asn Pro Asp Phe Val Arg Lys Phe Val Leu Asp
                  85                  90                  95    
 Tyr Phe Phe Glu Glu Lys Gln Asn Leu Arg Phe Asp Val Tyr Asn Val
             100                 105                 110        
 Asp Ser Lys Thr Asn Ile Ser Lys Pro Val Ser Lys Arg Phe Leu Glu
         115                 120                 125            
 Gly Pro Gln Pro Thr Leu Leu Val Pro Leu Leu Leu Pro Glu Cys Pro
     130                 135                 140                
 Ala Cys Ala Pro Tyr Ser Leu Phe Leu Phe Leu Leu Gly Cys His Cys
 145                 150                 155                 160
 Trp Asp Leu Gln Lys Asp Phe Leu Gly Gln Ala Phe Leu Ala Leu Gly
                 165                 170                 175    
 Glu Val Ile Gly Gly Gln Gly Ser Arg Val Glu Arg Thr Leu Thr Gly
             180                 185                 190        
 Val Pro Gly Lys Lys Cys Gly Thr Ile Leu Leu Thr Ala Glu Glu Leu
         195                 200                 205            
 Ser Asn Cys Arg Asp Ile Ala Thr Met Gln Leu Cys Ala Asn Lys Leu
     210                 215                 220                
 Asp Lys Lys Asp Phe Phe Gly Lys Ser Asp Pro Phe Leu Val Phe Tyr
 225                 230                 235                 240
 Arg Ser Asn Glu Asp Gly Thr Phe Thr Ile Cys His Lys Thr Glu Val
                 245                 250                 255    
 Val Lys Asn Thr Leu Asn Pro Val Trp Gln Pro Phe Ser Ile Pro Val
             260                 265                 270        
 Arg Ala Leu Cys Asn Gly Asp Tyr Asp Arg Thr Val Lys Ile Asp Val
         275                 280                 285            
 Tyr Asp Trp Asp Arg Asp Gly Ser His Asp Phe Ile Gly Glu Phe Thr
     290                 295                 300                
 Thr Ser Tyr Arg Glu Leu Ser Lys Ala Gln Asn Gln Phe Thr Val Tyr
 305                 310                 315                 320
 Glu Val Leu Asn Pro Arg Lys Lys Cys Lys Lys Lys Lys Tyr Val Asn
                 325                 330                 335    
 Ser Gly Thr Val Thr Leu Leu Ser Phe Ser Val Asp Ser Glu Phe Thr
             340                 345                 350        
 Phe Val Asp Tyr Ile Lys Gly Gly Thr Gln Leu Asn Phe Thr Val Ala
         355                 360                 365            
 Ile Asp Phe Thr Ala Ser Asn Gly Glu Thr Arg Met Ser Glu Lys Val
     370                 375                 380                
 Gly Gly Asn Pro Leu Gln Pro Thr Ser Leu His Tyr Met Ser Pro Tyr
 385                 390                 395                 400
 Gln Leu Ser Ala Tyr Ala Met Ala Leu Lys Ala Val Gly Glu Ile Ile
                 405                 410                 415    
 Gln Asp Tyr Asp Ser Asp Lys Leu Phe Pro Ala Tyr Gly Phe Gly Ala
             420                 425                 430        
 Lys Leu Pro Pro Glu Gly Arg Ile Ser His Gln Phe Pro Leu Asn Asn
         435                 440                 445            
 Asn Asp Glu Asp Pro Asn Cys Ala Gly Ile Glu Gly Val Leu Glu Ser
     450                 455                 460                
 Tyr Phe Gln Ser Leu Arg Thr Val Gln Leu Tyr Gly Pro Thr Tyr Phe
 465                 470                 475                 480
 Ala Pro Val Ile Asn Gln Val Ala Arg Ala Ala Ala Lys Ile Ser Asp
                 485                 490                 495    
 Gly Ser Gln Tyr Tyr Val Leu Leu Ile Ile Thr Asp Gly Val Ile Ser
             500                 505                 510        
 Asp Met Thr Gln Thr Lys Glu Ala Ile Val Ser Ala Ser Ser Leu Pro
         515                 520                 525            
 Met Ser Ile Ile Ile Val Gly Val Gly Pro Ala Met Phe Glu Ala Met
     530                 535                 540                
 Glu Glu Leu Asp Gly Asp Asp Val Arg Val Ser Ser Arg Gly Arg Tyr
 545                 550                 555                 560
 Ala Glu Arg Asp Ile Val Gln Phe Val Pro Phe Arg Asp Tyr Val Asp
                 565                 570                 575    
 Arg Ser Gly Asn Gln Val Leu Ser Met Ala Arg Leu Ala Lys Asp Val
             580                 585                 590        
 Leu Ala Glu Ile Pro Glu Gln Leu Leu Ser Tyr Met Arg Thr Arg Asp
         595                 600                 605            
 Ile Gln Pro Arg Pro Pro Pro Pro Ala Asn Pro Ser Pro Ile Pro Ala
     610                 615                 620                
 Pro Glu Gln Pro
 625            



      <210> 1467
      <211> 205
      <212> PRT
      <213> Homo sapiens


      <400> 1467
 Met Phe Arg Leu Asn Ser Leu Ser Ala Leu Ala Glu Leu Ala Val Gly
   1               5                  10                  15    
 Ser Arg Trp Tyr His Gly Gly Ser Gln Pro Ile Gln Ile Arg Arg Arg
              20                  25                  30        
 Leu Met Met Val Ala Phe Leu Gly Ala Ser Ala Val Thr Ala Ser Thr
          35                  40                  45            
 Gly Leu Leu Trp Lys Arg Ala His Ala Glu Ser Pro Pro Cys Val Asp
      50                  55                  60                
 Asn Leu Lys Ser Asp Ile Gly Asp Lys Gly Lys Asn Lys Asp Glu Gly
  65                  70                  75                  80
 Asp Val Cys Asn His Glu Lys Lys Thr Ala Asp Leu Ala Pro His Pro
                  85                  90                  95    
 Glu Glu Lys Lys Lys Lys Arg Ser Gly Phe Arg Asp Arg Lys Val Met
             100                 105                 110        
 Glu Tyr Glu Asn Arg Ile Arg Ala Tyr Ser Thr Pro Asp Lys Ile Phe
         115                 120                 125            
 Arg Tyr Phe Ala Thr Leu Lys Val Ile Ser Glu Pro Gly Glu Ala Glu
     130                 135                 140                
 Val Phe Met Thr Pro Glu Asp Phe Val Arg Ser Ile Thr Pro Asn Glu
 145                 150                 155                 160
 Lys Gln Pro Glu His Asp Leu Pro Val Thr Glu Asn Leu Gly Leu Asp
                 165                 170                 175    
 Gln Tyr Ile Ile Lys Arg Phe Asp Gly Lys Gly Asn Ser Cys Phe Lys
             180                 185                 190        
 Asn Thr Val Thr Asp Ala Lys Arg Ile Lys Val Phe Pro
         195                 200                 205



      <210> 1468
      <211> 226
      <212> PRT
      <213> Homo sapiens


      <400> 1468
 Met Ala Met Trp Leu Tyr Pro Val Ala Val Gly Ser Leu Glu Gly Gly
   1               5                  10                  15    
 Val Glu Asn Val Gly Gly Pro Ile Ser Ser Lys Val Gly Cys Arg Leu
              20                  25                  30        
 Ala Arg Tyr Ser Val Arg Val Ser Pro Gln Met Ala Asn Arg Ile Val
          35                  40                  45            
 Asp Ser Ala Arg Ser Ile Leu Asn Lys Phe Ile Pro Asp Ile Tyr Ile
      50                  55                  60                
 Tyr Thr Asp His Met Lys Gly Val Asn Ser Gly Lys Ser Pro Gly Phe
  65                  70                  75                  80
 Gly Leu Ser Leu Val Ala Glu Thr Thr Ser Gly Thr Phe Leu Ser Ala
                  85                  90                  95    
 Glu Leu Ala Ser Asn Pro Gln Gly Gln Gly Ala Ala Val Leu Pro Glu
             100                 105                 110        
 Asp Leu Gly Arg Asn Cys Ala Arg Leu Leu Leu Glu Glu Ile Tyr Arg
         115                 120                 125            
 Val Cys Trp Trp Asp Thr Ala Glu Thr Asn Leu Pro Ser Gln Leu Pro
     130                 135                 140                
 Gln Ser Phe Ser Val Asp Pro Phe Ile Ala Thr Gly Thr Tyr Ala Cys
 145                 150                 155                 160
 Thr His Phe Tyr Cys Phe Leu Lys Ile Val Ser Leu Thr Leu Leu Pro
                 165                 170                 175    
 Arg Ile Glu Phe Leu Arg His Leu Lys Ser Phe Phe Gln Ile Met Phe
             180                 185                 190        
 Lys Ile Glu Thr Lys Pro Cys Gly Glu Glu Leu Lys Gly Gly Asp Lys
         195                 200                 205            
 Val Leu Met Thr Cys Val Gly Ile Gly Phe Ser Asn Leu Ser Lys Thr
     210                 215                 220                
 Leu Lys
 225    



      <210> 1469
      <211> 125
      <212> PRT
      <213> Homo sapiens


      <400> 1469
 Met Asn Gly His Ile Ser Trp Gln Val Pro Val Trp Glu Glu Met Leu
   1               5                  10                  15    
 Ser Asp Tyr Arg Thr Val Leu Phe Thr Leu Thr Ser Val Val Val Leu
              20                  25                  30        
 Val Ile Thr Thr Asp Trp Ile Ser Trp Asp Lys Leu Asn Arg Gly Phe
          35                  40                  45            
 Leu Pro Ser Asp Glu Val Ser Arg Ala Phe Leu Ala Ser Phe Ile Leu
      50                  55                  60                
 Val Phe Asp Leu Leu Ile Val Met Gln Gln Trp Pro Arg Gly Thr Glu
  65                  70                  75                  80
 Ser Met Cys Leu Gly Glu Gly Gly Glu His Ser Asp Tyr Gly Thr Leu
                  85                  90                  95    
 His Trp Asn Leu Val Leu Pro Val Ile Ala Glu Cys Asn Thr Gly Gln
             100                 105                 110        
 Asn Ser Ala Gly Thr His Arg Glu His Leu Asp Gln Pro
         115                 120                 125



      <210> 1470
      <211> 538
      <212> PRT
      <213> Homo sapiens


      <400> 1470
 Met Pro Ser Asn Lys Gln Gln Pro Pro Leu Pro Leu Ser Val Leu Gly
   1               5                  10                  15    
 Leu Asn Ile Leu Glu Ile Leu Gly Leu Ala Ala Thr Ser Cys Ala Val
              20                  25                  30        
 Val Pro Arg Ser Val Thr Pro Ser Val Thr Ser Gly Ser Ala Asp Gly
          35                  40                  45            
 Asp Gly Gln Ser Leu Ala Val Gly Thr Gly Thr Leu Ala Thr Pro Thr
      50                  55                  60                
 Gly Gly Gln Asp His Thr Val Ala Gly Phe Glu Pro Pro Ala Leu Pro
  65                  70                  75                  80
 Ala Pro Glu Thr Ser Arg Lys Lys Asn Ala Lys Ala Val Leu Ser Pro
                  85                  90                  95    
 Gln Gly Thr Thr Glu Ser Pro Gly Leu Arg Arg Lys Asp Gly Thr Gln
             100                 105                 110        
 Arg Ala Leu Val Ser Gly Ala Tyr Leu Pro Ile Leu Tyr Pro Ala Pro
         115                 120                 125            
 Glu Glu Ser Gln Pro Pro Ala Pro Ala Phe Pro Arg Thr Pro Gly Asp
     130                 135                 140                
 Ser Asp His Arg Gln Val Trp Gly His Ser Pro Gly Leu Val Ser Gly
 145                 150                 155                 160
 Val Cys Arg Leu Ser Ala Pro Cys Ser Ser Ser Gln Val Val Gly Gln
                 165                 170                 175    
 Gly Ser Ser Pro Arg Pro Pro Glu Pro Asp Arg Arg Arg His His His
             180                 185                 190        
 Gln Arg Pro Gly Gly Pro Arg Ala Pro Arg Ala Arg Leu Arg Ser Glu
         195                 200                 205            
 Pro Thr Lys Lys Glu Ala Glu Ala Gly Pro Arg Ser Gln Arg Glu Trp
     210                 215                 220                
 Thr Gly Leu Ser Thr Leu Pro His Lys Phe Thr Pro Asn Thr Thr Gly
 225                 230                 235                 240
 His Thr Val Glu Leu Gly Pro Arg Ser Gly Gly Ala Leu Val Val Pro
                 245                 250                 255    
 Ser Gly Asn His Thr Asp Asp Asp Asp Glu Asp Asp Asp Gly Lys Gly
             260                 265                 270        
 Gly Ser Asn Asn Asp Asp Ser Asp Lys Asp Asp Asn Ser Asn Thr Ser
         275                 280                 285            
 His Gln Ala Gln Cys Ser Glu Ser Asn Phe Asn Met Arg Phe Gly Arg
     290                 295                 300                
 Asp Lys Tyr Pro Asn Tyr Ser Asn Lys Asn Asp Glu Asn Asn Asp Asp
 305                 310                 315                 320
 Asp Glu Asp Asp Gly Asp Asn Ser Val Pro Gly Pro Val Leu Glu Ala
                 325                 330                 335    
 Gly Gly Ser Met Pro Ala Cys Arg Gly Ala Asp Met Gly Leu Lys Met
             340                 345                 350        
 Ser Cys Leu Lys Gly Val Phe Val Tyr Ser Ala Asp Leu His Thr Gln
         355                 360                 365            
 Ala Ala Asn Arg Ser Gln Arg Thr Val Ala Val Pro Trp Cys Trp Phe
     370                 375                 380                
 Pro Ser Ser Ala Gly Gln Ser Pro Glu Glu Ser Val Ser Arg Ala Thr
 385                 390                 395                 400
 Pro His Lys His Val Leu Ser Thr Cys Cys Met Pro Gly Ser Thr Leu
                 405                 410                 415    
 Ser Pro Arg Asp Ala Ala Val Ser Ser Thr Glu Leu Leu Ser Met Gly
             420                 425                 430        
 Glu Arg Arg Lys Cys Gly Met Val Cys Val Asn Lys His Thr Pro Ser
         435                 440                 445            
 Arg Leu Asp Phe Val Val Ser Ala Val Lys Gly Ile Glu Gln Gly Gly
     450                 455                 460                
 Ala Val Glu Gly Met Arg Gln Gly Phe Gln Met Cys Val Ser Ser Ser
 465                 470                 475                 480
 Ser Ser Ser His Asp Glu Ala Pro Val Leu Asn Asp Lys His Leu Asp
                 485                 490                 495    
 Val Pro Asp Ile Ile Ile Thr Pro Pro Thr Pro Thr Gly Met Met Leu
             500                 505                 510        
 Pro Arg Asp Leu Gly Ser Thr Val Trp Leu Asp Glu Thr Gly Ser Cys
         515                 520                 525            
 Pro Asp Asp Gly Glu Ile Asp Pro Glu Ala
     530                 535            



      <210> 1471
      <211> 158
      <212> PRT
      <213> Homo sapiens


      <400> 1471
 Met Gly Phe His Arg Val Ala Gln Ala Gly Leu Lys Leu Leu Thr Ser
   1               5                  10                  15    
 Gly Met Gln Tyr Cys Phe Trp Phe Thr Ile Leu Val Lys Arg Glu Leu
              20                  25                  30        
 Ser Met Asp Phe Tyr Leu Val Pro Pro Thr Ile Met Ala Leu Thr Tyr
          35                  40                  45            
 Gly Ser Glu Lys Glu Leu Gly Asp Ser Glu Ser Asp Lys Tyr Ile Asn
      50                  55                  60                
 Ser Lys Tyr Thr Ser Lys Arg Ser Ser Ala Ala Glu His Phe His Ile
  65                  70                  75                  80
 Arg Cys His Phe Gln Trp Asp Phe Leu Pro Arg Cys Gln Val Pro Gly
                  85                  90                  95    
 Asp Pro Ala Met Val Arg Ala Gly Ala Val Gly Ala His Leu Pro Ala
             100                 105                 110        
 Ser Gly Leu Asp Ile Phe Gly Asp Leu Lys Lys Met Asn Lys Arg Gln
         115                 120                 125            
 Val Thr Glu Glu Gly Gly Glu Arg Ala Val Ala Gly Thr Ala Cys Ala
     130                 135                 140                
 Ser Gly Glu Ser Gly Leu Pro Ser Gln Gly Ser Gly Ser Gln
 145                 150                 155            



      <210> 1472
      <211> 108
      <212> PRT
      <213> Homo sapiens


      <400> 1472
 Met Val Arg Ser Arg Trp Trp Leu Ser Leu Arg Ser Cys Trp Val His
   1               5                  10                  15    
 Leu Gln Lys Gly Cys His Phe Thr Leu Gly Arg Leu His Asn Gly Gln
              20                  25                  30        
 Ala Glu Val Leu Leu Thr Ser Gln Met Gly Arg Leu Gly Arg Gly Ala
          35                  40                  45            
 Pro His Phe Pro Asp Gly Ala Thr Arg Gln Glu Val Leu Leu Ile Ser
      50                  55                  60                
 Gln Met Gly Arg Leu Gly Arg Gly Thr Pro Tyr Arg Ser Cys Gly Asn
  65                  70                  75                  80
 Gly Ala Ala Thr Ser Arg Ser Leu Asn Gly Arg Ala Thr Gly Ser Phe
                  85                  90                  95    
 His Pro Glu Pro Arg Asn Thr Thr Gly Thr Gln Leu
             100                 105            



      <210> 1473
      <211> 131
      <212> PRT
      <213> Homo sapiens


      <400> 1473
 Met Arg Pro Arg Ser Gly Gly Arg Pro Gly Ala Thr Gly Arg Arg Arg
   1               5                  10                  15    
 Arg Arg Leu Arg Arg Arg Pro Arg Gly Leu Arg Cys Ser Arg Leu Pro
              20                  25                  30        
 Pro Pro Pro Pro Leu Pro Leu Leu Leu Gly Leu Leu Leu Ala Ala Ala
          35                  40                  45            
 Gly Pro Gly Ala Ala Arg Ala Lys Glu Thr Ala Phe Val Glu Val Val
      50                  55                  60                
 Leu Phe Glu Ser Ser Pro Ser Gly Asp Tyr Thr Thr Tyr Thr Thr Gly
  65                  70                  75                  80
 Leu Thr Gly Arg Phe Ser Arg Ala Gly Ala Thr Leu Ser Ala Glu Gly
                  85                  90                  95    
 Glu Ile Val Gln Ala Trp Ser Pro Ser Val Thr Pro Gly Cys Ser Leu
             100                 105                 110        
 Ala Glu Cys Asp Arg Gly His Gln Met Gln Gly Met Leu Tyr Asp Gln
         115                 120                 125            
 Met Tyr Asn
     130    



      <210> 1474
      <211> 301
      <212> PRT
      <213> Homo sapiens


      <400> 1474
 Met Ser Ile Leu Ser Arg Arg Tyr Ala Leu Cys Gln Leu Ala Ala Cys
   1               5                  10                  15    
 Val Phe Pro Phe His Ile Trp Thr Cys Ile Cys Ser His Phe Thr Ser
              20                  25                  30        
 Pro Val Asn Ala Arg Leu Thr Glu Tyr Val Lys Leu Pro Ser Thr Gln
          35                  40                  45            
 Ala Gly Asn Arg Ala Lys Leu Leu Ala Ser Lys Ser Pro Trp Glu Ser
      50                  55                  60                
 Gln His Ser Pro Phe Phe Ala Glu Gln Leu Thr Ala Phe Gln Val Trp
  65                  70                  75                  80
 Leu Thr Met Gly Val Glu Asn Arg Asn Pro Pro Glu Gln Leu Pro Ile
                  85                  90                  95    
 Val Leu Gln Ala Leu Ser Val Gly Ile Phe Pro Tyr Val Leu Lys Leu
             100                 105                 110        
 Leu Gln Ser Ser Ala Arg Glu Leu Arg Pro Leu Leu Val Phe Ile Trp
         115                 120                 125            
 Ala Lys Ile Leu Ala Val Asp Ser Gly Asn Gly Arg Ser Ser Lys Val
     130                 135                 140                
 Thr Glu Gln Val Gln Glu Ser Ala Lys Asn Thr Leu Glu Arg Pro Trp
 145                 150                 155                 160
 Leu Gly Ala Gly Glu Asp His Pro Phe Leu Phe Cys Val Ala Ala Ala
                 165                 170                 175    
 Ala Asp Ser Ser Pro Ala Gln Ala Ile Arg Ser Pro Thr Val Leu Pro
             180                 185                 190        
 Thr Asp Pro Trp Ala Pro Ala Gln Pro Phe Cys Ser Leu His Pro Ala
         195                 200                 205            
 Leu Thr Ile Ala Ser Pro His Pro Lys Ser Ser Arg Thr Thr Leu Val
     210                 215                 220                
 Ser Gln Leu Lys Ser Gly Gly Ser Gly Glu Ala Ala Ala Glu Ala Asp
 225                 230                 235                 240
 Asp Phe Leu Gln Met Glu Lys Val Arg Val Thr Ala Gly Phe Phe Leu
                 245                 250                 255    
 Gln Ile Ser Tyr Arg Trp Lys Ser Val Glu Thr Glu Arg His Asn Glu
             260                 265                 270        
 Lys Ala Glu Ala Thr Arg Leu Lys Ser Lys Lys Lys Pro Tyr His Gly
         275                 280                 285            
 Tyr Lys Gln Cys Thr Phe Gly Ile Lys Thr Arg Val Asp
     290                 295                 300    



      <210> 1475
      <211> 342
      <212> PRT
      <213> Homo sapiens


      <400> 1475
 Met Ser Gly Gly Met Trp Ile Ala Ile Leu Ala Trp Thr Lys Val Val
   1               5                  10                  15    
 Lys Asp Arg Asn Phe Ser Phe Cys Ile Leu Phe Glu Thr Arg Ser Ile
              20                  25                  30        
 Ser Tyr Ile Asp Gly Phe Tyr Glu Asn Gly Gln Lys Ile Ile Glu Asn
          35                  40                  45            
 Trp Lys Glu Thr Asn Asn Ser Ile Gln Lys Asn Met Leu Ile Phe Gly
      50                  55                  60                
 Asn Gly Lys Leu Phe Lys Ala Lys Tyr Val Arg His Asp Phe Val Leu
  65                  70                  75                  80
 Phe Ala Phe His Tyr Asp Cys Lys Phe Pro Glu Ala Ser Pro Ala Met
                  85                  90                  95    
 Leu Pro Asn Pro Gly Gly Ile Cys Cys Leu Ser His Ile Pro Leu Gln
             100                 105                 110        
 Thr Asp Pro Pro Glu Gly Leu Gly Arg Lys Pro Ser Leu Ala Trp Ala
         115                 120                 125            
 Arg Cys Ser Val Tyr Val Val Asn Glu Glu Leu Ile Asn Trp Ile Arg
     130                 135                 140                
 Gly Gly Pro Ser Lys Leu Ser Gly Leu Pro Glu Asp Ser Val Gly Leu
 145                 150                 155                 160
 Gly Tyr Val Glu Trp Asp Leu Thr Met Met Ser Val Leu Leu Gly Ile
                 165                 170                 175    
 Leu Ser Pro Val Ser Gln Arg Gly His Gln Phe Thr Asp Trp Ile Lys
             180                 185                 190        
 Lys Met Trp His Ile Tyr Thr Met Glu Tyr Tyr Ala Ala Ile Lys Lys
         195                 200                 205            
 Asp Glu Phe Met Ser Phe Val Gly Thr Trp Met Lys Leu Glu Thr Ile
     210                 215                 220                
 Ile Leu Ser Lys Leu Ser Gln Gly Gln Lys Thr Lys His Arg Met Phe
 225                 230                 235                 240
 Ser Leu Ile Asp Trp Ile Lys Lys Met Trp His Ile Tyr Thr Met Glu
                 245                 250                 255    
 Tyr Tyr Ala Ala Ile Lys Lys Asp Glu Phe Met Pro Phe Val Gly Thr
             260                 265                 270        
 Trp Met Lys Leu Glu Thr Ile Ile Leu Ser Lys Leu Ser Gln Gly Gln
         275                 280                 285            
 Lys Thr Lys His Arg Met Phe Ser Leu Ile Glu Glu Val Lys Glu Thr
     290                 295                 300                
 Val Tyr Thr Ser Ala Pro Phe Asp Lys His Leu Leu Thr Thr Ala Lys
 305                 310                 315                 320
 Met Pro Gly Thr Trp Thr Phe Arg Met Pro Ala Phe Lys Glu Thr Pro
                 325                 330                 335    
 Asp Ser Val Glu Trp Ile
             340        



      <210> 1476
      <211> 519
      <212> PRT
      <213> Homo sapiens


      <400> 1476
 Met Ile Ile Ser His Phe Pro Lys Cys Val Ala Val Phe Ala Leu Leu
   1               5                  10                  15    
 Ala Leu Ser Val Gly Ala Leu Asp Thr Phe Ile Ala Ala Val Tyr Glu
              20                  25                  30        
 His Ala Val Ile Leu Pro Asn Arg Thr Glu Thr Pro Val Ser Lys Glu
          35                  40                  45            
 Glu Ala Leu Leu Leu Met Asn Lys Asn Ile Asp Val Leu Glu Lys Ala
      50                  55                  60                
 Val Lys Leu Ala Ala Lys Gln Val Leu Pro Phe Tyr Thr Cys Lys Gly
  65                  70                  75                  80
 Asp Leu Gln Phe Gly Gln Arg Val Phe Gly Ile His Asp Lys Leu Phe
                  85                  90                  95    
 Cys Pro Thr Cys Phe Glu Gln Gly Ala His Ile Ile Val Thr Pro Glu
             100                 105                 110        
 Asp Gly Ile Tyr Gly Trp Ile Phe Thr Arg Glu Ser Ile Tyr Pro Tyr
         115                 120                 125            
 Leu Glu Asp Ile Pro Asp Pro Gly Val Asn Trp Ile Pro Cys Arg Asp
     130                 135                 140                
 Pro Trp Arg Phe Gly Asn Thr Pro Val Gln Gln Arg Leu Ser Cys Leu
 145                 150                 155                 160
 Ala Lys Asp Asn Ser Ile Tyr Val Val Ala Asn Ile Gly Asp Lys Lys
                 165                 170                 175    
 Pro Cys Asn Ala Ser Asp Ser Gln Cys Pro Pro Asp Gly Arg Tyr Gln
             180                 185                 190        
 Tyr Asn Thr Asp Val Val Phe Asp Ser Gln Gly Lys Leu Leu Ala Arg
         195                 200                 205            
 Tyr His Lys Tyr Asn Leu Phe Ala Pro Glu Ile Gln Phe Asp Phe Pro
     210                 215                 220                
 Lys Asp Ser Glu Leu Val Thr Phe Asp Thr Pro Phe Gly Lys Phe Gly
 225                 230                 235                 240
 Ile Phe Thr Cys Phe Asp Ile Phe Ser His Asp Pro Ala Val Val Val
                 245                 250                 255    
 Val Asp Glu Phe Gln Leu Thr Ala Phe Ser Thr Pro Gln His Ala Trp
             260                 265                 270        
 Ala Lys Ala Met Gly Val Asn Leu Leu Ala Ala Asn Thr His Asn Thr
         275                 280                 285            
 Ser Met His Met Thr Gly Ser Gly Ile Tyr Ala Pro Glu Ala Val Lys
     290                 295                 300                
 Val Tyr His Tyr Asp Met Glu Thr Glu Ser Gly Gln Leu Leu Leu Ser
 305                 310                 315                 320
 Glu Leu Lys Ser Arg Pro Arg Arg Glu Pro Thr Tyr Pro Ala Ala Val
                 325                 330                 335    
 Asp Trp His Ala Tyr Ala Ser Ser Val Lys Pro Phe Ser Ser Glu Gln
             340                 345                 350        
 Ser Asp Phe Leu Gly Met Ile Tyr Phe Asp Glu Phe Thr Phe Thr Lys
         355                 360                 365            
 Leu Lys Arg Asn Thr Gly Asn Tyr Thr Ala Cys Gln Lys Asp Leu Cys
     370                 375                 380                
 Cys His Leu Thr Tyr Lys Met Ser Glu Lys Arg Thr Asp Glu Ile Tyr
 385                 390                 395                 400
 Ala Leu Gly Ala Phe Asp Gly Leu His Thr Val Glu Gly Gln Tyr Tyr
                 405                 410                 415    
 Leu Gln Ile Cys Ala Leu Leu Lys Cys Gln Thr Thr Asp Leu Glu Thr
             420                 425                 430        
 Cys Gly Glu Pro Val Gly Ser Ala Phe Thr Lys Phe Glu Asp Phe Ser
         435                 440                 445            
 Leu Ser Gly Thr Phe Gly Thr Arg Tyr Val Phe Pro Gln Ile Ile Leu
     450                 455                 460                
 Ser Gly Ser Gln Leu Ala Pro Glu Arg His Tyr Glu Ala Phe Arg Pro
 465                 470                 475                 480
 Gly Leu Glu Leu Thr Pro Ser Thr Leu Gln Leu Ser Gly Leu Arg Met
                 485                 490                 495    
 Thr Pro Leu Ala Phe Leu His Leu Gln Leu Ala Asn Gly Arg Pro Asp
             500                 505                 510        
 Cys Gly Ile Ser Gln Pro Ser
         515                



      <210> 1477
      <211> 458
      <212> PRT
      <213> Homo sapiens


      <400> 1477
 Met Val Asp Lys Leu Phe Asp Val Leu Leu Asp Ser Val Cys Gln Tyr
   1               5                  10                  15    
 Phe Ile Glu Asp Phe Cys Ile Asn Val His Gln Gly Tyr Trp Ser Lys
              20                  25                  30        
 Ile Leu Phe Phe Gly Cys Val Ser Ala Gln Leu Cys Lys Leu Lys Leu
          35                  40                  45            
 Lys Ser Ile His Trp Cys Phe Leu Leu Leu Lys Tyr Lys Leu Leu Leu
      50                  55                  60                
 Val Phe Ile His Leu Arg Tyr Asn Ala Gly Val Ile Phe Phe Tyr Thr
  65                  70                  75                  80
 Lys Val Met Phe Asn Gln Ile Lys Cys Leu Leu Thr Tyr Leu Cys Ala
                  85                  90                  95    
 Ile Tyr Leu Val Trp Ala Tyr Asn Gly Phe Ser Thr Lys Glu Glu Arg
             100                 105                 110        
 Lys Glu Asp Asn Thr Phe Phe Lys Glu Glu Asp Leu Leu Lys Glu Ser
         115                 120                 125            
 Glu Leu Thr Thr Pro Ser Arg Pro Gln Gly Lys Gly Pro Ala Ala Thr
     130                 135                 140                
 Pro Pro Arg Pro Leu Ser Pro Trp Gly Lys His Glu Lys His Pro Ala
 145                 150                 155                 160
 Pro Pro Gly Ser Arg Asp Leu Arg Lys Gln Ile Lys Arg Gln Lys Ile
                 165                 170                 175    
 Phe Glu Ser Thr Cys Asn Leu Cys Pro Glu Pro Leu Gln Asp Val Gln
             180                 185                 190        
 Pro Phe Lys Ile Lys Pro Thr Tyr Ser Phe Arg Val Leu Ile Tyr Asp
         195                 200                 205            
 Val Ala Cys Asn Leu Cys Leu Leu Thr Phe Lys Asn Ser Tyr Leu Pro
     210                 215                 220                
 Lys Ala Leu Thr Gln Leu Val Pro Ala Ser Phe Val Cys Leu Ala Cys
 225                 230                 235                 240
 Ala Phe Gly Ala Glu Arg Leu Gly Asp Ser Ala Leu Arg Ser Ser Asp
                 245                 250                 255    
 Leu Thr His His Leu Leu Val Asn Thr Met Leu Ser Cys Asn Ile Cys
             260                 265                 270        
 Gly Glu Thr Val Thr Ser Glu Pro Asp Met Lys Ala His Leu Ile Val
         275                 280                 285            
 His Met Glu Ser Glu Ile Ile Cys Pro Phe Cys Lys Leu Ser Gly Val
     290                 295                 300                
 Asn Tyr Asp Glu Met Cys Phe His Ile Glu Thr Ala His Phe Glu Gln
 305                 310                 315                 320
 Asn Thr Leu Glu Arg Asn Phe Glu Arg Ile Asn Thr Val Gln Tyr Gly
                 325                 330                 335    
 Thr Ser Asp Asn Lys Lys Asp Asn Thr Leu Gln Cys Gly Met Glu Val
             340                 345                 350        
 Asn Ser Ser Ile Leu Ser Gly Cys Ala Ser Asn His Pro Lys Asn Ser
         355                 360                 365            
 Ala Gln Asn Leu Thr Lys Asp Ser Thr Leu Lys His Glu Gly Phe Tyr
     370                 375                 380                
 Ser Glu Asn Leu Thr Glu Ser Arg Lys Phe Leu Lys Ser Arg Glu Lys
 385                 390                 395                 400
 Gln Ser Ser Leu Thr Glu Ile Lys Gly Ser Val Tyr Glu Thr Thr Tyr
                 405                 410                 415    
 Ser Pro Pro Glu Cys Pro Phe Cys Gly Lys Ile Glu Glu His Ser Glu
             420                 425                 430        
 Asp Met Glu Thr His Val Lys Thr Lys His Ala Asn Leu Leu Asp Ile
         435                 440                 445            
 Pro Leu Glu Gly Lys Val Phe Ile Ser Leu
     450                 455            



      <210> 1478
      <211> 194
      <212> PRT
      <213> Homo sapiens


      <400> 1478
 Met Leu Thr Leu Ile Leu Leu Asp Leu Gln Phe Met Ala Gln Leu Ala
   1               5                  10                  15    
 Gly Tyr Gln Met Ser Phe Asn Ser Thr Lys Ser Lys Gln Thr Lys Asn
              20                  25                  30        
 Asn Phe Ala Val Gly Tyr Arg Thr Gly Asp Phe Gln Leu His Thr Asn
          35                  40                  45            
 Val Asn Asp Gly Ala Glu Phe Gly Gly Ser Val Tyr Gln Lys Val Cys
      50                  55                  60                
 Glu Asp Leu Asp Ala Leu Val Asn Leu Ala Trp Thr Ser Gly Thr Ser
  65                  70                  75                  80
 Cys Thr Arg Phe Gly Leu Ala Ala Lys Phe Gln Leu Lys Pro Ile Ala
                  85                  90                  95    
 Ser Ile Ser Thr Lys Val Asn Asn Trp Leu Thr Gly Val Ser Tyr Thr
             100                 105                 110        
 Pro Pro Leu Arg Pro Gly Val Lys Leu Thr Leu Ser Ala Leu Lys Lys
         115                 120                 125            
 Ile Ala Ala Ser Gly Phe Arg Thr Thr Leu Ile Met Ser Pro Gln Arg
     130                 135                 140                
 Ser Gly Arg Ser Gly Ser Glu Val Leu Gly Asn Phe Val His Thr Glu
 145                 150                 155                 160
 Leu Lys Ala Ser Gly Glu Asp Glu Ala Pro Gly Gln Glu His Glu Asp
                 165                 170                 175    
 Ser Arg Leu Asp Ser Lys Ala Val Pro Gln Val Thr Gln Phe Tyr Arg
             180                 185                 190        
 Asn Ser
        



      <210> 1479
      <211> 212
      <212> PRT
      <213> Homo sapiens


      <400> 1479
 Met Arg Cys Ile Gln Cys Val Leu Ser Lys Gln Leu Leu Val Thr Phe
   1               5                  10                  15    
 Ile Ser Leu Thr Ile Pro Glu Arg Cys Tyr Leu Asn Thr Ile Thr Pro
              20                  25                  30        
 Asp Ala Leu Lys Ser Lys Leu His Ile Pro Thr Thr Leu Arg Gln Lys
          35                  40                  45            
 Ala Leu Pro Ser Ala Pro Ser Gly Leu Met Ser Phe Ala Lys Gln Gly
      50                  55                  60                
 Gly Val Leu Val Pro Asp Gly Lys Ile Ala Cys Phe Ile Tyr Leu Ala
  65                  70                  75                  80
 Thr Phe Gly Ile Leu Arg Ala Leu Leu Val Gln Lys Asn Leu Met Pro
                  85                  90                  95    
 Ala Gly Thr Thr Leu Glu Asp Pro Ile Lys Lys Leu Ile Gln His Asp
             100                 105                 110        
 Gln Phe His Val Cys Trp Gly Gly Leu Thr Ile Met Val Gly Gly Lys
         115                 120                 125            
 Glu Glu Gln Val Met Ser Tyr Met Asp Gly Ser Arg Gln Arg Glu Arg
     130                 135                 140                
 Ala Cys Ala Gly Lys Leu Pro Phe Leu Lys Pro Ser Asp Leu Met Arg
 145                 150                 155                 160
 Leu Ile His Tyr His Gly Asn Ser Thr Gly Met Thr Cys Pro Met Ile
                 165                 170                 175    
 Gln Leu Pro Leu Thr Gly Ser Leu Ser Gln His Met Gly Ile Gln Asp
             180                 185                 190        
 Glu Ile Trp Val Gly Thr Gln Ala Asn His Ile Lys Ser Phe Thr Thr
         195                 200                 205            
 Ser Gln Ala Glu
     210        



      <210> 1480
      <211> 120
      <212> PRT
      <213> Homo sapiens


      <400> 1480
 Met Ala Phe Leu Phe Pro Ile Gln Val Thr Ala Val Trp Val Gly Ile
   1               5                  10                  15    
 Gln Arg Phe Gln Ala Ser Glu Glu Glu Ser Glu Asp Glu Glu Phe Leu
              20                  25                  30        
 Ala Thr Leu Thr Gly Gly Glu Arg Ser Gly Lys Ala Arg Lys Gln Trp
          35                  40                  45            
 Thr Gln Pro Trp Cys Val Met Phe Pro Cys Leu Cys Pro Cys Val Leu
      50                  55                  60                
 Val Val Gln Leu Pro Val Thr Thr Thr Glu Arg Pro Phe Ile Gln Lys
  65                  70                  75                  80
 Leu Phe Arg Pro Val Ala Ala Asp Gly Gln Leu His Thr Leu Gly Asp
                  85                  90                  95    
 Leu Leu Lys Glu Val Cys Pro Ser Ala Ile Asp Pro Glu Gly Phe Asp
             100                 105                 110        
 Asn Leu Gln Val Arg Ser Lys Thr
         115                 120



      <210> 1481
      <211> 136
      <212> PRT
      <213> Homo sapiens


      <400> 1481
 Met Asp Phe Ser Leu Cys Val Ser Leu Thr Thr Ile Ala Thr Leu Tyr
   1               5                  10                  15    
 Leu Ala Gly Gln Ser Ala Cys Lys Ala Val Asp Leu Gln Glu Asn Gln
              20                  25                  30        
 Lys Arg Arg Cys Thr Thr Lys Lys Glu Lys Glu Lys Leu Met Cys Leu
          35                  40                  45            
 Thr Gly Leu Phe Gln Glu Thr Cys Glu Glu Ala Lys Ala Asp Asn Glu
      50                  55                  60                
 Pro Ser Cys Ser Pro Ala Ala Gln Glu Leu Leu Thr Arg Leu Gly Phe
  65                  70                  75                  80
 Leu Leu Gly Glu Gly Ile Pro Ser Ala Thr His Ile Thr Ile Glu Asp
                  85                  90                  95    
 Lys Asn Glu Thr Met Val Met Pro Glu Glu Asp Thr Thr Leu His Thr
             100                 105                 110        
 Ser Ser Glu Asp Glu Arg Ser Asn Asn His Leu Leu Pro Phe Leu Glu
         115                 120                 125            
 Gln Gly Ser His Cys Ser Val Lys
     130                 135    



      <210> 1482
      <211> 517
      <212> PRT
      <213> Homo sapiens


      <400> 1482
 Met Asp Arg Ile Leu Gly Leu Val Pro Val Thr Leu Trp Ile Arg Arg
   1               5                  10                  15    
 Ala Ile Trp Ala Cys Thr Ala Val Val Ala Phe Met Val Arg Arg Arg
              20                  25                  30        
 His Ala Val Arg Arg Arg Glu Glu Leu Ala Gln Arg Asp Ser Ala Gln
          35                  40                  45            
 Gly Glu Val His Gly Lys Ala Arg Ala Lys Met Gln Pro Ala Pro Gln
      50                  55                  60                
 Ala Gly Gly Gly Leu Thr Ser Pro Met Pro Glu Val Ser Pro Arg Leu
  65                  70                  75                  80
 Leu Gln Thr Leu Cys Ser Arg Val Gln Lys Glu Met Ser Arg Ser Ser
                  85                  90                  95    
 His Gln Gly Pro Asp Glu Leu Leu Lys Thr Ser Val Thr Lys Gln Pro
             100                 105                 110        
 Pro Glu His Pro Gly Met Thr Asp Ala Lys Tyr Thr Pro His Gly Ser
         115                 120                 125            
 Gln His Glu Asp His Gln Gly Gln Thr Val Asp Asp Leu Asn Asp Ser
     130                 135                 140                
 Thr Asp Arg Gln Gln Pro Ala Glu Leu Pro Gly Gln Glu Ile Thr Arg
 145                 150                 155                 160
 Arg Lys Gln Arg Leu Gln Ala Lys Glu Glu Lys Lys Glu Arg Pro Glu
                 165                 170                 175    
 Gln Ala Gly Ala Gly Val Glu Arg Ala Ala Asn Val Gly Val Lys Cys
             180                 185                 190        
 Arg Pro Ser Trp Pro Thr Pro Leu Arg Ala Cys Ala Arg Gly Gln Cys
         195                 200                 205            
 Lys Glu Leu Thr Ala Glu Val Gln Ser Leu Pro Ala Gly Leu Pro Ala
     210                 215                 220                
 Gly His Glu Gly Thr Ala Gly Glu Gly Ala Ser Lys Thr Ala Ala Glu
 225                 230                 235                 240
 Gly Ser Arg Cys Leu His Cys Thr Glu Asn Ser Arg Asp Gly Val Ser
                 245                 250                 255    
 Arg Glu Ser Thr Glu Glu Asn Ala Tyr Cys Leu Asp Leu Asp Gln Arg
             260                 265                 270        
 Leu Arg Lys Val His Glu Asn Thr Cys Asn His Tyr Lys Lys Met Thr
         275                 280                 285            
 Gln Asp Leu Ala Gln Glu Ser Lys Lys Asp Thr Ser Asn Phe Gln Arg
     290                 295                 300                
 Glu Ile Phe Phe Arg Glu Lys Met Ala Gln Glu Gly Arg Met Ala Ala
 305                 310                 315                 320
 Val Ser Thr Glu Thr Ala Leu Gln Pro Leu Arg Glu Glu Asn Asp His
                 325                 330                 335    
 Ser Arg Gln Lys Pro Ala Asp Phe Glu Ala Lys Phe Gln Leu Leu Arg
             340                 345                 350        
 Gly Gly Ala Leu Ala Pro Gly Val Leu Pro Ala Ala His Arg Gly Pro
         355                 360                 365            
 Glu Val Ser Gly Gly Pro Trp Asp Asp Arg Ala Pro Arg Arg Glu Ala
     370                 375                 380                
 Gly His Asn Gln Ser Glu Asp Val Gly Glu Ser Tyr Ser Gln Glu Tyr
 385                 390                 395                 400
 Leu Val Asp Ser Gln Phe Glu Glu Ser Pro Pro Trp Ala His Gly Leu
                 405                 410                 415    
 Gln Glu Ala Arg Gly Pro Gly Lys Ala Ile Ala Gly Val Pro Val Arg
             420                 425                 430        
 Ser Glu Glu Gly Val Thr Ala Ala Glu Ala Ala Asp Trp Gln Glu Val
         435                 440                 445            
 Pro Leu Lys Asp Ala Lys Glu Tyr Ala Glu Ser Ile Gly Ala Ile Val
     450                 455                 460                
 Val Glu Thr Ser Ala Lys Asn Ala Ile Asn Ile Glu Glu Leu Phe Gln
 465                 470                 475                 480
 Gly Ile Ser Ala Met Leu Asp Pro Gly Asp Ser Thr Val Thr Arg Arg
                 485                 490                 495    
 Ser Asp Ser Gly Val Gly Glu Thr Ala Val Gly Thr Val Arg Ser Val
             500                 505                 510        
 Ser Gly Asp Ser Trp
         515        



      <210> 1483
      <211> 225
      <212> PRT
      <213> Homo sapiens


      <400> 1483
 Met Leu Leu Arg Leu Phe Trp Asn Phe Trp Ala Gln Ala Ile Leu Leu
   1               5                  10                  15    
 Leu Gln Pro Pro Lys Val Leu Gly Leu Gln Val Tyr Lys Pro Ile Arg
              20                  25                  30        
 Val Glu Asp Ile Asn Asn Ile Ile Arg Ile Ala Leu Tyr Ile Thr Ala
          35                  40                  45            
 Arg Val Trp Lys Leu Pro Thr Tyr Leu Arg Thr Glu Glu Gln Leu Gly
      50                  55                  60                
 Gly Leu Met Pro Glu Cys Gln Gly Ala Leu Asn Arg Pro Pro Phe Leu
  65                  70                  75                  80
 Pro Trp Gly Lys Gln Asn Glu Thr Glu Pro Gly Arg Thr Cys Ala Val
                  85                  90                  95    
 Arg Gln Arg Met Glu Glu Glu Asn Thr Lys Ser Gln Glu Gln Leu Glu
             100                 105                 110        
 Ala Asn Phe Glu Ser Pro Gln Leu Pro Val His Ser Thr Gln Arg Ile
         115                 120                 125            
 Arg Asp Lys Asn Asp Cys Ser Glu Gly Leu Glu Ser Ala Gly Ser His
     130                 135                 140                
 Leu Gln Val Leu Gln Pro Gly His Phe Asn Ser Ser Ser Ser Ile Leu
 145                 150                 155                 160
 Lys Ile Asn Ser Ala Arg Thr Trp Met Glu Leu Glu Val Ile Ile Leu
                 165                 170                 175    
 Ser Lys Leu Arg Gln Lys Gln Lys Asn Gln Thr Leu His Val Leu Thr
             180                 185                 190        
 Asp Lys Trp Glu Leu Asn Asp Gly Asn Thr Trp Thr His Ser Gly Lys
         195                 200                 205            
 Gln His Thr Leu Gly Ser Gly Gly Gly Lys Glu Ser Ile Arg Lys Asn
     210                 215                 220                
 Ser
 225



      <210> 1484
      <211> 283
      <212> PRT
      <213> Homo sapiens


      <400> 1484
 Met Thr Cys Leu Tyr Ser Leu Leu Thr Ala Val Tyr Lys Tyr Ser Gln
   1               5                  10                  15    
 Leu Ala Leu Ile Met Glu Thr Gly Pro Ser Arg Trp Arg Asp Thr Val
              20                  25                  30        
 Pro Val Arg Arg Gly Gly Glu Cys Ala Cys Gln Glu Val Gly Val Ala
          35                  40                  45            
 Val Gln Met Ala Val Pro Ser Ser Arg Leu Arg Ala Gly Ser Ala Arg
      50                  55                  60                
 Asp Pro Leu Ala Ile Pro Thr Val Val Tyr Gly Gln Leu Met Val Tyr
  65                  70                  75                  80
 Phe Leu Gln Phe Pro Val Ser Asp Lys Gly Lys His Gly Gln Asp Gly
                  85                  90                  95    
 Ser Val Ser Gln Ala Gln Lys Gly Thr Thr Val Pro Ala His Arg Ala
             100                 105                 110        
 Ile Leu Val Ala Arg Cys Glu Val Met Ala Ala Met Phe Asn Gly Asn
         115                 120                 125            
 Tyr Met Glu Ala Lys Ser Val Leu Ile Pro Val Tyr Gly Val Ser Lys
     130                 135                 140                
 Glu Thr Phe Leu Ser Phe Leu Glu Tyr Leu Tyr Thr Asp Ser Cys Cys
 145                 150                 155                 160
 Pro Ala Gly Ile Phe Gln Ala Met Cys Leu Leu Ile Cys Ala Glu Met
                 165                 170                 175    
 Tyr Gln Val Ser Arg Leu Gln His Ile Cys Glu Leu Phe Ile Ile Thr
             180                 185                 190        
 Gln Leu Gln Ser Met Pro Ser Arg Glu Leu Ala Ser Met Asn Leu Asp
         195                 200                 205            
 Ile Val Asp Leu Leu Lys Lys Ala Lys Glu Tyr Ile Cys Ser Ile Thr
     210                 215                 220                
 Thr Glu Cys Gln Tyr Phe Leu Asn Tyr Tyr Leu Ala Ser Asn Met Ser
 225                 230                 235                 240
 Ile Pro Ile Asn Phe Asp Val Gln Gly Tyr Lys Ser Met Thr Thr Phe
                 245                 250                 255    
 Ile Ser Ile His Ile Ala Lys Met Glu Pro His Asp Gly Ala Asn Ser
             260                 265                 270        
 Arg Ser Val Thr Ala Glu Cys Leu Pro Pro Ser
         275                 280            



      <210> 1485
      <211> 341
      <212> PRT
      <213> Homo sapiens


      <400> 1485
 Met Thr Ala Arg Cys Met Leu Ser Arg Leu Ile Leu Leu Asn Arg His
   1               5                  10                  15    
 Arg Ala Val His Met Leu Ser Gly Ser Cys Gly Glu Leu His Val Thr
              20                  25                  30        
 Gln Ala Ala His Leu Phe Gln Leu Leu Leu Val Leu Asn Lys Leu Pro
          35                  40                  45            
 Pro Asn Leu Val Ala Leu Lys Glu Gln Gln Ser Phe Ile Ser Ser Asn
      50                  55                  60                
 Leu Gln Phe Glu Gln Asp Phe Ala Glu His Phe Ile Ser Ala Ala His
  65                  70                  75                  80
 Ser Ala Cys Gln Val Gly Gln Gln Gly Pro Gln His Pro Leu Pro Arg
                  85                  90                  95    
 Trp Leu Ile Arg Met Thr Gly Ser Cys Gly Arg Trp Val Leu Ser Pro
             100                 105                 110        
 Asp Gln Cys Gln Leu Met Gly Lys Arg Cys Leu Glu His Ser Val Glu
         115                 120                 125            
 Lys Asp Ser Gln Ser Leu Gly Ser Thr Arg Lys Asp Ile Thr Ile Ala
     130                 135                 140                
 Ala Val Gln Ser Asn Ile Ala Ala Leu Ala Pro Ala Gln Pro Val Lys
 145                 150                 155                 160
 Pro Leu Arg Arg Ala Leu Ser Arg Gly Phe Pro Val Ile Asp His Thr
                 165                 170                 175    
 Ser Ala Arg Leu Arg Phe Ser Lys Pro Leu Val Asn Cys Pro Leu Gly
             180                 185                 190        
 Thr Glu Gly Ser His Ser Arg Gln Lys Lys Thr Phe Phe Leu Gly Asp
         195                 200                 205            
 Gly Gln Lys Leu Lys Asp Trp His Asp Lys Glu Ala Ile Arg Arg Asp
     210                 215                 220                
 Ala Gln Arg Val Gly Thr Glu Gly Arg Ile Gly His Gly Ile Glu Met
 225                 230                 235                 240
 Ser Leu Pro Tyr Glu Ile Thr Thr Lys Thr Arg Ser Ser Asn Lys Ser
                 245                 250                 255    
 Gln His Leu Leu Asn Thr Tyr Gly Asn Gly Glu Gln Gly Arg Pro Tyr
             260                 265                 270        
 Pro Met Thr Asp Ala Glu Arg Val Asp Gln Ala Tyr Arg Glu Asn Gly
         275                 280                 285            
 Phe Asn Ile Tyr Val Ser Asp Lys Ile Ser Leu Asn Arg Ser Leu Pro
     290                 295                 300                
 Asp Ile Arg His Pro Lys Ser Cys Thr Gly Asp Cys Val Ala Arg Glu
 305                 310                 315                 320
 Arg Lys Arg Gly Ser Leu Ala Gln Thr His Trp Thr Cys Lys Trp Glu
                 325                 330                 335    
 Ser Ala Ser Trp Leu
             340    



      <210> 1486
      <211> 285
      <212> PRT
      <213> Homo sapiens


      <400> 1486
 Met Glu Ile Pro Ala Val Ile Leu Thr Val Ala Pro Ile Leu His Leu
   1               5                  10                  15    
 Thr Ser Cys Gly Phe Pro Val Thr Gly Asp Gly Leu Lys Gln Ala Glu
              20                  25                  30        
 Gly Lys Cys Ala Pro Glu Glu Trp Asn Pro Thr Lys Phe Ile Lys Leu
          35                  40                  45            
 Thr Asp Asn Gln Ala Cys Phe Ala Cys Gly Leu Trp Pro Leu Ser Glu
      50                  55                  60                
 Ile Gln Arg Arg Thr Ser Arg Thr Val Thr Ile Ile Ser Arg Ile Ser
  65                  70                  75                  80
 Ala Leu Arg Glu Lys Gly Asn Gly Arg Lys Pro Thr Ser Ile Ser Gly
                  85                  90                  95    
 Ser Val Asn Glu Met Arg Gln Val Leu Val Lys Asp Gln Val Ser Met
             100                 105                 110        
 Pro Arg Val Leu Pro Thr Ile Ile Phe Val Pro Asp Glu Ala Gly Phe
         115                 120                 125            
 Ser Ala Gly Ala Val Trp Pro Cys Ala Ala Pro Leu Trp Gly Ser Ser
     130                 135                 140                
 Trp Thr Pro Leu Lys Val Glu Asn Cys Ser Phe Tyr Ile Arg Leu Ser
 145                 150                 155                 160
 Phe Ala Ile Ser Val Gly Gly Asp Glu Leu Lys Ile Ala Lys Leu Val
                 165                 170                 175    
 Ser Ala Phe Pro Glu Arg Ala Tyr Asp Leu Val Gly His Gln His Gln
             180                 185                 190        
 Arg Pro Lys Val Asp Lys Thr Thr Lys Met Gly Arg Asn Gln Ser Arg
         195                 200                 205            
 Lys Ala Glu Asn Ser Lys Asn Gln Asn Met Ser Ser Pro Pro Lys Glu
     210                 215                 220                
 His Asn Ser Ser Pro Ala Arg Glu Gln Asn Trp Met Glu Asn Glu Phe
 225                 230                 235                 240
 Asp Glu Leu Arg Glu Val Gly Phe Arg Arg Pro Leu Gly Asn Gly His
                 245                 250                 255    
 Pro Tyr Cys Thr Glu Ile Pro Tyr Pro Ser Val Ser Phe Ile Thr Ala
             260                 265                 270        
 Lys Lys Gly Gly Asp Gln Met Lys His Thr Lys Val Glu
         275                 280                 285



      <210> 1487
      <211> 539
      <212> PRT
      <213> Homo sapiens


      <400> 1487
 Met Leu Ser Lys Leu Gly Ile Glu Arg Asn Cys Leu Ile Arg Asn Pro
   1               5                  10                  15    
 Arg Val Asn Thr Ile Leu His Gly Lys Arg Leu Lys Ala Ser Ala Thr
              20                  25                  30        
 Thr Gly Asn Arg Pro Arg Cys Leu Leu Ala Leu Leu Leu Leu Ser Ile
          35                  40                  45            
 Met Leu Gly Val Pro Gly Tyr Val Gln Ala Ser Lys Arg Asp Lys Lys
      50                  55                  60                
 Phe Phe Ala Cys Ala Pro Asn Tyr Ser Tyr Ala Ala Leu Cys Glu Cys
  65                  70                  75                  80
 Leu Arg Arg Val Phe Ile Tyr Arg Gln Pro Ala Pro Met Ser Thr Val
                  85                  90                  95    
 Leu Tyr Asn Arg Lys Glu Gly Arg Gln Val Gly Gln Val Ala Lys Gln
             100                 105                 110        
 Gln Val Ala Ser Leu Glu Thr Asn Asp Pro Ile Leu Gly Phe Gln Ala
         115                 120                 125            
 Thr Asn Glu Arg Leu Phe Val Leu Thr Thr Lys Asn Leu Phe Leu Ile
     130                 135                 140                
 Lys Leu Leu Glu Val Ala Tyr Met Gly His Gly Thr Leu Pro Ser Ser
 145                 150                 155                 160
 Lys Leu Ala Ile Ala Asp Phe Gly Gln Met Cys Ser Phe Thr Ile Gly
                 165                 170                 175    
 Ser Leu Leu Ala Tyr Asn Glu Gly Asp Tyr Thr Asn Gly Tyr Thr Leu
             180                 185                 190        
 Asn Phe Leu Thr Gly Val Pro Gly Gln Ile Phe Tyr Ala Glu Glu Arg
         195                 200                 205            
 Pro Gly Cys Thr Ser Val Ala Ser Ala Phe Ala Leu Leu Met Lys Lys
     210                 215                 220                
 Leu Leu Leu Met Ala Glu Asp Glu Gly Gly Thr Gly Leu Ser His Gly
 225                 230                 235                 240
 Lys Arg Gly Asn Lys Arg Lys Glu Glu Val Ser Ile Ile Leu Ile Pro
                 245                 250                 255    
 Lys Ala Ser Arg Asp Thr Thr Glu Lys Glu Tyr Phe Arg Thr Ile Ser
             260                 265                 270        
 Leu Met Asn Ile Asp Ala Lys Ile Phe Asn Lys Ile Leu Ala Asn Gln
         275                 280                 285            
 Ile Gln Gln His Ile Lys Lys Leu Phe His His Gly Gln Val Gly Phe
     290                 295                 300                
 Ile His Gly Met Gln Gly Trp Phe Asn Ile Gln Lys Ser Ile Asn Val
 305                 310                 315                 320
 Ile His His Ile Asn Arg Thr Asn Asp Lys Asn His Met Ile Val Ser
                 325                 330                 335    
 Ile Asp Ala Glu Lys Ala Phe Asp Lys Ile Gln His Leu Phe Met Leu
             340                 345                 350        
 Lys Thr Leu Ser Lys Leu Gly Ile Asp Gly Met Tyr Leu Lys Ile Ile
         355                 360                 365            
 Arg Ala Ile Tyr Asp Lys Leu Thr Ala Asn Thr Ile Leu Asn Gly Gln
     370                 375                 380                
 Lys Leu Glu Ala Phe Pro Leu Lys Thr Ser Thr Arg Gln Gly Cys Pro
 385                 390                 395                 400
 Leu Ser Pro Leu Ser Phe Asn Ile Val Leu Glu Val Leu Thr Arg Ala
                 405                 410                 415    
 Ile Arg Gln Glu Lys Glu Ile Lys Cys Ile Gln Ile Gly Arg Glu Glu
             420                 425                 430        
 Val Lys Leu Ser Leu Phe Ala Asp Asp Met Ile Val Tyr Leu Glu Asn
         435                 440                 445            
 Pro Ile Val Ser Val Gln Asn Leu Leu Lys Leu Ile Ser Asn Phe Ser
     450                 455                 460                
 Lys Val Ser Glu Tyr Lys Ile Asn Val Gln Lys Ser Gln Ala Phe Leu
 465                 470                 475                 480
 Tyr Thr Ser Asn Ser Gln Ile Ile Ser Glu His Pro Phe Thr Ile Ala
                 485                 490                 495    
 Thr Asn Arg Ile Lys Tyr Leu Gly Ile Gln Phe Thr Lys Asp Val Lys
             500                 505                 510        
 Asp Leu Phe Lys Glu Asn Tyr Lys Gln Leu Leu Lys Glu Ile Arg Lys
         515                 520                 525            
 Asp Thr Asn Lys Trp Lys Asn Ile Pro Cys Ser
     530                 535                



      <210> 1488
      <211> 335
      <212> PRT
      <213> Homo sapiens


      <400> 1488
 Met Lys Leu Ala Ser Gly Phe Leu Val Leu Trp Leu Ser Leu Gly Gly
   1               5                  10                  15    
 Gly Leu Ala Gln Ser Asp Thr Ser Pro Asp Thr Glu Glu Ser Tyr Ser
              20                  25                  30        
 Asp Trp Gly Leu Arg His Leu Arg Gly Ser Phe Glu Ser Val Asn Ser
          35                  40                  45            
 Tyr Phe Asp Ser Phe Leu Glu Leu Leu Gly Gly Lys Asn Gly Val Cys
      50                  55                  60                
 Gln Tyr Arg Cys Arg Tyr Gly Glu Cys Ala Val Ser Leu Ser Val Lys
  65                  70                  75                  80
 Thr Val Ala Gly Gly Pro Met Asp Ser Pro Arg Glu Val Thr Ile Cys
                  85                  90                  95    
 Leu Ala Leu Phe Pro Val Ile His Leu Glu Leu Pro Asp Leu Ala Asp
             100                 105                 110        
 Lys Asn Gln Asn Ser Ile Lys Arg Leu Lys Gln Ile Leu Val Ala Glu
         115                 120                 125            
 Pro Leu Ala Gly Gln Gly Gly Ser Gln Gln Gln Leu Gly Lys Lys Ser
     130                 135                 140                
 Lys Trp Phe Glu Ser His Tyr Ser Ser Val Thr Ser Ser Ser Ser Ser
 145                 150                 155                 160
 Ser Pro Asp Leu Asp Met Asp Leu Gly Ile Pro Ala Met Thr Lys Cys
                 165                 170                 175    
 Cys Asn Gln Leu Asp Val Cys Tyr Asp Thr Cys Gly Ala Asn Lys Tyr
             180                 185                 190        
 Arg Cys Asp Ala Lys Phe Arg Trp Cys Leu His Ser Ile Cys Ser Asp
         195                 200                 205            
 Leu Lys Arg Ser Leu Gly Phe Val Ser Lys Val Glu Val Lys Ala Ile
     210                 215                 220                
 Gly Glu Ile Arg Cys Val Leu Gly Gly Met Ala Ile Asp Gly Lys Ala
 225                 230                 235                 240
 Met Gly Asn Ile Val Val His Glu Leu Arg Lys Lys Lys Lys Glu Lys
                 245                 250                 255    
 Gly Phe Phe Ser Ser Asn Gly Glu Arg Cys Gln Glu Arg Leu His Gly
             260                 265                 270        
 Gly Ser Lys Pro Ser Met Asn Leu Glu Glu Pro Val Arg Ile Arg Gln
         275                 280                 285            
 Glu Glu Lys Ala Gly Lys Lys Ile Ser Gly Arg Gly Asn Ser Met Arg
     290                 295                 300                
 Lys Val Arg Arg Val Phe Arg Ser Asp Ser Leu Gly Ile Val Asn Asn
 305                 310                 315                 320
 Ser Leu Trp Gln Glu Gln Lys Leu Glu Gly Ala Glu Val Arg Gly
                 325                 330                 335



      <210> 1489
      <211> 703
      <212> PRT
      <213> Homo sapiens


      <400> 1489
 Met Ser Arg Leu Leu Gly Gly Thr Leu Glu Arg Val Cys Lys Ala Val
   1               5                  10                  15    
 Leu Leu Leu Cys Leu Leu His Phe Leu Val Ala Val Ile Leu Tyr Phe
              20                  25                  30        
 Asp Val Tyr Ala Gln His Leu Ala Phe Phe Ser Arg Phe Ser Ala Arg
          35                  40                  45            
 Gly Pro Ala His Ala Leu His Pro Ala Ala Ser Ser Ser Ser Ser Ser
      50                  55                  60                
 Ser Asn Cys Ser Arg Pro Asn Ala Thr Ala Ser Ser Ser Gly Leu Pro
  65                  70                  75                  80
 Glu Val Pro Ser Ala Leu Pro Gly Pro Thr Ala Pro Thr Leu Pro Pro
                  85                  90                  95    
 Cys Pro Asp Ser Pro Pro Gly Leu Val Gly Arg Leu Leu Ile Glu Phe
             100                 105                 110        
 Thr Ser Pro Met Pro Leu Glu Arg Val Gln Arg Glu Asn Pro Gly Val
         115                 120                 125            
 Leu Met Gly Gly Arg Tyr Thr Pro Pro Asp Cys Thr Pro Ala Gln Thr
     130                 135                 140                
 Val Ala Val Ile Ile Pro Phe Arg His Arg Glu His His Leu Arg Tyr
 145                 150                 155                 160
 Trp Leu His Tyr Leu His Pro Ile Leu Arg Arg Gln Arg Leu Arg Tyr
                 165                 170                 175    
 Gly Val Tyr Val Ile Asn Gln Ala Ser Pro His Gly Gly Ala Gly Leu
             180                 185                 190        
 Gly Tyr Ala Val Gly Gly Asp Val Glu Gly Pro Glu Glu Arg Glu Leu
         195                 200                 205            
 Asp Pro Glu Arg Arg Met Lys Pro Val Glu Pro Phe Gly His Gly Glu
     210                 215                 220                
 Asp Thr Phe Asn Arg Ala Lys Leu Leu Asn Val Gly Phe Leu Glu Ala
 225                 230                 235                 240
 Leu Lys Glu Asp Ala Ala Tyr Asp Cys Phe Ile Phe Ser Asp Val Asp
                 245                 250                 255    
 Leu Val Pro Met Asp Asp Arg Asn Leu Tyr Arg Cys Gly Asp Gln Pro
             260                 265                 270        
 Arg His Phe Ala Ile Ala Met Asp Lys Phe Gly Phe Arg Leu Pro Tyr
         275                 280                 285            
 Ala Gly Tyr Phe Gly Gly Val Ser Gly Leu Ser Lys Ala Gln Phe Leu
     290                 295                 300                
 Arg Ile Asn Gly Phe Pro Asn Glu Tyr Trp Gly Trp Gly Gly Glu Asp
 305                 310                 315                 320
 Asp Asp Ile Phe Asn Arg Ile Ser Leu Thr Gly Met Lys Ile Ser Arg
                 325                 330                 335    
 Pro Asp Ile Arg Ile Gly Arg Tyr Arg Met Ile Lys His Asp Arg Asp
             340                 345                 350        
 Lys His Asn Glu Pro Asn Pro Gln Arg Phe Thr Lys Ile Gln Asn Thr
         355                 360                 365            
 Lys Leu Thr Met Lys Arg Asp Gly Ile Gly Ser Val Arg Tyr Gln Val
     370                 375                 380                
 Leu Glu Val Ser Arg Gln Pro Leu Phe Thr Asn Ile Thr Val Asp Ile
 385                 390                 395                 400
 Gly Arg Pro Pro Ser Ser Glu Pro Gly Thr Ala Ala Ser Val Gly His
                 405                 410                 415    
 Ala Pro Ala Leu Pro Leu Ala Val Gly Ala Gly Gly Gly Ala Arg Ser
             420                 425                 430        
 Ala Pro Gly Ala Thr Arg Ser Glu Glu Asp Leu Gly Glu Ala Ala Val
         435                 440                 445            
 Asp Leu Ser Leu Glu Leu Arg Ala Glu Val Ala Met Leu Arg Ala Leu
     450                 455                 460                
 Leu Gln Glu Ala Arg Ser Ser Gln Ala Pro Ser Ser Arg Pro Ile Ser
 465                 470                 475                 480
 Asp Pro Ser Ser Leu Leu Ala Pro Pro Pro Leu Leu Lys Asp Leu Leu
                 485                 490                 495    
 Arg Gln Glu Leu Arg Gln Leu Leu Gln Gly Leu Arg His Lys Ala Ile
             500                 505                 510        
 Cys Glu Gly Arg Asp Gln Ala Gln Ala Trp Val Gln Tyr Ser Pro Arg
         515                 520                 525            
 Val Leu His Phe Ala Leu Glu Glu Pro Arg Cys Asp Leu Pro Glu Gln
     530                 535                 540                
 Glu Ile Phe Gln Met Arg Gly Gly Gly Pro Ser Gly His Arg Asp Leu
 545                 550                 555                 560
 Ser Ile Ile Lys Asp Gln Leu Asn Val Ser Asn Ile Asp Gln Val Ala
                 565                 570                 575    
 Arg His Leu Arg Gly Leu Leu Glu Glu Glu Cys His Thr Leu Glu Arg
             580                 585                 590        
 Glu Ile Leu Ile Leu Gln Arg Cys Leu Glu Glu Glu Tyr Leu Arg Pro
         595                 600                 605            
 Cys His Pro Ser Glu Ala Ala Leu Glu Pro Thr Leu Ala Glu Leu Lys
     610                 615                 620                
 Glu Gln Lys Lys Ala Met Glu Gln Glu Leu Gln Ala Ser Val Gly Pro
 625                 630                 635                 640
 Ser Cys Val Ser Pro Asn His Ser Ala Ala Cys Leu His Leu Leu Trp
                 645                 650                 655    
 Ser Pro Thr Phe Asp Leu Glu Ala Ser Arg Leu Pro Thr Ala Gly Asp
             660                 665                 670        
 Gly Ser Phe Ser Ala Ala Pro Gly Lys Gly Gln Leu Pro His Pro Cys
         675                 680                 685            
 Pro Val Gln His Pro Lys Pro Gln Pro Glu Gly Leu Val Thr Glu
     690                 695                 700            



      <210> 1490
      <211> 154
      <212> PRT
      <213> Homo sapiens


      <400> 1490
 Met Val Gln Leu Leu Trp Lys Thr Ala Trp Gln Phe Leu Thr Lys Leu
   1               5                  10                  15    
 Asn Leu Leu Leu Pro Tyr Asp Pro Ala Ile Thr Leu Leu Val Ile His
              20                  25                  30        
 Pro Asp Glu Leu Gln Ile Tyr Val Arg Thr Lys Thr Cys Thr Asp Val
          35                  40                  45            
 His Ser Ser Phe Ile His Asn Cys Gln Asn Leu Glu Ala Thr Lys Ile
      50                  55                  60                
 Ser Phe Arg Arg Phe Gly Leu Glu Thr Ala Val Ser Asn Leu Glu His
  65                  70                  75                  80
 Pro Glu Gln Lys Ala Leu Ser Val Ser Leu Pro Gln Lys Leu Leu Arg
                  85                  90                  95    
 Lys Leu Ser Ala Gly Ala Val Met Pro Pro Thr Ala Leu Phe Leu Val
             100                 105                 110        
 Lys Arg Thr Phe Gln Gly Cys Ala Ser Asp Glu Gly Ala Ser Arg Leu
         115                 120                 125            
 Gly Leu Lys Thr Tyr Ile Val Ser Asp Asn Gln Ala Thr Ser Thr Arg
     130                 135                 140                
 Leu Pro Asp Leu Gly Phe Ser Ala Gly Leu
 145                 150                



      <210> 1491
      <211> 363
      <212> PRT
      <213> Homo sapiens


      <400> 1491
 Met Val Gly Arg Arg Thr Gly Lys Pro Ala Tyr Ser His Phe Leu Leu
   1               5                  10                  15    
 Leu Thr Leu Cys Ser Leu Gly Pro Lys Ala Glu Glu Ile Leu Gln Thr
              20                  25                  30        
 Tyr Leu Lys Ser Lys Glu Ser Val Thr Asp Ala Ile Leu Gln Thr Asp
          35                  40                  45            
 Gln Ile Leu Thr Glu Lys Glu Lys Glu Ile Glu Val Glu Cys Val Lys
      50                  55                  60                
 Ala Glu Ser Ala Gln Ala Ser Ala Lys Met Val Glu Glu Met Gln Ile
  65                  70                  75                  80
 Lys Tyr Gln Gln Met Met Glu Glu Lys Glu Lys Ser Tyr Gln Glu His
                  85                  90                  95    
 Val Lys Gln Leu Thr Glu Lys Met Glu Arg Glu Arg Ala Gln Leu Leu
             100                 105                 110        
 Glu Glu Gln Glu Lys Thr Leu Thr Ser Lys Leu Gln Glu Ala Ile Pro
         115                 120                 125            
 Ile Gly Lys Gly Gly Glu Tyr Tyr Ile Arg Gly Thr Pro His Gly Thr
     130                 135                 140                
 Lys Glu Ser Glu Gln Gln Pro Ser Ala Leu Asp Leu Leu Ser Asp Arg
 145                 150                 155                 160
 Ala Tyr Pro Asn Glu Lys Glu Pro Glu Asn Gln Leu Trp Leu Tyr Asp
                 165                 170                 175    
 Lys Thr Arg Pro Phe Asn Thr Pro Gln Lys Ser Ser Trp Phe Thr Ser
             180                 185                 190        
 Asn Gly Ser Lys Pro Arg Arg Asn Pro Asp Leu Ser Glu Lys Glu Phe
         195                 200                 205            
 Arg Arg Leu Val Thr Lys Leu Ile Arg Glu Gly Pro Glu Lys Glu Met
     210                 215                 220                
 Gln Asn Ala Leu Glu Ser Leu Ser Asn Arg Ile Glu Gln Val Gln Glu
 225                 230                 235                 240
 Arg Asn Ser Glu Leu Lys Asp Lys Val Phe Glu Leu Thr Gln Ser Asn
                 245                 250                 255    
 Lys Asp Lys Glu Lys Arg Ile Arg Lys Tyr Glu Gln Ile Leu Gln Glu
             260                 265                 270        
 Glu Thr His Arg Thr His Lys Asp Ser His Lys Val Lys Val Asn Gly
         275                 280                 285            
 Trp Lys Lys Pro Phe His Ala Asn Gly His Gln Lys Arg Pro Glu Ala
     290                 295                 300                
 Pro Ser Lys Val Ile Pro Thr Arg Ser Leu His Leu Tyr Lys Pro Ser
 305                 310                 315                 320
 Gly Pro Thr Ala Cys Pro Ser Leu Gln Thr Ser Pro Arg Pro Ile Thr
                 325                 330                 335    
 Cys Pro Asn Pro Ile Ser Arg Ile His Pro Ile Arg Ala Leu Gly Pro
             340                 345                 350        
 Asn Ser Ile Pro Ile Ser Lys Ser Pro Pro His
         355                 360            



      <210> 1492
      <211> 551
      <212> PRT
      <213> Homo sapiens


      <400> 1492
 Met Val Phe Ser Ser Ile Met Ser Phe Lys Val Leu Ser Thr Leu Phe
   1               5                  10                  15    
 Ile Leu Val Ser His Ser Ser Asn Leu Phe Ser Arg Phe Leu Pro Ser
              20                  25                  30        
 Leu Gln Trp Val Gln Thr Ser Ser Phe Ser Ser Glu Lys Phe Val Ile
          35                  40                  45            
 Thr Asp Leu Leu Lys Pro Thr Ser Val Asn Leu Ser Lys Ser Phe Ser
      50                  55                  60                
 Val Gln Leu Ser Ser Ile Ala Gly Leu Leu Glu Phe Ala Gly Gly Pro
  65                  70                  75                  80
 Leu Tyr Gly Tyr Pro Val Cys Leu Gly Ile Thr Ser Glu Arg Cys Arg
                  85                  90                  95    
 Thr Glu His Gln Ile Leu Gln Asn Ser Lys Cys Cys Cys Leu Ile Leu
             100                 105                 110        
 Pro Leu Glu Ala Ser Ser Gln Arg Ser Ser Trp Leu Tyr Glu Val Ser
         115                 120                 125            
 Glu Val Met Ala Glu His Asn Pro Gln Tyr Leu Ile Glu Leu Asn Gly
     130                 135                 140                
 Asn Lys Pro Ala Glu Glu Leu Phe Met Asp Glu Leu Phe Arg Thr Leu
 145                 150                 155                 160
 Ala Ser Tyr Lys Leu Ile Ala Pro Arg Tyr Arg Trp Gln Arg Ser Lys
                 165                 170                 175    
 Trp Gly Arg Thr Cys Pro Val Asn Leu Lys Asp Gly Asn Ile Tyr Ser
             180                 185                 190        
 Gly Leu Pro Asp Tyr Ser Lys Thr Leu Thr Val Lys Gln Pro Gln Ala
         195                 200                 205            
 Gly Ser Ser Gly Asp Ile Pro Glu Gly Ile Val Val Val Arg Asp Asp
     210                 215                 220                
 Ser Ser Met His Val Leu Val Pro Glu Asp Leu Pro Val Gly Gln Asp
 225                 230                 235                 240
 Ile Glu Glu Glu Asp Ser Asp Ile Asp Asn Pro Asp Pro Ile Leu Glu
                 245                 250                 255    
 Phe Val Glu Glu Leu Glu Asp Arg Ser Ile Lys His Phe Gln Ser Glu
             260                 265                 270        
 Lys Gln Arg Glu Lys Lys Ile Leu Lys Glu Met Asn Arg Ala Ser Gly
         275                 280                 285            
 Thr Cys Gly Lys Ile Arg Trp Ser Asn Val Val Asp Tyr Ala Gln Leu
     290                 295                 300                
 Val Gln Pro Arg Phe Asp Lys Ala Arg Glu Thr Leu Val Glu Asn Thr
 305                 310                 315                 320
 Ile Ala Glu Ala Thr Ala Ala Ala Ile Lys Val Val Lys Glu Lys Leu
                 325                 330                 335    
 Leu Arg Glu Leu Gln Ala Arg Lys Gln Ala Glu Thr Ala Leu Arg Glu
             340                 345                 350        
 Phe Gln Arg Gln Tyr Glu Lys Met Glu Phe Gly Val Phe Pro Met Glu
         355                 360                 365            
 Ala Thr His Ser Ser Ile Asp Glu Glu Gly Tyr Ile Gln Gly Ser Gln
     370                 375                 380                
 Arg Asp Arg Gly Ser Ser Leu Val Asp Thr Glu Glu Ala Lys Thr Lys
 385                 390                 395                 400
 Ser Glu Asn Val Leu His Asp Gln Ala Ala Lys Val Asp Lys Asp Gly
                 405                 410                 415    
 Ile His Asn Val Leu Phe Thr Asp Gly Lys Glu Thr Gly Glu Thr Phe
             420                 425                 430        
 Thr Phe Lys Arg His Ser Gln Asp Ala Ser Gln Asp Val Lys Leu Tyr
         435                 440                 445            
 Ser Asp Thr Ala Pro Thr Glu Asp Leu Ile Glu Glu Val Thr Ala Asp
     450                 455                 460                
 His Pro Glu Val Val Thr Met Ile Glu Glu Thr Ile Lys Met Ser Gln
 465                 470                 475                 480
 Asp Ile Asn Phe Glu Gln Pro Tyr Glu Lys His Ala Glu Ile Leu Gln
                 485                 490                 495    
 Glu Val Leu Gly Glu Lys Tyr Tyr Glu Tyr Leu Leu Ser Ala Leu Tyr
             500                 505                 510        
 His Val Arg Tyr Gln Glu Ser Glu Asp Glu Leu Asn Thr Ala Leu Ser
         515                 520                 525            
 Phe Lys Glu Leu Ser Val Arg Val Tyr Ser Gly Ala Tyr Lys Ser Thr
     530                 535                 540                
 Arg Asn Pro Thr Leu Leu Ile
 545                 550    



      <210> 1493
      <211> 473
      <212> PRT
      <213> Homo sapiens


      <400> 1493
 Met Pro Ala Met Arg Ser Cys Thr Arg Arg Thr Leu Glu Phe Ser Leu
   1               5                  10                  15    
 Ala Ala Ser Leu Cys Ala Thr Pro Tyr Cys Phe Leu Leu Ser Gln Met
              20                  25                  30        
 Gln Met Arg Phe Asp Gly Arg Leu Gly Phe Pro Gly Gly Phe Val Asp
          35                  40                  45            
 Ser Gln Asp Ser Ser Leu Glu Asp Gly Leu Asn Arg Gly Leu Leu Glu
      50                  55                  60                
 Leu Leu Gly Glu Ala Ala Ala Ala Phe Arg Val Glu Arg Pro Asp Tyr
  65                  70                  75                  80
 Arg Ser Ser His Ala Gly Ser Arg Pro Arg Val Val Ala His Phe Tyr
                  85                  90                  95    
 Ala Lys Ser Leu Thr Leu Glu Gln Leu Leu Ala Val Glu Ala Ser Ala
             100                 105                 110        
 Thr Gly Ala Lys Asp His Gly Leu Glu Arg Val Glu Pro Thr Gly Pro
         115                 120                 125            
 Pro Leu Asp Arg Ser Leu Gly Leu Val Ser Ala Gly Val Leu Arg Val
     130                 135                 140                
 Val Ala Ser Ala Leu Glu Arg Ser Ala Lys Glu Arg Met Glu Val Ser
 145                 150                 155                 160
 Glu Lys Arg Asn Gln Trp Val Tyr Asn Ile Leu Leu Ser Ser Ile Leu
                 165                 170                 175    
 Leu Leu Gln His Pro Val Ile Pro Gly Cys Gly Cys Arg Glu Lys Pro
             180                 185                 190        
 Gly Thr Ile Met Asn Leu Glu Gln Leu Phe Arg Tyr Met Ala Gln Pro
         195                 200                 205            
 Ser Thr Cys Ser Leu Glu Ser Trp Ala Phe Cys Leu Arg Ile Val Glu
     210                 215                 220                
 Trp Gly Met Val Gly Gly Gly Gly Ala Glu Ala Glu Lys Asp Leu Lys
 225                 230                 235                 240
 Gly Asp Gly Lys Gly Leu Gly Leu Ala Ala Pro Pro Arg Leu Gly Leu
                 245                 250                 255    
 Val Arg Gly Glu Thr Arg Pro Ser Ala His Trp Ala Phe Gly Thr Ala
             260                 265                 270        
 Glu Glu Gln Cys Pro Ala Met Ala Gly Ala Arg Arg Leu Glu Leu Gly
         275                 280                 285            
 Glu Ala Leu Ala Leu Gly Ser Gly Trp Arg His Ala Cys His Ala Leu
     290                 295                 300                
 Leu Tyr Ala Pro Asp Pro Gly Met Leu Phe Gly Arg Ile Pro Leu Arg
 305                 310                 315                 320
 Tyr Ala Ile Leu Met Gln Met Arg Phe Asp Gly Arg Leu Gly Phe Pro
                 325                 330                 335    
 Gly Gly Phe Val Asp Thr Gln Asp Arg Ser Leu Glu Asp Gly Leu Asn
             340                 345                 350        
 Arg Glu Leu Arg Glu Glu Leu Gly Glu Ala Ala Ala Ala Phe Arg Val
         355                 360                 365            
 Glu Arg Thr Asp Tyr Arg Ser Ser His Val Gly Ser Gly Pro Arg Val
     370                 375                 380                
 Val Ala His Phe Tyr Ala Lys Arg Leu Thr Leu Glu Glu Leu Leu Ala
 385                 390                 395                 400
 Val Glu Ala Gly Ala Thr Arg Ala Lys Asp His Gly Leu Glu Val Leu
                 405                 410                 415    
 Gly Leu Val Arg Val Pro Leu Tyr Thr Leu Arg Asp Gly Val Gly Gly
             420                 425                 430        
 Leu Pro Thr Phe Leu Glu Asn Ser Phe Ile Gly Ser Ala Arg Glu Gln
         435                 440                 445            
 Leu Leu Glu Ala Leu Gln Asp Leu Gly Leu Leu Gln Ser Gly Ser Ile
     450                 455                 460                
 Ser Gly Leu Lys Ile Pro Ala His His
 465                 470            



      <210> 1494
      <211> 173
      <212> PRT
      <213> Homo sapiens


      <400> 1494
 Met Arg Phe Phe Thr Ser Val Ala Cys Tyr Gly Ser Cys Leu Phe Ala
   1               5                  10                  15    
 Ser Glu Leu Leu Ile Arg Cys Lys Asp Trp Leu Lys Gly Arg Pro Ala
              20                  25                  30        
 Leu Phe Thr Ala Leu Leu Ala Cys Val Leu Tyr Leu Cys Glu Trp Thr
          35                  40                  45            
 Gly Ala Lys His Val Pro Gly Ser Ser Cys Glu Ser Glu Cys Ser Ile
      50                  55                  60                
 Glu Pro Lys Asn Thr Asp Val Glu Met Leu Gln Ala Ser Thr Ser Asn
  65                  70                  75                  80
 Pro Ile Pro Gly Asp Gly Phe Ser Arg Ala Thr Lys Asp Ser Met Ile
                  85                  90                  95    
 Arg Lys Phe Leu Glu Gly Asn Ser Met Gly Met Thr Asn Leu Glu Arg
             100                 105                 110        
 Asp Gln Cys His Leu Gly Gln Glu Glu Asp Val Tyr His Thr Val Asp
         115                 120                 125            
 Asp Asp Glu Ala Phe Ser Val Asp Leu Ala Ser Arg Pro Pro Val Pro
     130                 135                 140                
 Val Pro Arg Pro Glu Thr Thr Ala Pro Gly Ala His Gln Leu Pro Asp
 145                 150                 155                 160
 Asn Glu Pro Tyr Ile Phe Lys Gly Lys Tyr Gly Arg Glu
                 165                 170            



      <210> 1495
      <211> 124
      <212> PRT
      <213> Homo sapiens


      <400> 1495
 Met Val Thr Gly Phe Trp Gly Val Pro Ala Lys Gly Ser Leu His Phe
   1               5                  10                  15    
 Ile Ala Val Glu Trp Val Leu Val Leu Leu Lys Ile Val Gln Glu Ser
              20                  25                  30        
 Arg Phe Ala Ser Ser Glu Pro Pro Leu Gln Trp Met Thr Pro Phe Arg
          35                  40                  45            
 Gly Met Glu Phe Glu Gly Ala Ile Ile Ala Leu Phe His Leu Leu Ala
      50                  55                  60                
 Thr Arg Thr Asp Lys Val Arg Ala Leu Arg Glu Ala Phe Tyr Arg Gln
  65                  70                  75                  80
 Asn Leu Pro Asn Leu Met Asn Leu Ile Ala Thr Ile Phe Val Phe Ala
                  85                  90                  95    
 Val Val Ile Tyr Phe Gln Val Cys Pro Asp Pro Thr Pro Gly Ser Phe
             100                 105                 110        
 His Gly Ser Val Gly Cys Thr Val Ile Ile Leu Cys
         115                 120                



      <210> 1496
      <211> 2043
      <212> PRT
      <213> Homo sapiens


      <400> 1496
 Met Ala Ala Arg Gly Arg Gly Leu Leu Leu Leu Thr Leu Ser Val Leu
   1               5                  10                  15    
 Leu Ala Ala Gly Pro Ser Ala Ala Ala Ala Lys Leu Asn Ile Pro Lys
              20                  25                  30        
 Val Leu Leu Pro Phe Thr Arg Ala Thr Arg Val Asn Phe Thr Leu Glu
          35                  40                  45            
 Ala Ser Glu Gly Cys Tyr Arg Trp Leu Ser Thr Arg Pro Glu Val Ala
      50                  55                  60                
 Ser Ile Glu Pro Leu Gly Leu Asp Glu Gln Gln Cys Ser Gln Lys Ala
  65                  70                  75                  80
 Val Val Gln Ala Arg Leu Thr Gln Pro Ala Arg Leu Thr Ser Ile Ile
                  85                  90                  95    
 Phe Ala Glu Asp Ile Thr Thr Gly Gln Val Leu Arg Cys Asp Ala Ile
             100                 105                 110        
 Val Asp Leu Ile His Asp Ile Gln Ile Val Ser Thr Thr Arg Glu Leu
         115                 120                 125            
 Tyr Leu Glu Asp Ser Pro Leu Glu Leu Lys Ile Gln Ala Leu Asp Ser
     130                 135                 140                
 Glu Gly Asn Thr Phe Ser Thr Leu Ala Gly Leu Val Phe Glu Trp Thr
 145                 150                 155                 160
 Ile Val Lys Asp Ser Glu Ala Asp Arg Phe Ser Asp Ser His Asn Ala
                 165                 170                 175    
 Leu Arg Ile Leu Thr Phe Leu Glu Ser Thr Tyr Ile Pro Pro Ser Tyr
             180                 185                 190        
 Ile Ser Glu Met Glu Lys Ala Ala Lys Gln Gly Asp Thr Ile Leu Val
         195                 200                 205            
 Ser Gly Met Lys Thr Gly Ser Ser Lys Leu Lys Ala Arg Ile Gln Glu
     210                 215                 220                
 Ala Val Tyr Lys Asn Val Arg Pro Ala Glu Val Arg Leu Leu Ile Leu
 225                 230                 235                 240
 Glu Asn Ile Leu Leu Asn Pro Ala Tyr Asp Val Tyr Leu Met Val Gly
                 245                 250                 255    
 Thr Ser Ile His Tyr Lys Val Gln Lys Ile Arg Gln Gly Lys Ile Thr
             260                 265                 270        
 Gly Ile Arg Met Gln Gly Ala Ser Arg Leu Pro Asn Ser Thr Ile Tyr
         275                 280                 285            
 Val Val Glu Pro Gly Tyr Leu Gly Phe Thr Val His Pro Gly Asp Arg
     290                 295                 300                
 Trp Val Leu Glu Thr Gly Arg Leu Tyr Glu Ile Thr Ile Glu Val Phe
 305                 310                 315                 320
 Asp Lys Phe Ser Asn Lys Val Tyr Val Ser Asp Asn Ile Arg Ile Glu
                 325                 330                 335    
 Thr Val Leu Pro Ala Glu Phe Phe Glu Val Leu Ser Ser Ser Gln Asn
             340                 345                 350        
 Gly Ser Tyr His Arg Ile Arg Ala Leu Lys Arg Gly Gln Thr Ala Ile
         355                 360                 365            
 Asp Ala Ala Leu Thr Ser Val Val Asp Gln Ala Ile Phe Lys Lys Pro
     370                 375                 380                
 Ile Ser Leu Arg Glu Gln Ser Phe Ala Asp Trp Lys Ile Gly Leu Gly
 385                 390                 395                 400
 Val Pro Ile Phe Leu Pro Arg Thr Glu Gly Leu Leu Ala Trp Lys Gly
                 405                 410                 415    
 Gln Gln Ala Asp Gly Gly Val His Ile Leu Gln Val Pro Val Trp Asn
             420                 425                 430        
 Gln Gln Glu Val Glu Ile His Ile Pro Ile Thr Leu Tyr Pro Ser Ile
         435                 440                 445            
 Leu Thr Phe Pro Trp Gln Pro Lys Thr Gly Ala Tyr Gln Tyr Thr Ile
     450                 455                 460                
 Arg Ala His Gly Gly Ser Gly Asn Phe Ser Trp Ser Ser Ser Ser His
 465                 470                 475                 480
 Leu Val Ala Thr Val Thr Val Lys Gly Val Met Thr Thr Gly Ser Asp
                 485                 490                 495    
 Ile Gly Phe Ser Val Ile Gln Ala His Asp Val Gln Asn Pro Leu His
             500                 505                 510        
 Phe Gly Glu Met Lys Val Tyr Val Ile Glu Pro His Ser Met Glu Phe
         515                 520                 525            
 Ala Pro Cys Gln Val Glu Ala Arg Val Gly Gln Ala Leu Glu Leu Pro
     530                 535                 540                
 Leu Arg Ile Ser Gly Leu Met Pro Gly Gly Ala Ser Glu Val Val Thr
 545                 550                 555                 560
 Leu Ser Asp Cys Ser His Phe Asp Leu Ala Val Glu Val Glu Asn Gln
                 565                 570                 575    
 Gly Val Phe Gln Pro Leu Pro Gly Trp Leu Arg Ser Lys Gln Gln Lys
             580                 585                 590        
 Thr Ala Asn Val Asp Lys Asp Val Lys Thr Leu Glu Leu Leu Cys Ala
         595                 600                 605            
 Ala Gly Val Tyr Val Lys Gly Ala Ala Ala Val Glu Ser Arg Arg Leu
     610                 615                 620                
 Pro Pro Gly Ser Glu His Cys Ser Gly Ile Arg Val Lys Ala Glu Ala
 625                 630                 635                 640
 Gln Gly Ser Thr Thr Leu Leu Val Ser Tyr Arg His Gly His Val His
                 645                 650                 655    
 Leu Ser Ala Lys Ile Thr Ile Ala Ala Tyr Leu Pro Leu Lys Ile Met
             660                 665                 670        
 Pro Gln Thr Glu Lys Glu Thr Asp Thr Pro Tyr Pro Pro Gln Ala Tyr
         675                 680                 685            
 Ser Met Ile Arg Glu Thr Ser Gln Ala Met Lys Leu Leu Gln Gly Glu
     690                 695                 700                
 Glu His Gln Ala Val Asp Pro Ser Ser Val Ala Leu Val Thr Leu Gly
 705                 710                 715                 720
 Ser Ser Lys Glu Met Leu Phe Glu Gly Gly Pro Arg Pro Trp Ile Leu
                 725                 730                 735    
 Glu Pro Ser Lys Phe Phe Gln Asn Val Thr Ala Glu Asp Thr Asp Ser
             740                 745                 750        
 Ile Gly Leu Ala Leu Phe Ala Pro His Ser Ser Arg Asn Tyr Gln Gln
         755                 760                 765            
 His Trp Ile Leu Val Thr Cys Gln Ala Leu Gly Glu Gln Val Ile Ala
     770                 775                 780                
 Leu Ser Val Gly Asn Lys Pro Ser Leu Thr Asn Pro Phe Pro Ala Val
 785                 790                 795                 800
 Glu Pro Ala Val Val Lys Phe Val Cys Ala Pro Pro Ser Arg Leu Thr
                 805                 810                 815    
 Leu Ala Pro Val Tyr Thr Ser Pro Gln Leu Asp Met Ser Cys Pro Leu
             820                 825                 830        
 Leu Gln Gln Asn Lys Gln Val Val Ser Val Gly Tyr Ala Arg Glu Glu
         835                 840                 845            
 Glu Asp Ile Gly Gly Leu Ala His Gly Pro Glu His Cys Asn Gly His
     850                 855                 860                
 Ser Ser Thr Leu His Phe Leu Arg Leu Asn Asn Trp Pro Cys Glu Asp
 865                 870                 875                 880
 Ala Gly Phe Ile Cys Val Leu Tyr Ala Gly Asp Thr Gln Leu Gly Glu
                 885                 890                 895    
 Val Pro Val Ser Ser His Arg Asn Pro Arg Leu Asp Leu Ala Ala Tyr
             900                 905                 910        
 Asp Gln Glu Gly Arg Arg Phe Asp Asn Phe Ser Ser Leu Ser Ile Gln
         915                 920                 925            
 Trp Glu Ser Thr Arg Pro Val Leu Ala Ser Ile Glu Pro Glu Leu Pro
     930                 935                 940                
 Met Gln Leu Val Ser Gln Asp Asp Glu Ser Gly Gln Lys Lys Leu His
 945                 950                 955                 960
 Gly Glu Leu Gly Thr Ser Leu Met Ala Gln Ala Gly Glu Gln Arg Pro
                 965                 970                 975    
 Asp Arg Lys Pro Ala Lys His Asp Pro Leu Val Pro Leu Ser Ala Ser
             980                 985                 990        
 Ile Glu Leu Ile Leu Val Glu Asp Val Arg Val Ser Pro Glu Glu Val
         995                1000                1005            
 Thr Ile Tyr Asn His Pro Gly Ile Gln Ala Glu Leu Arg Ile Arg Glu
    1010                1015                1020                
 Gly Ser Gly Tyr Phe Phe Leu Asn Thr Ser Thr Ala Asp Val Val Lys
1025                1030                1035                1040
 Val Ala Tyr Gln Glu Ala Arg Gly Val Ala Met Val His Pro Leu Leu
                1045                1050                1055    
 Pro Gly Ser Ser Thr Ile Met Ile His Asp Leu Cys Leu Val Phe Pro
            1060                1065                1070        
 Ala Pro Ala Lys Ala Val Val Tyr Val Ser Asp Ile Gln Glu Leu Tyr
        1075                1080                1085            
 Ile Arg Val Val Asp Lys Val Glu Ile Gly Lys Thr Val Lys Ala Tyr
    1090                1095                1100                
 Val Arg Val Leu Asp Leu His Lys Lys Pro Phe Leu Ala Lys Tyr Phe
1105                1110                1115                1120
 Pro Phe Met Asp Leu Lys Leu Arg Ala Ala Ser Pro Ile Ile Thr Leu
                1125                1130                1135    
 Val Ala Leu Asp Glu Ala Leu Asp Asn Tyr Thr Ile Thr Phe Leu Ile
            1140                1145                1150        
 Arg Gly Val Ala Ile Gly Gln Thr Ser Leu Thr Ala Ser Val Thr Asn
        1155                1160                1165            
 Lys Ala Gly Gln Arg Ile Asn Ser Ala Pro Gln Gln Ile Glu Val Phe
    1170                1175                1180                
 Pro Pro Phe Arg Leu Met Pro Arg Lys Val Thr Leu Leu Ile Gly Ala
1185                1190                1195                1200
 Thr Met Gln Val Thr Ser Glu Gly Gly Pro Gln Pro Gln Ser Asn Ile
                1205                1210                1215    
 Leu Phe Ser Ile Ser Asn Glu Ser Val Ala Leu Val Ser Ala Ala Gly
            1220                1225                1230        
 Leu Val Gln Gly Leu Ala Ile Gly Asn Gly Thr Val Ser Gly Leu Val
        1235                1240                1245            
 Gln Ala Val Asp Ala Glu Thr Gly Lys Val Val Ile Ile Ser Gln Asp
    1250                1255                1260                
 Leu Val Gln Val Glu Val Leu Leu Leu Arg Ala Val Arg Ile Arg Ala
1265                1270                1275                1280
 Pro Ile Met Arg Met Arg Thr Gly Thr Gln Met Pro Ile Tyr Val Thr
                1285                1290                1295    
 Gly Ile Thr Asn His Gln Asn Pro Phe Ser Phe Gly Asn Ala Val Pro
            1300                1305                1310        
 Gly Leu Thr Phe His Trp Ser Val Thr Lys Arg Asp Val Leu Asp Leu
        1315                1320                1325            
 Arg Gly Arg His His Glu Tyr Asn Phe Ala Met Asn Val Leu Gly Arg
    1330                1335                1340                
 Val Lys Gly Arg Thr Gly Leu Arg Val Val Val Lys Ala Val Asp Pro
1345                1350                1355                1360
 Thr Ser Gly Gln Leu Tyr Gly Leu Ala Arg Glu Leu Ser Asp Glu Ile
                1365                1370                1375    
 Gln Val Gln Val Phe Glu Lys Leu Gln Leu Leu Asn Pro Glu Ile Glu
            1380                1385                1390        
 Ala Glu Gln Ile Leu Met Ser Pro Asn Ser Tyr Ile Lys Leu Gln Thr
        1395                1400                1405            
 Asn Arg Asp Gly Ala Ala Ser Leu Ser Tyr Arg Val Leu Asp Gly Pro
    1410                1415                1420                
 Glu Lys Val Pro Val Val His Val Asp Glu Lys Gly Phe Leu Ala Ser
1425                1430                1435                1440
 Gly Ser Met Ile Gly Thr Ser Thr Ile Glu Val Ile Ala Gln Glu Pro
                1445                1450                1455    
 Phe Gly Ala Asn Gln Thr Ile Ile Val Ala Val Lys Val Ser Pro Val
            1460                1465                1470        
 Ser Tyr Leu Arg Val Ser Met Ser Pro Val Leu His Thr Gln Asn Lys
        1475                1480                1485            
 Glu Ala Leu Val Ala Val Pro Leu Gly Met Thr Val Thr Phe Thr Val
    1490                1495                1500                
 His Phe His Asp Asn Ser Gly Asp Val Phe His Ala His Ser Ser Val
1505                1510                1515                1520
 Leu Asn Phe Ala Thr Asn Arg Asp Asp Phe Val Gln Ile Gly Lys Gly
                1525                1530                1535    
 Pro Thr Asn Asn Thr Cys Val Val Arg Thr Val Ser Val Gly Leu Thr
            1540                1545                1550        
 Leu Leu Arg Val Trp Asp Ala Glu His Pro Gly Leu Ser Asp Phe Met
        1555                1560                1565            
 Pro Leu Pro Val Leu Gln Ala Ile Ser Pro Glu Leu Ser Gly Ala Met
    1570                1575                1580                
 Val Val Gly Asp Val Leu Cys Leu Ala Thr Val Leu Thr Ser Leu Glu
1585                1590                1595                1600
 Gly Leu Ser Gly Thr Trp Ser Ser Ser Ala Asn Ser Ile Leu His Ile
                1605                1610                1615    
 Asp Pro Lys Thr Gly Val Ala Val Ala Arg Ala Val Gly Ser Val Thr
            1620                1625                1630        
 Val Tyr Tyr Glu Val Ala Gly His Leu Arg Thr Tyr Lys Glu Val Val
        1635                1640                1645            
 Val Ser Val Pro Gln Arg Ile Met Ala Arg His Leu His Pro Ile Gln
    1650                1655                1660                
 Thr Ser Phe Gln Glu Ala Thr Ala Ser Lys Val Ile Val Ala Val Gly
1665                1670                1675                1680
 Asp Arg Ser Ser Asn Leu Arg Gly Glu Cys Thr Pro Thr Gln Arg Glu
                1685                1690                1695    
 Val Ile Gln Ala Leu His Pro Glu Thr Leu Ile Ser Cys Gln Ser Gln
            1700                1705                1710        
 Phe Lys Pro Ala Val Phe Asp Phe Pro Ser Gln Asp Val Phe Thr Val
        1715                1720                1725            
 Glu Pro Gln Phe Asp Thr Ala Leu Gly Gln Tyr Phe Cys Ser Ile Thr
    1730                1735                1740                
 Met His Arg Leu Thr Asp Lys Gln Arg Lys His Leu Ser Met Lys Lys
1745                1750                1755                1760
 Thr Ala Leu Val Val Ser Ala Ser Leu Ser Ser Ser His Phe Ser Thr
                1765                1770                1775    
 Glu Gln Val Gly Ala Glu Val Pro Phe Ser Pro Gly Leu Phe Ala Asp
            1780                1785                1790        
 Gln Ala Glu Ile Leu Leu Ser Asn His Tyr Thr Ser Ser Glu Ile Arg
        1795                1800                1805            
 Val Phe Gly Ala Pro Glu Val Leu Glu Asn Leu Glu Val Lys Ser Gly
    1810                1815                1820                
 Ser Pro Ala Val Leu Ala Phe Ala Lys Glu Lys Ser Phe Gly Trp Pro
1825                1830                1835                1840
 Ser Phe Ile Thr Tyr Thr Val Gly Val Leu Asp Pro Ala Ala Gly Ser
                1845                1850                1855    
 Gln Gly Pro Leu Ser Thr Thr Leu Thr Phe Ser Ser Pro Val Thr Asn
            1860                1865                1870        
 Gln Ala Ile Ala Ile Pro Val Thr Val Ala Phe Val Val Asp Arg Arg
        1875                1880                1885            
 Gly Pro Gly Pro Tyr Gly Ala Ser Leu Phe Gln His Phe Leu Asp Ser
    1890                1895                1900                
 Tyr Gln Val Met Phe Phe Thr Leu Phe Ala Leu Leu Ala Gly Thr Ala
1905                1910                1915                1920
 Val Met Ile Ile Gly Glu Glu Ala Ala Cys Ile Ser Gly Ser Val Pro
                1925                1930                1935    
 Leu Pro Arg Pro Ala Leu Thr Asn Pro Val Leu Leu Gln Pro Thr Thr
            1940                1945                1950        
 Leu Ser Ala Arg Pro Gly Ile Leu Leu Cys Leu Gln Pro Ser Arg Leu
        1955                1960                1965            
 Glu Pro Ala Leu Asp Thr Ala Pro Thr Lys Leu Asp Phe Ile Lys Ser
    1970                1975                1980                
 Leu Ser Glu Thr Leu Cys Leu Leu Ile Val Asp Asn His Gly Asp His
1985                1990                1995                2000
 Lys Gly Thr Gln Thr Arg Leu Pro Met Val Ile Trp Asn Ala Val Gly
                2005                2010                2015    
 Met Gln His Pro Gly Thr Ser Thr Gly Pro Val Ser Val Ser Ala Ser
            2020                2025                2030        
 Ala Met Val Ala Asp Asn Trp Met Ser Leu Ser
        2035                2040            



      <210> 1497
      <211> 125
      <212> PRT
      <213> Homo sapiens


      <400> 1497
 Met Asp Met Arg Val Leu Ala Gln Leu Leu Gly Leu Leu Leu Leu Cys
   1               5                  10                  15    
 Phe Pro Gly Ala Arg Cys Asp Ile Gln Met Thr Gln Ser Pro Ser Ser
              20                  25                  30        
 Leu Ser Ala Ser Val Gly Asp Arg Val Thr Ile Thr Cys Arg Ala Ser
          35                  40                  45            
 Gln Gly Ile Ser Ser Trp Leu Ala Trp Tyr Gln Gln Lys Pro Glu Lys
      50                  55                  60                
 Ala Pro Lys Ser Leu Ile Tyr Ala Ala Ser Ser Leu Gln Ser Gly Val
  65                  70                  75                  80
 Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr
                  85                  90                  95    
 Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln
             100                 105                 110        
 Tyr Asn Ser Tyr Pro Pro Thr Val Leu His Thr Gln Thr
         115                 120                 125



      <210> 1498
      <211> 372
      <212> PRT
      <213> Homo sapiens


      <400> 1498
 Met Leu Phe Thr Val Pro Ala Val Pro Thr Cys Leu Ala Leu Val Trp
   1               5                  10                  15    
 Ala Gly Met Ser Gly Ile Gly Met Phe Ser His Arg Ser Phe Ser Gly
              20                  25                  30        
 His Gly Pro Ser Trp Asp Leu Gly Leu Leu Leu Gly Tyr Gln Pro Ala
          35                  40                  45            
 Ser Leu Lys Pro Leu Pro Lys Cys His Trp Gly Pro Val Thr Ile Glu
      50                  55                  60                
 Glu Ala Ser Val Gly His Thr Val Arg Ser Thr Ala Lys Thr Asn Asn
  65                  70                  75                  80
 Ala Leu Thr Ser Phe Tyr Met Asn Pro His Leu Pro Asn Ile Tyr Phe
                  85                  90                  95    
 Gly Met Leu Arg Ser Leu Arg Ser Gln Lys Ser Arg Asp Thr Gly Val
             100                 105                 110        
 Arg Met Pro Leu Gln Thr Thr Val Cys Gly Ala Glu Met Ser Glu Leu
         115                 120                 125            
 Glu Gln Arg Arg Gly Ala Arg Arg Leu Lys Phe Ser Leu Pro His Phe
     130                 135                 140                
 Ser Gly Arg Cys His Glu Ala Asp Pro Pro Glu Gln Phe Val Leu Ser
 145                 150                 155                 160
 Ser Phe His Trp Phe Ser Ser Ser Leu Pro Gly Leu Glu Asn Met Val
                 165                 170                 175    
 Glu Ala Lys Gly Leu Gln Gln Ser Trp Ala Pro Thr Ile Gly Asn Glu
             180                 185                 190        
 Asp Thr Met Lys Lys Val Ser Pro Ala Asn His Arg Ile Pro Leu Ser
         195                 200                 205            
 Asp Gly Asn Ser Ile Pro Ile Ile Arg Leu Gly Thr Tyr Ser Glu Pro
     210                 215                 220                
 Lys Leu Thr Pro Lys Gly Ala Asn Asp Leu Leu Lys Ala Thr Gln Gln
 225                 230                 235                 240
 Val Gly Ala Gly Gln Leu Glu Leu Ile Gln Asn Asn Pro Gly Leu Lys
                 245                 250                 255    
 Pro Lys Pro Val Ser Asn Glu Val Glu Cys His Pro Tyr Tyr Thr Gln
             260                 265                 270        
 Pro Lys Leu Leu Lys Phe Arg Gln Gln His Asp Ile Val Met Ile Ala
         275                 280                 285            
 Tyr Ser Pro Leu Gly Thr Thr Arg Asn Pro Thr Trp Thr Asn Met Ser
     290                 295                 300                
 Ser Leu Pro Ser Leu Lys Asp Ala Leu Leu Lys Arg Cys Asn Lys Ile
 305                 310                 315                 320
 Thr Ala Gln Val Ile Leu Arg Phe Asn Ile Gln Gln Gly Val Val Val
                 325                 330                 335    
 Ile Pro Lys Ser Phe Asn Pro Glu Lys Ile Lys Glu Asn Leu Gln Ala
             340                 345                 350        
 Phe Asp Phe Ser Leu Thr Glu Ser Arg Thr Leu Lys Pro Gly Val Lys
         355                 360                 365            
 Met Ser Ala Ser
     370        



      <210> 1499
      <211> 626
      <212> PRT
      <213> Homo sapiens


      <400> 1499
 Met Leu Glu Asp Cys Gln Val Ser Leu Trp Val Arg Leu Thr Trp Cys
   1               5                  10                  15    
 Gln Leu Ala Ser Leu Thr Arg Ala Leu Arg Thr Ser Ala Ile Ser Glu
              20                  25                  30        
 Ala Ala Leu Leu Glu Met Thr Arg Trp Lys Thr Arg Ala Thr Glu Lys
          35                  40                  45            
 Leu Ile Thr Trp Pro Gln Ile Pro Glu Gln Gly Ala Val Lys Gly Ser
      50                  55                  60                
 Thr Ile Thr Pro Leu Ser Ser Phe Pro Thr Val Gln Gly Ala Trp Val
  65                  70                  75                  80
 Leu Ser Gln Gln Val Gly Ile Met Gly Ala Thr Ile Gln Asp Glu Ile
                  85                  90                  95    
 Trp Val Gly Thr Gln Asn Arg Thr Leu Leu Thr Ser Val Met Arg Thr
             100                 105                 110        
 Gly Arg Gly Ala Arg Gly Cys Leu Phe Ser Leu Ser Leu Ser Leu Cys
         115                 120                 125            
 Met His Arg Glu Glu Ala Lys Gln Ala Gln Ser Glu Lys Ala Leu Ser
     130                 135                 140                
 Ile Ser Arg Lys Arg Gly Leu Ser Arg Asn Gly Cys Ser Lys Cys Leu
 145                 150                 155                 160
 Asn Ser Asn Val Ile Ile Ser Gln Thr Thr Thr Ser Lys His Gln Ala
                 165                 170                 175    
 Asp Pro Val Asn Pro Thr Asp Gly Val Arg Gly Leu Leu Pro Lys Glu
             180                 185                 190        
 Ala Gly Gly Thr His Glu Lys Ser His Asp Ala Glu Phe Asp Ser His
         195                 200                 205            
 Leu Gln Thr Ile Lys His Gly Arg Met Ser Leu Cys Gly Pro Val Cys
     210                 215                 220                
 Thr Ala Leu Val Thr Gly Lys Asp Asn Glu Val Ser Asn Tyr Pro Thr
 225                 230                 235                 240
 Asp Met Asn Ala Asp His Tyr Ile Cys Thr Leu Ile Thr Gly Lys Val
                 245                 250                 255    
 Ile Val Tyr Ser Ser Asp Lys Trp Leu Phe Tyr Ser Val Cys Lys Gly
             260                 265                 270        
 Leu Ser Val Tyr Pro Pro Gly Phe Ser Arg His Leu Ile Thr Leu Leu
         275                 280                 285            
 Gly Thr Trp Met Pro Ser Leu Glu Val Asp Pro Asn Cys Phe Cys Pro
     290                 295                 300                
 Thr His Ser Gln Ser Leu Gln Ala Val Leu Val His Phe His Thr Ala
 305                 310                 315                 320
 Asp Lys Asp Ile Pro Glu Thr Gly Gln Phe Thr Lys Glu Arg Gly Leu
                 325                 330                 335    
 Ile Gly Leu Thr Val Pro Tyr Gly Trp Gly Asn Leu Thr Ile Met Val
             340                 345                 350        
 Glu Gly Lys Glu Glu Gln Val Pro Phe Tyr Met Asp Gly Ser Arg Gln
         355                 360                 365            
 Arg Glu Asn Glu Glu Asp Ala Lys Ala Glu Thr His Asp Gln Thr Ile
     370                 375                 380                
 Arg Pro Arg Glu Ile His Ser Leu Pro Gly Glu Gln Tyr Gly Gly Asn
 385                 390                 395                 400
 Arg Pro His Asp Ser Ile Ser Ser His Gln Val Leu Pro Thr Thr His
                 405                 410                 415    
 Trp Asn His Gly Ser Thr Val Gln Asp Glu Ile Trp Val Gly Thr Gln
             420                 425                 430        
 Pro Asn Pro Ile Thr Gly Ser Val Gly Ser Val Ser Ser Met Phe Leu
         435                 440                 445            
 Gly Phe Val Pro Phe Ser His Leu His Glu Asn Ser Leu Ser His Pro
     450                 455                 460                
 Thr Phe Cys Arg Pro Thr Gln Thr Ala Trp Ser Leu Trp Gly Leu His
 465                 470                 475                 480
 Thr Leu Ser Pro Gln Tyr Ser Pro Gly Asn Leu Thr Cys Asn Cys Lys
                 485                 490                 495    
 Gln Gly Thr Ser Pro Thr Gly Arg Gln Trp Asp Ile Cys Val Ser Ile
             500                 505                 510        
 Ala Thr Ala Arg Arg Ile Leu Lys Thr Glu Pro Gly Thr Glu Asp Ala
         515                 520                 525            
 Trp Glu Gly Pro Val Glu Met Gly Leu Glu Thr Gly Leu Gly Lys Lys
     530                 535                 540                
 Ala Arg Pro His Leu Gln Glu Glu Asp Glu Arg Glu Gln Glu Lys Lys
 545                 550                 555                 560
 Arg Lys Lys Lys Lys Lys Lys Lys Lys Lys Lys Lys Lys Lys Lys Lys
                 565                 570                 575    
 Lys Lys Lys Lys Lys Lys Lys Gln Gln Glu Lys Glu Lys Glu Lys Glu
             580                 585                 590        
 Lys Glu Lys Glu Lys Glu Lys Gly Arg Lys Gly Lys Gly Arg Gly Lys
         595                 600                 605            
 Glu Glu Glu Lys Lys Lys Lys Glu Lys Lys Thr Glu Glu Glu Glu Lys
     610                 615                 620                
 Lys Lys
 625    



      <210> 1500
      <211> 838
      <212> PRT
      <213> Homo sapiens


      <400> 1500
 Met Gly Pro Phe Leu Leu Asn Ala Val Arg Trp Leu Ala Arg Gly Gln
   1               5                  10                  15    
 Thr Gly Lys Val Gly Val Asn Thr Asn Leu Lys Asp Leu Cys Pro Leu
              20                  25                  30        
 Leu Ser Glu His Gly Leu Gln Cys Ser Leu Glu Pro His Leu Asn Ser
          35                  40                  45            
 Asp Leu Cys Val Tyr Cys Cys Lys Ala Tyr Ser Asp Lys Glu Ala Lys
      50                  55                  60                
 Gln Leu Gln Glu Phe Val Ala Glu Gly Gly Gly Leu Leu Ile Gly Gly
  65                  70                  75                  80
 Gln Ala Trp Trp Trp Ala Ser Gln Asn Pro Gly His Cys Pro Leu Ala
                  85                  90                  95    
 Gly Phe Pro Gly Asn Ile Ile Leu Asn Cys Phe Gly Leu Ser Ile Leu
             100                 105                 110        
 Pro Gln Thr Leu Lys Ala Gly Cys Phe Pro Val Pro Thr Pro Glu Met
         115                 120                 125            
 Arg Ser Tyr His Phe Arg Lys Ala Leu Ser Gln Phe Gln Ala Ile Leu
     130                 135                 140                
 Asn His Glu Asn Gly Asn Leu Glu Lys Ser Cys Leu Ala Lys Leu Arg
 145                 150                 155                 160
 Val Asp Gly Ala Ala Phe Leu Gln Ile Pro Ala Glu Gly Val Pro Ala
                 165                 170                 175    
 Tyr Ile Ser Leu His Arg Leu Leu Arg Lys Met Leu Arg Gly Ser Gly
             180                 185                 190        
 Leu Pro Ala Val Ser Arg Glu Asn Pro Val Ala Ser Asp Ser Tyr Glu
         195                 200                 205            
 Ala Ala Val Leu Ser Leu Ala Thr Gly Leu Ala His Ser Gly Thr Asp
     210                 215                 220                
 Cys Ser Gln Leu Ala Gln Gly Leu Gly Thr Trp Thr Cys Ser Ser Ser
 225                 230                 235                 240
 Leu Tyr Pro Ser Lys His Pro Ile Thr Val Glu Ile Asn Gly Ile Asn
                 245                 250                 255    
 Pro Gly Asn Asn Asp Cys Trp Val Ser Thr Gly Leu Tyr Leu Leu Glu
             260                 265                 270        
 Gly Gln Asn Ala Glu Val Ser Leu Ser Glu Ala Ala Ala Ser Ala Gly
         275                 280                 285            
 Leu Arg Val Gln Ile Gly Cys His Thr Asp Asp Leu Thr Lys Ala Arg
     290                 295                 300                
 Lys Leu Ser Arg Ala Pro Val Val Thr His Gln Cys Trp Met Asp Arg
 305                 310                 315                 320
 Thr Glu Arg Ser Val Ser Cys Leu Trp Gly Gly Leu Leu Tyr Val Ile
                 325                 330                 335    
 Val Pro Lys Gly Ser Gln Leu Gly Pro Val Pro Val Thr Ile Arg Gly
             340                 345                 350        
 Ala Val Pro Ala Pro Tyr Tyr Lys Leu Gly Lys Thr Ser Leu Glu Glu
         355                 360                 365            
 Trp Lys Arg Gln Met Gln Glu Asn Leu Ala Pro Trp Gly Glu Leu Ala
     370                 375                 380                
 Thr Asp Asn Ile Ile Leu Thr Val Pro Thr Thr Asn Leu Gln Ala Leu
 385                 390                 395                 400
 Lys Asp Pro Glu Pro Val Leu Arg Leu Trp Asp Glu Met Met Gln Ala
                 405                 410                 415    
 Val Ala Arg Leu Ala Ala Glu Pro Phe Pro Phe Arg Arg Pro Glu Arg
             420                 425                 430        
 Ile Val Ala Asp Val Gln Ile Ser Ala Gly Trp Met His Ser Gly Tyr
         435                 440                 445            
 Pro Ile Met Cys His Leu Glu Ser Val Lys Glu Ile Ile Asn Glu Met
     450                 455                 460                
 Asp Met Arg Ser Arg Gly Val Trp Gly Pro Ile His Glu Leu Gly His
 465                 470                 475                 480
 Asn Gln Gln Trp His Gly Trp Glu Phe Pro Pro His Thr Thr Glu Ala
                 485                 490                 495    
 Thr Cys Asn Leu Trp Ser Val Tyr Val His Glu Thr Val Leu Gly Ile
             500                 505                 510        
 Pro Arg Ala Gln Ala His Glu Ala Leu Ser Pro Pro Glu Arg Glu Arg
         515                 520                 525            
 Arg Ile Lys Ala His Leu Gly Lys Gly Ala Pro Leu Cys Asp Trp Asn
     530                 535                 540                
 Val Trp Thr Ala Leu Glu Thr Tyr Leu Gln Leu Gln Gln Ala Phe Gly
 545                 550                 555                 560
 Trp Glu Pro Phe Thr Gln Leu Phe Ala Glu Tyr Gln Thr Leu Ser His
                 565                 570                 575    
 Leu Pro Lys Asp Asn Thr Gly Arg Met Asn Leu Trp Val Lys Lys Phe
             580                 585                 590        
 Ser Glu Lys Val Lys Lys Asn Leu Val Pro Phe Phe Glu Ala Trp Gly
         595                 600                 605            
 Trp Pro Ile Gln Lys Glu Val Ala Asp Ser Leu Ala Ser Leu Pro Glu
     610                 615                 620                
 Trp Gln Glu Asn Pro Met Gln Val Tyr Leu Arg Ala Arg Lys Tyr Ile
 625                 630                 635                 640
 Leu Cys Lys Gly Ser Phe Thr Gly Cys Lys Gly Ala Asn Asn Thr Val
                 645                 650                 655    
 Phe Lys Lys Gly Lys Ala Cys Val Thr Ser Glu Leu Glu Val Gln Gly
             660                 665                 670        
 Lys Pro Leu Arg Thr Lys Gly Lys Gly Trp Asp Gly Met Val Arg Lys
         675                 680                 685            
 Cys Ser Gln Thr Thr Ser Glu Gln Thr Gly Ala Gln Gly Ser Pro Glu
     690                 695                 700                
 Val Ala Asp Val Phe Ser Ser Thr Ile Val Leu Tyr Lys Asn Ser Asn
 705                 710                 715                 720
 Lys Asn Arg Tyr Ile Ser Ser Thr Leu Ser Lys Val Lys Leu Ala Glu
                 725                 730                 735    
 Arg Leu Ser Leu Ala Ser Pro Gly Ser Gly Met Pro Val Ile Thr Gly
             740                 745                 750        
 Arg Phe Ser Cys Tyr Phe Leu Pro Leu Asn Leu Ser Lys Leu Gly Lys
         755                 760                 765            
 Phe Leu Asp Pro His Phe Thr His Gly Phe Lys Ala Val Asp Thr Cys
     770                 775                 780                
 Ile Thr Gly Gln Ile Gly Leu Asp Ala Gly Val Tyr Ala Pro His Cys
 785                 790                 795                 800
 Glu Glu Ala Thr Gln Gly Ser Gln Leu Cys Leu His His Asn Leu Ala
                 805                 810                 815    
 Ser Ala Ala Pro Ile Gln Pro Ala Asp Ser Ile Glu Gln Lys Gly Ala
             820                 825                 830        
 Gln Phe Thr Asn Ser Glu
         835            



      <210> 1501
      <211> 137
      <212> PRT
      <213> Homo sapiens


      <400> 1501
 Met Thr Val Val Met Val Val Met Thr Val Val Val Met Val Ile Arg
   1               5                  10                  15    
 Lys Lys Thr Ile Val Lys Phe Ile Trp Asn Gln Lys Arg Ala Lys Ile
              20                  25                  30        
 Ala Lys Ala Ile Leu Ser Lys Lys Asn Lys Ala Lys Gly Ile Thr Leu
          35                  40                  45            
 Phe Asn Phe Lys Leu Tyr Tyr Lys Ala Asn Val Thr Lys Thr Thr Ser
      50                  55                  60                
 Ser His Gln Thr Trp Gln His Ser Phe Ile Arg Asn Thr Ala Tyr Arg
  65                  70                  75                  80
 His Val Ala Pro Ala Ser Ala Ser Val Ile Thr Trp Leu Ser Pro Cys
                  85                  90                  95    
 Val Cys Ile Leu Ser Ser Ser Tyr Lys Asn Pro Val Met Glu Ile Arg
             100                 105                 110        
 Pro Asn Leu Ile Gln His Asp Leu Ile Ser Val Ile Ile Pro Asn Lys
         115                 120                 125            
 Val Thr Phe Arg Gly Phe Arg Trp Thr
     130                 135        



      <210> 1502
      <211> 282
      <212> PRT
      <213> Homo sapiens


      <400> 1502
 Met Cys Leu Ser Lys Ser Gly Leu Leu Glu Ala Leu Tyr Val Phe Ser
   1               5                  10                  15    
 Cys Pro Leu Met Pro Leu Leu Leu His Gly Ala Trp Glu Glu Cys Ala
              20                  25                  30        
 Pro Ile Ile Leu Leu Val Gln Gly Gly Gly Glu Met Tyr Gln Ala Lys
          35                  40                  45            
 Ile Ser Gly Lys Lys Leu Phe Lys Ile Leu Lys Val Glu Lys Pro Asn
      50                  55                  60                
 Pro Gln Lys Leu Gln Val Arg Thr Ser Thr Ala Gln Gly Asn Leu Leu
  65                  70                  75                  80
 Thr Val Phe Ile Gln Pro Arg Ala Ser Met Ser Gly Gly Lys Tyr Val
                  85                  90                  95    
 Asp Ser Glu Gly His Leu Tyr Thr Val Pro Ile Arg Glu Gln Gly Asn
             100                 105                 110        
 Ile Tyr Lys Pro Asn Asn Lys Ala Met Ala Asp Glu Leu Ser Glu Lys
         115                 120                 125            
 Gln Val Tyr Asp Ala His Thr Lys Glu Ile Asp Leu Val Asn Arg Asp
     130                 135                 140                
 Pro Lys His Leu Asn Asp Asp Val Val Lys Lys Trp Phe Leu Ile Asp
 145                 150                 155                 160
 Leu Arg Ser Leu Phe Arg Lys Lys Lys Asn Asn Asn Asn Asn Asn Thr
                 165                 170                 175    
 Leu Met Thr Leu Lys Glu Ser Asp Thr Ile Asn Ser Ile Ile Gly Val
             180                 185                 190        
 Cys Ala Asn Val Thr Cys Leu Val Thr Leu Asn Ile Asn Met Cys Tyr
         195                 200                 205            
 Gln Ile Asp Thr Arg Gly Gln Lys Arg Ile Lys Ile Cys Thr Ala Cys
     210                 215                 220                
 Phe Val Leu Ser Gln Leu Pro Leu Asp Val Phe Cys Asp Asn Glu His
 225                 230                 235                 240
 Glu Lys Asn Leu Lys Ala Asp Leu Leu Arg Val Cys Ser Val Lys Ser
                 245                 250                 255    
 Val His Thr Val Val Lys Leu Ile Leu Ile Asn Tyr Cys Ile Asp Cys
             260                 265                 270        
 Gly Tyr Thr Pro Leu Leu Pro His Leu Pro
         275                 280        



      <210> 1503
      <211> 607
      <212> PRT
      <213> Homo sapiens


      <400> 1503
 Met Leu Leu Arg Leu Val Trp Ala Gln Ala Gln Gly Asp Pro Asn Ser
   1               5                  10                  15    
 Val Pro Glu Ala Leu Ala Gly Val Ile Gly Asp Pro Ala Gly Lys Pro
              20                  25                  30        
 Arg Pro Leu Arg Lys Asp Gly Ser Glu Leu Gly Leu Lys Met His Ser
          35                  40                  45            
 Asp Arg Arg Pro Ala Ala Pro Val Pro Val Pro His Pro Arg Arg Pro
      50                  55                  60                
 Gln Ser Pro Pro Pro Tyr Pro Gly Pro Pro Pro Pro Ser Pro Pro Thr
  65                  70                  75                  80
 Asn Val Pro Pro Pro His His Gln Cys Asn Ser Tyr Ser Tyr Phe Phe
                  85                  90                  95    
 Ile Ala Leu Ala Asn Asp Tyr Thr Asp Pro His Leu Thr Leu Pro Ser
             100                 105                 110        
 Val Asn Cys Ser Leu Ala Ser Ser Thr Glu Ala Lys Gly Arg Met Pro
         115                 120                 125            
 Leu Pro Tyr Gly Asn Thr Ala Glu Lys Gln His Thr Leu Leu Thr Leu
     130                 135                 140                
 His Phe Ser Gly Glu Val Asn Trp Ile Ala Thr Pro Thr Trp Ser Leu
 145                 150                 155                 160
 Glu Val Lys Glu Arg Leu Gly Ala Ala Thr Tyr Gly Ala Leu Gly Arg
                 165                 170                 175    
 Ser Ser Arg Leu Ala Tyr Gly Cys Pro Gly Glu Ser Ile Thr Ser Gly
             180                 185                 190        
 Ser Glu Gly Phe Gly Ser Ala Phe Ser Ser Ser Ser Thr Pro Phe Val
         195                 200                 205            
 Val Tyr Glu Arg Trp Ala Pro Arg Pro Cys Ala Ser Arg Ala Ala Gly
     210                 215                 220                
 Ala Ala Leu His Arg Ser Asp Lys Pro Ser Ser Leu Ala Ala Arg Leu
 225                 230                 235                 240
 Asp Ala Glu Pro His Gly Ser Leu Pro Asn Ser Cys Leu Trp Glu Cys
                 245                 250                 255    
 Ser Cys Leu Leu Gln Gly Ile Trp Ala Ala Gly Pro Ser Gly Phe Ser
             260                 265                 270        
 Val Leu Ala Trp Gly Ser Asn Phe Gly Leu Thr Val Glu Val Thr Lys
         275                 280                 285            
 Leu Ala Gly Arg Leu Val Leu Ile Arg Ala Gly Arg Gly Gly Trp Val
     290                 295                 300                
 Gly Ser Val Gly Glu Thr Met Thr Ser Ser Tyr Gly His Val Leu Glu
 305                 310                 315                 320
 Arg Gln Pro Ala Leu Gly Gly Arg Leu Asp Ser Pro Gly Asn Leu Asp
                 325                 330                 335    
 Thr Leu Gln Ala Lys Lys Asn Phe Ser Val Ser His Leu Leu Asp Leu
             340                 345                 350        
 Glu Glu Ala Gly Asp Met Val Ala Ala Gln Ala Asp Glu Asn Val Gly
         355                 360                 365            
 Glu Ala Gly Arg Ser Leu Leu Glu Ser Pro Gly Leu Thr Ser Gly Ser
     370                 375                 380                
 Asp Thr Pro Gln Gln Asp Lys Ser Gln Arg Cys Leu Gly Lys Gln Gln
 385                 390                 395                 400
 Val Lys Asp Ala Glu Ser Gly Trp Lys Gly Phe Ser Arg Ala Ala Tyr
                 405                 410                 415    
 Asp Gly Leu Arg Glu Gly Thr Arg His Arg Glu Gln Asp Leu Ala Leu
             420                 425                 430        
 Leu Arg Leu His Ser Pro Arg Gly His Arg Asp Met Trp Pro Asp Met
         435                 440                 445            
 Tyr Arg Tyr Ser Leu Phe Ser Ser Arg Leu Gln Glu Ser Glu Leu Ser
     450                 455                 460                
 Tyr Ser Gln Arg Ile Asp Ile Gln Ile Lys Leu His Ile Glu Thr Ile
 465                 470                 475                 480
 Gly Asn Arg Val Arg Ala Gln Trp Trp Pro Arg Gly Pro Arg Tyr Ser
                 485                 490                 495    
 Lys Pro Gln Arg Glu Pro Leu Ile Leu Gln Gly Lys Arg Asp Glu Asn
             500                 505                 510        
 Cys Thr Gly Cys Leu Ala Leu Ser Gly Arg His Ser Gln Glu Gly Ser
         515                 520                 525            
 Ser Gly Phe Val Val Ala Leu Glu Trp Asn Phe Gly Glu Ile Asp Ser
     530                 535                 540                
 Pro Val Thr Pro Thr His Phe Trp Val Lys Asp Asp Leu Glu Phe Glu
 545                 550                 555                 560
 Val Trp Gly Asp Arg Pro Val Lys Ser Glu Gly Leu Thr Gly Ser Pro
                 565                 570                 575    
 Asp Pro Pro Thr Leu Glu Cys Ser Glu Tyr Pro Pro Pro Cys Phe Arg
             580                 585                 590        
 Ala Ser Leu Pro Cys Val Arg Arg Arg Ala Val Leu His Phe Gly
         595                 600                 605        



      <210> 1504
      <211> 406
      <212> PRT
      <213> Homo sapiens


      <400> 1504
 Met Ala Pro Pro Val Arg Leu Glu Arg Pro Phe Pro Ser Arg Arg Phe
   1               5                  10                  15    
 Pro Gly Leu Leu Leu Ala Ala Leu Val Leu Leu Leu Ser Ser Phe Ser
              20                  25                  30        
 Glu Ser Glu Ala Arg Val Leu Arg Gly Val Pro Cys Ser Asp Pro Gly
          35                  40                  45            
 Gly Met Trp Arg Gly Met Arg Glu Pro Arg Arg Ser Leu Phe Gly Gly
      50                  55                  60                
 Ile Val Cys Ala Ala Asp Ile Tyr Ala Gly Ser Gly Cys Val Pro Lys
  65                  70                  75                  80
 Arg Ser Val Asn Arg Val Phe Gly Ile Glu Pro Ser Gln Gln Gly Glu
                  85                  90                  95    
 Gly Leu Leu Gly Ala Pro Gly Glu Gly Leu Leu Trp Ser Ala Gln Val
             100                 105                 110        
 Arg Gly Ile Val Ala Arg Ala Arg Ala Val Pro Val Val Arg Val Cys
         115                 120                 125            
 Pro Val Phe Pro Trp Cys Leu Val Leu Glu Arg Ser Pro His Asp Leu
     130                 135                 140                
 Leu His Lys Trp Ala Val Ser Ser Ala Ser Ser Ala Gly Met Leu Pro
 145                 150                 155                 160
 Leu Gln Arg Pro Ser Trp Asn Pro Pro Thr Gln Gly Asp Leu Gln Asn
                 165                 170                 175    
 Gly Ile Thr Gly Ser Pro Pro Thr Asp Ser Ser Gly Ile Leu Pro Trp
             180                 185                 190        
 Tyr Glu Pro Glu Asp Lys Leu Lys Thr Arg Val Val Cys Ser Pro Lys
         195                 200                 205            
 Ser Gln Gly Val Arg Thr Leu Gln Ala Glu Glu Asn Ala Tyr Glu Glu
     210                 215                 220                
 Pro Pro Thr Phe Glu Ala Met Glu Leu Ile Gly Lys Pro Lys Pro Tyr
 225                 230                 235                 240
 Tyr Glu Ile Gly Glu Gln Val Asp Tyr Lys Cys Lys Lys Gly His Phe
                 245                 250                 255    
 Tyr Val Pro Pro Leu Ala Thr His Thr Ile Cys Asp Arg Asn His Thr
             260                 265                 270        
 Trp Leu Pro Val Ser Asp Glu Pro Cys Tyr Arg Lys Thr Cys Pro Cys
         275                 280                 285            
 Ile Gly Asp Pro Leu His Gly Gln Ala Val Leu Ala Asn Gly Thr Tyr
     290                 295                 300                
 Glu Leu Gly Tyr Gln Ile His Phe Ile Cys Asn Glu Gly Tyr Tyr Leu
 305                 310                 315                 320
 Ile Gly Lys Glu Ile Leu Tyr Cys Glu Leu Lys Gly Ser Val Ala Val
                 325                 330                 335    
 Trp Ser Ser Lys Pro Pro Ile Cys Glu Thr Leu Ala Pro Gly Ala Leu
             340                 345                 350        
 Gln Ser Ser Ile Trp Glu Met Asp Ser Gln Gly Glu Asn Lys Gly Ser
         355                 360                 365            
 Phe Gln Lys Trp Leu Asp Glu Ile Phe Glu Ile Leu Lys Thr Lys Asn
     370                 375                 380                
 Pro Asn Cys Met Glu Glu Leu Ala Ser Asp Val Val Ser Ser Tyr Asp
 385                 390                 395                 400
 Asn Leu Asp Thr Gln Cys
                 405    



      <210> 1505
      <211> 301
      <212> PRT
      <213> Homo sapiens


      <400> 1505
 Met Ala Ser Cys Tyr Val His Tyr Ala Glu Met Gln Trp Leu Phe Thr
   1               5                  10                  15    
 Gly Met Ile Leu Val His His Ser Leu Lys Leu Leu Ser Ser Ser Asp
              20                  25                  30        
 Ala Leu Thr Ser Ala Ser Gln Leu Lys Ser Leu Leu Leu Leu Glu Gln
          35                  40                  45            
 Arg Glu Ile Trp Leu Leu Val Thr Asp Val Thr Leu Gln Thr Lys Glu
      50                  55                  60                
 Glu Arg Asp Pro Arg Leu Pro Lys Thr Leu Leu Val Tyr Val Ala Pro
  65                  70                  75                  80
 Leu Cys Val Leu Gly Ser Glu Val Leu Glu Ala Leu Ala Gly Ala Ala
                  85                  90                  95    
 Pro His Ser Leu Phe Phe Lys Asp Ala Leu Arg Asp Gln Gly Arg Ile
             100                 105                 110        
 Val Cys Ala Glu Arg Thr Val Leu Leu Leu Gln Lys Pro Leu Leu Ser
         115                 120                 125            
 Val Val Ser Gly Ala Ser Ser Cys Glu Leu Pro Gly Pro Val Met Leu
     130                 135                 140                
 Asp Ser Leu Asp Ser Ala Thr Pro Val Asn Ser Ile Cys Ser Val Gln
 145                 150                 155                 160
 Gly Thr Val Val Gly Val Asp Glu Ser Thr Ala Phe Ser Trp Pro Val
                 165                 170                 175    
 Cys Asp Met Cys Gly Asn Gly Arg Leu Glu Gln Arg Pro Glu Asp Arg
             180                 185                 190        
 His Leu Gln Val Phe Leu Asp Cys Arg Ser Arg Pro Gln Cys Arg Val
         195                 200                 205            
 Lys Val Lys Val Gly Ala Arg Pro Glu His Ala Arg Thr Pro Ser Ser
     210                 215                 220                
 Leu Gln His Ser Glu Gly Glu Thr Glu Leu Lys Gln Leu Leu Gln Arg
 225                 230                 235                 240
 Ser Ile Ser Ser Leu Leu Arg Phe Ala Ala Gly Glu Asp Gly Ser Tyr
                 245                 250                 255    
 Glu Val Lys Ser Val Leu Gly Lys Glu Val Gly Leu Leu Asn Cys Phe
             260                 265                 270        
 Val Gln Ser Val Thr Ala His Pro Thr Ser Cys Ile Gly Leu Glu Glu
         275                 280                 285            
 Ile Glu Leu Leu Ser Ala Gly Gly Ala Ser Ala Glu His
     290                 295                 300    



      <210> 1506
      <211> 338
      <212> PRT
      <213> Homo sapiens


      <400> 1506
 Met Gly Ser Glu Thr Tyr Thr Leu Leu Leu Met Leu Leu Leu Glu Pro
   1               5                  10                  15    
 Gln Leu Pro Thr Lys Thr Gly Lys Gln Glu Arg Lys Gly Thr Gly Phe
              20                  25                  30        
 Tyr Lys Leu Leu Glu Gly Val Arg Lys Leu Arg Ile Gln Phe Ser Glu
          35                  40                  45            
 Ile Gly Phe Glu Thr Asn Gln Asp Glu Val Leu Asn Ala Leu Ala Val
      50                  55                  60                
 Gln Cys Ile Tyr Asp Ser Tyr Leu Arg Ser Glu Ala Ala His Trp Arg
  65                  70                  75                  80
 Cys Phe Gln Glu Asn Ile Lys Thr Arg Phe His Tyr Val Asp Trp Ile
                  85                  90                  95    
 Lys Lys Met Cys Tyr Ile Tyr Thr Met Glu Tyr Tyr Ala Ala Ile Lys
             100                 105                 110        
 Lys His Lys Ile Val Ser Phe Ala Ala Thr Trp Met His Leu Lys Ala
         115                 120                 125            
 Ile Ile Leu Ser Lys Leu Met Gln Lys Gln Lys Ala Lys Tyr Cys Met
     130                 135                 140                
 Phe Ser Leu Ile Glu Val Glu Lys Ser Lys Ile Lys Ala Leu Asn Leu
 145                 150                 155                 160
 Arg Met Gln Gln Gln Gly Thr Ser Leu Glu Ala Glu Ile Lys Pro Leu
                 165                 170                 175    
 Ser Asp Ala Lys Pro Ala Tyr Ala Leu Ile Trp Asp Phe Pro Ala Ser
             180                 185                 190        
 Arg Thr Met Arg Asn Lys Phe Leu Leu Phe Val Asn Tyr Pro Val Tyr
         195                 200                 205            
 Gly Leu Gln Glu Lys Gly Glu Glu Ser Leu Gln Val Ala Leu Cys Gly
     210                 215                 220                
 Glu Ser His Pro Thr Gly Met Val Ala Phe Ile Lys Glu Cys Ser Gln
 225                 230                 235                 240
 Pro Gly Glu Pro Ser Pro Gln Gly Ser Lys Ala Asn Arg Tyr Phe Thr
                 245                 250                 255    
 Leu Ser Phe Leu Leu Pro Ser His Val Leu Pro Val Phe Ser Ile Gly
             260                 265                 270        
 Gln Ala Gln Pro Arg Ile Gln Lys Thr Arg Glu Ser Ala Asp Thr Ala
         275                 280                 285            
 His Pro Val Cys Pro Gln Thr Lys Asp Gly His Val Arg Ile Pro Gln
     290                 295                 300                
 Arg Leu Val Asp Cys Ala Ala Ala Asp Val Gly Arg Arg Arg Phe Phe
 305                 310                 315                 320
 Gly Lys Gln Gly Gly Phe Glu Gln Thr Asn Asp Leu Gly Lys Arg Lys
                 325                 330                 335    
 Asp Lys
        



      <210> 1507
      <211> 258
      <212> PRT
      <213> Homo sapiens


      <400> 1507
 Met Leu Ile Gly Thr Phe Trp Ile Leu Asp Phe His Ile Trp Asp Thr
   1               5                  10                  15    
 Gln Leu Arg Leu Lys Pro Thr Asn Pro Ala Ala Gln Lys Ala Leu Thr
              20                  25                  30        
 Thr Pro Thr His Tyr Lys Leu Thr Pro Arg Pro Ala Thr Arg Val Arg
          35                  40                  45            
 Pro Lys Ala Leu Gln Thr Thr Gly Thr Ala Lys Ser His Leu Phe Asp
      50                  55                  60                
 Gly Leu Asp Asp Asp Glu Pro Ser Leu Ala Asn Gly Ala Phe Met Pro
  65                  70                  75                  80
 Lys Lys Ser Ile Lys Lys Leu Val Leu Lys Asn Leu Asn Asn Ser Asn
                  85                  90                  95    
 Leu Phe Ser Pro Val Asn Arg Asp Ser Glu Asn Leu Ala Ser Pro Ser
             100                 105                 110        
 Glu Tyr Pro Glu Asn Gly Glu Arg Phe Ser Phe Leu Ser Lys Pro Val
         115                 120                 125            
 Asp Glu Asn His Gln Gln Asp Gly Asp Glu Asp Ser Leu Val Ser His
     130                 135                 140                
 Phe Tyr Thr Asn Pro Ile Ala Lys Pro Ile Pro Gln Thr Pro Glu Ser
 145                 150                 155                 160
 Ala Gly Asn Lys His Ser Asn Ser Asn Ser Val Asp Asp Thr Ile Val
                 165                 170                 175    
 Ala Leu Asn Met Arg Ala Ala Leu Arg Asn Gly Leu Glu Gly Ser Ser
             180                 185                 190        
 Glu Glu Thr Ser Phe His Asp Glu Ser Leu Gln Asp Asp Arg Glu Glu
         195                 200                 205            
 Ile Glu Asn Asn Ser Tyr His Met His Pro Ala Gly Gln Val Gln Ile
     210                 215                 220                
 Gly Ala Cys Leu Ile Ser Tyr Gln Ser Phe Glu Met Thr Cys Leu Leu
 225                 230                 235                 240
 Gln Ile Phe Asn Ile Trp Lys Ser Ala Val Trp His Phe Lys Tyr Tyr
                 245                 250                 255    
 Phe Met
        



      <210> 1508
      <211> 707
      <212> PRT
      <213> Homo sapiens


      <400> 1508
 Met Ala Pro Ala Ala Pro Ala Thr Leu Ala Thr Trp Met Ala Thr Phe
   1               5                  10                  15    
 Ser Gly Cys Cys Thr Gly Ala Gly Thr Cys Asp Asn Arg Val Pro Asp
              20                  25                  30        
 Thr Val Leu Thr Cys Asp Asn Arg Val Pro Asp Thr Val Leu Thr Cys
          35                  40                  45            
 Asp Asn Arg Val Pro Asp Thr Val Leu Thr Cys Asp Asn Arg Val Pro
      50                  55                  60                
 Asp Thr Val Leu Thr Cys Asp Asn Arg Cys Val Ser Thr His Ile His
  65                  70                  75                  80
 Thr Tyr Thr His Ser Gly Arg Glu His Arg Ser Thr Pro Leu Ser Leu
                  85                  90                  95    
 Arg Ala Phe Pro Pro Ala Gly Ser Thr Glu Glu Gly Asn Ile Arg Ser
             100                 105                 110        
 Leu Met Ser Thr Glu Lys Thr Lys Gly Phe Cys Gln Leu Val Val Ser
         115                 120                 125            
 Ser Ser Leu Arg Asp Gly Met Ser His Leu Ile Gln Ser Ala Gly Leu
     130                 135                 140                
 Gly Gly Leu Lys His Asn Thr Val Leu Met Ala Trp Pro Ala Ser Trp
 145                 150                 155                 160
 Lys Gln Glu Asp Asn Pro Phe Ser Trp Lys Asn Phe Val Asp Thr Val
                 165                 170                 175    
 Arg Asp Thr Thr Ala Ala His Gln Ala Leu Leu Val Ala Lys Asn Val
             180                 185                 190        
 Asp Ser Phe Pro Gln Asn Gln Glu Arg Phe Gly Gly Gly His Ile Asp
         195                 200                 205            
 Val Trp Trp Ile Val His Asp Gly Gly Met Leu Met Leu Leu Pro Phe
     210                 215                 220                
 Leu Leu Arg Gln His Lys Val Trp Arg Lys Cys Arg Met Arg Ile Phe
 225                 230                 235                 240
 Thr Val Ala Gln Val Asp Asp Asn Ser Ile Gln Met Lys Lys Asp Leu
                 245                 250                 255    
 Gln Met Phe Leu Tyr His Leu Arg Ile Ser Ala Glu Val Glu Val Val
             260                 265                 270        
 Glu Met Val Glu Asn Asp Ile Ser Ala Phe Thr Tyr Glu Arg Thr Leu
         275                 280                 285            
 Met Met Glu Gln Arg Ser Gln Met Leu Lys Gln Met Gln Leu Ser Lys
     290                 295                 300                
 Asn Glu Gln Glu Arg Glu Pro Thr Thr Val Leu Gln Arg Ala Cys Leu
 305                 310                 315                 320
 Arg Asn Leu Gln Tyr Thr Gly Leu Arg Val Gly Pro Tyr Val Leu Thr
                 325                 330                 335    
 Ala Gly Ile Thr Lys Gln Arg Leu Leu Leu Ser Pro Asn Arg Glu Arg
             340                 345                 350        
 Arg Val Glu Leu Arg Ser Cys Pro Leu Pro Asp Pro Gly Gln Ala Arg
         355                 360                 365            
 Ser Leu Arg Ser Gly Arg Val Ala Leu Ala Ser Gln Gly Phe Ser Pro
     370                 375                 380                
 Gly Pro Ala Arg Asn Lys Asn Pro Pro Met Ala Ser Trp Glu Val Gln
 385                 390                 395                 400
 Cys Gly Glu Ser Ala Asn Ala Asp Arg Gly Gly Thr Gly Ser Gly Asn
                 405                 410                 415    
 Ser Lys Leu Glu Leu Glu Gly Pro Leu Leu Gly Gln Ala Gln Leu Ile
             420                 425                 430        
 His Asp Arg Asn Thr Ala Ser His Thr Ala Ala Ala Ala Arg Thr Gln
         435                 440                 445            
 Ala Pro Pro Thr Pro Asp Lys Val Gln Met Thr Trp Thr Arg Glu Lys
     450                 455                 460                
 Leu Ile Ala Glu Lys Tyr Arg Ser Arg Asp Thr Ser Leu Ser Gly Phe
 465                 470                 475                 480
 Lys Asp Leu Phe Ser Met Lys Pro Pro Gly Ser Phe Ser Ser Asn Gly
                 485                 490                 495    
 Cys Thr Gly Arg Asp Gln Ser Asn Val Arg Arg Met His Thr Ala Val
             500                 505                 510        
 Lys Leu Asn Gly Val Val Leu Asn Lys Ser Gln Asp Ala Gln Leu Val
         515                 520                 525            
 Leu Leu Asn Met Pro Gly Pro Pro Lys Asn Arg Gln Gly Asp Glu Asn
     530                 535                 540                
 Cys Ile Leu Ser Cys Ser Val Pro Ala Glu Arg Ala Gly Thr Pro Trp
 545                 550                 555                 560
 Trp Leu Leu Ala Lys Thr Trp Ala Gln Gln Ile Arg Ala Trp Leu Asp
                 565                 570                 575    
 Asp Phe Leu Ala Ser Glu Gly Arg Arg Cys Tyr Arg Ser Asp Leu Asp
             580                 585                 590        
 Val Ala Arg Ser Ser Arg Arg Ser Gln Glu Ala Ser Glu Pro Leu Pro
         595                 600                 605            
 Trp Phe Leu Glu Val Leu Phe Leu Gly Trp Ile Tyr Pro Val Val Arg
     610                 615                 620                
 Leu His Phe Tyr Pro Ile Gln Asn Ile Leu Gly Arg Ala Pro Gly Ala
 625                 630                 635                 640
 Glu Ala Val Pro Asp Asp Glu Gly Glu Thr Ser Ala Leu Ala Met Ala
                 645                 650                 655    
 Pro Leu Arg Ala Pro Val Thr Ser Glu Ser Leu Cys Ser Leu Thr Val
             660                 665                 670        
 Phe Val Phe Leu Tyr Leu Lys Ala Leu Lys Leu Glu Asp Ser Val His
         675                 680                 685            
 Ala Arg Val Thr Leu Val Trp Glu Pro Leu Gly Ser Ala Gly Pro His
     690                 695                 700                
 Phe Met Ser
 705        



      <210> 1509
      <211> 146
      <212> PRT
      <213> Homo sapiens


      <400> 1509
 Met Ile Pro Phe Trp Lys Ala Leu Gly Cys Val Ala Ala Met Ala Glu
   1               5                  10                  15    
 Val Lys Gly Ser Cys Gly Ser Ser Ser Trp Val Ser Val Leu Lys Val
              20                  25                  30        
 Ser Phe Ser Ala Leu Thr Leu Cys Ser Thr Arg Ser Lys Ser Ser Ser
          35                  40                  45            
 Thr Ser Lys Ser Leu Asn Ala Ile Pro Val Val Val Gln Ser Leu Pro
      50                  55                  60                
 Met Val Tyr Thr Thr Leu Pro Ala Asn Glu Gly Pro Ala Pro Asn Thr
  65                  70                  75                  80
 Val Pro Leu Ile Gly Gly Asp Gly Thr Asn Ala Gly Ser Val Lys Val
                  85                  90                  95    
 Asp Pro Ala Phe Met Ser Leu Leu Glu Ile Pro Ser Asp Ser Glu Glu
             100                 105                 110        
 Ser Ala Ile Lys Ser Gly Ser Ser Ile Ser Gln Ser Leu Gln Gly Leu
         115                 120                 125            
 Pro Leu Ser Val Leu Pro Val Gly Ala Pro Trp Gly Ser Ala Ser Ser
     130                 135                 140                
 Pro Val
 145    



      <210> 1510
      <211> 444
      <212> PRT
      <213> Homo sapiens

      <220>
      <221> misc_feature
      <222> (1)...(444)
      <223> Xaa = any amino acid or nothing 


      <400> 1510
 Met Arg Xaa Lys Leu Leu Cys Ser Val Ile Thr Ala Met Leu Lys Phe
   1               5                  10                  15    
 Trp Trp Pro Leu Leu Asn Pro Ser Asn Pro Asn Ser Ile Thr Lys Gly
              20                  25                  30        
 Arg Ile Gln Ser Ala His Phe Thr Ser His Leu Gly His Val Glu Thr
          35                  40                  45            
 Val Gln Thr Ser Glu Arg Arg Thr Arg Glu Lys Glu Gly Ser Pro Arg
      50                  55                  60                
 Lys Lys Pro His Lys Asn Lys Lys Arg Pro Pro Thr Lys Thr Gly Ser
  65                  70                  75                  80
 Pro Asn Gln Thr Ser Arg Asp Ala Glu Gly Gly Thr Gly His Lys Pro
                  85                  90                  95    
 Thr Ala Pro Gln Lys Ala Gln Lys Lys Ala Glu Asn Thr Gln Leu Lys
             100                 105                 110        
 Leu Arg Pro Arg His Lys His Thr Ser Asp Ser Ser Asn His Ser Lys
         115                 120                 125            
 Ser Gln Arg Arg Asn Pro Leu Leu Phe Thr Leu Glu Ile Gln Thr Thr
     130                 135                 140                
 Ile Arg Glu Tyr Tyr Lys His Leu Tyr Ala Asn Lys Leu Glu Asn Leu
 145                 150                 155                 160
 Glu Glu Met Asp Lys Phe Leu Asp Thr Tyr Thr Leu Pro Arg Leu Asn
                 165                 170                 175    
 Gln Glu Glu Val Glu Ser Leu Asn Arg Pro Ile Thr Gly Ser Glu Thr
             180                 185                 190        
 Val Ala Ile Ile Asn Ser Leu Pro Thr Lys Lys Ser Pro Gly Pro Asp
         195                 200                 205            
 Gly Phe Thr Ala Glu Phe Tyr Gln Arg Tyr Lys Glu Glu Leu Arg Ile
     210                 215                 220                
 Lys Tyr Leu Glu Ile Gln Leu Thr Arg Asp Val Lys Asp Leu Phe Lys
 225                 230                 235                 240
 Glu Asn Tyr Lys Pro Leu Leu Lys Glu Ile Lys Glu Asp Thr Asn Lys
                 245                 250                 255    
 Trp Lys Asn Ile Pro Cys Ser Trp Val Arg Arg Ile Asn Ile Val Lys
             260                 265                 270        
 Met Ala Ile Leu Pro Lys Arg Ile Lys Tyr Leu Gly Ile Gln Leu Thr
         275                 280                 285            
 Arg Asp Val Lys Asp Leu Phe Lys Glu Asn Tyr Lys Pro Leu Leu Asn
     290                 295                 300                
 Glu Ile Lys Glu Asp Thr Asn Lys Trp Lys Asn Ile Pro Cys Ser Trp
 305                 310                 315                 320
 Ile Gly Arg Ile Asn Ile Met Lys Met Ala Ile Leu Pro Lys His Lys
                 325                 330                 335    
 Gln Asp Asp Met Glu Val Lys Thr Glu Asn Arg Arg Gly Gln Gln Lys
             340                 345                 350        
 Lys Met Ala Lys Pro Ile Pro Glu Lys Gly Asp Ile Arg Arg Arg Arg
         355                 360                 365            
 Leu Tyr Pro Pro Ile Gly Glu Leu Ser Thr Ser Gly Gly Glu Gly Phe
     370                 375                 380                
 Phe Phe Ser Ser Arg Trp Phe Ser Gln Arg Ser Val Ile Ser Glu Val
 385                 390                 395                 400
 Pro Pro Glu Lys Ala Thr Val Ile Thr His Leu Asp Asp Cys Arg Arg
                 405                 410                 415    
 Leu Leu Thr Ile Arg Leu Ser Val Phe Pro Thr Ser Asn Leu Ala Met
             420                 425                 430        
 Ala His Ser Thr Asn Thr Cys Cys Val Pro Thr Met
         435                 440                



      <210> 1511
      <211> 450
      <212> PRT
      <213> Homo sapiens


      <400> 1511
 Met Asn Cys Ala Leu His Pro Leu Ser Cys Ile Cys Cys Leu Ala Leu
   1               5                  10                  15    
 Pro Ile Glu Met Asn Leu Val Pro Gln Met Glu Met Gln Lys Ser Pro
              20                  25                  30        
 Val Phe Cys Ile Ala Asp Thr Gly Ser Cys Arg Pro Glu Leu Phe Leu
          35                  40                  45            
 Phe Gly His Leu Gly Tyr Thr Trp Ile Ala Glu His Cys Tyr Asp Tyr
      50                  55                  60                
 Leu Asn Val Val Pro His Lys Val Leu Gln Ser Thr Ala Ala Gly Phe
  65                  70                  75                  80
 Ser Leu Phe Ala Pro His Ile Gly Leu Gln Asn Thr Ala Ala Arg Phe
                  85                  90                  95    
 Glu Gly Phe Gln Asn Thr Ala Ala Gly Phe Leu Val Phe Asp Pro His
             100                 105                 110        
 Ile Gly Phe Gln Asn Thr Ala Ala Gly Phe Arg Val Phe Leu Pro His
         115                 120                 125            
 Ile Gly Phe Gln Asn Thr Ala Ala Arg Phe Cys Val Cys Pro Ser His
     130                 135                 140                
 Ser Ile Pro Glu His Arg Lys Arg Leu Arg Arg Ser Glu Phe Leu Ser
 145                 150                 155                 160
 Ile Thr Lys Asp Phe Arg Thr Leu Leu Leu Asp Leu Ser Val Cys Pro
                 165                 170                 175    
 Ser His Arg Ile Pro Glu His Cys Phe Asp Gly Leu Asn Asp Ser Gly
             180                 185                 190        
 Thr Leu Leu Arg Gly Ser Glu Cys Leu Ser Leu Thr Lys Asp Tyr Arg
         195                 200                 205            
 Thr Val Leu Glu Ser Tyr Val Arg Asp Lys His Ser Glu Pro Ser Ser
     210                 215                 220                
 Val Leu Glu Ser Tyr Val Arg Asp Val Ala Ile Glu Phe Cys Leu Glu
 225                 230                 235                 240
 Glu Cys Gln Tyr Leu Asp Ala Ala Gln Gln Asn Leu Cys Met Asp Val
                 245                 250                 255    
 Met Leu Gln Asn Tyr Arg Asn Pro Val Phe Leu Val Glu Asp Asn Phe
             260                 265                 270        
 Asn Ile Glu Phe Leu Ile Tyr Pro Lys Gly Phe Ile Phe Phe Leu Cys
         275                 280                 285            
 Arg Met Cys Phe Ala Arg Pro Gly His Leu Ser Gly Ala Lys Glu Lys
     290                 295                 300                
 Ala Met Glu Tyr Glu Ala Pro Arg Ser Glu Pro Pro Cys Pro Ala Phe
 305                 310                 315                 320
 Leu Ala Asp Phe Gln Gln Leu Ser Tyr Tyr Val Lys Arg Ile His Ser
                 325                 330                 335    
 Gly Glu Lys Pro Tyr Lys Cys Glu Glu Cys Gly Lys Ala Phe Lys Gln
             340                 345                 350        
 Ser Ser Lys Leu Asn Glu His Met Lys Ala His Thr Gly Glu Lys Phe
         355                 360                 365            
 Tyr Lys Cys Glu Glu Cys Gly Lys Ala Phe Lys Gln Pro Ser Gly Leu
     370                 375                 380                
 Thr Leu His Lys Arg Ile His Thr Gly Glu Asn Pro Tyr Lys Phe Glu
 385                 390                 395                 400
 Glu Cys Gly Thr Trp Met Lys Leu Glu Ile Ile Ile Leu Ser Lys Leu
                 405                 410                 415    
 Ser Gln Glu Gln Lys Thr Lys His Arg Ile Phe Ser Leu Ile Gly Cys
             420                 425                 430        
 His Ser Thr Gln Thr Glu Gly Leu Ala Glu Ala Met Ala Glu Glu Cys
         435                 440                 445            
 Gly Leu
     450



      <210> 1512
      <211> 940
      <212> PRT
      <213> Homo sapiens


      <400> 1512
 Met Ile Arg His Cys Pro Ala Phe Ser His Arg Cys Val Lys His Ala
   1               5                  10                  15    
 Gln Ser Val Gln Thr Leu Leu Ala Phe Val Val Phe Ile Lys Gly Phe
              20                  25                  30        
 Ile Glu Leu Leu Ile Lys Thr Ala Val Tyr Lys Thr Thr Pro Leu Lys
          35                  40                  45            
 Asp Phe Pro Gly Leu Pro Pro Ala Gln Leu Ala Asp Tyr Phe Gln Pro
      50                  55                  60                
 Met Lys Thr Ser Phe Gly Glu Cys Leu Ser Ala Gln His Val Val Glu
  65                  70                  75                  80
 Asp Ser Ala Arg Leu Cys Leu Leu Thr Ser Ser Ile Val His Ala Gln
                  85                  90                  95    
 Leu Gln Asp Arg Gln Ala Pro Gly Asn Arg Pro Pro Tyr Phe Ser Glu
             100                 105                 110        
 Thr Gly Ile Trp Leu Thr Gly Gly Trp Lys Ala Val Leu Asp Ser Phe
         115                 120                 125            
 Thr Ser Arg Asp Pro Val Leu Pro Ser His Cys Lys Ser Pro Ser Pro
     130                 135                 140                
 Cys Ser Gly Ser Thr Lys Arg Gly His Gly Tyr Ala Phe Gly Trp Lys
 145                 150                 155                 160
 Asn Glu Gln Ala Val Phe Thr Thr Cys Arg Val Lys Thr Gly Thr Gln
                 165                 170                 175    
 Lys Gly Met Asp Lys Cys Glu Cys Val Trp Gln Gly Ala Glu Leu Ile
             180                 185                 190        
 Cys Lys Leu Leu Leu Leu Pro Gly Ser Gln Lys Val Glu Lys Ala Pro
         195                 200                 205            
 Tyr Ser Asn Pro Asp Asp Ser Lys Phe Ile Ile Ser Ser Ser Ile Ala
     210                 215                 220                
 Pro Arg His Ala Leu Ile Phe Arg Ser Tyr Gly Asp Phe Ile Leu Arg
 225                 230                 235                 240
 Ser Ser Lys Gly Ile Trp Arg Glu Gly His Ser Ser Ser Thr Lys Lys
                 245                 250                 255    
 Leu Met Asn Pro Val Phe Thr Ser Pro Thr Gln Ser Leu Trp Glu Cys
             260                 265                 270        
 Gln Gly Arg Ile Cys Ile Phe Cys Trp Thr Asn Pro Pro Asp Tyr Leu
         275                 280                 285            
 Thr Gly Thr Ser Asn Ser Leu Asp Pro Ile Leu Gln Glu Gln Thr Ala
     290                 295                 300                
 Ser Phe Ser Leu Ala Thr Ala Phe Gln Val Ser Ile Gln Arg Pro Glu
 305                 310                 315                 320
 His His Gly His Ser Val Lys Ile Ser Arg Ala Glu Asn Ile Met Leu
                 325                 330                 335    
 Ala Glu Lys Ser Gln Thr Thr Lys Asp Met Glu Pro Glu Ala Gln Arg
             340                 345                 350        
 Asp Ser Leu Gln Ala Glu Val Leu Leu Gln Gln Ala Gly Ala Leu Glu
         355                 360                 365            
 Asp Ser Ser His Gln Asp Gln Asn Ile Ser Val Arg Ile Asp Gln Asn
     370                 375                 380                
 Arg Gly Leu Arg Ser Arg Arg His Asp Val Asp Phe Arg Asp Thr Arg
 385                 390                 395                 400
 Asn Ser Ala Glu Pro Cys Tyr Pro Arg Ala Gly Thr Asn Leu Ser Ser
                 405                 410                 415    
 Asp Glu Lys Ser Arg Thr Leu Ser Gly Ala Gly Glu Gly Trp Asp Glu
             420                 425                 430        
 Ser Phe Met Lys Met Asn Leu Thr Ala Thr Gly Glu Gly Ala Ser Gly
         435                 440                 445            
 Glu Ser Gly Ser Asp Pro Ala Lys Ala Thr Leu Val Met Glu Lys Gly
     450                 455                 460                
 Met Glu Lys Arg Lys Glu Gly Asp Gly Cys Val Trp Gly Ile Phe His
 465                 470                 475                 480
 Ala Lys His Ser Gln Ala Gly Thr Gly Ser Val Gly Cys Ser Ala Asp
                 485                 490                 495    
 Glu Arg Glu Glu Leu Gly Val Ala Gln Glu Ser Met Arg Thr Gly Gly
             500                 505                 510        
 Lys Ile Thr Arg Arg Ala Phe Lys Asn Thr Cys Ile Arg Gly Leu Gly
         515                 520                 525            
 Thr Ser Glu Glu Ala Gln Glu Glu Gln Lys Gln Ser His Pro Asn Gln
     530                 535                 540                
 Ser Lys Pro Val Leu Ser Asn Met Ala Ala Thr Met His Leu Arg Pro
 545                 550                 555                 560
 Gly Gln Met Asp Asp Ile Tyr Ile Arg Glu Glu Lys Ser Ala Ala Leu
                 565                 570                 575    
 Ala Met Ser Ile His Phe Ile Ile Ser Ala Val Phe Val Asn Tyr Asn
             580                 585                 590        
 Thr Pro Ser Trp Asn Thr Asn Thr Arg Phe Ser Gln Glu Ser Thr Glu
         595                 600                 605            
 Pro Ala Ile Arg Gly Leu Val Ser Asp Asn Ser Asn Asn Met Leu Glu
     610                 615                 620                
 Leu Gly His Gly Glu Gly Leu Asn Ala Gly Gln Arg Asn Leu Asp Phe
 625                 630                 635                 640
 Ile Phe Gly Trp Gly Glu Leu Val Gln Thr Ser Asp Gly Gly Thr Asp
                 645                 650                 655    
 Lys Met His Asn Asp Thr Glu Ala Gly Ala Arg Asp Trp Val Ser Gly
             660                 665                 670        
 Ser Pro Trp Leu Val Val Val Leu Pro Thr Arg Arg Gly Trp Ala Arg
         675                 680                 685            
 Gln Ser Leu Lys Phe Pro His Thr Arg Arg Lys Ser Leu Ser Pro Gly
     690                 695                 700                
 Arg Glu Leu Tyr Phe Gln Glu Met Tyr Leu Ala Leu Met Glu Pro Glu
 705                 710                 715                 720
 Ala Arg Ser Leu Arg Thr Thr Glu Glu Ala Thr Gly Thr Val Gln Glu
                 725                 730                 735    
 Thr Cys Gln His Glu Asp Gln Ser Met Val Ser Glu Ala Glu Ser Gly
             740                 745                 750        
 Ser Asn Ile Glu Met Pro Ala Ala Leu Lys Lys Glu Lys Tyr Ile Gly
         755                 760                 765            
 Leu Met His Leu Val Lys Asn Ser Arg Ser Cys Lys Ser Arg Thr Leu
     770                 775                 780                
 Leu Lys Gly Thr Gln Lys Asn Gly Val Arg Asn Ile Arg Met Gly Leu
 785                 790                 795                 800
 Lys His His Tyr Val Leu Leu Glu Gly Arg Lys Arg His Asp Ala His
                 805                 810                 815    
 Gln Thr Pro Leu Leu Phe Leu Pro Gly His Ile Gly Lys Glu Ile Leu
             820                 825                 830        
 Gln Ala Pro Leu Gln Glu Thr Val Ser Val Gly Asn Lys Asp Lys Cys
         835                 840                 845            
 Gly Asn Arg Gln Val Phe Lys Lys Glu Thr Ser Ser Ala Gln Ser Leu
     850                 855                 860                
 Ser Ser Ala Ile Glu Ile Arg Gln Met Leu Ala Leu Arg Ala Pro Arg
 865                 870                 875                 880
 Lys Ala Ile Glu Val Cys Leu Ile His Leu Phe Gln Leu Gln Gly Thr
                 885                 890                 895    
 Lys Gln Gln Thr Ser Arg Ala Val Val Asn Glu Glu Cys Leu Ser Gly
             900                 905                 910        
 Pro Leu Arg Glu Gly Gly Ala Val Ser Ser Thr Ser Trp Lys Leu Leu
         915                 920                 925            
 Lys Ser Gln Gly Phe Lys Leu Ser Ser Ser Asp Ser
     930                 935                 940



      <210> 1513
      <211> 441
      <212> PRT
      <213> Homo sapiens


      <400> 1513
 Met Pro Met Arg Gly Cys Leu Arg Thr Val Leu Gly Leu Pro Pro Trp
   1               5                  10                  15    
 Gly Ala Gln Asn Ala His Ala Gly Met Pro Thr Arg Gly Ala Gln Asp
              20                  25                  30        
 Val Tyr Ala Gly Met Pro Thr Arg Gly Ala Gln Asp Val Tyr Ala Gly
          35                  40                  45            
 Met Pro Thr Arg Gly Ala Gln Asp Val Tyr Ala Gly Met Pro Thr Arg
      50                  55                  60                
 Gly Ala Gln Asp Val Tyr Ala Gly Met Pro Thr Trp Gly Ala Gln Asp
  65                  70                  75                  80
 Val Tyr Ala Gly Met Pro Thr Trp Gly Phe Leu Gly Cys Leu Cys Gly
                  85                  90                  95    
 Met Ser Ala Gly Val Arg Asp Ala Ser Thr Gly Leu Pro Thr His Gly
             100                 105                 110        
 Ala Arg Gly Ala Tyr Arg Gly Met Pro Thr Trp Val Leu Gly Met Pro
         115                 120                 125            
 Thr Gly Arg Cys Pro Arg Arg Ala Ala Arg Asp Ala Cys Asn Ser Arg
     130                 135                 140                
 Gly Lys Arg Leu Gln His Cys Tyr Phe Ser Gly Thr Thr Leu Gln Cys
 145                 150                 155                 160
 Leu Pro Leu Gly Ser Phe Tyr Asp Pro Phe Gly Val Pro Leu His Gly
                 165                 170                 175    
 Gln Trp Ser Glu Thr Pro Asp Ser Gly Thr Lys His Lys Gln Glu Asn
             180                 185                 190        
 Ala Phe Cys Leu Ser Thr Leu Glu Ile Glu Asn Arg Ala Gln Asp Leu
         195                 200                 205            
 His Leu Phe Glu Thr Leu Lys Thr Asp Pro Glu Ala Phe His Gln His
     210                 215                 220                
 Met Val Lys Tyr Ile Tyr Pro Thr Ile Gly Gly Phe Asp His Glu Arg
 225                 230                 235                 240
 Leu Gln Tyr Tyr Phe Thr Leu Leu Glu Asn Cys Gly Cys Ala Asp Leu
                 245                 250                 255    
 Gly Asn Cys Ala Ile Lys Pro Glu Thr His Ile Arg Leu Leu Lys Lys
             260                 265                 270        
 Phe Lys Val Val Ala Ser Gly Leu Asn Tyr Lys Lys Leu Thr Asp Glu
         275                 280                 285            
 Asn Met Ser Pro Leu Glu Ala Leu Glu Pro Val Leu Ser Ser Gln Asn
     290                 295                 300                
 Ile Leu Ser Ile Ser Lys Leu Val Pro Lys Ile Pro Glu Lys Asp Gly
 305                 310                 315                 320
 Gln Met Leu Ser Pro Ser Ser Leu Tyr Thr Ile Trp Leu Gln Lys Leu
                 325                 330                 335    
 Phe Trp Thr Gly Asp Pro His Leu Ile Lys Gln Val Pro Gly Ser Ser
             340                 345                 350        
 Pro Glu Trp Leu His Ala Tyr Asp Val Cys Met Lys Tyr Phe Asp Arg
         355                 360                 365            
 Leu His Pro Gly Asp Leu Ile Thr Val Val Asp Ala Val Thr Phe Ser
     370                 375                 380                
 Pro Lys Ala Val Thr Lys Cys Leu Leu Leu His Gln Val Val Ala Pro
 385                 390                 395                 400
 Ile Gly Cys Lys Ile Ala Ala Ile Ala Gly Cys Arg Leu Asp Ser Gln
                 405                 410                 415    
 Gly Asp Leu Phe Ile Asn Gly Asp Gly Lys Gln Ile Thr Gln Leu Lys
             420                 425                 430        
 Met Trp Arg Gln Lys Gly Arg Asn Gly
         435                 440    



      <210> 1514
      <211> 517
      <212> PRT
      <213> Homo sapiens


      <400> 1514
 Met Met Leu Phe Ile Asn Ala Asn Cys Leu Cys Phe His Ser Val Tyr
   1               5                  10                  15    
 Val Trp Ala Lys Ile Leu Ala Thr Leu Ile Ile Val Thr Gly Phe Gln
              20                  25                  30        
 Leu Phe His Leu Ser Glu Val Ala Val Glu Thr Asn Phe Leu Ser Gly
          35                  40                  45            
 Met His Lys Glu Leu Pro Phe Leu Gln Phe Phe Arg Lys Pro Val Ile
      50                  55                  60                
 Tyr Ser Ile Leu Tyr Ser Asp Ala Thr Gly Arg Arg Gly Met Asp Lys
  65                  70                  75                  80
 Asn Ile Gly Glu Gln Leu Asn Lys Ala Tyr Glu Ala Phe Arg Gln Ala
                  85                  90                  95    
 Cys Met Asp Arg Asp Ser Ala Val Lys Glu Leu Gln Gln Lys Ser His
             100                 105                 110        
 Asp Thr Phe His Tyr Met Glu Asp Ala Ser Val Leu Val Leu Asp Leu
         115                 120                 125            
 Pro Asp Thr Gly Val Leu Val Leu Asp Phe Pro Ala Ser Arg Thr Thr
     130                 135                 140                
 Glu Asn Tyr Glu Gln Arg Ile Arg Glu Gln Gln Glu Gln Leu Ser Leu
 145                 150                 155                 160
 Gln Gln Thr Ile Ile Asp Lys Leu Lys Ser Gln Leu Leu Leu Val Asn
                 165                 170                 175    
 Ser Thr Gln Asp Asn Asn Tyr Gly Cys Val Pro Leu Leu Glu Asp Ser
             180                 185                 190        
 Glu Thr Arg Lys Asn Asn Leu Thr Leu Asp Gln Pro Gln Asp Lys Val
         195                 200                 205            
 Ile Ser Gly Ile Ala Arg Glu Lys Leu Pro Lys Ala Val Asn Leu Ile
     210                 215                 220                
 Ser Ser Gly Gly Asn Ile Glu Lys Thr Phe Trp Asp Leu Lys Glu Glu
 225                 230                 235                 240
 Phe His Lys Ile Cys Met Leu Ala Lys Ala Gln Lys Asp His Leu Ser
                 245                 250                 255    
 Lys Leu Asn Ile Pro Asp Thr Ala Thr Glu Thr Gln Cys Ser Val Pro
             260                 265                 270        
 Ile Gln Cys Thr Asp Lys Thr Asp Lys Gln Glu Ala Leu Phe Lys Pro
         275                 280                 285            
 Gln Ala Lys Asp Asp Ile Asn Arg Gly Ala Pro Ser Ile Thr Ser Val
     290                 295                 300                
 Thr Pro Arg Gly Leu Cys Arg Asp Glu Glu Asp Thr Ser Phe Glu Ser
 305                 310                 315                 320
 Leu Ser Lys Phe Asn Val Lys Phe Pro Pro Met Asp Asn Asp Ser Thr
                 325                 330                 335    
 Phe Leu His Ser Thr Pro Glu Arg Pro Gly Ile Leu Ser Pro Ala Thr
             340                 345                 350        
 Ser Glu Ala Val Cys Gln Glu Lys Phe Asn Met Glu Phe Arg Asp Asn
         355                 360                 365            
 Pro Gly Asn Phe Val Lys Thr Glu Glu Thr Leu Phe Glu Ile Gln Gly
     370                 375                 380                
 Ile Asp Pro Ile Ala Ser Ala Ile Gln Asn Leu Lys Thr Thr Asp Lys
 385                 390                 395                 400
 Thr Lys Pro Ser Asn Leu Val Asn Thr Cys Ile Arg Thr Thr Leu Asp
                 405                 410                 415    
 Arg Ala Ala Cys Leu Pro Pro Gly Asp His Asn Ala Leu Tyr Val Asn
             420                 425                 430        
 Ser Phe Pro Leu Leu Asp Pro Ser Asp Ala Pro Phe Pro Ser Leu Asp
         435                 440                 445            
 Ser Pro Gly Lys Ala Ile Arg Gly Pro Gln Gln Pro Ile Trp Lys Pro
     450                 455                 460                
 Phe Pro Asn Gln Asp Ser Asp Ser Val Val Leu Ser Gly Thr Asp Ser
 465                 470                 475                 480
 Glu Leu His Ile Pro Arg Val Cys Glu Phe Cys Gln Ala Val Phe Pro
                 485                 490                 495    
 Pro Ser Ile Thr Ser Arg Gly Asp Phe Leu Arg His Leu Asn Ser His
             500                 505                 510        
 Phe Asn Gly Glu Thr
         515        



      <210> 1515
      <211> 245
      <212> PRT
      <213> Homo sapiens


      <400> 1515
 Met Lys Leu Val Leu Phe Leu Ser Leu Leu Lys Thr Gly Thr Leu Gly
   1               5                  10                  15    
 Gln Arg Asp Asp Gln Glu Leu Gly Glu Ala Cys Ser Arg Asp Gln Pro
              20                  25                  30        
 His Pro Val His Ala Pro Glu Lys Val Ser Ala Pro Asp Ile Leu Lys
          35                  40                  45            
 Pro Leu Asn Gln Glu Asp Pro Lys Cys Ser Thr Asn Pro Ile Leu Lys
      50                  55                  60                
 Gln Gln Asn Leu Pro Ser Ser Pro Ala Pro Ser Thr Ile Phe Ser Gly
  65                  70                  75                  80
 Gly Phe Arg His His Lys Asp Lys Thr Glu Val Ser Ile Val Lys Val
                  85                  90                  95    
 Lys Asn Leu Arg Gln Thr Ile Ala Met Lys Thr Arg Tyr Gln Asn Ile
             100                 105                 110        
 Asn Ala Trp Leu Lys Trp Ile Lys Tyr Ser Ile Arg Thr Leu Asn Lys
         115                 120                 125            
 Ser Asp Cys Tyr Ala Cys Ala His Gly Arg Pro Glu Ala Gln Leu Val
     130                 135                 140                
 Pro Phe Pro Leu Gly Gln Ser Ser Asn Arg Gln Asp Val Asp Cys Ile
 145                 150                 155                 160
 Ile Asp Phe Leu Ser Asn Pro Asp Cys Ala Asn Gly Phe Asn Lys Ser
                 165                 170                 175    
 Gln Ala Glu Phe Trp Val Ala Leu Leu Gly Gln Asn Leu Leu Val Asp
             180                 185                 190        
 Ser Ile Cys Cys Ile Gln Leu Val Thr Cys Ser Lys Ala Leu Phe Trp
         195                 200                 205            
 Leu Gln Arg Glu Gln Asn Gln Glu Pro Cys Gln Gly Asp Gly Gly Gly
     210                 215                 220                
 Ala Met Ser Arg Leu Gly Arg Asn Ala Phe Asp Gly Trp Thr Cys Ser
 225                 230                 235                 240
 Ala Leu Leu Ser Leu
                 245



      <210> 1516
      <211> 488
      <212> PRT
      <213> Homo sapiens


      <400> 1516
 Met Gly Phe Arg His Val Gly Gln Ala Gly Leu Glu Leu Leu Thr Ser
   1               5                  10                  15    
 Gly Leu Gly Leu Val Thr Ala Ser Gly Tyr Cys Thr Ile Ser Trp Gly
              20                  25                  30        
 Ser Pro Cys Thr Cys Ala Phe Gly Asn Gly Pro Ile Asp Gly His Ser
          35                  40                  45            
 Leu Ser Ile Ile Leu Glu Met Gly Leu Cys Thr Met Lys Thr Lys Gln
      50                  55                  60                
 Glu Phe Gln Asp Trp Thr Lys Arg Ser Val Glu Leu Glu Gly Gly Asn
  65                  70                  75                  80
 Ala Ser Ser Glu Leu Gln Ser Phe Gln Gly His His Asn Lys Glu Gly
                  85                  90                  95    
 Leu Arg Asn Cys Arg Ser Gln Glu Glu Pro Glu Glu Met Leu Pro Thr
             100                 105                 110        
 Ile Met Trp Asn Pro Gly Arg Asp Pro Val Glu Asp Ser Glu Ser Gly
         115                 120                 125            
 Val Tyr Met Arg Phe Met Arg Ser His Lys Cys Tyr Asp Ile Val Pro
     130                 135                 140                
 Thr Ser Ser Lys Leu Val Val Phe Asp Thr Thr Leu Gln Val Lys Lys
 145                 150                 155                 160
 Ala Phe Phe Ala Leu Val Ala Asn Gly Val Arg Ala Ala Pro Leu Trp
                 165                 170                 175    
 Glu Ser Lys Lys Gln Ser Phe Val Glu Leu Tyr Leu Gln Glu Thr Phe
             180                 185                 190        
 Lys Pro Leu Val Asn Ile Ser Pro Asp Ala Ser Leu Phe Asp Ala Val
         195                 200                 205            
 Tyr Ser Leu Ile Lys Asn Lys Ile His Arg Leu Pro Val Ile Asp Pro
     210                 215                 220                
 Ile Ser Gly Asn Ala Leu Tyr Ile Leu Thr His Lys Arg Ile Leu Lys
 225                 230                 235                 240
 Phe Leu Gln Leu Phe Met Ser Asp Met Pro Lys Pro Ala Phe Met Lys
                 245                 250                 255    
 Gln Asn Leu Asp Glu Leu Gly Ile Gly Thr Tyr His Asn Ile Ala Phe
             260                 265                 270        
 Ile His Pro Asp Thr Pro Ile Ile Lys Ala Leu Asn Ile Phe Val Glu
         275                 280                 285            
 Arg Arg Ile Ser Ala Leu Pro Val Val Asp Glu Ser Gly Lys Val Val
     290                 295                 300                
 Asp Ile Tyr Ser Lys Phe Asp Val Ile Asn Leu Ala Ala Glu Lys Thr
 305                 310                 315                 320
 Tyr Asn Asn Leu Asp Ile Thr Val Thr Gln Ala Leu Gln His Arg Ser
                 325                 330                 335    
 Gln Tyr Phe Glu Gly Val Val Lys Cys Asn Lys Leu Glu Ile Leu Glu
             340                 345                 350        
 Thr Ile Val Asp Arg Ile Val Arg Ala Glu Val His Arg Leu Val Val
         355                 360                 365            
 Val Asn Glu Ala Asp Ser Ile Val Gly Ile Ile Ser Leu Ser Asp Ile
     370                 375                 380                
 Leu Gln Ala Leu Ile Leu Thr Pro Ala Ala Pro Val Lys Tyr Glu Gln
 385                 390                 395                 400
 Pro Ser Leu Cys Gln Gly His Met Asp Pro Met Trp Glu Gln Thr Ala
                 405                 410                 415    
 Cys Pro Leu Asn Ser Gln Asn Pro Ile Leu Asn Glu Phe Thr Gly Met
             420                 425                 430        
 Glu Gln Val Met Trp His Lys Val Ser Ala Arg Tyr Val Gln Ile Thr
         435                 440                 445            
 Val Pro Tyr Val Arg Ile Gln Gln Tyr Val Thr Ala Ala Ala Gly Ala
     450                 455                 460                
 His Ala Cys Glu Thr Thr Pro Ser Leu Asn Val Glu Val Phe Glu Pro
 465                 470                 475                 480
 Phe Thr Lys Ser Val Cys Phe Leu
                 485            



      <210> 1517
      <211> 1123
      <212> PRT
      <213> Homo sapiens


      <400> 1517
 Met Leu Gln Gln Leu Leu Ile Thr Leu Pro Thr Glu Ala Ser Thr Trp
   1               5                  10                  15    
 Val Lys Leu Arg His Pro Lys Ala Ala Thr Glu Arg Val Ala Leu Trp
              20                  25                  30        
 Glu Asp Val Thr Lys Met Phe Lys Ala Glu Ala Leu Leu Ser Gln Asp
          35                  40                  45            
 Ala Asp Glu Thr Gln Gly Glu Ser Leu Glu Ser Arg Val Thr Leu Gly
      50                  55                  60                
 Ser Leu Thr Ala Glu Ser Gln Glu Leu Leu Thr Phe Lys Asp Val Ser
  65                  70                  75                  80
 Val Asp Phe Thr Gln Glu Glu Trp Gly Gln Leu Ala Pro Ala His Arg
                  85                  90                  95    
 Asn Leu Tyr Arg Glu Val Met Leu Glu Asn Tyr Gly Asn Leu Val Ser
             100                 105                 110        
 Val Gly Cys Gln Leu Ser Lys Pro Gly Val Ile Ser Gln Leu Glu Lys
         115                 120                 125            
 Gly Glu Glu Pro Trp Leu Met Glu Arg Asp Ile Ser Gly Val Pro Ser
     130                 135                 140                
 Ser Asp Leu Lys Ser Lys Thr Lys Thr Lys Glu Ser Ala Leu Gln Asn
 145                 150                 155                 160
 Asp Ile Ser Trp Glu Glu Leu His Cys Gly Leu Met Met Glu Arg Phe
                 165                 170                 175    
 Thr Lys Gly Ser Ser Met Tyr Ser Thr Leu Gly Arg Ile Ser Lys Cys
             180                 185                 190        
 Asn Lys Leu Glu Ser Gln Gln Glu Asn Gln Arg Met Gly Lys Gly Gln
         195                 200                 205            
 Ile Pro Leu Met Cys Lys Lys Thr Phe Thr Gln Glu Arg Gly Gln Glu
     210                 215                 220                
 Ser Asn Arg Phe Glu Lys Arg Ile Asn Val Lys Ser Glu Val Met Pro
 225                 230                 235                 240
 Gly Pro Ile Gly Leu Pro Arg Lys Arg Asp Arg Lys Tyr Asp Thr Pro
                 245                 250                 255    
 Gly Lys Arg Ser Arg Tyr Asn Ile Asp Leu Val Asn His Ser Arg Ser
             260                 265                 270        
 Tyr Thr Lys Met Lys Thr Phe Glu Cys Asn Ile Cys Glu Lys Ile Phe
         275                 280                 285            
 Lys Gln Leu Ile His Leu Thr Glu His Met Arg Ile His Thr Gly Glu
     290                 295                 300                
 Lys Pro Phe Arg Cys Lys Glu Cys Gly Lys Ala Phe Ser Gln Ser Ser
 305                 310                 315                 320
 Ser Leu Ile Pro His Gln Arg Ile His Thr Gly Glu Lys Pro Tyr Glu
                 325                 330                 335    
 Cys Lys Glu Cys Gly Lys Thr Phe Arg His Pro Ser Ser Leu Thr Gln
             340                 345                 350        
 His Val Arg Ile His Thr Gly Glu Lys Pro Tyr Glu Cys Arg Val Cys
         355                 360                 365            
 Glu Lys Ala Phe Ser Gln Ser Ile Gly Leu Ile Gln His Leu Arg Thr
     370                 375                 380                
 His Val Arg Glu Lys Pro Phe Thr Cys Lys Asp Cys Gly Lys Ala Phe
 385                 390                 395                 400
 Phe Gln Ile Arg His Leu Arg Gln His Glu Ile Ile His Thr Gly Val
                 405                 410                 415    
 Lys Pro Tyr Ile Cys Asn Val Cys Ser Lys Thr Phe Ser His Ser Thr
             420                 425                 430        
 Tyr Leu Thr Gln His Gln Arg Thr His Thr Gly Glu Arg Pro Tyr Lys
         435                 440                 445            
 Cys Lys Glu Cys Gly Lys Ala Phe Ser Gln Arg Ile His Leu Ser Ile
     450                 455                 460                
 His Gln Arg Val His Thr Gly Val Lys Pro Tyr Glu Cys Ser His Cys
 465                 470                 475                 480
 Gly Lys Ala Phe Arg His Asp Ser Ser Phe Ala Lys His Gln Arg Ile
                 485                 490                 495    
 His Thr Gly Glu Lys Pro Tyr Asp Cys Asn Glu Cys Gly Lys Ala Phe
             500                 505                 510        
 Ser Cys Ser Ser Ser Leu Ile Arg His Cys Lys Thr His Leu Arg Asn
         515                 520                 525            
 Thr Phe Ser Asn Val His Thr Thr Leu Asp Leu Lys Tyr Ala Leu Tyr
     530                 535                 540                
 Gln Val Glu Val Ser Leu Lys Ile Ala Pro Arg Thr Thr His Gln Glu
 545                 550                 555                 560
 Ala His Gln Arg Gly Pro Glu Lys Glu Val Asp Lys Ser Ser Lys Ala
                 565                 570                 575    
 Gly Ile Met Pro Gln Gln Leu Leu Ile Thr Leu Pro Thr Glu Ala Ser
             580                 585                 590        
 Thr Trp Val Lys Leu Gln His Pro Lys Lys Ala Val Glu Gly Ala Pro
         595                 600                 605            
 Leu Trp Glu Asp Val Thr Lys Met Phe Glu Gly Glu Ala Leu Leu Ser
     610                 615                 620                
 Gln Asp Ala Glu Asp Val Lys Thr Gln Arg Glu Ser Leu Glu Asp Glu
 625                 630                 635                 640
 Val Thr Pro Gly Leu Pro Thr Ala Glu Ser Gln Ile Arg Asp Pro Asp
                 645                 650                 655    
 Arg Leu Gln Phe Gln Thr Val Leu Leu Ile Arg Phe Gly Asp Gln Arg
             660                 665                 670        
 Ile Ser Lys Gln Ile Gln Arg Arg Leu Leu Ile Lys Glu Glu Trp Gly
         675                 680                 685            
 Gln Leu Ala Pro Ala His Gln Asn Leu Tyr Arg Glu Val Met Leu Glu
     690                 695                 700                
 Asn Tyr Ser Asn Leu Val Ser Val Gly Tyr Gln Leu Ser Lys Pro Ser
 705                 710                 715                 720
 Val Ile Ser Gln Leu Glu Lys Gly Glu Glu Pro Trp Met Ala Glu Lys
                 725                 730                 735    
 Glu Gly Pro Gly Asp Pro Ser Ser Asp Leu Lys Ser Lys Ile Glu Thr
             740                 745                 750        
 Ile Glu Ser Thr Ala Lys Ser Thr Ile Ser Gln Glu Arg Leu Tyr His
         755                 760                 765            
 Gly Ile Met Met Glu Ser Phe Met Arg Asp Asp Ile Ile Tyr Ser Thr
     770                 775                 780                
 Leu Arg Lys Val Ser Thr Tyr Asp Asp Val Leu Glu Arg His Gln Glu
 785                 790                 795                 800
 Thr Cys Met Arg Asp Val Arg Gln Ala Ile Leu Thr His Lys Lys Arg
                 805                 810                 815    
 Val Gln Glu Thr Asn Lys Phe Gly Glu Asn Ile Ile Val His Ser Asn
             820                 825                 830        
 Val Ile Ile Glu Gln Arg His His Lys Tyr Asp Thr Pro Thr Lys Arg
         835                 840                 845            
 Asn Thr Tyr Lys Leu Asp Leu Ile Asn His Pro Thr Ser Tyr Ile Arg
     850                 855                 860                
 Thr Lys Thr Tyr Glu Cys Asn Ile Cys Glu Lys Ile Phe Lys Gln Pro
 865                 870                 875                 880
 Ile His Leu Thr Glu His Met Arg Ile His Thr Gly Glu Lys Pro Phe
                 885                 890                 895    
 Arg Cys Lys Glu Cys Gly Arg Ala Phe Ser Gln Ser Ala Ser Leu Ser
             900                 905                 910        
 Thr His Gln Arg Ile His Thr Gly Glu Lys Pro Phe Glu Cys Glu Glu
         915                 920                 925            
 Cys Gly Lys Ala Phe Arg His Arg Ser Ser Leu Asn Gln His His Arg
     930                 935                 940                
 Thr His Thr Gly Glu Lys Pro Tyr Val Cys Asp Lys Cys Gln Lys Ala
 945                 950                 955                 960
 Phe Ser Gln Asn Ile Ser Leu Val Gln His Leu Arg Thr His Ser Gly
                 965                 970                 975    
 Glu Lys Pro Phe Thr Cys Asn Glu Cys Gly Lys Thr Phe Arg Gln Ile
             980                 985                 990        
 Arg His Leu Ser Glu His Ile Arg Ile His Thr Gly Glu Lys Pro Tyr
         995                1000                1005            
 Ala Cys Thr Ala Cys Cys Lys Thr Phe Ser His Arg Ala Tyr Leu Thr
    1010                1015                1020                
 His His Gln Arg Ile His Thr Gly Glu Arg Pro Tyr Lys Cys Lys Glu
1025                1030                1035                1040
 Cys Gly Lys Ala Phe Arg Gln Arg Ile His Leu Ser Asn His Lys Thr
                1045                1050                1055    
 Val His Thr Gly Val Lys Ala Tyr Glu Cys Asn Arg Cys Gly Lys Ala
            1060                1065                1070        
 Tyr Arg His Asp Ser Ser Phe Lys Lys His Gln Arg His His Thr Gly
        1075                1080                1085            
 Glu Lys Pro Tyr Glu Cys Asn Glu Cys Gly Lys Ala Phe Ser Tyr Asn
    1090                1095                1100                
 Ser Ser Leu Ser Arg His His Glu Ile His Arg Arg Asn Ala Phe Arg
1105                1110                1115                1120
 Asn Lys Val
            



      <210> 1518
      <211> 170
      <212> PRT
      <213> Homo sapiens


      <400> 1518
 Met Ser Arg Ser Val Ala Leu Ala Val Leu Ala Leu Leu Ser Leu Ser
   1               5                  10                  15    
 Gly Leu Glu Ala Ile Gln Arg Thr Pro Lys Ile Gln Val Tyr Ser Arg
              20                  25                  30        
 His Pro Ala Glu Asn Gly Lys Ser Asn Phe Leu Asn Cys Tyr Val Ser
          35                  40                  45            
 Gly Phe His Pro Ser Asp Ile Glu Val Asp Leu Leu Lys Asn Gly Glu
      50                  55                  60                
 Arg Ile Glu Lys Val Glu His Ser Asp Leu Ser Phe Ser Lys Asp Trp
  65                  70                  75                  80
 Ser Phe Tyr Leu Leu Tyr Tyr Thr Glu Phe Thr Pro Thr Glu Lys Asp
                  85                  90                  95    
 Glu Tyr Ala Cys Arg Val Asn His Val Thr Leu Ser Gln Pro Lys Ile
             100                 105                 110        
 Val Lys Trp Ala Phe Val Ala Ala Ser Gly Ile Phe Ser Thr Glu Arg
         115                 120                 125            
 Thr Ser Gln Glu Gly Ile Gly Leu Cys Leu Ser Arg His Val Ser Ser
     130                 135                 140                
 Ile Met Glu Asn Arg Glu Leu Ile Trp Glu Ser Ile Arg Lys Val Asp
 145                 150                 155                 160
 Asp Leu Pro Ser His Thr Val Ser Lys Leu
                 165                 170



      <210> 1519
      <211> 235
      <212> PRT
      <213> Homo sapiens


      <400> 1519
 Met Trp Asn Cys Lys Ser Asn Lys Pro Leu Tyr Phe Val Asn Cys Leu
   1               5                  10                  15    
 Val Ser Ala Thr Tyr Ile Ala Tyr Leu His Leu Pro Ser Asp Ile Asp
              20                  25                  30        
 Glu Ile Val Leu Glu Arg Asp Asn Glu Val Pro Arg Val Trp Lys Lys
          35                  40                  45            
 Asp Ser Leu Gly Ala Thr His Leu Glu Trp Glu Gly Glu Leu Met Gly
      50                  55                  60                
 Gln Met Arg Lys Glu Leu Glu Lys Gln Glu Gln Ile Lys Pro Lys Ala
  65                  70                  75                  80
 Ser Arg Arg Gln Glu Ile Thr Lys Ile Arg Ala Glu Leu Lys Glu Ile
                  85                  90                  95    
 Lys Thr Gln Lys Thr Ile Gln Glu Ile Asn Lys Ser Arg Ser Trp Phe
             100                 105                 110        
 Phe Glu Lys Asn Asn Lys Ile Glu Arg Thr Ser Leu Gln Glu Phe Asn
         115                 120                 125            
 Leu Ser Asn Leu Val Glu Ser Ile Thr Ser Ala Arg Ile Thr Thr Glu
     130                 135                 140                
 Gly Gly Gly Val Leu Ser Glu Phe Leu Tyr Asn Met Gln Gly Gln Arg
 145                 150                 155                 160
 Ser Cys Ile Gly Ser Ala Leu Leu Ser Val Leu Leu Ala Ile Leu Arg
                 165                 170                 175    
 Pro Arg Ala Thr Val Pro Glu Asp Ile Thr Asn Gln Pro Leu Pro Tyr
             180                 185                 190        
 Ser Leu Leu Ser Gln Asp Thr Met Arg Thr Ser Gln Gly Gly Leu Pro
         195                 200                 205            
 Leu Pro Ile Arg Val Gly Ala Asp Asp Gly Val Val Lys Ser Glu Ser
     210                 215                 220                
 Gly Ser Ile Cys Ser Ala Ser Gly Cys Ile Ser
 225                 230                 235



      <210> 1520
      <211> 135
      <212> PRT
      <213> Homo sapiens


      <400> 1520
 Met Arg Gln Met His Thr Val Glu Tyr Tyr Leu Ala Leu Lys Arg Lys
   1               5                  10                  15    
 Glu Ile Gln Thr His Ala Thr Thr Trp Met Lys Val Glu Gly Ile Arg
              20                  25                  30        
 Leu Ser Glu Ile Ser Gln Thr Gln Lys Asp Lys Tyr Val Leu Ala Lys
          35                  40                  45            
 Gly Ser Gly Phe Cys Cys Cys Ser Arg Gln Glu Val Pro Ser Tyr Pro
      50                  55                  60                
 Ala His Leu Leu Thr Phe Leu Ser Leu Gln Leu Thr Asp Phe Gly Cys
  65                  70                  75                  80
 Leu Ser His Pro Arg Asn Val Ser Thr Leu Arg Ala Ala Thr Val Met
                  85                  90                  95    
 Gln Pro Leu Thr Tyr Asn Arg Leu Leu Arg Lys Tyr Thr Glu Ser Glu
             100                 105                 110        
 Leu Met Arg Ser Tyr Val Leu His Phe Ile Ser Ile Ser Asp Asn Ile
         115                 120                 125            
 Ser Asp Asp Glu Met Tyr Asp
     130                 135



      <210> 1521
      <211> 741
      <212> PRT
      <213> Homo sapiens


      <400> 1521
 Met Ala Ala Leu Arg Leu Leu Ala Ser Val Leu Gly Arg Gly Val Pro
   1               5                  10                  15    
 Ala Gly Gly Ser Gly Leu Ala Leu Ser Gln Gly Cys Ala Arg Cys Phe
              20                  25                  30        
 Ala Thr Ser Pro Arg Pro Arg Ala Lys Phe Tyr Ala Asp Pro Val Glu
          35                  40                  45            
 Met Val Lys Asp Ile Ser Asp Gly Ala Thr Val Met Ile Gly Gly Phe
      50                  55                  60                
 Gly Leu Cys Gly Ile Pro Glu Asn Leu Ile Ala Ala Leu Leu Arg Thr
  65                  70                  75                  80
 Arg Val Lys Asp Leu Gln Val Val Ser Ser Asn Val Gly Val Glu Asp
                  85                  90                  95    
 Phe Gly Leu Gly Leu Leu Leu Ala Ala Arg Gln Val Arg Arg Ile Val
             100                 105                 110        
 Cys Ser Tyr Val Gly Glu Asn Thr Leu Cys Glu Ser Gln Tyr Leu Ala
         115                 120                 125            
 Gly Glu Leu Glu Leu Glu Leu Thr Pro Gln Gly Thr Leu Ala Glu Arg
     130                 135                 140                
 Ile Arg Ala Gly Gly Ala Gly Val Pro Ala Phe Tyr Thr Pro Thr Gly
 145                 150                 155                 160
 Tyr Gly Thr Leu Val Gln Glu Gly Gly Ala Pro Ile Arg Tyr Thr Pro
                 165                 170                 175    
 Asp Gly His Leu Ala Leu Met Ser Gln Pro Arg Glu Val Arg Glu Phe
             180                 185                 190        
 Asn Gly Asp His Phe Leu Leu Glu Arg Ala Ile Arg Ala Asp Phe Ala
         195                 200                 205            
 Leu Val Lys Gly Trp Lys Ala Asp Arg Ala Gly Asn Val Val Phe Arg
     210                 215                 220                
 Arg Ser Ala Arg Asn Phe Asn Val Pro Met Cys Lys Ala Ala Asp Val
 225                 230                 235                 240
 Thr Ala Val Glu Gly Gln Lys Tyr Glu Lys Arg Ile Glu Arg Leu Thr
                 245                 250                 255    
 Ile Arg Lys Glu Glu Asp Gly Asp Ala Gly Lys Glu Glu Asp Ala Arg
             260                 265                 270        
 Thr Arg Ile Ile Arg Arg Ala Ala Leu Glu Phe Glu Asp Gly Met Tyr
         275                 280                 285            
 Ala Asn Leu Gly Ile Gly Ile Pro Leu Leu Ala Ser Asn Phe Ile Ser
     290                 295                 300                
 Pro Ser Met Thr Val His Leu His Ser Glu Asn Gly Ile Leu Gly Leu
 305                 310                 315                 320
 Gly Pro Phe Pro Thr Glu Asp Glu Val Asp Ala Asp Leu Ile Asn Ala
                 325                 330                 335    
 Gly Lys Gln Thr Val Thr Val Leu Pro Gly Gly Cys Phe Phe Ala Ser
             340                 345                 350        
 Asp Asp Ser Phe Ala Met Ile Arg Gly Gly His Ile Gln Leu Thr Met
         355                 360                 365            
 Leu Gly Ala Met Gln Val Ser Lys Tyr Gly Asp Leu Ala Asn Trp Met
     370                 375                 380                
 Ile Pro Gly Lys Lys Val Lys Gly Met Gly Gly Ala Met Asp Leu Val
 385                 390                 395                 400
 Ser Ser Gln Lys Thr Arg Val Val Val Thr Met Gln His Cys Thr Lys
                 405                 410                 415    
 Asp Asn Thr Pro Lys Ile Met Glu Lys Cys Thr Met Pro Leu Thr Gly
             420                 425                 430        
 Lys Arg Cys Val Asp Arg Ile Ile Thr Glu Lys Ala Val Phe Asp Val
         435                 440                 445            
 His Arg Lys Lys Arg Leu Thr Leu Arg Glu Leu Trp Glu Gly Leu Thr
     450                 455                 460                
 Val Asp Asp Ile Lys Lys Ser Thr Gly Cys Ala Phe Ala Val Ser Pro
 465                 470                 475                 480
 Asn Leu Arg Pro Met Gln Gln Val Pro Ala Gly Ala Arg Glu Ser Cys
                 485                 490                 495    
 Leu Arg Met Gly Gly Glu Thr Val Asn Ala Leu Leu Leu Gly Cys Ala
             500                 505                 510        
 Gln Gln Asn Lys His Ser Leu Asn Leu Ala Asp Ala Thr Thr Ser Cys
         515                 520                 525            
 Leu Gly Asp Lys Phe Asp Ile His Thr Pro Glu Thr Ser Thr Leu Leu
     530                 535                 540                
 Asp Leu Pro Arg Pro Arg Gln Arg Asp Arg Cys Cys Val Cys Cys Arg
 545                 550                 555                 560
 Ala Ala Ala Arg His Ser Val Asp Pro Gly Leu Ala Gly Leu Leu Gly
                 565                 570                 575    
 Gln Arg Ala Pro Arg Ser Gln Gln Pro Phe Val Val Thr Phe Phe Arg
             580                 585                 590        
 Ala Ser Pro Ser Pro Ile Arg Thr Pro Arg Ala Val Arg Pro Leu Arg
         595                 600                 605            
 Arg Arg Gln Pro Lys Lys Ser Asn Glu Leu Pro Gln Ala Asn Arg Leu
     610                 615                 620                
 Pro Gly Ile Phe Asp Asp Val Arg Gly Ser His Gly Arg Gln Val Cys
 625                 630                 635                 640
 Arg Arg His Glu Leu Tyr Val Ser Phe Gln Asp Leu Gly Trp Leu Asp
                 645                 650                 655    
 Trp Val Ile Ala Pro Gln Gly Tyr Ser Ala Tyr Tyr Cys Glu Gly Glu
             660                 665                 670        
 Cys Ser Phe Pro Leu Asp Ser Cys Met Asn Ala Thr Asn His Ala Ile
         675                 680                 685            
 Leu Gln Ser Leu Val His Leu Met Lys Pro Asn Ala Val Pro Lys Ala
     690                 695                 700                
 Cys Cys Ala Pro Thr Lys Leu Ser Ala Thr Ser Val Leu Tyr Tyr Asp
 705                 710                 715                 720
 Ser Ser Asn Asn Val Ile Leu Arg Lys His Arg Asn Met Val Val Lys
                 725                 730                 735    
 Ala Cys Gly Cys His
             740    



      <210> 1522
      <211> 255
      <212> PRT
      <213> Homo sapiens


      <400> 1522
 Met Leu Cys Arg Leu Gly Gly Arg Trp Leu Arg Pro Leu Pro Ala Leu
   1               5                  10                  15    
 Gln Leu Trp Ala Arg Asp Leu Pro Leu Ala Pro Val Pro Thr Ser Gly
              20                  25                  30        
 Ala Lys Arg Pro Thr Leu Pro Val Trp Ala Val Ala Pro Val Ser Ala
          35                  40                  45            
 Val His Ala Asn Gly Trp Tyr Glu Ala Leu Ala Ala Ser Ser Pro Val
      50                  55                  60                
 Arg Val Ala Glu Glu Val Leu Leu Gly Val His Ala Ala Thr Gly Leu
  65                  70                  75                  80
 Pro Trp Trp Gly Ser Ile Leu Leu Ser Thr Val Ala Leu Arg Gly Ala
                  85                  90                  95    
 Val Thr Leu Pro Leu Ala Ala Tyr Gln His Tyr Ile Leu Ala Lys Val
             100                 105                 110        
 Val Ser Met Gly Lys Lys Asn Arg Lys Gln Asn Arg Asn Gly Ile Ser
         115                 120                 125            
 Ser Asn Ile Lys Ala Val Glu Asn Leu Gln Pro Glu Ile Lys Thr Ile
     130                 135                 140                
 Ala Arg His Leu Asn Gln Glu Val Ala Val Arg Ala Asn Gln Leu Gly
 145                 150                 155                 160
 Trp Ser Lys Arg Asp Ala Arg Leu Ala Ala Leu Asp Ser His Ser Thr
                 165                 170                 175    
 Asn Pro Ile Val Asn Cys Thr Glu Glu Gly Lys Glu Asn Ala Phe Leu
             180                 185                 190        
 Thr Thr Leu Arg Asn Trp Leu Leu Gly Asn Ile Trp Lys Ile Asp Asp
         195                 200                 205            
 Cys Met Gly Lys Ile Arg Cys Arg Glu Ala Lys Phe Ala Ile Ile Ser
     210                 215                 220                
 Ala Thr Leu Pro Ala Phe Tyr Leu Gln Tyr Val Ser Ser Trp Thr Gly
 225                 230                 235                 240
 Leu Leu Val Gly Lys Lys Leu Cys Ser Ile Val Glu Glu Gly Arg
                 245                 250                 255



      <210> 1523
      <211> 861
      <212> PRT
      <213> Homo sapiens


      <400> 1523
 Met Arg Leu Leu Arg Arg Trp Ala Phe Ala Ala Leu Leu Leu Ser Leu
   1               5                  10                  15    
 Leu Pro Thr Pro Gly Leu Gly Thr Gln Gly Pro Ala Gly Ala Leu Arg
              20                  25                  30        
 Trp Gly Gly Leu Pro Gln Leu Gly Gly Pro Gly Ala Pro Glu Val Thr
          35                  40                  45            
 Glu Pro Ser Arg Leu Val Arg Glu Ser Ser Gly Gly Glu Val Arg Lys
      50                  55                  60                
 Gln Gln Leu Asp Thr Arg Val Arg Gln Glu Pro Pro Gly Gly Pro Pro
  65                  70                  75                  80
 Pro Gly Pro Gln Gly Gly Gly Val Ser Leu Arg Glu Gly Ile Pro Glu
                  85                  90                  95    
 Arg Cys Pro Gln Pro Val His Leu Ala Gln Val Ser Phe Val Ile Pro
             100                 105                 110        
 Ala Phe Asn Ser Asn Phe Thr Leu Asp Leu Glu Leu Asn His His Leu
         115                 120                 125            
 Leu Ser Ser Gln Tyr Val Glu Arg His Phe Ser Arg Glu Gly Thr Thr
     130                 135                 140                
 Gln His Ser Thr Gly Ala Gly Asp His Cys Tyr Tyr Gln Gly Lys Leu
 145                 150                 155                 160
 Arg Gly Asn Pro His Ser Phe Ala Ala Leu Ser Thr Cys Gln Gly Leu
                 165                 170                 175    
 His Gly Val Phe Ser Asp Gly Asn Leu Thr Tyr Ile Val Glu Pro Gln
             180                 185                 190        
 Glu Val Ala Gly Pro Trp Gly Ala Pro Gln Ile Pro Ser Asp Ala Gly
         195                 200                 205            
 Asn Gln Val Arg Arg Gly His Pro Thr Val His Ser Glu Thr Lys Tyr
     210                 215                 220                
 Val Glu Leu Ile Val Ile Asn Asp His Gln Leu Phe Glu Gln Met Arg
 225                 230                 235                 240
 Gln Ser Val Val Leu Thr Ser Asn Phe Ala Lys Ser Val Val Asn Leu
                 245                 250                 255    
 Ala Asp Val Ile Tyr Lys Glu Gln Leu Asn Thr Arg Ile Val Leu Val
             260                 265                 270        
 Ala Met Glu Thr Trp Ala Asp Gly Asp Lys Ile Gln Val Gln Asp Asp
         275                 280                 285            
 Leu Leu Glu Thr Leu Ala Arg Leu Met Val Tyr Arg Arg Glu Gly Leu
     290                 295                 300                
 Pro Glu Pro Ser Asp Ala Thr His Leu Phe Ser Gly Arg Thr Phe Gln
 305                 310                 315                 320
 Ser Thr Ser Ser Gly Ala Ala Tyr Val Gly Gly Ile Cys Ser Leu Ser
                 325                 330                 335    
 His Gly Gly Gly Val Asn Glu Tyr Gly Asn Met Gly Ala Met Ala Val
             340                 345                 350        
 Thr Leu Ala Gln Thr Leu Gly Gln Asn Leu Gly Met Met Trp Asn Lys
         355                 360                 365            
 His Arg Ser Ser Ala Gly Asp Cys Lys Cys Pro Asp Ile Trp Leu Gly
     370                 375                 380                
 Cys Ile Met Glu Asp Thr Gly Phe Tyr Leu Pro Arg Lys Phe Ser Arg
 385                 390                 395                 400
 Cys Ser Ile Asp Glu Tyr Asn Gln Phe Leu Gln Glu Gly Gly Gly Ser
                 405                 410                 415    
 Cys Leu Phe Asn Lys Pro Leu Lys Leu Leu Asp Pro Pro Glu Cys Gly
             420                 425                 430        
 Asn Gly Phe Val Glu Ala Gly Glu Glu Cys Asp Cys Gly Ser Val Gln
         435                 440                 445            
 Glu Cys Ser Arg Ala Gly Gly Asn Cys Cys Lys Lys Cys Thr Leu Thr
     450                 455                 460                
 His Asp Ala Met Cys Ser Asp Gly Leu Cys Cys Arg Arg Cys Lys Tyr
 465                 470                 475                 480
 Glu Pro Arg Gly Val Ser Cys Arg Glu Ala Val Asn Glu Cys Asp Ile
                 485                 490                 495    
 Ala Glu Thr Cys Thr Gly Asp Ser Ser Gln Cys Pro Pro Asn Leu His
             500                 505                 510        
 Lys Leu Asp Gly Tyr Tyr Cys Asp His Glu Gln Gly Arg Cys Tyr Gly
         515                 520                 525            
 Gly Arg Cys Lys Thr Arg Asp Arg Gln Cys Gln Val Leu Trp Gly His
     530                 535                 540                
 Ala Ala Ala Asp Arg Phe Cys Tyr Glu Lys Leu Asn Val Glu Gly Thr
 545                 550                 555                 560
 Glu Arg Gly Ser Cys Gly Arg Lys Gly Ser Gly Trp Val Gln Cys Ser
                 565                 570                 575    
 Lys Gln Asp Val Leu Cys Gly Phe Leu Leu Cys Val Asn Ile Ser Gly
             580                 585                 590        
 Ala Pro Arg Leu Gly Asp Leu Val Gly Asp Ile Ser Ser Val Thr Phe
         595                 600                 605            
 Tyr His Gln Gly Lys Glu Leu Asp Cys Arg Gly Gly His Val Gln Leu
     610                 615                 620                
 Ala Asp Gly Ser Asp Leu Ser Tyr Val Glu Asp Gly Thr Ala Cys Gly
 625                 630                 635                 640
 Pro Asn Met Leu Cys Leu Asp His Arg Cys Leu Pro Ala Ser Ala Phe
                 645                 650                 655    
 Asn Phe Ser Thr Cys Pro Gly Ser Gly Glu Arg Arg Ile Cys Ser His
             660                 665                 670        
 His Gly Val Cys Ser Asn Glu Gly Lys Cys Ile Cys Gln Pro Asp Trp
         675                 680                 685            
 Thr Gly Lys Asp Cys Ser Ile His Asn Pro Leu Pro Thr Ser Pro Pro
     690                 695                 700                
 Thr Gly Glu Thr Glu Arg Tyr Lys Gly Pro Ser Gly Thr Asn Ile Ile
 705                 710                 715                 720
 Ile Gly Ser Ile Ala Gly Ala Val Leu Val Ala Ala Ile Val Leu Gly
                 725                 730                 735    
 Gly Thr Gly Trp Gly Phe Lys Asn Ile Arg Arg Gly Arg Val Leu Gly
             740                 745                 750        
 Pro Gly Glu Asp Gln Gln Glu Arg Glu Ala Ala Pro Ala Gln Gly Phe
         755                 760                 765            
 Met Leu Arg Lys Ile Leu Glu Asp Phe Gln Leu Ser Pro Glu Thr Gln
     770                 775                 780                
 Cys Leu Arg Pro Arg Leu Phe Arg Pro Leu Val Leu Lys Ala Lys Asn
 785                 790                 795                 800
 Pro Arg His Phe Phe His Val Glu Leu Asp Pro Ser Arg Pro Arg Lys
                 805                 810                 815    
 His His Val Ala Val Ile Ser Ala Ala Pro Ala Arg Asn Thr Phe Tyr
             820                 825                 830        
 Asp Ser Ile Val Gly Gly Leu Pro Ala His Arg Cys Leu Ser Val Phe
         835                 840                 845            
 Leu Arg Thr Ser Ser His Leu His Leu Pro Thr Arg Val
     850                 855                 860    



      <210> 1524
      <211> 579
      <212> PRT
      <213> Homo sapiens


      <400> 1524
 Met Gly Ala Tyr Val Leu Glu Gly Val Leu Gly Val Val Leu Gly His
   1               5                  10                  15    
 Ala Gly Phe Thr Leu Pro Arg Ala Gly Ser His Gln Val Gly Ala Ala
              20                  25                  30        
 Gln Phe Leu Val His Ile Gly Gly Arg Pro Ser Gln Pro Val Ala Ser
          35                  40                  45            
 Asp Leu Asp Val Cys Gly Arg Gln Gln His Thr Leu Val Thr Cys Ala
      50                  55                  60                
 Ala Gly Gly Phe Ala Thr Phe Ser Ser Cys Phe Pro Gly Leu Cys Glu
  65                  70                  75                  80
 Gly Lys Pro Ala Ala Leu Leu Pro Met Ser Leu Ser Gln Pro Cys Leu
                  85                  90                  95    
 Pro Val Pro Ser Val Gly Leu Thr Arg Ile Leu Pro His Leu Tyr Leu
             100                 105                 110        
 Gly Ser Gln Lys Asp Val Leu Asn Lys Asp Leu Met Thr Gln Asn Gly
         115                 120                 125            
 Ile Ser Tyr Val Leu Asn Ala Ser Asn Ser Cys Pro Lys Pro Asp Phe
     130                 135                 140                
 Ile Cys Glu Ser Arg Phe Met Arg Val Pro Ile Asn Asp Asn Tyr Cys
 145                 150                 155                 160
 Glu Lys Leu Leu Pro Trp Leu Asp Lys Ser Ile Glu Phe Ile Asp Lys
                 165                 170                 175    
 Ala Lys Leu Ser Ser Cys Gln Val Ile Val His Cys Leu Ala Gly Ile
             180                 185                 190        
 Ser Arg Ser Ala Thr Ile Ala Ile Ala Tyr Ile Met Lys Thr Met Gly
         195                 200                 205            
 Met Ser Ser Asp Asp Ala Tyr Arg Phe Val Lys Asp Arg Arg Pro Ser
     210                 215                 220                
 Ile Ser Pro Asn Phe Asn Phe Leu Gly Gln Leu Leu Glu Tyr Glu Arg
 225                 230                 235                 240
 Ser Leu Lys Leu Leu Ala Ala Leu Gln Gly Asp Pro Gly Thr Pro Ser
                 245                 250                 255    
 Gly Thr Pro Glu Pro Pro Pro Ser Pro Ala Ala Gly Ala Pro Leu Pro
             260                 265                 270        
 Arg Leu Pro Pro Pro Thr Ser Glu Ser Ala Ala Thr Gly Asn Ala Ala
         275                 280                 285            
 Ala Arg Glu Gly Gly Leu Ser Ala Gly Gly Glu Pro Pro Ala Pro Pro
     290                 295                 300                
 Thr Pro Pro Ala Thr Ser Ala Leu Gln Gln Gly Leu Arg Gly Leu His
 305                 310                 315                 320
 Leu Ser Ser Asp Arg Leu Gln Asp Thr Asn Arg Leu Lys Arg Ser Phe
                 325                 330                 335    
 Ser Leu Asp Ile Lys Ser Ala Tyr Ala Pro Ser Met Arg Pro Asp Gly
             340                 345                 350        
 Pro Gly Pro Pro Asp Pro Gly Glu Ala Pro Lys Leu Cys Lys Leu Asp
         355                 360                 365            
 Ser Pro Ser Gly Ala Ala Leu Gly Leu Ser Ser Pro Ile Pro Asp Ser
     370                 375                 380                
 Pro Asp Ala Ala Pro Asp Ala Arg Pro Arg Pro Arg Arg Arg Pro Arg
 385                 390                 395                 400
 Pro Pro Ala Gly Ser Pro Ala Arg Ser Pro Ala His Ser Leu Gly Leu
                 405                 410                 415    
 Asn Phe Gly Asp Ala Ala Arg Gln Thr Pro Arg His Gly Leu Ser Ala
             420                 425                 430        
 Leu Ser Ala Pro Gly Leu Pro Gly Pro Gly Gln Pro Ala Gly Pro Gly
         435                 440                 445            
 Ala Trp Ala Pro Pro Leu Asp Ser Pro Gly Thr Pro Ser Pro Asp Gly
     450                 455                 460                
 Pro Trp Cys Phe Ser Pro Glu Gly Ala Gln Gly Ala Gly Gly Val Leu
 465                 470                 475                 480
 Phe Ala Pro Phe Gly Arg Ala Gly Ala Pro Gly Pro Gly Gly Gly Ser
                 485                 490                 495    
 Asp Leu Arg Arg Arg Glu Ala Ala Arg Ala Glu Pro Arg Asp Ala Arg
             500                 505                 510        
 Thr Gly Trp Pro Glu Glu Pro Ala Pro Glu Thr Gln Phe Lys Arg Arg
         515                 520                 525            
 Ser Cys Gln Met Glu Phe Glu Glu Gly Met Gly Val Gln Ala Pro Ala
     530                 535                 540                
 Lys Pro Leu Cys Cys Trp Asp Arg Pro Ala Ser Leu Arg Glu His Cys
 545                 550                 555                 560
 Leu Lys Thr Gly Gly Met Pro Ala Pro Lys His Lys Trp Leu Leu Gly
                 565                 570                 575    
 Pro Gly Arg
            



      <210> 1525
      <211> 110
      <212> PRT
      <213> Homo sapiens


      <400> 1525
 Met Ile Val Gly Ile Phe Ala Leu Cys Trp Leu Pro Val His Ala Val
   1               5                  10                  15    
 Asn Cys Val Thr Leu Phe Gln Pro Ala Gln Gly Lys Asn Lys Pro Lys
              20                  25                  30        
 Trp Ala Met Asn Met Ala Ile Leu Leu Ser His Ala Asn Ser Val Val
          35                  40                  45            
 Asn Pro Ile Val Tyr Ala Tyr Arg Asn Arg Asp Phe Arg Tyr Thr Phe
      50                  55                  60                
 His Lys Ile Ile Ser Arg Tyr Leu Leu Cys Gln Ala Asp Val Lys Ser
  65                  70                  75                  80
 Gly Asn Ala Ser Leu Met Ile Phe Tyr Ile Lys Ile Gln Glu Ile Asp
                  85                  90                  95    
 Ala Val Leu Lys Met Thr Leu His Phe Glu Arg Leu Asn Pro
             100                 105                 110



      <210> 1526
      <211> 158
      <212> PRT
      <213> Homo sapiens


      <400> 1526
 Met Leu Thr Val Val Thr Ser Thr Phe Trp Gly Leu Pro Ile Ser Thr
   1               5                  10                  15    
 Phe Trp Gly Pro Trp Asp Gly Gly Arg Val Leu Val Gln Gly Gly Gly
              20                  25                  30        
 Val Phe Ser Asp Arg Ser Gly Ser Gly Lys Trp Ala Glu Lys Glu Leu
          35                  40                  45            
 Val Phe Met Ser Ala Gly Ile Asp Glu Arg Gly Gly Thr Thr Ser Trp
      50                  55                  60                
 Gly Thr Ser Gly Gln Pro Ser Pro Ser Tyr Asp Ser Ser Arg Gly Phe
  65                  70                  75                  80
 Thr Asp Ser Pro His Tyr Ser Asp His Leu Asn Asp Ser Arg Leu Gly
                  85                  90                  95    
 Ala His Glu Gly Leu Ser Pro Thr Pro Phe Met Asn Ser Asn Leu Met
             100                 105                 110        
 Val Phe Glu Ala Phe Gly Thr Val Asp Asn Gln Ser Ser Gln Gln Val
         115                 120                 125            
 Thr Val Glu Ser Gly Ala Val His Asp Glu Cys Ser Glu Thr Ala Lys
     130                 135                 140                
 Thr Asn Arg Lys Ala Val Thr Phe Pro Val Ala Val Asn Ile
 145                 150                 155            



      <210> 1527
      <211> 440
      <212> PRT
      <213> Homo sapiens


      <400> 1527
 Met Leu Ala Ala Leu Gly Cys Ser Arg Arg Leu Leu Gly Leu Gly Leu
   1               5                  10                  15    
 Arg Ser Gly Leu Ala Arg Gly Ala Leu Gln Pro Thr Ser Ala Leu Trp
              20                  25                  30        
 Gly Leu Leu Ser Gly Ala Asp Gln Gly Arg Ser Arg Leu Pro Leu Leu
          35                  40                  45            
 Ala Gly Arg Tyr Met Val Glu Leu Ala Ala Gly Lys Pro His His Thr
      50                  55                  60                
 Lys Phe Lys Thr Arg Gly Ser Leu Ala Asn Pro Ala Phe Pro Ile Ser
  65                  70                  75                  80
 Glu Ala Asp Leu Trp His Asn Ser Ser Arg Arg Gly Cys Phe Gly Phe
                  85                  90                  95    
 Ala Val Glu Pro Gly Leu Leu Gln Thr Pro Pro His Gln Cys Pro Arg
             100                 105                 110        
 Asn Thr Ile Cys Asn Lys Gly Glu Trp Leu Lys Ile Asn Glu Tyr Asn
         115                 120                 125            
 Lys Ile Val Glu Cys Asn Ile Ser Arg His Gly Thr Gly Pro Arg Leu
     130                 135                 140                
 Thr Met Ala Ala Ala Arg His Ser Met Leu Asp Phe Thr Leu Gly Ala
 145                 150                 155                 160
 Lys Ala Asp Gly Glu Thr Val Leu Lys Gly Leu Gln Ser Ile Phe Gln
                 165                 170                 175    
 Glu Gln Gly Met Ala Glu Ser Val His Thr Trp Gln Asp His Gly Tyr
             180                 185                 190        
 Leu Ala Thr Tyr Thr Lys Lys Asn Gly Ser Phe Ala Asn Leu Arg Ile
         195                 200                 205            
 Tyr Pro His Gly Leu Val Leu Leu Asp Leu Gln Ser Tyr Asp Gly Asp
     210                 215                 220                
 Val Gln Gly Lys Glu Glu Ile Asp Ser Ile Leu Asn Lys Val Glu Glu
 225                 230                 235                 240
 Arg Met Lys Glu Leu Ser Gln Asp Ser Thr Gly Arg Val Lys Arg Leu
                 245                 250                 255    
 Pro Pro Ile Val Arg Gly Gly Ala Ile Asp Arg Tyr Trp Leu Thr Ala
             260                 265                 270        
 Asp Gly Arg Leu Val Glu Tyr Asp Ile Asp Glu Val Phe Gly Asn Ile
         275                 280                 285            
 Leu Ile Val Ser Gly Asp Val Asn Leu Ala Glu Ser Asp Leu Ala Tyr
     290                 295                 300                
 Thr Arg Ala Ile Met Gly Ser Gly Glu Glu Asp Tyr Thr Gly Lys Asp
 305                 310                 315                 320
 Val Leu Ile Leu Gly Gly Gly Asp Gly Gly Ile Leu Cys Glu Ile Val
                 325                 330                 335    
 Lys Leu Lys Pro Lys Met Val Thr Met Val Glu Ile Asp Glu Met Val
             340                 345                 350        
 Ile Asp Gly Cys Lys Lys Tyr Met Gln Lys Thr Tyr Gly Asp Val Leu
         355                 360                 365            
 Asp Asn Leu Lys Gly Asp Cys Tyr Gln Val Leu Ile Glu Asp Cys Ile
     370                 375                 380                
 Pro Val Leu Lys Ser Leu Ile Lys Glu Met Thr Val Leu Thr Arg Leu
 385                 390                 395                 400
 Val Thr Thr Glu Trp Ser Ala Ala Ala Asp Lys Phe Thr Val Ser Thr
                 405                 410                 415    
 Thr Val Ser Ala Ser Glu Lys Asn Gln Gln Trp Glu Gly Pro Arg Gln
             420                 425                 430        
 Leu Asp Asp Thr Cys Pro Gln Gln
         435                 440



      <210> 1528
      <211> 415
      <212> PRT
      <213> Homo sapiens


      <400> 1528
 Met Arg Leu Gly Pro Arg Thr Ala Ala Leu Gly Leu Leu Leu Leu Cys
   1               5                  10                  15    
 Ala Ala Ala Ala Gly Ala Gly Lys Ala Glu Glu Leu His Tyr Pro Leu
              20                  25                  30        
 Gly Glu Arg Arg Ser Asp Tyr Asp Arg Glu Ala Leu Leu Gly Val Gln
          35                  40                  45            
 Glu Asp Val Asp Glu Tyr Val Lys Leu Gly His Glu Glu Gln Gln Lys
      50                  55                  60                
 Arg Leu Gln Ala Ile Ile Lys Lys Ile Asp Leu Asp Ser Asp Gly Phe
  65                  70                  75                  80
 Leu Thr Glu Ser Lys Asp Cys Pro Thr Arg Leu Thr Met Glu Thr Asn
                  85                  90                  95    
 Thr Asn Met Leu Ser Ser Glu Lys Val Trp Lys Ser Leu Leu Leu Ser
             100                 105                 110        
 Ile Arg Ile Asn Val Thr Cys Val Val Phe Trp Glu Ile Leu Ile Gly
         115                 120                 125            
 Glu Leu Ser Ser Trp Ile Gln Met Ser Phe Lys His Tyr Ala Met Gln
     130                 135                 140                
 Glu Ala Lys Gln Gln Phe Val Glu Tyr Asp Lys Asn Ser Asp Asp Thr
 145                 150                 155                 160
 Val Thr Trp Asp Glu Tyr Asn Ile Gln Met Tyr Asp Arg Val Ile Asp
                 165                 170                 175    
 Phe Asp Glu Asn Thr Ala Leu Asp Asp Ala Glu Glu Glu Ser Phe Arg
             180                 185                 190        
 Lys Glu Phe Ala Ile Cys Lys Lys Gln Ser Phe Cys Phe Trp Leu Leu
         195                 200                 205            
 Arg Phe Asn Val Ser Tyr Ser Tyr Phe Val Phe Phe Lys Trp Pro Leu
     210                 215                 220                
 Ile Asp Glu Glu Thr Arg Glu Val Lys Gln Phe Ala Leu Thr Pro Gln
 225                 230                 235                 240
 Leu Val Ser Gly Ile Ala Gly Ile Gln Val Trp Val Tyr Met Thr Leu
                 245                 250                 255    
 Glu Leu Asp Lys Lys Arg Phe Glu Lys Ala Asn Gln Asp Ser Gly Pro
             260                 265                 270        
 Gly Leu Ser Leu Glu Glu Phe Ile Ala Phe Glu His Pro Glu Glu Val
         275                 280                 285            
 Asp Tyr Met Thr Val Asp Leu Lys Arg Asp Arg Asn Ile Lys His Tyr
     290                 295                 300                
 Lys Tyr Trp Cys Lys His Ser Ile Arg Ser Leu Val Glu Ala Ala Asn
 305                 310                 315                 320
 Glu Asp Pro Glu Trp Ile Leu Val Glu Lys Asp Arg Phe Val Asn Asp
                 325                 330                 335    
 Tyr Asp Lys Asp Asn Asp Gly Arg Leu Asp Pro Gln Glu Leu Leu Pro
             340                 345                 350        
 Trp Val Val Pro Asn Asn Gln Gly Ile Ala Gln Glu Glu Ala Leu His
         355                 360                 365            
 Leu Ile Asp Glu Met Asp Leu Asn Gly Asp Lys Lys Leu Ser Glu Glu
     370                 375                 380                
 Glu Ile Leu Glu Asn Pro Asp Leu Phe Leu Thr Ser Glu Ala Thr Asp
 385                 390                 395                 400
 Tyr Gly Arg Gln Leu His Asp Asp Tyr Phe Tyr His Asp Glu Leu
                 405                 410                 415



      <210> 1529
      <211> 476
      <212> PRT
      <213> Homo sapiens


      <400> 1529
 Met Leu Gly Leu Ala Lys Arg Val Gly Ala Arg Leu Leu Leu Ala Ser
   1               5                  10                  15    
 Thr Ser Glu Val Tyr Gly Asp Pro Glu Val His Pro Gln Ser Glu Asp
              20                  25                  30        
 Tyr Trp Gly His Val Asn Pro Ile Gly Pro Arg Ala Cys Tyr Asp Glu
          35                  40                  45            
 Gly Lys Arg Val Ala Glu Thr Met Cys Tyr Ala Tyr Met Lys Gln Gly
      50                  55                  60                
 Gly Ala Gly Ala Asn Glu Leu Cys Arg Glu Gly Gly Gly Leu Gly Thr
  65                  70                  75                  80
 Gly Tyr Pro Ile His Val Leu Thr Glu Cys Val Leu Gly Leu Gly Ser
                  85                  90                  95    
 Glu Phe Ser His Pro His Glu Asn Ala Leu Trp Tyr Ser Gly Thr Cys
             100                 105                 110        
 Arg Leu Lys Gln Glu Gly Val Glu Val Arg Val Ala Arg Ile Phe Asn
         115                 120                 125            
 Thr Phe Gly Pro Arg Met His Met Asn Asp Gly Arg Val Val Ser Asn
     130                 135                 140                
 Phe Ile Leu Gln Ala Leu Gln Gly Glu Pro Leu Thr Pro Ala Cys Glu
 145                 150                 155                 160
 Asp Leu Leu Arg His Thr Phe Gly Leu Leu Ala Val Ala Arg Gly Pro
                 165                 170                 175    
 Arg Tyr His Pro Pro Leu Ala Thr Leu Asn Pro Gly Arg Leu Leu Glu
             180                 185                 190        
 Pro Ala Glu Val Pro Val Ile Cys Gly Arg Trp Ser Lys Cys Val Ala
         195                 200                 205            
 Lys Met Ser Val Pro Thr Leu Thr Ala Trp Tyr Pro Gln Ile Pro Ser
     210                 215                 220                
 Gly Val Arg Thr Gly Glu Pro Thr Ile Thr Val Ala Leu Thr Glu Cys
 225                 230                 235                 240
 Gly Gly Lys Val Gln Asn Lys Gln Gln Arg Cys Ile Cys Ala Leu Ser
                 245                 250                 255    
 Phe Glu Ser Arg Ala Pro Asp Ala Asp Arg Gly Asn Gly Gln Asp Ser
             260                 265                 270        
 Ser Thr Ala Pro Asn Pro Pro Val Glu Glu Pro Val Thr Arg Glu Leu
         275                 280                 285            
 Pro Lys Ser Asp Thr His Tyr Ser Glu Gly Gly Thr Gln Ala Asn Lys
     290                 295                 300                
 Thr Pro Glu Gly Thr Leu Val Pro Val Met Pro Arg Leu Gly Asp Leu
 305                 310                 315                 320
 Pro Lys His Leu Cys Cys Arg Leu Arg Leu Ser Ile Arg Ile Arg Val
                 325                 330                 335    
 Ser Asp Lys Gly Val Pro Val Arg Gln Ser His Thr Leu Lys Leu Leu
             340                 345                 350        
 Lys Ile Arg Thr Lys Pro Cys Asp Leu Val Asn Gly Leu Val Ala Leu
         355                 360                 365            
 Met Asn Ser Asn Val Ser Ser Pro Val Asn Leu Gly Asn Pro Glu Glu
     370                 375                 380                
 His Thr Ile Leu Glu Phe Ala Gln Leu Ile Lys Asn Leu Val Gly Ser
 385                 390                 395                 400
 Gly Ser Glu Ile Gln Phe Leu Ser Glu Ala Gln Asp Asp Pro Gln Lys
                 405                 410                 415    
 Arg Lys Pro Asp Ile Lys Lys Ala Lys Leu Met Leu Gly Trp Glu Pro
             420                 425                 430        
 Val Val Pro Leu Glu Glu Gly Leu Asn Lys Ala Ile His Tyr Phe Arg
         435                 440                 445            
 Lys Glu Leu Glu Tyr Gln Ala Asn Asn Gln Tyr Ile Pro Lys Pro Lys
     450                 455                 460                
 Pro Ala Arg Ile Lys Lys Gly Arg Thr Arg His Ser
 465                 470                 475    



      <210> 1530
      <211> 696
      <212> PRT
      <213> Homo sapiens

      <220>
      <221> misc_feature
      <222> (1)...(696)
      <223> Xaa = any amino acid or nothing 


      <400> 1530
 Met Pro Gly Met Pro Arg Cys Gln Gly Thr Tyr Leu Gly Lys Cys Ala
   1               5                  10                  15    
 Val Leu Leu Arg Phe Leu Ser Ser Ala Ser Tyr Lys Asn Thr Lys Tyr
              20                  25                  30        
 His Gln Arg Ile Tyr Lys His Leu Tyr Thr Asn Lys Leu Glu Asn Leu
          35                  40                  45            
 Glu Glu Ile Asp Lys Phe Leu Asn Thr Tyr Thr Leu Pro Arg Leu Asn
      50                  55                  60                
 Gln Glu Glu Val Glu Ser Leu Asn Arg Pro Ile Thr Gly Ala Glu Ile
  65                  70                  75                  80
 Val Ala Ile Ile Asn Ser Leu Pro Thr Lys Arg Ser Pro Gly Pro Asp
                  85                  90                  95    
 Gly Phe Thr Ala Lys Phe Tyr Gln Arg Tyr Lys Glu Glu Leu Val Pro
             100                 105                 110        
 Phe Leu Leu Lys Leu Phe Gln Ser Ile Glu Lys Glu Gly Ile Leu Pro
         115                 120                 125            
 Asn Ser Xaa Tyr Glu Ala Ser Ile Ile Leu Ile Pro Lys Pro Gly Arg
     130                 135                 140                
 Asp Thr Thr Lys Lys Glu Asn Phe Arg Pro Ile Ser Leu Ile Asn Ile
 145                 150                 155                 160
 Asp Ala Lys Ile Leu Asn Lys Ile Leu Ala Asn Arg Ile Gln Trp His
                 165                 170                 175    
 Ile Lys Lys Leu Ile His His Asp Gln Val Gly Phe Ile Pro Gly Met
             180                 185                 190        
 Gln Gly Trp Phe Asn Ile Arg Lys Ser Ile Asn Gly Ile Gln His Ile
         195                 200                 205            
 Asn Arg Thr Lys Asp Lys Asn His Met Met Ile Ser Ile Asp Ala Glu
     210                 215                 220                
 Lys Ala Phe Asp Lys Ile Gln Gln Pro Phe Met Leu Gln Thr Leu Asn
 225                 230                 235                 240
 Lys Leu Gly Ile Asp Gly Thr Tyr Leu Lys Ile Ile Arg Ala Ile Tyr
                 245                 250                 255    
 Asp Lys Pro Thr Ala Asn Ile Thr Leu Asn Gly Gln Lys Leu Glu Ala
             260                 265                 270        
 Phe Pro Leu Lys Thr Gly Arg Arg Gln Arg Cys Pro Leu Ser Pro Leu
         275                 280                 285            
 Leu Phe Asn Ile Val Leu Glu Val Leu Ala Arg Ala Ile Arg Gln Glu
     290                 295                 300                
 Lys Glu Ile Lys Gly Asn Gln Leu Gly Lys Glu Glu Val Lys Leu Ser
 305                 310                 315                 320
 Met Phe Ala Gly Asp Met Ile Val Tyr Leu Glu Asn Pro Ile Val Ser
                 325                 330                 335    
 Ala Gln Asn Leu Leu Lys Leu Ile Gly Asn Phe Ser Lys Phe Ser Gly
             340                 345                 350        
 Tyr Lys Ile Asn Val Gln Lys Ser Gln Ala Phe Leu Tyr Thr Asn Asn
         355                 360                 365            
 Arg Gln Thr Glu Asn Gln Ile Met Ser Glu Leu Pro Phe Thr Ile Ala
     370                 375                 380                
 Ser Lys Arg Ile Lys Tyr Leu Gly Ile Gln Leu Thr Arg Asp Val Lys
 385                 390                 395                 400
 Asp Leu Phe Lys Glu Asn Tyr Lys Pro Leu Leu Asn Glu Ile Lys Glu
                 405                 410                 415    
 Asp Thr Asn Lys Trp Lys Asn Ile Pro Cys Ser Trp Ile Gly Arg Ile
             420                 425                 430        
 Asn Ile Val Lys Met Ala Ile Leu Pro Lys Val Ile Tyr Arg Phe Asn
         435                 440                 445            
 Ala Ile Pro Ile Lys Leu Pro Thr Thr Phe Phe Thr Glu Leu Glu Lys
     450                 455                 460                
 Thr Thr Leu Lys Phe Leu Trp Asn Gln Lys Arg Ala His Ile Ala Lys
 465                 470                 475                 480
 Thr Ile Leu Ser Gln Lys Asn Lys Ala Gly Gly Ile Thr Leu Pro Asp
                 485                 490                 495    
 Phe Lys Leu Tyr Tyr Lys Ala Thr Val Thr Lys Thr Ala Trp Tyr Trp
             500                 505                 510        
 Tyr Gln Lys Arg Asp Ile Asp Gln Trp Asn Arg Ile Glu Leu Ser Glu
         515                 520                 525            
 Ile Ile Pro His Ile Tyr Asn His Leu Ile Phe Asp Lys Pro Asp Lys
     530                 535                 540                
 Asn Lys Lys Trp Gly Lys Asp Ser Val Phe Asn Lys Arg Cys Trp Glu
 545                 550                 555                 560
 Asn Trp Leu Ala Ile Cys Arg Lys Leu Lys Leu Asp Thr Phe Leu Thr
                 565                 570                 575    
 Pro Tyr Thr Lys Ile Asn Ser Arg Trp Ile Lys Asp Leu His Val Arg
             580                 585                 590        
 Pro Lys Ala Ile Lys Thr Leu Glu Glu Asn Leu Gly Asn Thr Ile Gln
         595                 600                 605            
 Asp Ile Gly Met Gly Lys Asp Phe Thr Ser Glu Thr Pro Lys Ala Met
     610                 615                 620                
 Ala Thr Lys Ala Lys Ile Asp Lys Trp Asp Leu Ile Thr Leu Lys Ser
 625                 630                 635                 640
 Phe Cys Thr Ala Lys Glu Thr Thr Ile Arg Val Asn Arg Gln Pro Thr
                 645                 650                 655    
 Glu Trp Glu Lys Ile Phe Ala Ile Tyr Ser Cys Val Lys Gly Leu Ile
             660                 665                 670        
 Ser Arg Ile Tyr Lys Glu Leu Lys Phe Ala Arg Ile Lys Gln Pro His
         675                 680                 685            
 Tyr Lys Val Gly Lys Gly Tyr Glu
     690                 695    



      <210> 1531
      <211> 342
      <212> PRT
      <213> Homo sapiens


      <400> 1531
 Met Ile Met Ala Trp Pro Leu Val Gly Thr Gln Leu Thr Ser Ala Met
   1               5                  10                  15    
 Asn Asp Gly Ser Pro Ser Val Cys Leu Cys Val Asn Asp Glu Leu Thr
              20                  25                  30        
 Asp Trp Ser Thr Val Leu Lys Glu Ser Ala Ala Ser Trp Ile Ser Gln
          35                  40                  45            
 Cys Leu Arg Gly Lys Leu Leu Gln Cys Thr Asp Val Gly Ser Gly Cys
      50                  55                  60                
 Pro Arg Ser Trp Leu Phe Leu Lys Lys Met Gln Pro Gly Leu Glu Asp
  65                  70                  75                  80
 Lys Leu Val Pro Gln Val Leu Leu Leu Leu Lys Lys Ser Lys Pro Gly
                  85                  90                  95    
 Trp Thr Thr Gly Leu Arg Pro Arg Cys Gly Phe Arg Trp Ser Phe Trp
             100                 105                 110        
 Gly Gly Pro Leu Lys Pro Pro Asn Gly Pro Glu Val His Gln Val Ile
         115                 120                 125            
 Asn Met Ala Thr Ser Gly Cys Arg Lys Glu Gln Met Gly Thr Glu Arg
     130                 135                 140                
 Glu His Pro Pro Leu Ser Gln Ser Phe Pro Ser Arg Val Leu Arg Ala
 145                 150                 155                 160
 Met Ala Asp Thr Ile Phe Gly Ser Gly Asn Asp Gln Trp Val Cys Pro
                 165                 170                 175    
 Asn Asp Arg Gln Leu Ala Leu Arg Ala Lys Ser Ile Glu Glu Ala Tyr
             180                 185                 190        
 Tyr Leu His Phe Ser Gly Arg Thr Pro Glu Arg Arg Gly Leu Pro Asp
         195                 200                 205            
 Arg Arg Lys Gln Gln Thr His Ser Ser His Gln Gly His Pro Ile Ser
     210                 215                 220                
 Glu Glu Leu Leu Gln Gly Ser Leu Glu Gln Val Trp Lys Arg Ser Gly
 225                 230                 235                 240
 Ala Trp Phe Tyr Lys Gly Leu Pro Lys Tyr Ile Leu Pro Leu Lys Thr
                 245                 250                 255    
 Pro Gly Arg Ala Asp Asp Pro His Phe Arg Pro Leu Pro Thr Glu Pro
             260                 265                 270        
 Ala Glu Arg Glu Pro Arg Ser Ser Glu Thr Ser Arg Ile Tyr Thr Trp
         275                 280                 285            
 Ala Arg Gly Arg Glu Glu Glu Thr Glu Ala Glu Arg Ser Pro Ser Thr
     290                 295                 300                
 Cys Thr Gly Pro His Cys Gln Arg Val Thr Glu Arg Gly Phe Glu Pro
 305                 310                 315                 320
 Lys Ala Arg Ala Leu Lys Leu Cys Val Val Thr Trp Tyr Pro Glu Asp
                 325                 330                 335    
 Pro Arg Leu Val Lys Asn
             340        



      <210> 1532
      <211> 742
      <212> PRT
      <213> Homo sapiens


      <400> 1532
 Met Pro Leu Arg Lys Thr Leu Ile Leu Thr Cys Phe Ser Arg Ile Leu
   1               5                  10                  15    
 Asp Leu Pro Ser His Asp Gly Leu Phe Leu Gly Leu Leu Asp Ile Met
              20                  25                  30        
 Thr Trp Val Ile Val Leu Gln Val Asn Asp His Arg Ser Leu Arg Lys
          35                  40                  45            
 Glu Thr Arg Glu Thr Phe Thr Ile Gly Asn Phe Leu Glu Arg Thr Trp
      50                  55                  60                
 Leu Phe Ser Phe Asn His Trp Val Leu Ser Leu Arg Thr Ala Ser Gly
  65                  70                  75                  80
 Pro Glu Thr Lys Ser Gln Glu Ser Ser Ile Phe Ile Gly Met Gly Phe
                  85                  90                  95    
 Leu Ala Tyr Gly Ser Val Phe Arg Ala Met Asn Ile Leu Pro Ser Phe
             100                 105                 110        
 Ile His Ser Ala Val Lys Gly Leu Cys Asp Val Ser Gly Met Gly Glu
         115                 120                 125            
 Thr Thr Ala Val Asn Ile Ile Glu His Thr Phe Cys Ala Tyr Met Asp
     130                 135                 140                
 Met Ala Leu Ser Val Leu Leu Trp Asn Met Gln His Glu Ser Ser Phe
 145                 150                 155                 160
 Ser Ser Val Lys Tyr Thr Ile Val Asp Ser Ser Val Ala Tyr Asp Cys
                 165                 170                 175    
 Ser Met Ala Lys Lys Arg Thr Ala Glu Asp Gln Ala Leu Gly Val Pro
             180                 185                 190        
 Val Asn Lys Arg Lys Ser Leu Leu Met Lys Pro Arg His Tyr Ser Pro
         195                 200                 205            
 Lys Ala Asp Cys Gln Glu Asp Arg Ser Asp Arg Thr Glu Asp Asp Gly
     210                 215                 220                
 Pro Leu Glu Thr His Gly His Ser Thr Ala Glu Glu Ile Met Ile Lys
 225                 230                 235                 240
 Pro Met Asp Glu Ser Leu Leu Ser Thr Ala Gln Glu Asn Ser Ser Arg
                 245                 250                 255    
 Lys Glu Asp Arg Tyr Ser Cys Tyr Gln Glu Leu Met Val Lys Ser Leu
             260                 265                 270        
 Met His Leu Gly Lys Phe Glu Lys Asn Val Ser Val Gln Thr Val Ser
         275                 280                 285            
 Glu Asn Leu Asn Asp Ser Gly Ile Gln Ser Leu Lys Ala Glu Ser Asp
     290                 295                 300                
 Glu Ala Asp Glu Cys Phe Leu Ile His Ser Asp Asp Gly Arg Asp Lys
 305                 310                 315                 320
 Ile Asp Asp Ser Gln Pro Pro Phe Cys Ser Ser Asp Asp Asn Glu Ser
                 325                 330                 335    
 Asn Ser Glu Ser Ala Glu Asn Gly Trp Asp Ser Gly Ser Asn Phe Ser
             340                 345                 350        
 Glu Glu Thr Lys Pro Pro Arg Val Pro Lys Tyr Val Leu Thr Asp His
         355                 360                 365            
 Lys Lys Asp Leu Leu Glu Val Pro Glu Ile Lys Thr Glu Gly Asp Lys
     370                 375                 380                
 Phe Ile Pro Cys Glu Asn Arg Cys Asp Ser Glu Thr Glu Arg Lys Asp
 385                 390                 395                 400
 Pro Gln Asn Ala Leu Ala Glu Pro Leu Asp Gly Asn Ala Gln Pro Ser
                 405                 410                 415    
 Phe Pro Asp Val Glu Glu Glu Asp Ser Glu Ser Leu Ala Val Met Thr
             420                 425                 430        
 Glu Glu Gly Ser Asp Leu Glu Lys Ala Lys Gly Asn Leu Ser Leu Leu
         435                 440                 445            
 Glu Gln Ala Ile Ala Leu Gln Ala Glu Arg Gly Cys Val Phe His Asn
     450                 455                 460                
 Thr Tyr Lys Glu Leu Asp Arg Phe Leu Leu Glu His Leu Ala Gly Glu
 465                 470                 475                 480
 Arg Arg Gln Thr Lys Val Ile Asp Met Gly Gly Arg Gln Ile Phe Asn
                 485                 490                 495    
 Asn Lys Arg Leu Phe Ile Ile Gln Gln Leu Gly Cys His Gly Met Ala
             500                 505                 510        
 Glu Ala Arg Leu Leu Ser Gln Tyr Ser Thr Pro Glu Met Ser Val Ala
         515                 520                 525            
 Ser Arg Asp Ser Gly Gln Thr Ser Cys Pro Val Ala Gln Glu His Thr
     530                 535                 540                
 Arg Leu Arg Thr Leu Ala Arg Arg Pro His Val Pro Thr Leu Ser Gly
 545                 550                 555                 560
 Cys Pro Ile Ala Ala Ala Glu Lys Leu Ala Met Ser Gln Asp Lys Asn
                 565                 570                 575    
 Gln Leu Asp Ser Pro Gln Thr Gly Gln Cys Pro Asp Gln Ala His Arg
             580                 585                 590        
 Thr Ser Leu Val Lys Gln Ile Glu Phe Asn Phe Pro Ser Gln Ala Ile
         595                 600                 605            
 Thr Ser Pro Arg Ala Thr Val Ser Lys Glu Gln Glu Lys Phe Gly Lys
     610                 615                 620                
 Val Pro Phe Asp Tyr Ala Ser Phe Asp Ala Gln Val Phe Gly Lys Arg
 625                 630                 635                 640
 Pro Leu Ile Gln Thr Val Gln Gly Arg Lys Thr Pro Pro Phe Pro Glu
                 645                 650                 655    
 Ser Lys His Phe Pro Asn Pro Val Lys Phe Pro Asn Arg Leu Pro Ser
             660                 665                 670        
 Ala Gly Ala His Thr Gln Ser Pro Gly Arg Ala Ser Ser Tyr Ser Tyr
         675                 680                 685            
 Gly Gln Cys Ser Glu Asp Thr His Ile Ala Ala Ala Ala Ala Ile Leu
     690                 695                 700                
 Asn Leu Ser Thr Arg Cys Arg Glu Ala Thr Asp Ile Leu Ser Asn Lys
 705                 710                 715                 720
 Pro Gln Ser Leu His Ala Lys Val Gly Gln Ser Lys Ser Pro Glu Gly
                 725                 730                 735    
 Gly Pro Ala Thr Glu Leu
             740        



      <210> 1533
      <211> 671
      <212> PRT
      <213> Homo sapiens


      <400> 1533
 Met Lys Phe Ala Phe Glu Glu Phe His Leu Trp Tyr Gln Phe Ala Leu
   1               5                  10                  15    
 Ser Leu Met Ala Ala Gly Lys Ala Lys Glu Leu Asn Val Met Glu Leu
              20                  25                  30        
 His Gly Met Ile Asp Phe Val Glu Val Phe Arg Ala Thr Leu Arg Asn
          35                  40                  45            
 Tyr Arg Gly Pro Phe Ser Ser Ala Arg Ala Val Lys Val Leu Lys Glu
      50                  55                  60                
 Cys Ile Arg Leu Lys Pro Asp Asp Ala Thr Ile Pro Leu Leu Ala Ala
  65                  70                  75                  80
 Lys Leu Cys Met Gly Ser Leu His Trp Leu Glu Glu Ala Glu Lys Phe
                  85                  90                  95    
 Ala Lys Thr Val Val Asp Val Gly Glu Lys Thr Ser Glu Phe Lys Ala
             100                 105                 110        
 Lys Gly Tyr Leu Ala Leu Gly Leu Thr Tyr Ser Leu Gln Ala Thr Asp
         115                 120                 125            
 Gly Ser His Ile Leu Leu Arg Lys Ala Ile Leu Lys Thr Val Glu Ser
     130                 135                 140                
 Thr Phe His Cys Met Ala His Thr Val Leu Gly Met Leu Ala Thr Cys
 145                 150                 155                 160
 Leu Pro Thr His Gln Val Gln Asp Thr Gly Gly Asn Pro Ser Thr Phe
                 165                 170                 175    
 Leu Ser Ala Asp Trp Glu Gly Asp Ser Lys Val Ser Ser Pro Asp Met
             180                 185                 190        
 Pro Phe Pro Trp Gln Ala Trp Ala Glu Ile Pro Glu Ala Leu Gly Tyr
         195                 200                 205            
 Val Arg Gln Ala Leu Gln Leu Gln Gly Asp Asp Ala Asn Ser Leu His
     210                 215                 220                
 Leu Leu Ala Leu Leu Leu Ser Ala Gln Lys His Tyr His Asp Ala Leu
 225                 230                 235                 240
 Asn Ile Ile Asp Met Ala Leu Ser Glu Tyr Pro Glu Asn Phe Ile Leu
                 245                 250                 255    
 Leu Phe Ser Lys Val Lys Leu Gln Ser Leu Cys Arg Gly Pro Asp Glu
             260                 265                 270        
 Ala Leu Leu Thr Cys Lys His Met Leu Gln Ile Trp Lys Ser Cys Tyr
         275                 280                 285            
 Asn Leu Thr Asn Pro Ser Trp Lys Ser Pro Ser Gln Ala Gln Glu Gln
     290                 295                 300                
 Arg Arg Gly Ala Val Leu Leu Gly Ala Pro Ala Leu Arg Leu Val Lys
 305                 310                 315                 320
 Glu Ser Ser Gln Lys Pro Leu Thr Gly Ser Val His Ala Thr Ser Val
                 325                 330                 335    
 Ala Ala Ser Arg Val Glu Gln Ala Leu Ser Glu Val Ala Ser Ser Leu
             340                 345                 350        
 Gln Ser Ser Ala Pro Lys Gln Gly Pro Leu His Pro Trp Met Thr Leu
         355                 360                 365            
 Ala Gln Ile Trp Leu His Ala Glu Gly Gly Gly Ile Glu Leu Trp Lys
     370                 375                 380                
 Val Thr Val Asp Pro Val Asn Pro Glu Gln Thr Val Leu Tyr Ala Tyr
 385                 390                 395                 400
 Gly Tyr Ala Ser Gly Gln Gly Lys Ser Ala Glu Glu Gly Ser Gly Leu
                 405                 410                 415    
 Gln Val Gly Glu Gly Val His Glu Pro Arg Gln Ser Gly Arg Pro Leu
             420                 425                 430        
 Arg Glu Ala Leu Gly Cys Arg Leu Asp His Val Ala Leu Leu Ala Leu
         435                 440                 445            
 Glu Arg Ala Glu Val Tyr Ile Gly Ile Gly Lys Pro Ala Glu Ala Thr
     450                 455                 460                
 Ala Cys Thr Gln Glu Ala Ala Asn Leu Phe Pro Met Ser His Asn Val
 465                 470                 475                 480
 Leu Tyr Met Arg Gly Gln Ile Ala Glu Leu Arg Gly Ser Met Asp Glu
                 485                 490                 495    
 Ala Arg Arg Trp Tyr Glu Glu Ala Leu Ala Ile Ser Pro Thr His Val
             500                 505                 510        
 Lys Ser Met Gln Arg Leu Val Thr Cys Lys Leu Gly Ala Glu Ala Glu
         515                 520                 525            
 Gln Glu Ser Arg Glu Ile Val Cys Trp Cys Gly Pro Leu Gly Thr Gln
     530                 535                 540                
 Ser Phe Ser Asp Arg Arg Trp Lys Asp Arg Glu His Gly Ala Asp Ala
 545                 550                 555                 560
 Ile Gly Asp Phe Glu Leu Lys Pro Val Phe Ile His Arg Phe Glu Asn
                 565                 570                 575    
 Pro Arg Ala Leu Lys Asn Tyr Ala Lys Leu Thr Leu Pro Val Leu Cys
             580                 585                 590        
 Lys Trp Asn Lys Lys Ala Trp Met Met Ala His Leu Phe Lys Ala Trp
         595                 600                 605            
 Phe Asn Asp Tyr Phe Met Pro Thr Val Asp Thr Tyr Ser Glu Lys Lys
     610                 615                 620                
 Ile Pro Leu Lys Ile Leu Leu Phe Ser Asp Asn Val Leu Gly Tyr Pro
 625                 630                 635                 640
 Arg Ala Leu Leu Glu Leu Tyr Lys Glu Met Thr Val Ile Phe Met Pro
                 645                 650                 655    
 Ala Asn Thr Ala Ser Thr Leu Gln Pro Met Asp Gln Gly Ala Ile
             660                 665                 670    



      <210> 1534
      <211> 1424
      <212> PRT
      <213> Homo sapiens


      <400> 1534
 Met Tyr Leu His Ser Val Phe Ser Phe Phe Cys Thr Tyr Val Ser Gly
   1               5                  10                  15    
 Ser Trp Val Tyr Lys Glu Gly His Asp Thr Glu Lys Gly Gly Glu Cys
              20                  25                  30        
 Lys Glu Arg Cys Met Gln Glu Cys Lys Gly Val Phe Thr Arg Asp Ser
          35                  40                  45            
 Val Gly Phe Pro Pro Gly Gly Glu Glu His Val Phe Glu Asn Ser Pro
      50                  55                  60                
 Val Leu Asp Glu Arg Ser Ala Leu Tyr Ser Gly Val His Lys Lys Pro
  65                  70                  75                  80
 Leu Phe Phe Asp Gly Ser Pro Glu Lys Pro Pro Glu Asp Asp Ser Asp
                  85                  90                  95    
 Ser Leu Thr Thr Ser Pro Ser Ser Ser Ser Leu Asp Thr Trp Gly Ala
             100                 105                 110        
 Gly Arg Lys Leu Val Lys Thr Phe Ser Lys Gly Glu Ser Arg Gly Leu
         115                 120                 125            
 Ile Lys Pro Pro Lys Lys Met Gly Thr Phe Phe Ser Tyr Pro Glu Glu
     130                 135                 140                
 Glu Lys Ala Gln Lys Val Ser Arg Ser Leu Thr Glu Gly Glu Met Lys
 145                 150                 155                 160
 Lys Gly Leu Gly Ser Leu Ser His Gly Val Ser Thr Asp Gly Val Cys
                 165                 170                 175    
 Phe Tyr Asp Asn His Arg Arg Arg His His Leu Leu Val Ser Leu Glu
             180                 185                 190        
 Glu Phe Gln Ser Val Arg Lys Gln Ile Arg Leu Lys Lys Thr Asp Thr
         195                 200                 205            
 Asn Tyr Ser Cys Ser Arg Ala Phe Leu Cys Gln Arg Pro Ser Arg Lys
     210                 215                 220                
 Gly Val Thr Ser Thr Thr Cys Asp Leu Gln Leu Leu Arg Gln Lys Gly
 225                 230                 235                 240
 Lys Gly Gly Gly Ser Cys Gly Phe Pro Gly Arg Arg Val Arg Gly Arg
                 245                 250                 255    
 Thr Ser Val Ser Glu Phe Asn Ile Thr Tyr Val Val Glu Arg Ser Leu
             260                 265                 270        
 Tyr Ser His Leu Asn Leu Thr Gln Leu Val Arg Pro Ala Ser Asp Arg
         275                 280                 285            
 Thr Leu Ser Lys Ala Glu Arg Gln Asp Leu Arg Arg Cys Leu Leu Glu
     290                 295                 300                
 Glu Asp Glu Glu Ala Lys Arg Lys Trp Ala Ala Thr Val Asp Arg Cys
 305                 310                 315                 320
 Thr Lys Arg Val Leu Leu Arg Ile His Gln Lys Ser Arg Phe Lys Ala
                 325                 330                 335    
 Lys Gln Asn Glu Ser Leu Phe Glu Lys Leu Ala Val Gly Val Arg Ala
             340                 345                 350        
 Val Gly Phe Gln Thr Trp Val Phe Arg Met Pro Glu Tyr Met Asp Pro
         355                 360                 365            
 Leu Thr His Ile Pro Ser Leu Ser Leu Leu Asn Val Ala Asp Val Arg
     370                 375                 380                
 Gly Ser Ser Val Leu Glu Thr Gly Asn Leu Thr Ala Leu Asp Ser Trp
 385                 390                 395                 400
 Arg Arg Thr Cys Ser Phe Gly Gly Phe Asp Leu Thr Asn Arg Ser Leu
                 405                 410                 415    
 His Val Gly Ser Asn Asn Ser Asp Pro Met Gly Lys Glu Gly Asp Phe
             420                 425                 430        
 Val Tyr Lys Glu Val Ile Lys Ser Pro Thr Ala Ser Arg Ile Ser Leu
         435                 440                 445            
 Gly Lys Lys Val Lys Ser Val Lys Glu Thr Met Arg Lys Arg Met Ser
     450                 455                 460                
 Lys Lys Tyr Ser Ser Ser Val Ser Glu Gln Pro Val Glu Val Pro Val
 465                 470                 475                 480
 Tyr Glu Leu Val Val Cys Leu Lys Tyr Val Ala Cys Asn Leu Asp Ala
                 485                 490                 495    
 Ser Cys Ala Gln Phe Thr Ile Gly Phe Val Leu Leu Arg Glu Ser Asn
             500                 505                 510        
 Thr Ala Ala Asp Leu Thr Gly Gly Gly Ala Gln Thr Val Met Arg Pro
         515                 520                 525            
 Asp Pro Glu His Leu Asp Lys Pro Lys Leu Lys Ala Gly Gly Ser Val
     530                 535                 540                
 Glu Ser Leu Arg Ser Ser Leu Ser Gly Gln Ser Ser Met Ser Gly Gln
 545                 550                 555                 560
 Thr Val Ser Thr Thr Asp Ser Ser Thr Ser Asn Arg Glu Ser Val Lys
                 565                 570                 575    
 Ser Glu Asp Gly Asp Asp Glu Glu Pro Pro Tyr Arg Gly Pro Phe Cys
             580                 585                 590        
 Gly Arg Ala Arg Val His Thr Asp Phe Thr Pro Ser Pro Tyr Asp Thr
         595                 600                 605            
 Asp Ser Leu Lys Leu Lys Ile Leu Asp Leu Tyr Val His Gly Met Tyr
     610                 615                 620                
 Leu Met Glu Arg Ser Leu Leu Pro Gly Pro Gln Lys Gly Asp Ile Ile
 625                 630                 635                 640
 Asp Ile Ile Ser Lys Pro Pro Met Gly Thr Trp Met Gly Leu Leu Asn
                 645                 650                 655    
 Asn Lys Val Gly Thr Phe Lys Phe Ile Tyr Val Asp Val Leu Ser Glu
             660                 665                 670        
 Asp Glu Glu Lys Pro Lys Arg Pro Thr Arg Arg Arg Arg Lys Gly Arg
         675                 680                 685            
 Pro Pro Gln Pro Lys Ser Val Glu Asp Leu Leu Asp Arg Ile Asn Leu
     690                 695                 700                
 Lys Glu His Met Pro Thr Phe Leu Phe Asn Gly Tyr Glu Asp Leu Asp
 705                 710                 715                 720
 Thr Phe Lys Leu Leu Glu Glu Glu Asp Leu Asp Glu Leu Asn Ile Arg
                 725                 730                 735    
 Asp Pro Glu His Arg Ala Val Leu Leu Thr Ala Val Glu Leu Leu Gln
             740                 745                 750        
 Glu Tyr Asp Ser Asn Ser Asp Gln Ser Gly Ser Gln Glu Lys Leu Leu
         755                 760                 765            
 Val Asp Ser Gln Gly Leu Ser Gly Cys Ser Pro Arg Asp Ser Gly Cys
     770                 775                 780                
 Tyr Glu Ser Ser Glu Asn Leu Glu Asn Gly Asn Val Ser Met Ser Arg
 785                 790                 795                 800
 Trp Glu Pro Ala Leu Thr Ser Lys Thr Arg Lys Ala Ser Leu Leu Ser
                 805                 810                 815    
 Ala Lys Ser Ser Thr Glu Pro Ser Leu Lys Ser Phe Ser Arg Asn Gln
             820                 825                 830        
 Leu Gly Asn Tyr Pro Thr Leu Pro Leu Met Lys Ser Gly Asp Ala Leu
         835                 840                 845            
 Lys Gln Gly Gln Glu Glu Gly Arg Leu Gly Gly Gly Leu Ala Pro Asp
     850                 855                 860                
 Thr Ser Lys Ser Cys Asp Pro Pro Gly Val Thr Gly Leu Asn Lys Asn
 865                 870                 875                 880
 Arg Arg Ser Leu Pro Val Ser Ile Cys Arg Ser Cys Glu Thr Leu Glu
                 885                 890                 895    
 Gly Pro Gln Thr Val Asp Thr Trp Pro Arg Ser His Ser Leu Asp Asp
             900                 905                 910        
 Leu Gln Val Glu Pro Gly Ala Glu Gln Asp Val Pro Thr Glu Val Thr
         915                 920                 925            
 Glu Pro Pro Pro Gln Ile Val Pro Glu Val Pro Gln Lys Thr Thr Ala
     930                 935                 940                
 Ser Ser Thr Lys Ala Gln Pro Leu Glu Gln Asp Ser Ala Val Asp Asn
 945                 950                 955                 960
 Ala Leu Leu Leu Thr Gln Ser Lys Arg Phe Ser Glu Pro Gln Lys Leu
                 965                 970                 975    
 Thr Thr Lys Lys Leu Glu Gly Ser Ile Ala Ala Ser Gly Arg Gly Leu
             980                 985                 990        
 Ser Pro Pro Gln Cys Leu Pro Arg Asn Tyr Asp Ala Gln Pro Pro Gly
         995                1000                1005            
 Ala Lys His Gly Leu Ala Arg Thr Pro Leu Glu Gly His Arg Lys Gly
    1010                1015                1020                
 His Glu Phe Glu Gly Thr His His Pro Leu Gly Thr Lys Glu Gly Val
1025                1030                1035                1040
 Asp Ala Glu Gln Arg Met Gln Pro Lys Ile Pro Ser Gln Pro Pro Pro
                1045                1050                1055    
 Val Pro Ala Lys Lys Ser Arg Glu Arg Leu Ala Asn Gly Leu His Pro
            1060                1065                1070        
 Val Pro Met Gly Pro Ser Gly Ala Leu Pro Ser Pro Asp Ala Pro Cys
        1075                1080                1085            
 Leu Pro Val Lys Arg Gly Ser Pro Ala Ser Pro Thr Ser Pro Ser Asp
    1090                1095                1100                
 Cys Pro Pro Ala Leu Ala Pro Arg Pro Leu Ser Gly Gln Ala Pro Gly
1105                1110                1115                1120
 Ser Pro Pro Ser Thr Arg Pro Pro Pro Trp Leu Ser Glu Leu Pro Glu
                1125                1130                1135    
 Asn Thr Ser Leu Gln Glu His Gly Val Lys Leu Gly Pro Ala Leu Thr
            1140                1145                1150        
 Arg Lys Val Ser Cys Ala Arg Gly Val Asp Leu Glu Thr Leu Thr Glu
        1155                1160                1165            
 Asn Lys Leu His Ala Glu Gly Ile Asp Leu Thr Glu Glu Pro Tyr Ser
    1170                1175                1180                
 Asp Lys His Gly Arg Cys Gly Ile Pro Glu Ala Leu Val Gln Arg Tyr
1185                1190                1195                1200
 Ala Glu Asp Leu Asp Gln Pro Glu Arg Asp Val Ala Ala Asn Met Asp
                1205                1210                1215    
 Gln Ile Arg Val Lys Gln Leu Arg Lys Gln His Arg Met Ala Ile Pro
            1220                1225                1230        
 Ser Gly Gly Leu Thr Glu Ile Cys Arg Lys Pro Val Ser Pro Gly Cys
        1235                1240                1245            
 Ile Ser Ser Val Ser Asp Trp Leu Ile Ser Ile Glu Leu Arg Val Cys
    1250                1255                1260                
 Val Ser Val Ser Val Ser Val Arg Glu Lys Gly Arg Arg Glu Arg Gly
1265                1270                1275                1280
 Arg Glu Asp Glu Cys Ser Phe Arg Ser Arg Ser Gly Pro Leu Ile Arg
                1285                1290                1295    
 Glu Pro Trp Glu Pro Leu Phe Gly Asn Ile Pro Ile Ser Asn Thr Ala
            1300                1305                1310        
 Pro Leu Pro His Asp Leu Arg Glu Glu Tyr Ser Glu Lys Gly Ile Ser
        1315                1320                1325            
 Cys His Leu Leu His Thr Val Thr Lys Thr Pro Glu Asp Pro Asn Gln
    1330                1335                1340                
 Thr Glu Phe Glu Phe Asn Leu Glu Gly Ser Gln Gly Thr Cys Val Thr
1345                1350                1355                1360
 Ala Thr Ala Val Lys Thr Asn Leu Val Gly Phe Tyr His His Pro His
                1365                1370                1375    
 Ser Ser Ser Met Asp Phe Pro Gln Asn Leu Gly Asn Glu Tyr Gly Trp
            1380                1385                1390        
 Asn His Lys Arg Asp Val Tyr Lys Trp Leu Trp Glu Leu Glu Gly Gly
        1395                1400                1405            
 Trp Ile Trp Pro Gly Asp Arg Glu Gly Gln Arg Arg Trp Phe Tyr Gly
    1410                1415                1420                





      <210> 1535
      <211> 227
      <212> PRT
      <213> Homo sapiens


      <400> 1535
 Met Val Trp Met Ala Val Ala Pro Pro Phe Ile Cys Gln Asn Leu Thr
   1               5                  10                  15    
 Leu Asn Ala Arg Ser Pro Leu Asn Arg Cys Pro Pro Pro Trp Arg Ala
              20                  25                  30        
 Ser Leu Arg Asp Tyr Arg Pro Ala Lys Gln Ser Pro Gln Ser Pro Pro
          35                  40                  45            
 Ser Gly Ala Pro Gly Pro Ser Gly Pro Ala Cys Pro Ala Leu Gly Ile
      50                  55                  60                
 Arg Ser Val Pro Val Leu Arg Ala Thr Arg Ser Met Asp Met Gly Thr
  65                  70                  75                  80
 Gln Gly Ser Gly Arg Lys Arg Leu Pro Asn Arg Glu Arg Leu Thr Ala
                  85                  90                  95    
 Glu Asp Asp Ala Leu Asn Gln Ile Ala Arg Glu Asp Phe Glu Arg His
             100                 105                 110        
 Pro Trp Leu Leu Pro Ser Arg Arg Gln Glu Leu Leu Ala Ile Pro Ser
         115                 120                 125            
 Cys Asp His Gln Thr Cys Phe Gln Thr Leu Ser Asn Gly Pro Trp Gly
     130                 135                 140                
 Thr Arg Tyr Pro Thr Glu Asp Leu Cys Val Arg Leu Leu Lys Ile Gln
 145                 150                 155                 160
 Val Trp Leu Gln Glu Lys Gly Gln Gly Arg Pro Ser Thr Leu Val Ser
                 165                 170                 175    
 Pro Val Glu Val Gly Leu Glu Thr Gln Ser Ser Phe Thr Pro Gln Asp
             180                 185                 190        
 His Pro Pro Asp Glu Lys Gly Asp Trp Met Leu Asp Asn Arg Lys Asp
         195                 200                 205            
 Pro Ser Gly Ile His Ile Ala Phe Cys His Gln Phe Thr Leu Asp Ser
     210                 215                 220                
 Ser Asn Pro
 225        



      <210> 1536
      <211> 326
      <212> PRT
      <213> Homo sapiens


      <400> 1536
 Met Thr Gly Ala Ala Ser Gln Phe Ser Gln Phe Asn Ile Met Leu Thr
   1               5                  10                  15    
 Leu Leu Ile Asn Leu Gln Ser Phe Leu Leu Asp Phe Gln Gln Asp Leu
              20                  25                  30        
 Glu Arg Lys Leu Lys Gly Asn Ser Gly Trp Pro Ser Leu Gly Cys Met
          35                  40                  45            
 Ile Ile Ala Glu Pro Ile Thr Met Val Lys Val Trp Arg Asn Gln Glu
      50                  55                  60                
 Gly Lys Leu Phe Ser Arg Ile Ser Met Ser Phe Ile Ser Leu Ile Asp
  65                  70                  75                  80
 Gln Thr Val Tyr Lys Gly Tyr Leu Glu Thr Gly Ile Leu Phe Phe Ser
                  85                  90                  95    
 Phe Ser Ser Arg Ser Thr Ser Glu Arg Thr Leu Trp Ser Asn Pro Gly
             100                 105                 110        
 Leu Ala Thr Ser Val Arg Ser Pro Asp Ala Gln Gly Arg Val Cys Ser
         115                 120                 125            
 Leu Gly Arg Pro Ser Ala Phe Ile Gly Val Ser Gln Lys Val Leu Glu
     130                 135                 140                
 Lys Ala Ile Arg Ser Met Ala Cys Ala Leu Met Asp Tyr Ala Thr Tyr
 145                 150                 155                 160
 Thr Ala Ser Gly Ile Arg Glu Gln Asp Asn Asn Thr Ile Thr Asn Asn
                 165                 170                 175    
 Asn Lys Met Thr Trp Met Glu Leu Glu Thr Ile Ile Leu Ser Glu Leu
             180                 185                 190        
 Thr Gln Glu Gln Arg Thr Lys His Arg Tyr Val Pro Ile Tyr Lys Trp
         195                 200                 205            
 Glu Leu Asn Asn Glu Asn Thr Trp Thr Gln Gly Gly Thr Pro Arg His
     210                 215                 220                
 Lys Glu Val Ser Val Ile Tyr Ala Thr Asp Tyr Gln Asp Glu Asp Cys
 225                 230                 235                 240
 Gln Ser Arg Leu Ile Lys Thr Ser Glu His Asp Thr Asp Leu Phe Tyr
                 245                 250                 255    
 Tyr Arg Cys Ile Ala Gln Val Phe Ser Phe Leu Phe Ser Trp Trp Asn
             260                 265                 270        
 Leu Glu Gly Val Met Asn Gln Ala Asp Ala Pro Arg Pro Leu Asn Trp
         275                 280                 285            
 Thr Ile Arg Lys Leu Cys His Ala Ala Phe Leu Pro Ser Val Arg Leu
     290                 295                 300                
 Leu Lys Phe Ala Asn Tyr Glu Met Ile Leu Lys Val Leu Ser Thr Phe
 305                 310                 315                 320
 Asn Ile Leu Glu Phe Thr
                 325    



      <210> 1537
      <211> 367
      <212> PRT
      <213> Homo sapiens


      <400> 1537
 Met Val Ile Ser His Met Ala Val Ser Gly Val Gly Ile Trp Ile Ala
   1               5                  10                  15    
 Phe Thr Ser Gly Ser Thr Leu Arg Leu Phe His Thr Glu Thr Leu Lys
              20                  25                  30        
 His Leu Gln Asp Ile Asn Ile Ala Thr Pro Val His Asn Met Leu Pro
          35                  40                  45            
 Gly Gly Glu Asp Gly Ala Gly Ala Glu Thr Thr Pro Val Ala Glu Pro
      50                  55                  60                
 Thr Lys Leu Val Leu Pro Met Lys Val Asn Pro Tyr Ser Val Ile Asp
  65                  70                  75                  80
 Ile Thr Pro Phe Gln Glu Asp Gln Pro Pro Thr Pro Val Pro Ser Ala
                  85                  90                  95    
 Glu Glu Glu Asn Val Gly Leu His Val Pro Cys Gly Tyr Leu Val Pro
             100                 105                 110        
 Val Pro Cys Gly Tyr Ala Val Pro Ser Asn Leu Pro Leu Leu Leu Pro
         115                 120                 125            
 Ala Tyr Ser Ser Pro Val Ile Ile Cys Ala Thr Ser Leu Asp Glu Glu
     130                 135                 140                
 Ala Ala Tyr Pro Glu Arg Arg Ala Leu Pro Ala His Leu Leu Gly Ser
 145                 150                 155                 160
 Thr Gly Thr Asn Gly Arg Arg Thr Leu Gly His Gly His Gln Arg Leu
                 165                 170                 175    
 Ser Val Thr Ser Leu Leu Val Cys His Gly Leu Leu Met Val Gly Thr
             180                 185                 190        
 Ser Leu Gly Val Leu Val Ala Leu Pro Val Pro Arg Leu Gln Gly Ile
         195                 200                 205            
 Pro Lys Val Thr Gly Lys Met Pro Glu Ile Pro Lys Gly Lys His Asn
     210                 215                 220                
 Val Ala Asn Pro Lys Pro Ala Glu Val Lys Pro Thr Ala Pro Cys Val
 225                 230                 235                 240
 Gly Glu Glu Leu Thr Asp Ser Gly Ser Arg Tyr Leu Ile Arg Ser Asp
                 245                 250                 255    
 Asp Met Ile Glu Thr Val Tyr Asn Asp Arg Gly Glu Ile Val Lys Thr
             260                 265                 270        
 Lys Glu Arg Arg Val Phe Met Leu Asn Asp Val Leu Met Cys Ala Thr
         275                 280                 285            
 Val Ser Ser Arg Arg Val Met Ser Ser Gln Arg Tyr Leu Leu Lys Trp
     290                 295                 300                
 Ser Val Pro Leu Gly His Val Asp Ala Ile Glu Tyr Gly Ser Ser Ala
 305                 310                 315                 320
 Gly Thr Gly Glu His Ser Arg His Leu Ala Val His Pro Pro Glu Ser
                 325                 330                 335    
 Leu Ala Val Val Ala Asn Ala Lys Pro Met Asn Pro Ala Ala Ser Ala
             340                 345                 350        
 Ala Thr Leu Cys Ala Pro Pro Cys Ser Lys Lys Asp Asp Leu Ile
         355                 360                 365        



      <210> 1538
      <211> 270
      <212> PRT
      <213> Homo sapiens


      <400> 1538
 Met Glu Pro Arg Thr Ser Leu Ile Gly Gln Tyr Leu Phe Leu Ile Phe
   1               5                  10                  15    
 Met Leu Gly Pro Gly Gln Leu Pro Leu Ile Asp Gly Lys Val Leu Arg
              20                  25                  30        
 Glu Thr Ser Ile Leu Glu Glu Tyr Ser Ile Asn Trp Thr Gln Lys Leu
          35                  40                  45            
 Gly Ala Gly Ile Ser Gly Pro Val Arg Val Cys Val Lys Lys Ser Thr
      50                  55                  60                
 Gln Glu Arg Phe Ala Leu Lys Ile Leu Leu Asp Arg Pro Lys Ala Arg
  65                  70                  75                  80
 Asn Glu Ile Ala Leu Ala Leu Arg His Cys His Leu Leu Asn Ile Ala
                  85                  90                  95    
 His Arg Asp Leu Lys Pro Glu Asn Leu Leu Phe Lys Asp Asn Ser Leu
             100                 105                 110        
 Asp Ala Pro Val Lys Leu Cys Asp Phe Gly Phe Ala Lys Ile Asp Gln
         115                 120                 125            
 Gly Asp Leu Met Thr Pro Gln Phe Thr Pro Tyr Tyr Val Ala Pro Gln
     130                 135                 140                
 Tyr Leu Pro Pro Glu Trp Cys Lys Ser Leu Gln Met Asp Leu Ser Cys
 145                 150                 155                 160
 Asp Leu Trp Ser Leu Gly Val Ile Ile Tyr Val Met Leu Cys Gly Tyr
                 165                 170                 175    
 Pro Pro Phe Tyr Ser Lys His His Ser Arg Thr Ile Pro Lys Asp Met
             180                 185                 190        
 Arg Arg Lys Ile Met Thr Gly Ser Phe Glu Phe Pro Glu Glu Glu Trp
         195                 200                 205            
 Ser Gln Ile Ser Glu Met Ala Lys Asp Val Val Arg Lys Leu Leu Lys
     210                 215                 220                
 Val Lys Pro Glu Glu Arg Leu Thr Ile Glu Gly Val Leu Asp His Pro
 225                 230                 235                 240
 Trp Leu Asn Ser Thr Glu Ala Leu Asp Asn Val Leu Pro Ser Ala Gln
                 245                 250                 255    
 Leu Met Met Asp Lys Val Leu Asn Asp Val Tyr Phe Val Gly
             260                 265                 270



      <210> 1539
      <211> 146
      <212> PRT
      <213> Homo sapiens


      <400> 1539
 Met Ala Gly Leu Pro Gln Val Ser Ala Gln Leu Leu Cys Ile Pro Ala
   1               5                  10                  15    
 Pro Leu Leu Glu Ala Ser Gln Glu Val Val Asn Asn Thr Trp Ile Glu
              20                  25                  30        
 Gly Ser Gly Asp Thr Leu His Gln Gln Leu Gly Ile Gln Glu Gln Gly
          35                  40                  45            
 Lys Lys Phe Leu Val Thr Ile Gly Ile Ile His Leu Gln Glu Ile Arg
      50                  55                  60                
 Gln Ala Gln Arg Glu Gly Val Phe Ala Leu Phe Ala Ser Pro Leu Asp
  65                  70                  75                  80
 Pro Ser Leu Ser Thr Gly Leu Pro Ser Ser Ser Phe Met Pro Trp Pro
                  85                  90                  95    
 Gly Phe Lys Ser Val Cys Gly Ser Arg Ala Pro Leu Arg Arg Glu Asp
             100                 105                 110        
 Arg Thr Arg Thr Gln Ser Lys Gly Gln Pro Cys Glu Asp Ser Glu Lys
         115                 120                 125            
 Ala Ala Val Asp Thr Pro Arg Arg Glu Ala Trp Glu Glu Thr Asn Leu
     130                 135                 140                
 Thr Pro
 145    



      <210> 1540
      <211> 912
      <212> PRT
      <213> Homo sapiens


      <400> 1540
 Met Leu Val Thr Ile Trp Ala Met Val Ala Thr Ala Val Leu Pro Leu
   1               5                  10                  15    
 Leu Thr Ala Val Leu Gly Val Thr Val Val Thr Arg Arg Asp Thr Glu
              20                  25                  30        
 Gly Pro Gly Arg Ala Ala Leu Val His Leu Thr Gly Ser Pro Arg Gln
          35                  40                  45            
 Lys Val Gly Thr Ser Gly Arg Glu Gly Leu Pro Gly Leu Gly Ala Ser
      50                  55                  60                
 Cys Ala Glu Ser Glu Leu Glu Arg Glu Thr Gln Glu Pro Arg Ser Arg
  65                  70                  75                  80
 Gly Arg Ala Ser Ala Ser Gln Asp Gly Ala Ala Ser Val Leu Gly Pro
                  85                  90                  95    
 Ser Cys Pro Leu Gly Ser Arg Val Leu Arg Pro Ala Pro Leu Ala Val
             100                 105                 110        
 Gly Ala Val His Ser Leu Pro Gln Ala Arg Gly Arg Cys Ser Pro Gln
         115                 120                 125            
 Glu Glu Gly Ala Glu Ala Ala Gly Glu Ala Ala Gly Gln Cys Asp Gly
     130                 135                 140                
 Gly Gly Ser Gly Glu Cys Gln Ala Val Pro Gly Thr Arg Ser Leu Leu
 145                 150                 155                 160
 Arg Arg Thr His Leu Cys Ser Leu Ser Lys Ser Asp Thr Arg Leu His
                 165                 170                 175    
 Glu Leu His Arg Gly Pro Arg Ser Ser Arg Ala Leu Arg Pro Ala Ser
             180                 185                 190        
 Met Asp Leu Leu Arg Pro His Trp Leu Glu Val Ser Arg Asp Ile Thr
         195                 200                 205            
 Gly Pro Gln Ala Ala Pro Ser Ala Phe Pro His Gln Glu Leu Pro Arg
     210                 215                 220                
 Ala Leu Pro Ala Ala Ala Ala Thr Ala Gly Cys Ala Gly Leu Glu Ala
 225                 230                 235                 240
 Thr Tyr Ser Asn Val Gly Leu Ala Ala Leu Pro Gly Val Ser Leu Ala
                 245                 250                 255    
 Ala Ser Pro Val Val Ala Glu Tyr Ala Arg Val Gln Lys Arg Lys Gly
             260                 265                 270        
 Thr His Arg Ser Pro Gln Glu Pro Gln Gln Gly Lys Thr Glu Val Thr
         275                 280                 285            
 Pro Ala Ala Gln Val Asp Val Leu Tyr Ser Arg Val Cys Lys Pro Lys
     290                 295                 300                
 Arg Arg Asp Pro Gly Pro Thr Thr Asp Pro Leu Asp Pro Lys Gly Gln
 305                 310                 315                 320
 Gly Ala Ile Leu Ala Leu Ala Gly Asp Leu Ala Tyr Gln Thr Leu Pro
                 325                 330                 335    
 Leu Arg Ala Leu Asp Val Asp Ser Gly Pro Leu Glu Asn Val Tyr Glu
             340                 345                 350        
 Ser Ile Arg Glu Leu Gly Asp Pro Ala Gly Arg Ser Ser Thr Glu Gly
         355                 360                 365            
 Pro Arg Leu Asn Lys Ala Pro Ala Gln Asp Glu Ser Gly Gln Pro Arg
     370                 375                 380                
 Ser Leu Leu Phe Leu Lys Ala Gly Arg Val Gly Ala Gly Gly Phe Ser
 385                 390                 395                 400
 Gly Arg Leu Gly Ala Val Pro Ser Gly Leu Gly Gly Leu Ala Ala Pro
                 405                 410                 415    
 Gly Ala Pro Gly Pro Ser Arg Gly Gly Ala Pro Ala Gly Gln Thr Leu
             420                 425                 430        
 Ala Ser Ala Pro Gly Arg Pro Ala Met Glu Arg Pro Pro Pro Arg Ala
         435                 440                 445            
 Ala Gly Arg Asp Pro Ser Ala Leu Arg Ala Glu Ala Pro Trp Leu Arg
     450                 455                 460                
 Ala Glu Gly Pro Gly Pro Arg Ala Ala Pro Val Thr Val Pro Thr Pro
 465                 470                 475                 480
 Pro Gln Gly Ser Ser Val Gly Gly Gly Phe Ala Gly Leu Glu Phe Ala
                 485                 490                 495    
 Arg Pro Gln Glu Ser Glu Pro Arg Ala Ser Asp Leu Gly Ala Pro Arg
             500                 505                 510        
 Thr Trp Thr Gly Ala Ala Ala Gly Pro Arg Thr Pro Ser Ala His Ile
         515                 520                 525            
 Pro Val Pro Ala Gln Arg Ala Thr Pro Gly Lys Ala Arg Leu Asp Glu
     530                 535                 540                
 Val Met Ala Ala Ala Ala Leu Thr Ser Leu Ser Thr Ser Pro Leu Leu
 545                 550                 555                 560
 Leu Gly Ala Pro Val Ala Ala Phe Ser Pro Val Pro Pro Thr Glu Ala
                 565                 570                 575    
 Lys Ala Ala Gly Pro Arg Pro Ser Gly Leu Pro Asp Leu Leu Thr Ser
             580                 585                 590        
 Thr Arg Leu Ala Thr His Val Cys Gln Pro Phe Pro Val Pro Gly Gly
         595                 600                 605            
 Phe Leu Pro Lys Pro Trp Gly Gln Leu Leu Gln Asp Ala Leu Pro Thr
     610                 615                 620                
 Ser Leu Thr Gly Leu Gly Glu Gln Gly Gln Leu Arg Ile Arg Asp Ser
 625                 630                 635                 640
 Leu Asp Pro Pro Glu Val Leu Arg Arg Gly Ala Arg Val Pro Thr Glu
                 645                 650                 655    
 Pro Gly Leu Glu Pro Trp Lys Glu Ala Leu Val Arg Pro Pro Gly Ser
             660                 665                 670        
 Tyr Ser Ser Ser Ser Asn Ser Gly Asp Trp Gly Trp Asp Leu Ala Ser
         675                 680                 685            
 Asp Gln Ser Ser Pro Ser Thr Pro Ser Pro Pro Leu Pro Pro Glu Ala
     690                 695                 700                
 Ala His Phe Leu Phe Gly Glu Pro Thr Leu Arg Lys Arg Lys Ser Pro
 705                 710                 715                 720
 Ala Gln Val Met Phe Gln Cys Leu Trp Lys Ser Cys Gly Lys Val Leu
                 725                 730                 735    
 Ser Thr Ala Ser Ala Met Gln Arg His Ile Arg Leu Val His Leu Gly
             740                 745                 750        
 Arg Gln Ala Glu Pro Glu Gln Ser Asp Gly Glu Glu Asp Phe Tyr Tyr
         755                 760                 765            
 Thr Glu Leu Asp Val Gly Val Asp Thr Leu Thr Asp Gly Leu Ser Ser
     770                 775                 780                
 Leu Thr Pro Val Ser Pro Thr Ala Ser Met Pro Pro Ala Phe Pro Arg
 785                 790                 795                 800
 Leu Glu Leu Pro Glu Leu Leu Glu Pro Pro Ala Leu Pro Ser Pro Leu
                 805                 810                 815    
 Arg Pro Pro Ala Pro Pro Leu Pro Pro Pro Pro Val Leu Ser Thr Val
             820                 825                 830        
 Ala Asn Pro Gln Ser Cys His Ser Asp Arg Val Tyr Gln Gly Cys Leu
         835                 840                 845            
 Thr Pro Ala Arg Leu Glu Pro Gln Pro Thr Glu Val Gly Ala Cys Pro
     850                 855                 860                
 Pro Ala Leu Ser Ser Arg Ile Gly Val Thr Leu Arg Lys Pro Arg Gly
 865                 870                 875                 880
 Asp Ala Lys Lys Cys Arg Lys Val Tyr Gly Met Glu Arg Arg Asp Leu
                 885                 890                 895    
 Trp Cys Thr Ala Cys Arg Trp Lys Lys Ala Cys Gln Arg Phe Leu Asp
             900                 905                 910        





      <210> 1541
      <211> 842
      <212> PRT
      <213> Homo sapiens


      <400> 1541
 Met Leu Thr Val Met Cys Arg Ala Leu Leu Val Phe Leu Gly Glu Met
   1               5                  10                  15    
 Val Thr Leu Val Phe Gln Asp Asn Gln Gly Pro Leu Val Leu Leu Ala
              20                  25                  30        
 Pro Leu Glu Ser Val Asn His Ala Leu Leu Val Leu Arg Ile Ile Ser
          35                  40                  45            
 Ala Tyr Glu Thr Ala Leu Ala Asn Thr Ser Glu His Thr Leu Leu Leu
      50                  55                  60                
 Leu Lys His Gly Ser Gln Ile Asn Leu Gln Asn Tyr Ser Pro Gln Tyr
  65                  70                  75                  80
 Asp Ser Tyr Asp Val Lys Ser Gly Val Ala Val Gly Gly Leu Ala Gly
                  85                  90                  95    
 Tyr Pro Gly Pro Ala Val His Leu Val Leu Leu Glu Lys Met Glu Asn
             100                 105                 110        
 Gln Val Asp Pro Asp Asp Leu Glu Ser Glu Asp Cys Leu Asp Leu Gln
         115                 120                 125            
 Val Leu Gly Val Met Thr Val Leu Glu Ala Val Met Val Asn Gln Val
     130                 135                 140                
 Lys Leu Asp Leu Gln Gly Leu Leu Val Gln Met Val Pro Leu Asp Lys
 145                 150                 155                 160
 Glu Glu Asn Leu Asp Leu Arg Asp Thr Leu Val Leu Lys Val Leu Leu
                 165                 170                 175    
 Val Ser Leu Val Arg Met Val Pro Lys Glu Ser Pro Asp His Val Val
             180                 185                 190        
 Asn Ala Val Arg Leu Val Phe Gln Val Phe Gln Glu Leu Lys Ala Lys
         195                 200                 205            
 Met Ala Arg Met Asp His Leu Glu Asn Leu Val Gln Met Gly Phe Gln
     210                 215                 220                
 Glu Leu Gln Glu Lys Gly Val Leu Leu Val Arg Met Glu Asn Glu Val
 225                 230                 235                 240
 Ala Leu Glu Asp Leu Ala Leu Arg Gly Leu Val Val Thr Lys Glu Thr
                 245                 250                 255    
 Gln Asp Pro Leu Val His Lys Asp Tyr Lys Val Met Leu Val Pro Leu
             260                 265                 270        
 Val Asn Val Asp Leu Leu Asp Trp Gln Gly Pro Gln Asp Leu Glu Val
         275                 280                 285            
 Glu Leu Val Pro Leu Val Pro Lys Glu Glu Arg Val Asn Gln Ala Val
     290                 295                 300                
 Gln Val Leu Met Val Ser Gln Gly Lys Met Ala Gln Gly Val Lys Val
 305                 310                 315                 320
 Val Pro Arg Thr Ser Arg Val Arg Glu Val Lys Leu Ala Leu Gln Asp
                 325                 330                 335    
 Leu Leu Val Ser Leu Val Leu Leu Asp Arg Met Val Asn Leu Val Val
             340                 345                 350        
 Lys Glu Lys Glu Gly Leu Arg Val Arg Lys Val Lys Glu Ala Leu Leu
         355                 360                 365            
 Glu Leu Gln Asp Pro Leu Glu Val Leu Asp Leu Leu Val Leu Leu Val
     370                 375                 380                
 Pro Lys Val Ser Lys Val Asn Val Ala Val Leu Val Asp Leu Val Lys
 385                 390                 395                 400
 Val Gly Asn Gln Glu Leu Thr Val Ser Val Glu Asn Val Val Pro Leu
                 405                 410                 415    
 Asp Pro Arg Val Phe Leu Val Trp Leu Val Gln Leu Val Asn Leu Glu
             420                 425                 430        
 Glu Met Val Ile Val Val Lys Met Ala Leu Leu Val Pro Leu Ala Leu
         435                 440                 445            
 Leu Val Ile Gln Ala His Leu Val Leu Ser Val Gln Leu Glu Arg Val
     450                 455                 460                
 Val Thr Glu Glu Lys Val Val Leu Lys Ala His Val Val Thr Lys Val
 465                 470                 475                 480
 Lys Gln Val Asn Val Glu Leu Leu Ala Ser Lys Asp Ile Glu Asp Ser
                 485                 490                 495    
 Leu Val Ile Gln Val Pro Gln Val Leu Gln Ala Leu Leu Val Ser Arg
             500                 505                 510        
 Val Gln Ser Ala Val Gln Asp Leu Gln Ala Pro Glu Asp Leu Leu Asp
         515                 520                 525            
 Pro Val Asp Leu Leu Ala Lys Met Glu Pro Val Asp Ile Gln Val Pro
     530                 535                 540                
 Leu Asp His Gln Gly Leu Glu Gly Ser Pro Gly His Pro Gly Gln Pro
 545                 550                 555                 560
 Gly Pro Pro Gly Pro Pro Gly Ala Pro Gly Pro Cys Cys Gly Gly Val
                 565                 570                 575    
 Gly Ala Ala Ala Ile Ala Gly Ile Gly Gly Glu Lys Ala Gly Gly Phe
             580                 585                 590        
 Ala Pro Tyr Tyr Gly Asp Glu Pro Met Asp Phe Lys Ile Asn Thr Asp
         595                 600                 605            
 Glu Ile Met Thr Ser Leu Lys Ser Val Asn Gly Gln Ile Glu Ser Leu
     610                 615                 620                
 Ile Ser Pro Asp Gly Ser Arg Lys Asn Pro Ala Arg Asn Cys Arg Asp
 625                 630                 635                 640
 Leu Lys Phe Cys His Pro Glu Leu Lys Ser Gly Glu Tyr Trp Val Asp
                 645                 650                 655    
 Pro Asn Gln Gly Cys Lys Leu Asp Ala Ile Lys Val Phe Cys Asn Met
             660                 665                 670        
 Glu Thr Gly Glu Thr Cys Ile Ser Ala Asn Pro Leu Asn Val Pro Arg
         675                 680                 685            
 Lys His Trp Trp Thr Asp Ser Ser Ala Glu Lys Lys His Val Trp Phe
     690                 695                 700                
 Gly Glu Ser Met Asp Gly Gly Phe Gln Phe Ser Tyr Gly Asn Pro Glu
 705                 710                 715                 720
 Leu Pro Glu Asp Val Leu Asp Val His Leu Ala Phe Leu Arg Leu Leu
                 725                 730                 735    
 Ser Ser Arg Ala Ser Gln Asn Ile Thr Tyr His Cys Lys Asn Ser Ile
             740                 745                 750        
 Ala Tyr Met Asp Gln Ala Ser Gly Asn Val Lys Lys Ala Leu Lys Leu
         755                 760                 765            
 Met Gly Ser Asn Glu Gly Glu Phe Lys Ala Glu Gly Asn Ser Lys Phe
     770                 775                 780                
 Thr Tyr Thr Val Leu Glu Asp Gly Cys Thr Lys His Thr Gly Glu Trp
 785                 790                 795                 800
 Ser Lys Thr Val Phe Glu Tyr Arg Thr Arg Lys Ala Val Arg Leu Pro
                 805                 810                 815    
 Ile Val Asp Ile Ala Pro Tyr Asp Ile Gly Gly Pro Asp Gln Glu Phe
             820                 825                 830        
 Gly Val Asp Val Gly Pro Val Cys Phe Leu
         835                 840        



      <210> 1542
      <211> 1334
      <212> PRT
      <213> Homo sapiens


      <400> 1542
 Met Val Pro Ser Ser Pro Arg Ala Leu Phe Leu Leu Leu Leu Ile Leu
   1               5                  10                  15    
 Ala Cys Pro Glu Pro Arg Ala Ser Gln Arg Trp Ala Ala Glu Ser Leu
              20                  25                  30        
 His Thr Glu Cys Leu Val Arg Leu Arg Leu Pro Ala Gly His Leu Pro
          35                  40                  45            
 Val Thr Ser Phe Pro Glu Leu Pro Cys Glu Val Gly Thr Val Thr Pro
      50                  55                  60                
 Ile Leu Gln Met Met Lys Lys Tyr Ser Ser Pro Thr Arg Asp Ile Asn
  65                  70                  75                  80
 Ile Ala Leu Glu Gln Leu Leu Ala Glu Asp Ser Ile Asp Ala Ser Asp
                  85                  90                  95    
 Phe Ser Gln Ile Asp Asp Phe Asn Asp Ser Asp Asn Ser Asp Gln Pro
             100                 105                 110        
 Pro Leu Leu Pro Gly Thr Phe Lys Asn Glu Ile Tyr Ile Leu Ser Arg
         115                 120                 125            
 Ala Ala Leu Ile Ala Glu Glu Asn Gly Ser Pro Leu Ala Pro Leu Gly
     130                 135                 140                
 Ser Phe Leu Ala Leu Gly Ala Leu Gly Thr His Gln Ala Gly Arg Glu
 145                 150                 155                 160
 Lys Pro Asp Lys Leu Glu Lys Tyr Gln Arg Ala Asn Asp Cys Leu Ser
                 165                 170                 175    
 Gly Val Leu His Trp Arg Val Ala Thr Ser Tyr Ser Arg Leu Ser Lys
             180                 185                 190        
 Gln Val Gly Asn Ser Leu Arg Arg Gly Leu Leu Ser Arg Ser Gly Lys
         195                 200                 205            
 Thr Thr Leu Glu Asp Ser Thr Leu Glu Asp Leu Gly Ala Asp Ser Pro
     210                 215                 220                
 Gly Arg Gly Pro Ser Arg Cys Lys Gly Pro Lys Val Gly Val Ala Trp
 225                 230                 235                 240
 Gly Gly Ser Trp Arg Gly Leu Gln Leu Leu Asp Ala Met Cys Val Asp
                 245                 250                 255    
 Pro Lys Leu Leu Ala Trp Leu Gly His Trp Gly Pro Gln Arg Leu Ala
             260                 265                 270        
 Glu Asp Asn Thr Glu Ala Val Lys Gly Thr Thr Gln Ser Thr Gly Ala
         275                 280                 285            
 Asp Gly Leu Trp Thr Lys Asn His Pro Cys His Leu Tyr Ser Ser Leu
     290                 295                 300                
 Glu Lys Pro Gly Trp Gly Asp Ile Cys Cys Ser Phe Ser Asn Trp Phe
 305                 310                 315                 320
 Ser Ala Asn Ile Ala Ile Gly Val Lys Leu Asp Glu Val Leu Thr Pro
                 325                 330                 335    
 Leu Lys Ser Phe Ile Thr Glu Thr Asn Cys Leu Ser Lys Gln Gln Leu
             340                 345                 350        
 Leu Ser Ala Ile Arg Gln Leu Gln Gln Leu Leu Lys Gly Gln Glu Thr
         355                 360                 365            
 Arg Phe Ala Glu Gly Ile Arg His Met Lys Ser Arg Leu Ala Ala Leu
     370                 375                 380                
 Gln Asn Ser Val Gly Arg Ser Ser Phe Lys Phe Ile Ala Glu Leu Ser
 385                 390                 395                 400
 Gly Lys His Cys Val Pro Pro His Pro Leu Cys Val His Thr His Ala
                 405                 410                 415    
 His Ala His Ala His Ala His Ala His Ala Asp Ala Arg Thr Arg Thr
             420                 425                 430        
 His Ala Arg Thr His Thr Ser Thr Arg Thr Arg Thr His Thr His Thr
         435                 440                 445            
 Arg Ala Arg Thr His Ala Arg Thr Arg Arg Arg Thr Arg Thr His Thr
     450                 455                 460                
 His Thr Arg Thr His Thr His Ala His Thr Ser Thr His Thr Arg Thr
 465                 470                 475                 480
 His Thr Arg Thr His Thr His Thr His Ser Ala Arg Ala Ser Ala Ile
                 485                 490                 495    
 His Trp Phe Gln Ser Met Thr Lys Val Ile Thr Thr Gly Gly Gln Leu
             500                 505                 510        
 Gly Ala Leu Leu Lys Glu Gly Asp Ala Ala Met Gly Arg Tyr Ser Pro
         515                 520                 525            
 Ile Thr Lys Gly His Arg Ala Ser Ser Glu Gly Pro Ala Pro Pro Ser
     530                 535                 540                
 Ala Pro Ala Gln Ala Ala Thr Ala Ala Pro Gln Arg Thr Leu Gly Cys
 545                 550                 555                 560
 Val Arg Pro Arg His Leu Ser Gly Cys Ala Phe Thr Phe Asn Ser Phe
                 565                 570                 575    
 Cys Phe Leu Pro Gly Ser Glu His Pro Arg Arg Arg Gln Lys Val Trp
             580                 585                 590        
 Lys Gln Val Leu Ser Gly Ser Arg Ser Pro Phe Tyr Leu Gln Pro Trp
         595                 600                 605            
 Val Pro Ala Gly Arg Ala Gln Gln Arg Ala Ser Cys Ile Ala Leu Phe
     610                 615                 620                
 Pro Ser Thr Leu Thr Ser Thr Pro Lys Ser Cys Met Met Gln Pro Thr
 625                 630                 635                 640
 Phe Gly Met Pro Thr Gln Thr Ala Cys Ala Ile Lys Asn Leu Gly Arg
                 645                 650                 655    
 Thr Asn Ser Gly Asn Lys Pro Ile Phe Thr Glu His Gln Pro Phe Thr
             660                 665                 670        
 Lys Leu Val Pro Asp Ala Arg Asp Ser Met Ser Asn Pro Thr Asp Thr
         675                 680                 685            
 Thr Leu Ala Ser Gly Val His Arg Leu Arg Gly Glu Ala Lys Gln Ser
     690                 695                 700                
 Arg Gln Pro His Thr Lys Gly Ser Glu Leu Thr Phe Val Ile Thr Asp
 705                 710                 715                 720
 Lys Glu Ser Leu Asn Ala Ala Cys Leu Glu Met Asn Thr Leu Gly Gly
                 725                 730                 735    
 Ser Arg Glu Gly Asp Arg Val Tyr Gly Pro Gly Thr Ala Val Arg Phe
             740                 745                 750        
 Ser Ala Ala Pro Met Ile Pro Asn Thr His Pro His Gly Ser Gly Thr
         755                 760                 765            
 Asp Gln Ala Gln Cys Leu Leu Leu Ala Gly Ser Lys Gly Glu Thr Thr
     770                 775                 780                
 Ala Leu Ala Leu Leu Gly Pro Ser Tyr Lys Ile Leu Val Phe Thr Phe
 785                 790                 795                 800
 Ser Gly Ser Leu Pro Thr Thr Ser Arg Pro Ser Asp Leu Pro Thr Ser
                 805                 810                 815    
 Arg Leu Arg Trp Cys Trp Leu Met Glu Gln Lys Gly Cys Gly Leu Gln
             820                 825                 830        
 Gly Leu Thr Gln Arg Gln Cys Gly Gln Met Pro Thr Gly Ser His Phe
         835                 840                 845            
 Cys Leu Ala Thr Ala Val Tyr Thr Ala Pro Leu Gln Ile Arg Lys Trp
     850                 855                 860                
 Cys Leu Trp Val Gly Tyr Gly Gln Leu Ile Gly Gln Leu Leu His Ala
 865                 870                 875                 880
 Glu Pro Gln Gly Leu Leu Asn Gly Asp Ala Ile Gly Leu His Ile Ser
                 885                 890                 895    
 Pro Ile Gly Pro Leu Ala Ala Leu Ala Gly Gly Glu Gly Gly Lys Ser
             900                 905                 910        
 Ile Ser Glu Cys Ser Ser Gln Pro Cys Gln Asn Gly Gly Thr Cys Val
         915                 920                 925            
 Glu Gly Val Asn Gln Tyr Arg Cys Ile Cys Pro Pro Gly Arg Thr Gly
     930                 935                 940                
 Asn Arg Cys Gln His Gln Ala Gln Thr Ala Ala Pro Glu Gly Ser Val
 945                 950                 955                 960
 Ala Gly Asp Ser Ala Phe Ser Arg Ala Pro Arg Cys Ala Gln Val Glu
                 965                 970                 975    
 Arg Ala Gln His Cys Ser Cys Glu Ala Gly Phe His Leu Ser Gly Ala
             980                 985                 990        
 Ala Gly Asp Ser Val Cys Gln Asp Val Asn Glu Cys Glu Leu Tyr Gly
         995                1000                1005            
 Gln Glu Gly Arg Pro Arg Leu Cys Met His Ala Cys Val Asn Thr Pro
    1010                1015                1020                
 Gly Ser Tyr Arg Cys Thr Cys Pro Gly Gly Tyr Arg Thr Leu Ala Asp
1025                1030                1035                1040
 Gly Lys Ser Cys Glu Asp Val Asp Glu Cys Val Gly Leu Gln Pro Val
                1045                1050                1055    
 Cys Pro Gln Gly Thr Thr Cys Ile Asn Thr Gly Gly Ser Phe Gln Cys
            1060                1065                1070        
 Val Ser Pro Glu Cys Pro Glu Gly Ser Gly Asn Val Ser Tyr Val Lys
        1075                1080                1085            
 Thr Ser Pro Phe Gln Cys Glu Arg Asn Pro Cys Pro Met Asp Ser Arg
    1090                1095                1100                
 Pro Cys Arg His Leu Pro Lys Thr Ile Ser Phe His Tyr Leu Ser Leu
1105                1110                1115                1120
 Pro Ser Asn Leu Lys Thr Pro Ile Thr Leu Phe Arg Met Ala Thr Ala
                1125                1130                1135    
 Ser Ala Pro Gly Arg Ala Gly Pro Asn Ser Leu Arg Phe Gly Ile Val
            1140                1145                1150        
 Gly Gly Asn Ser Arg Gly His Phe Val Met Gln Arg Ser Asp Arg Gln
        1155                1160                1165            
 Thr Gly Asp Leu Ile Leu Val Gln Asn Leu Glu Gly Pro Gln Thr Leu
    1170                1175                1180                
 Glu Val Asp Val Asp Met Ser Glu Tyr Leu Asp Arg Ser Phe Gln Ala
1185                1190                1195                1200
 Asn His Val Ser Lys Glu Gly Val Ala Asp Ser Leu Pro Val Trp Val
                1205                1210                1215    
 Gly Tyr Thr Gly Ile Asn Glu Ser Glu Asn Thr Glu Val Met Phe Gly
            1220                1225                1230        
 Thr Val Pro His Tyr Lys Phe Val Leu Thr Thr Trp Glu Ile Glu Asn
        1235                1240                1245            
 Thr Ala Leu Asp Gly Ala Gly Thr Leu Asn Ala Leu Pro Gln Leu Pro
    1250                1255                1260                
 Glu Cys Gln Gly Gly Gln Phe Glu Thr Arg Ser Val Arg Val Ala Glu
1265                1270                1275                1280
 Ile Lys Gly Gly Trp Lys Ala Arg Cys Thr Leu Ala Trp Phe Thr Lys
                1285                1290                1295    
 Ala Ala Ser Asp Asn Arg Gly Asn Glu Leu Asn Thr Met Asn Val Val
            1300                1305                1310        
 Phe Gly Glu Glu Asp Gly Glu Gly Glu Lys His Gly Leu Trp Glu Glu
        1315                1320                1325            
 Glu Cys Arg Phe Ala Ser
    1330                



      <210> 1543
      <211> 176
      <212> PRT
      <213> Homo sapiens


      <400> 1543
 Met Glu Met Arg Val Pro Ala Gln Leu Leu Gly Leu Leu Leu Leu Trp
   1               5                  10                  15    
 Leu Arg Gly Ala Arg Cys Asp Ile Gln Val Thr Gln Ser Pro Ser Ser
              20                  25                  30        
 Leu Ser Ala Ser Val Gly Asp Arg Val Thr Ile Thr Cys Arg Ala Ser
          35                  40                  45            
 Gln Gly Ile Ser Asn Gly Leu Ser Trp Tyr Gln Gln Lys Pro Gly Gln
      50                  55                  60                
 Ala Pro Thr Leu Leu Ile Tyr Ala Ala Ser Ser Leu Gln Ser Gly Val
  65                  70                  75                  80
 Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr
                  85                  90                  95    
 Ile Ser Ser Leu Gln Pro Glu Asp Val Ala Thr Tyr Tyr Cys Leu Gln
             100                 105                 110        
 Asp Tyr Thr Thr Pro Phe Thr Val Leu Gln Ala Ile Thr Lys Thr Pro
         115                 120                 125            
 Gln Arg Ser Arg Cys Lys Glu Lys Leu Lys Gly Ser Gly Arg Pro Ser
     130                 135                 140                
 Val Glu Gly Cys Glu Ala Gln Val Ile Glu Val His Glu Glu Thr Asp
 145                 150                 155                 160
 Ser His Asp Pro Tyr Glu Ala Leu Val Glu Gly Ser Gln Arg Tyr Ala
                 165                 170                 175    





      <210> 1544
      <211> 885
      <212> PRT
      <213> Homo sapiens


      <400> 1544
 Met Gly Leu Trp Ala Gly Glu Gly Thr Leu Gln Trp Cys Leu Arg Leu
   1               5                  10                  15    
 Leu Leu Gln Lys Val Gly Gly Arg Pro Ala Thr Ser Trp Ser Thr Gly
              20                  25                  30        
 Arg Lys Gly Thr Glu Glu Gly Ile His Pro Tyr Val Thr Glu Ile Trp
          35                  40                  45            
 Ser Asn Leu Asn Gln Val Thr Lys Ser Val Ile Ser Ile Val Arg Arg
      50                  55                  60                
 Tyr Pro Leu Asp Ala Thr Ala Lys Leu Arg Glu Leu Asn Pro Asn Arg
  65                  70                  75                  80
 Glu Val Leu Arg Gly Asp His Ser Gln Lys Ser Leu Ser Pro Phe Ile
                  85                  90                  95    
 Tyr Ser Arg Ser Cys Phe Pro Asp Ala Leu Leu Leu Arg Ser Gly Ser
             100                 105                 110        
 Asp Leu Met Ala Gln Val Arg Glu Thr Ser Leu Pro Ser Gly Ser Gly
         115                 120                 125            
 Val Arg Trp Ile Ser Gly Gly Gly Gly Gly Ala Ser Pro Glu Glu Ala
     130                 135                 140                
 Val Glu Lys Ala Gly Lys Met Glu Glu Ala Ala Ala Gly Ala Thr Lys
 145                 150                 155                 160
 Ala Ser Ser Arg Arg Glu Ala Glu Glu Met Lys Leu Glu Pro Leu Gln
                 165                 170                 175    
 Glu Arg Glu Pro Ala Pro Glu Glu Asn Leu Thr Trp Ser Ser Ser Gly
             180                 185                 190        
 Gly Asp Glu Lys Val Leu Pro Ser Ile Pro Leu Arg Cys His Ser Ser
         195                 200                 205            
 Ser Ser Pro Val Cys Pro Arg Arg Lys Pro Arg Pro Arg Pro Gln Pro
     210                 215                 220                
 Arg Ala Arg Ser Arg Ser Gln Pro Gly Leu Ser Ala Pro Pro Pro Pro
 225                 230                 235                 240
 Pro Ala Arg Pro Pro Pro Pro Pro Pro Pro Pro Pro Pro Pro Ala Pro
                 245                 250                 255    
 Arg Pro Arg Ala Trp Arg Gly Ser Arg Arg Arg Ser Arg Pro Gly Ser
             260                 265                 270        
 Arg Pro Gln Thr Arg Arg Ser Cys Ser Gly Asp Leu Asp Gly Ser Gly
         275                 280                 285            
 Asp Pro Gly Gly Leu Gly Asp Trp Leu Leu Glu Val Glu Phe Gly Gln
     290                 295                 300                
 Gly Pro Thr Gly Cys Ser His Val Glu Ser Phe Lys Val Gly Lys Asn
 305                 310                 315                 320
 Trp Gln Lys Asn Leu Arg Leu Ile Tyr Gln Arg Phe Val Trp Ser Gly
                 325                 330                 335    
 Thr Pro Glu Thr Arg Lys Arg Lys Ala Lys Ser Cys Ile Cys His Val
             340                 345                 350        
 Cys Ser Thr His Met Asn Arg Leu His Ser Cys Leu Ser Cys Val Phe
         355                 360                 365            
 Phe Gly Cys Phe Thr Glu Lys His Ile His Lys His Ala Glu Thr Lys
     370                 375                 380                
 Gln His His Leu Ala Val Asp Leu Tyr His Gly Val Ile Tyr Cys Phe
 385                 390                 395                 400
 Met Cys Lys Asp Tyr Val Tyr Asp Lys Asp Ile Glu Gln Ile Ala Lys
                 405                 410                 415    
 Glu Thr Lys Glu Lys Ile Leu Arg Leu Leu Thr Ser Thr Ser Thr Asp
             420                 425                 430        
 Val Ser His Gln Gln Phe Met Thr Ser Gly Phe Glu Asp Lys Gln Ser
         435                 440                 445            
 Thr Cys Glu Thr Lys Glu Gln Glu Pro Lys Leu Val Lys Pro Lys Lys
     450                 455                 460                
 Lys Arg Arg Lys Lys Ser Val Tyr Thr Val Gly Leu Arg Gly Leu Ile
 465                 470                 475                 480
 Asn Leu Gly Asn Thr Cys Phe Met Asn Cys Ile Val Gln Ala Leu Thr
                 485                 490                 495    
 His Ile Pro Leu Leu Lys Asp Phe Phe Leu Ser Asp Lys His Lys Cys
             500                 505                 510        
 Ile Met Thr Ser Pro Ser Leu Cys Leu Val Cys Glu Met Ser Ser Leu
         515                 520                 525            
 Phe His Ala Met Tyr Ser Gly Ser Arg Thr Pro His Ile Pro Tyr Lys
     530                 535                 540                
 Leu Leu His Leu Ile Trp Ile His Ala Glu His Leu Ala Gly Tyr Arg
 545                 550                 555                 560
 Gln Gln Asp Ala His Glu Phe Leu Ile Ala Ile Leu Asp Val Leu His
                 565                 570                 575    
 Arg His Ser Lys Asp Asp Ser Gly Gly Gln Glu Ala Asn Asn Pro Asn
             580                 585                 590        
 Cys Cys Asn Cys Ile Ile Asp Gln Ile Phe Thr Gly Gly Leu Gln Ser
         595                 600                 605            
 Asp Val Thr Cys Gln Ala Cys His Ser Val Ser Thr Thr Ile Asp Pro
     610                 615                 620                
 Cys Trp Asp Ile Ser Leu Asp Leu Pro Gly Ser Cys Ala Thr Phe Asp
 625                 630                 635                 640
 Ser Gln Asn Pro Glu Arg Ala Asp Ser Thr Val Ser Arg Asp Asp His
                 645                 650                 655    
 Ile Pro Gly Ile Pro Ser Leu Thr Asp Cys Leu Gln Trp Phe Thr Arg
             660                 665                 670        
 Pro Glu His Leu Gly Ser Ser Ala Lys Ile Lys Cys Asn Ser Cys Gln
         675                 680                 685            
 Ser Tyr Gln Glu Ser Thr Lys Gln Leu Thr Met Lys Lys Leu Pro Ile
     690                 695                 700                
 Val Ala Cys Phe His Leu Lys Arg Phe Glu His Val Gly Lys Gln Arg
 705                 710                 715                 720
 Arg Lys Ile Asn Thr Phe Ile Ser Phe Pro Leu Glu Leu Asp Met Thr
                 725                 730                 735    
 Pro Phe Leu Ala Ser Thr Lys Glu Ser Arg Met Lys Glu Gly Gln Pro
             740                 745                 750        
 Pro Thr Asp Cys Val Pro Asn Glu Asn Lys Tyr Ser Leu Phe Ala Val
         755                 760                 765            
 Ile Asn His His Gly Thr Leu Glu Ser Gly His Tyr Thr Ser Phe Ile
     770                 775                 780                
 Arg Gln Gln Lys Asp Gln Trp Phe Ser Cys Asp Asp Ala Ile Ile Thr
 785                 790                 795                 800
 Lys Ala Thr Ile Glu Asp Leu Leu Tyr Ser Glu Gly Leu Gln Gly Ser
                 805                 810                 815    
 Phe Phe Asp Tyr Ser Pro Gly Gly Phe Tyr Ser Ser Phe Lys Thr Gln
             820                 825                 830        
 Leu Thr Asp Asp Phe Ser Gly Val Phe Pro Glu Cys Ser Arg Gln Gly
         835                 840                 845            
 Arg Ala Phe Cys Gln Pro Gln Leu Ser Lys Glu Leu Leu His Ser Gly
     850                 855                 860                
 Leu Ala Asp Leu Glu Gly Asn Ala Glu Ser Val Lys Ser Pro Lys Ala
 865                 870                 875                 880
 Lys Glu Pro Gly Val
                 885



      <210> 1545
      <211> 1465
      <212> PRT
      <213> Homo sapiens


      <400> 1545
 Met Ala Thr Pro Tyr Ser Ser Ser Leu Leu Ala Ala Ser Cys Cys Leu
   1               5                  10                  15    
 Asn Ser Val Ala Leu Ile Arg Thr Ser Leu Ala Thr Thr Asp Leu Leu
              20                  25                  30        
 Val Ala Arg Gln Pro His Asp His Gln Thr Arg Pro Gly Ser Pro His
          35                  40                  45            
 Cys His Arg Ala Pro Arg Pro Ser Ala Gly Met Lys Thr Arg Ser Ser
      50                  55                  60                
 Arg His Thr Gln Gly Ala Gln Pro Gly Leu Ala Asp Gln Ala Ala Lys
  65                  70                  75                  80
 Leu Ser Tyr Ala Ser Ala Glu Ser Leu Glu Thr Met Ser Glu Ala Glu
                  85                  90                  95    
 Leu Pro Leu Gly Phe Ser Arg Met Asn Arg Phe Arg Gln Ser Leu Pro
             100                 105                 110        
 Leu Ser Arg Ser Ala Ser Gln Thr Lys Leu Arg Ser Pro Ala Pro Lys
         115                 120                 125            
 Ser Ser Pro Arg Ser Pro Gly Gly Arg Arg Gly Asp Gly Ser Ser Asp
     130                 135                 140                
 Ser Glu Gly Gly Val Ser Phe Ala Gly Val Leu Phe Leu Gln Phe Gly
 145                 150                 155                 160
 Glu Glu Thr Arg Arg Val His Ile Thr His Glu Val Ser Ser Leu Asp
                 165                 170                 175    
 Thr Leu His Ala Leu Ile Ala His Met Phe Pro Gln Lys Leu Thr Met
             180                 185                 190        
 Gly Met Leu Lys Ser Pro Asn Thr Ala Ile Leu Ile Lys Asp Glu Ala
         195                 200                 205            
 Arg Asn Val Phe Tyr Glu Leu Glu Asp Val Arg Asp Ile Gln Asp Arg
     210                 215                 220                
 Ser Ile Ile Lys Ile Tyr Arg Lys Glu Pro Leu Tyr Ala Ala Phe Pro
 225                 230                 235                 240
 Gly Ser His Leu Thr Asn Gly Asp Leu Arg Arg Glu Met Val Tyr Ala
                 245                 250                 255    
 Ser Arg Glu Ser Ser Pro Thr Arg Arg Leu Asn Asn Leu Ser Pro Ala
             260                 265                 270        
 Pro His Leu Ala Ser Gly Ser Pro Pro Pro Gly Leu Pro Ser Gly Leu
         275                 280                 285            
 Pro Ser Gly Leu Gln Ser Gly Ser Pro Ser Arg Ser Arg Leu Ser Tyr
     290                 295                 300                
 Ala Gly Gly Arg Pro Pro Ser Tyr Ala Gly Ser Pro Val His His Ala
 305                 310                 315                 320
 Ala Glu Arg Leu Gly Gly Ala Pro Ala Ala Gln Gly Val Ser Pro Ser
                 325                 330                 335    
 Pro Ser Ala Ile Leu Glu Arg Arg Asp Val Lys Pro Asp Glu Asp Leu
             340                 345                 350        
 Ala Ser Lys Ala Gly Gly Met Val Leu Val Lys Gly Glu Gly Leu Tyr
         355                 360                 365            
 Ala Asp Pro Tyr Gly Leu Leu His Glu Gly Arg Leu Ser Leu Ala Ala
     370                 375                 380                
 Ala Ala Gly Asp Pro Phe Ala Tyr Pro Gly Ala Gly Gly Leu Tyr Lys
 385                 390                 395                 400
 Arg Gly Ser Val Arg Ser Leu Ser Thr Tyr Ser Ala Ala Ala Leu Gln
                 405                 410                 415    
 Ser Asp Leu Glu Asp Ser Leu Tyr Lys Ala Ala Gly Gly Gly Gly Pro
             420                 425                 430        
 Leu Tyr Gly Asp Gly Tyr Gly Phe Arg Leu Pro Pro Ser Ser Pro Gln
         435                 440                 445            
 Lys Leu Ala Asp Val Ala Ala Pro Pro Gly Gly Pro Pro Pro Pro His
     450                 455                 460                
 Ser Pro Tyr Ser Gly Pro Pro Ser Arg Gly Ser Pro Val Arg Gln Ser
 465                 470                 475                 480
 Phe Arg Lys Asp Ser Gly Ser Ser Ser Val Phe Ala Glu Ser Pro Gly
                 485                 490                 495    
 Gly Lys Thr Arg Ser Ala Gly Ser Ala Ser Thr Ala Gly Ala Pro Pro
             500                 505                 510        
 Ser Glu Leu Phe Pro Gly Pro Gly Glu Arg Ser Leu Val Gly Phe Gly
         515                 520                 525            
 Pro Pro Val Pro Ala Lys Asp Thr Glu Thr Arg Glu Arg Met Glu Ala
     530                 535                 540                
 Met Glu Lys Gln Ile Ala Ser Leu Thr Gly Leu Val Gln Ser Ala Leu
 545                 550                 555                 560
 Leu Arg Gly Ser Glu Pro Glu Thr Pro Ser Glu Lys Ile Glu Gly Ser
                 565                 570                 575    
 Asn Gly Ala Ala Thr Pro Ser Ala Pro Cys Gly Ser Gly Gly Arg Ser
             580                 585                 590        
 Ser Gly Ala Thr Pro Val Ser Gly Pro Pro Pro Pro Ser Ala Ser Ser
         595                 600                 605            
 Thr Pro Ala Gly Gln Pro Thr Ala Val Ser Arg Leu Gln Met Gln Leu
     610                 615                 620                
 His Leu Arg Gly Leu Gln Asn Ser Ala Ser Asp Leu Arg Gly Gln Leu
 625                 630                 635                 640
 Gln Gln Leu Arg Lys Leu Gln Leu Gln Asn Gln Glu Ser Val Arg Ala
                 645                 650                 655    
 Leu Leu Lys Arg Thr Glu Ala Glu Leu Ser Met Arg Val Ser Glu Ala
             660                 665                 670        
 Ala Arg Arg Gln Glu Asp Pro Leu Gln Arg Gln Arg Thr Leu Val Glu
         675                 680                 685            
 Glu Glu Arg Leu Arg Tyr Leu Asn Asp Glu Glu Leu Ile Thr Gln Gln
     690                 695                 700                
 Leu Asn Asp Leu Glu Lys Ser Val Glu Lys Ile Gln Arg Asp Val Ser
 705                 710                 715                 720
 His Asn His Arg Leu Val Pro Gly Pro Glu Leu Glu Glu Lys Ala Leu
                 725                 730                 735    
 Val Leu Lys Gln Leu Gly Glu Thr Leu Thr Glu Leu Lys Ala His Phe
             740                 745                 750        
 Pro Gly Leu Gln Ser Lys Met Arg Val Val Leu Arg Val Glu Val Glu
         755                 760                 765            
 Ala Val Lys Phe Leu Lys Glu Glu Pro Gln Arg Leu Asp Gly Leu Leu
     770                 775                 780                
 Lys Arg Cys Arg Gly Val Thr Asp Thr Leu Ala Gln Ile Arg Arg Gln
 785                 790                 795                 800
 Val Asp Glu Gly Val Trp Pro Pro Pro Asn Asn Leu Leu Ser Gln Ser
                 805                 810                 815    
 Pro Lys Lys Val Thr Ala Glu Thr Asp Phe Asn Lys Ser Val Asp Phe
             820                 825                 830        
 Glu Met Pro Pro Pro Ser Pro Pro Leu Asn Leu His Glu Leu Ser Gly
         835                 840                 845            
 Pro Ala Glu Gly Ala Ser Leu Thr Pro Lys Gly Gly Asn Pro Thr Lys
     850                 855                 860                
 Gly Leu Asp Thr Pro Gly Lys Arg Ser Val Asp Lys Ala Val Ser Val
 865                 870                 875                 880
 Glu Ala Ala Glu Arg Asp Trp Glu Glu Lys Arg Ala Ala Leu Thr Gln
                 885                 890                 895    
 Tyr Ser Ala Lys Asp Ile Asn Arg Leu Leu Glu Glu Thr Gln Ala Glu
             900                 905                 910        
 Leu Leu Lys Ala Ile Pro Asp Leu Asp Cys Ala Ser Lys Ala His Pro
         915                 920                 925            
 Gly Pro Ala Pro Thr Pro Asp His Lys Pro Pro Lys Ala Pro His Gly
     930                 935                 940                
 Gln Lys Ala Ala Pro Arg Thr Glu Pro Ser Gly Arg Arg Gly Ser Gly
 945                 950                 955                 960
 Ser Val Gln Pro Asp Pro Gly Leu Ala Ala Gln Arg Trp Gly Leu Ser
                 965                 970                 975    
 Cys Ser Ser Asp Lys Leu Pro Gly Ala Ala Ser Ala Ala Gly Pro Gln
             980                 985                 990        
 Thr Thr Leu Gly Val Ala Arg Val Leu Ser Gly Glu Gly Gln Gly Leu
         995                1000                1005            
 Gly Leu Val Cys Arg Arg Asp Glu Leu Thr Val Pro Arg Tyr Arg Thr
    1010                1015                1020                
 Glu Lys Pro Ser Lys Ser Pro Pro Pro Pro Pro Pro Arg Arg Ser Phe
1025                1030                1035                1040
 Pro Ser Ser His Gly Leu Thr Thr Thr Arg Thr Gly Glu Val Val Val
                1045                1050                1055    
 Thr Ser Lys Lys Asp Ser Ala Phe Ile Lys Lys Ala Glu Ser Glu Glu
            1060                1065                1070        
 Leu Glu Val Gln Lys Pro Gln Val Lys Leu Arg Arg Ala Val Ser Glu
        1075                1080                1085            
 Val Ala Arg Pro Ala Ser Thr Pro Pro Ile Met Ala Ser Ala Ile Lys
    1090                1095                1100                
 Asp Glu Asp Asp Glu Asp Arg Ile Ile Ala Glu Leu Glu Val Phe Glu
1105                1110                1115                1120
 Arg Ser Ser Val Ser Ser Leu Pro Pro Thr Pro Arg Arg Gln Leu Ile
                1125                1130                1135    
 Pro Thr Leu Leu Ser Pro Gln Asp Leu Gly Pro Pro Gly Gly Ser Ala
            1140                1145                1150        
 Pro Gly Pro Thr Arg Lys Ala Ala Pro Gly Pro Arg Ala Phe Cys Val
        1155                1160                1165            
 Pro Arg Ile Ile Leu Thr Glu Cys Ala Pro Asn Pro Pro Ser Pro Pro
    1170                1175                1180                
 Glu Ala Arg Leu Glu Glu Leu Gly Pro Arg Thr Ala Pro Thr Pro Arg
1185                1190                1195                1200
 Pro Gln Thr Leu Ala Asp Ser Thr Arg Gly Trp Asp Gly Pro Gln Ser
                1205                1210                1215    
 Pro Pro Gly Val Val Gly Glu Thr Ser Gly Pro Arg Ser Ser Phe Met
            1220                1225                1230        
 Pro Arg Lys Glu Gly Ala Ala Leu Lys Arg Leu Gly Gly Gly Gly Ser
        1235                1240                1245            
 Ser Leu Glu Asp Gly Gly Ala Arg Val Gln Cys Pro Gln Gly Pro Ala
    1250                1255                1260                
 Gln Asp Gly Thr Pro Glu Thr Ser Thr Ala Asp Thr Tyr Pro Glu Glu
1265                1270                1275                1280
 Ile Leu Lys Asp Ser Gly His Asp Ala Gln Thr Cys Ser Arg Glu His
                1285                1290                1295    
 Gln Gly Gln Ala Ala Ala Asn Ser Gly Arg Thr Thr Trp Gly Ala Thr
            1300                1305                1310        
 Ala Gln Gln Met Asp Ser Leu Glu Glu Thr Leu Arg Glu Leu Glu Ala
        1315                1320                1325            
 Thr Leu Ser Asn Met Gly Thr Gly Pro Ala Met Gly Ser Pro Gly Ser
    1330                1335                1340                
 Pro Pro Pro Leu Pro Leu Arg Pro Gln Ser Gly Gly Gly Ser Val Pro
1345                1350                1355                1360
 Pro Met Lys Val Val Thr Pro Gly Ala Ser Arg Leu Lys Ala Ala Gln
                1365                1370                1375    
 Gly Gln Ala Gly Ser Pro Asp Lys Ser Lys His Gly Lys Gln Arg Ala
            1380                1385                1390        
 Glu Tyr Met Arg Ile Gln Ala Gln Gln Gln Ala Pro Arg Met Arg Val
        1395                1400                1405            
 Ser Arg His Asn Ala Pro Pro Thr Thr Leu Pro Gln Pro Ala Thr Lys
    1410                1415                1420                
 Pro Ser Lys Glu Met Ser Gly Ser Asn Glu Thr Ser Ser Pro Val Ser
1425                1430                1435                1440
 Glu Lys Pro Ser Ala Ser Arg Thr Ser Ile Pro Val Leu Thr Ser Phe
                1445                1450                1455    
 Gly Ala Arg Asn Ser Ser Ile Ser Phe
            1460                1465



      <210> 1546
      <211> 661
      <212> PRT
      <213> Homo sapiens


      <400> 1546
 Met Trp Pro Leu Trp Arg Leu Val Ser Leu Leu Ala Leu Ser Gln Ala
   1               5                  10                  15    
 Leu Pro Phe Glu Gln Arg Gly Phe Trp Asp Phe Thr Leu Asp Asp Gly
              20                  25                  30        
 Pro Phe Met Met Asn Asp Glu Glu Ala Ser Gly Ala Asp Thr Ser Gly
          35                  40                  45            
 Val Leu Asp Pro Asp Ser Val Thr Pro Thr Tyr Ser Ala Met Cys Pro
      50                  55                  60                
 Phe Gly Cys His Cys His Leu Arg Val Val Gln Cys Ser Asp Leu Gly
  65                  70                  75                  80
 Leu Ser Leu Ser Asp Gly Glu Arg Gly Met Gln Gly Gly Ser Gly Leu
                  85                  90                  95    
 Glu Phe Met Leu Val Val Gly Val Gly Pro Leu Gly Leu Lys Phe Met
             100                 105                 110        
 Leu Val Met Gly Val Gly Pro Leu Gly Leu Lys Ser Val Pro Lys Glu
         115                 120                 125            
 Ile Ser Pro Asp Thr Thr Leu Leu Asp Leu Gln Asn Asn Asp Ile Ser
     130                 135                 140                
 Glu Leu Arg Lys Asp Asp Phe Lys Gly Leu Gln His Leu Tyr Ala Leu
 145                 150                 155                 160
 Val Leu Val Asn Asn Lys Ile Ser Lys Ile His Glu Lys Ala Phe Ser
                 165                 170                 175    
 Pro Leu Arg Lys Leu Gln Lys Leu Tyr Ile Ser Lys Asn His Leu Val
             180                 185                 190        
 Glu Ile Pro Pro Asn Leu Pro Ser Ser Leu Val Glu Leu Arg Ile His
         195                 200                 205            
 Asp Asn Arg Ile Arg Lys Val Pro Lys Gly Val Phe Ser Gly Leu Arg
     210                 215                 220                
 Asn Met Asn Cys Ile Glu Met Gly Gly Asn Pro Leu Glu Asn Ser Gly
 225                 230                 235                 240
 Phe Glu Pro Gly Ala Phe Asp Gly Leu Lys Leu Asn Tyr Leu Arg Ile
                 245                 250                 255    
 Ser Glu Ala Lys Leu Thr Gly Ile Pro Lys Asp Leu Pro Glu Thr Leu
             260                 265                 270        
 Asn Glu Leu His Leu Asp His Asn Lys Ile Gln Ala Ile Glu Leu Glu
         275                 280                 285            
 Asp Leu Leu Arg Tyr Ser Lys Leu Tyr Arg Leu Gly Leu Gly His Asn
     290                 295                 300                
 Gln Ile Arg Met Ile Glu Asn Gly Ser Leu Ser Phe Leu Pro Thr Leu
 305                 310                 315                 320
 Arg Glu Leu His Leu Asp Asn Asn Lys Leu Ala Arg Val Pro Ser Gly
                 325                 330                 335    
 Leu Pro Asp Leu Lys Leu Leu Gln Val Val Tyr Leu His Ser Asn Asn
             340                 345                 350        
 Ile Thr Lys Val Gly Val Asn Asp Phe Cys Pro Met Gly Phe Gly Val
         355                 360                 365            
 Lys Arg Ala Tyr Tyr Asn Gly Ile Ser Leu Phe Asn Asn Pro Val Pro
     370                 375                 380                
 Tyr Trp Glu Val Gln Pro Ala Thr Phe Arg Cys Val Thr Asp Arg Leu
 385                 390                 395                 400
 Ala Ile Gln Phe Gly Asn Tyr Lys Asn Val Lys Met Asn His Ile Ala
                 405                 410                 415    
 Ser Leu Tyr Arg Gln Val Trp Glu Lys Leu Leu Ala Asn Thr Ser Gln
             420                 425                 430        
 Gly Lys Lys Glu Phe Glu Ala Ala Ser Arg Pro Leu Ala Pro Ala Ser
         435                 440                 445            
 Gly Ser Arg Pro Glu Pro Leu Pro Val Pro Gln Arg Ala Phe Ser Ala
     450                 455                 460                
 Arg Cys Ser Glu Cys Ser Gln Arg Pro Ala Leu Gly Ser Glu Ala Ser
 465                 470                 475                 480
 Thr Ala Pro Gly Ala Gly Lys Pro Gly Gly Pro Pro Ala Gly Thr Gly
                 485                 490                 495    
 Val Ser Phe Gln Ala Phe Pro Ser Leu Glu Arg Ile Val Ala Arg Leu
             500                 505                 510        
 Thr Pro Ala Arg Ser Asp Ser Ala Arg Arg Ser Arg Gly Arg Gly Gly
         515                 520                 525            
 Gly Arg Ala His Ala Arg Glu Arg Leu Ser Pro Pro Pro Arg Leu Cys
     530                 535                 540                
 Asp Leu Gly Gln Pro Ala Phe Pro Val Ala Ala Cys Val Phe Ser Arg
 545                 550                 555                 560
 Val Lys Ala Leu Ala Leu Arg Phe Trp Asn Leu Glu Trp Gln Asn Gly
                 565                 570                 575    
 Ala Ser Tyr Ala Arg Gly Pro His Leu Ile Asp Val Met Gly Met Arg
             580                 585                 590        
 Asp Thr Ala Leu Val His Cys Val Pro Gly Ser Val Phe Ala Ser Gly
         595                 600                 605            
 Glu Thr Thr Glu Ser Lys Lys Gln Thr Gln Cys Pro Ser Cys Pro Pro
     610                 615                 620                
 Gly Ala Phe Val Leu Cys Ser Val Phe Thr Lys Ile Ser Gln Leu Ser
 625                 630                 635                 640
 Tyr Glu Ala Leu Thr Gly Val Glu Ser Tyr Ser Val Gly Leu Ser Val
                 645                 650                 655    
 Thr Gly Ser Phe Tyr
             660    



      <210> 1547
      <211> 733
      <212> PRT
      <213> Homo sapiens


      <400> 1547
 Met Ala Ala Trp Pro Arg Ile Ser Leu Ala Gly Pro Val Ser Val Ala
   1               5                  10                  15    
 Gln Ser Leu Leu Ala Pro Glu Arg Gly Leu Ala Cys Ala Ser Val Asp
              20                  25                  30        
 Val Cys Ser Arg Val Gly Val Phe Leu Trp Ala Gly Ser Thr Ala Asp
          35                  40                  45            
 Ala Pro Lys Glu Gly Arg Leu Thr Arg Phe Leu Asp Phe Thr Gln Leu
      50                  55                  60                
 Met Asp Met Ala Ser Glu Ser Val Gly Gly Lys Leu Ala Gly Glu Gln
  65                  70                  75                  80
 Leu Ala Gly Arg Asp Glu Val Gln Gly Gly Ser Gly Arg Gly Val Cys
                  85                  90                  95    
 Glu Glu Ser Lys Gly Ala His Met Leu Gln Val Ala Gln Cys Phe Lys
             100                 105                 110        
 Asn Thr Leu Arg Val Cys Glu Lys Ser Trp Glu His Glu Ser Gly Glu
         115                 120                 125            
 Ser Asp Ser Pro Cys Phe Lys Glu His Glu Tyr Thr Glu Phe Gly Lys
     130                 135                 140                
 Trp Met Asp Gly Trp Glu Thr Arg Arg Lys Arg Ile Pro Gly His Asp
 145                 150                 155                 160
 Trp Cys Val Leu Arg Leu Gly Ile Gln Gly Val Ile Arg Gly Phe Asp
                 165                 170                 175    
 Val Asp Val Ser Tyr Phe Thr Gly Asp Tyr Ala Pro Arg Val Ser Ile
             180                 185                 190        
 Gln Ala Ala Asn Leu Glu Glu Asp Lys Leu Pro Glu Ile Pro Glu Arg
         195                 200                 205            
 Gly Thr Arg Thr Gly Ala Ala Ala Thr Pro Glu Glu Phe Glu Ala Ile
     210                 215                 220                
 Ala Glu Leu Lys Ser Asp Asp Trp Ser Tyr Leu Val Pro Met Thr Glu
 225                 230                 235                 240
 Leu Lys Pro Gly Asn Pro Ala Ser Gly His Asn Tyr Phe Leu Val Asn
                 245                 250                 255    
 Ser Gln Gln Arg Trp Thr His Ile Arg Leu Asn Ile Phe Pro Asp Asn
             260                 265                 270        
 Asp Gly Ile Ser Ile Asp Val Ser Leu Leu Ile Leu Ser Leu Asp Asp
         275                 280                 285            
 Thr Val Glu Leu Ala Met Gly Gly Ser Leu Leu Glu His Val Gly Gln
     290                 295                 300                
 Val Val Glu Val Asn Glu Gly Ile Ile Asp Asp Asp Asn Ile His Phe
 305                 310                 315                 320
 Ala Arg Ala Lys Ser Ser Leu Gly Asp Gln Arg Arg Tyr Lys Ser Gly
                 325                 330                 335    
 Thr Glu Val Asn Asn Thr Asp Gly Gly Ile Ala Arg Leu Arg Val Phe
             340                 345                 350        
 Gly Thr Gly Gln Lys Asp Trp Thr Ala Thr Asp Pro Lys Glu Pro Ala
         355                 360                 365            
 Asp Leu Val Ala Ile Ala Phe Gly Gly Val Cys Val Gly Phe Ser Asn
     370                 375                 380                
 Ala Lys Phe Gly His Pro Asn Asn Ile Ile Gly Asn Ala Pro Asp Ser
 385                 390                 395                 400
 Cys Lys Val Asp Gly Cys Ile Leu Thr Thr Gln Glu Glu Glu Ala Val
                 405                 410                 415    
 Ile Arg Gln Lys Trp Ile Leu Pro Ala His Lys Trp Lys Pro Leu Leu
             420                 425                 430        
 Pro Val Thr Lys Leu Ser Pro Asn Gln Ser His Leu Phe Asp Ser Leu
         435                 440                 445            
 Thr Leu Glu Leu Gln Asp Val Ile Thr His Ala Arg Leu Thr Ile Val
     450                 455                 460                
 Pro Asp Gly Gly Val Ser Arg Leu Arg Leu Arg Gly Phe Pro Ser Ser
 465                 470                 475                 480
 Ile Cys Leu Leu Arg Pro Arg Glu Lys Pro Met Leu Lys Phe Ser Pro
                 485                 490                 495    
 Leu Ala Leu Ala Ala Arg Arg Ser Gln Ser Pro Arg Val Ala Ser Thr
             500                 505                 510        
 Arg Ser Leu Arg Pro Pro Gly Ser Pro Val Pro Ser Pro Ser Ser Pro
         515                 520                 525            
 Arg Pro Val Pro Val Pro Ser Pro Ser Cys Ala Ser Gly Trp Ser Gly
     530                 535                 540                
 Pro Pro Val Gly Gly Ala Arg Ala Trp Ala Arg Leu Cys Arg Arg Arg
 545                 550                 555                 560
 Cys Pro Arg Cys Arg Ser Leu Ser Ala Pro Ala Ser Glu Glu Arg Gly
                 565                 570                 575    
 Ala Ala Met Gly Thr Arg Gly Pro Ser Ala Pro Val Asp Thr Thr Pro
             580                 585                 590        
 Ala Lys Thr Ile Val Val Tyr Arg Asn Gly Asp Pro Phe Tyr Val Gly
         595                 600                 605            
 Lys Lys Phe Val Leu Ser Arg Arg Arg Ala Ala Thr Phe Glu Ala Leu
     610                 615                 620                
 Leu Glu Gln Leu Thr Glu Gln Val Asp Val Pro Phe Gly Val Arg Arg
 625                 630                 635                 640
 Leu Phe Thr Pro Thr Arg Gly His Arg Val Leu Gly Leu Asp Ala Leu
                 645                 650                 655    
 Gln Ala Gly Gly Lys Tyr Val Ala Ala Gly Arg Glu Arg Phe Lys Glu
             660                 665                 670        
 Leu Asp Tyr Ile His Ile Val Pro Arg Lys Pro Ala Lys Ile Arg Lys
         675                 680                 685            
 Leu Lys Glu Lys Arg Leu Phe Ser Val Ser Leu Glu His His Pro Glu
     690                 695                 700                
 Leu His Ala Gly His Ala Ser Ser Pro Ser Ile Val His Arg His Gln
 705                 710                 715                 720
 Leu Pro Glu Ala Phe Arg Cys Leu Leu Gly Val Cys Pro
                 725                 730            



      <210> 1548
      <211> 186
      <212> PRT
      <213> Homo sapiens


      <400> 1548
 Met Pro Leu Asn Leu Gly Ser Gly Tyr Phe Gly Val Leu Cys Ile Phe
   1               5                  10                  15    
 Glu Leu Met Phe Tyr Thr Lys Asn Leu Val Asn Gly Ser Asn Ser Ser
              20                  25                  30        
 Arg Arg Val Ser Ser Ile Ser Val Thr Pro Ala Phe Lys Pro Phe Asn
          35                  40                  45            
 Val Ile Ala Leu Glu Phe Ala Ile His Ile Tyr Lys Glu Ser Asn Pro
      50                  55                  60                
 Thr Phe Lys Glu His Tyr Thr Thr Ser His Val Val Glu Asn Leu Arg
  65                  70                  75                  80
 Lys Phe Tyr Lys Gly Lys Lys Tyr Gln Pro Val Asp Leu Gln Pro Lys
                  85                  90                  95    
 Lys Thr Cys Ala Met Ser His Cys Leu Asn Lys His Glu Glu Asn Leu
             100                 105                 110        
 Lys Gly Lys Lys Gln Gln Trp Lys Glu Trp Leu Ser Pro Leu Arg Lys
         115                 120                 125            
 Glu Glu Gly Ala Pro Val Pro Ala Glu Glu Val His Val Ser Glu Ala
     130                 135                 140                
 Pro Pro Pro Ala Pro Ala Phe Thr Thr Asn Lys Trp Trp Val Lys Glu
 145                 150                 155                 160
 Ser Lys Thr Tyr Ile Phe Gly His Arg Val Lys Glu Ala Ser Tyr Gln
                 165                 170                 175    
 Leu Trp Met Asn Glu Thr Arg Gly Ala Cys
             180                 185    



      <210> 1549
      <211> 101
      <212> PRT
      <213> Homo sapiens


      <400> 1549
 Met Gly Phe Glu Leu Leu Ser Val Leu Leu Pro Arg Ser Phe Cys Gln
   1               5                  10                  15    
 Leu Gln Thr Phe Lys Asp Ser Val Phe Gly Leu Glu Asn Arg Ser Pro
              20                  25                  30        
 Lys Asp Val Met Phe Gln Ala Ser Pro Tyr Pro Ser Asp Gln Gln Leu
          35                  40                  45            
 Asp Cys Ala Leu Asp Leu Met Arg Arg Leu Pro Pro Gln Gln Ile Glu
      50                  55                  60                
 Lys Asn Leu Ser Asp Leu Ile Asp Leu Val Thr Arg Gly Trp Leu Thr
  65                  70                  75                  80
 Leu Asn Ala Ala Val Phe Thr Ile Leu Ser Thr Gly Lys Lys Leu Leu
                  85                  90                  95    
 Ser Leu Arg Ser Gly
             100    



      <210> 1550
      <211> 143
      <212> PRT
      <213> Homo sapiens


      <400> 1550
 Met Ser Ser Leu Gly Ser Ser Phe Leu Tyr Ala Leu Ser Leu Phe Ala
   1               5                  10                  15    
 Glu Ser Ser Asn Ala Thr Leu Leu Thr Asn Ala Glu Lys Ile Ala Thr
              20                  25                  30        
 Ile Thr Thr Thr His Thr Pro Ser Gln Gln Gly Thr Gln Glu Thr Arg
          35                  40                  45            
 Asn Thr Thr Lys Pro Lys Gln Glu Ser Gln Phe Glu Phe Lys Ala Pro
      50                  55                  60                
 Gln Ala Thr Gln Glu Gln Asp Phe Tyr Thr Val Glu Leu Glu Arg Gly
  65                  70                  75                  80
 Ala Lys Gly Phe Gly Phe Ser Leu Arg Gly Gly Arg Glu Tyr Asn Met
                  85                  90                  95    
 Asp Leu Tyr Val Leu Arg Leu Ala Glu Asp Gly Pro Ala Glu Arg Cys
             100                 105                 110        
 Gly Lys Met Arg Leu Val Thr Ser Gly Leu Thr Leu Gly Ser Glu Thr
         115                 120                 125            
 Ala Ser Leu Leu Ser Ala Leu Ala Lys Ser Gln Gly Ser Val Ala
     130                 135                 140            



      <210> 1551
      <211> 597
      <212> PRT
      <213> Homo sapiens


      <400> 1551
 Met Ser Asn Thr Lys Leu Leu Ala Gly Gly Ser Phe Ser Met Ala Ser
   1               5                  10                  15    
 Trp Trp Pro Leu Leu Pro Val Ser Leu Leu Lys Thr Ala Ser Leu Tyr
              20                  25                  30        
 Val Ser Met Ser Met Cys Pro Pro Ile Val Ser Thr Gln Glu Lys Glu
          35                  40                  45            
 Leu Val Gln Pro Phe Ser Ser Leu Phe Pro Lys Val Glu Tyr Ile Ala
      50                  55                  60                
 Arg Ala Gly Trp Thr Arg Asp Gly Lys Tyr Ala Trp Ala Met Phe Leu
  65                  70                  75                  80
 Asp Arg Pro Gln Gln Trp Leu Gln Leu Val Leu Leu Pro Pro Ala Leu
                  85                  90                  95    
 Phe Ile Pro Ser Thr Glu Asn Glu Glu Gln Arg Leu Ala Ser Ala Arg
             100                 105                 110        
 Ala Val Pro Arg Asn Val Gln Pro Tyr Val Val Tyr Glu Glu Val Thr
         115                 120                 125            
 Asn Val Trp Ile Asn Val His Asp Ile Phe Tyr Pro Phe Pro Gln Ser
     130                 135                 140                
 Glu Gly Glu Asp Glu Leu Cys Phe Leu Arg Ala Asn Glu Cys Lys Thr
 145                 150                 155                 160
 Gly Phe Cys His Leu Tyr Lys Val Thr Ala Val Leu Lys Ser Gln Gly
                 165                 170                 175    
 Tyr Asp Trp Ser Glu Pro Phe Ser Pro Gly Glu Asp Glu Phe Lys Cys
             180                 185                 190        
 Pro Ile Lys Glu Glu Ile Ala Leu Thr Ser Gly Glu Trp Glu Val Leu
         195                 200                 205            
 Ala Arg His Gly Ser Lys Ala Ser Ala Lys Ala Cys Ser Leu Leu Gly
     210                 215                 220                
 Ser Ser Ser Cys Phe Glu Thr Ile Ser Ile Pro Ala Gln Ile Trp Val
 225                 230                 235                 240
 Asn Glu Glu Thr Lys Leu Val Tyr Phe Gln Gly Thr Lys Asp Thr Pro
                 245                 250                 255    
 Leu Glu His His Leu Tyr Val Val Ser Tyr Glu Ala Ala Gly Glu Ile
             260                 265                 270        
 Val Arg Leu Thr Thr Pro Gly Phe Ser His Ser Cys Ser Met Ser Gln
         275                 280                 285            
 Asn Phe Asp Met Phe Val Ser His Tyr Ser Ser Val Ser Thr Pro Pro
     290                 295                 300                
 Cys Val His Val Tyr Lys Leu Ser Gly Pro Asp Asp Asp Pro Leu His
 305                 310                 315                 320
 Lys Gln Pro Arg Phe Trp Ala Ser Met Met Glu Ala Ala Ser Cys Pro
                 325                 330                 335    
 Pro Asp Tyr Val Pro Pro Glu Ile Phe His Phe His Thr Arg Ser Asp
             340                 345                 350        
 Val Arg Leu Tyr Gly Met Ile Tyr Lys Pro His Ala Leu Gln Pro Gly
         355                 360                 365            
 Lys Lys His Pro Thr Val Leu Phe Val Tyr Gly Gly Pro Gln Val Gln
     370                 375                 380                
 Leu Val Asn Asn Ser Phe Lys Gly Ile Lys Tyr Leu Arg Leu Asn Thr
 385                 390                 395                 400
 Leu Ala Ser Leu Gly Tyr Ala Val Val Val Ile Asp Gly Arg Gly Ser
                 405                 410                 415    
 Cys Gln Arg Gly Leu Arg Phe Glu Gly Ala Leu Lys Asn Gln Met Gly
             420                 425                 430        
 Gln Val Glu Ile Glu Asp Gln Val Glu Gly Leu Gln Phe Val Ala Glu
         435                 440                 445            
 Lys Tyr Gly Phe Ile Asp Leu Ser Arg Val Ala Ile His Gly Trp Ser
     450                 455                 460                
 Tyr Gly Gly Phe Leu Ser Leu Met Gly Leu Ile His Lys Pro Gln Val
 465                 470                 475                 480
 Phe Lys Val Ala Ile Ala Gly Ala Pro Val Thr Val Trp Met Ala Tyr
                 485                 490                 495    
 Asp Thr Gly Tyr Thr Glu Arg Tyr Met Asp Val Pro Glu Asn Asn Gln
             500                 505                 510        
 His Gly Tyr Glu Ala Gly Ser Val Ala Leu His Val Glu Lys Leu Pro
         515                 520                 525            
 Asn Glu Pro Asn Arg Leu Leu Ile Leu His Gly Phe Leu Asp Glu Asn
     530                 535                 540                
 Val His Phe Phe His Thr Asn Phe Leu Val Ser Gln Leu Ile Arg Ala
 545                 550                 555                 560
 Gly Lys Pro Tyr Gln Leu Gln Ile Tyr Pro Asn Glu Arg His Ser Ile
                 565                 570                 575    
 Arg Cys Pro Glu Ser Gly Glu His Tyr Glu Val Thr Leu Leu His Phe
             580                 585                 590        
 Leu Gln Glu Tyr Leu
         595        



      <210> 1552
      <211> 290
      <212> PRT
      <213> Homo sapiens


      <400> 1552
 Met Ser His Ala Leu Ala Leu Leu Ala Ser Thr Trp Ala Pro Thr Ala
   1               5                  10                  15    
 Arg Pro Pro Gln Ser Phe Thr Gln Ala Ile Ala Asp Cys Arg Cys Met
              20                  25                  30        
 Leu Glu Met Gly His Arg Ala Gly His Asp Met Ser Cys Leu Asp Ile
          35                  40                  45            
 Gly Gly Gly Phe Pro Gly Met Glu Gly Ser Gly Pro Lys Phe Glu Glu
      50                  55                  60                
 Val Ser Trp Asp Asn Ser Asn Ala Tyr Leu Gln Gly Ala Ser Gly Met
  65                  70                  75                  80
 Lys Gly Leu Met Gln Leu Ala Arg Val Ile Ser Ala Ala Leu Ala Gln
                  85                  90                  95    
 Asp Leu Pro Glu Glu Arg Gly Val Lys Val Ile Ala Glu Pro Gly Cys
             100                 105                 110        
 Phe Tyr Val Glu Ser Val Cys Met Ala Ala Val Asn Ile Ile Ala Lys
         115                 120                 125            
 Arg Ala Val Leu Glu Pro Gly Val Leu Leu Arg Ala Ala Pro Leu Pro
     130                 135                 140                
 Leu His Pro Leu Cys Pro Met Cys Asp Ala Phe Asp Arg Leu Phe Leu
 145                 150                 155                 160
 Glu Asp Val Arg Leu Pro Glu Leu Asp Val Gly Asp Trp Leu Val Phe
                 165                 170                 175    
 Pro Ser Met Gly Ala Tyr Met Ser Ser Met Ser Ser Ser Phe Asn Gly
             180                 185                 190        
 Phe Leu Pro Ala Thr Ile Cys Tyr Thr Met Gly Pro Gln Leu Ser Gln
         195                 200                 205            
 Val Leu Gly Asp Pro Arg Val Pro Gly Ala Glu Glu Glu Leu Pro Leu
     210                 215                 220                
 Thr Cys Gly Lys Gln Arg Ala Asp Trp Gly Asn Arg Gly His Ser Glu
 225                 230                 235                 240
 Lys Leu Glu Glu Leu Asn Ser Pro Ser Ser Gln Val His Leu Met Arg
                 245                 250                 255    
 Ala Ser Gln Asn Ile Lys Phe Pro Ala Cys Lys Met Val Leu Leu Met
             260                 265                 270        
 Pro Lys His Ser Glu Tyr Lys Lys His Gly Leu Trp Val Arg Tyr Leu
         275                 280                 285            
 Gly Val
     290



      <210> 1553
      <211> 135
      <212> PRT
      <213> Homo sapiens


      <400> 1553
 Met Pro Ala Ser Phe Phe Ser Leu Ala Phe Tyr Gln Ser Val Leu Ala
   1               5                  10                  15    
 His Glu Leu Lys Val Thr Gln Ile Ile Ser Gly Ser Ala Arg Ile Gln
              20                  25                  30        
 Thr Gln Thr Asp Trp Leu Gln Gly His Ala Arg Asp Arg Leu Val Ala
          35                  40                  45            
 Val Ile His Ile Gly Leu Gln Val Met Ile Trp Val Tyr Val Glu Gly
      50                  55                  60                
 Gly Val Arg Glu Thr Cys Gly Tyr Val Leu Val Phe His Cys Phe Lys
  65                  70                  75                  80
 Thr Phe Ser Leu Ile Phe His Leu Phe Pro Pro Ala Ser Glu Thr Cys
                  85                  90                  95    
 Asn Asp Phe His Pro Met Phe Phe Thr His Asp Arg Ser Phe Glu Glu
             100                 105                 110        
 Phe Phe Cys Ile Cys Ile Gln Leu Leu Ile Pro Leu Gly Val Arg Leu
         115                 120                 125            
 Glu Gln Leu Cys Ser Phe Val
     130                 135



      <210> 1554
      <211> 377
      <212> PRT
      <213> Homo sapiens


      <400> 1554
 Met Ser Thr Trp Asn Trp Leu Ser Cys Leu Ala Leu Ser Leu Thr Leu
   1               5                  10                  15    
 Ala Pro Lys His Thr Gly Ser Glu Arg Leu Cys Phe Val Met Phe Trp
              20                  25                  30        
 Thr Pro Asn Val Ser Glu Lys Ile Leu Ile Asp Ile Ile Gly Val Asp
          35                  40                  45            
 Phe Ala Phe Ala Glu Leu Cys Val Val Pro Leu Arg Ile Phe Ser Phe
      50                  55                  60                
 Phe Pro Val Pro Val Pro Arg Cys Pro Pro Met Ala Leu Leu Gln Leu
  65                  70                  75                  80
 Arg Asp Pro Val Lys Arg Gln Ala Trp Ala Gly His Ala Ala Leu Gly
                  85                  90                  95    
 Glu Met Ala Ala His Gln Arg Gly Pro Thr Pro Leu Gly Gly Arg Lys
             100                 105                 110        
 Gly Ser Asp Leu Gly Gly Ser Gly Gln Asp Gln Ser Arg Glu Arg Thr
         115                 120                 125            
 Glu Gly Ser Gly Asp Glu Gln Leu Pro Pro Pro Thr Pro Leu Leu Gly
     130                 135                 140                
 Pro His Thr Ser Asp Arg Arg Gln Gly Arg Trp Leu Leu Met Pro Ala
 145                 150                 155                 160
 Phe Leu Leu Thr Gln His His Thr Arg Val Pro Leu Phe Ser Glu Cys
                 165                 170                 175    
 Ser Leu Leu Glu Val Asp Asp Gln Arg Ala Arg Leu Ala Lys Cys Gly
             180                 185                 190        
 Asp Arg Thr Gly Gln Glu Gln Leu Gly Cys Leu Glu Asp Ala Val Pro
         195                 200                 205            
 Val Glu Lys Gly Ala Cys Leu Arg Gln Gln Asp Gly Glu Trp Met Ala
     210                 215                 220                
 Gly Thr Ala Asp Glu Ser Phe Ala Pro Pro Asn Ser His Ser Glu Gly
 225                 230                 235                 240
 Ala Ser His Arg Val Ala Asp Asp Thr Glu Glu Asn Leu Arg Pro Cys
                 245                 250                 255    
 Pro Gln Leu Cys Ala Ala Asp His Arg Pro His Arg Gln Pro Arg Gly
             260                 265                 270        
 Pro Thr Leu Pro Gly Thr Asn Cys Leu Cys Val Leu Ile Cys Arg Val
         275                 280                 285            
 His Gly Ala Thr Leu Gly Val Gly Ser Leu Leu Ala Gly Phe Val Gly
     290                 295                 300                
 Glu Ser Thr Met Val Ala Ile Ala Ala Cys Tyr Val Tyr Arg Lys Gln
 305                 310                 315                 320
 Thr Cys Asp Ala Ala Asp Gly Arg Gly Asp Ser Asp Thr Asn Val Ala
                 325                 330                 335    
 Val His Thr Arg Thr Gly Gln Ser Lys Thr Gly Ala Arg Ala Ala Ser
             340                 345                 350        
 Leu Val Met Gly Gly Ala Glu Met Gln Ser Glu Ser Leu Arg Lys Gly
         355                 360                 365            
 Leu Ser Asp His Phe Cys Phe Ser Gln
     370                 375        



      <210> 1555
      <211> 898
      <212> PRT
      <213> Homo sapiens


      <400> 1555
 Met Ile Lys Ile Arg Asp Leu Ser Pro Lys Arg Gln Phe Leu Ala Leu
   1               5                  10                  15    
 Leu Leu Cys Leu Phe Pro Ser Ser Leu Ser Ser Arg Gly Ser Lys Arg
              20                  25                  30        
 Leu Glu Lys Arg Glu Lys Gly Cys Arg Glu Arg Glu Asn Gly Ser Glu
          35                  40                  45            
 Arg Ala Leu Ile Asp Ser Gln Phe Ser Met Asp Gly Gln Ala Ala Gly
      50                  55                  60                
 Asn Leu Gln Ser Arg Trp Asn Glu Lys Gly Lys Gln Ser Thr Phe Phe
  65                  70                  75                  80
 Thr Arg Gln Gln Glu Glu Val Pro Ser Glu Ala Gly Glu Glu Pro Leu
                  85                  90                  95    
 Ile Lys Pro Ser Asp Leu Cys Arg Ile Leu Asp Gly Gly Leu Lys Pro
             100                 105                 110        
 Ser Val Ser Lys Pro Pro Gly Asn Leu Ile Lys Asp Pro Arg Ser Arg
         115                 120                 125            
 Thr Leu Ser His Thr Cys Ala Ile Arg Leu Leu Arg Leu Arg Gln Gly
     130                 135                 140                
 Ser Ser Cys Leu Ala Ser Phe Pro Glu Thr Leu Asp Pro Val Thr Arg
 145                 150                 155                 160
 Arg Asn Trp Gln Trp Ser Pro Phe Pro Asp Lys Arg Met Asn Glu Glu
                 165                 170                 175    
 Ala Val Phe Ser Phe Leu Pro Arg Trp Trp Leu Ser Cys Pro Lys Thr
             180                 185                 190        
 Met Lys Cys Thr Lys Gln Glu Thr Gly Gly Leu Val Gln Ala Val Thr
         195                 200                 205            
 Gln Thr Leu Trp Val Lys Arg Ser Pro Phe Ile Tyr Leu Gly Ala His
     210                 215                 220                
 Ile Asn Gln Leu Asn Gly Arg Ile Ala Val Asn Asp Trp Glu Lys Gln
 225                 230                 235                 240
 Ile Phe Glu Lys Gln Asn Ile Cys Asn Thr Thr Ser Leu Arg Ser Lys
                 245                 250                 255    
 Lys Ser Val Ile Ile Gly His Ser Arg Pro Pro Thr Leu His Ala Ile
             260                 265                 270        
 Cys Asp Gln Ala Leu Ser Ser Pro Leu Arg Ala Ser Pro Phe Thr Leu
         275                 280                 285            
 Pro Gly Pro Gln Gly Arg Val Val Leu Ser Ile Asn Lys His Lys Gly
     290                 295                 300                
 Met Pro Leu Ser Gly His Pro Ala Glu Pro His Ser Ser Ala Pro Ser
 305                 310                 315                 320
 Asn His Phe Leu Ser Trp Gly Leu Ser Pro Lys Thr Asp Gln Arg Arg
                 325                 330                 335    
 Cys Leu Met Lys Asp Ala His Thr Ile Leu Val Cys Ser Leu Asp Ile
             340                 345                 350        
 Pro Ala Asn Gly Thr Val Val Thr Gly Asn Asp Lys Gln Met Pro Leu
         355                 360                 365            
 Asp Pro Cys Cys Pro Gln Gly His Leu Asn Phe Lys Thr Thr Tyr Asn
     370                 375                 380                
 Ser Leu Asn Asp Asn Ser Met Gln Phe Gln His Pro Thr His Ile Cys
 385                 390                 395                 400
 His Lys Pro Phe Val Phe Asn Gln Val Arg Lys Asn Leu Leu Glu Phe
                 405                 410                 415    
 Thr Val Leu Ser Arg Arg Asn Trp Gln Ile Ile Asn Lys Ile Ser Leu
             420                 425                 430        
 Glu Lys Phe Ser Val Asp Pro His Ser His Pro His Ser Phe Val Leu
         435                 440                 445            
 Gln Cys Phe Arg Thr Cys Leu Leu Glu Cys Gly Arg Ile Ile Cys Leu
     450                 455                 460                
 Gln Val Lys Ala Ala Phe Phe Thr Glu Thr Cys Thr Lys Val Leu Asn
 465                 470                 475                 480
 Lys Leu Val Cys Cys Ser Lys Gly Asp Leu Leu Arg Gln Gln Leu Pro
                 485                 490                 495    
 Lys Asp Ile Leu Arg Thr Ser Ala Lys Ser Leu Leu Trp Gln Asp Gln
             500                 505                 510        
 Asp Leu Ala Asn Pro Ser Asp Pro Thr Gln Glu Lys Pro His Arg Arg
         515                 520                 525            
 Pro Arg Arg Ser Lys Ala Met Asp Gln Ala Glu Lys Leu Arg Leu Gly
     530                 535                 540                
 Glu Lys Arg Arg Ala His Arg Leu Gln Leu Ala Glu Pro Thr Ala Asp
 545                 550                 555                 560
 Leu Ile Phe Leu Pro Gly Asn Ser Ser Ile Asp Leu Ser Arg Glu Pro
                 565                 570                 575    
 Ile Phe Ala Gln Ala Gly Pro Val Pro Val Ala Leu Gly Thr Gln Tyr
             580                 585                 590        
 His Pro Gly Arg Phe Phe Leu Val Gln Thr Val Ile Ile Pro Phe Met
         595                 600                 605            
 Tyr Val Arg Asn Pro Lys Ala Val Leu Gln Val Leu Ala Arg Ala Ile
     610                 615                 620                
 Arg Gln Glu Lys Glu Ile Lys Gly Ile Gln Leu Gly Lys Glu Glu Val
 625                 630                 635                 640
 Lys Leu Ser Leu Phe Ala Asp Asp Met Ile Val Tyr Leu Glu Asn Pro
                 645                 650                 655    
 Thr Val Ser Ala Gln Asn Leu Leu Lys Leu Ile Gly Asn Phe Ser Lys
             660                 665                 670        
 Val Ser Gly Tyr Lys Ile Asn Val Gln Lys Ser Gln Ala Phe Leu Tyr
         675                 680                 685            
 Thr Asn Asn Arg Gln Thr Glu Ser Gln Ile Met Ser Glu Leu Pro Phe
     690                 695                 700                
 Thr Ile Ala Ser Lys Arg Ile Lys Tyr Leu Gly Ile Gln Leu Thr Lys
 705                 710                 715                 720
 Asp Val Lys Asp Leu Phe Lys Glu Asn Tyr Lys Thr Leu Leu Asn Glu
                 725                 730                 735    
 Ile Lys Glu Asp Thr Asn Lys Trp Lys Asn Ile Pro Cys Ser Trp Ile
             740                 745                 750        
 Gly Arg Ile Asn Ile Val Lys Met Ala Ile Leu Pro Lys Asp Lys Pro
         755                 760                 765            
 Pro His Thr Leu Lys Val Pro Val Lys Thr Pro Leu Ser Ser Thr His
     770                 775                 780                
 Ile Tyr Trp Gly Leu Tyr Gly Val Gly Val Cys Gln Leu Val Ser Gly
 785                 790                 795                 800
 Glu Glu Ile Val Val Ile Ser His Leu Ser Ser Met Thr Leu Thr Ser
                 805                 810                 815    
 Lys Ser Glu Ser Gly Gly Asp Met Pro Ile Asp Glu Glu Val Pro Glu
             820                 825                 830        
 Pro Arg Tyr Thr His Pro Gly Lys Glu Thr Phe Cys Lys Leu Lys Lys
         835                 840                 845            
 Lys Asn Ile Glu Asn Leu Val Asn Arg Thr Ile Asp Gly Thr Trp Leu
     850                 855                 860                
 Cys Val Lys Gln Lys Pro Val Ser Ala Val Lys Ser Pro Asp Leu Glu
 865                 870                 875                 880
 Lys Leu Val Lys Met Asp Asp Ala Trp Ala Ala Gly Trp Arg Ala Ser
                 885                 890                 895    
 Gly Lys
        



      <210> 1556
      <211> 521
      <212> PRT
      <213> Homo sapiens


      <400> 1556
 Met Ile Phe Glu Met Ala Ala Gly Glu Gly Leu Gln Glu Asn Ala Val
   1               5                  10                  15    
 Thr Leu Pro Arg Ala Val Ala His Val Leu Ala Leu Ile Ala Phe Leu
              20                  25                  30        
 Leu Asp Ser Ala Ala Leu Asp Leu Ala Asp Phe Ser Glu Ser Ser Asp
          35                  40                  45            
 Ser Glu Ser Gln Tyr Gly Ala Ser Gly Ala Leu Ser Trp Thr Cys Leu
      50                  55                  60                
 Ser Gln Ala Asp Leu Thr Gly Ile Lys Trp Lys Lys Tyr Val Trp Gln
  65                  70                  75                  80
 Gly Pro Thr Ser Ala Pro Ile Leu Phe Pro Val Thr Glu Glu Asp Pro
                  85                  90                  95    
 Ile Leu Ser Ser Phe Ser Arg Cys Leu Lys Ala Asp Val Leu Gly Val
             100                 105                 110        
 Trp Arg Arg Asp Gln Arg Pro Gly Arg Arg Glu Leu Trp Ile Phe Trp
         115                 120                 125            
 Trp Gly Glu Asp Pro Ser Phe Ala Asp Leu Ile His His Asp Leu Ser
     130                 135                 140                
 Glu Glu Glu Asp Gly Val Trp Glu Asn Gly Leu Ser Tyr Glu Cys Arg
 145                 150                 155                 160
 Thr Leu Leu Phe Lys Ala Val His Asn Leu Leu Glu Arg Cys Leu Met
                 165                 170                 175    
 Asn Arg Asn Phe Val Arg Ile Gly Lys Trp Phe Val Lys Pro Tyr Glu
             180                 185                 190        
 Lys Asp Glu Lys Pro Ile Asn Lys Arg Asn Phe Leu Thr Leu Phe Pro
         195                 200                 205            
 Ser Leu Glu Lys Gln Glu Ile Val Lys Thr Ile Ile Leu Lys Asn Asn
     210                 215                 220                
 Asn Lys Lys Gln His Phe Ala Glu His Leu Lys Cys Glu His Leu Ser
 225                 230                 235                 240
 Cys Ser Phe Thr Phe Phe Leu His Gly Asp Ser Asn Val Cys Thr Ser
                 245                 250                 255    
 Val Glu Ile Asn Gln His Gln Pro Val Tyr Leu Leu Ser Glu Glu His
             260                 265                 270        
 Ile Thr Leu Ala Gln Gln Ser Asn Ser Pro Phe Gln Gly Gln Ala Phe
         275                 280                 285            
 Lys Met Ser Asp Ser Ala Thr Lys Lys Leu Ile Gly Glu Trp Lys Gln
     290                 295                 300                
 Phe Tyr Pro Ile Ser Cys Cys Leu Lys Glu Met Ser Glu Glu Lys Gln
 305                 310                 315                 320
 Glu Asp Met Asp Trp Glu Asp Asp Ser Leu Ala Ala Val Glu Val Leu
                 325                 330                 335    
 Val Ala Gly Val Arg Met Ile Tyr Pro Ala Cys Phe Val Leu Val Pro
             340                 345                 350        
 Gln Ser Asp Ile Pro Thr Pro Ser Pro Val Gly Ser Thr His Cys Ser
         355                 360                 365            
 Ser Ser Cys Leu Gly Val His Gln Val Pro Ala Ser Thr Arg Asp Pro
     370                 375                 380                
 Ala Met Ser Ser Val Thr Leu Thr Pro Pro Thr Ser Pro Glu Glu Val
 385                 390                 395                 400
 Gln Thr Gly Ile Ala Val Ile Cys Leu Ile Ser Ser Val Asp Pro Gln
                 405                 410                 415    
 Ser Val Gln Lys Trp Val Lys Phe Ser Ser Val Ser Asp Gly Phe Asn
             420                 425                 430        
 Ser Asp Ser Thr Ser His His Gly Gly Lys Ile Pro Arg Lys Leu Ala
         435                 440                 445            
 Asn His Val Val Asp Arg Val Trp Gln Glu Cys Asn Met Asn Arg Ala
     450                 455                 460                
 Gln Asn Lys Ile Ala Leu Ala Ile Trp Ala Leu Phe Glu Phe His Arg
 465                 470                 475                 480
 Asn Leu Lys Ile Val Phe Pro Ser Ser Val Lys Asn Val Ile Gly Ser
                 485                 490                 495    
 Leu Ile Arg Ile Ala Leu Asn Pro Asn Cys Phe Gly Gln Tyr Gly His
             500                 505                 510        
 Phe Lys Asp Ile Asp Ser Ser Tyr Pro
         515                 520    



      <210> 1557
      <211> 1128
      <212> PRT
      <213> Homo sapiens


      <400> 1557
 Met Arg Met Gln Ser Ser Ala Lys Leu Leu Cys Ser Ala Trp Thr Leu
   1               5                  10                  15    
 Ala Tyr Ser Ile Ala Val Arg Thr Leu Ser Ser Asp Ser Glu Gly Gln
              20                  25                  30        
 Pro Pro Leu Val Ile His Arg Gln Thr Gly Ser Gly Glu Asp Leu Gln
          35                  40                  45            
 Gln Thr Pro Thr Asp Leu Gln Leu Arg Val Leu Thr Ile Arg Arg Lys
      50                  55                  60                
 Thr Asn Lys Gln Lys Gly His Pro His Gln Asn Pro Ile Ser Ser Arg
  65                  70                  75                  80
 Arg Gln Glu Ile Thr Lys Ile Arg Ala Glu Leu Lys Lys Ile Glu Thr
                  85                  90                  95    
 Gln Lys Pro Phe Lys Lys Ile Asn Glu Ser Arg Ser Trp Phe Phe Glu
             100                 105                 110        
 Lys Ile Asn Lys Ile Asp Arg Leu Leu Ala Arg Leu Ile Lys Lys Lys
         115                 120                 125            
 Ile Glu Lys Asn Gln Ile Asp Ala Ile Lys Asn Asp Lys Gly Asn Ile
     130                 135                 140                
 Thr Thr Asn Pro Thr Glu Ile Gln Thr Thr Ile Arg Glu Tyr Tyr Lys
 145                 150                 155                 160
 His Leu Tyr Ala Asn Lys Leu Glu His Leu Glu Glu Met Asp Lys Phe
                 165                 170                 175    
 Leu Asp Ile Tyr Thr Leu Pro Arg Leu Asn Gln Glu Glu Val Glu Ser
             180                 185                 190        
 Val Asn Arg Pro Ile Thr Gly Ser Glu Ile Glu Ala Ile Ile Asn Ser
         195                 200                 205            
 Leu Pro Thr Lys Lys Ser Pro Gly Pro Asp Arg Phe Thr Ala Glu Leu
     210                 215                 220                
 Tyr Gln Arg Tyr Lys Glu Glu Leu Val Pro Phe Leu Leu Lys Leu Phe
 225                 230                 235                 240
 Gln Ser Ile Glu Lys Glu Gly Ile Leu Pro Asn Ser Phe Tyr Glu Ala
                 245                 250                 255    
 Ser Ile Ile Leu Ile Ser Lys Pro Gly Arg Asp Thr Thr Lys Lys Glu
             260                 265                 270        
 Asn Phe Arg Pro Ile Ser Leu Met Asn Ile Asp Ala Lys Ile Leu Asn
         275                 280                 285            
 Lys Ile Leu Ala Asn Gln Ile Gln Gln His Ile Lys Lys Leu Ile His
     290                 295                 300                
 His His Gln Val Gly Phe Ile Pro Gly Met Gln Gly Trp Phe Asn Ile
 305                 310                 315                 320
 Leu Lys Ser Ile Asn Val Ile His His Ile Asn Arg Thr Lys Asp Lys
                 325                 330                 335    
 Asn His Met Ile Ile Ser Ile Glu Ala Glu Lys Ala Phe Asp Lys Ile
             340                 345                 350        
 Gln Gln Pro Phe Met Leu Lys Thr Leu Asn Lys Leu Gly Ile Asp Gly
         355                 360                 365            
 Thr Tyr Leu Thr Tyr Leu Lys Ile Ile Arg Ala Ile Tyr Asp Lys Pro
     370                 375                 380                
 Thr Ala Asn Ile Ile Leu Asn Gly Gln Lys Leu Glu Ala Phe Pro Phe
 385                 390                 395                 400
 Lys Thr Gly Thr Arg Gln Gly Cys Pro Leu Ser Pro Leu Leu Phe Asn
                 405                 410                 415    
 Ile Val Leu Glu Ala Leu Ala Arg Ala Ile Arg Gln Glu Lys Glu Ile
             420                 425                 430        
 Lys Gly Ile Gln Leu Gly Lys Glu Asp Val Lys Leu Ser Leu Phe Ala
         435                 440                 445            
 Asp Asp Met Ile Val Tyr Leu Glu Asn Pro Ile Val Ser Ala Gln Asn
     450                 455                 460                
 Leu Leu Lys Leu Ile Ser Asn Phe Ser Glu Val Ser Gly Tyr Lys Ile
 465                 470                 475                 480
 Asn Val Gln Lys Ser Gln Ala Phe Leu Tyr Thr Asn Asn Arg Gln Thr
                 485                 490                 495    
 Glu Ser Gln Ile Met Ser Glu Leu Pro Phe Thr Ile Ala Ser Lys Arg
             500                 505                 510        
 Ile Lys Tyr Leu Gly Ile Gln Leu Thr Arg Asp Val Lys Asp Leu Phe
         515                 520                 525            
 Lys Glu Asn Tyr Lys Pro Leu Leu Asn Glu Ile Lys Glu Asp Thr Asn
     530                 535                 540                
 Lys Trp Lys Asn Ile Pro Cys Ser Trp Ile Gly Arg Ile Asn Ile Val
 545                 550                 555                 560
 Lys Met Ala Ile Leu Pro Lys Thr Leu Asn Gln Lys Phe Ser Tyr Trp
                 565                 570                 575    
 Phe Arg Val Asn Lys His Tyr Ile His Gln Arg Thr Phe Pro Leu Lys
             580                 585                 590        
 Glu Thr Glu Phe Asn Thr Ile Ala Thr Leu Tyr Asn Gly Ala Ser Pro
         595                 600                 605            
 Ala Gln His Gln Lys Ala Leu Glu Pro Met Ala Ile Lys His Gln Asp
     610                 615                 620                
 Cys His Gly Ser Glu Glu Leu Pro Phe Ala Val Leu Leu Ser Ser Leu
 625                 630                 635                 640
 Asn Glu Asn Ser Ile Arg Val Ile Cys Leu Val Arg Gln Ile Gly Gly
                 645                 650                 655    
 Lys Arg Glu Phe Leu Gly Val Gln Val Val Leu Lys Thr Lys Pro Glu
             660                 665                 670        
 Leu Ala Phe Pro Val Glu Gly Gly Leu Gln Gly Gln Arg Trp Ile Ser
         675                 680                 685            
 Asn Tyr Leu Tyr Glu Gly Asn Gly Gln Gly Asp Glu Lys Glu Lys Ser
     690                 695                 700                
 Asn Thr Glu Asp Arg Lys Ser Leu Ser Met Glu Met Met Phe Gln Pro
 705                 710                 715                 720
 Arg Gln Glu Gly Val Glu Arg Ala Ser Glu Ala Lys Gly Arg Met Gly
                 725                 730                 735    
 Val Gly Lys Asp Thr Glu Lys Gln Leu Leu Glu Glu Glu Ser Ala Arg
             740                 745                 750        
 Ala Gln Ala Trp Arg Arg Lys Cys Ala Gly Cys Met Val Thr Glu Ser
         755                 760                 765            
 Arg Met Leu Phe Trp Leu Ser Gly Asp Lys Gly Pro Gln Phe Val Thr
     770                 775                 780                
 Met Gly Pro Ala Glu Gly Pro Ala Arg Ser Lys Asn Gln His Lys Lys
 785                 790                 795                 800
 Ile Glu Ser Phe Lys His Leu Ser Leu Asp Asn Ser Ser Gln Glu Glu
                 805                 810                 815    
 Thr Pro Gly Pro Gly Gln Cys His Tyr His Leu Gln Gln Leu Pro Ser
             820                 825                 830        
 Ala Pro His Lys Glu Ala Lys Ala Thr Gln His Lys Arg Val Cys Pro
         835                 840                 845            
 Ser Ile Ser Ser Gln Ser Leu Thr Pro Ser Ser Leu Leu Ser Lys Asp
     850                 855                 860                
 Ile Thr Thr Ala Pro Cys Lys Leu Asn Leu Thr Lys Asp Leu Cys Leu
 865                 870                 875                 880
 Met Asn Glu Gln Pro Tyr Arg Asn Val Ile Gly His Lys Gly Ser Gly
                 885                 890                 895    
 Leu Thr Val Lys Asp Gly Val Gly Lys Pro Ser Lys Thr Thr Glu Phe
             900                 905                 910        
 Phe Thr Glu Tyr Phe Ser Tyr Lys Lys Ser Tyr Pro Lys Lys Pro Tyr
         915                 920                 925            
 Lys Cys Ile Gln Arg Gln Leu Leu Leu Ile Gln Ser Gln Glu Glu Leu
     930                 935                 940                
 Ala Gly Asn His Val Gln Arg Pro Leu Ala Leu Glu Phe Gly Ala Leu
 945                 950                 955                 960
 Phe Ser Pro Gly Gly Ala Ser Trp Gly Phe Gly Asp Leu Lys Ser Tyr
                 965                 970                 975    
 Leu Gly Leu Gln Asn Thr Val Ser Thr His Leu Asp Lys Leu Pro Leu
             980                 985                 990        
 Leu Gly Glu Arg His Met Ser His Gln Thr Pro Met Ser His Pro Trp
         995                1000                1005            
 Pro Leu Ser Gly Thr Leu Pro Leu Thr Ser His Lys Ser Pro Arg Thr
    1010                1015                1020                
 Val His Pro Pro Ala Glu His His Gln Ser Pro Leu Pro Ile Pro Leu
1025                1030                1035                1040
 Pro Val Thr Ala Lys Gly Ala Phe Ala Ser Val Pro Pro Leu Leu Phe
                1045                1050                1055    
 Pro Ala Pro Gln Gly Leu Ser Asn Glu Gly Arg Arg Cys His Gly Tyr
            1060                1065                1070        
 Ile Leu Ile Asn Ile Ser Gly Ile Thr Asn Asn Thr Glu Ile Tyr Ala
        1075                1080                1085            
 Ser Leu Val Thr Ile Thr Leu Gln His Phe Leu Leu Pro Ser Glu Asp
    1090                1095                1100                
 Cys Gly Lys Ala Pro Leu Gln Gly Arg Val Glu Gly Arg Glu Gly Val
1105                1110                1115                1120
 Ser Gln Lys Glu Lys Arg Lys Thr
                1125            



      <210> 1558
      <211> 1736
      <212> PRT
      <213> Homo sapiens


      <400> 1558
 Met Trp Ala Leu Trp Lys Val Thr Lys His Leu Leu Ala Leu Ser Pro
   1               5                  10                  15    
 Thr Leu Trp Ala Gly Ala Tyr Arg Glu Val His Thr Ala Thr Ser Ala
              20                  25                  30        
 Leu Gln Gln Ile Gly Arg Thr Asp Ala Pro Gly His Arg Glu Pro Trp
          35                  40                  45            
 Arg Arg Gly Glu Cys Val Arg Gln Cys Gly Leu His Cys Lys Glu Glu
      50                  55                  60                
 Glu Glu Phe Cys Glu Leu Leu Tyr Arg Tyr Ser Gln Met Gln Thr Lys
  65                  70                  75                  80
 Ser Gly Ser Gln Val Gln Met His Leu Leu Gly Phe Asn Met Gly Ile
                  85                  90                  95    
 Gly Asn Gln Leu Pro Gly Gly Val Lys Asn Lys Ala Arg Arg Pro Glu
             100                 105                 110        
 Val Ser Gln Asp Lys Met Gly Phe Leu Phe Arg Leu Ser Ser Leu Ser
         115                 120                 125            
 Ser Leu Gly Asp Ser Ala Pro Glu Arg Lys Ser Pro Ser His His Arg
     130                 135                 140                
 Gln Pro Ser Asp Ala Ser Glu Thr Thr Gly Leu Val Gln Arg Cys Val
 145                 150                 155                 160
 Ile Ile Gln Lys Asp Gln His Gly Phe Gly Phe Thr Val Ser Gly Asp
                 165                 170                 175    
 Arg Ile Val Leu Val Gln Ser Val Arg Pro Gly Gly Ala Ala Met Lys
             180                 185                 190        
 Ala Gly Val Lys Glu Gly Asp Arg Ile Ile Lys Val Asn Gly Thr Met
         195                 200                 205            
 Val Thr Asn Ser Ser His Leu Glu Val Val Lys Leu Ile Lys Ser Gly
     210                 215                 220                
 Ala Tyr Val Ala Leu Thr Leu Leu Gly Ser Ser Pro Ser Ser Met Gly
 225                 230                 235                 240
 Ile Ser Gly Leu Gln Gln Asp Pro Ser Pro Ala Gly Ala Pro Arg Ile
                 245                 250                 255    
 Thr Ser Val Ile Pro Ser Pro Pro Pro Pro Pro Pro Leu Pro Pro Pro
             260                 265                 270        
 Gln Arg Ile Thr Gly Pro Lys Pro Leu Gln Asp Pro Glu Val Gln Lys
         275                 280                 285            
 His Ala Thr Gln Ile Leu Arg Asn Met Leu Arg Gln Glu Glu Lys Glu
     290                 295                 300                
 Leu Gln Arg Ile Cys Glu Val Tyr Ser Arg Asn Pro Ala Ser Leu Leu
 305                 310                 315                 320
 Glu Glu Gln Ile Glu Gly Ala Arg Arg Arg Val Thr Gln Leu Gln Leu
                 325                 330                 335    
 Lys Ile Gln Gln Glu Thr Gly Gly Ser Val Asp Ile Leu Pro Leu Tyr
             340                 345                 350        
 Gly Asp Thr Ser Gln Arg Pro Ser Glu Gly Arg Leu Ser Leu Asp Ser
         355                 360                 365            
 Gln Glu Gly Asp Ser Gly Leu Asp Ser Gly Thr Glu Arg Phe Pro Ser
     370                 375                 380                
 Leu Ser Glu Ser Leu Met Asn Arg Asn Ser Val Leu Ser Asp Pro Gly
 385                 390                 395                 400
 Leu Asp Ser Pro Arg Thr Ser Pro Val Ile Met Ala Arg Val Ala Gln
                 405                 410                 415    
 His His Arg Arg Gln Gly Ser Asp Ala Ala Val Pro Ser Thr Gly Asp
             420                 425                 430        
 Gln Gly Val Asp Gln Ser Pro Lys Pro Leu Ile Ile Gly Pro Glu Glu
         435                 440                 445            
 Asp Tyr Asp Pro Gly Tyr Phe Asn Asn Glu Ser Asp Ile Ile Phe Gln
     450                 455                 460                
 Asp Leu Glu Lys Leu Lys Ser Arg Pro Ala His Leu Gly Val Phe Leu
 465                 470                 475                 480
 Arg Tyr Ile Phe Ser Gln Ala Asp Pro Ser Pro Leu Leu Phe Tyr Leu
                 485                 490                 495    
 Cys Ala Glu Val Tyr Gln Gln Ala Ser Pro Lys Asp Ser Arg Ser Leu
             500                 505                 510        
 Gly Lys Asp Ile Trp Asn Ile Phe Leu Glu Lys Asn Ala Pro Leu Arg
         515                 520                 525            
 Val Lys Ile Pro Glu Met Leu Gln Ala Glu Ile Asp Ser Arg Leu Arg
     530                 535                 540                
 Asn Ser Glu Asp Ala Arg Gly Val Leu Cys Glu Ala Gln Glu Ala Ala
 545                 550                 555                 560
 Met Pro Glu Ile Gln Glu Gln Ile His Asp Tyr Arg Thr Lys Arg Thr
                 565                 570                 575    
 Leu Gly Leu Gly Ser Leu Tyr Gly Glu Asn Asp Leu Leu Asp Leu Asp
             580                 585                 590        
 Gly Asp Pro Leu Arg Glu Arg Gln Val Ala Glu Lys Gln Leu Ala Ala
         595                 600                 605            
 Leu Gly Asp Ile Leu Ser Lys Tyr Glu Glu Asp Arg Ser Ala Pro Met
     610                 615                 620                
 Asp Phe Ala Leu Asn Thr Tyr Met Ser His Ala Gly Ile Arg Leu Arg
 625                 630                 635                 640
 Glu Ala Arg Pro Ser Asn Thr Ala Glu Lys Ala Gln Ser Ala Pro Asp
                 645                 650                 655    
 Lys Asp Lys Trp Leu Pro Phe Phe Pro Lys Thr Lys Lys Ser Ser Asn
             660                 665                 670        
 Ser Lys Lys Glu Lys Asp Ala Leu Glu Asp Lys Lys Arg Asn Pro Ile
         675                 680                 685            
 Leu Lys Tyr Ile Gly Lys Pro Lys Ser Ser Ser Gln Ser Ile Cys Trp
     690                 695                 700                
 Gln Arg Ala Phe Leu Cys Phe Trp Glu Pro Gln Ala Gln Thr Gln Thr
 705                 710                 715                 720
 Thr Ala Thr Phe Ser Pro Cys Gln Ile Gln Cys Arg Ile Ser Glu Val
                 725                 730                 735    
 Gln Val Asn Val Ser Glu Pro Gly Lys Pro Cys Arg Ser Leu Gly Leu
             740                 745                 750        
 Ser Leu Gly Thr Gln Ser Ser Ser Ser Tyr Gln Thr Thr Thr Lys Asn
         755                 760                 765            
 Leu Ile Met Thr Phe Lys Gln Lys Arg Tyr Tyr Asn Asn Val Arg Ala
     770                 775                 780                
 Lys Arg Met Leu Met Glu Asn Ile Leu Pro Asn Pro Leu Ile Leu Arg
 785                 790                 795                 800
 Met Arg Lys Glu Ser Thr Gln Lys Val Lys Pro Gly Asn Val Arg Asn
                 805                 810                 815    
 Ile Ile Gln His Phe Glu Asn Asn Gln Gln Tyr Asp Ala Pro Glu Pro
             820                 825                 830        
 Gly Thr Gln Arg Leu Ser Thr Gly Ser Phe Pro Glu Asp Leu Leu Glu
         835                 840                 845            
 Ser Asp Ser Ser Arg Ser Glu Ile Arg Leu Gly Arg Ser Glu Ser Leu
     850                 855                 860                
 Lys Gly Arg Glu Glu Met Lys Arg Ser Arg Lys Ala Glu Asn Val Pro
 865                 870                 875                 880
 Arg Ser Arg Ser Asp Val Asp Met Asp Ala Ala Ala Glu Ala Thr Arg
                 885                 890                 895    
 Leu His Gln Ser Ala Ser Ser Ser Thr Ser Ser Leu Ser Thr Arg Ser
             900                 905                 910        
 Ile Glu Ser Pro Ser Leu Gly Phe Cys Thr Asp Thr Leu Leu Pro His
         915                 920                 925            
 Leu Leu Glu Asp Asp Leu Gly Gln Leu Ser Asp Leu Glu Pro Glu Pro
     930                 935                 940                
 Asp Ala Gln Asn Trp Gln His Thr Val Gly Lys Asp Val Val Ala Gly
 945                 950                 955                 960
 Leu Thr Gln Arg Glu Ile Asp Arg Gln Glu Val Ile Asn Glu Leu Phe
                 965                 970                 975    
 Val Thr Glu Ala Ser His Leu Arg Thr Leu Arg Val Leu Asp Leu Ile
             980                 985                 990        
 Phe Tyr Gln Arg Met Lys Lys Glu Asn Leu Met Pro Arg Glu Glu Leu
         995                1000                1005            
 Ala Arg Leu Phe Pro Asn Leu Pro Glu Leu Ile Glu Ile His Asn Ser
    1010                1015                1020                
 Trp Cys Glu Ala Met Lys Lys Leu Arg Glu Glu Gly Pro Ile Ile Lys
1025                1030                1035                1040
 Glu Ile Ser Asp Leu Met Leu Ala Arg Phe Asp Gly Pro Ala Arg Glu
                1045                1050                1055    
 Glu Leu Gln Gln Val Ala Ala Gln Phe Cys Ser Tyr Gln Ser Ile Ala
            1060                1065                1070        
 Leu Glu Leu Ile Lys Thr Lys Gln Arg Lys Glu Ser Arg Phe Gln Leu
        1075                1080                1085            
 Phe Met Gln Glu Ala Glu Ser His Pro Gln Cys Arg Arg Leu Gln Leu
    1090                1095                1100                
 Arg Asp Leu Ile Ile Ser Glu Met Gln Arg Leu Thr Lys Tyr Pro Leu
1105                1110                1115                1120
 Leu Leu Glu Ser Ile Ile Lys His Thr Glu Gly Gly Thr Ser Glu His
                1125                1130                1135    
 Glu Lys Leu Cys Arg Ala Arg Asp Gln Cys Arg Glu Ile Leu Lys Tyr
            1140                1145                1150        
 Val Asn Glu Ala Val Lys Gln Thr Glu Asn Arg His Arg Leu Glu Gly
        1155                1160                1165            
 Tyr Gln Lys Arg Leu Asp Ala Thr Ala Leu Glu Arg Ala Ser Asn Pro
    1170                1175                1180                
 Leu Ala Ala Glu Phe Lys Ser Leu Asp Leu Thr Thr Arg Lys Met Ile
1185                1190                1195                1200
 His Glu Gly Pro Leu Thr Trp Arg Ile Ser Lys Asp Lys Thr Leu Asp
                1205                1210                1215    
 Leu His Val Leu Leu Leu Glu Asp Leu Leu Val Leu Leu Gln Lys Gln
            1220                1225                1230        
 Asp Glu Lys Leu Leu Leu Lys Cys His Ser Lys Thr Ala Val Gly Ser
        1235                1240                1245            
 Ser Asp Ser Lys Gln Thr Phe Ser Pro Val Leu Lys Leu Asn Ala Val
    1250                1255                1260                
 Leu Ile Arg Ser Val Ala Thr Asp Lys Arg Ala Phe Phe Ile Ile Cys
1265                1270                1275                1280
 Thr Ser Lys Leu Gly Pro Pro Gln Ile Tyr Glu Leu Val Ala Leu Thr
                1285                1290                1295    
 Ser Ser Asp Lys Asn Thr Trp Met Glu Leu Leu Glu Glu Ala Val Arg
            1300                1305                1310        
 Asn Ala Thr Arg His Pro Gly Ala Ala Pro Met Pro Val His Pro Pro
        1315                1320                1325            
 Pro Pro Gly Pro Arg Glu Pro Ala Gln Gln Gly Pro Thr Pro Ser Ser
    1330                1335                1340                
 Leu Pro Pro Gly Tyr Asn Arg Ala Glu Pro Glu Glu Gly Val Glu Leu
1345                1350                1355                1360
 Asp Asp Ser Asp Val Phe His Gly Glu Pro Glu Pro Glu Glu Leu Pro
                1365                1370                1375    
 Gly Gly Thr Gly Ser Gln Gln Arg Val Gln Gly Lys His Gln Val Leu
            1380                1385                1390        
 Leu Glu Asp Pro Glu Gln Glu Gly Ser Ala Glu Glu Glu Glu Leu Gly
        1395                1400                1405            
 Val Leu Pro Cys Pro Ser Thr Ser Leu Asp Gly Glu Asn Arg Gly Ile
    1410                1415                1420                
 Arg Thr Arg Asn Pro Ile His Leu Ala Phe Pro Gly Pro Leu Phe Met
1425                1430                1435                1440
 Glu Gly Leu Ala Asp Ser Ala Leu Glu Asp Val Glu Asn Leu Arg His
                1445                1450                1455    
 Leu Ile Leu Trp Ser Leu Leu Pro Gly His Thr Met Glu Thr Gln Ala
            1460                1465                1470        
 Ala Gln Glu Pro Glu Asp Asp Leu Thr Pro Thr Pro Ser Val Ile Ser
        1475                1480                1485            
 Val Thr Ser His Pro Trp Asp Pro Gly Ser Pro Gly Gln Ala Pro Pro
    1490                1495                1500                
 Gly Gly Glu Gly Asp Asn Thr Gln Leu Ala Gly Leu Glu Gly Glu Arg
1505                1510                1515                1520
 Pro Glu Gln Glu Asp Met Gly Leu Cys Ser Leu Glu His Leu Pro Pro
                1525                1530                1535    
 Arg Thr Arg Asn Ser Gly Ile Trp Glu Ser Pro Glu Leu Asp Arg Asn
            1540                1545                1550        
 Leu Ala Glu Asp Ala Ser Ser Thr Glu Ala Ala Gly Gly Tyr Lys Val
        1555                1560                1565            
 Val Arg Lys Gly Asn Cys Phe Tyr Val Ser Met Pro Ser Gly Pro Pro
    1570                1575                1580                
 Asp Ser Ser Thr Asp His Ser Glu Ala Pro Met Ser Pro Pro Gln Pro
1585                1590                1595                1600
 Asp Ser Leu Pro Ala Gly Gln Thr Glu Pro Gln Pro Gln Leu Gln Gly
                1605                1610                1615    
 Gly Asn Asp Asp Pro Arg Arg Pro Ser Arg Ser Pro Pro Ser Leu Ala
            1620                1625                1630        
 Leu Arg Asp Val Gly Met Ile Phe His Thr Ile Glu Gln Leu Thr Leu
        1635                1640                1645            
 Lys Leu Asn Arg Leu Lys Asp Met Glu Leu Ala His Arg Glu Leu Leu
    1650                1655                1660                
 Lys Ser Leu Gly Gly Glu Ser Ser Gly Gly Thr Thr Pro Val Gly Ser
1665                1670                1675                1680
 Phe His Thr Glu Ala Ala Arg Trp Thr Asp Gly Ser Leu Ser Pro Pro
                1685                1690                1695    
 Ala Lys Glu Pro Leu Ala Ser Asp Ser Arg Asn Ser His Glu Leu Gly
            1700                1705                1710        
 Pro Cys Pro Glu Asp Gly Ser Asp Ala Pro Leu Glu Asp Ser Thr Ala
        1715                1720                1725            
 Asp Ala Ala Ala Ser Pro Gly Pro
    1730                1735    



      <210> 1559
      <211> 465
      <212> PRT
      <213> Homo sapiens


      <400> 1559
 Met Leu His Ile Val Met Phe Ser Leu Ser Ile Leu Ser Gln Lys Glu
   1               5                  10                  15    
 Lys Glu Ala Gly Gly Phe Pro Leu Lys Gly Leu Asp Arg Gln Leu Glu
              20                  25                  30        
 Ser Ala Arg Gly Pro Asn Ala Leu Gln Ser Ala Tyr Asp Glu Cys Cys
          35                  40                  45            
 Gln Ala Trp Asp Ser Pro Phe Arg Val Val Gly Phe Pro Asn Pro Trp
      50                  55                  60                
 Pro Arg Thr Gly Pro Glu Met Pro Ser Lys Ser Gln Gly Leu Glu Leu
  65                  70                  75                  80
 Arg Thr Leu Arg Ala His Leu Val Leu Tyr Pro Thr Val Ala Glu Leu
                  85                  90                  95    
 Leu Pro Lys Leu Gln Asp Lys Val Ser Phe Thr Leu Phe Ser Pro Phe
             100                 105                 110        
 Leu Lys Gln Glu Ser Leu Pro Ile Ala Thr Thr Val Arg Lys His Leu
         115                 120                 125            
 Tyr Gly Leu Phe His Tyr Asn Pro Met Met Leu Gly Leu Glu Ser Leu
     130                 135                 140                
 Pro Asp Pro Thr Asp Thr Trp Glu Ile Ile Glu Thr Ile Gly Lys Gly
 145                 150                 155                 160
 Thr Tyr Gly Lys Val Tyr Lys Val Thr Asn Lys Arg Asp Gly Ser Leu
                 165                 170                 175    
 Ala Ala Val Lys Ile Leu Asp Pro Val Ser Asp Met Asp Glu Glu Ile
             180                 185                 190        
 Glu Ala Glu Tyr Asn Ile Leu Gln Phe Leu Pro Asn His Pro Asn Val
         195                 200                 205            
 Val Lys Phe Tyr Gly Met Phe Tyr Lys Ala Asp His Cys Val Gly Gly
     210                 215                 220                
 Gln Leu Trp Leu Val Leu Glu Gly Lys Thr Val Arg Ser Pro Ser Glu
 225                 230                 235                 240
 Ala Tyr Leu Arg Val Ala Gly Gln Arg Gly His His Pro Arg Leu Gln
                 245                 250                 255    
 Leu His Asp His Leu Glu Phe Asp Val Met Lys Leu Cys Asn Gly Gly
             260                 265                 270        
 Ser Val Thr Glu Leu Val Lys Gly Leu Leu Arg Cys Gly Gln Arg Leu
         275                 280                 285            
 Asp Glu Ala Met Ile Ser Tyr Ile Leu Tyr Gly Ala Leu Leu Val Arg
     290                 295                 300                
 Thr Ser Ile Lys Trp Gly Val Ser Ala Gln Leu Thr Ser Thr Arg Leu
 305                 310                 315                 320
 Arg Arg Asn Thr Ser Val Gly Thr Pro Phe Trp Met Ala Pro Glu Gly
                 325                 330                 335    
 Ser Tyr Asp Asn Ser Ala Cys Glu Tyr Leu Arg Gly Ser Ser Gly Ser
             340                 345                 350        
 Asn Met Pro Ile Ala Thr Gly Glu Gly Thr His Gly Ala Thr Lys Gln
         355                 360                 365            
 Arg Glu Val Lys Val Ile Ala Cys Glu Gln Gln Tyr Asp Ser Ser Tyr
     370                 375                 380                
 Asp Ala Arg Cys Asp Val Trp Ser Leu Gly Ile Thr Ala Ile Glu Leu
 385                 390                 395                 400
 Gly Asp Gly Asp Pro Pro Leu Phe Asp Met His Pro Val Lys Thr Leu
                 405                 410                 415    
 Phe Lys Ile Pro Arg Cys Glu Gln Pro Pro Thr Thr Ile Pro Lys Met
             420                 425                 430        
 Ile Pro Thr Gln Ala Arg Val Ser Leu Phe Ala Phe Phe Glu Ser Gln
         435                 440                 445            
 Lys Gln Val Thr Ala Ile Arg Gly Ala Asp Glu Ala Pro Gly Phe Leu
     450                 455                 460                
 Asn
 465



      <210> 1560
      <211> 1068
      <212> PRT
      <213> Homo sapiens


      <400> 1560
 Met Gly Met Glu Ala Arg Cys Arg Val Ala Leu Pro Leu Val Ser Pro
   1               5                  10                  15    
 Ser Val Leu Gln Ala Phe His Phe Tyr Tyr Phe Leu Tyr Ser Ser Leu
              20                  25                  30        
 Lys Pro Ser Glu Glu Asp Pro Val Ile Arg Val Ser Arg Met Arg Lys
          35                  40                  45            
 Leu Gly Leu Gln Ser Arg Ala Lys Lys Asp His Asn Glu Asp Leu Gly
      50                  55                  60                
 His Leu Ser Ala Asp Ala Pro Trp Pro Ala Val Thr Met Ala Pro Arg
  65                  70                  75                  80
 Lys Arg Ser His His Gly Leu Gly Phe Leu Cys Cys Phe Gly Gly Ser
                  85                  90                  95    
 Asp Ile Pro Glu Ile Asn Leu Arg Asp Asn His Pro Leu Gln Phe Met
             100                 105                 110        
 Glu Phe Ser Ser Pro Ile Pro Asn Ala Glu Glu Leu Asn Ile Arg Phe
         115                 120                 125            
 Ala Glu Leu Val Asp Glu Leu Asp Leu Thr Asp Lys Asn Arg Glu Ala
     130                 135                 140                
 Met Phe Ala Leu Pro Pro Glu Lys Lys Trp Gln Ile Tyr Cys Ser Lys
 145                 150                 155                 160
 Lys Lys Glu Gln Glu Asp Pro Asn Lys Leu Ala Thr Ser Trp Pro Asp
                 165                 170                 175    
 Tyr Tyr Ile Asp Arg Ile Asn Ser Met Ala Ala Met Gln Ser Leu Tyr
             180                 185                 190        
 Ala Phe Asp Glu Glu Glu Thr Glu Met Arg Asn Gln Val Val Glu Asp
         195                 200                 205            
 Leu Lys Thr Ala Leu Arg Thr Gln Pro Met Arg Phe Val Thr Arg Phe
     210                 215                 220                
 Ile Glu Leu Glu Gly Leu Thr Cys Leu Leu Asn Phe Leu Arg Ser Met
 225                 230                 235                 240
 Asp His Ala Thr Cys Glu Ser Arg Ile His Thr Ser Leu Ile Gly Cys
                 245                 250                 255    
 Ile Lys Ala Leu Met Asn Asn Ser Gln Gly Arg Ala His Val Leu Ala
             260                 265                 270        
 Gln Pro Glu Ala Ile Ser Thr Ile Ala Gln Ser Leu Arg Thr Glu Asn
         275                 280                 285            
 Ser Lys Thr Lys Val Ala Val Leu Glu Ile Leu Gly Ala Val Cys Leu
     290                 295                 300                
 Val Pro Gly Gly His Lys Lys Val Leu Gln Ala Met Leu His Tyr Gln
 305                 310                 315                 320
 Val Tyr Ala Ala Glu Arg Thr Arg Phe Gln Thr Leu Leu Asn Glu Leu
                 325                 330                 335    
 Asp Arg Ser Leu Gly Arg Tyr Arg Asp Glu Val Asn Leu Lys Thr Ala
             340                 345                 350        
 Ile Met Ser Phe Ile Asn Ala Val Leu Asn Ala Gly Ala Gly Glu Asp
         355                 360                 365            
 Asn Leu Glu Phe Arg Leu His Leu Arg Tyr Glu Phe Leu Met Leu Gly
     370                 375                 380                
 Ile Gln Pro Val Ile Asp Lys Leu Arg Gln His Glu Asn Ala Ile Leu
 385                 390                 395                 400
 Asp Lys His Leu Asp Phe Phe Glu Met Val Arg Asn Glu Asp Asp Leu
                 405                 410                 415    
 Glu Leu Ala Arg Arg Phe Asp Met Val His Ile Asp Thr Lys Ser Ala
             420                 425                 430        
 Ser Gln Met Phe Glu Leu Ile His Lys Lys Leu Lys Tyr Thr Glu Ala
         435                 440                 445            
 Tyr Pro Cys Leu Leu Ser Val Leu His His Cys Leu Gln Met Pro Tyr
     450                 455                 460                
 Lys Arg Asn Gly Gly Tyr Phe Gln Gln Trp Gln Leu Leu Asp Arg Ile
 465                 470                 475                 480
 Leu Gln Gln Ile Val Leu Gln Asp Glu Arg Gly Val Asp Pro Asp Leu
                 485                 490                 495    
 Ala Pro Leu Glu Asn Phe Asn Val Lys Asn Ile Val Asn Met Leu Ile
             500                 505                 510        
 Asn Glu Asn Glu Val Lys Gln Trp Arg Asp Gln Ala Glu Lys Phe Arg
         515                 520                 525            
 Lys Glu His Met Glu Leu Val Ser Arg Leu Glu Arg Lys Glu Arg Glu
     530                 535                 540                
 Cys Glu Thr Lys Thr Leu Glu Lys Glu Glu Met Met Arg Thr Leu Asn
 545                 550                 555                 560
 Lys Met Lys Asp Lys Leu Ala Arg Glu Ser Gln Glu Leu Arg Gln Ala
                 565                 570                 575    
 Arg Gly Gln Val Ala Glu Leu Asp Pro Tyr Pro Ser Ser Asp Val Pro
             580                 585                 590        
 Leu Arg Lys Lys Arg Val Pro Gln Pro Ser His Pro Leu Lys Ser Phe
         595                 600                 605            
 Asn Trp Val Lys Leu Asn Glu Glu Arg Val Pro Gly Thr Val Trp Asn
     610                 615                 620                
 Glu Ile Asp Asp Met Gln Val Phe Arg Ile Leu Asp Leu Glu Asp Phe
 625                 630                 635                 640
 Glu Lys Met Phe Ser Ala Tyr Gln Arg His Gln Lys Glu Leu Gly Ser
                 645                 650                 655    
 Thr Glu Asp Ile Tyr Leu Ala Ser Arg Lys Val Lys Glu Leu Ser Val
             660                 665                 670        
 Ile Asp Gly Arg Arg Ala Gln Asn Cys Ile Ile Leu Leu Ser Lys Leu
         675                 680                 685            
 Lys Leu Ser Asn Glu Glu Ile Arg Gln Ala Ile Leu Lys Met Asp Glu
     690                 695                 700                
 Gln Glu Asp Leu Ala Lys Asp Met Leu Glu Gln Leu Leu Lys Phe Ile
 705                 710                 715                 720
 Pro Glu Lys Ser Asp Ile Asp Leu Leu Glu Glu His Lys His Glu Ile
                 725                 730                 735    
 Glu Arg Met Ala Arg Ala Asp Arg Phe Leu Tyr Glu Met Ser Arg Ile
             740                 745                 750        
 Asp His Tyr Gln Gln Arg Leu Gln Ala Leu Phe Phe Lys Lys Lys Phe
         755                 760                 765            
 Gln Glu Arg Leu Ala Glu Ala Lys Pro Lys Val Glu Ala Ile Leu Leu
     770                 775                 780                
 Ala Ser Arg Glu Leu Val Arg Ser Lys Arg Leu Arg Gln Met Leu Glu
 785                 790                 795                 800
 Val Ile Leu Ala Ile Gly Asn Phe Met Asn Lys Gly Gln Arg Gly Gly
                 805                 810                 815    
 Ala Tyr Gly Phe Arg Val Ala Ser Leu Asn Lys Ile Ala Asp Thr Lys
             820                 825                 830        
 Ser Ser Ile Asp Arg Asn Ile Ser Leu Leu His Tyr Leu Ile Met Ile
         835                 840                 845            
 Leu Glu Lys His Phe Pro Asp Ile Leu Asn Met Pro Ser Glu Leu Gln
     850                 855                 860                
 His Leu Pro Glu Ala Ala Lys Val Asn Leu Ala Glu Leu Glu Lys Glu
 865                 870                 875                 880
 Val Gly Asn Leu Arg Arg Gly Leu Arg Ala Val Glu Val Glu Leu Glu
                 885                 890                 895    
 Tyr Gln Arg Arg Gln Val Arg Glu Pro Ser Asp Lys Phe Val Pro Val
             900                 905                 910        
 Met Ser Asp Phe Ile Thr Val Ser Ser Phe Ser Phe Ser Glu Leu Glu
         915                 920                 925            
 Asp Gln Leu Asn Glu Ala Arg Asp Lys Phe Ala Lys Ala Leu Met His
     930                 935                 940                
 Phe Gly Glu His Asp Ser Lys Met Gln Pro Asp Glu Phe Phe Gly Ile
 945                 950                 955                 960
 Phe Asp Thr Phe Leu Gln Ala Phe Ser Glu Ala Arg Gln Asp Leu Glu
                 965                 970                 975    
 Ala Met Arg Arg Arg Lys Glu Glu Glu Glu Arg Arg Ala Arg Met Glu
             980                 985                 990        
 Ala Met Leu Lys Glu Gln Arg Glu Arg Glu Arg Trp Gln Arg Gln Arg
         995                1000                1005            
 Lys Val Leu Ala Ala Gly Ser Ser Leu Glu Glu Gly Gly Glu Phe Asp
    1010                1015                1020                
 Asp Leu Val Ser Ala Leu Arg Ser Gly Glu Val Phe Asp Lys Asp Leu
1025                1030                1035                1040
 Cys Lys Leu Lys Arg Ser Arg Lys Arg Ser Gly Ser Gln Ala Leu Glu
                1045                1050                1055    
 Val Thr Arg Glu Arg Ala Ile Asn Arg Leu Asn Tyr
            1060                1065            



      <210> 1561
      <211> 443
      <212> PRT
      <213> Homo sapiens


      <400> 1561
 Met Pro Ala Val Ala Tyr Ala Leu Gly Ala Lys Trp Leu Leu His Leu
   1               5                  10                  15    
 Thr Thr Met Lys Thr Gly Val Glu Gly Ser Phe Trp Met Tyr Leu Gly
              20                  25                  30        
 Arg Val Pro Asn Ala Gly Ala Met Glu Leu Ser Ala Ala Ala Leu Asp
          35                  40                  45            
 Ser His Arg Ser Met His Pro Ile Val Asn His Ala Cys Glu Gly Ser
      50                  55                  60                
 Thr Leu Arg Cys Pro Tyr Glu Asn Leu Met Pro Asp Ala Leu Ser Leu
  65                  70                  75                  80
 Ser Pro Ile Leu Ser Ser Ser Pro Ala His Arg Ala Leu Arg Asp Leu
                  85                  90                  95    
 Ser Arg Pro Ser Ser Tyr Leu Thr Glu Ala Ser Pro Gly Arg Phe Ser
             100                 105                 110        
 Leu Ser Ser Gly Ser Gly Asp Arg Leu Ser Lys Arg Arg Ser Gly Leu
         115                 120                 125            
 Thr Leu Ala Ser Val Gly His Val Ile Thr His Thr Gly Leu Phe Arg
     130                 135                 140                
 Ile Arg Gly Cys Leu Ser Thr Gly Arg Asp Pro Ala Cys Cys Arg Pro
 145                 150                 155                 160
 Leu Gln Asp Ala Pro Leu Pro Asp Ser Gly Pro Ser Arg Pro Arg Cys
                 165                 170                 175    
 Tyr Val Ile Met Ala Ser Ala Gly Leu Cys Met Lys Ser Gly Ser Arg
             180                 185                 190        
 Ala Leu Cys Ser Gly Gly Arg Ser Leu Thr Arg Pro Lys Ala Val Arg
         195                 200                 205            
 Thr Pro Pro Ser Ser Gln Trp Glu Glu Thr Gly Lys Cys Thr Gly Gly
     210                 215                 220                
 Ala Ala Lys Val Gln Thr Leu His Gln Ala Trp Gln Gly Thr Ala Asn
 225                 230                 235                 240
 Pro Arg Asn Phe Pro Ser Ala Glu Lys Ala Ala Ile Phe Pro Arg Ala
                 245                 250                 255    
 Asn Lys Gln Asn Val Val Thr Glu Ser Glu Glu Ala Gly Phe Gln Pro
             260                 265                 270        
 Trp Gln Thr Asp Ser Arg Ala Val Leu Ser Thr Leu Ala Thr Gln Pro
         275                 280                 285            
 Pro Ala Arg Ala Arg Val Gly Asn Arg Lys Thr Trp Gln Cys Pro Pro
     290                 295                 300                
 Thr Leu Thr Ser Cys Met Glu Glu Ala Pro Gly Ser Ala Thr Pro Leu
 305                 310                 315                 320
 Ala Gln Ser Val Glu Gly Lys Lys Arg Cys Phe Asn Val Leu Glu Val
                 325                 330                 335    
 Asp Leu Glu Lys Gln Ser Arg Arg Glu Phe Lys Ala Thr Gly Pro Val
             340                 345                 350        
 Pro Ile Ile Ala Gly His Val Pro Cys Leu Thr Val Ala Gly Phe Thr
         355                 360                 365            
 Ala Pro Leu Leu Leu His Phe Ile Pro Val Ala Val Phe Thr Asp Leu
     370                 375                 380                
 Ser Leu Gly Ser His Thr Glu Ser Tyr Phe Gly Ser Glu Arg Gln Phe
 385                 390                 395                 400
 Pro Ser Thr Ser Leu Pro Ser Leu Glu Leu Gln Val Ser Val Ile Ser
                 405                 410                 415    
 Ala Tyr Ser Ser Gly Leu Pro Thr Val Ala Val Ser Ser Ser Phe Pro
             420                 425                 430        
 Thr Pro Ile Val Asn Asn Val Ser Ser Ile Gln
         435                 440            



      <210> 1562
      <211> 977
      <212> PRT
      <213> Homo sapiens


      <400> 1562
 Met His Leu Gly Thr Leu Leu Leu Gln Asp Gln Leu Phe Leu Thr Phe
   1               5                  10                  15    
 Gln Leu Phe Leu Thr Val Lys Gly Asp Arg Phe Pro Glu Ser Gly Arg
              20                  25                  30        
 Gln Trp Glu Lys Gln Ser Ser Ser Ser Arg Leu Lys Ser Gly Ile Phe
          35                  40                  45            
 Pro Lys Ser Phe Ile His Ile Lys Glu Val Thr Val Glu Lys Arg Arg
      50                  55                  60                
 Asn Thr Glu Asn Ile Ile Pro Ala Glu Ile Pro Leu Ala Gln Glu Val
  65                  70                  75                  80
 Thr Thr Thr Leu Trp Glu Trp Gly Ser Ile Trp Lys Gln Leu Tyr Val
                  85                  90                  95    
 Ala Ser Lys Lys Glu Arg Phe Leu Gln Val Gln Ser Met Met Tyr Asp
             100                 105                 110        
 Leu Met Glu Trp Arg Ser Gln Leu Leu Ser Gly Thr Leu Pro Lys Asp
         115                 120                 125            
 Glu Leu Lys Glu Leu Lys Gln Lys Val Thr Ser Lys Ile Asp Tyr Gly
     130                 135                 140                
 Asn Lys Ser Leu Phe Ser Phe Leu Asp Ala Ile Leu Ser Leu Ser Val
 145                 150                 155                 160
 Trp Glu Lys Val Val Thr Asn Gly Cys Ala Cys Val Pro Leu Leu Pro
                 165                 170                 175    
 Pro Leu Gly Asp Leu Gly Thr Cys Arg Ile Trp Tyr Leu Val Val Ala
             180                 185                 190        
 Thr Lys Gln Glu Tyr Gly Trp Pro Ser Gln Asn Pro Ser Ala Pro Pro
         195                 200                 205            
 Pro Pro Thr Phe Phe Val Trp Thr Thr Glu Ala Leu His Leu Asn Ile
     210                 215                 220                
 Lys Cys Lys Ser Ser Phe Lys Phe Lys Phe Leu Leu Tyr Arg Ile Leu
 225                 230                 235                 240
 Glu Leu Asp Leu Ile Val Arg Asp Glu Asp Gly Asn Ile Leu Asp Pro
                 245                 250                 255    
 Asp Asn Thr Ser Val Ile Ser Leu Phe His Ala His Glu Glu Ala Thr
             260                 265                 270        
 Asp Lys Ile Thr Glu Arg Ile Lys Glu Glu Met Ser Lys Asp Gln Pro
         275                 280                 285            
 Asp Tyr Ala Met Tyr Ser Arg Ile Ser Ser Ser Pro Thr His Ser Leu
     290                 295                 300                
 Tyr Val Phe Val Arg Asn Phe Val Cys Arg Ile Gly Glu Asp Ala Glu
 305                 310                 315                 320
 Leu Phe Met Ser Leu Tyr Asp Pro Asn Lys Gln Thr Val Ile Ser Glu
                 325                 330                 335    
 Asn Tyr Leu Val Arg Trp Gly Ser Arg Gly Phe Pro Lys Glu Ile Glu
             340                 345                 350        
 Met Leu Asn Asn Leu Lys Val Val Phe Thr Val Ser Val His Pro Leu
         355                 360                 365            
 Leu Val Thr Val Leu Pro Asn His Lys Asn Val Thr Leu Glu Met Arg
     370                 375                 380                
 Leu Asp Leu Gly Asn Lys Asp Leu Asn Arg Asp Lys Ile Tyr Leu Ile
 385                 390                 395                 400
 Cys Gln Ile Val Arg Val Gly Lys Met Asp Leu Lys Asp Thr Gly Ala
                 405                 410                 415    
 Lys Lys Cys Thr Gln Gly Leu Arg Arg Pro Phe Gly Val Ala Val Met
             420                 425                 430        
 Asp Ile Thr Asp Ile Ile Lys Gly Lys Ala Glu Ser Asp Glu Glu Lys
         435                 440                 445            
 Gln His Phe Ile Pro Phe His Pro Val Thr Ala Glu Asn Asp Phe Leu
     450                 455                 460                
 His Ser Leu Leu Gly Lys Val Ile Ala Ser Lys Gly Asp Ser Gly Gly
 465                 470                 475                 480
 Gln Gly Leu Trp Val Thr Met Lys Met Leu Val Gly Asp Ile Ile Gln
                 485                 490                 495    
 Ile Arg Lys Asp Tyr Pro His Leu Val Asp Arg Thr Thr Val Val Ala
             500                 505                 510        
 Arg Lys Leu Gly Phe Pro Glu Ile Ile Met Pro Gly Asp Val Arg Asn
         515                 520                 525            
 Asp Ile Tyr Ile Thr Leu Leu Gln Gly Asp Phe Asp Lys Tyr Asn Lys
     530                 535                 540                
 Thr Thr Gln Arg Asn Val Glu Val Ile Met Cys Val Cys Ala Glu Asp
 545                 550                 555                 560
 Gly Lys Thr Leu Pro Asn Ala Ile Cys Val Gly Ala Gly Asp Lys Pro
                 565                 570                 575    
 Met Asn Glu Tyr Arg Ser Val Val Tyr Tyr Gln Val Lys Gln Pro Arg
             580                 585                 590        
 Trp Met Glu Thr Val Lys Gly Arg Arg Met Glu Glu Leu Gly Gly Pro
         595                 600                 605            
 Cys Ile Ile Phe Phe Pro Asp Pro Thr Met Leu Phe Pro Ala Lys Asp
     610                 615                 620                
 Lys Gly Glu Lys Asn Phe Ala Met Ser Tyr Val Lys Leu Met Lys Glu
 625                 630                 635                 640
 Asp Gly Thr Thr Leu His Asp Gly Phe His Asp Leu Val Val Leu Lys
                 645                 650                 655    
 Ala Leu Cys Gly Ile Gly His Gly Ala Leu Ala Trp Gly Ser Asn Gln
             660                 665                 670        
 Val Leu Phe Pro Gly Gly Gln Gln Glu Asp Gly Gly Cys Gln Arg Ile
         675                 680                 685            
 Pro Asp Pro Ser Phe Leu Ser Thr Pro Cys Gly Lys Gln Gly Gly His
     690                 695                 700                
 Ala Glu Gln Glu Leu Gln Gln Cys Trp Gly Ala Phe Cys Gln Leu Pro
 705                 710                 715                 720
 Gly Cys Val Leu His Phe His Pro Val Gly Leu Leu Gly Leu Leu Lys
                 725                 730                 735    
 Trp Arg Met Lys Pro Gln Leu Leu Gln Glu Asn Leu Glu Lys Leu Lys
             740                 745                 750        
 Ile Val Asp Gly Glu Glu Val Val Lys Phe Leu Gln Asp Thr Leu Asp
         755                 760                 765            
 Ala Leu Phe Asn Ile Met Met Glu His Ser Gln Ser Asp Glu Tyr Asp
     770                 775                 780                
 Ile Leu Val Phe Asp Ala Leu Ile Tyr Ile Ile Gly Leu Ile Ala Asp
 785                 790                 795                 800
 Arg Lys Phe Gln His Phe Asn Thr Val Leu Glu Ala Tyr Ile Gln Gln
                 805                 810                 815    
 His Phe Ser Ala Thr Leu Ala Tyr Lys Lys Leu Met Thr Val Leu Lys
             820                 825                 830        
 Thr Tyr Leu Asp Thr Ser Ser Arg Gly Glu Gln Cys Glu Pro Ile Leu
         835                 840                 845            
 Arg Thr Leu Lys Ala Leu Glu Tyr Val Phe Lys Phe Ile Val Arg Ser
     850                 855                 860                
 Arg Thr Leu Phe Ser Gln Thr Lys His Gly Ile Leu Tyr Ser Asn His
 865                 870                 875                 880
 Ala Phe Val Asp Cys Pro Phe Leu Ala Gly Met Ser Asp Pro Ser Val
                 885                 890                 895    
 Gln Glu Pro Leu Thr Val Leu Tyr Ser Val Gly Met Asn Lys Glu Lys
             900                 905                 910        
 Leu Thr Gln Gly Arg Pro Gly Glu Leu Thr Leu Leu Gly Asn Lys Ser
         915                 920                 925            
 Leu Val Gly Glu Arg Lys Ile Ala Leu Cys Val Leu Met Gly Ala Ser
     930                 935                 940                
 Ala Pro Gly Ser Phe Ile Leu Leu Pro Thr Pro Glu Ser Arg Glu Ser
 945                 950                 955                 960
 Leu Pro Trp Cys Ala Gln Phe His Trp Pro Ala Leu Glu Leu Pro Pro
                 965                 970                 975    
 His
    



      <210> 1563
      <211> 139
      <212> PRT
      <213> Homo sapiens


      <400> 1563
 Met Ser Ser Arg Ser Ile His Thr Val Ala Gly Ile Arg Ala Leu Phe
   1               5                  10                  15    
 Leu Phe Met Ala Glu Ser Cys Ser Met Val Ala Phe Val Cys Ala Arg
              20                  25                  30        
 Pro Gly Val Ala Asn Phe Ser Ala Glu Ile Gln Met Ala Asn Val Leu
          35                  40                  45            
 Ala Phe Ala Gly Trp Thr Val Ser Ala Cys His Cys Ser Gly Lys Ala
      50                  55                  60                
 Thr Thr Ser Asn Met Ser Thr Ser Gly Cys Gly Arg Val Pro Ile Lys
  65                  70                  75                  80
 Gln Leu Cys Leu Ile Asn Ala Gly Gln Pro Cys Ser Leu Val Thr Ser
                  85                  90                  95    
 Val Gly His Trp Leu Leu Gly Val Phe Ser Ile Leu Pro Cys Ser Leu
             100                 105                 110        
 Leu Ala Pro Gly Glu Lys Gly Pro Tyr Arg Ser Leu Phe Gln Val Thr
         115                 120                 125            
 Arg Ser Cys Phe Leu Ala Thr Met Leu Arg Leu
     130                 135                



      <210> 1564
      <211> 109
      <212> PRT
      <213> Homo sapiens


      <400> 1564
 Met Asp Val Thr Arg Leu Leu Leu Ala Thr Leu Leu Val Phe Leu Cys
   1               5                  10                  15    
 Phe Phe Thr Ala Asn Ser His Leu Pro Pro Glu Glu Lys Leu Arg Asp
              20                  25                  30        
 Asp Arg Ser Leu Arg Ser Asn Ser Ser Val Asn Leu Leu Asp Val Pro
          35                  40                  45            
 Ser Val Ser Ile Val Ala Leu Asn Lys Lys Ser Lys Gln Ile Gly Arg
      50                  55                  60                
 Lys Ala Ala Glu Lys Lys Arg Ser Ser Lys Glu Lys Lys Gln Gln Ala
  65                  70                  75                  80
 Val Ala Ala Val Ser Lys Thr Ala Pro Ala Gly Phe Leu Gln Gln Glu
                  85                  90                  95    
 Leu Thr Cys Cys Val Arg Cys Thr Ala Gly Gln Arg Ser
             100                 105                



      <210> 1565
      <211> 583
      <212> PRT
      <213> Homo sapiens


      <400> 1565
 Met Gln Arg Leu Leu Thr Pro Val Lys Arg Ile Leu Gln Leu Thr Arg
   1               5                  10                  15    
 Ala Val Gln Glu Thr Ser Leu Thr Pro Ala Arg Leu Leu Pro Val Ala
              20                  25                  30        
 His Gln Arg Phe Ser Thr Ala Ser Ala Val Pro Leu Ala Lys Thr Asp
          35                  40                  45            
 Thr Trp Pro Lys Asp Val Gly Ile Leu Ala Leu Glu Val Tyr Phe Pro
      50                  55                  60                
 Ala Gln Tyr Val Asp Gln Thr Asp Leu Glu Lys Tyr Asn Asn Val Glu
  65                  70                  75                  80
 Ala Gly Lys Tyr Thr Val Gly Leu Gly Gln Thr Arg Met Gly Phe Cys
                  85                  90                  95    
 Ser Val Gln Glu Asp Ile Asn Ser Leu Cys Leu Thr Val Val Gln Arg
             100                 105                 110        
 Leu Met Glu Arg Ile Gln Leu Pro Trp Asp Ser Val Gly Arg Leu Glu
         115                 120                 125            
 Val Gly Thr Glu Thr Ile Ile Asp Lys Ser Lys Ala Val Lys Thr Val
     130                 135                 140                
 Leu Met Glu Leu Phe Gln Asp Ser Gly Asn Thr Asp Ile Glu Gly Ile
 145                 150                 155                 160
 Asp Thr Thr Asn Ala Cys Tyr Gly Gly Thr Ala Ser Leu Phe Asn Ala
                 165                 170                 175    
 Ala Asn Trp Met Glu Ser Ser Ser Trp Asp Gly Met Tyr Gly His Glu
             180                 185                 190        
 Pro Tyr Val Arg Lys Val Leu Glu Leu Glu Ala Glu Tyr Tyr Gln Phe
         195                 200                 205            
 Cys Phe Ser Val Pro Gln Met Tyr Ala Ser Leu Asp Val Arg Glu Lys
     210                 215                 220                
 Asn Thr Phe Ile Glu Thr Gly Pro Glu Asn His Lys Ile Asp Cys Arg
 225                 230                 235                 240
 Tyr Ala Met Val Val Cys Gly Asp Ile Ala Val Tyr Pro Ser Gly Asn
                 245                 250                 255    
 Ala Arg Pro Thr Gly Gly Ala Gly Ala Val Ala Met Leu Ile Gly Pro
             260                 265                 270        
 Lys Ala Pro Leu Ala Leu Glu Arg Gly Leu Val Tyr Gly Ala Glu Gly
         275                 280                 285            
 Gly Glu Glu Lys Trp Glu Arg Gly Ile Arg Glu Ala Ser Ser Leu Ala
     290                 295                 300                
 Ser Ser Gly Ile Gly Ile Thr Met His Gly Met Ser Gly Ala Asp Asp
 305                 310                 315                 320
 Gly Leu Arg Gly Thr His Met Glu Asn Val Tyr Asp Phe Tyr Lys Pro
                 325                 330                 335    
 Asn Leu Ala Ser Glu Tyr Pro Ile Val Asp Gly Lys Leu Ser Ile Gln
             340                 345                 350        
 Cys Tyr Leu Arg Ala Leu Asp Arg Cys Tyr Thr Ser Tyr Arg Lys Lys
         355                 360                 365            
 Ile Gln Asn Gln Trp Lys Gln Ala Gly Ser Asp Arg Pro Phe Thr Leu
     370                 375                 380                
 Asp Asp Leu Gln Tyr Met Ile Phe His Thr Pro Phe Cys Lys Met Val
 385                 390                 395                 400
 Gln Lys Ser Leu Ala Arg Leu Met Phe Asn Asp Phe Leu Ser Ala Ser
                 405                 410                 415    
 Ser Asp Thr Gln Thr Ser Leu Tyr Lys Gly Leu Glu Ala Phe Gly Gly
             420                 425                 430        
 Leu Lys Leu Glu Asp Thr Tyr Thr Asn Lys Asp Leu Asp Lys Ala Leu
         435                 440                 445            
 Leu Lys Ala Ser Gln Asp Met Phe Asp Lys Lys Thr Lys Ala Ser Leu
     450                 455                 460                
 Tyr Leu Ser Thr His Asn Gly Asn Met Tyr Thr Ser Ser Leu Tyr Gly
 465                 470                 475                 480
 Cys Leu Ala Ser Leu Leu Ser His His Ser Ala Gln Glu Leu Ala Gly
                 485                 490                 495    
 Ser Arg Ile Gly Ala Phe Ser Tyr Gly Ser Gly Leu Ala Ala Ser Phe
             500                 505                 510        
 Phe Ser Phe Arg Val Ser Gln Asp Ala Ala Pro Gly Ser Pro Leu Asp
         515                 520                 525            
 Lys Leu Val Ser Ser Thr Ser Asp Leu Pro Lys Arg Leu Ala Ser Arg
     530                 535                 540                
 Lys Cys Val Ser Pro Glu Glu Phe Thr Glu Ile Met Asn Gln Arg Glu
 545                 550                 555                 560
 Gln Phe Tyr His Lys Ala Trp Ser Gln Lys Glu Thr Glu Tyr Thr Glu
                 565                 570                 575    
 Leu Glu Met Phe Gln Lys Thr
             580            



      <210> 1566
      <211> 101
      <212> PRT
      <213> Homo sapiens


      <400> 1566
 Met Ala Leu Leu Gln Thr Leu Gly Pro Ser Thr Val Ala Leu Arg Ser
   1               5                  10                  15    
 Pro Gln Ser Ile Arg Gln Lys Leu Leu Asp Gln Asn Phe Arg Arg Trp
              20                  25                  30        
 Phe Pro Glu Ser Ala Val Lys Val Leu Ala Ser Gly Cys Leu Gln Asn
          35                  40                  45            
 Met Leu Leu Lys Ser Leu Gln Met Asp Pro Val Phe Trp Glu Ser Gln
      50                  55                  60                
 Gly Gly Ala Gln Gly Leu Lys Gln Val Leu Gln Thr Leu Glu Gln Arg
  65                  70                  75                  80
 Gly Gln Val Leu Leu Gly His Ile Gln Lys His Asn Leu Thr Leu Phe
                  85                  90                  95    
 Arg Asp Glu Asp Pro
             100    



      <210> 1567
      <211> 253
      <212> PRT
      <213> Homo sapiens


      <400> 1567
 Met Pro Gly Phe Lys Ser Leu Phe Phe Ser Ala Val Cys Ser Trp Val
   1               5                  10                  15    
 His Ser Ala His Pro Gln Val Ala Gly Phe Leu Gln Ala Trp His Val
              20                  25                  30        
 Gly Asn Lys Val Ala Thr Arg Asn Leu Ser Asp Pro Pro Pro Gln Gln
          35                  40                  45            
 Gly Asn Thr Ala Ser Gly His Tyr His Phe Thr Val Val Arg Asp Asn
      50                  55                  60                
 Val Lys Leu Gly Thr Ile Val Asn Met Leu Asp Asp Arg Tyr Ser Phe
  65                  70                  75                  80
 Leu Lys Asp Leu Ser Arg Gln Glu Glu Trp Ser Lys Cys Ser Asn Ser
                  85                  90                  95    
 Glu Asn Ser Ile Lys Ser His Met Ser Arg Lys Arg Gly Pro Glu Val
             100                 105                 110        
 Ser Arg Pro Ala Trp Gln Arg Lys Trp Phe Leu Glu Met Glu Ser Thr
         115                 120                 125            
 Pro Gly Glu Asp Ala Val Asn Ile Ile Glu Met Thr Thr Lys Asp Leu
     130                 135                 140                
 Asp Tyr Asp Leu Asn Leu Val Asp Lys Ala Ala Ala Gly Phe Lys Arg
 145                 150                 155                 160
 Ile Asp Ser Asn Phe Glu Arg Ser Ser Thr Val Gly Gly Asp Thr Lys
                 165                 170                 175    
 Met Ala Ile Glu Gly Phe Leu Glu Glu Gly Leu Glu Leu Gly Leu Lys
             180                 185                 190        
 Gly Gly Glu Lys Asp Tyr Leu Gly Thr Arg Val Phe Leu Met Phe Lys
         195                 200                 205            
 Trp Pro Asp Trp Asp Thr Ser Ala Ser Thr Ala Val Ser Glu Met Glu
     210                 215                 220                
 Gly Tyr Lys Lys Gln Asp Asn Val Ile Cys Gln Lys Pro Arg Cys Thr
 225                 230                 235                 240
 Asn Pro Phe Gly Pro Lys Leu Met Tyr Ser Ile Lys Pro
                 245                 250            



      <210> 1568
      <211> 187
      <212> PRT
      <213> Homo sapiens


      <400> 1568
 Met Ala Leu Arg Val Val Arg Ser Val Arg Ala Leu Leu Cys Thr Leu
   1               5                  10                  15    
 Arg Ala Val Pro Ser Pro Ala Ala Pro Cys Pro Pro Arg Pro Trp Gln
              20                  25                  30        
 Leu Gly Val Gly Ala Val Arg Thr Leu Arg Thr Gly Pro Ala Leu Leu
          35                  40                  45            
 Ser Gly Phe Pro Glu Ser Phe Asp Arg Ile Phe Arg Glu Val Leu Met
      50                  55                  60                
 Arg Lys Phe Thr Glu Lys His Glu Trp Val Thr Thr Glu Asn Gly Ile
  65                  70                  75                  80
 Gly Thr Val Gly Ile Ser Asn Phe Ala Gln Glu Ala Leu Gly Asp Val
                  85                  90                  95    
 Val Tyr Cys Ser Leu Pro Glu Val Gly Thr Lys Leu Asn Lys Gln Asp
             100                 105                 110        
 Glu Phe Gly Ala Leu Glu Ser Val Lys Ala Ala Ser Glu Leu Tyr Ser
         115                 120                 125            
 Pro Leu Ser Gly Glu Val Thr Glu Ile Asn Glu Ala Leu Ala Glu Asn
     130                 135                 140                
 Pro Gly Leu Val Asn Lys Ser Cys Tyr Glu Asp Gly Trp Leu Ile Lys
 145                 150                 155                 160
 Met Thr Leu Ser Asn Pro Ser Glu Leu Asp Glu Leu Met Ser Glu Glu
                 165                 170                 175    
 Ala Tyr Glu Lys Tyr Ile Lys Ser Ile Glu Glu
             180                 185        



      <210> 1569
      <211> 113
      <212> PRT
      <213> Homo sapiens


      <400> 1569
 Met Asp Gln Thr Leu Asn Ala Val Gly His Met Trp Ala Pro Val Val
   1               5                  10                  15    
 Ala Ile Tyr Phe Ile Leu Tyr His Leu Phe Ala Thr Leu Asn Glu Gly
              20                  25                  30        
 Leu Ser Pro Thr Pro Met Thr Phe His Thr Met Cys Trp Gln Val Ser
          35                  40                  45            
 Asp Thr Gln Val Asp Leu Leu Phe Gln Ser Lys Ser Thr Leu His Trp
      50                  55                  60                
 Ile Leu Leu Ser Leu Phe Val Ala Val Ile Leu Asp Asn Leu Glu Leu
  65                  70                  75                  80
 Asp Glu Asp Leu Lys Lys Leu Lys Gln Ile Glu Gly Gly Ser Lys Val
                  85                  90                  95    
 Ala Gly Ile Leu Leu Glu Asp Ala Ile Arg Leu Ser Thr Gly Cys Ile
             100                 105                 110        
 Ser
    



      <210> 1570
      <211> 439
      <212> PRT
      <213> Homo sapiens


      <400> 1570
 Met Asn His Phe Gly Thr Trp Leu Val Gly Gly Arg Val Thr Pro Leu
   1               5                  10                  15    
 Leu Pro Leu Lys Ala Arg Asn Asn Glu Asn Leu Asn Lys Ile Gly Ser
              20                  25                  30        
 Gly Val Tyr Val Gln Asp Cys Tyr Ile Gly Ile Leu Cys Asp Asp Ala
          35                  40                  45            
 Glu Met Val Ser Phe Gln Ala Ser Leu Glu Asp Glu Asn Gly Asp Met
      50                  55                  60                
 Phe Tyr Ser Gln Ala His Tyr Arg Ala Asn Glu Phe Gly Glu Val Asp
  65                  70                  75                  80
 Leu Asn His Ala Ser Ser Leu Gly Gly Asp Tyr Met Gly Val His Pro
                  85                  90                  95    
 Met Gly Leu Phe Trp Ser Leu Lys Pro Glu Lys Leu Leu Thr Arg Leu
             100                 105                 110        
 Leu Lys Arg Asp Val Met Asn Arg Pro Phe Gln Val Gln Val Lys Leu
         115                 120                 125            
 Tyr Asp Leu Glu Leu Ile Val Asn Asn Lys Val Ala Ser Ala Pro Lys
     130                 135                 140                
 Ala Ser Leu Thr Leu Glu Arg Trp Tyr Val Ala Pro Gly Val Thr Arg
 145                 150                 155                 160
 Ile Lys Val Arg Glu Gly Arg Leu Arg Gly Ala Leu Phe Leu Pro Pro
                 165                 170                 175    
 Gly Glu Gly Leu Phe Pro Gly Val Ile Asp Leu Phe Gly Gly Leu Gly
             180                 185                 190        
 Gly Leu Leu Glu Phe Arg Ala Ser Leu Leu Ala Ser Arg Gly Phe Ala
         195                 200                 205            
 Ser Leu Ala Leu Ala Tyr His Asn Tyr Glu Asp Leu Pro Arg Lys Pro
     210                 215                 220                
 Glu Val Thr Asp Leu Glu Tyr Phe Glu Glu Ala Ala Asn Phe Leu Leu
 225                 230                 235                 240
 Arg His Pro Lys Val Phe Gly Ser Gly Val Gly Val Val Ser Val Cys
                 245                 250                 255    
 Gln Gly Val Gln Ile Gly Leu Ser Met Ala Ile Tyr Leu Lys Gln Val
             260                 265                 270        
 Thr Ala Thr Val Leu Ile Asn Gly Thr Asn Phe Pro Phe Gly Ile Pro
         275                 280                 285            
 Gln Val Tyr His Gly Gln Ile His Gln Pro Leu Pro His Ser Ala Gln
     290                 295                 300                
 Leu Ile Ser Thr Asn Ala Leu Gly Leu Leu Glu Leu Tyr Arg Thr Phe
 305                 310                 315                 320
 Glu Thr Thr Gln Val Gly Ala Ser Gln Tyr Leu Phe Pro Ile Glu Glu
                 325                 330                 335    
 Ala Gln Gly Gln Phe Leu Phe Ile Val Gly Glu Gly Asp Lys Thr Ile
             340                 345                 350        
 Asn Ser Lys Ala His Ala Glu Gln Ala Ile Gly Gln Leu Lys Arg His
         355                 360                 365            
 Gly Lys Asn Asn Trp Thr Leu Leu Ser Tyr Pro Gly Ala Gly His Leu
     370                 375                 380                
 Ile Glu Pro Pro Tyr Ser Pro Leu Cys Cys Ala Ser Thr Thr His Asp
 385                 390                 395                 400
 Leu Arg Leu His Trp Gly Gly Glu Val Ile Pro His Ala Ala Ala Gln
                 405                 410                 415    
 Glu His Ala Trp Lys Glu Ile Gln Arg Phe Leu Arg Lys His Leu Ile
             420                 425                 430        
 Pro Asp Val Thr Ser Gln Leu
         435                



      <210> 1571
      <211> 129
      <212> PRT
      <213> Homo sapiens


      <400> 1571
 Met Ile Leu Ala Val Phe Pro Ala Arg Gln Pro Trp Cys Ser Ala Phe
   1               5                  10                  15    
 Leu Gly Phe Arg Ala Ile Leu Leu Leu Gly Phe Ser Ser Ser Ser Ala
              20                  25                  30        
 Pro Gln His Gln Glu Met Asn Thr Glu Ala Glu Gln Gln Leu Leu His
          35                  40                  45            
 His Ala Arg Asn Gly Asn Ala Glu Glu Val Arg Gln Leu Leu Glu Thr
      50                  55                  60                
 Met Ala Arg Asn Glu Val Ile Ala Asp Ile Asn Cys Lys Glu Ser Tyr
  65                  70                  75                  80
 Leu Glu Ile Leu Asp Val Arg Thr Pro Gly His Lys Leu Ser Glu Glu
                  85                  90                  95    
 Val Arg Gly Asp Ser Val Val Trp Met Gly Ala Asp Ala Val Ala Met
             100                 105                 110        
 Glu Lys Thr Arg Cys Asn Glu Tyr Leu Gly Val Gly Val Ser Arg Ala
         115                 120                 125            
 Asn
    



      <210> 1572
      <211> 701
      <212> PRT
      <213> Homo sapiens


      <400> 1572
 Met Ala Ala Leu Ala Thr Arg Ala Cys Ser Arg His Val Gly Phe Leu
   1               5                  10                  15    
 Gly Gln Leu Phe Gly Pro Met Met Glu Tyr Ala Ala Glu Pro His Arg
              20                  25                  30        
 Asn Asp Lys Pro Arg His Gln Gln Gly Lys Tyr Ser Thr Phe Glu Asp
          35                  40                  45            
 Ser Gly Ala Phe Phe Lys Lys Cys Val Arg Ile Asn Ala Met Arg Cys
      50                  55                  60                
 His Thr Leu Leu Ile Phe Ser Leu Pro Ser Ile Leu Leu Tyr Gln Leu
  65                  70                  75                  80
 Met Pro Asp Ile Met Arg Ala Val Thr Ile Thr Ile His Leu Arg Phe
                  85                  90                  95    
 Leu His Cys Ile Trp Arg Gly Leu Ser Ile Met Lys Ile Ile Asn Ile
             100                 105                 110        
 Ser Cys Glu Thr Glu Cys Thr Gly Asn Ser Ser Thr Val Gln Glu Gln
         115                 120                 125            
 Ile Leu Thr Glu Val Phe Thr Phe Thr Glu Pro Glu Ala Ala Asp Ser
     130                 135                 140                
 Ile Glu Ala Ala Val Lys Pro Val Ala Gly Ala Trp Glu Val Leu Glu
 145                 150                 155                 160
 Gly Asn Gln Tyr Ser Thr Arg Gln Arg Lys Pro Gly Asp Phe Gly Leu
                 165                 170                 175    
 Asn Gln Pro Arg Ala Leu Gly Met Ala Ala Ala Ala Gly Met Lys Arg
             180                 185                 190        
 Arg Asn Leu Val Val Gln Glu Val Met Gln Thr Gly His Ser Arg Ser
         195                 200                 205            
 Gly Cys Leu Arg Val Trp Leu Trp Leu Trp Gly Ser Arg Cys Glu Gly
     210                 215                 220                
 Ile Leu Arg Asn Leu Ser Pro Glu Ala Asp Gln Asp Ile Val Val Ala
 225                 230                 235                 240
 Arg Thr Ser Ala Leu Ser Ser Ser Pro Thr Tyr Pro Asp Leu Pro Phe
                 245                 250                 255    
 Ile Arg Ile Ser Pro His Arg Asn Pro Thr Ala Ala Ser Glu Ser Pro
             260                 265                 270        
 Phe Ser Pro Pro His Pro Tyr Ile Asn Pro Tyr Met Asp Tyr Ile Arg
         275                 280                 285            
 Ser Leu His Ser Ser Pro Ser Leu Ser Met Ile Ser Ala Thr Arg Gly
     290                 295                 300                
 Leu Ser Pro Thr Asp Gly Lys Ser Arg Met Asp Ser Ala Ser Gly Asp
 305                 310                 315                 320
 His Ala Ala Ser Ser Pro Leu Leu Thr Arg Asp Val Tyr Lys Val Asp
                 325                 330                 335    
 Leu Met Phe Thr Pro His Ala Gly Val Ser Pro Ala Glu Tyr Tyr His
             340                 345                 350        
 Gln Met Ala Leu Leu Thr Gly Gln Arg Ser Pro Tyr Ala Asp Ile Ile
         355                 360                 365            
 Pro Ser Ala Ala Thr Ala Gly Thr Gly Ala Ile His Met Glu Tyr Leu
     370                 375                 380                
 His Ala Met Asp Ser Thr Arg Phe Ser Ser Pro Arg Leu Ser Ala Arg
 385                 390                 395                 400
 Pro Ser Arg Lys Arg Thr Leu Ser Ile Ser Pro Leu Ser Asp His Ser
                 405                 410                 415    
 Phe Asp Leu Gln Thr Met Ile Arg Thr Ser Pro Asn Ser Leu Val Thr
             420                 425                 430        
 Ile Leu Asn Asn Ser Arg Ser Ser Ser Ser Ala Ser Gly Ser Tyr Gly
         435                 440                 445            
 His Leu Ser Ala Ser Ala Ile Ser Leu Leu Ser Pro Tyr Gly Leu Leu
     450                 455                 460                
 Val Ser Ser Ser Ser Pro Ser Pro Cys Ser Leu Ile Val Asp Val Asp
 465                 470                 475                 480
 Phe Arg Glu His Leu Phe Pro Ser Pro Gly Phe Thr Ser Lys Lys Val
                 485                 490                 495    
 Glu Ala Leu Asn Gly Asp Met Ala Lys Val Cys Glu Glu Leu Ser Glu
             500                 505                 510        
 Pro Leu Pro Leu Leu Pro Glu Asp Lys Glu Asp Arg Arg Pro Arg Lys
         515                 520                 525            
 Leu Arg Lys Asn Val Glu Ala Gly Val Asn Cys Val Thr Gly Ser Glu
     530                 535                 540                
 Met Asp Leu Ser Ser Cys Ile Ser Pro Asp Ser Asn Asn Leu Ala Gly
 545                 550                 555                 560
 Tyr Thr Ser Met Pro Ala Tyr Gly Phe Tyr His Leu Ala Leu Asp Trp
                 565                 570                 575    
 Asp Leu Asn Leu His Lys Met Asn Ser Gln Asn Asp Leu Tyr Trp His
             580                 585                 590        
 Cys Cys Glu Ala Ala Thr Gly Glu Gln Pro Glu Gly Thr Thr Leu Val
         595                 600                 605            
 Lys Glu Glu Gly Asp Lys Asp Glu Ser Lys Gln Glu Pro Glu Val Ile
     610                 615                 620                
 Tyr Glu Thr Asn Cys His Trp Glu Gly Cys Ala Arg Glu Phe Asp Thr
 625                 630                 635                 640
 Gln Glu Gln Leu Val His Pro Asn Pro Gln Gln His Asn Pro Ala Gly
                 645                 650                 655    
 Pro Leu Ala Ile Ala Leu Gly Asp Val Val Phe Tyr Leu Trp Gly Arg
             660                 665                 670        
 Thr Ala Glu Lys Val Arg Cys Ile Ser Val Ser Thr Gln Leu Gln Leu
         675                 680                 685            
 Gly Gly Val Gln Val Ser Val Ile Leu His Leu Ser Pro
     690                 695                 700    



      <210> 1573
      <211> 217
      <212> PRT
      <213> Homo sapiens


      <400> 1573
 Met Pro Arg Tyr Val Pro Leu Leu Leu Leu Leu Leu Leu Leu Arg Cys
   1               5                  10                  15    
 Ser Glu Arg Gly Gly Gly Val Asn Phe Gly Glu Lys Asp Ala Lys Val
              20                  25                  30        
 Pro Gly Thr Trp Arg Asp Gly Val Arg Val Pro Gly Glu Gly Ala Ser
          35                  40                  45            
 Trp Asp Ser Asp Arg Ala Ser Pro Glu Arg Arg Tyr Gly Ile Asp Pro
      50                  55                  60                
 Gly Thr Thr Lys Asp Ser Ile Thr Ala Asp Pro Arg Thr Thr Glu Asp
  65                  70                  75                  80
 Ser Val Thr Ala Asp Pro Gly Thr Thr Lys His Ser Ile Thr Val Asp
                  85                  90                  95    
 Pro Gly Thr Thr Glu Asp Ser Val Thr Ala Asp Pro Gly Thr Thr Lys
             100                 105                 110        
 His Ser Ile Thr Ala Asp Pro Gly Thr Thr Glu Asp Ser Val Thr Ala
         115                 120                 125            
 Asp Pro Gly Thr Thr Glu Asp Glu Thr Thr Lys His Val Thr Ala Val
     130                 135                 140                
 Lys Pro Thr Arg Leu Leu Thr Pro Met Gly Ile Ile Leu Ile Ser Leu
 145                 150                 155                 160
 Ala Ala Thr Thr Val Thr Val Val Leu Phe Val Gly Leu Gly Phe Ile
                 165                 170                 175    
 Val Arg Thr Tyr Lys Pro Val His Gly Tyr Glu Asn Thr Val Glu Ser
             180                 185                 190        
 His Val Asn Ser Phe Cys Leu Gln Gly Ala Trp Gln Lys Arg Met Asn
         195                 200                 205            
 Ile Ala Val Met Tyr Met Gln Thr Leu
     210                 215        



      <210> 1574
      <211> 388
      <212> PRT
      <213> Homo sapiens


      <400> 1574
 Met Gly Leu Arg Ala Gly Val Val Thr Ala Ser Lys Ala Phe Leu Ser
   1               5                  10                  15    
 Leu Ser Leu Glu Lys Gly Glu Ile Ser Gln Thr Met Asn Thr Gly Gly
              20                  25                  30        
 Glu Arg Glu Phe Gln Ala Glu Val Gln Lys Glu Gln Arg Gln Lys Ser
          35                  40                  45            
 Thr Gly Arg Tyr Gln Cys Ser Leu Arg Glu Val Gln Phe Cys Lys Lys
      50                  55                  60                
 Arg Met Phe Gln Ala Gly Asp Lys Ala Arg Arg Trp Glu Gly Ser Glu
  65                  70                  75                  80
 Glu Ser Phe Asp Ser Val Gly Ser Leu Gln Met Ala Ser Ser Leu Met
                  85                  90                  95    
 Met Lys Ile Ala Lys Thr Cys Ser Leu Gly Leu Asn Arg Leu Pro Glu
             100                 105                 110        
 Ala Lys Leu Lys Ala Phe Pro Thr Pro Arg Val Thr Ser Leu Cys Pro
         115                 120                 125            
 Gly Arg Gly Ser Arg Trp Pro Arg Ser Phe Pro Ala Gly Arg Lys Val
     130                 135                 140                
 Arg Glu Gln Gly Arg Trp Arg Ala Glu Pro Arg Gly Ala Ser Pro Ala
 145                 150                 155                 160
 Glu Gly Ser Ala Gly Arg Ala Arg Asp Ser Pro Arg Ser Leu Tyr Ser
                 165                 170                 175    
 Pro Arg Ser Leu Asp Pro Gln Gly Ala Ala Ala Glu Gly Gly Ala Ala
             180                 185                 190        
 Ala Thr Gly Ala Gly Ala Trp Ser Arg Arg Arg Gly Glu Ser Glu Asp
         195                 200                 205            
 Ala Ala Lys Arg Arg Arg Arg Gly Gly Ser Gln Pro Glu Arg Gly Ser
     210                 215                 220                
 Gly Gly Ala Cys Arg Arg Arg Ala Ala Arg Ala Ala Pro Gln Arg Lys
 225                 230                 235                 240
 Leu Ala Ala Ala Ala Ala Gly Ala Leu Ser Ala Ala Pro Arg Gly Pro
                 245                 250                 255    
 Pro Pro Leu Pro Ala Ala Pro Ala Pro Gly Pro Pro Cys Pro Ala Phe
             260                 265                 270        
 Pro Pro Pro Pro Leu Cys Gly Arg Gly Pro Gln Arg Pro Arg Ala Arg
         275                 280                 285            
 Pro Pro Gly Arg Pro Leu Ser Ala Cys Asp Phe Ser Asp Ala Ala Pro
     290                 295                 300                
 Pro Gly Val Arg Val Val Gly Leu Arg Pro Glu Arg Ala Gly Glu Thr
 305                 310                 315                 320
 Arg Arg Pro Arg Gly Ala Ala Pro Ala Arg Ala Gln Leu His Thr Cys
                 325                 330                 335    
 Asp Glu Ala Asn Asp Glu Val Ser Gln Arg Lys Val Ile Glu Asp Lys
             340                 345                 350        
 Asp Pro Phe Cys Gln Trp Asp Met Leu Gly Ile Pro Thr Ile Leu Val
         355                 360                 365            
 Thr Glu Cys Ala Trp Leu Val Leu Ala Ser Leu Pro Asp Ala Ser Lys
     370                 375                 380                
 Arg Arg Gln Lys
 385            



      <210> 1575
      <211> 737
      <212> PRT
      <213> Homo sapiens


      <400> 1575
 Met Leu Ile Ile His Trp Val Thr Val Val Thr Leu Glu Ala Thr Ile
   1               5                  10                  15    
 Ile Ile His Gln Val Thr Val Gly Thr Leu Glu Ala Thr Leu Ile Ile
              20                  25                  30        
 His Arg Val Thr Val Val Thr Arg Glu Ala Thr Ile Ile Ile Gln Gln
          35                  40                  45            
 Val Thr Val Asp Thr His Asn Ala Thr Ile Ile Ile His Gln Val Thr
      50                  55                  60                
 Val Val Thr Arg Glu Ala Thr Leu Ile Ile His Trp Val Thr Val Val
  65                  70                  75                  80
 Thr Asn Glu Ala Ile Leu Ile Ile His Arg Val Thr Val Val Thr His
                  85                  90                  95    
 Lys Ala Leu Leu Ile Leu His Gln Val Thr Val Val Thr His Glu Ala
             100                 105                 110        
 Ile Phe Ile Ile His Arg Val Thr Ala Val Thr His Lys Ala Ile Leu
         115                 120                 125            
 Ser Ile Arg Trp Val Met Val Val Thr His Glu Glu Ile Phe Ile Ile
     130                 135                 140                
 His Gln Val Thr Val Val Ile His Lys Glu Ile Leu Ile Ile Tyr Gln
 145                 150                 155                 160
 Val Thr Val Val Thr Gln Glu Ala Thr Leu Ile Ile His Gln Val Thr
                 165                 170                 175    
 Val Val Thr His Lys Ala Ile Leu Ser Val His Arg Val Thr Met Val
             180                 185                 190        
 Thr His Glu Ala Ile Leu Thr Ile His His Val Thr Val Val Thr His
         195                 200                 205            
 Glu Ala Thr Leu Ile Val His Trp Val Thr Val Val Thr His Glu Ala
     210                 215                 220                
 Thr Leu Ile Phe His Arg Val Thr Val Val Asn Cys Glu Ala Ile Leu
 225                 230                 235                 240
 Ile Phe Gln Gln Val Ser Val Val Thr Tyr Glu Ala Ile Leu Ile Ile
                 245                 250                 255    
 Gln Gln Ile Thr Val Val Thr Tyr Glu Ala Ile Leu Ile Ile His Gln
             260                 265                 270        
 Val Ala Val Val Thr Tyr Glu Ala Ile Leu Leu Ser Thr Thr Asp Leu
         275                 280                 285            
 Leu Asn Cys Cys His Gln Asn Thr Gly Ser Asp Met Asp Asn Glu Val
     290                 295                 300                
 Gln Ser Glu Glu Val Ser Glu Gly Asp Glu Glu Leu Thr Gly Asn Arg
 305                 310                 315                 320
 Ser Lys Gly Gln Phe Cys Tyr Gly Leu Val Lys Asn Leu Glu Ala Leu
                 325                 330                 335    
 Tyr Pro Cys Pro Arg Asp Leu Trp Asn Phe Asp Leu Glu Ser Asp Asp
             340                 345                 350        
 Leu Arg Val Glu Glu Leu Phe Leu Thr Gly Asn Ser Ser Val Arg Glu
         355                 360                 365            
 Thr Asp Gly Asp Glu Leu Val Arg Val Phe Phe Ile Leu Ile Ala Thr
     370                 375                 380                
 Leu Leu Arg Asp Ser Ile Leu Arg Ile Thr Cys Ile Trp Thr Ala Glu
 385                 390                 395                 400
 Ala Arg Cys Leu Glu Leu Leu Cys Met Val Gln Ala Ser Ser Pro Ile
                 405                 410                 415    
 His Ser Ser Val His Leu Leu Leu Ile Lys Phe His Ser Thr Cys His
             420                 425                 430        
 Arg Ala Thr Ser Arg Gln Leu Thr Glu Val Lys Gln Ala Ile Lys Cys
         435                 440                 445            
 Trp Thr Val Leu Thr Asn Val Glu Ser Leu His Pro Leu Ala Val Leu
     450                 455                 460                
 Arg His Val Ile Trp Ile Asp Gly Ala Gln Glu Phe Asn Val Val Ile
 465                 470                 475                 480
 Thr Val Val Leu Gly His Leu Leu Ser Ile Gly Phe Val Trp Ser Ala
                 485                 490                 495    
 Leu Asn Leu Ser Ile Ser Leu His Tyr Trp Asn Asn Ser Thr Lys Ser
             500                 505                 510        
 Leu Phe Pro Lys Thr Pro Leu Ile Ser Leu Lys Pro Leu Thr Glu Thr
         515                 520                 525            
 Glu Leu Arg Ile Lys Glu Ile Ile Glu Lys Leu Asp Gln Gln Ile Pro
     530                 535                 540                
 Pro Arg Pro Phe Thr His Val Asn Thr Thr Thr Ser Ala Thr His Ser
 545                 550                 555                 560
 Thr Ala Thr Ile Leu Asn Pro Arg Asp Thr Tyr Cys Arg Gly Asp Gln
                 565                 570                 575    
 Leu His Ile Leu Leu Glu Val Arg Asp His Leu Gly Arg Arg Lys Gln
             580                 585                 590        
 Tyr Gly Gly Asp Phe Leu Arg Ala Arg Met Ser Ser Pro Ala Leu Met
         595                 600                 605            
 Ala Gly Ala Ser Gly Lys Val Thr Asp Phe Asn Asn Gly Thr Tyr Leu
     610                 615                 620                
 Val Ser Phe Thr Leu Phe Trp Glu Gly Gln Val Ser Leu Ser Leu Leu
 625                 630                 635                 640
 Leu Ile His Pro Ser Glu Gly Val Ser Ala Leu Trp Ser Ala Arg Asn
                 645                 650                 655    
 Gln Gly Tyr Asp Arg Val Ile Phe Thr Gly Gln Phe Val Asn Gly Thr
             660                 665                 670        
 Ser Gln Val His Ser Glu Cys Gly Leu Ile Leu Asn Thr Asn Ala Glu
         675                 680                 685            
 Leu Cys Gln Tyr Leu Asp Asn Arg Asp Gln Glu Gly Phe Tyr Cys Val
     690                 695                 700                
 Arg Pro Gln His Met Pro Cys Ala Ala Leu Thr His Met Tyr Ser Lys
 705                 710                 715                 720
 Asn Lys Lys Val Ser Tyr Leu Ser Lys Gln Glu Lys Ser Leu Phe Glu
                 725                 730                 735    
 Arg
    



      <210> 1576
      <211> 803
      <212> PRT
      <213> Homo sapiens


      <400> 1576
 Met Ala Val Tyr Val Cys Val Gly Val Ser Leu Thr Thr Val Leu Thr
   1               5                  10                  15    
 Gln Phe Pro Leu Val Glu Val Lys Lys Tyr Ser Val Ala Lys Gly Thr
              20                  25                  30        
 Glu Glu Arg Asn Ile Thr Val Glu Lys Leu Val Tyr Thr Asn Phe Thr
          35                  40                  45            
 Arg Arg Ser Gly Pro Thr Leu Thr Ala Ser Gln Thr Ala Gly Ile Thr
      50                  55                  60                
 Gly Val Asn His Arg Thr Arg Pro Arg Ile Ser Leu Asp Leu Gln Asn
  65                  70                  75                  80
 Arg Asn Gly Phe Leu Gly Glu Gly Pro Lys Lys Cys Glu Ser Lys Gln
                  85                  90                  95    
 Arg Phe Gly Asn His Gln Ala Cys Ile Val Pro Val Pro Asp Pro Gly
             100                 105                 110        
 Phe Val Ala Tyr Ile Phe Lys Glu Asp Ser Trp Ala Thr Thr Asp Thr
         115                 120                 125            
 Ala Leu Ser Ile Ala Ile Phe Asp Asp Lys Gln Met Pro Ser Val Gly
     130                 135                 140                
 Lys Ala Ala Gln Asp His Ser Ser Thr His Arg Val Arg Arg His Arg
 145                 150                 155                 160
 Thr His Pro His Ser Leu Asn Tyr Leu Thr Ala Gly Glu Pro Gln Ser
                 165                 170                 175    
 Cys Pro Gly Arg Ala Gly Ala Glu Arg Glu Pro Tyr Leu Glu Ile Ile
             180                 185                 190        
 Asp Thr Arg Arg Arg Ala Pro Gln Gln Thr Trp Asp Pro Glu Pro Arg
         195                 200                 205            
 Ala Leu Ala His Pro Cys Met Leu Glu Asp Lys Thr Arg Gly His Pro
     210                 215                 220                
 Ser Val Phe Ser Ser Ala Gln Pro Gln Asp Thr Pro Lys Ala Thr Val
 225                 230                 235                 240
 Cys Glu Arg Gly Ser Gln His Val Ser Gly Asp Ala Ser Arg Pro Leu
                 245                 250                 255    
 Pro Glu Ala Leu Leu Pro Pro Lys Gln Gln His Leu Arg Leu Gln Thr
             260                 265                 270        
 Ala Thr Met Glu Thr Ser Arg Ser Pro Ser Pro Gln Phe Ala Pro Gln
         275                 280                 285            
 Lys Leu Thr Asp Lys Pro Pro Leu Leu Ile Gln Asp Glu Asp Ser Thr
     290                 295                 300                
 Arg Tyr Cys Pro Ala Thr Val Gln Ala Ile Leu Met Leu Gln Leu Pro
 305                 310                 315                 320
 Glu Ile Glu Arg Val Met Asp Asn Asn Thr Thr Val Lys Met Val Pro
                 325                 330                 335    
 Ile Lys Ile Val His Ser Glu Ser Gln Pro Glu Lys Glu Ser Arg Gln
             340                 345                 350        
 Ser Leu Ala Cys Pro Ala Glu Pro Pro Ala Leu Pro His Gly Leu Glu
         355                 360                 365            
 Lys Asp Gln Ile Lys Thr Leu Ser Thr Ser Glu Gln Phe Tyr Ser Arg
     370                 375                 380                
 Phe Cys Leu Tyr Thr Arg Gln Gly Ala Glu Pro Glu Ala Pro His Arg
 385                 390                 395                 400
 Ala Gln Pro Ala Glu Pro Gln Pro Leu Gly Thr Gln Val Pro Pro Glu
                 405                 410                 415    
 Lys Asp Arg Cys Thr Ser Pro Pro Gly Leu Ser Tyr Met Lys Ala Lys
             420                 425                 430        
 Glu Lys Thr Val Glu Asp Leu Lys Ser Glu Glu Leu Ala Arg Glu Ile
         435                 440                 445            
 Val Gly Lys Asp Lys Ser Leu Ala Asp Ile Leu Asp Pro Ser Val Lys
     450                 455                 460                
 Ile Lys Thr Thr Met Asp Leu Met Glu Gly Ile Phe Pro Lys Asp Glu
 465                 470                 475                 480
 His Leu Leu Glu Glu Ala Gln Gln Arg Arg Lys Leu Leu Pro Lys Ile
                 485                 490                 495    
 Pro Ser Pro Arg Ser Thr Glu Glu Arg Lys Glu Glu Pro Ser Val Pro
             500                 505                 510        
 Ala Ala Val Ser Leu Ala Thr Asn Ser Thr Tyr Tyr Ser Thr Ser Ala
         515                 520                 525            
 Pro Lys Ala Glu Leu Leu Ile Lys Met Lys Asp Leu Gln Glu Gln Gln
     530                 535                 540                
 Glu His Glu Glu Asp Ser Gly Ser Asp Leu Asp His Asp Leu Ser Val
 545                 550                 555                 560
 Lys Lys Val Arg Gln Gly Gly Ser Glu Gln Cys Gly Arg Gly Gly Gly
                 565                 570                 575    
 Arg Pro Asn Gln Cys Leu Arg Val Pro Leu Pro Ser Arg Ala Gln Gln
             580                 585                 590        
 Gln Glu Leu Ile Glu Ser Ile Ser Arg Lys Leu Gln Val Leu Arg Glu
         595                 600                 605            
 Ala Arg Glu Ser Leu Leu Glu Asp Val Gln Ala Asn Thr Val Leu Gly
     610                 615                 620                
 Ala Glu Val Glu Ala Ile Val Lys Gly Val Cys Lys Pro Ser Glu Phe
 625                 630                 635                 640
 Asp Lys Phe Arg Met Phe Ile Gly Asp Leu Asp Lys Val Val Asn Leu
                 645                 650                 655    
 Leu Leu Ser Leu Ser Gly Arg Leu Ala Arg Val Glu Asn Ala Leu Asn
             660                 665                 670        
 Asn Leu Asp Asp Gly Ala Ser Pro Gly Asp Arg Val Arg Val Ile Trp
         675                 680                 685            
 Ala Thr Gln Asn Ala Val Leu Ala Leu Gly Leu Glu Thr Val Pro Phe
     690                 695                 700                
 Cys Thr Gln Pro Ser Leu Phe Val Cys Gln Gln Gln Ser Leu Leu Glu
 705                 710                 715                 720
 Lys Gln Arg Val Leu Ile Gln Gln His Glu Asp Ala Lys Glu Leu Lys
                 725                 730                 735    
 Glu Asn Leu Asp Arg Arg Glu Arg Ile Val Phe Asp Ile Leu Ala Asn
             740                 745                 750        
 Tyr Leu Ser Glu Glu Ser Leu Ala Asp Tyr Glu His Phe Val Lys Met
         755                 760                 765            
 Lys Ser Ala Leu Ile Ile Glu Gln Arg Glu Leu Glu Asp Lys Ile His
     770                 775                 780                
 Leu Gly Glu Glu Gln Leu Lys Cys Leu Leu Asp Ser Leu Gln Pro Glu
 785                 790                 795                 800
 Arg Gly Lys
            



      <210> 1577
      <211> 806
      <212> PRT
      <213> Homo sapiens


      <400> 1577
 Met Ser Phe Leu Leu Ser Ser Leu Leu Ala Leu Leu Thr Val Ser Thr
   1               5                  10                  15    
 Pro Ser Trp Cys Gln Ser Thr Glu Ala Ser Pro Lys Arg Ser Asp Gly
              20                  25                  30        
 Thr Pro Phe Pro Trp Asn Lys Ile Arg Leu Pro Glu Tyr Val Ile Pro
          35                  40                  45            
 Val His Tyr Asp Leu Leu Ile His Ala Asn Leu Thr Thr Leu Thr Phe
      50                  55                  60                
 Trp Gly Thr Thr Lys Val Glu Ile Thr Ala Ser Gln Pro Thr Ser Thr
  65                  70                  75                  80
 Ile Ile Leu His Ser His His Leu Gln Ile Ser Arg Ala Thr Leu Arg
                  85                  90                  95    
 Lys Gly Ala Gly Glu Arg Leu Ser Glu Glu Pro Leu Gln Val Leu Glu
             100                 105                 110        
 His Pro Arg Gln Glu Gln Ile Ala Leu Leu Ala Pro Glu Pro Leu Leu
         115                 120                 125            
 Val Gly Leu Pro Tyr Thr Val Val Ile His Tyr Ala Gly Asn Leu Ser
     130                 135                 140                
 Glu Thr Phe His Gly Phe Tyr Lys Ser Thr Tyr Arg Thr Lys Glu Gly
 145                 150                 155                 160
 Glu Leu Ser Ser Thr Leu His Cys Gln Ile Ile Leu Lys Pro Val Phe
                 165                 170                 175    
 Lys Glu Lys Trp Ile Ser His Ile Leu Ala Lys Leu Thr Ile Ser Val
             180                 185                 190        
 Leu Leu Cys Leu Ile Arg Val Ile Asn Pro His Met Pro Asn Val Asp
         195                 200                 205            
 Leu Gln Cys Ile Val Asn Phe Lys Met Val Lys Ser Val Thr Val Ala
     210                 215                 220                
 Glu Gly Leu Ile Glu Asp His Phe Asp Val Thr Val Lys Met Ser Thr
 225                 230                 235                 240
 Tyr Leu Val Ala Phe Ile Ile Ser Asp Phe Glu Ser Val Ser Lys Ile
                 245                 250                 255    
 Thr Lys Ser Gly Val Lys Val Ser Val Tyr Ala Val Pro Asp Lys Ile
             260                 265                 270        
 Asn Gln Ala Asp Tyr Ala Leu Asp Ala Ala Val Thr Leu Leu Glu Phe
         275                 280                 285            
 Tyr Glu Asp Tyr Phe Ser Ile Pro Tyr Pro Leu Pro Lys Gln Asp Leu
     290                 295                 300                
 Ala Ala Ile Pro Asp Phe Gln Ser Gly Ala Met Glu Asn Trp Gly Leu
 305                 310                 315                 320
 Thr Thr Tyr Arg Glu Ser Ala Leu Leu Phe Asp Ala Glu Lys Ser Ser
                 325                 330                 335    
 Ala Ser Ser Lys Leu Gly Ile Thr Met Thr Val Ala His Glu Leu Ala
             340                 345                 350        
 His Gln Gly Asp Tyr Phe Phe Gly Lys Cys Phe Asp Ala Met Glu Val
         355                 360                 365            
 Asp Ala Leu Asn Ser Ser His Pro Val Ser Thr Pro Val Glu Asn Pro
     370                 375                 380                
 Ala Gln Ile Arg Glu Met Phe Asp Asp Val Ser Tyr Asp Lys Gly Ala
 385                 390                 395                 400
 Cys Ile Leu Asn Met Leu Arg Glu Tyr Leu Ser Ala Asp Ala Phe Lys
                 405                 410                 415    
 Ser Gly Ile Val Gln Tyr Leu Gln Lys His Ser Tyr Lys Asn Thr Lys
             420                 425                 430        
 Asn Glu Asp Leu Trp Asp Ser Asn Ile Cys Leu Val Gly Trp Asn Leu
         435                 440                 445            
 Ala Phe Glu Ile Met Pro Leu Pro Leu Leu Leu Lys Tyr Phe Ser Cys
     450                 455                 460                
 Ile Cys Val Ser Tyr Glu Val Asp Leu Tyr Ser Leu Pro Pro Ser Ser
 465                 470                 475                 480
 Gln Tyr Leu Trp His Val Pro Leu Thr Phe Ile Thr Ser Lys Ser Asp
                 485                 490                 495    
 Met Val His Arg Phe Leu Leu Lys Thr Lys Thr Asp Val Leu Ile Leu
             500                 505                 510        
 Pro Glu Glu Val Glu Trp Ile Lys Phe Asn Val Gly Met Asn Gly Tyr
         515                 520                 525            
 Tyr Ile Val His Tyr Glu Asp Asp Gly Trp Asp Ser Leu Thr Gly Leu
     530                 535                 540                
 Leu Lys Gly Thr His Thr Ala Val Ser Ser Asn Asp Arg Ala Ser Leu
 545                 550                 555                 560
 Ile Asn Asn Ala Phe Gln Leu Val Ser Ile Gly Lys Leu Ser Ile Glu
                 565                 570                 575    
 Lys Ala Leu Asp Leu Ser Leu Tyr Leu Lys His Glu Thr Glu Ile Met
             580                 585                 590        
 Pro Val Phe Gln Gly Leu Asn Glu Leu Ile Pro Met Tyr Lys Leu Met
         595                 600                 605            
 Glu Lys Arg Asp Met Asn Glu Val Glu Thr Gln Phe Lys Ala Phe Leu
     610                 615                 620                
 Ile Arg Leu Leu Arg Asp Leu Ile Asp Lys Gln Thr Trp Thr Asp Glu
 625                 630                 635                 640
 Gly Ser Val Ser Glu Arg Met Leu Arg Ser Gln Leu Leu Leu Leu Ala
                 645                 650                 655    
 Cys Val His Asn Tyr Gln Pro Cys Val Gln Arg Ala Glu Gly Tyr Phe
             660                 665                 670        
 Arg Lys Trp Lys Glu Ser Asn Gly Asn Leu Ser Leu Pro Val Asp Val
         675                 680                 685            
 Thr Leu Ala Val Phe Ala Val Gly Ala Gln Ser Thr Glu Gly Trp Asp
     690                 695                 700                
 Phe Leu Tyr Ser Lys Tyr Gln Phe Ser Leu Ser Ser Thr Glu Lys Ser
 705                 710                 715                 720
 Gln Ile Glu Phe Ala Leu Cys Arg Thr Gln Asn Lys Glu Lys Leu Gln
                 725                 730                 735    
 Trp Phe Glu Leu Gly Ser Ser Ser Ile Ala His Met Val Met Gly Thr
             740                 745                 750        
 Thr Asn Gln Phe Ser Thr Arg Thr Arg Leu Glu Glu Thr Ile Glu Thr
         755                 760                 765            
 Ile Glu Glu Asn Ile Gly Trp Met Asp Lys Asn Phe Asp Lys Ile Arg
     770                 775                 780                
 Val Trp Leu Gln Ser Glu Lys Leu Glu Arg Ala Leu Glu Leu Glu Ala
 785                 790                 795                 800
 Ala Phe Leu His Leu Ser
                 805    



      <210> 1578
      <211> 685
      <212> PRT
      <213> Homo sapiens


      <400> 1578
 Met Lys Ile Leu Asp Trp Pro Ser Leu Pro Val Tyr Ile Phe Leu Pro
   1               5                  10                  15    
 Trp Trp Met Leu Pro Ala Leu Glu His Leu Thr Pro Ser Ser Ser Ile
              20                  25                  30        
 Leu Gly Leu Glu Leu Ala Ile Leu Ala Pro Gln Leu Ala Asp Ser Leu
          35                  40                  45            
 Leu Arg Asp Leu Val Ile Ile Glu Gly Asn Phe Leu Cys Glu Glu Glu
      50                  55                  60                
 Ile Leu Glu Ser Leu Arg Val Lys Lys Ala Ala Leu Asn Val Leu Val
  65                  70                  75                  80
 Asp Leu Leu Pro Gly Cys Val Tyr Thr Val Ala Ala Asp Leu Tyr Leu
                  85                  90                  95    
 Gln Pro Cys Arg Lys Glu Pro Leu Leu Lys Thr Asn Gly Ile Thr Phe
             100                 105                 110        
 Gln Gln Ser Trp Cys Gln Val Leu Glu Ser Arg Ala Thr Phe Asp Asn
         115                 120                 125            
 Phe Thr Gln Phe Thr Pro Ala Asp Ser Pro Gln Val Arg Lys Glu Cys
     130                 135                 140                
 Gly Lys Tyr Leu Pro Thr Arg Phe His Leu Arg Tyr Val Ser Ala Val
 145                 150                 155                 160
 Pro Gly Lys Pro His Thr Val Thr Gly Trp Ile Leu Thr Thr Val Val
                 165                 170                 175    
 Thr Phe Ser Ala Asn Cys Ser Leu Leu Thr Val Thr Ser Pro Arg Leu
             180                 185                 190        
 Gly Lys Ile Asn Leu Lys Asn Val Gly Gly Gly Glu Gly Arg Ala Pro
         195                 200                 205            
 Ser Ala Arg Met Leu Gly Phe Pro Phe Leu Arg Leu Gly Ile Pro Asn
     210                 215                 220                
 Leu Pro Asn Pro Pro Pro Asn Pro Glu Lys Pro Phe Ser Leu Leu Pro
 225                 230                 235                 240
 Thr Gly Pro Arg Gln Arg Ile Gly Thr Lys Thr Ala Arg Ser Ile His
                 245                 250                 255    
 Pro Gly Pro Asp Thr His Val Arg Gly Ser His Leu Leu Thr Cys Ile
             260                 265                 270        
 Ser Gln Leu His Ser Arg Tyr Val Asp Leu Pro Val Ala Glu Pro Ala
         275                 280                 285            
 Glu Glu Thr Gln Arg His Gly Lys Asn Thr Lys Leu Arg Thr Val Glu
     290                 295                 300                
 Cys Glu Ser His Phe Cys Leu Leu Leu Leu Leu Arg Pro Trp Ala Ser
 305                 310                 315                 320
 His Ser Thr Ser Gln Asn Leu Asp Phe Leu Leu Val Thr Ala Leu Ser
                 325                 330                 335    
 Ser Ser Asn Asn Pro Gln Gly Ser Leu Lys Lys Leu Thr Ile Met Val
             340                 345                 350        
 Glu Gly Lys Gly Gly Ala Gly Thr Ser Tyr Gly Glu Asn Arg Asn Arg
         355                 360                 365            
 Gln Glu Arg Met Glu Asp Glu Gly Gly Ser Glu Ile Leu Ile Lys Arg
     370                 375                 380                
 Asp Leu Ser Pro His Arg Arg Gly Met Val Pro Asn Gly Gln Ala Ser
 385                 390                 395                 400
 Trp Ala Leu Arg Pro His Ser Gln Lys Pro Gly Ser Ile Gly Arg Ser
                 405                 410                 415    
 Ala Arg Met Gly Val Gly Ile Glu Glu Ile Gly Asp Ile Ala Ala Asp
             420                 425                 430        
 Ala Arg Tyr Arg Glu Arg Arg Val Arg Arg Cys Arg Asp Val Ala Leu
         435                 440                 445            
 Leu Leu Phe Gly Arg Ser Leu Pro Gln Cys Gln Ala Cys Glu Met Gly
     450                 455                 460                
 Val Lys Pro Val Pro Pro Arg Glu Asp Arg Ala Trp Gly Ser Arg Ala
 465                 470                 475                 480
 Asp Gly Leu Pro Phe Pro Gly Cys Pro Lys Gly Leu Gly Gly Cys Gly
                 485                 490                 495    
 Thr Ala Cys Arg Ser Arg Ser Arg Ala Arg Leu Leu Lys Ser Ser Gln
             500                 505                 510        
 Arg Arg Gly Trp Lys Gln Tyr Arg Arg Pro Arg Leu Ser Leu Pro Gly
         515                 520                 525            
 Leu Val Gln Ala Leu Lys Leu Gln Gln Leu Arg Lys Glu Ser Leu Trp
     530                 535                 540                
 Glu Asn Leu Leu Glu Gly Arg Met Trp Arg Ser Ala Pro Trp Gly Asp
 545                 550                 555                 560
 Glu Glu Gly Glu Ala Leu Ala Gly Gly Pro Ala Lys Pro Leu Ser Ser
                 565                 570                 575    
 Asp Gly Glu Glu Arg Glu Arg His Glu Ala Thr Ser Phe Val Pro Phe
             580                 585                 590        
 Arg Phe Gly Leu Gly Arg Gln Asp Thr Glu Gly Phe Phe Leu Ser Leu
         595                 600                 605            
 Pro Ser Leu Thr Leu Leu Ser Asn Asp Phe Ser Leu Asp Pro Gly Gly
     610                 615                 620                
 Arg Arg Glu Arg Ala Thr Asp Cys Leu Leu Arg Phe Cys Ser Ser Ser
 625                 630                 635                 640
 Phe Gln Pro Pro Arg Leu Cys Arg Arg Leu Ser Glu Ala Lys Pro Gln
                 645                 650                 655    
 Thr Leu Gly Leu Arg Val Pro Glu Lys Gly Ile Leu Val Phe Pro Pro
             660                 665                 670        
 Pro Pro Pro Leu Arg Arg Ile Pro Ala Trp Ser Thr Leu
         675                 680                 685



      <210> 1579
      <211> 940
      <212> PRT
      <213> Homo sapiens


      <400> 1579
 Met Val Ala Cys Tyr Leu Asp Val Leu Thr Thr Trp Gln Leu Ala Phe
   1               5                  10                  15    
 Leu Arg Ala Leu Ser Cys Asp Cys Ala Glu Gln Ala Glu Ala Glu Leu
              20                  25                  30        
 Trp Ile Glu Leu Leu Asn Ala Cys Cys Leu Ala Asn Gln Thr Thr Glu
          35                  40                  45            
 Trp Gln Lys Thr Lys Ala Phe Lys Met Ala Tyr Val Met Asp Arg Ile
      50                  55                  60                
 Leu Ser Ser Pro Asn Leu Cys Val Glu Val Leu Thr Pro His Thr Pro
  65                  70                  75                  80
 Gln Asn Val Ala Val Phe Gly Asp Trp Thr Phe Lys Glu Cys Phe Glu
                  85                  90                  95    
 Ile Cys Asp Gly Lys Leu Lys Trp Lys Glu Asn Lys Tyr Ile Glu Asp
             100                 105                 110        
 Glu Lys Arg Ile Met Glu Arg Lys Lys Ser Glu Glu Lys Ile Lys Thr
         115                 120                 125            
 Gln Leu Ala Leu Gln Gln Leu Asn Ala Val Ala Ser His Gly Ser Thr
     130                 135                 140                
 Pro Pro Tyr Thr Leu Leu Asn Gln Ala Phe Leu Lys Ile Ala Met Ser
 145                 150                 155                 160
 Arg Pro Arg Phe Asn Pro Arg Gly Asp Phe Pro Leu Gln Arg Pro Arg
                 165                 170                 175    
 Ala Pro Asn Pro Ser Gly Met Arg Pro Pro Gly Pro Phe Met Arg Pro
             180                 185                 190        
 Gly Ser Met Gly Leu Pro Arg Phe Tyr Pro Ala Gly Arg Ala Arg Gly
         195                 200                 205            
 Ile Pro His Arg Phe Ala Gly His Glu Ser Tyr Gln Asn Met Gly Pro
     210                 215                 220                
 Gln Arg Met Asn Val Gln Val Thr Gln His Arg Thr Asp Pro Arg Leu
 225                 230                 235                 240
 Thr Lys Glu Lys Leu Asp Phe His Glu Ala Gln Gln Lys Lys Gly Lys
                 245                 250                 255    
 Pro His Gly Ser Arg Trp Asp Asp Glu Pro His Ile Ser Ala Ser Val
             260                 265                 270        
 Ala Val Lys Gln Ser Ser Val Thr Gln Val Thr Glu Gln Ser Pro Lys
         275                 280                 285            
 Val Gln Ser Arg Tyr Thr Lys Glu Ser Ala Ser Ser Ile Leu Ala Ser
     290                 295                 300                
 Phe Gly Leu Ser Asn Glu Asp Leu Glu Glu Leu Ser Arg Tyr Pro Asp
 305                 310                 315                 320
 Glu Gln Leu Thr Pro Glu Asn Met Pro Leu Ile Leu Arg Asp Ile Arg
                 325                 330                 335    
 Met Arg Lys Met Gly Arg Arg Leu Pro Asn Leu Pro Ser Gln Ser Arg
             340                 345                 350        
 Asn Lys Glu Thr Leu Gly Ser Glu Ala Val Ser Ser Asn Val Ile Asp
         355                 360                 365            
 Tyr Gly His Ala Ser Lys Tyr Gly Tyr Thr Glu Asp Pro Leu Glu Val
     370                 375                 380                
 Arg Ile Tyr Asp Pro Glu Ile Pro Thr Asp Glu Val Glu Asn Glu Phe
 385                 390                 395                 400
 Gln Ser Gln Gln Asn Ile Ser Ala Ser Val Pro Asn Pro Asn Val Ile
                 405                 410                 415    
 Cys Asn Ser Met Phe Pro Val Glu Asp Val Phe Arg Gln Met Asp Phe
             420                 425                 430        
 Pro Gly Glu Ser Ser Asn Asn Arg Ser Phe Phe Ser Val Glu Ser Gly
         435                 440                 445            
 Thr Lys Met Ser Gly Leu His Ile Ser Gly Gly Gln Ser Val Leu Glu
     450                 455                 460                
 Pro Ile Lys Ser Val Asn Gln Ser Ile Asn Gln Thr Val Ser Gln Thr
 465                 470                 475                 480
 Met Ser Gln Ser Leu Ile Pro Pro Ser Met Asn Gln Gln Pro Phe Ser
                 485                 490                 495    
 Ser Glu Leu Ile Ser Ser Val Ser Gln Gln Glu Arg Ile Pro His Glu
             500                 505                 510        
 Pro Val Ile Asn Ser Ser Asn Val His Val Gly Ser Arg Gly Ser Lys
         515                 520                 525            
 Lys Asn Tyr Gln Ser Gln Ala Asp Ile Pro Ile Arg Ser Pro Phe Gly
     530                 535                 540                
 Ile Val Lys Ala Ser Trp Leu Pro Lys Phe Ser His Ala Asp Ala Gln
 545                 550                 555                 560
 Lys Met Lys Arg Leu Pro Thr Pro Ser Met Met Asn Asp Tyr Tyr Ala
                 565                 570                 575    
 Ala Ser Pro Arg Ile Phe Pro His Leu Cys Ser Leu Cys Asn Val Glu
             580                 585                 590        
 Cys Ser His Leu Lys Asp Trp Ile Gln His Gln Asn Thr Ser Thr His
         595                 600                 605            
 Ile Glu Ser Cys Arg Gln Leu Arg Gln Gln Asn Glu Gly Asn Arg Lys
     610                 615                 620                
 Glu Asn Glu Thr Pro Arg Arg Arg Ser His Ser Pro Ser Pro Arg Arg
 625                 630                 635                 640
 Ser Arg Arg Ser Ser Ser Ser His Arg Phe Arg Arg Ser Arg Ser Pro
                 645                 650                 655    
 Met His Tyr Met Tyr Arg Pro Arg Ser Arg Ser Pro Arg Ile Cys His
             660                 665                 670        
 Arg Phe Ile Ser Arg Tyr Arg Ser Arg Ser Arg Ser Arg Ser Pro Tyr
         675                 680                 685            
 Arg Ile Arg Asn Pro Phe Arg Gly Ser Pro Lys Cys Phe Arg Ser Val
     690                 695                 700                
 Ser Pro Glu Arg Met Ser Arg Arg Ser Val Arg Ser Ser Asp Arg Lys
 705                 710                 715                 720
 Lys Ala Leu Glu Asp Val Val Gln Arg Ser Gly His Gly Thr Glu Phe
                 725                 730                 735    
 Asn Lys Gln Lys His Leu Glu Ala Ala Asp Lys Gly His Ser Pro Ala
             740                 745                 750        
 Gln Lys Pro Lys Thr Ser Ser Gly Thr Lys Pro Ser Val Lys Pro Thr
         755                 760                 765            
 Ser Ala Thr Lys Ser Asp Ser Asn Leu Gly Gly His Ser Ile Arg Cys
     770                 775                 780                
 Lys Ser Lys Asn Leu Glu Asp Asp Thr Leu Ser Glu Cys Lys Gln Val
 785                 790                 795                 800
 Ser Asp Lys Ala Val Ser Leu Gln Arg Lys Leu Arg Lys Glu Gln Ser
                 805                 810                 815    
 Leu His Tyr Gly Ser Val Leu Leu Ile Thr Glu Leu Pro Glu Asp Gly
             820                 825                 830        
 Cys Thr Glu Glu Asp Val Arg Lys Leu Phe Gln Pro Phe Gly Lys Val
         835                 840                 845            
 Asn Asp Val Leu Ile Val Pro Tyr Arg Lys Glu Ala Tyr Leu Glu Met
     850                 855                 860                
 Glu Phe Lys Glu Ala Ile Thr Ala Ile Met Lys Tyr Ile Glu Thr Thr
 865                 870                 875                 880
 Pro Leu Thr Ile Lys Gly Lys Ser Val Lys Ile Cys Val Pro Gly Lys
                 885                 890                 895    
 Lys Lys Ala Gln Asn Lys Glu Val Lys Lys Lys Thr Leu Glu Ser Lys
             900                 905                 910        
 Lys Val Ser Ala Ser Thr Leu Lys Arg Asp Ala Asp Ala Ser Lys Ala
         915                 920                 925            
 Val Glu Ile Val Thr Ser Thr Ser Ala Val Pro Ser
     930                 935                 940



      <210> 1580
      <211> 573
      <212> PRT
      <213> Homo sapiens


      <400> 1580
 Met Ala Ser Gln Ala Arg Ser Ser Leu Val Glu Gly Thr Met Asn Trp
   1               5                  10                  15    
 His Leu Pro Leu Phe Leu Leu Ala Ser Val Thr Leu Pro Ser Ile Cys
              20                  25                  30        
 Ser His Phe Asn Pro Leu Ser Leu Glu Glu Leu Gly Ser Asn Thr Gly
          35                  40                  45            
 Ile Gln Val Phe Asn Gln Ile Val Lys Ser Arg Pro His Asp Asn Ile
      50                  55                  60                
 Val Ile Ser Pro His Gly Ile Ala Ser Val Leu Gly Met Leu Gln Leu
  65                  70                  75                  80
 Gly Ala Asp Gly Arg Thr Lys Lys Gln Leu Ala Met Val Met Arg Tyr
                  85                  90                  95    
 Gly Val Asn Gly Val Gly Lys Ile Leu Lys Lys Ile Asn Lys Ala Ile
             100                 105                 110        
 Val Ser Lys Lys Asn Lys Asp Ile Val Thr Val Ala Asn Ala Val Phe
         115                 120                 125            
 Val Lys Asn Ala Ser Glu Ile Glu Val Pro Phe Val Thr Arg Asn Lys
     130                 135                 140                
 Asp Val Phe Gln Cys Glu Val Arg Asn Val Asn Phe Glu Asp Pro Ala
 145                 150                 155                 160
 Ser Ala Cys Asp Ser Ile Asn Ala Trp Val Lys Asn Glu Thr Arg Asp
                 165                 170                 175    
 Met Ile Asp Asn Leu Leu Ser Pro Asp Leu Ile Asp Gly Val Leu Thr
             180                 185                 190        
 Arg Leu Val Leu Val Asn Ala Val Tyr Phe Lys Gly Leu Trp Lys Ser
         195                 200                 205            
 Arg Phe Gln Pro Glu Asn Thr Lys Lys Arg Thr Phe Val Ala Ala Asp
     210                 215                 220                
 Gly Lys Ser Tyr Gln Val Pro Met Leu Ala Gln Leu Ser Val Phe Arg
 225                 230                 235                 240
 Cys Asp Cys Pro Ser Phe Ser Ala Cys Phe Leu Thr Leu Thr Cys Arg
                 245                 250                 255    
 Ser Gly Pro Ala Arg Ala Ala Val Ser Lys Leu Thr Gly Pro Arg Ala
             260                 265                 270        
 Phe Thr Asp Lys Glu Thr Lys Thr Trp Ser Gln Gly Thr Cys Gln Ser
         275                 280                 285            
 Leu Arg Ala Ser Val Leu Gln Val Gln Asp Leu Asn Thr Gly Leu Ile
     290                 295                 300                
 Thr Pro Asp Leu Val Ala Leu Ala Arg Val Leu Tyr Lys Arg Met Gln
 305                 310                 315                 320
 Tyr Leu Ser Asp Gln Val Glu Arg Gln Lys Arg Cys Tyr Phe Ile Ser
                 325                 330                 335    
 Gln Leu Leu Lys Ala Pro Asn Lys Gly Ser Thr Ser Ala Pro Asn Asp
             340                 345                 350        
 Leu Trp Tyr Asn Phe Ile Glu Leu Pro Tyr His Gly Glu Ser Ile Ser
         355                 360                 365            
 Met Leu Ile Ala Leu Pro Thr Glu Ser Ser Thr Pro Leu Ser Ala Ile
     370                 375                 380                
 Ile Pro His Ile Ser Thr Lys Thr Ile Asp Ser Trp Met Ser Ile Met
 385                 390                 395                 400
 Val Pro Lys Arg Val Gln Val Ile Leu Pro Lys Phe Thr Ala Val Ala
                 405                 410                 415    
 Gln Thr Asp Leu Lys Glu Pro Leu Lys Val Leu Gly Ile Thr Asp Met
             420                 425                 430        
 Phe Asp Ser Ser Lys Ala Asn Phe Ala Lys Ile Thr Arg Ser Glu Asn
         435                 440                 445            
 Leu His Val Ser His Ile Leu Gln Lys Ala Lys Ile Glu Val Ser Glu
     450                 455                 460                
 Asp Gly Thr Lys Ala Ser Ala Ala Thr Ser Leu Leu Asn Gly Asn Lys
 465                 470                 475                 480
 Pro Gly Arg Arg Gly Met Ala Lys Thr His Glu Ala Lys Glu Val Cys
                 485                 490                 495    
 Phe Pro Ser Gln Met Pro Thr Pro Ala Ala Ile Leu Ile Ala Arg Ser
             500                 505                 510        
 Ser Pro Pro Trp Phe Ile Val Asp Arg Pro Phe Leu Phe Phe Ile Arg
         515                 520                 525            
 His Asn Pro Thr Gly His Glu Met Gly Thr Ser Asp Ser Ala Leu Val
     530                 535                 540                
 Thr Val Glu Glu Glu Ser Arg Tyr Arg Pro Lys Tyr Thr Glu Ser Ser
 545                 550                 555                 560
 Asp Leu Ala Gly Leu Ser Leu Cys Pro Lys Lys Glu Arg
                 565                 570            



      <210> 1581
      <211> 200
      <212> PRT
      <213> Homo sapiens


      <400> 1581
 Met Leu Leu Pro Leu Trp Phe Phe Leu Val Leu Val Gln Leu Tyr Ala
   1               5                  10                  15    
 Asp Trp Leu Ser Gly Ser Pro Ala Asp Pro Ala Leu Ile Leu Pro Pro
              20                  25                  30        
 Ile Ser Phe Asn Thr Leu Thr Gln Ala Gln Thr Trp Asp Ser Ser Ser
          35                  40                  45            
 Tyr Ser Val Pro Ser Glu Gly Asp Ser Asp Asn Val Phe Leu Arg Pro
      50                  55                  60                
 Gln Arg Asn Leu Glu Ser Ile Asp Pro Gln Phe Thr Ile Arg Arg Lys
  65                  70                  75                  80
 Met Glu Gln Met Arg Glu Glu Lys Glu Leu Val Glu Gln Leu Arg Glu
                  85                  90                  95    
 Ser Ile Glu Met Arg Leu Lys Val Ser Leu His Glu Asp Leu Gly Ala
             100                 105                 110        
 Ala Leu Met Asp Gly Val Val Leu Cys His Leu Val Asn His Ile Arg
         115                 120                 125            
 Pro Arg Ser Val Ala Ser Ile His Val Pro Ser Pro Ala Val Ile Leu
     130                 135                 140                
 Ile Ser Ala Val Glu Glu Ile Glu Pro Ala Leu Arg Ala Leu Phe Leu
 145                 150                 155                 160
 Gly Ile Thr Ala Cys Cys Glu Leu Glu Glu Ser Gln Arg Val Ser Phe
                 165                 170                 175    
 Met Val Val Gln Met Lys Val Glu Glu Ser Gln Ile Asn Leu Ser Leu
             180                 185                 190        
 Lys Pro Thr Gln Asp Leu Tyr Lys
         195                 200



      <210> 1582
      <211> 739
      <212> PRT
      <213> Homo sapiens


      <400> 1582
 Met Arg Leu Leu Val Ala Pro Leu Leu Leu Ala Trp Val Ala Gly Ala
   1               5                  10                  15    
 Thr Ala Ala Val Pro Val Val Pro Trp His Val Pro Cys Pro Pro Gln
              20                  25                  30        
 Cys Ala Cys Gln Ile Arg Pro Trp Tyr Thr Pro Arg Ser Ser Tyr Arg
          35                  40                  45            
 Glu Ala Thr Thr Val Asp Cys Asn Asp Leu Phe Leu Thr Ala Val Pro
      50                  55                  60                
 Pro Ala Leu Pro Ala Gly Thr Gln Thr Leu Leu Leu Gln Ser Asn Ser
  65                  70                  75                  80
 Ile Val Arg Val Asp Gln Ser Glu Leu Gly Tyr Leu Ala Asn Leu Thr
                  85                  90                  95    
 Glu Leu Asp Leu Ser Gln Asn Ser Phe Ser Asp Ala Arg Asp Cys Asp
             100                 105                 110        
 Phe His Ala Leu Pro Gln Leu Leu Ser Leu His Leu Glu Glu Asn Gln
         115                 120                 125            
 Leu Thr Arg Leu Glu Asp His Ser Phe Ala Gly Leu Ala Ser Leu Gln
     130                 135                 140                
 Glu Leu Tyr Leu Asn His Asn Gln Leu Tyr Arg Ile Ala Pro Arg Ala
 145                 150                 155                 160
 Phe Ser Gly Leu Ser Asn Leu Leu Arg Leu His Leu Asn Ser Asn Leu
                 165                 170                 175    
 Leu Arg Ala Ile Asp Ser Arg Trp Phe Glu Met Leu Pro Asn Leu Glu
             180                 185                 190        
 Ile Leu Met Ile Gly Gly Asn Lys Val Asp Ala Ile Leu Asp Met Asn
         195                 200                 205            
 Phe Arg Pro Leu Ala Asn Leu Arg Ser Leu Val Leu Ala Gly Met Asn
     210                 215                 220                
 Leu Arg Glu Ile Ser Asp Tyr Ala Leu Glu Gly Leu Gln Ser Leu Glu
 225                 230                 235                 240
 Ser Leu Ser Phe Tyr Asp Asn Gln Leu Ala Arg Val Pro Arg Arg Ala
                 245                 250                 255    
 Leu Glu Gln Val Pro Gly Leu Lys Phe Leu Asp Leu Asn Lys Asn Pro
             260                 265                 270        
 Leu Gln Arg Val Gly Pro Gly Asp Phe Ala Asn Met Leu His Leu Lys
         275                 280                 285            
 Glu Leu Gly Leu Asn Asn Met Glu Glu Leu Val Ser Ile Asp Lys Phe
     290                 295                 300                
 Ala Leu Val Asn Leu Pro Glu Leu Thr Lys Leu Asp Ile Thr Asn Asn
 305                 310                 315                 320
 Pro Arg Leu Ser Phe Ile His Pro Arg Ala Phe His His Leu Pro Gln
                 325                 330                 335    
 Met Glu Thr Leu Met Leu Asn Asn Asn Ala Leu Ser Ala Leu His Gln
             340                 345                 350        
 Gln Thr Val Glu Ser Leu Pro Asn Leu Gln Glu Val Gly Leu His Gly
         355                 360                 365            
 Asn Pro Ile Arg Cys Asp Cys Val Ile Arg Trp Ala Asn Ala Thr Gly
     370                 375                 380                
 Thr Arg Val Arg Phe Ile Glu Pro Gln Ser Thr Leu Cys Ala Glu Pro
 385                 390                 395                 400
 Pro Asp Leu Gln Arg Leu Pro Val Arg Glu Val Pro Phe Arg Glu Met
                 405                 410                 415    
 Thr Asp His Cys Leu Pro Leu Ile Ser Pro Arg Ser Phe Pro Pro Ser
             420                 425                 430        
 Leu Gln Val Ala Ser Gly Glu Ser Met Val Leu His Cys Arg Ala Leu
         435                 440                 445            
 Ala Glu Pro Glu Pro Glu Ile Tyr Trp Val Thr Pro Ala Gly Leu Arg
     450                 455                 460                
 Leu Thr Pro Ala His Ala Gly Arg Arg Tyr Arg Val Tyr Pro Glu Gly
 465                 470                 475                 480
 Thr Leu Glu Leu Arg Arg Val Thr Ala Glu Glu Ala Gly Leu Tyr Thr
                 485                 490                 495    
 Cys Val Ala Gln Asn Leu Val Gly Ala Asp Thr Lys Thr Val Ser Val
             500                 505                 510        
 Val Val Gly Arg Ala Leu Leu Gln Pro Gly Arg Asp Glu Gly Gln Gly
         515                 520                 525            
 Leu Glu Leu Arg Val Gln Glu Thr His Pro Tyr His Ile Leu Leu Ser
     530                 535                 540                
 Trp Val Thr Pro Pro Asn Thr Val Ser Thr Asn Leu Thr Trp Ser Ser
 545                 550                 555                 560
 Ala Ser Ser Leu Arg Gly Gln Gly Ala Thr Ala Leu Ala Arg Leu Pro
                 565                 570                 575    
 Arg Gly Thr His Ser Tyr Asn Ile Thr Arg Leu Leu Gln Ala Thr Glu
             580                 585                 590        
 Tyr Trp Ala Cys Leu Gln Val Ala Phe Ala Asp Ala His Thr Gln Leu
         595                 600                 605            
 Ala Cys Leu Pro Trp Gly Ser Glu Leu Leu Lys Ser Leu Asn Val Asn
     610                 615                 620                
 Ala Phe Phe Ser Glu Glu Asn Val Ser Tyr Gly Asp Leu Ile Cys Val
 625                 630                 635                 640
 Ser Pro Glu Ser Pro Gly Pro Gly Leu Leu Gly Tyr Ser Arg Glu Val
                 645                 650                 655    
 Ser Tyr Arg Thr Thr Phe Tyr Ile Lys Asn Lys His Val Asp Gly Val
             660                 665                 670        
 Tyr Ser Ser Gln Gly Cys Val Thr Leu Asn Arg Asn Asn Gln Gly Leu
         675                 680                 685            
 Thr Thr Glu Asp Lys Glu Glu Met Ala Ser Leu Thr Pro Leu Gly Ile
     690                 695                 700                
 Ile Gly Ala Ala Gly Tyr Ser Pro Asp Glu Thr Val Asn His Lys Ser
 705                 710                 715                 720
 Leu Val Phe Ile Leu Leu Ser Pro Gly Gln Arg Val Arg Ala Phe Val
                 725                 730                 735    
 Pro Gly Leu
            



      <210> 1583
      <211> 199
      <212> PRT
      <213> Homo sapiens


      <400> 1583
 Met Tyr Ser Met Val Tyr Met Cys His Ile Phe Leu Ile Gln Ser Ile
   1               5                  10                  15    
 Ile Asp Gly His Met Ser Leu Gly Cys Phe Ser Glu Thr Trp Thr Pro
              20                  25                  30        
 Pro Asn Gly Ser Val Gly Met Tyr Thr Ser Ala Ile Gln Met Ser Val
          35                  40                  45            
 Phe Ser Phe Ala Ala Leu Gly Gly Gln Thr Glu Val Gln Phe Gly Ala
      50                  55                  60                
 Thr Ile Leu Phe Thr Ser Asn Tyr Thr Phe Arg Cys Thr Lys Ser Ala
  65                  70                  75                  80
 Lys Gly Phe Gln Phe Leu His Ile Leu Thr Asn Thr Cys Tyr Phe Leu
                  85                  90                  95    
 Phe Leu Glu Arg Ser His Tyr Ser Arg Tyr Gly Gly Gly Ile Thr Val
             100                 105                 110        
 Leu Arg Glu Glu Lys Gly Arg Asn Arg Phe Asn Gly His Glu His Glu
         115                 120                 125            
 Pro Leu Arg Pro Glu Asp His Val Phe His Cys Glu Pro Lys Ala Asp
     130                 135                 140                
 Lys His Tyr His Leu Lys Val Asp Asn Asp Glu Asn Glu His Gln Leu
 145                 150                 155                 160
 Ser Leu Arg Met Val Ser Leu Glu Ala Gly Ala Asn Asp Glu Leu Gln
                 165                 170                 175    
 Ile Val Asp Thr Glu Thr Met Asn Tyr Glu Gly Ser Pro Ile Lys Ile
             180                 185                 190        
 Ile Leu Ala Thr Gly Arg Ala
         195                



      <210> 1584
      <211> 330
      <212> PRT
      <213> Homo sapiens


      <400> 1584
 Met Glu Ala Trp Gly Gly His Arg Val Ala Val Ser Gly Gln Tyr Leu
   1               5                  10                  15    
 Trp Arg Leu Pro Val Leu Val Val Met Glu Thr Ser Gln Gln Ser Cys
              20                  25                  30        
 Arg Lys Pro Ala Asp Trp Glu Pro Asp His Val Thr Arg Glu Lys Leu
          35                  40                  45            
 Asp Arg Ile Leu Ala Val Ile Gln Gly Ser His Gln Lys Ala Leu Val
      50                  55                  60                
 Met Tyr Ser Asn Leu Asp Leu Lys Thr Gln Glu Ala Tyr Glu Met Ala
  65                  70                  75                  80
 Val Arg Gly Leu Ile Arg Pro Met Asn Lys Ser Pro Met Leu Ile Thr
                  85                  90                  95    
 Gly Ile Arg Cys Leu Tyr Phe Ala Pro Pro Glu Phe Leu Leu Glu Val
             100                 105                 110        
 Gln Cys Met His Glu Thr Gln Lys Glu Leu Arg Lys Leu Val His Glu
         115                 120                 125            
 Ile Gly Leu Glu Leu Lys Thr Thr Ala Val Cys Thr Gln Val Arg Arg
     130                 135                 140                
 Thr Arg Asp Gly Phe Phe Thr Leu Asp Ser Ala Leu Leu Arg Thr Gln
 145                 150                 155                 160
 Trp Asp Leu Thr Asn Ile Gln Asp Ala Ile Arg Ala Ala Thr Pro Gln
                 165                 170                 175    
 Ser Leu Glu Gln Cys Leu Lys Lys Tyr Cys Gly Arg Asn Ala Asn Ala
             180                 185                 190        
 Tyr Leu Thr Ala Ala Phe Lys Val Pro Asp Asp Lys Tyr Phe Arg Val
         195                 200                 205            
 Gly Phe Ile Pro Asp Met Ile Lys Gln Thr Ile Glu Ala Thr Ser Thr
     210                 215                 220                
 His Pro Arg Pro Lys Gly Thr Gly Ala Glu Pro Arg Ser Ser Arg Gln
 225                 230                 235                 240
 Met Leu Ser Val Cys Glu Met Gln Val Glu Arg Met Ser Ser Asp Val
                 245                 250                 255    
 Asn Leu Thr Lys Ser Cys Ser Gln Gly Ala Ser Gly Leu Ala Val Pro
             260                 265                 270        
 His Gly Pro His Leu Ala Thr Leu Glu Leu Cys His Val Pro Ala Thr
         275                 280                 285            
 Val Phe Asn Asn Gly Pro Thr Arg Thr Pro Trp Thr Leu Thr Pro Phe
     290                 295                 300                
 Cys Arg Gly Met Lys Gln Ser Phe Leu Asp Ser Ile Leu His Thr Glu
 305                 310                 315                 320
 Leu Leu Asp Ser Ser Ala Ser Asn Pro Pro
                 325                 330



      <210> 1585
      <211> 720
      <212> PRT
      <213> Homo sapiens


      <400> 1585
 Met Ala Cys Phe Leu Leu Pro Cys Val Cys Gly Leu Phe Pro Pro Ser
   1               5                  10                  15    
 Val Arg Leu Trp Arg Phe Leu Arg Pro Cys Val Cys Gly Leu Phe Pro
              20                  25                  30        
 Pro Ser Val Arg Leu Trp Arg Phe Leu Arg Arg Cys Val Cys Asp Val
          35                  40                  45            
 Ser Ser Val Arg Ala Ser Val Thr Phe Pro Pro Ser Val Arg Leu Trp
      50                  55                  60                
 Arg Phe Leu Arg Arg Cys Val Cys Asp Val Ser Ser Val Arg Ala Ser
  65                  70                  75                  80
 Val Thr Phe Pro Pro Ser Val Arg Leu Trp Pro Val Ser Ser Val Arg
                  85                  90                  95    
 Ala Ser Val Ala Cys Phe Leu Arg Pro Cys Val Cys Gly Val Ser Ser
             100                 105                 110        
 Val Arg Ala Pro Val Val Cys Phe Leu Arg Pro Cys Val Cys Asp Val
         115                 120                 125            
 Ser Ser Val Arg Ala Ser Val Thr Phe Pro Pro Ser Val Arg Leu Trp
     130                 135                 140                
 Pro Val Ser Ser Val Arg Ala Ser Val Ala Phe Pro Pro Ser Val Arg
 145                 150                 155                 160
 Leu Trp Arg Phe Leu Arg Leu Trp Ile Cys Gly Val Ser Ser Val Ser
                 165                 170                 175    
 Val Pro Glu Pro Trp Tyr Leu Ser Gln Phe Trp Asn Leu Leu Cys Pro
             180                 185                 190        
 Cys Cys Leu Pro Phe Thr Asp Ser Arg Leu Ser Ser Cys His Ser Phe
         195                 200                 205            
 Asn Thr Glu Ser Ser Ser Val His Thr Ala Trp Gln Cys Cys Ala Pro
     210                 215                 220                
 Val Leu Leu Ala Ser Cys Phe Phe Asn Val Leu Ala Glu Asn Gln Ala
 225                 230                 235                 240
 Asp Thr Arg Val Pro Phe Ser Leu Gly Thr Asp Gln Val Gly Glu Glu
                 245                 250                 255    
 Gly Arg Cys Gly Thr Glu Val His Lys Arg Glu Phe Asn Asp Ala Leu
             260                 265                 270        
 Arg Asp Arg Cys Ile Trp Gly Thr Phe Cys Arg Thr Leu Ala Pro Asp
         275                 280                 285            
 Ser Arg Lys Val Ile Thr Asp Lys Gly Cys Glu Ala Val Pro Asp Glu
     290                 295                 300                
 Asp Gly Glu Gly Glu Ser Leu Gly Ala Val Cys Gly Pro Asp Arg Lys
 305                 310                 315                 320
 Asp Val Phe Gly Arg Ile Val Leu Ile Glu Tyr Lys Val Asp Ser Asp
                 325                 330                 335    
 Ala Leu Lys Trp Phe Leu Ser Ala Asp Asp Gly Ser Ala Ala Ala Glu
             340                 345                 350        
 Gly Pro Leu Phe Leu Gly Asn Ala Tyr Gly Ala Gly Arg Gly Val Trp
         355                 360                 365            
 Val His Thr Gly Ala Arg Met Val Ser Ser Tyr Gly Ala Gly Arg Gly
     370                 375                 380                
 Val Trp Val His Thr Gly Ala Arg Val Val Ser Ser Tyr Gly Ala Gly
 385                 390                 395                 400
 Arg Gly Val Trp Val His Thr Gly Ala Arg Val Val Ser Ser Tyr Gly
                 405                 410                 415    
 Ala Gly Arg Arg Val Trp Val His Thr Gly Ala Arg Val Val Ser Ser
             420                 425                 430        
 Tyr Gly Ala Gly Arg Gly Val Trp Val His Thr Gly Ala Arg Val Val
         435                 440                 445            
 Ser Ser Tyr Gly Ala Gly Arg Gly Val Trp Val His Thr Gly Ala Arg
     450                 455                 460                
 Val Val Ser Ser Tyr Val Thr Val Leu Ala Val Glu Ser Gly Phe Thr
 465                 470                 475                 480
 Pro Val Pro Ala Trp Ser Pro Val Thr Val Leu Ala Val Glu Ser Gly
                 485                 490                 495    
 Phe Thr Pro Val Pro Ala Trp Ser Pro Val Thr Val Leu Ala Val Gly
             500                 505                 510        
 Ser Glu Phe Thr Pro Val Pro Ala Trp Ser Pro Val Thr Val Leu Ala
         515                 520                 525            
 Val Glu Ser Gly Phe Thr Pro Val Pro Ala Trp Ser Pro Val Thr Val
     530                 535                 540                
 Leu Ala Val Gly Ser Glu Phe Thr Leu Gly Trp Gly Arg Gly Asp Gly
 545                 550                 555                 560
 Gly Gly Gly Ala Arg Pro Pro Thr Arg Phe Pro Leu Glu Leu Ser Gln
                 565                 570                 575    
 Asn Ser Pro Leu Arg Ser Pro Gln Leu Pro Glu Ser Gln Glu Leu Leu
             580                 585                 590        
 Arg Arg Ser His Cys Leu His Ala Thr Cys Phe Asp Asp Pro Ala Leu
         595                 600                 605            
 Pro Ser Leu Cys Ser Lys Gly Arg Ala Leu Pro Leu Pro Val Pro Asp
     610                 615                 620                
 Gly Ser Gln Gly Asp Ala Gly Gln Gln Val Val Arg Val Gly Ser Glu
 625                 630                 635                 640
 Cys Gly Asp Glu Leu Ile Arg Leu Tyr Ser Phe Thr Asp Glu Lys Ala
                 645                 650                 655    
 Asn Tyr Leu Gln Gln Gly Asn Asn His Arg Pro Ile His Lys Asp His
             660                 665                 670        
 Phe Trp Leu Ile Tyr Gly Thr Leu Phe Tyr Leu Val Asn Phe Gly Arg
         675                 680                 685            
 Tyr Leu Ser Leu Arg Gly Lys Gln Arg Thr Gln Leu Lys Ile Gln Phe
     690                 695                 700                
 Ser Cys Thr Ala Glu Arg Leu Val Thr Gln Val Gln Met Leu Gly Cys
 705                 710                 715                 720





      <210> 1586
      <211> 535
      <212> PRT
      <213> Homo sapiens


      <400> 1586
 Met Arg Asn Leu Val Asn Val Ile Tyr Ile Val Val Val Leu Ser Ser
   1               5                  10                  15    
 Ser Asp Arg Leu Pro Phe Gly Ile Glu Glu Asn Gly Gly Thr Pro Phe
              20                  25                  30        
 Leu Thr Ala Ala Ser Gly Arg His His His Gln His Gln His Gln His
          35                  40                  45            
 Gln His Gln His His Ser Asn Tyr Ser Leu Ser Leu Thr Leu Glu Asn
      50                  55                  60                
 Lys Glu Gly Pro Leu Arg Ser Pro Asn Ser Ser Ser Lys Ser Leu Thr
  65                  70                  75                  80
 Lys Leu Ser Pro Gly Thr Pro Ala Leu Phe Ser Glu Ala Ala Ala His
                  85                  90                  95    
 Leu Lys Lys Leu Glu Leu Glu Thr Val Lys Ala Ala Gly Pro Trp Pro
             100                 105                 110        
 Pro Leu His Ile Asn Ile Asn Lys Ala Glu Glu Lys Lys Val Ser Glu
         115                 120                 125            
 Lys Thr Leu Gln Thr Pro Leu Leu Pro Ser Pro Val Ala Asp His Val
     130                 135                 140                
 Lys Cys Asn Ile Leu Lys Ala Gln Leu Glu Asn Ala Ser Arg Val Asn
 145                 150                 155                 160
 Ile Gln Leu Asp Leu Pro Val Leu Glu Asn Cys Lys Leu Tyr Ser Ala
                 165                 170                 175    
 Val Thr Ala Gly Gly Pro Ala Ala Ala His Lys Lys Gln Gln Gly Trp
             180                 185                 190        
 Gly Asp Ser Gln Glu Gln Glu Ala Asp Lys Glu Arg Pro Met Trp Thr
         195                 200                 205            
 Glu Pro Ile Met Glu Pro Pro Gly Lys Ala Asp Met Arg Ser Pro Ile
     210                 215                 220                
 Pro Ile Arg Val Glu Thr Ala Gln Pro Ala Val Glu Lys Pro Glu Ile
 225                 230                 235                 240
 Lys Pro Pro Arg Val Arg Lys Leu Thr Arg Gln Tyr Ser Phe Asn Arg
                 245                 250                 255    
 Ser Asp Glu Asp Asp Leu Pro Pro Asp Leu Ala Glu Ala Val Gly Val
             260                 265                 270        
 Thr Thr Ser Thr Thr Thr Asn Thr Thr Thr Ala Ala Thr Gln Val Ser
         275                 280                 285            
 Val Pro Leu Pro Ser Pro Lys Val Gln Asn Val Ser Ser Pro His Lys
     290                 295                 300                
 Ser Glu Gly Lys Gly Leu Leu Ser Pro Gly Ala Lys Ser Pro Ser Asp
 305                 310                 315                 320
 Arg Gly Gly Ala Phe Thr Leu Glu Pro Gly Asp Leu Leu Met Asp Phe
                 325                 330                 335    
 Thr Glu Ala Thr Pro Leu His Gln Lys Cys Lys Gln Gln Pro Ser Tyr
             340                 345                 350        
 Leu Leu Ala Glu Pro Ala Ser Asn Pro His Cys Ala His Ser Arg Cys
         355                 360                 365            
 Ser Pro Pro Leu Ser Leu Pro Met Lys Glu Glu Thr Thr Gly Val Cys
     370                 375                 380                
 Met Tyr Pro Pro Ile Lys Thr Arg Leu Ile Lys Thr Phe Pro Val Asp
 385                 390                 395                 400
 Thr Met Asn Pro Phe Pro Asp Thr Phe Thr Thr Gly Pro Gln Phe Thr
                 405                 410                 415    
 Ala Asp Phe Arg Asp Ser Lys Leu Gln Cys Cys Pro Gly Pro Thr Ser
             420                 425                 430        
 Pro Leu Ile Pro Ala Ala Thr Leu Arg Pro Leu Thr Glu Thr Val Ser
         435                 440                 445            
 Thr Val Gln Thr Ile Tyr Thr Thr Arg Lys Pro Val Ser Leu Ala Ala
     450                 455                 460                
 Arg Asp Thr Pro Ala Gly Thr Gly Glu Arg Glu Asp Asp Glu Lys Thr
 465                 470                 475                 480
 Val Asp Asp Arg Thr Val Lys Phe Ser Pro Cys His Leu Glu Asp Gly
                 485                 490                 495    
 Met Ser Ser Gln Met Leu Lys Phe Leu Lys Val Asp Val Thr Gly Ser
             500                 505                 510        
 Leu Thr Thr Asn Lys Leu Ala Val Thr Val Phe Glu Thr Gln Tyr Leu
         515                 520                 525            
 Trp Gln Leu Thr Ser Asn Gln
     530                 535



      <210> 1587
      <211> 351
      <212> PRT
      <213> Homo sapiens


      <400> 1587
 Met Thr Val Leu Phe Tyr Leu Ala Asp Leu Cys Ser Phe Ile Tyr Pro
   1               5                  10                  15    
 Ile Pro Phe Ala Pro Ile Tyr Lys Tyr Gly Tyr Lys Tyr Ile Lys Lys
              20                  25                  30        
 Thr Gly Ile Asn Trp Thr Asp Asp Glu Lys Arg Ser Tyr Lys Asp Lys
          35                  40                  45            
 Gly Ile Val Gln Thr Gln Glu Ile Leu Gln Tyr Leu Leu Pro Ile Val
      50                  55                  60                
 His Ser Thr Lys Asn Met Gln Thr Thr Gln Ile Lys Gln Leu Phe Asn
  65                  70                  75                  80
 Pro Arg Thr Asn Phe Gln Ile Gln His His Thr Val Tyr Asn Ser Lys
                  85                  90                  95    
 Asp Met Glu Pro Thr Gln Ile Pro Ile Ser Asp Arg Leu Asp Lys Glu
             100                 105                 110        
 Asn Val Ala Ile Tyr Thr Met Glu Tyr Tyr Ala Ala Ile Lys Arg Asn
         115                 120                 125            
 Gly Ile Cys Gln Ala Arg Trp Leu Thr Pro Ile Ile Pro Ala Leu Trp
     130                 135                 140                
 Glu Ala Lys Glu Ile Leu Asp Phe Asp Gln Ala Gln Gln Ile Lys Cys
 145                 150                 155                 160
 Phe Asn Ser Asn Leu Phe Leu Cys Asn Ile Cys Phe Cys Lys Lys Leu
                 165                 170                 175    
 Gly Ser Glu Cys Met Tyr Phe Leu Glu Cys Arg His Val Tyr Cys Lys
             180                 185                 190        
 Asp Cys Leu Lys Asp Tyr Phe Glu Ile Gln Ile Arg Asp Gly Gln Val
         195                 200                 205            
 Gln Cys Leu Asn Cys Pro Glu Pro Lys Cys Pro Ser Val Ala Thr Thr
     210                 215                 220                
 Gly Gln Val Lys Glu Leu Val Glu Ala Glu Leu Phe Ala Tyr Tyr Asp
 225                 230                 235                 240
 Cys Leu Leu Leu Gln Ser Thr Leu Asp Leu Met Ala Asp Val Val Tyr
                 245                 250                 255    
 Cys Pro His Ala Cys Cys Gln Leu Pro Val Met Gln Glu Pro Gly Tyr
             260                 265                 270        
 Ile Met Gly Ile Cys Ser Ser Cys Asn Phe Ala Phe Cys Thr Leu Cys
         275                 280                 285            
 Arg Leu Thr Tyr His Gly Val Ser Pro Cys Lys Val Thr Ala Glu Lys
     290                 295                 300                
 Leu Ile Asp Leu Leu Asn Glu Tyr Leu Gln Ala Asp Lys Ala Asn Lys
 305                 310                 315                 320
 Arg Leu Leu Glu Gln Arg Tyr Asp Lys Arg Val Ile Gln Lys Ala Leu
                 325                 330                 335    
 Glu Glu Met Glu Ser Lys Glu Trp Leu Glu Lys Asn Phe Lys Asn
             340                 345                 350    



      <210> 1588
      <211> 250
      <212> PRT
      <213> Homo sapiens


      <400> 1588
 Met Val Phe Ser Ile Leu Gln Val Ala Gln Ala Lys Thr Leu Ala Leu
   1               5                  10                  15    
 Val Phe Asp Ala Tyr Leu Phe Ser His Thr Pro Gln Leu Ile His Gln
              20                  25                  30        
 His Ile Arg Arg Ile Lys Arg Phe Thr Trp Phe Ala Leu His Lys Leu
          35                  40                  45            
 Tyr Lys Glu Val Cys Ala Cys Thr His Thr Ser Ile Ala Phe Ser Glu
      50                  55                  60                
 Asp Asn Lys Lys Phe Asp Gly Tyr Ala Thr His Cys Thr Leu Arg Asp
  65                  70                  75                  80
 Ile Ile Ala Tyr Lys Arg Asn Pro Ile Lys Ser Cys Leu Glu Val Gly
                  85                  90                  95    
 Thr Glu Gly Lys Val Glu Leu Ser Arg Glu Val Val Leu Arg Val Lys
             100                 105                 110        
 Ile Arg Gly Arg Gln Leu Pro Tyr Lys Gly His Cys Leu Lys Thr Ser
         115                 120                 125            
 Lys His His Met Asp Leu Ile Val Val Tyr Phe Gly Lys Lys Glu Asp
     130                 135                 140                
 Thr Val Glu Gln Leu Arg His Tyr Ile Leu Gln Phe His Tyr Phe His
 145                 150                 155                 160
 Pro Ser Gln Phe Tyr Tyr Cys Val Ile Lys Gly Asn Leu Thr Glu Asp
                 165                 170                 175    
 Thr Asp Ala His Ser Thr Gln Val Thr Val Pro Gly Gln Ile Ala Asp
             180                 185                 190        
 Ala Glu Lys Ala Phe Asp Lys Ile Gln Gln Pro Phe Met Leu Lys Thr
         195                 200                 205            
 Leu Asp Lys Leu Gly Ile Asp Gly Met Tyr Ile Lys Ile Ile Arg Ala
     210                 215                 220                
 Ile Tyr Asp Lys Pro Thr Ala Asn Ile Ile Leu Asn Gly Gln Lys Leu
 225                 230                 235                 240
 Glu Ala Phe Pro Leu Lys Thr Gly Thr Arg
                 245                 250



      <210> 1589
      <211> 224
      <212> PRT
      <213> Homo sapiens


      <400> 1589
 Met Ile Met Val Gly Phe Leu Gly Asn Phe Phe Leu Leu Tyr His Tyr
   1               5                  10                  15    
 Ser Phe Leu Cys Phe Thr Arg Asp Asp Ile Ile Leu Tyr Leu Asp Asn
              20                  25                  30        
 Ser Met Val Ser Ala Gln Lys Leu Leu Gln Leu Ile Asp Asn Phe Ser
          35                  40                  45            
 Lys Val Ser Glu Tyr Lys Ile Asn Ile Gln Lys Ser Leu Ala Phe Leu
      50                  55                  60                
 Tyr Thr Asn Asn Ser Gln Ala Glu Ser Gln Ile Arg Lys Ala Ile Pro
  65                  70                  75                  80
 Phe Thr Ile Thr Thr Lys Arg Ile Glu Tyr Leu Gly Ile Gln Leu Thr
                  85                  90                  95    
 Arg Lys Val Lys Asp Pro Tyr Arg Gly Val Leu Ser Phe Ser Thr Leu
             100                 105                 110        
 Gly Thr Arg Glu Tyr Gly Trp Asp Glu Pro Ala Leu Ser Ala Lys Asp
         115                 120                 125            
 Ile Gly His Leu Gly Gly His Gly Thr Gly Leu Tyr His Ser Thr Glu
     130                 135                 140                
 Ala Pro Gly Ala Ser Gln Ser Glu Gly Gln Thr Arg Gln Val Val Pro
 145                 150                 155                 160
 His Val Arg Asn Ala Thr Met Asp His Asp Arg Asn Leu Lys Asn Glu
                 165                 170                 175    
 Gly Glu Glu Ile Ala Gln Tyr Leu Arg His Arg Phe Ile Tyr Leu Ser
             180                 185                 190        
 Ile Tyr Leu Ser Ile Tyr Leu Ser Ile Tyr Leu Pro Thr Tyr Leu Pro
         195                 200                 205            
 Thr Tyr Leu Ser Leu Tyr Leu Phe Ile His Pro Ser Ile Gln Met Tyr
     210                 215                 220                





      <210> 1590
      <211> 239
      <212> PRT
      <213> Homo sapiens


      <400> 1590
 Met Thr Gly Leu Asp Trp Gln Tyr Leu Val Met Ile Leu Leu Leu Pro
   1               5                  10                  15    
 Ala Gln Pro Arg Ser Trp Asp Ser Glu Ala Val Gln His Cys Gly Asp
              20                  25                  30        
 Gly Glu Ile Gly Pro Val Asp Val Asp Ser Thr Ile Arg Ala Gly Asp
          35                  40                  45            
 Ser Gly Asp Arg Gln Arg Tyr Leu His Asp Arg Ser Lys Leu Gly Lys
      50                  55                  60                
 Glu Lys Gln Arg Asp Ala Lys Gly Ser Gly Thr Trp Met Lys Leu Glu
  65                  70                  75                  80
 Ile Ile Ile Leu Ser Lys Leu Ser Gln Gly Gln Lys Thr Lys His Gly
                  85                  90                  95    
 Met Phe Ser Leu Ile Ala Ser Thr Thr Ser Lys Ile Ala Ser Ile Ile
             100                 105                 110        
 Thr Lys Ser Ile Ile Ala Ile Pro Thr Ala Thr Ile Thr Thr Thr Thr
         115                 120                 125            
 Met Thr Ala Thr Lys Ala Thr Met Thr Thr Glu Ala Ser Ser Thr Thr
     130                 135                 140                
 Thr Thr Ser Met Thr Met Ile Lys Gly Phe Pro Asn Phe Thr Val Val
 145                 150                 155                 160
 Val Ile His Thr Met Val Phe Leu Asn Asp Ser Leu Ile His Gly Val
                 165                 170                 175    
 Met Val Val Lys Gly Tyr Lys Gly Lys Ile Pro Phe Leu Thr Thr Ala
             180                 185                 190        
 Ser Val Asp Trp Ile Lys Lys Thr Trp His Ile Tyr Thr Met Glu Tyr
         195                 200                 205            
 Tyr Ala Ala Val Lys Lys Asp Glu Phe Met Ser Phe Val Gly Thr Trp
     210                 215                 220                
 Met Lys Leu Glu Thr Ile Ile Leu Ser Lys Leu Ser Lys Gly Leu
 225                 230                 235                



      <210> 1591
      <211> 947
      <212> PRT
      <213> Homo sapiens


      <400> 1591
 Met Gly Pro Leu Met Phe Leu Thr His Phe Arg Gly Ala Ile Cys Ala
   1               5                  10                  15    
 Val Ile Ser Glu Gly Pro Pro Ser Ser Ser Val Thr Ser Val His Tyr
              20                  25                  30        
 Met Gly Asn Ser Ser Asn Thr Lys Ala Pro Gln Phe Asp Leu Leu Ile
          35                  40                  45            
 Ser Asn Asp Leu Pro Leu His Ser Thr Thr Leu Ala Leu Glu Asn Leu
      50                  55                  60                
 Leu Ala Ala Thr Ser Leu Val Thr Pro Val Thr Glu Lys Cys Gly Gly
  65                  70                  75                  80
 Ala His Glu Ser Cys Thr Pro Leu Leu Ser Ser Thr Gln Val Gln Leu
                  85                  90                  95    
 Thr Val Ser Ile Leu Leu Thr Lys Leu Asn Leu Arg Ser Thr Ala Arg
             100                 105                 110        
 His Val Ala Thr Gly His Arg Glu Ile Ile Ala Ser Tyr Gly Pro Val
         115                 120                 125            
 Tyr Glu Ile Pro Leu His Thr His Met Gly Trp Leu Ile Cys Arg Lys
     130                 135                 140                
 Ser Thr Asp Lys Ile Gln His Pro Phe Met Ile Lys Thr Leu Ser Lys
 145                 150                 155                 160
 Ile Gly Thr Glu Gly Thr Tyr Leu Lys Gly Phe Arg Phe Thr Met Asp
                 165                 170                 175    
 Ala Asp Lys Glu Lys Asp Leu Gln Lys Phe Leu Lys Asn Val Asp Glu
             180                 185                 190        
 Ile Ser Asn Leu Ile Gln Glu Met Asn Ser Asp Asp Pro Val Val Gln
         195                 200                 205            
 Gln Lys Ala Val Leu Glu Thr Glu Lys Arg Leu Leu Leu Met Glu Glu
     210                 215                 220                
 Asp Gln Glu Glu Asp Glu Cys Arg Thr Thr Leu Asn Lys Thr Met Ile
 225                 230                 235                 240
 Ser Pro Pro Gln Thr Ala Met Lys Ser Ala Glu Glu Ile Asn Ser Ala
                 245                 250                 255    
 Leu Lys Glu Lys Gly Asn Glu Ala Phe Ala Glu Gly Asn Tyr Glu Thr
             260                 265                 270        
 Ala Ile Leu Arg Tyr Ser Glu Gly Leu Glu Lys Leu Lys Asp Met Lys
         275                 280                 285            
 Val Leu Tyr Thr Asn Arg Ala Gln Ala Tyr Met Lys Leu Glu Asp Tyr
     290                 295                 300                
 Glu Lys Ala Leu Val Asp Cys Glu Trp Ala Leu Lys Cys Asp Glu Lys
 305                 310                 315                 320
 Cys Thr Lys Ala Tyr Phe His Met Gly Lys Ala Asn Leu Ala Leu Lys
                 325                 330                 335    
 Asn Tyr Ser Val Ser Arg Glu Cys Tyr Lys Lys Ile Leu Glu Ile Asn
             340                 345                 350        
 Pro Lys Leu Gln Thr Gln Val Lys Gly Tyr Leu Asn Gln Val Asp Leu
         355                 360                 365            
 Gln Glu Lys Ala Asp Leu Gln Glu Lys Glu Ala His Glu Leu Leu Asp
     370                 375                 380                
 Ser Gly Lys Asn Thr Ala Val Thr Thr Lys Asn Leu Leu Glu Thr Leu
 385                 390                 395                 400
 Ser Lys Pro Asp Gln Ile Pro Leu Phe Tyr Ala Gly Gly Ile Glu Ile
                 405                 410                 415    
 Leu Thr Glu Met Ile Asn Glu Cys Thr Glu Gln Thr Leu Phe Arg Met
             420                 425                 430        
 His Asn Gly Phe Ser Ile Ile Ser Asp Asn Glu Val Ile Arg Arg Cys
         435                 440                 445            
 Phe Ser Thr Ala Gly Asn Asp Ala Val Glu Glu Met Val Cys Val Ser
     450                 455                 460                
 Val Leu Lys Leu Trp Gln Ala Val Cys Ser Arg Asn Glu Glu Asn Gln
 465                 470                 475                 480
 Arg Val Leu Val Ile His His Asp Arg Ala Arg Leu Leu Ala Ala Leu
                 485                 490                 495    
 Leu Ser Ser Lys Val Leu Ala Ile Arg Gln Gln Ser Phe Ala Leu Leu
             500                 505                 510        
 Leu His Leu Ala Gln Thr Glu Ser Gly Arg Ser Leu Ile Ile Asn His
         515                 520                 525            
 Leu Asp Leu Thr Arg Leu Leu Glu Ala Leu Val Ser Phe Leu Asp Phe
     530                 535                 540                
 Ser Asp Lys Glu Ala Asn Thr Ala Met Gly Leu Phe Thr Asp Leu Ala
 545                 550                 555                 560
 Leu Glu Glu Ser Glu Thr Pro Gly Met Pro Leu Cys Asp Met Lys Leu
                 565                 570                 575    
 Ser Gly Trp Phe Val Gly Leu Leu Lys Thr Asp Pro Lys Val Ser Ser
             580                 585                 590        
 Ser Ser Ala Leu Cys Gln Cys Ile Ala Ile Met Gly Asn Leu Ser Ala
         595                 600                 605            
 Glu Pro Thr Thr Arg Arg His Met Ala Ala Cys Glu Glu Phe Gly Asp
     610                 615                 620                
 Gly Cys Leu Ser Leu Leu Val Trp Ala Val Glu Val Ser Arg Arg Cys
 625                 630                 635                 640
 Leu Ser Leu Leu Asn Ser Gln Asp Gly Gly Ile Leu Thr Arg Ala Ala
                 645                 650                 655    
 Gly Val Leu Ser Arg Thr Leu Ser Ser Ser Leu Lys Ile Val Glu Glu
             660                 665                 670        
 Ala Leu Arg Ala Gly Val Val Lys Lys Met Met Lys Phe Leu Lys Gln
         675                 680                 685            
 Ala Ser Gln Glu Arg Gln Pro Ala Asn Val Leu Leu Thr Asn Ser Leu
     690                 695                 700                
 Glu Cys Thr Glu Gly Glu Leu Lys Glu Ala Pro Pro Trp Lys Arg Gln
 705                 710                 715                 720
 Ala Phe Leu Leu Asp Pro Val Ala Tyr Pro Ala Glu Leu Ser Val Met
                 725                 730                 735    
 Met Lys Leu Leu Ser Ser Glu Asp Glu Val Leu Val Gly Asn Ala Ala
             740                 745                 750        
 Leu Cys Leu Gly Asn Cys Met Glu Val Pro Asn Val Ala Ser Ser Leu
         755                 760                 765            
 Leu Lys Thr Asp Leu Leu Gln Val Leu Leu Lys Leu Ala Gly Ser Asp
     770                 775                 780                
 Thr Gln Lys Thr Ala Val Gln Val Asn Ala Gly Ile Ala Leu Gly Lys
 785                 790                 795                 800
 Leu Cys Thr Ala Glu Pro Arg Gly Asn Ala Pro Phe Gln Leu Pro Gln
                 805                 810                 815    
 Gly His Ser Lys Pro Gly Ser Pro Val Asp Cys Lys Ser Leu Lys Cys
             820                 825                 830        
 Leu Pro Arg Ala Val Ile Ser Asn Leu Glu Glu Ser Leu Leu His Leu
         835                 840                 845            
 Lys Leu Cys Leu Leu Ala Gly Asn Gln Ser Leu Leu Val Gln Gln Ala
     850                 855                 860                
 Glu Glu Leu Gly Phe Ser Ile Leu Lys Arg Met Trp Pro Gly Trp Asn
 865                 870                 875                 880
 Ser Ile Thr Ile Leu Lys Pro Gln Gln Arg Trp Gln Val Thr Asp Ser
                 885                 890                 895    
 Pro Glu Leu Leu Thr Val Phe Ile His Asp Val Arg Thr Val Val Pro
             900                 905                 910        
 Val Arg Arg Lys Met Arg Lys Leu Arg Cys Lys Ala Val Lys Gln Leu
         915                 920                 925            
 Val Gln Asp Leu Asp Gln Val Glu Gly Glu Gln Gly Val Ser Leu Asn
     930                 935                 940                
 Phe His Ser
 945        



      <210> 1592
      <211> 1662
      <212> PRT
      <213> Homo sapiens


      <400> 1592
 Met Ser Val Ala Ser Phe Leu Gln Leu Pro Leu Ala Ala Gln Glu Gly
   1               5                  10                  15    
 Cys Gly Val Ala Trp Gln Gly Val Glu Thr Ala Ser Pro Gly Asp Gly
              20                  25                  30        
 Leu Gln Asp Arg Ala Asp Val Trp Gly Ser Trp Gly His Pro Leu Leu
          35                  40                  45            
 Glu Gly Thr Ala Ala Ser Gly Ala Gly Ser Ser Gly Ser Ser Glu Ala
      50                  55                  60                
 Cys Val Lys Asn Ile Gly Leu Ser Asp Ala Ser Val Phe Arg Gly Ser
  65                  70                  75                  80
 Phe Gly Gln Arg Val Ser Pro Ala Cys Arg Ser Thr Val Lys Pro Leu
                  85                  90                  95    
 Leu Ile Arg Trp Gln Ala Ala Leu Ser Arg Pro Pro Glu Leu Pro Ala
             100                 105                 110        
 Glu Pro Arg Gly Asp Leu Gln Glu Cys Ser Gln Pro Pro Pro Pro Ser
         115                 120                 125            
 Ser Pro Ala Val Gly Ser Leu Ala Pro Ala Ala Leu Ser Trp Gln Trp
     130                 135                 140                
 Gln Pro Leu Glu Gln Gly Met His Leu Glu Pro Cys Gln Pro Gln Pro
 145                 150                 155                 160
 Gly Lys Gly Ala Gln Ala Val Leu Gln Ala Val Ala Val His Ser Val
                 165                 170                 175    
 Glu Arg Val Cys Leu Ser Pro Leu His Gly Cys Thr Gln Cys Thr Cys
             180                 185                 190        
 Arg Lys Asp Met Val Lys Ile Ser Met Asp Val Phe Val Arg Ile Leu
         195                 200                 205            
 Gln Pro Glu Arg Tyr Glu Leu Trp Lys Gln Gly Lys Asp Leu Thr Val
     210                 215                 220                
 Leu Asp His Thr Arg Pro Thr Ala Leu Thr Ser Pro Glu Leu Ser Ser
 225                 230                 235                 240
 Trp Ser Ala Ser Arg Ala Ser Leu Lys Ala Lys Leu Leu Arg Arg Ser
                 245                 250                 255    
 His Arg Lys Arg Ser Gln Pro Lys Lys Pro Lys Pro Glu Asp Pro Lys
             260                 265                 270        
 Phe Pro Gly Glu Gly Thr Ala Gly Ala Ala Leu Leu Glu Glu Ala Gly
         275                 280                 285            
 Gly Ser Val Lys Glu Glu Ala Gly Pro Glu Val Asp Pro Glu Glu Glu
     290                 295                 300                
 Glu Glu Glu Pro Gln Pro Leu Pro His Gly Arg Glu Ala Glu Gly Ala
 305                 310                 315                 320
 Glu Glu Asp Gly Arg Gly Lys Leu Arg Pro Thr Lys Ala Lys Ser Glu
                 325                 330                 335    
 Arg Lys Lys Lys Ser Phe Gly Leu Leu Pro Pro Gln Leu Pro Pro Pro
             340                 345                 350        
 Pro Ala His Phe Pro Ser Glu Glu Ala Leu Trp Leu Pro Ser Pro Leu
         355                 360                 365            
 Glu Pro Pro Val Leu Gly Pro Gly Pro Ala Ala Met Glu Glu Ser Pro
     370                 375                 380                
 Leu Pro Ala Pro Leu Asn Val Val Pro Pro Glu Val Pro Ser Glu Glu
 385                 390                 395                 400
 Leu Glu Ala Lys Pro Arg Pro Ile Ile Pro Met Leu Tyr Val Val Pro
                 405                 410                 415    
 Arg Pro Gly Lys Ala Ala Phe Asn Gln Glu His Val Ser Cys Gln Gln
             420                 425                 430        
 Ala Phe Glu His Phe Ala Gln Lys Gly Pro Thr Trp Lys Glu Pro Val
         435                 440                 445            
 Ser Pro Met Glu Leu Thr Gly Pro Glu Asp Gly Ala Ala Ser Ser Gly
     450                 455                 460                
 Ala Gly Arg Met Glu Thr Lys Ala Arg Ala Gly Glu Gly Gln Ala Pro
 465                 470                 475                 480
 Ser Thr Phe Ser Lys Leu Lys Met Glu Ile Lys Lys Ser Arg Arg His
                 485                 490                 495    
 Pro Leu Gly Arg Pro Pro Thr Arg Ser Pro Leu Ser Val Val Lys Gln
             500                 505                 510        
 Glu Ala Ser Ser Asp Glu Gly Trp Ala Glu Asp Trp Ala Thr Gly Val
         515                 520                 525            
 Gly Thr Pro Leu Pro Gly Asp Ser Thr Pro Val Ser Thr Gly Asp Ala
     530                 535                 540                
 Gly Arg Gly Arg Gly Glu Ile Gly Val Arg Gln Leu Ala Met Glu Ala
 545                 550                 555                 560
 Ile Arg Val Gln Trp Glu Gln Ala Thr Glu Ala Ser Pro Phe Ser Gly
                 565                 570                 575    
 Glu Glu Asp Val Ser Asp Pro Asp Ala Leu Arg Pro Leu Leu Ser Leu
             580                 585                 590        
 Gln Trp Lys Asn Arg Ala Ala Ser Phe Gln Ala Glu Arg Lys Phe Asn
         595                 600                 605            
 Ala Ala Ala Ala Arg Thr Glu Pro Tyr Cys Ala Ile Cys Thr Leu Phe
     610                 615                 620                
 Tyr Pro Tyr Cys Gln Ala Leu Gln Thr Glu Lys Glu Ala Pro Ile Ala
 625                 630                 635                 640
 Ser Leu Gly Lys Gly Cys Pro Ala Thr Leu Pro Ser Lys Ser Arg Gln
                 645                 650                 655    
 Lys Thr Arg Pro Leu Ile Pro Glu Met Cys Phe Thr Ser Gly Gly Glu
             660                 665                 670        
 Asn Thr Glu Pro Leu Pro Ala Asn Ser Tyr Ile Gly Asp Asp Gly Thr
         675                 680                 685            
 Ser Pro Leu Ile Ala Cys Gly Lys Cys Cys Leu Gln Val His Ala Ser
     690                 695                 700                
 Cys Tyr Gly Ile Arg Pro Glu Leu Val Asn Glu Gly Trp Thr Cys Ser
 705                 710                 715                 720
 Arg Cys Ala Ala His Ala Trp Thr Ala Glu Cys Cys Leu Cys Asn Leu
                 725                 730                 735    
 Arg Gly Gly Ala Leu Gln Met Thr Thr Asp Arg Arg Trp Ile His Val
             740                 745                 750        
 Ile Cys Ala Ile Ala Val Pro Glu Ala Arg Phe Leu Asn Val Ile Glu
         755                 760                 765            
 Arg His Pro Val Asp Ile Ser Ala Ile Pro Glu Gln Arg Trp Lys Leu
     770                 775                 780                
 Ala Val Val Gly Cys Ala Ala Ala Asp Val Gly Val Trp Leu Trp Phe
 785                 790                 795                 800
 Gly Asp Ser Asp Val Ile Ser Cys Gly Tyr Arg Pro Ser Ser Gly Leu
                 805                 810                 815    
 Ala Gly Pro Ser Gly Ser Ser Val Phe Ser Thr Gly Gly Asn Cys Ser
             820                 825                 830        
 Pro Leu Arg Leu Asp Gly Leu Pro Ser Ala Pro Pro Gly Cys Arg Ala
         835                 840                 845            
 Phe Pro Phe Pro Ser Ser Ser Leu Thr Pro Thr Phe Asp Phe Phe Val
     850                 855                 860                
 Ala Ala Ala Leu Ala Ala Ala Asp Thr Val Pro Gly Val Asp Ile Gln
 865                 870                 875                 880
 Ala Cys Val Glu Val Gly Leu Glu Ala Asp Arg Ser Val Trp Gln Glu
                 885                 890                 895    
 Arg Ser Leu Phe Ile Thr Gly Ala Cys Asn Asp Glu Leu Lys Ile Leu
             900                 905                 910        
 Leu His Glu Ala Arg Leu Tyr Cys Leu Met Gly Leu Cys Lys Glu Ala
         915                 920                 925            
 Ala Val Asn Ser Cys Ser Pro Asn Arg Pro Ala Thr Phe Ala Gly His
     930                 935                 940                
 Gly Gln Ala Ala Gly Met Gly His Ser Leu Leu Val Thr His Pro Ser
 945                 950                 955                 960
 Val Cys Leu Gln Asp Phe Ser Ser His Arg Leu Arg Ala Pro Gly Ser
                 965                 970                 975    
 Pro Gly Glu Ser Gly Gly Ser Gly Trp Pro Pro Ala Trp Ala Lys Leu
             980                 985                 990        
 Ser Pro Arg Ser Gln Gly Arg Ala Ala Glu Lys Leu Leu Thr Tyr Arg
         995                1000                1005            
 Leu Gly Arg Phe Leu Ala Ala Gly Lys Ser Thr Gly Ser Ser Leu Glu
    1010                1015                1020                
 Asp Leu Gly Gly Arg Gly Ala Leu Gln Thr Ser Glu Ala His Pro Arg
1025                1030                1035                1040
 Arg Pro His Ser Pro Val Ala Ser Glu Glu Gly His Arg Ala Gly Asn
                1045                1050                1055    
 Phe Glu Pro Asn Thr Ser Ala Trp Ala Leu Pro Gly Pro Pro Arg Ala
            1060                1065                1070        
 Val Asp Pro Asp Ser Pro Ala His Thr Gly Leu Gly Gln Ala Ser Thr
        1075                1080                1085            
 Gly Cys Gly Ser Ser Asn Cys Gly Ser Gln Glu Gly Arg Ala His Leu
    1090                1095                1100                
 Cys Arg His Val Val Pro Leu Ala Glu Arg His His Lys Cys Val Tyr
1105                1110                1115                1120
 Cys Arg Lys Arg Met Lys Lys Val Ser Gly Ala Cys Ile Gln Cys Ser
                1125                1130                1135    
 Tyr Glu His Cys Ser Thr Ser Phe His Val Thr Cys Ala His Ala Ala
            1140                1145                1150        
 Gly Val Leu Met Glu Pro Asp Asp Trp Pro Tyr Val Val Ser Ile Thr
        1155                1160                1165            
 Cys Leu Lys His Lys Ser Gly Gly His Ala Val Gln Leu Leu Arg Ala
    1170                1175                1180                
 Val Ser Leu Gly Gln Val Val Ile Thr Lys Asn Arg Asn Gly Leu Tyr
1185                1190                1195                1200
 Tyr Arg Cys Arg Val Ile Gly Ala Ala Ser Gln Thr Cys Tyr Glu Val
                1205                1210                1215    
 Asn Phe Asp Asp Gly Ser Tyr Ser Asp Asn Leu Tyr Pro Glu Ser Ile
            1220                1225                1230        
 Thr Ser Arg Asp Cys Val Gln Leu Gly Pro Pro Ser Glu Gly Glu Leu
        1235                1240                1245            
 Val Glu Leu Arg Trp Thr Asp Gly Asn Leu Tyr Lys Ala Lys Phe Ile
    1250                1255                1260                
 Ser Ser Val Thr Ser His Ile Tyr Gln Ala Gly Pro Ala Arg Ser Pro
1265                1270                1275                1280
 Leu Ser Asp Leu Ser Leu Ser Ile Gln Asp Pro His Pro Arg Pro Cys
                1285                1290                1295    
 Arg Pro Thr Pro Pro Ser His His Ser Gln Pro Val Thr Glu His Pro
            1300                1305                1310        
 Gly Pro Pro Cys His Ala Gly Arg Pro Arg Pro Val Thr Ala Leu Gly
        1315                1320                1325            
 Pro Val Thr Glu His Pro Gly Pro Pro Pro Leu Arg Arg Ala Gly Arg
    1330                1335                1340                
 Pro Arg Pro Val Thr Thr Leu Asp Leu Ser Leu Ser Ile Gln Asp Leu
1345                1350                1355                1360
 Leu Ala Met Gln Ala Gly Pro Thr Arg Ser Pro Leu Ser Asp Leu Ala
                1365                1370                1375    
 Gly Ser Ser Leu Leu Leu Glu Lys Gly Val Val Ser Gly Thr Ser His
            1380                1385                1390        
 Pro His Gly Gln Pro Cys Gly Ser Tyr His Gln Ser Pro Asp Thr Val
        1395                1400                1405            
 Thr Ser Ala Gln Leu Gln Pro Ser Leu Gly Gly Gly Ser Gly Ser Ser
    1410                1415                1420                
 Leu Asp Phe Leu Ile Val Leu Gly Leu Asp Gln Gly Gln Gly Arg Phe
1425                1430                1435                1440
 Ala Pro Leu Ser Pro Ser Gln Ala Ala Ala Lys Glu Asn Asn Pro Cys
                1445                1450                1455    
 Ser Ala His Leu Ala Ala Leu Leu Ser Gly Tyr Glu Phe Gln Cys Gln
            1460                1465                1470        
 Ala Pro Glu Ser His Ile Pro Leu Gln Val Glu Phe Glu Asp Gly Ser
        1475                1480                1485            
 Gln Leu Thr Val Lys Arg Gly Asp Ile Phe Thr Leu Glu Glu Glu Leu
    1490                1495                1500                
 Pro Lys Arg Val Arg Ser Arg Leu Ser Leu Ser Thr Gly Ala Pro Gln
1505                1510                1515                1520
 Glu Pro Ala Phe Ser Gly Glu Glu Ala Lys Ala Ala Lys Arg Pro Arg
                1525                1530                1535    
 Val Gly Thr Pro Leu Ala Thr Glu Asp Ser Gly Arg Ser Gln Asp Tyr
            1540                1545                1550        
 Val Ala Phe Val Glu Ser Leu Leu Gln Lys Glu Cys Pro Pro Ala Cys
        1555                1560                1565            
 Cys Ala Glu Gly Leu Cys Pro Glu Gln Arg Val Pro Leu Thr Lys Lys
    1570                1575                1580                
 Leu His Pro Pro Thr Ala Pro Ser Thr Asp Ser Pro Phe Trp Gly Pro
1585                1590                1595                1600
 Leu Ala Ser Ser Ile Leu Ser Thr Pro Pro Gly Leu Ser Ser Pro Val
                1605                1610                1615    
 Cys Cys Arg Asp Ser Pro Ser Val Pro Arg Ser Thr Leu Ala Leu Lys
            1620                1625                1630        
 Gly Phe Gln Leu Asp Gly Gln Trp Ala Ala Asn Cys Pro Arg Cys His
        1635                1640                1645            
 Pro Gln Glu Arg Val Glu Lys Gly Gly Phe Asp Gln Gly Leu
    1650                1655                1660        



      <210> 1593
      <211> 870
      <212> PRT
      <213> Homo sapiens


      <400> 1593
 Met Ala Gly Leu Thr Ala Ala Ala Pro Arg Pro Gly Val Leu Leu Leu
   1               5                  10                  15    
 Leu Leu Ser Ile Leu His Pro Ser Arg Pro Gly Gly Lys Asp Pro Ser
              20                  25                  30        
 Pro Leu Ser Pro Ala Leu Pro Thr Ala Ala Gly Pro Leu Gly Gln Gly
          35                  40                  45            
 Asp Gln Ser Ile Leu Gly Glu Gly Pro Ala Gly Thr Pro Gly Ser Gly
      50                  55                  60                
 Asp Thr Thr Val Cys Thr Pro Val Asp Thr Ala Gly Val His Thr Ser
  65                  70                  75                  80
 Pro Gly Asp Arg Glu Pro Gly Leu Asp Thr Ser Ser Thr Ala Gly Ser
                  85                  90                  95    
 Leu Gly Pro Phe Leu Val Glu Phe Leu Glu Glu Ser Phe Ile Gln Val
             100                 105                 110        
 Thr Tyr Met Lys Leu Pro His Thr Gln Val Met Arg Met Met Leu Met
         115                 120                 125            
 Ser Ile Ile Asp Ala His Phe Asp Thr Thr Glu Gly Ala Gly Leu Gly
     130                 135                 140                
 Ala Leu Gly Gly Gly Ala Leu Gly Pro Gly Gly Lys Pro Leu Lys Pro
 145                 150                 155                 160
 Asp Ala Arg Ile Leu Gly Ala Phe Gly Ala Val Pro Gly Gly Leu Ala
                 165                 170                 175    
 Gly Ala Gly Leu Gly Ala Gly Leu Gly Ala Phe Pro Ala Val Thr Phe
             180                 185                 190        
 Pro Gly Ala Leu Val Pro Gly Gly Val Ala Asp Ala Ala Ala Ala Tyr
         195                 200                 205            
 Lys Ala Ala Lys Ala Gly Val Gly Leu Pro Gly Val Tyr Pro Gly Gly
     210                 215                 220                
 Val Leu Pro Gly Ala Arg Phe Pro Gly Val Gly Val Leu Pro Gly Val
 225                 230                 235                 240
 Pro Thr Gly Ala Gly Val Lys Pro Lys Ala Pro Gly Val Gly Gly Ala
                 245                 250                 255    
 Phe Ala Gly Ile Pro Gly Val Gly Pro Phe Gly Gly Pro Gln Pro Gly
             260                 265                 270        
 Val Pro Leu Gly Tyr Pro Ile Lys Ala Pro Lys Leu Pro Gly Gly Tyr
         275                 280                 285            
 Gly Leu Pro Tyr Thr Thr Gly Lys Leu Pro Tyr Gly Tyr Gly Pro Gly
     290                 295                 300                
 Gly Val Ala Gly Ala Ala Gly Lys Ala Gly Tyr Pro Thr Gly Thr Gly
 305                 310                 315                 320
 Val Gly Pro Gln Ala Ala Ala Ala Ala Ala Ala Lys Ala Ala Ala Lys
                 325                 330                 335    
 Phe Gly Ala Gly Ala Ala Gly Val Leu Pro Gly Val Gly Gly Ala Gly
             340                 345                 350        
 Val Pro Gly Val Pro Gly Ala Ile Pro Gly Ile Gly Gly Ile Ala Gly
         355                 360                 365            
 Val Gly Thr Pro Ala Ala Ala Ala Ala Ala Ala Ala Ala Ala Lys Ala
     370                 375                 380                
 Ala Lys Tyr Gly Ala Ala Ala Gly Leu Val Pro Gly Gly Pro Gly Phe
 385                 390                 395                 400
 Gly Pro Gly Val Val Gly Val Pro Gly Ala Gly Val Pro Gly Val Gly
                 405                 410                 415    
 Val Pro Gly Ala Gly Ile Pro Val Val Pro Gly Ala Gly Ile Pro Gly
             420                 425                 430        
 Ala Ala Val Pro Gly Val Val Ser Pro Glu Ala Ala Ala Lys Ala Ala
         435                 440                 445            
 Ala Lys Ala Ala Lys Tyr Gly Ala Arg Pro Gly Val Gly Val Gly Gly
     450                 455                 460                
 Ile Pro Thr Tyr Gly Val Gly Ala Gly Gly Phe Pro Gly Phe Gly Val
 465                 470                 475                 480
 Gly Val Gly Gly Ile Pro Gly Val Ala Gly Val Pro Gly Val Gly Gly
                 485                 490                 495    
 Val Pro Gly Val Gly Gly Val Pro Gly Val Gly Ile Ser Pro Glu Ala
             500                 505                 510        
 Gln Ala Ala Ala Ala Ala Lys Ala Ala Lys Tyr Gly Val Gly Thr Pro
         515                 520                 525            
 Ala Ala Ala Ala Ala Lys Ala Ala Ala Lys Ala Ala Gln Phe Gly Leu
     530                 535                 540                
 Val Pro Gly Val Gly Val Ala Pro Gly Val Gly Val Ala Pro Gly Val
 545                 550                 555                 560
 Gly Val Ala Pro Gly Val Gly Leu Ala Pro Gly Val Gly Val Ala Pro
                 565                 570                 575    
 Gly Val Gly Val Ala Pro Gly Val Gly Val Ala Pro Gly Ile Gly Pro
             580                 585                 590        
 Gly Gly Val Ala Ala Ala Ala Lys Ser Ala Ala Lys Val Ala Ala Lys
         595                 600                 605            
 Ala Gln Leu Arg Ala Ala Ala Gly Leu Gly Ala Gly Ile Pro Gly Leu
     610                 615                 620                
 Gly Val Gly Val Gly Val Pro Gly Leu Gly Val Gly Ala Gly Val Pro
 625                 630                 635                 640
 Gly Leu Gly Val Gly Ala Gly Val Pro Gly Phe Gly Ala Val Pro Gly
                 645                 650                 655    
 Ala Leu Ala Ala Ala Lys Ala Ala Lys Tyr Gly Pro Leu Pro Pro Arg
             660                 665                 670        
 Ala Ser Pro Glu Asp Val Ala Val Pro Gln Pro Leu His Leu Ala Leu
         675                 680                 685            
 Trp Gln Pro Cys Leu Ala Arg Pro Thr Leu Ser Val Ala Pro Glu Phe
     690                 695                 700                
 Leu Ala Ser Cys Glu Gln Arg Trp Trp Glu Val Glu Asp Ser Pro Arg
 705                 710                 715                 720
 Asp Pro Pro Thr Ser Arg Ala Gly Ala Ala Val Pro Gly Val Leu Gly
                 725                 730                 735    
 Gly Leu Gly Ala Leu Gly Gly Val Gly Ile Pro Gly Gly Val Val Gly
             740                 745                 750        
 Ala Gly Pro Ala Ala Ala Ala Ala Ala Ala Lys Ala Ala Ala Lys Ala
         755                 760                 765            
 Ala Gln Phe Gly Glu His Trp Val Glu Val Gly Ala Ala Ala Arg Pro
     770                 775                 780                
 Pro Gly Pro Gln Gly Ile Pro Pro Ala Ala Ala Ala Lys Ala Ala Lys
 785                 790                 795                 800
 Tyr Gly Ala Ala Gly Leu Gly Gly Val Leu Gly Gly Ala Gly Gln Phe
                 805                 810                 815    
 Pro Leu Gly Gly Val Ala Ala Arg Pro Gly Phe Gly Leu Ser Pro Ile
             820                 825                 830        
 Phe Pro Gly Ser Glu Leu Pro Val Cys Ala Ser Cys Gly Gln Arg Ile
         835                 840                 845            
 Tyr Asp Gly Gln Tyr Leu Gln Ala Leu Asn Ala Asp Trp His Ala Asp
     850                 855                 860                
 Cys Phe Arg Asn Asn Val
 865                 870



      <210> 1594
      <211> 258
      <212> PRT
      <213> Homo sapiens


      <400> 1594
 Met Thr Ile Leu Pro Lys Val Ile Tyr Arg Phe Ser Ala Ile Pro Ile
   1               5                  10                  15    
 Lys Leu Pro Met Thr Phe Phe Thr Glu Leu Glu Lys Thr Thr Leu Lys
              20                  25                  30        
 Phe Val Trp Asn Gln Lys Arg Ala Cys Ile Thr Lys Ser Ile Leu Ser
          35                  40                  45            
 Gln Lys Asn Lys Ala Gly Gly Ile Met Leu Pro Asp Val Lys Leu Tyr
      50                  55                  60                
 Tyr Lys Ala Thr Val Thr Lys Thr Ala Trp Phe Leu Gly Leu Gln Ser
  65                  70                  75                  80
 Gln Ile Gly Asn Tyr Pro Pro Thr Ala Leu Arg Leu Lys Pro Gly Leu
                  85                  90                  95    
 Thr Ser Ser Ala Pro Leu Val Leu Gly Pro Leu Asp Leu Gln Gly Ile
             100                 105                 110        
 Thr Pro Pro Thr Leu Leu Val Leu Gln Ile Val Glu Gln Met Ile Trp
         115                 120                 125            
 Val Leu Val Lys Gln Trp Pro Thr Ser Val Leu His Leu Ser Asp His
     130                 135                 140                
 Asp Asn Trp Phe Met Phe Gly His Lys Thr His Gln Leu Ile Lys Gly
 145                 150                 155                 160
 Cys Asp Phe Tyr Phe Ser Ala Arg Asp Gly Phe Gly Leu Val Val Val
                 165                 170                 175    
 Phe Arg Ser Gly Leu Thr Pro Cys Val Lys Val Asn Asn Thr Glu Gly
             180                 185                 190        
 Thr Ala Gln Ser Glu Gly Gln Ser Ala His Asn Tyr Arg Asn Ile Ala
         195                 200                 205            
 Val Leu Lys Ala Asp Phe Ile Thr Leu Cys Glu Cys Tyr Leu Ile Leu
     210                 215                 220                
 Thr Glu Asp Ser Glu Glu Glu Lys Ser Phe Met His Pro Ala Asp Leu
 225                 230                 235                 240
 Gln Cys Asn Ala Leu Ser Phe Leu Trp Arg Met Tyr Glu Asn Phe Gly
                 245                 250                 255    
 Arg Lys
        



      <210> 1595
      <211> 351
      <212> PRT
      <213> Homo sapiens


      <400> 1595
 Met Gln Gly Pro Ala Trp Leu Leu Thr Gln Val Thr Val Ala Val Val
   1               5                  10                  15    
 Thr Gly Ser Leu Phe Lys Leu Ile Leu Phe Cys Ser Met Val Phe Pro
              20                  25                  30        
 Ser Ser Arg Phe Ser Ser Gln Ser Pro His Thr Leu Ser Gly Ser Val
          35                  40                  45            
 Ser Gly Leu Val Pro Ser Thr Phe Pro His Leu Pro Trp Pro Ser Leu
      50                  55                  60                
 Glu Ala Ala Gly Glu Gly Thr Leu Ala Val Ala Val Ala Glu Gly Phe
  65                  70                  75                  80
 Ser Pro Val Phe Trp Asn Ser Thr Pro Glu Lys Cys Arg Ala Thr Thr
                  85                  90                  95    
 Asn Trp Cys Asn Gln Pro Gly Leu Thr Ile Tyr Val Gln Pro Glu Gln
             100                 105                 110        
 Lys His Thr Ala Glu Tyr Ala Ala Asn Ile Thr Lys Ser Val Phe Asp
         115                 120                 125            
 Tyr Phe Glu Glu Tyr Phe Ala Met Asn Tyr Ser Leu Pro Lys Leu Asp
     130                 135                 140                
 Lys Ile Ala Ile Pro Asp Phe Gly Thr Gly Ala Met Glu Asn Trp Gly
 145                 150                 155                 160
 Leu Ile Thr Tyr Arg Glu Thr Asn Leu Leu Tyr Asp Pro Lys Glu Ser
                 165                 170                 175    
 Ala Ser Ser Asn Gln Gln Arg Val Ala Thr Val Val Ala His Glu Leu
             180                 185                 190        
 Val His Gln Trp Phe Gly Asn Ile Val Thr Met Asp Trp Trp Glu Asp
         195                 200                 205            
 Leu Trp Leu Asn Glu Gly Phe Ala Ser Phe Phe Glu Phe Leu Gly Val
     210                 215                 220                
 Asn His Ala Glu Thr Asp Trp Gln Met Arg Asp Gln Met Leu Leu Glu
 225                 230                 235                 240
 Asp Val Leu Pro Val Gln Glu Asp Asp Ser Leu Met Ser Ser His Pro
                 245                 250                 255    
 Ile Ile Val Thr Val Thr Thr Pro Asp Glu Ile Thr Ser Val Phe Asp
             260                 265                 270        
 Gly Ile Ser Tyr Ser Lys Met Tyr Leu Glu Lys Tyr Gln Phe Lys Asn
         275                 280                 285            
 Ala Lys Thr Ser Asp Phe Trp Ala Ala Leu Glu Glu Ala Ser Arg Leu
     290                 295                 300                
 Pro Val Lys Glu Val Met Asp Thr Trp Thr Arg Gln Met Gly Tyr Pro
 305                 310                 315                 320
 Val Leu Asn Val Asn Gly Val Lys Asn Ile Thr Gln Lys Arg Phe Leu
                 325                 330                 335    
 Leu Asp Pro Arg Ala Asn Pro Ser Gln Pro Pro Ser Asp Leu Gly
             340                 345                 350    



      <210> 1596
      <211> 521
      <212> PRT
      <213> Homo sapiens


      <400> 1596
 Met Gln Ala Leu Cys Leu Phe Asn Leu Phe Phe Asn Ser Gly Ser Ser
   1               5                  10                  15    
 Arg Ile Pro Ala Leu Tyr Asn Asn Cys Gln Lys Gln Phe Leu Leu Cys
              20                  25                  30        
 Lys Arg Gly Gly Lys Lys Arg Ile Ser Tyr Lys Arg Asn Tyr Leu Met
          35                  40                  45            
 Glu Glu His Leu Glu Gly Leu Cys Ser Asn Glu Phe Thr Trp Glu Asn
      50                  55                  60                
 Ser Thr Ile Met Thr Asp Ser Gln Met Leu Met His Arg Glu Glu Pro
  65                  70                  75                  80
 Gly Ser Leu Pro Asn Ile Pro Ile Leu Ser Ile Val Phe Thr Asn Asn
                  85                  90                  95    
 His Ser Ala Ile Lys Leu Glu Leu Arg Ile Lys Lys Leu Thr Gln Asn
             100                 105                 110        
 Cys Ser Thr Thr Trp Lys Leu Asn Asn Leu Leu Leu Asn Asp Tyr Trp
         115                 120                 125            
 Val His Asn Glu Met Lys Ala Glu Ile Lys Met Phe Phe Glu Thr Asn
     130                 135                 140                
 Glu Asn Lys Asp Thr Thr Tyr Gln Asn Leu Trp Asp Thr Phe Lys Ala
 145                 150                 155                 160
 Val Ser Arg Pro Leu Ala Gln Glu Gln His Asp His Thr Leu Ile Glu
                 165                 170                 175    
 Trp Gln Trp Ala Ala Ile Arg Thr Val Trp Asn Asp Ala Gly Glu Ile
             180                 185                 190        
 Pro Lys Thr Glu Ser Lys Trp Gln Ser Tyr Ala Asn Leu Val Glu Val
         195                 200                 205            
 Ile Gln Glu Met Ala Ile Pro Ser Ile Met Asp Leu Met Asp Cys Leu
     210                 215                 220                
 Met Thr Glu Leu Gly Gln Tyr Asn Tyr Ile Tyr Lys Trp Leu Asp Pro
 225                 230                 235                 240
 Ser Cys Thr Asn Val Trp Gln His Val Ile Gly Leu Ser Met Asn Pro
                 245                 250                 255    
 Arg Ser Lys Asp Leu Asp Tyr Leu Pro Asn Ser Trp Glu Leu Pro Asp
             260                 265                 270        
 Gln Pro Cys Ser Met Ala Asp Gln Gln Asn Thr Ile Trp Ala Leu Lys
         275                 280                 285            
 Cys Val Cys Ala Leu Tyr Gly Arg Pro Leu Ala Thr Glu Val Ile Glu
     290                 295                 300                
 His Ile Ser Leu Asp Asn Arg Tyr Ile Pro Lys Met Ile Ser Ser Asp
 305                 310                 315                 320
 Gln Val Asn Met Leu Gln Leu His Cys Gly Leu Gly Pro His Leu His
                 325                 330                 335    
 Cys Ser Asp Gln Cys Phe Arg Leu Leu Asp Leu His Arg Pro Ser Ser
             340                 345                 350        
 Ser Ser Ser Glu Trp Leu Val Leu Ala His Thr Phe Ser Ile Cys Arg
         355                 360                 365            
 Glu Leu Asp Ile Thr Arg Tyr Leu Phe Phe Gln Cys Gly Cys Lys Ala
     370                 375                 380                
 Ile Ser Asn Asn Thr Val Ile Pro Val Cys Ala Leu Leu Ala Pro Leu
 385                 390                 395                 400
 Leu Arg Gln Pro Leu Gly Glu Arg Lys Lys Glu Met His Leu Thr Lys
                 405                 410                 415    
 Glu Val Lys Asp Val Tyr Lys Glu Asp Tyr Glu Thr Leu Pro Lys Glu
             420                 425                 430        
 Ile Ile Asp Gly Thr Asn Lys Trp Glu Ser Ile Pro Arg Trp Cys Val
         435                 440                 445            
 Glu Arg Ile Asn Met Ile Lys Met Ser Ile Leu Gly Gln Ser Arg Gly
     450                 455                 460                
 Lys His Lys Tyr Ser Asn His Ser Asn Ser Tyr Val Lys Thr Asn Thr
 465                 470                 475                 480
 Ser Phe Lys Ala Leu Leu Lys His Cys Leu Leu His Tyr Lys Lys Thr
                 485                 490                 495    
 Asp Glu Lys Val Thr Cys Phe Trp Gln Arg Val Ile Asn Trp Glu Ala
             500                 505                 510        
 Ala Val His Ser Leu Tyr Val Glu Gln
         515                 520    



      <210> 1597
      <211> 315
      <212> PRT
      <213> Homo sapiens


      <400> 1597
 Met Pro Thr Ala Ser Ile Thr Leu Gly Pro Gly Ala Leu Leu Ser Pro
   1               5                  10                  15    
 Ser Ser Leu Ala Gly Cys Pro Leu Ala Gln Leu Arg Pro Gly Pro Trp
              20                  25                  30        
 Pro Leu Gly Ser Trp Glu Val Gly His Ala His Ser Ser Thr Trp Leu
          35                  40                  45            
 Thr Val Val His Thr His Lys Pro His Phe Met Ala Leu His Cys Gln
      50                  55                  60                
 Glu Phe Gly Gly Lys Asn Tyr Glu Ala Ser Met Ser His Val Asp Lys
  65                  70                  75                  80
 Phe Val Lys Glu Leu Leu Ser Ser Asp Ala Met Lys Glu Tyr Asn Arg
                  85                  90                  95    
 Ala Arg Val Tyr Leu Asp Glu Asn Tyr Lys Ser Gln Glu His Phe Thr
             100                 105                 110        
 Val Gly Leu Ser Leu Leu Phe Gly Phe Lys Gly His Leu Thr Cys Leu
         115                 120                 125            
 Gly Ile Gln Cys Gln Leu Ile Asn Val Leu Val Pro Glu Met Val Thr
     130                 135                 140                
 Gln Leu Ser Cys Val Val Pro Thr Ser Ser Gly Val Cys Thr Ile Pro
 145                 150                 155                 160
 Gly Ile Pro Arg Ser Val Ser Asp Pro Arg Pro Val Lys Gln Leu Pro
                 165                 170                 175    
 Thr His Lys Arg Pro Leu Leu Thr Leu Cys Pro Arg Gly Leu Arg Leu
             180                 185                 190        
 Pro Pro His Leu Ala Phe Arg Val Phe Gln Leu Ser Gly Leu Gln Pro
         195                 200                 205            
 Arg Leu Pro Cys Leu Gly Thr Asp Leu Ile Ser Pro Thr Ala Thr Ala
     210                 215                 220                
 Leu Ser Glu Ala Leu Gly Gln Val Asp Gly Gly Gly Gln Pro Cys Leu
 225                 230                 235                 240
 Ala Ala Pro Thr Ala Gln Lys Ser Arg Val Leu Ser Ala Gly His Ala
                 245                 250                 255    
 Gly Ser Ser Glu Asn Thr Ser Val Ser Ala Gln Arg Ala Asp Val Gly
             260                 265                 270        
 Gln Arg Thr Gln Gly Asn Gly Phe Pro Glu Leu Arg Phe Gln Glu Gly
         275                 280                 285            
 Ser Arg Ala Gly Asn Asp Leu Leu Pro Gly Pro Ser Thr Cys Ser Pro
     290                 295                 300                
 Val Gly Arg Asp Asp Val Arg Leu Gly Leu Gln
 305                 310                 315



      <210> 1598
      <211> 170
      <212> PRT
      <213> Homo sapiens


      <400> 1598
 Met Arg Pro Trp Thr Gly Ser Trp Arg Trp Ile Met Leu Ile Leu Phe
   1               5                  10                  15    
 Ala Trp Gly Thr Leu Leu Phe Tyr Ile Gly Gly His Leu Val Arg Asp
              20                  25                  30        
 Asn Asp His Pro Asp His Ser Ser Arg Glu Leu Ser Lys Ile Leu Ala
          35                  40                  45            
 Lys Leu Glu Arg Leu Lys Gln Gln Asn Glu Asp Leu Arg Arg Met Ala
      50                  55                  60                
 Glu Ser Leu Arg Asp Val Val Leu Glu Pro Ser Gly Met Lys Gly Arg
  65                  70                  75                  80
 Ala Met Glu Leu Cys Leu Leu Pro Thr His Asn Lys Asp Gly Ser Asp
                  85                  90                  95    
 Gly Ser Val Glu Thr Gly Tyr Val Glu Cys Lys Glu Ile Thr Val Ile
             100                 105                 110        
 Leu Asp Met Leu Ile Tyr Ala Cys Tyr Ile Phe Asp Pro Thr Tyr Tyr
         115                 120                 125            
 Leu Val Gln Tyr Leu Trp His Asn Ile Ser Val Leu Ser Ala Gln Cys
     130                 135                 140                
 Val Leu Cys Leu Ile Ala Leu Gly Gly Cys Pro Leu Pro Val Phe Glu
 145                 150                 155                 160
 Gly Asp Asp Gly Met Asp Leu Gln Asn Ser
                 165                 170



      <210> 1599
      <211> 622
      <212> PRT
      <213> Homo sapiens


      <400> 1599
 Met Ala Ala Thr Val Leu Ala Thr Trp Trp Trp Glu Arg Gly Ala His
   1               5                  10                  15    
 Gly Glu Ala Leu Pro Gly Leu Lys Arg Asn Cys Ser Gln Met Lys Lys
              20                  25                  30        
 Thr Met Gln Gly Arg Ala Leu Arg Ala Glu Ser Gly Arg Cys Glu Gly
          35                  40                  45            
 Pro His Phe Thr Lys Gly Ser Leu Lys Gly Asp Val Glu Gln Met Gly
      50                  55                  60                
 Gln Gly Glu Glu Ser Phe Lys Gly Gln Val Glu Glu Thr Leu Ser His
  65                  70                  75                  80
 Pro Ala Asp Gln Gln Ala Gly Val Gly Glu Glu Pro Arg Glu Thr Gly
                  85                  90                  95    
 Lys Val Ser Ser Gln His Gln Gln Glu Arg Arg Asp Trp Pro Gly His
             100                 105                 110        
 Pro Val Leu Gln Gly Glu Arg Ala Asp Val Cys Ile Leu Gly Leu Leu
         115                 120                 125            
 Arg Leu Glu Glu Arg Arg Lys Glu Leu Leu Gln Lys Leu Glu Glu Thr
     130                 135                 140                
 Thr Lys Leu Thr Thr Tyr Leu His Ser Gln Leu Lys Ser Leu Ser Ala
 145                 150                 155                 160
 Ser Thr Leu Ser Met Ser Ser Gly Ser Ser Leu Gly Ser Leu Ala Ser
                 165                 170                 175    
 Ser Arg Gly Ser Leu Asn Thr Ser Ser Arg Gly Ser Leu Asn Ser Leu
             180                 185                 190        
 Ser Ser Thr Glu Leu Tyr Tyr Ser Ser Gln Ser Asp Gln Ile Asp Val
         195                 200                 205            
 Asp Tyr Gln Tyr Lys Leu Asp Phe Leu Leu Gln Glu Lys Ser Gly Tyr
     210                 215                 220                
 Ile Pro Ser Gly Pro Ile Thr Thr Ile His Glu Asn Glu Val Val Lys
 225                 230                 235                 240
 Ser Pro Ser Gln Pro Gly Gln Ser Gly Leu Cys Gly Val Ala Ala Ala
                 245                 250                 255    
 Ala Thr Gly His Thr Pro Pro Leu Ala Glu Ala Pro Lys Ser Val Ala
             260                 265                 270        
 Ser Leu Ser Ser Arg Ser Ser Leu Ser Ser Leu Ser Pro Pro Gly Ser
         275                 280                 285            
 Pro Leu Val Leu Glu Gly Thr Phe Pro Met Ser Ser Ser His Asp Ala
     290                 295                 300                
 Ser Leu His Gln Phe Thr Ala Asp Phe Glu Asp Cys Glu Leu Ser Ser
 305                 310                 315                 320
 His Phe Ala Asp Ile Ser Leu Ile Glu Asn Gln Ile Leu Leu Asp Ser
                 325                 330                 335    
 Asp Ser Gly Gly Ala Ser Gln Ser Leu Ser Glu Asp Lys Asp Leu Asn
             340                 345                 350        
 Glu Cys Ala Arg Glu Pro Leu Tyr Glu Gly Thr Ala Asp Val Glu Lys
         355                 360                 365            
 Ser Leu Pro Lys Arg Arg Val Ile His Leu Leu Gly Glu Lys Thr Thr
     370                 375                 380                
 Cys Val Ser Ala Ala Val Ser Asp Glu Ser Val Ala Gly Asp Ser Gly
 385                 390                 395                 400
 Val Tyr Glu Ala Phe Val Lys Gln Pro Ser Glu Met Glu Asp Val Thr
                 405                 410                 415    
 Tyr Ser Glu Glu Asp Val Ala Ile Val Glu Thr Ala Gln Val Gln Ile
             420                 425                 430        
 Gly Leu Arg Tyr Asn Ala Lys Ser Ser Ser Phe Met Val Ile Ile Ala
         435                 440                 445            
 Gln Leu Arg Asn Leu His Ala Phe Leu Ile Pro His Thr Ser Lys Val
     450                 455                 460                
 Tyr Phe Arg Val Ala Val Leu Pro Ser Ser Thr Asp Val Ser Cys Leu
 465                 470                 475                 480
 Phe Arg Thr Lys Val His Pro Pro Thr Glu Ser Ile Leu Phe Asn Asp
                 485                 490                 495    
 Val Phe Arg Val Ala Ile Ser Gln Thr Ala Leu Gln Gln Lys Thr Leu
             500                 505                 510        
 Arg Val Asp Leu Cys Ser Val Ser Lys His Arg Arg Glu Glu Cys Leu
         515                 520                 525            
 Ala Gly Thr Gln Ile Ser Leu Ala Asp Leu Pro Phe Ser Ser Glu Val
     530                 535                 540                
 Phe Thr Leu Trp Tyr Asn Leu Leu Pro Ser Lys Gln Met Pro Cys Lys
 545                 550                 555                 560
 Lys Asn Glu Glu Asn Glu Asp Ser Val Phe Gln Pro Asn Gln Pro Leu
                 565                 570                 575    
 Val Asp Ser Ile Asp Leu Asn Phe Pro Asp Asn Ile Glu Arg Asn Cys
             580                 585                 590        
 Lys Ser Arg His Pro Cys Leu Arg Pro Asp Leu Ser Gly Lys Ala Phe
         595                 600                 605            
 Ser Leu Ser Pro Leu Ser Met Asn Leu Ala Val Ala Phe Ser
     610                 615                 620        



      <210> 1600
      <211> 194
      <212> PRT
      <213> Homo sapiens


      <400> 1600
 Met Val Glu Gly Arg Leu Asp Gly Cys Ala Ser Leu Leu Leu Trp Gly
   1               5                  10                  15    
 Cys Ile Met Leu Leu Leu Leu Ala Lys Gly Ser Ala Leu Phe Phe Pro
              20                  25                  30        
 Thr Asp Val Ser Arg Cys Val Ala Glu Arg Lys Tyr Thr Gln Glu Gln
          35                  40                  45            
 Ala Arg Lys Glu Phe Gln Gln Val Phe Ile Pro Glu Cys Asn Asp Asp
      50                  55                  60                
 Gly Thr Tyr Ser Gln Val Thr Gly Leu Ala Trp Glu Val Leu His Pro
  65                  70                  75                  80
 Ser Cys Ala Leu Ser Gln Val Gln Cys His Ser Tyr Thr Gly Tyr Cys
                  85                  90                  95    
 Trp Cys Val Thr Pro Asn Gly Arg Pro Ile Ser Gly Thr Ala Val Ala
             100                 105                 110        
 His Lys Thr Pro Arg Cys Pro Gly Arg Ser Asp Val Pro Phe Gln Val
         115                 120                 125            
 Glu Gly Leu Lys Gly Ile Gly Leu Pro Phe Leu Leu Ile Ile Phe Pro
     130                 135                 140                
 Gly Phe Ile Gly Gly Pro Asp Gly Pro Arg Leu Cys Arg Leu Leu Glu
 145                 150                 155                 160
 Phe Leu Ala Trp Gln Val Cys Arg Val Ala Lys Val Cys Phe Leu Pro
                 165                 170                 175    
 Ser Phe Gln Ala Ala Leu Val Leu Val Ala Gly Pro Thr Leu Gln Ala
             180                 185                 190        
 Leu Gly
        



      <210> 1601
      <211> 132
      <212> PRT
      <213> Homo sapiens


      <400> 1601
 Met Ser Ser Lys Tyr Pro Arg Ser Val Arg Arg Cys Leu Pro Leu Cys
   1               5                  10                  15    
 Ala Leu Thr Leu Glu Ala Ala Leu Ile Leu Leu Phe Tyr Phe Phe Thr
              20                  25                  30        
 His Tyr Asp Ala Ser Leu Glu Asp Gln Lys Gly Leu Val Ala Ser Tyr
          35                  40                  45            
 Gln Gly Glu Ser Ser Leu Glu Gln Trp Ser Gln Glu Gln Ile Ala Gly
      50                  55                  60                
 Ala Gly Ala Gly Glu Ala Tyr Gly Ser Pro Gly Ala Gln Met Phe Leu
  65                  70                  75                  80
 Ser Thr Lys Ser Arg Gly Lys Asp Ser Pro Ile Phe Phe Arg Arg Leu
                  85                  90                  95    
 His Arg Asn Ser Val Asn Asn Gly Gln Cys Arg Ala Leu Gly Arg Lys
             100                 105                 110        
 Ala Leu Ser Ala Tyr Thr Trp Asn Gln Gly Ile Gly Ile Arg Gly Ser
         115                 120                 125            
 Ser Cys Ala Arg
     130        



      <210> 1602
      <211> 202
      <212> PRT
      <213> Homo sapiens


      <400> 1602
 Met Gly Leu Leu Gln Trp Leu Met Pro Ile Ile Pro Thr Leu Thr Gly
   1               5                  10                  15    
 Lys Pro Arg Leu Thr Thr Tyr Leu Asp Val Gln Arg Cys Leu Glu Tyr
              20                  25                  30        
 Leu Gly Tyr Leu Gly Tyr Ser Ile Leu Thr Glu Gln Glu Ser Gln Ala
          35                  40                  45            
 Ser Ala Val Thr Val Thr Arg Asp Lys Lys Ile Asp Leu Gln Lys Lys
      50                  55                  60                
 Gln Thr Gln Arg Asn Val Phe Arg Cys Asn Val Ile Gly Val Lys Asn
  65                  70                  75                  80
 Cys Gly Lys Ser Gly Val Leu Gln Ala Leu Leu Gly Arg Asn Leu Met
                  85                  90                  95    
 Arg Gln Lys Lys Ile Arg Glu Asp His Lys Ser Tyr Tyr Ala Ile Asn
             100                 105                 110        
 Thr Val Tyr Val Tyr Gly Gln Glu Lys Tyr Leu Leu Gln His Phe Met
         115                 120                 125            
 Asp Ser Arg Ile Pro Cys Leu Ile Val Ala Ala Lys Ser Asp Leu His
     130                 135                 140                
 Glu Val Lys Gln Glu Tyr Ser Ile Ser Pro Thr Asp Phe Cys Arg Lys
 145                 150                 155                 160
 His Lys Met Pro Pro Pro Gln Ala Phe Thr Cys Asn Thr Ala Asp Ala
                 165                 170                 175    
 Pro Ser Leu Val Leu Pro Gly Phe Leu Val Leu Gln Glu Thr Gly Asn
             180                 185                 190        
 Gln Gly Phe Gly Val Lys Phe Pro Asp Cys
         195                 200        



      <210> 1603
      <211> 317
      <212> PRT
      <213> Homo sapiens


      <400> 1603
 Met Asn Ser Gly Thr Leu Ser Thr Leu Leu Ile Asp Val Thr Gly Gly
   1               5                  10                  15    
 Met Phe Leu Trp Thr Phe Lys Val Met Asp His Ser Pro Val Ala Ile
              20                  25                  30        
 Gln Leu Ser Thr Ala Gly Ala Leu Val Gly Leu Glu Ser Ser Ile Leu
          35                  40                  45            
 Val Gln Ala Ser Val Cys Ser Gln Trp Ala Tyr His Val Leu Ser Arg
      50                  55                  60                
 Asn Val Glu Arg Gly Cys Leu Glu Gln Gly Ser Ala Gly Ile Thr Glu
  65                  70                  75                  80
 Gly Thr His Thr Leu Phe Glu Thr Ile Arg Ile Ala Lys Pro Gly Gln
                  85                  90                  95    
 Leu Val Gln Val Phe Ile Arg Leu Pro Ser Pro Ser Ala Glu Leu Asn
             100                 105                 110        
 Gly Cys Glu Arg His His Met Ala His Lys Ala Lys Ser Val Ser Ile
         115                 120                 125            
 Trp Leu Phe Pro Glu Glu Arg Ala Asp Pro Trp Leu Glu Pro Ala Glu
     130                 135                 140                
 His Leu Lys Pro Tyr Phe Gln Asn Thr Gly Tyr Phe Tyr Leu Arg Ile
 145                 150                 155                 160
 Leu Phe Ile Gly Leu Asp Lys Pro Lys Ala Ile Pro Phe Asn His Ile
                 165                 170                 175    
 Glu Val Val Ile Pro Pro Glu Ala Gln Glu Lys Ser Ile Gly Val Leu
             180                 185                 190        
 Val Asp Ala Gly Tyr Lys Cys Pro Gly Thr Lys Ser Gln Asn Met Gln
         195                 200                 205            
 Thr Gln His Pro Arg Ala Pro Ser Thr Asn Met Val Leu Leu Ala Cys
     210                 215                 220                
 Gln Ile Ile Pro Gln Phe Tyr Leu Asp Cys Leu His Asp Glu Ile Thr
 225                 230                 235                 240
 Thr Thr His Arg Ser Gly Ile Thr Cys Phe Gln Pro Leu Gly Gln Val
                 245                 250                 255    
 Arg Ser Arg Leu Thr Lys Phe His Asn Leu Lys Ala Val Val Cys Lys
             260                 265                 270        
 Ala Cys Met Lys Glu Asn Arg Arg Ile Thr Gly Arg Ala His Trp Gly
         275                 280                 285            
 Ser His His Ala Gly Gly Lys Gly Pro Gly Ala Ser Arg Ser Pro Thr
     290                 295                 300                
 Ser Val Asp Pro Asn Cys Phe Leu Ser Phe Val Asp Lys
 305                 310                 315        



      <210> 1604
      <211> 170
      <212> PRT
      <213> Homo sapiens


      <400> 1604
 Met Ala Trp Ala Leu Leu Leu Leu Thr Leu Leu Thr Gln Gly Thr Gly
   1               5                  10                  15    
 Ser Trp Ala Gln Ser Ala Leu Thr Gln Pro Pro Ser Val Ser Gly Ser
              20                  25                  30        
 Pro Gly Gln Ser Val Thr Ile Ser Cys Thr Gly Thr Ser Ser Asp Val
          35                  40                  45            
 Gly Ser Tyr Asn Arg Val Ser Trp Tyr Gln Gln Pro Pro Gly Thr Ala
      50                  55                  60                
 Pro Lys Leu Met Ile Tyr Glu Asn Phe Ser Asn Tyr Ile Leu Met Val
  65                  70                  75                  80
 Ile Ala Thr Thr Leu Ile Leu Asn Asn Ser Ala Ala Asn Ile Pro Thr
                  85                  90                  95    
 Gln Thr Pro Leu Ser Ser Cys Val Asn Met Thr Thr Gly Phe Ile Ser
             100                 105                 110        
 Lys Ser Glu Ile Ala Asp Val Ala Asp Ala Asp Leu Phe Ile Ser Ser
         115                 120                 125            
 Asn Leu Cys Lys Gln Ser Gly Lys Leu Asp Phe Ser Glu His Pro Asp
     130                 135                 140                
 Asp Asn Gly Arg Gly Gly Phe Val Ala Ser Arg Lys Leu Thr Pro Glu
 145                 150                 155                 160
 Pro Ala Val Ser Val Asp Ser Gln Gln Gly
                 165                 170



      <210> 1605
      <211> 693
      <212> PRT
      <213> Homo sapiens


      <400> 1605
 Met Gly Phe Arg Tyr Val Ala Gln Ala Gly Leu Thr Leu Leu Gly Ser
   1               5                  10                  15    
 Thr Ile Leu Pro Thr Phe Pro Pro Arg Val Leu Gly Leu Gln Leu Glu
              20                  25                  30        
 Ala Ser Val Ala Gly Gly Ala Phe Ala Gln Val Leu Leu Gly Pro Ala
          35                  40                  45            
 Gly Cys Val Leu Pro Thr Arg Thr Gly Arg Leu Cys Ser Thr Arg Ala
      50                  55                  60                
 Ile Ser Ser Asp Pro Thr Pro Ala Lys Gly Glu Pro Asp Met Asp Arg
  65                  70                  75                  80
 Gln Gly Val His Gly Gln Ala Ala Ala Ser Val Gly Thr Glu Glu Arg
                  85                  90                  95    
 Ser Gly Thr Gln Lys Leu Gly Asp Thr Arg Asn Tyr Arg Ala Pro Lys
             100                 105                 110        
 Arg Leu Ser Gln Pro Trp Phe Arg Glu Leu Leu Gly Leu Asp Ser Pro
         115                 120                 125            
 Lys Gly Gln Ser Ser Ser Val Leu Val Ala Gly Ser Met Ser Thr Ser
     130                 135                 140                
 Ala Ser Ala Ser Ala Ser Pro Phe Gln Ser Ala Trp Tyr Ser Glu Ser
 145                 150                 155                 160
 Glu Ile Thr Gln Gly Ala Arg Ser Arg Ser Gln Asn Gln Gln Arg Asp
                 165                 170                 175    
 His Asp Ser Lys Arg Pro Lys Leu Ser Cys Thr Asn Cys Thr Thr Ser
             180                 185                 190        
 Ala Gly Arg Asn Val Gly Asn Gly Leu Asn Thr Leu Ser Asp Val Gln
         195                 200                 205            
 Asp Arg Val Pro Ser Tyr Ser Gln Gly Ala Arg Pro Lys Glu Asn Ser
     210                 215                 220                
 Met Ser Thr Leu Gln Leu Asn Thr Ser Ser Thr Asn His Gln Leu Pro
 225                 230                 235                 240
 Ser Glu His Gln Thr Ile Leu Ser Ser Arg Asp Ser Arg Asn Ser Leu
                 245                 250                 255    
 Arg Ser Asn Phe Ser Ser Arg Glu Ser Glu Ser Ser Arg Ser Asn Thr
             260                 265                 270        
 Gln Pro Gly Phe Ser Tyr Ser Ser Ser Arg Asp Glu Ala Pro Ile Ile
         275                 280                 285            
 Ser Asn Ser Glu Arg Val Val Ser Ser Gln Arg Pro Phe Gln Glu Ser
     290                 295                 300                
 Ser Asp Asn Glu Gly Arg Arg Thr Thr Arg Arg Leu Leu Ser Arg Ile
 305                 310                 315                 320
 Ala Ser Ser Met Ser Ser Thr Phe Phe Ser Arg Arg Ser Ser Gln Asp
                 325                 330                 335    
 Ser Leu Asn Thr Arg Ser Leu Asn Ser Glu Asn Ser Tyr Val Ser Pro
             340                 345                 350        
 Arg Ile Leu Thr Ala Ser Gln Ser Arg Ser Asn Val Pro Ser Ala Ser
         355                 360                 365            
 Glu Val Pro Asp Asn Arg Ala Ser Glu Ala Ser Gln Gly Phe Arg Phe
     370                 375                 380                
 Leu Arg Arg Arg Trp Gly Leu Ser Ser Leu Ser His Asn His Ser Ser
 385                 390                 395                 400
 Glu Ser Asp Ser Glu Asn Phe Asn Gln Glu Ser Glu Gly Arg Asn Thr
                 405                 410                 415    
 Gly Pro Trp Leu Ser Ser Ser Leu Arg Asn Arg Cys Thr Pro Leu Phe
             420                 425                 430        
 Ser Arg Arg Arg Arg Glu Gly Arg Asp Glu Ser Ser Arg Ile Pro Thr
         435                 440                 445            
 Ser Asp Thr Ser Ser Arg Ser His Ile Phe Arg Arg Glu Ser Asn Glu
     450                 455                 460                
 Val Val His Leu Glu Ala Gln Asn Asp Pro Leu Gly Ala Ala Ala Asn
 465                 470                 475                 480
 Arg Pro Gln Ala Ser Ala Ala Ser Ser Ser Ala Thr Thr Gly Gly Ser
                 485                 490                 495    
 Thr Ser Asp Ser Ala Gln Gly Gly Arg Asn Thr Gly Ile Ser Gly Ile
             500                 505                 510        
 Leu Pro Gly Ser Leu Phe Arg Phe Ala Val Pro Pro Ala Leu Gly Ser
         515                 520                 525            
 Asn Leu Thr Asp Asn Val Met Ile Thr Val Asp Ile Ile Pro Ser Gly
     530                 535                 540                
 Trp Asn Ser Ala Asp Gly Lys Ser Asp Lys Thr Lys Ser Ala Pro Ser
 545                 550                 555                 560
 Arg Asp Pro Glu Arg Leu Gln Lys Ile Lys Glu Ser Leu Leu Leu Glu
                 565                 570                 575    
 Asp Ser Glu Glu Glu Glu Gly Asp Leu Cys Arg Ile Cys Gln Met Ala
             580                 585                 590        
 Ala Ala Ser Ser Ser Asn Leu Leu Ile Glu Pro Cys Lys Cys Thr Gly
         595                 600                 605            
 Ser Leu Gln Tyr Val His Gln Asp Cys Met Lys Lys Trp Leu Gln Ala
     610                 615                 620                
 Lys Ile Asn Ser Gly Ser Ser Leu Glu Ala Val Thr Thr Cys Glu Leu
 625                 630                 635                 640
 Cys Lys Glu Lys Leu Glu Leu Asn Leu Glu Asp Phe Asp Ile His Glu
                 645                 650                 655    
 Leu His Arg Ala His Ala Asn Glu Gln Val Ser Ile Phe Cys Leu Ile
             660                 665                 670        
 Trp Leu Thr Gln Gln Asn Ser Phe Glu Leu Lys Asn Cys Phe Tyr Gln
         675                 680                 685            
 Leu Gln Ile Ser Val
     690            



      <210> 1606
      <211> 837
      <212> PRT
      <213> Homo sapiens


      <400> 1606
 Met Ala Val Ile Ser Val Leu Ser Ala Ala Cys Leu Ala Leu Ala Ala
   1               5                  10                  15    
 Leu Leu Ala Ala Gln Leu Gln Asn Arg Ala Val Gly Arg Pro Lys Gly
              20                  25                  30        
 Lys Leu Gly Pro Ala Ser Ala Val Lys Leu Ala Ala Asn Arg Thr Thr
          35                  40                  45            
 Ala Gly Ala Arg Arg Arg Arg Thr Arg Cys Arg Lys Cys Glu Ala Cys
      50                  55                  60                
 Leu Arg Thr Glu Cys Gly Glu Cys His Phe Cys Lys Asp Met Lys Lys
  65                  70                  75                  80
 Phe Gly Gly Pro Gly Arg Met Lys Gln Ser Cys Ile Met Arg Gln Cys
                  85                  90                  95    
 Ile Ala Ala Pro Ala Cys Arg Pro Ala Cys Leu Thr Ala Ala Arg Ser
             100                 105                 110        
 Gly Arg Pro Ser Ala His Arg Glu Ala Gly Ala Val Asp Ser Pro Arg
         115                 120                 125            
 Ala Leu Pro Val Asp Gly Lys Ala Leu Ala Ala Ser Gln Ala Gln Ala
     130                 135                 140                
 Ser Cys Ser Phe Pro Pro Arg Val Leu Arg Ala Leu Leu Pro Gly Gly
 145                 150                 155                 160
 Arg Arg Ser Ser Leu Trp Arg Ser His Leu Pro Val Pro Val Glu Lys
                 165                 170                 175    
 Gln Ala Arg Leu Glu Gly Arg Asp Ser Ser Ala Leu Val Arg Ser Ser
             180                 185                 190        
 Ala Gly Pro Ala Trp His Arg Pro Val Leu Pro His Thr Ala Val Cys
         195                 200                 205            
 Leu Val Cys Gly Glu Ala Gly Lys Glu Asp Thr Val Glu Glu Glu Glu
     210                 215                 220                
 Gly Lys Phe Asn Leu Met Leu Met Glu Cys Ser Ile Cys Asn Glu Ile
 225                 230                 235                 240
 Ile His Pro Gly Cys Leu Lys Ile Lys Glu Ser Glu Gly Val Val Asn
                 245                 250                 255    
 Asp Glu Leu Pro Asn Cys Trp Glu Cys Pro Lys Cys Asn His Ala Gly
             260                 265                 270        
 Lys Thr Gly Lys Gln Lys Arg Gly Pro Gly Phe Lys Tyr Ala Ser Asn
         275                 280                 285            
 Leu Pro Gly Ser Leu Leu Lys Glu Gln Lys Met Asn Arg Asp Asn Lys
     290                 295                 300                
 Glu Gly Gln Glu Pro Ala Lys Arg Arg Ser Glu Cys Glu Glu Ala Pro
 305                 310                 315                 320
 Arg Arg Arg Ser Asp Glu His Ser Lys Lys Val Pro Pro Asp Gly Leu
                 325                 330                 335    
 Leu Arg Arg Lys Ser Asp Asp Val His Leu Arg Lys Lys Arg Lys Tyr
             340                 345                 350        
 Glu Lys Pro Gln Glu Leu Ser Gly Arg Lys Arg Arg Arg Ser Trp Lys
         355                 360                 365            
 Asn Ala Glu Asp Arg Met Ala Leu Ala Asn Lys Pro Leu Arg Arg Phe
     370                 375                 380                
 Lys Gln Glu Pro Glu Asp Glu Leu Pro Glu Ala Pro Pro Lys Thr Arg
 385                 390                 395                 400
 Glu Ser Asp His Ser Arg Ser Ser Ser Pro Thr Ala Gly Pro Ser Thr
                 405                 410                 415    
 Glu Gly Ala Glu Gly Pro Glu Glu Lys Lys Lys Val Lys Met Arg Arg
             420                 425                 430        
 Lys Arg Arg Leu Pro Asn Lys Glu Leu Ser Arg Glu Leu Ser Lys Glu
         435                 440                 445            
 Leu Asn His Glu Ile Gln Arg Thr Glu Asn Ser Leu Ala Asn Glu Asn
     450                 455                 460                
 Gln Gln Pro Ile Lys Ser Glu Pro Glu Ser Glu Gly Glu Glu Pro Lys
 465                 470                 475                 480
 Arg Pro Pro Gly Ile Cys Glu Arg Pro His Arg Phe Ser Lys Gly Leu
                 485                 490                 495    
 Asn Gly Thr Pro Arg Glu Leu Arg His Gln Leu Gly Pro Ser Leu Arg
             500                 505                 510        
 Ser Pro Pro Arg Val Ile Ser Arg Pro Pro Pro Ser Val Ser Pro Pro
         515                 520                 525            
 Lys Cys Ile Gln Met Glu Arg His Val Ile Arg Pro Pro Pro Ile Ser
     530                 535                 540                
 Pro Pro Pro Asp Ser Leu Pro Leu Asp Asp Gly Ala Ala His Val Met
 545                 550                 555                 560
 His Arg Glu Val Trp Met Ala Val Phe Ser Tyr Leu Ser His Gln Asp
                 565                 570                 575    
 Leu Cys Val Cys Met Arg Val Cys Arg Thr Trp Asn Arg Trp Cys Cys
             580                 585                 590        
 Asp Lys Arg Leu Trp Thr Arg Ile Asp Leu Asn His Cys Lys Ser Ile
         595                 600                 605            
 Thr Pro Leu Met Leu Ser Gly Ile Ile Arg Arg Gln Pro Val Ser Leu
     610                 615                 620                
 Asp Leu Ser Trp Thr Asn Ile Ser Lys Lys Gln Leu Ser Trp Leu Ile
 625                 630                 635                 640
 Asn Arg Leu Pro Gly Leu Arg Asp Leu Val Leu Ser Gly Cys Ser Trp
                 645                 650                 655    
 Ile Ala Val Ser Ala Leu Cys Ser Ser Ser Cys Pro Leu Leu Arg Thr
             660                 665                 670        
 Leu Asp Val Gln Trp Val Glu Gly Leu Lys Asp Ala Gln Met Arg Asp
         675                 680                 685            
 Leu Leu Ser Pro Pro Thr Asp Asn Arg Pro Gly Gln Met Asp Asn Arg
     690                 695                 700                
 Ser Lys Leu Arg Asn Ile Val Glu Leu Arg Leu Ala Gly Leu Asp Ile
 705                 710                 715                 720
 Thr Asp Ala Ser Leu Arg Leu Ile Ile Arg His Met Pro Leu Leu Ser
                 725                 730                 735    
 Lys Leu His Leu Ser Tyr Cys Asn His Val Thr Asp Gln Ser Ile Asn
             740                 745                 750        
 Leu Leu Thr Ala Val Gly Thr Thr Thr Arg Asp Ser Leu Thr Glu Ile
         755                 760                 765            
 Asn Leu Ser Asp Cys Asn Lys Val Thr Asp Gln Cys Leu Ser Phe Phe
     770                 775                 780                
 Lys Arg Cys Gly Asn Ile Cys His Ile Asp Leu Arg Tyr Cys Lys Gln
 785                 790                 795                 800
 Val Thr Lys Glu Gly Cys Glu Gln Phe Ile Ala Glu Met Ser Lys Ala
                 805                 810                 815    
 Ser Lys Leu Phe Leu Ala Ser Lys Gly Asn Gly Lys Glu Leu Tyr Ser
             820                 825                 830        
 Asp Asn Gly His Ala
         835        



      <210> 1607
      <211> 249
      <212> PRT
      <213> Homo sapiens


      <400> 1607
 Met Gly Pro Phe Lys Arg Arg Pro Ile Ser Pro Trp Leu Leu Phe Leu
   1               5                  10                  15    
 Met Asp Cys Phe Leu Ser Leu Phe Leu Trp His Ser Asp Val Glu Tyr
              20                  25                  30        
 Ser Asp Asp His Cys His Leu Ile Leu Pro Asp Ser Glu Ala Phe Gln
          35                  40                  45            
 Asp Val Gln Gly Lys Arg His Arg Gly Lys His Lys Phe Lys Val Lys
      50                  55                  60                
 Glu Met Tyr Leu Thr Lys Leu Leu Ser Thr Lys Leu Cys Gln Leu Thr
  65                  70                  75                  80
 Leu Ser Ser Ser Leu Gln Val Thr Leu Leu Ser Val Ala Cys Leu Pro
                  85                  90                  95    
 Leu Arg Phe Trp Val Asn Ile Leu Lys Asn Pro Gln Phe Val Phe Asp
             100                 105                 110        
 Ile Lys Lys Thr Pro His Ile Asp Gly Cys Leu Ser Val Ile Ala Gln
         115                 120                 125            
 Ala Phe Met Asp Ala Phe Ser Leu Thr Glu Gln Gln Leu Gly Lys Glu
     130                 135                 140                
 Ala Pro Thr Asn Lys Leu Leu Tyr Ala Lys Asp Ile Pro Thr Tyr Lys
 145                 150                 155                 160
 Glu Glu Val Lys Ser Tyr Tyr Lys Ala Ile Arg Asp Leu Pro Pro Leu
                 165                 170                 175    
 Ser Ser Ser Glu Met Glu Glu Phe Leu Thr Gln Glu Ser Lys Lys His
             180                 185                 190        
 Glu Asn Glu Phe Asn Glu Glu Val Ala Leu Thr Glu Ile Tyr Lys Tyr
         195                 200                 205            
 Ile Val Lys Tyr Phe Asp Glu Ile Leu Asn Lys Leu Glu Arg Glu Arg
     210                 215                 220                
 Gly Leu Glu Glu Ala Gln Lys Gln Leu Leu His Val Lys Val Leu Phe
 225                 230                 235                 240
 Asp Glu Lys Lys Lys Cys Lys Trp Met
                 245                



      <210> 1608
      <211> 427
      <212> PRT
      <213> Homo sapiens


      <400> 1608
 Met Ala Gly Gln Val Pro Leu Thr Pro His Tyr Cys Asp Leu Leu Leu
   1               5                  10                  15    
 Cys Leu Leu Ile Ser Leu Leu Ser Thr Leu Val Ile Thr Leu Val Pro
              20                  25                  30        
 Ser Ser Asp Ala Phe Asp Phe Glu Ile Gly Val Val Ile Val Arg Ile
          35                  40                  45            
 Ser Gln Gly Phe Asp Ile Ser Gln Val Leu Gln Val Gln Glu Glu Leu
      50                  55                  60                
 Glu Arg Leu Glu Gln Glu Arg Leu Ala Leu Glu Ala Thr Ile Lys Asp
  65                  70                  75                  80
 Asn Glu Cys Glu Glu Glu Ser Gly Gly Ile Arg Gly Leu Phe Lys Lys
                  85                  90                  95    
 Ala Gly Lys Leu Asn Ile Thr Lys Thr Thr Pro Lys Lys Asp Gly Ser
             100                 105                 110        
 Ile Asn Thr Ser Gln Ser Met His Val Gly Glu Phe Asn Gln Lys Leu
         115                 120                 125            
 Val Glu Ala Ser Thr Gln Phe Lys Lys Lys Gln Glu Lys Gly Thr Ile
     130                 135                 140                
 Asp Val Trp Trp Leu Phe Asp Asp Gly Gly Leu Thr Leu Leu Ile Pro
 145                 150                 155                 160
 Tyr Ile Leu Thr Leu Arg Lys Lys Trp Lys Asp Cys Lys Leu Arg Ile
                 165                 170                 175    
 Tyr Val Gly Gly Lys Ile Asn Arg Ile Glu Glu Glu Lys Ile Val Met
             180                 185                 190        
 Ala Ser Leu Leu Ser Lys Phe Arg Ile Lys Phe Ala Asp Ile His Ile
         195                 200                 205            
 Ile Gly Asp Ile Asn Ile Arg Pro Asn Lys Glu Ser Trp Lys Val Phe
     210                 215                 220                
 Glu Glu Met Ile Glu Pro Tyr Arg Leu His Glu Ser Cys Lys Asp Leu
 225                 230                 235                 240
 Thr Thr Ala Glu Lys Leu Lys Arg Glu Thr Pro Trp Lys Ile Thr Asp
                 245                 250                 255    
 Ala Glu Leu Glu Ala Val Lys Glu Lys Ser Tyr Arg Gln Val Arg Leu
             260                 265                 270        
 Asn Glu Leu Leu Gln Glu His Ser Arg Ala Ala Asn Leu Ile Val Leu
         275                 280                 285            
 Pro Trp Lys Ser His Cys Pro Tyr Lys Ser Leu Gln Gly Pro Thr Pro
     290                 295                 300                
 Ala Pro His Pro Pro Ile Ser Ala Thr Ser Thr Pro Thr Thr Val Tyr
 305                 310                 315                 320
 Ala Phe Leu Cys His Cys Ser Asp His Thr Gly Leu Leu Thr Val Lys
                 325                 330                 335    
 Gly Leu Asp Arg Gln Glu Asn Lys Leu His Ile Ile Ile Thr Asn Cys
             340                 345                 350        
 Glu Lys Tyr Cys Glu Gly Asn Lys Glu Lys Val Leu Arg Gln Asp Asn
         355                 360                 365            
 Ser Val Asp Leu Asp Ala Leu Cys Gly Arg Glu Leu Glu Arg Leu Leu
     370                 375                 380                
 Ser Leu Ser Pro Leu Ser Ala Thr Pro Pro Lys Arg Glu Pro Ala Ser
 385                 390                 395                 400
 Lys Arg Val Gln Gln Pro Glu Thr Thr Leu Glu Leu Ala His Tyr Ser
                 405                 410                 415    
 Ser Leu Ala Gly Ala Arg Ser Val Gln Ala Leu
             420                 425        



      <210> 1609
      <211> 195
      <212> PRT
      <213> Homo sapiens


      <400> 1609
 Met Ser Ser Glu Ser Leu Met Val Leu Lys Gly Phe Leu Leu Leu Ser
   1               5                  10                  15    
 Ser Ala Leu Tyr His Ser Pro Thr Ala Ser Ser Leu Leu Leu Gln Leu
              20                  25                  30        
 Asp Pro Ile Ser Leu Phe Leu Leu Asn His Pro Ala Glu Ile Tyr Lys
          35                  40                  45            
 Val Leu Asp Ala Ser Gly Pro Val Ile Glu Leu Ser Thr Gly Gln Asp
      50                  55                  60                
 Thr Ala Ser Asp Met Asn Glu Asn Pro Leu Lys Asn Phe Lys Leu Ile
  65                  70                  75                  80
 Leu Ile Leu Glu Glu His Pro Gly Asn Asn Leu Glu Gly Gly Phe Val
                  85                  90                  95    
 Gly Ser Thr Ile Tyr Asn Ser Lys Asp Thr Glu Ser Thr Glu Val Ser
             100                 105                 110        
 Ile Thr His Gly Leu Asp Lys Glu Asn Val Ile Gly Lys Val Asn Ile
         115                 120                 125            
 Asn Lys Met Val Ile Leu Pro Lys Ala Ile Tyr Arg Asp Asn Ala Ile
     130                 135                 140                
 Ser Val Lys Leu Pro Val Ile Met Phe Thr Glu Leu Glu Lys Lys Thr
 145                 150                 155                 160
 Met Gln Lys Phe Ile Trp Lys Glu Glu Gly Ala Gln Val Ala Lys Ala
                 165                 170                 175    
 Ile Leu Ser Lys Lys Asn Lys Thr Ile Gly Ile Thr Leu Ser Asn Phe
             180                 185                 190        
 Lys Val His
         195



      <210> 1610
      <211> 304
      <212> PRT
      <213> Homo sapiens


      <400> 1610
 Met Glu Pro Arg Ala Leu Val Thr Ala Leu Ser Leu Gly Leu Ser Leu
   1               5                  10                  15    
 Cys Ser Leu Gly Leu Leu Val Thr Ala Ile Phe Thr Asp His Trp Tyr
              20                  25                  30        
 Glu Thr Asp Pro Arg Arg His Lys Glu Ser Cys Glu Arg Ser Arg Ala
          35                  40                  45            
 Gly Ala Asp Pro Pro Asp Gln Lys Asn Arg Leu Met Pro Leu Ser His
      50                  55                  60                
 Leu Pro Leu Arg Asp Ser Pro Pro Leu Gly Arg Arg Leu Leu Pro Gly
  65                  70                  75                  80
 Gly Pro Gly Arg Ala Asp Pro Glu Ser Trp Arg Ser Leu Leu Gly Leu
                  85                  90                  95    
 Gly Gly Leu Asp Ala Glu Cys Gly Arg Pro Leu Phe Ala Thr Tyr Ser
             100                 105                 110        
 Gly Leu Trp Arg Lys Cys Tyr Phe Leu Gly Ile Asp Arg Asp Ile Asp
         115                 120                 125            
 Thr Leu Ile Leu Lys Gly Ile Ala Gln Arg Cys Thr Ala Ile Lys Tyr
     130                 135                 140                
 His Phe Ser Gln Pro Ile Arg Leu Arg Asn Ile Pro Phe Asn Leu Thr
 145                 150                 155                 160
 Lys Thr Ile Gln Gln Asp Glu Trp His Leu Leu Arg Lys Tyr Phe Gln
                 165                 170                 175    
 Glu Ser Tyr Ala Pro His Met Asn Cys Leu Ala Thr His Asn Gln Ile
             180                 185                 190        
 Ile Asp Ser Phe Lys Glu Glu Ser Val Pro Cys Pro Gly Ala Gln Pro
         195                 200                 205            
 Thr Gln Cys Leu Val Asp Gln Gly Glu Pro Lys Glu Cys Asp Ile Ser
     210                 215                 220                
 Pro Ser Lys Asn Leu Tyr Pro Tyr Ser Met Asp Gln Lys Ala Ile Met
 225                 230                 235                 240
 Gly Ile Leu Gln Leu Leu Arg Val Ala Ile Pro Ala Ile Asp Ser Asp
                 245                 250                 255    
 Thr Gly Phe Ile Cys Val Thr Val Leu Gly Ile Glu Arg Asp Val Ala
             260                 265                 270        
 Leu Phe Thr Ile Cys Lys Ala Pro Val Val Ile Phe Thr Lys Gln Gln
         275                 280                 285            
 Tyr Asn Gly Ser Ala Asn Met Lys His Ser Val Thr Lys Lys Lys Trp
     290                 295                 300                





      <210> 1611
      <211> 342
      <212> PRT
      <213> Homo sapiens


      <400> 1611
 Met Ala Glu Val Thr Leu Cys Asp Ile Gln Gly Lys Ile Arg Gln Gly
   1               5                  10                  15    
 Met Gln Leu Ala Trp Trp Leu Leu Leu Ala Ile Cys Ser Gly Ser Leu
              20                  25                  30        
 Gln Leu Pro Ser Lys Lys Phe Gly Phe His Glu Glu Gly His His Met
          35                  40                  45            
 Glu Lys Thr Ile Gln Arg Asp His Met Glu Arg Phe Lys Ser Cys Gly
      50                  55                  60                
 Ala Ala Thr Arg Glu Arg Gln Gly Pro Leu Pro Asp Ala Pro Ser Ala
  65                  70                  75                  80
 Val Thr Trp Ser Arg Asp Val Arg Val Ala Val Glu Ser Gly Gln Gln
                  85                  90                  95    
 Cys Ser Trp Ser Cys Val Leu Ala Leu Ala Ala Gly Thr Pro Arg Arg
             100                 105                 110        
 Ala Ala Asn Trp Tyr Arg Cys Pro Val Pro His Pro Trp His Arg Arg
         115                 120                 125            
 Pro Phe Asn Arg Arg Ser Arg Trp Trp Glu His Val Gly Leu Val Ser
     130                 135                 140                
 Pro Leu Val Ser Ser Pro Pro Ala Leu Met Gly Val Phe Val Cys Asp
 145                 150                 155                 160
 Leu Ala Ala Pro Gly Cys Arg Met Leu Pro Gly Lys Arg Cys Leu Gly
                 165                 170                 175    
 Asp Ala Leu Cys Leu Ala Glu Leu Arg Val Cys Trp Val Cys His Arg
             180                 185                 190        
 Asp Leu Thr Lys Ser Met Lys Ile Leu Ser Leu Arg Gly Gln Leu Arg
         195                 200                 205            
 Asn Gly Arg His Val Leu Tyr Tyr His Leu Arg Gln Gln Leu Ala Glu
     210                 215                 220                
 Arg Gly Asp Gly Ala Ala Glu Lys Met Leu Glu Ala Ser Arg Gly Trp
 225                 230                 235                 240
 Phe Met Arg Phe Asn Glu Arg Ser His Leu Tyr Asp Ile Lys Val Gln
                 245                 250                 255    
 Gly Glu Ala Ala Ser Ala His Val Glu Pro Ser Glu Ser Tyr Pro Glu
             260                 265                 270        
 Asp Leu Ala Lys Ile Ile Asn Glu Asp Lys Asn Arg Ala Leu His Ala
         275                 280                 285            
 Ala Glu Arg Leu Gln Thr Lys Leu Arg Glu Arg Gly Asp Val Ala Asn
     290                 295                 300                
 Glu Asp Lys Leu Ser Leu Leu Lys Ser Val Leu Gln Ser Pro Leu Phe
 305                 310                 315                 320
 Ser Gln Ile Leu Ser Leu Gln Thr Ser Val Gln Gln Leu Lys Asp Gln
                 325                 330                 335    
 Leu Phe Asp Ser Asp Ala
             340        



      <210> 1612
      <211> 510
      <212> PRT
      <213> Homo sapiens


      <400> 1612
 Met Ala Leu Phe Ala Val Phe Gln Thr Thr Phe Phe Leu Thr Leu Leu
   1               5                  10                  15    
 Ser Leu Arg Thr Tyr Gln Ser Glu Val Leu Ala Glu Arg Leu Pro Leu
              20                  25                  30        
 Thr Pro Val Ser Leu Lys Val Ser Thr Asn Ser Thr Arg Gln Ser Leu
          35                  40                  45            
 His Leu Gln Trp Thr Val His Asn Leu Pro Tyr His Gln Glu Leu Lys
      50                  55                  60                
 Met Val Phe Gln Ile Gln Ile Ser Arg Ile Glu Thr Ser Asn Val Ile
  65                  70                  75                  80
 Trp Val Gly Asn Tyr Ser Thr Thr Val Lys Trp Asn Gln Val Leu His
                  85                  90                  95    
 Trp Ser Trp Glu Ser Glu Leu Pro Leu Glu Cys Ala Thr His Phe Val
             100                 105                 110        
 Arg Ile Lys Ser Leu Val Asp Asp Ala Lys Phe Pro Glu Pro Asn Phe
         115                 120                 125            
 Trp Ser Asn Trp Ser Ser Trp Glu Glu Val Ser Asp Lys Leu Val Glu
     130                 135                 140                
 Glu Gly Thr Asn Val Thr Ile Cys Tyr Val Ser Arg Asn Ile Gln Asn
 145                 150                 155                 160
 Asn Val Ser Cys Tyr Leu Glu Gly Lys Gln Ile His Gly Glu Gln Leu
                 165                 170                 175    
 Asp Pro His Val Thr Ala Phe Asn Leu Asn Ser Val Pro Phe Ile Arg
             180                 185                 190        
 Asn Lys Gly Thr Asn Ile Tyr Cys Glu Ala Ser Gln Gly Asn Val Ser
         195                 200                 205            
 Glu Gly Met Lys Gly Ile Val Leu Phe Val Ser Ser Leu Trp Thr Asn
     210                 215                 220                
 Arg Glu Leu Pro Gly Val Phe Arg Glu Val Pro Phe Lys Thr Thr Trp
 225                 230                 235                 240
 Ser Ser Thr Gly Leu Gly Ser Leu Ser Asn Leu Val Leu Ala Ala Val
                 245                 250                 255    
 Ala Pro Ile Ala Ala Ile Ala Thr Leu Leu Asn Pro Asn Gly Asn Ser
             260                 265                 270        
 Glu Met Thr Asp Lys Glu Phe Lys Ala Ser Ile Val Arg Arg Leu Glu
         275                 280                 285            
 Glu Ile Gln Asp Lys Val Glu Asn Gln His Glu Glu Thr Ser Lys Ser
     290                 295                 300                
 Asp Pro Glu Met Pro Ala Lys Ser Gln Gly Leu Glu Ser Glu Thr Pro
 305                 310                 315                 320
 Arg Ala His Leu Cys Ser Thr Pro Val Ser Asn Asp Ser Phe Ser Asp
                 325                 330                 335    
 Met Met Ser Lys Pro Gly Thr Val Ser Ala Tyr Leu Thr Phe Gln Ser
             340                 345                 350        
 Tyr Glu Val Tyr Leu Met Asn Pro Phe Ser Val Asn Phe Glu Asn Val
         355                 360                 365            
 Asn Ala Thr Asn Ala Ile Met Thr Trp Lys Val His Ser Ile Arg Asn
     370                 375                 380                
 Asn Phe Thr Tyr Leu Cys Gln Ile Glu Leu His Gly Glu Gly Lys Met
 385                 390                 395                 400
 Met Gln Tyr Asn Val Ser Ile Lys Val Asn Gly Glu Tyr Phe Leu Ser
                 405                 410                 415    
 Glu Leu Glu Pro Ala Thr Glu Tyr Met Ala Arg Val Arg Cys Ala Asp
             420                 425                 430        
 Ala Ser His Phe Trp Lys Trp Ser Glu Trp Ser Gly Gln Asn Phe Thr
         435                 440                 445            
 Thr Leu Glu Ala Asp His Thr Ser Ile Leu Ala Met Val Leu Asn Leu
     450                 455                 460                
 Phe Lys Met Thr Glu Leu Glu Phe Arg Ile Trp Ile Glu Thr Lys Ile
 465                 470                 475                 480
 Ile Asn Ile Gln Glu Lys Val Lys Thr Gln Ser Lys Glu Ser Lys Glu
                 485                 490                 495    
 Tyr Asn Lys Met Thr Gln Glu Ile Lys Asp Lys Met Ser Ile
             500                 505                 510



      <210> 1613
      <211> 279
      <212> PRT
      <213> Homo sapiens


      <400> 1613
 Met Val Gln Leu Leu Pro Ser Trp Ala Gly Leu Arg Ser Leu Thr Trp
   1               5                  10                  15    
 Ile Leu Ala Ser Gln Ile Pro Arg Asn Glu Pro Trp Pro Met Arg Tyr
              20                  25                  30        
 Gly Thr Val Asn Arg Ala Ile Lys Ser Leu Ser Ile Leu Leu Glu Ala
          35                  40                  45            
 Ala Glu Lys Gly Asp Pro Glu Thr Trp Tyr Thr Ser Lys Lys Gly Gln
      50                  55                  60                
 Glu Ser Phe Glu Gly Ile Lys Glu Val Ile Arg Asp Leu Ser Met Val
  65                  70                  75                  80
 Thr Ile Gly Ser Arg Ile Glu Gln Thr Gln Phe Arg Gly Gln Lys Ile
                  85                  90                  95    
 Lys Asp Ser Ala Lys Glu Gly Pro Glu Val Arg Ala Asp Ser Arg Arg
             100                 105                 110        
 Glu Ala Ala Cys Leu Phe Gly Lys Lys Asn Leu Pro Thr Leu Ala Tyr
         115                 120                 125            
 Asp Leu Trp Ser Tyr Leu Phe Phe Ser Cys Phe Lys Ser Pro Lys Glu
     130                 135                 140                
 Pro Glu Gln Leu Gln Lys Leu Phe Ile Gly Glu Leu Ser Phe Glu Thr
 145                 150                 155                 160
 Thr Asp Glu Ser Leu Arg Ser His Ser Glu Gln Trp Gly Met Leu Met
                 165                 170                 175    
 Asp Cys Val Val Met Arg Asp Pro Asn Thr Lys Cys Ser Arg Gly Phe
             180                 185                 190        
 Gly Phe Val Thr Tyr Ala Thr Val Glu Glu Val Asp Ala Ala Met Asn
         195                 200                 205            
 Ala Arg Pro His Lys Val Asp Gly Arg Val Val Glu Pro Lys Ser Cys
     210                 215                 220                
 Leu Lys Arg Arg Phe Ser Lys Thr Ser Gly Ser Arg Gly Gly Val Glu
 225                 230                 235                 240
 Tyr Gly Ser Ser Gly Asp Gly Tyr Asn Gly Phe Gly Asn Asp Gly Ser
                 245                 250                 255    
 Asn Phe Gly Gly Gly Lys Ser Tyr Ser Asp Leu Ala Ile Ile Thr Ile
             260                 265                 270        
 Ser Leu Gln Ile Leu Asp Pro
         275                



      <210> 1614
      <211> 206
      <212> PRT
      <213> Homo sapiens


      <400> 1614
 Met Leu Ala Leu Leu Ser Pro Leu Ser Leu Ala Gln Tyr Asp Ser Trp
   1               5                  10                  15    
 Pro His Tyr Pro Glu Tyr Phe Gln Gln Pro Ala Pro Glu Tyr His Gln
              20                  25                  30        
 Pro Gln Ala Pro Ala Asn Val Ala Lys Ile Gln Leu Arg Leu Ala Gly
          35                  40                  45            
 Gln Lys Arg Lys His Ser Glu Gly Arg Val Glu Val Tyr Tyr Asp Gly
      50                  55                  60                
 Gln Trp Gly Thr Val Cys Asp Asp Asp Phe Ser Ile His Ala Ala His
  65                  70                  75                  80
 Val Val Cys Arg Glu Leu Gly Tyr Val Glu Ala Lys Ser Trp Thr Val
                  85                  90                  95    
 Ser Ser Ser Tyr Gly Lys Gly Glu Gly Pro Ile Trp Leu Asp Asn Leu
             100                 105                 110        
 His Cys Thr Gly Asn Glu Ala Thr Leu Ala Ala Cys Thr Ser Asn Gly
         115                 120                 125            
 Trp Gly Val Thr Asp Cys Lys His Thr Glu Asp Val Gly Val Val Cys
     130                 135                 140                
 Ser Asp Lys Arg Ile Pro Gly Phe Lys Phe Asp Asn Ser Leu Ile Asn
 145                 150                 155                 160
 Gln Ile Glu Ala Ser His Asp His Glu Leu Ile Cys Asn Ile Leu Asp
                 165                 170                 175    
 Gly Pro Leu Phe Asn Leu Asn Leu Arg Ile Ile Tyr Leu Glu Cys Pro
             180                 185                 190        
 Val Lys Thr Gln Pro Ser Trp His Lys Lys Val Ile Asp His
         195                 200                 205    



      <210> 1615
      <211> 118
      <212> PRT
      <213> Homo sapiens


      <400> 1615
 Met Val Gln Phe Asp His Arg Ile Leu Arg Ile Cys Phe Glu Gly Leu
   1               5                  10                  15    
 Leu Trp Ala Ile Gln Arg Leu Ala Trp Arg Pro Val Cys Asp Glu Leu
              20                  25                  30        
 Glu Arg Gly Lys Met Ser Ser Lys Glu Thr Val Arg Ser Ile Val Leu
          35                  40                  45            
 Leu Arg Asn Ala Arg Glu Ser Asp Gly Asp Gly Ala Tyr Met Val Gly
      50                  55                  60                
 Leu Gly Ile Ser Thr Leu Leu Met Tyr Val Pro Thr Pro Leu Ala Ala
  65                  70                  75                  80
 Thr His Gln Ser Gly Ser Leu Ala Leu Leu Thr Gly Phe Val Ser Gly
                  85                  90                  95    
 Phe Ser Val Leu Ala Ser Ser Trp Phe Tyr Val Asp Asp Phe Tyr Val
             100                 105                 110        
 Asp Val Leu Leu Ser Pro
         115            



      <210> 1616
      <211> 559
      <212> PRT
      <213> Homo sapiens


      <400> 1616
 Met Leu Leu Pro Leu Leu Leu Leu Leu Pro Met Cys Trp Ala Val Glu
   1               5                  10                  15    
 Val Lys Arg Pro Arg Gly Val Ser Leu Thr Asn His His Phe Tyr Asp
              20                  25                  30        
 Glu Ser Lys Pro Phe Thr Cys Leu Asp Gly Ser Ala Thr Ile Pro Phe
          35                  40                  45            
 Asp Gln Val Asn Asp Asp Tyr Cys Asp Cys Lys Asp Gly Ser Asp Glu
      50                  55                  60                
 Pro Gly Thr Ala Ala Cys Pro Asn Gly Ser Phe His Cys Thr Asn Thr
  65                  70                  75                  80
 Gly Tyr Lys Pro Leu Tyr Ile Pro Ser Asn Arg Val Asn Asp Gly Val
                  85                  90                  95    
 Cys Asp Cys Cys Asp Gly Thr Asp Glu Tyr Asn Ser Gly Val Ile Cys
             100                 105                 110        
 Glu Asn Thr Cys Lys Tyr Val Gly Asp Ser Thr Pro Pro Ile Thr Pro
         115                 120                 125            
 Pro Gln Asp Phe Ala Trp Leu His Pro Val Asn Arg Ala His Ser Leu
     130                 135                 140                
 Phe Cys Phe Ser Val Ser Gly Ser Leu Ser Val Pro Gly Ala Leu Glu
 145                 150                 155                 160
 Lys Gly Arg Lys Glu Arg Glu Ser Leu Gln Gln Met Ala Glu Val Thr
                 165                 170                 175    
 Arg Glu Gly Phe Arg Leu Lys Lys Ile Leu Ile Glu Asp Trp Lys Lys
             180                 185                 190        
 Ala Arg Glu Glu Lys Gln Lys Lys Leu Ile Glu Leu Gln Ala Gly Lys
         195                 200                 205            
 Lys Ser Leu Glu Asp Gln Val Glu Met Leu Arg Thr Val Lys Glu Glu
     210                 215                 220                
 Ala Glu Lys Pro Glu Arg Glu Ala Lys Glu Gln His Gln Lys Leu Trp
 225                 230                 235                 240
 Glu Glu Gln Leu Ala Ala Ala Lys Ala Gln Gln Glu Gln Glu Leu Ala
                 245                 250                 255    
 Ala Asp Ala Phe Lys Glu Leu Asp Asp Asp Met Asp Gly Thr Gly Asp
             260                 265                 270        
 Thr Gln Thr Asp Ala Thr Ser Phe Tyr Asp Arg Val Trp Ala Ala Ile
         275                 280                 285            
 Arg Asp Lys Tyr Arg Ser Glu Ala Leu Pro Thr Asp Leu Pro Ala Pro
     290                 295                 300                
 Ser Ala Pro Asp Leu Thr Glu Pro Lys Glu Glu Gln Pro Pro Val Pro
 305                 310                 315                 320
 Ser Ser Pro Thr Glu Glu Glu Glu Glu Glu Glu Glu Glu Glu Glu Glu
                 325                 330                 335    
 Glu Ala Glu Glu Glu Glu Glu Glu Glu Asp Ser Glu Val Gln Gly Glu
             340                 345                 350        
 Gln Pro Lys Glu Ala Pro Pro Pro Leu Ser Pro Pro Gln Pro Ala Ser
         355                 360                 365            
 Pro Ala Glu Glu Asp Lys Met Pro Pro Tyr Asp Glu Gln Thr Gln Ala
     370                 375                 380                
 Phe Ile Asp Ala Ala Gln Glu Ala Arg Asn Lys Phe Glu Glu Ala Glu
 385                 390                 395                 400
 Arg Ser Leu Lys Asp Met Glu Glu Ser Ile Arg Asn Leu Glu Gln Glu
                 405                 410                 415    
 Ile Ser Phe Asp Phe Gly Pro Asn Gly Glu Phe Ala Tyr Leu Tyr Ser
             420                 425                 430        
 Gln Cys Tyr Glu Leu Thr Thr Asn Glu Cys Val Pro Gly Met Gln Gly
         435                 440                 445            
 Pro Pro Leu Ala Gly Tyr Val Tyr Arg Leu Cys Pro Phe Lys Leu Val
     450                 455                 460                
 Ser Gln Lys Pro Lys Leu Gly Gly Ser Pro Thr Ser Leu Gly Thr Trp
 465                 470                 475                 480
 Gly Ser Trp Ile Gly Pro Asp His Asp Lys Phe Ser Ala Met Lys Tyr
                 485                 490                 495    
 Glu Gln Gly Thr Gly Cys Trp Gln Gly Pro Asn Arg Ser Thr Thr Val
             500                 505                 510        
 Arg Leu Leu Cys Gly Lys Glu Thr Met Val Thr Ser Thr Thr Glu Pro
         515                 520                 525            
 Ser Arg Cys Glu Tyr Leu Met Glu Leu Met Thr Pro Ala Ala Cys Pro
     530                 535                 540                
 Glu Pro Pro Pro Glu Ala Pro Thr Glu Asp Asp His Asp Glu Leu
 545                 550                 555                



      <210> 1617
      <211> 238
      <212> PRT
      <213> Homo sapiens


      <400> 1617
 Met Gly Gly Val Arg Ala Pro Ala Thr Lys Gln Leu Leu Glu Ala Leu
   1               5                  10                  15    
 Phe Gly Val Val Arg Ser Gly Phe Asn Leu His Phe Ser Ala Ala Met
              20                  25                  30        
 Leu Lys Val Gly Pro Leu Trp Cys Leu Gly Ala Phe Leu Leu Thr Thr
          35                  40                  45            
 Lys Thr Phe His Val Asn Ile Val Val Asp Ile Cys Phe Asp Ile Thr
      50                  55                  60                
 Pro Lys Val Ser Met Gly Arg Phe Leu Lys Glu Ser Val Ser Pro Gly
  65                  70                  75                  80
 Lys Met Ser Arg Ser Gln Trp Gln Thr Glu Val Phe Gln Thr Ser Gln
                  85                  90                  95    
 Asn Thr Gly Pro Ser Phe Arg Ala Trp Phe Glu Phe Ser Phe Ile His
             100                 105                 110        
 Leu Pro Ala Leu Ser Asp Phe Leu Asn Leu Phe Leu Tyr Val Cys Cys
         115                 120                 125            
 Ala Val Ile Lys Ile Lys Trp Gln Glu Ser Val Asn Met Cys Lys Val
     130                 135                 140                
 Phe Arg Met Met Ser Gly Pro Asp Val Pro Pro Ala Asp Gln Glu Lys
 145                 150                 155                 160
 Leu Phe Ile Gln Lys Leu Arg Gln Cys Cys Val Leu Phe Asp Phe Val
                 165                 170                 175    
 Ser Asp Pro Leu Ser Asp Leu Lys Trp Lys Glu Val Lys Arg Ala Ala
             180                 185                 190        
 Leu Ser Glu Met Val Glu Tyr Ile Thr His Asn Arg Asn Val Ile Thr
         195                 200                 205            
 Glu Pro Ile Tyr Pro Glu Val Val His Met Asn Pro Lys Leu Tyr Ser
     210                 215                 220                
 Cys Cys Thr Pro Asp Ala Ala Thr Phe Lys Tyr Pro Ala Tyr
 225                 230                 235            



      <210> 1618
      <211> 432
      <212> PRT
      <213> Homo sapiens


      <400> 1618
 Met Ala Lys Ser Gly Pro Leu Ala Ala Gly Leu Leu Glu Phe Ala Gly
   1               5                  10                  15    
 Gly Pro Leu Gln Thr Leu Phe Ala Trp Val Ser Ala Ala Glu Ala Ala
              20                  25                  30        
 Glu Gln Pro Ile Leu Leu Asn Ser Lys Cys Cys Cys Leu Ile Val Pro
          35                  40                  45            
 Leu Glu Ala Ser Ser Trp Arg Gly Thr Arg Pro Cys Glu Val Ile Val
      50                  55                  60                
 Ser Glu Ala Gly Ala Ser Ile Tyr Ser Val Ser Pro Glu Ala Asn Lys
  65                  70                  75                  80
 Glu Met Pro Gly Leu Asp Pro Asn Leu Arg Ser Ala Val Ser Ile Ala
                  85                  90                  95    
 Arg Arg Val Gln Asp Pro Leu Ala Glu Leu Val Lys Ile Glu Pro Lys
             100                 105                 110        
 His Ile Gly Val Gly Met Tyr Gln His Asp Val Ser Gln Thr Leu Leu
         115                 120                 125            
 Lys Ala Thr Leu Asp Ser Val Val Glu Glu Cys Val Ser Phe Val Gly
     130                 135                 140                
 Val Asp Ile Asn Ile Cys Ser Glu Val Leu Leu Arg His Ile Ala Gly
 145                 150                 155                 160
 Leu Asn Ala Asn Arg Ala Lys Asn Ile Ile Glu Trp Arg Glu Lys Asn
                 165                 170                 175    
 Gly Pro Phe Ile Asn Arg Glu Gln Leu Lys Lys Val Lys Gly Leu Gly
             180                 185                 190        
 Pro Lys Ser Phe Gln Gln Cys Ala Gly Phe Ile Arg Ile Asn Gln Asp
         195                 200                 205            
 Tyr Ile Arg Thr Phe Cys Ser Gln Gln Thr Glu Thr Ser Gly Gln Ile
     210                 215                 220                
 Gln Gly Val Ala Val Thr Ser Ser Ala Asp Val Glu Val Thr Asn Glu
 225                 230                 235                 240
 Lys Gln Gly Lys Lys Lys Ser Lys Thr Ala Val Asn Val Leu Leu Lys
                 245                 250                 255    
 Pro Asn Pro Leu Asp Gln Thr Cys Ile His Pro Glu Ser Tyr Asp Ile
             260                 265                 270        
 Ala Met Arg Phe Leu Ser Ser Ile Gly Gly Thr Leu Tyr Glu Val Gly
         275                 280                 285            
 Lys Pro Glu Met Gln Gln Lys Ile Asn Ser Phe Leu Glu Lys Glu Gly
     290                 295                 300                
 Met Glu Lys Ile Ala Glu Arg Leu Gln Thr Thr Val His Thr Leu Gln
 305                 310                 315                 320
 Val Ile Ile Asp Gly Leu Ser Gln Pro Glu Ser Phe Asp Phe Arg Thr
                 325                 330                 335    
 Asp Phe Asp Lys Pro Asp Phe Lys Arg Ser Ile Val Cys Leu Glu Asp
             340                 345                 350        
 Leu Gln Ile Gly Thr Val Leu Thr Gly Lys Val Glu Asn Ala Thr Leu
         355                 360                 365            
 Phe Gly Ile Phe Val Asp Ile Gly Val Gly Lys Ser Gly Leu Ile Pro
     370                 375                 380                
 Ile Arg Asn Val Thr Glu Ala Lys Leu Ser Lys Thr Lys Lys Arg Arg
 385                 390                 395                 400
 Ser Leu Gly Leu Gly Pro Gly Glu Arg Val Glu Val Gln Val Leu Asn
                 405                 410                 415    
 Ile Asp Ile Pro Arg Ser Arg Ile Thr Leu Asp Leu Ile Arg Val Leu
             420                 425                 430        





      <210> 1619
      <211> 320
      <212> PRT
      <213> Homo sapiens


      <400> 1619
 Met Thr Leu Gly Arg Arg Leu Ala Cys Leu Phe Leu Ala Cys Val Leu
   1               5                  10                  15    
 Pro Ala Leu Leu Leu Gly Gly Thr Ala Leu Ala Ser Glu Ile Val Gly
              20                  25                  30        
 Gly Arg Arg Ala Arg Pro His Ala Trp Pro Phe Met Val Ser Leu Gln
          35                  40                  45            
 Leu Arg Gly Gly His Phe Cys Gly Ala Thr Leu Ile Ala Pro Asn Phe
      50                  55                  60                
 Val Met Ser Ala Ala His Cys Val Ala Asn Val Asn Val Arg Ala Val
  65                  70                  75                  80
 Arg Val Val Leu Gly Ala His Asn Leu Ser Arg Arg Glu Pro Thr Arg
                  85                  90                  95    
 Gln Val Phe Ala Val Gln Arg Ile Phe Glu Asn Gly Tyr Asp Pro Val
             100                 105                 110        
 Asn Leu Leu Asn Asp Ile Val Ile Leu Gln Gly Gly Pro Asp Leu Leu
         115                 120                 125            
 Ser Ile Asn Lys Leu Thr Glu Lys Gly Gly Pro Asp Leu Leu Ser Ile
     130                 135                 140                
 Asn Lys Leu Thr Glu Lys Gly Gly Pro Asp Leu Leu Ser Ile Asn Lys
 145                 150                 155                 160
 Leu Thr Glu Lys Gly Gly Pro Asp Leu Leu Ser Ile Asn Lys Leu Thr
                 165                 170                 175    
 Glu Lys Gly Gly Pro Asp Leu Leu Ser Ile Asn Lys Leu Thr Glu Lys
             180                 185                 190        
 Gly Gly Pro Asp Leu Leu Ser Ile Asn Lys Leu Thr Glu Lys Gly Gly
         195                 200                 205            
 Pro Asp Leu Leu Ser Ile Asn Lys Leu Thr Glu Lys Gly Gly Pro Asp
     210                 215                 220                
 Leu Leu Ser Ile Asn Lys Leu Thr Glu Lys Gly Gly Pro Asp Leu Leu
 225                 230                 235                 240
 Ser Ile Asn Lys Leu Thr Glu Lys Gly Gly Pro Asp Leu Leu Ser Ile
                 245                 250                 255    
 Asn Lys Leu Thr Glu Ile Leu Cys Val Ser Pro Phe Thr Ser Pro Val
             260                 265                 270        
 Ala Gln Gly Arg Gly Arg Leu Cys Leu Trp Glu Lys Gly Gln Lys Ser
         275                 280                 285            
 Pro Pro Phe His Pro Cys Pro Arg Leu Ala Val Leu Val Ile Ser Trp
     290                 295                 300                
 Ala Pro Gly Pro Val Ala Gln Ala Cys His Pro Ser Thr Leu Gly Gly
 305                 310                 315                 320





      <210> 1620
      <211> 482
      <212> PRT
      <213> Homo sapiens


      <400> 1620
 Met Asn Arg Phe Lys Ser Gln Phe Cys Gln Leu Leu Ala Cys Ser Phe
   1               5                  10                  15    
 Gly Gln Leu Arg Tyr Lys Glu Ile Ser Thr Val Gly Arg Leu Gly Ser
              20                  25                  30        
 His Pro Gly Ile Glu Ala Ser Cys Ile Lys Asn Val Asn Val Cys Cys
          35                  40                  45            
 Lys Thr Thr Phe Arg Gly Ala Gln Ser Tyr Ser Phe Pro Pro Gly Arg
      50                  55                  60                
 Ile Lys Tyr Ser Glu Gln Val Tyr Asp Ala Cys Met Glu Thr Phe Asp
  65                  70                  75                  80
 Cys Leu Pro Leu Ala Ala Leu Leu Asn Gln Gln Phe Leu Cys Val His
                  85                  90                  95    
 Gly Gly Met Ser Pro Glu Ile Thr Ser Leu Asp Asp Ile Arg Lys Leu
             100                 105                 110        
 Asp Arg Phe Thr Glu Pro Pro Ala Phe Gly Pro Val Cys Asp Leu Leu
         115                 120                 125            
 Trp Ser Asp Pro Ser Glu Asp Tyr Gly Asn Glu Lys Thr Leu Glu His
     130                 135                 140                
 Tyr Thr His Asn Thr Val Arg Gly Cys Ser Tyr Phe Tyr Ser Tyr Pro
 145                 150                 155                 160
 Ala Val Cys Glu Phe Leu Gln Asn Asn Asn Leu Leu Ser Ile Ile Arg
                 165                 170                 175    
 Ala His Glu Ala Gln Asp Ala Gly Tyr Arg Met Tyr Arg Lys Ser Gln
             180                 185                 190        
 Ala Thr Gly Phe Pro Ser Leu Ile Thr Ile Phe Ser Ala Pro Asn Tyr
         195                 200                 205            
 Leu Asp Val Tyr Asn Asn Lys Ala Ala Val Leu Lys Tyr Glu Asn Asn
     210                 215                 220                
 Val Met Asn Ile Arg Gln Phe Asn Cys Ser Pro His Pro Tyr Trp Leu
 225                 230                 235                 240
 Pro Asn Phe Met Asp Val Phe Thr Trp Ser Leu Pro Phe Val Gly Glu
                 245                 250                 255    
 Lys Glu Met Leu Val Asn Val Leu Asn Ile Cys Ser Asp Asp Glu Leu
             260                 265                 270        
 Ile Ser Asp Asp Glu Ala Glu Gly Ser Thr Thr Val Arg Lys Glu Ile
         275                 280                 285            
 Ile Arg Asn Lys Ile Arg Ala Ile Gly Lys Met Ala Arg Val Phe Ser
     290                 295                 300                
 Ile Leu Arg Gln Glu Ser Glu Ser Val Leu Thr Leu Lys Gly Leu Thr
 305                 310                 315                 320
 Pro Thr Gly Thr Leu Pro Leu Gly Val Leu Ser Gly Gly Lys Gln Thr
                 325                 330                 335    
 Ile Glu Thr Ala Ile Arg Gly Phe Ser Leu Gln His Lys Ile Arg Ser
             340                 345                 350        
 Phe Glu Glu Ala Arg Gly Leu Asp Arg Ile Asn Glu Arg Met Pro Pro
         355                 360                 365            
 Arg Lys Asp Ser Ile His Ala Asp Glu Pro Arg His Ala Ile Val Ser
     370                 375                 380                
 Ile Gly Gly Pro Leu Lys Pro Gln Asn Gly Ser Phe Ala Leu Pro Ser
 385                 390                 395                 400
 Ser Ala Cys Ser Cys Ser His Glu Trp Leu Ala Trp Lys Gly Pro Ser
                 405                 410                 415    
 Val Glu Leu Gly Trp Gln His Leu Gln Glu Gln Glu Ser Thr Glu Asp
             420                 425                 430        
 Pro Gly Glu Arg Asp Gly Ala Gln Gly Met Lys His Ser Pro Asp Ser
         435                 440                 445            
 Cys Trp Tyr Val His Val Thr Trp Phe Gln Phe Leu Thr Ile Val Ser
     450                 455                 460                
 Leu Trp Pro Ser Arg Glu Val Gln Thr Ala Gly Asn Gly Gln Cys Phe
 465                 470                 475                 480
 Leu Arg
        



      <210> 1621
      <211> 156
      <212> PRT
      <213> Homo sapiens


      <400> 1621
 Met Ala Asp Ala Phe Ala Asn Val Val Met Leu Leu Val Ala Ala Gly
   1               5                  10                  15    
 Val Phe Ala Gln Gly Leu Ser Thr Ile Gly Phe Ile Gln Ser Leu Ile
              20                  25                  30        
 Ser Ile Ala Thr Ser Phe Gly Ser Ala Ser Ile Ile Leu Met Leu Val
          35                  40                  45            
 Leu Val Ile Leu Thr Met Leu Ala Ala Val Thr Thr Gly Ser Gly Asn
      50                  55                  60                
 Ala Pro Phe Tyr Ala Phe Val Glu Met Ile Pro Lys Leu Ala His Ser
  65                  70                  75                  80
 Ser Gly Ile Asn Pro Ala Tyr Leu Thr Ile Pro Met Leu Gln Ala Ser
                  85                  90                  95    
 Asn Leu Gly Arg Thr Leu Ser Pro Val Ser Gly Val Val Val Ala Val
             100                 105                 110        
 Ala Gly Met Ala Lys Ile Ser Pro Phe Glu Val Val Lys Arg Thr Ser
         115                 120                 125            
 Val Pro Val Leu Val Gly Leu Val Ile Val Ile Val Ala Thr Glu Leu
     130                 135                 140                
 Met Val Pro Gly Thr Ala Ala Ala Val Thr Gly Lys
 145                 150                 155    



      <210> 1622
      <211> 230
      <212> PRT
      <213> Homo sapiens


      <400> 1622
 Met Leu Gly Leu Arg Pro Gly Gly Ala Gly Gly Ser Thr Leu Val Pro
   1               5                  10                  15    
 Ala Val Phe Ala Leu Leu Asp Pro Leu Gly Pro Ser Leu Gln Ser Arg
              20                  25                  30        
 Lys Ala Ala Val Thr Val Val Gly Gly Trp Gln Ser Ile Gln Pro Gln
          35                  40                  45            
 Thr Thr Leu Thr Arg Ala Pro Gln Pro His Pro Ala Asp Gly Phe Tyr
      50                  55                  60                
 Cys Leu Thr Phe Ser Phe Leu Gly His Thr Leu Ser Ser Gln Leu His
  65                  70                  75                  80
 Gln Leu Glu Gln Met Leu Leu Asn Thr Ser Phe Pro Gly Tyr Asn Leu
                  85                  90                  95    
 Thr Leu Gln Thr Pro Thr Ile Gln Ser Leu Ala Phe Lys Leu Ser Cys
             100                 105                 110        
 Asp Phe Ser Gly Leu Ser Leu Thr Ser Ala Thr Leu Lys Arg Val Pro
         115                 120                 125            
 Gln Ser Asp Gly Tyr Arg Ile Leu Val Asp Arg Leu Trp Pro Arg Gly
     130                 135                 140                
 Ile Lys Lys Thr Asp Leu Ala Leu Asp Glu Trp Asp Lys Glu Ile Thr
 145                 150                 155                 160
 Pro Ser Thr Glu Leu Arg Lys Ala Phe His Gly Glu Val Val Asp Tyr
                 165                 170                 175    
 Ala Thr Phe Arg Glu Gln Tyr Leu Ala Glu Leu Ala Gln His Glu Gln
             180                 185                 190        
 Glu Gly Lys Arg Leu Ala Asp Ile Ala Lys Lys Gln Pro Leu Thr Leu
         195                 200                 205            
 Leu Tyr Ser Ala Lys Asn Thr Thr Gln Asn His Ala Leu Val Leu Ala
     210                 215                 220                
 Asp Trp Leu Arg Ser Leu
 225                 230



      <210> 1623
      <211> 268
      <212> PRT
      <213> Homo sapiens

      <220>
      <221> misc_feature
      <222> (1)...(268)
      <223> Xaa = any amino acid or nothing 


      <400> 1623
 Met Arg Phe Pro Ser Ser Gly Ala Pro Leu Phe Gly Leu Leu Tyr Asp
   1               5                  10                  15    
 Leu Trp Arg Ser Arg Phe Ser Gly Val Val Asn Pro Arg Thr Ile Ser
              20                  25                  30        
 Gly Ser Asn Thr Val Pro Ser Thr Gln Val Ala Asp Ala Arg Ile Glu
          35                  40                  45            
 Tyr Val Gly Asn Gly Tyr Ile Asn Glu Ala Gln Asn Met Gly Trp Leu
      50                  55                  60                
 Gln Arg Phe Phe Leu Asn Leu Ser Pro Met Ser Leu Arg Cys Gly Asn
  65                  70                  75                  80
 Ser Val Gln Val Asn Gln Leu Asn Gly Gly Arg Ile Thr Asn Gly Ala
                  85                  90                  95    
 Val Ile Glu Arg Glu Leu Pro Ser Gln Phe Gly Val Gly Asn Thr Leu
             100                 105                 110        
 Asn Leu Gln Leu Asn Asp Glu Asp Phe Ser Met Ala Gln Gln Ile Ala
         115                 120                 125            
 Asp Thr Ile Asn Arg Val Arg Gly Tyr Gly Ser Ala Thr Ala Leu Asp
     130                 135                 140                
 Ala Arg Thr Ile Gln Val Arg Val Pro Ser Gly Asn Ser Ser Gln Val
 145                 150                 155                 160
 Arg Phe Leu Ala Asp Ile Gln Asn Met Gln Val Asn Val Thr Pro Gln
                 165                 170                 175    
 Xaa Ala Xaa Val Val Ile Asn Ser Arg Thr Gly Ser Val Val Met Asn
             180                 185                 190        
 Arg Glu Val Thr Leu Asp Ser Cys Ala Val Ala Gln Gly Asn Leu Ser
         195                 200                 205            
 Val Thr Val Asn Arg Gln Ala Asn Val Ser Gln Pro Asp Thr Pro Phe
     210                 215                 220                
 Gly Gly Gly Gln Thr Val Val Leu Thr Asn Ala Asp His Leu Arg Arg
 225                 230                 235                 240
 Arg Arg Phe Gly Ala Lys Gln Pro Phe Val Arg Val Asn Ser Asn Ile
                 245                 250                 255    
 Gly Cys Tyr Gly Asn Ser Gln Asn Val Asn Ala Asn
             260                 265            



      <210> 1624
      <211> 192
      <212> PRT
      <213> Homo sapiens

      <220>
      <221> misc_feature
      <222> (1)...(192)
      <223> Xaa = any amino acid or nothing 


      <400> 1624
 Met Lys Leu Gly Val Val Gly Phe Thr Cys Phe Val Ala Thr Cys Ala
   1               5                  10                  15    
 Ile Arg Gly Ile Ala Thr Asp Phe Ser Asp Val Asn Asp Trp Gln Phe
              20                  25                  30        
 Phe Lys Gly Ala Gln Lys Leu Gly Glu Leu Gly Gln Pro Gly Ala Gly
          35                  40                  45            
 Ala Leu Arg Lys Arg Ala Asp Arg Ser Glu Ala Ile Arg Arg Val Leu
      50                  55                  60                
 Tyr Leu Ala Lys Val Ala Gly Cys Arg Leu His Val Cys His Val Ser
  65                  70                  75                  80
 Ser Pro Glu Gly Val Glu Glu Val Thr Arg Ala Arg Gln Glu Gly Gln
                  85                  90                  95    
 Asp Val Thr Cys Glu Ser Cys Pro His Tyr Phe Val Leu Asp Thr Asp
             100                 105                 110        
 Gln Phe Glu Glu Ile Gly Thr Ala Ala Asp Ile Phe Gly Leu Gln Gln
         115                 120                 125            
 Lys Gly Arg Ile Ala Pro Gly Lys Asp Ala Asp Phe Val Phe Ile Gln
     130                 135                 140                
 Pro Asn Ser Ser Tyr Val Leu Thr Asn Asp Asp Leu Glu Tyr Arg His
 145                 150                 155                 160
 Lys Val Ser Pro Tyr Val Gly Arg Thr Ile Gly Ala Arg Ile Thr Lys
                 165                 170                 175    
 Thr Ile Leu Leu Arg Xaa Lys Gly Gln Phe Ile Leu Lys His Gln Gln
             180                 185                 190        





      <210> 1625
      <211> 573
      <212> PRT
      <213> Homo sapiens


      <400> 1625
 Met Phe Val Val Trp Arg Arg Gln Asn Pro Gly Ile Ser Trp Leu Leu
   1               5                  10                  15    
 Ala Ala Cys Ser Gln Arg Asp Phe Asp Ala Ile Arg Pro Val Phe Phe
              20                  25                  30        
 Ser Thr Ser Gln Leu Gly Gln Ala Ala Pro Ser Phe Gly Gly Thr Thr
          35                  40                  45            
 Gly Thr Leu Gln Asp Ala Phe Asp Leu Glu Ala Leu Lys Ala Leu Asp
      50                  55                  60                
 Ile Ile Val Thr Cys Gln Gly Gly Asp Tyr Thr Asn Glu Ile Tyr Pro
  65                  70                  75                  80
 Lys Leu Arg Glu Ser Gly Trp Gln Gly Tyr Trp Ile Asp Ala Ala Ser
                  85                  90                  95    
 Ser Leu Arg Met Lys Asp Asp Ala Ile Ile Ile Leu Asp Pro Val Asn
             100                 105                 110        
 Gln Asp Val Ile Thr Asp Gly Leu Asn Asn Gly Ile Arg Thr Phe Val
         115                 120                 125            
 Gly Gly Asn Cys Thr Val Ser Leu Met Leu Met Ser Leu Gly Gly Leu
     130                 135                 140                
 Phe Ala Asn Asp Leu Val Asp Trp Val Ser Val Ala Thr Tyr Gln Ala
 145                 150                 155                 160
 Ala Cys Gly Gly Gly Ala Arg His Met Arg Glu Leu Leu Thr Gln Met
                 165                 170                 175    
 Gly His Leu Tyr Gly His Val Ala Asp Glu Leu Ala Thr Pro Ser Ser
             180                 185                 190        
 Ala Ile Leu Asp Ile Glu Arg Lys Val Thr Thr Leu Thr Arg Ser Gly
         195                 200                 205            
 Glu Leu Pro Val Asp Asn Phe Gly Val Pro Leu Ala Gly Ser Leu Ile
     210                 215                 220                
 Pro Trp Ile Asp Lys Gln Leu Asp Asn Cys His Ser Arg Glu Glu Trp
 225                 230                 235                 240
 Lys Gly Gln Ala Glu Thr Asn Lys Ile Leu Asn Thr Ser Ser Val Ile
                 245                 250                 255    
 Pro Val Asp Gly Leu Cys Val Arg Val Gly Ala Leu Arg Cys His Ser
             260                 265                 270        
 Gln Ala Phe Thr Ile Lys Leu Lys Lys Asp Val Ser Ile Pro Thr Val
         275                 280                 285            
 Glu Glu Leu Leu Ala Ala His Asn Pro Trp Ala Lys Val Val Pro Asn
     290                 295                 300                
 Asp Arg Glu Ile Leu Cys Ala Ala Ser Asp Val Arg Asp Glu Phe Val
 305                 310                 315                 320
 Ser Val Thr Glu Lys Leu Met Asp Glu Leu Ala Gln Cys Tyr Asn Val
                 325                 330                 335    
 Leu Pro Gln Leu Asp Ile Asn Asn Thr Ile Asp His Arg Pro Glu Gly
             340                 345                 350        
 Asp Glu Lys Trp Phe Leu Glu Asn Glu Lys Thr Val Thr Gln Phe Cys
         355                 360                 365            
 Arg Lys Leu Ala Ala Glu Arg Pro Leu Lys Asp Ile Arg Asp Glu Tyr
     370                 375                 380                
 Asn Tyr Pro Lys Lys Lys Val Ser Pro Tyr Tyr Arg Thr Lys Leu Arg
 385                 390                 395                 400
 Gly Leu Tyr Thr Thr Ala Lys Ala Asp Ala Glu Ala Glu Cys Asn Ile
                 405                 410                 415    
 Leu Arg Lys Ala Leu Asp Lys Ile Ala Glu Ile Lys Ser Leu Leu Glu
             420                 425                 430        
 Glu Arg Arg Ile Ala Thr Gln Glu Ala Glu Val Glu Lys Pro Pro Lys
         435                 440                 445            
 Pro Lys Lys Trp Arg Val Asp Glu Val Glu Gln Ser Pro Lys Pro Lys
     450                 455                 460                
 Arg Gln Arg Glu Ala Glu Ala Gln Gln Leu Pro Lys Pro Lys Arg Arg
 465                 470                 475                 480
 Arg Leu Thr Thr Ser Ala Pro Gln Gln Pro Pro Gly Pro Glu Asp Glu
                 485                 490                 495    
 Asp Ser Ser Leu Asp Glu Ser Asp Leu Tyr Ser Leu Ala His Ser Tyr
             500                 505                 510        
 Leu Gly Pro Leu Ile Met Pro Met Pro Thr Ser Pro Leu Thr Pro Ala
         515                 520                 525            
 Leu Val Thr Gly Gly Gly Gly Arg Lys Gly Arg Thr Lys Arg Glu Ala
     530                 535                 540                
 Ala Ala Asn Thr Asn Arg Pro Ser Pro Gly Gly His Glu Arg Lys Leu
 545                 550                 555                 560
 Val Thr Lys Leu Gln Leu Ala Cys Ser Leu Arg Ser Ile
                 565                 570            



      <210> 1626
      <211> 177
      <212> PRT
      <213> Homo sapiens


      <400> 1626
 Met Ser Leu Arg Ser Leu Ser Phe Thr Ile Pro Leu Tyr Leu Gly Phe
   1               5                  10                  15    
 Gly Tyr Asp Phe Glu Leu Gly Thr Pro Leu His Pro Gly Gln Ser Ala
              20                  25                  30        
 Ala Ile Tyr Leu Lys Gly Glu Arg Ile Gly Phe Val Gly Val Val His
          35                  40                  45            
 Pro Glu Leu Glu Arg Lys Leu Asp Leu Asn Gly Arg Thr Leu Val Phe
      50                  55                  60                
 Glu Leu Glu Trp Asn Lys Leu Ala Tyr Arg Val Val Pro Gln Ala Arg
  65                  70                  75                  80
 Glu Ile Ser Arg Phe Pro Ala Asn Arg Arg Asp Ile Ala Val Val Val
                  85                  90                  95    
 Ala Glu Asn Val Pro Ala Ala Asp Ile Leu Ser Glu Cys Lys Lys Val
             100                 105                 110        
 Gly Val Asn Gln Val Val Gly Val Asn Leu Phe Asp Met Tyr Arg Gly
         115                 120                 125            
 Lys Gly Val Ala Glu Gly Tyr Lys Ser Leu Ala Ile Ser Leu Ile Leu
     130                 135                 140                
 Gln Asp Thr Ser Arg Thr Leu Glu Glu Glu Glu Ile Ala Ala Thr Val
 145                 150                 155                 160
 Ala Lys Cys Val Glu Ala Leu Lys Glu Arg Ser Gln Ala Ser Leu Arg
                 165                 170                 175    
 Asn
    



      <210> 1627
      <211> 168
      <212> PRT
      <213> Homo sapiens


      <400> 1627
 Met Ile Leu Ala Leu Ile Ala Phe Ile Cys Ile Glu Thr Ile Met Ala
   1               5                  10                  15    
 Cys Ser Pro Cys Glu Gly Leu Tyr Phe Phe Glu Phe Val Ser Cys Ser
              20                  25                  30        
 Ala Phe Val Val Thr Gly Val Leu Leu Ile Met Phe Ser Leu Asn Leu
          35                  40                  45            
 His Met Arg Ile Pro Gln Ile Asn Trp Asn Leu Thr Gly Gln Gly Gln
      50                  55                  60                
 Gly Gln His Leu Val His Cys Tyr Pro Thr Cys Leu Val Phe Leu Arg
  65                  70                  75                  80
 Pro Val Asn Lys Tyr Leu Leu Ser Lys Gly Leu Gly Cys Glu Thr Leu
                  85                  90                  95    
 Arg Glu Asp Leu Phe Asp Lys Glu Ala Ala Ala Gly Lys Val Lys Thr
             100                 105                 110        
 Ile Gly Ile Glu Ser Asp Arg Pro Ser Trp Val Gln Val Gln Asp Gly
         115                 120                 125            
 Asn Asn Gln Pro Leu Ala Leu Leu Asn Ile His Leu Pro Val Met Met
     130                 135                 140                
 Leu Arg Ile Ala His Gly Pro Met Asp Thr Arg Tyr Pro Pro Glu Ile
 145                 150                 155                 160
 Asn Gly Leu Ser Lys Lys Thr Ala
                 165            



      <210> 1628
      <211> 353
      <212> PRT
      <213> Homo sapiens

      <220>
      <221> misc_feature
      <222> (1)...(353)
      <223> Xaa = any amino acid or nothing 


      <400> 1628
 Met Ile Ile Phe Pro Leu Leu Asn Asp Leu Arg Val Phe Met Leu Val
   1               5                  10                  15    
 Ala Pro Arg Ala Gly Phe Pro Pro Val Pro Glu Glu Leu Gly Val Ser
              20                  25                  30        
 Pro Ala Phe Val Ser Lys Arg Ile Ala Leu Leu Glu Gln Thr Leu Asn
          35                  40                  45            
 Val Val Leu Leu His Arg Thr Thr Arg Arg Val Thr Ile Thr Glu Glu
      50                  55                  60                
 Gly Glu Arg Ile Tyr Glu Trp Ala Gln Arg Ile Leu Gln Asp Val Gly
  65                  70                  75                  80
 Gln Met Met Asp Glu Leu Ser Asp Val Arg Gln Val Pro Gln Gly Met
                  85                  90                  95    
 Leu Arg Ile Ile Ser Ser Phe Gly Phe Gly Arg Gln Val Val Ala Pro
             100                 105                 110        
 Ala Leu Leu Ala Leu Ala Lys Ala Tyr Pro Gln Leu Glu Leu Arg Phe
         115                 120                 125            
 Asp Val Glu Asp Arg Leu Val Asp Leu Val Asn Glu Gly Val Asp Leu
     130                 135                 140                
 Asp Ile Arg Ile Gly Asp Asp Ile Ala Pro Asn Leu Ile Ala Arg Lys
 145                 150                 155                 160
 Leu Ala Thr Asn Tyr Arg Ile Leu Cys Ala Ser Pro Glu Phe Ile Ala
                 165                 170                 175    
 Gln His Gly Ala Pro Lys His Leu Thr Asp Leu Ser Ala Leu Pro Cys
             180                 185                 190        
 Leu Val Ile Lys Glu Arg Asp His Pro Phe Gly Val Trp Xaa Xaa Arg
         195                 200                 205            
 His Thr Gly Gly Pro Xaa Gly Arg Lys Lys Ile Ala Asn Pro Phe Ala
     210                 215                 220                
 Thr Asn Trp Ala Arg Ala Asn Met Ala His Phe Leu Gly Lys Gly Asp
 225                 230                 235                 240
 Lys Arg Phe Gln Gln Ala Gln Asn Gly Ile Leu Ala Ala Ile Glu Glu
                 245                 250                 255    
 Asp Asp Lys Asp Leu Glu Leu Thr Ile Asp Cys His Gly Glu Glu Met
             260                 265                 270        
 Ile Gly Asp Leu Asp Lys Asn Ser Phe Gly Ala Val Gly Leu Cys Ile
         275                 280                 285            
 Gly Glu Arg Val Gly Gly Pro Gly Cys Cys Glu Val Leu Ile Arg Met
     290                 295                 300                
 Thr Pro Thr Glu Asp Val Gly Glu Glu Arg Ser Asp Met Val Leu Tyr
 305                 310                 315                 320
 Ala Gly Lys Met Gly Met Thr Leu Glu Asp Pro Arg Xaa Pro Xaa Asp
                 325                 330                 335    
 Asp Tyr Arg Asp Arg His Arg Tyr Arg Arg Lys Pro Pro Val Phe Lys
             340                 345                 350        
 His
    



      <210> 1629
      <211> 108
      <212> PRT
      <213> Homo sapiens

      <220>
      <221> misc_feature
      <222> (1)...(108)
      <223> Xaa = any amino acid or nothing 


      <400> 1629
 Met Val Val Gly Val Gly Tyr Ser Ile Leu Asn Gln Leu Pro Gln Phe
   1               5                  10                  15    
 Asn Met Pro Gln Tyr Phe Ala His Gly Ala Val Leu Ser Ile Phe Val
              20                  25                  30        
 Gly Ala Ile Leu Trp Leu Ala Gly Ala Arg Val Gly Gly His Glu Gln
          35                  40                  45            
 Val Cys Asp Arg Tyr Cys Ala Ser His Ser Ala Gln Trp Leu Glu Phe
      50                  55                  60                
 His Val Ala His Ala Gln Phe Thr Ser Leu Gly Gln Thr Leu His Lys
  65                  70                  75                  80
 Thr Leu Glu Arg Ile Lys Thr Thr Ser Ile Lys Tyr Arg Asn Gly Ile
                  85                  90                  95    
 Pro Leu Gln Asn His Asn Xaa Val Cys Phe Lys Thr
             100                 105            



      <210> 1630
      <211> 127
      <212> PRT
      <213> Homo sapiens


      <400> 1630
 Met Glu Gly Ser Arg Met Lys Tyr Arg Ile Ala Leu Ala Val Ser Leu
   1               5                  10                  15    
 Phe Ala Leu Ser Ala Gly Ser Tyr Ala Thr Thr Leu Cys Gln Glu Lys
              20                  25                  30        
 Glu Gln Asn Ile Leu Lys Glu Ile Ser Tyr Ala Glu Lys His Gln Asn
          35                  40                  45            
 Gln Asn Arg Ile Asp Gly Leu Asn Lys Ala Leu Ser Glu Val Arg Ala
      50                  55                  60                
 Asn Cys Ser Asp Ser Gln Leu Arg Ala Asp His Gln Lys Lys Ile Ala
  65                  70                  75                  80
 Lys Gln Lys Asp Glu Val Ala Glu Arg Gln Gln Asp Leu Ala Glu Ala
                  85                  90                  95    
 Lys Gln Lys Gly Asp Ala Asp Lys Ile Ala Lys Arg Glu Arg Lys Leu
             100                 105                 110        
 Ala Glu Ala Gln Glu Glu Leu Lys Lys Leu Glu Ala Arg Asp Tyr
         115                 120                 125        



      <210> 1631
      <211> 174
      <212> PRT
      <213> Homo sapiens


      <400> 1631
 Met Pro Arg Ser Leu Glu Leu Leu Val Ile Val Val Thr Gly Ser Val
   1               5                  10                  15    
 Thr Ser Gln Val Lys Asn Ala Asp Tyr Leu Ile Leu Asp Pro Val Asn
              20                  25                  30        
 Asn Gln Val Tyr Val Asn Pro Thr Asn Glu Val Ile Asp Lys Met Arg
          35                  40                  45            
 Ala Val Gln Glu Gln Val Ala Ser Glu Lys Ala Glu Leu Ala Lys Leu
      50                  55                  60                
 Lys Asp Leu Pro Ala Ile Thr Leu Asp Gly His Gln Val Glu Val Cys
  65                  70                  75                  80
 Ala Asn Ile Gly Thr Val Arg Asp Val Glu Gly Ala Glu Arg Asn Gly
                  85                  90                  95    
 Ala Glu Gly Val Gly Leu Tyr Arg Thr Glu Phe Leu Phe Met Asp Arg
             100                 105                 110        
 Asp Ala Leu Pro Thr Glu Glu Glu Gln Phe Ala Ala Tyr Lys Ala Val
         115                 120                 125            
 Ala Glu Ala Cys Gly Ser Gln Ala Val Ile Val Arg Thr Met Asp Ile
     130                 135                 140                
 Gly Gly Asp Lys Glu Leu Pro Tyr Met Asn Phe Pro Lys Glu Glu Asn
 145                 150                 155                 160
 Pro Phe Leu Glu Leu Ala Arg Tyr Pro Tyr Arg Asp Gly Ser
                 165                 170                



      <210> 1632
      <211> 625
      <212> PRT
      <213> Homo sapiens


      <400> 1632
 Met Ser His Leu Ile His Arg Leu Leu Ile Leu Ala Ala Ile Trp Asn
   1               5                  10                  15    
 Asp Gln Thr Val Ala Ala Asp Asn Arg Ile Ala Trp Phe Glu Ala Arg
              20                  25                  30        
 Thr Ile Ala Gly Tyr Pro Val Leu Val Ser Glu Glu Asn Gly Val Val
          35                  40                  45            
 Thr Gly Tyr Ala Ser Tyr Gly Glu Trp Arg Asn Thr Met Arg Ile Gly
      50                  55                  60                
 Asn Val Asn Val Ala Thr Gly Glu Leu Gln Ala Thr Gly Gly Thr Phe
  65                  70                  75                  80
 Thr Asn Asn Phe Tyr Arg Tyr Pro Phe Glu Val Arg Phe Ile Ala Trp
                  85                  90                  95    
 Ile Ser Arg Lys Ser Ser Arg Ile Asp Val Val Val Gly Gly Ala Ser
             100                 105                 110        
 Arg Glu Asp Ala Gln Phe Ile Thr Trp Glu His Pro Leu Ile Arg Asn
         115                 120                 125            
 Gly Val Thr Val Asn Arg Val Lys Leu Ala Val Lys Gly Phe Lys Leu
     130                 135                 140                
 Tyr Leu Arg Arg Gln Ile Leu Ser Ser Thr Gly Glu Leu Arg Ser Thr
 145                 150                 155                 160
 Ser Ile Thr Phe Gln Thr Asn Tyr Ala Leu Ile Ala Phe Ala Phe Ala
                 165                 170                 175    
 Arg Gly Asn Gly Asp His His Val Thr Ile Ala Asp Met Glu Leu Leu
             180                 185                 190        
 Asp Asn Gly Asn Leu Gly His Glu Lys Leu Thr Gln Ala Arg Asn Glu
         195                 200                 205            
 Leu Leu Ser Leu Ala Ala Gln Ser Pro Asn Gln Val Thr Gly Val Arg
     210                 215                 220                
 Pro Asn Gly Leu Glu Asp Thr Pro Met Phe Lys Val Asn Val Asn Ala
 225                 230                 235                 240
 Ala Lys Ala Glu Ala Met Gly Val Ala Leu Ser Asp Ile Asn His Ile
                 245                 250                 255    
 Leu Ile Asn Pro Leu Ala Ala Asn Gly Glu Gly Thr Tyr Leu Asn Val
             260                 265                 270        
 Phe Thr Val His Phe His Ala Thr Asp Lys Val Leu Lys Asp Asp Asn
         275                 280                 285            
 Leu Leu Ala Leu Phe Asp Ile Pro Lys Ile Leu Trp Pro Pro Pro Ala
     290                 295                 300                
 Gln Cys Arg Tyr Pro Ala Lys Asn Asp Ala Ser Arg Leu Ser Arg Gln
 305                 310                 315                 320
 Tyr Leu Ser Tyr Ser Asp Arg Gln Ala Leu Phe Arg Gly Cys Thr Ile
                 325                 330                 335    
 Tyr Arg Ile His Ser Ile His Val Arg Ala Asn Thr Arg Thr Trp Ser
             340                 345                 350        
 Ala Cys Glu Thr Gln Arg Lys Arg Cys Val Leu Thr Pro Phe Pro Pro
         355                 360                 365            
 Arg Gln Ala Tyr Ile Ser Ser Arg Ile Pro Ser Ser Val Gly Ala Glu
     370                 375                 380                
 Gly Asp His Ile Gly Gly Phe Thr His Gly Val Leu Pro Gln Arg Pro
 385                 390                 395                 400
 Ala Leu Val Asn Leu Gln Cys Asp Ile Asp His Pro Thr Gln Ser Met
                 405                 410                 415    
 Ala Asp Leu Ala Trp Leu Arg Glu His Phe Gly Ser Leu Glu Asn Leu
             420                 425                 430        
 Lys Gly Lys Lys Ile Ala Met Thr Trp Ala Tyr Ser Pro Ser Tyr Gly
         435                 440                 445            
 Lys Pro Leu Ser Val Pro Gln Gly Ile Ile Gly Leu Met Thr Arg Phe
     450                 455                 460                
 Gly Met Asp Val Thr Leu Ala His Pro Glu Gly Tyr Asp Leu Ile Pro
 465                 470                 475                 480
 Asp Val Val Glu Val Ala Lys Asn Asn Ala Lys Ala Ser Gly Gly Ser
                 485                 490                 495    
 Phe Arg Gln Val Thr Ser Met Glu Glu Ala Phe Lys Asp Ala Asp Ile
             500                 505                 510        
 Val Tyr Pro Lys Ser Trp Ala Pro Tyr Lys Val Met Glu Glu Arg Thr
         515                 520                 525            
 Glu Leu Leu Arg Ala Asn Asp His Glu Gly Val Lys Arg Thr Gly Lys
     530                 535                 540                
 Thr Leu Ser Arg His Arg Thr Arg Asn Thr Asn Asp Trp His Gln His
 545                 550                 555                 560
 Arg Arg Asp Asp Gly Thr Asp Pro Val Arg Ala Lys Pro Arg Thr Ser
                 565                 570                 575    
 Thr Ala Asp Gln Thr Glu Ile Asn Gly Ala Ser Cys Lys Glu Gly Arg
             580                 585                 590        
 Ser Asp Gln Lys Ala Tyr Asp Glu Lys Ser Arg Val Ser Arg Pro Thr
         595                 600                 605            
 Asn Lys Pro Ala Gly Ser Leu Lys Ser Ile Ala Ala Arg Ile Leu Ser
     610                 615                 620                
 Arg
 625



      <210> 1633
      <211> 444
      <212> PRT
      <213> Homo sapiens


      <400> 1633
 Met Gly Val Gly Gly Leu Ala Gly Ala Cys Met Leu Arg Gly Leu Ser
   1               5                  10                  15    
 Ala Gly Gly Leu Thr Glu Arg Arg Arg Met Lys Arg Arg Tyr Pro Gln
              20                  25                  30        
 His Glu Ala Ser Ala Ala Gln Thr Gln Ala Leu Pro Pro Leu Val Ala
          35                  40                  45            
 Val Ser Trp Gly Leu Leu Ser Thr Pro Gly Pro Arg Met Cys Leu Leu
      50                  55                  60                
 Val Pro Glu Arg Ala Ala Ala Arg Ser Ser Pro Tyr Phe Glu Asp Met
  65                  70                  75                  80
 Lys Gly Ala Arg Thr Glu Gly Gly Ser Cys Arg Ala Thr Gly Ala Ser
                  85                  90                  95    
 His Trp His Gln Gly Leu Gly Leu Ala Val Ser Val Arg Ala Ser Trp
             100                 105                 110        
 Lys Arg Gln Gly Ser Pro Asn Arg His Gln Leu Pro Cys Pro Ala Ser
         115                 120                 125            
 Gly Leu Gln Asp Asp Leu Arg Gln His Leu Asp Lys Ser Leu Glu Glu
     130                 135                 140                
 Asn Ser Arg Leu Lys Ser Leu Leu Leu Ser Met Lys Lys Glu Val Lys
 145                 150                 155                 160
 Ser Ala Asp Thr Ala Ala Thr Leu Asn Leu Gln Ile Ala Gly Arg Leu
                 165                 170                 175    
 Cys Phe Lys Phe Phe Thr Glu Gly Ser Glu Gln Gln Gln Thr Gln Leu
             180                 185                 190        
 His Gly Asp Trp Lys Val Leu Lys Leu Cys Arg Pro Ala Leu Pro Ser
         195                 200                 205            
 Phe Met Pro Tyr Val Asn Met Ser Ile Asp Ile Asp Phe Thr Arg Arg
     210                 215                 220                
 Gly Leu His Thr Val Asp Ala Pro Ala Ala Leu Leu Pro Cys Gly Thr
 225                 230                 235                 240
 Ser Asn Lys Cys Glu Glu Ala Val Trp Arg Asp Cys Gly Thr Glu Ala
                 245                 250                 255    
 Ala Pro Gly Ala Leu Arg Gln Asp Pro Gly Ala His Ala Asp Ala Ala
             260                 265                 270        
 Gly Glu Pro Gln Val Pro Ala Arg Glu Thr Trp Val Gly Pro Arg Gly
         275                 280                 285            
 Glu Glu Ala Gln Val Lys Val Gln Leu Gly Val Ile Leu Leu Glu His
     290                 295                 300                
 Cys Gly Leu Asp Val Asp Lys Ala Gly Cys Thr Ala Pro Lys His Gly
 305                 310                 315                 320
 Gly Ile Gly Leu Leu Pro Pro Gly Phe Met Leu Ala Ser Ser Ser Pro
                 325                 330                 335    
 Gly Leu Arg Leu Leu Cys Cys Pro Ser Glu Gln Gly Leu Gly Leu His
             340                 345                 350        
 Ser Gly Pro Val Ser Gly Val Pro Ile Ser Val Ala Asn Val Thr Glu
         355                 360                 365            
 Val Leu Ser Arg Thr Ser Lys Ala Ala Pro Arg Gly Gln Asp Ser Gly
     370                 375                 380                
 Trp Glu Gly Gly Gly Ser Ser Leu Val Ser Thr Asn Glu His Leu Leu
 385                 390                 395                 400
 Gln Glu Leu Ser Gln Val Arg Ala Gln His Arg Ala Glu Val Glu Gln
                 405                 410                 415    
 Met His Trp Ser Tyr Gln Glu Leu Lys Lys Thr Met Ala Leu Phe Pro
             420                 425                 430        
 His Ser Ser Ala Ser His Gly Gly Cys Gln Ala Cys
         435                 440                



      <210> 1634
      <211> 208
      <212> PRT
      <213> Homo sapiens


      <400> 1634
 Met Arg Pro Ala Ala Leu Arg Gly Ala Leu Leu Gly Cys Leu Cys Leu
   1               5                  10                  15    
 Ala Leu Leu Cys Leu Gly Gly Ala Asp Lys Arg Leu Arg Ala Ser Val
              20                  25                  30        
 Ser Arg Pro Phe Ser Leu Glu His Pro Glu Pro Gly His Cys Leu Asp
          35                  40                  45            
 Leu His Leu Arg Ala Tyr Pro Ala Arg Cys Val Lys Leu Thr Leu Ala
      50                  55                  60                
 Pro Gly Leu Leu Gly Gln Met Thr Asp Val Gly Ile Trp Ser Asp Leu
  65                  70                  75                  80
 Leu Pro Glu Met Arg Ala Tyr Trp Pro Asp Val Ile His Ser Phe Pro
                  85                  90                  95    
 Asn Arg Ser Arg Phe Trp Lys His Glu Trp Glu Lys His Gly Thr Cys
             100                 105                 110        
 Ala Ala Gln Val Asp Ala Leu Asn Ser Gln Lys Lys Tyr Phe Gly Arg
         115                 120                 125            
 Ser Leu Glu Leu Tyr Arg Glu Leu Asp Leu Asn Arg Gly Glu Arg Val
     130                 135                 140                
 Pro Thr Gln Phe Pro Arg Glu Leu Val Val Asn Arg Ser Leu Ala Pro
 145                 150                 155                 160
 Pro Pro Thr Pro Gly Phe Leu Ser Gly His Val Ile Ser Val His Thr
                 165                 170                 175    
 Ser Ser Pro Leu Pro Ser Ala Met Ser Gly Ser Phe Leu Arg Pro Leu
             180                 185                 190        
 Pro Glu Ala Glu Ser Gly Ser Met Leu Leu Gly Gln Pro Ala Asp Pro
         195                 200                 205            





      <210> 1635
      <211> 434
      <212> PRT
      <213> Homo sapiens


      <400> 1635
 Met Glu Cys Trp Cys Ser Leu Leu Leu Gly Trp Gly Leu Pro Pro Ala
   1               5                  10                  15    
 Gly Leu Leu Ala Val Arg Asn Pro Asn Phe His Glu Ala Gln Asp Thr
              20                  25                  30        
 Pro Arg Arg His His Thr Thr Gln Met Asp Ala Ser Lys Ile Ile Met
          35                  40                  45            
 Asp Trp Lys Trp Met Ala Gly Asp Ala Ser Lys Ile Ile Met Asp Trp
      50                  55                  60                
 Lys Trp Met Ala Gly Asp Ala Ser Lys Ile Ile Met Asp Trp Lys Trp
  65                  70                  75                  80
 Met Ala Gly Asp Ala Ser Val Lys Ala Thr Pro Arg Ala Lys Glu Gly
                  85                  90                  95    
 Arg Gln Pro Trp Asp Pro Leu Gln Ala Pro Gln Pro Gly Ser Val Leu
             100                 105                 110        
 Pro Thr Gly Pro Leu Asp Val Ser Met Ala Ala Thr Asn Leu Glu Asn
         115                 120                 125            
 Gln Leu His Ser Ala Gln Lys Asn Leu Leu Phe Leu Gln Arg Glu His
     130                 135                 140                
 Ala Ser Thr Leu Lys Gly Leu His Ser Glu Ile Arg Arg Leu Gln Gln
 145                 150                 155                 160
 His Cys Thr Asp Leu Thr Tyr Glu Leu Thr Val Lys Ser Ser Glu Gln
                 165                 170                 175    
 Thr Gly Asp Gly Thr Ser Lys Ser Ser Glu Leu Lys Lys Arg Cys Glu
             180                 185                 190        
 Glu Leu Glu Ala Gln Leu Lys Val Lys Glu Asn Glu Asn Ala Glu Leu
         195                 200                 205            
 Leu Lys Glu Leu Glu Gln Lys Asn Ala Met Ile Thr Val Leu Glu Asn
     210                 215                 220                
 Thr Ile Lys Glu Arg Glu Lys Lys Tyr Leu Glu Glu Leu Lys Ala Lys
 225                 230                 235                 240
 Ser His Lys Leu Thr Leu Leu Ser Ser Glu Leu Glu Gln Arg Ala Ser
                 245                 250                 255    
 Thr Ile Ala Tyr Leu Thr Ser Gln Leu His Ala Ala Lys Lys Lys Leu
             260                 265                 270        
 Met Ser Ser Ser Gly Thr Ser Asp Ala Ser Pro Ser Gly Ser Pro Val
         275                 280                 285            
 Leu Ala Ser Tyr Lys Pro Ala Pro Pro Lys Asp Lys Leu Pro Glu Thr
     290                 295                 300                
 Pro Arg Arg Arg Met Lys Lys Ser Leu Ser Ala Pro Leu His Pro Glu
 305                 310                 315                 320
 Phe Glu Glu Val Tyr Arg Phe Gly Ala Glu Ser Arg Lys Leu Leu Leu
                 325                 330                 335    
 Arg Glu Pro Val Asp Ala Met Pro Asp Pro Thr Pro Phe Leu Leu Ala
             340                 345                 350        
 Arg Glu Ser Ala Glu Val His Leu Ile Lys Glu Arg Pro Leu Val Ile
         355                 360                 365            
 Pro Pro Ile Ala Ser Asp Arg Ser Gly Glu Gln His Ser Pro Ala Arg
     370                 375                 380                
 Glu Lys Pro His Lys Ala His Val Gly Val Ala His Arg Ile His His
 385                 390                 395                 400
 Ala Thr Pro Pro Gln Ala Gln Pro Glu Val Lys Thr Leu Ala Val Asp
                 405                 410                 415    
 Gln Val Asn Gly Gly Lys Val Val Arg Lys His Ser Gly Thr Asp Arg
             420                 425                 430        
 Thr Val
        



      <210> 1636
      <211> 265
      <212> PRT
      <213> Homo sapiens


      <400> 1636
 Met His Leu Trp Pro Pro Glu Ile Leu Phe Leu Met Leu Leu Asp Phe
   1               5                  10                  15    
 Pro Phe Gln Ser Lys Arg Asp His Leu Leu Met Asn Val Lys Trp Tyr
              20                  25                  30        
 Tyr Arg Gln Ser Glu Val Pro Asp Ser Val Tyr Gln His Leu Val Gln
          35                  40                  45            
 Asp Arg His Asn Glu Asn Asp Ser Gly Arg Glu Leu Val Ile Thr Asp
      50                  55                  60                
 Pro Val Ile Lys Asn Arg Glu Leu Phe Ile Ser Asp Tyr Val Asp Thr
  65                  70                  75                  80
 Tyr His Ala Ala Ala Leu Arg Lys Ser Glu Pro Phe Ala Val Val Glu
                  85                  90                  95    
 Met Cys Val Glu Val Gln His Tyr Cys Ile Ala Val Ser Phe Glu Phe
             100                 105                 110        
 Leu Thr Leu Ala Ile Pro Tyr Leu Tyr Leu Ser Arg Gly Lys Cys Asn
         115                 120                 125            
 Ile Ser His Phe Ser Asp Ile Phe Ala Ala Arg Glu Phe Lys Ala Arg
     130                 135                 140                
 Val Asp Ser Phe Phe Tyr Ile Leu Gly Tyr Asn Pro Glu Thr Arg Ser
 145                 150                 155                 160
 Ala Asn Pro Thr Pro Val Val His Leu Gly Leu Ile Gly Gly Glu Lys
                 165                 170                 175    
 Asp Val Trp Asp Pro Glu Ile Ile Asp Val His Gly Asp His Arg Thr
             180                 185                 190        
 Ser Gly Lys Ala Leu Ala Val Gly Asn Arg Trp Lys Tyr Glu Gly Ala
         195                 200                 205            
 Arg Leu Gln Ile Val Cys Thr Ser Leu Gln Ala Gly Lys Arg Trp Ala
     210                 215                 220                
 Arg Lys Cys Gly Gly Arg Ser Glu Val Gln Val Gly Ser Gln His Gln
 225                 230                 235                 240
 Tyr Thr Gly Ser Pro Cys Ser Arg Glu Leu Gly Glu Lys Thr Arg Pro
                 245                 250                 255    
 Leu Ser Gly Met Pro Leu Ser Thr Glu
             260                 265



      <210> 1637
      <211> 217
      <212> PRT
      <213> Homo sapiens


      <400> 1637
 Met Arg Gln Asn Phe Val Ala Gln Phe Val Gln Leu Leu Lys Arg Trp
   1               5                  10                  15    
 Leu Cys Asp Ile Gln Ser Gly Thr Val Val Glu Lys Asn Trp Ala Leu
              20                  25                  30        
 Ser Val Asp Arg Cys Arg Leu Gln Thr Leu Gln Phe Leu Met His Leu
          35                  40                  45            
 Ile Asp Leu Pro Asn Ile Leu Leu Arg Cys Thr Gly Leu Ala Arg Ile
      50                  55                  60                
 Gln Lys Ala Val Val Asp Gln Thr Ser Ser Arg Pro Pro Lys Ser Asp
  65                  70                  75                  80
 Leu Gly Ser Phe Cys Ala Cys Thr Ser Ser Asn Asn Asn Thr Tyr Trp
                  85                  90                  95    
 Cys Leu Arg Thr Val Asn Glu Thr His Asn Phe Leu Phe Cys Glu Phe
             100                 105                 110        
 Ala Thr Gly Phe Leu Glu Tyr Phe Asp Met Asn Thr Asp Pro Tyr Gln
         115                 120                 125            
 Leu Thr Asn Thr Val His Thr Val Glu Arg Gly Ile Leu Asn Gln Leu
     130                 135                 140                
 His Val Gln Leu Met Glu Leu Arg Ser Cys Gln Gly Tyr Lys Gln Cys
 145                 150                 155                 160
 Asn Pro Arg Pro Lys Asn Leu Asp Val Glu Asn Phe Asp Gly Lys Thr
                 165                 170                 175    
 Gln Cys Ser Ile Ser Ala Val Pro Val Trp Ser Ser Pro Ser Trp Ile
             180                 185                 190        
 Pro Ala Tyr Asp Thr Glu Leu Asp Phe Phe Cys Gln Tyr Phe Ser Ser
         195                 200                 205            
 Glu Thr Arg Asp Ile Gly Ala Val His
     210                 215        



      <210> 1638
      <211> 179
      <212> PRT
      <213> Homo sapiens


      <400> 1638
 Met Lys Gly Pro Leu Val Trp Ala Gly Asp Leu Gly Gly Ser Phe Cys
   1               5                  10                  15    
 Ile Leu Ser Leu Thr Leu Leu Leu Ser Val Val Ser Ala Leu Glu Pro
              20                  25                  30        
 Lys Ala Val Trp Pro Glu Tyr Lys Glu Cys Phe Ser Leu Tyr Asp Lys
          35                  40                  45            
 Gln Gln Arg Gly Lys Ile Lys Ala Thr Asp Leu Met Val Ala Met Arg
      50                  55                  60                
 Cys Leu Gly Ala Ser Pro Thr Pro Gly Glu Val Gln Arg His Leu Gln
  65                  70                  75                  80
 Thr His Gly Ile Asp Gly Asn Gly Glu Leu Asp Phe Ser Thr Phe Leu
                  85                  90                  95    
 Thr Ile Met His Met Gln Ile Lys Gln Glu Asp Pro Lys Lys Glu Ile
             100                 105                 110        
 Leu Leu Ala Met Leu Met Val Asp Lys Glu Lys Lys Gly Tyr Val Met
         115                 120                 125            
 Ala Ser Asp Leu Arg Ser Lys Leu Thr Ser Leu Gly Glu Lys Leu Thr
     130                 135                 140                
 His Lys Glu Val Asp Asp Leu Phe Arg Glu Ala Asp Ile Glu Pro Asn
 145                 150                 155                 160
 Gly Lys Val Lys Tyr Asp Glu Phe Ile His Lys Ile Thr Leu Pro Gly
                 165                 170                 175    
 Arg Asp Tyr
            



      <210> 1639
      <211> 428
      <212> PRT
      <213> Homo sapiens


      <400> 1639
 Met Ala Gln Lys Gln Leu Arg Leu Thr Val Thr Phe Leu Thr Ser Tyr
   1               5                  10                  15    
 Phe Met Lys Met Leu Asn Leu Arg Phe Ser Pro Phe Phe Leu Ile Phe
              20                  25                  30        
 Ser Ser Asp Leu Val Gln Glu Leu Arg Leu Lys Val Leu Val Arg Phe
          35                  40                  45            
 Lys Asp Leu Glu Gly Val Ala Ser Gly Gly Gly Thr Gly Gly Ser Glu
      50                  55                  60                
 Met Thr Phe Thr Lys Phe Gln Gly Gln Arg Met Ala Gly Glu Gln Lys
  65                  70                  75                  80
 Pro Ser Ser Asn Leu Leu Glu Gln Phe Ile Leu Leu Ala Lys Gly Thr
                  85                  90                  95    
 Ser Gly Ser Ala Leu Thr Ala Leu Ile Ser Gln Val Leu Glu Ala Pro
             100                 105                 110        
 Gly Val Tyr Val Phe Gly Glu Leu Leu Glu Leu Ala Asn Val Gln Glu
         115                 120                 125            
 Leu Ala Glu Gly Ala Asn Ala Ala Tyr Leu Gln Leu Leu Asn Leu Phe
     130                 135                 140                
 Ala Tyr Gly Thr Tyr Pro Asp Tyr Ile Glu Ala Ala Val Gly Tyr Gly
 145                 150                 155                 160
 Ser Asn Thr Cys Ile Phe Ala Asn Ala Cys Gln Met Val Phe Ile Met
                 165                 170                 175    
 Ile Thr Trp Pro Tyr Leu Gln Cys Ile Pro Tyr Ser Val Leu Leu Lys
             180                 185                 190        
 Asp Leu Glu Met Arg Asn Leu Arg Glu Leu Glu Asp Leu Ile Ile Glu
         195                 200                 205            
 Ala Val Tyr Thr Asp Ile Ile Gln Gly Lys Leu Asp Gln Arg Asn Gln
     210                 215                 220                
 Leu Leu Glu Val Asp Phe Cys Ile Gly Arg Asp Ile Arg Lys Lys Asp
 225                 230                 235                 240
 Ile Asn Asn Ile Val Lys Thr Leu His Glu Trp Cys Asp Gly Cys Glu
                 245                 250                 255    
 Ala Val Leu Leu Gly Ile Glu Gln Gln Val Leu Arg Ala Asn Gln Tyr
             260                 265                 270        
 Lys Glu Asn His Asn Arg Thr Gln Gln Gln Val Glu Ala Glu Ala Tyr
         275                 280                 285            
 Leu Phe Ile Arg Leu Gln Cys Leu Cys Phe Cys Phe Ala Asn Leu Gly
     290                 295                 300                
 Val Asp Glu Thr Ser Ser His Gln Gln Asp Val Tyr Ile Leu Pro Gln
 305                 310                 315                 320
 Ser Gly Asn Asp Cys Arg Gly Leu Arg Phe Val Ser Ser Leu Ile Gly
                 325                 330                 335    
 Gly Val Arg Cys Val His Leu Lys His Lys Gly Asp Ala Val Val Trp
             340                 345                 350        
 Glu Ala Ile Glu Glu Gly Glu Ala Leu Pro Gly Lys Tyr Arg Leu Lys
         355                 360                 365            
 Gly Gly Arg Ser Val Trp Ala Ala Ala Val Arg Ala Val Cys Met Asp
     370                 375                 380                
 Gln Val Leu Asn Ser Pro Gly Arg Ile Arg Gly Ala Thr Trp Gly Gly
 385                 390                 395                 400
 Ala Val Thr Pro Gly Val His Glu Gln Gln Lys Gly Ile Gly Gly Met
                 405                 410                 415    
 Thr Ala Ser Lys Cys Gly Val Gly Asp Glu Cys Gly
             420                 425            



      <210> 1640
      <211> 299
      <212> PRT
      <213> Homo sapiens


      <400> 1640
 Met Ala Leu Lys Met Arg Arg Glu Ala Gly Trp Ala Val Cys Val Val
   1               5                  10                  15    
 Arg Arg Leu Ala Ala Ala Pro Ala Ala Ala Ala Ala Ala Ala Ala Ser
              20                  25                  30        
 Phe Leu His Asp Thr Ala Glu Pro Gln Leu Leu Gln Gln Phe Gln Ala
          35                  40                  45            
 Ile Arg Pro Gly Ser Ala Ala Thr Gly Thr Arg Glu Gly Pro Gly Ala
      50                  55                  60                
 Arg Glu Gln Asn Glu Ala Gln Ala Asp Gln Ala Glu Pro Glu Glu Arg
  65                  70                  75                  80
 Trp Gly Leu Ala Ala Glu Gly Met Gly Pro Glu Arg Arg Val Trp Arg
                  85                  90                  95    
 Arg Pro His Thr Gly Ser Thr His Ala Gln Thr Pro Arg Leu Pro Asp
             100                 105                 110        
 Ala Val Ala Pro Arg Ser Gly Leu Leu Gln Arg Gln Lys Pro Leu Arg
         115                 120                 125            
 Asp Ala Ser Arg Gly Ser Arg Trp Val Glu Gly Val Lys Lys Ala Ser
     130                 135                 140                
 Pro Pro Leu Pro Ala Glu Leu Ile Gly Trp Leu Val Asn Phe Pro Leu
 145                 150                 155                 160
 Ala Arg Pro Val Arg Pro Pro Ser Leu Ser Pro Gly Pro Pro Arg Arg
                 165                 170                 175    
 Pro Pro Glu Gly Val Cys Gly Ser Trp Pro Gly Arg Ser Glu Gly Glu
             180                 185                 190        
 Arg Gly Lys Ala Lys Asn Thr Ala Glu Ser Thr Pro Arg Gln Asn Leu
         195                 200                 205            
 His Arg Lys Tyr Thr Ile Ile Val Thr His Tyr Gln Arg Asn Arg Lys
     210                 215                 220                
 Gly Gln Asn Ile Ser Phe Ser Leu Val Cys Glu Phe His Pro Ser Leu
 225                 230                 235                 240
 Ala Asp Trp Thr Thr Val Thr Ala Leu Thr Trp Thr Ser Pro Lys Asp
                 245                 250                 255    
 Asn Ser Leu Thr Glu Glu Ser Trp Leu Arg Glu Gly Asn Val His Arg
             260                 265                 270        
 Gly Met Asp Glu Tyr Val Arg Ala Gln Ser Phe Leu Ile Leu Met Thr
         275                 280                 285            
 Leu Glu Asn Ser Gly Gly Ser Val Val Ser Lys
     290                 295                



      <210> 1641
      <211> 367
      <212> PRT
      <213> Homo sapiens


      <400> 1641
 Met Gln Leu Pro Leu Ala Leu Cys Leu Val Cys Leu Leu Val His Thr
   1               5                  10                  15    
 Ala Phe Arg Val Val Glu Gly Gln Gly Trp Gln Ala Phe Lys Asn Asp
              20                  25                  30        
 Ala Thr Glu Ile Ile Pro Glu Leu Gly Glu Tyr Pro Glu Pro Pro Pro
          35                  40                  45            
 Glu Leu Glu Asn Asn Lys Thr Met Asn Arg Ala Glu Asn Gly Gly Arg
      50                  55                  60                
 Pro Pro His His Pro Phe Glu Thr Lys Ala Leu Val Glu Glu Gln Ser
  65                  70                  75                  80
 Cys Leu Glu Val Gly Glu Glu Trp Leu Ala Gly Ala Ala Phe Lys Phe
                  85                  90                  95    
 Arg Cys Arg Gly Met Arg Gln Gln Thr Leu Val Arg Ala Gln Gly Arg
             100                 105                 110        
 Glu Asp Ala Gly Val Val Arg Val Trp His Gln Gly Ile Arg Thr Gly
         115                 120                 125            
 Ser Gly Ala Gln Lys Arg Lys Gly Phe Lys Glu Ser Pro Pro Gly Asn
     130                 135                 140                
 Ile Gly Ala Thr Ser Ser Cys Trp Tyr His Trp Glu Gly Asn Lys Val
 145                 150                 155                 160
 Ala Glu Lys Ser Thr Ala Gln Ala Pro Gly Pro Gln Pro Ser Pro Pro
                 165                 170                 175    
 His Asn Leu Leu Gly Leu Trp Gly Ala Lys Lys Gly Asn Cys Met Gly
             180                 185                 190        
 Gly Gln Pro Gly Pro Ser Val Phe Lys Met Glu Asp Lys Gly Ala Ser
         195                 200                 205            
 Pro His Ser Ser Pro Ser Arg Gln Gly Gln Leu Gly Ser Ser Asp Cys
     210                 215                 220                
 Leu Lys Gly Tyr Val Ser Glu Tyr Ser Cys Arg Glu Leu His Phe Thr
 225                 230                 235                 240
 Arg Tyr Val Thr Asp Gly Pro Cys Arg Ser Ala Lys Pro Val Thr Glu
                 245                 250                 255    
 Leu Val Cys Ser Gly Gln Cys Gly Pro Ala Arg Leu Leu Pro Asn Ala
             260                 265                 270        
 Ile Gly Arg Gly Lys Trp Trp Arg Pro Ser Gly Pro Asp Phe Arg Cys
         275                 280                 285            
 Ile Pro Asp Arg Tyr Arg Ala Gln Arg Val Gln Leu Leu Cys Pro Gly
     290                 295                 300                
 Gly Glu Ala Pro Arg Ala Arg Lys Val Arg Leu Val Ala Ser Cys Lys
 305                 310                 315                 320
 Cys Lys Arg Leu Thr Arg Phe His Asn Gln Ser Glu Leu Lys Asp Phe
                 325                 330                 335    
 Gly Thr Glu Ala Ala Arg Pro Gln Lys Gly Arg Lys Pro Arg Pro Arg
             340                 345                 350        
 Ala Arg Ser Ala Lys Ala Asn Gln Ala Glu Leu Glu Asn Ala Tyr
         355                 360                 365        



      <210> 1642
      <211> 288
      <212> PRT
      <213> Homo sapiens


      <400> 1642
 Met Leu Trp His Leu Leu Ser Gln Val Tyr Trp Ile Asn Ala Val Ser
   1               5                  10                  15    
 Asn Ala Gln Val Arg Gly Asp Ser Tyr Glu Ser Gly Cys Leu Gly Arg
              20                  25                  30        
 Thr Gly Ala Arg Val Trp Leu Phe Ile Gly Phe Met Leu Met Phe Gly
          35                  40                  45            
 Ser Leu Ile Ala Ser Met Trp Ile Leu Phe Gly Ala Tyr Val Thr Gln
      50                  55                  60                
 Ser Trp Ser Ala Val Val Gln Pro Gln Leu Thr Ala Pro Ser Asn Ala
  65                  70                  75                  80
 Gly Ala Gln Ala Ile Leu Leu Pro Pro Leu Ser Lys Gln Leu Gly Pro
                  85                  90                  95    
 Gln Lys Lys Leu Phe Cys Leu Arg Phe Pro Glu Arg Ser Lys Val Thr
             100                 105                 110        
 Asp Phe Arg Lys Ala Lys Glu Val Ala Ala Gly Ser Leu Ser Arg Gly
         115                 120                 125            
 Ser Gly Gln Tyr Pro Pro Thr Thr Ala Thr Met Ala Gln Lys Ala Arg
     130                 135                 140                
 Pro Trp Glu Thr Gly Asp Glu Thr Gly Asp Arg Ser Phe Val Cys Phe
 145                 150                 155                 160
 Leu Leu Leu Gly His Glu Lys Thr Gln Leu Asp Pro Ala Leu Ser Arg
                 165                 170                 175    
 Asn Arg Ile Gln Ala Lys Gln Thr Arg Ile His Val Gly Thr Phe Val
             180                 185                 190        
 Asp Glu Gly Lys Asn Thr Asp Ser Leu Gly Ala Val Glu His Val Gln
         195                 200                 205            
 Lys Gly Arg Gly Gly Leu Glu Tyr Val Trp Val Thr Trp Arg Phe Leu
     210                 215                 220                
 Trp Leu Thr Ala Ser Asp Phe Ser Ile Asn Phe Val Ala Lys Ala Pro
 225                 230                 235                 240
 Cys Thr Val Leu Cys Met Val Arg Thr Val Trp Phe Val Ser Asp Ser
                 245                 250                 255    
 Gly Ala Phe Pro Asp Ala Gly Leu Ser Val Leu Lys Leu Gly Lys Pro
             260                 265                 270        
 Arg Val Asn Gln Asp Glu Ser Ala Ala Leu Pro Arg Ala Leu Asp Lys
         275                 280                 285            





      <210> 1643
      <211> 279
      <212> PRT
      <213> Homo sapiens


      <400> 1643
 Met Phe Cys Ile Leu Leu Val Val Glu Ala Phe Ser Leu Gln Lys Val
   1               5                  10                  15    
 Val Lys Met Leu Glu Glu Val Val Ala Gly Trp Arg Glu Val Arg Lys
              20                  25                  30        
 Val Asp Val Glu Leu Phe Ala Asn Phe Pro Cys Asn Cys Lys Arg Ile
          35                  40                  45            
 Ser Phe Glu Asp Cys Ser Gln Leu Val Val Val Asn Phe Arg Trp Ser
      50                  55                  60                
 Ala Thr Met Leu Leu Ile Phe Lys Ala Leu Ile Ser Phe Ala Lys Leu
  65                  70                  75                  80
 Phe Glu Pro Pro Leu Tyr Cys Leu Ile Thr Leu Ile Asn Tyr His Leu
                  85                  90                  95    
 Leu Lys Gly Ser Leu Glu His Arg Thr Ser Pro Gly Leu Arg His Gln
             100                 105                 110        
 Pro Val Leu Ser Leu Ser Leu Ala Gly Ser Val Ala Ser Glu Phe Pro
         115                 120                 125            
 Ala Lys Val Leu Lys Met Phe Glu Asn Phe Pro Leu Ile Thr Lys Pro
     130                 135                 140                
 Thr Pro Leu Ala Gly Asp Met Pro Thr Asn Pro Lys Ala Leu Val Thr
 145                 150                 155                 160
 Gln Arg Lys Gln Pro Phe Phe Arg Ala Phe Ile Thr Cys Asn His Ala
                 165                 170                 175    
 Phe Tyr Arg Gln Pro Lys Tyr Pro Arg Lys Ser Thr Pro Arg Arg Asn
             180                 185                 190        
 Lys Leu Gly His Tyr Val Ile Ile Lys Phe Leu Leu Thr Thr Glu Ser
         195                 200                 205            
 Pro Met Lys Lys Thr Glu Asp Asn Ser Thr Pro Val Phe Ile Val Asp
     210                 215                 220                
 Val Lys Ala Asn Lys His Gln Ile Lys Gln Ala Val Lys Lys Leu Cys
 225                 230                 235                 240
 Asp Ile Asp Val Ala Lys Val Asn Thr Leu Val Arg Thr Asp Arg Glu
                 245                 250                 255    
 Lys Lys Ala His Ile Leu Leu Gly Pro Asp Tyr Asp Ala Leu Asp Val
             260                 265                 270        
 Ala Asn Lys Ile Gly Ile Ile
         275                



      <210> 1644
      <211> 683
      <212> PRT
      <213> Homo sapiens


      <400> 1644
 Met Val Trp Trp Gly Leu Trp Ala Val Leu Leu Pro Gly Val Gly Gly
   1               5                  10                  15    
 Thr Gln Arg Arg Gly Gln Thr Phe Thr Asp Pro Pro Tyr Val His Gly
              20                  25                  30        
 Gly Trp Ile Glu Val Ser Thr Ala Lys Lys Glu Asp Ile Asn Leu Ser
          35                  40                  45            
 Val Arg Lys Leu Leu Asn Arg His Asn Ile Val Phe Gly Asp Tyr Thr
      50                  55                  60                
 Trp Thr Glu Phe Asp Glu Pro Phe Leu Thr Arg Asn Val Gln Ser Val
  65                  70                  75                  80
 Ser Ile Ile Asp Thr Glu Leu Lys Val Lys Asp Ser Gln Pro Ile Asp
                  85                  90                  95    
 Leu Ser Ala Cys Thr Val Ala Leu His Ile Phe Gln Leu Asn Glu Asp
             100                 105                 110        
 Gly Pro Ser Ser Glu Asn Leu Glu Glu Glu Thr Glu Asn Ile Ile Ala
         115                 120                 125            
 Ala Asn His Trp Val Leu Pro Ala Val Cys Gly Glu Thr Gly Gly Phe
     130                 135                 140                
 Gly Trp Ala Leu Ala Gly Gln Ala Gln Gly Phe Ile Gln Ser Val Cys
 145                 150                 155                 160
 Gly Glu Thr Gly Gly Phe Gly Trp Ala Leu Ala Gly Gln Ala Gln Gly
                 165                 170                 175    
 Phe Met Gln Ser Val Cys Gly Glu Thr Gly Gly Phe Gly Trp Ala Leu
             180                 185                 190        
 Ala Gly Gln Ala Gln Gly Phe Ile Gln Ser Val Cys Gly Glu Thr Gly
         195                 200                 205            
 Gly Phe Gly Trp Ala Leu Ala Gly Gln Ala Gln Gly Phe Ile Gln Ser
     210                 215                 220                
 Val Cys Gly Glu Thr Gly Gly Phe Gly Trp Ala Leu Ala Gly Gln Ala
 225                 230                 235                 240
 Gln Gly Phe Ile Gln Ser Val Cys Gly Glu Thr Gly Gly Phe Gly Trp
                 245                 250                 255    
 Ala Leu Ala Gly Gln Ala Gln Gly Phe Ile Gln Ser Val Cys Gly Glu
             260                 265                 270        
 Thr Gly Gly Phe Gly Trp Ala Leu Ala Gly Gln Ala Gln Gly Phe Ile
         275                 280                 285            
 Gln Ser Val Cys Gly Glu Thr Gly Gly Phe Gly Trp Ala Leu Ala Gly
     290                 295                 300                
 Gln Ala His Gly Phe Ile Gln Ser Val Cys Gly Glu Thr Gly Gly Phe
 305                 310                 315                 320
 Gly Trp Ala Leu Ala Gly Gln Ala Gln Gly Phe Ile Gln Ser Ala Lys
                 325                 330                 335    
 Pro Arg Ala Ser Phe Ser Gln Cys Val Gly Lys Gln Val Asp Leu Asp
             340                 345                 350        
 Gly Leu Trp Gln Ala Asn Pro Arg Ala Ser Phe Ile Gln Cys Val Gly
         355                 360                 365            
 Lys Gln Val Asp Leu Asp Gly Leu Trp Gln Ala Lys Pro Gln Gly Leu
     370                 375                 380                
 Ile Gln Leu Val Cys Gly Glu Thr Gly Gly Phe Gly Trp Ala Leu Ala
 385                 390                 395                 400
 Gly Gln Ala Gln Gly Phe Ile Gln Leu Val Cys Gly Glu Thr Gly Gly
                 405                 410                 415    
 Leu Asp Gly Leu Trp Gln Ala Lys Pro Arg Ala Ser Cys Ser Gln Cys
             420                 425                 430        
 Val Gly Lys Gln Val Asp Leu Asp Gly Leu Trp Gln Ala Lys Pro Arg
         435                 440                 445            
 Ala Ser Cys Ser Gln Cys Val Gly Lys Gln Val Asp Leu Asp Gly Leu
     450                 455                 460                
 Trp Gln Ala Lys Pro Arg Ala Ser Phe Ser Gln Cys Val Gly Lys Gln
 465                 470                 475                 480
 Val Asp Leu Asp Gly Leu Trp Gln Ala Lys Pro Arg Ala Ser Cys Ser
                 485                 490                 495    
 Gln Cys Val Gly Lys Gln Val Asp Leu Asp Gly Leu Trp Gln Ala Lys
             500                 505                 510        
 Pro Arg Ala Ser Cys Ser Gln Cys Val Gly Lys Gln Val Asp Leu Asp
         515                 520                 525            
 Gly Leu Trp Gln Ala Lys Pro Arg Ala Ser Phe Ser Gln Cys Val Gly
     530                 535                 540                
 Lys Gln Val Asp Leu Asp Gly Leu Trp Gln Ala Lys Pro Arg Ala Ser
 545                 550                 555                 560
 Phe Ser Gln Cys Val Gly Lys Gln Val Asp Leu Asp Gly Leu Trp Gln
                 565                 570                 575    
 Ala Lys Pro Arg Ala Ser Cys Ser Gln Cys Val Gly Lys Gln Val Asp
             580                 585                 590        
 Leu Asp Gly Leu Trp Gln Ala Lys Pro Arg Ala Phe Met Gln Ser Val
         595                 600                 605            
 Cys Gly Glu Thr Gly Gly Phe Gly Trp Ala Leu Ala Gly Gln Ala Gln
     610                 615                 620                
 Gly Phe Ile Gln Ser Val Cys Gly Glu Thr Gly Gly Phe Gly Trp Ala
 625                 630                 635                 640
 Leu Ala Gly Gln Ala Gln Gly Phe Ile Gln Cys Val Gly Lys Gln Val
                 645                 650                 655    
 Asp Leu Asp Gly Leu Trp Gln Ala Lys Pro Arg Ala Ser Phe Ser Gln
             660                 665                 670        
 Cys Val Gly Lys Gln Val Asp Leu Asp Gly Leu
         675                 680            



      <210> 1645
      <211> 767
      <212> PRT
      <213> Homo sapiens


      <400> 1645
 Met Glu Asn Trp Thr Gly Arg Pro Trp Leu Tyr Leu Leu Leu Leu Leu
   1               5                  10                  15    
 Ser Leu Pro Gln Leu Cys Leu Asp Gln Glu His Pro Gly Ala Trp Leu
              20                  25                  30        
 Pro Leu Leu Ser Asn Gly Pro His Ala Ser Ser Leu Trp Ser Leu Phe
          35                  40                  45            
 Ala Pro Ser Ser Pro Ile Pro Arg Cys Ser Gly Glu Ser Glu Gln Leu
      50                  55                  60                
 Arg Ala Cys Ser Gln Ala Pro Cys Pro Pro Glu Gln Pro Asp Pro Arg
  65                  70                  75                  80
 Ala Leu Gln Cys Ala Ala Phe Asn Ser Gln Glu Phe Met Gly Gln Leu
                  85                  90                  95    
 Tyr Gln Trp Glu Pro Phe Thr Glu Val Gln Gly Ser Gln Arg Cys Glu
             100                 105                 110        
 Leu Asn Cys Arg Pro Arg Gly Phe Arg Phe Tyr Val Arg His Thr Glu
         115                 120                 125            
 Lys Val Gln Asp Gly Thr Leu Cys Gln Pro Gly Ala Pro Asp Ile Cys
     130                 135                 140                
 Val Ala Gly Arg Cys Leu Ser Pro Gly Cys Asp Gly Ile Leu Gly Ser
 145                 150                 155                 160
 Gly Arg Arg Pro Asp Gly Cys Gly Val Cys Gly Gly Asp Asp Ser Thr
                 165                 170                 175    
 Cys Arg Leu Val Ser Gly Asn Leu Thr Asp Arg Gly Gly Pro Leu Gly
             180                 185                 190        
 Tyr Gln Lys Ile Leu Trp Ile Pro Ala Gly Ala Leu Arg Leu Gln Ile
         195                 200                 205            
 Ala Gln Leu Arg Pro Ser Ser Asn Tyr Leu Ala Leu Arg Gly Pro Gly
     210                 215                 220                
 Gly Arg Ser Ile Ile Asn Gly Asn Trp Ala Val Asp Pro Pro Gly Ser
 225                 230                 235                 240
 Tyr Arg Ala Gly Gly Thr Val Phe Arg Tyr Asn Arg Pro Pro Arg Glu
                 245                 250                 255    
 Glu Gly Lys Gly Glu Ser Leu Ser Ala Glu Gly Pro Thr Thr Gln Pro
             260                 265                 270        
 Val Asp Val Tyr Met Ile Phe Gln Glu Glu Asn Pro Gly Val Phe Tyr
         275                 280                 285            
 Gln Tyr Val Ile Ser Ser Pro Pro Pro Ile Leu Glu Asn Pro Thr Pro
     290                 295                 300                
 Glu Pro Pro Val Pro Gln Leu Gln Pro Glu Ile Leu Arg Val Glu Pro
 305                 310                 315                 320
 Pro Leu Ala Pro Ala Pro Arg Pro Ala Arg Thr Pro Gly Thr Leu Gln
                 325                 330                 335    
 Arg Gln Val Arg Ile Pro Gln Met Pro Ala Pro Pro His Pro Arg Thr
             340                 345                 350        
 Pro Leu Gly Ser Pro Ala Ala Tyr Trp Lys Arg Val Gly His Ser Ala
         355                 360                 365            
 Cys Ser Ala Ser Cys Gly Lys Gly Val Trp Arg Pro Ile Phe Leu Cys
     370                 375                 380                
 Ile Ser Arg Glu Ser Gly Glu Glu Leu Asp Glu Arg Ser Cys Ala Ala
 385                 390                 395                 400
 Gly Ala Arg Pro Pro Ala Ser Pro Glu Pro Cys His Gly Thr Pro Cys
                 405                 410                 415    
 Pro Pro Tyr Trp Glu Ala Gly Glu Trp Thr Ser Cys Ser Arg Ser Cys
             420                 425                 430        
 Gly Pro Gly Thr Gln His Arg Gln Leu Gln Cys Arg Gln Glu Phe Gly
         435                 440                 445            
 Gly Gly Gly Ser Ser Val Pro Pro Glu Arg Cys Gly His Leu Pro Arg
     450                 455                 460                
 Pro Asn Ile Thr Gln Ser Cys Gln Leu Arg Leu Cys Gly His Trp Glu
 465                 470                 475                 480
 Val Gly Ser Pro Trp Ser Gln Cys Ser Val Arg Cys Gly Arg Gly Gln
                 485                 490                 495    
 Arg Ser Arg Gln Val Arg Cys Val Gly Asn Asn Gly Asp Glu Val Ser
             500                 505                 510        
 Glu Gln Glu Cys Ala Ser Gly Pro Pro Gln Pro Pro Ser Arg Glu Ala
         515                 520                 525            
 Cys Asp Met Gly Pro Cys Thr Thr Ala Trp Phe His Ser Asp Trp Ser
     530                 535                 540                
 Ser Lys Cys Ser Ala Glu Cys Gly Thr Gly Ile Gln Arg Arg Ser Val
 545                 550                 555                 560
 Val Cys Leu Gly Ser Gly Ala Ala Leu Gly Pro Gly Gln Gly Glu Ala
                 565                 570                 575    
 Gly Ala Gly Thr Gly Gln Ser Cys Pro Thr Gly Ser Arg Pro Pro Asp
             580                 585                 590        
 Met Arg Ala Cys Ser Leu Gly Pro Cys Glu Arg Thr Trp Arg Trp Tyr
         595                 600                 605            
 Thr Gly Pro Trp Gly Glu Cys Ser Ser Glu Cys Gly Ser Gly Thr Gln
     610                 615                 620                
 Arg Arg Asp Ile Ile Cys Val Ser Lys Leu Gly Thr Glu Phe Asn Val
 625                 630                 635                 640
 Thr Ser Pro Ser Asn Cys Ser His Leu Pro Arg Pro Pro Ala Leu Gln
                 645                 650                 655    
 Pro Cys Gln Gly Gln Ala Cys Gln Asp Arg Trp Phe Ser Thr Pro Trp
             660                 665                 670        
 Ser Pro Cys Ser Arg Ser Cys Gln Gly Gly Thr Gln Thr Arg Glu Val
         675                 680                 685            
 Gln Cys Leu Ser Thr Asn Gln Thr Leu Ser Thr Arg Cys Pro Pro Gln
     690                 695                 700                
 Leu Arg Pro Ser Arg Lys Arg Pro Cys Asn Ser Gln Pro Cys Ser Gln
 705                 710                 715                 720
 Arg Pro Asp Asp Gln Cys Lys Asp Ser Ser Pro His Cys Pro Leu Val
                 725                 730                 735    
 Val Gln Ala Arg Leu Cys Val Tyr Pro Tyr Tyr Thr Ala Thr Cys Cys
             740                 745                 750        
 Arg Ser Cys Ala His Val Leu Glu Arg Ser Pro Gln Asp Pro Ser
         755                 760                 765        



      <210> 1646
      <211> 154
      <212> PRT
      <213> Homo sapiens


      <400> 1646
 Met Pro Arg Ser Leu Val Glu Met Leu Leu Leu Cys Leu Phe Ser Leu
   1               5                  10                  15    
 Ser Met Cys Glu Ser Thr Val Gln Gly Ile Leu Pro Ser Arg Ala Ile
              20                  25                  30        
 Pro Glu Leu Asp Ala Tyr Glu Ala Glu Gly Leu Ala Leu Asp Asp Glu
          35                  40                  45            
 Asp Val Glu Glu Leu Thr Ala Ser Gln Arg Glu Ala Ala Lys Arg Ala
      50                  55                  60                
 Met Arg Gln Arg Asp Arg Glu Ala Gly Arg Gly Leu Gly Arg Met Arg
  65                  70                  75                  80
 Arg Gly Leu Leu Tyr Gly Arg Ser Ser Cys Leu Pro Ala Arg Gly Thr
                  85                  90                  95    
 Gly Lys Leu Gly Arg Ser Phe Leu Pro Glu Ala Pro Ala Glu Leu Leu
             100                 105                 110        
 Gln Ile Phe Asp Glu Ala Ala Leu Glu Val Val Leu Ala Met Tyr Pro
         115                 120                 125            
 Lys Tyr Asp Arg Ile Thr Asn His Ile His Val Arg Ile Ser His Leu
     130                 135                 140                
 Pro Leu Val Glu Glu Leu Arg Ser Leu Arg
 145                 150                



      <210> 1647
      <211> 196
      <212> PRT
      <213> Homo sapiens


      <400> 1647
 Met Ala Gln Arg Pro Asp Trp Ser Thr Ser Ala Leu Leu Gly Ser Trp
   1               5                  10                  15    
 Ala Cys Leu Arg Gly Phe Leu Phe Gly Asp Ala Leu Thr His Gly Thr
              20                  25                  30        
 Cys Leu Phe Pro Leu Val Gln Ser Val Tyr Gln Pro Gly Gly Val Ser
          35                  40                  45            
 Cys Ile Leu Val Trp Val Lys Glu Gln Gly Tyr Asp Val Ile Ala Tyr
      50                  55                  60                
 Leu Ala Asn Thr Gly Gln Lys Glu Asp Phe Glu Glu Ala Arg Lys Lys
  65                  70                  75                  80
 Ala Leu Lys Leu Gly Ala Lys Lys Val Phe Ile Glu Asp Val Ile Arg
                  85                  90                  95    
 Glu Phe Val Glu Glu Phe Ile Trp Pro Ala Ile Gln Ser Ser Thr Leu
             100                 105                 110        
 Tyr Glu Asp Arg Tyr Leu Leu Gly Thr Phe Leu Ala Arg Pro Trp Tyr
         115                 120                 125            
 Ser Leu Val Pro Gln Ile Lys Gly Thr Ala Pro Trp Arg Met Pro Glu
     130                 135                 140                
 Phe Tyr Asn Arg Phe Lys Gly Arg Asn Asp Leu Met Glu Tyr Ala Lys
 145                 150                 155                 160
 Gln His Gly Ile Pro Ile Pro Val Thr Pro Lys Asn Pro Trp Asn Met
                 165                 170                 175    
 Asp Glu Asn Leu Met His Ile Ser Tyr Glu Ala Gly Ile Pro Leu Pro
             180                 185                 190        
 Thr Leu Ser Leu
         195    



      <210> 1648
      <211> 168
      <212> PRT
      <213> Homo sapiens


      <400> 1648
 Met Leu Ala Leu Ala Thr Trp Ala Leu Ala Ile Met Ala Gly His Gly
   1               5                  10                  15    
 Gly Trp Leu Gly Ile Gly Asp Thr Val Glu Phe Met Thr Val Thr Tyr
              20                  25                  30        
 Ile Thr Val Gln Asp Met Pro Ala Arg Gly Ala Gln Asp Met Pro Ala
          35                  40                  45            
 Arg Gly Ala Gln Asp Met Pro Ala Arg Gly Ala Gln Asp Met Pro Ala
      50                  55                  60                
 Arg Gly Ala Gln Asp Met Pro Ala Arg Gly Ala Gln Asp Met Pro Ala
  65                  70                  75                  80
 Arg Gly Ala Gln Asp Met Pro Ala Arg Gly Ala Gln Asp Met Pro Ala
                  85                  90                  95    
 Arg Gly Ala Gln Asp Met Pro Ala Arg Gly Ala Gln Asp Met Pro Ala
             100                 105                 110        
 Arg Gly Ala Gln Asp Met Pro Ala Arg Gly Ala Gln Asp Met Pro Ala
         115                 120                 125            
 Arg Gly Ala Gln Asp Met Pro Ala Arg Gly Ala Gln Asp Met Pro Ala
     130                 135                 140                
 Arg Gly Ala Gln Asp Met Pro Ala Arg Gly Ala Gln Asp Met Pro Ala
 145                 150                 155                 160
 Arg Gly Ala Val Ser Leu Phe Cys
                 165            



      <210> 1649
      <211> 514
      <212> PRT
      <213> Homo sapiens


      <400> 1649
 Met Leu Ile Thr Thr Leu Tyr Val Asn Ala Gln Ala Gly Leu Ala Thr
   1               5                  10                  15    
 Val Lys Glu Arg Lys Val Thr Trp Leu Val Val Arg Asp Ser Gln Asn
              20                  25                  30        
 Ser Asn Pro Gly Leu Gly His Ser Val Ala Phe Leu Ser Leu Thr Glu
          35                  40                  45            
 Asp Pro Glu Phe Ile Trp Glu Asn Lys Ala Pro Lys Ile Glu Phe Glu
      50                  55                  60                
 Gln Asn Lys His Gly Leu Asn Gln Val His Ala Pro Ala Gly Asp Ala
  65                  70                  75                  80
 Leu Thr Glu Val Arg Thr Ala Val Pro Gly Gln Leu Gln Thr Pro Thr
                  85                  90                  95    
 Pro Ser Pro Ala Ala Val Ser Pro Thr Asp Ala Glu Ser Lys Ser Arg
             100                 105                 110        
 His Ser Leu Ala Gly Tyr Leu Pro Ser Thr Pro Gln Ser Leu Phe Phe
         115                 120                 125            
 Val Thr Phe Met Thr Ala Ile Ile Thr Thr Lys Ser Lys Thr Gly His
     130                 135                 140                
 Leu Pro Thr Leu Thr Glu Leu Val Cys Ala Asp Pro Phe Leu Ser Lys
 145                 150                 155                 160
 Ser Ile Gln Gly Val Ser Asp Asn Pro Asp Glu Pro Gly Glu Thr Ala
                 165                 170                 175    
 Glu Val Leu Pro Trp Ala Gln Leu Gly Ala Asp Ala Gly Asn Gly Trp
             180                 185                 190        
 Thr Leu Gly Tyr Pro Leu Ala Ser Leu Tyr Pro Ser Thr Thr Lys Lys
         195                 200                 205            
 His Thr Leu Ser His Phe Leu Asn Thr Tyr Cys Val Pro Gly Trp Arg
     210                 215                 220                
 Phe Phe Gly Gly Ile Gly Leu Cys Leu Val Leu Lys Glu Leu Val Glu
 225                 230                 235                 240
 Leu Leu Ala Pro Tyr Pro Glu Leu Ala Ser Ile Leu Asp Ala Ser Cys
                 245                 250                 255    
 Pro Leu Cys Ile Val Thr Val Ser Trp Gly Cys Thr Gly Ser Met Val
             260                 265                 270        
 Ala Ala Lys Val Leu Pro Gln Gly Gly Phe Thr Phe Met Asn Ser Phe
         275                 280                 285            
 Glu Ile Tyr Tyr Ser Leu Val Lys Glu Lys Ala Gln Gly Ser Ser Ser
     290                 295                 300                
 Leu Phe Tyr Arg Tyr Tyr His Pro Ser Ile Gly Lys Asn Ala Lys Arg
 305                 310                 315                 320
 Met Ser Ser Ser Gly His Asp Val Gly Arg Gly Leu Leu His Pro Leu
                 325                 330                 335    
 Leu Gly Thr Glu Asn Cys Arg Pro Asn Phe Leu Ile Cys Lys Val Glu
             340                 345                 350        
 Glu Gly Lys Asp His Tyr Met Ile Ser Val Met Gln Asn Gly Asp Thr
         355                 360                 365            
 Thr Gln Phe Phe Ile Gln Gln Val Phe Ile Glu Tyr Ile Tyr Ser Val
     370                 375                 380                
 Pro Lys Ile Leu Pro Gly Glu Asp Asp Val Ala Asp Ser Pro Arg Phe
 385                 390                 395                 400
 Pro Glu Arg His Ser Thr Cys Arg Ser Pro Gln Pro Ser Arg His Val
                 405                 410                 415    
 Val Ser Ser Leu Leu Ser Leu His Ser Leu Leu Thr Asn Ala Pro Ala
             420                 425                 430        
 Gln Ser Pro Cys Asp His Ser Ser Ser Pro Ala Thr Glu Gln Ser Trp
         435                 440                 445            
 Met Glu Asn Asp Phe Asp Glu Leu Thr Glu Val Gly Phe Arg Arg Ser
     450                 455                 460                
 Val Ile Thr Asn Phe Phe Lys Leu Lys Glu Tyr Val Leu Thr His His
 465                 470                 475                 480
 Lys Glu Ala Lys Asn Leu Glu Lys Met Leu Asp Glu Trp Leu Thr Arg
                 485                 490                 495    
 Ile Asn Ser Val Glu Lys Thr Leu Asn Asp Leu Met Glu Leu Lys Asn
             500                 505                 510        
 Met Ala
        



      <210> 1650
      <211> 248
      <212> PRT
      <213> Homo sapiens


      <400> 1650
 Met Pro Val Gly Gly Leu Leu Pro Leu Phe Ser Ser Pro Ala Gly Gly
   1               5                  10                  15    
 Val Leu Gly Gly Gly Leu Gly Gly Gly Gly Gly Arg Lys Gly Ser Gly
              20                  25                  30        
 Pro Ala Ala Leu Arg Leu Thr Glu Lys Phe Val Leu Leu Leu Val Phe
          35                  40                  45            
 Ser Ala Phe Ile Thr Leu Cys Phe Gly Ala Ile Phe Phe Leu Pro Asp
      50                  55                  60                
 Ser Ser Lys Leu Leu Ser Gly Val Leu Phe His Ser Ser Pro Ala Leu
  65                  70                  75                  80
 Gln Pro Ala Ala Asp His Lys Pro Gly Pro Gly Ala Arg Ala Glu Asp
                  85                  90                  95    
 Ala Ala Glu Gly Arg Ala Arg Arg Arg Glu Glu Gly Ala Pro Gly Asp
             100                 105                 110        
 Pro Glu Ala Ala Leu Glu Asp Asn Leu Ala Arg Ile Arg Glu Asn His
         115                 120                 125            
 Glu Arg Ala Leu Arg Glu Ala Lys Glu Thr Leu Gln Lys Leu Pro Glu
     130                 135                 140                
 Glu Ile Gln Arg Asp Ile Leu Leu Glu Lys Lys Lys Val Ala Gln Asp
 145                 150                 155                 160
 Gln Leu Arg Asp Lys Ala Pro Phe Arg Gly Leu Pro Pro Val Asp Phe
                 165                 170                 175    
 Val Pro Pro Ile Gly Val Glu Ser Arg Glu Pro Ala Asp Ala Ala Ile
             180                 185                 190        
 Arg Glu Lys Arg Ala Lys Ile Lys Glu Val Ile Arg Lys Pro His Ser
         195                 200                 205            
 Leu Ala Ala Thr Arg Leu Ile Ala Pro Pro Val Thr Ala Thr Ala Leu
     210                 215                 220                
 Ile Ser Pro Leu Val Arg Ile Gly Asp Val Ala Leu Asn Pro Lys Trp
 225                 230                 235                 240
 Gln Ala Asn Cys Gln Lys Pro His
                 245            



      <210> 1651
      <211> 360
      <212> PRT
      <213> Homo sapiens


      <400> 1651
 Met Ala Phe Leu Gly Lys Ala Trp Gln Leu Trp Lys Ala Leu Val Glu
   1               5                  10                  15    
 Leu Ala Leu Leu Pro Met Arg Gly Asn Ser Gln Leu Ser His Val Asp
              20                  25                  30        
 Cys Ser Asp Glu Gln Arg Ser Gly His Arg Lys Ser Trp Ala Gln Asp
          35                  40                  45            
 Trp Leu Ser Val Asp Gly Gly Gln Leu Gly Arg Lys Arg Ser Gly Asp
      50                  55                  60                
 Thr Ala Gln Arg Lys Pro Ala Gln Ala Pro Tyr His Ile Ser Ser Ser
  65                  70                  75                  80
 Gln Gly Gly Cys Gln Thr Tyr Met Asp Ile Val Ile Val Leu Asp Gly
                  85                  90                  95    
 Ser Asn Ser Ile Tyr Pro Trp Val Glu Val Gln His Phe Leu Ile Asn
             100                 105                 110        
 Ile Leu Lys Lys Phe Tyr Ile Gly Pro Gly Gln Ile Gln Val Gly Val
         115                 120                 125            
 Val Gln Tyr Gly Glu Asp Val Val His Glu Phe His Leu Asn Asp Tyr
     130                 135                 140                
 Arg Ser Val Lys Asp Val Val Glu Ala Ala Ser His Ile Glu Gln Arg
 145                 150                 155                 160
 Gly Gly Thr Glu Thr Arg Thr Ala Phe Gly Ile Glu Phe Ala Arg Thr
                 165                 170                 175    
 Ser Trp Ser Lys Gly Gly Pro Ala Thr Gly Thr Pro Lys Ala Ser Gly
             180                 185                 190        
 Asp Leu Gly Ala Ser Phe Ser Cys Phe Val Ala Gln Trp Pro Val Thr
         195                 200                 205            
 Arg Ala Ser Leu Pro Ile Asp Gly Arg Gly Ala Ser Pro Ala Val Ser
     210                 215                 220                
 Trp Ala Gly Leu Pro Asp Ser Ser Glu Ala Phe Gln Lys Gly Gly Arg
 225                 230                 235                 240
 Lys Gly Ala Lys Lys Val Met Ile Val Ile Thr Asp Gly Glu Ser His
                 245                 250                 255    
 Asp Ser Pro Asp Leu Glu Lys Val Ile Gln Gln Ser Glu Arg Asp Asn
             260                 265                 270        
 Val Thr Arg Tyr Ala Val Ala Val Leu Gly Tyr Tyr Asn Arg Arg Gly
         275                 280                 285            
 Ile Asn Pro Glu Thr Phe Leu Asn Glu Ile Lys Tyr Ile Ala Ser Asp
     290                 295                 300                
 Pro Asp Asp Lys His Phe Phe Asn Val Thr Asp Glu Ala Ala Leu Lys
 305                 310                 315                 320
 Asp Ile Val Asp Ala Leu Gly Asp Arg Ile Phe Ser Leu Glu Gly Glu
                 325                 330                 335    
 Val Thr Tyr Pro Ala Arg Asp Asp Leu Thr Gly Pro Val Leu Ser Ser
             340                 345                 350        
 Val Met Lys Gln Val Lys Phe Ser
         355                 360



      <210> 1652
      <211> 318
      <212> PRT
      <213> Homo sapiens


      <400> 1652
 Met Lys His Leu Trp Phe Phe Leu Leu Leu Val Ala Ala Pro Arg Leu
   1               5                  10                  15    
 Val Leu Ser Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys
              20                  25                  30        
 Pro Ser Asp Thr Leu Ser Leu Thr Cys Ala Val Ser Gly Tyr Ser Ile
          35                  40                  45            
 Ser Ser Ser Asn Trp Trp Gly Trp Ile Arg Gln Pro Pro Gly Lys Gly
      50                  55                  60                
 Leu Glu Trp Ile Gly Tyr Ile Tyr Tyr Ser Gly Ser Thr Tyr Tyr Asn
  65                  70                  75                  80
 Pro Ser Leu Lys Ser Arg Val Thr Met Ser Val Asp Thr Ser Lys Asn
                  85                  90                  95    
 Gln Phe Ser Leu Lys Leu Ser Ser Val Thr Ala Val Asp Thr Ala Val
             100                 105                 110        
 Tyr Tyr Cys Ala Arg Asn Thr Val Arg Gly Ala Trp Ser Cys Phe Asn
         115                 120                 125            
 Arg Ser Arg Met Gly Met Cys Leu Leu Ser Gly Asp Phe Leu Ser Thr
     130                 135                 140                
 Ala Leu Met Phe Leu Arg Phe Glu Val Tyr Lys Gly Val Ser Val Thr
 145                 150                 155                 160
 His Arg Val Asp Leu His Asn Ile Ile Gln Gln Pro Gln Leu Ser Ser
                 165                 170                 175    
 Glu Glu Ala Pro Arg Pro Gln His Leu Asn Met Tyr Trp Thr Trp Arg
             180                 185                 190        
 Ile Leu Phe Leu Val Ala Ala Ala Thr Gly Val His Ser Gln Val Gln
         195                 200                 205            
 Leu Val Gln Ser Gly Pro Glu Val Lys Lys Pro Gly Ala Ser Leu Lys
     210                 215                 220                
 Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Tyr Ala Ile Ser
 225                 230                 235                 240
 Trp Ala His Gly Gln Gly Leu Glu Glu Met Gly Trp Ile Asn Thr Asn
                 245                 250                 255    
 Thr Gly Asn Leu Thr Tyr Ala Gln Gly Phe Thr Gly Arg Phe Val Phe
             260                 265                 270        
 Ser Met Asp Thr Ser Val Ser Met Ala Tyr Leu His Ile Ser Ser Leu
         275                 280                 285            
 Lys Ala Glu Asp Thr Cys Lys Arg His Ser Val Glu Thr His Ile Leu
     290                 295                 300                
 Arg Glu Pro Glu Ile Leu Arg Glu Glu Ala Ala Val Leu Ser
 305                 310                 315            



      <210> 1653
      <211> 136
      <212> PRT
      <213> Homo sapiens


      <400> 1653
 Met Thr Trp Asn Thr Leu Ser Leu Ser Pro Leu Leu Ser Leu Ser Leu
   1               5                  10                  15    
 Ser Leu Leu Pro Leu Phe Leu Phe Leu Phe Phe Cys Phe Ser Phe Cys
              20                  25                  30        
 Pro Ser Ser Leu His Gln Ala Gly Gln Arg Pro Val Glu Glu Phe Glu
          35                  40                  45            
 Leu Cys Leu Pro Asp Gly Asp Val Ser Ile His Gly Ala Val Gly Ala
      50                  55                  60                
 Ser Glu Leu Ala Asn Thr Ala Lys Ala Gly Glu Glu Glu Pro Glu Glu
  65                  70                  75                  80
 Pro Arg Pro Gly Gly Gly Pro Gly Leu Ala Asn Gln Gln Gly Gln Lys
                  85                  90                  95    
 Gly Trp Tyr Arg Glu Asp Trp Leu Cys Cys Val Cys Arg Leu Phe Gln
             100                 105                 110        
 Gln Leu Pro Cys Leu Asn Arg Ala Gly Glu Gln Arg Arg Ala Ala Arg
         115                 120                 125            
 Gly Val Leu Ala Val Phe Pro Arg
     130                 135    



      <210> 1654
      <211> 153
      <212> PRT
      <213> Homo sapiens


      <400> 1654
 Met Thr Leu Leu Ser Leu Leu Gly Arg Ile Met Arg Tyr Phe Leu Leu
   1               5                  10                  15    
 Arg Pro Glu Thr Leu Phe Leu Leu Cys Ile Ser Leu Ala Leu Trp Ser
              20                  25                  30        
 Tyr Phe Phe His Thr Asp Glu Val Lys Thr Ile Val Lys Ser Ser Arg
          35                  40                  45            
 Asp Ala Val Lys Met Val Lys Gly Lys Val Ala Glu Ile Met Gln Asn
      50                  55                  60                
 Asp Arg Leu Gly Gly Leu Asp Val Leu Glu Ala Glu Phe Ser Lys Thr
  65                  70                  75                  80
 Trp Glu Phe Lys Asn His Asn Val Ala Val Tyr Ser Ile Gln Gly Arg
                  85                  90                  95    
 Arg Asp His Met Glu Asp Arg Phe Glu Val Leu Thr Asp Leu Ala Asn
             100                 105                 110        
 Lys Thr His Pro Ser Ile Phe Gly Ile Phe Asp Gly His Gly Gly Glu
         115                 120                 125            
 Ala Asn Arg Leu Tyr Leu Gln Ser Glu Leu Ile Glu Gly Glu Gly Ser
     130                 135                 140                
 Cys Asp Ser Phe Pro Ser Pro Ser Leu
 145                 150            



      <210> 1655
      <211> 150
      <212> PRT
      <213> Homo sapiens


      <400> 1655
 Met Asp Val His Ser Tyr Tyr Phe Asn Ile Val Leu Leu Leu Leu Ala
   1               5                  10                  15    
 Ser Met Ile Arg Asn Glu Gly Thr Trp Gly Asn Cys Thr Asp Leu Trp
              20                  25                  30        
 Val Arg Leu Ser Pro Thr Ala Ile Pro Ala Lys Arg Tyr Pro Pro Asp
          35                  40                  45            
 Thr His Met Gly Ser Arg Val Leu Leu Ser Gln Asp Leu Ser Ala Ser
      50                  55                  60                
 Lys Phe Ser Met Ile Ile Leu Glu Thr Ile His Ser Gly Pro Lys Ala
  65                  70                  75                  80
 Arg His Thr Pro Pro Pro Ala Gln Gln Ile Tyr Pro Asp Arg Lys Arg
                  85                  90                  95    
 Asp Thr Arg Leu Asp Pro Ser Leu Leu Ser Ala Ser Gly Pro Gly Ala
             100                 105                 110        
 Cys Trp Leu Arg Arg Lys Gly Lys Ser Lys Glu Ser Glu Gly Glu Gly
         115                 120                 125            
 Gln Leu Asn Gly Asn Asp Ser Gly Gly Leu Pro Gly Ser Gln His Pro
     130                 135                 140                
 Gln Glu Asp Gly Cys Arg
 145                 150



      <210> 1656
      <211> 234
      <212> PRT
      <213> Homo sapiens


      <400> 1656
 Met Glu Thr Val Val Ile Val Ala Ile Gly Val Leu Ala Thr Ile Phe
   1               5                  10                  15    
 Leu Ala Ser Phe Ala Ala Leu Val Leu Val Cys Arg Gln Arg Tyr Cys
              20                  25                  30        
 Arg Pro Arg Asp Leu Leu Gln Arg Tyr Asp Ser Asn Val Thr Arg Lys
          35                  40                  45            
 Arg Gln Gly Tyr Arg Asp Gly Pro Lys Trp Phe Thr Arg Val Ile Leu
      50                  55                  60                
 Gln Thr Arg Pro Ile Val Asp Leu Ile Gly Ala Met Glu Thr Gln Ser
  65                  70                  75                  80
 Glu Pro Ser Glu Leu Glu Leu Asp Asp Val Val Ile Thr Asn Pro His
                  85                  90                  95    
 Ile Glu Ala Ile Leu Glu Asn Glu Asp Trp Ile Glu Asp Ala Ser His
             100                 105                 110        
 Pro Phe Pro Gly Pro Met Phe Val Gly His Tyr Val Glu Gly Thr Gly
         115                 120                 125            
 Ser Gly Ala Ala Asp Ile Glu Thr Val Glu Lys Thr Val Ile Val Ser
     130                 135                 140                
 Ile Thr Glu Thr Val Arg Asp Pro Cys Val Gln Cys Ser Arg His Met
 145                 150                 155                 160
 Glu Lys Ala Val Ser Arg Phe Ala Trp Val Gly Glu Val Glu Leu Asp
                 165                 170                 175    
 Leu Met Glu Asp Ile Thr Glu Glu Gly Ser His Val Pro Leu His Cys
             180                 185                 190        
 His Leu Glu Gly Asn Pro Leu Leu Phe Leu Cys Gly Ile Lys Gly Ser
         195                 200                 205            
 Arg Lys Ala Pro Leu Cys Val Asp Gly Val Glu Arg Asp Leu Arg Lys
     210                 215                 220                
 Gly Thr Asp Leu Ser Gln Glu Ala Phe Pro
 225                 230                



      <210> 1657
      <211> 176
      <212> PRT
      <213> Homo sapiens


      <400> 1657
 Met Arg Leu Leu Pro Leu Ala Pro Gly Arg Leu Arg Arg Gly Ser Pro
   1               5                  10                  15    
 Arg His Leu Pro Ser Cys Ser Pro Ala Leu Leu Leu Leu Val Leu Gly
              20                  25                  30        
 Gly Cys Leu Gly Val Phe Gly Val Ala Ala Gly Thr Arg Arg Pro Asn
          35                  40                  45            
 Val Val Leu Leu Leu Thr Asp Asp Gln Asp Glu Val Leu Gly Gly Met
      50                  55                  60                
 Val Thr Leu Leu Phe Leu Pro Arg Pro Ser Ile Ser Trp Ala Asp Tyr
  65                  70                  75                  80
 Pro Val Cys Cys Ser Leu Ser Arg Ser Pro Pro Pro Ser Ser Pro Asn
                  85                  90                  95    
 Trp Leu Ser Tyr Pro Trp Val Gly Leu Val Phe Pro Pro Glu Ala Leu
             100                 105                 110        
 Tyr Ala Gly Val Arg Asp Cys Asn Thr Leu Phe Leu Ser Gly Leu Arg
         115                 120                 125            
 His Met Arg Thr Ala His Arg Ala Ser Ser Leu Asp Arg Thr Ala Val
     130                 135                 140                
 Glu Phe Thr Leu Ile Ser Gln Asp Lys His Val Glu Thr Ser Gly Gly
 145                 150                 155                 160
 Trp Val Glu Pro Met Arg Ile Arg Cys Cys Leu Arg Ala Leu Lys Ala
                 165                 170                 175    





      <210> 1658
      <211> 740
      <212> PRT
      <213> Homo sapiens


      <400> 1658
 Met Ala Phe Pro Pro Val Ala Gln Leu Pro Val Gly Leu Ala Ala Val
   1               5                  10                  15    
 Trp Ala Gly Pro Leu Asp Phe Ser Gly Ser His Ala Gly Lys Ser Pro
              20                  25                  30        
 His Gln Gln Gln Phe Leu Val Phe Gln Gln Gln Leu His Pro Leu Leu
          35                  40                  45            
 Lys Val Trp Gly Ser Thr Arg Gly Gly Gly Ser Leu Ser Ser Phe Ile
      50                  55                  60                
 Val Asp Ser Leu Ser Ala Leu Lys Lys Leu Gly Ala Pro Glu Gln Ala
  65                  70                  75                  80
 Ala Ile Leu Cys Leu Gly Phe Ser Asp Cys Lys Met Arg Ile Ile Thr
                  85                  90                  95    
 Ala Pro Ala Ser Lys Val Ser Arg Gly Ser Asn Glu Leu Met Ile Leu
             100                 105                 110        
 Ala Arg Arg Ser Asp Arg Gly Trp Gly Leu Gly Phe Pro Gly Gly Arg
         115                 120                 125            
 Thr Trp Lys Glu Tyr Ala Pro Asp Lys Ala Arg Asp Gly Asn Gly Thr
     130                 135                 140                
 Arg Leu Ala His Cys Gln Arg Pro Gly Gln Glu Gly Gly Leu Arg Ser
 145                 150                 155                 160
 Pro Thr Ala Gly Ala Val Pro Ala Gly Lys Gly Ala Arg Glu Asn Leu
                 165                 170                 175    
 Asp Pro Leu Ala Arg Thr Arg Gln Ala Cys Lys Leu Thr Glu Phe His
             180                 185                 190        
 Gln Phe Lys His Lys His Ser Ala Lys Thr Asn Gly Glu Leu Ile Gly
         195                 200                 205            
 Thr Glu Val Lys Leu Ile Asn Arg Ile Leu Pro Ser Thr Gly Leu Leu
     210                 215                 220                
 Cys Asn Gly Arg Asp Trp Lys Gln Gln Thr Arg Ser Thr Ala Ser Arg
 225                 230                 235                 240
 Gly Glu Lys Ile Pro Pro Ala Ser Met Arg Arg Asp Leu Arg Glu Lys
                 245                 250                 255    
 Leu Val Trp Val Cys Arg Pro Leu Ala Pro Val Glu Val Pro Ala Asn
             260                 265                 270        
 Ile Ser Ser Asp Phe Gln Pro Cys Ser Pro Thr Ser Pro Ala His Ser
         275                 280                 285            
 Leu Ser Arg Lys Ser Pro Ile Met Tyr Pro Ser Thr Thr Met Ala Asn
     290                 295                 300                
 Ala Pro Gly Leu Val Ser Cys Thr Phe Phe Leu Ala Val Asn Gly Leu
 305                 310                 315                 320
 Tyr Ser Ser Ser Asp Asp Val Ile Glu Leu Thr Pro Ser Asn Phe Asn
                 325                 330                 335    
 Arg Glu Val Ile Gln Ser Asp Ser Leu Trp Leu Val Glu Phe Tyr Ala
             340                 345                 350        
 Pro Trp Cys Gly His Cys Gln Arg Leu Thr Pro Glu Trp Lys Lys Ala
         355                 360                 365            
 Ala Thr Ala Leu Lys Asp Val Val Lys Val Gly Ala Val Asp Ala Asp
     370                 375                 380                
 Lys His His Ser Leu Gly Gly Gln Tyr Gly Val Gln Gly Phe Pro Thr
 385                 390                 395                 400
 Ile Lys Ile Phe Gly Ser Asn Lys Asn Arg Pro Glu Asp Tyr Gln Gly
                 405                 410                 415    
 Gly Arg Thr Gly Glu Ala Ile Val Asp Ala Ala Leu Ser Ala Leu Arg
             420                 425                 430        
 Gln Leu Val Lys Asp Arg Leu Gly Gly Arg Ser Gly Gly Tyr Ser Ser
         435                 440                 445            
 Gly Lys Gln Gly Arg Ser Asp Ser Ser Ser Lys Lys Asp Val Ile Glu
     450                 455                 460                
 Leu Thr Asp Asp Ser Phe Asp Lys Asn Val Leu Asp Ser Glu Asp Val
 465                 470                 475                 480
 Trp Met Val Glu Phe Tyr Ala Pro Trp Cys Gly His Cys Lys Asn Leu
                 485                 490                 495    
 Glu Pro Glu Trp Ala Ala Ala Ala Ser Glu Val Lys Glu Gln Thr Lys
             500                 505                 510        
 Gly Lys Val Lys Leu Ala Ala Val Asp Ala Thr Val Asn Gln Val Leu
         515                 520                 525            
 Ala Ser Arg Tyr Gly Ile Arg Gly Phe Pro Thr Ile Lys Ile Phe Gln
     530                 535                 540                
 Lys Gly Glu Ser Pro Val Asp Tyr Asp Gly Gly Arg Thr Arg Ser Asp
 545                 550                 555                 560
 Ile Val Ser Arg Ala Leu Asp Leu Phe Ser Asp Asn Ala Pro Pro Pro
                 565                 570                 575    
 Glu Leu Leu Glu Ile Ile Asn Glu Asp Ile Ala Lys Arg Thr Cys Glu
             580                 585                 590        
 Glu His Gln Leu Cys Val Val Ala Val Leu Pro His Ile Leu Asp Thr
         595                 600                 605            
 Gly Ala Ala Gly Arg Asn Ser Tyr Leu Glu Val Leu Leu Lys Leu Ala
     610                 615                 620                
 Asp Lys Tyr Lys Lys Lys Met Trp Gly Trp Leu Trp Thr Glu Ala Gly
 625                 630                 635                 640
 Ala Gln Ser Glu Leu Glu Thr Ala Leu Gly Ile Gly Gly Phe Gly Tyr
                 645                 650                 655    
 Pro Ala Met Ala Ala Ile Asn Ala Arg Lys Met Lys Phe Ala Leu Leu
             660                 665                 670        
 Lys Gly Ser Phe Ser Glu Gln Gly Ile Asn Glu Phe Leu Arg Glu Leu
         675                 680                 685            
 Ser Phe Gly Arg Gly Ser Thr Ala Pro Val Gly Gly Gly Ala Phe Pro
     690                 695                 700                
 Thr Ile Val Glu Arg Glu Pro Trp Asp Gly Arg Asp Gly Glu Leu Pro
 705                 710                 715                 720
 Val Glu Asp Asp Ile Asp Leu Ser Asp Val Glu Leu Asp Asp Leu Gly
                 725                 730                 735    
 Lys Asp Glu Leu
             740



      <210> 1659
      <211> 171
      <212> PRT
      <213> Homo sapiens


      <400> 1659
 Met Ala Leu Thr Leu Val Val Val Val Gly Trp Gln Glu Ala Cys Ser
   1               5                  10                  15    
 Asn Phe Gly Asn Thr Leu Lys Val Glu Gln Arg Gly Phe Met Gly Arg
              20                  25                  30        
 Leu Asp Asp Glu Cys Arg Arg Lys Arg Gly Ile Asn Glu Asp Lys Val
          35                  40                  45            
 Trp Thr Ile Val Ser His Asp Leu Gln Met Gln Thr Pro Val Val Gly
      50                  55                  60                
 Tyr Asn Pro Glu Lys Tyr Ser Val Thr Gln Leu Val Tyr Ser Ala Ser
  65                  70                  75                  80
 Met Asp Gln Ile Ser Ala Ile Thr Asp Ser Ala Glu Tyr Cys Glu Gln
                  85                  90                  95    
 Tyr Val Ser Tyr Phe Cys Lys Met Ser Arg Leu Leu Asn Thr Pro Glu
             100                 105                 110        
 Glu Thr Leu Met Ser Lys Pro Asn Thr Ser Asp Thr Ser Ser Val Ser
         115                 120                 125            
 Phe Leu Pro Tyr Lys Phe Ala Phe Asp Arg Val Leu Arg Asp Pro Val
     130                 135                 140                
 Lys Thr Arg Lys Ile Arg Asn His Gln Leu Gly Arg Ala Arg Leu Leu
 145                 150                 155                 160
 Thr Phe Leu Ser Leu His Ile Thr Glu Glu Ser
                 165                 170    



      <210> 1660
      <211> 122
      <212> PRT
      <213> Homo sapiens


      <400> 1660
 Met Gly Ser Cys Leu Phe Ser Ser Leu Gln Pro Phe Pro Ser Trp Ala
   1               5                  10                  15    
 Val Leu Lys Gly Leu Ser Tyr Ala Ser Gln Thr Arg Gly Leu Glu Leu
              20                  25                  30        
 Trp Pro Lys Leu Thr Pro Val Gln Met Tyr Thr Gly Ser Phe Thr Tyr
          35                  40                  45            
 Trp Val Arg Ser Met Leu Ser Arg His Lys Leu Asp Ala Ile Leu Gly
      50                  55                  60                
 Arg Leu Gly Tyr Thr Ala Thr Leu Glu Ser Glu Phe Ser Leu Val Gln
  65                  70                  75                  80
 Ala Ile Ser Lys Glu Asn Val Lys Gln Met Val Phe Lys Ile Phe Leu
                  85                  90                  95    
 Glu His Ser Ser Ser Pro Ala Thr Glu Gln Ser Trp Thr Glu Asn Asp
             100                 105                 110        
 Phe Asp Glu Leu Arg Glu Glu Gly Phe Arg
         115                 120        



      <210> 1661
      <211> 335
      <212> PRT
      <213> Homo sapiens


      <400> 1661
 Met Ala Lys Gly Ile Pro Leu Gly Thr Leu Ser Gly Leu Trp Ala Ser
   1               5                  10                  15    
 Phe Gln Cys Leu Met Ser Gly Thr Tyr Gly Asp Ala Met Glu Pro Ser
              20                  25                  30        
 Pro Glu Ala Trp Val Cys Val Lys Gly Leu Trp Phe Trp Ala Leu Gly
          35                  40                  45            
 Gly Asn Gly Thr Ser Ala Trp Gly Thr Gly Thr Pro Thr Ala Val Leu
      50                  55                  60                
 Val Met Val Cys Phe Ala Ser Gln Ser Asp Asp Asp Gln Val Asn Val
  65                  70                  75                  80
 Met Gly Phe His Phe Leu Gly Gly Ala Arg Ile Thr Val Leu Ala Ser
                  85                  90                  95    
 Lys Thr Ser Arg Ala Ala Ala Arg Glu Leu Glu Glu Leu Met Thr Ser
             100                 105                 110        
 Leu Phe Glu Glu Ala His Lys Met Val Trp Glu Ala Ser Ile Gln Gln
         115                 120                 125            
 Ala Val Ser Glu Lys Gln Leu Asn Ala Glu Ala Trp Gly Lys Ile Asp
     130                 135                 140                
 Met Leu Gln Ala Glu Gly Val Val Gly Gly Tyr Gly Pro Leu Pro Gly
 145                 150                 155                 160
 Leu His Ser Ala Glu Ser Leu Ala Thr Gly Val Gly Leu Tyr Gly Gly
                 165                 170                 175    
 His His Thr His Tyr Gln Ala Cys Gly Ser Ala Glu Ala Ala Tyr Ser
             180                 185                 190        
 Glu Glu Arg Tyr Arg Ile Gln Ser Glu Gln Phe Glu Asp Leu Trp Leu
         195                 200                 205            
 Ile Thr Asn Glu Leu Ile Leu Arg Leu Gln Glu Tyr Phe Glu Lys Gln
     210                 215                 220                
 Gly Val Lys Asp Phe Ala Cys Ser Phe Ser Gly Ser Ile Pro Leu Gln
 225                 230                 235                 240
 Glu Tyr Phe Glu Leu Ile Asp His His Phe Glu Leu Arg Ile Asn Gly
                 245                 250                 255    
 Glu Lys Leu Glu Glu Leu Leu Ser Glu Arg Ala Val Gln Phe Arg Ala
             260                 265                 270        
 Ile Gln Arg Arg Leu Leu Ala Arg Phe Lys Asp Lys Thr Pro Ala Pro
         275                 280                 285            
 Leu Gln His Leu Asp Thr Leu Leu Asp Gly Thr Tyr Lys Gln Ser Val
     290                 295                 300                
 Ser Pro His Ala Leu Ala Lys Ser Arg Pro Trp Ser Gln Gly Ser Pro
 305                 310                 315                 320
 Gln Val Leu Val Leu Met Val Lys Cys Val Asn Lys Leu Pro His
                 325                 330                 335



      <210> 1662
      <211> 1787
      <212> PRT
      <213> Homo sapiens


      <400> 1662
 Met Thr Leu His Leu His Pro Asp Leu Trp Val Leu Ala Gln Ala Ala
   1               5                  10                  15    
 Pro Ala Leu Val Asp Val Ala Thr Ala Leu Pro Leu Gln Val Ala Pro
              20                  25                  30        
 Ser Ala Val Pro Met Asp Leu Arg Leu Asp His Gln Phe Ser Leu Pro
          35                  40                  45            
 Val Ala Glu Pro Ala Leu Arg Glu Gln Gln Leu Gln Gln Glu Leu Leu
      50                  55                  60                
 Ala Leu Lys Gln Lys Gln Gln Ile Gln Arg Gln Ile Leu Ile Ala Glu
  65                  70                  75                  80
 Phe Gln Arg Gln His Glu Gln Leu Ser Arg Gln His Glu Ala Gln Leu
                  85                  90                  95    
 His Glu His Ile Lys Lys Val Pro Arg Ala Thr Leu Val Ala Arg Met
             100                 105                 110        
 Pro Ala Tyr Pro Val Pro Ser His Arg Pro Leu Phe Leu His Lys Gly
         115                 120                 125            
 Ser Lys Thr Asn Lys Lys Gln Pro Thr Ser Gly Arg Gln Gln Gln Glu
     130                 135                 140                
 Met Leu Ala Met Lys His Gln Gln Glu Leu Leu Glu His Gln Arg Lys
 145                 150                 155                 160
 Leu Glu Arg His Arg Gln Glu Gln Glu Leu Glu Lys Gln His Arg Glu
                 165                 170                 175    
 Gln Lys Leu Gln Gln Leu Lys Asn Lys Glu Lys Gly Lys Glu Arg Cys
             180                 185                 190        
 Ser Ala Lys Leu Ile Pro Ser Gly Thr Arg Leu Ala Val Phe Leu Leu
         195                 200                 205            
 Leu Lys Leu Pro Ser Ala Val Ala Ser Thr Glu Val Lys Met Lys Leu
     210                 215                 220                
 Gln Glu Phe Val Leu Asn Lys Lys Lys Ala Leu Ala His Arg Asn Leu
 225                 230                 235                 240
 Asn His Cys Ile Ser Ser Asp Pro Arg Tyr Trp Tyr Gly Lys Thr Gln
                 245                 250                 255    
 His Ser Ser Leu Asp Gln Ser Ser Pro Pro Gln Ser Gly Val Ser Thr
             260                 265                 270        
 Ser Tyr Asn His Pro Val Leu Gly Met Tyr Asp Ala Lys Asp Asp Phe
         275                 280                 285            
 Pro Leu Arg Lys Thr Gly Leu Ile Ser Ser Leu Leu Ala Cys Leu His
     290                 295                 300                
 Leu Ser Ala Ile Ser Gln Glu Glu Pro Pro Pro Leu Gly Leu Arg Val
 305                 310                 315                 320
 Arg Asp Leu Tyr Pro Gly Pro Gln Val Gln Leu Phe Leu Pro Glu Ala
                 325                 330                 335    
 Pro Pro Leu Ser Trp Glu Ile Gly Ser Arg Gly Val Ser Thr Ser Glu
             340                 345                 350        
 Val Phe Thr Ser Arg Gln Ile Ser Ala Gln Ala Ser Glu Pro Asn Leu
         355                 360                 365            
 Lys Leu Arg Ser Arg Leu Lys Gln Lys Val Ala Glu Arg Arg Ser Ser
     370                 375                 380                
 Pro Leu Leu Arg Arg Lys Asp Gly Pro Val Val Thr Ala Leu Lys Lys
 385                 390                 395                 400
 Arg Pro Leu Asp Val Thr Asp Ser Ala Cys Ser Ser Ala Pro Gly Ser
                 405                 410                 415    
 Gly Pro Ser Ser Pro Asn Asn Ser Ser Gly Ser Val Ser Ala Glu Asn
             420                 425                 430        
 Gly Ile Ala Pro Ala Val Pro Ser Ile Pro Ala Glu Thr Ser Leu Ala
         435                 440                 445            
 His Arg Leu Val Ala Arg Glu Gly Ser Ala Ala Pro Leu Pro Leu Tyr
     450                 455                 460                
 Thr Ser Pro Ser Leu Pro Asn Ile Thr Leu Gly Leu Pro Ala Thr Gly
 465                 470                 475                 480
 Pro Ser Ala Gly Thr Ala Gly Gln Gln Asp Ala Glu Arg Leu Thr Leu
                 485                 490                 495    
 Pro Ala Leu Gln Gln Arg Leu Ser Leu Phe Pro Gly Thr His Leu Thr
             500                 505                 510        
 Pro Tyr Leu Ser Thr Ser Pro Leu Glu Arg Asp Gly Gly Ala Ala His
         515                 520                 525            
 Ser Pro Leu Leu Gln His Met Val Leu Leu Glu Gln Pro Pro Ala Gln
     530                 535                 540                
 Ala Pro Leu Val Thr Gly Leu Gly Ala Leu Pro Leu His Ala Gln Ser
 545                 550                 555                 560
 Leu Val Gly Ala Asp Arg Val Ser Pro Ser Ile His Lys Leu Arg Gln
                 565                 570                 575    
 His Arg Pro Leu Gly Arg Thr Gln Ser Ala Pro Leu Pro Gln Asn Ala
             580                 585                 590        
 Gln Ala Leu Gln His Leu Val Ile Gln Gln Gln His Gln Gln Phe Leu
         595                 600                 605            
 Glu Lys His Lys Gln Gln Phe Gln Gln Gln Gln Leu Gln Met Asn Lys
     610                 615                 620                
 Ile Ile Pro Lys Pro Ser Glu Pro Ala Arg Gln Pro Glu Ser His Pro
 625                 630                 635                 640
 Glu Glu Thr Glu Glu Glu Leu Arg Glu His Gln Ala Leu Leu Asp Glu
                 645                 650                 655    
 Pro Tyr Leu Asp Arg Leu Pro Gly Gln Lys Glu Ala His Ala Gln Ala
             660                 665                 670        
 Gly Val Gln Val Lys Gln Glu Pro Ile Glu Ser Asp Glu Glu Glu Ala
         675                 680                 685            
 Glu Pro Pro Arg Glu Val Glu Pro Gly Gln Arg Gln Pro Ser Glu Gln
     690                 695                 700                
 Glu Leu Leu Phe Arg Gln Gln Ala Leu Leu Leu Glu Gln Gln Arg Ile
 705                 710                 715                 720
 His Gln Leu Arg Asn Tyr Gln Ala Ser Met Glu Ala Ala Gly Ile Pro
                 725                 730                 735    
 Val Ser Phe Gly Gly His Arg Pro Leu Ser Arg Ala Gln Ser Ser Pro
             740                 745                 750        
 Ala Ser Ala Thr Phe Pro Val Ser Val Gln Glu Pro Pro Thr Lys Pro
         755                 760                 765            
 Arg Phe Thr Thr Ala Phe Leu Ser Val Lys Ala Val Lys Gln Val Ser
     770                 775                 780                
 Ala Ser Asn Arg Asn Thr Ser Gly Glu Gly Arg Ile Leu Gly Gln His
 785                 790                 795                 800
 Thr Glu Ala Ile Glu Gln Val Cys Leu Gly Ser Leu Pro Arg Leu Phe
                 805                 810                 815    
 Thr Val Arg Pro Ala Leu Ile Ser Leu Asp Glu Pro Thr Leu Ala Gln
             820                 825                 830        
 Val Pro Leu Ala Ser Asp Leu Pro Ala Glu Gly Val Cys Ser Pro Ser
         835                 840                 845            
 Leu Ala Phe Pro Leu Leu Ser Pro Gly Arg Pro Gly Leu Val Tyr Asp
     850                 855                 860                
 Thr Leu Met Leu Lys His Gln Cys Thr Cys Gly Ser Ser Ser Ser His
 865                 870                 875                 880
 Pro Glu His Ala Gly Arg Ile Gln Ser Ile Trp Ser Arg Leu Gln Glu
                 885                 890                 895    
 Thr Gly Leu Arg Gly Lys Cys Glu Cys Ile Arg Gly Arg Lys Ala Thr
             900                 905                 910        
 Leu Glu Glu Leu Gln Thr Val His Ser Glu Ala His Thr Leu Leu Tyr
         915                 920                 925            
 Gly Thr Asn Pro Leu Asn Arg Gln Lys Leu Asp Arg Ala Asp Asn Gln
     930                 935                 940                
 Gly Gly Pro Arg Ala Arg Gly Thr Ala Gly Gln Gly Pro Gly Ala Gly
 945                 950                 955                 960
 Ala Thr Gln Gly Lys Glu Ala Gly Gly Arg Gln Cys Glu Ala Leu Thr
                 965                 970                 975    
 Gln Leu Pro Leu Ala Pro Ser Glu Arg Met Pro His Pro Arg Asn Val
             980                 985                 990        
 Asp Lys Phe Ser Gly Lys Gly Glu Ser Thr Glu Arg Ser Glu Lys Thr
         995                1000                1005            
 Lys Ile Lys His Leu Thr Ala Glu Lys Glu Asn Pro Pro Gln Thr Gly
    1010                1015                1020                
 Arg Tyr Gly Asp Val Ile Ser Gln Lys Leu Glu Gln Asn Val Thr Ala
1025                1030                1035                1040
 Leu Gly Asn Trp Glu Ala Arg Ser Pro Pro Cys Ser Ser Gly Ser Leu
                1045                1050                1055    
 Ala Val Val Leu Gly Asp Arg Lys Phe Gln Leu Gly Glu Glu Leu Val
            1060                1065                1070        
 Ser Leu Leu Gly Leu Ala Gln Arg Ser Pro Gly Leu Leu Ser Ser Ala
        1075                1080                1085            
 Ser Leu Ile Gln Lys Ser Glu Ile Gln Asn Ala Pro Glu Cys Ile Ser
    1090                1095                1100                
 Phe Glu Arg His Val Asp Ser Asp Thr Ile Trp Asn Glu Val His Ser
1105                1110                1115                1120
 Ala Gly Ala Ala Arg Leu Ala Val Gly Cys Val Val Glu Leu Val Phe
                1125                1130                1135    
 Lys Val Ala Thr Gly Glu Leu Lys Gly Arg Asp Tyr Val Arg Asp Ser
            1140                1145                1150        
 Gln Ile Arg Val Leu Glu Gln Ser Leu Leu His Val Gln Gly Gly Asp
        1155                1160                1165            
 Trp Lys Arg Leu Tyr Val Arg Asp Ser Gln Ile Arg Val Leu Glu Gln
    1170                1175                1180                
 Ser Leu Leu Arg Val Gln Gly Arg Asp Tyr Val Arg Asp Ser Gln Ile
1185                1190                1195                1200
 Arg Val Leu Glu Gln Ser Leu Leu His Val Gln Gly Gly Asp Trp Lys
                1205                1210                1215    
 Arg Leu Tyr Val Arg Asp Ser Gln Ile Arg Val Leu Glu Gln Ser Leu
            1220                1225                1230        
 Leu Arg Val Gln Gly Gly Asp Ser Ser Val Leu Ser Arg Arg Gly Phe
        1235                1240                1245            
 Cys Tyr Phe Asn Ser Val Ala Val Ala Ala Lys Leu Leu Gln Gln Arg
    1250                1255                1260                
 Leu Ser Val Ser Lys Ile Leu Ile Val Asp Trp Asp Val His His Gly
1265                1270                1275                1280
 Asn Gly Thr Gln Gln Ala Phe Tyr Ser Asp Pro Ser Val Leu Tyr Met
                1285                1290                1295    
 Ser Leu His Arg Tyr Asp Asp Gly Asn Phe Phe Pro Gly Ser Gly Ala
            1300                1305                1310        
 Pro Asp Glu Val Gly Thr Gly Pro Gly Val Gly Phe Asn Val Asn Met
        1315                1320                1325            
 Ala Phe Thr Gly Gly Leu Asp Pro Pro Met Gly Asp Ala Glu Tyr Leu
    1330                1335                1340                
 Ala Ala Phe Arg Thr Val Val Met Pro Ile Ala Ser Glu Phe Ala Pro
1345                1350                1355                1360
 Asp Val Val Leu Val Ser Ser Gly Phe Asp Ala Val Glu Gly His Pro
                1365                1370                1375    
 Thr Pro Leu Gly Gly Tyr Asn Leu Ser Ala Arg Cys Phe Gly Tyr Leu
            1380                1385                1390        
 Thr Lys Gln Leu Met Gly Leu Ala Gly Gly Arg Ile Val Leu Ala Leu
        1395                1400                1405            
 Glu Gly Gly His Asp Leu Thr Ala Ile Cys Asp Ala Ser Glu Ala Cys
    1410                1415                1420                
 Val Ser Ala Leu Leu Gly Asn Glu Cys Lys Pro His Tyr Glu Arg Asn
1425                1430                1435                1440
 Pro Thr Gly His Ser Gln Phe Pro Pro Pro Pro Pro Leu Pro Ser Val
                1445                1450                1455    
 Pro Gly Lys Gln Val Ala Phe Gln Thr Val Gly Asn Ser Leu Leu Thr
            1460                1465                1470        
 Gly Cys Cys Phe Ser Arg Gly Ser Gln Lys Val Leu Gln Gln Arg Pro
        1475                1480                1485            
 Asn Ala Asn Ala Val Arg Ser Met Glu Lys Val Met Glu Ile His Ser
    1490                1495                1500                
 Lys Tyr Trp Arg Cys Leu Gln Arg Thr Thr Ser Thr Ala Gly Arg Ser
1505                1510                1515                1520
 Leu Ile Glu Ala Gln Thr Cys Glu Asn Glu Glu Ala Glu Thr Val Thr
                1525                1530                1535    
 Ala Met Ala Ser Leu Ser Val Gly Val Lys Pro Ala Glu Lys Arg Cys
            1540                1545                1550        
 Pro Pro Val Gln Val Glu Thr Ala Ala Leu Leu Leu Gln Lys Lys Gly
        1555                1560                1565            
 Arg Val Gly Thr Glu Arg His Gln Ser Leu Cys His Arg Thr Lys Asn
    1570                1575                1580                
 Thr Cys Lys Pro Tyr Gln His Met Arg Asn His Cys Thr Gln Val Pro
1585                1590                1595                1600
 His Asn Pro Gln Gly Leu Pro Met Arg Ser Thr Leu Tyr Leu Lys Asp
                1605                1610                1615    
 Ile Cys Ala Ser Gly Lys Ala Glu Gly Gln Gly Trp Cys Cys Leu Asp
            1620                1625                1630        
 Ser Leu Glu Ala Ile Val Gly Ala Phe Pro Arg Glu Glu Gly Gly Thr
        1635                1640                1645            
 His Arg Ser Lys Phe Pro Arg Leu Tyr Arg Lys His Glu Ala Gly Ile
    1650                1655                1660                
 Cys Ser Ala Ser Gly Glu Ala Ser Gly Asn Val Gln Leu Trp Gln Lys
1665                1670                1675                1680
 Gly Lys Gln Ile Leu Ala Glu Thr Val Ser His Thr His Met Pro Thr
                1685                1690                1695    
 Ala Thr Glu Leu Arg Val Leu Pro Arg Ala Phe Cys Pro Gln Lys Arg
            1700                1705                1710        
 Ile Arg Leu Ala Ser Val Gln Leu Ser Ser Ala His Ala Asp Thr Glu
        1715                1720                1725            
 His Met Leu His Thr Ser Gly Pro Thr Ala Val Leu Glu Thr Ser Ile
    1730                1735                1740                
 Thr Leu Thr Ala Ser Met Gly Lys Pro Ala Pro Ser Cys Arg Leu Gly
1745                1750                1755                1760
 Ser Leu Lys Ala Gln Thr Ser Ser Cys Leu Gln Ala Phe Ala Gln Ala
                1765                1770                1775    
 Val Pro Pro Pro Gly Ile Pro Phe Pro Thr Trp
            1780                1785        



      <210> 1663
      <211> 103
      <212> PRT
      <213> Homo sapiens


      <400> 1663
 Met Leu Gln Gly His Ser Ser Val Phe Gln Ala Leu Leu Gly Thr Phe
   1               5                  10                  15    
 Phe Thr Trp Gly Met Thr Ala Ala Gly Ala Ala Leu Val Phe Val Phe
              20                  25                  30        
 Ser Ser Gly Gln Val Ser Cys Leu Ala Leu Val Leu Asp Val Gly Gly
          35                  40                  45            
 Glu Pro Val Gly Lys Gly Ala Leu Ser His Ser Met Glu Gln Val Cys
      50                  55                  60                
 Arg Leu Phe Ser Ala Pro Gly His Thr Pro Arg His Cys Val Leu Gly
  65                  70                  75                  80
 Phe Val Arg Cys Leu Leu Ile Phe Ser Pro Ser Pro Cys Gln Ala Gly
                  85                  90                  95    
 Arg Thr Asp Val Cys Leu Leu
             100            



      <210> 1664
      <211> 375
      <212> PRT
      <213> Homo sapiens


      <400> 1664
 Met Ile Val Val Ile Leu Phe Val Val Ala Asn Gly Leu Val Gln Val
   1               5                  10                  15    
 Gly Val Leu Asp Asn Gly Glu Gln Arg Leu Gln Ser Tyr Ser Tyr Val
              20                  25                  30        
 Asn Leu Ser Ala Cys Lys Ser Ala Tyr Ser Leu Ile Ile Asp Val Ser
          35                  40                  45            
 Asp Ser Leu Lys Gly Asp Thr Gly Cys Ala Gly Phe Ser Asp Leu Gln
      50                  55                  60                
 Lys Ile Asn Val Ser Lys Tyr Pro Lys Leu Thr Trp Gly Phe Gln Asp
  65                  70                  75                  80
 Tyr Ala Ala Arg Lys Val Gly Val Arg Pro Leu Ala Asn Arg Arg Ala
                  85                  90                  95    
 Leu Thr Asn Pro Tyr Thr Ala Arg His Ile Lys Tyr Leu Tyr Ser Glu
             100                 105                 110        
 Lys Ala Thr Leu Ser Thr Glu Phe Phe Leu Leu Arg Arg Gln Glu Phe
         115                 120                 125            
 Arg Leu Leu Gln Thr Arg Pro Asp Leu Pro Leu Val Ala Gln Ile Thr
     130                 135                 140                
 Ser Ala Ala Gly Asn Lys Phe Val His Glu Ala Arg Met Arg Lys Val
 145                 150                 155                 160
 Lys Thr Leu Asp Phe Phe Pro Phe Leu Val Trp Leu Asn Lys Leu Leu
                 165                 170                 175    
 Leu Pro Asp Thr Leu Gly Asp Asn Thr Tyr Lys Leu Trp Gly Lys Lys
             180                 185                 190        
 Ile Gln Arg Asp Asn Asp Ser Lys Pro Gly Tyr Glu Ala Leu Asn Pro
         195                 200                 205            
 Ile Pro Val Arg Leu Asp Asn Glu Ala Leu Asn Ala Ile Ser Ala Leu
     210                 215                 220                
 Asn Ser Ala Phe Leu Ser Met His Gln Ala Pro Gln Lys Ser Asp Leu
 225                 230                 235                 240
 Gln Ser Val His Gln Pro Gly Thr Gln Ala Leu Gln Ser Met His Gln
                 245                 250                 255    
 Pro Gly Thr Gln Ala Leu Gln Ser Met Gln Gln Pro Gly Val Gln Ala
             260                 265                 270        
 Ser Glu Arg Pro Ala Gln Gln Ala Thr Ala Arg Gln Pro Gly Leu Lys
         275                 280                 285            
 Ala Leu Asn Phe Ser Ser Ile Gln Asn Ser Asn Phe Leu Ser Ala Ser
     290                 295                 300                
 Gly Pro Val Thr Thr Ala Val Thr Thr His Lys Gln Gln Val Thr Tyr
 305                 310                 315                 320
 Leu Pro Asp Asn Asp Thr Pro Leu Met Arg Ala Ile Ser Gln Ala Arg
                 325                 330                 335    
 Glu Tyr Gly Asp Pro Glu Ala Trp Gln Phe Pro Val Ile Leu Gln Ser
             340                 345                 350        
 Ala Ile Pro Ala Ala Ser Ile Pro Ala Ala Pro Ala Pro Ala Gly Cys
         355                 360                 365            
 Thr Ser Ser Ala Thr Ala Leu
     370                 375



      <210> 1665
      <211> 101
      <212> PRT
      <213> Homo sapiens


      <400> 1665
 Met His Trp Leu Cys Val Ser Cys Ile Phe Thr Cys Leu Pro Gly Trp
   1               5                  10                  15    
 Arg Pro Ala Ala Pro Asp Gln Gly Pro Ala Ala Ile Ser Leu Cys Ser
              20                  25                  30        
 Leu Pro Ser Ser Ser Gln Gly His Arg Glu Pro Leu Ala Leu Gly Leu
          35                  40                  45            
 Pro Ser Ala Leu Pro Pro Ala His Arg Gln Arg Leu Arg Gly Ser Ala
      50                  55                  60                
 Thr Leu Arg Val Val Pro Gln Pro Pro Val Leu Gly Ser Cys Ser Ala
  65                  70                  75                  80
 Glu Gly Cys Leu Gly Asp Gly Arg Ala Pro Pro Ala Ala Gly Ala Ser
                  85                  90                  95    
 Cys Gly Pro Arg Pro
             100    



      <210> 1666
      <211> 151
      <212> PRT
      <213> Homo sapiens


      <400> 1666
 Met Arg Ala Ser Ser Phe Leu Ile Val Val Val Phe Leu Ile Ala Gly
   1               5                  10                  15    
 Thr Leu Val Leu Glu Ala Ala Val Thr Gly Val Pro Val Lys Gly Gln
              20                  25                  30        
 Asp Thr Val Lys Gly Arg Val Pro Phe Asn Gly Gln Asp Pro Val Lys
          35                  40                  45            
 Gly Gln Val Ser Val Lys Gly Gln Asp Lys Val Lys Ala Gln Glu Pro
      50                  55                  60                
 Val Lys Gly Pro Val Ser Thr Lys Pro Gly Ser Cys Pro Ile Ile Leu
  65                  70                  75                  80
 Ile Arg Cys Ala Met Leu Asn Pro Pro Asn Arg Cys Leu Lys Asp Thr
                  85                  90                  95    
 Asp Cys Pro Gly Ile Lys Lys Cys Cys Glu Gly Ser Cys Gly Met Ala
             100                 105                 110        
 Cys Phe Val Pro Gln Cys Asp Leu Thr Arg Gln Leu Ala Phe Leu Thr
         115                 120                 125            
 Leu Ser Gln Pro Leu Arg Thr Leu Ser Leu Leu Asp Asn Pro Thr Cys
     130                 135                 140                
 Lys Thr Gln Leu Thr Asp Phe
 145                 150    



      <210> 1667
      <211> 199
      <212> PRT
      <213> Homo sapiens


      <400> 1667
 Met Lys Gly Ser Pro Phe Gly Trp Gln Pro His Phe Ser Ile Ala Thr
   1               5                  10                  15    
 Phe Thr His Val Phe Ser Thr Arg Phe Arg Leu Met Leu Cys Ser Ala
              20                  25                  30        
 Cys Cys Ala Cys Cys Glu Gly Asn Lys Asp Arg Ala Val Arg Leu Glu
          35                  40                  45            
 Val Leu Phe Tyr Phe Ser Cys Ile Asp Leu Ile His Asp Trp Cys Leu
      50                  55                  60                
 Pro Leu Arg Ser Val Leu Leu Lys Arg Gly Val Ala Lys Val Gly Asp
  65                  70                  75                  80
 Ile Ala Ser Val Leu Glu Phe Gly Lys Ser Leu Arg Arg Asp Leu Leu
                  85                  90                  95    
 Ser Phe Ala Val Val Ile Val Asp Pro Val Thr Phe Lys Asp Val Ala
             100                 105                 110        
 Val Asp Phe Thr Gln Glu Glu Trp Gly Gln Leu Asp Leu Val Gln Arg
         115                 120                 125            
 Thr Leu Tyr Arg Asp Val Met Leu Glu Thr Tyr Gly His Leu Leu Ser
     130                 135                 140                
 Val Gly Asn Gln Ile Ala Lys Pro Glu Val Ile Ser Leu Leu Glu Gln
 145                 150                 155                 160
 Gly Glu Glu Pro Trp Ser Val Glu Gln Ala Cys Pro Gln Arg Thr Cys
                 165                 170                 175    
 Pro Ala Lys Pro Thr Pro Thr Ile Phe Glu Ala Gln Gln Pro Phe Val
             180                 185                 190        
 Glu Ile Tyr Asp Ala Cys Lys
         195                



      <210> 1668
      <211> 244
      <212> PRT
      <213> Homo sapiens


      <400> 1668
 Met Gly Leu Asp Ser Gly Thr Ala Trp Leu Cys Ser Ile Trp Leu Val
   1               5                  10                  15    
 Leu Lys Asp Thr Val Thr Val Cys Glu Leu Leu Gly His Ala Pro Gly
              20                  25                  30        
 Trp Glu Pro His Thr Gly Met Gln Phe Tyr Ser Leu Ser Tyr Glu Gly
          35                  40                  45            
 Thr Trp Met Lys Leu Glu Thr Ile Ile Leu Ser Lys Leu Leu Gln Gly
      50                  55                  60                
 Gln Lys Thr Arg His Arg Met Phe Ser Leu Ile Asp Lys Leu Asn Ser
  65                  70                  75                  80
 Lys Leu Ala Arg Val Gly Ser Gln Pro Ala Thr Tyr Phe Pro Thr Glu
                  85                  90                  95    
 Asn Pro Gln Arg Leu Arg Asn Gly Gln Asp Gln Val Pro Val Thr Val
             100                 105                 110        
 Gly Ala Lys Glu Gly Leu Leu Lys Lys Leu Leu Trp Thr Glu Leu Cys
         115                 120                 125            
 Ser Leu Pro Asn Ser Tyr Thr Glu Asn Pro Thr Pro Asn Leu Phe Trp
     130                 135                 140                
 Cys Lys Ser His Thr Val Glu Ala Pro Pro Ile Phe Val Pro Ser Asn
 145                 150                 155                 160
 Pro Val Leu Ser Gln Arg Trp Pro Leu Leu Ala Leu Gly Leu Ser Ala
                 165                 170                 175    
 Leu Pro Pro Pro Pro Pro Phe Ala Ile Phe Gln Pro Cys Gly Val Thr
             180                 185                 190        
 Asp Ser Ser Val Ser His Ile Met Leu Leu Cys Val Ser Ala Pro Val
         195                 200                 205            
 Pro Glu Phe Leu Trp Pro Phe Trp Thr Leu Phe Leu Arg Gly Ser Ser
     210                 215                 220                
 Ile Asn Pro Thr Ile Leu Pro Ala Thr Asp Val Thr Thr Pro Ala Gln
 225                 230                 235                 240
 Thr Ala Ala Pro
                



      <210> 1669
      <211> 157
      <212> PRT
      <213> Homo sapiens


      <400> 1669
 Met Leu Cys Glu Gly Arg Asp Cys Val Cys Thr Val Leu Phe Arg Thr
   1               5                  10                  15    
 Phe Ile Asn Leu Cys Cys Asn Cys Leu Pro Asn Gly Phe Leu Pro Cys
              20                  25                  30        
 Leu Leu Cys Phe Leu Ser Ile Lys Thr Leu Phe Phe Leu Phe Leu Glu
          35                  40                  45            
 Glu Phe Cys Ser Gln Tyr Ile Val Leu Val Asn Gly Arg Thr Ala Thr
      50                  55                  60                
 Ile Asp Trp Phe Ser His Ile Pro Asp Ser Gln Asn Leu Ile Gly Ser
  65                  70                  75                  80
 His Trp Gln Arg Arg Asn Glu Val Phe Gln Ile Ser Thr Gln His Ser
                  85                  90                  95    
 Arg Thr Ala Tyr Arg Arg Val Gly Val Glu Cys Val Leu Phe Pro Ser
             100                 105                 110        
 Leu Cys Pro Cys Val Leu Ile Val Gln Leu Pro Leu Ile Ser Glu Asn
         115                 120                 125            
 Met Gln Cys Leu Leu Phe Cys Ser Cys Val Ser Leu Leu Lys Ile Ile
     130                 135                 140                
 Ala Ser Ser Ser Phe His Val Pro Ile Pro Pro Glu Asp
 145                 150                 155        



      <210> 1670
      <211> 120
      <212> PRT
      <213> Homo sapiens


      <400> 1670
 Met Ile Ala Cys Arg Ala Leu Thr Val Leu Thr Trp Thr His Val Arg
   1               5                  10                  15    
 Ile Asp Glu Gly His Val Pro Ala Met Phe Ala Gln Ser Ser Val Phe
              20                  25                  30        
 Arg Glu Leu Ile Thr Gly Val Ala Lys Ala Thr Gly Ala Thr His Leu
          35                  40                  45            
 Leu Ser Cys Phe Gln Asp Glu Glu Val Gln Thr Ile Gly Gln Ile Glu
      50                  55                  60                
 Leu Cys Leu Thr Lys Gln Asp Gln Gln Leu Gln Asn Cys Thr Glu Pro
  65                  70                  75                  80
 Gly Glu Gln Pro Ser Pro Lys Gln Glu Val Trp Leu Ala Asn Gly Ala
                  85                  90                  95    
 Ala Glu Ser Arg Gly Leu Arg Val Cys Glu Asp Gly Pro Val Phe Tyr
             100                 105                 110        
 Pro Pro Pro Lys Lys Thr Lys His
         115                 120



      <210> 1671
      <211> 336
      <212> PRT
      <213> Homo sapiens


      <400> 1671
 Met Trp Arg Ser Arg Trp Asp Ala Ser Val Leu Lys Ala Glu Ala Leu
   1               5                  10                  15    
 Ala Leu Leu Pro Cys Gly Leu Gly Met Ala Phe Ser Gln Ser His Val
              20                  25                  30        
 Met Ala Ala Arg Arg His Gln His Ser Arg Leu Ile Ile Glu Val Asp
          35                  40                  45            
 Glu Tyr Ser Ser Asn Pro Thr Gln Ala Phe Thr Phe Tyr Asn Ile Asn
      50                  55                  60                
 Gln Gly Arg Phe Gln Pro Pro His Val Gln Ile Pro Cys Ala Ser Leu
  65                  70                  75                  80
 Val Lys Ala Glu Met Leu Phe Gln Lys Asp Trp Gly Ile Leu Leu Ser
                  85                  90                  95    
 Ala Pro Arg Gly Ile Gly Gly Ala Gln Ala Val Arg Pro Trp Gly Ala
             100                 105                 110        
 His Arg Leu Lys Ala Pro Val Asn Val Asp Thr Leu Ser Thr Asp Glu
         115                 120                 125            
 Asp Ala Lys Val Leu Glu Gly Ala Gly Cys Ile Val Ile Val Trp Pro
     130                 135                 140                
 Asn Leu Leu Pro Pro Ser Val Pro Gly Leu Val Gly Leu Tyr Phe Thr
 145                 150                 155                 160
 His Ser Pro Glu Thr Pro Pro Pro Val Leu Leu Ser Cys Asp Gly Gly
                 165                 170                 175    
 Arg Ala Leu His Ser Pro Gly Ser Arg Pro His Arg Pro Thr Thr Gly
             180                 185                 190        
 Phe Thr Pro Cys Gly Leu Ser Gly Gly His Ser Ala Pro Lys Gly Val
         195                 200                 205            
 Asp Pro Val Pro His Asp Ala Pro Lys Pro Pro Gly Tyr Thr Arg Phe
     210                 215                 220                
 Val Cys Val Ser Asp Thr His Ser Arg Thr Asp Pro Ile Gln Met Pro
 225                 230                 235                 240
 Tyr Gly Asp Val Leu Ile His Ala Gly Asp Phe Thr Glu Leu Gly Leu
                 245                 250                 255    
 Pro Ser Glu Val Lys Lys Phe Asn Glu Trp Leu Asp Glu Glu Thr Glu
             260                 265                 270        
 Ala Gln Cys Gly Glu Val Val Ser Gly Gly His Ala Gly Leu Gln Gly
         275                 280                 285            
 Arg Asp Leu Asp Arg Gln Lys Lys Asp Phe Thr Pro Phe Gly Val Cys
     290                 295                 300                
 Thr Met Gln Met Lys Ile Arg Glu Leu Ala Glu Gly Arg Leu Glu Leu
 305                 310                 315                 320
 Ile Leu Gly Trp Phe Asp Ser His Asp Thr Glu Gly Glu Ala Ser Ser
                 325                 330                 335    





      <210> 1672
      <211> 443
      <212> PRT
      <213> Homo sapiens


      <400> 1672
 Met Ala Leu Thr Gly Tyr Ser Trp Leu Leu Leu Ser Ala Thr Phe Leu
   1               5                  10                  15    
 Asn Val Gly Ala Glu Ile Ser Ile Thr Leu Glu Pro Ala Gln Pro Ser
              20                  25                  30        
 Glu Gly Asp Asn Val Thr Leu Val Val His Gly Leu Ser Gly Glu Leu
          35                  40                  45            
 Leu Ala Tyr Ser Trp Tyr Ala Gly Pro Thr Leu Ser Val Ser Tyr Leu
      50                  55                  60                
 Val Ala Ser Tyr Ile Val Ser Thr Gly Asp Glu Thr Pro Gly Pro Ala
  65                  70                  75                  80
 His Thr Gly Arg Glu Ala Val Arg Pro Asp Gly Ser Leu Asp Ile Gln
                  85                  90                  95    
 Gly Ile Leu Pro Arg His Ser Gly Thr Tyr Ile Leu Gln Thr Phe Asn
             100                 105                 110        
 Arg Gln Leu Gln Thr Glu Val Gly Tyr Gly His Val Gln Val His Glu
         115                 120                 125            
 Ile Leu Ala Gln Pro Thr Val Leu Ala Asn Ser Thr Ala Leu Val Glu
     130                 135                 140                
 Arg Arg Asp Thr Leu Arg Leu Met Cys Ser Ser Pro Ser Pro Thr Ala
 145                 150                 155                 160
 Glu Val Arg Trp Phe Phe Asn Gly Gly Ala Leu Pro Val Ala Leu Arg
                 165                 170                 175    
 Leu Gly Leu Ser Pro Asp Gly Arg Val Leu Ala Arg His Gly Ile Arg
             180                 185                 190        
 Arg Glu Glu Ala Gly Ala Tyr Gln Cys Glu Val Trp Asn Pro Val Ser
         195                 200                 205            
 Val Ser Arg Ser Glu Pro Ile Asn Leu Thr Val Tyr Phe Gly Pro Glu
     210                 215                 220                
 Arg Val Ala Ile Leu Gln Asp Ser Thr Thr Arg Thr Gly Cys Thr Ile
 225                 230                 235                 240
 Lys Val Asp Phe Asn Thr Ser Leu Thr Leu Trp Cys Val Ser Arg Ser
                 245                 250                 255    
 Cys Pro Glu Pro Glu Tyr Val Trp Thr Phe Asn Gly Gln Ala Leu Lys
             260                 265                 270        
 Asn Gly Gln Asp His Leu Asn Ile Ser Ser Met Thr Ala Ala Gln Glu
         275                 280                 285            
 Gly Thr Tyr Thr Cys Ile Ala Lys Asn Thr Lys Thr Leu Leu Ser Gly
     290                 295                 300                
 Ser Ala Ser Val Val Val Lys Leu Ser Ala Ala Ala Val Ala Thr Met
 305                 310                 315                 320
 Ile Val Pro Val Pro Thr Lys Pro Thr Glu Gly Gln Asp Val Thr Leu
                 325                 330                 335    
 Thr Val Gln Gly Tyr Pro Lys Asp Leu Leu Val Tyr Ala Trp Tyr Arg
             340                 345                 350        
 Gly Pro Ala Ser Glu Pro Asn Arg Leu Leu Ser Gln Leu Pro Ser Gly
         355                 360                 365            
 Thr Trp Ile Ala Gly Pro Ala His Thr Gly Arg Glu Val Gly Phe Pro
     370                 375                 380                
 Asn Cys Ser Leu Leu Val Gln Lys Leu Asn Leu Thr Asp Thr Gly Arg
 385                 390                 395                 400
 Tyr Thr Leu Lys Thr Val Thr Val Gln Gly Lys Thr Glu Thr Leu Glu
                 405                 410                 415    
 Val Glu Leu Gln Val Ala Leu Asn Leu Pro Pro Ser His Lys Asp Gln
             420                 425                 430        
 Arg Tyr Leu Pro Glu Pro Glu Pro Gly Thr Gly
         435                 440            



      <210> 1673
      <211> 1140
      <212> PRT
      <213> Homo sapiens


      <400> 1673
 Met Val Cys Cys Phe Tyr Thr Arg Pro Leu Ile Leu Leu Thr Ala Ser
   1               5                  10                  15    
 Thr Thr Thr Ala Leu Gly Gln Ala Leu Met Ile Asp Arg Lys Met Ser
              20                  25                  30        
 Ser Thr His Thr Ser Tyr Lys Leu Asp Glu Ala Gln Ala Ile Met Ser
          35                  40                  45            
 Glu Leu Arg Thr Ile Lys Lys Ala Ile Cys Thr Gly Glu Lys Glu Arg
      50                  55                  60                
 Arg Asp Leu Met His Ser Leu Ala Lys Leu Thr Asp Ser Phe Lys Asn
  65                  70                  75                  80
 Ser Cys Ser Val Thr Asp Ser Leu Val Asp Phe Pro His His Val Gly
                  85                  90                  95    
 Val Pro Gly Asp Ala Gly Val Pro Gln Gln Phe Cys Asp Ala Gly Ser
             100                 105                 110        
 Gln Thr Asp Ile Ile Gly Glu Phe Val Phe Asp Asp Lys Thr Arg Leu
         115                 120                 125            
 Val Asp Arg Val Arg Leu Asn Trp Gln Tyr Glu Glu Ala Arg Lys Arg
     130                 135                 140                
 Val Ala Asn Ile Gln Gln Gln Leu Ala Arg Leu Asp Asn Glu Ser Trp
 145                 150                 155                 160
 Pro Ser Thr Ala Glu Ala Asp Arg Asp Arg Leu Gln Leu Ile Lys Glu
                 165                 170                 175    
 Lys Glu Ala Leu Leu Gln Glu Leu Gln Leu Ile Ile Ala Gln Arg Arg
             180                 185                 190        
 Ser Ala Gly Asp Val Ala Arg Leu Glu Glu Glu Arg Glu Arg Leu Glu
         195                 200                 205            
 Glu Glu Leu Arg Arg Ala Arg Ala Thr Ser Ala Gln Gly Ala Thr Glu
     210                 215                 220                
 Arg Ile Leu Leu Gln Glu Lys Arg Asn Cys Leu Leu Met Gln Leu Glu
 225                 230                 235                 240
 Glu Ala Thr Arg Leu Thr Ser Tyr Leu Gln Ser Gln Leu Lys Ser Leu
                 245                 250                 255    
 Cys Ala Ser Thr Leu Thr Val Ser Ser Gly Ser Ser Arg Gly Ser Leu
             260                 265                 270        
 Ala Ser Ser Arg Gly Ser Leu Ala Ser Ser Arg Gly Ser Leu Ser Ser
         275                 280                 285            
 Val Ser Phe Thr Asp Ile Tyr Gly Leu Pro Gln Tyr Glu Lys Pro Asp
     290                 295                 300                
 Ala Glu Gly Ser Gln Leu Leu Arg Phe Asp Leu Ile Pro Phe Asp Ser
 305                 310                 315                 320
 Leu Gly Arg Asp Ala Pro Phe Ser Glu Pro Pro Gly Pro Ser Gly Phe
                 325                 330                 335    
 His Lys Gln Arg Arg Ser Leu Asp Thr Pro Gln Ser Leu Ala Ser Leu
             340                 345                 350        
 Ser Ser Arg Ser Ser Leu Ser Ser Leu Ser Pro Pro Ser Ser Pro Leu
         355                 360                 365            
 Asp Thr Pro Phe Leu Pro Ala Ser Arg Asp Ser Pro Leu Ala Gln Leu
     370                 375                 380                
 Ala Asp Ser Cys Glu Gly Pro Gly Leu Gly Ala Leu Asp Arg Leu Arg
 385                 390                 395                 400
 Ala His Ala Ser Ala Met Gly Asp Glu Asp Leu Pro Gly Met Ala Ala
                 405                 410                 415    
 Leu Gln Pro His Gly Val Pro Gly Asp Gly Glu Gly Pro His Glu Arg
             420                 425                 430        
 Gly Pro Pro Pro Ala Ser Ala Pro Val Gly Gly Thr Val Thr Leu Arg
         435                 440                 445            
 Glu Asp Ser Ala Lys Arg Leu Glu Arg Arg Ala Arg Arg Ile Ser Ala
     450                 455                 460                
 Cys Leu Ser Asp Tyr Ser Leu Ala Ser Asp Ser Gly Val Phe Glu Pro
 465                 470                 475                 480
 Leu Thr Lys Arg Asn Glu Asp Ala Glu Glu Pro Ala Tyr Gly Asp Thr
                 485                 490                 495    
 Ala Ser Asn Gly Asp Pro Gln Ile His Val Gly Leu Leu Arg Asp Ser
             500                 505                 510        
 Gly Ser Glu Cys Leu Leu Val His Val Leu Gln Leu Lys Asn Pro Ala
         515                 520                 525            
 Gly Leu Ala Val Lys Glu Asp Cys Lys Val His Ile Arg Val Tyr Leu
     530                 535                 540                
 Pro Pro Leu Asp Ser Gly Thr Pro Asn Thr Tyr Cys Ser Lys Ala Leu
 545                 550                 555                 560
 Glu Phe Gln Val Pro Leu Val Phe Asn Glu Val Phe Arg Ile Pro Val
                 565                 570                 575    
 His Ser Ser Ala Leu Thr Leu Lys Ser Leu Gln Leu Tyr Val Cys Ser
             580                 585                 590        
 Val Thr Pro Gln Leu Gln Glu Glu Leu Leu Gly Ile Ala Gln Ile Asn
         595                 600                 605            
 Leu Ala Asp Tyr Asp Ser Leu Ser Glu Met Gln Leu Arg Trp His Ser
     610                 615                 620                
 Val Gln Val Phe Thr Ser Ser Glu Pro Ser Arg Thr Arg Glu Ala Gly
 625                 630                 635                 640
 Cys Ala Gly Glu Ser Ser Ala Arg Asp Pro Ala His Thr Ile Ser Ile
                 645                 650                 655    
 Ser Gly Lys Thr Asp Ala Val Thr Val Leu Leu Ala Arg Thr Thr Ala
             660                 665                 670        
 Gln Leu Gln Ala Val Glu Arg Glu Leu Ala Glu Glu Arg Ala Lys Leu
         675                 680                 685            
 Glu Tyr Thr Glu Glu Glu Val Leu Glu Met Glu Arg Lys Glu Glu Gln
     690                 695                 700                
 Ala Glu Ala Ile Ser Glu Arg Ser Trp Gln Ala Asp Ser Val Asp Ser
 705                 710                 715                 720
 Gly Cys Ser Asn Cys Thr Gln Thr Ser Pro Pro Tyr Pro Glu Pro Cys
                 725                 730                 735    
 Cys Met Gly Ile Asp Ser Ile Leu Gly His Pro Phe Ala Ala Gln Ala
             740                 745                 750        
 Gly Pro Tyr Ser Pro Glu Lys Phe Gln Pro Ser Pro Leu Lys Val Asp
         755                 760                 765            
 Lys Glu Thr Asn Thr Glu Asp Leu Phe Leu Glu Glu Ala Ala Ser Leu
     770                 775                 780                
 Val Lys Glu Arg Pro Ser Arg Arg Ala Arg Gly Ser Pro Phe Val Arg
 785                 790                 795                 800
 Ser Gly Thr Ile Val Arg Ser Gln Thr Phe Ser Pro Gly Ala Arg Ser
                 805                 810                 815    
 Gln Tyr Val Cys Arg Val Arg Pro Gly Arg Gln Asn Phe Arg Lys His
             820                 825                 830        
 Pro Asp Gly Ser Ser Met Ser His Lys Ala Glu Asn Pro Lys Val Gly
         835                 840                 845            
 Arg Gly Lys Met Arg Ala Ser Val Val Asn Glu Ala Ala Leu Thr Gly
     850                 855                 860                
 Asp Ala Ser Gly Cys Phe Ala Val Leu Tyr Val Cys Met Asn Ala Val
 865                 870                 875                 880
 Gln Leu Tyr Arg Ser Asp Ser Asp Ser Ser Thr Leu Pro Arg Lys Ser
                 885                 890                 895    
 Pro Phe Val Arg Asn Thr Leu Glu Arg Arg Thr Leu Arg Tyr Lys Gln
             900                 905                 910        
 Ser Cys Arg Ser Ser Leu Ala Glu Leu Met Ala Arg Thr Ser Leu Asp
         915                 920                 925            
 Leu Glu Leu Asp Leu Gln Ala Ser Arg Thr Arg Gln Arg Gln Leu Asn
     930                 935                 940                
 Glu Glu Leu Cys Ala Leu Arg Glu Leu Arg Gln Arg Leu Glu Asp Ala
 945                 950                 955                 960
 Gln Leu Arg Gly Gln Thr Asp Leu Pro Pro Trp Val Leu Arg Asp Glu
                 965                 970                 975    
 Arg Leu Arg Gly Leu Leu Arg Glu Ala Glu Arg Gln Thr Arg Gln Thr
             980                 985                 990        
 Lys Leu Asp Tyr Arg His Glu Gln Ala Ala Glu Lys Met Leu Lys Lys
         995                1000                1005            
 Ala Ser Lys Glu Ile Tyr Gln Leu Arg Gly Gln Ser His Lys Glu Pro
    1010                1015                1020                
 Ile Gln Val Gln Thr Phe Ser Gly Ser Ile Val Thr Arg Lys His Val
1025                1030                1035                1040
 Cys Val Ala Glu Leu Asn Ala Ala Met Thr Arg Lys Glu Lys Thr Lys
                1045                1050                1055    
 Glu Gly Gln Arg Ala Ala Gln Phe Ser Ala Gly Ala Asp Ala Gly Ser
            1060                1065                1070        
 Gly Gly Gly Leu Ser Arg Gln Lys Asp Thr Lys Arg Pro Met Leu Leu
        1075                1080                1085            
 Val Ile His Asp Val Val Leu Glu Leu Leu Thr Ser Ser Asp Cys His
    1090                1095                1100                
 Ala Asn Pro Arg Lys Tyr Pro Thr Cys Gln Lys Asn Pro Gln Pro Lys
1105                1110                1115                1120
 Gly Ala Gly Asp Phe Gly Ser Val Leu Thr Leu Ser Gln Asn Leu Lys
                1125                1130                1135    
 Ala Glu Gly Leu
            1140



      <210> 1674
      <211> 397
      <212> PRT
      <213> Homo sapiens


      <400> 1674
 Met Val Glu Leu Val Tyr Ser Pro Ile Asn Cys Val Lys Val Phe Leu
   1               5                  10                  15    
 Phe Leu His Ile Leu Ser Ser Thr Cys Ser Ser His Trp Gly Val Ser
              20                  25                  30        
 Asp Ser Gly Cys Arg Thr Val Gly Ala Ala His Arg Ser Gln Leu Asp
          35                  40                  45            
 Glu Trp Leu Thr Lys Ile Thr Asn Ala Glu Lys Ser Leu Lys Asp Leu
      50                  55                  60                
 Met Glu Leu Lys Thr Thr Ala Arg Glu Leu Arg Asp Glu Cys Thr Ser
  65                  70                  75                  80
 Leu Arg Ser Gln Phe Asn Gln Leu Glu Glu Arg Val Ser Val Met Glu
                  85                  90                  95    
 Asp Gln Met Asn Glu Met Lys Arg Glu Glu Lys Phe Arg Glu Lys Arg
             100                 105                 110        
 Ile Lys Arg Asn Lys Gln Ser Leu Gln Glu Ile Trp Asp Tyr Val Lys
         115                 120                 125            
 Arg Pro Asn Leu Arg Leu Ile Gly Val Pro Glu Ser Asp Gly Glu Asn
     130                 135                 140                
 Gly Thr Lys Leu Glu Asn Thr Leu Gln Asp Ile Ile Gln Glu Asn Phe
 145                 150                 155                 160
 Pro Asn Gln Ala Arg Gln Ala Asn Ile Gln Ile Gln Lys Ile Gln Arg
                 165                 170                 175    
 Thr Pro Gln Arg Tyr Ser Ser Arg Arg Ala Thr Pro Arg His Ile Ile
             180                 185                 190        
 Val Ser Phe Thr Lys Val Glu Met Lys Glu Lys Lys Gly Asn Pro Gly
         195                 200                 205            
 Val Ser Leu Glu Leu Arg Leu Thr Lys Pro Gly Cys Thr Leu Val Gln
     210                 215                 220                
 Pro Glu Glu Val Leu Ser Glu Ser Gln Ser Leu Arg Trp Asp Pro Gly
 225                 230                 235                 240
 Ser Arg Thr Phe Gln Ser Ala Thr Thr Gly Ala Asp Val Gln Gly Tyr
                 245                 250                 255    
 Met Ala Leu Glu Leu Val Leu Ala Gly Lys Ala Trp Asp Lys Ala Ser
             260                 265                 270        
 Leu Gly Gly Leu Arg Ser Ala Ala Gly Arg Lys Leu Ser Ser Pro Pro
         275                 280                 285            
 Ser Leu Arg Trp Val Leu Leu Leu Phe Val Thr Val Pro Ser Arg Gly
     290                 295                 300                
 Glu Leu Gly His Leu Gly Gln Val Phe Val Gly Gly Ser Ala Pro Cys
 305                 310                 315                 320
 Leu Ala Gln Arg Glu Val Lys Glu Ala Leu Gly Gln Pro Asp Ser Ala
                 325                 330                 335    
 Ala Ala Arg Val Gln Ser Pro Arg Leu Gly Arg Trp Thr Pro Ala Ala
             340                 345                 350        
 Ser Pro Pro Leu Arg Thr Arg His Val Arg Ala Ser His Gly Arg Gly
         355                 360                 365            
 Pro Ser Gln Thr Thr Pro Arg Pro Pro Pro Ala Arg Pro Gln Pro Pro
     370                 375                 380                
 His Arg Leu Asp Thr Arg Gly Ser Arg Val Leu Ile Gly
 385                 390                 395        



      <210> 1675
      <211> 111
      <212> PRT
      <213> Homo sapiens


      <400> 1675
 Met Phe Leu Ser Pro Val Leu Phe Leu Ser Val Arg Thr Val Phe Thr
   1               5                  10                  15    
 Phe Val Lys Leu Arg Asn Phe Leu Leu Asp Leu Ala Arg Ser Ile Arg
              20                  25                  30        
 Ile Thr Cys Gly Pro Trp Thr Leu Leu Tyr Gln Leu Pro Ala Ala Ala
          35                  40                  45            
 Gly Thr Ser Ser Phe Trp Pro Leu Ser Val Pro Gly Cys Pro Cys Cys
      50                  55                  60                
 Cys Arg Ala Cys Trp Glu Phe Thr Ser Leu Val Pro Leu Val Gly Arg
  65                  70                  75                  80
 Cys Gln Val Ala Gly Ser Leu Val Phe Ser Ser Ser Ser Phe Cys Leu
                  85                  90                  95    
 Gln Lys Gln Phe Gln Glu Pro Leu Tyr Thr Thr Ser Ala Ala Thr
             100                 105                 110    



      <210> 1676
      <211> 146
      <212> PRT
      <213> Homo sapiens


      <400> 1676
 Met Ser Thr Leu Tyr Glu Ile Phe Pro Ser Ser Val Pro Gly Phe Tyr
   1               5                  10                  15    
 Val Val Leu Gly Val Ser Ala Leu Gly Ile Met Met Phe Gly Ile Val
              20                  25                  30        
 Ser Phe Gly Ile Ile Ile Pro Thr Gln Trp Lys Glu Glu Gln Met Ser
          35                  40                  45            
 Ser Ile Gly Gly Ala Asn Leu Asp Leu Gln Ile Glu Gln Cys Ile Tyr
      50                  55                  60                
 Lys Met Lys Ser Asp Cys Thr Tyr Asp Thr Asn Val Lys Arg Asn Trp
  65                  70                  75                  80
 Glu Lys Leu Leu Pro Ala Ala Cys Ala Ile Val Ala Ile Glu Asn Ser
                  85                  90                  95    
 Gly Asp Val Ser Val Ile Pro Ser Arg Asn Pro Gly Gln Gln Ala Val
             100                 105                 110        
 Met Met Phe Val Ala Ser Thr Gly Ala Thr Pro Ile Thr Gly Cys Phe
         115                 120                 125            
 Thr Leu Gly Ile Phe Thr Thr Lys Ile Gln Glu Ala Thr Ser Ala Gly
     130                 135                 140                
 Asp Tyr
 145    



      <210> 1677
      <211> 378
      <212> PRT
      <213> Homo sapiens


      <400> 1677
 Met Thr Gln Ile Ser Asn Ile Lys Gln Pro Phe Ala Met Gln His Arg
   1               5                  10                  15    
 Phe Phe Ile Ser Leu Leu His Trp Thr Leu Gln Ile Val Tyr Pro Ala
              20                  25                  30        
 Leu Phe Leu Gly Leu Cys Glu Arg Gly Arg Asn Gly Arg Cys Asp Gln
          35                  40                  45            
 Val Pro Glu Gly Ser Val Leu Ser Leu Leu Val Trp Val Val Pro Gly
      50                  55                  60                
 Leu Ala Phe Pro Glu Val Ala Pro Gly Thr Cys Gly Thr Ser Tyr Val
  65                  70                  75                  80
 Pro Asp Ala Gly Leu His Gly Pro Glu Val Glu Ser Lys Leu Gly Leu
                  85                  90                  95    
 Asp Pro Gly Ser Met Thr Gly Thr Gln Pro Thr Arg Thr Pro Ala Gln
             100                 105                 110        
 Pro Ala Ala Ala Glu Pro Pro Ala Leu Thr Gly Pro Gly Arg Val His
         115                 120                 125            
 Gln Glu Gln Ala Val Leu Ala Cys Gly Phe Leu Gly Ile Tyr His Leu
     130                 135                 140                
 Gly Ala Ala Ser Ala Leu Cys Arg His Gly Lys Lys Leu Val Lys Asp
 145                 150                 155                 160
 Val Lys Ala Phe Ala Gly Ala Ser Ala Gly Ser Leu Val Ala Ser Val
                 165                 170                 175    
 Leu Leu Thr Ala Pro Glu Lys Ile Glu Glu Cys Asn Gln Phe Thr Tyr
             180                 185                 190        
 Lys Phe Ala Glu Glu Ile Arg Arg Gln Ser Phe Gly Ala Val Thr Pro
         195                 200                 205            
 Gly Tyr Asp Phe Met Ala Arg Leu Arg Ser Gly Met Glu Ser Ile Leu
     210                 215                 220                
 Pro Pro Ser Ala His Glu Leu Ala Gln Asn Arg Leu His Val Ser Ile
 225                 230                 235                 240
 Thr Asn Ala Lys Thr Arg Glu Asn His Leu Val Ser Thr Phe Ser Ser
                 245                 250                 255    
 Arg Glu Asp Leu Ile Lys Val Leu Leu Ala Ser Ser Phe Val Pro Ile
             260                 265                 270        
 Tyr Ala Gly Leu Lys Leu Val Glu Tyr Lys Gly Gln Lys Trp Val Asp
         275                 280                 285            
 Gly Gly Leu Thr Asn Ala Leu Pro Ile Leu Pro Val Gly Arg Thr Val
     290                 295                 300                
 Thr Ile Ser Pro Phe Ser Gly Arg Leu Asp Ile Ser Pro Gln Asp Lys
 305                 310                 315                 320
 Gly Gln Leu Asp Leu Tyr Val Asn Ile Ala Lys Gln Asp Ile Met Leu
                 325                 330                 335    
 Ser Leu Ala Asn Leu Val Arg Leu Asn Gln Ala Leu Phe Pro Pro Ser
             340                 345                 350        
 Lys Arg Lys Met Glu Ser Leu Tyr Gln Cys Gly Phe Asp Asp Thr Val
         355                 360                 365            
 Lys Phe Leu Leu Lys Glu Asn Trp Phe Glu
     370                 375            



      <210> 1678
      <211> 166
      <212> PRT
      <213> Homo sapiens


      <400> 1678
 Met Ser Asn Gln Val Leu Cys Cys Val Val Leu Cys Leu Leu Gly Ala
   1               5                  10                  15    
 Asn Thr Val Asp Gly Gly Ile Thr Gln Ser Pro Lys Tyr Leu Phe Arg
              20                  25                  30        
 Lys Glu Gly Gln Asn Val Thr Leu Ser Cys Glu Gln Asn Leu Asn His
          35                  40                  45            
 Asp Ala Met Tyr Trp Tyr Arg Gln Asp Pro Gly Gln Gly Leu Arg Leu
      50                  55                  60                
 Ile Tyr Tyr Ser Gln Ile Val Asn Asp Phe Gln Lys Gly Asp Ile Ala
  65                  70                  75                  80
 Glu Gly Leu Arg Leu Val Glu Ala Val Val Gly Gly Ile Val Gly Lys
                  85                  90                  95    
 Ile Ala Trp Ile Gly Met Asp Leu Glu Lys Lys Gln Ser Thr Leu Glu
             100                 105                 110        
 Glu Ile Ser Arg Thr Ala Asp Asp Val Ile Leu Ala Ser Val Ser His
         115                 120                 125            
 Val Asp Phe Cys Phe Ala Gly Glu Cys Ile Arg Pro Glu Pro Val Leu
     130                 135                 140                
 Ser Lys Ala Arg Arg Ile Leu Cys Ser Lys Leu Ala Leu Ala Ala Tyr
 145                 150                 155                 160
 Leu Pro Gln His Glu Ser
                 165    



      <210> 1679
      <211> 892
      <212> PRT
      <213> Homo sapiens


      <400> 1679
 Met Ala Asn His Cys Ile Phe Leu Asn Ser Ile Ser Ala Leu Val Leu
   1               5                  10                  15    
 Leu Leu Tyr Thr Lys His Ser Ala Gly Ile Cys Asn Gly Leu Gln Leu
              20                  25                  30        
 Leu Pro Leu Val Val Glu Gly Glu Pro Val Cys Glu Asp His Thr Val
          35                  40                  45            
 Arg Lys Gly Gly Gly Gly Gly Asp Arg Gln Ile Val Asp Ile Val Asn
      50                  55                  60                
 Ser Gln Leu Arg Ala Gly Tyr Asp Ile Leu Ile Met Ile Thr Phe Ile
  65                  70                  75                  80
 Cys Ile Thr His Tyr Asn Leu Met Leu Arg Lys Pro Lys Phe Pro Asp
                  85                  90                  95    
 Arg Cys Tyr Asp Thr Pro Arg Ile Lys Arg Ala Tyr Ala Arg Ser Ala
             100                 105                 110        
 Leu Gln Thr Ala Arg Gln Thr Ala Thr Lys Lys Leu Pro Gln Lys Gln
         115                 120                 125            
 Tyr Leu Asn Glu Ala Gly Ala Glu Glu Leu Ala Asp Asn Gly His Arg
     130                 135                 140                
 Ser Met Leu Gly His Val Asp Gly Ala Gly Ser Arg Tyr Pro Trp Gln
 145                 150                 155                 160
 Thr Asp Ala Gly Thr Glu Asn Gln Ile Leu His Val Leu Lys Trp Glu
                 165                 170                 175    
 Leu Asn Asp Glu Asn Thr Trp Thr His Gly Gly Asn Asn Thr His Cys
             180                 185                 190        
 Gly Leu Ser Glu Gly Asn Cys Asp Thr Met Val Phe Val Tyr Leu Asn
         195                 200                 205            
 Ile Glu Lys Cys Leu Asn Glu Ile Leu Glu Ser Ala Asp Ala Pro Leu
     210                 215                 220                
 Glu Val Thr Glu Gly Phe Ile Gln Ser Ile Ser Leu Ser Val Pro Trp
 225                 230                 235                 240
 Gly Ser Leu Leu Gln Asp Asn Cys Ala Leu Glu Val Arg Gly Leu Glu
                 245                 250                 255    
 Met Val Phe Arg Pro Arg Pro Arg Pro Ala Thr Gly Ser Glu Pro Met
             260                 265                 270        
 Tyr Trp Ser Ser Phe Met Thr Ser Ser Met Gln Leu Ala Lys Glu Cys
         275                 280                 285            
 Leu Ser Gln Lys Leu Thr Asp Glu Gln Gly Glu Gly Ser Gln Pro Phe
     290                 295                 300                
 Glu Gly Leu Glu Lys Phe Ala Glu Thr Ile Glu Thr Val Gln Ile Gly
 305                 310                 315                 320
 Arg Leu Ile Gly Arg Leu Glu Leu Ser Leu Thr Leu Lys Gln Asn Glu
                 325                 330                 335    
 Val Leu Pro Gly Ala Lys Lys Leu Ala Thr Val Glu Met Met Ala Ser
             340                 345                 350        
 His Met Tyr Thr Ser Tyr Asn Lys His Ile Ser Leu His Lys Ala Phe
         355                 360                 365            
 Thr Glu Val Phe Leu Asp Asp Ser His Ser Pro Ala Asn Cys Arg Ile
     370                 375                 380                
 Ser Val Gln Val Ala Thr Pro Ala Leu Asn Leu Ser Val Arg Phe Pro
 385                 390                 395                 400
 Ile Pro Asp Leu Arg Ser Asp Gln Glu Arg Gly Pro Trp Phe Lys Lys
                 405                 410                 415    
 Ser Leu Gln Lys Glu Ile Leu Tyr Leu Ala Phe Thr Asp Leu Glu Phe
             420                 425                 430        
 Lys Thr Glu Phe Ile Gly Gly Ser Thr Pro Glu Gln Ile Lys Leu Glu
         435                 440                 445            
 Leu Thr Phe Arg Glu Leu Ile Gly Ser Phe Gln Glu Glu Lys Gly Asp
     450                 455                 460                
 Pro Ser Ile Lys Phe Phe His Val Ser Ser Gly Val Asp Gly Asp Thr
 465                 470                 475                 480
 Thr Ser Ser Asp Asp Phe Asp Trp Pro Arg Ile Val Leu Lys Ile Asn
                 485                 490                 495    
 Pro Pro Ala Met His Ser Ile Leu Glu Arg Ile Ala Ala Glu Glu Glu
             500                 505                 510        
 Glu Glu Asn Asp Gly His Tyr Gln Glu Glu Glu Glu Gly Gly Ala His
         515                 520                 525            
 Ser Leu Lys Asp Met Val Met Pro Gly Asp Pro Val Glu Met Thr Glu
     530                 535                 540                
 Phe Gln Asp Lys Ala Ile Ser Asn Ser His Tyr Val Leu Glu Leu Thr
 545                 550                 555                 560
 Leu Pro Asn Ile Tyr Val Thr Leu Pro Asn Lys Ser Phe Tyr Glu Lys
                 565                 570                 575    
 Leu Tyr Asn Arg Ile Phe Asn Asp Leu Leu Leu Trp Glu Pro Thr Ala
             580                 585                 590        
 Pro Ser Pro Val Glu Thr Phe Glu Asn Ile Ser Tyr Gly Ile Gly Leu
         595                 600                 605            
 Ser Val Ala Ser Gln Leu Ile Asn Thr Phe Asn Lys Asp Ser Phe Ser
     610                 615                 620                
 Ala Phe Lys Ser Ala Val His Tyr Asp Glu Glu Ser Gly Ser Glu Glu
 625                 630                 635                 640
 Glu Thr Leu Gln Tyr Phe Ser Thr Val Asp Pro Asn Tyr Arg Ser Arg
                 645                 650                 655    
 Arg Lys Lys Lys Leu Asp Ser Gln Asn Lys Asn Ser Gln Ser Phe Leu
             660                 665                 670        
 Ser Val Leu Leu Asn Ile Asn His Gly Leu Ile Ala Val Phe Thr Asp
         675                 680                 685            
 Val Lys Glu Phe Leu Ile Ala Val Gly Leu Lys Gly Ala Thr Leu Gln
     690                 695                 700                
 His Arg Met Leu Pro Ser Gly Leu Ser Trp His Glu Gln Thr Glu Pro
 705                 710                 715                 720
 Arg Phe Glu Leu His Cys Ser Ser Asp Val Val His Ile Arg Thr Cys
                 725                 730                 735    
 Ser Asp Ser Cys Ala Ala Leu Met Asn Leu Ile Gln Tyr Ile Ala Ser
             740                 745                 750        
 Tyr Gly Asp Leu Gln Thr Pro Asn Lys Ala Asp Met Lys Pro Gly Ala
         755                 760                 765            
 Phe Gln Arg Arg Ser Lys Val Asp Ser Ser Gly Arg Ser Ser Ser Arg
     770                 775                 780                
 Gly Pro Val Leu Pro Glu Ala Asp Gln Gln Met Leu Arg Asp Leu Met
 785                 790                 795                 800
 Ser Asp Ala Met Glu Glu Ile Asp Met Gln Gln Gly Thr Ser Ser Val
                 805                 810                 815    
 Lys Pro Gln Ala Asn Gly Val Leu Asp Glu Lys Ser Gln Ile Gln Glu
             820                 825                 830        
 Pro Cys Cys Ser Asp Leu Phe Leu Phe Pro Asp Glu Ser Gly Asn Val
         835                 840                 845            
 Ser Gln Glu Ser Gly Pro Thr Tyr Ala Ser Phe Ser His His Phe Ile
     850                 855                 860                
 Ser Asp Ala Met Thr Gly Val Pro Thr Glu Asn Asp Asp Phe Cys Ile
 865                 870                 875                 880
 Leu Phe Ala Pro Lys Ala Ala Met Gln Val Ile Asn
                 885                 890        



      <210> 1680
      <211> 574
      <212> PRT
      <213> Homo sapiens


      <400> 1680
 Met Val Ala Pro Gly Leu Val Leu Gly Leu Val Leu Pro Leu Ile Leu
   1               5                  10                  15    
 Trp Ala Asp Arg Ser Ala Val Val Ile Arg Ala Lys Lys Tyr Asn Pro
              20                  25                  30        
 Leu Thr Ser Ser Asp Tyr Leu Arg Leu Ser Phe Asp Phe Trp Tyr Arg
          35                  40                  45            
 Leu Gln Ile Leu Val Val Gly Lys Cys Ile Gly Phe Arg Phe Ala Ser
      50                  55                  60                
 Tyr Ile Asn Asn Asp Met Val Leu Gln Lys Glu Pro Ala Gly Ala Val
  65                  70                  75                  80
 Ile Trp Gly Phe Gly Thr Pro Gly Ala Thr Val Thr Val Thr Leu Arg
                  85                  90                  95    
 Gln Gly Gln Glu Thr Ile Met Lys Lys Val Thr Ser Val Lys Ala His
             100                 105                 110        
 Ser Asp Thr Trp Met Val Val Leu Asp Pro Met Lys Pro Gly Gly Pro
         115                 120                 125            
 Phe Glu Val Met Ala Gln Gln Thr Leu Glu Lys Ile Asn Phe Thr Leu
     130                 135                 140                
 Arg Val His Asp Val Leu Phe Gly Asp Val Trp Leu Cys Ser Gly Gln
 145                 150                 155                 160
 Ser Asn Met Gln Met Thr Val Leu Gln Ile Phe Asn Ala Thr Arg Glu
                 165                 170                 175    
 Leu Ser Asn Thr Ala Ala Tyr Gln Ser Val Arg Ile Leu Ser Val Ser
             180                 185                 190        
 Pro Ile Gln Ala Glu Gln Glu Leu Glu Asp Leu Val Ala Val Asp Leu
         195                 200                 205            
 Gln Trp Ser Lys Pro Thr Ser Glu Val Val Pro Val Phe Pro Leu Asp
     210                 215                 220                
 Phe Phe Phe Phe Ser Cys Ala Cys Phe Pro Trp Cys Ser Asp Ala Pro
 225                 230                 235                 240
 Thr Phe Ile Ser Ser Asn Ser Leu Asn Lys Tyr Leu Ser Val Tyr Tyr
                 245                 250                 255    
 Val Leu Asp Thr Val Leu Ser Ala Gly Asp Ile Val Val Pro Asn Leu
             260                 265                 270        
 Asn His Ile Tyr Lys Val Pro Phe Ala Met Gln Gly Asn Thr Ala Thr
         275                 280                 285            
 Gly Ser Arg Asp Glu Cys Val Asp Val Phe Gly Val Cys Tyr Phe Ala
     290                 295                 300                
 Tyr Thr Pro His Ser His Ser Gln Ala Phe Ser Lys Asn Leu Gly His
 305                 310                 315                 320
 Gly Tyr Phe Lys Tyr Met Ser Ala Val Cys Trp Leu Phe Gly Arg His
                 325                 330                 335    
 Leu Tyr Asp Thr Leu Gln Tyr Pro Ile Gly Leu Ile Ala Ser Ser Trp
             340                 345                 350        
 Gly Gly Thr Pro Ile Glu Ala Trp Ser Ser Gly Arg Ser Leu Lys Ala
         355                 360                 365            
 Cys Gly Val Pro Lys Gln Gly Tyr Asp Val Gly Lys Gly Phe Ser Val
     370                 375                 380                
 His Val Asn Thr Cys Ser Cys Val Glu Arg Lys Arg Phe Met Gly Ile
 385                 390                 395                 400
 Gly Thr Leu Ser Cys Gly Val Val Thr Val Ile Phe Ile Met Thr Leu
                 405                 410                 415    
 Ala Gly Ala His Gly Ser Thr Leu Ser Ser Gly Ile Phe Ser Ile Tyr
             420                 425                 430        
 Gln Ser Asp Ser Leu Lys Cys Lys Ser Gly Arg Lys Ala Pro Val Gly
         435                 440                 445            
 Pro His Leu Ser Lys Lys Ser Ser Asp Asp Gly Phe Pro Gln Ile Arg
     450                 455                 460                
 Trp His Gln Thr Ala Asp Phe Gly Tyr Val Pro Asn Pro Lys Met Pro
 465                 470                 475                 480
 Asn Thr Phe Met Ala Val Ala Met Asp Leu Cys Asp Arg Asp Ser Pro
                 485                 490                 495    
 Phe Gly Ser Ile His Pro Arg Asp Lys Gln Thr Val Ala Tyr Arg Leu
             500                 505                 510        
 His Leu Gly Ala Arg Ala Leu Ala Tyr Gly Glu Lys Asn Leu Thr Phe
         515                 520                 525            
 Glu Gly Pro Leu Pro Glu Lys Ile Glu Leu Leu Ala His Lys Gly Leu
     530                 535                 540                
 Leu Asn Leu Thr Tyr Tyr Gln Gln Ile Gln Val Gln Lys Lys Asp Asn
 545                 550                 555                 560
 Lys Ile Phe Glu Thr Ala Leu Gly Asn Leu Leu Leu Gly Asn
                 565                 570                



      <210> 1681
      <211> 217
      <212> PRT
      <213> Homo sapiens


      <400> 1681
 Met Pro Phe Thr Gln Gly Leu Gln Gln Cys Leu Leu Leu Ala Thr Pro
   1               5                  10                  15    
 Ala Ala Gly Ser Thr Leu Arg Ala Thr Ser Leu Pro Gly His Ser Ala
              20                  25                  30        
 Arg Gly His Asp Gly Ala Gln Thr Ile Ser Asn Val Gly Leu Leu Trp
          35                  40                  45            
 His Gln Ser Gln Ser Arg His Thr Arg Leu Met Leu Glu Pro Asn Pro
      50                  55                  60                
 Met Leu Lys His Leu Thr Gly Trp Leu Leu Ser His Ser Val Pro Arg
  65                  70                  75                  80
 Glu Lys Val Asp Lys Glu Leu Thr Lys Val Leu Leu Glu Leu Tyr Gly
                  85                  90                  95    
 Lys Glu Ala Lys Tyr Asn His Ser Tyr Leu Val Phe Pro Lys Asp Met
             100                 105                 110        
 Glu Glu Ser Pro Met Leu Tyr Leu Phe Ile Glu Glu Met Glu Arg Val
         115                 120                 125            
 His Leu Thr Lys Ile Trp Leu Gln Gln Cys Arg Asp Leu Ala Val His
     130                 135                 140                
 Thr Ala Ala Lys Ser Val Lys Met Lys Lys Ser Asn Leu Lys Asn Phe
 145                 150                 155                 160
 Met Ala Ala Glu Asp Glu Gly Asn Glu Asp Lys His Ile Lys Lys Leu
                 165                 170                 175    
 Leu Asp Thr Thr Asp Asn Lys Ser Ser Ala Leu Thr Ser Pro Asn Phe
             180                 185                 190        
 Gln Val Glu Ser Ser Pro Lys Pro Thr Phe Pro Glu Ala Gly Pro Glu
         195                 200                 205            
 Ile Ser Phe Asn Phe Ile Cys Gln Asp
     210                 215        



      <210> 1682
      <211> 387
      <212> PRT
      <213> Homo sapiens


      <400> 1682
 Met Leu Phe His Ile Phe Leu Ser Met Phe Ala Ile Cys Val Asn Val
   1               5                  10                  15    
 Lys Met Ser Trp Gln Ser Val Thr Phe Glu Arg Gln Pro Ala Ser Phe
              20                  25                  30        
 Ile Arg Ile Val Gly Thr His Asn Thr Ala Asn Glu Leu Leu Ser Val
          35                  40                  45            
 Cys Glu Pro Arg Asp Phe Val Leu Ala Ser Lys Thr Ile Asp Gly Phe
      50                  55                  60                
 Gly Leu Trp His Gly Lys Val Cys Leu Cys Val Tyr Asn Lys Gly Lys
  65                  70                  75                  80
 Ser Ala Leu Gly Gly Lys Ser Glu Asp Ala Val Thr Ala Ala Leu Phe
                  85                  90                  95    
 Ile Leu Asn Pro Thr Gly Tyr His Glu Arg Pro Ser Thr Glu Asp Gly
             100                 105                 110        
 Pro Trp Ala Arg Ala Leu Val Trp Asp Ser Lys Gly Asn Glu Leu Ser
         115                 120                 125            
 Gly Ile Thr Cys Asp Ser Leu Lys Pro Asp Glu Gly Ile Thr Glu Asp
     130                 135                 140                
 Gly Ile Lys Ala Val Thr Ala Met Pro Leu Glu Asn Gly Arg Ala Leu
 145                 150                 155                 160
 Met Val Arg Ala Met Ala Tyr Pro Cys Leu Arg Gly Ala Glu Leu Gly
                 165                 170                 175    
 Ala Val Pro Cys Leu His Ser Ala Gly Thr Val Leu Ala Gln Ser Ser
             180                 185                 190        
 Trp Cys Phe Gln Ala Asp Leu Leu Ser Asp Lys Glu Lys Tyr Gly Asp
         195                 200                 205            
 Asp Gly Val Ala Leu Thr Val Asp Val Ile Glu Phe Pro Glu Glu Arg
     210                 215                 220                
 Glu Gly Gln Gly Leu Asn Gly Met Gln Asp Asn Trp Asn Ala Pro Ile
 225                 230                 235                 240
 Ser Leu Ala Asp Thr Asp Pro Val Ile Pro Gly Ala Gly Arg Asp Leu
                 245                 250                 255    
 Glu Ala Leu Val Ile Cys Arg Val Asn Gly Val Trp Cys Ala Ser Asp
             260                 265                 270        
 Cys Ala Ala Leu Ser Ser Val Phe Leu Arg Ala Asn Val Cys Ile Glu
         275                 280                 285            
 Gln Val Thr Arg Asn Cys Val Ser His Leu Tyr Thr Asp Ile His Ser
     290                 295                 300                
 Ser Leu Ile His Ser Asn Tyr Asn Met Glu Ala Thr Pro Val Pro Thr
 305                 310                 315                 320
 Asp Lys Gly Val Gly Lys His Val Cys Phe Ile Ile Arg Cys Ser Ser
                 325                 330                 335    
 Ile His Leu Lys Lys Asp Thr Asp Ile Ser Thr Met Trp Met Ser Pro
             340                 345                 350        
 Glu Asp Ile Val Leu Gly Glu Ile Gly Gln Thr Gln Thr Asp Glu Tyr
         355                 360                 365            
 Cys Met Ile Pro Leu Pro Val Leu Glu Met Asp Gly Gly Asn Gly Cys
     370                 375                 380                
 Thr Thr Leu
 385        



      <210> 1683
      <211> 192
      <212> PRT
      <213> Homo sapiens


      <400> 1683
 Met Ala Ser Leu Phe Arg Ser Tyr Leu Pro Ala Ile Trp Leu Leu Leu
   1               5                  10                  15    
 Ser Gln Leu Leu Arg Glu Ser Leu Ala Ala Glu Leu Arg Gly Cys Gly
              20                  25                  30        
 Pro Arg Phe Gly Lys His Leu Leu Ser Tyr Cys Pro Met Pro Glu Lys
          35                  40                  45            
 Thr Phe Thr Thr Thr Pro Gly Gly Trp Leu Leu Glu Ser Gly Arg Pro
      50                  55                  60                
 Lys Val Asn Ser Asp Ser Thr Val Ala Ser Ala Tyr Lys Phe Val Val
  65                  70                  75                  80
 Phe His Cys Asn Val Leu Leu Leu Lys Gly Ser His Gln Lys Ser His
                  85                  90                  95    
 Gly Lys Leu Gly Val Glu Glu Lys Leu Gln Glu Lys Gln Lys Asn Ser
             100                 105                 110        
 Leu Thr Leu Glu Ala Leu Gly Ala Phe Pro Thr Trp Gln Pro Glu Ile
         115                 120                 125            
 Gln Gly Gly Glu Asn Arg Glu Ser Ser Glu Lys Val Thr Ile Leu Lys
     130                 135                 140                
 His Gln Gln Glu Cys Val Glu Arg Asp Glu Met Lys Arg Lys Lys Val
 145                 150                 155                 160
 Ala Trp Met Thr Arg Gly Glu Ile Glu Gly Asp Gln Arg Gln Gly Asn
                 165                 170                 175    
 Phe Thr Val Gln Thr Ile Ile Ala Asp Leu Ile Ser Val Phe Asn Ile
             180                 185                 190        





      <210> 1684
      <211> 308
      <212> PRT
      <213> Homo sapiens


      <400> 1684
 Met Ala Cys Thr Val Val Leu Ile Thr Gly Cys Ser Ser Gly Ile Gly
   1               5                  10                  15    
 Leu His Leu Ala Ile His Leu Ala Leu Asp Pro Ser Gln Ser Phe Lys
              20                  25                  30        
 Val Tyr Ala Thr Leu Arg Asp Leu Lys Thr Gln Gly Arg Leu Trp Glu
          35                  40                  45            
 Ala Ala Arg Ala Leu Ala Cys Pro Gln Gly Ser Leu Glu Arg Leu Gln
      50                  55                  60                
 Leu Asp Val Arg Asn Ser Ser Ser Leu Ala Ala Ala Arg Glu Arg Val
  65                  70                  75                  80
 Thr Glu Gly Arg Val Asp Val Leu Val Cys Asp Thr Gly Leu Gly Leu
                  85                  90                  95    
 Leu Gly Pro Leu Gly Glu Asp Ala Val Ala Ser Val Leu Asp Val Asn
             100                 105                 110        
 Val Val Gly Thr Val Arg Val Leu Gln Asp Phe Leu Pro Asp Met Lys
         115                 120                 125            
 Arg Pro Gly Ser Gly Arg Val Leu Val Thr Gly Ser Met Gly Gly Leu
     130                 135                 140                
 Met Gly Leu Pro Phe Asn Asp Val Tyr Cys Ala Ser Lys Phe Ala Leu
 145                 150                 155                 160
 Glu Gly Leu Cys Glu Ser Leu Ala Val Leu Leu Leu Pro Phe Gly Val
                 165                 170                 175    
 His Lys Glu Ile Tyr Arg Glu Glu Ala Gln His Pro Glu Glu Val Val
             180                 185                 190        
 Lys Val Phe Leu Thr Ala Met Arg Ala Pro Lys Pro Thr Leu Arg Tyr
         195                 200                 205            
 Phe Thr Thr Arg Arg Phe Leu His Gln Leu Leu Met Arg Leu Asp Asp
     210                 215                 220                
 Pro Phe Gly Phe Asp Tyr Ala Ala Ala Met His Arg Asp Val Phe Ala
 225                 230                 235                 240
 Asp Asp Pro Ala Glu Ala Glu Ala Gly Ala Gly Ala Gly Ala Glu Ala
                 245                 250                 255    
 Gly Gly Gly Ala Gly Gly Met Gly Asp Pro Glu Leu Ser Asp Pro Leu
             260                 265                 270        
 Ala Ala Pro Gln Glu Arg Leu Arg Gln Pro Leu Ser Pro Ala Pro Ser
         275                 280                 285            
 Phe Val Ser Trp Ala Cys Ala Val Pro Gly Asp Gly Thr Ala Val Thr
     290                 295                 300                
 Ala Val Asp Gly
 305            



      <210> 1685
      <211> 339
      <212> PRT
      <213> Homo sapiens


      <400> 1685
 Met Gly Val Pro Arg Val Ile Leu Leu Cys Leu Phe Gly Ala Ala Leu
   1               5                  10                  15    
 Cys Leu Thr Gly Ser Gln Ala Leu Gln Cys Tyr Ser Phe Glu His Thr
              20                  25                  30        
 Tyr Phe Gly Pro Phe Asp Leu Arg Ala Met Lys Leu Pro Ser Ile Ser
          35                  40                  45            
 Cys Pro His Glu Cys Phe Glu Ala Ile Leu Ser Leu Asp Thr Gly Tyr
      50                  55                  60                
 Arg Ala Pro Val Thr Leu Val Arg Lys Gly Cys Trp Thr Gly Pro Pro
  65                  70                  75                  80
 Ala Gly Gln Thr Gln Ser Asn Pro Asp Ala Leu Pro Pro Asp Tyr Ser
                  85                  90                  95    
 Val Val Arg Gly Cys Thr Thr Asp Lys Cys Asn Ala His Leu Met Thr
             100                 105                 110        
 His Asp Ala Leu Pro Asn Leu Ser Gln Ala Pro Asp Pro Pro Thr Leu
         115                 120                 125            
 Ser Gly Ala Glu Cys Tyr Ala Cys Ile Gly Val His Gln Asp Asp Cys
     130                 135                 140                
 Ala Ile Gly Arg Ser Arg Arg Val Gln Cys His Gln Asp Gln Thr Ala
 145                 150                 155                 160
 Cys Phe Gln Gly Asn Gly Arg Met Thr Val Gly Asn Phe Ser Val Pro
                 165                 170                 175    
 Val Tyr Ile Arg Thr Cys His Arg Pro Ser Cys Thr Thr Glu Gly Thr
             180                 185                 190        
 Thr Ser Pro Trp Thr Ala Ile Asp Leu Gln Gly Ser Cys Cys Glu Gly
         195                 200                 205            
 Tyr Leu Cys Asn Arg Lys Ser Met Thr Gln Pro Phe Thr Ser Ala Ser
     210                 215                 220                
 Ala Thr Thr Pro Pro Arg Ala Leu Gln Val Leu Ala Leu Leu Leu Pro
 225                 230                 235                 240
 Val Leu Leu Leu Lys Asn Thr Gln Gly Lys Val Gln Arg Gly Glu Ile
                 245                 250                 255    
 Leu Gln Ala Ile Lys Ile Arg Glu Asp Phe Leu Glu Glu Phe Thr Leu
             260                 265                 270        
 Glu Gln Asn Pro Lys Gly Ser Ile Val Ala Gly Lys Lys Lys Gln Glu
         275                 280                 285            
 Glu Ala His Ser Arg Pro Cys Asp Lys Gly Phe Arg Cys Leu Tyr Ile
     290                 295                 300                
 Leu Thr Tyr Lys Gly Lys Leu Asp Val Phe Ile His Pro Ser His Leu
 305                 310                 315                 320
 Leu Ser Thr Tyr Tyr Val Gln Gly Thr Val Pro Val Ala Gly His Ala
                 325                 330                 335    
 Ala Gly Asn
            



      <210> 1686
      <211> 929
      <212> PRT
      <213> Homo sapiens


      <400> 1686
 Met Gly Ile Ile Leu Leu Ala Leu Leu Leu Leu Val Phe Ala Gly Ala
   1               5                  10                  15    
 Arg Lys Ser Lys Met Ala Ser Ser Leu Thr Phe Leu Val Pro Gln Val
              20                  25                  30        
 Ile Ile Tyr Asn Tyr Ser Leu Thr Gln Ser Arg Glu Glu Ala Val Gln
          35                  40                  45            
 Asn Gly Thr Leu Tyr Pro Gly Pro Leu Leu Ala Gly Glu Arg Ala Pro
      50                  55                  60                
 His Leu Ala Arg Thr Ser Ala Leu Pro Ala Arg Arg Gly Val Arg Arg
  65                  70                  75                  80
 Gly Arg Gly Ala Glu Ala Gln Pro Gly Val Arg Glu Gly Ala Val Arg
                  85                  90                  95    
 Cys Ala Gly Gly Ser Val Tyr Asp Glu Gln Arg Gly Leu Pro Trp Val
             100                 105                 110        
 Gly Gly Cys Ser Gly Ala Cys Gly Arg Cys Thr Ser Ser Cys Gly Arg
         115                 120                 125            
 Val Ser Pro Ala Arg Ser His Arg Thr Phe Arg Ser Arg Ala Gln Ser
     130                 135                 140                
 Gly Lys Glu Arg Glu Glu Val Asn Leu Gly Asn Asp Leu Leu Lys Arg
 145                 150                 155                 160
 Thr Cys Asp Leu Gln Val Arg Asp Leu Ala Ser Trp Lys Arg Phe His
                 165                 170                 175    
 Arg Gly Ser Gln Asn Thr Asp Thr Leu Asn Val Leu Leu Ile Ala Ser
             180                 185                 190        
 Leu Arg Tyr Arg Trp Val Thr Pro Leu Ala Lys Leu Thr Gly Ser Leu
         195                 200                 205            
 Arg Ala Arg Glu Pro Val Asp Val Val His Lys Asp Glu Pro Pro Gly
     210                 215                 220                
 Ala Asp Ser Leu Val Thr Lys Val Asn Asn Asp Met Ile Val Thr Asp
 225                 230                 235                 240
 Asn Asn Gly Ala Val Lys Phe Pro Gln Leu Cys Lys Phe Cys Asp Val
                 245                 250                 255    
 Arg Phe Ser Thr Cys Asp Asn Gln Lys Ser Cys Met Ser Asn Cys Ser
             260                 265                 270        
 Ile Thr Ser Ile Cys Glu Lys Pro Gln Glu Val Cys Val Ala Val Trp
         275                 280                 285            
 Arg Lys Asn Asp Glu Asn Ile Thr Leu Glu Thr Val Cys His Asp Pro
     290                 295                 300                
 Lys Leu Pro Tyr His Asp Phe Ile Leu Glu Asp Ala Ala Ser Pro Lys
 305                 310                 315                 320
 Cys Ile Met Lys Glu Lys Lys Lys Pro Gly Glu Thr Phe Phe Met Cys
                 325                 330                 335    
 Ser Cys Ser Ser Asp Glu Cys Asn Asp Asn Ile Ile Phe Ser Glu Asp
             340                 345                 350        
 Ser Leu His Phe Tyr Asp Glu Val Lys Pro Val Asn Trp Leu Leu Gln
         355                 360                 365            
 Thr Ser His Phe Asn Asp Lys Lys Val Gly Leu Gln Arg Gly Ala Gly
     370                 375                 380                
 Ile Phe Gln Asp Leu Ile Val Cys Ser Ser Leu Phe Val Arg Arg Arg
 385                 390                 395                 400
 Ile Ile Glu Glu Pro Asp Asn Leu Val Ser Tyr Arg Arg Asn Thr Leu
                 405                 410                 415    
 Thr Leu Pro His Ser Arg Gly Gly Gly Arg Cys Lys Ile Arg His Ile
             420                 425                 430        
 Gly Ser Asn Asn Arg Leu Gln Arg Ser Thr Cys Gln Asn Thr Gly Trp
         435                 440                 445            
 Glu Ser Ala His Val Met Lys Thr Pro Gly Phe Arg Glu Tyr Asn Thr
     450                 455                 460                
 Ser Asn Pro Asp Leu Leu Leu Val Ile Phe Gln Val Thr Gly Ile Ser
 465                 470                 475                 480
 Leu Leu Pro Pro Leu Gly Val Ala Ile Ser Val Ile Ile Ile Phe Tyr
                 485                 490                 495    
 Cys Tyr Arg Val Asn Arg Gln Gln Lys Leu Ser Ser Thr Trp Glu Thr
             500                 505                 510        
 Gly Lys Thr Arg Lys Leu Met Glu Phe Ser Glu His Cys Ala Ile Ile
         515                 520                 525            
 Leu Glu Asp Asp Arg Ser Asp Ile Ser Ser Thr Cys Ala Asn Asn Ile
     530                 535                 540                
 Asn His Asn Thr Glu Leu Leu Pro Ile Glu Leu Asp Thr Leu Val Gly
 545                 550                 555                 560
 Lys Gly Arg Phe Ala Glu Val Tyr Lys Ala Lys Leu Lys Gln Asn Thr
                 565                 570                 575    
 Ser Glu Gln Phe Glu Thr Val Ala Val Lys Ile Phe Pro Tyr Glu Glu
             580                 585                 590        
 Tyr Ala Ser Trp Lys Thr Glu Lys Asp Ile Phe Ser Asp Ile Asn Leu
         595                 600                 605            
 Lys His Glu Asn Ile Leu Gln Phe Leu Thr Ala Glu Glu Arg Lys Thr
     610                 615                 620                
 Glu Leu Gly Lys Gln Tyr Trp Leu Ile Thr Ala Phe His Ala Lys Gly
 625                 630                 635                 640
 Asn Leu Gln Glu Tyr Leu Thr Arg His Val Ile Ser Trp Glu Asp Leu
                 645                 650                 655    
 Arg Lys Leu Gly Ser Ser Leu Ala Arg Gly Ile Ala His Leu His Ser
             660                 665                 670        
 Asp His Thr Pro Cys Gly Arg Pro Lys Met Pro Ile Val His Arg Asp
         675                 680                 685            
 Leu Lys Ser Ser Asn Ile Leu Val Lys Asn Asp Leu Thr Cys Cys Leu
     690                 695                 700                
 Cys Asp Phe Gly Leu Ser Leu Arg Leu Asp Pro Thr Leu Ser Val Asp
 705                 710                 715                 720
 Asp Leu Ala Asn Ser Gly Gln Val Gly Thr Ala Arg Tyr Met Ala Pro
                 725                 730                 735    
 Glu Val Leu Glu Ser Arg Met Asn Leu Glu Asn Val Glu Ser Phe Lys
             740                 745                 750        
 Gln Thr Asp Val Tyr Ser Met Ala Leu Val Leu Trp Glu Met Thr Ser
         755                 760                 765            
 Arg Cys Asn Ala Val Gly Gly Ser Phe Phe Pro Glu His Thr Val Ile
     770                 775                 780                
 Ala Ser Gln Val Pro Ser Ala Met Ser Ser Leu Gln Leu Tyr Ala Glu
 785                 790                 795                 800
 Ser Phe Ser Leu Leu Glu Ala Val Thr Thr Ile Asp His Glu Thr Val
                 805                 810                 815    
 Asp Arg Met Gly Asn Lys His Leu Gly Cys Gln Glu Val Lys Asp Tyr
             820                 825                 830        
 Glu Pro Pro Phe Gly Ser Lys Val Arg Glu His Pro Cys Val Glu Ser
         835                 840                 845            
 Met Lys Asp Asn Val Leu Arg Asp Arg Gly Arg Pro Glu Ile Pro Ser
     850                 855                 860                
 Phe Trp Leu Asn His Gln Gly Ile Gln Met Val Cys Glu Thr Leu Thr
 865                 870                 875                 880
 Glu Cys Trp Asp His Asp Pro Glu Ala Arg Leu Thr Ala Gln Cys Val
                 885                 890                 895    
 Ala Glu Arg Phe Ser Glu Leu Glu His Leu Asp Arg Leu Ser Gly Arg
             900                 905                 910        
 Ser Cys Ser Glu Glu Lys Ile Pro Glu Asp Gly Ser Leu Asn Thr Thr
         915                 920                 925            
 Lys
    



      <210> 1687
      <211> 150
      <212> PRT
      <213> Homo sapiens


      <400> 1687
 Met Arg Thr Gly Leu Glu Leu Trp Gln Ser Leu Leu Thr Pro Leu Val
   1               5                  10                  15    
 Pro Gly Trp Cys Leu Leu His Val Thr Leu Asn Pro Asn Ser Arg Arg
              20                  25                  30        
 Leu His Val Leu Ala His Ser Arg Ala Lys Ala Ser Lys Asp Gly Lys
          35                  40                  45            
 Gly Gly Gln Ala Ala Arg Leu Gln Glu Glu Cys Asp Tyr Val Gln Met
      50                  55                  60                
 Ile Glu Val Gln His Lys Gln Cys Leu Glu Glu Ala Gln Leu Glu Asn
  65                  70                  75                  80
 Glu Thr Ile Gly Cys Ser Lys Met Trp Asp Asn Leu Thr Cys Trp Pro
                  85                  90                  95    
 Ala Thr Pro Arg Gly Gln Val Val Val Leu Ala Cys Pro Leu Ile Phe
             100                 105                 110        
 Lys Leu Phe Ser Ser Ile Gln Val Asn Glu Ala Leu Thr Ser Val Pro
         115                 120                 125            
 Gly Thr Glu Leu Asp Lys His Ser Gly Glu Arg Ile Lys Gln Pro Pro
     130                 135                 140                
 Gly Leu Leu Ser Gln Ser
 145                 150



      <210> 1688
      <211> 233
      <212> PRT
      <213> Homo sapiens


      <400> 1688
 Met Arg Leu Phe Ser Met His Phe His Leu Val Ala Leu Val Ser Leu
   1               5                  10                  15    
 Arg Thr Trp Glu Ser Leu Ala Glu Ser Cys His Ile Asp Phe Leu Thr
              20                  25                  30        
 Ala Val Ala Gln Arg Lys Val Gly Cys Val Pro Ser Gly Pro Arg Pro
          35                  40                  45            
 Leu Arg Asn His Cys Asp Asp Phe Asp Val Phe Ser Pro Asn Ser Met
      50                  55                  60                
 Gln Gly Thr Val Ser Arg Lys Gly His Leu Ala Gly Phe Leu Leu Phe
  65                  70                  75                  80
 Lys Asp Phe Cys Leu Asn Glu Ile Asn Glu Ala Val Pro Gln Val Lys
                  85                  90                  95    
 Phe Tyr Glu Glu Gln Arg Glu Gln Gln Leu Ile Ser Ala Val Phe Pro
             100                 105                 110        
 Phe His Tyr Thr Ile Trp Arg Ile Leu Arg Gly Asn Thr Phe Trp Arg
         115                 120                 125            
 Trp Ala Ser Ser Ser Phe Ser Val Val Pro Ser Ser Tyr Pro Ala Gly
     130                 135                 140                
 Leu Thr Arg Gly Val Thr Ile Phe Val Ala Leu Tyr Asp Tyr Glu Ala
 145                 150                 155                 160
 Arg Thr Thr Glu Asp Leu Ser Phe Lys Lys Gly Glu Lys Phe Gln Ile
                 165                 170                 175    
 Ile Asn Asn Thr Glu Gly Asp Trp Trp Glu Ala Arg Ser Ile Thr Thr
             180                 185                 190        
 Gly Lys Asn Gly Tyr Ile Leu Ser Ser Tyr Val Ala Pro Ala Asp Ser
         195                 200                 205            
 Ile Gln Ala Glu Glu Trp Tyr Phe Gly Lys Met Gly Arg Lys Asp Ala
     210                 215                 220                
 Glu Arg Leu Leu Leu Asn Pro Gly Asn
 225                 230            



      <210> 1689
      <211> 137
      <212> PRT
      <213> Homo sapiens


      <400> 1689
 Met Trp Lys Arg Leu Trp Thr Trp Val Ile Gly Arg Gly Trp Asn Ser
   1               5                  10                  15    
 Leu Glu Asn Ser Glu Glu Asp Lys Lys Ile Trp Glu Arg Leu Glu Leu
              20                  25                  30        
 Pro Arg Asp Leu Leu Asn Gly Phe Asp Gln Asn Ala Glu Ser Asp Met
          35                  40                  45            
 Glu Asn Glu Met Lys Ser Arg Pro Arg Ser Ser Trp Ile Val Leu Val
      50                  55                  60                
 Val Pro Lys Ser Asn Glu Lys Gly Lys Ile His Lys Lys Arg Arg Arg
  65                  70                  75                  80
 Gln Ile Gln Thr Glu Pro Tyr Glu Glu Ala Ile Met Lys Phe Cys Leu
                  85                  90                  95    
 Glu Leu Gly His Gln Val Cys Gln Ser Leu Gly Pro Ser Gly Gly Ser
             100                 105                 110        
 Cys Gly Leu Ser Val Leu Ile Leu Arg Ser Gly Ala Ala Asp Ser Asp
         115                 120                 125            
 Thr Val Val Ser Glu Ser Trp Arg Ser
     130                 135        



      <210> 1690
      <211> 457
      <212> PRT
      <213> Homo sapiens


      <400> 1690
 Met Lys Val Ala Phe Pro Ala Glu Ala Leu Gly Glu Asn Leu Leu Cys
   1               5                  10                  15    
 Leu Phe His Leu Leu Lys Ala Ala Tyr Val Pro Leu Leu Leu Ile Thr
              20                  25                  30        
 Pro His Pro Thr Pro Pro Tyr Cys Ile Phe Lys Ala Ser Asn Ile Val
          35                  40                  45            
 Ser Leu Asp Leu Leu Arg Leu Pro Gly Val Ser Gln His Phe Gly Arg
      50                  55                  60                
 Leu Arg Thr Val Glu Asp Leu Lys Asn Asn Glu Ser Gln Trp Lys Asp
  65                  70                  75                  80
 Ser Pro Leu Ala Thr Arg His Arg Glu Met Leu Lys Arg Cys Lys Thr
                  85                  90                  95    
 Gln Leu Lys Lys Leu Val Arg Cys Lys Ala Cys Ala Asp Ala Gly Leu
             100                 105                 110        
 Leu Asp Glu Ser Phe Leu Arg Arg Cys Leu Asn Phe Tyr Gly Leu Leu
         115                 120                 125            
 Ile Gln Leu Leu Leu Arg Ile Leu Asp Pro Ala Tyr Pro Asp Ile Thr
     130                 135                 140                
 Leu Pro Leu Asn Ser Asp Val Pro Lys Val Phe Ala Ala Leu Pro Glu
 145                 150                 155                 160
 Phe Tyr Val Glu Asp Val Ala Glu Phe Leu Phe Phe Ile Val Gln Tyr
                 165                 170                 175    
 Ser Pro Gln Ala Leu Tyr Glu Pro Cys Thr Gln Asp Ile Val Met Phe
             180                 185                 190        
 Leu Val Val Met Leu Cys Asn Gln Asn Tyr Ile Arg Asn Pro Tyr Leu
         195                 200                 205            
 Val Ala Lys Leu Val Glu Val Met Phe Met Thr Asn Pro Ala Val Gln
     210                 215                 220                
 Pro Arg Thr Gln Lys Phe Phe Glu Met Ile Glu Asn His Pro Leu Ser
 225                 230                 235                 240
 Thr Lys Leu Leu Val Pro Ser Leu Met Lys Phe Tyr Thr Asp Val Glu
                 245                 250                 255    
 His Thr Gly Ala Thr Ser Glu Phe Tyr Asp Lys Phe Thr Ile Arg Tyr
             260                 265                 270        
 His Ile Ser Thr Ile Phe Lys Ser Leu Trp Gln Asn Ile Ala His His
         275                 280                 285            
 Gly Thr Phe Met Glu Glu Phe Lys Leu Ile Leu Asp Gln Gly Thr Ala
     290                 295                 300                
 Gly Pro Pro Val Ser Leu Gln Asn Leu His Gln Ala Gln Thr Gly Ala
 305                 310                 315                 320
 Leu Ser Gln Arg Ala Leu Thr Gly Gln Leu Gln Leu Cys Gln Leu Cys
                 325                 330                 335    
 Ser Phe Pro Asn Lys Lys Arg Pro Leu Asn Arg Ser His Gly Arg Val
             340                 345                 350        
 Glu Gly Gly Lys Cys Ala Arg Gly Lys Arg Ala Asp Ser Ser Val Asp
         355                 360                 365            
 Gln Gln Gln Ala Arg Gln Ser Gln Leu Ala Gln Asp Glu Arg Val Ser
     370                 375                 380                
 Arg Ser Tyr Leu Ala Leu Ala Thr Glu Thr Val Asp Met Phe His Ile
 385                 390                 395                 400
 Leu Thr Lys Gln Val Gln Lys Pro Phe Leu Arg Pro Leu Met Ile His
                 405                 410                 415    
 Ser Thr Cys Lys Asp Ser Leu Lys Ile Asn Pro Thr Asn Ser Cys Ser
             420                 425                 430        
 Ser Thr Glu Met Gly Val Phe Gly Pro Phe His Leu Ser Gln Gln His
         435                 440                 445            
 Glu Leu Ser Tyr Tyr Pro Val Ile Ser
     450                 455        



      <210> 1691
      <211> 127
      <212> PRT
      <213> Homo sapiens


      <400> 1691
 Met Ala Leu Ala Ala Val Cys Leu Ala Leu Val Arg Pro Cys Lys Met
   1               5                  10                  15    
 Gly Leu Cys Gln His His His Ser Gly Glu Thr Lys Val Val Ser His
              20                  25                  30        
 Arg Gly Lys Thr Leu Gln Asp Ile Pro Glu Asp Phe Leu Glu Met Asp
          35                  40                  45            
 Leu Ala Lys Asn Glu His Arg Val His Val Gln Met Glu Pro Leu Lys
      50                  55                  60                
 Arg Val Phe Ala Ala Met Lys Gln Leu Asp Asn His Arg Thr Leu Lys
  65                  70                  75                  80
 Ala Leu Cys Arg Glu Pro Thr Gly Ser Ala Ser Glu Asp Gly Trp Ile
                  85                  90                  95    
 Ser Asp Cys Pro Ala Val Val Tyr Tyr Met Gly Gly Ser Val Val Lys
             100                 105                 110        
 Lys Lys Lys Leu Ile His Glu Gln Thr Leu Lys Lys Thr Val Gly
         115                 120                 125        



      <210> 1692
      <211> 143
      <212> PRT
      <213> Homo sapiens


      <400> 1692
 Met Leu Ile Thr Leu Ser Leu Met Gly Ala Tyr Val Pro Ile Lys Ala
   1               5                  10                  15    
 Met Lys Ser Ile Pro Val Pro Thr Asp Cys Ser Pro His Thr Pro Thr
              20                  25                  30        
 Gly Leu Glu Asp Cys Phe Val Ser Lys Ser Cys Leu Glu Cys Thr Ala
          35                  40                  45            
 Trp Phe Cys Pro Leu Asp Leu Gly Lys Val Thr Phe His Val Arg Glu
      50                  55                  60                
 Lys Gln Tyr Tyr Glu Met Leu Tyr Asn Thr Ala Asp Glu Leu Leu Asn
  65                  70                  75                  80
 Leu Val Val Asp Gln Gly Val Lys Tyr Thr Glu Leu Glu Tyr Ile His
                  85                  90                  95    
 Ala Leu Thr Leu Leu His Arg Ser Gln Thr Gly Val Gly Glu Leu Thr
             100                 105                 110        
 Thr Gln Asn Thr Arg Leu Gln Arg Leu Lys Glu Ile Ile Cys Glu Gln
         115                 120                 125            
 Ala Ala Ile Lys Gln Ala Thr Lys Asp Lys Lys Ile Thr Thr Val
     130                 135                 140            



      <210> 1693
      <211> 780
      <212> PRT
      <213> Homo sapiens


      <400> 1693
 Met Ala Leu Gly Gly Leu Thr Ala Cys Thr Val Val Leu Thr Thr Val
   1               5                  10                  15    
 Met Cys Ser Lys Ala Ile Lys Asn Asn Thr Ser Met Asp Ala Gln His
              20                  25                  30        
 Thr Gly Ala Ala Gln Lys His Val Thr Leu Lys Ala Ile Trp Trp Ala
          35                  40                  45            
 Lys Pro Asp Pro His Ala Gln Arg Met Glu Gly Arg Lys Ser His Asp
      50                  55                  60                
 Thr Gln Thr Cys Thr Thr Gly His Gln Leu Leu Gln Glu His Ile Pro
  65                  70                  75                  80
 Gln Arg Ser Gln His Gly Thr Thr Ile Ala Ile Thr Ile Ala Ser Ser
                  85                  90                  95    
 Gly Pro Gly Gly Ser Trp Gly Lys Leu His Leu Val Leu Ala Ala Tyr
             100                 105                 110        
 Phe Lys Ser Ala Val Pro Gln Cys Tyr Pro Val Pro Ala Ser Ala Ala
         115                 120                 125            
 Ala Pro Arg Gln Asp Thr Gly Pro Gln Pro Ser Cys Val Thr His Arg
     130                 135                 140                
 Thr His Lys Glu Met Val Ala Ser Ser Leu Thr Pro Glu Ala Phe Ala
 145                 150                 155                 160
 Asp Ser Leu Asp Gly Pro Cys Phe Trp Ser Asp Gly Asp Ser Cys Leu
                 165                 170                 175    
 Met Ala Leu Ala Gly Pro Cys Pro Ser Ser Thr Ala Ser Leu Leu Pro
             180                 185                 190        
 Ser Thr Gln Ala Leu Pro Thr Ile Asn Ser Phe Leu Lys Ile Ala Ser
         195                 200                 205            
 Lys Pro Lys Ser Thr Leu Asp Arg Ala Val Gly Lys Ala Ser Ser Ile
     210                 215                 220                
 Leu Ala Leu Lys Ser Arg Ala Ser Ala Lys Arg Ser Val Leu Leu Pro
 225                 230                 235                 240
 Ile Leu Ala Leu Trp Ala Gly Ser Cys Ser Gly Gly Ala Pro Pro Thr
                 245                 250                 255    
 Pro Met Gly Leu Ala Thr Leu Gln Leu Leu Pro Ser Pro Pro Gly Ala
             260                 265                 270        
 Pro Asp Gly Gln Leu Gln Pro Ile Pro Gly Ile Gly His Pro Asp Lys
         275                 280                 285            
 Pro Glu Ala Gly Lys Leu Asp Gln Leu Arg Asp Gln Pro Thr Pro Lys
     290                 295                 300                
 Gln Gly Ala Gln Gly Thr Pro Thr Gln Ser Pro Ser Thr Gly Trp Lys
 305                 310                 315                 320
 Ala Leu Pro Arg Pro Gly Leu Ala Leu Arg Lys Glu Ser Pro Pro Val
                 325                 330                 335    
 Thr Leu Glu Gln Glu Gln Gly His Asn Lys Gly Leu Val Ala Glu Trp
             340                 345                 350        
 Ala Gln Pro Gln Ala Thr Ala Ala Met Arg Ala Gly Ala Gly Lys Pro
         355                 360                 365            
 Glu Ala Leu Lys Leu Arg Pro Trp Gln Ala Gly Arg Asp Pro Gln Ala
     370                 375                 380                
 Gln Glu Gly Ala Ala Val Thr Glu Glu Asp Gln Gly Gln Arg Thr Gly
 385                 390                 395                 400
 Gly Arg Glu Asp Lys Gly Arg Gly Leu Lys Pro Arg Arg Pro Pro Lys
                 405                 410                 415    
 Gly Thr Ser His Gln Pro Gly Leu Arg Ile Arg Arg Pro Gln Lys Asp
             420                 425                 430        
 Arg Ser Arg Gly Gln Gly Gly Gly Gly Ser Thr Ser Lys Thr Pro Gly
         435                 440                 445            
 His Gly Trp Lys Arg Pro Gly Ser Thr His Gly His Arg His Arg His
     450                 455                 460                
 Ala Asp Leu Gly Thr Thr Gln Gln Ala Met Pro Ser Leu Pro Ala Ser
 465                 470                 475                 480
 Cys Leu Leu Ala Gln Ala Val Ile Ala Cys Gly Asn Val Lys Met Lys
                 485                 490                 495    
 His Val Pro Ala Leu Thr His Pro Gly Leu Thr Thr Leu Tyr Leu Ala
             500                 505                 510        
 Glu Asn Glu Ile Ala Lys Ile Pro Ala His Thr Phe Leu Gly Leu Pro
         515                 520                 525            
 Asn Leu Glu Trp Leu Asp Leu Ser Lys Asn Lys Leu Asp Pro Arg Gly
     530                 535                 540                
 Leu His Pro His Ala Phe Lys Asn Leu Met Arg Leu Lys Arg Leu Asn
 545                 550                 555                 560
 Leu Val Gly Asn Ser Leu Thr Thr Val Pro Ala Leu Pro Ala Ser Leu
                 565                 570                 575    
 Gln Glu Leu Lys Leu Asn Asp Asn Leu Leu Gln Gly Leu Gln Gly Ser
             580                 585                 590        
 Ser Phe Arg Gly Val Ala Asn Arg Gln Leu Pro Leu Pro Leu Cys Ala
         595                 600                 605            
 Pro Pro His Arg Lys Leu Glu Thr Leu Asp Leu Ser Tyr Asn Arg Leu
     610                 615                 620                
 Val His Val Pro Arg Phe Leu Pro Arg Gly Leu Arg Arg Leu Thr Leu
 625                 630                 635                 640
 His His Asp His Ile Glu Arg Ile Pro Gly Tyr Ala Phe Ala His Met
                 645                 650                 655    
 Lys Pro Gly Leu Glu Phe Leu His Leu Ser His Asn Arg Leu Gln Ala
             660                 665                 670        
 Asp Gly Ile His Ser Val Ser Phe Leu Gly Leu Arg Ala Ser Leu Ala
         675                 680                 685            
 Glu Leu Leu Leu Asp His Asn Gln Val Gln Ala Ile Pro Arg Gly Leu
     690                 695                 700                
 Leu Gly Leu Lys Gly Leu Gln Val Leu Gly Leu Ser His Asn Arg Ile
 705                 710                 715                 720
 Arg Gln Val Pro Leu Asn Ser Ile Cys Asp Met Arg Val Ala Gln Asp
                 725                 730                 735    
 Ser Asn Leu Thr Ser Thr His Leu Glu Asn Asn Leu Ile Asp Arg Arg
             740                 745                 750        
 Arg Ile Pro Pro Thr Ala Phe Ser Cys Thr Arg Ala Tyr His Ser Val
         755                 760                 765            
 Val Leu Gln Pro Gln Arg Arg Gly Glu Glu Gly Ser
     770                 775                 780



      <210> 1694
      <211> 178
      <212> PRT
      <213> Homo sapiens


      <400> 1694
 Met Leu Ser Val Leu Thr Thr Trp Gln Pro Val Phe Leu Ser Asp Arg
   1               5                  10                  15    
 Ser Lys Arg Lys His Arg Val Val Val Ser Tyr Pro Pro Gln Ser Glu
              20                  25                  30        
 Ala Glu Leu Glu Leu Lys Glu Gly Asp Ile Val Phe Val His Lys Lys
          35                  40                  45            
 Arg Glu Asp Gly Trp Phe Lys Gly Thr Leu Gln Arg Gln Asn Gly Glu
      50                  55                  60                
 Val Pro Arg Thr Val Phe Leu Leu Cys Ser Thr Lys Thr Ser Arg Glu
  65                  70                  75                  80
 Pro Asp Asn Ser Leu Leu Ile Leu Lys Asp Ser Lys Ser Arg Pro Gln
                  85                  90                  95    
 Ile Cys Val Ser Gln Ile Ala Lys His Val Pro Leu Pro Ser Trp Lys
             100                 105                 110        
 Pro Gly Leu Arg Glu Met Arg Leu Val Gln Gln Pro Val Tyr Ala Gln
         115                 120                 125            
 Gly Lys Pro Glu His Val Ser Glu Val Ser Leu Ala Trp Asp Pro Ala
     130                 135                 140                
 Ser Gly Lys Leu Arg Gly Ile Ser Gly Ala Ser Trp Asp Gly Ser Asn
 145                 150                 155                 160
 Gly Pro Trp Pro Pro Leu Ser Phe Thr Pro Pro His Pro Asn Gln Arg
                 165                 170                 175    
 Asp Gln
        



      <210> 1695
      <211> 303
      <212> PRT
      <213> Homo sapiens


      <400> 1695
 Met Pro Gln Ser His Gln Trp Ala Phe Pro Leu Cys Gln Leu Lys Leu
   1               5                  10                  15    
 Thr Phe Leu Ser Leu Thr Val Lys Ala Phe Gln Asp Leu Ala Phe Ile
              20                  25                  30        
 Cys Ile Leu Glu Tyr Val Ser Lys Ser Val Tyr Leu Lys Thr Val Ile
          35                  40                  45            
 Asn Gln Ser Tyr Asn Val Ala Asp Thr Val Ile Asn Ile Asn Lys Leu
      50                  55                  60                
 Arg Asn Met Glu Cys Asn Leu Gly Gln Asp Asn Glu Pro Ala Lys Ala
  65                  70                  75                  80
 Pro Gly Leu Pro Thr Ser Leu Pro Val Pro Gly Ala Pro Thr Ala Ala
                  85                  90                  95    
 Gln Glu Ala Ala Val Pro Gly Tyr Leu Gln Val Pro Ala Pro Gly Arg
             100                 105                 110        
 Gln Gly Ala Ala Ala Pro Lys Pro Arg Leu Arg Ile Phe Pro Lys Arg
         115                 120                 125            
 Ala Glu Phe Arg Ser Pro Pro Pro Cys Gly Gly Arg Pro Thr Asn Ala
     130                 135                 140                
 Asp Arg Thr Pro Leu Val Leu Pro Cys Arg Thr Pro Pro Arg Leu Gly
 145                 150                 155                 160
 Pro Glu Ser Pro Ala Leu Arg Ala Gln Pro Ser Gln His Arg Gly Pro
                 165                 170                 175    
 His Thr Pro Ala Ser Ser Pro Gly Ser Gly Ser Met Thr Pro Gln His
             180                 185                 190        
 Arg Ser Pro Gly His Pro Thr Thr Ala Val Gln Ser Ser Arg Ala Pro
         195                 200                 205            
 Gln His Pro Asn Pro Ser Ser Pro Leu Pro Gly Leu Asp Ser Glu Thr
     210                 215                 220                
 Gln His Arg Gly Pro Lys Leu Arg Pro Leu Ala Ser Ala Arg Ala Ala
 225                 230                 235                 240
 Ala Ala Ala Ala Arg Lys Leu Thr Asp Ala Ala Ser Phe His Pro Gly
                 245                 250                 255    
 Arg Arg Pro Ser Gln Ser Leu Val Ala Ala Lys Asn Pro Glu Ser Leu
             260                 265                 270        
 Arg Gln Arg Arg Leu Asn Arg Pro His Ile Leu Ser Lys Asn Ser Pro
         275                 280                 285            
 Leu Arg Gly Pro Phe Pro Lys Ser Leu Gly Lys Gly Gly Lys Gln
     290                 295                 300            



      <210> 1696
      <211> 307
      <212> PRT
      <213> Homo sapiens


      <400> 1696
 Met Gln Met Glu Lys Arg Glu Leu Ser Glu Ala Glu Val Leu Glu Val
   1               5                  10                  15    
 Gln Phe Gln Leu Lys Val Gly Ile Val Ser Leu Ile Ile Trp Phe Leu
              20                  25                  30        
 Ile Leu Lys Val Trp Pro Leu Ile Ala Ala Trp Ala Ser Pro Gly Gly
          35                  40                  45            
 Leu Leu Glu Ala Glu Ser Gln Val Leu Pro Gln Thr Cys Glu Ser Glu
      50                  55                  60                
 Leu Ala Leu Lys Glu Asp Pro Lys Ile Thr Arg Met His Ile Thr Phe
  65                  70                  75                  80
 Gly Glu Val Leu Leu Lys Ser Val Ser Gln Ser Val Phe Cys Gly Thr
                  85                  90                  95    
 Ser Thr Tyr Cys Val Leu Asn Thr Val Pro Pro Ile Glu Asp Asp His
             100                 105                 110        
 Gly Asn Ser Asn Ser Ser His Val Lys Ile Phe Leu Pro Lys Lys Leu
         115                 120                 125            
 Leu Glu Cys Leu Pro Lys Cys Ser Ser Leu Pro Lys Glu Arg His Arg
     130                 135                 140                
 Trp Asn Thr Asn Glu Gln Gln Gln Gln Gln Gln His Ser Thr Gly Tyr
 145                 150                 155                 160
 Ile Glu Lys Leu Gly Arg Asn Val Leu Pro His Arg Ala Ala Val Glu
                 165                 170                 175    
 Lys His Cys Ser Leu Gly Lys Gly Ala Glu Leu Val Ser Glu Ala Asp
             180                 185                 190        
 Ser Ser Leu Gly Ser Ala Ala Thr Gln Leu Ser Val Gly Leu Ser Pro
         195                 200                 205            
 Ser Leu Ser Cys Cys Ser Phe Tyr Ser Leu Arg Phe Leu Asp Val His
     210                 215                 220                
 Ser Ile Pro Tyr Pro Val Leu Glu His Cys Glu Met Ser Ile Pro Asp
 225                 230                 235                 240
 Lys Trp Ser Ser Asn Leu Glu Arg Gln Tyr Phe Thr Arg Ser Ala Gly
                 245                 250                 255    
 Gln Gln Leu Met Val Gln Gly Leu Leu Phe Ala Asp Lys Ala Gly Ser
             260                 265                 270        
 Trp Gly Lys Lys Leu Val Thr Glu Ala Ala Arg Gly Gln Ala Gly Thr
         275                 280                 285            
 Leu Trp His Leu Arg Leu Tyr Leu Leu Pro Pro Leu Thr Thr Ser Ala
     290                 295                 300                
 Leu Arg Lys
 305        



      <210> 1697
      <211> 140
      <212> PRT
      <213> Homo sapiens


      <400> 1697
 Met Val Pro Leu His Tyr Gln Lys Leu Arg Asn Glu Val Gln Gln Cys
   1               5                  10                  15    
 Ala Ser Arg His Cys Leu Leu Leu Ile Ser Thr Leu Gly Val Phe Ala
              20                  25                  30        
 Leu Asn Cys Phe Thr Lys Gly Gln Lys Asn Ser Thr Leu Ile Phe Thr
          35                  40                  45            
 Arg Glu Asn Thr Ile Arg Asn Cys Ser Cys Ser Ala Asp Ile Arg Asp
      50                  55                  60                
 Cys Asp Tyr Ser Leu Ala Asn Leu Met Cys Asn Cys Lys Thr Val Leu
  65                  70                  75                  80
 Pro Leu Ala Val Glu Arg Thr Ser Tyr Asn Gly His Leu Thr Ile Trp
                  85                  90                  95    
 Phe Thr Asp Thr Ser Ala Leu Gly His Leu Leu Asn Phe Thr Leu Val
             100                 105                 110        
 Gln Asp Leu Lys Leu Ser Leu Pro Cys Ser Ser Pro Phe Phe Asn Ile
         115                 120                 125            
 Glu Ser His Asp Ser Pro Leu Val Gln Leu Gly Ser
     130                 135                 140



      <210> 1698
      <211> 380
      <212> PRT
      <213> Homo sapiens


      <400> 1698
 Met Glu Cys Leu Arg Ser Leu Pro Cys Leu Leu Pro Arg Ala Met Arg
   1               5                  10                  15    
 Leu Pro Arg Arg Thr Leu Cys Ala Leu Ala Leu Asp Val Thr Ser Val
              20                  25                  30        
 Gly Pro Pro Val Ala Ala Cys Gly Arg Arg Ala Asn Leu Ile Gly Arg
          35                  40                  45            
 Ser Arg Ala Ala Gln Leu Cys Gly Pro Asp Arg Leu Arg Val Ala Glu
      50                  55                  60                
 Arg Lys Lys Thr Glu Leu Tyr Gln Glu Leu Gly Leu Gln Ala Arg Asp
  65                  70                  75                  80
 Leu Arg Phe Gln His Val Met Ser Ile Thr Val Arg Asn Asn Arg Ile
                  85                  90                  95    
 Ile Met Arg Met Glu Tyr Leu Lys Ala Val Ile Thr Pro Glu Cys Leu
             100                 105                 110        
 Leu Ile Leu Asp Tyr Arg Asn Leu Asn Leu Glu Gln Trp Leu Phe Arg
         115                 120                 125            
 Glu Leu Pro Ser Gln Leu Ser Gly Glu Gly Gln Leu Val Thr Tyr Pro
     130                 135                 140                
 Leu Pro Phe Glu Phe Arg Ala Ile Glu Ala Leu Leu Gln Tyr Trp Asn
 145                 150                 155                 160
 Arg Trp Leu His Phe Leu Leu Gly Val Ile Asn Glu His Gln Leu Ala
                 165                 170                 175    
 Pro Ala Ser Glu Met Ile Ser Ser Gly Ser Pro Val Thr Lys Gln Gly
             180                 185                 190        
 Glu Ser Arg Arg Glu Lys Glu Asp Val Asn Ser Gly Lys Ser Trp Ala
         195                 200                 205            
 Pro Gln Ala Gly Leu Ser Glu Leu Glu Thr Asp Ile Lys Ile Phe Lys
     210                 215                 220                
 Glu Ser Ile Leu Glu Ile Leu Asp Glu Glu Glu Leu Leu Glu Glu Leu
 225                 230                 235                 240
 Cys Val Ser Lys Trp Ser Asp Pro Gln Val Phe Glu Lys Ser Ser Ala
                 245                 250                 255    
 Gly Ile Asp His Ala Glu Glu Met Glu Leu Leu Leu Glu Asn Tyr Tyr
             260                 265                 270        
 Arg Leu Ala Asp Asp Leu Ser Asn Ala Ala Arg Glu Leu Arg Val Leu
         275                 280                 285            
 Ile Asp Asp Ser Gln Ser Ile Ile Phe Ile Asn Leu Asp Ser His Arg
     290                 295                 300                
 Asn Val Met Met Arg Leu Asn Leu Gln Leu Thr Met Gly Thr Phe Ser
 305                 310                 315                 320
 Leu Ser Leu Phe Gly Leu Met Gly Val Ala Phe Gly Met Asn Leu Glu
                 325                 330                 335    
 Ser Ser Leu Glu Glu Asp His Arg Ile Phe Trp Leu Ile Thr Gly Ile
             340                 345                 350        
 Met Phe Met Gly Ser Gly Leu Ile Trp Arg Arg Leu Leu Ser Phe Leu
         355                 360                 365            
 Gly Arg Gln Leu Glu Ala Pro Leu Pro Pro Met Val
     370                 375                 380



      <210> 1699
      <211> 273
      <212> PRT
      <213> Homo sapiens


      <400> 1699
 Met Leu Cys Ser Leu Leu Leu Phe Gly Cys Lys Pro Ala Leu His Val
   1               5                  10                  15    
 Thr Val Leu Asn Thr Ile Gly Ser Cys Asn Asn Glu Cys Gln Leu Cys
              20                  25                  30        
 Leu His Ile Pro Ser Pro Leu Lys Phe Ile Ser Ile Lys Ala Val Ser
          35                  40                  45            
 Met Ser Ser Val Ala Ser Ser Met Ser Phe Thr Lys Val Leu Asn Trp
      50                  55                  60                
 Asp Pro Ser Val Ser Lys Ser Val Glu Arg Ile Phe Lys Ile Trp Glu
  65                  70                  75                  80
 Asp Arg Asn Val Tyr Pro Glu Glu Met Ile Val Ala Leu Arg Glu Ala
                  85                  90                  95    
 Leu Ser Thr Thr Phe Lys Thr Gln Lys Gln Leu Lys Glu Asn Leu Asn
             100                 105                 110        
 Lys Gln Pro Asn Lys Gln Trp Lys Lys Ser Gln Thr Ser Thr Asn Pro
         115                 120                 125            
 Lys Ala Ala Leu Lys Ser Lys Ile Val Ala Glu Phe Arg Ser Gln Ala
     130                 135                 140                
 Leu Ile Glu Glu Leu Leu Leu Tyr Lys Arg Ser Glu Asp Gln Ile Glu
 145                 150                 155                 160
 Leu Lys Glu Lys Gln Leu Ser Thr Met Arg Val Asp Val Cys Ser Thr
                 165                 170                 175    
 Glu Thr Leu Lys Cys Leu Lys Asp Lys Thr Gly Gly Lys Lys Phe Ser
             180                 185                 190        
 Lys Glu Phe Glu Glu Ala Ser Ser Lys Leu Glu Glu Phe Val Asn Gly
         195                 200                 205            
 Leu Asp Lys Gln Val Lys Asn Gly Pro Ser Leu Thr Glu Ala Leu Glu
     210                 215                 220                
 Asn Ala Gly Ile Phe Tyr Glu Ala Gln Tyr Lys Glu Val Lys Val Val
 225                 230                 235                 240
 Ala Asn Cys Trp Asp Cys Arg Cys Glu Pro Pro Ser Leu Ala Leu Leu
                 245                 250                 255    
 Phe Phe Leu Thr Arg Lys Leu Asp Gly Asn Ile Leu Leu Pro Asn Phe
             260                 265                 270        
 Met
    



      <210> 1700
      <211> 281
      <212> PRT
      <213> Homo sapiens


      <400> 1700
 Met Ser Leu Lys Phe Phe Tyr Ile Phe Leu Thr Ser Ser Pro Ser Leu
   1               5                  10                  15    
 Lys Thr Thr Ala Val Ser Ile Val Gln Ile Tyr Val Glu Thr Cys Gly
              20                  25                  30        
 Ile Gln Arg Ile Asp Asp Ile Val Lys Ala Val Gly Asn Cys Ser Tyr
          35                  40                  45            
 Asn Gln Leu Val Glu Lys Ile Ile Ser Cys Lys Gln Ser Asp Asn Ser
      50                  55                  60                
 Glu Leu Val Ser Glu Gly Phe Val Ala Glu Gln Phe Leu Asn Asn Thr
  65                  70                  75                  80
 Ala Thr Gln Leu Thr Tyr His Gly Leu Cys Glu Leu Thr Ser Thr Val
                  85                  90                  95    
 Gln Glu Gly Glu Leu Cys Val Phe Phe Arg Asn Asn His Phe Ser Thr
             100                 105                 110        
 Met Thr Lys Tyr Lys Gly Gln Leu Tyr Leu Leu Val Thr Asp Gln Gly
         115                 120                 125            
 Phe Leu Thr Glu Glu Lys Val Val Trp Glu Ser Leu His Asn Val Asp
     130                 135                 140                
 Gly Asp Gly Asn Phe Cys Asp Ser Glu Phe His Leu Arg Pro Pro Ser
 145                 150                 155                 160
 Asp Pro Glu Thr Val Tyr Lys Gly Gln Gln Asp Gln Ile Asp Gln Asp
                 165                 170                 175    
 Tyr Leu Met Ala Leu Ser Leu Gln Gln Glu Gln Gln Ser Gln Glu Ile
             180                 185                 190        
 Asn Trp Glu Gln Ile Pro Glu Gly Ile Ser Asp Leu Glu Leu Ala Lys
         195                 200                 205            
 Lys Leu Gln Glu Glu Glu Asp Arg Arg Ala Ser Gln Tyr Tyr Gln Glu
     210                 215                 220                
 Gln Glu Gln Ala Ala Ala Ala Ala Ala Ala Ala Ser Thr Gln Ala Gln
 225                 230                 235                 240
 Gly Gln Pro Ala Gln Ala Ser Pro Ser Ser Gly Arg Gln Ser Gly Asn
                 245                 250                 255    
 Ser Glu Arg Lys Arg Lys Glu Pro Arg Glu Lys Asp Lys Glu Lys Glu
             260                 265                 270        
 Lys Glu Lys Asn Ser Cys Val Ile Leu
         275                 280    



      <210> 1701
      <211> 185
      <212> PRT
      <213> Homo sapiens


      <400> 1701
 Met Met Trp Pro Met His Thr Pro Leu Leu Leu Leu Thr Ala Leu Met
   1               5                  10                  15    
 Val Ala Val Ala Gly Ser Ala Ser Ala Gln Ser Arg Thr Leu Ala Gly
              20                  25                  30        
 Gly Ile His Ala Thr Asp Leu Asn Asp Lys Ser Val Gln Cys Ala Leu
          35                  40                  45            
 Asp Phe Ala Ile Ser Glu Tyr Asn Lys Val Ile Asn Lys Asp Glu Tyr
      50                  55                  60                
 Tyr Ser Arg Pro Leu Gln Val Met Ala Ala Tyr Gln Gln Pro Ser Pro
  65                  70                  75                  80
 Cys Thr Gly Gly Ala Phe Pro Gly Ala Val Val Pro Ala Gly Leu His
                  85                  90                  95    
 Ser Leu Leu Ser Val Ser Leu Thr Gly Ser Glu Ala Gln Asn Asp Val
             100                 105                 110        
 Asp Arg Trp Ala Leu Glu Pro Ile Leu Gln Ser Ser Arg Leu Thr Pro
         115                 120                 125            
 Glu Gly Ser Gln Asp Phe His Val Val Leu Gln Asp Leu Thr His Lys
     130                 135                 140                
 Val Gln Ala Asn Val Glu Arg Ser Val Gln Lys Pro Leu Leu Cys Ser
 145                 150                 155                 160
 Ser Val Leu Leu Cys Lys Gly Gly Pro Arg Ser Ser Arg Gln Trp Asp
                 165                 170                 175    
 Val Leu Leu Thr His Lys Gln Ser Phe
             180                 185



      <210> 1702
      <211> 134
      <212> PRT
      <213> Homo sapiens


      <400> 1702
 Met Leu Arg Pro Glu Leu Val Val Lys Lys Leu Arg Tyr Tyr Ala Arg
   1               5                  10                  15    
 Phe Ile Val Val Cys Leu Leu Leu Asn Lys Met Asp Val Val Lys Asp
              20                  25                  30        
 Leu Val Lys Glu Leu Ser Asp Glu Ile Glu Asp Tyr Thr His Arg Phe
          35                  40                  45            
 Asn Thr Glu Asp Gln Val Glu Trp Asn Leu Val Leu Gln Glu Val Ala
      50                  55                  60                
 Ala Phe Ile Glu Ala Asp Pro Val Met Val Leu Asn Asp Asp Asn Thr
  65                  70                  75                  80
 Ile Val Ile Thr Ser Asn Arg Leu Ala Glu Thr Gly Ala Pro Leu Leu
                  85                  90                  95    
 Glu Gln Gly Met Ile Val Gly Gln Leu Ser Leu Ala Asp Ala Leu Ile
             100                 105                 110        
 Ile Gly Asn Cys Asn Asn Gln Val Lys Asn Cys Glu Gly Ile Met Leu
         115                 120                 125            
 Lys Ile His Cys Glu Lys
     130                



      <210> 1703
      <211> 311
      <212> PRT
      <213> Homo sapiens


      <400> 1703
 Met Ala Leu Phe Thr Pro Trp Lys Leu Ser Ser Gln Lys Leu Gly Phe
   1               5                  10                  15    
 Phe Leu Val Thr Phe Gly Phe Ile Trp Gly Met Met Leu Leu His Phe
              20                  25                  30        
 Thr Ile Gln Gln Arg Thr Gln Pro Glu Ser Ser Ser Met Leu Arg Glu
          35                  40                  45            
 Gln Ile Leu Asp Leu Ser Lys Arg Tyr Ile Lys Ala Leu Ala Glu Glu
      50                  55                  60                
 Asn Arg Asn Val Val Asp Gly Pro Tyr Ala Gly Val Met Thr Ala Tyr
  65                  70                  75                  80
 Ala Asn Lys Tyr Asp Thr Gly Thr Cys Met Leu Gly Ile Gly Gly Gly
                  85                  90                  95    
 Gly Val Ser Gly Met Val Gln Gln Ala Gly Ser Ser Ser Val Arg Gly
             100                 105                 110        
 His Pro Phe Gln Glu Asp Leu Lys Lys Thr Leu Ala Val Leu Leu Asp
         115                 120                 125            
 Asn Ile Leu Gln Arg Ile Gly Lys Leu Glu Ser Lys Val Asp Asn Leu
     130                 135                 140                
 Val Val Asn Gly Thr Gly Thr Asn Ser Thr Asn Ser Thr Thr Ala Val
 145                 150                 155                 160
 Pro Ser Leu Val Ala Leu Glu Lys Ile Asn Val Ala Ala Val Phe Cys
                 165                 170                 175    
 Val Ala Phe Ile Gln Lys Pro Asp Leu Val Lys Gly Leu Ser Arg Ser
             180                 185                 190        
 Tyr Leu Ala Val Thr Ala Trp Thr Trp Ser Leu Ala Ser Asp Ile Phe
         195                 200                 205            
 Glu Gln Asn Ser Gly Ser Thr Tyr Ile Leu Ala Val Ser Ile Leu Leu
     210                 215                 220                
 Tyr Leu Thr Ile Ala Asp Pro Pro Ile His Ala Leu Cys Asn Gly Gly
 225                 230                 235                 240
 Ser Asp Thr Asn Thr Val Leu Met Lys Leu Phe Ser Val Trp Arg Met
                 245                 250                 255    
 Trp Ile Gln Arg Phe Met Ser Phe Tyr Lys Trp Lys Arg Phe Arg Cys
             260                 265                 270        
 Ser Asn Ile Ser Ser Lys Trp Glu Ile Ala Thr Phe Gln Asn Pro Trp
         275                 280                 285            
 Trp Met Val Leu Gln Ile Tyr Leu Asn Ser Ser Ser Ala Gly Thr Phe
     290                 295                 300                
 Ser Cys His Thr Val Glu Leu
 305                 310    



      <210> 1704
      <211> 373
      <212> PRT
      <213> Homo sapiens


      <400> 1704
 Met Glu Val Val Leu Ile Phe Leu Cys Ser Leu Leu Ala His Ile Val
   1               5                  10                  15    
 Leu Ala Asp Ala Val Glu Arg Glu Lys Gln Ile Asp Pro Phe His Tyr
              20                  25                  30        
 Asp Tyr Gln Thr Leu Arg Ile Arg Gly Tyr Phe Asn Glu Asn Ala Lys
          35                  40                  45            
 Asn Ile Arg Cys Tyr Leu Asp Leu Met Met Gln Asn Val Gly Arg Thr
      50                  55                  60                
 Ala His Lys Leu Glu Ser Phe Met Leu Tyr Phe Ser Leu Asp Gln Ala
  65                  70                  75                  80
 Cys Leu Cys Leu Tyr Ala Asn Ile Asn His Asn Leu Ser Leu Thr Tyr
                  85                  90                  95    
 Gly Ala Leu Asp His Gln Val Lys Ala Leu Asn Val Leu Arg Val Leu
             100                 105                 110        
 Cys Tyr Leu Glu Ser Gln Glu Cys Gln Ile Thr Thr Tyr Tyr Tyr Val
         115                 120                 125            
 Gly Phe Ala Tyr Leu Met Met Cys Arg Tyr Gln Asp Ala Ile Arg Val
     130                 135                 140                
 Phe Ala Asn Ser Leu Leu Tyr Ile Gln Arg Thr Lys Ser Met Phe Gln
 145                 150                 155                 160
 Arg Thr Thr Tyr Lys Tyr Glu Met Ile Asn Lys Gln Asn Glu Gln Met
                 165                 170                 175    
 His Ala Leu Leu Ala Ile Ala Leu Thr Val Tyr Pro Met Ser Ile Asp
             180                 185                 190        
 Glu Ser Ile His Leu Gln Leu Gln Lys Lys His Arg Asp Lys Met Leu
         195                 200                 205            
 Arg Met Gln Lys Gly Asp Pro Gln Val Tyr Glu Glu Leu Phe Ser Tyr
     210                 215                 220                
 Phe Cys Pro Lys Phe Leu Ser Pro Val Val Pro Asn Tyr Asp Asn Val
 225                 230                 235                 240
 His Pro Asn Tyr His Lys Glu Pro Phe Leu Gln Gln Leu Lys Val Phe
                 245                 250                 255    
 Ser Asp Glu Val Gln Gln Gln Ala Gln Leu Ser Thr Ile His Ser Phe
             260                 265                 270        
 Leu Lys Leu Tyr Thr Thr Met Pro Val Ala Lys Leu Ala Gly Phe Leu
         275                 280                 285            
 Asp Leu Thr Glu Gln Glu Phe Arg Ile Gln Leu Leu Val Phe Lys His
     290                 295                 300                
 Lys Met Lys Asn Leu Val Trp Thr Ser Gly Ile Ser Ile Leu Asp Gly
 305                 310                 315                 320
 Glu Phe Gln Ser Ala Ser Glu Val Asp Phe Tyr Ile Asp Lys Asp Met
                 325                 330                 335    
 Ile His Ile Ala Asp Thr Lys Val Ser Arg Arg Tyr Gly Asp Phe Phe
             340                 345                 350        
 Ile Arg Arg Ile Gln Lys Leu Glu Glu Leu Asn Arg Thr Leu Lys Lys
         355                 360                 365            
 Met Gly Gln Arg Pro
     370            



      <210> 1705
      <211> 231
      <212> PRT
      <213> Homo sapiens


      <400> 1705
 Met Asp Gln Arg Trp Lys Leu Thr Ser Lys Phe Thr His Ile His Asn
   1               5                  10                  15    
 Tyr Ala Leu Leu Cys Thr Ile Leu Phe Leu Ala Thr Tyr Arg Glu Lys
              20                  25                  30        
 Val Leu Val Ala Cys His Ser Leu Asp Thr Ala Gln Gln Cys Val Pro
          35                  40                  45            
 Asp Thr Arg Tyr Leu Gly Ser Tyr Gln Glu Glu Met Asn Thr Glu Gly
      50                  55                  60                
 Glu Glu Glu Cys Thr Leu Asp Ile Ile Val Ile Thr Gln Glu Phe Leu
  65                  70                  75                  80
 Ser Ser Arg Trp Leu Ile Ser Tyr Thr Val Asp Leu Glu Asp Ser Thr
                  85                  90                  95    
 Ile Ile Thr Lys Ile Arg Asn Leu Glu Leu His His Asp Lys Ile Leu
             100                 105                 110        
 Asn Asn His Arg Lys Asn Phe Phe Arg Tyr Ser Thr Pro Tyr Asp Ala
         115                 120                 125            
 Asn Gln Tyr Pro Lys Asn Lys Gly Glu Asn Ala Gln Gln His Glu Glu
     130                 135                 140                
 Gly Thr Ile Phe Ile Thr Asn Val Arg Asp Lys Ala Ile Lys Lys Phe
 145                 150                 155                 160
 Val Ile Gln Asn Thr Val Glu Ala Thr Ala Val Arg Asp Ile Ser Glu
                 165                 170                 175    
 Ala Ser Ile Phe Asp Ala Tyr Val Leu Pro Lys Met Tyr Val Lys Leu
             180                 185                 190        
 Asn Tyr Cys Pro Asn Ala Ala Glu Gly Ser Arg Leu Leu Val Glu Ser
         195                 200                 205            
 Arg Pro Asn Ser Thr Glu Glu Ser Arg Val Arg Glu Asp Gly Ser Gln
     210                 215                 220                
 Pro Asn Val Ala Glu Glu Ser
 225                 230    



      <210> 1706
      <211> 967
      <212> PRT
      <213> Homo sapiens


      <400> 1706
 Met Arg Thr Arg Leu Tyr Leu Asn Leu Gly Leu Thr Phe Glu Ser Leu
   1               5                  10                  15    
 Gln Gln Thr Ala Leu Cys Asn Asp Tyr Phe Arg Lys Ser Ile Phe Leu
              20                  25                  30        
 Ala Glu Gln Asn His Leu Tyr Glu Asp Leu Phe Arg Ala Arg Tyr Asn
          35                  40                  45            
 Leu Gly Thr Ile His Trp Arg Ala Gly Gln His Ser Gln Ala Met Arg
      50                  55                  60                
 Cys Leu Glu Gly Ala Arg Glu Cys Ala His Thr Met Arg Lys Arg Phe
  65                  70                  75                  80
 Met Glu Ser Glu Cys Cys Val Val Ile Ala Gln Val Pro Ala Val Arg
                  85                  90                  95    
 Gly Ser Glu Leu Arg Leu Ser Ser Ser Lys Thr Trp Glu Thr Phe Leu
             100                 105                 110        
 Ala Ala Lys Arg Ala Leu Lys Lys Ala Tyr Arg Leu Gly Ser Gln Lys
         115                 120                 125            
 Pro Val Gln Arg Ala Ala Ile Cys Gln Asn Leu Gln His Val Leu Ala
     130                 135                 140                
 Val Val Arg Leu Gln Gln Gln Leu Glu Glu Ala Glu Gly Arg Asp Pro
 145                 150                 155                 160
 Gln Gly Ala Met Val Ile Cys Glu Gln Leu Gly Asp Leu Phe Ser Lys
                 165                 170                 175    
 Ala Gly Asp Phe Pro Arg Ala Ala Glu Ala Tyr Gln Lys Gln Leu Arg
             180                 185                 190        
 Phe Ala Glu Leu Leu Asp Arg Pro Gly Ala Glu Arg Ala Ile Ile His
         195                 200                 205            
 Val Ser Leu Ala Thr Thr Leu Gly Asp Met Lys Asp His His Gly Ala
     210                 215                 220                
 Val Arg His Tyr Glu Glu Glu Leu Arg Leu Arg Ser Gly Asn Val Leu
 225                 230                 235                 240
 Glu Glu Ala Lys Thr Trp Leu Asn Ile Ala Leu Ser Arg Glu Glu Ala
                 245                 250                 255    
 Gly Asp Ala Tyr Glu Leu Leu Ala Pro Cys Phe Gln Lys Ala Leu Ser
             260                 265                 270        
 Cys Ala Gln Gln Ala Gln Arg Pro Gln Leu Gln Arg Gln Val Leu Gln
         275                 280                 285            
 His Leu His Thr Val Gln Leu Arg Leu Gln Pro Gln Glu Ala Pro Glu
     290                 295                 300                
 Thr Glu Thr Arg Leu Arg Glu Leu Ser Val Ala Glu Asp Glu Asp Glu
 305                 310                 315                 320
 Glu Glu Glu Ala Glu Glu Ala Ala Ala Thr Ala Glu Ser Glu Ala Leu
                 325                 330                 335    
 Glu Ala Gly Glu Met Glu Leu Ser Glu Gly Glu Asp Asp Thr Asp Gly
             340                 345                 350        
 Leu Thr Pro Gln Leu Glu Glu Asp Glu Glu Leu Gln Gly His Leu Gly
         355                 360                 365            
 Arg Arg Lys Gly Ser Lys Trp Asn Arg Arg Asn Asp Met Gly Glu Thr
     370                 375                 380                
 Leu Leu His Arg Ala Cys Ile Glu Gly Gln Leu Arg Arg Val Gln Asp
 385                 390                 395                 400
 Leu Val Arg Gln Gly His Pro Leu Asn Pro Arg Asp Tyr Cys Gly Trp
                 405                 410                 415    
 Thr Pro Leu His Glu Ala Cys Asn Tyr Gly His Leu Glu Ile Val Arg
             420                 425                 430        
 Phe Leu Leu Asp His Gly Ala Ala Val Asp Asp Pro Gly Gly Gln Gly
         435                 440                 445            
 Cys Glu Gly Ile Thr Pro Leu His Asp Ala Leu Asn Cys Gly His Phe
     450                 455                 460                
 Glu Val Ala Glu Leu Leu Leu Glu Arg Gly Ala Ser Val Thr Leu Arg
 465                 470                 475                 480
 Thr Arg Lys Gly Leu Ser Pro Leu Glu Thr Leu Gln Gln Trp Val Lys
                 485                 490                 495    
 Leu Tyr Arg Arg Asp Leu Asp Leu Glu Thr Arg Gln Lys Ala Arg Ala
             500                 505                 510        
 Met Glu Met Leu Leu Gln Ala Ala Ala Ser Gly Gln Gly Lys Gln Gly
         515                 520                 525            
 Val Pro Cys Pro Trp Gly Cys Cys Ala Tyr Ala Glu Ser Pro Arg Ala
     530                 535                 540                
 Leu Ile Ser Gly Asp Ala Pro Ser Gln Ala Ala Leu Ile Pro Glu Glu
 545                 550                 555                 560
 Glu Cys Leu Ala Gly Asp Trp Leu Glu Leu Asp Met Pro Leu Thr Arg
                 565                 570                 575    
 Ser Arg Arg Pro Arg Pro Arg Gly Thr Gly Asp Asn Arg Arg Pro Ser
             580                 585                 590        
 Ser Thr Ser Gly Ser Asp Thr His Ser Val Ala Trp Leu Ala Glu Gln
         595                 600                 605            
 Ala Ala Gln Arg Tyr Tyr Gln Thr Cys Gly Leu Leu Pro Arg Leu Thr
     610                 615                 620                
 Leu Arg Lys Glu Gly Ala Leu Leu Ala Pro Gln Asp Leu Ile Pro Asp
 625                 630                 635                 640
 Val Leu Gln Ser Asn Asp Glu Val Leu Ala Glu Val Thr Ser Trp Asp
                 645                 650                 655    
 Leu Pro Pro Leu Thr Asp Arg Tyr Arg Arg Ala Cys Gln Ser Leu Gly
             660                 665                 670        
 Gln Gly Glu His Gln Gln Val Leu Gln Ala Val Glu Leu Gln Gly Leu
         675                 680                 685            
 Gly Leu Ser Phe Ser Ala Cys Ser Leu Ala Leu Asp Gln Ala Gln Leu
     690                 695                 700                
 Thr Pro Leu Leu Arg Ala Leu Lys Leu His Thr Ala Leu Arg Glu Leu
 705                 710                 715                 720
 Arg Leu Ala Gly Asn Arg Leu Gly Asp Lys Cys Val Ala Glu Leu Val
                 725                 730                 735    
 Ala Ala Leu Gly Thr Met Pro Ser Leu Ala Leu Leu Asp Leu Ser Ser
             740                 745                 750        
 Asn His Leu Gly Pro Glu Gly Leu Arg Gln Leu Ala Met Gly Leu Pro
         755                 760                 765            
 Gly Gln Ala Thr Leu Gln Ser Leu Glu Glu Leu Asp Leu Ser Met Asn
     770                 775                 780                
 Pro Leu Gly Asp Gly Cys Gly Gln Ser Leu Ala Ser Leu Leu His Ala
 785                 790                 795                 800
 Cys Pro Leu Leu Ser Thr Leu Arg Leu Gln Ala Cys Gly Phe Gly Pro
                 805                 810                 815    
 Ser Phe Phe Leu Ser His Gln Thr Ala Leu Gly Ser Ala Phe Gln Asp
             820                 825                 830        
 Ala Glu His Leu Lys Thr Leu Ser Leu Ser Tyr Asn Ala Leu Gly Ala
         835                 840                 845            
 Pro Ala Leu Ala Arg Thr Leu Gln Ser Leu Pro Ala Gly Thr Leu Leu
     850                 855                 860                
 His Leu Glu Leu Ser Ser Val Ala Ala Gly Lys Gly Asp Ser Asp Leu
 865                 870                 875                 880
 Met Glu Pro Val Phe Arg Tyr Leu Ala Lys Gly Gln Ala Ala Phe Ser
                 885                 890                 895    
 Arg Lys Ala Pro Glu Cys Trp Cys Cys Ala Val Gln Gly Pro Leu Gly
             900                 905                 910        
 Leu Gly Leu Trp Asp Lys Ile Ala Ala Gln Leu Arg Glu Leu Gln Leu
         915                 920                 925            
 Cys Ser Arg Arg Leu Cys Ala Glu Asp Arg Asp Ala Leu Arg Gln Leu
     930                 935                 940                
 Gln Pro Ser Arg Pro Gly Pro Gly Glu Cys Thr Leu Asp His Gly Ser
 945                 950                 955                 960
 Lys Leu Phe Phe Arg Arg Leu
                 965        



      <210> 1707
      <211> 181
      <212> PRT
      <213> Homo sapiens


      <400> 1707
 Met Cys Leu Phe Ser Val Ala Val Phe Phe Ile Glu Ala Cys Lys Pro
   1               5                  10                  15    
 Gln Gly Pro Arg Glu Ser Gln Gln Asp Gly Ser His Ala Ser Leu Gln
              20                  25                  30        
 Ser Ile Thr Pro Val Ala Phe Thr Ala Ser Gly Leu Val Gly Glu Ala
          35                  40                  45            
 Ser Tyr Trp Tyr Arg Ser Thr Leu Pro Ser Ala Val Ala Gly Arg Ser
      50                  55                  60                
 Gln Phe Asn Ala Arg Gln Thr Thr Phe Ile Asn Thr Glu Val Thr Arg
  65                  70                  75                  80
 Tyr Phe Ile Gln Glu His Ser His Trp His Gln Val Ser Ala Pro Leu
                  85                  90                  95    
 Gly Trp Ser Ser Gln Arg Lys Glu Gln Ala Ala Ile Phe Ala Val Leu
             100                 105                 110        
 Gln Pro Ala Leu Val Met Pro Pro Ala Arg Ala Gln Asn Trp Ala Glu
         115                 120                 125            
 Ala Glu Met Asp Glu Leu Thr Glu Val Gly Phe Arg Arg Trp Val Ile
     130                 135                 140                
 Thr Asn Phe Thr Glu Leu Lys Glu His Leu Leu Thr Gln Cys Lys Glu
 145                 150                 155                 160
 Ala Lys Asn Pro Asp Lys Thr Leu Asn Lys Leu Leu Thr Arg Ile Ser
                 165                 170                 175    
 Ser Leu Val Gly Thr
             180    



      <210> 1708
      <211> 531
      <212> PRT
      <213> Homo sapiens


      <400> 1708
 Met Gln Cys Gly Leu Gly Val Ser Val Leu Gly Met Ser Leu Leu Ser
   1               5                  10                  15    
 Pro Arg Cys Val Ser Val His Lys Leu His Lys Ser Ser Gln Val Ala
              20                  25                  30        
 Gly Val Ser Gly Asn Leu Ala Pro Gly Asn Gln Pro Glu Lys Glu Gly
          35                  40                  45            
 Arg Ala His Gln Cys Leu Glu Cys Asp Arg Ala Phe Ser Ser Ala Ala
      50                  55                  60                
 Val Leu Met His His Ser Lys Glu Val His Gly Arg Glu Arg Ile His
  65                  70                  75                  80
 Gly Cys Pro Val Cys Arg Lys Ala Phe Lys Arg Ala Thr His Leu Lys
                  85                  90                  95    
 Gly Lys Pro Asn Cys Thr Leu Arg Gly Val Gln Leu Val Gly Ile Ser
             100                 105                 110        
 Phe Lys Val Ile Ser Ile Glu Trp Gln Leu Arg Ala Leu Phe Pro Pro
         115                 120                 125            
 Gln Glu Ile Ser Leu Glu Val Arg Glu Thr Glu Ala Lys Val Ile Lys
     130                 135                 140                
 Ala Phe Leu Ser Ala His Trp Thr Val Cys Ser Pro Val Asp Ser Leu
 145                 150                 155                 160
 Ser Ser Phe Gln Leu Ser Lys His Leu Glu Ser Cys Phe Asp Leu Val
                 165                 170                 175    
 Ser Trp Phe Leu Cys Val Val Ser Gln Glu His Met Gln Thr His Gln
             180                 185                 190        
 Ala Gly Pro Ser Leu Ser Ser Gln Lys Pro Arg Val Phe Lys Cys Asp
         195                 200                 205            
 Thr Cys Glu Lys Ala Phe Ala Lys Pro Ser Gln Leu Glu Arg His Ser
     210                 215                 220                
 Arg Ile His Thr Gly Glu Arg Pro Phe His Cys Thr Leu Cys Glu Lys
 225                 230                 235                 240
 Ala Phe Asn Gln Lys Ser Ala Leu Gln Val His Met Lys Lys His Thr
                 245                 250                 255    
 Gly Glu Arg Pro Tyr Lys Cys Ala Tyr Cys Val Met Gly Phe Thr Gln
             260                 265                 270        
 Lys Ser Asn Met Lys Leu His Met Lys Arg Ala His Ser Tyr Ala Ala
         275                 280                 285            
 Cys Ser Ser Gly Ala Val Ser Val Leu Arg Gly Thr Glu Gln Thr Glu
     290                 295                 300                
 Ser Ala Pro Thr Ala Pro Val Cys Ile Leu Leu Thr Trp His Arg Gln
 305                 310                 315                 320
 His Val Gly Leu Gly Phe Ser Leu Asp Ser Leu Thr Phe Met Pro Phe
                 325                 330                 335    
 Arg Val Gln Gly Tyr Ile Ile Ala Glu Ala Gln Ala Ile His Arg Arg
             340                 345                 350        
 Arg His Ile Ala Leu Ile Asp Phe Glu Ile Glu Trp Val Arg Glu Ala
         355                 360                 365            
 Leu Trp Ile Pro Leu Arg Trp Ile Ile Ser Thr Ile Gly Ser Ala Phe
     370                 375                 380                
 Pro Ala Val Cys Leu His Gly Ser Asp Gln Gln Lys Arg Lys Gly Ala
 385                 390                 395                 400
 Ala Ala Thr Ala Lys Arg Lys Ser Lys Gly Gly Gly Val Asn Val Glu
                 405                 410                 415    
 Gly Arg Leu Cys Thr Trp Pro Pro Glu Asp Pro Pro Lys Ser Trp Ser
             420                 425                 430        
 Leu Ala Phe Gly Pro Leu Gln Glu Lys Thr Thr Glu Leu Asn Leu His
         435                 440                 445            
 Pro Arg Cys Trp Ala Arg Cys Leu Ser His Trp Glu Leu Pro Pro Gly
     450                 455                 460                
 Pro Arg Gly Arg Ala Gln Ala Pro Asp Trp Thr Gly Cys Lys Ala Cys
 465                 470                 475                 480
 Val Phe Arg Leu Ser Val Thr Trp Glu Pro Asn Leu Lys Arg Ser Glu
                 485                 490                 495    
 Leu Ser Gly Glu Arg Thr Glu Arg Thr Val Gln Ser Val Ala Asp Thr
             500                 505                 510        
 Val Gly Lys Arg Leu Pro Gly Thr Arg Asp Gln Lys Thr Val Leu Pro
         515                 520                 525            
 Pro Lys Ala
     530    



      <210> 1709
      <211> 202
      <212> PRT
      <213> Homo sapiens


      <400> 1709
 Met Ala Pro Leu Arg Ala Leu Leu Ser Tyr Leu Leu Pro Leu His Cys
   1               5                  10                  15    
 Ala Leu Cys Ala Ala Ala Gly Ser Arg Thr Pro Glu Leu His Leu Ser
              20                  25                  30        
 Gly Lys Leu Ser Asp Tyr Gly Val Thr Val Pro Cys Ser Thr Asp Phe
          35                  40                  45            
 Arg Gly Arg Phe Leu Ser His Val Val Ser Gly Pro Ala Ala Ala Ser
      50                  55                  60                
 Ala Gly Ser Met Val Val Asp Thr Pro Pro Thr Leu Pro Arg His Ser
  65                  70                  75                  80
 Ser His Leu Arg Val Ala Arg Ser Pro Leu His Pro Gly Gly Thr Leu
                  85                  90                  95    
 Trp Pro Gly Arg Val Gly Arg His Ser Leu Tyr Phe Asn Val Thr Val
             100                 105                 110        
 Phe Gly Lys Glu Leu His Leu Arg Leu Arg Pro Asn Arg Arg Leu Val
         115                 120                 125            
 Val Pro Gly Ser Ser Val Glu Trp Gln Glu Asp Phe Arg Glu Leu Phe
     130                 135                 140                
 Arg Gln Pro Leu Arg Gln Glu Cys Val Tyr Thr Gly Gly Val Thr Gly
 145                 150                 155                 160
 Met Pro Gly Ala Ala Val Ala Ile Ser Asn Cys Asp Gly Leu Cys Ala
                 165                 170                 175    
 Gly Pro Cys Glu Leu Ala Gln Gln Pro Gln Gly Pro Val Gly Gln Leu
             180                 185                 190        
 Phe Pro Ala Pro Glu Thr Ser Asp Val Ser
         195                 200        



      <210> 1710
      <211> 2978
      <212> PRT
      <213> Homo sapiens


      <400> 1710
 Met Asn Ile Ser Val Thr Leu Leu Ala Thr Val Leu Ala Ala Gly Phe
   1               5                  10                  15    
 Ser Gln Ala Asn Gln Phe Asn Tyr Gly Val Asp Asn Ala Glu Leu Gly
              20                  25                  30        
 Asn Ser Val Gln Leu Ile Ser Ser Phe Gln Ser Ile Thr Cys Asp Val
          35                  40                  45            
 Glu Lys Asp Ala Ser His Ser Thr Gln Ile Thr Cys Tyr Thr Arg Ala
      50                  55                  60                
 Met Pro Glu Asp Ser Tyr Thr Val Arg Val Ser Val Asp Gly Val Pro
  65                  70                  75                  80
 Val Thr Glu Asn Asn Thr Cys Lys Gly His Ile Asn Ser Trp Glu Cys
                  85                  90                  95    
 Thr Phe Asn Ala Lys Ser Phe Arg Thr Pro Thr Ile Arg Ser Ile Thr
             100                 105                 110        
 Pro Leu Ser Gly Thr Pro Gly Glu Pro Cys Asp Ile Leu Asn Val Thr
         115                 120                 125            
 Glu Asn Ser Ile Cys Cys Lys Thr Pro Pro Lys Pro His Ile Leu Lys
     130                 135                 140                
 Thr Val Tyr Pro Gly Gly Arg Gly Leu Lys Leu Glu Val Trp Asn Asn
 145                 150                 155                 160
 Ser Arg Pro Ile Arg Leu Glu Glu Ile Leu Glu Tyr Asn Glu Lys Thr
                 165                 170                 175    
 Pro Gly Tyr Met Gly Ala Ser Trp Val Asp Ser Ala Ser Tyr Ile Trp
             180                 185                 190        
 Leu Met Glu Gln Asp Thr Phe Val Ala Arg Phe Ser Gly Phe Leu Val
         195                 200                 205            
 Ala Pro Asp Ser Asp Val Tyr Arg Phe Tyr Ile Lys Gly Asp Asp Arg
     210                 215                 220                
 Tyr Ala Ile Tyr Phe Ser Gln Thr Gly Leu Pro Glu Asp Lys Val Arg
 225                 230                 235                 240
 Ile Ala Tyr His Ser Ala Asn Ala Asn Ser Tyr Phe Ser Ser Pro Thr
                 245                 250                 255    
 Gln Arg Ser Asp Asp Ile His Leu Gln Lys Gly Lys Glu Tyr Tyr Ile
             260                 265                 270        
 Glu Ile Leu Leu Gln Glu Tyr Arg Leu Ser Ala Phe Val Asp Val Gly
         275                 280                 285            
 Leu Tyr Gln Tyr Arg Asn Val Tyr Thr Glu Gln Gln Thr Gly Asp Ala
     290                 295                 300                
 Val Asn Glu Glu Gln Val Ile Lys Ser Gln Ser Thr Ile Leu Gln Glu
 305                 310                 315                 320
 Val Gln Val Ile Thr Leu Glu Asn Trp Glu Thr Thr Asn Ala Ile Asn
                 325                 330                 335    
 Glu Val Gln Lys Ile Lys Val Thr Ser Pro Cys Val Glu Ala Asn Ser
             340                 345                 350        
 Cys Ser Leu Tyr Gln Tyr Arg Leu Ile Tyr Asn Met Glu Lys Thr Gly
         355                 360                 365            
 Asp Phe Asp Leu Leu Gly Tyr Glu Val Val Glu Gly Asn Asn Val Thr
     370                 375                 380                
 Leu Asp Ile Thr Glu Gln Thr Lys Gly Lys Pro Asn Leu Glu Thr Phe
 385                 390                 395                 400
 Thr Leu Asn Trp Asp Gly Ile Ala Ser Lys Pro Leu Thr Leu Trp Ser
                 405                 410                 415    
 Ser Glu Ala Glu Gly Ala Val Glu Glu Met Val Ser Thr Lys Cys Pro
             420                 425                 430        
 Pro Gln Ile Ala Asn Phe Glu Glu Gly Phe Val Val Lys Tyr Phe Arg
         435                 440                 445            
 Asp Tyr Glu Thr Asp Phe Asn Leu Glu His Ile Asn Arg Gly Gln Lys
     450                 455                 460                
 Thr Ala Glu Thr Asp Ala Tyr Cys Gly Arg Tyr Ser Leu Lys Asn Pro
 465                 470                 475                 480
 Ala Val Leu Phe Asp Ser Ala Asp Val Lys Pro Asn Arg Arg Pro Tyr
                 485                 490                 495    
 Gly Asp Ile Leu Leu Phe Pro Tyr Asn Gln Arg Ile Ser Leu His Lys
             500                 505                 510        
 Ala Ser Glu Ser Gln Ser Phe Tyr Val Asp Val Val Tyr Ile Gly His
         515                 520                 525            
 Thr Ser Thr Ile Ser Thr Leu Asp Glu Met Pro Lys Arg Arg Leu Pro
     530                 535                 540                
 Ala Leu Ala Asn Lys Gly Ile Phe Leu Glu His Phe Gln Val Asn Gln
 545                 550                 555                 560
 Thr Lys Thr Asn Gly Pro Thr Met Thr Asn Gln Tyr Ser Val Thr Met
                 565                 570                 575    
 Thr Ser Tyr Asn Cys Ser Tyr Asn Ile Pro Met Met Ala Val Ser Phe
             580                 585                 590        
 Gly Gln Val Glu Val Tyr Val Asn Gly Ile Pro Ala Lys Cys Ser Gly
         595                 600                 605            
 Asp Cys Gly Phe Thr Trp Asp Ser Asn Ile Thr Pro Leu Val Leu Ala
     610                 615                 620                
 Ile Ser Pro Ser Gln Gly Ser Tyr Glu Glu Gly Thr Ile Leu Thr Ile
 625                 630                 635                 640
 Val Gly Ser Gly Phe Ser Pro Ser Ser Ala Val Thr Val Ser Val Gly
                 645                 650                 655    
 Pro Val Gly Cys Ser Leu Leu Ser Val Asp Glu Lys Glu Leu Lys Cys
             660                 665                 670        
 Gln Ile Leu Asn Gly Ser Ala Gly His Ala Pro Val Ala Val Ser Met
         675                 680                 685            
 Ala Asp Val Gly Leu Ala Gln Asn Val Gly Gly Glu Glu Phe Tyr Phe
     690                 695                 700                
 Val Tyr Gln Ser Gln Ile Ser His Ile Trp Pro Asp Ser Gly Ser Ile
 705                 710                 715                 720
 Ala Gly Gly Thr Leu Leu Thr Leu Ser Gly Phe Gly Phe Asn Glu Asn
                 725                 730                 735    
 Ser Lys Val Leu Val Gly Asn Glu Thr Cys Asn Val Ile Glu Gly Asp
             740                 745                 750        
 Leu Asn Arg Ile Thr Cys Arg Thr Pro Lys Lys Thr Glu Gly Thr Val
         755                 760                 765            
 Asp Ile Ser Val Thr Thr Asn Gly Phe Gln Ala Thr Ala Arg Asp Ala
     770                 775                 780                
 Phe Ser Tyr Asn Cys Leu Gln Thr Pro Ile Ile Thr Asp Phe Ser Pro
 785                 790                 795                 800
 Lys Val Arg Thr Ile Leu Gly Glu Val Asn Leu Thr Ile Lys Gly Tyr
                 805                 810                 815    
 Asn Phe Gly Asn Glu Leu Thr Gln Asn Met Ala Val Tyr Val Gly Gly
             820                 825                 830        
 Lys Thr Cys Gln Ile Leu His Trp Asn Phe Thr Asp Ile Arg Cys Leu
         835                 840                 845            
 Leu Pro Lys Leu Ser Pro Gly Lys His Asp Ile Tyr Val Glu Val Arg
     850                 855                 860                
 Asn Trp Gly Phe Ala Ser Thr Arg Asp Lys Leu Asn Ser Ser Ile Gln
 865                 870                 875                 880
 Tyr Val Leu Glu Val Thr Ser Met Phe Pro Gln Arg Gly Ser Leu Phe
                 885                 890                 895    
 Gly Gly Thr Glu Ile Thr Ile Arg Gly Phe Gly Phe Ser Thr Ile Pro
             900                 905                 910        
 Ala Glu Asn Thr Val Leu Leu Val His Gly Leu Gly Tyr Ala Trp Ser
         915                 920                 925            
 Pro Pro Val Leu Asn Val Ser Val Gly Asp Thr Val Ala Trp His Trp
     930                 935                 940                
 Gln Thr His Pro Phe Leu Arg Gly Ile Gly Tyr Arg Ile Phe Ser Val
 945                 950                 955                 960
 Ser Ser Pro Gly Ser Val Ile Tyr Asp Gly Lys Gly Phe Thr Ser Gly
                 965                 970                 975    
 Arg Gln Lys Ser Thr Ser Gly Val Ile Asn Val Leu Pro Ala Glu Thr
             980                 985                 990        
 Arg His Ile Pro Leu His Leu Phe Val Gly Arg Ser Glu Ala Thr Tyr
         995                1000                1005            
 Ala Tyr Gly Lys Met Val Lys Asp Gly Asn Ser Val Thr Gln Val Thr
    1010                1015                1020                
 Ile Gly Ser Tyr Pro Cys Val Val Glu Glu Ser Ser Glu Asp Ser Ile
1025                1030                1035                1040
 Thr Cys His Ile Asp Pro Gln Asn Ser Met Asp Val Gly Ile Arg Glu
                1045                1050                1055    
 Thr Val Thr Leu Thr Val Tyr Asn Leu Gly Thr Ala Ile Asn Thr Leu
            1060                1065                1070        
 Ser Asn Glu Phe Asp Arg Arg Phe Val Leu Leu Pro Asn Ile Asp Leu
        1075                1080                1085            
 Val Leu Pro Asn Ala Gly Ser Thr Thr Gly Met Thr Ser Val Thr Ile
    1090                1095                1100                
 Lys Gly Ser Gly Phe Ala Val Ser Ser Ala Gly Val Lys Val Leu Met
1105                1110                1115                1120
 Gly His Phe Pro Cys Lys Val Leu Ser Val Asn Tyr Thr Ala Ile Glu
                1125                1130                1135    
 Cys Glu Thr Ser Pro Ala Ala Gln Gln Leu Val Asp Val Asp Leu Leu
            1140                1145                1150        
 Ile His Gly Val Pro Ala Gln Cys Gln Gly Asn Cys Thr Phe Ser Tyr
        1155                1160                1165            
 Leu Glu Ser Ile Thr Pro Tyr Ile Thr Gly Val Phe Pro Asn Ser Val
    1170                1175                1180                
 Ile Gly Ser Val Lys Val Leu Ile Glu Gly Glu Gly Leu Gly Thr Val
1185                1190                1195                1200
 Leu Glu Asp Ile Ala Val Phe Ile Gly Asn Gln Gln Phe Arg Ala Ile
                1205                1210                1215    
 Glu Val Asn Glu Asn Asn Ile Thr Ala Leu Val Thr Pro Leu Pro Val
            1220                1225                1230        
 Gly His His Ser Val Ser Val Val Val Gly Ser Lys Gly Leu Ala Leu
        1235                1240                1245            
 Gly Asn Leu Thr Val Ser Ser Pro Pro Val Ala Ser Leu Ser Pro Thr
    1250                1255                1260                
 Ser Gly Ser Ile Gly Gly Gly Thr Thr Leu Val Ile Thr Gly Asn Gly
1265                1270                1275                1280
 Phe Tyr Pro Gly Asn Thr Thr Val Thr Ile Gly Asp Glu Pro Cys Gln
                1285                1290                1295    
 Ile Ile Ser Ile Asn Pro Asn Glu Val Tyr Cys Arg Thr Pro Ala Gly
            1300                1305                1310        
 Thr Thr Gly Met Val Asp Val Lys Ile Phe Val Asn Thr Ile Ala Tyr
        1315                1320                1325            
 Pro Pro Leu Leu Phe Thr Tyr Ala Leu Glu Asp Thr Pro Phe Leu Arg
    1330                1335                1340                
 Gly Ile Ile Pro Ser Arg Gly Pro Pro Gly Thr Glu Ile Glu Ile Thr
1345                1350                1355                1360
 Gly Ser Asn Phe Gly Phe Glu Ile Leu Glu Ile Ser Val Met Ile Asn
                1365                1370                1375    
 Asn Ile Gln Cys Asn Val Thr Met Ala Asn Asp Ser Val Val Gln Cys
            1380                1385                1390        
 Ile Val Gly Asp His Ala Gly Gly Thr Phe Pro Val Met Met His His
        1395                1400                1405            
 Lys Thr Lys Gly Ser Ala Met Ser Thr Val Val Phe Glu Tyr Pro Leu
    1410                1415                1420                
 Asn Ile Gln Asn Ile Asn Pro Ser Gln Gly Ser Phe Gly Gly Gly Gln
1425                1430                1435                1440
 Thr Met Thr Val Thr Gly Thr Gly Phe Asn Pro Gln Asn Ser Ile Ile
                1445                1450                1455    
 Leu Val Cys Gly Ser Glu Cys Ala Ile Asp Arg Leu Arg Ser Asp Tyr
            1460                1465                1470        
 Thr Thr Leu Leu Cys Glu Ile Pro Ser Asn Asn Gly Thr Gly Ala Glu
        1475                1480                1485            
 Gln Ala Cys Glu Val Ser Val Val Asn Gly Lys Asp Leu Ser Gln Ser
    1490                1495                1500                
 Met Thr Pro Phe Thr Tyr Ala Val Ser Leu Thr Pro Leu Ile Thr Ala
1505                1510                1515                1520
 Val Ser Pro Lys Arg Gly Ser Thr Ala Gly Gly Thr Arg Leu Thr Val
                1525                1530                1535    
 Val Gly Ser Gly Phe Ser Glu Asn Met Glu Asp Val His Ile Thr Ile
            1540                1545                1550        
 Ala Glu Ala Lys Cys Asp Val Glu Tyr Ser Asn Lys Thr His Ile Ile
        1555                1560                1565            
 Cys Met Thr Asp Ala His Thr Leu Ser Gly Trp Ala Pro Val Cys Val
    1570                1575                1580                
 His Ile Arg Gly Val Gly Met Ala Lys Leu Asp Asn Ala Asp Phe Leu
1585                1590                1595                1600
 Tyr Val Asp Ala Trp Ser Ser Asn Phe Ser Trp Gly Gly Lys Ser Pro
                1605                1610                1615    
 Pro Glu Glu Gly Ser Leu Val Val Ile Thr Lys Gly Gln Thr Ile Leu
            1620                1625                1630        
 Leu Asp Gln Ser Thr Pro Ile Leu Lys Met Leu Leu Ile Gln Gly Val
        1635                1640                1645            
 Pro Val Pro Val Thr Trp Thr Arg Leu Ala His Thr Ala Lys Ala Gly
    1650                1655                1660                
 Glu Arg Ile Leu Ile Leu Gln Glu Ala Val Thr Trp Lys Pro Gly Asp
1665                1670                1675                1680
 Asn Ile Val Ile Ala Ser Thr Gly His Arg His Ser Gln Gly Glu Asn
                1685                1690                1695    
 Glu Lys Met Thr Ile Ala Ser Val Ser Ala Asp Gly Ile Asn Ile Thr
            1700                1705                1710        
 Leu Ser Asn Pro Leu Asn Tyr Thr His Leu Gly Ile Thr Val Thr Leu
        1715                1720                1725            
 Pro Asp Gly Thr Leu Phe Glu Ala Arg Ala Glu Val Gly Ile Leu Thr
    1730                1735                1740                
 Arg Asn Ile Leu Ile Arg Gly Ser Asp Asn Val Glu Trp Asn Asn Lys
1745                1750                1755                1760
 Ile Pro Ala Cys Pro Asp Gly Phe Asp Thr Gly Glu Phe Ala Thr Gln
                1765                1770                1775    
 Thr Cys Leu Gln Gly Lys Phe Gly Glu Glu Ile Gly Ser Asp Gln Phe
            1780                1785                1790        
 Gly Gly Cys Val Met Phe His Ala Pro Val Pro Gly Ala Asn Met Val
        1795                1800                1805            
 Thr Gly Arg Ile Glu Tyr Val Glu Val Phe His Ala Gly Gln Ala Phe
    1810                1815                1820                
 Arg Leu Gly Arg Tyr Pro Ile His Trp His Leu Leu Gly Asp Leu Gln
1825                1830                1835                1840
 Phe Lys Ser Tyr Val Arg Gly Cys Ala Ile His Gln Ala Tyr Asn Arg
                1845                1850                1855    
 Ala Val Thr Ile His Asn Thr His His Leu Leu Val Glu Arg Asn Ile
            1860                1865                1870        
 Ile Tyr Asp Ile Lys Gly Gly Ala Phe Phe Ile Glu Asp Gly Ile Glu
        1875                1880                1885            
 His Gly Asn Ile Leu Gln Tyr Asn Leu Ala Val Phe Val Gln Gln Ser
    1890                1895                1900                
 Thr Ser Leu Leu Asn Asp Asp Val Thr Pro Ala Ala Phe Trp Val Thr
1905                1910                1915                1920
 Asn Pro Asn Asn Thr Ile Arg His Asn Ala Val Ala Gly Gly Thr His
                1925                1930                1935    
 Phe Gly Phe Trp Tyr Arg Met Asn Asn His Pro Asp Gly Pro Ser Tyr
            1940                1945                1950        
 Asp Arg Asn Ile Cys Gln Lys Arg Val Pro Leu Gly Glu Phe Phe Asn
        1955                1960                1965            
 Asn Thr Val His Ser Gln Gly Trp Phe Gly Met Trp Ile Phe Glu Glu
    1970                1975                1980                
 Tyr Phe Pro Met Gln Thr Gly Ser Cys Thr Ser Thr Val Pro Ala Pro
1985                1990                1995                2000
 Ala Ile Phe Asn Ser Leu Thr Thr Trp Asn Cys Gln Lys Gly Ala Glu
                2005                2010                2015    
 Trp Val Asn Gly Gly Ala Leu Gln Phe His Asn Phe Val Met Val Asn
            2020                2025                2030        
 Asn Tyr Glu Ala Gly Ile Glu Thr Lys Arg Ile Leu Ala Pro Tyr Val
        2035                2040                2045            
 Gly Gly Trp Gly Glu Thr Asn Gly Ala Val Ile Lys Asn Ala Lys Ile
    2050                2055                2060                
 Val Gly His Leu Asp Glu Leu Gly Met Gly Ser Ala Phe Cys Thr Ala
2065                2070                2075                2080
 Lys Gly Leu Val Leu Pro Phe Ser Glu Gly Leu Thr Val Ser Ser Val
                2085                2090                2095    
 His Phe Met Asn Phe Asp Arg Pro Asn Cys Val Ala Leu Gly Val Thr
            2100                2105                2110        
 Ser Ile Ser Gly Val Cys Asn Asp Arg Cys Gly Gly Trp Ser Ala Lys
        2115                2120                2125            
 Phe Val Asp Val Gln Tyr Ser His Thr Pro Asn Lys Ala Gly Phe Arg
    2130                2135                2140                
 Trp Glu His Glu Met Val Met Ile Asp Val Asp Gly Ser Leu Thr Gly
2145                2150                2155                2160
 His Lys Gly His Thr Val Ile Pro His Ser Ser Leu Leu Asp Pro Ser
                2165                2170                2175    
 His Cys Thr Gln Glu Ala Glu Trp Ser Ile Gly Phe Pro Gly Ser Val
            2180                2185                2190        
 Cys Asp Ala Ser Val Ser Phe His Arg Leu Ala Phe Asn Gln Pro Ser
        2195                2200                2205            
 Pro Val Ser Leu Leu Glu Lys Asp Val Val Leu Ser Asp Ser Phe Val
    2210                2215                2220                
 Asp Pro Gln Lys Tyr Leu Asp Glu Asp Trp Glu Lys Tyr Leu Glu Asp
2225                2230                2235                2240
 Pro Ala Phe Asp Thr Ser Tyr Ser Thr Glu Pro Cys Trp Lys Tyr Ser
                2245                2250                2255    
 Asp His His Glu Asn Lys Tyr Cys Asp Leu Glu Cys Ser His Thr Cys
            2260                2265                2270        
 Asn Cys Lys Thr Arg Ser Ser Ser Tyr Leu Asp Asn Leu Val Trp Arg
        2275                2280                2285            
 Glu Ser Glu Val Asn His Tyr Tyr Glu Pro Lys Leu Ile Ile Asp Leu
    2290                2295                2300                
 Ser Asn Trp Arg Glu Gln Ser Lys Glu Lys Thr Asp Lys Lys Gly Lys
2305                2310                2315                2320
 Ser Lys Cys Glu Arg Asn Gly Leu Val Lys Ala Gln Ile Ala Leu Glu
                2325                2330                2335    
 Glu Ala Ser Gln Gln Leu Ala Gly Lys Glu Arg Glu Lys Lys Gln Gly
            2340                2345                2350        
 Phe Asp Phe Asp Ser Phe Ile Ala Gly Thr Ile Gln Leu Ser Ser Gln
        2355                2360                2365            
 His Glu Pro Thr Asp Val Val Asp Lys Leu Asn Asp Leu Asn Ser Ser
    2370                2375                2380                
 Val Ser Gln Leu Glu Leu Lys Ser Leu Ile Ser Asn Leu Trp Ser Asn
2385                2390                2395                2400
 Asp Ser Phe Trp Gln Ser Ser Arg Glu Asn Asn Tyr Thr Val Pro His
                2405                2410                2415    
 Pro Gly Ala Asn Val Ile Ile Pro Glu Gly Thr Trp Ile Val Ala Asp
            2420                2425                2430        
 Ile Asp Met Pro Ser Met Glu Arg Leu Ile Ile Trp Gly Val Leu Glu
        2435                2440                2445            
 Leu Glu Asp Lys Tyr Asn Val Gly Ala Ala Glu Ser Ser Tyr Arg Glu
    2450                2455                2460                
 Val Val Leu Asn Ala Thr Tyr Ile Ser Leu Gln Gly Gly Arg Leu Ile
2465                2470                2475                2480
 Gly Gly Trp Glu Asp Asn Pro Phe Lys Gly Asp Leu Lys Ile Val Leu
                2485                2490                2495    
 Arg Gly Asn His Thr Thr Gln Asp Trp Ala Leu Pro Glu Gly Pro Asn
            2500                2505                2510        
 Gln Gly Ala Lys Val Leu Gly Val Phe Gly Glu Leu Asp Leu His Gly
        2515                2520                2525            
 Ile Pro His Ser Ile Tyr Lys Thr Lys Leu Ser Glu Thr Ala Phe Ala
    2530                2535                2540                
 Gly Ser Lys Val Leu Ser Leu Met Asp Ala Val Asp Trp Gln Ile Asn
2545                2550                2555                2560
 Arg Gly Thr Asn Thr Val Leu Gln Asn Asn Val Val Ala Gly Phe Gly
                2565                2570                2575    
 Arg Ala Gly Tyr Arg Ile Asp Gly Glu Pro Cys Pro Gly Gln Phe Asn
            2580                2585                2590        
 Pro Val Glu Lys Trp Phe Asp Asn Glu Ala His Gly Gly Leu Tyr Gly
        2595                2600                2605            
 Ile Tyr Met Asn Gln Asp Gly Leu Pro Gly Cys Ser Leu Ile Gln Gly
    2610                2615                2620                
 Phe Thr Ile Trp Thr Cys Trp Asp Tyr Gly Ile Tyr Phe Gln Thr Thr
2625                2630                2635                2640
 Glu Ser Val His Ile Tyr Asn Val Thr Leu Val Asp Asn Gly Met Ala
                2645                2650                2655    
 Ile Phe Pro Met Ile Tyr Met Pro Ala Ala Ile Ser His Lys Ile Ser
            2660                2665                2670        
 Ser Lys Asn Val Gln Ile Lys Ser Ser Leu Ile Val Gly Ser Ser Pro
        2675                2680                2685            
 Gly Phe Asn Cys Ser Asp Val Leu Thr Asn Asp Asp Pro Asn Ile Glu
    2690                2695                2700                
 Leu Thr Ala Ala His Arg Ser Pro Arg Ser Pro Ser Gly Ser Thr Phe
2705                2710                2715                2720
 Val Gly Phe Lys Asn Val Cys Ser Gly Glu Thr Asn Val Ile Phe Ile
                2725                2730                2735    
 Thr Asn Pro Leu Asn Glu Asp Leu Gln His Pro Ile His Val Lys Asn
            2740                2745                2750        
 Ile Lys Leu Val Asp Thr Thr Glu Gln Ser Lys Ile Phe Ile His Arg
        2755                2760                2765            
 Pro Asp Ile Ser Lys Val Asn Pro Ser Asp Cys Val Asp Met Val Cys
    2770                2775                2780                
 Asp Ala Lys Arg Lys Ser Phe Leu Arg Asp Ile Asp Gly Ser Phe Leu
2785                2790                2795                2800
 Gly Asn Ala Gly Ser Val Ile Pro Gln Ala Glu Tyr Glu Trp Asp Gly
                2805                2810                2815    
 Asn Ser Gln Val Gly Ile Gly Asp Tyr Arg Ile Pro Lys Ala Met Leu
            2820                2825                2830        
 Thr Phe Leu Asn Gly Ser Arg Ile Pro Val Thr Glu Lys Ala Pro His
        2835                2840                2845            
 Lys Gly Ile Ile Arg Asp Ser Thr Cys Lys Tyr Leu Pro Glu Trp Gln
    2850                2855                2860                
 Ser Tyr Gln Cys Phe Gly Met Glu Tyr Ala Met Met Val Ile Glu Ser
2865                2870                2875                2880
 Leu Asp Pro Asp Thr Glu Thr Arg Arg Leu Ser Pro Val Ala Ile Met
                2885                2890                2895    
 Gly Asn Gly Tyr Val Asp Leu Ile Asn Gly Pro Gln Asp His Gly Trp
            2900                2905                2910        
 Cys Ala Gly Tyr Thr Cys Gln Arg Arg Leu Ser Leu Phe His Ser Ile
        2915                2920                2925            
 Val Ala Leu Asn Lys Ser Tyr Glu Val Tyr Phe Thr Gly Thr Ser Pro
    2930                2935                2940                
 Gln Asn Leu Arg Leu Met Leu Leu Asn Val Asp His Asn Lys Val Gly
2945                2950                2955                2960
 Gln Asp Val Leu Arg Val Ile Ala Val Asp Tyr Leu His Val Ile Ser
                2965                2970                2975    
 Ile Cys
        



      <210> 1711
      <211> 400
      <212> PRT
      <213> Homo sapiens


      <400> 1711
 Met Trp Cys Lys Pro Leu Pro Pro Ile Pro Trp Leu Ala Leu Gly Ala
   1               5                  10                  15    
 Ser Pro Ala Met Val Ile Glu Thr Glu Glu Ala Ser Gln Phe Ala Ala
              20                  25                  30        
 Ile Ala Ser Ala Leu Leu Ile Lys Arg Trp His Thr Asp Ala Ala Thr
          35                  40                  45            
 Gln Leu Thr Ala Asp Ala Val Ala Ala Arg Met Trp Ala Ile His Leu
      50                  55                  60                
 Arg Arg Arg Ala Ser His Gly Tyr Ala Glu Arg Cys Ala His Gly Ser
  65                  70                  75                  80
 Ser Val Phe Thr Glu Arg Arg Trp Thr Ser Gly Ile Ile Pro Cys Leu
                  85                  90                  95    
 Ser Gln Arg Leu Thr Ala Asp Ile Ser Pro Tyr Ser Leu Gln Leu Arg
             100                 105                 110        
 Gly Thr Ile Asn Phe Phe Met Asp Asp Gln Thr Gln Ile Gly Trp Arg
         115                 120                 125            
 Gly Tyr Arg Thr Ala Asp Ser Lys Thr Val Thr Glu Ala Pro Gly Arg
     130                 135                 140                
 Asn Ile Trp Gly Leu Ala Met Glu Leu Ala Leu Ala Ala Ala Asn Pro
 145                 150                 155                 160
 Cys His Ala Ser Pro Ser His Met Leu Gly Leu His Gly Phe Val Ala
                 165                 170                 175    
 Ala Glu Val Leu Cys Ala His Leu Ser Ala Arg Ser Pro Ala Pro Ser
             180                 185                 190        
 Ala Ser Thr Ala Ser Ile His Ser Ile Ser Leu Thr Gly Ser Leu Lys
         195                 200                 205            
 Glu Ala Thr Arg Gly Ser Pro Ala Thr Arg Gln Leu Asp Thr Val Glu
     210                 215                 220                
 Leu Val Met Ala Leu Glu Glu Glu Phe Asp Thr Glu Ile Pro Asp Glu
 225                 230                 235                 240
 Glu Ala Glu Lys Ile Thr Thr Val Gln Ala Ala Ile Asp Tyr Ile Asn
                 245                 250                 255    
 Gly His Gln Ala Thr Asn Val Ser Lys Arg Arg Val Val Val Thr Gly
             260                 265                 270        
 Leu Gly Met Leu Ser Pro Val Gly Asn Thr Val Glu Ser Thr Trp Lys
         275                 280                 285            
 Ala Leu Leu Ala Gly Gln Ser Gly Ile Ser Leu Ile Asp His Phe Asp
     290                 295                 300                
 Thr Ser Ala Tyr Ala Thr Lys Phe Ala Gly Leu Val Lys Asp Phe Asn
 305                 310                 315                 320
 Cys Glu Asp Asn Ala Gly Thr Lys Gln Gln Val Glu Leu Val Arg Gly
                 325                 330                 335    
 Gly His Gly His Trp Arg Asp Val Ser Ala Lys Gln Lys Cys Leu Ser
             340                 345                 350        
 Val Thr Gln Lys Asp Val Ala Val Ala Asp Ile Gly Phe Ser Cys Ala
         355                 360                 365            
 Gln Gly Phe Asn Phe Pro Ala Leu Gln Gly Lys Ser Arg Phe Glu Leu
     370                 375                 380                
 Phe Phe Asp Lys Val Phe Val Thr Arg Lys Phe Gln Lys Glu Val Pro
 385                 390                 395                 400





      <210> 1712
      <211> 464
      <212> PRT
      <213> Homo sapiens


      <400> 1712
 Met Gln Arg Ala Arg Pro Thr Leu Trp Ala Ala Ala Leu Thr Leu Leu
   1               5                  10                  15    
 Val Leu Leu Arg Gly Pro Pro Val Ala Arg Ala Gly Ala Ser Ser Ala
              20                  25                  30        
 Gly Leu Gly Pro Val Val Arg Cys Glu Pro Cys Asp Ala Arg Ala Leu
          35                  40                  45            
 Ala Gln Cys Ala Pro Pro Pro Ala Val Cys Ala Glu Leu Val Arg Glu
      50                  55                  60                
 Pro Gly Cys Gly Cys Cys Leu Thr Cys Ala Leu Ser Glu Gly Gln Pro
  65                  70                  75                  80
 Cys Gly Ile Tyr Thr Glu Arg Cys Gly Ser Gly Leu Arg Cys Gln Pro
                  85                  90                  95    
 Ser Pro Asp Glu Ala Arg Pro Leu Gln Ala Leu Leu Asp Gly Arg Gly
             100                 105                 110        
 Leu Cys Val Asn Ala Ser Ala Val Ser Arg Leu Arg Ala Tyr Leu Leu
         115                 120                 125            
 Pro Ala Pro Pro Ala Pro Ala Cys Leu Pro Gly Ser Ile Glu Asp Gly
     130                 135                 140                
 Thr Gly Gln Pro Trp Asn Ser His Lys Gly Leu Leu Gln Leu Arg Leu
 145                 150                 155                 160
 Leu Pro Pro Leu Gln Arg Phe Arg Ser Gly Glu Cys Ala Phe Leu Pro
                 165                 170                 175    
 Ser Pro Arg Ala Ala Ala Ala Pro Ala Gly Asn Ala Ser Glu Ser Glu
             180                 185                 190        
 Glu Asp Arg Ser Ala Gly Ser Val Glu Ser Pro Ser Val Ser Ser Thr
         195                 200                 205            
 His Arg Val Ser Asp Pro Lys Phe His Pro Leu His Ser Lys Ile Ile
     210                 215                 220                
 Ile Ile Lys Lys Gly His Ala Lys Asp Ser Gln Arg Tyr Lys Val Asp
 225                 230                 235                 240
 Tyr Glu Ser Gln Ser Thr Asp Thr Gln Asn Phe Ser Ser Glu Ser Lys
                 245                 250                 255    
 Arg Glu Thr Glu Tyr Gly Pro Cys Arg Arg Glu Met Glu Asp Thr Leu
             260                 265                 270        
 Asn His Leu Lys Phe Leu Asn Val Leu Ser Pro Arg Gly Val His Ile
         275                 280                 285            
 Pro Asn Cys Asp Lys Lys Gly Phe Tyr Lys Lys Lys Gln His Ile Pro
     290                 295                 300                
 Gly Val Cys Leu Gly Val Glu Gly Met Glu Leu Glu Ile Arg His Ser
 305                 310                 315                 320
 Val His Ala Gly Asp Gly Gln Ser Leu Gln Thr Gly His Val Val Phe
                 325                 330                 335    
 Leu Arg Leu Thr Gly Ile Ser Leu Glu Ser Pro Thr Lys Glu Pro Lys
             340                 345                 350        
 Ser Val Ser Met Ala Leu Trp Glu Ala Tyr Gly Gly Ile Gly Ser Tyr
         355                 360                 365            
 Leu Gln Asp Gly Pro Ile Leu Gly Gly Cys Val Val Gly Thr Val Cys
     370                 375                 380                
 Gly Pro Gly His Met Tyr Pro Ser Asn Leu His Ala Asp Thr His Arg
 385                 390                 395                 400
 Asn Glu Gln Val Arg Val Val Ser Ser Met Gly Val Lys Val Met Gln
                 405                 410                 415    
 Val Leu Gln Gln Gln Leu Pro Lys Ile Lys Leu Ser Asn Gln His Thr
             420                 425                 430        
 Leu Gly Lys Ile Lys Ile Thr Ile Val Asp Glu Gly Thr Leu Met Gly
         435                 440                 445            
 Phe Gln Val Leu Cys Cys Gly Ser Leu Ser Arg Gly Thr Phe Leu Ile
     450                 455                 460                





      <210> 1713
      <211> 206
      <212> PRT
      <213> Homo sapiens


      <400> 1713
 Met Ser Cys Tyr Gln Arg His Ser Gln Lys Phe His Gly Val Phe Val
   1               5                  10                  15    
 Val Cys Phe Ala Leu Leu Thr Phe Ile Gln Gly Val Thr Arg Leu Ala
              20                  25                  30        
 Asp Ile Ser Leu His Asp Pro Val Ser Ile Ser Val Leu Asp Lys Ser
          35                  40                  45            
 His Asp Gln Leu Asn Pro Lys Asp Lys Ala Val Gln Glu Val Cys Pro
      50                  55                  60                
 Pro Pro Ala Gly Asp Lys Leu Asp Ser Phe Ala Ile Pro Glu Ser Leu
  65                  70                  75                  80
 Lys Gln His Val Thr Val Val Pro Ser Lys Leu Arg Leu Val Cys Leu
                  85                  90                  95    
 Ala Ala Phe Ile Leu Gln Lys Cys Lys Phe Glu Glu Asp Gln Lys Met
             100                 105                 110        
 Val Val Phe Phe Ser Ser Cys Glu Leu Val Glu Phe His Tyr Ser Leu
         115                 120                 125            
 Phe Leu Gln Thr Leu Leu Ser Ser Ser Gly Ala Pro Ala Ser Gly Gln
     130                 135                 140                
 Leu Pro Ser Ala Ser Met Arg Leu Lys Phe Leu Arg Leu His Gly Gly
 145                 150                 155                 160
 Met Glu Gln Glu Gly Leu Gly Tyr Val Ser Arg Ile Pro Pro Leu Leu
                 165                 170                 175    
 Thr Arg Pro Phe Val Met Glu Ser Gly Trp Asn Met Gly Val Arg Tyr
             180                 185                 190        
 Thr His Trp Asn Trp Glu Arg Lys Asn Glu Gln Asp Ser Lys
         195                 200                 205    



      <210> 1714
      <211> 439
      <212> PRT
      <213> Homo sapiens


      <400> 1714
 Met Thr Leu Glu Val Pro Val Phe Ser Leu Leu Trp Val Val Ile Met
   1               5                  10                  15    
 Met Val Thr Gly Leu Pro Asp Ala Arg Val Lys Glu Leu Leu Leu Ser
              20                  25                  30        
 Lys Gly Pro Gly Thr His Met Pro Glu Lys His Gly Lys Arg Gln Arg
          35                  40                  45            
 Asp Ala Arg Glu Asn Ala Thr Thr Val Pro Val Arg Asn Gln Gln Cys
      50                  55                  60                
 Arg Val Ala Ile Tyr Pro Gln His Met Gln Asp Ala Ala Leu Asp Ala
  65                  70                  75                  80
 Asp Ser Val Ser Gln Pro Tyr Arg Arg Lys Val Ser Ala Phe Leu Lys
                  85                  90                  95    
 Leu His Asp His Pro Ser Val Gly Tyr Pro Lys Pro Arg Phe Ala Ala
             100                 105                 110        
 Ala Gly Leu Glu Gln Glu Ile Gln Thr Leu Glu Ser Glu Glu Ser Gln
         115                 120                 125            
 Ile Ser Ala Lys Glu Gln Ile Ile Leu Glu Lys Leu Lys Glu Thr Glu
     130                 135                 140                
 Lys Ser Phe Lys Asp Phe Gln Lys Gly Phe Ser Ser Thr Asp Gly Asp
 145                 150                 155                 160
 Ala Val Asn Tyr Ile Ser Ser Gln Leu Pro Asp Leu Pro Ile Leu Cys
                 165                 170                 175    
 Ser Arg Thr Ala Glu Pro Ser Pro Gly Gln Asp Gly Thr Ser Arg Ala
             180                 185                 190        
 Ala Ala Val Tyr Ala Met Glu Ile Asn Val Glu Lys Asp Lys Gln Thr
         195                 200                 205            
 Gly Glu Thr Lys Ile Leu Ser Thr Ser Thr Ile Gly Pro Glu Gly Val
     210                 215                 220                
 His Gln Lys Gly Val Lys Val Tyr Asp Asp Gly Thr Lys Val Val Tyr
 225                 230                 235                 240
 Glu Val Arg Ser Gly Gly Thr Val Val Glu Asn Gly Val His Lys Leu
                 245                 250                 255    
 Ser Thr Lys Asp Val Glu Glu Leu Ile Gln Lys Ala Gly Gln Ser Ser
             260                 265                 270        
 Leu Gly Gly Gly His Val Ser Glu Arg Thr Val Ile Ala Asp Gly Ser
         275                 280                 285            
 Leu Ser His Pro Lys Glu His Met Leu Cys Lys Glu Ala Lys Leu Glu
     290                 295                 300                
 Met Val His Lys Ser Arg Lys Asp His Ser Ser Gly Asn Pro Gly Gln
 305                 310                 315                 320
 Gln Ala Gln Ala Pro Ser Ala Ala Gly Pro Glu Ala Asn Leu Asp Gln
                 325                 330                 335    
 Pro Val Thr Met Ile Phe Met Gly Tyr Gln Asn Ile Glu Asp Glu Glu
             340                 345                 350        
 Glu Thr Lys Lys Val Leu Gly Tyr Asp Glu Thr Ile Lys Ala Glu Leu
         355                 360                 365            
 Val Leu Ile Asp Glu Asp Asp Glu Lys Ser Leu Arg Glu Lys Thr Val
     370                 375                 380                
 Thr Asp Val Ser Thr Ile Asp Gly Asn Ala Ala Glu Leu Val Ser Gly
 385                 390                 395                 400
 Arg Pro Val Ser Asp Thr Thr Glu Pro Ser Ser Pro Glu Gly Lys Glu
                 405                 410                 415    
 Glu Ser Leu Ala Thr Glu Pro Ala Pro Gly Thr Gln Lys Lys Lys Arg
             420                 425                 430        
 Cys Gln Cys Cys Val Val Met
         435                



      <210> 1715
      <211> 226
      <212> PRT
      <213> Homo sapiens


      <400> 1715
 Met Gly Thr Leu Gln Gln Gly Leu Ala Ser Ala Ala Ala Ile Leu Met
   1               5                  10                  15    
 Asp Trp Pro Leu Leu Val Ile Asp Leu Lys Asp Tyr Phe Phe Thr Ile
              20                  25                  30        
 Pro Phe His Glu Lys Asp Glu Pro Arg Phe Ala Phe Ser Val Leu Ser
          35                  40                  45            
 Ile His Gln Arg Gln Pro Gly Ser His Tyr Gln Trp Lys Val Leu Pro
      50                  55                  60                
 Gln Gly Met Leu Asn Ser Pro Val Leu Cys Gln His Phe Val Gly Gln
  65                  70                  75                  80
 Ala Leu Lys Glu Pro Arg Asn Met Phe Pro Thr Ala Tyr Ile Val His
                  85                  90                  95    
 Tyr Met Glu Asp Ile Leu Leu Ala Thr Pro Thr Asp Gln Ile Leu His
             100                 105                 110        
 Gln Leu Phe Arg Glu Thr Lys Gln Ala Leu Ile Lys Trp Asn Leu Lys
         115                 120                 125            
 Ile Ala Pro Glu Lys Val Gln Thr Thr Ser Pro His Arg Tyr Leu Ser
     130                 135                 140                
 Thr Ile Val Thr Glu Arg Ser Val Arg Leu Gln Lys Val Thr Leu Arg
 145                 150                 155                 160
 Arg Asp Arg Leu Gln Thr Leu Lys Asp Phe Gln Gln Leu Leu Gly Asp
                 165                 170                 175    
 Ile Asn Trp Leu His Leu Met Ile Gly Ile Ala Thr Tyr Arg Leu Lys
             180                 185                 190        
 His Leu Tyr Gln Thr Leu Gln Gly Asp Ser Ser Leu Asp Ser Pro Trp
         195                 200                 205            
 Gln Leu Thr Lys Glu Ala Glu Ala Glu Leu Gln Leu Val Glu Gln Met
     210                 215                 220                
 Leu Gln
 225    



      <210> 1716
      <211> 107
      <212> PRT
      <213> Homo sapiens


      <400> 1716
 Met Ala Ala Lys Cys Leu Asp Val Leu Gln Ala Leu Ile Phe Arg Ala
   1               5                  10                  15    
 Leu Ala Ala Phe Pro Arg Gly Arg Ala Arg Asp Leu Gln Pro Ala Met
              20                  25                  30        
 Pro Glu Pro Pro Thr His Ser Met Gly Ser Cys Ala Ala Arg Ala Ser
          35                  40                  45            
 Pro Thr Ser Thr Thr Pro Cys Ser Thr Val Pro Ser Pro Ile Asp His
      50                  55                  60                
 Pro Arg Ala Glu Glu Cys Glu Arg Lys Val Arg Asp Trp Gln Ala Ala
  65                  70                  75                  80
 Ser Pro Ala Ala Pro Val Arg Asp Pro Leu Gly Glu Ala Ser Trp Ala
                  85                  90                  95    
 Pro Glu Ser Glu Gly Lys Asn Ser Glu His Ile
             100                 105        



      <210> 1717
      <211> 1543
      <212> PRT
      <213> Homo sapiens


      <400> 1717
 Met Asn Leu Gln Cys Met Ser Tyr Tyr His Gly Asn Met Ser Leu Thr
   1               5                  10                  15    
 Phe Phe Val Ser Ile Leu Cys His Leu Leu Val Arg Ile Leu Lys Glu
              20                  25                  30        
 Met Glu Lys Asp Met Pro Gln Tyr Leu Ser Glu Phe Ser Leu Glu Lys
          35                  40                  45            
 Asn Glu Ala Thr Thr Glu Ser Asn Asp Pro Phe Arg Glu Ser Val Leu
      50                  55                  60                
 Asn Ser Glu Leu Tyr Ser Glu Ala Leu Gly Gln Tyr Met Val Leu Val
  65                  70                  75                  80
 Pro Ser Leu Leu His Thr Glu Ala Pro Lys Lys Gly Cys Val Leu Leu
                  85                  90                  95    
 Ser His Leu Asn Glu Thr Val Thr Val Ser Ala Ser Leu Glu Ser Gly
             100                 105                 110        
 Arg Glu Asn Arg Ser Leu Phe Thr Asp Leu Val Ala Glu Lys Asp Leu
         115                 120                 125            
 Phe His Cys Val Ser Phe Thr Leu Pro Arg Ile Ser Ala Ser Ser Glu
     130                 135                 140                
 Val Ala Phe Leu Ser Ile Gln Ile Lys Gly Pro Thr Gln Asp Phe Arg
 145                 150                 155                 160
 Lys Arg Asn Thr Val Leu Val Leu Asn Thr Gln Ser Leu Val Phe Val
                 165                 170                 175    
 Gln Thr Asp Lys Pro Met Tyr Lys Pro Gly Gln Thr Val Arg Phe Arg
             180                 185                 190        
 Val Val Ser Val Asp Glu Asn Phe Arg Pro Arg Asn Glu Leu Ile Pro
         195                 200                 205            
 Leu Ile Tyr Leu Glu Asn Pro Arg Arg Asn Arg Ile Ala Gln Trp Gln
     210                 215                 220                
 Ser Leu Lys Leu Glu Ala Gly Ile Asn Gln Leu Ser Phe Pro Leu Ser
 225                 230                 235                 240
 Ser Glu Pro Ile Gln Gly Ser Tyr Arg Val Val Val Gln Thr Glu Ser
                 245                 250                 255    
 Gly Gly Arg Ile Gln His Pro Phe Thr Val Glu Glu Phe Val Leu Pro
             260                 265                 270        
 Lys Phe Glu Val Lys Val Gln Val Pro Lys Ile Ile Ser Ile Met Asp
         275                 280                 285            
 Glu Lys Val Asn Ile Thr Val Cys Gly Glu Tyr Thr Tyr Gly Lys Pro
     290                 295                 300                
 Val Pro Gly Leu Ala Thr Val Ser Leu Cys Arg Lys Leu Ser Arg Val
 305                 310                 315                 320
 Leu Asn Cys Asp Lys Gln Glu Val Cys Glu Glu Phe Ser Gln Gln Leu
                 325                 330                 335    
 Asn Ser Asn Gly Cys Ile Thr Gln Gln Val His Thr Lys Met Leu Gln
             340                 345                 350        
 Ile Thr Asn Thr Gly Phe Glu Met Lys Leu Arg Val Glu Ala Arg Ile
         355                 360                 365            
 Arg Glu Glu Gly Thr Asp Leu Glu Val Thr Ala Asn Arg Ile Ser Glu
     370                 375                 380                
 Ile Thr Asn Ile Val Ser Lys Leu Lys Phe Val Lys Val Asp Ser His
 385                 390                 395                 400
 Phe Arg Gln Gly Ile Pro Phe Phe Ala Gln Val Leu Leu Val Asp Gly
                 405                 410                 415    
 Lys Gly Val Pro Ile Pro Asn Lys Leu Phe Phe Ile Ser Val Asn Asp
             420                 425                 430        
 Ala Asn Tyr Tyr Ser Asn Ala Thr Thr Asn Glu Gln Gly Leu Ala Gln
         435                 440                 445            
 Phe Ser Ile Asn Thr Thr Ser Ile Ser Val Asn Lys Leu Phe Val Arg
     450                 455                 460                
 Val Phe Thr Val His Pro Asn Leu Cys Phe His Tyr Ser Trp Val Ala
 465                 470                 475                 480
 Glu Asp His Gln Gly Ala Gln His Thr Ala Asn Arg Val Phe Ser Leu
                 485                 490                 495    
 Ser Gly Ser Tyr Ile His Leu Glu Pro Val Ala Gly Thr Leu Pro Cys
             500                 505                 510        
 Gly His Thr Glu Thr Ile Thr Ala His Tyr Thr Leu Asn Arg Gln Ala
         515                 520                 525            
 Met Gly Glu Leu Ser Glu Leu Ser Phe His Tyr Leu Ile Met Ala Lys
     530                 535                 540                
 Gly Val Ile Val Arg Ser Gly Thr His Thr Leu Pro Val Glu Ser Gly
 545                 550                 555                 560
 Asp Met Lys Gly Ser Phe Ala Leu Ser Phe Pro Val Glu Ser Asp Val
                 565                 570                 575    
 Ala Pro Ile Ala Arg Met Phe Ile Phe Ala Ile Leu Pro Asp Gly Glu
             580                 585                 590        
 Val Val Gly Asp Ser Glu Lys Phe Glu Ile Glu Asn Cys Leu Ala Asn
         595                 600                 605            
 Lys Val Asp Leu Ser Phe Ser Pro Ala Gln Ser Pro Pro Ala Ser His
     610                 615                 620                
 Ala His Leu Gln Val Ala Ala Ala Pro Gln Ser Leu Cys Ala Leu Arg
 625                 630                 635                 640
 Ala Val Asp Gln Ser Val Leu Leu Met Lys Pro Glu Ala Glu Leu Ser
                 645                 650                 655    
 Val Ser Ser Tyr Asp Ile Gly Cys Val Phe Val Ile Tyr Gly Ser Tyr
             660                 665                 670        
 Glu Val Tyr Asn Leu Leu Thr Val Lys Asp Leu Thr Asn Phe Pro Asp
         675                 680                 685            
 Asn Val Asp Gln Gln Glu Glu Glu Gln Gly His Cys Pro Arg Pro Phe
     690                 695                 700                
 Phe Ile His Asn Gly Ala Ile Tyr Val Pro Leu Ser Ser Asn Glu Ala
 705                 710                 715                 720
 Asp Ile Tyr Ser Phe Leu Lys Gly Met Gly Leu Lys Val Phe Thr Asn
                 725                 730                 735    
 Ser Lys Ile Arg Lys Pro Lys Ser Cys Ser Val Ile Pro Ser Val Ser
             740                 745                 750        
 Ala Gly Ala Val Gly Gln Gly Tyr Tyr Gly Gly Thr Tyr Asn Val Ile
         755                 760                 765            
 Pro Leu Asn Asn Glu Gln Ser Ser Gly Pro Val Pro Glu Thr Val Arg
     770                 775                 780                
 Ser Tyr Phe Pro Glu Thr Trp Ile Trp Glu Leu Val Ala Val Asn Ser
 785                 790                 795                 800
 Ser Gly Val Ala Glu Val Gly Val Thr Val Pro Asp Thr Ile Thr Glu
                 805                 810                 815    
 Trp Lys Ala Gly Ala Phe Cys Leu Ser Glu Asp Ala Gly Leu Gly Ile
             820                 825                 830        
 Ser Ser Thr Ala Ser Leu Arg Ala Phe Gln Pro Phe Phe Val Glu Leu
         835                 840                 845            
 Thr Met Pro Tyr Ser Val Ile Arg Gly Glu Val Phe Thr Leu Lys Ala
     850                 855                 860                
 Thr Val Leu Asn Tyr Leu Pro Lys Cys Ile Arg Val Arg Lys Met Arg
 865                 870                 875                 880
 Val Asn Arg Lys Gly Asn Val Asn Phe Ser Val Ser Ala Glu Ala Met
                 885                 890                 895    
 Gln Ser Leu Glu Leu Cys Gly Asn Glu Val Val Glu Val Pro Glu Ile
             900                 905                 910        
 Lys Arg Lys Asp Thr Val Ile Lys Thr Leu Leu Val Glu Ala Glu Gly
         915                 920                 925            
 Ile Glu Gln Glu Lys Thr Phe Ser Ser Met Thr Cys Ala Ser Gly Ala
     930                 935                 940                
 Asn Val Ser Glu Gln Leu Ser Leu Lys Leu Pro Ser Asn Val Val Lys
 945                 950                 955                 960
 Glu Ser Ala Arg Ala Ser Phe Ser Val Leu Gly Asp Ile Leu Gly Ser
                 965                 970                 975    
 Ala Met Gln Asn Ile Gln Asn Leu Leu Gln Met Pro Tyr Gly Cys Gly
             980                 985                 990        
 Glu Gln Asn Met Val Leu Phe Ala Pro Asn Ile Tyr Val Leu Asn Tyr
         995                1000                1005            
 Leu Asn Glu Thr Gln Gln Leu Thr Gln Glu Ile Lys Ala Lys Ala Val
    1010                1015                1020                
 Gly Tyr Leu Ile Thr Gly Tyr Gln Arg Gln Leu Asn Tyr Lys His Gln
1025                1030                1035                1040
 Asp Gly Ser Tyr Ser Thr Phe Gly Glu Arg Tyr Gly Arg Asn Gln Gly
                1045                1050                1055    
 Asn Thr Trp Leu Thr Ala Phe Val Leu Lys Thr Phe Ala Gln Ala Arg
            1060                1065                1070        
 Ser Tyr Ile Phe Ile Asp Glu Ala His Ile Thr Gln Ser Leu Thr Trp
        1075                1080                1085            
 Leu Ser Gln Met Gln Lys Asp Asn Gly Cys Phe Arg Ser Ser Gly Ser
    1090                1095                1100                
 Leu Leu Asn Asn Ala Ile Lys Asn Pro Ile Val Arg Asn Ala Leu Phe
1105                1110                1115                1120
 Cys Leu Glu Ser Ala Trp Asn Val Ala Lys Glu Gly Thr His Gly Ser
                1125                1130                1135    
 His Val Tyr Thr Lys Ala Leu Leu Ala Tyr Ala Phe Ser Leu Leu Gly
            1140                1145                1150        
 Lys Gln Asn Gln Asn Arg Glu Ile Leu Asn Ser Leu Asp Lys Glu Ala
        1155                1160                1165            
 Val Lys Glu Asp Pro Glu Met Glu Glu Gly Leu Cys Leu Glu Val Glu
    1170                1175                1180                
 Gly Lys Met Val Ser Arg Thr Lys Gly Asp Ile Asp Asp Ser Leu Ile
1185                1190                1195                1200
 Gly Gly Asp Ala Phe Thr Glu Val Ser Gln Ser Glu Ala Lys Arg Ser
                1205                1210                1215    
 Arg Ser Asn Lys Asn Tyr Gln Phe Phe Ile Gly Glu Asn Met Asn Pro
            1220                1225                1230        
 Tyr Gly Met Leu Pro Leu Leu Asp Tyr His Glu Asp Asp Asn Leu Val
        1235                1240                1245            
 His Trp Glu Arg Pro Gln Arg Pro Lys Ala Pro Val Gly His Leu Tyr
    1250                1255                1260                
 Gln Thr Gln Ala Pro Ser Ala Glu Val Glu Met Thr Ser Tyr Val Leu
1265                1270                1275                1280
 Leu Ala Tyr Leu Thr Ala Gln Pro Ala Pro Thr Ser Gly Asp Leu Thr
                1285                1290                1295    
 Ser Ala Thr Asn Ile Val Lys Trp Ile Met Lys Gln Gln Asn Ala Gln
            1300                1305                1310        
 Gly Gly Phe Ser Ser Thr Gln Asp Thr Val Val Ala Leu His Ala Leu
        1315                1320                1325            
 Ser Arg Tyr Gly Ala Ala Thr Phe Thr Arg Thr Glu Lys Thr Ala Gln
    1330                1335                1340                
 Val Thr Val Gln Asp Ser Gln Thr Phe Ser Thr Asn Phe Gln Val Asp
1345                1350                1355                1360
 Asn Asn Asn Leu Leu Leu Leu Gln Gln Ile Ser Leu Pro Glu Leu Pro
                1365                1370                1375    
 Gly Glu Tyr Val Ile Thr Val Thr Gly Glu Arg Cys Val Tyr Leu Gln
            1380                1385                1390        
 Thr Ser Met Lys Tyr Asn Ile Leu Pro Glu Lys Glu Asp Ser Pro Phe
        1395                1400                1405            
 Ala Leu Lys Val Gln Thr Val Pro Gln Thr Cys Asp Gly His Lys Ala
    1410                1415                1420                
 His Thr Ser Phe Gln Ile Ser Leu Thr Ile Ser Tyr Thr Gly Asn Arg
1425                1430                1435                1440
 Pro Ala Ser Asn Met Val Ile Val Asp Val Lys Met Val Ser Gly Phe
                1445                1450                1455    
 Ile Pro Leu Lys Pro Thr Val Lys Met Leu Glu Arg Ser Ser Ser Val
            1460                1465                1470        
 Ser Arg Thr Glu Val Ser Asn Asn His Val Leu Ile Tyr Val Glu Gln
        1475                1480                1485            
 Val Thr Asn Gln Thr Leu Ser Phe Ser Phe Met Val Leu Gln Asp Ile
    1490                1495                1500                
 Pro Val Gly Asp Leu Lys Pro Ala Ile Val Lys Val Tyr Asp Tyr Tyr
1505                1510                1515                1520
 Glu Thr Asp Glu Ser Val Val Ala Glu Tyr Ile Ala Pro Cys Ser Thr
                1525                1530                1535    
 Asp Thr Glu His Gly Asn Val
            1540            



      <210> 1718
      <211> 614
      <212> PRT
      <213> Homo sapiens


      <400> 1718
 Met Arg Pro Arg Pro Glu Gly Arg Gly Leu Arg Ala Gly Val Ala Leu
   1               5                  10                  15    
 Ser Pro Ala Leu Leu Leu Leu Leu Leu Leu Pro Pro Pro Pro Thr Leu
              20                  25                  30        
 Leu Gly Arg Leu Trp Ala Ala Gly Thr Pro Ser Pro Ser Ala Pro Gly
          35                  40                  45            
 Ala Arg Gln Asp Gly Ala Leu Gly Ala Gly Arg Val Lys Arg Gly Trp
      50                  55                  60                
 Val Trp Asn Gln Phe Phe Val Val Glu Glu Tyr Thr Gly Thr Glu Pro
  65                  70                  75                  80
 Leu Tyr Val Gly Lys Ile His Ser Asp Ser Asp Glu Gly Asp Gly Ala
                  85                  90                  95    
 Ile Lys Tyr Thr Ile Ser Gly Glu Gly Ala Gly Thr Ile Phe Leu Ile
             100                 105                 110        
 Asp Glu Leu Thr Gly Asp Ile His Ala Met Glu Arg Leu Asp Arg Glu
         115                 120                 125            
 Gln Lys Thr Phe Tyr Thr Leu Arg Ala Gln Ala Arg Asp Arg Ala Thr
     130                 135                 140                
 Asn Arg Leu Leu Glu Pro Glu Ser Glu Phe Ile Ile Lys Val Gln Asp
 145                 150                 155                 160
 Ile Asn Asp Ser Glu Pro Arg Phe Leu His Gly Pro Tyr Ile Gly Ser
                 165                 170                 175    
 Val Ala Glu Leu Ser Pro Thr Gly Thr Ser Val Met Gln Val Met Ala
             180                 185                 190        
 Ser Asp Ala Asp Asp Pro Thr Tyr Gly Ser Ser Ala Arg Leu Val Tyr
         195                 200                 205            
 Ser Val Leu Asp Gly Glu His His Phe Thr Val Asp Pro Lys Thr Glu
     210                 215                 220                
 Glu Glu Glu Glu Glu Glu Glu Glu Glu Glu Glu Glu Glu Glu Glu Glu
 225                 230                 235                 240
 Glu Glu Glu Gly Val Ala Arg Pro Arg Phe Gln Arg Arg Ala Phe Gln
                 245                 250                 255    
 Asp Asn Phe Gln Glu Val Glu Lys Leu Gly Gln Arg Ala His Ala Phe
             260                 265                 270        
 Gly Ile Ser Ile Asp Asn Ala Glu Met Tyr Gln Thr Thr Leu Pro Pro
         275                 280                 285            
 Tyr Arg His Gly Met Asn Lys Thr Ser Met Asp Phe Cys Leu Cys Glu
     290                 295                 300                
 Thr Cys Leu Trp Arg Tyr Ser Ile Gln Asn Leu Arg Lys Glu Ile Ser
 305                 310                 315                 320
 Lys Ala Ser Pro Lys Cys Glu Ala Cys Cys Trp Lys Leu Pro Leu Ile
                 325                 330                 335    
 Gln Ser Ser Gln Gln Pro Tyr Gln Gly Gly Glu Tyr Asp Thr Pro His
             340                 345                 350        
 Leu Pro Cys Thr Ala Pro Ala Val Gln Gly Cys Lys Ala Ser Ala Ser
         355                 360                 365            
 Trp Leu Cys Thr Phe Tyr Thr Cys Asp Leu Gln Gln Gly Val Ile Arg
     370                 375                 380                
 Thr Ala Val Pro Asp Leu Asp Arg Glu Ser Gln Glu Arg Tyr Glu Val
 385                 390                 395                 400
 Val Ile Gln Ala Thr Asp Met Ala Gly Gln Leu Gly Gly Leu Ser Gly
                 405                 410                 415    
 Ser Thr Thr Val Thr Ile Val Val Thr Asp Val Asn Asp Asn Pro Pro
             420                 425                 430        
 Arg Phe Pro Gln Lys Met Tyr Gln Phe Ser Ile Gln Glu Ser Ala Pro
         435                 440                 445            
 Ile Gly Thr Ala Val Gly Arg Val Lys Ala Glu Asp Ser Asp Val Gly
     450                 455                 460                
 Glu Asn Thr Asp Met Thr Tyr His Leu Lys Asp Glu Ser Ser Ser Gly
 465                 470                 475                 480
 Gly Asp Val Phe Lys Val Thr Thr Asp Ser Asp Thr Gln Glu Ala Ile
                 485                 490                 495    
 Ile Val Val Gln Lys Arg Leu Asp Phe Glu Ser Gln Pro Val His Thr
             500                 505                 510        
 Val Ile Leu Glu Ala Leu Asn Lys Phe Val Asp Pro Arg Phe Ala Asp
         515                 520                 525            
 Leu Gly Thr Phe Arg Asp Gln Ala Ile Val Arg Val Ala Val Thr Asp
     530                 535                 540                
 Val Asp Glu Pro Pro Glu Phe Arg Pro Pro Ser Gly Leu Leu Glu Val
 545                 550                 555                 560
 Gln Glu Asp Ala Gln Val Gly Ser Leu Val Gly Val Val Thr Ala Arg
                 565                 570                 575    
 Asp Pro Asp Ala Ala Asn Arg Pro Val Arg Ile Val Ala Gly Ala Ser
             580                 585                 590        
 Leu Ile Leu Leu Lys Cys Glu Leu Glu Pro Gly Pro Ala Leu Pro Lys
         595                 600                 605            
 Pro Ser Lys Asp Thr Tyr
     610                



      <210> 1719
      <211> 258
      <212> PRT
      <213> Homo sapiens


      <400> 1719
 Met Lys Asn Leu Pro Arg Ala Cys Ser Ala Leu Pro Arg Leu Leu Ala
   1               5                  10                  15    
 Leu Ser Trp Tyr Ser Leu Lys His Ile Arg Leu Gly Ser Tyr Ser Gly
              20                  25                  30        
 Thr Gly Met Gly Phe Asn Arg Ala Leu Glu Lys Ala Arg Met Lys Gln
          35                  40                  45            
 Glu Ile Trp Lys Pro Gly Pro Arg Leu Gln Arg Trp Leu Ile Lys Gly
      50                  55                  60                
 Leu Gly Lys Val Ile Pro Cys Leu Thr Pro Val Val Ser Ile Gln His
  65                  70                  75                  80
 Leu Leu Val Thr Lys Leu Ser Ala Phe Gln Gly Ile Ile Val Thr Gly
                  85                  90                  95    
 Asp Ile Val Thr Gly Asp His Glu Asp Met Val Pro Leu Ile Leu Thr
             100                 105                 110        
 Thr Asp Ser Lys Arg Asp Phe Leu Ala Arg Glu Arg Leu Gln Gly His
         115                 120                 125            
 Leu Ala Trp Ala Pro Gly Glu Asn Gln Pro Val Ile His Val Leu Ile
     130                 135                 140                
 Arg Glu Pro Thr Lys Val Lys Val Arg Ser Val Gln Leu Gln Thr Pro
 145                 150                 155                 160
 Pro Gln Thr Ser Glu Pro Gln Cys Gly Asp Lys Glu Arg Ser Ser Ser
                 165                 170                 175    
 Pro Ala Met Glu Gln Ser Trp Thr Glu Asn Asp Phe Asp Glu Leu Arg
             180                 185                 190        
 Glu Glu Gly Phe Arg Lys Ser Asn Phe Ser Glu Leu Lys Glu Glu Val
         195                 200                 205            
 Arg Ile His Gly Lys Glu Val Lys Asn Leu Glu Lys Arg Leu Asn Arg
     210                 215                 220                
 Gly Leu Thr Lys Ile Thr Asn Ala Glu Lys Ser Leu Lys Asp Leu Val
 225                 230                 235                 240
 Glu Leu Lys Thr Met Ala Gln Glu Leu His Asp Glu Cys Thr Ser Phe
                 245                 250                 255    
 Ser Ser
        



      <210> 1720
      <211> 146
      <212> PRT
      <213> Homo sapiens


      <400> 1720
 Met Gln Met Thr Gly Pro Ile Ser Asp Leu Trp Thr His Met Ser Glu
   1               5                  10                  15    
 Pro Leu Gly Pro Val Glu Leu Ala Leu Thr Ser Ile Leu Thr Leu Leu
              20                  25                  30        
 Ala Leu Gly Ser Ile Ala Ile Phe Leu Glu Asp Ala Val Tyr Leu Tyr
          35                  40                  45            
 Lys Asn Thr Leu Cys Pro Ile Lys Arg Arg Thr Leu Leu Trp Lys Ser
      50                  55                  60                
 Ser Ala Pro Thr Val Val Ser Val Leu Cys Cys Phe Gly Leu Trp Ile
  65                  70                  75                  80
 Pro Arg Ser Leu Val Leu Val Glu Met Thr Ile Thr Ser Phe Tyr Ala
                  85                  90                  95    
 Val Cys Phe Tyr Leu Leu Met Leu Val Met Val Glu Gly Phe Gly Gly
             100                 105                 110        
 Lys Glu Ala Val Leu Arg Thr Leu Arg Asp Thr Pro Met Met Val His
         115                 120                 125            
 Thr Gly Pro Cys Cys Cys Cys Cys Pro Cys Cys Pro Arg Leu Leu Leu
     130                 135                 140                
 Thr Arg
 145    



      <210> 1721
      <211> 295
      <212> PRT
      <213> Homo sapiens


      <400> 1721
 Met Asp Lys Val Asp Glu Val Ser Pro Cys Ala Phe Gln Thr Ala Val
   1               5                  10                  15    
 Val Gln Lys Leu Leu Val Cys Gly Leu Ser Leu Leu Phe His Leu Thr
              20                  25                  30        
 Ile Cys Thr Thr Leu Pro Val Glu Tyr Asn Ile Asp Glu His Phe Gln
          35                  40                  45            
 Ala Thr Ala Ser Trp Pro Thr Lys Ile Ile Tyr Leu Tyr Ile Ser Leu
      50                  55                  60                
 Leu Ala Ala Arg Pro Lys Tyr Tyr Phe Ala Trp Thr Leu Ala Asp Ala
  65                  70                  75                  80
 Ile Asn Asn Ala Ala Gly Phe Gly Phe Arg Gly Tyr Asp Glu Asn Gly
                  85                  90                  95    
 Ala Ala Arg Trp Asp Leu Ile Ser Asn Leu Arg Ile Gln Gln Ile Glu
             100                 105                 110        
 Val Tyr Gly Asp Ser Phe His Leu Asp Lys Glu Gln Arg Ile Asp Met
         115                 120                 125            
 Ser Leu Lys Gly Gln Ile Ile Ser Ser Asn His Arg Leu Ser Glu Leu
     130                 135                 140                
 Ser Thr Arg Gln Ile Met Val Arg His Ser Ala Glu Ala Pro Glu Leu
 145                 150                 155                 160
 Glu Ser Glu Ile Trp Glu Leu Ser Ala Arg Gly Ser Ser Gly Pro Gly
                 165                 170                 175    
 Gly Glu Asn Gln Lys Arg Cys Gln Gln Val Ser Arg Cys Phe Leu Ile
             180                 185                 190        
 Ile Gly Ile Phe Arg Gln Leu Phe Gly Ser Lys Glu Phe Ser Glu Gly
         195                 200                 205            
 Glu Ile Lys Thr Glu Leu Asn Lys Asp Asp Gln Asn Gly Ser Trp Tyr
     210                 215                 220                
 Tyr Cys Leu His Ile Leu Gly Ile Leu Val Leu Leu Leu Leu Pro Val
 225                 230                 235                 240
 Lys Lys Thr Gln Arg Arg Lys Asn Thr His Glu Asn Ile Gln Leu Ser
                 245                 250                 255    
 Gln Ser Lys Lys Phe Asp Glu Gly Glu Asn Ser Leu Gly Gln Asn Ser
             260                 265                 270        
 Phe Ser Thr Thr Asn Asn Val Cys Asn Gln Asn Gln Glu Ile Ala Ser
         275                 280                 285            
 Arg His Ser Ser Leu Lys Gln
     290                 295



      <210> 1722
      <211> 533
      <212> PRT
      <213> Homo sapiens


      <400> 1722
 Met Leu Gly Val Ala Leu Val Ala Gly Ala Leu Gly Ala Gly Val Val
   1               5                  10                  15    
 Ala Ala Ala Ala Ala Leu Leu Leu Val Ala Leu Ala Val Ala Pro Ala
              20                  25                  30        
 Ile Ala Leu Cys Trp Gly Ala Val Leu Ala Ser Pro Ala Val Tyr Leu
          35                  40                  45            
 Ile Leu Asp Gly Val Val Val Ala Ala Phe Val Val Val Ala Val Cys
      50                  55                  60                
 Thr Asp Arg Ser Ser Gly Ala Pro Ser Gly Gly Gly Trp Ile Gly Gly
  65                  70                  75                  80
 Cys Gly Phe Glu Arg Pro Gly Gly Arg Trp Gly Pro Cys Asn Asn Tyr
                  85                  90                  95    
 Gln Thr Leu Thr Leu Cys Gln Tyr Leu Val Leu Tyr Lys Asp His Leu
             100                 105                 110        
 Thr Glu Ala Pro Gln Lys Pro Phe Gln Tyr Gly Pro Val Phe Ser Phe
         115                 120                 125            
 Thr Met Val Gly Lys Thr Phe Thr Tyr Leu Leu Gly Ser Asp Ala Ala
     130                 135                 140                
 Ala Leu Leu Phe Asn Ser Lys Asn Glu Asp Leu Asn Ala Glu Asp Val
 145                 150                 155                 160
 Tyr Ser Arg Leu Thr Thr Pro Val Phe Gly Lys Gly Val Ala Tyr Asp
                 165                 170                 175    
 Val Pro Asn Pro Val Phe Leu Glu Gln Lys Lys Met Leu Lys Ser Gly
             180                 185                 190        
 Leu Asn Ile Ala His Phe Lys Gln His Val Ser Ile Ile Glu Lys Glu
         195                 200                 205            
 Thr Lys Glu Tyr Phe Glu Ser Trp Gly Glu Ser Gly Glu Lys Asn Val
     210                 215                 220                
 Phe Glu Ala Leu Ser Glu Leu Ile Ile Leu Thr Ala Ser His Cys Leu
 225                 230                 235                 240
 His Gly Lys Glu Ile Arg Ser Gln Leu Asn Glu Lys Val Ala Gln Leu
                 245                 250                 255    
 Tyr Ala Asp Leu Asp Gly Gly Phe Ser His Ala Ala Trp Leu Leu Pro
             260                 265                 270        
 Gly Trp Leu Pro Leu Pro Ser Phe Arg Arg Arg Asp Arg Ala His Arg
         275                 280                 285            
 Glu Ile Lys Asp Ile Phe Tyr Lys Ala Ile Gln Lys Arg Arg Gln Ser
     290                 295                 300                
 Gln Glu Lys Ile Asp Asp Ile Leu Gln Thr Leu Leu Asp Ala Thr Tyr
 305                 310                 315                 320
 Lys Asp Gly Arg Pro Leu Thr Asp Asp Glu Val Ala Gly Met Leu Ile
                 325                 330                 335    
 Gly Leu Leu Leu Ala Gly Gln His Thr Ser Ser Thr Thr Ser Ala Trp
             340                 345                 350        
 Met Gly Phe Phe Leu Ala Arg Asp Lys Thr Leu Gln Lys Lys Cys Tyr
         355                 360                 365            
 Leu Glu Gln Lys Thr Val Cys Gly Glu Asn Leu Pro Pro Leu Thr Tyr
     370                 375                 380                
 Asp Gln Leu Lys Asp Leu Asn Leu Leu Asp Arg Cys Ile Lys Glu Thr
 385                 390                 395                 400
 Leu Arg Leu Arg Pro Pro Ile Met Ile Met Met Arg Met Ala Arg Thr
                 405                 410                 415    
 Pro Gln Thr Val Ala Gly Tyr Thr Ile Pro Pro Gly His Gln Val Cys
             420                 425                 430        
 Val Ser Pro Thr Val Asn Gln Arg Leu Lys Asp Ser Trp Val Glu Arg
         435                 440                 445            
 Leu Asp Phe Asn Pro Asp Arg Tyr Leu Gln Asp Asn Pro Ala Ser Gly
     450                 455                 460                
 Glu Lys Phe Ala Tyr Val Pro Phe Gly Ala Gly Arg His Arg Cys Ile
 465                 470                 475                 480
 Gly Glu Asn Phe Ala Tyr Val Gln Ile Lys Thr Ile Trp Ser Thr Met
                 485                 490                 495    
 Leu Arg Leu Tyr Glu Phe Asp Leu Ile Asp Gly Tyr Phe Pro Thr Val
             500                 505                 510        
 Asn Tyr Thr Thr Met Ile His Thr Pro Glu Asn Pro Val Ile Arg Tyr
         515                 520                 525            
 Lys Arg Arg Ser Lys
     530            



      <210> 1723
      <211> 552
      <212> PRT
      <213> Homo sapiens


      <400> 1723
 Met Arg Glu His Lys Gly Gly His Phe Gly Ser Leu Gly Phe Gly Val
   1               5                  10                  15    
 Ile His Leu Val Phe Thr Asn Leu Leu Leu Trp Ala Asn Gly Val Leu
              20                  25                  30        
 Asn Glu Ser Lys His Gln Leu Asn Glu His Lys Glu Trp Leu Ile Thr
          35                  40                  45            
 Leu Gly Phe Gly Asn Ile Thr Thr Val Leu Asp Asp His Thr Pro Gln
      50                  55                  60                
 Cys Asn Cys Thr Pro Pro Thr Leu Cys Thr Thr Ile Ser His Gly Ile
  65                  70                  75                  80
 Tyr Tyr Asn Tyr Tyr Leu Tyr Pro Phe Asn Ile Glu Tyr Gln Ile Leu
                  85                  90                  95    
 Ala Ser Thr Val Leu Tyr Val Leu Trp Lys Asn Ile Gly Arg Lys Val
             100                 105                 110        
 Asp Ser His Gln His Gln Lys Met Gln Phe Lys Pro Asp Gly Val Thr
         115                 120                 125            
 Val Gly Thr Val Leu Gly Leu Thr Ala Leu Ala Ala Thr Ile Ala Val
     130                 135                 140                
 Val Thr Lys Ser Glu Ser Ala Leu Ile Thr Phe Tyr Leu Tyr Val Ile
 145                 150                 155                 160
 Thr Leu Met Met Leu Met Gly Ala Ala Gly Leu Ala Gly Ile Arg Ile
                 165                 170                 175    
 Tyr Arg Thr Asp Glu Lys Ser Leu Asp Glu Ser Lys Asn Pro Pro Arg
             180                 185                 190        
 Lys Leu Asp Ser Asp Leu Leu Val Gly Thr Ala Ser Gly Ser Trp Leu
         195                 200                 205            
 Ile Ser Trp Gly Ser Ile Leu Ala Ile Leu Cys Ala Glu Asp His Pro
     210                 215                 220                
 His Tyr Thr Trp Tyr Asn Leu Pro Tyr Ser Ile Val Val Ile Met Glu
 225                 230                 235                 240
 Lys Tyr Ile Gln Asn Leu Phe Ile Phe Glu Ser Ile His Arg Glu Pro
                 245                 250                 255    
 Lys Lys Leu Ser Glu Asp Ile Gln Thr Leu Arg Met Val Thr Val Cys
             260                 265                 270        
 Asn Gly Asn Thr Met Ser Leu Ala Ser Ser Cys Leu Lys Ser Gly Val
         275                 280                 285            
 Val Ala Gly Asp Val Ala Pro Trp Gly Arg Asp Met Pro Pro Ala Ala
     290                 295                 300                
 Asn Gly Asn Val Cys Leu Arg Glu Ser Cys Asp Lys Glu Glu Lys Gln
 305                 310                 315                 320
 Glu Glu Ser Ser Trp Gly Gly Asn Pro Ser Pro Val His Leu Pro Arg
                 325                 330                 335    
 Phe Leu Gln Gly Asn Ala Lys Arg Lys Val Leu Arg Asn Ile Ala Ala
             340                 345                 350        
 Phe Leu Phe Leu Cys Asn Thr Leu Val Gln Gly Val Arg Met Gln Ile
         355                 360                 365            
 Cys Tyr Met Gly Lys Leu Arg Val Ala Glu Val Trp Cys Thr Asn Asp
     370                 375                 380                
 Pro Val Thr Gln Val Val Pro Lys Ala Ser Gly Arg Glu Gln Glu Leu
 385                 390                 395                 400
 Ser Ser Pro Ala Ser Gly Ala Ser Pro Glu Ala Pro Ala Ala Gly Ala
                 405                 410                 415    
 Asp Val His Val Gln Val Glu Trp Ala Pro Leu Gln Arg Arg Thr Trp
             420                 425                 430        
 Lys Cys Ala Ser Val Ala Ser Lys Trp Thr Asn Pro Val Asp Arg Glu
         435                 440                 445            
 Val Glu Lys Glu Gly Val Gly Asn Ser Ser Trp Ala Ala Ile Val Asp
     450                 455                 460                
 Gln Met Asp Gln Leu Ser Gly Lys Ala Ser Leu Lys Gly Asp Met Arg
 465                 470                 475                 480
 Gln Glu Gly Val Gly His Ala Cys Ser Gly Gln Arg Glu Gln Arg Leu
                 485                 490                 495    
 Leu Trp Ile Pro Pro Ala Phe Gly Cys Arg Pro Glu Tyr Asp Asn Gly
             500                 505                 510        
 Leu Glu Glu Ile Val Phe Gly Phe Glu Pro Trp Ile Ile Val Val Asn
         515                 520                 525            
 Leu Ala Met Pro Phe Ser Ile Phe Tyr Gly Met His Ala Ala Ala Ser
     530                 535                 540                
 Leu Phe Glu Val Tyr Cys Lys Ile
 545                 550        



      <210> 1724
      <211> 602
      <212> PRT
      <213> Homo sapiens


      <400> 1724
 Met Asn Arg Ile Arg Lys Phe Phe Arg Gly Ser Gly Arg Val Leu Ala
   1               5                  10                  15    
 Phe Ile Phe Val Ala Ser Val Ile Trp Leu Leu Phe Asp Met Ala Ala
              20                  25                  30        
 Leu Arg Leu Ser Phe Ser Glu Ile Asn Thr Arg Val Ile Lys Glu Asp
          35                  40                  45            
 Ile Val Arg Arg Glu Arg Ile Gly Phe Arg Val Gln Pro Asp Gln Gly
      50                  55                  60                
 Lys Ile Phe Tyr Ser Ser Ile Lys Glu Met Lys Pro Pro Leu Arg Gly
  65                  70                  75                  80
 His Gly Lys Gly Ala Trp Gly Lys Glu Asn Val Arg Lys Thr Glu Glu
                  85                  90                  95    
 Ser Val Leu Lys Val Glu Val Asp Leu Asp Gln Thr Gln Arg Glu Arg
             100                 105                 110        
 Lys Met Gln Asn Ala Leu Gly Arg Gly Lys Val Val Pro Leu Trp His
         115                 120                 125            
 Pro Ala His Leu Gln Thr Leu Pro Val Thr Pro Asn Lys Gln Lys Thr
     130                 135                 140                
 Asp Gly Arg Gly Thr Lys Pro Glu Ala Ser Ser His Gln Gly Thr Pro
 145                 150                 155                 160
 Lys Gln Thr Thr Ala Gln Gly Ala Pro Lys Thr Ser Phe Ile Ala Ala
                 165                 170                 175    
 Lys Gly Thr Gln Val Val Lys Ile Ser Val His Met Gly Arg Val Ser
             180                 185                 190        
 Leu Lys Gln Glu Pro Arg Lys Ser His Ser Pro Ser Ser Asp Thr Ser
         195                 200                 205            
 Lys Leu Ala Ala Glu Arg Asp Leu Asn Val Thr Ile Ser Leu Ser Thr
     210                 215                 220                
 Asp Arg Pro Lys Gln Arg Ser Gln Ala Val Ala Asn Glu Arg Ala His
 225                 230                 235                 240
 Pro Ala Ser Thr Ala Val Pro Lys Ser Gly Glu Ala Met Ala Leu Asn
                 245                 250                 255    
 Lys Thr Lys Thr Gln Ser Lys Glu Val Asn Ala Asn Lys His Lys Ala
             260                 265                 270        
 Asn Thr Ser Leu Pro Phe Pro Lys Phe Thr Val Asn Ser Asn Arg Leu
         275                 280                 285            
 Arg Lys Gln Ser Ile Asn Glu Thr Pro Leu Gly Ser Leu Ser Lys Asp
     290                 295                 300                
 Asp Gly Ala Arg Gly Ala His Gly Lys Lys Leu Asn Phe Ser Glu Ser
 305                 310                 315                 320
 His Leu Val Ile Ile Thr Lys Glu Glu Glu Gln Lys Ala Asp Pro Lys
                 325                 330                 335    
 Glu Val Ser Asn Ser Lys Thr Lys Thr Ile Phe Pro Lys Val Leu Gly
             340                 345                 350        
 Lys Ser Gln Ser Lys His Ile Ser Arg Asn Arg Ser Glu Met Ser Ser
         355                 360                 365            
 Ser Ser Leu Ala Pro His Arg Val Pro Leu Ser Gln Thr Asn His Ala
     370                 375                 380                
 Leu Thr Gly Gly Leu Glu Pro Ala Lys Ile Asn Ile Thr Ala Lys Ala
 385                 390                 395                 400
 Pro Ser Thr Glu Tyr Asn Gln Ser His Ile Lys Ala Leu Leu Pro Glu
                 405                 410                 415    
 Asp Ser Gly Thr His Gln Val Leu Arg Ile Asp Val Thr Leu Ser Pro
             420                 425                 430        
 Arg Asp Pro Lys Ala Pro Gly Gln Phe Gly Arg Pro Val Val Val Pro
         435                 440                 445            
 His Gly Lys Glu Lys Glu Ala Glu Arg Arg Trp Lys Glu Gly Asn Phe
     450                 455                 460                
 Asn Val Tyr Leu Ser Asp Leu Ile Pro Val Asp Arg Ala Ile Glu Asp
 465                 470                 475                 480
 Thr Arg Pro Ala Gly Gly Leu Met Thr Gln Arg Lys Ala Leu Thr Ala
                 485                 490                 495    
 Gln Thr Leu Ser Gln Lys Lys Lys Lys Cys Glu Ser Val Val Arg Asp
             500                 505                 510        
 Gly Ile Ser Met Lys Gly Ile Phe Lys Ile Gly Thr Lys Gly Ile Glu
         515                 520                 525            
 Ala Ala Ser Cys Glu Asp Met Gly Arg Val Ala Lys Met Leu Glu Val
     530                 535                 540                
 Lys Gln Ile Thr Lys Ala Gly Val Phe Phe Arg Glu Leu Lys Glu Gly
 545                 550                 555                 560
 Gln Gly Gly Lys Leu Thr Glu Asp Phe Lys Gln Lys Ser Gly Val Asp
                 565                 570                 575    
 Leu Thr Asn Cys Gly Ser Ser Val Pro Leu Gly Asp Ser Ser Asn Asn
             580                 585                 590        
 Pro Gly Glu Arg Glu Trp Met Leu Lys Ser
         595                 600        



      <210> 1725
      <211> 565
      <212> PRT
      <213> Homo sapiens


      <400> 1725
 Met Trp Pro Leu Val Ala Ala Leu Leu Leu Gly Ser Ala Cys Cys Gly
   1               5                  10                  15    
 Ser Ala Gln Leu Leu Phe Asn Lys Thr Lys Ser Val Glu Phe Thr Phe
              20                  25                  30        
 Cys Asn Asp Thr Val Val Ile Pro Cys Phe Val Thr Asn Met Glu Ala
          35                  40                  45            
 Gln Asn Thr Thr Glu Val Tyr Val Lys Trp Lys Phe Lys Gly Arg Asp
      50                  55                  60                
 Ile Tyr Thr Phe Asp Gly Ala Leu Asn Lys Ser Thr Val Pro Thr Asp
  65                  70                  75                  80
 Phe Ser Ser Ala Lys Ile Glu Val Ser Gln Leu Leu Lys Gly Asp Ala
                  85                  90                  95    
 Ser Leu Lys Met Asp Lys Ser Asp Ala Val Ser His Thr Gly Asn Tyr
             100                 105                 110        
 Thr Cys Glu Val Thr Glu Leu Thr Arg Glu Gly Glu Thr Ile Ile Glu
         115                 120                 125            
 Leu Lys Tyr Arg Val Val Ser Trp Phe Ser Pro Asn Glu Asn Ile Leu
     130                 135                 140                
 Ile Val Ile Phe Pro Ile Phe Ala Ile Leu Leu Phe Trp Gly Gln Phe
 145                 150                 155                 160
 Gly Ile Lys Thr Leu Lys Tyr Arg Ser Gly Gly Met Asp Glu Lys Thr
                 165                 170                 175    
 Ile Ala Leu Leu Val Ala Gly Leu Val Ile Thr Val Ile Val Ile Val
             180                 185                 190        
 Gly Ala Ile Leu Phe Val Pro Gly Glu Tyr Ser Leu Lys Asn Ala Thr
         195                 200                 205            
 Gly Leu Gly Leu Ile Val Thr Ser Thr Gly Ile Leu Ile Leu Leu His
     210                 215                 220                
 Tyr Tyr Val Phe Ser Thr Ala Ile Gly Leu Thr Ser Phe Val Ile Ala
 225                 230                 235                 240
 Ile Leu Val Ile Gln Val Ile Ala Tyr Ile Leu Ala Val Val Gly Leu
                 245                 250                 255    
 Ser Leu Cys Ile Ala Val Gln Phe Leu Val His Gly Lys Ile Glu Trp
             260                 265                 270        
 Lys Val His Ser His Gly Tyr Phe Tyr Val Asp Ile Ser Phe Gln Phe
         275                 280                 285            
 His Leu Gly Lys Tyr Gln Gly Val Gln Leu Arg Asp Cys Lys Asp Val
     290                 295                 300                
 Tyr Thr Asn Ala Trp Pro Ser Ser Asp Phe Arg Phe Glu Tyr Leu Ser
 305                 310                 315                 320
 Ser Ser Thr Ile Thr Trp Thr Ser Leu Tyr Glu Ile Cys Gly Leu Gly
                 325                 330                 335    
 Pro Lys Met Arg Lys Tyr Asn Trp Ser Asp Ser Arg Ile Ile Lys Glu
             340                 345                 350        
 Gly Arg Arg His Ile Gly Phe Leu Val Gly Ser Ser Ser Leu Arg Pro
         355                 360                 365            
 Glu Val Arg Lys Tyr Asn Trp Asn Asp Leu Arg Asn Gly Pro Ala Asn
     370                 375                 380                
 Cys Asp Ile Pro Trp Ile Gly Asp Leu Glu Leu Glu Ser Ile Leu Ser
 385                 390                 395                 400
 Thr Leu Leu Gly Lys Lys Arg Ser Tyr Leu Ala Gly Leu Lys Cys Pro
                 405                 410                 415    
 Val Trp Ala Arg Cys Leu His Thr Glu Lys Ser Gly Val Pro Arg Ser
             420                 425                 430        
 Gln Pro Gly Arg Tyr Glu Asp Pro Arg Lys Glu Ile Met Leu Arg Lys
         435                 440                 445            
 Gly Asp His Thr Ser Val Gln Pro Ala Pro Ala Pro Trp His Ala Leu
     450                 455                 460                
 Lys Thr Gln Gly Leu Asn Gln Gly Gln Arg His Ser Pro Pro Gly Cys
 465                 470                 475                 480
 Glu Asp Ser Lys Gly Ser Gln Leu His Glu Glu Gly Tyr Pro Glu Cys
                 485                 490                 495    
 Gln Ile Trp Ser Asn Ser Ala Arg Thr Leu Gln Asn Ser Val Trp Tyr
             500                 505                 510        
 Val Glu Glu Gly His Pro His Leu Ala Asp Val Gly Arg Lys Arg Ser
         515                 520                 525            
 Pro Leu Val Leu Ala Ala Arg Gly Asp Gly His Cys Gln Leu Arg Leu
     530                 535                 540                
 Ile Met Lys Ser Gly Phe Leu Glu Ser Ser Ala Glu His Trp Leu Phe
 545                 550                 555                 560
 Met Asp Lys Asp Arg
                 565



      <210> 1726
      <211> 326
      <212> PRT
      <213> Homo sapiens


      <400> 1726
 Met Val Val Ala Ala Pro Phe Ile Ile Trp Val Phe Leu Ala Ala Ala
   1               5                  10                  15    
 Thr Asn Val Asp Pro Ala Gly Asp Ser Val Ser Tyr Ser Ile His Ser
              20                  25                  30        
 Thr Ala Lys Val Val Leu Thr Arg Glu Asp Val His Ser Gln Val Ile
          35                  40                  45            
 Cys Glu Val Ala His Val Thr Leu Gln Gly Asp Pro Leu Arg Gly Thr
      50                  55                  60                
 Ala Asn Leu Ser Glu Thr Ile Arg Val Pro Pro Thr Leu Glu Val Thr
  65                  70                  75                  80
 Gln Gln Pro Val Arg Ala Glu Asn Gln Val Asn Val Thr Cys Gln Val
                  85                  90                  95    
 Arg Lys Phe Tyr Pro Gln Arg Leu Gln Leu Thr Trp Leu Glu Asn Gly
             100                 105                 110        
 Asn Val Ser Arg Thr Glu Thr Ala Ser Thr Leu Thr Glu Asn Lys Asp
         115                 120                 125            
 Gly Thr Tyr Asn Trp Met Ser Trp Leu Leu Val Asn Val Ser Ala His
     130                 135                 140                
 Arg Asp Asp Val Lys Leu Thr Cys Gln Val Glu His Asp Gly Gln Pro
 145                 150                 155                 160
 Ala Val Ser Lys Ser His Asp Leu Lys Val Ser Ala His Pro Lys Glu
                 165                 170                 175    
 Gln Gly Ser Asn Thr Ala Pro Gly His Leu Pro Ala His Arg Leu Leu
             180                 185                 190        
 Leu Leu Leu Cys Arg Val Leu Asp Ser Pro Glu Gln Ser Ser Phe Met
         195                 200                 205            
 Val Leu Ser Arg Gly His Gly Met Gly Leu Trp Gly Val Thr His Asp
     210                 215                 220                
 Thr Ser Leu Gly Cys Gly Lys His Ala Lys Ser Lys His Ile Arg Thr
 225                 230                 235                 240
 Pro Leu Leu His Arg Leu Gly Leu Ser Glu Ala Leu Leu Asn Ile Ser
                 245                 250                 255    
 Leu Ile Pro Thr Met Arg Thr Asn Gln Ala Ala Val Gly Lys Ile His
             260                 265                 270        
 Arg Arg Gly Ala Gly Trp Lys Val Phe Ala Pro Ser Ser Gln Ile Gly
         275                 280                 285            
 Phe Leu Ser Ser Leu Leu Thr Gln Ala Met Glu Leu Thr Pro Gly Ser
     290                 295                 300                
 Gln Arg Trp Ala Gln Gln Pro Leu Ser Ser Pro Leu Gly Pro Ala Val
 305                 310                 315                 320
 Met Pro Pro His Lys Ser
                 325    



      <210> 1727
      <211> 307
      <212> PRT
      <213> Homo sapiens


      <400> 1727
 Met Asp Val Val Asn Gln Leu Val Ala Gly Gly Gln Phe Arg Val Val
   1               5                  10                  15    
 Lys Glu Pro Leu Gly Phe Val Lys Val Leu Gln Trp Val Phe Ala Ile
              20                  25                  30        
 Phe Ala Phe Ala Thr Cys Gly Ser Tyr Ser Gly Glu Leu Gln Leu Ser
          35                  40                  45            
 Val Asp Cys Ala Asn Lys Thr Glu Ser Asp Leu Ser Ile Glu Val Glu
      50                  55                  60                
 Phe Glu Tyr Pro Phe Arg Leu His Gln Val Tyr Phe Asp Ala Pro Thr
  65                  70                  75                  80
 Cys Arg Gly Gly Thr Thr Lys Val Phe Leu Val Gly Asp Tyr Ser Ser
                  85                  90                  95    
 Ser Ala Glu Phe Phe Val Thr Val Ala Val Phe Ala Phe Leu Tyr Ser
             100                 105                 110        
 Met Gly Ala Leu Ala Thr Tyr Ile Phe Leu Gln Asn Lys Tyr Arg Glu
         115                 120                 125            
 Asn Asn Lys Gly Pro Met Leu Asp Phe Leu Ala Thr Ala Val Phe Ala
     130                 135                 140                
 Phe Met Trp Leu Val Ser Ser Ser Ala Trp Ala Lys Gly Leu Ser Asp
 145                 150                 155                 160
 Val Lys Met Ala Thr Asp Pro Glu Asn Ile Ile Lys Glu Met Pro Val
                 165                 170                 175    
 Cys Arg Gln Thr Gly Asn Thr Cys Lys Glu Leu Arg Asp Pro Val Thr
             180                 185                 190        
 Ser Gly Leu Asn Thr Ser Val Val Phe Gly Phe Leu Asn Leu Val Leu
         195                 200                 205            
 Trp Val Gly Asn Leu Trp Phe Val Phe Lys Glu Thr Gly Trp Ala Ala
     210                 215                 220                
 Pro Phe Leu Arg Ala Pro Pro Gly Ala Pro Glu Lys Gln Pro Ala Pro
 225                 230                 235                 240
 Gly Asp Ala Tyr Gly Asp Ala Gly Tyr Gly Gln Gly Pro Gly Gly Tyr
                 245                 250                 255    
 Gly Pro Gln Asp Ser Tyr Gly Pro Gln Gly Gly Tyr Gln Pro Asp Tyr
             260                 265                 270        
 Gly Gln Pro Ala Gly Ser Gly Gly Ser Gly Tyr Gly Pro Gln Gly Asp
         275                 280                 285            
 Tyr Gly Gln Gln Gly Tyr Gly Pro Gln Gly Ala Pro Thr Ser Phe Ser
     290                 295                 300                
 Asn Gln Met
 305        



      <210> 1728
      <211> 214
      <212> PRT
      <213> Homo sapiens


      <400> 1728
 Met Val Ser Asp Leu His Lys Leu Arg Glu Asn Val Trp Ala Leu Ala
   1               5                  10                  15    
 Gly Leu Leu Leu Ser Ser Ser Ala Ala Leu Ile His Ser Ser Leu Phe
              20                  25                  30        
 His Thr Met Thr Ser Lys Val Phe Trp Pro Ala Ile Arg Asn Asp Pro
          35                  40                  45            
 Phe Thr His Val Ser Leu Arg Lys Glu Ala Leu Leu Ser Arg Gly Asp
      50                  55                  60                
 Gln Leu Ser Pro Val Asp Val Lys Ser Glu Val Pro Val Gly Leu Glu
  65                  70                  75                  80
 Pro Ile Ser Pro Leu Asp Leu Arg Thr Asp Leu Arg Met Met Met Pro
                  85                  90                  95    
 Val Val Asp Pro Val Val Arg Glu Lys Gln Leu Gln Gln Glu Leu Leu
             100                 105                 110        
 Leu Ile Gln Gln Gln Gln Gln Ile Gln Lys Gln Leu Leu Ile Ala Glu
         115                 120                 125            
 Phe Gln Lys Gln His Glu Asn Leu Thr Arg Gln His Gln Ala Gln Leu
     130                 135                 140                
 Gln Glu His Ile Lys Leu Gln Gln Glu Leu Leu Ala Ile Lys Gln Gln
 145                 150                 155                 160
 Gln Glu Leu Leu Glu Lys Glu Gln Lys Leu Glu Gln Gln Arg Gln Glu
                 165                 170                 175    
 Gln Glu Val Glu Arg His Arg Arg Glu Gln Gln Leu Pro Pro Leu Arg
             180                 185                 190        
 Gly Lys Asp Arg Gly Arg Glu Ser Lys Arg His Gln Gly Lys Arg Trp
         195                 200                 205            
 Thr Leu Phe Pro His Arg
     210                



      <210> 1729
      <211> 779
      <212> PRT
      <213> Homo sapiens


      <400> 1729
 Met Ser Glu Ala Gly Gly Arg Gly Cys Gly Ser Pro Val Pro Gln Arg
   1               5                  10                  15    
 Ala Arg Trp Arg Leu Val Ala Ala Thr Ala Ala Phe Cys Leu Val Ser
              20                  25                  30        
 Ala Thr Ser Val Trp Thr Ala Gly Ala Glu Pro Met Ser Arg Glu Glu
          35                  40                  45            
 Lys Gln Lys Leu Gly Lys Ala Val Val Phe Ser Lys Asp Lys Gln Tyr
      50                  55                  60                
 Ser Ile Ile Lys Ser Lys Asn Ser Gly Leu Gly Ala Gly His Pro Glu
  65                  70                  75                  80
 Met Ala Leu Pro Pro Leu Ile Trp Val Thr Met Gly Lys Leu Pro Ser
                  85                  90                  95    
 Leu Pro Glu Pro Val Ser Ser Ser Leu Gln Asn Glu Asp Asn Asp Glu
             100                 105                 110        
 Gly Thr Ser Ser Glu Met Glu Val Leu Asn Lys Thr Lys Glu Phe Glu
         115                 120                 125            
 Asp Ala Val Arg Lys Val Leu Arg Asp Val Asn Leu Asp Asn Asp Val
     130                 135                 140                
 Val Val Ser Val Phe Glu Thr Asn Ile Arg Val Leu Gly Leu Asp Tyr
 145                 150                 155                 160
 Ala Ala Glu Gly Arg Thr Asp Ala Arg Pro Glu Leu Gly His Arg Ile
                 165                 170                 175    
 Ile Cys Val Glu Asp Ile Ile Glu Ala Glu Tyr Ala Arg Lys Ala Leu
             180                 185                 190        
 Asp Phe Leu Trp Glu Lys Arg Gln Arg Ser Ser Asn Leu Val Gly Val
         195                 200                 205            
 Thr Ile Asn Ile His Thr Gly Asp Trp Val Arg Lys Asp Ser Gly Val
     210                 215                 220                
 Gly Ala Gly Ile Asp Ser Tyr Tyr Glu Tyr Leu Leu Lys Ala Tyr Val
 225                 230                 235                 240
 Leu Leu Gly Asp Asp Ser Phe Leu Glu Arg Phe Asn Thr Val Leu Lys
                 245                 250                 255    
 Gly Asp Ile Arg Pro Ala Ile Glu Thr His Glu Met Leu Tyr Gln Val
             260                 265                 270        
 Ile Lys Lys His Asn Phe Leu Pro Glu Ala Thr Gly Asp Pro Tyr Tyr
         275                 280                 285            
 Leu Glu Val Gly Lys Thr Leu Ile Glu Asn Leu Asn Lys Tyr Ala Arg
     290                 295                 300                
 Val Pro Cys Gly Phe Ala Ala Met Lys Asp Val Arg Thr Gly Ser His
 305                 310                 315                 320
 Glu Asp Arg Met Asp Ser Phe Phe Leu Ala Glu Met Phe Lys Tyr Leu
                 325                 330                 335    
 Tyr Leu Leu Phe Ala Asp Lys Glu Asp Ile Ile Phe Asp Ile Glu Asp
             340                 345                 350        
 Tyr Ile Phe Thr Thr Glu Ala His Leu Leu Pro Leu Trp Leu Ser Thr
         355                 360                 365            
 Thr Asn Gln Ser Ile Ser Lys Lys Asn Thr Thr Ser Glu Tyr Thr Glu
     370                 375                 380                
 Leu Asp Asp Ser Asn Phe Asp Trp Thr Cys Pro Asn Thr Gln Ile Leu
 385                 390                 395                 400
 Phe Pro Asn Asp Pro Leu Tyr Ala Gln Ser Ile Arg Glu Pro Leu Lys
                 405                 410                 415    
 Asn Val Val Asp Lys Ser Cys Pro Arg Gly Ile Ile Arg Val Glu Glu
             420                 425                 430        
 Ser Phe Arg Ser Gly Ala Lys Pro Pro Leu Arg Ala Arg Asp Phe Met
         435                 440                 445            
 Ala Thr Asn Pro Glu His Leu Glu Ile Leu Lys Lys Met Gly Ala Ala
     450                 455                 460                
 Ser Ser Ile Asp Ala Glu Asp Gly Leu Arg Phe Met Gln Glu Met Ile
 465                 470                 475                 480
 Glu Leu Ser Ser Gln Gln Gln Lys Glu Gln Gln Leu Pro Pro Arg Ala
                 485                 490                 495    
 Val Gln Ile Val Ser His Pro Phe Phe Gly Arg Val Val Leu Thr Ala
             500                 505                 510        
 Gly Pro Ala Gln Phe Gly Leu Asp Leu Ser Lys His Lys Glu Thr Arg
         515                 520                 525            
 Gly Phe Val Ala Ser Ser Lys Pro Ser Asn Gly Cys Ser Glu Leu Thr
     530                 535                 540                
 Asn Pro Glu Ala Val Met Gly Lys Ile Ala Leu Ile Gln Arg Gly Gln
 545                 550                 555                 560
 Cys Met Phe Ala Glu Lys Ala Arg Asn Ile Gln Asn Ala Gly Ala Ile
                 565                 570                 575    
 Gly Gly Ile Val Ile Asp Asp Asn Glu Gly Ser Ser Ser Asp Thr Ala
             580                 585                 590        
 Pro Leu Phe Gln Met Ala Gly Asp Gly Lys Asp Thr Asp Asp Ile Lys
         595                 600                 605            
 Ile Pro Met Leu Phe Leu Phe Ser Lys Glu Gly Ser Ile Ile Leu Asp
     610                 615                 620                
 Ala Ile Arg Glu Tyr Glu Glu Val Glu Val Leu Leu Ser Asp Lys Ala
 625                 630                 635                 640
 Lys Asp Arg Asp Pro Glu Met Glu Asn Glu Glu Gln Pro Ser Ser Glu
                 645                 650                 655    
 Asn Asp Ser Gln Asn Gln Ser Gly Glu Gln Ile Ser Ser Ser Ser Gln
             660                 665                 670        
 Glu Val Asp Leu Val Asp Gln Glu Ser Ser Glu Glu Asn Ser Leu Asn
         675                 680                 685            
 Ser His Pro Glu Ser Leu Ser Leu Ala Asp Met Asp Asn Ala Ala Ser
     690                 695                 700                
 Ile Ser Pro Ser Glu Gln Thr Ser Asn Pro Thr Glu Asn His Glu Thr
 705                 710                 715                 720
 Thr Asn Leu Asn Gly Glu Cys Thr Asp Leu Asp Asn Gln Leu Gln Glu
                 725                 730                 735    
 Gln Ser Glu Thr Glu Glu Asp Ser Asn Pro Asn Val Ser Trp Gly Lys
             740                 745                 750        
 Lys Val Gln Pro Ile Asp Ser Ile Leu Ala Asp Trp Asn Glu Asp Ile
         755                 760                 765            
 Glu Ala Phe Glu Met Met Glu Lys Asp Glu Leu
     770                 775                



      <210> 1730
      <211> 914
      <212> PRT
      <213> Homo sapiens


      <400> 1730
 Met Val Gln Pro Leu Trp Lys Ala Val Trp Gln Phe Leu Lys Lys Leu
   1               5                  10                  15    
 Ile Thr Glu Val Phe Ser Ser Lys Lys Arg Asn Cys Ala Trp Gly Ala
              20                  25                  30        
 Tyr Ala Phe Pro Leu Ala Leu Phe Ile Pro Asp Ile Glu Gln Ala Arg
          35                  40                  45            
 Val Gln His Ser Val Thr Val Pro Val Leu Ser Leu Pro Ser Leu Gln
      50                  55                  60                
 Pro Phe Pro Ser Leu Pro Ser Asn Ser Ser Leu Pro Phe Pro Pro Thr
  65                  70                  75                  80
 Val Pro Phe Pro Ser Leu Gln Pro Phe Pro Ser Ser Asn Arg Cys Leu
                  85                  90                  95    
 Pro Asp Glu Asp Arg Thr Asp Thr Glu Ile Leu Gly Gly Ala Val Glu
             100                 105                 110        
 Ser Trp Gly Phe Leu Val Trp Asp Cys Pro Arg Arg Thr Tyr Ser Phe
         115                 120                 125            
 Pro Leu Ala Ser Phe Ile Pro Glu Val Gly Met Asp Pro Ser Trp His
     130                 135                 140                
 Gly Gln Phe Tyr His Leu Leu Thr Leu Arg Val Lys Ser Leu Gln Gln
 145                 150                 155                 160
 Gly Ser Pro Glu Pro Pro Glu Pro Ser Glu Trp Arg Gly Glu Asn Arg
                 165                 170                 175    
 Trp Arg Gln Thr Ser Glu Leu Gly Ser Thr Glu Ala Ala Ala Ala Ala
             180                 185                 190        
 Gln Val Gln Val Ser Gly Leu Gly Glu Cys Val Thr Gly Pro Ile Ser
         195                 200                 205            
 Asn Pro Glu Glu Gly Gln Glu Ser Pro Asp Tyr Ser Val Leu Gly Arg
     210                 215                 220                
 Thr Gln Gly Ser Leu Cys Ser Ser Pro Phe Asp Leu Ala Asp Asp Lys
 225                 230                 235                 240
 Lys Arg Arg Pro Val Leu Pro Ala Arg Ile Ala His Ser Leu Lys Gln
                 245                 250                 255    
 Gly Trp Asn Val Val Lys Val Pro Leu Pro Gly Ser Ser Asp Pro Arg
             260                 265                 270        
 Ser Gln Pro Ile Asn Leu Asn His Tyr Ala Thr Lys Lys Ser Val Ala
         275                 280                 285            
 Glu Ser Met Leu Asp Val Ala Leu Phe Met Ser Asn Ala Met Arg Leu
     290                 295                 300                
 Lys Ala Val Leu Glu Gln Gly Pro Ser Ser His Tyr Tyr Thr Thr Leu
 305                 310                 315                 320
 Val Thr Leu Ile Ser Leu Ser Leu Leu Leu Gln Val Val Ile Gly Val
                 325                 330                 335    
 Leu Leu Val Val Ile Val Leu Pro Asn Gly Ile Asp Asp Ser Ser Trp
             340                 345                 350        
 Glu Val Asp Val Glu Val Thr Glu Glu Asp Asp Ala Val Arg Val Leu
         355                 360                 365            
 Gly Thr Asp Val Gly Arg Leu Gly Pro Leu Gln Cys His Leu Asn Ile
     370                 375                 380                
 His Val Leu Thr Ala Ile Val Ser Asp Asp Asp Val Glu Val Trp Val
 385                 390                 395                 400
 Thr Gly Asp Leu Glu Gln Val Phe His Val Phe Asp Glu Leu Leu Tyr
                 405                 410                 415    
 Pro Ala Cys Leu Val Leu His Tyr Pro Arg Gly Ser Gly Arg Arg Arg
             420                 425                 430        
 Lys His Arg Gln Gly Lys Asp Glu Arg Met Ser Ala Ser Thr Pro Ser
         435                 440                 445            
 Ser Gln Ser Leu Ala Pro Gly Glu Pro Phe Thr Leu Pro Pro Ala Pro
     450                 455                 460                
 Leu Val Glu Leu Leu Gln Glu Asp Ser Arg Asp Leu Gln Ser Phe Leu
 465                 470                 475                 480
 Leu Trp Lys Gln Gln Val Ala Arg Cys Val Thr Ala Gln Ile Asp Pro
                 485                 490                 495    
 Val Ser Pro Gln Gly Leu Glu Val Glu Ile Pro Gly Thr Glu Gly Leu
             500                 505                 510        
 Val Pro Val Tyr Tyr Arg Val Lys His Ser Leu Glu Val Trp Lys Arg
         515                 520                 525            
 Glu Glu Glu Gly Gly Thr Glu Lys Thr Gly Ser Thr Arg Gly Gly Glu
     530                 535                 540                
 Cys Glu Thr Arg Lys Glu Asn Gln Glu Val Arg Glu Lys Gly Arg Lys
 545                 550                 555                 560
 Thr Gly Gly Met Lys Val Pro Pro Glu Leu Leu Asp Arg Ala Ala Thr
                 565                 570                 575    
 Pro Val Phe Lys His Met Gln Val Gly Thr Ala Pro Glu Leu Gln Gly
             580                 585                 590        
 Gly Asp Ala Ser Glu Pro Gln Leu Gln Glu Asp Glu His Pro Thr Pro
         595                 600                 605            
 Ala Pro Asp Pro Gln Leu Gln Glu Asp Glu His Pro Met Pro Val Pro
     610                 615                 620                
 Ala Pro Gln Leu Gln Glu Asp Glu His Pro Met Pro Ala Pro Ala Pro
 625                 630                 635                 640
 Gln Leu Trp Glu Asp Glu His Pro Met Pro Ala Pro Ala Pro Gln Leu
                 645                 650                 655    
 Arg Glu Asp Glu His Pro Met Pro Ala Pro Ala Pro Gln Leu Gln Glu
             660                 665                 670        
 Asp Glu His Pro Thr Pro Ala Pro Asp Pro Gln Phe Gln Glu Asp Glu
         675                 680                 685            
 His Pro Met Pro Val Pro Ala Pro Gln Leu Gln Glu Asp Glu His Pro
     690                 695                 700                
 Met Pro Ala Pro Ala Pro Gln Leu Arg Glu Asp Glu His Pro Met Pro
 705                 710                 715                 720
 Ala Pro Ala Pro Gln Leu Gln Glu Asp Glu His Pro Met Pro Ile Pro
                 725                 730                 735    
 Ala Pro Gln Phe Gln Glu Asp Glu His Pro Met Pro Val Pro Ala Pro
             740                 745                 750        
 Gln Phe Gln Glu Asp Glu His Pro Met Pro Val Pro Ala Pro Gln Leu
         755                 760                 765            
 Gln Glu Asp Glu His Pro Met Pro Ala Pro Ala Pro Gln Leu Arg Glu
     770                 775                 780                
 Asp Glu His Pro Met Pro Ala Pro Ala Pro Gln Leu Gln Glu Asp Glu
 785                 790                 795                 800
 His Pro Met Pro Ala Pro Ala Pro Gln Leu Arg Glu Arg Asp His Pro
                 805                 810                 815    
 Met Pro Ile Pro Ala Pro Gln Leu Arg Glu Ala Gly Gln Lys Gly Ala
             820                 825                 830        
 Gly Ala Pro Leu Thr Val Arg Val Arg Pro Thr Leu Ser His Ser Gln
         835                 840                 845            
 Pro Ser Thr Gln His Phe Phe Gln Glu Pro Gly Ala Asp Val His Pro
     850                 855                 860                
 Met Ala Trp Pro Trp Gly Gln Gly Leu Leu Trp Pro Cys Thr His Thr
 865                 870                 875                 880
 His Ile Leu Ser Leu Asp Leu Pro Cys Arg Lys Gly Ala Gly Val His
                 885                 890                 895    
 Ser Pro Gly Asn Gly Asp Asn Gly Cys Asp Arg Ile Ala Glu Arg Thr
             900                 905                 910        
 Gly Asn
        



      <210> 1731
      <211> 411
      <212> PRT
      <213> Homo sapiens


      <400> 1731
 Met Gly Thr Cys Asp Ile Val Thr Glu Ala Asn Ile Ser Ser Gly Pro
   1               5                  10                  15    
 Glu Ser Asn Thr Thr Gly Ile Thr Ala Phe Ser Met Pro Ser Trp Gln
              20                  25                  30        
 Leu Ala Leu Trp Ala Thr Ala Tyr Leu Ala Leu Val Leu Val Ala Val
          35                  40                  45            
 Thr Gly Asn Ala Ile Val Ile Trp Ile Ile Leu Ala His Arg Arg Met
      50                  55                  60                
 Arg Thr Val Thr Asn Tyr Phe Ile Val Asn Leu Ala Leu Ala Asp Leu
  65                  70                  75                  80
 Cys Met Ala Ala Phe Asn Ala Ala Phe Asn Phe Val Tyr Ala Ser His
                  85                  90                  95    
 Asn Ile Trp Tyr Phe Gly Arg Ala Phe Cys Tyr Phe Gln Asn Leu Phe
             100                 105                 110        
 Pro Ile Thr Ala Met Tyr Met Ala Ile Val His Pro Phe Gln Pro Arg
         115                 120                 125            
 Leu Ser Ala Pro Ser Thr Lys Ala Val Ile Ala Gly Ile Trp Leu Val
     130                 135                 140                
 Ala Leu Ala Leu Ala Ser Pro Gln Cys Phe Tyr Ser Thr Val Thr Met
 145                 150                 155                 160
 Asp Gln Gly Ala Thr Lys Cys Val Val Ala Trp Pro Glu Asp Ser Gly
                 165                 170                 175    
 Gly Lys Thr Leu Leu Leu Tyr His Leu Val Val Ile Ala Leu Ile Tyr
             180                 185                 190        
 Phe Leu Pro Leu Ala Val Met Phe Val Ala Tyr Ser Val Ile Gly Leu
         195                 200                 205            
 Thr Leu Trp Arg Arg Ala Val Pro Gly His Gln Ala His Gly Ala Asn
     210                 215                 220                
 Leu Arg His Leu Gln Ala Lys Lys Lys Phe Val Lys Thr Met Val Leu
 225                 230                 235                 240
 Val Val Leu Thr Phe Ala Ile Cys Trp Leu Pro Tyr His Leu Tyr Phe
                 245                 250                 255    
 Ile Leu Gly Ser Phe Gln Glu Asp Ile Tyr Cys His Lys Phe Ile Gln
             260                 265                 270        
 Gln Val Tyr Leu Ala Leu Phe Trp Leu Ala Met Ser Ser Thr Met Tyr
         275                 280                 285            
 Asn Pro Ile Ile Tyr Cys Cys Leu Asn His Arg Phe Arg Ser Gly Phe
     290                 295                 300                
 Arg Leu Ala Phe Arg Cys Cys Pro Trp Val Thr Pro Thr Lys Glu Asp
 305                 310                 315                 320
 Lys Leu Glu Leu Thr Pro Thr Thr Ser Leu Ser Thr Arg Gly Asp Asn
                 325                 330                 335    
 Leu Asp Gln Leu Ile Leu Ala Val Ala Glu Asp Gly Leu Ile Pro Gly
             340                 345                 350        
 Gly Leu Arg Gln Arg Ala Asp Thr Ala Ile Ser Asp Met Pro Pro Phe
         355                 360                 365            
 His Pro Arg Leu Lys Leu Arg Glu Glu Glu Leu Gln Lys Arg Lys Met
     370                 375                 380                
 Met Gly Val Gly Asp Ala Lys Lys Ala Lys Thr Trp Lys Pro Tyr Ile
 385                 390                 395                 400
 Leu Pro Met Gly Val Leu Ser Lys Glu Ile Asn
                 405                 410    



      <210> 1732
      <211> 338
      <212> PRT
      <213> Homo sapiens


      <400> 1732
 Met Ser Ala Pro Thr Cys Leu Ala His Leu Pro Pro Cys Phe Leu Leu
   1               5                  10                  15    
 Leu Ala Leu Val Leu Val Pro Ser Asp Ala Ser Gly Gln Ser Ser Arg
              20                  25                  30        
 Asn Asp Trp Gln Val Leu Gln Pro Glu Gly Pro Met Leu Val Ala Glu
          35                  40                  45            
 Gly Glu Thr Leu Leu Leu Arg Cys Met Val Val Gly Ser Cys Thr Asp
      50                  55                  60                
 Gly Met Ile Lys Trp Val Lys Val Ser Thr Gln Asp Gln Gln Glu Ile
  65                  70                  75                  80
 Tyr Asn Phe Lys Arg Gly Ser Phe Pro Gly Val Met Pro Met Ile Gln
                  85                  90                  95    
 Arg Thr Ser Glu Pro Leu Asn Cys Asp Tyr Ser Ile Tyr Ile His Asn
             100                 105                 110        
 Val Thr Arg Glu His Thr Gly Thr Tyr His Cys Val Arg Phe Asp Gly
         115                 120                 125            
 Leu Ser Glu His Ser Glu Met Lys Ser Asp Glu Gly Thr Ser Val Leu
     130                 135                 140                
 Val Lys Gly Ala Gly Asp Pro Glu Pro Asp Leu Trp Ile Ile Gln Pro
 145                 150                 155                 160
 Gln Glu Leu Val Leu Gly Thr Thr Gly Asp Thr Val Phe Leu Asn Cys
                 165                 170                 175    
 Thr Val Leu Gly Asp Gly Pro Pro Gly Pro Ile Arg Trp Phe Gln Gly
             180                 185                 190        
 Ala Gly Leu Ser Arg Glu Ala Ile Tyr Asn Phe Gly Gly Ile Ser His
         195                 200                 205            
 Pro Lys Glu Thr Ala Val Gln Ala Ser Asn Asn Asp Phe Ser Ile Leu
     210                 215                 220                
 Leu Gln Asn Val Ser Ser Glu Asp Ala Gly Thr Tyr Tyr Cys Val Lys
 225                 230                 235                 240
 Phe Gln Arg Lys Pro Asn Arg Gln Tyr Leu Ser Gly Gln Gly Thr Ser
                 245                 250                 255    
 Leu Lys Val Lys Ala Lys Ser Thr Ser Ser Lys Glu Ala Glu Phe Thr
             260                 265                 270        
 Ser Glu Pro Ala Thr Glu Met Ser Pro Thr Gly Leu Leu Val Val Phe
         275                 280                 285            
 Ala Pro Val Val Leu Gly Leu Lys Ala Ile Thr Leu Ala Ala Leu Leu
     290                 295                 300                
 Leu Ala Leu Ala Thr Ser Arg Arg Ser Pro Gly Gln Glu Asp Val Lys
 305                 310                 315                 320
 Thr Thr Gly Pro Ala Gly Ala Met Asn Thr Leu Ala Trp Ser Lys Gly
                 325                 330                 335    
 Gln Glu
        



      <210> 1733
      <211> 190
      <212> PRT
      <213> Homo sapiens


      <400> 1733
 Met Gly Pro Pro Ser Leu Val Leu Cys Leu Leu Ser Ala Thr Val Phe
   1               5                  10                  15    
 Ser Leu Leu Gly Gly Ser Ser Ala Phe Leu Ser His His Arg Leu Lys
              20                  25                  30        
 Gly Arg Phe Gln Arg Asp Arg Arg Asn Ile Arg Pro Asn Ile Ile Leu
          35                  40                  45            
 Val Leu Thr Asp Asp Gln Asp Val Glu Leu Val Gly Asp Ile Pro Val
      50                  55                  60                
 Ser Gln Trp Pro Ser Glu Thr Asn Gly Leu Leu Leu Asp Phe Arg Ser
  65                  70                  75                  80
 Lys Arg Ile Arg Gly Lys His Met Glu Pro Leu Ile Thr Arg Gly Glu
                  85                  90                  95    
 Lys Thr Cys Gly Cys Arg Leu Ser Gln Glu Glu Glu Arg Leu Ile Arg
             100                 105                 110        
 Thr His Thr Gly Val Gln Leu Ala Lys His Ile Pro Val Lys Arg Val
         115                 120                 125            
 Ala Gln Gly Gln Glu Arg Lys Gln Gly Asp Gln Val Val Phe Ala Ala
     130                 135                 140                
 Val Gln Val Gly Asp Ala Gly Gly Thr Glu Gln Asp Gly Ala Leu Gln
 145                 150                 155                 160
 Ser Glu Arg Glu Ser Gln Ser Cys Leu Leu Asp Ile Cys Leu Ile Asp
                 165                 170                 175    
 Phe Gly Phe Arg Asn Arg Phe Gly Ala Leu Ala Phe Arg Ser
             180                 185                 190



      <210> 1734
      <211> 492
      <212> PRT
      <213> Homo sapiens


      <400> 1734
 Met Ala Gly Leu Trp Leu Gly Leu Val Trp Gln Lys Leu Leu Leu Trp
   1               5                  10                  15    
 Gly Ala Ala Ser Ala Val Ser Leu Ala Gly Ala Ser Leu Val Leu Ser
              20                  25                  30        
 Leu Leu Gln Arg Val Ala Ser Tyr Ala Arg Lys Trp Gln Gln Met Arg
          35                  40                  45            
 Pro Ile Pro Thr Val Ala Arg Ala Tyr Pro Leu Val Gly His Ala Leu
      50                  55                  60                
 Leu Met Lys Pro Asp Gly Arg Glu Phe Phe Gln Gln Ile Ile Glu Tyr
  65                  70                  75                  80
 Thr Glu Glu Tyr Arg His Met Pro Leu Leu Lys Leu Trp Val Gly Pro
                  85                  90                  95    
 Val Pro Met Val Ala Leu Tyr Asn Ala Glu Asn Val Glu Asn Pro Gly
             100                 105                 110        
 Ser Glu Lys Arg Ala Arg Arg Ala Asp Arg Ile Ser Ala Ala Val Gly
         115                 120                 125            
 Leu Val Leu Ile Glu Val Gly Val Val Asp Ala Asp Gly Asp Leu Ser
     130                 135                 140                
 Arg Val Gly Asp Leu Ser Lys Lys Pro Asp Ile Phe Phe Val Thr Thr
 145                 150                 155                 160
 Tyr Phe Ile Ser Ser Thr Gly Asn Lys Trp Arg Ser Arg Arg Lys Met
                 165                 170                 175    
 Leu Thr Pro Thr Phe His Phe Thr Ile Leu Glu Asp Phe Leu Asp Ile
             180                 185                 190        
 Met Asn Glu Gln Ala Asn Ile Leu Val Lys Lys Leu Glu Lys His Ile
         195                 200                 205            
 Asn Gln Glu Ala Phe Asn Cys Phe Phe Tyr Ile Thr Leu Cys Ala Leu
     210                 215                 220                
 Asp Ile Ile Cys Gly Asn His Thr Pro Leu Gly Arg Gln Met Gly Gly
 225                 230                 235                 240
 Arg Glu Arg Val Thr Gly Ser Ser Ala Arg Phe Tyr Asp Arg Thr Gly
                 245                 250                 255    
 Leu Leu Arg Ser Ser Ser His Ala Gln Gly Cys Glu Trp Gly Arg His
             260                 265                 270        
 Gly Ala Thr Ala Gln Gly Gly Glu Gly Lys Glu Glu Gln Glu Gln Gly
         275                 280                 285            
 Val Glu Val Asp Arg Thr Arg Glu Glu Glu Thr Ala Met Gly Lys Asn
     290                 295                 300                
 Ile Gly Ala Gln Ser Asn Asp Asp Ser Glu Tyr Val Arg Ala Val Tyr
 305                 310                 315                 320
 Arg Met Ser Glu Met Ile Phe Arg Arg Ile Lys Met Pro Trp Leu Trp
                 325                 330                 335    
 Leu Asp Leu Trp Tyr Leu Met Phe Lys Glu Gly Trp Glu His Lys Lys
             340                 345                 350        
 Ser Leu Gln Ile Leu His Thr Phe Thr Asn Ser Val Ile Ala Glu Arg
         355                 360                 365            
 Ala Asn Glu Met Asn Ala Asn Glu Asp Cys Arg Gly Asp Gly Arg Gly
     370                 375                 380                
 Ser Ala Pro Ser Lys Asn Lys Arg Arg Ala Phe Leu Asp Leu Leu Leu
 385                 390                 395                 400
 Ser Val Thr Asp Asp Glu Gly Asn Arg Leu Ser His Glu Asp Ile Arg
                 405                 410                 415    
 Glu Glu Val Asp Thr Phe Met Phe Glu Ala Gly Ala Gly Cys Asn Cys
             420                 425                 430        
 Pro Gly Ser Ser Cys Glu Leu Lys Val Gly Val Leu Pro Cys Ser Thr
         435                 440                 445            
 Ser Val Pro Arg Cys Phe Thr Phe Ala Leu Ser Cys Phe Leu Gln Leu
     450                 455                 460                
 Ala Asp Glu Met Lys Ser Glu Val Gln Gln Thr Pro Leu Met His Leu
 465                 470                 475                 480
 Asp Gln Ala Ser Ala His Lys Phe Lys Glu Ser Tyr
                 485                 490        



      <210> 1735
      <211> 1071
      <212> PRT
      <213> Homo sapiens


      <400> 1735
 Met Asp Lys Pro Arg Pro Gly Lys Thr Thr Phe Val Ile Met Val Ser
   1               5                  10                  15    
 Pro Leu Pro Gly Ile Tyr Ser Cys Leu Val Phe Ile Ser Leu Thr Leu
              20                  25                  30        
 Gly Trp Ala Ser Leu Gly Tyr Ile Ser Met Ala Leu Trp Gln Asp Leu
          35                  40                  45            
 Asn Arg Leu Val Met Thr Leu Asp Val Pro Ile Ala Thr Phe Lys Asn
      50                  55                  60                
 Val Ile Lys Gly Leu Arg Glu Asn Val Arg Lys His Arg Lys Pro Asp
  65                  70                  75                  80
 Phe Glu Ser Cys Arg Leu Ser Phe Phe Leu Ile Gln Ser Val Tyr Asp
                  85                  90                  95    
 Ile Ala Val Arg Leu Gln Pro Leu Pro Arg Leu Arg Phe Tyr Leu Arg
             100                 105                 110        
 Leu Glu Arg Leu Gln Leu Thr Ser Ala Phe Gly Ala Leu Cys Ser Asp
         115                 120                 125            
 Thr Phe Gln Pro Pro Phe Cys Ala Ser Phe Pro Arg Lys Asn Arg Arg
     130                 135                 140                
 Val Thr Ile Leu Ser Asn Pro Leu Phe Arg Phe Thr Asp Lys Gly Glu
 145                 150                 155                 160
 Ala Leu Lys Glu Phe Ser Leu Ile Leu Thr Leu Ser Leu Leu Glu Thr
                 165                 170                 175    
 Lys Leu Met Lys Glu Leu Arg Lys Ala Leu Gln Gln Leu Gln Glu Leu
             180                 185                 190        
 Gln Asn Lys Ser Gln Gln Leu Arg Ala Trp Glu Ala Glu Lys Tyr Asn
         195                 200                 205            
 Glu Ile Arg Thr Gln Glu Gln Asn Val Gln His Leu Asn His Ser Leu
     210                 215                 220                
 Ser His Lys Glu Gln Leu Leu Gln Glu Phe Arg Glu Leu Leu Gln Tyr
 225                 230                 235                 240
 Arg Asp Asn Ser Asp Lys Thr Leu Glu Ala Asn Glu Thr Leu Leu Glu
                 245                 250                 255    
 Lys Leu Arg Gln Arg Ile His Asp Lys Ala Val Ala Leu Glu His Ser
             260                 265                 270        
 Gln Glu Met Glu Ser Leu Arg Glu Ala Leu Leu Ser Ser Arg Ser His
         275                 280                 285            
 Leu Gln Glu Leu Glu Glu Glu Leu Glu His Gln Lys Val Glu Arg Gln
     290                 295                 300                
 Gln Leu Leu Glu Asp Leu Arg Glu Lys Gln Gln Glu Val Leu His Phe
 305                 310                 315                 320
 Arg Glu Glu Arg Leu Ser Leu Gln Glu Asn Asp Ser Arg Leu Lys His
                 325                 330                 335    
 Lys Leu Val Leu Leu Gln Gln Gln Cys Glu Glu Lys Gln Gln Leu Phe
             340                 345                 350        
 Glu Ser Leu Gln Ser Glu Leu Gln Ile Tyr Glu Ala Leu Tyr Gly Asn
         355                 360                 365            
 Ser Lys Lys Gly Leu Lys Ala Tyr Ser Leu Asp Val Cys His Gln Ile
     370                 375                 380                
 Pro Leu Ser Ser Asp Leu Ser His Leu Val Ala Glu Asn Phe Pro Ala
 385                 390                 395                 400
 Ser Ala Asp Pro Gly Asn Lys Gln Leu Leu Leu Gln Gly Leu Gly Leu
                 405                 410                 415    
 Asp Thr Ser Pro Val Met Lys Ala Pro Pro Lys Leu Glu Gly Asp Ala
             420                 425                 430        
 Thr Asp Gly Ser Phe Ala Asn Lys His Gly Arg His Val Ile Gly His
         435                 440                 445            
 Ile Asp Asp Tyr Ser Ala Leu Arg Gln Gln Ile Val Glu Gly Lys Leu
     450                 455                 460                
 Leu Val Lys Lys Ile Val Ser Leu Val Arg Ser Ala Cys Ser Phe Pro
 465                 470                 475                 480
 Gly Leu Glu Ala Gln Gly Thr Gly Val Leu Gly Ser Lys Gly Ile His
                 485                 490                 495    
 Glu Leu Trp Ser Ser Thr Ser Ala Leu His His Ala Leu Glu Glu Ser
             500                 505                 510        
 Ala Ser Leu Leu Thr Met Phe Trp Arg Val Ala Leu Pro Ser Thr His
         515                 520                 525            
 Ile Pro Val Leu Pro Gly Lys Val Leu Glu Val Phe Lys Ala Val Lys
     530                 535                 540                
 Glu Glu Ile Gln Phe Arg Arg Val Glu Lys Ile Val Glu Ser Phe Glu
 545                 550                 555                 560
 Leu Glu Arg Ala Thr Lys His Arg Val Leu Tyr Val Phe Cys Leu Arg
                 565                 570                 575    
 Glu Ser Thr Glu Arg Glu Leu Leu Glu Leu Arg Thr Lys Val Ser Lys
             580                 585                 590        
 Gln Glu Trp Leu Leu Gln Ser Thr Ala Glu His Leu Lys Ile Ala Asn
         595                 600                 605            
 Gln Gln Lys Glu Ser Met Glu Gln Phe Ile Val Ser Gln Arg Glu Ile
     610                 615                 620                
 Pro Lys Gly Ser Ala Met Tyr Ser Ser Leu Val Thr Leu Ala Phe Gln
 625                 630                 635                 640
 Glu Pro Cys Lys Lys Arg Ser His Arg Lys Ser Leu Lys Gln Gln Glu
                 645                 650                 655    
 Arg Leu Ala Cys Pro Pro Phe Ile Leu Thr Asn Ile Asn Ser Ile Asn
             660                 665                 670        
 Asn Ile Glu Ala Asn Met Thr Ser Thr Asn Gly Pro Ser Phe Gln Leu
         675                 680                 685            
 Arg Leu Gln Phe His Tyr Asn Leu Tyr Ala Pro Ile Gly Pro Ala Cys
     690                 695                 700                
 Gly Asn Glu Val Ser Arg Val Ser Lys Gly His Leu Glu Gln Glu Tyr
 705                 710                 715                 720
 His Pro Tyr Leu Glu Gly Gln Val Glu Ala Tyr His Leu His Ser Lys
                 725                 730                 735    
 Val Leu Thr Val His Val Lys Ser Gln Ala Lys Asp Arg Ser Ser Ser
             740                 745                 750        
 Pro Ala Met Glu Gln Ser Arg Ile Glu Asn Asp Phe Asp Glu Leu Thr
         755                 760                 765            
 Glu Val Gly Phe Arg Lys Ser Val Ile Thr Asn Phe Ser Glu Leu Lys
     770                 775                 780                
 Glu Asp Val Arg Thr His Arg Lys Glu Ala Lys Asn Leu Glu Lys Arg
 785                 790                 795                 800
 Leu Asp Glu Trp Leu Thr Arg Met Asn Ser Val Glu Lys Thr Leu Asn
                 805                 810                 815    
 Asp Leu Met Glu Leu Lys Thr Met Ala Arg Lys Leu Arg Asp Ala Cys
             820                 825                 830        
 Thr Ser Phe Ser Ser Gln Phe Asp Gln Val Gln Glu Thr Gly Asp Cys
         835                 840                 845            
 Ala Ala Lys Gln Ala Asp Leu Lys Glu Ile Gln Met Lys Ala Glu Ser
     850                 855                 860                
 Ser Glu Thr Trp Gly Thr Ile Phe Pro Asn Thr Lys Ala Arg Leu Pro
 865                 870                 875                 880
 Ala Ser Leu Asn Arg His Arg Asn Ser Met Asp Ile Val Gln Gly Gln
                 885                 890                 895    
 Met Thr Lys Ser Gln Met Thr Arg Asp Thr Glu Ser Lys Leu Gly Gly
             900                 905                 910        
 Leu Thr Asp Thr Ala Cys Ala Pro Pro Ala Leu Arg Met Phe Ile Ser
         915                 920                 925            
 Ala Phe Ser Leu Asp Lys Gly Pro Ala Asp Thr Thr Met Leu Thr Phe
     930                 935                 940                
 Val Ala Glu Glu Glu Gln Glu Pro Val His Gln Glu Ala Asp Phe Thr
 945                 950                 955                 960
 Leu Thr Lys Asp Thr Ala Ile Val Gly Asn Lys Asp Pro Pro Ser Ile
                 965                 970                 975    
 Cys Ala Thr Val Pro Gly Lys Thr Phe Leu Asn Ile Thr Pro Ala Glu
             980                 985                 990        
 Val Gly Val Leu Val Gly Lys Asp Trp Ser Ser Phe Val Met Asn Gly
         995                1000                1005            
 Leu Thr Leu Gly Gly Gln Lys Tyr Thr Val Val Leu Asp Ser Leu Leu
    1010                1015                1020                
 Gln Asp Gly Glu Leu Thr Thr Asp Leu Cys Met Lys Ser Ile Gly Gly
1025                1030                1035                1040
 Ala Pro Thr Phe Asn Val Ile Val Thr Met Thr Ala Lys Thr Leu Gly
                1045                1050                1055    
 Leu Leu Met Gly Lys Glu Gly Ile His Gly Asn Phe Ile Asn Lys
            1060                1065                1070    



      <210> 1736
      <211> 294
      <212> PRT
      <213> Homo sapiens


      <400> 1736
 Met Thr Ile Ala Thr Ser Tyr Leu Gly Val Leu Ala Ala Leu Ala Phe
   1               5                  10                  15    
 Leu Gly Ala Val Leu Thr Pro Leu Phe His Phe Tyr Ile Ser Thr Tyr
              20                  25                  30        
 Leu Lys Thr Gln Gly Ala Phe Tyr Ile Cys Gly Gln Pro Val His Gln
          35                  40                  45            
 Cys Leu Pro Thr Asn Arg Thr Gly Thr Cys Thr Ile Gly Tyr Val Ser
      50                  55                  60                
 Leu Asp Ile Phe Ile Val Pro Gly Asn Leu Ser Leu Pro Ala Pro Ile
  65                  70                  75                  80
 Tyr Arg His Ser Ile Phe Ser Arg Met Arg Arg Ala Ile Gln Leu Ile
                  85                  90                  95    
 Leu Leu Leu Thr Gly Leu Gly Ile Ile Ala Ser Met Gly Thr Arg Ile
             100                 105                 110        
 Ala Arg Ile Thr Lys Ala Ser Leu Thr His Ser Gln Pro Ser Arg Glu
         115                 120                 125            
 Ile Ala Lys Asn Ile Asp Ala Thr Ala Lys Thr Leu Thr Thr Val Gln
     130                 135                 140                
 Glu Gln Ile Asp Ser Leu Ala Ala Ile Val Leu Gln Asn Tyr Gln Glu
 145                 150                 155                 160
 Leu Asp Lys Leu Thr Ala Ala Gln Arg Glu Thr Cys Leu Ala Leu Gly
                 165                 170                 175    
 Glu Lys Phe Cys Leu Trp Val Asn Gln Ser Gly Lys Val Gln Tyr Gln
             180                 185                 190        
 Thr Thr Pro Lys Leu Ser Leu Gln Phe Thr Gly Thr Ser Leu Ser Gly
         195                 200                 205            
 Leu Ala Ile Lys Leu Gln Met Ile Leu Ser Glu Arg Tyr His Arg Leu
     210                 215                 220                
 Asn Ile Gln Glu Ser His Phe Tyr Arg Gly Pro Leu Asp Cys Pro Ser
 225                 230                 235                 240
 Val Arg His Glu Arg Ser Glu Ile Leu Pro Leu Ser Pro Leu Asp Leu
                 245                 250                 255    
 Ala Gly Tyr His Phe His Gln Pro Thr Lys Pro Pro Cys Pro Asp Ser
             260                 265                 270        
 Lys Thr Pro Arg Pro Thr Glu Gln Ser Ser Pro Ser Phe Cys Gln Gln
         275                 280                 285            
 Glu Ala Val Thr Glu Asp
     290                



      <210> 1737
      <211> 203
      <212> PRT
      <213> Homo sapiens


      <400> 1737
 Met Val Leu Lys Val Ala Gly Pro Ala Cys Ala Val Val Gly Leu Gly
   1               5                  10                  15    
 Ala Val Ile Leu Ala Arg Ser Arg Ala Gln Leu Gln Leu Gly Ala Gly
              20                  25                  30        
 Leu Gln Arg Gly Gln Gln Met Asp Pro Asp Arg Ala Phe Ile Cys Gly
          35                  40                  45            
 Glu Ser Arg Gln Phe Ala Gln Cys Leu Ile Phe Gly Phe Leu Phe Leu
      50                  55                  60                
 Thr Ser Gly Met Leu Ile Ser Val Leu Gly Ile Trp Val Pro Gly Cys
  65                  70                  75                  80
 Gly Ser Lys Trp Ala Gln Glu Pro Leu Asn Glu Thr Asp Thr Gly Asp
                  85                  90                  95    
 Ser Glu Pro Arg Met Cys Gly Phe Leu Ser Leu Gln Ile Met Gly Pro
             100                 105                 110        
 Leu Ile Val Leu Val Gly Leu Cys Phe Phe Val Val Ala His Val Lys
         115                 120                 125            
 Lys Arg Asn Thr Leu Asn Ala Gly Gln Asp Ala Ser Glu Arg Glu Glu
     130                 135                 140                
 Gly Gln Ile Gln Ile Met Glu Pro Val Gln Val Thr Val Glu Ser Lys
 145                 150                 155                 160
 Lys His Ala Leu Leu Val Val Gly Thr Leu Ser Ala Ile Leu Asp Thr
                 165                 170                 175    
 Gln Gln Val Tyr Glu Thr Ala Leu Leu Gly Gly Val Tyr Met Leu Ser
             180                 185                 190        
 Ala His Arg Gly His Gln Val Leu Lys Asp Ala
         195                 200            



      <210> 1738
      <211> 171
      <212> PRT
      <213> Homo sapiens


      <400> 1738
 Met Val Ala Ala Val Leu Leu Gly Leu Ser Trp Leu Cys Ser Pro Leu
   1               5                  10                  15    
 Gly Ala Leu Val Leu Asp Phe Asn Asn Ile Arg Ser Ser Ala Asp Leu
              20                  25                  30        
 His Gly Ala Arg Lys Gly Ser Gln Cys Leu Ser Asp Thr Asp Cys Asn
          35                  40                  45            
 Thr Arg Lys Phe Cys Leu Gln Pro Arg Asp Glu Lys Pro Phe Cys Ala
      50                  55                  60                
 Thr Cys Arg Gly Leu Arg Arg Arg Cys Gln Arg Asp Ala Met Cys Cys
  65                  70                  75                  80
 Pro Gly Thr Leu Cys Val Asn Asp Val Cys Thr Thr Met Glu Asp Ala
                  85                  90                  95    
 Thr Pro Ile Leu Glu Arg Gln Leu Asp Glu Gln Asp Gly Thr His Ala
             100                 105                 110        
 Glu Gly Thr Thr Gly His Pro Val Gln Glu Asn Gln Pro Lys Arg Lys
         115                 120                 125            
 Pro Ser Ile Lys Lys Ser Gln Gly Arg Lys Gly Thr Asn Lys Phe Gln
     130                 135                 140                
 Leu Asn Phe His Leu Gln Val Asp Gln Lys Ser Phe Pro Pro Gly Ile
 145                 150                 155                 160
 Thr Arg Arg Tyr Tyr Leu Ala Asp Ala Asp Val
                 165                 170    



      <210> 1739
      <211> 472
      <212> PRT
      <213> Homo sapiens


      <400> 1739
 Met Asn Pro Cys Asp Ser Pro Leu Ala Val Thr Pro Arg Ser Phe Leu
   1               5                  10                  15    
 Gln Thr Leu Asn Leu Lys Glu Pro Leu Ile Tyr Phe Leu Ser Leu Trp
              20                  25                  30        
 Thr Phe Ile Leu Ser Ile Val Lys Gly Ser Gln Leu Ala Ser Ser Gln
          35                  40                  45            
 Glu Arg Asp Ser Gln Ser Trp Ile Gly Gly Asn Asn Glu Pro Leu Thr
      50                  55                  60                
 Gly Phe Thr Trp Arg Gly Gly Cys Glu Arg Glu Thr Thr Gly Ile Gln
  65                  70                  75                  80
 Val Trp Asn Glu Val Phe Val Ile Asp Arg Pro Asn Gly Thr Lys Val
                  85                  90                  95    
 Ala Val Leu Leu Met Asp Thr Gln Gly Ala Phe Asp Ser Gln Ser Thr
             100                 105                 110        
 Ile Lys Asp Cys Ala Thr Val Phe Ala Leu Ser Thr Met Thr Ser Ser
         115                 120                 125            
 Val Gln Thr Leu Met Phe Leu Ile Arg Asp Trp Ser Tyr Pro Tyr Glu
     130                 135                 140                
 His Ser Tyr Gly Leu Glu Gly Gly Lys Gln Phe Leu Glu Lys Arg Leu
 145                 150                 155                 160
 Gln Val Lys Gln Asn Gln His Glu Glu Leu Gln Asn Val Arg Lys His
                 165                 170                 175    
 Ile His Asn Cys Phe Ser Asn Leu Gly Cys Phe Leu Leu Pro His Pro
             180                 185                 190        
 Gly Leu Lys Val Ala Thr Asn Pro Ser Phe Asp Gly Arg Leu Lys Asp
         195                 200                 205            
 Ile Asp Glu Asp Phe Lys Arg Glu Leu Arg Asn Leu Val Pro Leu Leu
     210                 215                 220                
 Leu Ala Pro Glu Asn Leu Val Glu Lys Glu Ile Ser Gly Ser Lys Val
 225                 230                 235                 240
 Thr Cys Arg Asp Leu Val Glu Tyr Phe Lys Ala Tyr Ile Lys Ile Tyr
                 245                 250                 255    
 Gln Gly Glu Glu Leu Pro His Pro Lys Ser Met Leu Gln Ala Thr Ala
             260                 265                 270        
 Glu Ala Asn Asn Leu Ala Ala Val Ala Gly Ala Arg Asp Thr Tyr Cys
         275                 280                 285            
 Lys Ser Met Glu Gln Val Cys Gly Gly Asp Lys Pro Tyr Ile Ala Pro
     290                 295                 300                
 Ser Asp Leu Glu Arg Lys His Leu Asp Leu Lys Glu Val Ala Ile Lys
 305                 310                 315                 320
 Gln Phe Arg Ser Val Lys Lys Met Gly Gly Asp Glu Phe Cys Arg Arg
                 325                 330                 335    
 Tyr Gln Asp Gln Leu Glu Ala Glu Ile Glu Glu Thr Tyr Ala Asn Phe
             340                 345                 350        
 Ile Lys His Asn Asp Gly Lys Asn Ile Phe Tyr Ala Ala Arg Thr Pro
         355                 360                 365            
 Ala Thr Leu Phe Ala Val Met Phe Ala Met Tyr Ile Ile Ser Gly Leu
     370                 375                 380                
 Thr Gly Phe Ile Gly Leu Asn Ser Ile Ala Val Leu Cys Asn Leu Val
 385                 390                 395                 400
 Met Gly Leu Ala Leu Ile Phe Leu Cys Thr Trp Ala Tyr Val Lys Tyr
                 405                 410                 415    
 Ser Gly Glu Phe Arg Glu Ile Gly Thr Val Ile Asp Gln Ile Ala Glu
             420                 425                 430        
 Thr Leu Trp Glu Gln Val Phe Ser Lys Leu Phe Glu Val Thr Arg Arg
         435                 440                 445            
 Arg Met Val His Arg Ala Leu Ser Ser Ala Gln Arg Gln Arg Leu Ser
     450                 455                 460                
 Ser Asn Asn Asn Lys Lys Lys Asn
 465                 470        



      <210> 1740
      <211> 205
      <212> PRT
      <213> Homo sapiens


      <400> 1740
 Met Arg Ala Gly Leu Val Leu Ala Val Thr Leu Ser Leu Val Leu Leu
   1               5                  10                  15    
 Gly Ser Leu Ser Trp Gln Lys Cys Ile Lys Asp Gly Asn Trp Ser Ile
              20                  25                  30        
 Phe Val Ser Ser Pro Leu Leu His Gln Cys His Leu Ser Tyr Ser Glu
          35                  40                  45            
 Leu Lys Asn Ala His Ser Leu Gly Arg Ala Val Leu Phe Pro Ala Ala
      50                  55                  60                
 His Arg Pro Lys Arg Ser Ser Ser Leu Pro Leu Asn Pro Val Leu Gln
  65                  70                  75                  80
 Thr Ser Leu Glu Glu Val Glu Leu Leu Tyr Glu Phe Leu Leu Ala Glu
                  85                  90                  95    
 Leu Glu Ile Ser Pro Asp Leu Gln Ile Ser Ile Lys Asp Glu Glu Leu
             100                 105                 110        
 Ala Ser Leu Arg Lys Ala Ser Asp Phe Arg Thr Val Cys Asn Asn Val
         115                 120                 125            
 Ile Pro Lys Ser Ile Pro Asp Ile Arg Arg Leu Ser Ala Ser Leu Ser
     130                 135                 140                
 Ser His Pro Gly Ile Leu Lys Lys Glu Asp Phe Glu Arg Thr Val Leu
 145                 150                 155                 160
 Thr Leu Ala Tyr Thr Ala Tyr Arg Thr Ala Leu Ser His Gly His Gln
                 165                 170                 175    
 Lys Asp Ile Trp Ala Gln Ser Leu Val Ser Leu Phe Gln Ala Leu Arg
             180                 185                 190        
 His Asp Leu Met Arg Ser Ser Gln Pro Gly Val Pro Pro
         195                 200                 205



      <210> 1741
      <211> 502
      <212> PRT
      <213> Homo sapiens


      <400> 1741
 Met Met Phe Thr Phe Arg Phe Ile Thr Thr Leu Leu Val His Ile Phe
   1               5                  10                  15    
 Ile Ser Leu Val Ile Leu Gly Leu Leu Phe Val Cys Gly Val Leu Trp
              20                  25                  30        
 Trp Leu Tyr Tyr Asp Tyr Thr Asn Asp Leu Ser Ile Glu Leu Asp Thr
          35                  40                  45            
 Glu Arg Glu Asn Met Lys Cys Val Leu Gly Phe Ala Ile Val Ser Thr
      50                  55                  60                
 Gly Ile Thr Ala Val Leu Leu Val Leu Ile Phe Val Leu Arg Lys Arg
  65                  70                  75                  80
 Ile Lys Leu Thr Val Glu Leu Phe Gln Ile Thr Asn Lys Ala Ile Ser
                  85                  90                  95    
 Ser Ala Pro Phe Leu Leu Phe Gln Pro Leu Trp Thr Phe Ala Ile Leu
             100                 105                 110        
 Ile Phe Phe Trp Val Leu Trp Val Ala Val Leu Leu Ser Leu Gly Thr
         115                 120                 125            
 Ala Glu Trp Phe Ser Glu Ser Thr Asp Leu Ile Tyr Leu Thr Gly Ile
     130                 135                 140                
 Leu Phe Arg Arg Gly His Leu Leu Trp Asn Trp Glu Cys Phe Leu Lys
 145                 150                 155                 160
 His Ala Leu Asn His Pro Ile Leu Glu Asn His Arg His Leu Ser Met
                 165                 170                 175    
 Pro Tyr Pro Lys Gln Arg Leu Pro Pro Ser Gln Arg Ala Ala Gln Val
             180                 185                 190        
 Met Glu Gly Gly Gln Val Glu Tyr Lys Pro Leu Ser Gly Ile Arg Tyr
         195                 200                 205            
 Met Trp Ser Tyr His Leu Ile Gly Leu Ile Trp Thr Ser Glu Phe Ile
     210                 215                 220                
 Leu Ala Cys Gln Gln Met Thr Ile Ala Gly Ala Val Val Thr Cys Tyr
 225                 230                 235                 240
 Phe Asn Arg Ser Lys Asn Asp Pro Pro Asp His Pro Ile Leu Ser Ser
                 245                 250                 255    
 Leu Ser Ile Leu Phe Phe Tyr His Gln Gly Thr Ile Val Lys Gly Ser
             260                 265                 270        
 Phe Leu Ile Ser Val Val Arg Ile Pro Arg Ile Ile Val Met Tyr Met
         275                 280                 285            
 Gln Asn Ala Leu Lys Glu Gln Asn Ala Tyr Thr Thr Thr Ala Ile Asn
     290                 295                 300                
 Gly Thr Asp Phe Cys Thr Ser Ala Lys Asp Ala Phe Lys Ile Leu Ser
 305                 310                 315                 320
 Lys Asn Ser Ser His Phe Thr Ser Ile Asn Cys Phe Gly Asp Phe Ile
                 325                 330                 335    
 Ile Phe Leu Gly Lys Val Leu Val Val Cys Phe Thr Val Phe Gly Gly
             340                 345                 350        
 Leu Met Ala Phe Asn Tyr Asn Arg Ala Phe Gln Val Trp Ala Val Pro
         355                 360                 365            
 Leu Leu Leu Val Ala Phe Phe Ala Tyr Leu Val Ala His Ser Phe Leu
     370                 375                 380                
 Ser Val Phe Glu Thr Val Leu Asp Ala Leu Phe Leu Cys Phe Ala Val
 385                 390                 395                 400
 Asp Leu Glu Thr Asn Asp Gly Ser Ser Glu Lys Pro Tyr Phe Met Asp
                 405                 410                 415    
 Gln Glu Phe Leu Val Ser Lys His Phe Ile Ser Ser Cys Asn Leu His
             420                 425                 430        
 Ala Arg Asn Leu Glu Ser Phe Val Lys Leu His Thr Arg Lys Arg Leu
         435                 440                 445            
 Ile Pro Ser Leu Ser Leu Leu Glu Gly Ser Glu Ala Ser Thr Thr Pro
     450                 455                 460                
 Gly Pro Glu Ser Gly Ile Cys Ala Glu Leu Ser Lys Ala Glu Pro Thr
 465                 470                 475                 480
 Ser Leu Ser Glu Asn Leu Leu Pro Glu Glu Val Lys Leu Asn Lys Asn
                 485                 490                 495    
 Ala Asp Gln Met Asp Ser
             500        



      <210> 1742
      <211> 737
      <212> PRT
      <213> Homo sapiens


      <400> 1742
 Met Trp Glu Ser Ser Leu His Leu Lys Leu Gly Pro Cys Leu Ala Val
   1               5                  10                  15    
 Arg Ser Pro Leu Trp Thr Cys Thr Leu Gly Asp Gly Glu His Cys Ser
              20                  25                  30        
 Leu Ala Ala Val Ser Arg Val Cys Pro Ala Pro Tyr Leu Gly Ser His
          35                  40                  45            
 Val Thr Val Cys Pro Val Val Val Ser Arg Ala Ser Leu Gly Thr Thr
      50                  55                  60                
 Ala Pro Ala Arg Leu Thr Gln Arg His Leu Glu Met Gln Thr Arg Asp
  65                  70                  75                  80
 Lys Arg Ala His Leu Ala Ser Asp Ser Leu Pro Lys Thr Pro Gly Ala
                  85                  90                  95    
 Glu Gly Ser Arg Thr Ala Pro Lys Gly Ala Leu Arg Thr Glu Leu Ala
             100                 105                 110        
 Met Ala Thr Glu Ser Val Trp Met Leu Glu Phe Ser Ala Ile Ile Pro
         115                 120                 125            
 Lys Ala Ala Leu Cys Ala Ile Thr Val Thr Gln Gln Thr Glu Ala Ala
     130                 135                 140                
 Leu Leu Lys Thr Leu Asn Ser Ser Val Asn Tyr Leu Tyr Gly Ser Leu
 145                 150                 155                 160
 His Lys Glu Val Pro Ala Ala Ala Phe Thr Gln Tyr Gln Val Gln Gly
                 165                 170                 175    
 His Lys Ser Gln Gly Met Gln Lys Glu Ser Leu Arg Phe Arg Asn Ile
             180                 185                 190        
 Ala Ser Ala Leu Asp Asp Leu Asp Ala Ile Val Ala Lys Val Gln Leu
         195                 200                 205            
 Pro Gln Val His Gln Val Leu Gln Thr Leu Asp Leu Gly Gln Pro Val
     210                 215                 220                
 Ala Leu Gln Glu Gly Glu His Thr Ala Val Arg Thr Val Gln Lys Tyr
 225                 230                 235                 240
 Leu Lys Ser Phe Asn Leu Pro Tyr Ala Ile Val Ile Gln Ile Asn Ile
                 245                 250                 255    
 Leu Lys Gln Ser Arg Asn Leu Tyr Ser Ala Ile Ala Lys Trp Leu Glu
             260                 265                 270        
 Thr Cys Val Val Leu Glu Glu Ala Ala Trp Lys Trp Ala Ala Val Gly
         275                 280                 285            
 Glu Ala Val Pro Glu Asp Arg Trp Ser Ser Tyr Cys Leu Ser Ser Leu
     290                 295                 300                
 Ala Ala Gln Asn Ile Cys Thr Ser Lys Leu His Cys Pro Ala Ala Pro
 305                 310                 315                 320
 Glu His Thr Asp Pro Ser Glu Pro Arg Gly Ser Val Ser Cys Cys Ser
                 325                 330                 335    
 Leu Leu Arg Gly Leu Ser Ser Gly Trp Ser Ser Pro Leu Leu Pro Ala
             340                 345                 350        
 Pro Val Cys Asn Pro Asn Lys Ala Ile Phe Thr Val Asp Ala Lys Thr
         355                 360                 365            
 Thr Glu Ile Leu Val Ala Asn Asp Lys Ala Cys Gly Leu Leu Gly Tyr
     370                 375                 380                
 Ser Ser Gln Asp Leu Ile Gly Gln Lys Leu Thr Gln Phe Phe Leu Arg
 385                 390                 395                 400
 Ser Asp Ser Asp Val Val Glu Ala Leu Ser Glu Glu His Met Glu Ala
                 405                 410                 415    
 Asp Gly His Ala Ala Val Val Phe Gly Thr Val Val Asp Ile Ile Ser
             420                 425                 430        
 Arg Ser Gly Glu Lys Ile Pro Val Ser Val Trp Met Lys Arg Met Arg
         435                 440                 445            
 Gln Glu Arg Arg Leu Cys Cys Val Val Val Leu Glu Pro Val Glu Arg
     450                 455                 460                
 Val Ser Thr Trp Val Ala Phe Gln Ser Asp Gly Thr Val Thr Ser Cys
 465                 470                 475                 480
 Asp Ser Leu Phe Ala His Leu His Gly Tyr Val Ser Gly Glu Asp Val
                 485                 490                 495    
 Ala Gly Gln His Ile Thr Asp Leu Ile Pro Ser Val Gln Leu Pro Pro
             500                 505                 510        
 Ser Gly Gln His Ile Pro Lys Asn Leu Lys Ile Gln Arg Ser Val Gly
         515                 520                 525            
 Arg Ala Arg Asp Gly Thr Thr Phe Pro Leu Ser Leu Lys Leu Lys Ser
     530                 535                 540                
 Gln Pro Ser Ser Glu Glu Ala Thr Thr Gly Glu Ala Ala Pro Val Ser
 545                 550                 555                 560
 Gly Tyr Arg Ala Ser Val Trp Val Phe Cys Thr Ile Ser Gly Leu Ile
                 565                 570                 575    
 Thr Leu Leu Pro Asp Gly Thr Ile His Gly Ile Asn His Ser Phe Ala
             580                 585                 590        
 Leu Thr Leu Phe Gly Tyr Gly Lys Thr Glu Leu Leu Gly Lys Asn Ile
         595                 600                 605            
 Thr Phe Leu Ile Pro Gly Phe Tyr Ser Tyr Met Asp Leu Ala Tyr Asn
     610                 615                 620                
 Ser Ser Leu Gln Leu Pro Asp Leu Ala Ser Cys Leu Asp Val Gly Asn
 625                 630                 635                 640
 Glu Ser Gly Cys Gly Glu Arg Thr Leu Asp Pro Trp Gln Gly Gln Asp
                 645                 650                 655    
 Pro Ala Glu Gly Gly Gln Asp Pro Arg Ile Asn Val Val Leu Ala Gly
             660                 665                 670        
 Gly His Val Val Pro Arg Asp Glu Ile Arg Lys Leu Met Glu Ser Gln
         675                 680                 685            
 Asp Ile Phe Thr Gly Thr Gln Thr Glu Leu Ile Ala Gly Gly Gln Leu
     690                 695                 700                
 Leu Ser Cys Leu Ser Pro Gln Pro Ala Pro Gly Asp Lys Glu Thr Gly
 705                 710                 715                 720
 Cys Gly Glu Phe Gln Asn Val Glu Val Asp Phe Arg Glu Leu Met Glu
                 725                 730                 735    
 Ser
    



      <210> 1743
      <211> 285
      <212> PRT
      <213> Homo sapiens


      <400> 1743
 Met Asp Ile Pro Ile Ser Ser Arg Asp Phe Arg Gly Leu Gln Leu Ala
   1               5                  10                  15    
 Cys Val Ala Leu Gly Leu Val Ala Gly Ser Ile Ile Ile Gly Ile Ser
              20                  25                  30        
 Val Ser Lys Ala Ala Ala Ala Met Gly Gly Val Phe Ile Gly Ala Ala
          35                  40                  45            
 Val Leu Gly Leu Leu Ile Leu Ala Tyr Pro Phe Leu Lys Ala Arg Phe
      50                  55                  60                
 Asn Leu Asp His Ile Leu Pro Thr Ile Gly Ala Asp His Gly Glu Gly
  65                  70                  75                  80
 Arg Ser Ser Thr Asn Gly Asn Lys Glu Gly Val Val Asn Val Glu Thr
                  85                  90                  95    
 Cys Gly Phe Ser Pro Ser His Phe Glu Lys Arg Pro Met Pro Pro Ala
             100                 105                 110        
 Glu Lys Ser Glu Gly Pro Pro Val Pro Ala Pro Ala Glu Arg Ala Arg
         115                 120                 125            
 Gly Arg Val Pro Gly Leu Pro Ser Pro Ala Leu Cys Cys Ala Cys Gly
     130                 135                 140                
 Leu Cys Ala Leu Leu Ala Gly Val Asn Val Thr Leu Ala Gly Ala Phe
 145                 150                 155                 160
 Ala Ser Phe Leu Pro Glu His Asn Ala Leu Leu Val Val Gly Leu Ala
                 165                 170                 175    
 Leu Leu Val Leu Ala Leu Gly Phe Phe Ala Ala Cys Cys Val Cys Ser
             180                 185                 190        
 Arg Arg Gly Leu Ala Pro Arg Gly Arg Ser Ala Ala Ala Ala Gly Pro
         195                 200                 205            
 Gly Gln Gly Gly Gly Arg Ala Gly Pro Val Ala Leu Glu Met Glu Ser
     210                 215                 220                
 Ser Glu Pro Thr Ala Gln Asp Thr Thr Ala Val Gln Leu Ser Pro Ala
 225                 230                 235                 240
 Val Ser Ala Ala Ser Ser Gly Cys Ser Ser Pro Gly Pro Ser Pro Leu
                 245                 250                 255    
 Ala Leu Glu Ala Pro Ala Pro Ala Ala Val Cys Ala Leu Arg Ser Glu
             260                 265                 270        
 Gly Val Gln Leu Asn Pro Pro Arg Ala Arg Ala Ala Pro
         275                 280                 285



      <210> 1744
      <211> 783
      <212> PRT
      <213> Homo sapiens


      <400> 1744
 Met Ala Leu Val Glu Ile Gly Ala Ala Ser Leu Cys Leu Gly Ala Ile
   1               5                  10                  15    
 Leu Arg Leu Glu Ala Gly Cys Cys Thr Glu Arg Leu Val Gly Val Thr
              20                  25                  30        
 Gly Gly Asp Glu Gly Lys Pro Gly Pro Leu Pro Val Ser Ser Leu Leu
          35                  40                  45            
 Leu Glu Lys Trp Thr Phe Pro Lys Ser Gly Arg Ser Arg Ser Arg Val
      50                  55                  60                
 Ala Cys Phe Val Leu Val Trp Tyr Asp Leu Asp Ser Leu Glu Gln Phe
  65                  70                  75                  80
 Pro Val Pro Leu Gly Tyr Asp Asn Asn Ile Thr Pro Phe Gln Lys Leu
                  85                  90                  95    
 Leu Ile Leu Arg Cys Phe Arg Val Asp Arg Val Tyr Arg Ala Val Thr
             100                 105                 110        
 Asp Tyr Val Thr Val Thr Met Gly Glu Lys Tyr Val Gln Pro Pro Met
         115                 120                 125            
 Ile Ser Phe Glu Ala Ile Phe Glu Gln Ser Thr Pro His Ser Pro Ile
     130                 135                 140                
 Val Phe Ile Leu Ser Pro Gly Ser Asp Pro Ala Thr Asp Leu Met Lys
 145                 150                 155                 160
 Leu Ala Glu Arg Ser Gly Phe Gly Gly Asn Arg Leu Lys Phe Leu Ala
                 165                 170                 175    
 Met Gly Gln Gly Gln Glu Lys Ala Gly Cys Asp Gln Leu Ser Ala Pro
             180                 185                 190        
 Thr Gly Pro Met Gly Phe Leu Lys Asp Gly Leu Phe Glu Gly Ser Thr
         195                 200                 205            
 Cys Ser Ser Trp Ile Leu Gly Leu Leu Leu Ala Ser Ala Gly Ala Ala
     210                 215                 220                
 Ile Ala Leu Leu Trp Val Ala Leu Gln Leu Leu Glu Thr Ala Val Ala
 225                 230                 235                 240
 Arg Gly Gln Trp Leu Met Leu Gln Asn Cys His Leu Leu Val Lys Trp
                 245                 250                 255    
 Leu Lys Asp Leu Glu Lys Ser Leu Glu Arg Ile Thr Lys Pro His Pro
             260                 265                 270        
 Asp Phe Arg Leu Trp Leu Thr Thr Asp Pro Thr Lys Gly Phe Pro Ile
         275                 280                 285            
 Gly Ile Leu Gln Lys Ser Leu Lys Val Val Thr Glu Pro Pro Asn Gly
     290                 295                 300                
 Leu Lys Leu Asn Met Arg Ala Thr Tyr Phe Lys Ile Ser His Glu Met
 305                 310                 315                 320
 Leu Asp Gln Cys Pro His Pro Ala Phe Lys Pro Leu Val Tyr Val Leu
                 325                 330                 335    
 Ala Phe Phe His Ala Val Val Gln Glu Arg Arg Lys Phe Gly Lys Ile
             340                 345                 350        
 Gly Trp Asn Val Tyr Tyr Asp Phe Asn Glu Ser Asp Phe Gln Val Cys
         355                 360                 365            
 Met Glu Ile Leu Asn Thr Tyr Leu Thr Lys Ala Phe Gln Gln Arg Asp
     370                 375                 380                
 Pro Arg Ile Pro Trp Gly Ser Leu Lys Tyr Leu Ile Gly Glu Val Met
 385                 390                 395                 400
 Tyr Gly Gly Arg Ala Ile Asp Ser Phe Asp Arg Arg Ile Leu Thr Ile
                 405                 410                 415    
 Tyr Met Asp Glu Tyr Leu Gly Asp Phe Ile Phe Asp Thr Phe Gln Pro
             420                 425                 430        
 Phe His Phe Phe Arg Asn Lys Glu Val Asp Tyr Lys Ile Pro Val Gly
         435                 440                 445            
 Asp Glu Lys Glu Lys Phe Val Glu Ala Ile Glu Ala Leu Pro Leu Ala
     450                 455                 460                
 Asn Thr Pro Glu Val Phe Gly Leu His Pro Asn Ala Glu Ile Gly Tyr
 465                 470                 475                 480
 Tyr Thr Gln Ala Ala Arg Asp Met Trp Ala His Leu Leu Glu Leu Gln
                 485                 490                 495    
 Pro Gln Thr Gly Glu Ser Ser Ser Gly Ile Ser Arg Asp Asp Tyr Ile
             500                 505                 510        
 Gly Gln Val Ala Lys Glu Ile Glu Asn Lys Met Pro Lys Val Phe Asp
         515                 520                 525            
 Leu Asp Gln Val Arg Lys Arg Leu Gly Thr Gly Leu Ser Pro Thr Ser
     530                 535                 540                
 Val Val Leu Leu Gln Glu Leu Glu Arg Phe Asn Lys Leu Val Val Arg
 545                 550                 555                 560
 Met Thr Lys Ser Leu Ala Glu Leu Gln Arg Ala Leu Ala Gly Glu Val
                 565                 570                 575    
 Gly Met Ser Asn Glu Leu Asp Asp Val Ala Arg Ser Leu Phe Ile Gly
             580                 585                 590        
 His Ile Pro Asn Ile Trp Arg Arg Leu Ala Pro Asp Thr Leu Lys Ser
         595                 600                 605            
 Leu Gly Asn Trp Met Val Tyr Phe Leu Arg Arg Phe Ser Gln Tyr Met
     610                 615                 620                
 Leu Trp Val Thr Glu Ser Glu Pro Ser Val Met Trp Leu Ser Gly Leu
 625                 630                 635                 640
 His Ile Pro Glu Ser Tyr Leu Thr Ala Leu Val Gln Ala Thr Cys Arg
                 645                 650                 655    
 Lys Asn Gly Trp Pro Leu Asp Arg Ser Thr Leu Phe Thr Gln Val Thr
             660                 665                 670        
 Lys Phe Gln Asp Ala Asp Glu Val Asn Glu Arg Ala Gly Gln Gly Cys
         675                 680                 685            
 Phe Val Ser Gly Leu Tyr Leu Glu Gly Ala Asp Trp Asp Ile Glu Lys
     690                 695                 700                
 Gly Cys Leu Ile Lys Ser Lys Pro Lys Val Leu Val Val Asp Leu Pro
 705                 710                 715                 720
 Ile Leu Lys Ile Ile Pro Ile Glu Ala His Arg Leu Lys Leu Gln Asn
                 725                 730                 735    
 Thr Phe Arg Thr Pro Val Tyr Thr Thr Ser Met Arg Arg Asn Ala Met
             740                 745                 750        
 Gly Val Gly Leu Val Phe Glu Ala Asp Leu Phe Thr Thr Arg His Ile
         755                 760                 765            
 Ser His Trp Val Leu Gln Gly Val Cys Leu Thr Leu Asn Ser Asp
     770                 775                 780            



      <210> 1745
      <211> 781
      <212> PRT
      <213> Homo sapiens


      <400> 1745
 Met His Gly Ser Cys Ser Phe Leu Met Leu Leu Leu Pro Leu Leu Leu
   1               5                  10                  15    
 Leu Leu Val Ala Thr Thr Gly Pro Val Gly Ala Leu Thr Asp Glu Glu
              20                  25                  30        
 Lys Arg Leu Met Val Glu Leu His Asn Leu Tyr Arg Ala Gln Val Ser
          35                  40                  45            
 Pro Thr Ala Ser Asp Met Leu His Met Arg Trp Asp Glu Glu Leu Ala
      50                  55                  60                
 Ala Phe Ala Lys Ala Tyr Ala Arg Gln Cys Val Trp Gly His Asn Lys
  65                  70                  75                  80
 Glu Arg Gly Arg Arg Gly Glu Asn Leu Phe Ala Ile Thr Asp Glu Gly
                  85                  90                  95    
 Met Asp Val Pro Leu Ala Met Glu Glu Trp His His Glu Arg Glu His
             100                 105                 110        
 Tyr Asn Leu Ser Ala Ala Thr Cys Ser Pro Gly Gln Met Cys Gly His
         115                 120                 125            
 Tyr Thr Gln Val Val Trp Ala Lys Thr Glu Arg Ile Gly Cys Gly Ser
     130                 135                 140                
 His Phe Cys Glu Lys Leu Gln Gly Val Glu Glu Thr Asn Ile Glu Leu
 145                 150                 155                 160
 Leu Val Cys Asn Tyr Glu Pro Pro Ile Leu Leu Thr Ser Cys Arg Gly
                 165                 170                 175    
 Asn Val Lys Gly Lys Arg Pro Tyr Gln Glu Gly Thr Pro Cys Ser Gln
             180                 185                 190        
 Cys Pro Ser Gly Tyr His Cys Lys Asn Ser Leu Cys Ala Thr Gly Ile
         195                 200                 205            
 Pro Ala Phe Leu Val Thr Glu Val Ser Gly Ser Leu Ala Thr Lys Ala
     210                 215                 220                
 Leu Pro Ala Val Glu Thr Gln Ala Pro Thr Ser Leu Ala Thr Lys Asp
 225                 230                 235                 240
 Pro Pro Ser Met Ala Thr Glu Ala Pro Pro Cys Val Thr Thr Glu Val
                 245                 250                 255    
 Pro Ser Ile Leu Ala Ala His Ser Leu Pro Ser Leu Asp Glu Glu Pro
             260                 265                 270        
 Val Thr Phe Pro Lys Ser Thr His Val Pro Ile Pro Lys Ser Ala Asp
         275                 280                 285            
 Lys Val Thr Asp Lys Thr Lys Val Pro Ser Arg Ser Pro Glu Asn Ser
     290                 295                 300                
 Leu Asp Pro Lys Met Ser Leu Thr Gly Ala Arg Glu Leu Leu Pro His
 305                 310                 315                 320
 Ala Gln Glu Glu Ala Glu Ala Glu Ala Glu Leu Pro Pro Ser Ser Glu
                 325                 330                 335    
 Val Leu Ala Ser Val Phe Pro Ala Gln Asp Lys Pro Gly Glu Leu Gln
             340                 345                 350        
 Ala Thr Leu Asp His Thr Gly His Thr Ser Ser Lys Ser Leu Pro Asn
         355                 360                 365            
 Phe Pro Asn Thr Ser Ala Thr Ala Asn Ala Thr Gly Gly Arg Ala Leu
     370                 375                 380                
 Ala Leu Gln Ser Ser Leu Pro Gly Gln Ser Met Ile Leu Met Thr Pro
 385                 390                 395                 400
 Gly Gly Lys Ala Gly Trp Ser Leu Gly Arg Ala Gly Pro Gly Pro Glu
                 405                 410                 415    
 Gly Lys Val Ser Leu Glu Ala Thr Gln Ser Ser Gly Ser Leu Arg Ala
             420                 425                 430        
 Thr Ala Pro Phe His Cys Glu Ala Asn Gln Gly Gln Glu Lys Ala Arg
         435                 440                 445            
 Phe Cys Pro Arg Pro Lys Pro Gly Pro Leu Thr Ala Gly Pro Lys Ser
     450                 455                 460                
 Ser Ser Tyr Gly Glu Val Ala Ser Val Gln Asn Thr Arg Thr Gln Asp
 465                 470                 475                 480
 Thr Lys Tyr Leu Leu Thr Ile Leu Asn Ser Met Lys Pro Leu Ile Phe
                 485                 490                 495    
 Ala Cys Asn Glu Ala Ser Thr Lys Pro Phe Gln Leu Lys Asp Val Ala
             500                 505                 510        
 Lys Asn Arg Lys Gly Leu Arg Arg Pro Val Leu Ala His Leu His Thr
         515                 520                 525            
 Gln Val Ile Leu Ala Asp Thr Ser Pro Gly Pro Pro Ser Leu Leu Gly
     530                 535                 540                
 Gly Lys Ala Thr Ser Arg Arg Asn Ala Ile Leu Leu Glu Gly Asp Pro
 545                 550                 555                 560
 His Cys Glu Asn Val Trp Thr Leu Gln Phe Pro Ala Ile Ala Ala Pro
                 565                 570                 575    
 Tyr Leu Leu Ser Trp Phe Arg Gln Asn Gln Ser Thr Pro Gln Thr Leu
             580                 585                 590        
 Gly Ile Ser Ser Thr Arg Lys Glu Gly Gln Val Leu Val Pro Thr Asn
         595                 600                 605            
 Leu Gly Thr Trp Ile Leu Val Val Ser Gln Pro Pro Trp Gly Val Thr
     610                 615                 620                
 His Ala Val Ile His Gln Val Gly Ile Asp Glu Val Gly Gln Gln Val
 625                 630                 635                 640
 Thr Ala Pro Gln Glu Asn His Ile Ala Gln Glu Gly Ser Leu His Ile
                 645                 650                 655    
 Ile Leu Val Gly Asn Leu Leu Asn Leu Ile Trp Arg Glu Asn Leu Lys
             660                 665                 670        
 Gln Arg Arg Glu Arg Thr Lys Phe Ser Tyr Ala Ser Ser Met Glu Leu
         675                 680                 685            
 Phe Gly Asp Leu Gly Gly Arg Asn Gln Leu Gln Ile Phe Pro Leu Gln
     690                 695                 700                
 Cys Leu Leu Ala Gly Pro Thr Ser Asp Ser Ala Leu Asn Asn Thr Gly
 705                 710                 715                 720
 Thr Lys Leu Glu Glu Lys Tyr Asp Thr Gln Phe Cys Gln Gln His Val
                 725                 730                 735    
 Lys Trp Lys Arg His Leu Cys Leu Ser Pro Pro Ala Val Trp Ala Gly
             740                 745                 750        
 Ser Trp Gln Leu Gln Ala Glu Glu Leu Asp Gln Ser Cys Met Val His
         755                 760                 765            
 Leu Leu Ala Pro Arg His His Val Leu Ser Val His Ala
     770                 775                 780    



      <210> 1746
      <211> 270
      <212> PRT
      <213> Homo sapiens


      <400> 1746
 Met Leu Asp Phe Ala Ile Phe Ala Val Thr Phe Leu Leu Ala Leu Val
   1               5                  10                  15    
 Gly Ala Val Leu Tyr Leu Tyr Pro Gly Ile Phe Leu Ser Asp Tyr Phe
              20                  25                  30        
 Asp Thr Glu Ile Phe Asn Leu Ser Val Ser Ala Asp Pro Phe Glu Thr
          35                  40                  45            
 Met Leu Lys Ser Leu Leu Arg Tyr Gln Ser Gly Gly Gly Ser Val Ser
      50                  55                  60                
 Glu Asn His Met Arg Lys Lys Leu Tyr Glu Asn Gly Val Thr Asp Ser
  65                  70                  75                  80
 Leu Lys Ser Asn Phe Ala Leu Leu Leu Lys Leu Ser Glu Glu Leu Leu
                  85                  90                  95    
 Asp Lys Trp Leu Ser Tyr Pro Glu Thr Gln His Val Pro Leu Ser Gln
             100                 105                 110        
 His Met Leu Gly Phe Ala Met Lys Ser Val Thr Gln Met Val Met Gly
         115                 120                 125            
 Ser Thr Phe Glu Asp Asp Gln Glu Val Ile Arg Phe Gln Lys Asn His
     130                 135                 140                
 Gly Thr Val Trp Ser Glu Ile Gly Lys Gly Phe Leu Asp Gly Ser Leu
 145                 150                 155                 160
 Asp Lys Asn Met Thr Arg Lys Lys Gln Tyr Glu Asp Gly Val Ala Val
                 165                 170                 175    
 Trp Leu Val Asp Asn Thr Ala Asn Ile Pro Leu His Leu Trp Tyr Cys
             180                 185                 190        
 Gln Ala Ser Glu Ile Leu Asn Pro Phe Asp Asp Val Ser Leu Val Tyr
         195                 200                 205            
 Cys Cys Ser Ser Val Ser Ser Thr Val Leu His Met Gln Gln Thr Leu
     210                 215                 220                
 Val Leu Tyr Ala Leu Gly Val Val Leu Gln Asp Pro Asn Thr Trp Pro
 225                 230                 235                 240
 Ser Pro His Lys Tyr Glu Ile Phe Val Ile Val Phe Val Thr Val Ser
                 245                 250                 255    
 Phe Cys Val Cys Thr Phe Cys Ile Pro Phe Leu Thr Val Glu
             260                 265                 270



      <210> 1747
      <211> 185
      <212> PRT
      <213> Homo sapiens


      <400> 1747
 Met Thr Arg Ile Leu Ile Ala Thr Phe Leu Phe Ile Cys Trp Ala Thr
   1               5                  10                  15    
 Leu Gln Leu Gln Val Val Thr Arg Val Asn Ile Lys Phe Lys Leu Gln
              20                  25                  30        
 Val Ala Ala Asn Ile His Glu Leu Asp Pro Met Leu Leu Pro Phe Phe
          35                  40                  45            
 Leu Val Phe Val Val Phe Arg Leu Leu Phe Trp Leu Leu Pro Thr Lys
      50                  55                  60                
 Asn Leu Gly Gly Lys Leu Lys Val Gly Gln Pro Tyr Cys Asn Asp Glu
  65                  70                  75                  80
 Thr Thr Arg Lys Ile Asn Ala His Val Lys His Cys Arg Val Glu Lys
                  85                  90                  95    
 Gly Ala Trp Gly Asp Asp Gly Pro Glu Ala Lys Asp Glu Asp Ser Gly
             100                 105                 110        
 Lys His Trp Leu Val Thr Lys Glu Ile Ala Lys Asp Thr Met Lys Arg
         115                 120                 125            
 Cys Ile Gly Lys Asn Arg Leu Met Gln Lys Ile Gly Thr Lys Glu Trp
     130                 135                 140                
 Gly Val Ala Val Asn Ile Pro Glu Asn Val Glu Val Thr Leu Glu Leu
 145                 150                 155                 160
 Gly Asn Cys Gln Arg Leu Glu Glu Cys Glu Val Leu Arg Arg Arg Gln
                 165                 170                 175    
 Glu Asn Glu Gly Lys Phe Gly Thr Ser
             180                 185



      <210> 1748
      <211> 477
      <212> PRT
      <213> Homo sapiens


      <400> 1748
 Met Gln Leu Gln Val Phe Trp Thr Gly Leu Glu Tyr Thr Cys Arg Leu
   1               5                  10                  15    
 Leu Gly Ile Thr Thr Ala Ala Ala Pro Gln Met Pro Glu Thr Leu Glu
              20                  25                  30        
 Cys Trp Ala Gln Ser Tyr Phe Thr Asn Glu Glu Thr Glu Ala Gln Asn
          35                  40                  45            
 Ile Glu Val Gly Ile Gln Asn Glu Ile Trp Val Gly Thr Gln Pro Asn
      50                  55                  60                
 His Thr Arg Val Leu Thr Arg Glu Met Leu Phe Tyr Val Gly Asp Thr
  65                  70                  75                  80
 Ile Leu Ser Ser Ala Asn Glu Pro Tyr Gly Ser Ala Glu Ser Phe Leu
                  85                  90                  95    
 Ile Thr Lys Glu Trp Gly Ile Ser Thr Asp Gly Leu Thr Val Leu Ile
             100                 105                 110        
 Gly Val Gly Thr Glu Thr Phe Leu Gln Gly Gln Phe Lys Ser Leu Ala
         115                 120                 125            
 Phe Tyr Leu Leu Phe Thr Gly Ala Ala Val Ser Ile Cys Glu Gly Ala
     130                 135                 140                
 Tyr Phe Val Ala Gln Leu Leu Ala Ile Cys Phe Gln Cys Gln Pro Gly
 145                 150                 155                 160
 Ser Leu Ala Asp Arg Val Arg Glu Lys Ala His Trp Leu Gly Cys Phe
                 165                 170                 175    
 Gln Lys Phe Leu Ala Tyr Leu Leu Leu Ser Val Ala Cys Phe Leu His
             180                 185                 190        
 Pro Val Leu Val Trp His Val Thr Ile Pro Gly Ser Met Leu Ile Ile
         195                 200                 205            
 Thr Gly Leu Ala Tyr Phe Leu Leu Ser Lys Arg Lys Lys Arg Lys Ala
     210                 215                 220                
 Ala Pro Glu Val Leu Ala Ser Pro Glu Gln Tyr Thr Asp Pro Ser Ser
 225                 230                 235                 240
 Ser Ala Val Ser Thr Thr Gly Ser Gly Asp Thr Glu Gln Thr Tyr Thr
                 245                 250                 255    
 Phe His Gly Ala Leu Lys Glu Gly Pro Ser Ser Leu Phe Ile His Met
             260                 265                 270        
 Lys Ser Ile Leu Lys Gly Thr Lys Lys Pro Ser Ala Leu Gln Pro Pro
         275                 280                 285            
 Asn Thr Leu Met Glu Leu Ser Leu Glu Pro Ala Asp Ser Leu Ala Lys
     290                 295                 300                
 Lys Lys Gln Val His Phe Glu Asp Asn Leu Val Arg Ile Val Pro Ser
 305                 310                 315                 320
 Leu Ala Glu Gly Leu Asp Asp Gly Asp Ser Pro Thr Leu Pro Val Ile
                 325                 330                 335    
 Ser Tyr Ser His Arg Pro Val Leu Ser Ala Cys Ser Ser Leu Glu Asp
             340                 345                 350        
 Ala Gln Ile Phe Tyr Lys Gly Met Lys Ile Met Ala Asn Gln Lys Leu
         355                 360                 365            
 Val Ser Val Trp Gly Leu Asn Ala Ala Gly Val Pro Asp Lys Gln Ile
     370                 375                 380                
 Ser Arg Ala Leu Pro Ala Val Ala Gln Val Ser Pro Asn Asp Lys Trp
 385                 390                 395                 400
 Leu Ile Lys Thr Leu Leu Gln Ala Leu Asp Gly Glu Ser Cys Arg Ala
                 405                 410                 415    
 Val Ser Ser Ala Ala Ile Lys Ala Gly Pro Gln Asp Leu Thr Val Tyr
             420                 425                 430        
 Ser Gln Gly Ile Val Asn Asn Met Gly Tyr Gly Tyr Arg Val Val Leu
         435                 440                 445            
 Ser Ser Lys Pro Gln Ser Ala Glu Leu Asp Asp Gln Ile Ala Arg Ser
     450                 455                 460                
 Lys Pro Glu Ser Val Met Ala Glu Met Ser Asp Pro Val
 465                 470                 475        



      <210> 1749
      <211> 693
      <212> PRT
      <213> Homo sapiens


      <400> 1749
 Met Met Leu Leu Leu Leu Cys Leu Gly Leu Thr Leu Val Cys Ala Gln
   1               5                  10                  15    
 Glu Glu Glu Asn Asn Asp Ala Val Thr Ser Asn Phe Asp Leu Ser Lys
              20                  25                  30        
 His Ile Ala Gln Asp Ile Ala Ser Ile Arg Thr Pro Asp Val Ser Ser
          35                  40                  45            
 Gln Leu Lys Glu Arg Phe Val Lys Tyr Cys Glu Glu His Gly Ile Asp
      50                  55                  60                
 Lys Glu Asn Ile Phe Asp Leu Thr Lys Val Glu Leu Arg Asp Glu Gly
  65                  70                  75                  80
 Gly Gly His Trp Val Arg Gly Ser Trp Ile Gly Pro Phe Arg Ser Ala
                  85                  90                  95    
 Pro Val Ser Arg Gly Ala Leu Glu Asn Ala Leu Ala Gly Ser Gln Gly
             100                 105                 110        
 Leu Ser Asn Ala Leu Leu Trp Leu Val Ser Pro Ala Gly Glu Arg Tyr
         115                 120                 125            
 Pro Ala Ser Gly Gln Ile Pro Gly Ala Pro Gly Gly Arg Leu Arg Ala
     130                 135                 140                
 Ser Gln Ala Leu Pro Ala Ala Ala Ala Arg Ala Gln Phe Arg Lys Ser
 145                 150                 155                 160
 Gln Val Ser Ser Gly Ala Gln Ala Glu Ala Ser Ser Lys Arg Ile Lys
                 165                 170                 175    
 Val Phe Gly Leu Phe Ala Val Ala Ser Gly Lys Ile Lys Asn Gly Val
             180                 185                 190        
 Gly Glu Pro Gly Leu Gly Trp Val Lys His Val Ser Pro Lys Val Thr
         195                 200                 205            
 Leu Ala Arg Lys Pro Phe Asp Pro His Gln Arg Gly His Met Ser Pro
     210                 215                 220                
 Glu Val Thr Cys Pro Arg Arg Gly His Leu Pro Arg Phe His Pro Arg
 225                 230                 235                 240
 Thr Trp Val Glu Pro Val Val Ala Ser Ser Gln Val Ala Ala Ser Leu
                 245                 250                 255    
 Tyr Asp Ala Gly Leu Leu Leu Val Val Lys Ala Ser Tyr Gly Thr Gly
             260                 265                 270        
 Gly Ser Ser Asn His Ser Ala Ser Pro Ser Pro Arg Gly Ala Leu Glu
         275                 280                 285            
 Asp Gln Gln Gln Arg Ala Ile Ser Asn Phe Tyr Ile Ile Tyr Asn Leu
     290                 295                 300                
 Val Val Gly Leu Ser Pro Leu Leu Ser Ala Tyr Gly Leu Gly Trp Leu
 305                 310                 315                 320
 Ser Asp Arg Tyr His Arg Lys Ile Ser Ile Cys Met Ser Leu Leu Gly
                 325                 330                 335    
 Phe Leu Leu Ser Arg Leu Gly Leu Leu Leu Lys Val Leu Leu Asp Trp
             340                 345                 350        
 Pro Val Glu Val Leu Tyr Gly Ala Ala Ala Leu Asn Gly Leu Phe Gly
         355                 360                 365            
 Gly Phe Ser Ala Phe Trp Ser Gly Val Met Ala Leu Gly Ser Leu Gly
     370                 375                 380                
 Ser Ser Glu Gly Arg Arg Ser Val Arg Leu Ile Leu Ile Asp Leu Met
 385                 390                 395                 400
 Leu Gly Leu Ala Gly Phe Cys Gly Ser Met Ala Ser Gly His Leu Phe
                 405                 410                 415    
 Lys Gln Met Ala Gly His Ser Gly Gln Gly Leu Ile Leu Thr Ala Cys
             420                 425                 430        
 Ser Val Ser Cys Ala Ser Phe Ala Leu Leu Tyr Ser Leu Leu Val Leu
         435                 440                 445            
 Lys Val Pro Glu Ser Val Ala Lys Pro Ser Gln Glu Leu Pro Ala Val
     450                 455                 460                
 Asp Thr Val Ser Gly Thr Val Gly Thr Tyr Arg Thr Leu Asp Pro Asp
 465                 470                 475                 480
 Gln Leu Asp Gln Gln Tyr Ala Val Gly His Pro Pro Ser Pro Gly Lys
                 485                 490                 495    
 Ala Lys Pro His Lys Thr Thr Ile Ala Leu Leu Phe Val Gly Ala Ile
             500                 505                 510        
 Ile Tyr Asp Leu Ala Val Val Gly Thr Val Asp Val Ile Pro Leu Phe
         515                 520                 525            
 Val Leu Arg Glu Pro Leu Gly Trp Asn Gln Val Gln Val Gly Tyr Gly
     530                 535                 540                
 Met Ala Ala Gly Tyr Thr Ile Phe Ile Thr Ser Phe Leu Gly Val Leu
 545                 550                 555                 560
 Val Phe Ser Arg Cys Phe Arg Asp Thr Thr Met Ile Met Ile Gly Met
                 565                 570                 575    
 Val Ser Phe Gly Ser Gly Ala Leu Leu Leu Ala Phe Val Lys Glu Thr
             580                 585                 590        
 Tyr Met Phe Tyr Ile Ala Arg Ala Val Met Leu Phe Ala Leu Ile Pro
         595                 600                 605            
 Val Thr Thr Ile Arg Ser Ala Met Ser Lys Leu Ile Lys Gly Ser Ser
     610                 615                 620                
 Tyr Gly Lys Val Phe Val Ile Leu Gln Leu Ser Leu Ala Leu Thr Gly
 625                 630                 635                 640
 Val Val Thr Ser Thr Leu Tyr Asn Lys Ile Tyr Gln Leu Thr Met Asp
                 645                 650                 655    
 Met Phe Val Gly Ser Cys Phe Ala Leu Ser Ser Phe Leu Ser Phe Leu
             660                 665                 670        
 Ala Ile Ile Pro Ile Arg Ala Leu Cys Ser Val Arg Leu Lys Ser Pro
         675                 680                 685            
 Ser Arg Trp Thr Val
     690            



      <210> 1750
      <211> 1964
      <212> PRT
      <213> Homo sapiens


      <400> 1750
 Met Val Ala Gly Val Tyr Cys Leu Val Val Ala Val Ile Phe Ala Thr
   1               5                  10                  15    
 Ile Lys Thr Val Asn Tyr Arg Leu His Ala Met Phe Asp Gln Gly Glu
              20                  25                  30        
 Ile Val Glu Lys Arg Ser Ser Thr Met Gly Glu Leu Glu Glu Glu Pro
          35                  40                  45            
 Ala Gln Gly Asp Ser Asn Pro Pro Arg Asp Pro Gly Val Glu Met Thr
      50                  55                  60                
 Val Phe Arg Lys Val Ser Ser Thr Pro Pro Val Arg Cys Ser Ser Gln
  65                  70                  75                  80
 His Ser Val Phe Gly Phe Asn Gln Val Ser Glu Leu Leu Pro Arg Met
                  85                  90                  95    
 Glu Asp Ser Gly Pro Leu Arg Asp Ile Lys Glu Leu Val Arg Glu Gln
             100                 105                 110        
 Gly Ser Asn Asn Val Ile Val Thr Ser Ala Asp Arg Glu Met Leu Lys
         115                 120                 125            
 Leu Ser Ser Gln Glu Lys Leu Ile Gly Asp Leu Pro Gln Thr Pro Pro
     130                 135                 140                
 Gly Ala Val Pro Asp Pro Ser Leu Ala Ser Thr Asp Ser Ser Glu Pro
 145                 150                 155                 160
 Ser Pro Leu Ala Gly Asp Gly Ala Pro Trp Ser Gly Ser Ser Met Ala
                 165                 170                 175    
 Asp Thr Pro Met Ser Pro Leu Leu Lys Gly Ser Leu Ser Gln Glu Leu
             180                 185                 190        
 Ser Lys Ser Phe Leu Thr Leu Thr Gln Pro Asp Arg Ala Leu Val Arg
         195                 200                 205            
 Thr Ser Ser Arg Arg Glu Gln Arg Arg Gly Ala Gly Gly Tyr Gln Pro
     210                 215                 220                
 Leu Asp Arg Arg Gly Ser Gly Glu Pro Thr Pro Gln Lys Ala Gly Ser
 225                 230                 235                 240
 Ser Asp Ser Cys Phe Ser Gly Thr Asp Arg Glu Thr Leu Ser Ser Phe
                 245                 250                 255    
 Lys Ser Glu Lys Thr Asn Ser Thr His Leu Asp Ser Pro Pro Gly Gly
             260                 265                 270        
 Pro Ala Pro Glu Gly Ser Asp Thr Asp Pro Pro Ser Glu Ala Glu Leu
         275                 280                 285            
 Pro Ala Ser Pro Asp Ala Gly Val Pro Ser Asp Asp Thr Leu Arg Ser
     290                 295                 300                
 Phe Asp Thr Val Ile Gly Ala Gly Thr Pro Pro Gly Leu Ala Glu Pro
 305                 310                 315                 320
 Leu Leu Val Val Arg Pro Lys Asp Leu Ala Leu Leu Arg Pro Ser Lys
                 325                 330                 335    
 Arg Gln Pro Pro Leu Arg Arg His Ser Pro Pro Gly Arg Ala Pro Arg
             340                 345                 350        
 Arg Pro Leu Leu Glu Gly Gly Gly Phe Phe Glu Asp Glu Asp Thr Ser
         355                 360                 365            
 Glu Gly Ser Glu Leu Ser Pro Ala Ser Ser Leu Arg Ser Gln Arg Arg
     370                 375                 380                
 Tyr Ser Thr Asp Ser Ser Ser Ser Thr Ser Cys Tyr Ser Pro Glu Ser
 385                 390                 395                 400
 Ser Arg Gly Ala Ala Gly Gly Pro Arg Lys Arg Arg Ala Pro His Gly
                 405                 410                 415    
 Ala Glu Glu Gly Thr Ala Val Pro Pro Lys Arg Pro Tyr Gly Thr Gln
             420                 425                 430        
 Arg Thr Pro Ser Thr Ala Ser Ala Lys Thr His Ala Arg Val Leu Ser
         435                 440                 445            
 Met Asp Gly Ala Gly Gly Asp Val Leu Arg Pro Pro Leu Ala Gly Cys
     450                 455                 460                
 Lys Ala Glu Leu Glu Ala Gln Val Gly Val Glu Gln Ala Ala Ser Glu
 465                 470                 475                 480
 Pro Val Val Leu Pro Ala Glu Ala Arg Arg Gly Pro Ala Ala Asn Gln
                 485                 490                 495    
 Pro Gly Trp Arg Gly Glu Leu Gln Glu Glu Gly Ala Val Gly Gly Ala
             500                 505                 510        
 Ala Glu Glu Thr Gly Arg Arg Asp Arg Ser Ser Ser Val Arg Arg Thr
         515                 520                 525            
 Gln Ala Ile Arg Arg Arg His Asn Ala Gly Ser Asn Pro Thr Pro Pro
     530                 535                 540                
 Ala Ser Val Met Gly Ser Pro Pro Ser Ser Leu Gln Glu Ala Gln Arg
 545                 550                 555                 560
 Gly Arg Ala Ala Ser His Ser Arg Ala Leu Thr Leu Pro Ser Ala Leu
                 565                 570                 575    
 His Phe Ala Ser Ser Leu Leu Leu Thr Arg Ala Gly Ala Asn Val His
             580                 585                 590        
 Glu Ala Cys Thr Phe Asp Asp Thr Ser Glu Gly Ala Val His Tyr Phe
         595                 600                 605            
 Tyr Asp Glu Ser Gly Val Arg Arg Ser Tyr Thr Phe Gly Leu Ala Gly
     610                 615                 620                
 Gly Gly Tyr Glu Asn Pro Val Gly Gln Gln Gly Glu Gln Thr Ala Asn
 625                 630                 635                 640
 Gly Ala Trp Asp Arg His Ser His Ser Ser Ser Phe His Ser Ala Asp
                 645                 650                 655    
 Val Pro Glu Ala Thr Gly Gly Leu Asn Leu Leu Gln Pro Arg Pro Val
             660                 665                 670        
 Val Leu Gln Gly Met Gln Val Arg Arg Val Pro Leu Glu Ile Pro Glu
         675                 680                 685            
 Phe Asp Leu Leu Asp Gln Asp Ser Leu His Glu Ser Gln Glu Gln Thr
     690                 695                 700                
 Leu Met Glu Glu Ala Pro Pro Arg Ala Gln His Ser Tyr Lys Tyr Trp
 705                 710                 715                 720
 Leu Leu Pro Gly Arg Trp Thr Ser Val Arg Tyr Glu Arg Leu Ala Leu
                 725                 730                 735    
 Leu Ala Leu Leu Asp Arg Thr Arg Gly Val Leu Glu Asn Ile Phe Gly
             740                 745                 750        
 Val Gly Leu Ser Ser Leu Val Ala Phe Leu Gly Tyr Leu Leu Leu Leu
         755                 760                 765            
 Lys Gly Phe Phe Thr Asp Ile Trp Val Phe Gln Phe Cys Leu Val Ile
     770                 775                 780                
 Ala Ser Cys Gln Tyr Ser Leu Leu Lys Ser Val Gln Pro Asp Ala Ala
 785                 790                 795                 800
 Ser Pro Met His Gly His Asn Trp Val Ile Ala Tyr Ser Arg Pro Val
                 805                 810                 815    
 Tyr Phe Cys Ile Cys Cys Leu Leu Ile Trp Leu Leu Asp Ala Leu Gly
             820                 825                 830        
 Ser Ala Gln Pro Phe Pro Pro Val Ser Leu Tyr Gly Leu Thr Leu Phe
         835                 840                 845            
 Ser Ala Ser Phe Phe Phe Cys Ala Arg Asp Val Ala Thr Val Phe Thr
     850                 855                 860                
 Leu Cys Phe Pro Phe Val Phe Leu Leu Gly Leu Leu Pro Gln Val Asn
 865                 870                 875                 880
 Thr Cys Leu Met Tyr Leu Leu Glu Gln Ile Asp Met His Gly Phe Gly
                 885                 890                 895    
 Gly Thr Ala Ala Thr Ser Pro Leu Thr Ala Val Phe Ser Leu Ser Arg
             900                 905                 910        
 Ser Leu Leu Ala Ala Ala Leu Leu Tyr Gly Phe Cys Leu Gly Ala Ile
         915                 920                 925            
 Lys Thr Pro Trp Pro Glu Gln His Val Pro Val Leu Phe Ser Val Phe
     930                 935                 940                
 Cys Gly Leu Leu Val Ala Leu Ser Tyr His Leu Ser Arg Gln Ser Ser
 945                 950                 955                 960
 Asp Pro Thr Val Leu Trp Ser Leu Ile Arg Ser Lys Leu Phe Pro Glu
                 965                 970                 975    
 Leu Glu Glu Arg Ser Leu Glu Thr Ala Arg Ala Glu Pro Pro Asp Pro
             980                 985                 990        
 Leu Pro Asp Lys Met Arg Gln Ser Val Arg Glu Val Leu His Ser Asp
         995                1000                1005            
 Leu Val Met Cys Val Val Ile Ala Val Leu Thr Phe Ala Ile Ser Ala
    1010                1015                1020                
 Ser Thr Val Phe Ile Ala Leu Lys Ser Val Leu Gly Phe Val Leu Tyr
1025                1030                1035                1040
 Ala Leu Ala Gly Ala Val Gly Phe Phe Thr His Tyr Leu Leu Pro Gln
                1045                1050                1055    
 Leu Arg Lys Gln Leu Pro Trp Phe Cys Leu Ser Gln Pro Val Leu Lys
            1060                1065                1070        
 Pro Leu Glu Tyr Ser Gln Tyr Glu Val Arg Gly Ala Ala Gln Val Met
        1075                1080                1085            
 Trp Phe Glu Lys Leu Tyr Ala Gly Leu Gln Cys Val Glu Lys Tyr Leu
    1090                1095                1100                
 Ile Tyr Pro Ala Val Val Leu Asn Ala Leu Thr Val Asp Ala His Thr
1105                1110                1115                1120
 Val Val Ser His Pro Asp Lys Tyr Cys Phe Tyr Cys Arg Ala Leu Leu
                1125                1130                1135    
 Met Thr Val Ala Gly Leu Lys Leu Leu Arg Ser Ala Phe Cys Cys Pro
            1140                1145                1150        
 Pro Gln Gln Tyr Leu Thr Leu Ala Phe Thr Val Leu Leu Phe His Phe
        1155                1160                1165            
 Asp Tyr Pro Arg Leu Ser Gln Gly Phe Leu Leu Asp Tyr Phe Leu Met
    1170                1175                1180                
 Ser Leu Leu Cys Ser Lys Leu Trp Asp Leu Leu Tyr Lys Leu Arg Phe
1185                1190                1195                1200
 Val Leu Thr Tyr Ile Ala Pro Trp Gln Ile Thr Trp Gly Ser Ala Phe
                1205                1210                1215    
 His Ala Phe Ala Gln Pro Phe Ala Cys Ala Thr Tyr Pro Ala Cys Val
            1220                1225                1230        
 Trp Ala Leu Leu Ser Gly Leu Phe Ser Thr Pro Leu Asn Pro Leu Leu
        1235                1240                1245            
 Gly Ser Ala Val Phe Ile Met Ser Tyr Ala Arg Pro Leu Lys Phe Trp
    1250                1255                1260                
 Glu Arg Asp Tyr Lys Glu Ser Met Ser Arg Val His Pro Leu Phe Thr
1265                1270                1275                1280
 Phe Leu Ala Asn Arg Leu Val Ala Leu Ser Leu Asn Ser Thr Lys Arg
                1285                1290                1295    
 Val Asp His Ser Asn Thr Arg Leu Val Thr Gln Leu Asp Arg Asn Pro
            1300                1305                1310        
 Gly Ala Asp Asp Asn Asn Leu Asn Ser Ile Phe Tyr Glu His Leu Thr
        1315                1320                1325            
 Arg Ser Leu Gln His Thr Leu Cys Gly Asp Leu Val Leu Gly Arg Trp
    1330                1335                1340                
 Gly Asn Tyr Gly Pro Gly Asp Cys Phe Val Leu Ala Ser Asp Tyr Leu
1345                1350                1355                1360
 Asn Ala Leu Val His Leu Ile Glu Val Gly Asn Gly Leu Val Thr Phe
                1365                1370                1375    
 Gln Leu Arg Gly Leu Glu Phe Arg Gly Thr Tyr Cys Gln Gln Arg Glu
            1380                1385                1390        
 Val Glu Ala Ile Thr Glu Gly Val Glu Glu Asp Glu Gly Cys Cys Cys
        1395                1400                1405            
 Cys Glu Pro Gly His Leu Pro Arg Val Leu Ser Phe Asn Ala Ala Phe
    1410                1415                1420                
 Gly Gln Arg Trp Leu Ala Trp Glu Val Thr Ala Ser Lys Tyr Val Leu
1425                1430                1435                1440
 Glu Gly Tyr Ser Ile Ser Asp Asn Asn Ala Ala Ser Met Leu Gln Val
                1445                1450                1455    
 Phe Asp Leu Arg Lys Ile Leu Ile Thr Tyr Tyr Val Lys Ser Ile Ile
            1460                1465                1470        
 Tyr Tyr Val Ser Arg Ser Pro Lys Leu Glu Val Trp Leu Ser His Glu
        1475                1480                1485            
 Gly Ile Thr Ala Ala Leu Arg Pro Val Arg Val Pro Gly Tyr Ala Asp
    1490                1495                1500                
 Ser Asp Pro Thr Phe Ser Leu Ser Val Asp Glu Asp Tyr Asp Leu Arg
1505                1510                1515                1520
 Leu Ser Gly Leu Ser Leu Pro Ser Phe Cys Ala Val His Leu Glu Trp
                1525                1530                1535    
 Ile Gln Tyr Cys Ala Ser Arg Arg Ser Gln Pro Val Asp Gln Asp Trp
            1540                1545                1550        
 Asn Ser Pro Leu Val Thr Leu Cys Phe Gly Leu Cys Val Leu Gly Arg
        1555                1560                1565            
 Arg Ala Leu Gly Thr Ala Ser His Ser Met Ser Ala Ser Leu Glu Pro
    1570                1575                1580                
 Phe Leu Tyr Gly Leu His Ala Leu Phe Lys Gly Asp Phe Arg Ile Thr
1585                1590                1595                1600
 Ser Pro Arg Asp Glu Trp Val Phe Ala Asp Met Asp Leu Leu His Arg
                1605                1610                1615    
 Val Val Ala Pro Gly Val Arg Met Ala Leu Lys Leu His Gln Asp His
            1620                1625                1630        
 Phe Thr Ser Pro Asp Glu Tyr Glu Glu Pro Ala Ala Leu Tyr Asp Ala
        1635                1640                1645            
 Ile Ala Ala Asn Glu Glu Arg Leu Val Ile Ser His Glu Gly Asp Pro
    1650                1655                1660                
 Ala Trp Arg Ser Ala Ile Leu Ser Asn Thr Pro Ser Leu Leu Ala Leu
1665                1670                1675                1680
 Arg His Val Leu Asp Asp Ala Ser Asp Glu Tyr Lys Ile Ile Met Leu
                1685                1690                1695    
 Asn Arg Arg His Leu Ser Phe Arg Val Ile Lys Val Asn Arg Glu Cys
            1700                1705                1710        
 Val Arg Gly Leu Trp Ala Gly Gln Gln Gln Glu Leu Val Phe Leu Arg
        1715                1720                1725            
 Asn Arg Asn Pro Glu Arg Gly Ser Ile Gln Asn Ala Lys Gln Ala Leu
    1730                1735                1740                
 Arg Asn Met Ile Asn Ser Ser Cys Asp Gln Pro Leu Gly Tyr Pro Ile
1745                1750                1755                1760
 Tyr Val Ser Pro Leu Thr Thr Ser Leu Ala Gly Ser His Pro Gln Leu
                1765                1770                1775    
 Arg Ala Leu Trp Gly Gly Pro Ile Ser Leu Gly Ala Ile Ala His Trp
            1780                1785                1790        
 Leu Leu Arg Thr Trp Glu Arg Leu His Lys Gly Cys Gly Ala Gly Cys
        1795                1800                1805            
 Asn Ser Gly Gly Asn Val Asp Asp Ser Asp Cys Ser Gly Gly Gly Gly
    1810                1815                1820                
 Leu Thr Ser Leu Ser Asn Asn Pro Pro Val Ala His Pro Thr Pro Glu
1825                1830                1835                1840
 Asn Thr Ala Glu Gly Pro Arg Thr Ser Arg Pro Pro Gly Pro Gly Leu
                1845                1850                1855    
 Leu Ser Ser Glu Gly Pro Ser Gly Lys Trp Ser Leu Gly Gly Arg Lys
            1860                1865                1870        
 Gly Leu Gly Gly Ser Asp Gly Glu Pro Ala Ser Gly Ser Pro Lys Gly
        1875                1880                1885            
 Gly Thr Pro Lys Ser Gln Ala Pro Leu Asp Leu Ser Leu Ser Leu Ser
    1890                1895                1900                
 Leu Ser Leu Ser Pro Asp Val Ser Thr Glu Ala Ser Pro Pro Arg Ala
1905                1910                1915                1920
 Ser Gln Asp Ile Pro Cys Leu Asp Ser Ser Ala Pro Glu Ser Gly Thr
                1925                1930                1935    
 Pro Met Gly Ala Leu Gly Asp Trp Pro Ala Pro Ile Glu Glu Arg Glu
            1940                1945                1950        
 Ser Pro Ala Ala Gln Pro Leu Leu Glu His Gln Tyr
        1955                1960                



      <210> 1751
      <211> 426
      <212> PRT
      <213> Homo sapiens


      <400> 1751
 Met Ser Tyr Arg Glu Val Lys Tyr Phe Ser Phe Pro Gly Glu Leu Leu
   1               5                  10                  15    
 Met Arg Met Leu Gln Met Leu Val Leu Pro Leu Ile Ile Ser Ser Leu
              20                  25                  30        
 Val Thr Val Cys Ile Pro Pro Gln Ser Leu Thr Ser Glu Glu Ile Phe
          35                  40                  45            
 Gly Val Thr Pro Val Phe Trp Lys Trp Gly Ala Gln Leu Leu Thr Cys
      50                  55                  60                
 Asn Leu Cys Gly Val Gly His Asp Val Ser Lys Arg Ala Ala Ser Ser
  65                  70                  75                  80
 Glu Pro Glu Ile Leu Ile Ser Ser Arg Leu Glu Glu Ile Phe Glu Lys
                  85                  90                  95    
 Phe Lys Glu Lys Asn Ala Val Glu Leu Gln Val Ser Ser Ala Asp Ile
             100                 105                 110        
 Met Val Ser Lys Arg Val Ser Tyr Leu Val Asn Ser Asp Leu Glu Met
         115                 120                 125            
 Ser Asn Thr Asp Thr Gln Val Asn Gln Asp Val Ser Leu Trp Val Ser
     130                 135                 140                
 Asp Gln Val Ser Pro Ser Gln Asp Ile Pro Gln Pro Pro Leu Trp Leu
 145                 150                 155                 160
 Ser Cys Glu Val Val Gly Gly Lys Glu Ser Phe Ala Met Leu Phe Leu
                 165                 170                 175    
 Glu Arg Phe Thr Asp Ser Ile Leu Gln Leu Ile Phe Gly Gly Met Pro
             180                 185                 190        
 Thr Lys Ala Met Ala Cys Asn Ser Ala Val Gly His Glu Val Ile Gln
         195                 200                 205            
 Lys Ala Ile Ala Gln Leu Gln Asp Gly Glu Gln Leu Ser Leu Ala Ala
     210                 215                 220                
 Val His Asp Lys Gly Gln Tyr Ala Glu Val Glu Asn Ser Gly Gln Glu
 225                 230                 235                 240
 His Gln Arg Arg Val Gly Val Arg Thr Glu Gln His His Lys Ile Glu
                 245                 250                 255    
 Gly Glu Arg Glu Lys Ser Ile Ser Glu Glu Glu Asn Thr Ala Ala Trp
             260                 265                 270        
 Tyr Ser Leu Val Pro Arg Asp Ile Arg Arg Ile Val Leu Thr Leu Leu
         275                 280                 285            
 Ala Gly Ser Thr Gly Arg Glu Pro Glu Glu Leu Gln Ala Leu Val Val
     290                 295                 300                
 Thr Ser Ser Gly Thr His Gly Lys Glu Arg Met Ala Ala Leu Asp Ser
 305                 310                 315                 320
 Lys Ala Ser Gly Lys Met Gly Met Arg Ala Val Val Tyr Tyr Met Thr
                 325                 330                 335    
 Thr Thr Ile Ile Ala Val Val Ile Gly Ile Ile Ile Val Ile Ile Ile
             340                 345                 350        
 His Pro Gly Lys Gly Thr Lys Glu Asn Met His Arg Glu Gly Lys Ile
         355                 360                 365            
 Val Arg Val Thr Ala Ala Asp Ala Phe Leu Asp Leu Ile Arg Asn Met
     370                 375                 380                
 Phe Pro Pro Asn Leu Val Glu Ala Cys Phe Lys Gln Ser Thr Lys His
 385                 390                 395                 400
 Leu Met Asp Ser Lys Gly Glu Pro Lys Gln Lys Gly Met Ala Ser Ser
                 405                 410                 415    
 Phe Met Glu Ile Leu Leu Tyr Ala Lys His
             420                 425    



      <210> 1752
      <211> 156
      <212> PRT
      <213> Homo sapiens


      <400> 1752
 Met Leu Leu Val Ile Ile Val Ser Val Gly Val Ile Thr Ile Val Val
   1               5                  10                  15    
 Val Val Ile Ile Ala Val Phe Cys Thr Arg Arg Thr Thr Ser His Gln
              20                  25                  30        
 Lys Lys Lys Arg Ala Ala Cys Lys Ser Val Asn Gly Ser His Lys Tyr
          35                  40                  45            
 Lys Gly Asn Ser Lys Asp Val Lys Pro Pro Asp Leu Trp Ile His His
      50                  55                  60                
 Glu Arg Leu Glu Leu Lys Pro Ile Asp Lys Ser Pro Asp Pro Asn Pro
  65                  70                  75                  80
 Ile Met Thr Asp Thr Pro Ile Pro Arg Asn Ser Gln Asp Ile Thr Pro
                  85                  90                  95    
 Val Asp Asn Ser Met Asp Ser Asn Ile His Gln Arg Arg Asn Ser Tyr
             100                 105                 110        
 Arg Ala Gly Phe Gln Leu Ala Leu Trp Tyr Ser Glu His Ser Trp Ser
         115                 120                 125            
 Gly Gly Ser Tyr Arg His Pro Val Lys Tyr Gly Gly Gln His Cys Asp
     130                 135                 140                
 Ile His Ile Asp Ser Ala Gly Thr Leu Val Met Leu
 145                 150                 155    



      <210> 1753
      <211> 697
      <212> PRT
      <213> Homo sapiens


      <400> 1753
 Met Val Gly Gln Arg Ala Gln His Ser Pro Val Ser Leu Leu Leu Leu
   1               5                  10                  15    
 Ile His Leu Cys Leu Leu His Leu Arg Ala Ser Gly Gln Pro His Pro
              20                  25                  30        
 Thr Pro Glu Ala Pro Val Glu Glu Val Val Ser Val Gln Gly Val Arg
          35                  40                  45            
 Gly Gly Ser Val Glu Leu Ala Cys Gly Ser Gly Pro Ala Pro Leu Leu
      50                  55                  60                
 Val Leu Trp Ser Phe Thr Pro Leu Gly Ser Leu Val Pro Arg Pro Val
  65                  70                  75                  80
 Ala Val Thr Asp Gly Ala Met Ser Lys Val Glu Ala Ile Ala Ser Ala
                  85                  90                  95    
 Leu Gly Val Val Ser Leu Arg Asn Ser Ser Leu Val Leu Gly Glu Leu
             100                 105                 110        
 His Glu Gly Ala Arg Gly His Phe Leu Cys Gln Val Leu His Val Ala
         115                 120                 125            
 Gly Gly Gln Leu His Ala Ala Tyr Ser His Leu Thr Leu Ala Val Leu
     130                 135                 140                
 Val Pro Val Ser Lys Pro Gln Val Arg Leu Ser Asn Pro Ser Pro Val
 145                 150                 155                 160
 Glu Gly Ala Ser Val Val Ala Thr Cys Ala Val Arg Glu Gly Thr Glu
                 165                 170                 175    
 Pro Val Thr Phe Ala Trp Gln His Arg Ala Pro Arg Gly Leu Gly Glu
             180                 185                 190        
 Ala Leu Val Gly Val Thr Glu Pro Leu Phe Gln Leu Asp Pro Val Asn
         195                 200                 205            
 Arg Thr His Leu Gly Trp Tyr Met Cys Ser Ala Ser Asn Ser Val Asn
     210                 215                 220                
 Arg Leu Ser Ser Asp Gly Ala Phe Leu Asp Val Ile Tyr Gly Pro Asp
 225                 230                 235                 240
 Lys Pro Val Ile Thr Met Glu Pro Leu Gly Leu Thr Glu Glu Gly Phe
                 245                 250                 255    
 Trp Ala Ser Glu Arg Glu Glu Val Thr Leu Ser Cys Leu Ala Ala Ser
             260                 265                 270        
 Asn Pro Pro Ser His Tyr Val Trp Leu Arg Asp His Thr Gln Val His
         275                 280                 285            
 Thr Gly Pro Thr Tyr Val Ile Ala Arg Ala Gly Arg Val His Thr Gly
     290                 295                 300                
 Leu Tyr Thr Cys Leu Ala Arg Asn Ser Tyr Leu Asp Thr Arg Thr Gln
 305                 310                 315                 320
 Thr Thr Val Gln Leu Thr Ile Tyr Trp Glu Pro Leu Gly Arg Pro Thr
                 325                 330                 335    
 Cys Trp Ser Thr Ala Thr Met Gly Asp Gln Phe Ile Met Leu Ser Cys
             340                 345                 350        
 Glu Trp Pro Gly Gly Glu Pro Pro Ala Thr Leu Gly Trp Leu Asp Glu
         355                 360                 365            
 Gln Gln Gln Pro Leu Gly Gly Ser Ser Ser Ser Met Ala Val His Leu
     370                 375                 380                
 Leu Gln Ala Gln Glu Asp Leu Ala Gly Arg Glu Phe Thr Cys Arg Gly
 385                 390                 395                 400
 Thr His Leu Leu Arg Thr Pro Asp Pro His Cys His Leu Gln Leu Glu
                 405                 410                 415    
 Ala Pro Gln Leu Asp Val Ala Glu Pro Arg Val Ser Val Leu Glu Gly
             420                 425                 430        
 Gly Glu Ala Trp Leu Glu Cys Ser Leu Arg Gly Gly Thr Pro Pro Ala
         435                 440                 445            
 Gln Leu Leu Trp Leu Gly Pro Gln Gln Gln Lys Val Asp Pro Gly Thr
     450                 455                 460                
 Ser Gly Phe Met Leu His Pro Glu Gly Ala Gln Leu Arg Leu Gly Ile
 465                 470                 475                 480
 Tyr Asp Ala Asp Pro Ala His His Arg Gly Thr Tyr Gln Cys Val Ala
                 485                 490                 495    
 Arg Asn Ala Val Gly Asn Ser Ser Gln Ser Val Leu Leu Glu Val Leu
             500                 505                 510        
 Arg Tyr Pro Ala Pro Pro Asn Val Thr Ile Ser Arg Leu Thr Tyr Gly
         515                 520                 525            
 Arg His Arg Arg Glu Val Gln Leu Gln Trp Ala Ile Leu Gly Pro Gly
     530                 535                 540                
 Asn Leu Thr Gly Phe Leu Val Gln Arg Lys Ala Ser Ala Leu Gly Pro
 545                 550                 555                 560
 Gly Ala Gly Ala Trp Glu Thr Ala Ala Ser Asp Ile Glu Pro Glu Ser
                 565                 570                 575    
 Arg Gly Arg Arg Leu Gly Gly Leu Asp Pro Gly Val Leu Tyr Ala Phe
             580                 585                 590        
 Arg Ile Leu Ala Leu Asn His His Thr Ala Gly His Pro Ser Glu Val
         595                 600                 605            
 Lys Ile Pro Ala Asp Pro Pro Phe Ser Ala Tyr Pro Ala Val Leu Gly
     610                 615                 620                
 Ala Ala Gly Thr Gly Met Val Val Ala Thr Val Ala Ser Leu Leu Val
 625                 630                 635                 640
 Phe Gln Tyr Ala Ala Arg His Pro Glu Thr Phe Pro Arg Ser Lys Gly
                 645                 650                 655    
 Thr Asn Arg Gly Val Pro Glu Lys Met Leu Arg His Arg Gln Leu Thr
             660                 665                 670        
 Asn Ile Thr Asp Ala Ala Val Val Arg Leu Gln Glu Ser Gln Pro Thr
         675                 680                 685            
 Arg Tyr Gly Ala Glu Val Leu Gln Met
     690                 695        



      <210> 1754
      <211> 126
      <212> PRT
      <213> Homo sapiens


      <400> 1754
 Met Leu Cys Leu Pro Cys His Ser Thr Phe His Met Ala His Phe Leu
   1               5                  10                  15    
 Phe Ser Leu Leu Leu Cys Val Gln Met Cys Asp Gly Ser His Leu Ala
              20                  25                  30        
 Ser Thr Leu Arg Tyr Cys Met Thr Val Ser Gly Thr Val Val Leu Val
          35                  40                  45            
 Ala Gly Thr Leu Cys Phe Ala Trp Trp Ser Glu Gly Asp Ala Thr Ala
      50                  55                  60                
 Gln Pro Gly Gln Leu Ala Pro Pro Thr Glu Tyr Pro Val Pro Glu Gly
  65                  70                  75                  80
 Pro Ser Pro Leu Leu Arg Ser Val Ser Phe Val Cys Cys Gly Ala Gly
                  85                  90                  95    
 Gly Leu Leu Leu Leu Ile Gly Leu Met Leu Glu Val Glu Pro Ile Gly
             100                 105                 110        
 Cys Gly Cys Asp Gly Gly Gly Glu Val Gly Asp Gly Ala Cys
         115                 120                 125    



      <210> 1755
      <211> 393
      <212> PRT
      <213> Homo sapiens


      <400> 1755
 Met Val Leu His Glu Thr Phe Pro Lys His Thr Phe Leu Met Asn Gly
   1               5                  10                  15    
 Leu Ile Gln Gly Val Lys Gly Leu Leu Ser Phe Leu Ser Ala Pro Leu
              20                  25                  30        
 Ile Gly Ala Leu Ser Asp Val Trp Gly Arg Lys Ser Phe Leu Leu Leu
          35                  40                  45            
 Thr Val Phe Phe Thr Cys Ala Pro Ile Pro Leu Met Lys Ile Ser Pro
      50                  55                  60                
 Trp Trp Tyr Phe Ala Val Ile Ser Val Ser Gly Val Phe Ala Val Thr
  65                  70                  75                  80
 Phe Ser Val Val Phe Ala Tyr Val Ala Asp Ile Thr Gln Glu His Glu
                  85                  90                  95    
 Arg Ser Met Ala Tyr Gly Leu Val Ser Ala Thr Phe Ala Ala Ser Leu
             100                 105                 110        
 Val Thr Ser Pro Ala Ile Gly Ala Tyr Leu Gly Arg Val Tyr Gly Asp
         115                 120                 125            
 Ser Leu Val Val Val Leu Ala Thr Ala Ile Ala Leu Leu Asp Ile Cys
     130                 135                 140                
 Phe Ile Leu Val Ala Val Pro Glu Ser Leu Pro Glu Lys Met Arg Pro
 145                 150                 155                 160
 Ala Ser Trp Gly Ala Pro Ile Ser Trp Glu Gln Ala Asp Pro Phe Ala
                 165                 170                 175    
 Ile Met Lys Phe Ser Pro Glu Ser Val Ala Ala Phe Ile Ala Val Leu
             180                 185                 190        
 Gly Ile Leu Ser Ile Ile Ala Gln Thr Ile Val Leu Ser Leu Leu Met
         195                 200                 205            
 Arg Ser Ile Gly Asn Lys Asn Thr Ile Leu Leu Gly Leu Gly Phe Gln
     210                 215                 220                
 Ile Leu Gln Leu Ala Trp Tyr Gly Phe Gly Ser Glu Pro Trp Met Met
 225                 230                 235                 240
 Trp Ala Ala Gly Ala Val Ala Ala Met Ser Ser Ile Thr Phe Pro Ala
                 245                 250                 255    
 Val Ser Ala Leu Val Ser Arg Thr Ala Asp Ala Asp Gln Gln Gly Val
             260                 265                 270        
 Val Gln Gly Met Ile Thr Gly Ile Arg Gly Leu Cys Asn Gly Leu Gly
         275                 280                 285            
 Pro Ala Leu Tyr Gly Phe Ile Phe Tyr Ile Phe His Val Glu Leu Lys
     290                 295                 300                
 Glu Leu Pro Ile Thr Gly Thr Asp Leu Gly Thr Asn Thr Ser Pro Gln
 305                 310                 315                 320
 His His Phe Glu Gln Asn Ser Ile Ile Pro Gly Pro Pro Phe Leu Phe
                 325                 330                 335    
 Gly Ala Cys Ser Val Leu Leu Ala Leu Leu Val Ala Leu Phe Ile Pro
             340                 345                 350        
 Glu His Thr Asn Leu Ser Leu Arg Ser Ser Ser Trp Arg Lys His Cys
         355                 360                 365            
 Gly Ser His Ser His Pro His Asn Thr Gln Ala Pro Gly Glu Ala Lys
     370                 375                 380                
 Glu Pro Leu Leu Gln Asp Thr Asn Val
 385                 390            



      <210> 1756
      <211> 256
      <212> PRT
      <213> Homo sapiens


      <400> 1756
 Met Ser Pro Leu Leu Gly Leu Arg Ser Glu Leu Gln Asp Thr Cys Thr
   1               5                  10                  15    
 Ser Leu Gly Leu Met Leu Ser Val Val Leu Leu Met Gly Leu Ala Arg
              20                  25                  30        
 Val Val Ala Arg Gln Gln Leu His Arg Pro Val Ala His Ala Phe Val
          35                  40                  45            
 Leu Glu Phe Leu Ala Thr Phe Gln Leu Cys Cys Cys Thr His Glu Leu
      50                  55                  60                
 Gln Leu Leu Ser Glu Gln His Pro Ala His Pro Thr Trp Thr Leu Thr
  65                  70                  75                  80
 Leu Val Tyr Phe Phe Ser Leu Val His Gly Leu Thr Leu Val Gly Thr
                  85                  90                  95    
 Ser Ser Asn Pro Cys Gly Val Met Met Gln Met Met Leu Gly Gly Met
             100                 105                 110        
 Ser Pro Glu Thr Gly Ala Val Arg Leu Leu Ala Gln Leu Val Ser Ala
         115                 120                 125            
 Leu Cys Ser Arg Tyr Cys Thr Ser Ala Leu Trp Ser Leu Gly Leu Thr
     130                 135                 140                
 Gln Tyr His Val Ser Glu Arg Ser Phe Ala Cys Lys Asn Pro Ile Arg
 145                 150                 155                 160
 Val Asp Leu Leu Lys Ala Val Ile Thr Glu Ala Val Cys Ser Phe Leu
                 165                 170                 175    
 Phe His Ser Ala Leu Leu His Phe Gln Glu Val Arg Thr Lys Leu Arg
             180                 185                 190        
 Ile His Leu Leu Ala Ala Leu Ile Thr Phe Leu Val Tyr Ala Gly Leu
         195                 200                 205            
 Ser Phe Ser Pro Asn Thr Trp His Phe Gln Ser Leu Tyr Asp Met Arg
     210                 215                 220                
 Leu Leu His Arg Ala Phe Thr Met Leu Leu Ser Ile Val Lys Leu Gln
 225                 230                 235                 240
 Glu Glu Asp Leu Glu His Ser Phe Ser Asn Leu Arg Asp Pro Leu Val
                 245                 250                 255    





      <210> 1757
      <211> 799
      <212> PRT
      <213> Homo sapiens


      <400> 1757
 Met Pro Phe Thr Ser Gly Ala Ala Phe Leu Leu Arg Pro Ile Trp Leu
   1               5                  10                  15    
 Ala Glu Ala Phe Gly Asn Lys Asn Glu Ala Phe Ser Leu Ser Ala Pro
              20                  25                  30        
 Met Ala Arg Val Val His Tyr Val Asp Gln Pro Leu Pro Arg Cys Ser
          35                  40                  45            
 Arg Ala Leu Leu Thr Leu Gly Ala Gly Met Gln Arg Pro Cys Leu Arg
      50                  55                  60                
 Thr Ala Leu Gly Thr Ala Ser Gly Ser Pro Glu Gly Leu Ala Gly Leu
  65                  70                  75                  80
 Gly Ala Arg Ala Met Arg Gln Pro Pro Pro Pro Leu Arg Asp His Pro
                  85                  90                  95    
 Arg Pro Lys Arg Glu Pro Gln Arg Arg Phe Cys Ser Ser Leu Arg Arg
             100                 105                 110        
 Arg Pro Arg Thr Arg His Pro Thr Pro Ala Thr Pro Ser Gly Glu Asp
         115                 120                 125            
 Pro Pro Ala Arg Ala Ala Pro Ile Ala Pro Arg Pro Pro Ala Arg Pro
     130                 135                 140                
 Arg Leu Glu Arg Ala Leu Ser Leu Asp Asp Lys Gly Trp Arg Arg Arg
 145                 150                 155                 160
 Arg Phe Arg Gly Ser Gln Glu Asp Leu Glu Ala Arg Asn Gly Thr Ser
                 165                 170                 175    
 Pro Ser Arg Gly Ser Val Gln Ser Glu Gly Pro Gly Ala Pro Ala His
             180                 185                 190        
 Ser Cys Ser Pro Pro Cys Leu Ser Thr Ser Leu Gln Glu Ile Pro Lys
         195                 200                 205            
 Ser Arg Gly Val Leu Ser Ser Glu Arg Gly Ser Pro Ser Ser Gly Gly
     210                 215                 220                
 Asn Pro Leu Ser Gly Val Ala Ser Ser Ser Pro Asn Leu Pro His Arg
 225                 230                 235                 240
 Asp Ala Ala Val Ala Gly Ser Ser Pro Arg Leu Pro Ser Leu Leu Pro
                 245                 250                 255    
 Pro Arg Pro Pro Pro Ala Leu Ser Leu Asp Ile Ala Ser Asp Ser Leu
             260                 265                 270        
 Arg Thr Ala Asn Lys Val Asp Ser Asp Leu Ala Asp Tyr Lys Leu Arg
         275                 280                 285            
 Ala Gln Pro Leu Leu Val Arg Ala His Ser Ser Leu Gly Pro Gly Arg
     290                 295                 300                
 Pro Arg Ser Pro Leu Ala Cys Asp Asp Cys Ser Leu Arg Ser Ala Lys
 305                 310                 315                 320
 Ser Ser Phe Ser Leu Leu Ala Pro Ile Arg Ser Lys Asp Val Arg Ser
                 325                 330                 335    
 Arg Ser Tyr Leu Glu Gly Ser Leu Leu Ala Ser Gly Ala Leu Leu Gly
             340                 345                 350        
 Ala Asp Glu Leu Ala Arg Tyr Phe Pro Asp Arg Asn Val Ala Leu Phe
         355                 360                 365            
 Val Ala Thr Trp Asn Met Gln Gly Gln Lys Glu Leu Pro Pro Ser Leu
     370                 375                 380                
 Asp Glu Phe Leu Leu Pro Ala Glu Ala Asp Tyr Ala Gln Asp Leu Tyr
 385                 390                 395                 400
 Val Ile Gly Val Gln Glu Gly Cys Ser Asp Arg Arg Glu Trp Glu Thr
                 405                 410                 415    
 Arg Leu Gln Glu Thr Leu Gly Pro His Tyr Val Leu Leu Ser Ser Ala
             420                 425                 430        
 Ala His Gly Val Leu Tyr Met Ser Leu Phe Ile Arg Arg Asp Leu Ile
         435                 440                 445            
 Trp Phe Cys Ser Glu Val Glu Cys Ser Thr Val Thr Thr Arg Ile Val
     450                 455                 460                
 Ser Gln Ile Lys Thr Lys Gly Ala Leu Gly Ile Ser Phe Thr Phe Phe
 465                 470                 475                 480
 Gly Thr Ser Phe Leu Phe Ile Thr Ser His Phe Thr Ser Gly Asp Gly
                 485                 490                 495    
 Lys Val Ala Glu Arg Leu Leu Asp Tyr Thr Arg Thr Val Gln Ala Leu
             500                 505                 510        
 Val Leu Pro Arg Asn Val Pro Asp Thr Asn Pro Tyr Arg Ser Ser Ala
         515                 520                 525            
 Ala Asp Val Thr Thr Arg Phe Asp Glu Val Phe Trp Phe Gly Asp Phe
     530                 535                 540                
 Asn Phe Arg Leu Ser Gly Gly Arg Thr Val Val Asp Ala Leu Leu Cys
 545                 550                 555                 560
 Gln Gly Leu Val Val Asp Val Pro Ala Leu Leu Gln His Asp Gln Leu
                 565                 570                 575    
 Ile Arg Glu Met Arg Lys Gly Ser Ile Phe Lys Gly Phe Gln Glu Pro
             580                 585                 590        
 Asp Ile His Phe Leu Pro Ser Tyr Lys Phe Asp Ile Gly Lys Asp Thr
         595                 600                 605            
 Tyr Asp Ser Thr Ser Lys Gln Arg Thr Pro Ser Tyr Thr Ser Ala Ser
     610                 615                 620                
 Arg Ala Gly Ile Ser His Ser Arg Glu Pro Met Pro Gly Val Arg Gly
 625                 630                 635                 640
 Leu Ser Leu Asp Gly Leu Asp Leu Lys Leu Ser Ser Ala Pro Trp Pro
                 645                 650                 655    
 Cys Gly Lys Ser Pro Leu Val Glu Asn Gly Ala Leu Ser Met Gly Val
             660                 665                 670        
 Phe Lys Ala Gly Pro Met Ala Ala Ser Leu Gly Met Ser Arg Tyr Leu
         675                 680                 685            
 Asp Ile Cys Trp Lys Pro Gln Glu Ala Thr Glu Ala Gly Gln Gly Arg
     690                 695                 700                
 Ser Ser Arg Cys Pro Gln Gly Leu Ser Ser Gly Glu Gly Gln Ala Leu
 705                 710                 715                 720
 Ala Gln Leu Ala Thr Asp Ala Arg Gln Gln Asn Gly His Glu Cys Gln
                 725                 730                 735    
 Gly Ser Gln Lys Ala Ser Leu Trp Gly Ala Leu Glu Asn Ser Arg Glu
             740                 745                 750        
 Asp Arg Val Leu Tyr Arg Ser Arg His Lys Gly Asp Ile Cys Pro Val
         755                 760                 765            
 Ser Tyr Ser Ser Cys Pro Gly Ile Lys Thr Ser Asp His Arg Pro Val
     770                 775                 780                
 Tyr Gly Leu Phe Arg Val Lys His Ser Val Gly Ser Trp Gln Ile
 785                 790                 795                



      <210> 1758
      <211> 372
      <212> PRT
      <213> Homo sapiens


      <400> 1758
 Met Glu Leu Thr Trp Trp Ala Val Leu Thr Tyr Met Gly Val Cys Gly
   1               5                  10                  15    
 Ala Ala Leu Met Gly Leu Phe Leu Val Asn Arg Ala Asp Gly Asn Ala
              20                  25                  30        
 Gly Leu Met Leu Arg Arg Glu Val Glu Gly Arg Glu Trp Thr Val Glu
          35                  40                  45            
 Ser His His His Gly Arg Val Ile Glu Ala Lys Gly Asp Leu Val Ser
      50                  55                  60                
 His Phe Pro Ser Leu Gly Pro Ser Phe Phe Ile Cys Lys Met Gly Lys
  65                  70                  75                  80
 Leu Gly Tyr Phe Leu Phe Tyr Asp Ser Ile Phe Asn Phe Thr Cys Leu
                  85                  90                  95    
 Lys Asn Gly Ser Leu Lys Gln Met Asn Ala Tyr Thr Ser Leu Ile Ser
             100                 105                 110        
 Thr Gly Thr Met Gly Pro Pro Thr Val Thr Ile Leu Leu Arg Arg His
         115                 120                 125            
 Gln Arg Ser Lys Val Ile Arg Pro Ala Gln Gly Cys Met Ala Leu Tyr
     130                 135                 140                
 Leu His Pro Glu Thr His Pro Ser Glu Ala Arg Val Arg Arg Arg Asp
 145                 150                 155                 160
 Glu Glu Leu Gly Cys Leu Leu Val His Leu Arg Phe Leu Gln His Leu
                 165                 170                 175    
 Ile Ser Ser Ala Arg Lys Arg Ala Ser Arg Leu Trp Ser Asp Ile Phe
             180                 185                 190        
 Ser Glu Glu Ile Arg Phe Tyr Glu Leu Gly Glu Glu Ala Met Glu Met
         195                 200                 205            
 Phe Arg Gln Asp Glu Gly Tyr Ile Lys Glu Glu Glu Arg Pro Leu Pro
     210                 215                 220                
 Glu Asn Glu Phe Gln Arg Gln Val Trp Leu Leu Phe Glu Tyr Pro Glu
 225                 230                 235                 240
 Ser Ser Gly Pro Ala Arg Ile Ile Ala Ile Val Ser Val Met Val Ile
                 245                 250                 255    
 Leu Ile Ser Ile Val Ser Phe Cys Leu Glu Thr Leu Pro Ile Phe Arg
             260                 265                 270        
 Asp Glu Asn Glu Asp Met His Ala Ser Gly Val Thr Phe His Thr Tyr
         275                 280                 285            
 Ser Asn Ser Thr Ile Gly Tyr Gln Gln Ser Thr Ser Phe Thr Asp Pro
     290                 295                 300                
 Phe Phe Ile Val Glu Thr Leu Cys Ile Ile Trp Phe Ser Phe Glu Ser
 305                 310                 315                 320
 Leu Gly Glu Val Leu Cys Leu Ser Gln Arg Lys Pro Ala Ser Ser Pro
                 325                 330                 335    
 Thr Tyr Met Asn Ile Ile Asp Met Gly Ala Ile Ile Pro His Pro Ser
             340                 345                 350        
 Thr Pro Gly Thr Gln Arg Ala Glu Lys Pro Gln His Ala Gln Lys Pro
         355                 360                 365            
 Gln Gln Ala Ile
     370        



      <210> 1759
      <211> 534
      <212> PRT
      <213> Homo sapiens


      <400> 1759
 Met Val Thr Arg Ala Gly Ala Gly Thr Ala Val Ala Gly Ala Val Val
   1               5                  10                  15    
 Val Ala Leu Leu Ser Ala Ala Leu Ala Leu Tyr Gly Pro Pro Leu Asp
              20                  25                  30        
 Ala Val Leu Glu Arg Ala Phe Ser Leu Arg Lys Ala His Ser Ile Lys
          35                  40                  45            
 Asp Met Glu Asn Thr Leu Gln Leu Gly Ala Asp Leu Ser His Val Phe
      50                  55                  60                
 Cys Ala Ser Ala Ala Ala Pro Val Ile Lys Ala Tyr Ser Pro Glu Leu
  65                  70                  75                  80
 Ile Val His Pro Val Leu Asp Ser Pro Asn Ala Val His Glu Val Glu
                  85                  90                  95    
 Lys Trp Leu Pro Arg Leu His Ala Leu Val Val Gly Pro Gly Leu Gly
             100                 105                 110        
 Arg Asp Asp Ala Leu Leu Arg Asn Val Gln Pro Trp Arg His Ala Leu
         115                 120                 125            
 Leu Thr Ser Gly Ser Gln Thr Leu Asp Leu Ala Phe Trp Phe Leu Tyr
     130                 135                 140                
 Thr Val Ala Val Val Leu Arg Ala Leu Arg Ser Ser Ser Val Gly Cys
 145                 150                 155                 160
 Arg Leu Leu Val Ser Phe Gln Leu Val Ser Gly Ala Glu Gln Arg Leu
                 165                 170                 175    
 Pro Thr Ser Ser Thr Phe Leu Asn Glu Val Ile Ile Trp Cys Arg Pro
             180                 185                 190        
 Glu Asn Asn Pro Ile Ser Met Tyr Phe Tyr Val Gln Asn Trp Trp Val
         195                 200                 205            
 Leu Gly Leu Thr Asp Phe Lys Asn Glu Ala Val Asp Pro Arg Gly Val
     210                 215                 220                
 Arg Leu Gln Thr Phe Ala Val Ser Val Thr Ala Leu Lys Ala Ala Arg
 225                 230                 235                 240
 Leu Glu Leu Phe Val Pro Pro Gly Gly Leu Val Val Ser Leu Ala Ser
                 245                 250                 255    
 Gly Val Lys Leu Gln Ile Phe Ala Val Thr Val Thr Ala His Lys Ser
             260                 265                 270        
 Ser Val Asp Pro Lys Asn Ser Gly Ala Gln Leu Ala Ser Pro Ser Gly
         275                 280                 285            
 Ser Arg Thr Arg Ala Ala Gly Gly Ala Ala Cys Gln Ser Cys Ala Val
     290                 295                 300                
 Arg Ser His Ser Ser Ala Leu Gly Trp Ser Met Gly Leu Gly Ala Val
 305                 310                 315                 320
 Glu Gln Gly Val Val Leu Val Gly Glu Ala Arg Ala Ala Gln Glu Pro
                 325                 330                 335    
 Met Glu Gly Gly Ile Leu Glu Val Ser Lys Ala Arg Asp Ile Pro Val
             340                 345                 350        
 Val Ile Asp Ala Asp Gly Leu Trp Leu Val Ala Gln Gln Pro Ala Leu
         355                 360                 365            
 Ile His Gly Tyr Arg Lys Ala Val Leu Thr Pro Asn His Val Glu Phe
     370                 375                 380                
 Ser Arg Leu Tyr Asp Ala Val Leu Arg Gly Pro Met Asp Ser Asp Asp
 385                 390                 395                 400
 Ser His Gly Ser Val Leu Arg Leu Ser Gln Ala Leu Gly Asn Val Thr
                 405                 410                 415    
 Val Val Gln Lys Gly Glu Arg Asp Ile Leu Ser Asn Gly Gln Gln Gly
             420                 425                 430        
 Glu Trp Arg Leu Pro Ser Val His Gly Pro Val Pro Val Leu Val Cys
         435                 440                 445            
 Ser Gln Glu Gly Ser Ser Arg Arg Cys Gly Gly Gln Gly Asp Leu Leu
     450                 455                 460                
 Ser Gly Ser Leu Gly Val Leu Val His Trp Ala Leu Leu Ala Gly Pro
 465                 470                 475                 480
 Gln Lys Thr Asn Gly Ser Ser Pro Leu Leu Val Ala Ala Phe Gly Ala
                 485                 490                 495    
 Cys Ser Leu Thr Arg Gln Cys Asn His Gln Ala Phe Gln Lys His Gly
             500                 505                 510        
 Arg Ser Thr Thr Thr Ser Asp Met Ile Ala Glu Val Gly Ala Ala Phe
         515                 520                 525            
 Ser Lys Leu Phe Glu Thr
     530                



      <210> 1760
      <211> 224
      <212> PRT
      <213> Homo sapiens


      <400> 1760
 Met Asn Glu Ile Val Arg Thr Lys Glu Phe Glu Gly Asn Met Thr Trp
   1               5                  10                  15    
 Lys Ile Lys Leu Lys Ser Ala Met Tyr Phe Ser Asn Met Thr Val Thr
              20                  25                  30        
 Met Val Ala Asn Leu Val Pro Phe Thr Leu Thr Leu Leu Ser Phe Met
          35                  40                  45            
 Leu Leu Ile Cys Ser Leu Cys Lys His Leu Lys Lys Met Gln Leu His
      50                  55                  60                
 Gly Lys Gly Ser Gln Asp Pro Ser Thr Lys Val His Ile Lys Ala Leu
  65                  70                  75                  80
 Gln Thr Val Ile Ser Phe Leu Leu Leu Cys Ala Ile Tyr Phe Leu Ser
                  85                  90                  95    
 Ile Met Ile Ser Val Trp Ser Phe Gly Ser Leu Glu Asn Lys Pro Val
             100                 105                 110        
 Phe Met Phe Cys Lys Ala Ile Arg Phe Ser Tyr Pro Ser Ile His Pro
         115                 120                 125            
 Phe Ile Leu Ile Trp Gly Asn Lys Lys Leu Lys Gln Thr Phe Leu Ser
     130                 135                 140                
 Val Phe Trp Gln Met Arg Tyr Trp Gly Phe Leu Glu Ala Glu Leu Ser
 145                 150                 155                 160
 Ser Leu Leu Phe Cys Leu Pro Ser Ser Ser Pro Leu Val Val Val Met
                 165                 170                 175    
 Lys Val Ile Pro Tyr Ala His Ser Val Val Met His Ser Ser Pro Lys
             180                 185                 190        
 Trp Asn Asp Asp Leu Asp Arg Ala Ser Ile Phe Glu Ser Cys Trp Ile
         195                 200                 205            
 Ile Trp His Ser Gly Gln Ser Ser Leu Glu Gln Ser Pro Tyr Leu Leu
     210                 215                 220                





      <210> 1761
      <211> 278
      <212> PRT
      <213> Homo sapiens


      <400> 1761
 Met Ala Phe Ser Leu Ser Ser Leu Gln Cys Leu Ala Phe Cys Ile Leu
   1               5                  10                  15    
 Ile Phe Tyr Ser Leu Glu Pro Leu Gly Gln Leu Glu Gly Ser Pro Ala
              20                  25                  30        
 Ala Ser Cys Lys Ala Lys Glu Val Thr Gly Asp Ala Ala Arg Thr His
          35                  40                  45            
 Thr Asp Phe Lys His Ser Glu Cys Gly Gln Thr Leu Lys Pro Asp Lys
      50                  55                  60                
 Val Met Trp Lys Arg Gln Thr Arg Asn Arg Ser Leu Arg Arg Asp Glu
  65                  70                  75                  80
 Gly Gln Lys Gly Ser Ser Arg Glu Glu Lys Val Glu Ala Asp Met Leu
                  85                  90                  95    
 Lys Lys Leu Ser Gln Thr Met Arg Ile Thr Asn Thr Gln Cys Gln Tyr
             100                 105                 110        
 Ser Thr Lys Asn Val His Gly His Leu Thr Thr Thr Ser Ala Arg Val
         115                 120                 125            
 Thr Ser Gln Ala Ile Cys Ser Ser Gly Gln His Ser Pro Cys Trp Pro
     130                 135                 140                
 Asp Asn Asp Ala Leu Asn Cys Ala Met Asp Phe Arg Thr Arg Val Trp
 145                 150                 155                 160
 Lys Cys Thr Arg Leu Ala Ser Asn Asp Ala Met Ser Leu Thr Ser Ser
                 165                 170                 175    
 Ser Ser Ile Arg Val Glu Trp Ile Thr Ala Phe Thr Ile Ala Ala Gly
             180                 185                 190        
 Arg Ala Ala Thr Gly Tyr Leu Ala Tyr Lys Arg Phe Tyr Asp Lys Asp
         195                 200                 205            
 His Gln Asn Lys Ala Met Met Asn Leu His Ile Gln Lys Asp Asn Pro
     210                 215                 220                
 Lys Ile Val His Ala Phe Asp Met Glu Asp Leu Glu Asp Lys Ala Val
 225                 230                 235                 240
 Tyr Cys His Cys Trp Arg Tyr Lys Lys Phe Pro Phe Cys Asp Gly Ser
                 245                 250                 255    
 His Thr Lys His Asn Glu Gln Thr Gly Asp Asn Val Gly Pro Leu Ile
             260                 265                 270        
 Ile Glu Lys Lys Glu Thr
         275            



      <210> 1762
      <211> 779
      <212> PRT
      <213> Homo sapiens


      <400> 1762
 Met Arg Ala Val Leu Asp Thr Ala Asp Ile Ala Ile Val Ala Leu Tyr
   1               5                  10                  15    
 Phe Ile Leu Val Met Cys Ile Gly Phe Phe Ala Met Trp Lys Ser Asn
              20                  25                  30        
 Arg Ser Thr Val Ser Gly Tyr Phe Leu Ala Gly Arg Ser Met Thr Trp
          35                  40                  45            
 Val Thr Ile Gly Ala Ser Leu Phe Val Ser Asn Ile Gly Ser Glu His
      50                  55                  60                
 Phe Ile Gly Leu Ala Gly Ser Gly Ala Ala Ser Gly Phe Ala Val Gly
  65                  70                  75                  80
 Ala Trp Glu Phe Asn Ala Leu Leu Leu Leu Gln Leu Leu Gly Trp Val
                  85                  90                  95    
 Phe Ile Pro Ile Tyr Ile Arg Ser Gly Val Tyr Thr Met Pro Glu Tyr
             100                 105                 110        
 Leu Ser Lys Arg Phe Gly Gly His Arg Ile Gln Val Tyr Phe Ala Ala
         115                 120                 125            
 Leu Ser Leu Ile Leu Tyr Ile Phe Thr Lys Leu Ser Val Asp Leu Tyr
     130                 135                 140                
 Ser Gly Ala Leu Phe Ile Gln Glu Ser Leu Gly Trp Asn Leu Tyr Val
 145                 150                 155                 160
 Ser Val Ile Leu Leu Ile Gly Met Thr Ala Leu Leu Thr Val Thr Gly
                 165                 170                 175    
 Gly Leu Val Ala Val Ile Tyr Thr Asp Thr Leu Gln Ala Leu Leu Met
             180                 185                 190        
 Ile Ile Gly Ala Leu Thr Leu Met Ile Ile Ser Ile Met Glu Ile Gly
         195                 200                 205            
 Gly Phe Glu Glu Val Lys Arg Arg Tyr Met Leu Ala Ser Pro Asp Val
     210                 215                 220                
 Thr Ser Ile Leu Leu Thr Tyr Asn Leu Ser Asn Thr Asn Ser Cys Asn
 225                 230                 235                 240
 Val Ser Pro Lys Lys Glu Ala Leu Lys Met Leu Arg Asn Pro Thr Asp
                 245                 250                 255    
 Glu Asp Val Pro Trp Pro Gly Phe Ile Leu Gly Gln Thr Pro Ala Ser
             260                 265                 270        
 Val Trp Tyr Trp Cys Ala Asp Gln Val Ile Val Gln Arg Val Leu Ala
         275                 280                 285            
 Ala Lys Asn Ile Ala His Ala Lys Gly Ser Thr Leu Met Ala Gly Phe
     290                 295                 300                
 Leu Lys Leu Leu Pro Met Phe Ile Ile Val Val Pro Gly Met Ile Ser
 305                 310                 315                 320
 Arg Ile Leu Phe Thr Asp Asp Ile Ala Cys Ile Asn Pro Glu His Cys
                 325                 330                 335    
 Met Leu Val Cys Gly Ser Arg Ala Gly Cys Ser Asn Ile Ala Tyr Pro
             340                 345                 350        
 Arg Leu Val Met Lys Leu Val Pro Val Gly Leu Arg Gly Leu Met Met
         355                 360                 365            
 Ala Val Met Ile Ala Ala Leu Met Ser Asp Leu Asp Ser Ile Phe Asn
     370                 375                 380                
 Ser Ala Ser Thr Ile Phe Thr Leu Asp Val Tyr Lys Leu Ile Arg Lys
 385                 390                 395                 400
 Ser Ala Ser Ser Arg Glu Leu Met Ile Val Gly Arg Ile Phe Val Ala
                 405                 410                 415    
 Phe Met Val Val Ile Ser Ile Ala Trp Val Pro Ile Ile Val Glu Met
             420                 425                 430        
 Gln Gly Gly Gln Met Tyr Leu Tyr Ile Gln Glu Val Ala Asp Tyr Leu
         435                 440                 445            
 Thr Pro Pro Val Ala Ala Leu Phe Leu Leu Ala Ile Phe Trp Lys Arg
     450                 455                 460                
 Cys Asn Glu Gln Gly Ala Phe Tyr Gly Gly Met Ala Gly Phe Val Leu
 465                 470                 475                 480
 Gly Ala Val Arg Leu Ile Leu Ala Phe Ala Tyr Arg Ala Pro Glu Cys
                 485                 490                 495    
 Asp Gln Pro Asp Asn Arg Pro Gly Phe Ile Lys Asp Ile His Tyr Met
             500                 505                 510        
 Tyr Val Ala Thr Gly Leu Phe Trp Val Thr Gly Leu Ile Thr Val Ile
         515                 520                 525            
 Val Ser Leu Leu Thr Pro Pro Pro Thr Lys Glu Gln Ile Arg Thr Thr
     530                 535                 540                
 Thr Phe Trp Ser Lys Lys Asn Leu Val Val Lys Glu Asn Cys Ser Pro
 545                 550                 555                 560
 Lys Glu Glu Pro Tyr Gln Met Gln Glu Lys Ser Ile Leu Arg Cys Ser
                 565                 570                 575    
 Glu Asn Asn Glu Thr Ile Asn His Ile Ile Pro Asn Gly Lys Ser Glu
             580                 585                 590        
 Asp Ser Ile Lys Gly Leu Gln Pro Glu Asp Val Asn Leu Leu Val Thr
         595                 600                 605            
 Cys Arg Glu Glu Gly Asn Pro Val Ala Ser Leu Gly His Ser Glu Ala
     610                 615                 620                
 Glu Thr Pro Val Asp Ala Tyr Ser Asn Gly Gln Ala Ala Leu Met Gly
 625                 630                 635                 640
 Glu Lys Glu Arg Lys Lys Glu Thr Asp Asp Gly Gly Arg Tyr Trp Lys
                 645                 650                 655    
 Phe Ile Asp Trp Phe Cys Gly Phe Lys Ser Lys Ser Leu Ser Lys Arg
             660                 665                 670        
 Ser Leu Arg Asp Leu Met Glu Glu Glu Ala Val Cys Leu Gln Met Leu
         675                 680                 685            
 Glu Glu Thr Arg Gln Val Lys Val Ile Leu Asn Ile Gly Leu Phe Ala
     690                 695                 700                
 Asn Val Ile Ala Asn Val Ser Ser Arg Ile Leu Pro Phe Asp Ser Asn
 705                 710                 715                 720
 Ala Gly Ile Asp Gly Leu Ala Gly Thr Trp Cys Arg Gly Pro Leu Asp
                 725                 730                 735    
 Gly Leu Gln Arg Ala Val Cys Ala Gly Asp Tyr Glu Met Cys Ile Ser
             740                 745                 750        
 His Pro Pro Ala Leu Ser Leu Arg Phe Thr Ser Gly Glu Val Asn Leu
         755                 760                 765            
 Gly Glu Pro Trp His Leu Arg Leu Ser Val Ser
     770                 775                



      <210> 1763
      <211> 593
      <212> PRT
      <213> Homo sapiens


      <400> 1763
 Met Asp Ala Ala Thr Ala Pro Lys Gln Ala Trp Pro Pro Trp Pro Pro
   1               5                  10                  15    
 Leu Leu Phe Leu Leu Leu Leu Pro Gly Gly Ser Gly Gly Ser Cys Pro
              20                  25                  30        
 Ala Val Cys Asp Cys Thr Ser Gln Pro Gln Ala Val Leu Cys Gly His
          35                  40                  45            
 Arg Gln Leu Glu Ala Val Pro Gly Gly Leu Pro Leu Asp Thr Glu Leu
      50                  55                  60                
 Leu Asp Leu Ser Gly Asn Arg Leu Trp Gly Leu Gln Gln Gly Met Leu
  65                  70                  75                  80
 Ser Arg Leu Ser Leu Leu Gln Glu Leu Asp Leu Ser Tyr Asn Gln Leu
                  85                  90                  95    
 Ser Thr Leu Glu Pro Gly Ala Phe His Gly Leu Gln Ser Leu Leu Thr
             100                 105                 110        
 Leu Arg Leu Gln Gly Asn Arg Leu Arg Ile Met Gly Pro Gly Val Phe
         115                 120                 125            
 Ser Gly Leu Ser Ala Leu Thr Leu Leu Asp Leu Arg Leu Asn Gln Ile
     130                 135                 140                
 Val Leu Phe Leu Asp Gly Ala Phe Gly Glu Leu Gly Ser Leu Gln Lys
 145                 150                 155                 160
 Leu Glu Val Gly Asp Asn His Leu Val Phe Val Ala Pro Gly Ala Phe
                 165                 170                 175    
 Ala Gly Leu Ala Lys Leu Ser Thr Leu Thr Leu Glu Arg Cys Asn Leu
             180                 185                 190        
 Ser Thr Val Pro Gly Leu Ala Leu Ala Arg Leu Pro Ala Leu Val Ala
         195                 200                 205            
 Leu Arg Leu Arg Glu Leu Asp Ile Gly Arg Leu Pro Ala Gly Ala Leu
     210                 215                 220                
 Arg Gly Leu Gly Gln Leu Lys Glu Leu Glu Ile His Leu Trp Pro Ser
 225                 230                 235                 240
 Leu Glu Ala Leu Asp Pro Gly Ser Leu Val Gly Leu Asn Leu Ser Ser
                 245                 250                 255    
 Leu Ala Ile Thr Arg Cys Asn Leu Ser Ser Val Pro Phe Gln Ala Leu
             260                 265                 270        
 Tyr His Leu Ser Phe Leu Arg Val Leu Asp Leu Ser Gln Asn Pro Ile
         275                 280                 285            
 Ser Ala Ile Pro Ala Arg Arg Leu Ser Pro Leu Val Arg Leu Gln Glu
     290                 295                 300                
 Leu Arg Leu Ser Gly Ala Cys Leu Thr Ser Ile Ala Ala His Ala Phe
 305                 310                 315                 320
 His Gly Leu Thr Ala Phe His Leu Leu Asp Val Ala Asp Asn Ala Leu
                 325                 330                 335    
 Gln Thr Leu Glu Glu Thr Ala Phe Pro Ser Pro Asp Lys Leu Val Thr
             340                 345                 350        
 Leu Arg Leu Ser Gly Asn Pro Leu Thr Cys Asp Cys Arg Leu Leu Trp
         355                 360                 365            
 Leu Leu Arg Leu Arg Arg His Leu Asp Phe Gly Met Ser Pro Pro Ala
     370                 375                 380                
 Cys Ala Gly Pro His His Val Gln Gly Lys Ser Leu Lys Glu Phe Ser
 385                 390                 395                 400
 Asp Ile Leu Pro Pro Gly His Phe Thr Cys Lys Pro Ala Leu Ile Arg
                 405                 410                 415    
 Lys Ser Gly Pro Arg Trp Val Ile Ala Glu Glu Gly Gly His Ala Val
             420                 425                 430        
 Phe Ser Cys Ser Gly Asp Gly Asp Pro Ala Pro Thr Val Ser Trp Met
         435                 440                 445            
 Arg Pro His Gly Ala Trp Leu Gly Arg Ala Gly Arg Val Arg Val Leu
     450                 455                 460                
 Glu Asp Gly Thr Leu Glu Ile Arg Ser Val Gln Leu Arg Asp Arg Gly
 465                 470                 475                 480
 Ala Tyr Val Cys Val Val Ser Asn Val Ala Gly Asn Asp Ser Leu Arg
                 485                 490                 495    
 Thr Trp Leu Glu Val Ile Gln Val Glu Pro Pro Asn Gly Thr Leu Ser
             500                 505                 510        
 Asp Pro Asn Ile Thr Val Pro Gly Ile Pro Gly Pro Phe Phe Leu Asp
         515                 520                 525            
 Ser Arg Gly Val Ala Met Val Leu Ala Val Gly Phe Leu Pro Phe Leu
     530                 535                 540                
 Thr Ser Val Thr Leu Cys Phe Gly Leu Ile Ala Leu Trp Ser Lys Gly
 545                 550                 555                 560
 Lys Gly Arg Val Lys His His Met Thr Phe Asp Phe Val Ala Pro Arg
                 565                 570                 575    
 Pro Ser Gly Asp Lys Asn Ser Gly Gly Asn Arg Val Thr Ala Lys Leu
             580                 585                 590        
 Phe
    



      <210> 1764
      <211> 710
      <212> PRT
      <213> Homo sapiens


      <400> 1764
 Met Leu Ala Phe Leu Leu Thr Ile Leu Ala Ser Ile Phe Ser Phe Val
   1               5                  10                  15    
 Asn Gly Gly Gly Asp Asn Ser Asn Leu Ser Ser Gln Leu Leu Ala Gln
              20                  25                  30        
 Glu His Asn Tyr Ser Ser Pro Ala Gly His His Pro His Val Leu Tyr
          35                  40                  45            
 Lys Arg Thr Ala Glu Glu Lys Ile Gln Arg Tyr Arg Gly Tyr Pro Gly
      50                  55                  60                
 Ser Gly Arg Asn Tyr Pro Gly Tyr Ser Pro Ser His Ile Pro His Ala
  65                  70                  75                  80
 Ser Gln Ser Arg Glu Thr Glu Tyr His His Arg Arg Leu Gln Lys Gln
                  85                  90                  95    
 His Phe Cys Gly Arg Arg Lys Lys Cys Ile Tyr Ser Leu Ile Ser Leu
             100                 105                 110        
 Pro Asn Ala Leu Leu Phe Ile Val Asp Ala Pro Lys Pro Pro Thr Glu
         115                 120                 125            
 Asp Thr Tyr Leu Arg Phe Asp Glu Tyr Gly Ser Ser Gly Arg Pro Arg
     130                 135                 140                
 Arg Ser Ala Gly Lys Ser Gln Lys Gly Leu Asn Val Glu Thr Leu Val
 145                 150                 155                 160
 Val Ala Asp Lys Lys Met Val Glu Lys His Gly Lys Gly Asn Val Thr
                 165                 170                 175    
 Thr Tyr Ile Leu Thr Val Met Asn Met Val Ser Gly Leu Phe Lys Asp
             180                 185                 190        
 Gly Thr Ile Gly Ser Asp Ile Asn Val Val Val Val Ser Leu Ile Leu
         195                 200                 205            
 Leu Glu Gln Glu Pro Gly Gly Leu Leu Ile Asn His His Ala Asp Gln
     210                 215                 220                
 Ser Leu Asn Ser Phe Cys Gln Trp Gln Ser Ala Leu Ile Gly Lys Asn
 225                 230                 235                 240
 Gly Lys Arg His Asp His Ala Ile Leu Leu Thr Gly Phe Asp Ile Cys
                 245                 250                 255    
 Ser Trp Lys Asn Glu Pro Cys Asp Thr Leu Gly Phe Ala Pro Ile Ser
             260                 265                 270        
 Gly Met Cys Ser Lys Tyr Arg Ser Cys Thr Ile Asn Glu Asp Thr Gly
         275                 280                 285            
 Leu Gly Leu Ala Phe Thr Ile Ala His Glu Ser Gly His Asn Phe Gly
     290                 295                 300                
 Met Ile His Asp Gly Glu Gly Asn Pro Cys Arg Lys Ala Glu Gly Asn
 305                 310                 315                 320
 Ile Met Ser Pro Thr Leu Thr Gly Asn Asn Gly Val Phe Ser Trp Ser
                 325                 330                 335    
 Ser Cys Ser Arg Gln Tyr Leu Lys Lys Phe Leu Ser Thr Pro Gln Ala
             340                 345                 350        
 Gly Cys Leu Val Asp Glu Pro Lys Gln Ala Gly Gln Tyr Lys Tyr Pro
         355                 360                 365            
 Asp Lys Leu Pro Gly Gln Ile Tyr Asp Ala Asp Thr Gln Cys Lys Trp
     370                 375                 380                
 Gln Phe Gly Ala Lys Ala Lys Leu Cys Ser Leu Gly Phe Val Lys Trp
 385                 390                 395                 400
 Cys Arg Gln Gly Gln Cys Val Lys Phe Gly Glu Leu Gly Pro Arg Pro
                 405                 410                 415    
 Ile His Gly Gln Trp Ser Ala Trp Ser Lys Trp Ser Glu Cys Ser Arg
             420                 425                 430        
 Thr Cys Gly Gly Gly Val Lys Phe Gln Glu Arg His Cys Asn Asn Pro
         435                 440                 445            
 Lys Asp Leu Pro Asn Val Leu Leu Gln Ala Phe Val Leu Asn Arg Val
     450                 455                 460                
 Arg Thr Asp Thr Pro Gln Tyr Gly Gly Leu Phe Cys Pro Gly Ser Ser
 465                 470                 475                 480
 Arg Ile Tyr Gln Leu Cys Asn Ile Asn Pro Cys Asn Glu Asn Ser Leu
                 485                 490                 495    
 Asp Phe Arg Ala Gln Gln Cys Ala Glu Tyr Asn Ser Lys Pro Phe Arg
             500                 505                 510        
 Gly Trp Phe Tyr Gln Trp Lys Pro Tyr Thr Lys Val Glu Glu Glu Asp
         515                 520                 525            
 Arg Cys Lys Leu Tyr Cys Lys Ala Glu Asn Phe Glu Phe Phe Phe Ala
     530                 535                 540                
 Met Ser Gly Lys Val Lys Asp Gly Thr Pro Cys Ser Pro Asn Lys Asn
 545                 550                 555                 560
 Asp Val Cys Ile Asp Gly Val Cys Glu Leu Val Gly Cys Asp His Glu
                 565                 570                 575    
 Leu Gly Ser Lys Ala Val Ser Asp Ala Cys Gly Val Cys Lys Gly Asp
             580                 585                 590        
 Asn Ser Thr Cys Lys Phe Tyr Lys Gly Leu Tyr Leu Asn Gln His Lys
         595                 600                 605            
 Ala Asn Glu Tyr Tyr Pro Val Val Leu Ile Pro Ala Gly Ala Arg Ser
     610                 615                 620                
 Ile Glu Ile Gln Glu Leu Gln Val Ser Ser Ser Tyr Leu Ala Val Arg
 625                 630                 635                 640
 Ser Leu Ser Gln Lys Tyr Tyr Leu Thr Gly Gly Trp Ser Ile Asp Trp
                 645                 650                 655    
 Pro Gly Glu Phe Pro Phe Ala Gly Thr Thr Phe Glu Tyr Gln Arg Ser
             660                 665                 670        
 Phe Asn Arg Pro Glu Arg Leu Tyr Ala Pro Gly Pro Thr Asn Glu Thr
         675                 680                 685            
 Leu Val Phe Glu Val Ser Pro Phe Cys Val Phe Ser Ser Gln Cys Phe
     690                 695                 700                
 Leu Leu His Leu Tyr Arg
 705                 710



      <210> 1765
      <211> 148
      <212> PRT
      <213> Homo sapiens


      <400> 1765
 Met Asp Thr Ser Pro Leu Cys Phe Ser Ile Leu Leu Val Leu Cys Ile
   1               5                  10                  15    
 Phe Ile Gln Ser Ser Ala Leu Gly Gln Ser Leu Lys Pro Asp Gly Tyr
              20                  25                  30        
 Ser Asp Ala Ser Leu Arg Ala Pro His Ala Gln Leu Leu His Ala Ser
          35                  40                  45            
 Ala Thr Met Gln Pro Ile Trp Ile Met Asp Cys Tyr Glu Ala Cys Thr
      50                  55                  60                
 Leu Ile Pro His Ser Arg Ser Asn Leu Leu Met Glu Val Leu Glu Cys
  65                  70                  75                  80
 Val Phe Ser Leu Ile Leu Ser Pro Thr His His Thr Ala Cys Thr Gly
                  85                  90                  95    
 Ser Ser Lys Leu His Ala Lys Cys Leu Tyr Pro Ser Val Ser Lys Lys
             100                 105                 110        
 Glu Arg Lys Glu Ser Ile Arg Ser Phe Leu Cys Pro Glu Ile Ala Gln
         115                 120                 125            
 Val Phe Thr Arg Ser Thr Pro Ile Ser Leu Thr Ser Phe Leu Pro Cys
     130                 135                 140                
 Phe Ser Ala Thr
 145            



      <210> 1766
      <211> 363
      <212> PRT
      <213> Homo sapiens


      <400> 1766
 Met Gly Leu Leu Leu Met Ile Leu Ala Ser Ala Val Leu Gly Ser Phe
   1               5                  10                  15    
 Leu Thr Leu Leu Ala Gln Phe Phe Leu Leu Tyr Arg Arg Gln Pro Glu
              20                  25                  30        
 Pro Pro Ala Asp Glu Ala Ala Arg Ala Gly Glu Gly Phe Arg Tyr Ile
          35                  40                  45            
 Lys Pro Val Pro Gly Leu Leu Leu Arg Glu Tyr Leu Tyr Gly Gly Gly
      50                  55                  60                
 Arg Asp Glu Glu Pro Ser Gly Ala Ala Pro Glu Gly Gly Ala Thr Pro
  65                  70                  75                  80
 Thr Ala Ala Pro Glu Thr Pro Ala Pro Pro Thr Arg Glu Thr Cys Tyr
                  85                  90                  95    
 Phe Leu Asn Ala Thr Ile Leu Phe Leu Phe Arg Glu Leu Arg Asp Thr
             100                 105                 110        
 Ala Leu Thr Arg Arg Trp Val Thr Lys Lys Ile Lys Val Glu Phe Glu
         115                 120                 125            
 Glu Leu Leu Gln Thr Lys Thr Ala Gly Arg Leu Leu Glu Gly Leu Ser
     130                 135                 140                
 Leu Arg Asp Val Phe Leu Gly Glu Thr Val Pro Phe Ile Lys Thr Ile
 145                 150                 155                 160
 Arg Leu Val Arg Pro Val Val Pro Ser Ala Thr Gly Glu Pro Asp Gly
                 165                 170                 175    
 Pro Glu Gly Glu Ala Leu Pro Ala Ala Cys Pro Glu Glu Leu Ala Phe
             180                 185                 190        
 Glu Ala Glu Val Glu Tyr Asn Gly Gly Phe His Leu Ala Ile Asp Val
         195                 200                 205            
 Asp Leu Val Phe Gly Lys Ser Ala Tyr Leu Phe Val Lys Leu Ser Arg
     210                 215                 220                
 Val Val Gly Arg Leu Arg Leu Val Phe Thr Arg Val Pro Phe Thr His
 225                 230                 235                 240
 Trp Phe Phe Ser Phe Val Glu Asp Pro Leu Ile Asp Phe Glu Val Arg
                 245                 250                 255    
 Ser Gln Phe Glu Gly Arg Pro Met Pro Gln Leu Thr Ser Ile Ile Val
             260                 265                 270        
 Asn Gln Leu Lys Lys Ile Ile Lys Arg Lys His Thr Leu Pro Asn Tyr
         275                 280                 285            
 Lys Ile Ser Ile Pro Leu Ala Ala Leu Arg Asn Cys Ser Trp Thr Gln
     290                 295                 300                
 Tyr Thr Arg Glu Glu Cys Ala Tyr Ser Pro Glu Ala Ile Trp Arg Thr
 305                 310                 315                 320
 Gly Gly Gln Leu Gln Pro Pro Met Ser Ser Ser Leu Pro Gln Pro Ile
                 325                 330                 335    
 Ser Ser Lys Pro Leu Leu Ala Gly His Pro Thr Pro Phe Pro Lys Leu
             340                 345                 350        
 Pro Leu Lys Asn Pro Ser Pro Thr Ser Phe Glu
         355                 360            



      <210> 1767
      <211> 165
      <212> PRT
      <213> Homo sapiens


      <400> 1767
 Met Asp Leu Ala Gly Leu Leu Lys Ser Gln Phe Leu Cys His Leu Val
   1               5                  10                  15    
 Phe Cys Tyr Val Phe Ile Ala Ser Gly Leu Ile Ile Asn Thr Ile Gln
              20                  25                  30        
 Leu Phe Thr Leu Leu Leu Trp Pro Ile Asn Lys Gln Leu Phe Arg Lys
          35                  40                  45            
 Ile Asn Cys Arg Leu Ser Tyr Cys Ile Ser Ser Arg His Val Val Leu
      50                  55                  60                
 Leu Pro Glu Glu Gln Gly Thr Asn Ser Ser Asp Thr Asp Thr Ser His
  65                  70                  75                  80
 His Arg Ala Phe Pro Val Asn Ala Tyr Val Phe Asn Trp Ser Leu Gln
                  85                  90                  95    
 Ala Ser His Arg Thr Cys Ser Thr Leu Gln Val Thr Tyr Ser Ile Gln
             100                 105                 110        
 Tyr Ser His Met Leu Tyr Ser Phe Asp His Met Met Lys Phe Cys Asn
         115                 120                 125            
 Ile Cys Phe Tyr Thr Thr Gly Ile Met Gly Leu Leu Ser Glu Leu Leu
     130                 135                 140                
 His Glu Val Cys Ala Arg Lys Arg Phe Glu Leu Leu Lys Ile Ser Gly
 145                 150                 155                 160
 Tyr Cys Thr Asn Phe
                 165



      <210> 1768
      <211> 295
      <212> PRT
      <213> Homo sapiens


      <400> 1768
 Met Pro Gly Lys Arg Gly Leu Gly Trp Trp Trp Ala Arg Leu Pro Leu
   1               5                  10                  15    
 Cys Leu Leu Leu Ser Leu Tyr Gly Pro Trp Met Pro Ser Ser Leu Gly
              20                  25                  30        
 Lys Pro Lys Gly His Pro His Met Asn Ser Ile Arg Ile Asp Gly Asp
          35                  40                  45            
 Ile Thr Leu Gly Gly Leu Phe Pro Val His Gly Arg Gly Ser Glu Gly
      50                  55                  60                
 Lys Pro Cys Gly Glu Leu Lys Lys Glu Lys Gly Ile His Arg Leu Glu
  65                  70                  75                  80
 Ala Met Leu Phe Ala Leu Asp Arg Ile Asn Asn Asp Pro Asp Leu Leu
                  85                  90                  95    
 Pro Asn Ile Thr Leu Gly Ala Arg Ile Leu Asp Thr Cys Ser Arg Asp
             100                 105                 110        
 Thr His Ala Leu Glu Gln Ser Leu Thr Phe Val Gln Ala Leu Ile Glu
         115                 120                 125            
 Lys Asp Gly Thr Glu Val Arg Cys Gly Ser Gly Gly Pro Pro Ile Ile
     130                 135                 140                
 Thr Lys Pro Glu Arg Val Val Gly Val Ile Gly Ala Ser Gly Ser Ser
 145                 150                 155                 160
 Val Ser Ile Met Val Ala Asn Ile Leu Arg Leu Phe Lys Val Ser Ala
                 165                 170                 175    
 Leu Val Gly Pro Leu Arg Cys Ser Ser Pro Asn Gly Leu Cys Pro Pro
             180                 185                 190        
 His Phe Arg Val Pro Gly Leu Ala Asp Gln Pro Leu Phe Pro Pro Phe
         195                 200                 205            
 Phe Leu Thr Leu Arg Asp Ser Phe Phe Leu Arg Ala Val Ser Glu Asn
     210                 215                 220                
 Leu Gly Gln Leu Phe Leu Val Ser Val Cys Cys Leu Val Val Ser Ala
 225                 230                 235                 240
 Gln Ala Gln Gln Met Lys Gly Ile Gly Thr Gln Pro Cys Gly Ala Asp
                 245                 250                 255    
 Arg Gly Ala Glu Thr Ala Pro Ala Ala Gly Gly Ser Val Ser Asn Ser
             260                 265                 270        
 Thr Pro Leu Trp Gly Ile Leu Tyr Gln Glu Glu Lys Asp Val Leu Glu
         275                 280                 285            
 Asn Asp Arg Gly Arg Arg Arg
     290                 295



      <210> 1769
      <211> 505
      <212> PRT
      <213> Homo sapiens


      <400> 1769
 Met Ala Thr Ser Thr Pro Ser Arg Ile Gly Thr Phe Val Phe Trp Thr
   1               5                  10                  15    
 Leu Asp Phe Thr Pro Leu Thr Ser Ala Thr His Pro Ala Pro Thr Leu
              20                  25                  30        
 Arg Pro Asp Leu Leu Asn Leu Asp Ile Val Arg Pro Glu Leu Tyr Ser
          35                  40                  45            
 Cys Cys Leu Gly Thr Asp Arg Gly Phe Pro Glu Leu Ser His His Cys
      50                  55                  60                
 Lys Asn Val Ile Ala Thr Ala Ser Asp Tyr Asp Met Ala Glu Ile Thr
  65                  70                  75                  80
 Asn Ile Arg Pro Ser Phe Asp Val Ser Pro Val Val Ala Gly Leu Ile
                  85                  90                  95    
 Gly Ala Ser Val Leu Val Val Cys Val Ser Val Thr Val Phe Val Trp
             100                 105                 110        
 Ser Cys Cys His Gln Gln Ala Glu Lys Lys Gln Lys Asn Pro Pro Tyr
         115                 120                 125            
 Lys Phe Ile His Met Leu Lys Gly Ile Ser Ile Tyr Pro Glu Thr Leu
     130                 135                 140                
 Ser Asn Lys Lys Lys Ile Ile Lys Val Arg Arg Asp Lys Asp Gly Pro
 145                 150                 155                 160
 Gly Arg Glu Gly Gly Arg Arg Asn Leu Leu Val Asp Ala Ala Glu Ala
                 165                 170                 175    
 Gly Leu Leu Ser Arg Asp Lys Asp Pro Arg Gly Pro Ser Ser Gly Ser
             180                 185                 190        
 Cys Ile Asp Gln Leu Pro Ile Lys Met Asp Tyr Gly Glu Glu Leu Arg
         195                 200                 205            
 Ser Pro Ile Thr Ser Leu Thr Pro Gly Glu Ser Lys Thr Thr Ser Pro
     210                 215                 220                
 Ser Ser Pro Glu Glu Asp Val Met Leu Gly Ser Leu Thr Phe Ser Val
 225                 230                 235                 240
 Asp Tyr Asn Phe Pro Lys Lys Ala Leu Val Val Thr Ile Gln Glu Ala
                 245                 250                 255    
 His Gly Leu Pro Val Met Asp Asp Gln Thr Gln Gly Ser Asp Pro Tyr
             260                 265                 270        
 Ile Lys Met Thr Ile Leu Pro Asp Lys Arg His Arg Val Lys Thr Arg
         275                 280                 285            
 Val Leu Arg Lys Thr Leu Asp Pro Val Phe Asp Glu Thr Phe Thr Phe
     290                 295                 300                
 Tyr Gly Ile Pro Tyr Ser Gln Leu Gln Asp Leu Val Leu His Phe Leu
 305                 310                 315                 320
 Val Leu Ser Phe Asp Arg Phe Ser Arg Asp Asp Val Ile Gly Glu Val
                 325                 330                 335    
 Met Val Pro Leu Ala Gly Val Asp Pro Ser Thr Gly Lys Val Gln Leu
             340                 345                 350        
 Thr Arg Asp Ile Ile Lys Arg Asn Ile Gln Lys Cys Ile Ser Arg Gly
         355                 360                 365            
 Glu Leu Gln Val Ser Leu Ser Tyr Gln Pro Val Ala Gln Arg Met Thr
     370                 375                 380                
 Val Val Val Leu Lys Ala Arg His Leu Pro Lys Met Asp Ile Thr Gly
 385                 390                 395                 400
 Leu Ser Asp Pro Tyr Val Lys Val Asn Val Tyr Tyr Gly Arg Lys Arg
                 405                 410                 415    
 Ile Ala Lys Lys Lys Thr His Val Lys Lys Cys Thr Leu Asn Pro Ile
             420                 425                 430        
 Phe Asn Glu Ser Phe Ile Tyr Asp Ile Pro Thr Asp Leu Leu Pro Asp
         435                 440                 445            
 Ile Ser Ile Glu Phe Leu Val Ile Asp Phe Asp Arg Thr Thr Lys Asn
     450                 455                 460                
 Glu Val Val Gly Arg Leu Ile Leu Gly Ala His Ser Val Thr Ala Ser
 465                 470                 475                 480
 Gly Ala Glu His Trp Arg Glu Val Cys Glu Ser Pro Arg Lys Pro Val
                 485                 490                 495    
 Ala Lys Trp His Ser Leu Ser Glu Tyr
             500                 505



      <210> 1770
      <211> 395
      <212> PRT
      <213> Homo sapiens


      <400> 1770
 Met Ile Leu Leu Asn Asn Cys Gln Met Leu Leu Ala Leu Tyr Glu Ser
   1               5                  10                  15    
 Leu Ala Val Ser Ile Pro Glu Ser Leu Lys Glu Pro Leu Gln His Gly
              20                  25                  30        
 Gly Ala Gly Gly Leu Leu Ala Arg Val Ser Asp Ser Tyr Tyr Pro Thr
          35                  40                  45            
 Thr Lys Thr Gly Leu Gln Glu Ser Leu Gly Glu Gly Ile Arg Ala Ala
      50                  55                  60                
 Ala Phe Ser Lys Ser Val Lys Val Glu His Ser Arg Ala Phe Leu Cys
  65                  70                  75                  80
 Ile Met Glu Asp Ile Leu Lys Leu Asn Ala Cys Asn Lys Ser Lys Leu
                  85                  90                  95    
 Gly Ser Arg Asp Glu Ile Gly His Pro Asp Asp Glu Phe Glu Arg Lys
             100                 105                 110        
 Glu Ser Pro Glu Asn Gln Val Gly Trp Pro Cys Gly Leu Cys Tyr Gly
         115                 120                 125            
 Asn Asp Thr Cys Cys Ala Ser Phe Leu Leu Leu Phe Leu Thr Ser Ser
     130                 135                 140                
 Ser Leu Val Lys His Ser Thr Gly Gln Gly Val Ala Cys Lys Tyr Gly
 145                 150                 155                 160
 Tyr Lys Phe Ser Ala Trp Cys Leu Gln His Cys Tyr Leu Lys Gly Ser
                 165                 170                 175    
 Gly Ala Phe Leu Gly Glu Val Thr Thr Lys Ser Ala Gly Ile Leu Ser
             180                 185                 190        
 Leu Ser Leu Glu Ala Pro Gly Pro His His Asp His His Leu Ser Gly
         195                 200                 205            
 Ala Ser Thr Ala Asp Ile Glu Ala Lys Lys Lys Ser Phe Arg Gln Leu
     210                 215                 220                
 Met Trp Val Ser Ser Leu Ala Pro Ser Ala Gly Ser Thr Arg Glu Tyr
 225                 230                 235                 240
 Thr Lys Arg Gly Asn Ala Pro Ser Pro Ala Leu Ser Asn Cys Lys Ser
                 245                 250                 255    
 Arg Ala Glu Leu Ala Leu Ser Val Phe Ala Ser Pro Ser Thr Lys Leu
             260                 265                 270        
 Asp His Leu Arg Ser Arg Pro Ser Pro Ser Arg Pro His Ala Asp Ala
         275                 280                 285            
 Gly Ala Ala Cys Ser Ala Thr Cys Ser Gln Leu Glu Ala Gly Pro Leu
     290                 295                 300                
 His His Gln Gly Gly Ala Leu Ser Ala Ala Ala Ala Gly Ser Arg Leu
 305                 310                 315                 320
 Asp Ala Arg Pro Ala Thr Ala Ala Asp Pro Ser Ala Ala Glu Gly Gln
                 325                 330                 335    
 Gln Trp Pro His Thr Glu Ala Pro Trp Arg Ala Ile Pro Leu Ala Ala
             340                 345                 350        
 Leu Leu Ser Ala Leu Leu Pro Leu Ala Ile Lys Arg Arg Lys Lys Arg
         355                 360                 365            
 Glu Thr Ala Arg His Leu Pro Tyr Pro Pro Gly Cys Arg Ala Thr Pro
     370                 375                 380                
 Pro Trp Leu Pro Leu Gly Asp Arg Gly Arg Arg
 385                 390                 395



      <210> 1771
      <211> 1354
      <212> PRT
      <213> Homo sapiens


      <400> 1771
 Met Met Gln Leu Leu Gln Leu Leu Leu Gly Leu Leu Gly Pro Gly Gly
   1               5                  10                  15    
 Tyr Leu Phe Leu Leu Gly Asp Cys Gln Glu Val Thr Thr Leu Thr Val
              20                  25                  30        
 Lys Tyr Gln Val Ser Glu Glu Val Pro Ser Gly Thr Val Ile Gly Lys
          35                  40                  45            
 Leu Ser Gln Glu Leu Gly Arg Glu Glu Arg Arg Arg Gln Ala Gly Ala
      50                  55                  60                
 Ala Phe Gln Val Leu Gln Leu Pro Gln Ala Leu Pro Ile Gln Val Asp
  65                  70                  75                  80
 Ser Glu Glu Gly Leu Leu Ser Thr Gly Arg Arg Leu Asp Arg Glu Gln
                  85                  90                  95    
 Leu Cys Arg Gln Trp Asp Pro Cys Leu Val Ser Phe Asp Val Leu Ala
             100                 105                 110        
 Thr Gly Asp Leu Ala Leu Ile His Val Glu Ile Gln Val Leu Asp Ile
         115                 120                 125            
 Asn Asp His Gln Pro Arg Phe Pro Lys Gly Glu Gln Glu Leu Glu Ile
     130                 135                 140                
 Ser Glu Ser Ala Ser Leu Arg Thr Arg Ile Pro Leu Asp Arg Ala Leu
 145                 150                 155                 160
 Asp Pro Asp Thr Gly Pro Asn Thr Leu His Thr Tyr Thr Leu Ser Pro
                 165                 170                 175    
 Ser Glu His Phe Ala Leu Asp Val Ile Val Gly Pro Asp Glu Thr Lys
             180                 185                 190        
 His Ala Glu Leu Ile Val Val Lys Glu Leu Asp Arg Glu Ile His Ser
         195                 200                 205            
 Phe Phe Asp Leu Val Leu Thr Ala Tyr Asp Asn Gly Asn Pro Pro Lys
     210                 215                 220                
 Ser Gly Thr Ser Leu Val Lys Val Asn Val Leu Asp Ser Asn Asp Asn
 225                 230                 235                 240
 Ser Pro Ala Phe Ala Glu Ser Ser Leu Ala Leu Glu Ile Gln Glu Asp
                 245                 250                 255    
 Ala Ala Pro Gly Thr Leu Leu Ile Lys Leu Thr Ala Thr Asp Pro Asp
             260                 265                 270        
 Gln Gly Pro Asn Gly Glu Val Glu Phe Phe Leu Ser Lys His Met Pro
         275                 280                 285            
 Pro Glu Val Leu Asp Thr Phe Ser Ile Asp Ala Lys Thr Gly Gln Val
     290                 295                 300                
 Ile Leu Arg Arg Pro Leu Asp Tyr Glu Lys Asn Pro Ala Tyr Glu Val
 305                 310                 315                 320
 Asp Val Gln Ala Arg Asp Leu Gly Pro Asn Pro Ile Pro Ala His Cys
                 325                 330                 335    
 Lys Val Leu Ile Lys Val Leu Asp Val Asn Asp Asn Ile Pro Ser Ile
             340                 345                 350        
 His Val Thr Trp Ala Ser Gln Pro Ser Leu Val Ser Glu Ala Leu Pro
         355                 360                 365            
 Lys Asp Ser Phe Ile Ala Leu Val Met Ala Asp Asp Leu Asp Ser Gly
     370                 375                 380                
 His Asn Gly Leu Val His Cys Trp Leu Ser Gln Glu Leu Gly His Phe
 385                 390                 395                 400
 Arg Leu Lys Arg Thr Asn Gly Asn Thr Tyr Met Leu Leu Thr Asn Ala
                 405                 410                 415    
 Thr Leu Asp Arg Glu Gln Trp Pro Lys Tyr Thr Leu Thr Leu Leu Ala
             420                 425                 430        
 Gln Asp Gln Gly Leu Gln Pro Leu Ser Ala Lys Lys Gln Leu Ser Ile
         435                 440                 445            
 Gln Ile Ser Asp Ile Asn Asp Asn Ala Pro Val Phe Glu Lys Ser Arg
     450                 455                 460                
 Tyr Glu Val Ser Thr Arg Glu Asn Asn Leu Pro Ser Leu His Leu Ile
 465                 470                 475                 480
 Thr Ile Lys Ala His Asp Ala Asp Leu Gly Ile Asn Gly Lys Val Ser
                 485                 490                 495    
 Tyr Arg Ile Gln Asp Ser Pro Val Ala His Leu Val Ala Ile Asp Ser
             500                 505                 510        
 Asn Thr Gly Glu Val Thr Ala Gln Arg Ser Leu Asn Tyr Glu Glu Met
         515                 520                 525            
 Ala Gly Phe Glu Phe Gln Val Ile Ala Glu Asp Ser Gly Gln Pro Met
     530                 535                 540                
 Leu Ala Ser Ser Val Ser Val Trp Val Ser Leu Leu Asp Ala Asn Asp
 545                 550                 555                 560
 Asn Ala Pro Glu Val Val Gln Pro Val Leu Ser Asp Gly Lys Ala Ser
                 565                 570                 575    
 Leu Ser Val Leu Val Asn Ala Ser Thr Gly His Leu Leu Val Pro Ile
             580                 585                 590        
 Glu Thr Pro Asn Gly Leu Gly Pro Ala Gly Thr Asp Thr Pro Pro Leu
         595                 600                 605            
 Ala Thr His Ser Ser Arg Pro Phe Leu Leu Thr Thr Ile Val Ala Arg
     610                 615                 620                
 Asp Ala Asp Ser Gly Ala Asn Gly Glu Pro Leu Tyr Ser Ile Arg Ser
 625                 630                 635                 640
 Gly Asn Glu Ala His Leu Phe Ile Leu Asn Pro His Thr Gly Gln Leu
                 645                 650                 655    
 Phe Val Asn Val Thr Asn Ala Ser Ser Leu Ile Gly Ser Glu Trp Glu
             660                 665                 670        
 Leu Glu Ile Val Val Glu Asp Gln Gly Ser Pro Pro Leu Gln Thr Arg
         675                 680                 685            
 Ala Leu Leu Arg Val Met Phe Val Thr Ser Val Asp His Leu Arg Asp
     690                 695                 700                
 Ser Ala Arg Lys Pro Gly Ala Leu Ser Met Ser Met Leu Thr Val Ile
 705                 710                 715                 720
 Cys Leu Ala Val Leu Leu Gly Ile Phe Gly Leu Ile Leu Ala Leu Phe
                 725                 730                 735    
 Met Ser Ile Cys Arg Thr Glu Lys Lys Asp Asn Arg Ala Tyr Asn Cys
             740                 745                 750        
 Arg Glu Ala Glu Ser Thr Tyr Arg Gln Gln Pro Lys Arg Pro Gln Lys
         755                 760                 765            
 His Ile Gln Lys Ala Asp Ile His Leu Val Pro Val Leu Arg Gly Gln
     770                 775                 780                
 Ala Gly Glu Pro Cys Glu Val Gly Gln Ser His Lys Asp Val Asp Lys
 785                 790                 795                 800
 Glu Ala Met Met Glu Ala Gly Trp Asp Pro Cys Leu Gln Ala Pro Phe
                 805                 810                 815    
 His Leu Thr Pro Thr Leu Tyr Arg Thr Leu Arg Asn Gln Gly Asn Gln
             820                 825                 830        
 Gly Ala Pro Ala Glu Ser Arg Glu Val Leu Gln Asp Thr Val Asn Leu
         835                 840                 845            
 Leu Phe Asn His Pro Arg Gln Arg Asn Ala Ser Arg Glu Asn Leu Asn
     850                 855                 860                
 Leu Pro Glu Pro Gln Pro Ala Thr Gly Gln Pro Arg Ser Arg Pro Leu
 865                 870                 875                 880
 Lys Val Ala Gly Ser Pro Thr Gly Arg Leu Ala Gly Asp Gln Gly Ser
                 885                 890                 895    
 Glu Glu Ala Pro Gln Arg Pro Pro Ala Ser Ser Ala Thr Leu Arg Arg
             900                 905                 910        
 Gln Arg His Leu Asn Gly Lys Val Ser Pro Glu Lys Glu Ser Gly Pro
         915                 920                 925            
 Arg Gln Ile Leu Arg Ser Leu Val Arg Leu Ser Val Ala Ala Phe Ala
     930                 935                 940                
 Glu Arg Asn Pro Val Glu Glu Leu Thr Val Asp Ser Pro Pro Val Gln
 945                 950                 955                 960
 Gln Ile Ser Gln Leu Leu Ser Leu Leu His Gln Gly Gln Phe Gln Pro
                 965                 970                 975    
 Lys Pro Asn His Arg Gly Asn Lys Tyr Leu Ala Lys Pro Gly Gly Ser
             980                 985                 990        
 Arg Ser Ala Ile Pro Asp Thr Asp Gly Pro Ser Ala Arg Ala Gly Gly
         995                1000                1005            
 Gln Thr Asp Pro Glu Gln Glu Glu Gly Pro Leu Asp Pro Glu Glu Asp
    1010                1015                1020                
 Leu Ser Val Lys Gln Leu Leu Glu Glu Glu Leu Ser Ser Leu Leu Asp
1025                1030                1035                1040
 Pro Ser Thr Asp Leu Leu Gln Ile Ala Ser Asp Leu Leu Leu Arg Ile
                1045                1050                1055    
 Gln Ile Ala Pro Leu Glu Asn Ala Thr Met Ile Met Phe Ser Trp Leu
            1060                1065                1070        
 His Glu Leu Thr Glu Pro His Asn Asn Ser Thr Arg Tyr Val Leu Leu
        1075                1080                1085            
 Ser His His Phe Leu Arg Gly Asn Gly Ser Leu Glu Arg Leu Ser His
    1090                1095                1100                
 Phe Pro Lys Val Thr His Thr Ala Pro Lys Leu Gln Ser Trp Glu Ile
1105                1110                1115                1120
 Lys Pro Arg Leu Ala Gln Cys Pro Pro Ala Ala Arg Thr Gly Leu Ala
                1125                1130                1135    
 Leu Asp Arg Leu Ser Ala Pro Asp Pro Ala Trp Met Ala Arg Leu Ser
            1140                1145                1150        
 Leu Pro Leu Thr Thr Asn Tyr Arg Asp Asn Val Ile Ser Pro Asp Ala
        1155                1160                1165            
 Ala Ala Thr Glu Glu Pro Arg Thr Phe Gln Thr Phe Gly Lys Ala Glu
    1170                1175                1180                
 Ala Pro Glu Leu Ser Pro Thr Gly Thr Arg Leu Ala Ser Thr Phe Val
1185                1190                1195                1200
 Ser Glu Met Ser Ser Leu Leu Glu Met Leu Leu Glu Gln Arg Ser Ser
                1205                1210                1215    
 Met Pro Val Glu Ala Ala Ser Glu Ala Leu Arg Arg Leu Ser Gly Tyr
            1220                1225                1230        
 Thr His Gln Thr Leu Ala Asn Ser Ser Thr Asp Leu Ser Val Arg Lys
        1235                1240                1245            
 Pro Arg His Lys Lys Glu Glu Val Lys Leu Leu Gly Arg Val Val Tyr
    1250                1255                1260                
 Thr Phe Ser Pro Cys Phe Tyr Asn Thr Gln Ala Lys Ser Leu Ser Asn
1265                1270                1275                1280
 Lys His Asp Arg Leu Met Pro Thr Asp His Val Thr Thr Gln Gln Trp
                1285                1290                1295    
 Thr His Ala Ser Ser Pro Thr Cys Leu Ser Thr Glu Ile Ala Tyr Pro
            1300                1305                1310        
 Ile Val Gly Cys Lys Pro Lys Ile Phe His Ser Ser Leu Leu Ile Gln
        1315                1320                1325            
 Glu Val Glu Ser Asp Gly Asn Thr Glu Leu Glu Glu Leu Leu Asn Gly
    1330                1335                1340                
 Ser His Ser Leu Leu Lys Gly Lys Ser Phe
1345                1350                



      <210> 1772
      <211> 135
      <212> PRT
      <213> Homo sapiens

      <220>
      <221> misc_feature
      <222> (1)...(135)
      <223> Xaa = any amino acid or nothing 


      <400> 1772
 Met Glu Ser Ala Leu Pro Ala Ala Gly Phe Leu Tyr Trp Val Gly Ala
   1               5                  10                  15    
 Gly Thr Val Ala Tyr Leu Ala Leu Arg Ile Ser Tyr Ser Leu Phe Thr
              20                  25                  30        
 Ala Leu Arg Val Trp Gly Val Gly Asn Glu Xaa Gly Gly Arg Pro Gly
          35                  40                  45            
 Ala Arg Arg Met Gly Arg Arg Thr Lys Gly Asp Pro Val Asn Val Glu
      50                  55                  60                
 Phe Gln Val Phe Glu Glu Thr Ile Ser Val Trp Gly Lys Ser Leu Ile
  65                  70                  75                  80
 Thr Val Val Trp Glu Val Leu Leu Leu Gln Gly Leu Ser Asp Gly Val
                  85                  90                  95    
 Ile Glu Thr Leu Lys Leu Gly Tyr Cys Val Val Met Arg Val Leu Asp
             100                 105                 110        
 Phe Leu Ile Phe Ala Asn Tyr Val Ile Val Leu Leu Val Met Lys Leu
         115                 120                 125            
 Gln Ile Arg Asp Gly Lys Phe
     130                 135



      <210> 1773
      <211> 187
      <212> PRT
      <213> Homo sapiens


      <400> 1773
 Met Gly Pro Leu Met Leu Asn Ala Ile Leu Leu Leu Leu Val Leu Ile
   1               5                  10                  15    
 Arg Trp Gly Cys Gln Leu Leu Phe Ala Ser Cys Pro Asp Val Leu Ser
              20                  25                  30        
 Lys Leu Ile Ile Thr Met Gly Leu Trp Thr Ile Leu Asp Pro Leu Ala
          35                  40                  45            
 Val Phe Ile Leu Asp Thr Leu Leu Gly Arg Leu Thr Asp Asn Glu Glu
      50                  55                  60                
 Thr Pro Val Ala Asp Ala Ala Lys Leu Tyr Trp Met Phe Val Arg Thr
  65                  70                  75                  80
 Val Gln Pro Gly Ile Leu Gly Val Val Ile Thr Val Leu Leu Tyr Ile
                  85                  90                  95    
 Leu Leu Phe Val Ile Ser Ser Leu Ile Leu Tyr Leu Tyr Cys Leu Ser
             100                 105                 110        
 Thr Ile Tyr Asn Ser Lys Asp Met Glu Pro Thr Lys Cys Pro Ser Val
         115                 120                 125            
 Ile Asp Trp Met Lys Lys Val Trp Tyr Ile Cys Thr Met Glu Tyr Ser
     130                 135                 140                
 Ala Ala Ile Lys Arg Asn Glu Ile Met Ser Phe Ser Gly Thr Trp Met
 145                 150                 155                 160
 Lys Leu Glu Ala Ile Ile Leu Ser Lys Leu Thr Gln Glu Gln Lys Thr
                 165                 170                 175    
 Lys His Cys Met Phe Ser Leu Ile Ser Gly Ser
             180                 185        



      <210> 1774
      <211> 1425
      <212> PRT
      <213> Homo sapiens


      <400> 1774
 Met Thr Gly Leu Ser Ala Ser Leu Leu Gly Ile Ser Ser Pro Cys Leu
   1               5                  10                  15    
 Phe Arg Arg Cys Cys Ser Leu Pro Ser Val His Ser Cys Ser Leu Pro
              20                  25                  30        
 Ser Val Arg Ser Cys Ser Leu Pro Ser Val Arg Ser Cys Ser Leu Pro
          35                  40                  45            
 Ser Leu Cys Ser Cys Ser Leu Pro Ser Val His Ser Cys Ser Leu Pro
      50                  55                  60                
 Ser Leu Phe Leu Gln Pro Ala Pro Ser Val Phe Leu Gln Pro Ala Leu
  65                  70                  75                  80
 Ser Val Phe Leu Gln Pro Ala Leu Ser Val Phe Leu Gln Pro Ala Leu
                  85                  90                  95    
 Ser Val Phe Leu Gln Pro Ala Leu Ser Val Phe Leu Gln Pro Ala Leu
             100                 105                 110        
 Arg Ala Phe Leu Gln Pro Ala Leu Arg Ala Phe Leu Gln Pro Ala Leu
         115                 120                 125            
 Cys Ala Phe Leu Gln Pro Ala Leu Ser Val Phe Leu Gln Pro Ala Leu
     130                 135                 140                
 Ser Val Phe Leu Gln Pro Ala Leu Ser Val Phe Leu Gln Pro Ala Leu
 145                 150                 155                 160
 Ser Val Phe Leu Gln Pro Ala Leu Arg Ala Phe Leu Gln Pro Ala Leu
                 165                 170                 175    
 Pro Val Phe Leu Gln Pro Ala Leu Cys Ala Phe Leu Gln Pro Ala Leu
             180                 185                 190        
 Arg Ala Phe Leu Gln Pro Ala Leu Ser Val Phe Leu Gln Pro Ala Leu
         195                 200                 205            
 Arg Ala Phe Leu Gln Pro Ala Leu Pro Val Phe Leu Gln Pro Ala Leu
     210                 215                 220                
 Arg Ala Phe Leu Gln Pro Ala Leu Ser Val Phe Leu Gln Pro Ala Leu
 225                 230                 235                 240
 Ser Val Phe Leu Gln Pro Ala Leu Arg Ala Phe Leu Gln Pro Ala Leu
                 245                 250                 255    
 Arg Ala Phe Leu Gln Pro Ala Leu Ser Cys Pro Val Phe Leu Gln Pro
             260                 265                 270        
 Ala Leu Ser Val Phe Leu Gln Pro Ala Leu Ser Val Phe Leu Gln Pro
         275                 280                 285            
 Ala Leu Arg Ala Phe Leu Gln Pro Ala Leu Ser Val Phe Leu Gln Pro
     290                 295                 300                
 Ala Leu Pro Val Phe Leu Gln Pro Ala Leu Arg Ala Phe Leu Gln Pro
 305                 310                 315                 320
 Ala Leu Pro Val Phe Leu Gln Pro Ala Leu Pro Val Phe Leu Gln Pro
                 325                 330                 335    
 Ala Leu Cys Ala Phe Leu Gln Leu Ala Leu Ser Cys Pro Val Phe Leu
             340                 345                 350        
 Gln Pro Ala Leu Ser Val Phe Leu Gln Pro Ala Leu Arg Ala Phe Leu
         355                 360                 365            
 Gln Pro Ala Leu Pro Val Phe Leu Gln Pro Ala Leu Pro Val Phe Leu
     370                 375                 380                
 Gln Pro Ala Leu Arg Ala Phe Leu Gln Pro Ala Leu Pro Val Phe Leu
 385                 390                 395                 400
 Gln Pro Ala Leu Pro Val Phe Leu Gln Pro Ala Leu Ser Pro Ala Val
                 405                 410                 415    
 Pro Ser Ser Pro Ala Gly Ile Phe Gly His Ile Ala Val Ile Gly Ser
             420                 425                 430        
 Pro Phe Pro Thr Ala Gly Gly Asn Thr Ser Asp Ser Phe Ser Asn Gly
         435                 440                 445            
 Cys Ser Gln Asp Val Gly Ser Pro Arg Leu Cys Gly Cys Gly Leu Leu
     450                 455                 460                
 Gly Val Gly Ile Trp Leu Ser Val Ser Gln Gly Asn Phe Ala Thr Phe
 465                 470                 475                 480
 Ser Pro Ser Phe Pro Ser Leu Ser Ala Ala Asn Leu Val Ile Ala Ile
                 485                 490                 495    
 Gly Thr Ile Val Met Val Thr Gly Phe Leu Gly Cys Leu Gly Ala Ile
             500                 505                 510        
 Lys Glu Asn Lys Cys Leu Leu Leu Ser Phe Phe Ile Val Leu Leu Val
         515                 520                 525            
 Ile Leu Leu Ala Glu Leu Ile Leu Leu Ile Leu Phe Phe Val Tyr Met
     530                 535                 540                
 Asp Lys Val Asn Glu Asn Ala Lys Lys Asp Leu Lys Glu Gly Leu Leu
 545                 550                 555                 560
 Leu Tyr His Thr Glu Asn Asn Val Gly Leu Lys Asn Ala Trp Asn Ile
                 565                 570                 575    
 Ile Gln Ala Glu Gly Gly His Phe Cys Gly Asp Trp Gly Trp Pro Gly
             580                 585                 590        
 Gln Gly Lys Ala Leu Gly Arg Lys Gly Arg Ala Met Ala Cys Leu Thr
         595                 600                 605            
 Ala Pro Ser Ile Pro Ala Gly Gln Met Arg Cys Cys Gly Val Thr Asp
     610                 615                 620                
 Tyr Thr Asp Trp Tyr Pro Val Leu Gly Glu Asn Thr Val Pro Asp Arg
 625                 630                 635                 640
 Cys Cys Met Glu Asn Ser Gln Gly Cys Gly Arg Asn Ala Thr Thr Pro
                 645                 650                 655    
 Leu Trp Arg Thr Gly Cys Tyr Glu Lys Val Lys Met Trp Phe Asp Asp
             660                 665                 670        
 Asn Lys His Val Leu Gly Thr Val Gly Met Cys Ile Leu Ile Met Gln
         675                 680                 685            
 Ile Leu Gly Met Ala Phe Ser Met Thr Leu Phe Gln His Ile His Arg
     690                 695                 700                
 Thr Asp Ser Gln Arg Leu Leu Leu Trp Pro Leu Ser Glu Arg Leu Asn
 705                 710                 715                 720
 Ile Gly Gln Gly Gly Pro Glu Asp Thr Gly Glu Arg Gly Arg Ala Gly
                 725                 730                 735    
 Ala Leu Val Arg Ser Gly Ser Pro Leu Asp Leu Gly Trp Ile His Leu
             740                 745                 750        
 Phe Thr Gln His Val Ala Arg Leu Arg Arg Val His Thr Thr Pro Gly
         755                 760                 765            
 Trp Leu Arg Ile Leu Val Asn Gly Val Lys Ile Leu Thr Asp Gln Arg
     770                 775                 780                
 Gln Lys Ala Leu Gln Gly Thr Gln Phe Lys Tyr Thr Cys Leu Ser Leu
 785                 790                 795                 800
 Ala Leu Ala Asp Ser Gln Glu Leu Met Thr Leu Val Ser Arg Arg Ser
                 805                 810                 815    
 Gln Phe Lys Gln Ile Met Thr Arg Ala Asp Arg Arg Ala Gln Ser Gly
             820                 825                 830        
 Gln Tyr Thr Glu His Val Phe Lys Ala Gly Pro Arg Val Gly Gly Gly
         835                 840                 845            
 Asp Gly Asp Cys Ser Thr Ser Leu Pro Leu Pro Glu Ile Leu Glu Glu
     850                 855                 860                
 Gly Pro Gly Val Ala Asp Ser Glu Thr Lys Ala Gly Asn Arg Ala Gly
 865                 870                 875                 880
 Gly Ser Arg Ala His His Thr Asp Ile Pro Trp Pro Pro Cys Pro Gln
                 885                 890                 895    
 Gly His Ile Gly Pro Phe Trp Leu Ser Gly Pro Leu Ala Val His Lys
             900                 905                 910        
 Ala Ala Gly Leu Asp Met Glu Val Val Phe Pro Arg Ser Ser Gly Leu
         915                 920                 925            
 Ser Tyr His Phe Leu Gln Leu Gly Pro Ala Asn Leu Pro Asn Gly Asn
     930                 935                 940                
 Leu Gly Trp Thr Thr Ala Ser Ala Gly Ile Thr Ala Asn Pro Ala Ser
 945                 950                 955                 960
 Asn Ser Gly Thr Lys Leu Arg Ser Val Met Asp Ala Leu Pro Cys Ala
                 965                 970                 975    
 Arg Ala Met Gly Glu Thr Glu Thr Leu Gly Gly Ala Pro Arg Ala Val
             980                 985                 990        
 Ile Ser Ser Asp Thr Glu Pro Gly Ala Val Ala Gln Ser Ser Pro Ala
         995                1000                1005            
 Pro Val Pro Ser Gly Asp Ser Ser Gly Val Gln His Met Gly Gln Lys
    1010                1015                1020                
 Thr Cys Pro Gly Glu Val Gln Lys Ser Gly Asn Ala Asn Ala Thr Trp
1025                1030                1035                1040
 Ala Pro Trp Pro Cys Arg Pro Leu Ser Arg Gly Arg Glu Phe Ala Lys
                1045                1050                1055    
 Ala Lys Gly Gln Tyr Gln Glu Ile Gly Ala Pro Phe Gln Gly Thr Val
            1060                1065                1070        
 Leu Ile Ala Leu Asp Gly Glu Gly Leu Ala Cys Ala Gly Ala Leu Thr
        1075                1080                1085            
 Thr Pro Leu Gln Met Leu Glu Gly Trp Ala Gly Trp Leu Gln Ser Ala
    1090                1095                1100                
 Thr Thr Ala Leu Gln Pro Leu Ser Gly Thr Gly Gly Ser His Leu Pro
1105                1110                1115                1120
 Arg Gln Gln Gln Ser Arg Lys Ala Glu Asn Val Leu Glu Met Leu Val
                1125                1130                1135    
 Glu Ala Asp Val Ser Gly Ser Pro Ser Val Gln Asp Gly Ala Ser Val
            1140                1145                1150        
 Ala Glu Asn Cys Arg Glu Val Val Trp Lys Leu Ile Gly Cys Lys Asn
        1155                1160                1165            
 Cys Ser Ala Ala Thr Val Leu Leu Glu Val Val Val Asn Arg Asp Tyr
    1170                1175                1180                
 Trp Pro Leu Arg Ala Pro Gln Asn Gln Gly Ser Gly Ser Glu Glu Arg
1185                1190                1195                1200
 Phe Gln Val Arg Ala Ser Ala Phe Pro Leu Val Leu Ser Arg Glu His
                1205                1210                1215    
 Gly Glu Ala Ala Leu Leu Leu Leu Gly Asp Gly Ala Val Ala Gln Glu
            1220                1225                1230        
 Ala Gly His His Asp Glu Ser Thr Arg Ser Asp Glu Asp Ala Gly Gly
        1235                1240                1245            
 Gly Gly Glu Gly Ala Gly Gly Gln Asp Ala Glu Ile Leu Thr Ala Lys
    1250                1255                1260                
 Arg Gly Arg Gly Ala Pro Lys Ala Val Gly Ser Pro Met Pro Phe Ser
1265                1270                1275                1280
 Ile Ser Arg Ser Gly Ala Ala Glu Lys Pro Ala Thr Arg Ser Leu Thr
                1285                1290                1295    
 Cys Phe Ser Ser Asn Gly Lys Pro Arg Lys Gly Ala Glu Ala Thr Phe
            1300                1305                1310        
 Ser Gly Val Met Leu Ser Glu Val Lys Gly Phe Leu Ala Leu Ala Lys
        1315                1320                1325            
 Arg Arg Thr Gln Glu Lys Tyr Phe Thr Ser Phe Asn Pro Ile Lys Leu
    1330                1335                1340                
 Thr Leu Ser Val Asn His His Ser Ile Ile Tyr Arg Lys Asp Asn Gly
1345                1350                1355                1360
 Pro Lys Arg Thr Gly Tyr Gly Pro Gln Glu Asp Ile Thr Gln Ala Gly
                1365                1370                1375    
 Phe Leu Arg Gly Val Thr Ile Glu Thr Ile Ser Ile Thr Gly Ser Ser
            1380                1385                1390        
 Ser Leu Ser Phe Arg Asp Phe Cys Phe Pro Ala Leu Gly Leu Glu Asn
        1395                1400                1405            
 Val Asn His Glu Arg Gln Met Gly Phe Gly Tyr Thr Gln Thr Gly Val
    1410                1415                1420                
 Gln
1425



      <210> 1775
      <211> 334
      <212> PRT
      <213> Homo sapiens


      <400> 1775
 Met Val Thr Glu Phe Leu Leu Leu Gly Phe Ser Ser Leu Gly Glu Ile
   1               5                  10                  15    
 Gln Leu Ala Leu Phe Val Val Phe Leu Phe Leu Tyr Leu Val Ile Leu
              20                  25                  30        
 Ser Gly Asn Val Thr Ile Ile Ser Val Ile His Leu Asp Lys Ser Leu
          35                  40                  45            
 His Thr Pro Met Tyr Phe Phe Leu Gly Ile Leu Ser Thr Ser Glu Thr
      50                  55                  60                
 Phe Tyr Thr Phe Val Ile Leu Pro Lys Met Leu Ile Asn Leu Leu Ser
  65                  70                  75                  80
 Val Ala Arg Thr Ile Ser Phe Asn Cys Cys Ala Leu Gln Met Phe Phe
                  85                  90                  95    
 Phe Leu Gly Phe Ala Ile Thr Asn Cys Leu Leu Leu Gly Val Met Gly
             100                 105                 110        
 Tyr Asp Arg Tyr Ala Ala Ile Cys His Pro Leu His Tyr Pro Thr Leu
         115                 120                 125            
 Met Ser Trp Gln Ala Ser Asn Cys Arg Phe Leu His Ser Asp Phe Ser
     130                 135                 140                
 Gly Ile Leu Ser Ile Ser Glu Ile Phe Tyr Thr Thr Val Ile Leu Pro
 145                 150                 155                 160
 Lys Met Leu Ile Asn Leu Phe Ser Val Phe Arg Thr Leu Ser Phe Val
                 165                 170                 175    
 Ser Cys Ala Thr Gln Met Phe Phe Phe Leu Gly Phe Ala Val Thr Asn
             180                 185                 190        
 Cys Leu Leu Leu Gly Val Met Gly Tyr Asp Arg Tyr Ala Ala Ile Cys
         195                 200                 205            
 Gln Pro Leu Gln Tyr Ala Val Leu Met Ser Trp Arg Val Cys Gly Gln
     210                 215                 220                
 Leu Ile Ala Thr Cys Ile Ile Ser Gly Phe Leu Ile Ser Leu Val Gly
 225                 230                 235                 240
 Thr Thr Phe Val Phe Ser Leu Pro Phe Cys Gly Ser Asn Lys Val Asn
                 245                 250                 255    
 His Tyr Phe Cys Asp Ile Ser Pro Val Ile Arg Leu Ala Cys Ala Asp
             260                 265                 270        
 Ser Tyr Ile Ser Glu Leu Val Ile Phe Ile Phe Gly Val Leu Val Leu
         275                 280                 285            
 Val Val Pro Leu Ile Phe Ile Cys Ile Ser Tyr Gly Phe Ile Val Arg
     290                 295                 300                
 Thr Ile Leu Lys Ile Pro Ser Ala Glu Gly Lys Gln Lys Ala Phe Ser
 305                 310                 315                 320
 Thr Cys Ala Ser His Leu Ile Val Val Ile Val His Tyr Gly
                 325                 330                



      <210> 1776
      <211> 109
      <212> PRT
      <213> Homo sapiens


      <400> 1776
 Met Ser Glu Asn Met Arg Cys Leu Val Phe Cys Pro Cys Asp Ser Leu
   1               5                  10                  15    
 Leu Arg Met Met Val Ser Ser Phe Ile His Val Leu Met Ile Trp Leu
              20                  25                  30        
 Ser Val Cys Leu Leu Leu Val Tyr Arg Asn Ala Cys Asp Phe Cys Ile
          35                  40                  45            
 Ser Ile Leu Tyr Pro Glu Thr Leu Leu Gln Leu Leu Ile Ser Leu Arg
      50                  55                  60                
 Arg Phe Trp Ala Glu Thr Met Gly Leu Ser Lys Tyr Thr Ile Met Ser
  65                  70                  75                  80
 Ser Cys Ser Ser Ile Leu Asp Cys Cys Ala Ser Ser Glu Arg Gly Ser
                  85                  90                  95    
 Val Gly Val Gly Pro Ser Gln Pro Ala Arg Cys Gly Ile
             100                 105                



      <210> 1777
      <211> 183
      <212> PRT
      <213> Homo sapiens


      <400> 1777
 Met Ala Arg Leu Gln Leu Pro Pro Gln Gly Trp Gln Gly Ala Leu Gly
   1               5                  10                  15    
 Gln Val Ala Ala Trp Trp Thr Pro Gly Thr Ala Leu Gly Ile Cys His
              20                  25                  30        
 Val Thr Lys Ala Cys Val Ala Leu His Tyr Asn Thr Thr Ala Gln Leu
          35                  40                  45            
 Ser Arg Gln Leu Val Thr Leu Phe Ser Val Pro Pro Gln Glu Pro Gly
      50                  55                  60                
 Arg Glu Ser Gly Pro Gly His Ser Arg Leu Arg Glu Pro Arg Ala Glu
  65                  70                  75                  80
 Met Glu Thr Val Gln Glu Leu Ile Pro Leu Ala Lys Glu Met Met Ala
                  85                  90                  95    
 Gln Lys Arg Lys Gly Lys Met Val Lys Leu Tyr Val Leu Gly Ser Val
             100                 105                 110        
 Leu Ala Leu Phe Gly Val Val Leu Gly Leu Met Glu Thr Val Cys Ser
         115                 120                 125            
 Pro Phe Thr Ala Ala Arg Arg Leu Arg Asp Gln Glu Ala Ala Val Ala
     130                 135                 140                
 Glu Leu Gln Ala Ala Leu Glu Arg Gln Ala Leu Gln Lys Gln Ala Leu
 145                 150                 155                 160
 Gln Glu Lys Gly Lys Gln Gln Asp Thr Val Leu Gly Gly Arg Ala Leu
                 165                 170                 175    
 Ser Asn Arg Gln His Ala Ser
             180            



      <210> 1778
      <211> 250
      <212> PRT
      <213> Homo sapiens


      <400> 1778
 Met Ser Glu His Phe Lys Thr Thr Ser Gln Lys Val Ala Arg Lys Phe
   1               5                  10                  15    
 Trp Trp Lys Asn Val Lys Met Ile Val Leu Ile Cys Val Ile Val Phe
              20                  25                  30        
 Ile Ile Ile Leu Phe Ile Val Leu Phe Ala Thr Glu Asn Ala Ala Arg
          35                  40                  45            
 Ser Ser Tyr Pro Ser Ser Arg Gly Pro Ala Ala Met Leu Tyr Ala Pro
      50                  55                  60                
 Glu Gly Leu Lys Asn Lys Asn Phe Leu Gly Val Leu Ala Tyr Gly Lys
  65                  70                  75                  80
 Phe Lys Thr Phe Ile Ala Phe Trp Gly Gly Gln Trp Glu Thr Leu Gly
                  85                  90                  95    
 Gln Leu Cys Ile Asp Trp Val Asp Ala Ile Leu Glu Gln Ala Gly Ile
             100                 105                 110        
 Glu Leu Glu Arg Cys Gln Gln Gln Ala Asn Glu Val Thr Glu Ile Met
         115                 120                 125            
 Arg Asn Asn Phe Gly Lys Val Leu Glu Arg Gly Val Lys Leu Ala Glu
     130                 135                 140                
 Leu Gln Gln Arg Ser Asp Gln Leu Leu Asp Met Ser Ser Thr Phe Asn
 145                 150                 155                 160
 Lys Thr Thr Gln Asn Leu Ala Gln Lys Lys Cys Trp Glu Asn Ile Arg
                 165                 170                 175    
 Tyr Arg Ile Cys Val Gly Leu Val Val Val Gly Val Leu Leu Ile Ile
             180                 185                 190        
 Leu Ile Val Leu Leu Val Val Phe Leu Pro Gln Ser Arg Leu Leu Lys
         195                 200                 205            
 Lys Pro Ile Thr Gln Arg Thr Pro Pro Leu Gly Asp Gly Ser Phe Leu
     210                 215                 220                
 Ser Leu Pro Tyr Leu Ile Gln Pro Asp Thr Asp Arg Glu Cys Gly Cys
 225                 230                 235                 240
 Lys Asn Thr Met Ala Pro Lys Ala Asp Pro
                 245                 250



      <210> 1779
      <211> 415
      <212> PRT
      <213> Homo sapiens


      <400> 1779
 Met Leu Ala Ala Pro Ser Cys Gly Leu Leu Gly Phe Thr Leu Pro Arg
   1               5                  10                  15    
 Arg Gly Leu Ser Leu Glu Ala Leu Gly Glu His Pro Ser Pro Cys Glu
              20                  25                  30        
 Ser Gly Ala Val Pro Ala Ala Pro Ser Gln Trp Leu Pro Gln Leu Pro
          35                  40                  45            
 Gly Ala Gly Ser Val Leu Ala Met Thr Thr Leu Gln Ala His Leu Ser
      50                  55                  60                
 Pro Leu Leu Pro Arg Lys Leu Ile Asp Asp Val Val Leu Gln Pro Thr
  65                  70                  75                  80
 Ala Ala Gln Val Cys Ser Ala Pro Ser Ser Val Ser Cys Ser Asn Gly
                  85                  90                  95    
 Ile Arg Ala Gly Ser Glu Glu Leu Ser Ala Ala Pro Pro Glu Ala Ile
             100                 105                 110        
 His Arg Tyr Gly Gly Lys Ala Pro Gly Gly Arg Gly Cys Lys Gln Cys
         115                 120                 125            
 Ser Cys Cys Val Tyr Lys Leu Leu Leu Leu Gly Leu Ala Thr Pro Ser
     130                 135                 140                
 Val Arg Gly Cys Gln Gly Leu Leu Glu Ala Gly Ala Thr Ser Gln Gly
 145                 150                 155                 160
 Ala Trp Asp Trp Trp Gly Ser Ser Gln Val Arg His Arg Leu Gly Arg
                 165                 170                 175    
 Ala Pro Val Ser Met Met Leu Leu Thr Glu Asp Glu Gly Cys Ser Arg
             180                 185                 190        
 Ser Ile Cys Lys Pro Gly Met Gly Pro Ser Pro Ser Val Ala His Gly
         195                 200                 205            
 Arg Ser Arg Gln Pro His Pro Ser Gly Leu Asn Met Leu Cys Asp Val
     210                 215                 220                
 Pro Leu Tyr Asp Ile Cys Asp Tyr Asn Val Ser Arg Asp Arg Cys Gln
 225                 230                 235                 240
 Glu Leu Gly Cys Cys Phe Tyr Glu Gly Val Cys Tyr Lys Lys Ala Val
                 245                 250                 255    
 Pro Ser Lys Gln Val Ser Thr Gly Gln Ser Ser Leu Lys Glu Ile Arg
             260                 265                 270        
 Gln Leu Ile Gly Arg Met Phe Asp Lys Gln Phe Pro Ser Val Leu Leu
         275                 280                 285            
 Val Tyr Ile His Val Phe Ser Ala Leu Ile Val Ile Ile Ala Gly Ala
     290                 295                 300                
 Phe Val Ile Thr Ile Ile Tyr Arg Val Ile Gln Glu Ser Arg Lys Glu
 305                 310                 315                 320
 Lys Ala Ile Pro Val Asp Val Ala Leu Pro Gln Lys Ser Ser Glu Lys
                 325                 330                 335    
 Ala Glu Leu Ala Ser Ser Ser Ser Lys Leu Gly Leu Lys Pro Ala Ser
             340                 345                 350        
 Pro Gly Pro Pro Ser Ala Gly Pro Ser Met Lys Ser Asp Glu Asp Lys
         355                 360                 365            
 Asp Asp Gly Pro Ser Ala Ala Trp Leu Cys Gly Cys Ser Val Lys Ala
     370                 375                 380                
 Asp Thr Asp Asp Ala Ser Arg Lys Asp Val Ala Leu Leu Gln Lys Asp
 385                 390                 395                 400
 Phe Leu Met Glu Ala Ser Asp Gly Leu Asp Ala Ala Tyr Lys Leu
                 405                 410                 415



      <210> 1780
      <211> 350
      <212> PRT
      <213> Homo sapiens


      <400> 1780
 Met Gly Val Met Ala Pro Arg Thr Leu Leu Leu Leu Leu Leu Gly Ala
   1               5                  10                  15    
 Leu Ala Leu Thr Glu Thr Trp Ala Gly Ser His Ser Leu Arg Tyr Phe
              20                  25                  30        
 Ser Thr Ala Val Ser Gln Pro Gly Arg Gly Glu Pro Arg Phe Ile Ala
          35                  40                  45            
 Val Gly Tyr Val Asp Asp Thr Glu Phe Val Arg Phe Asp Ser Asp Ser
      50                  55                  60                
 Val Ser Pro Arg Met Glu Arg Arg Ala Pro Trp Val Glu Gln Glu Gly
  65                  70                  75                  80
 Leu Glu Tyr Trp Asp Gln Glu Thr Arg Asn Ala Lys Gly His Ala Gln
                  85                  90                  95    
 Ile Tyr Arg Val Asn Leu Arg Thr Leu Leu Arg Tyr Tyr Asn Gln Ser
             100                 105                 110        
 Glu Ala Glu Glu Ala Trp Leu Arg Arg Gly Pro Asp Arg Arg Leu Leu
         115                 120                 125            
 Arg Arg Tyr Glu Gln Phe Ala Tyr Asp Gly Lys Asp Tyr Ile Ala Leu
     130                 135                 140                
 Asn Glu Asp Leu His Ser Trp Thr Ala Ala Asn Thr Ala Ala Gln Ile
 145                 150                 155                 160
 Ser Gln His Lys Trp Glu Ala Asp Lys Tyr Ser Glu Gln Val Arg Ala
                 165                 170                 175    
 Tyr Leu Arg Ala Asn Pro Pro Lys Ala His Val Thr Gln His Pro Ile
             180                 185                 190        
 Ser Asp His Glu Ala Thr Leu Arg Cys Trp Ala Leu Gly Leu Tyr Pro
         195                 200                 205            
 Ala Glu Ile Thr Leu Thr Trp Gln Gln Asp Gly Glu Asp Gln Thr Gln
     210                 215                 220                
 Asp Thr Glu Leu Val Glu Thr Arg Pro Ala Gly Asp Gly Thr Phe Gln
 225                 230                 235                 240
 Lys Trp Val Ala Val Val Val Pro Ser Gly Glu Glu Gln Arg Tyr Met
                 245                 250                 255    
 Cys His Val Gln His Glu Gly Leu Pro Glu Pro Leu Thr Leu Arg Trp
             260                 265                 270        
 Glu Pro Ser Ser Gln Pro Thr Ile Pro Ile Val Gly Ile Val Ala Gly
         275                 280                 285            
 Leu Phe Leu Leu Gly Ala Val Val Thr Gly Ala Val Val Ala Ala Ala
     290                 295                 300                
 Met Trp Arg Lys Lys Ser Ser Gly Arg Glu Gly Glu Pro Leu Ser Leu
 305                 310                 315                 320
 Leu Leu Ser Thr Asp Ala Thr Ala Tyr Thr Ser Asp Thr Leu Met Ala
                 325                 330                 335    
 Asp Thr Gly Pro Cys Gly Lys Asp Cys Tyr His Cys Cys Ser
             340                 345                 350



      <210> 1781
      <211> 395
      <212> PRT
      <213> Homo sapiens


      <400> 1781
 Met Ala His Ser Lys Gln Pro Ser His Phe Gln Ser Leu Met Leu Leu
   1               5                  10                  15    
 Gln Trp Pro Leu Ser Tyr Leu Ala Ile Phe Trp Ile Leu Gln Pro Leu
              20                  25                  30        
 Phe Val Tyr Leu Leu Phe Thr Ser Leu Trp Pro Leu Pro Val Leu Tyr
          35                  40                  45            
 Phe Ala Trp Leu Phe Leu Asp Trp Lys Thr Pro Glu Arg Gly Gly Arg
      50                  55                  60                
 Arg Ser Ala Trp Val Arg Asn Trp Cys Val Trp Thr His Ile Arg Asp
  65                  70                  75                  80
 Tyr Phe Pro Ile Thr Ile Leu Lys Thr Lys Asp Leu Ser Pro Glu His
                  85                  90                  95    
 Asn Tyr Leu Met Gly Val His Pro His Gly Leu Leu Thr Phe Gly Ala
             100                 105                 110        
 Phe Cys Asn Phe Cys Thr Glu Ala Thr Gly Phe Ser Lys Thr Phe Pro
         115                 120                 125            
 Gly Ile Thr Pro His Leu Ala Thr Leu Ser Trp Phe Phe Lys Ile Pro
     130                 135                 140                
 Phe Val Arg Glu Tyr Leu Met Ala Lys Gly Val Cys Ser Val Ser Gln
 145                 150                 155                 160
 Pro Ala Ile Asn Tyr Leu Leu Ser His Gly Thr Gly Asn Leu Val Gly
                 165                 170                 175    
 Ile Val Val Gly Gly Val Gly Glu Ala Leu Gln Ser Val Pro Asn Thr
             180                 185                 190        
 Thr Thr Leu Ile Leu Gln Lys Arg Lys Gly Phe Val Arg Thr Ala Leu
         195                 200                 205            
 Gln His Gly Phe Asn Ile Lys Gly Ile Gly Leu Arg Leu Pro Trp His
     210                 215                 220                
 Ile Asp Asp Ala His Ile Ile Ser Ile Asn Ala Gly Ile Tyr Ile Cys
 225                 230                 235                 240
 Leu Leu Met Asp Phe Ile Lys Ile Asp Glu Gly Leu Ala Ser Lys Gln
                 245                 250                 255    
 Met Phe Phe Gln Gly Gly Ser His Pro Ser Leu Cys Leu Glu Asn Lys
             260                 265                 270        
 Leu Glu Phe Ser Tyr Arg Ala His Leu Val Pro Thr Phe Thr Phe Gly
         275                 280                 285            
 Glu Thr Glu Val Tyr Asp Gln Val Leu Phe His Lys Asp Ser Arg Met
     290                 295                 300                
 Tyr Lys Phe Gln Ser Cys Phe Arg Arg Ile Phe Gly Phe Tyr Cys Cys
 305                 310                 315                 320
 Val Phe Tyr Gly Gln Ser Phe Cys Gln Gly Ser Thr Gly Leu Leu Pro
                 325                 330                 335    
 Tyr Ser Arg Pro Ile Val Thr Val Val Gly Glu Pro Leu Pro Leu Pro
             340                 345                 350        
 Gln Ile Glu Lys Pro Ser Gln Glu Met Val Asp Lys Tyr His Ala Leu
         355                 360                 365            
 Tyr Met Asp Ala Leu His Lys Leu Phe Asp Gln His Lys Thr His Tyr
     370                 375                 380                
 Gly Cys Ser Glu Thr Gln Lys Leu Phe Phe Leu
 385                 390                 395



      <210> 1782
      <211> 822
      <212> PRT
      <213> Homo sapiens


      <400> 1782
 Met Ala Val Ala Gly Pro Ala Pro Gly Ala Gly Ala Arg Pro Arg Leu
   1               5                  10                  15    
 Asp Leu Gln Phe Leu Gln Arg Phe Leu Gln Ile Leu Lys Val Leu Phe
              20                  25                  30        
 Pro Ser Trp Ser Ser Gln Asn Ala Leu Met Phe Leu Thr Leu Leu Cys
          35                  40                  45            
 Leu Thr Leu Leu Glu Gln Phe Val Ile Tyr Gln Val Gly Leu Ile Pro
      50                  55                  60                
 Ser Gln Tyr Tyr Gly Val Leu Gly Asn Lys Asp Leu Glu Gly Phe Lys
  65                  70                  75                  80
 Thr Leu Thr Phe Leu Ala Val Met Leu Ile Val Leu Asn Ser Thr Leu
                  85                  90                  95    
 Lys Ser Phe Asp Gln Phe Thr Cys Asn Leu Leu Tyr Val Ser Trp Arg
             100                 105                 110        
 Lys Asp Leu Thr Glu His Leu His Arg Leu Tyr Phe Arg Gly Arg Ala
         115                 120                 125            
 Tyr Tyr Thr Leu Asn Val Leu Arg Asp Asp Ile Asp Asn Pro Asp Gln
     130                 135                 140                
 Arg Ile Ser Gln Asp Val Glu Arg Phe Cys Arg Gln Leu Ser Ser Met
 145                 150                 155                 160
 Ala Ser Lys Leu Ile Ile Ser Pro Phe Thr Leu Val Tyr Tyr Thr Tyr
                 165                 170                 175    
 Gln Cys Phe Gln Ser Thr Gly Trp Leu Gly Pro Val Ser Ile Phe Gly
             180                 185                 190        
 Tyr Phe Ile Leu Gly Thr Val Val Asn Lys Thr Leu Met Gly Pro Ile
         195                 200                 205            
 Val Met Lys Leu Val His Gln Glu Lys Leu Glu Gly Asp Phe Arg Phe
     210                 215                 220                
 Lys His Met Gln Ile Arg Val Asn Ala Glu Pro Ala Ala Phe Tyr Ser
 225                 230                 235                 240
 Val Gly Trp Asn Gly Ser Phe Ser Glu Asn Gln Glu Thr Cys Ser Pro
                 245                 250                 255    
 Gln Cys Cys Leu Met Glu Pro Ser Val Trp Ser Pro Asp Gly Ser Ser
             260                 265                 270        
 Arg Ser Ser Ser Ser Gly Met Lys Ser His Pro Phe Pro Pro Gly Pro
         275                 280                 285            
 Glu Pro Gly Met Trp Met Val Pro Gly Cys Leu Thr Asp Val Phe Ser
     290                 295                 300                
 Thr Val Gly Ile Asn Thr Phe Asp Tyr Leu Gly Ser Ile Leu Ser Tyr
 305                 310                 315                 320
 Val Val Ile Ala Ile Pro Ile Phe Ser Gly Val Tyr Gly Asp Leu Ser
                 325                 330                 335    
 Pro Ala Glu Leu Ser Thr Leu Val Ser Lys Asn Ala Phe Val Cys Ile
             340                 345                 350        
 Tyr Leu Ile Ser Cys Phe Thr Gln Leu Ile Asp Leu Ser Thr Thr Leu
         355                 360                 365            
 Ser Asp Val Ala Gly Tyr Thr His Arg Ile Gly Gln Leu Arg Glu Thr
     370                 375                 380                
 Leu Leu Asp Met Ser Leu Lys Ser Gln Asp Cys Glu Ile Leu Gly Glu
 385                 390                 395                 400
 Ser Glu Trp Gly Leu Asp Thr Pro Pro Gly Trp Pro Ala Ala Glu Pro
                 405                 410                 415    
 Ala Asp Thr Ala Phe Leu Leu Glu Arg Val Ser Ile Ser Ala Pro Ser
             420                 425                 430        
 Ser Asp Lys Pro Leu Ile Lys Asp Leu Ser Leu Lys Ile Ser Glu Gly
         435                 440                 445            
 Gln Ser Leu Leu Ile Thr Gly Asn Thr Gly Thr Gly Lys Thr Ser Leu
     450                 455                 460                
 Leu Arg Val Leu Gly Gly Leu Trp Thr Ser Thr Arg Gly Ser Val Gln
 465                 470                 475                 480
 Met Leu Thr Asp Phe Gly Pro His Gly Val Leu Phe Leu Pro Gln Lys
                 485                 490                 495    
 Pro Phe Phe Thr Asp Gly Thr Leu Arg Glu Gln Val Ile Tyr Pro Leu
             500                 505                 510        
 Lys Glu Val Tyr Pro Asp Ser Gly Ser Ala Asp Asp Glu Arg Ile Leu
         515                 520                 525            
 Arg Phe Leu Glu Leu Ala Gly Leu Ser Asn Leu Val Ala Arg Thr Glu
     530                 535                 540                
 Gly Leu Asp Gln Gln Val Asp Trp Asn Trp Tyr Asp Val Leu Ser Pro
 545                 550                 555                 560
 Gly Glu Met Gln Arg Leu Ser Phe Ala Arg Leu Phe Tyr Leu Gln Pro
                 565                 570                 575    
 Lys Tyr Ala Val Leu Asp Glu Ala Thr Ser Ala Leu Thr Glu Glu Val
             580                 585                 590        
 Glu Ser Glu Leu Tyr Arg Ile Gly Gln Gln Leu Gly Met Thr Phe Ile
         595                 600                 605            
 Ser Val Gly His Arg Gln Ser Leu Glu Lys Val Ser Glu Leu Ser Ser
     610                 615                 620                
 Ser Gly Ala Gly Ser Arg Ala Gly Ala Arg Ala Gly Ala Gly Ser Ser
 625                 630                 635                 640
 Phe Lys Ala Ala Ile Gly Ala Asp Ser Ser Ser Arg Ala Asp Thr Lys
                 645                 650                 655    
 Ala Glu Tyr Ser Ser Val Ala Gly Thr Thr Thr Gly Leu Ser Ser Gly
             660                 665                 670        
 Thr Gly Asp Gly Ala Ser Ser Arg Ala Ser Thr Gly Phe Ser Ser Gly
         675                 680                 685            
 Gly Gly Ala Lys Ala Gly Thr Ser Pro Gly Leu Gly Ser Gly Ala Gly
     690                 695                 700                
 Ala Arg Ala Gly Ser Ser Phe Ser Ser Gly Ala Gly Ala Ser Asp Gly
 705                 710                 715                 720
 Ala Gly Ser Ser Cys Ala Ala Gly Ala Gly Ala Gly Thr Ser Ser Gly
                 725                 730                 735    
 Pro Arg Thr Ser Phe Ser Ala Ser Val Gly Ala Glu Pro Ala Ser Gly
             740                 745                 750        
 Ser Gly Ala Gly Thr Lys Ser Gly Tyr Ser Ser Arg Val Asp Ala Arg
         755                 760                 765            
 Val Gly Ala Gly Val Gly Ala Glu Leu Ser Val Ala Leu Glu Leu Glu
     770                 775                 780                
 Leu Val Leu Leu Val Leu Lys Leu Met Val Glu Leu Thr Pro Asp Leu
 785                 790                 795                 800
 Ala Leu Ala Leu Asp Leu Val Ser Glu Leu Ala Leu Glu Leu Glu Glu
                 805                 810                 815    
 Glu Lys Gly Leu Pro Ala
             820        



      <210> 1783
      <211> 803
      <212> PRT
      <213> Homo sapiens


      <400> 1783
 Met Val Ala Met Gly Met Pro Gln Leu Leu Gln Arg Trp Leu Leu Val
   1               5                  10                  15    
 Pro Glu Ala Gly Met Ala Glu Thr Ala Asn His Arg Thr Glu Ala Gly
              20                  25                  30        
 Gly Gly Glu Arg Gly His Gln Gly His Asn Val Ser Gly Glu Ile Ala
          35                  40                  45            
 Gly Arg Lys Tyr Ala Glu Lys Ala Arg Ile Pro Gly Glu Phe Gln Gly
      50                  55                  60                
 Asp Tyr Arg Gln Ala Leu Glu Ile Cys Gly Leu Lys Gly Ala Gly Ser
  65                  70                  75                  80
 Arg Ala Cys Glu Cys Gly Pro Arg His Gln Ser Pro Asn Pro Pro Pro
                  85                  90                  95    
 Pro Trp Phe Gly Cys Glu Asp Thr Gly Pro Pro Ser Leu Phe Ser Val
             100                 105                 110        
 Gly Arg His Pro Val Leu Ser Leu Glu Leu Leu Leu Asp Ala Thr Ala
         115                 120                 125            
 Ser Ala Pro Trp Val Thr Leu Leu Pro Val Gln Arg Ser Phe Phe Leu
     130                 135                 140                
 Pro Pro Phe Ser Gly Ala Thr Pro Ser Thr Ser Leu Ala Glu Ser Val
 145                 150                 155                 160
 Leu Lys Val Trp His Gly Ala Tyr Asn Ser Gly Leu Leu Pro Gln Leu
                 165                 170                 175    
 Met Ala Gln His Ser Leu Ala Met Ala Gln Asn Gly Ala Val Pro Ser
             180                 185                 190        
 Glu Ala Thr Lys Arg Asp Gln Asn Leu Lys Arg Gly Asn Trp Gly Asn
         195                 200                 205            
 Gln Ile Glu Phe Val Leu Thr Ser Val Gly Tyr Ala Val Gly Leu Gly
     210                 215                 220                
 Asn Val Trp Arg Phe Pro Tyr Leu Cys Tyr Arg Asn Gly Gly Gly Ala
 225                 230                 235                 240
 Phe Met Phe Pro Tyr Phe Ile Met Leu Ile Phe Cys Gly Ile Pro Leu
                 245                 250                 255    
 Phe Phe Met Glu Leu Ser Phe Gly Gln Phe Ala Ser Gln Gly Cys Leu
             260                 265                 270        
 Gly Val Trp Arg Ile Ser Pro Met Phe Lys Gly Val Gly Tyr Gly Met
         275                 280                 285            
 Met Val Val Ser Thr Tyr Ile Gly Ile Tyr Tyr Asn Val Val Ile Cys
     290                 295                 300                
 Ile Ala Phe Tyr Tyr Phe Phe Ser Ser Met Thr His Val Leu Pro Trp
 305                 310                 315                 320
 Ala Tyr Cys Asn Asn Pro Trp Asn Thr His Asp Cys Ala Gly Val Leu
                 325                 330                 335    
 Asp Ala Ser Asn Leu Thr Asn Gly Ser Arg Pro Ala Ala Leu Pro Ser
             340                 345                 350        
 Asn Leu Ser His Leu Leu Asn His Ser Leu Gln Arg Thr Ser Pro Ser
         355                 360                 365            
 Glu Glu Tyr Trp Arg Leu Tyr Val Leu Lys Leu Ser Asp Asp Ile Gly
     370                 375                 380                
 Asn Phe Gly Glu Val Arg Leu Pro Leu Leu Gly Cys Leu Gly Val Ser
 385                 390                 395                 400
 Trp Leu Val Val Phe Leu Cys Leu Ile Arg Gly Val Val Tyr Phe Thr
                 405                 410                 415    
 Ala Thr Phe Pro Tyr Val Val Leu Thr Ile Leu Phe Val Arg Gly Val
             420                 425                 430        
 Thr Leu Glu Gly Ala Phe Asp Gly Ile Met Tyr Tyr Leu Thr Pro Gln
         435                 440                 445            
 Trp Asp Lys Ile Leu Glu Ala Lys Val Trp Gly Asp Ala Ala Ser Gln
     450                 455                 460                
 Ile Phe Tyr Ser Leu Gly Cys Ala Trp Gly Gly Leu Ile Thr Met Ala
 465                 470                 475                 480
 Ser Tyr Asn Lys Phe His Asn Asn Cys Tyr Arg Asp Ser Val Ile Ile
                 485                 490                 495    
 Ser Ile Thr Asn Cys Ala Thr Ser Val Tyr Ala Gly Phe Val Ile Phe
             500                 505                 510        
 Ser Ile Leu Gly Phe Met Ala Asn His Leu Gly Val Asp Val Ser Arg
         515                 520                 525            
 Val Ala Asp His Gly Pro Gly Leu Ala Phe Val Ala Tyr Pro Glu Ala
     530                 535                 540                
 Leu Thr Leu Leu Pro Ile Ser Pro Leu Trp Ser Leu Leu Phe Phe Phe
 545                 550                 555                 560
 Met Leu Ile Leu Leu Gly Leu Gly Thr Gln Phe Cys Leu Leu Glu Thr
                 565                 570                 575    
 Leu Val Thr Ala Ile Val Asp Glu Val Gly Asn Glu Trp Ile Leu Gln
             580                 585                 590        
 Lys Lys Thr Tyr Val Thr Leu Gly Val Ala Val Ala Gly Phe Leu Leu
         595                 600                 605            
 Gly Ile Pro Leu Thr Ser Gln Ala Gly Ile Tyr Trp Leu Leu Leu Met
     610                 615                 620                
 Asp Asn Tyr Ala Ala Ser Phe Ser Leu Val Val Ile Ser Cys Ile Met
 625                 630                 635                 640
 Cys Val Ala Ile Met Tyr Ile Tyr Gly His Arg Asn Tyr Phe Gln Asp
                 645                 650                 655    
 Ile Gln Met Met Leu Gly Phe Pro Pro Pro Leu Phe Phe Gln Ile Cys
             660                 665                 670        
 Trp Arg Phe Val Ser Pro Ala Ile Ile Phe Phe Ile Leu Val Phe Thr
         675                 680                 685            
 Val Ile Gln Tyr Gln Pro Ile Thr Tyr Asn His Tyr Gln Tyr Pro Gly
     690                 695                 700                
 Trp Ala Val Ala Ile Gly Phe Leu Met Ala Leu Ser Ser Val Leu Cys
 705                 710                 715                 720
 Ile Pro Leu Tyr Ala Met Phe Arg Leu Cys Arg Thr Asp Gly Asp Thr
                 725                 730                 735    
 Leu Leu Gln Arg Leu Lys Asn Ala Thr Lys Pro Ser Arg Asp Trp Gly
             740                 745                 750        
 Pro Ala Leu Leu Glu His Arg Thr Gly Arg Tyr Ala Pro Thr Ile Ala
         755                 760                 765            
 Pro Ser Pro Glu Asp Gly Phe Glu Val Gln Pro Leu His Pro Asp Lys
     770                 775                 780                
 Ala Gln Ile Pro Ile Val Gly Ser Asn Gly Ser Ser Arg Leu Gln Asp
 785                 790                 795                 800
 Ser Arg Ile
            



      <210> 1784
      <211> 2269
      <212> PRT
      <213> Homo sapiens


      <400> 1784
 Met Ala Pro Arg Ala Ala Gly Gly Ala Pro Leu Ser Ala Trp Ala Ala
   1               5                  10                  15    
 Ala Ala Ser Pro Pro Pro Phe Gln Thr Pro Pro Arg Cys Pro Val Pro
              20                  25                  30        
 Leu Leu Leu Leu Leu Leu Leu Gly Ala Ala Arg Ala Gly Ala Leu Glu
          35                  40                  45            
 Ile Gln Arg Arg Phe Pro Ser Pro Thr Pro Thr Asn Asn Phe Ala Leu
      50                  55                  60                
 Asp Gly Ala Ala Gly Thr Val Tyr Leu Ala Ala Ala Asn Arg Leu Tyr
  65                  70                  75                  80
 Gln Leu Ser Gly Ala Asn Leu Ser Leu Glu Ala Glu Ala Ala Val Gly
                  85                  90                  95    
 Pro Val Pro Asp Ser Pro Leu Cys His Ala Ser Gln Leu Pro Gln Ala
             100                 105                 110        
 Ser Cys Glu His Pro Arg Arg Leu Thr Asp Asn Tyr Asn Lys Ile Leu
         115                 120                 125            
 Gln Leu Asp Pro Gly Gln Gly Leu Val Val Val Cys Gly Ser Ile Tyr
     130                 135                 140                
 Gln Gly Phe Cys Gln Leu Arg Arg Arg Gly Asn Ile Ser Ala Val Ala
 145                 150                 155                 160
 Val Arg Phe Pro Pro Ala Ala Pro Pro Ala Glu Pro Val Thr Val Phe
                 165                 170                 175    
 Pro Ser Met Leu Asn Val Ala Ala Asn His Pro Asn Ala Ser Thr Val
             180                 185                 190        
 Gly Leu Val Leu Pro Pro Ala Ala Gly Ala Gly Gly Ser Arg Leu Leu
         195                 200                 205            
 Val Gly Ala Thr Tyr Thr Gly Tyr Gly Ser Ser Phe Phe Pro Arg Asn
     210                 215                 220                
 Arg Ser Leu Glu Asp His Arg Phe Glu Asn Thr Pro Glu Ile Ala Ile
 225                 230                 235                 240
 Arg Ser Leu Asp Thr Arg Gly Asp Leu Ala Lys Leu Phe Thr Phe Asp
                 245                 250                 255    
 Leu Asn Pro Ser Asp Asp Asn Ile Leu Lys Ile Lys Gln Gly Ala Lys
             260                 265                 270        
 Glu Gln His Lys Leu Gly Phe Val Ser Ala Phe Leu His Pro Ser Asp
         275                 280                 285            
 Pro Pro Pro Gly Ala Gln Ser Tyr Ala Tyr Leu Ala Leu Asn Ser Glu
     290                 295                 300                
 Ala Arg Ala Gly Asp Lys Glu Ser Gln Ala Arg Ser Leu Leu Ala Arg
 305                 310                 315                 320
 Ile Cys Leu Pro His Gly Ala Gly Gly Asp Ala Lys Lys Leu Thr Glu
                 325                 330                 335    
 Ser Tyr Ile Gln Leu Gly Leu Gln Cys Ala Gly Gly Ala Gly Arg Gly
             340                 345                 350        
 Asp Leu Tyr Ser Arg Leu Val Ser Val Phe Pro Ala Arg Glu Arg Leu
         355                 360                 365            
 Phe Ala Val Phe Glu Arg Pro Gln Gly Ser Pro Ala Ala Arg Ala Ala
     370                 375                 380                
 Pro Ala Ala Leu Cys Ala Phe Arg Phe Ala Asp Val Arg Ala Ala Ile
 385                 390                 395                 400
 Arg Ala Ala Arg Thr Ala Cys Phe Val Glu Pro Ala Pro Asp Val Val
                 405                 410                 415    
 Ala Val Leu Asp Ser Val Val Gln Gly Thr Gly Pro Ala Cys Glu Arg
             420                 425                 430        
 Lys Leu Asn Ile Gln Val Glu Val Gly Leu Pro Arg Leu Pro Thr Ile
         435                 440                 445            
 Trp Pro Ala Thr Leu Lys Val Lys Val Thr Ser Thr Gly Ser Met Leu
     450                 455                 460                
 Glu Asn Val Met His Val Leu Pro Trp Glu Met Cys Asp Gln His Ser
 465                 470                 475                 480
 Ala Ile Thr Gly Val Gly Gly Leu Ser His Ile Leu Lys Thr Cys Arg
                 485                 490                 495    
 Leu Gly Met Pro Gly Glu Gly Thr Ala Trp Val Gln Thr Pro Gly Ala
             500                 505                 510        
 Leu Lys Cys Gln Gly Glu Tyr Glu Cys Leu Arg Gly Met Gly Trp Ala
         515                 520                 525            
 Leu Ala Ala Glu Gly Thr Phe Thr Met Val Gln Glu Pro Arg Leu Gln
     530                 535                 540                
 Pro Glu Gln Leu Asp Cys Gly Ala Ala His Leu Gln His Pro Leu Ser
 545                 550                 555                 560
 Ile Leu Gln Pro Leu Lys Ala Thr Pro Val Phe Arg Ala Pro Gly Leu
                 565                 570                 575    
 Thr Ser Val Ala Val Ala Ser Val Asn Asn Tyr Thr Ala Val Phe Leu
             580                 585                 590        
 Gly Thr Val Asn Gly Arg Leu Leu Lys Ile Asn Leu Asn Glu Ser Met
         595                 600                 605            
 Gln Val Val Ser Arg Arg Val Val Thr Val Ala Tyr Gly Glu Pro Val
     610                 615                 620                
 His His Val Met Gln Phe Asp Pro Ala Asp Ser Gly Tyr Leu Tyr Leu
 625                 630                 635                 640
 Met Thr Ser His Gln Met Ala Arg Val Lys Val Ala Ala Cys Asn Val
                 645                 650                 655    
 His Ser Thr Cys Gly Asp Cys Val Gly Ala Ala Asp Ala Tyr Cys Gly
             660                 665                 670        
 Trp Cys Ala Leu Glu Thr Arg Cys Thr Leu Gln Gln Asp Cys Thr Asn
         675                 680                 685            
 Ser Ser Gln Gln His Phe Trp Thr Ser Ala Ser Glu Gly Pro Ser Arg
     690                 695                 700                
 Cys Pro Ala Met Thr Val Leu Pro Ser Glu Ile Asp Val Arg Gln Glu
 705                 710                 715                 720
 Tyr Pro Gly Met Ile Leu Gln Ile Ser Gly Ser Leu Pro Ser Leu Ser
                 725                 730                 735    
 Gly Met Glu Met Ala Cys Asp Tyr Gly Asn Asn Ile Arg Thr Val Ala
             740                 745                 750        
 Arg Val Pro Gly Pro Ala Phe Gly His Gln Ile Ala Tyr Cys Asn Leu
         755                 760                 765            
 Leu Pro Arg Asp Gln Phe Pro Pro Phe Pro Pro Asn Gln Asp His Val
     770                 775                 780                
 Thr Val Glu Met Ser Val Arg Val Asn Gly Arg Asn Ile Val Lys Ala
 785                 790                 795                 800
 Asn Phe Thr Ile Tyr Asp Cys Ser Arg Thr Ala Gln Val Tyr Pro His
                 805                 810                 815    
 Thr Ala Cys Thr Ser Cys Leu Ser Ala Gln Trp Pro Cys Phe Trp Cys
             820                 825                 830        
 Ser Gln Gln His Ser Cys Val Ser Asn Gln Ser Arg Cys Glu Ala Ser
         835                 840                 845            
 Pro Asn Pro Thr Ser Pro Gln Asp Cys Pro Arg Thr Leu Leu Ser Pro
     850                 855                 860                
 Leu Ala Pro Val Pro Thr Gly Gly Ser Gln Asn Ile Leu Val Pro Leu
 865                 870                 875                 880
 Ala Asn Thr Ala Phe Phe Gln Gly Ala Ala Leu Glu Cys Ser Phe Gly
                 885                 890                 895    
 Leu Glu Glu Ile Phe Glu Ala Val Trp Val Asn Glu Ser Val Val Arg
             900                 905                 910        
 Cys Asp Gln Val Val Leu His Thr Thr Arg Lys Ser Gln Val Phe Pro
         915                 920                 925            
 Leu Ser Leu Gln Leu Lys Gly Arg Pro Ala Arg Phe Leu Asp Ser Pro
     930                 935                 940                
 Glu Pro Met Thr Val Met Val Tyr Asn Cys Ala Met Gly Ser Pro Asp
 945                 950                 955                 960
 Cys Ser Gln Cys Leu Gly Arg Glu Asp Leu Gly His Leu Cys Met Trp
                 965                 970                 975    
 Ser Asp Gly Cys Arg Leu Arg Gly Pro Leu Gln Pro Met Ala Gly Thr
             980                 985                 990        
 Cys Pro Ala Pro Glu Ile His Ala Trp Val Cys Thr Ala Val Pro Cys
         995                1000                1005            
 Trp Val Pro Val Thr Val Gly Arg Ser Leu Leu Ala Cys Ser Leu Arg
    1010                1015                1020                
 Ser His Ser Pro Leu Ser Arg Val Thr Trp Gln Ile Glu Pro Leu Ser
1025                1030                1035                1040
 Gly Pro Leu Asp Gly Gly Thr Leu Leu Thr Ile Arg Gly Arg Asn Leu
                1045                1050                1055    
 Gly Arg Arg Leu Ser Asp Val Ala His Gly Val Trp Ile Gly Gly Val
            1060                1065                1070        
 Ala Cys Glu Pro Leu Pro Asp Arg Tyr Thr Val Ser Glu Glu Ile Val
        1075                1080                1085            
 Cys Val Thr Gly Pro Ala Pro Gly Pro Leu Ser Gly Val Val Thr Val
    1090                1095                1100                
 Asn Ala Ser Lys Glu Gly Lys Ser Arg Asp Arg Phe Ser Tyr Val Leu
1105                1110                1115                1120
 Pro Leu Val His Ser Leu Glu Pro Thr Met Gly Pro Lys Ala Gly Gly
                1125                1130                1135    
 Thr Arg Ile Thr Ile His Gly Asn Asp Leu His Val Gly Ser Glu Leu
            1140                1145                1150        
 Gln Val Leu Val Asn Asp Thr Asp Pro Cys Thr Glu Leu Met Arg Thr
        1155                1160                1165            
 Asp Thr Ser Ile Ala Cys Thr Met Pro Glu Gly Ala Leu Pro Ala Pro
    1170                1175                1180                
 Val Pro Val Cys Val Arg Phe Glu Arg Arg Gly Cys Val His Gly Asn
1185                1190                1195                1200
 Leu Thr Phe Trp Tyr Met Gln Asn Pro Val Ile Thr Ala Ile Ser Pro
                1205                1210                1215    
 Arg Arg Ser Pro Val Arg Leu Ser Gly Ala Ala Gly Ala Leu Ile Gly
            1220                1225                1230        
 Phe Ala Val Pro Arg Ser Gly Gly Arg Thr Ile Thr Val Ala Gly Glu
        1235                1240                1245            
 Arg Phe His Met Val Gln Asn Val Ser Met Ala Val His His Ile Gly
    1250                1255                1260                
 Arg Glu Pro Thr Leu Cys Lys Val Leu Asn Ser Thr Leu Ile Thr Cys
1265                1270                1275                1280
 Pro Ser Pro Gly Ala Leu Ser Asn Ala Ser Ala Pro Val Asp Phe Phe
                1285                1290                1295    
 Ile Asn Gly Arg Ala Tyr Ala Asp Glu Val Ala Val Ala Glu Glu Leu
            1300                1305                1310        
 Leu Asp Pro Glu Glu Ala Gln Arg Gly Ser Arg Phe Arg Leu Asp Tyr
        1315                1320                1325            
 Leu Pro Asn Pro Gln Phe Ser Thr Ala Lys Arg Glu Lys Trp Ile Lys
    1330                1335                1340                
 His His Pro Gly Glu Pro Leu Thr Leu Val Ile His Val Ser Thr Lys
1345                1350                1355                1360
 Gly Ala Gly Lys Glu Gln Asp Ser Leu Gly Leu Gln Ser His Glu Tyr
                1365                1370                1375    
 Arg Val Lys Ile Gly Gln Val Ser Cys Asp Ile Gln Ile Val Ser Asp
            1380                1385                1390        
 Arg Ile Ile His Cys Ser Val Asn Glu Ser Leu Gly Ala Ala Val Gly
        1395                1400                1405            
 Gln Leu Pro Ile Thr Ile Gln Val Gly Asn Phe Asn Gln Thr Ile Ala
    1410                1415                1420                
 Thr Leu Gln Leu Gly Gly Ser Glu Thr Ala Ile Ile Val Ser Ile Val
1425                1430                1435                1440
 Ile Cys Ser Val Leu Leu Leu Leu Ser Val Val Ala Leu Phe Val Phe
                1445                1450                1455    
 Cys Thr Lys Ser Arg Arg Ala Glu Arg Tyr Trp Gln Lys Thr Leu Leu
            1460                1465                1470        
 Gln Met Glu Glu Met Glu Ser Gln Ile Arg Glu Glu Ile Arg Lys Gly
        1475                1480                1485            
 Asp Gly Phe Ser Gly Arg Ser Arg Leu Ser Val Cys Pro Pro Gly Phe
    1490                1495                1500                
 Ala Glu Leu Gln Thr Asp Met Thr Asp Leu Thr Lys Glu Leu Asn Arg
1505                1510                1515                1520
 Ser Gln Gly Ile Pro Phe Leu Glu Tyr Lys His Phe Val Thr Arg Thr
                1525                1530                1535    
 Phe Phe Pro Lys Cys Ser Ser Leu Tyr Glu Glu Arg Tyr Val Leu Pro
            1540                1545                1550        
 Ser Gln Thr Leu Asn Ser Gln Gly Ser Ser Gln Ala Gln Glu Thr His
        1555                1560                1565            
 Pro Leu Leu Gly Glu Trp Lys Ile Pro Glu Ser Cys Arg Pro Asn Met
    1570                1575                1580                
 Glu Glu Gly Ile Ser Leu Phe Ser Ser Leu Leu Asn Asn Lys His Phe
1585                1590                1595                1600
 Leu Ile Val Phe Val His Ala Leu Glu Gln Gln Lys Asp Phe Ala Val
                1605                1610                1615    
 Arg Asp Arg Cys Ser Leu Ala Ser Leu Leu Thr Ile Ala Leu His Gly
            1620                1625                1630        
 Lys Leu Glu Tyr Tyr Thr Ser Ile Met Lys Glu Leu Leu Val Asp Leu
        1635                1640                1645            
 Ile Asp Ala Ser Ala Ala Lys Asn Pro Lys Leu Met Leu Arg Arg Thr
    1650                1655                1660                
 Glu Ser Val Val Glu Lys Met Leu Thr Asn Trp Met Ser Ile Cys Met
1665                1670                1675                1680
 Tyr Ser Cys Leu Arg Glu Thr Val Gly Glu Pro Phe Phe Leu Leu Leu
                1685                1690                1695    
 Cys Ala Ile Lys Gln Gln Ile Asn Lys Gly Ser Ile Asp Ala Ile Thr
            1700                1705                1710        
 Gly Lys Ala Arg Tyr Thr Leu Asn Glu Glu Trp Leu Leu Arg Glu Asn
        1715                1720                1725            
 Ile Glu Ala Lys Pro Arg Asn Leu Asn Val Ser Phe Gln Gly Cys Gly
    1730                1735                1740                
 Met Asp Ser Leu Ser Val Arg Ala Met Asp Thr Asp Thr Leu Thr Gln
1745                1750                1755                1760
 Val Lys Glu Lys Ile Leu Glu Ala Phe Cys Lys Asn Val Pro Tyr Ser
                1765                1770                1775    
 Gln Trp Pro Arg Ala Glu Asp Val Asp Leu Glu Trp Phe Ala Ser Ser
            1780                1785                1790        
 Thr Gln Ser Tyr Ile Leu Arg Asp Leu Asp Asp Thr Ser Val Val Glu
        1795                1800                1805            
 Asp Gly Arg Lys Lys Leu Asn Thr Leu Ala His Tyr Lys Ile Pro Glu
    1810                1815                1820                
 Gly Ala Ser Leu Ala Met Ser Leu Ile Asp Lys Lys Asp Asn Thr Leu
1825                1830                1835                1840
 Gly Arg Val Lys Asp Leu Asp Thr Glu Lys Tyr Phe His Leu Val Leu
                1845                1850                1855    
 Pro Thr Asp Glu Leu Ala Glu Pro Lys Lys Ser His Arg Gln Ser His
            1860                1865                1870        
 Arg Lys Lys Val Leu Pro Glu Ile Tyr Leu Thr Arg Leu Leu Ser Thr
        1875                1880                1885            
 Lys Gly Thr Leu Gln Lys Phe Leu Asp Asp Leu Phe Lys Ala Ile Leu
    1890                1895                1900                
 Ser Ile Arg Glu Asp Lys Pro Pro Leu Ala Val Lys Tyr Phe Phe Asp
1905                1910                1915                1920
 Phe Leu Glu Glu Gln Ala Glu Lys Arg Gly Ile Ser Asp Pro Asp Thr
                1925                1930                1935    
 Leu His Ile Trp Lys Thr Asn Ser Leu Pro Leu Arg Phe Trp Val Asn
            1940                1945                1950        
 Ile Leu Lys Asn Pro Gln Phe Val Phe Asp Ile Asp Lys Thr Asp His
        1955                1960                1965            
 Ile Asp Ala Cys Leu Ser Val Ile Ala Gln Ala Phe Ile Asp Ala Cys
    1970                1975                1980                
 Ser Ile Ser Asp Leu Gln Leu Gly Lys Asp Ser Pro Thr Asn Lys Leu
1985                1990                1995                2000
 Leu Tyr Ala Lys Glu Ile Pro Glu Tyr Arg Lys Ile Val Gln Arg Tyr
                2005                2010                2015    
 Tyr Lys Gln Ile Gln Asp Met Thr Pro Leu Ser Glu Gln Glu Met Asn
            2020                2025                2030        
 Ala His Leu Ala Glu Glu Ser Arg Val Arg Trp Leu Gly Gly Gly Gly
        2035                2040                2045            
 Trp Gly Pro Glu Glu Leu Arg Asp Arg Gly Ser Gly Ala Gly Pro Gln
    2050                2055                2060                
 Cys Leu His Trp Ser Lys Gly Arg Glu Arg Arg Gly His Phe Arg Ser
2065                2070                2075                2080
 Gly Cys Gly Leu Leu Leu Ala Cys Lys Phe Val Met His Phe Pro Arg
                2085                2090                2095    
 Lys Tyr Gln Asn Glu Phe Asn Thr Asn Val Ala Met Ala Glu Ile Tyr
            2100                2105                2110        
 Lys Tyr Ala Lys Arg Tyr Arg Pro Gln Ile Met Ala Ala Leu Glu Ala
        2115                2120                2125            
 Asn Pro Thr Ala Arg Arg Thr Gln Leu Gln His Lys Phe Glu Gln Val
    2130                2135                2140                
 Val Ala Leu Met Glu Asp Asn Ile Tyr Glu Cys Tyr Arg Lys Asp Leu
2145                2150                2155                2160
 Glu Ser Gln Leu Gln Arg Gly Ala Tyr Phe Glu Ala Ala Ser Gly Pro
                2165                2170                2175    
 Pro Gly Phe Gly Val Glu Gly Pro Gly Glu Glu Ala Thr Ala His Ala
            2180                2185                2190        
 Ser Gly Gln Arg Leu Leu Gln Gln Lys Val Arg Gly Pro Ser Ser Gly
        2195                2200                2205            
 Leu Cys Gln Ala Pro Ala Leu Leu Leu Glu Ser Leu Lys Arg Ser Glu
    2210                2215                2220                
 Ser Gln Leu Cys Phe Arg Val Ser Ser Leu Cys Ala Leu Val Glu Glu
2225                2230                2235                2240
 Gln Gly Cys Ile Cys Leu Val Pro Gly Gly Ile Pro Gly Ala Gln His
                2245                2250                2255    
 Ser Thr Trp His Thr Val Gly Ala Gln Tyr Pro Leu Leu
            2260                2265                



      <210> 1785
      <211> 872
      <212> PRT
      <213> Homo sapiens


      <400> 1785
 Met Ala Trp Leu Pro Ala Tyr Ala Thr Cys Gln Met Phe Ala His Leu
   1               5                  10                  15    
 Thr Gln Glu Pro Cys Ser Val Ala Lys Gln Pro Trp Ser Leu Thr Leu
              20                  25                  30        
 Pro Gly Pro Thr Phe Cys Ala Pro Glu Cys Gly Cys Gln Ser Pro Asp
          35                  40                  45            
 Val Ser Ala Leu Pro Ser Pro Thr Ser Thr Leu Pro Ala Ala Ser Trp
      50                  55                  60                
 Pro Gly Ser Ala Met Gly Leu Ala Ala Ala Ser Cys Ser Ser Ser Tyr
  65                  70                  75                  80
 Pro Asn Thr Pro Ala Trp Asn Met Arg Gln Cys Val Cys Ile Ser Val
                  85                  90                  95    
 His Leu Tyr Val Ser Cys Thr Gly Val Ser Ser Cys Ile Ser Val Cys
             100                 105                 110        
 Val Tyr Val Thr Pro Ala Leu Val Tyr Val Tyr Thr Arg Phe Leu Val
         115                 120                 125            
 Val Cys Leu Asp Thr Met Gly Leu Cys Val Cys Ala Leu Cys Ala Leu
     130                 135                 140                
 Val Ser Glu Cys Ala Leu Cys Ser Lys Ala Glu Arg Val Ala Arg Arg
 145                 150                 155                 160
 Ser Gly Arg Asp Met Cys Gly Gly Val Arg Val Pro Leu Arg Val Ser
                 165                 170                 175    
 Val Cys Leu Arg Trp Asn Ala Gly Gln His Val Ser Gly Arg Pro Arg
             180                 185                 190        
 Arg Pro Thr Thr Ile Asp Glu Pro Thr Asp Leu Arg Thr Gln Glu Thr
         195                 200                 205            
 Asp Asp Leu Cys Ser His Cys His Thr His Pro Leu Thr His Thr His
     210                 215                 220                
 Leu Leu Lys Trp Asp Thr Tyr Ile Gly Val Gly Leu Ala Thr Gln Gln
 225                 230                 235                 240
 Tyr Leu Phe Asp Ala Arg Met Asp Thr Gly Asn Cys Gly Leu Val Phe
                 245                 250                 255    
 Thr Thr Thr Pro Ser Ala His Ile Asn Thr His Lys Pro Leu Glu Met
             260                 265                 270        
 Ile Gln Ile Ala Thr Lys Ala His Gly Asp His Asp Thr Ser Gln Thr
         275                 280                 285            
 His Gly Ala Leu Ser Thr Cys Leu Asp Thr Gly Pro Asn Ile Leu Ser
     290                 295                 300                
 His Thr Leu Leu Gly Thr Gln Pro Glu Leu Lys Cys Trp Gly Cys Ser
 305                 310                 315                 320
 Arg Glu Pro Val His Ser Phe Asp Lys Tyr Leu Pro Ser Thr Ser Trp
                 325                 330                 335    
 Val Pro Gly Ser Val Leu Gly Pro Gly Gly Ser Ala Gly Ser Lys Ile
             340                 345                 350        
 Cys Lys Asp Ala Ser Pro Gly Ala Asn Leu Thr Ser Lys Pro Ala Ala
         355                 360                 365            
 Ile Val Gly Ser Leu Ala Phe Ser Ala Ala Trp Gly Trp Asp Leu Glu
     370                 375                 380                
 Met Gly Ile Trp Gly Trp Gly Pro Gly Leu Trp Thr Ser Gly Ala Phe
 385                 390                 395                 400
 Cys Val Leu Gly Cys Ile Pro Lys Gly Glu Ser Leu Lys Val Gly Ser
                 405                 410                 415    
 Glu His Arg Ala Trp Tyr Thr Ser Asn Ala Pro Val Ser Ala Gly Ile
             420                 425                 430        
 Ser Ala Ser Pro Asp Pro Ile Asn Leu Val Ser Ala Gly Pro Ala Gln
         435                 440                 445            
 Ala Trp Ser Ser Gly Lys Thr Trp Glu Thr Gly Ile Gly Trp Ser Pro
     450                 455                 460                
 Thr Glu Ser Asp Gly Lys Ala Lys Ala Gln Glu Glu Thr Gly Arg Arg
 465                 470                 475                 480
 Lys Gly Gly Lys Arg Arg Phe Glu Ala Pro Asp Val Arg Arg Asp Leu
                 485                 490                 495    
 Cys Gly Met Tyr Gln Ala Gly Ser Asp Asp Gly Thr Ala Met Gly Ala
             500                 505                 510        
 Glu Trp Arg Val Gly Thr Ala Asp Pro Gly Gly Ser Phe Leu Leu Cys
         515                 520                 525            
 Val Leu Asn Arg Val Ile Glu Gly Asp Phe Pro Cys Lys Gln Phe Val
     530                 535                 540                
 Leu Glu Leu Lys Asp Ala Glu Gly Glu Arg Gly Ile Ser Ser Arg Ala
 545                 550                 555                 560
 Pro Ser Leu Ala Ala Gln Cys Cys Arg Cys Val Met Ser Ala Val Pro
                 565                 570                 575    
 Phe Pro Ser Leu Ala Ala Val Trp Pro Leu Ser Ser Cys Gly Leu Pro
             580                 585                 590        
 Arg Ser Ser Ser Asn Leu Gly Thr Arg Cys Phe Thr Ile Gly Leu Lys
         595                 600                 605            
 His Gly Cys Ser Ile Ala Leu Thr Gly Glu Thr Pro Ser Glu Val Gly
     610                 615                 620                
 Leu Pro Tyr Pro Val Leu Thr Leu Ser Ala Cys Cys Glu Glu Gly Pro
 625                 630                 635                 640
 Gln Val Glu Asp Gln Ser Arg Gly Ser Pro Asp Glu Phe His Pro Phe
                 645                 650                 655    
 Ile Glu Ala Leu Leu Pro His Val Arg Ala Phe Ser Tyr Thr Trp Phe
             660                 665                 670        
 Asn Leu Gln Ala Arg Lys Arg Lys Tyr Phe Lys Lys His Glu Lys Arg
         675                 680                 685            
 Met Ser Lys Asp Glu Glu Arg Ala Val Lys Asp Glu Leu Leu Gly Glu
     690                 695                 700                
 Lys Pro Glu Ile Lys Gln Lys Trp Ala Ser Arg Leu Leu Ala Lys Leu
 705                 710                 715                 720
 Arg Lys Asp Ile Arg Pro Glu Phe Arg Glu Asp Phe Val Leu Thr Ile
                 725                 730                 735    
 Thr Gly Lys Lys Pro Pro Cys Cys Val Leu Ser Asn Pro Asp Gln Lys
             740                 745                 750        
 Gly Lys Ile Arg Arg Ile Asp Cys Leu Arg Gln Ala Asp Lys Val Trp
         755                 760                 765            
 Arg Leu Asp Leu Val Met Val Ile Leu Phe Lys Gly Ile Pro Leu Glu
     770                 775                 780                
 Ser Thr Asp Gly Glu Arg Leu Tyr Lys Ser Pro Gln Cys Ser Asn Pro
 785                 790                 795                 800
 Gly Leu Cys Val Gln Pro His His Ile Gly Val Thr Ile Lys Glu Leu
                 805                 810                 815    
 Asp Leu Tyr Leu Ala Tyr Phe Val His Thr Pro Ala Ser Gln Ile Trp
             820                 825                 830        
 Glu Gly Val Cys Leu Val Val Leu Glu Val Thr Gly Gly Leu Gln Lys
         835                 840                 845            
 Ala Arg Ser Leu Glu Leu Thr Ser Val Ala Ile Arg Tyr Ser Cys Thr
     850                 855                 860                
 Arg Gly Phe Cys Thr Phe Gln Phe
 865                 870        



      <210> 1786
      <211> 954
      <212> PRT
      <213> Homo sapiens


      <400> 1786
 Met Asn Gly Leu Pro Val Pro Gly Arg Gly Val His Phe Ala Leu Thr
   1               5                  10                  15    
 Phe Ala Arg Thr Leu Ala Ser Trp Phe Ser Asp Met Gly Met His Gln
              20                  25                  30        
 Asn Asp Pro Asp Ala Leu Lys Thr Leu Pro Gly Pro Ser Pro Arg Ala
          35                  40                  45            
 Ser Asp Ser Ala Gly Leu Gly Thr Gln His Asn Thr Trp Asn Ile Ser
      50                  55                  60                
 Gln Thr Arg Ser Leu Ser Thr Ile Ser Ala Ala Pro Met Lys Lys Thr
  65                  70                  75                  80
 Leu Asn Pro Asp Arg Trp Leu Ala Pro Arg Gln Asp Leu Ser Lys Ile
                  85                  90                  95    
 Met Gly Asp His Leu Asp Leu Leu Leu Gly Val Val Leu Met Ala Gly
             100                 105                 110        
 Pro Val Phe Gly Ile Pro Ser Cys Ser Phe Asp Gly Arg Ile Ala Phe
         115                 120                 125            
 Tyr Arg Phe Cys Asn Leu Thr Gln Val Pro Gln Val Leu Asn Thr Thr
     130                 135                 140                
 Glu Arg Leu Leu Leu Ser Phe Asn Tyr Ile Arg Thr Val Thr Ala Ser
 145                 150                 155                 160
 Ser Phe Pro Phe Leu Glu Gln Leu Gln Leu Leu Glu Leu Gly Ser Gln
                 165                 170                 175    
 Tyr Thr Pro Leu Thr Ile Asp Lys Glu Ala Phe Arg Asn Leu Pro Asn
             180                 185                 190        
 Leu Arg Ile Leu Asp Leu Gly Ser Ser Lys Ile Tyr Phe Leu His Pro
         195                 200                 205            
 Asp Ala Phe Gln Gly Leu Phe His Leu Phe Glu Leu Arg Leu Tyr Phe
     210                 215                 220                
 Cys Gly Leu Ser Asp Ala Val Leu Lys Asp Gly Tyr Phe Arg Asn Leu
 225                 230                 235                 240
 Lys Ala Leu Thr Arg Leu Asp Leu Ser Lys Asn Gln Ile Arg Ser Leu
                 245                 250                 255    
 Tyr Leu His Pro Ser Phe Gly Lys Leu Asn Ser Leu Lys Ser Ile Asp
             260                 265                 270        
 Phe Ser Ser Asn Gln Ile Phe Leu Val Cys Glu His Glu Leu Glu Pro
         275                 280                 285            
 Leu Gln Gly Lys Thr Leu Ser Phe Phe Ser Leu Ala Ala Asn Ser Leu
     290                 295                 300                
 Tyr Ser Arg Val Ser Val Asp Trp Gly Lys Cys Met Asn Pro Phe Arg
 305                 310                 315                 320
 Asn Met Val Leu Glu Ile Leu Asp Val Ser Gly Asn Gly Trp Thr Val
                 325                 330                 335    
 Asp Ile Thr Gly Asn Phe Ser Asn Ala Ile Ser Lys Ser Gln Ala Phe
             340                 345                 350        
 Ser Leu Ile Leu Ala His His Ile Met Gly Ala Gly Phe Gly Phe His
         355                 360                 365            
 Asn Ile Lys Asp Pro Asp Gln Asn Thr Phe Ala Gly Leu Ala Arg Ser
     370                 375                 380                
 Ser Val Arg His Leu Asp Leu Ser His Gly Phe Val Phe Ser Leu Asn
 385                 390                 395                 400
 Ser Arg Val Phe Glu Thr Leu Lys Asp Leu Lys Val Leu Asn Leu Ala
                 405                 410                 415    
 Tyr Asn Lys Ile Asn Lys Ile Ala Asp Glu Ala Phe Tyr Gly Leu Asp
             420                 425                 430        
 Asn Leu Gln Val Leu Asn Leu Ser Tyr Asn Leu Leu Gly Glu Leu Tyr
         435                 440                 445            
 Ser Ser Asn Phe Tyr Gly Leu Pro Lys Val Ala Tyr Ile Asp Leu Gln
     450                 455                 460                
 Lys Asn His Ile Ala Ile Ile Gln Asp Gln Thr Phe Lys Phe Leu Glu
 465                 470                 475                 480
 Lys Leu Gln Thr Leu Asp Leu Arg Asp Asn Ala Leu Thr Thr Ile His
                 485                 490                 495    
 Phe Ile Pro Ser Ile Pro Asp Ile Phe Leu Ser Gly Asn Lys Leu Val
             500                 505                 510        
 Thr Leu Pro Lys Ile Asn Leu Thr Ala Asn Leu Ile His Leu Ser Glu
         515                 520                 525            
 Asn Arg Leu Glu Asn Leu Asp Ile Leu Tyr Phe Leu Leu Arg Val Pro
     530                 535                 540                
 His Leu Gln Ile Leu Ile Leu Asn Gln Asn Arg Phe Ser Ser Cys Ser
 545                 550                 555                 560
 Gly Asp Gln Thr Pro Ser Glu Asn Pro Ser Leu Glu Gln Leu Phe Leu
                 565                 570                 575    
 Gly Glu Asn Met Leu Gln Leu Ala Trp Glu Thr Glu Leu Cys Trp Asp
             580                 585                 590        
 Val Phe Glu Gly Leu Ser His Leu Gln Val Leu Tyr Leu Asn His Asn
         595                 600                 605            
 Tyr Leu Asn Ser Leu Pro Pro Gly Val Phe Ser His Leu Thr Ala Leu
     610                 615                 620                
 Arg Gly Leu Ser Leu Asn Ser Asn Arg Leu Thr Val Leu Ser His Asn
 625                 630                 635                 640
 Asp Leu Pro Ala Asn Leu Glu Ile Leu Asp Ile Ser Arg Asn Gln Leu
                 645                 650                 655    
 Leu Ala Pro Asn Pro Asp Val Phe Val Ser Leu Ser Val Leu Asp Ile
             660                 665                 670        
 Thr His Asn Lys Phe Ile Cys Glu Cys Glu Leu Ser Thr Phe Ile Asn
         675                 680                 685            
 Trp Leu Asn His Thr Asn Val Thr Ile Ala Gly Pro Pro Ala Asp Ile
     690                 695                 700                
 Tyr Cys Val Tyr Pro Asp Ser Phe Ser Gly Val Ser Leu Phe Ser Leu
 705                 710                 715                 720
 Ser Thr Glu Gly Cys Asp Glu Glu Glu Val Leu Lys Ser Leu Lys Phe
                 725                 730                 735    
 Ser Leu Phe Ile Val Cys Thr Val Thr Leu Thr Leu Phe Leu Met Thr
             740                 745                 750        
 Ile Leu Thr Val Thr Lys Phe Arg Gly Phe Cys Phe Ile Cys Tyr Lys
         755                 760                 765            
 Thr Ala Gln Arg Leu Val Phe Lys Asp His Pro Gln Gly Thr Glu Pro
     770                 775                 780                
 Asp Met Tyr Lys Tyr Asp Ala Tyr Leu Cys Phe Ser Ser Lys Asp Phe
 785                 790                 795                 800
 Thr Trp Val Gln Asn Ala Leu Leu Lys His Leu Asp Thr Gln Tyr Ser
                 805                 810                 815    
 Asp Gln Asn Arg Phe Asn Leu Cys Phe Glu Glu Arg Asp Phe Val Pro
             820                 825                 830        
 Gly Glu Asn Arg Ile Ala Asn Ile Gln Asp Ala Ile Trp Asn Ser Arg
         835                 840                 845            
 Lys Ile Val Cys Leu Val Ser Arg His Phe Leu Arg Asp Gly Trp Cys
     850                 855                 860                
 Leu Glu Ala Phe Ser Tyr Ala Gln Gly Arg Cys Leu Ser Asp Leu Asn
 865                 870                 875                 880
 Ser Ala Leu Ile Met Val Val Val Gly Ser Leu Ser Gln Tyr Gln Leu
                 885                 890                 895    
 Met Lys His Gln Ser Ile Arg Gly Phe Val Gln Lys Gln Gln Tyr Leu
             900                 905                 910        
 Arg Trp Pro Glu Asp Leu Gln Asp Val Gly Trp Phe Leu His Lys Leu
         915                 920                 925            
 Ser Gln Gln Ile Leu Lys Lys Glu Lys Glu Lys Lys Lys Asp Asn Asn
     930                 935                 940                
 Ile Pro Leu Gln Thr Val Ala Thr Ile Ser
 945                 950                



      <210> 1787
      <211> 367
      <212> PRT
      <213> Homo sapiens


      <400> 1787
 Met Thr Ala Gly Gly Gln Ala Glu Ala Glu Gly Ala Gly Gly Glu Pro
   1               5                  10                  15    
 Gly Ala Ala Arg Leu Pro Ser Arg Val Ala Arg Leu Leu Ser Ala Leu
              20                  25                  30        
 Phe Tyr Gly Thr Cys Ser Phe Leu Ile Val Leu Val Asn Lys Ala Leu
          35                  40                  45            
 Leu Thr Thr Tyr Gly Phe Pro Ser Pro Ile Phe Leu Gly Ile Gly Gln
      50                  55                  60                
 Met Ala Ala Thr Ile Met Ile Leu Tyr Val Ser Lys Leu Asn Lys Ile
  65                  70                  75                  80
 Ile His Phe Pro Asp Phe Asp Lys Lys Ile Pro Val Lys Leu Leu Ser
                  85                  90                  95    
 Gly Cys Ser Val Val Asp Asp Val Lys Pro Val Leu Gly Lys Gln Tyr
             100                 105                 110        
 Ser Leu Asn Ile Ile Leu Ser Val Phe Ala Ile Ile Leu Gly Ala Phe
         115                 120                 125            
 Ile Ala Ala Gly Ser Asp Leu Ala Phe Asn Leu Glu Gly Tyr Ile Phe
     130                 135                 140                
 Val Phe Leu Asn Asp Ile Phe Thr Ala Ala Asn Gly Val Tyr Thr Lys
 145                 150                 155                 160
 Gln Lys Met Asp Pro Lys Glu Leu Gly Lys Tyr Gly Val Leu Phe Tyr
                 165                 170                 175    
 Asn Ala Cys Phe Met Ile Ile Pro Thr Leu Ile Ile Ser Val Ser Thr
             180                 185                 190        
 Gly Asp Leu Gln Gln Leu Phe Val Pro Leu Glu Tyr Phe Lys Thr Tyr
         195                 200                 205            
 Pro Ser His His Ala Ile Leu Pro Leu Asn Ile Pro Gly Ser Thr Phe
     210                 215                 220                
 Glu Phe Trp Glu Gly Val Val Leu Ser Ala Phe Ala Leu Lys Pro Tyr
 225                 230                 235                 240
 Leu Leu Leu Val Ser Ala Asp Val Leu His Gly Ser Val Gln Leu Leu
                 245                 250                 255    
 Gln Phe Ser Pro Asp Asp Ser Ser Gly Trp Ser His Gln Glu Cys Ile
             260                 265                 270        
 Arg Cys Leu His Trp Asp Ile Asn Arg Trp Arg Leu His Phe Leu Phe
         275                 280                 285            
 Val Lys Leu Cys Arg Val Lys Tyr Leu Val Cys Ser Gly Ala Phe Thr
     290                 295                 300                
 Thr Gly Ala Phe Pro His Met Leu Thr Tyr Arg Gln Pro Leu Val Tyr
 305                 310                 315                 320
 Gly Lys Glu Ala Gln Met Asp Arg Leu Asp Leu Val Glu Val Leu Pro
                 325                 330                 335    
 Gln Val Gly Ile Ala Lys Lys Gly Ser Phe Ser Ser Arg Phe Leu Gly
             340                 345                 350        
 Asn Trp Ile Gln Leu Gly Glu Asp His Leu Asn Ser His Pro Ile
         355                 360                 365        



      <210> 1788
      <211> 308
      <212> PRT
      <213> Homo sapiens


      <400> 1788
 Met Leu Gln Gln Asp Ser Asn Asp Asp Thr Lys Asp Val Ser Leu Phe
   1               5                  10                  15    
 Asp Ala Glu Glu Glu Thr Thr Asn Arg Pro Arg Lys Val Lys Ile Arg
              20                  25                  30        
 His Pro Val Ala Ser Phe Phe His Leu Phe Phe Arg Val Ser Ala Ile
          35                  40                  45            
 Ile Val Cys Leu Leu Cys Glu Leu Leu Ser Ser Ser Phe Ile Thr Cys
      50                  55                  60                
 Met Val Thr Ile Ile Leu Leu Ser Cys Asp Phe Trp Ala Val Lys Asn
  65                  70                  75                  80
 Ile Thr Gly Arg Leu Met Val Gly Leu Arg Trp Trp Asn His Val Asp
                  85                  90                  95    
 Glu Asp Gly Lys Ser His Trp Val Phe Glu Ser Arg Lys Glu Ser Ser
             100                 105                 110        
 Gln Glu Asn Glu Thr Val Ser Glu Ala Glu Ser Gly Ile Phe Trp Leu
         115                 120                 125            
 Gly Leu Val Ala Cys Pro Val Leu Trp Val Ile Leu Ala Phe Ser Ala
     130                 135                 140                
 Arg Phe Ser Phe Arg Val Lys Ser Gly Trp Arg Trp Leu Ser Trp Val
 145                 150                 155                 160
 Trp Cys Tyr Lys Val Pro Thr Cys Met Val Thr Ser Gly Val Arg Tyr
                 165                 170                 175    
 Leu Val Ser Glu Leu Asn His Trp Thr Pro Ser Trp Ala Ser Arg Ile
             180                 185                 190        
 Gly Glu Leu Val Gly Met Arg Glu Lys Pro Thr His Leu Val Ser Glu
         195                 200                 205            
 Val Leu Glu Ile Glu Thr Asp Gln Asn Asp Thr His Pro Cys Leu Leu
     210                 215                 220                
 Gln Leu Arg Leu Gln Gln Arg Arg Thr Arg Glu Gln Leu Val Asp Gln
 225                 230                 235                 240
 Gly Ile Met Pro Gln Thr Phe Ala Glu Pro Ser Leu Gln Ala Thr Gln
                 245                 250                 255    
 Met Lys Leu Lys Arg Ala Arg Leu Ala Asp Asp Leu Asn Glu Lys Ile
             260                 265                 270        
 Ala Gln Arg Pro Gly Pro Met Glu Leu Val Glu Lys Asn Ile Leu Pro
         275                 280                 285            
 Val Asp Ser Ser Val Lys Glu Ala Ile Ile Gly Lys Thr Leu Lys Ile
     290                 295                 300                
 Tyr Tyr Leu Gly
 305            



      <210> 1789
      <211> 540
      <212> PRT
      <213> Homo sapiens


      <400> 1789
 Met Ala Leu Thr Ile Ala Thr Gly Phe Val Val Asp Asp Ala Ile Val
   1               5                  10                  15    
 Val Leu Glu Asn Ile Ala Arg His Leu Glu Ala Gly Met Lys Pro Leu
              20                  25                  30        
 Gln Ala Ala Leu Gln Gly Thr Arg Glu Val Gly Phe Thr Val Leu Ser
          35                  40                  45            
 Met Ser Leu Ser Leu Val Ala Val Phe Leu Pro Leu Leu Leu Met Gly
      50                  55                  60                
 Gly Leu Pro Gly Arg Leu Leu Arg Glu Phe Ala Val Thr Leu Ser Val
  65                  70                  75                  80
 Ala Ile Gly Ile Ser Leu Leu Val Ser Leu Thr Leu Thr Pro Met Met
                  85                  90                  95    
 Cys Gly Trp Met Leu Lys Ala Ser Lys Pro Arg Glu Gln Lys Arg Leu
             100                 105                 110        
 Arg Gly Phe Gly Arg Met Leu Val Ala Leu Gln Gln Gly Tyr Gly Lys
         115                 120                 125            
 Ser Leu Lys Trp Val Leu Asn His Thr Arg Leu Val Gly Val Val Leu
     130                 135                 140                
 Leu Gly Thr Ile Ala Leu Asn Ile Trp Leu Tyr Ile Ser Ile Pro Lys
 145                 150                 155                 160
 Thr Phe Phe Pro Glu Gln Asp Thr Gly Val Leu Met Gly Gly Ile Gln
                 165                 170                 175    
 Ala Asp Gln Ser Ile Ser Phe Gln Ala Met Arg Gly Lys Leu Gln Asp
             180                 185                 190        
 Phe Met Lys Ile Ile Arg Asp Asp Pro Ala Val Asp Asn Val Thr Gly
         195                 200                 205            
 Phe Thr Gly Gly Ser Arg Val Asn Ser Gly Met Met Phe Ile Thr Leu
     210                 215                 220                
 Lys Pro Arg Asp Glu Arg Ser Glu Thr Ala Gln Gln Ile Ile Asp Arg
 225                 230                 235                 240
 Leu Arg Val Lys Leu Ala Lys Glu Pro Gly Ala Asn Leu Phe Leu Met
                 245                 250                 255    
 Ala Val Gln Asp Ile Arg Val Gly Gly Arg Gln Ser Asn Ala Ser Tyr
             260                 265                 270        
 Gln Tyr Thr Leu Leu Ser Asp Asp Leu Ala Ala Leu Arg Glu Trp Glu
         275                 280                 285            
 Pro Lys Ile Arg Lys Lys Leu Ala Thr Leu Pro Glu Leu Ala Asp Val
     290                 295                 300                
 Asn Ser Asp Gln Gln Asp Asn Gly Ala Glu Met Asn Leu Val Tyr Asp
 305                 310                 315                 320
 Arg Asp Thr Met Ala Arg Leu Gly Ile Asp Val Gln Ala Ala Asn Ser
                 325                 330                 335    
 Leu Leu Asn Asn Ala Phe Gly Gln Arg Gln Ile Ser Thr Ile Tyr Gln
             340                 345                 350        
 Pro Met Asn Gln Tyr Lys Val Val Met Glu Val Asp Pro Arg Tyr Thr
         355                 360                 365            
 Gln Asp Ile Ser Ala Leu Glu Lys Met Phe Val Ile Asn Asn Glu Gly
     370                 375                 380                
 Lys Ala Ile Pro Leu Ser Tyr Phe Ala Lys Trp Gln Pro Ala Asn Ala
 385                 390                 395                 400
 Pro Leu Ser Val Asn His Gln Gly Leu Ser Ala Ala Ser Thr Ile Ser
                 405                 410                 415    
 Phe Asn Leu Pro Thr Gly Lys Ser Leu Ser Asp Ala Ser Ala Ala Ile
             420                 425                 430        
 Asp Arg Ala Met Thr Gln Leu Gly Val Pro Ser Thr Val Arg Gly Ser
         435                 440                 445            
 Phe Ala Gly Thr Gly Ala Gly Val Pro Gly Asp Asp Glu Leu Ala Gly
     450                 455                 460                
 Asp Pro Asp Tyr Arg Arg His Arg His Gly Val Tyr Arg Ala Gly Tyr
 465                 470                 475                 480
 Pro Leu Arg Glu Leu Arg Thr Ser Ala Asp Asp Ser Leu His Pro Ala
                 485                 490                 495    
 Leu Gly Gly Arg Trp Ser Ala Val Gly Ala Gly Ala Val Gln Cys Pro
             500                 505                 510        
 Val Gln Pro Asn Arg Pro Asp Arg Asp His Ala Ile Asn Arg His Arg
         515                 520                 525            
 Glu Glu Lys Arg His Tyr Asp Gly Arg Phe Cys Ala
     530                 535                 540



      <210> 1790
      <211> 203
      <212> PRT
      <213> Homo sapiens


      <400> 1790
 Met Thr Leu Leu Ile Ala Thr Val Gly Ile Asp Leu Ser Val Gly Pro
   1               5                  10                  15    
 Leu Met Ala Ile Ala Gly Ala Thr Thr Ala Ala Met Thr Val Ala Gly
              20                  25                  30        
 Phe Ser Leu Pro Ile Val Leu Leu Ser Ala Leu Gly Thr Gly Ile Leu
          35                  40                  45            
 Ala Gly Leu Trp Asn Gly Ile Leu Val Ala Ile Leu Lys Ile Gln Pro
      50                  55                  60                
 Phe Val Ala Thr Leu Ile Leu Met Val Ala Gly Arg Gly Val Ala Gln
  65                  70                  75                  80
 Leu Ile Thr Ala Gly Gln Ile Val Thr Phe Asn Ser Pro Asp Leu Ser
                  85                  90                  95    
 Trp Phe Gly Ser Gly Ser Leu Leu Phe Leu Pro Thr Pro Val Ile Ile
             100                 105                 110        
 Ala Val Leu Thr Leu Ile Leu Phe Trp Leu Leu Thr Arg Lys Thr Ala
         115                 120                 125            
 Leu Gly Met Phe Ile Glu Ala Val Gly Ile Asn Ile Arg Ala Ala Lys
     130                 135                 140                
 Asn Ala Gly Val Asn Thr Arg Ile Ile Val Met Leu Thr Tyr Val Leu
 145                 150                 155                 160
 Ser Gly Leu Cys Ala Ala Ile Ala Gly Ile Ile Val Ala Ala Asp Ile
                 165                 170                 175    
 Arg Gly Ala Asp Ala Asn Asn Ala Gly Leu Met Ala Gly Ala Asp Ala
             180                 185                 190        
 Ile Thr Arg Gly Gly Asp Leu Ala Ala Asp Arg
         195                 200            



      <210> 1791
      <211> 193
      <212> PRT
      <213> Homo sapiens


      <400> 1791
 Met Gly Trp Pro Pro Cys Gly Arg Thr Met Val His Trp Trp Ser Gln
   1               5                  10                  15    
 Lys Glu Arg Gly Gly Ile Val Ser Val Trp Asn Cys Ala His Asn Val
              20                  25                  30        
 Gly Gly Gly Ile Pro Pro Leu Leu Phe Leu Leu Gly Met Ala Trp Phe
          35                  40                  45            
 Asn Asp Trp His Ala Ala Leu Tyr Met Pro Ala Phe Cys Ala Ile Leu
      50                  55                  60                
 Val Ala Leu Phe Ala Phe Ala Met Met Arg Asp Thr Pro Gln Ser Cys
  65                  70                  75                  80
 Gly Leu Pro Pro Ile Glu Glu Tyr Lys Asn Asp Tyr Pro Asp Asp Tyr
                  85                  90                  95    
 Asn Glu Lys Ala Glu Gln Glu Leu Thr Ala Lys Gln Ile Phe Met Gln
             100                 105                 110        
 Tyr Val Leu Pro Asn Lys Leu Leu Trp Tyr Ile Ala Ile Ala Asn Val
         115                 120                 125            
 Phe Val Tyr Leu Leu Arg Tyr Gly Ile Leu Asp Trp Ser Pro Thr Tyr
     130                 135                 140                
 Leu Lys Glu Val Lys His Phe Ala Leu Asp Lys Ser Ser Trp Ala Tyr
 145                 150                 155                 160
 Phe Leu Tyr Glu Tyr Ala Gly Ile Pro Gly Thr Leu Leu Cys Gly Trp
                 165                 170                 175    
 Met Ser Asp Lys Val Phe Arg Gly Asn Arg Gly Ala Thr Gly Val Ser
             180                 185                 190        
 Leu
    



      <210> 1792
      <211> 1253
      <212> PRT
      <213> Homo sapiens


      <400> 1792
 Met Ser Ala Arg Met Phe Val Leu Cys Cys Ile Trp Phe Ile Val Ala
   1               5                  10                  15    
 Phe Leu Trp Ile Thr Ile Thr Ser Ala Leu Asp Lys Glu Trp Met Ile
              20                  25                  30        
 Asp Gly Arg Gly Ile Asn Asn Val Cys Asp Val Leu Met Tyr Leu Glu
          35                  40                  45            
 Glu Asp Asp Thr Arg Asp Val Gly Val Ile Met Thr Leu Pro Leu Phe
      50                  55                  60                
 Phe Pro Phe Leu Trp Phe Ala Leu Trp Arg Lys Lys Arg Gly Cys Lys
  65                  70                  75                  80
 Ala Met Ser Ile Leu Val Phe Pro Phe Val Gly Val Leu Met Leu Leu
                  85                  90                  95    
 Ala Leu Tyr Leu Ile Pro Gln Trp Asn Gly Ala Ala Leu Glu Thr Leu
             100                 105                 110        
 Ser Leu Asp Thr Ala Ser Ala Thr Gly Asn Gly Leu Trp Met Thr Leu
         115                 120                 125            
 Trp Leu Ala Ile Pro Val Glu Asp Val Pro Gly Lys Lys Lys His Lys
     130                 135                 140                
 Ser Gln Ile Leu Leu Gln Arg Phe Val Asn Asp Met Gly Ala Lys Ala
 145                 150                 155                 160
 Asn Gln Asn Gln Arg Arg Ile Leu Leu Cys Gln Leu Ser Gly Lys Arg
                 165                 170                 175    
 Asn Ala Val Asp Ile Arg Gln Ile Lys Ile His Gln Cys Gly Ser Lys
             180                 185                 190        
 Arg Asn Val His Ala Leu Asn Arg His Arg Glu Gln Leu Ala Ala Gln
         195                 200                 205            
 Val Lys Ala Arg Thr Ala Glu Leu Gln Glu Leu Val Ile Glu His Arg
     210                 215                 220                
 Gln Ala Arg Ala Glu Ala Glu Lys Ala Ser Gln Ala Lys Ser Ala Phe
 225                 230                 235                 240
 Leu Ala Ala Met Ser His Glu Ile Arg Thr Pro Leu Tyr Gly Ala Glu
                 245                 250                 255    
 Gln Ser Val His Asn Asp Trp Lys Ala Thr Gln Ile Lys Val Glu Asp
             260                 265                 270        
 Val Leu Phe Ala Met Val Lys Glu Val Glu Asn Arg Pro Ala Val Ser
         275                 280                 285            
 Leu Lys Thr Ser Pro Glu Leu Ala Glu Leu Leu Arg Gln Gln His Ser
     290                 295                 300                
 Asp Val Arg Pro Ser Arg His Leu Asn Lys Ala His Trp Ser Thr Val
 305                 310                 315                 320
 Tyr Leu Asp Gly Ser Leu Pro Asp Ser Gln Ile Tyr Tyr Leu Val Asp
                 325                 330                 335    
 Ala Ser Tyr Gln Gln Ala Val Asn Leu Leu Pro Glu Glu Lys His Met
             340                 345                 350        
 Lys Leu Trp Val Thr His Ser Gln Phe Ile Val Glu His Ile Asn Ala
         355                 360                 365            
 Met Thr Thr Leu Ala Arg Glu His Arg Ala Leu Pro Pro Glu Leu Ala
     370                 375                 380                
 Gln Glu Tyr Leu Gln Ser Cys Glu Ile Ala Ile Gln Arg Cys Gln Gln
 385                 390                 395                 400
 Arg Leu Glu Tyr Asp Glu Pro Gly Ser Ser Gly Asp Ala Asn Ile Met
                 405                 410                 415    
 Asp Ala Pro Glu Met Gln Pro His Glu Gly Ala Ala Gly Thr Leu Glu
             420                 425                 430        
 Gln His Leu Gln Arg Val Ile Gly His Leu Asn Thr Met His Thr Ile
         435                 440                 445            
 Ser Ser Met Ala Trp Arg His Gln Asp Pro His Ala Gly Asp Ala Ala
     450                 455                 460                
 Glu Met Pro Val Ala Glu Leu Pro Asn Arg Ile Ile Arg Met Leu Ala
 465                 470                 475                 480
 Gly Asp Phe Phe Gln Cys Ala Asn Leu Leu Phe His Arg Lys Thr Arg
                 485                 490                 495    
 Trp Gln Ala Met Val Lys Asn Val Ile Ser Gln His Ala Gln Ala Ser
             500                 505                 510        
 Gly Asp Gly Leu Arg Ile Pro Ala Asp Asn Phe Phe Arg Met Ala Thr
         515                 520                 525            
 Leu Asp Gln Leu Leu His Leu Phe Arg Leu Met Gln Thr Asp Arg Asn
     530                 535                 540                
 Met Phe Leu Val Thr His Arg His Ala Ala Thr Ile Leu Thr Gly Gln
 545                 550                 555                 560
 Tyr Ser Ile His His Gly Ile Leu Met Pro Pro Met Tyr Gly Gln Pro
                 565                 570                 575    
 Gly Gly Leu Gln Gly Leu Thr Thr Leu Pro Gln Leu Leu His Asp Gln
             580                 585                 590        
 Gly Tyr Val Thr Gln Ala Ile Gly Lys Trp His Met Gly Glu Asn Lys
         595                 600                 605            
 Glu Ser Gln Pro Gln Asn Val Gly Phe Asp Asp Phe Arg Gly Phe Asn
     610                 615                 620                
 Ser Val Ser Asp Met Tyr Thr Glu Trp Arg Asp Val His Val Asn Pro
 625                 630                 635                 640
 Glu Val Ala Leu Ser Pro Asp Arg Ser Glu Tyr Ile Lys Gln Leu Pro
                 645                 650                 655    
 Phe Ser Lys Asp Asp Val His Ala Val Arg Gly Gly Glu Gln Gln Ala
             660                 665                 670        
 Ile Ala Asp Ile Thr Pro Asn Phe Lys Leu Lys Ser Lys Met Gly Glu
         675                 680                 685            
 Glu Phe Phe Phe Gln Thr Thr Asp Arg Gln Tyr Leu Thr Thr Gln Ser
     690                 695                 700                
 Asp Leu Thr Gly His Cys His Ile Gly Thr Asn Arg Val Thr Gly Gln
 705                 710                 715                 720
 Ala Arg Asn Gln Arg Gly Ala His Ser Asn Thr Gly Thr Arg Thr Ile
                 725                 730                 735    
 Phe Arg Arg Arg Thr Phe Arg Tyr Val Asp Val Asp Val Thr Phe Phe
             740                 745                 750        
 Phe Ala Phe Thr Arg Asn Thr Cys Gly Phe Asn Gly Gln Gln Val Thr
         755                 760                 765            
 Ala His Phe Arg Pro Arg Gln Thr Gly Tyr Leu Thr Asp Thr Val Phe
     770                 775                 780                
 Val Ile Arg Ala Thr Ile Val Glu Thr Leu Asn Thr Glu Ile Val Met
 785                 790                 795                 800
 Gln Phe Gly Asp Phe Thr Leu Gln Thr Thr His Ala Arg Leu Thr Gly
                 805                 810                 815    
 Val Val Thr Asn Asn Ala Asp Asn Gly Ala Ile Val Asp Gly Gln Leu
             820                 825                 830        
 Thr Phe Phe Gln Cys Ile Thr Phe Asn Leu Leu Arg Gln Gln Val Met
         835                 840                 845            
 Phe Val Ala Thr Ser Thr Arg Val Ala Gly Arg His Asp Met Asp Ser
     850                 855                 860                
 Leu Ala Glu Arg Trp Leu Lys His Lys Thr Ile Thr Phe Glu Glu Ile
 865                 870                 875                 880
 Ala Gly Lys Gly Lys Asn Gln Leu Thr Phe Asn Gln Ile Ala Leu Glu
                 885                 890                 895    
 Glu Ala Gly Arg Tyr Ala Ala Glu Asp Ala Asp Leu Ile Arg His Phe
             900                 905                 910        
 Val Ile Arg Gln His Met Gln Pro Arg Arg Lys Gln Pro Cys Ile Thr
         915                 920                 925            
 Arg Gln Gln Arg Ala Gln Leu Arg Trp His Gln Gln His Arg Val Phe
     930                 935                 940                
 Pro Arg Arg Phe His Leu Leu Phe His Leu Trp His Arg Thr Leu Glu
 945                 950                 955                 960
 Leu Val Ala Arg Tyr Phe Ser Ile Gln Gln Ala Met Gly Asp Gly Glu
                 965                 970                 975    
 Lys Ser Ile Val Gly Asn Ala Asp Ile Glu Thr Cys Ser Ser Phe Tyr
             980                 985                 990        
 Phe Ser Gly Glu Ala Glu Ser Val Pro Ala Val Ser Gln Gly Glu Ile
         995                1000                1005            
 Ser Tyr Pro Ala Phe Val Arg Ser Thr Leu Gly Leu Gly Pro Thr Asp
    1010                1015                1020                
 Thr Gly Pro Val Ser Ala Ser Arg Val Tyr Arg Gln Val Asn Ile Lys
1025                1030                1035                1040
 Gln Arg Tyr Trp Gly Ile Phe Gly Gly Ala Ile Ala Asp Arg Phe Gly
                1045                1050                1055    
 Ala Lys Pro Met Ile Val Thr Gly Met Leu Met Arg Ala Ala Gly Phe
            1060                1065                1070        
 Ala Thr Met Gly Ile Ala His Glu Pro Trp Leu Leu Trp Phe Ser Cys
        1075                1080                1085            
 Leu Leu Ser Gly Leu Gly Gly Thr Leu Phe Asp Pro Pro Arg Ser Ala
    1090                1095                1100                
 Leu Val Val Lys Leu Ile Arg Pro Gln Gln Arg Gly Arg Phe Phe Ser
1105                1110                1115                1120
 Leu Leu Met Met Gln Asp Ser Ala Gly Ala Val Ile Gly Ala Leu Leu
                1125                1130                1135    
 Gly Ser Trp Leu Leu Gln Tyr Asp Phe Arg Leu Val Cys Ala Thr Gly
            1140                1145                1150        
 Ala Val Leu Phe Val Leu Cys Ala Ala Phe Asn Ala Trp Leu Leu Pro
        1155                1160                1165            
 Ala Trp Lys Leu Ser Thr Val Arg Thr Pro Val Arg Glu Gly Met Thr
    1170                1175                1180                
 Arg Val Met Arg Asp Lys Arg Phe Val Thr Tyr Val Leu Thr Leu Ala
1185                1190                1195                1200
 Gly Tyr Tyr Met Leu Ala Val Gln Val Met Leu Met Leu Pro Ile Met
                1205                1210                1215    
 Val Asn Asp Val Ala Gly Ala Pro Ser Ala Val Lys Trp Met Tyr Ala
            1220                1225                1230        
 Asn Arg Glu Ala Pro Pro Leu Lys Arg Tyr Ala Tyr Trp Lys Arg Lys
        1235                1240                1245            
 Ala Ser Val Leu Gln
    1250            



      <210> 1793
      <211> 105
      <212> PRT
      <213> Homo sapiens

      <220>
      <221> misc_feature
      <222> (1)...(105)
      <223> Xaa = any amino acid or nothing 


      <400> 1793
 Met Ala Leu Ala Ile Gly Ser Gly Val Ala Pro Gln Tyr Gly Leu Tyr
   1               5                  10                  15    
 Thr Ala Ala Val Ala Gly Ile Val Ile Ala Leu Thr Gly Gly Ser Arg
              20                  25                  30        
 Phe Ser Val Ser Gly Pro Thr Ala Ala Phe Val Val Ile Leu Tyr Pro
          35                  40                  45            
 Val Ser Gln Gln Phe Gly Leu Ala Gly Leu Leu Val Ala Thr Leu Leu
      50                  55                  60                
 Val Xaa Ile Phe Leu Ile Leu Met Gly Leu Ala Arg Phe Gly Arg Leu
  65                  70                  75                  80
 Ile Glu Tyr Ile Xaa Gly Ser Val Thr Leu Ser Phe Thr Ser Gly Ile
                  85                  90                  95    
 Gly Asp His Gln Ser Asp His Ala Glu
             100                 105



      <210> 1794
      <211> 181
      <212> PRT
      <213> Homo sapiens


      <400> 1794
 Met Thr Phe Val Gly Ser Met Ser Gly Ala Leu Leu Val Gln Tyr Val
   1               5                  10                  15    
 Gln Ala Asp Val Leu Arg Gln Ile Leu Pro Ile Leu Val Ile Cys Ile
              20                  25                  30        
 Gly Leu Tyr Phe Leu Leu Met Pro Lys Leu Gly Glu Glu Asp Arg Gln
          35                  40                  45            
 Arg Arg Met Tyr Gly Leu Pro Phe Ala Leu Ile Ala Gly Gly Cys Val
      50                  55                  60                
 Gly Phe Tyr Asp Gly Phe Phe Gly Pro Ala Ala Gly Ser Phe Tyr Ala
  65                  70                  75                  80
 Leu Ala Phe Val Thr Leu Cys Gly Phe Asn Leu Ala Lys Ala Thr Ala
                  85                  90                  95    
 His Ala Lys Leu Leu Asn Ala Thr Ser Asn Ile Gly Gly Leu Leu Leu
             100                 105                 110        
 Phe Ile Leu Gly Gly Lys Val Ile Trp Ala Thr Gly Phe Val Met Leu
         115                 120                 125            
 Val Gly Gln Phe Leu Gly Ala Arg Met Gly Ser Arg Leu Val Leu Ser
     130                 135                 140                
 Lys Gly Gln Lys Leu Ile Arg Pro Met Ile Val Ile Val Ser Ala Val
 145                 150                 155                 160
 Met Ser Ala Lys Leu Leu Tyr Asp Ser His Gly Gln Glu Ile Leu His
                 165                 170                 175    
 Trp Leu Gly Met Asn
             180    



      <210> 1795
      <211> 116
      <212> PRT
      <213> Homo sapiens


      <400> 1795
 Met Leu Arg His Leu Ala Arg Leu Ala Phe Ser Leu Gly Asp Val Glu
   1               5                  10                  15    
 Thr Ala Tyr Leu Pro Ala Ser Leu Ser Glu Val Glu Glu Ala Arg Asp
              20                  25                  30        
 Trp Leu Leu Leu Lys Ala Leu Val Lys Tyr Asp Leu Asn Asn Pro Ala
          35                  40                  45            
 Lys His Ala Lys Leu Asp Phe Leu Asn Asn Leu Ala Thr Gly Leu Val
      50                  55                  60                
 Phe Ile Ile Val Val Val Asn Ile Phe Ile Thr Ala Phe Gly Val Gln
  65                  70                  75                  80
 Lys Pro Trp Ala Glu Pro Arg Asp Leu Gly Trp Leu Gln Leu Pro Phe
                  85                  90                  95    
 Leu Gly Trp Met Ser Gly Pro His Leu Gln Ser Cys Val Trp Ala Asp
             100                 105                 110        
 Ile Arg Ser Ala
         115    



      <210> 1796
      <211> 1512
      <212> PRT
      <213> Homo sapiens


      <400> 1796
 Met Arg Gly Ala Pro Ala Arg Leu Leu Leu Pro Leu Leu Pro Trp Leu
   1               5                  10                  15    
 Leu Leu Leu Leu Ala Pro Glu Ala Arg Gly Ala Pro Gly Cys Pro Leu
              20                  25                  30        
 Ser Ile Arg Ser Cys Lys Cys Ser Gly Glu Arg Pro Lys Gly Leu Ser
          35                  40                  45            
 Gly Gly Val Pro Gly Pro Ala Arg Arg Arg Val Val Cys Ser Gly Gly
      50                  55                  60                
 Asp Leu Pro Glu Pro Pro Glu Pro Gly Leu Leu Pro Asn Gly Thr Val
  65                  70                  75                  80
 Thr Leu Gly Asn Arg Phe Ser Thr Ala Pro Cys Pro Gln Ser Gly Leu
                  85                  90                  95    
 Ala Gln Ser Phe Arg Leu Cys Pro Glu Gln Tyr Ser Asn Ala Ser Gly
             100                 105                 110        
 Trp Val Ser Ser Glu Ala Ala Arg Phe Leu Thr Gly His Asn Trp Ser
         115                 120                 125            
 Ala Ser Asp Ala Gly Arg Pro Ala Cys Ile Phe Pro Gly Pro Val Ser
     130                 135                 140                
 Trp Arg Gln Val Pro Ala Tyr Asn Ala Gly Gln Asp Gln Gly Ser Lys
 145                 150                 155                 160
 Tyr Ser Phe Tyr Gly Gly Lys Val Lys Asp Glu Tyr Leu Arg Arg Ser
                 165                 170                 175    
 Pro Ile Cys Arg Ser Ala Ala Ala Leu His Thr Asp Thr Ser Ala Arg
             180                 185                 190        
 Ser Trp Ser Glu Phe Arg Leu Leu Ser Asn Asn Lys Ile Thr Gly Leu
         195                 200                 205            
 Arg Asn Gly Ser Phe Leu Gly Leu Ser Leu Leu Glu Lys Leu Leu Met
     210                 215                 220                
 Arg Ala His Phe Ser Asp Glu Asp Glu Lys Thr Ala Cys Pro Ser Pro
 225                 230                 235                 240
 Ala Pro Arg Leu Trp Arg Leu His Ser Lys Cys Thr Leu Ser Met Ala
                 245                 250                 255    
 Gly Asn Gln Lys Asn Gln Gly Gly Ser Ser Ser Gln Glu Ala Ala Ser
             260                 265                 270        
 Gly Leu Met Pro Ser Arg Arg Leu Gln Arg Gly Glu Val Glu Gly Leu
         275                 280                 285            
 Cys Thr Cys Leu Cys Thr Asp Leu Arg Asn Asn Ile Ile Ser Thr Val
     290                 295                 300                
 Gln Pro Gly Ala Phe Leu Gly Leu Gly Glu Leu Lys Arg Leu Asp Leu
 305                 310                 315                 320
 Ser Asn Asn Arg Ile Gly Cys Leu Thr Ser Glu Thr Phe Gln Gly Leu
                 325                 330                 335    
 Pro Arg Leu Leu Arg Leu Asn Ile Ser Gly Asn Ile Phe Ser Ser Leu
             340                 345                 350        
 Gln Pro Gly Val Phe Asp Glu Leu Pro Ala Leu Lys Val Val Asp Leu
         355                 360                 365            
 Gly Thr Glu Phe Leu Thr Cys Asp Cys His Leu Arg Trp Leu Leu Pro
     370                 375                 380                
 Trp Ala Gln Asn Arg Ser Leu Gln Leu Ser Glu His Thr Leu Cys Ala
 385                 390                 395                 400
 Tyr Pro Ser Ala Leu His Ala His Ala Leu Gly Ser Leu Gln Glu Ala
                 405                 410                 415    
 Gln Leu Cys Cys Glu Gly Ala Leu Glu Leu His Thr His His Leu Ile
             420                 425                 430        
 Pro Ser Leu Arg Gln Val Val Phe Gln Gly Asp Arg Leu Pro Phe Gln
         435                 440                 445            
 Cys Ser Ala Ser Tyr Leu Gly Asn Asp Thr Arg Ile Arg Trp Tyr His
     450                 455                 460                
 Asn Arg Ala Pro Val Glu Gly Asp Glu Gln Ala Gly Ile Leu Leu Ala
 465                 470                 475                 480
 Glu Ser Leu Ile His Asp Cys Thr Phe Ile Thr Ser Glu Leu Thr Leu
                 485                 490                 495    
 Ser His Ile Gly Val Trp Ala Ser Gly Glu Trp Glu Cys Thr Val Ser
             500                 505                 510        
 Met Ala Gln Gly Asn Ala Ser Lys Lys Val Glu Ile Val Val Leu Glu
         515                 520                 525            
 Thr Ser Ala Ser Tyr Cys Pro Ala Glu Arg Val Ala Asn Asn Arg Gly
     530                 535                 540                
 Asp Phe Arg Trp Pro Arg Thr Leu Ala Gly Ile Thr Ala Tyr Gln Ser
 545                 550                 555                 560
 Cys Leu Gln Tyr Pro Phe Thr Ser Val Pro Leu Gly Gly Gly Ala Pro
                 565                 570                 575    
 Gly Thr Arg Ala Ser Arg Arg Cys Asp Arg Ala Gly Arg Trp Glu Pro
             580                 585                 590        
 Gly Asp Tyr Ser His Cys Leu Tyr Thr Asn Asp Ile Thr Arg Val Leu
         595                 600                 605            
 Tyr Thr Phe Val Leu Met Pro Ile Asn Ala Ser Asn Ala Leu Thr Leu
     610                 615                 620                
 Ala His Gln Leu Arg Val Tyr Thr Ala Glu Ala Ala Ser Phe Ser Asp
 625                 630                 635                 640
 Met Met Asp Val Val Tyr Val Ala Gln Met Ile Gln Lys Phe Leu Gly
                 645                 650                 655    
 Tyr Val Asp Gln Ile Lys Glu Leu Val Glu Val Met Val Asp Met Pro
             660                 665                 670        
 Ser Asn Leu Met Leu Val Asp Glu His Leu Leu Trp Leu Ala Gln Arg
         675                 680                 685            
 Glu Asp Lys Ala Cys Ser Arg Ile Val Gly Ala Ile Glu Arg Ile Gly
     690                 695                 700                
 Gly Ala Ala Leu Ser Pro His Ala Gln His Ile Ser Val Asn Ala Arg
 705                 710                 715                 720
 Asn Val Ala Leu Glu Ala Tyr Leu Ile Lys Pro His Ser Tyr Val Gly
                 725                 730                 735    
 Leu Thr Cys Thr Ala Phe Gln Arg Arg Glu Gly Gly Val Pro Gly Thr
             740                 745                 750        
 Arg Pro Gly Ser Pro Gly Gln Asn Pro Pro Pro Glu Pro Glu Pro Pro
         755                 760                 765            
 Ala Asp Gln Gln Leu Arg Phe Arg Cys Thr Thr Gly Arg Pro Asn Val
     770                 775                 780                
 Ser Leu Ser Ser Phe His Ile Lys Asn Ser Val Ala Leu Ala Ser Ile
 785                 790                 795                 800
 Gln Leu Pro Pro Ser Leu Phe Ser Ser Leu Pro Ala Ala Leu Ala Pro
                 805                 810                 815    
 Pro Val Pro Pro Asp Cys Thr Leu Gln Leu Leu Val Phe Arg Asn Gly
             820                 825                 830        
 Arg Leu Phe His Ser His Ser Asn Thr Ser Arg Pro Gly Ala Ala Gly
         835                 840                 845            
 Pro Gly Lys Arg Arg Gly Val Ala Thr Pro Val Ile Phe Ala Gly Thr
     850                 855                 860                
 Ser Gly Cys Gly Val Gly Asn Leu Thr Glu Pro Val Ala Val Ser Leu
 865                 870                 875                 880
 Arg His Trp Ala Glu Gly Ala Glu Pro Val Ala Ala Trp Trp Ser Gln
                 885                 890                 895    
 Glu Gly Pro Gly Glu Ala Gly Gly Trp Thr Ser Glu Gly Cys Gln Leu
             900                 905                 910        
 Arg Ser Ser Gln Pro Asn Val Ser Ala Leu His Cys Gln His Leu Gly
         915                 920                 925            
 Asn Val Ala Val Leu Met Glu Leu Ser Ala Phe Pro Arg Glu Leu Gly
     930                 935                 940                
 Gly Ala Gly Ala Ser Ser Ile Arg Val Ser Arg Lys Gly Trp His Met
 945                 950                 955                 960
 Leu Leu Asn Leu Cys Phe His Ile Ala Met Thr Ser Ala Val Phe Ala
                 965                 970                 975    
 Gly Gly Ile Thr Leu Thr Asn Tyr Gln Met Val Cys Gln Ala Val Gly
             980                 985                 990        
 Ile Thr Leu His Tyr Ser Ser Leu Ser Thr Leu Leu Trp Met Gly Val
         995                1000                1005            
 Lys Ala Arg Val Leu His Lys Glu Leu Thr Trp Arg Ala Pro Pro Pro
    1010                1015                1020                
 Gln Glu Gly Asp Pro Ala Leu Pro Thr Pro Ser Pro Met Leu Arg Tyr
1025                1030                1035                1040
 Ile Leu Ser Ile Pro Ala Leu Gln Leu Gly Arg Asp Ser Asn Ala Gly
                1045                1050                1055    
 Val Gly Asn Leu Pro Arg Phe Tyr Leu Ile Ala Gly Gly Ile Pro Leu
            1060                1065                1070        
 Ile Ile Cys Gly Ile Thr Ala Ala Val Asn Ile His Asn Tyr Arg Asp
        1075                1080                1085            
 His Ser Pro Tyr Cys Trp Leu Val Trp Arg Pro Ser Leu Gly Ala Phe
    1090                1095                1100                
 Tyr Ile Pro Val Ala Leu Ile Leu Leu Ile Thr Trp Ile Tyr Phe Leu
1105                1110                1115                1120
 Cys Ala Gly Leu Arg Leu Arg Gly Pro Leu Ala Gln Asn Pro Lys Ala
                1125                1130                1135    
 Gly Asn Ser Arg Ala Ser Leu Glu Ala Gly Glu Glu Leu Arg Gly Ser
            1140                1145                1150        
 Thr Arg Leu Arg Gly Ser Gly Pro Leu Leu Ser Asp Ser Gly Ser Leu
        1155                1160                1165            
 Leu Ala Thr Gly Ser Ala Arg Val Gly Thr Pro Gly Pro Pro Glu Asp
    1170                1175                1180                
 Gly Asp Ser Leu Tyr Ser Pro Gly Val Gln Leu Gly Ala Leu Val Thr
1185                1190                1195                1200
 Thr His Phe Leu Tyr Leu Ala Met Trp Ala Cys Gly Ala Leu Ala Val
                1205                1210                1215    
 Ser Gln Arg Trp Leu Pro Arg Val Val Cys Ser Cys Leu Tyr Gly Val
            1220                1225                1230        
 Ala Ala Ser Ala Leu Gly Leu Phe Val Phe Thr His His Cys Ala Arg
        1235                1240                1245            
 Arg Arg Asp Val Arg Ala Ser Trp Arg Ala Cys Cys Pro Pro Ala Ser
    1250                1255                1260                
 Pro Ala Ala Pro His Ala Pro Pro Arg Ala Leu Pro Ala Ala Ala Glu
1265                1270                1275                1280
 Asp Gly Ser Pro Val Phe Gly Glu Gly Pro Pro Ser Leu Lys Ser Ser
                1285                1290                1295    
 Pro Ser Gly Ser Ser Gly His Pro Leu Ala Leu Gly Pro Cys Lys Leu
            1300                1305                1310        
 Thr Asn Leu Gln Leu Ala Gln Ser Gln Val Cys Glu Ala Gly Ala Ala
        1315                1320                1325            
 Ala Gly Gly Glu Gly Glu Pro Glu Pro Ala Gly Thr Arg Gly Asn Leu
    1330                1335                1340                
 Ala His Arg His Pro Asn Asn Val His His Gly Arg Arg Ala His Lys
1345                1350                1355                1360
 Ser Arg Ala Lys Gly His Arg Ala Gly Glu Ala Cys Gly Lys Asn Arg
                1365                1370                1375    
 Leu Lys Ala Leu Arg Gly Gly Ala Ala Gly Ala Leu Glu Leu Leu Ser
            1380                1385                1390        
 Ser Glu Ser Gly Ser Leu His Asn Ser Pro Thr Asp Ser Tyr Leu Gly
        1395                1400                1405            
 Ser Ser Arg Asn Ser Pro Gly Ala Gly Leu Gln Leu Glu Gly Gly Ala
    1410                1415                1420                
 His Ala His Ala Gly Ser Asp Thr Ser Ala Ala Pro Leu Ser Glu Ala
1425                1430                1435                1440
 Gly Arg Ala Gly Gln Arg Arg Ser Ala Ser Arg Asp Ser Leu Lys Gly
                1445                1450                1455    
 Gly Gly Ala Leu Glu Lys Glu Ser His Arg Arg Ser Tyr Pro Leu Asn
            1460                1465                1470        
 Ala Ala Ser Leu Asn Gly Ala Pro Lys Gly Gly Lys Tyr Asp Asp Val
        1475                1480                1485            
 Thr Leu Met Gly Ala Glu Val Ala Ser Gly Gly Cys Met Lys Thr Gly
    1490                1495                1500                
 Leu Trp Lys Ser Glu Thr Thr Val
1505                1510        



      <210> 1797
      <211> 257
      <212> PRT
      <213> Homo sapiens


      <400> 1797
 Met Ala Ser Lys Ile Gly Ser Arg Arg Trp Met Leu Gln Leu Ile Met
   1               5                  10                  15    
 Gln Leu Gly Ser Val Leu Leu Thr Arg Cys Pro Phe Trp Gly Cys Phe
              20                  25                  30        
 Ser Gln Leu Met Leu Tyr Ala Glu Arg Ala Glu Ala Arg Arg Lys Pro
          35                  40                  45            
 Asp Ile Pro Val Pro Tyr Leu Tyr Phe Asp Met Gly Ala Ala Val Leu
      50                  55                  60                
 Cys Ala Ser Phe Met Ser Phe Gly Val Lys Arg Arg Trp Phe Ala Leu
  65                  70                  75                  80
 Gly Ala Ala Leu Gln Leu Ala Ile Ser Thr Tyr Ala Ala Tyr Ile Gly
                  85                  90                  95    
 Gly Tyr Val His Tyr Gly Asp Trp Leu Lys Val Arg Met Tyr Ser Arg
             100                 105                 110        
 Thr Val Ala Ile Ile Gly Gly Phe Leu Val Leu Ala Ser Gly Ala Gly
         115                 120                 125            
 Glu Leu Tyr Arg Arg Lys Pro Arg Ser Arg Ser Leu Gln Ser Thr Gly
     130                 135                 140                
 Gln Val Phe Leu Gly Ile Tyr Leu Ile Cys Val Ala Tyr Ser Leu Gln
 145                 150                 155                 160
 His Ser Lys Glu Asp Arg Leu Ala Tyr Leu Asn His Leu Pro Gly Gly
                 165                 170                 175    
 Glu Leu Met Ile Gln Leu Phe Phe Val Leu Tyr Gly Ile Leu Ala Leu
             180                 185                 190        
 Ala Phe Leu Ser Gly Tyr Tyr Val Thr Leu Ala Ala Gln Ile Leu Ala
         195                 200                 205            
 Val Leu Leu Pro Pro Val Met Leu Leu Ile Asp Gly Asn Val Ala Tyr
     210                 215                 220                
 Trp His Asn Thr Arg Arg Val Glu Phe Trp Asn Gln Met Lys Leu Leu
 225                 230                 235                 240
 Gly Glu Ser Val Gly Ile Phe Gly Thr Ala Val Ile Leu Ala Thr Asp
                 245                 250                 255    
 Gly
    



      <210> 1798
      <211> 368
      <212> PRT
      <213> Homo sapiens


      <400> 1798
 Met Pro Tyr Ile Ser Ala Ser Ile Ile Ile Gln Leu Leu Thr Val Val
   1               5                  10                  15    
 His Pro Thr Leu Ala Glu Ile Lys Lys Glu Gly Glu Ser Gly Arg Arg
              20                  25                  30        
 Lys Ile Ser Gln Tyr Thr Arg Tyr Gly Thr Leu Val Leu Ala Ile Phe
          35                  40                  45            
 Gln Ser Ile Gly Ile Ala Thr Gly Leu Pro Asn Met Pro Gly Met Gln
      50                  55                  60                
 Gly Leu Val Ile Asn Pro Gly Phe Ala Phe Tyr Phe Thr Ala Val Val
  65                  70                  75                  80
 Ser Leu Val Thr Gly Thr Met Phe Leu Met Trp Leu Gly Glu Gln Ile
                  85                  90                  95    
 Thr Glu Arg Gly Ile Gly Asn Gly Ile Ser Ile Ile Ile Phe Ala Gly
             100                 105                 110        
 Ile Val Ala Gly Leu Pro Pro Ala Ile Ala His Thr Ile Glu Gln Ala
         115                 120                 125            
 Arg Gln Gly Asp Leu His Phe Leu Val Leu Leu Leu Val Ala Val Leu
     130                 135                 140                
 Val Phe Ala Val Thr Phe Phe Val Val Phe Val Glu Arg Gly Gln Arg
 145                 150                 155                 160
 Arg Ile Val Val Asn Tyr Ala Lys Arg Gln Gln Gly Arg Arg Val Tyr
                 165                 170                 175    
 Ala Ala Gln Ser Thr His Leu Pro Leu Lys Val Asn Met Ala Gly Gln
             180                 185                 190        
 Gly Thr Arg Gly Thr Ser Leu Cys Pro Thr Val Cys Val Thr Ile Thr
         195                 200                 205            
 Arg Thr Glu Gly Gln Gly Ile Ile Cys Met Phe Asn Phe Asn Ser Ile
     210                 215                 220                
 Val Glu Ser Thr Ser Gln Leu Ala Val Phe Thr Phe Asp Arg Asn Asn
 225                 230                 235                 240
 Leu Thr Val Asp Phe Tyr Val Asn Ala Gly Arg Asn Asn Asp Arg Cys
                 245                 250                 255    
 Phe Ser Asn Thr Arg His Phe Phe Leu Arg Leu Gly Tyr Val Ala Asp
             260                 265                 270        
 Asn Phe Ala Thr Lys Thr Ser Leu Ala Arg Cys Thr Ile Ser His Asn
         275                 280                 285            
 Thr Phe Arg Gly Arg Asn Asn Cys Asp Thr Gln Thr Arg His Asn Phe
     290                 295                 300                
 Arg Gln Leu Ile Phe Thr Phe Ile Asp Ala Gln Thr Trp Ala Ala Asp
 305                 310                 315                 320
 Thr Leu Asn Ala Phe Tyr Asn Ser Phe Ala Leu Glu Ile Leu Gln Ser
                 325                 330                 335    
 Lys Phe Gln Phe Arg Leu Gly Val Ala Phe Asn Phe Lys Ile Phe Asn
             340                 345                 350        
 Lys Thr Ser Leu Pro Phe Tyr Val Leu Ser Arg Asn Leu Arg Pro Pro
         355                 360                 365            





      <210> 1799
      <211> 233
      <212> PRT
      <213> Homo sapiens


      <400> 1799
 Met Ile Arg Cys Gly Leu Ala Cys Glu Arg Cys Arg Trp Ile Leu Pro
   1               5                  10                  15    
 Leu Leu Leu Leu Ser Ala Ile Ala Phe Asp Ile Ile Ala Leu Ala Gly
              20                  25                  30        
 Arg Gly Trp Leu Gln Ser Ser Asp His Gly Gln Thr Ser Ser Leu Trp
          35                  40                  45            
 Trp Lys Cys Ser Gln Glu Gly Gly Gly Ser Gly Ser Tyr Glu Glu Gly
      50                  55                  60                
 Cys Gln Ser Leu Met Glu Tyr Asp Phe Cys Cys Ser Lys Cys Arg Lys
  65                  70                  75                  80
 Pro Gly Gln Gln Asn Tyr Leu Gly Gly Cys Trp Thr Ser Ser Val Ser
                  85                  90                  95    
 Cys Trp Pro Lys Asp Arg Asn Arg His Phe Asn Tyr Phe Pro Glu Glu
             100                 105                 110        
 Ser Leu Met Asn Leu Glu Glu Asp Leu Glu Gly Ala Trp Glu Leu Glu
         115                 120                 125            
 Lys Gly Met Trp Ser Leu Ser Ser Ala Trp Gly Arg Ala Ala Ala Ala
     130                 135                 140                
 Met Leu Phe Cys Gly Phe Ile Ile Leu Val Ile Cys Phe Ile Leu Ser
 145                 150                 155                 160
 Phe Phe Ala Leu Cys Gly Pro Gln Met Leu Val Phe Leu Arg Val Ile
                 165                 170                 175    
 Gly Gly Leu Leu Ala Leu Ala Val Pro Ile Arg Val Thr Gly Ile Val
             180                 185                 190        
 Thr Leu His Ala Pro Ile Ser Leu Arg Gly Pro Tyr Pro Leu Thr Pro
         195                 200                 205            
 Leu Pro Glu Lys Leu Gly Tyr Val Ser Pro Gly Lys Ala Val Leu Ser
     210                 215                 220                
 Val Val Val Pro Ser Pro Gly Leu Leu
 225                 230            



      <210> 1800
      <211> 350
      <212> PRT
      <213> Homo sapiens


      <400> 1800
 Met Arg Arg Leu Leu Ser Lys Ala Val Val Ile Asp Asp Asp Asp Asp
   1               5                  10                  15    
 Asp Glu Tyr Pro Trp Arg Gln Asn Ala His Arg Tyr Tyr Ile His Leu
              20                  25                  30        
 Leu Leu Ser Leu Phe Leu Phe Leu Trp Phe Ile Leu Gly Asn Tyr Trp
          35                  40                  45            
 Val Phe Ser Val Tyr Leu Pro Asp Phe Leu Pro Pro Phe Gln Gln Pro
      50                  55                  60                
 Gln Asp Tyr Cys Asp Lys Thr Leu Tyr Leu Phe Ala Val Gly Val Leu
  65                  70                  75                  80
 Ala Leu Ser His Thr Val Leu Val Leu Leu Leu Leu Cys Ser Gly Cys
                  85                  90                  95    
 Val Tyr Leu Cys Ser Arg Glu Gly Val Lys His Val Ala Ser Gly Pro
             100                 105                 110        
 Arg Pro Ser Gly Trp Asp Pro Gly Ser Ala Pro Phe Gln Met Arg Val
         115                 120                 125            
 Ile Leu Asp Val Pro Leu Lys Leu Ser Val Pro Arg Phe His Cys Val
     130                 135                 140                
 Val Trp Phe Ala Lys Gly Leu Arg Glu Tyr Thr Lys Ser Gly Tyr Glu
 145                 150                 155                 160
 Ser Ala Cys Lys Asp Phe Val Pro His Asp Leu Glu Val Gln Ile Pro
                 165                 170                 175    
 Gly Arg Val Phe Leu Val Thr Gly Gly Asn Ser Gly Ile Gly Lys Ala
             180                 185                 190        
 Thr Ala Leu Glu Ile Ala Lys Arg Asp Gly Phe Ile Glu Phe His Gln
         195                 200                 205            
 Val Ala Gln Phe Thr Trp Phe Val Glu Ile Lys Pro Gln Gln Lys Met
     210                 215                 220                
 Pro Gly Val Phe Trp Pro Arg Ser Thr Gly Pro Lys Ser Lys Ser Ser
 225                 230                 235                 240
 Cys Gly Pro Gly Pro Tyr Leu Ile Thr Trp Leu Gly Phe Gly Val Tyr
                 245                 250                 255    
 Ile Leu Thr Thr Gly Leu Ile Pro Val Leu Glu Lys Glu His Asp Pro
             260                 265                 270        
 Arg Val Ile Thr Val Ser Ser Gly Gly Met Leu Val Gln Lys Leu Asn
         275                 280                 285            
 Thr Asn Asp Leu Gln Ser Glu Arg Thr Pro Phe Asp Gly Thr Met Val
     290                 295                 300                
 Tyr Ala Gln Asn Lys Lys Val Asp Phe Tyr Arg Trp Ser Ile Leu His
 305                 310                 315                 320
 Leu Lys Ile Pro Asn Pro Lys Cys Ser Lys Ile Gln Ile Ile Leu Ser
                 325                 330                 335    
 Ala Asp Asp Val Thr Ser Gly Lys Ser His Thr Phe Ala Phe
             340                 345                 350



      <210> 1801
      <211> 613
      <212> PRT
      <213> Homo sapiens


      <400> 1801
 Met Asp Leu Gly Arg Asp Ala Thr Arg Arg Phe Phe Asn Trp Phe Tyr
   1               5                  10                  15    
 Trp Ser Ile Asn Leu Gly Ala Val Leu Ser Leu Leu Val Val Ala Phe
              20                  25                  30        
 Ile Gln Gln Asn Ile Ser Phe Leu Leu Gly Tyr Ser Ile Pro Val Gly
          35                  40                  45            
 Cys Val Gly Leu Ala Phe Phe Ile Phe Leu Phe Ala Thr Pro Val Phe
      50                  55                  60                
 Ile Thr Lys Pro Pro Met Gly Ser Gln Val Ser Ser Met Leu Lys Leu
  65                  70                  75                  80
 Ala Leu Gln Asn Cys Cys Pro Gln Leu Trp Gln Arg His Ser Ala Arg
                  85                  90                  95    
 Lys Cys Glu Asp Asp Gln Gly Leu Asp Ser Glu Asp Gly Ser Lys Asp
             100                 105                 110        
 Lys Asp Asp Gly Val Gly Ile Tyr Thr Glu Asp Thr Asn Ile Gly Asn
         115                 120                 125            
 Ala Asp Asp Ser Gly Ile Lys Gly Glu Asp Asp Gly Asp Asp Val Ser
     130                 135                 140                
 Asn Glu Gly Phe Leu Ser Asp Trp Ala Gln Ser Gly Arg Ser Ala Ser
 145                 150                 155                 160
 Arg Asp Gly Ala Gly Val Ala Val Ile Trp Asp Leu Glu Arg Ala Arg
                 165                 170                 175    
 Thr Ser Glu Ser Ala His Leu His Gly Trp Gln Ser Met Trp Ala Val
             180                 185                 190        
 Gly Cys Glu Leu Arg Trp Asp Cys Val Asp Gln Ser Thr Leu Val Pro
         195                 200                 205            
 Ile Arg Val Val Leu Pro Cys Gly Leu Asn Phe Ser Gln Arg Arg Val
     210                 215                 220                
 Lys Leu Ser Gln Gly Gln Gln Gly Asn Asn Gly Ser Glu Ser Lys Leu
 225                 230                 235                 240
 His Leu Leu Val Ala Lys Trp Gln His Thr Leu Gly Arg Val Glu Leu
                 245                 250                 255    
 Thr Val Ala Val Phe Gly Asp Asp Tyr Thr Asn Ile Val Pro Phe Gly
             260                 265                 270        
 Ile Ser Lys Asp Ser Ala Arg Leu Leu Asp Lys Lys Arg Asp Arg Gln
         275                 280                 285            
 Cys Ala Arg Val Leu Ala Asp Glu Arg Ser Pro Gln Pro Gly Ala Ser
     290                 295                 300                
 Pro Gln Glu Asp Ile Ala Asn Phe Gln Val Leu Val Lys Ile Leu Pro
 305                 310                 315                 320
 Val Met Val Thr Leu Val Pro Tyr Trp Met Val Tyr Phe Gln Met Gln
                 325                 330                 335    
 Ser Thr Tyr Val Leu Gln Gly Leu His Leu His Ile Pro Asn Ile Phe
             340                 345                 350        
 Pro Ala Asn Pro Ala Asn Ile Ser Val Ala Leu Arg Ala Gln Gly Ser
         355                 360                 365            
 Ser Tyr Thr Ile Pro Glu Ala Trp Leu Leu Leu Ala Asn Val Val Val
     370                 375                 380                
 Val Leu Ile Leu Val Pro Leu Lys Asp Arg Leu Ile Asp Pro Leu Leu
 385                 390                 395                 400
 Leu Arg Cys Lys Leu Leu Pro Ser Ala Leu Gln Lys Met Ala Leu Gly
                 405                 410                 415    
 Met Phe Phe Gly Phe Thr Ser Val Ile Val Ala Gly Val Leu Glu Met
             420                 425                 430        
 Glu Arg Leu His Tyr Ile His His Asn Glu Thr Val Ser Gln Gln Ile
         435                 440                 445            
 Gly Glu Val Leu Tyr Asn Ala Ala Pro Leu Ser Ile Trp Trp Gln Ile
     450                 455                 460                
 Pro Gln Tyr Leu Leu Ile Gly Ile Ser Glu Ile Phe Ala Ser Ile Pro
 465                 470                 475                 480
 Gly Leu Glu Phe Ala Tyr Ser Glu Ala Pro Arg Ser Met Gln Gly Ala
                 485                 490                 495    
 Ile Met Gly Ile Phe Phe Cys Leu Ser Gly Val Gly Ser Leu Leu Gly
             500                 505                 510        
 Ser Ser Leu Val Ala Leu Leu Ser Leu Pro Gly Gly Trp Leu His Cys
         515                 520                 525            
 Pro Lys Asp Phe Val Ala Ser Pro Ser Ala Ser Asp Thr Ala Gly Thr
     530                 535                 540                
 Gly Arg Lys Thr Glu Asp Pro Cys Thr Asp Pro Asn Leu Thr Pro Pro
 545                 550                 555                 560
 Phe Pro Arg Asn Ile Asn Asn Cys Arg Met Asp Leu Tyr Phe Phe Leu
                 565                 570                 575    
 Leu Ala Gly Ile Gln Ala Val Thr Ala Leu Leu Phe Val Trp Ile Ala
             580                 585                 590        
 Gly Arg Tyr Glu Arg Ala Ser Gln Gly Pro Ala Ser His Ser Arg Phe
         595                 600                 605            
 Ser Arg Asp Arg Gly
     610            



      <210> 1802
      <211> 1053
      <212> PRT
      <213> Homo sapiens


      <400> 1802
 Met Trp Ala Gly Leu Leu Leu Arg Ala Ala Cys Val Ala Leu Leu Leu
   1               5                  10                  15    
 Pro Gly Ala Pro Ala Arg Gly Tyr Thr Gly Arg Lys Pro Pro Gly His
              20                  25                  30        
 Phe Ala Ala Glu Ser Arg Gly Cys Pro His Cys Val Trp Gln Leu Pro
          35                  40                  45            
 Ile Leu Leu Ser Cys Cys His Lys Met Ala Gly Leu Ala Thr Glu Val
      50                  55                  60                
 Glu Pro Asp Leu Arg Arg Lys Arg Lys Glu Leu Gln Leu Trp His Leu
  65                  70                  75                  80
 Gln Thr Pro Glu Ser Asp Leu Arg Lys Leu Ala Ala Gly Thr Ala Ile
                  85                  90                  95    
 Glu His Ser Leu Thr Phe Pro Phe Ser Glu Leu Pro Lys Pro Met Pro
             100                 105                 110        
 Arg Ala Ala Ile Pro Ser Leu Gln Leu Thr Leu Ala Ala Val Ala Val
         115                 120                 125            
 Gly Arg Gln Leu His Ala Arg Pro Thr Leu Ala His Lys Pro Thr Phe
     130                 135                 140                
 Cys Val His Thr Val Ala Leu Ala Gly Gly Gly Tyr Thr Phe Val Asn
 145                 150                 155                 160
 Val Trp Lys Asp Arg Lys His Val Phe Thr Gln Trp Ser Ser Gln Glu
                 165                 170                 175    
 Glu Leu Thr His Leu Gln Gln Thr Pro Pro Tyr Thr Tyr Ser Ser Ser
             180                 185                 190        
 Ser Ser Pro Lys His Asn Asn Pro Pro Ser Ser Pro Pro His Asn Thr
         195                 200                 205            
 Ile Leu Leu Ile Ser Pro Pro His Leu His Arg Pro Leu Leu Lys Gly
     210                 215                 220                
 Phe Ala Val Ile His Val Ser Pro Arg Leu Val Thr Thr Arg Leu Gly
 225                 230                 235                 240
 Pro His Tyr Ile Ala Leu His Cys Glu Met Phe Ala Pro Lys Val Gly
                 245                 250                 255    
 Leu Ser Val Leu Met Val Ser Gly Asn Asn Ser Asp Gly Ala His Cys
             260                 265                 270        
 Met Gly Pro Gly Leu Arg Gly Lys Glu Thr Thr Leu Val Thr Pro Gln
         275                 280                 285            
 Asp Ser Pro Gly Lys Cys Pro Ile Asn Gly Arg Ser Glu Glu Ala Thr
     290                 295                 300                
 Ala Asp Gly His Thr Asn Gly Arg Thr Lys Lys Phe Met Ser Ser Pro
 305                 310                 315                 320
 Leu Thr Phe His Ser Asp Asp Lys Ser Gly Ser Val Val Ile Phe Gly
                 325                 330                 335    
 Gly Ile Asp Ser Ser Tyr Tyr Thr Gly Ser Leu Asn Trp Val Pro Val
             340                 345                 350        
 Thr Val Glu Gly Tyr Trp Gln Ile Thr Val Asp Ser Ile Thr Met Asn
         355                 360                 365            
 Gly Glu Thr Ile Ala Cys Ala Glu Gly Cys Gln Ala Ile Val Asp Thr
     370                 375                 380                
 Gly Thr Ser Leu Leu Thr Gly Pro Thr Ser Pro Ile Ala Asn Ile Gln
 385                 390                 395                 400
 Ser Asp Ile Gly Ala Ser Glu Asn Ser Asp Gly Asp Met Val Val Ser
                 405                 410                 415    
 Cys Ser Ala Ile Ser Ser Leu Pro Asp Ile Val Phe Thr Ile Asn Gly
             420                 425                 430        
 Val Gln Tyr Pro Val Pro Pro Ser Ala Tyr Ile Leu Gln Leu Trp Ile
         435                 440                 445            
 Leu Gly Asp Val Phe Ile Arg Gln Tyr Phe Thr Ser Ser Thr Val His
     450                 455                 460                
 Thr Thr Arg Ser Ala Trp Arg Val Trp Phe Lys His Thr Asp Glu Cys
 465                 470                 475                 480
 Leu Gly Thr Pro Cys Gln Gln Arg Cys Lys Asn Ser Ile Gly Ser Tyr
                 485                 490                 495    
 Lys Cys Ser Cys Arg Thr Gly Phe His Leu His Gly Asn Arg His Ser
             500                 505                 510        
 Cys Val Glu Lys Val Pro Lys Cys Phe Glu Leu Arg Asp Gly Arg Lys
         515                 520                 525            
 Lys Gly Ser Val Ala Gln Thr Lys Gln Leu Ser Ala Ala Arg Thr Ser
     530                 535                 540                
 Arg Arg Arg Lys Arg Val Ser Asp Ala Ile Gly Asp Ala Ser Leu Ser
 545                 550                 555                 560
 Pro Phe Leu Pro Gln His Arg Gly Gln Leu Arg Met His Met Arg Thr
                 565                 570                 575    
 Trp Phe Gln Asp Gly Lys Val Thr Cys Glu Lys Ala Ser Glu Gly Lys
             580                 585                 590        
 Arg Val Thr Ser Phe Val Asn Phe Phe Ala Ala Cys Asp Ala Arg Val
         595                 600                 605            
 Thr Asp Ser Tyr Ser Glu Asp His Ser Pro Leu Val Met Lys Trp Val
     610                 615                 620                
 Leu Phe Leu Asp Ile Lys Ala Asp Leu Cys Phe Thr Trp Ile Asp Leu
 625                 630                 635                 640
 Ser Ser Gly Ser Glu Val Gln Val Leu Leu Leu Pro Pro Leu Tyr Ser
                 645                 650                 655    
 Asp Pro Gly Ser Thr Gly Leu Ser Ile Phe Gln Gln Leu Ser Ala Arg
             660                 665                 670        
 Cys Glu Leu Ser Leu Phe Gln Ser Leu His Thr Met Thr Ser Lys Lys
         675                 680                 685            
 Leu Val Asn Ser Val Ala Gly Cys Ala Asp Asp Ala Leu Ala Gly Leu
     690                 695                 700                
 Val Ala Cys Asn Pro Asn Leu Gln Leu Leu Gln Gly His Arg Val Ala
 705                 710                 715                 720
 Leu Arg Ser Asp Leu Asp Ser Leu Lys Gly Arg Val Ala Leu Leu Ser
                 725                 730                 735    
 Gly Gly Gly Ser Gly His Glu Pro Ala His Ala Ala Lys Ser Ile His
             740                 745                 750        
 Leu Ala Asn Thr His Glu Pro Thr Val Tyr Leu Ala Leu Tyr Trp Ala
         755                 760                 765            
 Leu Gly Ile Pro Asp Arg Gln Gly Phe Ile Gly Lys Gly Met Leu Thr
     770                 775                 780                
 Gly Val Ile Ala Gly Ala Val Phe Thr Ser Pro Ala Val Gly Ser Ile
 785                 790                 795                 800
 Leu Ala Ala Ile Thr Ala Val Ala Gln Pro Pro Thr Arg Lys Arg Arg
                 805                 810                 815    
 Met His His Gly Ile Gly Gly Ala Ser Gly Gly Ser Thr Pro Val Gly
             820                 825                 830        
 Pro Asn Ala Arg Ser Asp Gly Thr Ser Pro Val Ala Ala Ala Leu Arg
         835                 840                 845            
 Gln Thr Pro Arg Gly Leu Arg Trp Gly Gln Ser Ala Val Arg Arg Gly
     850                 855                 860                
 Val Tyr Arg Val Leu Ser Gly Val Val Pro Phe Thr Val Arg Gly Ala
 865                 870                 875                 880
 Pro Ala Gly Cys Cys Ser Pro Gly Gly Val Leu Leu Gly Ser Gln Thr
                 885                 890                 895    
 Arg Val Thr Glu Thr Pro Arg Trp Thr Val Lys Thr Met Val Asn Thr
             900                 905                 910        
 Ala Glu Lys Pro Ser Leu Thr Asn Pro Ile Pro Leu Gly Cys Val Val
         915                 920                 925            
 Ala Thr Val Ser Ala Thr Leu Ser Cys Lys Cys Phe Asp Ile Val Leu
     930                 935                 940                
 Trp Leu Phe Leu Gly Ser Val Cys Leu Cys Asn Glu Lys Tyr Val Gln
 945                 950                 955                 960
 Lys Met Ser Gln Ala Leu Cys Ser Phe Gly Cys Gly Ser Gly Ile Cys
                 965                 970                 975    
 Ile Ala Pro Asn Val Cys Ser Cys Gln Asp Gly Glu Gln Gly Ala Thr
             980                 985                 990        
 Cys Pro Glu Thr His Gly Pro Cys Gly Glu Tyr Gly Cys Asp Leu Thr
         995                1000                1005            
 Cys Asn His Gly Gly Cys Gln Glu Val Ala Arg Val Cys Pro Val Gly
    1010                1015                1020                
 Phe Ser Met Thr Glu Thr Ala Val Gly Ile Arg Cys Thr Gly Trp Ser
1025                1030                1035                1040
 Pro Val Tyr Cys Lys Ala Lys Leu Ser Gln Asp Arg Leu
                1045                1050            



      <210> 1803
      <211> 312
      <212> PRT
      <213> Homo sapiens


      <400> 1803
 Met Ala Ser Leu Gly Leu Gln Leu Val Gly Tyr Ile Leu Gly Leu Leu
   1               5                  10                  15    
 Gly Leu Leu Gly Thr Leu Val Ala Met Leu Leu Pro Ser Trp Lys Thr
              20                  25                  30        
 Ser Ser Tyr Val Gly Ala Ser Ile Val Thr Ala Val Gly Phe Ser Lys
          35                  40                  45            
 Gly Leu Trp Met Glu Cys Ala Thr His Ser Thr Gly Ile Thr Gln Cys
      50                  55                  60                
 Asp Ile Tyr Ser Thr Leu Leu Gly Leu Pro Ala Asp Ile Gln Ala Ala
  65                  70                  75                  80
 Gln Ala Met Met Val Thr Ser Ser Ala Ile Ser Ser Leu Ala Cys Ile
                  85                  90                  95    
 Ile Ser Val Val Gly Met Arg Cys Thr Val Phe Cys Gln Glu Ser Arg
             100                 105                 110        
 Ala Lys Asp Arg Val Ala Val Ala Gly Gly Val Phe Phe Ile Leu Gly
         115                 120                 125            
 Gly Leu Leu Gly Phe Ile Pro Val Ala Trp Asn Leu His Gly Ile Leu
     130                 135                 140                
 Arg Asp Phe Tyr Ser Pro Leu Val Pro Asp Ser Met Lys Phe Glu Ile
 145                 150                 155                 160
 Gly Glu Ala Leu Tyr Leu Gly Ile Ile Ser Ser Leu Phe Ser Leu Ile
                 165                 170                 175    
 Ala Gly Ile Ile Leu Cys Phe Ser Cys Ser Ser Gln Arg Asn Arg Ser
             180                 185                 190        
 Asn Tyr Tyr Asp Ala Tyr Gln Ala Gln Pro Leu Ala Thr Arg Ser Ser
         195                 200                 205            
 Pro Arg Pro Gly Gln Pro Pro Lys Val Lys Thr Leu Val Thr His Cys
     210                 215                 220                
 Tyr Val Ile Ile Asn Gly Arg Arg Arg Thr Glu Thr Gly Phe Leu Val
 225                 230                 235                 240
 Glu Arg Gln Ala Pro Thr Phe Gly Lys Thr Phe Val Gln Pro Phe Lys
                 245                 250                 255    
 Gln Leu Ser Ala Gly Gln Pro Thr Leu Thr Glu Leu Leu Leu Cys Val
             260                 265                 270        
 Arg Lys Cys Ala Lys Gly Phe Glu Gly Asp Glu Ser Glu Gln Gly Phe
         275                 280                 285            
 Gln Gly Leu Ser Gly Arg Ser Asp Leu Leu Glu His Phe Pro Glu Pro
     290                 295                 300                
 Leu Ser Lys Val Ile Leu Pro Ala
 305                 310        



      <210> 1804
      <211> 278
      <212> PRT
      <213> Homo sapiens


      <400> 1804
 Met Thr Thr Arg Gly Gly Tyr Thr Ala Pro Arg Gly Trp Val Pro Ala
   1               5                  10                  15    
 Phe Ser Leu Phe Leu Gly Val His Pro Leu Pro Ile Pro Gly Gly Ile
              20                  25                  30        
 Asp Thr Gln Gly Ser Pro Leu Ile Phe Ile Tyr Glu Thr Phe Tyr Lys
          35                  40                  45            
 Leu Tyr Lys Val Glu Val Gln Arg Gly Leu Gly Gly Gly Arg Asp Gly
      50                  55                  60                
 Gly Gly His Cys Pro Gly Glu Asp Ser Met Gly Gly Gly Gly Met Glu
  65                  70                  75                  80
 Asn His Pro His Ala Arg Asp Leu Leu His Ser Leu Leu Pro Ala Gln
                  85                  90                  95    
 Val Gln Glu Gln Pro Leu Pro Ser Pro Cys Arg Leu Ile Val Ser Gln
             100                 105                 110        
 Lys Ala Arg Arg Leu Leu Lys Gly Ser Gly Phe His Leu Asp Leu Leu
         115                 120                 125            
 Leu Ile Gly Ser Leu Gly Gly Leu Cys Gly Leu Phe Gly Leu Pro Trp
     130                 135                 140                
 Leu Thr Ala Ala Thr Val Arg Ser Val Thr His Val Asn Ala Leu Thr
 145                 150                 155                 160
 Val Met Arg Thr Ala Ile Ala Pro Pro Pro Gly Leu Ser Ile Val Met
                 165                 170                 175    
 Gly Ala Val Leu Arg Arg Ile Pro Leu Ala Val Leu Phe Gly Ile Phe
             180                 185                 190        
 Leu Tyr Met Gly Val Thr Ser Leu Ser Gly Ile Gln Leu Ser Gln Arg
         195                 200                 205            
 Leu Leu Leu Ile Leu Met Pro Ala Lys His His Pro Glu Gln Pro Tyr
     210                 215                 220                
 Val Thr Lys Val Gly Pro Gly Ser Met Gly Val Gly Gln Trp Gly Asp
 225                 230                 235                 240
 Gly Lys Gly Ile Gln Arg Asp Leu Leu Phe Pro Leu Gln Leu Asp Ser
                 245                 250                 255    
 Glu Asp Ala Glu Pro Asn Phe Asp Glu Asp Gly Gln Asp Glu Tyr Asn
             260                 265                 270        
 Glu Leu His Met Pro Val
         275            



      <210> 1805
      <211> 1638
      <212> PRT
      <213> Homo sapiens


      <400> 1805
 Met Leu Arg Ala Gly Trp Leu Arg Gly Ala Ala Ala Leu Ala Leu Leu
   1               5                  10                  15    
 Leu Ala Ala Arg Val Val Ala Ala Phe Glu Pro Ile Thr Val Gly Leu
              20                  25                  30        
 Ala Ile Gly Ala Ala Ser Ala Ile Thr Gly Tyr Leu Ser Tyr Asn Asp
          35                  40                  45            
 Ile Tyr Cys Arg Phe Ala Glu Cys Cys Arg Glu Glu Arg Pro Leu Asn
      50                  55                  60                
 Ala Ser Ala Leu Lys Leu Asp Leu Glu Glu Lys Leu Phe Gly Gln His
  65                  70                  75                  80
 Leu Ala Thr Glu Val Ile Phe Lys Ala Leu Thr Gly Phe Arg Asn Asn
                  85                  90                  95    
 Lys Asn Pro Lys Lys Pro Leu Thr Leu Ser Leu His Gly Trp Ala Gly
             100                 105                 110        
 Thr Gly Lys Asn Phe Val Ser Gln Ile Val Ala Glu Asn Leu His Pro
         115                 120                 125            
 Lys Gly Leu Lys Ser Asn Phe Val His Leu Phe Asp Gln Leu Gln Lys
     130                 135                 140                
 Trp Ile Arg Gly Asn Val Ser Ala Cys Ala Asn Ser Val Phe Ile Phe
 145                 150                 155                 160
 Asp Glu Met Asp Lys Leu His Pro Gly Ile Ile Asp Ala Ile Lys Pro
                 165                 170                 175    
 Phe Leu Asp Tyr Tyr Glu Gln Val Asp Gly Val Ser Tyr Arg Lys Ala
             180                 185                 190        
 Ile Phe Ile Phe Leu Ser Asn Ala Gly Gly Asp Leu Ile Thr Lys Thr
         195                 200                 205            
 Ala Leu Asp Phe Trp Arg Ala Gly Arg Lys Arg Glu Asp Ile Gln Leu
     210                 215                 220                
 Lys Asp Leu Glu Pro Val Leu Ser Val Gly Val Phe Asn Asn Lys His
 225                 230                 235                 240
 Thr Ala Asn Thr Ala Leu Ala Val Glu Ser Phe Thr Val Ser Ala Gly
                 245                 250                 255    
 Ile Ser Pro Ser Leu Pro Cys Ala Ile Ser Gln Leu Gly Ser Leu Leu
             260                 265                 270        
 Glu Ser Pro Gln Pro Tyr Ile Ile Glu Leu Asn His Asn Glu Thr Val
         275                 280                 285            
 Gly Phe Glu Phe Glu Ser Leu Val Pro Met Gly Arg Lys Gln Ser Gln
     290                 295                 300                
 Met Val Leu Gly Val Ala Asn Ala Thr Gln Gln Asn Gly His Gly Glu
 305                 310                 315                 320
 Arg Glu Val Glu Gln Ala Gly Gln Asp Leu Arg Ala Glu Pro Glu Gln
                 325                 330                 335    
 Gln Gly Pro Ser His Ala Asp Pro Gly Val Thr Ala Glu Gln Gly Ala
             340                 345                 350        
 Gly Leu Gly Thr Arg Trp Asp Trp Arg Trp Met Ala Leu Leu Thr Val
         355                 360                 365            
 Leu Val Ile Glu Asn Arg His Arg Gln Arg Val Phe Asn Val Phe Glu
     370                 375                 380                
 Leu Asp Val Phe Pro Leu Leu Ser Thr Pro Pro Glu Ile Gln Ser His
 385                 390                 395                 400
 Ile Cys Asp Pro Phe Cys Ser Ser Ile Ala Ala Lys Gln Ser Gln Trp
                 405                 410                 415    
 Val Asp Ile Val Thr Val Gln Thr Thr Leu Val Asn Ile Leu Cys Asp
             420                 425                 430        
 Asp Leu Ala Asp Glu Ile Phe Ala Gly Ala Cys Pro Pro Val Gln Gly
         435                 440                 445            
 Glu His Glu Lys Thr Glu Ala Lys Ser Glu Lys Asp Leu Ser Lys Asp
     450                 455                 460                
 Thr Ser Ser Lys Leu Arg Asp Trp Phe Ser Gln Thr Gln Met His Val
 465                 470                 475                 480
 His Ser Leu Asp Thr Glu Ser Leu Ser Asp Asp Gly Glu Ala Pro Trp
                 485                 490                 495    
 Glu Leu Leu Gln Glu Ser Arg Gly Ser Thr Ser Ala Ala Leu Thr Leu
             500                 505                 510        
 Ser Glu Val Ala Leu Asn Leu Pro Ile Lys Gln Pro Ile His Gln Gly
         515                 520                 525            
 Phe Trp Arg Leu Asp Val Ser Asp Gln Gly Ala Asp Arg Phe Gly Ser
     530                 535                 540                
 Ser Glu Gly Pro Phe Leu Gly Leu Gln Met Ala Ile Phe Ser Leu Cys
 545                 550                 555                 560
 Pro Gly Leu Val Phe Pro Leu Trp Lys Gln Arg Cys Ser Ala Gly Met
                 565                 570                 575    
 Gly Val Gln Lys Arg Arg Leu Pro Gln Asp Arg Glu Ala Val Glu Gly
             580                 585                 590        
 Phe Ala Leu Val His Glu Val Ala Phe Pro Gly Phe Phe Phe Asp Val
         595                 600                 605            
 Lys Ser Thr Arg Arg Leu Glu Cys Ser Gly Ala Ile Ile Ala His Cys
     610                 615                 620                
 Ser Leu Ile Leu Leu Gly Ser Ser His Pro Pro Ile Thr Ala Ser Arg
 625                 630                 635                 640
 Val Ala Gly Thr Thr Asp Pro Tyr Ser Pro Ser Leu Ser Ala Val Asn
                 645                 650                 655    
 Lys Gly Cys Glu Cys Trp Pro Leu Pro Val Gly Phe Val Ser Pro Arg
             660                 665                 670        
 Gly Glu Val Thr Lys Glu Asp Leu Leu Leu Lys Ser Lys Val Ala Cys
         675                 680                 685            
 Pro Tyr Val Gly Cys Gly Glu Ser Phe Ala Asp His Ser Thr Ile His
     690                 695                 700                
 Ala Gln Ala Lys Lys His Asn Leu Thr Val Asn Leu Thr Thr Phe Arg
 705                 710                 715                 720
 Leu Trp Cys Tyr Ala Cys Glu Lys Glu Val Phe Leu Glu Gln Arg Leu
                 725                 730                 735    
 Ala Ala Pro Leu Leu Gly Ser Ser Ser Lys Phe Ser Glu Gln Asp Ser
             740                 745                 750        
 Pro Pro Pro Ser His Pro Leu Lys Ala Val Pro Ile Ala Val Ala Asp
         755                 760                 765            
 Glu Gly Glu Ser Glu Ser Glu Asp Asp Asp Leu Lys Pro Arg Gly Leu
     770                 775                 780                
 Thr Gly Met Lys Asn Leu Gly Asn Ser Cys Tyr Met Asn Ala Ala Leu
 785                 790                 795                 800
 Gln Ala Leu Ser Asn Cys Lys Cys Arg Lys Asn Gly Thr Arg Gln His
                 805                 810                 815    
 Ala Leu Lys Gln Glu Gly Val Gln Asn Leu Phe Phe Leu Glu Cys Gly
             820                 825                 830        
 Gly Leu Val Arg Thr Asp Lys Lys Pro Ala Leu Cys Lys Ser Tyr Gln
         835                 840                 845            
 Lys Leu Val Ser Glu Val Trp His Lys Lys Arg Pro Ser Tyr Val Val
     850                 855                 860                
 Pro Thr Ser Leu Ser His Gly Ile Lys Leu Val Asn Pro Met Phe Arg
 865                 870                 875                 880
 Gly Tyr Ala Gln Gln Asp Thr Gln Glu Phe Leu Arg Cys Leu Met Asp
                 885                 890                 895    
 Gln Leu His Glu Glu Leu Lys Glu Pro Val Val Ala Thr Val Ala Leu
             900                 905                 910        
 Thr Glu Ala Arg Asp Ser Asp Ser Ser Asp Thr Asp Glu Lys Arg Glu
         915                 920                 925            
 Gly Asp Arg Ser Pro Ser Glu Asp Glu Phe Leu Ser Cys Asp Ser Ser
     930                 935                 940                
 Ser Asp Arg Gly Glu Gly Asp Gly Gln Gly Arg Gly Gly Gly Ser Ser
 945                 950                 955                 960
 Gln Ala Glu Thr Glu Leu Leu Ile Pro Asp Glu Ala Gly Arg Ala Ile
                 965                 970                 975    
 Ser Glu Lys Glu Arg Met Lys Asp Arg Lys Phe Ser Trp Gly Gln Gln
             980                 985                 990        
 Arg Thr Asn Ser Glu Gln Val Asp Glu Asp Ala Asp Val Asp Thr Ala
         995                1000                1005            
 Met Ala Ala Leu Asp Asp Gln Pro Ala Glu Ala Gln Pro Pro Ser Pro
    1010                1015                1020                
 Arg Ser Ser Ser Pro Cys Arg Thr Pro Glu Pro Asp Asn Asp Ala His
1025                1030                1035                1040
 Leu Arg Ser Ser Ser Arg Pro Cys Ser Pro Val His His His Glu Gly
                1045                1050                1055    
 His Ala Lys Leu Ser Ser Ser Pro Pro Arg Ala Ser Pro Val Arg Met
            1060                1065                1070        
 Ala Pro Ser Tyr Val Leu Lys Lys Ala Gln Val Leu Ser Ala Gly Ser
        1075                1080                1085            
 Arg Arg Arg Lys Glu Gln Arg Tyr Arg Ser Val Ile Ser Asp Ile Phe
    1090                1095                1100                
 Asp Gly Ser Ile Leu Ser Leu Val Gln Cys Leu Thr Cys Asp Arg Val
1105                1110                1115                1120
 Ser Thr Thr Val Glu Thr Phe Gln Asp Leu Ser Leu Pro Ile Pro Gly
                1125                1130                1135    
 Lys Glu Asp Leu Ala Lys Leu His Ser Ala Ile Tyr Gln Asn Val Pro
            1140                1145                1150        
 Ala Lys Pro Gly Ala Cys Gly Asp Ser Tyr Ala Ala Gln Gly Trp Leu
        1155                1160                1165            
 Ala Phe Ile Val Glu Tyr Ile Arg Arg Phe Val Val Ser Cys Thr Pro
    1170                1175                1180                
 Ser Trp Phe Trp Gly Pro Val Val Thr Leu Glu Asp Cys Leu Ala Ala
1185                1190                1195                1200
 Phe Phe Ala Ala Asp Glu Leu Lys Gly Asp Asn Met Tyr Ser Cys Glu
                1205                1210                1215    
 Arg Cys Lys Lys Leu Arg Asn Gly Val Lys Tyr Cys Lys Val Leu Arg
            1220                1225                1230        
 Leu Pro Glu Ile Leu Cys Ile His Leu Lys Arg Phe Arg His Glu Val
        1235                1240                1245            
 Met Tyr Ser Phe Lys Ile Asn Ser His Val Ser Phe Pro Leu Glu Gly
    1250                1255                1260                
 Leu Asp Leu Arg Pro Phe Leu Ala Lys Glu Cys Thr Ser Gln Ile Thr
1265                1270                1275                1280
 Thr Tyr Asp Leu Leu Ser Val Ile Cys His His Gly Thr Ala Gly Ser
                1285                1290                1295    
 Gly His Tyr Ile Ala Tyr Cys Gln Asn Val Ile Asn Gly Gln Trp Tyr
            1300                1305                1310        
 Glu Phe Asp Asp Gln Tyr Val Thr Glu Val His Glu Thr Val Val Gln
        1315                1320                1325            
 Asn Ala Glu Gly Tyr Val Leu Phe Tyr Arg Lys Ser Ser Glu Glu Ala
    1330                1335                1340                
 Met Arg Glu Arg Gln Gln Val Val Ser Leu Ala Ala Met Arg Glu Pro
1345                1350                1355                1360
 Ser Leu Leu Arg Phe Tyr Val Ser Arg Glu Trp Leu Asn Lys Phe Asn
                1365                1370                1375    
 Thr Phe Ala Glu Pro Gly Pro Ile Thr Asn Gln Thr Phe Leu Cys Ser
            1380                1385                1390        
 His Gly Gly Ile Pro Pro His Lys Tyr His Tyr Ile Asp Asp Leu Val
        1395                1400                1405            
 Val Ile Leu Pro Gln Asn Val Trp Glu His Leu Tyr Asn Arg Phe Gly
    1410                1415                1420                
 Gly Gly Pro Ala Val Asn His Leu Tyr Val Cys Ser Ile Cys Gln Val
1425                1430                1435                1440
 Glu Ile Glu Ala Leu Ala Lys Arg Arg Arg Ile Glu Ile Asp Thr Phe
                1445                1450                1455    
 Ile Lys Leu Asn Lys Ala Phe Gln Ala Glu Glu Ser Pro Gly Val Ile
            1460                1465                1470        
 Tyr Cys Ile Ser Met Gln Trp Phe Arg Glu Trp Glu Ala Phe Val Lys
        1475                1480                1485            
 Gly Lys Asp Asn Glu Pro Pro Gly Pro Ile Asp Asn Ser Arg Ile Ala
    1490                1495                1500                
 Gln Val Lys Gly Ser Gly His Val Gln Leu Lys Gln Gly Ala Asp Tyr
1505                1510                1515                1520
 Gly Gln Ile Ser Glu Glu Thr Trp Thr Tyr Leu Asn Ser Leu Tyr Gly
                1525                1530                1535    
 Gly Gly Pro Glu Ile Ala Ile Arg Gln Ser Val Ala Gln Pro Leu Gly
            1540                1545                1550        
 Pro Glu Asn Leu His Gly Glu Gln Lys Ile Glu Ala Glu Thr Arg Ala
        1555                1560                1565            
 Glu Lys Gly Val Pro Ile Gln Thr Pro Arg Glu Gly Ser Trp Ile Ser
    1570                1575                1580                
 Cys Arg Lys Lys Leu Lys Ala Ser Ala Ser Leu Pro Leu Ser Asp Thr
1585                1590                1595                1600
 Ser Val Gln Lys His Phe Ser Val Cys Lys Asp Asn Thr Val Thr Arg
                1605                1610                1615    
 Asn Gln Asp Asp Thr Leu Pro Val Pro Trp Lys Ala Trp Gly Pro Ser
            1620                1625                1630        
 Gly Val Gly His Leu Ala
        1635            



      <210> 1806
      <211> 538
      <212> PRT
      <213> Homo sapiens


      <400> 1806
 Met Gly Val Pro Trp Arg Leu Ala Pro Leu Gly Gln Gly Leu Ser Thr
   1               5                  10                  15    
 Val Trp Leu Pro Ser Lys Met Ala Leu Val Glu Thr Pro Gln Ser Pro
              20                  25                  30        
 Ser Phe His Ala Pro Gln His Phe Val Ser Val Val Leu Gln Leu Gln
          35                  40                  45            
 Ala Cys Val His Leu Pro Glu Gly Thr Gln Asn Tyr Phe Glu Ser Tyr
      50                  55                  60                
 Leu Ala Val Ala Ser Thr Val Pro Ser Met Leu Cys Leu Val Ala Asn
  65                  70                  75                  80
 Phe Leu Leu Val Asn Arg Val Ala Val His Ile Arg Val Leu Ala Ser
                  85                  90                  95    
 Leu Thr Val Ile Leu Ala Ile Phe Met Val Ile Thr Ala Leu Val Lys
             100                 105                 110        
 Val Asp Thr Ser Ser Trp Thr Arg Gly Phe Phe Ala Val Thr Ile Val
         115                 120                 125            
 Cys Met Val Ile Leu Ser Gly Ala Ser Thr Val Phe Ser Ser Ser Ile
     130                 135                 140                
 Tyr Gly Met Thr Gly Ser Phe Pro Met Arg Asn Ser Gln Ala Leu Ile
 145                 150                 155                 160
 Ser Gly Gly Ala Met Gly Gly Thr Val Ser Ala Val Ala Ser Leu Val
                 165                 170                 175    
 Asp Leu Ala Ala Ser Ser Asp Val Arg Asn Ser Ala Leu Ala Phe Phe
             180                 185                 190        
 Leu Thr Ala Thr Val Phe Leu Val Leu Cys Met Gly Leu Tyr Leu Leu
         195                 200                 205            
 Leu Ser Arg Leu Glu Tyr Ala Arg Tyr Tyr Met Arg Pro Val Leu Ala
     210                 215                 220                
 Ala His Val Phe Ser Gly Glu Glu Glu Leu Pro Gln Asp Ser Leu Ser
 225                 230                 235                 240
 Ala Pro Ser Val Ala Ser Arg Phe Ile Asp Ser His Thr Pro Pro Leu
                 245                 250                 255    
 Arg Pro Ile Leu Lys Lys Thr Ala Ser Leu Gly Phe Cys Val Thr Tyr
             260                 265                 270        
 Val Phe Phe Ile Thr Ser Leu Ile Tyr Pro Ala Val Cys Thr Asn Ile
         275                 280                 285            
 Glu Ser Leu Asn Lys Gly Ser Gly Ser Leu Trp Thr Thr Lys Phe Phe
     290                 295                 300                
 Ile Pro Leu Thr Thr Phe Leu Leu Tyr Asn Phe Ala Asp Leu Cys Gly
 305                 310                 315                 320
 Arg Gln Leu Thr Ala Trp Ile Gln Val Pro Gly Pro Asn Ser Lys Ala
                 325                 330                 335    
 Leu Pro Gly Phe Val Leu Leu Arg Thr Cys Leu Ile Pro Leu Phe Val
             340                 345                 350        
 Leu Cys Asn Tyr Gln Pro Arg Val His Leu Lys Thr Val Val Phe Gln
         355                 360                 365            
 Ser Asp Val Tyr Pro Ala Leu Leu Ser Ser Leu Leu Gly Leu Ser Asn
     370                 375                 380                
 Gly Tyr Leu Ser Thr Leu Ala Leu Leu Tyr Gly Pro Lys Ile Val Pro
 385                 390                 395                 400
 Arg Glu Leu Ala Glu Ala Thr Gly Val Pro Phe Lys Asp Ala Ala Ser
                 405                 410                 415    
 Val Arg Pro Arg Val Ile Thr Lys Pro Val Pro Lys Pro Ser His Gly
             420                 425                 430        
 Leu Phe Ala Thr Ser Gln Leu Arg Ser Phe Gln Leu Thr Ala Arg Cys
         435                 440                 445            
 Lys Gln Met Leu Ser Ser Pro Tyr Pro Glu Gly Val Ser Leu Glu Trp
     450                 455                 460                
 Lys Ser Pro Gly Met Ile His Leu His Pro Ile Leu Trp Asp Lys Glu
 465                 470                 475                 480
 Ser Val Gly Pro Lys Gly His Asp Asn Gln Glu Leu Thr Ala Leu Phe
                 485                 490                 495    
 Pro Ser Ala Met Leu Trp Gly Ala Gly Pro Gln Leu Ala Ala Gly Glu
             500                 505                 510        
 Arg Gln Leu Val Lys Gly Ser Ser Gln Arg Leu His His Phe Glu Leu
         515                 520                 525            
 Gly Pro Phe Trp Cys Arg Thr Trp Ile Pro
     530                 535            



      <210> 1807
      <211> 267
      <212> PRT
      <213> Homo sapiens

      <220>
      <221> misc_feature
      <222> (1)...(267)
      <223> Xaa = any amino acid or nothing 


      <400> 1807
 Met Gly Thr Asn Pro Pro Ala Gly Ser Arg Gly Gly Ile Arg Phe Ser
   1               5                  10                  15    
 His Ser Lys Arg Glu Thr Glu Phe Leu Thr Leu Cys His Ile Arg Met
              20                  25                  30        
 Leu Leu Gly Leu Gly Ser Thr Cys Asn Leu Ala Met Thr Val Cys Phe
          35                  40                  45            
 Phe Ser Asp Val Leu Gly Gly Val Leu Ile Thr Ala Leu Leu Ile Val
      50                  55                  60                
 Leu Thr Tyr Pro Ala Trp Thr Phe Ile Asp Cys Leu Asp Ser Ala Ser
  65                  70                  75                  80
 Pro Leu Phe Pro Val Cys Val Ile Val Val Pro Phe Phe Leu Cys Tyr
                  85                  90                  95    
 Asn Tyr Pro Val Ser Asp Tyr Tyr Ser Pro Thr Arg Ala Asp Thr Thr
             100                 105                 110        
 Thr Ile Leu Ala Ala Gly Ala Gly Val Thr Ile Gly Phe Trp Ile Asn
         115                 120                 125            
 His Phe Phe Gln Leu Val Ser Lys Pro Ala Glu Ser Leu Pro Val Ile
     130                 135                 140                
 Gln Asn Ile Pro Pro Leu Thr Thr Tyr Met Leu Val Leu Gly Leu Thr
 145                 150                 155                 160
 Lys Phe Ala Val Gly Ile Val Leu Ile Leu Leu Val Arg Gln Leu Val
                 165                 170                 175    
 Gln Lys Gly Tyr Ser Xaa Lys Gly Asn Lys Thr Ser Pro Val Phe His
             180                 185                 190        
 Thr Gly Val Lys Leu Thr Gly Glu Ser Arg Leu Ser Asn Tyr Arg Phe
         195                 200                 205            
 Ile Xaa Thr Gln Tyr Pro Phe Val Leu Gly Leu Val Met Ala Val Val
     210                 215                 220                
 Phe Ser Thr Leu Val Cys Leu Ser Arg Leu Tyr Thr Gly Met His Thr
 225                 230                 235                 240
 Val Leu Leu Cys Asp Ser Gly Gln Ile Ile Ser Pro Ser Leu Asn Xaa
                 245                 250                 255    
 Lys Leu Xaa Val Val Arg Val Lys Trp Glu His
             260                 265        



      <210> 1808
      <211> 124
      <212> PRT
      <213> Homo sapiens

      <220>
      <221> misc_feature
      <222> (1)...(124)
      <223> Xaa = any amino acid or nothing 


      <400> 1808
 Met Glu Ser Ala Leu Pro Ala Ala Gly Phe Leu Tyr Trp Val Gly Ala
   1               5                  10                  15    
 Gly Thr Val Ala Tyr Leu Ala Leu Arg Ile Ser Tyr Ser Leu Phe Thr
              20                  25                  30        
 Ala Leu Arg Val Trp Gly Val Gly Asn Glu Xaa Gly Gly Arg Pro Gly
          35                  40                  45            
 Ala Arg Arg Met Gly Arg Leu Leu Cys Pro Ala Gly Pro Ser Trp Leu
      50                  55                  60                
 Pro Trp Leu Ser Ser Ala Cys Leu Asp Tyr Leu Gln Ser Phe Lys Gly
  65                  70                  75                  80
 Leu Ser Asp Gly Val Ile Glu Thr Leu Lys Leu Gly Tyr Cys Val Val
                  85                  90                  95    
 Met Arg Val Leu Asp Phe Leu Ile Phe Ala Asn Tyr Val Ile Val Leu
             100                 105                 110        
 Leu Val Met Lys Leu Gln Ile Arg Asp Gly Lys Phe
         115                 120                



      <210> 1809
      <211> 226
      <212> PRT
      <213> Homo sapiens


      <400> 1809
 Met Arg Asn Leu Arg Leu Lys Glu Leu Pro Lys Trp Phe Lys Met Leu
   1               5                  10                  15    
 Lys Leu Phe Ser Leu Ile Arg Tyr His Val Ser Ile Leu Ala Leu Val
              20                  25                  30        
 Ala Ile Ala Phe Gly Val Phe Val Met Lys Ala Leu Pro Val Pro Asp
          35                  40                  45            
 His Tyr Lys Gln Ile Asn Asn His Thr Ala Lys Met His Glu His Asn
      50                  55                  60                
 Met Lys Leu Val Cys Asp Gln Asn Gly Asp Ile Gly Lys Gln Gly Lys
  65                  70                  75                  80
 Leu Ala Ser Cys Ile Glu Ile Gly Pro Val Thr Ile Thr Thr Asp Pro
                  85                  90                  95    
 Lys Lys Phe Gln Tyr Glu Leu Arg Glu Leu Tyr Val Gln Arg Tyr Gly
             100                 105                 110        
 Ile Asn Gly Gly Gly Asp Cys Pro Glu Met Ser Ile Gly Ala Ile Lys
         115                 120                 125            
 Ile Ala Leu Glu Ile Ser Leu Pro Gly Ser Phe Ile Tyr Val Phe Thr
     130                 135                 140                
 Asp Ala Arg Ser Lys Asp Tyr Arg Leu Thr His Glu Val Leu Gln Leu
 145                 150                 155                 160
 Ile Gln Gln Lys Gln Ser Gln Val Val Phe Val Leu Thr Gly Asp Cys
                 165                 170                 175    
 Asp Asp Arg Thr His Ile Gly Tyr Lys Val Tyr Glu Glu Ile Ala Ser
             180                 185                 190        
 Thr Ser Ser Gly Gln Val Phe His Leu Asp Lys Lys Gln Val Asn Glu
         195                 200                 205            
 Val Ser Leu Ile Lys Gly Val Tyr Phe Ile Thr Ser Cys Leu Ile Lys
     210                 215                 220                
 Ile Ser
 225    



      <210> 1810
      <211> 1165
      <212> PRT
      <213> Homo sapiens


      <400> 1810
 Met Ser Leu Leu Ala Leu Trp Val Pro Pro Arg Ser Ser Ala Gly Gly
   1               5                  10                  15    
 Asp Pro Gly Gly Thr Ser Ala Leu Gly Cys Pro Arg Glu Gln Cys Cys
              20                  25                  30        
 Arg Ser Pro Glu Leu Glu Val Val Pro Ala Ala Ala Arg Ser Glu Leu
          35                  40                  45            
 Gln Gln Gly Trp Ala Ala Ala Lys Glu Pro Gly Gly Cys Thr Arg Thr
      50                  55                  60                
 Ser His Pro Gly Thr His Gly Tyr Phe Val Pro Ala Arg Val Ser Phe
  65                  70                  75                  80
 Gly Pro Thr Glu Leu Ser Leu Ile Glu Cys Arg Gln Pro Arg Ser Pro
                  85                  90                  95    
 Pro Arg Ala Glu Ala Gly Leu Gly Ser Arg Gly Leu Gly Gln Leu Phe
             100                 105                 110        
 Gln Ala Asp Ala Gly His Arg Ala Pro Met Arg Thr Val Leu Pro Arg
         115                 120                 125            
 Gly Arg Lys Arg Gly Ser Gln Pro Lys Pro Gly Gly Arg Ser Glu Lys
     130                 135                 140                
 Arg Leu Glu Gly Gly Asp Gly Pro Ala Gly Ala Gly Met Asn Lys Gly
 145                 150                 155                 160
 Trp Lys Ser Arg Arg Val Pro Ser Leu Asp Pro Pro Ala Ala Gly Ser
                 165                 170                 175    
 Glu Arg Trp Met Gly Leu Gly Trp Gly Phe Pro Val Ala Trp Gly Ser
             180                 185                 190        
 Leu Met Thr Leu Arg Leu Leu Phe Thr His Leu Leu Thr Pro Gly Leu
         195                 200                 205            
 Met Tyr His Thr Lys Val Ser Ala Val Gln Lys Pro Gly Ile Gly Phe
     210                 215                 220                
 Leu Leu Cys Arg Asp Pro Cys Gly Trp Arg Arg Glu Ala Leu Pro Arg
 225                 230                 235                 240
 Glu Glu Glu Ser Arg Glu Ala Val Trp Leu Gln Trp Leu Tyr Gln Ala
                 245                 250                 255    
 Leu Val Ser Ser Val Gln Phe Lys Leu Pro Arg Gly Phe Val Tyr Thr
             260                 265                 270        
 Val Arg Gly Lys Thr Thr Tyr Ser Ser Leu Ser Asn Asp Gly His Pro
         275                 280                 285            
 Ser Pro Thr Lys Leu Glu Cys Pro Arg Ser Ile Ser Asp Cys Cys Ala
     290                 295                 300                
 Gly Ser Lys Ile Phe Lys Pro Val Asp Leu Ser Leu Leu Gly Ser Ile
 305                 310                 315                 320
 Gly Ser Pro Pro Asp Pro Met His Arg Ala Ala Ala Ala Thr Ser Ser
                 325                 330                 335    
 Thr Asp Ile Phe Gln Gly Leu Ala Glu Pro Gly His Leu Leu Ser Lys
             340                 345                 350        
 Lys Gly Arg Gly Arg Gln Ala Cys Thr Ala Leu Thr Pro Arg His Gly
         355                 360                 365            
 Val Ile Ile Ala Val Ala Leu Glu Pro Leu Met Gly Leu Glu Ser Val
     370                 375                 380                
 Glu Arg Met Glu Arg Lys Val Thr Ser Asn Thr Cys Gln Ser Val Gln
 385                 390                 395                 400
 Leu Glu Lys Lys Ile Gln Thr Ile His Tyr Val Val Val Leu Lys Arg
                 405                 410                 415    
 Glu Cys Ala Ser Glu Ser Pro Gly Glu Val Tyr Ser Asn Thr Asp Phe
             420                 425                 430        
 Trp Asp Pro Pro Leu Glu Ile Leu Thr Gln Cys Ala Arg Gly Gly Ser
         435                 440                 445            
 Gln Glu Phe Ala Phe Leu Trp Lys Gly Asn Pro Gly Ser Ala Arg Phe
     450                 455                 460                
 Met Ala Ala Gly Leu Arg Ala Thr Lys Pro Ile Gln Ala Ala Gly Pro
 465                 470                 475                 480
 Ala Gly Trp Ala Asp Ser Leu Gly Asp Cys Val Glu Pro Asp Arg Asn
                 485                 490                 495    
 Thr Arg Val Asn Asn Val Gly Lys Ser Pro Glu Asp Thr Asp Leu Gly
             500                 505                 510        
 Ala Ala Lys Ser Arg His Pro Gly Cys Leu Ala Pro Glu Leu Gly Leu
         515                 520                 525            
 Val Phe Ala Lys Arg Thr Gln Asn Ile Phe Arg Thr Phe His Leu Leu
     530                 535                 540                
 Leu Val Phe Arg Gln Ser Gln Leu Phe Arg Glu Ile Val Asn Ile Leu
 545                 550                 555                 560
 Arg Cys Val Thr Ala Ser Leu His Tyr Lys Glu Ile Lys Gln Pro Gly
                 565                 570                 575    
 Glu Arg Gly Ala Asp Phe Asp Leu Val Cys Val Asn Ala Trp Met Leu
             580                 585                 590        
 Asp Leu Thr Gln Ala Ile Leu Asn Leu Gly Phe Leu Thr Gly Ala Phe
         595                 600                 605            
 Thr Leu Gly Tyr Ala Ala Asp Ser Arg Ser Asn Arg Asn Ile Asp Trp
     610                 615                 620                
 Lys Leu Leu Thr His Gly Cys Ile Trp Pro Asn Ile Val Leu Val Asn
 625                 630                 635                 640
 Pro Ser Leu Thr His Gly His Ile Trp Pro Asn Ile Val Leu Val Asn
                 645                 650                 655    
 Arg Ala Gln Pro Met Leu Ser Phe Ala Leu Ala Glu His Lys Ile Ile
             660                 665                 670        
 Arg Gly Lys Asn Cys Asp Lys Thr Gly Met Arg Asn Arg Leu Ile His
         675                 680                 685            
 Asp Phe Thr Gly Asp Phe Asn Ile Pro Leu Leu Glu Met Val Arg Phe
     690                 695                 700                
 Asn Arg Tyr Gly Arg Ile Val Ile Tyr Leu Leu Ser Cys Leu Gly Val
 705                 710                 715                 720
 Gly Val Thr Gly Val Val Val Ala Phe Ala Pro Asn Phe Pro Val Phe
                 725                 730                 735    
 Val Ile Phe Arg Phe Leu Gln Gly Val Phe Gly Lys Gly Thr Trp Met
             740                 745                 750        
 Thr Cys Tyr Val Ile Val Thr Glu Ile Val Gly Ser Lys Gln Arg Arg
         755                 760                 765            
 Ile Val Gly Ile Val Ile Gln Met Phe Phe Thr Leu Gly Ile Ile Ile
     770                 775                 780                
 Leu Pro Gly Ile Ala Tyr Phe Ile Pro Asn Trp Gln Gly Ile Gln Leu
 785                 790                 795                 800
 Ala Ile Thr Leu Pro Ser Phe Leu Phe Leu Leu Tyr Tyr Trp Val Val
                 805                 810                 815    
 Pro Glu Ser Pro Arg Trp Leu Ile Thr Arg Lys Lys Gly Asp Lys Ala
             820                 825                 830        
 Leu Gln Ile Leu Arg Arg Ile Ala Lys Cys Asn Gly Lys Tyr Leu Ser
         835                 840                 845            
 Ser Asn Tyr Ser Glu Asn Ser Arg Ser Gln Ile Ser Ala Val Pro Ser
     850                 855                 860                
 Gly Trp Val Ser Glu Gly Glu Leu Gln Pro Gly Ala Glu Leu Gln Gln
 865                 870                 875                 880
 Leu Thr Tyr Ser Cys Cys Met Gly His Gly Gln Glu Lys Ala Val Ser
                 885                 890                 895    
 Pro Val Asn Tyr Cys Ser Met Cys Leu His Val Leu Gln Arg Phe Gly
             900                 905                 910        
 Gly Gln Trp Ala Val Ile Gln His Arg Lys Ile Leu Arg Gly Gly Cys
         915                 920                 925            
 Ser Pro Thr Pro Leu Ile Glu Met Glu Ile Gln Phe Lys Gly Ala Leu
     930                 935                 940                
 Lys Asn Glu Ile Ala Ala Leu Glu Gln Ala Arg Gln Thr Cys Gly Met
 945                 950                 955                 960
 Pro His Gln Thr Ala Ala Phe Cys Thr Arg Asn Tyr Glu Pro His Val
                 965                 970                 975    
 Tyr Leu Val Leu His Leu Val Leu Ser Pro Cys Pro Phe Tyr Cys Gly
             980                 985                 990        
 Ser Gly Pro Ala Ser Phe Leu Pro Asp Ser Ser Ser Glu Gly Arg Phe
         995                1000                1005            
 Leu Ser Cys Pro Tyr Thr Ser Met Ala Leu Lys Gln Asp Ala Asp Ala
    1010                1015                1020                
 Val Leu Met Ala Gly Pro Ala Leu Pro Arg Asp Gly Cys Cys Gln Pro
1025                1030                1035                1040
 Ile Ser Gln Thr Thr Ser Ala Gly Glu Gly Pro Ser Asp Thr Leu Ser
                1045                1050                1055    
 Gly Ile Leu Pro Leu Tyr Gln Cys Glu Gly Arg Gly Ser Ala Ser Ser
            1060                1065                1070        
 Cys Met Leu Leu Leu Cys His Leu Val His Ser Cys Val Phe Ser Lys
        1075                1080                1085            
 Thr Ser Phe His Asn Pro Asn Tyr Cys Ala Ser Arg Leu Trp Ile Asn
    1090                1095                1100                
 Glu Lys Ile Leu Leu Ser Val Asn Ala Leu Leu Arg Gly Asp Ser Asn
1105                1110                1115                1120
 Glu Tyr Asn Phe Gln Ser Ser Ala Gln Pro Ala Thr Leu Ala Gly Val
                1125                1130                1135    
 Pro Val Leu Phe Ile Thr Gln Ser Cys Val Ala Met Ala Val Leu Leu
            1140                1145                1150        
 Ala Arg Pro Trp Thr His Gln Glu Asn Tyr Leu Ser Ser
        1155                1160                1165



      <210> 1811
      <211> 155
      <212> PRT
      <213> Homo sapiens


      <400> 1811
 Met Cys Glu Val Leu Leu Trp Pro Cys Gly Arg Ala Trp Gln Leu Arg
   1               5                  10                  15    
 Glu Pro Ala Asn Pro Leu Arg Pro His Gln Pro Pro Leu Val Ala Gln
              20                  25                  30        
 Ala Glu Gly Ala Glu Leu Arg Arg Arg Trp Leu Arg Arg Gln Arg Gly
          35                  40                  45            
 Gly Gly Gly Gly Gly Gly Gly Cys Gly Gly Arg Ser Pro Gly Pro Gly
      50                  55                  60                
 Phe Gly Leu Ser Pro Thr Met Val Thr Leu Ala Glu Leu Leu Val Leu
  65                  70                  75                  80
 Leu Ala Ala Leu Leu Ala Thr Val Ser Gly Tyr Phe Val Ser Ile Asp
                  85                  90                  95    
 Ala His Ala Glu Glu Cys Phe Phe Glu Arg Val Thr Ser Gly Thr Lys
             100                 105                 110        
 Met Gly Leu Ile Phe Glu Val Ala Glu Gly Gly Phe Arg Pro Ser Asp
         115                 120                 125            
 Arg Asn Ile Gln Asp Val Pro Ala Ile Ser Gly Cys Leu Phe Cys Arg
     130                 135                 140                
 Ala Ala Asn Pro Gly Pro Arg His Val Ser Leu
 145                 150                 155



      <210> 1812
      <211> 571
      <212> PRT
      <213> Homo sapiens


      <400> 1812
 Met Glu Thr Pro Pro Trp Asp Pro Ala Arg Asn Asp Ser Leu Pro Pro
   1               5                  10                  15    
 Thr Leu Thr Pro Ala Val Pro Pro Tyr Val Lys Leu Gly Leu Thr Val
              20                  25                  30        
 Val Tyr Thr Val Phe Tyr Ala Leu Leu Phe Val Phe Ile Tyr Val Gln
          35                  40                  45            
 Leu Trp Leu Val Leu Arg Tyr Arg His Lys Arg Leu Ser Tyr Gln Ser
      50                  55                  60                
 Val Phe Leu Phe Leu Cys Leu Phe Trp Ala Ser Leu Arg Thr Val Leu
  65                  70                  75                  80
 Phe Ser Phe Tyr Phe Lys Asp Phe Val Ala Ala Asn Ser Leu Ser Pro
                  85                  90                  95    
 Phe Val Phe Trp Leu Leu Tyr Cys Phe Pro Val Cys Leu Gln Phe Phe
             100                 105                 110        
 Thr Leu Thr Leu Met Asn Leu Tyr Phe Thr Gln Glu Thr Pro Cys His
         115                 120                 125            
 Ser Gln Lys Gly Gln Gly Glu Gly Arg Gly Gly Leu Glu Ala Ala Ala
     130                 135                 140                
 His Ser Leu Pro Leu Ala Pro His Arg Ala Val Asp Ser Gly Arg Phe
 145                 150                 155                 160
 Ser Val Arg Ser Ala Lys Gln Gln Arg Leu His Thr Pro Val Ser Thr
                 165                 170                 175    
 Asp Gly Arg Pro Gln Asn Gly Ile Ser Thr Asp Ser Leu His Cys Ala
             180                 185                 190        
 Pro Gly Lys Ala Thr Asp Thr Gln His Gln Pro Val Lys Ala Ala Gly
         195                 200                 205            
 Arg Glu Ala Val Pro Cys Lys Ala Thr Gly Val Glu Leu Pro Lys Thr
     210                 215                 220                
 Met Gly Thr His Leu Leu His His Cys Asp Leu Asp Val Ile Phe Lys
 225                 230                 235                 240
 Ala Lys Ser Lys Tyr Ser Pro Glu Leu Leu Lys Tyr Arg Leu Pro Leu
                 245                 250                 255    
 Tyr Leu Ala Ser Leu Phe Ile Ser Leu Val Phe Leu Leu Val Asn Leu
             260                 265                 270        
 Thr Cys Ala Val Leu Val Lys Thr Gly Asn Trp Glu Arg Lys Val Ile
         275                 280                 285            
 Val Ser Val Arg Val Ala Ile Asn Asp Thr Leu Phe Val Leu Cys Ala
     290                 295                 300                
 Val Ser Leu Ser Ile Cys Leu Tyr Lys Ile Ser Lys Met Ser Leu Ala
 305                 310                 315                 320
 Asn Ile Tyr Leu Glu Ser Lys Gly Ser Ser Val Cys Gln Val Thr Ala
                 325                 330                 335    
 Ile Gly Val Thr Val Ile Leu Leu Tyr Thr Ser Arg Ala Cys Tyr Asn
             340                 345                 350        
 Leu Phe Ile Leu Ser Phe Ser Gln Asn Lys Ser Val His Ser Phe Asp
         355                 360                 365            
 Tyr Asp Trp Tyr Asn Val Ser Asp Gln Val Glu Cys Phe Gln Leu Phe
     370                 375                 380                
 Leu Ile Gln Tyr Asn Val Gly Cys Gly Phe Val Ile Asp Gly Phe Tyr
 385                 390                 395                 400
 Tyr Leu Asp Thr Asn Pro Gly Met Val Pro Ser His Gly Phe Ser Pro
                 405                 410                 415    
 Arg Ser Tyr Phe Phe Asp Asn Pro Arg Arg Tyr Asp Ser Asp Asp Asp
             420                 425                 430        
 Leu Ala Trp Asn Ile Ala Pro Gln Gly Leu Gln Gly Gly Leu Leu Cys
         435                 440                 445            
 Ser Ala Ile Leu His Tyr Pro Met Thr Ile Met Phe Pro Leu Ser Ala
     450                 455                 460                
 Cys Gly Ser Glu Thr Ile Cys Ile Ser Asn Cys Leu Pro Glu Ile Ser
 465                 470                 475                 480
 Lys Trp Met Ser His Arg Gln Leu Lys Leu Asn Lys Ser Lys Phe Asp
                 485                 490                 495    
 Tyr Asn Phe Val Ser Asp Leu Leu Leu Leu Gln Leu Ser Thr Ala Ser
             500                 505                 510        
 Leu Gln Gly Lys Lys Lys Pro Lys His Thr Ser Asn Ile Pro Ile Ser
         515                 520                 525            
 Leu Val Ile Ser Gln Gly Asn Gly Phe Tyr Thr Thr Ser Leu Lys Ala
     530                 535                 540                
 Ile Val Gln Leu Asp Ser Asn Phe Leu Glu Ala Thr Lys Asn Arg Asp
 545                 550                 555                 560
 Ser Arg Leu Asp Lys His Lys Val Leu Arg Asn
                 565                 570    



      <210> 1813
      <211> 901
      <212> PRT
      <213> Homo sapiens


      <400> 1813
 Met Met Met Val Met Val Met Met Met Leu Met Met Met Val Ile Met
   1               5                  10                  15    
 Met Val Met Val Val Met Leu Met Met Leu Leu Leu Met Met Met Leu
              20                  25                  30        
 Met Met Val Met Met Met Val Met Met Val Ile Val Met Met Met Val
          35                  40                  45            
 Ile Met Val Val Met Met Val Met Met Thr Val Met Ile Met Val Met
      50                  55                  60                
 Val Val Met Leu Met Leu Val Met Val Val Met Met Met Val Met Val
  65                  70                  75                  80
 Val Met Leu Met Leu Val Met Val Val Met Met Met Met Met Glu Leu
                  85                  90                  95    
 Val Leu Pro Phe Leu Ala Leu Ser Arg Ala Ala Gly Ile Ser Tyr Asp
             100                 105                 110        
 Cys Pro Ile Ala Ala Ala Ser Ala Ala Pro Ala Arg Gly Ile Thr Glu
         115                 120                 125            
 Asp Ser Lys Leu Thr Val Val Val Leu Ser Pro Arg Met Glu Glu Ala
     130                 135                 140                
 Ser Leu Cys Leu Gly Val Ser Ser Ala Glu Pro Glu Ala Glu Pro His
 145                 150                 155                 160
 Leu Ser Gly Pro Val Leu Asn Gly Gln Tyr Ala Met Ser Gln Lys Leu
                 165                 170                 175    
 His Gln Ile Thr Ser Gln Leu Ser His Ala Phe Pro Glu Leu His Pro
             180                 185                 190        
 Arg Pro Asn Pro Glu Glu Lys Pro Pro Ala Ser Leu Glu Glu Lys Ala
         195                 200                 205            
 His Val Pro Met Ser Gly Gln Pro Met Gly Ser Gln Met Ala Leu Leu
     210                 215                 220                
 Ala Asn Gln Leu Gly Arg Glu Val Asp Thr Ser Leu Asn Gly Arg Val
 225                 230                 235                 240
 Asp Leu Gln Gln Phe Leu Asn Gly Gln Asn Leu Gly Ile Met Ser Gln
                 245                 250                 255    
 Met Ser Asp Ile Glu Asp Asp Ala Arg Lys Asn Arg Lys Tyr Pro Cys
             260                 265                 270        
 Pro Leu Cys Gly Lys Arg Phe Arg Phe Asn Ser Ile Leu Ser Leu His
         275                 280                 285            
 Met Arg Thr His Thr Gly Glu Lys Pro Phe Lys Cys Pro Tyr Cys Asp
     290                 295                 300                
 His Arg Ala Ala Gln Lys Gly Asn Leu Lys Ile His Leu Arg Thr His
 305                 310                 315                 320
 Lys Leu Gly Asn Leu Gly Lys Gly Arg Gly Arg Val Arg Glu Glu Asn
                 325                 330                 335    
 Arg Leu Leu His Glu Leu Glu Glu Arg Ala Ile Leu Arg Asp Lys Gln
             340                 345                 350        
 Leu Lys Gly Ser Leu Leu Gln Pro Arg Pro Asp Leu Lys Pro Pro Pro
         355                 360                 365            
 His Ala Gln Gln Ala Pro Leu Ala Ala Cys Thr Leu Ala Leu Gln Ala
     370                 375                 380                
 Asn His Ser Val Pro Asp Val Ala His Pro Val Pro Ser Pro Lys Pro
 385                 390                 395                 400
 Ala Ser Val Gln Glu Asp Ala Val Ala Pro Ala Ala Gly Phe Arg Cys
                 405                 410                 415    
 Thr Phe Cys Lys Gly Lys Phe Lys Lys Arg Glu Glu Leu Asp Arg His
             420                 425                 430        
 Ile Arg Ile Leu His Lys Pro Tyr Lys Cys Thr Leu Cys Asp Phe Ala
         435                 440                 445            
 Ala Ser Gln Glu Glu Glu Leu Ile Ser His Val Glu Lys Ala His Ile
     450                 455                 460                
 Thr Ala Glu Ser Ala Gln Gly Gln Gly Pro Asn Gly Gly Gly Glu Gln
 465                 470                 475                 480
 Ser Ala Asn Glu Phe Arg Cys Glu Val Cys Gly Gln Val Phe Ser Gln
                 485                 490                 495    
 Ala Trp Phe Leu Lys Gly His Met Arg Lys His Lys Asp Ser Phe Glu
             500                 505                 510        
 His Cys Cys Gln Ile Cys Gly Arg Arg Phe Lys Glu Pro Trp Phe Leu
         515                 520                 525            
 Lys Asn His Met Lys Val His Leu Asn Lys Leu Ser Val Lys Asn Lys
     530                 535                 540                
 Ser Pro Ser Asp Pro Glu Val Pro Val Pro Met Gly Gly Met Ser Gln
 545                 550                 555                 560
 Glu Ala His Ala Asn Leu Tyr Ser Arg Tyr Leu Ser Cys Leu Gln Ser
                 565                 570                 575    
 Gly Phe Met Thr Pro Asp Lys Ala Gly Leu Ser Glu Pro Ser Gln Leu
             580                 585                 590        
 Tyr Gly Lys Gly Glu Leu Pro Met Lys Glu Lys Glu Ala Leu Gly Lys
         595                 600                 605            
 Leu Leu Ser Pro Ile Ser Ser Met Ala His Gly Val Pro Glu Gly Asp
     610                 615                 620                
 Lys His Ser Leu Leu Gly Cys Leu Asn Leu Val Pro Pro Leu Lys Ser
 625                 630                 635                 640
 Ser Cys Ile Glu Arg Leu Gln Ala Ala Ala Lys Ala Ala Glu Met Asp
                 645                 650                 655    
 Pro Val Asn Ser Tyr Gln Ala Trp Gln Leu Met Ala Arg Gly Met Ala
             660                 665                 670        
 Met Glu His Gly Phe Leu Ser Lys Glu His Pro Leu Gln Arg Asn His
         675                 680                 685            
 Glu Asp Thr Leu Ala Asn Ala Gly Val Leu Phe Asp Lys Glu Lys Arg
     690                 695                 700                
 Glu Tyr Val Leu Val Gly Ala Asp Gly Ser Lys Gln Lys Met Pro Ala
 705                 710                 715                 720
 Asp Leu Val His Ser Thr Lys Val Gly Ser Gln Arg Asp Leu Pro Ser
                 725                 730                 735    
 Lys Leu Asp Pro Leu Glu Ser Ser Arg Asp Phe Leu Ser His Gly Leu
             740                 745                 750        
 Asn Gln Thr Leu Glu Tyr Asn Leu Gln Gly Pro Gly Asn Met Lys Glu
         755                 760                 765            
 Lys Pro Thr Glu Cys Pro Asp Cys Gly Arg Val Phe Arg Thr Tyr His
     770                 775                 780                
 Gln Val Val Val His Ser Arg Val His Lys Arg Asp Arg Lys Gly Glu
 785                 790                 795                 800
 Glu Asp Gly Leu His Val Gly Leu Asp Glu Arg Arg Gly Ser Gly Ser
                 805                 810                 815    
 Asp Gln Glu Ser Gln Ser Val Ser Arg Ser Thr Thr Pro Gly Ser Ser
             820                 825                 830        
 Asn Val Thr Glu Glu Ser Gly Val Gly Gly Gly Leu Ser Gln Thr Gly
         835                 840                 845            
 Ser Ala Gln Glu Asp Ser Pro His Pro Ser Ser Pro Ser Ser Ser Ala
     850                 855                 860                
 Tyr Ser His Asn Ser Leu Met Gln Ala Pro Gln Ser Pro Ser Pro Ser
 865                 870                 875                 880
 Gln Thr Tyr Leu Leu Ala Pro Ser Lys Ile Thr Thr Trp Leu Thr Cys
                 885                 890                 895    
 Gln Ile Arg Val Thr
             900    



      <210> 1814
      <211> 578
      <212> PRT
      <213> Homo sapiens


      <400> 1814
 Met Pro Ser Tyr Ala Gln Leu Val Gln Arg Gly Trp Gly Ser Ala Leu
   1               5                  10                  15    
 Ala Ala Ala Arg Gly Cys Thr Asp Cys Gly Trp Gly Leu Ala Arg Arg
              20                  25                  30        
 Gly Leu Ala Glu His Ala His Leu Ala Pro Pro Glu Leu Leu Leu Leu
          35                  40                  45            
 Ala Leu Gly Ala Leu Gly Trp Thr Ala Leu Arg Ser Ala Ala Thr Ala
      50                  55                  60                
 Arg Leu Phe Arg Val Ser Val Ala Gly Gly Arg Asp Glu Gly Thr Pro
  65                  70                  75                  80
 Asp Trp Gly Lys Pro Gly Pro Gly Thr Trp Gly Arg Arg Arg Val Pro
                  85                  90                  95    
 Phe Phe Gln Arg Trp Leu Leu Arg Met Lys Gly Ser Pro Glu Arg Gly
             100                 105                 110        
 Ala Glu Pro Asp Thr Glu Lys Pro Arg Thr Gly Asn Gly Arg Ala Arg
         115                 120                 125            
 Arg Thr Ala Ala Cys Ala Met Arg Leu Pro Ala Met Arg Ala Ala Pro
     130                 135                 140                
 Arg Pro Gly Ala Arg Ser Ala Ala Arg Phe Leu Leu Gly Pro Cys Gly
 145                 150                 155                 160
 Gly Gly Ala Gly Leu Pro Ala Val Ile Gly Lys Arg Gln Glu Leu Pro
                 165                 170                 175    
 Gly Arg Cys Leu Val Pro Ile Trp Gly Gln Arg His Pro Pro Thr Arg
             180                 185                 190        
 Asp Gly Lys Gly Leu Gly Ala Leu Ala Thr Pro Val Val Ala Pro Leu
         195                 200                 205            
 Glu Pro Leu Ala Lys Arg Cys Cys Leu Gln Pro Arg Asp Ala Ala Lys
     210                 215                 220                
 Met Pro Glu Ser Ala Trp Lys Phe Leu Phe Tyr Leu Gly Ser Trp Ser
 225                 230                 235                 240
 Tyr Ser Ala Tyr Leu Leu Phe Gly Thr Asp Tyr Pro Phe Phe His Asp
                 245                 250                 255    
 Pro Pro Ser Val Phe Tyr Asp Trp Thr Pro Gly Met Ala Val Pro Arg
             260                 265                 270        
 Asp Ile Ala Ala Ala Tyr Leu Leu Gln Gly Ser Phe Tyr Gly His Ser
         275                 280                 285            
 Ile Tyr Ala Thr Leu Tyr Met Asp Thr Trp Arg Lys Asp Ser Val Val
     290                 295                 300                
 Met Leu Leu His His Val Val Thr Leu Ile Leu Ile Val Ser Ser Tyr
 305                 310                 315                 320
 Ala Phe Arg Tyr His Asn Val Gly Ile Leu Val Leu Phe Leu His Asp
                 325                 330                 335    
 Ile Ser Asp Val Gln Leu Glu Phe Thr Lys Leu Asn Ile Tyr Phe Lys
             340                 345                 350        
 Ser Arg Gly Gly Ser Tyr His Arg Leu His Ala Leu Ala Ala Asp Leu
         355                 360                 365            
 Gly Cys Leu Ser Phe Gly Phe Ser Trp Phe Trp Phe Arg Leu Tyr Trp
     370                 375                 380                
 Phe Pro Leu Lys Val Leu Tyr Ala Thr Ser His Cys Ser Leu Arg Thr
 385                 390                 395                 400
 Val Pro Asp Ile Pro Phe Tyr Phe Phe Phe Asn Ala Leu Leu Leu Leu
                 405                 410                 415    
 Leu Thr Leu Met Asn Leu Tyr Trp Phe Leu Tyr Ile Val Ala Phe Ala
             420                 425                 430        
 Ala Lys Val Leu Thr Gly Gln Val His Glu Leu Lys Asp Leu Arg Glu
         435                 440                 445            
 Tyr Asp Thr Ala Glu Ala Gln Ser Leu Lys Pro Ser Lys Ala Glu His
     450                 455                 460                
 His Gln Gln Asn Ser Ile Leu Gln Gly Gln Pro Glu Leu Val Gln Leu
 465                 470                 475                 480
 Gly Ile Lys Gln Asp Gly Thr Lys Ala Val Arg Leu Arg Asp Val Phe
                 485                 490                 495    
 Gln Lys Ser Pro Ser Gly Cys Pro Glu Thr Val Lys Ile Met Gly Ile
             500                 505                 510        
 Arg Glu Arg Pro Arg Asn Asn Pro Gly Ser Glu Glu Thr Lys Glu Thr
         515                 520                 525            
 Asp Ala Thr Cys Ser Met Gly Ser Trp Thr Arg Lys Gly Thr Phe Thr
     530                 535                 540                
 Lys Lys Leu Val Asn Ser Asn His Val Glu Ser Leu Val Asn Ser Lys
 545                 550                 555                 560
 Ala Pro Met Ser Val Ser Leu Ala Ala Thr His Val Pro Trp Lys Cys
                 565                 570                 575    
 Lys Leu
        



      <210> 1815
      <211> 520
      <212> PRT
      <213> Homo sapiens


      <400> 1815
 Met Gly Pro Ala Gly Cys Ala Phe Thr Leu Leu Leu Leu Leu Gly Ile
   1               5                  10                  15    
 Ser Val Cys Gly Gln Pro Val Tyr Ser Ser Arg Val Val Gly Gly Gln
              20                  25                  30        
 Asp Ala Ala Ala Gly Arg Trp Pro Trp Gln Val Ser Leu His Phe Asp
          35                  40                  45            
 His Asn Phe Ile Cys Gly Gly Ser Leu Val Ser Glu Arg Leu Ile Leu
      50                  55                  60                
 Thr Ala Ala His Cys Ile Gln Pro Ser His Arg Arg Ile Cys Ser Thr
  65                  70                  75                  80
 Lys Ile Lys Gly Glu Lys Gln Glu Asn Thr Gly Ser Arg Gln Lys Gly
                  85                  90                  95    
 Asn Lys Thr Gln Lys Arg Ile Pro Lys Lys Val Ile Lys Asp Lys Glu
             100                 105                 110        
 Ser Ala Lys Met Met Ala Val Gln Gln Pro Arg Leu Glu Gln Glu Ser
         115                 120                 125            
 Arg Gly Leu Gln Lys Lys Asp Ser Ile Asp Arg Met Pro Asp Lys Phe
     130                 135                 140                
 Glu Gln Asn Glu Arg Arg Phe Thr Leu Leu Val Glu Ser Leu Gly Asn
 145                 150                 155                 160
 Glu Thr Gly Asp Gly Tyr Lys Asp Lys Asn Lys Lys Pro Lys Thr Trp
                 165                 170                 175    
 Thr Thr Phe Ser Tyr Thr Val Trp Leu Gly Ser Ile Thr Val Gly Asp
             180                 185                 190        
 Ser Arg Lys Arg Val Lys Tyr Tyr Val Ser Lys Ile Val Ile His Pro
         195                 200                 205            
 Lys Tyr Gln Asp Thr Thr Ala Asp Val Ala Leu Leu Lys Leu Ser Ser
     210                 215                 220                
 Gln Val Thr Phe Thr Ser Ala Ile Leu Pro Ile Cys Leu Pro Ser Val
 225                 230                 235                 240
 Thr Lys Gln Leu Ala Ile Pro Pro Phe Cys Trp Val Thr Gly Trp Gly
                 245                 250                 255    
 Lys Val Lys Glu Ser Ser Asp Arg Asp Tyr His Ser Ala Leu Gln Glu
             260                 265                 270        
 Ala Glu Val Pro Ile Ile Asp Arg Gln Ala Cys Glu Gln Leu Tyr Asn
         275                 280                 285            
 Pro Ile Gly Ile Phe Leu Pro Ala Leu Glu Pro Val Ile Lys Glu Asp
     290                 295                 300                
 Lys Ile Cys Ala Gly Asp Thr Gln Asn Met Lys Asp Ser Cys Lys Gly
 305                 310                 315                 320
 Asp Ser Gly Gly Pro Leu Ser Cys His Ile Asp Gly Val Trp Ile Gln
                 325                 330                 335    
 Thr Gly Val His Phe Lys Gly Ile Leu Leu Leu Leu Thr Glu Ile Cys
             340                 345                 350        
 Glu Tyr Val Thr Thr Arg Ser Lys Gly Asp Phe Ala His Met Ile Lys
         355                 360                 365            
 Tyr Pro Glu Met Gly Thr Ser Ser Val Leu Ser Gly Gly Thr Asn Val
     370                 375                 380                
 Ile Asn His Met Ala Ser Tyr Lys Ser Lys Ile Gly Gly Ser Gly Pro
 385                 390                 395                 400
 Val Ser Pro Phe Leu Pro Glu Gln His Glu Pro Ser Leu Ala Lys Tyr
                 405                 410                 415    
 Pro Asn Leu His Leu Ser Phe Lys Ser Gln Ile Asn Gln Asp Pro Arg
             420                 425                 430        
 Trp Arg Ser Pro Arg Glu Pro Lys Lys Pro Leu Ala Ser Gly Arg Gln
         435                 440                 445            
 Pro Leu Gly Ser Ala Phe Pro Glu Phe Leu Val Leu Asp Pro Ser Gly
     450                 455                 460                
 Arg Thr Ser Leu Gln Phe Leu Lys Val Arg Pro Thr Ala Ala Glu Glu
 465                 470                 475                 480
 Gln Gly Leu Val Pro Ala Ala Ser Lys Gln Gly Gly Gln Ala Ser Ala
                 485                 490                 495    
 Arg Ala Phe Ser Phe Leu Pro Cys Val Lys Leu Ser Lys Leu Pro Pro
             500                 505                 510        
 Gln Pro Leu Pro Cys Pro Met Pro
         515                 520



      <210> 1816
      <211> 213
      <212> PRT
      <213> Homo sapiens


      <400> 1816
 Met Thr Leu Ala Leu Ser Ser Thr Ala Ile Ala Met Gln Ala Met Asn
   1               5                  10                  15    
 Glu Arg Asn Leu Met Val Thr Gln Met Gly Arg Ser Ala Phe Ala Val
              20                  25                  30        
 Leu Leu Phe Gln Asp Ile Ala Ala Ile Pro Leu Val Ala Met Ile Pro
          35                  40                  45            
 Leu Leu Ala Thr Ser Ser Ala Ser Thr Thr Met Gly Ala Phe Ala Leu
      50                  55                  60                
 Ser Ala Leu Lys Val Ala Gly Ala Leu Val Leu Val Val Leu Leu Gly
  65                  70                  75                  80
 Arg Tyr Val Thr Arg Pro Ala Leu Arg Phe Val Ala Arg Ser Gly Leu
                  85                  90                  95    
 Arg Glu Val Phe Ser Ala Val Ala Leu Phe Leu Val Phe Gly Phe Gly
             100                 105                 110        
 Leu Leu Leu Glu Glu Val Gly Leu Ser Met Ala Met Gly Ala Phe Leu
         115                 120                 125            
 Ala Gly Val Leu Leu Ala Ser Ser Glu Tyr Arg His Ala Leu Glu Ser
     130                 135                 140                
 Asp Ile Glu Pro Phe Lys Asp His Ser Ala Ile Lys Leu Glu Leu Arg
 145                 150                 155                 160
 Ile Lys Asn Leu Thr Gln Ser Arg Ser Thr Thr Trp Lys Leu Asn Asn
                 165                 170                 175    
 Leu Leu Leu Asn Asp Tyr Trp Val His Asn Glu Met Lys Ala Glu Ile
             180                 185                 190        
 Lys Met Phe Phe Glu Thr Gly Tyr Arg Ala Lys Ser Arg Ile Arg Glu
         195                 200                 205            
 Ala Gly Arg Pro Pro
     210            



      <210> 1817
      <211> 400
      <212> PRT
      <213> Homo sapiens


      <400> 1817
 Met Ser Ala Leu Ala Gly Val Lys Ser Val Gln Gln Val Leu Trp Phe
   1               5                  10                  15    
 Val Ile Leu Pro Gly Ala Leu Pro Glu Ile Leu Thr Gly Leu Arg Ile
              20                  25                  30        
 Gly Leu Gly Val Gly Trp Ser Thr Leu Val Ala Ala Glu Leu Ile Ala
          35                  40                  45            
 Ala Thr Arg Gly Leu Gly Phe Met Val Gln Ser Ala Gly Glu Phe Leu
      50                  55                  60                
 Ala Thr Asp Val Val Leu Ala Gly Ile Ala Val Ile Ala Ile Ile Ala
  65                  70                  75                  80
 Phe Leu Leu Glu Leu Gly Leu Arg Ala Leu Gln Arg Arg Leu Thr Pro
                  85                  90                  95    
 Leu Ala Trp Arg Ser Thr Met Ser Glu Arg Leu Ser Ile Thr Pro Leu
             100                 105                 110        
 Gly Pro Tyr Ile Gly Ala Gln Ile Ser Gly Ala Asp Leu Thr Arg Pro
         115                 120                 125            
 Leu Ser Asp Asn Gln Phe Glu Gln Leu Tyr His Ala Val Leu Arg His
     130                 135                 140                
 Gln Val Val Phe Leu Arg Asp Gln Ala Ile Thr Pro Gln Gln Gln Arg
 145                 150                 155                 160
 Ala Leu Ala Gln Arg Phe Gly Glu Leu His Ile His Pro Val Tyr Pro
                 165                 170                 175    
 His Ala Glu Gly Val Asp Glu Ile Ile Val Leu Asp Thr His Asn Asp
             180                 185                 190        
 Asn Pro Pro Asp Asn Asp Asn Trp His Thr Asp Val Thr Phe Ile Glu
         195                 200                 205            
 Thr Pro Pro Ala Gly Ala Ile Leu Ala Ala Lys Glu Leu Pro Ser Thr
     210                 215                 220                
 Gly Gly Asp Thr Leu Trp Thr Ser Gly Ile Ala Ala Tyr Glu Ala Leu
 225                 230                 235                 240
 Ser Val Pro Phe Arg Gln Leu Leu Ser Gly Leu Arg Ala Glu His Asp
                 245                 250                 255    
 Phe Arg Lys Ser Phe Pro Glu Tyr Lys Tyr Arg Lys Thr Glu Glu Glu
             260                 265                 270        
 His Gln Arg Trp Arg Glu Ala Val Ala Lys Asn Pro Pro Leu Leu His
         275                 280                 285            
 Pro Val Val Arg Thr His Pro Val Ser Gly Lys Gln Ala Leu Phe Val
     290                 295                 300                
 Asn Glu Gly Phe Thr Thr Arg Ile Val Asp Val Ser Glu Lys Glu Ser
 305                 310                 315                 320
 Glu Ala Leu Leu Ser Phe Leu Phe Ala His Ile Thr Lys Pro Glu Phe
                 325                 330                 335    
 Gln Val Arg Trp Arg Trp Gln Pro Asn Asp Ile Ala Ile Trp Asp Asn
             340                 345                 350        
 Arg Val Thr Gln His Tyr Ala Asn Ala Asp Tyr Leu Pro Gln Arg Arg
         355                 360                 365            
 Ile Met His Arg Ala Thr Ile Leu Gly Asp Lys Pro Phe Tyr Arg Ala
     370                 375                 380                
 Gly Val Ile Arg Glu Trp Thr Val Pro Ser Pro Leu Trp Gly Glu Gly
 385                 390                 395                 400





      <210> 1818
      <211> 196
      <212> PRT
      <213> Homo sapiens


      <400> 1818
 Met Glu Leu Cys Ile Leu Ala Phe Gly Phe Ala Leu Ile Val Gly Ile
   1               5                  10                  15    
 Pro Val Gly Met Ile Ala Gly Ile Thr Arg His Lys Trp Gln Asp Asn
              20                  25                  30        
 Leu Ile Asn Ala Ile Ala Leu Leu Gly Phe Ser Ile Pro Val Phe Trp
          35                  40                  45            
 Leu Ala Leu Leu Leu Thr Leu Phe Cys Ser Leu Thr Leu Gly Trp Leu
      50                  55                  60                
 Pro Val Ser Gly Arg Phe Asp Leu Leu Tyr Glu Val Lys Pro Ile Thr
  65                  70                  75                  80
 Gly Phe Ala Leu Ile Asp Ala Trp Leu Ser Asp Ser Pro Trp Arg Asp
                  85                  90                  95    
 Glu Met Ile Met Ser Ala Ile Arg His Met Ile Leu Pro Val Ile Thr
             100                 105                 110        
 Leu Ser Val Ala Pro Thr Thr Glu Val Ile Arg Leu Met Arg Ile Ser
         115                 120                 125            
 Thr Ile Glu Val Tyr Asp Gln Asn Tyr Val Lys Ala Ala Ala Thr Arg
     130                 135                 140                
 Gly Leu Ser Arg Phe Thr Ile Leu Arg Arg His Val Leu His Asn Ala
 145                 150                 155                 160
 Leu Pro Pro Val Ile Pro Arg Leu Gly Leu His Pro Ser Thr Met Leu
                 165                 170                 175    
 Thr Leu Ala Met Ile Thr Glu Met Val Leu Gly Gly Ala Phe Glu Ser
             180                 185                 190        
 Thr Glu Gly Glu
         195    



      <210> 1819
      <211> 1531
      <212> PRT
      <213> Homo sapiens


      <400> 1819
 Met Asp Ala Gly Lys Ala Gly Gln Thr Leu Lys Thr His Cys Ser Ala
   1               5                  10                  15    
 Gln Arg Pro Asp Val Cys Arg Trp Leu Ser Pro Phe Ile Leu Ser Cys
              20                  25                  30        
 Cys Val Tyr Phe Cys Leu Trp Ile Pro Glu Asp Gln Leu Ser Trp Phe
          35                  40                  45            
 Ala Ala Leu Val Lys Cys Leu Pro Val Leu Cys Leu Ala Gly Phe Leu
      50                  55                  60                
 Trp Val Met Ser Pro Ser Gly Gly Tyr Thr Gln Leu Leu Gln Gly Ala
  65                  70                  75                  80
 Leu Val Cys Ser Ala Val Gly Asp Ala Cys Leu Ile Trp Pro Ala Ala
                  85                  90                  95    
 Phe Val Pro Gly Met Ala Ala Phe Ala Thr Ala His Leu Leu Tyr Val
             100                 105                 110        
 Trp Ala Phe Gly Phe Ser Pro Leu Gln Pro Gly Leu Leu Leu Leu Ile
         115                 120                 125            
 Ile Leu Ala Pro Gly Pro Tyr Leu Ser Leu Val Leu Gln His Leu Glu
     130                 135                 140                
 Pro Asp Met Val Leu Pro Val Ala Ala Tyr Gly Leu Ile Leu Met Ala
 145                 150                 155                 160
 Met Leu Trp Arg Gly Leu Ala Gln Gly Gly Ser Ala Gly Trp Gly Ala
                 165                 170                 175    
 Leu Leu Phe Thr Leu Ser Asp Gly Val Leu Ala Trp Asp Thr Phe Ala
             180                 185                 190        
 Gln Pro Leu Pro His Ala His Leu Val Ile Met Thr Thr Tyr Tyr Ala
         195                 200                 205            
 Ala Gln Leu Leu Ile Thr Leu Ser Ala Leu Arg Ser Pro Ala Leu Gly
     210                 215                 220                
 Thr Thr Thr Glu Ala Thr Ala Ala Glu Ala Ser Thr His Val Ser Arg
 225                 230                 235                 240
 Gln Ser Arg Gln Asn Arg Glu Cys Gly Gly Ser Asp Leu Gln Leu His
                 245                 250                 255    
 His Pro Glu Leu Gly Ser Pro Lys Gly Pro Asp Arg Gln Thr Ser Ile
             260                 265                 270        
 Tyr Trp Val Gln Gly His Gly Gln Arg Glu His Lys His Val Thr Leu
         275                 280                 285            
 Leu Ala Arg Gly Gly Gly Leu Gln Pro Gly Thr Leu Tyr Thr Thr Ser
     290                 295                 300                
 Val Trp Ala Lys Lys Lys Gly Val Gly Gly Pro Arg Asp Val Leu Ser
 305                 310                 315                 320
 Met Ser Thr Gly Pro Asp Ser Lys Thr Cys Pro Tyr Trp Leu Cys Trp
                 325                 330                 335    
 Ala Ser Asp Ser Ser Asp Ile Arg Val Pro Val Glu Gly Leu Ala Ala
             340                 345                 350        
 Gly Thr Gln Tyr Pro Ser Met Trp Ala Gln Lys His Glu Val Asn Ser
         355                 360                 365            
 Pro Ser Gln Thr Leu Thr Glu Ala Thr Gly Glu Gly Leu Tyr Leu Pro
     370                 375                 380                
 Ser Pro Arg Val Thr Ser Leu Leu Ile Phe Ile Ile Cys Glu His Gly
 385                 390                 395                 400
 Ser Arg Arg Thr Pro Ala Leu Leu Gln Val Asp Glu Ser Gly Pro Cys
                 405                 410                 415    
 His Phe Leu Asp Leu Ser Ile Leu Ala Ala Arg Lys Ala Arg Lys Ser
             420                 425                 430        
 Glu Asn Lys Gly Trp Ile Gln Arg Lys His Gly Asn Thr Gly His Ser
         435                 440                 445            
 His Ser Gly Leu Cys Ser Trp Thr Gly Ala Arg Ala Pro Ala Pro Asn
     450                 455                 460                
 Pro Gly Arg Asn Leu Thr Val Glu Thr Gln Thr Thr Ser Ser Ile Ser
 465                 470                 475                 480
 Leu Ser Trp Glu Val Pro Asp Gly Leu Asp Ser Gln Asn Ser Asn Tyr
                 485                 490                 495    
 Trp Val Gln Cys Thr Gly Asp Gly Gly Thr Thr Glu Thr Arg Asn Thr
             500                 505                 510        
 Thr Ala Thr Asn Val Thr Val Asp Gly Leu Gly Pro Gly Ser Leu Tyr
         515                 520                 525            
 Thr Cys Ser Val Trp Val Glu Lys Asp Gly Val Asn Ser Ser Val Gly
     530                 535                 540                
 Thr Val Thr Thr Ala Thr Ala Pro Asn Pro Val Arg Asn Leu Arg Val
 545                 550                 555                 560
 Glu Ala Gln Thr Asn Ser Ser Ile Ala Leu Thr Trp Glu Val Pro Asp
                 565                 570                 575    
 Gly Pro Asp Pro Gln Asn Ser Thr Tyr Gly Val Glu Tyr Thr Gly Asp
             580                 585                 590        
 Gly Gly Arg Ala Gly Thr Arg Ser Thr Ala His Thr Asn Ile Thr Val
         595                 600                 605            
 Asp Gly Leu Glu Pro Gly Cys Leu Tyr Ala Phe Ser Met Trp Val Gly
     610                 615                 620                
 Lys Asn Gly Ile Asn Ser Ser Arg Glu Thr Arg Asn Ala Thr Thr Ala
 625                 630                 635                 640
 His Asn Pro Val Arg Asn Leu Arg Val Glu Ala Gln Thr Thr Ser Ser
                 645                 650                 655    
 Ile Ser Leu Ser Trp Glu Val Pro Asp Gly Thr Asp Pro Gln Asn Ser
             660                 665                 670        
 Thr Tyr Cys Val Gln Cys Thr Gly Asp Gly Gly Arg Thr Glu Thr Arg
         675                 680                 685            
 Asn Thr Thr Asp Thr Arg Val Thr Val Asp Gly Leu Gly Pro Gly Ser
     690                 695                 700                
 Leu Tyr Thr Cys Ser Val Trp Val Glu Lys Asp Gly Val Asn Ser Ser
 705                 710                 715                 720
 Val Glu Ile Val Thr Ser Ala Thr Ala Pro Asn Pro Val Arg Asn Leu
                 725                 730                 735    
 Thr Val Glu Ala Gln Thr Asn Ser Ser Ile Ala Leu Thr Trp Glu Val
             740                 745                 750        
 Pro Asp Gly Pro Asp Pro Gln Asn Ser Thr Tyr Gly Val Glu Tyr Thr
         755                 760                 765            
 Gly Asp Gly Gly Arg Ala Gly Thr Arg Ser Thr Ala His Thr Asn Ile
     770                 775                 780                
 Thr Val Asp Arg Leu Glu Pro Gly Cys Leu Tyr Val Phe Ser Val Trp
 785                 790                 795                 800
 Val Gly Lys Asn Gly Ile Asn Ser Ser Arg Glu Thr Arg Asn Ala Thr
                 805                 810                 815    
 Thr Ala Pro Asn Pro Val Arg Asn Leu His Met Glu Thr Gln Thr Asn
             820                 825                 830        
 Ser Ser Ile Ala Leu Cys Trp Glu Val Pro Asp Gly Pro Tyr Pro Gln
         835                 840                 845            
 Asp Tyr Thr Tyr Trp Val Glu Tyr Thr Gly Asp Gly Gly Gly Thr Glu
     850                 855                 860                
 Thr Arg Asn Thr Thr Asn Thr Ser Val Thr Ala Glu Arg Leu Glu Pro
 865                 870                 875                 880
 Gly Thr Leu Tyr Thr Phe Ser Val Trp Ala Glu Lys Asn Gly Ala Arg
                 885                 890                 895    
 Gly Ser Arg Gln Asn Val Ser Ile Ser Thr Val Pro Asn Ala Val Thr
             900                 905                 910        
 Ser Leu Ser Lys Gln Asp Trp Thr Asn Ser Thr Ile Ala Leu Arg Trp
         915                 920                 925            
 Thr Ala Pro Gln Gly Pro Gly Gln Ser Ser Tyr Ser Tyr Trp Val Ser
     930                 935                 940                
 Trp Val Arg Glu Gly Met Thr Asp Pro Arg Thr Gln Ser Thr Ser Gly
 945                 950                 955                 960
 Thr Asp Ile Thr Leu Lys Glu Leu Glu Ala Gly Ser Leu Tyr His Leu
                 965                 970                 975    
 Thr Val Trp Ala Glu Arg Asn Glu Val Arg Gly Tyr Asn Ser Thr Leu
             980                 985                 990        
 Thr Ala Ala Thr Ala Pro Asn Glu Val Thr Asp Leu Gln Asn Glu Thr
         995                1000                1005            
 Gln Thr Lys Asn Ser Val Met Leu Trp Trp Lys Ala Pro Gly Asp Pro
    1010                1015                1020                
 His Ser Gln Leu Tyr Val Tyr Trp Val Gln Trp Ala Ser Lys Gly His
1025                1030                1035                1040
 Pro Arg Arg Gly Gln Asp Pro Gln Ala Asn Trp Val Asn Gln Thr Ser
                1045                1050                1055    
 Arg Thr Asn Glu Thr Trp Tyr Lys Val Glu Ala Leu Glu Pro Gly Thr
            1060                1065                1070        
 Leu Tyr Asn Phe Thr Val Trp Ala Glu Arg Asn Asp Val Ala Ser Ser
        1075                1080                1085            
 Thr Gln Ser Leu Cys Ala Ser Thr Tyr Pro Asp Thr Val Thr Ile Thr
    1090                1095                1100                
 Ser Cys Val Ser Thr Ser Ala Gly Tyr Gly Val Asn Leu Ile Trp Ser
1105                1110                1115                1120
 Cys Pro Gln Gly Gly Tyr Glu Ala Phe Glu Leu Glu Val Gly Gly Gln
                1125                1130                1135    
 Arg Gly Ser Gln Asp Arg Ser Ser Cys Gly Glu Ala Val Ser Val Leu
            1140                1145                1150        
 Gly Leu Gly Pro Ala Arg Ser Tyr Pro Ala Thr Ile Thr Thr Ile Trp
        1155                1160                1165            
 Asp Gly Met Lys Val Val Ser His Ser Val Val Cys His Thr Glu Ser
    1170                1175                1180                
 Ala Gly Val Ile Ala Gly Ala Phe Val Gly Ile Leu Leu Phe Leu Ile
1185                1190                1195                1200
 Leu Val Gly Leu Leu Ile Phe Phe Leu Lys Arg Arg Asn Lys Lys Lys
                1205                1210                1215    
 Gln Gln Lys Pro Glu Leu Arg Asp Leu Val Phe Ser Ser Pro Gly Asp
            1220                1225                1230        
 Ile Pro Ala Glu Asp Phe Ala Asp His Val Arg Lys Asn Glu Arg Asp
        1235                1240                1245            
 Ser Asn Cys Gly Phe Ala Asp Lys Tyr Gln Gln Leu Ser Leu Val Gly
    1250                1255                1260                
 His Ser Gln Ser Gln Met Val Ala Ser Ala Ser Glu Asn Asn Ala Lys
1265                1270                1275                1280
 Asn Arg Tyr Arg Asn Val Leu Pro Tyr Asp Trp Ser Arg Val Pro Leu
                1285                1290                1295    
 Lys Pro Ile His Glu Glu Pro Gly Ser Asp Tyr Ile Asn Ala Ser Phe
            1300                1305                1310        
 Met Pro Thr Val Gly Asp Phe Trp Arg Leu Val Trp Glu Gln Gln Ser
        1315                1320                1325            
 His Thr Leu Val Met Leu Thr Asn Cys Met Glu Ala Gly Arg Val Lys
    1330                1335                1340                
 Cys Glu His Tyr Trp Pro Leu Asp Ser Gln Pro Cys Thr His Gly His
1345                1350                1355                1360
 Leu Arg Val Thr Leu Val Gly Glu Glu Val Met Glu Asn Trp Thr Val
                1365                1370                1375    
 Arg Glu Leu Leu Leu Leu Gln Val Glu Glu Gln Lys Thr Leu Ser Val
            1380                1385                1390        
 Arg Gln Phe His Tyr Gln Ala Trp Pro Asp His Gly Val Pro Ser Ser
        1395                1400                1405            
 Pro Asp Thr Leu Leu Ala Phe Trp Arg Met Leu Arg Gln Trp Leu Asp
    1410                1415                1420                
 Gln Thr Met Glu Gly Gly Pro Pro Ile Val His Cys Ser Ala Gly Val
1425                1430                1435                1440
 Gly Arg Thr Gly Thr Leu Ile Ala Leu Asp Val Leu Leu Arg Gln Leu
                1445                1450                1455    
 Gln Ser Glu Gly Leu Leu Gly Pro Phe Ser Phe Val Arg Lys Met Arg
            1460                1465                1470        
 Glu Ser Arg Pro Leu Met Val Gln Thr Glu Ala Gln Tyr Val Phe Leu
        1475                1480                1485            
 His Gln Cys Ile Leu Arg Phe Leu Gln Gln Ser Ala Gln Ala Pro Ala
    1490                1495                1500                
 Glu Lys Glu Val Pro Tyr Glu Asp Val Glu Asn Leu Ile Tyr Glu Asn
1505                1510                1515                1520
 Val Ala Ala Ile Gln Ala His Lys Leu Glu Val
                1525                1530    



      <210> 1820
      <211> 611
      <212> PRT
      <213> Homo sapiens


      <400> 1820
 Met Ala Ala Val Ile Leu Ile Ile Thr Thr Thr Thr Lys Ile Ile Ile
   1               5                  10                  15    
 Ile Phe Ile Ile Thr Thr Ser Phe Ile Leu Tyr His His His His His
              20                  25                  30        
 Tyr Tyr Tyr His Ser Ser Leu Leu His His Val Ile Val Val Ile Thr
          35                  40                  45            
 Ile Asn Thr Ile Ile Phe Ala Ile Val Thr Thr Asp Ile Ile Ile Leu
      50                  55                  60                
 Cys Leu Tyr His His His His His Pro His Asp Arg Cys His His Gln
  65                  70                  75                  80
 His His His His Pro His Val Leu Ile Thr Ile Ile Met Ser Ile Ile
                  85                  90                  95    
 Phe Ile Ile Val Val Ile Ile Gly Ile Leu Ile Thr Thr Ile Thr Ala
             100                 105                 110        
 Ile Ile Ile Phe Ile Thr Thr Ile Ile Ile Ile Thr Ile Leu Ile Ala
         115                 120                 125            
 Ile Thr Thr Thr Asn Val Ala Gly Gln Ala Ser Ser Arg Ile Gly Phe
     130                 135                 140                
 Ser Leu Gly Gly Ser His Phe Asp Gln Gln Gly Cys Asp Gln Lys Thr
 145                 150                 155                 160
 Ser Pro Ala Ser Leu Leu Pro His Leu Ile Leu Thr Ile Ile Val Ile
                 165                 170                 175    
 Ile Ile Leu Val Thr Thr Ile Thr Ser Leu Leu Phe Ile Ile Pro Cys
             180                 185                 190        
 His His Phe His Tyr His His His Cys Tyr Cys His His Phe His Tyr
         195                 200                 205            
 Cys His Arg His Arg Ile Ile Val Val Ile Val Phe Ile Ser Thr Thr
     210                 215                 220                
 Ile Ile Thr Ile Phe Ile Ser Thr Thr Ile Thr Thr Phe Ile Ile Phe
 225                 230                 235                 240
 Pro Ala Thr Ser Thr Phe Thr Phe Ile Arg Val Leu Ile Val Ile Val
                 245                 250                 255    
 Ile Val Leu Val Pro Thr Thr Asp Leu Glu Glu Leu Glu Lys Gly Leu
             260                 265                 270        
 Gln Val Lys Leu Ser Asn Thr Glu Met Ser Gly Ala Gly Asp Ser Glu
         275                 280                 285            
 Tyr Ile Thr Leu Ala Asp Val Glu Lys Lys Glu Arg Glu Tyr Ser Glu
     290                 295                 300                
 Gln Leu Ile Asp Asn Met Glu Ala Phe Trp Lys Gln Met Ala Asn Ile
 305                 310                 315                 320
 Gln His Phe Leu Val Asp Gln Phe Lys Cys Ser Ser Ser Lys Ala Arg
                 325                 330                 335    
 Gln Leu Met Met Thr Leu Thr Glu Arg Met Ile Ala Ala Glu Gly Leu
             340                 345                 350        
 Leu Cys Asp Ser Gln Glu Leu Gln Ala Leu Asp Ala Leu Glu Arg Thr
         355                 360                 365            
 Met Gly Arg Ala His Met Ala Lys Val Ile Glu Phe Leu Lys Leu Gln
     370                 375                 380                
 Val Gln Glu Glu Thr Arg Cys Arg Leu Ala Ala Ile Ser His Gly Leu
 385                 390                 395                 400
 Glu Leu Leu Ala Gly Glu Gly Lys Leu Ser Gly Arg Gln Lys Glu Glu
                 405                 410                 415    
 Leu Leu Thr Gln Gln His Lys Ala Phe Trp Gln Glu Ala Glu Arg Phe
             420                 425                 430        
 Ser Arg Glu Phe Val Gln Arg Gly Lys Asp Leu Val Thr Ala Ser Leu
         435                 440                 445            
 Ala His Gln Val Glu Gly Thr Ala Lys Leu Thr Leu Ala Gln Glu Glu
     450                 455                 460                
 Glu Gln Arg Ser Phe Leu Ala Glu Ala Gln Pro Thr Ala Asp Pro Glu
 465                 470                 475                 480
 Lys Phe Leu Glu Ala Phe His Glu Val Leu Glu Arg Gln Arg Leu Met
                 485                 490                 495    
 Gln Cys Asp Leu Glu Glu Glu Glu Asn Val Arg Ala Thr Glu Ala Val
             500                 505                 510        
 Val Ala Leu Cys Gln Glu Gln Ala Lys Ile Leu His Cys Arg Leu Glu
         515                 520                 525            
 Ser Trp Leu Arg Pro Pro Gly Trp Ala Ser Leu Gly Gln Ser Leu Asp
     530                 535                 540                
 Cys Ser Glu Leu Trp Phe Pro Ser Leu Cys Asn Gly Asp Trp Glu Pro
 545                 550                 555                 560
 Ile Tyr Phe Lys Gly Trp Val Cys Arg Gly Glu Gln Val Gln Gly Pro
                 565                 570                 575    
 Asp Leu Ala His Gly Ser Met Ile Ser Gly Asp Val Glu Pro Ser Gly
             580                 585                 590        
 Asp Glu Pro Arg Ser Gly Ser Arg Val Leu Gly Val Asn Leu Asn His
         595                 600                 605            
 Gln Asn Glu
     610    



      <210> 1821
      <211> 532
      <212> PRT
      <213> Homo sapiens


      <400> 1821
 Met Gln Trp Ser Cys Ile Glu Val Val Val Cys Ile Glu Glu Leu Val
   1               5                  10                  15    
 Leu Leu Pro Gly Cys Ala Gln Asn Pro Trp Arg Lys Cys Arg Glu Thr
              20                  25                  30        
 Lys Cys Arg Ile Cys Glu Pro Leu Glu Leu Val Val Ser Val Ala Ser
          35                  40                  45            
 Asp Ala Glu Cys Cys Cys Ser Pro Leu Asn Phe Asn Val Ser Arg Asp
      50                  55                  60                
 Pro Leu Gln Thr Ile Ala Gly Met Ile Leu Pro Gly Leu Ala Tyr Ser
  65                  70                  75                  80
 Glu Arg Gln Gln Ser Val Ser Leu Arg Gly Ser Leu Ser Arg Gly Asn
                  85                  90                  95    
 Glu Ser Arg Ala His Thr Pro Thr Ser Phe Tyr Gly Ala Val Thr Leu
             100                 105                 110        
 Arg Ala Thr Val Thr Cys Pro Val Thr Gln Gly His Asn His Gly Gln
         115                 120                 125            
 Pro Trp Ala Leu Pro Arg Ala Thr Glu Ile Ile Pro Ala Asp Ala Tyr
     130                 135                 140                
 Ser Pro Pro Pro Val Val Thr Ala Lys His Val Ser Lys Asn Trp Gln
 145                 150                 155                 160
 Met Ser Pro His Gly Lys Ile Phe Pro Gly Gly Glu Pro Gln Ile Leu
                 165                 170                 175    
 Thr Cys Arg Ile Phe Pro Arg Ile Ile Glu Glu Ser Asp Val Ala Ala
             180                 185                 190        
 Thr Asp Thr Pro Ala Ser Gln Arg Cys Asp Val Ser Lys Gly Asn Val
         195                 200                 205            
 Glu Thr Val Asn Pro Trp Ser Trp Gln Val Leu Trp Cys Gln Ile Ser
     210                 215                 220                
 Asn Thr Ala Val Ser Asp Ala Phe Asn Val Lys Val Pro Arg Ile Ser
 225                 230                 235                 240
 Leu Gln Arg Ser Ser Gln Arg Cys Leu Gln Pro Leu Glu Ile Val Thr
                 245                 250                 255    
 Thr Phe Leu Gln Val Cys Leu Ser Trp Val Asn Gln Pro Val Leu Ala
             260                 265                 270        
 Tyr Thr Pro Ser His Thr Leu Trp Ser Ser Glu Pro Gln Ser Thr Cys
         275                 280                 285            
 Thr Val Thr Gln Gly Asp Ser Pro Cys Ser Ser Pro Gly Cys Ala Val
     290                 295                 300                
 Pro Ser Thr Cys Asp Tyr Glu Gln Gln Thr Phe Leu Leu Met Ala Ala
 305                 310                 315                 320
 Gly Pro Arg Thr Ala Ser Gly Cys Val Ile Met Ile Cys Phe Ala Leu
                 325                 330                 335    
 Thr Val Leu Ser Tyr Ile Arg Ile Leu Ala Thr Val Val Gln Ile Arg
             340                 345                 350        
 Ser Ala Ala Ser Arg Arg Lys Ala Phe Ser Thr Cys Ser Ser His Leu
         355                 360                 365            
 Gly Met Val Leu Leu Phe Tyr Gly Thr Gly Ser Ser Thr Tyr Met Arg
     370                 375                 380                
 Pro Thr Thr Arg Tyr Ser Pro Leu Glu Gly Arg Leu Ala Ala Val Phe
 385                 390                 395                 400
 Tyr Ser Ile Leu Ile Pro Thr Leu Asn Pro Leu Ile Tyr Ser Leu Arg
                 405                 410                 415    
 Asn Gln Asp Met Lys Arg Ala Leu Trp Lys Leu Tyr Leu Gln Val Leu
             420                 425                 430        
 His Asp Arg Thr Pro Pro Ser Ser Ala Ala Ser Ser Ile Thr Leu Ser
         435                 440                 445            
 Pro Ala Ala Phe Ile Pro Ser Tyr Ala Gly Leu Ser Ser Val Leu Gln
     450                 455                 460                
 Ala Asn His Ser Ser Pro Tyr Leu Gly Ala Leu His Leu Leu Phe Arg
 465                 470                 475                 480
 Gln Leu Lys Tyr Pro Ser Pro Asn Leu Ser Ile Thr Ala Ser Ala Tyr
                 485                 490                 495    
 Leu Ser Phe Ile Leu Asp Val Val Ser Leu Glu Arg Pro Leu Leu Thr
             500                 505                 510        
 Thr Ser Leu Ser Gly Ile Ile Pro Ser Pro Ser Arg Thr Ser Pro Arg
         515                 520                 525            
 Phe Ile Ala Phe
     530        



      <210> 1822
      <211> 714
      <212> PRT
      <213> Homo sapiens


      <400> 1822
 Met Ala Ala Val Leu Ala Leu Arg Val Val Ala Gly Leu Ala Ala Ala
   1               5                  10                  15    
 Ala Leu Val Ala Met Leu Leu Glu His Tyr Gly Leu Ala Gly Gln Pro
              20                  25                  30        
 Ser Pro Leu Pro Arg Pro Ala Pro Pro Arg Arg Pro His Pro Ala Pro
          35                  40                  45            
 Gly Pro Gly Asp Ser Asn Ile Phe Trp Gly Leu Gln Ile Ser Leu Phe
      50                  55                  60                
 Asn Thr Cys Phe Arg Gln Ile Ser Asp Ile His Leu Ser Arg Phe Arg
  65                  70                  75                  80
 Asp Pro Gly Arg Ala Val Asp Leu Glu Lys Phe Cys Ser Glu Thr Ile
                  85                  90                  95    
 Asp Ile Ile Gln Pro Ala Leu Val Leu Ala Thr Gly Asp Leu Thr Asp
             100                 105                 110        
 Ala Lys Thr Lys Glu Gln Leu Gly Ser Arg Gln His Glu Val Glu Trp
         115                 120                 125            
 Gln Thr Tyr Gln Gly Ile Leu Lys Lys Thr Arg Val Met Glu Lys Thr
     130                 135                 140                
 Lys Trp Leu Asp Ile Lys Gly Asn His Asp Phe Ala Arg Gln Pro Gln
 145                 150                 155                 160
 Lys Asp Asp Trp Gly Gln Gly Ser Cys Val Leu Phe Asn Glu Thr His
                 165                 170                 175    
 Asn Val Ala Val Thr Val Phe Leu Leu Leu Gln Glu His Gly Arg Gln
             180                 185                 190        
 Ile Gln Leu Leu Ile Tyr Cys Leu His Arg Gly His Leu Leu Gly Leu
         195                 200                 205            
 Leu Leu Pro Lys Ile Leu Leu Gln Asn Leu Val Leu Phe Trp Ser Gly
     210                 215                 220                
 Pro Leu Gln Thr Leu Asn His Gln Pro Ala Ala Phe Val Val Leu Asp
 225                 230                 235                 240
 Val Ser Ala Asn Phe Gly Gly His Ile Gly Val Pro Lys Glu Leu Gln
                 245                 250                 255    
 Glu Gly Arg Arg Ser Arg Asn Cys Leu Val Arg Asp Thr Arg Phe Val
             260                 265                 270        
 Pro Leu Phe Ser Glu Ser Ala Lys Ile His Ile Ala Leu Gly Gly Tyr
         275                 280                 285            
 Asp Glu Ile Gln Gly Leu Pro Asn Leu Ser Leu Ile Glu Thr Leu Pro
     290                 295                 300                
 Glu Glu Leu Asp Gln Val Gln Lys Lys Met Glu Glu Leu Leu Leu Leu
 305                 310                 315                 320
 Ala Lys Glu Ser Ser Arg Ser Asn His Thr Ile Trp Phe Gly His Phe
                 325                 330                 335    
 Thr Thr Ser Thr Ile Leu Ser Pro Ser Pro Gly Ile Arg Ser Ile Met
             340                 345                 350        
 Arg Tyr Arg Ile Phe Ala Phe Asp His Asp Leu Phe Ser Phe Ala Asp
         355                 360                 365            
 Leu Ile Phe Gly Lys Trp Pro Val Val Leu Ile Thr Asn Pro Lys Ser
     370                 375                 380                
 Leu Leu Tyr Ser Cys Gly Glu His Glu Pro Leu Glu Arg Leu Leu His
 385                 390                 395                 400
 Ser Thr His Ile Arg Val Leu Ala Phe Ser Leu Ser Ser Ile Thr Ser
                 405                 410                 415    
 Val Thr Val Lys Ile Asp Gly Val His Leu Gly Gln Ala Val His Val
             420                 425                 430        
 Ser Gly Pro Ile Phe Val Leu Lys Trp Asn Pro Arg Asn Tyr Ser Ser
         435                 440                 445            
 Gly Thr His Asn Ile Glu Val Ile Val Gln Asp Ser Ala Gly Arg Ser
     450                 455                 460                
 Lys Ser Val His His Ile Phe Ser Val Gln Glu Asn Asn His Leu Ser
 465                 470                 475                 480
 Phe Asp Pro Leu Ala Ser Phe Ile Leu Arg Thr Asp His Tyr Ile Met
                 485                 490                 495    
 Ala Leu Val Asp Ser Ser Asp Gly Pro Gly Ser Tyr Phe Glu Lys Gln
             500                 505                 510        
 Ala Pro Arg Ser Tyr Val Thr Ile Val Asn Ser Ser Pro Ala Ile Ser
         515                 520                 525            
 Val Gln Gly Gly Ala Pro Ser Pro Val Ile Leu Gln Leu Leu Gln Pro
     530                 535                 540                
 Tyr Val Gly Leu Val Gly Leu Glu Gly Asp Leu Ala Gly Ser Gln Asp
 545                 550                 555                 560
 Asn Ser Gly Gly Lys Arg Lys Glu Ser Leu Phe Glu Leu His Cys Leu
                 565                 570                 575    
 Glu Ser Trp Gly Met Gly Asp Thr Ser Thr Pro Leu Ala Thr Thr Thr
             580                 585                 590        
 Gly Val Ser Leu Gly Leu Val His Ser Ile Ser Thr Gly Ser Glu Pro
         595                 600                 605            
 Asn Ile Val Pro Arg Phe Ala Gln Gly Leu Gln Ser Leu Trp Leu Asp
     610                 615                 620                
 Cys Leu Ser Ser Leu Phe Arg Thr Leu Gly His Leu Phe Ser Gln Leu
 625                 630                 635                 640
 Val Leu Glu Leu Ala Gly Thr Gln Val Pro Thr Thr Gly Ala Glu Asp
                 645                 650                 655    
 Cys Pro Leu Ala Arg Ala Ser Leu Asn Ala Pro Ser Val Gly Ala Gly
             660                 665                 670        
 Arg Ile Leu Pro Cys Val Val Phe Pro Cys Asp Ser Thr Glu Phe Gln
         675                 680                 685            
 Arg Lys Val Ser Gln Ser Phe Cys Ser Leu Pro Gln Val His Arg Leu
     690                 695                 700                
 Ser Leu Pro Gln Asn Gly Gly Arg Val Val
 705                 710                



      <210> 1823
      <211> 552
      <212> DNA
      <213> Homo sapiens


      <400> 1823
 aagggtacgg gcagattgag attacagaag gatcccactg gttgccttgt gtgaggaccc     60
 agggagaagg gggaggctgt ccctgtttga gtaggagatg agagctactg gtggctatga    120
 gtggaaagaa gtgagcagag gtgagcagaa atcccaagga ctggtgatga taggatgatg    180
 gtgggaacca ggatgggctt tgggcagacc ctgacccctc tctctgcctg tcggcccacc    240
 agataataat ccctgtgttc ctgggcgagt cagtgccacc cgagatgttg gcggccactt    300
 tggctgagct ggacggatgc ctgcagctgc tcgaggacaa gttcctgcgg gaccaggcct    360
 tccttactgg gccccgtatc tctgtggctg gcttggtggc aatcacggag ctgaggcatg    420
 agagtgccat ggggtgcggt ggcccgctgg gcagtggtgt atccgggaag ggagctgaca    480
 tcccagctca tgttgtcttt tctggctgtg ggaccctgtg tgagtcactt ctccttctga    540
 gcctcgaatt cc                                                        552



      <210> 1824
      <211> 2193
      <212> DNA
      <213> Homo sapiens


      <400> 1824
 atgagttgtg atacaaatgg agaagtggag gggggaaggg tagacagcaa aacaagaggc     60
 aggcaagaag tagaaaggaa cacagaaact catctgggct ctggactcaa ctgtgatatt    120
 ccactgatat ttttaacata tgaatggagg gggatcctgg aatacaagat tttcagtgtt    180
 aagactggag aagttctggg taaaccagga caacttggtc atcctactgg tcaaacaaca    240
 ttttttgaaa ctgggaccca ggtcacgtcg atgcaagaga tgggctccta cagctttggg    300
 cagccccacc ctgtggcttt gcagggtaca gctccactcc ccgctgcttt caccggctgg    360
 cgtttagcgt ctgtggcttt tccaggcaca cagtgcaagc tgtctgtgga tctaccaatc    420
 tggggtctgg aggacagtgg ccctcttctc acagctccac ttggcagtgc cccagtgggg    480
 cctctgtgtg ggggttctga ccccacattt cccttctgca ctgccctaac aggaccctca    540
 gctgcaagtc tgttggagtt tgctagaggt ccactccaga ccctgtttgc ctgggtatca    600
 gcagaggtgt ctgcagaaca ggggtttttc gtgaaccacg aatgctgctg tctgatcgtt    660
 cctctggaag ttttgtctca gaggagtacc cggccctgtg aggtgtcagt ctgcccctac    720
 tggggggtgc ctcccagaga tcgcagtaat cagtgcccct ccgggtttac cttagactca    780
 gttggacctt tttgtgctga tgaggatgaa tgtgcagcag ggaatccctg ctcccatagc    840
 tgccacaatg ccatggggac ttactactgc tcctgcccta aaggcctcac catagctgca    900
 gatggaagaa cttgtcaaga tattgatgag tgtgctttgg gtaggcatac ctgccacgct    960
 ggtcaggact gtgacaatac gattggatct tatcgctgtg tggtccgttg tggaagtggc   1020
 tttcgaagaa cctctgatgg gctgagttgt caagatatta atgaatgtca agaatccagc   1080
 ccctgtcacc agcgctgttt caatgccata ggaagtttcc attgtggatg tgaacctggg   1140
 tatcagctca aaggcagaaa atgcatggat gtgaacgagt gtagacaaaa tgtatgcaga   1200
 ccagatcagc actgtaagaa cacccgtggt ggctataagt gcattgatct ttgtccaaat   1260
 ggaatgacca aggcagaaaa tggaacctgt attggtgagt gtctggctgt ttccgtgact   1320
 gagatcagtt tgccgtcaac aagtcaaata ttgatgaatg taaagatggg acccatcagt   1380
 gcagatataa ccagatatgt gagaatacaa gaggcagcta tcgttgtgta tgcccaagag   1440
 gttatcggtc tcaaggagtt ggaagaccct gcatggatat tgatgaatgt gaaaatacag   1500
 atgcctgcca gcatgagtgt aagaatacct ttggaagtta tcagtgcatc tgcccacctg   1560
 gctatcaact cacacacaat ggaaagacat gccaaggaaa actgccattt aaacaaattg   1620
 aaagtggggg gggccagtaa ggaaaaggaa aagagtgatg attttcttga aaaaggagaa   1680
 aaaaatctgg gtattattaa ggtgaccaaa agggttgcca atgtcctgat gctttggaaa   1740
 tctttggatt ccatacatct agaccctttt ggaacatcag tgaattatct agattctgca   1800
 ttcagaaata taagaaacct tggcatagtg tcagtgactt ctacagatat cagttcttta   1860
 tatgccaagg cacagcatgt tgcccggcgt cactacggat gtaacattgt ccgaactgaa   1920
 tattacaagg aactagcagc cagaattgtt gtagctgcag tggcaagtgt atctgtggaa   1980
 tttgcaggct cagaggactg tcatagcaat atacaagatg aaggtttgct cctcgcagct   2040
 ctgctagatg tcatgaagga gggtttcccc accctgccgt gtatcctaag ggaactttca   2100
 gggttggtga ttgatctcat tgcctacctc tgctcaacca ctggcatgct taagataaat   2160
 ttcaaggaaa tgttgtcaga agtacttggt taa                                2193



      <210> 1825
      <211> 794
      <212> DNA
      <213> Homo sapiens


      <400> 1825
 tttttttttt tggttatttt tttttgaatg aggaagctct cttcatttat ttcatatgag     60
 gatgaagaag aggattatgt gatcacagga atgttgcatg cgggataatc caaagctggt    120
 tatctccagg ccctcactct gccaagagat ctctctggaa gaagcagcca gttcacagat    180
 gccctggatc cctccgtgcc caatcataaa aaagtcatga ccgtccctat cttgccaatc    240
 tgccaggact ccaaggggaa aaagcggata agtatccggt cctggcccag ggctagctcc    300
 ttggtgagaa actcaaagaa gtgggcgctg tggctgcggt tgtcctcggc ggtgcccact    360
 acgccgatgg aggagatgga cagctgcgcg cagggctcgg tggacccgct cagcgccatg    420
 gccaggcccg gccgtaccgt cacgttcacg cggtccgcag gtttgcccag gatggaggca    480
 gcggcggcgc agagtcgttt ctccagcccc gcgggcactc ggttggcggg caaattcgtg    540
 tccagctcca ggaacggcat ggcgggcaga ggaacggaaa cagctcctca gatgtccgtg    600
 cgctggggcc tttccaggac ggcggcgccc agtcgtttct gggtcagggc gacgcctgga    660
 actgggcagg gtccctggca ccgggatccc gaaaagcaga catgcttctc cctgtccaga    720
 aggttcccct tcaccttgca gtcggccccc tgcatccgtg tcctcacgaa atcgtcgacc    780
 cgggaagtcc ggtc                                                      794



      <210> 1826
      <211> 794
      <212> DNA
      <213> Homo sapiens


      <400> 1826
 tttttttttt tggttatttt tttttgaatg aggaagctct cttcatttat ttcatatgag     60
 gatgaagaag aggattatgt gatcacagga atgttgcatg cgggataatc caaagctggt    120
 tatctccagg ccctcactct gccaagagat ctctctggaa gaagcagcca gttcacagat    180
 gccctggatc cctccgtgcc caatcataaa aaagtcatga ccgtccctat cttgccaatc    240
 tgccaggact ccaaggggaa aaagcggata agtatccggt cctggcccag ggctagctcc    300
 ttggtgagaa actcaaagaa gtgggcgctg tggctgcggt tgtcctcggc ggtgcccact    360
 acgccgatgg aggagatgga cagctgcgcg cagggctcgg tggacccgct cagcgccatg    420
 gccaggcccg gccgtaccgt cacgttcacg cggtccgcag gtttgcccag gatggaggca    480
 gcggcggcgc agagtcgttt ctccagcccc gcgggcactc ggttggcggg caaattcgtg    540
 tccagctcca ggaacggcat ggcgggcaga ggaacggaaa cagctcctca gatgtccgtg    600
 cgctggggcc tttccaggac ggcggcgccc agtcgtttct gggtcagggc gacgcctgga    660
 actgggcagg gtccctggca ccgggatccc gaaaagcaga catgcttctc cctgtccaga    720
 aggttcccct tcaccttgca gtcggccccc tgcatccgtg tcctcacgaa atcgtcgacc    780
 cgggaagtcc ggtc                                                      794



      <210> 1827
      <211> 2739
      <212> DNA
      <213> Homo sapiens


      <400> 1827
 cctgcaagtg tcacccccag ggctcagtcg gatccagctg cagccgactt ggaggccagt     60
 gccagtgtaa acctcttgtg gtcgggcgct gctgtgacag gtgctcaact ggaagctatg    120
 atttggggca tcacggctgt cacccatgtc actgccatcc tcaaggatca aaggacactg    180
 tatgtgacca agtaacagga cagtgcccct gccatggaga ggtgtctggc cgccgctgtg    240
 atcgctgcct ggcaggctac tttggatttc ccagctgcca cccttgccct tgtaataggt    300
 ttgctgaact ttgtgatcct gagacagggt catgcttcaa ttgtggaggc tttacaactg    360
 gcagaaactg tgaaaggtgt attgatggtt actatggaaa tccttcttca ggacagccct    420
 gtcgtccttg cctgtgtcca gatgatccct caagcaatca gtattttgcc cattcctgtt    480
 atcagaatct gtggagctca gatgtaatct gcaattgtct tcaaggttat acgggtactc    540
 agtgtggaga atgctctact ggtttctatg gaaatccaag aatttcagga gcaccttgcc    600
 aaccatgtgc ctgcaacaac aacatagatg taaccgatcc agagtcctgc agccgggtaa    660
 caggggagtg ccttcgatgt ttgcacaaca ctcagggcgc aaactgccag ctctgcaaac    720
 caggtcacta tggatcagcc ctcaatcaga cctgcagaag atgctcctgc catgcttccg    780
 gcgtgagtcc catggagtgt ccccctggtg ggggagcttg cctctgtgac cctgtcactg    840
 gtgcatgtcc ttgtctgccg aatgtcacag gcctggcctg tgaccgttgt gctgatggat    900
 actggaatct ggtccctggc agaggatcat gtgattgtaa cagggcaggt acccagaagc    960
 ccatctgtga tccagacaca ggcatgtgcc gctgccggga gggtgtcagc ggccagagat   1020
 gtgatcgctg tgcccgggga cacagccagg aattccctac ttgtcttcaa tgtcacttgt   1080
 gctttgatca gtgggaccac accatttctt ccctctccaa agcggtgcaa gggttaatga   1140
 gactggctgc taacatggaa gataaaagag agaccctgcc tgtctgtgag gcagacttca   1200
 aagacctcag agggaacgtg tctgaaatag aaaggatttt gaaacatcct gttttcccat   1260
 ctgggaaatt cttaaaagtc aaggattatc atgactctgt tagaagacaa atcatgcagc   1320
 taaatgaaca actgaaagca gtgtatgaat ttcaagatct gaaagataca atagaaagag   1380
 caaagaatga agcagacctc ttacttgaag accttcagga agaaattgat ttgcaatcca   1440
 gtgtccttaa tgcaagcatt gcggactcct cagaaaacat caagaaatat tatcacatat   1500
 catcatctgc tgaaaagaaa attaatgaaa ctagttccac cattaatacc tctgcaaata   1560
 caaggaatga cttacttacc atcttagata cactaacctc aaaaggaaac ttgtcattgg   1620
 aaagattaaa gcagattaag ataccagata tccaaatatt gaatgaaaag gtgtgcggag   1680
 atccaggaaa tgtgccatgt gtgcccttgc cctgtggcgg tgctctctgc acgggccgga   1740
 aggggcacag gaagtgtagg ggtcccggct gtcacggctc cctgaccctc tcaacgaatg   1800
 ccctccaaaa agcccaggaa gcaaaatcca ttattcgtaa tttggacaaa caggttcgtg   1860
 ggttgaaaaa tcagatcgaa agtataagtg aacaggcaga agtctccaaa aacaatgcct   1920
 tacagctgag ggaaaaactg ggaaatataa gaaaccaaag tgactctgaa gaagaaaaca   1980
 tcaatctttt catcaaaaaa gtgaaaaact ttttgttaga ggaaaacgtg cctccagaag   2040
 acatcgagaa ggttgcgaat ggtgtgcttg acattcacct accaattcca tcccaaaatc   2100
 taaccgatga acttgtcaaa atacagaaac atatgcaact ctgtgaggat tacaggacag   2160
 atgaaaacag gttaaatgaa gaagcagatg gagcccaaaa gcttttggtg aaggccaaag   2220
 cagctgagaa agcagcaaat attctattaa atcttgacaa aacattgaac cagttacaac   2280
 aagctcaaat cactcaagga cgggcaaact ctaccattac acagctgact gccaatataa   2340
 caaaaataaa aaagaatgtg ctgcaggaat ttgttgagct gaaaaaacaa tatgctattc   2400
 tccaacgtaa gacaagcact acaggactaa caaaggagac attaggaaaa gttaaacagc   2460
 taaaagatgc ggcagaaaaa ttggctggag atacagaggc caagataaga agaataacag   2520
 atttagaaag taaaatccaa gatttgaatc taagtagaca agcaaaagct gatcaactga   2580
 gaatattgga agatcaagtt gttgccatta aaaatgaaat tgttgaacaa gaaaaaaaat   2640
 atgctaggtg ctatagctag gcagagttaa agagcaaaag cttgtgcctt tgtttctggt   2700
 ttctgatgta caagcccctg gggctctgtt gaacctgtg                          2739



      <210> 1828
      <211> 2723
      <212> DNA
      <213> Homo sapiens


      <400> 1828
 atgggctcgg ggcgcgtacc cgggctctgc ctgcttgtcc tgctggtcca cgcccgcgcc     60
 gcccagtaca gcaaagccgc gcaagatgtg gatgagtgtg tggaggggac tgacaactgc    120
 cacatcgatg ctatctgcca gaacaccccg aggtcataca agtgcatctg caagtctggc    180
 tacacagggg acggcaaaca ctgcaaagac gtggatgagt gcgagcgaga ggataatgca    240
 ggttgtgtgc atgactgtgt caacatccct ggcaattacc ggtgtacctg ctatgatgga    300
 ttccacctgg cacatgacgg acacaactgt ctggatgtgg acgagtgtgc cgagggcaac    360
 ggcggctgtc agcagagctg tgtcaacatg atgggcagct atgagtgcca ctgccgggaa    420
 ggcttcttcc tcagcgacaa ccagcatacc tgtatccagc ggccagaaga aggaatgaat    480
 tgcatgaaca agaaccacgg ctgtgcccac atttgccggg agacacccaa ggggggtatt    540
 gcctgtgaat gccgtcctgg ctttgagctt accaagaacc aacgggactg taaatgtgag    600
 ataattggga tggcagtgac atgcaactat ggtaacggcg gctgccagca cacgtgtgat    660
 gacacagagc agggtccccg gtgcggctgc catatcaagt ttgtgctcca taccgacggg    720
 aagacatgca tcgagacctg tgctgtcaac aacgggggct gtgacagtaa gtgccatgat    780
 gcagcgactg gtgtccactg cacctgccct gtgggcttca tgctgcagcc agacaggaag    840
 acgtgcaaag atatagatga gtgccgctta aacaacgggg gctgtgacca tatttgccgc    900
 aacacagtgg gcagcttcga atgcagttgc aagaaaggct ataagcttct catcaatgag    960
 aggaactgcc aggatataga cgagtgttcc tttgatcgaa cctgtgacca catatgtgtc   1020
 aacacaccag gaagcttcca gtgtctctgc catcgtggct acctgttgta tggtatcacc   1080
 cactgtgggg atgtggatga atgcagcatc aaccggggag gttgccgctt tggctgcatc   1140
 aacactcctg gcagctacca gtgtacctgc ccagcaggcc agggtcggct gcactggaat   1200
 ggcaaagatt gcacagagcc actgaagtgt cagggcagtc ctggggcctc gaaagccatg   1260
 ctcagctgca accggtctgg caagaaggac acctgtgccc tgacctgtcc ctccagggcc   1320
 cgatttttgc cagagtctga gaatggcttc acggtgagct gtgggacccc cagccccagg   1380
 gctgctccag cccgagctgg ccacaatggg aacagcacca actccaacca ctgccatgag   1440
 gctgcagtgc tgtccattaa acaacgggcc tccttcaaga tcaaggatgc caaatgccgt   1500
 ttgcacctgc gaaacaaagg caaaacagag gaggctggca gaatcacagg gccaggtggt   1560
 gccccctgct ctgaatgcca ggtcaccttc atccacctta agtgtgactc ctctcggaag   1620
 ggcaagggcc gacgggcccg gacccctcca ggcaaagagg tcacaaggct caccctggaa   1680
 ctggaggcag agcaactctt tctcctccct gatacacacg gccatccacc accagccagc   1740
 tgtgggctgc cctgcctccg acagcgaatg gaacggcggc tgaaaggatc cctgaagatg   1800
 ctcagaaagt ccatcaacca ggaccgcttc ctgctgcgcc tggcaggcct tgattatgag   1860
 ctggcccaca agccgggcct ggtagccggg gagcgagcag agccgatgga gtcctgtagg   1920
 cccgggcagc accgtgctgg gaccaagtgt gtccagtgct ccccagggca ctactacaac   1980
 accagcatcc accgctgtat tcgctgtgcc atgggctcct atcagcccga cttccgtcag   2040
 aacttctgca gccgctgtcc aggaaacaca agcacagact ttgatggctc taccagtgtg   2100
 gcccaatgca agaatcgtca gtgtggtggg gagctgggtg agttcactgg ctatattgag   2160
 tcccccaact acccgggcaa ctacccagct ggtgtggagt gcatctggaa catcaacccc   2220
 ccacccaagc gcaagatcct tatcgtggta ccagagatct tcctgccatc tgaggatgag   2280
 tgtggggacg tcctcgtcat gagaaagaac tcatccccat cctccattac cacttatgag   2340
 acctgccaga cctacgagcg tcccattgcc ttcactgccc gttccaggaa gctctggatc   2400
 aacttcaaga caagcgaggc caacagcgcc cgtggcttcc agattcccta tgttacctat   2460
 gatgaggact atgagcagct ggtagaagac attgtgcgag atggccggct ctatgcctct   2520
 gaaaaccacc aggagatttt aaaggacaag aagctcatca aggccttctt tgaggtgcta   2580
 gcccaccccc agaactactt caagtacaca gagaaacaca aggagatgct gccaaaatcc   2640
 ttcatcaagc tgctccgctc caaagtttcc agcttcctga ggccctacaa atagtaaccc   2700
 taggctcaga gacccaattt ttt                                           2723



      <210> 1829
      <211> 1887
      <212> DNA
      <213> Homo sapiens


      <400> 1829
 ccgtttttgt tcttctaagc aaaagatctc cctctctcta gccgatgctc cccactcagt     60
 tcatcccggg aatgggccag ggaggaaggt tctcatgcat cgccccgagc tgccaggcga    120
 gcttcgggct ccttaaattc acaggccaac agcccgcgtc ctctccgcgc aggctcccgg    180
 ttgcccgcgg tccccggccc agctccttgg cctcctcctc gtcggtccgc ccctggtggt    240
 cttggcgccc gctcgtccag ctcggcgcgc cggggaccgc cggctgcccg gggcagtccg    300
 cacgccctcg gggatctcgg ctcccggatc cgccgcgccg gcaggagccg gccgggcctg    360
 gagggagcaa gcggatgcgc ccacgccccc ggcacgggga tggcgcgaca gggcccgggc    420
 tccggggtgg ggctcggcag agctcctgac agctccgggg ctcggcagcg cgggaggggg    480
 gagctccgcc gctcgccgct cattcccggc tcggggctcc cctccactcg ctcgggcggc    540
 gcggggcccg ttcgggccgc ccgtcgccgc ccccgccccc cgcgcgcccg cccgccagcc    600
 cgcctgcgcc ctcgctcgcc ccgcgcgcgt tcctagggcg ccacctcttt gcgactagct    660
 cacttctccg gcaggtttgc ctcggagcgt gtgaacattc ctccgctcgg ttttcaactc    720
 gcctccaacc tgcgccgccc ggccagcatg tctccccgcc cgtgaagcgg gctgccgcct    780
 ccctgccgct ccggctgcca ctaacgaccc gccctcgccg ccacctggcc ctcctgatcg    840
 acgacacacg cacttgaaac ttgttctcag ggtgtgtgga atcaactttc cggaagcaac    900
 cagcccacca gaggaggtcc cgagcgcgag cggagacgat gcagcggaga ctggttcagc    960
 agtggagcgt cgcggtgttc ctgctgagct acgcggtgcc ctcctgcggg cgctcggtgg   1020
 agggtctcag ccgccgcctc aaaagagctg tgtctgaaca tcagctcctc catgacaagg   1080
 ggaagtccat ccaagattta cggcgacgat tcttccttca ccatctgatc gcagaaatcc   1140
 acacagctga aatccacccc gtccgatttg ggtctgatga tgagggcaga tacctaactc   1200
 aggaaactaa caaggtggag acgtacaaag agcagccgct caagacacct gggaagaaaa   1260
 agaaaggcaa gcccgggaaa cgcaaggagc aggaaaagaa aaaacggcga actcgctctg   1320
 cctggttaga ctctggagtg actgggagtg ggctagaagg ggaccacctg tctgacacct   1380
 ccacaacgtc gctggagctc gattcacgga ggcattgaaa ttttcagcag agaccttcca   1440
 aggacatatt gcaggattct gtaatagtga acatatggaa agtattagaa atatttattg   1500
 tctgtaaata ctgtaaatgc attggaataa aactgtctcc cccattgctc tatgaaactg   1560
 cacattggtc attgtgaata tttttttttt tgccaaggct aatccaatta ttattatcac   1620
 atttaccata atttattttg tccattgatg tatttatttt gtaaatgtat cttggtgctg   1680
 ctgaatttct atattttttg taacataatg cactttagat atacatatca agtatgttga   1740
 taaatgacac aatgaagtgt ctctattttg tggttgattt taatgaatgc ctaaatataa   1800
 ttatccaaat tgattttcct ttgtgcatgt aaaaataaca gtattttaaa tttgtaaaga   1860
 atgtctaata aaatataatc taattac                                       1887



      <210> 1830
      <211> 627
      <212> DNA
      <213> Homo sapiens


      <400> 1830
 ttcccgggtc gacgatttcg tgctacaggc aggtgtatac cacggaggcc cggaccgtgc     60
 tcaggtgctg ccgagggtgg atgcagcagc ccgacgagga gggctgcctc tcggctgaat    120
 gcagcgccag cctctgtttt cacggtggcc gttgtgtgcc aggctcagcc cagccgtgtc    180
 actgtccccc cggcttccag ggaccccgct gtcagtatga tgtggacgaa tgccgaaccc    240
 acaacggtgg ctgccagcac cggtgcgtga acaccccagg ctcctacctc tgtgagtgca    300
 agcccggctt ccggctccac actgacagca ggtcctgcct ggccattaac tcctgcgccc    360
 tgggcaatgg cggctgccag caccactgtg tccagctcac aatcactcgg catcgctgcc    420
 agtgccggcc cgggttccag ctccaggagg acggcaggca ttgtgtccgt agaagcccgt    480
 gtgccaacag gaacggcagc tgcatgcaca ggtgccaggt ggtccggggc ctcgcccgct    540
 gtgagtgcca cgtgggctat cagctagcag cggacggcaa ggcctgtgaa gatgtggacg    600
 aatgtgccgc aaggctggcc cagtgtg                                        627



      <210> 1831
      <211> 423
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> misc_feature
      <222> (1)...(423)
      <223> n = a,t,c or g


      <400> 1831
 acaacacatg tgcaggatat gaaattgctg aggcatcact gctttcctac ttcccttcca     60
 agtctcagct cccttatttt aaaaaatatt tggcctcaat gatcatttct caacaattcc    120
 tcaccgcagg agcctctgaa gctcccacca ggccagctct cctcccacaa cagcttccca    180
 cagcatgaag atctccgtgg ctgccattcc cttcttcctc ctcatcacca tcaccctagg    240
 gaccaagact gaatcctcct cacggggacc ttaccacccc tcagagtgct gcttcaccta    300
 cactacctac aagatcccag cgcagcggat tatggattac tatgaaacca acagccagtg    360
 cttcaagccc ggaattgtct tcatcaccaa aaggggccat tcccgatgga ccaaccccaa    420
 ggn                                                                  423



      <210> 1832
      <211> 412
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> misc_feature
      <222> (1)...(412)
      <223> n = a,t,c or g


      <400> 1832
 atgaaggcac tcctggccct gccgctgctg ctgcttctct ccacgccccc gtgtgccccc     60
 caggtctccg ggatccgagg agatgctctg gagaggtttt gccttcagca acccctggac    120
 tgtgacgaca tctatgccca gggctaccag tcagacggcg tgtacctcat ctacccctcg    180
 ggccccagtg tgcctgtgcc cgtcttctgt gacatgacca ccgagggcgg gaagtggacg    240
 gttttccaga agagattcaa tggctcagta agtttcttcc gcggctggaa tgactacaag    300
 ctgggcttcg gccgtgctga tggagagtac tggctggggc tgcagaacat gcacctcctg    360
 acactgaagc agaagtatga gctgcgagtg gacttggagg actttgagaa cn            412



      <210> 1833
      <211> 1191
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> misc_feature
      <222> (1)...(1191)
      <223> n = a,t,c or g


      <400> 1833
 gttggggatc cagagccatg tcggacctgc tactactggg cctgattggg ggcctgactc     60
 tcttactgct gctgacgctg ctggcctttg ccgggggccc cctgataagt gccgatgtgc    120
 cgtgggcagc atcctgagtg aaggtgagga atcgccctcc cctgagctca tcgacctcta    180
 ccagaaattt ggcttcaagg tgttctcctt cccggcaccc agccatgtgg tgacagccac    240
 cttcccctac accaccattc tgtccatctg gctggctacc cgccgtgtcc atcctgcctt    300
 ggacacctac atcaaggagc ggaagctgtg tgcctatcct cggctggaga tctaccagga    360
 agaccagatc catttcatgt gcccactggc acggcaggga gacttctatg tgcctgagat    420
 gaaggagaca gagtggaaat ggcgggggct tgtggaggcc attgacaccc aggtggatgg    480
 cacaggagct gacacaatga gtgacacgag ttctgtaagc ttggaagtga gccctggcag    540
 ccgggagact tcagctgcca cactgtcacc tggggcgagc agccgtggct gggatgacgg    600
 tgacacccgc agcgagcaca gctacagcga gtcaggtgcc agcggctcct cttttgagga    660
 gctggacttg gagggcgagg ggcccttagg ggagtcacgg ctggaccctg ggactgagcc    720
 cctggggact accaagtggc tctgggagcc cactgcccct gagaagggca aggagtaacc    780
 catggcctgc accctcctgc agtgcagttg ctgaggaact gagcagactc tccagcagac    840
 tctccagccc tcttcctcct tcctctgggg gaggaggggt tcctgaggga cctgacttcc    900
 cctgctccag gcctcttgct aagccttctc ctcactgccc tttaggctcc cagggccaga    960
 ggagccaggg actattttct gcaccagccc ccagggctgc cgcccctgtt gtgtcttttt   1020
 ttcagactca cagtggagct tccaggaccc agaataaagc caatgattta cttgtttcac   1080
 ctggnnnnnn nnnnnnnngg gggggccgtt ttaaaggatc cttggggggg ccaaagctta   1140
 cgggggcagg caacggaata gttttttcct tatagggagc cgaattatac c            1191



      <210> 1834
      <211> 897
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> misc_feature
      <222> (1)...(897)
      <223> n = a,t,c or g


      <400> 1834
 tatttttttc ctaaaatttt gggccaaaaa aaatggcgcc tattttggcc cttaaaaatt     60
 tttaaaccga gggtccctgc ccaaaattga ctttaagggg gtttggtccc taaaaaaagg    120
 cccaaccgtg ttttaaatta aaaaaattta aatggggccc aatgcccccc tataagggac    180
 cctccggggg ttttccgcgt tcagcgttta aaaaattggg gattccgggc cggggcgagc    240
 tannnnnnnn nncttgtaac aaggcatttt atttgggatg aggaaaggaa attgagcaga    300
 aggtacagga gtaatagcaa ttccctgtag ctctcaaagt caaatttgga gctcattttt    360
 ctttttctgc aagctcagca gcaggaatgc cccaaagtct tcccctggta agatgcaggt    420
 tccataagcg acgttcctcc tgcaatgcac gctggtattc tgcaataagc aggccatgtt    480
 ttttccttga gcctgggatg ctttgggagc caaagctttt ggtcccatgc aaggggaaac    540
 aacccacttc tggggatgtc ccgctgcaat ctgctccggg ggctgcagca acctcatgca    600
 gctctttcct ggggacgcgg ctcaagcctg gggcctgcag ggcccaccag gggagaattg    660
 gcagcaagga gtggcgaggg tcctcatggg ctgggggtca cagatcctct agctacgcca    720
 gggtgaccag agagggcaga cagcagtcct ctgtcccagg tcttctatag caaggacctg    780
 atggagaagg tcaagagccc agagcttcag gccgaggcca agtcttactt tgaaaagtca    840
 aaggagcagc tgacacccct gatcaagaag ctggaacgga actggttaac ttcttga       897



      <210> 1835
      <211> 337
      <212> DNA
      <213> Homo sapiens


      <400> 1835
 ggaggatcgc agcgcatttc ggccaagaca gcctcacacg cttcaccctt tacacgcacg     60
 gtcacttgcc ccgcgcagcc ccaccccccc cagccctcct agccctgaca cacagctggg    120
 actctcaggt ccgaccagcg gtcctgaatc cgctcccacg gcacgggaaa tccttcgtgg    180
 cgaagcagca ggtggggaag cagcagcccc tgcgctgcct catctacata gaagtcgccc    240
 tatccgtgat gtcaccgaca gtgcctttcc cagtccccgt ctgcctttct gccgctcagc    300
 ctaccaaccc gctgccggag ccggcagggg gaagtga                             337



      <210> 1836
      <211> 2890
      <212> DNA
      <213> Homo sapiens


      <400> 1836
 atggatcctg aggtgacctt gctgctgcag tgccctggcg ggggcctgcc ccaggagcag     60
 atacaggccg agctgagccc cgcccatgac cgtcgcccac tgccaggtgg ggacgaggcc    120
 atcactgcca tctgggagac ccggctaaag gcccaaccct ggctcttcga cgcccccaag    180
 ttccgcctgc actcagccac cctggcgcct attggctctc gggggccaca gctgctcctg    240
 cgcctgggcc ttacttccta ccgagacttc ctgggcacca actggtccag ctcagctgcc    300
 tggctgcgac agcagggtgc caccgactgg ggtgacacgc aggcctatct ggcggaccca    360
 ctgggggtgg gcgctgcact agccacagcc gatgacttcc ttgtcttcct gcgccgctcc    420
 cggcaggtgg ctgaggcccc tgggctggtg gacgtacctg gtgggcaccc tgagcctcag    480
 tcctgtgaga aactagaaaa cacgggagga aagattgggc acaggaagaa gatgccctac    540
 tccacccctg ccccctgtgt atctcctttg aagctggacc tctggttgtc tgtcagggaa    600
 aggacaccag actcaggatc actaactctc ttacactgtg ccacatcaga ccctcaaggc    660
 cagcaggccc tgtgccctgg tggcagcccc cagcaccagg acctcgctgg gcagctggtg    720
 gtacatgaac tcttttccag tgtccttcag gagatctgtg atgaggtgaa cctgccgctg    780
 ctcaccctga gccagcccct gctgttgggc atcgcccgaa atgagaccag tgctggccga    840
 gccagtgccg agttctatgt ccagtgcagc ctgacttctg agcaggtgag gaagcactac    900
 ctgagtgggg gacccgaggc ccacgagtct acaggaatct tctttgtgga gacacagaac    960
 gtgcggagat tgcccgagac ggagatgtgg gctgaactct gcccctcggc caaaggcgcc   1020
 atcatcctct acaaccgggt ggacgtggtc ttggcatcca cgccaatgag aatctgcccg   1080
 cccgccgcca tgccgccctt actgcccctg cgcctgtgcc ggctgtggcc ccgcaaccct   1140
 ccctcccggc tcctcggagc ggccgccggg cagcggtcca gacccagtac ttattatgaa   1200
 ctgttggggg tgcatcctgg tgccagcact gaggaagtta aacgagcttt cttctccaag   1260
 tccaaagagc tgcacccaga ccgggaccct gggaacccaa gcctgcacag ccgctttgtg   1320
 gagctgagcg aggcataccg tgtgctcagc cgtgagcaga gccgccgcag ctatgatgac   1380
 cagctccgct caggtagtcc cccaaagtct ccacgaacca cagtccatga caagtctgcc   1440
 caccaaacac acagcagctc ctggacaccc cccaacgcac agtactggtc ccagtttcac   1500
 agcgtgaggc cacaggggcc ccagttgagg cagcagcaac acaaacaaaa caaacaagtg   1560
 ctggggtact gcctcctcct catgctggcg ggcatgggcc tgcactacat tgccttcagg   1620
 aaggtgaagc agatgcacct taacttcatg gatgaaaagg atcggatcat cacagccttc   1680
 tacaacgaag cccgggcacg ggccaggtct gtccctgctc tattctgctc cctgctccct   1740
 gtccaggaac cacacttcgg gatccctatc ccaaccaccc aggcccctgt ctcccagcct   1800
 gatgcccctg gccaccagag gaaagtggtg tcatggatag atgtgtatac tcgcgctacc   1860
 tgccagcccc gggaggtggt ggtgcccttg actgtggagc tcatgggcac cgtggccaaa   1920
 cagctggtgc ccagctgcgt gactgtgcag cgctgtggtg gctgctgccc tgacgatggc   1980
 ctggagtgtg tgcccactgg gcagcaccaa gtccggatgc aggtactggg cacgtggggc   2040
 aacgggcagg ggatgcagat cctcatgatc cggtacccga gcagtcagct gggggagatg   2100
 tccctggaag aacacagcca gtgtgaatgc agacctaaaa aaaaggacag tgctgtgaag   2160
 ccagacagcc ccaggcccct ctgcccacgc tgcacccagc accaccagcg ccctgacccc   2220
 cggacctgcc gctgccgctg ccgacgccgc agcttcctcc gttgccaagg gcggggctta   2280
 gagctcaacc cagacacctg caggtttagc tgcctctcaa ctgcaggttc attacttcag   2340
 ttgacagatg tttggtggct gctggggcgc ctgaaaataa gtctggtggg ggaacaggcc   2400
 cagccagatc attccagtca tgagtcacag cccaggtgca caggtagagt actgtccatc   2460
 tgcctgagcg ccgtggccac ggccacgggg gccgagggca aaaggaagct gcagatcggg   2520
 gtcaagaagc gggtggacca ctgtcccatc aaatcgcgca aaggggatgt cctgcacatg   2580
 cactacacgg ggaagctgga agatgggaca gagtttgaca gcagcctgcc ccagaaccag   2640
 ccctttgtct tctcccttgg cacaggccag gtcatcaagg gctgggacca ggggctgctg   2700
 gggatgtgtg agggggaaaa gcgcaagctg gtgatcccat ccgagctagg taagaggccc   2760
 ctcctgaggg tgcagagcga gtttggggtg tgtgactggg aagggtgaaa gctgcttcag   2820
 cttttcattg gtcttcaccg tatccatttc attacaatac atgcctcctc caagtttggg   2880
 ctgtgtctag                                                          2890



      <210> 1837
      <211> 310
      <212> DNA
      <213> Homo sapiens


      <400> 1837
 cctgaaaaaa atatatttat ctatttttct agaaccaagg aagaataata atatattata     60
 agaacacaga cacaaatatc ccaccatccc cttcattata ttttgggatc tgctaaaaaa    120
 aaactatgtt tcggcaaaag ctattttata agaggaagca gcttcagaaa gggccaaggc    180
 catgaggagc ggggtttaaa gtataaaaaa aaaactgggg aaggggttta atgaaagaga    240
 acaaagaaac aaacaaaaac aaaaacaaaa accattaaat acaaacttag caggtgctgt    300
 ggaaatgtgc                                                           310



      <210> 1838
      <211> 507
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> misc_feature
      <222> (1)...(507)
      <223> n = a,t,c or g


      <400> 1838
 cctctactga aggctactct tcttatcaag taacgtcttc tccatgctct tgacccttgc     60
 cccttcagac ctatggatgg taataacctg cccacaccta gtttaccatc agaggacaca    120
 gcagcacgtg tgccatccta gaagcataga gcagaccctt accagacaac caaccagctg    180
 gtnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn ncacccctac tctgtccaga    240
 cccaactgtc aacagaagcc aaagccatct ggaggagcat gcaacaacaa gaaacaaatt    300
 tattagctaa cctaaccact aatgacgcaa gagacaattc taaggacttt caaaacagca    360
 aagtaggagc agctgctacc tctagggatg agggagaaac tcaaaaatgc atacaaaaac    420
 cattgcatga aaagtgactg gatttgtaca tagcgtcagg agatgtgcgt agtgtcaaag    480
 tatctcatca cacattactt gataatg                                        507



      <210> 1839
      <211> 1780
      <212> DNA
      <213> Homo sapiens


      <400> 1839
 cggtggaatt cgatggatgc ctgcaacagg tacagcaagc tgaattgctt agtggcgccc     60
 acactcttcc tggagttcca tggctcccag caggcactgg aggagcagct gcagcgcaca    120
 gaggagatag tccagcagaa cggagcctct gacttctcct gggccaagga ggccgaggag    180
 cgcagccggc tttggacagc acggcacaat gcctggtacg cagccctggc cacgcggcca    240
 ggctgcaagg gctactccac ggatgtgtgt gtgcccatct cccggctgcc ggagatcgtg    300
 gtgcagacca aggaggatct gaatgcctca ggactcacag gaagcattgt cgggcatgtg    360
 ggtgacggca acttccactg catcctgctg gtcaaccctg atgacgccga ggaactgggc    420
 agggtcaagg cttttgcaga acagctgggc aggcgggcac tggctctcca cggaacgtgc    480
 acgggggagc atggcatcgg aatgggcaag cggcagctgc tgcaggagga ggtgggcgcc    540
 gtgggcgtgg agaccatgcg gcagctcaag gccgtgctag acccccaagg cctcatgaat    600
 ccaggcaaag tgctgtgaag ggggtctgag cacttagccc acaagttccc tgactacgga    660
 gccggttctg gaacttttct tcatgccacg gcccctgcaa ggaaatagat gctgaggcag    720
 tcttcctgcc agcgagccca ctgtatctgg gcccaaggcc agagggccca gagagaagcc    780
 tgagcaccgt gttacctccc tggccctctg gctggccccc aggagccttt ggttcaagta    840
 aacgacccca gggtggttcc ccagcaaagc tgcttcctct ctgctcctac gcatcctgtc    900
 ctggcgggaa gagagcgtct gggtccattc aagactctga tgacacccct ccccgaggcc    960
 tcccactgcc ggggtcccag gacccttccc ccttcacctg gtgacaggaa cactcctttc   1020
 ctggtatgga acgtgagctc ccgtgacatg atgataggtc ttctccttgg ggcctccccc   1080
 aataaatctg taataaacct gaaacccacc tacagctacc tggaagtcag caggcagcac   1140
 ttcctcccct ccccctccag ggtctctgtc ctttggtcag tgaccccttt gttttggggc   1200
 tgtcctctga cttcttatag cctggggagg aggttggtgc tcagggttcg gaaaggaacc   1260
 caggtccctg tcccagctac tccgcctcag agctgaggac ctgcccacgg cacatgtcac   1320
 tcaggatggg ctccccaact gggcctgaac cgggcctctg aacacactga atgtgttcct   1380
 cagcagctgc cacgtctcta gaaacagaga tgagactatt tttgcaccca cctcttcatg   1440
 gggtgatgta tcgtaccacc agctgttttg ccctcaaggt ctgtccaccc gagggcctgc   1500
 ccctgtcttg ggccggagcc cgtcttgaga ccttggcagt tgttcccccc taagcccaca   1560
 ggagggcgcc cgaaatcatg aagctcagat accacgcggc atctgcagct cacgactcct   1620
 ctgcccaggg cctgcggcac tcagccctgg gcaaacctcc tcctatggtc aggtaagtcc   1680
 tggcagcctg gaagccaagc tagtcctcca tcccctgcag gtcccaggaa cctgcagtgc   1740
 tgtctcatct tccttgcccc tctagccttc ggtccctttg                         1780



      <210> 1840
      <211> 1094
      <212> DNA
      <213> Homo sapiens


      <400> 1840
 ggaattcaca gagattcccc gcccgggtcc ccgccaacgg cgctagccgc gatgccccgc     60
 ctcactcccc gcccccggga tgcacggcgc gtgctggtaa tccgcggctc aagccccgcc    120
 cccactgtcc ccattctccg ctcacctctc tccaaggaca ctgcgcacgc gccacgacgt    180
 cccgcctttc tccccgccct gccgcggccc cggggcgcag cgcgcacgca atcgcgtttc    240
 cggagagacc tggctgctgt gtcccgcggc ttgcgctccg tagtggactc cgcgggcctt    300
 cggcagatgc aggcctgggg tagtctcctt tctggactga gaagagaaga atggagaagc    360
 ccctcttccc attagtgcct ttgcattggt ttggctttgg ctacacagca ctggttgttt    420
 ctggtgggat cgttggctat gtaaaaacag gcagcgtgcc gtccctggct gcagggctgc    480
 tcttcggcag tctagccggc ctgggtgctt accagctgta tcaggatcca aggaacgttt    540
 ggggtttcct agccgctaca tctgttactt ttgttggtgt tatgggaatg agatcctact    600
 actatggaaa attcatgcct gtaggtttaa ttgcaggtgc cagtttgctg atggccgcca    660
 aagttggagt tcgtatgttg atgacatctg attagcagaa gtcatgttcc agcttggact    720
 catgaaggat taaaaatctg catcttccac tattttcaat gtattaagag aaataagtgc    780
 agcatttttg catctgacat tttacctaaa aaaaaaaaga caccaaattt ggcggagggg    840
 gggaaaatca gttgttacca ttataaccct acaaaggggg ggagcatgta acatgagctt    900
 attgagacca tcataaagac cgattcttga tattgatttt atctctttct gtatctatag    960
 ggaaacctca agggtaaaat gttaggggtt gacattgaaa accctgaaac cccattccct   1020
 gctcaaagga acagtgtgaa aaaaaatctc ttgagagatt aaaaatatct ttttttttgc   1080
 tcatcttaaa ccac                                                     1094



      <210> 1841
      <211> 1697
      <212> DNA
      <213> Homo sapiens


      <400> 1841
 tttcgtgtgg tgggctgcgg gtaggggagg ggatggaccg agtcccggct tgtcgggatg     60
 agggttccgg aagatctggc cagtaagatt ctactccctg gctgtgcacc gggttcccta    120
 cccctgtcta cgtcggctcc gccacttcgc ggcttgagac taaaagagca tcccggcagg    180
 gggccttcca gccccaaagc agcctgtcca gagaccccca aattctgatc ctgaagttgg    240
 aggcctccgg ggatgttctt ttttaatctt ttaaaagggt tagaggggtt gaggctgcct    300
 gaccccagcc taatggggta ggtaggcctt gggaagtgga gcatgggggc aaaggatcca    360
 agcattgagc cttcatcctc tattccccat ccagtggggt gccgaggctc aggcagcatg    420
 acgacggaga cctttgtgaa ggatatcaag cctgggctca agaatctgaa ccttatcttc    480
 attgtgctgg agacaggccg agtgaccaag acaaaggacg ggcatgaggt tcggacctgc    540
 aaagtggcgg acaaaacagg cagcatcaat atctctgtct gggacgatgt tggcaatctg    600
 atccagcctg gggacattat ccggctcacc aaagggtacg cttcagtttt caaaggttgt    660
 ctgacactat atactggccg tgggggtgat ctgcagaaga ttggagaatt ctgtatggtt    720
 tattctgagg ttcctaactt cagtgagcca aacccagagt acagcaccca gcaggcaccc    780
 aacaaggcgg tgcagaacga cagcaaccct tcagcttccc agcctaccac tggaccctct    840
 gctgcctctc cagcctctga gaaccagaat gggaatggac tgagtgcccc accaggtccc    900
 ggtggtggcc cacatccccc tcatactccc tcccacccac ccagcacccg aatcactcga    960
 agccagccca accacacacc tgcaggcccg cctggccctt ccagcaaccc tgttagtaac   1020
 ggcaaagaaa cccggaggag cagcaagaga tagcatgaca ttctttcttc ctgccaccaa   1080
 ccacatccca agtgtcccct ggagagcaag atagccttcc actgattggc tggtgtagca   1140
 gtattttagc cactgaactt cagtggaggg tggtgagcag tgtccttatc caccctaatc   1200
 tcatactccc tcattgtcca gctgaactac ctgtcccctg ggagtcagga ccctctgcct   1260
 gctctctttc ctctttagaa atggcagtta ctggctgggc gcagtggctc acgcttgtaa   1320
 tcccagcact ttgggaagcc gaggtgggcg gatcacctga ggtcgggagt tcaagaccag   1380
 cctgaccaac atggagaaac cccgtgtcta ctaaaaatac agaattagcc aggcatggtg   1440
 gcgtatgcct gtaatcccag ctacttagga ggctgaggca ggagaatctc ttgaaaccgg   1500
 gaggcggagg ttgaggtgag ccgaaattgc accattgcac tccagcctgg gcaataagag   1560
 cgaaactcca tctcaaaaaa aaaagaaaga aagaaagaaa gaaagaaaga aatggcagtt   1620
 accatctgtt tcttctgtgt gagacatggg agtctaactg aagtctctcc ttcctaataa   1680
 atgttaccac ttctaaa                                                  1697



      <210> 1842
      <211> 647
      <212> DNA
      <213> Homo sapiens


      <400> 1842
 atggtggaag gggaagcaaa cacgtccttc ttcacgtggc agcagcaagg agaagtgccg     60
 agcaaagagg gaaaagcccc ttataaaacc atcagctctc gtgagaactc actcactatc    120
 atgagaacgg catgagagta accaccccca tgattaaatt actcccgggt accttccacg    180
 acacatgcgg attgtgggaa ctacaagagg aatttggcac tgcgaggttc tctgccgagg    240
 ccaaccagaa ataccccttg gaagctggaa tctgcaacaa tggcccaggg tgtcctctgg    300
 atcctactcg gattgctact gggtcagacc cagggacagg atgcccggcc atccaccccc    360
 ctgccgctgg ggagcggcgc cttatcgggg ccgcccgaag ctgctgcagt gccgctggga    420
 ttcttgtacg tgcatcacac ctacgtgcct gcaccacctg cacggacttc acgcgctgcg    480
 cagccaacat gcgctccatg cagcgctcca ccaggacacg caaggctggg gagacatcgg    540
 ctacagttcg tggtgggctc ggacggctac gtgtacgagg gacgcggctg gcactggtgg    600
 gcgcccacac gctcggccac aactcccggg gcttcggcgt ggcctag                  647



      <210> 1843
      <211> 400
      <212> DNA
      <213> Homo sapiens


      <400> 1843
 tgctcgtgtg gatatgatca cagctgagta catgggcttg tgcgtgcaca agaatagaaa     60
 aggatgtgca tgtttgtgca tgcacgagga cacacagagc acacgagcac ccacaggaca    120
 catagacaag ccaaagggca ctcatgtgtg ggggtcaaac atctgagagc gtgtgaccag    180
 tgtgagtctg aagaccatag actctagtga caggtgtctg agatggccac gggctgcatt    240
 agaaacacta agaggctcac tgcctgctct gtccccattg gatccctcgg caggctccag    300
 tgacagcaaa ctgtggcatg gagcccccag aggacctagc acttaacctt ggagcttccc    360
 tgagtcctca ccttgaagag agtccctgga ccaatgtcca                          400



      <210> 1844
      <211> 570
      <212> DNA
      <213> Homo sapiens


      <400> 1844
 atgggctcca aggcaaagaa gcgcgtgctg ctgcccaccc gcccagcgcc ccccacggtg     60
 gagcagatcc tggaggatgt gcggggtgcg ccggcagaga aaacagtgtt caccatcctg    120
 gccccggaag accccccagt tcccttcagg atgatggagg atgcggaggc cccgggagag    180
 cagctctacc agcaaagccg ggcctacgtg gctgccaacc agcggctgca gcaggcgggc    240
 aacgtgctga gccagaggag tgagctcctg cagcgagccg gcgtggacct gggtcgggag    300
 gtggaactga tgaacattga gcagaaaaaa aagactgatg gaaacgaaaa gaaattggag    360
 aaagttaaag cttaccggga gaagattgag aaggagctgg agacagtttg caatgatgtc    420
 ctgtctctgc ttgacaagtt cctgatcaag aactgcaatg atttccagta tgagagcaag    480
 gtgttttaca tgaaaatgaa gggtgattac taccgctact tagctaagat gccatgtgca    540
 ggtggattcc atgccgcaga catgaaataa                                     570



      <210> 1845
      <211> 1135
      <212> DNA
      <213> Homo sapiens


      <400> 1845
 ggggcagagg gaataagagg ctgcctctgc ccaccagtcc tgccgcccag gacccgcagc     60
 agagacgacg cctgcagcaa ggagaccagg aaggggtgag acaaggaaga ggatgtctga    120
 gctggagaag gccatggtgg ccctcatcga cgttttccac caatattctg gaagggaggg    180
 agacaagcac aagctgaaga aatccgaact caaggagctc atcaacaatg agctttccca    240
 tttcttagag gaaatcaaag agcaggaggt tgtggacaaa gtcatggaaa cactggacaa    300
 tgatggagac ggcgaatgtg acttccagga attcatggcc tttgttgcca tggttactac    360
 tgcctgccac gagttctttg aacatgagtg agattagaaa gcagccaaac ctttcctgta    420
 acagagacgg tcatgcaaga aagcagacag caagggcttg cagcctagta ggagctgagc    480
 tttccagccg tgttgtagct aattaggaag cttgatttgc tttgtgattg aaaaattgaa    540
 aacctctttc caaaggctgt tttaacggcc tgcatcattc tttctgctat attaggcctg    600
 tgtgtaagct gactggcccc agggactctt gttaacagta acttaggagt caggtctcag    660
 tgataaagcg tgcaccgtgc agcccgccat ggccgtgtag accctaaccc ggagggaacc    720
 ctgactacag aaattacccc ggggcaccct taaaacttcc actaccttta aaaaacaaag    780
 ccttatccag cattatttga aaacactgct gttctttaaa tgcgttcctc atccatgcag    840
 ataacagctg gttggccggt gtggccctgc aagggcgtgg tggcttcggc ctgcttcccg    900
 ggatgcgcct gatcaccagg tgaacgctca gcgctggcag cgtcctggaa aaagcaactc    960
 catcagaact cgcaatccga gccagctctg ggggctccag cgtggcctcc gtgacccatg   1020
 cgattcaagt cgcggctgca ggatccttgc ctccaacgtg cctccagcac atgcggcttc   1080
 cgagggcact accgggggct ctgagccacc gcgagggcct gcgttcaata aaaag        1135



      <210> 1846
      <211> 279
      <212> DNA
      <213> Homo sapiens


      <400> 1846
 tgacaggaag ggaagtgccc tggctgggca tcaagagact tttctggccc tttccctgcc     60
 aacactttgc tgtgtgacct tggctcccgc ctcggcctgc ctcctgctga tgctcctggc    120
 cctgcccctg gcggccccca gctgccccat gctctgcacc tgctactcat ccccgcccac    180
 cgtgagctgc caggccaaca acttctcctc tgtgccgctg tccctgccac ccagcactca    240
 gcgactcttc ctgcagaaca acctcatccg cacgctgcg                           279



      <210> 1847
      <211> 1098
      <212> DNA
      <213> Homo sapiens


      <400> 1847
 tgagagtctt gctttgcccc ctaggttgga gtgcagcagc acaatcttgg cttactgcaa     60
 cctccgcctc ccaggttcaa gtgattcttg tgcctcagcc tctcaagtag ctgggattac    120
 aggcatgggc catcatgcct ggctaatttt tatattttta atggagacat ggtttcacta    180
 tgttggccag gttggtcttg aactcctgac cttgtgatct gcctgccttg gcctcctaaa    240
 gtgctgggat tacaagcatg agccactgca tccagactct ccttgttgcc ttatttattt    300
 gagacgcagt ctcgctctgt cgcccaggct ggagtgcagt ggcttgatct cggctcactg    360
 actccagcct gggtgacaga actgaaaaaa aataacataa aacatagata cagaaaacca    420
 caaaggacaa acacagcata ttgaatcatc acaaggcagc caccccttca tagccacacc    480
 tggcccctgg ccaccactga cctgtgctcc atcgcgcaga attccgttgt ctcaggaatg    540
 ttcgatgaat ggaatcctgt gtggcctgag atgagtgtct ttcatgccac gtaacaatct    600
 tgaggcccgt gaaagctgtt ggtatgtcaa cagttagctg cttctcattg ctgagtggcg    660
 attggtcctg tcatggttta ttcagccatg tggtggatgg ctacttgtct tctaagccac    720
 ttgccttctg attgctggac tgactctctc gccctctctt ggtgcagccc tcgggaggct    780
 cagtcacact ctccgagagc acagccatca tctcccacga catcacaggc ctggtcacat    840
 gagatgctgc cctctacctg gcagaatggg ccatcgagaa cccggcagcc ttctctcata    900
 ggtgacctcg gggcgcacgg caggacaccg aggcaggctc accctggtgc agtcacagac    960
 atggtcccct ttcctcccgc caggactgtc ctagagcttg gcagtggcgc cagcctcaca   1020
 ggcctggcca tctgcaagat gtgccgcctc caggcataca tcttcagcga ctgtcacagc   1080
 caggtcctcg acccggga                                                 1098



      <210> 1848
      <211> 1120
      <212> DNA
      <213> Homo sapiens


      <400> 1848
 caaggctgta ggagttctgg agctgctggc tggagaggag ggtggacgaa gctctctcta     60
 gaaagacatc ctgagaggac ttggcaggcc tgaacatgca ttggctgcga aaagttcagg    120
 gactttgcac cctgtggggt actcagatgt ccagccgcac tctctacatt aatagtaggc    180
 aactggtgtc cctgcagtgg ggccaccagg aagtgccggc caagtttaac tttgctagtg    240
 atgtgttgga tcactgggct gacatggaga aggctggcaa gcgactccca agcccagccc    300
 tgtggtgggt gaatgggaag gggaaggaat taatgtggaa tttcagagaa ctgagtgaaa    360
 acagccagca ggcagccaac gtcctctcgg gagcctgtgg cctgcagcgt ggggatcgtg    420
 tggcagtgat gctgccccga gtgcctgagt ggtggctggt gatcctgggc tgcattcgag    480
 caggtctcat ctttatgcct ggaaccatcc agatgaaatc cactgacata ctgtataggt    540
 tgcagatgtc taaggccaag gctattgttg ctggggatga agtcatccaa gaagtggaca    600
 cagtggcatc tgaatgtcct tctctgagaa ttaagctact ggtgtctgag aaaagctgtg    660
 atgggtggct gaacttcaag aaactactaa atgaggcatc caccactcat cactgtgtgg    720
 agactggaag ccaggaagca tctgccatct acttcactag tgggaccagt ggtcttccca    780
 agatggcaga acattcctac tcgagcctgg gcctcaaggc caagatggat gctggacact    840
 ctccagttat ccaatcaaga gtatgatggg tgcccccatt gtttaccgga tgttgctaca    900
 gcaggatctt tccaggtgat ggggctttga ggattggtaa gagagtctgg ccccatcccc    960
 ctgactccct cacatacatt catgcctatc tatctgaatc tctcgcacac agagagcccc   1020
 atgaagccat ttgcatcatc aaagcaccca gaaacccagt ctagtcctga gtggactttg   1080
 gttccaggga ggctgagggc aaacatttat ttctcttctt                         1120



      <210> 1849
      <211> 1555
      <212> DNA
      <213> Homo sapiens


      <400> 1849
 atgccgtatt cactaaacct ggccataagg gacacctttg tgaatgcctc tcggaccctg     60
 tacagcagca gccccagagt cctaagcaac aacagtgacg ccaacttgga gctcatcaac    120
 acctgggtgg ccaagaacac caacaacaag atcagccggc tgctagacag tctgccctcc    180
 gatacccgcc ttgtcctcct caatgctatc tacctgagtg ccaagtggaa gacaacattt    240
 gatcccaaga aaaccagaat ggaacccttt cacttcaaaa actcagttat aaaagtgccc    300
 atgatgaata gcaagaagta ccctgtggcc catttcattg accaaacttt gaaagccaag    360
 ttgagtcgtg gggacagctt gaaggagcca acctcaattg cagagagcag ccgtcacccc    420
 agctaccgct cagagcccag cttggaacca gagagcttcc gttctcctac ctttggcaaa    480
 agttttcact tcgatccact atccagtggc tcacgctcct ccagcctcaa gtcagcccag    540
 ggcacaggct ttgagctggg ccagttgcaa tccattcgtt cagagggcac cacctccacc    600
 tcctataaga gcctggccaa ccagacacgc aatggaagcc tatcttatga cagcttgctc    660
 acaccttcag acagccctga ttttgagtca gtgcaggcag ggcctgagcc agacccacct    720
 ttaggctata cctctccctt cctgtcagcc aggctggccc agcaacggga agctgagagg    780
 cacccacgtt tggtgccaac tggcccaaca caccgagagc cctcaccagt ccgttacgac    840
 aatctgtcgc gccacattgt ggcctctctc caggaacgag agaagttgct gcgccagtca    900
 cccccactcc cgggccgtga ggaagaacca ggcttggggg actcaggcat tcagtcaaca    960
 ccaggctcgg gccatgcccc tcgtactagt tcctcctcag atgattcaaa gagatcacct   1020
 ttggggcaag actccactgg gacggccagc tgttccccgt tttggcaagc cagatgggct   1080
 ataggggccg gggagtaggg ttccctgaac caggcccaac agccccatac ctgggccgat   1140
 cgatgtctta cagcagccaa atagcccaac ctggtgtctc tgagacagaa gaagtggact   1200
 tgcggccatt actgacaccc aaagatgaag tacagctgaa gaccacctac agcaaatcca   1260
 acgggcagcc caagagctta ggctcagcct cccctggccc aggccagcca cctctcagta   1320
 gccccacgag gggaggagtc aagaaggtgt caggggttgg tggtaccacc tatgagattt   1380
 cggaatttga tcatcactgc ccctgggtga ataactgtat tggtcgccgg aactaccgtt   1440
 attttttcct tttcctcctt tccctgacag cccacattat gggtgtgttt ggctttggcc   1500
 tcctttatgt cctctaccac atagaggaac tctcaggggt ccgcacggct gtcac        1555



      <210> 1850
      <211> 375
      <212> DNA
      <213> Homo sapiens


      <400> 1850
 ggcacgagga cacacccttg ttcattctcc ttgagaagca gctattatca acagaacatt     60
 gacagaacct gtgtttgggg aaaggactga tggctttgag tctaggttgg aaagcacaca    120
 ggaaccactg tggtctcctc ttgcaggctc tgcgaagcag tggtcttctc ttgtttccct    180
 gtggccagtg tccctggaga ggagctggaa gctttttgga ccctgagata aaggctttcc    240
 tggaggagaa cactgaagtc accagcagtg gtagcctcac ccctgaaatc cagttgcggc    300
 ttttgacccc cagatgcaaa ttctggtggg agagagctga cctgtggccc cacagtgatc    360
 cttactgggc aatct                                                     375



      <210> 1851
      <211> 1523
      <212> DNA
      <213> Homo sapiens


      <400> 1851
 tttttttttt ttgaaaaata aatgatttta ttgcagggcc aatgataggt agtcacaagg     60
 gcatgaaatg gcagatctct tgtctgaagc agagaaggca cactggcaga ctccatgtgt    120
 gtcaaacgct gtgcatgaat caggttttta gaaggaaggt aggagaggaa aactactcac    180
 tagcagaact gaactgctgt aaaataggtt aaattctttg aaaagtgaaa aatgatagta    240
 gcaaaatcat gaagttgtat ctgaaccaga gccgtgatgt aaccaagtaa gatggaagtt    300
 tccatccaga cgagttaatt cccgaacaag gtcacaggaa aggtgagacg ctgccggttc    360
 cggcacgcct gtcttctgga gtgccagtga ccgggcaaga aattttgatt ctttcctttg    420
 atactcttgg gaaagaacac atttcccaag cccctggaga cccacagggt ttggcactgt    480
 ccgtgaggct gtgctcctga ggacggacgt tcaggaggcc gtggaggagc agcgctgcag    540
 gagcagggtg tggcagctgt cgcacactcg caccggcttg gggtaggagg gcagggccag    600
 ctcgttgctg gagcaggtgt tgcagaagat gtggccacag ttccggcagt ggtgctttct    660
 ccgggaaatg gagaactcct tctcacactg cctacagtgt gtcgcttcgt catctttcag    720
 ccaggcgtgg cccttcagtg cctggttcac ttcttttata tcttccatct tcagcttgga    780
 ctggctgagg tgcaggccca tttcctggag ggcttgttcc tgctcctcgc agatcttctg    840
 cagctctgcc ttctcgtcct gaagctcccg caactccttt ttcagtcctt ccacttgttg    900
 cagctccatc ctgagtagag aggaagtgtc tttctcgtgc tgtaattcgc gctgaagagc    960
 ctgtctttgc tctttttctg atttcaattc tttctccagg cttgagcatt gctcgtgcag   1020
 ctgggagagc tgcagctgca gggcgccgat cctcccgccc agctcctgct gcagcttgtg   1080
 gctccgctcc tcagccccct gcctcgcccg ctccgagtgc tgcaaccttt cttccatttg   1140
 tttcatgctg gacataactt ggttggtttt tccttcaaag gatgtgatgg cttcattctt   1200
 ctgctgcaaa ctgctctctg cattctgagc tttgtgaaac atctgtaaat taatcgcttt   1260
 gacttcttcc agctgctggc ggagggcaac tagtgtgtcc tgcttctcgt gggtgtcctt   1320
 ttccagtaac ttcattgcaa tttccatttc ggttttcatt ccaatttgta actccagttc   1380
 tttttccagt tccaaccgga ctttcttctc ctcttttagc tgcttccaca catcactgta   1440
 catttcatcc agaccttgcc gagtttgctt gtaagtctcc agctcaactt tggtatcctg   1500
 ttttgttatc tctacactct ttt                                           1523



      <210> 1852
      <211> 1350
      <212> DNA
      <213> Homo sapiens


      <400> 1852
 atgaagagac tgttggagag aaggaactgg actcctcaag ctatgctcta cctgaaaggg     60
 gcacagggtc gccgcttcat ctccgaccag agccggagaa aggacctctc cgaccggcca    120
 ctgccggaaa gcgtctcctc accggaaaga cgcggctctg aggcgccctc agatacagtc    180
 cgcccgaggg cagcccgggt tggcagcagc agcagctgga tgccgagcgc cggagctggg    240
 agctcgcgcg tccagccccg cgccaatggt ggcaagggcg gcccaggctg gcgctgcggc    300
 tccccaagcc ttattggctt gcggctgttc agccagccct ctggctgcca ggaaagacga    360
 agcccaaatc cccaactact aactattccg gaggcagcaa ccatcttact ggcgtccctt    420
 cagaaatcac cagaagaaca attcagttct aaagccattt gggagggtgc tgtggaagtc    480
 cagagaaagg catcagagtc caagcagttt gagaaatgtc tacacaaaga ggagcagcct    540
 aaagcagtgt cagagccaga atggagagag gagggcatcc gtgcatgtga gggagtgtat    600
 ggagaaagat tagttacaca gaagaagatt gacccaatat gtagcaaatt aaaggtgatt    660
 ttgcacccag agtttctatc ctccaccagt cccttactac ccatggacta tgaagagttt    720
 gttagaggtt gtcatcttgg agtatttcca tcatactatg aaccctgggg ttatactcca    780
 ggaggactag ggccttttcc tcctctgagt gcatacaagg atataggcgc tggtctgaag    840
 ccaagctttg gtctatttcc cctggcagct gaatgcactg tgatgggtat ccccagtgtg    900
 accacgaatc tctccgggtt tggctgtttc atgcaggagc acgtggctga tcctactgct    960
 tacggtattt acatcgttga caggcggttc cgttctccag atgattcttg caatcagctg   1020
 actaagtttc tctatggatt ttgcaaacag tcacgccgcc aaaggattat ccagaggaac   1080
 agaactgaga ggctctcaga tcttctggat tggagatact taggcagaac agaaggattt   1140
 aaatatccca ggccttcctc agtaccacct tctccttcag ggtctcaggc ctccagtcct   1200
 cagagcagtg atgtggaaga tgaagtggag gatgagagat acgatgagga agaggaggct   1260
 gaaagggatc ggttaaatat caagtcacca ttttcactga gccacgttcc tcatgggaag   1320
 aaaaagctgc atggtgaata taagaactga                                    1350



      <210> 1853
      <211> 704
      <212> DNA
      <213> Homo sapiens


      <400> 1853
 agagagccct gcgggaactg cgtgagcgcg tgacccatgg cttggctgaa gccggcaggg     60
 accgcgagga cgtcagcacc gagctgtacc gggcgctgga ggccgtgagg ctgcagaaca    120
 gtgagggttc ctgtgagccg tgccctacgt cgtggctgcc cttcgggggc tcctgctact    180
 atttctctgt gccgaagacc acgtgggcag aggcgcaggg ccactgcgcc gatgccagcg    240
 cacatctggc gatgtagggg gcctggggga gcaggacttc ctgagtcgtg acactagtgc    300
 ccttgaatac tggatcggcc gcagggccgt gcaacacctg cgcaaggttc agggctactc    360
 gtgggtggac ggagtcccac tcagcttcag gtaggggaag ggctcctggt gaaacctggg    420
 ggccacaggt tagactctag aggacatgtt ttgaggccga ggtgggcgga tcacctgagg    480
 tcaggagttc aagaccagca tgggaaacgt ggcgaaaccc catctctact aaaaatacaa    540
 aaaattagcc gggcgtggtg gcacacgcct gtaatcccag ctaaccctgg atgctgaggc    600
 acgagaatca cttgaaccca ggaggcagag gttgcagtga gccgagattg cgccactgca    660
 ctccagcctg ggagacagag ttagactccg tctcaaaaaa aaaa                     704



      <210> 1854
      <211> 642
      <212> DNA
      <213> Homo sapiens


      <400> 1854
 gcaatattgg aggctgcatt tcagtttctg tcacccctcc agcagaattt gtttaaattt     60
 tgtctgtccc ttcgttctta ctcagctaca atccaagcct tccagcagat agcagctgat    120
 gaacctccac cagaaggatg taattcgttt ttttcagtgc atggaaagaa gacttgtgaa    180
 tctgataccc ttgaggctct tctactgaca gcctctgaaa gacccaaacc tttattgttc    240
 aaaggagatc acagatatcc ctcgtctaat cctgaaagcc ctgtggtgat tttctactct    300
 gagattggct ctgaggaatt ttccaatttt caccgccagc ttatatcaaa aagcaatgca    360
 ggcaaaatca actatgtatt cagacattat atatttaatc ccaggaagga gcctgtttac    420
 ctctctggct atggcgtgga attggccatt aagagcactg agtacaaggc caaggatgat    480
 actcaggtga aaggaactga ggtaaacacc acagtgattg gtgaaaatga tcctattgat    540
 gaggttcagg ggttcctctt tggaaaatta agagatctgc accccgacct ggagggacag    600
 ttgaaagaac tcagaaagca tcttgtagag agcacctgta tt                       642



      <210> 1855
      <211> 803
      <212> DNA
      <213> Homo sapiens


      <400> 1855
 agcttggcga cttgggggcc aggggccctg gggctgaagg gtccagggct gtgggcttct     60
 gggggagcct tcagagcttg atcaaggaaa gggattaggg gtaggggatg acaggggtct    120
 gtggctggag ggagctggga tgcaggaaat ggtctttggg tcgggtattc agggcctcgc    180
 ttcccctgag tcattctttc caccccctgg ccgcacgtgg acccaaggtg aggaagtctg    240
 ccctgagcca ggctctcgag gtcccggccc tcgcccccgc gcggggcctt agtgctcttg    300
 cccaccgaca gctctgggtg gatcgcccag tggcgcctgt ccgtgttttg gcgcccccta    360
 gcagcggcgc agttgcgcct gtttcgatag gcgagcggat tggcgcccct ggttgccgga    420
 gcaatccctt aggcctggtt ccctgccgcc tggagcctcg gctcctcgca gtcaggtggg    480
 ttctgggggt gccagcaggc tctgagagtg ccggccgcgg ggccctcgca gcttgcctgc    540
 tgcagtcgga gctggtaaac tacgagcgcg tgcgcgagta ctgtctcaag gtactggata    600
 aacatcaggg caacttcaag gccacctacc gtgccggcat tgccttctac cacctgggcg    660
 actacgcacg cgcgctgcgc tacctgcagg aggcccgcag ccgggaaccc acaggtgagt    720
 ggcggagcgc gccacacgag agggctgggc ccacggcggc gaaaggggct gcagcggaag    780
 gaacacgccc tatgattagg gcc                                            803



      <210> 1856
      <211> 618
      <212> DNA
      <213> Homo sapiens


      <400> 1856
 ggcacgagct cagatagtgc agttaactca gcaggtggac acaaatatat ctgttatttt     60
 acctactgtt catgaggggg atattttcag gtgtttctgc ccagttttcc ttcatagtca    120
 gatgctctgg gagctggtgc tgttggggga gccccttgtg gttatggcgc catcaccatc    180
 ggaatcatca gagactgtat tggcacttgt taactgtatt tctccattaa agtacttcag    240
 tgatttccga ccttatttca ctattcatga tagtgaattc aaagaatata ctacccgtac    300
 ccaagctccg ccctcagtta tattaggagt aaccaaccct ttttttgcta agacactcca    360
 gcactggcca cacattattc gaataggaga ccttaaacct acaggtgaaa ttcctaagca    420
 ggttaaagtg aaaaaactga agaatctaaa gactctggat tccaaacctg gagtttatac    480
 ttcatataag ccatattcta actagagatg aagagatcat acaacagcta cagaggggcg    540
 taccacacaa aacgcgcttt tgaggctcaa cagtggtatt cttcgacgct attttttgga    600
 actgacacaa agtttcag                                                  618



      <210> 1857
      <211> 1407
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> misc_feature
      <222> (1)...(1407)
      <223> n = a,t,c or g


      <400> 1857
 gtggccnatg aatgatagct gtacgaccgc cgnaccggnc cggaattccn nctcgacgat     60
 ttcgtgtgag cagaggccgg ccatggccag cctggggctg ctgctcctgc tcttactgac    120
 agcactgcca ccgctgtggt cctcctcact gcctgggctg gacactgctg aaagtaaagc    180
 caccattgca gacctgatcc tgtctgcgct ggagagagcc accgtcttcc tagaacagag    240
 gctgcctgaa atcaacctgg atggcatggt gggggtccga gtgctggaag agcagctaaa    300
 aagtgtccgg gagaagtggg cccaggagcc cctgctgcag ccgctgagcc tgcgcgtggg    360
 gatgctgggg gagaagctgg aggctgccat ccagagatcc ctccactacc tcaagctgag    420
 tgatcccaag tacctaagag agttccagct gaccctccag cccgggtttt ggaagctccc    480
 acatgcctgg atccacactg atgcctcctt ggtgtacccc acgttcgggc cccaggactc    540
 attctcagag gagagaagtg acgtgtgcct ggtgcagctg ctgggaaccg ggacggacag    600
 cagcgagccc tgcggcctct cagacctctg caggagcctc atgaccaagc ccggctgctc    660
 aggctactgc ctgtcccacc aactgctctt cttcctctgg gccagaatga gggggtgcac    720
 acagggacca ctccaacaga gccaggacta tatcaacctc ttctgcgcca acatgatgga    780
 cttgaaccgc aaagctgagg ccattggata cgcctaccct acccgggaca tcttcatgga    840
 aaacatcatg ttctgtggaa tgggcggctt ctccgacttc tacaagctcc ggtggctgga    900
 ggccattctc agctggcaga aacagcagga aggatgcttc ggggagcctg atgctgaaga    960
 tgaagaatca tctaaagcta ttcaatatca gcagcatttt tcgaggagag tgaagaggcg   1020
 agaaaaacaa tttccagatg gctgctcctc ccacaacaca gccacagcag tggcagccct   1080
 gggtggcttc ctatacatcc tggcagaata ccccccagca aacagagagc cacacccatc   1140
 cacaccgcca ccaccaagca gccgctgaga cggacggttc catgccagct gcctggagga   1200
 ggaacagacc cctttagtcc tcatccctta gatcctggag ggcacggatc acatcctggg   1260
 aagaaggcat ctggaggata agcaaagcca ccccgacacc caatcttgga agccctgagt   1320
 aggcagggcc agggtatggt gggggccggg agggacccag gtgtgaacgg atgaataaag   1380
 ttcaactgca actgaaaaaa aaaaaaa                                       1407



      <210> 1858
      <211> 410
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> misc_feature
      <222> (1)...(410)
      <223> n = a,t,c or g


      <400> 1858
 gcatacaggc cgggtggttn tcagggggaa gtcttgtcca caggtgttga tgacgtactt     60
 ccagggaacc tcagaggcga caaggtcttt cagacagttc aggtcagcct ggagtctgga    120
 aatgcctgca taaaccacag actctgtctt tgaagcaatg aaagcatttt ggaagcaact    180
 cagtaactgc ctcacagatt ccttatactc agctggggct ttctcatcca cgtgaacaca    240
 gtagacattt tggggcatat agatagccct aaagagcctt tcaaaggtgt caaagtcctt    300
 atggatgacc atgacatagg ccaaagggaa tgcagcctct tcttccgaca ggggacttgt    360
 gatgtagtga ttctgggtca ggtaatcctt gcaagggaca cttcgcagag               410



      <210> 1859
      <211> 587
      <212> DNA
      <213> Homo sapiens


      <400> 1859
 ggggctggaa gtggaagcgc agcggcagaa ggagagggag agagaaagag agagaggcta     60
 attaaaaaag gatactccga gggaagagag caagggcggt gcgccgccaa ggaccaacta    120
 gcggcggagc ttcgatcttg cctaggcgcg gagagctccc aacctgggct ggaaccttgc    180
 ccagcacagg tggctgctac accccatgta aaaagcggaa aataaaatga agattttcca    240
 gcgcaagatg cggtactggt tgcttccacc ttttttggca attgtttatt tctgcaccat    300
 tgtccaaggt caagtggctc cacccacaag gttaagatat aatgtaatat ctcatgacag    360
 tatacagatt tcatggaagg ctccaagagg gaaatttggt ggttacaaac ttcttgtgac    420
 tccaacttca ggtggaaaaa ctaaccagct gaatctgcag aacactgcaa ctaaagcaat    480
 tattcaaggc cttatgccag accaaaaatt cccaggttca attattggct tccattaaga    540
 taaagaaagc cagccagctc aagggccatt cagaatttaa ggtttag                  587



      <210> 1860
      <211> 1734
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> misc_feature
      <222> (1)...(1734)
      <223> n = a,t,c or g


      <400> 1860
 ggcacgagct caaggtcttt gccctgggcc tgcgagggta cctgtcctac cccagcaacg     60
 tgtttgacgg gctcctcacc gttgtcctgc tggaggccgg agatggtggg cctgctgtcg    120
 ctgtgggaca tgacccgcat gctgaacatg ctcatcgtgt tccgcttcct gcgtatcatc    180
 cccagcatga agccgatggc cgtggtggcc agtaccgtcc tgggcctggt gcagaacatg    240
 cgtgcttttg gcgggatcct ggtggtggtc tactacgtat ttgccatcat tgggatcaac    300
 ttgtttagag gcgtcattgt ggctcttcct ggaaacagca gcctggcccc tgccaatggc    360
 tcggcgccct gtgggagctt cgagcagctg gagtactggg ccaacaactt cgatgacttt    420
 ncggctgccc tggtcactct gtggaacttg atggtggtga acaactggca ggtgtttctg    480
 gatgcatatc ggcgctactc aggcccgtgg tccaagatct attttgtatt gtggtggctg    540
 gtgtcgtctg tcatctgggt caacctgttt ctggccctga ttctggagaa cttccttcac    600
 aagtgggacc cccgcagcca cctgcagccc cttgctggga ccccagaggc cacctaccag    660
 atgactgtgg agctcctgtt cagggatatt ctggaggagc ccggggagga tgagctcaca    720
 gagaggctga gccagcaccc gcacctgtgg ctgtgcaggt gacgtccggg ctgccgtccc    780
 agcaggggcg gcaggagaga gaggctggcc tacacaggtg cccgtcatgg aagaggcggc    840
 catgctgtgg ccagccaggc aggaagagac ctttcctctg acggaccact aagctgggga    900
 caggaaccaa gtcctttgcg tgtggcccaa caaccatcta cagaacagct gctggtgctt    960
 cagggaggcg ccgtgccctc cgctttcttt tatagctgct tcagtgagaa ttccctcgtc   1020
 gactccacag ggacctttca gacaaaaatg caagaagcag cggcctcccc tgtcccctgc   1080
 agcttccgtg gtgcctttgc tgccggcagc ccttggggac cacaggcctg accagggcct   1140
 gcacaggtta accgtcagac ttccggggca ttcaggtggg gatgctggtg gtttgacatg   1200
 gagagaacct tgactgtgtt ttattatttc atggcttgta tgagtgtgac tgggtgtgtt   1260
 tctttagggt tctgattgcc agttattttc atcaataagt cttgcaaaga atgggattgt   1320
 cattcttcac ttcagcacag ttctagtcct gcttctctgg agtagggttg ttgagtaagg   1380
 ttgcttgggt tgtgcattgc acaagggcac atggctgtaa ggtgtatcct ggcggggggc   1440
 tgtctacctg cagtgagggg caccttttct gttttgctca aaggcatgta taaaccaatg   1500
 ggcgacctta tttcctgtgt cttcaggcgt gtgacagggg gcctggggtg gtgaggtggg   1560
 gccagcgatc aatgtgtgga aagccttgtt gtcacctgaa gcacgccagg tacagattga   1620
 ccaatggttt tctcacttca ggggccaacc cacgccccct ttctgctgaa gtttgggtgc   1680
 catctactgg tgggatggga cttggttgac tacatttaag gtaaggcgga ccca         1734



      <210> 1861
      <211> 690
      <212> DNA
      <213> Homo sapiens


      <400> 1861
 tttttttttt ttgcattttg gttattttta gttaaagaaa aacagctttc tccaagggcg     60
 acaaagtgaa ctgaaggtca gaaggaagct gggtgcgggc ttcctgcaag ctcttgctcc    120
 aaaacctgga agtgaggaga gggcgctccg gagctctggg gaaggttggt gcacacaggg    180
 gttccgttgg tgggggagaa gagccgccag cccacacacg gtcactggat tggtgtgagt    240
 gggttccaag cgactgccat gtgctagtcc actgacatga ttgacattaa cattcttggg    300
 gggcattaaa ttaaggaatg acacagggag ccaagagagt ggcttattcg gttggattct    360
 gaatcacaat caggaaatag tctttatctg gtgcaaccat aatttcattt ttcttggagc    420
 gaattcgaag gaaggtgaga tcgttctggg ggtcgatgtc acgcacggtg ctccgtgcct    480
 tcaggatgaa gctgtgcatg aggctggcat actgggtggt ggtggggttg tccatggtgc    540
 tcttgatggg aatgccttct gtgttcacga cgatgattcc ctgcactccc ttctggctct    600
 gcagtcgctt cagtgtctcc tccacctctg ccatttccga ccgatccggt agccccgcgt    660
 agcgaacact tagcgagtcc tgctcgtgcc                                     690



      <210> 1862
      <211> 767
      <212> DNA
      <213> Homo sapiens


      <400> 1862
 gctggccaag taagccacta acctaggtca taaagagtta gctttgggac catttatttc     60
 catgatcaaa ataaatacat ctgggtttaa cctgaatcac catttagtaa catagtcatc    120
 agtttcagta cctttgtctt tttccaggta aaactcttta gcctcttatc aaacatgtta    180
 tgccacatct aaattccata ttttatgtaa tataaggaaa aatagtttta tttgtatgat    240
 ttatacttca tgtgttagga acctgtgact acatgttctg aactgttagt aagaaaaatg    300
 gtattggata ccttactctt taagattttt aattattttt ggtaaaactg ggaaatagcc    360
 gtctgatttg cattttattt tcttttgtat tttaaggata tggaatatta tcttgtaaaa    420
 tggaaaggat ggccagattc tacaaatact tgggaacctt tgcaaaatct gaagtgcccg    480
 ttactgcttc agcaattctc taatgacaag cataattatt tatctcaggt aaagaaaggc    540
 aaagcaataa ctccaaaaga caataacaaa actttgaaac ctgccattgc tgagtacatt    600
 gtgaagaagg ctaaacaaag gatagctctg cagagatggc aagatgaact caacagaaga    660
 aagaatcata aaggaatgat atttgttgaa aatactgttg atttagaagg gcccaccttc    720
 agacttctat tacattaacg aatacaaacc agctcctgga atcagct                  767



      <210> 1863
      <211> 1623
      <212> DNA
      <213> Homo sapiens


      <400> 1863
 ggcacgagcc gagtcgttgg cgctgtcatg gcgggtgtgc tgaagaagac cactggcctt     60
 gtgggattgg ctgtgtgcaa tactcctcac gagaggctaa gaatattgta cacaaagatt    120
 cttgatgttc ttgaggaaat ccctaaaaat gcagcatata gaaagtatac agaacagatt    180
 acaaatgaga agctggctat ggttaaagcg gaaccagatg ttaaaaaatt agaagaccaa    240
 cttcaaggcg gtcaattaga agaggtgatt cttcaggctg aacatgaact aaatctggca    300
 agaaaaatga gggaatggaa actatgggag ccattagtgg aagagcctcc tgccgatcag    360
 tggaaatggc caatataatt attaagtgac tttggtgtgt tcatgggaaa ctgatgtaat    420
 taaatattct gttatattaa gagcgtgttc ttattactga cattttgtaa tcaagaaaag    480
 tgatatagaa aatatgtagg agactgttaa aattggtgat tatggtaata tggtcatgtg    540
 aatcaatttt tgatttataa agtactcaca caagttgttt caaagatgat atttctgtga    600
 acagagaggc catgggaaga tttgaaaatt attaaagaaa aattcctaca gattttcaat    660
 gcagagacca taatcaaaaa gtaaactttc tttagtagta tgttcaatac atcatttaat    720
 tttttaagtt atcctgaaga aggaaaggtc cttaattatt atagtctaaa caaatttata    780
 gattactgtt tgaagtaaat aatacgagtg aatattttca aatgtgataa aatagcacaa    840
 gtggctggtg ataaaatttg aaattatggt taacctcagc tgtgatctta tgtatgtaaa    900
 gtgaaattta aatagataat tataggttga ttacaaaatc catagtgtca ttttatttta    960
 gtcattattg aattatacca tttactctgt tttcttatag tcttaatttt attatatttt   1020
 gttgttactg tattatattt gaaaaccttc aaattagaat acattgtaca gttaaagaaa   1080
 ttgacttggt acttaaaaga aagatttccc attgcataca ggttattgga gaaattttcc   1140
 ttttgttgca tttgtggaag ttagttttct ggcccgtggc ctttaatttt cttaatcaac   1200
 ctaattacat caggatagag gtagagtttc tgtaaaagaa gagacattaa gagttcctga   1260
 aatttatatc tggcatacgg ataggcttat attcaaaaca tcttagtcat acgaccataa   1320
 attaaaagtg gagtcactaa atagtttgca gtacgtttct aatataagtg taggtgggta   1380
 tcaaaacaag acaaatgctg ttcagggaaa gaagttggca agcttaaggt taaacaaaaa   1440
 taaaattaca tgtgttttcg caaaaaaaaa aaaaaggggc ggccgtttta aaggatcctt   1500
 gggggggcca aatttaacgc gggcaggcaa ggaaatattt ttttccttat ggggagccga   1560
 attataacct acctggggat ttttgaaagg gacccttact tgtgggggga gacataatgg   1620
 aaa                                                                 1623



      <210> 1864
      <211> 2658
      <212> DNA
      <213> Homo sapiens


      <400> 1864
 ggaattcgtt ttaagaggat cttctgctcc tcttcatctg gtccgtttcc ttccaaggcc     60
 cccgagagga aggcatgcgg tgggccctac tggtgcttct agctttcctg tctcctgcca    120
 gtcagaaatc ttccaacttg gaagggagaa cgaagtcagt caccaggcag actgggtcat    180
 ctgctgaaat cacttgcgat cttactgtaa caaatacctt ctacatccac tggtacctac    240
 accaggaggg gaaggcccca cagcgtcttc tgtactatga cgtctccact gcaagggatg    300
 tgttggaatc aggactcagt ccaggaaagt attatactca tacacccagg aggtggagct    360
 ggatattgag actgcaaaat ctaattgaaa atgattctgg ggtctattac tgtgccacct    420
 gggacaaccg gaaagaatta ttataagaaa ctctttggca gtggaacaac acttgttgtc    480
 acagataaac aacttgatgc agatgtttcc cccaagccca ctatttttct tccttcgatt    540
 gctgaaacaa aactccagaa ggctggaaca tacctttgtc ttcttgagaa atttttccca    600
 gatattatta agatacattg gcaagaaaag aagagcaaca cgattctggg atcccaggag    660
 gggaacacca tgaagactaa cgacacatac atgaaattta gctggttaac ggtgccagaa    720
 gagtcactgg acaaagaaca cagatgtatc gtcagacatg agaataataa aaacggaatt    780
 gatcaagaaa ttatctttcc tccaataaag acagatgtca ccacagtgga tcccaaatac    840
 aattattcaa aggatgcaaa tgatgtcatc acaatggatc ccaaagacaa ttggtcaaaa    900
 gatgcaaatg atacactact gctgcagctc acaaacacct ctgcatatta cacgtacctc    960
 ctcctgctcc tcaagagtgt ggtctatttt gccatcatca ccctgctgtc tgcttagaag   1020
 aacggctttc tgctgcaatg gagggaaatc ataacagacg gtggcacaga gaggcccatc   1080
 ttttcctcat cggttattgt ccctagaagc gtcttctgag gatctagttg gggctttctt   1140
 tctgggtttg ggccatttca gttctcatgt gtgtactatt ctatcattat tggtataatg   1200
 gttttcaaac cagtgggcac acagagaacc tcactctgta ataacaatga ggaatagcca   1260
 tggcgatctc cagcaccaat ctctccatgt tttccacagc tcctcctgcc aacccaaata   1320
 gcgcctgcta tagtgtagac agcctgcggc ttctagcctt gtccctctct tagtgttctt   1380
 taatcagata actgcctgga agcctttcat tttacacgcc ctgaagcagt cttctttgct   1440
 agttgaatta tgtggtgtgt ttttccgtaa taagcaaaat aattcaacta gcaaagaaga   1500
 ctgcttcagg gcgtgtaaaa tgaaaggctt ccaggcagtt atctgattaa agaacactaa   1560
 gagagggaca aggctagaag ccgcaggatg tctacactat agcaggcgct atttgggttg   1620
 gctggaggag ctgtggaaaa catggagaga ttggtgctgg agatcgccgt ggctattcct   1680
 cattgttatt acagagtgag gttctctgtg tgcccactgg tttgaaaacc attatacaat   1740
 aatgatagaa tagtacacac atgagaactg aaatggccca aacccagaaa gaaagcccaa   1800
 ctagatcctc agaagacgct tctagggaca ataaccgatg aggaaaagat ggcctccttg   1860
 tgccaccgtc tgttatgatt tctctccatt gcagcagaaa gccgttcttc caagcagaca   1920
 gcaggtgatg atggcaaaat agaccacact cttgaggagc aggaggaggt acatgtaata   1980
 tgcagaggtg tttgtgagct gcagcagtag tgtatcattt gcatcttttg accaattgtc   2040
 tttgggatcc attgtgatga catctgtctt tattggagga aagataattt cttgatcaac   2100
 tccgttttta ttattctcat gtctgacgat acatctgtgt tctttgtcca gtgactcttc   2160
 tggcaccgtt aaccagctaa atttcatgta tgtgtcgtta gtcttcatgg tgttcccctc   2220
 ctgggatccc agaatcgtgt tgctcttctt ttcttgccaa tgtatcttaa taacatcagg   2280
 gaaaaatttc tcaagaagac aaaggtatgt tccagccttc tggagctttg tttcagcaat   2340
 tgaaggaaga aaaatagtgg gcttggggga aacatctgca tcaagttgtt tatcaggtga   2400
 agttactatg agcttagtcc cttcagcaaa tatcttgaac caaccagtgg tatcacaccg   2460
 gtctaagctt ctacaaaaat ctcagccttc tgatcctcgg gacacgacta gcaatccaac   2520
 aactttgaac tagcaatttc atcttctggc ttttttggaa gtccttgaat ataggttttg   2580
 tgacatgtga tagtttgtaa tttttcctca taaatagcct gtaatcttct aaggcagtaa   2640
 ttcttgcgga cgcgtggg                                                 2658



      <210> 1865
      <211> 1828
      <212> DNA
      <213> Homo sapiens


      <400> 1865
 caactataag actttgatta ttatctgcgc actcttcact ttggtcacag tacttttgtg     60
 gaataagtgt tccagtgaca aagcaatcca gtttccacgg cgttcgagta gtggcttcag    120
 agtggatggg tttgaaaaaa gagcagcagc atctgagagt aacaactata tgaaccacgt    180
 ggccaaacaa cagtctgagg aagcattccc tcaggaacag cagaaagcac cccctgttgt    240
 tgggggcttc aatagcaatg tgggaagtaa ggtgttaggg ctcaaatatg aagaaattga    300
 ctgtctcata aatgatgaac acacaattaa agggagacga gaggggaacg aagtctttct    360
 tccattcact tgggttgaga aatattttga tgtttatgga aaggtggttc agtatgatgg    420
 ctatgatcgg tttgaattct ctcatagcta ttccaaagtc tatgcacaga gagcccccta    480
 tcaccccgat ggtgtgttta tgtcttttga aggctacaat gtggaagtcc gagacagagt    540
 caagtgcata agtggggttg aaggtgtgcc attatctaca caatggggac ctcaaggcta    600
 tttctatcca atccagattg cacagtatgg attaagtcat tacagcaaga atctaactga    660
 gaaacctcct cacatagagg tatatgaaac agcagaagac agagacaaaa acaagcctaa    720
 tgactggact gtgccaaagg gctgctttat ggcgaatgtg gctgataagt ctagattcac    780
 caatgtcaaa cagtttattg caccagaaac cagtgaaggt gtatccttgc aactgggaaa    840
 cacaaaagat tttattattt catttgacct caagttcttg acaaatggaa gtgtgtccgt    900
 ggttctagag accacagaaa agaatcagct cttcactata cattatgtct caaatgctca    960
 gctaattgct tttaaagaaa gagatatata ctatggcatt gggcccagaa cttcatggag   1020
 cacagttacc agggacctgg tcactgacct caggaaagga gtgggtcttt caaacacaaa   1080
 agctgtcaag ccaaccaaaa taatgcccaa gaaggtggtt aggttgattg caaaaggtaa   1140
 gggattcctc gacaacatta ccatctctac cacagcccac atggctgcat tttttgctgc   1200
 tagtgattgg ctagtaagga accaggatga gaaaggtggc tggccaatta tggtgacccg   1260
 taagttaggg gaagggttca agtctttaga gccaggatgg tattctgcca tggcccaagg   1320
 gcaagccatt tctacattag tcagggccta tctgttaaca aaagaccata tattcctcaa   1380
 ttcagcttta agggcaacag ccccttataa gtttctatct gagcagcatg gagttaaagc   1440
 tgtgtttatg aataaacatg actggtatga agaatatcca accacaccta gctcttttgt   1500
 tttaaatggc tttatgtatt ctttaattgg gctgtatgac ttaaaagaaa ctgcagggga   1560
 aaaactcgga aaagaagcaa ggtccttgta tgagcgtggc atggaatctc ttaaagccat   1620
 gctgcccttg tatgacactg gctcaggaac catctatgac ctccgtcact tcatgcttgg   1680
 catcgctcct aacctggctc gctgggacta tcataccacc cacatcaatc agttgcagct   1740
 actcagtacc attgatgagt ccccaatctt caaagaattt gtcaagaggt ggaaaagcta   1800
 ccttaaaggc agcagggcaa agcacaac                                      1828



      <210> 1866
      <211> 3570
      <212> DNA
      <213> Homo sapiens


      <400> 1866
 atgggactct cagaggatcc agaactgcag cccgtcctcg ctgggctgtc cctgtccatg     60
 tatctggtca cggtgctgag gaacctgctc agcatcctgg ctgtcagctc tgactcccac    120
 ctccacaccc ccatgtactt cttcctctcc aacctgtgct gggctgacat cggtttcacc    180
 tcggccacgg ttcccaagat aattgtggac atgcagtcgc atagcagagt catctcttat    240
 gtgggctgcc tgacacggat gtcttttttg gtcctttttg catgtataga agacatgctt    300
 ctgactgtga tggcctatga ctgctttgta gccatctgtc gccctctaca ctacccagtc    360
 atcgtgaatg ctcacctccg tgtcttctta gttttggtgt cctttttcct tagcctgttg    420
 gattcccagc tgcacaggat ccttttgtct tactgtaaaa ttgttccctc cattctaagg    480
 atttcaacat cagatgggaa atataaagcc ttctccacct gtggctctca cctggcactt    540
 gtttgcttat tttatggagc aggcattggc gtgtacctga cttcagctgt gtcaccaccc    600
 cccaggaatg gtgtggtggt gtcagtgatg tacactgtgg tcacccccat gctgaaccct    660
 ttcatctaca gcctgagaaa cagggacatt caaagcaccc tgcggaggct gctcagcaga    720
 acagtcgaat ctcatgatct gttccatcct ttttcttgtg tggggaagcg caaatccaac    780
 caagaatgtg ataccacaca tttggatgga tgtgataaac aaacaagcat tggtgaaact    840
 agagggaagg agtacaccct gtgtgacagt aggagtaacc tcacccaagg atataaggaa    900
 caaatacaga ggatgcacac gtgttgtgac attagcagta acatccattt aggatattac    960
 gaatattacc acaatgtgaa taccccctgt gatattagga gtaacatccc cctacaatat   1020
 tgggaaccat atcacacggt gtacaccccc tgtgacatta gagggaggcc catgaaccga   1080
 ggaagcaggt ggccatctgt ggcagctgtc acagcccagc ataaagctaa gcacttctac   1140
 ttattatatc attcaaaagc tgcctcagcc tgcaagggca gtaattcccc aaagcaggct   1200
 ccagggccca aggaaagccc tcggcaggga aacattgagt gtcaggcaca gggaatcagg   1260
 ccatcgggtc acctggacac cgtaaggctc caagagctgc cccctctcca ccaggaggaa   1320
 ctgacttacc aaggtgacag tctagagact gcttgcccaa ttaaagccat gatccccaat   1380
 ctcacactcc aactacggga ggacattcaa accaaaggca aagaagttga aaactttgaa   1440
 aaaaatttag aagaatgtat aactagaata accaatacgg agaagtgctt aaaggagctg   1500
 atggagctga aaaccaaggc tcgagaacta cgtaaagaat gcagtagcct caggagccga   1560
 tgccatcaac tggaagaaag ggtatcagca atggaagatg aaatgaatga aatgaagtgg   1620
 gaagggaagt ttagagaaaa aagaataaaa agaaataagc aaagcctcca agaaatatgg   1680
 gactatgtga aaagaccaaa tctacgtctc attggtgtac ctgaaagtga cggggagaat   1740
 ggaactaagt tggaaaacac tctgcaggat atcgtccaga acttccccaa tctagcaagg   1800
 cagaccaatg ttcagattca ggaaatacag agaacgccac aaagatactc ctcgagaaga   1860
 gcaactccaa gacacataat tgtcagattc accaaagttg aaatgaagga aaaaatgtta   1920
 agggcagcca gagagaaaga aatacaaact accatcagag aatactacaa acacctctac   1980
 gcaaataaac tagaaaatct agaggaaatg gataaattcc ttgacacata cactctccca   2040
 agactaaacc aggaagaagt tgaatctctg aatagaccaa taacaggctc tgaaattgtg   2100
 gcaataatca atagcttacc aaccaaaaag agtccaggac cagatggatt cacagccgaa   2160
 ttctaccaga ggtacaagga ggaactggta ccattccttc tacaactatt ccaatcaata   2220
 gaaaaagagg gaatcctccc taactcattt tatgaggcca gcatcatcct gataccaaag   2280
 gctggcagag acacaaccaa aaaagagaat tttagaccaa tatccttgat gaacgttgat   2340
 gcaaaaatcc tcaataaaat attggcaaaa cgaatccagc agcacatcaa aaagcttatc   2400
 caccatgatc aagtgggctt catccctggg atgcaaggct ggttcaatat acgcaaatca   2460
 ataaatgtaa tccagcatat aaacagagcc aaagacaaaa accacatgat tatctcaata   2520
 gatgcagaaa aggcctttga caaaattcaa caacccttca tgctaaaaac tctcaataaa   2580
 ttagaattgg aaaaaactac tttaaagttc atatggaacc aaaaaagagc ccgcatcgcc   2640
 aagtcaatcc taagccaaaa gaacaaagct ggaggcatca cactacctga cttcaaacta   2700
 tactacaagg ctacagtaac caaaacagca tgcctggccc cacaccacag tccatcaact   2760
 cctgctccag gtggaaacct cagaaaccca caaagctcgg acctgctcca ggtcaccaag   2820
 cagcagggcc aggcactggc aatccaacga gaagccccac tacatcgcat tccagctcct   2880
 gaagccattc cctggtattt tcagccccag ccggccacac agctcggatc tcctcctgtg   2940
 gatcccccca gctctgcgat gatggcagaa gagcacacag atctcgaggc ccagatcgtc   3000
 aaggatatcc actgcaagga gattgacctg gtgaaccgag accccaagaa cattaacgag   3060
 gacatagtca agaacgcctg ccttcttcag aaaaacaaac acccatttgc cccccggctc   3120
 aggctacaca acacccagag gaaccagatg cccaccagcc ctacaaacac ttgttccagg   3180
 tttgtgctca tcagggacac cctgttgcac aaagaagaaa ctgacctggt ggattttgaa   3240
 gacgtgatcg cagagcctgt gggcacctac agctttgacg gcgtgtggaa ggtgagctac   3300
 accaccttca ctgtctccaa gtactggtgc taccgtctgt tgtccacgct gctgggcgtc   3360
 ccactggccc tgctctgggg cttcctgttc gcctgcatct ccttctgcca catctgggcg   3420
 gtggtgccat gcattaagag ctacctgatc gagatccagt gcatcagcca catctactca   3480
 ctctgcatcc gcaccttctg caacccactc ttcgcggccc tgggccaggt ctgcagcagc   3540
 atcaaggtgg tgctgcggaa ggaggtctaa                                    3570



      <210> 1867
      <211> 1350
      <212> DNA
      <213> Homo sapiens


      <400> 1867
 tgttggttgg agcgagcatg tgggtctgca gtaccctgtg gcgggtgcga acccccgccc     60
 ggcagtggcg ggggctgctc ccagcttctg gctgtcacgg acctgccgcc tcctcctact    120
 ccgcatccgc cgagcctgcc cgggtccggg cgcttgtcta tgggcaccac ggggatccag    180
 ccaaggtcgt cgaactcaag aacctggagc tagctgctgt gagaggatca gatgtccgtg    240
 tgaagatgct ggcggcccct atcaatccat ctgacataaa tatgatccaa ggaaactacg    300
 gactccttcc tgaactgcct gctgttggag ggaacgaagg tgttgcacag gtggtagcgg    360
 tgggcagcaa tgtgaccggg ctgaagccag gagactgggt gattccagca aatgctggtt    420
 taggaacctg gcggaccgag gctgtgttca gcgaggaagc actgatccaa gttccgagtg    480
 acatccctct tcagagcgct gccaccctgg gtgtcaatcc ctgcacagcc tacaggatgt    540
 tgatggactt cgagcaactg cagccagggg attctgtcat ccagaatgca tccaacagcg    600
 gagtggggca agcggtcatc cagatcgccg cagccctggg cctaagaacc atcaatgtgg    660
 tccgagacag acctgatatc cagaagctga gtgacagact gaagagtctg ggggctgagc    720
 atgtcatcac agaagaggag ctaagaaggc ccgaaatgaa aaacttcttt aaggacatgc    780
 cccagccacg gcttgctctc aactgtgttg gtgggaaaag ctccacagag ctgctgcggc    840
 agttagcgcg tggaggaacc atggtaacct atggggggat ggccaagcag cccgtcgtag    900
 cctctgtgag cctgctcatt tttaaggatc tcaaacttcg aggcttttgg ttgtcccagt    960
 ggaagaagga tcacagtcca gaccagttca aggagctgat cctcacactg tgcgatctca   1020
 tccgccgagg ccagctcaca gcccctgcct gctcccaggt cccgctgcag gactaccagt   1080
 ctgccttgga agcctccatg aagcccttca tatcttcaaa gcagattctc accatgtgat   1140
 catcccaaaa gagctggagt gacatgggag gggaggcgga tctgaggggc tgggtgcagg   1200
 cccctcagtt ggggctccca ccttccccag actactgttc tcctcactgc ctcttcctat   1260
 taggaggatg gtgaagccag ccacggtttt ccccagggcc agccttaagg tatctaataa   1320
 agtctgaact ctcccttcca aaaaaaaaaa                                    1350



      <210> 1868
      <211> 418
      <212> DNA
      <213> Homo sapiens


      <400> 1868
 ataatttaga ttgtggactt agttacaggg ttatttctta ccttaaaaaa ctcagccaac     60
 agaccaaact agagtcagaa cgaatactag catcagtggg gaagaaacct ccccaggaaa    120
 ttggaattaa agtgaaaaat cattctggag gtggcatgtc cttgactcac aataaaaatt    180
 ttagaaaact attgaaagaa atcacagggg aaactgcact tagactgaca gaattgaaca    240
 ccaaagaatt tgctggcttc caaattgggc tcttaaacaa ggatttgaaa cctcagacat    300
 acagaaatgc ttatgatatt ccccgtagag gtcttttaga ccagctgacc agaatgagat    360
 ccaatctgct gaaaacgcac aagtttattg ttggacaaga tgaagattcc cttcatag      418



      <210> 1869
      <211> 394
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> misc_feature
      <222> (1)...(394)
      <223> n = a,t,c or g


      <400> 1869
 aaaggaggat cgatgcacat gtatgccaag aacttctacg ggggcaatgg catcgtggga     60
 gcgcagggcc agatattcga agcttacaac atggcagctt tgtggaaatt accttgtatt    120
 ttcatctgtg agaataatcg ctatggaatg ggaacgtctg ttgagagagc ggcancaagc    180
 acttgattac tacaagagag gcgatttcat tcctgggctg agagtggatg gaatggatat    240
 cctgtgcgtc cgagaggcaa caaggtttgc tgctgcctat tgtagatctg ggaaggggcc    300
 catcctgatg gagcttgcag acttaccgtt accacggaca cagtatgagt gaccctggag    360
 tcagttaccg tacacgagaa gaaattcagg aagt                                394



      <210> 1870
      <211> 836
      <212> DNA
      <213> Homo sapiens


      <400> 1870
 ctatgggaat ttagccttag gggctgatct gatgattctt agttctctct atctcctgag     60
 aaggagttcg ttctgttggt cttccctggc ccagggatgc tttgcatcct tggctccccc    120
 agtctactcc ccatgatgga ttccaggtgc ctgtgtcatg caagagcttg agctgcccct    180
 ctgtctgggg aaggcaagcc aggctggggt gctcctctgt aaatggcact ttatctttcc    240
 cacaggggtc agatctcaga ctattcatca atggccagcg accctggtgc agcctgtggg    300
 cagcccgctc tctctggagt gcactgtgga gggaacatca aaccccaacc tatactggta    360
 ccgacaggct gcaggcaggg gcctccagct gctcttctac tccgttggta ttggccagat    420
 cagctctgag gtgccccaga atctctcagc ctccagaccc caggaccggc agttcatcct    480
 gagttctaag aagctccttc tcagtgactc tggcttctat ctctgtgcct ggagtgcagg    540
 actagcggga gggccgggag agcagtactt cgggccgggc accaggctca cggtcacaga    600
 ggacctgaaa aacgtgttcc cacccgaggt cgctgtgttt gaggccatca gaagcagaga    660
 tctcccacac ccaaaaggcc acactggtgt gcctgcgcac aggcttctac cccgaccacg    720
 tggagctgag ctggtgggtg aatgggaagg aggtgcacag tggggtcagc acagacccgc    780
 agcccctcaa ggagcagccc gccctcaatg actccagata ctgcctgagc agccgc        836



      <210> 1871
      <211> 702
      <212> DNA
      <213> Homo sapiens


      <400> 1871
 aaagcaggtg cctggaaaag cctgctgagg gtgaagggga accatccagt gtcctgggtt     60
 ggggaagcat tttcctcttt atgagtctgt ctctggtcct catggaacaa aagtgggcag    120
 tggtggtatg agaagcagag gctaattgtc taccccctgc ctccaagtag aattactcct    180
 tgtctgtgta cctggtgagg cagttgactg caggaaccct tctacaaaaa ctcagagcaa    240
 agggtatccg gaacccagac cactcgcggg cactgagtga gtaacatctt tcctctcttc    300
 cccacctgat ctggattcaa gtcttcctgg ccctccagcc ttcataatta aacccatacc    360
 tcttttttga caacttactc cccttctcac atgaacccca accctccccc tctacccctg    420
 accagtcttc cagtctttat agttgaagtt ggaccactcc caggcaccct tgaatttcca    480
 atcatgtatc tgctttgcac ctcacagtcc ctaactccag ccctgctaga atatgggctc    540
 tccggactgg aaagaatctt aggggtcctc taatctaacc ctcacatgat gcttcaactc    600
 ctccagatca tctctaacat agccagagtg tcacgctatg tttaagcatc ttcagggatg    660
 ggaaaatccc ccacacccat gtattgcggc cgctctagag ga                       702



      <210> 1872
      <211> 248
      <212> DNA
      <213> Homo sapiens


      <400> 1872
 ggctggtttc agtttccaag aaaagtgtgt cctacatggt aagcaaggag ggaggtggaa     60
 acatctctgt cattgtcctt gggggtgcaa aagaatcact ggatgctcat cctggaaagt    120
 tcactctgtt catccgccag cggaaaggat ttgttaaaat tgctttgacc catggcgcct    180
 ctctggtccc agtggtttct tttggtgaaa atgaactgtt taaacaaact gacaaccctg    240
 aaggagcg                                                             248



      <210> 1873
      <211> 1234
      <212> DNA
      <213> Homo sapiens


      <400> 1873
 tttttttttt ttcggtggag taattccttt taatttagac atgtgttcac atactttatg     60
 cataagaaaa tagttcatta agatacattt tcatggtagg ctgtttaaaa tctagcagta    120
 atgtgacaat atttaaactg ttctaaaaat aactcgaaat actctcagaa aagagcaccc    180
 tggacgtggc tctacattcc cctggaagtt ttgtaaatgc tagaatgttc tttgtttcca    240
 ctcaaaagta gtcatctatt tactgggaat accaaagaca tattcatgta aaataaatta    300
 tatacagaat atacatagtc tatatacata aatatacttg cacacaaatg tagaattatc    360
 caccttatgt cttttaaatc tgggtcatta cagaaacgcg gtcctctcag ccacacccgc    420
 tacttgtgca gttttccctc tggccacagg gcttcctgca aaagcagacg cagcctgttg    480
 cactcgtcca cctccggggc cgcccaccgc ctcttcaggt gctggatgtc gatggagcca    540
 gacgccctgg ccagcaccag ggccaggaag ctgccaccag ccttctcagg ctcacccacc    600
 gcagccatgg ccaccagcct gttgggggag acctgctgtt tggcgacagg acccagatcg    660
 ctctggagga ggtcccagat gtagatgttg gatgtgtcgt cctgcaccag gaacacggca    720
 ggcctggttg gggaccactg caggccggtg accgcatggc tgtccgtgct gctgtcccac    780
 tgcaggagcg gaaacgcgga gctcagctgg tgcagcctga tgcttccgtc cgaacagccg    840
 gccaaaaata ttggttctcc aaatggtgaa aaatcaatga cattaacttt cactggtctt    900
 ataccatgtt gctgaggttt gaatagtttg ggagccactc tcaaatcttg tcttgtgcca    960
 tggcttatga gacccatgtc tgtgccaata ataaagtgat taggatctga aggcagaaat   1020
 ttaacattca gtgtttgtgt agtgccccaa aattcattac ctttatggga aagactgtca   1080
 cccaactgga tcagagcact atgtaccagc ttgaccctcc ctccaggcat cagacctaaa   1140
 tcacttattg aacctgcgat gtctgccttt ggtaattcaa caaccaccca tacattgaga   1200
 accccactct catccaagga agcgatgtgg aagg                               1234



      <210> 1874
      <211> 388
      <212> DNA
      <213> Homo sapiens


      <400> 1874
 acaagagaaa gacagcttaa ctcctgatct ccctcctaat atcacactgt cctggcagca     60
 gctgcatcct gttccccacc cctcccccac aactttcctg aagatcaagc tgccatctcc    120
 aggcctcagc taagcagcct ggctgagagc aaggttctct cagctctcct aggacatggg    180
 ggaggcccac tcactctgct tcctatgaca cacaggtaca actagggtcc agctgtgaag    240
 cgagatattt tggacagcaa atgggaaggg tatttatact gaatcatgta tccactcatg    300
 gtccagagat cacagctgag agtggtgctt attccttatg tctataacaa cataagcaat    360
 actataatga ccactaaaac actaggcc                                       388



      <210> 1875
      <211> 1520
      <212> DNA
      <213> Homo sapiens


      <400> 1875
 atggaggagc ttttaggaac tgtatttgtg atctggtggc tttggcctgg cagctacggc     60
 accagtgcag ctgatactca aggttcagat cagaagagga ggcttctcac cctgcagcag    120
 ggacctgtga gcatggcatg ccctggcttc ctgtgggcac ttgtgatctc cacctgtctt    180
 gaatttagca tggctcagac agtcactcag tctcaaccag agatgtctgt gcaggaggca    240
 gagaccgtga ccctgagctg cacatatgac accagtgaga gtgattatta tttattctgg    300
 tacaagcagc ctcccagcag gcagatgatt ctcgttattc gccaagaagc ttataagcaa    360
 cagaatgcaa cagagaatcg tttctctgtg aacttccaga aagcagccaa atccttcagt    420
 ctcaagatct cagactcaca gctgggggat gccgcgatgt atttctgtgc ttataggagc    480
 ggaagagatg acaagatcat ctttggaaaa gggacacgac ttcatattct ccccaatatc    540
 cagaaccctg accctgccgt gtaccagctg agagactcta aatccagtga caagtctgtc    600
 tgcctattca ccgattttga ttctcaaaca aatgtgtcac aaagtaagga ttctgatgtg    660
 tatatcacag acaaaactgt gctagacatg aggtctatgg acttcaagag caacagtgct    720
 gtggcctgga gcaacaaatc tgactttgca tgtgcaaacg ccttcaacaa cagcattatt    780
 ccagaagaca ccttcttccc cagcccagaa agttcctgtg atgtcaagct ggtcgagaaa    840
 agctttgaaa cagatacgaa cctaaacttt caaaacctgt cagtgattgg gttccgaatc    900
 ctcctcctga aagtggccgg gtttaatctg ctcatgacgc tgcggctgtg gtccagctga    960
 gatctgcaag attgtaagac agcctgtgct ccctcgctcc ttcctctgca ttgcccctct   1020
 tctccctctc caaacagagg gaactctcct acccccaagg aggtgaaagc tgctaccacc   1080
 tctgtgcccc cccggcaatg ccaccaactg gatcctaccc gaatttatga ttaagattgc   1140
 tgaagagctg ccaaacactg ctgccacccc ctctgttccc ttattgctgc ttgtcactgc   1200
 ctgacattca cggcagaggc aaggctgctg cagcctcccc tggctgtgca cattccctcc   1260
 tgctccccag agactgcctc cgccatccca cagatgatgg atcttcagtg ggttctcttg   1320
 ggctctaggt cctggagaat gttgtgaggg gtttattttt ttttaatagt gttcataaag   1380
 aaatacatag tattcttctt ctcaagacgt ggggggaaat tatctcatta tcgaggccct   1440
 gctatgctgt gtgtctgggc gtgttgtatg tcctgctgcc gatgccttca ttaaaatgat   1500
 ttggaagagc aaaaaaaaaa                                               1520



      <210> 1876
      <211> 436
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> misc_feature
      <222> (1)...(436)
      <223> n = a,t,c or g


      <400> 1876
 tttcgtggac tgaactcccg cagtttctaa tannnnccag ttgcaagagc tctggaaaag     60
 atgttggtgc taaactgttc taccaaatta ctgatactgg agaaaacgtt gaagagttgc    120
 tttcctgaat ctctcaaggt ttacggagcg gtgatgaaca taaatcgtgg gaaccccttt    180
 caaaaggaag tggtgttgga ttcatggccg gatttcatag ctgttatcac ccgacgacaa    240
 agagaggctg agacagataa ccttgatcat tatactaatg cctatgctgt gttctacaag    300
 gatgtcaggg cttatcgaca gctattggaa gaatgtgatg cttttaactg ggaccaagtt    360
 tttcaaatac aagggctgca gagtgagtta tatgatgttt ccaaagcggt tgacaattca    420
 aagcagttga atataa                                                    436



      <210> 1877
      <211> 424
      <212> DNA
      <213> Homo sapiens


      <400> 1877
 gcagtgggct tcaagatcac cgctggcaag gactgggttg gtttttggag cagtttctgc     60
 tgacgtgaca aaaagatctc tcatatgata ttccgaggta tctttgagga agtctctctt    120
 tgaggacctc cctttgagct gatggagaac tgggctcccc acaccctctc tgtccccagc    180
 tgagattatg gtggatttgg gctacggccc aggcctgggc ctcctgctgc tgacccagcc    240
 ccagaggtgt tagcaagagc cgtgtgctat ccaccctccc cgagaccacc cctccgacca    300
 ggggcctgga gctggcgcgt gactatgcgg cttgggctgt gtgtggtggc cctggttctg    360
 agctggacgc acctcaccat cagcagccgg gggatcaagg ggaaaaggca gaggcggatc    420
 agtg                                                                 424



      <210> 1878
      <211> 864
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> misc_feature
      <222> (1)...(864)
      <223> n = a,t,c or g


      <400> 1878
 ttagganggg cagggagtcg tgtggaaggg ccactgcagc ccggtgcctg gcaattagta     60
 ggtgctcagg aaatgtggtt cttgagcctc tgcccttctc tttgttgttg gttttgcaga    120
 gtcattaagg gagtttactg cagactgtcc cccatataag tgtcctgtgg cccctgagcc    180
 tttgcctcag cctctctctc tccctgcagt gccctgggga ggaatcaact gacagccctt    240
 tcagtcttcc cacagtccag ccagttaaat caaggtgttc cccttttata gaggagtctc    300
 ctagagccaa ccgcagcatc cctgcctttg ggagccacct ggaatgtgcc agctgcagta    360
 gccgttcctt ccacggcccc cccccatgct gtctgtgggg cttgccactg agtgctccat    420
 ctccccatgt gctccatccc ccggcatctg ctgccattgg tcctgcctgt tgcgttactt    480
 ctctgtgccc tggagcccct caagcacaga ggcctcgaaa ggttgatcag acatcctcag    540
 cacctggagc ggggcctggc acacaagacg gcaatgaacg gcccaacccc tagaagttca    600
 ccccccacaa gaccctgcag ggcgggggct gagtgtccca agaagcctct tgggaaggga    660
 tggtcttaga ccctagtggt gtcttcccat tctgcagagg cctagggatg tccccaggtc    720
 cccagagtgg gaggggaagg gtcagaagtc catggaaata aaacacaggg ccagctacaa    780
 aatttgtggg gcccagtgca aaatgaagat gcaagttccc ttgttcaaaa agcagtaaaa    840
 aaaaaaacac aaaagttttt tcaa                                           864



      <210> 1879
      <211> 1156
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> misc_feature
      <222> (1)...(1156)
      <223> n = a,t,c or g


      <400> 1879
 tttttttttt ttgtcgccac agcagcggac acgtttaatg gcaggcgcct ctacagttac     60
 aagacatgcc tgaggtcagt tcgccccctt agggggcact ccccgagcta aacacagatg    120
 acagcgaccc agggtgctgg aggcccgggg tcacctgagg actgcagaag tcctgcgctc    180
 cgctaactgt gtggacacgc ggctgccagg ggcacaggta ggcaacatgg atgggaagag    240
 agcccaggcc gcccccgtct cacagctgca gagcacgcag accacggcac tgcaggccaa    300
 ccaggcagag ctgctggtgc gacacatcct ggggctgggc tggtcgggga gaagctctcc    360
 ggctgacgct gcctgggcct gcccctgcag ggcccgggaa ccgagcccag gcctctgttt    420
 ctctgagagg ctggagcaga gcccttggtg gccctggaaa gcggctgcaa ggtggcctta    480
 gtcaggggag gcacgcgggc gtcgcgtcca gaatcttctg ggctatggag gtgagtgcag    540
 cgaaggcggg gctcccaggg aactcctgga tgaagtcgtg gccctcctcc agggtcctca    600
 tgagcgcagg gtccaggggc acggagccta agaagggcac cccggcgagc tgggccagct    660
 cctctccgcc gcccctggag aagacgctgg tgcactccgt gcagtgtggg caggtgaagc    720
 cgctcatatt ctccacgatt cccatcaccc gcaagcccgt cttcctacag aaggtcagct    780
 cgcgcctcac gtcccccacg gacaccgcct ggggcgtggt gaccacgagg gcccccaggg    840
 gctggtaggg acgcagggct tctatggtgg ccatgtgctc atcggaggtc cccgggggcg    900
 tgtccaccac caggtagtcc agctcccccc aggccacgtc ggacacaaac tgctttatca    960
 gcgcttcttg cctgcatggc gcagtgccag ggccagctcc gtggagatgg tgcttttccc   1020
 aacgcccccc tttcctgaga ggaccaggat gatgtgcctg acgccggcca ggtttccagg   1080
 cntgccgccg cctccatccc gccgcctcca ggagctcgng gctgcacgtc cttacccgcg   1140
 gccgtcagcc tcccag                                                   1156



      <210> 1880
      <211> 404
      <212> DNA
      <213> Homo sapiens


      <400> 1880
 tttcgtctgt gagctgcggc agctgagcag aggcggcggc gcgggacctg cagtcgccag     60
 ggattccctc caggtgacga tgctctggtt ctccggcgtc ggggctctgg ctgagcgtta    120
 ctgccgccgc tcgcctggga ttacgtgctg cgtcttgctg ctactcaatt gctcgggggt    180
 ccccatgtct ctggcttcct ccttcttgac aggttctgtt gcaaaatgtg aaaatgaagg    240
 tgaagtcctc cagattccat ttatcacaga caacccttgc ataatgtgtg tctgcttgaa    300
 caaggaagtg acatgtaaga gagagaagtg ccccgtgctg tcccgagact gtgccctggc    360
 catcaagcag aggggagcct gttgtgaaca gtgcaaaggt tgca                     404



      <210> 1881
      <211> 380
      <212> DNA
      <213> Homo sapiens


      <400> 1881
 tctcaggagg cagcgctcta ggacatttct ttcatggcct gggctctgct gctcctcacc     60
 ctcctcactc agggcacagg gtcctgggcc cagtctgccc tgactcagcc tgcctccgtg    120
 tctgggtctc ctggacagtc gatcaccatc tcctgcactg gaaccagcag tgacgttggt    180
 ggttataact atgtctcctg gtaccaacag cacccaggca aagcccccaa actcatgatt    240
 tatgaggagt caccaccagt gcacattggc cctgtatttg tatccagaac caatcaaagc    300
 cacccctgag tcctgcatct ctcagtacca agctccagtc ccccttcaag accacccacc    360
 acacagacgt gcagggagcg                                                380



      <210> 1882
      <211> 2883
      <212> DNA
      <213> Homo sapiens


      <400> 1882
 atggcatggc agctggctgc tctcagaatg acttgtcggg agagagaggg taagacacag     60
 ggtaagcgtg gcctttatga cttggctggg gagccacgag ctattgtgtg gctgtatgct    120
 atggtcatgc agaccagcac tgatgcaaca cggcccgagc aggctcctct ccatcagctg    180
 aagtccttca tctctcccat ccttcctgct acgtgttcca gggatggctc agctacatac    240
 ctgaggcctg gcaagttcac tgatggctcc tgcagaagca caaactgcat gtctcccggt    300
 gacttggact gcactgacac cagttggatt ttacccagca gaccagatgc aggtgggaga    360
 ttccccatcc gcacccctcc ctgtgtgctt gtggttcata agccaagccg acactgcagg    420
 gagtggactg ccaatactgt gttacctaag ggcgctttgg caaagtggct tcttgagccc    480
 aaagcagacc tacagggctg gcatctgcca gcagatgggc agtatacaaa accttcaatt    540
 agttacaaca tcaaacttta catcaactgt tataaccgga ctgtgactac ggcagctcag    600
 caccaacagg ttcagaggaa gcatggagcc tccatcttct tggcagaaaa tgtcgctgtg    660
 agggagaaag acaaagagga acgcaaggtg actagggctc caacagagca ggcctggact    720
 gcaggatcgt ggatagaaac agcctataga gaaataaagg gagtagggca agaaagtgtt    780
 tgcataaccg taatgcacct tgaagagtta gtgtatgaac tagcctggat cattatgtct    840
 gctgtggtag aggcttttga tccagtagca ccatccagca aatgccggct taacccagac    900
 ccagaccctt actgctgcac accttacaca ctacacacta gcccacctcc tccaccttcc    960
 tgctgcacac cctacaccct gcacactggc ccacctccac agacaccttt ctgctgcaca   1020
 ccctataccc tggacaccag cccatctcca cagacacatt cctgctgcac accctacacc   1080
 ctacacactg tccccacctt ccaccttcct gctgcccacc ctatacactt gcacaccatc   1140
 ccacctccac agacacaagg ccagggcttt gtaagtgagg atgagtacct ggagatctct   1200
 gacatcaagc gagaccagtc cggggagtac gaatgcagcg cgttgaacga tgtcgctgcg   1260
 cccgatgtgc ggaaagtaaa aatcactgta aactatcctc cctatatctc aaaagccaag   1320
 aacactggtg tttcagtcgg tcagaagggc atcctgagct gtgaagcctc tgcagtcccc   1380
 atggctgaat tccagtggtt caaggaagaa accaggttag ccactggtct ggatggaatg   1440
 aggattgaaa acaaaggccg catgtccact ctgactttct tcaatgtttc agaaaaggat   1500
 tatgggaact atacttgtgt ggccacgaac aagcttggga acaccaatgc cagcatcaca   1560
 ttgtatgttg accacatagt tggaagtaaa gctctcctca gcaaatgtaa aagaacagaa   1620
 attataacaa actatctctc agaccacagt gcaatcaaac tagaactcag gattaagaat   1680
 ctcactcaaa accactcaac tacatggaaa ctgaacaacc cgctcctgaa tgactactgg   1740
 gtacataacg aaatgaaggc agaaataaag atgttctttg aaaccaacaa gaacaaagac   1800
 acaacatacc agaatctctg ggacgcattc aaagcagtgt gtagagggaa atttatagca   1860
 ctaaatgccc acaagagaaa gcaggaaaga tccaaaattg acaccctaac atcacaatta   1920
 aaagaactag aaaagcaaga gcaaacacat tcaaaagcta acagaaggca agaaataact   1980
 aaaatcagag cagaactgaa ggaaatagag acacaaaaaa cccttcaaaa aattaatgaa   2040
 tccaggagct ggttttttga aaggatcaac aaaattgata gactgctagc aagactaata   2100
 aagaaaaaaa gagagaagaa tcaaatagac gcaataaaaa atgataaagg ggatatcacc   2160
 acctatccca cagaaataca aactaccatc agagaatact acaaacacct ctatgcaaat   2220
 aaactagaaa atctagaaga aatggataaa ttccttgaca catacactct cccaagacta   2280
 aaccaggaag aagttgaatc tcagaataga ccaataacag gatctgaaat tgtggcaata   2340
 atcaatagct taccaaccaa aaagagtcca ggaccagatg gattcacagc cgaattctac   2400
 cagagataca aggaggaact ggtaatttac agattcaatg ccgtccccat caagctacca   2460
 atgcctttct tcacagaatt ggaaaaaact actttaaagt tcatatggaa ccaaaaaaga   2520
 gcccgcatcg ccaagtcagt cctaagccaa aagaacaaag ctggaggcat cacattacct   2580
 gacttcaaac tatactacaa ggctacagta accaaaacag catggatcaa gtccctgctg   2640
 acctgggcca tcatctgcta taatctccaa catacccatg ggccaaccca cttttcttca   2700
 tttatctgtt cccacagtca ttcaacaagc atttattggg agcaaattgc tgatgaggcc   2760
 ctggactaca gtaacgaaac accagtggca cataggtcag accatgctgg tttgagcaga   2820
 agcgacaaga acgagaaccc tgttggaatt ttcgagggtg gctccaggac agccagctgg   2880
 tga                                                                 2883



      <210> 1883
      <211> 1803
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> misc_feature
      <222> (1)...(1803)
      <223> n = a,t,c or g


      <400> 1883
 tttttttttt ttgccacagg ttggacaggt ttttattgga gagtcaggag ttgctttcct     60
 tccctcgtcc ctgcctcccc cactcaaaga accccactcc agtggggctt gtccttcatc    120
 tgcccctagg aatccccatc cccagctaca caggcactca gggagagcgc acatgctgtg    180
 tgggcagaca gccccaggcc aggtaggcag tgagctccct caaatcctcc cacccccagg    240
 actcaggagg gaggggcagg agaggtgtgg gcccggtgtg cagtcctcag gcggccccct    300
 gagctcgcag ccagccaggc cttgtgcctc caggatggat ggtgtgatga ggcacatgcc    360
 ccgtagcctt tcccttccgg agggccttaa ccaagaagta tcttgtttag gggctgggga    420
 cagggtgggg aagatgacag gaggacagct gacctcttca ccctttgagt ggtatcccct    480
 tcagaagatt ccagccaaca ccagaggagg caggagcagt agtcccagga gagggcccca    540
 cacatgacca gggcccgagt tcagccctga cacgacgcta ggcttgtcag ggccctctgc    600
 acccattttc ctagagtctg atgcttcagt cgcccggaag gatggggcct cagttaccag    660
 gtaaggcaaa tcctgagcat cttccgggct tccgatgggt tcacagaggg agttcttgca    720
 gtggtagcca gagggacatt gggagcacgg agtcccctcc tggtagggcc gtttcccctt    780
 cacgttcccc ggaggctcat agttgcacac cagtaattcg atgttggtct cctcaacacc    840
 ctggagcttc tcacagaagt gggaaccaca gccgatcctc tctgtcttgg cccataccac    900
 ctgcgtgtag tggccgcaca tctggcctgg gctgcaggtg gcggcgctga ggttgtagtg    960
 ctcacgctcg tggtgccact cctccatggc cagcggcacg tccatgccct cgtctgtgat   1020
 ggcgaacaga ttctcgccgc ggcgcccgcg ctccttgttg tggccccaca cgcactgccg   1080
 tgcgtaggcc ttggcgaagg cggccagctc ctcgtcccat ctcatgtgca gcatgtctga   1140
 ggccgtcggg gatacctggg cccggtagag gttgtgcagc tccaccatca aacgtttctc   1200
 ctcatctgtg agggctccaa cggggcctgt ggtggccacc agcagtagca gtagcggcag   1260
 cagaagcatc aggaaactgc aggagccgtg catggtggcc agccgtctct ccttctcccg   1320
 tccaggggtc tggcagctgg atttaaagtc cttcccacac aagcaccacc ctggctgggg   1380
 tggggtagtg ggggccgtgt ttgaggccca gcccgactca cacaatgtct cagggagggc   1440
 tgggcgcttt gggtcccgac cagcatcaag tgcactcccc ttggagtcct tggcaaaaac   1500
 ctcctttctc ttggtaacgg gggctcaggc caaaagctgt gtgagttcct aagttgtgga   1560
 cagatccatt agggaaatac agtgaaatac cacttcacac tcattaggat ggctggcctg   1620
 ggaagtgctg gactcaggaa tgcaaggaca cagttctcag atgccccccg ggtggaacca   1680
 ggcactggca ctacagaatg ccctggtgtg gtcatctctg tggcctctgc caccagtcct   1740
 gcccctncnn nggnnnnttc nagtatcnat taganaccct ggagnnngaa gcctggcaac   1800
 tct                                                                 1803



      <210> 1884
      <211> 530
      <212> DNA
      <213> Homo sapiens


      <400> 1884
 attctctggt cattgagcat atccaagtga acaaagcacc taagatgcgc cgccggacct     60
 acagagctca tggtcggatt aacccataca tgagctctcc ctgccacatt gagatgatcc    120
 ttacggaaaa ggaacagatt gttcctaaac cagaagagga ggttgcccag aagaaaaagt    180
 tgaggagctc aagctttggg aaaaatgcgt gcattccttg tatcgtcatt ccagttctgc    240
 tctggatcta caaaaaattc ctggagccat atatataccc tctggtttcc cccttcgtta    300
 gtcgtatatg gcctaagaaa gcaatacaag aatccaatga tacaaacaaa ggcaaagtaa    360
 actttaaggg tgcagacatg aatggattac caatcaaagg accaacagaa atctgtgata    420
 aaaagaaaga ctaaagaaat tttcctaaag gaccccatca tttaaaaaat ggacctgata    480
 atatgaagca tcttccttgg aattgtctct gacctttcta tctgagaccg               530



      <210> 1885
      <211> 2700
      <212> DNA
      <213> Homo sapiens


      <400> 1885
 atgcttggta agagcttgga tctgttggat gacagtttgg ctgaaacagg aagcaaggag     60
 agcatccctc aaactgaggt aatagcaata agaggcagaa gacaaacttt tcagggactt    120
 aagagctgtg ataaagagtt tggggtttat gctgagtgtg atagggaacc agcaaatgtt    180
 tttcatcggg caagtggcaa ggagggaaag actggcggaa agagaaatac acaaacctca    240
 gaagggagca gacaattcac acatttctac agtttaacct tcagtgccag taagtgtcag    300
 gtagtagagc ttcagagaga aacagaagtg gctggttatg aaaaccggca gcacagcttt    360
 ttccctccct gtggtgtctt cccagataag aaagcaggcc tgaatcccgg gtgctgttct    420
 tccagaccac atgaaaggtt ggactggcta atagaaagac caaaaggtgg caggagagca    480
 gagttgagca ttcgttccct ggctctcccc ctgcctcagc actgtggctc tgacaatgac    540
 tggatccctc tacaacttcg actcttatct agagcctcct tccacagtgg acctaagcta    600
 acagagcatt tccagttgcc atggcagaag gaaaatgggg caaaggcaaa taattcaata    660
 gctctcacag cttttactgg agaaagtgat gaaatgccct cttactccac agcagggagc    720
 tcatgccaaa atatttgctg gatggcacta atgaccacca ccacaacaga ctgcgtagga    780
 gaaaacactg agaaattgaa atgggagaat tccctgacac cccttgctga acctctggag    840
 gctaacaagt ccaagatcaa ggcaccagaa aatctggtat ctgtcctgag aaggagtacg    900
 cttcagccat attttaatga acaagtgcta aatttctttg ctcagataat ttcttcaagc    960
 tgtgtcattt ggaaggaaaa taaaacagca tgggacacag caaaaagtgg aaatcgaccc   1020
 tcaggcttcc cagatagtat caaggaaact gaaactcacc agatcggtag cctgctatgg   1080
 tctgaatgtt tgtgtaaacc ccagattcat acatcgaatc ctaatcctca atgtggtggt   1140
 attggaagag agagaaagga aatgtccttg ggttccaaat gtggaaagtt gtgcagagac   1200
 tctcaaggag aaagaagttt tccgctttcc aaagctgcat ttgtcactcg ctgttgtatc   1260
 gtaactgaaa gtaatgaact ttccgatgct actgtccaga aggaactggc agggtgggat   1320
 cgggcactca tccagttgca ggtgcgagca ctattgagta gcacagggtc tcaagctgtg   1380
 gccatggact tgggcaacag gaaattagaa atatcctctg gaaagctggc cagatttgca   1440
 aatggctctg ctgtaataca gtcaggtgac actgcggtaa tggccacagc cgtcagtaaa   1500
 acaaaacctt ccccttccca gtttatgcct ttggtggttg actacagaca aaaggctgct   1560
 gcagtaggaa tgactgatgg agaatgtgtt gttaacccaa caagaaaaga aatgtcttct   1620
 agtactttaa atgtagtggt tgctggagca cctaaaagtc agactgtcat gttggaagcc   1680
 tctgcagaga acattttaca gcaggacttt tgccacgcta tcaaagtggg agtgaaatat   1740
 acccagcaaa taattcaggg catccagcag ctggtaaaag aaattggtgt taccaagagg   1800
 acacctcaga agttatttac cccttcacaa gagattgtga aacatgctca taaactcact   1860
 atggagagac tctatgcagt ttttacagat tatgaacatg ataaaatttc cagagatgaa   1920
 gctgttaaca aaataagatt agatacagag gaacaactaa aagaaatatt tccagaggtc   1980
 gatctatatg agataataga atccttcaat actgttgcaa aggaagtttt tagaagtatt   2040
 attttgaatg aatacaaaag atgcgatggt cgggatttga ctttacttcg gaatataagt   2100
 tgtgaggtag atatgtttaa aacccttcat ggatcagaat tatttcaaag aggacaaaca   2160
 cagctgcttt gtgctgttac atttgattca ttagaatcca gtattaagtt ggatcgagtt   2220
 ataacaacta taaatgggat aaaagataaa aatttcatgc tgcactatga gtttcctcct   2280
 tatgcaacta atgaaattgt caaagtcacc ggtataaata gaagagaact tgggcctggt   2340
 gctcttgctg agaaagcttt gtatcctgtt attcccaaag attttccttt tgccataaga   2400
 gttacatctg aagtcctaga gtcaaatggg tcatcttcta tggcatctgc atgtggtgta   2460
 gcaatgggat tggccaccaa aaccgatctt gagaagggtg aaatagaaga ttatcatttg   2520
 ctaacagata ttctgggaat tgaagcttac aatggtgaca tggacttcaa aatagctggc   2580
 actaataaag gaataactgc attacaggca gatattaaat tacctggaat aacaatgaaa   2640
 attgtaatgg aggctattca acaagcttca gtggcaaaaa ggagatttta cagatcatga   2700



      <210> 1886
      <211> 352
      <212> DNA
      <213> Homo sapiens


      <400> 1886
 cacacgggcg agaagcccta cgagtgcggc cagtgcggcc gcgccttcag ccacagctcg     60
 cacttcacgc agcacctgcg catccacaac ggcgagaagc cctacaagtg cggcgagtgc    120
 ggccaggcct tcagccagag ctccaacctg gtgcgccacc agcggctgca cacgggtgag    180
 aagccctacg cctgcagcca gtgcggcaag gccttcatct ggagctccgt gctcatcgag    240
 caccagcgca tccacactgg cgagaagccc tacgagtgct ccgactgcgg caaagccttc    300
 cgcggccgct cgcacttctt ccggcacctg cggacccaca cgggcgagaa gc            352



      <210> 1887
      <211> 394
      <212> DNA
      <213> Homo sapiens


      <400> 1887
 cttcatttac cattcggact atattctcca tcagcgaatt cacaccgggg agaagcccca     60
 caggtgctgt gactgcggga aggcgttcag caacagctca tatttcattc agcaccacat    120
 catccaaaca ggcgagaagc cctatgcctg ccgtgcatgt ggcaagacct tcactcagag    180
 ctcttcgctt acctagcatc agaggattca caccggagag aagccctaca aatgcaagga    240
 ctgcgggaag gccttcacac agagctcatc cctcatcaaa caccagcggt gccacaccgg    300
 ggagaagccc tataaatgcg gccagtgtgg gaagttcttc tcgcaggtct cccacctcac    360
 ccgccaccag aaaatccaca cgggggctcg tgcc                                394



      <210> 1888
      <211> 580
      <212> DNA
      <213> Homo sapiens


      <400> 1888
 ccctctagcc tcaacctgaa ggttattgcc atggatctgg cccagatgca cgcctgtcaa     60
 ggacctggaa atgaccttta cattgaagca tctgctgctc tgtgtgcagg ctctgatttc    120
 agtgtgtcag gaggactgca gtgggtccag cttgtagctc atggaagtgc tggtgatgat    180
 aatggctggc tcaggtgcca caggcctcca tggcaaggtt taggagacaa tgaactcgat    240
 ggttgcagtg gagaagtcaa tgtcagccag gatttctgtg ggaaatacac agatgtggtc    300
 aaccacatca cacaacgact ggactatgta ctctgcagaa cttatgcagc tcaacgtact    360
 tgtcactcag gctctgttgt aaaagaagtg aagttcatcc acgaccagac ctccccaaac    420
 cccaagtaca gaggattctt ccacggggtt agggagattg tgcgggaaca agggctgaag    480
 gggaccttcc acggcctcac agccactgtc cctgaaacag ggcttcgaac ccaggccatc    540
 ccttttttcg tcatgaactc cctgcgcaac tggttccgag                          580



      <210> 1889
      <211> 1451
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> misc_feature
      <222> (1)...(1451)
      <223> n = a,t,c or g


      <400> 1889
 gattctcctg cctcagcctc ctgagtagct gggactacag gtgcgcacca ccgtgcggat     60
 ttttgtattt ttagtagaga gggagttttg ccacattggc caggctggtc ttgaactcct    120
 gacctcaggt aatccaccca cctcagcctc ccaaagcact gggattacag gcgtgagcta    180
 ttgtgcccag ctgggatctt gacaaaaaca ctatttctct cctttcacct gtgctgtgta    240
 tttttccctc gcctagttcc cagacctcac tgctatatgt cttctccctg gcaggcagga    300
 tgacgcaaaa cacggtgatt gtgaatggag ttgctatggc ctctaggcca tcccagccca    360
 cccacgtcaa cgtccacatc caccaggagt cagctttgac acaactgctg aaagctggag    420
 gttctctgaa gaagtttctt tttcaccctg gggacactgt gccttccaca gccaggattg    480
 gttatgagca gctggctcta ggggtgactc agatattgct gggggttgtg agttgtgttc    540
 ttggagtgtg tctcagcttg gggccctgga ctgtgctgag tgcctcaggc tgtgccttct    600
 gggcggggtc tgtggtgatc gcagcaggag ctggggccat tgtccatgag aagcacccgg    660
 gcaaacttgc tggctatata tccagcctgc tcaccctggc aggctttgct acagctatgg    720
 ctgctgttgt cctctgcgtg aatagcttca tctggcaaac tgaacccttt ttatacatcg    780
 acactgtgtg tgatcgctca gaccctgtct tccctaccac tgggtacaga tggatgcggc    840
 gaagtcaaga gaaccaatgg cagaaggagg agtgtagagc ttacatgcag atgctgagga    900
 agttgttcac agcaatccgt gccctgttcc tggctgtctg tgtcttgaag gtcattgtgt    960
 ccttggtttc cttgggagta ggtcttcgaa acttgtgtgg ccagagctcc cagcccctga   1020
 atgaggaagg atcagagaag aggctactgg gggagaattc agtgccccct tcgccctcta   1080
 gggagcagac ctccactgcc attgtcctgt gagctgccaa agaccccacg gggtgcccgc   1140
 atgtccctgt ctagggcagc ccagggcccc cactcctggc tcctcacact tgcctcccct   1200
 atggccgctc tccagaccct cctcctttct tctccccaca tccgcacctg ctgttcccac   1260
 tctggggttc tcaagtccat gaacagatat tgttgcattt tccacaatgc tgattaaaca   1320
 taataaacaa tccagaaaag cagttttgcc cagaaagata tggttttcct tttgtttatt   1380
 acaccttgtg gcggccatgg aaagggcttt tntttgtgtt cggtatgtat ggaggttaaa   1440
 nggggagctg a                                                        1451



      <210> 1890
      <211> 5616
      <212> DNA
      <213> Homo sapiens


      <400> 1890
 gcccccgccc ggcccgcccc gctctcctag tcccttgcaa cctggcgctg catccgggcc     60
 actgtcccag gtcccaggtc ccggcccgga gctatggagc ggcgctggcc cctggggcta    120
 gggctggtgc tgctgctctg cgccccgctg cccccggggg cgcgcgccaa ggaagttact    180
 ctgatggaca caagcaaggc acagggagag ctgggctggc tgctggatcc cccaaaagat    240
 gggtggagtg aacagcaaca gatactgaat gggacacccc tctacatgta ccaggactgc    300
 ccaatgcaag gacgcagaga cactgaccac tggcttcgct ccaattggat ctaccgcggg    360
 gaggaggctt cccgcgtcca cgtggagctg cagttcaccg tgcgggactg caagagtttc    420
 cctgggggag ccgggcctct gggctgcaag gagaccttca accttctgta catggagagt    480
 gaccaggatg tgggcattca gctccgacgg cccttgttcc agaaggtaac cacggtggct    540
 gcagacccag agcttcacca ttcgagacct tgcgtctggc tccgtgaagc tgaatgtgga    600
 gcgctgctct ctgggccgcc tgacccgccg tggcctctac ttcgcttttc cacaacccgg    660
 gtgcctgtgt ggccctggtg tctgtccggg tcttctacca gcgctgtcct gagaccctga    720
 atggcttggc ccaattccca gacactctgc ctggccccgc tgggttggtg gaagtggcgg    780
 tgacctgctt gccccacgcg cgggccagcc ccaggccctc aggtgcaccc cgcatgcact    840
 gcagccctga tggcgagtgg ctggtgcctg taggacggtg ccactgtgag cctggctatg    900
 aggaaggtgg cagtggcgaa gcatgtgttg cctgccctag cggctcctac cggatggaca    960
 tggacacacc ccattgtctc acgtgccccc agcagagcac tgctgagtct gagggggcca   1020
 ccatctgtac ctgtgagagc ggccattaca gagctcccgg ggagggcccc caggtggcat   1080
 gcacaggtcc cccctcggcc ccccgaaacc tgagcttctc tgcctcaggg actcagctct   1140
 ccctgcgttg ggaaccccca gcagatacgg ggggacgcca ggatgtcaga tacagtgtga   1200
 ggtgttccca gtgtcagggc acagcacagg acggggggcc ctgccagccc tgtggggtgg   1260
 gcgtgcactt ctcgccgggg gcccgggcgc tcaccacacc tgcagtgcat gtcaatggcc   1320
 ttgaacctta tgccaactac acctttaatg tggaagccca aaatggagtg tcagggctgg   1380
 gcagctctgg ccatgccagc acctcagtca gcatcagcat ggggcatgca gagtcactgt   1440
 caggcctgtc tctgagactg gtgaagaaag aaccgaggca actagagctg acctgggcgg   1500
 ggtcccggcc ccgaagccct ggggcgaacc tgacctatga gctgcacgtg ctgaaccagg   1560
 atgaagaacg gtaccagatg gttctagaac ccagggtctt gctgacagag ctgcagcctg   1620
 acaccacata catcgtcaga gtccgaatgc tgaccccact gggtcctggc cctttctccc   1680
 ctgatcatga gtttcggacc agcccaccag tgtccagggg cctgactgga ggagagattg   1740
 tagccgtcat ctttgggctg ctgcttggtg cagccttgct gcttgggatt ctcgttttcc   1800
 ggtccaggag agcccagcgg cagaggcagc agaggcagcg tgaccgcgcc accgatgtgg   1860
 atcgagagga caagctgtgg ctgaagcctt atgtggtacc tccaggcata cgaggaccct   1920
 gcacagggag ccttggactt tacccggagg ctggtctaat tttccttccc gggagcttga   1980
 tccagcgtgg ctgatggtgg acactgtcat aggagaagga gagtttgggg aagtgtatcg   2040
 agggaccctc aggctcccca gccaggactg caagactgtg gccattaaga ccttaaaaga   2100
 cacatcccca ggtggccagt ggtggaactt ccttcgagag gcaactatca tgggccagtt   2160
 tagccacccg catattctgc atctggaagg cgtcgtcaca aagcgaaagc cgatcatgat   2220
 catcacagaa tttatggaga atggagccct ggatgccttc ctgagggagc gggaggacca   2280
 gctggtccct gggcagctag tggccatgct gcagggcata gcatctggca tgaactacct   2340
 cagtaatcac aattatgtcc accgggacct ggctgccaga aacatcttgg tgaatcaaaa   2400
 cctgtgctgc aaggtgtctg actttggcct gactcgcctc ctggatgact ttgatggcac   2460
 atacgaaacc cagggaggaa agatccctat ccgttggaca gcccctgaag ccattgccca   2520
 tcggatcttc accacagcca gcgatgtgtg gagctttggg attgtgatgt gggaggtgct   2580
 gagctttggg gacaagcctt atggggagat gagcaatcag gaggttatga agagcattga   2640
 ggatgggtac cggttgcccc ctcctgtgga ctgccctgcc cctctgtatg agctcatgaa   2700
 gaactgctgg gcatatgacc gtgcccgccg gccacacttc cagaagcttc aggcacatct   2760
 ggagcaactg cttgccaacc cccactccct gcggaccatt gccaactttg accccagggt   2820
 gactcttcgc ctgcccagcc tgagtggctc agatgggatc ccgtatcgaa ccgtctctga   2880
 gtggctcgag tccatacgca tgaaacgcta catcctgcac ttccactcgg ctgggctgga   2940
 caccatggag tgtgtgctgg agctgaccgc tgaggacctg acgcagatgg gaatcacact   3000
 gcccgggcac cagaagcgca ttctttgcag tattcaggga ttcaaggact gatccctcct   3060
 ctcaccccat acccaatcag ggtgcaagga gcaaggacgg ggccaaggtc gctcatggtc   3120
 actccctgcg ccccttccca caacctgcca gactaggcta tcggtgctgc ttctgcccac   3180
 tttcaggaga accctgctct gcaccccaga aaacctcttt gttttaaaag ggaggtgggg   3240
 gtagaagtaa aaggatgatc atgggaggga gctgaggggt taatatatat acatacatac   3300
 acatatatat atttttgtaa ataaacagga actgattttc tgcctccatc ccacccatga   3360
 gggctgcagg cactacaaaa gagctgacta ctgagaattc tggaaaacaa ggtttttttt   3420
 tatttgtagc tatagctaca acttggcagc atgggggagg gtgggaatgt cctggagggt   3480
 ctcccagccc tccgcaagca gagtacaaag gctgctcggg gggccagccg agggcgcggg   3540
 tgcagcagtg aaagcagcag cactaaacct ggtgcccccc tcaggtgggg tgtctggaag   3600
 acggtgggca atccctgcag gatgggcgag gaccagaccc cagggcgggg atcctgcatc   3660
 cctagaccat gttgggtcct gggtcagggc acctgggatg ctagggaggg gttggaaatg   3720
 ggaggggcta gacatcaaaa caataactga ggtgggggca ggtggtctca gtgtgggtgg   3780
 tccacaatgg ggcatggact gcggtctgaa gagggcctgt cctcactcag gtctgggctc   3840
 tagcagtgtg gcacttccga cagagcacgt gaccgtccag ggggaagcag ccattgtcat   3900
 ctgcctcaat cgacaggggc ttcccgcagt cctcacactt gtaacacttc atgtggaagt   3960
 tcttgtccag ggcgaccact cgcacagtct catctcggcc aggctcaggc atgatgggct   4020
 cagagcagac ggagcacctc ggggcgtact gcttgtggta gtcggggaca cagtggggcc   4080
 ggttggcctg gtccacgatg aaggaggtgc cctccagggg gcgggcgcag accacacagg   4140
 tgaagcagtg cgggtgatag gccttgcccg tggccctcag catgcggtca gtgatgggct   4200
 ccccgcaggt gttacacttc tccagggtgt cagtgtaaca gccctcgcag tacggcgccc   4260
 cctccagact gtagaactgc tggccctgga gctgctgcgc acactggtgg caggtgaagc   4320
 aggcgatgtg gaacagctgc cctagagcgc ggacggctgg ctgcgcccgg gccaggggtt   4380
 gatggcatcg gccgcagagt tcgttgacag ccacattctg cctctgagga tgctccatgt   4440
 cctgcattag ctgctgggtc agctgctcca gctcctccac ctccttcaga gtcaggggcc   4500
 ctggggcccc aggggagcgc acctggtttt ggttctgagc cggtgggggc acggggtgct   4560
 gcttctcctg cactcggggc ttctccctct gctgggcata ggtgaagctg ggaggttgag   4620
 gggagcctgt gccagcagaa agagcttcgg ggtgccccaa tttttgattt ggttgtgacc   4680
 cagatccacc tggggctcca ggactgaact tggaagccac aggagtaaac ttaggagtca   4740
 ctggagaaaa cttaggggct ggagccggag atgaggctgg gggccctcgg ggctgggtgt   4800
 tagccaaaga cacaggctgg gtctgggact ggacatggag ttggacctga ggcttgggct   4860
 ggggctgggg ctgaacatgg aactgtgtct ggctctgagc cggagccgga acctggggca   4920
 gaggctggga gctggaaggg gacttccaag gaggcagggg tgctgtgccc ccggctgcag   4980
 gcttggtact ggacttggaa ctgaatggag tggccactgg tgggggcaca tatccagatg   5040
 acacccgggc tttgaaagga tcattcttgg tcatgtcatc cagcagtgag gacagagagt   5100
 cgatctccaa atcaatactg ctcaccttct ccctgggctg tggtgggggc ggtatggggg   5160
 cctcaggccc tccctcctcc tccggaggag gcggcgggga agggaagatc tcctcctcca   5220
 gaggcgcagg gagaaatgat tcctcgatcg ggggaggggg cggcgggaag gcacctccca   5280
 gagcaccctc tgcatcgtcg ccatccccag caaggggagg tggaggcagg ggaaagtctt   5340
 ccgggggcgg cgggggaatc tcgcccaccc ggcccatctg tgcgcgctgg gccccgggtg   5400
 ccgggggagg ctcgctgtcc ccgggccgga agggattcac tttgggcttt ggggccacca   5460
 cagggccgaa cttcttctgc ggggcgtaaa aagccggagc cgagaccgaa acggagatcg   5520
 cgggagacgg gcggggggcc gccatggccg ggccgggctg cgcaggccgg agcgtgcgcg   5580
 ccgcgtctcg ggtggccgcc tcggcgccgg gtccgc                             5616



      <210> 1891
      <211> 1155
      <212> DNA
      <213> Homo sapiens


      <400> 1891
 cgcgtggcgg gcaggcggca ggaggcgggt gggtcaaggt aactctgggc tacagagtcc     60
 ttgctggggg ttcggggagc gcttggaccc cggcttctgg gacgcgtcag gagaagggag    120
 cactggcttt gctttcatca ggccaaagat gcctttcttt gggaatacgt tcagtccgaa    180
 gaagacacct cctcggaagt cggcatctct ctccaacctg cattctttgg atcgatcaac    240
 ccgggaggtg gagctgggct tggaatacgg atccccgact atgaacctgg cagggcaaag    300
 cctgaagttt gaaaatggcc agtggatagc agagacaggg gttagtggcg gtgtggaccg    360
 gagggaggtt cagcgccttc gcaggcggaa ccagcagttg gaggaagaga acaatctctt    420
 gcggctgaaa gtggacatct tattagacat gctttcagag tccactgctg aatcccactt    480
 aatggagaag gaactggatg aactgaggat cagccggaag agaaaatgaa gaccccagag    540
 acatttattg gggagtagga tgtggctgag tgcttttttt ttggccagac tagcggattc    600
 agtcctggaa gagagtatca tataatgaga cccacaggca ctggcaccct tgggttggca    660
 atagaaggtg acatggaatg gagaaaacca agattccaga tggggatagt aactagaagg    720
 tgcttcagat gcactgcctg cgggtgccag tctgaaaacc agaccgcaca gaggcctggg    780
 gctgctgatg agcttttcgg tgctctccac acacaagctc gcaaacacac atgtcccaga    840
 atagctctgt tgggttgtgt tgggagaagc ggctggagtt cattctctca cccccttatg    900
 ttggtgtttg gcgtgtgaca gcagttctac agagctctgt gttggggtca tggatgagcg    960
 gctctcttgg ctcttaaagg caggcctctc tcttcttgcc tttaaagaat cctccttcct   1020
 cacacctggc ctcctctggc ttcagcttct cagcagcaag caccagcctt ccacaacaac   1080
 actatatttt tatgctactt tcctgtttgc actactactt ttttattaaa cgatgttaaa   1140
 taatcaaaaa aaaaa                                                    1155



      <210> 1892
      <211> 657
      <212> DNA
      <213> Homo sapiens


      <400> 1892
 gggccgctgg tggtggacac cgggggacat cgtgggtatg tgccggctgg gaaactgcag     60
 ctgtaccatg tggtccccag tgcagaggag ctcagaaggc aggcggggct gaacaaagac    120
 ccccgatgtc taacaccgga gcccagccca gctctagtgc cctctattcc caccgggaac    180
 caggtcatag ccgcgtaccc ttttgtggcc agaagcagcc atgaagtgag cctgcaggca    240
 ggccagcctg tgaccatcct ggaggcccag gacaagaagg ggaaccctga gtggagcctg    300
 gtggaagtga atggacagag gggttatgtg ccttctggct tcttggccag gggctcggag    360
 cccagttctg tggggctgga gtctgccctc ttagggtacc ctctttggag cctacattgc    420
 caaatgatgg gggaggctta gaggctctga ccctgggggg aaaagaagca aaggaaaggt    480
 ggaggtggaa gggaagaccc aggcccaggg tgggtgaaag caacactcag gaggcagcca    540
 gaagacatgg gcgggcctcg cagaagtgct tggtgtggtg ggggcacagg aggctccagc    600
 caggactgct cattatgtct gcataaagaa ctcattccga cctggggtca caatgca       657



      <210> 1893
      <211> 1004
      <212> DNA
      <213> Homo sapiens


      <400> 1893
 gcacgagaag gaagtgcttt tgaatgaggt actgagggcc aaggtgttgg aagttcctaa     60
 ttctttcctc ggttaactgt gaaactctgc gtattgggaa ggcctggcct cagtcatcag    120
 gccaggagag gtactggacg ccgcgcacgc actcgtctgc cagcgaggcc caaaggggaa    180
 gcctagcgga gctcaatgtg gcagctgctg gcctctgggc cgactgtgat caaccactct    240
 atgattgtcc tatgtgtggg ctcatatgta caaattacca tattcttcag gaacatgttg    300
 acttgcattt ggaagaaaac agctttcagc aaggcatgga tagagtccag tgttctggtg    360
 atctacaatt ggctcaccag cttcagcaag aagaagacag aaagaggaga tctgaagaat    420
 caagacaaga aatagaagaa tttcagaagc tgcagagaca atatggttta gataattctg    480
 gaggatacaa acaacaacaa ctacgaaata tggagataga agtaaatagg ggaagaatgc    540
 ctccatctga atttcatagg agaaaagctg atatgatgga atcattagct cttggttttg    600
 acgatggaaa aacaaaaact tccggaatta ttgaagcact tcataggtat tatcagaatg    660
 ctgccacaga tgtgagacgg gtgtggcttt cttcagtggt ggatcacttt cattcatctt    720
 taggcgacaa aggttggggt tgtggttaca gaaatttcca aatgctactt tcatcattat    780
 tacaaaatga tgcttacaac gattgcttaa aaggtatgtt gattccttgc attccaaaaa    840
 ttcaatctat gattgaagat gcatggaagg aaggttttga tcctcagggg gcctctcaac    900
 ttattatcag gttacaggga acaaaggcct ggattggagc atgtgaagta tatatactcc    960
 tgacctctct aagggtttag tgtcatattt gttgattttc actg                    1004



      <210> 1894
      <211> 440
      <212> DNA
      <213> Homo sapiens


      <400> 1894
 cggacgcgtg gggccgccaa ggtgctcggt ccttccgagg aagctaaggc tgcgttgggg     60
 tgaggccctc acttcatccg gcgactagca ccgcgtccgg cagcgccagc cctacactcg    120
 cccgcgccat ggcctctgtc tccgagctcg cctgcatcta ctcggccctc attctgcacg    180
 acgatgaggt gacagtcacg gccctggcca acgtcaacat tgggagcctc atctgcaatg    240
 taggggccgg tggacctgct ccagcagctg gtgctgcacc agcaggaggg cctgccccct    300
 ccactgctgc tgctccagct gaggagaaga aagtggaagc aaagaaagaa gaatccgagg    360
 agtctgatga tgacatgggc tttggtcttt ttgactaaac ctcttttata acatggttca    420
 ataaaagctg aactttagag                                                440



      <210> 1895
      <211> 1899
      <212> DNA
      <213> Homo sapiens


      <400> 1895
 ccggtttgac cgcctcgacc cacgcgtccg cggacgcgtg ggcagcgatg gcggctgcgt     60
 cggggtcggt tctgcagcgc tgtatcgtgt cgccggcagg gaggcatagc gcctctctga    120
 tcttcctgca tggctcaggt gattctggac aaggattaag aatgtggatc aagcaggttt    180
 taaatcaaga tttaacattc caacacataa aaattattta tccaacagct cctcccagat    240
 catatactcc tatgaaagga ggaatctcca atgtatggtt tgacagattt aaaataacca    300
 atgactgccc agaacacctt gaatcaattg atgtcatgtg tcaagtgctt actgatttga    360
 ttgatgaaga agtaaaaagt ggcatcaaga agaacaggat attaatagga ggattctcta    420
 tgggaggatg catggcaatg catttagcat atagaaatca tcaagatgtg gcaggagtat    480
 ttgctctttc tagttttctg aataaagcat ctgctgttta ccaggctctt cagaagagta    540
 atggtgtact tcctgaatta tttcagtgtc atggtactgc agatgagtta gttcttcatt    600
 cttgggcaga agagacaaac tcaatgttaa aatctctagg agtgaccacg aagtttcata    660
 gttttccaaa tgtttaccat gagctaagca aaactgagtt agacatattg aagttatgga    720
 ttcttacaaa gctgccagga gaaatggaaa aacaaaaatg aatgaatcaa gagtgatttg    780
 ttaatgtaag tgtaatgtct ttgtgaaaag tgatttttac tgccaaatta taatgataat    840
 taaaatatta agaaataaca ctttcctgac ttttttatta ttaaaatgct tatcactgta    900
 gacagtagct aatcttatta atgaaaaaca atagacaaac atctgtgcat aatttttcag    960
 acacaattct gtaaatattt ggaaaccttt taagtattta aacttttaaa tttttgaaat   1020
 aaagtattct aaactaatat aaataaggac aatgaaaaaa catgaaagga cttagcataa   1080
 tgttatttta tcttttctac aactttgttt aaattacctt tccaaagata tttgtgttta   1140
 tgtaattttc cacggaataa cattaatact ctaggtttat aaaccggttt cacattattt   1200
 catttgatca tcacaagagc tttgtgaagt aagccgagaa gttgttactg gtatttaata   1260
 atagcaatag aggagttaaa gactttccca cagcttgcag gtcaagacaa gaaattcagg   1320
 tctcctaatt ctcagtggag ctctatttct gttaacccaa attgctgctc tgttttaggt   1380
 ctcaatttca tctgtaaaat gatactaata gtacttatcc cattggattt ttgttgagat   1440
 ttaaataaat agccaaaagc caatacataa taaacactca ataaagatta accataagga   1500
 gagtcatgat ctggttccag gaatacattg ttagatgact gaaaaattgt attacttcaa   1560
 tgaaaatact ataaataata acattttcat atattagttg gttctcatgc atacataatc   1620
 taattttatt tgatcctcac aactgtttaa gttttattaa atatacatta tccctatttg   1680
 tataaataga atcatacaat acctgcctgc tttcattcaa caaaattatc atgagatttt   1740
 tccatgttgt gtacatcaat agttcatcta ttttattgct cagtaatatt ccattgtgtg   1800
 gatgtatcac tatttgttta cacattcacc actgatatat aagttgcttc cagtgtgagg   1860
 ctgttttaaa taaagctgct atgaatattc aaaaaaaaa                          1899



      <210> 1896
      <211> 1542
      <212> DNA
      <213> Homo sapiens


      <400> 1896
 tttcgtgtgg actggggccg gataatggcg ggcgctgcag aagatgcgcg agctcttttc     60
 cgggctgggg tctgcgcggc cctggaggcc tggccggcct tgcagatcgc tgtggagaat    120
 ggcttcgggg gtgtgcacag ccaggagaag gccaagtggc tggggggtgc agtggaggat    180
 tacttcatgc gcaatgctga cttggagcta gatgaggtgg aagacttcct tggagagctg    240
 ttgaccaacg agtttgatac agttgtggaa gacgggagtc tgccccaggt gagccagcaa    300
 ctgcagacca tgttccacca cttccagagg ggtgatgggg ctgctctgag ggagatggcc    360
 tcctgcatca ctcagagaaa atgcaaggtc acagccactg cacttaagac agctagagag    420
 actgatgagg atgaagatga tgtggacagt gtggaagaga tggaggtcac agctacgaat    480
 gatggggctg ctacagatgg ggtctgcccc cagcctgaac cctctgatcc agacgctcag    540
 actattaagg aagaggatat agtggaagat ggctggacca ttgtccggag aaaaaaatga    600
 gtggggatga ttggaaatgg ctttgggccc ttatttgctg ttctaagagt tgtctgtagg    660
 ggtttttttt tttgaggatt gaagacctgt gggacttggt taccccatct ccaccctctc    720
 ccctgttcct ctgtctggct ccctccaggg caaggaaaac ctagggtcct tggtcttggg    780
 ggtgggggga ccttttccag catattcccc tgggccttta gttaacatcc gagtgacgaa    840
 gccgggttcc ccagtacagt gtcttttggg tgcggtcatt gtgaggaagg ggatgagtga    900
 gtgtgggtgt ggctggagga ggagctagat gccggtggac agtgggcagg tggatttggg    960
 gaggagagga tcagcagcag cagcagtact cagtgatagg gggctggctg ggtcaggaat   1020
 ggtgagatga acatgcaagt ggaagagaga atagttgaaa atgtgaatga aagtagctct   1080
 ggagcctctc ccttacccca ccccacacac acgcaacagc tctgtacccc tgcccagaac   1140
 ttggaacctc ccaggaatgc tgccttcctt cagcccagcc tccagtcctg ggttccctca   1200
 ggaattcgaa gaccttggct aggtggtgag cttggaagag ctgggctttg ttttctgtct   1260
 cctctaacct ctttccttac tccttatccc atcccatttg agttcagggg tgaggcttaa   1320
 gatcttaata aataatacct tactgcttaa tctgtggctt gacctgtgag tagtagcctt   1380
 agaatcagcc ttctgggagc tcagcttcag agtttacaag ggagcagttt ctgggcccac   1440
 cctagcagcc tgggtacttt ggacaaccaa acagatgaac gaacggagca cagcagtgct   1500
 atgaaagtta ctgtaagcct gaaaataaac tggtattttt ct                      1542



      <210> 1897
      <211> 1180
      <212> DNA
      <213> Homo sapiens


      <400> 1897
 tttttttttt tttttgtcct attacctcct ctgagcgcaa atcactggct acaagggact     60
 taccagtctg gattcagcag tttcttttct aaaacccatt tgggtgactc agcagccgca    120
 tctgctacct gattttatcc tggagaatac agtgcaatat ttctctttga ttatttattc    180
 ctcttgattg tggaattaat ttgattgctt gctaatggta ctagtagtac tcctttcaga    240
 agaaaaaatg gagcgattta ggtgaccaaa tattacatac ataaatagcc acatgaagtt    300
 ttagacgttt ggacttgaag cctcaaagat caaccaacca gtccccttat ttagtaaata    360
 aggaaattga ggctacacac agaaaattgt actacagatt attactaata acccagcttg    420
 ctaaattagg ctatacctag gtaatctcta gaagacaact ctgacagact ctttaatatt    480
 tacccctggt tggaacaata tttgaaatgt cccagatatt tctatgctac ttagatattt    540
 gtggcaaagc agaaagcttt ttgactgtga aggcagaggt cagcactggg ggaaacttgc    600
 tggtggtctc tcccacaacc ttgcccagag tcctttccac taaggaggtg aagagaacag    660
 agaaagagat ttccatttct gctgccagag ctggtatttg cctgcctgat tctctgtgtt    720
 tcctgtttca ccgccaccct ttcaggagag aactacacca gttcatcatg agggtcaggg    780
 aagcaaaagc tctcagatgt gtccagggcg ttacttaaga aatgagtatg cagattctgg    840
 aaggggtgtg gaaaaggtga tcctttaccc ccacccagga aaacctgcat tgtgctagca    900
 tggaaaaatc atgggctttg gaattaaacc catttggtgg aattaaaccc atttggtttc    960
 aaatcccagt tatgacatct gttaactttg caaactcaca aaaattattt gaaattatct   1020
 gagttttcat tttctcacct tccagaatgg ggataatgcc tcctgcatcg gttgttgtga   1080
 ggtttcaatg agatgaaata tgggaaagaa gaggtactca cctgatggtc cctgctttcc   1140
 tctgctaggc ctgagtagga agtcgacgcg gccgcgaatt                         1180



      <210> 1898
      <211> 758
      <212> DNA
      <213> Homo sapiens


      <400> 1898
 ttttagaaat acaccagtag taccggacaa accaatctcc aggaaccacc gggttgagcc     60
 gccaaaacag gaatcaggcg cgcagcctcg gccagtcggg aagccactgg cacctatggc    120
 caggcgagaa actgtttact ttctccaccc caccccagat gcacacaatg gagttgatgg    180
 ctttggagat gagaagcgcc accggactgt taaccccgaa gggaagaaaa acaagcaacc    240
 ctaaaccacg ctctgggcag ggctgttaat tgtgccggtg acaaatccga tgattaatgg    300
 gcaggggcag gaggcgcggg gagacggcac gtccgttctg agctggctcc ggggcagcgg    360
 cgcagcttcc caccccgggg ctgggccgcc gaccacgcaa cggttggagg gggctgagga    420
 aaggggacgt cgaacccacc ccagccccac ggctcctttg tccccaaatc cgccgacggt    480
 cctcggaccg cagctcccgc ctcggtgggc ttaagtttct ttgttgtgcg tgttgtcttc    540
 tcctctccgt tttgccagct ggggggaagg gggcgccctc cgtccagccc ctaaagcctc    600
 gcggggaacc gctgttagcg gccacccagc gcaaccacac cggtcccgcg gcggggccca    660
 agcgcgaccg gccccggggc gctgccgagg ttccagcagc cccgacggcc ggactctgac    720
 ccagggatgt ggggcccgcg tccggacgcg tgggtcga                            758



      <210> 1899
      <211> 919
      <212> DNA
      <213> Homo sapiens


      <400> 1899
 atacagagat gtgatgctgg agaactataa gaatctagtt gcagtagatt gggagagtca     60
 tattaatacc aaatggtcag cacctcagca gaattttttg caggggaaaa catccagtgt    120
 ggtggaaatg aattcagagt aaaagggaga atctcaatga aataaatttg gaaaacttct    180
 atgaaccatc attaattttc accaacagga gagaaaccat tttggagagg aactgtttga    240
 ctttaaccaa tgtgaaaaag ccttgagtga acactcatgc cttaagactc acaggagaac    300
 ttactttaga aagaaaacct gtgagtgtaa tcaatgtgaa aaagccttca gaaaaccctc    360
 tatctttact ttacacaaga aaactgatat cggagaggaa cttcctaact gtaatcaatg    420
 tgaaacagcc ttcagccaac atctacatct tgtttgcaag aaaactagcc aaaatctaca    480
 tcttgtttgc aagaaaactc acactcaaga gaaaccatat aaatgcagtg actgtgaaaa    540
 aggcttacct tcctcctcac acctcagaga atgtgtaaga atttatggtg gagagagacc    600
 atatactcat aaggagtatg tcgaaacctt ttctcattct acagcccttt ttgtacacat    660
 gcaaactcaa gatggagaaa aattctatga atgtaaagca tgtgggaaac ccttcactga    720
 gtcgtcatat cttactcaac atttaagaac tcatagtaga gtgttaccta tagaacataa    780
 gaaatttggc aaagcctttg ctttttcccc agatcttgct aaacatataa aacttaaaac    840
 tagaggaaaa cactatgttt gtaatgaatg tggcaaagaa tttacttgtt tctcaaaact    900
 caacattcac ataaggggg                                                 919



      <210> 1900
      <211> 4413
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> misc_feature
      <222> (1)...(4413)
      <223> n = a,t,c or g


      <400> 1900
 actcggccgg cagcggaccg cagccaccag ccgcccgcgc cctccagccc cgtccgggag     60
 tccccggccc gctgcggtgc cgtgagtacc tccaaccccc tgcgccccgg agggaggccg    120
 aggggcttag ccaccagggc tcggaagtgg gggccgaatc cggtgcgaga cccaaggaga    180
 ggggagcaga gccggagttg gggagactgt ggctgaaaac tgtgtcttcc tggagactag    240
 gctggcattt tgactttggg gttgctgaaa agccaggagt caaaatgact gagcgctttg    300
 actgccacca ttgcaacgaa tctctctttg gcaagaagta catcctgcgg gaggagagcc    360
 cctactgcgt ggtgtgcttt gagaccctgt tcgccaacac ctgcgaggag tgtgggaagc    420
 ccatcggctg tgactgcaag gtgcaacatt agaggaaatc aatcagcact gggactggct    480
 ggaacaaaat ctcctccaca ccttgtctgt ctttgataat aaagatgaca ttgccagttt    540
 tgtcaaaggg aaggtaaagc cgtgtgtctg ggtggctgac ggatgacaca gctgagccat    600
 tctcctcatc aggtgtgact gtcgttgaag cagcgcacac ttctcggggg cctgtgcacc    660
 tcagtccctc ctgcttcctg tcccttgcac cccctgcctt cccattgctg gctcactgag    720
 cagggactgt catctctgtg tgtcaggctc tgatagccga ggagaccagc agcaggctcg    780
 ccgagcagga ggaggaaccc gagaaattcc gagaagccct ggtgaagttc gaggccaggt    840
 tcaacttccc cgaggcggag aagctggtca cctactactc ctgctgctgt tggaagggca    900
 gggtgccccg ccagggctgg ctgtacctca gcatcaacca cctctgcttc tactccttct    960
 tcctgggcaa ggaacttaaa cttgtggttc cgtgggttga tatccagaaa ttagaaagaa   1020
 cgtccaatgt ctttctgacg gataccatcc gaatcaccac gcagaataag gagcgtgact   1080
 tctccatgtt cctgaacctg gatgaggtgt ttaaggtcat ggagcagctg gccgacgtga   1140
 cgctgcgaag gctgctggat aatgaggtct ttgacctcga ccccgatctg caggagccga   1200
 gccagatcac caagagggac ctggaagcca gagcacagaa tgagttcttc cgggctttct   1260
 tcaggttgcc gaggaaggag aagctgcacg cggttgtgga ctgttcgctc tggacgccgt   1320
 tcagtcgctg tcacaccgcg gggcggatgt tcgcctctga cagctacatc tgctttgcca   1380
 gcagagaaga tggctgctgt aagatcatcc tgccactcag agaggtggtg agcatcgaga   1440
 agatggagga cacgagcctg ctgccgcatc ccatcattgt cagtatcaga agcaaggtgg   1500
 ccttccagtt cattgagctc cgggaccgag acagcctggt ggaggcgctg cttgcgaggt   1560
 tgaagcaggt ccacgccaac caccccgtgc actacgacac ctctgcggat gatgacatgg   1620
 cttcactcgt gtttcattca acaaggcatg tgccagtgac cacagatttg gggatcctga   1680
 aataatgtct tctcaaaata gcgaggagag tgagaaagag aagagcccgc tgatgcaccc   1740
 cgatgnccct ggtcaccgcc ttccagcagt caggcagcca gagccctgac tcccgaatgt   1800
 ccagagaaca gataaaaata agcctgtgga atgaccactt tgtggaatac ggcagaaccg   1860
 tgtgtatgtt tcgcacagag aagattcgga agctcgtagc catgggcatc cctgaatctt   1920
 tgcgagggag actctggctt ctcttctcag atgcggtgac ggatcttgcc tcacaccctg   1980
 gttactacgg gaatctggtg gaggagtccc tggggaaatg ctgcctggta accgaggaga   2040
 tagaacgaga cctgcaccgc tccctgccag agcaccccgc cttccagaac gaaacgggaa   2100
 ttgctgcttt gaggagagtc ttgacggcct atgcccaccg gaaccccaag attggatact   2160
 gccagtccat gaacatcctg acctccgtgc tgctgctgta caccaaggag gaggaagcct   2220
 tctggctgtt ggttgctgtg tgtgagcgga tgctgcccga ttacttcaac caccgagtga   2280
 tcggggcaca agttgaccag tctgtcttcg aggagctcat caagggtcat ctcccagagc   2340
 tggcagagca catgaacgac ctctcagccc tggcgtccgt ctctctctcg tggttcctga   2400
 ccctgttcct cagcatcatg cctctagaga gtgcggtgaa tgtggtagac tgcttcttct   2460
 atgatggcat caaagccatc ttccagctgg gactggctgt gcttgaggcc aatgctgagg   2520
 acctgtgcag cagcaaggat gatggccagg ccttgatgat cctcagcagg tttctagatc   2580
 acattaagaa tgaggacagc ccagggcccc cagttggcag ccaccatgcc tttttctccg   2640
 acgaccagga gccctaccct gtgactgata tttcggacct gatccgggat tcctatgaga   2700
 aatttggaga ccagtctgtg gagcagatcg agcacctacg ttacaagcac aggatcaggg   2760
 tcctccaagg ccacgaggac accacaaagc agaacgtgct tcgagtcgtt atcccggaag   2820
 tctcaattct tcctgaagac ctagaggagc tctacgactt attcaagaga gaacatatga   2880
 tgagctgtta ctgggagcag cccaggccca tggcctcacg ccacgacccc agccggccct   2940
 atgctgagca gtaccgcata gacgcccggc agtttgcaca cctgtttcag ctagtctcgc   3000
 cctggacctg cggggcccac acggagatcc tcgccgaaag gacgttcagg ctcttggatg   3060
 acaacatgga ccagctcatc gagttcaaag cgtttgtgag ctgcctcgat attatgtata   3120
 atggagaaat gaatgagaag attaaactat tatacaggct tcatatccct ccagcactca   3180
 ctgaaaatga ccgagacagc cagtcgccgt tgaggaatcc tctgttgtca acatcgagac   3240
 ccctggtttt cgggaaaccc aatggtgatg cagttgatta tcagaaacag ctgaagcaga   3300
 tgattaagga tttagccaaa gaaaaagata aaactgagaa agaattgccc aaaatgagcc   3360
 agagagaatt tatccagttc tgtaaaactc tgtacagtat gttccatgaa gatccagaag   3420
 aaaatgattt gtatcaagcc atcgccacag tcaccacact gctgctgcag atcggggagg   3480
 tggggcagcg aggcagcagc tctggaagct gctcccagga gtgtggggag gagctgcggg   3540
 cttcagctcc ttctcctgag gactcggttt ttgcagacac tgggaagacg ccccaggact   3600
 cccaggcatt tccagaggcg gcagaaaggg actggactgt ctcccttgaa catattttag   3660
 cttcacttct gactgaacag tcattagtca acttttttga aaagccactg gacatgaaat   3720
 ccaaacttga aaatgccaag atcaatcagt acaatctcaa aacttttgaa atgagccacc   3780
 aatcacaatc tgaacttaag ctgagtaact tgtagcaaga cagcagctgc tatgcacact   3840
 ggagtccacc ataccaaagc acgaaccaga ctgtttcttg gggtcagccc taaaccgaga   3900
 tttcagtcta ccttaccaat ggggcatctg gctaaacaac ctgacaaact gtggccaggg   3960
 gaaccgacac aaccctcaag catttctatg tattgagaat tgtcagtgcc ctaaggtatc   4020
 cattggttcc cttgatgcca acttacaatt tttaccggat ttgctgaaat gggcacttct   4080
 gctgtgatgc tagtgttgat tttgctctca gatgaacaca atgtctcata ctaaccaaga   4140
 agcaagaaaa gccccatgct ttcatttttc acttggagtg acaatgggag aggtcaggaa   4200
 tcaagttcac tttcaagatc taagggagtc cactatctgt gcaattgtat ttggcttttt   4260
 tttgcactgt ttcaatgctg gtaattgaaa ccattttaat atatttggtt gtattcactt   4320
 tatatgtcct tccaaaaatg ttgttgtgta cataccatgc tttcaatgtt ggcttccaag   4380
 ttttttaata agaaactttt tgtaaaaaaa aaa                                4413



      <210> 1901
      <211> 560
      <212> DNA
      <213> Homo sapiens


      <400> 1901
 tcaacacagc ctctgcaggt tccaaccagg agatgaagcc aggcactggt gtggcaagag     60
 caccgaggca cgcttcctga gaggcacagt cacatccgtg gctgtcgcgg ccatcgggct    120
 gccgctgcca ccgctgtgga agctctcgga ggccctgaga cgggagaaca tggtgagagc    180
 gtcagggaag ttggggggtg tagcaggggt attggcgggg gtgcacatca tctggtggtg    240
 atggtggctg taggggatgt tggtctcctg gaaaaaggcg ctgagggctg tctcgaactg    300
 ccagtgggcc gcctgcagca gttgcttcgc ctggtcggcc gcgcagcccg ccgtcagcac    360
 gaactggttg atcatgacct ggtgcttgag ctcgtccatg ttcacggaca tggcgccgcc    420
 gcgctgcccg ctccggcctc cctccgccgc ccgcgcctcc gcctcacgcg tccaccatta    480
 gcgagccggc tccggctaat acaaatattt actgtgcggc tctgactcac cgcgccacga    540
 aatcgtcgac ccgggaattc                                                560



      <210> 1902
      <211> 785
      <212> DNA
      <213> Homo sapiens


      <400> 1902
 gagtggcgta gacgagttaa gtcctggtct gcgtggaggt cgacgactcc gtcgcagact     60
 acggacctgt ctgggtctca gccgccaaag accccgtccg gtagtcattg ctattatctc    120
 gattgaatta ctttctaata ggaagtacta gccggacatc atgagtggct gtcgggtatt    180
 catcgggaga ctaaatccag cggccaggga gaaggacgtg gaaagattct tcaagggata    240
 tggacggata agagatattg atctgaaaag aggctttggt tttgtggaat ttgaggatcc    300
 aaaaggatgc agatgatgct gtgtatgagc ttgatggaaa agaactctgg tagtgaaagg    360
 gttactattg aacatgctag ggctcggtca cgaggtggaa gaggtagagg acgatactct    420
 gaccgtttta gtagtcgcag acctcgaaat gatagacgaa atgctccacc tgtaagaaca    480
 gaaaatcgtc ttatagttga gaatttatcc tcaagagtca gctggcaggt ttgttgaaat    540
 acagttttga gttattttga tgtggctttt taaaaaagtt aatgggtagc taatgttgta    600
 ttgttttatt aaaagtagtt ttaaattaat ggatttaatg gaattgtaat tttaaacatt    660
 taattaaatg taatttgggg gatattttga actttaatat tagtgatcaa atgtaaatgt    720
 tttgaggata tttttcttgt tttttaaaat caatttttaa ccaaatatta aaccctttat    780
 ttgcc                                                                785



      <210> 1903
      <211> 365
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> misc_feature
      <222> (1)...(365)
      <223> n = a,t,c or g


      <400> 1903
 attctcttat gtttactaag ggccgagaac cacttaaaag cttttccaca ttcattacat     60
 gtgtagggtt tgtctccagt atgaattatc ttatgtttag caaggtctga gaaccaccta    120
 taggctttgt tacattcttc acatttgtag ggtttctctc cagtatgaat tctcttatga    180
 ttagtaaggt ctgagaagca cttaaaggct ttgccacatt cttcacattt gtagggtctg    240
 tctccagtat gatttctctt gtgtttaaca agggttgagg agcaggtaaa agttttgcca    300
 catccttcac atttgtaagg tttctctcca gtatgaactc tcttatgttc agtaaggttt    360
 gaaan                                                                365



      <210> 1904
      <211> 437
      <212> DNA
      <213> Homo sapiens


      <400> 1904
 tttcgtgaaa aatggaatag tgtagctgac tgcctgccct gtgttttcct ggtggatttt     60
 gaatttgggt gtgctacatc atacattctt ccagaacttc aggatgggct atcttttcat    120
 gtctctattg ccaaaaatga caccatctat attttaggag gacattcact tgccaataat    180
 atccggcctg ccaacctgta cagaataagg gttgatcttc ccctgggtag cccagctgtg    240
 aattgcacag tcttgccagg aggaatctct gtctccagtg caatcctgac tcaaactaac    300
 aatgatgaat ttgttattgt tggtggctat cagcttgaaa atcaaaaaag aatgatctgc    360
 aacatcatct ctttagagga caacaagata gaaattcgtg agatggagac cccagattgg    420
 accccagaca ttaagca                                                   437



      <210> 1905
      <211> 2019
      <212> DNA
      <213> Homo sapiens


      <400> 1905
 tcagcgctga cgaggtctgc cgaggacgcg tttctctctg cagcccggca ccagtctcaa     60
 ggccatcggc tccgacagcg tcacctcctg ggaccttccc ttcatgtatg gtcccagcgg    120
 catgcgggcc tggtggagga ggtcctggcc tgccgcccag ggatggccgg tccaggcgca    180
 gggccgattg tccacttctg gcccctcctg ggtccctgtc cgtcgggaag tcaggaagaa    240
 gacgccgagt gaggtcacgg tgcccacgag ggtggattcc cctcggcctg accacgccag    300
 gaggtggccg aagggaagag ggtggggcag gggctgctct gcaccctcta gcagagcggc    360
 atccctgcag gtgtttgctc tgacgaggag aagccccaga gagcagttcg ggactgtgcg    420
 gattggcttt agggagccag cttttaaaac gcgttggccc acggcctcct gcggcctggt    480
 cactggggac gggagcaggt atgcctggtc cctgtgctgg gccccacggg atgtaaagaa    540
 gggccacctg ggcacggcgg ggcctgcggt gcgggctggc ctgtgggctc cacagggttc    600
 catgcaggca ttttgctccc ataccccgat gtccaagccc ggcctgctct cccctggaac    660
 gcctggaact agggtggtca ggctggggtg gaggagctcc cctggaatgt tccagagctt    720
 cccccactcc tgccgttctg agtcaccctg cctccccgga ggaggaggag gatcagctga    780
 gccgccgcgc tcacgtagtg tctggctgtc tgcctgtctg cctcgctgtg agcagagtgg    840
 gatgctgccg ataaggcgca cgtgggccct gggaggagcc cgaggcagcc actcccgcac    900
 gtgggcagga ggagggctgc tcacaccacc ggccgaggga ggaggactgc gggctgcgcc    960
 cctgccccag ccaggaccct ctgcatcctt tccatccttg gcccatggtg tgtcctgcca   1020
 catcttccca ctctgtgcct gggccaggcc caggcagcgt cctgcagcca gggtgctcac   1080
 ggctgctttg ccggctgttc ctgcactgca cgtctgcgtc acatccggtt tttgtaagtg   1140
 cccgttacac cctgtgtgca cacttgcgga cgtgcacggc tgcatcacat ccggtttttc   1200
 tgtgatttct ttgccacaga cctgcgcccc ctggacatcc tggcggaagt ggtccctttc   1260
 tgactcctgg caggtggacg cctgcccaga gagctgctgt gagcccccct gctgcgccac   1320
 cagctgctgc gccccggccc cctgcctgac cctggtctgc accccagtga gctgtgtgtc   1380
 cagcccctgc tgccaggcgg cctgtgagcc cagcccctgc cagtcaggct gcaccagctc   1440
 ctgcacgccc tcgtgctgcc agcagtctag ctgccagcca gcttgctgca catcctcccc   1500
 ctgccagcag gcctgctgcg tgcctgtctg ctgcaagcca gtctgctgtg tgcccgtctg   1560
 ctgcaagcct gtctgctgca agcccatctg ctgtgtgccc gtctgctctg gggcttcctc   1620
 ttcatgctgc cagcagtcta gccgccagcc ggcttgctgc accacctcct gctgcagacc   1680
 ctcctcctcc gtgtccctcc tctgccgccc cgtgtgcagg tccacctgct gtgtgcccat   1740
 cccctcctgc tgtgcccctg cctccacctg ccagcccagc tgctgccgcc cggcctcctg   1800
 cgtgtccctc ctctgccgcc ccacgtgctc ccgcctctct tccgcgtgct gcggcctctc   1860
 ctcaggccag aagtccagct gctgacgggc aggtcccgtt tctccagagt tgttccaggg   1920
 ccatctctga cttccgaaaa tccttgcagc cctgagccct gtctgagtct cctctgccca   1980
 tagccactgc acctccagcc agcaatgctg agctttcat                          2019



      <210> 1906
      <211> 433
      <212> DNA
      <213> Homo sapiens


      <400> 1906
 ccgtttcctc atctctgaac agatgggcct ggtgcactaa gatcccagcc tgaagggaaa     60
 tctcttagca gatctgctta gcgaggcttc ttagaactgc cccttcaccc tccccagcca    120
 cagtgggggc ccccagacag catgtgcatc ctggacacag ctcatcgggc aaggggggca    180
 cctatgtagg ctgggccaat gagtccctgc ccaagggaat ttagagttgg aaataaggga    240
 atggtggagc agcagctgcc atgttgccaa ccccttctcc caccaaaaag agagaaagat    300
 gctccagaac aagagaaaga agtcaagcaa gggggcagaa aagcagggac tgtaacaggt    360
 ttggggtttc tttggaggtg cgatatgctc aagaattagg ataaggatca tcactcgtgc    420
 cgaattcctg cag                                                       433



      <210> 1907
      <211> 478
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> misc_feature
      <222> (1)...(478)
      <223> n = a,t,c or g


      <400> 1907
 gggggggaaa ccggtgtaat tattagccat ggtcaaaccc caccgtgttn tttngacatt     60
 gccgtcgacg ggcgagccct tgggccgcgt ntcctttgag ctgtttgcag acaaggtccc    120
 aaagacagca ggttggatgg caagcatgtg gtgtttggca aagtgaaaga aggcatgaat    180
 attgtggagg ccatggagcg ctttgggtcc aggaatggca agaccagcaa gaagatcacc    240
 attgctgact gtggacaact cgaataagtt tgacttgtgt tttatcttaa ccaccagatc    300
 attccttctg tagctcagga gagcacccct ccaccccatt tgctcgcagt atcctagaat    360
 ctttgtgctc tcgctgcagt tccctttggg ttccatgttt tccttgttcc ctcccatgcc    420
 tagctggatt gcagagttaa gtttatgatt atgaaataaa aactaaataa caaaaaaa      478



      <210> 1908
      <211> 2170
      <212> DNA
      <213> Homo sapiens


      <400> 1908
 atgccaagaa gccatacggg agagagactc tgtgaaggta aagaaggtag tcaatgtgca     60
 gaaaacttca gtcccaatct cagtgtgacg aagaagactg ccggagtaaa accatatgag    120
 tgtactatct gtggaaaagc cttcatgcgt ctctcatccc ttactagaca catgaggtct    180
 cacactgcca tacgagctat ttgagaagcc atataaatgt aaggagtgtg agaagagcct    240
 ttagtttatc tcaaatcctt tcaaagacat gaaaggagtc acactggaga aaaaccctat    300
 aaatgtaaac aatgtggaaa aaccttcata tatcaccagc cctttcaaag acatgagcgg    360
 actcacattg gagaaaaacc ctatgaatgt aagcaatgtg gaaaagctct tagttgttcc    420
 agttcgcttc gagttcatga aaggattcac actggagaaa agccctatga atgtaaacaa    480
 tgtgggaaag ccttcagttg ttccagttct attcgagtac acgaaagaac tcacactgga    540
 gagaaaccct atgcatgtaa gggaatgtgg gaaagccttc atttcccaca acaagtgttc    600
 ttacacacat gataacacac aacggagata gaccttataa atgcaaagaa tgtggaaagg    660
 cattcatttt tcccagtttt ttacgagtac atgaaagaat tcacactgga gagaaaccct    720
 ataaatgtaa acaatgtggt aaagccttca gatgttccac ctccattcaa attcatgaaa    780
 gaattcatac tggagagaag ccctataaat gtaaagaatg tgggaaatct ttcagtgcac    840
 gcccagcctt tcgagtacac gtgagagtgc atactggaga gaaaccctat aagtgtaaag    900
 aatgtgggaa agcctttagt agaatcagtt actttcgaat acatgaaagg actcacactg    960
 gagagaaacc ctacgaatgt aaaaaatgtg ggaaaacttt caattatcct ctagatttga   1020
 aaatccacaa gagaaatcac actggagaaa aaccctatga gtgtaaggaa tgtgcaaaaa   1080
 ccttcatttc tcttgagaac tttcgaagac acatgatcac ccacactgga gacggacctt   1140
 ataaatgtag ggactgtggg aaggtgttca tttttcctag tgcgttacga acacatgaaa   1200
 gaactcacac tggagagaaa ccctatgaat gtaaacaatg tggaaaagcc tttagttgtt   1260
 ctagttacat tcggatacat aaaagaactc acactgggga gaaaacctta tgaatgtaag   1320
 gaatgcggga aggcctttat ttatcccaca agctttcaag gacacatgag aatgcatact   1380
 ggagagaaac cctataaatg taaagaatgt gggaaggcct ttagtcttca cagttccttt   1440
 cgagagacat acaagaattc acaattatga gaaacctctt gaatgttagc agatgtggaa   1500
 aagccttcag tgtgtccaca tccttaaaaa aacctatgag gaatgcgcaa tccgatagga   1560
 aactctataa tgtgagaaat aggagaaagt tttcaattct aacagatgct ttcaaagttg   1620
 tgaaaattcc cactgaagag agaaatcctg tcaatgtaag taatatagaa agcgagatac   1680
 aagatgattc atgtatagtc aggtaccaca taatcatgtt tcagtcagca atggaccata   1740
 taggttggta gccccataag attatataac acctaaaaca tttctatcaa ccgcaattta   1800
 gtagcagtag taacaccata gtgcagcaca ttatttaagt gtttatggtg ctggtgtaaa   1860
 cgtgctgcac tttcagttgt ataaaagtac aagacagcgg ccggggacgg tggctcacgc   1920
 ctgtaatccc agcactttgg gaggccaagg cgggcggatc acgaggccag gagatcaaga   1980
 ccatcctggc taacacggta aaaccccatc tctactaaaa atacaaaaaa ttagccgggc   2040
 gtggtggtgg gcgcctgtag tcccagctac ttgggaggct gaggcaggag aatggcataa   2100
 acccaggagg ccgagctgac agtgagctga gatccggcca acagagcgag actctgtctc   2160
 aaaaaaaaaa                                                          2170



      <210> 1909
      <211> 438
      <212> DNA
      <213> Homo sapiens


      <400> 1909
 aagtgagctt cctctcctcc ttcttcctca gcctgcccta tggtgtggca gtgggtgtcg     60
 ccttctccgt cctggtcgtg gtcttccaga ctcagtttcg aaatggctat gcactggccc    120
 aggtcatgga cactgacatt tatgtgaatc ccaagaccta taatagggcc caggatatcc    180
 aggggattaa aatcatcacg tactgctccc ctctctactt tgccaactca gagatcttca    240
 ggcaaaaggt catcgccaag acaggcatgg acccccagaa agtattacta gccaagcaaa    300
 aatacctcaa gaagcaggag aagcggagaa tgaggcccac acaacagagg aggtctctat    360
 tcatgaaaac caagactgtc tccctgcagg agctgcagca ggactttgag aatgcgcccc    420
 ccaccgaccc catgtatt                                                  438



      <210> 1910
      <211> 1696
      <212> DNA
      <213> Homo sapiens


      <400> 1910
 tttttttttt ttgcaggacc acaaaatgga actttattca gtcacagaca ctgaccctcc     60
 aatagcccca gaagcaagag cctagggccc agcaatccat acccagtcct tggagttggg    120
 cagggtagga cgctggccaa gggccagtgc tgtctcttgc ttacagcctg aggactacgg    180
 gagcagcagc tgtggcctgg ccgctcccaa tgctgggggc ttggcttggt gccccatccc    240
 cttcctgact gagctctatg aaggactctt aaaaaaataa aataaaatgc aagcaaagtg    300
 ctttgaaaga agggaggaca ccctattcct gctaaggggt agaggaagaa ggtgaaggcg    360
 gctaggtgcc cataagagaa ggctggcaca atcttcattc ccgccagtgt gatttcagtc    420
 tcaaaagatg agtatttggc tgagaaatgg aaggatactc caggctccct acggagttgt    480
 gctggggcca tgctgagctg cccttgcagg cagccctggg tgctgggggc agacatgcag    540
 gacactggga agagtcagaa ccacaggtgg gagggaatct cagagcccag gctccccact    600
 gagcttggcc agcagctttg aactccttca gaggaccctt tcattttctt cctatgtcct    660
 tatcgtccat acatcccaaa tactaggaag ctgaagaaga cggtgactcc caccagggag    720
 acagtggcag gtgctgtgaa gaattggcgg taattgattc ggaagtacca gaccacaccc    780
 aacagcacca caaagacagg caccatgagg ctgcccacat tgacaccaag gctgggtggc    840
 tcagtggccg agggggccaa ggaggctgag gggcctggaa cagctgaccc tgggggtgag    900
 cggtggcagt gaatcacaca gttgtcggta atgttcagag aacgcagtgt gcgggctggg    960
 tcttgtagca ggcggccctg gtagatcagt ttcatctggc tttcttgtcc agggaagtat   1020
 ttgctcttca gggcacccac ggtatcctct ggcctagcca cagccagctc ctcggtatca   1080
 ttgaggaatt tgagccgcac agtgatgagg ccagggctgg gagggaggca ggtgctatcc   1140
 tcagatctca ggggggcctc tggactgctg ctgcctgcac ctgcttgtct tttgggcagg   1200
 ccttggatgt caaggagatg ctcaaggctg ggctcaacac cacccccagc tccagcctcc   1260
 ccagtggagt ctccccgacc ttcacccgcc tcttcagcct tctcatcatt accctctgat   1320
 ggatggggga gttcagttgg ctcggggttg ccttggcctg ccaccaggtg gtccacatgc   1380
 cccaggtgga ggacggatgt gtcgcctgct gacacaatag cgcccaggag ctggttgcta   1440
 ccgctgtctg ctacgtaggt agagagccaa gctaggacca aggctagaat cagcaccacc   1500
 acacctgcca ccaccatcac ctcattaccc acaccctcaa tgagggtgac atcagagagc   1560
 tccatggcct ggctgctggc agggtccacg ctgaaaagac cagactaaat gttttgacct   1620
 cgccaggacg gcccctggac tcgtctttcc gtaggggtcg ggaaaagggc tggcaatctg   1680
 cgattctgtt cagggt                                                   1696



      <210> 1911
      <211> 2368
      <212> DNA
      <213> Homo sapiens


      <400> 1911
 acttagtgca tagactttat caaatgttga ataaaaacag aaacaaaaag gagacaatcc     60
 tacaatgaaa aggagacact caggtccacc ctagtgattc cttgtatgtg gaggaggtaa    120
 gtgggacatg gacagttcta aaatatagta cgtatatacc cgacaaccac agtgttttgc    180
 atttctttat cagtgaaaaa caaactgata tctgaagtgt ataaacagtt ccctagtagt    240
 ctatttgaga aaaagtatca aatgtgcatc aatatgttaa aactgacaaa tacaagaaaa    300
 gcattcagct agagaaaatt cacagcattt tattcaagtt aatcaatttc attcaataat    360
 ctgccatatt gttcccagca ccactattac tgttattatt tctctttgag gaagaccagg    420
 tattaagaaa tctggtttga atttccatga tgcctaactc tatggttaaa aatccttttc    480
 cttaccaaaa aggaacttct taatcaccag agaaacagag ggaagactga gatatgtttg    540
 cagaaattta tctctactag agacaattca tagttcataa tctttcaggg ttgtgcttta    600
 cttgggggct ccgttttcgg gagcgggttg tttcccataa atgtttgctt aatacaaata    660
 atttgcccca ctgtaccaca gaagggaaat gagggctagt gtccccagaa agcaagcagg    720
 cagtcctcca gggaagaagc cctaatggct cctagtggtg acagagtcat tctgcctccc    780
 cagcctgtga gcaataataa agtataacta agtgaacagg agaggtaata actagccaga    840
 taacccatgg gctagaatct ctaaacagaa atgcttgtgt tttgaataaa tcagagctgg    900
 aaagacacac ttttggagaa gtgattgaga atagaaaggt atgaaaaaga taaaggtttc    960
 tcaccaacga aaccacaaaa aaggtggtac cagtcaaagg tagacttggg cttttatttt   1020
 ggggtgaggg taccccaaat gggttgtgcc attttcacat aaaaattgga atgataatga   1080
 acaagtgaaa gtgaaatcag tttccctcct ttgttcaata aacatggtta gagcacctgt   1140
 gtgcaagata gtgggacagg tgctgagggg aaaggtaaag ctgtttaagc tgtggccctg   1200
 agctgaagga gcaatctagc agtgccatca ggccctgcac actgcagagc acagtgtccc   1260
 aggggccagg tggagggaag gatcacttcc ggctgcagca tcagggaagg cactctgcag   1320
 tctcccctcc aggttctcag cgtgcctcta tgcctgtgtg actgctcagc ctgccccatt   1380
 ccaggcactt gctcatcttc cttatctttc tctgtagcat gagaaatgga agtttgagag   1440
 gataggatcc tacctcacag gtacctaata aatgtgtgtg gaattgacat atagtggaag   1500
 tgtcacttta tcttagtgca gcaaggtgga aagagctttg gaaaggagag gaaagatggt   1560
 ggttgtgagg gtaaggtgtt ttcatcagaa ggcgggagca agggtataca aaccaaaaag   1620
 tcagtttagt atgtggctta gctcagagca cacgagggta ccaacacagc caaagactgt   1680
 aagaaggtag ctgaagtcct ctgccaaata ggattgaaaa gctaaaatct ttctctgttt   1740
 ctttcttaag taacaactgg tctattcaag ctcaaccaga gcatataaga gaaaaactga   1800
 ctaacgaggg ggtcttaaag agctttgaag gacagtttct agaaagtaga aagatcactg   1860
 agtaaattac tgcacctcct ctaccccaca aaaaaaaggg tgaggatgaa tgtaaaagtg   1920
 tagagcaagc tttcagacaa cttcaagttt gtttttggcg cttccgtttg taagcaatca   1980
 agatggtgag agacgctatc ccaaagaaga aagtctgtag gaaccagagt agctgagccc   2040
 gaccacttgt gatgccttta tgcttgcaca atactatggc atacaaggac tctcccacat   2100
 gaatcagcca ggcaagccaa tacccattgc acaggagggt gtgatggtgg tccaccaagt   2160
 actgagtgaa ggggcccagg ggcccaaggt tctgataagg gatactctga ggccagaaga   2220
 caacccatgt gtagtagcca aagctgaggg tgatgactgt gaaccagaac agactgcctc   2280
 gctgaaagta ggtcgcgccg gctgccgtag ccatggctgc aacacctccc cgcccacgcg   2340
 tccgcccacg cgtccgccca cgcgtccg                                      2368



      <210> 1912
      <211> 1380
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> misc_feature
      <222> (1)...(1380)
      <223> n = a,t,c or g


      <400> 1912
 caaaacaaaa aacaatattt ccataccttt cctctaatcc caaggaaacc taaagaactt     60
 gattaaaaag ccgtggccaa gagttcgaag tgaaagtcag ccctttagct attatttatt    120
 gctttattag agcagaggga agtgacactc attgccttca cagagctctg cagaaatata    180
 tgcacagagt ggtcaatgac caacatctga gtaagtcttc caaattatca cattaaaata    240
 acctttcaaa tttgagtgcc tctcctttgc aaacaactgc aacctcataa tgaataattt    300
 tatatattat caaaaagaac cagaagccca ggtgcttttt tccccaaaat ccacttacta    360
 aggacttgag tgaaaatcca ctctaagcag atcactgtta ctatttccct ttcaaaacag    420
 ttggaaatcc taaggtacgg gtactaagaa gatagcaata tccttcttaa gctggtaaga    480
 atctagcccc acagggacaa tttggcaatc ctgtttctgg aagccaggac tccagagatt    540
 tgtcttagtg atggacagat actcctctaa ccttaaggca tgagggctgt caaaacaagg    600
 ctctgaatag tgccttcctg ctcatcaatg tcatcacaat gaaggagaga acaggttttc    660
 gttttcctga agagtggtca gtaggagtgc agtggtttgg catagatcgg ctccagaaca    720
 taatggatta aaaccaagaa gaggcctcca aggaagatgg cactaaggaa agccagcagg    780
 acatagcggc caatgaaaaa gtcatccaca atcttaactt ccacttctgg ggctgggaat    840
 tcaccagctc gcgggaaaag caacagaact gatgtgatga tcacagcacc gaagaataaa    900
 aaaatgacag agaacctcgc cgccccggag gctctggaca gcagcacaca cagcagcagc    960
 actgccaccc agagcagggc taagatgaac acgcccgcac cgactccgag cacagtgcca   1020
 gccatcccgc ggggaggcag cggcggcccc ccgccctgcg cgccgcacga tcgagtgtcc   1080
 tctgtgctcc agtgcgacac acaggcaatg gatcacaaga cagaaagttc ccactctgtt   1140
 gtcgagttct tattcaagag gacgaaaact cccagtccct ttcatccagc tgtcagagaa   1200
 aataggaata aatggnctga tccctgcaca ggtaactatc taagacaaat gtggattcct   1260
 cagagggtaa tgtggcctaa gtgctgctgc tggagggaga tatctcaccc atcccccgat   1320
 tctcacactg actcaagccc tctgccccct tcaaaaggat ccactctccc ccaggctcta   1380



      <210> 1913
      <211> 681
      <212> DNA
      <213> Homo sapiens


      <400> 1913
 acgcaattcc cgggtcgacg atttcgtggc ggggccgccg tcgaggctgg cgccagattt     60
 cgattggctg tgggtcctgc agcttcagag aaaggaggcc ttctgtcact cgtcactagc    120
 tcgctcgctc actgggggag gagcccgcct gaggaatccg tgtgcctggg atgccaagag    180
 ccagagaatg gatcttctcc gagtggggac attgctgaca atcccggctt cccgaggcgg    240
 ctaagaacag gcagtttgtg tcggctggct gcagataccc agaggcacaa agagaccgaa    300
 gccacccgga gggacccacg gacggacaga tggtaggcgc gaacccgaga ggaccggcgg    360
 aggctgagca ccgagagccg ccaaggaaga gaaactaacc acagccaagt taccccgccg    420
 gctttccttc gctgcgctaa ggaatgaaac ccttccagct cgatctgctc ttcgtctgct    480
 tcttcctctt cagtcaagag ctgggcctcc agaagagagg atgctgtctg gtgctgggct    540
 acatggccaa ggacaagttt cggagaatga atgaaggcca agtctattcc ttcagccagc    600
 agccccagga ccaggtggtg gtgttcgggg acagccagtg acgctccttt gcgcgattcc    660
 ccgaaaacta ccgcttcgct c                                              681



      <210> 1914
      <211> 420
      <212> DNA
      <213> Homo sapiens


      <400> 1914
 ccaaaaatga aagacagact actgatattt cggttcacgt ttgttgccaa atcttgaaac     60
 gtgggtccca ctatagcaac actcaatccc agccccagga aggaggcaca cagcatcaag    120
 gtggtgaacc accgcagctt gctcccggtc ccaccgctct gccaggagac caccaccacc    180
 tccggctccg gctcattctc cgccggggcc tccgcctgca ggagccgctg ccccgcagcc    240
 gggggcccgg ccccacggag ctccacctct aactccagct cggcggctcc ggagaagtcg    300
 tcttgctgcc gccgcgcttc tcagcagaac ttctggagct ccgagaagag cactggcccc    360
 gaccccaggc acgggtgtcc ctccgggcgc cacctcccag cggaccgccc ggaaacgaaa    420



      <210> 1915
      <211> 1864
      <212> DNA
      <213> Homo sapiens


      <400> 1915
 ccgggacgac gagttcgagg accctcgatc cgagagcgcc ccagccagag cttgtgccca     60
 tgcccctgtc ccgcagggga aggggatccc gcctggccgg ctctcgagcg gcgactagta    120
 acctcccgcg ggcgacagcc ctctccccaa agagtgccgg ccgcggggcc ctgtctgtaa    180
 gccacgcgca actcctcacc cggcggcgcc attcctccga gcaggtcccg ccggagtccg    240
 agccgcgggc tgacttccgc tcgggaaagt ggctccaaga gcccgccaca ggggacgcca    300
 gggactcgcg gcaggctctg cgggccagga tgagttctaa gcacagactt ggacatccct    360
 gacatccctg gactccattg tgagcccctg tcacatagcc ccagacacct gacccaacag    420
 gacccgctca gtgaggccat tgttgagaaa ctgatccagt ccatccagaa ggttttcaat    480
 ggtgagctaa agggtgaact tgaaaagctg aaattcctag gagatctgtc ttctctcagc    540
 caagctttac cttatgatga aaccgcaaaa tcattcattc acagccacat agcagacatt    600
 gtgcatacct taaatgtact ggtacaagag gaacgcccgc attctctgtc cagttccatg    660
 cgccaggagg tctttgtcac catcgctgat ctcagttacc aagatgtcca tttgctgttg    720
 ggctctgaag atcgagctga gttgttcagt cttaccatca agagtataat cactctgccc    780
 tctgtaagga cccttaccca gatacaggaa atcatgccca atgggacctg caacacagag    840
 tgtctttaca ggcagacgtt tcaggcattc tctgagatgc tccagagttt ggtggtaaaa    900
 gacccacatt tggaaaatct tgacaccatt attaagcttc cactgcgatt ccaaagactt    960
 ggacacctag tggctctgat ggcactgctc tgtggggacc cacaggaaaa ggtggctgag   1020
 gaggctgcag agggcattca ctccctgctg catatcaccc tgaggctgaa gtatatcact   1080
 catgacaaga aagatcagca aaacttgaaa agagcattga caaaatgtcg agaattcctg   1140
 gagctccaca gctctgccgc taaatgcttc tacaactgtc ccttcagaat tgcccaggtc   1200
 tttgaaggtt ttcttgattc aaatgagctc tgccagttta taatgactac atttgatacc   1260
 ctgaaaaacc tgaaacatcc ctgcatccag cgatcagcag gagaattact gctaactttg   1320
 gcgaaaaata cagagtccca atttgagaag gtgccagaaa ttatgggagt tatctgtgcc   1380
 cagttaccca taatcagcca gcctagagtc cgccaacaaa tcataaatac cgtgagttta   1440
 tttatatcca gacccaagta cacagatata gtgctcagcc ttcccttctg tgtcatccca   1500
 gtgccgtata acaggcacct ggctgaggtg tggagaatgc tgtcggtgga gcttcccagc   1560
 acgaccctgg attctgtgga ggctcctgag gaagctgcag aaatgccata atgagcctgc   1620
 acaggagaag atggcatatg tggctgtggc tgtaagccct tgagctttgc ccctctaatg   1680
 tcagcccctc ccaggatgac tgaccccaca ccccagtgga gagtgttcct tttggtccct   1740
 ctcaaagcct gcatctgtca tccatttata agtctacagt gtttctgcca agggattgac   1800
 atggagggag ctggggagag tgaaggagtc agaatgcctt aatacaaact cgtccaacct   1860
 gcaa                                                                1864



      <210> 1916
      <211> 1404
      <212> DNA
      <213> Homo sapiens


      <400> 1916
 cggcgggcgg tggctttggg gccgaagtgg gcgtgcggct cgcgctgttc gcggccttcc     60
 tggtgacgga gctgctcccc ccgttccaga gactcatcca gccggaggag atgtggctct    120
 accggaaccc ctacgtggag gcggagtatt tccccaccaa gccgatgttt gttattgcat    180
 ttctctctcc actgtctctg atcttcctgg ccaaatttct caagaaggca gacacaagag    240
 acagcagaca agcctgcctg gctgccagcc ttgccctggc tctgaatggc gtctttacca    300
 acacaataaa actgatcgta gggaggccac gcccagattt cttctaccgc tgcttccctg    360
 atgggctagc ccattctgac ttgatgtgta caggggataa ggacgtggtg aatgagggcc    420
 gaaagagctt ccccagtgga cattcttcct ttgcatttgc tggtctggcc tttgcgtcct    480
 tctacctggc agggaagtta cactgcttca caccacaagg ccgtgggaaa tcttggaggt    540
 tctgtgcctt tctgtcacct ctactttttg cagctgtgat tgcactgtcc cgcacatgtg    600
 actacaagca tcactggcaa ggacccttta aatggtgaaa atgggcagat gaatagcaat    660
 aagtggacct ttgttactct tctgagttag aaaaattcta atttagtaca ctctgaacaa    720
 agcttattat acttacttaa gatgtgtttt gatttggtgt tcagaaagca acctgacaat    780
 gataatactg taactatgat aaaattgaga ataaaaagat tttatttaga aatcataagt    840
 ctggaattga ggttatttta gccccacagt agagtatcct ggagggccag gtcctctatg    900
 ctatgtgtat gtaataggat ttaggagcct aatattaaga gaagaccttg tttccactct    960
 cttcagatgt actagttgga tccatgattg gaatgacatt tgcctatgtc tgctatcggc   1020
 agtattatcc tcctctgact gatgcagaat gccataaacc atttcaagac aaacttgtac   1080
 tttccactgc acagaagcct ggggattctt attgttttga tatttaaaaa ttgaatctgg   1140
 ccgggcgtgg tggctcatgc ctgtaatccc aacactttgg gaggctgagg agggtggatc   1200
 acctgaggtc aggaccagcc tggccaacat ggggaaccct gtctctacta aaaatacaaa   1260
 aattagccag gagttgtgtg ccgtaatccc agctacctgg gaggctgagg taggagaatt   1320
 gcttgaacct gggagctgga ggttccagtg agccgagatc gcaccactgc actccagcct   1380
 aggcaacaga gtgagacccc gtct                                          1404



      <210> 1917
      <211> 460
      <212> DNA
      <213> Homo sapiens


      <400> 1917
 ccgaggatgg ccgtcatggc gccccgaacc ctcctcctgc tactctcggg ggccctggcc     60
 ctgacccaga cctgggcggg ctcccactcc atgaggtatt tcttcacatc cgtgtcccgg    120
 cccggccgcg gggagccccg cttcatcgcc gtgggctacg tggacgacac gcagttcgtg    180
 cggttcgaca gcgacgccgc gagccaaaaa atggagccgc gggcgccgtg gatagagcag    240
 gaggggccgg agtattggga ccaggagaca cggaatatga aggcccactc acagactgac    300
 cgagcgaacc tggggaccct gcgcggctac tacaaccaga gcgaggacgg tgagtgaccc    360
 cggcccgggg cgcaggtcac gacccctcat cccccacgga cgggccaggt cgcccacagt    420
 ctccgggtcc gagatccacc ccgaagccgc gggaccccga                          460



      <210> 1918
      <211> 2081
      <212> DNA
      <213> Homo sapiens


      <400> 1918
 tttcttgtag ctcactcgag cctccaccta ccaggttcaa gccattctca tgtctcattc     60
 ttttaagtgg ctgggattac aggtgcacgc cacagtgccc agctaatttt tatattttta    120
 gtagagacag ggtttcacca tgttggccag gctgttctca aactcctggc ctcaagtgat    180
 ccgcccacct cggcctccca aagtgctggg attacaggtg ttagccacca tgcctggctg    240
 ctaattttta attttttgta gagacagggt ctccctgtgt tgcccagact gttctcaaac    300
 tcctgggctc aagcaatcct cccacctcag cctcccaaag tgctggaatt acagtcatga    360
 gccatcatgc ccagccagga tatggacttc ttgactagta ggaagaaagt gggctggaca    420
 cactggctca cacttgtgat cccagcactt tgggagaccg aggtgggagg agatcttgag    480
 gcccagagtt tgagaccggc ttgtgcaaca tagtgatgta gcaggacgag ccacagacaa    540
 aacctctcag acactgagtt gtagaaggaa gggctttatt cagctgggag catcggcaaa    600
 ctactgcctt aaaatccgag ctccccaaat gcacaatttc tgtccctttt aagggctcac    660
 aacactaaag atttcacatg aaagggtcgt gattgatttg agcaagcagg cggtacatga    720
 caggggctgc atgcaccagt ggtcagagag aaacagaaca gggcagggag tttcacaatg    780
 ttcttctata caatgtctgg aatctatgaa taacatcagt ttctaagtta tgagttgatt    840
 tttaactact gggtttaggc cagacaggcc caggcctgct ttcaggcctg gtgccgggct    900
 gcctgtcttt ggttttactt ccttgtcact ttttcttaaa agaggtactg agtataaaac    960
 aatataaaac aatataaaac aatatgagag ggtctctctc tcttccctca tttcccccct   1020
 ttgagactct cagtttttat tagtgggagt tctcactctt atttttgcta cttatgtatt   1080
 ttcgtgcaat agattgatag tgatttatat agtatgcttg tgctgaagca ttttggtgaa   1140
 ctaaggttaa gcgacgaagt tttttatcat ttggagaaat acaggtatca gacaagggag   1200
 cagtaagcag gttcctatta ctattattac tcttattata agagttttaa atccacctat   1260
 tgctgggaac caatttccaa acatggctcc cagattgagt ccgtgccaca cttgcacagg   1320
 tgcatgtgcc agttttgtta tatctttaac tatatcctca actacttgcc cctgatcatc   1380
 tatgtgtaga caataattag taaggtcaaa tttttcacaa actcctcctt cagctgctag   1440
 caagtaatca agagctagtc tattttgata gatagcattt ctcatcagag tctcttgcca   1500
 ggcaagaaca gtcaaggctt gagtggtttt attagtaata atttctaaaa ctgcttgtaa   1560
 ccatatgatt cggttgagca tgtagatggg ggttccatat ccccatgaga catcttgtga   1620
 ccaagtggca ggtccatagt attgtaagat tttttcaggg ggccattcat cgtctttcca   1680
 atcacctatg gctatgcttc atttttcaca ggaagcacag actgggaagc ccagaagttt   1740
 acctgttttt atgggcacta agaagaaaga tggcttaatg gtgccaatta cacagctacc   1800
 tgtccactga tcaggcagct tagcataagc tctgtgtcca catacccagt ataacccagt   1860
 gggggccgtc cagtcccagt gcaattctgg gtgggcccaa acagtctgca actttggaaa   1920
 tttactgaat ggattttttt ctgtgtaatt ggaactccac catgtaactg tttttgtggt   1980
 accattatac agcttttgcc caagacaact aagctgccct acaggatgag taaatccttt   2040
 tccttctcta gctatgcaat actgtccaat aataagactt t                       2081



      <210> 1919
      <211> 919
      <212> DNA
      <213> Homo sapiens


      <400> 1919
 ggaacatgga gcgggggccg gtggtggggg caggactggg ggccggggcc cgtatccagg     60
 cactgctggg ctgcctgctc aaggtgctgc tctgggtggc ctctgccttg ctgtactttg    120
 gaagcgaaca ggccgcccgc cttctgggca gcccctgctt acggcgcctc taccatgcct    180
 ggctggcagc agtggtcatc tttgggccgc ttctgcagtt ccatgtcaac cctcggacta    240
 tcttcgccag ccacggcaac ttcttcaaca taaaatttgt gaattcagcc tggggctgga    300
 catgcacttt cttagggggc tttgtgttgc tggtggtgtt cctggctaca cggcgcgtgg    360
 cagtaactgc cagacacctg agccgactgg tagtaggggc agccgtgtgg cggggagccg    420
 gccgggcctt cctgctcatc gaggacctga ctggctcctg cttcgagcca ctgccccagg    480
 gtctgctgct ccacgagctg cctgaccgcc gcagctgcct ggcagccggc caccagtggc    540
 gaggctacac cgtctcctcc cacaccttcc tgctcacctt ttgctgcctg ctcatggcag    600
 aggaagcagc tgtgttcgcc aagtacctgg cccatgggct tcctgccggc gccccactgc    660
 gccttgtctt cctgctgaac gtgctgctgc tgggcctctg gaacttcttg ctgctctgta    720
 ccgtcatcta tttccaccag tacactcaca aggtggtggg cgccgcagtg ggcacctttg    780
 cctggtacct cacctatggc agctggtatc atcagccctg gtctccaggg agcccaggcc    840
 atgggctctt cccccgtccc cactccagcc gcaagcataa ctgaaagaaa taaaaaccat    900
 cgggcctgaa aaaaaaaaa                                                 919



      <210> 1920
      <211> 1164
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> misc_feature
      <222> (1)...(1164)
      <223> n = a,t,c or g


      <400> 1920
 ctccagagcg gtggaattcg tggagaaggg tgagaagact ggaaagacaa cctgaatggg     60
 ggactgggag ccttgaataa caggcatgga gaggagcgtc tcttgaaatg gaagaaacag    120
 gaaataatta cagcctctat ggaggagcaa caggatggac tggagaaact atcattccaa    180
 aatccagttg gggcctcaaa ggcccttaga atttttctag gaaggttgaa ggccagctgc    240
 tgacccagga ctcacatgtg cttcgtcctc ttccctagga atgatgacag gcacaataga    300
 aacaacgggg aacatttctg cagagaaagg tggctctatc atcttacaat gtcacctctc    360
 ctccaccacg gcacaagtga cccaggtcaa ctgggagcag caggaccagc ttctggccat    420
 ttgtaatgct gacttggggt ggcacatctc cccatccttc aaggatcgag tggccccagg    480
 tcccggcctg ggcctcaccc tccagtcgct gaccgtgaac gatacagggg agtacttctg    540
 catctatcac acctaccctg atgggacgta cactgggaga atcttcctgg aggtcctaga    600
 aagctcagtg gctgagcacg gtgccaggtt ccagattcca ttgcttggag ccatggccgc    660
 gacgctggtg gtcatctgca cagcagtcat cgtggtggtc gcgttgacta gaaagaagaa    720
 agccctcaga atccattctg tggaaggtga cctcaggaga aaatcagctg gacaggagga    780
 atggagcccc agtgctccct cacccccagg aagctgtgtc caggcagaag ctgcacctgc    840
 tgggctctgt ggagagcagc ggggagagga ctgtgccgag ctgcatgact acttcaatgt    900
 cctgagttac agaagcctgg gtaactgcag cttcttcaca gagactggtt agcaaccaga    960
 ggcatcttct ggaagataca cttttgtctt tgctattata gatgaatata taagcagctg   1020
 tactctccat cagtgctgcn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nncaantgag   1080
 tgaataaatg tcatcctctt ctccatcttc nnnnnnnnnn nnnggggggg cccttttaag   1140
 agaacacacc ttcacgcccg cccg                                          1164



      <210> 1921
      <211> 669
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> misc_feature
      <222> (1)...(669)
      <223> n = a,t,c or g


      <400> 1921
 gattacgcca agcttggcac gaggggcagc gcctggcccg ggcgcgcaaa gctgctcttc     60
 tcgcactcgg ggctctggcg catctgcgaa gtgctgcacc gtgcagtcat tgtggtcctg    120
 cccctgagcc tggtccttct cgtgtgtggc tggatctgcg gcctgctcag ctccctggcc    180
 cagagcgtgt ctctgctgct tttcaccggc tgctacttcc tgctggggag tgtcctgaca    240
 ctggcggggg tcagcatcta catcagctac tcgcacctgg cctttgcgga gacggtgcag    300
 cagtatggcc cgcagcacat gcagggcgtc cgcgtcagct tcggctgggc catgggcctg    360
 gcctggggct cctgtgcctt ggaggcattc agcggaaccc tcctgctctc agctgcctgg    420
 accctcagcc tgagcccccc aatctgtggt catctgagtc cccagcaggt gggagggaga    480
 gggggagact gaggcccaga gcggcagagg gacccaccca gatcgcctgg cgccagagag    540
 atgccgtctc aggccaaggc ctccctggcc tctgttctgt ccactctccc cgaagggcag    600
 gcttggtgga gaagaggctg atgagagggc ccgagagccc cttcgatttg cannnnnnnn    660
 nnncaaggg                                                            669



      <210> 1922
      <211> 442
      <212> DNA
      <213> Homo sapiens


      <400> 1922
 accgtaccgg ccggaattcc cgggatcagc tgctggggtt gccaccattc tcaggaccct     60
 cgccatgaaa gcccttatgc tgctcaccct gtctgttctg ctgtgctggg tctcagctga    120
 cattcgctgt cactcctgct acaaggtccc tgtgctgggc tgtgtggacc ggcagtcctg    180
 ccgcctggag ccaggacagc aatgcctgac aacacatgca taccttggta agatgtgggt    240
 tttctccaat ctgcgctgtg gcacaccaga agagccctgt caggaggcct tcaaccaaac    300
 caaccgcaag ctgggtctga catataacac cacctgctgc aacaaggaca actgcaacag    360
 cgcaggaccc cggcccactc cagccctggg ccttgtcttc cttacctcct tggctggcct    420
 tggcctctgg ctgctgcact ga                                             442



      <210> 1923
      <211> 2928
      <212> DNA
      <213> Homo sapiens


      <400> 1923
 atggggctgg cactggatct ggactccgga ctgctgggta ccctcatgcc tctctgcctg     60
 agatgccaca ggacccagac caaacatgcc gctgcatgcc agggccagca tcctagggtc    120
 caggctgagg atgtcacctt cctctaccac ccctgtgccc atccctggct gaagctccag    180
 cttgccctcc tggcctatgc ttgtatggct aacccttccc tcacccctga cttcagcctc    240
 acgcaggatc gggcactggc tctgagcttt gctctgcgga gctggcggtc tccctggcac    300
 agagaggtag aaggccagcc ggtcagtgag ctcatattgg cactcaacca gcctttccgc    360
 cagctcatgg tgccccgcct gcctgtgagg agggggtatg gctcagacct gcagcagcag    420
 ccctcaccca cacccccacc cacccacact gcacccttca gccgaccctc acctggcata    480
 gtcaatgggt gtgcggccat taacatcagg ggagccaggt ctaaagaact ccaaataaaa    540
 aagcagtttc aggatacctg caaaatccaa accagacagt acaaagcatt aagaaatcac    600
 ctgctggaga ctacaccaaa gagtgagcac aaagctgttc tgaaacggct caaggaggaa    660
 cagacccgga aattagctat cttggctgag cagtatgatc acagcattaa tgaaatgctc    720
 tccacacaag ccgcctcctt ggagctgcta ggtgtcccag gggcagccag ggtgcagctt    780
 gtgggtgggg aggtgcgctc acgcaatgcg tattcactgc acactctgct cctcttagca    840
 actacactcg agcgtgcgga caggcaacct ggagacatgt ctgcgcctgc tctccctggg    900
 ttcttcgcta gccaacacaa cagcctagag gatccccctc cacatcaagg aaatcctcag    960
 ccctgggagt ggcttcccca gaaacagcag ccccaagcct ccgagagtca gtcggagaaa   1020
 aggacacact caggcgccct ggacagggat gcccgtccga cctacaagga acgcctcgta   1080
 aaccggggtc acaccgacaa atctgaagcg ggtttgccag gggagtgtac ccgtcttccc   1140
 cagcctgtgc cacccggttc acaaggattt caatttccga ccttaaaatt cgctccaacg   1200
 atctcatcca aacgctgcaa acagcggcat aacaaactat ggagatctca ttcagatagt   1260
 gacctctcag accaccacga acccatctgc aaacctgggc tagaactcaa caagaaggat   1320
 atcaccacct cagcagacca gattgctgag gtgaagacca tggagagtca cccacccata   1380
 cctcctgtct ttgtggaaca tatggtccca caagatgcaa atcagaaagg cctgtgtacc   1440
 aaagaaagaa tgatctgctt ggagtttact tctagggaat ttcatgctgg acagattgag   1500
 gatgaattaa acttaaatga catcaatgga tgctcatcag ggtcgactct agaggatccc   1560
 cagtttaatg atgacagccc ggaagcgagg aaaataaccc ggcgctggag aataggtgaa   1620
 gcagcggatt tagttggggt ttcttctcag gctatcagag atgccgagaa agcagggcga   1680
 ctaccgcacc cggatatgga aattcgagga cgggttgagc aacgtgttgg ttatacaatt   1740
 gaacaaatta atcatatgcg tgatgtgttt ggtacgcgat tgcgacgtgc tgaagacgta   1800
 tttccaccgg tgatcggggt tgctgcccat aaaggtggcg tttacaaaac ctcagtttct   1860
 gttcatcttg ctcaggatct ggctctgaag gggctacgtg ttttgctcgt ggaaggtaac   1920
 gacccccagg gaacagcctc aatgtatcac ggatgggtac cagatcttca tattcatgca   1980
 gaagacactc tcctgccttt ctatcttggg gaaaaggacg atgtcactta tgcaataaag   2040
 cccacttgct ggccggggct tgacattatt ccttcctgtc tggctctgca ccgtattgaa   2100
 actgagttaa tgggcaaatt tgatgaaggt aaactgccca ccgatccaca cctgatgctc   2160
 cgactggcca ttgaaactgt tgctcatgac tatgatgtca tagttattga cagcgcgcct   2220
 aacctggagg atccccgcgt aggagtaatg gctcgcggta atgccattac tttgcctgta   2280
 tgtggtcggg atgtgaagtt tactcttgaa gtgctccggg gtgatagtgt tgagaagacc   2340
 tctcgggtat ggtcaggtaa tgaacgtgac caggagctgc ttactgagga cgcactggat   2400
 gatctcatcc cttcttttct actgactggt caacagacac cggcgttcgg tcgaagagta   2460
 tctggtgtca tagaaattgc cgatgggagt cgccgtcgta aagctgctgc acttaccgaa   2520
 agtgattatc gtgttctggt tggcgagctg gatgatgagc agatggctgc attatccaga   2580
 ttgggtaacg attatcgccc aacaagtgct tatgaacgtg gtcagcgtta tgcaagccga   2640
 ttgcagaatg aatttgctgg aaatatttct gcgctggctg atgcggaaaa tatttcacgt   2700
 aagattatta cccgctgtat caacaccgcc aaattgccta aatcagttgt tgctcttttt   2760
 tctcaccccg gtgaactatc tgcccggtca ggtgatgcac ttcaaaaagc ctttacagat   2820
 aaagaggaat tacttaagca gcaggcatct aaccttcatg agcagaaaaa agctggggtg   2880
 atatttgaag ctgaagaagt tatcactctt ttaacttctg tgctttaa                2928



      <210> 1924
      <211> 740
      <212> DNA
      <213> Homo sapiens


      <400> 1924
 ggaattcccc cctcaggtcc cagccttctc ccaagagatg ggagtgcctt tccattccgg     60
 taaagattcc aggcttctca ggaacgggca cgcaaagaat aagatgggtt gatgggttgc    120
 aagcatcctg gctcactctc accctatgct aaactcaggc gaccgtgctg tgtgacatca    180
 tagtcctcta ctgcatgaag aaaagactct actatcggga gaagaaatat aaatatgtgg    240
 aagattacga gcaggtaggc ccctcctggc ccccagcagg cacaggcctc tcatctcttg    300
 ggtgtgggag ccctgggcgt gggcctgtct ggggaggccc ttctgcagag gctggcacca    360
 gtgtggcgtg gtgtccccgt taacccgggc agtcctgcca ctctcagcag ctgctccatc    420
 cctaggcccc tgtactagat tgactcttta aacccagcct cgtttcaatg agcgacatct    480
 caggttggtg atgataatgc atgctctgag aatgcctgtg ggcacacact acttcagtgc    540
 accttgcgga acaggaaggg ttgggttcca ggcctgggac caacttgaga acccctggcg    600
 gtgaagtccc aggagcgcac ctccctcccg cctgccacaa ggggtcccag gggcaccttg    660
 atctgcttgt gtccttcttt gcagggtctt gctagtgagc tggaccagtg aggcctaccc    720
 cacacctggg ctctccacag                                                740



      <210> 1925
      <211> 414
      <212> DNA
      <213> Homo sapiens


      <400> 1925
 atggagacag cggctcctgt aaacagcaga tagaaagcca ggcttttgaa ctggccctgg     60
 aggaaggtct cagtgcccac gccgatcaac actgcagcag tggtgatgcc caggagccgg    120
 caggtgtatt ccagcccagt ccagaacacc tggagctgca tggtgccagg ggtgaggaca    180
 aagtcctggc agggcaggca gcaaagtctt cggccctgag atgctcccga acacccttgt    240
 gtaggtagga ggctgctggc tgtggctgca caccggggcc ctgccttccc aaaccagtcc    300
 tggccaccgc agcctggccg aggtgtgaat agggctcacc ttctgtgctc tcagcccgtg    360
 cccttgccag gcactcagct taatcattac cttggaagaa tgctcctgac gaaa          414



      <210> 1926
      <211> 1234
      <212> DNA
      <213> Homo sapiens


      <400> 1926
 atgaatttgg gaaccgattt gatgtcaaca actgctccat ctgctaccac tgggtcacct     60
 ccaggccgca ggagcctgca gtcttctcgg ccgattacag aggctgccac gtgctggaga    120
 aggatgggcg tttccacctg agggtgttca tggaggctgt gctgcccaat ggtcgtgtgg    180
 atgtggcaca agacgctact ctgatctgtc ccaaacctga cccctcccgg actctggact    240
 cccagctggc accacccgcc atgttctctg tctcaatccc acaaaccctt tccttcctcc    300
 ccacctctgg ccatacctcc caaggctctg gccatgcctt tcccagccca ctggacccag    360
 ggcacagctc tgtccaccca acccctgctt taccatcccc tggacctgga cctaccctcg    420
 ccaccctggc tcaaccccac tggggcacct tggaacactg ggatgtgaac aaacgagatt    480
 acataggtac ccacctgagc caggagcagt gccaggtggc ctcagggcac ctcccctgca    540
 tcgtgagaag aacttcaaaa gaagcctgtc agcaggctgg ctgctgctat gacaacacca    600
 gagaggttcc ctgttactat ggcaacacag ctactgtcca gtgcttcaga gatggctact    660
 tcgtcctcgt ggtgtcccaa gaaatggcct tgacacacag gatcacactg gccaacatcc    720
 acctggccta tgcccccacc agctgctccc caacacagca cacggaagct ttcgtggtct    780
 tctacttccc tctcacccac tgtggaacca caatgcaggt ggctggcgac cagctcatct    840
 atgagaactg gctggtgtct ggcatccaca tccaaaaggg gccacagggt tccatcacgc    900
 gggacagcac cttccagctt catgtgcgct gtgtcttcaa cgccagtggc ttcctgccca    960
 ttcaggcatc cattttccca cccccatcgc ctgctcctat gacccagccc ggccccctgc   1020
 ggcttgagct gcggattgcc aaagacgaga ccttcagctc gtactatggg gaggatgact   1080
 atcccatcgt gaggctgctc cgagaaccag tccatgtgga ggtccggctt ctgcagagga   1140
 cagaccccaa cctggtcctg ctgctgcacc agtgctgggg cgctcccagt gccaacccct   1200
 tccagcagcc ccagtggccc atcctgtcag acgg                               1234



      <210> 1927
      <211> 417
      <212> DNA
      <213> Homo sapiens


      <400> 1927
 aggaattagg gggtcgagcc acgcgtccgg ctacgtccgc tgggagggcg ttttccgctg     60
 catccccatc ttcggcatgt ccttggcctg gcggtcccag gtgctgccca cctacgacag    120
 cctggatgag ccgtcagtga aaaccatgag ctccatattt gcttcctccc ttaatgtggt    180
 caccaccttc tacgtcatgg gggggttttt cggctacgtc agcttcaccg aggccacggc    240
 cggcaacgtg ctcatgcact ttccctccaa cctggtgacg gagatgctcc gtgtgggctt    300
 catgatgtca gtggctgtgg gcttccccat gatgatcctg ccatgcaggc aggccctgag    360
 cacgctgctg tgtgagcagc agcaaaaaga tggcaccttt gcagcagggg gctacat       417



      <210> 1928
      <211> 1253
      <212> DNA
      <213> Homo sapiens


      <400> 1928
 cccacgcgtc cggcttctcc gcccgagccg ttcgcggagc tgccgggggc tccttagcac     60
 ccgggcgccg gggccctcgc ccttccgcag ccttcactcc agccctctgc tcccgcacgc    120
 catgaagtcg ccgttctacc gctgccagaa caccacctct gtggaaaaag gcaactcggc    180
 ggtgatgggc ggggtgctct tcagcaccgg cctcctgggc aacctgctgg ccctggggct    240
 gctggcgcgc tcggggctgg ggtggtgctc gcggcgtcca ctgcgcccgc tgccctcggt    300
 cttctacatg ctggtgtgtg gcctgacggt caccgacttg ctgggcaagt gcctcctaag    360
 cccggtggtg ctggctgcct acgctcagaa ccggagtctg cgggtgcttg cgcccgcatt    420
 ggacaactcg ttgtgccaag ccttcgcctt cttcatgtcc ttctttgggc tctcctcgac    480
 actgcaactc ctggccatgg cactggagtg ctggctctcc ctagggcacc ctttcttcta    540
 ccgacggcac atcaccctgc gcctgggcgc actggtggcc ccggtggtga gcgccttctc    600
 cctggctttc tgcgcgctac ctttcatggg cttcgggaag ttcgtgcagt actgccccgg    660
 cacctggtgc tttatccaga tggtccacga ggagggctcg ctgtcggtgc tggggtactc    720
 tgtgctctac tccagcctca tggcgctgct ggtcctcgcc accgtgctgt gcaacctcgg    780
 cgccatgcgc aacctctatg cgatgcaccg gcggctgcag cggcacccgc gctcctgcac    840
 cagggactgt gccgagccgc gcgcggacgg gagggaagcg tcccctcagc ccctggagga    900
 gctggatcac ctcctgctgc tggcgctgat gaccgtgctc ttcactatgt gttctctgcc    960
 cgtaatttat cgcgcttact atggagcatt taaggatgtc aaggagaaaa acaggacctc   1020
 tgaagaagca gaagacctcc gagccttgcg atttctatct gtgatttcaa ttgtggaccc   1080
 ttggattttt atcattttca gatctccagt atttcggata ttttttcaca agattttcat   1140
 tagacctctt aggtacagga gccggtgcag caattccact aacatggaat ccagtctgtg   1200
 acagtgtttt tcactctgtg gtaagctgag gaatatgtca cattttcagc ggc          1253



      <210> 1929
      <211> 1214
      <212> DNA
      <213> Homo sapiens


      <400> 1929
 gtgcagtgag gcggaataca caagcgcagc caccgaggcc ggcctggagc tggtggacaa     60
 gggcaaggcc aaggagctgc cagggagtca agtgattttt gaaggcccca ctctggggca    120
 gcaggaagac caagagcgga agaggttgtg taaggccatg accctgtgca tctgctacgc    180
 ggccagcatc gggggcaccg ccaccctgac cgggacggga cccaacgtgg tgctcctggg    240
 ccagatgaac gagttgtttc ctgacagcaa ggacctcgtg aactttgctt cctggtttgc    300
 atttgccttt cccaacatgc tggtgatgct gctgttcgcc tggctgtggc tccagtttgt    360
 ttacatgaga ttcaatttta aaaagtcctg gggctgcggg ctatagagca agaaaaacga    420
 gaaggctgcc ctcaaggtgc tgcaggagga gtaccggaag ctggggccct tgtccttcgc    480
 ggagatcaac gtgctgatct gcttcttcct gctggtcatc ctgtggttct cccgagaccc    540
 cggcttcatg cccggctggc tgactgttgc ctgggtggag ggtgagacaa agtatgtctc    600
 cgatgccact gtggccatct ttgtggccac cctgctattc attgtgcctt cacagaagcc    660
 caagtttaac ttccgcagcc agactgagga agaaaggaaa actccatttt atccccctcc    720
 cctgctggat tggaaggtaa cccaggagaa agtgccctgg ggcatcgtgc tgctactagg    780
 gggcggattt gctctggcta aaggatccga ggcctcgggg ctgtccgtgt ggatggggaa    840
 gcagatggag cccttgcacg cagtgccccc ggcagccatc accttgatct tgtccttgct    900
 cgttgccgtg ttcactgagt gcacaagcaa cgtggccacc accaccttgt tcctgcccat    960
 ctttgcctcc atgtctcgct ccatcggcct caatccgctg tacatcatgc tgccctgtac   1020
 cctgagtgcc tcctttgcct tcatgttgcc tgtggccacc cctccaaatg ccatcgtgtt   1080
 cacctatggg cacctcaagg ttgctgacat ggtaacacag ctgtttttat ttactcccgt   1140
 cggactataa cgctgttgtc ataagggatg ccccatttat gaatgacaga gtttcaaaac   1200
 gatgtcatgt gact                                                     1214



      <210> 1930
      <211> 2624
      <212> DNA
      <213> Homo sapiens


      <400> 1930
 cgcctctccc aaagtctagc cgggcagggg aacgcggtgc attcctgacc ggcacctggc     60
 gaggctcatg cgtcccgtga gggcggttcc tcgagcctgg gggcgctcag attgctttgg    120
 agacgctgag agaacctttg cgagagcgcc ggttgacgtg cggagtgcgg ggctccgggg    180
 gactgagcag cacgagaccc catcctcccc tccgggtttt cacactgggc gaagggagga    240
 ctcctgagct ctgcctcttc cagtaacatt gaggattact gtgttttgtg agagctcgct    300
 aggcgcccta agcaacagag ttctgagaaa tcgagaaaca tgataaggaa ttggctgact    360
 atttttatcc tttttcccct gaagctcgta gagaaatgtg agtcaagcgt cagcctcact    420
 gttcctcctg tcgtaaagct ggagaacggc agctcgacca acgtcagcct caccctgcgg    480
 ccaccattaa atgcaaccct ggtgatcact tttgaaatca catttcgttc caaaaatatt    540
 actatccttg agctccccga tgaagttgtg gtgcctcctg gagtgacaaa ctcctctttt    600
 caagtgacat ctcaaaatgt tggacaactt actgtttatc tacatggaaa tcactccaat    660
 cagaccggcc cgaggatacg ctttcttgtg atccgcagca gcgccattag catcataaac    720
 caggtgattg gctggatcta ctttgtggcc tggtccatct ccttctaccc tcaggtgatc    780
 atgaattgga ggcggaaaag tgtcattggt ctgagcttcg acttcgtggc tctgaacctg    840
 acgggcttcg tggcctacag tgtattcaac atcggcctcc tctgggtgcc ctacatcaag    900
 gagcagtttc tcctcaaata ccccaacgga gtgaaccccg tgaacagcaa cgacgtcttc    960
 ttcagcctgc acgcggttgt cctcacgctg atcatcatcg tgcagtgctg cctgtatgag   1020
 cgcggtggcc agcgcgtgtc ctggcctgcc atcggcttcc tggtgctcgc gtggctcttc   1080
 gcatttgtca ccatgatcgt ggctgcagtg ggagtgatca cgtggctgca gtttctcttc   1140
 tgcttctcct acatcaagct cgcagtcacg ctggtcaagt attttccaca ggcctacatg   1200
 aacttttact acaaaagcac tgagggctgg agcattggca acgtgctcct ggacttcacc   1260
 gggggcagct tcagcctcct gcagatgttc ctccagtcct acaacaacga ccagtggacg   1320
 ctgatcttcg gagacccaac caagtttgga ctcggggtct tctccatcgt cttcgacgtc   1380
 gtcttcttca tccagcactt ctgtttgtac agaaagagac cggggtatga ccagctgaac   1440
 tagcacccag ggacccagtg tacccagcct ctggcctcgt gccctgctgg ggaaggcctc   1500
 acccagcgaa ggccggagaa gcggttgggc cctggcacac agggctggct cagtgtgcgg   1560
 acagaggaga ccactctgct cctggggcca gaggccattc aatagcctgc cttcgtccgg   1620
 gcccctcctg ggcctccccg gccaggcacg tggcaccgtc gccttgacac cgccatctct   1680
 tttctttaag gcttcaggca gcgcgcacag gctctggcag ccgtctcagg caggactggg   1740
 cagcaagctt gcagccgaag gccttgcccc aaactaccag cgtttctgca agcagcttga   1800
 agggctgacc ttgcagccgg gtgagccaag ggcactttgc tgccaccgct gcattcccag   1860
 agatcaagca gcccggtgcc gtggccagtg aactcagagg tgctggtgga cgggctagga   1920
 ctttggggtt aggccatggg gctctttctc tgaaggccac tttcctgacg tactctctgt   1980
 acataactca gcgtccgtga ctgcagtaac agccagccct acccagagta tttctgagcc   2040
 atgaggggcc caccagattg gttctgaatt ggattcatgc ccagcgcatt agcatagtaa   2100
 ctcctttcag attttttgga gggacgtttg gaagtggctt actctcttct gccctctctc   2160
 ctacctccac cttctcagat gagccccatc tgagcacatc cagctgctcc ttacccagca   2220
 tctggagtac aggacatagc tctctcctgc taccagtctg tgccttagag gtctgttagg   2280
 cctgccaaac ggcgaccagc tcccctggag cgagggcagg ccccttccct ctctttcccc   2340
 agacacctac ttgagactca ccaatttctg gcctgttcag gagcctcaga taagtatttg   2400
 tacttgagac cacctcacac aatctgtatg gggcccaacc ctgatctcaa acctccttcc   2460
 ctctgcctga agctgtcgtc cttcctatgg caggaggggg gggggggtcc caggacgtgc   2520
 cctcatacat gacttgagct tggcagtccc ctgagtttcc ttttatgaga tcaacgcgag   2580
 gggcctggtt tttgaattaa agccccctcg cttcaaaaaa aaaa                    2624



      <210> 1931
      <211> 424
      <212> DNA
      <213> Homo sapiens


      <400> 1931
 ccctctgctc cgactcgccg gaccgacgcg atggcctcag aagtggtgtg cgggctcatc     60
 ttcaggctgc tgctgcccat ctgcctggca gtagcatgtg cattccgata caatgggctc    120
 tcctttgtct accttatcta cctcttgctc attcctctgt tctcagaacc aacaaaaacg    180
 acgatgcaag gacatacggg acggttatta aagtctctgt gcttcatcag tctttccttc    240
 ctgttgctgc acatcatttt ccacatcacg ttggtgagcc ttgaagctca acatcgtatt    300
 gcacctggct acaactgctc aacatgggaa aagacattcc ggcagatcgg ctttgaaagc    360
 ttaaagggag ctgatgctgg caatgggatc agagtgcttg tacccgacat cgggatggtc    420
 attg                                                                 424



      <210> 1932
      <211> 816
      <212> DNA
      <213> Homo sapiens


      <400> 1932
 tcatcaggaa cctcaattct cctgcactgc tggaagacag tgtgataaga caagcaaaag     60
 cagctggaaa aagaatagtc ttttatggag atgaaacctg ggttaaatta ttcccaaagc    120
 attttgtgga atatgatgga acaacctcat ttttcgtgtc agattacaca gaggtggata    180
 ataatgtcac gaggcatttg gataaagtat taaaaagagg agattgggac atattaatcc    240
 tccactacct ggggctggac cacattggcc acatttcagg gcccaacagc cccctgattg    300
 ggcagaagct gagcgagatg gacagcgtgc tgatgaagat ccacacctca ctgcagtcga    360
 aggagagaga gacgccttta cccaatttgc tggttctttg tggtgaccat ggcatgtctg    420
 aaacaggaag tcacggggcc tcctccaccg aggaggggaa tacacctctg attttaatca    480
 gttctgcgtt tgaaaggaaa cccggtgata tccgacatcc aaagcacgtc caacagacgg    540
 atgtggctgc gacactggcg atagcacttg gcttaccgat tccaaaagac agtgtaggga    600
 gcctcctatt cccagttgtg gaaggaagac caatgagaga gcagttgaga tttttacatt    660
 tgaatacagt gcagcttatt aaactgttgc aagagaatgt gccgtcatat gaaaaagatc    720
 ctgggtttga gcagtttaaa atgtcaaaaa gattgcatgg gaactggatc aaactgtact    780
 tggaggaaaa gcattcagaa gtcctattca acctgg                              816



      <210> 1933
      <211> 424
      <212> DNA
      <213> Homo sapiens


      <400> 1933
 agatcctgga gaaaagctgg gccccttcca tcccagatac cacccacagc tccaggtgga     60
 gagcagtgcc cactatatgc caaggaacca gccagttgct ggcgggagtg aacaagactt    120
 gagaaccctt cagagacagc ttcttgggct cactcctctc tctggagaca ctgttctcag    180
 cctcgcagga gtagttccca gcatcctgtt ctgacttcac tgggaagagg agggaggtgg    240
 ttccaccaca gggagctgag tggttcccca caatcttctc atcaaggtag aaggaataca    300
 ggatcggagg ggagcccctc tgtgcctcac agaggagctg caccatgtcc cccacagcag    360
 ggtcagcagg cccgtggtgc agagtgagca caggacggga tacaggagcc tgcactctga    420
 cctc                                                                 424



      <210> 1934
      <211> 1193
      <212> DNA
      <213> Homo sapiens


      <400> 1934
 cagagattcc ccgccgcgtt ccctggactc aggagctcgc cgcgatgccc cgccccactc     60
 tccacccgct gaatgcaggg cgcatgctgc tacttggcgg ctcaagcccc gcccgcaccg    120
 tccccattct ctgaccgccc ctctcccggt acactgcgca ggcacaacag agccgctccc    180
 ctctcctcgc cccgccaccg ggacggagag cgcccgccgc tgcatttccg gcgacacctc    240
 gcagtcattc ctgcggcttg cgcgcccttg tagacagccg gggccttcgt gagaccggtg    300
 caggcctggg gtagtctcct gtctggacag agaagagaaa aatgcaggac actggctcag    360
 tagtgccttt gcattggttt ggctttggct acgcagcact ggttgcttct ggtgggatca    420
 ttggctatgt aaaagcaggc agcgtgccgt ccctggctgc agggctgctc tttggcagtc    480
 tagccggcct gggtgcttac cagctgtctc aggatccaag gaacgtttgg gttttcctag    540
 ctacatctgg taccttggct ggcattatgg gaatgaggtt ctaccactct ggaaaattca    600
 tgcctgcagg tttaattgca ggtgccagtt tgctgatggt cgccaaagtt ggagttagta    660
 tgttcaacag accccattag cagaagtcat gttccagctt agactgatga agaattaaaa    720
 atctgcatct tccactattt tcaatatatt aagagaaata agtgcagcat ttttgcatct    780
 gacattttac ctaaaaaaaa agacaccaaa cttggcagag aggtggaaaa tcagtcatga    840
 ttacaaacct acagaggtgg cgagtatgta acacaagagc ttaataagac cctcatagag    900
 cttgattctt gtatattgat gttgtctttt ctttctgtat ctgtaggtaa atctcaaggg    960
 taaaatgtta ggtgtcagct ttcagggctc tgaaacccca ttccctgctc tgaggaacag   1020
 tgtgaaaaaa agtcttttag gagatttaca atatctgttc ttttgctcat cttagaccac   1080
 agactgactt tgaaattatg ttaagtgaaa tatcaatgaa aataaagttt actataaata   1140
 atatttccta tggggtcttc attgccagag ctgtctagtt catagaatga gat          1193



      <210> 1935
      <211> 1020
      <212> DNA
      <213> Homo sapiens


      <400> 1935
 atggggctgg gcccggtctt cctgcttctg gctggcatct tcccttttgc acctccggga     60
 gctgctgctg agccccacag tcttcgttat aacctcacgg tgctgtcctg ggatggatct    120
 gtgcagtcag ggtttcttgc tgaggtacat ctggatggtc agcccttcct gcgctatgac    180
 aggcagaaat gcagggcaaa gccccaggga cagtgggcag aagatgtcct gggaaataag    240
 acatgggaca gagagaccag ggacttgaca gggaacggaa aggacctcag gatgaccctg    300
 gctcatatca aggaccagaa agaaggcttg cattccctcc aggagattag ggtctgtgag    360
 atccatgaag acaacagcac caggagctcc cagcatttct actacgatgg ggagctcttc    420
 ctctcccaaa acctggagac tgaggaatgg acagtgcccc agtcctccag agctcagacc    480
 ttggccatga acgtcaggaa tttcttgaag gaagatgcca tgaagaccaa gacacactat    540
 cacgctatgc atgcagactg cctgcaggaa ctacggcgat atctagaatc cggcgtagtc    600
 ctgaggagaa cagtgccccc catggtgaat gtcacccgca gcgaggcctc agagggcaac    660
 atcaccgtga catgcagggc ttccagcttc tatccccgga atatcatact gacctggcgt    720
 caggatgggg tatctttgag ccacgacacc cagcagtggg gggatgtcct gcctgatggg    780
 aatggaacct accagacctg ggtggccacc aggatttgcc gaggagagga gcagaggttc    840
 acctgctaca tggaacacag cgggaatcac agcactcacc ctgtgccctc tgagctcgtg    900
 agcctgcagg tcctggatca acacccagtt gggacgagtg accacaggga tgccacacag    960
 ctcggatttc agcctctgat gtcagctctt gggtccactg gctccactga gggcacctag   1020



      <210> 1936
      <211> 462
      <212> DNA
      <213> Homo sapiens


      <400> 1936
 ggaattccag gaggctgcca agctgtacca caccaactat gtgcggaact cgcgggccat     60
 cggcgtgctg tgggccatct tcaccatctg ctttgccatc gtcaacgtgg tgtgcttcat    120
 ccagccctac tggataggcg acggcgtgga caccccgcaa gccggctatt tcgggctctt    180
 ccactactgc atcggcaacg gcttctcccg ggagctgacc tgcaggggca gcttcacgga    240
 cttctccacg ctgccctcgg gcgccttcaa agccgcctcc ttctttatcg gcctctccat    300
 gatgctcatc attgcctgca tcatttgctt taccctcttc ttcttctgca acacggccac    360
 tgtgtacaag atatgtgcct ggatgcagct cacctccgct gcctgccttg tgcttggctg    420
 tatgattttc cctgatggct gggactcaga tgaagtaaac cg                       462



      <210> 1937
      <211> 1333
      <212> DNA
      <213> Homo sapiens


      <400> 1937
 aagcttggca cgagggtctt gtcagcagcc cggccattgg agcatatctt tctgccagtt     60
 acggagacag cctcgttgtg ctggtggcca cagtggtggc tcttctggac atctgcttca    120
 tcttagtggc tgttccagaa tctctgcctg agaaaatgag accggtttcc tggggagctc    180
 agatttcttg gaaacaagca gacccttttg cgtcgttgaa gaaagttgga aaagattcta    240
 ctgtcttact aaatctgcat caccgtgtgt ctttcatacc ttcctgaagc tgggacagta    300
 ttcaagtttt ttttctctat ctcagggcag gtcatagggt ttgggatctg ttaaaattgc    360
 agcattcata gctatggtag gaattctgtc tattgtggct cagacggcct ttcttagcat    420
 cttgatgaga tcattaggaa ataagaatac tgtcctcctt ggcttgggct tccagatgct    480
 ccagttagcc tggtacggtt ttggatcaca ggcctggatg atgtgggcag cagggaccgt    540
 ggctgccatg tccagcatca cgtttccggc aatcagtgcc ctcgtctctc ggaatgcaga    600
 gtcagatcag caaggagttg cccaggggat cataactgga ataagaggac tatgcaatgg    660
 cctggggcca gcactgtatg gcttcatatt ctacatgttc catgtggaac tgactgagtt    720
 gggcccgaaa ttgaattcta acaacgttcc cctgcaggga gctgtcatcc caggcccgcc    780
 gtttttattt ggggcatgta tagtccttat gtcttttctg gctgccttat tcattcctga    840
 atacagtaaa gccagtggag ttcaaaaaca cagtaacagc agcagcggca gcctgaccaa    900
 caccccagaa cggggcagtg atgaggacat tgagccacta ctgcaagaca gcagcatctg    960
 ggagctctct tcatttgagg agcctgggaa tcagtgcact gagctgtaaa ctcggcagaa   1020
 agtgggattc tgcatacgcc atctctgaga gccatggagg gagccacacc cctggtgact   1080
 tcatggtgct ggatgggaga cgctagcggc atccttcagg gccaagtttg ataaatacca   1140
 ccgccatcat tctgctcatc ctcctcctgt tttttttttt ctcttacatt cttttttttt   1200
 tcccggttaa tccttaaaac cagaaaaaaa ttggaaaaac ttctttgcaa aaagggggca   1260
 actcccaggg ggaacctcaa ataaaaaaag cattcttttg tgaaaaaagg agggcttcct   1320
 tgaaaggaca aaa                                                      1333



      <210> 1938
      <211> 1333
      <212> DNA
      <213> Homo sapiens


      <400> 1938
 aagcttggca cgagggtctt gtcagcagcc cggccattgg agcatatctt tctgccagtt     60
 acggagacag cctcgttgtg ctggtggcca cagtggtggc tcttctggac atctgcttca    120
 tcttagtggc tgttccagaa tctctgcctg agaaaatgag accggtttcc tggggagctc    180
 agatttcttg gaaacaagca gacccttttg cgtcgttgaa gaaagttgga aaagattcta    240
 ctgtcttact aaatctgcat caccgtgtgt ctttcatacc ttcctgaagc tgggacagta    300
 ttcaagtttt ttttctctat ctcagggcag gtcatagggt ttgggatctg ttaaaattgc    360
 agcattcata gctatggtag gaattctgtc tattgtggct cagacggcct ttcttagcat    420
 cttgatgaga tcattaggaa ataagaatac tgtcctcctt ggcttgggct tccagatgct    480
 ccagttagcc tggtacggtt ttggatcaca ggcctggatg atgtgggcag cagggaccgt    540
 ggctgccatg tccagcatca cgtttccggc aatcagtgcc ctcgtctctc ggaatgcaga    600
 gtcagatcag caaggagttg cccaggggat cataactgga ataagaggac tatgcaatgg    660
 cctggggcca gcactgtatg gcttcatatt ctacatgttc catgtggaac tgactgagtt    720
 gggcccgaaa ttgaattcta acaacgttcc cctgcaggga gctgtcatcc caggcccgcc    780
 gtttttattt ggggcatgta tagtccttat gtcttttctg gctgccttat tcattcctga    840
 atacagtaaa gccagtggag ttcaaaaaca cagtaacagc agcagcggca gcctgaccaa    900
 caccccagaa cggggcagtg atgaggacat tgagccacta ctgcaagaca gcagcatctg    960
 ggagctctct tcatttgagg agcctgggaa tcagtgcact gagctgtaaa ctcggcagaa   1020
 agtgggattc tgcatacgcc atctctgaga gccatggagg gagccacacc cctggtgact   1080
 tcatggtgct ggatgggaga cgctagcggc atccttcagg gccaagtttg ataaatacca   1140
 ccgccatcat tctgctcatc ctcctcctgt tttttttttt ctcttacatt cttttttttt   1200
 tcccggttaa tccttaaaac cagaaaaaaa ttggaaaaac ttctttgcaa aaagggggca   1260
 actcccaggg ggaacctcaa ataaaaaaag cattcttttg tgaaaaaagg agggcttcct   1320
 tgaaaggaca aaa                                                      1333



      <210> 1939
      <211> 2166
      <212> DNA
      <213> Homo sapiens


      <400> 1939
 gaatttaaca cctcctaagg ttaatcggga aactgaaagt ttaaaaacaa cccagtggcc     60
 tcctgaagtt tggtaattta atattgaaat gccatccccc ttcccttacc catatgttaa    120
 gccaaccctg tgccagaagc ccctacccca gaccctaact gggaactggc ccctgtatat    180
 ccatccatcc tcaggaataa tgagtgccac tgtttccttt tggtccattg gaacagccct    240
 atttggaagc tcaaggaata tgggagccca tttcgaaggc ggctatccct ttgaggcctc    300
 gaacccgccc ttcgatgtgg gaaggccatt tgatctcagg agaatcgttg gtatttcatc    360
 tgaaggaaac ttgaacacac tcagctgtga ccccggtcac agtagggggt tctgtggagc    420
 aggcggatca tcatcccgac ccagtgccgg gagtcataag cagtgaggcc catcgggtca    480
 cccacacagc agccacagca atagaaactc agctgacgtg gatgacgtca gagcctataa    540
 cagtggacga acctctagca tgacttctgc tcaagcagct tcttcacagc ctgctaacaa    600
 aacacgcccc cttgtcttag attccaacac aggggctcaa ggtcattctg cgggcagaaa    660
 gtccaaaggg gcaaagcaga gccagcacgg cagccagcac catgcccaca gcccgctgga    720
 gcagcaccct cagcctcctc tgccaccgcc agtgcctcag ccccaggagc cgcagcctga    780
 aaggctgtct cccgcccccc tcgcacaccc ttcccaccca gaacgtgcca gcagcgcgag    840
 gcacagttcc gaggactcgg acatcaccag tctcatagaa gccatggaca aagacttcga    900
 ccaccatgac tccccagccc tagaagtgtt tacagagcag cctccatcgc cattgccaaa    960
 aagcaaaggt tcaactgaag gtggacctgc ttccacgttc acacaggcag ttgatggtgg   1020
 gattcagttc ttcacggact gttggacgga gggcccaagc tcctccttgc tggctgtggc   1080
 cagagaagta cagctggccc tgtgtatcca tgagcttctc atccatggat tcagtcaact   1140
 gcaggtttcg ggaggcccag gggcgatgcc agaccccgcg gcgcacctgc ccttcttcta   1200
 cggcagcatc tcgcgtgccg aggccgagga gcacctgaag ctggcgggca tggcggacgg   1260
 gctcttcctc gtgcgccagt gcctgcgctc gctgggcggc tatcgccagc tcaacggcac   1320
 ctacgccatt gccggcggca aagcgcactg tggaccggca gagctctgcg agttctactc   1380
 gcgcgacccc gacgggctgc cctgcaacct gcgcaagccg tgcataccgc cgtcgggcct   1440
 cgagccgcag ccggggtctt cgactgcctg cgagacgcca tgggcgaggc ctaggagcag   1500
 gccatcatca gccaggcccc gcaggtggag aagctcattg ctacgacgga ccacgagcgg   1560
 atgccctggt accacagcag cctgacgcgt gaggaggccg agcgcaaact ttactctggg   1620
 gcgcagaccg acggcaagtt cctgtatgtg gggcccggga tttgggtgcg ggattggatt   1680
 caaatcatgg aatcgtggac ccaccacatg gtcacagtgc agcctcagca gcgagtgaag   1740
 ctcgccagac ctcctccgga aagcagggcc agtgaaggtg tccagcactg gggctgcagg   1800
 gactccctgg ggtcttcctc taacctgagc tcgcctacaa gtggctcaag cctgccctgg   1860
 actcctcaca ggaatcacag cattctgctg atggagctca cggccctgac acagcccacc   1920
 atggagacgg tggccaggtg ccactccacc caggcaccac ttacctgggg acgtacaggt   1980
 ggatgtccag gcaaacaggc cacttgcggg gtctctggtc ccaatgccaa tggagagccg   2040
 gttctggtgg aattctactc cgcggtaagt ggaacagcat acggagacac gcagttccgc   2100
 acacgcatcg caaaggcctc aggctggatg aaagaaacca ggttccaagg gctacgaatt   2160
 gtgtga                                                              2166



      <210> 1940
      <211> 607
      <212> DNA
      <213> Homo sapiens


      <400> 1940
 cttcagcatg gaaagcccgt tacaatctgc ctgttcaggg attcaggctg gaacagctgg     60
 cgaggcctat gagcaggttt actgctggag tccttgggta ggctgccttg gtgactgatc    120
 agcggggact tgtgcctgat accttggtcc ataagacatg ggcctggttc tggggcagtc    180
 ctggagcctc catatgtgga aggcgttctg gagctgaggt gccataatct ttcacctggg    240
 ttccttagct cttgtgaagg tatcttcatg catggatggt agttcaaact gatgtttctt    300
 tgaaagactc tggccttgtc aaaagaagga cgtaagaagg cacgatgtat tatacttggg    360
 aatgatagaa gagactgacc tggtatttcc acccggaaga gggaaaggat tttaactaca    420
 aatacaggaa tccagcagat ggcatcagag aacactataa aaaagaaacg atttgcaaca    480
 gccacctctc ttccaaaaca attccttact tctgtgggct gcaaggcggg ttctttgaat    540
 ggaacacaac atactcctat tagaaacacc atgatgagaa aagccagccc gttcacacct    600
 agtggga                                                              607



      <210> 1941
      <211> 517
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> misc_feature
      <222> (1)...(517)
      <223> n = a,t,c or g


      <400> 1941
 tagttgaaac cataaggaca ctcgttgtat cagtcgtaca acacgctgac gtaacacata     60
 taccaaatgt ctaaaggccg gggnnnnnnn natttgaaac cttggttaga ccccctgaaa    120
 nccgcgncga cccacgcgnc cgggaggact gcagggccag nccccagggc caggcatgca    180
 ggggccccct cccatcacgc ccacctcctg gagcctgccc ccgtggaggg cctacgtggc    240
 tgccgccgtg ctctgctaca tcaacctcct gaattacatg aactggttca tcattgcagg    300
 agtgctgctg gatatacagg aggttttcca gatcagtgac aaccatgctg gtttgcttca    360
 aactgtcttc gttagctgcc tgctgctgtc tgcacctgtg tttggctacc tgggcgaccg    420
 acatagccgc aaggctacca tgagcttcgg tatcttgctg tggtcaggag ctggcctctc    480
 tagctccttc atctcccccc ggtattcttg gctcttt                             517



      <210> 1942
      <211> 1133
      <212> DNA
      <213> Homo sapiens


      <400> 1942
 ggcacgaggg ctccttggta ccatgtggga agcgctgtga agagttgttg ccttccaaga     60
 tatacccaaa ttcccagttc cagcccgtgt cattaaaact ccgctggcgt gaaagatgac    120
 gtccttagcc cagcagctgc aacgactcgc cctccctcaa agtgatgcca gcctcttatc    180
 cagagatgaa gttgcttctt tgttatttga ccctaaggaa gcggccacaa tcgacaggga    240
 caccgccttc gccattggat gtactggcct ggaagagttg cttggaattg atccttcctt    300
 tgagcagttt gaagcaccgt tgttcagtca gctagcaaaa accttggagc gaagtgttca    360
 gaccaaagca gtaaacaaac agttggatga aaacatttca ttattcctta ttcacttgtc    420
 gccttacttc ctgcttaagc cagcacagaa gtgtctggag tggttgattc acaggttcca    480
 tatacatctc tataatcaag atagcctcat tgcttgtgtt ctgccatacc acgagacaag    540
 aatatttgtg cgagtcatac agcttctaaa aattaataat tcaaagcaca gatggttctg    600
 gttgttgcca gttaagcaat ctggagtgcc gttagctaaa ggaactttga ttacccactg    660
 ctacaaagat cttggattca tggatttcat ttgcagtttg gtgacaaaat ctgtgaaggt    720
 ttttgctgag tacccgggca gctcagctca gttgagggtg ctcttggctt tctatgcttc    780
 taccatagtg tcggcgctgg tagctgcaga ggacgtatca gacaatatca tcgccaaact    840
 attttcctat atccaaaagg gattgaaatc atctttacca gattacagag ctgcaacata    900
 catgataata tgtcagattt ctgtgaaagt gaccatggaa aatacctttg tgaattcatt    960
 ggcatcacag atcatcaaaa cattgaccaa gattccctct ttgatcaagg atgggttaag   1020
 ttgcttgata gtgctcctgc agagacagaa gccagagagc cttgggaaaa agtatgtaca   1080
 attgaattga gaaatggtgc tagtcagagg tgaataaaat tattttgaat aaa          1133



      <210> 1943
      <211> 724
      <212> DNA
      <213> Homo sapiens


      <400> 1943
 gtggaggtgc cctcggctgt gcccaggcct actttggata ccagcagagc agctacctgt     60
 gccccagggc atgctgttca ccacccccag tccctcagct ggcccagaac tgctggcact    120
 gttggaggca gccctgcgct ccggggcgcc catccctgac ccctgcccac cgttcctgca    180
 gactgctgtg agccctgaga gcagtgccct ggccgccgtg gacagcagcg gctctgtgct    240
 ccttctcacc tcctcgctca actgctcctt tggctctgca cacctgtccc caagcactgg    300
 ggttctgctc agcaacctgg tggccaagtc taccactagt gcctgggcct gccccctcat    360
 cctccgtggc agcctggatg acacagaggc tgatgtgttg gggcttgtgg cttcagggac    420
 ccctgatgtg gccagggcca tgactcacac cctactcagg catctggcag caaggccccc    480
 tacccaggcc cagcaccagc atcagggtca gcaagaacca acagagcatc ccagcacttg    540
 tggccaaggg accctgctcc aggtggcagc ccacacagag cacgcccatg tctccagtgt    600
 cccccatgcc tgctgcccct tccaggggtt ctaacaggat gggggtgggt ctggcagaag    660
 gcagagttat ttgaagcatg ggggcaggag cagagcagac acagcagcaa tggagtgtgc    720
 accc                                                                 724



      <210> 1944
      <211> 5014
      <212> DNA
      <213> Homo sapiens


      <400> 1944
 tttcgtccaa cagccagctt tatagggcat cagccttgtt tgaaacaatc cgacatgagg     60
 cacagctgag cacggactac aaactctccc tctttgacct gcagacatca tcctaccagg    120
 ccttgcagcg ggtgctcgtc agcctaggcc atcatgatga agccctggct gtggcagaaa    180
 ggggacggac aagggcattt gctgatcttc tggtggaacg acaaacagga caacaagact    240
 ccgaccccta ctccccagtc actattgatc agatcttaga gatggtaaat ggccagaggg    300
 gactagtgct ttactattcc ctggctgcag gctatctgta tagctggctg ctggctcctg    360
 gggcaggaat tgtgaagttt catgaacact acctgggtga gaacacagtg gaaaactcaa    420
 gtgacttcca ggccagcagc agtgtaaccc ttccaacagc aaccggctca gccctggagc    480
 agcacattgc cagtgtccgg gaggccctgg gggtggagtc tcactactca agggcctgtg    540
 ccagcagtga gacagagagt gaagcgggag acatcatgga ccagcaattt gaagagatga    600
 acaacaaact caactcggtc actgacccca ctggctttct gcggatggtt cgccgcaata    660
 acctgtttaa caggagctgc cagagcatga cgagcctgtt cagtaacact gtgtcaccga    720
 cccaggacgg gacctcctct cttcccagga ggcagagctc gtttgccaag cccccgctcc    780
 gtgccctgta tgacctgctc atcgcgccca tggaaggggg cctgatgcac tccagcggcc    840
 ccgtgggccg gcaccggcag ctcatcctgg ttctggaggg ggagctctac ctcattcctt    900
 tcgccctcct gaagggaagc tcctccaatg agtacctcta cgagcgcttc ggcctccttg    960
 ctgtcccttc catccgctcc ctcagcgtgc agtccaagtc tcacttacgg aagaacccgc   1020
 ccacatactc cagctccaca tccatggcgg ctgtcatcgg caaccccaag ctaccatcgg   1080
 ccgtgatgga caggtggctg tgggggccca tgccatcggc cgaggaagag gcctacatgg   1140
 tgtccgagct gctgggctgc cagcccctag tgggcagtgt ggccaccaag gagagggtca   1200
 tgagtgccct gacccaggct gaatgcgtcc actttgccac ccacatctcc tggaagctgt   1260
 cggccttggt cctcacgccc agcatggacg gcaaccctgc cagcagcaag agctccttcg   1320
 gccaccccta cacgatccct gagtccttgc gggtgcagga cgatgccagt gatggggaga   1380
 gcatctcgga ctgcccgccc ctgcaggagc tgctgcttac tgccgccgac gtcctggacc   1440
 tgcagctgcc tgtgaagctg gtggtgcttg gctcctccca ggagtccaac agcaaagtcg   1500
 cagccgacgg ggtcatcgcg ctgacaaggg ccttcctggc tgccggcgct cagtgtgtcc   1560
 tcgtgtctct gtggcctgtg ccagtggctg cttttaagat gttcatccat gccttctact   1620
 catccctgct gaacggcctg aaagccagcg ccgccctggg ggaggccatg aaggtggtgc   1680
 agagcagcaa ggccttctcg cacccctcca actgggcagg gttcatgctc atcgggagtg   1740
 acgttaagct gaacagcccc tcatcactca tcggccaggc cctcacagag atcctgcagc   1800
 acccggagcg tgcgcgggac gccctgcgag tgctgctgca cctggtggag aaatccctgc   1860
 agcgcatcca gaatgggcag cgcaatgcca tgtacacatc ccagcagagt gtggagaaca   1920
 aagtgggcgg catccctggc tggcaggccc tcctcaccgc tgtgggcttc cggctggacc   1980
 ccccaaccag tggcctgcca gcggctgtct tcttcccaac ctccgacccg ggcgaccggc   2040
 tccagcagtg cagcagcaca ctccagtccc tgctgggtct gcccaatcct gccctccaag   2100
 ccctttgcaa actcatcact gcctccgaga cgggcgagca gctcatcagc cgggctgtta   2160
 aaaatatggt tggaatgctc caccaggtgc tggttcagct ccaggctggc gagaaggagc   2220
 aggacttggc atcagctccc attcaggtct ccatcagcgt ccagctgtgg cggctcccgg   2280
 gatgccacga gttcctggca gctctaggtt ttgatctctg tgaagttggt caggaggaag   2340
 taatcctgaa aaccgggaag caagctaatc gacggactgt gcacttcgcg ctccagtccc   2400
 tgctgtctct gtttgattct actgagctac ccaagcgcct cagccttgac agctcctcct   2460
 ccctcgagtc tcttgcttct gctcagtctg tttccaacgc cctgcccttg ggttaccagc   2520
 aacccccctt ctctcccacc ggtgcggaca gcatcgcctc agatgccatc tctgtgtaca   2580
 gtctgagctc cattgcctcc tcaatgagct ttgtctccaa acccgagggt ggatcagagg   2640
 gtggaggccc cggaggacgg caggaccatg accggtccaa gaacgcttac ctgcagagat   2700
 ccaccctgcc taggagccag ctgcctcccc agacccgccc tgcaggcaac aaagatgaag   2760
 aagaatatga agggttttct atcatcagta acgagccctt ggcgacctac caagaaaacc   2820
 gaaacacatg cttctcacca gaccacaaac aaccccaacc tgggacagcc ggaggcatga   2880
 gagtctcggt gagctccaaa gggagcatca gcactccaaa ttctccagtg aaaatgactc   2940
 tgattcccag ccccaactca cccttccaaa aggtgggaaa actagcaagc tcagatacag   3000
 gagaatcaga ccagtctagc acagaaacgg acagtaccgt gaaatcccaa gaagaaagca   3060
 acccaaaact ggatccacaa gagttagccc agaaaattct ggaggagaca cagagtcatc   3120
 tcattgcggt ggagcgtctt cagaggagcg gcggccaggt gagcaagagt aataaccctg   3180
 aagacggcgt tcaggcgccc agcagcactg ctgtcttcag agcgtcagaa accagtgcgt   3240
 tcagcaggcc tgttctctcc catcagaaga gtcagccatc accagtcact gttaaaccaa   3300
 agcccccagc caggagctcc tccctgccca aggtgagttc cggatatagc agccccacca   3360
 cctcagagat gtccatcaaa gacagcccga gccagcacag tggccggcca tcgcccggct   3420
 gcgactcaca gacttcccag ctggaccagc ctctctttaa actgaagtac cccagctctc   3480
 cttacagcgc tcacatttcc aaatcaccaa ggaacatgtc cccaagctcc ggccaccagt   3540
 ctcctgctgg cagtgcaccc tccccagctc tctcctactc ctcagctgga tctgctcgct   3600
 caagtccagc agacgctccc gacatagaca aactgaaaat ggcagccatt gatgaaaagg   3660
 tgcaggctgt ccataacctg aagatgttct ggcagagcac accccagcat tccacagggc   3720
 caatgaagat cttccggggg gctcctggca cgatgacttc caaaagggat gtcctcagtc   3780
 tgctgaattt gtcaccacgg cccaataaga aggaggaggg agtggataag cttgaactga   3840
 aggagctgtc cctgcagcag catgacggag ctccaccgaa agcccctccc aacggacact   3900
 ggcgcaccga gaccacctcg ctgggctcac tgccgctgcc cgccggccct cccgccacag   3960
 cccccgcgcg ccctttgagg cttccttctg gaaatggcta caagttcctg tctccaggaa   4020
 gatttttccc ttcttccaaa tgctaaagca tcttttatac ccactgactc tgagcagcct   4080
 gcagatgggg gcctggcgtt tgcttcagcc cttccctgag tgcagtcccc ccacagccac   4140
 cagcaccctc atgatgctgt gctctgcagg cgaggggcac caccacgtcc aaaggctgcc   4200
 acacacactg gtggcttttc tgggccacat tcaccaaaag ccaggacttc tgtggggctg   4260
 gtacaggagg ctcatggaat ttcctacaca cttcaccaaa tgtttgttta cctttgaact   4320
 ccctgcttct catctttgat atgattcttc accaggattt tgtacaaaaa tgatcatggt   4380
 tctggggtgg ggagaggaaa gggagcacat attttgctaa gaggtatata tgcagtacct   4440
 tttataccac agaaatacaa atagagcttt ttcctaaggc tttcggttgc ctggttgggg   4500
 gtgggatata tgaaatttca gttgaattct acaggaaagt gttatattag cccaaaaaca   4560
 gaaaaatggt ttttaaaatg ccaatgattt gtaattaaat tgtagcaatt ttggtctcat   4620
 gatagtgtaa tatctcagca acaatgcaat aattcacatt gaaacagcgc ttccattctg   4680
 aactcctgct ctgcaaatgt cttttgggtc ccgctgtcaa ccaaacttga attttcttaa   4740
 aaaaaaaatt atgtaactct tatccaggca ttttagaact atgcaattgt gatttaaaat   4800
 gcaactttgt gcttttaaaa cattattgac cttttttgta tatggataaa caacttggtt   4860
 ttattatcaa tagtactttg catttatagc tattattttt aaaagctcaa aaagtttttt   4920
 aaaatgtcaa attttgaata gtcatcaata agtaattatc aagtttggaa ggaaaggttg   4980
 aaatgactcc gtttccttat aagcaaaaaa aaaa                               5014



      <210> 1945
      <211> 888
      <212> DNA
      <213> Homo sapiens


      <400> 1945
 tcttacagac tggaacctac ctttggcttt tatgaaaaag aggctctgtg agaaaattga     60
 aggctccaaa tccttagctc agagctggag gatgaaggat cggatgaaca cagtcagtgt    120
 tgccttagtt ttgtgcctga atgttggtgt ggaccctccc gatgtggtga agaccacgcc    180
 ctgtgcacgc ttggaatgct ggatcgatcc tctgtcgatg ggtcctcaga aagctctggg    240
 aaccatcggt gcaaatttac agaagcagta cgagaactgg cagccaaggg cccggtacaa    300
 gcagagcctt gacccaactg tggatgaagt caagaagctc tgcacgtcct tacgtcgcaa    360
 cgccaaggag gagcgagtcc tctttcacta caatggccac ggggtgcccc ggcccacagt    420
 caacggggag gtctgggtct tcaacaagaa ctacacgcag tacatccctc tgtccatata    480
 tgacctgcag acgtggatgg gcagcccgtc gatcttcgtc tacgactgct ccaatgctgg    540
 cttgatcgtc aagtccttca agcagttcgc actacagcgg gagcaggagc tggaggtagc    600
 tgcaatcaac ccaaatcacc ctcttgctca gatgcctttg cctccgtcga tgaaaaactg    660
 catccagctg gcagcctgcg aggccaccga gctgctgccc atgatccccg acctcccggc    720
 tgacctattc acctcctgcc tcaccacccc catcaagatc gccctgcgct ggttttgcat    780
 gcagaaatgt gtcagtctgg tgcctggcgt cacactggat ttgatagaaa agtaagtagg    840
 atttttaagc tcttggggct ctctggatct gatgagtttc ttttcctt                 888



      <210> 1946
      <211> 1919
      <212> DNA
      <213> Homo sapiens


      <400> 1946
 tttttttttt ttaaaatatg aaccatttta ttgaagaaca gttatacagt gtagctacag     60
 atactgacta gatactaaat atttctgcct gatttttcat tgtcttcaca agttagggaa    120
 tagaaatcaa aaaaccaaaa atctcaaatg atttagctgt ccagaacata tttgacaggt    180
 ggataaattt ataacagctc tgacatataa atttctaatt agagaatcct ttcattttga    240
 aaaaattgag atgatattac cctaatgaag tttttacctg aagttaacaa agtcctggat    300
 ttgatatatt actttgaatg cattaattct gaaaatttat atttagttct actttataac    360
 atttcttctc ttaaggatgg gatatgaggt acacatgagc tggtttctac agtatgaatg    420
 tatgtacata tataaagtat ggttgtaaag gagtgggtga tttgcaaata aagcacatta    480
 tacacaaaat ataaataact tcccttttaa aagttactga gaataaagaa tatagaacat    540
 ggttataggc acttacattg ctatcaaatg caggaattca cttcaataag aagtgctttc    600
 tttgtaagca tggttcatgg caatagaagc tccaactttg gagaggatgc tttccgtgac    660
 aaaaataata accacaaaaa aaatggtggt tgaaggaaaa cagtccaaat ttacagatgc    720
 tttaaacttc ttttggcctt ggcatcagct ttcatgttaa aaaataaagc tggtggggaa    780
 gctatctcac ttgcaaagta aatggcttgt atgagattgg cgaatcttgg tcagatattg    840
 catttttaaa gcacaaaacc accggccacc aatatcttcc tgtgcatgca tataaattat    900
 tttcttctaa ttcaaatggc agcagaggaa tcccggcgtg catgtgcatg gagacacaca    960
 cacatcacta aggacacagg acaaactatc ataaaataag cagtatccca aacacatcat   1020
 catctatagg ctgttttaca aaggtagaat acaaacgaac tgaatgtctc aggtaaaagg   1080
 caaagtctat ttctccatct ctgctgcgct catttatctt cttaaggctt tcaacagaaa   1140
 gcaccgtttt atgaaacagg caattcagta cccagagctt gactggagac actaatcagg   1200
 attgaagtct tgatgcagtt cataaaaacc cacttaaaaa aaggcatcaa aaaccacatt   1260
 taaaataaag ctgtccatat ataaagaatg aagtgtttag aagttcccag cttgtatcct   1320
 aataagagta ctgaaaggtt taatattagc agcctgtgaa cacgtagtga agaaagagtc   1380
 tgagaaccaa gttaacatcc ttattccact ctaattccac ccatgccatg ggtaaaaaca   1440
 gttcttgcag tctagagttt ctcctccgat ggtttaacca tcagattttt acatcttggg   1500
 attcaaccat cttggcaagc gtcttcttaa ttctcaatgc tgtgagtctg gaggctggat   1560
 tgtgggccca gcattctgac attagcttca aaactgctcg tagacattca tcactgttcc   1620
 accgattaga cacaattggc cgcaaacgtt tgacacacac aacctcacgc atatcttcgt   1680
 atgacggatc actcggtacc atgttgtaat atggcaattg gtattcttcc ccgatcccta   1740
 taagggaatg agaaaacatg ggcacaaaaa tggttgctgg acaagatata ccaatctagt   1800
 aagcatcttt tgctaaacta tggaactaaa acggattctt acacaagaaa aaatatagac   1860
 cctatgattc cctcttaata gtagaagtat gtttttctct tatttatgtc caactattt    1919



      <210> 1947
      <211> 1919
      <212> DNA
      <213> Homo sapiens


      <400> 1947
 tttttttttt ttaaaatatg aaccatttta ttgaagaaca gttatacagt gtagctacag     60
 atactgacta gatactaaat atttctgcct gatttttcat tgtcttcaca agttagggaa    120
 tagaaatcaa aaaaccaaaa atctcaaatg atttagctgt ccagaacata tttgacaggt    180
 ggataaattt ataacagctc tgacatataa atttctaatt agagaatcct ttcattttga    240
 aaaaattgag atgatattac cctaatgaag tttttacctg aagttaacaa agtcctggat    300
 ttgatatatt actttgaatg cattaattct gaaaatttat atttagttct actttataac    360
 atttcttctc ttaaggatgg gatatgaggt acacatgagc tggtttctac agtatgaatg    420
 tatgtacata tataaagtat ggttgtaaag gagtgggtga tttgcaaata aagcacatta    480
 tacacaaaat ataaataact tcccttttaa aagttactga gaataaagaa tatagaacat    540
 ggttataggc acttacattg ctatcaaatg caggaattca cttcaataag aagtgctttc    600
 tttgtaagca tggttcatgg caatagaagc tccaactttg gagaggatgc tttccgtgac    660
 aaaaataata accacaaaaa aaatggtggt tgaaggaaaa cagtccaaat ttacagatgc    720
 tttaaacttc ttttggcctt ggcatcagct ttcatgttaa aaaataaagc tggtggggaa    780
 gctatctcac ttgcaaagta aatggcttgt atgagattgg cgaatcttgg tcagatattg    840
 catttttaaa gcacaaaacc accggccacc aatatcttcc tgtgcatgca tataaattat    900
 tttcttctaa ttcaaatggc agcagaggaa tcccggcgtg catgtgcatg gagacacaca    960
 cacatcacta aggacacagg acaaactatc ataaaataag cagtatccca aacacatcat   1020
 catctatagg ctgttttaca aaggtagaat acaaacgaac tgaatgtctc aggtaaaagg   1080
 caaagtctat ttctccatct ctgctgcgct catttatctt cttaaggctt tcaacagaaa   1140
 gcaccgtttt atgaaacagg caattcagta cccagagctt gactggagac actaatcagg   1200
 attgaagtct tgatgcagtt cataaaaacc cacttaaaaa aaggcatcaa aaaccacatt   1260
 taaaataaag ctgtccatat ataaagaatg aagtgtttag aagttcccag cttgtatcct   1320
 aataagagta ctgaaaggtt taatattagc agcctgtgaa cacgtagtga agaaagagtc   1380
 tgagaaccaa gttaacatcc ttattccact ctaattccac ccatgccatg ggtaaaaaca   1440
 gttcttgcag tctagagttt ctcctccgat ggtttaacca tcagattttt acatcttggg   1500
 attcaaccat cttggcaagc gtcttcttaa ttctcaatgc tgtgagtctg gaggctggat   1560
 tgtgggccca gcattctgac attagcttca aaactgctcg tagacattca tcactgttcc   1620
 accgattaga cacaattggc cgcaaacgtt tgacacacac aacctcacgc atatcttcgt   1680
 atgacggatc actcggtacc atgttgtaat atggcaattg gtattcttcc ccgatcccta   1740
 taagggaatg agaaaacatg ggcacaaaaa tggttgctgg acaagatata ccaatctagt   1800
 aagcatcttt tgctaaacta tggaactaaa acggattctt acacaagaaa aaatatagac   1860
 cctatgattc cctcttaata gtagaagtat gtttttctct tatttatgtc caactattt    1919



      <210> 1948
      <211> 654
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> misc_feature
      <222> (1)...(654)
      <223> n = a,t,c or g


      <400> 1948
 ctccccgtct cttccctggc cttgccctct ctctttctgc cctgtagccg cgggcgtcca     60
 aatgaagctg gaattcctcc agcgcaaatt ctgggcggca acgcggcagt gcagcactgt    120
 ggatgggccg tgcacacaga gctgcgagga cagtgatctg gactgcttcg tcatcgacaa    180
 caacgggttc attctgatct ccaagaggtc ccgagagacg ggaagatttc tgggggaggt    240
 ggatggtgct gtcctgaccc agctgctcag catgggggtg ttcagccaag tgactatgta    300
 tgactatcag gccatgtgca aaccctcgag tcaccaccac agtgcagccc agcccctggt    360
 cagcccaatt tctgccttct tgacggcgac caggtggctg ctgcaggagc tggtgctgtt    420
 cctgctggag tggagtgtct ggggctcctg gtacgacaga ggggccgagg ccaaaagttg    480
 tcttccatca ctcccacaaa cacaagaagc aggacccgct gcagccctgc gacacggagt    540
 accccgtgtt cgtgtaccag cccggccatc cgggaggcca acggggattc gtggagtgcg    600
 ggcccttncc agaaagggta tttgttggtg cangcagatt ccnaacatta aact          654



      <210> 1949
      <211> 512
      <212> DNA
      <213> Homo sapiens


      <400> 1949
 ggacatagag cacactgagg gcaagaggta cttcacctgg gacaaaaaca gattcccaaa     60
 ccccaagagg atgcaagagc tgctcaggaa caaaaagcgt aagcttgtgg tcatcagtga    120
 tccccacatc aagattgatc ctgactactc agtatatgtg aaggccaaag atcagggctt    180
 ctttgtgaag aatcaggaag gggaagactt tgaaggggtg tgttggccag gtctctcctc    240
 ttacctggat ttcaccaatc ccaaggtcag agagtggtat tcaagtcttt ttgctttccc    300
 tgtttatcag ggatctacgg acatcctctt cctttggaat gacatgaatg agccttctgt    360
 ctttagaggg ccagagcaaa ccatgcagaa gaatgccatt catcatggca attgggagca    420
 cagagagctc cacaacatct acggttttta tcatgtaaga catccaaaaa gaattaaact    480
 gggcttgtgt gacccacctt ttggctgaaa aa                                  512



      <210> 1950
      <211> 3914
      <212> DNA
      <213> Homo sapiens


      <400> 1950
 gtgggaggga cagcagggct tagagtgggg gtcattgtgc agatgggaaa acaaaggccc     60
 agagagggga agaaatgccc aggagctacc gagggcaggc gacctcaacc acagcccagt    120
 gctggagctg tgagtggatg tagagcagcg gaatatccat tcagccagct caggggaagg    180
 acaggggccc tgaagccagg ggatggagct gcagggaagg gagctcagag agaaggggag    240
 gggagtctga gctcagtttc ccgctgcctg aaaggagggt ggtacctact cccttcacag    300
 gtcatgctcc atttttccat cgggaccatc aagagggtgt ttgtgtctaa ggctgactgg    360
 gtaactttgg atgagcggtc tctccgctct gagcctgttt cctcatctgt caaatgggct    420
 ctaacccact ctgatctccc agggcggcag acaatgccgt cttctgtctc gtggggcatc    480
 ctcctgctgg caggcctgtg ctgcctggtc cctgtctccc tggctgagga tccccaggga    540
 gatgctgccc agaagacaga tacatcccac catgatcagg atcacccaac cttcaacaag    600
 atcaccccca acctgggctg agttcgcctt cagcctatac cgccagctgg cacaccagtc    660
 caacagcacc aatatcttct tcttccccag ttgaggcatt cgttacagcc ttttgcaatg    720
 gttcttccct gggggaccaa ggcttgacac tcacgatgga attctgggga gggccttgaa    780
 ttttcaacct tcaagggaga ttttccggag gctcagatcc atgaaggctt ccagggaact    840
 cctccgtacc cctcaaccca gccagacacg ccagctccca gctgacccca ccggcaatgg    900
 ccctgttccc ctcagcgagg gccctgaagc ctagttggga taagtttttg ggagggatgt    960
 taaaaaagtt gtaccccacc tcagaagccc ttcacctgtc caaccttcgg gggacacccg   1020
 aaggaggccc aagaaacaga tccaacgatt tacgtgggag aagggtactt caagggaaaa   1080
 tttgttggat ttggtcaagg agctttgaca gagacacagt tttttgctct ggtgaattta   1140
 catctttctt ttaaagggca aatcgggaga gacccttttg aagtcaaagg acacccgagg   1200
 aaagaggact ttcacgttgg accagggcgt accaccgtgg aaggtgccct atgatgaaag   1260
 cgtttagggc atgtttaaca tccaagcact gggaagaagc ctgttccagc ttgggttgct   1320
 gctgatgaaa taacctgggg caattgccac cggcaatctt ccttcctgcc ctgatgaggg   1380
 gaaactacag cacctgggga aaatgaactc accccacgat attcattcac caagtttcct   1440
 gggaaaatga aagacagaag gtcttgccca gctttacatt ttacccaaac tgttcccttt   1500
 attgggaacc ctattgattt tgaaggagcg ttcctggggt tcaactgggg gcatcactta   1560
 agggtctttc aggcattggg gctgaccttt ccgggggtca cagagggagg cacccctgaa   1620
 agctcttcca agggccgtgc ataaaggctg tgcttggacc atcggacgag aaagggactg   1680
 aaagctgctg ggggccatgt tttttaggag gccttaccct gtcttttccc ccccgaggtt   1740
 caatttcaac aaaccctttg tcttcttaat gatttgaaca aaataccaaa cttgaccagg   1800
 cccagcaggc cccagaagac cattacccta tatcccttct cctccccagt cacatggcca   1860
 taggcctgct gatggctcag gaaggccatt gcaaggactc ctcagctatg ggagaggaag   1920
 cacatcaccc attgaccccc gcaacccctc cctttcctcc cctgagtccc gactggggcc   1980
 acatgcagcc tgacttcttt gtgcctgttg ctgtccctgc agtcttcaga gggccaccgc   2040
 agctccagtg ccacggcagg aggctgttcc tgaatagccc ctgtgcccag aaatcttcct   2100
 ctggcctagt tgtggagcct ggcctaagtc gcacattgct ggagatggtg aagctgacca   2160
 gcatgagagg tcagtttcta gaagcccaaa tcccaacagg cataagcctc accctccaat   2220
 atcagctcta tcagaaacaa acaaacaaaa acatgtctta ttcatttgtc cttttcctca   2280
 aatgggtggc acttgggcag ggcagaaggg ctggttatcc aagcttggaa gatgctgaca   2340
 gcagacgctt caatggcagt aggagttttc tgatcactgt cattggtatc acgcttactg   2400
 ttgaaatcgt gacatcagga atgatgaaag gaactagagt cagatggtct ggagcgggga   2460
 atgaggggat gatggggctg gaagagggaa ggaatgaaag gagtgtgaag gaagcgccac   2520
 caaggagagc tgtggaagcc caacccaaag accgcacctg ggatgtcggg aagggccaag   2580
 gtacagaagg agaaggaaga gggttggagg tggagggcca gcagcaccaa ggctcggagc   2640
 cagggacaat accattctct gtctcatggg gcgtcctcct gctggcaggc ctgtgctgcc   2700
 tggtccccag ctccctggtt gaggatcccc aggaagatgc tgcccaaaag acggatacat   2760
 cccaccatga tcaaggggac tgggaggacc ttgcttgcca gaagatctcc tataacgtca   2820
 ccgacctcgc ctttgatttg tacaaagagc tggctgatct atcacaaacc agcaatgtct   2880
 tagtcacccc aacaagcgtg gctatggcct ttgcaatgct ctccctgggg accaaggctg   2940
 acactcgcac agagatcctg gaaggcctga atgtcaacct cacagagacg cctgaggcca   3000
 agatccacga atgcttccag caagttctcc aagccctcag caggccagac acccggctcc   3060
 agctgaccac cggcagtagc ctgtttgtta acaagagtat gaagctagtg gacacgtttt   3120
 tggaggatac caagaagctg taccactcag aagcctcttc catcaacttc agggacaccg   3180
 aggaggccaa agagcagatc aacaattatg tggagaaaag aactggaaga aaagtagtgg   3240
 atttggtcaa acacctgaaa aaagacacaa gtcttgccct ggtggattac atttcctttc   3300
 acggcaagtg gaaagataaa ttcaaggctg agcgcattat ggtagagggc ttccatgtgg   3360
 atgataagac catcatcaga gtgcctatga taaaccacct gggtagattt gacatccacc   3420
 gggacaggga gttatccagc tgggtgctgg cacagcacta tgtggggaac gccactgcct   3480
 tcttcatcct gcccgatcca aagaagatgt ggcagttgga agaaaaattg acctacagcc   3540
 accttgaaaa tatccagaga gcctttgaca taaggtctat caatctacat tttcccaaac   3600
 tgtccatttc tggaacctac aaactcaaga gagtccctag gaatctgggc atcaccaaga   3660
 tcttcagcaa cgaggccgac ctctctggag tcagtcagga ggcacccctg aagctctcca   3720
 aggctgtgca tgtggctgtg ctcaccattg atgagaaagg gaccgaagcc accggagccc   3780
 cccatctgga ggagaaggcc tggtctaagt atcagacagt catgttcaac cgacccttcc   3840
 tggtcatcat caaggagtac atcaccaact ttccgctctt cattggaaaa gtggtgaatc   3900
 ccacccaaaa ataa                                                     3914



      <210> 1951
      <211> 1479
      <212> DNA
      <213> Homo sapiens


      <400> 1951
 aggatgaagg gcggtgaggg ggacgcggtc gagcaggccc cgctgaaccc tgagggcgag     60
 agccctgcag gctcggccac gtaccgggag ttcgtgcacc gcggctacct ggacctcatg    120
 ggggccagtc agcactcgct gcgggcgctc agctggcgcc gcctctacct cagccgggcc    180
 aagctcaaag cttccagccg cacgtctgcc ttgctctcgg gcttcgccat ggtggccatg    240
 gtggaggtgc agctggagag tgaccacgag tacccaccag gcctgctggt ggccttcagt    300
 gcctgcacca ccgtgctggt ggctgtgcac ctctttgcac tcatggtctc cacgtgtctg    360
 ctgccccaca ttgaagctgt gagcaacatc cacaacctca actctgtcca ccagtcgcca    420
 caccagagac tgcaccgcta cgtggagctg gcctggggct tctccactgc cctgggcacc    480
 tttctcttcc ttgctgaagt tgtcctggtt ggttgggtca agtttgtgcc cattggggct    540
 cccttggaca caccgacccc catggtgccc acatcccggg tgcccgggac tctggcacca    600
 gtggctacct cccttagtcc agcttccaat ctcccacggt cctctgcgtc tgcagcaccg    660
 tcccaggctg agccagcctg cccaccccgg caagcctgtg gtggtggtgg ggcccatggg    720
 ccaggctggc aagcagccat ggcctccaca gccatcatgg tacccgtggg gctcgtgttt    780
 gtggcctttg ccctgcattt ctaccgctcc ttggtggcac acaagacaga ccgctacaag    840
 caggaactag aggaactgaa tcgcctgcag ggggagctgc aggctgtgtg agactggtgt    900
 tagccaccgc tcactgcaag cactgcctcc ctccggggtc tgtaagaggc cgcaggggcc    960
 tacagacctc atccccccat cccctggctg gagccacttc cagtggccac tctcaggcag   1020
 agttcagatt cctgcccgca gggtcctctg ggctgggcct tggggcagct cccacattcc   1080
 cagggatttt ccccatcagt ctgtcccttg ggttttgcaa gctactctgc acctgggctg   1140
 gcctcagttg aaggatcatg cagtagatag aggggaggca gggagagctt gtgggacctt   1200
 cagtgctgac tttagccacc atttccattc ctatacagga tgtgaaggtc agaaggcagc   1260
 caattgttgg tttaattttt tttttttttg agacagtctg tttcccaggc tggagtgtag   1320
 tgatacagtc acagctcact gtagcctcga ccttccaggc tcaaaagatg ctcccaccac   1380
 agcctcccag gtagtgagta gctggtacta caggtgtgtg ctgccacacc cgactaaatt   1440
 tttttgtaga gacggggttt cgctgttccc agggtggtt                          1479



      <210> 1952
      <211> 947
      <212> DNA
      <213> Homo sapiens


      <400> 1952
 tcgacccacg cgtccgaaag caatgctttc tcgatctatc tgtggtgaag gacaaaattg     60
 tctttgctgt tgctttaatg ttaaataaat tgcaggctga tacttttgta aaatagaata    120
 aaattgtggc aatgtcagat tcctgtaaaa gtttctgaac actttcggtt tctatactta    180
 cctcattgaa aaaatactta acaagtagtt gtggatgggc actagtccac aaaccacaat    240
 cggagtagca cctgtgttca aaataagcag aagacattcc attttatgaa tgtgtgtact    300
 gaatttgatt tttaacatga cctcattatc tttcttggat tagaattttt tagacaactt    360
 ccctagcagt gacaccctgt ccttcattgc aaggatattc ctgctgttcc agatgatgac    420
 tgtataccca ctcttaggct acctggctcg tgtccagctt ttgggccata tcttcggtga    480
 catttatcct agcattttcc atgtgctgat tcttaatcta attattgtgg gagctggagt    540
 gatcatggcc tgtttctacc caaacatagg agggatcata agatattcag gagcagcatg    600
 tggactggcc tttgtattca tatacccatc tctcatctat ataatttccc tccaccaaga    660
 agagcgtctg acatggccta aattaatctt ccacgttttc atcatcattt tgggcgtggc    720
 taacctgatt gttcagtttt ttatgtgaaa tacctcaact gtttttttca agagctctca    780
 tgatattttg agccttgaca acagttctat acaaattcac ttgtaaacgc tgctgttgcg    840
 taattctaaa cattctctaa gatcatttga aagcacggga actagcggac ccttcaagag    900
 cattccttta ttgggcggcc cccagggggc acacacgctc gcccctc                  947



      <210> 1953
      <211> 5725
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> misc_feature
      <222> (1)...(5725)
      <223> n = a,t,c or g


      <400> 1953
 tttttttttt ttaaggactg cagtatttat tttattttta tattatttat ttattctttg     60
 ttagtttttg gagtgtgggt tttgttttgt tttttgaatt ttttattttg ttctaactcg    120
 gttttattct tattgctcaa ggcttgagtg caactggcct cttctcaagc ntcaacctcc    180
 gccttcttgg gttcgggtaa tgatggttcc acgtcagcgg ccctccgcct tcttgggttt    240
 gcgttaaggg ttccacggtc accgaaccct ccgcctcttg gggttcgggt gatgatgggt    300
 tccaccgntt caagccgggg gggccccccc ccccccccct ccgccctcct tgggtttgcc    360
 gtgaacggtt ccacaatcac cgacccttac gcctcttggg ttcgggtgat gatgggttcc    420
 acgtcagcgg gccctccgcc tcttgggttt gcgtgacggt tccacgtcac cgaccctccg    480
 cctcttgggt tcgggaggtg gttccatctc agccgccctc tgcctcttgg gtttgcgtgg    540
 tttttctgcc tcagcctcct gagtagctaa gggaggtgtc ttgagattat catccgctga    600
 gggtggaagc ggcccccgca gacgctcggc aggtgtcttg atattatcat ctgctgaggg    660
 tggagctgag ggtggaaggg gagtgagctg acgctcagaa ggtgtcttga gattatcatc    720
 cgctgagggt ggaagcggcc ccccgcagac gctcggcagg tgtcttgata ttatcatctg    780
 ctgagggtgg agctgagggt ggaaggggag tgagctgacg ctcggaaggt gtcttgagat    840
 tatcatccgc tgagggtgga agcggccccc gcagacgctc cccgcagacg ctcggcaggt    900
 gtcttgatat tatcatctgc tgagggtgga gctgagggtg gaaagggagt gagctgacgc    960
 tcggaaggtg tcttgagatt atcatccgct gagggtggaa gcggcccccg cagacgctcc   1020
 ccgcagacgc tcggcaggtg tcttgatatt atcatctgct gagggtggag ctgagggtgg   1080
 aaggggagtg agctgacgct cggaaggtgt cttgagatta tcatccgctg agggtggaag   1140
 cggcccccgc agacgctcgg caggtgtctt gatattatca tctgctgagg gtggagctga   1200
 gggtggaagg ggagtgagct gacgctcgga aggtgtcttg agattatcat ccgctgaggg   1260
 tggaagcggc ccccgcagac gctcggcagg tgtcttgata ttatcatctg ctgagggtgg   1320
 agctgagggt ggaaggggag tgagctgatg ctcggaaggt gtcttgagat tatcatccgc   1380
 tgagggtgga agcggccccc gcagacgctc ggcaggtgtc ttgatattat catctgctga   1440
 gggtggagct gagggtggaa ggggagtgag ctgacgctcg gaaggtgtct tgagattatc   1500
 atcggctgat ggtggaagcg gaatccgcag acgctcagca ggtatcttga tattatcatc   1560
 tgctgagggt ggagctgagg gtggaagggg agtgagctga cgctcggaag gtgtcttgag   1620
 attatcatcc gctgagggtg gaagcggccc ccgcagacgg ctcgccaggt gtccttgata   1680
 ttatcatctg ctaagggtga agctaagggt ggaaggggag tgagctgacg ctcggaaggt   1740
 gtcttgagat tatcatccgc tgagggtgga agcggccccc gcagacgctc cccgcagacg   1800
 ctcggcaggt gtcttgatat tatcatctgc tgagggtgga gctgagggtg gaaagggagt   1860
 gagctgacgc tcggaaggtg tcttgagatt atcatccgct aagggtggaa aacggccccc   1920
 cgcaaacgcc tcggccaggt gtccttgaat attatcatct gcctgagggt ggagctgagg   1980
 gtggaaaggg gaagttgagc gcacgctcgg aaggtgtctt gagattatca tctgctgagg   2040
 gtggaagcgg ccctcgcaga cgctccncgc agacgctcgg caggtgtctt gatattatca   2100
 tctgctgaag ggtggagctg agggtggaag gggaagttga gcgcacgctc ggaaggtgtc   2160
 ttgagattat catccgctga gggtggaaag cggcccgcgc agacgctcgg caggtgtctt   2220
 gatattatca tctgctgagg gtggagctga gggtggaagg gggaggttac tgacgctcgg   2280
 aaggtgtctt gagattatca tccgctgagg gtggaagggg atggagcaga gtactcggca   2340
 cgtgtcttga gattatcatc cgctgagggt ggggctgggg gtggagctga gggtggaagg   2400
 ggagtgagca gacactcggg aggtgtcttg agattatcat ccgctgaggg tggaagggga   2460
 gtgagcagac actcgggagg tgtcttgaga ttatcatccg ctgagggtgg aaggggagtg   2520
 agcagacact caggaggtgt cttgagatta tcatccgctg agtgnaaggt agagctgagg   2580
 gtggaagggg agtgagcaca cactcgggag gtgtcttgag attatcatcc gctgagggtg   2640
 gaaggggagt gagcacacac tcgggaggtg tcttgaggct cagggagtta tcagttatag   2700
 aatgttgttg agttggagga ggtggctggt ggcccatcct gttttttaaa gtttcagctg   2760
 tgaggtaggg ccagtagggc aatcctgaag aatgacgatg ctccgctgcc gccattctga   2820
 cccagttgca aagagccttt cttgcagaag gggggatttt gcatttgtgg tagtcctctg   2880
 ctcgccgccg caactcttgc gcacgttgaa acattttctg ttttctggcg gtcttcctct   2940
 ttccattgat tttgtcatga cggttgattt tcgttgtcac cttcctctta cggattttag   3000
 ctctaacttt tgtttccaca tgcctccgta gagtaatgac gtctttcagg ccaattttat   3060
 ttcctcgaaa ggaagaaact cttttctttg tgtgcataca aatggacctc agcccttcct   3120
 gtctacggcg gttggacctc caggctctct gctgtacatc cgtggatcca tcatgtccat   3180
 ttcgagacca gaagatagtc ttcaggagag acacccaaag gtaaactatc cagagggtaa   3240
 tgacaacttt ataacttgtc ggaaacgcaa taatgacatg taaccaagga cttccaccaa   3300
 agtcagtccc acgatgatga tggtcagaca gagtattgat aaccttcctc aggtactcgc   3360
 atgggcatgt cactgacttt acatgctgct gcagctcctt ggtgagctgg ccctggtcat   3420
 gggacaggaa ctgtggggtc aggacaatag agagcttcac catttgcaga atgagaacag   3480
 gggctcatga tgagtgccaa cctcagtttt cttctgtgtg aaacaggaac aatagtttca   3540
 ttcgtcattc agtttctctc aagatttcac gagatcatac ctttaatttt ctccaacaac   3600
 tgattctggt acacagtata ccttaatgcc tgcatccacg gcctcacgtc atgctgttta   3660
 catgaacgta aagcttcgcc gaagagtgga ataagacagt cctctgttga aagtctgtta   3720
 gaaactgtgg tctccaaagc agacgagcaa tacagctgca aggtacttag aactggcaaa   3780
 gactgtgaaa ctgttaaagt agaaagtctc agaggtccaa tagcgatgcg ggatgtttgc   3840
 ttcaagtact ttaccacatt ttcagttata gactgccact tctgatcttg ttctatcggg   3900
 tttaaagcag ttgccaaaca aacagaactt cttaacaatg gaacttcaat ggatttctga   3960
 ggttcccttg gatctggact tcacatgtta cgaagcagtt ttttcatgtc tattttttct   4020
 tttgatcctc cagcaagtag attgatattt tctcctggta acaattctaa ttgctcggta   4080
 cattcaacaa attttccaga ctcaaagctg cttaatgatt ttatatagtt gaagtcagct   4140
 ttcaggttga gggaagtgct actggtactc tttttcaagt catggatagc gttctgccat   4200
 tcctgcacag cagcccaatc ggcagttgag atgtagcact cacatgcttt gtttcctaaa   4260
 taatttataa cctcagggga agagtcagtc ggtttggaca gcacactttt tctggattca   4320
 ccattcagac aatgtttcag gctggcactc ttacacccag cactggctaa ggtgagcacc   4380
 gatttgtcaa agctggagat gcagcaatca acacctgtca tggcacacag gtgttcctgg   4440
 tactccacag aggccttttc aaacctccct tcagcctgtt gagccactga gttaatccac   4500
 agaagatgtt ttccaacaat agatgatgac cagacagcaa ttccctgtat agcttcagga   4560
 caatgaagtt cacatagtgc ttctaccacc atcataatgc ttacttccaa ttcattcccc   4620
 tgagataggc tggttgtttt catctctgta agcaagtcaa agccatgtct cactgtcact   4680
 gcaggctggc ctgccaacaa tcctaccctc atgatggaga gtcgaatccg cgttagccag   4740
 tcctgacaag tttggcgatt ggtatacaaa aaagttctaa tgaccttggg aggtgaagtt   4800
 aaggcattag cacatccctc gtatgcatta tacattaatt tctccagatt ttccagatac   4860
 tgcagaagaa gaacaagtct aagttggttg ttaccatggc cttcatcatt gtctgcagtt   4920
 gtccactgac taacatcctg atcagggttt aatgtgtgac ctgcgagact tcgaatgata   4980
 ccttcaattg tctggaaggt gtcttgagct ctgcccagtg gggttctcag cttagaaaga   5040
 acagtgaatt gtgcagcttc ccatatggcc cactgccaaa ggacagcatc tgtcttcagg   5100
 agattgcgtg gaattgttga ctggtcacgc ttatccagtc tctggcagct atagaacagt   5160
 ctttccaacc aattgtcctt ccctgttcta tgagagttcc catacaaaat aaaactaata   5220
 catcagagaa atcttggggg tggaatgtat tacttggtgc tttactcatg tgacttctta   5280
 atgctaaaga aatttcttga atttctgtgt gattgttatt gcttaggaaa acacctaaag   5340
 gaattgattt caacagtttt ccaaatgctt gtcgaataca agttccacgg tgcactagtt   5400
 ggacacggca aacatcaaca catctctgta aaagatcatc tggcaaggaa gaggatagag   5460
 catgtagact gctgcatgcc tgcagacaga tattcacatc ttcaacgaga gtgtcggcta   5520
 aaaggccttt gcaaaattta tggaaagacg gaagacagaa taaaggtgca tatgtttcgg   5580
 acttcttcat tacaacagct acttccaaag cccaagtcat taacagtttc ctcgtgtcct   5640
 ggttatcttt cttaagtaac attcccagaa gatttaatat aattgagaaa tgtttctttg   5700
 tggccatagt tacagtgctc gtgcc                                         5725



      <210> 1954
      <211> 1293
      <212> DNA
      <213> Homo sapiens


      <400> 1954
 gtattttgga aaaatggtaa agaagtgcag agtcaagtca tagcgactaa taatgggtta     60
 ttttcttaaa ttgtatgctt atgttaattc tcacagtctt tttgtttggg tctgtgacag    120
 atcttacaaa agatctttta gacctatgat tcttaacaaa attaaagaat taagtcggaa    180
 ccaatttccc acaatgtctc atctaagaaa ggactcacag gccagcagcc caggagatga    240
 cgcaatggac aggagtgggc tccctgacct tcaaggaaga tttgagctat ctgggaaaaa    300
 caagacagta tccactggat gcattggaac cccaacccca gcattgggga tattaaggac    360
 attaaaaaag cagccaagtc tatgctagac ccagcacata aatctcattt ccaccctgtg    420
 accccaagtt tagtattctt gtgtttcata tttgatgggt tacaccaggc attactgagt    480
 gttggtgtga gcaagaggtc taatactgtg gttgggaatg agaacgagga aaggggtact    540
 ccttatgcta gcagattcaa agatatgcct aactttattg cccttgagaa gtcatcagtt    600
 ctccgccact gctgtgacct tttgataggc gttgcggctg gatcaagtga taagatttgc    660
 accagcagtc tccaagttca gagacgattc aaggcaatga tggcatctat tggaagactt    720
 tcacatggtg agagtgctga tctgctaatc agctgcaatg cagaatcagc cataggttgg    780
 atcagctcaa gaccgtgggt tggagaatta atgttcacat ttctatttgg agactttgaa    840
 tcccctctac acaagctacg caagtcaagt tagttgccaa gaaagcacag atgacaacct    900
 attaatgctg tgagaatgtt tctagatcag tgcatggatg gctccattgc tctacgggcc    960
 attgtgtctg agatcccagt ctttgaggag aaaaaaaaca atggttaaaa aggcattggg   1020
 gaaatatttt gagtttgggg gtgtactttg ccaccccatt attggggagc tgtcaccacg   1080
 aatgttccca aacttagcaa cagcggcaaa ctactgggcc aagatgagca accccacatt   1140
 tttgggattt aaagctcctg atgttatacc aggatcaacc atcacactcc ctttgcttcg   1200
 aatggcatct accccgtaag atcttgaggg gggagtgttg ggtggaatca tagatccatg   1260
 cactcctaac atgaactaat tctcattatt taa                                1293



      <210> 1955
      <211> 15040
      <212> DNA
      <213> Homo sapiens


      <400> 1955
 gagctcagcc aaatccatgt tgagtttagc accatcacta cccttcgggc cttgtactct     60
 cacgaaggca ctcagccaac tgtggaaaag aaatatacac aggagactca agaaacatct    120
 tattaataca gtatttattt gtcttttctc tgtcaaaccc tgagccaacc acgttcccca    180
 ggctgcctgg ggaggtatag gaaaaggaac acacggggcc aaccagacgc gggagaacta    240
 tgggaggtgg agacggctcc ttcacatggc aaagaggatg agaaaggcta ccatcagaca    300
 aaagagcccc atggcctccg agagggcaaa gcccagaatg gcgtaggaga agagctgttg    360
 cttcagagaa gggttcctgg tagaaggaga agagaaaaga ctgaatttct agttcacaca    420
 aagaaaagga taaatatcta agatgggctc agggagaatc cccctcttca agattatctc    480
 acataataaa gaagctttta gggtaacacc atcatgccca aattcttgcc ctgattcccc    540
 aaaggctcta caggaactga atgaaggggg agcaggcaat ctaaaatcct gtaacatggc    600
 ccaggtataa tcatgacctt cactaatggt tcacccatct cattaccaca aattaagacc    660
 tcttggccca gacacttaat atccagggcc caaataggat ggaagggtct atctagagca    720
 gtgttttcaa actttaagca gaactccaat atagtaaaca tctaaaagcc aaactgcaat    780
 ggtacaaaag tagtggggaa attttaacgg cttggtctcc cctttattct ctaagacagt    840
 ctctggggca taacctcaga atcctaagga tttatggaac accgctcttc tagaagacaa    900
 gagtaagagg gacagattat gttctctcat ttcaaatagt cagaagatct ggggctttaa    960
 gaaactacaa atgggctggg tgcggtggct cacacctgta atcccagcac tttgggaggc   1020
 caaagcaggc ggatcacttg aagccagaag ttggagacca gcctggccaa catggtgaaa   1080
 ccccgtctct actaaaaata caaaaattag gccaggcgcg gtggctcacg cctgtaatcc   1140
 cagcactttg ggaggccgag atgagtagat tgcttgaggt caggagttcg agaccagcct   1200
 ggccaacctg gtgaaaccct gtctctacca aaaatacaaa aattgctggg cgcagtggct   1260
 catgtctgta atcccagcac tttgggaggc cgaagtgggc agatcacgag gtcaggaaat   1320
 cgagaccatc ctagctaata cggtgacacc ctgtctctac taaaaataca aaaaattagc   1380
 caggcgtgtt ggcaggcgct tgtagtccca gctactcagg aggctgaggc aggagaacgg   1440
 cgtgaacccg ggaggcagag gatgcagtga tccaagaccg cagccactgt actccagcct   1500
 gggcgacaga gcaagactct gtctcaaaaa aaaaaaagaa agaaaaaaaa tacaaaaatt   1560
 agctgggggt agcggtgcgt acctgtaatc ccagctactt gggaggctga ggcaagagaa   1620
 ttgcttgaac ccgagaggca gaggttgcag tgagctgaga ttacacagtt gcactccagc   1680
 ctgggtgaca gagtcagact ctgtctcaaa aaaataaaat aaaataaaat aaaaaaataa   1740
 aaaattagcc gggcgtggtg gtgggcacct gtaatcccag ctacttggga ggctgaggca   1800
 ggagaatcat ttgaacccgg gaggcagaga ttgcagtggg ctgagattgt gccactgcac   1860
 ttcagtctgg gagacagcga gactcagtct caaaaaaaaa aaaaaaaaag aagttacaaa   1920
 tggtctatgg ggtttatgag ttgaagtagt atggataaag gactcccagt gttgaaggcc   1980
 catatataat ctgtatttcc cttactctga tacctccaga agtcttgatg ggtaaggtaa   2040
 atcgacacca acatttaaca gaatagtgaa taaagcagca gtcagacttc ttgtttaata   2100
 caaattctta aaaagaactc tatttctcaa aagacattaa gagaacttcc tggtctctag   2160
 aggattaatt tggttttaac tgagttatcc agagctggga gtactaaaca gtcccaggtg   2220
 tcagaaacca ggggctggct gcagtgccag ttttcccagg agtgacagag ggaaattccc   2280
 agagatggga aaaaatagca gtaaagccac tatgttcact gagtctctag aacagggaag   2340
 gtaaactttt tctgtaaagg gccacattgt aaataatttt aggttttgtg ggccgcatat   2400
 agtctctttt gctttaaaac aaaaatgaag ccttttaaaa atgcgaaact attttttttt   2460
 ttgagatgga gtttcactct tttgcccagg ctggagtgca gtggcgtgat ctctactcac   2520
 tgcaacctcc gccttcaggg ttcaagtgat tttcctgcct cagcctcctg agtagctggg   2580
 attacaggca tctgccacca tgcctggcta atttctgtat ttttagtaga gaaggggttt   2640
 caccatgttg gccaggctag tctcgaactc ctgacctcgt gatccgcccg cctcggcctc   2700
 ccaaagtgct gggattatag gcgtaaggca ccacacccgg ccataaaatt atttttagct   2760
 caatcataca aaacctggct atggcccaga tttggccctt aggccttagt ttgccaacac   2820
 atgctctaga ccaaagctgt tcatgaaact ttcttcaatg acacaatgat ataaacattc   2880
 taatacatac atacatacac acacatatat atatatatat atatatatat atatatatat   2940
 atatataaat tttttttttt ttgatggtct cactctgttg cccagactgg aatgcagtgg   3000
 caccatcttg gctcactgta acctctgtct cccgggttca agcaattctc ctgtctcatc   3060
 ctcccgagta gctgggacta caggcgccca ccacaacgcc tggctaattt ttgtattttt   3120
 agcagagaca gggtttcacc atattgacca ggctggtctc aaactcctga cgtcaggtga   3180
 tccactcgcc ttgacctccc aaagtgcagg attacaggca tgaaccacct cgcccagcct   3240
 atatttgttt ttttcttttt tttttttccc caaagtctca ctctgtcacc taggctggag   3300
 tacagtggca tgatctcggc tcacagctca ctgcaacctc cacctcccgg gttcaagcga   3360
 ttcttctgcc tcagcctcct gaatagctgg gattataggt gcacgccccc cttacccagg   3420
 taatttttgt atttttagta gagatggggt ttcgccatgt tggccaggct ggtctcgaac   3480
 tcctgacctc aagcgattca cctgccctgg cctcccaaag tgctgggatt agtgagccac   3540
 tgtgcccagc caaacattct atatttgcat tgttgaatat ggtagcctct agccacatct   3600
 ggctactgag cactcgaaat atggttagcg tgactgaaga actgaaaact gaaactatgt   3660
 atttttaatt aattaaaact aaaattcagg tcaagcgcgg gggctcatgc ctgtaatcct   3720
 ggcagttagg gaggccgagg caggtggatc acttgaggtc aggagtttga gaccagcctg   3780
 gccaacatgg cgaaacccca tctctactaa aaccacaaaa attaggtggg cgtcattgtg   3840
 tgtgcctgta atcccagcta cttgggaggc tgaggcacaa gaatcgcttg aacccagagg   3900
 tagaggtgac agtgagctga gattgcgcca ctgcactcca gcctgggaaa cagagcgtta   3960
 ctgtctcaaa acaaacaaac aaacaaacaa catgtagcta gtggctacag tgtgggatag   4020
 tatagttcta gacccccaaa tattttctga cctttggaaa gcatatcaga taaccagtgg   4080
 agggtccaac ttatcttacc tggcataacc caatgatgaa ggctccccaa acacagtttc   4140
 caatcccagc cccagaaacc agccacccca acttgtggca agccccagct tccaattgaa   4200
 ctttgggctg ctgttgttcg atgttccctt tgaaatgggc gctggttttg gaagtttgcg   4260
 gttaaggaga caagttgagg ttaaggggga catgagactg ccaagcttgc tgaggctctg   4320
 tgaaaaagag gcaggtagaa ggtaaagttt tttgctttgg taacttttgt accatttaaa   4380
 accctttaag ctgccaaatc ccattgtttc tcccccaaac agaaaattgt ttaacgccct   4440
 aaaatgctgg caagtagaac cttttaacgt aggatgtaga cttcaaatgc ctttaagatt   4500
 caggtgtggt caagaagtgt aagactgagg ccctagtcta ttcttgctgc cccaaggaga   4560
 tcatcttcct aggactaaat gcttccaact gaagtcagta gactaggcca agtaatacca   4620
 gttagcagca gtgcacaggg gcatgtgctg ccagtggcaa aagctggagc actatagcat   4680
 acagcgtatt aagtgtcctc catctccacc taaagcccat ggccttggcc attcatgaat   4740
 tttagcctgt gatgactgtc ctcagcattc tacctcctgg ttctggcagg taaccctccc   4800
 cacccatcac ccccaaaacc acagtcccaa ctccactgta aggtacctca tctgtcagta   4860
 tctccggtcg tttcagcacc actgcagata gcggacggct cagcagctgt gaggtgctct   4920
 tgacctagca ggaatgacat acaggggcag gaaggtcaag gaagactgga gaggagtttc   4980
 agaactatgc cacgttgtta catcatcaga caagattttc tttcctctca tggcctttcc   5040
 atcttcacat gtacgttaga gttttggatc attcttcctt ttagcaaagt ctaaattaaa   5100
 gaaccacacc atttctcttg cttctcagac tttgctttaa ggaaagaaag tctacttcct   5160
 ttgggccata agggagcatc caaccttgct atatcctttt atagctcttg agaacaagaa   5220
 gaaatctaag cctcagaagc atttgcctca ctcaacaagg gaaatatata cagatgctcc   5280
 tcaacttacc atagggttat gtgccaataa atccatcata ctttgaaaaa ccatttaata   5340
 ctgctaacct accaaacacc atagtctggc cttcaatgtg ctcaaaaagc ttacactagc   5400
 ttacattagc ttacagttag gtgaaatcac ctagcaacac agtacaccgt agagtactgg   5460
 ttgtttaccc ctgtgattgg gcaggtgact gggagctgtg ggttcctgct gagtattgca   5520
 acagagtatt gtaccacaca ttgctagctt gggaaaagat aaagattcct aattcgaagt   5580
 atggtttctt tctttctttc tttttttttt ttgagacgga gtcttgctgt atcgccaggc   5640
 tggaatgcag tgtcgtgatc tcggctcggc tcactacaac ctccacctcc caggttcaag   5700
 caattctcct gcctcagcct cccaagtagc tgggactaca ggcgccggca accacgccca   5760
 gctaattttt gtatttttag tagagacagg ttttcaccat attggccagg ctggttttga   5820
 attcctgacc tcaggtgatc cacccacctc ggcttcccaa ggtgctggga ttacaggcat   5880
 gagccaccac gcccagcccg aagtatggtt tctaatgaat gcatatcatt tttgcatcat   5940
 cataaagtta aaaaaaaaaa atcttaatct aaagttgggg gccttctgta tgggtaatgg   6000
 tcagcccaca agaaagaagc cagtaacttt ccctgaacac atccttttgg aaaataggaa   6060
 caaagattca tgctcaaaac tcacctcctt ctggtagcct tttctgacta accccaagcc   6120
 agtgacacca aaacagacac atggtgattc atagccaggg ctttaggcat cagataaagt   6180
 gagattcaaa tcttaattct attatcagca gtgtattctc aggataagtc acttaaacct   6240
 ttctaagcct gtattctcat ttatgaaatc aaaatatcat ctcttggggt tgatttgaag   6300
 agtaaatgag attatgtata ccaattagta aactcagtga gtgctaaggc acatggtaaa   6360
 tgctcaataa atggtactcc tttttatttg tgaatgaacc aaccgcctcc tctagctact   6420
 atttcaaaaa tttcttccat actgttgttt ctgagtcaaa tacttttcca atgtgtattt   6480
 atgtaaattt tagcttccta tccaaattta agtcccagaa tgaactcctt agctatggct   6540
 aactcaggac aagatcctac agacagtgca tactcagtcc aagttatgta atctacttat   6600
 atttaccact ctggatggcc agcttacacg acatatagtt tcaggagtag gaataacttg   6660
 atcttggtct agattctcat ctctattctt ctcctaagat ggctgggtaa gaattaactg   6720
 ggcacagcca ggcacggtgg ctcatgccta taatatcagc aatttaggag gccgaggacg   6780
 gcggatcacc tgaggtcagg agttcaagac cagcctgacc aacatggaga aaccctgtct   6840
 ctactcggat cacgaggtca ggagtttgag accagcccgg ccaacatggt gtaaccccat   6900
 ctctactaaa aatacaaaaa ttagctgggt atggtggcag gtgcctgtaa ccccagctac   6960
 ttgggagtct gaggcaggtg aactgcttga acccgggagg cggaggttgt ggtggatcgc   7020
 gccattgcag cctgggcaac aagagcgaaa ctctgtctca aaaaaaaaaa aaaaaaaaaa   7080
 attaactggc cgccaaggga tatggggcag gagagtatct agcaagcatt cactctatcc   7140
 tgttacgcaa tcatagcaga gggccttccc tccccaagaa tctttcttac ttatttactt   7200
 atttatttat tttttgagac agagtcttgc tctgacgccc aggctggagt gcagtggtgc   7260
 gatcttggct cactgcaacc tctacctcct gggttcaagc tattctgttg cctcagcctc   7320
 ctgagtagct gggattacag gcgcccgcca ccatgcccaa ctggttttcg tttttttagt   7380
 agagatgggg tttcgccatg ttggccaggc tggttttgaa ctcctggcct caagtgatct   7440
 gcccgcctgg acctcctctc ccccagcctt gctgtgaaga acaaggtctg atggaaagag   7500
 agagacaaga tgtctctcct ttaaaactct cccagaaaag caggtactca ccaaggaggg   7560
 agtggagaca aacttggagc aggcgaacat tttcaggggg tgaggagctg tggcaggaga   7620
 gctggaatta cagaagcagt attgtaaacg ctccttattc actaaactat atccttatta   7680
 gcagaaaagg ggccctagaa agcttaactg gcccagaaaa cagtgactga ccttaagtca   7740
 ttggcagaaa tagaattaaa accctgaagt catgacttct tccagaaacc ccacacagct   7800
 cccaagattt ccttataatg aagtgacttc ccctggtctg aacaagtgaa cacttgggtt   7860
 caggtaagac ctgttaccca tttccatagc ctcatgattt gcagttgcca caggaatttt   7920
 cccagagtgt cttttgccta agttttcctt agtttttatt caaaaggaac gcttctcaag   7980
 acttcatcat ctggaccttt aaaagttgcc gtttaggctg ggcacgtggt tcacacctgt   8040
 aatcccagca ctttgggagg ccgaggcggg cggatcacga ggtcaggagt tcgagaccag   8100
 cctgaccaac atggtgaaac cccacctcta ctaaaaatac aaaaattagc caggtgtggt   8160
 agcacgcgcc tgtaatccca gctactcagg aggctgaggc aggagaattg cttgaaccca   8220
 ggaggcggag gttgcagtga gacgagacca cgccactgca ctccagcctg ggtgacagag   8280
 cgagacccca tctcaaaaca aacaaacaaa caaacaaaca aacaaaaagt tgccctttag   8340
 agtctttgta gttttgggag atatttgttg aaggccaaga cactggaagg tctccaacaa   8400
 tctctttgct gatccctgga agtatctgat tcctgaaaat acttcaattt cctgtattaa   8460
 taagatgagg aagatcaagg aggaactctg ttattagtct atccaaaagg tattagtggc   8520
 tgggcgcagt ggctcacgcc tgtaatccta gcactttagg aggctgaggc gggtagatca   8580
 cgaggtcagg agttcgagac caggctgacc aacatggaga aaccccgtct ctactgaaaa   8640
 tacaaaatta gtcgggcatg gtggtgcatg cctgtaatcc cagctactca ggaggctgag   8700
 gcaggagaat tgcttgaatc caggaggcag aggctgcggt gagccaagat tgcgccattg   8760
 tactccagcc tgggcaacaa gagggaaact gtctcaaaaa aaaaaaaaaa agtattaaat   8820
 tgtgtctccc caagatctaa agaagatctg acaccctata ggtatctaag ttggtagaag   8880
 tgaacttacc tcaaacagaa ggtgagttaa aaacctaaag gcagggtttc tccaagtgaa   8940
 gtgagaagcc catctgaact agaattatct gggtggtgta cgtattaaaa aatgcatatt   9000
 cttgggcgca acttggacct tcctggtcaa gatctctggg ggagctaggt tcagtggctc   9060
 attcctgtaa tcccaacact gagaagctgg ggcggaaaga taacttgaag ccaggagttt   9120
 gagaccagcc tgggcaaaca tcaagacctc atctctacaa aacataaaat tagccaggtg   9180
 aggtggaagt gcacctgtag tcccagctac tccagaagct gaggcaggag gactgcttga   9240
 acccaggagc tggaggcttc agtgagctat gatcacgcca gttgtccagt atgggcaaca   9300
 acgtgaaacc ctgtctataa acaaacaaaa aagatctctg ggaataaggc tcaagtgccc   9360
 tgtatttcaa acaagtttcc cagatgatta ttaggtatac ttaacgcaag agcgtgaccc   9420
 taaacccagt cttgaaactg tggtagtggt agaggataga cttgaacttg gatcttttaa   9480
 gttacatgct ttctaatatg tcacaggctg aaatactcag tgaatgctta gggctattaa   9540
 ataccacttc attaaatgaa ctgaactcag attgtcccag gttaaaacac ttctgaatcc   9600
 aacatcttaa ttgctcttaa tttatttttt gcccaggcta ttgtggaact cctggcatca   9660
 aaagatcttc ccaccttggc ctcccagtgt tgggattaca ggtgtgagcc accacaccca   9720
 gccttaatta cttttaagtt aatggatgtc ttcaactctt gtcctatcta gaactctgat   9780
 ttttgcctat atgtaactct aacccaattt tgctgccgta ctattcaggt tttcttgggt   9840
 caaaatccaa tagttcttta aggcttttag aaaaagaagg ggtggttctt ttctaaggga   9900
 attatacctt attatcttct ttgtaaaatg cagctcttag ggggattaag tatgttcatt   9960
 tacaaattaa catacataaa gagtttaatg tggtgctggc atataataaa cccacaacaa  10020
 ggggtggcaa ttaagtgatc ccaccattgg ctatctaacc atggcaactc tgcaattgtt  10080
 agcctacaac ttgggcaaag gcactatcca gaatcaggac tccaaaatca tcacgggctt  10140
 tttcctcagt gtagatgagt cacaggggta gtaacttaac tattcctttc cttaaacctt  10200
 cttttccttg taacagcaga atctggggag gttaattaat ccttcacagg aaagctggca  10260
 ggcagggtct catgctggcc ccactagctt ggccttaccc cacctttctg ggcctgctgc  10320
 ctcaacagaa accctcatct ctagcccacc atttgtgact tttacaactt caccagcgtg  10380
 ccgggatgcg agaaaggtac tggtaaataa ctagtgattc caaagcaacc agcctctctc  10440
 ttctgcctta gctatcccaa gccacaacct aacgggaggc gatgttttgg ctttttttcc  10500
 cacttctacc atgttcaagg tttacttttt aaattgaggg gtgctgacta gagggattgg  10560
 tgactttaga cgatccacta tctccattgc tcggagcacc tgaggttctg gggcctaaag  10620
 tctggagatt tcagaataaa gaaggcacaa gtcaggatga gaagagaaag cagagatagg  10680
 aggggagagc ctgggggttg tcacaatctg aaagggccag agggcgagaa aagagtgttt  10740
 gcagggactg ggtggaacag gtgaaaagca gcactccagg atctaacttt ggccagctcc  10800
 aaggtatcct ccccctgcga gacatccaag atggcgccag gcccgcgcgg ttggaggtca  10860
 ccggcacgcg gaagagccaa ctctaaggct aagggatagc ggaagcaaga aagggcgaga  10920
 ggaccagggt gggagcacgc aaggtaagcg cctcaaagca tccgcgcaag gtgaggtgtc  10980
 ccgcgcgcgt gcgcagcgca cagagggctc taggtcccaa ggccttacct gctcccactg  11040
 cagagaagac agagaggggc ggagcagcgg gaagagcgaa aggaaggctc agcgcatgcg  11100
 tgacccgggc caacgagtcg ctcagccacg gatagagtga ttgcaacata caggatcagc  11160
 tcaggcatca cagcgccgcc tgccagggct gtggcggtat ccggccggtt gctccacctg  11220
 gcgttcgaga ggagaaacta cagggagcgc cgactgcaga aatgaggcca actccgcgga  11280
 gtaagccgat ccgtaacgtg gactgcggtt tggtctgtac cgcgtttggg atctcggact  11340
 tgcgtcccct ttccgagcat gcgcagtcgt cacactgcca aaacaaaact cctactcaga  11400
 attcagtgtt aacatacggt cgggattggg gttcagtgcc taaaatgcag caggaggaag  11460
 atcttgggag tcctgctttc tgtcgcgccg ggactctggc atcactggat ggcaaaccgg  11520
 ctccatgggc gaatagtcag caaaatgccg cagctgcttc tggtggcttc gccctttccc  11580
 ccactccccg tttcctcctt tccattccgg tgataaacca tgagagaagc agcatcagcg  11640
 agccagaaga tagggttaaa tatgatccga atccctcttt cctggctcct gggacagtct  11700
 aggaataacg ggcacctgcg acccgctgta aggttgcgag gtcactccag gcttgcccga  11760
 gcctctgctc aggtttcaac tacgcgagtt gggataagca gcgccctccc ctcccgcccc  11820
 catgctctcc tgaacgtggg ttttctctcc cctttcgctc gcccttcccc tgatggaagg  11880
 aggtggggga ggcttcctgg ccctcatctt tcctaggcct ccttgtctcc cagacaggac  11940
 ctgccctgcc ctttggaaca gggcgacaag gcctatccag ttccaaaccc ctgccgtccc  12000
 tgcatcgtgc ttgaacgcag cacgagaaag acgggaaaag ctcaccaaac cccataaaaa  12060
 ataaaaaata aaaagaaagc cgcggctgta aataaaggca aatccgccac tctctgaggg  12120
 gccgtttgtc ctcccctcct tggccccgtc cttcccgccg ccccctcccg gctcccgggc  12180
 cccgcggcgc cccggccccg agctcctcca tttaatcgga tttgggagaa ggggaggata  12240
 aatcacggca gcagctttac ggtcccggag gagaggcgag ccgcagacag gcacaccccg  12300
 gccggcgata aaaaccgccg ctgaaagccc acggagcaat ttcccgggac cccgagcgac  12360
 gccattacag gaatgtaatt ttgcccggat gaggccccga gtttaattat cctcgcggag  12420
 gaatttcaat gcggccaatc catcttgcag gcgggcggca gagggattta tatgggcccg  12480
 ttatttcaca ccgatcctcc atctgcattt ttatggccct gagctcctga aagggagggg  12540
 aaggagtggg gagaaatagg agaagcgggc gagaagagga gggtggtaga ctgcctgtct  12600
 ttcctaaatt cgcatttcca gctccatcag gattctcaca ggttcctctg aaatccccaa  12660
 atctccagtt ttagttgttg attgcgcccc gagcgggcag gtacgtggga aatggaactg  12720
 ggatctttgg gaatcaatca acaggtattt atcaagtacc aagtggtgcc aggcactgtg  12780
 gagatgctgt taggagaaag acaggctagc aaagacacaa gtttatcccc tgaggtctcc  12840
 agacatctcc attcccacca aaacggaatt cttttaagct gtcagcttca catcctcagt  12900
 ggcagagaaa gtccacagtt cttaggagcc accaccccca aacggctgtt gcagctgttg  12960
 cgacaattta gacactcaga tatggctaac aatcccagag gaggatcaga gaaggggcct  13020
 gggaggaagc taaagctggc tctttccaaa agttgttaca gcctgcgatg tttaacactc  13080
 ccttgccctc atagaataat gggttctgcg ttcagacaaa tctgggttcc caaattgctg  13140
 tgtgatcttg agctagctgt ttaaccccct ctaaatctat ttcctcctat gtaaattgag  13200
 aagaataata gtacttatca cacagccaat attgggataa tacatatgaa gcttttagca  13260
 aggtacttgg tacccagtaa gagttcagta attgctagca ttaaaatcat catcgtcacc  13320
 accaccacca ccaccaccac catcaccacc atcatcacca tcatcatcac tgcttctata  13380
 gttaagggca ttgcaactca attctgcact gctacctata tggactgttt attgcaaggt  13440
 ccttgagata gtatctcctg aaagagactc aactacactt taaaaacgtt ttcacctgca  13500
 taagtcatac aaaacaagtt attttacttg ctggtgagtg gagatctgag gggaggctga  13560
 gaatcctggg actattacta cgaggcttga agcaagaaat caaatccgca agggagcagt  13620
 gaggctccaa aaaggaggtt tgtaagggga ggggtgaatt tgaagacagc aaaagatcca  13680
 agagaagctt agctgagggt cggaggatct tcttaactat aggcttgggg aagggtcctt  13740
 ctttcacttc acaaagggaa aaccggggtc caggaaggaa agggtgtgga gacagaacta  13800
 tcctttccaa tcagtccctt tcttttccta ccagaccata taacaaggtt ggactgattg  13860
 gccagttttt ttaatgactg tgagtggcag attctgactg gttggcagcc tccctgccca  13920
 gtggtgacga agaaatgaga ttgatctttc ctttcttagg attggttaac aaccctcagg  13980
 ggggccacag actcatttta attgactgga taggctaaga gagaggttca gcttctctca  14040
 tatagaaatt ccaagtgtcc ttttctacaa aggtcaccaa ggaagggttt tgatttgttt  14100
 atatatgttt ctttggacaa gaaaccatag cttagagcag aaaaatcaag atactcatgc  14160
 aggcatgcca caatgagaaa gagccacgaa agaaacagga gtgattttaa aaacgagaga  14220
 gagagagaga gagagagaga gagagagaga gagaccaggg cacagagaaa tgcgaagaaa  14280
 aaatattgct agagagaaga ggaagggttt aaatggtttg atttccattc ctgatggctt  14340
 aagatgagga tactttatga tgtgttttgc tagatgcaca tgttgccagc aagtggcatg  14400
 gatagaacag ctgtcttcga ggcaggagac tggagtctag tcctagccct gctactaaat  14460
 agttgaataa ctatgctagt tacttcatct ctcgaagctt tagtttcctc atttggaaaa  14520
 atcagggaga gaagtaggtg atctctaaga tttcatccag tgttaacttt ccaggatttt  14580
 ctttctttct gctaaacagg cacttttctg caagttaaag tggaaacttt gcactgccaa  14640
 tactttatac atattgagct tctctattta ttagtgattg ttaatttcaa gctcctgggc  14700
 tgtgatgggc tggtgggaac tgactgatat attttctact tttccttgct aaatcaattc  14760
 cctaagacat caggactgtg agacatcggt aaacctccct acttctaaag aaagaaaaca  14820
 gtagatgaag gaagggaaag gatcactggt atccaggctt ctgagggagg aatcagtagg  14880
 agagatggtg gcagagggat gaccaaaaac atttttgctg gggaagaact tcaccttcct  14940
 ttgaatttgt ttatttttta atttatttta ttttttggag acagggtctt gttctgttac  15000
 ccaggctggg gtgcggtgac acgatcatgg ctcactgcag                        15040



      <210> 1956
      <211> 4871
      <212> DNA
      <213> Homo sapiens


      <400> 1956
 tttcgtgctg ctctcgcgat atttgcgcga gcctgcttcc ttctttcctc ccttgccagt     60
 ctgcctgtct tcctccccgt cttccctgcc cggcctcccc cttcttcccc cgctggcccc    120
 ctccccggag ggataatatg gtctccggcg atggacgccc caaaagcagg atacgccttt    180
 gagtacctta ttgaaacatt aaatgacagt tcacataaga agttcttcga tgtatctaaa    240
 cttggcacca agtatgatgt tctgccttac tcaatacggg tcttgttgga agctgctgta    300
 cgaaattgtg atggcttttt aatgaagaag gaagatgtta tgaacatttt agactggaaa    360
 accaaacaaa gcaatgttga agtgcccttt ttccctgccc gtgttcttct tcaagatttt    420
 actggaatac cagcaatggt ggattttgct gctatgaggg aggcagtgaa aactcttgga    480
 ggtgatcctg agaaagtcca tcctgcttgt ccgacagatc ttacagttga ccattcttta    540
 caaattgact tcagtaaatg tgcaatacag aatgcaccaa atcctggagg tggtgacctg    600
 cagaaagcag gaaagctctc tccacttaaa gtgcagccta agaagcttcc ctgcagaggc    660
 cagactacct gccgaggatc ttgtgattct ggagaactag gccgaaactc aggaacattt    720
 tcttcgcaga ttgagaatac acccatcctg tgtccttttc atttgcaacc agtgcctgaa    780
 cctgaaacag tgttaaaaaa tcaagaagta gaattcggca gaaatcgaga gaggcttcag    840
 ttttttaagt ggagttcaag agtttttaag aatgtggcag ggatccctcc tggaactgga    900
 atggctcatc aaataaactt agaatatttg tcaagagtgg tttttgaaga aaaagacctc    960
 ctcttcccag acagtgtagt cggcacagat tcacacataa cgatggtgaa tggtttaggg   1020
 attctggggt ggggggttgg aggcattgaa acagaagcag ttatgcttgg tctgccagtt   1080
 tctcttactt taccagaggt ggttggatgt gagttaactg ggtcatcaaa cccttttgtt   1140
 acatccatag atgttgttct tggtattaca aagcacctca ggcaagtagg agtggctgga   1200
 aagtttgttg agttttttgg aagtggagtt tcacaattat ctatagttga tcgaactaca   1260
 atagcaaaca tgtgtccgga atatggtgct atcctcagct ttttccctgt tgacaatgtg   1320
 acattaaaac atttagaaca tacaggtttt agcaaagcca aactcgaatc aatggaaaca   1380
 taccttaaag ctgtgaaatt gtttcgaaat gaccagaatt cttcaggaga acctgaatac   1440
 tcccaggtga tccagattaa tctgaattca atagttccat ctgttagtgg tccaaaaaga   1500
 cctcaggata gagttgctgt gacagatatg aaaagcgatt tccaggcttg cttaaatgaa   1560
 aaggttggat ttaaaggctt ccaaattgca gctgaaaaac aaaaggatat tgtctccatt   1620
 cattatgaag gaagtgaata taagctgtct catggatcag tggtcattgc tgcagttatc   1680
 agttgtacca ataattgcaa tccatctgtc atgcttgctg caggtctttt ggctaaaaag   1740
 gctgttgaag ctggtctgcg tgttaaacct tatataagaa caagtttatc tccaggcagt   1800
 gggatggtta cacattacct cagttcaagt ggagtattac catatctaag taagcttgga   1860
 tttgaaatcg ttggctatgg atgttcaact tgagtgggaa atacagcacc cttatcagac   1920
 gcagttttaa atgcagtaaa acagggtgat ttggttacct gtggaatttt atctggaaac   1980
 aaaaattttg aaggtcgtct ttgtgattgt gttcgtgcca attatcttgc ctctccaccc   2040
 ttagtggtag cttatgccat agcaggcaca gtgaatatag attgccagac agaaccttta   2100
 ggtactgacc ccaccggcaa gaacatttac ctgcatgata tttggcctag tcgagaagaa   2160
 gttcatcgag tagaggaaga acatgttata ctatccatgt ttaaagcatt aaaagataaa   2220
 atagaaatgg ggaataaacg gtggaattcc ttagaagcac cggattcagt tttgtttcca   2280
 tgggacttaa agtctactta tatcagatgc ccttcatttt ttgataaact taccaaagag   2340
 ccaattgcac tccaggccta ttgaaaatgc ccatgtctta ttatatttgg gagactctgt   2400
 cacaaccaga tcatatatca cctgccagaa agtatcgcta ggaatagtgc tgccgctaag   2460
 tatttgacaa acagaggcct tacccctcgt gaattcaact cttacggagc tcgaagaggt   2520
 aatgatgctg taatgacaag aggcactttt gcaaatatca agctttttaa taagtttatt   2580
 ggaaaaccag ctcctaaaac aattcatttt ccatcaggac agacgctaga tgtatttgag   2640
 gctgcagagc tgtaccagaa agaaggtatc ccactgatta ttttagcagg aaagaaatat   2700
 ggttcaggaa actccagaga ctgggctgcc aaaggaccgt atttactggg tgtgaaagct   2760
 gttttggccg aaagttatga aaaaatacac aaagatcatt tgattggaat tggcatagct   2820
 ccacttcagt tccttccagg agaaaatgca gattccttgg gcctctccgg tagagaaaca   2880
 ttttctttaa catttcctga agaactgtct cctggaatta cattgaatat acagacaagc   2940
 actggaaaag tattcagcgt gattgcttcg tttgaagatg atgtggaaat aacattatac   3000
 aaacatggag gattattaaa ctttgtggca cgaaaattct catagtatct acttaccata   3060
 gatacctttc ataactggta actgcaaagc cttttgtgct ggacccagga atccttacca   3120
 tggagcagca gatagtccca gtatactcac ttatctcatc catggatgta aatgatgatg   3180
 aatcaacata gtaactgaaa tgaaatcttc ttgattttaa ataatatacg aatggtgcta   3240
 ttaatattgc taaaatcaac gtgtgaagtg tgttgtggaa gagacctgta agtatggggg   3300
 ggggcgatat tttatcagac cattttgtaa ataaaggcag aatttgtgtt gaagattctt   3360
 atatgaataa ccttcctgga tttgtttagt tttgcaccaa taaaactgtg tactactgtt   3420
 tgttggttta agagtagcag attgaaatat aagaagccag attagactct aaaattgtgg   3480
 ccattgggaa tctcatttat aaatggacct tttaagtata ttaattcctc ttcagaattg   3540
 agctgggaca catttgggca ttcttagttt gtcatataac caggtttatc cttagtctaa   3600
 ctgcaaggga tagaacctgc cccaggtcac caatccattc tggtccaatc ccagcccaag   3660
 gttcccttcc cacatatgaa gatggaccat ggcaggatac aactgattgt gtggcaccat   3720
 gtattagcag tgggaatatg tatcacatat gatgcagcct ttcatatttc agcagtttgc   3780
 cactgtgact gtctggcaag cccccagatg gcgttatatt aattggatta gattattttg   3840
 ctcaccttat gtaatactgt aacttcctat aacctaatat tttcggtatc attaaccaaa   3900
 atttcacact catagttgct aaagagaatg ttattcaatc attaaactct gaactgattt   3960
 cttctataca tttaaattat ccaccctcaa taatacgggt gctcaaccct atgcattttt   4020
 taagtgttgc tatttcttaa ttaaattgat ttcctgtcat tttgaatcat ttatcacctg   4080
 cgatgcatga ttctattaat tttgttatgt tactgtttta accaaagctg accgtaagga   4140
 taaaacactt aagttgttgc tgagtactat atatcctcaa tatgcatgtc tgcccatcac   4200
 atcaaatgtt ctgtcaacaa gatgtttggt aatttttttt aaaaaggttg gaaaattaat   4260
 tatagaaggt tctatactgt ttttttaatt aagaaactaa atctagcagg ctaaaggtta   4320
 attgtagtga ttttttttca catagatatc tttctatgac ctagttagtt actgcaattc   4380
 agaattagtt cacattgcat aaagaattac ttgttgtaag caaaatgctg aaactaccaa   4440
 accagtggat gaagaccact aagaactttg cacataatca tacaatcttt tgaaaatatt   4500
 ttgcaaatat gtgtttagac aataagatgg actagagttc gacaaaatga tttctttatt   4560
 taaattttgt ataagtattt tcttcgacac tttcaaatta tattgtgttc ttgatatatg   4620
 ctgtatattt atttgttagt gcatgtgttt ttaatttaca tgaaaacatg agttaggaga   4680
 aattacaggt tgaaagatga aatgcctgta tgtgctctga agaaatggta attccagatt   4740
 gtgcaggggg aaacaaatct attttgtttt gttttgtttt ttgagacgga gtcttgccct   4800
 gtggctgggc tggagtgcaa tggcgcgatc ttggctcact ggcacctccg cctcccggga   4860
 tcagggtatt c                                                        4871



      <210> 1957
      <211> 1646
      <212> DNA
      <213> Homo sapiens


      <400> 1957
 cggacgcgtg gggaccaccg ttatgtatta ggagatttta gttaggatat ttagaaagaa     60
 aaagagaatc tgccattcct tttcttctct cttcaacctc agtacctcca aatcttggct    120
 gcatggaagt atctttggtg acatcaactc ttctccaagt gaagacaact ggttgaaggg    180
 gaccaggagg ttggacacag accattgcaa tggaaatgca gatgatttag actgttcttc    240
 tctgactgat gactgggagt cagggaagat gaatgcagag tctgtgatca cctcctcttc    300
 cagccacatc atatctcagc ctcctggagg aaactcccat agcttgtctc ttcagtccca    360
 gttgacagct tctgaacgtt tccaagagaa tagttcggat cattcagaaa ccaggttgtt    420
 gcaagaggtc ttctttcagg caatcctgct tgctgtgtgc ttaatcattt ctgcatgtgc    480
 aagatggttt atgggagaaa tattagccag tgtcttcaca tgctcattga tgataactgt    540
 agcttatgtg aaatcattgt ttctcagcct tgccagctat ttcaaaacca ctgcctgtgc    600
 tcggtttgtc aaaatttgac aaccatttag gaatgccttc gatgaatgtc ctccatctga    660
 atatctggaa attgtccaac ttgcagtcta cttggaatca agtgttttat tggaagggag    720
 taagcgagta atggagaaaa agccatttta gtttgactat gtgattttaa aatgatctca    780
 ggtttttcca tcaaaattat aatatgctca tgaaaataat attaatttgc cttccctttg    840
 caaacaccgg cagttgaaag gaaaaggacg gggaatgtga tggaaaagag accgcctgga    900
 ataaatgtcc ccctatgatt ctttaaggca gtggttctcg agcttgaatt ttcattagga    960
 aattctgtga ggagcttgta accagatttc tgggtctgcc acatgcacct atctcttgct   1020
 gaattgcttt aatagaataa tgagagcaag tttgtctaac taataccaac ctgacaactt   1080
 gaataacaat aaatgcaatt tggtacataa attataatgc tgcaaaagtt tgtcattcac   1140
 ctcagtggag tgacttgata ttaggtggta acccgtagat gatggttaat atgaaaatgg   1200
 acaggaaaga agcattttct gaaagttata ttcttttgaa ccacgttcta aacccaagtt   1260
 tttaatcttc ttggggctcg taattacctt tcactttaat gtcacttaaa gatataacac   1320
 agaaaaatgc cttgagggca aaatataggc aaaacaccaa tgcgctttca aatgcatgaa   1380
 aatggtgcag ttgtaccctt gagccttgac tcaagggctg tagatgttcc ctttccaccc   1440
 cccacacttg gtgcgtgttc acaaagcaaa tatggcctgt aattcaaatt tgttctatgt   1500
 gatactctct gagtaaaaac tcatacatgc agaaaattgt ctttgctcga aatgataatg   1560
 ccaaaatata actttatata taatttgcat ttagtacatt tttggttaaa aaataaacta   1620
 ataaataagt gaagtcatca gcaaaa                                        1646



      <210> 1958
      <211> 1646
      <212> DNA
      <213> Homo sapiens


      <400> 1958
 cggacgcgtg gggaccaccg ttatgtatta ggagatttta gttaggatat ttagaaagaa     60
 aaagagaatc tgccattcct tttcttctct cttcaacctc agtacctcca aatcttggct    120
 gcatggaagt atctttggtg acatcaactc ttctccaagt gaagacaact ggttgaaggg    180
 gaccaggagg ttggacacag accattgcaa tggaaatgca gatgatttag actgttcttc    240
 tctgactgat gactgggagt cagggaagat gaatgcagag tctgtgatca cctcctcttc    300
 cagccacatc atatctcagc ctcctggagg aaactcccat agcttgtctc ttcagtccca    360
 gttgacagct tctgaacgtt tccaagagaa tagttcggat cattcagaaa ccaggttgtt    420
 gcaagaggtc ttctttcagg caatcctgct tgctgtgtgc ttaatcattt ctgcatgtgc    480
 aagatggttt atgggagaaa tattagccag tgtcttcaca tgctcattga tgataactgt    540
 agcttatgtg aaatcattgt ttctcagcct tgccagctat ttcaaaacca ctgcctgtgc    600
 tcggtttgtc aaaatttgac aaccatttag gaatgccttc gatgaatgtc ctccatctga    660
 atatctggaa attgtccaac ttgcagtcta cttggaatca agtgttttat tggaagggag    720
 taagcgagta atggagaaaa agccatttta gtttgactat gtgattttaa aatgatctca    780
 ggtttttcca tcaaaattat aatatgctca tgaaaataat attaatttgc cttccctttg    840
 caaacaccgg cagttgaaag gaaaaggacg gggaatgtga tggaaaagag accgcctgga    900
 ataaatgtcc ccctatgatt ctttaaggca gtggttctcg agcttgaatt ttcattagga    960
 aattctgtga ggagcttgta accagatttc tgggtctgcc acatgcacct atctcttgct   1020
 gaattgcttt aatagaataa tgagagcaag tttgtctaac taataccaac ctgacaactt   1080
 gaataacaat aaatgcaatt tggtacataa attataatgc tgcaaaagtt tgtcattcac   1140
 ctcagtggag tgacttgata ttaggtggta acccgtagat gatggttaat atgaaaatgg   1200
 acaggaaaga agcattttct gaaagttata ttcttttgaa ccacgttcta aacccaagtt   1260
 tttaatcttc ttggggctcg taattacctt tcactttaat gtcacttaaa gatataacac   1320
 agaaaaatgc cttgagggca aaatataggc aaaacaccaa tgcgctttca aatgcatgaa   1380
 aatggtgcag ttgtaccctt gagccttgac tcaagggctg tagatgttcc ctttccaccc   1440
 cccacacttg gtgcgtgttc acaaagcaaa tatggcctgt aattcaaatt tgttctatgt   1500
 gatactctct gagtaaaaac tcatacatgc agaaaattgt ctttgctcga aatgataatg   1560
 ccaaaatata actttatata taatttgcat ttagtacatt tttggttaaa aaataaacta   1620
 ataaataagt gaagtcatca gcaaaa                                        1646



      <210> 1959
      <211> 1646
      <212> DNA
      <213> Homo sapiens


      <400> 1959
 cggacgcgtg gggaccaccg ttatgtatta ggagatttta gttaggatat ttagaaagaa     60
 aaagagaatc tgccattcct tttcttctct cttcaacctc agtacctcca aatcttggct    120
 gcatggaagt atctttggtg acatcaactc ttctccaagt gaagacaact ggttgaaggg    180
 gaccaggagg ttggacacag accattgcaa tggaaatgca gatgatttag actgttcttc    240
 tctgactgat gactgggagt cagggaagat gaatgcagag tctgtgatca cctcctcttc    300
 cagccacatc atatctcagc ctcctggagg aaactcccat agcttgtctc ttcagtccca    360
 gttgacagct tctgaacgtt tccaagagaa tagttcggat cattcagaaa ccaggttgtt    420
 gcaagaggtc ttctttcagg caatcctgct tgctgtgtgc ttaatcattt ctgcatgtgc    480
 aagatggttt atgggagaaa tattagccag tgtcttcaca tgctcattga tgataactgt    540
 agcttatgtg aaatcattgt ttctcagcct tgccagctat ttcaaaacca ctgcctgtgc    600
 tcggtttgtc aaaatttgac aaccatttag gaatgccttc gatgaatgtc ctccatctga    660
 atatctggaa attgtccaac ttgcagtcta cttggaatca agtgttttat tggaagggag    720
 taagcgagta atggagaaaa agccatttta gtttgactat gtgattttaa aatgatctca    780
 ggtttttcca tcaaaattat aatatgctca tgaaaataat attaatttgc cttccctttg    840
 caaacaccgg cagttgaaag gaaaaggacg gggaatgtga tggaaaagag accgcctgga    900
 ataaatgtcc ccctatgatt ctttaaggca gtggttctcg agcttgaatt ttcattagga    960
 aattctgtga ggagcttgta accagatttc tgggtctgcc acatgcacct atctcttgct   1020
 gaattgcttt aatagaataa tgagagcaag tttgtctaac taataccaac ctgacaactt   1080
 gaataacaat aaatgcaatt tggtacataa attataatgc tgcaaaagtt tgtcattcac   1140
 ctcagtggag tgacttgata ttaggtggta acccgtagat gatggttaat atgaaaatgg   1200
 acaggaaaga agcattttct gaaagttata ttcttttgaa ccacgttcta aacccaagtt   1260
 tttaatcttc ttggggctcg taattacctt tcactttaat gtcacttaaa gatataacac   1320
 agaaaaatgc cttgagggca aaatataggc aaaacaccaa tgcgctttca aatgcatgaa   1380
 aatggtgcag ttgtaccctt gagccttgac tcaagggctg tagatgttcc ctttccaccc   1440
 cccacacttg gtgcgtgttc acaaagcaaa tatggcctgt aattcaaatt tgttctatgt   1500
 gatactctct gagtaaaaac tcatacatgc agaaaattgt ctttgctcga aatgataatg   1560
 ccaaaatata actttatata taatttgcat ttagtacatt tttggttaaa aaataaacta   1620
 ataaataagt gaagtcatca gcaaaa                                        1646



      <210> 1960
      <211> 1846
      <212> DNA
      <213> Homo sapiens


      <400> 1960
 ttttatcatt gcacatccag atactgtttt aggtgagctg agctatttcg ttactgagaa     60
 aatgataagt atccatttag aatgttcatg taatgtttgg agagttttgt attatggatt    120
 caacttatat ataatatata taaggtacat aatatgcaat tatatatctt gatatatatt    180
 atatataaaa taatatacct aagtgttttt ttaaactatg ggagtgtatt ataaaatcaa    240
 taataatatg caaacagttg tgcctgtgta tttgaactac atacaggtat gttgttatta    300
 acagatatat ttaacattta tttactatgg gagccatttc ctaattgaat tgcgtaatta    360
 ctagaccaga atgcatatgc tactatacat tgatttactg cctgttttta cactgccatt    420
 acctttcatg ttatccatga tgttgaacat gggaggcatt tttaatggac caaattttta    480
 gaaaaattag tttttggatt tttttttaag ttctgtatac tgttttgaat gaactttatt    540
 tgcagctatt ctgggatgtc agtttaataa ttcaggtact gaattttatt gcttgctaat    600
 tgtgcctttc cgttgctaaa ttaaggaaat gctatgtgta ctgtggatgt aaaaataagg    660
 acattaactt tatcttaagt tacatataat caagcaaata ttttaaaaaa tgtatgtcag    720
 ggtgacaggc ataaaagtaa attaccctta actctttagc ctttatttag aaagaaatgt    780
 gggaatgggc taaactttct caccaattta ttagaaagct aaatgggtaa atacttccct    840
 ttttgtagat atttttctgt gcattgtaag ttataggagc aggacatatt tttttgtaca    900
 ttgtcttgat tgtttatact gcaggtaggt atttccagtg aatggaaacg ttgaaattta    960
 tagatgggac aatgcacata cttcatatgt aaacaaagca tttttctaaa taatttggga   1020
 aaggattgga tttagcaccg ttaactttta atacccattt attgggctat ttaaggtaaa   1080
 ttattaaaac ctaaaattag tatccgtatt ttagatccta ttattttttc aactttctat   1140
 tattttcaca gtggaaaatt tgcgtatagt attaaactat tcttttttct gtctaccttt   1200
 atattttgaa gtgtggttgt acttacgtta atagtaagtg tatttgtaga aagtttttca   1260
 taaagaagag attaactttc catataaata aataccaggt atggaaatta ctggttttag   1320
 tggcatatcc gtatggatta tccaggaact atcacttcag gatgtttcta ttttggggca   1380
 cccttaacta tttgagcccc atatttttat aattcctgat tgagaattta aggggccatg   1440
 gtaattttta ccccaaaacc tgaaagcctg gtaattttaa agtaaagcca acctaaattt   1500
 acccctttac cttattaggt taaaaggaaa cccaaggcat gtaggaaaat attggtacgt   1560
 tggaaaaatg tgaaaagagc tttactttca aaatgtatgt ttaatgaatt gaattttagg   1620
 gaccgtttcc cataatttgg gcctatgcta tcctgttgat ttttatgtct agcttaaaag   1680
 gtatttgaaa atgttccatt tgtgttttaa taatttttgg cccttgaaca gctcttatgc   1740
 ctaaggtatt ttaaaataaa agccaaattg aagattaaca aaaataaaga aacaaaaaaa   1800
 agctgggggg ggccttttaa aaaaaccctt gggggggccc agtttg                  1846



      <210> 1961
      <211> 1902
      <212> DNA
      <213> Homo sapiens


      <400> 1961
 gttccacctg gcggctggct ctcagtcccc tcgctgtagt cgcggagctg tgtctgttcc     60
 caggagtcct tcggcggctg ttgtgtcagt ggcctgatcg cgatggggac aaaggcgcaa    120
 gtcgagagga aactgttgtg cctcttcata ttggcgatcc tgttgtgctc cctggcattg    180
 ggcagtgtta cagtgcactc ttctgaacct gaagtcagaa ttcctgagaa taatcctgtg    240
 aagttgtcct gtgcctactc gggcttttct tctccccgtg tggagtggaa gtttgaccaa    300
 ggagacacca ccagactcgt ttgctataat aacaagatca cagcttccta tgaggaccgg    360
 gtgaccttct tgccaactgg tatcaccttc aagtccgtga cacgggaaga cactgggaca    420
 tacacttgta tggtctctga ggaaggcggc aacagctatg gggaggtcaa ggtcaagctc    480
 atcgtgcttg tgcctccatc caagcctaca gttaacatcc cctcctctgc caccattggg    540
 aaccgggcag tgctgacatg ctcagaacaa gatggttccc caccttctga atacacctgg    600
 ttcaaagatg ggatagtgat gcctacgaat cccaaaagca cccgtgcctt cagcaactct    660
 tcctatgtcc tgaatcccac aacaggagag ctggtctttg atcccctgtc agcctctgat    720
 actggagaat acagctgtga ggcacggaat gggtatggga cacccatgac ttcaaatgct    780
 gtgcgcatgg aagctgtgga gcggaatgtg ggggtcatcg tggcagccgt ccttgtaacc    840
 ctgattctcc tgggaatctt ggtttttggc atctggtttg cctatagccg aggccacttt    900
 gacagaacaa agaaagggac ttcgagtaag aaggtgattt acagccagcc tagtgcccga    960
 agtgaaggag aattcaaaca gacctcgtca ttcctggtgt gagcctggtc ggctcaccgc   1020
 ctatcatctg catttgcctt actcaggtgc taccggactc tggcccctga tgtctgtagt   1080
 ttcacaggat gccttatttg tcttctacac cccacagggc cccctacttc ttcggatgtg   1140
 tttttaataa tgtcagctat gtgccccatc ctccttcatg ccctccctcc ctttcctacc   1200
 actgctgagt ggcctggaac ttgtttaaag tgtttattcc ccatttcttt gagggatcag   1260
 gaaggaatcc tgggtatgcc attgacttcc cttctaagta gacagcaaaa atggcggggg   1320
 tcgcaggaat ctgcactcaa ctgcccacct ggctggcagg gatctttgaa taggtatctt   1380
 gagcttggtt ctgggctctt tccttgtgta ctgacgacca gggccagctg ttctagagcg   1440
 ggaattagag gctagagcgg ctgaaatggt tgtttggtga tgacactggg gtccttccat   1500
 ctctggggcc cactctcttc tgtcttccca tgggaagtgc cactgggatc cctctgccct   1560
 gtcctcctga atacaagctg actgacattg actgtgtctg tggaaaatgg gagctcttgt   1620
 tgtggagagc atagtaaatt ttcagagaac ttgaagccaa aaggatttaa aaccgctgct   1680
 ctaaagaaaa gaaaactgga ggctgggcgc agtggctcac gcctataatc ccagaggctg   1740
 aggcaggcgg atcacctgag gtcaggagtt caagatcagc ctgaccaaca tggagaaacc   1800
 ctactaaaaa tacaaagtta gccaggcatg gtggtgcatg cctgtaatcc cagctgctca   1860
 ggagcctggc aacaagagca aaactccagc tcaaaaaaaa aa                      1902



      <210> 1962
      <211> 448
      <212> DNA
      <213> Homo sapiens


      <400> 1962
 gactactagt ccagcgcggt ggaattcgtc gggaagggta tcaaggaata acaccctatt     60
 gtgggcttgc ggagaatggg ggacttcaag gcgtgtcagt ttcaggaggg tgagggcagg    120
 agcgtgggtg gagtcagcag gtccccatga tggccctcac tgagagcttc gcccttgtct    180
 cctacaagct ctgactccat tcccagtggg cacccagcac ctccaacccc tccacagccc    240
 ccaacccagc ctctgtcgga ggcgaattct cagagtgagg gttccctgtc acttgagaga    300
 aggttccctg tgacgtgacc ttgggggacg tcattgccct ttctgtcccc acccaccccc    360
 tcggcagttc tgttggccag gactttggcc tatacaaagg atgggggttg tggctgtgga    420
 gcggaactgg ttctcacccc tattaagg                                       448



      <210> 1963
      <211> 1235
      <212> DNA
      <213> Homo sapiens


      <400> 1963
 cccacgcgtc cgcccacgcg ttcgcgtaga gggacgtgcc ctctatatga ggttggggag     60
 cggctgagtc ggccttttcc gcccgctccc ccctcccccc gaggcgccgc tccggctgca    120
 ccgcgctcgc tccgagtttc aggctcgtgc taagctagcg ccgtcgtcgt ctcccttcag    180
 tcgccatcat gattatctac cgggacctca tcagccacga tgagatgttc tccgacatct    240
 acaagatccg ggagatcgcg gacgggttgt gcctggaggt ggaggggaag atggtcagta    300
 ggacagaagg taacattgat gactcgctca ttggtggaaa tgcctccgct gaaggccccg    360
 agggcgaagg taccgaaagc acagtaatca ctggtgtcga tattgtcatg aaccatcacc    420
 tgcaggaaac aagtttcaca aaagaagcct acaagaagta catcaaagat tacatgaaat    480
 caatcaaagg gaaacttgaa gaacagagac cagaaagagt aaaacctttt atgacagggg    540
 ctgcagaaca aatcaagcac atccttgcta atttcaaaaa ctaccagttc tttattggtg    600
 aaaacatgaa tccagatggc atggttgctc tattggacta ccgtgaggat ggtgtgaccc    660
 catatatgat tttctttaag gatggtttag aaatggaaaa atgttaacaa atgtggcaat    720
 tattttggat ctatcacctg tcatcataac tggcttctgc ttgtcatcca cacaacacca    780
 ggacttaaga caaatgggac tgatgtcatc ttgagctctt catttatttt gactgtgatt    840
 tatttggagt ggaggcattg tttttaagaa aaacatgtca tgtaggttgt ctaaaaataa    900
 aatgcattta aactcatttg agagaatgcc ttttagttta atgcatattt aaactaaatt    960
 gatcctgtag tgttcctgga gaagctagag cctgattgta ggctactact catcaattaa   1020
 cttctacagt ggagactact tctgggactg gaatataaaa aagaatcaaa ggttctgatt   1080
 ttgagttgca ataaagggaa agaccatgct catagcagtg ccaacatctg aagtgtggag   1140
 ccttacccat ttcatcacct acaacggaag tagttaactg gaagagatta ccaagagaat   1200
 aaaaagagac tcattcagtg gaagcaaaaa aaaaa                              1235



      <210> 1964
      <211> 436
      <212> DNA
      <213> Homo sapiens


      <400> 1964
 gggtgcccag aggatgcgac atcctcatcg tctacagccc ggatgccgag gaatggtgcc     60
 agtacctgca gaccctgttc ctgtccagtc ggcaggtccg cagccagaag atactgactc    120
 acaggctggg ccccgaggcc tccttctcgg cagaggacct aagccttttc ctcagcaccc    180
 gctgtgtcgt ggtgctgctg tccgcggagc tggtgcagca cttccacaag cccgccttgc    240
 tgcccctgct gcagagagct ttccatcctc cgcaccgcgt ggtcaggctg ctctgcggcg    300
 tgcgggacag cgaggagttc ctagacttct ttccagattg ggcccattgg caggagctca    360
 cctgtgacga tgtatgcctt agacctacgt ggcagctgtg aaaaaagcca tttccgaagg    420
 taaggatttc ttctaa                                                    436



      <210> 1965
      <211> 975
      <212> DNA
      <213> Homo sapiens


      <400> 1965
 gtccagtgtg gtggaattcc gccgccactg tccggccaca gcctaacgct cttcgctgtc     60
 gtttgcggtc tcgcgcaggg cggccccggt tctggtgttt ggcgtcggaa ttaaacaacc    120
 accatgtcga gcaaaaaggc aaagaccaag accaccaaga agcgccctca gcgtgcaaca    180
 tccaatgtgt ttgccatgtt tgaccagtca cagattcagg agttcaaaga ggccttcaac    240
 atgattgatc agaacagaga tggcttcatc gacaaggaag atttgcatga tatgcttgct    300
 tctctaggga agaatcccac tgatgcatac cttgatgcca tgatgaatga ggccccaggg    360
 cccatcaatt tcaccatgtt cctgaccatg tttggtgaga agttaaatgg cacagatcct    420
 gaagatgtca tcagaaacgc ctttgctctt gctttgatga agaagcaaca ggcaccattc    480
 aggaagatta cctaagagag ctgctgacaa ccatggggga tcggtttaca gatgaggaag    540
 tggatgagct gtacagagaa gcacctattg acaaaaaggg gaatttcaat tacatcgagt    600
 tcacacgcat cctgaaacat ggagccaaag acaaagatga ctgaaagaac tttagctaaa    660
 atcttccagt tacattgtct tactctcttt tacttctcag acacttcccc caccctcata    720
 gaacctgttg catgcaactt agtttcacag ctttgcctct tctttttgat gtatttattc    780
 cagacctttc tgccacttta gcacttggta taatcagact gggaaatggg ggatgagggt    840
 ggtaaattgt attgaaaaag atcgcgaata aaaatcaaca aagtgtgaaa gcccagaaaa    900
 atatattcgt atttcctggg ttttgctggg atttttacat ttttatataa taaaaatgtt    960
 attttgaaaa aaaaa                                                     975



      <210> 1966
      <211> 777
      <212> DNA
      <213> Homo sapiens


      <400> 1966
 agggtacaga gggcaagggg agctaacggt gctcaagccc acaccctaca tcctcacatc     60
 aaccccctga aggagtgtcc agcacagtcc acagcctccc tgggcgattc tgggttcctg    120
 gctgggccac ccagagccag gactgggctc caggtgcagc caaggtgctg tccctgcctc    180
 gatgtccccc attatcttcc ccagactaca acacggtgca gactgtgggc atgactctgg    240
 caaccatctt gttcctgctg ggtatcctca tcgtcatcag caagaaggtg aagtgcagga    300
 aggcggactc cagcccaacc tgcaaatcct gtaagtctga gcttccctct tcagcccctg    360
 gtggcggcgg cgtgtaacac cttcccgagg aaactccgct gccgaccctg cctgagcgcg    420
 ggagcctgag gaccgggtgg aggcggtggg gacccagccg cgcgccggga gcgctccccg    480
 gaatgagccg ccccacccac cccaaggctg gagccgctgc accctgctgt ccctctccag    540
 gccttggcaa tgacgatccc ccaaagagcc cgtctgcacc ccagacccag ggcctcaggc    600
 ctccagctcc tgggatccgg gagtccatcc cggcccagca cccccagcat ccccgtgtat    660
 ggcccccctg cacctccttg tctcatcccc gaagatccgt ccccctggcc cctcagtgtc    720
 catgtcttga gcttaataaa tgtgcatttg gttttttcct ttgaaaaaaa aaaaaaa       777



      <210> 1967
      <211> 612
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> misc_feature
      <222> (1)...(612)
      <223> n = a,t,c or g


      <400> 1967
 aacagacagt ggcatattca ccccggtcca aactcggaac actgctgcca gaatttccca     60
 atgtcaaaga tctaaatctg ccagccagcc tgcctgagga gaaggtttct acctttatta    120
 tgatgtacag aacacactgt cagagaatac tggacactgt aataagagcc aactttgatg    180
 aggttcaaag tttccttctg cacttttggc aaggaatgcc gccccacatg ctgcctgtgc    240
 tgggctcctc cacggtggtg aacattgtcg gcgtgtgtga ctccatcctc tacaaagcta    300
 tctccggggt gctgatgccc actgtgctgc aggcattacc tgacagctta acttaagtga    360
 ttcgaaagtt tgccaagcaa ctggatgagt ggctaaaagt ggctcttcac gacctcccag    420
 aaaacttgcg aaacatcaag gtcgaaatgt ccgagaaggg tcttccaaat ctgagacggc    480
 aaacatcact taatcatctc tggcaggcat cttcgaaaag tgattcacag tgcagacatc    540
 acgtttcaaa tgctggaaga ntgggagaac gtggacctgg acagcatcac caagccaacc    600
 ctttacaccc at                                                        612



      <210> 1968
      <211> 825
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> misc_feature
      <222> (1)...(825)
      <223> n = a,t,c or g


      <400> 1968
 ggtgctgcct gggctgggct ccagctcaca ccctccctaa aaggaaatgg gagaaaggac     60
 cggccaaaca agagggttaa ggttagagaa gggggacaca aatgtcttca ggcttaggtc    120
 cctgggggct cccagtcctg cccctgttcc tctactcaca tcccagctcc tcccagtttc    180
 ttttcggacc tcctcctctc cccttccttc tntattccag gctgggttgg gctctaagca    240
 aggggaggga ttagagcctc cttcctctct gcccctcccc atgggtctct agggggctgg    300
 tgcaggcagc agcagaggca ctctgggcag ctgggtgagg gcccatctgg gcaaggcccc    360
 cagcgcctgc cttctctccc ggggccctgt gggcaagcct cctgcttcac tttcaggttt    420
 ctcgaagtgc cttcttgctc ctgtctgttt ccccatcctg ccagatttct gtttctcttg    480
 ctgggctttt ggcagtaggg ggctgtgttg gtgggcccta cgaagatgct cagtgctcga    540
 gatcgccggg accggcaccc tgaggagggg gtagttgcag agctccaggg cttcgcggtg    600
 gacaaggcct tcctcacctc ccacaagggc atcctgctgg aaaccgagct ggtaacagct    660
 gcctcccaac ctggtgcctc catctccctg acccccggct cctggccagc cttatgccag    720
 cccccagctc acccttcagt agcctccttc cccaagccct ctggacacct ctcctgcccg    780
 cagctgcccc ttcttcgtct cctactctgc cttcttgctg cctca                    825



      <210> 1969
      <211> 621
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> misc_feature
      <222> (1)...(621)
      <223> n = a,t,c or g


      <400> 1969
 tcccgatatt cccgggtcga cgatttcgtc gccgagccca gctccgccgc cgagcgcctg     60
 tgccggcacg gctacaccat ggagcgcccg gataaggcgg cgctgaacgc actgcagcct    120
 cctgagttca gaaatgaaag ctcattagca tctacactga agacgctcct gttcttcaca    180
 gctttaatga tcactgttcc tattgggtta tatttcacaa ctaaatctta catatttgaa    240
 ggcgcccttg ggatgtccaa tagggacagc tatttttacg ctgctattgt tgcagtggtc    300
 gccgtccatg tggtgctggc cctctttgtg tatgtggcct ggaatgaagg ctcacgacag    360
 tggcgtgaag gcaaacagga ttaaagtgaa catcaccttt ttatagcatt aaattcattt    420
 tttaaaatga taaatgctgg agggggccat ctgatttgaa taaagttgaa agaacatgtt    480
 aaagtcagtc ttaaggagtc acgtttgagt atgtaaattt tgatctttct aatatgttgg    540
 ttgnaaaatc agttttaact gtatgaatct ganttgcnat gagaattgga aagtagtacn    600
 agaataggta attaatggcc a                                              621



      <210> 1970
      <211> 406
      <212> DNA
      <213> Homo sapiens


      <400> 1970
 ggaaagctga tgtgaaaaac ctttctggga aaaacagacc tgtgaattca aaaatacatg     60
 atatttttaa aggatgggct cttcaaccac ttgatccaga tggccgagta aaaatttggg    120
 tttatggcgt ttcaggtggc gcttttctca tcatgatttt cctaatattt acttcctacc    180
 ttgtttgcaa gaagccaaaa ccacatcaaa gcacacctcc ccaacagaag cctctgacct    240
 tatcctacga tggagactta gacatgtaat ctgaaaaaga aatccaaatg tagacatcaa    300
 ctgccttaac cgctttctct tttgtagctc tcagacttct cagttttttg aggaatctca    360
 agatgtgata tattgggcag aatacaaata ttgcaaaagt aatatt                   406



      <210> 1971
      <211> 1500
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> misc_feature
      <222> (1)...(1500)
      <223> n = a,t,c or g


      <400> 1971
 tcccgctctc ctcgggctcg ccgcccccgc cccgtgcccc ctcccccatc gcgagggccc     60
 cttccctccc ctccctgcgg gcgggcaatt caaacccgaa agggcgggaa ggcggcgctc    120
 ggggttggcg ggcgggggaa agcgctgccg ccaaaaaacc gccccctcgc ccacgttccc    180
 cgcgcacgag acgcgcgctg tcgccgccca cgagttcccc gggctgcgcg cgcctccctc    240
 tcccgccctc gacggctgcc atagcaacgg cgctgggctc cgcctccgga gggggtttgt    300
 ttgcgccatc tgcagctgtt gctcctgcct gtcgcggtgg tgcgggctcc gctgccctcc    360
 ccggctgcgc tccggtccag ccctcgcttc tcggggtcgg cgagccggag ctcctgcgcg    420
 cgcttcgttc ttatacgaac gtcgggctca ctcatttatg tcctagaaaa gttgtgtgga    480
 cgactgcttt aattttcatt tttagcactc taaagtttgg gaagtaatta agaaccacct    540
 caaaatctgc agttttttgt tcttgtttct tataggctga aggggatgct aagggagata    600
 aagcaaaggt gaaggacgaa gtaaggtcat tctctcttca agggtcaaag ccttgggact    660
 agcagaggcc actggactcg gtgattaacc gtaacctgtg tcctgaattt acactcctat    720
 aattttagag caaattgata ccaaactttc aaagcgactt acctgtccta tttctaactt    780
 tctcgttgtc tttaatagcc acagagaaga tccgcgaggt tngttttgct gttaagtgtt    840
 atggttttgg aatttttcgt ggttgttccc tgaaactaaa aaacatcaaa aaacaattcc    900
 ctttgcttcc atgaattatg gttagtgcct ggttttgaat cattgcctct acttgggact    960
 cttgcccctt tgggttttgc tggttctgaa atttctgatg cctgtagcca aagtgggaca   1020
 tttgagtggg cttctggaaa tccaacattc tagaagaaag gcccacccca caaaaacttt   1080
 tgaggaggag gagaaaactt ctcctacccc tggtaccttt tggttggttg tgggtggttt   1140
 tccttccagt cccattgtac ctgatgttcc acctttttcc ctcctccttc ctgcccaaaa   1200
 aaagaaaccc tgctccctcc caaagcccag agccccaagc ctaaaaaggc ccctgcaaag   1260
 aagggagaga aggtacccaa agggaaaaag ggaaaagctg atgctggcaa ggaggggaat   1320
 aaccctgcag aaaatggaga tgccaaaaca gcccaggcac agaaagctga aggtgctgga   1380
 gatgccaagt gaagtgtgtg catttttgat aactgtgtac ttctggtgac tgtacagttt   1440
 gaaatactat tttttatcaa gttttataaa aatgcagaat tttgtttttt aaaaaaaaaa   1500



      <210> 1972
      <211> 602
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> misc_feature
      <222> (1)...(602)
      <223> n = a,t,c or g


      <400> 1972
 aaactgttga gaaaacggaa ctactgggga aagggagggc tcactgagaa ccatcccggt     60
 aacccgatca ccgctggtca ccatgaacca cattgtgcaa accttctctc ctgtcaacag    120
 cggccagcct cccaactacg agatgctcaa ggaggagcag gaagtggcta tgctgggggc    180
 gccccacaac cctgctcccc cgacgtccac cgtgatccac atccgcagcg agacctccgt    240
 gcctgaccat gtcgtctggt ccctgttcaa caccctcttc atgaacacct gctgcctggg    300
 cttcatagca ttcgcctact ccgtgaagtc tagggacagg aagatggttg gcgacgtgac    360
 cggggcccag gcctatgcct ccaccgccaa gtgcctgaac atctgggccc tgattttggg    420
 catcttcatg accattctgc tcgtcatcat cccagtgttg gtcgtccagg cccagcgata    480
 gatcaggaag gcatcattga ggccaggagc tctgcccgtg acctgtatcc cacgtactct    540
 atcttccatc ntcgccctgc cccagaggcc aggantctgc ccttgactgn attcacttac    600
 tc                                                                   602



      <210> 1973
      <211> 1799
      <212> DNA
      <213> Homo sapiens


      <400> 1973
 gttaattttg gttccttaaa acgccccccc cctttttttt ttttttcctt cctttttttt     60
 ttttgcgaga cagggtctca ctttgtggct caggctggag tgtactggca cgttcttagc    120
 tcactgcagc cttgaactcc tgggctcagg caatcctcct accttagcct cctgagtagc    180
 taggactaca ggaatgtgcc atcatgcctg gctaattttt aagttttttg tagagatggg    240
 atctcactat gttgcccaag ctggtttcag attcctgtgc tcaagggatt ctgctaactt    300
 ggctccccaa agtgctggga ttacaaatgt gagccactgt atctggccca tattcttttt    360
 taagaaaaga tgcagaggtg ttaaatatta atatcaaatt gtccaggcat ggtgtttatg    420
 aaattgtgtg ccctctgaca ggcaaccaaa cacacacgac ttcatttctt tattaattcc    480
 tgcctcatca tcttttctca ttgatgctcc ttaatgtcaa aggaatctct ctctctcaca    540
 cacacataag accaaaacaa atatcttgaa catgcaaaaa aatagtctac gcttttgaat    600
 agtgtgcact gttgaatagt gtgcactgtt ggatagtgtg cactgttgaa gtgtgatgtg    660
 cctaaggcaa caggatcttg ggaaagctct agatttttgg cttcgaaata aaactgcatg    720
 ttgaatagca ggtttttaca tttattattg ttgtgtattt cctccccttt ttgcaatact    780
 atctacgctg agttatctat tgccaactag caccaattct ccaaatcaaa gtgtgtgagg    840
 aaaacacact cgtgcaatcc tctttaacag aagatacacc aagtaacctg tctgtctact    900
 tctgttaccc agaaataaaa gaacttgaag ggctgcttgg ctgggagggg gtcccgggtg    960
 gggaagaggc atcctgccct cagtcgggaa tccatggtga acagctggat gtcctgtgga   1020
 ttccagtaca gggccgactg gctgagttgt agacaagaga ccagacatag gggataaaaa   1080
 actcctcggg ctgctcctct tccacatatt tgaatttcaa ttctggaaat ttcttcagtc   1140
 tgtctttggg cagcgcaacg acgccttgct taatgatttc caggacccgt tccactgaca   1200
 gctcagctcc agcttgcagc aaccttgagc taaagaagga gatcaccaga tcaatatttt   1260
 gcattatatc ctgaaatgaa ggatgagttc gaaattgttc aaagagatcg cgtttgtaaa   1320
 gcagggcgta taccaagttt gggttgtggt gaagggaatt tgtcaggcag gagttgatga   1380
 tctctaacat cattcgaatc acttcttcaa tgacatttag gtcttgtgca taatctggta   1440
 gaggaacatc attagaactc agcgaacctc tcaaggactg tgtggcttgt tccagaactt   1500
 tgttgtgttt tttagacagc aaagaaaata aactgatgat cctctgggca gcatactgat   1560
 ggagagaacg aaactgtgcc gacatatttg ctaaagctgc caaacaattt gtgtcaaggt   1620
 acttgtctcg tgtcctagtc atgttgtatt gaatggttct tattaccacc aggatcagga   1680
 gactccccaa ggagatttca gttaaaactc gttctgaata ccaagtaata ttttttagta   1740
 tcacttcatg aatggatctg ttgaagccat catcttccgt aaggatcaac aatattata    1799



      <210> 1974
      <211> 449
      <212> DNA
      <213> Homo sapiens


      <400> 1974
 cagtgtggtg gaattcacgg tctgccacac cagggggcca tagtgccgac aggggagcag     60
 cctggggtgg cagcccaagg ccagctgctg tttgttttcc tctgatcctt gtggaaggcc    120
 caaaaggatc ttttgtgact ggcctaaaat ctgccaggct ggactgtgct gttcctctct    180
 gtcctggggc tcctggcctc ccgggctgtg tccgcactca gcagcctctt cgcggccgag    240
 gtcttcccca cggtgatcag gggggccggg ctgggcctgg tgctgggggc cgggttcctg    300
 ggccaggcag ccggccccct ggacaccctg cacggccggc agggcttctt cctgcaacaa    360
 gtcgtcttcg cctcccttgc tgtccttgcc ctgctgtgtg tcctgctgct gcctgagagc    420
 cgaagccggg ggctgcccca gtcactgca                                      449



      <210> 1975
      <211> 2083
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> misc_feature
      <222> (1)...(2083)
      <223> n = a,t,c or g


      <400> 1975
 ggaattccca ggacccacag cggctgcaaa ggaaacctaa aggcaatact agctccattt     60
 caagaaccga acaggaaata ttccaagtag aattaaacct tcaaaatgct tctctgaatc    120
 atcaagggat tgacaaaata tatgactgcc aaggtttact gccacctcca gagaagctca    180
 ctgccgaggt cctaggaatc atttgcattg tcctgatggc cactgtgtta aaaacaatag    240
 ttcttattcc tttcctggag cagaacaatt cttccccgaa tacaagaacg cagaaagcac    300
 gtcattgtgg ccattgtcct gaggagtgga ttacatattc caacagttgt tactacattg    360
 gtaaggaaag aagaacttgg gaagaaagag tttgctggcc tgtgcttcga agaactcttc    420
 tagtctgctt tctatagata atgaggaaga aatggtatgt gtggggactt cccagttggc    480
 tgtaagttgc catttgaact aaacgaaata gatcaggaac tgaggacata tctaaatttt    540
 ctagttttat agaaggcttt tatccacaag aatcaagatc ttccctctct gagcaggaat    600
 cctttgtgca ttgaagactt tagattcctc tctgcggtag acgtgcactt ataagtattt    660
 gatggggtgg attcgtggtc ggaggtctcg acacagctgg gagatgagtg aatttcataa    720
 ttataacttg gatctgaaga agagtgattt ttcaacacga tggcaaaagc aaagatgtcc    780
 agtagtcaaa agcaaatgta gagaaaatgc atctccattt tttttctgct gcttcatcgc    840
 tgtagccatg ggaatccgtt tcattattat ggtagcaata tggagtgctg tattcctaaa    900
 ctcattattc aaccaagaag ttcaaattcc cttgaccgaa agttactgtg gcccatgtcc    960
 taaaaactgg atatgttaca aaaataactg ctaccaattt tttgatgaga gtaaaaactg   1020
 gtatgagagc caggcttctt gtatgtctca aaatgccagc cttctgaaag tatacagcaa   1080
 agaggaccag gatttactta aactggtgaa gtcatatcat tggatgggac tagtacacat   1140
 tccaacaaat ggatcttggc agtgggaaga tggctccatt ctctcaccca acctactaac   1200
 aataattgaa atgcagaagg gagactgtgc actctatgcc tcgagcttta aaggctatat   1260
 agaaaactgt tcaactccaa atacatacat ctgcatgcaa aggactgtgt aaagatgatc   1320
 aaccatctca ataaaagcca ggaacagaga agagattaca ccagcggtaa cactgccaac   1380
 cgagactaaa ggaaacaaac aaaaacagga caaaatgacc aaagactgtc agatttctta   1440
 gactccacag gaccaaacca tagaacaatt tcactgcaaa catgcatgat tctccaagac   1500
 aaaagaagag agatcctaaa ggcaattcag atatccccaa ggctgcctct cccaccacaa   1560
 gcccagagtg gatgggctgg gggaggggtg ctgttttaat ttctaaaggt aggaccaaca   1620
 cccaggggat cagtgaagga agagaaggcc agcagatcag tgagagtgca accccaccct   1680
 ccacaggaaa ttgcctcatg ggcagggcca cagcagagag acacagcatg ggcagtgcct   1740
 tccctgcctg tgggggtcat gctgccactt ttaatgggtc ctccacccaa cggggtcagg   1800
 gaggtggtgc tgccccagtg ggccatgatt atcttaaagg cattattctc cagccttaag   1860
 atcttaggac gtttcctttg ctatgatttg tacttgcttg agtcccatga ctgtttctct   1920
 tcctctcttt cttccttttg gaatagtaat atccatccta tgtttgtccc actattgtat   1980
 tttggaagca cataacttgt ttggtttcac aggttcacag ttaagaagga attttgcctc   2040
 tgaataaata gaatcttgag tctcatgccc aanaaaaaaa aaa                     2083



      <210> 1976
      <211> 641
      <212> DNA
      <213> Homo sapiens


      <400> 1976
 attacgccaa gcttggcacg aggctactgc cctcactgga cttggggggt ctggaccttt     60
 ggcccctgcc ccctggggga cccagacctc tgggccctca cttctggccc ttacagagat    120
 ccaggcatcc aacaccccca tccctgccca agcgtctgag gtgttagtgg tggggggaga    180
 agcccaccat cccagactct ggtaaatgtc tttgctggtt ccttgcagct ggcagtgggg    240
 gggaccccag cccaggccca ggcctaggcc tggggtgggg atagggtcag atgaagaatt    300
 cctctttcct cttgtgtccg tcgctgccat tgaggaaggc ttctcttgct tctccctgtt    360
 catccaagcc actggcttcg tgggtcagat aggaaccctt ctgccgtacc gagcaccaga    420
 ccatgcccac tagcacacat atgatcagaa acaccagcag cgccaggatg ccgcccacaa    480
 tggcataggg aaccgacgtc tgagcctcta ccaccgcacc agggtcgtag accacaagta    540
 cgtagagcgc cctcgcatgg ccgtgcttat tggacgcctc gcaagtgtag gtgccgttat    600
 ccgcggatac cagacccggg agcgtgagcc gctctcccac g                        641



      <210> 1977
      <211> 703
      <212> DNA
      <213> Homo sapiens


      <400> 1977
 tgaagtacca actattactt gcaattctta atgatgaact atatcattct aaattggatg     60
 attgcctctg agttggaagt cctccatttc tctttccaca tgagtagtag cattcacatt    120
 tgctgttact ttatcacttg cttcaacaaa agaacaagtt aatttatttt atgtttctta    180
 atgctgctgt aatgttttta attgtttttc tttgtcatta cagacctggg cattacattc    240
 tctatcattg atcattgatt ctgctggccc actctattat gtgcatgtgg aacctaccct    300
 ttctcttatt ataatagttg tggtaaatgt gcctcctact catgctgaag ttcaccaaag    360
 ccttggtcgc tgtttgaatg cccttattac cacgttaggt ccagagctac aaggtaacag    420
 tacttcaatt tctaccttaa ggacttcctg tctactgggt tgtgcagtaa tgcaagataa    480
 cccagactgc cttgttcaag ctcaggccat ctcttgcctt cagcagcttc atatgtttgc    540
 tccacgacat gtcaacttgt ctagcctggt tagctgcctc tgtgtgaatc tttgtagccc    600
 ctacttgtta ctgagaagag cagtactggc ttgcttacgt cagcttgtac aaagagaagc    660
 agctgaagtt tcagaacatg ctgttatgct tgctaaggat agc                      703



      <210> 1978
      <211> 1280
      <212> DNA
      <213> Homo sapiens


      <400> 1978
 gcaatttttt gaccatctcc actggaagac agagaatggc ttcagggccg ggcacttgtg     60
 tcttcctgag tttcatgttc cccaatccta ccattggtat gtagtaggta ctcagagctt    120
 ttttactgaa tgagtcaact ggtgagtaat aaagaaagca ggaaggagtg gctgagtgaa    180
 gaaatctgga aagaaggaag ggagggaaaa caccaggtag gaaatgagtg aacgatggaa    240
 gaggagaggg aattcaacaa ggacctcctc tttggcttca ggagctgggg accctgaacc    300
 agacctgtgg atcatccagc cccaggaatt ggtgttgggg accactggag acactgtctt    360
 tctgaactgc acagtgcttg gagacggtcc ccctggaccc atcaggtggt tccagggagc    420
 tggtctgagc cgggaggcca tttacaactt tggaggcatc tcccacccca aggcgacagc    480
 ggtgcaggcc tccaacaatg acttcagcat tcttctgcaa aacgtctcca gtgaggatgc    540
 aggcacctat tactgtgtaa agtttcagag gaaacccaac aggcaatacc tgtctggaca    600
 gggcaccagc ctgaaagtga aagcaaaatc tacctcttcc aaagaggcag aattcaccag    660
 tgaacctgca actgagatgt ctccaacagg cctcctggtt gtgttcgcac ctgtggtcct    720
 ggggctgaag gcaattacct tggctgcact cctactggcc ctggctacct ctcggaggag    780
 ccctgggcaa gaagatgtca agaccacagg cccagcagga gccatgaaca ccttatcatg    840
 gagcaagggt caagagtgag gggtcagccc cagagtgagg accctctgag ttggagagga    900
 gccagggctc ctcaaccatt tccctacctc cagtcccagc ctctaggtgc ccccaggcct    960
 catgacaaac tcctagatcc ctacatctgg ttttggtcca cctagtgaaa ttcccttctt   1020
 tgcaccgggc ttccctctaa aatgtctccc tttctctttt tggcctgttc aagacctcct   1080
 tgcttttcag tccctggctc agtctctcct caacaccctt gcccctgctg cagccctttc   1140
 tggtgcgccc tgcccctttc cccacctcgc tacatccttc ttggcctcca acatccaact   1200
 cagagtcttc ttcccaggag atgtctgtaa gaatctctga actcaaccag ccagaccatc   1260
 tgtgcccctc catttacacc                                               1280



      <210> 1979
      <211> 492
      <212> DNA
      <213> Homo sapiens


      <400> 1979
 aaaatcaaag caaagaatct cacaaactat gatctctgca gcatttttct tggaacctct     60
 acgctcttgg tttgggttgg agtcatcaga tacctgggtt atttccaggc atataatgtg    120
 ctgattttaa caatgcaggc ctcactgcca aaagttcttc ggttttgtgc ttgtgctggt    180
 atgatttatc tgggttacac attctgtggc tggattgtct taggaccata ccatgacaag    240
 tttgaaaatc tgaacacagt tgctgagtgt ctgttttctc tggtcaacgg tgatgacatg    300
 tttgcaacct ttgcccaaat ccagcagaag agcatcttgg tgtggctgtt cagtcgtctg    360
 tatttatatt ccttcatcag cctttttata tatatgattc tcagtctttt tattgcactt    420
 attacagatt cttatgacac cattaagaaa ttccaacaga atgggtttcc tgaaacggat    480
 ttgcaggaat tc                                                        492



      <210> 1980
      <211> 496
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> misc_feature
      <222> (1)...(496)
      <223> n = a,t,c or g


      <400> 1980
 agagcgggnn nnnnnnnaat tgatnactga ntaactttcg agagnggcgg aattcctccg     60
 gcggctgtcc gtggcggtag gagttggctg cgggatgtgc tcagccggtt agctgctgcg    120
 gggcggcgac ggcggggaac gcgacgagga cggggacgcg ctggcggagc gggaggcggc    180
 agggaccgag tgggatcccg gcgcgagccc gcggcggcgc ggacagcggc cgaaggagag    240
 cgagcagtca gaggaaaatg ttaactactg aagaatggtc aaagaggtgc agtactgcta    300
 gctttgaaga tgaaagaaga ggagccaagg aatgtgggca gctctagcaa ctggaaaaga    360
 tgttgaagac tcacagaacc acactggtga gccggttgga gatgactaca agaaaatggg    420
 aacacttttt ggtgaactga acaaaaacct tatcaacatg ggcttcacaa ggatgtattt    480
 tggagaacga atagtg                                                    496



      <210> 1981
      <211> 508
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> misc_feature
      <222> (1)...(508)
      <223> n = a,t,c or g


      <400> 1981
 ngaagagatg gggnnnnnaa attgaatnat tgtaccaccg tggcggaagn cgctgcccga     60
 gccctcagcc gggctgccct ccagcctaca ccgggacggt cctggagcag acgctgagcc    120
 ctctgtggga tgaactcctg gtatttgagc agttgatcgt ggatgggagg agggagcacc    180
 tgcaggagga gcctccatta gtgatcatca atgtatttga ccacaataag tttggccccc    240
 ccgtgttcct gggcagggca ctggccgccc caagggtaaa gctgatggag gacccatacc    300
 aacgcccaga gttgcagttc ttccccctga ggaagggacc ctgggcagcc ggagagctca    360
 ttgccgcctt tcaactcatt gaactagact acagtggccg acttgaggtc agcatgccct    420
 ggcgtggcta gcacaggctg tgagcccaac ttgttagtcc atcaggccat ccagccctag    480
 ggaatataaa acatggatat gtcccagg                                       508



      <210> 1982
      <211> 2562
      <212> DNA
      <213> Homo sapiens


      <400> 1982
 tttttttttt ttttacaaat ccaagtaaca actttattgt agtatacagc acaattttta     60
 catacatatt agtggttttg acagtgttac ttttgagtag accttaaatg aatccacaaa    120
 gttaatatat taaaaataaa atatacacag taaaacaaca ggcatccaga tgttcagaat    180
 catgcagata ggagtggttt ggttggtgtt atcactgggt accttgccta tttaactcgc    240
 cagcaaatac cacttcttct gtttctcatt cccatataat tcatcaaaat cagagagttc    300
 taaacatata caaaataaac ctcttttaaa gccacatcag taaaaaattt caattaataa    360
 ggttatcatc aaaccaagaa ttccactgat catttgatca gcccattact aggaaacagg    420
 caatatcagc acccgatcta aaggcaagcc tatttcattt attaaaacac caacaagaga    480
 gattaatcaa caaagcaact attaacaaca tgttaatctt aatataagac actgagagaa    540
 aagtaaaaat aatacataaa tatcactcca ctgagccagg atataactca tggactacag    600
 atacatgagt ttcctacctg tcaaacaatg cctttaaaaa atttttttag gaaaaaaaaa    660
 aaaaacacaa tatatgagaa gatgcaaagg aaaggcagaa atgtgaattt atgcatctag    720
 ttccacaatt taaaataaat atcaaactga caatataaag ctaagtgaca atgacttaac    780
 cattgggcac caaacaggca atacaactgc tcactgtaat acataatgct cttcaggagt    840
 ttccagcaga tggccatcac aacaatactg tcataataca gaaaaaacat ttatccactg    900
 tggaaagaga ccctgaagag aatgtggcaa aggcatagag aaaaagttgg atcttttgaa    960
 aaagttaatg atatcaaaat acttttccat cactggtaaa ccaagctagg tcaagtatat   1020
 gtcccaaagc agcactgaat tcagagtaag aggttggcag aaaagtttgg aaaactgcag   1080
 tttttaaaaa ttggcaattt ctccatgctt aataaaacta tcagaagagg tataatgttt   1140
 gtgcgtttgt ggaatgttga ctgcttgctg caaaaattta caacatgaat gaggacctgc   1200
 agagatgcat atcaatgaaa tattttttta aaaatttaca aaaaactaaa gtttctattt   1260
 aaaaaagaac catgttatgc caagatgaaa catggtaaaa agtagtgtaa gttctgtcca   1320
 tgattcttta cctagtgaat gggaaagtaa tagaaacaat tttcttctta aaaaggaagg   1380
 tttgttattg cactgacttt tacaacctga catagtaatt tagaaaaatc atgtagtaaa   1440
 atctgtaaaa ttaaaatata aaagtctggt ttgtaaacat cagttggcca agtctattca   1500
 gagtccttca tgatagtgga atggaatgaa taattaattc actaccttat ttatttgctg   1560
 tgaggcagaa aattccagaa cacagccttt atactttcac agtaattata ttcaaaagat   1620
 ataaagtcag tgcagttatt ttttttcttt ccctgtgcaa tgtttagctc tcaccccact   1680
 cccaagtgcc ataattgaaa taatactggt ttggagaatt agtacagatt ggtcataaat   1740
 gccgcataaa gtccgtagga cttcggtaaa ggtatttcca aatggcgtag taatgcactg   1800
 cagctgccgt ggccacaaac aggtgccaga tggcgtgggc aaatggaatg atgccatcac   1860
 tcttgaagaa cacaactccc aagcaataaa ttaagccccc acaggcaagt tcctgaagtc   1920
 catcggtgtt gttcattgat gtcaccacca aggctggaga gaatcccatt gtgagataga   1980
 aaaagagttc aaccccctta tatttttcat ggtagagaaa tacataaatg gttcctccag   2040
 ctgccatgag ccagataaac caacgcatat gagatgccag gggtccaagt tcacgaagat   2100
 ttaaccatgg agcataagaa gcagcaatga agaaatagat aaccattcta tcacacatgt   2160
 gaaaacaatg ctccactgtc cttaagtggc tctttttcca tgatacaatg tgaaatactg   2220
 tagaaacgat gaagagggca cagagtccca ttccataaat ccatgctgtt atcttttccc   2280
 agcagtcatc agacagccga tggaggaggg cactgcccac gatggccgga acaatgagga   2340
 atgcgtgtgt gtaacagtta gcagcatgtt catagcaagt tggcttgtag cggccattgg   2400
 ctggagctcg atggttcatg aaccgctgga atcgattctt gaaccgcatt gatcctctgc   2460
 tcctcctcgg gggccaggag ctccgtctcg tcagcaccgg cggccgggcg cgcggccctc   2520
 atgggcttgg gctgctccgg aggccgcctg cgtgtccagc gg                      2562



      <210> 1983
      <211> 595
      <212> DNA
      <213> Homo sapiens


      <400> 1983
 ttttttatca gttaatagta tttattatta tttgtggtca ccaatgccaa ttaaaacaat     60
 aattaaatag aacatgatga aataattcaa tggtaggaaa aaaaaaaatc tggcctacaa    120
 gtgaacatgg aaagtaaaag taaatattta gaaagtgaaa tcaggagtgg aaaaaagctc    180
 cagcatctca ccatggggtc ttccaaagcc agcagtactg gagatgttta ttgttcaaag    240
 atggacttgc ttgggttggg attctccaac tagagccaga ggggagattc tctgcttccc    300
 gttccgacca aagggtaaat gaacccagca cctatgctgg cccggacatc actgataggt    360
 aagatgaagt cacttggcac accttttttg tcaggttggt gagacagaga aagatcggtc    420
 tttgccatgc agatgggcaa atttccaaaa ccctgtaaga aaggaaagaa aatgtgttca    480
 ctgatataga tgtgagtctc ctgtgttttt caatttgcac tttatacagt ctcggcagca    540
 atggtatgcc agctcagatc gaggcacatg caggagctgc ttgttactac ttgtt         595



      <210> 1984
      <211> 2076
      <212> DNA
      <213> Homo sapiens


      <400> 1984
 atgaagccat gtgctcattc ttggaacgca gagctgtcaa gaaacatcat cagacatagt     60
 tttaacctgg taatggtggc tgccagtcag gtggctgtca gtcagctcct tggttcttat    120
 gaaattcttc tgctggtttc catagagttg atgttctgtt ttggtctggg gtatttcttt    180
 ataccaatgc aagaatggcc taacacatat ggagaaaggg tctttgtaga tgtggaatca    240
 tcagtattta aatggaatca taagtgtcta cataagacag aggcagagag agattacaca    300
 aagaagagat taaagttatg tggccacaag ccagggaatg ctgttggcca acagaagctg    360
 gaagaagcaa gaaaccgatt ctttactaga gcccctggag ggagtgcagc cctgccgaca    420
 cttcgatttc agcccagtga taccgatttc agacttctag cctccagaac tattttaacc    480
 tttgagacca agaacccgtc ggaattagca gaacgtttgc gctctgtttg tgggaatcag    540
 agcaatgcct atgcccggct gctggaatac cgcctgaatg ccttgcgagg actgtggaat    600
 gcccagcgcc agctggcctt agaagaacag catgaaaggg aaagttcagg tgatgaggaa    660
 actttggccc tgctcaaacg ccagggcttg ttgcagcaac ctgagcaagc gcccttcaca    720
 tcgaggatgg ggctcctgct ggtcttcccc cttattcagt cccagagtag aacagacccc    780
 tctctctgta acataactgc tgaggtgcta ttgaactgcc ttcgtgactg ccagcctttg    840
 agcttgacca aggagcctgc tgactgtctc aatggaattg aaactttgct gtgctcttgg    900
 ctagaggaga cttctgacac aggccgacac atcccacata agcaaaaaga aaatgctgct    960
 gctgccctgg tggctttggc ttgtgccaga ggttttgtgt actgccggaa cgaggagttg   1020
 gaaccaggat gggtggcttt tggcagcggc agtcttctcc accggcctgt ctctttcgat   1080
 aataaacctc actccctttt ccaggtcatt gaccagaaca cccttcaggt gtgccaggtg   1140
 gtgccaatgc cagccaatca cctccccatt ggcagcacca tgagcactgt gcacctgtct   1200
 tcagatggca cttacttcta ttggatctgg tctcctgcca gcctgaatga gaaaacaccg   1260
 aagggacatt ctgtcttcat ggacattttt gaacttgtga cgctgaaagg aaagaaggcc   1320
 aaggggaaga aggtggcccc ggcccctgct gttgtgaaga agcaggaggc caagaaagtg   1380
 gtgaattccc tgtttgagaa aaggcgacat ccagcccaaa agagaactca cctactttgt   1440
 gaaatggccc gctatgtcag gttgcagcag cagagagcca tcctctataa gcagctgaaa   1500
 gtgcctcctg ctattaacca gttcacccag gccctgaact gccaaacagt tactcaactg   1560
 cttaagctgg cccacaaata cagaccagag acaaagcaag agaagaagca gaggctgttg   1620
 gcccaggctg agaagaaagc tgctggcaaa gggggcgtcc ccactaagag accacctgcc   1680
 cttcgagcag gagttaacac catcaccacc ttggtggaga acaagaaagc tcagctggtg   1740
 gtgattgcac acgatgtgga ttccatcgag ctggttgtct tcttgcctgc cctgtgttgt   1800
 aaaatgggag tcccttactg cattatcaag gggaaggcaa gactgggccg tctagtccac   1860
 aggaagacct gcaccactgt cgccttcaca caggtgaact tggaagacaa aggcgctttg   1920
 gctaagctgg tggaaggtat caggaccaat gacaatgaca gatacgatga gatctgctgt   1980
 cactggggag gcaatatctt gggtcccaag tctgtggctt gcattgccaa gctcgaaaag   2040
 gcaaaggcta aagaacttgc cactaaactg ggttaa                             2076



      <210> 1985
      <211> 2321
      <212> DNA
      <213> Homo sapiens


      <400> 1985
 tctagcctgg atgacagagc aagactccat ctcattaaat aaataaataa ataaatattc     60
 aacaacttaa gaaatggggt aagtagttct tatctgttgt ttgcttaaga gtatgagaat    120
 catcgatcct catgctattg ctgatctgaa ttgcttttaa ctttttcttt cagattaaga    180
 atgacccaaa ataaattaaa gctttgttcc aaagccaatg tgtatactga agtgcctgat    240
 ggaggatggg gctgggcggt agctgtttca tttttcttcg ttgaagtctt cacctacggc    300
 atcatcaaga catttggtgt cttctttaat gacttaatgg acagttttaa tgaatccaat    360
 agcaggatct catggataat ctcaatctgt gtgtttgtct taacattttc agctcccctc    420
 gccacagtcc tgagcaatcg tttcggacac cgtctggtag tgatgttggg ggggctactt    480
 gtcagcaccg ggatggtggc cgcctccttc tcacaagagg tttctcatat gtacgtcgcc    540
 atcggcatca tctctggtct gggatactgc tttagttttc tcccaactgt aaccatccta    600
 tcacaatatt ttggcaaaag acgttccata gtcactgcag ttgcttccac aggagaatgt    660
 ttcgctgtgt ttgctttcgc accagcaatc atggctctga aggagcgcat tggctggaga    720
 tacagcctcc tcttcgtggg cctactacag ttaaacattg tcatcttcgg agcactgctc    780
 agacccatct ttatcagagg accagcgtca ccgaaaatag tcatccagga aaatcggaaa    840
 gaagcgcagt atatgcttga aaatgagaaa acacgaacct caatagactc cattgactca    900
 ggagtagaac taactacctc acctaaaaat gtgcctactc acactaacct ggaactggag    960
 ccgaaggccg acatgcagca ggtcctggtg aagaccagcc ccaggccaag cgaaaagaaa   1020
 gccccgctat tagacttctc cattttgaaa gagaaaagtt ttatttgtta tgcattattt   1080
 ggtctctttg caacactggg attctttgca ccttccttgt acatcattcc tctgggcatt   1140
 agtctgggca ttgaccagga ccgcgctgct tttttattat ctacgatggc cattgcagaa   1200
 gttttcggaa ggatcggagc tggttttgtc ctcaacaggg agcccattcg taagatttac   1260
 attgagctca tctgcgtcat cttattgact gtgtctctgt ttgcctttac ttttgctact   1320
 gaattctggg gtctaatgtc atgcagcata ttttttgggt ttatggttgg aacaatagga   1380
 gggactcaca ttccactgct tgctgaggat gatgtcgtgg gcattgcaga agatgtcttc   1440
 tgcagctggg gtctacatct tcattcagag catagcagga ctggctggac cgccccttgc   1500
 aggtttgttg gtggaccaaa gtaagatcta cagcagggcc ttctactcct gcgcagctgg   1560
 catggccctg gctgctgtgt gcctcgccct ggtgagaccg tgtaagatgg gactgtgcca   1620
 gcatcatcac tcaggtgaaa caaaggtagt gagccatcgt gggaagactt tacaggacat   1680
 acctgaagac tttctggaaa tggatcttgc aaaaaatgag cacagagttc acgtgcaaat   1740
 ggagccggta tgacacactt tcttacaaca acagccactg tgttggctgg agagggatgg   1800
 ggtgggccca acggggacac aaggaggcag aggagctaac ccctctactc cactttcaaa   1860
 actacatttt aaagggaatg tgtatgtgaa gagcactacc aaacatcgct tttgttttgt   1920
 tttgttttgt tttaagcttt tttttttttg cttgttttta aagccaaaac aaaaaacaac   1980
 caagcactct tccatatata aatctggctg tattcagtag caatacaaga gatatgtaga   2040
 aagactcttt ggttcacatt ccgatattaa aatagtgaca tgaactggca aagtggtttt   2100
 aaaagctttc acgtgggata aatgattttc tttttttctt ttctttcttc ctatggtctt   2160
 gtctgaataa actactctcc tgaataaaac aacatccaac ccaggtcatt gaaatgaaat   2220
 tggccagtca aaaaaaaaaa aggggggggc cctttaaaaa aaaaaaattt taacccccgg   2280
 gggggggaaa gaaatttttt ttttttgggg cccccaaaaa t                       2321



      <210> 1986
      <211> 541
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> misc_feature
      <222> (1)...(541)
      <223> n = a,t,c or g


      <400> 1986
 ccgcctcggg ccgcagagct tgccccctcc ccacccgcag acatgttcga gtccaagaac     60
 ggccccgagt atgcttcgtt tttccccgtc atgggcgcct cggccgccat ggtcttcagc    120
 gccctgggcc ctgcctatgg cacaaccaag agcggtaccg gcatttcggc catgtctgtc    180
 attcggccgg agcagatcat gaagtccatc atcccagtgg tcatggctgg catcatcgcc    240
 atttccggcc tggtggtggc agtcctcatc gccaactccc tagagtgctc tgtgtatgcg    300
 gatgatttag aaatgtcatt tctctttcct cggatgttta tttataaaga tctggcctgt    360
 tcctgcgtct ccggaacggc ccttgtttcc cagctattta taaccttagt tagagggtcc    420
 ccctgtgggt tcctgttgtt tagacttcct ggatggaacc gccctccccg ccgggcccgt    480
 ggccctgcac ggaactgtgt cccccaaagt ttttggatgt gnnnnnnnnn nnnnnnnnnn    540
 n                                                                    541



      <210> 1987
      <211> 456
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> misc_feature
      <222> (1)...(456)
      <223> n = a,t,c or g


      <400> 1987
 cccacgcgtc cggcttcgtg gtccagggct ccaatggcga gtttcctttc ctgaccagca     60
 gtgagcgcct cgaggtggtg agccgtgtgc gccaggccat gcccatgaac aggctcctgc    120
 tagctggctc cggatgcgag tccactcaag ccacagtgga gatgaccgtc agcatggccc    180
 aggtcggggc tgacgcggcc atggtggtga ccccttgcta ctatcgtggc cgcatgagca    240
 gtgcggccct cattcaccac tacaccaagg ttgctgatct ctctccaatc cctgtggtgc    300
 tgtacagtgt cccagccaac acagggctgg acctgcctgt ggatgcagtg gtcacgcttt    360
 cccagcaccc gaatattgtg ggcatgaagg acagcggtgg tgatgtgacc aggattgggc    420
 tgattgttca caagacccag gaagcangat tttagg                              456



      <210> 1988
      <211> 1224
      <212> DNA
      <213> Homo sapiens


      <400> 1988
 ggtttttttt ttttttcttt tgggaaaggc attggccact ttggacttta ttagcaacag     60
 taatgtcccc tgacatacgc acaagcttgt agctccacgg ccaggtcttc ccccaacctc    120
 acaatggccc cgtgatgcag gcaggcaggc gagtgggggt ctcccctcct tatccacagg    180
 gccaccgaaa ggcccacgag acggccttgc ccgaggtcac ccagcggagt ggcttgctgg    240
 gagccctggg aataacagtc ccacacaagg ctctctccct ccgcagctgg acctgtacgc    300
 gggggctctg tttgtgcaca tctgcctggg ctggaacttc tacctctcca ccatcctcac    360
 gctcggcatc acagccctgt acaccatcgc aggtatggtg cctgcagcag ggaggtccac    420
 ccaggggacg tgtaaagggg tcagaaggcc acctccccct acaggcccga gggagcagcc    480
 caggaagtgg ccccagcagg agccccagaa gttcctcccc gtgtccctcc tccctggggc    540
 cagggccccc tccagcaacc ttgcttccac tggcaggggg cctggctgct gtaatctaca    600
 cggacgccct gcagacgctc atcatggtgg tgggggctgt catcctgaca atcaaaggtg    660
 aggacagagt ctgtggccat ggcggggctg tccccacagc gagccctttg gagtctggca    720
 ctgcccggca ctgtgcagga ttcatgccgt tggggttctg ggtagcatcg ctgggagtgg    780
 gtgggttcag gaggttgagc cactaggcag tcagcccccc tgctggcccc tcagggactg    840
 ccctggctgg tagaggctac ccaccctgct gccccgctgt taccagctct ggccctggca    900
 aggagctgac tcaggaactc agggccagcc acacccgcat tggctcagcg cttgatggtg    960
 aggtggggct gtaggcgggt gtgaaggcac acaaccagga ggccataaaa ctgcctgggc   1020
 agctcctcca attgtttaaa agcatgtaca aaatgccaag aggtgatgct acctcctgca   1080
 ggacaaaggc cagggaggaa agaagagagc tgggagagat tggcgatact agtctggaac   1140
 agataggaaa ctcacagggc tgcccggaga gagcgtgagc tcaccgtccc tggaagtatg   1200
 taagcagagc caggagctcg tgcc                                          1224



      <210> 1989
      <211> 1128
      <212> DNA
      <213> Homo sapiens


      <400> 1989
 tacaacaggg caatgtttca tccccacgct gtcaataaga ttgcattaag cttgaacaac     60
 aagaatcccc agatcaaaag tcttgttttt agaactgttg gcagccgttt gtcttgtaag    120
 aggcgggcat aaattatttt atctagcatt tgataacttt aaagaggttt gtggagaaaa    180
 acagcgcttt gagaagttga tggaacattt caggaatgaa gacaataaca tagattttat    240
 ggtggcttct atgcagttta ttaatattgt agtccattca gtagaagata tgaatttcag    300
 agttcacctg cagtatgaat ttaccaaatt aggcctggac gaatacttgg acaagctgaa    360
 acacactgag agtgacaagc tttcaagtcc agatccaggc ttacctggac aatgtttttg    420
 atgtaggagc tctactggaa gatgctgaaa ctaagaatgc tgccttggag agggtggaag    480
 aactggaaga aaacatttct catttatctg aaaaactgca agacacagag aatgaagcca    540
 tgtccaagat tgtggaactg gaaaagcaac tcatgcagag gaacaaggag ctggatgtcg    600
 ttcgggaaat ctacaaagat gcaaatactc aagttcacac attaagaaaa atggtcaaag    660
 aaaaagaaga agcaattcaa agacagtcta ccctggaaaa aaagattcat gagctagaga    720
 aacaagggac cattaaaatt cagaagaaag gggatgggga tatcgccata ctgccagttg    780
 tggcttctgg cacattgtcc atggggtcag aagtggtagc aggtaactct gtgggaccca    840
 caatgggggc cgcttcctca ggacccttgc cccctcctcc accaccactg cctccctcat    900
 cagacacacc tgaaacagtg caaaatggtc cagtaacacc acctatgcca ccgccgccga    960
 cgccccctcc tccacctcct cctccaccac cgccccctcc gcctcctcct ctcccaggcc   1020
 ctgcagctga gactgtacca gctcctccct tagcacctcc ccttccctct gcacctccgc   1080
 tgcctggaac atcttcaccc acagtggttt tcaactcagg attagcag                1128



      <210> 1990
      <211> 1816
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> misc_feature
      <222> (1)...(1816)
      <223> n = a,t,c or g


      <400> 1990
 agagggagca ggccnnnnna atgagnaatg angtatatac acagngcggn ggaattctgc     60
 caagaagaat gtaagttctc caacatcttc aaataaagaa gtggttatga ggaatgatca    120
 gaataatgga gatatgaaac cattccagaa tttcacaaca ataccaatca cacaggctct    180
 caactacaat ctgagcaaag aagggcattt agaaaaagaa ccttggaatg cattcagcca    240
 tcatggccca gttaatgtct ccatcaatgg aattccttgc attctcttct gggccaaaag    300
 aataatgatt aaatttaaga atcaaacctg gctggacctt acagacgagc catttggtca    360
 gaaggtaact gtggaccctg acaactcaaa ttgcagtgaa gaaagtgcta ggttgtcttt    420
 gaagcttggt gatgctggaa accccagaag tcttgctata agattcatcc ttaccaatta    480
 caacaagttg tccatccaga gttggtttag tttgcgccga gtcgagatca tttccaacaa    540
 ttcaatccaa gcagtcttta acccaactgg cgtatatgct ccctctggtt actcctaccg    600
 ctgccaacgc gtgggcagcc tgcagcagga ccaggccctc ttgctgccca gcgacacgga    660
 tgatgggtcg agcctgtggg aggtcacttt tattgatttc cagatccaag gttttgccat    720
 caagggggga cgatttacca aagcccaaga ctgcgcctcc tccttctcgc cagcttttct    780
 gatcggcctg gcaatgtccc tgatcctgct gctggtgttg gcctatgccc tgcacatgct    840
 catctacctg cggtatctgg accaacaata tgatctcatc gcctctcctg cccacttctc    900
 gcagctgaaa gctcgagaca cagccgaaga gaaggagctg ctgaggagcc agggggctga    960
 atgctataaa ctgagaagcc aacagatcag caaaatctat gtttagcagc acaggctggc   1020
 ccccaccatg tccacagtgg gctccgaaag ttgtctctgt tctgtgctat ttgacttgtg   1080
 aattacagat tttcaccgaa tggcttgatt acaaaaaaaa agaaaaaacg cagaaaggaa   1140
 atagataatg aattcttttt gaaccatcca ctggcctact taggtagact tggggcaatc   1200
 aaaaaaggca tctcagggat cccacagaga caaatatgcc tgttagttgc ctcaaagtac   1260
 cctgaaagca aaggggtatt tcaagtacgg agaaagagag agagagaaga agaaggagga   1320
 ggaggaggag gaggagaagg agaaggagga gcaggaggaa gaggaggagg aggaggaaag   1380
 ggagggaggg agggagaggg agagagagag aaagattggc aacacagaga aggggaaaac   1440
 acacttggtc ctccttgcct gtgccagttt ggatgtgaca attatagaaa taataaacca   1500
 agattatctg gaagttcata atttaaacta ttttgtaaca taatttgcat ttctagatat   1560
 tatgtcccaa ttttgtttta aaaacagtct ttttctcttt catagaaatg ttgagggagg   1620
 actcaacatg tggcagagca ctttatttaa ggaccttctt gtcctttact gtgctgttca   1680
 gaagcagtac agctccatct gtgaagtagg ggtaatagtc atggccatat tttacctttc   1740
 catttgggaa ggggccaggg ttgtctcact tgtctgattt agacctccat gagctctcat   1800
 aggtccactt ggaata                                                   1816



      <210> 1991
      <211> 1658
      <212> DNA
      <213> Homo sapiens


      <400> 1991
 tttttttttt ttggctgcac cagtgtattt tcccatccaa aacatacaca ggggaggctt     60
 gatgccaccc caggaaacag aataacccct tctagggact tcttagcaga gactgatctc    120
 catctgcccg caagggctgg gtgtccaatt tgtcctgctt cccagagctg catggtgggt    180
 agaggagtaa gtggaacata agaacaggct tgcatgactg tgtttatttg aaccaccaga    240
 tctgttccaa taaagagctc tccagaccct gcctcacctt acagggaagg gcttagagtc    300
 agggaagagg ggcctgttgc tcctgtccct gaaaaaggag gtcaagatgg agcccgggct    360
 tcctggtgac cattcagact cctcccactg cttgtccctg tggaggacac aggacgggct    420
 accccatctc aggtttgggg tgggatcgct cacagtcacc cccggaacag ccccaactga    480
 gggtgggggg cctggccctg gacacctcat gtctctgggc cgggaagcca cgatccctca    540
 tccatcaggc ctgctgccgc tctccacccc agcgggggat ggacatctgt gctccctcgc    600
 agtacactgc ggacccagga ggtcccctgc atgacattcc tctccttggc ctcaggccag    660
 caggcggctg tactctgcca gagcagagga ctttctcacc ccatcccaga tccgggcagc    720
 gtagtggaac cagttcttct cggtgaggat cgtgtgtgac agctgtggcc gggccatgga    780
 catcacttgg ctccggagct tgctcaccaa ggactggaaa ctggggtggc cacgataccc    840
 aggcagcagg gagaagagtg ggctggaacc aggtcctgct cttggtgggt tttcactctc    900
 tgcttcactg tccatgaagg gtaccaggaa taagttgacc tcagagtcca ggaagtcagg    960
 tggaagcccc gggaagacat tgcattgtaa catggacaga gttcccttgt aacgcaggtg   1020
 ggagtgggcc atgagctggt caatcatcag gtgcatctgc cgcagcttcc gaggacagaa   1080
 gtcctctcgg cgagctttgt tctgcaagaa gactaggtgg gggtagtact cggtgccttc   1140
 atcggagccc gatgagctgc tggactcgtg gctgggggat ggggtggagg gcttcaccat   1200
 ctctgctgtc tgcaggaacc tgtagagact gaggtctgtg aaccagtcct ggacaacaat   1260
 caccacatgg cagaccgtga aaaggaaggc agcaatctgg agtgactgca tttcaacgta   1320
 agtgtgggga aggttgtact ctggaggcag tttgcggtca ttattgatga gatggtctag   1380
 gatagaaggg ctcaggatgg gctgtgtgtc caggaaaaca atccgttctt gggtaataaa   1440
 gaagtcgatg ccactggtct ggttgccccc tcgttccttc atttcagcgc tctgggcccg   1500
 gaaaacataa gtcctctggt cctcctctgg agtgttggct gacaacaatg acatgaccat   1560
 ggacttgcct gtcccctgga ggcccaggac accaaccacc aacacatcag tctgatccaa   1620
 caggtactcg atgccactgt cacgaattcc acgtctgg                           1658



      <210> 1992
      <211> 646
      <212> DNA
      <213> Homo sapiens


      <400> 1992
 gatcaagatt cggagtttgg gctgcctaat agctgcaatg atactgttgt cctcactcac     60
 cgcgcacccc atcttgaggc ttatcatcac catggagata tccttcttca gcttcttcat    120
 cttactgtac agctttgcca ttcatagata catacccttc atcctgtggc ccattcctga    180
 cctcttcaac gacctgattg cttgtgcgtt ccttgtggga gccgtggtct ttgctgtgag    240
 aagtcggcga tccatgaatc tccactactt acttgctgtg atccttattg gtgcggctgg    300
 agtttttgct tttatcgatg tgtgtcttca aagaaaccac ttcagaggca agaaggccaa    360
 aaagcatatg ctggttcctc ctccaggaaa ggaaaaagga ccccagcagg gcaagggacc    420
 agaacccgcc aagccaccag aacctggcaa gccaccaggg ccagcaaagg gaaagaaatg    480
 acttggagga ggctcctggt gtctgaaacg gcagtgtatt ttacagcaat atgtttccac    540
 tctcttcctt gtcttctttc tggaatggtt ttcttttcca ttttcattac cacctttgct    600
 tggaaaagaa tggattaatg gattctaaaa gcctaaaaaa aaaaaa                   646



      <210> 1993
      <211> 1530
      <212> DNA
      <213> Homo sapiens


      <400> 1993
 atggcaataa ccttgcggga gctgaatggc ctgagctatg aagagatagc cgctatcatg     60
 gattgtccgg cgttgacgat agcgggatac tggataaggg tattaggcat gcagaaagaa    120
 caactttccg ctttaatgga tggcgaaacg ctggatagtg agctgcttaa cgaactggct    180
 cataacccag aaatgcagaa aacctgggaa agctatcact taatccgtga ctcaatgcgg    240
 ggtgatactc ccgaggtgct ccatttcgat atctcttcac gcgtgatggc cgccattgaa    300
 gaagagccag tgttcttgcg tgatattata tgcgagtata actgcgcgtc gatcccatat    360
 gaacgtgatc gcataatgca aagtgtcaca aagatcgtta atgctcaact catccggatc    420
 gagcttgcgg gaaagcatac cattgatgta ctgatggaac ggctatctgt tcgaattgcg    480
 ctgataaaaa aattactgcg tctttttttc ccgctctcgc tgcgggtacg ttttctgttg    540
 gcaacggcag cggtagtact ggtgctttcg cttgcatacg gaatggtcgc gctgatcggt    600
 tatagcgtca gtttcgataa aactacgttt cggctgttac gtggcgagag caatctgttc    660
 tatacccttg cgaagtggga aaacaataag ttgcatgtcg agttacccga aaatatcgac    720
 aagcaaagcc ccaccatgac gctaatttat gatgagaacg ggcagctttt atgggcgcaa    780
 cgtgacatga aaggatggac gaacgaatgc atcctcgtac tgagtggaga tcattcgata    840
 cagcaacagt tgcaggaagt gcgggaagat gatgacgacg cggagatgac ccactcggtg    900
 gcagtaaacg tctacccggc aacatcgcgg atgccaaaat taaccattgt ggtggtggat    960
 accattccgg tggagctaaa aagttcctat atgggtttgt gtgggcagcc cacaaataaa   1020
 gacgtccttc gccggatgaa gaagcgctac cccacgacgt tcgttatggt ggtcatgttg   1080
 gcgagctatt tccttatctc catgtttgga ggagtcatgg tctttgtgtt tggcattact   1140
 tttcctttgc tgtgtatgga aaaaattgta tctacaaagg caattcttga caaaaacaca   1200
 aatcagtgca aaggtatgtg taagggcatc cgtaccctga aatcttgcct atgctatctg   1260
 attaatggtt cttccattgt ggaggtccag gactcctggc tgatgggtgc tatcaagttc   1320
 caacaggaaa gcagactttt acaccacaga cttttaagtg ctattagaat taaacagaag   1380
 gaggaggaag aaaggaacaa gaaggagaag aaagacaaag agctggagag catatttccc   1440
 agctatggcc cttttcacta ctttaaaagc aaaaccatca aagaatgggc acctttctat   1500
 gggtatgact tttatcccct tgtcctctag                                    1530



      <210> 1994
      <211> 1268
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> misc_feature
      <222> (1)...(1268)
      <223> n = a,t,c or g


      <400> 1994
 acccgttacg acccacgcgt ccgccgagat cgctgtggca caagtgatcc ttatgtgaaa     60
 tttaagctga atgggaagac gctgtacaaa agtaaagtca tatataagaa cttgaaccca    120
 gtatgggatg agatagttgt attgccaatc caaagccttg atcaaaagct acgtgtgaag    180
 gtatatgatc gagatttaac cacatctgat ttcatgggtt ctgcatttgt cattctcagt    240
 gatcttgagc ttaacagaac aactgaacat attttaaaac tggaagatcc aaacagttta    300
 gaagatgaca tgggagtgat cgtcttaaat ttgaacctag tggtaaaaca gggtgatttc    360
 aagagacacc gttggtcaaa tcggaagcga ttaagtgcca gcaagtcctc tttgatacgc    420
 aacctacggc tctctgagtc cttgaaaaag aaccaactct ggaacgggat tataagtata    480
 actttgttgg aagggaagaa tgtctcagga ggaagcatga cagagatgtt tgtccagtta    540
 aaactgggag atcagaggta taaaagtaag acactgtgta agagtgcaaa tccgcagtgg    600
 caggaacagt ttgactttca ctacttctct gacaggatgg gcattttgga cattgaagtg    660
 tggggaaagg acaacaaaaa gcatgaggaa cgtctgggca cgtgtaaagt ggatatctcg    720
 gcactccctc tgaagcaagc caactgcctg gagctgccac tggacagctg tctgggggct    780
 ctccttatgt tggtcacact tacaccctgt gcgggggtct ccgtctctga tctgtgtgtc    840
 tgccccttag cagacctcag cgaaagaaag cagattaccc agcgatattg cttacagaac    900
 tccctgaaag atgtgaaaga cgtcggcatt ctacaagtga aggttttaaa ggcagcagat    960
 ctcttagcgg cagatttctc agggaagagt gacccatttt gcttgttgga gttaggcaat   1020
 gaccgacttc agacgcatac cgtctacaaa aacctcaacc ctgaatggaa caaagttttt   1080
 acatttccca ttaaagatat ccatgatgtt ttggaagtga cagtgtttga tgaagatgga   1140
 gataaannnn nnnnnnnnnn nnnnnnnnnn nnnaaanaan naanaaaaan nnaaannnnn   1200
 nnnnnnnnnn nnnnnnnnnn ngggcggcct tttaaaaaaa aacaattttt ttggcgcggg   1260
 gtggggga                                                            1268



      <210> 1995
      <211> 1735
      <212> DNA
      <213> Homo sapiens


      <400> 1995
 tttttttttt ccttggtgga aatttttttg gtgttttttg tgctctgttg caagctgatt     60
 cctagattaa tggcctccca gcagatttga aaggaaacct ggaagacttc ttattttgct    120
 gtgccttctg cttcctggtc ttgtgtaaag tcccaattca ctctcaattt gatccagctc    180
 tgactggtca agtagttcaa aagtcatcac cttcttcagt gtctgtgtcc tcttctggga    240
 tgggggcagc ctgagaaagt gcttgctgca caccctctaa ctggtctttg atagctgcaa    300
 gtcactgcag cttgtggata acatccccag ccagggtttg cttcatcagg tgaaaaggtt    360
 ttgggtcact ggttcagagg aaaggggtga gacccagctg ctggattgcg tcttctttgc    420
 ttgggtcttg tgaccactgt ccaacttgtt ccttctttct cttgagctca gtggggcaaa    480
 ccaagggtta aatttcatct tcatcatttg gttcccatgc catttttcta gagatggaaa    540
 atctgaaaga tctctagaga aaacttcctc actgggtcgg tcaagatcat cagaagtgtc    600
 tgtctgtgga gtgtatcctt ctgaaaggtt gaaggtccca ttatcagtcc aggatacctc    660
 tgagacgtct gtgtcagaca cagataactc tttggcagca accgtgaggc taatcttagg    720
 acaaagagct gaaaagtcta attcactgtc atctttgtga cttttttctt tgtctgcttc    780
 agatctctca cgtttcttct gattaatata ttctccaatt ccaaaatcca gtttcagcag    840
 aactgactta attttgctgt aaattttttg tccaatatca ttacatttaa acaatggaca    900
 caaaaatgca acacagtaaa cagtagatag ctgagtataa cccccaggaa tggtaacttc    960
 cccaagatcg taaaaaaatg tgcaacaaca cttacaagac ccaggaagac aaaaacttgc   1020
 ccagggctct gctgtttaaa aagagacatt tcttgaagaa atatgctgaa attcatccat   1080
 gattctgcaa taccagtggc tgagccctgg gtctttcatc tggtttggaa ttgataactt   1140
 cccagccttt cactgaggct tctccacaac tgtgcacctc ttgttctaga caaaaccata   1200
 tcctttatta tttgcataat aacacgccca agtatcatga cggaaatcag gtgatatact   1260
 ctccatggag tcaatgcaag gaaccagaac agcaggttgg cagcgacgaa gccgagcagc   1320
 gtccgcagcg gcctcttcca gctcagcagc tcgtcggcgc ggcagcccag ccacagcgac   1380
 cggctccccg agcagccagg ttaccgcggc cgccgcccgg cccgcggcct cctccacctg   1440
 caaccccgcg ccctccgccg ccccagcttc ctgcgcttcc tcctcctgct gctgccgctc   1500
 tgcgggggat gcctggggcg gtggcggcga cggcggcgcc tgctcctcgg cggcaggagc   1560
 cgggcatccc tcctcggcgt gctccggagg cgccgggctc gccatcttca gctgtgcttc   1620
 caggcaggga cggggccggg cgcgcgcgcg ggcgcgcctg ggtgtgggtg ccgccgaggg   1680
 cggggcggcg gtggcggcag gtcccggagc ggggcgcgca ccgcggggca caggc        1735



      <210> 1996
      <211> 1735
      <212> DNA
      <213> Homo sapiens


      <400> 1996
 tttttttttt ccttggtgga aatttttttg gtgttttttg tgctctgttg caagctgatt     60
 cctagattaa tggcctccca gcagatttga aaggaaacct ggaagacttc ttattttgct    120
 gtgccttctg cttcctggtc ttgtgtaaag tcccaattca ctctcaattt gatccagctc    180
 tgactggtca agtagttcaa aagtcatcac cttcttcagt gtctgtgtcc tcttctggga    240
 tgggggcagc ctgagaaagt gcttgctgca caccctctaa ctggtctttg atagctgcaa    300
 gtcactgcag cttgtggata acatccccag ccagggtttg cttcatcagg tgaaaaggtt    360
 ttgggtcact ggttcagagg aaaggggtga gacccagctg ctggattgcg tcttctttgc    420
 ttgggtcttg tgaccactgt ccaacttgtt ccttctttct cttgagctca gtggggcaaa    480
 ccaagggtta aatttcatct tcatcatttg gttcccatgc catttttcta gagatggaaa    540
 atctgaaaga tctctagaga aaacttcctc actgggtcgg tcaagatcat cagaagtgtc    600
 tgtctgtgga gtgtatcctt ctgaaaggtt gaaggtccca ttatcagtcc aggatacctc    660
 tgagacgtct gtgtcagaca cagataactc tttggcagca accgtgaggc taatcttagg    720
 acaaagagct gaaaagtcta attcactgtc atctttgtga cttttttctt tgtctgcttc    780
 agatctctca cgtttcttct gattaatata ttctccaatt ccaaaatcca gtttcagcag    840
 aactgactta attttgctgt aaattttttg tccaatatca ttacatttaa acaatggaca    900
 caaaaatgca acacagtaaa cagtagatag ctgagtataa cccccaggaa tggtaacttc    960
 cccaagatcg taaaaaaatg tgcaacaaca cttacaagac ccaggaagac aaaaacttgc   1020
 ccagggctct gctgtttaaa aagagacatt tcttgaagaa atatgctgaa attcatccat   1080
 gattctgcaa taccagtggc tgagccctgg gtctttcatc tggtttggaa ttgataactt   1140
 cccagccttt cactgaggct tctccacaac tgtgcacctc ttgttctaga caaaaccata   1200
 tcctttatta tttgcataat aacacgccca agtatcatga cggaaatcag gtgatatact   1260
 ctccatggag tcaatgcaag gaaccagaac agcaggttgg cagcgacgaa gccgagcagc   1320
 gtccgcagcg gcctcttcca gctcagcagc tcgtcggcgc ggcagcccag ccacagcgac   1380
 cggctccccg agcagccagg ttaccgcggc cgccgcccgg cccgcggcct cctccacctg   1440
 caaccccgcg ccctccgccg ccccagcttc ctgcgcttcc tcctcctgct gctgccgctc   1500
 tgcgggggat gcctggggcg gtggcggcga cggcggcgcc tgctcctcgg cggcaggagc   1560
 cgggcatccc tcctcggcgt gctccggagg cgccgggctc gccatcttca gctgtgcttc   1620
 caggcaggga cggggccggg cgcgcgcgcg ggcgcgcctg ggtgtgggtg ccgccgaggg   1680
 cggggcggcg gtggcggcag gtcccggagc ggggcgcgca ccgcggggca caggc        1735



      <210> 1997
      <211> 376
      <212> DNA
      <213> Homo sapiens


      <400> 1997
 ggaggtctca ctgagcaccg tcccagcatc cggacaccac agcggccctt cgctccacgc     60
 agaaaaccac acttctcaaa ccttcactca acacttcctt ccccaaagcc agaagatgca    120
 caaggaggaa catgaggtgg ctgtgctggg ggcacccccc agcaccatcc ttccaaggtc    180
 caccgtgatc aacatccaca gcgagacctc cgtgcccgac catgtcgtct ggtccctgtt    240
 caacaccctc ttcttgaact ggtgctgtct gggcttcata gcattcgcct actccgtgaa    300
 gtctatggac aggaagatgg ttggcgacgt gaccggggcc caggcctatg cctccaccgc    360
 caagtgcctg aacatt                                                    376



      <210> 1998
      <211> 1617
      <212> DNA
      <213> Homo sapiens


      <400> 1998
 atgaagaatg gtgtccagtg ggcagagctg gctggccacg actacgtgtt agacctggtg     60
 tcggacctgg agctgctcag ggacttccct cgacagaagt cctacttcat tgtgggcaca    120
 gaggggcctg cagccagcag gggaggcccc aaagtggtgt ttgggaacag ctgggactcg    180
 gatgaggaca tgtccactag accccagccc caggagcaca tgcccaaagt acttgactct    240
 gatgggtaca gcagccacaa tcaggacggt acaaatgggg agactgaggc ccaaagaggg    300
 acagcaaccc accaaggtca accaacaatg gctgctgtct ctgagtcaga cagtcttgga    360
 gagcctgctg tgccccacaa ggggctggac tgctacctgg atagcctctt cgaccctgtg    420
 ctgtcctacg gggatgcgga cctggagaag ccaacagcca ttgcctaccg catgaaaggg    480
 ggaggccagc ccggtggagg cagcagtagt ggtactgaag acacccccag gagaccccca    540
 gagccaaagc caatcccagg cctggatgcc tccacattgg ctctgcagca agccttcatc    600
 cacaaacagg ccgtgctgct ggcccgggag atgaccctgc aggccacggc actccagcag    660
 cagcccctga gtgctgccct gagatccttg cccgcagaga aacccccagc accagaggca    720
 cagccgacgt ctgtaggcac cggtccccct gccaaacccg tgctcctgcg tgccactcca    780
 aagcccttgc gcccagcccc tctggccaag gctccaagga tccccatcaa gcctgtggct    840
 gcccctgttc tagctcagga tcaggcttct ccagaaacca gcctgcaccg ggatgcagcc    900
 actgtcacac agatgcactt cttgaccggc cagggccgcc tcctgtccct gcttgatgac    960
 agcagtctgc atctctggga gattgtccac cataatggct gtgcccacct ggaagaagca   1020
 ctcagtttcc agctgcccag ccggcccggc tttgatggtg ccagtgctcc gctcagcctt   1080
 acccgagtca cagtggtcct gctggtggct gccggcgaca tagcagccct gggcactgag   1140
 ggcagcagtg tcttcttcct ggatgttacc accctgaccc tgctcgaggg gcagacgctt   1200
 gccccaggcg aggttctgcg cagcgtgcca gacgactacc gctgtgggaa ggcactgggc   1260
 cccgtggagt cactccaggg acacctgcgg gaccccacaa agattctcat tggctacagc   1320
 cggggcctgc tggtcatctg gaaccaggcc tcgcagtgtg tggaccacat cttcctgggg   1380
 aaccagcagc tggagagcct atgctggggg cgtgatagca gcactgtggt cagctcacac   1440
 agcgatggca gctatgctgt ctggtctgtg gatgccggca gcttcccaac gctgcagccc   1500
 acggtagcca ccacacctta cggcagggca tgtacacccg ttgcccacga tcacatcgat   1560
 gaactcgtcc ggggagcagt cttctcggaa aagcacttct gcattgaaga tctctga      1617



      <210> 1999
      <211> 794
      <212> DNA
      <213> Homo sapiens


      <400> 1999
 cggatagtct tcgaacaaga ccacgccaag cttggcacga gggcggggac gcggcgggac     60
 agcgacatgg ccggccacac tcagcagccg agcgggcgcg ggaaccccag gcctgcgccc    120
 tcgccctccc cagtcccagg gaccgtcccc ggcgcctcgg agcgggtggc gctcaagaag    180
 gagatcgggc tgctgagcgc ctgcaccatc atcatcggga acatcatcgg ctcgggcatc    240
 ttcatctcgc ccaagggggt cctggagcac tcaggctccg tgggtctggc cctgttcgtc    300
 tgggtcctgg gtgggggcgt gacggctctg ggctccctct gctatgcaga gctgggagtc    360
 gccatcccca agtctggcgg ggactacgcc tacgtcacag agatcttcgg gggcctggct    420
 ggctttctgc tgctctggag cgccgtcctc atcatgtacc ccaccagcct tgctgtcatc    480
 tccatgacct tctccaacta cgtgctgcag cccgtgttcc ccaactgcat cccccccacc    540
 acagcctccc gggtgctgtc catggcctgc ctgatgctcc tgacatgggt gaacagctcc    600
 agtgtgcgct gggccacgcg catccaggac atgttcacag gcgggaagct gctggccttg    660
 tccctcatca tcggcgtggg ccttctccag atcttccaag gacacttcga ggagctgagg    720
 cccagcaatg cctttgcttt ctggatgacg ccctccgtgg gacacctggc cctggccttc    780
 ctccagggct cctt                                                      794



      <210> 2000
      <211> 978
      <212> DNA
      <213> Homo sapiens


      <400> 2000
 gtgattacag gcatgagcca tcgcacctgg ccatgaaggc ttttagatgg gtctggagct     60
 tggaggagaa gtctgaacta aggataaact aaagagaggc caatgagact tgaaccctga    120
 gcctaagttg tcaccagcag gactgatgtg cacacagaag gaatgaagta tggatgtgaa    180
 agaacgcagg ccttactgct ccctgaccaa gagcagacga gagaaggaac ggcgctacac    240
 aaattcctcc gcagacaatg aggagtgccg ggtacccaca cagaagtcct acagttccag    300
 cgagacattg aaagcttttg atcatgattc ctcgcggctg ctttacggca acagagtgaa    360
 ggatttggtt cacagagaag cagacgagtt cactagacaa ggacagaatt ttaccctaag    420
 gcagttagga gtttgtgaac cagcaactcg aagaggactg gcattttgtg cggaaatggg    480
 gctccctcac agaggttact ctatcagtgc agggtcagat gctgatactg aaaatgaagc    540
 agtgatgtcc ccagagcatg ccatgagact ttggggcagg ggggtcaaat caggccgcag    600
 ctcctgcctg tcaagtcggt ccaactcagc cctcaccctg acagatacgg agcacgaaaa    660
 caagtccgac agtgagaatg gtaagttttc tttttggctt tataatgttg gcattcagtg    720
 cttctgtctg ttttggttga ctccgcgggg gggggatgtt tttctttctc tctttcctct    780
 catccttctt tctctctctt tcttgtccat ttctttttgt tttaatgtag tagaactcaa    840
 gaaatgtcct tgaataatgc attttttcct ggaaaaaaaa atcaatattt gacatcagat    900
 tgttaaatta ggcaagcagt ctacaatgtt ttggctatag ttttgaaaaa caggttaatc    960
 atctacagaa aaaaaaaa                                                  978



      <210> 2001
      <211> 954
      <212> DNA
      <213> Homo sapiens


      <400> 2001
 tttttttttt ttcctgaatg acacccataa cagctttatt ttcaaaggcg ggatccctcc     60
 ccgggcttgt gatgggacgg cgctgtgggc ccgagcagca gagccgtgca ggacaggcat    120
 gggcaggggt ggggcagctg gcccgggagg ccggcaggtc ccagaagaca cctcacacgg    180
 gttccatctg cagctcctcc ccgtccacag cctcaatctg gtggaaggca gcgtgggagc    240
 cgatgaccac cagggtggct cccagcaccc agaagacggc cgagcccgca ccagccagcc    300
 agaagaaggg gaaggagatg cctccagcca gagcatactg atgcgctggg ctcacctctc    360
 ggccaaagag cacaagcttg gactccaagg tgcgcagata gagaatgtaa caggcgccga    420
 aaaagacagc cagagccacc agcaacatag gggacgtcac cacacagtac aggatgaggc    480
 ccaggaacac gaacacatag ttgctctggt agtactccac gttgcgtacg aggcgctggc    540
 acagctctcc caggttgcgg ggccgtgaga agcgctgctg gtccacgaag gtgctccagg    600
 gccggatggt cgcgcggcgc cgctccagcc actcccggcc tgcaccggag ggaatcagct    660
 tcggcagcag ggtcgtgccg ctcagccctt ccgcctcggc atctttctgc tggtccttct    720
 gcgctgccat gtttgcgtcg tgaggggtag agctgctgta accagcccgg taccctgaag    780
 accccgccgg ccccgcccga cgccggcccc acccagcgga gtcgacgtgg cgcagccccg    840
 gagcagctgg ggactgtagt tctgccgccg agtattgtgg gagttgtagt cctgacggtg    900
 actaagagga tgggcgctat atggcgggtt ttacggcctt catcagggtc caat          954



      <210> 2002
      <211> 4461
      <212> DNA
      <213> Homo sapiens


      <400> 2002
 gcgaccgtcg ggatcccggg gccgcgcgct cagcttcacc cgacttactt caacctggcc     60
 gaggccgagg atttggccac cgccacctgc ggggagaggg gacccggcga ggggaggccc    120
 cagcccgagc tctactgcaa gttggtcggg ggccccaccg ccccaggcag cggccacacc    180
 atccagggcc agttctgtga ctattgcaat tctgaagacc ccaggaaagc acatcctgtc    240
 accaatgcca tcgatggatc tgaacgttgg tggcaaagcc ctcccctgtc ctcaggcaca    300
 cagtacaaca gagtcaacct caccttggat ctggggcagc tcttccatgt ggcctatatt    360
 ttaatcaaat ttgcaaattc tcctcgccct gatctttggg tcttggaaag atctgtagac    420
 tttggaagca cctactcacc atggcaatat tttgctcatt ctaaagtaga ctgtttaaaa    480
 gaatttgggc gggaggcaaa tatggctgtc acccgggatg atgatgtact ttgtgttact    540
 gaatattccc gtattgtacc tttggaaaat ggtgaggttg tggtgtcctt gataaacggt    600
 cgtccaggtg caaaaaattt tactttctct cacaccctga ggggagttta ccaaggcaac    660
 aaacatccgc ttgcgtttct tagaaccaat acgcttcttg gacacctcat ctccaaaagc    720
 ccagcgagat caactgtcaa ctcgccggta ttattacagc ataaaaggac acagccattg    780
 gtgggcagtg tgtttgcaat ggccatgctg aagtgtgcaa tataaacaat cctgaaaaac    840
 tgtttcggtg tgaatgccag caccacacct gtggggagac gtgtgatcgc tgctgcacag    900
 ggtacaatca gaggcgctgg cggcccgccg cttgggagca gagccacgag tgtgaagcat    960
 gcaactgcca cggccatgcc agcaactgtt actatgatcc agatgttgag cggcagcagg   1020
 caagcttgaa tacccagggc atctatgctg gtggaggggt ctgcattaac tgtcagcaca   1080
 acacagctgg agtaaactgt gaacagtgtg ctaagggcta ttaccgccct tatggggttc   1140
 cagtggatgc ccctgatggc tgcatcccct gcagctgtga ccctgagcat gcggatggct   1200
 gtgaacaggg ttcaggccgc tgtcactgca agccaaattt ccacggagac aactgtgaga   1260
 agtgtgcaat tggatacaat ttcccatttt gcttgagaat tcccattttt cctgtttcta   1320
 caccaagttc agaagatcca gtagctggag atataaaagg gtgtgactgt aatctggaag   1380
 gtgttctccc tgaaatatgt gatgcccacg gacggtgcct gtgccgccct ggggttgagg   1440
 gccctcgatg tgatacctgc cgctctggtt tctactcatt ccctatttgc caagcctgct   1500
 ggtgttcagc ccttggatcc taccagatgc cctgcagctc agtgactgga cagtgtgaat   1560
 gtcggccagg agttacagga cagcggtgtg acaggtgtct ctcaggagct tatgatttcc   1620
 cccactgcca aggttccagc agtgcttgtg acccagctgg taccatcaac tggaatttgg   1680
 ggtattgcca atgcaagctt catgttgaag gtcctacttg tagccgctgc aaactcttat   1740
 attggaatct ggacaaagaa aaccccagtg gatgttcaga atgcaagtgc cataaggggg   1800
 gaacagtgag tggaactgga gagtgtaggc agggagatgg tgactgtcac tgcaagtccc   1860
 atgtgggtgg cgattcctgc gacacctgtg aagatggata ttttgctttg gaaaagagca   1920
 attactttgg gtgtcaaggg tgtcagtgtg acattggtgg ggcattgtcc tccatgtgca   1980
 gtgggccctc gggagtgtgc cagtgccgag agcatgtcgt gggaaaggtg tgccagcggc   2040
 ctgaaaacaa ctactatttc ccagatttgc atcatatgaa gtatgagatt gaagacggca   2100
 gcacacctaa tgggagagac cttcgatttg gatttgatcc gctggcattt cctgagttta   2160
 gctggagagg atatgcccaa atggcctcag tacagaatga tgtaagaata acattgaatg   2220
 tagggaagtc aagtggctcc ttgtttcgtg ttattctgag atacgttaac cctggaactg   2280
 aagcagtatc tggccatata actatttatc catcctgggg tgctgctcaa agcaaagaga   2340
 tcatcttcct gccgagtaag gagccagcct ttgtcactct ccctggaaat ggttttgcag   2400
 acccattttc aatcacacca ggaatgtggg ttgcttgtat taaggcagaa ggagtccttc   2460
 tggattacct ggtgctgctc cccagggact actatgaagc ctctgatctg cagctgccag   2520
 tcacagaacc atgtgcctac gcaggacctc cccaagaaaa ttgcttactc taccagcatt   2580
 tgccagtgac cagattcccc tgtacccgtt cttgtgaggc cagacacttc ctgcttgatg   2640
 gggagccaag acccgtggca gtgaggcagc ccacacctgc acaccctgtc atggtggacc   2700
 tcagcgggag agaggtggaa ttgcatctgc gcgtgcgcat cccacaggtt ggaccctacg   2760
 tggttgtggt cgagtattcc acggaggcag cccagctgtt tgtggttgat gcgaatgtga   2820
 agagctccgg gtctgttctg gcaggccagg tgaacattta cagctgcaac tacagtgttc   2880
 tctgccggag tgctgtgatt gatcacatga gccgcatcgc catgtatgag ctattaacag   2940
 atgcagacat tcagctcaag ggacacatgg cccgattcct tctgcatcaa gtttgtatca   3000
 tacctattga agaatactca gctgagtatg tgagaccaca agtccactgc attgccagtt   3060
 atgggcgatt tgtcaatcaa agtgccacct gtgtctcctt ggcccatgaa actcctccaa   3120
 cagcattaat tttggatgtt ctaagtggca ggcccttccc tcacctgccc cagcagtcgt   3180
 caccttctgt tgatgttctt cctggggtca ccttgaaggc accgcagaat caagtgaccc   3240
 tgagaggacg tgtaccacac ctgggccgat acgtctttgt catccatttt taccaagcag   3300
 cgcacccgac gtttcccgcg caggtgtcgg tggatggcgg gtggccacgg gcaggctcct   3360
 tccatgcctc tttttgcccc catgtgcttg gctgccggga tcaagtgatt gtttaaggcc   3420
 agattgagtt tgacatctca gagcctgaag tggccgcaac tgtgaaggtt ccagaaggaa   3480
 agtccttggt tttggtccgt gttctagtgg tgcctgcaga aaactatgac taccaaatac   3540
 ttcacaaaaa atccatggac aagtcactcg agtttatcac caattgtgga aaaaacagct   3600
 tttaccttga cccccagaca gcctccagat tctgtaagaa ttccgccagg tccctggtgg   3660
 ccttttacca caagggcgcc ctgccttgtg agtgccaccc cactggggcc accggccctc   3720
 actgcagccc tgagggtggg cagtgcccat gccagcccaa cgtcatcggg cggcagtgca   3780
 cccgctgtgc aacaggccac ctacggattc ccacgctgca agcccaagcc gtgcagctgt   3840
 ggtcggcgcc tttgtgaaga gatgacgggg cagtgccgct gccctccccg cacggtcagg   3900
 ccccagtgtg aggtgtgtga gacacactca ttcagcctcc accccatggc cggctgcgaa   3960
 ggctgcaact gttccaggag gggcaccatc gaggctgcca tgccgagatg tgaccgggac   4020
 agcgggcagt gcggatgcaa gcccagaatc acagggcggc agtgtgaccg atgtgcttcc   4080
 gggttttacg gctttcctga gtgtgttccc tgcaattgca acagagatgg gactgagcca   4140
 ggagtgtgtg acccagggac cggggcttgc ctctgcaagg aaaatgtaga aggcacagag   4200
 tgtaatgtgt gtcgagaagg ctcattccat ttggacccag ccaatctcaa gggttgtacc   4260
 agctgtttct gttttggagt aaataatcaa tgtcacagct cacataagcg aaggactaag   4320
 tttgtggata tgctgggctg gcacctggag acagcagaca gagtggacat ccctgtctct   4380
 ttcaacccag gcagcaacag tatggtggcg gatctccagg agctgcctgc aaccatccac   4440
 agcgcgtcct gggtcgcacc c                                             4461



      <210> 2003
      <211> 647
      <212> DNA
      <213> Homo sapiens


      <400> 2003
 gaattcccgg gtcgacgatt tcgtgcggag ggcgaggagg agcagaggag cacacagatg     60
 aagcaggtgt ccacgcgtcc ggccgtccat ccgtccgtcc ctcctggggc cggcgctgac    120
 catgcccagc ggctgccgct gcctgcatct cgtgtgcctg ttgtgcattc tgggggctcc    180
 cggtcagcct gtccgagccg atgactgcag ctcccactgt gacctggccc acggctgctg    240
 tgcacctgac ggctcctgca ggtgtgaccc gggctgggag gggctgcact gtgagcgctg    300
 tgtgaggatg cctggctgcc agcacggtac ctgccaccag ccatggcagt gcatctgcca    360
 cagtggctgg gcaggcaagt tctgtgacaa agatgaacat atctgtacca cgcagtcccc    420
 ctgccagaat ggaggccagt gcatgtatga cgggggcggt gagtaccatt gtgtgtgctt    480
 accaggcttc catgggcgtg actgcgagcg caaggctgga ccctgtgaac aggcaggctc    540
 cccatgccgc aatggcgggc agtgccagga cgaccagggc tttgctctca acttcacgtg    600
 ccgctgcttg gtgggctttg tgggtgcccg ctgtgacgtg taaggtg                  647



      <210> 2004
      <211> 1456
      <212> DNA
      <213> Homo sapiens


      <400> 2004
 cccggtgcga cgatttcgtg gcgaaggtgc gggaacgtcc actcccgcgc gcccctctcg     60
 gggaccaggg cggcctccca ggaggagctt ggtttctggt cctcataccg tgtggttgag    120
 tgaaatcaaa acttccacga tagcaatgct gattggacaa agaatgtgtt gtggacacaa    180
 aaccaaactc tggaggacag aggattcatt ccaaggtaga gatggattcc tggaaatacc    240
 tcctcaaggc cagggtagag ccctcaatca cccactgccc ccagcttctc cttctcccat    300
 ctcctgcacc aagcaggtct ccaggtgttc cagctgctga tgacgtaaag tgtggagttg    360
 gtccaggaag gtcatgttcc atgcagcacg aggagcgctt tgtgtgagaa gttgaagacc    420
 tgctgtaaca catcatagag gaaagacata gcctggggcc ttctgcaact ggctgacttc    480
 caccttctcc tgggggaatc tgaagtcact tctgtccttt agacacaaga agggagagat    540
 tctcctcatt tggcccaaaa gcaccaaggt gttcctgcct agcaggccaa tggttctgag    600
 gcaggttata tcctagagat ccagaagagc cacagctgca cacctctagg gctgccagta    660
 gagggaagag gaggcccatt gagaaatcag gatgcttttg gcctggatga gctgaggtct    720
 tcataaaacc ttggatccta ggttctatga agacattcta tctatgcatg gctttaatgg    780
 agcacaaata gttttcattt ttctgagcat ttctctaaat ttttaattcc atttattgtt    840
 ttcatttaca tggcttctat atcagcatcc acaacctttt ggccaccagt ttggtggaag    900
 ataatttttc cacgaaaaat ggggtcaggg agggaatgct ttcagaggca ttagattctc    960
 attaggagac cacaacctag atccttcgca tctgcacttc acaatagggt tcctgctctt   1020
 ttgagaatcc aatgccactg ctgatctgac aggaggcaga gctcaggcgt taatgcttgt   1080
 tggttggcct gcttgcctcc tgctgtgcgg ccctgttcct accaggccag gaccagtacc   1140
 ccggtccatg gatgggggtg tgaaaaacct tgttctatat gacataaaag gaggtcgtcg   1200
 ctccacactc ttgatttttg caatggattg ttccaatatt cccagtaaac ttaagatata   1260
 tcaatccaaa tgaatattga tcaatcagat gagaaacgtc tgtgtgcata ctgttagaag   1320
 tatatacttt tagcccagat cctagcctcc agttttaccc tccattttgc ataggaaatc   1380
 aggatccctg ggccctatgg gtttctgtat tcagttagca aattacctat ctctggaaat   1440
 tcaacttttt aggact                                                   1456



      <210> 2005
      <211> 827
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> misc_feature
      <222> (1)...(827)
      <223> n = a,t,c or g


      <400> 2005
 tccgggtcgt cccacgcgtc cgacggatca gggttccagg aactcaggat ctgcagtgag     60
 gaccagacac cactgattgc aggaatgtgt tccctcccca tggcaagata ctacataatt    120
 aaatatgcag accagaaggc tctatacaca agagacggcc agctgctggt gggagatcct    180
 gttgcagaca actgctgtgc agagaagatc tgcacacttc ctaacagagg cttggaccgc    240
 accaaggtcc ccattttcct ggggatccag ggagggagcc gctgcctggc atgtgtggag    300
 acagaagagg ggccttccct acagctggag gatgtgaaca ttgaggaact gtacaaaggt    360
 ggtgaagagg ccacacgctt caccttcttc cagagcagct caggctccgc cttcaggctt    420
 gaggctgctg cctggcctgg ctggttcctg tgtggcccgg cagagcccca gcagccagta    480
 cagctcacca aggagagtga gccctcagcc cgtaccaagt tttactttga acagagctgg    540
 tagggagaca ggaaactgcg ttttagcctt gtgcccccaa accaagctca tcctgctcag    600
 ggtctannnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn    660
 nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn    720
 nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnaaggagg    780
 caggaaggga gagtcagaga gagaatggaa gataccatgc ttctaat                  827



      <210> 2006
      <211> 675
      <212> DNA
      <213> Homo sapiens


      <400> 2006
 atggcttttc cagctccagc cattatgttc atagtccagt cagcaggaag gaaaaaggtg     60
 agagagaagt ggtcccaggc tgcacccatg gcagaaggag gagggcagaa tcatcacgaa    120
 gtggtgaagt tcatggatgt ctatcagcgc agctactgcc atccaatcga gaccctggtg    180
 gacatcttcc aggagtaccc tgatgagatc gagtacatct tcaagccatc ctgtgtgccc    240
 ctgatgcgat gcgggggctg ctgcaatgac gagggcctgg agtgtgtgcc cactgaggag    300
 tccaacatca ccatgcagat tatgcggatc aaacctcacc aaggccagca cataggagag    360
 atgagcttcc tacagcacaa caaatgtgaa tgcagaccaa agaaagatag agcaagacaa    420
 gaaaaaaaat cagttcgagg aaagggaaag gggcaaaaac gaaagcgcaa gaaatcccgg    480
 tataagtcct ggagcgtgta cgttgatgtg acaagccgag gcggtgagcc gggcaggagg    540
 aaggagcctc cctcagggtt tcgggaacca gatctctcac caggaaagac tgatacagaa    600
 cgatcgatac agaaaccacg ctgccgccac cacaccatca ccatcgacag aacagtcctt    660
 aatccagaaa cctga                                                     675



      <210> 2007
      <211> 1031
      <212> DNA
      <213> Homo sapiens


      <400> 2007
 ctactactgg cctgccgcag catggactgt tacctggcca ttgtccatgc cacacgcaca     60
 ctgacccagc agcgccactt ggtcaagttc atatgtctgg gtttgaggaa cctgttcctg    120
 ttactgtccc tacgcatctt gcttttccga aggaccttct acccatccaa tgttagccca    180
 gtctgctatg aggacatggg caacaataca gcaaactggt ggatgctgtt acggatcctg    240
 ccccagtcct ttggcttcat cgtgccgctg cgatcatgct gttctgctac agattcaccc    300
 tgcatacgct gtttaaggcc catatggggc agaagcactg gaccatgtgg gtcatctttg    360
 ctgatgccct cattttcctg ctctgctggc tggcctacaa cctggacctg ctggcagaca    420
 ccctcatggg aacccagatg accaatgaga cctgtgagcg ccgcaacgac atcaaccagg    480
 ccctggatgc cactgagatt ctgggcatcc ttcacagcta cctcaatccc ctcatctacg    540
 ccttcattgg ccagaagttt tgccatggac ttctcaagat tatagccata catggcttga    600
 tcagcaagga ctccctgccc aaagacagca ggccttcctt tgttggctct tcttcagggc    660
 acacttccac tactctctaa gacctcttgc ctaagtgcag acccgtgggg ttcctccctt    720
 ctcttcacag tcacattcca agcctcatgt ccactagctc ttcttggtct cagtgtcagt    780
 gcagccccca ctgtggtcgc aggaagcaga ggaggccacg ttcttactag tttcccttgc    840
 atgatttaga aagcctgccc tggtacctca ccccttgcca taattactac atcacttgct    900
 ggagctctgt ccctcctgcc cttgagctca tggcactcta tgttctaaga agtgaaaatc    960
 tacactccag tgagacagct ctgcatactc attaggatgg ttaatgtcag aagaaagaaa   1020
 atcataaaat a                                                        1031



      <210> 2008
      <211> 437
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> misc_feature
      <222> (1)...(437)
      <223> n = a,t,c or g


      <400> 2008
 actatctgga atttggtcgt ccctggcagg aatttggcac gagccacttt cttgggacag     60
 tgaatcaaca atgccgtctt ctgtctcgtg gggcatcctc ctgctggcag gcctgtgctg    120
 cctggtccct gtctccctgg ctgaggatcc ccagggagat gctgcccata agacagatac    180
 atcccactgt gcccctgctc tggctaagtt tttatatttt tggactttta atacaatagg    240
 gtttcaccct gttcattgtc gtccttgttt tctgagacag agtttttctc tgtcgcccag    300
 gctgggagtg cagtaacgtg atctagaccc acttgcaacc tccgtctttc ttgggttcaa    360
 ggcgatttct cctgcctcaa gcctcttgag taagctnggg gactacaaag caactnccaa    420
 caaaacggnt aaatttt                                                   437



      <210> 2009
      <211> 901
      <212> DNA
      <213> Homo sapiens


      <400> 2009
 gtcgacgctt ctgcctcaaa gtgctaggat tacaggcatg agccactgcg tgcagctgat     60
 actatctctt aataacagac ttttgacaga atggtttcct atttgtgctt ttgtttttac    120
 tcagaagtca gacttctgct ggccattttt atggagggcc attgttgatt tcttgagttt    180
 cttttttctt ttaagtaaac tttatattga aatatgacct atgttcagag aagtgtacga    240
 gccataaatg ttcgtcttga atttctgcaa aatcaaaaca cccatataac accttcccag    300
 atcaagaatt agaaacttcc cttgggttcc ccactctcta aaagaaggag cccaccattt    360
 tggttaggca tcaatagctt attcagagta gaaaacccgg tattttgtag gaatggcctg    420
 tacgatattg gtaaaatgca acacattgca gggaaatatt tgaaaatctg gcccgtggca    480
 gtataactga gaatgtaaat tagtggctga aagtgtaact tagcagtcaa gatttcaggc    540
 catgccgggc gtggtggtgc atgccggtaa tctttgctac tggggaggct gaggcgggag    600
 aatcacttga acctgggagg tggaggtttc agtgacctga gatcgcacca ctgcactcca    660
 tcctgggcaa cagagcaaga ttccgtctta aaaaacacca ccaccaccac aaaagagatt    720
 tcaggccagt cagcatgtag aagagctgag caggttctca gtaaagccct tgtgaagagc    780
 ccctgaggaa agataatgca gagcattgat atgactagtg cacatcccct gcaaccagct    840
 gtcttgcttg ttgaaacttc ctactgctgc tttatcctcc tgtctttcct ttaaaaaaaa    900
 a                                                                    901



      <210> 2010
      <211> 184
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> misc_feature
      <222> (1)...(184)
      <223> n = a,t,c or g


      <400> 2010
 ttgggatgag gaaaggaaat tgagcagaag gtacaggagt aatagcaatt ccctgtagct     60
 ctcaaagcaa attttgagct catttttctt tttctgcaag ctnagnagca gaatgcccag    120
 agtcttccct ggtagatgca ggttccatag cgacgttctc ctgcaatgca cgtcgacgcg    180
 gccg                                                                 184



      <210> 2011
      <211> 1513
      <212> DNA
      <213> Homo sapiens


      <400> 2011
 tttcgtcttc gctgtcacga tttcgtgcta ggcgtggacc caactggcga ggctgctggg     60
 gttgcagcgg gacagttggg gcggccccgc aggcccaggt ttttgaaaat aaagttaatt    120
 cagagaaggt aaaactttct cttcggaatt tcccacataa tgattatgag gatgtttttg    180
 aagagccttc agaaagtggc agtgatccca gcatgtggac agccagaggc cccttcagaa    240
 gagacaggtg gagcagtgag gatgaggagg ctgcagggcc atcacaggct ctctcccctc    300
 tactttctga tacgcgcaaa attgtttctg aaggagaact agatcagttg gctcagattc    360
 ggccattaat attcaatttt catgagcaga cagccatcaa ggattgtttg aaaatccttg    420
 aggaaaaaac agcagcgtat gatatcatgc aggaatttat ggctttagaa cttaagaatc    480
 tgcctggtga gttctactct gggaatcaac caagcaacag agaaaaaaac agataccgag    540
 atattcttcc atatgattca acacgcgttc ctcttggaaa aagcaaggac tacatcaatg    600
 ctagttatat tagaatagtc aattgtggag aagagtattt ttatatcgct actcaaggac    660
 cactgctgag caccatagat gacttttggc aaatggtgtt ggaaaataat tcaaatgtta    720
 ttgccatgat aaccagagag atggaaggtg gaattatcaa atgctaccat tactggccca    780
 tttctctgaa gaagccattg gaattgaaac acttccgtgt attcctggag aactaccaga    840
 tacttcaata tttcatcatt cgaatgtttc aagttgtgga gaagtccacg ggaactagtc    900
 actctgtaaa acagttgcag ttcaccaagt ggccagacca tggcactcct gcctcagcag    960
 atagcttcat aaaatatatt cgttatgcaa ggaagagcca ccttacagga cccatggttg   1020
 ttcactgcag tgccggcata ggccggacag gggtgttcct atgtgtggat gtcgtgttct   1080
 gtgccatcgt aaaggactgt tcattcaaca tcatggatat agtggcccaa atgagagaac   1140
 aacgttctgg catggttcaa acgaaggagc agtatcactt ttgttacgat attgtgcttg   1200
 aagttcttcg gaaacttctg actttggatt aagaaagact tctgttgcct ctcacttgaa   1260
 attaccaagt gggtttgcac ctcctcataa agaacatgtt tgcactgtgc tgaagggctt   1320
 tgctatgcat acaatctgct ttcttggttt atcagtttat tttctttcta aaagctccct   1380
 gaagggcaat atcatttggc ttggggtgat cagtgtttac ttattgatct tgctagacaa   1440
 tatcaaaata acttcccaca ttttccagtg aaacagatgt tacataaaac gattgcagct   1500
 tggctatttg gtg                                                      1513



      <210> 2012
      <211> 777
      <212> DNA
      <213> Homo sapiens


      <400> 2012
 tttttttttt ttctgaagaa gcatttatta gcatgcaggg cccatgctag aggctcctta     60
 tttccagggc aaggccagcg agacagagcc cattgctcag gacgcagccc agattgcaaa    120
 gagaggacag cccatggtag cggaagaaat tctggcggag agcactgtac ttggggtcct    180
 tctctcgcag ctggcggtag ggatcgggac cctggtggct gcctggtacc tccccaccca    240
 ggcctcgctc cttctccacg gtttgcaggg cccacatggc agctgtggtg cggggttcca    300
 gccagcgggc gttgacagtg gccagcgtaa ggctcaggaa cagcaggtaa agctggctgg    360
 cctcccagaa tgtgagctga gcccaagcat gctgtgaagc caagatgcag aggttgatga    420
 aggcacagcc catggagatg tggaagtaga aggggaagag tttgctctgc actagtccga    480
 aggtatgtcg gggaaggctt cggaaaagca ggaagcctga gacgaaggtc acccacattt    540
 gcatgcccca ggcacctgac aagaccagta gatggaccat cttaatcagg cctcctaggt    600
 tcccgccttc ctccatcttg cagtccgtta ggaaccggga cctcaatccg cagcacccgg    660
 attccgagaa cagaggcgtc ggggccaaat gggctgaatc tggtacctca ctcccacgcc    720
 cccgggtgga cagcgaccct cctcggccgc gtcccctcgt gggtttcccc tcgtgcc       777



      <210> 2013
      <211> 895
      <212> DNA
      <213> Homo sapiens


      <400> 2013
 ctgcctttgg ctgtaccact tcccttttct tctcgcctgc acctccctca tctttcctct     60
 atgatgacat cgccctgggg aagagaagct gagaggaact cctcactcag ctagcttcag    120
 gagcatgacg tcatctctac catggaaatt ccactcactc tcctgtgccc ccacatttgt    180
 cctaggcctc agagtcccta taaagagaga ttcccaagtc agtatcagca caggacacag    240
 ctgggttctg aagcttctga gttctgcagc ctcacctctg agaaaacctc ttttccacca    300
 ataccatgaa gctctgcgtg actgtcctgt ctctcctcat gctagtagct gccttctgct    360
 ctccagcgct ctcagcacca atgggctcag accctcccac cgcctgctgc ttttcttaca    420
 ccgcgaggaa gcttcctcgc aactttgtgg tagattacta tgagaccagc agcctctgct    480
 cccagccagc tgtggtattc caaaccaaaa gaagcaagca agtctgtgct gatcccagtg    540
 agacctgggt ccaggagtac gtgtatgacc tggaactgaa ctgagctgct cagagacagg    600
 aagtcttcag ggaaggtcac ctgagcccgg atgcttctcc atgagacaca tctcctccat    660
 actcaggact cctctccgca gttcctgtcc cttctcttaa tttaatcttt tttatgtgcc    720
 gtgttattgt attaggtgtc atttccatta tttatattag tttagccaaa ggataagtgt    780
 cccctatggg gatggtccac tgtcactgtt tctctgctgt tgcaaataca tggataacac    840
 atttgattct gtgtgttttc ataataaaac tttaaaataa aatgcaaaaa aaaaa         895



      <210> 2014
      <211> 895
      <212> DNA
      <213> Homo sapiens


      <400> 2014
 ctgcctttgg ctgtaccact tcccttttct tctcgcctgc acctccctca tctttcctct     60
 atgatgacat cgccctgggg aagagaagct gagaggaact cctcactcag ctagcttcag    120
 gagcatgacg tcatctctac catggaaatt ccactcactc tcctgtgccc ccacatttgt    180
 cctaggcctc agagtcccta taaagagaga ttcccaagtc agtatcagca caggacacag    240
 ctgggttctg aagcttctga gttctgcagc ctcacctctg agaaaacctc ttttccacca    300
 ataccatgaa gctctgcgtg actgtcctgt ctctcctcat gctagtagct gccttctgct    360
 ctccagcgct ctcagcacca atgggctcag accctcccac cgcctgctgc ttttcttaca    420
 ccgcgaggaa gcttcctcgc aactttgtgg tagattacta tgagaccagc agcctctgct    480
 cccagccagc tgtggtattc caaaccaaaa gaagcaagca agtctgtgct gatcccagtg    540
 agacctgggt ccaggagtac gtgtatgacc tggaactgaa ctgagctgct cagagacagg    600
 aagtcttcag ggaaggtcac ctgagcccgg atgcttctcc atgagacaca tctcctccat    660
 actcaggact cctctccgca gttcctgtcc cttctcttaa tttaatcttt tttatgtgcc    720
 gtgttattgt attaggtgtc atttccatta tttatattag tttagccaaa ggataagtgt    780
 cccctatggg gatggtccac tgtcactgtt tctctgctgt tgcaaataca tggataacac    840
 atttgattct gtgtgttttc ataataaaac tttaaaataa aatgcaaaaa aaaaa         895



      <210> 2015
      <211> 490
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> misc_feature
      <222> (1)...(490)
      <223> n = a,t,c or g


      <400> 2015
 gctttttcca tagacgtaac attttgtctc ttatgtgcat tacatagttt cttccaagat     60
 gtcaacttat agttcattta tggtctctgc tttgtagaac ttcaaaattt ctctacaatc    120
 acagttatat attttttctg ggttcatatg ttgcttagaa cacttcccta tacgaaaaac    180
 atgaaaattt tttttcatat tttctttcat aagtgtctat ttacatatag gttatttatt    240
 actcttgcgt taattttgtg gtatagtgac atagaggagt ctacctttcc ccctctaatg    300
 aggtattgtc ccaacacagt gttgcataaa tcttttttcc aaatgtcagc ttttatcact    360
 tatcaattct cattgtactt gagtctgttt tagattgtct cttatattga tcttttagtt    420
 tataggaaag ctgctttact tnnncnnatt tctttttctt ctttgttttc gacggaccca    480
 attttaaaag                                                           490



      <210> 2016
      <211> 879
      <212> DNA
      <213> Homo sapiens


      <400> 2016
 ggcacgacca gcctctgtcg gaggcgaatt ctcagagtga gggttccctg tcacttgaga     60
 gaaggttccc tgtgacgtga ccttggggga cgtcattgcc ctttctgtcc ccacccaccc    120
 cctcggcagt tctgttggcc aggactttgg cctagacaaa ggatgggggt tgtggctgtg    180
 gagcggaagt gggtctcaac cactataaag cctctctgtg cccgtccgga gctggtgagg    240
 acagcctgcc agagtctggt ctctggacac tatgggcaca cgactcctcc cagctctgtt    300
 tcttgtcctc ctggtattgg gatttgaggt ccaggggacc caacagcccc agcaagatga    360
 gatgcctagc ccgaccttcc tcacccaggt gaaggaatct ctctccagtt actgggagtc    420
 agcaaagaca gccgcccaga acctgtacga gaagacatac ctgcccgctg tagatgagaa    480
 actcagggac ttgtacagca aaagcacagc agccatgagc acttacacag gcatttttac    540
 tgaccaagtt ctttctgtgc tgaagggaga ggagtaacag ccagaccccc catcagtgga    600
 caaggggaga gtcccctact cccctgatcc cccaggttca gactgagctc ccccttccca    660
 gtagctcttg catcctcctc ccaactctag cctgaattct tttcaataaa aaatacaatt    720
 caagttgctt ctcatggatg gcactgcttt tctgaggact caaggtgcca agatggaggg    780
 gctgactcag tccagccaac atttaatgag cacctacttt atgtatggag ctctaaccca    840
 tgggtccatg ggaataaagc agtgaatagt aacaataaa                           879



      <210> 2017
      <211> 542
      <212> DNA
      <213> Homo sapiens


      <400> 2017
 ccgggtcgac ccacgcgtcc gcggacgcgt gggcggacgc gtgggcggag gtggcagcca     60
 tctccttctc ggcatcatgg ccgccctcag accccttgtg aagcccaaga tcgtcaaaaa    120
 gagaaccaag aagttcatcc ggcaccagtc agaccgatat gtcaaaatta agcgtaactg    180
 gcggaaaccc agaggcattg acaacagggt tcgtagaaga ttcaagggcc agatcttgat    240
 gcccaacatt ggttatggaa gcaacaaaaa aacaaagcac atgctgccca gtggcttccg    300
 gaagttcctg gtccacaacg tcaaggagct ggaagtgctg ctgatgtgca acaaatctta    360
 ctgtgccgag atcgctcaca atgtttcctc caagaaccgc aaagccatcg tggaaagagc    420
 tgcccaactg gccatcagag tcaccaaccc caatgccagg ctgcgcagtg aagaaaatga    480
 gtaggcagct catgtgcacg ttttctgttt aaataaatgt aaaaactgcc ccaaaaaaaa    540
 aa                                                                   542



      <210> 2018
      <211> 552
      <212> DNA
      <213> Homo sapiens


      <400> 2018
 atgaacttga aactcacagg attgaaagag tctgctgggt accatgcagc ccctgaagga     60
 aacctgctga ccaccagcac ctgggagctc tgcagacacc cccaccccgc gatctttcag    120
 tgtaattggc ctgaagtgaa aaccacagcc tctgatggtg aacagaccac acgtgagcct    180
 gtgctcaaag ccatgttttt ggctgacacc catttgcttg gggaattcct aggccactgg    240
 ctggacaaat tacgaagagc taaaaatatt gtgaatggaa ccatattact ggtgttaagg    300
 agaagtaacc tgcctaagga ggagcacttg agaagaaatg acatcaaaga tgtacaaagt    360
 tatcatcaga aaaacaatga aggccagctt gaattcggag tgatttacca ctgcacagag    420
 gagcggctgt acacgggccg gcggggtcgg ggcgccttct gcaatggcca gcggctccgg    480
 gtctccgggg agacagatgg ccttcgaggc agcgagagga gctatggcca tggcccatct    540
 ctgctgctgt ga                                                        552



      <210> 2019
      <211> 3482
      <212> DNA
      <213> Homo sapiens


      <400> 2019
 atggtggaaa aggaaaagga tgccttagaa ggagagaaaa acatagctat cgaatttctt     60
 accttggaaa atgaaatatt tagaaaaaag aatcatgttt gtcaatatta tatttatgag    120
 ttgcagaaac gaattgctga aatggaaact caaaaggaaa atattcatga agataccaaa    180
 gaaattaatg agaagagcac tatacttatc aaatgaaatg aaagctaaga ataaagatgt    240
 aaaagataca gaaaagaaac tgaataaaat tacaaaattt attgaggaga ataaagaaaa    300
 atttacacag ctagatttgg aagatgttca agtttagaga aaagttaaaa catgccacga    360
 gtaaagccaa aaaactggag aaacaacttc aaaaagataa agaaaaggtt gaagaattta    420
 aaagtatgac ctgccaagag taacaatatc attaatgaaa caacaaccag aaacaatgcc    480
 ctcgagaagg aaaaagagaa agaagaacaa aaattaaagg aagttatgga tagccttaaa    540
 caggaaacac aagggcttca gaaagaaaaa gaaagtcgag agaaagaact tatgggtttc    600
 agcaaatcgg taaatgaagc acgttcaaag atggatgtag cccagtcaga acttgatatc    660
 tatctcagtc gtcataatac tgcagtgtct caattaacta aggctaagga agctctaatt    720
 gcagcttctg agactctcaa agaaaggaaa gctgcaatca gagatataga aggaaaactc    780
 cctcaaactg aacaagaatt aaaggagaaa gaaaaagaac ttcaaaaact tacacaagaa    840
 gaaacaaact ttaaaagttt ggttcatgat ctcttttcaa aaagttgaag aagcaaagag    900
 ctcattagca atgaatcgaa gtagggggaa agtccttgat gcaataattc aagaaaaaaa    960
 atctggcagg attccaggaa tatatggaag attgggggac ttaggagcca ttgatgaaaa   1020
 atacgacgtg gctatatcat cctgttgtca tgcactggac tacattgttg gttgatctat   1080
 ttgatatagc ccaagaaatg tgtaaacttc cttaaaagac aaaaatattg gagttgcaac   1140
 ttttataggt ttagataaga tggctgtatg ggcgaaaaag atgaccgaaa ttcaaactcc   1200
 tgaaaatact cctcgtttat ttgatttagt aaaagtaaaa gatgagaaaa ttcgccaagc   1260
 tttttatttt gctttacgag ataccttagt agctgacaac ttggatcaag ccacaagagt   1320
 agcatatcaa aaagatagaa gatggagagt ggtaacttta cagggacaaa tcatagaaca   1380
 gtcaggtaca atgactggtg gtggaagcaa agtaatgaaa ggaagaatgg gttcctcact   1440
 tgttattgaa atctctgaag aagaggtaaa caaaatggaa tcacagttgc aaaacgactc   1500
 taaaaaagca atgcaaatcc aagaacagaa agtacaactt gaagaaagag tagttaagtt   1560
 acggcatagt gaacgagaaa tgaggaacac actagaaaaa tttactgcaa gcatccagcg   1620
 tttaatagag caagaagaat atttgaatgt ccaagttaag gaacttgaag ctaatgtact   1680
 tgctacagcc cctgacaaaa aaaagcagaa attgctagaa gaaaacgtta gtgctttcaa   1740
 aacagaatat gatgctgtgg ctgagaaagc tggtaaagta gaagctgagg ttaaacgctt   1800
 acacaatacc atcgtagaaa tcaataatca taaactcaag gcccaacaag acaaactttg   1860
 ataaaataaa taaagcaatt tagatgaatg tgcttctgct attactaaag cccaagtagc   1920
 aatcaagact gcttgacaga aaccttcaaa agggcacaag aactctgtct tgccgtacag   1980
 agaaagaaat aaaagatact ggagaaagag gtggatgacc taacagcaga gctgaaaagt   2040
 ctttgaggac caaagcagca gaggtcgtaa agaatacaaa tgctgcagag gaatccttac   2100
 cagagatcca gaaagaacat cgcaatctgc ttcaagaatt aaaagttatt caagaaaatg   2160
 aacatgctct tcaaaaagat gcacttagta ttaagttgaa acttgaacaa atagatggtc   2220
 acattgctga acataattct aaaataaaat attggcacaa agagatttca aaaatatcac   2280
 tgcatcctat agaagataat cctattgaag agatttcggt tctaagccca gaggatcttg   2340
 aagcgatcaa gaatccagat tctataacaa atcaaattgc acttttggaa gcccggtgtc   2400
 atgaaatgaa accaaacctc ggtgccatcg cagagtataa aaagaaggaa gaattgtatt   2460
 tgcaacgggt agcagaattg gacaaaatta cttatgaaag agacagtttt agacaggcat   2520
 atgaagatct tcggaaacaa aggcttaatg aatttatggg caggttttta tataataaca   2580
 aataaattaa aggaaaatta ccaaatgctt actttgggag ggggacgccg aactcgagct   2640
 tgtagacagc ttggatcctt tctctgaagg gatcatggtt cagtgttcga ccacctaaga   2700
 aaagttggaa aaagatcttc aacctttcgg gaggagagaa aacacttagt tcattggctt   2760
 tagtatttgc tcttcaccac tacaagccca ctccccttta cttcatggat gagattgatg   2820
 cagcccttga ttttaaaaat gtgtccattg ttgcatttta tatatatgaa gcagtgtggt   2880
 tcctctccaa catcactgca ggaaatcagc agcaggtaca ggcagtaatt gatgccaatc   2940
 ttgtaccaat gataatacac cttttggata agggggattt tggcactcaa aaagaagctg   3000
 cttgggccat aagtaactta acaattagtg gaaggaaaga tcaagtggct taccttatcc   3060
 aacaaaatgt tatcccacct ttttgcaact tgctgactgt aaaagatgca caagttgtgc   3120
 aagtagtact cgatggacta agtaatatat taaaaatggc tgaagatgag gcagaaacca   3180
 taggcaatct tatagaagaa tgtggagggc tggagaaaat tgaacaactt caaaatcatg   3240
 aaaatgaaga catctacaaa ttggcctatg agatcattga tcagttcttc tcttcagatg   3300
 atgtatttaa taattttgta gttttcttaa ttttatatat aaacatagat ctggataaag   3360
 taatatatat aggctcttca ctcatgaagc agactcctag tcctggagtg actgtgtacg   3420
 agagcgtggt tgtggtgctg tatgtgaacg catgcaagct tgattcacct tcagggggct   3480
 ga                                                                  3482



      <210> 2020
      <211> 385
      <212> DNA
      <213> Homo sapiens


      <400> 2020
 gttccccagt ggtaagccgc aatctagctg acgtggcccc aaccccacat tccttcctgc     60
 cctgcaatgt ctgaagaaac cctacagagc aaattggcgg ctgcaaagaa aaagctgcct    120
 tggggtgcgg tgcaggggtc cagagccatg tcggacctgt tactgttact actggacctg    180
 actctgttac tgctgctgat gctgctgggc tttgccgggt actcagggca gttggctggg    240
 gtggcagtga gtgccggctc accccccatc cctacaagtt ccatgtggag ccctatggtg    300
 agactgggtg gcttctcacc agagctgcag catctccccc aaactctgct ccatcgctgt    360
 ccactaggat aaccctgcat ggttc                                          385



      <210> 2021
      <211> 1485
      <212> DNA
      <213> Homo sapiens


      <400> 2021
 tttttttttt ttccgcaggt ctgaaatgga ctttaattgg cttttgtctc tagaattacc     60
 cacccgttcc tgcgctctac ggttctccat gccccctcca gtttgggggt ctaaaccgaa    120
 caggagaggt gcaggggacc aggaggtgtc ctggcacaaa ggttcggggg tctccctggc    180
 aaggggtccc agggcctgga gcccgaggcc cagccaaaag cacacagcat caaaacatgt    240
 ttttagtggg aagctccagg ccctgcccct ccccgggggc ctcgaggtcg gggagcaggt    300
 gggcgtctgt ctgcctccag gtcatggcag tgcaggcggt gagctggggg ccggcagggg    360
 cgcggacagt gcggcgtggt cgaacagagg gttgcgcacc tccatttccc cggtcggggc    420
 caggcccggg cactcgtaca ccgtgaagtc tccgtcctca ttctcctcat ccgaggaggc    480
 cgtgtccagc tccttgggtg gctctttatg ccgctccagg cacagcatct gttgccgttg    540
 gtgctggtag tggtacatct ccgcgctctg tgccagccgc tggtccccag gcgagatccg    600
 gggagctgca ggtgagccag gggccttcgc agtggcgtag tcggccttct gagtcaggcg    660
 gatctcacgc tgcagcctgc accagcagag ggaggctacg gagagggcgg ctgcaccggc    720
 cacacagaac gccaggatca gcacaagggc gaggccgtcg ccttgccctc cccggggctc    780
 caggggcgac atgtgcaccg ggtcggatga cacaggggag cccagggagg tgtggggcgt    840
 gggcgtgggg gttcctggag tggaggggag gcccagctcc agcccctgcc cccgtgccga    900
 gaagcccagg gtggcaggct ccgggagccg ctgtcggtcc ttgggtaggg gcggagttga    960
 gtgtccagac tccttccggg caagctcctg ggccaggaag tcaatctcat cttccagtct   1020
 gggctggggc cggcccccgc ctggaggccg gcgcatcctg ggcacacaga gcccttgctg   1080
 gtcctcctgg aagggctgaa ggcagggccc acaggcatgt gcaccaggag gacaccttgc   1140
 ccgcctcttc agggcacagt ccaggctccc gggacaggcg gctacatccg ggaaggaagc   1200
 agaaggcagg gccggctcac ggccccgcag ggctcggccc ctgcacacgg cagcgctgcc   1260
 ccagccaccc gcccccgtca ccccccgagc tggccgggcc tggttctggc cattgttctg   1320
 gacatgccct tcctccctga cgccagggct cagaacccgg aagcgaacag tcctaggact   1380
 tatcagaact accctgcccc acccctcccc agggtccact tccaggcctg atagagccct   1440
 cagctcagaa gctgcctcgt gccaagctag gcgaataggt aatag                   1485



      <210> 2022
      <211> 638
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> misc_feature
      <222> (1)...(638)
      <223> n = a,t,c or g


      <400> 2022
 gtgactggtg gctcctgcct gtacacactc tcttgactca gtgtgctctc tcccctgcct     60
 gggccacagc tgcagcatcc tcaagagtct ccccgtacca gccactccct gctgatttgt    120
 cctgcctcct gcagtcctaa aggcagatct gaccctacca ccaccctgtt tctagccctt    180
 gcctggctcc ctactgctca caggatgagg tccatgcctg ggaactgcct ccctctgtgg    240
 cctcatctcc tagcccgccc tccccgtgag ctgtggcctg atgtcatggg tctgcctatg    300
 gttgcaagtg tgctgtgctt ttctggcttc tgggcctttg ctcacgccat tctgcctgcc    360
 aggagtgctc tcctttcctc acctcccacc tctgtacccc tcacatccct gttgaggtag    420
 aagtccatcc tggaagcttt cctagagccc ccaagctggc cttgatggtt ctgctgccac    480
 ccaccctggg tctcctttac agcacccacc tgctgccccg tcactgtttg taggggaata    540
 aaaaccgnca caaccagagg ccaagcccca gggcatccca aagggccctc cccgggaaag    600
 gccggcccct aaaccttaag ggggcctgga ggcccaat                            638



      <210> 2023
      <211> 556
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> misc_feature
      <222> (1)...(556)
      <223> n = a,t,c or g


      <400> 2023
 gttcacgtct gcagcagtaa gatgggagct ttgtccacgg agcggctaca gtactacact     60
 caggaactgg gggtccggga gcgcagtggc cacagcgtgt ccctcatcga cctctggggc    120
 ctccttgttg agtatctcct gtaccaggag gagaaccctg ccaagctgtc tgaccaacag    180
 gaggcggtcc gccagggtca gaacccttac cccatttaca ccagtgtcaa cgtccgcacc    240
 aacttgagtg gggaagattt tgcagagtgg tgcgagttca cgccctatga ggttggcttc    300
 cccaagtacg gggcttatgt tcccaccgag ctcttcggct cagaactctt catgggacga    360
 ttgctgcagc tccagcctga accccggatc tgttacctgc aaggtatgtg gggcagcgcc    420
 tttgccacca gcctggatga gatcttccta aagaccgccg gctcgggcct cagcttcctg    480
 gagtggtaca gaggcagtgt gaatatcaca gacgactgcc agaagcctca gctgcacaac    540
 ncctcgacgc gggaat                                                    556



      <210> 2024
      <211> 357
      <212> DNA
      <213> Homo sapiens


      <400> 2024
 ggcacgaggt ggggcagagg ctgcagcagg aaccaggcat ggaggtagat gcgggggagg     60
 ctgcagcaag agccgggcgt ggaggtagat ggggcagagg ctgcagcagg aacaggcgtg    120
 gcagtagatg gggctgaggc tgcagcagga acaggcgtgg cagtagatgg ggcagaggct    180
 gcagcagaac tgtgcaggag ggaagtcact cactcttcac tctcacgggc ttcccctggc    240
 tgctcagtag ggtcctttgg aagctgctga aaactgcaaa tgcttagccc acccaggctc    300
 cgtgtgacac agccaggagt gagctccaca gctctgtgtg gtggacatcc agcctcc       357



      <210> 2025
      <211> 1464
      <212> DNA
      <213> Homo sapiens


      <400> 2025
 actagttcta gatcgcgagc ggccgctcgc gatctataat gcctcttctg aagcagccat     60
 cccggcctct tggtactgct gaccccagcc aggctacagg gatcgattgg agctgtcctt    120
 ggggctgtaa ttggccccag ctgagcaggg caaacactga ggtcaactac aagccacagg    180
 ccccttcccc agcctcagtt cacagctgcc ctgttgcagg gaggcggtgg cccttctgtt    240
 gctagaccga gcctgtggga tataccaagg cagaggagcc catagccatg aggagcctcg    300
 gggccctgct cttgctgctg agcgcctgcc tggcggtgag cgctggccct gtgccaacgc    360
 cgcccgacaa catccaagtg caggaaaact tcaatatctc tcggatctat gggaagtggt    420
 acaacctggc catcggttcc acctgcccct ggctgaagaa gatcatggac aggatgacag    480
 tgagcacgct ggtgctggga gagggcgcta cagaggcgga gatcagcatg accagcactc    540
 gttggcggaa aggtgtctgt gaggagacgt ctggagctta tgagaaaaca gatactgatg    600
 ggaagtttct ctatcacaaa tccaaatgga acataaccat ggagtcctat gtggtccaca    660
 ccaactatga tgagtatgcc attttcctga ccaagaaatt cagccgccat catggaccca    720
 ccattactgc caagctctac gggcgggcgc cgcagctgag ggaaactctc ctgcaggact    780
 tcagagtggt tgcccagggt gtgggcatcc ctgaggactc catcttcacc atggctgacc    840
 gaggtgaatg tgtccctggg gagcaggaac cagagcccat cttaatcccg agagtccgga    900
 gggctgtgct accccaagaa gaggaaggat cagggggtgg gcaactggta actgaagtca    960
 ccaagaaaga agattcctgc cagctgggct actcggccgg tccctgcatg ggaatgacca   1020
 gcaggtattt ctataatggt acatccatgg cctgtgagac tttccagtac ggcggctgca   1080
 tgggcaacgg taacaacttc gtcacagaaa aggagtgtct gcagacctgc cgaactgtgg   1140
 cggcctgcaa tctccccata gtccggggcc cctgccgagc cttcatccag ctctgggcat   1200
 ttgatgctgt caaggggaag tgcgtcctct tcccctacgg gggctgccag ggcaacggga   1260
 acaagttcta ctcagagaag gagtgcagag agtactgcgg tgtccctggt gatggtgatg   1320
 aggagctgct gcgcttctcc aactgacaac tggccggtct gcaagtcaga ggatggccag   1380
 tgtctgtccc ggggtcctgt ggcaggcagc gccaagcaac ctgggtccaa ataaaaacta   1440
 aattgtaaac tcctaaaaaa aaaa                                          1464



      <210> 2026
      <211> 1520
      <212> DNA
      <213> Homo sapiens


      <400> 2026
 atggaggagc ttttaggaac tgtatttgtg atctggtggc tttggcctgg cagctacggc     60
 accagtgcag ctgatactca aggttcagat cagaagagga ggcttctcac cctgcagcag    120
 ggacctgtga gcatggcatg ccctggcttc ctgtgggcac ttgtgatctc cacctgtctt    180
 gaatttagca tggctcagac agtcactcag tctcaaccag agatgtctgt gcaggaggca    240
 gagaccgtga ccctgagctg cacatatgac accagtgaga gtgattatta tttattctgg    300
 tacaagcagc ctcccagcag gcagatgatt ctcgttattc gccaagaagc ttataagcaa    360
 cagaatgcaa cagagaatcg tttctctgtg aacttccaga aagcagccaa atccttcagt    420
 ctcaagatct cagactcaca gctgggggat gccgcgatgt atttctgtgc ttataggagc    480
 ggaagagatg acaagatcat ctttggaaaa gggacacgac ttcatattct ccccaatatc    540
 cagaaccctg accctgccgt gtaccagctg agagactcta aatccagtga caagtctgtc    600
 tgcctattca ccgattttga ttctcaaaca aatgtgtcac aaagtaagga ttctgatgtg    660
 tatatcacag acaaaactgt gctagacatg aggtctatgg acttcaagag caacagtgct    720
 gtggcctgga gcaacaaatc tgactttgca tgtgcaaacg ccttcaacaa cagcattatt    780
 ccagaagaca ccttcttccc cagcccagaa agttcctgtg atgtcaagct ggtcgagaaa    840
 agctttgaaa cagatacgaa cctaaacttt caaaacctgt cagtgattgg gttccgaatc    900
 ctcctcctga aagtggccgg gtttaatctg ctcatgacgc tgcggctgtg gtccagctga    960
 gatctgcaag attgtaagac agcctgtgct ccctcgctcc ttcctctgca ttgcccctct   1020
 tctccctctc caaacagagg gaactctcct acccccaagg aggtgaaagc tgctaccacc   1080
 tctgtgcccc cccggcaatg ccaccaactg gatcctaccc gaatttatga ttaagattgc   1140
 tgaagagctg ccaaacactg ctgccacccc ctctgttccc ttattgctgc ttgtcactgc   1200
 ctgacattca cggcagaggc aaggctgctg cagcctcccc tggctgtgca cattccctcc   1260
 tgctccccag agactgcctc cgccatccca cagatgatgg atcttcagtg ggttctcttg   1320
 ggctctaggt cctggagaat gttgtgaggg gtttattttt ttttaatagt gttcataaag   1380
 aaatacatag tattcttctt ctcaagacgt ggggggaaat tatctcatta tcgaggccct   1440
 gctatgctgt gtgtctgggc gtgttgtatg tcctgctgcc gatgccttca ttaaaatgat   1500
 ttggaagagc aaaaaaaaaa                                               1520



      <210> 2027
      <211> 1520
      <212> DNA
      <213> Homo sapiens


      <400> 2027
 atggaggagc ttttaggaac tgtatttgtg atctggtggc tttggcctgg cagctacggc     60
 accagtgcag ctgatactca aggttcagat cagaagagga ggcttctcac cctgcagcag    120
 ggacctgtga gcatggcatg ccctggcttc ctgtgggcac ttgtgatctc cacctgtctt    180
 gaatttagca tggctcagac agtcactcag tctcaaccag agatgtctgt gcaggaggca    240
 gagaccgtga ccctgagctg cacatatgac accagtgaga gtgattatta tttattctgg    300
 tacaagcagc ctcccagcag gcagatgatt ctcgttattc gccaagaagc ttataagcaa    360
 cagaatgcaa cagagaatcg tttctctgtg aacttccaga aagcagccaa atccttcagt    420
 ctcaagatct cagactcaca gctgggggat gccgcgatgt atttctgtgc ttataggagc    480
 ggaagagatg acaagatcat ctttggaaaa gggacacgac ttcatattct ccccaatatc    540
 cagaaccctg accctgccgt gtaccagctg agagactcta aatccagtga caagtctgtc    600
 tgcctattca ccgattttga ttctcaaaca aatgtgtcac aaagtaagga ttctgatgtg    660
 tatatcacag acaaaactgt gctagacatg aggtctatgg acttcaagag caacagtgct    720
 gtggcctgga gcaacaaatc tgactttgca tgtgcaaacg ccttcaacaa cagcattatt    780
 ccagaagaca ccttcttccc cagcccagaa agttcctgtg atgtcaagct ggtcgagaaa    840
 agctttgaaa cagatacgaa cctaaacttt caaaacctgt cagtgattgg gttccgaatc    900
 ctcctcctga aagtggccgg gtttaatctg ctcatgacgc tgcggctgtg gtccagctga    960
 gatctgcaag attgtaagac agcctgtgct ccctcgctcc ttcctctgca ttgcccctct   1020
 tctccctctc caaacagagg gaactctcct acccccaagg aggtgaaagc tgctaccacc   1080
 tctgtgcccc cccggcaatg ccaccaactg gatcctaccc gaatttatga ttaagattgc   1140
 tgaagagctg ccaaacactg ctgccacccc ctctgttccc ttattgctgc ttgtcactgc   1200
 ctgacattca cggcagaggc aaggctgctg cagcctcccc tggctgtgca cattccctcc   1260
 tgctccccag agactgcctc cgccatccca cagatgatgg atcttcagtg ggttctcttg   1320
 ggctctaggt cctggagaat gttgtgaggg gtttattttt ttttaatagt gttcataaag   1380
 aaatacatag tattcttctt ctcaagacgt ggggggaaat tatctcatta tcgaggccct   1440
 gctatgctgt gtgtctgggc gtgttgtatg tcctgctgcc gatgccttca ttaaaatgat   1500
 ttggaagagc aaaaaaaaaa                                               1520



      <210> 2028
      <211> 461
      <212> DNA
      <213> Homo sapiens


      <400> 2028
 ttttttttca gttgtttgtt tcctttaatt aacatctaaa atagattata catcttctat     60
 aattataata tggaaatgta tatgagcaaa atatataaat tttttggtga ctgcttaggg    120
 aagaatgatg tcagtgaagt tcatccaagg tcttaagcag cagcatctat gcagccaggg    180
 cgtggtcagc gtttggggac agaggtaaat atcccgcaat ccatgcatct ctttgatttc    240
 ttcttttagt gcctgaaatg tcagtgactt ttatagctgt agctcgtgga aaacttttct    300
 ttgagaattt gggtcactct gagctccccc tcagtcttga gtggcaaaca tccgatggtg    360
 aagtggaagc ccgcggatcc cgcggaggag aggcgctgcc gcggccgggc tccatgcagc    420
 catgcccggc cgacgtgacc cgccgcccgc ccacgcgtcc g                        461



      <210> 2029
      <211> 2469
      <212> DNA
      <213> Homo sapiens


      <400> 2029
 ggcacgaggg gggcggtccc cagcacacta gaggaagtcg tgctaccccc gcggagttgt     60
 cgtgtgttct ggattcattc cggcaccacc atgtcgaagg tttcctttaa gatcacgctg    120
 acgtcggacc cacggctgcc gtacaaagta ctcagtgttc ctgaaagtac acctttcaca    180
 gcagtcttaa agtttgcagc agaagaattt aaagttcctg ctgcaacaag tgcaattatt    240
 accaatgatg gaataggaat aaatcctgca cagactgctg gaaatgtttt tctaaaacat    300
 ggttcagaac tgcggattat tcctagagat cgtgttggaa gttgttaata tctgctactt    360
 ggaacatacg attgcctttc agaataaata ttggtatttt ttgttgttgt aaaattgaaa    420
 tcaggcattt aacatactat gaaaacacca ggagtcaatg attaatgaaa ggtgactcat    480
 ctgtcccttt ttgttgtcca tactcttcct atgaagaggg aatgcgtatg aattaaggct    540
 actactgtca cagaagatca tagtctttga tgctacctca caacacaaac aggtagttcg    600
 ttgggggcaa atgaattagc caactgttaa ctggaagctt ttgataattt ttttttttag    660
 aacaatttgg aacattaaaa tttactgaat cgtatatatt catctgagat aaaaatataa    720
 aaagaattat ggaccctgga tggcaatttg cttgatagca tctgatttgc agactcataa    780
 tttgattttt aattaaatat ataggttatg atgaagtgaa tagacatatc agtgaacagt    840
 taactatatt aaatttttat catttacttt ttttaagatt cagacctcag ttatataaat    900
 ttcagtttaa tatcaaccaa aaaattaaaa ttttaatcta acccttatgt gtataaattg    960
 gtgtcccata ccagctttta atggtggacc tatagaatcc agtactttta atggtgggaa   1020
 tttacagtag aagcatcctt tgctgagtta tacattcctt tatcaatctc ttttgataca   1080
 acatttaaaa caagtagctt caagaaacca ctggtgtttt gaggatagta tttctaaata   1140
 gcattcagga acagagtatt attgcacaga tctgaagatc aaaaaaaagc tcaaggaaat   1200
 acagatcgga agtgctgatg agttatattt attgaaaacc caacttttaa ggaagtgcta   1260
 agatcagtca cccatgtgaa taagaagcca ggaaaggaaa gatggggaag cccagatcac   1320
 caggcttcta ttaaggagga aagcaacaga ggaaacagtg aaggggaaca gaagggggta   1380
 gcaaagtgtt acagaaaagc ggactggata gacaaaactg cagaaggtgt atgttgggga   1440
 gaactgaaag ggaaaacaaa atacttgaca tagtcttaag tagaagaagg cagttagaga   1500
 aaacaaagta tctactggcc ttgtcaacat acagacttca aaatacccct tatgagaatc   1560
 caaagaatga tgtgtgtaag ggaagatttt atttgccctt ccggaagaaa tcagtatcta   1620
 tgcaaatctt gaaagacaaa atcaaagccc attaatgatt cagaatcagt gcttgacctc   1680
 ctgtattctg aatggtgaac tctggaagca gggattgtgt ctggctcttt ttagagctgg   1740
 aagtgtagtg gctttcatta aatacttgct gtaaagtctt tctaagacca attattatct   1800
 tagcatgttt cagtatcttc tctatcatag gccctaagtt cattggggga aaaaaaataa   1860
 gaagattcaa cagaatcagc atttgaagtg taccattggt agttgtttat gaaattacca   1920
 gatattcata aatgtgacaa atgaacagca ggattatgaa ttatcaaagg aaaaagtatt   1980
 tgctgaggtg aaaaaatctg atgtttgagg aagtttttat ttttatttat ttgttttgtt   2040
 tttttttttt ttggagggca gacttttttg cccaaggctt ttcctgcctc agcctcacga   2100
 gtagctggga ctacaggcat ggccccacca cgcccagcta atttttgtat ttttagcaga   2160
 gacagggagg aagtttttat ttttataaac aaaatctgat gttcagaggc cccgtttctt   2220
 acaataaatg ttgagtctta gttaagcagg aatttatgaa cacccatttc ctgacttttt   2280
 gctttaattt agatttttct ccatcctgtt tctagcacaa aaatttgcct gctgtgttac   2340
 aaaaataaat ttatgttgtc ctgtgccata aagtgatata tttaatattt ttattctttg   2400
 gttttgaaca ttgtaagttc ctaaaaacat tttattaaac aagtagacat tttgttatta   2460
 aaaaaaaaa                                                           2469



      <210> 2030
      <211> 499
      <212> DNA
      <213> Homo sapiens


      <400> 2030
 cagcagctga tctgtcaacc ccggccagag ccgagccgcc tgaggcctgc agtgttctcc     60
 atcaccactg tgatggcatc cgcttccgtg actgtcactg tgcaccctcc gcctgtcctg    120
 ggcccacgca ggacccccaa gcggggctct gcacaggcca ggagggctac ccagggactg    180
 accacgggtt gttcatgggt cctcacctgc ttttccaggt ccagggtgag aggacgaatt    240
 tgaaggtaga agtcacagag ttgcaggatg tggagtgcga ggagtggccc cggggaagca    300
 gctccaactg agggtgatta aaatctgaag caggccgggc gcagtggctc acatctgtaa    360
 tcccagcact tttggaggcc gaggcaggtg gatcacctga cgtcaggagt tcgagaccag    420
 cctgggcaac atggtgaaac cccgtctctg ctaaaaatac aaagttagcc aggcatggtg    480
 gcgagcgcct gtaatccca                                                 499



      <210> 2031
      <211> 2329
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> misc_feature
      <222> (1)...(2329)
      <223> n = a,t,c or g


      <400> 2031
 tccccacctg aacctgtggt taccaatgct atgcgagaag acctggcgga tatctgttac     60
 atcagggctg tgaccgtcta cgacaagccc gcatctttct ttaaagagac acctctggac    120
 ctgcagcacc ggctcttcat gaagctgggc agcatgcact ctccgttcag ggcccgctca    180
 gaacctgagg acccagtcac ggagcggtcg gccttcacgg agcgggatgc tgggagcggg    240
 ctggtgacgc gtctccgtga gcggccagcc ctgctggtca gcagcacgag ctggacagag    300
 gacgaagact tctccatcct gctggcagct ttagaaagta gagtttgaac aactgactct    360
 tgatggacac aaccttcctt ctctcgtctg tgtgataaca ggcaaagggc ctctgaggga    420
 gtattatagc cgcctcatcc accagaagca cttccagcac atccaggtct gcaccccctg    480
 gctggaggcc gaggactacc ccctgcttct agggtcggcg gacctgggtg tctgtctgca    540
 cacgtcctcc agtggcctgg acctgcccat gaaggtggtg gacatgtttg ggtgctgttt    600
 gcctgtgtgt gctgtgaact tcaagtgttt acatgagctg gtgaaacatg aagaaaatgg    660
 cctggtcttt gaggactcag aggaactggc agctcagctg cagatgcttt tctcaaactt    720
 tcctgatcct gcgggcaagc taaaccagtt ccggaagaac ctgcgggagt cgcagcagct    780
 ccgatgggat gagagctggg tgcagactgt gctccctttg gttatggaca cataactcct    840
 gggccagagg ctaaaacccc aggacccctg ctgtccttcc cgcagcttct tcttggagtc    900
 tcagggcaaa ccctttcgag cagcacctcc cagtggccag aagctgaaat gacagcagtg    960
 gtactgcctg gtaaaagaat tggttctgtg acccgggaag ctttggttgg ccttgatttc   1020
 ttctctggag gcttggaaac gcttcctctc ttcttctgtt cttcacgccc catgcccctg   1080
 ctagcgtatt actgttctgt gacttccctg tgacctctgc agaactcctc atcctgcgtt   1140
 tggtctccag gtgtcccctt tctgccgtgt tcctaacatt ttgattcctg tcttgaaaaa   1200
 agcacctgct gcaccgtaag cccagggatg tggcagctgc agtgggcttg gctttgtgag   1260
 gaactgagtg tgtccacgtt gggggaacat catacttgat acacacgttt ttatttgcac   1320
 aaagaaaatg ctgtttttgg agccagaatt ttcatgtctg atttatggtg attttcttaa   1380
 gaaccagaac tgctggcaga aagggggcac ccacacgctt agatagccga tgtcttatta   1440
 gagggcagtt tgtggttcct gatttggaaa ttaacattct ccaaacattc cagtccaatg   1500
 aaagttttat ccgctttccc atataaaaat tcttcccatg agagtgactt gattctcaca   1560
 atcccgttgg agtcgtgtgt gagtcctaca gtattaggtt cagcattgcc atctccaagt   1620
 gctcttcgta gggaaacagt ttctggtcat gacaagcttc cacttcccat ctgatcccgg   1680
 cccggccggc ctctgcccga gttccctgca tggtgtggga gtgtggggca tgctagcttt   1740
 acgccggcgc ccagttcttt cacttccact ggagtcctgc agggacagct cggggaccat   1800
 gcaggcccgg gtgggcgtgg ggactcaact agctcagtgg tgaacagctg gcacgtctgt   1860
 gggttgtgga cggtaaaggc cacgtagacc tcaggagccc gctggtgctc ccggcaggca   1920
 gccagcctcc gcaggacccc gaccagcgac acgatggctt ctgggcaata cagcacgtca   1980
 gcaaatagct ccggtggccc tgggtggact ccttggccat cagggtctcc gccagcacct   2040
 cgtacagctc atccaaaggc tctgtgtgga cagcctcgtg ctttttgatg agttctgaga   2100
 gaaagcaccg ggcatacttg actgacggcg ggtgcttcac acacacagga tgcttcacag   2160
 tctacttctg caaaatatcc cgcagcagct cagaatctga tgagtctctt aactttgctt   2220
 ctaagctctg ccaggggaag gagcgcaggg cgcgcgccgc caggaagcgg cgcttgaaac   2280
 tctgcagcaa gagttcgctc cccgacgaaa tcgtcggtnn nngaaaaag               2329



      <210> 2032
      <211> 662
      <212> DNA
      <213> Homo sapiens


      <400> 2032
 taatcctcgc gacgggccca ccactgccgc ctgctgggcc gctgcgtggg cttcggcaac     60
 taccggccct tcctgtgcct gctgcttcat gccgccggcg tcctgctcca cgtctctgtg    120
 ctgctgggcc ctgcactgtc ggccctgctg cgagcccaca cgcccctcca catggctgcc    180
 ctcctcctgc ttccctggct catgttgctc acagccttaa agcccactct catcttgcaa    240
 gcctctgaag ccaccagttt tctgagatgt tcctcccggc cccggagacc acggatgtgg    300
 ctaccttctc agaatataga tgtttccatt gcggcaggcc gcggcaagcc ggaactcaac    360
 atcaaactgg ccagaaacct ctaggaagac ggggacgctg ggaaggctca tctgcaaaca    420
 agaagcgcaa acactccaat ttctctggag cccccgtccc tccctgccct gtcagtaact    480
 cctctgagtg agtgcctggt ctaaagtccc aatctcctca cttacaccca gtttaaactc    540
 atacagtttt tcaggaggga aacttggggc aacatttagc aaaagccttt tagtctgtgc    600
 cttttgacta aacgatgcca cttctaggac tgcgatccta aggatgtact taaacaaccg    660
 tg                                                                   662



      <210> 2033
      <211> 387
      <212> DNA
      <213> Homo sapiens


      <400> 2033
 atggcctgca gggtcctgca aggtctcccc tttgcctgcc tgtccagccc catctgttcc     60
 cactctgccc ttactcttga tcattctctc ctgtgcctga actttttctt caacccttat    120
 gcccttctgc ctaactttta cttatttggc aagttccagc tcagaattcc ttcctctgga    180
 aagccttttc tgacttccga agaccaggac cctgctggga tctttgagct tgtggaggtg    240
 gtcggcaatg gaacctacgg acaggtgtac aaggtgagac gaatggtgtg gaagtatgac    300
 ctccacatct gcagggcagt cttgggagga gtggaaggaa gtagattcct ggtctgcagg    360
 tctgaagggg gctatgggag atgctag                                        387



      <210> 2034
      <211> 637
      <212> DNA
      <213> Homo sapiens


      <400> 2034
 ataaacttgt tttaaattgg cttattgctg gtctctcaag gcttcctatt tttgtttgct     60
 ttagtctctc taaaatttca gggaaaaact atgagtctca aaatgcttat aagcaggaac    120
 aagctgattt tactactagg aatagtcttt tttgaacgag gtaaatctgc aactctttcg    180
 ctccccaaag ctcccagttg tgggcagagt ctggttaagg tacagccttg gaattatttt    240
 aacattttca gtcgcattct tggaggaagc caagtggaga agggttccta tccctggcag    300
 gtatctctga aacaaaggca gaagcatatt tgtggaggaa gcatcgtctc accacagtgg    360
 gtgatcacgg cggctcactg cattgcaaac agaaacattg tgtctacttt gaatgttact    420
 gctggagagt atgacttaag ccagacagac ccaggagagc aaactctcac tattgaaact    480
 gtcatcatac atccacattt ctccaccaag aaaccaatgg actatgatat tgcccttttg    540
 aagatggctg gagccttcca atttggccac tttgtggggc ccatatgtct tccagagctg    600
 cgggagcaat ttgaggctgg ttttatttgt acaactg                             637



      <210> 2035
      <211> 446
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> misc_feature
      <222> (1)...(446)
      <223> n = a,t,c or g


      <400> 2035
 gaggcgctnn nnnncccagg catcgcagca cgtctgngca attnnggnta angcaggata     60
 cagggctgca gttgttgggt gaagctttgc ccgaaagttg agaaatgggt gcagcgcacg    120
 gatgcagaac aggagtcgca gaccaaagca gagatccagg atatgaagca agagttatcc    180
 gcggtcaata tgatggacaa gtttgccaga tctgccaggc tggaaagaaa gatcaacaag    240
 atgatgaata agctcaaaac tcatgtgaaa gtacagacag ctcaatcagg aatgctaaaa    300
 tgggttataa gtgttgcttt ctacaaattg ccaggtaccg tgatcaggct ataaggcagt    360
 cttgtggggt tatccattac ttgacagggt ctcgctctgt tgcccaggct ggagtgcagt    420
 gggccatcta tgctcactgt agcctc                                         446



      <210> 2036
      <211> 1397
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> misc_feature
      <222> (1)...(1397)
      <223> n = a,t,c or g


      <400> 2036
 tttttttttt tgaacactcc cacgcgcact ttattaagta cggaaggaca ggtcacaaca     60
 ggggtggagg tggcggggaa ggcccagccc ccacccacca tcactggcac acaataaata    120
 aataagtaaa tagccaagtg ggcacgggag agaggtggta ctgaaaacac tgaccgcaca    180
 gggggacacg aaagcccccc ttcgagctgt ggccatcaac gctgtacggg taccatgacc    240
 aggaaagggt ggggcttggc cacagaagcc ccagagcatc acaagtcttt gtaaaggaga    300
 ggtgtcttta ggacgtggac cactcttatt tactgactga aacctggacc cctagctggt    360
 cccgtgagac cccagattta ttcaaggggg gccactgttt tctcagggtt ttgggattgt    420
 ttcttatttg agggatncta aaagacccan tgggtcacta tcacttgggg tcctgatggg    480
 gtccacccag ggacctagga catgcgaggg tcatcgtcac ttaggcttcc gattggtcca    540
 ctcgggctcc aggacgtgaa agggtcacta ttacttagga acctaaactg gtaccccaca    600
 ggacccaaca ttgatgagtc actatcactt agcctttgga ttggtccacc caggacaata    660
 agggttgtgg ttccctagac ctctggttga caaggaccca agggccagga cctgaggggc    720
 agagagagct ctagaagccc cagggaaggg ggagaagact aagtactcag ggatagaggg    780
 aatcttcagc aggcaccagg gcccagattt caaggagggg aggtgacagg gaagaaataa    840
 ggccacctgg ctgggtcagg ccaagatgaa tccatagggg accagcttct ggggcagcaa    900
 agagtgccca gccactgctg ggagggggtt gcaagggccc tcaaaccttc cccgggtccc    960
 agccccaccc cggtgcagaa ctggaccaag gagccggttg tgcttaacat ggctcgtgac   1020
 ccatcgcctc cacctacggg atcagggagt ggggaggggt gggcctgtgg ctgcaggtgc   1080
 agtgggctca gtcctccaac ccctctgtca agtctgcgat gctctccaca tagtaatggg   1140
 gcacgaggtc gtgctggccg gccgctaggt aggcctgggc ctcttctagg cgggagactc   1200
 ctgtgagcgt gagcacagtg gtcatgccgc agcggtggcc aaagaggatg tcggtctcca   1260
 ggcggtcacc caccataagc gtgcgtgcgg ggtcgatgct gaagttctcc gtgatgcact   1320
 cgaacatgta ggggctgggc ttgcccacca ccagggcctg gcgtcccgag gctggaattc   1380
 caccacactg gacgagg                                                  1397



      <210> 2037
      <211> 757
      <212> DNA
      <213> Homo sapiens


      <400> 2037
 ttttctgggc ttggtgcatt tattcaggtt tgagagctga ggagggcaga gctcgcacag     60
 ctgtgaggca gggctgggcc ggacaggagc tgcttcatcc ttcaacaaac cctggcctgg    120
 ggtgaccagc ctggtggggg agatggagtc gggatggagg acaaaggggg gagcagggga    180
 cagagcccag gaggaagcaa gggagggcac aaaggagggg caggtggctt caggtgagaa    240
 gcaggaggga gaaaggggac cagcagtggg tctaggggaa ggggctgggg tgagggaggc    300
 tgagaagggg cagaagatgt ggcccacagc ggctcccaac agccccaggt cctcaggaag    360
 cccctcacct gtccctgtcc ccatgggccc ccagactcac tgcagaccca ggaggcctgg    420
 catagcgagt gtgcaggtgt gtgcaggtgt gtgcagacca gcacgtgtgc ctgtgcacgg    480
 gtagacagca tgtgtgccag tgtgagtggc gtgtgtgtaa gtgggtgttc gcatgtggag    540
 gcatgtgcca gtctgtacac gtttgctcat gcgtgagtgt gtgtgcatgt ggttatgcac    600
 atgtaaagga ccagaggcgg gaatcagaag ggcacggtgg gcatccctcc aggaagagga    660
 gggactcagg ctgacctcgc cctcccacaa gaagagtcag gccttggggg ccgcggctgt    720
 ctgagtggtc aggctggggc tgccattaac ctctgtg                             757



      <210> 2038
      <211> 1873
      <212> DNA
      <213> Homo sapiens


      <400> 2038
 tcaggttcat attgctaaac tgcccagcag ggagggattt tttcaattag tgttctcact     60
 ggtgaggcaa acctgatgcc ttcccctctt cctcagaacc ggctttatca cattgaaaac    120
 ctttgctcct ccgacggatc gagtctgctt tccctctgga tgtgagcatt gctttgtctg    180
 ctggtgactg aacatctcta ccttgtgtca attggccatt tgtcgtgtgt gtgtgtgtgc    240
 gtgtgtgtgt gtgtgtgtgt gtgtatgatt ttctaattcc tagtcatttt tctattgatt    300
 gttttgcaaa agccatttac atcttaagga tattgataat cttttgttat atttgatgca    360
 aatatttttt tccagtttat aggttgcctt ttaattttgt gtttcaggta gataaaagtt    420
 aaacgatttt cttaggttag tttatcactg tggtttctga acttgttatg tgtagatctt    480
 ttccacccca agagtacata aatattaatc catactttct tatggaactt gtatggtttc    540
 gttttttaca tttaaacctt cttccccgtg gtgtgtgttg tggaatctgt gtttgtgtga    600
 ggaggggcat ggtgctctca gaacccacct cctgtggcca gagagccctg tcctgtgagg    660
 gtggttatca cagtggcagg gttcaattca gaagaccttg agggcaggct gatgtttcct    720
 gaatgggccc ctggttgttg cttgtccctg actctccatt tccccatttg agtggatttg    780
 gaccttaata gggcactgga gctggttcga atcctgactg gactacttgg caactttatg    840
 tctgggagca agttacttaa cctccccaag cctgtgtctg tgaaatgcgg gtaaatgaat    900
 gtagatgttt ggcagcagct actccttgtt gagctctcac agtgaactct cctgcctctg    960
 ccctccttcc ccgcctcccc tggtgcctag cgtcaggtct agccacttcc tcctgggccc   1020
 ctctcccttt tctgtggctg gctgcctgcc cgcctggcgc tggacctttc atgtaacggg   1080
 aatcagcatg tatattctgg tctggtctgt ttctacactt aattgttgtt tccagagagt   1140
 attctccctg taccggcaga gttcacaaac acatttgaag aggctttttc tcaggattct   1200
 taaccttccc aaaggaagtc ccatggatgg gtttctagaa gtctataaat gctctgaaat   1260
 tgtatttttc tgtggaaagc ataactttca tctgcttgtt cgtgctcaaa aaagatcatg   1320
 aatgaatgat tgcatgattt tatgccattg tgcttatact aaaggatatg tagcccatct   1380
 cttgagctgt taaactgttt tgactacttt aaatcgtgca gctgtgagca tctctgtaaa   1440
 tttagtgtac acatgtatcc cctggagtgg cattgcctcg gcagtgagca cttatggttt   1500
 tataactctc ttcacagact caaatgactc ccagaaagct acacttcctg ttgtgagtat   1560
 atgatatcca tttccctaca tagccactaa catcaggttt ttacaatttt atttatttct   1620
 tgctacttta agaaattttt gtggtgaaat acatataata gaagttgact atctgaatca   1680
 tttttaagta tacattcagt agtgttaagt atgtcgccat tgttgtacaa ccaatctcca   1740
 gaactttttc atcttgcaaa acaaactctg tacccattaa ataacattaa acattccatt   1800
 ccctccagcc tcagcaaccc cattctactt tctgtttctg tgagtttgac tattccaagc   1860
 acttcatatc agt                                                      1873



      <210> 2039
      <211> 1125
      <212> DNA
      <213> Homo sapiens


      <400> 2039
 ttaagccagc agggaagggc agatgtgggc tgctgtttca tgcatgcaca gaggcaggcc     60
 ctggctcttg cagcagcgga cttcacgaat gtggaatgtg gaggttacac agcgatgcct    120
 agactgtctg tccttagacc gaagggcagc agaaaggctc agggggcttg ctctatattc    180
 cttagacatc tccggagatt ttctcagcat cagaatcaga tcctcccatg gcctgcggct    240
 acttttaaga aagtttggca accttttgga tatgtcctct tctctttttt gactttccag    300
 gctgtaaacc ttcagaagct tccacatgtg gtgccagtgg gctccttgaa aaatgacttc    360
 cctgggaacc agaacatcca ggttggcctc aaacttgctg ccaaacagga actgtggcaa    420
 gccggagagg attctgatgc ttggaagtgg gcgaatgttt tgattttcaa gcaaagaaaa    480
 agctagcttc ctggtgaacc ctgtgggcat gaaccggtac agcgtggaca cctccgcctc    540
 cacctttaac cacaggggct ccttgcaccc ctcctcctcg ctgtactgca agaggcagaa    600
 ctctggagac agccaccttg ggggtggtcc tgctgccacc gctggtggtc cccgcactag    660
 ccccatgtct tctggtggcc cctcggcacc tgggatgagg cctccagcct ccagccccaa    720
 gagaaacacg acctctctat taaactctgg cttggaacct acattttctt ttcgtatcac    780
 ctttggattc atgtgacctt gtccgcagtg tgctgacttg cctctctcca cctgggaatt    840
 ccccaagttt cgatatgcac aggtatcagc tgccttgtgt acattaatac aggaagtgtt    900
 aggaggcgtt tgctcttctg gttctatttc attaagcaag ctgaagctgg atgtagaacc    960
 gtagaatcct agagttgggg aaaagaggtc ttgggggaca tctggacggc tcccctccag   1020
 agtagaacct tctcccccgt gggttccaca ttgctcagcg atgatgagag ctcctgttgg   1080
 tccacattct ggccagcatt tgtcagtatt acagatttcg cccat                   1125



      <210> 2040
      <211> 439
      <212> DNA
      <213> Homo sapiens


      <400> 2040
 gcccgagcct ctggccggcc tggaccaact gcgggagctc agcctggcgc acaaccggct     60
 ccgggtcggc gacatcgggc caggcacctg gcatgagctc caagccctcc agatgctgga    120
 cctcagccac aatgagctgt cctttgtgcc cccggacctg cctgaggccc tagaggagct    180
 gcacctcgag ggcaaccgca tcggccacgt gggccccgag gccttcctca gcacaccccg    240
 cctgcgtgcc ctcttcctca ggtgccccga gggtgaccgg aggggtggag gtgggcaggg    300
 gagggcctgg gagggtcatg accgcctctc tgtgcagggc caacaggctt cacatgacga    360
 gcatcgcggc tgaggccttc ctggggctcc caaacctgcg tgtggtggac acggcaggga    420
 atccggagca ggtcctgat                                                 439



      <210> 2041
      <211> 498
      <212> DNA
      <213> Homo sapiens


      <400> 2041
 agtacaagga agtggtgaca cagcatttcc tatgagtgac ctatgagacc caccccatat     60
 attatctgaa gatcagccaa ccatctggta atcccaagaa aatcatttgg atggactgtg    120
 gaattcacgc cagagaatgg attgctcctg ctttttgcca atggttcgtc aaagaaattc    180
 tacaaaacca taaagacaac tcaaggatac gcaagctcct tatgaacctg gacttctatg    240
 tccttccagt tcttaacata gatggttata tctacacttg gacaactgat cgtctttgga    300
 ggaaatcccg ttcaccccat aataatggca catgttttgg gacggatctc aatcgaaatt    360
 tcaatgcttc ttggtgtagt attggtgcct ctagaaactg ccaagatcaa acattctgtg    420
 ggacagggcc agtgtctgaa ccagagacta aagctgttgc cagcttcata gagagcaaga    480
 atgatgattt ttgtgctt                                                  498



      <210> 2042
      <211> 857
      <212> DNA
      <213> Homo sapiens


      <400> 2042
 acaagcgccg cccacgcgtc cggagttatc tgttttcaaa aaattctcag atttccttat     60
 ccaaagtgca gttttaagtg acagtggtaa ctatttctgt agtaccaaag gacaactctt    120
 tctctgggat aaaacttcaa atatagtaaa gataaaagtc caaggacctg atggctatag    180
 aagagacctc atgacagctg gagttctctg gggactgttt ggtgtccttg gtttcactgg    240
 tgttgctttg ctgttgtatg ccttgttcca caagatatca ggagaaagtt ctgccactaa    300
 tgaacccaga ggggcttcca ggccaaatcc tcaagagttc acctattcaa gcccaacccc    360
 agacatggag gagctgcagc cagtgtatgt caatgtgggc tctgtagatg tggatgtggt    420
 ttattctcag gtctggagca tgcagcagcc agaaagctca gcaaacatca ggacacttct    480
 ggagaacaag gactcccaag tcatctactc ttctgtgaag aaatcataac acttggagga    540
 atcagaaggg aagatcaaca gcaaggatgg ggcatcatta agacttgcta taaaacctta    600
 tgaaaatgct tgaggcttat cacctgccac agccagaacg tgcctcagga ggcacctcct    660
 gtcatttttg tcctgatgat gtttcttctc caatatcttc ttttacctat caatattcat    720
 tgaactgctg ctacatccag acactgtgca aataaattat ttctgctacc ttctcttaag    780
 caatcagtgt gtaaagattt gagggaagaa tgaataagag ataccagggc tcaccttcat    840
 ctactgcgaa gggaggt                                                   857



      <210> 2043
      <211> 1773
      <212> DNA
      <213> Homo sapiens


      <400> 2043
 tttttttttt ttcaaaatat gaaaatttat tttgcatagg aaacaataat ctctggtaaa     60
 catcattact gcatctaaca aaacaatgcc ttcaattaaa gggggaaagt gagtttttaa    120
 acattagggt taatttagaa gaaaatacag tatataataa tctcaacatc atgtttaggg    180
 taaaaatgct ataatgtgaa aaaagtccct aagaactgga cagaacctac ctaacaacac    240
 catttaccgt gtatgttttc aatagacaaa acatattttg taccaaattc caacagtggt    300
 aattctatag ttgtggccct ttaaaaaatg gcagcattgt acttgaatca gaaagcttac    360
 tgggatttcc tcatcgaaag tagagattgc agctaatcct agtacctttt gttagtaatt    420
 acttaaggca cagtgcaaag ttgaaggact gttttggtac aaactcaagc cagctacatg    480
 tatgcttgcc ttggtatcct tgctagagca catgcaggta taataccgta ttatacacaa    540
 caaggccacc ctgttgtatc tgtgttacaa ttaaacatca gtcccagaaa gtgaacccta    600
 gtcatttatt ataggtgccc acctctgact tggaacaaaa tgccactcca ttcatgttca    660
 tttttgtcct ggagaggatt tatttcctaa aagattctga aagccaacaa atcaatgtgg    720
 ttcttcatag agaacttaag agtaaggctc aaaatggcct caaaatgggc ttcttggatg    780
 acttccaaca gtgactggcc ttctcaacac tgcagatgtc tgagcactac cataacctaa    840
 cgaagtgagg aaggaggagg caaattggta tttttaaaca agaatttaag tggctctttc    900
 tttcaagtct aaaaaaacct ttggctttaa agattataaa ctgatttact aaatttataa    960
 aagaccttaa tttagcaaag agcttctttt tcctttggtt cagttactca aaatccactg   1020
 tgtgaaggaa taatgtatcc atcattcagc ctttatagcg gtcttccggt agcgaagtac   1080
 tgtcactgtt acccatatat ttaaagccag catgatccca aaacgtagaa gaattgtaaa   1140
 atcattggtg gtcattaagg ttgtgattat tcttgttgca caggtatagg aagagaggct   1200
 ccaagtcagc gcactcacag ttcctgagtc tctcgtcttc cacagacact ggagctgtgc   1260
 aaacttactg gccgcgctga tgaaagtaca tagattcatg gccaggtcta tgatccactt   1320
 ctgcagggca aggatgaacc aagaagacac caatacagcg atgtaaggag tggcctgctt   1380
 cacgttcccg ttaaaatgaa agatacagag caggaggatg acatcttgcg cgatgaggat   1440
 ggggtactcc aggtaggtca gcggcggata cccatagtaa cactggtacc gcagaaacac   1500
 caggaatcct gccagctcca gaagtaaact cggaaggctg aggccccgcg cgctgcgcgc   1560
 cgctagcaca gcggagatct gcggcagctt cagcgcggcg cacacgccca gcgtgctcca   1620
 gttacacagc cccagcagcg ccgcctccat agcgccacgg gcgcgggcac ctgggcggcc   1680
 gcagcgagaa gggaccgctc agcctcggcg gcgcagctct gccgaagcct tccgccttcc   1740
 cgggatccgc ccgggaccac ccggccaggg ccc                                1773



      <210> 2044
      <211> 1256
      <212> DNA
      <213> Homo sapiens


      <400> 2044
 gggctatcca tgttcttatt ttagggatgg aaaagggagg gtgggtgggt gagaacacgg     60
 cagaggtggg atatgcattc tgccaatcta gatccgcagc cctgttagtc ccctagtggc    120
 catgtgggct tctctgatac acggctcagt tgggggatga gggctcgggg gtagattccc    180
 ggcttccgaa gaggcgtgag aattctgttc ccccacatca ccgcgtcctt tcttctgccc    240
 gatttccccg gaaagtgtag cagaggcgct gtgtttggaa gtcccgctat cacggccccc    300
 cagatggggc ctggacgatg cctcctgacg gccttgttgc ttctgaccct ggcgccaccg    360
 ccggaagcct cccagtactg cggccgcctt gaatactgga acccagacaa caagtgctgc    420
 agcagctgcc tgcaacgctt cgggccgccc ccctgcccgg aggccggtcc ctgccaaggg    480
 gcactgcccc ctcacacctg gaaacccagg cgcccctagc tcccaggagc gcagctcacc    540
 agcaagttcc attgcctgga ggacccctga gcctgtccct cagcaggcct ggccgaattt    600
 ccttccgctc gtggtgctgg tcctgctcct gaccttggcg gtgatagcga tcctcctgtt    660
 tattctgctc tggcatctct gctggcccaa ggagaaagcc gacccctatc cctatcctgg    720
 cttggtctgc ggagtcccca acacccacac cccttcctcc tcgcatctgt cctccccagg    780
 cgccctggag acaggggaca catggaagga ggcctcacta cttccactcc tgagcaggga    840
 actgtccagt ctggcgtcac aacccctgtc tcgcctcctg gatgagctgg aggtgctgga    900
 agagctgatt gtactgctgg accctgagcc tgggccaggt gggggtatgg cccatggcac    960
 tactcgacac ctggccgcaa gatatgggct gcctgctgcc tggtccacct ttgcctattc   1020
 gctgaggccg agtcgctcgc cgctgcgggc tctgattgag atggtggtgg caagggagcc   1080
 ctctgcctcc ctgggccagc ttggcacaca cctcgcccag ctagggcggg cagatgcatt   1140
 gcgggtgctg tccaagcttg gctcatctgg ggtttgctgg gcttaacacc caataaagaa   1200
 ctttgctgac tactaagccc agtatacaat tagcactgaa gtacttattg aagtac       1256



      <210> 2045
      <211> 1256
      <212> DNA
      <213> Homo sapiens


      <400> 2045
 gggctatcca tgttcttatt ttagggatgg aaaagggagg gtgggtgggt gagaacacgg     60
 cagaggtggg atatgcattc tgccaatcta gatccgcagc cctgttagtc ccctagtggc    120
 catgtgggct tctctgatac acggctcagt tgggggatga gggctcgggg gtagattccc    180
 ggcttccgaa gaggcgtgag aattctgttc ccccacatca ccgcgtcctt tcttctgccc    240
 gatttccccg gaaagtgtag cagaggcgct gtgtttggaa gtcccgctat cacggccccc    300
 cagatggggc ctggacgatg cctcctgacg gccttgttgc ttctgaccct ggcgccaccg    360
 ccggaagcct cccagtactg cggccgcctt gaatactgga acccagacaa caagtgctgc    420
 agcagctgcc tgcaacgctt cgggccgccc ccctgcccgg aggccggtcc ctgccaaggg    480
 gcactgcccc ctcacacctg gaaacccagg cgcccctagc tcccaggagc gcagctcacc    540
 agcaagttcc attgcctgga ggacccctga gcctgtccct cagcaggcct ggccgaattt    600
 ccttccgctc gtggtgctgg tcctgctcct gaccttggcg gtgatagcga tcctcctgtt    660
 tattctgctc tggcatctct gctggcccaa ggagaaagcc gacccctatc cctatcctgg    720
 cttggtctgc ggagtcccca acacccacac cccttcctcc tcgcatctgt cctccccagg    780
 cgccctggag acaggggaca catggaagga ggcctcacta cttccactcc tgagcaggga    840
 actgtccagt ctggcgtcac aacccctgtc tcgcctcctg gatgagctgg aggtgctgga    900
 agagctgatt gtactgctgg accctgagcc tgggccaggt gggggtatgg cccatggcac    960
 tactcgacac ctggccgcaa gatatgggct gcctgctgcc tggtccacct ttgcctattc   1020
 gctgaggccg agtcgctcgc cgctgcgggc tctgattgag atggtggtgg caagggagcc   1080
 ctctgcctcc ctgggccagc ttggcacaca cctcgcccag ctagggcggg cagatgcatt   1140
 gcgggtgctg tccaagcttg gctcatctgg ggtttgctgg gcttaacacc caataaagaa   1200
 ctttgctgac tactaagccc agtatacaat tagcactgaa gtacttattg aagtac       1256



      <210> 2046
      <211> 372
      <212> DNA
      <213> Homo sapiens


      <400> 2046
 cccgatggaa catttaaccc agccttctat ctcttgaatt taatgtgccc atcaatttat     60
 gtttaccata ataaacatga aatcacctca taatttgtag gactatgttg gatcggaaca    120
 tccaaatgta tctgacagag gcaccaaacg agctctacat atgagttagg atgttctaac    180
 ttagaagaaa caaaaagtaa gaaaatgaac tacctggagg acaactcaaa ctgtttgtca    240
 ttatacatgt aacaagcatg tataaaatgt cagattctat acatactcta aacagtactg    300
 taaacagtat catcctgctc atagatatga acctattctt taaaataatt ttagaattag    360
 catattttat tt                                                        372



      <210> 2047
      <211> 628
      <212> DNA
      <213> Homo sapiens


      <400> 2047
 ctaaattaga taagttttat ttgcttattt tatttgcttt taacacattt tgaagttatg     60
 tgtgaggtaa tttccattgt tctagtttta attcaaacaa tactgaacat acttacaata    120
 tctaaagatc tttggccttt ctttgcagaa ttaattggaa aaggtacaat aaatatgcaa    180
 tatgtcactc accattttaa tattctaaat ttagcaattg ctcttatatc taatgattaa    240
 taatataagt tgttctagtt tcctttatct gctgtggtat aaatttggct gctaatccaa    300
 taataaaact atttatattt ttaacatttt caaatatcat tactactgct atttactagt    360
 ctcagtgaca atctgagatt ctccctagat gcttaaagga ccctttttca ggggcaaaaa    420
 taaaaaattc caacgaataa aatcttaaat ggtcacaacg accacgcccc ttttaacata    480
 ataaataaat gattagcctc tgtattacta acagaaaact ccgtacttta aagctcatac    540
 cttgcaagat gttataatgc cggaagcctg tactccaccc atagagccgg gtttagggaa    600
 tcttttaaaa atacaaaatt gaatgcag                                       628



      <210> 2048
      <211> 1397
      <212> DNA
      <213> Homo sapiens


      <400> 2048
 ctcagagcgg tggaattcga acgcttttga aagcgaatca ggaaattact tatcaatctg     60
 aagccccata taattatgaa taatcctcgc tgccaaaggg aaggggattt tgagcaaaag    120
 ctccacatct gcgcacacta gagttcaaag actccagctg ttggaaggtc ttgtgagcaa    180
 gagccaaaga tgtttgtctt gctctatgtt acaagttttg ccatttgtgc cagtggacaa    240
 ccccggggta atcagttgaa aggagagaac tactccccca ggtatatctg cagcattcct    300
 ggcttgcctg gacctccagg gccccctgga gcaaatggtt cccctgggcc ccatggtcgc    360
 atcggccttc caggaagaga tggtagagac ggcaggaaag gagagaaagg tgaaaaggga    420
 actgcaggtt tgagaggtaa gactggaccg ctaggtcttg ccggtgagaa aggggaccaa    480
 ggagagactg ggaagaaagg acccatagga ccagagggag agaaaggaga agtaggtcca    540
 attggtcctc ctggaccaaa gggagacaga ggagaacaag gggacccggg gctgcctgga    600
 gtttgcagat gtggaagcat cgtgctcaaa tccgcctttt ctgttggcat cacaaccagc    660
 tacccagaag aaagactacc tattatattt aacaaggtcc tcttcaacga gggagagcac    720
 tacaaccctg ccacagggaa gttcatctgt gctttcccag ggatctatta cttttcttat    780
 gatatcacat tggctaataa gcatctggca atcggactgg tacacaatgg gcaataccgg    840
 ataaagacct tcgacgccaa cacaggaaac catgatgtgg cttcggggtc cacagtcatc    900
 tatctgcagc cagaagatga agtctggctg gagattttct tcacagacca gaatggcctc    960
 ttctcagacc caggttgggc agacagctta ttctccgggt ttctcttata cgttgacaca   1020
 gattacctag attccatatc agaagatgat gaattgtgat caggaccaag atccctgtgg   1080
 taaacactct gattgaatct ggggttccag aaggtggaac aagcaggaat gggatccaaa   1140
 gagactccca ctcagattct aaagcattta aagacaattc tagcagaatt tatcaaaaca   1200
 agatgaaaca cagaaaagtt gaaaccacaa caaaatgaat tctattaaag aatagcccca   1260
 gatataaatt ctcttgaaag caatgttcat aaatatttaa gcaaattaaa gacaatgtta   1320
 acaaattttc tattaaatgc cctgagtgat aaaaccagtt ggcaataata ttgccttatt   1380
 aaatcttcaa aaaataa                                                  1397



      <210> 2049
      <211> 1430
      <212> DNA
      <213> Homo sapiens


      <400> 2049
 catctggaga acattgtgta ctacaaggac gacacccact actttgtgat gacagccaag     60
 aagcagtgcc tgctgcggct gggggtgctg cgccaggact ggccagacac caatcggctg    120
 ctgggcagtg ccaatgtggt gcccgaggct ctgcagcgct ttacccgggc agctgctgac    180
 tttgccaccc atggcaagct cgggaaacta gagtttgccc aggatgccca tgggcagcct    240
 gatgtctctg cctttgactt cacgagcatg atgcgggcag agagttctgc tcgtgtgcaa    300
 gagaagcatg gcgcccgcct gctgctggga ctggtggggg actgcctggt ggagcccttc    360
 tggcccctgg gcactggagt ggcacggggc ttcctggcag cctttgatgc agcctggatg    420
 gtgaagcggt gggcagaggg cgctgagtcc ctagaggtgt tggctgagcg tgagagcctg    480
 taccagcttc tgtcacagac atccccagaa aacatgcatc gcaatgtggc ccagtatggg    540
 ctggacccag ccacccgcta ccccaacctg aacctccggg cagtgacccc caatcaggta    600
 cgagacctgt atgatgtgct agccaaggag cctgtgcaga ggaacaacga caagacagat    660
 acagggatgc cagccaccgg gtcggcaggc acccaggagg agctgctacg ctggtgccag    720
 gagcagacag ctgggtaccc gggagtccac gtctccgatt tgtcttcctc ctgggctgat    780
 gggctagctc tgtgtgccct ggtgtaccgg ctgcagcctg gcctgctgga accctcatag    840
 ctgcaggggc tgggagctct ggaagcaact gcttgggcac taaaggtggc agagaatgag    900
 ctgggcatca caccggtggt gtctgcacag gccgtggtag cagggagtga cccactgggc    960
 ctcattgcct acctcagcca cttccacagt gccttcaaga gcatggccca cagcccaggc   1020
 cctgtcagcc aggcctcccc agggacctcc agtgctgtat tattccttag taaacttcag   1080
 aggaccctgc agcgatcccg ggccaaggaa aatgcagagg atgctggtgg caagaagctg   1140
 cgcttggaga tggaggccga gaccccaagt actgaggtgc cacctgaccc agagcctggt   1200
 gtacccctga cacccccatc ccaacaccag gaggccggtg ctggggacct gtgtgcactt   1260
 tgtggggaac acctctatgt cctggaacgc ctctgtgtca acggccattt cttccaccgg   1320
 agctgcttcc gctgccatac ctgtgaggcc acactgtggc caggtggcta tgagcagcac   1380
 ccaggagatg gacatttcta ctacctccag cacctgcccc atcatgtatt              1430



      <210> 2050
      <211> 481
      <212> DNA
      <213> Homo sapiens


      <400> 2050
 gggagtaggg ctggactgtg accactgccc tggagagaag acagaaacag gacagaggat     60
 cccggctgca gccagcgtga ggaaagctct gctccctgcc agaccggcca gctgtggaaa    120
 cccagcgggg cttgcagcaa agcggagggg cccaccccgt tcttcctcat ttcccacccc    180
 tggtgtggga tttggggggc tcctgggcag agtgcgaagc tccggagccg aggccactgg    240
 atccccagtg actgctcggg ggggtcccgc tgcgtggaga tgccggcagc acgtcggttc    300
 cctggcctgg agctctcctt ccctctcctg gccatactgc gactacgtct cgttcacaat    360
 gctgggaggc tggtacaatg cactcagagg agggcacatg ctggctgctg gagctgctgt    420
 ccgaggtgca gctgcaacag tacttcctgc ggctacgaga tgacctcaac gtcacccgcc    480
 t                                                                    481



      <210> 2051
      <211> 488
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> misc_feature
      <222> (1)...(488)
      <223> n = a,t,c or g


      <400> 2051
 gtaagattga actcagctct aactggactc ttctgagtgt tgggtaggaa gtcgggggga     60
 gcatggctca atagggccac ccggtctcca gtgacagaag tctccggctc tggggtgatt    120
 tcaaagtgat ctaatagtgc tccaaggaag gctcttatgt cttcaaattc agcacttccc    180
 atgttccggg aggcatccag aaggaaagca gcatccatgt aagactgcac agggggtggt    240
 ctggcttggt cacaaaaagc atctggcttg cacacatctg tgaaccaaaa gttactctgg    300
 gttactaagt agaaatagaa aagggaagat agcatgtcta atattttgac atttggaaac    360
 tgcatagtct ttgatgttaa aatagtgact aaatacttta atagtaacag gaagaattct    420
 agtacatggt ttgatctgtc cccaaaagac aaaattatac cccagctgng ctgggactca    480
 ttactaag                                                             488



      <210> 2052
      <211> 2031
      <212> DNA
      <213> Homo sapiens


      <400> 2052
 gtccggaaat tctgcgaaga cccacgcgtc cgactaagct tgcctaattt gcttcagaat     60
 tggaagaggg aattgcagca ggaaaatatg tgaagagttt ttaaacccac aaattcttct    120
 tactttagaa ttagttgtta cattggcagg aaaaaataaa tgcagatgtt ggaccatgtt    180
 ggaaaccttg tcaagacagt ggattgtctc acacagaatg gaaatgtggc ttctgattct    240
 ggtggcgtat atgttccaga gaaatgtgaa ttcagtacat atgccaacta aagctgtgga    300
 cccagaagca ttcatgaata ttagtgaaat catccaacat caaggctatc cctgtgagga    360
 atatgaagtc gcaactgaag atgggtatat cctttctgtt aacaggattc ctcgaggcct    420
 agtgcaacct aagaagacag gttccaggcc tgtggtgtta ctgcagcatg gcctagttgg    480
 aggtgctagc aactggattt ccaacctgcc caacaatagc ctgggcttca ttctggcaga    540
 tgctggtttt gacgtgtgga tggggaacag caggggaaac gcctggtctc gaaaacacaa    600
 gacactctcc atagaccaag atgagttctg ggctttcagt tatgatgaga tggctaggtt    660
 tgaccttcct gcagtgataa actttatttt gcagaaaacg ggccaggaaa agatctatta    720
 tgtcggctat tcacagggca ccaccatggg ctttattgca ttttccacca tgccagagct    780
 ggctcagaaa atcaaaatgt attttgcttt agcacccata gccactgtta agcatgcaaa    840
 aagccccggg accaaatttt tgttgctgcc agatatgatg atcaagggat tgtttggcaa    900
 aaaagaattt ctgtatcaga ccagatttct cagacaactt gttatttacc tttgtggcca    960
 ggtgattctt gatcagattt gtagtaatat catgttactt ctgggtggat tcaacaccaa   1020
 caatatgaac atgagccgag caagtgtata tgctgcccac actcttgctg gaacatctgt   1080
 gcaaaatatt ctacactgga gccaggcagt gaattctggt gaactccggg catttgactg   1140
 ggggagtgag accaaaaatc tggaaaaatg caatcagcca actcctgtaa ggtacagagt   1200
 cagagatatg acggtcccta cagcaatgtg gacaggaggt caggactggc tttcaaatcc   1260
 agaagacgtg aaaatgctgc tctctgaggt gaccaacctc atctaccata agaatattcc   1320
 tgaatgggct catgtggatt tcatctgggg tttggatgct cctcaccgta tgtacaatga   1380
 aatcatccat ctgatgcatc aagaggagac acaacctttc ccaaggacgg cgtgaggccg   1440
 tattgtgaag catctgacac tgacgatctt atgacaacct cctgagggat ggggctagga   1500
 cccatgaagg cagaattatg gagagcagag acctagtata catttttcag attccctgca   1560
 cttggcacta aatccgacac ttacatttac attttttttc tgtaaattaa agtacttatt   1620
 aggtaaatag aggttttgta tgctattata tattctacca tcttgaaggg taggttttac   1680
 ctgatagcca gaaaatatct agacattctc tatatcattc aggtaaatct ctttaaaaca   1740
 cctattgttt tttctataag ccatattttt ggagcactaa agtaaaatgg caaattggga   1800
 cagatattga ggtctggagt ctgtggatta ttgttgactt tgacaaaata agctagacat   1860
 tttcaccttg ttgccacaga gacataacac tacctcagga agctgagctg ctttaaggac   1920
 aacaacaaca aaatcagtgt tacagtatgg atgaaatcta tgttaagcat tctcagaata   1980
 aggccaagtt ttatagttgc atctcaggga agaaaatttt ataggatgtt c            2031



      <210> 2053
      <211> 436
      <212> DNA
      <213> Homo sapiens


      <400> 2053
 cctgggagac aagatccatc aggggccacc aaagtaacac tctgaccaaa ataatgcagt     60
 tatttgtaca tggaactgat tagaagtaca aagattgcca catttttgat ggaagtgtgc    120
 aaagtccatg agcctggagt gaagcctctg gctcactcaa aacaggtcct ggcctggaac    180
 catccaccca caggcagcag gtgagaaagc tgagcttggc ccaagagctg cagccaaggg    240
 aatacaaaaa aggccagctc ccccccaggg ggcagagccc agagcagggc accatcaggt    300
 cctttccctc ctcaccgcaa ggcgacctca gtctgtgcgg cagcttccag cactgtgggg    360
 cagtctacca ttaaatgctc ctccaaatga agctggactg tgcggacgcg tgggtcggcc    420
 cggtaattcg aggcga                                                    436



      <210> 2054
      <211> 849
      <212> DNA
      <213> Homo sapiens


      <400> 2054
 gacccaatga tccggcctgg gccgtggctg tcactgcgtt cggacccaga cccgctgcag     60
 gcagcagcag cccccgcccg cgcagcagca tggagctctg gggggcctac ctcctcctct    120
 gcctcttctc cctcctgacc caggtcacca ccgagccacc aacccagaag cccaagaaga    180
 ttgtaaatgc caagaaagat gttgtgaaca caaagatgtt tgaggagctc aagagccgtc    240
 tggacaccct ggcccaggag gtggccctgc tgaaggagca gcaggccctg cagacggtct    300
 gcctgaaggg gaccaaggtg cacatgaaat gctttctggc cttcacccag acgaagacct    360
 tccacgaggc cagcgaggac tgcatctcgc gcgggggcac cctgagcacc cctcagactg    420
 gctcggagaa cgacgccctg tatgagtacc tgcgccagag cgtgggcaac gaggccgaga    480
 tctggctggg cctcaacgac atggcggccg agggcacctg ggtggacatg accggcgccc    540
 gcatcgccta caagaactgg gagactgaga tcaccgcgca acccgatggc ggcaagaccg    600
 agaactgcgc ggtcctgtca ggcgcggcca acggcaagtg gttcgacaag cgctgccgcg    660
 atcagctgcc ctacatctgc cagttcggga tcgtgtagcc ggcggggcgg gggccgtggg    720
 gggcctggag gagggcagga gccgcgggag gccgggagga gggtggggac cttgcagccc    780
 ccatcctctc cgtgcgcttg gagcctcttt ttgcaaataa agttggtgca gcttcgcgga    840
 aaaaaaaaa                                                            849



      <210> 2055
      <211> 780
      <212> DNA
      <213> Homo sapiens


      <400> 2055
 cggcgcggaa atcccgggtc gacgatttcg tcaggcgcct tcacgatgcc ggcggtttga     60
 gtacaagctc agcttcaaag gcccaaggct ggcattgcct ggggctggaa tacccttctg    120
 gagccatcat ggaggacttc tctcttctcc tctgcctctc cttggacccc tgcccttcct    180
 ctacctctga cctgtgaaca cacagacaca tgctcacaca ctaagtccca ggcacacaga    240
 aggcaatgtg gaccagcaca aacctccact ctcccggctc catcccagcg ggcctgtggc    300
 tggccatgag aactgggggc tacctggagg gaagcatcct catcccagac gccatcctgg    360
 gcctggagga agtgcggctg acgccatcca tgaggaaccg gagtggcgcc gtgtggagca    420
 gggcctctgt ccccttctct gcctgggaag tagaggtgca gatgagggtg acgggactgg    480
 ggcgccgggg agcccagggc atggccgtgt ggtacacccg gggcaggggc catgtaggct    540
 ctgtccttgg ggggctggct tcgtgggacg gcatcgggat cttctttgac tctccggcag    600
 aggatactca ggacagtcct gccatccgtg tgctggccag cgacgggcac atcccctctg    660
 agcagcctgg ggatggagct agccaagggc tgggctcctg tcattgggac ttccggaacc    720
 ggccacaccc cttcagagca cggatcacct actgggggca gaggctgcgc gtgagtcacc    780



      <210> 2056
      <211> 1100
      <212> DNA
      <213> Homo sapiens


      <400> 2056
 actggaaagg aaacttttct accctgagtg cgagataaga acgatgggtg gaagagagca     60
 acgccagagc ccaggcgccc agaggacttt cttccagctt ctgctgtcct tctttgtgga    120
 gagcaagctc cacgaccacg ctgcttactt agtagacaac ctgtgggact gtgcagggac    180
 tcagctgaag gactgggagg gtctgacaag cctgctgctg gagaaggacc agagcacgtg    240
 ccacatggag ccagggccag ggaccttcca cctcctaggg tgaaaccagg agggattgct    300
 tgcttcactt gtacaaggca ggaacggtgg catcgggtgg gggaaacttg gagttggaag    360
 gtggctaatc tttgattcta tgtttttgat cctcctggca ctccagacct gggtgatgtg    420
 caggagagca cactgataga aatccttgtg tccagtgccc agcaactcct gcctcagcct    480
 cccgagcagc tgggactaca ggcgcccgcc accacgcctg gctaactttt ttgtattttt    540
 ggtagagacg ggttttcacc gtgttggcca ggatggtctt gatctcttga ccttgtgatc    600
 cacctgcctc atcatcccaa agtgctggga ttacaggcgt gagccactgc gcccagcatg    660
 ttagacaatt tttaattcat cctctctgtg ctgttgtttt ctcagctgtg aaaggaatat    720
 tctggtgggg acaaggttac agagttgctg agagggtctc atgacatgaa ggtactggcc    780
 ttggcacagt gcctgggggg gcggggactc cgcacatgcc tgtgatgtca cagttactgt    840
 cagttcacag cgaaccttcc ctccttttcc tgttgacttt cccacactcc tgtaaccctc    900
 cctccctccc ttcttcctct ctctctctct cactcacgca cacgcacaca cacacacaca    960
 cacacactcc attcactgtc tccatgactc tggagtaaac taacgtctcg agttgccatt   1020
 ggaagcccca ttgtcctcat ttagactttc atgggttata ggcacttttg acttcctggg   1080
 gtccttcttc agataaaaag                                               1100



      <210> 2057
      <211> 688
      <212> DNA
      <213> Homo sapiens


      <400> 2057
 cggcacgagg catattttat attaacacta caaaatgctt atttaatttc gttttataat     60
 ttcagaataa gggtgacagc tgctagaaat tccacaatac tcaagggcca aatttagtct    120
 ttttgcctca aatagaaaga aagcatgcag gaaagcaata tatacttcct atctatctgt    180
 ttcaagacat cttggtgtct gtttttactg gcaacgggac atctttacta ctgtaattct    240
 caaacacttt ggcaatacac tgaacactgt tatgacagtt tgttctttaa cacatttgta    300
 ttatctttca gttaaaagta tgtctttatg cctacatatt tcaaagtaat atgagagaga    360
 acattaaact gtgttggatt gtgataaaat tcttggaatc ttaaacatca taatacctca    420
 ggttatttgg tcactgctct tgctagcaag gctaagtagt ttcagtcctt tagagcttta    480
 tatttaatgg aaggttaaaa acaaaaacgg gatgggaagg aacgtatcgc ctaatacata    540
 attcttggca ttagatgatt tttcctgtaa aggagctaat aagaatattc tcgtaattta    600
 ttggacatta tgattttgat atatacttac taaagataaa taaggtactt ggcccagcca    660
 gggagaggtg atacatcctt agaaagct                                       688



      <210> 2058
      <211> 369
      <212> DNA
      <213> Homo sapiens


      <400> 2058
 gaaatttaca aaaattagaa agctactaca tgaaaatata acatttatgt caaacaacag     60
 gaaatttttt tcaggagtat agataaaaag tttccagtga attttttttt ccccacagtt    120
 ttttttcttc ccacccacta ctcaaggtag ttatgaatgt tactgctatt tggttacaca    180
 gagataagtt attttgctgg ttagttattt cttatatttc tgaaatatgc ttaagtgaat    240
 gttggattaa aatagctgtc tttaaaaact ctctatttaa aaatgtctta caatactaca    300
 ttcttacaga cctgtgtctg agccaattat tgatgaataa tttgtatagt ttagaaagtt    360
 atataaaag                                                            369



      <210> 2059
      <211> 691
      <212> DNA
      <213> Homo sapiens


      <400> 2059
 ggtaatctgt gtcccttata aatggcaggc tctcttccca ctccttggct tcctttccct     60
 tattccagtc tgatgctaat ccctcttgct tcctcaggga ccttgcttca ttgtcttttc    120
 ttcagggtct caatgatcct tttctttcaa catataaaca tgcataagtc tttcatattc    180
 tttatgaaaa cagaaaacga tgaacgcttt tggtcgcttc tctctaggtt tgggaggggt    240
 catcttattc ctggtcttac caggcagctc cttgaagtac aggtcctcgt acacatcccg    300
 cacctcgcca tcttcctttc atcttcaacc ccctgcactc ctgtcctctc ctaatgacca    360
 ccaggtccat tatctaggat tctctttcat ttcttgaact ttgcacaaca tttggggttc    420
 ttgaccactc tctgctcctt aaaatgatgc ccacctgttt tctgaggtat ccatttctcc    480
 tcattttctt tcttgcccag ctgctctata tttggacttc tctttactgt cctcccttcc    540
 tctcaaacct tagcctcccc tacagttcag ccctcagccc tctgctcatt ctgcacgttt    600
 gccctgtggc agctcatctt ctgttttctt ctactaccac ctatatgcca ttgattccat    660
 tggaaatctg catctccagc cttgaaatct a                                   691



      <210> 2060
      <211> 693
      <212> DNA
      <213> Homo sapiens


      <400> 2060
 gtcagggctg tgcttggact tggaattgaa ataagtcctg gaaaattggt taatccccgc     60
 ttggcataca tattatgtaa agtgtgttgg gagaggtact tgaaggtttt cctgttgaaa    120
 taaattccct acaaccttag ccttccagtc cctctgcctg acactcccat ggcagttggt    180
 gcacttgcgt tttgccctgt tgaagatgcc tgtgccatta gctcgcattt gttgggtatc    240
 tttcttgcac caggcaccat gctgggaact atgctattac tgcgtggtcc tcacatcagc    300
 tctgataggt gctgttaata gctccatctt acagatgact ggatctacag ggagattaga    360
 cagttggcca tggtgacagt gaacttagtt cttgggtcat tgctcctgga gcctatgcat    420
 tatagacctg ctggtgtgag ctctttctcc tcattcatct gagaagactt ctgtgtctgc    480
 atttgcctct tcctatgtta gtaaaaggaa catttttcca ctggaaaaca gttaccaaca    540
 gttttgtcag tggctactct attatacctt caaacatgcc taaatcttat gtaactcaac    600
 acccagctaa tcttgctatc tattctagcc actcttcttg gttttctctc tttaaactcc    660
 ccaacaggca ggctgtttcc attgcctcca cca                                 693



      <210> 2061
      <211> 694
      <212> DNA
      <213> Homo sapiens


      <400> 2061
 ctttcagttc ccgtcgtgag aagaagctga accggaagtt ggtaagccga ggtctgccca     60
 ccatggtact gtgttcttca gccttcttaa ctgtgcagtg gggaggagag gcatcagata    120
 atatttacct tgctttctac ttttcagtct gtggttttac aatctccctg actctcaccc    180
 catccaggca tctgaaaggt tgtgtggaag caaggttgag tgagagtggg gagggggaga    240
 aagggtggca ggagggtttg gtttctgggg cctgagtaac tctggccttg aacattcccg    300
 cgatcccgac agattcccag gtggaataaa gacctggggg ccccagtggc tgctagaaag    360
 ggctgaccag gggtcttccc cttttgacta acatgtgttg gaaatatggg gtctgtgata    420
 tataaggaat ttctctctcc ctctgtctac tgggaagata ttcgccatat tatatggaga    480
 ccctcactgg agtagaaaat gaaaaggctt tgaggacaag ttacttccat gtttttatcg    540
 aggaaactaa actgtctgca gccatggtta tatgtctcca ccaagatgta cacctcacgc    600
 attctccttt ttctgtggtt gggtgtattt tcttgcctag aaatactctg agctggaacc    660
 acagcggggc tcctgcaagt tcggatatta attt                                694



      <210> 2062
      <211> 331
      <212> DNA
      <213> Homo sapiens


      <400> 2062
 actgcaccgg agtgagcgcg accatcatgt ccatgctcgt ggtctttctc ttgctgtggg     60
 gtgtcacctg gggcccagtg acagaagcag ccatatttta tgagacgcag cccagcctgt    120
 gggcagagtc cgaatcactg ctgaaaccct tggccaaatt aatgacatat ttcaaaaact    180
 caacatattt gatcaggctt tttatgatct atcgctgcaa accagtgaaa tcaaagaaga    240
 agaaaaggaa ctgagaagaa ctacatataa actaccagtc aaaaatgaag aggtaaagaa    300
 tatgtcactt gaactcaact cataacttga g                                   331



      <210> 2063
      <211> 459
      <212> DNA
      <213> Homo sapiens


      <400> 2063
 cagcatacca gcttaattgg ccgccctaat tggaaaaaga ccctccaggc cgccaatact     60
 gcacgagggg gcgagcattt ttgaggacag gttttccgca gagcgcctag gcccggccca    120
 ggcatttcct tattttccga cgggtcctcg gattcctgac ggatgagctt ttgtttcgca    180
 ggacaaaaac ttgacataac tgcataagaa ttgtcgattg caactttaaa aaccttactg    240
 tattttctga aaagtggggc tgtaaagcat ctaggctttt actacgctct taaattgctt    300
 aaatatggag ataacaaaga gttggtttgt tttcttgtgg cttataaagt tccttgaaaa    360
 cagagatacc tatgtcagtt tctttgctga tttaaaaaaa attgtaagag aaattaggtg    420
 tgtaataatc atcagttcag cacttgcgag aattatgaa                           459



      <210> 2064
      <211> 348
      <212> DNA
      <213> Homo sapiens


      <400> 2064
 cggcacgagg tgattaagta ataagaaaga cagtgatggg atcagtagca cagagtctca     60
 tcgttttgtg atttcatgtc tgtgtttttc ttgtcttgcc tgatcttacc ccaaccagga    120
 cccattgctg ccggagtgag gtgttactcc tggacccctc cgctggtccg tggagacttg    180
 gctggcaaag ttgcatgtga cgtacatcct tagttccctg agtggcctca tgcaggagct    240
 gcatagggtt actctgattt tgggatatcc cgtgaataat cacaagtggc attttctctt    300
 tcattacctg tgtaatgtat aaggagactt caaaacggtt gtggaaaa                 348



      <210> 2065
      <211> 793
      <212> DNA
      <213> Homo sapiens


      <400> 2065
 gatgaataat gtacactttt aatttaatga aatcaaatag attttaacta tctatgctta     60
 caatgggggg acataagtct gacaatcctt aatatcaagt catctccaat tcacatgtat    120
 acacactttt tttctatttg gctattggga atcctcacaa aaatcgaaaa ttgccctttc    180
 agtgtacgtt acggtatttc atgccacaca gattttctga ggttgtacat acagctttgc    240
 cttgaggttc caatttttgc tcagtggatt gagaatatat tatttgctat atatcagaag    300
 aggcatgtgc ttcctactta tgtcaggtaa ctttgggatt aataattgtc ctacaaagca    360
 tagatagata gaaatacttc atccttaatt tctaatatta tgacatatct aaagtaggca    420
 cctttaaaag ttaatctcca ctaaatacta atgactgctt atagtggcaa ttcatctttc    480
 atggtagtcc tcctacaaag gtatactaac atttatgagt ttgaaacaaa ggcaattcac    540
 aagtgttctg ctagagatgg tctatatctg ctgtctgatc cagcatgatg gccagctggc    600
 cctcctgtgc atgacggctc gcggtttaac tgcaccattt cgttggccat aaccagggaa    660
 aacatggcat ggtgtggagg gcatgggctt gaaattacgg aacagagagg tggtcttctc    720
 tctctcactc tactggagga ggcatctccc ctttttaaca tgagttttct tactgggaat    780
 aacaacgcga aac                                                       793



      <210> 2066
      <211> 433
      <212> DNA
      <213> Homo sapiens


      <400> 2066
 cttatttgtc tgtgtgtcct tggacaagct acttagcttc tatgctaagt ttcctcatac     60
 ttacagagtt ggtttgagtg ttaaatagga tcatgcctat aaaacactta ggtcatcacc    120
 ttgcatagag catatgtcag tgaaaattaa cttaaattgt tatttttatt attagcagat    180
 ttttttcagc ctgcacgtgt acatccatgc attgcacatt cctttctgtt cttgccctcc    240
 ctgtcattgt gaggatactg aaaagttggt cttcctgtct ctgggaaggc aatttagtcc    300
 atgtaaaatg tctcaaattc cctgtcctgt cacatggctc atgaactgcc tctggcttct    360
 gaaggagcct gaaggagttg tcaaacctgc cgcagagtgc tgacgatatg tcagtgtagg    420
 ttcatccatt gta                                                       433



      <210> 2067
      <211> 433
      <212> DNA
      <213> Homo sapiens


      <400> 2067
 cttatttgtc tgtgtgtcct tggacaagct acttagcttc tatgctaagt ttcctcatac     60
 ttacagagtt ggtttgagtg ttaaatagga tcatgcctat aaaacactta ggtcatcacc    120
 ttgcatagag catatgtcag tgaaaattaa cttaaattgt tatttttatt attagcagat    180
 ttttttcagc ctgcacgtgt acatccatgc attgcacatt cctttctgtt cttgccctcc    240
 ctgtcattgt gaggatactg aaaagttggt cttcctgtct ctgggaaggc aatttagtcc    300
 atgtaaaatg tctcaaattc cctgtcctgt cacatggctc atgaactgcc tctggcttct    360
 gaaggagcct gaaggagttg tcaaacctgc cgcagagtgc tgacgatatg tcagtgtagg    420
 ttcatccatt gta                                                       433



      <210> 2068
      <211> 749
      <212> DNA
      <213> Homo sapiens


      <400> 2068
 ctaaggtatt cggccctcta gtgcgcagaa ttcgcgctcg agccccaaat cactacttgt     60
 ggtgctttca cagtcactca ccgacatgga cagagcgggg ggatttttga gttgaccagt    120
 gcacacgttc ccagctgagg ctgagcgaag cagtgctctg ctttcttgtt tcagctctta    180
 tattatatgc atgtcctttt cacactgtat ttagtgccat gttgtttgca ttttgagctt    240
 tttattggtg atcttgctgt taaaaatggc accaagcata gcgctgaagt gctatctaga    300
 gtccctaagc acaagaaggc tgtgaggtga cttaaggaga aaatatgtgt caggtaagtt    360
 tacaccagca tgagtcatag tactgttggc cctgagttca aggaatcaac catatgtatt    420
 tacagaaggt atggttaaac agaaacacac ctacaacaag gtcatgtatt aatccattga    480
 ggaaaatgtt gtggccaaag gcttgcagga acctaacctt gaatttcccc tacgagcaat    540
 ggttcaggat actctaactt ggtttcgaag aaacttagta ctatgaatag catgtattcg    600
 tagtaggata aatgggccta tttgaaggag aagaagaagt ccactgatcc cttttacatt    660
 tttttttttg tgttttcacg gacccatcac tgaaaggttg gccggggact taatcggcac    720
 cataaccctt aagggggaca aggggcctt                                      749



      <210> 2069
      <211> 710
      <212> DNA
      <213> Homo sapiens


      <400> 2069
 acaaattact ttatccctgg tgcctcagtt tcctgctttt taacatgagg atgaatttgt     60
 atcaggtaaa gtgaatacaa caccagagac aaatcccaga cacacttaaa attctcttac    120
 aaaggattat gaaacactga ctcttcctgg cacatgtcac gttcttttgc cattgactgt    180
 tgaatgacat ctgtcttccc cactagttca ggctcagtga gatcaggaac atggcatgtt    240
 cgctttcgtg tctctcatga ccagaacatg tacagcactg ttccgtggta agcaggacca    300
 tgaaaaccta accccaaagg ccaagggagc tgagaggctg aagaaagagg ctcccaaatc    360
 cagtttctcg gaaaaacaaa caaacaaaca aacaaacaaa aaacacttca tagggactta    420
 caaacagaat gcatgtcttg ggtggaggtg agacagggga tccctgtgcc attaccttcc    480
 agatccaggg cttacatact ggagggaatt tgacccaagg ccaggattta tggggtgcgc    540
 atgaaagtgg gaatctttta ggatttccac aaacgggggt ttcataagaa tcatggggga    600
 atgtggttcc ccgaggggga attttatttt tctcagacac ttattataac ccctgggggg    660
 taattccatc ttttgagggc ggcaccacac gcccacaaat agtttcccaa               710



      <210> 2070
      <211> 694
      <212> DNA
      <213> Homo sapiens


      <400> 2070
 ttcaataccc tgtctctaaa aaaaattaac aataacaaat aaaattaaat tgtcctgtta     60
 ttattccacg taaggaggat gtccattaga acaagggaga ctagtccagc tccttatact    120
 catgggaagg ctgtttccat tagtattgct tttgttccca gtaactaact ctgtttcacc    180
 tactgcactg ttggtgctgg tcaccacagg tggctctgga cctgccacca tggtcctcct    240
 gcccgcacca gtgatgggca gaattccaaa ccattgcctc tctaagtcat ctcgccagag    300
 ccccagtccc agatgtgaca aacctgaagt cccatgagtg tgcctacttg ctggcagaca    360
 tcaagaaaaa cacaaaagtg ggcatttctg cttgggaagt taaaagaaat gacactttta    420
 tccacccagc ttcacacaat gacgaatgcc cccaaattca ggaaaaggat tcagatacca    480
 ggtagcccaa atggggataa atgtctactg tacacacaat aaaatgttaa ttcaaactgg    540
 cacatggacc cctgccgctt gtcaggggat atgggccata atgaaaggga ggggagctgg    600
 aagattatgg ggaaacaatt ttcttttcca cgcattcact aaggactcct gtccataaaa    660
 atctcccacg atttataggg taaaccaggc tttg                                694



      <210> 2071
      <211> 1441
      <212> DNA
      <213> Homo sapiens


      <400> 2071
 gttaagatgg aatagtttta ttcagcaaac aaaaaacttg ctaattcaga gtatcctcta     60
 gtccaccgta atgtgggttt agactacatt tgcaaaatta gggccttgac ggctgaacaa    120
 aataaaatcc agaggaagaa ctacagtatc caatcaaaaa ggaagtacta gcaaatgaac    180
 cagaataaaa gactttattg tattccatac attcacaggt cacttccaga tttagtaaca    240
 acactgcaat gctatgatgc tgtgcggtca tttagcttaa accacagtgt aagttggtag    300
 ctctctcctg ctctcttggc ctctagatgt atcacaatac aattcctaac tgtggcctgg    360
 caaccaatgc ttatttcatt ggattatttt ctgactggga catgagttca tcgcatcttc    420
 ccagaatttt aaagtacctt cccttacatt ataagagatg accaaacact ctagtgtgag    480
 ggctgcttca cacactgttc ttatctatca tgattgctct tccttacata cacgtcccgt    540
 acagatcagc tacacacggc atggtcctga aaccacagct tttgtttctt tggccagaat    600
 gcacccctca ccttgagtgc ccgccttaga aacacaggta cttggttctc acagggtgtg    660
 catggttgac acaagttcat ctgccccacg gtaaaagctc ttcaaaacct ttgcatgact    720
 tgtggggagc agggtcacaa tttgttgcat gtgacctgcc tcagcctcaa aagataagag    780
 atcatgaggc tccaccgccc ccgggctcag gaaacttgat ccacatcgct agggctctgc    840
 ctgttaggtt atggatgctc acctgactct ctgaagcaga gggaggctga cacagattag    900
 cttttattga aattattaaa gtgcaacttt gtgttttcac tctatcaggc actgaaaagc    960
 aagaagcttt taattttttc ttttctataa tgaaatatat tttctttact cttatttgta   1020
 tctgtaatac acctgcaatt agaaacagca gttaaacata aaacaaagaa cagagcagaa   1080
 ggcacagtct aaagagtggg tatcagaaga attttaccat ttacgctcat aggaatacta   1140
 aaccaaaccc aatcagacca aactccaaag cccattgtgt ttacaagtct gcctcttttg   1200
 tgtgatagca agtcagtcct ttaaagcaga aaccccattt actaacccta catcccaagt   1260
 aagcaggcct gtatcagaac caaacagctg tcctcttaca tcagaaaatc taagtgatct   1320
 gaaagacaat tcatcacaag tgtttccaat tttcttctga gaacatcacc aatcccacta   1380
 atgcaaactc agaacattac ttcagtcaaa tttcgctaaa tgctatagct ttcttcaaat   1440
 a                                                                   1441



      <210> 2072
      <211> 857
      <212> DNA
      <213> Homo sapiens


      <400> 2072
 ggggataaca gcagtatcgg ccttgtgtag aatcactcgc cattctccta ctgccttcca     60
 aaatgttatt gaaaaggtgg gactgaactc agtaataaac tccctggcct ctgccatctg    120
 caaagttcag cagtacatgt tgaccttatt cgctgccatg ttgtcctgtg ggattcatct    180
 tcaaagacta atccaagaaa agggttttgt ctccacaatt atccgtttac ttgacagccc    240
 ctcaacatgc attagagcaa aagccttcct ggttcttcta tatattttga tttataaccg    300
 tgagatgttg ctgctcagtt gccaagcaag actggtgatg tacatcgaga gagacagcag    360
 aaagaccact ccaggcaagg agcagcaaag tggcaatgaa tacctgtcca aatgcctgga    420
 tcttctcatc tgtcacattg tgcaggagct gccacgaatc ctgggtgaca ttcttaactc    480
 cttggctaat gtttctggac gtaaacaccc atcaacagtt caagtgaaac agctgaagtt    540
 gtgtctcccc ctgatgcctg tagtgcttca cctcgtaact tcacaggtat ttcgaactca    600
 agttgggaac aaaagagttt ctttttaact atggaactat tcttaatcat attaaatctg    660
 tagactcagg aagaaacgaa ccttgatggg gcccctatgg actggcaccc tttccaaaaa    720
 atttattcaa gaaacacctt tgcaactttt ttgaacccat taatcccagt ttcctatttt    780
 tattgaaaag actattcctt cccacggtgg tggactatat actgggcccc ccttggggcc    840
 cctggtttca aaaaccc                                                   857



      <210> 2073
      <211> 496
      <212> DNA
      <213> Homo sapiens


      <400> 2073
 aatacagccc tggtctaaat gaaatcgaag agttcttatt aattattcat aatgccatga     60
 atatgttacc ttatttttta taattgccag tctgtataat taacctttca tttggttaaa    120
 gtacttaaca ttaagtagag ctataattac aactgttttt aaaagtatat ggaagaatgt    180
 ttaaatgttt aattagaacc acttttttta gcttcataaa gaattttttt tacttgtcaa    240
 caaggatctt taattattta aaccaaaaga gcagaacaga ccagaaaaga aaaacaacta    300
 gtcaagctgg gaactgcaat ggtggcgtcg ttccgtgagt ctcgggtttt gcttcttggg    360
 cttgtggtca gagtccttac ctttgatttc ctaacacagg ttgttagagt tggaagtgag    420
 tgtggagatg agttagtccg actttattct ttcacggatg agaaagcgaa ttatcttcag    480
 caaggtgggt gcaggg                                                    496



      <210> 2074
      <211> 1154
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> misc_feature
      <222> (1)...(1154)
      <223> n = a,t,c or g


      <400> 2074
 gaattcccgg gtcgacgatt tcgttggagg cctgacccta catgactaat atttctgtcc     60
 tcatttcctt atgggcctcc ctgtaatgtt atgtttccct ctaacatgag tatgtgctgc    120
 ttactggaag cacatgagtg aatttctttg tttcttcacc caaagagcca tagtaacaac    180
 tttttctcta tccactacgg agggtaacag ctgtgccaca tggctctgtg tccctttccc    240
 tgggtgctca gttttgtggt cagtacttga ccgcaaataa atgaacctct tacccaaggt    300
 tgagatggag aatgaggagg gataaagagc tggcaaaata ttgtgtagaa acaggaattg    360
 atgagatcag aatagatttt gatctttcac agagagtaaa acatttcatc ctctgtttct    420
 aaggtggtgt ccttaaggtt gtgatgcaga attcagaaga gtgtttgatg gaccatgttt    480
 gtgttgggct tgatttcata tttagtgaga taaatggcta cataaaaaca ttgacttaaa    540
 actgacgtga gcagatggta gagaatattc tattatttca aattttaaaa tagtgaaaca    600
 gattaataag gtctagggtt tcttccctga gaatcttaac aaacaagtat cagtgacaaa    660
 cagaatgtta agtgtagtga aagaggtata tgaactgtct atcttagaaa cagaagatgg    720
 ttcaactgtt tggcctatat catgaaaact gggatcaagg gagaaaatga gctgataact    780
 ttttggcaga aggtgagcct acttctggac ccgggctttt ccaagctaac tcagtgaccc    840
 acacattaca agaatcactt cgcaccgccc ctcccggggn atcacatgtc cccagacacg    900
 tccgcggggc cgcgaacgag ccacgatgta aacacatcac cggtgggcgc ctcctccgac    960
 tccgagacca gaaccatcct cggcccctgc ggcgggccat gtacagaata acaacaccgt   1020
 tctccacgac cgcgtggggc acacgttcgc gtcacattaa ccaacttcgc gcggcggcgc   1080
 caggcgcgaa ccatcgtcct agcgaacctc gccgccggct cattttcacg ccgaccccgc   1140
 gccccagctc gccc                                                     1154



      <210> 2075
      <211> 1146
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> misc_feature
      <222> (1)...(1146)
      <223> n = a,t,c or g


      <400> 2075
 cccgttcgac gatttcgtag cacaggagat tagaaccaag ttttgagcag cagcaagacg     60
 ctggaaataa agtgcatcct agtgtctaat tcaaacagat catcacggtg tggtttcaac    120
 agaacatttt cccttccttt cttgcatggg attcttatgt gaaataggag caattcctac    180
 aatggtgctg gccctctggg ggtttcttag ggccagctct gcctctccgc cttctctgaa    240
 caggctgcct gggcagggct ctgctttctc atttcagatc tgctaacttc acatgtcacc    300
 tactgccgag tcactttcct gatggactca tgggactttt ctgcatgcta tttctacaaa    360
 ttcattctct ctccacgtag gacaaaaaac atgcttggca tgtgctttgt ggagtgcggg    420
 ggtgctgggg tagggaggct ggttagtcag aagcagctgt tgagtgagct tgaacattcc    480
 tggagacttg aggtagctcc atgattttac ccatctgtca caccctcctg ggcatgtgac    540
 ctccagattc tgagttgacc ctcatgcggg agagagatct gtgtttcggt gaagcagccc    600
 tggaaactac ctccttcctg agggaaaccc ttgatctttt cgggaatggg ctctaacccc    660
 cattgcctct ctattcctcg gggtgtttac cccacccacc tttgataccg ggaccggcca    720
 gacgccggca accgaaacca gtaggctggc cccggccgtt cctcacctcg atgttcggcg    780
 gccacggatg cgtgtggctt gcgcccgggc gaccatccct ccttcatatg ccgggcccgc    840
 tgcccgcanc gcttgggcga ccgcctcggc ccggggtcgg acgcgcacaa cttaaacgca    900
 ccgcacggag ctcaagcgct ggtcgcagcc gcgactatcc gcaggccccg ggccgcggag    960
 cgctctccgt cggcttcatc cgggcgcgcc ggagtctcgc gtcccagcaa cgccccgccc   1020
 gcgctactca cgaccgcgcc ctcgacgggg cagcacgact cccagatcgg cgccctgacg   1080
 gcgaccctcg ggaatcccga cacctgcccc tcctcggtgc gcgcgtgccc gaccgcctct   1140
 ctgccg                                                              1146



      <210> 2076
      <211> 853
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> misc_feature
      <222> (1)...(853)
      <223> n = a,t,c or g


      <400> 2076
 cgctacgaga ttttgttgaa tttatcttct cttttctgct aaaaataagt ctatgagtca     60
 acatttcaca taactcatat tgttttctct ctgaagattt taaaagacat caaatttcat    120
 ttttattgat gtttattttt aaaacgaaag gaatcctttt gccctgtcaa aagatgctac    180
 aaatagtatt cttttttctt cctaaaaata ctttgtcctc aatgttttat ttttcagatt    240
 gcataggagt acataagtat atgcatattt taatttatat acatacatat gtatcactgt    300
 aacttggaaa ttaagaatgt catagaagaa tagttaaagg caatgagaaa gtgttgatga    360
 aaaaggagga gcctatgggg aaacaaaata attatatgca aatacccgaa ggtaagaaat    420
 atggaaaagg caattgtctt gctctaggtt gtcacagaca agagaattgt actaattggg    480
 taagaaataa attgcatgtg agttttttaa aaatatttct attaaaaagt taaagatcat    540
 tttttctatc atatcattga cctccttttt acaatagcta tggattatta tttcacctct    600
 attttcaaga aaaattagta aaagttaaag attatatcaa cagcttcatg gaggtagctg    660
 attttgctta tatacaccct tattacggta cttggattaa taaatggctt ctagttttct    720
 gaaacagttt acaaatatgc ccatattaat aaataatttg ctataattcc attaacattt    780
 tttacaatat ctttatgcca ccaggatatc atttctttan nnntggaaag gcgcggaatt    840
 aaaccttctt gaa                                                       853



      <210> 2077
      <211> 453
      <212> DNA
      <213> Homo sapiens


      <400> 2077
 tcgctgcagg aattcggcac gagcaccttc ttactttatg aaagcgctgt gttatgtcct     60
 ttctaagatg cacctttttt ttcatacttt aacatctcta agattgggat gcatcataca    120
 gtctctgttg gcaagggggg cctcatgctg ttactgccat cacatgaaca tcagaatttg    180
 cgagtggatg tcagcagctc agaaggaaat cccagagata gtagtagagc atccttgatg    240
 ctggagaagc ccaggctgtg tggaatagca cagcattaaa aactccatga tagagagatt    300
 aagagacatt ggactcgaaa tgtgaaaagg aataccttaa acaatttatt tcaattatat    360
 tttccttttt aaaaatttac aaaagtgata gatgcttttt taaaatctgg atctaatata    420
 ttctaaaaga gttctttcag taagtacaaa aaa                                 453



      <210> 2078
      <211> 1101
      <212> DNA
      <213> Homo sapiens


      <400> 2078
 aattcggcac gagcagctta cttgtagagt ccccccttgg ggctttctgg aagcctccag     60
 aggcctccca tgtgtttgag aagaactctt ctttggcacc ttcacatcgc accccttgtt    120
 aatattctct ctgactacaa gccactggga aggtggaacc atgccccggc ccttacagct    180
 ggagccctcc acaagaccac cattcttctg ccccagggtc atcccaaagc tgcaaaccct    240
 taatcactgc actgtctaca gtgtaccata aacatgctgt ttcctagaga agggaagaga    300
 aggagcctca ccttgactcc atgctaacct tgattcctag gccccaaagc agcactgctt    360
 gggtccacta tttaatagct tcttcagctt cccaataagg ctcagagctg accctgggcc    420
 caggcaggag agcaaacctt cctatccctt ctgggtatcc tttgctgtgt aacaaactat    480
 cctaaaactt aaaggcttaa aataacaacc atgtgttatt tttcataatt ctgtgggttg    540
 actgggcagc tctggaagtt ctgctcaagg tctcttatga ggctttaacc gcatgggggc    600
 tggagctctt gggtggggct aaaacatcga agaaggcttt actcctgggg tgagggcctt    660
 cacaggggta attggaaagc tgggaccggt tggtctcctg ggggggtttc ccttaggcaa    720
 gttagacttc ttttcagaaa ggtgggagtc agagcgatca ctagggagga gcacaaacac    780
 cagcgtgttc ggatgtgggc gctatagacc agtggaggat ggagggagaa gggggcggga    840
 tgcgtctgaa gtgagggcaa agaggaaacc gtgttttgac cggtcgagag ggagagaggc    900
 tgagtggggc gaacgagttt acaattgtgg ggggcggggc ggcaggcgat ggagggagtg    960
 ctggggacga cgggcagacg gttgagggtg agaccgcctc gggcgggtgg ggacaggata   1020
 agatggtcag gaacggcgac gctgtactat ggggggcggg ggaggagggc ctgagtggtc   1080
 aaggagcgta gaggcacagc g                                             1101



      <210> 2079
      <211> 1077
      <212> DNA
      <213> Homo sapiens


      <400> 2079
 atatccgcac cagatatgct tggcctgctt gcaccacgca gatacttaag tggataaaca     60
 gtgacagatg taagtgcata ggactaccta cactatgtgg ctggtaggaa cactaataaa    120
 ctatctgaag aggacatctg cttctcagct cctcatgact tctgtcattt agaaatgtgg    180
 gcaagtattt cctgacttga tatgttatta agaaaaactg gaaatataga ttttttatta    240
 attttaaatt ttctgaaata tgcggcaaca gacacggtat aaatctagct tggaatgtta    300
 gttttcaatc tttctcttgt tctcagtcat agtgtcctag aatttgtaat gttcctgtat    360
 agtcttgata gctctcatgt ctgccctctg gttgtccctg tcactctgga tttaatctac    420
 ttggtttatc taccttgtca gtcttacata ttgatctgaa tgttatttat ttttttcctg    480
 agtctacaca atgcctttcc tagacattta cttcttagct ttcattctat tgcattggta    540
 cagtttaaac tatacttttt taaagctcaa tttccatctt tttataataa gcttgctaac    600
 tcagaagcca cacgttacca aagatgtatt ttttagcaca cacttaaaaa tacagaattg    660
 gacctttctt gagatttaaa cttactttta taatgggggc ctgcaaaccc gaatgacctg    720
 tctgcctact tctaaccgcc cccctttacc taaccctttc taaaagcaac ctccccctct    780
 cagccaaccc acccaccggg cccacacaac ccacccgcgc attcaagttc tccccgagca    840
 cctcccgaga aacatcggac ccgctggtcc cctcccggtc gcccgcttat ccacacgacg    900
 ctccccctgc cctccttacc ctccctcccg gtcatctacg cgccgaccac ctatacgtac    960
 aagttctacc ccgccacaca ctcgcagttc cattcaggct acgcctgtcc gtctcgcccg   1020
 ccccgtcccc ctactctcgt ccctaagtca actctccagt cgtcatccgt atgaggc      1077



      <210> 2080
      <211> 965
      <212> DNA
      <213> Homo sapiens


      <400> 2080
 actgacttgt ggccttcact gtggagcagt tagtatcttt atgtctttgc tggaactgtt     60
 aattttttcc agagaaaact ctagtctcct gactgaaggg tatgggtgta aaaccatctt    120
 catctaaaat gaagtaagca ttttagagct aaattagaga agggataatt ccccattttt    180
 cattccatgc ctcactctgt ccttctttat gcccaatgtc cctgaatcca gaatttctct    240
 ggcttaagtg gtttagtctc ttgttgaggg ggagaaggaa tagttgcctg attgcattga    300
 agggatatca ttcagtaatg attttccatc tgcccctcat cccttcctct gttacctcct    360
 gtcactgagt ctttagagtt ccacagagaa aatctgcttg tatctagtct ctgaaaactt    420
 tcaggtttgg ccttctttct ctctgttaaa ccttgctgcc atctgctttc tgtttttgca    480
 tattatgatg tctccccatt ccagtgaaca tggagttttt gtatctgttt cttgttggat    540
 tggagtggtt ttaagatata gagggagaag acatgtcttt atgctgctgt cttcaaatct    600
 agcagtagct cttaatgagc acatattctg ggtgactccg agagaacaac ttcgttcgaa    660
 caatttttgt catggggcgg ttctcagcca ctgaaacccc actagaaagg aattaatata    720
 tatacttgag cagacattgg cctaaggttt gcccttcttg gggtaatagg caatattaca    780
 ggtccgttcc cggggacggg gagcgccctc cgggacccac aagaccccct gaattctggc    840
 cgcgttggcg gggcggtaaa cgagactccc tcgtcccctc cctcagattg gggacacgcc    900
 ctttcccagg tctgcgcccc ctcgggtgtg aggggggggg gcgccccccc ccccccccgc    960
 ccccg                                                                965



      <210> 2081
      <211> 889
      <212> DNA
      <213> Homo sapiens


      <400> 2081
 cctgtggtgg aattccactg gagagggcac tgacaggagg tcagcctaag gacctgctcc     60
 cgtgtgttct gtcaccagcc tacgtctgac ttccccatgg acttcaaggt ccaattgcct    120
 tagctggaag ccactgggga tgggactgaa catccctggg ctttggtctt tgtcatcagt    180
 cctcagtttg actggactca catctcctgt agtctttctg ggttcaagag aacaaaatcc    240
 gctggccaag aggttggccc ttaaggagct cctccccttc acacactccc agcagagctc    300
 ctcagagctg cccttgagac cccccagggc agcgcgaagg ccctgccagc ctaactctgt    360
 gggaggaaca ggacatgcag ctagatgcta gaggctggct ctaggacaag tgaggttcct    420
 gagctgcaga atggctccag cctcaggccc agaacagcct ggttcaccag ccggtgctga    480
 ttaaatccag agaagagacc cccatcgaaa ggcacacgtc agagaccctc caggcccaag    540
 ggactctctg agtttgggga aaataaggcc ggccggaaaa aaccacaaac cagagtccaa    600
 cgggcctgca aggcctaaga tggtcttaac tggggacgcg gccgcacggg ctcacccccg    660
 gctcagtggc ccgcacagcc ccagactggc gcccacacat aactgcgacc aggcccgcgg    720
 gccgggcccc caccccagcg cggcgccccc gccccccact caccttcagg atcgcctccc    780
 acttcgcatc ttcaacctac tccaatcctc gcccctcccc gccctgtaac cacccctcgg    840
 tccacccctc ccgctcgccc cctccgtctc ttcctcaact cgcagaacc                889



      <210> 2082
      <211> 876
      <212> DNA
      <213> Homo sapiens


      <400> 2082
 acatcatacg ccagcttgga cgaggggaga gaggttgtgc ccgaaggtgg acactggggt     60
 atgctccctc caccacctca tcctccactg ctatcctcag tacagctgct tctggtaagc    120
 gtgcaggcca tggacgccac cctcgatctg ggctgacatg gtccacttct caaatttgag    180
 ctctcctgag tacatcatgg agccatgctg gttactcgct atgaggtagg gcacaaactt    240
 ctgaatggac cctttgtcct ggatggaggc cgagacaccc tgcacaatat tcaccttttc    300
 cccctcgctg aagtatcgtt tctggctgct gctgctcttc tccatggcat ctagcgagcc    360
 catgccccag tacttcttga gctgcaccct gtctgagaag aagtactcgc cgctgggcct    420
 ccgtggtggt ggccagcagg gagcccatca tcactgtgga ggctccaagg gccagggcct    480
 tgaccacgtg ccccacggtc tggatgccac atcggctatg atggacacac caaagtgctg    540
 agcgtacttg gccaccttgt acacagcagt gccctggggc tgaccgcagg ccatcacttc    600
 ctgggtgatg cagatagagc tgcagcccat aactacatgc agtccatcca caccagtgtc    660
 aatcaggttc ttagcctggg ctgctgtcac cacattcctc ccaatcacct ggaggtggag    720
 gaacttttgt ttgatggaat gcaccatggt gatttgatac accgagttcc cttgggagga    780
 gtccaaaact atgacgttga tgcctaccca ggtggaacag gtccaggcag aatttgtcat    840
 cctcatgggt ggccacagct gccctgcaca acaagt                              876



      <210> 2083
      <211> 970
      <212> DNA
      <213> Homo sapiens


      <400> 2083
 acattagcat gattacccag cttggcacga ggcctcagca tatgctctgc ctcacttgct     60
 tcctcactgt taaaatgaca acggacgccg tcttcggtgc ttccaacacc ctcggttccc    120
 tctcgcggcc cggccttcct acgctgctac gttgtgcatt acccacaaca gcaaaaatgt    180
 tccactggtg gtttcaagat tcctaaaaaa atagattcaa aacatcttta atactctctg    240
 aagaagcaat acatcacagg aaaagctgta acctttcctg ttgctgatac tatccagact    300
 gcgggctgat gaggacggta actgcagcca attcgtattc tgcgtggctg ccgctggagg    360
 tgcacaggag ctggtccacc caccctccac actcccaacc aaggaagctg ctgaatttct    420
 gagtgtttgc ctaatgccct tttatataac ctgaaaagag tcacagtact tgaaggcagt    480
 attttccaag aaacagcctt cccctattaa cgcaacatcc ctgaaaataa tactgctgtt    540
 tctacggcag tgacaggccc tgcatggaac gcatttttcc ttcctttttt ccccatcaca    600
 gagccacggg caagaagctg cggcggcaga gcctctgtca aagccagctg gacagaggga    660
 tggctacttg cattgttaag taggagcgct tcacagtgac catgggccag cctggaactg    720
 ccttctccca gggaaggggg gagcaggcgt gagtgggtgt gaagcacagg gaagcttctc    780
 tgcctggtga tcccaagagg gccttcaaca ggtgccctgc ctggctgaag gaggaaggtg    840
 cccgggaaat caaactcggt atttgccagg ttgtttgaag gttaatgtta tgggtaatca    900
 aagggaggag acaaaagaca gaaaaatgga aacccttcag aacagtgaaa ggtttcattt    960
 acctttggta                                                           970



      <210> 2084
      <211> 2239
      <212> DNA
      <213> Homo sapiens


      <400> 2084
 acgtgatacc gaaagactaa tgctatgtag gagctgacac agcacgggag gactatgacc     60
 acctaaggaa cagtgagctg tgtcaggaca gaaatgagca agcttgagtc tccgggcaca    120
 tctcaggaaa cagtaatgca aggcgcacgt cagggctgtg actcactcct cagagcaggc    180
 ttgggtcccc agtgtaagaa tgaacagaca gccctcccac atcatgtagt gtggatggtg    240
 gggctgcagg gcatgtcgtg ctcttgccgg tgggctgcca gagacatgtc agacccactt    300
 cttagtgagg gcccattcat ttcctctctg ggttgcattt catcataatc actcggtacc    360
 cacgattctt cctgacagcc tgaaacaagc aggctttgca tccttttcag gcctggggtc    420
 tggtcctacc ccaggggctt ctgttttcac ccacaacaga ttcgcctcca tgccagagac    480
 accaccataa agccacttct gctgccagag tccccagtct ccaatcacca agaaattctc    540
 caccaagggg caagctccag ccatctaact tgtaatcagt agcatcaaca ttgtcttcag    600
 atttgccgaa gagatcgggg tcgtgcctac acttgctggc tcggcaggct ttcaaatgca    660
 ggtatctctg agccatttgt gacaccagag catcactgga caagcctgtg ctggcccagg    720
 tactctgtgc acctggtaag gctgaacaca tccgcaagag cgtgggacct ggggaaatcg    780
 ccagttgttt gctgtcctgc cattgccgtt ctacacatcc ctggagacta tgagcatggg    840
 ttgtggtgcc gtagtggctg ggcagtatca gaaatgtcca tttttcacca ttcccagtgc    900
 caacttccca tggcagaaac aggaaggaat gtctggcaac ccaccaaggg tcagacgcca    960
 catcagcctg agcagaagct gcctgacact ggctgttcca atgacaatta gacgttcttg   1020
 ggaaggtgcg ccctttgtgg gagctcagga tgggtgtcgt cctcttcttc cagggcggcg   1080
 ggcgcttctc ctgcaccttg gcctggcgcc tcttctcggc ctcctccgcc tcccgtttct   1140
 cctccttggc caccttgtaa ggccacttgg gtatccgcag gtggccgctg cctttatgct   1200
 gcccttccgc gccggcccct cgccgcgccg ccggaatttc ctgcgccgcc aggatttcct   1260
 gcaccgccag ccgcctcttc ccccagcaca aggtgctctc ggggcacata gtcatgtggt   1320
 ccagggcgcc ccggtcctct gggccccgca tggagcgcgg cgtcagcgcg gacagctcgc   1380
 agtccctgag cctctgcagg cagttcttgg agccctcggg cttttgcggc ctctcgggga   1440
 gcggcggcag ctcaagctgg tactttttcc ccaacagctc ccggcagggg cgctccagga   1500
 gcctctgcat gaggcggacg tataagtggc cactcctctg gcgacatccc acggcggggg   1560
 ccctcgcgtg gacacccgcc cctgctagct cagggctccg atgcgatccg ttcgaccctg   1620
 catggcggct ttcaacccga acgcgtccct ccttcaagat caagaccccc tcgccgcacc   1680
 agcgtccgca gcagccccat gcctcctgga cgccctcctc cgggacgctc tccaagccct   1740
 cgacgccgtg ctcctcctcg tcctgtgcgc ctaggagtgg ggacggcggt ggcggggtca   1800
 tgcagggctc cccagccaac ctgcggccgg gtcccagcca gcagcaccat gccagcggcc   1860
 ggaggcgtgg gctgggggcc ggggcaaccg tcccggaaaa ccgggcgcgc cccaaggtcc   1920
 ctgcttctcg cttccgcgtc cccagagaag ccggtagctc ccgcccccag cccggcagaa   1980
 acctcctttc tttacattat taagtttgtt ttcattttaa ttttattagg acattgatag   2040
 aatcactttc ggatttttga gattaaaaat taaataattt tcatctttac cctttttaaa   2100
 tttttcacac tttattttaa tgattttatt cttttgtaaa ttttaatata ttgtaattta   2160
 tatcttcaat tattatggaa gaattttaga aaagtccttt cacataataa agactaatta   2220
 ataaaatata aaaaaaaaa                                                2239



      <210> 2085
      <211> 435
      <212> DNA
      <213> Homo sapiens


      <400> 2085
 cccgggtcga cccacgcgtc cgagctcctc gttgtggaga caagatcaaa aatcatatgt     60
 atagaatgtg actgtggctc ccttaaagat tgtgccagtg atagatgttg tgagacctct    120
 tgtacccttt ctcttggcag tgtttgcaat acaggacttt gctgccataa gtgtaaatat    180
 gctgcccctg gagtggtttg cagagacttg ggtggtatat gtgatctacc ggaatactgt    240
 gatgggaaaa aggaagagtg tccaaatgac atctacatcc aggatggaac cccatgttca    300
 gcagtatctg tttgtataag aggaaactgc agtgaccgtg atatgcagtg tcaagccctt    360
 tttggctacc aagtgaaaga cggttcccca gcgtgctatc gaaaattgaa taggattggt    420
 aaccgatttg gaacg                                                     435



      <210> 2086
      <211> 857
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> misc_feature
      <222> (1)...(857)
      <223> n = a,t,c or g


      <400> 2086
 tgacatcgcc ctttcctctt ggccatgccc gctggcgagc cgagcccccc caacgatgag     60
 gtcgtcctgt gtcctgctca ccgccctggt ggcgctggcc gcctattacg tctacatccc    120
 gctgcctggc tccgtgtccg acccctggaa gctgatgctg ctggacgcca ctttccgggg    180
 tgcacagaaa gtgagtaacc tgatccacta cctgggactg agncatcacc tgctggcact    240
 gaattttatc attgtttctt ttggcaaaaa aagcgcgtgg tcttctgccc aagtgaaggt    300
 gaccgacaca gactttgatg gtgtggaagt cagagtgttt gaaggccctc cgaagcccga    360
 agagccactg aaacgcagcg tcgtttatat ccacggagga ggctgggcct tggcaagtgc    420
 aaaaatcagg tattatgatg agctgtgtac agcaatggct gaggaattga atgctgtcat    480
 tgtttccatt gaatacaggc tagttccaaa ggtttatttt cctgagcaaa ttcatgatgt    540
 tgtacgggcc acaaagtatt tcctgaagcc agaagtctta cagaagtata tggttgatcc    600
 aggcagaatt tgcatttctg gtgacagtgc tggtggaaat ctggctgctg cccttggaca    660
 acagtttact caagatgcca gcctaaaaaa taagctcaaa ctacaagctt taatttatcc    720
 agttcttcaa gctttagatt ttaacacacc atcttatcag caaaatgtga acaccccaat    780
 cctgccccgc tatgtcatgg tgaagtattg ggtggactac ttcaaaggca actatgactt    840
 tgtgcaggca atgatcg                                                   857



      <210> 2087
      <211> 449
      <212> DNA
      <213> Homo sapiens


      <400> 2087
 agacactgct cagcaaccta gaagaagcca agaagaagaa agaggatgcc ctaaatgaga     60
 ccagggaatc atagacaaag ctgaaggagc tcccaggagt gtgcaatgag accatgatgg    120
 ccctctggga agagtgtaag ccctgcctga aacagacctg catgaagatc tacgcacgcg    180
 tctgcataag tggctcaggc ctggttggcc gccagcttga ggagttcctg aaccagagct    240
 cgcccttcta cttctggatg aatggagacc gcatcgactc cctgctggag aacgaccggc    300
 agcagacgca catgctggat gtcatgcagg accacttcag ccgcgcgttc agcatcatag    360
 acgagctttt tccaggacag gttcttcacc cgggagcccc aggataccta ccactacctg    420
 cccttcagcc tgccccaccg gaggcctca                                      449



      <210> 2088
      <211> 348
      <212> DNA
      <213> Homo sapiens


      <400> 2088
 ggcacgagga tacacgcacg cacttaaaag agagcatgtg gcatgttcat tgtggaacac     60
 aatatgaata cagggcatgc attttgcagc agggagactg tccacaaaaa ccttttgtac    120
 cggtcacggg agccctgtgg acatctgcac agccaagccg cgggacattc ccatgaatcc    180
 catgggcatt taccgctccc cggagaagaa ggcgactgag gatgagggct cagaacagaa    240
 gatcccggag gccaccaacc ggcgtgacgt ggaaccgacc aaggccaatt cccgctttgc    300
 taccactttc tatcagcacc tggcagattc caagaatgac aatgataa                 348



      <210> 2089
      <211> 348
      <212> DNA
      <213> Homo sapiens


      <400> 2089
 ggcacgagga tacacgcacg cacttaaaag agagcatgtg gcatgttcat tgtggaacac     60
 aatatgaata cagggcatgc attttgcagc agggagactg tccacaaaaa ccttttgtac    120
 cggtcacggg agccctgtgg acatctgcac agccaagccg cgggacattc ccatgaatcc    180
 catgggcatt taccgctccc cggagaagaa ggcgactgag gatgagggct cagaacagaa    240
 gatcccggag gccaccaacc ggcgtgacgt ggaaccgacc aaggccaatt cccgctttgc    300
 taccactttc tatcagcacc tggcagattc caagaatgac aatgataa                 348



      <210> 2090
      <211> 412
      <212> DNA
      <213> Homo sapiens


      <400> 2090
 ttgctcccag tgaagtcatt cttcatgtta tcttgcttgg cgagcacttc cttctggaaa     60
 cgcaggaaca tcctgtacct gtctgcgctg gtggctccgg ccaggtagga gctgacatag    120
 tggtgccggt ccctggtgcc tctggacccg gcctcctggt agcacagcac cttcaagtcg    180
 ggcagccgga gttcttccct cctgcgccat ccaggagggc cccgtccagg agggcctcct    240
 ttcttttctt ccttcccctc tctgacagcc tccactggaa ggaaatcctc ctctgaagtg    300
 tgggaaagag aggcctgggg gttcaggtac ctgaacagcg gggtgtcctg ggcctcactg    360
 gggaccacgg gccggggggt ggggaatggg gcccgggccc cttttccctc cg            412



      <210> 2091
      <211> 412
      <212> DNA
      <213> Homo sapiens


      <400> 2091
 ttgctcccag tgaagtcatt cttcatgtta tcttgcttgg cgagcacttc cttctggaaa     60
 cgcaggaaca tcctgtacct gtctgcgctg gtggctccgg ccaggtagga gctgacatag    120
 tggtgccggt ccctggtgcc tctggacccg gcctcctggt agcacagcac cttcaagtcg    180
 ggcagccgga gttcttccct cctgcgccat ccaggagggc cccgtccagg agggcctcct    240
 ttcttttctt ccttcccctc tctgacagcc tccactggaa ggaaatcctc ctctgaagtg    300
 tgggaaagag aggcctgggg gttcaggtac ctgaacagcg gggtgtcctg ggcctcactg    360
 gggaccacgg gccggggggt ggggaatggg gcccgggccc cttttccctc cg            412



      <210> 2092
      <211> 1231
      <212> DNA
      <213> Homo sapiens


      <400> 2092
 tttttttttt ttagcacttg gttattttat ttcctcaaaa ataaaacaga aaggaggcgg     60
 ggccccagct cagcaccagg tgggcagctc ggagttgtgg cctccctcct ccagggctcg    120
 cctccgcctt tcctcccgcc cctactggca gccaacaagt caacggaatt cctggccttt    180
 gagatgtcac cccaaatgcc acctgagttg agtgaagaaa cactctcttg gtgaaagcag    240
 aagcggagct accaggccag gcattgctgg tggccggcat cacctgagct cgcctgtgtc    300
 ctgcccagct tcagtgggtc ttcccccggc cctctgagat gacatcctcg ggccgggcgc    360
 gcatgtacca ctccacccag gagccatcgt agatgggcac gtctggcttg ccgcagaggt    420
 aggcccctag tgccacgtgg caggctgtga cgccagagcc acacgtggcc accagtggct    480
 tagacaggtc cactttcttc tcctggaaca gatggcggat ctcctcaggg ctcttctcca    540
 gcccctcctg gctcaggaag tctgtgaagg ggatgttcac ggtacctggg atgtggccag    600
 gttcaatgcc gtctcggggc tcgggctcgg tgccgcggaa cctgccagtg gctcgggagt    660
 ccaccacctg gaagcgccgg gattccaggt tctccttgat gtcctcgtag gtcttgatga    720
 aggcggggtc gagctgagcg cggaactcgg cgggagcagg ttggctcttg ccggagctga    780
 gcgggaggtt ctggcgcagc cagtggcgga ggccgccatc aagcagtgac acggcgtggt    840
 ggccgaaggc gcggaacatc caccagacgc gcggggcgga gtagaggccc tggtcgctgg    900
 cgtcgtagat cacgacgtgg gtggccgcgc ccacgcccag gcggcctgcg tactccgcga    960
 aatgctcggc cccgggcagc atgtggtcgt agggcgaggt gcggtcgctg cactggtcga   1020
 tgtcgaagaa agcggcgccc gggatgtggc gctcctcgaa ctcgcgtcgc gcgtcgcgcc   1080
 ccagcttcgg caggtaccag gaggcgtcca gcagctgcag aggctgccca gcgcgcgggg   1140
 cccgcagcgc ctccgccacc cattgcgccg acaccagcgc gcggcagagc tgcggcgaag   1200
 ccatggcggc gacactcggg ctgcgggcct g                                  1231



      <210> 2093
      <211> 3300
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> misc_feature
      <222> (1)...(3300)
      <223> n = a,t,c or g


      <400> 2093
 atggcgggcg cccttccccc agcctcgctg ccgccttgca gtttgatctc agactgctgt     60
 gctagcaatc agggagactc cgtgggccta ggatcctccg agccaggtgc gggatataat    120
 ctcgtggtgc accgtttttt aagcaggtca gaaaagcgca gtattcgggt gggagtgacc    180
 cgattttcta gggatttccg atttggaccc cccatcaaca agattttcgc ctgtggggca    240
 aaccagcgtg gacggcttgc tgcaattctc tcagggccag ccggtgaagg gcaatcagct    300
 gttgcccgtc tcactggtaa aaagaaaaac caccctggcg cccaatacgc aacccgcctc    360
 tccccgcgcg ttggccgatt cattaatgca gctggcacga caggtttccc gactggaaag    420
 cgggcagtga gcgcaacgca attaatgtcc aatactcacc ggttgaaaat atttggtaat    480
 gacccccagc tgccccgagg gggattcgtt attggcgcgc gtaggagtaa tggctcccgg    540
 aaacgccatt actttgctgg taatgaacgt gcccaggagc tgcttactga ggacgcactg    600
 gatgatctca tcctttcttt tctactgact ggtcaacaga caccggcgtt cggtcgaaga    660
 gtatctggtg tcatagaaat tgccgatggg agtcgccgtc gtaaagctgc tgcacttacc    720
 gaaagtgatt atcgtgttct ggttggcgag ctggatgatg agcagatggc tgcattatcc    780
 agattgggta acgattatcg cccaacaagt gcttatgaac gtggtcagcg ttatgcaagc    840
 ccattgcaga atgaatttgc tggaaatatt tctgcgctgg ctgatgcgga aaatatttca    900
 cgtaagatta ttacccgctg tatcaacacc gccaaattgc ctaaatcagt tgttgctctt    960
 ttttctcacc ccggtgaact atctgcccgg tcagacacct ccaacaggag cattcagctg   1020
 gcatcaggtt ggtgcccccc tcggatggag ctgccagagg aaggagcagt cttcaatctt   1080
 tgctcttttg cagcctttac tagtgatacc ttcagggatt ttgccgattt cggacccccc   1140
 atcacacagg attttcgcct gctggggcaa accagcgtgg accgcttgct gcaactctct   1200
 cagggccagg cggtgaaggg caatcagctg ttgcccgtct cactggtgaa aagaaaaacc   1260
 accctggcgc ccaatacgca aaccgcctct ccccgcgcgt tggccgattc attaatgcag   1320
 ctggcacgac aggtttcccg actggaaagc gggcaggatt ttgccgattt cggaaccacc   1380
 atcaaacagg attttcgcct gctggggcaa accagcgtgg accgcttgct gcaactctct   1440
 cagggccagg cggtgaaggg caatcagctg ttgcccgtct cactggtgaa aagaaaaacc   1500
 accctggcgc ccaatacgca aaccgcctct ccccgcgcgt tggccgattc attaatgcag   1560
 ctggcacgac aggtttcccg actggaaagc gggcaaaata aagacccaac tcaatggatt   1620
 gctacttttg gtgcaactat aacaccaccc gcagtgaaac gaaatgtgag gaaaattatt   1680
 cttcatgaga attaccatag agaaacaaat gaaaatgaca ccgctttggt tcagctctct   1740
 actggagttg agttttcaaa tatagtccag agagtttgcc tcccagactc atctataaag   1800
 ttgccaccta aaacaagtgt gttcgtcaca ggatttggat ccattgtaga tgatgcctcg   1860
 ctgccgcctt gcagtttgat ctcagactgc tgtgctagca atcagggaga ctccgtgggc   1920
 ctaggatcct ccgagccagg tgcgggatat aatctcgtgg tgcaccgttt tttaagcagg   1980
 tcagaaaagc gcagtattcg ggtgggagga cccgattttc taggggattt ttgttcccaa   2040
 atgggaacca acactcaacc ctatcttggg gctattcttt ttattaataa gggatttgcc   2100
 cgatttggga acccaccatc caacagggat ttttcgcttg ctggggcaaa accagcgtgg   2160
 acccgcttgc tgcacttctc tcagggccca gggggtgaag ggcaatcagc tgttgcccgt   2220
 ctcactggtg aaaagaaaaa ccaccctggc gctcaatacg caaaccgcct ctccccgcgc   2280
 gttggccgat tcattaatgc agctggcacg acaggtttcc tgactggaaa gcgggcagtg   2340
 agcgcaacgc aattaataat aaccaataca gagaagtgct taaaggagct gatgaagctg   2400
 aaaaccaagg ctcgagaact acgtgaagaa tgcagaagcc tcaggagccg atgcgatcaa   2460
 ctggaagaaa gggtgtcagc aatggaagat gaaatgaatg aaatgaagcg agaagggaag   2520
 tttagagaaa aaagaataaa aagaaacgag caaagcctcc aagaaatatg ggactatgtg   2580
 aaaagaccaa atctacgtct gattggtgta actgaaagtg atggggagaa tggaaccaag   2640
 ttggaaaaca ctctgcagga tattatccag gagaacttcc ccaacctagc aaggcagtcc   2700
 aacgttcaga tgtctaggat atttcgacat tcttctgtag gcggtcgatt tatcaaatct   2760
 catgttatca aattaagatt gggtaacgat tatcgcccac caagggctta tgcacgtggt   2820
 cagcgttatg caacccgatt gcagaatgaa tttgctgnaa atatttctgc gctggctgat   2880
 gcggaaaata tttcacgtaa gattattacc cgctgtatca accccgccaa attgcctaaa   2940
 tcagttgttg ctctnttttc tcaccccggt gaactatctg cccggtcagg tgatgcactt   3000
 caaaaagcct ttacagataa agaggaatta cttaagcagc aggcatctaa ccttcatgag   3060
 cagaaaaaag ctggggtgat atttgaagct gaagaagtta tcactctttt aacttctgtg   3120
 cttaaaacgt catctgcatc aagaactagt ttaagctcac cacatcagtt tgctcctgga   3180
 gcgacagtat tgtataaggg cgataaaatg gtgcttaacc tggacaggtc tcgtgttcca   3240
 actgagtgta tagagaaaat tgaggccatt cttaaggaac ttgaaaagcc agcaccctga   3300



      <210> 2094
      <211> 1116
      <212> DNA
      <213> Homo sapiens


      <400> 2094
 aatacatgtc ccctagcctt tgaccactgt cagccacctg tgtcccttga gccttcgggt     60
 cttcacttcc cacttggaca tcactgctgg acattcccat cgagatgaca cctgggttcc    120
 aatcccagct ctgcctttga agcacttgcg gccaccgtca agtccctttg ctctcggacc    180
 ctgggtttct catcctttaa tgaggtgggt tcagaagctc tcccatcttc acagcaaccc    240
 tggcactggc ttctcaatgg gagggaagca gcagagaaac tgaagtgtta gacactatgt    300
 gtcccaccac cccattacag agacatatga caatgttcag caggtcatct ttaatgcaga    360
 ggaggagatg ggatgtcact cgctgtctgg aggcacgtgg gtggtgtgcg ggccctcact    420
 ggccagcctc tgggtggccc cgcctatccc agtatgaacg tagccaactc aagccctcta    480
 ctgtgtctca gcccacgaag cctttgtagc cttcatcttc cagcagttga aacagatagg    540
 ggaaattcag ctctccgggg ctgctgggct cccctcgacc tgggacctgt gccacctgca    600
 catgcccaac aatgggcagg aactcccgga tgtttcctgt caggttccca tccatgatct    660
 gccagtggaa tatgtccatt tgtaattgga ggttgggtct tcctaccttc tgtaagatgg    720
 ctgccgcctg ctggggcgtg tccaggaagt actgggggtc agtgatgcgg gtgttgatgg    780
 gctccagcag tcccacgagg tcctcctgag ccaaaacccc agctgcatgc ctcaggttct    840
 ccagaaaaac ggcctccatc tcagccttga ctgctattcg atcagctccc tggggtactc    900
 ggccagccat caggtggatc atgtccagcc tcaggaacgc tgccaaatac accaggcctc    960
 ctcttgccac agcacccttg caaggaacac tcaacttcct gcccatcaag caatgcccac   1020
 tccgcacggc ctgctccagt ccctctcgga aggccgcatg tctcccgggg acggcaccca   1080
 gccccatttc ccccttctct tggtctcccg ggggcg                             1116



      <210> 2095
      <211> 2249
      <212> DNA
      <213> Homo sapiens


      <400> 2095
 tttcgtagga aagctgggac gggccgggac cacaggagcc ccagccccac acagcaacca     60
 cccgggcgag aaagaaagaa agagccaggg aggcgggcga agcgcgggga gagaagcaga    120
 gaagaaatat tcaccttccc gcctcatgcc cactttgagg cacttcttga ggcggcagta    180
 ttggcactgg ttgcggtggt gctggtcgat gggacagttc ctgttggcac ggcatgtcag    240
 gtagatgaaa ctcaagagaa aaggtgtgga taaatgaaac tagcccatga tgaacctgtt    300
 ttctccgtga ccacaatatt aaccaggatg aatggcggtg gcagtgggcc tgcatcacag    360
 gttgcagcag atgttctcaa tatttctatt aaaatttcct tatttccata tgcaagagga    420
 gccccagagc tgcatcctta tggtagctac catgccgtga tgtaagctgc cattcactgg    480
 ggagctttgg caatagaatt ggctagatca ggaagcctat gtcaactatg gaacaacaac    540
 ttgcagctca tctctattga tgatacactg cctctaggac tgggacagat agccactgag    600
 tacctgcttc aaatcaccct gcacgttttc tctttggaaa gataagcact ggagaaccat    660
 ctcgttacct tcagcagaaa tggaaacaaa tcaagacatt aagaatgccg cagtggacag    720
 cagttatgca aggttcagca gaggaagttt tcaagatggt gtgcctcact agccagaaat    780
 cagaaaagat cgaagctagc cttttcatct cagctgctcc ttaaatcagt gcaacccctc    840
 caaattaatg tgaattgaaa cttgcattgc ttttcaactt aattgaatac ttactatatg    900
 tgaaccactg cacaaaatat ggggaagaag atgtgggaga caaagatgtg gagcctgtct    960
 tcaataaatt tacagttagt ttcagggtac attgtttttc ttctgctgtt aattaggtgt   1020
 atccccaaga caataaatac atgaatggaa aagtatattc tgtgttttaa gtctctttaa   1080
 taaaaaacaa aacaaaatcc aaaaaaactc ctaacatggc aactcaggac attttaatcc   1140
 ttttttttgt tgttgggctt ctgataggat ccattttatt gattccataa atatttagta   1200
 gactttagac atattaatac attgtagttt gagttaattt gcattaaatt ctgttttttt   1260
 ccccttaggt atagattgtc tgttggaaaa atatattgct tgtggatttc ttggggagtg   1320
 ggaaggtgaa ttatacctgt tgtctctaca gtccactacc ttccacaccc tagggcagtg   1380
 gtccccaacc ttcttggcac cagggatcag tttcctggaa gacaattttt ctgtggatgg   1440
 tgtggggatg gttttgggat ggaactgttc cacctcagat catcaggcat tagttaggct   1500
 ctcataacga gtgcgcagcc tagatccctc acatgcacag ttcacagtag ggtttgcgct   1560
 gctatgagaa tctaaggctg ccactgatct gacaggaggc agaactcagg tggcaatgct   1620
 tactggccca ctgctcacct cttgctgtgc ggcctggttc ctaataggcc atggaccccc   1680
 acagacgggt actagtctgc agcctgtgga ccccagccct aggggcctgc cattctgagt   1740
 gagttattag catgaagaag aggaagatct ggatcaaacg tgggtgatgg tactcagaga   1800
 cccaagatag gatagggatg gaacaaaatc catctgggca acggctctat gaaaatttgg   1860
 ctaagtaatt atttcagtat tcattgtatt cattgtcctt cgtgttccat aagttaaatg   1920
 actgtctaat ttttccaaaa atttatttct gacttgagaa taagtgtgtc atgattttcc   1980
 cagtgtaaag acactgatat aactgtagat accagacatt ttatgtagtg tctatgacac   2040
 attttagtat gtatgagcca acaatagaca tgtctttgtc ttgaggagtg tccgatctga   2100
 attgaaaatg tgtcagcttt tttttaacat catcaacaga cttcttaatt aagctgccaa   2160
 tacatactgc caatacactg tgtgctgtct gagaaatgca ttgtgtaagt gctatttcca   2220
 tcttattaaa taaacgaatg ttgctctgt                                     2249



      <210> 2096
      <211> 1345
      <212> DNA
      <213> Homo sapiens


      <400> 2096
 tttttttttt ttccaatctt cattctcggg gttggcccgc cccgatagtc actccatgtc     60
 ctcgtttact ggttcatctt cgtaatctct gtcatggtca aaatctggac tgtggttggc    120
 tgttgtcact aaggacaggg gcccttcagc ttcctctgga tcgaggggct cttctttgac    180
 gtgtacagga tgcacggctt gcataggaga tctgcctgga ctgctgtcac tctcgttgct    240
 gttggtatgc tccattgccc cgttcagctc ttcccgtatt gcgctggcta agttgcccag    300
 agtgggattt cccatggaag cggtagtgta tagaggtata ctattctcag ccattgaagc    360
 ctgtaaagct gcattgagag gtgtgcagta ggcgtggctg ctctgcatgt ttttaataag    420
 ggaagggtta ccactgatct tttgtggcct tcgtttttgg aattctactt catccactgt    480
 ccatactgcc cctttaacgt tttctactcg cacaaaacac ttgtgaagac taagattatg    540
 acgcactgca ttcttccacg tggccgcgtt gcgtcggaag taagcaaaca ttcgtgtgaa    600
 ccagttatag atctcattta gtgttagctg cttttctgga gattcgagaa tggcctgcct    660
 aattaaagat gcatatgtaa atggtggtct aacttctgcg ttcttataaa attcttggtt    720
 ctgcgcaata tctgctgacg aaatgggcac gttgtatttg tctgagtacc gcctgcggat    780
 gggtcccccc gtgtgcatgc tggtggttgt gatgacagag gggccttggg tgacgggagt    840
 caggggggcg gttggggtcg ttggagtatg aggtaagctc tgtggagaag cctccgatgc    900
 ggacttggag agagtgacac ttgataccag attcaagggc tgaggggcgg ctttgggttc    960
 tgtagacttc acatgcaggt gggtcatcat ggcttgcagg cgttctttgt cttttgcaag   1020
 ctgtagctct aactgctgta caacctgcat ttgtactcta cattgggctg tacttctatc   1080
 gtccagcgca tgctcactgt tgagatgttt tagaaatgat tggaaatctt cgcacactgc   1140
 ttcacagcct ggccacttgc atacaccatg tccatagaga ggatggctat gggagtgctc   1200
 ctcatgggac aaactttccc ttttgggagt gtggactgag agctgtccat tggtagaggc   1260
 atgtgggttc attattaagg aggtcttgga aggtgcagag gaggagacac atgtcgtggt   1320
 cagatccaaa ctgctgtgat tgttg                                         1345



      <210> 2097
      <211> 374
      <212> DNA
      <213> Homo sapiens


      <400> 2097
 tttcgtttcc tggagaagac cctgaggacg aactctgact tctggtgggc ctccaatatg     60
 cagggcacga tgaggtacgt ccctggttcc agacacagct cctgactcac ttctttctcc    120
 ttgagaaacc tatcaggctg gctcagagga gtgtttctct ggaagaactc agggggcagt    180
 ctcctctggt catcatggta cctatagagg tagaagccaa tggcgaggag aggcttccgc    240
 ttgcggcacc tgtgcctggg cttctggagc agggacacca gcacgctgca gggcctcagg    300
 gatctcctgc cctcctcggg cctccagaca gacagcagga actgcgggtt cttccaaaat    360
 gtgtcctgca gcag                                                      374



      <210> 2098
      <211> 472
      <212> DNA
      <213> Homo sapiens


      <400> 2098
 aaaaattgca gctgccttct ccccaagata gttttcagtt ccagacaaaa ccatccagaa     60
 ctcaggaggc cttctcaagt gaatgctgca gaacagagga agagttccta gatcaagtga    120
 agaggaagct ggctcagacc agccctgaga aagacctgtt gaccacaaag ccttgtcact    180
 gtaaggatat cctgaagtta gtgctcttac ccctcaccca gcattgcttg gtcgttggag    240
 aaaccacctg tgcattttat tacctgctgg aggctgcggc tgcctgcttg gacctgtcaa    300
 ataattatat ggtctgtttc aacatgggac gtattacttt agccaaaaaa ttggctagga    360
 aagcccttct actgctgaaa aggaattttc cttggacctg ggttgggggc cttttccaga    420
 cattccttgg aaaggaatgg gctttcatgt accctgagcc acctccaaac ga            472



      <210> 2099
      <211> 663
      <212> DNA
      <213> Homo sapiens


      <400> 2099
 cggacgcgtg ggcaggggcc gagagggagc tgtgcttggg gcggggccga gacggagcga     60
 ggggtgcagg gtgtgagaaa cggggagggg tttgaggagg ggattggagt gtggctcaag    120
 ttcgggaggc gttacctgcg gagggtttga ggcaggccca ggagcgagcc cacggtctgc    180
 cgacgcgggg ccagcggcgg gccccaggat ccggagcttc gggcggggcc gagtccagct    240
 ctctgcccgc aggagacaag gaaaaccaat gggaacagta acaaacagaa ccgcaagagc    300
 tcctgtgaca atgctgagcc tgatcactgc gccttgcaga gcagatgccc tctgcacctc    360
 cgctcctgtt aagaaaccag agggttttta attgtctgtt cccatctagc cgctagtgag    420
 tattaattat ggaaatgaag tgtacattta acccaagaaa atgctcactc tagagaaatc    480
 tcatagggga agtcgttgaa agccgattta ctaaatgacc tcttcgccaa atgacccatt    540
 tgcctaatga ccactttgcc aaatgatcag tttgctgaaa gccaattcgc tgaaaatctg    600
 tttgtgggat gtcctgctta tcagtaactg acagtcagac gcagattatc ccaggctccc    660
 agg                                                                  663



      <210> 2100
      <211> 3041
      <212> DNA
      <213> Homo sapiens


      <400> 2100
 tttttttttt ttaacctgaa agtatcactg tttatttcac atttaaaaaa atcatccggc     60
 agaaactagg tacgctgtga aaatagaata gtccactggt agagtttcaa ttgtgcaaac    120
 agacgtttgg tcccatcatt tttcttctct gaacatttct tcatctgcaa atgggggagt    180
 gccctgtgca ggtgacaaca gggtggtgaa gggccaccct taaacctgct gcagccctta    240
 cctttcacat ctgaacaggc agactcaaac ttcattgggg tggcccacaa agacttggga    300
 agctcaaaat ttggaaacat caaaattaaa cacagaccca atttctttgc atttttagtc    360
 ctgtattcta tgtttgacaa aatcactgta aaataaagca gcagtaagaa aagaagcaga    420
 ttcagaggac taaaagcagg aacagatggg aaaaaaaggc tggaaatcca ttcgtttatt    480
 tactgagcct ggtccaatgt caacagaact aggattaact aggttaagag ttggcaaagg    540
 acaggaaagc aaagtaataa aatttaaaag ctgaattggt acagtgttat gaagaagtgt    600
 ttatttagta tttatagtac cagattacag tcacttgttg atttagatat gaattttcat    660
 atgttagaag actcagggaa atacacagga tcccaaggag tgagactgag attctgggtc    720
 ttattagctg tactttgggt aatttactta accctctctc agcttcagtt tcctcaaatc    780
 taaattaggg cttaactaat cattatgtcc tttgtaagac tggaaatgtg gattagcagt    840
 tagacagtat gtatgtaccc agttttgtag atatgctggg acatagtagg tgttcaataa    900
 attatacata tacctgaata aacaaactat acataaatat tttataaatt atacatataa    960
 tcgaacatca tttaggtaaa ctctttaatg aaagacattt attgtcagat tataaaatca   1020
 gtgttgatga taagccctcc tacccacaaa acaaaaatcg tatgtatgaa attccctttc   1080
 ccgtaagtta tgtgcctgtc agccatccca cttcagtcca tctttggatg ctgaggctct   1140
 ggttgccagt ccttatctct acacctgtcc ctggtctaga ggagaaacga aggtgctctg   1200
 aggcccctgt aacagagacc cttgtcatcc atatttgcaa taaagacatc atggaggctg   1260
 tgcaaaagta tccttctccc caacttctgc aggcaccatt tccatctcac tacccagagg   1320
 tacatcagag agcaggagcc aggcaggtga caaagatgtg gaaggcttct aagtggttgg   1380
 ctttgccgtc tcagaagtgc gaagaaatga aaatccatca aaacagaatg ccattccatg   1440
 tttcaggctt ttacctcacc tcaaatcaaa tgtctgttct ttatttattg gtcccataag   1500
 tagacacgca cttggacttc tggttttaga acattctatt gttatccttt ctccttttaa   1560
 taaacacaca ctagtttcga ggaatctccc taataatcct ggcctgacat gctgcagaac   1620
 ttcaatttca taattttact aacaacagag gaatttcatc ttattattac caactaccac   1680
 attaaaggat ctgaaacagt aattcatgca taattctatt taataatggt tttcaaagta   1740
 ctttgctgtt tgaaaatgct tcccagatga ttctgatcgg agagttggga accactgccc   1800
 tagactgtaa ccactcaatt gaactttact cagtgctgct tccctgccca cttcaagtaa   1860
 acaatgctta actttttcgt ttctaaaaca actgagatta ctttctcccc cttagtttct   1920
 acaatgattg ttgaaaattt gtgggaaaag tttatcctta caaatgaaaa catgaaatct   1980
 gaagtggata aactaacttt taagaaatac atatccttac tcagtaagct gaggcaggag   2040
 gaccacttga gcccaggagt gcgaggcttc aatgagctat gattgcacca ctgcactcca   2100
 gcctgggcaa cagagcaaaa ctcctgtctc tagaaaaaat aaatacctat ctttcaaaac   2160
 ttgcataaaa agcccttgtc ttcacttgta cagcctcttc tgtttcatga atgagcatgc   2220
 tgaagggcta tttactctcc tatgaaaaaa tgttgttaca gtaaatgaca agtgttatga   2280
 acacaatgaa cctggtgtgt tagatgttaa gtgtgctgcc accccatgtg aacctcaaag   2340
 tgaaactgct cacataactg tttttttgct gcatgcaaac ctgctaatac aaagcgggct   2400
 cctgacttaa ggacagccaa tccctactct agacaatgac ccaaccagac ctagtataaa   2460
 aaggtagtct ggcccagtta aattcccttg gcaattggag actagcagca ggagctgaag   2520
 gtcatcatgt agaaaagaac ctcaaaggtg caagttaaag ttattacaaa ggaacagaaa   2580
 ctgtaagtat gcaaaagctg tgtagagaag ttggtgaata gagagaatgg agttaacaat   2640
 gcaaaaagaa gcaagtcaca tgcatgcaga gcccaagcct aaacatccac cttcccctgc   2700
 tgaggagcac cacccaattt ctactcttcc tgaggctggg aggtgatttc tgagtgggag   2760
 atggggttgg tgaggtggtt cctgaattcc ccggcacata tccttgaaat aatgtcacat   2820
 tgcttgagct aacttgtagc ttttgagtct ttttatgttt gtcccacttg agattccttg   2880
 caactaaaag agcataactg aaacaactag ttaagccaat accatttgtt aaaaataatg   2940
 caccattcta aatttctgtt tccctaacca aatctggcaa agtctgatcc attaagtttt   3000
 aaaacttttc taagtttaat gttgtcactg tatgtttacg t                       3041



      <210> 2101
      <211> 3041
      <212> DNA
      <213> Homo sapiens


      <400> 2101
 tttttttttt ttaacctgaa agtatcactg tttatttcac atttaaaaaa atcatccggc     60
 agaaactagg tacgctgtga aaatagaata gtccactggt agagtttcaa ttgtgcaaac    120
 agacgtttgg tcccatcatt tttcttctct gaacatttct tcatctgcaa atgggggagt    180
 gccctgtgca ggtgacaaca gggtggtgaa gggccaccct taaacctgct gcagccctta    240
 cctttcacat ctgaacaggc agactcaaac ttcattgggg tggcccacaa agacttggga    300
 agctcaaaat ttggaaacat caaaattaaa cacagaccca atttctttgc atttttagtc    360
 ctgtattcta tgtttgacaa aatcactgta aaataaagca gcagtaagaa aagaagcaga    420
 ttcagaggac taaaagcagg aacagatggg aaaaaaaggc tggaaatcca ttcgtttatt    480
 tactgagcct ggtccaatgt caacagaact aggattaact aggttaagag ttggcaaagg    540
 acaggaaagc aaagtaataa aatttaaaag ctgaattggt acagtgttat gaagaagtgt    600
 ttatttagta tttatagtac cagattacag tcacttgttg atttagatat gaattttcat    660
 atgttagaag actcagggaa atacacagga tcccaaggag tgagactgag attctgggtc    720
 ttattagctg tactttgggt aatttactta accctctctc agcttcagtt tcctcaaatc    780
 taaattaggg cttaactaat cattatgtcc tttgtaagac tggaaatgtg gattagcagt    840
 tagacagtat gtatgtaccc agttttgtag atatgctggg acatagtagg tgttcaataa    900
 attatacata tacctgaata aacaaactat acataaatat tttataaatt atacatataa    960
 tcgaacatca tttaggtaaa ctctttaatg aaagacattt attgtcagat tataaaatca   1020
 gtgttgatga taagccctcc tacccacaaa acaaaaatcg tatgtatgaa attccctttc   1080
 ccgtaagtta tgtgcctgtc agccatccca cttcagtcca tctttggatg ctgaggctct   1140
 ggttgccagt ccttatctct acacctgtcc ctggtctaga ggagaaacga aggtgctctg   1200
 aggcccctgt aacagagacc cttgtcatcc atatttgcaa taaagacatc atggaggctg   1260
 tgcaaaagta tccttctccc caacttctgc aggcaccatt tccatctcac tacccagagg   1320
 tacatcagag agcaggagcc aggcaggtga caaagatgtg gaaggcttct aagtggttgg   1380
 ctttgccgtc tcagaagtgc gaagaaatga aaatccatca aaacagaatg ccattccatg   1440
 tttcaggctt ttacctcacc tcaaatcaaa tgtctgttct ttatttattg gtcccataag   1500
 tagacacgca cttggacttc tggttttaga acattctatt gttatccttt ctccttttaa   1560
 taaacacaca ctagtttcga ggaatctccc taataatcct ggcctgacat gctgcagaac   1620
 ttcaatttca taattttact aacaacagag gaatttcatc ttattattac caactaccac   1680
 attaaaggat ctgaaacagt aattcatgca taattctatt taataatggt tttcaaagta   1740
 ctttgctgtt tgaaaatgct tcccagatga ttctgatcgg agagttggga accactgccc   1800
 tagactgtaa ccactcaatt gaactttact cagtgctgct tccctgccca cttcaagtaa   1860
 acaatgctta actttttcgt ttctaaaaca actgagatta ctttctcccc cttagtttct   1920
 acaatgattg ttgaaaattt gtgggaaaag tttatcctta caaatgaaaa catgaaatct   1980
 gaagtggata aactaacttt taagaaatac atatccttac tcagtaagct gaggcaggag   2040
 gaccacttga gcccaggagt gcgaggcttc aatgagctat gattgcacca ctgcactcca   2100
 gcctgggcaa cagagcaaaa ctcctgtctc tagaaaaaat aaatacctat ctttcaaaac   2160
 ttgcataaaa agcccttgtc ttcacttgta cagcctcttc tgtttcatga atgagcatgc   2220
 tgaagggcta tttactctcc tatgaaaaaa tgttgttaca gtaaatgaca agtgttatga   2280
 acacaatgaa cctggtgtgt tagatgttaa gtgtgctgcc accccatgtg aacctcaaag   2340
 tgaaactgct cacataactg tttttttgct gcatgcaaac ctgctaatac aaagcgggct   2400
 cctgacttaa ggacagccaa tccctactct agacaatgac ccaaccagac ctagtataaa   2460
 aaggtagtct ggcccagtta aattcccttg gcaattggag actagcagca ggagctgaag   2520
 gtcatcatgt agaaaagaac ctcaaaggtg caagttaaag ttattacaaa ggaacagaaa   2580
 ctgtaagtat gcaaaagctg tgtagagaag ttggtgaata gagagaatgg agttaacaat   2640
 gcaaaaagaa gcaagtcaca tgcatgcaga gcccaagcct aaacatccac cttcccctgc   2700
 tgaggagcac cacccaattt ctactcttcc tgaggctggg aggtgatttc tgagtgggag   2760
 atggggttgg tgaggtggtt cctgaattcc ccggcacata tccttgaaat aatgtcacat   2820
 tgcttgagct aacttgtagc ttttgagtct ttttatgttt gtcccacttg agattccttg   2880
 caactaaaag agcataactg aaacaactag ttaagccaat accatttgtt aaaaataatg   2940
 caccattcta aatttctgtt tccctaacca aatctggcaa agtctgatcc attaagtttt   3000
 aaaacttttc taagtttaat gttgtcactg tatgtttacg t                       3041



      <210> 2102
      <211> 2150
      <212> DNA
      <213> Homo sapiens


      <400> 2102
 agaggcgccg tcttcccggg tcccgagcac tctgtgccgg aggaatcagt gacattcgaa     60
 gacgttgccg tggttttcac agatgaagag tggagtcgtc tggtccccat acagagggac    120
 ctctacaagg aggtgatgct ggagaactat aacagcattg tgtcattggg ccttccagtt    180
 cctcaacctg atgtgatttt ccaattgaag agaggggaca agccgtggat ggtagatctt    240
 catgggtctg aggagagaga atggccagag agtgtctctc tagactggga aactaagcct    300
 gagattcacg atgcttcaga caaaaaatca gaaggatcat tgagggaatg ccttggaagg    360
 caaagtcctc tgtgtcctaa atttgaagtt catacaccca atggcaggat gggaacagaa    420
 aagcaaagcc cttcagggga gactcgtaag aaatccctct cccgggacaa aggcttgcgg    480
 cgacggtcag ccctgtccag ggaaattctc actaaagaga gacaccagga atgcagtgac    540
 tgtgggaaga ccttttttga ccactcatcc ctcacccgcc atcagaggac tcacactggg    600
 gagaagccct acgactgccg cgagtgtggg aaagccttca gccacaggag cagcctcagc    660
 agacatctga tgtcacacac tggggagagc ccctacgagt gcagtgtgtg ctcaaaagcc    720
 ttctttgacc gttcgtccct aactgtccat cagcgaattc acactggaga gaaacccttt    780
 cagtgcaacg agtgtggaaa agcctttttt gaccgttcat cccttactcg acaccagaga    840
 attcacactg gagaaagtcc ttatgaatgt catcagtgtg ggaaagcctt tagccagaaa    900
 agtattctta ctcgccatca gctaatccac actggcagga agccttatga gtgtaacgag    960
 tgcgggaaag ctttctatgg tgtctcgtct ctgaatagac atcagaaagc tcatgctggg   1020
 gaccctcgct atcagtgtaa cgagtgtggc aaagctttct ttgaccgctc atcccttaca   1080
 cagcatcaga agatccacac tggagacaag ccatatgaat gcagcgaatg cgggaaagcc   1140
 tttagccagc ggtgccggct cacgcggcat cagcgtgtcc acacgggaga gaagcccttt   1200
 gaatgcactg tgtgtgggaa agttttcagt tcaaaatctt ctgttattca acatcaacgg   1260
 cgttacgcca aacagggaat agactgagtt gggcaaaagc ttgggtagga caagaacttc   1320
 catacaaatt tgagatagat ctcgcctgtc ttaaagctgc catttgctca ttctacccac   1380
 tctggctgcc gttgtcctgt cctgcttctg cgccagagtg tttaataagc actcccttcc   1440
 tgctgtgtta cagaactgta ggggaggcca tggaaatgac tctaaagata caaaattttg   1500
 aagaggtttg tcagacaata ggatagatgt taggaggaga cacacctctt gtctgagaac   1560
 ctaggcccca ggtatcactg cactttaaga aactggaggc tgcaacagga gggaaaggca   1620
 gaatgatatc acagcagtac tatttttttt tttcaaaaca tttgttttga tggctgttag   1680
 tccccctctc ttggagcatt ttggggcact aatcttgttc tcttgtgtcc cagcttttag   1740
 acctcttact tccactgcta gtagctagca cttactgagc acctgcaatg aggtaaagac   1800
 tcagctaagg gttttacagg aagtagatta attgatcctg tcaccaacca tatgaagtag   1860
 gcactgttac catctgcatc tccagatgag caccctgagg tttagagaga ttaaatcact   1920
 tgcccaaggg tgaaccagct ggtaaaaggt gatgccaggt cttgaagaca ggtccacctt   1980
 caaaatctat tctctttacc attatgctcg atggtttgtt tgttttataa tttatgtata   2040
 tgtattatcc tctcaactag attgtaagca cttggaggtg tgacttacag gtctttgtat   2100
 ctcacacagt gccttgctaa taggtgctca ataaatattt atatgagtga              2150



      <210> 2103
      <211> 1017
      <212> DNA
      <213> Homo sapiens


      <400> 2103
 aaagtggaac ggatagtgaa agccaatgac cgtgaatata atgaaaagtt ccagtatgcg     60
 catagctgta ctgcccacat gatgcagatc ctcacctatg gggctgatga ccagatgcac    120
 caactaaaga gtacagatga tgacaagcag tgtgacacgt tggaattagt catggaaagc    180
 accagtaact tgcatttgtt atgggtttct ggttcagcgt tcgtagaaga gcactgtcgt    240
 ctttccattg cccctatcct ggaaagctgt ggactctgca ccaggcaaca gtcagctgat    300
 actgaggaac taccaggggt tcttcctggt atcagtgaga aagtggcagc aggcttgaaa    360
 tgcagactgg aagagagagc aagggcagat tactctgaaa gcagaagaga taactgcttt    420
 gcaatgaatt ggggcagcac agtggtgaag agggtgggct ctggagcaga atgtctattg    480
 ctagatccaa atcctggctc ttacaatcac cacttacaag ctgtgtcaac tcgtgataat    540
 cgtatccaca catcgaaata taatattctc accttcttgc caattaattt atttgaacag    600
 ttccaaagag tggcaaatgc ctattttctt tgccttctga ttttacagct aattccagaa    660
 atttcctcct tgacctggtt taccaccatt gtgcctttgg tcctggtgat aactatgaca    720
 gctgtcaaag atgccacaga tgactattta atgcttgaat gtgctttcac cttttgtgat    780
 gttatgtgcc agttcattaa ctggacacct tcaccagtca gggtcttggc aaaacacaga    840
 ggttatcctg aaattgggtg gattggagag tttaataatg atgggatcat tcacaaaggg    900
 tgtgggcaag gaaaagcagc tatggcagca acatggttgg caatactact agacctgaag    960
 aggcaaagga atgaaggagt gaccagacct ggagacgtag ttgaggcctg tttgtag      1017



      <210> 2104
      <211> 2945
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> misc_feature
      <222> (1)...(2945)
      <223> n = a,t,c or g


      <400> 2104
 gacatcatta acggattttt tttttttaac agcaaaaatg gaagataatt aaatgcagca     60
 cagtagttgt aaaacagatt tcattgtgtt atacatcact tcataaagta agcatagttc    120
 ccagttcttg cacattatgc tttttgcagc attgtaccac agaataatga ctccctaata    180
 actcagctga aaaatattta gatctacttg ctctaagaat aaggtcaaca ttaaacattc    240
 tcaggatgaa aagcttgctg gatgaaatag tgcaccatca ggaataaagg catgcaatat    300
 atttacagtc agatgaaaca agtgtgtcca taaatcaacc aaaagaccat ctcctccttt    360
 agggaaatac atggtattgc ttagcccagt accaataagt taacgtcgtg tgaaataatt    420
 ttgggtaatt ctggccctcc ttgaatctca tacagcccaa accaacccag aaggcttacc    480
 ccgctgggtt gatggtggct tatccatttg gcatctggga aacttctctt attttgctgg    540
 gatatgggct gtctagtggg tgggcttact ggacttggcc taagaaaaaa taagtccatc    600
 attcagatta atctgggagg ctaattctaa aatcggattt tatgagaatt gctagatttg    660
 gggctaggtt aacctcattt ccaaaagaaa aactcttact ggagagaaac catcatgtgg    720
 gctcattcta ttgtgtttat atatttcaca gtaaaatgat tcagtcttgc caggttccat    780
 attaggagga ttagaactac atcactcaat attttctttt gtctggtcta aaaatattat    840
 caagttaaat tatggactta tggatttttt ccattccagg acttcatttg cggggagcct    900
 tcagaaaaaa caggtcactt gcagtaatat agaaggacta aactgtgatt ctggaagacc    960
 cgggtttccc ctttcctgtc ccacccagtg agtcctttgt gtgtctgtta acagtgattt   1020
 ctggctcagt gaaatgtgat aatgacttca tatttgtgaa gagctaagta tcctgatatt   1080
 ttgatctttt caagcagata atttcaggca gaaatgatat agcttgtctt ttgttaggtc   1140
 tcactagggg aaaaaaaaat cgctcacaag agccttgcct acctcaacaa gaagtgtctc   1200
 tacttataca aatggcatgg tttccttttc tggttactgg gtccacaggt ggcctcgccc   1260
 atttgacttt gagtttgcaa ataaagtaca tccttgggtt tccttatctt taaacaagta   1320
 aagataaatt aggttaaagt gggaagaagg ttcacaggat gagaacatca atttcagctc   1380
 acagcaggta tgggtctaaa gtgcctcttt gcaggaaaga aagccaccac cagcagtcca   1440
 cctgctctca ggggaaggga ccaggcattg gaaaggctgc ctcgggagaa gtgactcaac   1500
 aaaatcataa gccggatgta gctttgtttc ctctttctaa tacgggcata tttattgcca   1560
 tctcaattga agccgtgctt caattaatgg aagaaaatgc acatgaaagt tctgccagaa   1620
 actaaaatgg ctcattgtag gcaggatgtg ttattaatat ttaatatcta tccaaccctg   1680
 ttctggcagg gctgttctct cctcagtact taccagagag ggagtagagc taatgcacag   1740
 ccatactcct ccccttttca tgaaatagtt tcatctttac ctagaggtca cgctacagat   1800
 gaagagtaaa atgaaagact gaatatgatc aatactaatt aaaatggggg ggaggtattg   1860
 aaaagagtcc taaaatgggc ctacaaataa tggagataca ttggactctt ccgtcattaa   1920
 caagatttag aataggctgg gaaatttcct gtttggaact gtgaactgtg acgggtgtgg   1980
 tccaacagaa aaaacactgg agagtcatgg ataccgaaat acaatctgag aagttacgga   2040
 aagcacacaa tgccctaggg caagcttgtc caacctgtgg cccgcatgaa gtccaacaca   2100
 aatttttaaa ctttcttaaa acagtctgag attttttttt ttttttttgc aattttctat   2160
 ttttattttt ttaagctcat caactatggt tagtgttagt gtgttttaca tgtggcccaa   2220
 gaaaattctt ccaatgcggt ccagggaagc taaaatattg gacaccccct gcctagggga   2280
 acattgtttc gtctacttgg ttagttcgtc ctaattgcat tttacctgca gtccaaaggt   2340
 tattttagga tgataggaac tgcaaggaac cccaaaccca aaggaaagga atcgttgaag   2400
 tgggttgggg gagagggagg gtcatttctg aggatacatt tcnggggggg gaaatacaag   2460
 tttgaggagg agggagctgg ggaggttacc tgtggttgcc aagtgttttt cctttgatgg   2520
 ggaaggagta agttggcaaa gggaccagga atctgtgtgt acatttcctg gctcctgttt   2580
 cccttaacca ccatcccttc aggggcattc tctgggcacc tttggggtcg ggtaagatgc   2640
 tctctactgc cctccgtttt agctgccttt atctcgtcta tatggcactt ttctgcgtga   2700
 aaagacattt gccttacagg gatgaaactg gacttgcaag agtttgctgt agaaggtgtt   2760
 caagtcaagg aagatgctca gaaatgacca ctgagagggt ggcatcagtg ctgacttaaa   2820
 aaaaaaaaaa aatctgacct cacatgttca tttttccaaa agtagagagg ctcagtttct   2880
 agcctctcaa accataagga agtaatcaaa atgagagtag atggaaatca tctcttacct   2940
 taagg                                                               2945



      <210> 2105
      <211> 1736
      <212> DNA
      <213> Homo sapiens


      <400> 2105
 tttttttttt ttaaaagtaa ttacaaatta agaatttatt tataagtttt catcttttta     60
 gaaataaaaa ggcttaaaaa acaaaatggt tgcaaaaatg gttaagtagt tttgttatat    120
 cctaattgct taggtgtgct ctgtaaattc caaataagta aaataatata aaaatacatt    180
 ttcatatctt tatagaacaa aaacaaaaca ttaaatgctt ttggattttc tttactcctc    240
 ccacagatga gttcacaaat acaaaaactg gtgtacattt atactcaagt acaaatctcc    300
 aacagccaag taattatagt ttgttctgtt atgtgcaaag tagattattt catatttact    360
 tggtatggaa agcagagtac aggctcaatg gacaataatc attaaacaca gattatgttt    420
 aagaaaatgc tgttgtaaaa atgtacaata gtacatacaa ttttggtaat tatgcacttc    480
 ttttaaagta aatacagctt ttagatataa atctttcaaa ggttttcttt gaagagctgt    540
 gaggtgacta tttcagattt gatgaacagt aatttgtcag taaacttctc aaaaaaccaa    600
 tccaagaaag aattgttttc tttttccctc catgtggtcg gtttcattct taaggaaggt    660
 ctgatgcagt aagaagatgc atttcacaaa cctttacaca agtttgtgaa ctgtcaacta    720
 aagacaccac ctctgatgtg gatggtttca ttcaatccat gttcgaccag ctttatatct    780
 tctagatcgt ctttaatgat gctaatcaaa tggctaaggc cttcctgttg ttgtttcaaa    840
 tgctgcttga tttctcgtaa cagatctgca tctatgtaat acctttcttc agatctgact    900
 gctccaaaat gattctgcat cctgatttga gacatcaatt catttagtcg gcccttgaac    960
 tgagtaggtg catttagttc accctgaatc gtatccagct gaactcgcaa ctgctcttca   1020
 tcagcctgaa tggcataacc actcttcctt tgaatttcct gtttgattag gacctgtaaa   1080
 gttctatggg aaagatccat gagtttcctc ttgtattgtg caattttggc tacagatgta   1140
 gtttgattct tttgtagctc actaatatct tcagatatga tatctaatct ggtttgatgc   1200
 tgcttagtca tctgatcttg aaccttcagt cttcggagaa gttccttaaa acccaccatt   1260
 ggtacaggaa ttaacctgaa gaaacgcagt gaacaatttt cagaccttaa gcctattact   1320
 acaaaataca agaagtgaag gttttagtaa cactcatgta attttacatc aactttctag   1380
 ggctataagg cagatctatg actatgagat aaccatgtta taccaaagag attttattca   1440
 acctccctat tttacaaatg aggaaataca gttcagtcaa aacattacat tattaaatga   1500
 aaacgcaaat agaattttcc gctcctagtt agttctcact atgctatgct gccttaccat   1560
 aatctttttt ttttcttatt tttttctttt tgttttggct gaagctttag ctggacaata   1620
 atcaatattt tttaaaggcc aggaaaatga aaataaactt gcctcatatg taagaattat   1680
 aattaatagc tcccatgttt gctttcctag tagcaaatat tagttcttaa atgaaa       1736



      <210> 2106
      <211> 418
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> misc_feature
      <222> (1)...(418)
      <223> n = a,t,c or g


      <400> 2106
 cccacgcgtc cgaaagaaag ttaagcaact acaggaaatg gctttgggag ttccaatatc     60
 agtctatctt ttattcaacg caatgacagc actgaccgaa gaggcagccg tgactgtaac    120
 acctccaatc acagcccagc aaggtaactg gacagttaac aaaacagaag ctgacaacat    180
 agaaggaccc atagccttga agttctcaca cctttgcctg gaagatcata acagttactg    240
 catcaacggt gcttgtgcat tccaccatga gctagagaaa gccatctgca ggtgttttac    300
 tggttatact ggagaaaggt gtctaaaatt gaaatcgcct tacaatgtct gttctggaga    360
 aagacgacca ctgtgaggcc tttgtgaaga attttcatca aggcatctgt agagatcn      418



      <210> 2107
      <211> 2143
      <212> DNA
      <213> Homo sapiens


      <400> 2107
 cgcagcgtcc cgccagccag ctccttgcac ccttcgcggc cgaggcgctc cctggtgctc     60
 cccgcgcagc catggctcag cacttctccc tggccgcctg cgacgtggtc ggattcgacc    120
 tggaccacac tctgtgtcgc tacaacctgc ccgagagcgc cccgctcatt tataatagct    180
 ttgcccagtt cctagttaag gagaaagggt acgataagga attgctcaat gtgaccccag    240
 aggattggga tttctgttgc aaaggtttgg cattggatct agaagatggg aacttcctta    300
 aacttgcaaa taatggcact gttctcaggg caagccatgg caccaagatg atgactccag    360
 aggtgctggc agaggcatat ggcaagaaag agtggaagca cttcttgtcg gacactggaa    420
 tggcttgccg ctcaggaaag tattactttt acgacaacta ctttgacctg ccaggagctc    480
 ttctgtgtgc cagggtggtg gactatttaa caaaactgaa caatggtcaa aaaacatttg    540
 atttttggaa ggatatagtt gctgctatac aacacaatta taaaatgtca gcttttaagg    600
 aaaactgtgg aatatatttt ccagaaataa aaagagatcc aggcagatat ttacatagtt    660
 gtcctgaatc tgtgaaaaaa tggcttcgac agctaaagaa tgctgggaaa attcttctgt    720
 taattaccag ttctcacagt gattactgta gacttctctg cgccatatat tcttgggaat    780
 gattttacag acctttttga cattgtgatt acaaatgcat tgaagcctgg tttcttctcc    840
 cacttaccaa gtcagagacc tttccggaca ctcgagaatg atgaggagca ggaggcactg    900
 ccatctctgg ataaacctgg ctggtactcc caagggaacg ctgtccacct ctatgaactt    960
 ctgaagaaaa tgactggcaa acctgaaccc aaggttgttt attttggtga cagcatgcat   1020
 tcagatattt tcccagctcg tcactatagt aattgggaga cagtcctcat cctggaagaa   1080
 ctcagagggg atgaaggcac gaggagtcag aggcctgagg agtcagagcc tctagagaag   1140
 aaaggaaaat atgagggacc aaaagcaaaa cctttaaata cttcatctaa aaaatggggc   1200
 tcttttttta ttgattcagt tttgggactg gaaaatacag aagactcctt ggtttataca   1260
 tggtcttgta agagaatcag tacttacagc actattgcaa ttccaagtat tgaagcaatc   1320
 gcagaattac ctctggacta caaatttaca agattctctt caagcaattc aaaaacagct   1380
 ggctactatc caaatcctcc actggtctta tcaagtgatg agacactgat atccaaataa   1440
 gttgtcttta ctgaaaaatg aagtgaagac ccatatatgc agttaaaaaa aagttaattt   1500
 tcaaaaaata ctgtaaaaga ctttaaggaa caagttttat tgaccaataa gttgatattt   1560
 gtccataggt ctcctttcta taaatcatct tgatgtttaa caactcttat tatattaaaa   1620
 tctcagtatc ctaaaactta gaaccttatt gatattttct atacagtagt tttgtgatta   1680
 gaattcacct ggggacacac actcacacgc acagtcactc ttacacatat gcctagtcca   1740
 gtggttctca aagtgtgatc catagactaa tagcatagca ttacctgaga acttgataat   1800
 gcatatttgc aggccccacg caaaacctgc tgaatcagaa gctctgagag taaggcctgc   1860
 caatctggtt taacaagccc gtcaggtgat tctgatttac agtacagttt gagacccact   1920
 ggctagaaca tatcctccag agacttggct taattggtct gggtaaatat ggctgagcgt   1980
 tgttatcttt tgttatcttt tatatgccct aggaaagtac aaccagaatt gaaaaccaac   2040
 tgatctatac cagttctttc aattaatagt caagaacatt gagtccagtg agattaagtg   2100
 atttttgcag gctatgaggt tttatgctat tcctgtgttc tcc                     2143



      <210> 2108
      <211> 541
      <212> DNA
      <213> Homo sapiens


      <400> 2108
 tttcgtgggc cactgtgtga acacagaagg tgggtttgtg tgcgagcgtg ggccgggcat     60
 gcgggtgtct gccgaccgcc acagctgcca agacactgac gaatgcctag ggactccctg    120
 tcagcagaga tgtaaaaaca gcattggcag ctacaagtgt tcctgtcgaa ctggcttcca    180
 ccttcatggc aaccggcact cctgtgtaga tacaccccaa ggattcctct ctgctcaccc    240
 attttcttgg ctgcctttgc tccccttgat gtaaacgagt gtcggaggcc attggagagg    300
 cgagtctgtc accattcctg ccacaacacc gggggcagct ttctatgcac atgccgacct    360
 ggcttcaggc tccgagctga ccgcgtgtcc tgtgaagctt tcccgaaagc cgagctggcc    420
 ccatttgcca tcctgcaacc ccggtgacac ccgtacaaga ggctactgtt gcttgctgag    480
 gccgcacggc ctgccctgtg cccaggacat agacctcctt ctggggctcc agggacatca    540
 g                                                                    541



      <210> 2109
      <211> 721
      <212> DNA
      <213> Homo sapiens


      <400> 2109
 gggtcatcct aatagaattg ttttgcgaat tgaaagagat aatacaaatg aaagccttaa     60
 agttgtccct gtcacttggt gagtggtctc ttgttgcctg atattttaaa acgtttgata    120
 tcatttcaaa gctatagaaa aattgcaaaa acagtataag aaattctcat atacccttta    180
 cccaaatttg ccaagtgttt acatttttcc tgtttgcttt gttgatgacc atcaaccaaa    240
 taccaccagg aacatacctg taaccagaga cagctgattg gtagctttct gcagcaagga    300
 agcccacata ccacggcaca attctgcttt ccctggaact gtgtcattca ggactctgca    360
 aattccctaa agtaggagga aaaatgacca tgtccaagga ggcagtgacc ttcaaggatg    420
 tggctgtggt cttcactgag gaggagctgg ggctgctgga ccctgcccag aggaagctgt    480
 accgagatgt gatgctggag aacttcagga acctgctctc agtggggcat caaccgttcc    540
 accgagatac tttccacttt ctaagggaag aaaagttttg gatgatgggg acagcaaccc    600
 aaagagaagg gaattcagga ggcaagatcc aaactgagtt ggagtctgtt ccagaagcag    660
 gagcacatga agagtggtcc tgccagcaaa tctgggaaca aattgcaaaa gacttaacca    720
 g                                                                    721



      <210> 2110
      <211> 1909
      <212> DNA
      <213> Homo sapiens


      <400> 2110
 aatttttttt ctgtattatt tatttgtgta caccagtgtc agggagtgtg gaacaactgg     60
 aaatgccaga acattagcaa ccagtagtat caaataacaa aattaaaagt atggcctaaa    120
 aggccccaga gaaagtgcac tttggggaac actcttatgt gtaaacagag cttcagtcgg    180
 ccttaggaaa ctcactcgaa gttactgata tggtctgttg gtgcttccct gtattcacat    240
 attgggaaac ttgatccccc aatgtaacag tatgaagagg gaggaccttt gggaggtcat    300
 gaggtcaggg cccttgtgac tgggattagc acccttataa ggggcctgag gaagtctgct    360
 gtttacaacc acgtgaagac acacatcaag acacaagcac tacctatgaa gaacataccc    420
 catcagacac caaatctgcc agagccttga tcttggactt cccgagcatc cagaaccatg    480
 agtgacaaat ttctattgtt tataaattac ccagtctaag gtcttttgtt acagcagcag    540
 gaagggactt aagacagttg ccttcacatt tagctgcaaa aatcactata aaaataatct    600
 gtgctcagat gtatatactt attgaatcca tgcatatttc tttctgaata tcaaacctgc    660
 tgctgtttct tttccttctt gcccctccca caatcactga agccgatttt gaccagacaa    720
 ctggccaaaa cagaagactg tttaaaataa catagtctcc cttaattaaa agttttattt    780
 ttaaaaaacg taacagacca ctctaagaaa ctttggcatt caaagcagta gttactgtta    840
 tttgctaact ctgaaaaaaa aatttttccc ctcacaaaca accggcaaac tcctgccact    900
 tcctagcttg gtggctgcca gcgtgcactg cagggaaacg gtgggtggag ggataggaag    960
 gccctcacgc tcccaaccca cggagaaaat gcagatggtg acaagctgca tctggactcc   1020
 aggatgtatc tgacaaagag ggagatgtct cctccctccc ctccaccagc tccactttcc   1080
 cgctgaagaa acagagatgt ggaggcaggc gtgacctgtc ccagctctag gacagttact   1140
 caagagggct agtctggaac cctgatgtct gttaccagcg gccatggctc agctacagtg   1200
 aaccttgaag tgtccccaga tacgtcagac accgaggggc ttgctttctg aggctcagta   1260
 aggagggggc atgtgtgatc agccagcccc tccacaaccc cacattcctg agctcccctg   1320
 accccgagtc cccaccccag gggagaactt ctcacagccc tgctgacaaa gcgcgcagcc   1380
 atctggcgtc cgtcctgggc accgccagtg agagccctgc acagaggcgc tcaggtgtga   1440
 atccgcaggt ggcgcgtcag gttcgtgttg cggctgaagg tcttcccgca ctcgccgcat   1500
 cggtagggct tctcgcccgt gtggatccgc tggtgcacag tgagggagga gttcttgatg   1560
 aaggacttcc cgcactggcc gcacctgtac ggcttctcgc cggtgtggat ccgctggtgc   1620
 tcgatgaggt aggcgctctg gctgaaggcc ttgccgcact cgccgcacac gtagggcttc   1680
 tccccggtgt gcacgatctg gtgcacgatg agggacgagc gccccgtgaa gtgcttcttg   1740
 cagatgtagc actcgtaggg cttctcgccg gtgtggatgc gctggtgctg cgtgagcgag   1800
 gagttcttgc tgaaggcctt gccgcactcg ctgcactcga aagcttcacg ccgatgtgga   1860
 agcgctggtg ctggatgagg taggagctct ggctgaaggc cttgtccga               1909



      <210> 2111
      <211> 1057
      <212> DNA
      <213> Homo sapiens


      <400> 2111
 gagaacaacc cattcctccc tccctcaagc accttggaca atctgggagg gctccccaaa     60
 ggaggtgagc accttggaca atccgggagg gcttcctgaa ggagttgatg ccacagtggt    120
 tggctttgca aagacagcaa gctttgctca cattgctctc cggggctgga acctgggcag    180
 gcatgaggcc ccctagtcag tgttggcctc aaggtcctag tacaggtaac caatccctgt    240
 ctcacggaag gggagaattg ctgacccatg ctgtgggagt ctgcatctga aaaggtcact    300
 ggggcctgag agggcagctc ccagaacagt gtgaagtgtc caggaggcca gagacaccta    360
 taggagaacc tccagatatt gcatctattt cgtctacatc ctggttgtgt cgtgccccag    420
 ggatgccagc ctcacaccgt ggctcttccg gaaggtgtgg ggccaggcct gctgcactta    480
 ctgctttggg ctaatgattc agagagtgaa gggtgctttc tccccagagg aaggagcgaa    540
 ggcctttgca ggagatgaca cactgacgaa ggtttcccat gccctctcca agaaaactga    600
 tggacaacgg ggctgcatcc tgggcggggg cttacctggg aaccacgtgg gaccaggtcc    660
 ggagaaccat cctctagcca gctcgtcttg gcaagtgtcg tccaacccag tgctagctga    720
 tagaaccttc tgcaacgatg ggaatgttct gtacctggat aaccccctgg cacagatgac    780
 tactgggtac tggaaatgtg gccacaagga accaaatttt tcattgtgtt tcatcgtaat    840
 ttaaattcac atggccctgg gtggccagta gcgctcacat tggacaaaac agctctatcg    900
 tcatcatctg tgctctaccg gttttcttgg tggctaattt gtaaactggt tttggcttca    960
 tgcctgcgta agaactgcaa gcactagtag tttatgcctg gttttacatt ttgtgcctgt   1020
 cgaagtgaca ttataagaaa agacactata tggtctt                            1057



      <210> 2112
      <211> 1245
      <212> DNA
      <213> Homo sapiens


      <400> 2112
 tggaagaagg gagtgagact gctcagagag gcaggattcc tgctgactcc agggggacac     60
 ctggcacctc agcttccttt cccacttctc caggctgcat ggaggggtgc cgggcagggg    120
 cctcctggaa gggaacctcc tgcagcctca agcaccaggt catgacatga catctatccc    180
 tttcccaggt gaccgactcc tgcaggtgga tggagtgatt ctgtgcggcc tcacccacaa    240
 gcaggctgtg cagtgcctga agggtcctgg gcaggttgca agactggtct tagagagaag    300
 agtccccagg agtacacagc agtgtccttc tgctaatgac agcatgggag atgaacgcac    360
 ggctgtttcc ttggtaacag ccttgcctgg caggccttcg agctgtgtct cggtgacaga    420
 tggtcctaag ttttgaagtt caaactaaaa aagaattgcc aatggtttgg gattcagttt    480
 cgtgcagatg gagaaagaga gctgcagcca tctcaaaagt gatcttgtga ggattaagag    540
 gctctttccg gggcatccag ctgaggagaa tggggccatt gcagctggtg acattatcct    600
 gggccgtgaa tgggaaggtc cacggaaagc ctcatcttcc aggtgccggg ggtcatgggc    660
 aatgcagctc tctgtgcagg ctggccccag ctttgcctct tactatcctg ctgccgtgga    720
 ggtgctgcat ttactgagag gggccccaca ggaagtcacg ctcctccttt gccgaccccc    780
 tccaggtgcg ctgcctgagc tggagcagga atggcagaca cctgaactct cagctgacaa    840
 agaattcacc agggcaacat gtactgactc atgtaccagc cccatcctgg gatcaagagg    900
 acagctggga gggacagtgc ctccccagat gcaggggaag gcctggggtc tcaggccaga    960
 gtcttcccaa aaggccatca gagagggcac aatgggggcc aaaacagaga gagaccttgg   1020
 gccagttcct tgacacattc tcctgagtcc caccctcatt tatgcaaact tcaccaagaa   1080
 agggatgaat caacattggc gacctctttg gaaaaggatg tgaggcaaaa ctgctattca   1140
 gtttgtgata tcatgagact tggaagatat tccttctcat ctcctctaac cagactttcg   1200
 acagatattt tctgagcacc ttctctgcat gtctgcagtg ctgtg                   1245



      <210> 2113
      <211> 1145
      <212> DNA
      <213> Homo sapiens


      <400> 2113
 acattgcggt ggacttctct tccttcgatg ccatcactgt aggtaagaag gtcccactgg     60
 tgctttgctt ctttctctcc ttccatatct cttagtgtct ccagagctgc agtacaagtt    120
 ggggggatgg actgtaaaag ccagaaatcc caagccacaa gcacgctgca ggtagcaacc    180
 ccacacccag caaaacaccg cttcttcctg cccactttcc cctctgcgcc aactgtacac    240
 accataccct atgcttgtcc atttgggaaa ctggcttcca ggacagcatc tttcctggaa    300
 agacagcagg aagctgatgg tcactcctca actctctctt gtctctgggc agacaggcaa    360
 cagcaactgt acatttttaa agggagccat ttctgggagg tggcagctga tggcaacgtc    420
 tcagagcccc gtccactgca ggaaagatgg gtcgggctgc cccccaacat tgaggctgcg    480
 gcagtgtcat tgaatgatgg agatttctac ttcttcaaag ggggtcgatg ctggaggttc    540
 cggggcccca agccagtgtg gggtctccca cagctgtgcc gggcaggggg cctgccccgc    600
 catcctgacg ccgccctctt cttccctcct ctgcgccgcc tcatcctctt caagggtgcc    660
 cgctactacg tgctggcccg agggggactg caagtggagc cctactaccc ccgaagtctg    720
 caggactggg gaggcatccc tgaggaggtc agcggcgccc tgccgaggcc cgatggctcc    780
 atcatcttct tccgagatga ccgctactgg cgcctcgacc aggccaaact gcaggcaacc    840
 acctcgggcc gctgggccac cgagctgccc tggatgggct gctggcatgc caactcgggg    900
 agcgccctgt tctgaaggca cctcctcacc tcagaaactg gtggtgctct cagggcaaaa    960
 tcatgttccc cacccccggg gcagaacccc tcttagaagc ctctgagtcc ctctgcagaa   1020
 gaccgggcag caaagcctcc atctggaagt ctgtctgcca aagttccttg aagaatgcag   1080
 cattgtcttt gtctgttccc accacatgga ggtgggggtg ggatcaatct taggaaaaag   1140
 caaag                                                               1145



      <210> 2114
      <211> 474
      <212> DNA
      <213> Homo sapiens


      <400> 2114
 cactggtccc accatcaaga atatggatgg cacatttaat gtcactagct gcttgaagct     60
 gaactcctct caggaagacc ctgggactgt ctaccagtgt gtggtacggc atgcgtcctt    120
 gcataccccc ttgaggagca actttaccct gactgctgct cggcacagtc tttctgaaac    180
 tgagaagaca gataattttt ccattcattg gtggcctatt tcattcattg gtgttggact    240
 ggttttatta attgttttga ttccttggaa aaagatatgt aacaaatcat cttcagccta    300
 tactcctctc aagtgcattc tgaaacactg gaactccttt gacactcaga ctctgaagaa    360
 agagcacctc atattctttt gcactcgggc atggccgtct taccagctgc aggatgggga    420
 ggcttggcct cctgagggaa gtgttaatat taatacatat tcaacaactg tatt          474



      <210> 2115
      <211> 1148
      <212> DNA
      <213> Homo sapiens


      <400> 2115
 agtcatgcga tgaccatgat tacgtctagc ctggccgcag gcctagcacg cacctattgc     60
 tgacaccctg agtttaattt tgttacccgc cgtgcggcac acgtgggata aaagctgaag    120
 gaggactgta acaacactga caacaaagaa cggaagtcct tccagaagga gcttgggatg    180
 gccctactga agatggactg ccagggcctg gtggtcagac tcatccagga ctttgtgctc    240
 ctgaccacgg ctgtagaggt ggcccagcgc tggcgggagc tggctgagaa gctggccaag    300
 gtctccaagc agcagatgga cgcctacgag tctccccacc gggacaggaa cggggttgtg    360
 gacagcgagg ccatgtggaa gcctgcgtat gacttcttac tcacctggag ccatcagatc    420
 ggggacagct accgggatgt catccaggag ctgcacctgg gcctggacaa gatgaaaaac    480
 cccatcacca agcgctggaa gcacctcact gggactctga tcttggtgaa ctccctggac    540
 gttctgagag cagccgcctt cagccctgcg gaccaggacg acttcgtgat ttgaatgggt    600
 cccctcccct cctgctgctc tggagtgcaa gccctcttct gccctgcgtg ccctgctgtc    660
 accgcggagc tgaagaggga ggaaggggcg gctgctcaga cagatttagg gcccgccagc    720
 taggctacac ccatcatgcg ccgccctcct ccatcgaggg agaggcctga agggactgcc    780
 tactgcagct cgttgccaat cacatagctt tctatttgtt aagtataaat ttaaatttaa    840
 aatcactttt ttaacgaatg gggggaaggg atctatgaga aaggtggtat ctaatttttt    900
 tatggaccat aaaggtttaa aagaaaatag gggcacaggg tgttgaggtt tttatgttgt    960
 tatagacctt tttaaattat gttagagatg tatataggta tttaaaggtc actgggagca   1020
 tttctgattc ccgggccaca cttttgcatt tcaacactca agcccgggaa aagatgctcg   1080
 ttcggatgtt gtacctcttt cactccctgc gagtagcact gtgaatgacg tattaaaaag   1140
 tggctttt                                                            1148



      <210> 2116
      <211> 1251
      <212> DNA
      <213> Homo sapiens


      <400> 2116
 tttttaagag gttcatgaca caaatatatt tatattaggt gaatcaatca cccaggatac     60
 ccaagatctg atactttcac aaactgcttg gaggcaactt aagtatggaa gaagcttcag    120
 aaccagccca gctttctgct ctctggctcc aggctgcatc ctttttaact atttaatgtg    180
 gcgtggaaaa tgtcagcata atgaggcttt ctcatctcaa tagagaacct aggaaggaca    240
 aggccgaatt aaaaaaaaaa tcttcattaa agaatttaat agggagttga ttatgttgta    300
 gaatcatatc gtcctattct gtgacacatt agaaacataa actttagggc tttttcatct    360
 ccacagcata gaggtctgat cgcttctgtc taaaaacggg gatttgctgg cgtatttcag    420
 ccagcttctt caggtctatg tctgaataca cgattgcttc ttctgtgcca gctttggcta    480
 gaacctcccc ccaagggttc accacggtgc tgtgtcccca ggcaacatag gaggctttgt    540
 catcccgggc aggagaggct gtggccacat acacctgatt atcaacagcc cggcttcgct    600
 gaagtaactc ccaatgggct ggtccagtgg tcagattaaa agctcctgga tataccaaca    660
 gctggcagcc tctctgtgcg tagatttgtg caagctctgc aaaccgcatg tcgtagcaga    720
 tgcccagacc cactctgcag taaggagtat caaatgtgga gaaactatca cccggactca    780
 atgttttaga ttcttgaaat gtaatttttc caggaacatc aatgtcaaac agatggatct    840
 ttctatactt tgctagtaaa gttccatcag gcccaaacac agcacaggtg ttatataatt    900
 tcccagcatc ctcttcaggg atagagcctc caatgagata tatgctgcat tcctttgcta    960
 cttcagaaag cttctgtgtg gattcaccag gaattttctc tgcatattca ggaaaatatt   1020
 tcgctccata tggagaatta aagcattccg gcaaagaaac tattttggct ccttgcgttg   1080
 ctgcctcccg gatgaagcta caagcgcgag tgacgttatc tgatttgatg gaagaaatct   1140
 gaagctggat gagggccaag cggaaagagg tcatgactct gcagacaagc accacctgcg   1200
 gcgcggaatg agcgctggag atccggcgga ccgcggcgtc gctacacgaa a            1251



      <210> 2117
      <211> 857
      <212> DNA
      <213> Homo sapiens


      <400> 2117
 agctgtctcc atttgctaaa gctataaaca gttcttgatc tagtcaattg caaaatacat     60
 ggatggccag ggcttctgtt taagcaaaag aagaaaaaat atcaatagca caaaactgcc    120
 cttatagttt ttgaaaaaat atatctatta agataacaat tttgattttt ttaataagct    180
 gtgcattaaa gtacactttg tttccatcac tctccattac tctagagctc cgctttgtct    240
 gcctgggccg ggctggcgac cccactgcct ccctcggcgg tgccactgct atccgcaggt    300
 gtaaaagaca aggcagccga atttatgcag tatcttttcc cagttggacg aggcccatca    360
 tcaaaaatgt gcccaaggtg agcaccacac tgagagcagc ttgtttccac cctgtgcatc    420
 ccataggaaa agtcatctgt gaatgtgatt gcctcagaat tgatcacatc gtggaatgaa    480
 ggccaacctg aaccggagtc aaatttggtt tctgacttaa acaatggagt tccacaaaca    540
 acacatttat atattccagg atctttgtga tgtgtgtatt ctccttcaaa ggcactttcg    600
 gtccctttct cctgagtgac atggtactgc aggggtgtta gccgcttcct cagttcctgc    660
 tgggaaaaga ccaccttaca gttcttttta tccctacacg acccggactg cgcacttccc    720
 agagccgcgg ccaggcagag gcagaggcag agggagaggc agagcgagag ggggcgcggg    780
 agggtccgcc gcgggctcat ggaaaggcca ggcagccacc gccggtgtca gaacctcgct    840
 ccctccctcc ccggctc                                                   857



      <210> 2118
      <211> 1599
      <212> DNA
      <213> Homo sapiens


      <400> 2118
 tttgcaaacg ccacagtgat gccctgcaga aaagctgtgg cagaatcccc ttgatagtcc     60
 ccagcactct tcacatcact ctccccatca ccagacaacc acatcagagc ctgactgacg    120
 atgagatgca ggtaaaggta acaagacaag gcccaggctc gcaagcttct gtccccaaaa    180
 ggccacctgc ttgacagcca caggtgtcac agctgtaact gggttcattt tggccaagag    240
 ataggtaaag tttaaaatat tgataccctg ttaactataa tttcataact cctatttttt    300
 aaagataatt tcttcaaatt ccaaaagttt taaacagcaa cagcaaattg ttactggtgt    360
 taacaaattg ttaaacagca acagcaaact cttactgtgg ctggtcacca cagtgtagat    420
 acagtccggg ctttctctgt gctttgcaga cctcagtgag acaccagagg gcagggcagg    480
 tgtcccaggg tgcccacact cgtgtgacgg tgtggcatca ggcaggccct gcagtcccag    540
 ttctgctggt taacctgcca catgcacttc tgtcctgaca cacaaggacg gcagggcaag    600
 accgtaaacc atgaccttgt ctttgtaaag aaaggcccag agcctgagaa aagcaggcct    660
 ttagcaggaa gggctctgcc ctcctcacct cagagcaaat ccatttgccg cgttctgaag    720
 ctcattaata gacctcctca ggccaaagag aacaatgtcc ccaccaaccc tccctaacag    780
 tcacagatac acttcattgt ccggacttac aggtcagtta atcagaagcc tgagctctgg    840
 aatattgtca aagaaatgga gttttgagta gtgagtacat ggtgtactct cccaaatgca    900
 gcctaatctt agtaaccttg aagtttatca ttctttaaaa ataaatagaa taccaatggt    960
 ttagatattc caacaaagaa tgctagaaac aaatgtctaa tctcgattat tagctttacc   1020
 aaccctgtga acactgaggt tgcagaactg ccaggttaat ccctgtggcc tagactactg   1080
 aggattctga tagcacatgt aagactaagc actcttcaag ctgtaataaa gcatccacat   1140
 gtatctgtga tgattttcat tgctttagca ttgcagccat gtaacaactg cagaaagaag   1200
 gtatttttaa aaatacaata gactacactt tttggatcac agagaaatac agatgcactc   1260
 tgagactgcc tatgtttata aacatgttgt gtcccctaac tgaagtgaca ggtcttctgg   1320
 aattgacatt aagaagtgtg gatagtcata tcacacgcaa tgtatttgtt ttcagcagtg   1380
 agcagaccgt acaggagcag cacaccagga gccatgagaa gtgccttgga aaccaacagg   1440
 gaaacagaac tatctttata cacatcccct catggacaag agatttattt ttgcagacag   1500
 actcttccat aagtcctttg agttttgtat gttgttgaca gtttgcagat atatattcga   1560
 taaatcagtg tacttgacag tgttatctgt cacttattt                          1599



      <210> 2119
      <211> 421
      <212> DNA
      <213> Homo sapiens


      <400> 2119
 cggacgcgtg ggcagagcag catatctcca tcattggcat tcaccatcac tatgaagggc     60
 ttcactgctt ttgccatcct tggtctagca gtcactgctt gggctacctc gccatatggg    120
 acaaagagat caagaatttc aactcagaaa acttcatgaa ggtaaatgta ttcagtgtac    180
 caggtattct gaggcatgta ccatggacta cacacttcac tgtggatctg atggaaatgt    240
 atattccaac agatgtacct tttgcaatac cgttgtgaag agccaaggtg caatttggtt    300
 gaaaaattat ggattgtgct gaatctccct gatgcttaag gatatcaagt ctcctttggc    360
 agattccact tagataacca gtttgtcttg gacggctgag gaggcaagca ataatctggt    420
 a                                                                    421



      <210> 2120
      <211> 184
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> misc_feature
      <222> (1)...(184)
      <223> n = a,t,c or g


      <400> 2120
 ttgggatgag gaaaggaaat tgagcagaag gtacaggagt aatagcaatt ccctgtagct     60
 ctcaaagcaa attttgagct catttttctt tttctgcaag ctnagnagca gaatgcccag    120
 agtcttccct ggtagatgca ggttccatag cgacgttctc ctgcaatgca cgtcgacgcg    180
 gccg                                                                 184



      <210> 2121
      <211> 1887
      <212> DNA
      <213> Homo sapiens


      <400> 2121
 tttttttttt ttgtttaaaa aaagttttta ttaatgtgtt aatatttcag caaagttatt     60
 gcaacaggtt gaaaatgcag acacactatt acaggctgta aagtaacaaa tgagttttac    120
 acaattaaaa tattaacaca tacttatggg atttgttgaa tgactaacag acccataaaa    180
 gaaattaaat ctgagacgaa atccagtatt agcacctaca atatatctga cagtgaaact    240
 tttaatggtt tctctctcct aatgtatttt taaactctct cccaaataca gcgctctcaa    300
 accccaagga taaacgaaag gcataagcag ccccgatcct aggaacgtac agccaaaagc    360
 agagctacaa atatggactc agacttgaga gttttactga gaagtaactt actgtacttg    420
 agccaatcat aagatttctg tgcactgaat actgtatatg agaaaattct gtgggtcata    480
 aggtttgcct tagggatagt taaaaattag taatatacag tattattcct atcaaatttt    540
 tttctcataa gttatattta taacaaaact ataattaaaa tattttttat acctgcttat    600
 tccatatcca gggacacagc gggaacatct atgtgtctga tggtttggca tccactttat    660
 tgtgcttact gatttttgtg atgaacaagc agcacgtatc atatctttcc aacattcaag    720
 gtaatggaac aatgacataa aattctccaa agaaataact ggaaattgca ttaaatactg    780
 ctttaattag gaataattgc tataataaaa caaataacat tatacatttt tttttcaata    840
 agcttcagtt tgaggaactg aatagtagaa acagatctta agatttgagt catggtaaaa    900
 ccagtaattc tttgaaatct gggaggtgca aaacgacagc cacagccaac cctcaccaaa    960
 atcctggaga aaaacatttt attaatttag gggaacaaga tagaacactg gtgaagatac   1020
 ggcttgttga ggtctaaagc cacctgagaa gctggcccaa ggaatgaaga gaaccaatgg   1080
 tatgtactgg tggcagataa caagctttgc actgggctga ccaactgtgt tttattaaat   1140
 ggctttgaat aaaaaaaagt gaagtgcttc attgtgtttt ctcagaaact aatcaaaaga   1200
 ttacagagtc ctacacaatt tggagacaca aagtggatgc tgagcgacta gaggtcactc   1260
 caggtgtgga attttagaaa gtgagtcctt ggagtaaatg gcaccgtggc tctggcagca   1320
 gatagaaagg aatgatgctc tggagaggag gtagggacac tctgcggtcg gccagtggat   1380
 acatgagggg cccggctgga agtgggatct ttaattcttc ggtttatctt ccactgctca   1440
 tgcctctgtc ttcataaatg gtaatttcaa taactcgcag tcctcgctca atagggtctg   1500
 tcaggaggag gccttgtgga gcatagatct tctcattctg ctcttgaatg tatttggaga   1560
 ctttcttcag aaccttctca taatgagttt ccatgcatag gaagatggta tatgctgtta   1620
 aacaagccaa acaaccttcg agatatgact ggccgccgag cttctctgct tctgcataaa   1680
 ggttatttag agttcgaact gtttcttcaa actgctgcct atcaatccgg ttctccagct   1740
 ccgcagggaa cttggtctgg aactggcagc gtgtgccact gctgtagtct cgctgaatga   1800
 acacctttcc ggacaccggc gcctgctgcg gcctcatggc gaggacagga caccccgcgc   1860
 cgcctcctct gccctccagc tgctgtc                                       1887



      <210> 2122
      <211> 676
      <212> DNA
      <213> Homo sapiens


      <400> 2122
 gggtcgaccc acgcgtccga cggattaggg gcataagtca cctgatgctt tggctgaggt     60
 ttggaaggtg cctgattcat tgcgaaaggc tcttataaat tcatccattg ggctcaccta    120
 ccctttaggg aagtaatctt tcccaatgtg gtctcagaaa taaagtggat tgacagcatg    180
 ccatctcaac gatgaagaga agctccactg agcaatactg tgccccagga gatgtcataa    240
 ctgcacacct gtgtgcctac atcttgctgc ttcttatcac aaaacaaagg agtttgttca    300
 agaggtattt ccaaatgccc agcattccca actgaagtgg cctttgcctt ggacatgtca    360
 aatgatgtct ccctgttgga ttttgagagg atgagagaca ttttattgtc tctgttgatg    420
 aagatggaaa taagtgacag taactgccca acaggtgccc gtgtggccat tgtttcctac    480
 aatgccaaaa ccaattactt ggttcgtttc tcagactaca aggggaaggt tgcactcctg    540
 gaggctgtca ggaacatccc cctggagcag tcatctggcc gcaggaacct cggggccacc    600
 atgaggttta tggcgagacg tgttcaaacg tgtacgctcg ggtcttctca tgaggaaggt    660
 ggctgtgttc ttccag                                                    676



      <210> 2123
      <211> 720
      <212> DNA
      <213> Homo sapiens


      <400> 2123
 ctcgcatcct ctagagcggc cgcaatacat ggggtcagtg ggggtgggcg gcgggcaggc     60
 gggcgttccg ggctcacatg agggtgcatt tgcccttgac gcggtctgtc ctcttctgct    120
 tcccggagcg cttgccgtcg atgttgaggc tcatgttccg gcgcgtctcc agcgtcagca    180
 gctcctggaa gagctccttg acgttgtagt tcatcttggc cgaggtctcc atgaaagcgc    240
 acttccactc ctgggccacc gcctgcgcct cgcgcgtgtc cacctcccgc tgcgtctcat    300
 cgcacttgtt gcccacgagc atcacgggga tgtcctccac gctgcccttg atctgcacga    360
 tgagcttgta gatgggcccc agctcctcca gcgactgctt gctggtgacg gagaacacca    420
 ggatgaaggc gtggcccttg gagatggaca ggcgctgcat ggccgggaac tggtggctgc    480
 cggtggtgtc tgtgatctgc agcgtgcaca cgctcttgtc gcagctgatc atctgccggt    540
 aggtgtcctc gatggtgggg atgtaggtgt cgcggaacgt gcccttcacg aagcgcagca    600
 ccagcgagct cttgcccacg ccgcccgccc cgaacaccac cacgcggtaa tcgttactct    660
 gttccggcat cttccccgcg gcgggtgggc ggccggggcc gggagggctg gtgccagctg    720



      <210> 2124
      <211> 401
      <212> DNA
      <213> Homo sapiens


      <400> 2124
 tttcgtctgg cgtggacgtt tgtggtgggg cgtgttggtc cgcgctctca gaactgtgct     60
 gggaaggatg gtagggcgac tggggctcac ctccgcaccg ttgtaggacc cggggtaggg    120
 ttttgagccc gtgggagctg ccccacgcgg cctcgtcctg ccaacggtcg gatggcggag    180
 acgaaggacg cagcgcagat gttggtgacc ttcaaggatg tggctgtgac ctttacccgg    240
 gaggagtgga gacagctgga cctggcccag aggaccctgt accgagaggt gatgctggag    300
 acctgtgggc ttctggtttc actagggcat cgggttccca aaccagagtt ggtccacctg    360
 ctaaagcatg ggcaggagct gtggatagtg aagagaggcc t                        401



      <210> 2125
      <211> 1286
      <212> DNA
      <213> Homo sapiens


      <400> 2125
 gaagtagtag gcaatgagcc agaaggggtc ctcagtcagt ttcgggagca ctggtgtgga     60
 gtggatgaag ccagtgagga cacagtggag acagtggagc accagagaac ccagggcaag    120
 gaagctgggc agccgggccc ttcaccagtc aggccacctg cagtctgcag tcagagcctc    180
 agatcttaca ctggcagcac acggggacac agcagctgga ctggcagcag cagggcttgt    240
 agcagctgga ttggcagcag gatgatccac agcctgagaa gcagctacag ggcttacagc    300
 agctggactg gcagcagtag ggcttacagc agctggactg gcagcaggat gacccacagc    360
 ctgaggagca gcagcagggc ttgcagcagc tggactggga gcaggatgat ccacagcctg    420
 aggagcagca acagggctta caacagctgg actgggagca gccacaagaa ccacatcccc    480
 ccttggaacc cccacaggag ccacagcccc ccttggagcc cccacaggag ccacagctgg    540
 tgcaggaaca ggctggcacc caggagcaca cgggcttgca gcagcagaca ggcacataac    600
 atctggagcc acatccccca cagctggagc tgcagccccc acagccagag ccacagcccc    660
 cacggccgga gccacagccc ccacagccag agccacaacc cccacagctg gagccacagc    720
 ccccacagcc ggagccacag cctctggagc agccacagca gcccatggtt ctggtggatt    780
 gagggtggag caggtagagg agcaggtgag agggaggtgc aggtgtggag ctccctgagc    840
 ctgggctctt tatatacctg tccagatgtc aggcatgaca cagggtccct ttcttgtgac    900
 tgtttacact atttttccag agctctattt ttttcctctt tgctagtgac ttccttctgg    960
 ctcagttgag catctacttt ctttgttttc taaatttgtc tttttcccca tttgttttgg   1020
 cccctacaat taaaacctca gctccaggct gtctggttct tcctgcaaag ctccagggtg   1080
 ctggtcacct gctctctgct gaccacatgt gaccaatggg caacagcctc tgcccacgtg   1140
 ctctaatctt tcctgtgttg actccctcaa taatattaat tttacatttt tagatttcaa   1200
 aattatccac gatctttata ctcatgccag tctcagcttt ccgggtgtgt tagaccattc   1260
 tttgcattgc tctaaagaaa tacttg                                        1286



      <210> 2126
      <211> 410
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> misc_feature
      <222> (1)...(410)
      <223> n = a,t,c or g


      <400> 2126
 acttcactct cttgaaaacc cacccagatc ctccccgttc tgacaccatg gtcagctcct     60
 gttgtggctc cgtgtgctct gaccagggct gcggccaaga cctctgtcag gagacctgct    120
 gccgccccag ctgctgtgag accacctgct gcaggaccac ctgctgccgc cccagctgtt    180
 gtgtatccag ctgctgcagg ccccagtgct gccagtctgt gtgctgccaa cccacttgtt    240
 cccgccccag ctgctgtcag accacctgtt gcaggaccac ctgctaccgc cccagctgtt    300
 gtgtgtccag ctgctgcagg ccccagtgct gccagcctgt gtgctgccaa cccacctgct    360
 gtcgccccag ctgctgtgag acgacctgct gccaccctan gtgctgcatc               410



      <210> 2127
      <211> 387
      <212> DNA
      <213> Homo sapiens


      <400> 2127
 cccagatcct ccccgttctg acaccatggt cagctcctgt tgtggctccg tgtgctctga     60
 ccagggctgc ggccaagtcc tctgtcagga gacctgctgc cgccccagct gctgtcagac    120
 cacctgttgc aggaccacct gctaccgccc cagctgttgt gtgtccagct gctgcaggcc    180
 ccagtgctgc cagtctgtgt gctgccaacc cacctgctgt cgccccagct gctgtgagac    240
 gacctgctgc caccctaggt gctgcatctc cagctgctgc cgccccagct gctgtatgtc    300
 cagctgctgc aagccccagt gctgccagtc tgtgtgctgc cagcccacct gctgccaccc    360
 cagctgctgc atctccagct gctgtcg                                        387



      <210> 2128
      <211> 1534
      <212> DNA
      <213> Homo sapiens


      <400> 2128
 cgacgatttc gtggcgagtc cggggcagga agaacgcacg gatggagaca acaggaagga     60
 aagagacctt cctggtcaca cttgggccac aggagaacag gcagcggccc aggaggatcc    120
 agggtcctga tggtggttga gaagctggtt cttagtgatc actcagaaac gtcggcctgg    180
 ccttgtgggg tcagaccttg catctcagtc agcccaggga gaagaagaag atggtccaca    240
 cccaagtgca gggaacatcg tggcagtcgg ctgggtgcct gcgtccaggc gaggacacct    300
 cccgcatcag ggaaacacac gtttctggag tgaggaggct gaaggcaggg cccagaggag    360
 agctgagcca tggaaggagg tgtgtgcatg gatggtgagc tagagcaggt gcaggtgcct    420
 cagggaggat gtgtgggacg aactgactca gggaaccata agaaatgctt tcaccaaaca    480
 ggagaaacct gaaggtctgg gtccagagcc tcagatctta cactggcagc acacagggac    540
 acaacagttg gactggcagc aacagggctt gcagcagctg gactggcagc acacggggac    600
 acagcagctg gactggcagc agcagggctt gcagcagctg gactggcagc aggatgatcc    660
 acagcctgag gagcagcaac agggcttaca acagctggac tgggagcagc cacaagaacc    720
 acatcccccc ttggaacccc cacaggagcc acagcccccc ttggagcccc cacaggagcc    780
 acagctggtg caggaacagg ctggcaccca ggagcacacg ggcttgcagc agcagacagg    840
 cacataacat ctggagccac atcccccaca gctggagctg cagcccccac agccagagcc    900
 acagccccca cggccggagc cacagccccc acagccagag ccacaacccc cacagctgga    960
 gccacagccc ccacagccgg agccacagcc tctggagcag ccacagcagc ccatggttct   1020
 ggtggattga gggtggagca ggtagaggag caggtgagag ggaggtgcag gtgtggagct   1080
 ccctgagcct gggctcttta tatacctgtc cagatgtcag gcatgacaca gggtcccttt   1140
 cttgtgactg tttacactat ttttccagag ctctattttt ttcctctttg ctagtgactt   1200
 ccttctggct cagttgagca tctactttct ttgttttcta aatttgtctt tttccccatt   1260
 tgttttggcc cctacaatta aaacctcagc tccaggctgt ctggttcttc ctgcaaagct   1320
 ccagggtgct ggtcacctgc tctctgctga ccacatgtga ccaatgggca acagcctctg   1380
 cccacgtgct ctaatctttc ctgtgttgac tccctcaata atattaattt tacattttta   1440
 gatttcaaaa ttatccacga tctttatact catgccagtc tcagctttcc gggtgtgtta   1500
 gaccattctt tgcattgctc taaagaaata cttg                               1534



      <210> 2129
      <211> 697
      <212> DNA
      <213> Homo sapiens


      <400> 2129
 tttgtacgtc cactatccat gtggtggaat tctgatgaga gactttacga atgtacagaa     60
 tgtgggaagg catttaacaa tcgctcaact cttattcagc atcagagaat tcacactggt    120
 gagaagtcct ttgaatgtaa ggaatgtggc aaagcattca ataattgctc aacacttact    180
 caacaccaga gaactcatac taatgagaaa tcttatgaat gtcaggaatg taaaaaggct    240
 tttaggcaaa gtgcacatct tactcaacat caaagaattc atactggtga gaaaccatat    300
 gagtgtaagt aatgtgggaa ggctttcact tgtgtttctg attttaatag acatcagaga    360
 attcacactg gtgaaaaacc ctatgaatgt aaagaatgtg gtagagcttt taacaattgt    420
 tcagctctta ttcaacacca gagaattcac actggtgaga aggcttatga atataagcag    480
 tgtgggaagg tttttgtctc ctgtccaaca cttgttcaac atcagagaac acatactaat    540
 gaaaaacctt atgaatgtca gtaatgcaag aaggccttca agcataatgc acatctaatg    600
 agacatcaga gaattcacag tggggagaaa ccctatgaat gtaatgaatg tgggaatgcc    660
 ttcatttgtt tttttgattt taatagacat cagagaa                             697



      <210> 2130
      <211> 394
      <212> DNA
      <213> Homo sapiens


      <400> 2130
 cactatctcc agccccatac ctctcttcag ggctccatac ctgtgcttct agttgtctgc     60
 cagacatgtc catttttcat tgcccaactg gcaacttatt gtctgattgt ctatctagtt    120
 gtacatccta gaaatcatag tcataattta ttccatcttc acttccccat actcatagat    180
 aaccaagtcc cataaattgg aaattctaag ttgccaatgg aaaaacaaat aacaaagata    240
 ctggtctggg gttaggagag tgttcgcagt catcatactc ctcttggcca gcagtgtccc    300
 acgtgttcag gctaacgatt tgcccatcca cggatgtctg gacgctataa ttgtcaaaga    360
 cagtgggggg atatactcct caggaaagac attt                                394



      <210> 2131
      <211> 3464
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> misc_feature
      <222> (1)...(3464)
      <223> n = a,t,c or g


      <400> 2131
 atgcagtggt cagtgataat ggaatacttg aaagtaatcc cctcactcca ggaactagtg     60
 ctcagctagc agaactaata gccctcactt gggcactaga attaggagaa gaaaaaaggg    120
 caaatatata tacagactct aaatatgctt acctagtcct ccatgcccat gcagcaatat    180
 ggaaagaaag ggaattccta acttctgaga gaacacctat caaacatcag gaagccatta    240
 ggaaattatt attggctgta cagaaaccta aagaggtggc agtcttacac tgccggggtc    300
 atcanaaagg aaaggaaagg gaaaatactt ttgcctgcaa ctatccaatg gaaattactt    360
 aaaacccttc atcaaacctt tcacttaggc atcgatagca cccatcaaat ggccaaatca    420
 ttatttactg gaccaggcct tttcaaaact atcaagcaaa tattcagggc ctgtgaattg    480
 tgccaaaaaa ataatcccct gcctcatcgc caagctcctt caggaaaaca aaaaacaggc    540
 cattaccctg aaaaaaactg gcaactgatt ttacccacaa gcccaaacct cagggatttc    600
 agtatctact agtctgggta aatactttca cgggttgggc aaaggccttc ccctgtagga    660
 cagaaaaggc ccaagaggta ataaaggcac tagttcatga aataattccc agattcggac    720
 ttccccgagg cttacagagt gacaatagcc ctgctttcca ggccacagta acccagggag    780
 tatcccaggc gttaggtata cgatatcact tacactgcgc ctgaaggcca cagtcctcag    840
 ggaaggtcga gaaaatgaat gaaatactca aaggacatct aaaaaagcaa acccaggaaa    900
 cccacctcac atggcctgct ctgttgccta tagccttaaa aagaatctgc aactttcccc    960
 aaaaagcagg acttagccca tacgaaatgc tgtatggaag gcccttcata accaatgacc   1020
 ttgtgcttga cccaagacag ccaacttagt tgcagacatc acctccttag ccaaatatca   1080
 acaagttctt aaaacattac aaggaaccta tccctgagaa gagggaaaag aactattcca   1140
 cccttgtgac atggtattag tcaagtccct tctctctaat tccccatccc taggatacat   1200
 cctgggggaa gggaccctta cccagttcat ttttatttta ccccaattgc gggtttaaag   1260
 tggctggagt ggtcttggat acatcacact tgagtcaaat cctggatact gccaaaggaa   1320
 cctgaaaatc caggagacaa cgctagctat tcctgtgaac ctctagagga tttgcgcctg   1380
 ctcttcaaac aacaaccagg aggaaagtaa ctaaaatcat aaatccccca tggccctccc   1440
 ttatcatatt tttctcttta ctgttctttt accctctttc actctcactg caccccctcc   1500
 atgccgctgt atgaccagta gctcccctta ccaagagttt ctatggagaa tgcagcgtcc   1560
 cggaaatatt gatgccccat cgtataggag tctttctaag ggaaccccca ccttcactgc   1620
 ccacacccat atgccccgca actgctatca ctctgccact ctttgcatgc atgcaaatac   1680
 tcattattgg acaggaaaaa tgattaatcc tagttgtcct ggaggacttg gagtcactgt   1740
 ctgtcggact tacttcaccc aaactggtat gtctgatggg ggtggagttc aagatcaggc   1800
 aagagaaaaa catgtaaaag aagcaatctc ccaactgacc cggggacata gcacccctag   1860
 cccctacaaa ggactagttc tctcaaaact acatgaaacc ctccgtaccc atactcgcct   1920
 ggtaagccta tttaatacca ccctcactgg gctccatgag gtctcggccc aaaaccctac   1980
 taactgttgg atatgcctcc ccctgaactt caggccatat gtttcaatcc ctgtacctga   2040
 acaatggaac aacttcagca cagaaataaa caccacttcc gttttagtag gacctcttgt   2100
 ttccaatctg gaaataaccc atacctcaaa cctcacctgt gtaaaattta gcaatactac   2160
 atacacaacc aactcccaat gcatcaggtg ggtaactcct cccacacaaa tagtctgcct   2220
 accctcagga atattttttg tctgtggtac ctcagcctat cgttgtttga atggctcttc   2280
 agaatctatg tgcttcctct cattcttagt gccccctatg accatctaca ctgaacaaga   2340
 tttatacagt tatgtcaata tcctaaagcc cccgcaacaa aagagtaccc attcttcctt   2400
 ttgttattgg agcaggagta ctaggcggac taggtactgg cattggcggt attacaacct   2460
 ctactcagtt ctaccacaaa ctatctcaag aactaaatgg tgacatggaa caggtcgccc   2520
 gactcccctg gtcaccttgc aagatcaact taactcccta gcagcagtag tccttcaaaa   2580
 tcgaagagct ttagacttgc taaccgctga aagaggggga acctgtttac ttttagggga   2640
 agaatgctgt tactatgtta atcaatccgg aatcgtcact gagaaagtta aagaaattcg   2700
 agatcgaata caacgtagag cagaggagct tcgaaacact ggaccctggg gcctcctcag   2760
 ccaatggatg ccctggattc tccccttctt aggacctcta gcagctataa tattgctact   2820
 cctctttgga ccctgtatct ttaacctcct tgttaacttt gtctcttcca gaatcgaagc   2880
 tgtaaaacta caaatggagc ccaagatgca gtccaagact aagatctacc gcagacccct   2940
 ggaccggcct gctagcccac gatctgatgt taatgacatc aaaggcaccc ctcctgagga   3000
 aatctcagct gcacaacctc tactacgccc caattcagca ggaagcagtt agagcggtcg   3060
 tcggccaacc tccccaacag cacttaggtt ttcctgttga gatgggggac tgagagacag   3120
 gactagctgg atttccttag gctgacctaa ggantcccta aagccttagc tggggaaggg   3180
 tggaccacat ccaccttttt aaaacacggg gggctttgca actttaggtt cacaccttga   3240
 ccaatcagag agctcactaa aatgcctaat taggcaaaga caggaggtaa agaaatagcc   3300
 aatcatctat tgcctgagag cacagcagga gggacaatga tcgggatata aacccaagtc   3360
 ttcgaagcgg caacggcaac cccctttggg tcccctccct ttgtatggga gctctgtttt   3420
 catgctattt cactctatta aatcttgcaa ctgcaaaaaa aaaa                    3464



      <210> 2132
      <211> 2296
      <212> DNA
      <213> Homo sapiens


      <400> 2132
 cgcaggcacg tgctaccacc acgcctggct aatttttagt ttttttacag aagcgggctt     60
 ttgccatgtt gtccaggctg gtctctactc ctgggctcaa gcagtcctcc tgcctcagtc    120
 tcccaaagtg ctggaattac aggggtgagt tgctgcgtct ggtgttggtg actttctaga    180
 gattactttt tggtttacat cattttcctt gtgactattt ttactttttt ggggggcggg    240
 gggacagtct tactcttttt agtttacatc attttccttg tgactattct atttttactt    300
 ttttaggggg cggggggaca tgagtctcac tcatgttggt caggctggtc tcaaactcct    360
 gacctcagtt gatccacgcc cttcggcctc ccaaagtgcc gggattacag gcgtgagcca    420
 ctttgcccgg cctgtatttt tacgttttaa taaatccccg tatttttgtt aaaggctggg    480
 taacctgact cctcccctca tttctactgc aaaataggag tacactgggg cctcccagtg    540
 gagctgttct ctgctgtttt aaattacttt ctactcctcc ctttctaacg tccactcctg    600
 gactcatttg ttagatcaat atatactggg actgttgtgt tttctttgag tgtactagat    660
 ctctttccag aagagcttcc cttgatccag atctccctaa ttgggaatga tgatttcaca    720
 gactagagtc tccgatgctg gtcatgatgt caaaactaag ttctgactca tttagggaac    780
 tggatacttg ggtctccaga agggccaatg ggagggccat aattctgttt attttcaaat    840
 tgtcttgttt tcaccttgtt agaatgaact ctggaagccc agccagggac aatgcacctt    900
 cacagagatt ctgcactaat ctgagtgaag gtctaaggtt tggaatctcc ccctcatgga    960
 gagaagcttt gtatggctgt catgcttaga cagtgattcc tgcaacttga ccttcaggct   1020
 gggagaggtg gagagccatg cctgttctcc ttccttgcta tggaatttgc tgacacaata   1080
 tcttccgcct ggtgctgggc atatcctaag aacttacaac tttcctgtat tatcctgtgt   1140
 gagcagctgt caccttattg ggggaaaaat gcctgaaaat tagggggcac ttcaagtaga   1200
 tagcttctat ttcctatatt tgtcttatat acaagtattt gcttttatca aaataattcc   1260
 aataaagcat tttaaagtaa agaataatat aggaaataga agctatcata cttgaagtgc   1320
 cccctaattt tcavtgavat tttcccccaa taaaggtgac agctgctcca cacaaggata   1380
 atacaggaaa gtttgtaagt tcttaggata tgcccagcac cagggcggaa gatattgtgt   1440
 cagcaaattc catagcaagg aaggagaaca ggcatggctc tccacctctc ccagcctgaa   1500
 ggtcaagttg caggaatcac tgtctaagca tgacagccat acaaagcttc tctccatgag   1560
 ggggagattc caaaccttag accttcactc agattagtgc agaatctctg tgaaggtgca   1620
 ttgtccctgg ctgggcttcc agagttcatt ctttactcaa ggataacacg gcgatgaacg   1680
 tcttacaact cagttgtttt gagtcagcag gggctgtggg gccgctagcc gagttccccc   1740
 tgccacgagc taggtcagtt ccaagcaaag acaccagaaa ctccagtgtg caacggtagt   1800
 tcacccaact gcactgggga ccgccctctc ctaccccagc caggccgcga cgtggccgcc   1860
 cgccggctgc tgcgcaaagg cagcgcaagc cgttgggatc ccctgctccc cctcactcaa   1920
 cagtcgggcc attacaactc tcatactgcc aacccacgag cccacttcgc aaccacactt   1980
 atccccacct tggctatcat cacccgatga ggcaaccagc cagaacgcct gaacgcaggc   2040
 acatacttcc tattctacac cctagtaggc tcccttcccc tactcatcgc actaatttac   2100
 actcacaaca ccctaggctc actaaacatt ctactactca ctctcactgc ccaagaacta   2160
 tcaaactcct cagcctccca agtagctggg actacaggca tgcaccacca cacctggcta   2220
 tttttgtatt tttactagat tttcaccatg tttactaggt ttcaccatgt tagccaggtt   2280
 ggtctcaaac tcctgg                                                   2296



      <210> 2133
      <211> 433
      <212> DNA
      <213> Homo sapiens


      <400> 2133
 cccacgcgtc cgaataactt gaccaacgga acaagttacc ctagggataa cagcgcaatc     60
 ctattctaga gtccatatca acaatagggt ttacgacctc gatgttggat caggacatcc    120
 cgatggtgca gccgctatta aaggttcgtt tgttcaacga ttaaagtcct acgtgatctg    180
 agttcagacc ggagtaatcc aggtcggttt ctatctactt caaattcctc cctaaaaaaa    240
 aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa    300
 aaaaaaaaga aaaaaaaaaa aaaaaaaaaa aaaaaggggg gggggggggt tataaaaaaa    360
 tttttggggg ggcccatttt tggggggggg ggaaaagaaa aatttttttt ttttgggggg    420
 gggtttataa acg                                                       433



      <210> 2134
      <211> 4341
      <212> DNA
      <213> Homo sapiens


      <400> 2134
 catggctacc tgggccctcc tgctccttgc agccatgctc ctgggcaacc caggtaaggc     60
 cttcccctcg ggatcgatcc tgatggccca cccagcctcg cactctcagg ctggctgaac    120
 ctggagcttg gactctgtgg gcacccaggt gcccctgcct ccccccggcc ttctcccccg    180
 tcatggaggc ctggccctcc cctcagagcc aggcttagtc cggtgtgctg cccagcctgt    240
 cactggcctg gccaaggagg agagacaggc cagggattct ggtcctaact ctactggcca    300
 cactgtgtgg cctgagaccc ccctttccct cccaagcccc tgcctccgca tctgcgtggt    360
 gaaggccatt ggccctcatc ggtggatctg cggttcctcg ggcctacact gtctaggatt    420
 gtgcggggct ggtgagagaa caagatctct tccgtgttca aggcagactt cctgccccct    480
 gcaccctgct ctctcccagg ccttgaggtc agtgtgagcc ccaagggcaa gaacacttct    540
 ggaagggaga gtggatttgg ctgggccatc tggatggaag gtaaaaaaag aaaatccctt    600
 gaaaggagat tgagggaagt ttctagacaa accgaccccc aaatctgtgt tgctggggga    660
 acagaggaga agagagagtc tcgccctcct ggctttctag aaggaacgtg agaacacgtg    720
 tttgtgctga gagtgggtca gagcggctcc agggcaaagc atgtggacag gtatcctggc    780
 cccctgcaag gcccagctcc tgtcctaggc cctggtcacc tcctggactc ccaccagcca    840
 ggagaacggg ctttccctct ccttccgcct gcggagggga agctgaagtc tggtcttcct    900
 caggtctggt cttctctcgt ctgagccctg agtactacga cctggcaaga gcccacctgc    960
 gtgatgagga gaaatcctgc ccgtgcctgg cccaggaggg cccccaggta cgtgttggct   1020
 ctctgctcac ctgccacagt ccctctcctt tccctcctcc ctggtggctc ctggggtgag   1080
 gtctggagct ctctaatggt caggaggtgg gagtggaggc tgggctgttt ctgacgatgc   1140
 tggttttgtt gaattcatgt ctggccagga gggctacagg tatctggcag actcctccag   1200
 gaggatcctc tggggtctca ccctccaagg agcctggggc tgcagaaccc aaataggcag   1260
 actcccctgg gagttcctca ataggagagg ggcaagtgca gggctgggaa agtactgggg   1320
 ttgtgggagg ctgtttctgg ggtgtctcag agcctctaag acaagcaaaa gggtgggtag   1380
 gggccaggca gccagttcag gccttcagtg tatccacgct ctgggaagag atcacggaca   1440
 ttcctgccgg cctcagaaac acaaagggcc cctttcctgg gcactttcac gcgctcccag   1500
 agtgtctgag agaccatcat aagggctttc tttcctgaca gggtgacctg ttgaccaaaa   1560
 cacaggagct gggccgtgac tacaggacct gtctgacgat agtccaaaaa ctgaagaaga   1620
 tggtggataa gcccacccag gtgaggccaa ggggctacag agcctcctgt ctgctgctca   1680
 atggaggggc cagcctgtga ccaggtcggg gatcggggag cccgggggca ccttgcacag   1740
 tgatcctggg ggagggcttc ctagaaggga atctgtgagt ccccgtgtgt ctgtggatga   1800
 atttcagaga acttgtgaaa ttgtgactct ctggaactgt gtaagtcaga cggcagagta   1860
 tacatggttt tcatcatgta tcctcaaaga gggcttgtcc cagagaagtt aggaatcttc   1920
 ccctaaagcc ctaacatttg tgtccaaggc agagtttgag aagctagttc cccaagaggc   1980
 ctgggtcagg actgataaat cccagatctg ctacttccaa gctgcatggc cttgggcaag   2040
 tcacttccac tttctgagcc cctgttatct tatctttgaa atgtgatgga taatagtccc   2100
 tatcttgcaa gttgtcaaac cctttttttt ttttttcctt gagataggat cttactctga   2160
 gacccaggct ggagtgcact ggtgtgatct tggctcactg caacctctgc ctccctggcc   2220
 caagcaattc tcctgtctaa gcctcctgag tacctggggc tccaggtgtg cgccaccatg   2280
 cccagctaat ttttgtactt ttgtagaaac agggtctcac tgtgttgccc aggctggtct   2340
 ccaacttctg agctgaagca atccacctgc cttggcctcc caaagtgtgg gattataggc   2400
 atgagccact gcacctggct gctgaagctt tttaaaagag ctgagggctg ggatgtgctt   2460
 agctccacgt ccagcactga gtaaatgctt aacgaatgac tgtgttacta ccaagaatta   2520
 ttgtttcact ctccctcctt ccctctcctc tgctgcccca aactactcag catcctggca   2580
 ctgcaggctc gcacttagcc ctggataccc agattcatcc tcctcccctg ggatggcata   2640
 gaagagactt taaaaccaaa tgagccaaga ctccaagctc tgaccacacc tcccaccccc   2700
 accagtcttc tctatgcacc ccctctatat ctggagcccc cagccaggtt ctggaccaag   2760
 gtagctacat ggcagagcat ttaatgtgtg cctggcagcc atgggcacca ttctccacac   2820
 agaaggcagg ggacaggtgc acaaggcgct gagaccccag cagggctaac tgtccttgtc   2880
 tcaggagccc tacctggcca gtcttgggcc aggccttggg gactgggagt aggggctgac   2940
 ccgtctgtac agtctctggc cccatggcac caggtgccag ctcctcgcac ccagtactcc   3000
 cattgctagg gctgctggaa cctgcagggt tggcagagct gggcaggact caccctataa   3060
 ccatgtccac tgtggtgctg ctgctgcaga gaagtgtttc caatgctgcg acccgggtgt   3120
 gtaggacggg gaggtcacga tggcgcgacg tctgcagaaa tttcatgagg aggtatcagt   3180
 ctagagttat ccagggcctc gtggccggag aaactgccca gcagatctgt gaggacctca   3240
 ggttgtgtat accttctaca ggtgagtgca gaggtgacag cagggatacc tcctgagggt   3300
 tggagacagc ttcccccagg atatatcaaa gctgcctcct tactccccca tctcccagca   3360
 tgggaaagtg tggagaattg agcagatgga ctttagctag aaatgtttga gaaatactga   3420
 ttagagcttg ggcttcagac acaggtggtt gtggagtaaa atctggtctc catctctccc   3480
 tggctgtgtg accttaagca aataacttga cctctctgag cttcagtttc ttcatctgtg   3540
 aaggagagat agcaatcctg atttttgaga ttggaatgag aattgaagga ggtcaccgtg   3600
 tgtgtggacc tgaccctggg gaaatgtcct cagactgagg ctattcaagg tcatcagacc   3660
 ctcagtcaaa ctccaatccc agcccagcac atggcccctg gggtcgggag ctggggccat   3720
 atcctccccc acaatcctgg gccctgagat ctgggctagg gaacccttca ggcaggggag   3780
 catgaggcct ttccctccat ggctgcccag gctgtgcctg gagagaacag atctcggctg   3840
 taggaaatgg ggccagaaag gggcctcggt gattggctct ggcagctcag ctggcacttg   3900
 ccaatagctc tgggatttta tgctggcaga tcgggggtcc ccaccatttc ctgtcattgg   3960
 agcttgtggc ttttctattc aaggccccac agcctgctca ggctgccgac tggcttccag   4020
 gatgtgcctc tgggtgtgtt cagtagggtc aggtggctct gggaccttaa gcaagtaaca   4080
 ttctgagtgc ctgcttctcc ttgaggaccc accacatctg cccacagcta gctgttctct   4140
 ccgctccagg tcccctctga gccctctcac cttgtcctgt ggaagaagca caggctcctg   4200
 tcctcagatc ccgggaacct cagcaacctc tgccggctcc tcgcttcctc gatccagaat   4260
 ccactctcca gtctccctcc cctgactccc tctgctgtcc tcccctctca cgagaataaa   4320
 gtgtcaagca agattttaaa a                                             4341



      <210> 2135
      <211> 958
      <212> DNA
      <213> Homo sapiens


      <400> 2135
 cccggaattt ccgggtcgac gatttcgtcg ctgagcttaa actgaagcaa gttcggtgga     60
 cgccggcggc gccctgatct aaagaaacga ctcagggact gcggcgcttg cacgtcaacg    120
 ggaggtgtga gcccaaaggt ctggacccag aaatgggacg tcggtcatca gatactgaag    180
 aagaaagcag aagcaagaga aaaaagaaac accgtagacg gtcctcctcg agcagttctt    240
 cagatagtag aacatacagc cgaaagaaag gaggaaggaa atcaagatca aagtcaagat    300
 cttggtccag agatcttcag cctcgttcac attcttatga tagaagacgc aggcatcgat    360
 caagcagtag ctcttcttat ggctccagaa ggaaacgaag tcgaagtcgt tcaaggggtc    420
 gagggaaatc ctatagagtt cagaggtcta ggtcaaaaag cagaacaaga aggtccaggt    480
 caagacctcg tctccgttct catagtcgta gcagtgaaag gtccagtcac agaagaacgc    540
 gtagtcggtc tcgggataga gaacgacgta agggcagaga taaagagaaa agagaaaagg    600
 agaaggataa agggaaggac aaggaattac ataacatcaa acgtggggaa tctggaaaca    660
 tcaaagctgg attagaacat ctgccaccag ctgaacaggc caaagccaga ctacagctgg    720
 ttcttgaagc tgctgcaaaa gctgatgaag cattgaaagc caaagaaaga aatgaggaag    780
 aagcaaagag aagaaaggag gaagaccaag ccaccctggt agaacaagta aaaagagtaa    840
 aagaaattga agctattgaa agtgattctt ttgttcagca gacattcaga tcaagtaaag    900
 aagtcaaaaa gtcagtggaa cctaatggag tgaaacaggc acctttaaca tcaggacg      958



      <210> 2136
      <211> 688
      <212> DNA
      <213> Homo sapiens


      <400> 2136
 ggcacgagag ggaaacgtca tatatctgga agttcagaaa ggccagttcc tgcggctcct     60
 ctgtgctgct gacagccagc cccctgccac gctgagctgg gtcctgcagg acagagtcct    120
 ctcctcgtcc cacccctggg gccccagaac cctggggctg gagctgcgtg ggatcctcca    180
 gagaacctga gagtgatggt ttcccaagca aacaggacag tcctggaaaa cctcgggaac    240
 ggcacatccc tcccggtcct ggagggccaa agcctgcgcc tggtctgtgt cacccacagc    300
 agccccccag ccaggctgag ctggacccgg tggggacaga ccgtgggccc ctcccagccc    360
 tcagaccccg gggtcctgga gctgccaccc attcaaatgg agcacgaagg agagttcacc    420
 tgccacgctc agcaccctct gggctcccag cacgtctctc tcagcctctc cgtgcactgg    480
 aagctggagc atgggggagg acttggcctg ggggctgccc tgggagctgg cgtcgctgcc    540
 ctgctcgctt tctgttcctg ccttgtcgtc ttcagggtga agatctgcag gaaggaagct    600
 cgcaagaggg cagcagctga gcaggacgtg ccctccaccc tgggacccat ctcccagggt    660
 caccagcatg aatgctcggc aggcagca                                       688



      <210> 2137
      <211> 393
      <212> DNA
      <213> Homo sapiens


      <400> 2137
 acataccata gagaagcctt atgaatgtaa ggaatgttta aagtcctttt tatatccctc     60
 aagactcact cgtcatcaga aaattcatac tggcaagaaa ccctttgaat gtaaggaatg    120
 tggaaaaacc tttatttgtg gctcagacct tactcgacat cacagaattc acactggtga    180
 gaaaccctat gaatgtaagg aatgtgggaa agcctttagt agtggttcaa acttcactcg    240
 acatcagaga attcacacag gtgagaagcc ttatgaatgc aaagaatgcg ggaaggcctt    300
 tagtagtggc tcaaacttta ttcaacatca gagaattcat actggggaaa aaccctatga    360
 atgtaaggaa tgtggcaatg cctttagtca gag                                 393



      <210> 2138
      <211> 454
      <212> DNA
      <213> Homo sapiens


      <400> 2138
 ggcggcgccc atggagctga tctgctggtc agggggctgg gggctgccgt cagtggacct     60
 ggacagcctg gccgtgctga cctatgccag atttactgga gctccactga aggtacacaa    120
 gatcatcaac ccctggtaga gcccttcagg aactctgcct gcccttcgga ccagtcatgg    180
 agaggtcatc tcagttccac acaagatcat tacccacctt ctaaaagaga agtacaatgc    240
 tgattatgat ctgtcagctc ggcaaggggc agacaccctg gccttcatgt ctctcctgga    300
 ggagaagttg ctcccggggc tggtacatac tttttggata gacaccaaga actacttgga    360
 agtgacccgg aagtggtatg cagaggctat gcccttttcc cttaacttct tcctgcctgg    420
 ccgcatgcaa cggcagtaca tgtaacggct accg                                454



      <210> 2139
      <211> 676
      <212> DNA
      <213> Homo sapiens


      <400> 2139
 tttttttttt ttgaagagag cagattctct ttattgagat acgggacaca gcgaagggtg     60
 gagagacgga acagcccccc agcctcagcc ctctccacgg gggccggatg ccagagatgg    120
 gagaagggat tcagtctctc gcccgggaaa cccagtccca cagagggcgc cggcaagggt    180
 gggacgcgac ctgggtgaca cggtgcaggg agtctttaaa tagaggaggg gctggagcgg    240
 ggaaacgcgc cggggcccta gcgcaccatg tattccttgc gcttattgag ccgaacttgg    300
 cagaaagaga agcctccgag gaggaggtaa aggcctgcag cgatgaaaca gttgtagctg    360
 acttgctcgt aaaggttgta tatgttctgg gggccattct caaaatcttt ctccgtgaag    420
 ggaacgtcct caatcaacac agcggaatgg acattgaaaa atattccgag cattatcaac    480
 atgatcactc cccaggcgct gaggacgatg ccgcaggcgg ccagcttcgg cccacagcac    540
 aggagcgacg ccataaagaa gggagtcggg gatcgccgag gtgcaagcgg gctcggaaag    600
 cggtgggaga aagcccagga tgccctcgcc cacgcgtccg cccacgcgtc cgcccacgcg    660
 tccgcccacg cgtccg                                                    676



      <210> 2140
      <211> 655
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> misc_feature
      <222> (1)...(655)
      <223> n = a,t,c or g


      <400> 2140
 gggcagcggc cgcgcaccac gccgccgggc gaataactgg attgaaattt ataatttcgt     60
 acagcaactt gcggagagat ttgtgagccc tgaaatgaga ttatctttca ttgtgttttc    120
 ttctcaagca actattattt tgccattaac tggagacaga ggcaaaatca gtaaaggctt    180
 ggaggattta aaacgtgtta gtccagtagg agagacatat atccatgaag gactaaagct    240
 agcgaatgaa caaattcaga aagcaggagg cttgaaaacc tccagtatca taattgctct    300
 gacagatggc aagttggacg gtctggtgcc atcatatgca gagaaagagg caaagatatc    360
 caggtcactt ggggctagtg tttattgtgt tggggtcctt gattttgaac aagcacagct    420
 tgaaagaatt gctgattcca aggagcaagt tttccctgtc aaaggtggat ttcaggctct    480
 taaaggaata attaattcta tactagctca gtcatgtact gaaatcctag aattgcagcc    540
 ctcaagtgtc tgtgtggggg aggaatttca gattgtctta aagtggaaca ggatnaatgc    600
 cggcccaggc ggaaaggcag ggtttttctg cacttacact gtaaatgaaa catat         655



      <210> 2141
      <211> 655
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> misc_feature
      <222> (1)...(655)
      <223> n = a,t,c or g


      <400> 2141
 gggcagcggc cgcgcaccac gccgccgggc gaataactgg attgaaattt ataatttcgt     60
 acagcaactt gcggagagat ttgtgagccc tgaaatgaga ttatctttca ttgtgttttc    120
 ttctcaagca actattattt tgccattaac tggagacaga ggcaaaatca gtaaaggctt    180
 ggaggattta aaacgtgtta gtccagtagg agagacatat atccatgaag gactaaagct    240
 agcgaatgaa caaattcaga aagcaggagg cttgaaaacc tccagtatca taattgctct    300
 gacagatggc aagttggacg gtctggtgcc atcatatgca gagaaagagg caaagatatc    360
 caggtcactt ggggctagtg tttattgtgt tggggtcctt gattttgaac aagcacagct    420
 tgaaagaatt gctgattcca aggagcaagt tttccctgtc aaaggtggat ttcaggctct    480
 taaaggaata attaattcta tactagctca gtcatgtact gaaatcctag aattgcagcc    540
 ctcaagtgtc tgtgtggggg aggaatttca gattgtctta aagtggaaca ggatnaatgc    600
 cggcccaggc ggaaaggcag ggtttttctg cacttacact gtaaatgaaa catat         655



      <210> 2142
      <211> 2218
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> misc_feature
      <222> (1)...(2218)
      <223> n = a,t,c or g


      <400> 2142
 tttttttttt ttccacggaa acagccgttt ttattccaca aacagtaaac tccatccact     60
 acacagtgac atacactgtg tagcacaccc catcaccttg gccagtgctg ccagccgacc    120
 tttctgtggt gatggaaatc tttttctgtg ctgtccaata cagcagccac cgaccacttt    180
 tgcttattga gcacctcaat atagaggtgg ccactacagg tgaggaaatg aatttctaag    240
 ttaattcaaa ttcaaatgcc acatttggct cgtggctcct gtactggaca acacagctgt    300
 aggccctgac ctggtccagg gcactttggt tcaaaagcca actctgagga gagcaagtgg    360
 cagaaacagc ccttgggctc ccctccccag agagaaacgg cagctgcagc tgctggaaag    420
 ggcaagaatc agagtggggg gacacctcgg gcgcgccgga taaggttggc cagccgcttg    480
 gccaggccac ctgtgcgggg ctcctcgatg tggaaggttc gggtgaggag attgtagaag    540
 gagccgtagc acacggccac cacagtgcac gtgaggcaga tcacgttgta gggcatgctg    600
 aagtccggtg tcggcaggtt caccagcagc ggctccgtgt agagccgcac aaagtagtta    660
 gagccatcag agactgggaa caggctgttg aagaggggac tctcttccca gtccactggc    720
 ttggctgcta ccatgctggg cacaagggcg ctgaggacag atgggctgac atagaagcca    780
 tggttaggat ctggcgtgta ctcggtccac ttcagcagcg cccgctcaaa ctggatggaa    840
 accttggtga ctgagttggc cggcagctga atcagcatct ccaggaggtg gggttgcagc    900
 cggtcctggg caggctggta gtggatgtaa cttggtttgt tctccttgcc cttggaggtg    960
 atggtgaggg tgtgcacata cagccgcaga taccagggta cggtgtccag cagcagcacc   1020
 gggaaggccc ggtatgggtg ggtgttgtac agcagtgtgc tcagctcccc cttctgcagc   1080
 ccatagccac tcacgtaccg ctgggcatgc aggaagggca ctgggggggc ctcattctct   1140
 gggggtctct tccacttgag ctggatgttg aggtttcgag agttgttgat catggcggtg   1200
 tcaagcaagt catagatggc ataggtcttc cgagtgccta ggatgacgtc ctgatatgta   1260
 gtggtcgggg gtgggtgcac ctctaatgtc tcgttgtcct ggggacacaa aggcagggct   1320
 ggttgtaggt ggtgatgtcc acatagactc ggctctctga agccaggggg cagggctccg   1380
 tgagggttcg ggagaacatc cggaagaggg accagtcttt ctttccctgc cccgtgatga   1440
 aggcatcaaa tacaactgac agggtctgcc tcagctccca ggagatgcta gtacagcgtg   1500
 catttctgca aacagggcgg atatgcactg cctgggagtg gtagctggtg tggaacaagc   1560
 gatctgcctt cagcagcaca gagaggcctg ccttggaact acagggcaag agcttcttcc   1620
 agggggtgag gttttcggtg cagaccacct cccgcggcag cacagcatag cgcagaaagt   1680
 agtggtcagt gtcattggcc agacccaggg gtttgaagga ggcagtggga gtgactgtgt   1740
 tggtggagtc gatgaagttg agagaggcgc agaagatccc tgagaggaca ttactgagct   1800
 ccttccaaga tttatccaca tcagtgacag tgtcttggaa ccagacccac agctctgcac   1860
 ctgatggggc ctgcaggaag ggtggccccc agtatcgggt cctccaaaag ccttgtgtga   1920
 atgacaggtg cagctcccgt agagaatact tggagatcag ctgccccagg gctttgggaa   1980
 agagcctgta atgggacact ccttcccgct gaagctccga atcccagcgc gtgcggaact   2040
 ggaatgtggc ggctacgtcc ccggaaggca gcggggtgat gacaagttcc tcccgcaggc   2100
 tgtcgcgtgg gggttctgca aggcaccagc cgccgggccc caggagcaac aggacgagca   2160
 gagcaagcgg catagccgcc cccatgcccg nacgcgtggg cggacgcgtg ggtcgacc     2218



      <210> 2143
      <211> 669
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> misc_feature
      <222> (1)...(669)
      <223> n = a,t,c or g


      <400> 2143
 gattacgcca agcttggcac gaggggcagc gcctggcccg ggcgcgcaaa gctgctcttc     60
 tcgcactcgg ggctctggcg catctgcgaa gtgctgcacc gtgcagtcat tgtggtcctg    120
 cccctgagcc tggtccttct cgtgtgtggc tggatctgcg gcctgctcag ctccctggcc    180
 cagagcgtgt ctctgctgct tttcaccggc tgctacttcc tgctggggag tgtcctgaca    240
 ctggcggggg tcagcatcta catcagctac tcgcacctgg cctttgcgga gacggtgcag    300
 cagtatggcc cgcagcacat gcagggcgtc cgcgtcagct tcggctgggc catgggcctg    360
 gcctggggct cctgtgcctt ggaggcattc agcggaaccc tcctgctctc agctgcctgg    420
 accctcagcc tgagcccccc aatctgtggt catctgagtc cccagcaggt gggagggaga    480
 gggggagact gaggcccaga gcggcagagg gacccaccca gatcgcctgg cgccagagag    540
 atgccgtctc aggccaaggc ctccctggcc tctgttctgt ccactctccc cgaagggcag    600
 gcttggtgga gaagaggctg atgagagggc ccgagagccc cttcgatttg cannnnnnnn    660
 nnncaaggg                                                            669



      <210> 2144
      <211> 669
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> misc_feature
      <222> (1)...(669)
      <223> n = a,t,c or g


      <400> 2144
 gattacgcca agcttggcac gaggggcagc gcctggcccg ggcgcgcaaa gctgctcttc     60
 tcgcactcgg ggctctggcg catctgcgaa gtgctgcacc gtgcagtcat tgtggtcctg    120
 cccctgagcc tggtccttct cgtgtgtggc tggatctgcg gcctgctcag ctccctggcc    180
 cagagcgtgt ctctgctgct tttcaccggc tgctacttcc tgctggggag tgtcctgaca    240
 ctggcggggg tcagcatcta catcagctac tcgcacctgg cctttgcgga gacggtgcag    300
 cagtatggcc cgcagcacat gcagggcgtc cgcgtcagct tcggctgggc catgggcctg    360
 gcctggggct cctgtgcctt ggaggcattc agcggaaccc tcctgctctc agctgcctgg    420
 accctcagcc tgagcccccc aatctgtggt catctgagtc cccagcaggt gggagggaga    480
 gggggagact gaggcccaga gcggcagagg gacccaccca gatcgcctgg cgccagagag    540
 atgccgtctc aggccaaggc ctccctggcc tctgttctgt ccactctccc cgaagggcag    600
 gcttggtgga gaagaggctg atgagagggc ccgagagccc cttcgatttg cannnnnnnn    660
 nnncaaggg                                                            669



      <210> 2145
      <211> 1293
      <212> DNA
      <213> Homo sapiens


      <400> 2145
 ggctttggga ggggagccct gatccgcctg aatatctggc cggcggttca aggggcctgc     60
 aaacagctgg aggtctgtga gcactgcgtg gagggagaca gagcgcgcaa tctctccagc    120
 tgcatgtggg agcagtgccg gccagaggag ccaggacact gtgtggccca atctgaggtg    180
 gtcaaggaag gttgctccat ctacaaccgc tcagaggcat gtccagctgc tcaccaccac    240
 cccacctatg aaccgaagac agtcacaaca gggagccccc cagtccctga ggcccacagc    300
 cctggatttg acggggccag ctttatcgga ggtgtcgtgc tggtgttgag cctacaggcg    360
 gtggctttct ttgtgctgca cttcctcaag gccaaggaca gcacctacca gacgctgtga    420
 gtacctggcc agcagcaagt acctgagtcc cagctcacct cctggttcct gccccaccgt    480
 tccccttcag tacccagggt gctgtcttct ccatgggcaa gccctcagga cggtgacagc    540
 gtgctccatg tgagccacac cccttttgtc tcctccagtt ggggtgtttc ctttgtcaga    600
 tgttggctgg gaccaggact cagcctgggc cagtctagga gcccagctga gccctcctgt    660
 gtcttttccc ttcatgctgc cagcagggaa gagaaccagt aggtgccagc ccaggcaagc    720
 ctgtggcccg cgtttctgtg gctgtgggca ggagctgggc cttgtgtcta gttgggtttt    780
 gctctgagaa ggggagctgt gcctgaggcc ctctgtgtgc cgtgtgtgct gtggggcggg    840
 tcgccacagc ctgtgttaaa gtgtttgctc ttcctctgct gcctcctctc gaggcagggg    900
 gtccttggct ggctgaggca gtgtcacctt cctgagtgtc ctctttggcc tctgcagaat    960
 ctgacccctt tgggcctgga ctccatcctg aggggaaagg aggatgcaga gggtggcctc   1020
 tgggcaccct tgtgggtaag cggggggcgg gggcgggaaa aactctggcc gccagttttt   1080
 ggctcctgcg ggcaccaagc aggccaagtg tttaatgcct gacatctcct cctgtcctgg   1140
 gcctggaacc tgcagctgag aaaatccctc aaccacctcg tctcctccat cgcccctgct   1200
 gggcccccca gccctgacag tgggttgtat gcctgcctct ttccaccaac tggcctgggc   1260
 actgccccca aataaaggaa ctctgcactg caa                                1293



      <210> 2146
      <211> 2207
      <212> DNA
      <213> Homo sapiens


      <400> 2146
 tttttttttt ttcaaggaaa tcaaatcttc aatgaatgaa aaactcagtg ccatctgggg     60
 ccagggggtc accggaccag gtggaaagtc agccagtata tgatgagggg ctggaaggct    120
 gcagctccca gagtcaggta gagctggaga cgctgccggg ggacggggcc ccccatgctg    180
 tcggggccca gggctgctgt ccgcaaagag cgcacaatga agtacatgag cgccgatgag    240
 gtccaggcca gcgccacgta gtagccatcg ctgccgaaca gcagccccgt gagcacactg    300
 aggatcattc ccacgtattt gtagccactg taggccagca ggtgaaaggt gctcaggtca    360
 ctgcgcacgg tggccaggta gaggcccagg agcagggcca gcacctccat caccacccac    420
 accagcgctg tgcttgcaca caggcccagc acctccgggg agaacctttt ctgaatgccc    480
 agtgccatcc cagccaggag cacgtaagta atgaaggcca tcgtggggat atagaggtca    540
 ggggcgttga ggtcttgccg ggggggcaga ggagcatcac gactgtactg cacttcccag    600
 ttctggtgtg tgtaggggaa gaccagcagc cctagcttct tggccacgta ggctgtgtcc    660
 acagcaaaaa aatacttgag tttgctcaca gacacaaaac ggtgcagctc cttgtgcacc    720
 atgtccttcc catgggatgc gatggagctg ccataggcca tagccacatt ggccattggg    780
 tccccaagca agtggttgac actgaaggcc acgtctgctc ctgtggctgg gtatcccccg    840
 ggctggctgg aataaccacc gcttgtgtca tcgaagaggg gagggggatc cggggctgcc    900
 cgggccctgt gcttggagcc gtgggctccg tagcccgagt gataagccat ggccgcgacg    960
 ctcgctgtcc ccgagggccc gctgcgccgc ctcgtgggta cgaatactaa tgaggcagct   1020
 gctccgcgcc cagggtaccg accgaggcca cccggccgcg cgacacgtcc cccaccccgc   1080
 cggtctcggc caccatgtcc gtggcgtcat cccccgcgcc tgccattggc tcttcggcgg   1140
 cgccggctcg cccctcccct ctcccaattg gccactgacg agctctggcc tgagcggatt   1200
 cggcagaagg caacatccgg gtgagggaca ggcggagcga cttgcggtgc ctgggattgg   1260
 atcacgggct tgccagttca cggtgggaac agccaataga agagttaaga aagaaggtgg   1320
 gcgagaatta tttgcgcgcc tgcgcggtga ggcacttgac gcaccctgcc acgactacac   1380
 cagggagtcg agaggtaacc tgcagccgga gtcaggagca aagcttcctt ggtgggacgt   1440
 actccaggag ggaacggggc ggtcgagttc caaccaagcc ctgcccttcg gggcgcctgt   1500
 ttctccctct ctgggcttgt tttcctcccc cgtcacctac acttcaccca atcttggaac   1560
 ggagccccgg cagacccgga ggtggtggtg ggaggccgga cctatcagtg acagagctgc   1620
 caagcaagcc ccaggatgct gactccaccc gcctcccact cctcttctcc gcgcgggtgc   1680
 tgtccgtcgt ccggtgctga aaatgtcctc ccgcctcagc cgccatcctg tagactcccg   1740
 ggggcctgcg tatgggaaag ttttggggtc tcgaaccaca cgctcctagc gagcgcgtgg   1800
 ccgcacgcac acatacacgc atactgcaaa actggggccc agaggatccg aagtctgaga   1860
 gattgggtgg tataggtggg gcaggatcct gccccgggcc tgtcccatag actctcccgt   1920
 agtccagcag atttgggggc agaggtgtgc tgatttgcgt cctgaagctg cagcctaaac   1980
 tcctgagtca tcgccgggcc tgtggtcttc ttgaagtgag gcccctaagc ctcacttgta   2040
 gtcccggggg ttcctttctc tccacccagg ttctgatcac tcccaacccc gcggagacag   2100
 tcttcagggg cctccctctc acagaccttc agccaccgct ttctagagag catgagcagg   2160
 ttctctgcga cctctctaat tagctaccag gtatccagtt acaccag                 2207



      <210> 2147
      <211> 1380
      <212> DNA
      <213> Homo sapiens


      <400> 2147
 atgggctcca ggctgctctg ttgggtgctg ctttgtctcc tgggagcagg cccagtaaag     60
 gctggagtca cacaaactcc aaagcacctg atcacagcaa ctggacagca agtgacgctg    120
 agatgctccc ctaggtctgg agacctctct gtgtcctggt accaacagag cctggaccag    180
 ggcctccagt tcctcattca gtattataat ggagaagaga gagcaaaagg aaacattctt    240
 gaacgattct ccgcacaaca gttccctgac ttgcactctg aactaaacct gagctctctg    300
 gagctggggg actcagcttt gtatttctgt gccagcagcg tcaaagtagg caccggggag    360
 ctgttttttg gagaaggctc taggctgacc gtactggagg acctgaaaaa cgtgttccca    420
 cccgaggtcg ctgtgtttga gccatcagaa gcagagatct cccacaccca aaaggccaca    480
 ctggtatgcc tggccacagg cttctacccc gaccacgtgg agctgagctg gtgggtgaat    540
 gggaaggagg tgcacagtgg ggtcagcaca gacccgcagc ccctcaagga gcagcccgcc    600
 ctcaatgact ccagatactg cctgagcagc cgcctgaggg tctcggccac cttctggcag    660
 aacccccgca accacttccg ctgtcaagtc cagttctacg ggctctcgga gaatgacgag    720
 tggacccagg atagggccaa acctgtcacc cagatcgtca gcgccgaggc ctggggtaga    780
 gcagactgtg gcttcacctc cgagtcttac cagcaagggg tcctgtctgc caccatcctc    840
 tatgagatct tgctagggaa ggccaccttg tatgccgtgc tggtcagtgc cctcgtgctg    900
 atggccatgg tcaagagaaa ggattccaga ggctagctcc aaaaccatcc caggtcattc    960
 ttcatcctca cccaggattc tcctgtacct gctcccaatc tgtgttccta aaagtgattc   1020
 tcactctgct tctcatctcc tacttacatg aatacttctc tcttttttct gtttccctga   1080
 agattgagct cccaaccccc aagtacgaaa taggctaaac caataaaaaa ttgtgtgttg   1140
 ggcctggttg catttcagga gtgtctgtgg agttctgctc atcactgacc tatcttctga   1200
 tttagggaaa gcagcattcc cttggacatc tgaagtgaca gccctctttc tctccaccca   1260
 atgctgcttt ctcctgttca tcctgatgga agtcctcaaa caccatttcc atacccaggc   1320
 attctgggtc cccactggag ggttagtctg aagggcaatg gctgggcttt ggaaaaccag   1380



      <210> 2148
      <211> 393
      <212> DNA
      <213> Homo sapiens


      <400> 2148
 cgagattgga gcagaaactg gagcaagaag tgggcctggg gctgaagtag agaccaaggc     60
 cactgctata gccatacaca gagccaactc tcaggccaag gcaatggttg gggcagagcc    120
 agagactcaa tctgagtcca aagtggtggc tggaacactg gtcatgacag aggcagtgac    180
 tctgactgag gtcaaggcca aagccaggga agtggccatg aaagaagcag tgacccaaac    240
 tgatgctgag gctggcaaaa tagttaagaa agaagcagtg acacagacca aggctaaagc    300
 ttgggcgctg gttgccaaga cagaggccaa gagagaagca atgacccaga ccaaagctga    360
 aactcatata ttggctgaaa aagagactgt att                                 393



      <210> 2149
      <211> 3261
      <212> DNA
      <213> Homo sapiens


      <400> 2149
 tttttttttt ttttttgata tttaaaaaat cattttactt attaaaactt tctcatttcc     60
 caaggcactt cagtagcttt cacaaaaaca tgtttgttct tttttaacca ggtgaggcat    120
 atgctttaag gagtaccatg gtaacataat cagcaaagag aagacaatta cactgaacac    180
 aaaatatcac ccaataaagt tacagggact aaagtgaggc tactctgaaa gactatgaac    240
 acaatttaaa ttggggtttt gtaatatcct ccccatgact aagtatcaaa aaaggaacac    300
 acacaatgac cctgtttttg gcacttagag aaagtgctag aggcttaggg ctggtaaggc    360
 cttgcaccca gtggcagctg cagacaattg ccagagtgat tctgtgttta aaaaaaaaaa    420
 aaaaaaaaga cacaaaccag gaggctaagg aaccagcctt tcccaagtgc attctgaagg    480
 gcaaataaca aggagaaaag gatacaacaa caaacaaata aacagtaaaa caaaacccac    540
 attacagctt tgagagaaaa gacaacgttg ctcatctctc tcacctgata aatttccttt    600
 aaaccataca taagacgcta tagtagcaag gaggtttcca cagcagtgga aaacaagaat    660
 agtagattca atggagcatt tattatgagc ctggacaagc ccagtgcttt gatcagatgt    720
 aaacaagtct actcagtcgt catgctgagt ggtcttaaga gctcacacat cagtgcactt    780
 tgctggtgat ctgcatctgc tcattctgct ccatcttcat tacctttcac tttccctagc    840
 tctgcgctct cctgccctgg ggaagcaatg atccagttaa tgtcctctgt aactgagaaa    900
 aggtaagaat caaactcctt gtgcaattac ttccttttcc tctaaagttc accactagag    960
 gggagtgggg aaaggggtgg gggacttaga cctctagcct tattaggggc cttttcaagt   1020
 agtctaaaat taaaatgtac atttagcata tgcttctcac attcctccag atctcactgg   1080
 ttctagtgaa aaattaactg ctttggaggt gctgagtcca tcattgtaat agttaggact   1140
 tagatgaagt tgtctgtagg tagccccagt gtccctagag gaaggtggtg ctctagggcc   1200
 atatgtagcc tctgagtgtg ggtgcccatc caggagcaag tcagacacag gtcaagagga   1260
 caaacagcaa aggcctttgt cactgaagga ctcggagtct gcacaagctg gccatttctg   1320
 gcaagacagt ctttcctctt cagtttctcc cttactggaa gcgatgttag aaggctgtgc   1380
 ttttaaggat tgtgggcctt tcttgaccat cttttaacat ccttgtgtga cttggagttt   1440
 ttctgtgttt cattcctttg actcttagca tctggtcaat ggtgtctggg agtggggtac   1500
 cgaagctctc tgggagaaac aaggtgagga tggctgtcag gatggtcaga cttcccatga   1560
 gaatgtaggg caggaagcgg tcgtaggcac caaggtaaac gaagtaggga gacaggatgc   1620
 tgcccaggcg ggatgctgtg gagctgactc ccacacccat gtttctcacc actgtgggat   1680
 acagctcggc tgtgtacacg tagaccatgg aaaaggcagc cgtgactcca aacttgccca   1740
 ccatcaccag gactgtagcc aaataataca agtctggggg taccagctgc atgaagagaa   1800
 ggacactgcc acccaggaag agggcagtgg ccatggaata gcgccggggc aaatattgca   1860
 gcagcagcca ggccaacaca tatgctggga cttcaaccat cgctgaaagg aagcagttca   1920
 caaagatgtc cccatgcaag ttaggagtat caagcgaaag cccaaaatag cccactgata   1980
 tggtcatcca cagcattatg gacatgatgg tgaccatccg gatattccag gttcgaagca   2040
 gatccagaat gttgtgggac tgctgcttct tggaacttag gtcttgtaac tcactcgggt   2100
 caaagatagt ggaaggcaca acaatcccat tggctttggc agccttgcgg atgatcacct   2160
 ctgcctcttc aaatcgtccc tgagagatga gccatcgggg ggactcaggg atgaaccacc   2220
 agagtgccac gcacagcacc cccggcatcg tcagcgccac cagcagcatc cgccagtctc   2280
 ggatgaagta agcaaacagt ggcagcacca tgtagccaaa tgcataaaat atgcacactc   2340
 ctaacgtaga gaatattata cgaactgact tgccaagaat ttctgtcccc aggacaaatg   2400
 ctgccacata gttggagatc tggcccatgc ctacaaggac aaacagcacg acaaacatct   2460
 caaaattctt cgagaagatc tgcaggaagc tgaagcctgt ctgcatgccc atggtcacga   2520
 acagcacatt cttccggcca aacctgtctg acagctgccc tgaaatgaag gagcccaaca   2580
 gcacacccac gaagaacaag gagattgtga gtggggcctt ccagtcgtcc tcacacacca   2640
 ggttccactc ggtcacaatg gtggacaggt agacgtcctg actgaactcc cagccatcca   2700
 gacagctctc ctgctccagc tgccccaggt ccacgtcgcg ccccggctcc agcccgagcg   2760
 ccgagaagtt ggcgatggtg gcgagccggt agcggcggca gctgtggggc acctcgcggc   2820
 cgtcccgcag ccgcagtggg acagtgtggt tgcgccaggc gctgctcagg ttcgcggcgt   2880
 ccggcacccg gcagcggtgc tccggggtcg ctatcaggaa cacggaggac aggccggtga   2940
 agccattggg gatgatgctg gcgctgagca ggaagaagat gaggcgctgg aagggccccc   3000
 actcgcccag gaaggcggtc acctcgtcgt agtcccgcat gccgccctca gaggcccaca   3060
 gagcgcggcc tggggtctgg gaacgcggcg ggctttgcgc gtgcgcgcgg ggcacccgcc   3120
 gccgaccagg caagccaggc agcaggcgac ccaagaccgt ccgcggaggg taggctcgcg   3180
 agctgacacc gccgccttgg tcctgccgcg gctggcctta catatggcgc acgaccaggg   3240
 aaggttccgg gcctgggccg c                                             3261



      <210> 2150
      <211> 1284
      <212> DNA
      <213> Homo sapiens


      <400> 2150
 atgaacatga acatcaaaaa aattgtaaaa caagccacag ttctgacttt tacgactgca     60
 cttctggcag gaggagcgac tcaagccttc gcgaaagaaa ataaccaaaa agcatacaaa    120
 gaaacgtacg gcgtctctca tattacacgc catgatatgc tgcagatccc taaacagcag    180
 caaaacgaaa aataccaagt gcctcaattc gatcaatcaa cgattaaaaa tattgagtct    240
 gcaaaaggac ttgatgtgtg ggacagctgg ccgctgcaaa acgctgacgg aacagtagct    300
 gaatacaacg gctatcacgt tgtgtttgct cttgcgggaa gcccgaaaga cgctgatgac    360
 acatcaatct acatgtttta tcaaaaggtc ggcgacaact caatcgacag ctggaaaaac    420
 gcgggccgtg tctttaaaga cagcgataag accccactca atcgacgctg gaaaaacgcg    480
 ggccgtgtct ttaaagacag cgataagttc gacgccaacg atccgatcct gaaagatcag    540
 acgcaagaat ggtccggttc tgcaaccttt acatctgacg gaaaaatccg tttattctac    600
 actgactatt ccggtaaaca ttacggcaaa caaagcctga caacagcgca ggtaaatgtg    660
 tcaaaatctg atgacacact caaaatcaac ggagtggaag atcacaaaac gatttttgac    720
 ggagacggaa aaacatatca gaacgttcag cagtttatcg atgaaggcaa ttatacatcc    780
 ggcgacaacc atacgctgag agaccctcac tacgttgaag acaaaggcca taaatacctt    840
 gtattcgaag ccaacacggg aacagaaaac ggataccaag gcgaagaatc tttatttaac    900
 aaagcgtact acggcggcgg cacgaacttc ttccgtaaag aaagccagaa gcttcagcag    960
 agcgctaaaa aacgcgatgc tgagttagcg aacggcgccc tcggtatcat agagttaaat   1020
 aatgattaca cattgaaaaa agtaatgaag ccgctgatca cttcaaacac gttgcatgcc   1080
 acagataaag ataagcgtgc acctgccact gcaataaccc atggtttccg agacccctgc   1140
 cacagccaga ctgtcccacg tcggccaccg tcgagccccc actttatcca atcagatcgc   1200
 ggggaaggac acgcaaacct gccgagggct cgagggctcc gggctgctgc tgctgccagc   1260
 gtcctgggaa gtgacaggca ttag                                          1284



      <210> 2151
      <211> 2898
      <212> DNA
      <213> Homo sapiens


      <400> 2151
 agcacacctt ccacagcact ggtctctcct ctcagaactg tgtttcccac acaggctcac     60
 gggctcccaa ggggatacgg ctgcttgcgg tgactgagct ccctcctcac agcagagctg    120
 aggtctgggc tccaggtccc cagtggagtc cctcgcagac agaaatagcc gagaccatac    180
 aaccaaccaa atacacccct aacaagctta agcgacaaat actcaaaaac ataaaaccca    240
 gtaaagagga aacaccacca cctacacaga caccaaacga cggccacttc cagttttcct    300
 gtgaagtctc tgtgatgctc ccctggagca gctgcagcac ggagagaaca atccgccgga    360
 cagctcgcaa accccgacag cgcataaacc gcatcctggg ctcgtggtca aaacatcctg    420
 tagcaaggag ggtcaatgct tacatgatga agatgatgca gaaggacagg aaggccaggg    480
 ctgtggctcc agctcccccg actgctgcca gtgtcacttg tgatacagac ctgccccccg    540
 gggccccaca gtgctcagtt gaagggggtc ccggggaccg cagcctccgc ttccgctgct    600
 cgtggcccgg cggggcccct gctgcctccc tgcagttcca gggtctcccc gaaggcatcc    660
 gcgccgggcc agtgtcctct gtgctgctgg cggccgtccc cgcccacccc cggctcagcg    720
 gcgtccccat cacctgcctt gctcgccacc tggtggccac gcgtacctgc acagtcacgc    780
 cggggaggcc cctggctcca ggaggcggga gtcgcctgcg gctcagtcaa gatgggcgga    840
 aactccacat cggcaacttc agcctggatt gggacctggg aaattactcc gtgctgtgca    900
 gtgggccgat gggtgctggc ggtgaccaga tcacctgcat tgtgagaagg gtctctagag    960
 tgcgattgca gcactattct tgcgccgaaa agagtcttga gacctcagtt tctgagagaa   1020
 gaaccctgag gaacagacgt tccctggcgg ccctggcgcc ttcaaaccca gacatgctgc   1080
 tgctgctgct gctgctgccc ctgctctggg ggacaaaggg gatggaggga gacagacaat   1140
 atggggatgg ttacttgctg caagtgcagg agctggtgac ggtgcaggag ggcctgtgtg   1200
 tccatgtgcc ctgctccttc tcctaccccc aggatggctg gactgactct gacccagttc   1260
 atggctactg gttccgggca ggagacagac cataccaaga cgctccagtg gccacaaaca   1320
 acccagacag agaagtgcag gcagagaccc agggccgatt ccaactcctt ggggacattt   1380
 ggagcaacga ctgctccctg agcatcagag acgccaggaa gagggataag gggtcatatt   1440
 tctttcggct agagagagga agcatgaaat ggagttacaa atcacagttg aattacaaaa   1500
 ctaagcagct gtctgtgttt gtgacagacc ctccttggaa cttgaccatg actgtcttcc   1560
 aaggagatgc cacagcatcc acagccctgg gaaatggctc atctctttca gtccttgagg   1620
 gccagtctct gcgcctggtc tgtgctgtca acagcaatcc ccctgccagg ctgagctgga   1680
 cccgggggag cctgaccctg tgcccctcac ggtcctcaaa ccctgggctg ctggagctgc   1740
 ctcgagtgca cgtgagggat gaaggggaat tcacctgccg agctcagaac gctcagggct   1800
 cccagcacat ttccctgagc ctctccctgc agaatgaggg cacaggcacc tcaagacctg   1860
 tatcacaagt gacactggca gcagtcgggg gagctggagc cacagccctg gccttcctgt   1920
 ccttctgcat catcttcatc atagtgaggt cctgcaggaa gaaatcggca aggccagcag   1980
 cgggcgtggg ggatacaggc atggaagatg caaaggccat caggggctcg gcctctcagg   2040
 gacccctgac tgaatcctgg aaagatggca accccctgaa gaagcctccc ccagctgttg   2100
 ccccctcgtc aggggaggaa ggagagctcc attatgcaac cctcagcttc cataaagtga   2160
 agcctcagga cccgcaggga caggaggcca ctgacagtga atactcggag atcaagatcc   2220
 acaagcgaga aactgcagag actcaggcct gtttgaggaa tcacaacccc tccagcaaag   2280
 aagtcagagg ctgattctca cagaacaaga accctctaga gccccatgct atgcagtagg   2340
 tcaccagggc tccctcctcc tgtctaacca aaacttggac caatgtctcc cctttccccg   2400
 gctaccaggg acccatccct gcctctagct tctactaccc accattctcc tctcgacctc   2460
 tctgaggttg actattttag attccacata gagatgaggt catgtggtac ttgcctctct   2520
 gtgtgtggct cattttacac aaaaaaatat cccctaggtt catccatgtt ctctcaaatg   2580
 acagaatcaa gcactgaata tttttttttc tttgagagat ggagtttcgc tctgttgccc   2640
 aggctggagt gcagtggttc aatctctgct cactgcaacc tccacctcct gggttcaaac   2700
 gattctcctg cctcagcttc ccaagtagct ggtactacag gcgtgtgtca ccacgcccag   2760
 ctaatttttg tattttttag tagagacggg gtttcactat aagtgggcca ggctagtctc   2820
 aaactcctga cctcaagtga tctgcctgcc ttggcctccc aaagtgctgg gatttcaggc   2880
 atgagccacc gcacccag                                                 2898



      <210> 2152
      <211> 646
      <212> DNA
      <213> Homo sapiens


      <400> 2152
 gcgagccctg gacctctctg tgcagtatcc tccagagaac ctgagagtga tggtttccca     60
 agcaaacagg acagtcctgg aaaaccttgg gaacggcacg tctctcccag tactggaggg    120
 ccaaagcctg tgcctggtct gtgtcacaca cagcagcccc ccagccaggc tgagctggac    180
 ccagagggga caggttctga gcccctccca gccctcagac cccggggtcc tggagctgcc    240
 tcgggttcaa gtggagcacg aaggagagtt cacctgccac gctcggcacc cactgggctc    300
 ccagcacgtc tctctcagcc tctccgtgca ctataagaag ggactcatct caacggcatt    360
 ctccaacgga gcgtttctgg gaatcggcat cacggctctt cttttcctct gcctggccct    420
 gatcatcatg aagattctac cgaagagacg gactcagaca gaaaccccga ggcccaggtt    480
 ctcccggcac agcacgatcc tggattacat caatgtggtc ccgacggctg gccccctggc    540
 tcagaagcgg aatcagaaag ccacaccaaa cagtcctcgg acccctcttc caccaggtgc    600
 tccctcccca gaatcaaaga agaaccagaa aaagcagtat cagttg                   646



      <210> 2153
      <211> 449
      <212> DNA
      <213> Homo sapiens


      <400> 2153
 cagtgtggtg gaattcacgg tctgccacac cagggggcca tagtgccgac aggggagcag     60
 cctggggtgg cagcccaagg ccagctgctg tttgttttcc tctgatcctt gtggaaggcc    120
 caaaaggatc ttttgtgact ggcctaaaat ctgccaggct ggactgtgct gttcctctct    180
 gtcctggggc tcctggcctc ccgggctgtg tccgcactca gcagcctctt cgcggccgag    240
 gtcttcccca cggtgatcag gggggccggg ctgggcctgg tgctgggggc cgggttcctg    300
 ggccaggcag ccggccccct ggacaccctg cacggccggc agggcttctt cctgcaacaa    360
 gtcgtcttcg cctcccttgc tgtccttgcc ctgctgtgtg tcctgctgct gcctgagagc    420
 cgaagccggg ggctgcccca gtcactgca                                      449



      <210> 2154
      <211> 732
      <212> DNA
      <213> Homo sapiens


      <400> 2154
 ggcttcggcg ctgcccgtgt gcggagcctc tttaaggaag cccgagcccg ggccccctgc     60
 atcgtctaca tcgatgagat cgacgcggtg ggcaagaagc gctccaccac catgtccggc    120
 ttctccaaca cggaggagga gcagacgctc aaccagcttc tggtagaaat ggatggtgcc    180
 tctcttgacc agctaccctc ccaggggacc atgaggaagc tcagaggaaa gacccccgcc    240
 tgctcctgtc tcacggagcc cacagggtca cggagggcaa tggagggtca ttcgctctgc    300
 tggggttgcc ttttgcactg aagatagaga ccaccttttt gagtgacttg agcccaaagg    360
 caagcgtata tcaaacgatc ttctccacat aacctctctg tgccatcata agaatagctg    420
 cttccgcccc cggatttgct caggcctggg aatccgctga ctgaaggcct cttgttgagt    480
 gccagctcta aacaagtccc tttatgcaga gccacagctg tgcatgctca gccctgccga    540
 ggtcccaggc caggctttgt tgcttccgtt catggaagcg cacaggatgg ggccgacgct    600
 gtgccggtcg tggggaaatc tcactgggga agagaaaagc ccaagccttg ttggttacgt    660
 cagccggtcc atggcggtgt cctgcggacc ccaaagcccc cgggaagggc gcaagtcaaa    720
 gagcactgga gg                                                        732



      <210> 2155
      <211> 1293
      <212> DNA
      <213> Homo sapiens


      <400> 2155
 tttttttttt ttaagaagaa aaaataataa acttagtttc tgtatgagca tccgcgtaag     60
 gaggcttctg attttctggt ctggtggagg gttgggtggg aacttgggca tcgtttttct    120
 cctccctctt gttcttgcaa agatcctagc acctgatctc tagcccagga ctatatgttc    180
 caggcagaaa tctacccaag aagagggaag attggtgaat ttgatgtggt agggtgcctt    240
 tccccagtca gtttgaagtc acagatatcc ttttcctctc atttcttttc cctcggttcc    300
 tagacgttcc tcggagctct ttgatgcctc agacctttcc cttttatccc tcttgctcag    360
 gtgcttcctt tcacaacttt ttccagaggg caggcgtcct agctccagtt gctccatccc    420
 ttgggccctc ccctgctctt catctagcca aactggtttg agtcagccac accccttccc    480
 agctccctgg gctcttcacg tggtggctgg ccactcaacc ccacccctgg gcttggcttg    540
 gagccctgag tcagctccat caccacccaa gccaaaccaa agctgaggca ggagccgaaa    600
 ctcagagtcc ttcaaggcct atagccaggt gatggaggac gaggagaagg cagtggagat    660
 cttgggcaac acggaagctg ctcatcctcc atcccccatc cgctgctgct ggctccgcct    720
 ccgctgcttg gcagctacta gcattatctg tggctgctct tgcctgggag tcatggctct    780
 ggtgtttgcc atcaaggcgg aagagcggca taaagcaggc cggtccgagg aggcagtgcg    840
 ctggggggcc cgggcccgga aactcatcct ggccagcttt gctgtctggc ttgctgtcct    900
 cattctgggt cccctgctgc tgtggttgct ctcctacgcc atcgctcagg ctgagtgacc    960
 ctggatggcc tctgctgaga gccagccgag acctcctgga tcctgcaatg cggcattgct   1020
 aaggtcctgt gacagcagtg gttggaagga tcctggttgg aaggatgggg actctctcaa   1080
 ggggctttgg aagagctctt ctagcccttt ataaaaggag ggcagcagct gagactgatg   1140
 agaggagggc agcctgctct gttctttcag ggccccccac ccccatctcc cctaccctag   1200
 cccaccctag ggcctctacc cagcgggagg ggttgaagac caggcctggt tttattagaa   1260
 ttcattttgt aataaaagcc ttttttagtg gtg                                1293



      <210> 2156
      <211> 1480
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> misc_feature
      <222> (1)...(1480)
      <223> n = a,t,c or g


      <400> 2156
 ctcaagaggc tgaggcagga gaatcacttg aacccggaag gcagaggttg agttgagctg     60
 agatcgtggc attgcactcc agcctaggca acgagagcga aactctgtct cagaaagtat    120
 actctgggtc taataatctg cctccttcag gaatattcat tcctcttgtt gcccgctgga    180
 tcccggcgct gttcatcggc ttcagccagt tctcggactc gttcctcctg gaccagccca    240
 acttctggtg ccgcggggcc ggcaaaggca ccgagctggc aggggtcacc accacaggcc    300
 ggggcgggga catgggcaac tggaccagcc tccccaccac ccccttcgcc actgccccct    360
 gggaggctgc gggcaaccgg agcaacagca gcggcgcgga cggaggcgac acaccacccc    420
 tgccatcccc tccggacaag ggggacaacg cctccaactg tgactgccgc gcatgggact    480
 acggcatccg cgccggcctc gtccagaacg tggtcagcaa gtgggatctt gtgtgtgata    540
 atgcctggaa ggtccatatc gctaagttct ccttactggt tggattaatc tttggctacc    600
 taataactgg atgcattgct gactgggtcg gccggcggcc tgtgctgctg ttttccatca    660
 tcttcattct gatctttgga ctgactgtgg cactgtcagt gaatgtgaca atgttcagca    720
 cactcaggtt ctttgaagga ttttgcctgg ctggaatcat tctcaccttg tatgctttac    780
 gaatagagct gtgcccccct ggaaaacggt tcatgattac gatggtggcg agcttcgtgg    840
 ccatggcggg ccagttcctc atgcctgggc tagccgccct gtgccgggat tggcaggtgc    900
 tgcaggccct catcatctgc cccttcctgc tcatgctgct ctactggtcg tgagtacact    960
 ctgcacagcg ccctgggctg gtgcgactgc acatgcttcc tgaaggcccg gccccgggca   1020
 ggacacacaa tccccacact ttccactagt tgcagcttgt ggttctgtct gagaaggttt   1080
 tcctctcttt ttaaaaaatt ttattgttta aactttctgt cttggaaaac tgttcaaata   1140
 tacacaaaaa tagaagagtg gaatgagccc atcacccagc tccaaaaatc tgcaaatgca   1200
 ctggccagtc tggctcaccc cttcttgcta cccaccccac ggggttattc tgacatgaat   1260
 ttttatgaat ggattgcagg gaggtggagt tcttgtgtta ggagggggga tttggagata   1320
 ttaaaggagt gatttacaaa agtcccccta tctcttctag gcgaggggtg ggcaaccttc   1380
 agcctgtggg ccacatcagg cccactgtct gtttttgtaa ataaagtttt attggaacac   1440
 nnnnnnnnnn nnnannnnnn nnnnnannan aaaaaaaaaa                         1480



      <210> 2157
      <211> 412
      <212> DNA
      <213> Homo sapiens


      <400> 2157
 ggaattcctg agttccaacc agatcaccca actgcccaac accaccttcc ggcccatgcc     60
 caacctgcgc agcgtggacc tctcgtacaa caagctgcag gcgctcgcgc ccgacctctt    120
 ccacgggctg cggaagctca ccacgctgca tatgcgggcc aacgccatcc agtttgtgcc    180
 cgtgcgcatc ttccaggact gccgcagcct caagtttctc gacatcggat acaatcagct    240
 caagagtctg gcgcgcaact ctttcgccgg cttgtttaag ctcaccgagc tgcacctcga    300
 gcacaacgac ttggtcaagg tgaacttcgc ccacttcccg cgcctcatct ccctgcactc    360
 gctctgcctg cggaggaaca aggtggccat tgtggtcagc tcgctggact gg            412



      <210> 2158
      <211> 688
      <212> DNA
      <213> Homo sapiens


      <400> 2158
 ttttcggcag aagggcccag ccttgagcct tgtgccctta acgcgggccg gcccgcccag     60
 gtgagcagct atatggccac ggtgtcgggg ctcctcaaga tcgtccaggc cttcgtggcc    120
 tgcatcatct tcggggcgct ggtccatgac agccgctacg ggcgctacgt ggccacccag    180
 tggtgcgtgg ccgtctacag cctgtgcttc ctggccacag tggccgtggt ggccctgagt    240
 gtgatgggcc acacaggggg cctgggctgc ccctttgacc ggctggtggt ggtgtacacc    300
 ttcctggctg tgctcctgta cctcagcgcc gccgtgatct ggccagtctt ctgtttcgat    360
 cccaagtacg gtgagcccaa acggcccccc aactgtgctc ggggcagctg tccctgggac    420
 agccagctgg tggtggccat cttcacctac gtcaacctgc tcctgtacgt cgttgacctc    480
 gcctactccc agaggattcg cttcgtgccc agcctgtagc ccacagtggc agcccaccca    540
 cctctgctct ctggccacca gctccaggtt ctgcgaggga aactcaggtg aaccaaagtg    600
 tcaagtagcg agcaggaggg aagccgcggg ctcaggggag atgaagtaca acgggagagg    660
 tcgctccccg acttccagac tgggctcc                                       688



      <210> 2159
      <211> 455
      <212> DNA
      <213> Homo sapiens


      <400> 2159
 actacaaaac atattttatt acaaagcact aaatacaatg cggataatcc cagactcaag     60
 acgtaattat tccaacacat atcctccagc agaagcagtt tccgagggga aaaccgaagc    120
 ctatgccttc cttcttccag gaatacgaag cggcccttgc ccctgtaggc ttcgtcctta    180
 ggttcccgtc atgaaggtaa tcagaagggt ttctttttca gcccaaagac ggtgacgaat    240
 aaagccattt cagtgacagc tggaagggca tgaatgtcct gcttgtcata ctcctcgggg    300
 gtgaacgtga gaggcaggca ggcctgtatg ttgctgtccc gggaccagaa taaggtgatg    360
 acgaccacca gatgcgccag gagcgtcagg aagcgagagg gcacaagccc tgagacccgg    420
 cccatggccc tcggggacaa gggcggcggt ctctg                               455



      <210> 2160
      <211> 641
      <212> DNA
      <213> Homo sapiens


      <400> 2160
 attacgccaa gcttggcacg aggctactgc cctcactgga cttggggggt ctggaccttt     60
 ggcccctgcc ccctggggga cccagacctc tgggccctca cttctggccc ttacagagat    120
 ccaggcatcc aacaccccca tccctgccca agcgtctgag gtgttagtgg tggggggaga    180
 agcccaccat cccagactct ggtaaatgtc tttgctggtt ccttgcagct ggcagtgggg    240
 gggaccccag cccaggccca ggcctaggcc tggggtgggg atagggtcag atgaagaatt    300
 cctctttcct cttgtgtccg tcgctgccat tgaggaaggc ttctcttgct tctccctgtt    360
 catccaagcc actggcttcg tgggtcagat aggaaccctt ctgccgtacc gagcaccaga    420
 ccatgcccac tagcacacat atgatcagaa acaccagcag cgccaggatg ccgcccacaa    480
 tggcataggg aaccgacgtc tgagcctcta ccaccgcacc agggtcgtag accacaagta    540
 cgtagagcgc cctcgcatgg ccgtgcttat tggacgcctc gcaagtgtag gtgccgttat    600
 ccgcggatac cagacccggg agcgtgagcc gctctcccac g                        641



      <210> 2161
      <211> 2604
      <212> DNA
      <213> Homo sapiens


      <400> 2161
 tttttttttt ttcttatttt ttaaacgttt attacttcaa gagggaatta tttttcaaag     60
 atgataaaac tcatttctat tccagtaaaa aagggtcaca ggtttgcccc cagggtccca    120
 ggagcgcccg gaaggcaggg ccccccaggc ctcttcacct cagcctgggg caccttataa    180
 tctgagggac cctgtgaagg gggtgggggc aagctcgggg gcacagcctg gcggccaact    240
 tcggccagac gagtggccgg ctcacgtcca taggatagat gtcagtttag gctgggaggg    300
 aaaagggcgc cagacaacca cgatgcagtg ccctgttgaa gacttccggg gggatcaaag    360
 tccgggcccg gggttgggcg gagaccctcg gggcagctgc acagggcatc tttgttgctt    420
 cactccattg ttttttccga ggcctgtgtt aaaggcgctt tgcctggcct ggcaggtaga    480
 ccaaggccaa agctctgtgg ccagggcctg ggcactgagt ccccactgaa tttggcacag    540
 gaaggcggca ctcccagcct ggcccgtcct gcatggggag ccaccacacc gggactgcag    600
 tgtttcacct tggaggggag gaagcctggg cccaacggct gaacgggaca ggccaggctc    660
 acccgaggaa ggggacgcag gacccacagc ccctgtggtc aaggcctgtg ggccaccgtg    720
 gaaagaaggt tccagaacag tgcttgttga cgagcctctc cctacaagtc ccttcagcag    780
 caagctccat ccctgagtgt ctgccacaag cctgcacgca tgtgtgtatg tgtgcccagg    840
 gcgtgtgtgc aggtgtgcaa caggcacatg gcagctggga ggctcaggct gtggggctgg    900
 ggggctgtcc cgctgggaga gtccgggaga agtggggtgt aggggctggg gggccggtca    960
 ggcccagcgg gccaggcctg gctggctcac ggtgtcctca ggaccctaca gttttgcttc   1020
 ctgcagcaca gagcccttgg gagctgatgt catcagggat tcagaatagg cctgaatggc   1080
 ctccttatcc tttgagccct ttttactact actccaaaat aaatagcatt tctcttggct   1140
 ccggatttgg cagatgacag ggaccagcag caggacgcag cccagcgcca ggaggacgta   1200
 ctgggcatag tgcatcacct tgggcatcaa caccagctga gtgtagaatg tgtgaagagt   1260
 ctccccctcc atggccccgc tctctgcaaa ccagagcagc ggcaggacca caggctcaat   1320
 cttcccagtt tgtccaatgc ctgcgacaga tttcatgtag aggctcagct gcagtttcac   1380
 agagcagttc atggggattc ccgtgaccgg gtggatgtcc aggaacaagg agtgtgcctc   1440
 ctggttaggg tgcaggccag tcaccgcttc tgccagaacc gggtcggcgt tgaggaagtg   1500
 aggatgggag agaaacaagg gggcactgaa cctgcaggtg ctgacgttct gaattccaga   1560
 ctccaggcac gggcagaagc cttcgttggg tgggtagatg gacccgttgg caaacagggt   1620
 tttgggagcc acgaagcgat aggtggggat gccttcaaac acccctgact ccttgtacat   1680
 tagcttcatg gatcggcagg cctccgggct gtagaactcc agcgaggact caggagtcat   1740
 gaagggcggc cacatttgcc cagaagttcc attgatcatg ttgcactgat cggaatgcca   1800
 gaagtcaacc ttgctcagcc cgttccactt gtccacgagg tggatcctgc tgatgttctg   1860
 gacccccgtg aaccccgtga agagcccaga gtcggagttg ttgagctcag caaataatcc   1920
 gaacttgtcc ttgaagggga acatgcctgg aaagtacttg ttgatgagat tcacaagggg   1980
 gtccttgtag ccccacatga tctcacccac agtgcggttc atgaaggcac gttcgccgag   2040
 ggtggtgaat gccaaggtca tgatgagctt cagggtcatg ggcttattct ccatcatcac   2100
 cgccgcaccc aagaccagga tgttgggcat gacgatgtag tcgctctccg agccgtggga   2160
 cttggagggc tggaactgga aggtgcggta ctcgaggaag gacacggtgt cgttgttgtt   2220
 gaaggtgatg ttgcttttgt gcctgaactc cctgtacacg tagggcccgc gctcccgcac   2280
 ctgcggcttc tcgcccttca ggatctcgct ggggttcatg acgtcaaaga agtagacgga   2340
 gagatagaag gggataggga tctccttcca catgttgaag gacaggctac tggggtcgat   2400
 gcgcacgttc ttaaggacct gctgcttgat gagcgacggc accatcacga tcatgacagc   2460
 gcccagcaca gcgcacagta gccccgcgac gcccagcgcc ccggcagccc agcgcgcttt   2520
 ggcggagcag cccatgtctg cgcgcctggg gcccacccgc ggctcgcagg gctccgcgcc   2580
 tggcaggaga cggggacggc gacg                                          2604



      <210> 2162
      <211> 474
      <212> DNA
      <213> Homo sapiens


      <400> 2162
 cactggtccc accatcaaga atatggatgg cacatttaat gtcactagct gcttgaagct     60
 gaactcctct caggaagacc ctgggactgt ctaccagtgt gtggtacggc atgcgtcctt    120
 gcataccccc ttgaggagca actttaccct gactgctgct cggcacagtc tttctgaaac    180
 tgagaagaca gataattttt ccattcattg gtggcctatt tcattcattg gtgttggact    240
 ggttttatta attgttttga ttccttggaa aaagatatgt aacaaatcat cttcagccta    300
 tactcctctc aagtgcattc tgaaacactg gaactccttt gacactcaga ctctgaagaa    360
 agagcacctc atattctttt gcactcgggc atggccgtct taccagctgc aggatgggga    420
 ggcttggcct cctgagggaa gtgttaatat taatacatat tcaacaactg tatt          474



      <210> 2163
      <211> 492
      <212> DNA
      <213> Homo sapiens


      <400> 2163
 aaaatcaaag caaagaatct cacaaactat gatctctgca gcatttttct tggaacctct     60
 acgctcttgg tttgggttgg agtcatcaga tacctgggtt atttccaggc atataatgtg    120
 ctgattttaa caatgcaggc ctcactgcca aaagttcttc ggttttgtgc ttgtgctggt    180
 atgatttatc tgggttacac attctgtggc tggattgtct taggaccata ccatgacaag    240
 tttgaaaatc tgaacacagt tgctgagtgt ctgttttctc tggtcaacgg tgatgacatg    300
 tttgcaacct ttgcccaaat ccagcagaag agcatcttgg tgtggctgtt cagtcgtctg    360
 tatttatatt ccttcatcag cctttttata tatatgattc tcagtctttt tattgcactt    420
 attacagatt cttatgacac cattaagaaa ttccaacaga atgggtttcc tgaaacggat    480
 ttgcaggaat tc                                                        492



      <210> 2164
      <211> 1513
      <212> DNA
      <213> Homo sapiens


      <400> 2164
 cttttttttt tatcattgat aggactaaac tgtcttcaac ttactaactg gagtttcttt     60
 acccagcagt tcagagcagt gagaactaca gaaggcgagg aggagacaga gagcaggtaa    120
 cggggcttta ccgtgacagc agtgcgttcc cctgctccac actcccactg actcagtctt    180
 gccaatgcca ctatcaaggt ccttgcaaaa atctggtttt cttttgtctg gaaagggctg    240
 gttttctcct ctgaaactga accccaactg ttggccctat ttaaatctca ggtcttggat    300
 ttcttactta cataagcagg ggcttaggta atagagtggg ttgtgcctgt ggagcctccc    360
 aatcagctct caacctcctc tgttggcagg gtccccggca gcacacggcc acagcgctcc    420
 ttcctctcaa gggtggtccg ggcagcccta cccctgcagc tgctcctcct gctgctgctg    480
 ctcctggcct gcctgctgcc ctcctccgaa gaagactaca gctgcactca ggccaacaac    540
 tttgcccggt ccttttaccc catgctgagg tacaccaatg ggccaccccc cacatagagg    600
 gcatagctgg ccacagtgct acaccacctg cctgattgcc aagggtgccc agcacgtggc    660
 cccagaccaa tctgagtgac ttagtgttgg caaggtcccg ggacctgtgc agacttcttc    720
 tgggcttacc cagcacgggc tccctggagc ccagggcagc tttcagattg tgttcctccc    780
 caggagcagg gaacctgtgt ggcaggtgcc ccgggtattt tggcagaact agttgattag    840
 tttagggatc tctggaaatg tcagtttcct gaagagccaa gcactttgtg aattctggtt    900
 tgtttgtaaa acagcattat tataatgtag gtatggtcaa tgagcagtgg tgtccatcac    960
 atatattata gaagcaagcg aggacattcc accctagaaa tggttcagaa actcataggc   1020
 acccttagct gatggaaaca atcaatcata tttaatacgc ttagaatcag ttttactcca   1080
 atcagctggc aattttgagc tgccggttat acaccaaaat gttctgttca gtacctagct   1140
 ctgctctttt atattgcttt aaatttttaa agaaattgta ttgcatggat gtggttattt   1200
 gtgcatattt tttaacaatg cccaatctgt atgaataatg taaacttcga ttttttttta   1260
 aaaaaattag attttagctg gagcttttga ctaatgtaaa gtaaatgcca aactaccgac   1320
 ttgataggga tgtttttgta agttaatttt ctaagacttt ttcacatcca aagtgatgct   1380
 ttgctttggg ttttaactgt ttggccacgg cgggggtggg ggcggggggt tggtacaaaa   1440
 acttgaagct gtttgtgata tgtacaactc agatgtttct cattaaaaaa caaaattagc   1500
 cagaaaaaaa aaa                                                      1513



      <210> 2165
      <211> 635
      <212> DNA
      <213> Homo sapiens


      <400> 2165
 cccgcacctg catgagtgag cgccatggtc cttcttcaca gagcgtcctg ctgtcacttt     60
 ggtttgtgtt aactttgacg cctttcttgg ttcttactct gctttcctgc atggagcaca    120
 cagccccggc tccctttcag tctgcatggc agacacctgg cctctgcagg gccagatcat    180
 tctgtgtccc ctttcggtcg tccctatgtt gccgtcaggc gattgagggt gaaggtcggc    240
 cttggcagcc cagtggaaag tcccttgact cctggtcgtc agtggcaggt ctccagcctt    300
 tgggaggagg aaacttctat ttaacaaaga aatggaattg actttgccac acacagccag    360
 agcgatgatt tgtagagcca acctgctgag acattcaaag catcagtcgt agggtcagga    420
 ccgccaggtg aggtgtggct ccacctgcag cagcctgggg caggttgcct agcctctggc    480
 tttagcatcc ccttctgtga aatggggaaa gtgatgggac ctggctttgt agggtggttg    540
 tgaggaccca cacgcgtttt tgcaaaaaac tcaccccccc gccgcctaaa agatcaaaaa    600
 cgcttggcat ggggcccaca cctggatttc aggtt                               635



      <210> 2166
      <211> 443
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> misc_feature
      <222> (1)...(443)
      <223> n = a,t,c or g


      <400> 2166
 ntcgtagttc ctagtccatg tggtggaatt ctgggcggcg gngccggggt aggtggcgat     60
 tccgagggtg aagtgaccag tgcgctgagc gccaccttca gcggccccaa gatcgccttc    120
 tatgtgggtc tcaagagccc ccacgaaggc tatgaggtgc tgaagttcga tgacgtggtc    180
 accaacctcg gcaatcacta tgaccccacc acgggcaagt tcagctgcca ggtacgcggc    240
 atctacttct tcacctacca catcctcatg cgcggcggcg acggcaccag catgtgggcg    300
 gacctctgca agaacgggca ggtccgggcc agcgccattg cacaggacgc cgaccagaac    360
 tacgactacg ccagtaacag cgtggtgctg cacttggatt caggggacga agtgtatgtg    420
 aagctggatg gcgggaaggc tca                                            443



      <210> 2167
      <211> 416
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> misc_feature
      <222> (1)...(416)
      <223> n = a,t,c or g


      <400> 2167
 acccccctca gaagagcgat cccccctaca agttggttcc tgtacactta gatagtattc     60
 tctaaggcat ccactgcatt tcctttcatt tgacatagct tctgttacaa ttgcatccac    120
 gttttctttt cttttgttga ttttcttgtt cccgtagaag aaagaagaaa ggtgtttgga    180
 gaattcgagt gcctaggatg ccagaccaga gttgagacaa aaagaaataa gattattttc    240
 tgctttgtag ttctgtactt ttcgagagaa gggaataggg aagacagcaa agaaagattc    300
 agatttctaa ccctgcaact tttgccaagc tttattgccc tgtgttcaca gcaataaaac    360
 cacttcctgc tgcttctana nnannnnnnn nnnnnnnnnn nnnnnggggg gggggc        416



      <210> 2168
      <211> 899
      <212> DNA
      <213> Homo sapiens


      <400> 2168
 tttcgtgcgt ccccggccca accatggcgt cctccgcggc cggctgcgtg gtgatcgttg     60
 gcaggaagtc tgaaacagca gttggagtgt agtggttaag aggaaggact caggagtcag    120
 attgcttggc ttcatctcat agatccataa cttatcaccc ttgtggactt aattcctcca    180
 tgcctcagtt tatcacttat gtaggcttaa ttcctccatg cctcagtttc cctacatata    240
 aaatggaaat actaataaca cttatcttgt agggttgttg taaagattaa catagtggag    300
 tcattgggcg aagctgggcc atgctgtttg ccagtggagg cttccaggtg aaactctatg    360
 acattgagca acagcagata aggaatgccc tggaaaacat caggtgggcc agccggcgct    420
 ctccagaagg aatggaagtg ggtctgtttc tctcagttgg tcttgtttgt catatcctca    480
 aggctatgag gatctgtgat gtcacatttt cgtctgatgg ctactgcagt gcctctgagt    540
 tggtaaaggc caggcctaca gtggctggaa tgtgaattca cactggggaa gggctcccat    600
 gggggaggaa acgacccttc ttgctaagag gatctgcatc aagcgtgagt gactttgcag    660
 gcttctccag ctgtttgccc cggggctgga gggctggggt ttcctgcttc catctaggca    720
 ggaggaactc gcttccagca tgtgacagcc atagctgcag gggcattaca gtttaagaac    780
 agaggtcctg cagcttgttt tgacctgttg atctagtaat ggtaggaccc aaatgaaaac    840
 atcttgaatt ttagttagag gtttagcact catgtgagag gacagaactg gagctgttt     899



      <210> 2169
      <211> 899
      <212> DNA
      <213> Homo sapiens


      <400> 2169
 tttcgtgcgt ccccggccca accatggcgt cctccgcggc cggctgcgtg gtgatcgttg     60
 gcaggaagtc tgaaacagca gttggagtgt agtggttaag aggaaggact caggagtcag    120
 attgcttggc ttcatctcat agatccataa cttatcaccc ttgtggactt aattcctcca    180
 tgcctcagtt tatcacttat gtaggcttaa ttcctccatg cctcagtttc cctacatata    240
 aaatggaaat actaataaca cttatcttgt agggttgttg taaagattaa catagtggag    300
 tcattgggcg aagctgggcc atgctgtttg ccagtggagg cttccaggtg aaactctatg    360
 acattgagca acagcagata aggaatgccc tggaaaacat caggtgggcc agccggcgct    420
 ctccagaagg aatggaagtg ggtctgtttc tctcagttgg tcttgtttgt catatcctca    480
 aggctatgag gatctgtgat gtcacatttt cgtctgatgg ctactgcagt gcctctgagt    540
 tggtaaaggc caggcctaca gtggctggaa tgtgaattca cactggggaa gggctcccat    600
 gggggaggaa acgacccttc ttgctaagag gatctgcatc aagcgtgagt gactttgcag    660
 gcttctccag ctgtttgccc cggggctgga gggctggggt ttcctgcttc catctaggca    720
 ggaggaactc gcttccagca tgtgacagcc atagctgcag gggcattaca gtttaagaac    780
 agaggtcctg cagcttgttt tgacctgttg atctagtaat ggtaggaccc aaatgaaaac    840
 atcttgaatt ttagttagag gtttagcact catgtgagag gacagaactg gagctgttt     899



      <210> 2170
      <211> 2148
      <212> DNA
      <213> Homo sapiens


      <400> 2170
 aaaacctcca gcaggtttta ggaagtattc atgtattttt ctggttactt tctgtcatct     60
 ctaattgaac tcacctgatg aaggttcagt gttctggggc cagaatttat gattttagat    120
 caccttcttt ggaaccttag atcactgtgt tttgaaatca tgagtttgct tttaacttca    180
 tagggtcaac tttaaaatga tatgcactgt taattttaaa gcatttgctg cagataatta    240
 aacttagaag tgcctttgac tttaggatac aaatattaca gaagaaaata taatttcact    300
 ttttaaaatt ggggtgggaa aatcccattg catatttgaa ataggctttt catactaagc    360
 ttcatagcca ggagtcccca gagtcttgtt cctctgaaag ccactgggga gtggcctctg    420
 gggtgctgat tccacagagg tgtatgctgt agacaggaga gtgccatcta tgccaaaact    480
 cgccctcaaa aacaaacaag gcttgctggg aggcgtgctg ggcttggcca tcagtatttc    540
 cagtgtggta aactattgct ggcacttccc cctggaaata actaatgagg ttacgagttg    600
 ggcacctgca cagatgtcct tctctcatag ttcctaatgc ttaggaatag aggagaaata    660
 aaaaaatgga ttctctcaaa acactgccat ttgaatagcg acagaagtgc tcccccagcc    720
 cccaactttg gacagcaaag ttgaggagaa tgagcagaca cagttgtttg cttgatctga    780
 atctctctaa agtaaagtat ttccaaactg tgtgacaaga gcctacctac cactgtagcg    840
 gtcaaagctg aagcttctta cagcagtgaa acggggcacc acctccccca cactcctcat    900
 tccccgctta aaacatggat actttcaaat ttgactgttt cttaaactgc catcctaaga    960
 tatggaaaat ttttatagta aagtgtctag ttagcttatt tccttttcta aaacaagtgt   1020
 tttcaagata actgtatttt acctttatat gtactgaata gctgtttctt tttgaattat   1080
 ttgcctttta aaatttgata atgtctctgg atataacagg acaggagttc ttaaaaaata   1140
 tcttaagaaa ttcactttat gggtaaaccc aaggtttttg ccaacttgtt gcctagaaaa   1200
 taagggctag tttcagttta tacaaataga attattaaac attttacagt ccttgattag   1260
 aaaccagacc caatctcctt ataacaccac agcgtatcct gccattgaca gtgtaatcac   1320
 aattctccct ttttcattta gctgcttttt tattattact aaatgttttg gattgagcat   1380
 ttttccctct gtaattttct tccttcacgt ttattttatt ttaactcttg tagtatttta   1440
 ttgttgttaa tttacaagtt taaaaatatt aggtactatt aataatggtt aaaaatagaa   1500
 aaatgcatat ttttgtatga taatcaaatg taaaatactt ttatttttgc tggacagttg   1560
 ttatatcatg attattgtgc tacagtttat tgtgcataat atgaaaaaca actatgacag   1620
 ccttcagtcg ggccagggtg aagctgctta taccacctct gccgtcagag ggacatgtgg   1680
 tgacagcagt ggtgtggctg cacagggcgc actagagaga gctcagcacc cctgctgccc   1740
 gccagcagag cccgtgctga gggaatgccg cacagatgct gatgcactgg gtgaaatttc   1800
 tagtattgaa cgtaaaggtg tacagtgtct tgctgttatt ttatgatgga aactgatttt   1860
 gaaaccaaaa atagctaact aactttattt aaggaaagga tattaatttg tactaacaga   1920
 gggtgaaagc tgttcacatt tgtcaacaaa atctgcttgc tgcagtagta acctcaagtg   1980
 gttaaaactt gatttcccga gaaaactaaa acctttgtgc ctaaaattga tgacttgagt   2040
 tcaagtggga tgagcaagaa gatgtgttat cttgttgttc aacagtattg agtgtgaagg   2100
 aaattttgat ggcttaataa aattccacag cgactgttaa aaaaaaaa                2148



      <210> 2171
      <211> 5612
      <212> DNA
      <213> Homo sapiens


      <400> 2171
 acgacgattt cgcgttggta aaagggtcca gagtggcagt aaaggaggaa gatggcgggg     60
 tgcagggggt ctctgtgctg ctgctgcagg tggtgctgct gctgcggtga gcgtgagacc    120
 cgcacccccg aggagctgac catccttgga gaaacacagg aggaggagga tgagattctt    180
 ccaaggaaag actatgagag tttggattat gatcgctgta tcaatgaccc ttacctggaa    240
 gttttggaga ccatggataa taagaaaggt cgaagatatg aggcggtgaa gtggatggtg    300
 gtgtttgcca ttggagtctg cactggcctg gtgggtctct ttgtggactt ttttgtgcga    360
 ctcttcaccc aactcaagtt cggagtggta cagacatcgg tggaggagtg cagccagaaa    420
 ggctgcctcg ctctgtctct ccttgaactc ctgggtttta acctcacctt tgtcttcctg    480
 gcaagcctcc ttgttctcat tgagccggtg gcagcaggtt ccgggatacc cgaggtcaaa    540
 tgctatctga atggcgtaaa ggtgccagga atcgtccgtc tccggaccct gctctgcaag    600
 gtccttggag tgctgttcag tgtggctgga gggctcttcg tggggaagga aggccccatg    660
 atccacagtg gttcggtggt gggagctggc ctccctcagt ttcagagcat ctccttacgg    720
 aagatccagt ttaacttccc ctatttccga agcgacaggt atggaaagag acaagagaga    780
 ctttgtatca gcaggagcgg ctgctggagt tgctgcagct ttcggggcgc caatcggggg    840
 taccttgttc agtctagagg agggttcgtc cttctggaac caagggctca cgtggaaagt    900
 gctcttttgt tccatgtctg ccaccttcac cctcaacttc ttccgttctg ggattcagtt    960
 tggaagctgg ggttccttcc agctccctgg attgctgaac tttggcgagt ttaagtgctc   1020
 tgactctgat aaaaaatgtc atctctggac agctatggat ttgggtttct tcgtcgtgat   1080
 gggggtcatt gggggcctcc tgggagccac attcaactgt ctgaacaaga ggcttgcaaa   1140
 gtaccgtatg cgaaacgtgc acccgaaacc taagctcgtc agagtcttag agagcctcct   1200
 tgtgtctctg gtaaccaccg tggtggtgtt tgtggcctcg atggtgttag gagaatgccg   1260
 acagatgtcc tcttcgagtc aaatcggtaa tgactcattc cagctccagg tcacagaaga   1320
 tgtgaattca agtatcaaga catttttttg tcccaatgat acctacaatg acatggccac   1380
 actcttcttc aacccgcagg agtctgccat cctccagctc ttccaccagg atggtacttt   1440
 cagccccgtc actctggcct tgttcttcgt tctctatttc ttgcttgcat gttggactta   1500
 cggcatttct gttccaagtg gcctttttgt gccttctctg ctgtgtggag ctgcttttgg   1560
 acgtttagtt gccaatgtcc taaaaagcta cattggattg ggccacatct attcggggac   1620
 ctttgccctg attggtgcag cggctttctt gggcggggtg gtccgcatga ccatcagcct   1680
 cacggtcatc ctgatcgagt ccaccaaatg agatcaccta cgggctcccc atcatggtca   1740
 cactgatggt gggcaaatgt acaggggact ttttcaataa gggcatttta tgatatccac   1800
 gtgggcctgc gaggcgtgcc gcttctggaa tgggagacag aggtggaaat ggacaagctg   1860
 agagccagcg acatcatgga gcccaacctg acctacgtct acccgcacac ccgcatccag   1920
 tctctggtga gcatcctgcg caccacggtc caccatgcct tcccggtggt cacagagaac   1980
 cgcggtaacg agaaggagtt catgaagggc aaccagctca tcagcaacaa catcaagttc   2040
 aagaaatcca gcatcctcac ccgggctggc gagcagcgca aacggagcca gtccatgaag   2100
 tcctacccat ccagcgagct acggaacatg tgtgatgagc acatcgcctc tgaggagcca   2160
 gccgagaagg aggacctcct gcagcagatg ctggaaagga gatacactcc ctaccccaac   2220
 ctataccctg accagtcccc aagtgaagac tggaccatgg aggagcggtt ccgccctctg   2280
 accttccacg gcctgatcct tcggtcgcag cttgtcaccc tgcttgtccg aggagtttgt   2340
 tactctgaaa gccagtcgag cgccagccag ccgcgcctct cctatgccga gatggccgag   2400
 gactacccgc ggtaccccga catccacgac ctggacctga cgctgctcaa cccgcgcatg   2460
 atcgtggatg tcaccccata catgaaccct tcgcctttca ccgtctcgcc caacacccac   2520
 gtctcccaag tcttcaacct gttcagaacg atgggcctgc gccacctgcc cgtggtgaac   2580
 gctgtgggag agatcgtggg gatcatcaca cggcacaacc tcacctatga atttctgcag   2640
 gcccggctga ggcagcacta ccagaccatc tgacagccca gcccaccctc tcctggtgct   2700
 ggcctgggga ggcaaatcat gctcactccg ggcggggcac agctggctgg ggctgtttcc   2760
 ggggcattgg aaagattccc agttacccac tcactcagaa agccgggagt catcggacac   2820
 cttgctggtc agaggccctg ggggtggttt tgaaccatca gagcttggac ttttctgact   2880
 tccccagcaa ggatcttccc acttcctgct ccctgtgttc cccaccctcc cagtgttggc   2940
 acaggcccca cccctggctc caccagagcc cagaagccag aggtaagaat ccaggcgggc   3000
 cccgggctgc actcccgagc agtgttccct ggcccatctt tgctactttc cctagagaac   3060
 cccggctgtt gccttaaatg tgtgagaggg acttggccaa ggcaaaagct ggggagatgc   3120
 cagtgacaac atacagttgc atgactaggt ttaggaattg ggcactgaga aaattctcaa   3180
 tatttcagag agtccttccc ttatttggga ctcttaacac ggtatcctcg ctagttggtt   3240
 ttaagggaaa cactctgctc ctgggtgtga gcagaggctc tggtcttgcc ctgtggtttg   3300
 actctcctta gaaccaccgc ccaccagaaa cataaaggat taaaatcaca ctaataaccc   3360
 ctggatggtc aatctgataa taggatcaga tttacgtcta ccctaattct taacattgca   3420
 gctttctctc catctgcaga ttattcccag tctcccagta acacgtttct acccagatcc   3480
 tttttcattt ccttaagttt tgatctccgt cttcctgatg aagcaggcag agctcagagg   3540
 atcttggcat cacccaccaa agttagctga aagcagggca ctcctggata aagcagcttc   3600
 actcaactct ggggaatgct accatttttt ttccaaagta gaaaggaagc acttctgagc   3660
 cagtgaccac tgaaaggtat gtgctatgat aaagcagatg gcctatttga ggaagagggt   3720
 gtctgccctt cacaaacacc tctctctccc ctgcactagc tgtcccaagc ttacatacag   3780
 aggcccttca ggagggcctc ctgtggccgc agggagggtg cgtggggaag atgcttcctg   3840
 ccagcacgtg cctgaaggtt tcacatgaag catgggaagc gcaccctgtc gttcagtgac   3900
 gtcattcttc tccaggctgg cccgccccct ctgactaggc acccaaagtg agcatctggg   3960
 cattgggcat tcatgcttat cttcccccac cttctacatg gtattagtcc cagcaggcat   4020
 ccctggggca gacgtgcttt ggctcaagat ggccttcatt tacgtttagt tttttttaaa   4080
 accgtggagg ttgcccacgg gcctcggcac ctgggccctg gcagcacagc tctcaggccc   4140
 agccctgggc gacctccttg gccaagtctg cctttcaccc tgggggtgag catcagtcct   4200
 ggctctgctg gtccagatct tgcgctcagc acactctagg gaataattcc actccagaga   4260
 tggggctgct tcaaggtctt ttctagctga ttgtggcccc tccattttcc gcattttctt   4320
 atctccctga ccaaaattgc tttgacttct aaatgtttct gcttcccaga atgcacctga   4380
 cttatgaaat ggggataata ctcccaggaa atagcgcagg acatcacaag gaccaaaaag   4440
 gcaattctta tttaaatgtt actatttggc cagctgctgc tgtgttttat ggcagtgttc   4500
 aaagcttgat cacgttattt cttcctttta ttaagaagga agccaattgt ccaagtcagg   4560
 agaatggtgt gatcacctgt cacagacact ttgtcccctc tccccgcccc ttcctggagc   4620
 tggcagagct aacgccctgc aggaggaccc cggcctctcg agggctggat cagcagccgc   4680
 ctgccctgag gctgccccgg tgaatgttat tggaattcat ccctcgtgca catcctgttg   4740
 tgtttaagtc accagatatt ttgttcccat cagtttagcc cagagataga cagtagaatg   4800
 caaatacctc cctcccctaa actgactgga cggctgccaa ggaggcccca aacccaggcc   4860
 ccatgcaaag gcacgtggtt tccttttctc ctctctctgc atctgcgctt tccagataag   4920
 cccaaagaca gcaacttctc cactcatgac aaatcaactg tgaccctcgc tccttccatt   4980
 tctgtccatt agaaaccagc cttttcagca tctcacccat tagcagcccc atcacccagt   5040
 gatcagtcgc ctcagtaaag cagatctgtg gatggggagc ctacgggtgg taagaagtgg   5100
 tgttttgtgt ttcatctcca gcttggtgtt ccatggcccc taggcgaggt gatcagggag   5160
 tggggccaat gggcccccgg ccctggcttt gggaccttgt gctgagggat gatttgctcc   5220
 tgaccttgat taacttaaca gttcccagct ggaagggaca ctttcaggac ccagtccact   5280
 gtatggcatt tgtgatgcag aattatgcac tgacatgacc ctgggtgaca ggaaagcctt   5340
 tcgagaggcc caaggtggcc tcgccagccc tgcagtattg atgtgcagta ttgcaccaca   5400
 gctctgcgga ccttggccat tgccgcagtc gcagcttcct tttttctgtt tgcactgttt   5460
 gtttgtatga tgttagctaa ttccactgtg tatataaatt gtattttttt taatttgtaa   5520
 aatgctattt ttatttgaac ctttggaact tgggagttct cattgtaacc ctaacatgtg   5580
 agaataaaat gtcttctgtc tcaaaaaaaa aa                                 5612



      <210> 2172
      <211> 391
      <212> DNA
      <213> Homo sapiens


      <400> 2172
 ccatgatcaa ggtctgtttt atctccagcg tcacgttctg tggctccaac gtcttgaccc     60
 acttcttctg tgacatttcc cccatcctca agctggcctg cacggacttc tccactgcag    120
 agctggtgga tttcattctg gccttcatca tcctggtgtt tccactcctg gccaccatgc    180
 tgtcatatgc gcacattacc ctggctgtcc tgcgcatccc ctcggccacc ggctgctgga    240
 gagccttctt cacctgcgcc tctcacctca ccgtggtcac cgtcttctat acagccttgc    300
 ttttcatgta tgtccggccc caggccattg attcccggag ctccaacaag ctcatctctg    360
 ttttgtacac agttatcacc cccagtgtat t                                   391



      <210> 2173
      <211> 557
      <212> DNA
      <213> Homo sapiens


      <400> 2173
 gggtcgaccc acgcgtccgg ctcaccacct ggggagattg tatctttagg aatattgagt     60
 gaaggccagt ttggtattcc gaaagggatc gtcttttcta tgcctgtgaa atttgagaat    120
 ggaacttggg tggttcttac agatctcaaa gatgttgaaa taagtgaaca aataatgacc    180
 cgaatgacaa gtgatctaat tcaggagaaa cttgttgcac ttggagacaa gatacatttt    240
 cagccatacc aatcaggaca taaagatctg gtccctgatg aagaaaaaaa tctagctatg    300
 tcagatgcag cagagtttcc aaatcagatt cctcaaacca cctttgaaaa gccacagagt    360
 cttgagttcc taaatgaatt tgaaggcaaa accgtggaat cctaacagat caaattggat    420
 gaaatatata attacttgat agcacaataa acatagaaag aatttatatg aatgtctata    480
 tttaaggaag aataatttga aagatttatg tcagtcttag ataataccat gcaaggcaat    540
 taaatcactg tgacagc                                                   557



      <210> 2174
      <211> 2685
      <212> DNA
      <213> Homo sapiens


      <400> 2174
 gcggccgcgg cggcggctgg ggcgttcgcg ggccggcgcg cggcgtgcgg ggccgtgctg     60
 ctgacggagc tgctggagcg cgccgctttc tacggcatca cgtccaacct ggtgctattc    120
 ctgaacgggg cgccgttctg ctgggagggc gcgcaggcca gcgaggcgct gctgctcttc    180
 atgggcctca cctacctggg ctcgccgttc ggaggctggc tggccgacgc gcggctgggc    240
 cgggcgcgcg ccatcctgct gagcctggcg ctctacctgc tgggcatgct ggccttcccg    300
 ctgctggccg cgcccgccac gcgagccgcg ctctgcggtt ccgcgcgcct gctcaactgc    360
 acggcgcctg gtcccgacgc cgccgcccgc tgctgctcac cggccacctt cgcggggctg    420
 gtgctggtgg gcctgggcgt ggccaccgtc aaggccaaca tcacgccctt cggcgccgac    480
 caggttaaag atcgaggtcc ggaagccact aggagatttt ttaattggtt ttattggagc    540
 attaacctgg gagcgatcct gtcgttaggt ggcattgcct atattcagca gaacgtcagc    600
 tttgtcactg gttatgcgat ccccactgtc tgcgtcggcc ttgcttttgt ggtcttcctc    660
 tgtggccaga gcgttttcat caccaagcct cctgatggca gtgccttcac cgacatgttc    720
 aagatactga cgtattcctg ctgttcccag aagcgaagtg gagagcgcca gagtaatggt    780
 gaaggcattg gagtctttca gcaatcttct aaacaaagtc tgtttgattc atgtaagatg    840
 tctcatggtg ggccatttac agaagagaaa gtggaagatg tgaaagctct ggtcaagatt    900
 gtccctgttt tcttggcttt gataccttac tggacagtgt atttccaaat gcagacaaca    960
 tatgttttac agagtcttca tttgaggatt ccagaaattt caaatattac aaccactcct   1020
 cacacgctcc ctgcagcctg gctgaccatg tttgatgctg tgctcatcct cctgctcatc   1080
 cctctgaagg acaaactggt cgatcccatt ttgagaagac atggcctgct cccatcctcc   1140
 ctgaagagga tcgccgtggg catgttcttt gtcatgtgct cggcctttgc tgcaggaatt   1200
 ttggagagta aaaggctgaa ccttgttaaa gagaaaacca ttaatcagac catcggcaac   1260
 gtcgtctacc atgctgccga tctgtcgctg tggtggcagg tgccgcagta cttgctgatt   1320
 gggatcagcg agatctttgc aagtatcgca ggcctggaat ttgcatactc agctgccccc   1380
 aagtccatgc agagtgccat aatgggcttg ttctttttct tctctggcgt cgggtcgttc   1440
 gtgggttctg gactgctggc actggtgtct atcaaagcca tcggatggat gagcagtcac   1500
 acagactttg gtaatattaa cggctgctat ttgaactatt acttttttct tctggctgct   1560
 attcaaggag ctaccctcct gcttttcctc attatttctg tgaaatatga ccatcatcga   1620
 gaccatcagc gatcaagagc caatggcgtg cccaccagca ggagggcctg accttcctga   1680
 ggccatgtgc ggtttctgag gctgacatgt cagtaactga ctggggtgca ctgagaacag   1740
 gcaagacttt aaattcccat aaaatgtctg acttcactga aacttgcatg ttgcctggat   1800
 tgatttcttc tttccctcta tccaaaggag cttggtaagt gccttactgc agcgtgtctc   1860
 ctggcacgct gggccctccg ggaggagagc tgcagatttc gagtatgtcg cttgtcattc   1920
 aaggtctctg tgaatcctct agctgggttc ccttttttac agaaactcac aaatggagat   1980
 tgcaaagtct tggggaactc cacgtgttag ttggcatccc agtttcttaa acaaatagta   2040
 tcacctgctt cccatagcca tatctcactg taaaaaaaaa aattaataaa ctgttactta   2100
 tatttaagaa agggaggatt tttttttttt aaagataaaa gcatggtcag atgctgcaag   2160
 gattttacat aaaggccata tttatggttt ccttcctgaa aacagtcttg ctcttgccat   2220
 gttctttgat ttaggctggt agtaaacaca tttcatctgc tgcttcaaaa agtacttact   2280
 ttttaaacca tcaacattac ttttctttct taaggcaagg catgcataag agtcatttga   2340
 gaccatgtgt cccatctcaa gccacagagc aactcacggg gtacttcaca ccttacctag   2400
 tcagagtgct tatatatagc tttattttgg tacgattgag actaaagact gatcatggtt   2460
 gtatgtaagg aaaacattct tttgaacaga aatagtgtaa ttaaaaataa ttgaaagtgt   2520
 taaatgtgaa cttgagctgt ttgaccagtc acatttttgt attgttactg tacgtgtatc   2580
 tggggcttct ccgtttgtta atactttttc tgtatttgtt gctgtatttt tggcataact   2640
 ttattataaa aagcatctca aatgcgaaat ccatgaaaaa aaaaa                   2685



      <210> 2175
      <211> 393
      <212> DNA
      <213> Homo sapiens


      <400> 2175
 ttcgccattc gtgctgttct cctcaacttt ggcgctgcct tccttaccct ccatgctgcc     60
 gtcgctggcc accgtgctgc tctctctgac ctcctcgctg cccctggcct ctacactact    120
 ctcactggtc cccgtgcttc cttccttggc cttcaggctg ccgtccttgg cttccattct    180
 gccctccttg gccttgacct caccttcatg ctggcggcga aactcactct catcctggaa    240
 ctcctccatc ttctctgctc cctcttcatc ctcattctcc acacagtcct tgactcgcac    300
 ttccaagctg cgtctcttga cattgtacag cagagcatgc tgcctccggg ctgcacagaa    360
 caccacggag tagcaggcaa tcatgacaat cag                                 393



      <210> 2176
      <211> 412
      <212> DNA
      <213> Homo sapiens


      <400> 2176
 aatacagctc gccgtctttt ccaaactcca ttaaaactgt tgcccagact gccatgaaaa     60
 cagcagagaa gacagtggct ccattgtcaa aaaggtgggt taccttggca tatacacagc    120
 tgtctgacag cctcatgaat ggacagtatt tatcacacac aggacacatg atgatatctg    180
 tagcttggca gacttcttta ctgacttggc tgtgatccac agtggtgacg ccatacaaaa    240
 agacaaacaa tccaatgaag gcagctggga aaagcatgcc ggtgtaccaa cccaaccaag    300
 caaaatataa cccaatcttc tctccaaagt accgccttac aagatccaaa ggttggtatt    360
 tataccacac gccccaggag gcccagcact catagagtag atgtcggtgg tt            412



      <210> 2177
      <211> 779
      <212> DNA
      <213> Homo sapiens


      <400> 2177
 ggaattccag tggtagccag gatggaaggc acctcccaag ggggcttgca gaccgtcatg     60
 aagtggaaga cgggggttgc catctttgtg gttgtggtgg tctaccttgt cactggcggt    120
 cttgtcttcc gggcattgga gcagcccttt gagagcagcc agaagaatac catcgccttg    180
 gagaaggcgg aattcctgcg ggatcatgtc tgtgtgagcc cccaggagct ggagacgttg    240
 atccagcatg ctcttgatgc tgacaatgcg ggagtcagtc caataggaaa ctcttccaac    300
 aacagcagcc actgggacct cggcagtgcc tttttctttg ctggaactgt cattacgacc    360
 atagggtatg ggaatattgc tccgagcact gaaggaggca aaatcttttg tattttatat    420
 gccatctttg gatttccact ctttggtttc ttattggctg gaattgaaga ccaacttgga    480
 accatctttg ggaaaagcat tgcaagagtg gagaaggtct tttgaaaaaa gcaagtgagt    540
 cagaccaaga ttcgggtcat ctcaaccatc ctgttcatct tggccggctg cattgtgttt    600
 gtgacgatcc ctgctgtcat ctataagtac ttcgagggct ggacggcttt ggagtccatt    660
 tactttgtgg tggtcactcc gcccacggtg ggctttggtg attttgtggc agggaaaacc    720
 gctggcatca attatcgaga ggtgtattcg cccgctgtgg ggtctcccta attccagac     779



      <210> 2178
      <211> 1221
      <212> DNA
      <213> Homo sapiens


      <400> 2178
 ttccttctgc atagcgtttt atggttcttc actctctcag tttcaggcag gaagactcat     60
 cctgagctga gctgcttttc ttgaagttgt gcaagaacgt cctgttggct ggggcaaatt    120
 cagtatttct tttcctggcc actgtgctgg agcgtgagga aagactctcc accctcactc    180
 ccagatcctg caggaggcgt gagagcggat ggagatggtg aggatgtcta ttaatatggt    240
 gtttcctgca aaacggtgcc catctcaacc atgggttgtc aaccatcctc ggtgtctaca    300
 actgcaattt acctttgagg gcccatgaac tctgattacc tgaaagtcct taggccagaa    360
 agagaaaccc ctgtccccca cctctcactt tcacctattt ctagaccttt tcttacagca    420
 atgccttggc cctcaggaag catcagatct caaactgcag ggtctggggc tgaagctgat    480
 gctggcatgg gtgactcaga gttcctctat tagttcaaat atgtaatatc ttttagagcc    540
 taggactcag gctggaggca attccttggt gccagttggt taatacttta tgaatagtgg    600
 tgggggaggg aatgccttgg actattaatg tccccatgga tctggatcct ggagaacttc    660
 cagtgtcctg gatggaatgt tctgcttggc tcatcttgcc cagagaagag ccaggatatg    720
 agaagatggg agagggaagg gggaggtgtg aaacgtgctg gtgcttcctg tcctcgtggt    780
 gtgatggctg cccaggctgc tccttcgagg caggacagga ttcccatggg agatatgagg    840
 accatggtga tttccaggca ccagttatgt cccagagcat cgtgtgcctg tgcagtgggg    900
 ttactgatag tccaggcatc agttcatatt gtcctttatg gcagatcctg cacaaggggg    960
 ttctctgtct ctggacccac tctgtcagca tggacatcct ttttcttttt ccctgagcag   1020
 gggcaccagt gccaggcaga gaagagagta accagcatca ggagcagcga gacaggcacc   1080
 accaccagca gcacatcttt gtaggaggcc ttccctggtg ctgcctcatg atgacagcta   1140
 tcccagggcg tgactgtggc caagtcccag ctgacagggt tggagacaat gcaggaatag   1200
 gccacatctc tgtctccggt a                                             1221



      <210> 2179
      <211> 1084
      <212> DNA
      <213> Homo sapiens


      <400> 2179
 cagtgcggtg gaattccagc ccagcctcgg tgtccagcag cccggcccgc gcgctcctgc     60
 tggtcggcgt cttcctcctg gcctactggt tcttgtccct gaccctgggc ttcactttca    120
 gcgtcctgca cgtggtgttc ggccgcttct tctggatcgt gcgggtcgtc ctgttttcca    180
 tgtcctgcgt gtacatcctg cacaagtacg agggcgagcc ggagaacgcg gtgctgccgc    240
 tgtgcttcgt ggtggccgtc tacttcatga ccgggcccat gggcttctac tggcgaagca    300
 gtcccagcgg ccccagcaac cccagcaacc ccagcgtgga ggagaagctg gagcacctgg    360
 agaagcaggt cagactgctc aacatccgtc tcaaccgggt gctcgagagc ctggaccgct    420
 ccaaggacaa gtgaaggtca gccggccggg cgggtccaca gttaccagca cgctgtctca    480
 gaaaacgaaa acggaggaaa aaaaccccaa accccaaaca atcttaataa acacgactga    540
 gcaagaaagt ggcgctgtgt aaggctattt ccacccaccc ggcagctctt aggacacatt    600
 cccagaagag cggaaagatc attgacgtgg aactacacac gaagtgtaat tagtggggga    660
 aaaaatattt tttaaacaaa ggatataacc atatttagtt gtacagtaag agaaatttat    720
 ctgtgcatag agcataaagt taattttttc aagcatttaa atacatcttt tgtaaggttt    780
 tttaataaag gcagattgag tcaagtttat taaaacttta catggagggg aagaatatgc    840
 taatttgaca tttgagaaaa gtttaaatgc gagcgtttgt tttcacagct tagggattgg    900
 tgggtgaggt ctgtgtgcgt tattttcatg ttcccaaact gtgagcttta tttcatgtta    960
 tttttggtgg atgttgactt agttcatgaa tgttgtcact tctaaatgtg gacagttggg   1020
 ctgcaggatg caactcaacc tcttttggat cctagagacc cctgccaagc ccccatcagt   1080
 ccta                                                                1084



      <210> 2180
      <211> 406
      <212> DNA
      <213> Homo sapiens


      <400> 2180
 aagcttcact tcaacttcac tacttctgta gtctcatctt gagtaaaaga gaacccagcc     60
 aactatgaag ttccttgtct ttgccttcat cttggctctc atggtttcca tgattggagc    120
 tgattcatct gaagaggtga gtcattttca ttcactggaa aacttgtttt cagttttgtc    180
 ctccctacat ttgtattgaa ttattaaact tttcttcatt tttcacagaa atttttgcgt    240
 agaattggaa gattcggtgt aagtgttctc tgataatgct gtgtagtcca aataaattgt    300
 gttctctgat tacttattct tctagaagaa ccaatactta tttctcaaat atatgtagta    360
 gttgcaaaag tgtgctttgt tttcctctat ttatgataca caggta                   406



      <210> 2181
      <211> 940
      <212> DNA
      <213> Homo sapiens


      <400> 2181
 accttattca ataagtattg tctccacagg cccctctgct gacagtgtat acacaaaagt     60
 gaggctcctt gaaggggaga ctctgtctgt gcagtgctcc tataagggct acaaaaaccg    120
 cgtggagggc aaggtttggt gcaaaatcag gaagaagaag tgtgagcctg gctttgcccg    180
 agtctgggtg aaagggcccc gctacttgct gcaggacgat gcccaggcca aggtggtcaa    240
 catcaccatg gtggccctca agctccagga ctcaggccga tactggtgca tgcgcaacac    300
 ctctgggatc ctgtacccct tgatgggctt ccagctggat gtgtctccag ctccccaaac    360
 tgagaggaac attcctttca cacatctgga caacatcctc aagagtggaa ctgtcacaac    420
 tggccaagcc cctacctcag gccctgatgc cccttttacc actggtgtga tggtgttcac    480
 cccaggactc atcaccttgc ctaggctctt agcctccacc agacctgcct ccaagacagg    540
 ctacagcttc actgctacca gcaccaccag ccagggaccc aggaggacca tggggtccca    600
 gacagtgacc gcgtctccca gcaatgccag ggactcctct gctggcccag aatccatctc    660
 cactaagtct ggggacctca gcaccagatc gcccaccaca gggctctgcc tcaccagcag    720
 atctctcctc aacagactac cctccatgcc ctccatcagg caccaggatg tttactccac    780
 tgtgcttggg gtggtgctga ccctcctggt gctgatgctg atcatggtct atgggttttg    840
 gaagaagaga cacatggcaa gctacagcat gtgcagcgat ccttctacac gtgacccacc    900
 tggaagacca gagccctatg tggaagtcta cttgatctga                          940



      <210> 2182
      <211> 429
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> misc_feature
      <222> (1)...(429)
      <223> n = a,t,c or g


      <400> 2182
 ttgatcgggt aagcgaacag accatttcgn gcttggggga gaggctagtg gtaacaggcc     60
 ttgcatgatg gatgggtatg gggagagggg caggacgttc anccctggga ttctggccga    120
 ccctcgcctt tcttctctgc agcttccccg cagccacctc cccgtgcaag atcctcaagt    180
 gcaactctga gttctggagc gccacgtcgg gcagccacgc cccagcctca gacgacaccc    240
 ccgagttctg tgcagccttg cgcagctacg ccctgtgcac gcggcggacg gcccgcacct    300
 gccggggtga cctggcctac cactcggccg tccatggcat agaggacctc atgagccagc    360
 acaactgctt caaggatggc cccaccttgc agacacgcct gcgcacgctt tcaccggccg    420
 gagacagcg                                                            429



      <210> 2183
      <211> 2622
      <212> DNA
      <213> Homo sapiens


      <400> 2183
 atatcttgta accaccatac gccaagcttg gcacgagggc ctcactgtcc ctagtagttg     60
 ggattacagg cacatgccac catgcccagc taaattttta atatttttgt agagatgggg    120
 tcttgctgtg ttacctgggc tagttatgtg agtttctata ttagacatag tctcaagttt    180
 caggtagggt ttaaagtaga gacactggtc agtatttctt ttttgggggg aactaggaga    240
 gcaggagtag aagtgagatg ttaagatctt atggcactaa agacttacta ttctgttcct    300
 acatactctg ttaggatcag atagatgtta tagaaatgcc ttttgtttct cctgcccttc    360
 ttgatgtcac agttttttgt acttccagct gtctaaaggc atgaatctcc tcttggagca    420
 ttctcccaga cccttcttta gaagagtcta tactaagttc ttggtgccct cttcggcagc    480
 caagggtgaa ggccccatag aggagaggat ccaaaggagc attgaggagg cccaagagga    540
 aaaggatgtg gctcaggctg ggagggactt cagttagcat ggtgggggag aaccagtacc    600
 acatacccag taggtaataa ggtgtccagc agaggatgaa ggtcagcaag ataagcaggg    660
 ccagtctcag ggcccggaga cgaacacggg gacaattgtc aaaggagcgg gggagggcaa    720
 attcaccagc aggggctagg aatttagaaa atatactgta attcagacac tcagcttctg    780
 atctgagtat agggtgaatt gatggagggg catagctagt gagacagagc tcgcctccta    840
 caaggaggag aatgttgcaa accgttttcc ccttcccaac ctgggactat atgatttctt    900
 acccccaggg attatgatag aaatatgaag ccaccaagtc tagacttgat ggtgttcaag    960
 aataaataat actgattgcc tccctagtcc ttgtccagct aactcagctg tttataattg   1020
 aagggattca acaaaattat ctctagcatc aggtgctaga catggttaga atctcaccat   1080
 ggtttagtga ctggtagata gctattaggt aggtagataa ataaatgatg ctagaggcaa   1140
 caggtctagg gttaaggatt aaggcctggg aattggagtc tcaccatggc tccccttcct   1200
 tgtctggggc ctggacacac tgaggacaat gcggctatag cagatggcca tggcagtcag   1260
 tggcagcaga aagaggcagc agaaggtgaa gaggttatag gtggtctctt gccattgagc   1320
 cttgaagctg cctttggtga cacactgagt gaaagggact gggccagctc agtggaccgt   1380
 gtggaacagg aacagctgga gtggagttga ggactattag aactggttcc cctcaccacc   1440
 caacctaccc acctatgtca tactgtctcc tcccaattca tccttaattc caagtgaagc   1500
 agcacagtgc tgagaaacag ttcatccatg gtgccatgtt aaagaagttg gaaatatatc   1560
 ttgaaaatcc tatcttcctt ttaggcttga atatgatgct gaacagtaag tttgttaaat   1620
 cttggaactt aaaacaatcc tgctttctca agtactattc taacattgcg ctttataagg   1680
 gatgatattt ctaccacctc actcatattt ttagctgaaa tgattttcct ggtatgtctg   1740
 ttattttgtg gaaaaagaaa tattgtgtaa aatgggtgct gccaaaattc caggccattt   1800
 tgcagggact ctgaagtgac ctttagtagt aatagtctta tgtgcagtaa ctataatggt   1860
 aaagaatgtt aaataataaa atttaacatt ttccaaatgc tattgggctg cccctccccc   1920
 tttttgttaa attgctgggt tttccaactg aatcagtaaa aactatttct gtttagagct   1980
 acaaggttaa agtgcctgct ttccagtaat ggagattgag tcactattaa tttgataaaa   2040
 ggtaagctca gtaggcatca gattcctaga tacaaggcat ttgggaaagt gattttagca   2100
 gacatgaggg acatttagga aagatgaata gtttcagcct aagagaattt tgtgaactgt   2160
 ttggagttac gatcaggcta ctctgagcta gttgggaaat ggtctttcct cttcccatct   2220
 cttgcattca tatatttcta agtttttttt ttttgttttt gtttttgtgc tctgcctaaa   2280
 aagggcttga aaattgtgag gagtttaaaa atagtcaaag ctggctgggc cgcgggggct   2340
 cacgcctgta atccccagca ctttgggagg ctgaggcggg cggatcacga ggttaggaga   2400
 tggagaccat cctggctaac acagtgaaac cctgtctgta ctaaagatac aaaaaactgg   2460
 ccgggcgtgg tggtgggtgc ctgtagtccc agctacttgg gaactcggga ggctgaggca   2520
 ggagaatgac ctgaacccgg ggggcggagc ttgcagtggg cagagattgc gccattgcac   2580
 tccagcctgg gcgacagagt aagactgtct ccaaaaaaaa aa                      2622



      <210> 2184
      <211> 437
      <212> DNA
      <213> Homo sapiens


      <400> 2184
 gcccggcttg gggtcgactt tcaggggccg ccgagatgtg tcaggctcct gggagcggga     60
 ccagcaggtt gaggcggcgc agcgggccct ggtggaggtg ctggggcctt acgagcctct    120
 gctgagtcgg gtgcaggcag ccctggtgtg ggagcggcca gctaggagcg ctctgtggtg    180
 cctggggctg aacgcggctt tctggttttt tgccctgaca tctcttcgtc ttgtgttttt    240
 acttgcattt ggcttgatga tcattgtgtg tattgatcaa tggaagaaca aaatctggcc    300
 tgaaataaaa gtgccaagac ccgacgcatt agacaatgag agctggggct ttgtgcaccc    360
 tcggttgctc agcgtgcccg agctctgcca ccatgtagct gaagtctggg ttagtgggac    420
 cattttcata aggaatg                                                   437



      <210> 2185
      <211> 3639
      <212> DNA
      <213> Homo sapiens


      <400> 2185
 atgagccacc gcgcccagct gaggactctc cagggagttg tatcttatga ttccagtagt     60
 ggaaagaaca aaatcaaaac actgtatggc gaaatcctca acgggaagga cctggaattc    120
 acatccttcg agatatcatc tgtacctcag cactgttgtg acccgtattc cagcgtggta    180
 ttccttgaag tagatgtgga tgactgtcag gatgttgctt cagagtgtga agccgaatgc    240
 atgccaacat tccagtgttt taagaaggga caaaaggctc actttcagat gccctccagg    300
 tggccttgtc ctggccactg ccacatctgc accgtggaga aaccccagct gaggtatagg    360
 gctggcccag gtcacacagt gaggccgtgt gaggaagagc accggtctgc tctgggcctg    420
 gtcctcgcct ggtggctggg agtgttcatc tgtagcttca tggtggctgc ccccatcttc    480
 ggctacctgg gcgaccgctt caacaggaag gtgattctca gctgcggcat tttcttctgg    540
 tcggccgtca ccttctccag ctccttcatt ccccagcagt cccctgcaga gagctgtgac    600
 ctgctgggtg acatccagac ctgcatcagg aaaagtctgg gagagaagcc ccgccggagc    660
 cgcaccaaga ccatcgaccc ccaggaaccc ccgtgggtag aggtgctggt ggagatcttg    720
 ctggccctgt tggcccagcc cagccacctc atgcgccagg tggcccggag cgtgtttggc    780
 cacatctgct cccacctgac cccgcgtgcc ctgcagctaa ttctggatgt gctgaacccc    840
 gagaccagtg aggatgagaa tgaccgtgtg gtggtgacgg acgattctga tgagcgccgg    900
 ctgaagggtg cagaggacaa gagcgaggaa ggtgaggaca acagaagctc agagagtgaa    960
 gaggagagcg agggggagga gagcgaggag gaggagcgcg acggggacgt ggatcagggc   1020
 ttccgggaac agctgatgac cgtgctgcag gctgggaagg cgctgggtgg agaggacagt   1080
 gagaacgagg aggagctggg ggatgaggcc atgatggccc tggaccagag cctcgccagc   1140
 ctctttgccg agcagaagct gcgtatccag gcccggcgag acgagaagaa caagctgcag   1200
 aaggagaagg ctctgcggcg cgacttccag atccgggtgc tggacctggt ggaggtgcta   1260
 gtgaccaagc agcccgagaa tgccctggtc ctggagctgc tggagccgct gctgagcatc   1320
 atccggcgca gcctgcgcag cagcagctcc aaacaggagc aggaccttct gcacaagacg   1380
 gcgcgcatct tcacgcacca cctgtgccgt gcccggcgct actgccacga cttgggtgag   1440
 cgcgcagggg ccctgcacgc ccaggtggag cggttggtgc agcaggctgg ccgccagccc   1500
 gactccccca ccgccctcta ccacttcaac gcctctctct acctgctccg ggtcttgaag   1560
 ggcaacactg ctgagggctg cgtgcatgag acacaggaga agcagaaagc tggcactgac   1620
 cccagccaca tgcccacggg cccgcaggct gccagctgct tggacttgaa cctggtgacc   1680
 cgggtgtact cgacagcact gagctccttc ctgaccaagc gcaacagccc cctcacagtt   1740
 cccatgttcc tcagcctctt ctcccggcac ccggtgctct gtcagagcct gctccccatc   1800
 ctggtccagc atatcacggg cccggtgcgg ccccgtcatc aggcctgcct gctgctccag   1860
 aagaccctgt ccatgcggga ggtgaggtcg tgctttgagg accccgagtg gaagcagctg   1920
 atgggccagg tcctagcaaa ggtcaccgag aacttgcgcg tgctggggga ggcgcagacc   1980
 aaggcgcagc atcagcaggc actgtcctcc ctggagctgc tcaacgttct cttcaggacc   2040
 tgcaaacatg agaagctgac cttggacctg acggtgctcc tgggtgtgct gcatagggca   2100
 acagtaagag cctacagcag ggggcacact ccaccggcta tagacgcctg cacgagctat   2160
 actggcaggc catgaaaacc ctgggagctc agcgccccat gatggagaat aacgatgcct   2220
 aagagatacc cattgccacc catagcccca atagtaggaa gcggaagaaa aagggattct   2280
 tgccagagac gaagaagcgc aagaaacgca agtcagagga tggcacgcca gcggaggatg   2340
 gcacacctgc agccaccggc gggagccagc cccccaatgc atgggcagga agaagaggaa   2400
 caggacaaag tgttaaggtc ccagcccagg caaacgggaa cgccaaccac caagagtcca   2460
 gcccctggcg cccccacccg gaagccccag cacccctgcc aaatccccaa aactgcagga   2520
 agaaaaccag aaagccgtcc caggtgaatg gagctcccgg gtcccccacg gaacctgcag   2580
 gccaaaagca gcatcagaag gctcttccca aaaagggggt cttgggcaaa tcaccactgt   2640
 ccgcgctggc acggaaaaag gcaaggctgt ctttggtcat caggagtccc agcctgcttc   2700
 agagtggggc caagaagaaa gcacaggtga ggaaggcagg gaagccctga gcacaggtac   2760
 gggcccccct cagcccctgc cttccatctg cctgagacgc ctattttttt tttttttttt   2820
 taaaaccatg attttaatac gcaagctgtt tctaaggcgc tgccactggg gagggtggct   2880
 gttgccgcct gcccgggcat cctgctctgg caagcacagc ctgagccatt ccttgcaggg   2940
 gtcccagggt gcaagagact tccccccccc cggttttggg ctgggaccct ggctccaggg   3000
 ccatgtccag ggctttggtg tttgcctggg ttggtgcagg ttaatgtgct ggctgcaggc   3060
 aggtgtgacc atctttcgtg cctgccacct ctttgccccc atggcttttt ttgctgtgag   3120
 ggagccccca gggggtgatt taaataggtt tagtttcttc atttacaaga ggaatatatt   3180
 tggcttctct cttaagactc tgagattcac aatcagcagc tctaaaaaat aaaggagcag   3240
 tttggcttcc ggaaggaaga gcgaggcaac actcggacct ggttcttgta caacaagaaa   3300
 acatcgctgg gcgccccgct gaggctggta gtgggggtgg aggctggtct ttggaggatg   3360
 ccacccccac cccatcctct tttcagggcc ctcggggtac cccagaagct tgggtggggt   3420
 gagtattcca cctgtttaca caccactgga aggccacagc caggccagta actacagggg   3480
 caagaaagag cattgtccaa gctggctctt ggggggggtc ccccattggc cacaaaggcc   3540
 tcacccccca ccccatcccc gtaaccagaa accaccttga ttgcagcaga aattcaggca   3600
 gatgggtagc gcaggggggc taaccccccc acaagcggg                          3639



      <210> 2186
      <211> 526
      <212> DNA
      <213> Homo sapiens


      <400> 2186
 gcggccgcgg gctcctcgcg ttgaccttct gcctgttggc cgcgcgcggg gagctgctgt     60
 tgccccagga gacgactgtg gagctgagct gtggagtggg gccactgcaa gtgatcctgg    120
 gcccagagca ggctgcagtg ctaaactgta gcctgggggc tgctgccgct ggacccccca    180
 ccagggtgac ctggagcaag gatggggaca ccctgctgga gcacgaccac ttacacctgc    240
 tgcccaatgg ttccctgtgg ctgtcccagc cactagcacc caatggcagt gacgagtcag    300
 tccctgaggc tgtgggggtc attgaaggca actattcgtg cctagcccac ggccccctcg    360
 gagtgctggc cagccagact gctgtcgtca agcttgccac actcgcagac ttctctctgc    420
 acccggagtc tcagacggtg gaggagaacg ggacagctcg ctttgagtgc cacattgaag    480
 ggctgccagc tcccatcatt acttgggaga aggaccaggt gacatt                   526



      <210> 2187
      <211> 565
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> misc_feature
      <222> (1)...(565)
      <223> n = a,t,c or g


      <400> 2187
 cccacgcgtc cgatgctgtt cgcctccgtg gccctgcgtt atgccttccc ctgccaggtg     60
 tacgcagaga agaaggagaa ttcaccagcc cccccggcac ccatgcagag catctccagc    120
 ggcatcaggg agacagtgag cccccaggac atcgagcagg acgccatcca caacttctcc    180
 cccgcctacc agcactacac gcagcaggcc acgcacgagg cgcccaggcc cggcacccac    240
 cccagcggcg gctccggcgg gagcaggaag agccggagcc tggagaagcg gatgctgatc    300
 ccctcggagg acctcggagg ggggctgntc tgncagngct gtaggcaccc atgctggcca    360
 agcctatggg gaagaacagg ggccacccac ccaccaactc ctgtcatagg ttgagcctct    420
 tctagaagcc caccatggag ggcctcggaa gccacgttcc catactccct acgctcatgg    480
 ggctagggca cctgcatggc ccttgactag cttcttagag gggccctctc aaggttagga    540
 gagtgcacca tggtggtaat cgaag                                          565



      <210> 2188
      <211> 444
      <212> DNA
      <213> Homo sapiens


      <400> 2188
 caccattatt gtgcatctag ttccccggag ggccagcaca gtggccacca gcacccacag     60
 aaccacagtg ccctcaacga tgacacccat gctcgtgaca gacacagagg ctttctggca    120
 gccacagccc tggtttgtgg tggtgttgac agcaactggt gctcttctcc tcttggccct    180
 aggctggctt cttggcaggc tcctccaggg gttggcccag ctgctgcaag cacccagcaa    240
 accagcccag gctttgctgc taaacagcat ccagggaact gagggatcca tcgagggttt    300
 cctggaggca ccgaagatgg agatgtccca ggcacccagc agtgtcatga gtctgcagca    360
 ttttgatggc agaacacaag actcccgtac cggaagagac taccttgtta acacacacac    420
 aggagcccgg cgctggctct gagg                                           444



      <210> 2189
      <211> 958
      <212> DNA
      <213> Homo sapiens


      <400> 2189
 agatattttg cactagttgt ctattttctc attgaaaacc aatatggcat tcttatgtta     60
 aacacaaagt tttataacta aataactcct gaaataggaa taacagagta tactatcttt    120
 ttatttcata aaagtagtca ttttagtgac taagaaatca aaataaaata tcgctctgtt    180
 cgctacaaat gaaattctca aatacaaagc tatgtcctaa gataattctg atttgagatt    240
 tttcaagcaa ttgaattttc ataggtattc attagatatt tatattcaac gtctagtata    300
 agaatatgac aatgcccccc acttactaga ggtatgacct tggatcagtt gcttaaactt    360
 tctccagctc agtttcttta tttgtaagat gaggctagta actgtttctc cttgataggg    420
 ttattataag atcatatgag taaaatacat agcaccgtat ttagaatata gtaaacaaac    480
 aattattgta ttctataact gatatttctt tacatatccc ccaactccca tttttaaatg    540
 cctgtatgtg tattacaact taataattgt ttgggtgcct actgtgtaat cagcagcttt    600
 tttacaaata catttcttct ccttaatgca gtcattaatt tcctgtattt aggatatctt    660
 ggattcagtg agtccccaca taaataatta aggtcaaaaa taaggagata gccttcccat    720
 ttgccatgac tactttattt tttctctttg ctctcatcac taacatatta cgttttttac    780
 ttactgattt cagtatggct ctcttgctag aaaagaagct ccacaaaggg cgggcttttt    840
 gacagtacct ggcacgtagt aaatgacaaa tatttgttat atatatgaat gaaatattgg    900
 catcaaactt taaaatttct ccttaaaaat tggggtagcc ctttttttgg cactttca      958



      <210> 2190
      <211> 705
      <212> DNA
      <213> Homo sapiens


      <400> 2190
 gaaattcttc actaaggggt ttcaaaccac agtgcaactt cagaccacaa tcctgtacaa     60
 gagccagctt gtgatttaca aattctccag ggaaagtgac aggttggaga taggcatggg    120
 gttttgttgt tgttcttgtt gactcctgca ttctgcatgg caggacctag gcctctttac    180
 ctgtacattg caggtataac cctttcatga cacaggttca tcagagggtt ttagtctgca    240
 ctgtggcaga ccttggcttt atctcttgcc ttgacctcct acattatcaa caaagtgaga    300
 gtttaagatc tcctgggcag gagatttcag aagccagcct aagcttttgg gccttcctca    360
 cctcctaggg cctttgtgtc aggttctttt gggttcttca tattccttac ctccctttca    420
 gtgatgttat tataaagatt ttgatttatt cagcatttca cggtctgttt agtgaggtgc    480
 ttaacattga acttctgaaa tgaagggcat atagctaggg gaagcttacc tttggtttgc    540
 cctgaaaagt tatggtttac atctggtttc ccaaacaaat aatagctccc cttttacaca    600
 cgcacaaaaa ttggttcatt tgatgataaa cttgagggcc tcctacccat agcccttggg    660
 atttcatttt tgaacacagc aggggagggg atcaccaagg tgttt                    705



      <210> 2191
      <211> 392
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> misc_feature
      <222> (1)...(392)
      <223> n = a,t,c or g


      <400> 2191
 aatacacctg tctcatcctg tgacttagaa agcctcaacc ccctgggaat gcagtccagc     60
 aggttgcagc ctcagtttac ccagccccgg ttcaagatgg agtcactctg gtttgaaggc    120
 ctctgattca cctggagaca cattccggct gtaccaggcc tccaccagga aagctcccat    180
 gataaccaca attacggcag ccagacccag tcgtacgaag ttacccaggg agtagttgct    240
 cgatgtggta cctgggggaa ctgtcaccaa tatctcaagc tgatcactgg gttctgaggc    300
 ccagaaggga gactttgtct ggtagtacat gcagctgtag ttcccagcat cgtcggctgt    360
 cacgtccacc agagagaagt ctatctcctt tn                                  392



      <210> 2192
      <211> 985
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> misc_feature
      <222> (1)...(985)
      <223> n = a,t,c or g


      <400> 2192
 ccgaattcgg ccgagatcgt gtccagcctg aaatcagctt taattgtccc ccaggtaaat     60
 aaacacctgg tgaaagtcac ctttggaaaa ttaatgcttt tgaaaataat ccatgagtct    120
 aagtatgact ttcaaatcac cttcaccgtg tgtctgggaa catttcaggt tgatttccta    180
 catcacatca ctcctcttct gcttattgta ttcccactta ctagacgtca ggtgttggtt    240
 tattaggaga cattgctgtg catgtcacac agccagttgg caccacattt ttggctcctt    300
 ctgttgaatc tctttctagt tggctggcaa gttaaatctg ttcattgaga agggagcgtg    360
 tgcatatttg tgcttgttta tgtatgtatt actggcaggg gatgagacag aagcaaaagt    420
 tgggtcagtt aaatacaatc gtctctcttc tactttgtag tttttggaga tatttttcca    480
 tgccattttg taacagatga tatcctgggt tttattattc agtcttttgt gtctgtcagt    540
 gaattatttg ttagcctttg agcctacata tgtagcattt tattatggga ataataatat    600
 agaagcaatg tatgtattta catatccatg tctcagattg ttagagactg gtgaccagag    660
 taatgatatc catgagttag cttacatgag aatttctggg gacagtagtg ggttcttact    720
 gggggcccag ccaatgggtt aggtacttta tgtatattaa cttatttaat tctcatagca    780
 acactacgaa gtagctgcta ctattatctc cattttccag gtgaggaagc agacatagag    840
 aggctacata acttgtttaa ggtcacacca actaataagc aacgatctta cttagtctaa    900
 attatggaat agtatgagac actcctgaaa tttgagatgc ttaatacagc agaggcttat    960
 ttctcactca agggatacng tgcgg                                          985



      <210> 2193
      <211> 1421
      <212> DNA
      <213> Homo sapiens


      <400> 2193
 ggcaatttcc ggcgcctccc tcacgcccgc cctccttgcc gcccagccgg tccaggcctc     60
 tggcgaacat ggcgcttgtc ccctgccagg tgctgcggat ggcaatcctg ctgtcctact    120
 gctctatcct gtgtaactac aaggccatcg aaatgccctc acaccagacc tacggaggga    180
 gctggaaatt cctgacgttc attgatctgg ttatccaggc tgtctttttt ggcatctgtg    240
 tgctgactga tctttccagt cttctgactc gaggaagtgg gaaccaggag caagagaggc    300
 agctcaagaa gctcatctct ctccgggact ggatgttagc tgtgttggcc tttcctgttg    360
 gggtttttgt tgtagcagtg ttctggatca tttatgccta tgacagagag atgatatacc    420
 cgaagctgct ggataatttt atcccagggt ggctgaatca cggaatgcac acgacggttc    480
 tgccctttat attaatcgag atgaggacat cgcaccatca gtatcccagc aggagcagcg    540
 gacttaccgc catatgtacc ttctctgttg gctatatatt atgggtgtgc tgggtgcatc    600
 atgtaactgg catgtgggtg taccctttcc tggaacacat tggcccagga gccagaatca    660
 tcttctttgg gtctacaacc atcttaatga acttcctgta cctgctggga gaagttctga    720
 acaactatat ctgggataca cagaaaagta tggaagaaga gaaagaaaag cctaaattgg    780
 aatgagatcc aagtctaaac gcaagagcta gattgagccg ccattgaaga ctccttcccc    840
 tcgggcattg gcagtggggg agaaaaggct tcaaaggaac ttggtggcat cagcaccccc    900
 ctcccccaat gaggacacct tttatatata aatatgtata aacatagaat acagttgttt    960
 ccaaaagaac tcaccctcac tgtgtgttaa agaattcttc ccaaagtcat tactgataat   1020
 aacatttttt ccttttctag ttttaaaacc agaattggac cttggatttt tattttggca   1080
 attgtaactc catctaatca agaaagaata aaagtttatt gcacttcttt ttgagaaata   1140
 tgttaaagtc aaaggggcat atatagagta aggcttttgt gtatttaatc ctaaaggtgg   1200
 ctgtaatcat gaacctaggc caccatgggg acctgagagg gaaggggaca gatgtttctc   1260
 attgcataat gtcacagttg cctcaaatga gcaccatttg taataatgat gtcaatttca   1320
 tgaaaagcct gagtgtattg catctcttga tttaatcatg tgaaactttt cctagatgca   1380
 aatgctgact aataaagaca aagccaccct gaaaaaaaaa a                       1421



      <210> 2194
      <211> 2228
      <212> DNA
      <213> Homo sapiens


      <400> 2194
 tttttttttt ttcctgaaat gtaaattgtt tttaatatat ttaagagcac acagaagtct     60
 tgatttataa aaaaataaat atataacatg acaaatttac tgatgatcct ggagctctga    120
 ggtcaaactc tttaaatgat cagtgaaaac ataaaacatc catgatctgt taacacacac    180
 aggagcatat tccagttgta aaaaacaaat tccttgaagg ctcagaacga acaaaaatca    240
 gtctttatgg cagaaagcac atccaaagct aggcaatgaa gttcagcctg ggccacgtga    300
 acctttcacc agccagccta taacctatgg agccaggaca ggaaagcatg atccttcagc    360
 tcatgacgcc acccaggctt ccagacaact gcagaatgaa agagtccctc agaggctccc    420
 cagcccctgc tgccatcata aagcacggga gggattgttt tgtccttagc ggctctgtcc    480
 taaatttgag agcaggagac tgagaaggtt atgctcatta aatattgtca ttgtaacacg    540
 gaatggaaat catgatcctt gcccatgggc actgagctga aagaaagagg aacctcacat    600
 gaggctttcc tagagaccag gatgttgggt gagtgggcgt gcacttctca agtgggcaag    660
 gaagaactgc ttttctccag ctgacatgct ctcaggggtg aagaagttta gcttaaaata    720
 cctgatggcg ctgcataaac tggggatttg ggaactgagt ttttagctct gtgacacaca    780
 acataaaaaa caaaaatcca gtctcattag ctaaattcgg attaaaatct gaaatgtttt    840
 tatggagttg ccaacaggct ggaatgtacc tgatacaatt taatctgctt ttatttcttt    900
 ggctgtcttc caaaccactt tcttcctgta attcttaagt tggctagttc tccttcctca    960
 gaaaaattac ccctaagaat cttcctaata gtgagggtgt acttccgaat agaagagtcc   1020
 ttcggctgaa atggcatctc caaggcctac agttcgaatg gggtctttac acaccaatac   1080
 tggtgtgaag tggaaggata ttccctctct gtgccattct actactggct tgtttgggtt   1140
 taatacaatc ctggagcctg cctccgaatg ggaagtcatg aactcttggg gtgccctcag   1200
 agacactcgg ctggtgtcta tggtttctgt ggcgcaggcc tgtgtcccag ccacacgagc   1260
 tcctgcagcc acggctgcca gctggttggc ccagtgtcca tccacagttg ccaggatgtg   1320
 gtagaccagc gtgtggaaat ggatcctggt gagatccgag gctctgcttt tactcctccc   1380
 atgttctttc aagatccaga agaggatgtc actgaccatg cccacatcag gaacaccgtt   1440
 ccaggaagag agagaagagt gaggtccaga ggctgactgg gtgagaaata acagctcctg   1500
 ttcattcagc ccaagggaag tcaccgcggg aaagacctgc tgaaggaaca atgctgctca   1560
 tgagctccct gttagtcata ctggcccagc tctaggtgaa actggaatac cagtggggat   1620
 gtcagaaatg gaggttacaa cctccaagag tctcttcctc tggagctcct tgctttgtcc   1680
 ctccatcatg tgcaatccag agaggccccc caggtctggc tgaaactcct ccaggctaga   1740
 cacaaacacc tccagcatat tcatggcccc gttggagagg tcgtgagaga agatgaatcg   1800
 gttggcatgg ggagctttta actggcccca ctcctcccct gcttgatact ctaaaatgag   1860
 gtggaactca tccacttcct gcaatgactc tggtggaaca aagacattgt catcaagaag   1920
 ctcatgtagc tttggaccaa ctggaccgca aagaagaacc tttaaatctg agttggctgc   1980
 aaatttctgt ccaattaaag ctgcatttcc tcctacatag tgctgggctc ctgggaactc   2040
 tgacgcaacc tgggcaatgt cgtgaaaagt ttccttatca ctgaagaagc gctcagcagc   2100
 tgctcccttc cccatgaagt gaatgaaggc ttcttccaga tcattccttg aatgcagaat   2160
 gctgtgatct ttcccattcc caggactaag gccaagtgcc tgcaagagct tcacccctga   2220
 ggaattca                                                            2228



      <210> 2195
      <211> 1177
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> misc_feature
      <222> (1)...(1177)
      <223> n = a,t,c or g


      <400> 2195
 cccacgcgtc cgctcctctg ggggtcaaga ggaccccgcc agccagcagt gggcacgacc     60
 gcgcttcaca cagccctcca agatgaggcg ccgggtgatc gcacggcccg tgggtagctc    120
 cgtgcggctc aagtgcgtgg ccagcgggca ccctcggccc gacatcacgt ggatgaagga    180
 cgaccaggcc ttgacgcgcc cagaggccgc tgagcccagg aagaagaagt ggacactgag    240
 cctgaagaac ctgcggccgg aggacagcgg caaatacacc tgccgcgtgt cgaaccgcgc    300
 gggcgccatc aacgccacct acaaggtgga tgtgatccag cggacccgtt ccaagcccgt    360
 gctcacaggc acgcaccccg tgaacacgac ggtggacttc ggggggacca cgtccttcca    420
 gtgcaaggtg cgcagcgacg tgaagccggt gatccagtgg ctgaagcgcg tggagtacgg    480
 cgccgagggc cgccacaact ccaccatcga tgtgggcggc cagaagtttg tggtgctgcc    540
 cacgggtgac gtgtggtcgc ggcccgacgg ctcctacctc aataagctgc tcatcacccg    600
 tgcccgccag gacgatgcgg gcatgtacat ctgccttggc gccaacacca tgggctacag    660
 cttccgcagc gccttcctca ccgtgctgcc agacccaaaa ccgccagggc cacctgtggc    720
 ctcctcgtcc tcggccacta gcctgccgtg gcccgtggtc atcggcatcc cagccggcgc    780
 tgtcttcatc ctgggcaccc tgctcctgtg gctttgccag gcccagaaga agccgtgcac    840
 ccccgcgcct gcccctcccc tgcctgggca ccgcccgccg gggacggccc gcgaccgcag    900
 cggagacaag gaccttccct cgttggccgc cctcagcgct ggccctggtg tggggctgtg    960
 tgaggagcat gggtctccgg cagcccccca gcacttactg ggcccaggcc cagttgctgg   1020
 ccctaagttg taccccaaac tctacacagg acattccaca ccacacacat acacacaccc   1080
 cccaccctcc tgccaattaa acagtagcca ttccccnaaa atnnnnnnnn nnnnnnncnn   1140
 nnnnnnnnnn nnnnnctcgg cccccgccta ttcaccg                            1177



      <210> 2196
      <211> 686
      <212> DNA
      <213> Homo sapiens


      <400> 2196
 caagggaggg ctctgtgcca gccccgatga ggacgctgct gaccatcttg actgtgggat     60
 ccctggctgc tcacgcccct gaggacccct cggatctgct ccagcacgtg aaattccagt    120
 ccagcaactt tgaaaacatc ctgacgtggg acagcgggcc agagggcacc ccagacacgg    180
 tctacagcat cgagtataag acgtacggag agagggactg ggtggcaaag aagggctgtc    240
 agcggatcac ccggaagtcc tgcaacctga cggtggagac gggcaacctc acggagctct    300
 actatgccag ggtcaccgct gtcagtgcgg gaggccggtc agccaccaag atgactgaca    360
 ggttcagctc tctgcagcac actaccctca agccacctga tgtgacctgt atctccaaag    420
 tgagatcgat tcagatgatt gttcatccta cccccacgcc aatccgtgca ggcgatggcc    480
 accggctaac cctggaagac atcttccatg acctgttcta ccacttagag ctccaggtca    540
 accgcaccta ccaaatggtg agtgtatgtt gcaccctggt ctttctctgc ctaggaagcc    600
 tcttccctcc caattagatc tgagttgctt taagaaaaaa aggggacatg ttatgtaaat    660
 tagcatttcc cacaacatgt cccttg                                         686



      <210> 2197
      <211> 434
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> misc_feature
      <222> (1)...(434)
      <223> n = a,t,c or g


      <400> 2197
 gtacactacc cggntcggaa ttaccgggtc gacgatttcg ttctgtgacc aacctctgcc     60
 acgaagcctg ggtcccagca gtttcaagtt tctgttttgg aagggtggct ttcgcggggt    120
 accccatctt ccccgggact gccttgataa tcccctgctc gggtgaaagg ggcaggcgtg    180
 ggctgcccat ttgttccttg ggggatgctg ctgctgcctc ccaaaaccct aatgcctgtg    240
 cccattctct ggactcaggc tgggctgcca gggccccctg gactggtcct acctgcagct    300
 ggcagcttcg ggggccgcca cagcgtattt cagctccttc agtgcctatt gcgtcttccg    360
 gatcctgatg ggcatgacct tctctggcat catcctcaac tccgtctccc tggggagtcc    420
 agtcgaggag aggc                                                      434



      <210> 2198
      <211> 373
      <212> DNA
      <213> Homo sapiens


      <400> 2198
 cccaagtccc tctgccgtga gtcccactgg aagtgcctcc tgctctcgct gctcatgtac     60
 ggctgcctgg gggcagtggc ctggtgccac gtcaccacag tgacgcgcct caccttcagc    120
 agcgcctacc agggcaacag cctcatgtac catgacagcc cctgctccaa cggctatgtc    180
 tacatccccc tggccttcct gctcatgttg tacgccgtct acctggtgga gtgttggcac    240
 tgccaagccc gccatgagct gcagcaccgt gttgatgtga gcagtgtgcg ggaacgtgtg    300
 ggccgcatgc agcaagccac gccctgcatc tggtggaagg aacatcagct accactatgt    360
 ccgccgatgt att                                                       373



      <210> 2199
      <211> 1749
      <212> DNA
      <213> Homo sapiens


      <400> 2199
 caatttctga atagcaactg gaatattcaa ccaacaatgg tcatggtcag ttttgtattt     60
 tttccttaac ttatatactt cattctttcc aactatttta aagctaaatc ttttttaaaa    120
 aagttttaaa aataagtcac aggcaaatca tgaagagttg ggtttatttc aacagtaaat    180
 ctgaaactct tgccttaagc aagagtacta cagtaattat atcaggaata gacaatttcc    240
 tacactgtca aatatataaa agttcctttt gcactttctt caacactgat caacaagcag    300
 attcagtcca catttgcttt gatctaacta ctgagttaac ccaagcttct tcttcagaga    360
 ctctggcatc tcgggtggag gagggcgagg aagtctgaag tagaccttca cggagtcata    420
 gataaaccac tgtagtgcag tcagggtacc aatcatgatg atacgggcaa acagtccctt    480
 ccatacacct ttaaatccaa gtctcttgag gaccagagaa gcactgctac ctttttcttt    540
 attcaacaca gataccacag aatcagcagg gtgagaaaca attgcacaaa agactccagc    600
 tatgtaacct gctacaaatg ttacaaccag ctgctctggc tttgaacatt cactgcgggg    660
 cttaggaacc acaaacttgt acagtgcttc aacagtacgt tcaaagcagg cgaacttcat    720
 catggtgtat ggtatctgtc tcatccagag aggagcaacc cccttgtaga atgcttttag    780
 gccttcttcc ttatacattt tgggagctgc atccctcaaa gtgttggcat aacctggctg    840
 ggtttgaatt cgaaccttag cagcttccat aggagccagg gcaatgtcag caaagaattc    900
 agcactggca gaggcagcca aatatagtga tgtgcgccag agataagtat tctcctctcc    960
 aagcatattg cctatacaag cctttaaaga cttcataaaa gccaaacttg cagagtccct   1020
 gcatggagta gccaaggaaa gtcggagccc atcctttagc caaaccacga acaccatcct   1080
 ctttaagtgt aactgagaat ccgttaaata tgcccttgta cttttggggg tccacctgca   1140
 tacggcattt cactaaatcc aggggaacca cagcagtgtg tgtcagacca caacttaaga   1200
 ccccaccaaa gccacacagt gcataatact tcgcggagcc aaattcacaa ctgtactctg   1260
 tagtaagaga agacacacca tgcattttaa tataaaactc atgttactgg tcataaactt   1320
 acctcctgga cagttaggtt tccacacagc ttgttagatg actatatctt ataacttaac   1380
 agtcagtcat gcttcaatat gctctagtcc agcatgcaaa acaaacctgc attctgcatt   1440
 taaccagatc tagaggaacc aatgctgtat gtgttgtgcc acagctaata attcctccaa   1500
 gtccacaaag gataaagaat ctgccagatc catagtcaca gctatactgc tcttccacgg   1560
 cggcggctgc caggttgcga gggcggcggg gctggcccgt gggccctggg gagctgctgc   1620
 ggaggtcccc gagaccatcg tgcaccagct gcagatgtgg cgtgttgaag gggttcgccc   1680
 gcgccaggtg cgccacggac gagaacatct tttccctaag atggcgatca cacaaccact   1740
 cccttggaa                                                           1749



      <210> 2200
      <211> 1064
      <212> DNA
      <213> Homo sapiens


      <400> 2200
 atcgtggtgt atgtgggcgt ctcctcagcc ggcagcttca ctgtgccctg cggttgatgt     60
 ccaaggtttt gactgtgtgg gtttgtgtct ttccggcagg tgtctcctct gtgacttccc    120
 tgatgtccct ggcttgggtg ctagcctcct atcacaagct gctgcgggac tccagggacg    180
 acaagaagag catgagctac agaggggcca tcatccaggt cttctggcgc ctcttcacca    240
 tctcatcccg agtgatctct tttgccctct ttgcttccat cttccagctc tattttggga    300
 tcttcgtggt ggttcactgg tgcgccatgg ccttctggat catccatggc ggaacagact    360
 tctgcatgtc caagtgggag gagatcctct tcaacatggt ggtagggatc gtgtacattt    420
 tctgctggtt taacgtcaag gaagggcgga ctcgatatcg aatgtttgca tattatacga    480
 tagtcttgac cgagaatgct gccttgacgt tcctttggta tttttacaga gacccggaga    540
 ccactgactc ctatgcggtg ccagcactgt gttgtgtctt tattagcttt gtggctggga    600
 tcgcaatgat gctcttatac tatggcgtgc tgcatcccac aggaccacga gctaagatcc    660
 ttgccagctc ctgttgtgcc gagctgctct ggggcatccc tttgcccccc gatgttgagc    720
 ccatggcgcc tgagatccct gggtaccggg ggacccaggt tacgcccacc agagccgtaa    780
 cggaacaaca ggaggatctc acggctgaca cttgcttgcc tgttttccaa gtgagaccca    840
 tggggccccc taccccgttg gggcgtcctt acctcccaga agggcccctc attaagattg    900
 acatgccaag aaagcgatac ccagcttggg atgctcattt tgtagacagg aggctgagaa    960
 ggactattaa cattctacaa tatgtcaccc ccaccgcagt aggcattcga tatcgagacg   1020
 gaccactcct ctatgagttg ctacagtatg agtcttcact ctaa                    1064



      <210> 2201
      <211> 426
      <212> DNA
      <213> Homo sapiens


      <400> 2201
 ttggggggac tgaagggtac gtggggcgaa acaaaaccgg ccatggcagc agcggaggag     60
 gaggacgggg gccccgaagg gccaaatcgc gagcggggcg gggcgggcgc gaccaagacc    120
 ctcttgtata ctggaaacca ccttttttct ccccagtggc tggagacacg gccagaacgg    180
 caagagtgtc cagtatgtaa agctgggatc agcagagaga aggttgtagg agaaaaatcc    240
 ctgttaactt tctctctcca cttcctcaga ttaaaaactc cacagatttg ccggcttccc    300
 gtctgacttt ttctgcctcc ctagggattc cagccatttg gtgataccgg gggcttccac    360
 ttctcatttg gtgttggtgc ttttcccttt ggctttttca actccccatc ttactgattt    420
 aattta                                                               426



      <210> 2202
      <211> 1751
      <212> DNA
      <213> Homo sapiens


      <400> 2202
 gtatacattt tcccacaaaa tggttgtaaa gatttaagtt attttaattt aatgttgatt     60
 aagaacccta gatgaaactg gtcagaacct gtaaattact tagtttatat ccactttgag    120
 caggtatcaa atgatttagg atccttaaaa ttacattcta ataattaagt tatgtggaaa    180
 aagtaaggct ggggaagtcg tgattaatag ttttcaaagg gccatttttt aaaatcctct    240
 gggcattttc tttcagctgt ttgttagttt ttgctttatt taaagcatat ttaagttatt    300
 ttaatgtggt ttaggggcaa aatgtgcaga tacttcattt ttgtaagatt gtaatagatg    360
 ctgtttatac taaacatgtc atatctatct atacagtata tattaaaaga aagcttgtac    420
 tgtatcttat ttgatgatat ttattttctc tgccaagctg tatagtaaaa ggaaaataag    480
 tcacatctgg tcattggcat ttgtatcgtc attctgtaaa gacaaaagag tacctatata    540
 agaagctcca cgtagtgcaa atcgacatct ggtaggctgc tcgcccccag gcagcagcta    600
 tgagtctgta attctctgcg tcatcctctt ctttttcttc atttttgctt tttcttcgct    660
 tgagttcttc tctgaaatta tatgcaaaga gttgtggggt cttcatcaca catttttctg    720
 gtatacatca cagaggctcc ttaaaagtgt gaggatggga gagctggcgg ggccgaagga    780
 gtaggggtct atgtctgccc aactctaaca agcctgcccc gtgctttcca aggcgctgcg    840
 cttcagggaa taacattctg agccctcgat ggcagtattt ccttcggaac tgaaatacat    900
 tctgaaccac tttttccacc agcttgaatg gctgctctat cttgggctgt atcaagggag    960
 tgaagtgcac cacgcccacg tccaccttcg ttgtaagcaa acatattatc attctctggt   1020
 ttggggacaa aagcttgtcc tggaattgta aagatgtgtc gaacattgca gaggtactga   1080
 gccataacag agaggcgact acgctgtttg cttcctgtat tggctgcaag tctctctgcc   1140
 acttcctttt gaaaagtcaa agtcatctga gttctgccat aaacaaaagg tccatctcta   1200
 caggaaatat tttcaagcca cttgataatc agtggagttg aaacactaaa aggcagattt   1260
 ccaataatat gtacatttgg aggatcatct tcccagggtc ttttaagact ttctgaaaaa   1320
 gccttttcta ccttaaatgt caagacatct ccatgaacaa ttctcagttt cccaggtgct   1380
 gcatcagaaa gcatctgtaa tccaggaata aatcgagtgt ccttttcaac caccagaagt   1440
 tcagcgacgt cggcattaag aatagatctt gtgattcccc ctggcccagg gcccacttcg   1500
 taaacataag catttgtcag attgccagct ttccttacaa tcttatctgt cagcctcaag   1560
 tccaggagga aattctgtga tagctgcttc gctgcttgca gtcttaacaa cttaatgatt   1620
 tctcgaatcg tgggcaacgg agggagacgg caagtgctga gttttccgga ggcagccatg   1680
 atacgcggca agcaccatcc acccctacct cacccaggac cttcaccgcc gctcccactt   1740
 cagattgtaa c                                                        1751



      <210> 2203
      <211> 1222
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> misc_feature
      <222> (1)...(1222)
      <223> n = a,t,c or g


      <400> 2203
 cccacgcgtc cggatgccgg aggctccatg actatccaca cctttggtgc ctacttcggg     60
 ctcgtccttg cgcgggttct gggcaggccc gagctggaga agagcaagca ccgccagggc    120
 tccgtctacc attcagacct cttcgccatg attgggacca tcttcctgtg gatcttctgg    180
 cctagcttca atgctgcact cacagcgctg ggggctgggc agcatcggac ggccctcaac    240
 acatactact ccctggctgc cagcaccctt ggcacctttg ccttgtcagc ccttgtaggg    300
 gaagatggga ggcttgacat ggtccacatc caaaatgcag cgctggctgg aggggttgtg    360
 gtggggacct caagtgaaat gatgctgaca ccctttgggg ctctggcagc tggcttcttg    420
 gctgggactg tctccacgct ggggtacaag ttcttcacgc ccatccttga atcaaaattc    480
 aaagtccaag acacatgtgg agtccacaac ctccatggga tgccgggggt cctgggggcc    540
 ctcctggggg tccttgtggc tggacttgcc acccatgaag cttacggaga tggcctggag    600
 agtgtgtttc cactcatagc cgagggccag cgcagtgcca cgtcacaggc catgcaccag    660
 ctcttcgggc tgtttgtcac actgatgttt gcctctgtgg gcgggggcct tggaggcatc    720
 atattggtct tatgcctcct agacccctgt gccctgtggc actgggtggc accctcctcc    780
 atggtggggg gcagagaagc ctcacagatc ctcccctacc accaccaggg ctcctgctga    840
 agctaccctt tctggactcc ccccccagac tcccagcact acgaggacca agttcactgg    900
 caggtgcctg gcgagcatga ggataaagcc cagagacctc tgagggtgga ggagatactc    960
 acttatgcct aacccactgc cagcccatga taggactttc ttcttttcga acaagatgac   1020
 tggctgttac aagaaaaatt tttttgagct ccccttgctc gacatgcaag aaaggaccca   1080
 tagacccata aggagggcgg tttccacagg ctaangcctc acccagtaga gggccctgag   1140
 aggacgggca ctttttggaa aaggtgcccg cctgtgctaa aactggtttt tcggactccc   1200
 gttcccgccc ccgccccccc cg                                            1222



      <210> 2204
      <211> 3325
      <212> DNA
      <213> Homo sapiens


      <400> 2204
 ctgagtcgcc tgcaggcagc gtgccaccgg ctgaagctct ggccagagct gcaggacaat     60
 ggtggggact atgtctcagc tgctttgggc cccctgacca ccctcctgga gcagggcctg    120
 ggggctcggc tgaacctgct ggctcactct cgacccccag tcccagagtg ggacatcagc    180
 caagatccac caaagcacaa agactctggg accctgaccc tgggactcct tctccggcct    240
 gagggactga ccagcgtcct tgagctgggt ccagaggcag accagcctga ggctgctaaa    300
 ttccgccagt tctggggatc ccgctcggag cttcggcgtt tccaggacgg agccattcgg    360
 gaagctgtgg tctgggaggc agcctctatg tcccagaagc gccttattcc ccaccaggtg    420
 gtcacccacc tcttggcact ccatgctgac atcccagaaa cctgtgtcca ctatgtgggg    480
 ggccccctgg atgcacttat ccaaggcctg aaagagacct ccagcacagg tgaggaggcc    540
 ctggtagcgg cggtacgttg ctacgacgac ctcagtcgcc tactgtgggg gctagagggt    600
 ctcccactga ccgtgtctgc tgttcaggga gctcacccag tgctgcgcta cacagaggtg    660
 ttcccaccaa ctccagtccg tccagccttc tccttctatg agactctgcg ggagcggtcc    720
 tcactgctgc cccggctcga taagccctgt ccggcctacg tggagcccat gaccgtggtt    780
 tgtcacctgg agggcagtgg ccagtggcca caggacgctg aggccgtgca gcgggtccga    840
 gctgccttcc agctgcgcct ggcagagctg ttgacacaac agcatggtct gcagtgccgt    900
 gccactgcca cgcacacgga tgtccttaag gatggatttg tgtttcggat tcgcgtggcc    960
 tatcagcggg agccccagat cctgaaggag gtgcagagcc cagaggggat gatctcgctg   1020
 agggacacag ctgcctccct ccgccttgag agagacacaa ggcagttgcc actgctcacc   1080
 agtgccctgc acggactgca gcagcagcac ccagccttct ctggtgtggc acggctggcc   1140
 aagcggtggg tgcgtgccca gcttcttggt gagggtttcg ctgatgagag cctggatctg   1200
 gtggccgctg cccttttcct gcaccctgag cccttcaccc ctccgagttc cccccaggtt   1260
 ggcttccttc gattcctttt cttggtatca acgtttgatt ggaagaacaa ccccctcttt   1320
 gtcaacctca ataatgagct cactgtggag gagcaggtgg agatccgcag tggcttcctg   1380
 gcagctcggg cacagctccc cgtcatggtc attgttaccc cccaagaccg caaaaactct   1440
 gtgtggacac aggatggacc ctcagcccag atcctgcagc agcttgtggt cctggcagct   1500
 gaagccctgc ccatgttaga gaagcagctc atggatcccc ggggacctgg ggacatcagg   1560
 acagtgttcc ggccgccctt ggacatttac gacgtgctga ttcgcctgtc tcctcgccat   1620
 atcccgcggc accgccaggc tgtggactcg ccagctgcct ccttctgccg gggcctgctc   1680
 agccagccgg ggccctcatc cctgatgccc gtgctgggct atgatcctcc tcagctctat   1740
 ctgacgcagc tcagggaggc ctttggggat ctggcccttt tcttctatga ccagcatggt   1800
 ggagaggtga ttggtgtcct ctggaagccc accagcttcc agccgcagcc cttcaaggcc   1860
 tccagcacaa aggggcgcat ggtgatgtct cgaggtgggg agctagtaat ggtgcccaat   1920
 gttgaagcaa tcctggagga ctttgctgtg ctgggtgaag gcctggtgca gactgtggag   1980
 gcccgaagtg agaggtggac tgtgtgatcc cagctctgga gcaagctgta gacggacagc   2040
 aggacattgg acctctagag caagatgtca gtaggatgac ctccaccctc cttggacatg   2100
 aatcctccat ggagggcctg ctggctgaac atgctgaatc atctccaaca aaacccagcc   2160
 ccaactttct ctctgatgct ccagcattgg ggcaggggca tggtggccca tgtagtctcc   2220
 tgggcctcac catcccagaa gaggagtggg agccagctca gagaaggaac tgaacccagg   2280
 agatccatcc acctattagc cctgggcctg gacctccctg cgatttccca ctcctttctt   2340
 agtcttcttc cagaaacaga gaaggggatg tgtgcctggg agaggctctg tctccttcct   2400
 gctgccagga cctgtgccta gacttagcat gcccttcact gcagtgtcag gcctttagat   2460
 gggacccagc gaaaatgtgg cccttctgag tcacatcacc gacactgagc agtggaaagg   2520
 ggctatatgt gtatgaatag accacattga aggagcacaa tgccctcctg tgttgatgcc   2580
 acttcccagg gtggagacag tggaaaagaa ccgaggacag gaaaggattg ggtaggtgaa   2640
 ggggtcaggg gactggtagt cacccaatct tggagaggtg caaaaagcac tgggggctac   2700
 ccgttagctg catctgccct ggctgtttgc ccgttcatgt cacaaactgc cactactatg   2760
 tacctgcagt ggggttgcag agatggggga gactcaagtc ttactcccca ggagctccca   2820
 gggcccaagg aggagaatgc tgcctccttt cagtctggtc tacacccact ttctggtagc   2880
 ctctctgctt cctgtaattc tggctgtttt tccagactca gctcaaatag tgcccctcct   2940
 taagcccatc cctcgccccc agcctgaggt gatctttccc tcctctgaac tattagagca   3000
 gttactgtct gttcagttcg tttggcaggc acacacagtg gcataaattc tattgttttg   3060
 aactctgatt taaaattaaa ttgcagctgg gcgtagtggc tcatgcttgt aatcccaaca   3120
 cttagggagt caggagaatc acttgagctc aggagttcta gaccaatctg ggcaacagag   3180
 agaccccatc tcttttaaat aaaaagttaa attgcttaat ttcccccgta ttcctggcct   3240
 gtctgcccct ttcacataat tttaacctgg tttcttgtat gtaaactcct tgagggcaag   3300
 aacatgtttg aacataaaaa aaaaa                                         3325



      <210> 2205
      <211> 867
      <212> DNA
      <213> Homo sapiens


      <400> 2205
 ggcacgaggc cagataagtg cagggaacac ttgctggctg tcagcagttt tctttttgcc     60
 ttgatctggg gctttggagc ccaccttccc tccaggtacc taccaggatg ggggatggga    120
 gatgcagagg gctgagatgg actggcccat ggaagtaaaa acccacatga catcactgtt    180
 agggtatggt ggagtgtgtg agtgtgtcat aaatggaagt gttgtaactg tctgacgctt    240
 ttgcctgtgt gtccatctga gcaggttctg gcccatcttt gataccttca taagggattc    300
 tattagtcgc ctctccaact accctgagcc accaccctca gccttggtgt ttgatctaca    360
 tgtaagccct gaagatggaa cactggtccc cttcactggg ccaatacctg aggcagccac    420
 atcaaaggaa ctttggggca ccttttcacc cttctatcca ggtactgaac gggtttttgt    480
 atgtgatgga cctgcttctg ttcagggggg acagccagtg ttgctggttg ggagaaggca    540
 gcaacagggg aagtcagcct ttgtggaggt gctggtagag ccacatcacc cttacatata    600
 cagcccccat ccaccctgcc ttcagttcct cccacctccg tctcctgctg agcagaggaa    660
 tcccagggcc aaacacaagc ccagcccaca gccctgggca tcaccaggat tctaaaccct    720
 ccctcctctt cttgctggag gacctgcacc tagccacttc tggtgaggag ctgcgaagag    780
 ggaaggaagg agctactgtc atctcttgag actataaaat ccctagcaat attcattgac    840
 tctcaaatat atgtctgtag atctaaa                                        867



      <210> 2206
      <211> 471
      <212> DNA
      <213> Homo sapiens


      <400> 2206
 cgatgggccg tgtgcggtgg aattcctctg tgcatggggg gctgctcggg gcagggtgcc     60
 ggggggtagg aggcagcgcc gatcggctgg aagagagtgt ggtgtgatgg acgggcagct    120
 tcctgtgtgc tccaagggat gagcctcgtg gggcagaggg cccggggccg ccgcctggcc    180
 tgggagtccc tccctggttt ttattctcag tacctcaggc tcccctgtgt acttggaggg    240
 gcagggagcc ctttcctcgg ttctggcctc cagaccaggg taagggcagg cccctccaac    300
 aggtgctcac agccaccgag gcaggggctg cagccaccca ctgggagtct tgtttttatt    360
 tataataaaa ttgttgggga caaaaaaaaa aaaaaaaaag cgcccgctcg attttaaggg    420
 ccccgttaaa ccccgtggat caccctcgct ggtccttttt attggccacc c             471



      <210> 2207
      <211> 924
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> misc_feature
      <222> (1)...(924)
      <223> n = a,t,c or g


      <400> 2207
 tttcgtgtaa gatataactc aactttgaaa atgtcagccg ttatagttga agaaatctga     60
 cccaagagac ttcgctccgc tgcaagatgg aaggaagctt aagtaagaca taaatttgta    120
 atgaacttgc tcacaacatc cgccgccact gtgacttgca gtcatcatcc attaccacaa    180
 aattagttgc aggatggcta ctcgtatccc tccacacatg atcatcagta tttgcctcct    240
 gtgtcccaac cggcctgagt caaggttacg actcactgat taaaaagagg gactttttca    300
 aatactttgc acttttgatt gtgtattatg gataccaagg aagagaagaa ggaacggaaa    360
 caaagttatt ttgctcgact gaaaaagaaa aaacaagcca aacaaaatgc agagacagcc    420
 tcagctgtag ctacaaggac tcatactggg aaggaagata ataatacagt agttttagag    480
 ccagacaagt gcaacattgc tgtggaagag gaatatatga ctgatgagaa aaaaaagaga    540
 aaaagtaatc agttaaagga gatcaggcgt acagaactaa agagatatta tagtattgat    600
 gacaatcaaa acaaaacaca tgataaaaaa gagaagaaga tggtggttca gaagccccat    660
 gggactatgg aatacactgc tggaaaccag gacaccctaa actccatagc actgaaattt    720
 aacatcactc ccaataaatt ggtggaactg aataaacttt tcacacatac tattgttcca    780
 ggccaggtcc tttttgtgcc agatgccaac tctccttcca gtaccttaag gctatcatca    840
 tccagtcctg gtgctactgt ctctccttca tcatnagatg cagaatatgn taattggctg    900
 atgctgactt agcacggaag gctt                                           924



      <210> 2208
      <211> 384
      <212> DNA
      <213> Homo sapiens


      <400> 2208
 gcaaactggg attattttat gaatatcttg aaatgattat tcagtttggg ttcgtcacct     60
 tatttgtggc ctcttttcca ctggcccctc tgttggctct cgtgaacaat atattggaaa    120
 taagagtgga cgcatggaaa ctgaccaccc agtttagacg cctggtacca gagaaagccc    180
 aagacattgg agcatggcag cccatcatgc aaggaatagc aattctggct gtggtgacca    240
 atgccatgat catagctttc acgtcggaca tgatcccccg cctagtgtac tactggtcct    300
 tctccgtccc tccctacggg gaccacactt cctacaccat ggaagggtac atcaacaaca    360
 ctctctccat cttcaaagtc gcaa                                           384



      <210> 2209
      <211> 3261
      <212> DNA
      <213> Homo sapiens


      <400> 2209
 tttttttttt ttttttgata tttaaaaaat cattttactt attaaaactt tctcatttcc     60
 caaggcactt cagtagcttt cacaaaaaca tgtttgttct tttttaacca ggtgaggcat    120
 atgctttaag gagtaccatg gtaacataat cagcaaagag aagacaatta cactgaacac    180
 aaaatatcac ccaataaagt tacagggact aaagtgaggc tactctgaaa gactatgaac    240
 acaatttaaa ttggggtttt gtaatatcct ccccatgact aagtatcaaa aaaggaacac    300
 acacaatgac cctgtttttg gcacttagag aaagtgctag aggcttaggg ctggtaaggc    360
 cttgcaccca gtggcagctg cagacaattg ccagagtgat tctgtgttta aaaaaaaaaa    420
 aaaaaaaaga cacaaaccag gaggctaagg aaccagcctt tcccaagtgc attctgaagg    480
 gcaaataaca aggagaaaag gatacaacaa caaacaaata aacagtaaaa caaaacccac    540
 attacagctt tgagagaaaa gacaacgttg ctcatctctc tcacctgata aatttccttt    600
 aaaccataca taagacgcta tagtagcaag gaggtttcca cagcagtgga aaacaagaat    660
 agtagattca atggagcatt tattatgagc ctggacaagc ccagtgcttt gatcagatgt    720
 aaacaagtct actcagtcgt catgctgagt ggtcttaaga gctcacacat cagtgcactt    780
 tgctggtgat ctgcatctgc tcattctgct ccatcttcat tacctttcac tttccctagc    840
 tctgcgctct cctgccctgg ggaagcaatg atccagttaa tgtcctctgt aactgagaaa    900
 aggtaagaat caaactcctt gtgcaattac ttccttttcc tctaaagttc accactagag    960
 gggagtgggg aaaggggtgg gggacttaga cctctagcct tattaggggc cttttcaagt   1020
 agtctaaaat taaaatgtac atttagcata tgcttctcac attcctccag atctcactgg   1080
 ttctagtgaa aaattaactg ctttggaggt gctgagtcca tcattgtaat agttaggact   1140
 tagatgaagt tgtctgtagg tagccccagt gtccctagag gaaggtggtg ctctagggcc   1200
 atatgtagcc tctgagtgtg ggtgcccatc caggagcaag tcagacacag gtcaagagga   1260
 caaacagcaa aggcctttgt cactgaagga ctcggagtct gcacaagctg gccatttctg   1320
 gcaagacagt ctttcctctt cagtttctcc cttactggaa gcgatgttag aaggctgtgc   1380
 ttttaaggat tgtgggcctt tcttgaccat cttttaacat ccttgtgtga cttggagttt   1440
 ttctgtgttt cattcctttg actcttagca tctggtcaat ggtgtctggg agtggggtac   1500
 cgaagctctc tgggagaaac aaggtgagga tggctgtcag gatggtcaga cttcccatga   1560
 gaatgtaggg caggaagcgg tcgtaggcac caaggtaaac gaagtaggga gacaggatgc   1620
 tgcccaggcg ggatgctgtg gagctgactc ccacacccat gtttctcacc actgtgggat   1680
 acagctcggc tgtgtacacg tagaccatgg aaaaggcagc cgtgactcca aacttgccca   1740
 ccatcaccag gactgtagcc aaataataca agtctggggg taccagctgc atgaagagaa   1800
 ggacactgcc acccaggaag agggcagtgg ccatggaata gcgccggggc aaatattgca   1860
 gcagcagcca ggccaacaca tatgctggga cttcaaccat cgctgaaagg aagcagttca   1920
 caaagatgtc cccatgcaag ttaggagtat caagcgaaag cccaaaatag cccactgata   1980
 tggtcatcca cagcattatg gacatgatgg tgaccatccg gatattccag gttcgaagca   2040
 gatccagaat gttgtgggac tgctgcttct tggaacttag gtcttgtaac tcactcgggt   2100
 caaagatagt ggaaggcaca acaatcccat tggctttggc agccttgcgg atgatcacct   2160
 ctgcctcttc aaatcgtccc tgagagatga gccatcgggg ggactcaggg atgaaccacc   2220
 agagtgccac gcacagcacc cccggcatcg tcagcgccac cagcagcatc cgccagtctc   2280
 ggatgaagta agcaaacagt ggcagcacca tgtagccaaa tgcataaaat atgcacactc   2340
 ctaacgtaga gaatattata cgaactgact tgccaagaat ttctgtcccc aggacaaatg   2400
 ctgccacata gttggagatc tggcccatgc ctacaaggac aaacagcacg acaaacatct   2460
 caaaattctt cgagaagatc tgcaggaagc tgaagcctgt ctgcatgccc atggtcacga   2520
 acagcacatt cttccggcca aacctgtctg acagctgccc tgaaatgaag gagcccaaca   2580
 gcacacccac gaagaacaag gagattgtga gtggggcctt ccagtcgtcc tcacacacca   2640
 ggttccactc ggtcacaatg gtggacaggt agacgtcctg actgaactcc cagccatcca   2700
 gacagctctc ctgctccagc tgccccaggt ccacgtcgcg ccccggctcc agcccgagcg   2760
 ccgagaagtt ggcgatggtg gcgagccggt agcggcggca gctgtggggc acctcgcggc   2820
 cgtcccgcag ccgcagtggg acagtgtggt tgcgccaggc gctgctcagg ttcgcggcgt   2880
 ccggcacccg gcagcggtgc tccggggtcg ctatcaggaa cacggaggac aggccggtga   2940
 agccattggg gatgatgctg gcgctgagca ggaagaagat gaggcgctgg aagggccccc   3000
 actcgcccag gaaggcggtc acctcgtcgt agtcccgcat gccgccctca gaggcccaca   3060
 gagcgcggcc tggggtctgg gaacgcggcg ggctttgcgc gtgcgcgcgg ggcacccgcc   3120
 gccgaccagg caagccaggc agcaggcgac ccaagaccgt ccgcggaggg taggctcgcg   3180
 agctgacacc gccgccttgg tcctgccgcg gctggcctta catatggcgc acgaccaggg   3240
 aaggttccgg gcctgggccg c                                             3261



      <210> 2210
      <211> 2153
      <212> DNA
      <213> Homo sapiens


      <400> 2210
 atggacattc ttggatgggc ttcacgtgct cataagtgga agggccgggc cacaggcacg     60
 cacgtcttca acctcatgag agagtacctc atctctctcc agtgttgtgc cagtgagcag    120
 gcagcatcgc ctgagcatgg agcttctttc agggtctgga agtctcttgg atttcagaaa    180
 ctgatcttgt cactgatctg tccccagtgc ctgcagtcac ttactaggga gacatggatg    240
 agatttaaaa gcaagaagac aaaaggacct gatttaagac ttgtcatgga tgccaacaaa    300
 tgggaattca ggcgccacgc cttgcgcccg gcgcttacct ttccgaatga gggcggcgat    360
 ctcggggtcg aagccctgcc ggtggcactt cctccagagg cccatgttgg tggagttgta    420
 ctgccggctg cactcgtccg cggggctcat ggcgaacagc tgccggcgat tccgggcccg    480
 gaggagtttg ccctcccagc ggtccaggcg cgagcggctc gcccggagcg gcaagttgtt    540
 gttattgttg taaatgaagc cggggtcgac ccggcgggtg ttgaaggcct tgcacctgtc    600
 cctgtgcttc ctggcgtccg tctcgaagcg actgccccga agcagccgcc tcggctccca    660
 gcccggcttc gggcgccgct gccctcgggc cggaaactaa atgccaagtg tcctcggctg    720
 cggtggggct tctttgtgca ggatggtgac gggacagaac tcgcctgtct ctctgagggg    780
 gacggggggt gctgtcagga ggcgccactg gaccaccggc cgcggcggct ccgaggcctc    840
 gcaggctcgg ctggtgcccg ggaggcgcga gagcccaggc tgcgcccagg ggactgggga    900
 aatcgcattg cccgggtgcg ggcgccggag gaagctgctg ccgcgctctc tcgtccggcg    960
 cgggtagctg cagccttggc taaaacccac agacgagaac accgagcgcg cagccaaaag   1020
 ctagtgatgt catccgtgca acaaggaaaa ctaacaacca gaaaggacat ctacaccgaa   1080
 aacccatctg tacatcacca tcatcaaaga ccaaaagtag ataaaaccac aaagatgggg   1140
 aaaaaacaga acagaaaaac tggaaactct aaaaagcaga gcgccttttc ctcctccaaa   1200
 ggaatgcagt tcctcaccag caatggaaca aacctggacg cgataatgac tttgacgagc   1260
 tgagagaaga aggcttcaga ggatcaaatt actctgagct acgggaggac attcaaacca   1320
 aaggcaaaga agttgaaaac tttgaaaaag atttagaaga atgtataact agaataacca   1380
 atacagagaa gtgcttaaag gagcggatgg agctgaaaac caaggctcga gaactacgtg   1440
 aagaatgcag aagcctcagg agccgatgtg atcaactgga agaaagggta tcagcgatgg   1500
 aagatgaaat gaatgaaatg aagcgagaag ggaagtttag agaaaaaaga ataaaaagaa   1560
 acgagcaaag cctccaagaa atatgggact atgtgaaaag accaaatcta cgtctgattg   1620
 gtgtacctga aagtgatgtg gagaatggaa ccaagttgga aaacactctg caggatatta   1680
 tccaggagaa cttccccaat ctagcaaggc aggccaacgt tcagattcag gaaatagaga   1740
 gaatgccaca aagatactcc tcaagaagag caactccaag acacataatt gtcagattca   1800
 ccaaagttga aatgaaggaa aaaatgttaa gggcagccag agagaaaggt cgggttaccc   1860
 tcaaaggaaa gcccatcaga ctaacagcag ttctctcggc agaaacccta caagccagaa   1920
 gagagtgggg gccaatattc aacattctta aagaaaagaa ttttcaaccc agaatttcat   1980
 atccagccaa actaagcttc ataagtgaag gagaaataaa atactttata gagaagcaaa   2040
 tgctgagaga ttttgtcacc accaggcctg ccctaaaaga gctcctgaag gaagcgctaa   2100
 acatggaaag gaacaaccgg taccagccgc tgcaaaatca tgccaaaatg taa          2153



      <210> 2211
      <211> 2153
      <212> DNA
      <213> Homo sapiens


      <400> 2211
 atggacattc ttggatgggc ttcacgtgct cataagtgga agggccgggc cacaggcacg     60
 cacgtcttca acctcatgag agagtacctc atctctctcc agtgttgtgc cagtgagcag    120
 gcagcatcgc ctgagcatgg agcttctttc agggtctgga agtctcttgg atttcagaaa    180
 ctgatcttgt cactgatctg tccccagtgc ctgcagtcac ttactaggga gacatggatg    240
 agatttaaaa gcaagaagac aaaaggacct gatttaagac ttgtcatgga tgccaacaaa    300
 tgggaattca ggcgccacgc cttgcgcccg gcgcttacct ttccgaatga gggcggcgat    360
 ctcggggtcg aagccctgcc ggtggcactt cctccagagg cccatgttgg tggagttgta    420
 ctgccggctg cactcgtccg cggggctcat ggcgaacagc tgccggcgat tccgggcccg    480
 gaggagtttg ccctcccagc ggtccaggcg cgagcggctc gcccggagcg gcaagttgtt    540
 gttattgttg taaatgaagc cggggtcgac ccggcgggtg ttgaaggcct tgcacctgtc    600
 cctgtgcttc ctggcgtccg tctcgaagcg actgccccga agcagccgcc tcggctccca    660
 gcccggcttc gggcgccgct gccctcgggc cggaaactaa atgccaagtg tcctcggctg    720
 cggtggggct tctttgtgca ggatggtgac gggacagaac tcgcctgtct ctctgagggg    780
 gacggggggt gctgtcagga ggcgccactg gaccaccggc cgcggcggct ccgaggcctc    840
 gcaggctcgg ctggtgcccg ggaggcgcga gagcccaggc tgcgcccagg ggactgggga    900
 aatcgcattg cccgggtgcg ggcgccggag gaagctgctg ccgcgctctc tcgtccggcg    960
 cgggtagctg cagccttggc taaaacccac agacgagaac accgagcgcg cagccaaaag   1020
 ctagtgatgt catccgtgca acaaggaaaa ctaacaacca gaaaggacat ctacaccgaa   1080
 aacccatctg tacatcacca tcatcaaaga ccaaaagtag ataaaaccac aaagatgggg   1140
 aaaaaacaga acagaaaaac tggaaactct aaaaagcaga gcgccttttc ctcctccaaa   1200
 ggaatgcagt tcctcaccag caatggaaca aacctggacg cgataatgac tttgacgagc   1260
 tgagagaaga aggcttcaga ggatcaaatt actctgagct acgggaggac attcaaacca   1320
 aaggcaaaga agttgaaaac tttgaaaaag atttagaaga atgtataact agaataacca   1380
 atacagagaa gtgcttaaag gagcggatgg agctgaaaac caaggctcga gaactacgtg   1440
 aagaatgcag aagcctcagg agccgatgtg atcaactgga agaaagggta tcagcgatgg   1500
 aagatgaaat gaatgaaatg aagcgagaag ggaagtttag agaaaaaaga ataaaaagaa   1560
 acgagcaaag cctccaagaa atatgggact atgtgaaaag accaaatcta cgtctgattg   1620
 gtgtacctga aagtgatgtg gagaatggaa ccaagttgga aaacactctg caggatatta   1680
 tccaggagaa cttccccaat ctagcaaggc aggccaacgt tcagattcag gaaatagaga   1740
 gaatgccaca aagatactcc tcaagaagag caactccaag acacataatt gtcagattca   1800
 ccaaagttga aatgaaggaa aaaatgttaa gggcagccag agagaaaggt cgggttaccc   1860
 tcaaaggaaa gcccatcaga ctaacagcag ttctctcggc agaaacccta caagccagaa   1920
 gagagtgggg gccaatattc aacattctta aagaaaagaa ttttcaaccc agaatttcat   1980
 atccagccaa actaagcttc ataagtgaag gagaaataaa atactttata gagaagcaaa   2040
 tgctgagaga ttttgtcacc accaggcctg ccctaaaaga gctcctgaag gaagcgctaa   2100
 acatggaaag gaacaaccgg taccagccgc tgcaaaatca tgccaaaatg taa          2153



      <210> 2212
      <211> 445
      <212> DNA
      <213> Homo sapiens


      <400> 2212
 ggaaattgac cgcaagtggt actatgacag ctacacctgc tgccccccac cctggttcat     60
 gatcacagtc acgctgctgg aggttgcctt tttcctctac aattgggtgt cactaggtca    120
 atttgtactg caggtaactc atccacgtta cttgaagaac tccctggttt accacccaca    180
 gctgcgagca caggtttggc gctacctgac atacatcttc atgcatgcag ggatagaaca    240
 cctgggactc aatgtggtgc tgcagctgct ggtgggggtg cccctggaga tggtgcatgg    300
 agccacccga attgggcttg tctacatggc cggtgttgtg gcagggtcct tggcagtgtc    360
 tgtggctgac atgaccgctc cagtcgtggg ctcttctgga ggggtgtatg ctctcgtctc    420
 tgcccatctg gccaacattg tcatg                                          445



      <210> 2213
      <211> 438
      <212> DNA
      <213> Homo sapiens


      <400> 2213
 agcgcagctt gcaggacgcg cagcgcctct tcttgatgag cgaggccgtg cagccggtga     60
 cacccgagcc ctgtgtcacc caggacagcg tgcgcttctc acacctcgtg gtggacctgg    120
 tgcaggctaa agacacgctc taccatgtac tctacattgg caccgagtcg ggcaccatcc    180
 tgaaggcgct gtccacggcg agccgcagcc tccacggctg ctacctggag gagctgcacg    240
 tgctgccccc cgggcgccgc gagcccctgc gcagcctgcg catcctgcac agcgcccgcg    300
 cgctcttcgt ggggctgaga gacggcgtcc tgcgggtccc actggagagg tgcgccgcct    360
 accgcagcca gggggcatgc ctgggggccc gggacccgta ctgtggctgg gacgggaagc    420
 agcaacgttg cagcacac                                                  438



      <210> 2214
      <211> 670
      <212> DNA
      <213> Homo sapiens


      <400> 2214
 gtcgacccac gcgtccgccc acgcgtccga cggcacctat cgtcaccact ccagtgacaa     60
 caagaggtgg aggaagaaga tcatagagaa gcagccgcag agccccaaag cccctgcccc    120
 tcagccgccc cccatcctca aagtcttcaa ccggcctatc ctctttgaca tcgtgtcccg    180
 gggctccact gctgacctgg acgggctgct cccattcttg ctgacccaca agaaacgcct    240
 aactgatgag gagtttcgag agccatctac ggtgaagacc tgcctgccca aggccttgct    300
 gaacctgagc aatggccgca acgacaccat ccctgtgctg ctggacatcg cggagcgcac    360
 cggcaacatg cgggagttca ttaactcgcc cttccgtgac atctactatc gaggtggggc    420
 cccgggctgg gcaggggtgc cacgggggct gatggagacg ctgtcctttg cttgtctgac    480
 tcctgagact tttgatctgg gcctaagtgc cagcatgtac ccaggacctg acaaatggat    540
 ggatggatgg atggatggat ggatgcatgg atgcatggat agatcgatgg atgaaggaac    600
 ggtaactacc ccttccaact ttgtttcgag tttcagaata gaagattcca ctgggtgcgg    660
 tggcttctac                                                           670



      <210> 2215
      <211> 670
      <212> DNA
      <213> Homo sapiens


      <400> 2215
 gtcgacccac gcgtccgccc acgcgtccga cggcacctat cgtcaccact ccagtgacaa     60
 caagaggtgg aggaagaaga tcatagagaa gcagccgcag agccccaaag cccctgcccc    120
 tcagccgccc cccatcctca aagtcttcaa ccggcctatc ctctttgaca tcgtgtcccg    180
 gggctccact gctgacctgg acgggctgct cccattcttg ctgacccaca agaaacgcct    240
 aactgatgag gagtttcgag agccatctac ggtgaagacc tgcctgccca aggccttgct    300
 gaacctgagc aatggccgca acgacaccat ccctgtgctg ctggacatcg cggagcgcac    360
 cggcaacatg cgggagttca ttaactcgcc cttccgtgac atctactatc gaggtggggc    420
 cccgggctgg gcaggggtgc cacgggggct gatggagacg ctgtcctttg cttgtctgac    480
 tcctgagact tttgatctgg gcctaagtgc cagcatgtac ccaggacctg acaaatggat    540
 ggatggatgg atggatggat ggatgcatgg atgcatggat agatcgatgg atgaaggaac    600
 ggtaactacc ccttccaact ttgtttcgag tttcagaata gaagattcca ctgggtgcgg    660
 tggcttctac                                                           670



      <210> 2216
      <211> 1004
      <212> DNA
      <213> Homo sapiens


      <400> 2216
 gccaataata tttttattgt catagatttc cttcaagata gcccctaaaa gttacttcag     60
 agctatggta aacaggaaaa ccctgcctct tcattttata aacagctgca gaaaacctgt    120
 cttgggtttt taacacttta agaaccaagc tgagcatggc acatatgcct gtaatcccag    180
 ctccttggga ggctgaggtg gaaggattgc gtgagcccag gagtttgagg ccagactggg    240
 caacatagtg agacactatc tcttgaaaga aagaaaatga aacaagacag ggtttttttg    300
 gttttgtttt tcatttttgt ttttgggcat gccctaaaaa taatggaata ttgccatatg    360
 ccattttaat tctatagctg ttgagaactt gtgttgattt cttccgcctg gttccattta    420
 tggtgttctt aattgtaccc ttcatggaat tcttattacc agtgtttctg aaactcttcc    480
 cagagatgtt gccatcaact tttgaaagtg aatccaaaaa ggtatgattt tttaacttta    540
 ataaaattta ataaacctta ttagaggagt ttttaggttt acagaaaact tgggcagaaa    600
 gtactactct cccccaccca accccatccc aatttctcct gtaattaata tcttgcatta    660
 gtgtgctata tttgtaatga ttaaaaaaac caatattgac atggttaatt attaaaagct    720
 catactttag gggcccactc ttcatgttga aagcatttcc tgtgggcttt gcaaatgcat    780
 aatttcatgt atcccaccca tcacagtatc atacaaaata gtttcactgc tctaaaaatt    840
 ccctgtgggc caggcacagt ggcttatgtc tgtaattcca gctccttggg aggctgaagc    900
 aagaggatca cttgagccca ggaggtcaag gctgcaatga cctatgatag tgtcactgca    960
 ctccagaggc actgggtgac agggggagac cctgtctcaa aaaa                    1004



      <210> 2217
      <211> 588
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> misc_feature
      <222> (1)...(588)
      <223> n = a,t,c or g


      <400> 2217
 ccggtccgga attcccgggc tcggccaagc tcgtgttcct cgacctcagc tacaacaact     60
 tgacccagct gggcgccggc gccttccgct cggccgggag gctggtgaag cttagcctgg    120
 ctaacaacaa cctggtgggc gtgcacgagg acgccttcga gaccctggag tcgctgcagg    180
 tgctggagct caacgacaac aacctgcgca gcctcagcgt ggccgccctg gccgcgctgc    240
 ccgcgctgcg ctccctgcgt ctggacggga acccctggct gtgcgactgt gacttcgccc    300
 acctcttctc ctggatccag gagaacgcat ccaaactgcc caaaggcctt gatgaaatcc    360
 agtgctccct gcccatggag agcaggagga tatccctgcg tgcgtgtcgg aggccagctt    420
 cacgagtgta ggttcacctg tcatcacaga cctctgcatc atcattttct ctggtgtggc    480
 cgtgtcattg cggcatcatc tcagcttctc ctgccactgt ggtcagtgct ccagaggtgn    540
 cacccaacaa agatgcggag gatgaagacg aggacgagga tgactgag                 588



      <210> 2218
      <211> 611
      <212> DNA
      <213> Homo sapiens


      <400> 2218
 tgatgctgcc tgctgggccc ggggggctgt cttccactac ttcctgctct gtgccttcac     60
 ctggatgggc cttgaagcct tccacctcta cctgctcgct gtcagggtct tcaacaccta    120
 cttcgggcac tacttcctga agctgagcct ggtgggctgg ggcctgcccg ccctgatggt    180
 catcggcact gggagtgcca acagctacgg cctctacacc atccgtgata gggagaaccg    240
 cacctctctg gagctatgct ggttccgtga agggacaacc atgtacgccc tctatatcac    300
 cgtccacggc tacttcctca tcaccttcct ctttggcatg gtggtcctgg ccctggtggt    360
 ctggaagatc ttcaccctgt cccgtgctac agcggtcaag gagcggggga agaaccggaa    420
 gaaggtgctc accctgctgg gcctctcgag cctggtgggt gtgacatggg ggttggccat    480
 cttcaccccg ttgggcctct ccaccgtcta catctttgca cttttcaact ccttgcaagg    540
 tgtcttcatc tgctgctggt tcaccatcct ttacctccca agtcagagca ccacagtctc    600
 ctcttctact g                                                         611



      <210> 2219
      <211> 747
      <212> DNA
      <213> Homo sapiens


      <400> 2219
 atggtgctcc ttgaactaca catatcacaa acaagaaccc acagcagtcc tggttggcac     60
 tctgtagaaa caggatctcc aatgatgaag gaagagagga aaggaggggg agaaggagaa    120
 actctggttg atagagctga cgtgatttgg cccaaaatta gccccaaagc ctgtattccc    180
 catatacacc acccaagcct actgcttcag ttaaaccagg ctactcgtag ctttgcaaat    240
 atgatgtaca ttcccacctt gtccccatct gatcacacgc ctaagcgtgc tcccactgct    300
 tgcttactaa ttatcaaaca agttatgaaa ttattgatgg tgctaattat ttgggcggtt    360
 gacccgcaat atcgcctgaa tgcgatgatt gccaccaccg tggtgttgct gctactggca    420
 ctgattggcg gtatctggac gctacgtaaa tcgctaaaga acacagatga agaggagaga    480
 tattttatat cagagaaact ttctcagaat gacggcaggc aacgagttgg atttgcagcg    540
 gcgacgttgt ctcatcgcta cattgctgac cgtcagctgc cggataaagc catcgacctg    600
 atcgatgaag cagcatccag cattcgtatg cagattgact caaaaccaga agaactcgac    660
 cgactcgatc gtcgtatcat ccagctcaaa ctggaacaac aggcgttaat gaaagagtct    720
 gatgaagcca gtgaaaaaca tggatga                                        747



      <210> 2220
      <211> 3818
      <212> DNA
      <213> Homo sapiens


      <400> 2220
 tttttttcgc tatctaagga cataacttta ttggaaacaa agagtggggt gcagaagatg     60
 gctaggagtc aggctctgag ggaggtggtg gcttctcatc atcaggggga caatcgatga    120
 agtcggccag catggcagct gtgtcatcct gctccttttc ctggagagct tcggcctctg    180
 tctctgtctc catctcttct tctgcaggtg tctctggtgg gggctgcacc ttgtcactcc    240
 catcctcagt ctcctcttcc aacagggttg ggggagcaga gggctcttct tcaacaagct    300
 cctggggagg gggccctgcc gcagggcttt ccccttccct ctccacctct ccctgggagg    360
 ggagcgcttc aggggccagg gtgggagctg tgtcagcccc acgctcctcc tccgtccctg    420
 gctcctccac ttccaaaagc agcccgggtt cgggttcggg ttctggctgc acctttgggg    480
 gagactcagg gggaggcaga gctggaggca gggttgaggg tggaggtgca ccttcttcta    540
 cctcccctcc tgctgtgcca aactccaggt cttccacctc ttccagttct tcttcctcct    600
 cctcatcctc ctcttcttct tcttcctcta actcaccttc ttcttcctca aattcttcct    660
 caaactcttc ttcctcctct tcttcctctt caaaatattc ctcttcatcc tcttcctctt    720
 cctcaaagtc ttcctcctct tcctcttcct caaagtcttc ctcctcttcc tcttcttctt    780
 cttcttcttc ttcctcttct tcctcttcct cctcctcttc atcactgctg ttgatattaa    840
 taactgtcaa atcctcttcc agggctgggg gtcctccccc accaggagtc ccttcaggga    900
 ccaactgggg tggagggagc gtcacaggac caggaacagg cggcggcgga ggtgggggtg    960
 gcgggagagg ccctggggct gcaggaagtt cttcaggctc ctccttcgct ggcacaggag   1020
 gggaggctgt tggtggccca gtgggggcta tagggggtgg tgtggcacct gagggtggtg   1080
 ggggtggcag ggggggaagc ccctcgggca cgatcaccac gctgtcatca gagtcacttt   1140
 ccaaggagat ctccacatca gatgcctcct ccttgtcata gtggacaaag gctggtctgg   1200
 gcactctccc cccaaaagtt tcatctgggg gtatagtagg tgggggagtc ccactagggg   1260
 caaggatggg gtcctcattt gagcctgccc ggtggttctc agggccagga agaagccggg   1320
 gaggacagac actaggcctg gacagaaggc ctaggaggtt ggctgtggtg gaggtccagg   1380
 gctccgaggg cacagggcct gctgagggca tggggcctgc tgaagggcat ggggcctgct   1440
 gagggcatgg agcccactga gggcatgggg cccggaggat ggaacggtgg ggccctgaag   1500
 ggcgatgggg cctcaggagg gggactggag caggtgtggg gcaggtgggg cccatgggct   1560
 gcaggggagg aacccggggg tgggtcagag cagcacaggt caccagtgct tctgagcaag   1620
 aaagaggaga cctcaaggct atcttctcgc tggccgaggg agaaggcttg cagggcacag   1680
 gcaagaggag gtgggcagcg aggagatggg gccagcagca gcgccagcag caggcagtag   1740
 agttcacggc ggcagcggga gctcgtgtac ggggagctgc ctaggacctc accctgctgt   1800
 acacccatga ccagggggag gaccaggtca tgcagtctcc tgtgagtctc ctccttgatg   1860
 agaggcccac acatgaggat ggtccggctg aggcctctga gtgcagccgc acacacgtcg   1920
 ctgttggcat tgctatcccc tttccggtgg cttggcgggg ccatagcttc ccccacatcc   1980
 agctttagct tcttgggggc gctaggcttc ccagtctgca aactcccatc agggctcccc   2040
 cgcgggctac gcagcttaag ggcatcagct ggcggggaga tgtcgctgag caggtgggtg   2100
 agcagggcct ctccagaggc tcctccctga agcattcccg ccgaggcccc acaaacctgc   2160
 acccacagct ctaatatcgc atacaccttg gtccgaaccg tgctgtaagg cctctcctgg   2220
 cctggagaga gggaatctct accgatgctc caggaattga ggacctgggg aagcaggcgg   2280
 ccgatcagga tcccaaagcg caagagccgg cttccacacg cgaggatgag tgcagacagc   2340
 aggtccaagg ccttcaaggt ggatagaggg cagcagcagc agccgcaggg accatctcca   2400
 tgcaagctct ggagaaaaaa ggggcagaga taaagagtgg aggaagaaag tgagagccag   2460
 agagagacag aaacagggaa tgaccattta catatgtaca cataggtaag aaacccaacc   2520
 cctgatctca tctctcccaa caaaatcaaa cccctatcct ctaaaataga ccctggatgg   2580
 aaggtaagaa ggatggctgg gcctctcagc aatgactcag ctgagtcccc aaattcaccc   2640
 tcccccaagg aagcatttgc tacactctga cactgtgctc ctgtgtcacg acacatagga   2700
 agtgatgtta tttggacaaa agtagaagct ctctgggacg gactccagga tgacactgtt   2760
 tggggagact caggtcccca gtactttcct ggttgcctgg tatcctgagc aagggctctg   2820
 aagagatgac aaatcccact tacaatattc ttgctactga cgctgagggt ccggcagatg   2880
 aaatccagga tttcctgcac agggacggac acgggagctc caaactcaga gctgagcatg   2940
 agccctaggc agcgggccag tcccgaaaac ctctgccgaa gctggagaag gacatgggca   3000
 tcaccatctt ctgaggacag cagcatctcc accccagggc cttcattctg cacaggagca   3060
 gtctctgctc cctcgtacag ggcccccagc agggtgtgca gtgaggccag cagactgtgt   3120
 agctcctgct cccagctctc ggtgtgcttc aggccttggg aaaagccagc ccctaaagag   3180
 ggcagccggg aataacactc acaggccaac tgttggagct gagggctcaa ggcatccacc   3240
 ctagacagaa aaaatgaggc cagcttgcct ttgagagaac cacaagcccg agggaaatag   3300
 gtcatacaag ccttcattcc ttccaatgct gactgctcac actctggcct gaggcccagc   3360
 agggaggtga gaaggccagg gaggtggttc atggagatgt cccggaacag tgcaggcagc   3420
 tgggctgcat atcggaggag gtccctcagg acagccacgg ccagctccat tgtggcaggc   3480
 gggtcctggg tctgtaacac ctgctgaatg ctccgaagcc aagacacaca gtgctgctgg   3540
 aatagctctg tggggctctc ccctaccagc agggacagca gacacaggcc ctcaaaccga   3600
 gttttgatgg aactgagacg tgcattactg agactcacca atgccccaag agctgaaagg   3660
 ttctgggccc cgcccaccga cccatgcagc cgcaataggc acatgagccc gggcaaatgt   3720
 ggggccgagc ggtttggggg atgcaccgga gcaacggcag accccgttcg aggttgcagc   3780
 aaaccagaaa cactctccag cagcagcagg cggagccg                           3818



      <210> 2221
      <211> 282
      <212> DNA
      <213> Homo sapiens


      <400> 2221
 gtgcccacac caccactgct ccatatggga aagcaggaca gccagagggc tgtgcgacat     60
 caggcaagtc actgccccta tctctattcc caagctatca tcagaaatga ttgtagaagc    120
 gaccccacct accgtccatg ctgctgtgag gatgaaacga gaggaattaa gaaaaagttg    180
 atgactgatc ttctgaagga atgcatgcag agaagtaaga acaacaagga ctgtgcaaag    240
 attgggctga tgtgcacagt caaacagcag gcaacgggat ag                       282



      <210> 2222
      <211> 3341
      <212> DNA
      <213> Homo sapiens


      <400> 2222
 gaaccaagag agcctggtgc agtgccaggg gcctgccatc atcggggccc tcctgcgaaa     60
 ggtcccaagc tgggccatgg acatgaacgt gctcatgtcc gcccagctgc tgatggagca    120
 ggtggcagct gagggcagcg ggcccctcct gtacctactc taccagcatt tgctcttcaa    180
 ctttcacctc tggaccctca gtgacttcgc cgtgcgcctc ggtcacatcc agtacatgtc    240
 cagcatagtt cgggagcaca gacagaagct gcggaagaag tacggcgtcc agtttatctt    300
 ggatgctctg cgcacccact acagcccgca gcgggagcgc cccctggctg ctgacgacct    360
 acgcaccgtg cagacctccc tcctgggcct ggcgagggag ttcctggtgc ggagtctctc    420
 agcagatgac gtgcaggtca cgcagaccat gctgagcttt ttggcggcca caggcgatga    480
 cggtcaggcg gtgggtgcgc tggacctgct gctggccctg ctgcacggtt ccctggtgca    540
 ggagtccttg gctgtctttc tgttggagcc agggaacctc gaagtgctac tggccctgct    600
 agtgcggcca gggtcactgc ccctgctgcc cgatcgagtc tgcaagatcc tgcgcagact    660
 gcagcagaat gagcggctac ctgagcggag ccgccagcgc ctccggctgc gggagtgtgg    720
 tctccagggt ctggttgcct gcttgcctga ggggactgtt tccccccagc tctgccaggg    780
 cctctacaag ctgttcctgg gggcagattg cctgaacctc tcagatctgc tggctgtggt    840
 acagctgtcc ctccaggctg acctcagcgt tcgcctagac atctgtcgcc agcttttcca    900
 cctcatctac ggacagccag atgtagtgcg gcttctggcc cgacaggctg gctggcaaga    960
 tgtgctgacc cggctatatg tcctggaggc tgccacagcc ggcagccccc ctccgtcttc   1020
 cccagagtca cctacctccc ccaagccagc cccacccaag ccacccactg agtcacctgc   1080
 tgagccttca gatgtcttcc tgccctcaga ggccccctgc cctgaccctg atggctttta   1140
 ccatgctctc tccccattct gcacgccctt tgacctgggc ctggaacggt ctagtgtagg   1200
 atcaggcaac actgctggtg gtggcggcag cagtgggact cttactccag ccagccagcc   1260
 cggcactcct tcgccactgg atgggccgcg gccctttcct gctgctcctg gccgccacag   1320
 ctccagtctc tccaatgtgc tggaggacgg cagcctcccg gagcccacca ttagcgggga   1380
 tgatacctcg aacaccagca acccacagca aacctctgag gaagagttgt gcaatctgct   1440
 caccaacgtg ctgttctcgg tgacgtggcg tggcgtggaa ggcagcgatg aggctgcctg   1500
 gcgggagccg tggccaggtt ttctcagtgc tcacccagct gggggcctca gccacacttg   1560
 tgcgcccacc agactgcatc aagcgcagcc tcctggagat gatgctggag tcagccctga   1620
 ccgacatcaa agaggccccc gtgggggtcc tggccagcct cacccagcaa gcgctttggc   1680
 tgctgcgtct gctgcaggac ttcctgtgtg ctgaaggcca tggtaaccag gaactgtgga   1740
 gtgagaagct ctttgaaggt gtatgcagcc tacttgatcg cctgggagcc tggccccacc   1800
 tggccaacgg cacagctgat ctccgtgaga tggcgcagat tggcctacgg cttgtacttg   1860
 gctacatcct gctggaagac ccacagctgc atgcccaggc ctacgtgaga ttgcacatgc   1920
 tgctacagac tgcagtgcca gcccgccgcg aggaggcctg ctatgtgctc tccaagctgg   1980
 aggctgcact ggggcgggtg ctgaacacct cttctttgga gtcagccact gatgaggcag   2040
 ggtccccact tgcagctgca gcagctgcag cagctgcaga gcgctgctcc tggctggtgc   2100
 cactggtgcg cacgctgcta gaccgtgcct atgagccgct ggggctgcag tggggactgc   2160
 cctccctgcc acccaccaat ggcagcccca ccttctttga agacttccag gctttttgtg   2220
 ccacacccga atggcgccac ttcatcgaca aacaggtaca gccaaccatg tcccagttcg   2280
 aaatggacac gtatgctaag agccacgacc ttatgtcagg tttctggaat gcctgctatg   2340
 acatgcttat gagcagtggg cagcggcgcc agtgggagcg cgcccagagt cgtcgggcct   2400
 tccaggagct ggtgctggaa cctgcgcaga ggcgggcgcg cctggagggg ctacgctaca   2460
 cggcagtgct gaagcagcag gcaacgcagc actccatggc cctgctgcac tggggggcgc   2520
 tgtggcgcca gctcgccagc ccatgtgggg cctgggcgct gagggacact cccatccccc   2580
 gctggaaact gtccagcgcc gagacatatt cacgcatgcg tctgaagctg gtgcccaacc   2640
 atcacttcga ccctcacctg gaagccagcg ctctccgaga caatctgggt gaggttcccc   2700
 tgacacccac cgaggaggcc tcactgcctc tggcagtgac caaagaggcc aaagtgagca   2760
 ccccacccga gttgctgcag gaggaccagc tcggcgagga cgagctggct gagctggaga   2820
 ccccgatgga ggcagcagaa ctggatgagc agcgtgagaa gctggtgctg tcggccgagt   2880
 gccagctggt gacggtagtg gccgtggtcc cagggctgct ggaggtcacc acacagaatg   2940
 tatacttcta cgatggcagc actgagcgcg tggaaaccga ggagggcatc ggctatgatt   3000
 tccggcgccc actggcccag ctgcgtgagg tccacctgcg gcgtttcaac ctgcgccgtt   3060
 cagcacttga gctcttcttt atcgatcagg ccaactactt cctcaacttc ccatgcaagg   3120
 tgggcacgac cccagtctca tctcctagcc agactcccag accccagcct ggccccatcc   3180
 caccccatac ccaggtacgg aaccaggtgt actcgtggct cctgcgccta cggcccccct   3240
 ctcaaggcta cctaagcagc cgctcccccc aggagatgct gcgtgcctca ggccttaccc   3300
 aggtgagagc cctgggtgtg agggatgtga agtcgggacc c                       3341



      <210> 2223
      <211> 1522
      <212> DNA
      <213> Homo sapiens


      <400> 2223
 tcatgcctgc tgtgggcact gcccataaac cccattgtcc tctggctttg cgtgtgcatg     60
 agcaaactgg acagagccgg atgacaccaa gacgatgtgg agactgagtg ttcccttaga    120
 cagaagcccc cagacacaga actgcactgg agagccactg atgcccacag ggagacagga    180
 gctaccccag aggggtccag agcccatgga agccccagcc ccagccaggc cccagtcacg    240
 ccgtgtgcca gcagcaggtc ctgtggccag acaaccccac atgcggcccc cacactcaaa    300
 gcagggggag aagcagaaga tgccaggcag caggtggcca gggcagcgtg gccgtgggag    360
 gtggggttcc ccgctagagt ctgcgtaata gacacggaaa atctttaccg gcatacccat    420
 cttgcccctc ttgccaggaa cgccaggcag gcctgctcct gaggaaggaa tgcagtctgc    480
 agacaaaaac agggtgaaga ggagaggggg tacacagagg aactcagccc tagcgctgga    540
 gttctgcgaa ctgctgttcg tctcttcaaa gtggttttgt gctttgcctt ctactctccg    600
 actgaaagcg ctttctgctg cggttgcctt gctcgccgga gatcccgaat ttggagtgcg    660
 gaacgtctgg gtttgggtgg ctggaggggt gcggtgtaag agggtggcac atcggaccac    720
 ggaggccgga gcttttttcc ccgactggtt cgtctgggtc ttcgctgcca cgaagcgtgg    780
 agatggggag acctctggat gtgaacactc agagcccgtg tctggatcat ccggtggctc    840
 cccaccccgg gggcagtacc tgccaggtat gtgaccttga ccaagggcct cagttttccc    900
 atttgccgaa agggtttctc ctaagagaca ctgcaaatag cgttgccaga ctgctgcccc    960
 aggcatcaat gtacttacaa tgaggccggg gactccaggg gggcctggca ggcccagttc   1020
 tccccatttg gtggtgggga gaaggtgtcc acatctgtct gcctcataga actctaagct   1080
 ctctgaaggc aggggcaaga taatctgata aaccgaatag gttttctggg catgtctgtg   1140
 aaactgaaca acaacagcag cagctggaac tgaattttcc tgggagccca ggataggaac   1200
 tagactcccg ccatagagcc agatcttgtg tggagagaga ggatgcagga ttccactggg   1260
 taggcaccga ctgtccagtt gacccacttg tggtgctgat gcctaggcag cagggctgtg   1320
 gtcgggcttg aacaccatgg cctgcgcccc tctggagatc cagctttcca taagcaggta   1380
 cagggcagcc atgtttgttc tccagtgaag cagcaactgc cctgctccct ggtgcccagg   1440
 ctggatgcta cccagaatgc actttcagtg aggtgttagc tacaaggcca gactataacc   1500
 ttgagttcag cctttggaga ct                                            1522



      <210> 2224
      <211> 1557
      <212> DNA
      <213> Homo sapiens


      <400> 2224
 ttacagtttc aattcacctt ggaggtccct tcgtggtcgc caaagtgtta ccgggggtcc     60
 ttgctcccag agctcccaag aaggtggtgg gcgacttcca aaatggcggc aggccacttc    120
 caagatggtg gcaagccccg tgttctctga cctggggttg ttggcctcac ggattccaag    180
 gaatggaatc tgtcttaact tcacaatgac cgtattgcgt tttatgaaga caaaactcgt    240
 gagcatatcc acatcataga atggcagccc attactacta tcagtcacct tgttaactgt    300
 gtacacaaaa ccccatgttg agttcagtgt gcttttaatt tgataatact tctgaccatc    360
 aacagaacac tgaaagcacc cataaactgt ctcccttttg aagttcccca ttccacagag    420
 tatgcaaggc cctttgggaa tgttgtgatt aagtaagtta actcggatat gggtcccttc    480
 tttgagtgaa atatcagtca tgctgagagg tttgtcatag tagtcagaaa aaagatcatc    540
 caagtaaagc tgtgaacgag aaatgacatc catcactctt ctatcaaagg caccatccag    600
 gtatatgaag agttcaaaaa cactgaaagc tatggttgta tgtgctggga aaacaatagc    660
 tttgtccctt cccttgggat tctgttcatc cataaagtga aaccgcattg cttcccctcg    720
 aattccagca tgcacagaca gtgagcactg tcgtgtggtt cggatgctct ccatgaccac    780
 acacaatact gcctttctgc tgctccttga ctgacgtatc aagctgtggt caaagttaat    840
 tttttggtca tagattgtct tttccaccat gatgtgagtc tcactgtcca ggtctgacag    900
 cttggaattc tcagggttaa tcttcttggt attgatctca gggtcactgg acaccaagcg    960
 gctccaccac tccatcttct tgatcttctc cagatgcaca gtcaccacct tgccgtcctc   1020
 aatgagccac gagctctcct ccgccttcac ttcgttgtag agctccccat cgatgatcgc   1080
 tggctgcccc ttgagcccca ccaccacgtc cttccctttc agctggaagt ccacacagaa   1140
 agggaccgcc aggtccagct ccgacagggt cttggtccag cggtaatcag gcaggtctgc   1200
 cctgttgcct aggttgggct tcagttttcc tttgtccttc tcatcttcct cctcctcatc   1260
 ttcctcagtc ttctgcttcc ctcgccttcc atagagtgaa acatctgatt catcttcata   1320
 attcagtaat tgataagatg aaataccagc tgaaatttct ctgtctccta ggagaatatc   1380
 tttcagtgta aaaggtgttg aagtaaattt atatctagga aacagaaagc atcgcttctt   1440
 ttttaccacc agacttagag gttgatattt gtcagcttca ctgaggcttg gaacaggaac   1500
 taatctccct ccatctccaa cttgcttgac aaagctcttg gtagcagcag caaacat      1557



      <210> 2225
      <211> 2023
      <212> DNA
      <213> Homo sapiens


      <400> 2225
 tttttttttt ttgaaggcaa aagtgtttat tcaagacttt ctaccacact gtgggaagca     60
 tcgataaaca gtcataataa ttatcattct gagtcactgc aagcgtgggg ttggatgctg    120
 gctctcacag tagcctgtgt tgggaccatg agcagccatg cgcacctcca cgcacggccg    180
 agctcaaccc gaagaccacg cgtgctccct ggcaggagca ggaggcctga ccacagacgc    240
 agcagctccc cagcctgagc ctgggagtgc accagccagc tcgcagcgga ggccgtttct    300
 cctcacaggc tggagtgagc tcagagtcta gaggtcagag gacctcagac taagagctgc    360
 aacagaacga cagcaagaac attctggaaa cgatgccaca gtgaatcttt tatactgtca    420
 ctcacacttg gtgagggcct cagacatgaa accctgggga gaggcgagtg tgacctccag    480
 agtttggctg ggatgcggct gagacagacc tgctgctggc cgaggagggc agtggctggc    540
 gtggccctca tggccagcag gtgctaggac tcctctggag gcccaggcgc ctgtctaagc    600
 tgccggctgt ggaccacctg cagagctccc cccgcagcct ggcggagctg ggcatccagg    660
 gcgccacgga ggtcgttcac ctggacatca ggcagggggt taaggccaat gatgacccca    720
 tccctcgggg ccagctgacc ctctgcatga gggccaaggt cccgccgtcg cctccggagg    780
 tcggagccag cctgcagttt caggtcccgg ttgggcttgg cattgtccgg cctctggccc    840
 cccgggacag ctcgtttgag ccccagctct ggctctggcc tctgcctggg ctcctggaca    900
 gcagcgtcct ccccgcctct cggctgctcg tgggacacag gcacatggtc ccccccgcgg    960
 gcctttctca tctccaggtg accgccatgg tccagccggt ggccctgctg tccaccctgc   1020
 tcgccatcag agatgacccg cagttccggc tggcgtaaca cagcctgggg ctgtgcagct   1080
 gctccttccg ccccaccggg caggtccgct gcaaggccca ggtctcggct cacttgcttg   1140
 ggcttcatgc gagggtcccc cgtctctgct cctggccctg ccacgagcca gttggcttcc   1200
 ttcagaatgc tggtgccagt ggctgccacc tccttcccag gttttttcct gtcttgggaa   1260
 ccgccagtaa cgtcctgact ttgcccaggg aattcctctg cgaggcgctc ctctgggccc   1320
 ccggcttccc tggcggggtc tggcacgggc acctgctccg ggcccttggg gagctccttc   1380
 acagtgccag ctgccctggg ggcggcatcc ttctggccat ctctcagctt gccctgggct   1440
 gcccgaggct ctgtgtcagg gccgccgtca ggagggccag cagggtctct gcccacaggc   1500
 ccctcagagt gctccaggga gcgctggtta aggtcctggg atggagcagg gcggccccca   1560
 ggagctctga ggacagggtc caaaggcagg ggaggcagat tctccaccgt ctccctggcc   1620
 ttgccttcag gggcctcctg gcctctgggc accgctgccc cgggctcttg atgcacctcc   1680
 acctgcctgg gtttatcctc ctcgtcctcc tgcctctgct ggtggatctc cttgtgctgc   1740
 tcctcgatca ccgccagcag cttctcctgc tggtccagca agcgcttttg ctgcacctgc   1800
 tgttctttga tcacctgaag caggacggcg tggtccagca tctccgccct gccagcttcc   1860
 tccagctggc tggccgcctg gtttccaccc gctcgctcca cgtccctctg ctcgcgaggc   1920
 tcgggcgggc agcccaggcc ctggagccgg cttctccgct gggaggggag gcttcccacc   1980
 gtggtcgctg tcctctgcgg gctgccctgt gtccccggcg gcg                     2023



      <210> 2226
      <211> 933
      <212> DNA
      <213> Homo sapiens


      <400> 2226
 tctgccagcc ctacccacgg ccccggcccc gcaccgggac acatggaagc tgccagcccc     60
 ccagccaagg atcagctgag ccctagggct gatgcttgcc tacgttgctg agaatggcac    120
 tgaaggccca gccaacaaag gttaacccca ggacactcct ggacagtgat cctgatgtct    180
 gttgtgagct gcacactcaa gggtgttgat aaccagcccc agtcgggcgc catggcgtct    240
 gccgagcccc tgacggcgct gtcccgctgg tacctgtatg ccatccacgg ctacttctgc    300
 gaggtgatgt tcacagcggc ctgggagttc gtggtgaact tgaactggaa gttccctggg    360
 gtcacaagcc tgcgggccct cttcatctac ggcaccacca tcctcatcgt ggagcgcatg    420
 tacctgcggc tgcgcggccg ctgcccgctg ctcctgcgct gcctcatcta cacgctctgg    480
 acctacctgt gggagttcac caccggcttc atcctgcgcc agttcaacgc ctgcccctgg    540
 gactactccc agttcgactt tgacttcatg ggcctcatca ccctggagta cgccgtgccc    600
 tggttctgcg gggccctcat catggagcag ttcatcatcc gcaacaccct ccgcctccgc    660
 ttcgacaagg acgctgagcc cggggagccc agcggcgccc tagccctggc caacggcact    720
 gtcaagactg actgagcagg aagcggtgtg gggggcctgg gggatctctc atgggaactc    780
 atgggacaaa gagaccaagc tggtgaggtt gccccatcca tgcagcaaaa gcccttgctt    840
 ccggccaagc cttcagccct atagggcaca cagagccccc taacgtccgc gggggccggt    900
 gttggggggc cgtggtcagg tgttggggga tgg                                 933



      <210> 2227
      <211> 823
      <212> DNA
      <213> Homo sapiens


      <400> 2227
 ggaattccac tggccttcct ctcggaggga caaggaagcg tggcctccct ttcactcacc     60
 ttacttttcc ttctggtcca gggccagctc ttccgaggct ccagcctgct tttccgccgg    120
 gtgtcatcag gatcatgctt tgccctggag taacctgaat catctaaaaa acacggtctc    180
 aacctggcca ccgtgggtga ggcctgacca ccttgggaca cctgcaagac gactccaacc    240
 caacaacaac cagatgtgct ccagcccagc cgggcttcag ttccatattt gccatgtgtc    300
 tgtccagatg tggggttgag cgggggtggg gctgcaccca gtggattggg tcacccggca    360
 gacctaggga aggtgaggcg aggtggggag ttggcagaat ccccatacct cgcagatttg    420
 ctgagtctgt cttgtgcaga gggccagaga atggcttatg ggggcccagg ttggatgggg    480
 aaaggctaat ggggtcagac cccaccccgt ctacccctcc agtcagccca gcgcccatcc    540
 tgcagctcag ctgggagcat cattctcctg ctttgtacat agggtgtggt cccctggcac    600
 gtggccacca tcatgtctag gcctatgcta ggaggcaaat ggccaggctc tgcctgtgtt    660
 tttctcaaca ctacttttct gatatgaggg cagcacctgc ctctgaatgg gaaatcatgc    720
 aactactcag aatgtgtcct cctcatctaa tgctcatctg tttaatggtg atgcctcgcg    780
 tacaggatct gggtacctgt gcaattttga aaacccattg gtt                      823



      <210> 2228
      <211> 1610
      <212> DNA
      <213> Homo sapiens


      <400> 2228
 gcctcctcct cagctcgcct ggcttctcac ttaggcgtgt gctttcgctt tgcagcaaaa     60
 gctgctgctt ttcgcatcta aattcttgct ctgaaggtgc caagaacctg gaaaccggct    120
 gggagtgggg tctcaccagc ctttggagac cctcctgagc cgtctggcaa ccagtgacga    180
 tacagagctg cacggaacgt catgaaggac caacgcctgg ttttccatag taaagttagg    240
 tcatctggtt atgcgtcagc accacatgta actatgtttt caccaaagac caacatcaag    300
 agtgagggga aaggatcttc aaggagcagg agcagctgcg cacgggaggc ataccccgtg    360
 gagtgcgctg tgcccaccaa gcccggcccc caggtcgctg ccgcccccac ctgcacacgt    420
 gtatgctgca tccagtactc aggagatggg cagtggctgg cctgtgggtt ggccaaccat    480
 ctgttactcg tttttgatgc cagcctgact gggacacctg ctgtgttttc aggtcacgac    540
 ggggcagtga atgccgtgtg ctggagccag gaccggaggt ggctgctctc tgcggcccgg    600
 gacgggaccc tgcgaatgtg gtcggctcgt ggggcagagc tcgcactgct tctgatataa    660
 acagaagagc aagtccaagc tgatttgcag gctctccacg acgggtgcag tagacatgac    720
 cagtttatcg gcagtcaacg acttttattc ccacatcgta ctcgcagctg gccggaacag    780
 gaccgtggaa gtgtttgacc tcaacgccgg ctgcagtgca gcggtgatag tggaagccca    840
 ctcacggcct gtccatcaaa tctgccaaaa taaaggttca tcatttacaa cccaacagcc    900
 tcaggcttat aaccttttcc tgaccacggc cattggcgat gggatgagac tgtgggacct    960
 gagaaccctg aggtgtgagc gccactttga agggcatcca acccgcggct atccatgtgg   1020
 aatcgctttc agtccttgtg gacgattcgc ggcttgtggg gccgaggaca gacacgctta   1080
 cgtgtatgaa atgggctcaa gcacgttttc tcaccggctg gctgggcaca cagacactgt   1140
 cactggagtg gccttcaacc catcagcgcc ccagcttgcc acagctacct tggatggtaa   1200
 actccagctc tttctagctg agtaaccact gacctgtgag ctgggtccag gaatgctgtg   1260
 aggaacaact taaaagtaag aagtagtggt tcatccatca gggggccaga agcagcaact   1320
 gtttttcata ttttgagact tgcctcagat ttcccccgtt tgcaagctcc tcccctctgt   1380
 gtgtgccatg tcagagtttt atgtctttct gctcctcaaa agggatcccc cttcattggg   1440
 aaaatggaaa tggcgtccag tacttctgca cagaatttgg taaagttaaa acaaaatatc   1500
 tttcaataaa acataatata gtatttgttt gataattaga gttggaagaa aaaagagaga   1560
 atttcttttg ggcagtgaaa ataaagcagt taacagtcaa aaaaaaaaaa              1610



      <210> 2229
      <211> 3806
      <212> DNA
      <213> Homo sapiens


      <400> 2229
 tgtgccccag cctggatatt cgctcagagg tggcagagct tcgtcagctg gagaactgca     60
 gcgtggtgga gggccacctg cagatcctgc tcatgttcac agccaccggg gaggacttcc    120
 gcggcctcag cttccctcgc ctcacccagg tcaccgacta cctgctgctc ttccgtgtct    180
 acggactgga gagcctgcgc gacctcttcc ccaacctagc agtcatccgc gggacgcgcc    240
 tcttcctggg ctatgcactg gtcatctttg agatgccaca tctgcgtgac gtggcactgc    300
 ctgcacttgg ggccgtgctg cgtggggctg tgcgtgtgga gaagaaccag gagctctgcc    360
 acctctccac cattgactgg ggactgctgc agccagcacc tggcgccaac cacatcgtgg    420
 gcaacaagct gggcgaggag tgtgctgacg tgtgccctgg tgtgctgggt gctgctggtg    480
 agccctgtgc caagaccacc ttcagcgggc acactgacta cagatgctgg acctccagcc    540
 actgccagag agtgtgcccc tgcccccatg ggatggcttg cacagcgagg ggcgagtgct    600
 gccacaccga atgcctgggg ggctgcagcc agccagaaga ccctcgtgcc tgtgtagctt    660
 gccgccacct ctacttccag ggtgcctgcc tgtgggcctg cccgccaggc acctaccagt    720
 atgagtcctg gcgctgtgtc acagctgagc gctgtgccag cctgcactct gtgcccggcc    780
 gtgcctccac cttcggcata caccagggca gttgcctggc ccagtgccct tctggcttca    840
 cccgtaatag cagcagcata ttctgccaca agtgcgaggg gctgtgccct aaagagtgca    900
 aggtaggcac caagaccatc gactccatcc aggcggcaca ggatcttgtg ggctgcacgc    960
 atgtggaggg aagcctcatc ctcaaccttc gccagggcta caacctggag ccacagctgc   1020
 agcacagcct ggggctggta gaaaccatta ctggcttcct caaaatcaag cactcctttg   1080
 ccctcgtgtc cctgggcttt ttcaagaacc tcaaactaat ccggggagac gccatggtgg   1140
 atgggaacta cactctctac gtgctggaca accagaacct acaacagcta gggtcctggg   1200
 tggccgcggg gctcaccatt cccgtgggca agatctactt cgccttcaac ccgcgcctct   1260
 gcttggaaca catctaccga ctggaggagg tgacaggcac gcgaggtcgg cagaacaagg   1320
 ctgagatcaa cccccgcacc aacggagacc gcgccgcctg ccagactcgc accctgcgct   1380
 tcgtgtccaa cgtgacggag gcagaccgca tcctgctacg ctgggagcgc tatgagccac   1440
 tggaggcccg cgacctgctc agcttcatcg tgtactacaa ggagtcccca ttccagaacg   1500
 ccacagagca cgtgggtcca gatgcttgtg gaacccagag ctggaacctg ctggatgtgg   1560
 agctgcccct aagccgcacc caggagccag gggtgaccct agcctccctc aagccttgga   1620
 cacagtacgc agtgtttgtg cgggccatca cgctaaccac tgaggaggac agccctcatc   1680
 aaggagccca gagtcccatc gtctacctcc gaacgctgcc tgcagctccc acggtgcccc   1740
 aagacgtcat ctccacgtcc aactcctcct cccacctcct ggtgcgctgg aagccaccga   1800
 cccagcgcaa tgggaacctc acctactacc tggtgctgtg gcagcggctg gcagaggacg   1860
 gcgacctcta cctcaatgac tactgccacc gcggcttgcg gctgcccacc agcaacaacg   1920
 atccgcgctt cgacggcgaa gacggggatc ctgaggccga gatggagtcc gactgctgcc   1980
 cttgccagca cccacctcct ggtcaggttc tgcccccgct ggaggcgcaa gaggcctcgt   2040
 tccagaagaa gtttgaaaac tttctacaca acgcgatcac catccccata tccccttgga   2100
 aggtgacgtc catcaacaag agcccccaaa gggactcagg gcggcaccgc cgggcagctg   2160
 ggcccctccg gctggggggc aacagctcgg atttcgagat ccaggaggac aaggtgcccc   2220
 gtgagcgagc ggtgctgagc ggcctgcgcc acttcacgga ataccggatc gacatccatg   2280
 cctgcaacca cgcggcgcac accgtgggct gcagcgccgc caccttcgtc tttgcgcgca   2340
 ccatgcccca cagagaggct gatggtattc caggaaaggt ggcctgggag gcctccagca   2400
 agaacagtgt ccttctgcgc tggctcgagc caccagaccc caacggactc atcctcaagt   2460
 acgaaatcaa gtaccgccgc ttgggagagg aggccacagt gctgtgtgtg tcccgtcttc   2520
 gatatgcgaa gtttggggga gtccacctgg ccctgctgcc ccctggaaac tactctgcca   2580
 gggttagggc aacctcactg gctggcaatg gctcttggac agacagtgtt gccttctaca   2640
 tccttggccc agaggaggag gatgctgggg ggctgcatgt cctcctcact gccacccctg   2700
 tggggctcac gctgctcatc gttcttgctg cccttggttt cttctacggc aagaagagaa   2760
 acagaaccct gtatgcttct gtgaatccag agtacttcag cgcctctgat atgtatgtcc   2820
 ctgatgaatg ggaggtgcct cgggagcaga tctcgataat ccgggaactg ggccagggct   2880
 cttttgggat ggtatatgag gggctggcac gaggacttga ggctggagag gagtccacac   2940
 ccgtggccct gaagacggtg aatgagctgg ccagcccacg ggaatgcatt gagttcctca   3000
 aggaagcttc tgtcatgaaa gccttcaagt gtcaccatgt ggtgcgtctc ctgggtgtgg   3060
 tatctcaggg ccagccaact ctggtcatca tggagttaat gacccgtggg gacctcaaga   3120
 gccatcttcg atctttgcgg cctgaggcag agaacaaccc tgggctccca cagccagcat   3180
 tgggggaaat gatccaaatg gctggtgaga ttgcagacgg catggcctac cttgctgcca   3240
 acaagtttgt gcaccgagat ctagcagccc gcaactgcat ggtgtcccag gacttcaccg   3300
 tcaagatcgg ggacttcggg atgactcggg acgtgtatga gacagactat taccgcaagg   3360
 gtgggaaggg gctgctgccc gtgcgctgga tggcccccga gtccctcaaa gatgggatct   3420
 tcaccaccca ctcggatgtc tggtcctttg gcgtggtact ctgggagatt gtgaccctgg   3480
 cagaacaacc ctaccagggc ctgtccaatg agcaggtgct gaagttcgtc atggatggcg   3540
 gggtcctgga ggagctggag ggctgtcccc ttcagctgca ggagctgatg agccgctgct   3600
 ggcagccgaa cccacgcctg cgcccatctt tcacacacat tctggacagc atacaggagg   3660
 agctgcggcc ctccttccgc ctcctctcct tctactacag cccggaatgc cggggggccc   3720
 ggggctccct gcctaccacc gatgcagagc ctgactcctc acccactcca agagactgca   3780
 gccctcaaaa tgggggtcca gggcac                                        3806



      <210> 2230
      <211> 6140
      <212> DNA
      <213> Homo sapiens


      <400> 2230
 cactgccagt ggtcaagggt ctgttaagta tgatagcacc gatcaaggat caccagcctc     60
 caccccctct actacacggc ccctcaactc tgtggagccc gccaccatgc agccaattcc    120
 cgaagcccac agcctctatg ttaccctgat tctctccgat tccgtgatga atatctttaa    180
 agacagaaac tttgacagct gttgcatctg tgcctgcaac atgaacatca aaggggcgga    240
 tgtcgggctt tacatccccg attcttccaa tgaggaccag taccgctgta cctgtgggtt    300
 tagtgcgatt atgaaccgca aacttggcta caattcagga ctcttccttg aagatgagtt    360
 ggatattttt gggaagaatt ctgatattgg tcaggctgca gagaggcgct taatgatgtg    420
 tcagtccacc ttccttcctc aggtggaagg aaccaaaaaa ccccaggagc cacccataag    480
 ccttctcctc ctcctccaga atcaacacac acaacctttt gcttcactga atttcctgga    540
 ctacatttcc tctaacaatc gccaaactct tccctgtgta agctggagtt atgaccgggt    600
 gcaagcagat aataatgatt actggacgga atgctttaat gcgttggagc aggggcggca    660
 gtatgtggat aaccccactg gtggaaaagt ggacgaagct ctggtgagaa gtgccactgt    720
 gcactcttgg cctcacagca atgtgctgga catcagcatg ctctcctccc aggatgtggt    780
 tcgtatgctg ttgtccctgc agccctttct ccaagatgcc atccaaaaga agcgcacggg    840
 caggacctgg gagaacatcc agcatgtgca gggaccactc acttggcagc agttccataa    900
 aatggcagga cggggaacct acggttcgga agaatctcct gagccgttgc ccatccccac    960
 tctgctggta ggctatgaca aggatttcct caccatctcg ccattctcct tgccgttttg   1020
 ggagaggctc ttgttggacc catatggggg ccaccgtgat gttgcctata ttgtggtgtg   1080
 tccagaaaat gaggccttgc tcgaaggagc caaaactttc ttcagggact tgagtgctgt   1140
 atacgagatg tgtaggcttg ggcagcacaa gcccatctgc aaagtgctac gtgacgggat   1200
 catgcgcgtg ggaaaaactg tggcacagaa gctgacagat gagcttgtga gtgagtggtt   1260
 taaccagcct tggagcggcg aggagaatga caatcattcc agactcaaac tttatgcgca   1320
 agtttgccgc catcacctag caccttattt agccactctg cagcttgata gcagcctatt   1380
 gataccacct aaataccaga ccccaccagc agcagcacag ggacaagcta cgccagggaa   1440
 tgctgggccc ttagctccaa atggatcagc agctccccca gctggcagtg catttaatcc   1500
 cacctcgaat agtagttcta caaatcctgc agcaagtagt tctgcatctg gttcctctgt   1560
 gccaccggtc tcatcgtctg cctctgctcc tggtattagc cagataagca ctacctcttc   1620
 ttcaggattc agtggtagtg ttggagggca gaaccccagc actgggggca tttctgcgga   1680
 tagaacgcaa gggaacatag gctgtggtgg agacactgac cctgggcaga gctcttctca   1740
 gccctcacag gatggacaag agagtgttac agaaagggag agaataggaa ttcccacgga   1800
 gcctgactct gcagacagcc atgcccaccc tccagctgtt gtcatttaca tggtggaccc   1860
 gttcacgtat gctgcagagg aggactccac ttctgggaac ttttggctgt tgagcttgat   1920
 gcgctgctac acagaaatgc tggataattt acctgagcat atgagaaatt ctttcattct   1980
 ccagattgtg ccttgccagt acatgctgca gacaatgaag gatgagcaag ttttctacat   2040
 tcaatacttg aagtccatgg cattttcagt gtactgccag tgcaggcgac cactgcctac   2100
 acagatccac attaaatccc tcacgggatt tgggcctgca gccagcattg agatgaccct   2160
 caagaaccct gagcggccca gcccaatcca gctttactcc cctcccttta tattggcccc   2220
 aatcaaagac aagcagacag agctgggaga gacgtttggt gaggcgagcc agaaatacaa   2280
 tgtgctcttc gtgggctatt gtctgtctca cgaccagcgc tggcttttgg cttcctgcac   2340
 tgacctccat ggggaattat tagagacctg cgttgtaaat attgctttac caaacaggtc   2400
 acggaggagt aaagtatctg cacgtaaaat tggactacag aagttatggg agtggtgcat   2460
 agggattgtc caaatgacat ctctaccctg gagagttgta atcgggcgac ttgggcgtct   2520
 tggccatggg gagcttaaag attggagtat cctccttgga gaatgttcac tacagacaat   2580
 cagcaaaaag ctcaaggatg tgtgccggat gtgtggaatc tctgccgcag actctccttc   2640
 tatccttagt gcctgcctgg ttgccatgga gccccagggg tcctttgtag tgatgccaga   2700
 tgctgtcaca atgggctctg tttttggccg aagtactgca ctgaacatgc agtcatctca   2760
 gctcaacacc cctcaagatg cttcttgtac acacatcttg gtgttcccaa catcatcaac   2820
 catccaggtg gctccagcca actaccccaa tgaagatggg tttagcccca acaatgatga   2880
 tatgtttgtt gaccttccat tcccagatga tatggacaat gatattggca tattaatgac   2940
 tgggaacctc cattcctctc ccaactcttc cccagtaccc tccccaggct ctccttctgg   3000
 aattggtgtg ggctctcact tccagcatag tcggagccag ggtgagcgtc ttctttctag   3060
 agaagcacca gaggagctaa agcagcagcc cctggccctt gggtattttg tatcaactgc   3120
 caaagctgag aatcttcccc agtggttttg gtcatcgtgt ccccaggctc aaaaccgagt   3180
 gccctctctt cttaaaggct tcgctgcatc accacatttc agtagcacag acagacgaac   3240
 ttctgcctgc caggaattct cagcgggttc cacaccctct tgactccaaa accacgtcgg   3300
 atgttttaag gtttgttttg gagcagtaca acgctctgtc ctggctcacg tgcaatccgg   3360
 ccacccagga ccgtacttcc tgccttcccg tccactttgt ggtgctcact cagttgtaca   3420
 atgccatcat gaatatactt taattggaaa agcacttgtt ctctctggct cagttccttc   3480
 tccctgcaac ctcagtccaa ggaacctgct acactctgca aataacccac atccttttct   3540
 tcagaccact ctccacagtc ctgcactgtg attccttctc agcaggcaca tgtcaattct   3600
 gcagtgttca ttaccagagt gactccttga cacttctctc atggacctgg aaacttccat   3660
 aagtggtgac tttcagccag tgcggtggtg tgtgtagccc caaccactgg tccccaggaa   3720
 gtggtggtgg ttgatggctt ttcagcggga aacagaagag acagtgtcct tttgcacaag   3780
 agtctgtgtt ttcagcctct gtatacaatt gagggcagtc tagccctttg gatgaaatcc   3840
 tcttagttac tggtgtatgg cctgtgggtt acctgaactc cataatctgg gactttttaa   3900
 aaataagaac cagctcaagt acatggtttc atactggggt ttctgtctcc ctagtgttcc   3960
 catccagatt accatgagtg ctttggttga cttcaaacct gtgtgtcaat gcagaaggtc   4020
 tggagacagc ttcattttgt ttatttattt taatttgttt tgtcatatgg tttttgtgac   4080
 tttatttttt taattcacaa ggaccaggta cagtagctga aacccaattc agatccacca   4140
 taggattctt tgactacata cctctgtcct agaagccgga aaaggagtaa aaacacattg   4200
 gggagatcat gcctaaaagt aatatattca aaaccaccca gcagtaggtt ttgttaacaa   4260
 caaactggat tttaaaagtt ctgccatgtt aagtggccag catttcatga aggataacat   4320
 ttttatacag aaggcagtca agctcaactc agagccatgg aggcaagtac cttaattagt   4380
 tttatatagt cacaacggaa atatattttc tagtgaattc ttattggaag ccaggtctct   4440
 cctctcatta gatcaaaagg gacttatgta catacaacaa ttgaaagtgt ttgctcatga   4500
 aatcagttat aaatatggtg aattttttct ggaccatagg aatattattt caaagaaata   4560
 ttacaactta accattaaat tagtacttga agttgagcct ttgtggtggg actttttaaa   4620
 aaaatgcctt tttaaagcat taatggctaa ttgaagtatt ttatgactcc tcattcctgg   4680
 cccagagggt tgtctttgaa accctgtttc taacccttgt gttgtgtgtt tctgtctgag   4740
 gacagtgggt gtgtactggc ctcccgggag ccactgtgac caggcctttg agctcttgtc   4800
 atctgtggag agaatcatgc aaattttaaa agttcttcca agagacttcc atgtcctggt   4860
 tattaacaaa aaaggaaaaa tgtaataatt gatatgattt tgtaaaagta tttttcttga   4920
 aataatctaa agtttaaaac attatattaa aaaaaaagtt gtgtggtggg aatgtgaaag   4980
 cagagaaata acttgtaaat ggataatttt gttctctgta ccaccagttg aagggggggt   5040
 tgactttcgc aatgtatagg ataaaaaatc tgatatatca aaccatttgt atctaatgtg   5100
 tacagtgtaa aattgacttt aaaaatattg cagtgctatt ttttcttaat cagaaaggaa   5160
 aattctcaag gccttttgaa gagcataaga agatgaagat tgtaaacttg tataaaatta   5220
 tcttggtgag aagacaaatt gtaaagtaga tatttgtaat cttttaccac tttggggttg   5280
 cttttttccc ggaattcatc agaactttga attttttttt taaatgggct gtttttaatg   5340
 caggggcttt tcttccctag aaacccaatt ctaagcagaa aaagaaaaaa aacacaaaaa   5400
 ataaaaaacc cctacaaaaa aactttaaaa aaaatggcag caaagggtag ttttcatctg   5460
 gtgtctttta tttaagtttt ttaagttaag aaaagctggt gacatattta tacgtttttg   5520
 tgcaaaaata aatgaatggc aatagatttt aaaaaatctt attatgtact tctgtgtgaa   5580
 aaagtctgta taatatttcc cttaaatatg cattatttta cttgtgagtt ttttactgaa   5640
 ttaatctgaa atgtacaagc cctggatttg ctacagagtg agaagttatt ttattttttt   5700
 ttatttttaa ttttggaaat tctgcagaaa tcagaactct taccatggtt tgaacaaaaa   5760
 aaggggaaat ggggagggga aaagggtggg attgtccagc atgcttgtat gtatatttca   5820
 gaaccttttt taaatgtaaa agctgtacat ttctgggaag ttctgaattt cttttgtttc   5880
 cttttttcct tcaagcattt tgcagtgagc ttcttttata tatagcaaac aatttgaaag   5940
 aatacaaaaa tatgtgaagt tcatttaaaa aaataactac agtatagcgc tggtacagta   6000
 cactaaaaga ctttgataaa aagaaacaat aataaaaggc ctccatttta aatgtcattc   6060
 atatatacct tgtggatgag agctatatac ttttacacac ttttttagag gaataaatta   6120
 ttgaattact aaaaaaaaaa                                               6140



      <210> 2231
      <211> 1795
      <212> DNA
      <213> Homo sapiens


      <400> 2231
 ggctcgggct cggctccggg acgctgctct ccgtgtccga gtacaagaag aagtaccggg     60
 agcacgtgct gcagctgcac gctcgggtga aggagaggaa cgcccgctcc gtgaagatca    120
 ccaagcgctt caccaagctg ctcatcgcgc ccgagagcgc cgccccggag gaggcgctgg    180
 ggcccgcgga agagcctgag ccggggcgcg cgcggcgctc ggacacgcac actttcaacc    240
 gcctcttccg ccgcgacgag gagggccggc ggccgctgac cgtggtgctg cagggcccgg    300
 cgggcatcgg caagaccatg gcggccaaaa agatcctgta cgactgggcg gcgggcaagc    360
 tgtaccaggg ccaggtggac ttcgccttct tcatgccctg cggcgagctg ctggagaggc    420
 cgggcacgcg cagcctggct gacctgatcc tggaccagtg ccccgaccgc ggcgcgccgg    480
 tgccgcagat gctggcccag ccgcagcggc tgctcttcat cctggacggc gcggacgagc    540
 tgccggcgct ggggggcccc gaggccgcgc cctgcacaga ccccttcgag gcggcgagcg    600
 gcgcgcgggt gctaggcggg ctgctgagca aggcgctgct gcccacggcc ctcctgctgg    660
 tgaccacgcg cgccgccgcc cccgggaggc tgcagggccg cctgtgttcc ccgcagtgcg    720
 ccgaggtgcg cggcttctcc gacaaggaca agaagaagta tttctacaag ttcttccggg    780
 atgagaggag ggccgagcgc gcctaccgct tcgtgaagga gaacgagacg ctgttcgcgc    840
 tgtgcttcgt gcccttcgtg tgctggatcg tgtgcaccgt gctgcgccag cagctggagc    900
 tcggtcggga cctgtcgcgc acgtccaaga ccaccacgtc agtgtacctg cttttcatca    960
 ccagcgttct gagctcggct ccggtagccg acgggccccg gttgcagggc gacctgcgca   1020
 atctgtgccg cctggcccgc gagggcgtcc tcggacgcag ggcgcagttt gccgagaagg   1080
 aactggagca actggagctt cgtggctcca aagtgcagac gctgtttctc agcaaaaagg   1140
 agctgccggg cgtgctggag acagaggtca cctaccagtt catcgaccag agcttccagg   1200
 agttcctcgc ggcactgtcc tacctgctgg aggacggcgg ggtgcccagg accgcggctg   1260
 gcggcgttgg gacactcctg cgtggggacg cccagccgca cagccacttg gtgctcacca   1320
 cgcgcttcct cttcggactg ctgagcgcgg agcggatgcg cgacatcgag cgccacttcg   1380
 gctgcatggt ttcagagcgt gtgaagcagg aggccctgcg gtgggtgcag ggacagggac   1440
 agggctgccc cggagtggca ccagaggtga ccgagggggc caaagggctc gaggacaccg   1500
 aagagccaga ggaggaggag gagggagagg agcccaacta cccactggag ttgctgtact   1560
 gcctgtacga gacgcaggag gacgcgtttg tgcgccaagc cctgtgccgg ttcccggagc   1620
 tggcgctgca gcgagtgcgc ttctgccgca tggacgtggc tgttctgagc tactgcgtga   1680
 ggtgctgccc tgctggacag gcactgcggc tgatcagctg cagattggtt gctgcgcagg   1740
 agaagaagaa gaagagcctg gggaagcggc tccaggccag cctgggtggc ggcag        1795



      <210> 2232
      <211> 574
      <212> DNA
      <213> Homo sapiens


      <400> 2232
 gtaacccagt atatacctaa cagaaggtgg tgaaatacat cttcatacat ctactcagtg     60
 aaatactagc cagcctctgt gagctggagg gcagcacctg ggaagaggac tcctcggatg    120
 gggctgctcc tgagcccata gggctcagtg tagtgatcct gctcggctgg ccacgaagtg    180
 tcagagtaat ggtggtgggg accttcaagc ctgggaggga gctgccagga gatgtggcca    240
 ccaggcggct ctgcagtgtg tgcaaggcac tgggtgcagt gctgctggag accactgaag    300
 ggactgggct ggctgagatt gtcatcagct cccccaacca ccaccaagct gttctcagct    360
 cgaatcttct cccggaagtc ctccatggct tcagggtgac attgaaggga attctgacca    420
 atgacaaaga ggactggagt cttcatatcc aagaggggat catctacatc ccctctgggg    480
 ccatccacag taagcagagg aaacccaagg cagacaactg cagtgacata ctccattact    540
 gacacatgac aggccaccaa agctcctgtg ttcc                                574



      <210> 2233
      <211> 561
      <212> DNA
      <213> Homo sapiens


      <400> 2233
 actattttct aaattctgtg ctaacagaac cggcttcagc tgaagaaaga gaggaatgaa     60
 gcgccttctg cttctggttt tgatctttat aacattttct tctgcatttc ccttagtccg    120
 gatgatggaa aatgaagaaa atgtgcaact ggctcagaat aataaactat actccggata    180
 tggcacgagc tgctgtggat gaggctatcc aagaaggttt agaagtgtgg agcaaagtca    240
 ctccactaaa attcaccaag atttcaaagg ggattgcaga catcatgatt gcctttagga    300
 ctcgagtcca tggtcggtgt cctcgctatt ttgatggtcc cttgggagtg cttggccatg    360
 cctttcctcc tggtccgggt ctgggtggtg acactcattt tgatgaggat gaaaactgga    420
 ccaaggatgg agcagatctc catgacaatt ctccctttta tggacatgat ggttgtcttg    480
 ctcatgcatt cccacctgga ccaggtatcg gaggagatgt tcattttgat aatgatgaaa    540
 caaggaccaa ggatttcaga a                                              561



      <210> 2234
      <211> 406
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> misc_feature
      <222> (1)...(406)
      <223> n = a,t,c or g


      <400> 2234
 ggaaggctgt tttcaaaaga tcaagcttga ccacatatta tcccctccac ccatgccgtt     60
 ttggaaatgc agcaacccag atgtggcttt tggccctgga aaatccctga agtataaaag    120
 acagctgagt taggatggaa gacagctaag gcgagggagc ctgggaggag ccctgactgg    180
 gaggtacctt cttccaaacc cggtggcggg acaggcctgg ccggcctctg cagagacgtc    240
 caacctcgtg ggcatgcgca gccaggccct gggccagtcg gcgccctcgc tcaccgccag    300
 cctgccctgt gtgtccaaat gctgggagaa catcccccct tggatgaatt gcccccccat    360
 taaataaaac atatccaaag ctcnnnnnnn nnnnnnnnnn nnnnnn                   406



      <210> 2235
      <211> 2440
      <212> DNA
      <213> Homo sapiens


      <400> 2235
 ggtgcaggca ggtgcgatgg gccagcttga ggcacactga ggggacgcgg ggctgggcag     60
 tggcgtgcgc tcgggccgcc gccgccgctg cctcggcggg tcctcggcct cttcaggcaa    120
 ccagccgcct caggagctgg ggcttgggga gctgctggag gagttctccc ggactcagta    180
 ccgggccaag gatggcagcg ggaccggcgg ctctaaggtt gagcgcattg agaagagatg    240
 tctggagctg tttggccgat actactgttt cagcgtgatt ccaaacacga atggggatat    300
 ctgtggccac tatccccggc acatcgtgtt cctggagtat gagagttctg agaaggagaa    360
 agacacgttt gagagtaccg tacaggtgag caagttgcaa gacctcatcc accgcagcaa    420
 gatggcccgg tgcagaggac ggtttgtctg cccagtaatc ctgttcaagg gcaagcacat    480
 ttgcaggtcg gccacactgg ctggatgggg agagctgtat ggacgctcag gctacaacta    540
 ttttttctca gggggtgcag atgatgcctg ggcagatgtg gaggacgtca cggaggagga    600
 ctgtgctctt cgaagtggtg acacgcatct ttttgataag gtcagaggct atgacatcaa    660
 gctgcttcga tacctgtcag tcaaatacat ctgtgacctg atggtggaga acaagaaggt    720
 gaagtttggc atgaatgtaa cctcctctga gaaggtggac aaagcccagc gctatgccga    780
 cttcactctc ctctccatcc cgtatccagg ctgtgaattt ttcaaggaat ataaagatcg    840
 ggattacatg gcagaagggc tcatatttaa ctggaagcag gactacgttg atgccccatt    900
 gagcatcccc gacttcctga ctcactctct gaacattgac tggagccagt atcagtgttg    960
 ggatctggtg caacaaacac aaaactacct gaagctgctg ctttccttag ttaacagtga   1020
 tgatgacagc gggctgctgg tacactgtat ctcaggctgg gatcggaccc ccctcttcat   1080
 ctccctcctg cgcctttcct tgtgggctga tgggctcatc cacacgtccc tgaagcccac   1140
 tgagatcctc tacctcactg tggcctatga ctggttcctc ttcgggcaca tgttggtaga   1200
 tcggctcagc aaaggggagg agattttctt cttctgcttc aattttttga agcatattac   1260
 ctccgaggag ttctctgctc tgaagaccca gaggaggaag agtttgccag cccgggatgg   1320
 aggcttcacc ctggaagaca tctgcatgct gagacgaaag gaccgtggca gcaccaccag   1380
 ccttggcagc gacttctccc tggtcatgga gagttcccca ggagccactg ggagcttcac   1440
 ctatgaggcc gtggagctgg tcccagcagg agcgccaact caggcagctt ggaggaagag   1500
 ccactcatcc tctccacaga gtgtcctctg gaaccggcca caaccctcag aggaccgctt   1560
 gccttcccag caggggctgg cggaagccag gtcttccagc tcctcttcct caaaccattc   1620
 tgataacttt ttcaggatgg gtagcagtcc cctggaggtc cccaaaccca gatcagtgga   1680
 ccatcccctg cccggatcct ctctctccac agactatggc agctggcaga tggtaacggg   1740
 ctgtggcagt attcaggagc gggctgtcct gcacacagac tcctctctcc ctttcagctt   1800
 cccggatgag ctccctaaca gttgtctgct tgcagccctg agtgatcgag agactcggct   1860
 gcaggaggtg cgctcagcct tcttggctgc gtacagcagc acagtggggc ttcgggcagt   1920
 agcccccagt ccttccggtg ccatcggggg cctgctggag caatttgccc gtggtgttgg   1980
 actccggagc atcagcagca atgccttgtg aagaagccag cccatgacat tttcctgctc   2040
 ctctctcagc tgagccctta gcagagaatc aaagccatgc ctggccgaag gggtacttcc   2100
 aggtcagggg aaatttcagt cccccatctc catcatgaac atggcagccc caaagctgag   2160
 caaggccaaa gacagggttt tccaaccccc agcctcttga ctggtgacca ccaccccttc   2220
 ttgtcactgt ctcccaccca ccccatcttt gctgggattc ccatcaactc tcagaactgt   2280
 gtggggtttc cctggggcct tgtggaagcc atgacttcac aaagacccta cctgtcagtt   2340
 cttgtttctg gggaggaggg atcacctgca ctgagaatga ggcagtttga cacagatcac   2400
 aaaataaaat caaagtcttt ttgaatagcc aaaaaaaaaa                         2440



      <210> 2236
      <211> 2423
      <212> DNA
      <213> Homo sapiens


      <400> 2236
 cccaattccc gggtcgacga tttcgtgagt gggcggaggg ggtggaggtt tgtctccgct     60
 gtttcatctc tatggctgtc agaggtgggc ggctttgacc gagaggctgc tggagctcgt    120
 gtttggacgc gatgtttcgt ctgaactcac tttctgcttt ggcagaactg gctgtgggtt    180
 ctcgatggta ccatggagga tcacagccca tccagatccg gcgaagacta atgatggtgg    240
 ctttcctggg agcatctgca gtaactgcaa gtactggtct tttgtggaag agggcccatg    300
 cagaatctcc accatgtgta gacaacctaa aaagtgacat cggtgataaa gggaagaata    360
 aagatgaagg ggatgtttgt aaccatgaga aaaagactgc agatcttgcc cctcacccag    420
 aagagaaaaa gaagaaacgt tctggattca gagacagaaa agtgatggaa tatgagaata    480
 ggattcgagc ctactccacg ccagacaaaa tcttccgata ttttgccacc ttgaaagtca    540
 tcagtgagcc tggtgaagca gaagtgttta tgacaccaga agattttgtg cgatccataa    600
 cacccaatga aaaacaacca gaacacttgg gtctggatca atatataata aaacgctttg    660
 atggaaagac agagaaaatt tcccaggaac gagaaaaatt tgctgatgaa ggcagtatat    720
 tttacaccct tggagaatgt gggctcatat ccttttcaga ttacattttc ctcacaactg    780
 ttctttccac tcctcagaga aattttgaaa ttgccttcaa gatgtttgat ttgaatggag    840
 atggagaagt agatatggaa gaatttgaac aggttcagag catcattcgc tcccaaacca    900
 gtatgggtat gcgccacaga gatcgtccaa ctactggcaa caccctcaag tctggcttgt    960
 gttcagccct cacaacctac ttttttggag ctgatctgaa gggaaagctg acaatcaaaa   1020
 acttcctcga atttcagcgt aaactgcagc atgatgttct gaagcttgag tttgaacgcc   1080
 atgaccctgt ggatgggaga attactgaga ggcagtttgg tggcatgcta cttgcctaca   1140
 gtggggtgca gtccaagaag ctgaccgcca tgcagaggca gctcaagaag cacttcaaag   1200
 aaggaaaggg tctgacattt caggaggtgg agaacttctt tactttccta aagaacatta   1260
 atgatgtgga cactgcattg agtttttacc atatggctgg agcatctctt gataaagtga   1320
 ccatgcagca ggtggccagg acagtggcta aagtggagct ctcagaccac gtgtgtgatg   1380
 tggtgtttgc actctttgac tgtgatggca atggcgaact gagcaataag gaatttgttt   1440
 ccatcatgaa gcaacggctg atgagaggcc tggaaaagcc caaagacatg ggtttcactc   1500
 gcctcatgca ggccatgtgg aaatgtgcac aggaaactgc ctgggacttc gctttaccca   1560
 aacagtaacc ccacactgca agaggggacc cctccacccc cagtaccctg gaccccctcc   1620
 gcagagtctc ggcagagccc tttgtgctgc tgcttctgga agtagtctcc cttcctcccg   1680
 ggatgacctc aggactctgt cggtttcccc tctttaccct tccccgtccc cgtgttctgc   1740
 tgggctctga ttctgcccaa tgagtatccc cataggttct caaaaacatg aacaagtctg   1800
 taaagctcag acatttgtca gcctcaacag caccacccat tcaagcatcc tgtggataaa   1860
 gaattcaggg aaccatccac acacctgcca accctgggaa gcatccagtt ctcaaatcgt   1920
 ttttgctatg gatttatact aacaagaaca ttccttgact tccctcctgc tggtgtttta   1980
 aagccacaag tagggaagat atctggcagg cagaaagaag tctgtgatga taaacaatga   2040
 tgaggatgac ctaggcaccc tacgctagtg tgagaagcct gcgccccagg aaggatctgt   2100
 gttagtccct gggatggctc caaggcctgc tctaggaagg cagcatgctc agtgggaaca   2160
 cagcaagatt cagaatttaa agtagttgct tcatggctct gtgcactccc ttttcttcct   2220
 cgcagcctcc ctaagatgac tccagtgtga ccctgtgctt agtgagcaat agtgattgag   2280
 ctcatgttcc ctgcaagtgc catttcctct ccaggatggg cctctaaagc tgaggcctgg   2340
 ctcagagcct gtttgccctc tgtcttaaac aattgtaaat atcacttaaa ttataaccat   2400
 ttgcaataaa catccccaaa gtt                                           2423



      <210> 2237
      <211> 1452
      <212> DNA
      <213> Homo sapiens


      <400> 2237
 tttttttttt ttccttaaat gaggagattt aatgtcttta cattatacat ttcaaaggaa     60
 caaaacaccc tttatgaatt ttctcatgga gatagcattt acatcacaga gctgttgtga    120
 aaataaaata agaatgtaca gcacacctgg aatataaaaa acatcccaat aacttacttg    180
 gagccccgca gccatccatc cctcacatat aaatacaatg aaccagatga agatccgtgt    240
 ccgtgtccat gacagcaatc cattcagaag atcaaagata aatagtctaa tacaccaatt    300
 tctgacattt gcttagcact gcaggactca tgaagagctg ccactcatat tatctcattt    360
 aatccctaca acaaaaacca aggctcaagg aggtgagtcc ttgcagaaag aacagttaac    420
 agactccaca ggtttgcaaa acagccatat gacagagggc tgaggaagcc tatgatagta    480
 ggctgaggaa gcacagctga actgcagcta tgagactgtt ctagcagcac gactgtggcc    540
 tgaaggcaca ttcttcctcc aggtaaggca agggagctct catggtgact gggcccctcc    600
 tgggcaatgg caatgccact ggagaaacag ctggaaacca tatgctacag ggatgtcttt    660
 tatttgtata ttgatatttc ttcacagaaa attaagcaag tggctattct gtcctggatt    720
 aatccatttg gacttggtcc cattggtgtc cgtggcagct tctgctttgt ctgtaggcac    780
 tggggcctta tcttgtgatg gttatcactt gagggtcttg ctaaggttgg agaaaccaat    840
 gccaacacag gtcatcagca ctttatcccc acccttgagt tcttcaccac atggcttggt    900
 ttcaatttta aacataatct ggaaaaagct cttcaaatgc cgcaaaaatt ctatcgtgta    960
 gggagagaga gggcctagca ggactttgga aacatcctgc tgtccaaggg tcatgagtag   1020
 tagcgccagg ctttggttgg tcgagtatac gcatccaccc ctgtagattt cctccagcag   1080
 cagccgggca cagttcctgc caaggtcctc tggaagtact gctgctccct ggccctgggg   1140
 gttggaggcc agttcagcac tgaggaaggt gccactggtg gtctcagcaa ccagtgacaa   1200
 cccaaagccc ggagacttcc cagagttgac tcctttcatg tgatctgtgt aaatatagat   1260
 atcaggtatg aacttgttga ggatgctcct tgcagaatcc acaatccggt tcgccatctg   1320
 aggtgacaca cgtacagagt acctgcagcc tggagttaag gatgtcattc tgcatacatc   1380
 tctcttcaca tatgcacatt ttgttcttgc tcttcaatga gaccacacac tctataaggg   1440
 caagggcttt ac                                                       1452



      <210> 2238
      <211> 963
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> misc_feature
      <222> (1)...(963)
      <223> n = a,t,c or g


      <400> 2238
 cactatttgt tacagaggat ctttatttat aatgcaaaaa agaaattata aatcccattt     60
 tggactgttt ccgtatctgt aaaacaactt ataaaaaaca gccactccac ctgcaagaag    120
 ttcttgttgg tgcttatggc aggggcatgt gtttgcacag ccctgggggc tgggagggtg    180
 tgtttgtcca gaagagagcc tctccctggg accccaacag ccaggaccat ggcgctccct    240
 ttcaccaggc cggagtcagc aagaacctgg aggtgtcaga ggtccggtcc actcagcggg    300
 gcctgggaaa cactgttctg gaagtggaca ggctggattc ctcgctggtc ctgccacgtc    360
 tctctgagcg gaggcccggg ttcgctcagt tcccatccag ggtattcagc acacctgctc    420
 caggcagcca cgcccccgga cacctgaagc cgggccgctg gagcaggagc cagccagcca    480
 aacccaggac acctcctcag gcttctgggt cgatttctcc atcatctggg cacgaccctg    540
 tctcatccag ccagactgtg ctccccaagt ccctcggcag catcatgccc gtgggggtgg    600
 ggggcgtgat gatgatgtcg ggcacgtcca ggtgcttgtc gttcaggacg ggggcctcgt    660
 cgtggctgct gctgctgctg ctgacacaca tttgaaagcc tgagaagcca ggcgtggagc    720
 acacacgcac gtacacacga cagagagaca ggcatcagtg gccgccggga accgcgggcg    780
 ccaccctccc ttcactatca cctgggtcct gacgcctcgc agcaaggagc gcagctgtcc    840
 ccgcatcaca gatgaaaacc ggcgtctttc aggcaggaca tcttaagccc catgtcggca    900
 cctctgcagg ccgaattcca ccacgctggt ctagggacat cgagntctaa ncctcccggt    960
 cct                                                                  963



      <210> 2239
      <211> 540
      <212> DNA
      <213> Homo sapiens


      <400> 2239
 tgagtcccta gtccgtgtgg tggaattcag acgctgggcc ggcgggcggt ggccgtgcag     60
 agctccgcag acgtctgtgc cacccagagc cggcgggccg ctaggtcccc ggagaccctg    120
 ctatggtgcg tgcgggcgcc gtgggggctc atctccccgc gtccggcttg gatatcttcg    180
 gggacctgaa gaagatgaac aagcgccagc tctattacca ggttttaaac ttcgccatga    240
 tcgtgtcttc tgcactcatg atatggaaag gcttgatcgt gctcacaggc agtgagagcc    300
 ccatcgtggt ggtgctgagt ggcagtatgg agccggcctt tcacagagga gacctcctgt    360
 tcctcacaaa tttccgggaa gacccaatca gagctggtga aatagttgtt tttaaagttg    420
 aaggacgaga cattccaata gttcacagag taatcaaagt tcatgaaaaa gataatggag    480
 acatcaaatt tctgactaaa ggagataata atgaaggtga tgatcgaggc tcgtacaaag    540



      <210> 2240
      <211> 357
      <212> DNA
      <213> Homo sapiens


      <400> 2240
 aaagggacaa acgagggaac agaggcagcc atgtgaacat ggcccttggt gcaaaggagg     60
 gaacagaggg agccacgcgg acacggtcct cagtgcaaac accaccagta agccgagcat    120
 tcacggggga cgtgaaatgt gagcagatgc aggtccagat gtgaaaggga aacacacgag    180
 ctgctagctg acaaagagcg tagcgtctgc tcagaatgct catctcagag gaaataaagg    240
 tttcataaaa caggatacca aaagccggaa ccataaatgg ccagtacaag tatagaacaa    300
 tgctctatta accatcgggt aaatacacga ttagctctta aggaaatacc ttttcat       357



      <210> 2241
      <211> 11178
      <212> DNA
      <213> Homo sapiens


      <400> 2241
 gcacgagact gcgctcgcct ccctcctcac gcgggcggga ttttcttgcc ttgtgaaaaa     60
 ccgtctcggc ggctgccccc gcctcctctg ctggcatgtg aaatggcggt cggcgagtgg    120
 tttgcgtccg tgacatcatc atcatggcaa caagagctgc agcctgggac cgaggagccc    180
 gtgtgattcc cggcggtggc gcagtggcgg cagcaccagc accgacgaaa gcttcgaggg    240
 cttctctcct tgcggcccct tgccgggtgc tcctgaggag gcggcggcag cagcgcctac    300
 accgccccgc ccgccgttcc tcgaggtgcc tctgtgtgag gggagggggc cgtgccgaga    360
 aggggagggg gcgccgccgc cgctgcggag ggagccgccg ccgctgctgc tgccgctgcc    420
 gggtcgccag tgaagggagg cagtggcggc ggcggcgaac atgttttcag taaggatagt    480
 gactgcagac taatacatgg ccagcccgct gcaggggctg gatacctgcc aatcccccct    540
 cacccaggcc cctgtcaaga aggtgccggt ggtgcgagtc ttcggagcga ccccggcaga    600
 ataaaaccca agacaagcca cataaaagca acctaaaaat taaactgtca tcatattatt    660
 tgttttaaaa ctatggaata atatatctga ggaagatttc tctcaaaatt gtttttctca    720
 atttcaagtc agaagacatg tcttcatcta catggcatct ttccttacct ctatgtgcca    780
 tacgatggtt atggacagca gccagaaagc tatctttctc agatggcatt cagtatcgac    840
 agagcactta atgtggcttt aggcaatcca tcttccactg ctcagcatgt gttcaaagtg    900
 tcattagtat caggaatgcc tttttatggt tatcatgaga aggaaagaca ctttatgaag    960
 atctatcttt acaatcctac aatggtgaaa aggatatgtg aacttttgca aagcggagcc   1020
 ataatgaata aattttacca gcctcatgaa gcgcatattc cctacctcct acagctcttc   1080
 attgactaca atctttatgg catgaattta ataaatctgg ctgctgtcaa gttccgaaaa   1140
 gcaagaagga aaagtaatac attgcatgca actggatcct gcaagaatca tttatcagga   1200
 aattctcttg ctgatacttt atttcggtgg gaacaagatg aaataccaag ctctttaata   1260
 ttggaaggtg ttgaaccaca cagtacatgt gaattacaag tggatgctgt agctgctgat   1320
 atcttaaatc gtctggacat tgaagctcaa attggtggaa accctggtct acaggccata   1380
 tgggaagatg aaaagcaacg gcgaagaaac agaaatgaaa cttctcaaat gagccaacct   1440
 gagtcacaag atcacaggtt tgtgccagca acagaaagtg aaaaaaaatt tcagaagaga   1500
 cttcaggaaa ttctcaaaca gaatgatttc tctgtaacat tatcaggatc tgtggactac   1560
 agcgatggat cccaggagtt ctctgctgag ttaacattgc actctgaggt tctgtctcct   1620
 gaaatgcttc agtgtacacc agccaatatg gtagaagttc acaaagacaa agagtcaagc   1680
 aaaggtcaca ctagacacaa agtggaagaa gctcttatta atgaagaagc aattttgaac   1740
 cttatggaaa atagtcagac ttttcagcct ttgacccaaa gactgagtga gtcacctgtt   1800
 ttcatggaca gtagtcctga tgaggctctg gtacatcttc ttgctggttt ggaaagtgat   1860
 ggatatcggg gggaaagaaa taggatgcca tcaccatgtc gctcctttgg aaataataaa   1920
 tatccacaaa atagtgatga tgaagaaaat gaaccacaga ttgaaaaaga ggaaatggag   1980
 cttagtttgg tgatgtccca gagatgggac agcaatattg aagaacattg tgccaaaaag   2040
 agatcactgt gcagaaatac ccacagaagt tcaactgaag atgatgactc atcttcagga   2100
 gaagaaatgg aatggagtga taacagtttg cttctagcca gtctttctat acctcagtta   2160
 gatggaactg cagatgaaaa tagtgacaat ccattgaaca atgaaaattc tagaacccac   2220
 tcttctgtaa ttgcaacaag caagctttca gttaaaccct ccatctttca caaagatgct   2280
 gctacattag aaccctcatc ttctgctaag attacctttc agtgtaaaca cacaagtgcc   2340
 ctttcttccc atgttttgaa caaggaagat ttaattgaag acctttcaca gacaaacaaa   2400
 aatacagaaa aaggtctaga taactcagtc acttctttta caaacgaaag cacttattct   2460
 atgaaatacc ctggatcttt aagcagtact gttcattcag aaaattctca taaagagaat   2520
 agtaagaaag agatcctccc agtatcttcc tgtgaaagta gtatttttga ttatgaagaa   2580
 gatattccat ctgttacaag acaagtacca agtagaaaat atacaaacat tagaaaaatc   2640
 gaaaaggatt ccccttttat acatatgcac cgtcacccta acgagaatac attgggcaaa   2700
 aattctttca acttttctga cttaaatcat tcaaaaaata aagtatcctc tgaaggaaat   2760
 gaaaaaggaa acagcacagc tctgagtagt ttattccctt catcatttac tgaaaattgt   2820
 gaattactgt catgctcagg ggagaataga actatggtgc attctcttaa tagcactgct   2880
 gatgaaagtg gactaaataa acttaaaatt aggtatgaag aatttcaaga acataaaaca   2940
 gaaaagccaa gcctcagcca gcaagcagca cactatatgt tttttcccag tgttgttctt   3000
 tctaactgtc ttactagacc acagaaacta tctcctgtca catataaatt acaacctggc   3060
 aataaaccat cccggttaaa attgaataaa aggaaacttg caggtcatca ggagacttct   3120
 accaaaagta gtgagactgg atccacaaaa gataatttta tacaaaataa tccttgtaat   3180
 agtaatcctg agaaggataa tgcattggct agtgatttaa ctaaaaccac tcgtggagct   3240
 tttgaaaata aaacacccac agatggtttt atagactgtc actttggaga tggaacgtta   3300
 gaaactgagc agtcctttgg actatatgga aataaataca cacttagagc caaacgcaag   3360
 gtaaattatg agactgaaga cagtgagtca agttttgtaa ctcacaactc aaaaattagt   3420
 ctacctcatc ccatggaaat tggtgaaagt ttagatggaa ctctcaaatc ccgaaaacga   3480
 agaaaaatgt ctaaaaagct gccccctgtc atcataaagt atattattat taatagattt   3540
 agagggagaa aaaatatgct tgtgaagcta ggaaaaatag actctaaaga aaaacaagta   3600
 atattaacag aagaaaaaat ggaactatat aaaaagcttg cacctttgaa ggacttttgg   3660
 ccaaaagttc ccgactcccc tgcaaccaaa tatcccattt atccactaac accaaagaaa   3720
 agtcacagaa gaaagtcaaa acataaatct gctaagaaaa aaactggtaa acaacaaagg   3780
 acaaataatg aaaatattaa aagaactttg tctttcagga aaaaacggtc acatgctatt   3840
 ctttctcctc cctcaccatc ttacaatgct gaaaccgaag attgtgactt gaattatagt   3900
 gatgttatgt ctaaactagg ttttctttct gagagaagca caagtcccat aaattcttct   3960
 ccacctcgct gctggtctcc cacagatcca agagctgaag aaatcatggc tgctgcagaa   4020
 aaagaggcaa tgctttttaa gggtcctaat gtatgtaaga agactgttaa ttctcgtata   4080
 ggaaaaacta gtcgcgcaag agcacagatt aagaaatcaa aagcaaagct tgctaatccc   4140
 tctatagtta ctaagaaaag gaacaaacga aatcagacaa ataaactagt agatgatgga   4200
 aaaaagaaac caagagcaaa acaaaaaaca aatgagaaag gtacatcgag aaagcatata   4260
 acacttaagg atgaaaaaat aaaatctcag tctggtgctg aggttaagtt tgtactgaaa   4320
 caccagaatg tgtctgaatt tgcaagtagt tctggaggct ctcaactact ttttaaacag   4380
 aaagatatgc cactaatggg ctctgctgta gatcatcccc tttctgcttc cctacccact   4440
 ggaattaatg cacaacagaa gttatctggc tgcttttctt ctttcttaga aagcaagaag   4500
 tctgtagatt tgcagacatt ccccagttca cgagatgatt tgcatccatc agttgtttgt   4560
 aattctatag gacctggagt ctcaaaaatt aatgttcaaa ggcctcataa tcaaagtgct   4620
 atgtttactc taaaggaatc aacgttaatt caaaaaaata tatttgacct ttccaatcat   4680
 ttatctcagg tagcacagaa tacacagata tcttctggta tgtcctcaaa gatagaagat   4740
 aatgcaaata atatacaaag aaactatttg tcatcaatcg gaaagttaag tgaatatcgc   4800
 aattccctag aatcaaagct ggaccaagca tataccccta attttttgca ttgcaaagac   4860
 agtcagcagc agattgtgtg catagcggaa cagtcaaagc acagtgaaac ttgttctccg   4920
 ggaaatacag cttcagagga aagccaaatg cctaataatt gctttgtaac ttccttgaga   4980
 agtccaatca aacaaatagc atgggagcaa aagcaaaggg gctttatttt agatatgtca   5040
 aattttaaac ctgaaagagt aaaaccgagg tcattatcag aagcaatttc acaaaccaaa   5100
 gcactttctc agtgtaaaaa tcgaaatgtg tcaacacctt cagcatttgg tgaaggacag   5160
 tctggactgg cagttctaaa agaattgtta caaaaaagac agcaggaagc acaaaatgca   5220
 aatactacac aagacccatt atccaataaa catcaaccaa ataaaaatat ttctggttcc   5280
 cttgagcata acaaagcaaa taaacggaca cgatcggtaa cgtccccaag aaaacctcga   5340
 actcccagaa gtacaaaaca aaaagaaaaa atccccaaac ttctcaaagt agactcttta   5400
 aatttacaaa actctagcca gttggataac tctgtatcag atgatagtcc catctttttt   5460
 tcagatccag gctttgaaag ttgttactca cttgaagata gtttatctcc tgaacataat   5520
 tataattttg atattaacac aataggtcag actggatttt gtagctttta ttctggaagt   5580
 cagtttgtcc cagctgatca gaatttgcct cagaagttcc taagtgatgc tgttcaggat   5640
 ctttttccag gacaagctat agaaaaaaat gagtttttaa gtcatgacaa ccagaaatgt   5700
 gatgaagaca agcatcatac cacagactca gcctcatgga ttagatctgg tactttaagt   5760
 cctgaaattt ttgagaagtc aaccatagat agcaatgaga atcgtcgcca caaccagtgg   5820
 aaaaatagct ttcatcctct aacaactcgg tctaactcaa taatggattc tttctgtgtt   5880
 cagcaggcag aagactgtct aagtgaaaaa tctagattga ataggagttc agtaagcaaa   5940
 gaagtgtttc ttagcctccc acagccaaac aattcagact ggattcaagg tcacaccaga   6000
 aaagaaatgg gacagtctct tgactcagcc aatacctctt ttactgcaat actctcctcc   6060
 cctgatggtg aacttgtaga cgtggcctgt gaagatttag aactgtatgt ttcaagaaac   6120
 aatgatatgt tgacaccaac tcctgatagt tcaccaagat ctactagctc tccttcacaa   6180
 tctaaaaatg gcagcttcac ccctcgaact gctaacattc tgaaaccact tatgtccccc   6240
 ccaagtaggg aagaaattat ggcaactttg ttggatcatg acctgtctga gactatttac   6300
 caggaaccat tttgcagtaa tccttctgat gtaccagaaa agcccaggga gattggtgga   6360
 cggctcctca tggtagaaac tcgacttgca aatgatctgg ctgagtttga gggagacttt   6420
 tccttggaag gacttcgtct ttggaaaaca gcattctcag caatgactca gaatccaagg   6480
 ccagggtcac cccttcgcag tggccaagga gttgtcaata aagggtcaag taatagccct   6540
 aagatggttg aagataaaaa aattgtgatt atgccttgca aatgtgcccc aagtcgacaa   6600
 ctggttcaag tgtggcttca agccaaagaa gaatacgaac gttccaagaa actgcctaaa   6660
 accaagccaa ctggagttgt aaaatctgct gagaacttta gctcttcagt taacccagat   6720
 gacaaacctg tagtgcctcc aaaaatggat gtaagtccat gtatactccc cactacagca   6780
 cataccaagg aggatgttga taattctcag attgctttac aagcaccaac cacgggatgt   6840
 agtcaaactg caagtgaaag tcagatgctg ccaccagttg cctctgcaag tgatcccgaa   6900
 aaagatgaag atgatgatga taactattac attagttata gctcccctga ttctccagta   6960
 attccccctt ggcaacaacc aatatcccca gattccaaag cattaaatgg agatgataga   7020
 ccctcatcac cagtagagga gctgccttca ttggcttttg agaacttctt aaagccaata   7080
 aaagatggta tacaaaaaag cccctgcagt gagcctcaag agcctctagt gatatctcca   7140
 attaatacta gggcaagaac tgggaaatgt gaatcacttt gctttcatag tacaccaatc   7200
 atacagagaa aacttctgga aaggcttcct gaagcacctg gccttagccc attatcaaca   7260
 gaaccaaaaa cacagaagtt gagtaataag aaaggaagta atactgacac tcttagaaga   7320
 gtactgttaa cacaagcaaa gaatcaattt gcagcagtaa ataccccaca gaaagaaact   7380
 tctcagattg atggaccatc tttaaacaat acttacggtt tcaaagtcag catacaaaac   7440
 ttacaggagg caaaagcttt acatgagata caaaatctta ccctaatcag tgtggagttg   7500
 catgctcgaa ctagacgaga cttagaaccg gatcctgaat ttgacccaat ctgtgctctg   7560
 ttctactgca tctcatctga cactccactg ccagatacag aaaaaacaga actcacaggt   7620
 gtaatagtga ttgataaaga caagacagtt ttcagtcaag atatcagata tcagactcca   7680
 ttacttatta gatctggaat tacaggactc gaagtcacct atgctgctga tgagaaggca   7740
 ctttttcatg aaattgcaaa tataataaag aggtatgatc ctgatattct gctaggatat   7800
 gagattcaga tgcattcctg gggttacctc ttacaaaggg ctgccgcttt aagtattgac   7860
 ttatgtcgga tgatctctcg ggtgccagat gacaaaattg agaacagatt tgcagctgaa   7920
 agagatgagt atggatcata tacaatgagt gagataaata ttgttggccg aattacacta   7980
 aatctttgga gaatcatgag aaatgaggtg gctctaacta actacacctt tgaaaatgtg   8040
 agctttcatg ttcttcatca gcgttttccc ctctttacct ttcgagtctt gtcagactgg   8100
 tttgataaca agacagatct atacagatgg aaaatggttg atcattatgt tagccgtgtc   8160
 cgtggaaatc tccaaatgtt agaacagctg gacctgattg ggaaaaccag tgagatggct   8220
 agactttttg gcattcagtt tttacatgta ctgacaaggg gttcacagta ccgtgtggaa   8280
 tcaatgatgt tgcgtattgc taaaccaatg aactatattc ctgtgacacc tagtgttcag   8340
 caaagatccc agatgagagc cccacagtgt gttcctctaa ttatggagcc tgaatcccgc   8400
 ttctatagca actctgttct cgttttggat ttccaatcac tttatccttc tattgtgatt   8460
 gcatataact actgcttttc cacctgcctt ggccatgtgg agaacttggg aaagtatgat   8520
 gagttcaaat ttggctgtac ctctctgaga gtacctccag atttacttta ccaagttagg   8580
 catgatatca cagtgtcccc caatggagta gcttttgtca agccttcagt aagaaaaggt   8640
 gtactaccaa gaatgcttga agaaattttg aagactagat ttatggtgaa gcagtcaatg   8700
 aaggcttaca agcaagacag agccctgtca cgaatgcttg atgcgcgtca gttgggactt   8760
 aagctgatag caaatgtcac atttggctat acatctgcta atttttctgg gagaatgcca   8820
 tgcattgagg ttggcgatag tattgttcac aaagccagag agaccttgga acgagctatt   8880
 aaactggtga atgataccaa gaaatggggg gctagggttg tatatggcga tactgacagt   8940
 atgtttgtgc tactgaaagg agccactaag gagcagtctt ttaagattgg tcaggaaatt   9000
 gccgaagctg taactgctac caatcctaaa ccagtgaaat tgaagtttga aaaggtatat   9060
 ttgccctgtg ttttacaaac aaaaaagagg tatgtgggtt acatgtatga aacactggat   9120
 cagaaggacc cagtatttga tgcaaaagga atagaaacag tcagaagaga ttcctgccct   9180
 gctgtttcta agatacttga gcgttctcta aagctgctat ttgaaacgag agatataagt   9240
 ctaattaaac agtatgttca gcgacaatgt atgaagcttc tggaaggaaa ggccagcata   9300
 caagacttta tctttgccaa ggaatacaga ggaagttttt cttataaacc aggagcttgt   9360
 gtgccagccc ttgaacttac aaggaaaatg ctgacttatg accggcgctc tgagcctcag   9420
 gttggggagc gagtgccata cgtcatcatt tatgggaccc ccggagtacc acttatccag   9480
 cttgtaaggc gcccagtgga agtcctgcag gacccaactc tgagactgaa tgctacttac   9540
 tatattacca agcaaatcct tccacccttg gcaagaatct tctcacttat tggtattgat   9600
 gtcttcagct gggtatcatg aattaccaag gggatttatt gcggcactat tcacaatagc   9660
 aaagacttgg aaccaaccca aatgtccatc aatgatagac tggattaaga aaatgtggca   9720
 catatacacc atggaatact atgcagccat aaaaaaggat gagttcatgt cctttgcagg   9780
 gacatggatg aagctggaaa ccatcattct cagcaaacta tcacaaggac agaaaaccaa   9840
 acaccgcctg ttctcactca tagatccata aagctaccag cccctcgcga agtgaacctg   9900
 aagggcggaa aggcactatt tcacaatatt ttactacctt acactgtcct gtgtgtgatg   9960
 acctaactca gcatggcatc tgtagtaaat gtcggagcca acctcagcat gttgcagtca  10020
 tcctcaacca agaaatccgg gagttggaac gtcaacagga gcaacttgta aagatatgca  10080
 agaactgtac aggttgcttt gatcgacaca tcccatgtgt ttctctgaac tgcccagtac  10140
 ttttcaaact ctcccgagta aatagagaat tgtccaaggc accatatctc cggcagttat  10200
 tagaccagtt ttaaattgtc aatatcacag tattacaggt gctatttttt tcagtgctta  10260
 ccactaaact gttgtgcatg gtgcttttta actttcaacg agtcaaggat gttcactgtc  10320
 tgttatctga agactatgaa gacttctatg ctaaccgaat taaaatgtac ttgttgatct  10380
 ctgaatagct cacttcttac aatgtacaaa ttcctcattc tgtcaccttt taaacattgt  10440
 tttataatgc aggtgttgga tttgctccag tatgtgtacc atcttgtaaa ttcatttgag  10500
 tagatcatgt ttacttccca gtggaaggag cactgaaaac ctcttaaaga aaaagcattt  10560
 gtgtgttttc cttgaactgt ctgtatcaag acgtgttact tcgagatatc cattcacttt  10620
 ataattttga ctgcaaaata ttttgtaaat acactttttt acttttcaaa cgagcaaaat  10680
 aatgtgcaat gatttttata caaatgattt tcaagttgtt tggtatattt cctctaggtt  10740
 ttgcttgact caaagtagat cgttattttg atcaaactgt gcaaacagta gtaccacgtg  10800
 tagcattttg aaacattatt tttttttaaa aaatgctgtc ttgctttagc tattaatggg  10860
 gcattgtgag gaactgtgca aagacatttt tgttacaaac ctgtgggcct gttgcaatac  10920
 tttaaaaata aaaaatttta ttccatttgc ttgttttgta tagacatttc tattgcttct  10980
 aaatatactt aaaatatttt ctttccttat gtactgtaca gttaatctta tttgccatca  11040
 tcttgaacac aaaatgtgta tttagaatat ttgtataact gtgtaaaata aaaaaggaat  11100
 tatgtggtca gtgcattgtt ttttaaactg gaaatcattt tgttttaaaa gttaataatg  11160
 gaaaccatat taaaattg                                                11178



      <210> 2242
      <211> 628
      <212> DNA
      <213> Homo sapiens


      <400> 2242
 tgagtgttgg tgcactggac acttttattg ctgcagtata tgagcatgcg gtgatattac     60
 caaacagagc agaaacacct gtttcaaaag aagaagcttt gctcctgatg aacaagaaca    120
 tagatgtttt ggagaaagca gttaagctgg cagcgaagca gggtgcacat atcattgtga    180
 ccccagaaga tggaatctat ggttggatct tcaccaggga gagcatttac ccctatctag    240
 aggatatacc agaccctgga gtgaactgga ttccatgtag agacccctgg agaaatcact    300
 aaaatatagt aagtttgagg aaatgtctat tgaattagat tcggcaacac accagtgcaa    360
 caaagactca gctgcctggc caaggacaac tctatctatg tcgtggctaa tattggggac    420
 aagaagccat gcaatgctag tgactctcag tgtccccctg atggccgtta ccaatacaac    480
 actgatgtgg tgtttgattc tcagggaaaa ctgttggcac gctaccataa gtacaatctt    540
 tttgcacctg aaattcagtt tgatttcccc aaggattcag aacttgtgac ttttgacact    600
 ccctttggga agattggcat tattactt                                       628



      <210> 2243
      <211> 2151
      <212> DNA
      <213> Homo sapiens


      <400> 2243
 atggatacat tcctcgacac atacactctc ccaagactaa accaggaaga agttgaatct     60
 ctgaatcgac caataacagg ctctgaaatt gtggcaataa tcaatagttt accaaccaaa    120
 aagagtccag gaccagatgg attcacagcc gaattctacc agaggtacaa ggaggaactg    180
 gtaccattcc ttctgaaact attccaatca atagaaaaag agggaatcct ccctaactca    240
 ttttatgagg ccagcatcat tctgatacca aagccgggca gagacacaac caaaaaagag    300
 aattttagac caatatcctt gatgaacatt gatgcaaaaa tcctcaataa aatactggca    360
 aaccgaatcc agcagcacat caaaaagctt atccaccatg atcaagtggg cttcatccct    420
 gggatgcaag gctggttcaa tatacgcaaa tcaataaatg taatccagca tataaacaga    480
 gccaaagaca aaaaccacat gattatctca atagatgcag aaaaagcctt tgacaaaatt    540
 caacaaccct tcatgctaaa aactctcaat aaattaggta ttgatgggac gtatttcaaa    600
 ataataagag ctatctatga caaacccaca gccaatatca tactgaatgg gcaaaaactg    660
 gaagcattcc ctttgaaaac cggcacaaga cagggatgcc ctctctcacc gctcctattc    720
 aacatagtgt tggaagttct ggccagggca atcaggcagg agaaggaaat aaagggtatt    780
 caattaggaa aagaggaagt caaattgtcc ctgtttgcag acgacatgat tgtttatcta    840
 gaaaacccca tcgtctcagc ccaaaatctc cttaagctga taagcaactt cagcaaagtc    900
 tcaggataca aaatcaatgt acaaaaatca caagcattct tatacaccaa caacagacaa    960
 acagagagcc aaatcatggg tgaactccca ttcacaattg cttcaaagag aataaaatac   1020
 ctaggaatcc aacttacaag ggatgtgaag gacctcttca aggagaacta caaaccactg   1080
 ctcaaggaaa taaaagagga gacaaacaaa tggaagaaca ttccatgctc atgggtagga   1140
 agaatcaata tcgtgaaaat ggccatactg cccaagctga taggcaactg cagcaaaatc   1200
 tcaggataca aaatcaatgt gcaaaaatca caagcattct tatacaccaa taacagacaa   1260
 acagagagcc aaatcatgag tgaactcgca ttcacaattg cttcaaagaa aatcaaatac   1320
 ctaggaatcc aacttacaag ggatgtgaag gacctcttca aggagaacta caaaccactg   1380
 ctcaatgaaa taaaagagga tacaaacaaa tggaagaaca ttccatgctc atgggtagga   1440
 agaatcaata tcgtgaaaat ggccatactg cccaagagca gagtttgtga tcttcggtat   1500
 ttgcactgga tctacggatc tgtgtcctat ggaaaaggca atgcgtggat cacaagaaag   1560
 agaagcacca cccaaaagtg gacaggtgca gcactacagc ccctttccag gacatccctg   1620
 aaagacaccg gagaagggga atcttcccag tgggcagaac ttcgagcagt gtacctgttg   1680
 gttcactttg catggaagga gaaatggcca catgtgtggt tatatactga ttcatgggct   1740
 gtatccagtg gttcggctgg atggtcagga acttggaaga agcatgattg gaaaattggt   1800
 gacaaagaaa tttggagaag agccagctac ctggtggcag attatattgg acctcttcca   1860
 tcatggaaag ggcagagatt tgtcctcact ggaatagaca cttactctgg atatgggttt   1920
 gcctatcctg catgcaatgc ttctgccaag actaccatcc gtggattcat ggaatgcctt   1980
 atccaccatc atggtattcc acacagcatt gcctctgacc aaggcactca cttcatggct   2040
 aaagaagtgc agcagtgggc tcattctcat ggaattcacc ggtcttatca tgttctccat   2100
 cacccagaag cagctggatt gatagaacga tggaatggcc ttttgaagtg a            2151



      <210> 2244
      <211> 4966
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> misc_feature
      <222> (1)...(4966)
      <223> n = a,t,c or g


      <400> 2244
 ctatggggga tcctctagag tcgacctgca ggcatgcaag cgatctaaac actccagttg     60
 aaccacgaga catgtccagg ttaagcacca ttttatcgcc cttatacaaa tactgtcgct    120
 ccaggagcca aactgatgtc gtgagcttaa actagttctg gatgcagatg acgttttagc    180
 cacagaagtt aaaagagtga taacttcttc agcttcaaat atcaccccag cttttttctg    240
 ctcatgaagg ttagatgcct gctgcataag taattcctct ttatctgtaa aggctttttg    300
 aagtgcatca cctgaccggg cagatagttc accggggtga gaaaaaagag caacaactga    360
 tttaggcaat ttggcggtgt tgatacagcg ggtaataatc ttacgtgaaa tattttccgc    420
 atcagccagc gcagaaatat ttccagcaaa ttcattctgc aatcggcttg cataacgctg    480
 accacgttca taagcacttg ttgggcgata atcgttaccc aatctggata atgcagccat    540
 ctgctcatca tccagctcgc caaccagaac acgataatca ctttcggtaa gtgcagcagc    600
 tttacgacgg cgactcccat cggcaatttc tatgacacca gatactcttc gaccgaacgc    660
 cggtgtctgt tgaccagtca gtagaaaaga agggatgaga tcatccagtg cgtcctcagt    720
 aagcagctcc tggtcacgtt cattacctga ccatacccga gaggtcttct caacactatc    780
 accccggagc acttcaagag tatacttcac atcccgacca catacaggca aagtaatggc    840
 attaccgcga gccattactc cggaatagtc agtgtagaat aaacggattt ttccgtcaga    900
 tgtaaaggtt gcagaaccgg accattcttg cgtctgatct ttcaggatcg gatcgttggc    960
 gtcgaactta tcgctgtctt taaagacacg gcccgcgttt ttccagctgt cgattgagtt   1020
 gtcgccgacc ttttgataaa acatgtagat tgatgtgtca tcagcgtctt tcgggcttcc   1080
 cgcaagagca aacacaacgt gatagccgtt gtattcagct actgttccgt cagcgttttg   1140
 cagcggccag ctgtcccaca catcaagtcc ttttgcagac tcaatatttt taatcgttga   1200
 ttgatcgaat tgaggcactt ggtatttttc gttttgctgc tgtttaggga tcattccaca   1260
 gttagcgacg acatgttcaa tccttgacct tgacggcaaa gaatatactc gtagactcac   1320
 gcgaatagtc gcatcaccaa tataaagtgg atccgtgatc ccagtccgat aatcagaccg   1380
 aaaacacaag tggtatcctg gtcccagact aataatcaga ccgacgatac gagtaggacc   1440
 gctgatccca gacgacgata cgagaggccc gtagtcacag actaataata gaccgccgat   1500
 acgagatgga ccatggtccc cgcctaataa actggacgac gatacgatat ggaccgtggt   1560
 cccagtcttt atggcagcaa ccccgatcac cggtgtaaat acgtcttcag cacgtcgcaa   1620
 tcgcgtacca aacacatcac gcatatgatt aatttgttca attgtataac caacacgttg   1680
 ctcaacccgt cctcgaattt ccatatccgg gtgcggtagn cgccctgctt tctcggcatc   1740
 tctgatagcc tgagaagaaa ccccaactaa atccgctgct tcacctattc tccagcgccg   1800
 ggttattttc ctcgcttccg ggctgtcatc attaaactgt gcaatggcga tagccttcgt   1860
 catttcatga ccagcgttta tgcactggtt aagtgtttcc atgagtttca ttctgaacat   1920
 cctgaccggg cagatagctt caccggggtg agaaaaaaga gcaacaactg atttaggcaa   1980
 tttggcggtg ttgatacagc gggtaataat cttacgtgaa atattttccg catcagccag   2040
 cgcagaaata tttccagcaa attcattctg caatcggctt gcataacgct gaccacgttc   2100
 ataagcactt gttgggcgat aatcgttacc caatctgaat aatgcagcca tctgctcatc   2160
 atccagctcg ccaaccagaa cacgataatc actttcggta agtgcagcag ctttacgacg   2220
 gcgactccca tcggcaattt ctatgacacc agatactctt cgaccgaacg ccggtgtctg   2280
 ttgaccagtc agtagaaaag aagggatgag atcatccagt gcgtcctcag taagcagctc   2340
 ctggtcacgt tcattacctg accatacccg agaggtcttc tcaacactat caccccggag   2400
 cacttcaaga gtaaacttca catcccgacc acatacaggc aaagtaatgg cattaccgcg   2460
 agccattact cctacgcgcg caattaacga atccaccatc ggggcagctg gtgtcgataa   2520
 cgaagtatct ttaccaactt catccgtttc acgtacaaca ttttttagaa ccatgcttcc   2580
 ccaggcatcc cgaatttgct cctccatcca cggggactga gagccattac tattgctgta   2640
 tttggtaagc aaaatacgta catcaggctc gaacccttta agatcaacgt tcttgagcag   2700
 atcacgaagc atatcgaaaa acttgagaac attgccttct aataggtttg gaccctggag   2760
 ttgtaattct gaacaagtct gtgggatatt cactgttggc tccttcagct gcactctcca   2820
 gacttctcca ctctgctccg agatccaaga ggttgcctta tgtggtctat accaataggc   2880
 tcccttgcca tctggttctg ccttgagtga caggaccttg actgatccag tgccccagga   2940
 cttccacagc tttgtcacct cattgactct cactttatca tggggggatc ctctagagtc   3000
 gacctgcagg cattcattgt ngcagctatg atcggtcaca gcaaaaggat acaaagcaaa   3060
 atcagcaaag ggtaaaggag tattgggtga agtccagggg aaatgaggca caagcttcca   3120
 agaggcctct cccttataag atgaatagga atcttcagac cagtaaggta ggaagagtat   3180
 tcggacatta atcgtgccga tacccaggtt aggcgcgctg tcaataacta tgacatcata   3240
 gtcatgagca acagtttcaa tggccagtcg gagcatcagg tgtggatcgg tgggcagttt   3300
 accttcatca aatttgccca ttaactcagt ttcaatacgg tgcagagcca gacaggaagg   3360
 aataatgtca agccccggcc agcaagtggg ctttattgca taagtgacat cgtccttttc   3420
 cccaagatag aaaggcagga gagtgtcttc tgcatgaata tgaagatctg gtacccatcc   3480
 gtgatacatt gaggctgttc cctgggggtc gttaccttcc acgagcaaaa cacgtagccc   3540
 cttcagagcc agatcctgag caagatgaac agaaactgag gttttgtaaa cgccaccttt   3600
 atgggcagca accccgatca ccggtggaaa tacgtcttca gcacgtcgca atcgcgtacc   3660
 aaacacatca cgcatatgat taatttgttc aattgtataa ccaacacgtt gctcaacccg   3720
 tcctcgaatt tccatatccg ggtgcggtag tcgccctgct ttctcggcat ctctgatagc   3780
 ctgagaagaa accccaacta aatccgctgc ttcacctatt ctccagcgcc gggttatttt   3840
 cctcgcttcc gggctgtcat cattaaactg tgcaatggcg atagccttcg tcatttcatg   3900
 accagcgttt atgcactgca ggaagcggcg gcggaagtca ggcatacgct ggtaactttg   3960
 aggcagctgg taacgctcta tgatccagtc gattttcaga gagacgatgc ctgagccatc   4020
 cgggcttacg atactgacac agggattcgt ataaacgcat ggcatacgga ttggtgattt   4080
 cttttgtttc actaagccga aactgcgtaa accggttctg taacccgata aagaagggaa   4140
 tgagatatgg gttgatatgt acactgtaaa gccctctgga tggactgtgc gcacgtttga   4200
 taaaccaagg aaaagattca tagccttttt catcgccggc atcctcttca gggcgataaa   4260
 aaaccacttc cttccccgcg aaactcttca atgcctgccg tatatcctta ctggcttccg   4320
 cagaggtcaa tccgaatatt tcagcatatt tagcaacatg gatctcgcag ataccgtcat   4380
 gttcctgtag ggtgccatca gattttctga tctggtcaac gaacagatac agcatacgtt   4440
 tttgatcccg ggagagacta tatgccgcct cagtgaggtc gtttgactgg acgattcgcg   4500
 ggctattttt acgtttcttg tgattgataa ccgctgtttc cgccatgaca gatccatgtg   4560
 aagtgtgaca agtttttaga ttgtcacaca gagcagacag gttgagcttc acaccagcct   4620
 caaggggtgg agtgtagctg accccagtca accagtggtt gactttggta gaaatgaaag   4680
 caatgggttt caattgaaat ttagctgcaa ggccaaaacg agtgcagctg gtacttgatg   4740
 tccaagccag gtttattaaa gcatcaagtt cttcacaaac tttttgataa actgatcctc   4800
 caaattctgc cccatcattg acattagtgt gcagctggaa gtccccagtc ctgtagccca   4860
 ctgcaaagtt attctttgtc tgctttgact tggtgctgtt aaagctcatc tggtacccag   4920
 caagctgagc catgaattgc aagtccagca aaatcaaagt taacat                  4966



      <210> 2245
      <211> 3226
      <212> DNA
      <213> Homo sapiens


      <400> 2245
 tttttttttt ttttatttaa ttttttaata aaccataaaa tttaaatatt caaatgaaaa     60
 gaaacaaaaa tagattattt aagccagcat gaatttctgg ttttactctt cctctagggc    120
 attgtaggct tgacttacct ggggattaga gtagtaaagc tatgatgctg ggtacaataa    180
 tgaatgaggg aggtaaaaat ggggcaatgt cttgcataaa atttactttc aaatctagga    240
 tcagaagttc actcaagcct actgcaaagg cctgacactg gttttttgtc tgtataaaac    300
 tactctgggc tttttaccac actttcttca tcacagctta ggtgttccct ggcattctga    360
 tccttttgct cactaaagct cacttcaatc tgtcaaaaca tcaaggggga aaatccccaa    420
 aatgaaccga cgaataaaca ctcttaatgt gaacaatcat attcagacca gcctcttgtg    480
 caaaaataca agtcagtgga ttttttatcc ttacataact caaatattgc tatttttttc    540
 ctgcctttac taaaatggca ctttcgttta catcaaccaa ttattttcta cttgcttcta    600
 agtttctgag attgtatgct gtactggcta ttctttttga ttaagcttta caatttccat    660
 tccagaatat ctggtctttg accaacttta tctaattttg tgaagaaatg tgctattaat    720
 cagtgaaaat cgcaaaagga aaaagaaaag gaagcaatga acaatagtag aatctcactt    780
 cagcatttgt ataatttttt ataagaaaaa cattcatttt tattatggga tctaaaacca    840
 tgatcgtgtc tgatactgta agccttttag cgtactcaaa tgggtcaaca ttcaatatgg    900
 acagccagct agctcacaag aaatgaaatg taatgcacaa atatgtttga ctggtaaaat    960
 cccagaggct tggtaataaa gtgcagcaaa ctttccttat attgaataag aactccagta   1020
 acctctggat atttttggta aaaattaaag aaaaggtact gcagtcaaga gacaggtaat   1080
 ctttaaactt caaaagactg gctgccaggg accacagtga aaaattagac ctggagccaa   1140
 tgaaaaacac tagcttggaa ggaatgggtt tttccaaaaa tgcaaaatta gcatttacag   1200
 atgcttagga tactatgatt tgacaggctt acagtgataa aacaacaaag atgaacagtt   1260
 acaatattta tacgtgtagt gtgtaaagaa cacaggtttt ttaattggca gcaagaaatt   1320
 ctatgacagc ttctgagaca agtaatccta tgccctatat ccaccccatg ccaatgacga   1380
 ccagtcaaaa tggtaacaca gagtaaaaag tgatctactg tatgtgagtc agaaagtact   1440
 tgaaaagtga caaaactgta tgttattaaa tgccaaaaca tatttagagg ctttatttaa   1500
 aaatctctca ctgttcatta tcaaagttac aagattgcat accaatagac agactgtaaa   1560
 cataggaaat tttcgttaag gaaagatggg tttactgtaa ttcaatcttt tacaaaaaat   1620
 tacttgcaag ttattgataa cagaatttct cttttacttt cttaattctc ttgaaaatta   1680
 aaccaatgtt tccactttca tgagctaaag ttcaaccatg gtcaccttag gaaatacccc   1740
 tgtttatttg ttaatcagaa atacaaatcg agtggcacat acttccattt tcttcttagg   1800
 ccaaaggttt cagcttcatt atattttaca gaagaccttc agtggtccgg taagtctttc   1860
 atgtcacagc tgaggtttaa tgatggcagt ggaggaaagc agaggtgatg caaagtaaga   1920
 ccagcccagt tgccttatct gacatggaat ctttttcctg tctggcttgc agcagcgaag   1980
 tgtttctggt caggttgcct ccaccaaacc tgattgaagc aaaagggtga catgctctga   2040
 taaatcccat ttaaggatga ttctgttcag gcaaatagtt gatccttcaa tctgttggct   2100
 gtgggatgat actaatatga agaaaattat ccgggtagct cagatgttca ctcagccact   2160
 gcagaggtgt ttccaacatt ggctcaattc catgaatcat cacttgattc tttttttccc   2220
 catcttcagg atcaatagca gaaggacaaa cttctttgag gagatctcct agtgtgtgca   2280
 actgtccatc tgcagccaca ggacgaaaca gcttctgaat gaaaggtctt tcagtcgttg   2340
 tctgatatat tctaaagggg atataacgaa atccattttc ttctgcagga tattccatga   2400
 gtttccgatt gatggcccaa aactggtcaa atctgtcatt ttgcaatccc atccagagtt   2460
 gcttgtgatc ttttttctgc atttcattga ttacttgact tttatgtttt aaagcatcag   2520
 cttctttcat acatgacata aaatgagctt caattgcatc cttagatgga cagtgcagaa   2580
 ggtctttttc tggaaaactc ttaaaatgta ctgtgatgtt ccaaggaaga gctgaacttg   2640
 atgcaagaag atcaaatagc aaaccaattg gataatgcca tttcagtggt gtgccttcat   2700
 attcaaacca tatctcacta atgtcttctt gtctcataac cttctgaaag tgctttttca   2760
 ctttgtcagt taccaacgtc aaataactta ctcttggcaa aagcaaatag tatggttctg   2820
 cttccctttc agttatctca tcctgatata gcgtgaaaca agttggaatt cgtccaaacc   2880
 acacatctcg aagcacatct ttgtcatctg tcattcttcc aggagttaaa gcagtacata   2940
 caggctaaat tcttatttca accaaagcca aacctactcc aagctatggc tcctccttcc   3000
 ggctccccgc actggtgggg acgcccagat tccgcgctcc ggtggggcgg cggggcaagc   3060
 tgcccgcctg acacactgtc ctgcggggac gcggtagcag gactccagga agcccgcgca   3120
 gccgcaaaaa gcaccggcgc ggaggtcgga gctgaaccct gctgcacttc cgccctctgg   3180
 tatccagcga atacaaccgg caacgctgcg gagccctggc acgaaa                  3226



      <210> 2246
      <211> 1447
      <212> DNA
      <213> Homo sapiens


      <400> 2246
 atggacagaa tcctgggact agtgccagtg actctgtgga tacgccgagc gatctgggcg     60
 tgcactgctg tggtggcctt tatggtcagg aggcgacatg cagtgagaag aagggaagaa    120
 ctggcccaaa gggattcagc ccagggtgag gtccacggaa aggccagggc caagatgcag    180
 ccagcacccc aggccggtgg tggcctcaca tcacccatgc cagaggtcag tcctcgattg    240
 ctccaaaccc tctgctcaag ggttcagaag gaaatgagca ggtcttccca tcagggccca    300
 gatgagcttc tgaaaacaag tgtgacaaaa caacctcctg aacatcctgg aatgaccgat    360
 gcaaagtaca ccccacacgg ttcacagcac gaagatcatc aggggcaaac cgtggacgat    420
 ctgaatgaca gcacagaccg tcagcaacct gcagagctgc ctggccaaga aattacgaga    480
 cggaagcaac gcttgcaggc gaaggaggag aagaaggaaa ggccagagca ggcaggggca    540
 ggagtggaac gggccgcgaa tgtcggagtg aagtgcagac cttcctggcc cacacccctc    600
 cgagcatgtg ctcgagggca gtgtaaagaa ctcacagcgg aagtccaaag tcttcctgca    660
 ggcctccctg cggggcacga gggcacagct ggagagggag cttccaaaac tgcagctgag    720
 ggttcccgct gcctacactg caccgagaac tcccgtgatg gggtctcacg ggagtccacg    780
 gaggagaacg cctactgcct ggacctcgac cagagacttc gaaaggtgca cgaaaacact    840
 tgcaaccact acaagaagat gacccaagac ctggcccagg aatcgaaaaa agacacttcc    900
 aattttcaga gggagatctt cttccgtgag aaaatggccc aggaaggccg gatggctgct    960
 gtatccactg agacagcgct ccagccgctc cgggaagaaa atgaccacag caggcagaag   1020
 ccagctgatt ttgaggccaa gttccagctt ctccggggtg gtgctttggc tcctggggtt   1080
 ctgcccgcag cccacagggg cccggaagtg tcagggggac catgggacga cagggccccc   1140
 agaagggagg caggtcacaa tcaatcagaa gatgttggag aatcctattc acaggaatac   1200
 ttggtagatt cgcagtttga agagtcccca ccatgggcac atggattgca ggaggctaga   1260
 ggaccaggaa aggcaattgc gggtgtccct gtgagaagcg aagagggggt gactgcagca   1320
 gaggcagcgg attggcagga ggttcccctg aaggatgcta aggaatacgc tgaatccata   1380
 ggtgccatcg tggttgagac aagtgcaaaa aatgctatta atatcgaaga gctctttcaa   1440
 ggaatca                                                             1447



      <210> 2247
      <211> 831
      <212> DNA
      <213> Homo sapiens


      <400> 2247
 atgccccggg ctgccctgca ggacgccccc cgcgcagtgc atggcgacaa atacgcaggt     60
 caggaagagg cgcagaaaaa taactggtct gtttccattg ctgttgccga tgacggcggt    120
 catctgctgg cgttaagtcg catggacgat tgcgcgccga ttgcggctta tatctcccag    180
 gagaaagcgc gtaccgccgc gctggggcgt cgtgaaacta agggctatga taatgacatg    240
 atacaatcga tgctcgatcg cattgaacta accgtgtttg tcgataacgc cccggcaatt    300
 aaggtctata aaaaatacgg ctttgaaatt gaagggactg gtaagaagta cgcattgcgt    360
 aatggtgaat atgtcgatgc atattatatg gcgcgggtga acaaaatcag actccacgga    420
 catgtaattt tgataacgaa caaacccacg ctcacgggca gtctggaaaa agtacgcgag    480
 caggtacagg cggcgcacgc gctggggctg acggcggtga tcagttcttc cattgaatcg    540
 agcttaggct taacgcaact ggcgcggatt gccgcctggt taacgccgga caccattcca    600
 gggctggaca cgctggatct gatgcaggcg cagcaggcca tgtgtctcct gatctgtgcc    660
 gagatgtacc aagtgtccag actgcagcac atctgtgagc tgttcatcat tacccagctg    720
 cagagcatgc caagcaggga actggcatcc atgaaccttg atatagttga cctgcttaaa    780
 aaggccaagg tcttcaagac aggggacctt atcatgggca tgcatgactg a             831



      <210> 2248
      <211> 855
      <212> DNA
      <213> Homo sapiens


      <400> 2248
 atgaccaccg ggccacgatc gtcaagccga cccacgcgac accataacaa taacgcgact     60
 atcaccttca ccttccacaa tacgaacgaa gtcgacaagg accgtttgat gagaaaggag    120
 agagaagttc tgatggctca taacctcaca ccagggcagc ttcagctgtt tcattccctc    180
 atgttagctc ccagatccct ggcgatgctg gaatctgaga gcctggaagg ctcacacagt    240
 cgacaaaaga aaacgttttt cttgggagat gggcagaagc tgaaggactg gcatgacaag    300
 gaggccatcc ggagggacgc tcagcgcgta gcaggagctg aggtttatgt ttgccttttg    360
 ttccttcaaa ctgaattttg gcaacagcat gtcaagaaca agattgaggg gctgtttgtt    420
 tgtgccagct gcctttgctt ccaccagaag ctgcactggg gactgcgtag ccagagaacg    480
 gaagcgaggc agtttggccc agactcactg gacctgcaaa tgggagtcag ccagctggct    540
 ctgagtgggc ctgccctctg cacctcctgc caagtgagcg tgaacagtgg ctggctggtg    600
 ggctggccca ctttccctac tccctgggag ccctgctggg ctgcttggca actgagcgtg    660
 gaggcccctc cagagcacag ggctgatggc acaacagaga cccaactgct aaagtgcctg    720
 ggatctgcag tttccggtgc aaaccccagg ttaggtggtc agtttctcct atgcaaagat    780
 tatccatgga tatccaggat atccagagat atcctgacct gctttctcca ttccatagtt    840
 ttagcttcac aatga                                                     855



      <210> 2249
      <211> 1634
      <212> DNA
      <213> Homo sapiens


      <400> 2249
 atggagattc ctgctgtgat cttaacagtt gctcccatcc tccacttaac tagctgtggt     60
 ttccctgtga ctggagatgg tctaaaacaa gcagagggca aatgtgctcc tgaagaatgg    120
 aatcccacaa agttcataaa actaacagac aatcaagcat gctttgcttg tggcttatgg    180
 cctttatccg agattcaaag gagaacctca aggactgtta ctataatatc caggatatca    240
 gccctaagag aaaagggaaa tggaagaaag cctaccagca tttcaggatc agtaaatgaa    300
 atgagacagg ttctggtgaa agaccaggtg tcaatgccaa gagttctccc tacaattatt    360
 tttgttccag acgaggcagg cttcagtgca ggagccgtgt ggccatgtgc agctcctctg    420
 tggggcagca gctggactcc actaaaagtg gaaaactgct cgttctacat tagactctct    480
 ttcgcaattt cggtaggtgg tgatgagctg aagatagcaa aattggtttc agcttttcct    540
 gaaagagctt atgatttagt tggtcaccaa catcaaagac caaaggtaga taaaaccaca    600
 aagatgggga gaaaccagag cagaaaggct gaaaattcca aaaaccagaa catgtcttct    660
 cctccaaagg aacacaactc ctctccagca agggaacaaa actggatgga gaatgagttt    720
 gatgagttga gagaagtagg cttcagaagg tcggtaataa caaacttctc cgagctaaag    780
 gagcatgttc taacccatca caaggaagct aaaaaccttg aaaaaaggtt agatgaatgg    840
 ctaactagaa taaacagtgt agagaagagc ttaaatgatc tgatggagct gaaaaccaca    900
 ttacgagaac ttcgtgaagc atacataagc ttcaatagcc aattcgacca agcggaagaa    960
 agggtatcag tgatcgaaga tcaaattagt gaaataaagc aggaagtgaa gtttagagaa   1020
 aaaagagtaa aaagaaatga acaaagcctc caagaaatat gggactatgt gaaaagacca   1080
 aaatctacgt ctgattggta tacctgaaag tgacgaggag aatggaacca agttggaaaa   1140
 cactctgcag gatattatcc aggagaactt ccccaacata gcaaggcagg ccaacattca   1200
 aattcgggga aattacagag aacgcccaca aaggttgcct cctcgagaac agcaactcca   1260
 agacacataa ttagtgtggg ttcaccaaag ttgaatatga agggaaaaaa tattaagggc   1320
 agcccagaga gaaaggtcgg ggttacccac aaaggggaag cccttcagac taacagcagc   1380
 ggatctctcg gcagaaactt ctacaagcca gaagacagag tgggggccaa tattcaacat   1440
 tcttaaagaa aagaattttt caacccagaa atttcatatc cagccaaacc taagcttcat   1500
 aagtgaagga gaaataaaat actttacaga ccaagccaaa tgcttgagag atttttgtca   1560
 ccaccagggc cttctcttgc ctgccctaaa agagcaccag gcctgcccta aaagagctgc   1620
 tgaagggaag cact                                                     1634



      <210> 2250
      <211> 509
      <212> DNA
      <213> Homo sapiens


      <400> 2250
 gaatgttcca gataatccct ttcccagtcc tgcctgacat ctgggtaggg ggtttgtccc     60
 tggaattctg ggacactggc tggggtttga ggagagaagc cagtacctac ctggctgcag    120
 gatgaagctg gccagtggct tcttggtttt gtggctcagc cttgggggtg gcctggctca    180
 gagcgacacg agccctgaca cggaggagtc ctattcagac tggggccttc ggcacctccg    240
 gggaagcttt gaatccgtca atagctactt cgattctttt ctggagctgc tgggagggaa    300
 gaatggagtc tgtcagtaca ggtgccgata tggaaaggca ccaatgccca gacctggcta    360
 caagccccaa gagcccaatg gctgcggctc ctatttcctg ggtctcaagg taccagaaag    420
 tatggacttt ggggcattcc aagcaatgac aaagttgctg caaccaactg gatgtctgtt    480
 atgacacttt gcggtgccaa caaatatgg                                      509



      <210> 2251
      <211> 1480
      <212> DNA
      <213> Homo sapiens


      <400> 2251
 accgctttgg agttcccggg acgacgactt cgtggcccgc ggtacctccc gcactctgac     60
 ctgcggcccg taggtccgag ccggggacgg cggcgtcggt gggtcatgct ccggcactcc    120
 ccctcgctgt gggagctggt ggaggagcac gttccgctcc gggagcgacg cgaagtgaag    180
 aggattctgg gggaggcggc ggtggacctg agcctggagc tgcgggcgga ggtggcgatg    240
 ttacgggcac tgctccaaga ggctcgatcc tctcaagccc ccagctcccg ccccatctct    300
 gacccctctt ctcttctggc accaccgcct ctcctaaagg acctcttgcg ccaggagctc    360
 cggcagttgc tccagggtct ccgccacaaa gccatctgtg agggcaggga ccaggcccaa    420
 gcttgggtcc agtatagccc cagggtcctg cactttgcct tggaggagcc caggtgtgat    480
 ttgccagaac aggagatatt ccagatgaga ggtggtgggc ccagttgcct agaagtgata    540
 tttgggtcct gaaggcctgg ggtgagcaac atgcggtgag tgatagtgac ttcattgcca    600
 gcagcggtca cagagatctc agcatcatca aggaccaact gaacgtgtcc aacattgacc    660
 aggtggccag acacctgagg ggccttctgg aggaggagtg tcacaccttg gagagggaga    720
 tcctcatcct gcagcgctgc ctggaagagg agtatttgag gccttgccac ccctctgagg    780
 cagccctgga gcccaccctg gcagagctaa aggaacagaa gaaggccatg gagcaggagc    840
 tgcaggcatc tgtggggcct tcttgtgtct ctcccaacca caggcagcgg cccttggggt    900
 cctccacaca gggcctcaga cccccgcttc ccctctgcgg ggttgcacct ctccagtgct    960
 gcctgcctgc acctcctctg gagccctacc ttcgacctcg aggccagtcg gctacccacc   1020
 gctggggacg gcagcttcag tgcagcccca gggaagggcc agcttccaca cccatgtcca   1080
 gtgcagcacc ccaagtccca gcctgaaggg ctggtcaccg agtaggctct ggcttctgcc   1140
 acagcgcacc tgtctgccgc tgccgcctca gctgctttgg cccagccagc ttcagatctg   1200
 gtcttggcga gctctcgcca ggaccccaag gctgttggtc tgtctggccc ttgccccacc   1260
 cccttgccag atccctggtg tctggagctg agtggccggg catcggtccc aagcatcaaa   1320
 gcctttggcc tttctcctcc caggcctcca caaaggcctg gcagacagag gtctcattcc   1380
 agcctgactc ttgtcccctg ggggacccag acaaagcaca gcagccgctc agagacagga   1440
 atagaaattt cattaaaatc tatggacttt aaaaaaaaaa                         1480



      <210> 2252
      <211> 748
      <212> DNA
      <213> Homo sapiens


      <400> 2252
 atataaaaat accatcacag actactacga acacctctat gcacacaaac tagaaaatct     60
 agaagaaatg aataaaagaa gagctagtac catctgtact gaaactattc caaaaaaact    120
 gaggaggagg gactcctcct taactcattc tatgagagcc aggagactga gtgtggacgt    180
 gaaacctcag gacaggtcac ggggtccatc tgaatgcact atattcaggg caggtgtccc    240
 agagggaaca agaggggcct tgtggctgcc tcacttccaa acagaaagtg acccaggctc    300
 caagcctgca atcacgcttc ttgttattca tccagatgaa ttgcaaattt atgtccgcac    360
 aaaaacctgc acagatgttc atagcagctt tattcataat tgccaaaact tagaagcaac    420
 caagatatcc ttcatgtttg ataacaagca cctgacgcgt ggcgtgatgc cagcctcccc    480
 agggcgcttt ggtctggaaa cagctgtgag taatctggag cacccagagc agaaagcttt    540
 atcagtcagc ctgccccaaa agctgctgcg aaaactatct gctggtgcag tcatgcctcc    600
 aactgcccta tttttagtga aacgcacttt ccagggctgt gcttctgatg aaggagcaag    660
 ccgacttggt cttaagacat acatagtcag tgacaaccaa gccacttcca ctcgtctgcc    720
 tgatttaggg ttttctgcag gtttatga                                       748



      <210> 2253
      <211> 2352
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> misc_feature
      <222> (1)...(2352)
      <223> n = a,t,c or g


      <400> 2253
 aaagggtgct taacttctaa ttatttgatc actgaggaaa atccagaaag ctacacaaca     60
 ctgaaggggt gaaataaaag tccagcgatc cagcgaaaga aaagagaagt gacagaaaca    120
 actttacctg gactgaagat aaaagcacag acaagagaac aatgccctgg acatggctcc    180
 agagatccac atgacaggcc caatgtgcct cattgagaac actaatgggg aactggtggc    240
 gaatccagaa gctctgaaaa tcctgtctgc cattacacag cctgtggtgg tggtggcaat    300
 tgtgggcctc taccgcacag gaaaatccta cctgatgaac aagctagctg ggaagaataa    360
 gggcttctct ctgggctcca cagtgaaatc tcacaccaaa ggaatctgga tgtggtgtgt    420
 gcctcacccc aaaaagccag aacacacctt agtcctgctt gacactgagg gcctgggaga    480
 tgtaaagaag ggtgacaacc agaatgactc ctggatcttc accctggccg tcctcctgag    540
 cagcactctc gtgtacaata gcatgggaac catcaaccag caggctatgg accaactgta    600
 ctatgtgaca gagctgacac atcgaatccg atcaaaatcc tcacctgatg agaatgagaa    660
 tgaggattca gctgactttg tgagcttctt cccagatttt gtgtggacac tgagagattt    720
 ctccctggac ttggaagcag atggacaacc cctcacacca gatgagtacc tggagtattc    780
 cctgaagcta acgcaaggta ccagtcaaaa agataaaaat tttaatctgc cccgactctg    840
 tatccggaag ttcttcccaa agaaaaaatg ttttgtcttc gatctgccca ttcaccgcag    900
 gaagcttgcc cagcttgaga aactacaaga tgaagagctg gaccctgaat ttgtgcaaca    960
 agtagcagac ttctgttcct acatctttag caattccaaa actaaaactc tttcaggagg   1020
 catcaaggtc aatgggcctc gtctagagag cctagtgctg acctatatca atgctatcag   1080
 cagaggggat ctgccctgca tggagaacgc agtcctggcc ttggcccaga tagagaactc   1140
 agccgcagtg caaaaggcta ttgcccacta tgaccagcag atgggccaga aggtgcagct   1200
 gcccgcagaa accctccagg agctgctgga cctgcacagg gttagtgaga gggaggccac   1260
 tgaagtctat atgaagaact ctttcaagga tgtggaccat ctgtttcaaa agaaattagc   1320
 ggcccagcta gacaaaaagc gggatgactt ttgtaaacag aatcaagaag catcatcaga   1380
 tcgttgctca gctttacttc aggtcatttt cagtcctcta gaagaagaag tgaaggcggg   1440
 aatttattcg aaaccagggg gctattgtct ctttattcag aagctacaag acctggagaa   1500
 aaagtactat gaggaaccaa ggaaggggat acaggctgaa gagattctgc agacatactt   1560
 gaaatccaag gagtctgtga ccgatgcaat tctacagaca gaccagattc tcacagaaaa   1620
 ggaaaaggag attgaagtgg aatgtgtaaa agctgaatct gcacaggctt cagcaaaaat   1680
 ggtggaggaa atgcaaataa agtatcagca gatgatggaa gagaaagaga agagttatca   1740
 agaacatgtg aaacaattga ctgagaagat ggagagggag agggcccagt tgctggaaga   1800
 gcaagagaag accctcacta gtaaacttca ggaacaggcc cgagtactaa aggagagatg   1860
 ccaaggtgaa agtacccaac ttcaaaatga gatacaaaag ctacagaaga ccctgaaaaa   1920
 aaaaaccaag agatatatgt cgcataagct aaagatctaa acaacagagc ttttctgtca   1980
 tcctaaccca aggcataact gaaacaattt tagaatttgg aacaagtgtc actatatttg   2040
 ataataatta gatcttgcat cataacacta aaagtttaca agaacatgca gttcaatgat   2100
 caaaatcatg ttttttcctt aaaaagattg taaattgtgc aacaaagatg catttacctc   2160
 tgtaccaaca gaggagggat catgagttgc cgccactcag aagtttattc ttccagacga   2220
 ccagtggata ctaaggaaag tcttaggtaa aaatcttggg acatatttgg gcactggttt   2280
 ggccaagtgt acaatgggtc ccaatatcaa aaacaaccat cctagcttcc tagggaagac   2340
 agngtacagt tc                                                       2352



      <210> 2254
      <211> 1028
      <212> DNA
      <213> Homo sapiens


      <400> 2254
 ggtttttagc ttccttgcaa tgggttcaaa catcctcctt tagctcagag aagtttgtta     60
 ttaccgacct tctgaagcct acttctgtca acttgtcaaa gtcattctcc gtccagcttt    120
 gttccattgc tgggggttcc ttaaggccta ccccggaaat tcaagaagtg aaaactcctg    180
 aagaactaga gacctttatg cttaaacatg gagaaaatat tattgatact ttaggagctg    240
 aagtagatag acttgagaag gaactgaaat ctgggagctt agtgccttgc atcccagctg    300
 ctccagctgt gactaaaagg ggccaaggta cagctccagc tattgcttca gtaggtggaa    360
 gccccaagcc ttggcagctt ccacgtggtg ttgggcctgt gggtgcacag aagtcaagaa    420
 ctgaggtttg gaaatctctg cctagatttc agaggatgta tgggaaacac ctggatgccc    480
 agaatgatag atccactgac agcttgcaca gtgcacctgg aaaagccaca gacactcaat    540
 gccagcccct gaaagcagcc aaaagtgggc tatatcctgc agagctaaag aggtggagct    600
 gcccatggct gtgggagccc accttttgca tcagcgtgac ctggagtgat ctagaacaac    660
 ttcgaaaaat cagacgacga agtccccatg aagatactga gtcttttact gtatacttga    720
 gatcagatgt ggaagcaaaa tctttggaag tttggggaag ccctgaagct cttgccagag    780
 agaaaaaatt gcgtaaggaa gcagaaatag aatacagaga aaaagggtct attaactcag    840
 ctacattaat taattcagca gatatttatc cgatacccgc tatgaacaag aagctgtgct    900
 tggtgtttga aatgtatatg caaaattatc cctactatgg caaactcctg cagcccaaat    960
 acctgcagcc tctgcttgct gtacagttca ccagccttac catggacact gaaattcgcc   1020
 tagtgtaa                                                            1028



      <210> 2255
      <211> 817
      <212> DNA
      <213> Homo sapiens


      <400> 2255
 gccggagccc gcaggctgga gctaggcgag gccctggcgc tggggtcggg ctggcgtcat     60
 gcgtgccacg ctctcctcta cgcgccggac cctgggatgc tcttcggccg catcccgctg    120
 cgctacgcca tactgatgca gatgcgcttc gatggacgcc tgggcttccc cggcggattc    180
 gtggacacgc aggacagaag cctagaggac gggctgaacc gcgagctgcg cgaggagctg    240
 ggcgaagcgg ctgccgcttt ccgcgtggag cgcactgact accgcagctc ccacgtcggg    300
 tcagggccac gcgttgtggc ccacttctat gccaagcgtc tgacgctcga ggagctgttg    360
 gctgtggagg ccggcgcaac acgcgccaag gaccacgggc tggaggtgct gggcctggtg    420
 cgagtgcccc tgtataccct gcgggatggt gtaggaggcc tgcctacctt cctggagaat    480
 tcctttattg gctctgcgcg ggagcagtta cttgaagctc tccaggactt gggactgctg    540
 cagtctggct ctatttcagg ccttaggatt ccagctcatc actagaggca gccctccatg    600
 gacccatgaa aactgagatg aggaccttgg tactagggag ggagggaagg acctccgaat    660
 gttctcccat cgtctcctcc tgtcgcatcg tggggtcatc tgctaacacc gcgctcatct    720
 ccccctcagg ttctcgctct tagcaccccc gtccctacgc cgtccatccc tcttcctgct    780
 tccatcgtct ctcaacaacc cctttgctcc gcttcgc                             817



      <210> 2256
      <211> 1143
      <212> DNA
      <213> Homo sapiens


      <400> 2256
 atgaccggct tcccgtttca ggcagaaacc actgtctatg ttattgtgag atgtaagctg     60
 gatgacaggg tggcgacaga agcagagttt tctcctgagg attctccctc tgtaaggatg    120
 gaagccaagg tggagaatga gtacaccatt tcagtgaagg ctcccaacct ttcatctggg    180
 aacgtttctc tgaagatata ttctggagac ttagtggtgt gtgaaaccgt tatcagctat    240
 tatactgaca tggaagaaat tgggaattta ttgtccaatg ccgcgaatcc tgtggaattc    300
 atgtgtcagg cctttaaaat tgtgccctac aacacagaga cccttgataa actgctaacc    360
 gaatccctga agaacaatat ccctgcaagc ggactgcacc tctttggaat caaccagctg    420
 gaagaagaag atatgatgac aaatcagagg gatgaagagc tgcccaccct gttgcatttt    480
 gctgcgaagt atggactgaa gaacctcact gccttgttgc tcacctgccc aggagccctg    540
 caggcgtaca gcgtggccaa caagcatggc cactacccca acaccatcgc tgagaaacac    600
 ggcttcaggg acctgcggca gttcatcgac gagtatgtgg aaacggtgga catgctcaag    660
 agtcacatta aagaggaact gatgcacggg gaggaggctg atgctgtgta cgagtccatg    720
 gcccaccttt ccacagacct gcttatgaaa tgctcgctca accccggctg tgacgaggat    780
 ctctatgagt ccatggctgc ctttgtccca gctgccactg aagacctcta tgttgaaatg    840
 cttcaggcca gtacatctaa cccaatccct ggagatggtt tctctcgggc cactaaggac    900
 tctatgatcc gcaagttttt agaaggcaac agcatgggaa tgaccaatct ggagagagat    960
 cagtgccatc ttggtcagga agaagatgtt tatcacacgg tggatgacga tgaggccttt   1020
 tctgtggacc tggccagcag gccccctgtc ccagtgccca gaccagagac cactgctcct   1080
 ggtgctcacc agctgcctga caacgaacca tacattttta aaggcaagta tggcagggaa   1140
 tga                                                                 1143



      <210> 2257
      <211> 2773
      <212> DNA
      <213> Homo sapiens


      <400> 2257
 acgcgctggg ccgcgggcag cgtcgcctca cgcggagcag agctgagctg aagcgggacc     60
 cggagcccga gcagccgccg ccatggcaat caaatttctg gaagtcatca agcccttctg    120
 tgtcatcctg ccggaaattc agaagccaga gaggaagatt cagtttaagg agaaagtgct    180
 gtggaccgct atcaccctct ttatcttctt agtgtgctgc cagattcccc tgtttgggat    240
 catgtcttca gattcagctg accctttcta ttggatgaga gtgattctag cctctaacag    300
 aggcacattg atggagctag ggatctctcc tattgtcacg tctggcctta taatgcaact    360
 cttggctggc gccaagataa ttgaagttgg tgacacccca aaagaccgag ctctcttcaa    420
 cggagcccaa aagttatttg gcatgatcat tactatcggc cagtctatcg tgtatgtgat    480
 gaccgggatg tatggggacc cttctgaaat gggtgctgga atttgcctgc taatcaccat    540
 tcagctcttt gttgctggct taattgtcct acttttggat gaactcctgc aaaaaggata    600
 tggccttggc tctggtattt ctctcttcat tgcaactaac atctgtgaaa ccatcgtatg    660
 gaaggcattc agccccacta ctgtcaacac tggccgagga atggaatttg aaggtgctat    720
 catcgcactt ttccatctgc tggccacacg cacagacaag gtccgagccc ttcgggaggc    780
 gttctaccgc cagaatcttc ccaacctcat gaatctcatc gccaccatct ttgtctttgc    840
 agtggtcatc tatttccagg gcttccgagt ggacctgcca atcaagtcgg cccgctaccg    900
 tggccagtac aacacctatc ccatcaagct cttctatacg tccaacatcc ccatcatcct    960
 gcagtctgcc ctggtgtcca acctttatgt catctcccaa atgctctcag ctcgcttcag   1020
 tggcaacttg ctggtcagcc tgctgggcac ctggtcggac acgtcttctg ggggcccagc   1080
 acgtgcttat ccagttggtg gcctttgcta ttacctgtcc cctccagaat cttttggctc   1140
 cgtgttagaa gacccggtcc atgcagttgt atacatagtg ttcatgctgg gctcctgtgc   1200
 attcttctcc aaaacgtgga ttgaggtctc aggttcctct gccaaagatg ttgcaaagca   1260
 gctgaaggag cagcagatgg tgatgagagg ccaccgagag acctccatgg tccatgaact   1320
 caaccggtac atccccacag ccgcggcctt tggtgggctg tgcatcgggg ccctctcggt   1380
 cctggctgac ttcctaggcg ccattgggtc tggaaccggg atcctgctcg cagtcacaat   1440
 catctaccag tactttgaga tcttcgttaa ggagcaaagc gaggttggca gcatgggggc   1500
 cctgctcttc tgagcccgtc tcccggacag gttgaggaag ctgctccaga agcgcctcgg   1560
 aaggggagct ctcatcatgg cgcgtgctgc tgcggcatat ggacttttaa taatgttttt   1620
 gaatttcgta ttctttcatt ccactgtgta aagtgctaga cattttccaa tttaaaattt   1680
 tgctttttat cctggcactg gcaaaaagaa ctgtgaaagt gaaattttat tcagccgact   1740
 gccagagaag tgggaatggt ataggattgt ccccaagtgt ccatgtaact tttgttttaa   1800
 cctttgcacc ttctcagtgc tgtatgcggc tgcagccgtc tcacctgttt ccccacaaag   1860
 ggaatttctc actctggttg gaagcacaaa cactgaaatg tctacgtttc attttggcag   1920
 tagggtgtga agctgggagc agatcatgta tttcccggag acgtgggacc ttgctggcat   1980
 gtctccttca caatcaggcg tgggaatatc tggcttagga ctgtttctct ctaagacacc   2040
 attgttttcc cttattttaa aagtgatttt tttaaggaca gaacttcttc caaaagagag   2100
 ggatggcttt cccagaagac actcctggcc atctgtggat ttgtctgtgc acctattggc   2160
 tcttctagct gactcttctg gttgggctta gagtctgcct gtttctgcta gctccgtgtt   2220
 tagtccactt gggtcatcag ctctgccaag ctgagcctgg ccaagctagg tggacagacc   2280
 cttgcagtga tgtccgtttg tccagattct gccagtcatc actggacacg tctcctcgca   2340
 gctgccctag caaggggaga cattgtggta gctatcagac atggacagaa actgacttag   2400
 tgctcacaag cccctacacc ttctgggctg aagatcaccc agctgtgttc agaattttct   2460
 tactgtgctt aggactgcac gcaagtgagc agacaccacc gacttccttt ctgcgtcacc   2520
 agtgtcgtca gcagagagag gacagcacag gctcaaggtt ggtagtgaag tcaggttcgg   2580
 ggtgcatggg ctgtggtggt gttgatcagt tgctccagtg tttgaaataa gaagactcat   2640
 gtttatgtct ggaataagtt ctgtttgtgc tgacaggtgg cctaggtcct ggagatgagc   2700
 accctctctc tggcctttag ggagtcccct cttaggacag gcactgccca gcagcaaggg   2760
 cagcagagtt ggg                                                      2773



      <210> 2258
      <211> 993
      <212> DNA
      <213> Homo sapiens


      <400> 2258
 cggacttccc gggtcgacga tttcgtaaat tcacatcccg atcaccctgt atcccagcat     60
 cttgacattt ccgtggcaac caaagacggg cgcctatcag tacacaataa gggcccacgg    120
 tggcagtggg aacttcagct ggtcttcgtc aagccacctg gttgccacag ttactgtcaa    180
 gggcgtgatg accacaggca gtgacatcgg gttcagtgtg atccaggcac atgatgtgca    240
 gaacccactc catttcggtg agatgaaggt gtatgtgatc gagccccaca gcatggagtt    300
 tgccccgtgc caggtggagg cacgtgtggg ccaggccctg gagctgcccc tgaggatcag    360
 tggcctcatg cccggcgggg ccagtgaggt ggtcaccttg agcgactgct cccactttga    420
 cttggctgtc gaggtggaga accagggtgt gttccagcca ctcccaggga ggctgccgcc    480
 aggctctgag cactgcagcg gcatccgggt aaaggccgag gcccagggct ctaccacgct    540
 tcttgtgagc tacagacacg gccacgtcca cctgagtgcc aagatcacca ttgctgccta    600
 cctgcccctc aaggctgtgg atccctcctc tgttgccttg gtaaccctgg gctcctcaaa    660
 ggagatgctg tttgaaggag gtcccagacc ttggatcctc gagccgtcca aattcttcca    720
 gaacgtcacc gctgaggaca ctgacagcat cggcctggct ctctttgccc cccattcctc    780
 ccggaattat cagcaacact ggatccttgt gacctgtcag gccttgggtg agcaggtcat    840
 cgccctgtcg gtggggaaca agcccagcct caccaacccc tttcctgcgg tggagcctgc    900
 cgtggtgaag ttcgtctgcg ccccaccgtc caggctcacc ctcgcgcctg tctacaccag    960
 cccccagctg gacatgtcct gtccgctgct gca                                 993



      <210> 2259
      <211> 906
      <212> DNA
      <213> Homo sapiens


      <400> 2259
 gcccatctgc tcacatttct atcactgcag ctcacagact tcggttgtct ttcacacccc     60
 aggtaagatc aactgctaaa accaacaatg ccttgacatc cttctacatg aatccacata    120
 aggagaccag aaggcaggag gggccagcca cagctgccac ctttgcctct cctcttctca    180
 gggtccgtat gccattacca ggagcgatca ggtgggccga ggacatttgc ttgcttcacc    240
 ttccctgttt ctttagattg aaattcagcc tgccccactt ctcaggaaga tgccacgagg    300
 ctgatccccc tgagcagttt gtcctgtcct cttttcactg gttttcttcc tcattacctg    360
 ggccaatcca acataaaatt gataaattgg acttcatcac aattaaaagt ttttgtgcat    420
 caaaggacac tatgaagaaa gtgagtcctg caaatcaccg catacctcta agtgatggaa    480
 acagcattcc catcatcaga cttggtacct actcacttcg gaagcttgta aagatgctgg    540
 cttggtgaaa tccctcggag tatccagttt taacagcagg ccagctggag ctcatccaga    600
 acaacccagg actcaaaccc aagccagtca gcaacgaggt tgagtgccac ccatattaca    660
 cccaaccaaa acttttgaaa tttcgccaac aacatgacat tgtcatgatt gcatatagcc    720
 ctttggggac cactaggaat ccaacctgga caaatatgtc ttctctgcct tcgttaaagg    780
 atgcacttct aaaaaggtgc aataagatca cagctcaagt tattttgcgt ttcaacatcc    840
 agcaaggggt ggttgtcatt cctaaaagct ttaatcctga aaagatcaag gaaaaccttc    900
 aggcct                                                               906



      <210> 2260
      <211> 379
      <212> DNA
      <213> Homo sapiens


      <400> 2260
 ggcgtatttc agtagatatt agatacatca cccatgagat ggacacaaaa aaatttttca     60
 atgattttgg cgcagcccga gcaacagtgc aagactctgt ctcaaaacaa aaacaaagac    120
 agaagaataa agaagaagga ggagaagaag aagaagaaga agaagaagaa gaagaagaag    180
 aagaagaaga agaagaagaa gaagaagaag aagaagaagt aggagaagga gaaggagaag    240
 gagaaggaga agaagaagga gaaggaggag gagaagaaga agaagaagaa gaagaagaag    300
 aagaagaaga agaagaagaa gaagaagaag aagaagaaga agaagaagaa gaagaagaag    360
 aagaaagaag aagaagaag                                                 379



      <210> 2261
      <211> 2039
      <212> DNA
      <213> Homo sapiens


      <400> 2261
 aacaaaagaa aacattttat tgcaatttga ttaacaagga gacaggagcc cagctcaaat     60
 ctgtcccatt gtacttattt taaagagtta ttttagtaga aaaggtgtag ggagtggatt    120
 ctgtgattag taggtgattg atagaaagat ttgtttgggc tggaaaatcc tcgggccatg    180
 gggcagttaa cctcttcatg ccctcctcat gggtccccat gtgcaaactc cagagggagt    240
 taagtatgaa acatgcggta caaatttagg ctgtgtgtca gcaagctcat tctgtacaaa    300
 ctctggtttt atctctttat cttgacacct gaagggtgtg cataatccca tcactcccca    360
 aaatatgccc tacatgcaga atttaaattc atcctgcctc cttgactctg agggccactt    420
 cctaccacag ctagggtccc ttttctgtca gcattctttc tggagcttgc ttatatcaaa    480
 cctaagaaaa gcaactccag gactccagac aaaacagatc tccacccatc tggcggccag    540
 aaagggaagc tctgggcaaa gagggagaga gaatcaacct cactcactct ggatgggcct    600
 cctgtgtgtt cacagaggac agagcagagt cccccagctc atcctcaata tcagcgtccc    660
 cagactggct taggtcctgc tagaagaacc caggattttg cctggcagaa agacacaaga    720
 cctttgccag gatcagcctg gtctctcacc aattcatgtc aggtgaagac ttatagtgga    780
 gctgtttaaa tccttagaaa aatgatttta aatgccttga agtccaaatg actttggagt    840
 gctaaaattt cataagtttc catgcctagc acatagaaaa gggaagctgg ggtttcatgg    900
 gcatgtttgt ctaatacctt ccatctacac aacctcacac gcacatcaca aagcatcaca    960
 aagactctaa tttctccaac gcttggtgga atcacctgtc caggtacaga taggctgcca   1020
 caccgatgac cttaccaagg ccaggaagct atctcgagcc cccgtggtga ctcaccaatg   1080
 ctggatggac aggactgagc ggtcagtctc ctgcctctgg ggcggcctcc tctacgtcat   1140
 cgtgcccaag ggcagccaac taggccctgt gcctgtcact atcaggggag ctgtgcctgc   1200
 cccatactac aagctgggta agtggagtga acatttaggg aggaggaaga gtggcagatg   1260
 ccgtgggaac tgtggggtgg ttgctaaatg ggagagggat gagctttggt ggagagaaag   1320
 aggaagaact gttgggaggg aacatggagg cagaagatac ggaataccct gtgtccatgg   1380
 agacttcagg gcagacaaag agaagagtca ggaagccttt tcttcccttt acagcctata   1440
 gacgcctgtg atagtagttc attattgcaa tgttcttcca gagttcaaat ggtatttttc   1500
 agctcaaggg aagttggaga agtgggtgtg gtaggttcca tgatatttat tcccaggtaa   1560
 gacatcgctg gaggagtgga agaggcagat gcaggagaac ctggctccct ggggagagct   1620
 ggccacggac aacatcatcc tgacagtgcc aaccacaaac cttcaggccc tgaaggaccc   1680
 cgagcctgtg ctccgcctct gggatgagat gatgcaggct gtggccaggc tggcagctga   1740
 gcccttccct ttccgccgtc ctgagaggat tgtggctgat gtgcagatct cagctggtgg   1800
 gtgctcccag ggaatcctcc tgtaatccca gctactcagg aggctgagac aggagaatcg   1860
 cttcaaccca ggaggcagag gctgcagtga gccaggatcg caccattgca ctccagcctg   1920
 ggcaacaaga gtgaaacttg ttttagcgtt ccgattttgc ttttgtcttc atgctgcacc   1980
 tcatcttcct tttaagcttt cagaataaac attccattcc tttacccctg agcagtgcg    2039



      <210> 2262
      <211> 1010
      <212> DNA
      <213> Homo sapiens


      <400> 2262
 cggacgcgtg ggcggacgcg tgggcgtagc tgtcggagcg gttagttcga tttcgagctc     60
 gaggtttccc ccgccgccag gctgacttct catcgcttgt ttttcttttt gcatttttcc    120
 tcccaccgcc gttgccgccc tccccgtcct ggccgtccgc cctccgccct ctgcagggac    180
 atctctacac cgttcccatc cgggaacagg gcaacatcta caagcccaac aacaaggcca    240
 tggcagacga gctgagcgag aagcaagtgt acgacgcgca caccaaggag atcgacctgg    300
 tcaaccgcga ccctaaacac ctcaacgatg acgtggtcaa gattgacttt gaagatgtga    360
 ttgcagaacc agaagggaca cacagttttg acggcatttg gaaggccagc ttcaccacct    420
 tcactgtgac gaaatactgg ttttaccgct tgctgtctgc cctctttggc atcccgatgg    480
 cactcatctg gggcatttac ttcgccattc tctctttcct gcacatctgg gcagttgtac    540
 catgcattaa gagcttcctg attgagattc agtgcatcag ccgtgtctat tccatctacg    600
 tccacaccgt ctgtgaccca ctctttgaag ctgttgggaa aatattcagc aatgtccgca    660
 tcaacttgca gaaagaaata taaatgacat ttcaaggata gaagtatacc tgattttttt    720
 tccttttaat tttcctggtg ccaatttcaa gttccaagtt gctaatacag caacaattta    780
 tgaattgaat tatcttggtt gaaaataaaa agatcacttt ctcagttttc ataagtatta    840
 tgtctcttct gagctatttc atctattttt ggcagtctga atttttaaaa cccatttaaa    900
 tttttttcct taccttttta tttgcatgtg gatcaaccat cgctttattg gctgagatat    960
 gaacatattg ttgaaaggta atttgagaga aatatgaaga actgaggagg              1010



      <210> 2263
      <211> 4220
      <212> DNA
      <213> Homo sapiens


      <400> 2263
 aaaggaggaa gaaggagatt gtgatggaga aagggggtct gtgaaacgtc aggcacagca     60
 caaaggcttt gccacgtaat tacaggctcc tattaagtcg agatctgccc tcccaggggt    120
 ctccaatttt cttgtattcc ctacaaagcc tcctctgcat gccagtttgt gccttttgaa    180
 gtgccagaga gcttcttgat ccaactgaga aggaaaaagg agcccagcaa gaagaggggg    240
 agagagagaa gggaaagggg ggaacccacc agcaccctcc gtcggactct tgaagccttt    300
 ttttttaatt cttaattttt ttttttactc tttacaaaaa gtaaagtgag aatcctgctc    360
 tctaatacat ctgcaagaca tcaccctctc ctcctgaaac tttagtcact cctgagaatc    420
 cacaggagtg cagagagggg ggaacacgtt ttcttgaaga tgttttaaag ctggaacaag    480
 ccttcttctg ttggtgcttg aactcttgcc tgggaataac ttttttaacc tttaaaaaaa    540
 ccattcactt tgattcttct ctcccacccc ttcttctctc ttcttctgtt tgcctaactc    600
 ccccgccctg ctggcctccg ctttcctctc tcccccttgt tgttattttt agtctgtgcg    660
 tgtggacact tttggagagt tggaagggat ttttttctcc tgacttgaac atagggtgac    720
 tttttaatat tgtattttag tgtggattat ctctttggac cgcgccggac ttggcctcag    780
 gaaagcaacc aaggctgcgg aaggcggctg gtgcagaacg ctctgctcta cagaaggggg    840
 tcccccgccc tcttttccaa tttttttttt tggccttcct ctccttccct ccctcttcct    900
 ccctctctct ctctctctct ccactacccc cctttttttt ccccactcgg ctcctctccc    960
 ccctcgcgcc cacagcgttt ggtgttgatt cgagcgggaa gaggggggtg ggtgggatcg   1020
 gtgggggaga ccatgacctc cagctacggg cacgttctgg agcggcaacc ggcgctgggc   1080
 ggccgcttgg acagcccggt caacctcgac accctgcagg cgaaaaagaa cttctccgtc   1140
 agtcacctgc tagacctgga ggaagccggg gacatggtgg cggcacaggc ggatgagaac   1200
 gtgggcgagg ctggccggag cctgctggag tcgccgggac tcaccagcgg cagcgacacc   1260
 ccgcagcagg acaatgacca gctgaactca gaagaaaaaa agaagagaaa gcagcgaagg   1320
 aataggacaa ccttcaatag cagccagctg caggctttgg agcgtgtctt tgagcggaca   1380
 cactatcctg atgcttttgt gcgagaagac cttgcccgcc gggtgaacct caccgaggcg   1440
 agagtgcagg tgtggtttca gaaccgaaga gccaagttcc gcaggaatga gagagccatg   1500
 ctagccaata aaaacgcttc cctcctcaaa tcctactcag gagacgtgac tgctgtggag   1560
 cagcccatcg tacctcgtcc tgctccgaga cccaccgatt atctctcctg ggggacagcg   1620
 tctccgtaca gatcctcgtc cctcccaaga tgttgtttac acgaggggct tcataacgga   1680
 ttctaacgga agacactgaa aagcgccatg gctacttatt ctgccacatg tgccaacaat   1740
 agccctgcac agggcatcaa catggccaac agcattgcca acctgagact gaaggccaag   1800
 gaatatagtt tacagaggaa ccaggtgcca acagtcaact gagtgaaaaa aaataattaa   1860
 acaggcccta aggaagaaat caaaaaccat aagacaccta tcctgctctg ttatttcttc   1920
 atctgctggg gggaaaaagt aaattacaaa caaacaaaca aagcagaact aaaatattgg   1980
 gaccatggca gagaaaagca ggagaggagc aaaatgaaaa ttagttaaca aatgttccgt   2040
 cgctccctct gggataccac caccacttgt ttctgtgtgt gtttattttg tttttctttc   2100
 attcatgctt tgcttaatgt actccaggct tcttcagcta ggttcagccc acccaccccc   2160
 atgattgtat gaagttttaa aaaaaactac agcagccaaa gaaactatat atatatatat   2220
 atatatatat atccagaatg attgcctcta ctgtcctcat tgacttgttt gaaccttagt   2280
 gccttaccct gtcctcttcc cagttctctt tatagaagct ctaggagctt tcgaaaagcc   2340
 aaagtctttc tgaagaatct gtgctggaca gacataattc cctttctcat tgtctccatc   2400
 tttgttggtc atggtaaggt ttttccatca gcctctgaaa aaatagttgt gcacaacatc   2460
 tgctcactgg actgtctgat ccaatgtaat tggctgcgtc tggctaattc taagcactaa   2520
 agtctacatc taagctatag atttaagctt gaagctacag attatatcac tatcaccacc   2580
 accccccacc ctatgcaatc aatcaatcaa tcatcttaag ttaaagatat ttgttgtctt   2640
 tgaatgattt gctgtcacag actatttggt agaagaaata tttttcacct gagagaggaa   2700
 gagaaatttc tctagtaaca caaagagtga gttctaaaag gcatgcccac atctctttcg   2760
 tgccttaagg atagtgagat gcacacttat atatatactg tatatattta tatatttata   2820
 tatatatttc atatatatat ataatattgc aagcttaagt ttgcaatttc ccaaacaata   2880
 caaaaagcaa attacacacc ctcaccactg ttcttatctc tatagtgatg aaacattaat   2940
 tagggatctt gctgcttttc tttttctaca cgaagttttc attaaagcca cagaataatt   3000
 gatagggcag ctgtttgaga acaggtccca ttttcacatt agggctttaa atgaattaga   3060
 aactatttga ggctataaaa atgtccttga gtttggagcc tgagctctgg tgaaatgctg   3120
 atacatctga tctatcatgg gaattgcagt tagagagagt aaggaatacc atttagtcat   3180
 ctatccgttc ttcacttagc aggaatatga aagaaaggca catgtttaag aggaatacct   3240
 aaaggttttt ctaaattcca acatttaaaa ggcaattgtg ggctattttt attttttaat   3300
 attttgaaat aaagtttagt gtctagggct gggagccagg actgatcttc catttctttt   3360
 tctttgttcc cagccatgct tttgtaactt gccaggtgga cttgaccaac tacattacca   3420
 tgctgtgcct cagtttaccc atttgtaaaa tgggattaat aatacttacc tacctcacag   3480
 gggtgttgtg aggctctatt catttgctcc tttattcttt cctgtattct ctgtatgtcc   3540
 agcactttgt agccatggga ggaaagggac tataaaagtg tacaatgtta atggaatgat   3600
 acggtacctg aaagccttgt tttctagtaa gaaaatgcta ccttgctgta catacttata   3660
 accttgtatt tggaaatgag aaataggttt atattttcag atctctcaaa aatcacatca   3720
 tttgaccaaa gaataattta agacacatag aacagatttt tttaatttat attttcatcc   3780
 tgaccagctt agttctaata atttttagtt gtgagtgatt aaaaaacttt ggatcaattt   3840
 tggtcaaaca tgccaacttt gtagtctgag tgacaggcaa ggatttttgg gtttaagatg   3900
 cacttttagc acacatttgt atttcccttg gcatatcaaa ttgagctaat ggtgatgtta   3960
 tttcaatcta acagccacca atctgaaatt gtatttcaaa tgttgattct gtagttcttt   4020
 aaataataat gaagctcatc ttatacattt tgctttcacc aattgattcc ttcttctttt   4080
 agcccactat taaaacattt cttactgaat gggtcatgta ggcttgctga acggcacgcc   4140
 attactggct tcccggaagg ggtcccccat tcatccattg ggcccaatag gttgccgggg   4200
 atatcaaggt tggaagggac                                               4220



      <210> 2264
      <211> 1437
      <212> DNA
      <213> Homo sapiens


      <400> 2264
 atggggaaaa aacagaacag aaaaactgga aactctaaaa agcagagcac ctctcctcct     60
 ccaaaggaac gcagttcctc accagcaatg gaacaaagct ggacagagaa tgactttgac    120
 gagctgagag aagaaggctt cagacgatca aattactctg agctacggga ggacattcaa    180
 accaaaggca aagaagttga aaactttgaa aaaaatttag aagaatgtat aactagagta    240
 accaatacag agaagtgctt aaaggagctg atggagctga aaaccaaggc tcgagaacta    300
 cgtgaagaat gcagaagcct caggagccga tgcgatctac tggaagaaag ggtatcagca    360
 atggaagatg aaatgaatga aatgaaattt caattaaaag gcagctctgc tagttactgt    420
 gttttggctg gaatggaaag cctttggaat agcagtgttc cagtgtgtga acgtaaatca    480
 tgtgaaactc ctccagttcc agtgaatggc atggtgcatg tgatcacaga catccatgtt    540
 ggatccagaa tcaactattc ttgtactaca gggcaccgac tcattggtca ctcatctgct    600
 gaatgtatcc tctcaggcaa tactgcccat tggagcacga agccgccaat ttgtcaacga    660
 attccttgtg ggctaccccc aaccatcgcc aatggagatt tcattagcac caacagagag    720
 aattttcact atggatcagt ggtgacctac cgctgcaatc ttggaagcag agggagaaag    780
 gtgtttgagc ttgtggtgtg tcagccgcct ccagaaatcc tgcatggtga gcatacccca    840
 agccatcagg acaacttttc acctgggcag gaagtgttct acagctgtga gcctggctat    900
 gacctcagag gggctgcgtc tctgcactgc acaccccagg gagactggag ccctgaagcc    960
 ccgagatgtg cagtgaaatc ctgtgatgac ttcttgggtc aactccctca tggccgtgtg   1020
 ctatttccac ttaatctcca gcttggggca aaggtgtcct ttgtctgtga tgaaggccgc   1080
 gacacagccg tcccccatta tgcctttccg gccgttgccc ttcgactttt ccccgtcaca   1140
 tctttgattc tgtcctacct cattttttca ggggacctgc agaatggaat cacaggaagt   1200
 cctcctacag actcatcagg gatattacct tggtatgagc cagaggacaa gctgaaaacc   1260
 agagtggttt gctctcctaa aagccaagga gtgagaactc ttcaggcaga agagagtgag   1320
 ggcagagtga tcagtagctc tcacgttatc aagagggtaa ttcaaactat taaggaagag   1380
 actgttagga ggagtttaac aaggaggagg ccctttaatg actcagaaag tagttga      1437



      <210> 2265
      <211> 3282
      <212> DNA
      <213> Homo sapiens


      <400> 2265
 gtgcgctcag gcggcgctcc cggagatgcc ccgcggcagc cgcgctcggg gctctaagag     60
 aaaaaggagt tggaatacag aatgcccatc ctttccagga gaaagaccac tgcaggtcag    120
 aagagcaggt ctcaggacag caggggcagc tgcctctctc tctgaagcat ggctcaggtg    180
 tggagaaggg tttcagaaca cttctgggaa tccgtcatta acagctgaag agaagacgat    240
 tacagaaaag caccttgaat tatgccctag acccaagcaa gaaaccacca catctaaaag    300
 caccagtggg cttacagaca taacatggag ctccagtgga agtgatttgt cggatgaaga    360
 taagacactt tctcagttac agagagatga attacagttt atcgactggg agattgacag    420
 tgacagggca gaggctagtg actgtgatga atttgaagat gacgagggtg ctgtggaaat    480
 ctcagactgt gcttcttgtg caagtaatca gtctttgaca agtgatgaga agctgtcgga    540
 gcttcccaag ccaagttcta tagaaatttt agagtattca tcagatagtg aaaaagaaga    600
 tgatttggaa aatgtcctac tcattgattc agaatcccct cacaaatacc acgtgcagtt    660
 tgcatcggat gcaagacaga ttatggagag actgatagat ccaaggacaa aatcaacaga    720
 gaccattttg catacacctc agaaacccac agctaagttt cccaggactc cagaaaattc    780
 agcaaagaag aagcttttaa gaggtggact agcagaaaga ctaaatggac tgcagaatcg    840
 agagagatct gctatttctt tgtggagaca tcaatgtatt tcttaccaaa agacactttc    900
 aggtagaaaa tctggtgtat taactgtgaa aattttagag ctgcatgagg aatgtgccat    960
 gcaagttgcc atgtgtgagc agttattggg gtcaccagcc accagctcct cccaaagtgt   1020
 ggctcccagg cctggagctg gcctgaaagt tctcttcacc aaggagactg caggctacct   1080
 caggggccgt ccccaggaca ctgtccggat cttccctccc tggcaaaaac tgattattcc   1140
 aagtggaagt tgccctgtta ttctgaatac ttacttttgt gagaaagttg ttgccaaaga   1200
 agattcagaa aaaaacttgt gaagtgtact gtccggacat accccttcca agaagaagca   1260
 tctctttggc ccagatgttt gtaattaagg gtctaacaaa taattcacct gaaatccagg   1320
 ttgtgtgtag tggtgtagcc actacaggga cagcctggac ccatgggcac aaagaagcaa   1380
 aacagcgcat cccaaccagc actcccctga gggattctct cctggatgtg gtggaaagcc   1440
 agggagctgc ctcgtggcca ggagctggag tccgagtggt ggtgcaaaga gtgtattctc   1500
 ttcccagcag agacagcacc aggggtcagc agggggccag ctcaggacac acagacccag   1560
 ctggaactcg agcctgcctt ctggtacaag atgcctgtgg aatgttcggt gaagtgcact   1620
 tggagttcac catgtcgaag gcaagacagt tggaagggaa gtcttgcagc ctggtgggaa   1680
 tgaaggttct acagaaagtc accagaggaa ggacagcggg gattttcagt ttgattgaca   1740
 ccctgtggcc cccagcgata cctctgaaaa cacctggccg cgaccagccc tgtgaagaga   1800
 taaaaactca tctgcctcct ccagccttgt gttacatcct cacagctcat ccaaatctgg   1860
 gacaaattga tataattgac gaagacccca tttataagct ttaccagcct ccagttaccc   1920
 gctgcttaag agacattctc cagatgaatg atcttggtac ccgttgcagt ttctatgcca   1980
 cggtgattta ccaaaaacca cagctgaaga gtctgctgct tctggagcaa agggagatct   2040
 ggctgctagt gaccgatgtc actctgcaaa cgaaggagga gagagacccc aggctcccca   2100
 aaaccctgct ggtctatgtg gcccccttgt gtgtgctggg ctctgaagtc ctggaggcac   2160
 tcgctggggc tgcccctcac agcctcttct tcaaggacgc tctccgtgac cagggtcgga   2220
 ttgtttgtgc tgaacgaact gtcctcttgc ttcagaagcc ccttttgagt gtggtctctg   2280
 gtgcaagttc ctgtgagctg cctggcccgg tgatgctcga cagcctggac tctgcaacac   2340
 ctgtcaactc catctgcagt gttcaaggca ctgtggttgg cgtggacgag agcactgctt   2400
 tctcatggcc tgtgtgtgac atgtgtggca acgggagatt ggaacagagg ccggaagaca   2460
 gaggcgcctt ttcctgtggg gactgctccc gggtggtcac atctcctgtt ctcaagaggc   2520
 acctgcaggt cttcctggac tgccgctcaa gaccgcagtg cagagtgaag gtcaagctgt   2580
 tgcagcgcag catttcctcc ctgctgaggt ttgccgccgg tgaagatggg agctacgaag   2640
 tgaagagtgt cctcggaaag gaagtggggt tgctaaattg ttttgtccag tccgtaaccg   2700
 cccacccgac cagctgcatt ggattggagg aaatcgagct tctgagtgca ggaggggcct   2760
 cctgccagaa cactagccgg ttgccgcagg atctgtgaac tttgcaatgt ggcctgccaa   2820
 ggggtggtgg gtggtggtgg tgattggggg gtaggttatt gggttaacct atgggacccc   2880
 agtgaaccgt aggtttacgg atcttggaaa ggaaacttta gatttttctg gggaaatgtt   2940
 ccagatacca gttttgtgaa ctgttaaatc aaaataccct ttttcctaca gtttatcttt   3000
 tattttcctg caaatttaag gaacatattt actccgtttt ccacattgaa tccttaagtt   3060
 ttaaactcct tcatttggta tttaaggcca atatatgagg aaaaaaattt ttttttgttc   3120
 atttgtaatt ttaacaagtt gaacatttta ccatgattga acatgttttt attacagtat   3180
 ttaacattcc cccaaagaat accctgcaaa gtgtaaacct ttgtcccata ctgtgatatt   3240
 aaaaattctg ctacaataaa tgtcaaacct aaaaaaaaaa aa                      3282



      <210> 2266
      <211> 1671
      <212> DNA
      <213> Homo sapiens


      <400> 2266
 atgaaaaact atgctgctga tgctgtcagc ttcccagaat cctctcccaa gttaattcaa     60
 ttgcttctag ttcaaactcc ccaggagaaa acatgtggtt ggtgtggcca gtatccactc    120
 ctactgggca gagcccttgt accaggtttt ccacaggcct ttgacctttg gatcaagcat    180
 ccagctttgg cccaatcagt tgaggcctgg gtgatgggat cacatggcag catgtacctg    240
 atgcaaggac accagtcata tcggattaag ggccaaccct gctccagtat tacagtgggg    300
 tcacctttgt gggagagttc agccaccaac agctgggcag ccacagaaac catgacttat    360
 caggacagga gcagaataat gaattaccca cttgcaaatt ccaagggaag tttgaaagcc    420
 tggatttttt ccaggtctct tgaggttgag aagtccaaga tcaaggcact gaatctggtg    480
 agggccttct tgctgagtca tcccacggca gaaggtggaa gggcaggagc acacacgaga    540
 gagagagaaa gagacgacaa acttggaaac tacatttccc tgatcttgcc aacagtattc    600
 agcccggact ccaccaatga gaggcacttg catgagattt ggttgggaag aaaaggagaa    660
 gccattgttt tcttgaggca gcagcagatg gctgacatgg aattttgcct aaaacttttg    720
 ggtgttctcc tgaaaatact ccaactggct ctacaggcag ctgagagcaa tggcagtggc    780
 ttccttgtga ttcctgcact accagatttc ctgaaagaga ggatgcagca acaaggcacc    840
 agcttggaag cagagatcaa acccttatca gatgccaaac ctgcttatgc cttgatctgg    900
 gacttcccag cctccagaac catgagaaat aaatttctat tgtttgtgaa ttacccggtc    960
 tatggtctgc aggaaaaggg ggaagagtct ttacaggtgg cactgtgtgg agagagccac   1020
 ccaacaggaa tggtggcctt catcaaggaa tgcagccagc ccggggaacc ctcacctcaa   1080
 ggaagcaagg cgaatcgata cttcaccctt tccttcctcc ttccctctca cgtcctgcca   1140
 gtattctcca ttggccaagc ccagcccaga atccagaaaa ccagggaatc tgctgacact   1200
 gcccatccag tgtgtcctca aacaaaagat ggccatgtca gaataccaca aaggcttgtg   1260
 gactgtgccg ctgctgatgt tggaagaaga cgtttctttg gcaagcaagg aggatttgag   1320
 cagacgaacg acttagccag aaccgggata gtgtgtgcat ggcagaaaca acggagagat   1380
 tctcgggatg tgactatggg cctacagcat ttgtcatcag tcactagtac acttcgtaga   1440
 agacctgcct tagcacaaat gctgctggaa ccgtctgagg cttgcaattt gggcagtttt   1500
 cttgtgatat ctcatatggt tgtggacaat ggctgctggg gtttggggct ggaggcatct   1560
 gaagtaacag tcgatgctgg ctgtcaacca ggagcacagc tgggctgtca actagaacgc   1620
 ctacatatgg actctccgtg tagcttggac tgtgcacagg ctggtggcta g            1671



      <210> 2267
      <211> 6566
      <212> DNA
      <213> Homo sapiens


      <400> 2267
 tttttttttt ttgctataaa cattttattt attttttaag aaagtagctt cagaaaaaga     60
 ggaaaatatc tagatcattt atttatacat atatatattt tttaataaaa acctttacat    120
 tatcttcatg cataaagacc caggtgtggc catattgcct gagatagccc taacaccagc    180
 tatctcatgc cattacctgg ggctccctat agctgtcagc agtgtagcaa aggccctctg    240
 cctgccccta acgcccaact ccatgcctgc ctcagtcatg gtttgttttt gcttctggaa    300
 ggggtagatg gagggtggga aatgctttgg agctaacatg ggatgaacag ggagggttac    360
 ccaacctgcc attttttatc caaactctgc aggcaaatcc agacagagtc tcagcaagac    420
 tgaaaaccag ggaccaaacc aaactctggg agcttcccac agacatgtca catgtgacca    480
 agggttcctg cacatagtag tagcaaaggt atggtgttca tggaactcta aaggcaggaa    540
 caaaaacagc cctgaagatc aatccctccg tgacaggcat tcacttctgc cctaagtgtg    600
 tcagaaagat cccattttgt ttcctaactc aggccaaccc tcctttgcct ccaaaattca    660
 gtgttaacta accaattact taagagacgg atccctcttc cttctgtgga tagttcatct    720
 gttaaggatc cattatcacc tgtctcactc ctcctaagga gtcctagtat aaaagggcca    780
 gggtaggagt agggaagctg gttggcatgg agggtcacaa gatccagaat ggctagggat    840
 ggaaaaagaa taccctggtt ctttggggga ttctgccaaa ggagctttat tgaccatttt    900
 tttaaaggaa aaacactgaa tgatcttgag gatggtaaac tgtctcctct tctgggttcc    960
 agaagccctt atgctacgtt cagtattaag aaaagccctg aacaagtgga ggatgctgct   1020
 tctggcagca gggagggagg gtagatgcca cagccaaccc agagaatggc aaacagtgcc   1080
 aatccaaaca aggcagggaa cctctgtgtg gtgtgaatgg gcatgtgact gtgatgcaaa   1140
 gtgcctgggg ctcacaggct cccaacagcc agttctcgca gataggactg ggtaaggctg   1200
 cgcagttcgt ccatggcata gtcctcaggc atgggaagcc ggccaatgtg gggagccaag   1260
 aggcgcaaag ggactcgctg agggtctggt gttgagtcgg aggttctatc aggaggatga   1320
 tgcagactca gcaccacgcg cagcaggttg gctacacgtt tggccatgtc tgactgagcc   1380
 aggcgatctt tagcactgta acactgaatc tgctctatcc gactgcacag tgaagtcact   1440
 ttgatgtgta actgctccag gtcattacct gagcaatcca cctgctgtat atggcggagc   1500
 atttcaatga ctctaatata gtccaggtaa acaagcccag atgtttccca atcctgaatt   1560
 aggctgctgc gctctggagg tgccaggtct tccaagaacc ccttcaggta gtcatagttc   1620
 tcattaatga tggcatcaga agctaagtgt cggatgatga gcttgtggca gcggttccag   1680
 tgctcagcct taaataagca aagggcctct aagtgcttgt cagattccat gtgtgctcgc   1740
 acagctttgg cctcgtggat ccatttggca ggtacacgga gcttctgggt aaggaaagtc   1800
 tctttagccc aagattcagg ggtctccaac agctggcagt gccgggtaag cagctctcga   1860
 acagccttct cacgtatgcc tgagttgtca atgtgcagga ggacaaagat ggcccactcc   1920
 cagagcccct cactttcaag ctggccagcg taactggcct gtagcacacc ttcacactgc   1980
 gctgagagat gggtgtagtt aagagccctc agcacttccc acaagtgcca gcttaggcgg   2040
 tagtccaaag gatctgctgt tatgctttcg gaggctccag caagcttggt tgagatcata   2100
 atgtctgtca cttgtacgag ttttacgaag gtgaaagcag acatctcgaa gtggtgtctg   2160
 gtaagttttg ttcctccggc tatcacacag ccagaaccct ccagatacga aggaagtggg   2220
 gagcaggcat atctgtcact gtcagaggta ttctgaaatg cttcttcata caatgctgag   2280
 cgccctagaa atggaggctg ttggtggaag caaataccaa agatggatag ccagggagcg   2340
 tttccaatcc aactgggagc acacgtttat ttgcttcttt tctgagagct gccacaccgg   2400
 ttttccagcc aacagagcaa agatgcgcag tctctcatcc tggatgaagg agtctgcttg   2460
 gagctgatgc cagtccacca actgcatggt gagcagctcc cggactgact ggctacccac   2520
 aaactgagat aaaagaagag caagacgatg atcccctgac tgctgggcca gagagcaggc   2580
 ctcactgatc cttttgcctg tgaggtagct gaatacagcc tccacagggc tgtttttttg   2640
 ggttaaggag acttcctctt caatctgagg tgtggcagta caggatagcc agcgggagaa   2700
 agctcttctt cgctccagaa tttgaatgta ttcacggggt tcatttagct ggctgtcaag   2760
 ctccttcagg tgggcccata gggcttcaca tagtgtccat gtcaggctcc agtgcttcac   2820
 aatttgtgct tctggtaagt ctcctgatgc ttctttaacc caatctgcat agtcatgaat   2880
 gacagcaact cccagattgg ggacaatgag aggacacagt tcatccacat ggacagtgct   2940
 gtgttttaat ttgagctcca gaggtgtctg atataatttc atgtcttcat ctggctttct   3000
 ttgtctcaaa ctgagttttt ctaagtgaac tttgaatggg gactcagtta ggggtttaac   3060
 agctactgga ttgggcagga atccaaactc catggaatcg gcaatctgat gattttctag   3120
 ttcatgagag ccattcagct gttctccact attagcaaga gtccagttgg ggccccaacc   3180
 aacacgaaat gagcgtccca tgaatagggc catgtccatc aagagttttc ccttgccata   3240
 ggtgacagac ttttcacgag ggactaggcc tagttgccta cgtgtaccca ctgttttcaa   3300
 cggaacctca ggggctgggc tgggcattgt gaacacagaa gtcaggggtg gagggacaga   3360
 ccaagaggat gtggatggga tattcattaa agatgctgct ctgggagtac gacattcttg   3420
 cacagagaca cttgggtgaa agaaaagctc ccacttgtaa attttgattg tagtaaccca   3480
 ccaactagtg aacgagtttt cgacgagtgg gatgctgaaa tggggagtct gggagaacag   3540
 atttcttgag aagtatctgc tttggaaggc aggcgactga agcgttgatc cagtgccata   3600
 tctacatctt cttcatcagt aagcaatgat gctttcatga tctgtaagac atgtggatta   3660
 attcccagtg aagatgcaat atgtgttgag gcagacacag gttcctgatc ctcaggcatg   3720
 ctctcttcta acatggtatc caaaactggc tcctgggtga tatctaccat gtcactgtcc   3780
 agttccacaa ccctccctaa ctgctccacc tctgggctct ggctctgagg tggaggtgca   3840
 ggtttgccat taagagccat ctgcaagggc gtagtctggc ttgcaggagg caaaggagca   3900
 gtcttcaact tctttgtact agttttagac ggatgctcct cctcctcttc atcagaatcc   3960
 tgaaggccat acttagaaaa atgggagacc ttaaacaccc aagaaccagt ttcaggccgg   4020
 tattctttga attcagctcc ctgtttcctt gaaactgctt ccaatcttcc ttcatagttg   4080
 atatcagcaa ggcgatctgg gctctttatt aaacaacgag atgttttatc tgttggccaa   4140
 actccatcca atgtaacttc agccttccta tttagccctt cacccacagg tggtttttgg   4200
 ttatcatcta agtagacaac tacttctttc ctccggatat gcacaatatc atccaaattt   4260
 agatttgtca aattcacatc tccttcaaaa tagattgaac cataaccttt ccgaccaata   4320
 gtgaaatcag agacaatgca ctctccaaaa acattggtaa ttttagcaag gtcatccata   4380
 gatggaatag tatagtaacc aaccttagtg agaataatac ctgctgggtg catatggtaa   4440
 gaattatttt ctatttcttc tcggtcatcc tgaagtgact catcatgaaa agacgtttct   4500
 tcactgcttc cttccagccc atttcgcaaa gcagcacgca tgtttaatgc aacaatggta   4560
 tcatccacac tgttgctgtt gctgtgttta tttccagcac tttctggggt ttgaggaata   4620
 ggtttggcaa tagggttagt ataaaaatgt gaaacaaggg aatcttcatc tccatcctgc   4680
 tggtgattct catcaacagg tttgcttagg aaactaaatc tctctccatt ttctggatat   4740
 tcagatggtg aagctagatt ttctgaatca cgattaacag gagaaaagag attgctatta   4800
 ttaaggttct tcaaaaccaa cttcttaatg ctcttcttgg gcatgaatgc tccattggct   4860
 agggatggtt catcgtcatc cagcccatca aagagatgtg acttggctgt gcctgttgtt   4920
 tgtaaagcct ttggccggac tctagtggca gggcggggtg tcagtttata atgagtaggt   4980
 gtagtaagag ccttctgggc tgctggattt gttggtttca atctctcttc cttcttctta   5040
 gggtctgaca tcggattccg gaagagagga gagtctccaa aaggtgagta tgttagacta   5100
 ttgatgtgct gctggagaac agcctgctgg gcagcagaag catttggatc tgtcaaagct   5160
 actggggcct ggggggctcc aaagcccaaa gtggctgtcg tagtattaaa tccaggggcc   5220
 ccaaaggctc ctgtaccaag aggccctcca atcttaggtt ggttgttccc aaacaaagat   5280
 gcctgtccag caccaagagc tgttccaaat cctgcaccaa gcccagttcc aagagtccca   5340
 ggtgctggtt tacttccaaa aatactattc ccactggtat ttgtgccaaa accaaagagc   5400
 ccgccactgg ttgtaccaaa tgaaggtgca ctggttgtgc tgcttccaaa tgtagtaagc   5460
 ttgttattgc caaacagggt cgaaccaaca gcaccaaatc cagtattggt ctgcccaaag   5520
 agacctgttc ctgttccaaa tgctgtccca gtgctggtgt ttgtagctgt cccaaaaaga   5580
 cctccaggct gtgaggcttg ggttactcca aataatccca tggtgttggt gcttggctgt   5640
 cctatggtgc tggtattacc aaaggaaaag ccagtgttct gggtggttgt agcctggcca   5700
 aatggtttgc tgaagaggct ggtagtctgc tgattctgtt ggccaaagag accacctgga   5760
 tttgttccaa atccagttgt actagttcca aaggcagttt tgttctgacc atatgcaaag   5820
 cctgaattag tggtggagga gctgaagagt cctgttgcgc tggaagtggc tggagaagac   5880
 ccaaacaagc cagttgtggt acctgctccc acctggttct gtgggccctt cctgttagcc   5940
 tgataatcct ctaaacgaag ttcctctagt gacttgcttt catattcttt catagcagta   6000
 atacactggt gcttggtact tatgttagtg ctaactccag ctttgaccat agtatctgta   6060
 ccagttggag ggttaaattt aatagtagtc ccagtaggag cagctgtaaa actacttggc   6120
 ccaaagaggg agccagatgt gctgccaaaa ggattagagg tggtatttgt ggttccaaag   6180
 agtcctccac tgctagtact ggttccaaaa ttgccaaagc cagttggttt attttgtgca   6240
 aaggcattgt tttgggatga gaagagactg gtccctgtgc ttgcagttcc aaacaaggta   6300
 tttgctgttc ctgttgacgt accaaaccca aagccagtgc ttgtggaggt agctggctgg   6360
 ctaaatgaac tggttccaaa caatcctcct ggtttagtct gtgaatttcc aaagaggcct   6420
 ccagtattgt tgctagaacc aaatgcagat gttccaaatg cccctccact agtagtgcca   6480
 aagccagtat tctgtccaaa tgttgaagtt gtgccaaagc cacctgtgcc acccccaaag   6540
 ggtgttccaa atgatttgtt aaacat                                        6566



      <210> 2268
      <211> 2830
      <212> DNA
      <213> Homo sapiens


      <400> 2268
 acaacccctt ctcctggaag aactttgtag acaccgtccg cgacaccacc gccgcgcacc     60
 aggctctgct ggtggccaag aacgtcgact cgtttccgca aaaccaggag cgcttcggcg    120
 ggggccacat cgacgtgtgg tggatcgtgc acgacggcgg catgctcatg ctgctgccct    180
 tcctgctgcg ccagcacaag gtgtggagga agtgccggat gcgtatcttc accgtggccc    240
 aggtggacga caacagcatc cagatgaaga aggacctgca gatgttcttg taccacttgc    300
 gcatcagcgc cgaggtggag gtggtggaga tggttgaaaa cgacatatct gctttcacct    360
 acgagaggac actaatgatg gagcagaggt cgcagatgct gaagcagatg cagctgtcca    420
 agaacgagca ggagcgagag gcccagctga tccacgacag gaacaccgcg tcccacaccg    480
 cggcggcagc caggacccaa gcgccgccta cgccagacaa ggtgcagatg acctggacca    540
 gggagaagct gatcgctgag aagtacagga gcagagacac cagcctatct ggtttcaaag    600
 acctcttcag catgaagccg gaccagtcca acgtcaggcg gatgcacacg gctgtgaagc    660
 tcaatggcgt cgtcctcaac aagtcccagg atgcgcagct ggtcctgctc aacatgccag    720
 gtcctcccaa aaaccggcag ggagacgaga actacatgga gtttcttgaa gtcctgaccg    780
 aggggctgaa cagagtcctc ctggtcaggg gtggcggccg ggaggtgatc accatctact    840
 cctaatgccc aacagcatca cggcactctg ggacaggcac ggaggacggc gtgggcagcc    900
 tgggcctggg cttggcccag ggaaacagac ggcagacaca cctgtccccc agtgatgcca    960
 cccaagctgc ccatggggct tcctacggaa gtttctaggc ccgtcaccta gggctctcct   1020
 gttcagcctt aacaggctca gcaaatcagg gcgtggctgg acgatttcct tgcatctgag   1080
 ggcagacgct gctaccggag tgacctggac gtggccagat cttctcgcag gtcacaagaa   1140
 gccagtgagc ccttgccttg gtttctggaa gttcttttcc ttggctggat ttacccagtg   1200
 gttaggttgc atttctaccc catccagaac attcttggaa gagcacccgg agctgaagct   1260
 gtccctgatg atgaaggtga aacgtcagcc ctggccatgg ctccgctcag ggccccggtc   1320
 acctccgagt cactctgttc cttgactgtc tttgtgtttc tgtacctcaa ggcactgaag   1380
 ctggaggact ctgtccatgc ccgtgtcacc ctcgtgtggg agcctctggg ctcggcaggt   1440
 ccacatttca tgagctgagg cgtgggccag ggccatctgg aaagggaact cggcttttcc   1500
 agaacgtggt ggatcatctg tcgggtgtgt ggtgaacacg ttcagttcat cagggcctac   1560
 gctccgggaa ggggccccca gctgtggctc tgccatgccg ggctgtgttt gcagctgtcc   1620
 gagtctccat ccacctttag aaaaccagcc acttcttttc ataagcactg acagggccca   1680
 gcccacagcc acaggtgcga tcagtgcctc acgcaggcaa atgcactgaa acccaggggc   1740
 acacgcgcgc agagtgaaca gtgagttccc ccgacagccc acgacagcca ggactgccct   1800
 ccccacccca ccccacccca ggagcacggc acacagttca gcctctgagc tggctcacac   1860
 gtgccatccc caccccggtg ctccagggaa ggaggacacg gacccgacgt gggaggtcct   1920
 caggcagcag tggcgcctgg tgtcaggtct gtctggctga gtcccgggcg tcccctgcca   1980
 tggcctgtgc cttgcatgga ggcggcggtg gcactgaaga gatagctttc aagggcccaa   2040
 cactttgcac ttcggctggc tgtgagtttc tgctttgtag gttgtggtca catttgcagg   2100
 ctgcgggcag tggcaccgac ttgggcctcc ctttctatgt ggcatattta tttatttaaa   2160
 caccccaggg agttacgtgg taacaaggtt gtccataaag aggttgcttc tatatactag   2220
 aggccccaga tggccaggcc ttgggctacg tctggcttgc atggtctccc aagggaatca   2280
 gccccatcaa caaagttcaa atcggggcag aggctgcact tgtgccccca gatgtttctg   2340
 aggagccaga ctagggctgg cattgctgta gagtgacggc tgctgcccag agcgtgtccc   2400
 agacatcaca gcggggctca gcagttccca cagcctctgc ctgccttggc taagcatgag   2460
 ttaagcagca aaacgctcct ccatgtctgg atggggccgg caggtcctgt gtcccctgca   2520
 cctggaggag agcaggctag aggcacagcg gccacatggt gctggctctg aacgttggtt   2580
 ggtggctgga aaacagccct gcttctgagg gccgctcagt tctgcacacg aaaccacctc   2640
 ctgagggctc agctctgccc ccgccctggg ctgcagcctc tgcacgcaag caccaggcat   2700
 cctttgtgtt gtcaactccg tgtaaccagt aactacagcc atttacaatt gactccgttt   2760
 ccttttgtag gtttccctgt ctgtctgtgt tagtagaaaa ataaaatcct atgaaatctg   2820
 aaaaaaaaaa                                                          2830



      <210> 2269
      <211> 1659
      <212> DNA
      <213> Homo sapiens


      <400> 2269
 atgggagact ttaacacccc actgtcaaca ttagacagat caacgagaca gaaagtcaac     60
 aaggataccc aggaattgaa ctcagctctg caccaagcgg acctaataga catctacaga    120
 agtctccacg ccaaatcaac agaatataca tttttttcag caccacacca cacctattcc    180
 aaaattgacc acatacttgg aagtaaagct ctcctcagca aatgtaaaag aacagagatt    240
 ataacaaact atctctcaga ccacagtgca atcaaactag aactcagaat taagaatctc    300
 actcaaaacc gctcaactac atggaaactg aacaacctgc tcctgaatga ctactggata    360
 catgacgaaa tgaaggcaga aataaagatg ttctttgaaa ccaacgagaa caaagacaca    420
 acataccaga atctctggga tgcattcaaa gcaaccgcta gcaagactaa taaagaaaaa    480
 gagaagaatc aaatagacac aataaaaaat gataaagggg atatcaccac cgatcccaca    540
 gaaatacaaa ctaccatcag agaatactac aaacacctct atgcaaataa actagaaaat    600
 ctagaagaaa tggataaatt cctcgacaca tacactctcc caagactaaa ccaggaagaa    660
 gttgaatctc tgaatagacc aataacagga gctgaaattg tggcaataat caatagttta    720
 ccaaccaaaa agagtccagg accagatgga ttcacagccg aattctacca gaggtacaag    780
 gaggaactgc atataaacag agccaaagac aaaaaccaca tgattatctc aatagatgca    840
 gaaaaggcct ttgacaaaat tcaacaaccc ttcatgctaa aaactctcaa taaattaggt    900
 attgatggga cgtatttcaa aataataaga gctatctatg acaaacccac agccaatatc    960
 atactaaatg ggcaaaaact ggaagcattc cctttgaaaa ctggcacaag acagggatgc   1020
 cctctctcac cactcctatt caacatagtg ttggaagttc tggccagggc aattaggcag   1080
 gagaaggaaa taaagggtat tcaattagga aaagaggaag tcaaattgtc cctgttcgca   1140
 gacgacatga ctgtatatct agaaaacccc attgtctcag cccaaaatct ccttaagctg   1200
 ataagcaact tcagcaaagt ctcaggatac aaaatcaacg tgcaaaaatc acaagcattc   1260
 ttatacacca acaacagaca aacagagagc caaatcatga gtgaactccc attcacaatt   1320
 gcttcaaaga gaataaaata cctaggaatc caacttacaa gggatgtgaa ggacctcttc   1380
 aaggagaact acaaaccact gctcaaggaa ataaaagagg atacaaacaa atggaagaac   1440
 attccatgct catgggtagg aagaatcaat atcatgaaaa tggccatact gcccaaggta   1500
 atttacagat tcaatgccat ccccataaag ctaccaatga ctttcttcac agaattggaa   1560
 aaaactactt taaagttcat atggaaccaa aaaaagagcc cgcatcgcca aggcaatcct   1620
 aagccaaaag aacgaagctg gaggcatcac actacctga                          1659



      <210> 2270
      <211> 4686
      <212> DNA
      <213> Homo sapiens


      <400> 2270
 gtggactgtg cattgtcact tattcgactt gggatggagc ggaatattcc tggtttgctg     60
 gttctctgtg acaatttggt tactctggaa acattggttt atgaagccag gtgtgatgta    120
 actctaaccc tgaaagaact ccagcagatg aaagacattg aaaaactaag attactgatg    180
 aatagttgtt ctgaggataa atatgtgaca agtgcctacc agtggatggt tccctttctt    240
 catcgttgtg agaaacagtc gcctggtgtg gctaatgagc tattaaaaga atatttagta    300
 actttagcta aaggggactt aaaatttccc ctgaagatat ttcagcattc caaaccagat    360
 ctgcagcaaa aaattattcc tgatcaggac caactgatgg caatagcact agagtgcatc    420
 tatacctgtg aacgaaatga tcaactctgt ctttgctatg acctactaga atgtctgcca    480
 gaaagaggat atggtgataa gacagaggca accacaaagc ttcatgacat ggtagaccaa    540
 ctggaacaaa ttctcagtgt gtcagagctt ttggaaaaac atggactcga gaaaccaatt    600
 tcatttgtta aaaacactca atctagctca gaagaggcac gcaagctgat ggttagattg    660
 acgaggcaca ctggccggaa gcagcctcct gtcagtgagt ctcattggag aacgttgctg    720
 caagacatgt taactatgca gcagaatgta tacacatgtc tagattctga tgcctgctat    780
 gagatattta cagaaagcct tctgtgctct agtcgccttg aaaacatcca cctggctgga    840
 cagatgatgc actgcagtgc ttgttcagaa aatcctccag ctggtatagc ccataaaggg    900
 aaaccccact acagggtcag ctacgaaaag agtattgact tggttttggc tgccagcaga    960
 gagtacttca attcttctac caacctcact gatagctgca tggatctagc caggtgctgc   1020
 ttacaactga taacagacag accccctgcc attcaagagg agctagatct tatccaagcc   1080
 gttggatgtc ttgaagaatt tggggtagag atcctgcctt tgcaagtgcg attgtgccct   1140
 gatcggatca gtctcatcaa ggagtgtatt tcccagtccc ccacatgcta taaacaatcc   1200
 accaagcttc tgggccttgc tgagctgctg agggttgcag gtgagaaccc agaagaaagg   1260
 cggggacagg ttctaatcct tttagtggag caggcacttc gcttccatga ctacaaagca   1320
 gccagtatgc attgtcagga gctgatggcc acaggttatc ctaaaagttg ggatgtttgt   1380
 agccagttag gacaatcaga aggttaccag gacttggcca ctcgtcaaga gctcatggct   1440
 tttgctttga cacattgccc tcctagcagc attgaacttc ttttggcagc tagcagctct   1500
 ctgcagacag aaattcttta tcaaagagtg aatttccaga tccatcatga aggaggggaa   1560
 aatatcagtg cttcaccatt aactagtaaa gcagtacaag aggatgaagt aggtgttcca   1620
 ggtagcaatt cagctgacct attgcgctgg accactgcta ccaccatgaa agtcctttcc   1680
 aacaccacaa ccaccaccaa agcggtgctg caggccgtca gtgatgggca gtggtggaag   1740
 aagtctttaa cttaccttcg acccccttca ggggcaaaaa tgtggtggtg catatcaaat   1800
 cggaactaca gccaatgaag atctagagaa acaagggtgt catccttttt atgaatctgt   1860
 catctcaaat ccttttgtcg ctgagtctga agggacctat gacacctatc agcatgttcc   1920
 agtggaaagc tttgcagaag tatttgctga gaactggaaa attggcagag gctaaaaata   1980
 aaggagaagt atttccaaca actgaagttc tcttgcaact agcaagtgaa gccttgccaa   2040
 atgacatgac cttggctctt gcttaccttc ttgccttacc acaagtgtta gatgctaacc   2100
 ggtgctttga aaagcagtcc ccctctgcat tatctctcca gctggcagcg tattactata   2160
 gcctccagat ctatgcccga ttggccccat gtttcaggga caagtgccat cctctttaca   2220
 gggctgatcc caaagaacta atcaagatgg tcaccaggca tgtgactcga catgagcacg   2280
 aagcctggcc tgaagacctt atttcactga ccaagcagtt acactgctac aatgaacgtc   2340
 tcctggattt cactcaggcg cagatccttc agggccttcg gaagggtgtg gacgtgcagc   2400
 ggtttactgc agatgaccag tataaaaggg aaactatcct tggtctggca gaaactctag   2460
 aggaaagcgt ctacagcatt gctatttctc tggcacaacg ttacagtgtc tcccgctggg   2520
 aagtttttat gacccatttg gagttcctct tcacggacag tggtttgtcc acactagaaa   2580
 ttgaaaatag agcccaagac cttcatctct ttgagacttt gaagactgat ccagaagcct   2640
 ttcaccagca catggtcaag tatatttacc ctactattgg tggctttgat cacgaaaggc   2700
 tgcagtatta tttcactctt ctggaaaact gtggctgtgc agatttgggg aactgtgcca   2760
 ttaaaccaga aacccacatt cgactgctga agaagtttaa ggttgttgca tcaggtctta   2820
 attacaaaaa gctgacagat gaaaacatga gtcctcttga agcattggag ccagttcttt   2880
 caagtcaaaa tatcttgtct atttccaaac ttgttcccaa aatccctgaa aaggatggac   2940
 agatgctttc cccaagctct ctgtacacca tctggttaca gaagttgttc tggactggag   3000
 accctcatct cattaaacaa gtcccaggct cttcaccgga gtggcttcat gcctatgatg   3060
 tctgcatgaa gtactttgat cgtctccacc caggtgacct catcactgtg gtagatgcag   3120
 ttacattttc tccaaaagct gtgaccaagc tgtctgtgga agcccgtaaa gagatgacta   3180
 gaaaggctat taagacagtc aaacatttta ttgagaagcc aaggaaaaga aactcagaag   3240
 acgaagctca agaagctaag gattctaaag ttacctatgc agatactttg aatcatctgg   3300
 agaaatcact tgcccacctg gaaaccctga gccacagctt catcctttct ctgaagaata   3360
 gtgagcagga aacactgcaa aaatacagtc acctctatga tctgtcccga tcagaaaaag   3420
 agaaacttca tgatgaagct gtggctattt gtttagatgg tcagcctcta gcaatgattc   3480
 agcagctgct agaggtggca gttggccctc ttgacatctc acccaaggat atagtgcaga   3540
 gtgcaatcat gaaaataatt tctgcattga gtggtggcag tgctgacctt ggtgggccaa   3600
 gggacccact gaaggtcctg gaaggtgttg ttgcagcagt ccacgccagt gtggacaagg   3660
 gtgaggagct ggtttcacct gaggacctgc tggagtggct gcggcctttc tgtgctgatg   3720
 acgcctggcc ggtgcggccc cgcattcacg tgctgcagat tttggggcaa tcatttcacc   3780
 tgactgagga ggacagcaag ctcctcgtgt tctttagaac tgaagccatt ctcaaagcct   3840
 cctggcccca gagacaggta gacatagctg acattgagaa tgaagagaac cgctactgtc   3900
 tattcatgga actcctggaa tctagtcacc acgaggctga atttcagcac ttggttttac   3960
 ttttgcaagc ttggccacct atgaaaagtg aatatgtcat aaccaataat ccatgggtga   4020
 gactagctac agtgatgcta accagatgta cgatggagaa caaggaagga ttggggaatg   4080
 aagttttgaa aatgtgtcgc tctttgtata acaccaagca gatgctgcct gcagagggtg   4140
 tgaaggagct gtgtctgctg ctgcttaacc agtccctcct gcttccatct ctgaaacttc   4200
 tcctcgagag ccgagatgag catctgcacg agatggcact ggagcaaatc acggcagtca   4260
 ctacggtgaa tgattccaat tgtgaccaag aacttctttc cctgctcctg gatgccaagc   4320
 tgctggtgaa gtgtgtctcc actcccttct atccacgtat tgttgaccac ctcttggcta   4380
 gcctccagca agggcgctgg gatgcagagg agctgggcag acacctgcgg gaggccggcc   4440
 atgaagccga agccgggtct ctccttctgg ccgtgagggg gactcaccag gccttcagaa   4500
 ccttcagtac agccctccgc gcagcacagc actgggtgtg agggccacct gtggccctgc   4560
 tccttagcag aaaaagcatc tggagttgaa tgctgttccc agaagcaaca tgtgtatctg   4620
 ccgattgttc tccatggttc caacaaattg caaataaaac tgtatggaaa cgatgaaaaa   4680
 aaaaaa                                                              4686



      <210> 2271
      <211> 1467
      <212> DNA
      <213> Homo sapiens


      <400> 2271
 atggggtttc gccatgttgg ccaggctggt cttgaactcc tgacctcagg tctagggctg     60
 gtaacagctt caggttattg cactatttct tggggttccc catgcacctg tgcctttggg    120
 aatggtccca tagacggtca ctcgctgagc atcatcttag aaatggggct gtgcactatg    180
 aagactaaac aagagttcca ggactggacc aaaagaagtg tggaacttga gggtgggaat    240
 gcctcatcag aacttcaaag cttccaaggc catcacaaca aggagggtct gagaaactgt    300
 cgcagccagg aggagcccga ggagatgctc ccgaccatca tgtggaatcc tggacgggat    360
 ccagtagaag actcagaaag tggtgtttac atgcgattca tgaggtcaca caagtgttat    420
 gacatcgttc caaccagttc aaagcttgtt gtctttgata ctacattaca agttaaaaag    480
 gccttctttg ctttggtagc caacggtgtc cgagcagcgc cactgtggga gagtaaaaaa    540
 caaagttttg tagagcttta tttacaagaa acatttaagc ctttagtgaa tatatctcca    600
 gatgcaagcc tcttcgatgc tgtatactcc ttgatcaaaa ataaaatcca cagattgccc    660
 gttattgacc ctatcagtgg gaatgcactt tatatactta cccacaaaag aatcctcaag    720
 ttcctccagc tttttatgtc tgatatgcca aagcctgcct tcatgaagca gaacctggat    780
 gagcttggaa taggaacgta ccacaacatt gccttcatac atccagacac tcccatcatc    840
 aaagccttga acatatttgt ggaaagacga atatcagctc tgcctgttgt ggatgagtca    900
 ggaaaagttg tagatattta ttccaaattt gatgtaatta atcttgctgc tgagaaaaca    960
 tacaataacc tagatatcac ggtgacccag gcccttcagc accgttcaca gtattttgaa   1020
 ggtgttgtga agtgcaataa gctggaaata ctggagacca tcgtggacag aatagtaaga   1080
 gctgaggtcc atcggctggt ggtggtaaat gaagcagata gtattgtggg tattatttcc   1140
 ctgtcggaca ttctgcaagc cctgatcctc acaccagcag ccccagtcaa atatgaacaa   1200
 cccagccttt gtcagggcca catggacccg atgtgggagc aaacagcatg ccctttgaac   1260
 tctcagaatc caatattaaa cgaattcact ggtatggaac aggtgatgtg gcataaggtg   1320
 agtgcacggt atgttcagat cacagtgcct tatgtccgaa tacagcaata tgtcaccgcc   1380
 gcagccgggg cgcacgcgtg tgaaacaaca ccgagcttga atgtggaagt ctttgaacct   1440
 tttaccaaat cagtttgttt tctttag                                       1467



      <210> 2272
      <211> 588
      <212> DNA
      <213> Homo sapiens


      <400> 2272
 aaattctact cccgattggg ccaacaccgc cccgcggcgc actgttatat accaacatat     60
 tccttttaat gtaatatatg agaaaaaatg ttcggcggcc tattcacctt actgaacata    120
 tgagaattca tactggggag aaacctttca gatgtaagga atgtggaagg gcctttattc    180
 aaagtgcatc cctcagtaca caccagagaa tccatactgg tgagaaaccc tttgaatgtg    240
 aggaatgtgg gaaagccttc agacatcgct catcacttaa tcagcatcat agaactcaca    300
 ctggggagaa accctatgta tgtgataaat gtcagaaagc tttcagccag aacattagct    360
 tggttcaaca tttgaggact cattctggag agaaaccttt tacttgcaat gaatgtggga    420
 aaacctttag acagattaga caccttagtg aacatataag aattcatacc ggggagaagc    480
 cctatgcatg cactgcatgt tgtaaaacct ttagtcatag agcgtatcta acacatcacc    540
 agagaatcca tactggggag agaccctaca aatgtaaaga atggggag                 588



      <210> 2273
      <211> 972
      <212> DNA
      <213> Homo sapiens


      <400> 2273
 tcgcccacgc gtccgcccac gcgtccgcag cattcgggcc gagatgtctc gctccgtggc     60
 cttagctgtg ctcgcgctac tctctctttc tggcctggag gctatccagc gtactccaaa    120
 gattcaggtt tactcacgtc atccagcaga gaatggaaag tcaaatttcc tgaattgcta    180
 tgtgtctggg tttcatccat ccgacattga agtttgactt actgaagaat ggagagagaa    240
 ttgaaaaagt ggagcattca gacttgtctt tcagcaagga ctgggctttc tatctcttgt    300
 actacactga attcaccccc cactgaaaaa agatgagtat gcctgccgtt gtgaaccatt    360
 gtgactttgt cacagcccaa gatatgttaa gtgggatcga gacatgtaag cagcatgatg    420
 gagggtttga agatgccgca tttggattgg atgaattcca aattctggct tgcttgcttt    480
 ttaatattga tatgcttata cacttacact ttatgcacaa aatgtagggt tataataatg    540
 gtaacatgga catgagcttc tttataattc tactttgagt gctgtctcca tgtttgatgt    600
 atctgagcag gttgctccac aggtagctct aggagggctg gcaacttata ggtggggagc    660
 agagaattct cttatccaac atcaacatct tggtcagatt tgaactcttc aatctcttgc    720
 actcaaagct tgttaagata gttaagcgtg cataagttaa cttccaactt acatactctg    780
 cttagaattt gggggaaaat ttagaaaata taattgacag gattattgga aatttgttat    840
 aatgaatgaa acattttgtc atataagatt catatttact tcttatacat ttgataaagt    900
 aaggcatggt tgtggttaat ctggtttatt tttgttccac aagttaaata aatcataaaa    960
 cttgaaaaaa aa                                                        972



      <210> 2274
      <211> 1203
      <212> DNA
      <213> Homo sapiens


      <400> 2274
 tttttttttt tctgttttcc tgttgttttt aattaaagtc gcagctctct agaggagcac     60
 tgtccaccta gggaggaaag taggaggcca gtagcaaacc cctcccagag ctggggacat    120
 gtattcccct ggggaacccg gtggcatccg ccctgaggag cgcaccaccc cgcccagatc    180
 caggtcccgt cagggtgcca cctgctgcat gggcctgagg ttcggggaca cagcaaaggc    240
 acaccccgtg ctctttttga ttgtcgtcca cccgtaggcc ctcccagagc tccctcagcg    300
 tcagctcttt cttcctgtgc acgtcaaaca cgggcttctc ggtgatgatg cggtccacgc    360
 accgttttcc cggtcagcgg catggtgcat ttctccatga tctttggggg tgttgtcctt    420
 tgtgcagtgc tgcatggtga ccaccactct ggtcttctga ctggacacca agtccatggc    480
 accgcccatg cctttcacct tcttgccagg gatcatccag ttcgccaggt cgccgtattt    540
 ggaaacctgc atggctccaa gcatggttag ttggatgtgt ccccctcgga tcatggcgaa    600
 ggagtcgtcg ctggcgaaga agcagccccc gggaagcacc gtgaccgtct gcttgcctgc    660
 attgatgagg tcggcatcca cctcatcttc cgtgggaaac gggcccaggc ccaggatccc    720
 gttctcactg tgaagatgga cagtcatgct gggactgatg aagttgctgg ccagcagggg    780
 gatgcctatg cccagattgg cgtacatgcc gtcctcaaat tccagagctg cgcgtctgat    840
 gatgcgcgtc ctggcgtcct cttcctttcc agcgtctcca tcttcctctt tccggatcgt    900
 taagcgctca attcgtttct cgtatttctg cccctttatc acgcgaccta cataaatgtt    960
 aggaacgtgg atgtcttctg gggggaagcc cccacctcca ccgccgtgac gtctgcagct   1020
 ttgcacatgg gcacgttgaa attgcgggcg cttctcctga agaccacgtt tcctgcccgg   1080
 tcggccttcc accctttcac cagggcgaag tctgcccgga tggcgcgctc caaaaggaag   1140
 tggtcgccgt tgaactccct cacctctcgg ggctggctca tgagcgccag gtggccgtcc   1200
 ggg                                                                 1203



      <210> 2275
      <211> 1101
      <212> DNA
      <213> Homo sapiens


      <400> 2275
 gcggccgctc cctgccctgc agctttgggc tagggacctg ccgcttgcgc cggttcctac     60
 gagcggcgcc aagcgcccca ctctcccagt gtgggcagtg gcaccagtct ctgcagtaca    120
 tgcgaacggc tggtacgagg ccctggccgc gtcttcgccg gtgcgggttg cggaggaagt    180
 actgctcggc gtgcacgccg ccacgggcct gccctggtgg ggcagcattc tgctctccac    240
 cgtggcctta cggggtgctg tcacgctgcc tttggcagcc taccagcact acatcctggc    300
 caagctaggt ggaaaatttg cagccagaaa taaaaactat tgccaggcat cttaaccaag    360
 aagttgcagt tcgtgcaaat cagttggggt ggtccaaaag agatgccagg ctcacttatc    420
 taaagaatat gaggaggcta atttcagagc tatatgtgcg agataactgc caccctttca    480
 aagccactgt gttggtttgg attcagcttc caatgtggat cttcatgtct tttgctctcc    540
 ggaatttaag cacgggggca gcacattcag aaggtttttc tgttcaggaa cagttagcta    600
 ctggtggaat tctgtggttt cctgacctca ctgcacccga ctccacttgg attctgccta    660
 tctctgttgg cgtcatcaat ttgttaatag tggagatttg tgctctacaa aaaattggaa    720
 tgtctcgttt tcagacgtat attacgtact ttgtccgtgc aatgtcggtg ttgatgatac    780
 caattgctgc aacggtaccc tcatcaattg ttctctactg gttatgctcc agcttcgtgg    840
 gcctttcaca gaatttgctg ctgcgttctc ctggatttcg ccaactttgc cgaataccat    900
 cgaccaagtc agattcagaa actccttata aagacatatt tgctgccttt aataccaagt    960
 tcatttcaag aaaatgacat attttccata attttgaaac agttgcagga gtcactatca   1020
 tctaaatgta tttagactta gaaattcaga tgttacttga tttcctttta tttaaaatca   1080
 ttaacttcat gaaatacgaa a                                             1101



      <210> 2276
      <211> 539
      <212> DNA
      <213> Homo sapiens


      <400> 2276
 atgcgcgctg acgtaagatt gtagccagta gagtcgtcgc actacacggc gtgtgtgtgt     60
 ctcttactta tatccccaac ccgtttcgtc caggacgatg gctgcaacca ggacagcccc    120
 agcaatggag tcaatgatga tgttggtgcc gctgggacct ttatatctct ccgtctcccc    180
 cgtgggtggg gacgtgggca gggggttatg gatactgcag tctttgcctg tccagtctgg    240
 ctgacagatg cacttccctt cattgctgca gacctatagg cagggcaggg ccaggagagg    300
 tgagcagggg cctgtcccct cttgtaagct tctcccgcca tcccaggctc caggcagtca    360
 ccccgtggtg ggagcaaatc cggcgctccc cactgtcggt gcaggtgctg aagttgaagg    420
 ccaaagctgg caagcagaga tggtccaggg acaacatggt aggtccgcag gctgtgccat    480
 cctccacata agtcagggca gagccgtccc ccacctggac gtgggctcct ctgcaggcg     539



      <210> 2277
      <211> 2710
      <212> DNA
      <213> Homo sapiens


      <400> 2277
 atgaagcgtg cgcctgttat tccaaaacat acgctcaata ctcaaccggt tgaagatact     60
 tcgttatcga caccagctgc cccgatggtg gattcgttaa ttgcgcgcgt aggagtaatg    120
 gctcgcggta atgccattac tttgcctgta tgtggtcggg atgtgaagtt tactcttgaa    180
 gtgctccggg gtgatagtgt tgagaagacc tctcgggtat ggtcaggtaa tgaacgtgac    240
 caggagctgc ttactgagga cgcactggat gatctcatcc cttcttttct actgactggt    300
 caacagacac cggcgttcgg tcgaagagta tctggtgtca tagaaattgc cgatgggagt    360
 cgccgtcgta aagctgctgc acttaccgaa agtgattatc gtgttctggt tggcgagctg    420
 gatgatgagc agatggctgc attatccaga ttgggtaacg attatcgccc aacaagtgct    480
 tatgaacgtg gtcagcgtta tgcaagccga ttgcagaatg aatttgctgg aaatatttct    540
 gcgctggctg atgcggattt tgccgatttc ggaaccacca tcaaacagga ttttcgcctg    600
 ctggggcaaa ccagcgtgga ccgcttgctg caactctctc agggccaggc gggttttaca    660
 gacagccctc attacagtga tcacttgaat gacagtcgat taggagccca tgaaggcttg    720
 tccccaacac ctttcatgaa ctcaaatctg atggtggact cttgttccaa actggaacaa    780
 cactcaaccc tatctcgggc tattcttttg atttataagg gattttgccg atttcggaac    840
 caccatcaaa caggattttc gcctgctggg gcaaaccagc gtggaccgct tgctgcaact    900
 ctctcagggc caggcggtga agggcaatca gctgttgccc gtctcactgg tgaaaagaaa    960
 aaccaccctg gcgcccaata cgcaaaccgc ctctccccgc gcgttggccg attcattaat   1020
 gcagctggca cgacaggttt cccgactgga aagcgggcag tgagcgcaac gcaattaatt   1080
 caggcaccgt gtatgaaatc taacaatgcg ctcatcgtca tcctcgggca ccgtcacctg   1140
 ggatgtggta ggcataggct tggttatgcc ggtacgccgg gccttcttgc gggatatcgt   1200
 ccattccgac agcatcgcca gtcactatgg cgtgctgcta gcgctatatg cgttgatgca   1260
 atttctatgc gcacccgttc tcggagcact gtccgaccgc tttggccgcc gcccagtcct   1320
 gctcgcttcg ctacttggag ccactatcga ctacgcgatc atggcgacca cacccgtcct   1380
 gtggatctac ccactattga ctgtcagctg tccttgctcc aggatgctgt ttttgacaac   1440
 ggatgtttta ttgcctttga tgttcattaa gaagcttggc gcaaatgttg cctttttatc   1500
 ctcgaagcaa gcctctgttt gtcatgtagc ttgtgataac cccactgttg cctttggctt   1560
 gcggcactgc gaagtgagaa aacacaaagc cattgttcaa aatctggaaa gtccagaaaa   1620
 cggtggttcg gaaagtggca cttactcatc tccccccctg gagacaaccg tgcccccccc   1680
 tgccccaggg ctcccccggg cccctggcca gggcttcttt gttgttcacc ggctggggta   1740
 tgggccaggt ctttgtaagc agaaacacac tccctcccta atgtcggtgg agccagaaca   1800
 attttgccta cacctggttt caaaggctct cgacggagag tacaagttgc agcgcctcaa   1860
 acgctcggaa ttgaactgga ccctctggca aaagaacaaa aaccattttg ttcactttgc   1920
 cattcctgtg tacctggtat tccaggatct ggctctcaac gggctacgtg ctttgctcgt   1980
 gcaaggtaac gacccccagg gatcagcctc aatgtatcac ggatgggtac cagattttca   2040
 tattcatgca gaagacactc tcctgccttt ctatcctggg gaaaaggacg atgtcactta   2100
 tgcaataaag cccacttgct ggcccgggct tgacattatt ccttcctgtc tggctctgca   2160
 ccgtattgaa actgagttac tgggcaaatt tgatgaaggt aaactgccca cccatccaca   2220
 cctgatgctc cgactggcca ttgaaactgt tgctcatgac tatgatgtca tagttattga   2280
 cagcgcgcct aacctgggta tcggcacgat taatgtctcc ttagaagaag tgtgtgacct   2340
 gctgcacgcg gctcctttcc agaacatctt gccgcgagtc catgtgaaag tgaaaaactg   2400
 gacaggacgt atggatcagc tgttttcaga ctcggacctt ttgctgaggg gacggaagca   2460
 agtgagggat tttgccgatt tcggaaccac catcaaacag gattttcgcc tgctggggca   2520
 aaccagcgtg gaccgcttgc tgcaactctc tcagggccag gcggtgaagg gcaatcagct   2580
 gttgcccgtc tcactggtga aaagaaaaac caccctggcg cccaatacgc aaaccgcctc   2640
 tccccgcgcg ttggccgatt cattaatgca gctggcacga caggtttccc gactggaaag   2700
 cgggcagtga                                                          2710



      <210> 2278
      <211> 1768
      <212> DNA
      <213> Homo sapiens


      <400> 2278
 tttttttttt ttgctaaatt caatatttat ctgaaagtta aagaaaagca aacaaacata     60
 tacaaaggac atttcatttt taatcactca aaaatgaaaa aggtttggac aatgtcaaat    120
 tccactcacc ataatgctat agttatacat taaatataat tactatctat acatatgcaa    180
 aaatataaag ttctatttca tacaataaaa ccctttatag aaaccatttt aaaattaagc    240
 agaacttctc aacattaata tgtgaggtga ggtctaagtc cttctaaagg tttctttaaa    300
 ggtttttaaa caaaatgcta aacctaaaaa cattgtcctg tcagttccca aattaaatct    360
 acttagaaca aaaacaaaaa tttatagctc ggtcacatac tacttaaata atattgttca    420
 ggcatctcta aaatcctcca tgttttcaag tatggaaata gaactcaaat attccacaat    480
 acagtactaa acagatggag tatttaggaa agactttgtt gtcatatggc acaatattaa    540
 tattttgttg cttcaatacg ttttgaaata aatatcagat ttttgttttt ttttcctaaa    600
 agaccaaaat tataatctac attaagataa ttctgactgt ggttaagact taagagtgta    660
 aaatacaaca tcaatatttt atcacaaaag taaagctggt aacaaattat aaaaggagcc    720
 agtactctac tgagacaggc tcggagatta aagctcatca tgatagaaat agtcatcatg    780
 gagctgtctg ccataatctg tggcttcact ggtgagaaac aagtccgggt tttccagaat    840
 ctcttcttca gagagctttt tgtcaccatt caaatccatt tcatcaatta gatgaagcgc    900
 ctcctgcttg tgcaatgccc tgattattag gtactaccca aggtaacagc tcttggggat    960
 caagcctgcc atcgttatct ttgtcataat cattcacgaa tctgtctttc tcaacaagta   1020
 tccattctgg atcttcattt gcagttggat cccacctgta atcaccaaga aattcttcca   1080
 aactaacaaa tccatcacca tttttgtcat gttcttctaa agcttcttga atgacaaatt   1140
 ccgtcatata atcaacttct tcaggatgct caaaagcaat aaattcttca agactcaaac   1200
 cgggacctga atcctggtta gctttttcaa atcgcttctt gtcctttaag tgaagcttcc   1260
 taaaggactc ctcttctgca tcatccagag cagtgttctc atcaaagtca atcacacgat   1320
 catacatctg aatgttatat tcatcccaag tcacagtatc atcactgttt ttatcatatt   1380
 caacaaactg ttgttttgct tcttgcatag cataatgctt aaaagacatc tgaatccatg   1440
 aactgagttc actttcagtg agaaagccat ctgagtccaa gtcgattttc tttatgatcg   1500
 cctgcagtct tttttgctgc tcttcgtggc cgagtttaac atattcatcc acatcttcct   1560
 ggacgcccag cagcgcctcg cggtcgtagt cgctgcggcg ctcgcccagc gggtagtgca   1620
 gctcctcggc cttgccggcg ccggccgcgg cggcgcacag cagcagcagc cccaacgccg   1680
 cggtcctcgg gcccagccgc atcgcgccgg cccgcggagg acaccgaggg acgcgaggag   1740
 ggaggctggc gggggcccgg gcggctgc                                      1768



      <210> 2279
      <211> 2049
      <212> DNA
      <213> Homo sapiens


      <400> 2279
 tttttttttt ttggtgagtt tcaatatttt attaaaatag catatttaac catggttaac     60
 caagaatatg ttaactttgt gccccccaac ctgcccccgc cccagatacg cagcaaaaca    120
 cagtagtgat ttcaaatatc cttgatcatg accaacagga atatttcaaa gtcaagtttg    180
 caactcaaaa gtagaccttg gaaaaacttt gaattaaaag agaaacataa agctctcaca    240
 cagaattctt ttatctgccc taaaatcaat gccggcgcac caccacctga caatactgct    300
 aggatttttc tttatgcata gtataacgac tcatttatta agtacccact tttataaata    360
 aaatcggcat tttttgtccc gcttaatgtt ccttttcagc ttcacaaaga aaccagtaaa    420
 taaaactgtc aacgacagtc acaacatatg ctctcacagc aagataaaaa aacttgaaaa    480
 tacgcagaga tgcatctacg ctattttaca taaaaagaga gattcaaaaa gtgcaaggca    540
 aaatctgcag ttttttgagg ggagctttta ggcacatcca tttcattaaa gcaagcttca    600
 gaatgaaatt ccagtttgtt cttcatgaca cctgttaaag tctttcttta aacgacaaca    660
 aaaaaaagcc aaaaatacat cccatcaagt gtacaatggt agtcttgtgt cctaaaagtg    720
 aggagttcag ctgtggcgag tccgtccttt ctttattctg gcaggctttg gtttggggat    780
 gtactgatta tttgcctggt actcgagttc tttacggaag tagtgaattg ctttgtttaa    840
 accttcctcc agcgggacca cgggctccca ccccagcatc agctttgctt ttttgatgtc    900
 tggttttctt ttctgtgggt catcctgggc ttcggagaga aactgaattt cacttccgct    960
 accaacaagg tttttaatta actgagcaaa ttctaggatt gtgtgttctt ctgggttccc   1020
 caggttgacc gggctgctga cgttgctgtt catgagagcc acgaggccat tcactagatc   1080
 gctgacgtac tggaacgccc ttgtctgaga cccggatccg tataccgtga gtggctcccc   1140
 ctggagcgcc tgcaggatga agttgctgac tactcgccca tcgttcatgt gcatgcgtgg   1200
 cccaaaggtg ttgaagattc tggccactcg cacttccacg ccttcctgct tcatgtaggc   1260
 atagcacatg gtctctgcaa cacgtttgcc ttcatcgtag caggcccgag gtcctattgg   1320
 attcacgtgg ccccagtaat cctcactttg agggtggact tcaggatctc catacacctc   1380
 cgatgtggag gccaggagca gacgggcacc gactcgtttt gccagcccca acatgtttaa   1440
 tgtcccaatc gtattggtct ttaatgtctt gataggatta tacatgtagt ttggagggga   1500
 ggctggagat gccagatggt atatctggtc aacctcgatg tagaggggct ccaccacgtc   1560
 gtggttaatc aactcgaagt tctcatgtcc gatccagtgc tccacgtttc tcttcctgcc   1620
 cgtgaagaaa ttgtccacca cggtcacctc gtggccgtcc atcatgagtt tgtcagttag   1680
 atgggagccc acgaaccctg cgcctcctgt tatcaaaatt cttttccgat ccttttctga   1740
 taaaaacttt actggtgggt atttctgggt aaagcttttt tctaaatctc tgattttctc   1800
 tcttagtggt tcaaccatct cttcaatctt gctttcaatt tttagttcac cattttcctg   1860
 gatagacctg ttgagtagaa agctcatatt aacgaagttg ccccaaacag aggcgacgta   1920
 ggccagcaag gcgatgccca gcagcagctt catcctcctg cggttgacgg cagacacgag   1980
 gcgcagcagc gccttgctca ccatccccgg gagccgcgcg ggtccagggc cctgccgcgc   2040
 gggggcccg                                                           2049



      <210> 2280
      <211> 1855
      <212> DNA
      <213> Homo sapiens


      <400> 2280
 ccggctcggt gatgtgactc cccaccccca gccgggtgct ccgagccatg gccgacacca     60
 tcttcggcag cgggaatgat cagtgggttt gccccaatga ccggcagctt gcccttcgag    120
 ccaagctgca gacgggctgg tccgtgcaca cctaccagac ggagaagcag aggaggaagc    180
 agcacctcag cccggcggag gtggaggcca tcctgcaggt catccagagg gcagagcggc    240
 tcgacgtcct ggagcagcag agaatcgggc ggctggtgga gcggctggag accatgaggc    300
 ggaatgtgat ggggaacggc ctgtcccagt gtctgctctg cggggaggtg ctgggcttcc    360
 tgggcagctc gtcggtgttc tgcaaagact gcaggaagaa agtctgcacc aaatgtggga    420
 tcgaggcctc ccctggccag aagcggcccc tgtggctgtg taagatctgc agtgagcaaa    480
 gagaggtctg gaagaggtcg ggggcctggt tctacaaagg gctccccaag tatatcttgc    540
 ccctgaagac ccctggccga gctgatgacc cccacttccg acctttgccc acggaaccgg    600
 cagagcgaga gcccagaagc tctgagacca gccgcatcta cacgtgggcc cgaggaagag    660
 tggtttccag tgacagtgac agtgactcgg atcttagctc ctccagccta gaggacagac    720
 tcccatccac tggggtcagg gaccggaaag gcgacaaacc ctggaaggag tcaggtggca    780
 gcgtggaggc ccccaggatg gggttcaccc acccgccggg ccacctctct gggtgccaga    840
 gcagcctggc cagtggtgag acggggacag gctctgctga cccgccaggg ggaccccgcc    900
 ccgggctgac ccgaagggcc ccggtaaaag acacacctgg acgagccccc gctgctgacg    960
 cagctccagc aggcccctcc agctgcctgg gctgaggtgt ctggtgcctg gaacagactt   1020
 ccctgtggag gattcctgcc agaccctgcc cggctcctcc ctgaccggtc cttgtgccct   1080
 caccagacac cctgttggcc atgactcaac aaaccagtgt tgggagccgt ctgcctcccc   1140
 agctcagtgc ctttctgcac cccttctctc ctggggagct gtctgcatcc gccaccccct   1200
 ccaaccactg ccctcagccc ccgaccttat ttattaccct cccctcccac acccccaatc   1260
 tacctggtga tgattttaag tttgcgcgtg tcttgggttg ggctgggggg tttcccacat   1320
 gcagtgtcag aggggccgcc cggtggggct atctccgttg ctatattaat ggcaagacta   1380
 aatgaaacct agggcacggc ctccgaagct gcgtgtggcc ccttagaggt gagcatcaga   1440
 gccagagcag tgagggggag actcacccac cctctccctc tcccttcagc tctgggaggc   1500
 aggcgcagtg cccccctccc gtgggctggc ccaggaccgc gggtgaaacc tgggtctgtt   1560
 tagtttcttt ggtttttgta tgtttgtttg tttttgacac agtctcgctt tgttgcccag   1620
 gctggggtgc agtggcacga tcgcggctca ctgcaacctc cacctcccgg gctcaagcga   1680
 ttctctcacc tcagcctcct gagtaggtgg gattacagat gcccgccacc acacccagtt   1740
 aatttttgta tttttagaag agatggggtt tctccatgtt ggccaggctg gtcttgaact   1800
 cctggtctca agtgatccgc ccgcctcggc ctcccaaagt gctgggatta caggg        1855



      <210> 2281
      <211> 1969
      <212> DNA
      <213> Homo sapiens


      <400> 2281
 tgaaaagttt gccaaactgt cgttgatgtg ggagagaaaa cgtcagagtt caaggccaaa     60
 ggctacttag ctctggggct cacgtacagt ctgcaggcca ctgacgcttc tttgcgaggg    120
 atgcaggagg tcctacagag aaaggcgctt cttgcatttc agagggccca cagcctgtca    180
 cccacagatc accaagcagc tttctacctg gctctgcagc ttgccatctc cagacagatc    240
 ccagaggctc tggggtatgt ccgccaagct cttcagcttc aaggtgacga tgccaactcc    300
 ctgcacctcc ttgccctcct gctgtcagca cagaagcatt accatgacgc tctgaacatc    360
 atcgacatgg ccctgagtga atacccagaa aatttcatac tactgttttc caaagtgaag    420
 ttgcagtcac tctgccgagg cccggacgag gcactgctga cttgtaagca catgctgcag    480
 atatggaaat cctgctacaa cctcaccaac cccagtgatt ctggacgtgg gagcagcctc    540
 ttagatagaa ccattgctga cagacgacag cttaatacaa ttactttgcc agacttcagc    600
 gatcccgaga caggctccgt ccatgccaca tcggtagcag cctcaagagt ggagcaggca    660
 ctgtcggaag tggcttcgtc tctgcagagc agtgccccta agcagggccc gctgcacccc    720
 tggatgacgc tggcacagat ctggctccat gcagctgaag tctatatcgg catcgggaag    780
 cctgcagaag ccacagcctg tacccaagaa gctgccaacc tcttcccaat gttcccacaa    840
 tgtcctctac atgcgcggcc agattgctga gctccgggga agcatggacg aggcgcggcg    900
 ggggtatgaa gaggccttag ccatcagccc cacccacgtg aagagcatgc agcgactggc    960
 cctgatcctt caccagctag gccgctacag tctggcggag aagatcctcc gggacgcggt   1020
 gcaggtgaac tcgacagccc acgaggtctg gaacgggctg ggcgaggtcc tccaagctca   1080
 gggcaacgat gcggcggcta cggagtgctt cctgacagcc ttggagctgg aggccagcag   1140
 ccccgccgtg cccttcacca tcatcccccg cgtgctctga gcaggcgcct gccagcctca   1200
 cctgccgctc aggcctcaga ggccctgccg ggcaccaggg cttgtgccat cgccccaagg   1260
 ggatgaatct gccgcactga ggccagggac gagtgttcag tgggccacag tgaaccaacc   1320
 aaaccaaccc cgaatcatcg ctctcgccat gtgcgtttct cttgtttttt ttgccagccc   1380
 aatggtagtt tctgaaccta ttgacattgt tcaaaatgga tcatgtgcca tattttgtta   1440
 gttgacatct gagttttcag taaaatgatt atggaattaa tcagcaaatg tagaagaata   1500
 tattcaaagt taaaattcag tggcagcaca gattattttt atcagagctg taaagaaaac   1560
 aactgtcctt ttctccccac cacccctcct gccccacttt ggcccagaaa ccaaatgtga   1620
 acttcctgtc tcccacctca gcactagtcc atgccaggac accagctgac aatttcttgg   1680
 ttttactgtc aataattgta ccatgtgatc aattactgtc ctcacttaga acaaagcctg   1740
 agtccgagaa tatttatatt ttaccaatat atgcctgtta caagagaagg aaatatgagt   1800
 tatttaagtt taactttttt atgtgaattc agagtttatt tatcgaggga aatatgtaca   1860
 aagaagcttc aaatggaata tttaccgaca ttccttatac atgacagaca cttggctaca   1920
 tgggaagatg atgttaataa taaaatgatt tttaaatgga aaaaaaaaa               1969



      <210> 2282
      <211> 4879
      <212> DNA
      <213> Homo sapiens


      <400> 2282
 tttttttttt ttcctggtgc agccagattg ttctaacttt tgaacaaatg agcgtggtca     60
 gtaatgtaca ataactcttg agtctgttac tttggcctag ctaagcccat ctggccctcg    120
 ggcatcctgc aagatgacag acagaagagc aagggcacta tcagaaatgg aacaggctgc    180
 cccctactcc tcccagcctc taccagtaca cagagacaga ctggagatag agcattcgca    240
 gccagttggc atcttggttc ttttgtcttc tgaaaataaa aataagtgct tgtcttgtct    300
 ttggaggtca aagagaaccg cactaattta tttcctcgag gggggctttt ctgggaggga    360
 gaggatcctc agtcctgttg cccaaggttt cacgctgttt gggccacacg gcagggcttt    420
 tcttctggga tctggtctgc acgtccagag atgatggagg aattgcatca gcatcatatg    480
 cacagtgaaa gggtggctct tgtccagaga ggcccattcc cgggcctggc tacatggcct    540
 cagggcctgg cggcagtttg aagagtctgg ctgcagatag gagctttcct tatgtgtctc    600
 tcctctgtga tgcccggcct cctgaaggca agtgtgagac agagaaggca cttggctcaa    660
 gtgtgctgaa gcccgcggtg gagagggtgc cggcgtacat gggcagaccg atggaaatga    720
 gccaatctga cacagaccga aatgcaccca ggagagacgg gctttcggca gatttccgtg    780
 agtccaccac ttggaatcgc catgcggtgc tgcttccgaa gctgcttcac ccggatctgg    840
 tccatgttgg cggcgacgtc ccgctcgggc tgatccaagt cctctgcgta tctctgcacc    900
 agggcttcaa ggaaatccca cagcggccat gccttaatca agaatacggc tccctccgtg    960
 aagatcgaat gccttcagcg tgcaagcttg ttttcagtga gcgtttctag atccactccc   1020
 cgggcacagg agaccttccc tggtcaaagc cgggcccagc ttcacaccgt gctcctggag   1080
 gcttgtgttc tcggggagct ctgagagcca ggggggcggc cttgtgcttg gtgggctgcc   1140
 aagcgcctgc cctgagagag gcctgggagc cagtgctggg ggacagtcgc tagggctggt   1200
 ggggctggcg gggctgcccc ttttcactgg caggcatggc gcatcgggac tggggagggc   1260
 cccactgggg cccatgggaa cagggtggag tccgttagca aggcgttctc tgctcttttt   1320
 ggcaggaaca ggtggaggct gtgatggaat tttgggctgc attctctgct cagcatctac   1380
 cccttctttg gtgcccaggg gatggtgtgt tccttcaaac tcgtgtcctt ttctgtggcc   1440
 ctccagaggc gtccttgcta aaccgtgttt agctccagga ggctgagcat catagtttct   1500
 gggcaaacac tgagggggtg acaggccgcg accagaggct gcgattgagc cctccagttt   1560
 cttagttgtc aatttctgag gttcagaaaa tctcttgctt tgggtcagta gcaatgcatt   1620
 gtcgacagca gagtcttgct ccaggggctg ggccttcgtg gaagaggcgg tcgtcttctg   1680
 tggcacttca ggtacaatct gagggggcgg ttctgtcacc tcggtaggca cgtcttgctc   1740
 agcaccaggc tccacttgaa ggtcatccag ggaatgggat cggggccaag tgtccacagt   1800
 ctgggggccc tcccagggtc tcaacagctc cggcaagatg gaaaactggg aggcttcctt   1860
 cggtttttaa ttcaaaacca gtcaacaccc aggtgggtca cagctcttgg acgtgtcctg   1920
 gggcaaggcc accacccagc ctgccctcct cctgtccctg cttcagtgca tcccctgatt   1980
 tcattaaagg caatgttggg taattgccca actggtttct gctaaaagcc ttcaagctgg   2040
 gctcggtgga tgacttggca gataggaggc tagctttccg agtcttgccg ttttccaggt   2100
 tctcactgct ttcgtagcat catgagtctc ggggtgagca tccactcagg ccctggctgt   2160
 caacgagcag cttctcctgg gatcctgact ggtcgctgtt actgtcatac tcttgtaaca   2220
 gctccactgc tgtcaagaga tcagctctgt gctccgggtc cctgatattt aactcatcca   2280
 agtcttcctc ctccagcagc ttaaaggtgt ccaaatcttc atatccattg aacaggaaag   2340
 tgggcatgtg ctcttttagg ttaatccgat ccaggagatc ctccacagac ttgggctggg   2400
 gtggtcgtcc tttccgacgc ctcctggtgg ggcgtttggg tttctcctcc gtcttcactg   2460
 agcacgtcca cgtagatgaa attgaacgtg ccgactttgt tgttcagcag gcccatccag   2520
 gtccccatgg gtggcttgct gattatatcg atgatatctc ctttcttgag cttgagtgag   2580
 tctgtgtcat agggactggg ggtgaagtcg gtgtgcaccc tggcacgccc gcagaacggg   2640
 cctcggtaag gcggctcttc gtcatcccca tcttccgact tgacgctttc ccggttgctg   2700
 gttgaggaat cagtggtgct cactgtttga ccgctcatgg agctctgccc actgagagaa   2760
 ctgcgaagac tttctacaga acccccggcc ttgagcttgg gcttgtccaa gtgttcgggg   2820
 tcgggctgtg aaggcggagg ggagccaggc attccatcaa ggcccgagtc ctgctcagag   2880
 acagagctgc tgtatttttt agacattctc tttctcatcg tctctttcac tgatttcacc   2940
 tttttcccaa gagagatgcg agaggcagta ggtgatttga tgacttcttt gtacacaaag   3000
 tctccttctt tacccattgg gtcagaatta ttactgccaa cgtgcagaga gcgattcgtc   3060
 aagtcaaatc ctccaaaact gcaggttctc ccgtggctta gggacccgag acccttcttc   3120
 atctccccct cggtgaggga gcgggacact ttctgggcct tttcttcttc tgggtaggag   3180
 aagaatgtcc ccatcttctt ggggggctta atcaggcccc ggctctctcc tttgctgaag   3240
 gttttgacca acttccggcc agccccccag gtgtccaggc tgctggagga tggagacgtg   3300
 gtgagagagt ctgagtcatc ttcgggaggt ttctcaggag agccatcaaa gaaaaggggc   3360
 ttcttgtgca cgccagagta gagggcggac cgttcatcca ggaccggcga attctcaaac   3420
 acgtgctcct ccccaccttc agtgtctggg ttttttcatt tcttccaccc taattagttt   3480
 ctttctgact ctgcgagtgg agtttaccag cttgtgtaac ctcttaaact tcaccgactc   3540
 ctcagtctca tcatccgatt gttctcttga attgcagttt gatgagccat caaacgttgg   3600
 gtaagaacca tctggccagt cagcagggtc cagggcagcc gactgccggt gctgggcctc   3660
 gtattccttg agcctagcaa gtgcttcctc aattgtgatc atcttttctt tgaccatcat   3720
 cattagctga atccgctcct catcgctcat cgttatttca ctggcaacat aaccaacgtc   3780
 ttctcctttt gaagtctgtc tcattattcc tttctggttc tttcggaagt tctgccagaa   3840
 atacttattt ttcttcttcc agtctccttt tcctacagag ctgtcttctg agtttgattt   3900
 atgaagaggg ttctttcttt ccacttctgg ggttgacacg gcgctacaga agccaagcga   3960
 ctcttcgatc tgggaccgca gctgaagtga cgtggggcta gcatcgggtt tctccacttc   4020
 caggtcctgg gaaacccgcc gtttccgcag ctcctccatc ctctcgcaca cgtcggagaa   4080
 acaggtgttg taataatctg catactgctg cgccaggtca tcgatgtttc ccagtgaacc   4140
 gtccaggata cccatcacgt cggtccagag tcgggagaac gcctcggatg tgccagcacc   4200
 cggcttgggc tccggttccg gctccggcgc gggctcgggc tccggctcgg gctcgggctc   4260
 aggctccggc cccgggccag ctgctcccgc gtcctccatg gccgtgtccc gcgcgcgggc   4320
 cgtgcgtccc agtccccgcg gcgccctcgc cccgcacccg cgcgcagcct gcccggatgc   4380
 cgggtccccg cccgcggcgt caccgagccg cgcccccgcg ctgcatgccc cggcggcccc   4440
 ggccaccccg cgggggccct tcgcaggcgc ccgcacctcg ggtctaggtg gccacgggct   4500
 gcgcgactga caactccaga aactttccca ccccgctcgg cgcagcaaca gggtagcagg   4560
 aggcaaagtc cgcaccactg agttgtacgg cggggaattc gctcggccca gaagcaatta   4620
 aacccactgc aaaggcgttt cttcctgtga cgggaaccaa ctaactaagg cacgcgactc   4680
 gttccttcta gcaagtcttg gcaggacccg gcaggggtgg ccgcggagcc tctagatctt   4740
 ggagggagct ccccgggacc cctctcttca aaatgagctc ttccagctcc acatgactct   4800
 ctccctcgag gctaaagaaa gcgtttagca acaaaaggtg ctctgatgtc aggctctttg   4860
 catggaaatg agcctcgga                                                4879



      <210> 2283
      <211> 435
      <212> DNA
      <213> Homo sapiens


      <400> 2283
 gtcacaggag cggcggtggc gggcggatcc gagcacctct cggcctgacc ccagagccta     60
 gctctcaccc cggcgaggga cttccacccc gactcaccgc ggaatgggga gcgccaggct    120
 gaaccaaatc ctgtgctcac ccctccgtgc aaacccctca aggcaactca ggcctctgaa    180
 agccttccta cccccccgct ctccgctcag gtccccactc aaccggtgcc caccgccctg    240
 gcgcgcgtcg ctccgcgatt accggcccgc caaacagtcc ccgcaaagtc caccctccgg    300
 ggctcccggt ccctcaggtc ccgcgtgccc ggccctgggc atccgcagcg tccccgtggt    360
 atcggacccc catcgtccct gacacctggc gtctccgccc cccgcccccg acgaaatcgt    420
 cgacccggga attcc                                                     435



      <210> 2284
      <211> 4353
      <212> DNA
      <213> Homo sapiens


      <400> 2284
 gcgaaggacg gcaccaagga cgggctggag aggaccaggg cagccgtgaa gaggggccgc     60
 tccttcatca ggaccaagtc tctcatcgca caggatcaca gatcttctct tgaggaagaa    120
 cagaatttst tcattgatgt tgactgcaag cacccggaag ccatcttgac cccgatgccc    180
 gagggtttat ctcagcagca ggttgtaaga agatatatac tgggttcagt tgtcgacagt    240
 gaaaagaact acgtagatgc tcttaagagg attttggagc aatatgagaa gccgctgtct    300
 gagatggagc caaaggttct gagtgagagg aagctgaaga cggtgttcta ccgagtcaaa    360
 gagatcctgc agtgccactc gctatttcag atcgcgctgg ccagccgcgt ttccgagtgg    420
 gactccgtgg aaatgatagg cgatgtcttc gtggcttcgt tttctaagtc catggtgctg    480
 gatgcataca gtgaatatgt gaacaatttc agcacagccg tggcagtcct caagaaaaca    540
 tgtgccacaa agcccgcttt tcttgaattt ttaaagcagg aacaggaggc cagccccgat    600
 cgaaccacgc tctacagcct gatgatgaag cccrtccaga ggttcccaca gttcatcctc    660
 ctgctccagg acatgctgaa gaacacctcc aaaggccacc ccgacaggct gcctcttcag    720
 atggccctga cagagctcga aacactagca gagaagttaa atgaaagaaa gagagatgct    780
 gatcaacgct gtgaagtgaa rcaaatagcc aaagccataa acgaaagata cctgaacaag    840
 cttctcagca gtggaagccg atacctcatt cgatcagatg atatgataga aacagtttac    900
 aacgacagag gagagattgt taaaaccaaa gaacgccgag tcttcatgtt aaatgatgtg    960
 ttaatgtgtg ccaccgtcag ctcacgcccc tctcatgaca gccgtgtgat gagcagccag   1020
 aggtacttgc tgaagtggag cgttccactg ggacatgtgg acgccatcga gtayggcagc   1080
 agcgcaggca cgggcgagca cagcaggcac cttgccgttc acccgccgga gagcctggcc   1140
 gtggttgcta acgcgaaacc aaacaaagtt tacatggggc caggacaact gtatcaagat   1200
 ttacaaaact tgttgcatga cttaaatgta attggccaaa tcactcagct gataggaaac   1260
 cttaaaggaa actatcagaa cttaaaccag tcagtagccc atgactggac atcaggttta   1320
 caaaggctta ttttgaagaa agaagatgaa atcagagctg cggactgctg cagaattcag   1380
 ttacagcttc ccgggaagca ggacaaatct gggcgaccga cgttctttac agctgtgttc   1440
 aawacgttca cccctgccat caaggagtcc tgggtcaaca gcttacagat ggccaagctc   1500
 gccctagaag aggagaacca catgggctgg ttctgtgtgg aagacgatgg gaatcacatt   1560
 aaaaaggaga agcatcctct cctcgtcgga cacatgccyg tgatggtggc caagcagcag   1620
 gagttcaaga tcggaagttg cacccatcaa atgggtcaga ttgccatcgt ctcgtttcaa   1680
 aattccactc ccaaagtcat tgagtgcttc aacgtggaat ctcgcatcct gtgcatgctg   1740
 tacgttcccg tcgaggagaa gcgcagagag cctggggcac ccccggaccc cgagaccccg   1800
 gccgtgagag cttctgatgt ccccacgatc tgtgtaggga cggaggaggg aagcatttcc   1860
 atttataaaa gcagtcaagg ctccaagaaa gtgagacttc agcacttttt cactcctgag   1920
 aagtcctcag tcatgagcct ggcttgcacg tctcagagcc tgtacgctgg cctggtcaac   1980
 ggggcagtcg ccacctacgc cagagcccca gatggatcct gggattcaga gcctcaaaaa   2040
 gtgatcaagt taggcgtcct accagttaga agtctactca tgatggaaga cacgttgtgg   2100
 gcggcttccg gaggtcaagt cttcatcatc agtgtggaga ctcatgctgt agagggtcag   2160
 ctggaggccc accaggagga aggcatggtg atctcccaca tggccgtgtc cggcgtcggg   2220
 atctggattg ccttcacctc agggtccacg ctccgccttt ttcacacgga aactctcaag   2280
 cacctgcagg acatcaacat cgccacccct gttcacaaca tgctgccagg gcaccagcgg   2340
 ctgtcggtga cgagcctgct cgtctgccac ggattgctga tggtcggcac cagcctggga   2400
 gtcctcgtgg ccctgccggt cccacgtctg caagggattc ccaaagtgac cggaagaggc   2460
 atggtctcct accatgcaca caacagtcct gtcaaattca tcgtcctggc cacggctctg   2520
 cacgagaaag acaaggacaa atccagggac agcctggctc ctggccccga gcctcaggac   2580
 gaagaccaga aggacgcact tccgagtgga ggagctggtt catctctgag ccagggtgac   2640
 cctgacgcag ccatctggtt gggagattca ctgggatcga tgactcagaa aagcgacctg   2700
 tcctcctcat ctgggtccct gagcttgtct cacggctcca gctctctaga gcacagatca   2760
 gaggacagca ccatctatga tctcctgaag gatcctgtct cgctgagaag caaagcacgc   2820
 cgggccaaga aagccaaggc cagctcggcg ctggtggtct gtggagggca gggccaccgc   2880
 cgggtgcaca ggaaggcccg gcagccccac caggaagagc tggcgccgac cgtcatggtc   2940
 tggcagatcc ctctgctgaa tatataagca ggacggccgc cttctgctgt cagaatttgc   3000
 aatcaagggt gacttctcag ctaatcctac agcctgagtg gttaagctgt gtctacactg   3060
 gttgggaata aattaaaaac agtatttggg ggagaaacgt gcaatagcgt aatggtggtg   3120
 tccctgccaa ttccttcctt ctcttctgta cagcagaagt aattacaagc acttctcacg   3180
 aaggcagaag actgatgcaa ttttcgagta attgagtgca gttctgggaa aataccacat   3240
 tctttttgac tgctgtagtc catatatgaa tactaaatgt taaacttcat cagcgtcaga   3300
 cctattgtat catattagag aatttgcaga ctaagaattt atgagaaaat atatgtattc   3360
 ggtagtgcag gcatttatta acaattctta aaagttttac ctgattcaga ttcacgactt   3420
 ttatttatat tctatatttt tgaatttcag agtaaaattt gttaacaatt ttaaaagcca   3480
 ggtaacacct accagtccag ttagcatgat ttgctttcag aagtgagctg ggttttccaa   3540
 agtggtataa tgtgtgtact gtatatttta acaaagtaat atttttgtat tgcatttttc   3600
 tattaaaaaa ttaacagtta atgtttcagt caatgyatta tctgtagcat ttcacaaata   3660
 atgtttgctt tgaaccaaaa tgctcagtgc ctatcaacat ttggactcaa gcatcaacac   3720
 caaattattc ctcccttctc gtataaatag agtgactatc cacaggagaa aagtgtgtgc   3780
 tttagtatta gaggagatag gcagagaagt cttgcttagt tccttcgtgc agcttcttgc   3840
 ccctgttgac gtggaatgct gtgtctgctt tagcacgcac gctccgaatg actcctggtg   3900
 ctaggccatg ctggctgctg tcactgagcg ggactcaggc caagaggcgt gacctcgggc   3960
 cagcctgtct gttgtgcaga cgcctcctct gcagaacgca tcagtttcta ttctgcagtt   4020
 gcagagccag ccccgcgtga gaacgtgcat aatgagtgca caccatcatg tcaaggtgca   4080
 tacttagtga gcgccatcct gctgaacgtg tatttcagtg tttcacttac tggacggata   4140
 acaagaaaaa aatcctaaca caggcagtca ccagaaataa atgtctcagc actttacaga   4200
 tgactaaaaa tgttaatttt atgacttagc caaatatgtt ctaggttgca tatatccccc   4260
 atgtgaaagt gatttcttcc caagcttctc aaactgttag ctgctgtctg acttcatcaa   4320
 taaagtattt ttattttaaa atgyaaaaaa aaa                                4353



      <210> 2285
      <211> 4686
      <212> DNA
      <213> Homo sapiens


      <400> 2285
 gtggactgtg cattgtcact tattcgactt gggatggagc ggaatattcc tggtttgctg     60
 gttctctgtg acaatttggt tactctggaa acattggttt atgaagccag gtgtgatgta    120
 actctaaccc tgaaagaact ccagcagatg aaagacattg aaaaactaag attactgatg    180
 aatagttgtt ctgaggataa atatgtgaca agtgcctacc agtggatggt tccctttctt    240
 catcgttgtg agaaacagtc gcctggtgtg gctaatgagc tattaaaaga atatttagta    300
 actttagcta aaggggactt aaaatttccc ctgaagatat ttcagcattc caaaccagat    360
 ctgcagcaaa aaattattcc tgatcaggac caactgatgg caatagcact agagtgcatc    420
 tatacctgtg aacgaaatga tcaactctgt ctttgctatg acctactaga atgtctgcca    480
 gaaagaggat atggtgataa gacagaggca accacaaagc ttcatgacat ggtagaccaa    540
 ctggaacaaa ttctcagtgt gtcagagctt ttggaaaaac atggactcga gaaaccaatt    600
 tcatttgtta aaaacactca atctagctca gaagaggcac gcaagctgat ggttagattg    660
 acgaggcaca ctggccggaa gcagcctcct gtcagtgagt ctcattggag aacgttgctg    720
 caagacatgt taactatgca gcagaatgta tacacatgtc tagattctga tgcctgctat    780
 gagatattta cagaaagcct tctgtgctct agtcgccttg aaaacatcca cctggctgga    840
 cagatgatgc actgcagtgc ttgttcagaa aatcctccag ctggtatagc ccataaaggg    900
 aaaccccact acagggtcag ctacgaaaag agtattgact tggttttggc tgccagcaga    960
 gagtacttca attcttctac caacctcact gatagctgca tggatctagc caggtgctgc   1020
 ttacaactga taacagacag accccctgcc attcaagagg agctagatct tatccaagcc   1080
 gttggatgtc ttgaagaatt tggggtagag atcctgcctt tgcaagtgcg attgtgccct   1140
 gatcggatca gtctcatcaa ggagtgtatt tcccagtccc ccacatgcta taaacaatcc   1200
 accaagcttc tgggccttgc tgagctgctg agggttgcag gtgagaaccc agaagaaagg   1260
 cggggacagg ttctaatcct tttagtggag caggcacttc gcttccatga ctacaaagca   1320
 gccagtatgc attgtcagga gctgatggcc acaggttatc ctaaaagttg ggatgtttgt   1380
 agccagttag gacaatcaga aggttaccag gacttggcca ctcgtcaaga gctcatggct   1440
 tttgctttga cacattgccc tcctagcagc attgaacttc ttttggcagc tagcagctct   1500
 ctgcagacag aaattcttta tcaaagagtg aatttccaga tccatcatga aggaggggaa   1560
 aatatcagtg cttcaccatt aactagtaaa gcagtacaag aggatgaagt aggtgttcca   1620
 ggtagcaatt cagctgacct attgcgctgg accactgcta ccaccatgaa agtcctttcc   1680
 aacaccacaa ccaccaccaa agcggtgctg caggccgtca gtgatgggca gtggtggaag   1740
 aagtctttaa cttaccttcg acccccttca ggggcaaaaa tgtggtggtg catatcaaat   1800
 cggaactaca gccaatgaag atctagagaa acaagggtgt catccttttt atgaatctgt   1860
 catctcaaat ccttttgtcg ctgagtctga agggacctat gacacctatc agcatgttcc   1920
 agtggaaagc tttgcagaag tatttgctga gaactggaaa attggcagag gctaaaaata   1980
 aaggagaagt atttccaaca actgaagttc tcttgcaact agcaagtgaa gccttgccaa   2040
 atgacatgac cttggctctt gcttaccttc ttgccttacc acaagtgtta gatgctaacc   2100
 ggtgctttga aaagcagtcc ccctctgcat tatctctcca gctggcagcg tattactata   2160
 gcctccagat ctatgcccga ttggccccat gtttcaggga caagtgccat cctctttaca   2220
 gggctgatcc caaagaacta atcaagatgg tcaccaggca tgtgactcga catgagcacg   2280
 aagcctggcc tgaagacctt atttcactga ccaagcagtt acactgctac aatgaacgtc   2340
 tcctggattt cactcaggcg cagatccttc agggccttcg gaagggtgtg gacgtgcagc   2400
 ggtttactgc agatgaccag tataaaaggg aaactatcct tggtctggca gaaactctag   2460
 aggaaagcgt ctacagcatt gctatttctc tggcacaacg ttacagtgtc tcccgctggg   2520
 aagtttttat gacccatttg gagttcctct tcacggacag tggtttgtcc acactagaaa   2580
 ttgaaaatag agcccaagac cttcatctct ttgagacttt gaagactgat ccagaagcct   2640
 ttcaccagca catggtcaag tatatttacc ctactattgg tggctttgat cacgaaaggc   2700
 tgcagtatta tttcactctt ctggaaaact gtggctgtgc agatttgggg aactgtgcca   2760
 ttaaaccaga aacccacatt cgactgctga agaagtttaa ggttgttgca tcaggtctta   2820
 attacaaaaa gctgacagat gaaaacatga gtcctcttga agcattggag ccagttcttt   2880
 caagtcaaaa tatcttgtct atttccaaac ttgttcccaa aatccctgaa aaggatggac   2940
 agatgctttc cccaagctct ctgtacacca tctggttaca gaagttgttc tggactggag   3000
 accctcatct cattaaacaa gtcccaggct cttcaccgga gtggcttcat gcctatgatg   3060
 tctgcatgaa gtactttgat cgtctccacc caggtgacct catcactgtg gtagatgcag   3120
 ttacattttc tccaaaagct gtgaccaagc tgtctgtgga agcccgtaaa gagatgacta   3180
 gaaaggctat taagacagtc aaacatttta ttgagaagcc aaggaaaaga aactcagaag   3240
 acgaagctca agaagctaag gattctaaag ttacctatgc agatactttg aatcatctgg   3300
 agaaatcact tgcccacctg gaaaccctga gccacagctt catcctttct ctgaagaata   3360
 gtgagcagga aacactgcaa aaatacagtc acctctatga tctgtcccga tcagaaaaag   3420
 agaaacttca tgatgaagct gtggctattt gtttagatgg tcagcctcta gcaatgattc   3480
 agcagctgct agaggtggca gttggccctc ttgacatctc acccaaggat atagtgcaga   3540
 gtgcaatcat gaaaataatt tctgcattga gtggtggcag tgctgacctt ggtgggccaa   3600
 gggacccact gaaggtcctg gaaggtgttg ttgcagcagt ccacgccagt gtggacaagg   3660
 gtgaggagct ggtttcacct gaggacctgc tggagtggct gcggcctttc tgtgctgatg   3720
 acgcctggcc ggtgcggccc cgcattcacg tgctgcagat tttggggcaa tcatttcacc   3780
 tgactgagga ggacagcaag ctcctcgtgt tctttagaac tgaagccatt ctcaaagcct   3840
 cctggcccca gagacaggta gacatagctg acattgagaa tgaagagaac cgctactgtc   3900
 tattcatgga actcctggaa tctagtcacc acgaggctga atttcagcac ttggttttac   3960
 ttttgcaagc ttggccacct atgaaaagtg aatatgtcat aaccaataat ccatgggtga   4020
 gactagctac agtgatgcta accagatgta cgatggagaa caaggaagga ttggggaatg   4080
 aagttttgaa aatgtgtcgc tctttgtata acaccaagca gatgctgcct gcagagggtg   4140
 tgaaggagct gtgtctgctg ctgcttaacc agtccctcct gcttccatct ctgaaacttc   4200
 tcctcgagag ccgagatgag catctgcacg agatggcact ggagcaaatc acggcagtca   4260
 ctacggtgaa tgattccaat tgtgaccaag aacttctttc cctgctcctg gatgccaagc   4320
 tgctggtgaa gtgtgtctcc actcccttct atccacgtat tgttgaccac ctcttggcta   4380
 gcctccagca agggcgctgg gatgcagagg agctgggcag acacctgcgg gaggccggcc   4440
 atgaagccga agccgggtct ctccttctgg ccgtgagggg gactcaccag gccttcagaa   4500
 ccttcagtac agccctccgc gcagcacagc actgggtgtg agggccacct gtggccctgc   4560
 tccttagcag aaaaagcatc tggagttgaa tgctgttccc agaagcaaca tgtgtatctg   4620
 ccgattgttc tccatggttc caacaaattg caaataaaac tgtatggaaa cgatgaaaaa   4680
 aaaaaa                                                              4686



      <210> 2286
      <211> 649
      <212> DNA
      <213> Homo sapiens


      <400> 2286
 cattctgatg ttggagcggc cacagctgtc ttgcccctcc tcacggccgt gttgggtgtt     60
 accgtggtca cccgcaggga cacggagggg ccaggcagag cagccctagt tcacctcacc    120
 gggagccccc gccagaaggt gggcacctct gggagggagg gactgccagg ccttggggct    180
 tcctgtgctg agtcagagct ggaacgggag acgcaggagc cccgcagccg cgggaggtgc    240
 atatttgggg ctgccaggtg gcgccaggtc cccttggcca gcccccagcg cccctttctt    300
 ctgtccccag ggcctcggct tcacaggatg gggctgccag tgtcctgggc ccctcctgcc    360
 ctctgggttc tagggtgctg cgccctgctc ctctcgctgt gggcgctgtg cacagcctgc    420
 cgcaggcccg aggacgctgt agcccccagg aagagggcgc ggaggcagcg ggcgaggctg    480
 cagggcagtg cgacggcggc ggaagcggtg agtgccaagc tgtcccgggg accagggtgg    540
 ggtccgcagg ggaccgacca gccttcctcg cccccagtcc ctactgaagc ggacccacct    600
 ctgctccctc agcaagtcgg acaccagact gcacgagctg caccagggc                649



      <210> 2287
      <211> 5525
      <212> DNA
      <213> Homo sapiens


      <400> 2287
 tcgacccacg cgtacgcgga cgcgtgggat gacgggcccg gtgctgaagg gcagggaaca     60
 acttgatggt gctactttga actgcttttc ttttctcctt tttgcacaaa gagtctcatg    120
 tctgatattt agacatgatg agctttgtgc aaaaggggag ctggctactt ctcgctctgc    180
 ttcatcccac tattattttg gcacaacagg aagctgttga aggaggatgt tcccatcttg    240
 gtcagtccta tgcggataga gatgtctgga agccagaacc atgccaaata tgtgtctgtg    300
 actcaggatc cgttctctgc gatgacataa tatgtgacga tcaagaatta gactgcccca    360
 acccagaaat tccatttgga gaatgttgtg cagtttgccc acagcctcca actgctccta    420
 ctcgccctcc taatggtcaa ggacctcaag gccccaaggg agatccaggc cctcctggta    480
 ttcctgggag aaatggtgac cctggtattc caggacaacc agggtcccct ggttctcctg    540
 gcccccctgg aatctgtgaa tcacgcccta ctggtcctca gaactattct ccccagtatg    600
 attcatatga tgtcaagtcg ggcggagtag cagtaggagg actcgcaggc tatcctggac    660
 cagctggccc cccaggccct cccggtcccc ctggtacatc tggtcatcct ggttcccctg    720
 gatctccagg ataccaagga ccccctggtg aacctgggca agctggtcct tcaggccctc    780
 caggacctcc tggtgctata ggtccatctg gtcctgctgg aaaagatgga gaatcaggta    840
 gacccggacg acctggagag cgaggattgc ctggacctcc aggtatcaaa ggtccagctg    900
 ggatacctgg attccctggt atgaaaggac acagaggctt cgatggacga aatggagaaa    960
 agggtgaaac aggtgctcct ggattaaagg gtgaaaatgg tcttccaggc gaaaatggag   1020
 ctcctggacc catgggtcca agaggggctc ctggtgagcg aggacggcca ggacttcctg   1080
 gggctgcagg tgctcggggt aatgacggtg ctcgaggcag tgatggtcaa ccaggccctc   1140
 ctggtcctcc tggaactgcc ggattccctg gatcccctgg tgctaagggt gaagttggac   1200
 ctgcagggtc tcctggttca aatggtgccc ctggacaaag aggagaacct ggacctcagg   1260
 gacacgctgg tgctcaaggt cctcctggcc ctcctgggat taatggtagt cctggtggta   1320
 aaggcgaaat gggtcccgct ggcattcctg gagctcctgg actgatggga gcccggggtc   1380
 ctccaggacc agccggtgct aatggtgctc ctggactgcg aggtggtgca ggtgagcctg   1440
 gtaagaatgg tgccaaagga gagcccggac cacgtggtga acgcggtgag gctggtattc   1500
 caggtgttcc aggagctaaa ggcgaagatg gcaaggatgg atcacctgga gaacctggtg   1560
 caaatgggct tccaggagct gcaggagaaa ggggtgcccc tgggttccga ggacctgctg   1620
 gaccaaatgg catcccagga gaaaagggtc ctgctggaga gcgtggtgct ccaggccctg   1680
 cagggcccag aggagctgct ggagaacctg gcagagatgg cgtccctgga ggtccaggaa   1740
 tgaggggcat gcccggaagt ccaggaggac caggaagtga tgggaaacca gggcctcccg   1800
 gaagtcaagg agaaagtggt cgaccaggtc ctcctgggcc atctggtccc cgaggtcagc   1860
 ctggtgtcat gggcttcccc ggtcctaaag gaaatgatgg tgctcctggt aagaatggag   1920
 aacgaggtgg ccctggagga cctggccctc agggtcctcc tggaaagaat ggtgaaactg   1980
 gacctcaggg acccccaggg cctactgggc ctggtggtga caaaggagac acaggacccc   2040
 ctggtccaca aggattacaa ggcttgcctg gtacaggtgg tcctccagga gaaaatggaa   2100
 aacctgggga accaggtcca aagggtgatg ccggtgcacc tggagctcca ggaggcaagg   2160
 gtgatgctgg tgcccctggt gaacgtggac ctcctggatt ggcaggggcc ccaggactta   2220
 gaggtggagc tggtccccct ggtcccgaag gaggaaaggg tgctgctggt cctcctgggc   2280
 cacctggtgc tgctggtact cctggtctgc aaggaatgcc tggagaaaga ggaggtcttg   2340
 gaagtcctgg tccaaagggt gacaagggtg aaccaggcgg cccaggtgct gatggtgtcc   2400
 cagggaaaga tggcccaagg ggtcctactg gtcctattgg tcctcctggc ccagctggcc   2460
 agcctggaga taagggtgaa ggtggtgccc ccggacttcc aggtatagct ggacctcgtg   2520
 gtagccctgg tgagagaggt gaaactggcc ctccaggacc tgctggtttc cctggtgctc   2580
 ctggacagaa tggtgaacct ggtggtaaag gagaaagagg ggctccgggt gagaaaggtg   2640
 aaggaggccc tcctggagtt gcaggacccc ctggaggttc tggacctgct ggtcctcctg   2700
 gtccccaagg tgtcaaaggt gaacgtggca gtcctggtgg acctggtgct gctggcttcc   2760
 ctggtgctcg tggtcttcct ggtcctcctg gtagtaatgg taacccagga cccccaggtc   2820
 ccagcggttc tccaggcaag gatgggcccc caggtcctgc gggtaacact ggtgctcctg   2880
 gcagccctgg agtgtctgga ccaaaaggtg atgctggcca accaggagag aagggatcgc   2940
 ctggtgccca gggcccacca ggagctccag gcccacttgg gattgctggg atcactggag   3000
 cacggggtct tgcaggacca ccaggcatgc caggtcctag gggaagccct ggccctcagg   3060
 gtgtcaaggg tgaaagtggg aaaccaggag ctaacggtct cagtggagaa cgtggtcccc   3120
 ctggacccca gggtcttcct ggtctggctg gtacagctgg tgaacctgga agagatggaa   3180
 accctggatc agatggtctt ccaggccgag atggatctcc tggtggcaag ggtgatcgtg   3240
 gtgaaaatgg ctctcctggt gcccctggcg ctcctggtca tccaggccca cctggtcctg   3300
 tcggtccagc tggaaagagt ggtgacagag gagaaagtgg ccctgctggc cctgctggtg   3360
 ctcccggtcc tgctggttcc cgaggtgctc ctggtcctca aggcccacgt ggtgacaaag   3420
 gtgaaacagg tgaacgtgga gctgctggca tcaaaggaca tcgaggattc cctggtaatc   3480
 caggtgcccc aggttctcca ggccctgctg gtcagcaggg tgcaatcggc agtccaggac   3540
 ctgcaggccc cagaggacct gttggaccca gtggacctcc tggcaaagat ggaaccagtg   3600
 gacatccagg tcccattgga ccaccagggc ctcgaggtaa cagaggtgaa agaggatctg   3660
 agggctcccc aggccaccca gggcaaccag gccctcctgg acctcctggt gcccctggtc   3720
 cttgctgtgg tggtgttgga gccgctgcca ttgctgggat tggaggtgaa aaagctggcg   3780
 gttttgcccc gtattatgga gatgaaccaa tggatttcaa aatcaacacc gatgagatta   3840
 tgacttcact caagtctgtt aatggacaaa tagaaagcct cattagtcct gatggttctc   3900
 gtaaaaaccc cgctagaaac tgcagagacc tgaaattctg ccatcctgaa ctcaagagtg   3960
 gagaatactg ggttgaccct aaccaaggat gcaaattgga tgctatcaag gtattctgta   4020
 atatggaaac tggggaaaca tgcataagtg ccaatccttt gaatgttcca cggaaacact   4080
 ggtggacaga ttctagtgct gagaagaaac acgtttggtt tggagagtcc atggatggtg   4140
 gttttcagtt tagctacggc aatcctgaac ttcctgaaga tgtccttgat gtgcagctgg   4200
 cattccttcg acttctctcc agccgagctt cccagaacat cacatatcac tgcaaaaata   4260
 gcattgcata catggatcag gccagtggaa atgtaaagaa ggccctgaag ctgatggggt   4320
 caaatgaagg tgaattcaag gctgaaggaa atagcaaatt cacctacaca gttctggagg   4380
 atggttgcac gaaacacact ggggaatgga gcaaaacagt ctttgaatat cgaacacgca   4440
 aggctgtgag actacctatt gtagatattg caccctatga cattggtggt cctgatcaag   4500
 aatttggtgt ggacgttggc cctgtttgct ttttataaac caaactctat ctgaaatccc   4560
 aacaaaaaaa atttaactcc atatgtgttc ctcttgttct aatcttgtca accagtgcaa   4620
 gtgaccgaca aaattccagt tatttatttc caaaatgttt ggaaacagta taatttgaca   4680
 aagaaaaatg atacttctct ttttttgctg ttccaccaaa tacaattcaa atgctttttg   4740
 ttttattttt ttaccaattc caatttcaaa atgtctcaat ggtgctataa taaataaact   4800
 tcaacactct ttatgataac aacactgtgt tatattcttt gaatcctagc ccatctgcag   4860
 agcaatgact gtgctcacca gtaaaagata acctttcttt ctgaaatagt caaatacgaa   4920
 attagaaaag ccctccctat tttaactacc tcaactggtc agaaacacag attgtattct   4980
 atgagtccca gaagatgaaa aaaattttat acgttgataa aacttataaa tttcattgat   5040
 taatctcctg gaagattggt ttaaaaagaa aagtgtaatg caagaattta aagaaatatt   5100
 tttaaagcca caattatttt aatattggat atcaactgct tgtaaaggtg ctcctctttt   5160
 ttcttgtcat tgctggtcaa gattactaat atttgggaag gctttaaaga cgcatgttat   5220
 ggtgctaatg tactttcact tttaaactct agatcagaat tgttgacttg cattcagaac   5280
 ataaatgcac aaaatctgta catgtctccc atcagaaaga ttcattggca tgccacaggg   5340
 gattctcctc cttcatcctg taaaggtcaa caataaaaac caaattatgg ggctgctttt   5400
 gtcacactag gcatagggga tgtgttggaa atttaacttt gtaagcttgg tatgtggttg   5460
 ttgatccttt tttttcccta cagacacccc ataataaaat atcatattaa aattcaaaaa   5520
 aaaaa                                                               5525



      <210> 2288
      <211> 455
      <212> DNA
      <213> Homo sapiens


      <400> 2288
 cgagccgcgg gcttccagaa ctgtctcagc aaacagtagc tcctctcggc catccgccag     60
 ctgcagcagc tgctgaaggg ccaggagaca cgcttcgccg agggcatccg ccacatgaag    120
 agccggctgg ccgcgctgca gaactctgtg ggcagggtgg gcccagatgc ccttccagtt    180
 tcctgcccgg ctctgaacac ccccgcagac ggcagaaagt ttggaagcaa gtacttagtg    240
 gatcacgaag tccattttac ctgcaaccct gggttccggc tggtcgggcc cagcagcgtg    300
 gtgtgtcttc ccaatggcac ctggacaggg gagcagcccc actgtagagg tatcagtgaa    360
 tgctccagcc agccttgtca aaatggtggt acatgtgtag aaggagtcaa ccaagccaga    420
 tgcattttgc ctccacgaag gacttggaac cgtgc                               455



      <210> 2289
      <211> 3250
      <212> DNA
      <213> Homo sapiens


      <400> 2289
 cccacgcgtc cggtcaggac acagcatgga catgagggtc cccgctcagc tcctggggct     60
 cctgctactc tggctccgag gtgccaactg tgacatccag gtgactcagt ctccagactc    120
 cctgtctgca tctgtcggag acaaagtcac catcacctgc cgggcaagtc agggcattag    180
 caatgggtta tcctggtatc agcagaaacc agggcaagcc cctacgctcc tgatctatgc    240
 tgcatccagt ttgcagtcgg gggtcccatc tcggttcagt ggcagtggat ctgggacaga    300
 tttcactctc accatcagca gcctgcagcc tgaagatgtt gcaacttatt actgtctaca    360
 ggattatact accccattca cagtgttaca agccataaca aaaacccccc agagaagcag    420
 atgtgtgagt ctgcactgtc ctagctactc ctcctggtgt tatcaactgg ctgtagggag    480
 tgaatctaca gcctttaacg ataaaccaac aagtcacgcc aaagattcta tgcagatgac    540
 ttatttcgac aacttgcaat tcacttgcag tgtgtcttat acatctcaaa agaataaggt    600
 tacttcagat gacacaacat ttgaaatcta caacctgaat aaagatatgc gttctaagtt    660
 taaaactgta ggggctacag taatgcttag agcaggttat acaaccggat ttaaaagaga    720
 tgcaaatggt gatttggtca ttgaatatga caacttacca cttatctact taggcactat    780
 tgaatatgct tacacgtata aacgtggtgt agatatgatt acaaaagtaa tctgctcaaa    840
 tgacaaaatg gagagaacca ctatcaagac ctccatttca tataaagctg gtacatccag    900
 acagagtgtt atcagagact tggtaagcag attaggtttc acactcattg atgaagacct    960
 ttcaaatatc caaggttata cttacaagaa cggttttagt gtctggggaa gcaccgcaga   1020
 agcacttaca aaggtttgtg aagagagtgg actacgttgg tacaccttta acaaacaaat   1080
 ccgtgtagtg ccatttaacg ctaaagctaa acagctttct tgggaggttt tcccatataa   1140
 cgtgattgac tctctgcaag gctattatag aagaactcga aaggttctta aaaagcagaa   1200
 taagacagag attaaagtca aaactggtgt acgttgtaag attcacttag acggtcgtat   1260
 taagatggga gacaacgtta ctatcagaga aagtgaagac ttcgaaggtc agtaccgtgt   1320
 gaaagaatgt ctcgatgagt ttaaaaagga actgtacact ggtcttccag caattattgt   1380
 ttcttacgac tcaaaaacac aatccgcaac ggtaaggcca ttatattcta ttgatggtct   1440
 tccaatgcct gaaattacag gtgttcccgt tcaattccct agtggtggtg gagcatcttt   1500
 aacattccct gtaaaaacaa atgacagatg ctggttagca ttctctatgc tgccacttga   1560
 tgacttcgtt gtaaacgata aaaatgtaca gatggaaaca aatctgagaa gaactcatga   1620
 tatgtccgac tgtgtagcat ttgttggtat cggtacaaga acccagaact tcaacccaga   1680
 ccctacagca gtgagattac actacggaga ttccgtttta agaatcactg atgatgggaa   1740
 tttttatttt actggtgatg ttcatatctc caagaacctt tacgtaactg aagaagttca   1800
 cggttcagat tttatcagtg acacaacagg tagaacagct atctttgata actacatgaa   1860
 agcttacctt gttgaaacaa gagatgtaac aaacatctac aactactctt caacaatgga   1920
 taacgcactg agaaaagtaa ctgttaattt cgatgcgaca acatctactg atatcgtaac   1980
 agatattaca caagaggttg ctggagcttg gttgtggtgt aaatctccgc acaaactttt   2040
 aaattacttg ctcatgggtt cggaaagtca ggttcagaat gaagcaatca accttgcttg   2100
 tagaagggct tgtgaagagg gtcttacaaa gctgaatggt cgaaaaccag ctattggtgc   2160
 tagattgctt ttagcatacc acgatgagaa tagttgggag tgcccagaag agatgacaca   2220
 ggatgttaaa gcagtaattg actggatgta tggtcaggca tcaagaaact taggtcttaa   2280
 ggaggaaacg cttgtaactg gtactggtaa agttgagtta attcaggaga tgtccattgt   2340
 agtcatgcct agcaagttcg taaaaacctt taacaacgac gctttaaggt ctacacacat   2400
 ccttatcgtt gatgatgtcc aaactctcaa acaacaacat cttatagcta tggcaaaaat   2460
 ggtcaatcac atactacggt tattgagtga ggttttcacg atggaagtct tagtaaacta   2520
 tatctattgt tatgatgttg ttcactccac tacaaccgta gctcaacgta atcccatcat   2580
 cccacgagaa ggtgagttgg ttcgcattga tggttggact tacactgtgg aaagcatcat   2640
 tcataagttt gatgttgctg gcgatgttca agttatcgac gtagagattg gtggtgacaa   2700
 agttattaca acttatggta aagaaaatgg caagatgatg tttgaagagt atacagcaga   2760
 acctaaaaac atcggtaaaa agaatgagcg taatgctgaa cagcaagcta tctttgaagt   2820
 tactgctaag tacaagaagc aagttgaccg caaaggttat gcttacacaa aagagtctgc   2880
 acagaatact gagaaggtag gtgtacagct tgctcatgat gctgcaaagg ttagtcatgc   2940
 aaagtatctg aagttccctg ctgatgctca accaaaactg gatggtgtac gttgtagaat   3000
 ctcaagagat gctgatttag ttagcttcac ggcttattct cgtgagaata ctatttacaa   3060
 cgtcccagca gaactaatcc cagatttgct tttgttgctt aaattgcatc cacaagtcga   3120
 agactttgat ggtgagattt atgctcatgg ctgggactta gaagatattg tgtctatgat   3180
 taagaatgct gacaatccag accgacatct actccagttc tactgggttt tctgcagaga   3240
 aatccactga                                                          3250



      <210> 2290
      <211> 663
      <212> DNA
      <213> Homo sapiens


      <400> 2290
 gcggtggaat tcacctagga agcagtgcca aaatcaaatg caatagttgc caaagctacc     60
 atgagtctac taaacagctc acaatgaaaa aattacccat tgtggcttgt tttcatctca    120
 agcggtttga gcatgtaggc aaacagaggc gaaagattaa tacctttatc tcctttccct    180
 tggagctgga catgactccg tttttggcct ctactaaaga gagcagaatg aaagaaggcc    240
 agccaccaac agattgtgtg cccaatgaga ataagtattc cttgtttgca gtgattaatc    300
 accatggaac tttggaaagt ggccactata ccagcttcat ccggcaacaa aaggaccagt    360
 ggttcagctg tgatgatgcc atcatcacca aggctaccat tgaggactta ctctacagtg    420
 aagggtattt actgttctat cacaaacagg gtctagagaa agactagtct taccagacca    480
 cttactgaaa aaaaagtaaa tgattaggca aggattttga agtgacacac agacctactt    540
 ggaatggaca atgacagtaa cacctatgtg acagctagta tcttgatata aagaacctat    600
 tttagcatgg cccatgggtc tgtcggaaga aaaaaatgaa tactaaccag tgaccattca    660
 acc                                                                  663



      <210> 2291
      <211> 1169
      <212> DNA
      <213> Homo sapiens


      <400> 2291
 gactgccacc aactcctgtc cagctgctct atccagtgtc ccgattcagc aatgtcaaat     60
 ccctccagca cctttgcaga ttccggatac gacagctcgt caggatagat cacatcccag    120
 atctcccact gcctaagtac aatggggttg tcaggtttgg gacaggaatg agtaaggggg    180
 ttgtggggag acctctgatc tcttatatcc gaaagttcta ctactatgat cctcaggaag    240
 aggtatacct gtctctaaag gaagcgcagc tcatttccaa acagaagcaa gaggtggaac    300
 cctccacgcc cctgtctgtt gagggacacc ctggcagggg tgtagcagca gaagtagcag    360
 acgagaagct ggggtacatg ggcgatgggg cctgggagaa ggctgagtcc gaggagctgg    420
 aggtgcagaa gccccaggtg aagctgcgcc gggctgtgtc tgaggtggcc cgcccagcct    480
 ccacaccacc catcatggcc tcggccatca aggacgagga tgacgaggat cgcatcatcg    540
 cagagctaga ggtgtttgag agaagctcag tgtcttccct cccccccacg ccccgccgcc    600
 agctgatccc caccttgctg tccccccagg acctggggcc ccccgggggc tcagccccag    660
 gccctacacg gaagaggacc caacatcctc aagggcgccg gtttaacaaa ctggaaggga    720
 agaagaagag gagcaaagag gaaagttgta agcttacaca tgtgaagggg acaacgggca    780
 aaacccattc tgtccttttg ccatattatc tgggcctgga gtgcctacga cagctggccc    840
 aagcctcctg tctgcggggc aggactgctg gaaccattgt gaagacccag gctccggggg    900
 gcgcccctcc gcccagctcc ttccactcgt tgaagttgag gtcaggcagc gggctctgca    960
 ccaccacggt gtggcggcgc cagctgctcc ggcgccgccg ggtctcgggc gacagcggcc   1020
 gccgcaggcg cacggcgagc atggcggacg ccgcgacacc gagcaggaga cgcagcgcct   1080
 ccaaacgcga gggccgggag gccagcgccg ccgccggggg ccgcagcgac tcctggctgc   1140
 tggacgacgc cgagccgggc gcccattag                                     1169



      <210> 2292
      <211> 997
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> misc_feature
      <222> (1)...(997)
      <223> n = a,t,c or g


      <400> 2292
 ttttgtgaga cgaccacttt attaaatcac caggggttca aaacatttga aaagaaaact     60
 atgactggga aattactggt gtgtgtccga caccggggct ttgggtgggt taagggtttg    120
 ctttgaagct caccgagaac ttcaacatgg gcttttcccg gggcctcagg aggcaaatgg    180
 agctggggaa accccggagc cgaaggcggt tcactccccc gtcggggacg atggtgagcc    240
 tggcgtgagt gatgacatct tggagctcta gggtcaggct atcgaacaga tgactttggt    300
 tgggagacaa cttggtcact ggaagcagtg gtttccactt gtgggccggg agaatccact    360
 tttgcctgat cacggcttct tcctgagttg tcaggatgca cccatccact ttacagctgt    420
 caggagcatt gccttcaaaa tattttgtgt caatttcaat tcgagttatt actccaggat    480
 gtgccaatcg gaaaactgcc cattcacaac ccggaaccaa gagaatgcca ttctcatcat    540
 tttctaatat tggtggccgg tccagccttc ttgcagtttc ccaaccatcc gccatagact    600
 ttgccccgcc aactcctatt atattgtttg ggtgcccaaa cttagcatta ctaaatccta    660
 cacagacacc cccaaaagcg atggccacta ggtctgcagg ttctttgggg tcagttgcag    720
 tccagtcttt ttgtccagta ccgaatacta taagtcgtgc aattccacca tctgtgttgt    780
 tcacttctgt accactcttg tatcgtctct acctagaaga ggtctgggca catagtaggc    840
 attgaagttt ttttcattaa atgaacaact ccaaggtcaa acagcattcg ggaaattcac    900
 catacagata atgtttcgtg ctagaaataa gcatcgctga ctcccacaca gacgaattcc    960
 acggcatatg cgcngctaac tgggtnannn acccgcc                             997



      <210> 2293
      <211> 402
      <212> DNA
      <213> Homo sapiens


      <400> 2293
 atgtggccga gaggaaaagg tgtcaggtct cagggatgct gggagctccg gctctgcctg     60
 gctggcttca ttatagacca ggcagaaaca caagagcacc cgtccacagc ccgcagagaa    120
 aacctcagga aattctacaa gggcaagaag taccagcccg tggacctgca gcctaagaag    180
 acatgcgcca tgagccactg tctcaacaag cacgaggaga acctgaaggg caagaagcag    240
 cagtggaagg agtggctgtc cccgctgagg aaggaggaag gagcgcctgt ccctgctgag    300
 gaagggctgc ccggctgtcc tggcatccag cccagaaaag ctgcgctccc tgggaacggc    360
 ttggagcaga tgagcgctta cagcattgca ccatcctggt aa                       402



      <210> 2294
      <211> 1608
      <212> DNA
      <213> Homo sapiens


      <400> 2294
 gggttccgtg gccctgcacg tggagaagct gcccaatgag cccaaccgct tgcttatcct     60
 ccacggcttc ctggacgaaa acgtgcactt tttccacaca aacttcctcg tctcccaact    120
 gatccgagca gggaaacctt accagctcca ggtggccctg cctcctgtct ccccgcagat    180
 ctaccccaac gagagacaca gtattcgctg ccccgagtcg ggcgagcact atgaagtcac    240
 gttgctgcac tttctacagg aatacctctg agcctgccca ccgggagccg ccacatcaca    300
 gcacaagtgg ctgcagcctc cgcggggaac caggcgggag ggactgagtg gcccgcgggc    360
 cccagtgagg cactttgtcc cgcccagcgc tggccagccc cgaggagccg ctgccttcac    420
 cgccccgacg ccttttatcc ttttttaaac gctcttgggt tttatgtccg ctgcttcttg    480
 gttgccgaga cagagagatg gtggtctcgg gccagcccct cctctccccg ccttctggga    540
 ggaggaggtc acacgctgat gggcactgga gaggccagaa gagactcaga ggagcgggct    600
 gccttccgcc tggggctccc tgtgacctct cagtcccctg gcccggccag ccaccgtccc    660
 cagcacccaa gcatgcaatt gcctgtcccc cccggccagc ctcccccact tgatgtttgt    720
 gttttgtttg gggggatatt tttcataatt atttaaaaga caggccgggc gcggtggctc    780
 acgtctgtaa tcccagcact ttgggaggct gaggcgggcg gatcacctga ggttgggagt    840
 tcaagaccag cctggccaac atggggaaac cccgtctcta ctaaaaatac aaaaaattag    900
 ccgggtgtgg tggcgcgtgc ctataatccc agctactcgg gaggctgagg caggagaatc    960
 gcttgaaccc gggaggtgga ggttgcggtg agccaagatc gcaccattgc actccagcct   1020
 gggcaacaag agcgaaactc tgtctcaaaa taaataaaaa ataaaagaca gaaagcaagg   1080
 ggtgcctaaa tctagacttg gggtccacac cgggcagcgg ggttgcaacc cagcacctgg   1140
 taggctccat ttcttcccaa gcccgagcag agggtcatgc gggccccaca ggagaagcgg   1200
 ccagggcccg cggggggcac cacctgtgga cagccctcct gtccccaagc tttcaggcag   1260
 gcactgaaac gcaccgaact tccacgctct gctggtcagt ggcggctgtc ccctccccag   1320
 cccagccgcc cagccacatg tgtctgcctg acccgtacac accaggggtt ccggggttgg   1380
 gagctgaacc atccccacct cagggttata tttccctctc cccttccctc cccgccaaga   1440
 gctctgccag gggcgggcaa aaaaaaaagt aaaaagaaaa gaaaaaaaaa aaaaagaacc   1500
 aacccacctc tacatattat ggaaagaaaa tatttttgtc gattcttatt cttttataat   1560
 tatgcgtgga agaagtagac acattaaacg attccagttg gaaacatg                1608



      <210> 2295
      <211> 1857
      <212> DNA
      <213> Homo sapiens


      <400> 2295
 atggcgaaac ctaaatctta cttggtggct atgctgaaac ttgacccagg ccctggcttg     60
 caagtggacg tcagaactgc cccagatgct atcttaaata ttcagctgca agaattccaa    120
 ccaagttgga aagaaacttt atttcattat acttccaggt ctgggaatga tgccagtgaa    180
 cagctctcct tgacaggtct ctcatcactt acagctcaaa ggaaaagaga actcactcat    240
 ttcacccgtt tgatttgggt gaaatcatca actggggaca tcattaggag actaagacta    300
 gatgcctcta ggaaggcttt gcaggatggt tttgatctag ttattgaaga gactgattac    360
 tttttcatga gcaggtggtc caggtacctt gtggaggtaa aagagataaa ggtgctgtgg    420
 tatgatgatg gagccccatt tccaaatgga gaaacgaagg ctcaagacat tcagataaca    480
 tgtctccagt tgccatctag taaagtggga cactcaggat tcaaactcag gtgtccatct    540
 gtggagcacc ctgagcagca cgccccactg tggcctcaca gctccccaag caagcagctg    600
 gagcagggat tacactacat cagaaaagag tgcatcaggg atgcggggaa gaatataggg    660
 tctgatgagc aagacagaaa ccaacaaggt caagaacaca agcagactca gcttaccctg    720
 gcaagcaagg aagaagaaga agaaactaga gatgaaggca gtcaattcca gggaggtcat    780
 gttctgaagg gggtggacaa agcagagaag cttaaagggg gatccaagag gtggagggaa    840
 ggccccttcc ccgacagatc ttgcaatatt gacaaggcat cccaaactaa tgctatgaaa    900
 gaaaacattc gccttgataa cgtgtcccaa gaaaaactct ctgctggtgg ctccaactta    960
 gacaaaggaa caaagctgct ccaagcgtac ccccagaggg atgagggatg tttgtctttc   1020
 tccattcttg aagcaactat cattgcaatc ttcctcattt ccccaccttg ccaattgcct   1080
 tctgcacaca gccaagggac catgcagcag gcccctttag cgctgcggga atcccctgcc   1140
 tctatccgag atccacatta ccttgttgaa gtcttcagaa gttgccctca tttccttcca   1200
 tgtcttgttc aggagctgga tacagatgca gaaaaactcc tcaaaggatc tgtcgtgggt   1260
 gaagaacatc gggtggaagt cgttgcaggt ctcactagct ggaggaaaga gatggaaaat   1320
 aagagaaaaa gttttaaaac agtgaaacac gagaacataa ccacaggtat gtgccccaaa   1380
 gggagacaag cggaggcaca gatggctgga agtcaaagca acctgaatag ctttgaaggc   1440
 ggcaactggt ccagtcctgg gcaaaatcat aaaatcagcc aaaactgcct tcaagccccc   1500
 attgtagagc ttccttgggt cacacctagt gctcggaact ttaggtctgg tccctactct   1560
 cctcctcctc ctcctcctcc tcagcccctc ccatcatccc atctgtcaag cttacatttt   1620
 tatagccctt ttgtaagtta tacctcattt gatctttaca gttcctctta ccactcgtat   1680
 cttatggatg aggatactgt ggagcccaag gaactaaggt caagccaaaa agtgatcggc   1740
 cattctttta ctgggttcca gccaactctg tccgctaacc cctatgacag aggagatggg   1800
 aaaataattg agctgctacc taggaaggca caaacatttc ctgtggtgag gacttag      1857



      <210> 2296
      <211> 2986
      <212> DNA
      <213> Homo sapiens


      <400> 2296
 attgaccgcc tattagaccg cctgcagaat tcggacgagc ttgaaccggg gcattgctgc     60
 tgtcaaggag gatgcagtcg agatgctggc cagctacggg ctggcgtact ccctcatgaa    120
 gttcttcacg ggtcccatga gtgacttcaa aaatgtgggc ctggtgtttg tgaacagcaa    180
 gagagacagg accaaagccg tcctgtgtat ggtggtggca ggggccatcg ctgccgtctt    240
 tcacacactg atagcttata gtgatttagg atactacatt atcaataaac tgcaccatgt    300
 ggacgagtcg gtggggagca agacgagaag ggccttcctg tacctcgccg cctttccttt    360
 catggacgca atggcatgga cccatgctgg cattctctta aaacacaaat acagtttcct    420
 ggtgggatgt gcctcaatct cagatgtcat agctcaggtt gtttttgtag ccattttgct    480
 tcacagtcac ctggaatgcc gggagcccct gctcatcccg atcctctcct tgtacatggg    540
 cgcacttgtg cgctgcacca ccctgtgcct gggctactac aagaacattc acgacatcat    600
 ccctgacaga agtggcccgg agctgggggg agatgcaaca ataagaaaga tgctgagctt    660
 ctggtggcct ttggctctaa ttctggccac acagagaatc agtcggccta ttgtcaacct    720
 ctttgtttcc cgggaccttg gtggcagttc tgcagccaca gaggcagtgg cgattttgac    780
 agccacatac cctgtgggtc acatgccata cggctggttg acggaaatcc gtgctgtgta    840
 tcctgctttc gacaagaata accccagcaa caaactggtg agcacgagca acacagtcac    900
 ggcagcccac atcaagaagt tcaccttcgt ctgcatggct ctgtcactca cgctctgttt    960
 cgtgatgttt tggacaccca acgtgtctga gaaaatcttg atagacatca tcggagtgga   1020
 ctttgccttt gcagaactct gtgttgttcc tttgcggatc ttctccttct tcccagttcc   1080
 agtcacagtg agggcgcatc tcaccgggtg gctgatgaca ctgaagaaaa ccttcgtcct   1140
 tgcccccagc tctgtgctgc ggatcatcgt cctcatcgcc agcctcgtgg tcctacccta   1200
 cctgggggtg cacggtgcga ccctgggcgt gggctccctc ctggcgggct ttgtgggaga   1260
 atccaccatg gacgccatcg ctgcgtgcta tgtctaccgg aagcagaaaa agaagatgga   1320
 gaatgagtcg gccacggagg gggaagactc tgccatgaca gacatgcctc cgacagagga   1380
 ggtgacagac atcgtggaaa tgagagagga gaatgaataa ggcacgggac gccatgggca   1440
 ctgcagggac agtcagtcag gatgacactt cggcatcatc tcttccctct cccatcgtat   1500
 tttgttccct tttttttgtt ttgttttggt aatgaaagag gccttgattt aaaggtttcg   1560
 tgtcaattct ctagcatact gggtatgctc acactgacgg ggggacctag tgaatggtct   1620
 ttactgttgc tatgtaaaaa caaacgaaac aactgacttc atacccctgc ctcacgaaaa   1680
 cccaaaagac acagctgcct cacggttgac gttgtgtcct cctcccctgg acaatctcct   1740
 cttggaacca aaggactgca gctgtgccat cgcgcctcgg tcaccctgca cagcaggcca   1800
 cagactctcc tgtccccctt catcgctctt aagaatcaac aggttaaaac tcggcttcct   1860
 ttgatttgct tcccagtcac atggccgtac aaagagatgg agccccggtg gcctcttaaa   1920
 tttcccttcc gccacggagt tcgaaaccat ctactccaca catgcaggag gcgggtggca   1980
 cgctgcagcc cggagtcccc gttcacactg aggaacggag acctgtgacc acagcaggct   2040
 gacagatgga cagaatctcc cgtagaaagg tttggtttga aatgccccgg gggcagcaaa   2100
 ctgacatggt tgaatgatag catttcactc tgcgttctcc tagatctgag caagctgtca   2160
 gttctcaccc ccaccgtgta tatacatgag ctaacttttt taaattgtca caaaagcgca   2220
 tctccagatt ccagaccctg ccgcatgact tttcctgaag gcttgctttt ccctcgcctt   2280
 tcctgaaggt cgcattagag cgagtcacat ggagcatcct aactttgcat tttagttttt   2340
 acagtgaact gaagctttaa gtctcatcca gcattctaat gccaggttgc tgtagggtaa   2400
 cttttgaagt agatatatta cctggttctg ctatccttag tcataactct gcggtacagg   2460
 taattgagaa tgtactacgg tacttccctc ccacaccata cgataaagca agacatttta   2520
 taacgatacc agagtcacta tgtggtcctc cctgaaataa cgcattcgaa atccatgcag   2580
 tgcagtatat ttttctaagt tttggaaagc aggttttttc ctttaaaaaa attatagaca   2640
 cggttcacta aattgattta gtcagaattc ctagactgaa agaacctaaa caaaaaaata   2700
 ttttaaagat ataaatatat gctgtatatg ttatgtaatt tattttaggc tataatacat   2760
 ttcctatttt cgcattttca ataaaatgtc tctaatacaa tacggtgatt gcttgtgtgc   2820
 tcaacatacc tgcagttgaa acgtattgta tcaatgaaca ttgtacctta ttggcagcag   2880
 ttttataaag tccgtcattt gcatttgaat gtaaggctca gtaaatgaca gaactatttt   2940
 tcattatggg taactggggg aataaatggg gtcactggga gtaggg                  2986



      <210> 2297
      <211> 11519
      <212> DNA
      <213> Homo sapiens


      <400> 2297
 gaagttaaat agtgaatact ctttttattc agaagaatgc atttttaata gaatttcatg     60
 cgccagtaaa tcagtacagt gaggagttac aggggtgggg aacctctctt caggaaacat    120
 ctcaccctgg cagagctctc aactcccaga atccccttta cccagctcag gtgattagag    180
 accaaggaac agcagatggg gctgacttgc agggtaactg gttggattta taggtctctg    240
 agagcaagag agaggagagg aaagctcttg taaaggagga gattattata ttggaacggg    300
 cagttccaca gagattctct gagaggttga tgaaggagaa ttggcagggg tgcctggttc    360
 tccttcttgg ttacactctt caagggcaat ggtctggtct cttccgtctg tctctgagcc    420
 tctggttcgc agtcgaggcc acttcttcca ctctatggct agcactaccc ccaaggctac    480
 aacaaccacc acgattaggc tacttcggac aatgttccct acagtgcact cctgagcaac    540
 aggccctgct gcccccacca gctccagggg atcactaggc tctgaccaga tatcagggta    600
 ggcctggagg cggtagctgc agctgtagtt tccaatgcct tttccttcta cgttgttgat    660
 gacaaagtct ccatcctctg aaaactgctg aggtgcttct tctccatcat gttctagaac    720
 aaattcaaca cctggcaggg gtcctcggca ctgaagggtg atgtccttcc ctaacttgaa    780
 catggtgctg ggccaggctg acagagaggg tttagggggc ttatcagtca cccagatctc    840
 cagggagtca ctgtgatttg aagctgcaaa gggagtagag tccaaataat aaacacagct    900
 atagatccca gagtcttcac ctctcactgc tggcatccag aagtcagccc tgtacccact    960
 tggcctctgt tgctctaaag gctcctgagc cccctccttc aacaggacaa atgttgagtc   1020
 tggcagttcc ccttgacact gaagagtcat attttcgcca ggggccacca tgggaccagg   1080
 ctgggctaat aggctgggtt tggggagtaa gcctgtgact aggagttcca gggtgttgct   1140
 aggttgtatc ttgatagaac tggtccagtc agggtggtag cagcagctgt aacgccccat   1200
 gctagtacca gatatattgg tgatggggaa tgccccgtca ttactggtgg atccccagag   1260
 ctgcattgaa gtggcttctc cttctttgtg cagaatgtat cctactccat ggaccggccc   1320
 tcggcaccag agagtaacat tctgccccat gggaaccaca gaactgggct cagcaaacaa   1380
 ccatggctta gggaatgtgt cagtcaccca gatcataagg ggcatactga gatatgaccc   1440
 cctgtttgac atggttgtct catagtagat acagctatag ttcccagagt cctctgctcc   1500
 aacagtgtgg agaaggaagt cagctgagtt ccctgagaca ctccgaaact gtaagggaac   1560
 atgggctccc tcctgcaaga gggcgaacct catgccctgg aaagtccctt ggcagcgcag   1620
 gatcacactc ttcccaggaa acaccacagg acctggctgt gccaggagag tgggtttggg   1680
 gtagaattct gtcaccacga gctccacagg gtcgctgggc tcagaccaga tagaaaagtc   1740
 ataatatcgg cagctgtaat tccctccatc accaatgccc accgaaatga ttagaaagtg   1800
 agctgcactg gcccccggac ttgcccagga cctgtcactg gatgctattt cacttccatc   1860
 tttgtaaaga ataaagctca tatgctggtg gggggtggag caattgaaag tcactcgggc   1920
 accaggggtg accacagggc tggcccatgt cttgaagaag ggcttagggt acatttcttt   1980
 tatgacaagc tccagcggct cactgggctc agaccacttg aaggggcgtt tttcagtgtg   2040
 agtgcggcag ctgtaattgc cttcgtcttt atcctccatt ctctggattg taaagaaggc   2100
 ttctcttcca acagcaccaa gttgctggac aggttcttgc tctccctcct tatacagagc   2160
 aaaccccatg cctgccagcc atcctttgca ccggagttgt agttcctggc cccggattgt   2220
 gggggaagca gaaatgacag gtttggggag gatgtctgtc cccaccagct caagtgcctc   2280
 actgggctcc gatacagcca tctcctccca tgaatggcag tggtagctcc cggtgtggct   2340
 ctgggtcagg gcgccaaggg ggaaggcagc ccggacctgc tctgaggccg ggcgagtggc   2400
 gatccacccg gtcccatcct tcagcaacac aaactcctta gttgagccag aagggcttct   2460
 gcaccagagg gttaagttct tccacggggc cagaggaaag ttggtctctg cccacagctc   2520
 aggcttaggg gttggcatga ctatttcagt ctcttctatc aataccccat tgcacagtcc   2580
 acagcagaga agggccgtga ctatgaagag catggtgacc ccttgagctg ttcccagcaa   2640
 ccaggcttct ctgattctga gtctccgaca cttccacctt atccacagca ctaccaacag   2700
 caaggcaaca agctgcatga ttagagacaa cctgatagct tcattcagaa cgtaattcca   2760
 ggtgagatag cctgctggcc ccatcagctt caggggctca ctgcgatgtg accagatgtt   2820
 aggatgtgtc tctacgcgat agctgcaact gtaggtccct gtgcctttcc cgtcaacatt   2880
 actgatgatg aagtctccgt ttactgagaa tttttggaat gtttctcttt cttcccattc   2940
 cagagaaaac tccagtactg gatgagatac tcggcactga agggtgatgg cctttcctag   3000
 cttgaacaca gtgcttggcc aagctgacag ggagggtttg gggggcttat ctacaaccat   3060
 aagctccaca gtgttgtgtg atggcatcct aatggaggtc ttccaggtga gaagatagtg   3120
 gcagctatag atgccagtat cactgtaggt tacattgttg aggaagaatg atgtgttgtc   3180
 atcgatgctg gtggcatcca aaaattgaag tggtttgtct tctcctttct tatagagtgc   3240
 aagacccact ccatccactg gtcctcgaca ccgtaggctc acattctgac ccatttggac   3300
 cacagcactg ggccgagcaa gtagccaggt cttggggaaa gtgtcagtta cccagatttt   3360
 caggacatca ctaaggagtg aacctctata tgatgcgtca tagtaaaaac agaggtaatg   3420
 tccagtatct tggatcttca aagactggaa gaagaaattt gcctcatttt ttattgtctt   3480
 cttgtggtaa aaggacttct ccaagtcttc aaccctcatt agagcaaagg tcattccata   3540
 gattggccct tggcacctga gattcaggct ttctccaggt gccatgatgg gcccaggatg   3600
 ggctgtcaaa gttggtttgg ggtagagtcc tgctacaacc agcttcaggg ggttgctggg   3660
 ctctgaccac agggtgggga gcatctggat atgagtgcgg cagatgtaaa ccccttcatc   3720
 ctcaggtgtc aggttgtcaa tggagaatat ggccattgtc ccagttggga cttggtaatc   3780
 cacaggctct gcatatccct ctttaaacag catgaatacc aaatcctgca gccagccatg   3840
 gcagaggatg ttaacattac acccaggaag agcgggggtc tcagcctgaa tccagaagat   3900
 gggcttgggc agttggcctg gtgcctccaa ctctagaact ttactgggct ttgaccagcc   3960
 tgtctccttc cagtagcagc accggtaaag acctgcattg gactcagtaa gggcacctat   4020
 aaggaatgaa acttggaagg tcttgtggga agggcggatc caggtcatct gtgtcttatc   4080
 cttcagcagc aggaacttgc ttgatatccg agaggggctt cggcaccaaa gcgtgatgtt   4140
 ctcccaaggg gcctgggggt agttggactc tatccacaac tccggttgag ggtccatcag   4200
 aatgcaaaag agcaaaacag tgaatgtctt cagcatggtg gccccctccc ctggtctgtc   4260
 cagggtcatg gggcctctgg tgctggctgt gtgctctgag tcttgaagaa tttttctcct   4320
 cagcaggtgg tgggatggta gttgaaggcc cgctccgatg ttggagattc tccagtgagc   4380
 tcctccagat gcagcaaact gtagtcccag ccactcggaa ggctgagagg caggaggatc   4440
 acttgaaccc aggaggctga agctgcagtg agtggagatg gcaccagtgc attccagcct   4500
 gggtgacaga gagaggcttt ctttcccctc tccaggatgt gtgtagaaag aagatatctg   4560
 gaatttctca ggagactgag aaaacagcaa actcctcctt caacatctct tcttctccca   4620
 cttttatccg gtcagtttca tggcccagac ccagtcaaga actcttcttc tctgctagtg   4680
 tttctcataa gggtatagtt gtctgcatac caatagctgg ataaacacta aagctctttc   4740
 ttaggaacgc tagtagccag aaaaatctct tccatctcac tgatcccaaa tcttcccatg   4800
 ttgcagccag aaaccacctt gcaaaagtca ccaggcagag tcttcactta ggctggtatc   4860
 aaataatgat tcattcatca ggattgaatt gaaaactctt gagtgccaga aaggattcct   4920
 tgttagacag gatggtctcg atctcctgac ctcgtgatcc acccgcctca gcctcccaaa   4980
 gtgctgggat tacaggcatg agccactgcg cccggccaat aagctgattc ttaatggaga   5040
 tgacaggaac tattctgctt gaccagtaga gtgctttcca agatcttgat catcatttca   5100
 ctggtagatt attgcagaaa ccctcatgct cctaaacgac cataagaaac tgagctcaaa   5160
 tttgaaggca tcacttgtat cttaaaagca gaatggagga gccaagatgg ccgaatagga   5220
 acagctctag tctacagctc ccagcgtgag cgccgcagaa gacgggtgat ttctgcattt   5280
 tccatctgag gtaccgggtt catctcacta gggagtgcca gacagtgggc acaggtcagt   5340
 gggtgcgcgc accgtgcgcg agccgaagca gggcgaggca ttgcctcgct tgggaagcac   5400
 aaggggtcag ggagttccct ttctgagtca aagaaagggg tgacggacgc acctggaaaa   5460
 tcgggtcact cccacccgaa tattgcgctt ttccgacggg cttaaaaaac ggcgcaccac   5520
 gagattatat cccgcacatg gctcggaggg tcctacgccc acggagtctc gctgattgct   5580
 agcacagcag tctgagatca aactgcaagg cagcagcgag gctgggggag gggagcccgc   5640
 cattgcccag gcttgcttag gtaaacaaag cagccgggaa gctcgaactg ggtggagccc   5700
 accacagctc aaggaggcct gcctgcctct gtaggctcca cctctggggg cagggcacag   5760
 acaaacaaaa agacagcagt aacctctgca gacttaaatg tccctgtctg acagctttga   5820
 agagagaagt ggttctccca gcacgcagct ggagatctga gaacgggcag actgcctcct   5880
 caagtgggtc cctgaccccc ctgacccccg acccccgagc agcctaacta ggaggcaccc   5940
 cccagcaggg ggcacactga cacctcacac acggcagggt attcccaaca gacctgcagc   6000
 tgagggtcct gtctgttaga aggaaaacta acaaacagaa aggacatcca caccaaaaac   6060
 ccatctgtac atcaccatcg tcaaagacca aaagtagata aaaccacaaa gatggggaaa   6120
 aaaacagaac agaaaaactg gaaactctaa aaagcagagc gcctctcctc ctccaaagga   6180
 acgcagatcc tcaccagcaa cggaacaaag ctggacggag aatgactttg acgagctgag   6240
 agaagaaggc ttcagacgat caaattactc caagctatgg gaggacattc aaaccaaagg   6300
 caaagaagtt gaaaactttg aaaaaaattt agaagaatgt ataactagaa taaccaatac   6360
 agagaagtgc ttaaaggagc tgatggagct gaaaaccaag gctcgagaac tacgtgaaga   6420
 atgcagaagc ctcaggagcc gatgcgatca actggaagaa agggtatcag cgatggaaga   6480
 tgaaatgaat gaaatgaagc aagaagggaa gtttagagaa aaaagaataa aaagaaatga   6540
 gcaaagcctc caagaaatat gggactatgt gaaaagacca aatctacgtc tgattggtgt   6600
 acctgaaagt gatggggaga atggaaccaa gttggaaaac actctgcagg atattatcca   6660
 ggagaacttc cccaatctag caaggcaggc caacattcag attcaggaaa tacagagaac   6720
 accacaaaga tacttctcga gaagagcaac tccaagacac ataattgtca gattcaccaa   6780
 agttgaaatg aaggaaaaaa tgttaagggc agccagagag aaaggtcggg ttacccacaa   6840
 agggaagccc atcagactaa cagctgatct ctcagcagaa actctacaag ccagaagaga   6900
 gtgggggaca atattcaaca ttcttaaaga aaagaatttt caacccagaa tttcatatcc   6960
 agccaaacta agcttcataa gtgaaggaga aataaaatcc tttacagaca agcaaatgct   7020
 gagagatttt gtcaccacca ggcctgcctt acaagagctc ctgaaggaag cactaaacat   7080
 ggaaaggaac aaccagtacc agccactgca aaaacatgcc aaattgtaaa gaccatcaat   7140
 gctaggaaga aactgcatca actaacgagc aaaataacca gctaacatca taatgacagg   7200
 atcaaattca cacataacaa tattaacctt aaatgtaaat ggactaaatg ccccaattaa   7260
 aagacacaga ctggcaaatt ggataaagag tcaagaccca tcagtgtgct gtattcagga   7320
 aacccatctc acgtgcagag acacacatag gctcaaaata aaaggatgga ggaagatcta   7380
 ccaagcaaat ggaaaacaaa acaaaaaaaa agcaggggtt gcaatcctag tctctgataa   7440
 aacagacttt aaaccaacaa agatcaaaaa agacaaagaa gggcattaca taatggtaaa   7500
 gggatcaatt caaccagaag aactaactac cctaaatata tatgcaccca atacaggagc   7560
 acccagattc ataaagcaag ttcttagaga cctacaaaga gacttagact cccacacaat   7620
 aaaagtggga gactttaaca ccccactgtc aatattagac agatcaatga gacagaaagt   7680
 caacaaggat acccaggaat tgaactcagc tctgcaccaa gcggacctta atagacatct   7740
 acagaactct ccacccccaa atcaacagaa tatacattct tctcagcacc acatcacact   7800
 tattccaaaa ttgaccacat agttggaagt aaagcactgc tcagcaaata taaaagaaca   7860
 gaaattataa caaactgtct ctcagaccat agtgcaatca aactagaact caggattaag   7920
 aaactcactc aaaaccgctc aactacatgg aaactcaaca agctgctcct gaatgactac   7980
 tgggtacata atgaaatgaa ggcagaaata aagatgttct ttgaaaccaa cgagaacaaa   8040
 gacacaacat accagaatct ctgggatgca ttcaaagcaa tgtgtaaagg gaaatttata   8100
 gcactaaatg cccacaagag aaagcaggaa agatccaaaa ttgacaccct aacatcacaa   8160
 ttaaaagaac tagaaaagca agagcaaaca cattcaaaag ctagcagaag acaagaaata   8220
 actaaaatca cagcagaact gaaggaaatc aagacacaaa aaacccttca aaaaattaat   8280
 gaatccagga gctggttttt tgaaaggatc aacaaaattg atagaccgct agcaagacta   8340
 ataaagaaaa aaagagagaa gaatcaacta gacacaataa aaaatgataa aggggatatc   8400
 accaccgatc ccacagaaat acaaactacc atcagagaat attacaaaca cctctacgcc   8460
 aaataaactt gaaaatctag aaggaatgga taaattcctc gacacataca ctctcccaag   8520
 actaaaccag gaagaagttg aatctctgaa tagaccaata acaggagctg aaattgtggc   8580
 aataatcaat agcttaccac accatgcaca gtccaggacc agatggattc actgccgaat   8640
 tctaccagag gtacaaggag gaactggtac cattccttct gagactattc cagtcaatag   8700
 aagggagcgg gaatcctcca ctaactcatt ttatgaggcc agcatcatcc tgatcccaaa   8760
 gccgggcaga gacaccacca gcacagagaa ttttagacca atatccttga ggaacattga   8820
 tgcaaaactc ctcagtaaaa tactggcaag ccgaatccag cagcacatca aaaagcttat   8880
 ccaccatgat caagtgggct tcatccctgg gatgcaagtc tggttcaata tacgcaaatc   8940
 aataaatgta atccagcata taaacagagc caaagacaaa aaccacatga ttatctcaat   9000
 agatgcagaa aaagcctttg acaaaattca acaacccttc atgctaaaaa ctctcaataa   9060
 attaggtatt gatgggacgt atttcaaaat aataagagct atctatgaca aacccacagc   9120
 caatatcata ctgaatgggc aaaaactgga agcattccct ttgaaaactg gcacaagaca   9180
 ggggtgccct ctctcaccac tcctattcaa catagtgttg gaagttctgg ccagggcaat   9240
 caggcaggag aaggaaataa agggtattca attaggaaaa gaggaagtca aattgtccct   9300
 gtttgcagat gacatgattg tatatctaga aaaccccatt gtctcagccc aaaatctcct   9360
 taagctgata agcaacttca gcaaagtctc aggatacaaa atcaatgtgc aaaaatcaca   9420
 agcattctta tacaccaaca acagacaaac agagagccaa atcatgagtg aactcccatt   9480
 cacaattgct tcaaagagaa taaaatacct aggaatccaa cttacaaggg atgtgaagga   9540
 cctcttcaag gagaactaca aaccactgct cagtgaaata aaagaggata caaacaaatg   9600
 gaagaacatt ccatgctcat gggtaggaag aatcaatatt gtgaaaatgg ccatactgcc   9660
 caaggtaatt tacagattca atgccatccc catcaagcta ccaatgactt tcttcacaga   9720
 attggaaaaa actactttaa agttcatatg gaaccaaaaa agagcccaag aattggaaaa   9780
 aactacttta aagttcatat ggaaccaaaa aggagcccgc attgccaagt caatcctaag   9840
 ccaaaagaac aaagctggag gcatcacact acctgacttc aaactatact acaaggctac   9900
 agtaaccaaa acagcatggt actggtacca aaacagagat atagatcaat ggaacagaac   9960
 agagccctca gaaataatac cacacatcta caactatctg atctttgaca aacctgacaa  10020
 aaacaagcaa tggggaaagg attccctatt taataaatgg tgctgggaaa actggctagc  10080
 catatgtaga aagctgaaac tggatccctt ccttacacct tatacaaaaa ttaattcaag  10140
 atggattaaa gacttaaatg ttagacctaa aaccataaaa accctagaag aaaacctagg  10200
 caataccatt caggacatag gcatgggcaa ggacttcatg tctaaaacac caaaagcaat  10260
 ggcaacaaaa gccaaaattg acaaatggga tctaattaaa ctcaagagct tctgttcttt  10320
 gctggggtat ctgaagactg aaaacacagc aaaagaaact accatcagag tgaacaggca  10380
 acctacagaa tgggagaaaa tttttgcaat ctactcatct gacaaagggc taatatccag  10440
 aatctacaaa gaactcaaac aaatttacaa gaaaaaaaca aacaacccca tcaaaaagtg  10500
 ggcgaaggac atgaacagac acttctcaaa agaagacatt tatgcagcca aaaaacacat  10560
 gaaaaaatgc tcatcatcac tggccatcag agaaatgcaa atcaaaacca caatgagata  10620
 ccatctcaca ccagttagaa tggcaatcat taaaaagtca ggaaacaaca ggtgctggag  10680
 aggatgtgga gaaataggaa cacttttaca ctgttggtgg gactgtaaac tagttcaacc  10740
 attgtggaag tcagtgtggc gattcctcag ggatctagaa ctagaaatac catttgaccc  10800
 agccatccca ttactgggta tatacccaaa ggactataaa tcatgctgct ataaagacac  10860
 atgcacacgt atgtttattg cggcattatt cacaatagca aagacttgga accaacccaa  10920
 atgtccaaca atgatagact ggattaagaa aatgtggcac atatacacca tggaatacta  10980
 tgcagccata aaaaatgatg agttcatgtc ctttgtaggg acatggatga aattggaaat  11040
 catcattctc agtaaactat cgcaagaaca aaaaaccaaa caccgcatat tctcactcat  11100
 aggtgggaat tgaacaatga gatcacatgg acacaggaag gggaatatca cactctgggg  11160
 actgttgtgg ggtgggggga ggggggagtg gggagggata gcattaggag atatacctaa  11220
 tgctaaatga cgagttaatg ggtgcagcac accaacatgg cacatgtata catatgtaac  11280
 aaacctgcac gttgtgcaca tgtaccctaa aacttaaagt ataataataa taaaataaaa  11340
 aaaaagaaaa aaaaacatga tgagaactgt gttctgctcc caccccctat ccctctagtc  11400
 ctcagggccc ctgctcattc caaagcaaat ctggagggct tggtctgggg ttcatggtat  11460
 gcaagtgcat ctgtccccag aattcaagag gcctgtgaac ttggatggga aaataactg   11519



      <210> 2298
      <211> 8734
      <212> DNA
      <213> Homo sapiens


      <400> 2298
 ccccggagtc tgtgtttctc tctctgggcg gaggcggcgg tactggcgga tggtgggttg     60
 aggcgccggc ggcggctgct gcgagggacg atgagtgcct ccttcgtgcc gaacggggcc    120
 agcctggaag attgtcactg taacctcttc tgcctggctg acttgacagg aattaagtgg    180
 aaaaaatatg tatggcaagg cccaacttct gcccctattc tgtttcctgt gacagaagaa    240
 gaccccattt tgagcagttt tagtcgctgc cttaaggcag atgtacttgg tgttggcggc    300
 gagatcaaag acctgaaaga agagaaattg tgaatatttt gggggggtga agaccccagt    360
 tttgctgacc ttattcacca tgacttatca gaagaagaag atggagtgtg ggagaatgga    420
 ctttcctatg aatgccgtac tctgcttttc caaagcagtt cacaatctat tggaacggtg    480
 tttaatgaac aggaattttg tacgtattgg caagtggttt gtaaagcctt atgaaaaaga    540
 tgaaaaacct ataaataaaa gtgaacactt gtcctgctcc ttcacctttt tcttgcatgg    600
 agacagcaat gtttgtacca gtgtggaaat taaccaacat caacctgtat accttctcag    660
 tgaagagcat atcacccttg ctcaacagtc taatagccca tttcaagtta tcttatgccc    720
 atttggacta aatggcactc tcacaggaca ggcattcaag atgtctgatt cagctacaaa    780
 aaaattaatt ggtgaatgga aacagttcta tcctatctca tgttgcttga aggagatgtc    840
 tgaagaaaaa caggaagata tggattggga agatgattct ttagctgcag tagaagttct    900
 tgttgctggt gtccgaatga tctacccagc atgctttgtt ctagtccctc agtcagacat    960
 tcctactcct agccctgtgg gatccactca ctgttcatct tcttgcttgg gtgtccacca   1020
 agtgcctgct tccacaagag atcctgctat gtcttcggtt acgcttacac cacctacgtc   1080
 tcctgaggaa gtccaaacag ttgatcctca gtctgtccag aagtgggtca aattttcttc   1140
 agtatctgat ggcttcaact ccgatagtac tagccaccat ggtgggaaaa tacccagaaa   1200
 attagcaaat catgtggtgg atagagtttg gcaagaatgc aatatgaaca gagcacagaa   1260
 caagaggaag tattctgctt catcaggtgg tctatgcgaa gaagcgacag ctgctaaagt   1320
 ggcatcctgg gattttgttg aagccacaca aagaacaaat tgcagttgtt tgaggcacaa   1380
 aaatctcaag tcaagaaatg ctggacaaca aggacaggca ccatctttag gtcagcaaca   1440
 acaaatactt cctaagcaca agaccaatga gaagcaagaa aagagtgaaa agccacagaa   1500
 acgccccttg actccttttc accatcgtgt gtctgttagt gatgatgttg gcatggaccg   1560
 cagattccag ccagccaaag acttgtgact ctctgctccc agacagtcaa agtgagattt   1620
 tcaaatatcc ggaactaatg atgtagcaaa agactcctca gatgcatggc accgaaatgg   1680
 caaattcacc tcaaccaccc ccacttagtc cctcaccctt gtgatgtggt tgatgaagga   1740
 gtgactaaaa caccttcaac tcctcagagt caacattttt atcaaatgcc aacaccagat   1800
 cccttggttc cttctaaacc aatggaagat aggatagaca gtttgtccca gtctttccca   1860
 cctcaatatc aggaagctgt agaacctaca gtatatgttg gtacagcagt aaacttggaa   1920
 gaagatgaag ccaatatagc ctggaagtat tacaagttcc caaagaaaaa agatgtagag   1980
 tttttaccac ctcaacttcc aagtgataaa ttcaaggatg atccagttgg accttttgga   2040
 caggaaagtg taacatcagt tacagagtta atggtgcaat gtaagaaacc tttaaaagtt   2100
 tctgatgaat tagtgcagca atatcaaatt aaaaaccagt gtctttcagc aatagcatct   2160
 gatgcagaac aagaacctaa aattgatcca tatgcatttg ttgaaggaga tgaggaattc   2220
 ctttttcctg ataaaaaaga tagacaaaat agtgagagag aagctggaaa aaaacacaag   2280
 gtagaagatg ggacatctag tgtaacagtg ttatcacatg aagaagatgc tatgtcatta   2340
 tttagtccct ctatcaagca agatgctcca cgccctacta gtcatgcccg tcctccatca   2400
 acaagtttga tttatgactc agacctggct gtctcttata ctgaccttga taatctcttc   2460
 aattctgatg aagatgaact aacacctgga tctaaaagat cagcaaatgg atcagatgat   2520
 aaagccagct gcaaggaatc aaagacagga aatctggacc cgttatcttg cataagcact   2580
 gcagatcttc ataaaatgta tcctacacca ccatcattgg aacaacatat tatgggattt   2640
 tccccaatga atatgaataa taaagaatat ggtagtatgg atacaacacc tggaggaact   2700
 gttctagaag gaaatagttc tagtatagga gcgcagttca aaattgaggt tgatgaggga   2760
 ttctgtagcc ccaaaccttc tgaaattaaa gatttttctt atgtctataa gcctgaaaat   2820
 tgtcaaattc tagtgggatg ttccatgttt gcacctctaa aaactctacc aagccaatat   2880
 ctgcccctta tcaaattgcc agaagagtgt atttaccgtc agagttggac tgttggaaaa   2940
 ttggaattgc tttcttcagg gccttcaatg ccattcatca aagagggtga tggaagtaat   3000
 atggatcaag aatatggcac tgcttataca cctcaaactc atacttcttg tgggatgcct   3060
 cctagcagtg cacctcctag taacagcgga gcaggaattc ttccttctcc atccacccct   3120
 cggtttccaa ctccaaggac tccaaggact cctcggactc ctcgtggagc tggtggacct   3180
 gctagtgctc aaggttcagt caaatatgaa aattcagact tgtattcacc agcttctacc   3240
 ccatctacat gcagacccct taattctgtt gaacctgcaa ctgtcccttc catccctgaa   3300
 gcacacagtc tttatgtaaa cctcatcctt tcagaatcag ttatgaattt gtttaaagac   3360
 tgtaactctg atagttgttg catctgtgtt tgcaacatga acatcaaggg tgccgatgtt   3420
 ggagtttaca ttccagatcc aacgcaggaa gcacaatata ggtgtacctg tggcttcagt   3480
 gctgtcatga acagaaaatt tggaaacaat tcaggattat tttttgaaga tgaactagat   3540
 atcataggac gcaatacaga ctgtggcaaa gaagcagaaa aacgttttga agctctcagg   3600
 gctacctctg ctgaacatgt taatggagga ctaaaggaat ctgaaaaatt atctgatgat   3660
 ttgatattat tgctacaaga tcagtgcact aatttatttt caccctttgg agcagcagac   3720
 caagatcctt ttcctaaaag tggtgtaatt agcaattggg tacgtgttga agagcgtgac   3780
 tgttgcaatg actgctacct tgcattagaa catgggcgtc agttcatgga taacatgtca   3840
 ggaggaaaag ttgatgaagc acttgtgaaa agttcatgct tacacccctg gtccaaaaga   3900
 aacgatgtga gtatgcagtg ctcacaggat atacttcgaa tgctcctctc tcttcagcca   3960
 gttcttcagg atgccattca gaaaaaaaga acagtaagac cttggggtgt tcagggtcct   4020
 ctcacttggc aacaatttca taaaatggct ggccgaggct cttatggaac tgatgaatcc   4080
 ccagaaccac tgccaatccc cacatttttg ttgggttatg attatgatta tctggtgctt   4140
 tctccatttg ctcttcctta ttgggagaga cttatgctgg aaccctatgg atctcaaaga   4200
 gatatagcct atgttgtact gtgtccagaa aatgaagcct tgttaaatgg agcaaaaagc   4260
 ttttttagag atcttactgc aatatatgag tcctgtcgat taggtcaaca tagacctgtt   4320
 tctcgactgt taacagatgg gatcatgaga gttggatcta ctgcatcaaa gaaactatca   4380
 gaaaagttgg tagcagaatg gttttctcag gcagctgatg gtaacaatga agcattttct   4440
 aaactcaagc tttatgcaca agtctgcaga tatgacctag gtccttatct tgcttccctg   4500
 ccattggaca gctctctact ttcccagcca aatttagttg cccctacaag tcagtctttg   4560
 attactccac ctcagatgac aaatactgga aatgctaata ctccatctgc caccttagca   4620
 tctgcagcga gcagcactat gacagtgact tcaggtgttg ccatatctac ttcagttgcc   4680
 acagctaatt caactttgac cacagcttca acttcatctt catcatcctc caacttgaat   4740
 agtggagtat catcaaataa actaccttcg tttccaccct ttggcagtat gaacagtaat   4800
 gctgcaggat ccatgtctac acaagcaaat acagttcaga gtggtcagct aggagggcaa   4860
 cagacatcag ctctacagac agctgggatt tctggagaat catcttcact tcccactcag   4920
 ccgcatcctg atgtgtctga aagcacgatg gatcgggata aagtgggaat ccccacagat   4980
 ggtgattcac atgcagtcac gtatccacct gcaattgttg tttatataat tgatcctttt   5040
 acatacgaaa atacagacga gagcactaac tcttctagtg tgtggacatt ggggctactt   5100
 cgatgctttc tagaaatggt ccagactctt cctcctcata tcaagagtac tgtttctgta   5160
 cagattattc cttgtcagta cctgttgcaa cctgtgaagc atgaagatag agaaatctat   5220
 ccccagcatt taaaatccct ggctttttcg gcctttaccc agtgtcggag gccacttcca   5280
 acatcaacca atgtgaaaac attgactggc tttggtccag gtttagccat ggaaactgcc   5340
 cttagaagtc ctgatagacc agagtgtatt cgactttatg cacctccttt tattctggct   5400
 ccagtgaagg acaaacagac agagctagga gaaacatttg gagaagctgg acagaaatat   5460
 aatgttcttt ttgtgggata ctgtttatca catgatcaaa ggtggattct tgcatcttgc   5520
 acagatctat atggagaact tttagaaact tgtatcatta acatcgatgt tccaaatagg   5580
 gctcgtcgga aaaaaagttc tgctagaaaa tttggtctac agaaactttg ggagtggtgc   5640
 ttaggacttg tacaaatgag ttcattgcca tggagagttg taattggtcg tctaggaagg   5700
 attggtcatg gagaattgaa agattggagc tgtttgctga gtcgtcgaaa cttgcagtct   5760
 ctaagtaaaa ggctcaaaga catgtgtaga atgtgtggta tatctgctgc agactcccct   5820
 agcattctca gtgcttgctt ggtggcaatg gagccgcaag gctcttttgt tattatgcca   5880
 gattctgtgt caactggttc tgtatttgga agaagcacga ctctaaatat gcagacatct   5940
 cagctaaata ccccacagga tacatcatgt actcatatac ttgtgtttcc tacttctgct   6000
 tctgtgcaag tagcttcagc tacttatacc actgaaaatt tggatttagc tttcaatccc   6060
 aacaatgatg gagcagatgg aatgggtatc tttgatttgt tagacacagg agatgatctt   6120
 gaccctgata tcattaatat ccttcctgct tctccaactg gttctcctgt acattctcca   6180
 ggatctcatt acccccatgg aggtgatgcg ggcaagggtc agagtactga tcggctacta   6240
 tcaacagaac ctcatgagga agtacctaat attcttcagc aaccattggc ccttggttac   6300
 tttgtatcaa ctgccaaagc aggtccatta cctgactggt tctggtcagc atgtcctcaa   6360
 gcacaatatc agtgtcccct ttttcttaag gcctctttgc acctccacgt gccttcagtg   6420
 caatctgacg agctgcttca cagtaaacac tcccacccac ttgactcaaa tcagacttca   6480
 gatgtcctca ggtttgtttt ggaacagtac aatgcactct cctggctaac ctgtgaccct   6540
 gcaacccagg acagacgctc atgtctccca attcattttg tggtgctgaa tcagttatat   6600
 aactttatta tgaatatgct gtgatcttca tttgatggaa ctgtgcaaga aaagaacaag   6660
 gaaaaatgga tgtttcgctg caggattaag ttacaattat cttctcagtg aaggtcattt   6720
 gtgatggggt ctaattctta ttacttcaac aaatattgtt ttgacttggg gggaggggct   6780
 ataaccctgc tatttttcat tgactctatt gaactcttta ggatgatgac tgatcataca   6840
 aaacgtatta taacattttc gtagcaaaat taaccttttt tttttccagc cacagtattt   6900
 gtgaaaagta atgagccata gtacccagtc atgttaaatg aatattaaaa gcatggagag   6960
 gaaacatgag gaacaatgaa tttcaacata tggcttcaaa acatgaaaat gttcttgtat   7020
 ggattatagt atctagtatt caaaaatgcc tgcatctctt ctcttattta ttgtaagttt   7080
 ttaaatgtat aaattgtctt atatttctta acctctttta taaaaatttt cctagaaggt   7140
 ttatactgcc ttcttgcttt aaagcctatt ggtctaaaat atatgtaatc gtcttaatta   7200
 aaaagttgca gtagggtcgc ttttagagta ttattttttt gtaagggggt gggtgggaca   7260
 gtaaatttgt attgtctcga tgtacagttt aacggggata gagggggaat aatgtccata   7320
 ccattgtgtg tggaggattt acagctaagc tgtagttgca gagtacatgt acagtaatga   7380
 agttcactgt gtttataaat tgaaaaggta ccaggtctta cagcatttta tatatcacat   7440
 ctttacagaa taacatgatg gcaatataca agtggtattg ttaggtggtt taacttagaa   7500
 taaaatgaga attcttcagt tatattttgt actatggttt agggctatga ctaatatttc   7560
 aggccatttc cggtgaaaga aacttagttt tacaagaaaa accatttgct actgaatgct   7620
 taaactaatt ttagtgttta atgttacatg cttaaatttt tttcagtttt aacagtggca   7680
 tatttaggca tggaaatatt attatgaaat ttattttcag gatctgctat aaggttgaaa   7740
 tttagcccag ctctaggcat tttacaaatt atttttcaag cagtcattct tgattgtttg   7800
 actttttttt ttaaattaaa gattgggaat gtatgtgaga gtatgccata tgtatgggtg   7860
 tgtgtgtgtg cgcgccaatc caaactgtgg gtgtaaatag attctcagtg aattctggta   7920
 ttcagactct attccactag tgaaagaacc attttttaaa cttcccttgc cttttttatt   7980
 tatttaattt tcttggtttg gagatgtcag tcccaaacac cagagtctgt acttttctat   8040
 aacacagctc agattaaggt agggcatatg ccaaggaggt tctcacctcc ctaaagaagg   8100
 gacttgaatt ttagggactt taattcaccc ctccttcaat acaactttcc cccttcttgt   8160
 ttgcacatgc caagataact gcttttatgc aggctgtacc cccttgaaaa atcctttcta   8220
 cagtgctgct cacaaaagag cccaagttcg cctcctacct gcattgctga cttgaattca   8280
 cagtcgccga gtctacctag ctttcttgga agcagtctag ccaaaatttc tatttggtac   8340
 cgttcaccta attatctaca agaacaaaat ccagttgtat ttaccaaaaa ctctacttcc   8400
 aggtgtttgt tttagttttt tttttttact gaaacttgtt tttggtgaat acctctgtgc   8460
 cttagaatta aatatcactt tccttatgaa caacataacc ttccttcaga ttgtgtatat   8520
 gaaaacatta gcaagtcttg ttttttctat gaagcaaaca caattggtga caaaggttgt   8580
 caatcatttc ttcaaaatta taatgcagtt ctaatggtca gcatattttg atattaaatt   8640
 taaagatcac ctctctgcat ttgtttttaa attatgctaa tacaccacac attatgttgg   8700
 tatgttttgt tctgtacttt ctttaaaaaa aaaa                               8734



      <210> 2299
      <211> 6042
      <212> DNA
      <213> Homo sapiens


      <400> 2299
 atgacaggat caaattcaca cataacaata ttaactttaa atataaatgg actaaattct     60
 gcaattaaaa gacacagact ggcaagttgg ataaagagtc aagacccatc agtgtgctgt    120
 attcaggaaa cccatctcat gtgcagagac acacataggc tcaaaataaa aggatggagg    180
 aagatctacc aagcaaatgg aaaacaaaaa aaggcagggg ttgcaatcct agtctctgat    240
 aaaacagact ttaaaccaac aaagatcaaa agagacaaag aaggccatta cataatggta    300
 aagggatcaa ttcaacaaga ggagctaact atcctaaata tttatgcacc caatacagga    360
 gcacccagat tcataaagca agtcctgagt gacctacaaa gagacttaga ctcccacaca    420
 ttaataatgg gagactttaa caccccactg tcaatattag acagatcaac gagacagaaa    480
 gtcaacaagg atacccagga attgaactca gctctgcacc aagcagacct aatagacatc    540
 tacagaactc tccaccccaa atcaacagaa tatacatttt tttcagcacc acaccacacc    600
 tattccaaaa tcgaccacat agttggaagt aaagctctcc tcagcaaatg taaaagaaca    660
 gaaattataa caaactatct ctcagaccac agtgcaatca aactagaact caggattaag    720
 aatctcactc aaagccgctc aactacatgg aaactgaaca acctgctcct gaatgactac    780
 tgggtacata acgaaatgaa ggcagaaata aagatgttct ttgaaaccaa cgagaacaaa    840
 gacaccacat accagaatct ctgggacgca ttcaaagcag tgtgtagagg gaaatttata    900
 gcactaaatg cctacaagag aaagcaggaa agatccaaaa ttgacaccct aacatcacaa    960
 ttaaaagaac tagaaaagca agagcaaaca cattcaaaag ctagcagaag gcaagaaata   1020
 actaaaatca gagcagaact gaaggaaata gagacacaaa aaacccttca aaaaaatcaa   1080
 tgaatccagg agctggtttt ttgaaaagat caacaaaatt gatagactgc tagcaagact   1140
 aataaagaag aaaatagaga agaatcaaat agatgcaata aaaaatgata aagggaatat   1200
 caccaccaat cccacagaaa tacaaactac catcagagaa tactataaac acctctatgc   1260
 aaataaacta gaacacctag aagaaatgga taaattcctg gacatataca ccctcccaag   1320
 actaaaccag gaagaagttg aatctgtgaa tagaccaata acaggttctg aaattgaggc   1380
 aataattaat agtctaccaa ccaaaaaaag tccaggacca gacagattca cagctgaact   1440
 ctaccagagg tacaaagagg agctggtacc attccttctg aaactattcc aatcaataga   1500
 aaaagaggga atcctcccta attcatttta tgaggccagc atcatcctga tatcaaagcc   1560
 tggcagagac acaacaaaaa aagagaattt tagaccaata tccctgatga acatcgatgc   1620
 aaaaatcctc aataaaatac tggcaaacca aatccagcag cacatcaaaa agcttatcca   1680
 ccaccatcaa gttggcttca tccctgggat gcaaggctgg ttcaacatac tcaaatcaat   1740
 aaacgtaatc catcatataa acagaaccaa agacaaaaac cacatgatta tctcaataga   1800
 agcagaaaag gcctttgaca aaattcaaca gccctttatg ctaaaaactc tcaataaact   1860
 aggtattgat gggacatatc tgacatatct caaaataata agagctattt atgacaaacc   1920
 cacagccaat atcatactga atgggcaaaa actggaagca ttccctttta agactggcac   1980
 aagacaggga tgtcctctct caccactcct attcaacata gtgttggaag ctctggccag   2040
 ggcaatcagg caagagaaag aaataaaggg tattcaatta ggaaaagagg atgtcaaatt   2100
 gtccctgttt gcagatgaca tgattgtata tttagaaaac cccatcgtct cagcccaaaa   2160
 tctccttaag ctgataagca acttcagcga agtctcagga tacaaaatca atgtgcaaaa   2220
 atcacaagca ttcctataca ccaataacag acagacagag agccaaatca tgagtgaact   2280
 cccattcaca attgcttcaa agagaataaa atacctagga atacaactta caagggatgt   2340
 gaaggacctc ttcaaggaga actacaaacc actgctcaat gaaataaaag aggacacaaa   2400
 caaatggaag aacattccat gctcatgggt aggaggaaga atcaatctcg tgaaaatggc   2460
 catactgccc aaggtaattt acagattcaa tgccatcccc atcaagctac caatgacttt   2520
 cttcacagaa ttggaaaaaa ctactttaaa gttcatatgg aaccaaaaga gagccctcat   2580
 tgccaagtca tccctaagcc aaaagaacaa aactggaggc atcacgctac ctgacttcaa   2640
 actatactac aaggctacag taaccaaaac atcatggtac tggtaccaaa acagagatat   2700
 agatcaatgg aacagaacag agccctcaga aataatgcca catatctaca actatctgat   2760
 ctttgacaaa cctgacaaaa acaagcaatg gggaaaggat tccctattta ataaatggtg   2820
 ctgggaaaac tggctagcca tatgtagaaa gctgaaactg gatcccttcc ttacacctta   2880
 tacaaaaatc aattcaagat ggattaaaga tttaaacgtt agacctaaaa ccataaaaac   2940
 cctagaagaa aacctaggca ttaccattca ggacataggc atgggcaagg acttcatgtc   3000
 caaaacacca aaagcaatgg caacaaaagc caaaattgac aaatgggatc taattaaact   3060
 aaagagcttc tgcacagcaa aagaaactac catcagagtg aacaggcaac ctacaacatg   3120
 ggagaaaatt ttcgcaacct actcatctga caaagggcta atatccagaa tctacaatga   3180
 actcaaacaa atttacaaga aaaaaatcaa acaaccccat caaaaattgg gcaaaggata   3240
 tgaacagaca cttctcaaaa gaagacattt atgcagccaa aaaaacacat gaaaaaatgc   3300
 tcaccatcaa tggccatcag agaaatgcaa atcaaaacca caatgagtta tcatctcaca   3360
 ccagttagaa tggcaatcat taaaaagtca ggaaacaaca ggagctggta ttttgaaaag   3420
 atcaacaaaa ttgatagact gctagcaaga ctaataaaga aaaaaagaga gaagaatcaa   3480
 atagacgcaa taaaaaatga taaaggggat atcaccactg atcccacaga aatacaaact   3540
 accaccagag aatactataa acacctctat gcaaataaac tagaaaatct agaagaaatg   3600
 gataaattcc tcgacacata caacctccca agactaaagc aggaagaagt tgaatctctg   3660
 aatagaccaa taagaggctc tgaaattgtg gcaataatca atagcttacc aaccaaaaaa   3720
 agtccaggac cagatggatt cacagccgaa ttctaccaca ggtacaaaga ggagctggta   3780
 ccattgcttc tgaaactatt ccaatcaata gaaaaagagg taatcctccc taactcattt   3840
 tatgaggcca gcatcatcct gataccaaag cctgacagag acacagcaaa aaaagagaat   3900
 tttagaccaa tatccttgat gaacatcgat gcaaaaatcc tcaataaaat actggcaaac   3960
 cgaatccagc agcacatcaa aaagcttatc caccatgatc aagtgggctt catccctggg   4020
 atgcaaggct ggttcaacat acgcaaatca gtaaatgtaa tccagcatat aaacagaacc   4080
 aaagacaaaa accacatgat catctcaata gatgcagaaa agtcctttga taaaattcaa   4140
 caacacttca tgctaaaaac tctcaataaa ttaggtattg atgggtcata tctcaaaata   4200
 ataagagcta cctatgacaa acccacagcc aatatcatac tgaatgggca aaaactggaa   4260
 gcattccctt tgaaaactgg cacaagacac ggatgccccc tctcaccact cctattcaac   4320
 atagtgttgg aagttctggc cagagcaatc aggcaggaga aggaaataaa gggtattcaa   4380
 ttaggaaaag aggaagtcaa attgtccctg ttcatagatg acatgattgt atatctagaa   4440
 aaccccatca tctcagccca aaatctcctt aagctgataa gcaacttcag caaagtctca   4500
 ggatacaaaa tcaatgtaca aaaatcacaa gcattcttat acaccaacaa cagacaaaca   4560
 gagagccaaa tcatgagtga actcccattc acacttgctt caaagagaat aaaataccta   4620
 ggaatccaac ttacaaggga tgtgaaggac ctcttcaagg agaactacaa accactgctc   4680
 aacgaaataa aagaggatac aaacaaatgg aagaacattc catgctcatg ggtaggaaga   4740
 atcaatatcg tgaaaatggc catactgccc aaggtaattt acagattgaa tgccatcccc   4800
 atcaagctac caatgccttt cttcacagaa ttggaaaaaa ctactttaaa gttcatatgg   4860
 aaccaaaaaa gagcccgcgt tgccaagtca atcctaagcc aaaagaacaa agctggaggc   4920
 atcacactac ctgacttcaa actatactac aaggctatag taaccaaaac agcatggtac   4980
 tggtaccaaa acagagatat agatcaatgg aacagaacag agccctcaga aataacgccg   5040
 catatcaaca actatctgat ctttgacaaa cctgacaaaa acaagcaatg gggaaaggat   5100
 tctctattta ataaatggtg ctgggaaaac gggctagcca tatgtagaaa gctgaaactg   5160
 gatcccttcc ttacacctta tacaaaaatt aattcaagat ggattaaaga cttaaacgtt   5220
 agacctaaaa ccagaaaaac cctagaagaa aacctaggca ttaccattca ggacataggc   5280
 atgggcaagg acttcatgtc taaaacacca aaagcaatgg caacaaaaga caaaatagac   5340
 aaatgggatc taattaaact aaagagcttc tgcacagcaa aagaaactac catcagagtg   5400
 aacaggcaac ctacaaaatg ggagaaaatt ttcgcaacct actcatctga caaagggcta   5460
 atatccagaa tctacaatga actcaaacag atttacaaga aaaaaacaaa caaccccatc   5520
 aaaaagtggg cgaaggacat gaacagacac ttctcaaaag aagacattta tgcagccaaa   5580
 aaacacatga aaaaatgctc atcatcactg gccatcagag aaatgcaaat caaaaccaca   5640
 atgagatacc atctcacacc agttagaatg gcaatcatta aaaagtcagg aaacaacagc   5700
 actattcaca gtagcaaaga catggattca acccaaatgt gcatcaatga tacactgtat   5760
 gaagaaagtg tagaacatat acaccatgaa atacaatcca gccataaaaa aggagttcac   5820
 atcctttgca gcaatatgga tggagctgaa agccactttc ctaagcaaac taatgcaaga   5880
 acagaaagcc aaatactgca tgttctcact tggctttctt ttaacccacc agttacaatt   5940
 actaaagttc atgaaaatgt ctaccagcca agtaccactc gtaacactga aacaacgcag   6000
 ggagtcccaa gaaccaggga agaccaagaa gcatatttat aa                      6042



      <210> 2300
      <211> 729
      <212> DNA
      <213> Homo sapiens


      <400> 2300
 tgcttggcac gaggcaattt taaaaaagaa aaaagaattt catagctgtg tgccctgtca     60
 tccccttcag gcaaatgaaa gaaatctgtc cacatgaggg tgcctccctc tttcaaggca    120
 ccctccccat cttgacccaa gtcagtacag cttctcacac cctgtacccc atgtctgctg    180
 ctcaccagtt gcttgtgtga cttgcgcctg ctctttgcag ctcctcaagt tcatcccaga    240
 gaagagtgac attgacctcc tggaggagca caagcatgaa attgagcgga tggcccgtgc    300
 tgaccgcttc ctctatgaaa tgagcaggtt gggccatggg catggtgggg attcaagcag    360
 gtggggttct ggcaggtggg gcaggtgggg ctctgccaag aggaagggga tggaggtggg    420
 caggcttgag aggagactgg agctggctcc gggagctggg gctggccagg ataggggtgg    480
 gatacctcaa tatatggttc accttgtcta caggattgac cactaccagc agcgactgca    540
 agccctcttc ttcaagaaga aattccagga gcggctggct gaggcaaagc ccaaagtgga    600
 aggtagggct gagggttgca ggaggcttag agtgcagact tatctgagaa aggcagcgtg    660
 gctgggagcc agtgaatagg ggcagaggga aaccaaattc ttattctcaa cccaaaaaca    720
 aaaacaaaa                                                            729



      <210> 2301
      <211> 541
      <212> DNA
      <213> Homo sapiens


      <400> 2301
 accaaggagc cagacccaca cagatggatt tggggatcag tttggttatc ttagggccag     60
 tgctgagatc cttgcaatgg gaaatgggat gctgttgatt tccaggaagt gacctcacaa    120
 tgactcaagc taccacttag tgttgattgt gatgaaatgc cagctgtgca tatgccattg    180
 ggagctaaag tggctgctgc acttgaccac tatgaagact ggtgtggaag ggtccttctg    240
 gatgtaactt gggcagggtc cccaacgcca gagccatgga actgtaagga gccacacagc    300
 cggaggtgaa tggtgttgaa tgagggaagc ttcatctgtg tttacagcca ctccccattg    360
 ctcacattcc tgcctgagct ctgccttctc tcagatcagc agcagcatta gattctcata    420
 ggagcatgca ccccattgtg aaccatgcat gtgagggatc tacgttgcgc tgtccctatg    480
 agaatctaat gcctgatgct ctgtcacttt ctccaatatt atcttccagc tcatgccgaa    540
 t                                                                    541



      <210> 2302
      <211> 6050
      <212> DNA
      <213> Homo sapiens


      <400> 2302
 ggcttcccca cgggaggacg cgaggccccg gcccagccat ggccccctgg cgcaaagctg     60
 acaaggagcg gcacggcgtg gccatataca acttccaagg cagcggagcc ccccagctct    120
 ccctgcagat cggcgatgtg gtgcgaatac aggagacgtg tggagactgg tataggggat    180
 acctcataaa gcacaaaatg ttacagggca tttttcctaa gtcatttatc cacatcaagg    240
 aagtgacagt tgagaaaaga agaaatactg agaacatcat tcctgcagaa attcctctgg    300
 cacaagaagt gacaacgaca ctttgggaat ggggaagcat ctggaaacaa ctctatgtgg    360
 ccagcaaaaa ggagcgtttt ctccaggtgc agtccatgat gtacgatctg atggagtgga    420
 ggtcccagct tctctcagga accttaccca aggatgagct gaaggaactg aagcagaaag    480
 tcacgtccaa aattgactat ggcaacaaaa tccttgagct tgatttgatt gtcagagatg    540
 aagacggaaa tatcttggac cctgataata ccagtgtcat cagcttgttc catgcacatg    600
 aggaagcaac tgataaaatc acagagcgta tcaaagaaga aatgtcaaaa gaccagccag    660
 attatgcaat gtattcccgg atctcctcat cccccaccca tagcctctat gtgtttgtga    720
 gaaactttgt gtgcagaatt ggggaagatg ctgagctctt catgtctctc tacgacccca    780
 acaagcaaac ggtcataagt gagaactacc tagtgcgatg gggcagccgg ggcttcccta    840
 aggagattga gatgctcaac aatctgaagg tggtcttcac ggatcttgga aacaaagacc    900
 tcaacaggga taaaatttac ttgatttgtc aaatagtccg ggtcggcaag atggatctta    960
 aggatactgg tgcaaagaag tgcacgcagg gactgaggag gccctttggg gtggcagtta   1020
 tggatataac agacatcatc aaggggaaag cagagagtga tgaagaaaag cagcacttca   1080
 ttccttttca cccggttaca gctgagaatg acttcctaca cagcctgctg ggcaaagtca   1140
 tagcctccaa gggggacagt ggagggcaag gcctctgggt gaccatgaag atgctggtgg   1200
 gtgacatcat tcagattcgc aaggactatc cacacctggt ggacaggacc accgtggtgg   1260
 ccaggaagct gggattccca gagatcatca tgccagggga tgtcaggaac gacatctaca   1320
 ttactctctt acaaggtgac tttgacaagt acaacaagac cacacagagg aatgtggaag   1380
 tcatcatgtg tgtgtgcgcg gaggatggca aaacgctgcc taatgcaatt tgcgtgggag   1440
 caggggacaa gcccatgaat gagtatcgct ccgttgtgta ctatcaagtc aaacagccac   1500
 gctggatgga aacagtcaag gtggctgtcc ctattgaaga catgcagagg atccatctgc   1560
 gattcatgtt tcgacatcgg tcatctctgg aatctaaaga taaaggagaa aagaactttg   1620
 ccatgtccta tgtgaagctg atgaaagaag atgggactac tctacacgat ggattccatg   1680
 acttagttgt cctcaagggg gacagcaaga agatggagga tgccagcgca tacctgaccc   1740
 ttccttctta tcgacaccat gtggaaaaca agggggccac gctgagcagg agctccagca   1800
 gtgttggggg gctttctgtc agctcccggg atgtgttctc catttccacc ctggtgtgct   1860
 ccacaaagct cactcagaat gtgggcttgc tgggtttgct gaagtggcgt atgaagcctc   1920
 aactgctaca ggagaattta gaaaagttga agattgtgga tggagaggaa gtggtgaagt   1980
 ttctccagga tactctggat gccctcttca acatcatgat ggagcattct caaagtgatg   2040
 aatatgacat cctcgtcttt gatgccttga tttacataat aggactcatt gcagaccgga   2100
 aatttcagca tttcaacacc gttctggagg cttacatcca acagcatttc agtgcgacct   2160
 tggcttacaa gaaattgatg acagtgctga agacttactt ggatacctcc agcagagggg   2220
 agcaatgtga gccaatccta agaacgctga aggctttgga atatgtgttc aagttcattg   2280
 ttcggtcgag gacattattt tcacagcttt atgaaggcaa agaacagatg gagtttgaag   2340
 aatccatgag acggctcttt gaatccatca acaatctgat gaaaagtcaa tacaaaacta   2400
 ccatcctttt gcaggtggcg gctttgaaat acatcccatc tgtcctgcat gatgtagaaa   2460
 tggtctttga tgcgaagtta ctcagccaac tcctgtatga gttctacacc tgcatccctc   2520
 ctgtgaaact ccagaagcag aaagtacagt ctatgaatga gatagtccag agcaacctct   2580
 ttaaaaagca agaatgccgg gacattctgc ttcctgtcat caccaaagag ctgaaggagc   2640
 tgctggagca gaaggatgac atgcaacacc aggtcctgga gaggaagtac tgcgttgaat   2700
 tgctcaacag catcttggaa gtccttagct accaggatgc ggccttcacc taccaccata   2760
 tccaagagat catggtccag ctgctgcgga cagtgaaccg gacagtcatc accatgggcc   2820
 gggatcacat tctgattagt cactttgtgg catgtatgac agccatctta aaccagatgg   2880
 gtgaccagca ctactccttc tacattgaga ccttccagac cagctctgaa cttgtggact   2940
 tcttgatgga gaccttcatc atgttcaagg acctcattgg aaagaacgtg taccctggag   3000
 actggatggc catgagcatg gttcaaaaca gggtcttcct gagagctatc aacaagtttg   3060
 cagaaaccat gaaccagaag ttcctagaac acacgaactt tgagttccag ctgtggaaca   3120
 actattttca tctggcagtg gcttttatca cccaggattc tctgcagctg gagcagttct   3180
 cacacgccaa atacaacaaa atcctgaata agtatgggga catgagacgg ctaattggct   3240
 tctccatccg tgatatgtgg tacaagcttg gtcagaacaa aatctgcttc atcccaggca   3300
 tggtaggacc tatattagag atgacactta tccctgaggc tgagctccgg aaagccacca   3360
 taccaatctt cttcgacatg atgctgtgtg aatatcaaag aagtggggat ttcaaaaagt   3420
 ttgaaaacga aatcatcctg aagctggacc acgaggtaga agggggccga ggcgacgagc   3480
 agtacatgca gctcctggag tcaatcctga tggaatgtgc tgcagagcac ccaaccattg   3540
 ccaagtcggt ggagaacttc gtgaacctgg tcaaaggcct cctggagaag ctgctggatt   3600
 accggggtgt gatgacagat gagagcaaag acaaccgcat gagctgcact gtgaacctgc   3660
 tgaatttcta caaagataac aacagggagg agatgtacat aaggtacctg tacaaactcc   3720
 gcgatcttca cctggactgt gacaattaca cagaggctgc ctacacgctc cttctccaca   3780
 cctggcttct caagtggtcg gatgagcagt gtgcatcaca ggtcatgcag acaggccagc   3840
 agcaccccca gacacaccgg cagctgaagg agacgctcta cgagaccatc ataggctact   3900
 ttgacaaagg aaagatgtgg gaagaggcca taagtctgtg caaggagctg gcggaacagt   3960
 acgagatgga gatctttgac tatgagctgc tcagccagaa cctgatccag caggcaaaat   4020
 tctatgaaag catcatgaaa atcctcaggc ccaaaccaga ctactttgct gttggatact   4080
 acggccaggg attcccctcc ttcctgcgga acaaagtgtt catctaccgc gggaaggaat   4140
 atgagcgaag agaagatttc cagatgcagc tgatgaccca gttccccaat gcagagaaga   4200
 tgaacaccac ctctgccccg ggagatgatg tgaagaatgc cccaggccag tatatccagt   4260
 gcttcactgt ccagcctgtc ttggatgaac atcccaggtt caagaataag ccagtgcctg   4320
 accagattat aaacttctac aaatccaact acgtgcaaag gttccactac tcccggcccg   4380
 tgcgcagggg gaccgtagac ccagagaatg agtttgcttc catgtggatt gagagaacct   4440
 ccttcgtgac tgcatacaag ctgccgggga tcctgcgctg gtttgaggtg gtgcacatgt   4500
 cgcagaccac aattagtcct ctggagaatg ccatagaaac catgtccacg gccaatgaga   4560
 agatcctgat gatgataaac cagtaccaga gtgatgagac cctccccatc aacccactct   4620
 ccatgctcct gaacgggatt gtggaccctg ctgtcatggg aggcttcgcc aagtatgaga   4680
 aggccttctt cactgaagag tatgtcaggg accaccctga ggaccaggac aagctgaccc   4740
 acctcaagga cctgattgca tggcagatcc ccttcttggg agctgggatt aagatccatg   4800
 agaaaagggt gtcagataac ttgcgaccct tccatgaccg gatggaggaa tgtttcaaga   4860
 acctgaaaat gaaggtggag aaggagtacg gtgtccgaga gatgcctgac tttgacgaca   4920
 ggagagtggg ccgccccagg tctatgctgc gctcatacag acagatgtcc atcatctctc   4980
 tggcttccat gaattctgac tgcagcaccc ccagcaagcc tacctcagag agctttgacc   5040
 tggaattagc atcacccaag acgccgagag tggagcagga ggaaccgatc tccccgggga   5100
 gcaccctgcc tgaggtcaag ctgcggaggt ccaagaagag gacaaagaga agcagcgtag   5160
 tttttgcgga tgagaaagca gctgcagagt cggacctgaa gcggctttcc aggaagcatg   5220
 agttcatgag tgacaccaac ctctcggagc atgcggccat ccccctcaag gcgtctgtcc   5280
 tctctcaaat gagctttgcc agccagtcca tgcctaccat cccagccctg gcgctctcag   5340
 tggcaggcat ccctgggttg gatgaggcca acacatctcc ccgcctcagc cagaccttcc   5400
 tccaactctc agatggtgac aagaagacac tcacacggaa gaaggtcaat cagttcttca   5460
 agacaatgct ggccagcaaa tcggctgaag aaggcaaaca gatcccagac tcgctgtcca   5520
 cggacctgtg agctgctgct gactagggct gcatgggaga gccagggagg ggagtttctg   5580
 gaagaggaaa gccatgcgtg gaacatcgaa gcctcagaga gtgggagact gtccccatca   5640
 gttgtcctta cttagaggag acagagaggc caatcaggtc ccagagctgg agtgctaaca   5700
 agcccagcat cccctggggc tgtgatcatg gtggatgagg aagcctcaac gtagattcct   5760
 gaactcaagg taccagcaag aatgccttct cccagtgtgc tctccccaac atcctaggca   5820
 cagctttcat aacccagttt cttaggtgta agaaactgct tttatctcat ttattaagtc   5880
 tcagaactta acagaaaagg aagcctttta aatattcttt ttaattttat tttagattaa   5940
 cagttttgta ctttacattt ttttatacaa ccaaccagtt tcttttctag ccaatcatct   6000
 ctgaagagtt gctgtttctt actgacaata aaaaatgttc tcttggttcg              6050



      <210> 2303
      <211> 1137
      <212> DNA
      <213> Homo sapiens


      <400> 2303
 ctgacccgtc tgtgactctg tgtccttggg gacctcctat tctaaacaca agagcgtggc     60
 ctgctgtcac cgtcaccatc ctggcatctg cagaagagcc accaagcgct gcctcctgag    120
 aattttgcgt ggccctctgt ctctggctcc tttcatagag tgtgatgtcc tcaaggtcca    180
 tccacactgt ggccggcatc agagccttgt tccttttcat ggctgagtcc tgctccatgg    240
 tggcgtttgt atgtgcgagg cctggggtag caaacttttc tgcagagatc cagatggcaa    300
 atgttttagc ctttgcaggc tggacagtct ctgcctgcca ttgtagcggg aaagccacca    360
 caagcaatat gtcaacaagt gggtgtggcc gtgtgccaat aaaacagctg tgtttaatca    420
 atgctgggca gccctgcagc ttggtgacat cagtgggcca ctggctactg ggtgtttttt    480
 ccatcctgcc ctgttccctg ctggcaccag gggaaaaagg cccatacagg agtctgttcc    540
 aggtcaccag atcctgcttt ctggcgacca tgctcaggct gtagctgggg gaactctctt    600
 cccgccctcc tgggacctct cgagcctctt gagtctgctc ccagtgccgt tcaccgggtg    660
 gtgaggatgt ggtctcgcaa cagacgcctt ctttgcaggc tgctaccctg gaactgtttt    720
 taaatgtggg tgatgctgcc ccccaggggg cactgggcga tgtttgggga cgtgtggtta    780
 tcacaactgg gatgctccat ctgatcttct gatctccctc aaagagctgc gtctcaggtc    840
 gcaggtgaac tttctggatg gtgtggtctg cgtgcgtgtg tgcgtctggc tgcctgccag    900
 gagggaaccg ctgttgctgc cctgtgtcgc tgtcgcctga acgtattgct gtcctggggg    960
 gactgctccc tagaaagcct ccgtgccgtg tcgttggtga gcgccggtct gtgctgacac   1020
 tgcaggctac ttcccagtgc ccacgatgac agctctgcct ctgaagtgag aagcggagac   1080
 gccactggga ggggcggggg gcggagggca cggggttcaa gtgccaggct gagccta      1137



      <210> 2304
      <211> 2132
      <212> DNA
      <213> Homo sapiens


      <400> 2304
 attgaacgcc tgcgatagat cgcgttaggc acgggccgac ccacgcgtcc gccactgggc     60
 atctctttca aggtttctgc tgggtttctg aactgctggg tttctgcttg ctcctctgga    120
 gatgcagcgt ctgttgactc cagtgaagcg cattctgcaa ctgacaagag cggtgcagga    180
 aacctccctc acacctgctc gcctgctccc agtagcccac caaaggtttt ctacagcctc    240
 tgctgtcccc ctggccaaaa cagatacttg gccaaaggac gtgggcatcc tggccctgga    300
 ggtctacttc ccagcccaat atgtggacca aactgacctg gagaagtata acaatgtgga    360
 agcaggaaag tatacagtgg gcttgggcca gacccgtatg ggcttctgct cagtccaaga    420
 ggacatcaac tccctgtgcc tgacggtggt gcaacggctg atggagcgca tacagctccc    480
 atgggactct gtgggcaggc tggaagtagg cactgagacc atcattgaca agtccaaagc    540
 tgtcaaaaca gtgctcatgg aactcttcca ggattcaggc aatactgata ttgagggcat    600
 agataccacc aatgcctgct acggtggtac tgcctccctc ttcaatgctg ccaactggat    660
 ggagtccagt tcctgggatg gtcgttatgc catggtggtc tgtggagaca ttgccgtcta    720
 tcccagtggt aatgctcgtc ccacaggtgg ggccggagct gtggctatgc tgattgggcc    780
 caaggcccct ctggccctgg agcgagggct gaggggaacc catatggaga atgtgtatga    840
 cttctacaaa ccaaatttgg cctcggagta cccaatagtg gatgggaagc tttccatcca    900
 gtgctacttg cgggccttgg atcgatgtta cacatcatac cgtaaaaaaa tccagaatca    960
 gtggaagcaa gctggcagcg atcgaccctt cacccttgac gatttacagt acatgatctt   1020
 tcatacaccc ttttgcaaga tggtccagaa gtctctggct cgcctgatgt tcaatgactt   1080
 cctgtcagcc agcagtgaca cacaaaccag cttatataag gggctggagg ctttcggggg   1140
 gctaaagctg gaagacacct acaccaacaa ggacctggat aaagcacttc taaaggcctc   1200
 tcaggacatg ttcgacaaga aaaccaaggc ttccctttac ctctccactc acaatgggaa   1260
 catgtacacc tcaaccctgt acgggtgcct ggcctcgctt ctgtcccacc actctgccca   1320
 agaactggct ggctccagga ttggtgcctt ctcttatggc tctggtttag cagcaagttt   1380
 cttttcattt cgagtatccc aggatgctgc tccaggctct cccctggaca agttggtgtc   1440
 cagcacatca gacctgccaa aacgcctagc ctcccgaaag tgtgtgtctc ctgaggagtt   1500
 cacagaaata atgaaccaaa gagagcaatt ctaccataag gtgaatttct ccccacctgg   1560
 tgacacaaac agccttttcc caggtacttg gtacctggag cgagtggacg agcagcatcg   1620
 ccgaaagtat gcccggcgtc ccgtctaaag gtgttctgca gatccatgga aagcttcctg   1680
 ggaaacgtat gctagcagag cttctccccg tgaatcatat ttttaagatc ccactcttag   1740
 ctggtaaatg aatttgaatc gacatagtag ccccataagc atcagcccct gtagagtgag   1800
 ggagccatct cctagccggg cccttcattc cctctcccat gcctgcaatc actgtcctgg   1860
 gcttatggtg cctatggact aggggtcctt tgtgaaagag caagatggag caatggagag   1920
 aagacctctt cctgaatcac tggactccag aaatgtgcat gcgagatcag ctgttgcctt   1980
 caagatccag ataaactttc ctgtcatgtg ttagaacttt attattatta atattgttaa   2040
 acttctgtgc tgttcctgtg aatctccaaa ttttgtacct tgttctaagc taatatatag   2100
 caattaaaaa gagagaaaaa ggaaaaaaaa aa                                 2132



      <210> 2305
      <211> 1855
      <212> DNA
      <213> Homo sapiens


      <400> 2305
 catagagcaa gagtggacag aagcagggag tccccaggag gggacctcag gcatccaggg     60
 agggtgagga gggacattac tttgtcagga catccaagac tcagtactca gcatgttgtg    120
 ctcctgaggg aggatgaggt tggagatcca ggaaccaaag acctgggcca cccccagcat    180
 ggcagtccca tccaggagac acagagtgag gtggtcaccc tggtcagtcc actcccaggg    240
 agtgacatgg cagctttacc ggcttggaga gctacttctg ggctgacact ctggccccat    300
 acagcagaag gcagggatct gctgggagct gagaacagag ccttgactgg tgggcaacaa    360
 gcagaggatc ccaccttggc ctcaggggct tatcagtggc ctggctctgt tgagaagctg    420
 caagggtcag tatggtgtga tgctgagacg ctgttgagca gctcgaggac tggtgggcag    480
 gctcccccat ggctgacaga ccacgatgtg cagatgctcc gtctgttggc acagggggag    540
 gtggtggaca aagccagggt ccccgcccat gggcaggtgc tacaggttgg cttctccact    600
 gaggctgccc ttcaggacct gtcctctccc aggctcagcc aactctgttc ccaagggctc    660
 tgtggcctga tcaagaggcc tggggacctg cctgaggtcc tgtccttcca cgtagatcgt    720
 gtgctggggc tgcgccggag cctacctgct gtggcccgcc gcttccatag ccccctcctg    780
 ccctaccgat acacagacgg tggagcaagg cctgtcatct ggtgggcgcc cgatgtgcag    840
 cacctgagcg acccagatga ggatcagaac tctctggcct tgggctggct gcagtatcag    900
 gccctgctgg cacacagctg caactggcca ggccaggccc cgtgcccggg catccaccat    960
 accgagtggg cacgcctggc gctcttcgac ttcctgttgc aggtccacga ccgcttggat   1020
 cgctactgct gtggcttcga gcctgagccc tcagacccct gtgtggaaga gaggctccga   1080
 gagaaatgcc ggaacccagc cgagctgcgg ctggtccaca tcctggtccg gagcagcgat   1140
 ccatctcacc tggtctacat cgataacgct ggcaaccttc agcaccctga ggacaagctg   1200
 aactttcggc tgctggaggg catagatggg tttcctgagt ctgccgtgaa ggttctcgca   1260
 tcagggtgtc tgcagaacat gctgctgaag tcgctgcaga tggacccagt gttctgggaa   1320
 agccaaggcg gagcccaggg gctgaagcag gtcctccaga ccctggagca gcgaggacag   1380
 gtgctgctgg gacacatcca aaagcacaac ctcacactct tcagggacga ggacccataa   1440
 gccgcacaca gccctgagtc aatgagcatc catcctgatg gccacatttt cttgggctca   1500
 ctcatcttga ggacaaatgg gaaaagccag aagccagagg ggcacaagga tgtcacggga   1560
 tatttcacct gcctgggatg gtggaggtag tatggggttt tcaatctcaa agcgtccctt   1620
 tctgccttct cggctctggc tatttattcc cttgcaccaa caaatacatt cgaaaatgtt   1680
 ctgtgagctg ctcaagaaac tgtaaaaatg tgtgatgcac gtgcatatgc agagtgggag   1740
 aactttgtgt gtgtgtagag gtgtgtaggt gtgggtggca tgtgtgcccg cctgcatgca   1800
 atacctgaga ccaacctaat aaaggtacaa tcttcataga actgcaaaaa aaaaa        1855



      <210> 2306
      <211> 1227
      <212> DNA
      <213> Homo sapiens


      <400> 2306
 ttatttcgtg gccgtctccc tcccttcttg gccaaactgc ggcgctttgt gcaaacgggg     60
 caggtcccgc ggggactcca ccgggacgtg gccccgtctc cgcgcgtttt ggcaggcggg    120
 gggctgcgtg tgtctgctcc cctccctccc cctctcccct cgctcccctc tcccggtgac    180
 gattcgccgt aatgtggtgg caggaagcat gacgccgtgg gccgaggctg cctctgctct    240
 cgtcgctccc ggcggctgca ggcagcgggc gcgcagcgcg ggcggcagcc gagctacctg    300
 gcgggggcag ggccggagcg cggcgctgtc ctcacccccg ctcaggtgca gggggagtcc    360
 gcgcggggcg gggggccgag ggcggccgcg ggacccccgg ccctgctgtc cgctgccagc    420
 tggccggagc ctctgccagc ccgagcccac gttcgccccc ctgaacggca gctggcgctt    480
 ttcgtctgcc ccacaagagg ttaatctttg ttggtgttgc agcttctttg tggcttcccc    540
 aggacttgta tcctcggctt tgcaaacttg cccttttccc agccgctttg caggaggctg    600
 cggagacgaa gatgagcgga aagttggaaa ccagcaggca tcacaggacg gtccctttgg    660
 cctcgtagct gtgctgagcc tttgggtctc ctgggcccta gctgcagctc caccactcat    720
 cagcaggata cctttggcca tgaccttcac cattgctgtg gctccagcaa aagggctgtg    780
 gcccctcctc catggattag aacctgtggc tgagccacaa tccagcacgg aggataacag    840
 caaggatggg tgtgcattca gggtcttcct ctgcctacgg tcttcctcac ccacgatttt    900
 ccccaattta ttggatgctc caaatatcct cacaccgtag cccatgtcat ttgcacagca    960
 acccttgcct tcacattcag gagccagagc tcttgggtca atcaggtaga acctgagtgc   1020
 aaaagctgca gcaactcccg caagtatcgt gggcgtccgc tggccatgga agcctgtgtt   1080
 tccttgctgg ggtggggggt cactcagatt tcgagtggcc actttgttcc ctacatgcca   1140
 ggcctgcagg aaccctgcta cctggggatg ggcagagtga acccagctgc agactgctga   1200
 gaagaaaagt gacttgaagc cgggcat                                       1227



      <210> 2307
      <211> 1447
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> misc_feature
      <222> (1)...(1447)
      <223> n = a,t,c or g


      <400> 2307
 tagtagaggc ggggtttcac catgttggcc aggctgagtc ttgcgcacgg gacctcaaga     60
 gatatgcctg cctcagcctc ccaaagtgct gggattacag gcgtgagtac tccgtgccca    120
 gtcaattttt gtatttttag tagagacggg gtttcaccat gttggtcagg ctggtctcaa    180
 acttctgacc tcatgatctg cccacctcgg cctcccaaag tgctgggatt gcaggcgtaa    240
 cacnccgcgc ccaagctaat ttttaaaaat attttataga gacaggtctc actatgttgc    300
 ccaggctcgt cttgaacccc tgggcccagg cgctcctccc accttgacct cccaaagttc    360
 tggaattaca catgtgagcc aacacaccag gcccagactg ggtaatttat aaagaaattt    420
 acttctgccc acaccggccc gcctccccgc ggcgagtggc tgaggcgtag cgctgccatc    480
 cccgcacccc tgggaacatg gcgctgcgag tggtgcggag cgtgcgggcc gtgctctgca    540
 gcctgcacgt ggtcctggca cctgccgcgc cctgcctatc gaggccctgg cagcttggga    600
 tgggcgccgt ctggttactg taatctgcct gaagttggga caaaattgaa caaacaagat    660
 gagtttggtg ctttggagag tgtgaaagct gctagtgaac tctattctcc tttatcagga    720
 gaagtaaccg aaattaatga agctcttgca gaaaatccag gacttgtaaa caaatctcgt    780
 tatgaagatg gttggctgat caagatgaca ctgagtaacc cttcataact agatgaactt    840
 atgagtgaag aagcatatga gaaatacata aaatctattg aggagtgaaa atggaaccac    900
 taaataagct agtatgaaat aacgcaaccc agcagagttg tcctaaatta gtggtggata    960
 gaagacttag aatagcaact tttagcatta cccatgggaa aaaaaaacta ctgttaacac   1020
 tgctaatgaa agaagatgcc ttttaacttt ctaatgattg tagataaaca taatatgtgt   1080
 ctttttcaca acatcctatg atttttagac taggctctag tattcatgaa attatccatg   1140
 aaattatcca tggtaaaaat tagttacaaa aattacataa ttcaaagata atgttgttat   1200
 tcttaagcct tatataatat tgtaacttgt gtatgtccat acctggattt gggatgaaat   1260
 acttaatgat ctttccattg gaaataactg ggagtgaaga agtttttgtt gcttgtacag   1320
 tgtcagatga agaacaacac tatcttaatt ttgcaataca ctgcatttgc tggtgctgtt   1380
 tttatatagt gaagcaacag ctgtacagca aaataataaa atactcactt cttcgttaaa   1440
 aaaaaaa                                                             1447



      <210> 2308
      <211> 413
      <212> DNA
      <213> Homo sapiens


      <400> 2308
 tggccttctg ggcaagtttt ggtagggtgt ctgtcatttt ccctctactg ctggaaaaga     60
 agtctcaaga ggaagaatcc aggttttgag gttttgctga agatattcct gaagaatcat    120
 cccaggtgcc acactaacag aatgatccag ttgacagcta cccctgtgag tgcacttgct    180
 gatgagccag cgcatatccg agctacaggc ctgattccct ttcagatggt gagttttcag    240
 gcatcactgg aagatgaaaa cggagacatg ttctattctc aagcccacta tagggccaat    300
 gaattcgctg aagcggacct gaatcatgct gcttcacttg gaggggatta cttgggagat    360
 cttgccctga ggcttttgtg caccctagag cctgttttcc cgcaatcata cta           413



      <210> 2309
      <211> 1229
      <212> DNA
      <213> Homo sapiens


      <400> 2309
 tttcgtccgg cgccgggtcc cggagacaga cgttacgcgg gctcgagcgt cctcgggaag     60
 tgccagccag agttggtgac gaccacttcc tcgacgtggg gcgggcggac gggaagcctg    120
 gggtcgtggc caccgcctcg ggagctctgg gagcccgggt gaccgcgtag aaatgaacac    180
 agaagcggag caacagcttc tccatcacgc cagaaatggc aatgctgaag aagtaagaca    240
 actattagag accatggcga ggaatgaagt gattgctgac attaattgca aaggaagaag    300
 taagtctaac ttgggctgga cacctctaca tctggcatgc tattttggac acagacaagt    360
 ggtccaggat ctgttgaagg ctggtgcaga agtgaatgtg ttgaatgaca tgggagacac    420
 gccgcttcat cgagctgcct ttacaggacg aaaggagttg gtaatgcttc tcttagaata    480
 taatgctgat actactattg ttaatgggag tggacagaca gcaaaagaag ttactcatgc    540
 tgaagaaatc acaagcatgc ttgaagctgt agaaaggact caacaaagaa agcttgaaga    600
 attactttta gcagcagcaa gagaaggcaa aacaacagaa ctcacagctc tgctcaacag    660
 gcccaatcct cctgatgtta actgttcgga tcagttagga aatacaccct tgcattgggc    720
 agcttaccgg gcccataaac aatgggcctt aaagctttta aaaagtggag cagaccctaa    780
 tctgaagaac aaaaatgatc agaaacctct tgaccttgcc cagggtgctg aaatgaaaca    840
 cattcttgtt ggtaataagg tcatctacaa agcattgaaa cgatatgagg gccctctctg    900
 gaagagttca agattttttg gctggagatt attctgggta gtgttagagc atggagtcct    960
 ttcatggtat aggaaacagc ctgatgcagt tcataatatt tatcgccagg gatgcaaacg   1020
 cctgactcaa gcagtatgca cggtaaaatc cactgatagc tgcctcttct ttattaaatg   1080
 ctttgatgac gccattcatg gcttccgggt tcctaagaat agccttcagc agtcaagaga   1140
 ggcctggctg gaagcaatag tcgctctttc tgcttacagc gctcattact gtacacaaaa   1200
 ccagctgact gatgaggagg aggtgtatt                                     1229



      <210> 2310
      <211> 385
      <212> DNA
      <213> Homo sapiens


      <400> 2310
 ggtggaaaaa gtttgagaga aggagggagg aaaaggtgtc ctggctagca ccatgtggat     60
 tctcttgaga tgagaagaaa atgcccggct acgtccccct tctgctgctc ctgcttctcc    120
 tgaggtgttc acaacggggt ggaggagtta attttggtga gaaggatgca aaagtccccg    180
 ggacctggag agatggagtc agggtccctg gagaaggagc ctcttgggac tcagacaggg    240
 ccagtcctga gcgaaggtac ggaataggtg agtgaacctt gggaactccg gaccctgtta    300
 tctaccctca atcacctgcc acagggaggc agggacccca gcgtctttct catataccct    360
 tttaaggaaa tgctctgctt ttgat                                          385



      <210> 2311
      <211> 2114
      <212> DNA
      <213> Homo sapiens


      <400> 2311
 ctgcccgggc tgcgcggcgt ctgcaggcgc caccgctgcc tctttccggc tgtgaccctc     60
 ctcgccgccg ccgcttggct gcgtcctccg actccccgcg ccgccgagac caggctcccg    120
 ctccggttgc ggccgcaccg ccctccgcgg ccgccccctg gggatccagc gagcgcggtc    180
 gtccttggtg gaaggaacca tgaactggca tctccccctc ttcctcttgg cctctgtgac    240
 tctgccttcc atctgctccc acttcaatcc tctgtctctc gaggaactag gctccaacac    300
 ggggatccag gttttcaatc agattgtgaa gtcgaggcct catgacaaca tcgtgatctc    360
 tccccatggg attgcgtcgg tcctggggat gcttcagctg ggggcggacg gcaggaccaa    420
 gaagcagctc gccatggtga tgagatacgg cgtaaatgga gttggtaaaa tattaaagaa    480
 gatcaacaag gccatcgtct ccaagaagaa taaagacatt gtgacagtgg ctaacgccgt    540
 gtttgttaag aatgcctctg aaattgaagt gccttttgtt acaaggaaca aagatgtgtt    600
 ccagtgtgag gtccggaatg tgaactttga ggatccagcc tctgcctgtg attccatcaa    660
 tgcatgggtt aaaaatgaaa ccagggatat gattgacaat ctgctgtccc cagatcttat    720
 tgatggtgtg ctcaccagac tggtcctcgt caacgcagtg tatttcaagg gtctgtggaa    780
 atcacggttc caacccgaga acacaaagaa acgcactttc gtggcagccg acgggaaatc    840
 ctatcaagtg ccaatgctgg cccagctctc cgtgttccgg tgtgggtcga caagtgcccc    900
 caatgattta tggtacaact tcattgaact gccctaccac ggggaaagca tcagcatgct    960
 gattgcactg ccgactgaga gctccactcc gctgtctgcc atcatcccac acatcagcac   1020
 caagaccata gacagctgga tgagcatcat ggtgcccaag agggtgcagg tgatcctgcc   1080
 caagttcaca gctgtagcac aaacagattt gaaggagccg ctgaaagttc ttggcattac   1140
 tgacatgttt gattcatcaa aggcaaattt tgcaaaaata acaaggtcag aaaacctcca   1200
 tgtttctcat atcttgcaaa aagcaaaaat tgaagtcagt gaagatggaa ccaaagcttc   1260
 agcagcaaca actgcaattc tcattgcaag atcatcgcct ccctggttta tagtagacag   1320
 accttttctg tttttcatcc gacataatcc tacaggtgct gtgttattca tggggcagat   1380
 aaacaaaccc tgaagagtat acaaaagaaa ccatgcaaag caacgactac tttgctacga   1440
 agaaagactc ctttcctgca tctttcatag ttctgttaaa tatttttgta catcgcttct   1500
 ttttcaaaac tagttcttag gaacagactc gatgcaagtg tttctgttct gggaggtatt   1560
 ggagggaaaa aacaagcagg atggctggaa cactgtactg aggaatgaat agaaaggctt   1620
 ccagatgtct aaaagattct ttaaactact gaactgttac ctaggttaac aaccctgttg   1680
 agtatttgct gtttgtccag ttcaggaatt tttgttttgt tttgtctata tgtgcggctt   1740
 ttcagaagaa atttaatcag tgtgacagaa aaaaaaatgt tttatggtag cttttacttt   1800
 ttatgaaaaa aaaattattt gccttttaaa ttcttttccc ccatccccct ccaaagtctt   1860
 gatagcaagc gttattttgg gggtagaaac ggtgaaatct ctagcctctt tgtgtttttg   1920
 ttgttgttgt tgttgttgtt ttatataatg catgtattca ctaaaataaa atttaaaaaa   1980
 ctcctgtctt gctagacaag gttgctgttg tgcagtgtgc ctgtcactac tggtctgtac   2040
 tccttggatt tgcatttttg tattttgtac aaagtaaaaa taaactgtta tgagtagtaa   2100
 aaataaaaaa aaaa                                                     2114



      <210> 2312
      <211> 442
      <212> DNA
      <213> Homo sapiens


      <400> 2312
 gatacgtact gcaggggaga ccagctgcac atcctgctgg aggtgaggga ccacttggga     60
 cgcaggaagc aatatggcgg ggatttcctg agggccagga tgtcttcccc agcgctgatg    120
 gcaggtgctt caggaaaggt gactgacttc aacaacggca cctacctggt cagcttcact    180
 ctgttctggg agggccaggt ctctctgtct ctgctgctca tccaccccag tgaaggggtg    240
 tcagctctct ggagtgcaag gaaccaaggc tatgacaggg tgatcttcac tggccagttt    300
 gtcaatggca cttcccaagt ccactctgaa tgtggcctga tcctaaacac aaatgctgaa    360
 ttgtgccagt acctggacaa cagagaccaa gaaagcttct actgggtgag gcctcaacac    420
 atgcgctgtg ctgcactcac tc                                             442



      <210> 2313
      <211> 7471
      <212> DNA
      <213> Homo sapiens


      <400> 2313
 tctgcggcgc tcggagcctc ccttgcgatc ccacggccgg gactgcccgg agtgcatggg     60
 cgcgggccag ggacgctgag cggtcgcgcc atggagggcg ccgagccccg cgcgcggccc    120
 gagcgcctgg ccgaggccga gacgcgggcg gcggacggcg ggcgcctggt ggaggtgcag    180
 ctgagcggcg gcgccccgtg gggcttcacc ctgaagggcg gccgcgagca cggcgagccg    240
 ctggtcatca ccaagattga agagggcagt aaagccgcgg cggtcgacaa gttactggct    300
 ggagatgaga tcgtcggcat caatgacatt ggtctctcag ggtttagaca ggaagcgatt    360
 tgcctggtga aggggtccca taagaccctg aagctggtcg tcaaaaggag gagcgagctg    420
 ggctggaggc ctcactcctg gcatgccacc aagttctctg acagccaccc cgagctagcg    480
 gcctccccgt tcacctccac cagcggctgt ccttcctggt ccggccgaca ccacgcgagt    540
 tcttcctccc acgacctgtc cagttcctgg gagcagacga acctacagcg caccttagat    600
 cacttcagct ccttggggag cgttgacagc ctggaccacc cctccagtcg cctctcggtg    660
 gccaagtcca acagcagcat cgaccacctg ggcagccaca gcaagcgcga ctcggcctac    720
 ggctccttct ccaccagctc tagcactcct gaccacacct tgtccaaagc cgacacgtcc    780
 tccgcagaga acatcctcta cactgtgggc ctctgggagg ctcccaggca gggtggccgg    840
 caggcccagg ccgcaggcga ccctcagggc tcggaggaga agctcagttg tttcccgccc    900
 agggtccccg gtgacagcgg caaaggcccc aggccagagt acaatgccga gcccaagctg    960
 gctgcccctg ggaggtccaa ttttgggcca gtctggtatg ttcccgataa gaagaaagca   1020
 ccatcatccc cacctcctcc ccctccccct ctccgcagtg acagctttgc tgccaccaag   1080
 agccacgaga aggcccaggg ccctgtgttc tcagaggcgg ctgcggcaca gcactttacg   1140
 gccctggccc aggctcagcc tcgtggtgac cggagaccag agctcaccga tcggccttgg   1200
 aggtcagcac acccggggag cctcgggaag ggatcgggag gcccgggctg cccacaggag   1260
 gcccacgcag acggcagctg gccgccctcc aaggatggag cttccagtag gctgcaggcc   1320
 tctctgtcca gctcagatgt gcgcttccct cagtctcctc atagcggccg acaccctccc   1380
 ctatacagcg accacagccc cctctgtgct gacagccttg ggcaggagcc aggggctgcc   1440
 agcttccaga acgacagccc tcctcaggtg agggggctca gcagctgtga ccagaagctg   1500
 gggagcggct ggcagggtcc ccggccctgt gtgcagggag acctgcaagc agcacagctc   1560
 tgggcgggat gctggccttc tgacacagcc cttggagccc tcgagagtct tcccccaccc   1620
 acggtgggcc agagcccacg ccatcaccta cctcagcctg agggtcctcc ggatgcccgc   1680
 gagacaggac ggtgttaccc gctggacaaa ggggccgagg gctgctccgc gggagcccag   1740
 gagcctccca gggccagccg tgcagaaaaa gccagccaga ggctggcagc cagcatcacg   1800
 tgggcagatg gggagagcag caggatctgc ccgcaggaga cgcccctgtt gcactccctg   1860
 acccaggagg ggaagcgccg gcctgagagc agtccagagg acagcgccac cagaccgcca   1920
 ccgttcgacg cccacgtggg caagcccacc cgaagaagcg accgctttgc caccaccctg   1980
 cggaatgaga tccagatgca tagagccaag ctgcagaaga gccggagcac agtggctctg   2040
 actgcagcag gggaggcgga ggatggcacc ggccgctgga gggccgggtt gggaggtggc   2100
 acccaggaag gacccctcgc tggcacctat aaagaccacc tgaaagaggc ccaagcccgg   2160
 gtcctgaggg ccacgtcctt caagcgccgc gacttggacc ccaacccagg agacctatac   2220
 ccggagtcac tggaacaccg gatgggggat ccagacactg tcccccactt ctgggaggca   2280
 ggcctggccc agccaccctc atctacaagt ggcgggcccc acccgccccg catcggaggc   2340
 cggagacggt tcacagctga gcagaaattg aagtcctact cggaacctga gaagatgaac   2400
 gaggtgggcc tcacgagggg ctacagtcct caccagcacc ccaggacatc tgaggatact   2460
 gtgggcacgt ttgctgacag gtggaagttt tttgaggaaa cgagcaaacc tgttccccag   2520
 aggcctgccc agaagcaagc tcttcacgga atcccgagag acaagccaga gaggccgcgg   2580
 acagcgggcc gcacatgtga gggcacggag ccctggtcgc gcaccacctc ccttggggac   2640
 agcctcaacg ctcacagcgc agcggagaag gcagggactt cagacctgcc gcggaggctc   2700
 ggcacctttg cagagtatca ggcctcttgg aaggaacaga ggaaacctct ggaggccagg   2760
 agctctgggc gctgccactc agcggatgac atcctggatg tgagcctgga cccacaggag   2820
 aggccgcagc acgttcatgg gaggtcccgg tcttcaccgt ccacagacca ctacaagcag   2880
 gaagcttctg tcgaactgcg aaggcaggca ggggaccccg gcgagcccag agaagagctt   2940
 ccctccgcag tccgggccga ggagggacag tccacgccga gacaagcaga tgcccagtgt   3000
 cgggaaggca gcccaggatc acagcagcac ccaccgagtc agaaggcacc gaacccaccc   3060
 acattctctg aactatctca ctgccgggga gccccagagc tgccccggga gggccggggc   3120
 cgagcgggaa ccctacctcg agattataga tactcggagg agagcacccc agcagacttg   3180
 ggaccccgag cccagagccc tggctcaccc ctgcatgctc gaggacaaga ctcgtggcca   3240
 gtgagctcag ccctgctctc caagaggcca gccccacaga ggccaccgcc acccaagcgc   3300
 gagcccagga gatacagggc cacagacggc gcacctgctg acgcccccgt gggcgtcctc   3360
 ggcaggccct tcccaacgcc atcccctgcg tccctggatg tgtatgtggc ccgcctgtcc   3420
 ctctcccaca gcccctctgt gttcagcagt gcccagcccc aggacacccc gaaggccact   3480
 gtctgtgagc gtggaagcca gcatgtgagc ggggacgcat cacgtcctct gccagaagca   3540
 ctgctccctc ccaagcagca gcacctgcgc ctgcagacgg ccaccatgga gacctcgcgc   3600
 tccccctcgc cccagttcgc cccccagaaa ctgacggaca aacctcccct gctcatccag   3660
 gatgaggatt caaccaggat tgagcgggtg atggacaaca acaccacggt gaagatggtg   3720
 cccatcaaga tcgtgcactc ggagagccag ccagagaagg agagccgcca gagcctggca   3780
 tgccccgccg agccacctgc cctgccccac gggctggaga aagaccagat caagacgctg   3840
 agcacatctg agcagttcta ctcgcgcttc tgtctgtaca cgcggcaggg tgctgagccc   3900
 gaggccccac atagggccca gccggctgag ccccagcccc tgggcaccca ggtgcccccc   3960
 gagaaagacc gctgcacctc ccctccaggg ctcagctaca tgaaggccaa agagaagact   4020
 gtggaagacc tgaagtcgga ggagctggcc agggagatcg tggggaagga taagtccctg   4080
 gccgacatcc tggatcccag tgtgaagatc aaaaccacta tggacttgat ggaaggcatc   4140
 ttccccaaag acgagcacct cctggaagaa gcccagcaac ggaggaagct gctccccaaa   4200
 atcccctctc ctagaagcac agaggagagg aaagaggagc ccagcgtgcc tgcggccgtg   4260
 tccctggcca ccaattctac ctactacagc acgtcggccc ccaaggcgga gctgctgatc   4320
 aagatgaagg acctgcagga gcagcaggag cacgaagagg attcgggaag cgacttggac   4380
 cacgacctgt cggtgaagaa gcaggagctc atcgagagca tcagccgcaa gctgcaggtg   4440
 ctccgggagg cccgcgagag cctgctggag gacgtgcagg ccaacaccgt gctgggggcc   4500
 gaggtggagg ccatcgtgaa aggcgtctgc aagcccagcg agtttgacaa gttccggatg   4560
 ttcattggag acctggacaa agtggtgaac ctcctgctgt cgctgtcagg ccgcctggcc   4620
 cgggtggaga atgccctcaa taatttggac gacggcgctt ctcccggtga tcggcaatca   4680
 ctgcttgaga agcagagagt cctgatccag cagcacgagg acgccaagga gctcaaggag   4740
 aacctggacc gccgcgagcg catcgtcttt gacattttgg ccaactatct gagcgaggag   4800
 agcctcgcgg actatgagca cttcgtgaag atgaagtcgg ccctcatcat cgagcagcgg   4860
 gagctggaag ataaaatcca ccttggtgaa gagcagctga agtgcttatt ggacagcctt   4920
 cagcccgaaa ggggcaaata agagaccagt ccccggtgga ggaggggcac ggggcctccg   4980
 agctccagct ccgttcccaa ggatactcgt gaagacccca tctgtgttca tggcctggaa   5040
 agagacttct cccatagcaa agaggctgtt ataaaagcaa taacttttgt gtttgtgtgg   5100
 gatgatttat ttaatttttt agtttcccct ttgattgctg agagccattt tcctttacac   5160
 ataactacac ctgacaccag gctctgctgg atgtgagttt ccactgcatg ggctgtgggc   5220
 tgggcctgtg gtgcctgccg agtggtcact gtcagtggga aacccgttgt tcctcccgtc   5280
 ttcagatgct gagccaactg cttggacagc agccagcgcg tcatgacgtg catgagaggg   5340
 ggaccctggt gctcatcttc tcttgtcatt catccaggca tgggctgcca ggttttgtcc   5400
 ctgctcgttc aacagtgtga gcatttgtct ctgttatcta atgatgttct ctgacccagc   5460
 agaaatcatc atcatgatga tgataattta ttaacttttt ggaagggtga atagtttcct   5520
 aatggttaaa aaccaactgt gaaaggaacc acctgtgtgg ttgggttcac tcattctcag   5580
 attaaattgc cacttaaaga aataacgtgc atgctttaaa aaacacagtc acgcaccaag   5640
 caggcaaata gctttagtcc ttctcacctc acatcacagt tgttctgcaa agtaaaattt   5700
 tttggttaag agcgtgtcca gtagtaatgt gcttgttagc tgtttctcaa gaccaacaga   5760
 agattttttc agttactttc cccccatgta ttttgtatgc atatgattgt ccgtgataat   5820
 tgggctactt ttccattgtt tcctccttaa atcgtttagc atggcatgag ggccacattc   5880
 catggacggg aagaccccct tcctcttcag aggtcccgtg ggacctacac agcctccctg   5940
 agcttggatc ctttttcctg ccccatgaag ttttaaagat tcctatgccc catttccctt   6000
 gattgaaatg gcaggattcc taaagagagc cctggtttgt taaaagaaaa cactgtcatg   6060
 cctgtcagtt ccccaattga caagtcacag actgggagaa aatatttgca aatcgtgtat   6120
 ctgacaaaag gtttgtgtcc aggatgtaca aagaactctc aaaccggata gtaagaaaac   6180
 aaacagccca agtgaaaagc aggcaaaaga cttgaataga cacttcacca aagagcatac   6240
 acgcgtggca aacaagcaca cgaaaagacg ttcagccgcc gatggcttgg ttataattta   6300
 taacttactt atttttatct aataattgga gattcagtgt atttcttcaa aaaatgttta   6360
 attaaatgca tgttaatggt gagtgaatcc cttgggtgac ttcgtgttta ggtcgtatta   6420
 gggcatttgt tggatcaacg gatcatttta accctgactt ccccttattc ccataaaaga   6480
 agttttccag tggaatggag atttcatttt gtcagcagca gtgaccacag ccttaccaaa   6540
 gcagacgcgt gcgcgtgcac agatgcacac acacagatgt cttaaaagac tagaatccac   6600
 acttcctgag ccagaggggc cgtgttgacg gtaatgcatt ctctatagag ccaagtccaa   6660
 actggcaagc tcaatgatgc aggcaataaa ccgccttttt ggcagcctac caatgccaaa   6720
 aggataaatg tctttccaaa agtgtgtatt cctgttaaat taagctcttg ctaacttgaa   6780
 aaatccctgt tctgccagcg aagcttcctc ctcctctcca gctggtaggt acttgcgtga   6840
 atgctggtca gtctgaaaag gtgaagctgg ctgtgcactt acccccatct ttctccctcg   6900
 gggagacgac ccaaggaatt tcaaaatatt ttgtttggca gagcttttac ctgttattct   6960
 ttgccctcaa atacagtatt ggggtcattt tgatgatatg tgtgtaaaat gtgaataatc   7020
 caattggtgt ctgtactcag ccttttgatg tctttttagg actttctctt ctacacagca   7080
 atacgtcgtg ctcgagtatc cttgtagcaa agcacataga gccagctgtc ctgtcagttc   7140
 ccctgtttgc ctctgaaacg tctggttagt ggggacccaa agattctagt gagtcaacat   7200
 ccataactct gtatctagtt gtattattca tagaaaatca atctggtgct aatggttggc   7260
 cctggtgttg ttgggtggca gctgctcctt cgccctcttg tagtgtggct gtggagggct   7320
 ctgcctatgg ggggtggcct gtggcttgta tccttcagtc caccacagca aatgtgtgta   7380
 gatttcatgc tcgacactta ccactcacct atcaacagat catcctgctt gactggtaac   7440
 aaaataaata gtgtatcatt caaaaaaaaa a                                  7471



      <210> 2314
      <211> 3936
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> misc_feature
      <222> (1)...(3936)
      <223> n = a,t,c or g


      <400> 2314
 tttcgtggcg gcggcgcaag ggtgagggcg gccccagaac cccaggtagg tagagcaaga     60
 agatggtgtt tctgcccctc aaatggtccc ttgcaaccat gtcatttcta ctttcctcac    120
 tgttggctct cttaactgtg tccactcctt catggtgtca gagcactgaa gcatctccaa    180
 aacgtagtga tgggacacca tttccttgga ataaaatacg acttcctgag tacgtcatcc    240
 cagttcatta tgatctcttg atccatgcaa accttaccac gctgaccttc tggggaacca    300
 cgaaagtaga aatcacagcc agtcagccca ccagcaccat catcctgcat agtcaccacc    360
 tgcagatatc tagggccacc ctcaggaagg gagctggaga gaggctatcg gaagaacccc    420
 tgcaggtcct ggaacacccc cctcaggagc aaattgcact gctggctccc gagccccctc    480
 tttgtcgggc tcccgtacac agttgtcatt cactatgctg ggcaatcttt cggagacttt    540
 ccacggattt tacaaaagca cctacagaac caaggaaggg gaactgagga tactagcatc    600
 aacacaattt gaacccactg cagctagaat ggcctttccc tgctttgatg aacctgcctt    660
 caaagcaagt ttctcaatca aaattagaag agagccaagg cacctagcca tctccaatat    720
 gccattggtg aaatctgtga ctgttgctga aggactcata gaagaccatt tttgatgtcc    780
 ctgtgaagat gagcacctat ctggtggcct tcatcatttc agattttgag tctgtcagca    840
 agataaccaa gagtggagtc aaggtttctg tttatgctgt gccagacrag ataaatcaag    900
 cagattatgc actggatgct gcggtgactc ttctagaatt ttatgaggat tatttcagca    960
 taccgtatcc cctacccaaa caagatcttg ctgctattcc cgactttcag tctggtgcta   1020
 tggaaaactg gggactgaca acatatagag aatctgctct gttgtttgat gcagaaaagt   1080
 cttctgcatc aagtaagctt ggcatcacag tgactgtggc ccatgaactg gcccaccagt   1140
 ggtttgggaa cctggtcact atggaatggt ggaatgatct ttggctaaat gaaggatttg   1200
 ccaaatttat ggagtttgtg tctgtcagtg tgacccatcc tgaactgaaa gttggagatt   1260
 atttctttgg caaatgtttt gacgcaatgg aggtagatgc tttaaattcc tcacaccctg   1320
 tgtctacacc tgtggaaaat cctgctcaga tccgggagat gtttgatgat gtttcttatg   1380
 ataagggagc ttgtattctg aatatgctaa gggagtatct tagcgctgac gcatttaaaa   1440
 gtggtattgt acagtatctc cagaagcata gctataaaaa tacaaaaaac gaggacctgt   1500
 gggatagtat ggcaagtatt tgccctacag atggtgtaaa agggatggat ggcttttgct   1560
 ctagaagtca acattcatct tcatcctcac attggcatca ggaaggggtg gatgtgaaaa   1620
 ccatgatgaa cacttggaca ctgcagaggg gttttcccct aataaccatc acagtgaggg   1680
 ggaggaatgt acacatgaag caagagcact acatgaaggg ctctgacggc gccccggaca   1740
 ctgggtacct gtggcatgtt ccattgacat tcatcaccag caaatccgac atggtccatc   1800
 gatttttgct aaaaacaaaa acagatgtgc tcatcctccc agaagaggtg gaatggatca   1860
 aatttaatgt gggcatgaat ggctattaca ttgtgcatta cgaggatgat ggatgggact   1920
 ctttgactgg ccttttaaaa ggaacacaca cagcagtcag cagtaatgat cgggcgagtc   1980
 tcattaacaa tgcatttcag ctcgtcagca ttgggaagct gtccattgaa aaggccttgg   2040
 atttatccct gtacttgaaa catgaaactg aaattatgcc cgtgtttcaa ggtttgaatg   2100
 agctgattcc tatgtataag ttaatggaga aaagagatat gaatgaagtg gaaactcaat   2160
 tcaaggcctt cctcatcagg ctgctaaggg acctcattga taagcagaca tggacagacg   2220
 agggctcagt ctcagagcaa atgctgcgga gtgaactact actcctcgcc tgtgtgcaca   2280
 actatcagcc gtgcgtacag agggcagaag gctatttcag aaagtggaag gaatccaatg   2340
 gaaacttgag cctgcctgtc gacgtgacct tggcagtgtt tgctgtgggg gcccagagca   2400
 cagaaggctg ggattttctt tatagtaaat atcagttttc tttgtccagt actgagaaaa   2460
 gccaaattga atttgccctc tgcagaaccc aaaataagga aaagcttcaa tggctactag   2520
 atgaaagctt taagggagat aaaataaaaa ctcaggagtt tccacaaatt cttacactca   2580
 ttggcaggaa cccagtagga tacccactgg cctggcaatt tctgaggaaa aactggaaca   2640
 aacttgtaca aaagtttgaa cttggctcat cttccatagc ccacatggta atgggtacaa   2700
 caaatcaatt ctccacaaga acacggcttg aagaggtaaa aggattcttc agctctttga   2760
 aagaaaatgg ttctcagctc cgttgtgtcc aacagacaat tgaaaccatt gaagaaaaca   2820
 tcggttggat ggataagaat tttgataaaa tcagagtgtg gctgcaaagt gaaaagcttg   2880
 aacgtatgta aaaattcctc ccttgccagg ttcctgttat ctctaatcac caacattttg   2940
 ttgagtgtat tttcaaacta gagatggctg ttttggctcc aactggagat acttttttcc   3000
 cttcaactca ttttttgact atccctgtga aaagaatagc tgttagtttt tcatgaatgg   3060
 gctttttcat gaatgggcta tcgctaccat gtgttttgtt catcacaggt gttgccctgc   3120
 aacgtaaacc caagtgttgg gttccctgcc acagaagaat aaagtacctt attcttctca   3180
 ttttatagtt tatgcttaag cacccgtgtc caaaaccctg taccccatgt tttatcattc   3240
 ataaactggt ttcatcagtc tcctcgaaag actctgaata gtcgactact gaacaatgaa   3300
 cacctggatc tgagactaag ccggacgatg actgggttaa agctctcccg gctcacccct   3360
 ccagacccgc tgcccatccc tcttccttgc tccatgccca ggggctgact tgtaaaggcc   3420
 aagtcatcaa gctttcttgc cctttggatg ttggtcagtg gggagccgga gagctggagc   3480
 tggggtcgga ggaggtagta ggtggaggtg ttcttccctg attcccttgc gggatgcctc   3540
 gggctggcct cccctgaggg tcttagctcc gagaggggac cctcttttcc acacagcctt   3600
 ctccacctct ggattttggt aactgctccc tcctcatccc ttcaggatta gtggcctcag   3660
 tgggagtctg gcttttacta gtcctggcgg acttgtggtt tctacataat gtgctcgcac   3720
 ttttgcaaaa aatcttttta tagaaccctc ctcagataat tctgagtgag tgtcatctat   3780
 ttccctgact ggtacagtat ctcttctgaa aaagcagagt gcattcaagt ctgtaggaaa   3840
 acccttttct tagggaggtg attttttttc tctctctgct tcttatttgg cctactttaa   3900
 caatttctna actaaactag ttattggcca ttttac                             3936



      <210> 2315
      <211> 2114
      <212> DNA
      <213> Homo sapiens


      <400> 2315
 ctgcccgggc tgcgcggcgt ctgcaggcgc caccgctgcc tctttccggc tgtgaccctc     60
 ctcgccgccg ccgcttggct gcgtcctccg actccccgcg ccgccgagac caggctcccg    120
 ctccggttgc ggccgcaccg ccctccgcgg ccgccccctg gggatccagc gagcgcggtc    180
 gtccttggtg gaaggaacca tgaactggca tctccccctc ttcctcttgg cctctgtgac    240
 tctgccttcc atctgctccc acttcaatcc tctgtctctc gaggaactag gctccaacac    300
 ggggatccag gttttcaatc agattgtgaa gtcgaggcct catgacaaca tcgtgatctc    360
 tccccatggg attgcgtcgg tcctggggat gcttcagctg ggggcggacg gcaggaccaa    420
 gaagcagctc gccatggtga tgagatacgg cgtaaatgga gttggtaaaa tattaaagaa    480
 gatcaacaag gccatcgtct ccaagaagaa taaagacatt gtgacagtgg ctaacgccgt    540
 gtttgttaag aatgcctctg aaattgaagt gccttttgtt acaaggaaca aagatgtgtt    600
 ccagtgtgag gtccggaatg tgaactttga ggatccagcc tctgcctgtg attccatcaa    660
 tgcatgggtt aaaaatgaaa ccagggatat gattgacaat ctgctgtccc cagatcttat    720
 tgatggtgtg ctcaccagac tggtcctcgt caacgcagtg tatttcaagg gtctgtggaa    780
 atcacggttc caacccgaga acacaaagaa acgcactttc gtggcagccg acgggaaatc    840
 ctatcaagtg ccaatgctgg cccagctctc cgtgttccgg tgtgggtcga caagtgcccc    900
 caatgattta tggtacaact tcattgaact gccctaccac ggggaaagca tcagcatgct    960
 gattgcactg ccgactgaga gctccactcc gctgtctgcc atcatcccac acatcagcac   1020
 caagaccata gacagctgga tgagcatcat ggtgcccaag agggtgcagg tgatcctgcc   1080
 caagttcaca gctgtagcac aaacagattt gaaggagccg ctgaaagttc ttggcattac   1140
 tgacatgttt gattcatcaa aggcaaattt tgcaaaaata acaaggtcag aaaacctcca   1200
 tgtttctcat atcttgcaaa aagcaaaaat tgaagtcagt gaagatggaa ccaaagcttc   1260
 agcagcaaca actgcaattc tcattgcaag atcatcgcct ccctggttta tagtagacag   1320
 accttttctg tttttcatcc gacataatcc tacaggtgct gtgttattca tggggcagat   1380
 aaacaaaccc tgaagagtat acaaaagaaa ccatgcaaag caacgactac tttgctacga   1440
 agaaagactc ctttcctgca tctttcatag ttctgttaaa tatttttgta catcgcttct   1500
 ttttcaaaac tagttcttag gaacagactc gatgcaagtg tttctgttct gggaggtatt   1560
 ggagggaaaa aacaagcagg atggctggaa cactgtactg aggaatgaat agaaaggctt   1620
 ccagatgtct aaaagattct ttaaactact gaactgttac ctaggttaac aaccctgttg   1680
 agtatttgct gtttgtccag ttcaggaatt tttgttttgt tttgtctata tgtgcggctt   1740
 ttcagaagaa atttaatcag tgtgacagaa aaaaaaatgt tttatggtag cttttacttt   1800
 ttatgaaaaa aaaattattt gccttttaaa ttcttttccc ccatccccct ccaaagtctt   1860
 gatagcaagc gttattttgg gggtagaaac ggtgaaatct ctagcctctt tgtgtttttg   1920
 ttgttgttgt tgttgttgtt ttatataatg catgtattca ctaaaataaa atttaaaaaa   1980
 ctcctgtctt gctagacaag gttgctgttg tgcagtgtgc ctgtcactac tggtctgtac   2040
 tccttggatt tgcatttttg tattttgtac aaagtaaaaa taaactgtta tgagtagtaa   2100
 aaataaaaaa aaaa                                                     2114



      <210> 2316
      <211> 3205
      <212> DNA
      <213> Homo sapiens


      <400> 2316
 cttcaagacc gagctgccac ggccgcctcc ccgcccgccc cccattctac gcgcctgccc     60
 acaccctcct cccctccttc cagcgccttt cggtggagca ctgcggcact cagcccgagc    120
 tgccgttttc ccctcgcggg gaacgctgtg acccccccgc aggagcggcg gggcggggtg    180
 ggggggcccg ggagaagatg gcgacgccgg gaagcgaacc ccaacctttc gtcccggccc    240
 tttcggtagc tactctgcac ccacttcatc atccccacca ccaccaccac caccatcagc    300
 accacggagg aaccggcgcc cccggcgggg cgggtggtgg cggcggtggc agcgggggct    360
 tcaacctgcc cttgaaccgg ggtctggagc gcgcgcttga ggaggcggcc aactccgggg    420
 ggctgaacct gagcgccagg aaattgaagg aatttccccg taccgcagcc cccgggcatg    480
 acctctcgga cacggtgcag gcagacttat ctaaaaacag actggttgaa gttccaatgg    540
 aattgtgcca ttttgtatca ctggaaattc ttaatctgta tcacaactgt atcagagtca    600
 ttcctgaggc catcgttaat ctgcagatgc tgacttacct gaacttgagt cgaaatcagc    660
 tgtccgccct gcctgcctgc ctgtgtggtc tgcctctcaa agtcttaatc gcaagtaaca    720
 acaaacttgg atcattacca gaagagatag gtcagctcaa acagttaatg gagctggatg    780
 tcagctgcaa cgagatcaca gcgttgcccc agcagatagg tcagttgaaa tctctacgag    840
 aactgaatgt cagaagaaat taccttaaag ttttaccaca agaactagta gatcttccct    900
 tggtaaagtt tgacttttcc tgcaacaaag tgctcgtgat tccaatttgt tttagagaga    960
 tgaagcagct gcaagtgtta ctacttgaga ataaccctct gcagtctcct ccagcacaga   1020
 tttgcacaaa gggcaaagtt cacatattta agtatctgag catacaagca tgccagatta   1080
 agacagctga ctccctttat ctccacacca tggagaggcc acatttacac cagcacgtgg   1140
 aagatggcaa gaaggattct gattcgggag ttggaagtga taatggagat aagcgattat   1200
 ctgccaccga gccttctgac gaagacactg ttagcctcaa tgtgccaatg tcaaacatca   1260
 tggaagaaga acagatcatc aaggaggact cgtgccatcg ccttagcccc gttaaagggg   1320
 aatttcatca ggaatttcaa ccggagcctt cccttttggg tgacagcacc aactcaggag   1380
 aagaaagaga ccagtttact gatagagcag atggtctcca ttcggaattt atgaactata   1440
 aggcaagggc agaagactgt gaagagctgt tacggataga agaggatgtg cactggcaaa   1500
 ctgagggcat aataagttca tccaaagatc aggacatgga tatagcaatg atcgagcagc   1560
 tgagagaagc agtagatttg ctgcaagatc ccaatggatt aagcacagat attacagaga   1620
 gaagtgtttt aaacctatat cctatgggat cagcagaagc cttagaatta caagattctg   1680
 cactgaatgg tcaaatacag ctggagacat ctccggtgtg tgaggtgcaa agtgatctaa   1740
 cattacagag taacgggagc cagtattctc caaatgagat tagagagaac tcccctgcag   1800
 tctctcctac cacaaacagc acagctccat ttggcctgaa gcctcgatca gtgtttctaa   1860
 gacctcagag aaatttggaa tctatagacc cgcagtttac aatccggagg aaaatggagc   1920
 agatgagaga agagaaagag ctggtggaac aacttcgtga gagcattgag atgagattga   1980
 aggtcagtct acacgaagac ctgggggcag ccctcatgga tggtgtcgtc ctctgccatc   2040
 tggtcaacca catccgccca cggtcggttg caagcatcca tgtcccatca ccagcggttc   2100
 ccaaacttag catggccaaa tgcagaagaa atgtggaaaa ctttttggaa gcgtgccgaa   2160
 aattaggagt accagaggaa aagctatgtc tcccccacca catccttgaa gaaaaaggcc   2220
 tggtcaaagt gggcattacc attcaagcat tactagacat caccgtaacg aaggctctgt   2280
 tcacatgaaa ctaccccttc tccattgggg gctcagactc tgctctcatc caggatcctg   2340
 aactctgctc caggcacctg ttcaaccctc tctcccaccc actgcctgtc acttcactga   2400
 ctccagttac attgaaacaa ttttcagtct aagggaggat tttctacctt tcagagctga   2460
 cctccgactt taagacttga caggtattta tcttgaaacc agagagggag ctggaggaaa   2520
 aaaaaactga gcagcacatc aatgcctttt ccaccctcct tcatcctttc cacactcacc   2580
 gactgccatt accaaaacgc caagcacaac cgttttgcag caagacgcat tcgttttatt   2640
 aaaaccaaac tcattatgta tttagtgggg ggaggggggc acaatcaggt ttttcaccac   2700
 caaatttttc gagaggtttc ttgagaccat tgccttttaa aaaactattt tcgacataca   2760
 aaatatttat ataaatatta tttattagtg agttgttatt catcctttgg atgcaaattg   2820
 taaattagga aactatttta ttactgcttt tttgtggtta aacactttat tttaatataa   2880
 atgttgagtt attttctatc ctctttggtg tgcggtagtt taggtctcag taatgtttct   2940
 ggtatatatg attccaaaaa aaagcgaaaa acaggtgctt ttaggacaca acttttctgg   3000
 ggaggcaata ttgacacttt ggtttgtgga acgttggtct tatttatatt tctgcattcc   3060
 atccagtttc ctacattcca gcagccctct gtcccccaat ataatgaact gactaaaatc   3120
 aagagagcac cccaaagtta tttgtaaata gctgtgatgg aaaaaaaaaa gacatattaa   3180
 acttgaagct aaaatgtgaa caatt                                         3205



      <210> 2317
      <211> 567
      <212> DNA
      <213> Homo sapiens


      <400> 2317
 atgtccctgg gttgtttttc agaaacctgg accccaccaa atggatctgt tggcatgtac     60
 acatcagcaa tccaaatgtc agtgtttagc tttgctgcac tgggtgggca gaccgaagtt    120
 cagtttggta acatgcccag aagaggaact gttagttcaa atgagagaag ccactatagc    180
 aggtatgggg gtggtatcac agtactgaga gaggagaaag gaagaaaccg acacatagac    240
 acttgccatt gtgttcgcat tgcctacagc gttcagtaca gtaacatgct gtgcagggaa    300
 cgtgttgaga ataccagtca cccaggagag atgcaagtaa ccattcaaaa cctaatgcca    360
 gcgaccgtgt acatctttag agttatggct caaaataagc atggctcagg agagagttca    420
 gctccactgc gagtagaaac acaacctgag gctatttcag atgttttcca ctacctgcaa    480
 attctggtcc ttcccaacac caccaccctt ctctcatcat cagcagatga actcatctca    540
 tattttagag gctattcaag ccgttaa                                        567



      <210> 2318
      <211> 433
      <212> DNA
      <213> Homo sapiens


      <400> 2318
 ccagttacgg tgctggccgt cgagtctgag ttcacaccgg tgcccgcgtg gtctccagtt     60
 acggtgctgg ccgtggagtc tgggttcaca ccggtgcccg cgtggtctcc agttacggtg    120
 ctggccgtgg agtctgggtt cacaccggtg cccgcgtggt ctccagttac ggtgctggcc    180
 gtcgggtctg agttcacacc ggtgcccgca tggtctccag ttacggtgct ggccgtggag    240
 tctgggttca caccggtgcc cgcatggtct ccagttacgg tgctggctgt cgggtctgag    300
 ttcacgctgg tgcccgcgtg gtttccagtt acagtgctgg ccgcttgtac ctttctggga    360
 agttagaagg aggatcattt catcgcctcc ctgtcctccc acaccttgac ctatactggg    420
 ccaccgctgt att                                                       433



      <210> 2319
      <211> 464
      <212> DNA
      <213> Homo sapiens


      <400> 2319
 aaaacagctt tagctgttct ttatcttgtg cacatgatac aaaatatgtt cccgtacaat     60
 atggggctgt cacttcttgc caacccagca ccctcttcct cttctaacct gctttctgag    120
 gcttctgctc ttcacctcct gctcgctgat ggaaacctcc agggcaaagc tgaaggtttc    180
 ttggggaagc caggaaagcc agtatttcct atgtgtcaga tctgcttggc ttccaagaag    240
 ggatgcatgg gctttttggc cagtgtttcc aggaggctct gggcttcctg cttcttcccc    300
 gcttccccca gagttcacag atgttgaagt ttctgaaggt tgacgtcact ggaagtctga    360
 ccacaaacaa gttggctgtt actgtatttg aaacccagta cctttggcag ctcacctcta    420
 accagtaaaa taagaggatt ccatggtttc aaaaaaaaaa aaaa                     464



      <210> 2320
      <211> 6028
      <212> DNA
      <213> Homo sapiens


      <400> 2320
 gtggttctcc cagcatggag cttgagatct gagaacggac agactgcctc ctcaagtggg     60
 tccctgaccc tcaagtagcc taactgggag gcaccccaca gtaggggcag actgacacct    120
 cacacagccg ggtacccctc tgagacgaaa cttccagagg aacgatcagg cagcaacatt    180
 tgctgttcag caatatccgc tgttctgcag cctctgctgc tgatacccag gcaaacaggg    240
 tctggagtgg aactccagca aactccaaaa gacctgcagc tgagggtcct gactgttaga    300
 aggaaaacta acaaacagaa aggacatcca caccaaaacc ctatctgtac gtcaccatca    360
 tcaaagacca aaggatcaaa ttcacacata acaatattaa ccttaaatgt aaatgggcta    420
 aatgctccaa ttaaaagaca cagactggca aattggataa agagtcaaga cccatcagtg    480
 tgctgtattc aggagaccca tctcacgtgc agagacacac acaggatcaa aataaaggga    540
 tggagggaga tctaccaagc aaatggaaaa caaaaaaagg caggggttgc aatcctagtc    600
 tctgataaaa cggactttaa accaacaaag atcaaaagag acaaagaagg ccattacatg    660
 atggtaaagg gatcaattca acaagaagag ctaactaccc taaatatata tgcacccaat    720
 acaggagcac ccagattcat aaagcaagtc cttagagacc tacaaagaga cttagactcc    780
 cacacattaa taatgggaga ctttaacacc ccactgtcaa cattagacag atcaacgaga    840
 cagaaagtta acaaggatat ccaggatttg aactcagctc tgcaccaagt ggacctaata    900
 gacatctaca gaactctcca ccccaaatca acagaatata cattcttctc agcactacac    960
 cacatttatt ccaaaattga ccacatagtt ggaagtaaag cactcctcag caaatataaa   1020
 acaacagaaa ttataacaaa ctgtctctca gaccacagtg caatcaaact cgaactcagg   1080
 attaagaaac tcactcaaaa ccgctcaact acatggaaac tgaacaacct gctcctgaat   1140
 gactactggg tacataacaa aatgaaggca gaaataaata cattatttga aaccaacgag   1200
 aacaaagaca caacatacca gaatctctgg gacacattca aagcagtgtg tagaaggaaa   1260
 ttcatagcac taaatgccca caagagaaag caggaaagat ctaaaattga caccctaaca   1320
 tcacaattaa aagaactaga gaagcaagaa caaacacatt caaaagctag cagaaggcaa   1380
 gaaataacta agatcagagc aaaactgaag gaaatagaga cacaaaaaat ccttcaaaaa   1440
 aatcagtgaa tccaggagct ggttttttga aaggatcaac aaaattgata gaccgctagc   1500
 aagactaata aagaaaaaaa gagagaagaa tcaaatagac acaataaaaa atgataaagg   1560
 ggatatcacc actgatccca cagaaataca aactaccatc agagaatact acaaacacct   1620
 ctacgcaaat aaactagaaa atctagaaga aatggataaa ttcctcgaca catacactct   1680
 cccaagacta aaccaggaag aagttgaatc tctgaataga ccaataacag gagctgaaat   1740
 tgtggcaatt atcaatagct taccaccacc aacaacagca agaggcccag gaccagacgg   1800
 attcacagct aaattctacc agatgtatga aaatgaactg gtgccattcc tactgaaacg   1860
 attccaaaat attgaaaaag agggactcct ccctaactca ttctatgagg ccagaatcat   1920
 catgttagca aaagcctggc agagatacaa caaaaaaaga aaacttcagg ctaatatcct   1980
 tgatgaagat cggtgcaaaa atcctcaaga aaatactagc aaaccgaatc cagcagcaca   2040
 tcaaaaagct tatccaccat gatcaagtgg gcttcatccc tgggatggaa agctggttca   2100
 atatacgcaa atcaataaat gtaatccagc atataaacag agccaaagac aaaaaccaca   2160
 tgattatctc aatagatgca gaaaaggcct ttgacaaaat tcaacaaccc ttcatgctaa   2220
 aaactctcaa taaattaggt attgatggga cgtatttcaa aataataaga gctatctatg   2280
 acaaacccac agccaatatc atactgaatg ggcaaaaact ggaagcattc cctttgaaaa   2340
 ctggcacaag acagggatgc cctctctcac tgctcctatt caacatagtg ttggaagttc   2400
 tggccagggc aatcaggcag gagaaggaaa taaagggtat tcaattagga aaagaggaag   2460
 tcaaattggc cctgtttgca gacaacatga ttgtatattt agaaaacccc atcatctcag   2520
 cccaaaatct ccttaagctg ataagcaact tcagcaaagt ctcaggatac aaaatcaatg   2580
 tacaaaaatc acaagcattc ttatacatca ataagagaca aacagagatc caaatcatga   2640
 gtgaactccc attcacaact gcttcaaaga gaataaaata cctaggaacc caaattacaa   2700
 gggatgtgaa ggacctcttc aaggaggact acaaacaact gctcaacaaa ataaaagagg   2760
 acacaaacaa attgaagaac attccatgct catggatagg aagaatcaat atcatgagaa   2820
 tgggcagact gcccaaggta atttatagat tcaatgccat ccccatcaag ctaccaatga   2880
 ctttcctcac agaattggaa aaacactact ttaaaattca tatggaacca aaaaagagcc   2940
 cgcattgcca agtcaatcct aagccaaaag aacaaagctg gaggcatcac gctacctgac   3000
 ttcaaactat actacaaggc tacagtaacc aaaacagcat ggtactggta ccaaaagaga   3060
 gatatacatc aatggaacac aacagagccc tcagaaataa ctccgcatat ctacaaccat   3120
 ctgatctttg acaaacctga gaaaaacaag caatggggaa aggattccct atttaataaa   3180
 tggtgctggg aaaactggct agccatatgg agaaagctga aactggatcc cttccttaca   3240
 ccttatacaa aaattaattc aaggtggatt aaagacttaa atgttagacc taaaaccata   3300
 aaaaccctag aagaaaacct aggcattacc attcaggata taggcatggg caaggacttc   3360
 atgtctaaaa caccaaaagc aatggcaaca aaagccaaaa ttgacaaatg ggatctcatt   3420
 aaactaaaga gcttctgcac agcaaaagag aaactaccat cagagtgaac aggcaaccta   3480
 caaaatggga gaaaattttc acaacctact catctgacaa agggctaata tccagaatct   3540
 acaatgaact caaacaaatt tacaagaaaa aatcagacaa ccccatcaaa aagtgggtga   3600
 aggacatgaa cagacacttc tcaaaagaag acatttatgc agccaaaaaa cacatgaaaa   3660
 aatgctcacc atcactggcc atcagagaaa tgcaaatcaa aaccacaatg agataccatc   3720
 tcacaccacc tccgctgctg atacccaggc aaacagggtc tggagtggac ctctggcgaa   3780
 ctcccaacag acctgcagct gagggtcctg actgttagaa ggaaagctaa caaacagaaa   3840
 ggacatccac accaaaaccc catctttacg tcaccatcat aaaagaccaa aggctggccc   3900
 tcatgtctgc atgcagtggc tgccactgca ttaatacttt tagaggccct caaaatcaca   3960
 aactatgctc aactcactct ctacagttct cataacttcc aaaatctatt ttcttcctca   4020
 tacctgacac atatactttc tgcttcccag ctccttcagc tatactcact ctttgttgag   4080
 tctcccacaa ttaccgttgt tcctggccca gacttcaatc tggcctccca cattattcct   4140
 gataccacac ctgaccccca tgactatctc tctgatccac ctgacattca ccccatttcc   4200
 ccatatttcc ttctttcctg ttcctcaccc cgatcacgct tgatttattg atggtggttc   4260
 caccaggcct aatcgccaca caccagcaaa ggcaggctat gctatagtac aagccactag   4320
 cccgtctctt agaacctctc atttcctttc catcctggaa atctatcctc aaggagatca   4380
 cttctcagtg ttccatctgc tattctacta cccctcaggg attgttcagg ccccctccct   4440
 tccctacaca tcaagctcaa ggatttgtcc ctgcccagga ctggcaagtt gactttactc   4500
 acatgccccg agtcagaaaa cgaaagtatc tcttagtcta ggtagacact ttcactggat   4560
 aggtagaggc ctttcctgca gggtctgaga aggccaccgc agtcatttct tccattctgt   4620
 cagacataat tcctcagttt agccttccca cctcaataca gtctgataac agacgagcct   4680
 ttattagtca aatcagccaa gcagtttttc aggctcttag tattctgtga aacctttata   4740
 tcccttacgg tcctccatct tcaagaaaag tagaatggac taaaggtctt ttaaaaacac   4800
 acctcaccaa gctcagccac caacttaaaa aggactggac aatactttta ccactttccc   4860
 ttctcagaat tcaggcctgt cctcggaatg ctacagggta cagcccattt aagctcctgt   4920
 atagatgctc ctttttatta ggccccagtc tcattccaga caccagacca acttagactg   4980
 tgccccaaaa aacttgtcat ccctactatc ttctgtctag tcatactcct attcaccgtt   5040
 ctcaactact catacatgcc ctgctcttgt ttacactgct ggttacactg ccggtttaca   5100
 ctgtttctcc aagccatcac agctgatatc tcctggtgct atccccaaac tgccactctt   5160
 aactcttgaa gtaaataaat aatctttgct ggcaggacta tgctgaatct ccttaggcac   5220
 tctctaatca gatgtcctag gtcctcccaa ttcttagacc ttttatacct gtttttctcc   5280
 ttctcttatt ccatttagtt tttcaattca tacaaaaccg tatccaggcc atcaccaatc   5340
 attctaaatg acaaatgttt ctgctaatag tcccacaata tcacccctta ccacaaaatc   5400
 ttccttcagc ttaatctctc ccactctagg ttcccacgcc gcccctaatc ccactcgaag   5460
 cagccctgag aaacatcgcc cattctctct cccctaccac ccctcaaaaa ttttcgccac   5520
 cccaacactt taccactatt ttgttttatt tttcttatta acataagaag acaggaatgt   5580
 caggcctctg agcccaagct aagccatcat atgcccagtg acctgcacgt atacatccag   5640
 atggcctgaa gcaactgaag atccacaaaa gaagagaaaa tagccagttc ctgccttaac   5700
 tgatgacatt ccaccacaaa agaagtgaaa atgctctgtt cctgccttaa ccgatgacat   5760
 tatcttgtga aattccttct cctggctcat cctggctcaa aagctcccct actgagcacc   5820
 ttgtgacccc tccactcctg cctgccagag aacaaccccc ctttgactgt aattttcctt   5880
 tacctaccca aatcctataa aatggcccca cccgtatctc ccttcgctca ctctcttttc   5940
 agactcagcc tgcctgcacc catgtgaaat aaacagcctc gttgctcaaa aaaaaaaaaa   6000
 atataagaaa aaaacccccc gcccctcg                                      6028



      <210> 2321
      <211> 11178
      <212> DNA
      <213> Homo sapiens


      <400> 2321
 gcacgagact gcgctcgcct ccctcctcac gcgggcggga ttttcttgcc ttgtgaaaaa     60
 ccgtctcggc ggctgccccc gcctcctctg ctggcatgtg aaatggcggt cggcgagtgg    120
 tttgcgtccg tgacatcatc atcatggcaa caagagctgc agcctgggac cgaggagccc    180
 gtgtgattcc cggcggtggc gcagtggcgg cagcaccagc accgacgaaa gcttcgaggg    240
 cttctctcct tgcggcccct tgccgggtgc tcctgaggag gcggcggcag cagcgcctac    300
 accgccccgc ccgccgttcc tcgaggtgcc tctgtgtgag gggagggggc cgtgccgaga    360
 aggggagggg gcgccgccgc cgctgcggag ggagccgccg ccgctgctgc tgccgctgcc    420
 gggtcgccag tgaagggagg cagtggcggc ggcggcgaac atgttttcag taaggatagt    480
 gactgcagac taatacatgg ccagcccgct gcaggggctg gatacctgcc aatcccccct    540
 cacccaggcc cctgtcaaga aggtgccggt ggtgcgagtc ttcggagcga ccccggcaga    600
 ataaaaccca agacaagcca cataaaagca acctaaaaat taaactgtca tcatattatt    660
 tgttttaaaa ctatggaata atatatctga ggaagatttc tctcaaaatt gtttttctca    720
 atttcaagtc agaagacatg tcttcatcta catggcatct ttccttacct ctatgtgcca    780
 tacgatggtt atggacagca gccagaaagc tatctttctc agatggcatt cagtatcgac    840
 agagcactta atgtggcttt aggcaatcca tcttccactg ctcagcatgt gttcaaagtg    900
 tcattagtat caggaatgcc tttttatggt tatcatgaga aggaaagaca ctttatgaag    960
 atctatcttt acaatcctac aatggtgaaa aggatatgtg aacttttgca aagcggagcc   1020
 ataatgaata aattttacca gcctcatgaa gcgcatattc cctacctcct acagctcttc   1080
 attgactaca atctttatgg catgaattta ataaatctgg ctgctgtcaa gttccgaaaa   1140
 gcaagaagga aaagtaatac attgcatgca actggatcct gcaagaatca tttatcagga   1200
 aattctcttg ctgatacttt atttcggtgg gaacaagatg aaataccaag ctctttaata   1260
 ttggaaggtg ttgaaccaca cagtacatgt gaattacaag tggatgctgt agctgctgat   1320
 atcttaaatc gtctggacat tgaagctcaa attggtggaa accctggtct acaggccata   1380
 tgggaagatg aaaagcaacg gcgaagaaac agaaatgaaa cttctcaaat gagccaacct   1440
 gagtcacaag atcacaggtt tgtgccagca acagaaagtg aaaaaaaatt tcagaagaga   1500
 cttcaggaaa ttctcaaaca gaatgatttc tctgtaacat tatcaggatc tgtggactac   1560
 agcgatggat cccaggagtt ctctgctgag ttaacattgc actctgaggt tctgtctcct   1620
 gaaatgcttc agtgtacacc agccaatatg gtagaagttc acaaagacaa agagtcaagc   1680
 aaaggtcaca ctagacacaa agtggaagaa gctcttatta atgaagaagc aattttgaac   1740
 cttatggaaa atagtcagac ttttcagcct ttgacccaaa gactgagtga gtcacctgtt   1800
 ttcatggaca gtagtcctga tgaggctctg gtacatcttc ttgctggttt ggaaagtgat   1860
 ggatatcggg gggaaagaaa taggatgcca tcaccatgtc gctcctttgg aaataataaa   1920
 tatccacaaa atagtgatga tgaagaaaat gaaccacaga ttgaaaaaga ggaaatggag   1980
 cttagtttgg tgatgtccca gagatgggac agcaatattg aagaacattg tgccaaaaag   2040
 agatcactgt gcagaaatac ccacagaagt tcaactgaag atgatgactc atcttcagga   2100
 gaagaaatgg aatggagtga taacagtttg cttctagcca gtctttctat acctcagtta   2160
 gatggaactg cagatgaaaa tagtgacaat ccattgaaca atgaaaattc tagaacccac   2220
 tcttctgtaa ttgcaacaag caagctttca gttaaaccct ccatctttca caaagatgct   2280
 gctacattag aaccctcatc ttctgctaag attacctttc agtgtaaaca cacaagtgcc   2340
 ctttcttccc atgttttgaa caaggaagat ttaattgaag acctttcaca gacaaacaaa   2400
 aatacagaaa aaggtctaga taactcagtc acttctttta caaacgaaag cacttattct   2460
 atgaaatacc ctggatcttt aagcagtact gttcattcag aaaattctca taaagagaat   2520
 agtaagaaag agatcctccc agtatcttcc tgtgaaagta gtatttttga ttatgaagaa   2580
 gatattccat ctgttacaag acaagtacca agtagaaaat atacaaacat tagaaaaatc   2640
 gaaaaggatt ccccttttat acatatgcac cgtcacccta acgagaatac attgggcaaa   2700
 aattctttca acttttctga cttaaatcat tcaaaaaata aagtatcctc tgaaggaaat   2760
 gaaaaaggaa acagcacagc tctgagtagt ttattccctt catcatttac tgaaaattgt   2820
 gaattactgt catgctcagg ggagaataga actatggtgc attctcttaa tagcactgct   2880
 gatgaaagtg gactaaataa acttaaaatt aggtatgaag aatttcaaga acataaaaca   2940
 gaaaagccaa gcctcagcca gcaagcagca cactatatgt tttttcccag tgttgttctt   3000
 tctaactgtc ttactagacc acagaaacta tctcctgtca catataaatt acaacctggc   3060
 aataaaccat cccggttaaa attgaataaa aggaaacttg caggtcatca ggagacttct   3120
 accaaaagta gtgagactgg atccacaaaa gataatttta tacaaaataa tccttgtaat   3180
 agtaatcctg agaaggataa tgcattggct agtgatttaa ctaaaaccac tcgtggagct   3240
 tttgaaaata aaacacccac agatggtttt atagactgtc actttggaga tggaacgtta   3300
 gaaactgagc agtcctttgg actatatgga aataaataca cacttagagc caaacgcaag   3360
 gtaaattatg agactgaaga cagtgagtca agttttgtaa ctcacaactc aaaaattagt   3420
 ctacctcatc ccatggaaat tggtgaaagt ttagatggaa ctctcaaatc ccgaaaacga   3480
 agaaaaatgt ctaaaaagct gccccctgtc atcataaagt atattattat taatagattt   3540
 agagggagaa aaaatatgct tgtgaagcta ggaaaaatag actctaaaga aaaacaagta   3600
 atattaacag aagaaaaaat ggaactatat aaaaagcttg cacctttgaa ggacttttgg   3660
 ccaaaagttc ccgactcccc tgcaaccaaa tatcccattt atccactaac accaaagaaa   3720
 agtcacagaa gaaagtcaaa acataaatct gctaagaaaa aaactggtaa acaacaaagg   3780
 acaaataatg aaaatattaa aagaactttg tctttcagga aaaaacggtc acatgctatt   3840
 ctttctcctc cctcaccatc ttacaatgct gaaaccgaag attgtgactt gaattatagt   3900
 gatgttatgt ctaaactagg ttttctttct gagagaagca caagtcccat aaattcttct   3960
 ccacctcgct gctggtctcc cacagatcca agagctgaag aaatcatggc tgctgcagaa   4020
 aaagaggcaa tgctttttaa gggtcctaat gtatgtaaga agactgttaa ttctcgtata   4080
 ggaaaaacta gtcgcgcaag agcacagatt aagaaatcaa aagcaaagct tgctaatccc   4140
 tctatagtta ctaagaaaag gaacaaacga aatcagacaa ataaactagt agatgatgga   4200
 aaaaagaaac caagagcaaa acaaaaaaca aatgagaaag gtacatcgag aaagcatata   4260
 acacttaagg atgaaaaaat aaaatctcag tctggtgctg aggttaagtt tgtactgaaa   4320
 caccagaatg tgtctgaatt tgcaagtagt tctggaggct ctcaactact ttttaaacag   4380
 aaagatatgc cactaatggg ctctgctgta gatcatcccc tttctgcttc cctacccact   4440
 ggaattaatg cacaacagaa gttatctggc tgcttttctt ctttcttaga aagcaagaag   4500
 tctgtagatt tgcagacatt ccccagttca cgagatgatt tgcatccatc agttgtttgt   4560
 aattctatag gacctggagt ctcaaaaatt aatgttcaaa ggcctcataa tcaaagtgct   4620
 atgtttactc taaaggaatc aacgttaatt caaaaaaata tatttgacct ttccaatcat   4680
 ttatctcagg tagcacagaa tacacagata tcttctggta tgtcctcaaa gatagaagat   4740
 aatgcaaata atatacaaag aaactatttg tcatcaatcg gaaagttaag tgaatatcgc   4800
 aattccctag aatcaaagct ggaccaagca tataccccta attttttgca ttgcaaagac   4860
 agtcagcagc agattgtgtg catagcggaa cagtcaaagc acagtgaaac ttgttctccg   4920
 ggaaatacag cttcagagga aagccaaatg cctaataatt gctttgtaac ttccttgaga   4980
 agtccaatca aacaaatagc atgggagcaa aagcaaaggg gctttatttt agatatgtca   5040
 aattttaaac ctgaaagagt aaaaccgagg tcattatcag aagcaatttc acaaaccaaa   5100
 gcactttctc agtgtaaaaa tcgaaatgtg tcaacacctt cagcatttgg tgaaggacag   5160
 tctggactgg cagttctaaa agaattgtta caaaaaagac agcaggaagc acaaaatgca   5220
 aatactacac aagacccatt atccaataaa catcaaccaa ataaaaatat ttctggttcc   5280
 cttgagcata acaaagcaaa taaacggaca cgatcggtaa cgtccccaag aaaacctcga   5340
 actcccagaa gtacaaaaca aaaagaaaaa atccccaaac ttctcaaagt agactcttta   5400
 aatttacaaa actctagcca gttggataac tctgtatcag atgatagtcc catctttttt   5460
 tcagatccag gctttgaaag ttgttactca cttgaagata gtttatctcc tgaacataat   5520
 tataattttg atattaacac aataggtcag actggatttt gtagctttta ttctggaagt   5580
 cagtttgtcc cagctgatca gaatttgcct cagaagttcc taagtgatgc tgttcaggat   5640
 ctttttccag gacaagctat agaaaaaaat gagtttttaa gtcatgacaa ccagaaatgt   5700
 gatgaagaca agcatcatac cacagactca gcctcatgga ttagatctgg tactttaagt   5760
 cctgaaattt ttgagaagtc aaccatagat agcaatgaga atcgtcgcca caaccagtgg   5820
 aaaaatagct ttcatcctct aacaactcgg tctaactcaa taatggattc tttctgtgtt   5880
 cagcaggcag aagactgtct aagtgaaaaa tctagattga ataggagttc agtaagcaaa   5940
 gaagtgtttc ttagcctccc acagccaaac aattcagact ggattcaagg tcacaccaga   6000
 aaagaaatgg gacagtctct tgactcagcc aatacctctt ttactgcaat actctcctcc   6060
 cctgatggtg aacttgtaga cgtggcctgt gaagatttag aactgtatgt ttcaagaaac   6120
 aatgatatgt tgacaccaac tcctgatagt tcaccaagat ctactagctc tccttcacaa   6180
 tctaaaaatg gcagcttcac ccctcgaact gctaacattc tgaaaccact tatgtccccc   6240
 ccaagtaggg aagaaattat ggcaactttg ttggatcatg acctgtctga gactatttac   6300
 caggaaccat tttgcagtaa tccttctgat gtaccagaaa agcccaggga gattggtgga   6360
 cggctcctca tggtagaaac tcgacttgca aatgatctgg ctgagtttga gggagacttt   6420
 tccttggaag gacttcgtct ttggaaaaca gcattctcag caatgactca gaatccaagg   6480
 ccagggtcac cccttcgcag tggccaagga gttgtcaata aagggtcaag taatagccct   6540
 aagatggttg aagataaaaa aattgtgatt atgccttgca aatgtgcccc aagtcgacaa   6600
 ctggttcaag tgtggcttca agccaaagaa gaatacgaac gttccaagaa actgcctaaa   6660
 accaagccaa ctggagttgt aaaatctgct gagaacttta gctcttcagt taacccagat   6720
 gacaaacctg tagtgcctcc aaaaatggat gtaagtccat gtatactccc cactacagca   6780
 cataccaagg aggatgttga taattctcag attgctttac aagcaccaac cacgggatgt   6840
 agtcaaactg caagtgaaag tcagatgctg ccaccagttg cctctgcaag tgatcccgaa   6900
 aaagatgaag atgatgatga taactattac attagttata gctcccctga ttctccagta   6960
 attccccctt ggcaacaacc aatatcccca gattccaaag cattaaatgg agatgataga   7020
 ccctcatcac cagtagagga gctgccttca ttggcttttg agaacttctt aaagccaata   7080
 aaagatggta tacaaaaaag cccctgcagt gagcctcaag agcctctagt gatatctcca   7140
 attaatacta gggcaagaac tgggaaatgt gaatcacttt gctttcatag tacaccaatc   7200
 atacagagaa aacttctgga aaggcttcct gaagcacctg gccttagccc attatcaaca   7260
 gaaccaaaaa cacagaagtt gagtaataag aaaggaagta atactgacac tcttagaaga   7320
 gtactgttaa cacaagcaaa gaatcaattt gcagcagtaa ataccccaca gaaagaaact   7380
 tctcagattg atggaccatc tttaaacaat acttacggtt tcaaagtcag catacaaaac   7440
 ttacaggagg caaaagcttt acatgagata caaaatctta ccctaatcag tgtggagttg   7500
 catgctcgaa ctagacgaga cttagaaccg gatcctgaat ttgacccaat ctgtgctctg   7560
 ttctactgca tctcatctga cactccactg ccagatacag aaaaaacaga actcacaggt   7620
 gtaatagtga ttgataaaga caagacagtt ttcagtcaag atatcagata tcagactcca   7680
 ttacttatta gatctggaat tacaggactc gaagtcacct atgctgctga tgagaaggca   7740
 ctttttcatg aaattgcaaa tataataaag aggtatgatc ctgatattct gctaggatat   7800
 gagattcaga tgcattcctg gggttacctc ttacaaaggg ctgccgcttt aagtattgac   7860
 ttatgtcgga tgatctctcg ggtgccagat gacaaaattg agaacagatt tgcagctgaa   7920
 agagatgagt atggatcata tacaatgagt gagataaata ttgttggccg aattacacta   7980
 aatctttgga gaatcatgag aaatgaggtg gctctaacta actacacctt tgaaaatgtg   8040
 agctttcatg ttcttcatca gcgttttccc ctctttacct ttcgagtctt gtcagactgg   8100
 tttgataaca agacagatct atacagatgg aaaatggttg atcattatgt tagccgtgtc   8160
 cgtggaaatc tccaaatgtt agaacagctg gacctgattg ggaaaaccag tgagatggct   8220
 agactttttg gcattcagtt tttacatgta ctgacaaggg gttcacagta ccgtgtggaa   8280
 tcaatgatgt tgcgtattgc taaaccaatg aactatattc ctgtgacacc tagtgttcag   8340
 caaagatccc agatgagagc cccacagtgt gttcctctaa ttatggagcc tgaatcccgc   8400
 ttctatagca actctgttct cgttttggat ttccaatcac tttatccttc tattgtgatt   8460
 gcatataact actgcttttc cacctgcctt ggccatgtgg agaacttggg aaagtatgat   8520
 gagttcaaat ttggctgtac ctctctgaga gtacctccag atttacttta ccaagttagg   8580
 catgatatca cagtgtcccc caatggagta gcttttgtca agccttcagt aagaaaaggt   8640
 gtactaccaa gaatgcttga agaaattttg aagactagat ttatggtgaa gcagtcaatg   8700
 aaggcttaca agcaagacag agccctgtca cgaatgcttg atgcgcgtca gttgggactt   8760
 aagctgatag caaatgtcac atttggctat acatctgcta atttttctgg gagaatgcca   8820
 tgcattgagg ttggcgatag tattgttcac aaagccagag agaccttgga acgagctatt   8880
 aaactggtga atgataccaa gaaatggggg gctagggttg tatatggcga tactgacagt   8940
 atgtttgtgc tactgaaagg agccactaag gagcagtctt ttaagattgg tcaggaaatt   9000
 gccgaagctg taactgctac caatcctaaa ccagtgaaat tgaagtttga aaaggtatat   9060
 ttgccctgtg ttttacaaac aaaaaagagg tatgtgggtt acatgtatga aacactggat   9120
 cagaaggacc cagtatttga tgcaaaagga atagaaacag tcagaagaga ttcctgccct   9180
 gctgtttcta agatacttga gcgttctcta aagctgctat ttgaaacgag agatataagt   9240
 ctaattaaac agtatgttca gcgacaatgt atgaagcttc tggaaggaaa ggccagcata   9300
 caagacttta tctttgccaa ggaatacaga ggaagttttt cttataaacc aggagcttgt   9360
 gtgccagccc ttgaacttac aaggaaaatg ctgacttatg accggcgctc tgagcctcag   9420
 gttggggagc gagtgccata cgtcatcatt tatgggaccc ccggagtacc acttatccag   9480
 cttgtaaggc gcccagtgga agtcctgcag gacccaactc tgagactgaa tgctacttac   9540
 tatattacca agcaaatcct tccacccttg gcaagaatct tctcacttat tggtattgat   9600
 gtcttcagct gggtatcatg aattaccaag gggatttatt gcggcactat tcacaatagc   9660
 aaagacttgg aaccaaccca aatgtccatc aatgatagac tggattaaga aaatgtggca   9720
 catatacacc atggaatact atgcagccat aaaaaaggat gagttcatgt cctttgcagg   9780
 gacatggatg aagctggaaa ccatcattct cagcaaacta tcacaaggac agaaaaccaa   9840
 acaccgcctg ttctcactca tagatccata aagctaccag cccctcgcga agtgaacctg   9900
 aagggcggaa aggcactatt tcacaatatt ttactacctt acactgtcct gtgtgtgatg   9960
 acctaactca gcatggcatc tgtagtaaat gtcggagcca acctcagcat gttgcagtca  10020
 tcctcaacca agaaatccgg gagttggaac gtcaacagga gcaacttgta aagatatgca  10080
 agaactgtac aggttgcttt gatcgacaca tcccatgtgt ttctctgaac tgcccagtac  10140
 ttttcaaact ctcccgagta aatagagaat tgtccaaggc accatatctc cggcagttat  10200
 tagaccagtt ttaaattgtc aatatcacag tattacaggt gctatttttt tcagtgctta  10260
 ccactaaact gttgtgcatg gtgcttttta actttcaacg agtcaaggat gttcactgtc  10320
 tgttatctga agactatgaa gacttctatg ctaaccgaat taaaatgtac ttgttgatct  10380
 ctgaatagct cacttcttac aatgtacaaa ttcctcattc tgtcaccttt taaacattgt  10440
 tttataatgc aggtgttgga tttgctccag tatgtgtacc atcttgtaaa ttcatttgag  10500
 tagatcatgt ttacttccca gtggaaggag cactgaaaac ctcttaaaga aaaagcattt  10560
 gtgtgttttc cttgaactgt ctgtatcaag acgtgttact tcgagatatc cattcacttt  10620
 ataattttga ctgcaaaata ttttgtaaat acactttttt acttttcaaa cgagcaaaat  10680
 aatgtgcaat gatttttata caaatgattt tcaagttgtt tggtatattt cctctaggtt  10740
 ttgcttgact caaagtagat cgttattttg atcaaactgt gcaaacagta gtaccacgtg  10800
 tagcattttg aaacattatt tttttttaaa aaatgctgtc ttgctttagc tattaatggg  10860
 gcattgtgag gaactgtgca aagacatttt tgttacaaac ctgtgggcct gttgcaatac  10920
 tttaaaaata aaaaatttta ttccatttgc ttgttttgta tagacatttc tattgcttct  10980
 aaatatactt aaaatatttt ctttccttat gtactgtaca gttaatctta tttgccatca  11040
 tcttgaacac aaaatgtgta tttagaatat ttgtataact gtgtaaaata aaaaaggaat  11100
 tatgtggtca gtgcattgtt ttttaaactg gaaatcattt tgttttaaaa gttaataatg  11160
 gaaaccatat taaaattg                                                11178



      <210> 2322
      <211> 740
      <212> DNA
      <213> Homo sapiens


      <400> 2322
 tctcctggat tgactttgac atctgggtcc tgacagcaac acctccccat tttaaaacaa     60
 ggttacatgc ttctgatgtg ggattccggt tcacaatgga tgctgataaa gagaaagatt    120
 tgcagaaatt tcttaaaaat gtggatgaaa tctccctaaa agaaaaaggg aatgaagcat    180
 ttgctgaagg caattatgaa acagctatcc tgcgctacag tgagggtttg gagaagctga    240
 aggacatgaa agtgctgtac accaaccgag cccaggctta tatgaaactt gaggactatg    300
 agaaggcact ggtggattgt gagtgggctc tcaagtgtga tgaaaaatgc acaaaagcat    360
 attttcacat gggaaaagcc aacctggccc tgaagaacta cagtgtgtct agagagtgtt    420
 ataagaagat cttagaaata aaccccaagc tgcaaaccca ggtgaaagtt tacctgaatc    480
 aagtagatct tcaggaaaaa gcagaccttc aagaaaagga agcccacgaa ctgctggatt    540
 caggaaagaa cacagccgtg accaccaaga acctcctgga gaccctttcc aagcctgacc    600
 agatcccctt gttctatgct ggggggattg agatcctgac tgaaatgata aatgagtgta    660
 agccagagat gtgtgtgatc tcatgagtgc tgtcagtgtg aagggacaca ttcagaggtc    720
 atagccttta ccaggccaag                                                740



      <210> 2323
      <211> 4260
      <212> DNA
      <213> Homo sapiens


      <400> 2323
 gccggcttca atcacgggtt caactgcgca gaatctacca acttcgccac cctgcggtgg     60
 attgactacg gcaaagtggc cactcagtgc acgtgccgga aggacatggt caagatctcc    120
 atggacgtgt tcgtgcgcat cctgcagccc gagcgctacg agctgtggaa gcagggcaag    180
 gacctcacgg tgctggacca cacgcggccc acggcgctca ccagccccga gctgagctcc    240
 tggagtgcgt cccgggcctc gctgaaggcc aagctcctcc gcaggtctca ccggaaacgg    300
 agccagccca agaagccgaa gcccgaagac cccaagttcc ctggggaggg tacggctggg    360
 gcagcgctcc tagaggaggc tgggggcagc gtgaaggagg aggctgggcc ggaggttgac    420
 cccgaggagg aggaggagga gccgcagcca ctgccacacg gccgggaggc cgagggcgca    480
 gaagaggacg ggaggggcaa gctgcggcca accaaggcca agagcgagcg gaagaagaag    540
 agcttcggcc tgctgccccc acagctgccg cccccgcctg ctcacttccc ctcagaggag    600
 gcgctgtggc tgccatcccc actggagccc ccggtgctgg gcccaggccc tgcagccatg    660
 gaggagagcc ccctgccggc accccttaat gtcgtgcccc ctgaggtgcc cagtgaggag    720
 ctagaggcca agcctcggcc catcatcccc atgctgtacg tggtgccgcg gccgggcaag    780
 gcagccttca accaggagca cgtgtcctgc cagcaggcct ttgagcactt tgcccagaag    840
 ggtccgacct ggaaggaacc agtttccccc atggagctga cggggccaga ggacggtgca    900
 gccagcagtg gggcaggtcg catggagacc aaagcccggg ccggagaggg gcaggcaccg    960
 tccacatttt ccaaattgaa gatggagatc aagaagagcc ggcgccatcc cctgggccgg   1020
 ccgcccaccc ggtccccact gtcggtggtg aagcaggagg cctcaagtga cgaggaggca   1080
 tcccctttct ccggggagga agatgtgagt gacccggacg ccttgaggcc gctgctgtct   1140
 ctgcagtgga agaacagggc ggccagcttc caggccgaga ggaagttcaa cgcagcggct   1200
 gcgcgcacgg agccctactg cgccatctgc acgctcttct acccctactg ccaggcccta   1260
 cagactgaga aggaggcacc catagcctcc ctcggagagg gctgcccggc cacattaccc   1320
 tccaaaagcc gtcagaagac ccgaccgctc atccctgaga tgtgcttcac ctctggcggt   1380
 gagaacacgg agccgctgcc tgccaactcc tacatcggcg acgacgggac cagccccctg   1440
 atcgcctgcg gcaagtgctg cctgcaggtc catgccagtt gctatggcat ccgtcccgag   1500
 ctggtcaatg aaggctggac gtgttcccgg tgcgcggccc acgcctggac tgcggagtgc   1560
 tgcctgtgca acctgcgagg aggtgcgctg cagatgacca ccgataggag gtggatccac   1620
 gtgatctgtg ccatcgcagt ccccgaggcg cgcttcctga acgtgattga gcgccaccct   1680
 gtggacatca gcgccatccc cgagcagcgg tggaagctga aatgcgtgta ctgccggaag   1740
 cggatgaaga aggtgtcagg tgcctgtatc cagtgctcct acgagcactg ctccacgtcc   1800
 ttccacgtga cctgcgccca cgccgcaggc gtgctcatgg agccggacga ctggccctat   1860
 gtggtctcca tcacctgcct caagcacaag tcggggggtc acgctgtcca actcctgagg   1920
 gccgtgtccc taggccaggt ggtcatcacc aagaaccgca acgggctgta ctaccgctgt   1980
 cgcgtcatcg gtgccgcctc gcagacctgc tacgaagtga acttcgacga tggctcctac   2040
 agcgacaacc tgtaccctga gagcatcacg agtagggact gtgtccagct gggaccccct   2100
 tccgaggggg agctggtgga gctccggtgg actgacggca acctctacaa ggccaagttc   2160
 atctcctccg tcaccagcca catctaccag gtggagtttg aggacgggtc ccagctgacg   2220
 gtgaagcgtg gggacatctt caccctggag gaggagctgc ccaagagggt ccgctctcgg   2280
 ctgtcactga gcacgggggc accgcaggag cccgccttct cgggggagga ggccaaggcc   2340
 gccaagcgcc cgcgtgtggg caccccgctt gccacggagg actccgggcg gagccaggac   2400
 tacgtggcct tcgtggagag cctcctgcag gtgcagggcc ggcccggagc ccccttctag   2460
 gacagctggc cgctcaggcg accctcagcc cggcggggag gccatggcat gccccgggcg   2520
 ttcgcttgct gtgaattcct gtcctcgtgt ccccgacccc cgagagggcc acctccaagc   2580
 cgcgggtgcc ccctagggcg acaggagccc agcgggacgc cgcacgcggc cccagactca   2640
 gggagcaggg ccaggcgggc tcgggggccg gccaggggag caccccactc aactactcag   2700
 aattttaaac catgtaagct ctcttcttct cgaaaaggtg ctactgcaat gccctactga   2760
 gcaacctttg agattgtcac ttctgtacat aaaccacctt tgtgaggctc tttctataaa   2820
 tacatattgt ttaaaaaaaa gcaagaaaaa aaggaaaaca aaggaaaata tccccaaagt   2880
 tgttttctag atttgtggct ttaagaaaaa caaaacaaaa caaacacatt gtttttctca   2940
 gaaccaggat tctctgagag gtcagagcat ctcgctgttt ttttgttgtt gttttaaaat   3000
 attatgattt ggctacagac caggcaggga aagagacccg gtaattggag ggtgagcctc   3060
 gggggggagg ggcaggacgc cccggtttcg gcacagcccg gtcactcacg gcctcgctct   3120
 cgcctcaccc cggctcctgg gctttgatgg tctggtgcca gtgcctgtgc ccactctgtg   3180
 cctgctggga ggaggcccag gctctctggt ggccgcccct gtgcacctgg ccaggggaag   3240
 cccgggggtc tggggcctcc ctccgtctgc gcccaccttt gcagaataaa ctctctcctg   3300
 gggtttgtct atctttgttt ctctcacctg agagaaacgc aggtgttcca gaggcttcct   3360
 tgcagacaaa gcacccctgc acctcctatg gctcaggatg agggaggccc ccaggccctt   3420
 ctggttggta gtgagtgtgg acagcttccc agctcttcgg gtacaaccct gagcaggtcg   3480
 ggggacacag ggccgaggca ggccttcggg gcccctttcg cctgcttccg ggcagggacg   3540
 aggcctggtg tcctcgctcc acccacccac gctgctgtca cctgagggga atctgcttct   3600
 taggagtggg ttgagctgat agagaaaaaa cggccttcag cccaggctgg gaagcgcctt   3660
 ctccaggtgc ctctccctca ccagctctgc acccctctgg ggagccttcc ccaccttagc   3720
 tgtctcctgc cccagggagg gatggaggag ataatttgct tatattaaaa acaaaaaatg   3780
 gctgaggcag gagtttggga ccagcctggg ctatatagca agaccccatc actacaaatt   3840
 ttttacaaat tagctaggtg tggtggtgcg cacctgtggt cccagctact cgggaggctg   3900
 tggtgggagg attgcttgag tccaggaggt tgaggctgca gtcagctcag attgcaccac   3960
 tgcactccag cctgggcaac agagcgagac cctgtctcca aaaaaaaaaa aaagccaggg   4020
 tttattttaa aaaggggggc tcaaacgccc ccgggcttgg ggggccctgg ggaaccccag   4080
 agggggtccc ccaggaccaa cccttttttt ttttttgggg gggggggggg gggcctgccg   4140
 tacaaggagc tggccaggat aaggcaggag gatcacataa aataaggggg tcgaggttta   4200
 agcgagaaac caatgcccgg agggccctcc aaaccttggt ttactcaagt ggccacctcg   4260



      <210> 2324
      <211> 392
      <212> DNA
      <213> Homo sapiens


      <400> 2324
 gagtctgggc agtctctgcc tccaccccag ctctctggcc cgagcaaagg agctggtatt     60
 cctcatctgg gcaccccggg cccccgcccg ccttcctgtc ctgccagcag gaccgctccc    120
 accacgagcc agcccagagg acgtggcagt cccacagcct ctgcacttgg cgctctggca    180
 gccctgcctg gccagaccca cgctgtctgt agcccctgaa ttcctggcct cctgtgagca    240
 gcgttggtgg gaggtggaag actcccccag ggatccacca accagccggg caggtccact    300
 tggggccagt ttctacctcg gaaaatcctg gcttcctcag cgccgacccc cagcagccct    360
 ggcctcctcc cctgctcact gctgactgct tg                                  392



      <210> 2325
      <211> 2265
      <212> DNA
      <213> Homo sapiens


      <400> 2325
 atgggagact ttaacacccc actgtcaaca ttagacagat caacgagaca gaaagtcaac     60
 aaggataccc aggaattgaa ctcagctctg caccaagcag acctaataga catctacaga    120
 actctccacc ccaaatcaac agaatataca tttttttcag caccacacca cacctgctcc    180
 aaaactgacc acatagttgg aaaaaagcaa gagcaaacac attcaaaagc tagcagaagg    240
 caagaaataa ctaaaatcag agcagaactg aaggaaatag agacacaaaa aacccttcaa    300
 aaaattaatg aatccaggag ctggtttttt gaaaggatca acaaaattga tagaccgcta    360
 gcaagactaa taaagaagaa aagagagaag aatcaaatag acgcaataaa aaatgataaa    420
 ggggatatca ctaccagtcc cacagaaata caaacaacca tcagagaata ctacaaacac    480
 ctctacgcaa ataaactaga agatctagaa gaactggata aattcctcga aacatacacc    540
 ctcccaagac taaaccagga agaaggtgac tctctgaata gaccaataac aggatctgaa    600
 attgtggcaa taatcaatag cttgccaacc aaaaagagtc caggaccaga tggattcaca    660
 gccgaattct accagaggta caaggaggaa ctggtaccat tccttctgaa acgattccaa    720
 tcaatagaaa aagagggaat cctccctaac tcattttatg aggccaacat catcctgata    780
 ccaaagtcgg ccagagacac aaccaaaaaa gataatttta ggccaatatc cttgatgaac    840
 cttgatgcaa aagcctcaat aaaatactgg caaaccgaat ccagcagcat atcaaaaagc    900
 ttatccacca tgatcaagtg ggcttcatcc ctgggatgca aggctgtgtt ggaagttctg    960
 gccagggcaa ttaggcagga gaaggaaata aagggtattc aattaggaaa agaggaagtc   1020
 aaattgtccc tgtttgcaga tgacatgatt gtatatctag aaaaccccat tgtctcagcc   1080
 caaaatctcc ttaagctgat aagcaacttc agcaaagtct caggatacaa aatcaatgta   1140
 cagaaatcac aagcattctt atacaccaat aacagacaaa cagagagcca aatcatgagt   1200
 gaactcccat tcacaattgc ttcaaagaga ataaaatacc taggaatcca acttacaagg   1260
 gatgtgaagg acctcttcaa ggagaactac aaaccactgc tcaatgaaat aaaagaggat   1320
 acaaacaaat ggaagaacat tccatgctca tgggtaggaa gaatcaatat cgtgaaaatg   1380
 gccatactgc ccaaggtaat ttatagattc aatgccatcc ccatcaagct accaatgact   1440
 ttcttcacag aattggaaaa aactacttta aagttcatat ggaaccaaaa aagatcctgc   1500
 atcgccaagt caatcctaag ccaaaagaac aaagctggag gcatcacact acctgacttc   1560
 aaactatact acaaggctac agtaaccaaa acagcatggt actggtacca aaacggagat   1620
 atagatcaat ggaacagaac agagccctca gaaataacgc cgcacatcta caactatctg   1680
 atctttgaca aacctgagaa aaacaagcaa tggggaaagg attccctatt taataaatgg   1740
 tgctgtgaaa actggctagc catatataga aagctgaaac tggatccctt ctttacacct   1800
 tatacaaaaa tcaattcaag atggactaaa gacttaaatg ttagacctaa aaccataaaa   1860
 accctagaag aaaacctagg cattaccatt caggacatag gcatgggcaa ggacttcatg   1920
 tctaaaacac caaaagcaac ggcagcaaaa gcccaaattg acaaatggga tctaattaaa   1980
 ctaaagagct tctgcacagc aaaagaaact accatcagag tgaataggca acctacaaaa   2040
 tgggaggaaa ttttcgcaac ctactcatct gacaaagggc tgatatccag aatctacaat   2100
 gaactcaaac aaatttacaa gaaaaaaaca aacaacccca tcaaaaagtg ggcaaaggac   2160
 atgaacagac acttctcaaa acaagacatt tatgcagcca aaaaacacat gaaaaaatgc   2220
 tcatcatcac tggccatcag agaatgcaaa tcaaaaccac aatga                   2265



      <210> 2326
      <211> 5186
      <212> DNA
      <213> Homo sapiens


      <400> 2326
 atggtctcag cccaaaatct ccttaagctg ataagcaact tcagcaaagt ctcaggagac     60
 aaaatcaatg tgcaaaaatc acaagcattc ctctccagca acaacaggca aacagagagc    120
 caaatcatga gtgaactccc attcacactt gctacaaaga gaataaaata cctaggaatc    180
 caatctacaa gggaagtgaa ggacctcttc aaggagaact acaaaccact actcaatgaa    240
 ataaaagagg ataccaaaaa aatggaagaa cattccatgc tcatggatag gaagaatcaa    300
 tattgtgaaa atggccatac tgcccaagaa gggaaaactt aacaaacaga aaggacaacc    360
 acacccaaaa acccatcttg tacatcaccc atcattcaaa gacccaaaag taaataaaac    420
 ccaccaaaga tggggaaaaa aacagaacag aaaaactgga aactctaaaa tgtagagtgc    480
 ctctcctcct ccaaaggaaa gcagttcctc accagcaacg gaacaaagct ggatggagaa    540
 tgactttgac gagctgagag aggaaggctt cagacgatca aattactccg agctacagga    600
 ggaaattcaa accaaaggca aagaagttga aaactttgaa aaaaatttag aagaatgtat    660
 aactagaata accaatacag agaagtgctt aaaggagctg atggagctga aaaccaaggc    720
 tcaagaacta cgtgaagaat gcagaagcct caggagccga tgcgatcaac tggaagaaag    780
 ggtatcagtg atggaagatg aaatgaatga aatgaatgaa atgaagtgag aagggaaggt    840
 tagagaaaaa agaataaaca gaaatgagca aagcctccaa gaaatatggg actatgtgaa    900
 aagaccaaat ctacatctga ttggtgtacc tgaaagtgat ggtgagaatg gaaccaagtt    960
 ggaaaacact ctgcaggata ttatccagga gaacttcccc aatctagcaa ggcaggccaa   1020
 cattcagatt caggaaatac agagaacgcc acaaagatac tcctcgagaa gagcaactcc   1080
 aagacacata attgtcagat tcaccaaagt tgaaatgaag gaaaaaatgt taagggcagc   1140
 cagagagaaa ggtcgggtta cccacaaagg gaagcccatc agactaacag cggatctctc   1200
 ggcagaaact ctacaagcca gaagagagtg ggggccaata ttcaacattc ttaaagaaaa   1260
 gaattttcaa cccagaattt catatccagc caagctaagc ttcataagtg aaggagaaat   1320
 aaaatacttt acagacgatc aaatgctgag agattacata atggtaaagg gatcaattca   1380
 acaagagctc ctgaaggaag cgctaaacat gcacccaata caggagcacc cagattcata   1440
 aagcaagtcc ttagtgacct acaaagagac ttagactccc acacattaat aatgggagac   1500
 tttaacaccc cactgtcaac attagacaga tcaacgagac agaaagtcaa caaggatacc   1560
 caggaattga actcagctct gcaccaagca gacctaatag acatctacag aactctccac   1620
 cccaaatcaa cagaatatac atttttttca gcaccacacc acacctattc caaaattgac   1680
 cacatagttg gaagtaaagc actcctcagc aaatgtaaaa gaacagaaat tataacaaac   1740
 tgtctctcag accacagtgc aatcaaacta gaactcagga ttaagaaact cactcaaaac   1800
 cgctcaacta catggaaact gaacaacctg ctcctgaatg actactgggt acataacgaa   1860
 atgaaggaaa aaataaagat gttctttgaa accaacgaga acaaagacac aacataccag   1920
 aatctctggg acacattcaa agcagtgtgt agagggaaat ttatagcact aaatgcccac   1980
 aagagaaagc aggaaagatc caaaattgac accctaacat cacaattaaa agaactagaa   2040
 aagcaagagc aaacacattc aaaagctagc agaaggcaag aaataactaa aatcagagca   2100
 gaactgaagg aaatagagac acaaaaaacc cttcaaccct tcaaaaaatt aatgaatcca   2160
 ggagctggtt ttttgaaagg atcaacaaaa ttgatagacc gctagcaaga ctaataaaga   2220
 aaaaaagaga gaagaatcaa atagacacaa taaaaaatga taaaggggat atcaccactg   2280
 atcccacaga aatacaaact accatcagag aatactacaa acacctctac gcaaataaac   2340
 tagaaaatct agaagaaatg gataaattcc tcgacacata caccctccca agactaaacc   2400
 aggaagaagt tgaatccctg aatagaccaa taacaggagc tgaaattgtg gcaataatta   2460
 atagcttacc aaccaaaaaa agtccaggac cagatggatt cacagccgaa ttctaccaga   2520
 ggtacaagga ggagctggta ccattccttc tgaaactatt ccaatcaata gaaaaagagg   2580
 gaatcctccc taactcattt tatgaggcca gcatcatcct gataccaaag cctggcagag   2640
 acacaacaaa aaaagagaat tttagaccaa tatccctgat gaacatcaat gcaaaaatcc   2700
 tcaataaaat actggcaaac caaatccagc agcacatcaa aaagcttatc caccatgatc   2760
 aagtgggctt catccctggg atgcaaaaat cctcaacata tgcaaatcaa taaacataat   2820
 ccagcatata aacagaacca aagacaaaaa ccacatgatt atctcaatag atgcagaaaa   2880
 ggcctttgac aatatatgca aatcaataca tgcaataaat taggtattga tgggacatat   2940
 ctcaaaataa taagagctat ttatgacaaa cccacagcca atagcatact gaatgtgcaa   3000
 aaactggaag cattcccttt gaaaactggc acaagacagg gatgccctct ctcacctcac   3060
 cactcctatt caacatagta ttctgcccca tagtgttctg gccagggcaa tcaggcaaga   3120
 gaaggaaata aagggtattc aattaggaaa agaggaagtc aaattgtccc tgtttgcaga   3180
 cgacatgatt gtatatctag aaaaccccat tgtctcagcc caaaatctcc ttaagctgat   3240
 aagcaacttc agcaaagtct caggatacaa aatcaatgta caaaaatcac aagcattctt   3300
 atacaccaat aacagacaaa cagagagcca aatcatgaat catgagtgaa ctcccattca   3360
 caattgcttc aaagagaata aaatacctag gaatccaact tacaagggat gtgaaggacc   3420
 tcttcaagga gaactacaaa ccactgctca gtgaaataaa agaggataca aacaaatgga   3480
 agaacattcc atgctcatgg gtaggaagaa tcaatattgt gaaaatggcc atactgccca   3540
 aggtaattta tagattcaat gccatcccca tcaagctacc aatgactttc ttcacagaat   3600
 tggaaaaaac tactttaaag ttcatatgga accaaaaaag agcccacatt gccaagtcaa   3660
 tcctaagcca aaagaacaaa gctggaggca tcacgctacc tgacttcaaa ctatactaca   3720
 aggctacagt aaccaaaaca gcatggcact ggtaccaaaa cagcatggta ctggtaccaa   3780
 aacagagata cagaccaatg gaacagaaca gagccctcag aaataatgcc gcatatctac   3840
 actattctga tcctttggac aaacctttgc ttgagaaaaa caagcaatgg gggaaaggat   3900
 tccctaattt ataaaatggc tgctggggaa aactggctag cccatatgta ggagaaagct   3960
 gaacctggca tcccttccct taccccttat acaaaaatca attcaagatg gattaaagac   4020
 ttaaatgtta gacctaaaac cataaaaacc ctagaagaaa acctaggcaa taccattcag   4080
 gacataggca tgggcaagga cttcatgtct aaaacaccaa aagcaatggc aacaaaagcc   4140
 aaaattgaca aatgggatct aattaaacta aagagcttct gcacagcaaa agaaactacc   4200
 atcagagtga acaggcaacc tacagaatgg gagaaaattt tcgcaaccta ctcatctgac   4260
 aaagggctaa tatccagaat ctacaatgaa ctcaaacaaa tttacaagaa aaaaacaaac   4320
 aaccccatca aaaagtgggt gaaggatatg aacagacact tctcaaaaga agacatttat   4380
 gcagccaaaa gacacatgaa aaaatgctca tcatcactgg ccatcagaga aatgcaaatc   4440
 aaaaccacaa tgagatacca tctcacacca gttagaatgg caatcattaa aaagtcagga   4500
 aacaacaggt gctggagagg atgtggagaa ataggaacac ttttacactg ttggtgggac   4560
 tgtaaactag ttcaaccatt gtggaagtca gtgtggcgat tcctcaggga tctagaacta   4620
 gaaataccat ttgacccagc catcccatta ctgggtatat acccaaagga ttataaatca   4680
 tgctgctata aagacacatg cacacgtatg tttattgcgg cactattcac aatagcaaag   4740
 acttggaacc aacccaaatg tccaacaatg atagactgga ttaagaaaat gtggcacata   4800
 tacaccatgg aatactatgc agccataaaa aatgatgagt tcatgtcctt tgtagggaca   4860
 tggatgaaat tggaaaccat cattctcagt aaactatcgc aagaacaaaa aaccaaacac   4920
 cgcatattct cactcatagg tgggaattga acaatgagat cacatggaca caggaagggg   4980
 aatatcacac tctgggggac tgttgtgggg tggggggagg gggggaggga tagcattagg   5040
 agatatacct aatgctaaat gacgagttaa tgggtgcagc acaccagcat ggcacatgta   5100
 tacatatgta actaacctgc gcattgtgca catgtaccct aaaacttaaa agtataatta   5160
 aaaaaaaata aaataaaaat aaaaaa                                        5186



      <210> 2327
      <211> 1966
      <212> DNA
      <213> Homo sapiens


      <400> 2327
 gcagatttac cattttccag tgagtttttc actctatggt ataactggct tccttccaag     60
 caaatgcctt gcaaaaagaa tgaagaaaat gaggactctg tatttcaacc aaaccagccg    120
 ttagtagatt ctatagactt ggatgcagtg tcagccttac ttgcaagaac atcagctgag    180
 ttgttagctg tggaacaaga attagcacaa gaagaagaag aagaatcagg acaagaagag    240
 ccaaggggcc cagatggaga ctggctaaca atgctaagag aggcctctga tgaaattgtg    300
 gctgaaaaag aggctgaagt taaattgcca gaggacagta gctgtacaga agatttaagt    360
 tcatgcacta gtgtgcctga gatgaatgaa gacgggaaca ggaaagaaag caactgtgcc    420
 aaagacctca gaagtcagcc acctactaga ataccaacac tggttgacaa agagacaaac    480
 actgatgaag ccgctaatga caatatggca gttcgcccca aagagcgcag cagcctgagc    540
 tctagacagc atccgtttgt gaggagcagt gtgatagtgc gctcacagac cttttctcca    600
 ggagagcgga accagtacat ctgcaggtta aatcggagtg acagtgacag ttcaaccctg    660
 gctaaaaaat cactgtttgt gagaaactcc accgaacgcc gcagtttgag ggtcaaaagg    720
 acggtttgcc agtcagtcct tagaagaaca acacaggaat gcccagtgcg gacatctcta    780
 gacttagaac tggaccttca ggcatctctg acccggcaga gccgcctcaa tgatgagctg    840
 caggcgctga gggacttgcg gcagaagctg gaggaactga aagctcaggg agagactgac    900
 cttccaccag gcgtgctgga ggatgagagg ttccagaggc ttctgaagca agctgagaag    960
 caggctgaac agtccaaaga agagcagaag caaggtctga atgcagagaa gttgatgagg   1020
 caagtctcca aggacgtgtg tcggctccgg gagcagagcc agaaggtgcc tcggcaggtg   1080
 cagtccttca gggagaagat tgcctacttc accagagcaa agataagcat cccatccctg   1140
 ccagctgatg atgtgtgatt acatgactta agaaattatt ttttcatctg ttcactttct   1200
 tagggagggt aaaagactga agatttgtgt ttttgttttg gggtttggtt ttttttggta   1260
 acgtaactgt caactcttga agaactttta tttcacatca gattttcaac acattaattt   1320
 gtaaagtacc ttgagtgtaa tttttatatg cttaaaaaag aaaaaatcat ataagaaaga   1380
 tgggataacc tggtacacaa atgttgccca gtatgtgcgc attgccagtg gacttcattt   1440
 tgtaaaaatg gaatagaggc agtaccccac ttgtgtactg ttgagccggc tgttgagaaa   1500
 caacttggtt cagccggtgg ttttgcttct cctttgtgtt cctgtgagta ggctgtgccg   1560
 atggcagcag cgccacgtgg tatctgtgcg ctggcgagga gaggagcgct ttccatttgg   1620
 aggcagtgtg agcacacgct ggagtgcagc gttccaaagt ccgcccgaaa tggatgctgc   1680
 gtccacggcc atcacctgtg cgggaacacc tggtttcctt aagacaattt cctttttgtc   1740
 cttttatatt tttctaaaga aaactaagat ataaactacc aagtgctctt aagaataaaa   1800
 ataagaataa gaatacaaag gagcactact cttggctaca cgaaagatct tgggattcat   1860
 gacactgagg gcagggagaa gaaagaacac cagccacgca gagatacaaa taagctcatc   1920
 aaatgagcag ctggtttgtc tcactcagcc tgaatttgca ttaagt                  1966



      <210> 2328
      <211> 2526
      <212> DNA
      <213> Homo sapiens


      <400> 2328
 ccctgatgaa cattaggcca gtgcggtgga attcctctct gcgcatctga cggaaggacc     60
 ttcctttccc gttgtgaatt tcttcgtgcc ttgtgcaaag atccccagct agagattgca    120
 tatcgaggaa actgcaaaga cgtgtccagg tgtgtggccg aaaggaagta tacccaggag    180
 caagcccgga aggagtttca gcaagtgttc attcctgagt gcaatgacga cggcacctac    240
 agtcaggtcc agtgtcacag ctacacggga tactgctggt gcgtcacgcc caacgggagg    300
 cccatcagcg gcactgccgt ggcccacaag acgccccggt gcccgggttc cgtaaatgaa    360
 aagttacccc aacgcgaagg cacaggaaaa acagatgatg ccgcagctcc agcgttggag    420
 actcagcctc aaggagatga agaagatatt gcatcacgtt accctaccct ttggactgaa    480
 caggttaaaa gtcggcagaa caaaaccaat aagaattcag tgtcatcctg tgaccaagag    540
 caccagtctg ccctggagga agccaagcag cccaagaacg acaatgtggt gatccctgag    600
 tgtgcgcacg gcggcctcta caagccagtg cagtgccacc cctccacggg gtactgctgg    660
 tgcgtcctgg tggacacggg gcgccccatt cccggcacat ccacaaggta cgagcagccg    720
 aaatgtgaca acacggccag ggcccaccca gccaaagccc gggacctgta caagggccgc    780
 cagctacaag gttgtccggg tgccaaaaag catgagtttc tgaccagcgt tctggacgcg    840
 ctgtccacgg acatggtcca cgccgcctcc gacccctcct ccttcgttca gggcaggctc    900
 tcagaacccg accccagcca taccctagag gagcgggtgg tgcactggta cttcaaacta    960
 ctggataaaa actccagtgg agacatcggc aaaaaggaaa tcaaaccctt caagaggttc   1020
 cttcgcaaaa aatcaaagcc caaaaaatgt gtgaagaagt ttgttgaata ctgtgacgtg   1080
 aataatgaca aatccatctc cgtacaagaa ctgatgggct gcctgggcgt ggcgaaagag   1140
 gacggcaaag cggacaccaa gaaacgccac acccccagag gtcatgctga aagtacgtct   1200
 aatagacagc caaggaaaca aggataaatg gctcataccc cgaaggcagt tcctagacac   1260
 atgggaaatt tccctcacca aagagcaatt aagaaaacaa aaacagaaac acatagtatt   1320
 tgcactttgt actttaaatg taaattcact ttgtagaaat gagctattta aacagactgt   1380
 tttaatctgt gaaaatggag agctggcttc agaaaattaa tcacatacaa tgtatgtgtc   1440
 ctcttttgac cttggaaatc tgtatgtggt ggagaagtat ttgaatgcat ttaggcttaa   1500
 tttcttcgcc ttccacatgt taacagtaga gctctatgca ctccggctgc aatcgtatgg   1560
 ctttctctaa cccctgcagt cacttccaga tgcctgtgct tacagcattg tggaatcatg   1620
 ttggaagctc cacatgtcca tggaagtttg tgatgtacgg ccgaccctac aggcagttaa   1680
 catgcatggg ctggtttgtt tcttgggatt ttctgttagt ttgtcttgtt ttgctttcca   1740
 gagatcttgc tcatacaatg aatcacgcaa ccactaaagc tatccagtta agtgcaggta   1800
 gttcccctgg aggaaataat attttcaaac tgtcgttggt gtgatacttt ggctcaaagg   1860
 atctttgctt ttccatttta agcttctgtt ttgagttttg ccctggggct tgaatgagtc   1920
 ccagagagtc gttcggatgg tgggaggctg cctaggaggc agtaaatcca gtcacagtgc   1980
 ctgggagggg cccatccttc caaaatgtaa atccagtcgc ggtgtgaccg agctggctaa   2040
 caggcttgtc tgcctggttt tcctcctaca cgtggacatt attctcctga tcctcctacc   2100
 tggtccaccc cagggctacc ggaaggtaaa atcttcacct gaaccaatta tgagcagtct   2160
 ccttactgaa ggtacagccg gatacgtggt gcccccgggg ctggtgttgg cagccggggg   2220
 gaggtgcctg agggtcccca cggttccttt ctgcttttct gaatgcatca agggtacgag   2280
 aacttgccaa tgggaaattc atccgagtgg cactggcaga gaaggatagg agtggaatgc   2340
 ccacacagtg accaacagaa ctggtctgcg tgcataacca gctgccaccc tcaggcctgg   2400
 gccccagagc tcagggcacc cagtgtctta aggaaccatt tggaggacag tctgagagca   2460
 ggaacttcaa gctgtgattc tatctcggct cagacttttg gttggaaaaa gatcttcatg   2520
 gcccct                                                              2526



      <210> 2329
      <211> 2811
      <212> DNA
      <213> Homo sapiens


      <400> 2329
 cagagacgga cacaggatga gctctaagta cccgcggtct gtccggcgct gcctgcccct     60
 ctgggcccta acactggaag cagctctcat tctcctcttc tattttttta cccactatga    120
 cgcttcctta gaggatcaaa aggggctcgt ggcatcctat caagttggcc aagatctgac    180
 cgtgatggcg gccattggct tgggcttcct cacctcgagt ttccggagac acagctggag    240
 cagtgtggcc ttcaacctct tcatgctggc gcttggtgtg cagtgggcaa tcctgctgga    300
 cggcttcctg agccagttcc cttctgggaa ggtggtcatc acactgttca gtattcggct    360
 ggccaccatg agtgctttgt cggtgctgat ctcagtggat gctgtcttgg ggaaggtcaa    420
 cttggcgcag ttggtggtga tggtgctggt ggaggtgaca gctttaggca acctgaggat    480
 ggtcatcagt aatatcttca acacagacta ccacatgaac atgatgcaca tctacgtgtt    540
 cgcagcctat tttgggctgt ctgtggcctg gtgcctgcca aagcctctac ccgagggaac    600
 ggaggataaa gatcagacag caacgatacc cagtttgtct gccatgctgg gcgccctctt    660
 cttgtggatc ttctggccaa gtttcaactc tgctctgctg agaagtccaa tcgaaaggaa    720
 gaatgccgtg ttcaacacct actatgctgt agcagtcagc gtggtgacag ccatctcagg    780
 gtcatccttg gctcaccccc aagggaagat cagcaagact tatgtgcaca gtgcggtgtt    840
 ggcaggaggc gtggctgtgg gtacctcgtg tcacctgatc ccttctccgt ggcttgccat    900
 ggtgctgggt cttgtggctg ggctgatctc cgtcggggga gccaagtacc tgccggggtg    960
 ttgtaaccga gtgctgggga ttccccacag ctccatcatg ggctacaact tcagcttgct   1020
 gggtctgctt ggagagatca tctacattgt gctgctggtg cttgataccg tcggagccgg   1080
 caatggcatg attggcttcc aggtcctcct cagcattggg gaactcagct tggccatcgt   1140
 gatagctctc acgtctggtc tcctgacagg tttgctccta aatcttaaaa tatggaaagc   1200
 acctcatgag gctaaatatt ttgatgacca agttttctgg aagtttcctc atttggctgt   1260
 tggattttaa gcaaaagcat ccaagaaaaa caaggcctgt tcaaaaacaa gacaacttcc   1320
 tctcactgtt gcctgcattt gtacgtgaga aacgctcatg acagcaaagt ctccaatgtt   1380
 cgcgcaggca ctggagtcag agaaaatgga gttgaatcct ttctctgcca ctctttgagg   1440
 agaatctcac catttattat gcactgtaga atacaacaat aaaatacagc catgtaccac   1500
 ataacaacat ctggtaaaca acagactgca tatatgatgg tggtcatcca gtaagctaag   1560
 gttaatttat tattattcct tgtttttttt tttttttttt tttttttttt ttgggatgta   1620
 gtcttactct gtcacccagg ctagagtgca gtggcaccat cttggctcac tgcaacctct   1680
 acctcctggg ttcaagcaat tctcctgcct cagcctcccg agtagctggg attacaggca   1740
 cccaccacat ctggctaatt ttttgtattt ttagtaaaga tggggtttca ccatgttggc   1800
 caggctgatc tcaaactcct gacctcaagt gatctgcccg cctcggcctc ccaaagtgct   1860
 ggaaccacag gcctgagcca ctgtgcccag ccttgtttgc ttttttaaca gataacagtg   1920
 tgctcataga aactgctttg acatgactgc aatcatgtgc ttcatagaaa cttaattaga   1980
 ttataccact agagtcttca gatttttata cttttttttt tgaaacggag tctcactctg   2040
 tcaccaggct ggagtgcagt gccgcaatct cggctcactg caacctccgc ctcccaggtt   2100
 caagcaattc tcctgcctca gcctcccgag tagctgggat tacaagtgca cactaccacg   2160
 cccagctaat ttttgcattt ttactagaca gggtttcacc atgttggcta ggatagtttc   2220
 accaggatct cttggcctca tgatcagcct gcctcggcct cccaaagtgc tgggattaca   2280
 ggtgtgagcc accgtgccca gcctatactt ccctttttga ataccatttg ggcgttttga   2340
 agaattaaca gctttgtgaa cgtggcagtg cttgtgattc aggcttccac tgagaccaag   2400
 gggagaacct ggttgcagga caaacagacg gacagcgtgt ggcagtgttt aaatgctctt   2460
 ctgaaggctg atacgacagc tctctgtgca ctgattgcat atgcatccca agattatatt   2520
 attgttttct actgctatgt gtcacacttt gccaaacagg atgtggaaaa tgaataagcg   2580
 gttttcctta aggcaccttc cttaacaaga caattggtca aaatgaactc cattgcttaa   2640
 gaaacacata aacaccattt agtcactgaa catagctata tgtatggttg ttactatggg   2700
 aaatcttgtt ttgccaattt tctttgaaaa ttctggcaga ccaaggttct ttttgtttac   2760
 ataatacttg aaaaataaaa atgaacaagc taacaaacta ccaagttttc a            2811



      <210> 2330
      <211> 1799
      <212> DNA
      <213> Homo sapiens


      <400> 2330
 ttttttatct gtacagaaat atttacttta gatgacaaaa gaactcaaga tcacagtaca     60
 cagcagttat ttatttaaat acttgaaaag gctgatgatg gaaaaaatag gtttatcatg    120
 agagtttata ttcattagat ttattttatc atttaaaaaa ttactgcctc taggttatcc    180
 tagcctgata tagaacactt ggtgacacat gcagttactg taatatacta taacagacac    240
 agccattata gaatgattta cacttgggat gaaattcaac agtagtaagg gtgactcttt    300
 atttaaacta aaaacattgg taatatacaa attttttttt tatttcattg aaagggctat    360
 aaaattcaac atactgacaa ggaagcaaca taatcacata gataacgcct ctgctaattg    420
 cttttaccta acttcaccct taaaggtgag ctgcacactc agctacacaa gtttctagac    480
 tgtgcgatgg gcttcaaggc tgggcctacc acaactgact gaaaaaatgt catgttggta    540
 agctgacact gacttgtatg tttttaaaaa tggagagaca atggcaaatt gtaccttatg    600
 tccttataga acccaaagga tcattctgag taaatgtgaa ataaataaag tgatccatga    660
 gtaaatacaa tctctgggct aacttaaacc tagaagagtg agccaagtga gcactaacaa    720
 taccacttag aaatgtctag aaacatcatt tctagaactc agcttgggag accatatctt    780
 gcctgaatat gtacatatat ttacaaaata ttcccttttg gcctctggaa tttagccatt    840
 ttagtttggc tgttagctgt tttctttcca tatgctagcc aatactgcag ttataactat    900
 cattaaaata ctcttatgca tgaattacaa atattaataa agtaactctg catgtataaa    960
 tatctcaata attctagcag aacttaaagc attcagaatg tacataaaag tatttgtttt   1020
 tggtagggac agtatttctt tttatatcat cgctgtttca ataatgcttt gtacatagca   1080
 aagcccaaaa ctgcaaaaac agtagcacca aaacttgctc gaagccaaaa cgtggagctc   1140
 ttgaggtcag cttgtgtcac gtgcggatac atggccattg ttgtcaattt aacaaagata   1200
 tccttactgg gggcatcagc agtattgcaa gtgaaggctt gtggtggagg cattttgtgt   1260
 ttcctgcaga aatcagtagg tgaaatactg tattcttgtt taacttcatg caggtctgac   1320
 tttgcagcta cgattaagca aggtattctg ctgtccataa agtgttgctt aaaaatcctg   1380
 gcacagtatt caaaggattt gggattgctg acatcatata ccaggcatac aacatcacaa   1440
 atgatttcag cttcagttag aaattccgat tctgagatat catgcaacaa caagtatttc   1500
 tcttgtccat atacataaac agtgttaatc gcatagtagg atttatgatc ttcacgaatt   1560
 ttcttctgcc tcattaagtt tcttccaaga agagcctgaa gaactccact tttcccacag   1620
 tttttcactc caattacatt acatctgaac acatttcttt gagtttgttt tttctgcagg   1680
 tctatctttt tatctcttgt cactgtaaca gctgaagctt gagactcttg ctcagtcaat   1740
 attgaatagc ctagatagcc caaatattcc aggcaccgct gtacatctaa ataagtcgt    1799



      <210> 2331
      <211> 3200
      <212> DNA
      <213> Homo sapiens


      <400> 2331
 tttcgtgtgg cggtggctga ggcggttggg cctagggtgc agcgggcgcg tctgcggctg     60
 gtgttggcgc atctctagat cctttcccgg agttcagtta tgggtgtgag aggtttgcaa    120
 ggatttgtgg gaagtacctg cccacatata tgtacagtag taaatttcaa agaactggca    180
 gagcaccacc gaagcaagta tcctggatgt acccctacca ttgtggttga tgccatgtgt    240
 tgtctcagat attggtatac tccagaatct tggatctgcg gtggccagtg gcgagaatac    300
 ttttctgctt tgcgagattt tgttaaaact tttacggcag ctgggatcaa gttgatattc    360
 ttctttgatg gcatggtgga gcaggataag agagatgaat gggtgaaacg aaggctcaag    420
 aacaacaggg agatatccag gatttttcat tacatcaagt cacacaagga gcagccaggc    480
 agaaatatgt tcttcatccc ctcagggcta gctgtgttta cacgatttgc tctaaagaca    540
 ctgggccagg aaactttgtg ttccttgcag gaagcagatt atgaggtagc ttcctatggc    600
 ctccagcata actgtcttgg gattctgggg gaagacactg attacctaat ctatgacact    660
 tgtccctact tttcaattag cgagctctgc ctagagagcc tggacaccgt catgctctgc    720
 agagagaagc tctgtgagag tctgggcctc tgtgtggccg accttcctct tctggcctgc    780
 ctccttggca acgacataat cccagagggc atgtttgaaa gctttaggta caaatgctta    840
 tcgtcctaca cctctgtaaa agagaacttt gacaaaaaag gtaacatcat attagctgtg    900
 tcagaccata tatcgaaagt tctttacttg tatcaaggtg agaaaaaatt agaagagata    960
 ttacctctgg gaccaaacaa agctcttttt tataaaggaa tggcatcata tcttttacca   1020
 ggacaaaaat ctccatggtt tttccaaaaa cccaaaggtg taataacttt ggacaaacaa   1080
 gtaatatcca cgagttcaga cgccgaatcc agggaagaag ttcccatgtg ttcagatgct   1140
 gaatccaggc aagaagttcc catgtgtaca ggccctgaat ccaggcgaga agttcccgtg   1200
 tatacatatt ctgaacccag gcaagaagtt cccacgtgtt cagaccctga acccaggcaa   1260
 gaagttccca cgtgtacagg ccctgaatcc aggcgagaag ttcccatgtg ttcagaccct   1320
 gaacccaggc aagaagttcc catgtgtaca ggccctgaac ccaggcaaga agttcccatg   1380
 tgtacaggcc ctgaagccag gcaagaagtt cccatgtgta cagactctga acccaggcaa   1440
 gaagttccca tgtgtacaga ctctgaaccc aggcaagaag ttcccatgta tacaggctct   1500
 gaacccaggc aagaagttcc catgtataca ggccctgaat ccaggcaaga agttcccatg   1560
 tatacaggcc ctgaatccag gcaagaagtt ttaatacgga cagaccctga atctaggcaa   1620
 gaaattatgt gtacaggcca tgaatccaaa caggaagttc ccatatgtac agatcctata   1680
 tccaagcaag aagactccat gtgtacacac gctgaaatca atcaaaaatt acctgtagca   1740
 acagattttg aatttaagct agaagctctc atgtgtacaa accctgaaat taaacaagaa   1800
 gaccccacaa atgtggggcc tgaagtaaag caacaagtaa ccatggtttc agacactgaa   1860
 atcttaaagg ttgctagaac acatcacgtc caagcagaaa gctacctggt gtacaacatc   1920
 atgagcagtg gagagattga atgcagcaac accctagaag atgagcttga ccaggcctta   1980
 cccagccagg ccttcattta ccgtcccatt cgacagcggg tctactcact cttactggag   2040
 gactgtcaag atgtcaccag cacctgccta gctgtcaagg agtggtttgt gtatcctggg   2100
 aacccactga ggcacccgga cctcgtcagg ccgctgcaga tgaccattcc agggggaacg   2160
 cctagtttga aaatattatg gctgaaccaa gagccagaaa tacaggttcg gcgcttggac   2220
 acactcctag cctgtttcaa tctttcctcc tcaagagaag agctgcaggc tgtcgaaagc   2280
 ccatttcaag ctttgtgctg cctcttgatc tacctctttg tccaggtgga cacgctttgc   2340
 ctggaggatt tgcatgcgtt tattgcgcag gccttgtgcc tccaaggaaa atccacctcg   2400
 cagcttgtaa atctacagcc tgattacatc aaccccagag ccgtgcagct gggctccctt   2460
 ctcgtccgcg gcctcaccac tctggtttta gtcaacagcg catgtggctt cccctggaag   2520
 acgagtgatt tcatgccctg gaatgtattt gacgggaagc tttttcatca gaagtacttg   2580
 caatctgaaa agggttatgc tgtggaggtt cttttagaac aaaatagatc tcggctcacc   2640
 aaattccaca acctgaaggc agtcgtctgc aaggcctgca tgaaggagaa cagacgcatc   2700
 actggccgag cccactgggg ctcacaccac gcagggaggt ggggaagaca gggctccagc   2760
 taccacagga cgggctctgg gtatagccgt tccagtcagg gacagccgtg gagagaccag   2820
 ggaccaggaa gcagacagta tgagcatgac cagtggagaa ggtactagtc aacctccaga   2880
 aagagtatgg agagaaaaag aggcacacct ggacgcagag ccctgccagc gccctcctct   2940
 gctgttgcag ctgcaaggag accatgcctg tgggagccag gcctcgcttg catgaagaag   3000
 gaacgatgcc tttttcaatg gtgtctccct cccattgtgc agaagagctt ttgttggctt   3060
 ctctcccgag cttgtgcctg attctgtggc ccaaaacaat cattgttaac atcttcatgt   3120
 gtttcattct gatctttcat tcatatatat gatgcctagc taatttcatt ttaaaataaa   3180
 tgggaatctg ttgtaaaaaa                                               3200



      <210> 2332
      <211> 513
      <212> DNA
      <213> Homo sapiens


      <400> 2332
 atggcctggg ctctgctcct cctcaccctc ctcactcagg gcacagggtc ctgggctcag     60
 tctgccctga ctcagcctcc ctccgtgtcc gggtctcctg gacagtcagt caccatctcc    120
 tgcactggaa ccagcagtga cgttggtagt tataaccgtg tctcctggta ccagcagccc    180
 ccaggcacag cccccaaact catgatttat gagaatttta gcaactacat tctaatggtt    240
 atcgccacaa ctttgatctt aaataacagt gcagcgaaca tccctacgca gactcctttg    300
 agttcctgtg tgaatatgac cacaggattc atttctaaaa gtgaaattgc agatgttgct    360
 gatgctgact tgttcatctc ttccaacctc tgcaaacaaa gtgggaaatt ggatttttct    420
 gaacacccag atgacaacgg gagaggaggc tttgtggctt cccgtaagct gactccagag    480
 ccagcagtgt ctgtggacag tcagcaaggg taa                                 513



      <210> 2333
      <211> 2174
      <212> DNA
      <213> Homo sapiens


      <400> 2333
 tttttttaaa ataaatcagt gtgttttttt attttgagcc aatgttttac ataagaccaa     60
 caaactaagt gtgggcaaac tgttcaatca cttttgagaa attacatggt tcctatttag    120
 gtttgaaaaa gtagtttgtt gccataacat cagaccttaa ggtgttttaa agtgtatcct    180
 aagggtactg acagaagaaa aatacagtgt tatggaagta tacacaactc atgaccacac    240
 agtatagatc cattcatggt gaataatgtt catctgttct ccaaaggtag tgaaaaatat    300
 taagtcatca aataaatgct cagaattacc aaggaacagt taaaaaggac caggatccaa    360
 acaggttatt tatatattta tctataaaca agtgacaaca ctaaaaaaca cattgaaaac    420
 cagtgtttta aactctgaat gtgggattta aaaatattcc attaacttga gattgcaata    480
 atttttttaa accaaatagc atttgactgg caagtctcat ataatttaca gctgtaatat    540
 tcctaaaagg aatatctaca tactatagcc tatcaaatat aatctgcatt ttgcaaatca    600
 atacaaaaat ctatccatca tttatacatt ttatatttat atacttttta aaaattagat    660
 tttattgcta ggtgaatttg gaattcaaat taaatttgga aacttaataa tgctcttctc    720
 ataaccttct ccccattctt tttttaattt ttaaacactg gaagcaaatg attatcaaaa    780
 tgagactgca acttaaggca ttttaaaaga aaaaataatt aggtgccata tagcatttta    840
 tttcaaaagt atattttgtc ccacttttct cactagcaag agtaaaacac aaaccttttt    900
 tcataaatat gactacagta atcataacac aaaaaagggt tgataggcat tgcttagata    960
 tttaaaacaa gggtaatact ttcccactca cctaaaagaa aaaacctttt tgattaccag   1020
 tttataaaca tcggatttgc tatgttaaaa agtccagcag aattttaatt cagcaacact   1080
 ggagaatgaa tatatatata caggcataca tgtgtatgta tatattcatt ttatatatag   1140
 tcaatgtatt tattaggcat tcccccacaa aagtaattta tatttaattg ccatttttaa   1200
 taaacactta tgttcacaga tcatccatct gtcttatatg aagttaggca atatcaaatg   1260
 tcctgttatg gtctccgtct tcttcggaat catcctctga agtttcgaga tcttccatat   1320
 gtgcctgaag agttcttgca aggttaataa atcggacacg tgtgcttggt tcatttgtat   1380
 ttcccatcat atcagaaaag ctttgttcgc acaagtgcaa taacaccact aggtagagac   1440
 cagagctgat aaactcatac tcagcttgtt catttgcatg agctctatgt agttcatgaa   1500
 tatcaaaatc ctccaggtta agctccaact tctctttaca tagttcacag gtggttacag   1560
 cttctaatga agaaccagag ttaattttgg cctgtaacca ctttttcata cagtcttggt   1620
 ggacatactg caaacttcct gtgcacttgc atggctctat cagcaaatta gatgatgatg   1680
 cagctgccat ttgacaaatt ctacataagt caccttcttc ttcttctgag tcctctaaaa   1740
 ggaggctctc ttttattttc tgcaatcttt ctggatctct tgaaggcgca cttttagttt   1800
 tatcactttt accatcagct gaattccaac ctgaaggaat aatatctact gtgatcatga   1860
 cattgtcggt caaattactc ccaagtgctg gggggactgc aaaccggaat aaggaaccag   1920
 gaagaatccc tgatattcct gtatttcttc caccttgagc cgaatctgat gtagagccac   1980
 ctgttgtggc actgcttgat gctgcagatg cttgtggtct gttggcagca gctccaagag   2040
 gatcattctg tgcttcaagg tgaaccactt catttgattc tcttctaaaa atatgagatc   2100
 tagatgatgt atcagaggta ggtatccttg aagattcatc tcttccctct cgcctccttc   2160
 tagagaacaa aggt                                                     2174



      <210> 2334
      <211> 2313
      <212> DNA
      <213> Homo sapiens


      <400> 2334
 cctcctgcag ttgctcccac tgtctcccaa atctggcgaa cttttaggca atggtaatgg     60
 caagtagcca tggaattaat tctgtgtggt aagaggcaca cagacagatg atgagcagct    120
 cttctcctta aagaagtctg tgtctaattc ctacgcgtgg ccgttgtcag agtatagctc    180
 tttcccgtta cctttactag ccagaaacag cttgcttgct ttctgaagaa agagaaatga    240
 cgcaccacag ggtacatcag atgaatcaga aattacattg tttggacttc aaaacagtgt    300
 ttactgactc tgggcttaaa cttctagtcc actcctagaa cagaaaccct caaagttcaa    360
 gagtgttttt ttttgtacaa ttgtttatac aaattcaaca aaggtaaaat cgcatcaggg    420
 aaggtctagg aaacaccacc ttacaacaat ggcacttata aatgcagaac tttacaacta    480
 ggaaatagcc atgttacaaa cctaaatgag aactcaactc acacttcaga ggagagaagc    540
 aaaagcaaaa gaaaggctat gtgggagcat ttattctacg tcttgactca ctgtataaat    600
 tagatctatg taagtacaag agctcatgct ggagcagaac ctcctgagtg caaaggctga    660
 agtcgaaatt ttaaaatttg agaaaagtga attctctaca gaggaaactt ggcagagtat    720
 cttactttga ctataattta catttatcca caacatgctc atgtaactct tgaggtacaa    780
 agcagactct caacttccag ttaaacatgc ttttaagtgg aaggtcttag cctactttgt    840
 tagatctggg cacatttgta gatgggttgt gtcgatgaag tacacgttaa attctctcct    900
 accttaagga aatcaggaaa attggcaatc tcaaaacaat aaaaacactg gtatgcattc    960
 aaaccttgca taaataactt ttaaacaatt tgtacaaaaa tagttctgca taatgtaaga   1020
 tgtaacaaaa ccaaccaaac aaaaaaaagt gtcaagacgg cagcagatgt ggtgtgtggt   1080
 ccactttatg tcaacaccca aaacctcggt gttgcaagga atgaagtgtc caaaacacca   1140
 ctaccactaa cagaaactcc taagctcatg cttcagtatg agaatttctc cgaagtccac   1200
 cctcctctcc gacaggaatg tcttcttgta aaggccgcct tagaaatggt ccagaaagca   1260
 gtgcagttac gattcagaaa gaccaaagga aagtgtcggc tcactcatcc cccaaacggg   1320
 tggttgaaca gcttctccct tggaaagact tgcaaaatgg aattgcgttg tggtctgttg   1380
 tcccacgttc caaatggaaa ataaaagccc tcatttttgt aaagtctctc ccctcccaga   1440
 gcccgccccg tatttacata cttatccttg gactaactca gtttttgcag gagtttttct   1500
 tctaacttgc ccaaactgga cactcacaga catctcggct atgaactgct cacagccttc   1560
 cttggtgact tgcttgcagt acctcaggtc aatatgacag atgtttccac agcgtttgaa   1620
 gaaggacagg cactgatcag tgaccttatt gcagtcagac aggttgatct cggttaagga   1680
 gtctcgggtg gtggtgccaa cagcagtgag caggttgata gactggtcgg tgacgtggtt   1740
 acagtaactg aggtggagct tggagagcag gggcatgtgg cggatgatga gccgcaggga   1800
 ggcatctgtg atgtccaggc ctgccaggcg cagctccacg atgttccgga gcttgctccg   1860
 attgtccatc tgacctggcc tgttgtctgt gggcggggac aggagatccc gcatctgggc   1920
 atcctttagt ccctccaccc actggacatc cagggtccgg agcagcggac aactggagct   1980
 gcaaagggcc gagaccgcga tccatgagca gcctgacagc accaagtccc ggagcccagg   2040
 cagccggttg atgagccagc tcagctgctt cttggagata ttggtccagc tgaggtcgag   2100
 ggagacgggc tgtcgccgga tgatgccact cagcatcagg ggtgtgatag acttgcagtg   2160
 gttcaggtca atgcgggtcc acaaccgctt atcgcagcac cagcggttcc aggtcctgca   2220
 gacccgcatg cacacacaca ggtcttggtg gctgaggtag ctgaagacgg ccatccacac   2280
 ctccctgtgc atgacgtggg ctgccccatc gtc                                2313



      <210> 2335
      <211> 2142
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> misc_feature
      <222> (1)...(2142)
      <223> n = a,t,c or g


      <400> 2335
 tttttttttt ttacaggctc aaaaatcaag tttaatatca aaagaagtta cacataaagg     60
 tttttacatt tccgaaaatc tgatagttaa aatatcccgt ctggtgttga ttgtgataca    120
 cttaagtgaa cccctgaaaa cctttatttt gaaattgaag tttttgctca gaaactgggc    180
 agaacttttc acattctgac agaagataaa acttaagtct aaaaaatatt cggtaacttt    240
 tttctcaaaa acattaagta ctttagaata taaagcagaa actcttacca agcatgtgta    300
 cccatcagcc acacctcctg tctttggggg aatttggtta cttggagctc tgtgggtgct    360
 atatgaatcc tagagacagc aaacttctgc tgtacagcta acttacaagg gcctgaaccc    420
 ggctgatggc agcaagcctg ctacagtcca gaagagtgcg acttcttata tttacatatg    480
 aacgcatctg tctttccaag gctaactttg tagcattcca ctggtaccaa ggagccaaat    540
 ggtgacattc tgtctaagaa tttgtggtta ctggcttcga atgaagttga cgctgtcttg    600
 aatgcaccag ttttttcttc aggattcaag cactttttaa ttccaggttc atctgtgtga    660
 ctgtccttgg aattgaaagg gatgttgctc tctttacaat ctgtaaggcg cctgtggtga    720
 tcttcactaa gcaacaatac aatggttccg ccaacatgaa gcactctttc catttcttgt    780
 agaatgcttt tgatgtcttt tcctaactta aactttttcc caaatggaat gtcagaaata    840
 ataatatcaa cactttctga aggcaatggc aattctataa cagagatttt aagtaattca    900
 attttatcct caaggcctgc agctttcaga ttgtcccaag tacctagtaa ctgtgagtcg    960
 ctgacatcag cacctacata atacacatct ggccattctt tagcagcttc caaaagtatt   1020
 gttccaagtc cacacattgg atctaaaaca aatgcaccag ccccactgtc aggcccagtc   1080
 gtgctcgaga taggggagaa aagacatcca ccacttgata tgtctacaga ggaagcagag   1140
 tcctcagtgc acagccaggt ttcagtcaga gccatatggt accttaatgt cagccagaga   1200
 tgccattgcc cacgctattg tagatcgcag tccagctgtc ttgatgtaag ctctgctggc   1260
 tagggaaacc ctgaacacag gaatccccac cacagagtaa atgtcattta gatgtataaa   1320
 gatctctaat tgtggattcc tcaagtctgc tttccatcca aagtgtttca taatagcaat   1380
 tccaattact tttcctacct cctgtgcagt gaaggccttt ccaatagttc cactgcagcg   1440
 acaagatact ctgaaagtca agtcattctg attatgagta tcaattgctt tctctatgtc   1500
 attctgaaat tcttcttctt gaaacttttc gcttttagtg gtaaaatctc tttgctccag   1560
 agtttcttct tttatttgtt tttccagctg gcagtcccta ttctcttcta tcttttgcat   1620
 ttgttctatt tttaatttct ttgcaatgat ttcattttct cccacttttc tttttagttg   1680
 gttatcatct ctctgagaaa gtttttcctt ttttgcatca agttcaagaa gatttttcca   1740
 aattgaaatg gcattcaacc aacttcctgg atcttcattt ataagtcttt gcatttcatt   1800
 aaatattttt cctttactta cagaagaaat aataagtgga aactgctttt taatcagcaa   1860
 aaataatctt tctgcagatt ttaatttctt caacatattc aaatcagaac aggtggtgaa   1920
 aaaaaccttt cctgaaatat attcaacctg cgtggccgcc agccgcgccc gcacctctcg   1980
 cattacgaac ggctccaggc cgcgacccgc agtgcagaag aatcgggcgc cagcctcagg   2040
 cccggaccct ggctctccac acgaaatcgt ggncccgggn nttnctnnnn ngtngntcnt   2100
 ncagtaccan ctacggatca ggatgngccg gcccgctctc cc                      2142



      <210> 2336
      <211> 7439
      <212> DNA
      <213> Homo sapiens


      <400> 2336
 tttcgtgtta atcatttcag agaagaacac tgaactttga aaaaaatgtt ggaagccatt     60
 gacaaaaatc gggccctgca tgcagcagag cgcttgcaaa ccaagctgcg agaacgtggg    120
 gatgtagcaa atgaagacaa actgagcctt ctgaagtcag tcctgcagag ccctctcttc    180
 agtcagattc tgagccttca gacttctgta cagcagctga aagaccaggt aaatattgca    240
 acttcagcaa cttcaaatat tgaatatgcc cacgttcctc atctcagccc agctgtgatt    300
 cctactctgc aaaatgaatc gtttttatta tccccaaaca atgggaatct ggaagcactt    360
 acaggacctg gtattccaca cattaatggg aaacctgctt gtgatgaatt tgatcagctt    420
 atcaaaaata tggcccaggg tcgccatgta gaagtttttg agctcctcaa acctccatct    480
 ggaggccttg ggtttagtgt tgtgggacta agaagtgaaa acagaggaga gctgggaata    540
 tttgttcaag agatacaaga gggcagtgtg gcccatagag atggaagatt gaaagaaact    600
 gatcaaattc ttgctatcaa tggacaggct cttgatcaga caattacaca tcagcaggct    660
 atcagcatcc tgcagaaagc caaagatact gtccagctag ttattgccag aggctcattg    720
 cctcagcttg tcagccccat agtttcccgt tctccatctg cagccagcac aatttcagct    780
 cactctaatc cggttcactg gcaacacatg gaaacgattg aattggtgaa tgatggatct    840
 ggtttgggat ttggcatcat aggaggaaaa gcaactggtg tgatagtaaa aaccattctg    900
 cctggaggag tagctgatca gcatgggcgt ttatgcagtg gagaccacat tctaaagatt    960
 ggtgacacag atctagcagg aatgagcagt gagcaagtag cacaagtcct taggcaatgt   1020
 ggaaatagag ttaagttgat gattgcaaga ggtgccatag aagaacgtac agcacccact   1080
 gctttgggca tcaccctctc ctcatcccca acttcaacac cagagttgcg ggttgatgct   1140
 tctactcaga aaggtgaaga aagtgagaca tttgatgtag aactcactaa aaatgtccaa   1200
 ggattaggaa ttaccattgc tggctacatt ggagataaaa aattggaacc ttcaggaatc   1260
 tttgtaaaga gcattacaaa aagcagtgcc gttgagcatg atggaagaat ccaaattgga   1320
 gaccaaatta tagcagtaga tggcacaaac cttcagggtt ttactaatca gcaagcagta   1380
 gaggtattgc gacatacagg acaaactgtg ctcctgacac taatgaggag aggaatgaag   1440
 caggaagccg agctcatgtc aagggaagac gtcacaaaag atgcagattt gtctcctgtt   1500
 aatgccagca taatcaaaga aaattatgaa aaagatgaag attttttatc ttcgacgaga   1560
 aacaccaaca tattaccaac tgaagaagaa gggtatccat tactgtcagc tgagatagaa   1620
 gaaatagaag atgcacaaaa acaagaagct gctctgctga caaaatggca aaggattatg   1680
 ggaattaact atgaaatagt ggtggcccat gtgagcaagt ttagtgagaa cagtggattg   1740
 gggataagcc tggaagcgac agtgggacat cattttatcc gatctgttct accagagggt   1800
 cctgttggac acagcgggaa gctcttcagt ggagacgagc tattggaagt aaatggcata   1860
 actttacttg gggaaaatca ccaagatgtg gtgaatatct taaaagaact gcctatagaa   1920
 gtgacaatgg tgtgctgtcg tcgaactgtg ccacccacca cccaatcaga attggatagc   1980
 ctggacttat gtgatattga gctaacagaa aagcctcacg tagatctagg tgagttcatc   2040
 gggtcatcag agacagagga tccagtgctg gcgatgactg atgcgggtca gagtacagaa   2100
 gaggttcaag cacctttggc catgtgggag gctggcattc agcacataga gctggagaaa   2160
 gggagcaaag gacttggttt tagcatttta gattatcagg atccaattga tccagcaagc   2220
 actgtgatta taattcgttc tttggtgcct ggcggcattg ctgaaaagga tggacgactt   2280
 cttcctggtg accgactcat gtttgtaaac gatgttaact tggaaaacag cagtcttgag   2340
 gaagctgtag aagcactgaa gggagcaccg tcagggactg tgagaatagg agttgctaag   2400
 cctttacccc tttcaccaga agaaggttat gtttctgcta aggaggattc ctttctctac   2460
 ccaccacact cctgtgagga agcagggctg gctgacaaac ccctcttcag ggctgacttg   2520
 gctctggtgg gcacaaatga tgctgactta gtagatgaat ccacatttga gtctccatac   2580
 tctcctgaaa atgacagcat ctactctact caagcctcta ttttatctct tcatggcagt   2640
 tcttgtggtg atggcctgaa ctatggttct tcccttccat catctcctcc taaggatgtt   2700
 attgaaaatt cttgtgatcc agtacttgat ctgcatatgt ctctggagga actatatacc   2760
 cagaatctcc tgcaaagaca ggatgagaat acaccttcgg tggacataag tatggggcct   2820
 gcttctggct ttactataaa tgactacaca cctgcaaatg ctattgaaca acaatatgaa   2880
 tgtgaaaaca caatagtgtg gactgaatct catttaccaa gtgaagttat atcaagtgca   2940
 gaacttcctt ctgtgctacc cgattcagct ggaaagggct ctgagtacct gcttgaacag   3000
 agctccctgg cctgtaatgc tgagtgtgtc atgcttcaaa atgtatctaa agaatctttt   3060
 gaaaggacta ttaatatagc aaaaggcaat tctagcctag gaatgacagt tagtgctaat   3120
 aaagatggct tggggatgat cgttcgaagc attattcatg gaggtgccat tagtcgagat   3180
 ggccggattg ccattgggga ctgcatcttg tccattaatg aagagtctac catcagtgta   3240
 accaatgccc aggcacgagc tatgttgaga agacattctc tcattggccc tgacataaaa   3300
 attacttatg tgcctgcaga acatttggaa gagttcaaaa taagcttggg acaacaatct   3360
 ggaagagtaa tggcactgga tattttttct tcatacactg gcagagacat tccagaatta   3420
 ccagagcgag aagagggaga gggtgaagaa agcgaacttc aaaacacagc atatagcaat   3480
 tggaatcagc ccaggcgggt ggaactctgg agagaaccaa gcaaatcctt aggcatcagc   3540
 attgttggtg gacgagggat ggggagtcgg ctaagcaatg gagaagtgat gaggggcatt   3600
 ttcatcaaac atgttctgga agatagtcca gctggcaaaa atggaacctt gaaacctgga   3660
 gatagaatcg tagaggtgga tggaatggac ctcagagatg caagccatga acaagctgtg   3720
 gaagccattc ggaaagcagg caaccctgta gtctttatgg tacagagcat tataaacaga   3780
 ccaaggaaat cccctttgcc ttccttgctg cacaaccttt accctaagta caacttcagc   3840
 agcactaacc catttgctga ctctctacaa atcaacgccg acaaggcacc cagtcagtca   3900
 gagtcagagc cagagaaggc tccattgtgc agtgtgcccc caccccctcc ttcagccttt   3960
 gccgaaatgg gtagtgatca cacacagtca tctgcaagca aaatctcaca agatgtggac   4020
 aaagaggatg agtttggtta cagctggaaa aatatcagag agcgttatgg aaccctaaca   4080
 ggcgagctgc atatgattga actggagaaa ggtcatagtg gtttgggcct aagtcttgct   4140
 gggaacaaag accgatccag gatgagtgtc ttcatagtgg ggattgatcc aaatggagct   4200
 gcaggaaaag atggtcgatt gcaaattgca gatgagcttc tagagatcaa tggtcagatt   4260
 ttatatggaa gaagtcatca gaatgcctca tcaatcatta aatgtgcccc ttctaaagtg   4320
 aaaataattt ttatcagaaa taaagatgca gtgaatcaga tggccgtatg tcctggaaat   4380
 gcagtagaac ctttgccttc taactcagaa aatcttcaaa ataaggagac agagccaact   4440
 gttactactt ctgatgcagc tgtggacctc agttcattta aaaatgtgca acatctggag   4500
 cttcccaagg atcagggggg tttgggtatt gctatcagcg aagaagatac actcagtgga   4560
 gtcatcataa agagcttaac agagcatggg gtagcagcca cggatggacg actcaaagtc   4620
 ggagatcaga tactggctgt agatgatgaa attgttgttg gttaccctat tgaaaagttt   4680
 attagccttc tgaagacagc aaagatgaca gtaaaactta ccatccatgc tgagaatcca   4740
 gattcccagg ctgttccttc agcagctggt gcagccagtg gagaaaaaaa gaacagctcc   4800
 cagtctctga tggtcccaca gtctggctcc ccagaaccgg agtccatccg aaatacaagc   4860
 agatcatcaa caccagcaat ttttgcttct gatcctgcaa cctgccccat tatccctggc   4920
 tgcgaaacaa ccatcgagat ttccaaaggg cgaacagggc tgggcctgag catcgttggg   4980
 ggttcagaca cgctgctggg tgccattatt atccatgaag tttatgaaga aggagcagca   5040
 tgtaaagatg gaagactctg ggctggagat cagatcttag aggtgaatgg aattgacttg   5100
 agaaaggcca cacatgatga agcaatcaat gtcctgagac agacgccaca gagagtgcgc   5160
 ctgacactct acagagatga ggccccatac aaagaggagg aagtgtgtga caccctcact   5220
 attgagctgc agaagaagcc gggaaaaggc ctaggattaa gtattgttgg taaaagaaac   5280
 gatactggag tatttgtgtc agacattgtc aaaggaggaa ttgcagatgc cgatggaaga   5340
 ctgatgcagg gagaccagat attaatggtg aatggggaag acgttcgtaa tgccacccaa   5400
 gaagcggttg ccgctttgct aaagtgttcc ctaggcacag taaccttgga agttggaaga   5460
 atcaaagctg gatccagtac atctgagtca ctggaaagta gctcaaagaa gaatgcattg   5520
 gcatctgaaa tacagggatt aagaacagtc gaaatgaaaa agggccctac tgactcactg   5580
 ggaatcagca tcgctggagg agtaggcagc ccacttggtg atgtgcctat atttattgca   5640
 atgatgcacc caactggagt tgcagcacag acccaaaaac tcagagttgg ggataggatt   5700
 gtcaccatct gtggcacatc cactgagggc atgactcaca cccaagcagt taacctactg   5760
 aaaaatgcat ctggctccat tgaaatgcag gtggttgctg gaggagacgt gagtgtggtc   5820
 acaggtcatc agcaggagcc tgcaagttcc agtctttctt tcactgggct gacgtcaagc   5880
 agtatatttc aggatgattt aggacctcct caatgtaagt ctattacact agagcgagga   5940
 ccagatggct taggcttcag tatagttgga ggatatggca gccctcatgg agacttaccc   6000
 atttatgtta aaacagtgtt tgcaaaggga gcagcctctg aagacggacg tctgaaaagg   6060
 ggcgatcaga tcattgctgt caatgggcag agtctagaag gagtcaccca tgaagaagct   6120
 gttgccatcc ttaaacggac aaaaggcact gtcactttga tggttctctc ttgaattggc   6180
 tgccagaatt gaaccaaccc aacccctagc tcacctccta ctgtaaagag aatgcactgg   6240
 tcctgacaat ttttatgctg tgttcagccg ggtcttcaaa actgtagggg ggaaataaca   6300
 cttaagtttc tttttctcat ctagaaatgc tttccttact gacaacctaa catcattttt   6360
 cttttcttct tgcattttgt gaacttaaag agaaggaata tttgtgtagg tgaatctcgt   6420
 ttttatttgt ggagatatct aatgttttgt agtcacatgg gcaagaatta ttacatgcta   6480
 agctggttag tataaagaaa gataattcta aagctaacca aagaaaatgg cttcagtaaa   6540
 ttaggatgaa aaatgaaaat ataaaataaa gaagaaaatc tcggggagtt taaaaaaaat   6600
 gcctcaattt ggcaatctac ctcctctccc caccccaaac taaaaaaaga aaaaaaggtt   6660
 ttctaatgaa aatctttaaa aatactgtca gtattttaaa attttcaaca gtattataaa   6720
 aacattgcat ctccccacct ctaatatgca tatatatttt tcctgctaaa attggtttct   6780
 acaattgagt aaatggcaaa tacatgaagc aatgtcccta aattttataa agaaattata   6840
 tttaatgcac atttcaattt tcattcttat ttttgacctt ttataaaata ttttcatgtt   6900
 gctataagta aatgatgatg ccaccccatg ttgactatgg tttttctaga aagcaactat   6960
 gctgctaacc atagaggaac atagaagggt tccagaatct ttagtgctgg ttttaacaac   7020
 cgatgcaaca ttaaaaatgt gttagtgtgc tgtgcaattg gttttcaatt catattaatc   7080
 ttaatgacag agaacaatgt gttactaatt attttggttg tatgccatta gtaaattgat   7140
 agaaaaatta aggggattaa cataacttca tttcattgcc ttatattaac atcttataat   7200
 acaatagttt aagactaagg gaaacagatg gagctgttta ttgagacaac tggtgaggaa   7260
 ttatcatgtg ttcattccca ttttagagcg tgaaactcct acattagaat atataaagtc   7320
 actttaaata tctatatttg taacagaagt agtgtacaga tattttatta cagcattttt   7380
 gtgtaaatgc agaattaaag tgaataaata agaattttca gtggtgccca aaaaaaaaa    7439



      <210> 2337
      <211> 3467
      <212> DNA
      <213> Homo sapiens


      <400> 2337
 gggaaaagag taaacgcgcg actccagcgc gcggctacct acgcttggtg cttgctttct     60
 ccagccatcg gagaccagag ccgccccctc tgctcgagaa aggggctcag cggcggcgga    120
 agcggagggg gaccaccgtg gagagcgcgg tcccagcccg gccactgcgg atccctgaaa    180
 ccaaaaagct cctgctgctt ctgtaccccg cctgtccctc ccagctgcgc agggcccctt    240
 cgtgggatca tcagcccgaa gacagggatg gagaggcctc tgtgctccca cctctgcagc    300
 tgcctggcta tgctggccct cctgtccccc ctgagcctgg cacagtatga cagctggccc    360
 cattaccccg agtacttcca gcaaccggct cctgagtatc accagcccca ggcccccgcc    420
 aacgtggcca agattcagct gcgcctggct gggcagaaga ggaagcacag cgagggcccg    480
 ggtggaggtg tactatgatg gccagtgggg caccgtgtgc gatgacgact tctccatcca    540
 cgctgcccac gtcgtctgcc gggagctggg ctacgtggag gccaagtcct ggactgccag    600
 ctcctcctac ggcaagggag aagggcccat ctggttagac aatctccact gtactggcaa    660
 cgaggcgacc cttgcagcat gcacctccaa tggctggggc gtcactgact gcaagcacac    720
 ggaggatgtc ggtgtggtgt gcagcgacaa aaggattcct gggttcaaat ttgacaattc    780
 gttgatcaac cagatagaga acctgaatat ccaggtggag gacattcgga ttcgagccat    840
 cctctcaacc taccgcaagc gcaccccagt gatggagggc tacgtggagg tgaaggaggg    900
 caagacctgg aagcagatct gtgacaagca ctggacggcc aagaattccc gcgtggtctg    960
 cggcatgttt ggcttccctg gggagaggac atacaatacc aaagtgtaca aaatgtttgc   1020
 ctcacggagg aagcagcgct actggccatt ctccatggac tgcaccggca cagaggccca   1080
 catctccagc tgcaagctgg gcccccaggt gtcactggac cccatgaaga atgttcacct   1140
 gcgagaatgg gctaccggcc gtggtgagtt gtgtgcctgg gcaggtcttc agccctgacg   1200
 gaccctcgag attccggaaa gcatacaaag ccaagagcaa cccctggtgc gactgagagg   1260
 cggtgcctac atcggggagg gccgcgtgga ggtgctcaaa aatggagaat gggggaccgt   1320
 ctgcgacgac aagtgggacc tggtgtcggc cagtgtggtc tgcagagagc tgggctttgg   1380
 gagtgccaaa gaggcagtca ctggctcccg actggggcaa gggatcggac ccatccacct   1440
 caacgagatc cagtgcacag gcaatgagaa gtccattata gactgcaagt tcaatgccga   1500
 gtctcagggc tgcaaccacg aggaggatgc tggtgtgaga tgcaacaccc ctgccatggg   1560
 cttgcagaag aagctgcgcc tgaacggcgg ccgcaatccc tacgagggcc gagtggaggt   1620
 gctggtggag agaaacgggt cccttgtgtg ggggatggtg tgtggccaaa actggggcat   1680
 cgtggaggcc atggtggtct gccgccagct gggcctggga ttcgccagca acgccttcca   1740
 ggagacctgg tattggcacg gagatgtcaa cagcaacaaa gtggtcatga gtggagtgaa   1800
 gtgctcggga acggagctgt ccctggcgca ctgccgccac gacggggagg acgtggcctg   1860
 cccccagggc agagtgcagt acggggctgg agttgcctgc tcagaaaccg cccctgacct   1920
 gggtcctcaa tgcggagatg gtgcagcaga ccacctacct ggaggaccgg cccatgttcc   1980
 tgctgcagtg tgccatggag gagaactgcc tctcggcctc agccgcgcag accgacccca   2040
 ccacgggcta ccgccggctc ctgcgcttct cctcccagat ccacaacaat ggccagtccg   2100
 acttccggcc caagaacggc cgccacgcgt ggatctggca cgactgtcac aggcactacc   2160
 acagcatgga ggtgttcacc cactatgacc tgctgaacct caatggcacc aaggtggcag   2220
 agggccacaa ggccagcttc tgcttggagg acacagaatg tgaaggagac atccagaaga   2280
 attacgagtg tgccaacttc ggcgatcagg gcatcaccat gggctgctgg gacatgtacc   2340
 gccatgacat cgactgccag tgggttgaca tcactgacgt gccccctgga gactacctgt   2400
 tccaggttgt tattaacccc aacttcgagg ttgcagaatc cgattactcc aacaacatca   2460
 tgaaatgcag gagccgctat gacggccacc gcatctggat gtacaactgc cacataggtg   2520
 gttccttcag cgaagagacg ggaaaaaaag tttgagcact tcagcgggct cttaaacaac   2580
 cagctgtccc cgcagtaaag aagcctgcgt ggtcaactcc tgtcttcagg ccacaccaca   2640
 tcttccatgg gacttccccc caacaactga gtctgaacga atgccacgtg ccctcaccca   2700
 gcccggcccc caccctgtcc agacccctac agctgtgtct aagctcagga ggaaagggac   2760
 cctcccatca ttcatggggg gctgctacct gacccttggg gcctgagaag gccttggggg   2820
 ggtggggttt gtccacagag ctgctggagc agcaccaaga gccagtcttg accgggatga   2880
 ggcccacaga caggttgtca tcagcttgtc ccattcaagc caccgagctc accacagaca   2940
 cagtggagcc gcgctcttct ccagtgacac gtggacaaat gcgggctcat cagccccccc   3000
 agagagggtc aggccgaacc ccatttctcc tcctcttagg tcattttcag caaacttgaa   3060
 tatctagacc tctcttccaa tgaaaccctc cagtctatta tagtcacata gataatggtg   3120
 ccacgtgttt tctgatttgg tgagctcaga cttggtgctt ccctctccac aacccccacc   3180
 ccttgttttt caagatacta ttattatatt ttcacagact tttgaagcac aaatttattg   3240
 gcatttaata ttggacatct gggcccttgg aagtacaaat ctaaggaaaa accaacccac   3300
 tgtgtaagtg actcatcttc ctgttgttcc aattctgtgg gtttttgatt caacggtgct   3360
 ataaccaggg tcctgggtga cagggcgctc actgagcacc atgtgtcatc acagacactt   3420
 acacatactt gaaacttgga ataaaagaaa gatttataaa aaaaaaa                 3467



      <210> 2338
      <211> 438
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> misc_feature
      <222> (1)...(438)
      <223> n = a,t,c or g


      <400> 2338
 gggtcgaccc acgcgtccgg tgcgggaaag agaccatggt gaccagcacc acagagtcca     60
 gtcgctgcga gtacctcatg gagctgatga cgccagccgc ctgcccggag ccaccgcctg    120
 aagcacccac cgaagacgac catgacgagc tctagctgga tgggcgcaca ggtgggcggg    180
 gaggtggagt ctcgtcggcc tgccccagca aggggaggcg gcgggccctg aggaagatgg    240
 acccacatgg ccactctatc aacctgtgtc cccatgttcc ctgnnnnnnn nnnnnnnnnn    300
 nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn    360
 nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnncgtc tctactaana atacccanna    420
 nnnnnnnnnn nnnnnnnn                                                  438



      <210> 2339
      <211> 4341
      <212> DNA
      <213> Homo sapiens


      <400> 2339
 tttttttttt ttttgatgag caataaaatt cacatgttct ttatttagtc catatgatac     60
 accgtttttt agagtttttg aaaattagat aaaagagcat attaaatggc aagtgtatga    120
 agtttctctt cataaacaat gtcaaaacaa aaagttttga attacaaaat gttaaaaaat    180
 atgtcggtac ttaacagttt cactaatgca taaagttaca gatattttct aaagaaaaat    240
 aattgtgcca cttacctata tttgctgttt ctatgaactt ttttattctg tacataggac    300
 attttgtaca aaatatgaag tctacatttt tattacttat taccataaaa caaagataca    360
 atgtatgtac aatattaaaa ggaagccata ctaaagccac actaaaaaga cacttggaat    420
 agtgacattt ctgatgtaca gatacatttt ggaaagagtg aagatgccaa acgcagaact    480
 ttatgaagaa aaacagtcac cggtttattt tcaatgtagt acttttgaaa tcagtttggt    540
 acagaataaa cagtctctat acaatgatat gtaagctgac aattagcaca ggagtccgag    600
 tactaactag ggaaacttta ggaggccaaa atattaagta atactcttgc caaagaaaat    660
 tagtttctct gaaaactttt atttttcttt ttggtgagtg tttgtcttca ataaagagca    720
 gaaagaaaac ctagacaaaa agatgttctt acacactgag ctttacacag tcacccaaac    780
 attgatattt tgctttttcc cgagggcaaa aagagagtct tcccagaaac ctctctcaca    840
 aacatactga acatccaaaa tcaaggatat ttgagaatct atcagctaaa gacggaagtt    900
 caaacaatgg tatatcaaaa tacataagac gctgctttat acaataaaaa gcaccctttt    960
 tccctcaaaa ggagaaggca tctaaactgt tttttttaat gatagttttc ataatggtaa   1020
 aatggagaga tacttgtcaa gtttctcagg aagtattcat ctcacaaagc ggacttgtcc   1080
 acttttagct ggggcaatct tcgcatttca tacctgcact tgctcttacc acaagaagtc   1140
 ccctcccccc aggtgatttt cctccaagac acgaggacag aagcattgcc agtggcttga   1200
 agtgacagca gtgggcagca ggtaccagag ctgcacaagg agcagtgtct gcttttcact   1260
 atctttgaaa ggatacccga gacctcgatg aaaaaacaga tcctaaaata agccacattt   1320
 tgtcttttat gcctcaagac acttaacatt aagttatata atcttatgcc agagatgaaa   1380
 gaaactagat cacgtgttta gaatagcagt acacatctca agtagctttc aagcaggata   1440
 aataagtcaa aatactggcc accctgagag aaataaagaa tagacaaagc actaagttta   1500
 aagatttttc tccttgtgct attccatcta aaacaaaagc tcagtacatg caaggaactc   1560
 tgtggaatat atagcagcat gtgaagaccg atgaaaactc agacactgta ttttccttac   1620
 aaggtgttga taacgtgagc tcttttcaac agaaagagct ccactaaacg tcatcctcgc   1680
 tggtgcctcc tccaagctct cagaacagca ctgcagcctt cagtgaaggc agcggcagtg   1740
 ccggccccgt gcaatgctgt tgtgttactt tatgcttaaa gggcgcctgc cagtttgcca   1800
 ttaggcctaa agaactggcc ttaaactcaa aatgattttg cctcctaact ttcccataaa   1860
 atgtgggaat tcttaggaga ctataatttt attaattcaa gagccttgtt gaagggcaac   1920
 aatgtttaag ttgacggaaa cgaaatctgc aaataaaaat attaacacat aattttaaaa   1980
 ctccaatttc tgtcaaggta gacagagcaa gctcttttaa gataaatttc agagcaatct   2040
 cttttaaaat aaatctcttc tacaggctta ctcctggaat cctggagtac cacagacttg   2100
 gaaatatggc tttaggtaca cacaagagaa ggagacacgg tgttcatgtc actcatcaaa   2160
 gtgaagagac cccttagaaa ataccagcgg ctgaggattg tcatttgccc agtacgttgc   2220
 gtgagaactc gaaagcaaag agccatttca ctgagattga aaaacaaaca aaagaactgc   2280
 tggcgtaaca atcacgtgga aaccatttca aaggctgtaa agtcttaaaa aataggtcct   2340
 attttttaaa gcgttccttt gatttggaaa acactgatgt tatcacagaa ccacctatgt   2400
 taaaagatcc taagttccat ttgggagaac atgaagatga agggcagggt gctttcctat   2460
 cgctctgact ttgtgaaata gtctgacttg gactacgctg gggtggcggc gacactgcga   2520
 ggacaccgtc gtcaacccgc ggctctgcca gcgggctctg ggaagtcacc attgtttgaa   2580
 ctcctaatct cgcgctgagg cggacgcacg ttattgccta cggaacgggg tccaagaaag   2640
 ctttgagtgt aactgattgg tatggcacag gaagtatgta ttttctacag aatccggaaa   2700
 agaactggcg ggcccggccc cgacgcggcg ccccggaggc tagcggccgt cctgggaggc   2760
 cagctcatcg gccctgcagt gagcttccaa ggctttcttg gtgtgggggt cctgaggcag   2820
 ctcggacttg cggagtgcaa gaggacggtc cttcttcgga tctttctgtg cctgatgagc   2880
 ctcgtccttc actgtctttc tcagcatctg cacatcttca aataaaggcc catctgtctc   2940
 cattgcaacc ggaatgctca tggtgctggc ttgactatac actgtgtact ggggattggc   3000
 tttggctaga ttttctattt taacccatgc ttcttcccgt tctttcattt ttagcttctc   3060
 ttttagtttc tctgctttga actgttgtgt acagtcatca aatagctttt ggttcatctc   3120
 catgaagagc ttcagggcgt tgtatatcaa gccatgtatt gtcttgttcc aatgggtctt   3180
 tgagttgcgg tacaaggaag gaaacatgat gggcagaatc ttcgctgcgt tgtcactgat   3240
 taaactcatg atgtattcat tattcccagt aatagagagc tcgctctgcc acctggaagt   3300
 gtgggcttgg agacacattt ggccaactgc cggaagaggg gttccatgat cttcacaaat   3360
 tctgatggtt caatgacatc taaaatctct tctaattcgt ttaagaacat tacttctttt   3420
 ggactgtgag tctttggcca gtatttgaga agtgccatca ccactggttc cgtgagggtg   3480
 ctgtcctttt ctaaaaactg cactacacag tatgccagct ggggatggta gacactcaga   3540
 gatttcactt tgtgcaaagg tagtaacacc ttcaataaga aaatcttgtg ctcttctttt   3600
 agtggtaagg caaatccatt aattatactt cccaatattt ccagtaactc tgctatgcca   3660
 ttatgatgct ctgtttcata aataaaccta taaaatatat tatttatctg ttttctgatg   3720
 taagctctca agcctaggaa tttcccatag attctgtgaa gggtggtttt aagaaaatct   3780
 ctctcccgag gatcttcact gtcaaagagc tctaaaagct gcaatacaaa cttctgatca   3840
 atatatttct tcgctatatt aggttggaaa tctggagact ctaaaaatct ttaggaaaaa   3900
 ttcataaaca agctgtagat gaggccaggc tgcttctaac gttggttcat cttcctccgg   3960
 gtcaaattcc gctcccgtag gattggagga aggtggtaat gttcgaaaca tgttaactgc   4020
 aaacatatgg actacttctg ggtaaatagg ctctgtgatc acattccgat tatgggtgat   4080
 atattctacc atttcactta aagcagctcg ttttacttcc ttccacttta ggtcacttag   4140
 tggatcagaa acaaagtcaa agaggacgca acactgacgt aacttctgga taaaaagctt   4200
 ctcttgatca gcaggaggaa catctcgaat atggagaagg accacgggct ggaaaggccc   4260
 attggagttg gccgcatcca ccaccatcct gctgcccgct ttattacatg tcaacatcta   4320
 gacttcagcg ggaaaggcaa t                                             4341



      <210> 2340
      <211> 945
      <212> DNA
      <213> Homo sapiens


      <400> 2340
 tttttttttt ttcactagcc acaaacattt attgttgggg tcaatacgta tatccttttg     60
 agaagtgttt cgagccattc atttgataac tacaaacacg tcagaatctg ttttactggt    120
 atatttttgg cttgcatgac aagggaaaag agattattgc aaaattatga atgaagtcca    180
 aaaggcctga ttaaaaaaaa atctataaaa tggaaggatt aaacactgcc cagccctact    240
 gtgtcaacaa agacggtaca attcaaatca agaagacaat cccatacaag tccagcaagg    300
 cagatgttgg caagtagaag ttaagcaatc tgttatacaa aatgcaaaag gagttaaaga    360
 taaattacaa aaaataaaaa acaaaatttt agtcagaaaa ctattactac ataaagccat    420
 ataagaatgt gtattagttg tttcctttaa gggaaaagga aatcaaactg ttggttttct    480
 atttattcag aagaaaaaat aaaggaaagt gtttggaaaa tatttctgat attaagtgaa    540
 ttatttctca tctgctacct agagtttaca aacaactgac ttatccttgt caatctgtgg    600
 aaatgagaaa ataaaatcag cgtctggcct tcgtgggata ctcataacac ccgaatgagg    660
 tccagagtaa tcctagatcg ggggatgtca atgttgagta cttggacttc cactctttct    720
 ccggggccca gtccaaggct tcttctcttc tttgtttttg aaagttttgc ttctgttaca    780
 tttcgtatgg gaatcagccc agatttcccc actcctatat ccacaaaaat tccaaagaga    840
 gtggcattct caactttgcc tgtaagaact gtcccaatct gcagatcttc caggcatact    900
 atgcttctct tgaaatcagg tttatcaaaa tctgttcgaa agtca                    945



      <210> 2341
      <211> 442
      <212> DNA
      <213> Homo sapiens


      <400> 2341
 agcggtgcaa ttcccgtgcc tcggtctgca cctctgtgaa acgggaaaat acccgccatg     60
 ggccgttgtg gttttaaatg agatcctgca gggaggcccc gatctgctgt ctatcaacaa    120
 acttactgag aagggaggcc ccgatctgtt gtcaatcaac aaacttactg agaagggagg    180
 ccccgatctg ttgtcaatca acaaacttac tgagaaggga ggccccgatc tgctgtcaat    240
 caacaaactt actgagaagg gaggccccga tctgctgtca atcaacaaac ttactgagaa    300
 gggaggcccc gatctgctgt caatcaacaa acttactgag aagggaggcc ccgatctgtt    360
 gtcaatcaac aaacttactg agaagggagg ccccgatctg ctgtcaatca acaaacttac    420
 tgagaaggga ggccccgatc tg                                             442



      <210> 2342
      <211> 1890
      <212> DNA
      <213> Homo sapiens


      <400> 2342
 gggatccgcg acccgcacac taacctctta aggaactaca ttcaagacca gatagagctt     60
 gaaccagatc gaaggatcac cagtttccct cgaagtccga gtccacctgt cggatcatgt    120
 ccggagcttg atgtaaatat cttctggagg gccccgggaa ctggggctaa aaatgatcat    180
 tgtccccggt agccagcttt cgcaactgcc gccaggactg gatagcaccg agtttgcagc    240
 cattgtgggc aatttacttg ataacgcctt cgaagccagc ctgcgtagcg atgaaggaaa    300
 caagatcgtt gaattattcc tcagcgatga aggcgatgat gtggtgattg aagtcgccga    360
 tcagggctgc ggcgttccag agtctctacg agacaaaata tttgagcagg gggtcagtac    420
 gcgtgctgac gagcccggtg aacatggcat tgggttgtac ttgattgcca gctacgtaac    480
 gcgctgcggt ggtggtatca ctctcgaaga taatgatccc tgcgctccat taaccctatt    540
 gatcgttgag gacgaaacgc cgctggcaga gatgcatgcg gaatatattc gtcacattcc    600
 cggattcagt cagatattac tggcgggaaa tctggcgcag gcccgaatga tgatcgagcg    660
 ttttaagccg gggctaatct tgctcgataa ctatcttcct gacggtagag ggattaattt    720
 actgcatgaa ctggtgcagg cgcattatcc cggcgacgtg gtgtttacca ctgcagccag    780
 cgatatggaa acggtgtctg aagccgtacg ttgtggtgta tttgattatc tcattaagcc    840
 cattgcctat gaacggctgg ggcaaacgct aaccgggttc cccccagcgt aaacatatgt    900
 tgaaaagtat tgaaagcgcc acccagaagc aaattgatga gatgtttaat gcttatgctc    960
 gcggtgaacc taaggacgag ctaccgaccg gcattgaccc cttgacgcta aacgcggtgc   1020
 gaaaactgtt taaagagcct ggtgtgcaac atacggcaga aacggtggcg caggcactga   1080
 ccatcagccg caccactgcc aggcgttatc ttgaatattg cgccagccgc catctgatta   1140
 ttgctgaaat tgttcacggc aaagttggca gaccacaacg catataccac agtgggtgac   1200
 atgataaagc cggaggaaac ttgcctccgg cattactatt tacttgcctg tgaccgctgc   1260
 tgccgttcct ggcaccatca gctctgtagc aacgataaca atcaccaaac caacaagcac   1320
 cggtaccgag gtgcgtttta cgacttcaaa cggcgagatc ttcgccatcc cggcaaccgc   1380
 aacgactacg ccagaaacgg gcgaaagggc tctttgatga tagcctatga tcacaatgct   1440
 tatgtaaaac cactctggct ttatctggtg attgatcagt tccaacagcc ccatagagct   1500
 gtgggtttcc tgtttcatat tttgcaaggg gcatttttaa aaaaggtctt ttctatcaac   1560
 cagtatgaaa atgcgacccg cgatatcgcc gtgctggaag atgccggcgt accgtatcag   1620
 ctgctggaat ccagccgcct ggcggaagtg gagcccgcgc tggcagaagt ggcgcacaaa   1680
 ctgacgggcg gcctgcagtt acccaatgat gaaaccggag actgtcagct atttacccag   1740
 aatctggcgc ggatggcgga gcagccgggg gttaaattcc gcaataatac gcccgtgacc   1800
 aatcatacga ctttgagctc ggtaccccat gctacgccag gcatcggcat tgccaacggc   1860
 aatagcgatg cgatcggcta tgtgttgtag                                    1890



      <210> 2343
      <211> 461
      <212> DNA
      <213> Homo sapiens


      <400> 2343
 agccagttct tggaggagac tctgcacagt gcatggatca ctgtggtgcc cttttcctgt     60
 gcctgtgcct tctgactttg cagaatgcaa caacagagac atgggaagaa ctcctgagct    120
 acatggagaa tatgcaggtg tccaggggcc ggagctcagt tttttcctct cgtcaactcc    180
 accagctgga gcagatgcta ctgaacacca gcttcccagg ctacaacctg accttgcaga    240
 cacccaccat ccagtctctg gccttcaagc tgagctgtga cttctctggc ctctcgctga    300
 ccagtgccac tctgaagcgg gtgccccagg caggaggtca gcatgcccgg ggtcagcacg    360
 ccatgcagtt ccccgccgag ctgacccggg acgcctgcaa gacccgcccc agggagctgc    420
 ggctcatctg tatctacttc tccaacaccc actttttcaa g                        461



      <210> 2344
      <211> 1718
      <212> DNA
      <213> Homo sapiens


      <400> 2344
 ctctgaagca ccattcaaat tacggcgtag cacccgccat ccgcgaattt ggatatatac     60
 accaccagtt cccggataat attccgctga ctttatacct tgcggaagcc tatcgccatt    120
 ttggtcatga tgaccgggct cgtctgttgc ttgaggatca actgaaacgt cacccaggag    180
 atgcccgact tgagcgcagt ctggcggcta ttccggttga agtgaaaagc gttacgacag    240
 ttgaagaact gcttgcccag caaaaagcgt gcgatgctgc tccgaccctg cgttgtcgca    300
 gtgaagtcgg gcagaatgcc ctgcggctgg cacagttacc tgtcgccaga gcgcaactga    360
 acgatgcgac gtttgctgca tcgccggaag gattttactc tgcgaaccga tctgctgcaa    420
 cgggcaatct acctgataca atgctggacg atcggatcct ggcactgcaa tcacagggga    480
 tcttcaccga tcctcagtca tatattactt acgcgaccgc gctggcttat cgtggcgaaa    540
 aagcacgcct ccagcattat ctcattgaaa ataagccact atttaccacg gacgcacaag    600
 agaaaagttg gctctatctg ttatctaaat acagcgctaa ccccgttcag gcgttggcga    660
 attatacggt acagtttgcc gacaaccgcc agtatgttgt tggcgcgacg ctaccggtgc    720
 tgttaaaaga aggtcagtac gacgcagcgc aaaaactgct cgccaccctc cccgccaatg    780
 aaatgcttga ggagcgttat gctgtcagcg tggcgacccg taacaaggct gaagctctgc    840
 gtctggcacg attgctgtat ccccaagaac cggcaaatct tacccgcctg gatcaactaa    900
 cctggcaact gatgcagaac gagcagtcac gcgaagctgc cgatttattg ctgcaacgct    960
 atcctttcca gggcgatgcg cgtgtcagcc agactttaat ggcgcgactg gcgtctctgc   1020
 tggaaagtca tccttacctg gcaacgccgg cgaaggtggc gattttatcg aaacccttac   1080
 cgctggcgga gcaacgtcag tggcaaagtc agttgcgggc gaccagtgca caaccggttc   1140
 ccggtccgac gcccgtcgcc aacggttcta ttttccagtc tgctcagccg attaactatg   1200
 gctatcaacc gctgtttgaa gatcgtcgac cacgcaatat tggcgatacg ctgaccatcg   1260
 tgttgcagga gaacgtcagc gccagcaaaa gctcctctgc gaatgccagc cgtgacggta   1320
 aaactaattt tggctttgat actgtgccgc gctatttgca ggggctgttt ggtaacgctc   1380
 gtgccgatgt cgaagcctcc ggtggtaaca cgttcaacgg aaagggcggg gccaatgcca   1440
 gcaatacctt tagcggcacg ttgacggtga cggttgacca ggtactggtc aacggcaacc   1500
 tgcatgtggt gggtgaaaaa cagattgcca ttaatcaggg taccgaattt attcgcttct   1560
 ctggcgtggt taatccacgc actatcagcg gcagcaatac cgtaccgtct actcaggtgg   1620
 cggatgcgcg cattgaatac gtaggcaatg gctacattaa cgaagcgcaa aatatgggct   1680
 ggttgcagcg tttcttcctt aacctgtcgc caatgtaa                           1718



      <210> 2345
      <211> 2697
      <212> DNA
      <213> Homo sapiens


      <400> 2345
 atgcgggcag gattcacaag taacgtcctg accttcctga cgtgcacgag tcacttcctc     60
 aacaccttcc gggctgctga cgtggcaaac gtgcagacgg caaccagcaa ctttcgccag    120
 atacaagtct ttgaagacat catcacgcaa tacaatggca aatatatcct cgcagtagaa    180
 ggtaatccgc cgctgggcga gcaggggatg ttctgtatca gcagcggtcg accgtttatt    240
 gagaaactca aacgtgccgc tgccggagcc agcgcgatta tcgcctgggg aacctgcgcg    300
 tcctggggct gcgtgcaggc cgcgcgaccc aatccgacgc aggcaacgcc tatcgacaaa    360
 gtcatcaccg acaaacccat tatcaaagta cctggctgcc cgccgatccc ggatgtgatg    420
 agcgccatca ttacttacat ggtgaccttt gatcgcttgc cagatgtcga cagaatgggc    480
 cgtccgctga tgttctatgg tcagcgaatc cacgataaat gctatcgccg cgcccacttc    540
 gacgccggag agttcgtcca gagttgggat gatgacgctg cccgcaaagg ttactgcctg    600
 tacaaaatgg gctgcaaagg gcctaccacc tataacgcct gttcctcaca cgctggaatg    660
 atgggtctgg tcacggctgc tggctggcgg aaatggtttg gatcggggtc gtttcagcgg    720
 tgtcgattcg agttggataa gctatctatc cagcgccatc agcgttacca tggcaccagc    780
 tacaaccttg aaccagacat caaaagcagc cctggcggct tgcgcgatat ccacactctg    840
 caatgggtgg cccgccgtca ttttggcgca acatcgctgg atgaaatggt cgggtttggc    900
 ttcttaacct cagcggagcg ggcggaatta aacgaatgtc tgcatatatt gtggcgtatt    960
 cgctttgccc tgcatctggt cgtcagccgt tacgataatc gcctgttatt cgatcgccag   1020
 cttagcgtcg cccagcgtct gaattacagt ggtgaagtga actcaaccag atgctgctgc   1080
 aactgttcga tgaaaccatc ctcgcccttt ccgccgacaa aaaaccaccg tccaatcgac   1140
 gatgagttta agctacgcgg tacgctaatc gacctgcgtg atgaaaccat tattatgccg   1200
 ccagccggaa gccatcttgc gtatgttctc caccatgggg cacaacaggg cgacaaccgc   1260
 ttttactcca ccacgttggc ccatttcgcc atgcccgtgg cctttggaaa caccgttgtg   1320
 tatattccgg aagcccaaaa ctgttttgag catcttggtc accccggtga gcgacttagc   1380
 tctaaagatt ttttctacga cgacggtgag tttgccgcca ttcttgagga tgtgcgcacg   1440
 gtccgcgaat taggttttcc tggactggtg acgggcgttc tcgatgttga cgggaatgtc   1500
 gatatgccac gaatggaaaa aataatggct gctgccggtc cgctggcagt gacttttcat   1560
 cgcgccttcg atatgtgcgc taacccttta tatacactca ataatcttgc ggaattgggc   1620
 attgcccggg tactgacatc agggcaaaaa tcagacgcac tgcaaggttt atcaaaaatt   1680
 atggaactta ttgcccatcg tgatgctcca atcattatgg ccggagcagg agtccgtgca   1740
 gaaaacctgc accacttcct cgatgccgga gtgctggaag tccatagctc cgcgggagcg   1800
 tggcaagcct caccgatgcg ttatcgtaat caaagattgt ccatgtcatc agatgaacac   1860
 gcggaccagt attcgcgtta tatccctgcg tctgacatct acgaagacga aggcatttta   1920
 atgatcaccc cagcggcaac cgcgccggag ctgaccgccc gtggctatca gctgatcctg   1980
 cgcaccaccg gcctggactc cgaccagggg ccgacggcgg cgaaatatat tcttgagaaa   2040
 gtgaaaccgc agcgtattgc tatcgttcac gacaaacagc aatacggcga aggtctggcg   2100
 cgagcggtgc aggacggcct gaagaaaggc aatgcaaacg tggtgttctt tgatggcatc   2160
 accgccgggg aaaaagattt ctcaacgctg gtggcgcgtc tgaaaaaaga gaatatcgac   2220
 ttcgtttact acggcggtta tcacccggaa aggggcaaat cctgcagccg gcaacaaccg   2280
 tcatttccat tgagcccgcc aatcctgatg tggtctatat tcccaactac aacccaaccg   2340
 tggtttacgg gaactgggcc aatactgcgt atccgtcggt ttatctgcca ccaccagcct   2400
 gagaaccgtt tgttgacagc tttgtacgcg gattcggcta tagcatgggc gttgctacca   2460
 cgtacgcact attcagcagc atcgactggg acgacgacaa tcatgaccat catcatcatg   2520
 acaatgatga ttatcatcac cacgatggcg gtcatcgtga cagtcatggc tggcaacaca   2580
 acaggcgaca acattaaaat cgacatcaac caaattcaac ccgatcaccc cgggaaccat   2640
 cttactcgaa aagaaatatg gcattggcgg gacaaatcca aactaaccgc aatgggg      2697



      <210> 2346
      <211> 6516
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> misc_feature
      <222> (1)...(6516)
      <223> n = a,t,c or g


      <400> 2346
 atgaaaatta atcgtattgt taatgaggga tttatgaaaa cgatgctggc agcttattta     60
 ccaggaaatt cgaccgtcga tctgcgggaa gttgcggtgc cgacgccggg gattaaccag    120
 gtactgatca aaatgaaatc ctccgggatt tgcggaagcg atgtccacta tatctatcat    180
 caacaccgtg ccacagcggc ggcacccgat aaaccgttat accagggctt tatcaacggt    240
 catgaaccgt gcgggcagat tgtggcgatg gggcaaggct gccgccattt taaagagggc    300
 gaccgcgtgc tggtgtatca catttctggc tgtggttttt gcccgaactg ccgtcgcggt    360
 tttcctattt cttgtactgg cgaaggaaaa gcggcttacg gctggcagcg tgacggcggt    420
 catgccgaat acttgctggc ggaagacaaa gatctgatcc tcctgccgga tgcgctgagc    480
 tacgaagatg gtgcgtttat cagttgcggc gttggtacag cgtatgaagg aattttgcgc    540
 ggcgaagttt ccggcagtga taacgtgctg gtggtcggtc tgggcgcagt cggcatgatg    600
 gcgatgatgc tggcgaaagg tcgcggtgca aaacggatca tcggcgttga tatgctgccg    660
 gaacgtcctg gcgatggcaa aacatttggc cacggtcact tttcccaaca cgaacccgat    720
 gaacttggaa tgatatggcc ccccgccagt tcgtccccac tattgattcc ggatgtgcct    780
 tctccgtata ccccatgttt atcggaaagc tgccaacgta tggttatcgt cgggtatggg    840
 cgttgcttcg cagacaggca gaacttgatg ggtatgcctg cgatcaatgc caaacgtgtt    900
 taccggatca tgcgccagaa tgcgctgttg cttgagcgaa aacctgctgt accgccatcg    960
 aaacgggcac atacaggcag agtggccgtg aaagaaagca atcagcgatg gtgctctgac   1020
 gggttcgagt tctgctgtga taacggagag agactgcgtg tcacgttcgc gctggactgc   1080
 tgtgatcgtg aggcactgca ctgggcggtc actaccggcg gcttcaacag tgaaacagta   1140
 caggacgtca tgctgggagc ggtggaacgc cgcttcggca acgatcttcc gtcgtctcca   1200
 gtggagtggc tgacggataa tggttcatgc taccgggcta atgaaacacg ccagttcgcc   1260
 cggatgttgg gacttgaacc gaagaacacg gcggtgcgga gtccggagag taacggaata   1320
 gcagagagct tcgtgaaaac gataaagcgt gactacatca gtatcatgcc caaaccagac   1380
 gggttaacgg cagcaaagaa ccttgcagag gcgttcgagc attataacga atggcatccg   1440
 catagtgcgc tgggttatcg ctcgccacgg gaatatctgc ggcacgggct tgtttccttc   1500
 ataagctcct tacaaaagtt catcaatgat tttgctttcg aagacggtct gttcagcggc   1560
 tacgacgctg aaaaacgtca atacgaaaaa tcgtcctgga actatcagct cgatgaaaac   1620
 ggctatgcga aacgcgatga aacactgact catccgcgct gtccaaaagc cgacttcctg   1680
 aaagtgtgtg aagtgctggc ctccaccagc gcaccggatc gcacaaccac cttcctgtac   1740
 gcgctgggct ggacgcagca cactgtgggt gcgcagaaca tccgtactat ggcgatgatc   1800
 cagttgctgc tcggtaacat gggtatggcc ggtggcggcg tgaacgcatt gcgtggtcac   1860
 tccaacattc agggcttgac tgacttaggc ctgctctcta ccagcctgcc aggttatctg   1920
 acgctgccgt cagaaaaaca ggttgatttg cagtcgtatc tggaagcgaa cacgccgaaa   1980
 gcgacgctgg ctgatcaagg tgactactgg agcaactatc cgaagttctt cgttagcctg   2040
 atgaaatctt tctatgagcg atgccgcgca gaaagagaac aactgggggc tttgactgcg   2100
 ttgccgaagt gggataaagg ctacgacgtc ctgcaatact tcgagatgat gaaagagggc   2160
 aaggtcaatg gctatatctg ccagggcttt aaccctgttg cctcattccc gaacaagaac   2220
 aaagtgatcg gttgtctgtc gaaactgaag ttcctcgtca ccatcgaccc actgagcact   2280
 gagacctcta acttctggca gaaccacggt gagctgaacg aattgactcg tcgaagatcc   2340
 agaccgaagt gttccgtctg ccatcgacct gcttcgcgga agagaacggt tctatcgtta   2400
 actcaggtcg ctggttacag tggcactgga aagatgtatg ccgaacaggg tggcgcgaac   2460
 ccggaccagg tgctgaacat gacatggaac tacgccattc cgcatgagcc atcttcagaa   2520
 gaagtggcga tggagagcaa cggtaaggcg ctggccgata ttaccgatcc ggcaaccgag   2580
 cgcgacttcg acgccattcg ccctgtcttc ttttctactt ctcagcttgg ccaggctgcg   2640
 ccgtcttttg gcggaaccac tggcacactt caggatgcct ttgatctgga ggcgctaaag   2700
 gccctcgata tcattgtgac ctgtcagggc ggcgattata ccaacgaaat ctatccaaag   2760
 cttcgtgaaa gcggatggca aggttactgg attgacgcag catcgtcttt gcgcatgaaa   2820
 gatgacgcca tcatcattct tgaccccgtc aatcaggacg tcattaccga cggattaaat   2880
 aatggcatca ggacttttgt tggcggtaac tgtaccgccg cttccggcgg tggtgcgcga   2940
 catatgcgtg agttattaac ccagatgggc catctgtatg gccatgtggc agatgaactc   3000
 gcgaccccgt cctctgctat tctcgatatc gaacgcaaag tcacaacctt aacccgtagc   3060
 ggtgagctgc cggtggataa ctttggcgtg ccgctggcgg gtagcctgat tccgtggatc   3120
 gacaaacagc tcgataacgg tcagagccgc gaagagtgga aagggcaggc ggaaaccaac   3180
 aagatcctca acacatcttc cgtaattccg atgtgtctat tccgaccgtg gaagaactgc   3240
 tggctgcgca caatccgtgg gcgaaagtcg ttccgaacga tcgggaaatc actatgcgtg   3300
 actaacccca gctgccgtta ccggcacgct gaccacgccg gacgtgtgcg aaaaaccggc   3360
 cagcaccacg ctttggctgg atgttgggcg gacagtggac tggatctgac ctatcagacc   3420
 ctgaatgtga agaatgacct gtcacacttc ccggtgccat tctttgaccc gagcgataac   3480
 cgcaccaaca ccttgccgat ggtctttgcg ggtgcgccgg atgttgggct gcaacaagcc   3540
 tctgccattg tcgcctcgtg gtttggttcg cgttctggct ggcgtgggca gaacttcccg   3600
 gtactctata accaactgcc ggatcgcaat gccattgtct ttgcaaccaa cgacaaacgg   3660
 ccggacttcc tgcgcgatca tccggcggta aaagccccgg tgattgagat gattaaccat   3720
 ccgcagaatc cttacgtcaa actgctggtg gtgtttggtc gtgacgacaa agacctgttg   3780
 caggcagcga aaggtatcgc tcagggtaac attctgttcc gtggtgaaag cgtggtagtg   3840
 aatgaagtga aaccgctgct accgcgtaag ccgtacgatg cgccgaactg ngcccacagg   3900
 agagcaacaa tgacaatcca taagaaaggt caggcacact gggaaggcga tatcaaacgc   3960
 gggaagggaa cagtatccac cgagagtggc gtgctgaacc aacagccgta tggatttaac   4020
 acgcgttttg aaggcgaaaa aggaaccaac cctgaagaac tgattggcgc agcgcatgcc   4080
 gcatgtttct caatggcgct ttcattaatg ctgggggaag cgggattcac gccaacatcg   4140
 attgatacca ccgccgatgt gtcgctggat aaagtggatg ccggttttgc gattacgaaa   4200
 atcgcactga agagtgaagt tgcggtgccg ggtattgatg cctctacctt tgacggcata   4260
 atccagaaag caaaagcagg atgcccggtc tctcaggtac tgaaagcgga aattacgctg   4320
 gattaccagt tgaaatcgta aagcattgcc ggatgacgcg tcaggcgcgt gaatgcgtcc   4380
 gtcctccctt attgctaatg attgccggac ttcacatccg tgggttgcca gcgggcaacg   4440
 ttcgtagaaa aaacagcctt gcggcaacgt gcggtttccc ggcagatccg ttttacgtaa   4500
 tgcccattct tcctccagcg gtttatcaat ggcggggagg gaatccagca ataatcgggt   4560
 gtatggatgt gcaggtgccg tcagcacctg ctgcgcgtcg cccagttcta caatctgccc   4620
 gagatacatc accgccaccc gatcgctcat atgacgtatc accgagacat tgtgtgaaat   4680
 cagcacatag gtcagcccgt gattttcctg tagcgttacc agtaaattga ggatctgcgc   4740
 ctgaacggag atatccagcg cagaggttgg ctcatcaagc acaatcacgt caggctgcga   4800
 agagagtgct ctggcaatgg cgatacgttg ccgctgcccg ccggagaacg catgaggcag   4860
 gcggtgcggg ttgccaccgg tacaaacatc atccagtgcc gcctgcgcca gtgccggaat   4920
 gtcttccttg cgtacaccaa catcacgcaa atgtggcgtg gtcgcgctcg gaccgtagca   4980
 tttgcgcgag gtcacatgtg ccaccagctc agcgggcgtg gcatcctgca actctgcggt   5040
 agaagcgtta ccggtcgcca gacctgcggc ttttgccatt tccagaatcg ttgggtgatc   5100
 tttttcgtga atatcgacgc ccagcgcgcc gttataggtt ttgacaccgg ttgaccaggc   5160
 ggttgctgat gcagccgagt cggtgacgta gtccggtttg ccggtttttt tattcagcgc   5220
 atagtgagtg tattgcccgg taagcggtaa ggcatctata cctttaaaaa agccgcccgc   5280
 accttcggca taattacgtg cggcagtaat ttccgagtcc cccatcccat cgccaatcag   5340
 caaaataata ttttttgcag gtttatcgcc gttaaacggc gaacaataac cgcgcagctc   5400
 ttcgccgttg tggctgttca ctttttcttc ataagtacgg aagtagccgt tcagtgccgg   5460
 acgaccaaat tcgttgttaa acgccgcgcc gcccagcggg ccttcggtca tgatgtccag   5520
 cgcggtgaca atgcgctcag gcttaccgaa atcttcttcc cacggcatcg atacccagtc   5580
 ggcgttaaaa attttgtggc ggcagtgctc ggagttcgcc tgggcaaaca tatacagttc   5640
 gatgtcgttc gggttacgac caagctttgt gaaagcatcc tgcagatagt caatttcatc   5700
 ttccgccaga gccaagccaa gacgcaggtt agcgtcgatc agcgcctgac ggccctgccc   5760
 cagcaaatca acgctggtaa ccggagtcgg ttgatggtgg gcaaacaact gctctgcatc   5820
 atctaaagca aaaaagaccg tttccatcat gcggtcgtgc agttcagcgg taacctgctg   5880
 ccattgttca ttggtcagcg taccggcttt atgcggatgc cattcgttat aatgctcgaa   5940
 cgcctctgca aggttctttg ctgccgttaa cccgtctggt ttgggcatga tactgatgta   6000
 gtcacgcttt atcgttttca cgaagctctc tgctattccg ttactctccg gactccgcac   6060
 cgccgtgttc ttcggttcaa gtcccaacat ccgggcgaac tggcgtgttt cattagcccg   6120
 gtagcatgaa ccattatccg tcagccactc cacgctcctc atgagctgcg tctgtatgtg   6180
 cgtgaactgc gtgaccgtag tcgtactgtc gatgagctga accgtactat cgatcagctg   6240
 tgccgtgaaa acgacatcaa cattgccttt aaccagcttg aagtgcatct gcacaacgag   6300
 aagggcgatg aggtgacgga agtaaaacgc gaccgcttca atctttttgg cggcaaaacg   6360
 cccatggaac accgctttgc cgccgcccgc tggcagacgg gggtgaccgg atgcccgcaa   6420
 ctggaagagg ctctggtttc gtttgactgc cgtatcagcc aggtggtgag cgtcggcacc   6480
 cacgacattc tgttttgcgc catcgaagcg attcat                             6516



      <210> 2347
      <211> 698
      <212> DNA
      <213> Homo sapiens


      <400> 2347
 ctttatgcct gccgccgact ctagaggatc aggcttatgg cgaggctctt atacccctcc     60
 gcaacaccct taccgcggta cacgtcaaat aagtttacgc caactacctg atttacgcca    120
 actttcttac attcggataa aatatccgct gcgggaacgt tttctgcgac caccaccgcg    180
 atgtcacgac ggttcgccgg gaagcgagaa atctcgcgcg cctgaggcac cacgcggtct    240
 gcgagcttgt tccactccag ttcgaacacc agagtgcgac cgttaagatc cagtttacgt    300
 tccagttcag gatgaacaac cccaacaaaa ccaatacgtt cacctttcag ataaatcgct    360
 gcggattgcc ccggatgcag tgccggattc gcttctgcac ggaactcaac ctcattcagt    420
 ttaccggtca ggtcgagaac ggattcaaga tcgcctttca aatcatagaa atcaacggtc    480
 tcttttgcca ggttccagtg ctcttcgtaa cggttaccgc aaatcacacc ggctaacatc    540
 agatcctgac gaatgcccaa cggtgcctga gtatctggta cgaaacgcag accgctttcg    600
 aaaatgcgca cacggttctg ctgacggttc tggttgtaca ccacggttgc cagcaggcca    660
 gtccacagag aaagacgcat tgctgacatt tcaacaga                            698



      <210> 2348
      <211> 888
      <212> DNA
      <213> Homo sapiens


      <400> 2348
 atggatcctg aacacgccaa acctgagtca tccgaggcac cttcagggaa cttgaaacaa     60
 ccggagactg ccgcagccct ggcaagtagc ggcagcgtag tgagttctgt acccaaggca    120
 cagcgcaaca tctcagcgaa gaccgcaccc cggaagcacc ccgcagtctc aattcgcagt    180
 gcgcagtccg cagccgccgc acgtccccaa ggcagtgagg gcaccgcacc ctcaaggaaa    240
 gccaccacac gcccaccccc aaagcccaca ctcccacccc ccacgccctc tgcacacact    300
 gaatccaaac tcttaaatga gatggcgatc aaagagcgcg tggagggccg agccaaagtc    360
 ccgtacaaat tcagggacag cctcaaacgt ttctccttct cgcccactgg aatgttgaag    420
 atcctgagac tggtgagcgg agagctgatc ttggccctga ttgcattcat ctgcatagag    480
 accatcatgg catgctcccc gtgtgaaggc ctctactttt ttgagtttgt gagctgcagt    540
 gcgtttgtgg tgactggcgt cttgctgatt atgttcagtc tcaacctgca catgaggatc    600
 ccccagatca actggaatct gacagatttg gtcaacactg gactcagcgc tttccttttc    660
 tttattgctt caatcgtact ggctgcttta aaccatagag ccggagcaga aattgctgcc    720
 gtgatatttg gcttcttggc gactgcggca tatgcagtga acacattcct ggcagtgcag    780
 aaatggagag tcagcgtccg ccagcagagc accaatgact acatccgagc ccgcacggag    840
 tccagggatg tggacagtcg ccctgagatc cagcgcctgg acacgtga                 888



      <210> 2349
      <211> 838
      <212> DNA
      <213> Homo sapiens


      <400> 2349
 ttaggtgagg aagagtttag ttattatttt ccaggaaggc aatgaaaggc acagactgca     60
 tatccaaaac ccagtggact gtataagaca atatcctcca gggcccagtg aagcgtaata    120
 gctccgagac agctactgat aattcaaatg acaaaagcca tagcatgaaa tacaggcctt    180
 gggcagcagc atctaaaaat aggaggtcct caggcatctc gggcaagatg gccacacttc    240
 tgttggcggt ggtcactccc catctacatt cccataacat gggcacatgc gggtactaca    300
 cccacactgc taccttgtgg agttctgttt cttcccctgg ggcactgggt tcttacaggg    360
 ggacattgga ttgctcagca actcctgtta ctagcactgg tcctcattaa tattttgcat    420
 ctctggatgt atgctgctcc acgtaggaac cactgcacac gtggctgtcg agcacttgat    480
 aggtggtgtc caggatgatg aggacttaga aatgaccata ggatgtcatg gtgaagagat    540
 gattggtgac cttgataaga acagttttgg cgctggtggt ttgtgcatcg gagagagagt    600
 aggagggcct gggtgctgtg aagtcctaat tagaatgact ccaacagagg atgtgggaga    660
 agagaggtct gacatgaagg gaatacaact gagcatgcaa gagaggacca gatgtagaca    720
 atttcctgaa ggaaggagac atcagctggg ccacctgctt cagggaggcc tgggaagagg    780
 ggaggcttgg aaatatcacc agatttggga agaaggtcac tggctattga gggagcag      838



      <210> 2350
      <211> 312
      <212> DNA
      <213> Homo sapiens


      <400> 2350
 atggaagggt caagaatgaa ataccgcatc gctttagctg tttctctctt tgctcttagt     60
 gccggtagtt atgccactac cctgtgtcag gaaaaggagc aaaatatcct taaggagatc    120
 agctatgccg aaaaacacca aaaccagaat cgtattgacg gtctgaataa aaccctgagt    180
 gaaatccggg ccaactgttc agatagccag ctgcgtgccg atcatcaaaa gaaaaacgca    240
 aagcagaaag atgagggggc ggaacgccag caaaatttag ccgaggcgaa acaaaaaggc    300
 gatgccgatt ag                                                        312



      <210> 2351
      <211> 3321
      <212> DNA
      <213> Homo sapiens


      <400> 2351
 atggatatca tttctgtcgc cttaaagcgt cattccacta aggcatttga tgccagcaaa     60
 aaacttaccc cggaacaggc cgagcagatc aaaacgctac tgcaatacag cccatccagc    120
 accaactccc agccgtggca ttttattgtt gccagcacgg aagaaggtaa agcgcgtgtt    180
 gccaaatccg ctgccggtaa ttacgtgttc aacgagcgta aaatgcttga tgcctcgcac    240
 gtcgtggtgt tctgtgcaaa aaccgcgatg gacgatgtct ggctgaagct ggttgttgac    300
 caggaagatg ccgatggccg ctttgccacg ccggaagcga aagctgcgaa cgataaaggt    360
 cgcaagttct tcgctgatat gcaccgtaaa gatctgcatg atgatgcaga gtggatggca    420
 aaacagttta tctcaacgct gctgttgtat aaaggagacg ttatgcagga tttaatatcc    480
 caggttgaag atttagcggg tattgagatc gatcacacca cctcgatggt gatgattttc    540
 ggtattattt ttctgaccgc cgtcgtggtg catattattt tgcattgggt ggtactgcgg    600
 accttcgaaa aacgtgccat cgccagttca cggctttggt tgcaaatcat tacccagaat    660
 aaactcttcc accgtttagc ttttaccctg caggggatta tcgtcaatat tcaggcggta    720
 ttctggctgc aaaaaggcac cgaagcggca gatattctga ctacctgcgc gcagttgtgg    780
 atcatgatgt atgcgctgct ttcagtcttc tcgttgctgg atgttatttt gaatctggcg    840
 cagaaattcc cggcagcatc tcagttaccg ctgaaaggga tatttcaggg gattaaactg    900
 atcggcgcga ttctggtcgg cattttgatg atctcgctgc tgattgaggg ttacatcacc    960
 gtgcaggggc gcgagaaaga tcagattaac cgtggcggcg agaagatcgc tgccgaagag   1020
 atcgaaaacc tgctgctgcg ccacccggcg gtgatctacg ccgcactggt gagcatggaa   1080
 gatgagctga tgggcgaaaa aagctgcgct tatctggtgg taaaagagcc gctgcgcgcg   1140
 gtgcagaata aagttgactg ggcctttgaa ccgcaacgtg ccgcgttgtt aatccatgat   1200
 atgcaggact attttgtcag cttctggggc gagaactgcc cgatgatgga gcaggtgatc   1260
 gcgaatattg ctgcgctgcg cgactactgc aaacagcaca atatcccggt ttattacacc   1320
 gcccagccga aagagcagag cgatgaagat cgggcgctgt tgaatgatat gtgggggccg   1380
 ggcctgaccc gctcgccgga acagcaaaag gtggtggatc gcctgacgcc agatgccgac   1440
 gacacggtgc tggtgaagtg gcgctacagc gcgtttcatc gttctccgct ggagcaaatg   1500
 ctgaaagaga gtggacgtaa ccagctgatt attacgggac taactcagca gagagcagtt   1560
 ctaataaggc tgacaacaag acagagctat cgtgcaggaa ccacaattgg cgcatgcatg   1620
 ctggcaatgc cgctagctgc ggccggtgta ggttttagcg ttacgttaat cttgttgatt   1680
 gggctttggg cgttgatgtg ctacacggcg ctattactgc tggaggtgta ccagcatgtt   1740
 ccggcagata ccggtctggg cacgctggca aaacgctatc tgggacgcta cggtcaatgg   1800
 ctgacgggct tcagtatgat gttcttaatg tatgctctga ctgcggcata catcagcggt   1860
 gccggtgaat tgttggcctc cagcatcagc gactggacag gtatttctat gtcggcaacc   1920
 gctggcgtgc tgttgttcac ttttgttgcc ggtggcgtgg tttgtgtcgg aacttcactg   1980
 gtcgatttat ttaaccgttt tctgttcagc gccaagatta tttttctggt ggtaatgctg   2040
 cgttcaaata ccgttggtgg acggttgcaa actggtgcaa ttacgtttct gccgccgttg   2100
 gcgtttgcac tgttttatcc acgaggattt gtgatggcgc tgggttacgc cggtgtggcg   2160
 ctggcggtac tggcattgat tatcccttcg ctgttgacct ggcaaagcag aaagcacaat   2220
 cctcaggcgg gttaccgggt caaaggtggt cgtccggcgc tggtggtggt tgatcaggaa   2280
 gttgaacgtt ttctgagcgg tcgtgccaag gcatcagccc agctggaaac gatcaaaacg   2340
 aaagctggtg aaacgttcgg tgaagaaaaa gaagccatct ttgaagggca tattatgctg   2400
 ctcgaagatg aggagctgga gcaggaaatc atagccctga ttaaagataa gcacatgaca   2460
 gctgacgcag ctgctcatga agttatcgaa ggtcaggctt ctgccctgga agagctggat   2520
 gatgaatacc tgaaagaacg tgcggctgac gtacgtgata tcggtaagcg cctgctgcgc   2580
 aacatcctgg gcctgaagat tatcgacctg agcgccattc aggatgaagt cattctggtt   2640
 gccgctgacc tgacgccgtc cgaaaccgca cagctgaacc tgaagaaggt gctgggtttc   2700
 atcaccgacg cgggtggccg tacttcccac acctctatca tggcgcgttc tctggaacta   2760
 cctgctatcg tgggtaccgg tagcgtcacc tctcaggtga aaaatgacga ctatctgatt   2820
 ctggatgccg taaataatca ggtttacgtc aatccaacca acgaagttat tgataaaatg   2880
 cgcgctgttc aggagcaagt ggcttctgaa aaagcagagc ttgctaaact gaaagatctg   2940
 ccagctatta cgctggacgg tcaccaggta gaagtatgcg ctaacattgg tacggttcgt   3000
 gacgttgaag gtgcagagcg taacggcgct gaaggcgttg gtctgtatcg tactgagttc   3060
 ctgttcatgg accgcgacgc actgcccact gaagaaagac agtttgctgc ttacaaagca   3120
 ttggctgaag cgtgtggctc gcaagcggtt atcgttcgta ccatggacat cggcggcgac   3180
 tatgagctgc catactatga acttcccgaa agaagagatc cggtttcctc ggctggcgcg   3240
 ctattcgtat cccgatggat cgtagaaaga tcctgcgccg ataagttccg ggtattctgc   3300
 ggtgcttctg gttttcggta a                                             3321



      <210> 2352
      <211> 2415
      <212> DNA
      <213> Homo sapiens


      <400> 2352
 ttactttttc accacaatta acggttcaat atcactctct tttttgatga ccagtgattc     60
 atcaccgcgc aaacacgtcc caccgtagtt gccgccaacg gtgaaggtac atacctgaat    120
 gtatttaccg tccactttca cgcaaccgac aaggtgctga aagatgacaa cctgctggcg    180
 ctgttcgaca tcccgaaaat cctctggcca cgtttgcgtc tctcctggca gcgtcgccgt    240
 caccatatga tcactggtcg tatggatttc tgctataggt tgtcgattat ggttggcggt    300
 gatgaagcgg tatttgaacg tgttaaaccg ctgtttgaac tgctcggtaa aaatatcacc    360
 ctcgtgggcg gtaacggcga tggtcaaacc tgcaaagtgg caaatcagat tatcgtggcg    420
 ctcaatattg aagcggagcc cacgtatctg cgaaagcggg taccggtatc gatgaactgc    480
 ttggacgcta tcctgctgca ggcggaagtt ctggagctga aagcggtacg taaaggtatg    540
 gcgagcggtg cggttatcga atccttcctc gataaaggtc gtggtccggt tgctaccgtt    600
 ctggtacgtg aaggtactct gcacaagggc gatatcgttc tgtgtggctt cgaatacggt    660
 cgtgttcgtg cgatgcgtaa cgaactgggt caggaagtgc tggaagcggg tccgtccatt    720
 ccggtggaaa tcctcggcct gtccggcgta ccggctgcgg gtgatgaagt taccgttgta    780
 cgtgacgaga agaaagcgcg tgaagttgca ctctatcgtc agggtaaatt ccgcgaagtt    840
 aaactggcgc gtcagcagaa atctaaactc gagaacatgt tcgccaacat gaccgaaggc    900
 gaagttcacg aagtgaatat cgtcctgaag gcagacgtac agggttctgt cgaagcgatc    960
 tccgactcct tgctgaaact gtctactgac gaagttaaag tgaagatcat cggttctggc   1020
 gtaggtggta tcaccgaaac cgacgccaca ctggctgcgg cgtccaacgc catcctggaa   1080
 gggctgttca cgttgacgtt ggatcggtac cgaatcgagg ggtctgttct gggaaaaagt   1140
 cgcatcgtaa tcgacaccgt tgtatgtcac gccgagttga taataacgat cctgcacccc   1200
 cggatagggg tttacccagg cgtagacatg ctcgctttca aagttgccgt tggtattgtt   1260
 gtcacaatag acgggaattt taatatcgtc agattcccag atcttatcac cgggtttggc   1320
 attgcctggt acagcaaacg gttgaatcgc ttctgatttt tctagaagac ctggtgaaaa   1380
 ctgtgccgtt tccagcgcaa tattgtcctg catccattta ccgagccacg gcttcaggtc   1440
 gatgtcatcc gcctggagcc agacgcgacc attgcttaac aacccctcat catcgcgcaa   1500
 atccatgcgc acctgcatca cgccgtgcga tgaagcacgc gatcgtgaat ctggcggtac   1560
 aggtttgggg ctggcgattg ttgaaaccac aatccccagc gtgatggcga cgatttccgc   1620
 agacaatata aaatcggtac gaatcgcccc ttttattttg tccttttcaa acttcagcgg   1680
 atcctgcgca gagccagcag cgtctggaga agctggatag cgttgtcgat cccgttgccg   1740
 cgattgaaaa tgctgagatc gtgattgtcg gcggcgggaa tactttccag ttgctcgcaa   1800
 gatgagtttg tcatcgcgcc cggattctcc accgacccac tggaagaaca gcacagcgta   1860
 gtgtctggtt tgttgcataa ataccacaac cgggcgcttt tgctggtcaa aggcggctgc   1920
 gcggtaaatt gccgctattg cttccgtcgt cacttcccct atgccgaaaa tcagggcaac   1980
 aagcgtaact ggcaaactgc acttgagtat gttgctgcgc atccggaact ggacgagatg   2040
 attttctccg gcggcgatcc gctgatggcg aaagatcacg agctggactg gttgctcaca   2100
 caactggaag atccggttgc cgcggcctcc caaagtgctg ggaatacagg cgtaagccac   2160
 tgtgcccagc tttttctgac tatcttctat gtgtggaata agactgattt tcattttcac   2220
 gggcgaatga tgcccggtga atatgtactt tcttccagct ttggcatcgc aggtcacgat   2280
 attcacgaac tgccgtctgg cggtcgcgat ccgctctcct atgatgatcc attgcgtcaa   2340
 atcacccgca tgatccaaaa attcccgaaa ccgatcattt cgatggtgga aggtagtgtt   2400
 tgggccatcc gccat                                                    2415



      <210> 2353
      <211> 1135
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> misc_feature
      <222> (1)...(1135)
      <223> n = a,t,c or g


      <400> 2353
 ggattcgatc cccttnnnnn ntntaactga tgtncctagt ccgtgtggtg gaattcctct     60
 tggacctggt ggacaggagc tggggcggct gcaggtccct gcacagcaac gaggcattcc    120
 ttgctcaggc aagacacatc ttgtcatctg ttgaagaatt cacagcagct caggacagct    180
 ctgcgatggt gggtgaagat gtcggctccc tggctctgga gagtaagtcc ctgcaaagcc    240
 gccttgctga gcagcagcag cagcacgccc gggagatgag cgaggtgacg gcggagctgc    300
 accacgcaca caaggagctg gatgatttga gacaacattt agataaatct ttggaagaga    360
 acagtaggtt aaaatcgctt ttgttgagta tgaaaaagga agtgaagagt gcagacactg    420
 cagccacgtt aaatttgcag atcgctggac ttcaaacaag tgtgaagagg ctgtgtggcg    480
 agattgtgga actgaagcag cacctggagc actacgacaa gatccaggag ctcacgcaga    540
 tgctgcagga gagccacagc tccctggtca gcaccaatga acacctgctg caggagctga    600
 gccaggtgcg ggcgcagcac agagccgagg tggagcagat gcactggagc taccaggagc    660
 tcaagaagac catggccctg tttccacaca gcagcgccag ccatggaggc tgccaggcct    720
 gctgactcct gccgagaagc tgggccaccc cttaagcttc ctggtaaagt tacattgtct    780
 gcacctttgt acttctttat tgagtgtact ggctggcaag agttctctct tctgttggta    840
 attatttagg atttttggaa tgtattcagg acctgtagct tggttttcta aagcacctcg    900
 taaaatgata tgattactcc aagcccctct gcatgttttc agacagaaca cattgacata    960
 ttttgagaca aactgactat taatcttgta tccagtatcc tgagatgaag taaatgcagt   1020
 gttttactgc ctgatgtgaa agagagctat gtatgataat taaagaaaat aattttctgt   1080
 gtaacaagca atctttattt aataaacaaa taacattgtt ttgaaaaaaa aaaaa        1135



      <210> 2354
      <211> 363
      <212> DNA
      <213> Homo sapiens


      <400> 2354
 cctggcgttg ctttgcctgg gcggtgcaga caagcgcctg cggatctttt gccataaatg     60
 agggcatact ggcctgacgt aatttactcg tttgccaatc gcagccgctt ctggaagcat    120
 gagtgggaaa agcatgggac ctgcgccgcc caggtggatg cgctcaactc ccagaataag    180
 tactttggca caagcctgga actctacagg gagctggacc tcaacagtgt gcttctaaaa    240
 ttggggataa aaccatccat caattactac caagttgcag attttaaaga tgccctcgcc    300
 agagtatatg gagtgatacc caaaatccag tgccttccac caagccagga tgaggataga    360
 cag                                                                  363



      <210> 2355
      <211> 2119
      <212> DNA
      <213> Homo sapiens


      <400> 2355
 tttttttttt ttgcaggttt agaaaataaa gtttgttggg atcttaaaca ttttggataa     60
 aactaacaaa aaaatatgaa cacacattca ggttgtggtg ctatgaggag tagcgtcatc    120
 ttatttagtt ccttgagata cacgcacggc tgctcggtga tcggtgccgc cctgggaaag    180
 gttggtcagg aggtgacagg ggtctccagg aggagctcgg gaggtgacaa gggtctccag    240
 gagggagcag gggctgctcg gccaggctgc cctggagctt gaggataagg tcaaggttgg    300
 tatgtgttgc tccgacttga gaatgaatta ggtgtgtgac tgtgtggcat cgtgaacatc    360
 agtagtgacg cagccgtggc ctgggctttg cctgcagcgc acttaggtta cacggagcgg    420
 gatcagaagc aagcgattcg gcacacaggc gtttggccac agcaattagg aaatacatat    480
 tctgcggcag ggacacgatc atattttggt gtgaagaaga gggcaagaga agcagaagga    540
 gaatgggtcg gtaggtgtga aaagtgtttg gcatgcatgg gattaaacag aaaaggtgtg    600
 gctgagattt cccagtggtg ctcacagtgc atggacagcg cggggtgggg cacggcgggc    660
 ttcacacagt tctgtccgtc cctgagtgct tcctcaccac cttgcctccg ttcacctggt    720
 cgaccgccag ggtcttcacc tcgggctggg cctgcggcgg ggtggcgtgg tggatccgat    780
 gtgccacccc gacgtgggcc ttgtgcggct tttcgcgggc cgggctgtgc tgctcgccgc    840
 ttcggtcgga ggcgatgggg gggatgacga ggggcctctc tttgatgagg tggacctcgg    900
 cggactccct agccagcaga aatggggtgg ggtcgggcat agcatccact ggttcccgca    960
 aaaggagttt cctgctctct gccccgaatc tgtagacctc ttcaaattcc gggtgcaagg   1020
 gggctgagag gctctttttc atgcggcggc gaggcgtttc gggtagcttg tctttggggg   1080
 gcgctggctt gtagctggcc agcacggggc tccctgacgg gctggcatct gaggtcccgc   1140
 tggagctcat gagcttcttc ttggcggcgt gcagctggga ggtcaggtag gcgatggtgc   1200
 tggcccgctg ctccagctcg ctagacagca gggtcagctt gtgactcttg gccttcagct   1260
 cctccaggta cttcttctct cgctccttga tggtgttctc cagcactgtg atcatcgcgt   1320
 ttttctgctc cagttctttc aacaactcag cattttcgtt ctctttcact ttcagttggg   1380
 cttccagctc ttcacatctt ttctttaatt cactgctttt agaagtcccg tctcctgtct   1440
 gttccgaact tttgactgtc agctcatatg ttaaatctgt gcagtgctgc tgcagccgcc   1500
 tgatctcgga gtgcagcccc ttgagcgtgc tggcatgctc ccgctgaagg aacaggaggt   1560
 tcttctgtgc gctgtgcagc tggttctcca ggtttgtggc tgccatgctg acatccagag   1620
 gaccttcatc gtaactcgag aaatgtggtg aagtcatggg tctttctgga aaagctacca   1680
 gagtaattca agacgcttgt acagcactga aaaatactga ggatgaaatg tgagttattt   1740
 gcttataaat tattattgta aatacagaac ctcagaatgc attttcccta atttgctatt   1800
 ccagagaacc ctccgtaaag gaggtacaac ttctcaatgg ctcccaggac gcagcccatt   1860
 tgtaggatgc cacagtggaa ccgttttgga gacactgaca cacccaggct gtcactgctt   1920
 cagacgacac caattgctca tcaattatct gtacgaccag tgacatgcat gcacactagc   1980
 tctggagcta ggacgagttc ataacgaact tcagacatac actttcatca cacgaaaaca   2040
 cttcctgggc gctgctccgg tggaaagcca cagactccac tccgagggca acctgagaac   2100
 gcagagaagg aaataaaac                                                2119



      <210> 2356
      <211> 4797
      <212> DNA
      <213> Homo sapiens


      <400> 2356
 tttttttttt ttaaagttta aacacctttt atttgaagaa atattgcttc tagactttcc     60
 tgaagccaga attgttctat aaaagtatca tggaatatta tacatgatta aaaaacagag    120
 tatgcttcct aataacttga aatcttttta caaagcacat tattcatgat cataaatatg    180
 tttgttctgt catcccaccg atgatacaca catcaggcaa gcagctaatt tgaacatatg    240
 tacagagtct atgataaaga tttaaagtta ccaaaaagat tcagctataa catattaaat    300
 tttctttaaa agagtttacc ataaacactt aaagaaaaca taatttatct aagcacttga    360
 attatctaaa aataagaaga aaacctctct tagggtaagc aaaaacacat catcttgggg    420
 agctgaataa aagggtactg atgactcagt gaggtaatcc ctttagctgg tatttaaaaa    480
 cctaatacac aacaaggata ttttcaagaa tacagatttt caaaagcaat tttgaactat    540
 gtctttaaaa gatatcagaa cttggtgaag gtcttacaaa taatcataga acacaatgtt    600
 aagaaattaa cttctcttgt ggtatgttga aattgtggag cattcatgat tttcttttat    660
 tgagaagttc ttggtgtaaa ttcaaaacta gtcatatttt atcaacattt aagcttctta    720
 gtcatgccaa gaaaaccaaa aaagatgaaa ataaaagatc tttagatctt tttctcctgt    780
 caagaaaata acccaaaata tagcaatctt aaaggtatga tgtatgatga acgctttgag    840
 gctaggcaca gagagagcag gcaatcttca ttttgtttac ttatttattt attttcacca    900
 ccaacattat tagccatgcc tttctgctaa tcgattttag caagtcgagg taaaacacat    960
 gcaacatttt ctggcaaaag cttaatgtca aacaatatgt gatccatact gtgtgtcgtc   1020
 cttgggggtt tatttgactt tgtcacaatg acagccaaca gtgagactga taagcctgta   1080
 aaaataaaaa aataagacta atcaaataga catggcattt taatctcaaa gtgcaaaatc   1140
 atctaactga aaatgacggc attgaaaaat tccagtggtt aaaaatgaat caaaacttca   1200
 ttacgcaggc agtggaagtg tgttgaaaga tttaccaggg gtgtcaagtt ttagacactc   1260
 agaaaggcac cattctagcc atcttgattg gataacatgt atatacttat gtccctacga   1320
 tattcaaaag ataatactgt tttagtacaa aacaaacaaa caagcaaaaa atcaaaacca   1380
 agccaaccca aatatcccca gcctttcttt ctactcttgg cagatagtaa attataacga   1440
 tgagtctccg tgtgcacacc gcttgctcac atgctcacta gcttctactg cacaaaggta   1500
 cccagggtag cttggaatgt tggtggctgt gattaccttt attagtttac aaataaaaaa   1560
 gttaaaaaga aatactgtgt ttagggtaag gtaacagttt ccacctaatc aagaggagag   1620
 tgaaagagga agcgctgcct tcctaggtgc tgtgacttct ccttttcgtg attcttctcc   1680
 accttggtca acatcttccc cgctatgctg gaattacttc ggtgttctgc ggtggccatg   1740
 gtgaacatct gatgaactga aattccatcg gaatgcacag gaagatatag ttgatcttca   1800
 aaaatgtcct ttccaggacc accatactgg ggaagttctt tcgggtgcct gcgaatgggc   1860
 tgcagcctgg ggctgggccc gagctctagc tctgtcatgc catcgccact gaaatcggtt   1920
 tccagatgat tagtctcttc atgccccgtc catttttcgg tttttctcca gtgttcagaa   1980
 ttcaaatgat taacttctgg aatgtcgtta ttccattcaa gtttactctc tggacttaat   2040
 gttggtcggt tcaaatgcag ggtttgaagg tcagctggca aggtcaaatg aggtgttttc   2100
 ccaaccttat gccttgggtc ttcatctgag tcagcagagg ccatctccat tgacacagcg   2160
 tgctcagcag agacaaccaa gaacccgtca ctttgagcag tttgagtctt atttgtttta   2220
 ttttgctcat agtgactctt cagcagtgca aatactctat ctaaatcctt caagtaatta   2280
 gtccagtcca ccagactaag tctgtagttt tgtctgtact catagatgtt ttcattcaca   2340
 ctgtgtagct cctctaggcc ttgccagttg atgtctgcag tgagacgggg ctgattaacc   2400
 ttcccatcca tcccataact gtcctctgtg taggtcatag cttcctccat ctttatttcc   2460
 aacatcaaga ttcttaggtc ttgggttgca ctgcttatat ccttgacagc ttctgagctc   2520
 cattagttgt acgtgtagct gattcaaaat gcctcgttct accgtgtgca ctgtatttgt   2580
 gagctgataa ggatctgtat tcatatcaaa atactccaaa aagccagtag caaactcaca   2640
 gaaaagaaaa ttatgcgtct cattaactgt acgcaaacac cagtaggtgt tattgttaga   2700
 actcgtgcaa gcacagaaag atcccaggtt ccagaacggg gctgtctgcc agtggttgtt   2760
 gtcatgcgtg aagcaagtga ggccaggcag gctgcactct tcccccttcc tctgccgtct   2820
 cttctccttc ctctccttct tcctcctacg gttgttctcc ttgaaaagtt gcagtttgct   2880
 atctacttcc tgagcagcct ccttgaatgg gtgaagatgg ctctttaatt tctcttgctt   2940
 ttttacacct ttctctttat tgtaatagct ttgtttactg cagctacatt cctcaggctt   3000
 ccttctcttc agatgtcctc tcacttctct taaattctta attttatctt gcagagcttc   3060
 aatctcttcg tcaatgtatg ccttatggtc cttccacgct ctggccgatt ggtacagttc   3120
 tctctcacaa tggatagagt cattgggaag aataaaacac ttgtgtgtca ctcggacagt   3180
 ggtaggtggg cccacggcgt tgctgctatc tgccagcatc ctgcccctgt tgccaccact   3240
 ggaagcctgg agatctcttg gccccttgtg gccttcatca tgacgcttag caatgtttct   3300
 tggttgcaac acttgcaatt cttcttcttc ttccagattt atgtcatata tttcaccttc   3360
 aaattcgacg gacaaggaac gtgtctgccg agtatggaca aatctgggct tgtactttgg   3420
 agtcccctgg tttctcaaga attgccgttg actctttctt tggcttctgc tggcacggta   3480
 accagactcc ctacaactgc actctttgtc tttgtcatgg aagccgcgag cgtagaggtt   3540
 ccgcgtgctc tgccggactg tgagcaggtc actgggtcct ttacacttgt gaattcgaag   3600
 cttgccagat gtatcctcaa tgcattgcca cttctgcccc ggttgttcac aggctgtctg   3660
 gtacctggcc tgctggcata gttctttgac ccgttcatat ttgggcaagt gatttgactg   3720
 ttggatattc ttgctggatt cttccttctt acgtagaaat ttgcctcttt ccactaggaa   3780
 tgtatcacgc caaattttgg ccttcttgtt tgttcgaaac ctgttacctg gcttttctgg   3840
 gtccagaagt ttgaggacag acttgccgtc cacatcagga ggtgtgtcga gcccagcaat   3900
 atccaggatc gtgggggcca agtcaatgtt gagaacgatc tgtgggacta ttgatcctgg   3960
 ttctacactt ggaccacgaa taaaaaaagg cacacgaata tcaaagtcat atggcatgga   4020
 tttccccttg accagtccaa actgcccaat atggtaacca tggtcggcgg tgtaaatgat   4080
 gtaagtattc tccagctccc ccgtctccac gagcatgtta tacagcctct ccacagaatc   4140
 atccactgac atcaaagtct ggagcctttt gcgctgtaga atgtttgtaa attccatgtg   4200
 gatgggcagc attggtcctg tgtactgcat aatccagtgt ttatccatat ttggtgcata   4260
 gttataacta ggagttatgt gttgggaagc attggggtac agtttagaaa actgtggggc   4320
 tgagtcctcg gggccgtggg gctcggcgtg gctgatcacc atcataacgg gcctatgggg   4380
 atacattctc ttagacattt tgaagtaatt aatgctctcg ttagtgatta agtctgtgaa   4440
 gtagtccttt gcataatcaa atccatgctt ttctttgatg ccattgcgac aaacagtgta   4500
 attatagaag cgagaattct tgattaatcc aagccattct cgccacccag gggggatgta   4560
 gctgccatta tattcattga ggtattttcc aaaaaaggct gttctgtagc cagtgttgtt   4620
 aagatataca gcaaaagtcc gaggctcatg catggcctgc cacgaggggg aagagcagtt   4680
 ctcgttgttg gtgtagacat tgtgattgtg cacatacttc ccggtgagca tggaggaccg   4740
 tgacgggcag cacatgggtg tagtcacaaa ggcattgatg aaggtggccc ccccatg      4797



      <210> 2357
      <211> 766
      <212> DNA
      <213> Homo sapiens


      <400> 2357
 tttttttttt ttaataaaac cataacaaat ctttcattaa agatctactg agaccttggc     60
 tgaaatcatc tattattgtt gctagttagc ctctcttcta tagttgggta atgtgtgtct    120
 tgccactgtg tttgccagct ctcccaagtg aaaagaacac tttttataaa aaaattaatt    180
 gctccaagtt ttcaggccca ggggaggctc tcccattctc ctccttcaat aagtcccgtc    240
 caggtaagag gtgatcttgt ggataaattc atcatacttc actttgccat tgggttcgat    300
 atctgccttc cctgaagaga tcatcccact tccttgtggg tgagcttctc ccccagactc    360
 gtgagttttg accgcaggtc ggacgccatg acgtaacctt tcttctcctt gtccaccatc    420
 aacatggcta gaagaatttc tttctttggg tcttcttgtt ttatttgcat gtgcataatg    480
 gtcagaaaag tggagaaatc cagctctcca tttccgtcta tcccgtgggt ctgcaggtgc    540
 cgctgcacct cccctggcgt cgggctggcc cccaggcacc tcatggccac catgaggtcg    600
 gtggctttta tcttccccct ctgctgcttg tcatacaggg agaagcattc cttgtactca    660
 ttaatttggt cttgggaaag aaacttggcc attctggggc ctcagctgct acccgtgggc    720
 ttgctgctcc cagaaccgcg ttcagttccc tttcctccct cgtgcc                   766



      <210> 2358
      <211> 765
      <212> DNA
      <213> Homo sapiens


      <400> 2358
 ctccccgtga agtcccatac tacacaatat tcatctggtg ttgttgccta gagtttgtcc     60
 cagcggaggg ttggcttcgg atctgcagag gctttaggga cctgctccag ccactgaaca    120
 cactagccgt ctgagacggc agctgagttg cactgtgcga cgcgacagag actacatttc    180
 ccagcattcc agcggcgcac tcgggggacc acagatccca gcgcaccaca gatcccagcg    240
 caccacaaag aggcccgggg actacaaatc ccagcatccc ctgcactcgg ttcctctgta    300
 acttagactc cagtgtgccg cgcagtgtgc gcaaattcac aaacccgccc gctgagttgg    360
 tcgtttcgga atcccgagac ttgaaaccca acgggaagac ccttctcacc ctcaaaagaa    420
 gatgacagcc cgcagagagt taacttctgt ttacatggaa ctcagacatc tgcaaatcat    480
 gatttcaagg ccagagaatg gcaggggaac agaaaccctc aagtaatctc ctggagcagt    540
 ttattttact agccaaaggt accagtggct cagccctcac tgctctcata agccaggtct    600
 tagaggctcc cggagtgtat gtctttggag aacttctgga gctggccaac gtgcaggagc    660
 ttgcggaagg agctaatgct gcttatttgc agttgttgaa cctgtttgcc tatgggacat    720
 acccagatta catagccaac aaggagagcc tgccagaact gtatt                    765



      <210> 2359
      <211> 495
      <212> DNA
      <213> Homo sapiens


      <400> 2359
 gcggccgcag cggcgtccgt acctccaccc accgggagcc ccttgaagca tcccggaggg     60
 gcttctggcg ctgcaggagc cccgatcggg gagccacagc atccgggagc cgtggtgtct    120
 gtgcgtgcgt ggagcctgtg ctcatgacat aggaagccga acagaaggag cgtcctcaaa    180
 tcctttccta cagtcaccaa acccacgctc tgttaaaatg acatttcgtg gctcctactt    240
 tgtttccccg gagagcaatg agttttctat caggcctgat ttagtttgac aaaagtcaaa    300
 aagaaaaact ggatttgtcc ctctgcgagt tcagtcagat cgctgggaaa acagaaatga    360
 caaaacaata ataacagaaa tagaaccagg catttgatac ataattacca tcaccacggc    420
 tgtcaagctt tctggaatta cgttcctcca gtaactggtg atgatgcttg caggaggcaa    480
 aatgcaatgc agttt                                                     495



      <210> 2360
      <211> 1918
      <212> DNA
      <213> Homo sapiens


      <400> 2360
 ctagcttggc acgaggcggg acgccggcag ggttgtggcg cagcagtctc cttcctgcgc     60
 gcgcgcctga agtcggcgtg ggcgtttgag gaagctggga tacagcattt aatgaaaaat    120
 ttatgcttaa gaagtaaaaa tggcaggctt cctagataat tttcgttggc cagaatgtga    180
 atgtattgac tggagtgaga gaagaaatgc tgtggcatct gttgtcgcag gtatattgtt    240
 ttttacaggc tggtggataa tgattgatgc agctgtggtg tatcctaagc cagaacagtt    300
 gaaccatgcc tttcacacat gtggtgtatt ttccacattg gctttcttca tgataaatgc    360
 tgtatccaat gctcaggtga gaggtgatag ctatgaaagc ggctgtttag gaagaacagg    420
 tgctcgagtt tggcttttca ttggtttcat gttgatgttt gggtcactta ttgcttccat    480
 gtggattctt tttggtgcat atgttaccca aaatactgat gtttatccgg gactagctgt    540
 gttttttcaa aatgcactta tattttttag cactctgatc tacaaatttg gaagaaccga    600
 agagctatgg acctgagatc acttcttaag tcacattttc cttttgttat attctgtttg    660
 tagataggtt ttttatctct cagtacacat tgccaaatgg agtagattgt acattaaatg    720
 ttttgtttct ttacattttt atgttctgag ttttgaaata gttttatgaa atttctttat    780
 ttttcattgc atagactgtt aatatgtata taatacaaga ctatatgaat tggataatga    840
 gtatcagttt tttattcctg agatttagaa cttgatctac tccctgagcc agggttacat    900
 catcttgtca ttttagaagt aaccactctt gtctctctgg ctgggcacgg tggctcatgc    960
 ctgtaatccc agcactttgg gaggccgagg cgggccgatt gcttgaggtc aagtgtttga   1020
 gaccagcctg gccaacatgg cgaaacccca tctactaaaa atacaaaaat tagccaggca   1080
 tggtggtggg tgcctgtaat cccagctacc tgggaggctg aggcaggaga atcgcttgaa   1140
 cccggggggc agaggttgca gtgagctgag tttgcgccac tgcactctag cctgggggag   1200
 aaagtgaaac tccctctcaa aaaaaagacc actctcagta tctctgattt ctgaagatgt   1260
 acaaaaaaat atagcttcat atatctggaa tgagcactga gccataaaag gttttcagca   1320
 agttgtaact tattttggcc taaaaatgag gtttttttgg taaagaaaaa atatttgttc   1380
 ttatgtattg aagaagtgta cttttatata atgatttttt aaatgcccaa aggactagtt   1440
 tgaaagcttc ttttaaaaag aattcctcta atatgacttt atgtgagaag ggataataca   1500
 tgatcaaata aactcagttt tttatggtta ctgtaaaaag actgtgtaag gcagctcagc   1560
 accatgcttc tcgtaaaagc agcttcaatt atccactggg gttatctttt gacaacttgc   1620
 cattatctga tgttacacaa ttcaatagca agcaagtttg agacaatcgc agtttaaaag   1680
 catgaaccat ttaacaaaaa gtggaataat taaagataaa gcacttcttc ccaaagggaa   1740
 ttatcaccta gtgaaaaatt atgcatttca tctactcagt taccgactgc aagtctctcc   1800
 tcgctctagc tctcaagcct ttgggtgaat attcctgtga aatatatctt caacttgaaa   1860
 gttcatactc ccaatcaaaa actccctttt actgagtttg cagtactgta tttgcact     1918



      <210> 2361
      <211> 1020
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> misc_feature
      <222> (1)...(1020)
      <223> n = a,t,c or g


      <400> 2361
 aaaaatcacg gcagttcaca ttaaatttgg gcccccccaa aatttcttta gaggggcgcc     60
 cccccnntgt ttgnnnnnnn nnnnnnnnct ttccttgtgn gtattttggg atggtgacan    120
 nnnnnnnnnn nnnnnnnnnt cagaattagc cagccagact cagtttagat gatcccaatt    180
 ttgttggcaa catccaaagc atcataatca ggacccagaa gaatatgtgc cttcttctct    240
 ctatcagtcc taaccagggt gttgaccttg gccacatcaa tgtcacagag ctttttcaca    300
 gcctgtttga tctggtgctt gttggcttta acatccacaa tgaacacagg tgtgctgttg    360
 tcttctgtct tcttcatggg agactcagtg gtcagcagaa acttgatgat gacatagtgg    420
 ccaagcttgt ttctcctggg ggtcctaagc cagtttctgg aattctttac gtaaaaggca    480
 tggttacatg ttatgaaagc gcggaagaac ggctgttttc tttgtgtgac taaagccttg    540
 ggattcgtgg gcatatcacc agcgagggga tttctgcttt aaatattctc acagttttca    600
 aacattttca gcaccttagc aggaaactca gaggccactg aacctgctaa ggataaactt    660
 aatactggtt gatgccggag cccaggtgaa gtcctgtgct ccagagagcc tttaagaatg    720
 gcccaggaac tgctaacgaa cgtacagtac agtggtggtt caaaaagctt tgcaaaggag    780
 atgagagcct tgaagatgag gagcatagtg gctgaccatc ggaaatttac aacaaccaat    840
 tgagagcaat cttcaaagct gatcctctta caattacacg ggaagaagtt ttccctcatc    900
 cactatattc acctgacctc tcgccaacca gctaccactt cttccagcat cttgacaact    960
 ttttgcaggg aaaatgcttc cactaccagc aggatgcaga acatgctttc caagagtttg   1020



      <210> 2362
      <211> 1904
      <212> DNA
      <213> Homo sapiens


      <400> 2362
 cccaggcaag gaggtgctgg ggatggggaa tgttcacagg tgaacaacag cagtggtttt     60
 tcaacttctt tttcatcagc agaaactatt tacaaacagg gtttcatatg gacccccaat    120
 atagaagtca gataagggac tgaaccaggg actgggggcc cagggcccta gggctcagcc    180
 tcctcctcag cccacgaagc catgtgactg ctgggctggg gatcgaaggc agagcctggt    240
 tctgaagcct agagctggaa gctggctgag aaggtctggg aagcccagct ccctggattc    300
 ccctcgcccc ctcagtgctc cgtgcggtgc ggccggggcc agagaagccg gcaggttcgc    360
 tgtgttggga acaacggtga tgaagtgagc gagcaggagt gtgcgtcagg ccccccacag    420
 ccccccagca gagaggcctg tgacatgggg ccctgtacta ctgcctggtt ccacagcgac    480
 tggagctcca agtgctcagc cgagtgtggg acgggaatcc agcggcgctc tgtggtctgc    540
 cttgggagtg gggcagccct cgggccaggc cagggggaag caggagcagg aactgggcag    600
 agctgtccaa caggaagccg gccccctgac atgcgcgcct gcagcctggg gccctgtgag    660
 agaacttggc gctggtacac agggccctgg ggtgagtgct cctccgaatg tggctctggc    720
 acacagcgta gagacatcat ctgtgtatcc aaactgggga cggagttcaa cgtgacttct    780
 ccgagcaact gttctcacct ccccaggccc cctgccctgc agccctgtca agggcaggcc    840
 tgccaggacc gatggttttc cacgccctgg agcccatgtt ctcgctcctg ccaaggggga    900
 acgcagacac gggaggtcca gtgcctgagc accaaccaga ccctcagcac ccgatgccct    960
 cctcaactgc ggccctccag gaagcgcccc tgtaacagcc aaccctgcag ccagcgccct   1020
 gatgatcaat gcaaggacag ctctccacat tgccccctgg tggtacaggc ccggctctgc   1080
 gtctacccct actacacagc cacctgttgc cgctcttgcg cacatgtcct ggagcggtct   1140
 ccccaggatc cctcctgaaa ggggtccggg gcaccttcac ggttttctgt gccaccatcg   1200
 gtcacccatt gatcggccca ctctgaaccc cctggctctc cagcctgtcc cagtctcagc   1260
 agggatgtcc tccaggtgac agagggtggc aaggtgactg acacaaagtg actttcaggg   1320
 ctgtggtcag gcccatgtgg tggtgtgatg ggtgtgtgca catatgcctc aggtgtgctt   1380
 ttgggactgc atggatatgt gtgtgctcaa acgtgtatca cttttcaaaa agaggttaca   1440
 cagactgaga aggacaagac ctgtttcctt gagactttcc taggtggaaa ggaaagcaag   1500
 tctgcagttc cttgctaatc tgagctactt agagtgtggt ctccccacca actccagttt   1560
 tgtgccctaa gcctcatttc tcatgttcag acctcacatc ttctaagccg ccctgtgtct   1620
 ctgacccctt ctcatttgcc tagtatctct gcccctgcct ccctaattag ctagggctgg   1680
 ggtcagccac tgccaatcct gccttactca ggaaggcagg aggaaagaga ctgcctctcc   1740
 agagcaaggc ccagctgggc agagggtgaa aaagagaaat gtgagcatcc gctcccccac   1800
 caccccgccc agcccctagc cccactccct gcctcctgaa atggttccca cccagaacta   1860
 atttattttt tattaaagat ggtcatgaca aatgaaaaaa aaaa                    1904



      <210> 2363
      <211> 1871
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> misc_feature
      <222> (1)...(1871)
      <223> n = a,t,c or g


      <400> 2363
 atgtccagca aaggctccgt ggttctggcc tacagtggcg gcctggacac ctcgtgcatc     60
 ctcgtgtggc tgaaggaaca aggctatgac gtcattgcct atctggccaa cattggccag    120
 aaggaagact tcgaggaagc caggaagaag gcactgaagc ttggggccaa aaaggtgttc    180
 attgaggatg tcagcaggga gtttgtggag gagttcatct ggccggccat ccagtccagc    240
 gcactgtatg aggaccgcta cctcctgggc accttttttt gccaggccct gcatcgcccg    300
 caaacaagtg gaaattcgcc cagcgggagg gggccaagta tgtgtcccac ggcgccacag    360
 gaaaggggaa cgatcaggtc cggtttgagc tcagctgcta ctcactggcc cccccagata    420
 aaggtcattg ctccctggag gatgcctgaa ttctacaacc ggttcaaggg ccgcaatgac    480
 ctgatggagt acgcaaagct aacatgggat tcccatcccg gtcactccca agaacccgtg    540
 gagcatggat gagaacctca tgcacatcag ctacgaggct ggaatcctgg agaaccccaa    600
 gaaccaagcg cctccaggtc tctacacgaa gacccaggac ccagccaaag cccccaacac    660
 ccctgacatt ctcgagatcg agtttcaaaa aaggggtccc tgtggaaggt ggaccaacgt    720
 tcaaggatgg gcaccaccca ccagaccttt cttggagctc tttcatgtac ctgaacgaag    780
 tcgcgggcaa gcatggcgtt gggccgtatt tgacatcgtg ggagaaccgc tttcattggg    840
 aattgaagtc ccgaggtatc ttacggagac cccaggcagg gcaccatcct ttaccatgct    900
 catttagaca tcgaggcctt caccatgggc ggggataggg cgcaaatacc aaaccagggt    960
 ctgggctttg aatttgttga gcttggtgta taccggtttt ctggcacagc ccctgagtgt   1020
 gaattggtcg gcccttgcct tcgccaaagt ccccaggagc gagtggaagg gaaaagtgca   1080
 ggtgtcccgt ccctcaaagg gcccaggtgt acatccctcg gcccggaagt cccccactgt   1140
 tctctctaca atgaaggagc tggtgaagca tggaacgtgc cagggtgatt atgaagccca   1200
 actgattgcc acccgggttc atccaaacat caatttccct caaggctgaa gggaattatc   1260
 atcgtcttcc cagagcaaag gtcactgccc aaattagacc ccgtgtacaa tgaggagctt   1320
 ggggcctccc tcaatttgca agatcccccc aagtacaggc gcctaattgt tgtgataatt   1380
 tgtaattgtg acttgttctc cccggctggc agcgtaagtg gggctgccag gccccagctt   1440
 tgttccctgg tccccctgaa gcctgcaaac gttgtcatcg aagggaaggg tggggggcag   1500
 ctgcaggtgg ggagctataa aaatgacaat taaaagagac actagtcttt tatttctann   1560
 nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnttaa ttatgggttt cttaggccaa   1620
 cctttgtgtt ttcggaccta agtgctgccg aaggccgcca tttgccagac agcctgttaa   1680
 tccggctgtc gacccctctc cagcaaaaac taggaatcca gatgtgccgc ctgggtccga   1740
 tcctatccag catcctggga atctgtcacc aactgtggtc ctgtggcaaa tgtcaagaaa   1800
 ccaaataaaa ttcagggaat gccctttggg ggcatcaacg cacagccctt tctctggaca   1860
 tcacttttac t                                                        1871



      <210> 2364
      <211> 411
      <212> DNA
      <213> Homo sapiens


      <400> 2364
 gctggcgctg tctggggaaa tgaccttagt cctcttcatg ctccttgctg ggggctgggt     60
 tactcatgac aaacctgagc ccatgccgag ggcagccaca agcgggggca ccagaaaagg    120
 taaaacaaaa gctgccctca aggatctgat agccacgtgg aaggaggtgt gtgtctcctc    180
 gccagcaaca gaacaaagct ggatggagaa tgactttgat gagttgacag aagtaggctt    240
 cagaaggtcg gtaataacaa acttcttcaa gctaaaggag tatgttctaa cccatcacaa    300
 ggaagctaaa aaccttgaaa aaatgttaga cgaatggcta actagaatca acagtgtaga    360
 gaagacctta aatgacctga tggagctgaa aaacatggca tgagaacttc g             411



      <210> 2365
      <211> 4323
      <212> DNA
      <213> Homo sapiens


      <400> 2365
 ccaacttatt taaaacaaaa caattttgta ggtattatta tacccatttc acagatgatg     60
 ataaatgaga ccaatagaag ttaaataact tgccaaaggc cacacagctg gtgagtgatg    120
 gagaacgaat taaaactcaa gtgagcataa ttctaaaagc catcttctcg ttagtgtttc    180
 tcactatcca ggtctgcctt tgccttattt aactgaagtt aagccatcct tacctgtgat    240
 cacctagcct ctcagtttgg ggggatcatt acagcgggtt tttaactccc aatgttctgg    300
 tccagtttgc tttacatgtt cttatttata cattgtcaag gatgacctca ggacagtaca    360
 gcaaggacac agtggcactt cacattttgt tcccacgaaa tgactggggc ataatctcag    420
 atcatcttcc tttagaatgt ggaaacatca gcagaagaat attagtcttt atacaagtca    480
 aatccaaaat gacacatgtg aaaactaata gagctgactt tcagccatga tagctttggc    540
 acacctcaca tccctttgtt caacctctct tccctcaacg gagagctgca ttcctgggaa    600
 tttctgttgt gcacttttcc cacttgccct gctgtcattt aaaggtgaac attctagttt    660
 tgctaagaaa accctttcct tcatttggaa tgaacagcaa ttttattact tttgacctta    720
 aaatgagttt gctgccttca aatcttttca gcgccttcat cacgctctgc ttcggggcga    780
 tcttcttcct gccagactcc tccaagctgc tcagcggggt cctgttccac tccagccccg    840
 ccttgcagcc ggccgccgac cacaagcccg ggcccggggc gcgcgccgag gacgcggccg    900
 aggggcgagc ccggcgccgc gaggaggggg cacccgggga cccggaggcc gccctggagg    960
 acaacttggc caggatccgc gaaaaccacg agcgggctct cagggaagcc aaggagaccc   1020
 tgcagaagct gcccgaggag atccaaagag acatcctact ggagaagaag aaggtggccc   1080
 aggaccagct gcgtgacaag gcgccgttca gaggcctgcc cccggtggac ttcgtgcccc   1140
 caatcggggt ggagagccgg gagcccgccg acgccgccat ccgcgagaaa agggcaaaga   1200
 tcaaagagat gatgaaacat gcttggaata attataaagg ttatgcctgg ggattaaatg   1260
 aactcaaacc tatatcaaaa ggaggccatt caagcagttt gtttggtaac atcaaaggag   1320
 caactatagt agatgccctg gatacacttt ttattatgga aatgaaacat gaatttgaag   1380
 aagcaaaatc atgggttgaa gaaaatttag attttaatgt gaatgctgaa atttctgtct   1440
 ttgaagtaaa tatacgcttt gttggtggac tactctcagc ctactatctg tctggagaag   1500
 agatttttcg aaagaaagca gtggaacttg gggtaaaatt gctacctgca tttcatactc   1560
 cctctggaat accttgggca ttgctgaata tgaaaagtgg tattggaagg aactggccct   1620
 gggcctctgg aggcagcagt attctggcag aatttggaac cctgcatttg gagtttatgc   1680
 acttgagcca cttatcagga aaccccatct ttgctgaaaa ggtaatgaat attcgaacag   1740
 tactgaacaa actggaaaaa ccacaaggcc tttatcctaa ctatctgaat cccagtagtg   1800
 gacagtgggg tcaacatcat gtatcagttg gaggacttgg agacagcttc tatgagtatt   1860
 tgctgaaggc ctggttaatg tctgacaaga cagatctgga agctaagaag atgtattttg   1920
 atgctgttca ggctatcgag actcatttga tccgcaagtc tagcagcgga ctaacttata   1980
 tcgcagagtg gaaagggggc ctcctggagc acaagatggg ccacctgacc tgcttcgcgg   2040
 ggggcatgtt cgcactcggg gctgatgcag ctcccgaagg catggcccaa cactaccttg   2100
 aactcggggc tgaaattgcc cgtacttgtc atgaatcata taatcgaaca tttatgaaac   2160
 tgggaccaga agctttcaga tttgatggtg gtgttgaagc catcgctaca agacaaaatg   2220
 aaaaatacta catcttacgg ccagaagtta tggagactta catgtatatg tggagactga   2280
 ctcatgatcc aaagtacagg aaatgggcct gggaagccgt agaggccttg gaaaaccatt   2340
 gcagagtgaa tggaggctat tcaggcctaa gggatgttta ccttcttcat gagagttatg   2400
 atgatgtgca gcagagtttc ttcctggcag agacattgaa atatttgtac ctaatatttt   2460
 ctgacgacga tcttcttcca ctggagcatt ggatcttcaa tagcgaggca catcttctcc   2520
 ctatcctccc taaagataaa aaggaagttg aaatcagaga ggaataaaaa gacattttat   2580
 attttattct gctccattcc cttcactgta taccttaata attccttttc tggtaatcag   2640
 gcacatgatg aactttgatt agtaggtctg tgattaagtt cttaaattgt tttgcagtct   2700
 tttatgttta ttatcatagg tataggtgga cctaaattcc ttatcatatc ctttattaat   2760
 tcagccagtg tatccaccag ttttttgttt atgtttttaa gtaacctatt atctctggat   2820
 ttcatgaagg tgtaatatcg tttttgttaa actgaataga attgtatagc gatgacttct   2880
 taattataat ttgatttgac tgcaaaactt tttcctcctc taagaggaga tgatgtctgc   2940
 tttaagctgt aatgttttgc catgttgcaa aaagccataa taataagtat aaaaaagctt   3000
 tttcctttac aatttcatgt taatctggtt tgtctgtcca ccagagacag atcttctgtg   3060
 acagcctcct tatgcaggtc tatcattatt tgatagaatg tcttctaaaa tacttcactc   3120
 acattgtaat tcaaattaga aagtcattcc aaaaggatca tgtcatgttg acctcatttc   3180
 atcggaactg cagtatattt ttgttggtta attatattag tgttttctat tttgtaaatg   3240
 tgtcctttaa ttttacttta aatgccctgt gtcatttctg gattatatac tagttaattt   3300
 cttccattcc ctactacaca gagaggtgag ctttcaaatt ttgcagagct ctgctatcac   3360
 tgaattacat ttatctgaag aaaatagtac aacttaatgg attagctttt gggtttaact   3420
 gaatatatga agaaattggg tctgtctaaa gagagggtat ttcatatggc ttttagttca   3480
 cttgtttgta tttcatcttg atttttttct ttggaaaata aagcattcta tttggttcag   3540
 atttctcaga tttgaaaaag gctctatctc agatgtagta aattatttcc tttcagtttg   3600
 tgaaagcagg atttgactct gaaagaagct ttgccaattt tacttattcg tgatcaatca   3660
 aggaaaatct aataaatttt aggccaaata agaatatagc atatttagta tggttatagt   3720
 caacacagag atcacaactt agaagaaata taaagaaatg gccactcccc atcccccaca   3780
 gtcctggagt aaatcaaaat caatatatga ttcttttaaa cattaagttt gaaataggaa   3840
 tggttttctc aagaatagat ttggtgtgat accttgtgtt tgcttacatt ggcccactat   3900
 atatacatat atatttatgt agatatactt ccatgaaagg gctaatacga tgcatatact   3960
 gaagggcaag gactttgacc atgtgaattt tcagccgaga atggtcagaa agatcagtac   4020
 aaccccatgg attaggctga aacatatgaa attgctgcat ttgtagttta aaaactgtca   4080
 gcagtttcat atggttccac ctaatattat tgaagacaat tattttctta gctatcaata   4140
 ggcttaatag ttttagttat tttagctttt gaaagtgttt taaaagattt cctttatcgg   4200
 acaggaccat ctttatgacc tgctttctgt ttttcaatat catacattgg tgtatgtcaa   4260
 agaataaatt agtaaaatta gtaaatgaaa aagactcttc cgtacatcat tatttccatg   4320
 cta                                                                 4323



      <210> 2366
      <211> 3967
      <212> DNA
      <213> Homo sapiens


      <400> 2366
 cgccccccgc cgccgctgca caccggaccc agccgccgtg ccgcgggcca tggacctgcc     60
 caggggcctg gtggtggcct gggcgctcag cctgtggcca gggttcacgg acaccttcaa    120
 catggacacc aggaagcccc gggtcatccc tggctccagg accgccttct ttggctacac    180
 agtgcagcag cacgacatca gtggcaataa gtggctggtc gtgggcgccc cactggaaac    240
 caatggctac cagaagacgg gagacgtgta caagtgtcca gtgatccacg ggaactgcac    300
 caaactcaac ctgggaaggg tcaccctgtc caacgtgtcc gagcggaaag acaacatgcg    360
 cctcggcctt agtctcgcca ccaaccccaa ggacaacagc ttcctggcct gcagccccct    420
 ctggtctcat gagtgtggga gctcctacta caccacaggg atgtgttcaa gagtcaactc    480
 caacttcagg ttctccaaga ccgtggcccc agctctccaa aggtgccaga cctacatgga    540
 catcgtcatt gtcctggatg gctccaacag catctacccc tgggtggagg ttcagcactt    600
 cctcatcaac atcctgaaaa agttttacat tggcccaggg cagatccagg ttggagttgt    660
 gcagtatggc gaagatgtgg tgcatgagtt tcacctcaac gactacaggt ctgtaaaaga    720
 tgtggtggaa gctgccagcc acattgagca gagaggagga acagagaccc ggacggcatt    780
 tggcattgaa tttgcacgct cagaggcttt ccagaagggt ggaaggaaag gagccaagaa    840
 ggtgatgatt gtcatcacag atggggagtc ccacgacagc ccagacctgg agaaggtgat    900
 ccagcaaagc gaaagagaca acgtaacaag atatgcggtg gccgtcctgg gctactacaa    960
 ccgcaggggg atcaatccag aaacttttct aaatgaaatc aaatacatcg ccagtgaccc   1020
 tgatgacaag cacttcttca atgtcactga tgaggctgcc ttgaaggaca ttgtcgatgc   1080
 cctgggggac agaatcttca gcctggaagg caccaacaag aacgagacct cctttgggct   1140
 ggagatgtca cagacgggct tttcctcgca cgtggtggag gatggggttc tgctgggagc   1200
 cgtcggtgcc tatgactgga atggagctgt gctaaaggag acgagtgccg ggaaggtcat   1260
 tcctctccgc gagtcctacc tgaaagagtt ccccgaggag ctcaagaacc atggtgcata   1320
 cctggggtac acagtcacat cggtcgtgtc ctccaggcag gggcgagtgt acgtggccgg   1380
 agccccccgg ttcaaccaca cgggcaaggt catcctgttc accatgcaca acaaccggag   1440
 cctcaccatc caccaggcta tgcggggcca gcagataggc tcttactttg ggagtgaaat   1500
 cacctcggtg gacatcgacg gcgacggcgt gactgatgtc ctgctggtgg gcgcacccat   1560
 gtacttcaac gagggccgtg agcgaggcaa ggtgtacgtc tatgagctga gacagaaccg   1620
 gtttgtttat aacggaacgc taaaggattc acacagttac cagaatgccc gatttgggtc   1680
 ctccattgcc tcagttcgag acctcaacca ggattcctac aatgacgtgg tggtgggagc   1740
 ccccctggag gacaaccacg caggagccat ctacatcttc cacggcttcc gaggcagcat   1800
 cctgaagaca cctaagcaga gaatcacagc ctcagagctg gctaccggcc tccagtattt   1860
 tggctgcagc atccacgggc aattggacct caatgaggat gggctcatcg acctggcagt   1920
 gggagccctt ggcaacgctg tgattctgtg gtcccgccca gtggttcaga tcaatgccag   1980
 cctccacttt gagccatcca agatcaacat cttccacaga gactgcaagc gcagtggcag   2040
 ggatgccacc tgcctggccg ccttcctctg cttcacgccc atcttcctgg caccccattt   2100
 ccaaacaaca actgttggca tcagatacaa cgccaccatg gatgagaggc ggtatacacc   2160
 gagggcccac ctggacgagg gcggggaccg attcaccaac agagccgtac tgctctcctc   2220
 cggccaggag ctctgtgagc ggatcaactt ccatgtcctg gacactgctg actacgtgaa   2280
 gccagtgacc ttctcagtcg agtattccct ggaggaccct gaccatggcc ccatgctgga   2340
 cgacggctgg cccaccactc tcagagtctc ggtgcccttc tggaacggct gcaatgagga   2400
 tgagcactgt gtccctgacc ttgtgttgga tgcccggagt gacctgccca cggccatgga   2460
 gtactgccag agggtgctga ggaagcctgc gcaggactgc tccgcataca cgctgtcctt   2520
 cgacaccaca gtcttcatca tagagagcac acgccagcga gtggcggtgg aggccacact   2580
 ggagaacagg ggcgagaacg cctacagcac ggtcctaaat atctcgcagt cagcaaacct   2640
 gcagtttgcc agcttgatcc agaaggagga ctcagacggt agcattgagt gtgtgaacga   2700
 ggagaggagg ctccagaagc aagtctgcaa cgtcagctat cccttcttcc gggccaaggc   2760
 caaggtggct ttccgtcttg attttgagtt cagcaaatcc atcttcctac accacctgga   2820
 gatcgagctc gctgcaggca gtgacagtaa tgagcgggac agcaccaagg aagacaacgt   2880
 ggccccctta cgcttccacc tcaaatacga ggttgacgtc ctcttcacca ggagcagcag   2940
 cctgagccac tatgaggtca agcccaacag ctcgctggag agatacgatg gtatcgggcc   3000
 tcccttcagc tgcatcttca ggatccagaa cttgggcttg ttccccatcc acgggatgat   3060
 gatgaagatc accattccca tcgccaccag gagcggcaac cgcctactga agctgaggga   3120
 cttcctcacg gacgaggcga acacgtcctg taacatctgg ggcaatagca ctgagtaccg   3180
 gcccacccca gtggaggaag acttgcgtcg tgctccacag ctgaatcaca gcaactctga   3240
 tgtcgtctcc atcaactgca atatacggct ggtccccaac caggaaatca atttccatct   3300
 actggggaac ctgtggttga ggtccctaaa agcactcaag tacaaatcca tgaaaatcat   3360
 ggtcaacgca gccttgcaga ggcagttcca cagccccttc atcttccgtg aggaggatcc   3420
 cagccgccag atcgtgtttg agatctccaa gcaagaggac tggcaggtcc ccatctggat   3480
 cattgtaggc agcaccctgg ggggcctcct actgctggcc ctgctggtcc tggcactgtg   3540
 gaagctcggc ttctttagaa gtgccaggcg caggagggag cctggtctgg accccacccc   3600
 caaagtgctg gagtgaggct ccagaggaga ctttgagttg atgggggcca ggacaccagt   3660
 ccaggtagtg ttgagaccca ggcctgtggc cccaccgagc tggagcggag aggaagccag   3720
 ctggctttgc acttgacctc atctcccgag caatggcgcc tgctccctcc agaatggaac   3780
 tcaagctggt tttaagtgga actgccctac tgggagactg ggacaccttt aacacagacc   3840
 cctagggatt taaagggaca cccctacaca cacccaggcc cacgccaagg cctccctcag   3900
 gctctgtgga gggcatttgc tgccccagct actaaggtgc taggaattcg taatcatccc   3960
 cattctc                                                             3967



      <210> 2367
      <211> 2693
      <212> DNA
      <213> Homo sapiens


      <400> 2367
 cagagcaggg cgagagccga tcagcggatc accgagtctc gccaggtggt ggagctggca     60
 gtgaaggagc acaaggctga gattctcgct ctgcagcagg ctctcaaaga gcagaagctg    120
 aaggccgaga gcctctctga caagctcaat gacctggaga agaagcatgc tatgcttgaa    180
 atgaatgccc gaagcttaca gcagaagctg gagactgaac gagagctcaa acagaggctt    240
 ctggaagagc aagccaaatt acagcagcag atggacctgc agaaaaatca cattttccgt    300
 ctgactcaag gactgcaaga agctctagat cgggctgatc tactgaagac agaaagaagt    360
 gacttggagt atcagctgga aaacattcag gttctctatt ctcatgaaaa ggtgaaaatg    420
 gaaggcacta tttctcaaca aaccaaactc attgattttc tgcaagccaa aatggaccaa    480
 cctgctaaaa agaaaaaggt tcctctgcag tacaatgagc tgaagctggc cctggagaag    540
 gagaaagctc gctgtgcaga gctagaggaa gcccttcaga agacccgcat cgagctccgg    600
 tccgcccggg aggaagctgc ccaccgcaaa gcaacggacc acccacaccc atccacgcca    660
 gccaccgcga ggcagcagat cgccatgtct gccatcgtgc ggtcgccaga gcaccagccc    720
 agtgccatga gcctgctggc cccgccatcc agccgcagaa aggagtcttc aactccagag    780
 gaatttagtc ggcgtcttaa ggaacgcatg caccacaata ttcctcaccg attcaacgta    840
 ggactgaaca tgcgagccac aaagtgtgct gtgtgtctgg ataccgtgca ctttggacgc    900
 caggcatcca aatgtctcga atgtcaggtg atgtgtcacc ccaagtgctc cacgtgcttg    960
 ccagccacct gcggcttgcc tgctgaatat gtcacacact tcaccgaggc cttctgccgt   1020
 gacaaaatga actccccagg tctccagacc aaggagccca gcagcagctt gcacctggaa   1080
 gggtggatga aggtgcccag gaataacaaa cgaggacagc aaggctggga caggaagtac   1140
 attgtcctgg agggatcaaa agtcctcatt tatgacaatg aagccagaga agctggacag   1200
 aggccggtgg aagaatttga gctgtgcctt cccgacgggg atgtatctat tcatggtgcc   1260
 gttggtgctt ccgaactcgc aaatacagcc aaagcagatg tcccatacat actgaagatg   1320
 gaatctcacc cgcacaccac ctgctggccc gggagaaccc tctacttgct agctcccagc   1380
 ttccctgaca aacagcgctg ggtcaccgcc ttagaatcag ttgtcgcagg tgggagagtt   1440
 tctagggaaa aagcagaagc tgatgctaaa ctgcttggaa actccctgct gaaactggaa   1500
 ggtgatgacc gtctagacat gaactgcacg ctgcccttca gtgaccaggt ggtgttggtg   1560
 ggcaccgagg aagggctcta cgccctgaat gtcttgaaaa actccctaac ccatgtccca   1620
 ggaattggag cagtcttcca aatttatatt atcaaggacc tggagaagct actcatgata   1680
 gcaggagaag agcgggcact gtgtcttgtg gacgtgaaga aagtgaaaca gtccctggcc   1740
 cagtcccacc tgcctgccca gcccgacatc tcacccaaca tttttgaagc tgtcaagggc   1800
 tgccacttgt ttggggcagg caagattgag aacgggctct gcatctgtgc agccatgccc   1860
 agcaaagtcg tcattctccg ctacaacgaa aacctcagca aatactgcat ccggaaagag   1920
 atagagacct cagagccctg cagctgtatc cacttcacca attacagtat cctcattgga   1980
 accaataaat tctacgaaat cgacatgaag cagtacacgc tcgaggaatt cctggataag   2040
 aatgaccatt ccttggcacc tgctgtgttt gccgcctctt ccaacagctt ccctgtctca   2100
 atcgtgcagg tgaacagcgc agggcagcga gaggagtact tgctgtgttt ccacgaattt   2160
 ggagtgttcg tggattctta cggaagacgt agccgcacag acgatctcaa gtggagtcgc   2220
 ttacctttgg cctttgccta cagagaaccc tatctgtttg tgacccactt caactcactc   2280
 gaagtaattg agatccaggc acgctcctca gcagggaccc ctgcccgagc gtacctggac   2340
 atcccgaacc cgcgctacct gggccctgcc atttcctcag gagcgattta cttggcgtcc   2400
 tcataccagg ataaattaag ggtcatttgc tgcaagggaa acctcgtgaa ggagtccggc   2460
 actgaacacc accggggccc gtccacctcc cgcaggtaac cagcttctcc tcttcctcag   2520
 taccaggggc aacgtgcttt tctgcaaggc agaaggaagt gatactaaac cagtagaatg   2580
 tttcccaatc ttcactttgt tcttaagctc aaaccattca tttgtttgcg atctgcggca   2640
 ctgaaataac acagaccatt atgagcatca ggagaattag aaaataccac ctt          2693



      <210> 2368
      <211> 1575
      <212> DNA
      <213> Homo sapiens


      <400> 2368
 tttcgtcccg cgcccggact ttgccatcgg cggggcagtc gcgggatgcg cccgggagcc     60
 acagcctgag gccctcaggt ctctgcaggt gtcgtggagg aacctagcac ctgccatcct    120
 cttccccaat ttgccacttc cagcagcttt agcccatgag gaggatgtga ccgggactga    180
 gtcaggagcc ctctggaagc atggagactg tggtgattgt tgccataggt gtgctggcca    240
 ccatctttct ggcttcgttt gcagccttgg tgctggtttg caggcagcgc tactgccggc    300
 cgcgagacct gctgcagcgc tatgattcta agcccattgt ggacctcatt ggtgccatgg    360
 agacccagtc tgagccctct gagttagaac tggacgatgt cgttatcacc aacccccaca    420
 ttgaggccat tctggagaat gaagactgga tcgaagatgc ctcgggtctc atgtcccact    480
 gcattgccat cttgaagatt tgtcacactc tgacagagaa gcttgttgcc atgacaatgg    540
 gctctggggc caagatgaag acttcagcca gtgtcagcga catcattgtg gtggccaagc    600
 ggatcagccc cagggtggat gatgttgtga agtcgatgta ccctccgttg gaccccaaac    660
 tcctggacgc acggacgact gccctgctcc tgtctgtcag tcacctggtg ctggtgacaa    720
 ggaatgcctg ccatctgacg ggaggcctgg actggattga ccagtctctg tcggctgctg    780
 aggagcattt ggaagtcctt cgagaagcag ccctagcttc tgagccagat aaaggcctcc    840
 caggccctga aggcttcctg caggagcagt ctgcaattta gtgcctacag gccagcagct    900
 agccatgaag gcccctgccg ccatccctgg atggctcagc ttagccttct actttttcct    960
 atagagttag ttgttctcca cggctggaga gttcagctgt gtgtgcatag taaagcagga   1020
 gatccccgtc agtttatgcc tcttttgcag ttgcaaactg tggctggtga gtggcagtct   1080
 aatactacag ttaggggaga tgccattcac tctctgcaag aggagtattg aaaactggtg   1140
 gactgtcagc tttatttagc tcacctagtg ttttcaagaa aattgagcca ccgtctaaga   1200
 aatcaagagg tttcacatta aaattagaat ttctggcctc tctcgatcgg tcagaatgtg   1260
 tggcaattct gatctgcatt ttcagaagag gacaatcaat tgaaactaag taggggtttc   1320
 ttcttttggc aagacttgta ctctctcacc tggcctgttt catttatttg tattatctgc   1380
 ctggtccctg aggcgtctgg gtctctcctc tcccttgcag gtttgggttt gaagctgagg   1440
 aactacaaag ttgatgattt cttttttatc tttatgcctg caattttacc tagctaccac   1500
 taggtggata gtaaatttat acttatgttt caaaaaaaaa tcatcaactt tgtagttcct   1560
 cagcttcagt cgacg                                                    1575



      <210> 2369
      <211> 3559
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> misc_feature
      <222> (1)...(3559)
      <223> n = a,t,c or g


      <400> 2369
 tttcgtcgcc tagggagaaa acgtctgact ccagccaccg gccttcaagg cacggctttt     60
 tattccttcg gctggtcggc ctctcgccct tcagctacct gtgcgtccct ccgtcccgtc    120
 ccgtcccggg gtcaccccgg agcctgtccg ctatgcggct cctgcctcta gccccaggtc    180
 ggctccggcg gggcagcccc cgccacctgc cctcctgcag cccagcgctg ctactgctgg    240
 tgctgggcgg ctgcctgggg gtcttcgggg tggctgcggg aacccggagg cccaacgtgg    300
 tgctgctcct cacggacgac caggacgaag tgctcggcgg catgacacca ctaaagaaaa    360
 ccaaagctct catcggagag atggggatga ctttttccag tgcttatgtg ccaagtgctc    420
 tctgctgccc cagcagagcc agtatcctga caggaaagta cccacataat catcacgttg    480
 tgaacaacac tctggagggg aactgcagta gtaagtcctg gcagaagatc caagaaccaa    540
 atactttccc agcaattctc agatcaatgt gtggttatca gacctttttt tgcagggaaa    600
 tatttaaatg agtacggagc cccagatgca ggtggactag aacacgttcc tctgggttgg    660
 agttactggt atgccttgga aaagaattct aagtattata attacaccct gtctatcaat    720
 gggaaggcac ggaagcatgg tgaaaactat agtgtggact acctgacaga tgttttggct    780
 aatgtctcct tggactttct ggactacaag tccaactttg agcccttctt catgatgacc    840
 gccactccaa gcgcctcatt cgccttggac agctgcacct cagtaccaga aggctttcca    900
 gaatgtcttt gcaccaagaa acaagaactt caacatccat ggaacgaaca agcactggtt    960
 aattaggcaa gccaagactc caatgactaa ttcttcaata cagtttttag ataatgcatt   1020
 taggaaaagg tggcaaactc tcctctcagt tgatgacctt gtggagaaac tggtcaagag   1080
 gctggagttc actggggagc tcaacaacac ttacatcttc tatacctcag acaatggcta   1140
 tcacacagga cagttttcct tgccaataga caagagacag ctgtatgagt ttgatatcaa   1200
 agttccactg ttggttcgag gacctgggat caaaccaaat cagacaagca agatgctggt   1260
 tgccaacatt gacttgggtc ctactatttt ggacattgct ggctacgacc taaataagac   1320
 acagatggat gggatgtcct tattgcccat tttgagaggt gccagtaact tgacctggcg   1380
 atcagatgtc ctggtggaat accaaggaga aggccgtaac gtcactgacc caacatgccc   1440
 ttccctgagt cctggcgtat ctcaatgctt cccagactgt gtatgtgaag atgcttataa   1500
 caatacctat gcctgtgtga ggacaatgtc agcattgtgg aatttgcagt attgcgagtt   1560
 tgatgaccag gaggtgtttg tagaagtcta taatctgact gcagacccag accagatcac   1620
 taacattgct aaaaccatag acccagagct tttaggaaag atgaactatc ggttaatgat   1680
 gttacagtcc tgttctgggc caacctgtcg cactccaggg gtttttgacc ccggatacag   1740
 gtttgacccc cgtctcatgt tcagcaatcg cggcagtgtc aggactcgaa gattttccaa   1800
 acatcttctg tagcgacctc acacagcctc tgcagatgga tccctgcacg ccctctttct   1860
 gatgaagtga ttgtagtagg tgtctgtagc ctagtcttca agaccacacc ctggaagagt   1920
 ttctgggctg gctttaagtc ctgtttgaaa aagcaaccca gtcagctgac ttcctcgtgc   1980
 aatgtgttaa actgtgaact ctgcccatgt gtcaggagtg gctgtctctg gtctcttcct   2040
 ttagctgaca aggacactcc tgaggtcttt gttctcactg tattcttttt atcctggggc   2100
 cacagttctt gattattcct cttgtggtta aagactgaat ttgtaaaccc attcagataa   2160
 atggcagtac tttaggacac acacaaacac acagatacac cttttgatat gtaagcttga   2220
 cctaaagtca aaggacctgt gtagcatttc agattgagca cttcactatc aaaaatacta   2280
 acatcacatg gcttgaagag taaccatcag agctgaatca tccaagtaag aacaagtacc   2340
 attgttgatt gataagtaga gatacatttt ttatgatgtt catcacagtg tggtaaggtt   2400
 gcaaattcaa aacatgtcac ccaagctctg ttcatgtttt tgtgaattct aggctggtgc   2460
 tgcactgaaa tagagcagta agcttgtgat aaaggccaat tccaggtagc tcttgaaggt   2520
 gatagccatc tactttccag tggctgccaa ccacagggag tgccagttaa cactggaagg   2580
 attaaggcaa ggtcccttct cttgagactc ccctctgaga tctgaaaaat gaagtggctt   2640
 aggaacatca gcagtgaaga actgccaaga gttggtgaag gttgtctctt ccgagggcct   2700
 tctgaagaca gggctcttga acagacaagt ggaagggctg taccagggat aaaggaaaga   2760
 agtgcctgtc cagcagggag cttgaattta agttccatgt atgaagtcat tggctctatc   2820
 tgcatttttc tgtcattctc ttcatttgtt ttaaggtgga aaattttctt acagttgatg   2880
 caaagtatca actactttac cctaccttct ccccttttag atgggttctt cctgagtttt   2940
 ggagtcttgt atgattatca gtattcccct gtcaaaatca aatctattca ggtttcttca   3000
 ctgttgagaa cacctaaatg tttttatttt tgagaagtgg ggacagagtc tcactatgtc   3060
 acccaggctg gagtgcaatg gcatgatctc agctcactgc aaccttcgcc tcctgggttc   3120
 aagcgattct cctgcctccg cctcctgagt agctgggatt ataggcacac accaccacgc   3180
 ccagctaatt ttttgtattt ttagtagaga cagagtttca ccatgttggc caggctggtc   3240
 ttgaactcct gaccttgtga tccacccacc tcggcctccc agagtgctgg gattacaggc   3300
 atgagccacc acgcttggct aagaacacct aaatttttat gtttcttggc tcaaaaacca   3360
 gttccatttc taatgttgtc ctcacaagaa ggctaattgg tggtgagaca gcaggggagg   3420
 aggaagagct gtggtttgta acttgttcaa ctcaggcaat aagcgatttt agctttattt   3480
 aaagtcttct gtccagcttt aagcactttg taagacatgg ctgaaagtag cttttctttt   3540
 caganttgca gatagtcat                                                3559



      <210> 2370
      <211> 474
      <212> DNA
      <213> Homo sapiens


      <400> 2370
 accggactgg cctggggggg acgtgggcgc ggggcggcgt gcggcacgtg cagggctgaa     60
 gcggcggcgc ggtggggact gcacgtagcc cggcgctcgg catggctctc ctggtgctcg    120
 gtctggtgag ctgtaccttc tttctggcag tgaatggtct gtattcctct agtgatgatg    180
 tgatcgaatt aactccatca aatttcaacc gagaagttat tcagagtgag agccacaaca    240
 gaggcttcag accattttct tttcttggga gccagtggat ttttccagca gtgaagggac    300
 attctctaca ctcagatgac tctaccagtg gcccttttaa ccaagaagta gtacttgatt    360
 ggtcatttga aaacactgca acagtgaact tttgcatctc aagaaaacat tgaaaaattc    420
 tatgaattgt tgtagccggt gaattgagtc gtattctgtc acataatatt ttga          474



      <210> 2371
      <211> 4242
      <212> DNA
      <213> Homo sapiens


      <400> 2371
 agcgccgccg gccgggaggc gaaggatgca ggcggctccg cgcgccggct gcggggcagc     60
 gctcctgctg tggattgtca gcagctgcct ctgcagagcc tggacggctc cctccacgtc    120
 ccaaaaatgt gatgagccac ttgtctctgg actcccccat gtggctttca gcagctcctc    180
 ctccatctct ggtagctatt ctcccggcta tgccaagata aacaagagag gaggtgctgg    240
 gggatggtct ccatcagaca gcgaccatta tcaatggctt caggttgact ttggcaatcg    300
 gaagcagatc agtgccattg caacccaagg aaggtatagc agctcagatt gggtgaccca    360
 ataccggatg ctctacagcg acacagggag aaactggaaa ccctatcatc aagatgggaa    420
 tatctgggca tttcccggaa acattaactc tgacggtgtg gtccggcacg aattacagca    480
 tccgattatt gcccgctatg tgcgcatagt gcctctggat tggaatggag aaggtcgcat    540
 tggactcaga attgaagttt atggctgttc ttactgggct gatgttatca actttgatgg    600
 ccatgttgta ttaccatata gattcagaaa caagaagatg aaaacactga aagatgtcat    660
 tgccttgaac tttaagacgt ctgaaagtga aggagtaatc ctgcacggag aaggacagca    720
 aggagattac attaccttgg aactgaaaaa agccaagctg gtcctcagtt taaacttagg    780
 aagcaaccag cttggcccca tatatggcca cacatcagtg atgacaggaa gtttgctgga    840
 tgaccaccac tggcattctg tggtcattga gcgccagggg cggagcatta acctcactct    900
 ggacaggagc atgcagcact tccgtaccaa tggagagttt gactacctgg acttggacta    960
 tgagataacc tttggaggca tccctttctc tggcaagccc agctccagca gtagaaagaa   1020
 tttcaaaggc tgcatggaaa gcatcaacta caatggcgtc aacattactg atcttgccag   1080
 aaggaagaaa ttagagccct caaatgtggg aaatttgagc ttttcttgtg tggaacccta   1140
 tacggtgcct gtctttttca acgctacaag ttacctggag gtgcccggac ggcttaacca   1200
 ggacctgttc tcagtcagtt tccagtttag gacatggaac cccaatggtc tcctggtctt   1260
 cagtcacttt gcggataatt tgggcaatgt ggagattgac ctcactgaaa gcaaagtggg   1320
 tgttcacatc aacatcacac agaccaagat gagccaaatc gatatttcct caggttctgg   1380
 gttgaatgat ggacagtggc acgaggttcg cttcctagcc aaggaaaatt ttgctattct   1440
 caccatcgat ggagatgaag catcagcagt tcgaactaat agtccccttc aagttaaaac   1500
 tggcgagaag tacttttttg gaggttttct gaaccagatg aataactcaa gtcactctgt   1560
 ccttcagcct tcattccaag gatgcatgca gctcattcaa gtggacgatc aacttgtaaa   1620
 tttatacgaa gtggcacaaa ggaagccggg aagtttcgcg aatgtcagca ttgacatgtg   1680
 tgcaatcata gacagatgtg tgcccaatca ctgtgagcat ggtggaaagt gctcgcaaac   1740
 atgggacagc ttcaaatgca cttgtgatga gacaggatac agtggggcca cctgccacaa   1800
 ctctatctac gagccttcct gtgaagccta caaacaccta ggacagacat caaattatta   1860
 ctggatagat cctgatggca gcggacctct ggggcctctg aaagtttact gcaacatgac   1920
 agaggacaaa gtgtggacca tagtgtctca tgacttgcag atgcagacgc ctgtggtcgg   1980
 ctacaaccca gaaaaatact cagtgacaca gctcgtttac agcgcctcca tggaccagat   2040
 aagtgccatc actgacagtg ccgagtactg cgagcagtat gtctcctatt tctgcaagat   2100
 gtcaagattg ttgaacaccc cagatggaag cccttacact tggtgggttg gcaaagccaa   2160
 cgagaagcac tactactggg gaggctctgg gcctggaatc cagaaatgtg cctgcggcat   2220
 cgaacgcaac tgcacagatc ccaagtacta ctgtaactgc gacgcggact acaagcaatg   2280
 gaggaaggat gctggtttct tatcatacaa agatcacctg ccagtgagcc aagtggtggt   2340
 tggagatact gaccgtcaag gctcagaagc caaattgagc gtaggtcctc tgcgctgcca   2400
 aggagacagg aattattgga atgccgcctc tttcccaaac ccatcctcct acctgcactt   2460
 ctctactttc caaggggaaa ctagcgctga catttctttc tacttcaaaa cattaacccc   2520
 ctggggagtg tttcttgaaa atatgggaaa ggaagatttc atcaagctgg agctgaagtc   2580
 tgccacagaa gtgtcctttt catttgatgt gggaaatggg ccagtagaga ttgtagtgag   2640
 gtcaccaacc cctctcaacg atgaccagtg gcaccgggtc actgcagaga ggaatgtcaa   2700
 gcaggccagc ctacaggtgg accggctacc gcagcagatc cgcaaggccc caacagaagg   2760
 ccacacccgc ctggagctct acagccagtt atttgtgggt ggtgctgggg gccagcaggg   2820
 cttcctgggc tgcatccgct ccttgaggat gaatggggtg acacttgacc tggaggaaag   2880
 agcaaaggtc acatctgggt tcatatccgg atgctcgggc cattgcacca gctatggaac   2940
 aaactgtgaa aatggaggca aatgcctaga gagataccac ggttactcct gcgattgctc   3000
 taatactgca tatgatggaa cattttgcaa caaagatgtt ggtgcatttt ttgaagaagg   3060
 gatgtggcta cgatataact ttcaggcacc agcaacaaat gccagagact ccagcagcag   3120
 agtagacaac gctcccgacc agcagaactc ccacccggac ctggcacagg aggagatccg   3180
 cttcagcttc agcaccacca aggcgccctg cattctcctc tacatcagct ccttcaccac   3240
 agacttcttg gcagtcctcg tcaaacccac tggaagctta cagattcgat acaacctggg   3300
 tggcacccga gagccataca atattgacgt agaccacagg aacatggcca atggacagcc   3360
 ccacagtgtc aacatcaccc gccacgagaa gaccatcttt ctcaagctcg atcattatcc   3420
 ttctgtgagt taccatctgc caagttcatc cgacaccctc ttcaattctc ccaagtcgct   3480
 ctttctggga aaagttatag aaacagggaa aattgaccaa gagattcaca aatacaacac   3540
 cccaggattc actggttgcc tctccagagt ccagttcaac cagatcgccc ctctcaaggc   3600
 cgccttgagg cagacaaacg cctcggctca cgtccacatc cagggcgagc tggtggagtc   3660
 caactgcggg gcctcgccgc tgaccctctc ccccatgtcg tccgccaccg acccctggca   3720
 cctggatcac ctggattcag ccagtgcgga ttttccatat aatccaggac aaggccaagc   3780
 tataagaaat ggagtcaaca gaaactcggc tatcattgga ggcgtcattg cctgtggtga   3840
 ttttcacccc atccctgtgc acccccggtc cttccctgat cccggtaaca tgtttccccc   3900
 cacaagggca ccctacccat acccaacgaa gcaaaggggg ccggaagtcg gcagaagaag   3960
 cccggacgcc gcccatccat gaacaacgac cccccaactt cacagagacc cattgatgaa   4020
 agcaaaaagg aatggcctca tttgaggggt ggctacttgg ctatgggata gggaggaggg   4080
 aattactagg gaggagagaa agggacaaaa gcacccttgc ttcatactct tgagcacatc   4140
 cttaaaatat cagcacaagt tgggggaggc aggcaatgga atataatgga atattcttga   4200
 gactgatcac aaaaaaaaaa aaccttttta atatttcttt aa                      4242



      <210> 2372
      <211> 2193
      <212> DNA
      <213> Homo sapiens


      <400> 2372
 tttttttttt ttaactggca aaggcatatt tttatttaaa taaatcaatc tcacaactgt     60
 aattcgaact tgaaattagc aaagtttctt tcacttctta cacataaaaa ccttaaattt    120
 taactgtaat aaagtgtgaa tcctttaata acctgggttt ttaaaagggt gccacccaat    180
 gggggtaatg gaaaaggggg atgttaatgt actaggcttc cctggaaaat attttaaaca    240
 tttttcatac aatactaggg aaaacttccc cttcttccac gtttaggctt aatagaacaa    300
 atcacatgga aagtttcata gtgggttctt ttatttataa aataatcaca ttcaagtctt    360
 accagagagt agcaaagtct tcaattcctt tcctttcctt tgaagaaata atgtagagca    420
 atcactcata aatccctcta attataaata aaatccaaga tattatttga caatgagatg    480
 ctttatttaa acttgataca tttactatat aagaattctg tgaaaaaatg gggtatgaaa    540
 ttattttgga tctgaatctt tgcattataa aatctaaccc aaaactatgt catttcactg    600
 tattctgtga ctattagcag atggatgacc aaaggcaact acttcctttc ctggcaaaac    660
 aagacaagtt tcagctgact tccccatggt gttacaagtt ctcctagtga agtaaaaagt    720
 cccaacccct ctttctatgc atgtcatctc caggaaggta agctttggga agcacctgcg    780
 ccagccctat atctgtgctt ggcatgaggt tcacacaggt tcggccttga gatggggatg    840
 ttcctctcaa ccaaacaact ctacttgaat tattccgaga ctccttggag gggtgaaact    900
 tcaggcctgg gtgtctctgc agtgagatgt ctgtggttgg taaacagttc tgtagagtct    960
 tgttctactg atctttcttc taggtctgac tctgggattg tagtacaacc acctggcatg   1020
 accatggtct ggtgggggct gctgcatcgg tacttaggca gagacggcca cctttggata   1080
 atctatcgca gagcaaggtg atatgtttct tcagttgggc tcgtgtcatt ggggtatgtc   1140
 agcctgcctg gtgggttcaa agcctgctgc ttagcactct tacgacagca agtctttcac   1200
 atggtggaaa atggcggcat ccaccgtttc ttcccagccc aattcttgag tgtcttcttg   1260
 tagcggcaga aatgccgctt ccagaatagc aacctggtca gcactaagct tctgccacag   1320
 cgcgatcagc agaatcacca aatgggtggc actcttcagc ctggtgaatg actggaacag   1380
 attgcccttg gttttccctc ccactgcatc ctgctagagc aattacctgc cttgtaggtt   1440
 cccatcctaa caaggtgtcc caggtgttga agaggggcag gagttttatc tttgaatctt   1500
 gctagtagcc ggcgttgaat ggcccgaaat tgtacagctc tctcagataa gagttcttct   1560
 aatttttcac catttatccg tagctcaaaa tggatggatc caatcaactc caaaatattc   1620
 cttgaaaggg gtaatagatc cccgaaaaag aacatgcaaa atctttgact ccctgttttt   1680
 caaaatattc ttgaaggcga agaataagct cattggttaa tgaagcccaa agatccttca   1740
 aattgttcca ctcctggaat gcgaatatcc gttgaagaag ttttggaagc aagaacagta   1800
 attccgagca cctccctaag aagtgaaaac ccattacatt cacctgatca tcatctgact   1860
 gactggcaaa acctgggaag agactaagaa gactgactgg agatttgttg gtatcaatag   1920
 taattttgtg gcttgcagtt tttgaaggct gacctggtag gcaaattaac tttaggggaa   1980
 gtctaaattt acattggata actcgcggaa tgccatcagg atttcgattc ataaattcaa   2040
 aggtgaactg atcacaagtc aattctaatg gtggttgcac gtagactgat aatttggctt   2100
 tttgcaatat cactctgttc tgcagtgtga ccttcaccgt gacagaaggg acaaggtcag   2160
 ttcccacctc aacatcggtc gcttgagaaa ctg                                2193



      <210> 2373
      <211> 634
      <212> DNA
      <213> Homo sapiens


      <400> 2373
 accgccccgg aatttccggg tcgacgattt cgtggcgaga gagtggcagc gggggctgat     60
 ggaagtgcag tggtgggctg gagagggcac cctagtgagt tggcttttct ctccttcggt    120
 gcctttggtt gggctcgagg cccggggtcg gaggccatca ggacaagagt gtgggacttg    180
 gaagggcagc cacctggagc ttggaagggg ctgtatccag catgctccaa ggccacagct    240
 ctgtgttcca ggccttgctg gggaccttct tcacctgggg gatgacagca gctggggcag    300
 ctctcgtgtt cgtattctct agtggacaga ggcggatctt agatggaagt cttggctttg    360
 ctgcaggggt aagtagcatg tagtaggaga aatggaaatt gaggcatact gattctgaca    420
 tgtgtctgcc aagggctgtc ttcagtccct ccccttgcga cctagatgca tctctgtgtt    480
 cctcaggcac taacacctcc ctcttatcac ctgccatatt tatttcccag cttatcaaat    540
 gcccatttct ctttagacag caatcgaagt ttatttgaca gctgcctcag gactagggaa    600
 ataagatctt atttggtaag ggcctagcac aggc                                634



      <210> 2374
      <211> 1998
      <212> DNA
      <213> Homo sapiens


      <400> 2374
 aaatactcct tacataattt aggagaacaa aacgtaactt actagattga tggaacatat     60
 ttctattatc cccgattaca gacaagcctg gaaagtggaa cataaattat cggatattct    120
 actgttgact atttgtgccg ttatttctgg tgcagaaggc tgggaagata tagaggattt    180
 tggggaaaca catcccgatt ttttgaagca atatggtgat tttgaaaatg gtattcctgt    240
 tcacgatacc attgccagag ttgtatcctg tatctgtcct gcgaaatttc atgagagctt    300
 tattaactgg atgcttgact accattcttc agatgataaa gacgtcatcg caattgatgg    360
 aaaaatacac cggcattctt atgacaagag tcgccgtaag ggagcgattc atgtcattag    420
 tgcgttctca acaatgcaca gtctggtcat cggacagatc aagacgtcag ctccggggca    480
 gagtggagga ggaggtgtgc acagaggcac cattgttgtg ggaagcaatt tgttggtgag    540
 gagggagctg cggtcctgca tgacatccac acgtgtgaca tccacacgcg tgaaatcagc    600
 acacacgcgt gacatccaca cgcgtgacac ccacatgcgt gacaccagca cacacgtgac    660
 atccacgcac atgacatcag cacacacgtg tgacatccac acgcgtgaca tcagcacacg    720
 tgtgccattc acacatgtga cattagccaa ggtactaact caatctcagc cggtcacggt    780
 ggtttacgcc tttaaatcca acaactttgc gaggtggaga cagaggatcc ccaagcgtat    840
 cgcctttgtt tgcgatgcgg ggatgggctc cagtgcgatg ggcgcgacca ccttccgtaa    900
 acgcctggaa aaagcggggc tggcaattga agtaaaacat tacgccatag aaaacgtgcc    960
 tgcggatgcg gatatcgtcg ttactcatgc cagtctggaa gggcgcgtga aacgtgtgac   1020
 ggataaacca ctgatattga ttaataacta tattggcgat ccaaaactcg acactttatt   1080
 taatcaatta accgccgaac ataaacactg attacagagg taaaaatgaa aaccaaagtt   1140
 gctgctattt atggcaagcg ggatgtccgt ctgcgcgtat ttgaactgcc agaaattacc   1200
 gataatgaat tactggtgag tgtaatttct gacagcgtct gtttatcgac ctggaaagcg   1260
 gcgttactcg gtagtgaaca taaacgcgta cccgacgatt tagaaaatca tccggtcatt   1320
 accgggcatg aatgtgccgg ggttattgtc gaagtggaac agaggctcgt ggtaacgcgt   1380
 acagagatgg tacatccctg tcctctcatc aaagtgattc ctctcccttt tgccaaactt   1440
 ccacagaagc caaataaaca gtgtagacac tccgtcactc gctacggcca cggcggccac   1500
 tcggatcaca ctccgtcact cactgtggcc acagtggcca ctcagatcac accccgtcac   1560
 tcgggccacg gcagccactg tgatcgcaac ctgtcacttg ctacagccac agcagccact   1620
 ctgatcacac cccatcactt gctatggcca cgatggcccc ttggatcaca ctctgtcact   1680
 tggtgtggcc acggtggcca ctcggatcac actccatcac ccactacggc cacagcagtc   1740
 actcggatca catcccgtca cccactacgg ccacagcagt cactcggatc acatcccgtc   1800
 actcactaca gccatggcag ccactctgat tgcattcccg tcactcgcta tgcccacggc   1860
 ggccactcag atcacactcc atcacttgct atggccacgg cagccactca gatggcactc   1920
 tgtcactcac tatggccacg gcagccactt ggatacttgg tcaataaaat aagaaggtca   1980
 aacatttacc ctgtgtga                                                 1998



      <210> 2375
      <211> 417
      <212> DNA
      <213> Homo sapiens


      <400> 2375
 aacgatttcg tgcagccgcc attgtccgcg gctgaagttg ggatttgctg tgttcctggg     60
 caggtgcctg gtcaatcagt cctcgggatg gcagccatca acccgtgggc ctcctggggt    120
 gcccttacgg accaatcttg ggggatgaca gctgttgacc catgggcctc ctgggctctg    180
 tgtcctcagt atcctgcctg gcacgtggag ggaagcctgg aggaggggag gagggccact    240
 gggctcccag cagcccaggt tcaggaacca gtgaccttca aggacgtggc cgtggacttc    300
 acccaagaag agtgggggca gctggacctt gttcagagga ccctgcaccg tgatgtgatg    360
 ctggagacct atggtcacct gctctctgtg ggaaatcaga ttgccaagcc tgaggtc       417



      <210> 2376
      <211> 655
      <212> DNA
      <213> Homo sapiens


      <400> 2376
 cagaggttca aaaacgactg tagagaccct cgggatactg ggccaataca tggactatgg     60
 cccgataaaa gtgaaggagt aatagatcgt ggccttcaat ttagaagaga ttaaggatct    120
 ttgcccagaa atgagggcat actggcctga cgtaattcac tcgtttccca atcgcagccg    180
 cttctggaag catgagtggg aaaagcatgg gacctgcgcc gcccaggtgg atgcgctcaa    240
 ctcccagaag aagtactttg gcagaagcct ggaactctac agggagctgg acctcaacag    300
 gttgcagatt ttaaagatgc ccttgccaga gtatatggag tgatacccaa aatccagtgc    360
 cttccaccaa gccaggatga ggaagtacag acaattggtc agatagaact gtgcctcact    420
 aagcaagacc agcagctgca aaactgcacc gagccagggg agcagccgtc ccccaagcag    480
 gaagtctggc tggcaaatgg ggccgccgag agccggggtc tgagagtctg tgaagatggc    540
 ccagtcttct atcccccacc taaaaagacc aagcattgat gcccaagttt tggaaatatt    600
 ctgttttaaa aagcaagaga aattcacaaa ctgcagcttt ctaaaaaaca aaaaa         655



      <210> 2377
      <211> 416
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> misc_feature
      <222> (1)...(416)
      <223> n = a,t,c or g


      <400> 2377
 ccgagcactg ggacttcaac gccaccatct ccaagactcg gtttggggtg aaagatggcg     60
 ctgactgggt acagctggct gctcctcagt gccacattcc tgaatgtggg ggccgagatc    120
 tctatcaccc tggagcctgc ccagccgagc gaaggggaca acgtcacgct ggtcgtccat    180
 gggctttcgg gggaactgct cgcctacagc tggtatgcgg ggcccacact cagcgtgtca    240
 tacctggtgg ccagctacat cgtgagcaca ggcgatgaga ctcctggccc ggcccacacg    300
 gngcgggagg ctgtgcgccc cgatggcagc ctggacatcc agggcatcct gccccggcac    360
 tcaagcacct acatcctgca gaccttcaac aggcagttgc agaccgaggt gggctn        416



      <210> 2378
      <211> 841
      <212> DNA
      <213> Homo sapiens


      <400> 2378
 tttttttttt ttacaaaatg tgtatattaa tagctttgca caaatatttt aaagacaaat     60
 tcagctagtc taagaacttc atgaaaataa aacaggtgga taaatacttc atgtgcacaa    120
 tgcactccat cagacgtcgt cggctgggag aggaggtatg ttgatccttg gccttgtgaa    180
 gaatgctatc ttctccctaa aggtctgcac ttggatgggc tctttgtggc tctgcccacg    240
 cagctggtag atctccttgg aggccttctt cagcatcttc tcagccgcct gctcatgacg    300
 gtagtcaagt ttggtctgtc ttgtctgccg ctcggcctcc cgcagcaggc cacggagccg    360
 ctcgtcccga agcacccagg gtgggaggtc agtctggcca cggagctggg cgtcctccaa    420
 ccgctgccgc agctcacgga gggcgcagag ctcctcattc agctgcctct gccgtgttct    480
 cgacgcctgg agatccagct ccaagtccag ggaggtgcgg gccatgagct cagccaggga    540
 agacctgcat gactgcaaga gacgccagct gtgagccctc actcaggcct tctagaaggt    600
 tcttccacaa ttaataggag acaggtcagg cacacgtatt tctctaagca cgcccaaggt    660
 taaaaaacac agatgtgggc aagagaaatg taaatctcta gttcagtatc aaggttagta    720
 acagcaaatt gtttttcttt aatgatgacc tatgtattgg cagaaatgtg cagcaacaga    780
 tgctcttata tggggctggc aggatcaaaa atggaacaat ctttatgaag ggccatttga    840
 g                                                                    841



      <210> 2379
      <211> 5799
      <212> DNA
      <213> Homo sapiens


      <400> 2379
 atgactcctg aatcaaggga tactacagat ttgtctccag ggggtaccca ggagatggaa     60
 ggcatcgtga tagtgaaggt ggaggaggaa gatgaagaag accattttca aaaggaaaga    120
 aacaaagtag agtcatcgcc acaagttctc agtcgctcta caactatgaa tgagagagcc    180
 ttattgtcat cgtatttagt tgcatataga gtggcaaaag agaaaatggc tcacacagcg    240
 gctgaaaaaa ttatccttcc agcatgtatg gacatggtac ggacaatttt tgatgacaaa    300
 tcagctgata aactaagaac tatacctctt agtgataata caatatctcg tcgaatctgt    360
 acgattgcaa aacatttgga agcaatgctt attacacggc tgcagtccgg tatagacttt    420
 gcaatccaac tcgatgagag cactgatatt gcaagttgtc ccacactctt ggtttatgtc    480
 agatatatcc cgctgaaatt acgcttagga ggacttcttc aaccagaaaa acccattgtt    540
 ctaaaggttg agtcaaggga tgggaccatt cagtacaact ctcaacagca cataaatctt    600
 tcagcagctt ggctgaagac tgctgtgcag ggcagggaag ctccaggcaa acagcccagc    660
 aaacagcagc actcagctaa aaggaagact cacagaacac agttgaagaa ggaaagtggc    720
 gatggacctc atcccaaatt tggcggtgga aacctggctt ctcctggctg tcagcctggt    780
 gctcctctat ctagatactt cacgtacaga ggcagtgaac tgactgcttt ctggttgacc    840
 accttgaaaa agatgagtgt gcctggcact gtgcttctca gatatgggac ccgtacacat    900
 ggacttttta agagactggg aattccaggg cccacacctc tgcctttgtt gggaaatgtt    960
 ttgtcctatc gtcagaagtt ggtgaaaatt gaagaggtgg ctgatgtggc tgtatccttc   1020
 atcctggagg aatgggggca tttggaccag tcccagaagt ccctttatag ggatgacagg   1080
 aaggagaact atgggagtat tacttccatg ggttatgagt ccagggacaa tatggagctc   1140
 atagtgaagc agatttctga tgactctgaa tcacactggg tggcgccaga acacaccgaa   1200
 aggagcgttc ctcaggatcc agactttgca gaagtcagtg accttaaagg catggtacaa   1260
 aggtggcagg tcaaccccac tgtggggaaa tcaaggcaga atccttccca gaaaagggat   1320
 ctggatgcaa tcacagacat cagccctaag caaagcacac atggcgagag agggcacaga   1380
 tgcagcgatt gtggcaaatt cttcctccaa gcctcaaact ttattcagca tcggcgcatc   1440
 cacactggag aaaaaccgtt taagtgcgga gaatgtggga agagctacaa tcagcgggtg   1500
 cacctcaccc agcaccagcg cgtccacaca ggggagaaac cctacaaatg tcaggtgtgc   1560
 ggaaaggctt tccgggtgag ttcccacctg gttcagcacc acagtgtcca cagcggagag   1620
 aggccctatg gctgcaatga gtgtgggaag aacttcggtc gccattcgca tctgatcgaa   1680
 cacctaaaac gccacttcag ggagaaatcc cagagatgca gtgacaaaag aagtaagaac   1740
 acaaaattaa gtgttaagaa gaaaatttca gaatattcag aagcagacat ggaactatct   1800
 ggaaaaaccc aaagaaatgt ttctcaagtt caagattttg gagaaggctg tgagtttcaa   1860
 ggcaagctgg atagaaagca gggaattccc atgaaagaga tactaggaca accatcttca   1920
 aagaggatga actacagtga agtcccatat gtccacaaaa aatcctccac tggagagaga   1980
 ccacataaat gtaacgagtg tgggaaaagc ttcattcaga gtgcacatct tattcaacat   2040
 caaagaatac acactgggga gaaaccattc aggtgtgagg aatgtgggaa aagctacaac   2100
 caacgcgtgc acctaactca gcatcagcgc gtccacacag gtgagaagcc ctacacctgt   2160
 cccttatgtg ggaaagcctt cagagtgagg tcccaccttg ttcagcatca gagcgtgcac   2220
 agtggggaga gacccttcaa gtgtaacgaa tgtgggaaag gctttgggag gcgttcccac   2280
 ctggctggac atcttcgact ccactcccga gagaaatccc atcagtgtcg tgaatgtggg   2340
 gaaatctttt ttcagtacgt tagcctaatt gaacatcagg tgctccacat gggtcagaaa   2400
 aatgaaaaaa atggcatctg tgaggaagca tatagttgga acttgacagt gattgaagac   2460
 aagaagattg agttacaaga gcagccttat cagtgtgata tctgtggaaa agcctttggt   2520
 tatagctcag acctcattca gcattacaga actcatacag cagagaagcc ctatcaatgt   2580
 gatatatgta gagaaaatgt tggccagtgt tcccacacca aacaacatca aaaaatctac   2640
 tccagcacaa aatcccatca atgtcatgaa tgtggcagag gcttcactct gaagtcacat   2700
 cttaatcaac atcagagaat ccatactgat cgcgactgtg gccgaggcag gggcaccagc   2760
 aaccagtggc gctcagtgaa gggcaggctg ggtctgttcc gccatttgcc ggaccggggt   2820
 ggccgagccg aggacctgga ggagaagcgc cctgcgccct cgacatctct gaatagcttc   2880
 cttcaactgc cagtgaaaga tagcaggcct gatttcattg gacgcaactg ttttcagccc   2940
 caattagagg gtctctggaa atttgacaca gagtgctata aaaagtatgg aaaaatgtgg   3000
 ggaacgtatg aaggtcaact ccctgtgctg gccatcacag atcccgacgt gatcagaaca   3060
 gtgctagtga aagaatgtta ttctgtcttc acaaatcgaa ggatgttccc catcattgcc   3120
 cagtatggag atgtattggt gagaaacttg aggcgggaag cagagaaagg caagcctgtc   3180
 accttgaaag acatctttgg ggcctacagc atggatgtga ttactggcac atcatttgga   3240
 gtgaacatcg actctctcaa caatccacaa gacccctttg tggagagcac taagaagttc   3300
 ctaaaatttg gtttcttaga tccattattt ctctcaataa tactctttcc attccttacc   3360
 ccagtttttg aagcattaaa tgtctctctg tttccaaaag ataccataaa ttttttaagt   3420
 aaatctgtaa acagaatgaa gaaaagtcgc ctcaacgaca aacaaaagag gccagccgaa   3480
 ggatgtctgc aggtcaggga gacaggacca ggtaacccag ctgtcactga agattatata   3540
 gagtttgaga atgttggaat atttgaaaat gctcccccaa aaaagctgct gatgagttct   3600
 ggaaatgtca ggagattaat ctatacggac actgctgaag aaaaagctct gtctgatctg   3660
 gagctcgcag cccagtcaat aatcttcatt tttgctggct atgaaaccac cagcagtgtt   3720
 ctttccttca ctttatatga actggccact caccctgatg tccagcagaa actgcaaaag   3780
 gagattgatg cagttttgcc caataaggaa cgcagctccg caccagcaac ggaaagctgg   3840
 atggagaatg actttgacga gttgagagaa gaaggcttca gacgatcaaa ctactccgag   3900
 ctaaaggagg aagttcgaac ccatggcaaa gaagttaaaa accttgaaaa aagattagac   3960
 aaatggctaa ctagaataat caatgcagag aagtccttaa aggacctgat ggagctgaag   4020
 accatggcac gagaactacg tgatgaatgc acaagcctca gtagccaatt caatcaactg   4080
 gaagaaaggg tatcagtgat ggaagatcaa atgaatgaaa tgaagaaaga agagaagttt   4140
 agaagaaaaa gaataaaaag aaaggaacaa agcctccaag aaatatggga ctatgtgaaa   4200
 agaccaaatc tacgtctgat tggtgtacct gaaagtgacg gggagaatag aacgaagttg   4260
 gaaaacactc tgcaggatat tatccaggag aacttcccca atctagcaag gcaggccaac   4320
 attcaaattc aggaaataca gagaacgcca caaagatact cctcgagaag agcaactcca   4380
 agacacataa ttgtcagatt caccaaagtt gaaatgaagg aaaaaatgtt aagggcagcc   4440
 agagagaaag aaatacaaac taccatcaga gaatactata aacacctcta tgcaaataaa   4500
 ctagaaaatc tagaagaaat ggataaattc ctcgacacat acactctccc aagactaaac   4560
 caggaagaag ttgaaactct gaatagacca ataacaggtt ctgaaattga ggcaataatt   4620
 aatagcttac caaccaaaaa aagtccagga ccagatggat tcaccgccga attctaccag   4680
 aggtacaagg aggacctggt accattcttt ctgaaactat tccaatcaat agaaaaagag   4740
 ggaatcctcc ctaactcatt ttatgaggcc agcatcatcc tgataccaaa gcctggcaga   4800
 gacacaacca aaaaagagaa ttttagacca atatccctga tgaacagtga tacaaaaatc   4860
 ctcaataaaa tactggcaaa ccgaatccag cagcacatca aaaagcttat ccaccatgat   4920
 caagtgggct tcatccctgg gatgcaaggc tggttcaaca tacgcaaatc aataaacata   4980
 atccagcata taaacagaac caacgacaaa acccacatga ttatctcaat agatgcagaa   5040
 aaggccttta acaaaattca acagcccttc atgctaaaaa ctctgaataa attagtgttg   5100
 gaagttctgg ccagggcaat caggcaagag aaagaaataa agggtattca attaggaaaa   5160
 gaggaagtca aattgtccct gtttgcagat gacatgattg tatatctaga aaaccccatc   5220
 gtctcagccc aaaatctcct taagctgata aacaacttca gcaaagtatc aggatacaaa   5280
 atcaatgtgc aaaaatcaca aatattctta tacaccaata acagacaaac agagagccaa   5340
 atcatgagtg aactcccatt cacaattgct tcaaagacaa taaaatacct aggaattcaa   5400
 cttacaaggg atgtgaagga cctcttcaag gagaattaca aaccactgct caatgaaata   5460
 aaagaagata caaacaaatg gaacaacatt ccatgctcat gggtaggaag aatcaatatc   5520
 atgaaaatgg ccatactgcc caaggtaatt tatagattca gtgccatcgc catcaagcta   5580
 ccaatgactt tcttcacaga actggaaaaa actactttaa agttcatatg gaaccaaaaa   5640
 agagcccgca ttgccaagtc aatcctaagc caaaagaaca aagccggagg catcatgcta   5700
 cctgacttca aactatacta caaggctaca gtaaccaaaa cagcatggta ctggtaccaa   5760
 aacagagata ttgatcaatg gagcagaaca gagccctga                          5799



      <210> 2380
      <211> 1138
      <212> DNA
      <213> Homo sapiens


      <400> 2380
 atgactcaga taagtaacat aaagcagcct tttgccatgc agcacaggtt cttcatttcc     60
 cttttgcact ggaccctgca aattgtgtat ccagcactgt tcctaggact ttgtgaacgg    120
 ggaagaaatg ggaggtgtga tcaagtacca gaaggctctg tgctgtctct gctggtctgg    180
 gtggttcctg gactggcgtt ccctgaggtt gcacctggca cgtgtggcac cagctatgtt    240
 cctgatgctg gactccatgg tcctgaagtg gaatcaaaac tggggcttga ccccggatcg    300
 atgactggga ctcagcctac gcggacgcca gcgcagcctg cggcggccga gccacctgcc    360
 ctcacagggc ctggccgggt gcatcaggaa caggcggtct tagcgtgtgg atttctgggc    420
 atttaccact tgggggcagc atctgcactt tgcagacatg gcaaaaaact tgtgaaggat    480
 gtcaaagcct tcgctggggc gtctgcggga tcgttggttg cttctgttct gctaacagca    540
 ccagaaaaaa tagaggaatg taaccaattt acctacaagt ttgccgaaga aatcagaagg    600
 cagtctttcg gggcagtaac gcccggttat gacttcatgg cccgactaag aagtgggatg    660
 gagtcgattc ttcctcccag cgctcacgag ctggcccaga accgactgca cgtatccatc    720
 accaacgcca aaaccagaga aaatcactta gtctccactt tttcctccag ggaggacctc    780
 attaaggtcc tcctagccag cagttttgtg cccatttatg caggactgaa gctagtggaa    840
 tacaaagggc agaagtgggt ggacggaggc ctcaccaacg ctcttcccat tcctgcccgt    900
 cggccggaca gtaaccatct cccccttcag tggacgactg gacatctccc cgcaggacaa    960
 agggcagcta gatctgtatg ttaatatcgc caagcaggat atcatgttgt ccctggcaaa   1020
 cctggtgaga ctcaaccaag ccctttttcc cccaagcaag aggaaaatgg aatctttgta   1080
 tcagtgtggt tttgatgaca ctgttaagtt tttacttaaa gaaaattggt ttgaataa     1138



      <210> 2381
      <211> 1140
      <212> DNA
      <213> Homo sapiens


      <400> 2381
 tgactctgct ctctgtcctg tctcctcatc tgcaaaatta ggaagcctgt cttgattatc     60
 tccaggaacc tcccaccttt tcattccagc ctctgacaaa ctctgcacat taggccagga    120
 gaagcccccg agccaagtct cttttctcat tctcttccaa caagtgcttg gagctccaag    180
 aaggccccct ttgcactatg agcaaccagg tgctctgctg tgtggtcctt tgtttcctgg    240
 gagcaaacac cgtggatggt ggaatcactc agtccccaaa gtacctgttc agaaaggaag    300
 gacagaatgt gaccctgagt tgtgaacaga atttgaacca cgatgccatg tactggtacc    360
 gacaggaccc agggcaaggg ctgagattga tctactactc acagatagta aatgactttc    420
 agaaaggaga tatagctgaa gggtacagcg tctctcggga gaagaaggaa tcctttcctc    480
 tcactgtgac atcggcccaa aagaacccga cagctttcta tctctgtgcc agtagtatag    540
 gggcagggct cccttatagc aatcagcccc agcattttgg tgatgggact cgactctcca    600
 tcctagagga cctgaacaag gtgttcccac ccgaggtcgc tgtgtttgag ccatcagaag    660
 cagagatctc ccacacccaa aaggccacac tggtgtgcct ggccacaggc ttcttccctg    720
 accacgtgga gctgagctgg tgggtgaatg ggaaggaggt gcacagtggg gtcagcacgg    780
 acccgcagcc cctcaaggag cagcccgccc tcaatgactc cagatactgc ctgagcagcc    840
 gcctgagggt ctcggccacc ttctggcaga acccccgaaa ccacttccgt tgccaagtcc    900
 agttctacgg gctctcggag aatgacgagt ggacccagga tagggccaaa cccgtcaccc    960
 agatcgtcag cgccgaggcc tggggtagag cagactgtgg ctttacctcg gtgtcctacc   1020
 aacaaggggt cctgtcttgc caccatcctc tatgagatcc tactagggaa ggccaccctg   1080
 tatgctgtgc tggtcagcgc ccttgtgttg atggccatgg tcaagagaaa ggatttctga   1140



      <210> 2382
      <211> 401
      <212> DNA
      <213> Homo sapiens


      <400> 2382
 cgagagtggg aatgtatccc aggagtccgg ccccacctat gcctcattct ctcaccattt     60
 catcagtgat gcaatgacag gtgtgcccac tgagaatgat gacttttgca ttctttttgc    120
 accaaaagca gccatgcagg agaaggaaga agaaccagtt ataaaaatca tggttgatga    180
 tgcaattgtg ataagagaca attatttcag tctgcccgtt aataagaccg atacgagcaa    240
 agccccctta cactttccca ttcctgtgat tcgctatgtg gtgaaggagg tctctcttgt    300
 ctggcatctt tatggaggaa aggattttgg aacagtccct cccacttctc cggctaaaag    360
 ttatattagt ccccacagtt cgccttctca cacacccacg a                        401



      <210> 2383
      <211> 1909
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> misc_feature
      <222> (1)...(1909)
      <223> n = a,t,c or g


      <400> 2383
 agttcctaaa ttgggggaaa catagtgaat tccacataat gttttaaatt attcagccac     60
 taaaaataaa tttacatatg atttcattaa tatattcact atctaaacca tattttttac    120
 actacgtaaa atacattgta tatgtacagt gagtgatgct ttttgcttta gttctcattt    180
 ttcacattaa ggggaggaaa gctacccata gatagtattc ttactccttt tcacatgctt    240
 caaggacagt ttgcaagtgg atataaatac atacacatca ctagtgatta tgcttttatg    300
 ttatttccaa cttcttatag gtaacataat tttcagacaa tgttagctgg ttttaaaccc    360
 aatcagtaaa ctggcattaa aggattctta ataaaccaaa cactgaaggc ctctttcata    420
 tttgtatcat ctgcattttt ttttatatgc ttgtcatgtg gctttacttt cagcctcact    480
 cttttcttct tccaaatgga ttatccttaa accttttacc tttaaagagc ctgagattta    540
 tatttaactc gaacaacagt ttgcctctgt tgcccctgtg ttcatgtttt cctaagccag    600
 agtttcccac gcctcctgtt cctggcagcc caagtgcctt cgctgggcta ctcccacctg    660
 gcccttgctt ttcattcctt agggcagtca cttagcacct tccaaagtgc ctgcacatgt    720
 ttcttatttc atttcttaaa cattcatatt accactattt agattgaagg aacagaattg    780
 gtttgggctt gaagagaata caaagagatc tgtcttcaat tatctgatag tagtaaagtt    840
 tcacgggaga aagaaagatt tcggttccac ataaggaaaa acttggaaag ttttgaatgg    900
 aaagttcata gagagattca gtaaccacct gtcaggaatt ttgtaaagac gtctacggcc    960
 atatcaccct gaacgcgcct gatctcatct gatctcggaa gctaagcagg gtcgggcctg   1020
 gttagtactt ggatgggaga aattttataa agaacacatg aacactagct ggcctatgtg   1080
 gcctttaaaa tctcttccaa tcctgagatt cccacaactc tggataaaaa ggggcaaaag   1140
 tattagacat ttcactccca ttaatatgag ggaagtaaat gacattgagg tccaatttgt   1200
 ctgtagttca gaattagtcc aatacagacc cttagaccaa ctagggaaca aaaagcaagc   1260
 atttcaagtt acctataagc ctgggctcat cagaatatag aaacagccat gtgctagctg   1320
 aaagccattc aatgaggctt tctattaatt tcctttaaaa gcaatggtta ttattgaaac   1380
 tcctaaatgc taaaatctga aggacccatc cttatatata agttctgatc atactgaaac   1440
 agtcatttag caacattgct ctgatgtcca ggaccctggt ctgtaatgaa agcaatgaag   1500
 ggaggggctg gcagggcact actggggtgg tataggggac actgcttata ttcacaaggc   1560
 cacgtggtcc aagcatagcg gagagcaacc acagtgccat gacaagaatc gatcgccagg   1620
 gtcagggact gggtggagac ggtgttcata gaagctggaa gccacttgca tcgatggtca   1680
 ctgcaacagg agatctcaaa tatcttgttg tcctttttct gcacctggat ttgctggtaa   1740
 tatgtgagat tgagcagccc cttgtgagcc aagagttcta tcttctcagg cagtggtcct   1800
 tcaaaggtca aattcttctc accataagcc agagcacggg cccccaaatg cagccgataa   1860
 gccacagtct gtttatctcg gcccggtaat tccaacccgg ntgacgtca               1909



      <210> 2384
      <211> 1386
      <212> DNA
      <213> Homo sapiens


      <400> 2384
 atgacatcag actgccagct tggcacgagg caatatctgt gtcgttcttg gcagaaatta     60
 tattttccag cccgtgtctg caggtatatt cgaattgttg ggactcacaa cacagtgaac    120
 aagatttttc acattgtggc ttttgaatgt atgtttacaa acaaaacctt cactcttgag    180
 aaggggctga taggttacta ctttgggatt gtgacactca aagtggacac agtggaacac    240
 ctgggagaga aaaggaaaag accccatgag tgaagggtca gcatgcggcc ctggagttgc    300
 cgcaagttgg gatactgccc tgcccagctt tgggggccac cacgagggag ttagaggagg    360
 tccttcccac tgcccacgcc tgccccggcg cagacacctg atggcaacta gcatgctgta    420
 aacacatttt gatcagtcaa gaggaaagga aattgagcca gtggcccaaa agttagagac    480
 accatgacac gggtttccca caaaatcttt cacactggat tacttccgtt tttgccaacc    540
 tttgtctaat tgggctcttt ttttcttttt taattaattt tttgtatttt ggcagtttgg    600
 gttaaaagtc aacaggagtt gactgggtgg tggtggtggt ggtggttcga ttctgtgagg    660
 ttgtggaaag caggtccaca gataacgtcc accatctgtg tggcatctgc gtgggttgtc    720
 tctgggtatt ctggttttct cccgcgtccc aaagctgtgc acttgaggtt cattggtgtg    780
 tctgcagggt cccagtctga gtgcatgtga atgtgtgtga gcgtgccctg caatggcatg    840
 gtgtcctgtc ctgagctggt tcctgatgca tagttctcct ggccctgcaa tggttgagca    900
 cagaccctgc taagcagccg tgctggggag tggacttcaa cctcatgtgg ctccagccag    960
 cctggaacaa acgccctcaa tgtgtagaag ccagccacct ggccgacagt caccctctag   1020
 gagctaagaa gagtttgcat acctgacagc aggtcagccc tggaagcacc atgaactctg   1080
 tgcccaacac cgtgccagca ctgtgcagac cagggcacag caccgagctc agcgccccgc   1140
 aagcaagggt aagccatggc cctgacctgg agagtagaca acgtgcttcg gggggtcctg   1200
 acatgcatgt gtgagctgtg gggtgcagga gagaagggcg gggtgggggc tgtcgttgcc   1260
 actgcacgag catgtgtgca catacataca cacggccttc taccgtagaa tcaagttcac   1320
 agagacaaat gtagtatcaa ctgcagaatt atattgaaaa tataaattcc acgcttaaaa   1380
 aaaaaa                                                              1386



      <210> 2385
      <211> 1127
      <212> DNA
      <213> Homo sapiens


      <400> 2385
 agccaggcag cacatcacag cgggaggagc tgtcccaggt ggcccagctc agcaatggca     60
 atgggggtcc ccagagtcat tctgctctgc ctctttgggg ctgcgctctg cctgacaggg    120
 tcccaagccc tgcagtgcta cagctttgag cacacctact ttggcccctt tgacctcagg    180
 gccatgaagc tgcccagcat ctcctgtcct catgagtgct ttgaggctat cctgtctctg    240
 gacaccgggt atcgcgcgcc ggtgaccctg gtgcggaagg gctgctggac cgggcctcct    300
 gcgggccaga cgcaatcgaa cgcggacgcg ctgccgccag actactcggt ggtgcgcggc    360
 tgcacaactg acaaatgcaa cgcccacctc atgactcatg acgccctccc caacctgagc    420
 caagcacccg acccgccgac gctcagcggg ctcgagtgct acgcctgtat cggggtccac    480
 caggatgact gcgctatcgg caggtcccga cgagtccagt gtcaccagga ccagaccgcc    540
 tgcttccagg gcaatggcag aatgacagtt ggcaatttct cagtccctgt gtacatcaga    600
 acctgccacc gggccctcct gcaccacctg atgggcacca ccagcccctg gacagccatc    660
 ggacctccaa ggggctcctg ctgtgagggg tacctctgca acaggaaatc catgacccag    720
 cccttcacca gtgcttcagc caccacccct ccccgagcac tacaggtcct ggccctgctc    780
 ctcccagtcc tcctgctggt ggggctctca gcatagaccg cccctccagg atgctgggga    840
 cagggctcac acacctcatt cttgctgctt cagcccctat cacatagctc actggaaaat    900
 gatgttaaag taagaattgc actcctgtcc ctctggcctt ccatctctcc cgcccttgtg    960
 ccccacaacc tggccaacag tactggaaga aactggacac agtcaccagc atcccagggg   1020
 agggcaaaac agccatgtcg tgccctgatg aagagcaatt ctgatcacag ctgttactca   1080
 ctgagcacca gccaggcacc aggcacccca taacacggct tcctgtg                 1127



      <210> 2386
      <211> 1657
      <212> DNA
      <213> Homo sapiens


      <400> 2386
 atgggtacag tccccaggtc tgcaggacag gaaacgtggg tcctgtgtga acacataatc     60
 gggggagagc gctcattcac tgagtactcg ctatgccatc ggattgaatc ctccactagc    120
 tcgataaagc tggagttagg gggtaacaac gtggagcctc tggagagctc aagggttttt    180
 gattcaacag tccaaaatga ggaggcagat gcagttagca ctggagagga gggagttacc    240
 catgagggaa cccagggagg aaaagttatt cctcaaatgc acatgggctc cgggctgcag    300
 cccaagagct tcagccaaaa caggagccaa gttaataacg acatgatagt cactgacaac    360
 aacggtgcag tcaagtttcc acaactgtgt aaattttgtg atgtgagatt ttccacctgt    420
 gacaaccaga aatcctgcat gagcaactgc agcatcacct ccatctgtga gaagccacag    480
 gaagtctgtg tggctgtatg ctggatgagt gaggagattt gtaccaacgt catgtattct    540
 cctcttccct gcaaattcct ccacctgagt cctattgagg tgctccccat tataaggagt    600
 cctgtgaatc aaagtggtag atgtaaaatc agacatatag gttcaaacaa tcgattgcaa    660
 aggagcactt gtcaaaacac tggctgggaa tctgctcatg tgatgaagac cccagggttt    720
 agagaatata acaccagcaa tcctgacttg ttgctagtca tatttcaagt gacaggcatc    780
 agcctcctgc caccactggg agttgccata tctgtcatca tcatcttcta ctgctaccgc    840
 gttaaccggc agcagaagct gagttcaacc tgggaaaccg gcaagacgcg gaagctcatg    900
 gagttcagcg agcactgtgc catcatcctg gaagatgacc gctctgacat cagctccacg    960
 tgtgccaaca acatcaacca caacacagag ctgctgccca ttgagctgga caccctggtg   1020
 gggaaaggtc gctttgctga ggtctataag gccaagctga agcagaacac ttcagagcag   1080
 ttttgagaca gtgggcagtt caagattctt ttccctattg agggagtatg cctcttggaa   1140
 gacagagaag gacatcttct cagacatcaa tctgaagcat gagaacatac tccagttcct   1200
 gacggctgag gagcggaaga cggagttggg gaaacaatac tggctgatca ccgccttcca   1260
 cgccaagggc aacctacagg agtacctgac gcggcatgtc atcagctggg aggacctgcg   1320
 caagctgggc agctccctcg cccgggggat tgctcacctc cacagtgatc acactccatg   1380
 tgggaggccc aagatgccca tcgtgcacag ggacctcaag agctccaata tcctcgtgaa   1440
 gaacgaccta acctgctgcc tgtgtgactt tgggctttcc ctgcgtctgg accctactct   1500
 gtctgtggat gacctggcta acagtgggca gtgctatgaa gtatgctcca gtggacgttt   1560
 tcttgtaacg atatttaagg ggaacaggtt aagagaaagg acagagaaaa acactcgcat   1620
 aactcctcga gactgggttt atgagtggtt atggtga                            1657



      <210> 2387
      <211> 2321
      <212> DNA
      <213> Homo sapiens


      <400> 2387
 tctagcctgg atgacagagc aagactccat ctcattaaat aaataaataa ataaatattc     60
 aacaacttaa gaaatggggt aagtagttct tatctgttgt ttgcttaaga gtatgagaat    120
 catcgatcct catgctattg ctgatctgaa ttgcttttaa ctttttcttt cagattaaga    180
 atgacccaaa ataaattaaa gctttgttcc aaagccaatg tgtatactga agtgcctgat    240
 ggaggatggg gctgggcggt agctgtttca tttttcttcg ttgaagtctt cacctacggc    300
 atcatcaaga catttggtgt cttctttaat gacttaatgg acagttttaa tgaatccaat    360
 agcaggatct catggataat ctcaatctgt gtgtttgtct taacattttc agctcccctc    420
 gccacagtcc tgagcaatcg tttcggacac cgtctggtag tgatgttggg ggggctactt    480
 gtcagcaccg ggatggtggc cgcctccttc tcacaagagg tttctcatat gtacgtcgcc    540
 atcggcatca tctctggtct gggatactgc tttagttttc tcccaactgt aaccatccta    600
 tcacaatatt ttggcaaaag acgttccata gtcactgcag ttgcttccac aggagaatgt    660
 ttcgctgtgt ttgctttcgc accagcaatc atggctctga aggagcgcat tggctggaga    720
 tacagcctcc tcttcgtggg cctactacag ttaaacattg tcatcttcgg agcactgctc    780
 agacccatct ttatcagagg accagcgtca ccgaaaatag tcatccagga aaatcggaaa    840
 gaagcgcagt atatgcttga aaatgagaaa acacgaacct caatagactc cattgactca    900
 ggagtagaac taactacctc acctaaaaat gtgcctactc acactaacct ggaactggag    960
 ccgaaggccg acatgcagca ggtcctggtg aagaccagcc ccaggccaag cgaaaagaaa   1020
 gccccgctat tagacttctc cattttgaaa gagaaaagtt ttatttgtta tgcattattt   1080
 ggtctctttg caacactggg attctttgca ccttccttgt acatcattcc tctgggcatt   1140
 agtctgggca ttgaccagga ccgcgctgct tttttattat ctacgatggc cattgcagaa   1200
 gttttcggaa ggatcggagc tggttttgtc ctcaacaggg agcccattcg taagatttac   1260
 attgagctca tctgcgtcat cttattgact gtgtctctgt ttgcctttac ttttgctact   1320
 gaattctggg gtctaatgtc atgcagcata ttttttgggt ttatggttgg aacaatagga   1380
 gggactcaca ttccactgct tgctgaggat gatgtcgtgg gcattgcaga agatgtcttc   1440
 tgcagctggg gtctacatct tcattcagag catagcagga ctggctggac cgccccttgc   1500
 aggtttgttg gtggaccaaa gtaagatcta cagcagggcc ttctactcct gcgcagctgg   1560
 catggccctg gctgctgtgt gcctcgccct ggtgagaccg tgtaagatgg gactgtgcca   1620
 gcatcatcac tcaggtgaaa caaaggtagt gagccatcgt gggaagactt tacaggacat   1680
 acctgaagac tttctggaaa tggatcttgc aaaaaatgag cacagagttc acgtgcaaat   1740
 ggagccggta tgacacactt tcttacaaca acagccactg tgttggctgg agagggatgg   1800
 ggtgggccca acggggacac aaggaggcag aggagctaac ccctctactc cactttcaaa   1860
 actacatttt aaagggaatg tgtatgtgaa gagcactacc aaacatcgct tttgttttgt   1920
 tttgttttgt tttaagcttt tttttttttg cttgttttta aagccaaaac aaaaaacaac   1980
 caagcactct tccatatata aatctggctg tattcagtag caatacaaga gatatgtaga   2040
 aagactcttt ggttcacatt ccgatattaa aatagtgaca tgaactggca aagtggtttt   2100
 aaaagctttc acgtgggata aatgattttc tttttttctt ttctttcttc ctatggtctt   2160
 gtctgaataa actactctcc tgaataaaac aacatccaac ccaggtcatt gaaatgaaat   2220
 tggccagtca aaaaaaaaaa aggggggggc cctttaaaaa aaaaaaattt taacccccgg   2280
 gggggggaaa gaaatttttt ttttttgggg cccccaaaaa t                       2321



      <210> 2388
      <211> 1553
      <212> DNA
      <213> Homo sapiens


      <400> 2388
 tttcgtgttt tgaagaaggc ctccagaaca tctctggggc atggaggcaa tccaatccag     60
 atcctgcacc tgcccaccca gctggtcacc aattttacag ggggtcctga tgacaactta    120
 attgaaggtg gaggaacaaa atttgtctgc aaacctggag ccagaaacat taccgtcata    180
 ttccacccat tactaagatt tattcaggag attgagcatg ctctgggtct tggcccagcc    240
 aaacagtgtc ctcttcgaga gtttctcacc gtgtacatca aaaacatctt tctcaatcaa    300
 gtcttggctg agatcaacaa ggagattgaa ggagtcacta aaacatctga ccctttgaag    360
 attctggcca acgcagacac catgaaggtg ctgggagtgc agcggcctct cctacagagc    420
 acaatcattg tggagaagac agttcaagac ctcctgaacc tgatgcatga cttgagtgca    480
 tattcagatc aattcctcaa catggtgtgc gtaaagctcc aggagtacaa ggacacctgc    540
 actgcagctt acaggggtat tgtccagtca gaagaaaaac ttgtcatcag tgcatcctgg    600
 gcaaaagatg atgatatcag cagactcttg aaatctctac caaactggat gaatatggct    660
 caacccaaac agctgaggcc aaaaagagag gaggaagaag atttcataag ggcagctttt    720
 ggcaaggagt ctgaagttct tattgggaac ctgggtgata aattaatccc tccacaagac    780
 atccttcgtg acgtcagtga cctcaaagcc ttggccaaca tgcatgaaag cctggaatgg    840
 ttggcaagtc gaacaaagtc agctttctcc aatctttcta catcccagat gctttctcct    900
 gctcaagaca gccacacgaa cacggatctc cccccagtgt cagagcagat catgcagact    960
 ctcagtgaac ttgccaaatc gttccaggga tatgggctga ccgctgcttg cttgtcttac   1020
 atctgggaag tgagggttca ctgtttccac tatcttatcc ctcttggcaa aggaggggaa   1080
 ctatggccat tgtgggttaa tgtgggaaag tatggattat gaccccctgg tggtcaagct   1140
 caacaaagat atcagcgcca ttgaagaggc catgagcgcc agccttcagc agcacaagtt   1200
 ccagtatatc ttcgaaggcc tgggccacct gatctcctgc atcctcatta atggtgccca   1260
 gtacttcagg cgcatcagtg agtctggcat caagaaaatg tgtaggaaca tttttgttct   1320
 tcagcagaat ttgaccaaca tcaccatgtc gcgggaggca gacctggact ttgcaaggca   1380
 gtactacgag atgctttaca acacagctga cgagctcctg aacctggtgg tggaccaggg   1440
 tgtgaagtac acggagctgg agtacatcca cgctctgacc ctgctgcacc gcagccagac   1500
 tggggtgggg gaactgacca cccagaacac gaggctgcag aggctcaaag agg          1553



      <210> 2389
      <211> 563
      <212> DNA
      <213> Homo sapiens


      <400> 2389
 tttttttttt ttaaaactga aatgaatttt aatacagaaa atgaagacag gcattttgca     60
 aatttatcac tcaaaggggt atctctattt gaggaaatca gcgtgttaca ctttgaaaga    120
 tgaaatgtta cagcttgtac accaaaatta aaaaatgaaa ttaaattaaa aaatgaaatg    180
 gttaccaagg taatgcaggt caggggatca aaggtgaagg gtcacacatt attaaaaaga    240
 aatccaaaag gacggctgca tcatgatctc tcattagtgt tccagcggtg cctctctttt    300
 ggtaaacttg aacatttcgg cagacattca agcagctttt tcggtaaaaa gatttttaca    360
 tgactactat tgctgttccc atgatcatct tctataggtg gcacggtgtt gagaacacag    420
 taggtgctag ttccgcagaa tacactttgg gaaacgctct tccggcttgt tttcggcagc    480
 catttcccct ccgcgcgcca catcctcctc ctcctcgcga ccgggacccc gagcgcgcgc    540
 ctcgtaccgc cgccgccgcc ggc                                            563



      <210> 2390
      <211> 539
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> misc_feature
      <222> (1)...(539)
      <223> n = a,t,c or g


      <400> 2390
 attgagacgg tagaccatag tcagtgtggt ggaattcctg tcaagccagg gtgaaggatc     60
 cgtggccagg cagaggtctg tggagtggag aggcgaggcc tcacggtgga actctcagat    120
 gacagcatgc aggcaccaag agagtggacg cacatacaga agacagccat gcactgagct    180
 ggggacatgc aacaataaca ggtgagttcc aacaaattgg ttcaaaaaga ggggggataa    240
 acacgctggc ccatgctggg caagcatggc accaccttcc aggcactgtc ttcttctgat    300
 cagcactctg ggtgtctttg cacttaactg cttcaccaaa ggtcagaaga acagcacgct    360
 catcttcaca agggaaaaca ccattcggaa ctgcagctgt tctgcggaca tccgggattg    420
 tgactacagt ttggccaacc tgatgtgcaa ctgtaaaacc gtcctgcccc ttgcagttag    480
 gagcgaacca gctacaatgg gccttttgac cttntggttc acggacacat ttgcgttgg     539



      <210> 2391
      <211> 1826
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> misc_feature
      <222> (1)...(1826)
      <223> n = a,t,c or g


      <400> 2391
 gaattcggca cgaggcaggt cgggcggtac gacaggtcag agctgcggcc tgagcagcca     60
 gcgtccggca tgaaggtctg gggtctggct gctgcctgct tcttgctcca gcaccatgga    120
 atgcctgcgc agtttaccct gcctcctgcc ccgcgcgatg agacttcccc ggcggacgct    180
 gtgtgccctg gccttggacg tgacctctgt gggtcctccc gttgctgcct gcggccgccg    240
 agccaacctg attggaagga gccgagcggc gcagctttgc gggcccgacc ggctccgcgt    300
 ggcaggtgaa gtgcaccggt ttagaacctc tgacgtctct caagccactt tagccagtgt    360
 agccccagta tttactgtga caaaatttga caaacaggga aacgttactt cttttgaaag    420
 gaagaaaact gaattatacc aagagttagg tcttcaagcc agagatttga gatttcagca    480
 tgtaatgagt atcacagtca gaaacaatag gattatcatg agaatggagt atttgaaagc    540
 tgtgataact ccagagtgtc ttctgatatt agattatcgt aatttaaact taaagcaatg    600
 gctgttccgg gaactccctt cacagttgtc tggagagggt caactcgtta catacccttt    660
 accttttgag tttagagcta tagaagcact cctgcaatat tggatcaaca cccttcaggg    720
 gaaacttagc attttgcagc cactgatcct tgagaccttg gatgctttgg gggaccccaa    780
 acattcttct gtagacagaa gcaaactgca cattttacta cagaatggca aaagtctatc    840
 agagttagaa acagatatta aaattttcaa agagtcaatt ttggagatct tggatgagga    900
 agagttgcta gaagagctct gtgtatcaaa atggagtgac ccacaagtct ttgaaaagag    960
 cagtgctggg attgaccatg cagaagagat ggagttgctg ttggaaaact actaccgatt   1020
 ggctgacgat ctctccaatg cagctcgtga gcttagggtg ctgattgatg attcacaaag   1080
 tattattttc attaatctgg acagccaccg aaacgtgatg atgaggttga atctacagct   1140
 gaccatggga accttctctc tttcgctctt tggactaatg ggagttgctt ttggaatgaa   1200
 tttggaatct tcccttgaag aggaccatag aattttttgg ctgattacag gaattatgtt   1260
 catgggaagt ggcctcatct ggaggcgcct gctttcattc cttggacgac agctagaagc   1320
 tccattgcct cctatggtat gaaggatatg gttcacggcg gtattgtgga agggttatga   1380
 tcatgggccc taaagtcaga gcgcctggga ttaagttgtc acaggcacta tggcccttgc   1440
 gagttgcttt ctcaaacttc cttcagtttc cctatctgtc agttaagtcg gtattacctg   1500
 cttcataggg ttatgggaag aattaaacaa tatgtgtaaa gcacttacta gcccactgcc   1560
 taacccaata agttagaaat ataatttgtg tagaactctg acaacataca tttaaacaga   1620
 tgttagtaat tctggtataa ggtttgtcat aaccaaatgg aaatgtagga aacatttata   1680
 atgttcttaa aagatagaaa attcccctcc attttctttg tacttgaaga tggcaccact   1740
 ggaataaata cttaagacac tgaaaaaaaa cctcgtgcca agctggcgta agcaggtccg   1800
 agactatcag tgggatcagg nnccct                                        1826



      <210> 2392
      <211> 524
      <212> DNA
      <213> Homo sapiens


      <400> 2392
 ggaattcccg ggtcgacgat ttcgtggcgg ccggcggcgg cggaggcagc agtaaggcct     60
 cctcctcgtc ggcctcttcg gcaggggctc tggagtcctc gttggatcga aaattccagt    120
 cggtaaccaa caccatggag tccattcaag gcttgtcgtc ttggtgtata gagaacaaaa    180
 aacaccacag tactatcgtc tatcattgga tgaagtggct ccggagatct gcatatcccc    240
 accgtttgaa tctcttttac cttgccaatg atgtcataca gaactgtaaa aggaaaaatg    300
 caatcatatt ccgtgaatca tttgctgatg tacttcctga agcagctgct ctagtgaagg    360
 atccatctgt ctctaagtct gtagaacgaa tctttaaaat ctgggaagat agaaatgtat    420
 acccagaaga aatgattgtg gcattgagag aagctttgag taccactttc aaaactcaga    480
 agcagctgaa agaaaatctg aacaaacaac cgaataagca gtgc                     524



      <210> 2393
      <211> 1065
      <212> DNA
      <213> Homo sapiens


      <400> 2393
 gaatccctat gttaaacccg tggtttctca tgaattagat cataatttaa cattgtaaaa     60
 tttcagaaac tattgtgcta atatttagat ttcaggaagg aatcagacta aatcaattac    120
 ctccattcat tgttagaaca gaagatataa tagcttacta actgatatga gttatgaatg    180
 tcactatgac acaaaatttg ctgtgatttg ctaatctggc tacaagtgca gtatttttca    240
 tgaatgacaa cacacagcat ttccaacttg taacatgaaa ctccagctca taaagagtgt    300
 attgtgtgac ttgaaaaagt ctgattgtaa ctaagtaaca accgttcccc tgaaaaaacg    360
 aacaaaatcc attaggaaat caggcacaga cggtattgat cggtttttct tcctttcctc    420
 ctgtggtttt gtttctcaag acatataggt ggttccaaca gaagccaaca cttgttacaa    480
 aataacacag ctattttttt ccttttcttt ttctttatct ttttctcgtg gttccttccg    540
 tttacgttca ctattcccag attgtcttcc acttgatgga gaggcttgtg ctggctggcc    600
 ctgctgagcc tgtgtagaag cagcagcagc agcagctgct gcttgttcct gttcctgata    660
 gtattgagaa gcccgtctgt cctcttcctc ttggagtttc tttgctagtt ccaaatcact    720
 gattccttcc gggatttgtt cccaattgat ctcttggctc tgctgttctt gttgtagaga    780
 taatgccata agataatcct gatctatctg atcttgttgt cctttgtata cagtttcagg    840
 atctgaagga ggtcgaagat gaaattctga gtcacagaaa tttccatcac catctacgtt    900
 gtgtaggctt tcccaaacaa ctttctcttc agtaagaaac ccctggtccg ttaccaacaa    960
 atacagttga cccttgtatt tggtcatggt gctaaaatga ttattccgaa agaacacaca   1020
 aagttctcct tcctgaaccg ttgaagttag ttcacataat ccatg                   1065



      <210> 2394
      <211> 1917
      <212> DNA
      <213> Homo sapiens


      <400> 2394
 cgacccacgc gtccgcccac gcgtccggct cgcaagcgag gcagccatgt cttatcccgc     60
 tgatgattat gagtctgagg cggcttatga cccctacgct tatcccagcg actatgatat    120
 gcacacagga gatccaaagc aggaccttgc ttatgaacgt cagtatgaac agcaaaccta    180
 tcaggtgatc cctgaggtga tcaaaaactt catccagtat ttccacaaaa ctgtctcaga    240
 tttgattgac cagaaagtgt atgagctaca ggccagtcgt gtctccagtg atgtcattga    300
 ccagaaggtg tatgagatcc aggacatcta tgagaacagc tggaccaagc tgactgaaag    360
 attcttcaag aatacacctt ggcccgaggc tgaagccatt gctccacagg ttggcaatga    420
 tgctgtcttc ctgattttat acaaagaatt atactacagg cacatatatg ccaaagtcag    480
 tgggggacct tccttggagc agaggtttga atcctattac aactactgca atctcttcaa    540
 ctacattctt aatgccgatg gtcctgctcc ccttgaacta cccaaccagt ggctctggga    600
 tattatcgat gagttcatct accagtttca gtcattcagt cagtaccgct gtaagactgc    660
 caagaagtca gaggaggaga ttgactttct tcgttccaat cccaaaatct ggaatgttca    720
 tagtgtcctc aatgtccttc attccctggt agacaaatcc aacatcaacc gacagttgga    780
 ggtatacaca agcggaggtg accctgagag tgtggctggg gagtatgggc ggcactccct    840
 ctacaaaatg cttggttact tcagcctggt cgggcttctc cgcctgcact ccctgttagg    900
 agattactac caggccatca aggtgctgga gaacatcgaa ctgaacaaga agagtatgta    960
 ttcccgtgtg ccagagtgcc aggtcaccac atactattat gttgggtttg catatttgat   1020
 gatgcgtcgt taccaggatg ccatccgggt cttcgccaac atcctcctct acatccagag   1080
 gaccaagagc atgttccaga ggaccacgta caagtatgag atgattaaca agcagaatga   1140
 gcagatgcat gcgctgctgg ccattgccct cacgatgtac cccatgcgta ttgatgagag   1200
 cattcacctc cagctgcggg agaaatatgg ggacaagatg ttgcgcatgc agaaaggtga   1260
 cccacaagtc tatgaagaac ttttcagtta ctcctgcccc aagttcctgt cgcctgtagt   1320
 gcccaactat gataatgtgc accccaacta ccacaaagag cccttcctgc agcagctgaa   1380
 ggtgttttct gatgaagtac agcagcaggc ccagctttca accatccgca gcttcctgaa   1440
 gctctacacc accatgcctg tggccaagct ggctggcttc ctggacctca cagagcagga   1500
 gttccggatc cagcttcttg tcttcaaaca caagatgaag aacctcgtgt ggaccagcgg   1560
 tatctcagcc ctggatggtg aatttcagtc agcctcagag gttgacttct acattgataa   1620
 ggacatgatc cacatcgcgg acaccaaggt cgccaggcgt tatggggatt tcttcatccg   1680
 tcagatccac aaatttgagg agcttaatcg aaccctgaag aagatgggac agagaccttg   1740
 atgatattca cacacattca ggaacctgtt ttgatgtatt ataggcagga agtgtttttg   1800
 ctaccgtgaa acctttacct agatcagcca tcagcctgtc aactcagtta acaagttaag   1860
 gaccgaagtg tttcaagtgg atctcagtaa aggatctttg gagccacaaa aaaaaaa      1917



      <210> 2395
      <211> 3067
      <212> DNA
      <213> Homo sapiens


      <400> 2395
 tttttttttt ttgagatgga gtctcgctct gtcgcccagg ctggagtgca gtggtgcgat     60
 ctcggctcac tgcaagctcc gcctcccggg ttcacgccat tctcctgcct cagcctccca    120
 agtagctggg actacaggcg cccgccacca cgcccggcta attttttgta tttttagtag    180
 agacggggtt tcactgtgtt agccaggatg gtctcgatct cctgacctcg tgatccgccc    240
 gcctcggcct cccaaagtgc tgggattaca ggcgtgagcc accgcgcccg gctgcaaata    300
 atctttcttt ttttcttttt ttctgagaca gagtctcgct ctgttgccca ggctggagtg    360
 cagtggcggg atctcggctc acggcacgct ccgcctcccg ggttcacgcc attctcctgc    420
 ctcagcttcc cgagtagctg ggactacagg ggcccgccac cacgcccggc taattttttt    480
 gtatttttag tagagacggg gtttcaccgt tttagccggg atggtctcga tctcctgacc    540
 tcgtgatccg cccgcctcgg cctcccaaag tgctgggatt acaggcgtga gccaccgcgc    600
 ccggcctatt tttagtttta aacaaaaaag tttaagaagt aaaaaaaaaa catgttttgt    660
 tgtcgttttc tttgagaggg agtttagcat tgatgcccat gctggagtac aggggcatga    720
 tctcagttta ctgcatcatc ctgcctccga gttcaagaga tttctctgcc tcagcctcct    780
 gagtagctag gattacaggc tcctgccacc acaccccaca cattttttgt atttttagta    840
 gagaacggga attcgccatg ttggccaggc tggtcttgaa ctcctgatct caggtgatcc    900
 gcccgcctcg gcctccctaa gtgttgggac tacaggcgtg agccaccatg cctggcccca    960
 accagaacac ttctgagcgt ggaagaggat gctgttaatt actcaagacc aaaaggcata   1020
 aaaggagaca tatgtccacc caagtgataa ggcagtttgg gaaactacat ttcccagtat   1080
 gccctgcccc ttgaaagtta aaaatcttaa ctggcacaga gcaccctggg acacctgtgg   1140
 ttagcaccat ttaagaagta aaaggtatag ggttgggttc tgacgtgaag gctttcccct   1200
 tccatgggac acttaaccag acacaggaca caacacctga ggtgaaattt caatgggtat   1260
 taagtctggg gtagagcttc tctctcccca aatctagctt ccaaagatgt ggagctggtg   1320
 gagctgtcca ttggtccact gccctgtttc tcctgggtgc tgcctctgcc tcctcatatc   1380
 accagcgtcc ccactgccac tagtctgtag ggggattccg ggctaggtgc tcttcccact   1440
 cgacttcaac caacttatat agctccatgg tggcctgggc atcttccaca gaggaatgtc   1500
 cgctcttccc aacctggata tcccggttta gcagcttctt ggtgagatgc ttcagagaca   1560
 tggtggcatt ctccgggcag tcagccttcc ggttgagggg ggggatatgg gaggtgtcac   1620
 gggtgaggga cttggggtga aagtactgaa gggctttgaa gtcgttgtgg atggcatgcc   1680
 ccaccactat cttccctgtg agtatcttca agatctctcc atccttgaaa tgctcactcc   1740
 cacaagtttt ctttcttctg gaatccacct tcctcttcca caggtgattt ccatggtata   1800
 ccctgtttgg actcatactg ccagtggctc cttaccttct tattgatctc caccccatga   1860
 cattaatttg ccttcagtcc taaatgacac tcatgtttga gatgtccatg tatttagttc   1920
 agttctggct tgctacatga agtcctttaa ctattaccat tatgttggcc ttagacacat   1980
 ggctgggacc cgggctccag ggaggctaac aaaagcccaa aattacatgc aattagatgt   2040
 gtatgggtac tagaggaaga gaatctgtgg ctttcatcaa attctcagag tctacaaacc   2100
 gtaaaaaatt aagaatcaca tataaactaa agttgcagaa gcaaccttat tcacactagt   2160
 tttggaacca agtaaaataa aaataacttc tcaatatttc aggaaactgt tttttttttt   2220
 tgagatggag tctcgctctg tcgcccaggc tggagtgcag tggtgcgatc tcggctcact   2280
 gcaagctccg cctcccaggt tcacgccatt ctcctgcctc agcctcccaa gtagctggga   2340
 ctacaggcgc ctgccaccgc gcccggctaa ttttttgtat ttttagtaga gacggggttt   2400
 caccgtgtta gccaggatgg tttcgatctc ctgaccttgt gatccgcccg ccttggcctc   2460
 ccaaagtgct gggattacag gcatgagcca ccacgcccag gaaattattg tagttttagt   2520
 agagacaaga tttcaccatg ttggccaggc tggtctcaaa ctcctgactt caggtgatcc   2580
 gcctaccttg gcctccaaaa gtgctgggat tacaggcatg agctactgca cccggcctaa   2640
 ccaggctgga gtgcagtggt gggatctcgg ctcactgcaa gctccgcctc ccgggttctc   2700
 accattctcc tgcctcagcc tcccgagtag ctgggactac aggcgcccac caccacgccc   2760
 ggctaatttt ttgtattttt tagtagagac ggggtttcac catgttagcc aggatggtct   2820
 cgatctcctg acctcgtgat ccgcccgcct gggcctccca aagtgttggg attacaggcg   2880
 tgagccaccg cgcccggcca gcagcttcat ttattagggg cttcggtgag ggtggggaaa   2940
 ggcagcgcca gggtcagagg cgccgaaaga agagcttgga gccgtggtcc agcgtgcact   3000
 cgccggggcc cggccgactg ggctgcagct ggcgcagggc gtccctgtcc tcagcgcaga   3060
 ggcgtct                                                             3067



      <210> 2396
      <211> 6164
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> misc_feature
      <222> (1)...(6164)
      <223> n = a,t,c or g


      <400> 2396
 tttcgtgagt gtgagtgtga gtgggtgtgg gtgcgagccg ggccgccgac gatgccgcgg     60
 ggccgccccc cgaagcccag ggagagcaag gcgcgcggcg actccgatgg agttttaaca    120
 ttgaatgcgg agaacactaa ttatgcctat caagttccaa acttccataa atgtgaaatc    180
 tgtctactat cttttccaaa agaatcccag tttcaacgcc acatgaggga tcacgagcga    240
 aatgacaagc cacatcgatg tgaccagtgc ccccaaacat ttaatgttga attcaacctg    300
 acacttcata aatgcaccca cagcggggaa gatcctacct gccctgtgtg taacaagaaa    360
 ttctccagag tggctagtct caaagcgcat attatgctac atgaaaagga agagaatctc    420
 atctgttctg agtgtgggga tgagtttact ctgcagagtc agctggccgt gcacatggag    480
 gagcaccgcc aggagctggc tggaacccgg cagcatgcct gcaaggcctg caagaaagag    540
 ttcgagacct cctcggagct gaaggaacac atgaagactc attacaaaat tagggtatca    600
 agtacaaggt cttataaccg gaatatcgac agaagtggat tcacgtattc gtgtccgcac    660
 tgtggaaaga cgtttcaaaa gccaagccag ttaacgcgac acattaggat acacacaggt    720
 gaaaggccgt tcaaatgtag tgaatgtgga aaggctttta accagaaggg ggcgactgca    780
 gacccacatg atcaagcaca caggtgaaaa accccatgcc tgtgccttct gtcctgccgc    840
 cttctctcag aaagggaatc ttcagtcgca cgtgcagcga gtccactcag aggtcaagaa    900
 tggtcctacc tataactgta cagaatgtag ttgtgtattt aaaagtttag gcagcttaaa    960
 cacgcatatc agcaagatgc atatgggtgg gccacagaat tcaacaagtt ctacagagac   1020
 tgctcatgtt ttaacggcca cactttttca gacgttacct cttcaacaga cggaagccca   1080
 agccacgtcg gcctcaagcc agccgagctc ccaggcggtg agcgacgtca tccagcagct   1140
 cctggagctc tcagagccgg cgccggtgga gtcggggcag tccccgcagc ctgggcagca   1200
 gctgagcatc acagtgggca tcaaccagga cattttacag caagccttag aaaacagtgg   1260
 gctgttttca attccagctg cagcacatcc taatgactcc tgccatgcca agacctctgc   1320
 accacacgct caaaacccag atgtttccag cgtttcaaat gagcagacgg accccacaga   1380
 cgcagagcaa gaaaaagaac aggaaagccc ggagaaactg gataaaaaag aaaaaaaatg   1440
 ataaagaaga agtcaccgtt tctacctggc tccatccgcg aggagaacgg cgtgcgctgg   1500
 catgtgtgtc cctactgcgc caaggagttc cgcaagccca gcgacctggt ccgccacatc   1560
 cgcatccaca cccacgagaa gcccttcaag tgcccgcagt gcttccgcgc cttcgccgtg   1620
 aagagcacgc tgacagcgca catcaagacg cacaccggca tcaaggcgtt caagtgccag   1680
 tactgcatga agagcttctc cacctctggc agcctcaagg tgcacattcg cctgcacaca   1740
 ggagttagac cttttgcttg tcctcactgt gacaaaaaat ttcgaacctc aggccatagg   1800
 aagactcaca ttgcttccca ctttaaacat acggaattaa ggaaaatgag gcaccagcgt   1860
 aaacctgcaa aggtccgtgt tggcaagacg aatgttccag tccctgatat tcctttgcag   1920
 gaaccaatcc tcataactga cttaggtctc atccagccca ttccaaaaaa ccagtttttc   1980
 caaagctatt tcaataataa ttttgtcaat gaagcagata gaccatacaa gtgtttttac   2040
 tgtcatcgtg catataaaaa atcttgccac cttaaacaac acatcagatc ccatacaggt   2100
 gaaaaacctt ttaaatgttc tcagtgtgga agaggctttg tttctgcagg cgtgctcaaa   2160
 gcacacatca gaacacacac aggactgaaa tctttcaagt gtctgatatg taatggggct   2220
 ttcactactg gtggcagctt acggcgacac atgggtatcc acaacgacct tcgtccctat   2280
 atgtgtccct attgccaaaa aacatttaag acttcactaa attgcaaaaa gcacatgaaa   2340
 acccacagat atgagcttgc ccagcagctc caacagcatc agcaggcagc ctcgatagat   2400
 gacagcactg tagaccagca gagcatgcag gcctccactc aaatgcaggt ggagatcgag   2460
 agcgacgagc tgccgcagac ggcagaggtg gtcgcagcga accccgaggc catgctggac   2520
 ctggagcctc agcatgtggt gggcacggag gaagcagggc tgggccagca gttggcagat   2580
 cagcccctgg aagcagatga agatgggttt gtggctccac aggaccctct gcgagggcac   2640
 gtagaccagt ttgaagagca gagccctgcg caacagtcct tcgaaccagc agggctaccc   2700
 caaggtttta cagtgactga tacgtaccat cagcagcctc agtttccacc tgtccaacag   2760
 ctacaggatt ccagcacact tgagtctcag gccctctcca caagcttcca ccagcagagc   2820
 ttgctgcagg ctcctagctc tgatgggatg aatgtaacaa ctcgcttgat tcaggagtca   2880
 tcccaagagg aactggacct gcaggcacaa ggttcccagt ttctggagga caacgaggac   2940
 cagagcaggc gctcttacag gtgtgactat tgcaacaaag gctttaagaa gtccagccac   3000
 ctgaagcagc atgtgcggtc gcacaccggg gaaaagccct acaagtgcaa gctctgtgga   3060
 cgcggctttg tttcctctgg ggtcctcaag tcccacgaga agacacacac aggagtgaag   3120
 gcgttcagct gcagtgtgtg caatgcttcc ttcaccacca atggcagcct cacccggcac   3180
 atggccacac atatgagcat gaagccttat aagtgtccgt tttgtgagga gggtttccga   3240
 actacagtgc attgtaaaaa gcacatgaag agacaccaaa cagtcccctc tgctgtgtca   3300
 gccactggag agacagaagg aggagacatt tgtatggagg aagaggaaga acattctgac   3360
 agaaatgcat cacggaagtc tcgtcctgag gtcatcactt tcacggagga ggagacagcc   3420
 cagttagcca agatccggcc gcaggagagc gccacggtgt cagagaaggt cctggtgcag   3480
 tccgcggcag aaaaggaccg catcagtgag ctgagggaca agcaggcgga gctgcaggac   3540
 gagcccaagc acgccaactg ctgcacatac tgccccaaga gcttcaagaa acctagcgac   3600
 ctggtgaggc atgttcgaat ccatactgga gaaaagccat acaaatgtga tgaatgtgga   3660
 aagagtttta ctgtgaaatc cactctcgat tgtcatgtga agactcacac aggtcagaag   3720
 ctcttcagct gtcacgtctg cagcaacgcc ttctccacga agggaagtct gaaggtccac   3780
 atgcgcctgc acacgggagc caagcccttc aaatgcccgc attgcgagct gcgtttccgt   3840
 acctcgggta gaagaaagac acacatgcag tttcattata aaccagaccc aaagaaggcc   3900
 agaaagccta tgactcgaag ctcatcggaa ggactgcagc ctgtaaacct cctcaactcc   3960
 tcctctactg acccaaacgt gtttatcatg aacaactctg ttctaacagg acagtttgat   4020
 cagaatctgc tgcaaccagg actggtgggc caagctattc tccctgcctc tgtgtcagct   4080
 gggggtgacc tgaccgtgtc tctgacagat gggagcctgg ctaccctaga aggcatccag   4140
 ttacagttgg ctgctaactt ggttggacca aatgtacaga tttctggaat cgatgctgcc   4200
 agcattaata acattacgtt gcagattgat ccaagcattc tgcagcagac gctacagcag   4260
 ggcaacctat tggctcagca gctcacgggg gagcctggcc tggccccaca gaacagctct   4320
 ctccagacat cggacagcac ggtccctgcc agtgttgtca tccagcccat ctcaggcctg   4380
 tccttacagc ccacagtgac ctctgcgaac ctgaccatag gcccgctgtc tgagcaggat   4440
 tcagtgctga ccactaacag cagtgggacc caagacctca ctcaagtgat gacttcgcaa   4500
 ggtctagtgt ccccctccgg cggtccccac gagatcaccc tgaccattaa caactccagc   4560
 ctgagccagg tcctggcaca ggccgctggg cccactgcca cgtcttcctc ggggtctcca   4620
 caggaaatta ccctgactat ctccgaactt aacactacaa gcggaagcct tccttcaaca   4680
 acaccgacgt ctccatcggc catctcgact cagaacctgg tcatgtcctc gtcgggcgtg   4740
 ggaggtgacg ctagtgtcac gctgacgctg gccgatactc agggtatgct atctggaggc   4800
 ctggacactg tcacactcaa catcacctct cagggtcagc agttcccagc gctcctcacg   4860
 gatccctctc tctcgggcca gggtggagca ggctcgccgc aagtcatact agtgagccac   4920
 acgccacagt cagcgtctgc tgcttgtgaa gaaatagcct accaggtagc tggcgtctct   4980
 gggaacctgg ccccgggcaa ccagccagag aaggagggcc gggcgcacca gtgcctggag   5040
 tgtgaccgcg ccttctcatc ggcggcggtg ctcatgcacc acagcaagga ggtgcatggc   5100
 cgggagcgca tccacggctg ccccgtgtgc aggaaggcct tcaagcgcgc cacgcacctc   5160
 aaggagcaca tgcagacaca ccaggccggc ccctctttga gctcccagaa gccaagagtg   5220
 tttaaatgtg acacttgtga gaaggcattt gccaaaccaa gccagctgga gcgccacagc   5280
 cgcatacaca caggggagcg gccgttccat tgcacgcttt gtgagaaagc cttcaaccag   5340
 aagagtgcgc tgcaggtgca catgaagaag cacacggggg agcggcccta caagtgtgcc   5400
 tactgcgtca tgggcttcac gcagaagagc aacatgaagc tgcacatgaa gcgggcgcac   5460
 agctatgctg gagctctgca tgagtctgca ggtcacccgg agcaggacgg ggaggagctg   5520
 agccggaccc tccacctgga ggaggtggtg caggaggctg ccggcgagtg gcaggccctc   5580
 acccacgtct tctgatgcga gttggaagta cacctttaag aatgtttctg aagttacgtt   5640
 ttgtgaagag caaagcactt ggaatctctg ttttaaagct tcaagtgtta aaaatgctac   5700
 aatagttttt tatctataaa attatctaaa gaatcattgt ctttcagaga ctcataggaa   5760
 aaaaaaactg ggaaaagtgt caccgcattg ttctcttttg tctacaaatc actgaactca   5820
 ggtactactg tagggcagtt tcctcctcag tctcctccgt gggctagtgt gtctaggttc   5880
 acggagggca attaactggg gtcttactta tccattgtag gtgtggattt ctttgtatta   5940
 gcaaagacaa aaacgctaac atgggaaaaa gtatgtcagg attttccttc atgtttctgg   6000
 ttataagaag gcatagctta acaaaggcaa gcgtaaggat tggagggcat ggaagttcca   6060
 ggaaaaaaaa gtgttattaa cacacagggg gagttttttc cnctcttttn ctctgtggca   6120
 ttttggaaat tagtccaaat ggggnctctt ttccggtcta ccct                    6164



      <210> 2397
      <211> 4275
      <212> DNA
      <213> Homo sapiens


      <400> 2397
 ctgcagtgga tggtaaagtc acgggtcatt agcgagctac aggaggcctg ctgggacatg     60
 gtatctgcca tggcggcgac tgcggcaaag cgagagcctc ggagacgccg ctgccgccag    120
 cacagccgga gatctgagcc gacactgggg gcagtccgcg agccccgcac tctctcgatg    180
 agtcggagaa gtcccgttgt atcagagtaa gatggacggt agctttgatt gtgattgtgg    240
 tgagctggag ccacctgatc actaacaaaa gacatcttct gttaaccaac agccgccagg    300
 cttcctgttg aaataaatat atagcaacaa aggaaaaaaa gaagcaaaac ggaaatagtg    360
 cttaccagca ccttagaatg atgctgctca ggaccagtcc aacactgaat gtatctgcac    420
 tgtgaggaga atgttcatag aagcctgttg tgtgcatatt tattcacatt tttgttaaat    480
 gttaaatcgt ttagcacggt aatctgagtg cacagtatgt catttcattc cgtttgagtt    540
 tcttgttttc gttaaatgtc tgcagagttg ctgccccttt cttgaactat gagtactgca    600
 atctttttaa ttctcaatat gaatagagct ttttgagctt taaatctaag gggaactcga    660
 caggcctgtt tggcatatgc aatgaacatc aagaaaccat cttgctgtgg aagcataatt    720
 atttttcttc tccctttttg aaagatcttt ccttttgatg ccagttttct tccttgttta    780
 cacaagttca atttgaaagg aaaaggcaat agtaagggtt tcaaaatggc agagaaattt    840
 gaaagtctca tgaacattca tggttttgat ctgggttcta ggtatatgga cttaaaacca    900
 ttgggttgtg gaggcaatgg cttggttttt tctgctgtag acaatgactg tgacaaaaga    960
 gtagccatca agaaaattgt ccttactgat ccccagagtg tcaaacatgc tctacgtgaa   1020
 atcaaaatta ttagaagact tgaccatgat aacattgtga aagtgtttga gattcttggt   1080
 cccagtggaa gccaattaac agacgatgtg ggctctctta cggaactgaa cagtgtttac   1140
 attgttcagg agtacatgga gacagacttg gctaatgtgc tggagcaggg ccctttactg   1200
 gaagagcatg ccaggctttt catgtatcag ctgctacggg ggctcaagta tattcactct   1260
 gcaaatgtac tgcacagaga tctcaaacca gctaatcttt tcattaatac ggaagacttg   1320
 gtgctgaaga taggtgactt tggtcttgca cggatcatgg atcctcatta ttcccataag   1380
 ggtcatcttt ctgaaggatt ggttactaaa tggtacagat ctccacgtct tttactttct   1440
 cctaataatt atactaaagc cattgacatg tgggctgcag gctgcatctt tgctgaaatg   1500
 ctgactggta aaaccctttt tgcaggtgca catgaacttg aacagatgca gctgatttta   1560
 gaatctattc ctgttgtaca tgaggaagat cgtcaggagc ttctcagcgt aattccagtt   1620
 tacattagaa atgacatgac tgagccacac aaacctttaa ctcagctgct tccaggaatt   1680
 agtcgagaag cactggattt cctggaacaa attttgacat ttagccccat ggatcggtta   1740
 acagcagaag aagcactctc ccatccttac atgagcatat attcttttcc aatggatgag   1800
 ccaatttcaa gccatccttt tcatattgaa gatgaagttg atgatatttt gcttatggat   1860
 gaaactcaca gtcacattta taactgggaa aggtatcatg attgtcagtt ttcagagcat   1920
 gattggcctg tacataacaa ctttgatatt gatgaagttc agcttgatcc aagagctctg   1980
 tccgatgtca ctgatgaaga agaagtacaa gttgatcccc gaaaatattt ggatggagat   2040
 cgggaaaagt atctggagga tcctgctttt gataccaatt actctactga gccttgttgg   2100
 caatactcag atcatcatga aaacaaatat tgtgatctgg agtgtagcca tacttgtaac   2160
 tacaaaacga ggtcatcatc atatttagat aacttagttt ggagagagag tgaagttaac   2220
 cattactatg aacccaagct tattatagat ctttccaatt ggaaagaaca aagcaaagaa   2280
 aaatctgata agaaaggcaa atcaaaatgt gaaaggaatg gattggttaa agcccagata   2340
 gcgctagagg aagcatcaca gcaactggct ggaaaagaaa gggaaaagaa tcagggattt   2400
 gattttgatt cctttattgc aggaactatt catcttatgt tcccagcatg agcctactga   2460
 tgttggggag taaattaaat gacttgaata gctcagtgtc ccaactagaa ttgaaaagtt   2520
 tgatatcaaa gtcagtaagc caagaaaaac aggaaaaagg aatggcaaat ctggctcaat   2580
 tagaagcctt gtaccagtct tcttgggaca gccagtttgt gagtggtggg gaggactgtt   2640
 ttttcataaa tcagttttgt gaggtaagga aggatgaaca agttgagaag gaaaacactt   2700
 acactagtta cttggacaag ttctttagca ggaaagaaga tactgaaatg ctagaaactt   2760
 gagccagtag aggatgggaa gcttggggag agaggacatg aggaaggatt tctgaacaac   2820
 agtggggagt tcctctttaa caagcagctc gagtccatag gcatcccaca gtttcacagt   2880
 ccagttgggt caccacttaa gtcaatacag gccacattaa caccttctgc tatgaaatct   2940
 tcccctcaaa ttcctcatca gagcgataaa caggcagcat tctaaacaaa ctgaattaaa   3000
 acactcagca gacatttatc tttgtattct tcatgaaatg tgttttgtct ttttttttta   3060
 ttactagtgt ttaagtcatt ttttacttga atcagatggt gtcatttagt aaggatttta   3120
 tgagttcttg ttttttaaaa tccagacttt ctttttctac atgtgagata gttttcattt   3180
 taactggcat gtcatttgca cacaaaaata aagactagag caaaataatg caacgcagga   3240
 ggagaaaaga aatgcactaa gacaagaaca ttctctcata gaacattgat ctgttttaca   3300
 ggaaacaaac cttgccttga aatttacaca gtgagactgt acataattgc atgaaaatag   3360
 ctattttttt cctaagacat ttttcattca tgaatatttt caagtttttc atactgtaca   3420
 catttcttaa aacacatgat accagcagca actgaaaatg aatgccgaat ttggtacaca   3480
 tgtgttatct acctcaaggt aacaagagta tgtggcaaaa catataccac ccatagtgct   3540
 tcacaaaatg cacttctatt tagccagcgt ttattgtagt aaactattct taataaaact   3600
 cactcactgt ttataaatgt tctggtatgc attctttata gtgaagtgtt aatacatcac   3660
 atcttattta ttttagcaaa tcagtatatt ttctgtattt aattataaaa aattaactta   3720
 gtttttaaaa tttatttgca aatatacttt ttccatttgg cactatggtt tgttgcctac   3780
 ctagctgcat ctataatgtc agcttatcct aaggctgtcc acgtacttaa tttacttaag   3840
 tgttcatttt aagtaacgtg ctcactgtgt ataggaattt gtattttgga ggtgcttgat   3900
 ctatctacaa aagaaaaaat taattaggaa ttactttatt ataaaatgct cctagaagtc   3960
 ttaattgtgt ttatttttta aaaaaacaaa tgttagactt gtgtgcatgg aagtaattaa   4020
 ggtacatcat tattgtagtt tgaaagttgt acatgataag acattttgtt tttactgtat   4080
 gtttttactg aatgatctat tccccatccc aaggcaagca tgaataaaat taggttaaac   4140
 gtagcatgtg gcatcgcagt ctcttagaat ttgtttcatc tattttattt tattgaatac   4200
 tgtctgtatc tttggttatc ctgtttgaag aaaaaggaca aataaaacat ggccagcaaa   4260
 tacaaaaaaa aaaaa                                                    4275



      <210> 2398
      <211> 828
      <212> DNA
      <213> Homo sapiens


      <400> 2398
 gtcgacccac gcgtccgcag acagaatctt ggatttgggt tttgaaaagg acatcacagt     60
 gatacttaat gctgtaaatg ctgaatgcca aaaacgacag aatgtcttgc tatcagcgac    120
 actcacagaa ggtgtaacgc ggctagctga tatcagtttg catgatccag tcagtatttc    180
 tgtcctggac aagagccatg accagttgaa cccaaaggac aaagcggtcc aggaggtctg    240
 tcctccacca gctggcgaca agctggacag ctttgcaata ccagagagtc tcaagcagca    300
 tgtgactgtg gttcccagca aactgaggct tgtctgccta gcggccttca tccttcagaa    360
 atgcaagttt gaggaagacc agaagatggt tgtctttttc tcaagttgcg agctggtgga    420
 gttccactac agcctcttcc tacagaccct gctgagcagc tcaggggcgc cggcatcagg    480
 gcagttgcca tctgcctcca tgcgattaaa attcctacgg ctgcatggcg gcatggagca    540
 ggaggaaaga acagcagtgt ttcaggaatt ttcacattcc agaagaggcg tccttctttg    600
 cacggatgtt gcagctcggg gcttagatct ccctcaagtc acgtggattg ttcagaatac    660
 atccaccgga ttggaagaac cgcccggatt ggctgccatg ggagcagcct gctcattttg    720
 gctccttcgg aggcagaata tgtcaactcg ttggcttctc acaaaatcaa cgtttctgag    780
 attaagatgg aagatatttt gtgtgttctg acaagagatg attggttt                 828



      <210> 2399
      <211> 574
      <212> DNA
      <213> Homo sapiens


      <400> 2399
 caaaatgtgg ctggaatcag gagaccggag agaccaatga ggggaacagg acgattgtat     60
 ttaggtggcc accagctcag cagattaata cccagaggct gagcaatgag caaagaaagg    120
 gcttgacttt tattcatgtg accaaagggt gttggccggg ccttagctgc cttcccgcgg    180
 ggcagggctc gggacctgca gcccgccatg cctgagcctc ccacccactc catgggctcc    240
 tgtgcggtcc gagcctcccc gacgagcacc accccctgct ccacggtgcc cagtcccatc    300
 aaccacccaa gggctgagga atgcgagcgc atggcacggg actggcaggc agctccacct    360
 gcagccccag tgcgggatcc actaggtgaa gccagctggg ctcctgagtt ctttgggtcc    420
 atgctgcctt tatgagctgt aacatttatc gcgaagatct gcagcttcac tcctgagccc    480
 agcgagacca caagcccacc aggaggaacg aacaactcca gacacgctgc tttaagagct    540
 gtaacactaa ccgcgaaggt ctgcagcttc actc                                574



      <210> 2400
      <211> 4629
      <212> DNA
      <213> Homo sapiens


      <400> 2400
 atgcggaaag acagacttct tcatttatgt cttgtgctac ttcttatcct gctttctgcc     60
 agtgactcaa actctacaga accgcagtat atggtgctgg tcccctccct gctccacact    120
 gaggccccta agaagggctg tgtccttctg agccacctga atgagacagt gactgtaagt    180
 gcttccttgg agtctggcag ggaaaacagg agcctcttca ctgacctggt ggcggagaag    240
 gacttattcc actgtgtctc cttcactctc ccaaggatct cagcctcttc agaggtggca    300
 ttccttagca tccagataaa ggggcctacg caagatttca ggaagaggaa cacagttctg    360
 gtactgaaca cccaaagtct ggtctttgtc cagacagaca aacccatgta taaaccagga    420
 cagacagcct cctgtcttat tacccaaatt acctgcttta tcatgtctga atcttatcgg    480
 agaactactt ttccagtaag attccgtgtt gtctccgtgg atgaaaattt tcgccctcga    540
 aatgaactga acccaagaag aaatcgaatt gcacaatggc agagtctcaa gctagaagct    600
 ggcatcaatc agttgtcctt tcccctctca tcagagccca ttcagggctc ctacagggtg    660
 gtggtacaga cagaatcagg tggaaggata cagcacccct tcaccgtgga ggaatttgtg    720
 cttcccaagt ttgaggtcaa agttcaggtg ccaaagataa tcagtatcat ggatgaaaaa    780
 gtgaacataa cagtctgtgg agaatacact tatgggaagc ctgtcccagg acttgcaact    840
 gtgagcctgt gtagaaaatt atctcgtgtt cttaattgtg acaagcagga ggtctgtgag    900
 gaattcagtc aacagcttaa cagcaatggc tgcatcaccc aacaagtaca caccaaaatg    960
 ctccagatta caaatacggg ctttgaaatg aagcttagag tggaagccag gatcagagaa   1020
 gaggggacag acctggaagt cactgcaaac aggatcagtg aaatcacaaa cattgtatcc   1080
 aaactcaaat tcgtgaaagt ggattcacac tttagacaag gaatcccctt ttttgcacag   1140
 gtgcttctgg tggatggaaa aggtgtgccc atccccaata aactcttctt catctctgtg   1200
 aatgacgcca attattactc caatgcaacc accaatgagc agggtcttgc acagttttca   1260
 atcaatacta ccagtatctc ggttaataaa ctttttgtcc gggttttcac tgtgcatccc   1320
 aacttgtgtt ttcactattc atgggtagca gaagaccacc agggtgctca gcacactgca   1380
 aatcgtgttt tctccttaag tggaagttac attcacctgg agcctgtggc tggtaccctg   1440
 ccctgtggcc acacggagac tatcacggca cactatacac tgaatagaca ggccatggga   1500
 gagttatcgg agctcagttt ccattacctg atcatggcta agggagtcat cgtcagatct   1560
 ggaacccaca ctctgcctgt ggagtcagga gacagcattc atagcaatga tcatggcagt   1620
 atgactcagg ggattggggg atccccacta gcaactgtgc atgcatttgc actgacggtg   1680
 gtgttagcat gggggtgggg cactgtgaaa ggcagttttg ccttatcctt ccctgtggag   1740
 tcagacgttg cccccattgc acgaatgttc atctttgcca ttttaccaga tggagaagtt   1800
 gttggagact ctgaaaaatt tgagattgaa aactgtctag ccaacaaggt ggatttgagc   1860
 ttcagcccag cacaaagtcc cccagcctca catgcccacc tgcaagtagc agctgctccg   1920
 cagtccctct gtgcccttcg tgctgtggac caaagtgtgc tgctcatgaa gcctgaggct   1980
 gagctctctg tgtcctcagt atataatctg ctaactgtga aggatctcac caattttcct   2040
 gacaatgtgg accagcagga ggaagaacaa ggacactgtc cccgtccttt cttcattcat   2100
 aatggagcca tctatgttcc cttatcaagt aatgaagcag atatttatag cttcctcaag   2160
 gggatgggat tgaaggtgtt cactaactca aaaatccgaa aaccaaagtc gtgttcagtc   2220
 atcccttccg tgtctgcagg agcagtaggt caaggatact atggaggtct aggagtagta   2280
 gagagaccat atgttcctca attaggcaca tataatgtga tacccttaaa taatgaacaa   2340
 agttcagggc cagtccctga aacggtgcga agctattttc ctgagacttg gatctgggag   2400
 ttggtggcag tgaactcatc aggtgtggct gaggtaggag taacagtccc tgacaccatc   2460
 accgagtgga aggcaggggc cttctgcctg tccgaagatg ctggacttgg tatctcttcc   2520
 actgcctctc tccgagcctt ccagcccttc tttgtggagc tcacaatgcc ttactctgtg   2580
 attcgtggag aggtcttcac actcaaggcc acggtcctaa actaccttcc caaatgcatc   2640
 cgggtaagga aaatgagggt gaacaggaaa gggaatgtga acttctcagt gagtgcagag   2700
 gcaatgcagt ccttagaact ctgtggaaat gaggttgttg aggtccctga gattaaaaga   2760
 aaagacacag tcatcaaaac cctgttggtg gaggctgaag gtattgagca agaaaagact   2820
 ttcagttcta tgacctgtgc ctcaggtgct aatgtgtctg agcagttgtc cttgaagctc   2880
 ccatcaaatg tggtcaaaga atctgccaga gcttctttct cagttctggg tgacatatta   2940
 ggttctgcta tgcaaaatat acaaaatctc ctccagatgc catatggctg tggagaacag   3000
 aacatggtcc tatttgctcc taacatctat gtcttgaact atctgaatga aacccagcag   3060
 ctgacgcagg agatcaaggc caaggccgtt ggctatctca tcactggtta ccagagacag   3120
 ctgaactaca aacaccaaga tggctcctac agcacctttg gggaacgata tggcaggaac   3180
 cagggcaaca cttggctcac agcttttgta ctgaagactt tcgcccaggc tcgatcctac   3240
 atcttcattg atgaagcaca cattacccaa tctctcacgt ggctctccca gatgcagaag   3300
 gacaatggct gtttcaggag ctctgggtca ctgctcaaca atgccataaa gggaggtgta   3360
 gaagatgaag cgaccctctc cgcctatgtt actattgccc ttctggaaat tcctctccca   3420
 gtcactaacc ctattgttcg caatgccctg ttctgcctgg agtcagcctg gaatgtagca   3480
 aaggagggga cccatgggag ccatgtctac accaaggcat tgctggccta tgctttttcc   3540
 ctactgggaa agcaaaatca gaatagagaa atactgaact cacttgataa ggaagctgtg   3600
 aaagaagatc cagagatgga ggaaggactg tgcctggagg tggaggggaa gatggtcagt   3660
 aggacaaagg gtgacattga tgactcgctt attggtggag atgccttcac tgaagtttcc   3720
 caaagcgaag acaacctcgt ccattgggag cgccctcaga gacccaaggc accagtgggg   3780
 catctttacc aaacccaggc tccctctgct gaggtggaga tgacatccta tgtgctcctc   3840
 gcttatctca cggcccagcc agcccccacc tcaggggacc tgacctctgc aactaacatt   3900
 gtgaagtgga tcatgaagca gcagaacgcc caaggtggtt tctcctccac ccaggacaca   3960
 gtggtggctc tccatgccct gtccaggtat ggagcagcca ctttcaccag aactgagaaa   4020
 actgcacagg tcaccgttca ggattcacag accttttcta caaatttcca agtagacaac   4080
 aacaacctcc tattactgca gcagatctca ttgccagagc tccctggaga atatgtcata   4140
 acagtaactg gggaaagatg tgtgtatctt cagacatcca tgaaatacaa tattcttcca   4200
 gagaaagagg actccccatt tgctttaaaa gtgcagactg tgccccaaac ttgcgatgga   4260
 cacaaagccc acaccagctt tcagatctca ctgaccatca gttacacagg aaaccgtcct   4320
 gcttccaata tggtgattgt tgatgtaaag atggtatctg gttttattcc cctgaaacca   4380
 acagtaaaaa tgcttgaaag atctagctct gtgagccgga cagaagtgag caacaaccat   4440
 gtcctcattt atgtggaaca ggtgacaaat cagacgctaa gtttttcctt catggttctg   4500
 caagacatcc cagtaggaga cttgaagcca gcaattgtta aagtctatga ttactatgag   4560
 acagatgagt ctgtggttgc tgagtatatc gccccctgca gcacagatac agagcatgga   4620
 aatgtttga                                                           4629



      <210> 2401
      <211> 1525
      <212> DNA
      <213> Homo sapiens


      <400> 2401
 ttcttttcat ctgctttagg aaagctcagt aagctttctt ttttttccag aggcagggtc     60
 tggctgtatc acccaggctg gagtgtatgg cacaaccatt gctcactgcg gcctcaacct    120
 cctgggctca agtgatcctc ccgcctcagg ctcccaaagt gctgggatag caggcatgag    180
 ctgtcgcacc tagccagcaa tatacaacct tgaagggtta atagtgacat ggacagaggc    240
 aaggtgccca gttacacatt ttcagacatc atcttgttta ttacaaaact taaaacacct    300
 tccaggcaag atccaaagca attttatcct aacattgttc accttcatct gtagagtcaa    360
 atgtatctgc cagcttgtgt tgacaagggg gaatgcttcc catttggtca aggttgaggg    420
 acagtaaagg aatcttgtat tctaatgagt acagcatcct ttcattgtcc aagccatcca    480
 ccttagggct ttgaggttca agtccaggtc tggagaagag aaagtttcat acccaacctt    540
 gtggtctttc cttcggtagt acattcgtgt cagcacagtc attagaaaag tctccagtat    600
 gaggaggtgg caattcatca cttgagacct ggttttagag gaatagggag gcgaacaagc    660
 aatctgccca ccgttggcca agactgagaa gatggagggc tgtagggcag tcaggatgag    720
 gagaacctgg aacagagcaa atttggctcc catgttctgc tcacccaggt gtagcctggc    780
 ttgacgggaa atgatgccca gggtccagag agccagcagt gtggacacgc cgaggaaagt    840
 gttgatccat agagctgtgc tcccctcaga aatgtctgct gggtcataga tgccgtcggg    900
 gatgagaaac aggcccacca gggtcagcgt tatcttcaag aaggcgtatt ggaaagggcc    960
 caacatcagc agctgaagct tcttcctggt gagcagcagc cgtggacagc aggggcagca   1020
 gcagcagcag gggcctgtgt ggaccatcat cggggtgtcc ctcagcgtcc tcagcactgc   1080
 ctccttcccc ccaaagcctt ccaccatgac cagcatcagc aggtaaaagc acacggcata   1140
 aaacgaggtg atggtcattt ccaccagcac cagggaacga gggatccaga gaccaaagca   1200
 gcacagcaca gacaccaccg tgggtgccga gctcttccag agcagagtcc gcctcttgat   1260
 ggggcaaagg gtgttcttgt acaggtagac ggcatcctcc aggaagatgg caatggagcc   1320
 cagcgccagc aaggtcagga tgctagtgag ggcaagttcc acagggccca gggctctcag   1380
 gagttgggct gctgtgggag gctgagagaa gcaggcggag gggatgccgt aattggtctt   1440
 cagcacctcc agaagatctg ctgtgtacct ggggtcaagc tttatctggg tcctgcccgg   1500
 ctccatcgcc gcgaattccg ccacg                                         1525



      <210> 2402
      <211> 1621
      <212> DNA
      <213> Homo sapiens


      <400> 2402
 ttttttagaa cgaactttat ccatagtagc agtgtacatt cccactagca acttaggaga     60
 gtttcagtta ctctactcca catccttcca acagttgata tcaccagtgt aactgcataa    120
 gtaatgttaa tttaaagata cagcaaatgt ttttgtttct ttatttcaga tgagaaataa    180
 ctttagacat tatttcattg aaccttccca actgaaatta ttttatgatg ttataacatg    240
 gatagtaact caagtagcaa taagttacac agttgtgcca tttgtgcttc tttctataaa    300
 accatcactc acgttttaca gctcctggta ttattgcctg cacattcttg gtatcttagt    360
 attattgttg ttgccagtga aaaaaactca aagaagaaag aatacacatg aaaacattca    420
 gctctcacaa tccaaaaagt ttgatgaagg agaaaattct ttgggacaga acagtttttc    480
 tacaacaaac aatgtttgca atcagaatca agaaatagcc tcgagacatt catcactaaa    540
 gcagtgatcg ggaaggctct gagggctgtt tttttttttt tggaggtaaa caaaaaccaa    600
 tcttaggcac cttttcaagg gggttgagtt tgttgggaaa aggcagttta actgggggga    660
 aatggacagt tatagataag gaatttcctg ttacaccaga ttggaaatgg agtgaaacaa    720
 gccctcccat gccatgtccc cgtgggccac gccttatgta agaatatttc catatttcag    780
 tgggcactcc caacctcagc acttgtccgt agggtcacac gcgtgccctg ttgctgaatg    840
 tatgttgcgt atcccaaggc actgaagagg tggaaaaata atcgtgtcaa tctggatgat    900
 agagagaaat taacttttcc aaatgaatgt cttgccttaa accctctatt tcctaaaata    960
 ttgttcctaa atggtatttt caagtgtaat attgtgagaa cgctactgca gtagttgatg   1020
 ttgtgtgctg taaaggattt taggaggaat ttgaaacagg atatttaaga gtgtggatat   1080
 ttttaaaatg caataaacat ctcagtattt gaagggtttt cttaaagtat gtcaaatgac   1140
 tacaatccat agtgaaactg taaacagtaa tggacgccaa attataggta gctgattttg   1200
 ctggagagtt taattacctt gtgcagtcaa agagcgcttc cagaaggaat ctcttaaaac   1260
 ataatgagag gtttggtaat gtgatatttt aagcttattc tttttcttaa aagagagagg   1320
 tgacgaagga aggcaggaat gaagaagcac tgcgtggcct ccggtggaat gcacggggca   1380
 cagccgcgac tctgcaggca gcttcccccc catgccaggg ctctgcgccg tcatgtgaga   1440
 cttaaaaaaa aagttgaatg acttcgtgat actttggact tctaaattaa atttatcagg   1500
 cataaattat gtagaattag aggctttgaa aataatactg gtaggttgct caaaggtttt   1560
 gaaagagaaa tcgctaggta ggttactatc tggctaatcc atttcttatc cttgacaatt   1620
 a                                                                   1621



      <210> 2403
      <211> 340
      <212> DNA
      <213> Homo sapiens


      <400> 2403
 aatgacgggc cagctgccaa cagcatctcc gtcaggaccc ccaccaaggg ccccaacgac     60
 caccgggtcg ttcaaaccca cagccgccaa tccagcctcc gccactaggg gcaccactgc    120
 tgcggtcagt acagaccgct acaaccacaa atgccgcaac cacgaccccg tctaggatca    180
 gatacacagc cggggaggcc agcaccgccc cccaacacaa ggcaatggcg ggtgctacag    240
 ccagcgccac cagcagcagt gccgccgccg cagccactac tccagccccc agcgcgcctg    300
 ccaccaaagc cacgccaagc atggccgcag tcgcccccgc                          340



      <210> 2404
      <211> 373
      <212> DNA
      <213> Homo sapiens


      <400> 2404
 cggcacgagg ccattgttcc ctctgccctg aacatgcgtg gtcaacccct tcctgtctca     60
 tgtcaccctt cagcgaggcc ttcccgctaa gctggtccat ctgatctaca atggcagccc    120
 aagagctatt tcccacaccc tccttttcca cttctctgct taacacgggt acactataag    180
 gtgtctttct tgctcagttg atggtttcac ctgctgttgc ctggtttgta agccccataa    240
 gaggaagacc agagatcttg gtcattgctg taccctcacc attcatagca gtccctgtac    300
 ctctgtaggt acttaaggga caccttttaa aagaagggtg agaggaaggg caagggagac    360
 agggaggaaa agg                                                       373



      <210> 2405
      <211> 3261
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> misc_feature
      <222> (1)...(3261)
      <223> n = a,t,c or g


      <400> 2405
 gcgtgcaagt ccctgcctgt aacggcggcg gcggctgctg ctccagacac ctgcggcggc     60
 ggcggcgttc ccgcggcggg cgcggagatg tggcccctgg tagcggcgct gttgctgggc    120
 tcggcgtgct gcggatcagc tcagctacta tttaataaaa caaaatctgt agaattcacg    180
 ttttgtaatg acactgtcgt cattccatgc tttgttacta atatggaggc acaaaacact    240
 actgaagtat acgtaaagtg gaaatttaaa ggaagagata tttacacctt tgatggagct    300
 ctaaacaagt ccactgtccc cactgacttt agtagtgcaa aaattgaagt ctcacaatta    360
 ctaaaaggag atgcctcttt gaagatggat aagagtgatg ctgtctcaca cacaggaaac    420
 tacacttgtg aagtaacaga attaaccaga gaaggtgaaa cgatcatcga gctaaaatat    480
 cgtgttgttt catggttttc tccaaatgaa aatattctta ttgttatttt cccaattttt    540
 gctatactcc tgttctgggg acagtttggt attaaaacac ttaaatatag atccggtggt    600
 atggatgaga aaacaattgc tttacttgtt gctggactag tgatcactgt cattgtcatt    660
 gttggagcca ttcttttcgt cccaggtgaa tattcattaa agaatgctac tggccttggt    720
 ttaattgtga cttctacagg gatattaata ttacttcact actatgtgtt tagtacagcg    780
 attggattaa cctccttcgt cattgccata ttggttattc aggtgatagc ctatatcctc    840
 gctgtggttg gactgagtct ctgtattgcg gcgtgtatac caatgcatgg ccctcttctg    900
 atttcaggtt tgagtatctt agctctagca caattacttg gactagttta tatgaaattt    960
 gtggcttcca atcagaagac tatacaacct cctaggaaag ctgtagagga accccttaat   1020
 gaataactga agtgaagtga tggactccga tttggagagt agtaagacgt gaaaggaata   1080
 cacttgtgtt taagcaccat ggccttgatg attcactgtt ggggagaaga aacaagaaaa   1140
 gtaactggtt gtcacctatg agacccttac gtgattgtta gttaagtttt tattcaaagc   1200
 agctgtaatt tagttaataa aataattatg atctatgttg tttgcccaat tgagatccag   1260
 ttttttgttg ttatttttaa tcaattaggg gcaatagtag aatggacaat ttccaagaat   1320
 gatgcctttc aggtcctagg gcctctggcc tctaggtaac cagtttaaat tggttcaggg   1380
 tgataactac ttagcactgc cctggtgatt acccagagat atctatgaaa accagtggct   1440
 tccatcaaac ctttgccaac tcaggttcac agcagctttg ggcagttatg gcagtatggc   1500
 attagctgag aggtgtctgc cacttctggg tcaatggaat aataaattaa gtacaggcag   1560
 gaatttggtt gggagcatct tgtatgatct ccgtatgatg tgatattgat ggagatagtg   1620
 gtcctcattc ttgggggttg ccattcccac attccccctt caacaaacag tgtaacaggt   1680
 ccttcccaga tttagggtac ttttattgat ggatatgttt tccttttatt cacataaccc   1740
 cttgaaaccc tgtcttgtcc tcctgttatt tgcttctgct gtacaagatg tagcaccttt   1800
 tctcctcttt gaacatggtc tagtgacacg gtagcaccag ttgcaggaag gagccagact   1860
 tgttctcaga gcactgtgtt cacacttttc agcaaaaata gctatggttg tgacatatgt   1920
 attcccttcc tctgatttga aggcaaaaat ctacagtgtt tcttcacttc ttttctgatc   1980
 tggggcatga aaaaagcaag attgaaattt gaactatgag tctcctgcat ggcaacaaaa   2040
 tgtgtgtcac catcaggcca acaggccagc ccttgaatgg ggatttatta ctgttgtatc   2100
 tatgttgcat gataaacatt catcaccttc ctcctgtagt cctgcctcgt actccccttc   2160
 ccctatgatt gaaaagtaaa caaaacccac atttcctatc ctggttagaa gaaaattaat   2220
 gttctgacag ttgtgatcgc ctggagtact tttagacttt tagcattcgt tttttacctg   2280
 tttgtggatg tgtgtttgta tgtgcatacg tatgagatag gcacatgcat cttctgtatg   2340
 gacaaaggtg gggtacctac aggagagcaa aggttaattt tgtgctttta gtaaaaacat   2400
 ttaaatacaa agttctttat tgggtggaat tatatttgat gcaaatattt gatcacttaa   2460
 aacttttaaa acttctaggt aatttgccac gctttttgac tgctcaccaa taccctgtaa   2520
 aaatacgtaa ttcttcctgt ttgtgtaata agatattcat atttgtagtt gcattaataa   2580
 tagttatttc ttagtccatc agatgttccc gtgtgcctct tttatgccaa attgattgtc   2640
 atatttcatg ttgggaccaa gtagtttgcc catggcaaac ctaaatttat gacctgctga   2700
 ggcctctcag aaaactgagc atactagcaa gacagctctt cttgnnnnnn nnnntatgta   2760
 tacacaaata tatacgtata tctatatata cgtatgtata tacacacatg tatattcttc   2820
 cttgattgtg tagctgtcca aaataataac atatatagag ggagctgtat tcctttatac   2880
 aaatctgatg gctcctgcag cactttttcc ttctgaaaat atttacattt tgctaaccta   2940
 gtttgttact ttaaaaatca gttttgatga aaggagggaa aagcagatgg acttgaaaaa   3000
 gatccaagct cctattagaa aaggtatgaa aatctttata gtaaaatttt ttataaacta   3060
 aagttgtacc ttttaatatg tagtaaactc tcatttattt ggggttcgct cttggatctc   3120
 atccatccat tgtgttctct ttaatgctgc ctgccttttg aggcattcac tgccctagac   3180
 aatgccacca gagatagtgg gggaaatgcc agatgaaacc aactcttgct ctcactagtt   3240
 gtcagcttct tgggtaagtg g                                             3261



      <210> 2406
      <211> 2981
      <212> DNA
      <213> Homo sapiens


      <400> 2406
 atggagcccg ccggcccggc ccccggccgc ctcgggccgg tgctctgcct gctgctcgcc     60
 gcgtcctgcg cctggtcagc ttccaggcag ctccctgcag ttcaggtgct ccgcggggat    120
 gttacctgtg gctctgacca tgtctttctg ttggcctaca tcaaacacct ggctgtcgcc    180
 ggcaggcggg ctctgaaggc tactgtgcat gttcaccaaa ggacccttct ccgaccagga    240
 ggctgtggtt cagtccctgg caaacgagca gtgacgctga ttagcaagtg ctccgatggg    300
 cagcctgcct ttcctggggc accggctggg aacaccaaca cctttcttgt ctgcagttgt    360
 ggattcccgg acctgcaaag cagtaggggg cctgagagag ccctctgtgc tttcatccag    420
 tgccttatgg tgcggccaga agaacagaga gaaaaaaact ggccgggccc acgcgggaga    480
 tccatggcaa ggcccggctg gaacgccaag cctcctgtgg tccaggccaa ggcttttaaa    540
 aactgggctg tgctggaact ttccactgtt tcagccagaa atctgacagg atcccgaatt    600
 ccccgggaaa acactaaagt aatactaata ggaaccatct gggttctctg cttcctgggc    660
 tcagcacttg gtgtgtgtga ccctggtggt actcacagcc acctggcgat gcacgtcgtt    720
 atcttcggac ccgttggatc taacaaccct agtattgtta tcatcatcat catcatcaga    780
 cccattctac agataaagag ccagaggtcc agagtgggcg agacattccc tggagtctca    840
 tgggtagcag agttggaatc caaatcaaaa catactttca gccagtgcca ggcactgctc    900
 caaccctggg gaagaaaact cagttcctgc tctcaaagga cttataacct gcttctggtg    960
 tgcatccagt caatgaacgt cattgataaa cacttgagga aacacagagg atcacgagtg   1020
 gcgggtgagg aggagctgca ggtgattcag cctgacaagt ccgtgttggt tgcagctgga   1080
 gagacagcca ctctgcgctg cactgcgacc tctctgatcc ctgtggggcc catccagtgg   1140
 ttcagaggag ctggaccagg ccgggaatta atctacaatc aaaaagaagg ccacttcccc   1200
 cgggtaacaa ctgtttcaga cctcacaaag agaaacaaca tggacttttc catccgcatc   1260
 ggtaacatca ccccagcaga tgccggcacc tactactgtg tgaagttccg gaaagggagc   1320
 cccgatgacg tggagtttaa gtctggagca ggcactgagc tgtctgtgcg cgccaaaccc   1380
 tctgcccccg tggtatcggg ccctgcggcg agggccacac ctcagcacac agtgagcttc   1440
 acctgcgagt cccacggctt ctcacccaga gacatcaccc tgaaatggtt caaaaatggg   1500
 aatgagctct cagacttcca gaccaacgtg gaccccgtag gaggagagcg tgtcctacag   1560
 catccacaag cacagccaag gtggtgctga acccgcgagg acgtcaactc tcagtcattc   1620
 tggtaggggc ccacagtcac cttgcagggg gaccctcttc gtgggactgc caacttgtct   1680
 gagaccatcc gagttccacc caccttggag gttattcaac agcccgtgag ggcagagaac   1740
 caggtgaatg tcacctgcca ggtgaggaag ttctaccccc agagactaca gctgacctgg   1800
 ttggagaatg gaaacgtgtc ccggacagaa acggcttcaa ccgttacaga gaacaaggat   1860
 ggtacctaca actggatgag ctggctcctg gtgaatgtat ctgcccacag ggatgatgtg   1920
 aagctcacct gccaggtgga gcatgacggg cagccagcgg tcagcaaaag ccatgacctg   1980
 aaggtctcag cccacccgaa ggagcagggc tcaaataccg ccgctgagaa cactggatct   2040
 aatgaacgga acatctatat tgtggtgggt gtggtgtgca ccttgctggt ggccctactg   2100
 atggcggccc tctacctcgt ccgaatcaga cagaagaaag cccagggctc cacttcttct   2160
 acaaggttgc atgagcccga gaagaatgcc agagaaataa cacaggacac aaatgatatc   2220
 acatatgcag acctgaacct gcccaagggg aagaagcctg ctccccaggc tgcggagccc   2280
 aacaaccaca cggagtatgc cagcattcag accagcccgc agcccgcgtc ggaggacacc   2340
 ctcacctatg ctgacctgga catggtccac ctcaaccgga cccccaagca gccggccccc   2400
 aagcctgagc cgtccttctc agagtacgcc agcgtccagg tcccgaagaa gtgaatggga   2460
 ccgtggtttg ctctagcacc catctctacg cgctttcttg tcccacaggg agccgccgtg   2520
 atgagcacag ccaacccagt tcccggaggg ctggggcggt gcaggctctg ggacccaggg   2580
 gccagggtgg ctcttctctc cccacccctc cttggctctc cagcacttcc tgggcagcca   2640
 cggccccctc cccccacatt gccacatact tggaggctga cgttgccaaa ccagccaggg   2700
 aaccaacctg ggaagtggcc agaactgcct ggggtccaag aactcttgtg cctccgtcca   2760
 tcaccatgtg ggttttgaag accctcgact gcctccccga tgctccgaag cctgatctta   2820
 cagggtgggg aggagaaaat cccacctccc ctgacctcca ccacctccac caccaccacc   2880
 accaccacca ccaccactac caccaccacc caactggggc tagagtgggg aagatttccc   2940
 ctttagatcc ctgccccttg gcctcacctc tccctcccac t                       2981



      <210> 2407
      <211> 696
      <212> DNA
      <213> Homo sapiens


      <400> 2407
 ccggcttggt ggcttcggga aacagtttgg cgccggcggc cgtccgtgtt actccgcatc     60
 ccgccccgtc tcggcacggc tagcagcccc ctggccacca gcgtccagca atgtgtctca    120
 ccggccgggc gtagcagctg cgcgtgcgcg gaaccgcggg gccatgagcg aagccggcgg    180
 ccggggctgt gggtccccgg ttccccagcg agcgcgatgg agactagtgg cggcgacggc    240
 cgcgttctgc ctggtgtcgg ccacctccgt gtggacggcg ggggccgagc ccatgagtag    300
 ggaggagaaa cagaagcttg ggaatcaagt actggaaatg tttgatcatg cttatggtaa    360
 ctatatggaa catgcttacc ctgctgatga actcatgcct ttaacctgta gaggtcgagt    420
 tagaggccaa gagccaagtc gcggtgacgt tgatgatgcc ttgggaaaat tttctctgac    480
 actgattgat tctttggaca ctcttgtggt aggtttgact cttcttggat ttattttatt    540
 catgatatgc acacttaagt attatgaata tgatcataac acagttttaa ataaaactaa    600
 agaatttgaa gatgcagtga gaaaagtttt aagagatgtt aatttagata acgatgtagt    660
 cgtatcagtc tttgaaacaa acatcagagt tcttgg                              696



      <210> 2408
      <211> 727
      <212> DNA
      <213> Homo sapiens


      <400> 2408
 gatgagaacc ctctaaagca cgctgggtga cctcagatgg ctccgctggg actggaaggt     60
 cactggagcc actggtgaaa atgatgctgt cactaccaac tcaaaaggtc acctatcagt    120
 gtgccatgtg ccacctcctg gagcacacac atgtgcacac acatacactc acacgtgtgt    180
 gcaggtgcac acctccccca gaggctgcag ccaagacggg catcccacat catagggatg    240
 aatggcaggt ctgtcccgcc agctgtgtgc tctctcccac ccgaagaaag cagcagagac    300
 tcagacggcg gagcctggag gagcccacgc agtctgttcc cggcacccgg tgcgtgtgaa    360
 gggacttgag ggcagcgaga tggaatcagc aagagaaaac atcgaccttc aacctggaag    420
 ctccgacccc aggagccagc ccatcaacct gaaccattac gccaccaaaa aaagcgtggc    480
 ggagagcatg ctggacgtgg ccctgttcat gtccaacgcc atgcggctga aggcggtgct    540
 ggagcaggga ccatcctctc actactacac caccctggtc accctcatca gcctctctct    600
 gctcctgcag ggggtcatcg gtgtcctgct cgtggtcatt gcacggctga acctgaatga    660
 ggtagaaaag cagtggcgac tcaaccagct caacaacgca gccaccatct tggtcttctt    720
 cactgag                                                              727



      <210> 2409
      <211> 1280
      <212> DNA
      <213> Homo sapiens


      <400> 2409
 gcaatttttt gaccatctcc actggaagac agagaatggc ttcagggccg ggcacttgtg     60
 tcttcctgag tttcatgttc cccaatccta ccattggtat gtagtaggta ctcagagctt    120
 ttttactgaa tgagtcaact ggtgagtaat aaagaaagca ggaaggagtg gctgagtgaa    180
 gaaatctgga aagaaggaag ggagggaaaa caccaggtag gaaatgagtg aacgatggaa    240
 gaggagaggg aattcaacaa ggacctcctc tttggcttca ggagctgggg accctgaacc    300
 agacctgtgg atcatccagc cccaggaatt ggtgttgggg accactggag acactgtctt    360
 tctgaactgc acagtgcttg gagacggtcc ccctggaccc atcaggtggt tccagggagc    420
 tggtctgagc cgggaggcca tttacaactt tggaggcatc tcccacccca aggcgacagc    480
 ggtgcaggcc tccaacaatg acttcagcat tcttctgcaa aacgtctcca gtgaggatgc    540
 aggcacctat tactgtgtaa agtttcagag gaaacccaac aggcaatacc tgtctggaca    600
 gggcaccagc ctgaaagtga aagcaaaatc tacctcttcc aaagaggcag aattcaccag    660
 tgaacctgca actgagatgt ctccaacagg cctcctggtt gtgttcgcac ctgtggtcct    720
 ggggctgaag gcaattacct tggctgcact cctactggcc ctggctacct ctcggaggag    780
 ccctgggcaa gaagatgtca agaccacagg cccagcagga gccatgaaca ccttatcatg    840
 gagcaagggt caagagtgag gggtcagccc cagagtgagg accctctgag ttggagagga    900
 gccagggctc ctcaaccatt tccctacctc cagtcccagc ctctaggtgc ccccaggcct    960
 catgacaaac tcctagatcc ctacatctgg ttttggtcca cctagtgaaa ttcccttctt   1020
 tgcaccgggc ttccctctaa aatgtctccc tttctctttt tggcctgttc aagacctcct   1080
 tgcttttcag tccctggctc agtctctcct caacaccctt gcccctgctg cagccctttc   1140
 tggtgcgccc tgcccctttc cccacctcgc tacatccttc ttggcctcca acatccaact   1200
 cagagtcttc ttcccaggag atgtctgtaa gaatctctga actcaaccag ccagaccatc   1260
 tgtgcccctc catttacacc                                               1280



      <210> 2410
      <211> 502
      <212> DNA
      <213> Homo sapiens


      <400> 2410
 tttcgtggcc gggctgcggc tgaggcggcg gcggcgcccc gcttctgttg aggttgccgg     60
 ggccgcgcgc gctgatctgc gagtgaagag ggacgaggga aaagaaacaa agccacagac    120
 gcaacttgag actcccgcat cccaaaagaa gcaccagatc agcaaaaaaa gaagatgggc    180
 cccccgagcc tcgtgctgtg cttgctgtcc gcaactgtgt tctccctgct gggtggaagc    240
 tcggccttcc tgtcgcacca ccgcctgaaa ggcaggtttc agagggaccg caggaacatc    300
 cgccccaaca tcatcctggt gctgacggac gaccaggatg tggagctggg ttccatgcag    360
 gtgatgaaca agacccggcg catcatggag cagggcgggg cgcacttcat caacgccttc    420
 gtgaccacac ccatgtgctg cccctcacgc tcctccatcc tcactggcaa gtacgtccac    480
 aaccacaaca cctacatgta tt                                             502



      <210> 2411
      <211> 967
      <212> DNA
      <213> Homo sapiens


      <400> 2411
 cttaaaaaga ggccgatttc atctcaaacc ctggtgcaga ggtcctaggc agagtgggaa     60
 acttgccctg gagaagcaga agcagagacc aaatggctat ctagtaagga tgttttataa    120
 tgaatccttc attcctttaa agagcccatt attttctgag gcttcatggg atgcgtaata    180
 gcccatgcct tcactgctaa gcataaaaca tggagctctt agtagcctct aagacaatca    240
 tccgtcattc ccacgattgc cttcatcaag gccaggtact aaagaagtgc tcaaagaaat    300
 acacatttct gatacaacag ctgatgtaat tttttatccc atttatagaa tgagtgagat    360
 gatatttcga agaataaaga tgccctggct ttggcttgat ctctggtacc ttatgtttaa    420
 agaaggatgg gaacacaaaa agagccttaa gatcctacat acttttacca acagtgtcat    480
 cgcggaacgg gccaatgaaa tgaacgccaa tgaagactgt agaggtgatg gcaggggctc    540
 tgccccctcc aaaaataaac gcagggcctt tcttgacttg cttttaagtg tgactgatga    600
 cgaagggaac aggctaagtc atgaagatat tcgagaagaa gttgacacct tcatgtttga    660
 ggtattgtat attgttaggt tcagatatca ttaaacaaat ttcagttatt gttagaatct    720
 ttatcattat tttttaaaac aatcatattt tagagtaggt taactaaaga agactcatta    780
 tattttaatt agaaattaca aaatttaaga aactgattaa gtaccagctc aacttcttca    840
 gaaaacgatt ttgactagtg ctgggcacag cagtagacac atttgttttt cctcaagaaa    900
 acctaagatt tgtcagagtt ttcccaagca gaagagcagc cagagattgc tctcagttct    960
 ccatgtg                                                              967



      <210> 2412
      <211> 449
      <212> DNA
      <213> Homo sapiens


      <400> 2412
 gcacagaggt gctaggcagc aaaggcattc atgagcttcg gagcagcacc agtgccctgc     60
 accatgccct agaggagtcg gcttccctcc tcaccatgtt ctggagagcg gccctgccaa    120
 gcacccacat ccctgtgctg cctggcaaag tgggagaatc aacagaaagg gaacttctgg    180
 aactgagaac caaagtatcc caacaggagc agctccttca gagcacaact gagcatctga    240
 agaacgccaa ccagcagaag gagagcatgg aacagttcat tgtcagccag ctaaccagaa    300
 cacatgatgt tttaaagaag gcaaggacta acttagaggt aaggaaacta ctgcaccagt    360
 cagaggcacc aagcctgtcc cccacccatc accatccgtt agcagatctt gtaggtgact    420
 cttggcctgc tttgcgcttc caggagaag                                      449



      <210> 2413
      <211> 1104
      <212> DNA
      <213> Homo sapiens


      <400> 2413
 gcggctacaa tttcctgcgc gcggaggcgg acgtcgcgcc cagcctgtgc ccacacattt     60
 tcgtttagcc aggcgccgga cccagcttca gagcggctga aatcttggag ggaagaaaac    120
 acatcccacc ctgcctccgg gaaggggcct ctcctggaca tgtctcctgc agctgctgct    180
 gagccagatg gggaccagca ggacagacac gtcagcaaac tcatcctctg cttctttgtc    240
 ttcggcgccg ccttgttgtg tgtgggagtc ctgctctcca tctttgggtt ccaggcatgc    300
 caatataagc ccctcccaga ctgccccatg gtgctcaagg tggcggggcc tgcatgtgcc    360
 gcggttgggc ttggggctgt gatcctggcc cgctcccggg cgcaacttca gctccgtgca    420
 gggctgcaga gaggtcagca gatggacccc gaccgagcct tcatctgtgg agagagccgc    480
 cagtttgccc agtgccttat ctttgggttt ctgttcttga caagcggcat gctcatcagc    540
 gtcctgggca tttgggtccc tggatgtggc tccaactggg cgcaggaacc gctaaacgag    600
 acagacactg gcgactcaaa gccccggatg tgtgggttcc tttctctgca gatcatgggg    660
 cccttgattg tgcttgtggg attgtgtttc ttcgtggttg cccatgttaa gaagagaaac    720
 acgctgaatg ctggccagga tgcctctgag agagaagagg gacagatcca gattatggag    780
 cctgtccagg tcactgtagc tgctcagagc cgcaaggggc tggaagttgg gcagggtggg    840
 aggtcccatg tcaaagctga agatgaaaga gaaaccaggc cagcagtcat ccaacaagat    900
 ctagtggccc tgatgaagcc agacaaaaat gtaatacaga tgacacaggc cagccaggcg    960
 aggattcaag tacagcacgt cacaggaccc tgtcagtggc caccactacc tggcaatcct   1020
 gagatgatca acaaaatcag aaaaggtccg gatgacaaaa tcagactcca gaggaaggtg   1080
 gttcatgggt ccacgtggat gtga                                          1104



      <210> 2414
      <211> 1952
      <212> DNA
      <213> Homo sapiens


      <400> 2414
 cggacgcgtg gggaagaaac ctatgcaaat tttataaagc acaatgatgg caaaaatatc     60
 ttctatgctg ctcgtacccc agccacactg tttgcggtca tgtttgctat gtatataatc    120
 tcaggactga ctggcttcat tggcctaaac tctatagctg tcttgtgtaa ccttgtcatg    180
 gggttagcac tgatatttct ttgtacttgg gcatatgtta aatactctgg ggagttcaga    240
 gaaattggaa cagtgattga tcagattgct gaaacactat gggaacaggt attgaagccc    300
 ctgggtgata atttgatgga ggaaaacata aggcagtctg taacaaactc tatcaaagca    360
 ggcctgactg accaggtgtc tcatcatgcc agattaaaga cagactgaca gttcatctcc    420
 tcacggactc cactctcttt ttttttcatg cttgctgtac aatgagaact caaataaaaa    480
 taaaccaaag tttacaatca actgtagaag tagtttagtg taactggctt cacagatggc    540
 tgccacagag tgtgaagatt gtttgttagt tttaagcatt cttttaatgg ctcctaagac    600
 atgcagatgg actgaggagc attggttaat catgcacctt tgtgccatgt ttaactcttt    660
 tatttctttt tacttaatct aatgttagtg aatttgtctt atgtaaaagg atatttcagg    720
 gaaatatttt cagaaatcta tttagagtct ctttaacaca gtgtcccatt gaaattttaa    780
 tttttagaga atttatgaat cactgtttca agaaccagat tggaaagaca atgaagcctt    840
 tattgagcca ctacattaaa agtatatatt gctttactgc cttcaatacc agtattacat    900
 aaatgcatgt atcagaaact tcacagaaat tacatggcaa ctcttgtagc taagaaagta    960
 attctgaggt gtacatttgt cttgcctttt taaatttata aacttgccct aaaaggagat   1020
 gcatatctgg gaaactgaac tgtctttttg cagtttagcc ttcatgtata taaaatatgc   1080
 cattaatttt attggggaag aaattccatc caaaaatgtt gcctacagct atgagttaag   1140
 agtgtctgta cagtgtgtag cttttatttt ctaaaatcac agatagggca tgtatatgac   1200
 ttataaatat ataaatacga ttttgtatta aaagttttgt agtttatggc aaaatctggt   1260
 cctgtggtag gctaaataag tactgtccct gtgaaaggaa tgtttgtggc tcatgtcagt   1320
 gtgtgaatgc atagacaatt tgaagttttt gatatatttg tgatatttat cttgagcact   1380
 gcaatctcac cccccccccg cccaccaagg gaattcaatg ggaatgttta ttgtgacttt   1440
 gtcctctgtt gcattttaaa gttatttcct gtaatttatt ttcagtacat aattaaaaat   1500
 ttgttgtata tataaaatga aacttgtgat tcttttttaa ggaatttttc aagtatgtat   1560
 tccacttcat aaaccacatt tgtttatagt gaaaagagca tgagcaggaa acaccccagt   1620
 tgagagctct aaggcattgt acctcaaaac taagcttgta aaaagttact tttctgtgtc   1680
 tgtctctata agggaaaacc tatgattagc ctagttgtag atggggattg ttaatttctt   1740
 tctctctctt tttttttttt tggggggata tgaaagggta acattttttc aaaacttttg   1800
 gggccttttt tgggaacccc gataaaggcc ctagttttgg tgggtttttt tttgaaaagg   1860
 gatttttttt ttgcccccag ggtggaaggg cgggggggcg atcttggttt aatggaaccc   1920
 cccccttcgg ggttaaaggg aatttccccc cc                                 1952



      <210> 2415
      <211> 1106
      <212> DNA
      <213> Homo sapiens


      <400> 2415
 actgtggtgg aattcgagcg tcaaatgaag agaggtaccg actcctgtcc cacccaggac     60
 tcagccttca gcctccagcc ttctgaggca gagtaggcat ttctgcacgt ctgcaaaagg    120
 aagggaggga agcactccat catctcactg ggaagaacgg cacgggcata cctgcagcta    180
 ctggggttcc actgggcttg agggtcgatt tttcaccttt tgaaggacaa gatgcattgg    240
 aagatgttgc tgcttctgct gttgtattac aatgctgagg cttctatgtg ccacaggtgg    300
 agcagggctg tgctcttccc tgccgcccac cggccaaaga ggtcctcatc actgccattg    360
 aacccagtcc tgcagacctc cctggaggag gtggagctgc tctacgagtt cctgctggcc    420
 gaacttgaga tcagccctga cctgcagatc tccatcaagg acgaggagct ggcctccttg    480
 cggaaggcct cagacttccg caccgtctgc aacaacgtca tccccaagag catcccagac    540
 atccgccggc tcagcgccag cctctccagc caccctggca tcctcaagaa agaagacttt    600
 gaaaggacag tgctgaccct ggcctacaca gcctaccgca cagccctgtc ccacggccat    660
 cagaaggaca tctgggcgca gtccctcgtt agcctcttcc aggccctgag gcacgacttg    720
 atgcgctcct cacagccggg agtacctccc tgagagactg gcccacacca ggacctcaga    780
 gcagggacca gcacagtaat ccagaaagtc ttcattctct actccattta cagagaccag    840
 caacaaaaca cttaccgctg acacagagca gcagagatca aacagtaacc ccgatgctct    900
 tttctccttg tagtttcctg gaagacacat ctgattcatg ccatcatgtg acctgggctg    960
 gaagaaaggg ctggaatggt cattcaagac gcctccatgg gcagaatggt ttgcctatgg   1020
 caggcagaat tctgatatgc ttcaacccag agcagtggcc acacactcaa gagtgagaac   1080
 aggccgggca cagaggctca cgcctg                                        1106



      <210> 2416
      <211> 1299
      <212> DNA
      <213> Homo sapiens


      <400> 2416
 gaagaggtcc agttctttgc aaacaccagt gggtccttcc tgtgtgttta tagtttgaat     60
 tccttcaact acacccacag tccaaaagca gactcactgt gtcccaggct accagttcct    120
 ccaagcaagt catttccctt atttaaccga tgtgtccctc aaacacctga gtgctactcc    180
 ctatttgcat ctgttttgat aaatgatgtt gacaccctcc accgaattct aagtggaatc    240
 atgtcgggaa gagatacaat ccttggcctg tgtatcctcg cattagcctt gtctttggcc    300
 atgatgttta ccttcagatt catcaccacc cttctggttc acattttcat ttcattggtt    360
 attttgggat tgttgtttgt ctgcggtgtt ttatggtggc tgtattatga ctataccaac    420
 gacctcagca tagaattgga cacagaaagg gaaaatatga agtgcgtgct ggggtttgct    480
 atcgtatcca caggcatcac ggcagtgctg ctcgtcttga tttttgttct cagaaagaga    540
 ataaaattga cagttgagct tttccaaatc acaaataaag ccatcagcag tgctcccttc    600
 ctgctgttcc agccactgtg gacatttgcc atcctcattt tcttctgggt cctctgggtg    660
 gctgtgctgc tgagcctggg aactgcagga gctgcccagg ttatggaagg cggccaagtg    720
 gaatataagc ccctttcggg cattcggtac atgtggtcgt accatttaat tggcctcatc    780
 tggactagtg aattcatcct tgcgtgccag caaatgacta tagctggggc agtggttact    840
 tgttatttca acagaagtaa aaatgatcct cctgatcatc ccatcctttc gtctctctcc    900
 attctcttct tctaccatca aggaaccatt gtgaaagggt catttttaat ctctgtggtg    960
 aggattccga gaatcattgt catgtacatg caaaacgcac tgaaagaaca gcatggtgca   1020
 ttgtccaggt acctgttccg atgctgctac tgctgtttct ggggtcttga caaatacctg   1080
 ctccatctca accagaatgc atatactaca actgctatta atgggacaga tttctgtaca   1140
 tcagcaaaag atgcattcaa aatcttgtcc aagaactcaa gtcactttac atctattaac   1200
 tgctttggag acttcataat ttttctaaga aaggggttaa gggtgtgttt cactggtttt   1260
 ggaagaactc aatgctttta actacaatcg gcatttcag                          1299



      <210> 2417
      <211> 4197
      <212> DNA
      <213> Homo sapiens


      <400> 2417
 gccctgctgc ccctgagcac acggacccgt ccgaaccgcg gggcagtgtg tcctgctgct     60
 ccctgctgcg gggactgtcc tcagggtggt cctcacctct gcttccggcc cctgtgtgca    120
 accctaacaa ggccatcttc acggtggatg ccaagaccac agagatcctc gttgctaacg    180
 acaaagcttg cgggctcctg gggtacagca gccaggacct gattggccag aagctcacgc    240
 agttctttct gaggtcagat tctgatgtgg tggaggccct cagcgaggag cacatggagg    300
 ccgacggcca cgctgcggtg gtgtttggca cggtggtgga catcatcagc cgtagtgggg    360
 agaagattcc agtgtctgtg tggatgaaga ggatgcggca ggagcgccgc ctatgctgcg    420
 tggtggtcct ggagcccgtg gagagggtct cgacctgggt cgctttccag agcgatggca    480
 ccgtcacgtc atgtgacagt ctctttgctc atcttcacgg gtacgtgtct ggggaggacg    540
 tggctgggca gcatatcaca gacctgatcc cttctgtgca gctccctcct tctggccagc    600
 acatcccaaa gaatctcaag attcagaggt ctgttggaag agccagggac ggtaccacct    660
 tccctctgag cttaaagctg aaatcccaac ccagcagcga ggaggcgacc accggtgagg    720
 cggcccctgt gagcggctac cgggcatctg tctgggtgtt ctgcaccatc agtggcctca    780
 tcaccctcct gccggatggg accatccacg gcatcaacca cagcttcgcg ctgacactgt    840
 ttggttacgg aaagacggag ctcctgggca agaatatcac tttcctgatt cctggtttct    900
 acagctacat ggaccttgcg tacaacagct cattacagct cccagacctg gccagctgcc    960
 tggacgtcgg caatgagagt gggtgtgggg agagaacctt ggacccgtgg cagggccagg   1020
 acccagctga ggggggccag gatccaagga ttaatgtcgt gcttgctggt ggccacgttg   1080
 tgccccgaga tgagatccgg aagctgatgg aaagccaaga catcttcacc gggactcaga   1140
 ctgagctgat tgctggaggc cagctccttt cctgcctctc acctcagcct gctccagggg   1200
 tggacaatgt cccagaagga agcctgccag tgcacggtga acaggcgctg cccaaggacc   1260
 agcaaatcac tgccttgggg agagaggaac ctgtggcaat agagagcccc ggacaggatc   1320
 ttctgggaga aagcaggtct gaaccagtgg atgtgaagcc atttgcttcc tgcgaagatt   1380
 ctgaagctcc agtcccagct gaggatgggg gcagtgatgc tggcatgtgt ggcctgtgtc   1440
 agaaggccca gctagagcgg atgggagtca gtggtcccag cgggtcagac ctttgggctg   1500
 gggctgccgt ggccaagccc caggccaagg gtcagctggc ggggggcagc ctcctgatgc   1560
 actgcccttg ctatgggagt gaatggggct tgtggtggcg aagccaggac ttggccccca   1620
 gcccctctgg gatggcaggc ctctcgtttg ggacacctac tctagatgag ccgtggctgg   1680
 gagtggaaaa cgaccgagaa gagctgcaga cctgcttgat taaggagcag ctgtcccagt   1740
 tgagccttgc aggagccctg gatgtccccc acgccgaact cgttccgaca gagtgccagg   1800
 ctgtcaccgc tcctgtgtcg tcctgcgatc tgggaggcag agacctgtgc ggtggctgca   1860
 cgggcagctc ctcagcctgc tatgccttgg ccacggacct ccctgggggc ctggaagcag   1920
 tggaggccca ggaggttgat gtgaattcgt tttcctggaa cctcaaggaa ctctttttca   1980
 gtgaccagac agaccaaacg tcatcaaatt gttcctgtgc tacgtctgaa ctcagagaga   2040
 caccctcttc cttggcagtg ggctccgatc cagatgtagg cagtctccag gaacaggggt   2100
 cgtgtgtcct ggatgacagg gagctgttac tactgaccgg cacctgtgtt gaccttggcc   2160
 aaggccgacg gttccgggag agctgtgtgg gacatgatcc aacagaaccg cttgaggttt   2220
 gtttggtgtc ctctgagcat tatgcagcaa gcgacagaga aagcccagga cacgttcctt   2280
 ccacgttgga tgctggccct gaggacacgt gcccatcagc agaggagcca aggctgaacg   2340
 tccaggtcac ctccacgccc gtgatcgtga tgcgcggggc tgctggcctg cagcgggaga   2400
 tccaggaggg tgcctactcc gggagctgct accatcgaga tggcttacgg ctgagtatac   2460
 agtttgaggt gaggcgggtg gagctccagg gccccacacc tctgttctgc tgctggctgg   2520
 tgaaagacct cctccacagc caacgcgact cagccgccag gacccgcctg ttccttgcca   2580
 gcctgcccgg ctccacccac tctaccgctg ctgagctcac cggacccagc ctggtggaag   2640
 tgctcagagc cagaccctgg tttgaggagc cccccaaggc tgtggaactg gaggggttgg   2700
 cggcctgtga gggcgagtac tcccaaaagt acagtaccat gagcccgctg ggcagtgggg   2760
 ccttcggctt cgtgtggact gctgtggaca aggaaaaaaa caaggaggtg gtggtgaagt   2820
 ttattaagaa ggagaaggtc ttggaggatt gttggattga ggatcccaaa cttgggaaag   2880
 ttactttaga gatcgcaatt ctatccaggg tggagcacgc caatatcatc aaggtattgg   2940
 atatatttga aaaccaaggg ttcttccagc ttgtgatgga gaagcacggc tccggcctag   3000
 acctcttcgc tttcatcgac cgccacccca ggctggatga gcccctggcg agctacatct   3060
 tccgacaagt gagagcaggg ccagagccgt ctagtgtcag cagtgggata cctgcgcttg   3120
 aaggacatca tccaccgtga catcaaggat gagaacatcg tgatcgccga ggacttcaca   3180
 atcaagctga tagactttgg ctcggccgcc tacttggaaa ggggaaaatt attttatact   3240
 ttttgtggga ccatcgagta ctgtgcaccg gaagttctca tggggaatcc ctacagaggg   3300
 ccggagctgg agatgtggtc tctgggagtc actctgtaca cgctggtctt tgaggagaac   3360
 cccttctgtg agctggagga gaccgtggag gctgccatac acccgccata cctggtgtcc   3420
 aaagaactca tgagccttgt gtctgggctg ctgcagccag tccctgagag acgcaccacc   3480
 ttggagaagc tggtgacaga cccgtgggta acacagcctg tgaatcttgc tgactataca   3540
 tgggaagagg tgtttcgagt aaacaagcca gaaagtggag ttctgtccgc tgcgagcctg   3600
 gagatgggga acaggagcct gagtgatgtg gcccaggctc aggagctttg tgggggcccc   3660
 gttccaggcg aggctcctaa tggccaaggc tgtttgcatc ccggggatcc ccgtctgctg   3720
 accagctaaa caccaatttc ttcctgcttt tctccacttg gtttggaaaa tcacacagtt   3780
 ttcaggctcc atctgtttgg agaaaataca ttctgaagca tccccaattc accttctaaa   3840
 aactcatgtg caggtttgat aaacaccaga acagaagaca gtgatgctgt attattttag   3900
 atttattaca tagatttgga attcactttt ttcatgacct agaaaaaaac attccagtgt   3960
 tcaactgttt tatattatta aagggctttt aatttgtgaa cttctgaagg catgagtgtt   4020
 ttctctttct acttttgtat atgtgcatgt tttgtttcct ctgacttggt atatgctcat   4080
 ctgagtgacg gatatgtgaa atttgtagaa ctggttagtc aaatggccag actatttcat   4140
 taatttattt cctcaaatgc ttttcaaatt aaagcacctt tgttagtaaa cagttaa      4197



      <210> 2418
      <211> 416
      <212> DNA
      <213> Homo sapiens


      <400> 2418
 cccacgatat gaaagcattc attggagatg tggcccagta cttttgtggt ttattttatt     60
 tttatatcta aatctttgat ctacctggaa tgtggcagtc cagattgttt ttctcagaca    120
 ggcggccagt tgtgccaacg ccatcttttg ccacttaggt gaaatatgtc ttttatcata    180
 aactaaactt ccaggccagc tttgacctgg cattggatgg cagccccagg ctcccagcac    240
 ttgtcctctc ttctctccag gtgaccgaga gcgagcccag cgtgatgtgg ctctcggggc    300
 tgcacatccc tgagtcctac ctcacggcgc tggtgcaggc cacctgccgg aagaacggct    360
 ggccactgga ccgctccaca ttgttcacac aagtgaccaa gttccaggat gcagat        416



      <210> 2419
      <211> 1803
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> misc_feature
      <222> (1)...(1803)
      <223> n = a,t,c or g


      <400> 2419
 tttttttttt ttgccacagg ttggacaggt ttttattgga gagtcaggag ttgctttcct     60
 tccctcgtcc ctgcctcccc cactcaaaga accccactcc agtggggctt gtccttcatc    120
 tgcccctagg aatccccatc cccagctaca caggcactca gggagagcgc acatgctgtg    180
 tgggcagaca gccccaggcc aggtaggcag tgagctccct caaatcctcc cacccccagg    240
 actcaggagg gaggggcagg agaggtgtgg gcccggtgtg cagtcctcag gcggccccct    300
 gagctcgcag ccagccaggc cttgtgcctc caggatggat ggtgtgatga ggcacatgcc    360
 ccgtagcctt tcccttccgg agggccttaa ccaagaagta tcttgtttag gggctgggga    420
 cagggtgggg aagatgacag gaggacagct gacctcttca ccctttgagt ggtatcccct    480
 tcagaagatt ccagccaaca ccagaggagg caggagcagt agtcccagga gagggcccca    540
 cacatgacca gggcccgagt tcagccctga cacgacgcta ggcttgtcag ggccctctgc    600
 acccattttc ctagagtctg atgcttcagt cgcccggaag gatggggcct cagttaccag    660
 gtaaggcaaa tcctgagcat cttccgggct tccgatgggt tcacagaggg agttcttgca    720
 gtggtagcca gagggacatt gggagcacgg agtcccctcc tggtagggcc gtttcccctt    780
 cacgttcccc ggaggctcat agttgcacac cagtaattcg atgttggtct cctcaacacc    840
 ctggagcttc tcacagaagt gggaaccaca gccgatcctc tctgtcttgg cccataccac    900
 ctgcgtgtag tggccgcaca tctggcctgg gctgcaggtg gcggcgctga ggttgtagtg    960
 ctcacgctcg tggtgccact cctccatggc cagcggcacg tccatgccct cgtctgtgat   1020
 ggcgaacaga ttctcgccgc ggcgcccgcg ctccttgttg tggccccaca cgcactgccg   1080
 tgcgtaggcc ttggcgaagg cggccagctc ctcgtcccat ctcatgtgca gcatgtctga   1140
 ggccgtcggg gatacctggg cccggtagag gttgtgcagc tccaccatca aacgtttctc   1200
 ctcatctgtg agggctccaa cggggcctgt ggtggccacc agcagtagca gtagcggcag   1260
 cagaagcatc aggaaactgc aggagccgtg catggtggcc agccgtctct ccttctcccg   1320
 tccaggggtc tggcagctgg atttaaagtc cttcccacac aagcaccacc ctggctgggg   1380
 tggggtagtg ggggccgtgt ttgaggccca gcccgactca cacaatgtct cagggagggc   1440
 tgggcgcttt gggtcccgac cagcatcaag tgcactcccc ttggagtcct tggcaaaaac   1500
 ctcctttctc ttggtaacgg gggctcaggc caaaagctgt gtgagttcct aagttgtgga   1560
 cagatccatt agggaaatac agtgaaatac cacttcacac tcattaggat ggctggcctg   1620
 ggaagtgctg gactcaggaa tgcaaggaca cagttctcag atgccccccg ggtggaacca   1680
 ggcactggca ctacagaatg ccctggtgtg gtcatctctg tggcctctgc caccagtcct   1740
 gcccctncnn nggnnnnttc nagtatcnat taganaccct ggagnnngaa gcctggcaac   1800
 tct                                                                 1803



      <210> 2420
      <211> 2338
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> misc_feature
      <222> (1)...(2338)
      <223> n = a,t,c or g


      <400> 2420
 tttttttttt ttgtagagac tggggtctca ctatgttgcc cacgctggtc tcaaactcct     60
 gggctcaagc gatcctcccg cttcagcctc ccaaggtgct gggattacag gtggagccac    120
 cgcgcccggc atcgataatc tgaatctcta acgagctccc gggcgacgtt gatgcagctg    180
 gtaccgggac cactcttcga aaatcatcgg tttagaggtt ttaattctga atccattgcg    240
 aaaactgttg ggcggacaga gcactactaa ctcctaactt ttctcagaaa gctgggctct    300
 gctttcgcca gcaacccggt ccgaagtcgc gggcatattc tgtctgaaat cgtgtgcacc    360
 gaaatccccg ccttgcggtg gaggctggcg ctaggcggcc tcagcctcgg cctgctgcgc    420
 tcaggaaccc gcgccccggc tcctcggcga tccattgctc tttcctctgg cgccggccgc    480
 aggcctcggt cacgccccca gcggcccgtt ggtttccggg tcccgcgggg tgcccccgcc    540
 cacacgctat gccttaaatt gggccaggct gaggcgctgc tgctggagcg gccgatccga    600
 gacgtggctc cctgggcggc agaaccatgt tggacttcgc gatcttcgcc gttaccttct    660
 tgctggcgtt ggtgggagcc gtgctctacc tctatccggc ttccagacaa gctgcaggaa    720
 ttccagggat tactccaact gaagaaaaag atggtaatct tccagatatt gtgaatagtg    780
 gaagtttgca tgagttcctg gttaatttgc atgagagata tgggcctgtg gtctccttct    840
 ggtttggcag gcgcctcgtg gttagtttgg gcactgttga tgtactgaag cagcatatca    900
 atcccaataa gacattggac ccttttgaaa ccatgctgaa gtcattatta aggtatcaat    960
 ctggtggtgg cagtgtgagt gaaaaccaca tgaggaaaaa attgtatgaa aatggtgtga   1020
 ctgattctct gaagagtaac tttgccctcc tcctaaagct tccagaagaa ttattagata   1080
 aatggctctc ctacccagag acccagcacc gtgcccctca gccagcatat gcttggtttt   1140
 gctatgaagt ctgttacaca gatggtaatg ggtagtacat ttgaagatga tcaggaagtc   1200
 attcgcttcc agaagaatca tggcacagtt tggtctgaga ttggaaaagg ctttctagat   1260
 gggtcacttg ataaaaacat gactcggaaa aaacaatatg aagatgccct catgcaactg   1320
 gagtctgttt taaggaacat cataaaagaa cgaaaaggaa ggaacttcag tcaacatatt   1380
 ttcattgact ccttagtaca agggaacctt aatgaccaac agatcctaga agacagtatg   1440
 atattttctc tggccagttg cataataact gcaaaattgt gtacctgggc aatctgtttt   1500
 ttaaccacct ctgaagaagt tcaaaaaaaa ttatatgaag agataaacca agtttttgga   1560
 aatggtcctg ttactccaga gaaaattgag cagctcagat attgtcagca tgtgctttgt   1620
 gaaactgttc gaactgccaa actgactcca gtttctgccc agcttcaaga tattgaagga   1680
 aaaattgacc gatttattat tcctagagag accctcgtcc tttatgccct tggtgtggta   1740
 cttcaggatc ctaatacttg gccatctcca cacaagtttg atccagatcg gtttgatgat   1800
 gaattagtaa tgaaaacttt ttcctcactt ggattctcag gcacacagga gtgtccagag   1860
 ttgaggtttg catatatggt gaccacagta cttcttagtg tattggtgaa gagactgcac   1920
 ctactttctg tggagggaca ggttattgaa acaaagtatg aactggtaac atcatcaagg   1980
 gaagaagctt ggatcactgt ctcaaagaga tattaaaatt ttatacattt aaaatcattg   2040
 ttaaattgat tgaggaaaac aaccatttaa aaaaaatcta tgttgaatcc ttttataaac   2100
 cagtatcact ttgtaatata aacacctatt tgtacttaat tttgtaaatt tggattttta   2160
 tatatcatat tttcttaatt cattgtacac atttgactta ctgcacagta tattgatcat   2220
 tttaatggga aactttagct ttctactttt tatttttgtt ttttcacttt ctatgccatt   2280
 atttttgcat tctttttctt agngngagct ctaaaatcaa tgttcttgaa aaagaaat     2338



      <210> 2421
      <211> 1223
      <212> DNA
      <213> Homo sapiens


      <400> 2421
 tttcgtccga aagatctcca tctgcatgtc gctgctgggc ttcctgctct cccgcctcgg     60
 gctgctgctc aaggtgctgc tggactggcc agtggaggtg ctgtacgggg cggcggcgct    120
 gaacgggcta ttcggcggct tctccgcctt ctggtccggg gtcatggcgc tgggatcgct    180
 gggctcctcc gagggccgcc gctctgtgcg cctcatcctc attgacctga tgctgggctt    240
 ggcggggttc tgcgggagca tggcttccgg gcatctcttc aagcagatgg ctgggcactc    300
 tgggcagggc ctgatactga cggcctgcag cgtgagctgt gcctcgtttg ccctgctcta    360
 cagccttttg gtgctaaagg tccctgagtc ggtggccaaa cccagccagg agctccccgc    420
 cgtggatacc gtgtctggca cggttggcac ataccgcact ctggatcctg atcagttgga    480
 ccaacagtat gcagtggggc accctccatc tcctggaaaa gcaaaacccc ataaaaccac    540
 cattgccttg ctctttgtgg gtgctatcat atatgacctg gcggtggtgg gcacagtgga    600
 cgtgatccct ctttttgtgc tgagggagcc tctcggttgg aaccaagtgc aggtgggcta    660
 tggtatggct gcagggtaca ccatcttcat caccagcttc ctgggtgtcc tggtcttctc    720
 ccgctgcttt cgggacacca ccatgatcat gattgggatg gtctcctttg ggtcaggagc    780
 cctcctcttg gcttttgtga aagagacata catgttctat attgctcgag ccgtcatgct    840
 gtttgctctc atccccgtca caaccatccg atcagctatg tccaaactca taaagggctc    900
 ctcttatgga aaggtgttcg tcatactgca gctgtccttg gctctgaccg gcgtggtgac    960
 atccaccttg tacaacaaga tctaccagct caccatggac atgtttgggg gctcctgctt   1020
 tgctctctcc tcctttctct ccttcctggc catcattcca attagcatcg tggcctataa   1080
 acaagtccca ttgtcaccat atggagacat catagagaaa tgaagatgct tacctgcagg   1140
 aactgaaaac atcagccatg gccaggcccc cagaagacaa aagaagggac cagggaactg   1200
 gtgacctaag caacccactg ctt                                           1223



      <210> 2422
      <211> 1317
      <212> DNA
      <213> Homo sapiens


      <400> 2422
 ggccctgaag ggatctcttg tccagaatta aacactgatc accagtggac cagagctgcc     60
 tggagcacat cttcactggg ctgcataatg gtttttaaaa aatcctggag cctctatttt    120
 agcatctcga tttgagatat gaagatccat gtttcttgag tttttcttaa acgacagaag    180
 attttgcttc ccagactagc atccctctgt ggctacaacc agcctgaacc gaggggtctg    240
 ccctttagaa gggcccagct cacgggctca ctgtgcactc aggccctagc cagcctgctg    300
 tacgtaggtg tttgcgattt catcattggc cttgttttaa cagacagcag agcagagcac    360
 ctgccataaa gcaagcctcg atgtgctaag tgccatgtgg agcccttgcc ctgctggggc    420
 tcgctgctcc catttgagct gccacagatc agcccctccc cccagggtct ccgaggagtc    480
 aggaccgcac agcctgccct cctagggaag gacttcctca gggaaggcag gcatgtggaa    540
 gccaggtgca gagtcctggc ctctccacac aggtgccgcc caggtgatgt ggtttgagaa    600
 gctgtatgct ggcctgcagt gcgtagagaa gtacctcatc taccccgccg tggtgctcaa    660
 cgccctcacg gtggacgccc acacagtcgt cagccacccg gacaagtact gcttctactg    720
 ccgggcgctg ctgatgaccg tggctgggct gaagctgctg cgctcagcct tctgctgccc    780
 cccacagcag tacctgacgt tggccttcac cgtcctgctc ttccactttg actacccgcg    840
 cctctcccag ggctttctgc ttgactactt cctcatgtcc ctgctttgca gcaagctgtg    900
 ggacttgctg tacaagctgc gtttcgtgct gacctacatc gcgccctggc agatcacctg    960
 gggctcggct ttccacgctt ttgcccagcc gtttgccgtg ccacactcgg ccatgctgtt   1020
 cgtccaggcc ctgctctcgg ggctcttctc cacgcctctc aacccactgc taggcagtgc   1080
 cgtcttcatc atgtcctacg ctcggcccct caagttctgg gagcgcgact acaacactaa   1140
 acgtgtggat cattccaaca cccgcctggt cacacagctg gacaggaacc ctggcgctga   1200
 tgacaacaac ctcaactcca tcttctatga gcacttgaca cgttcgctgc agcacacact   1260
 gtgtggggac ctggtgctgg gccgctgggg caactatggc cctggtgact gcttcgt      1317



      <210> 2423
      <211> 2976
      <212> DNA
      <213> Homo sapiens


      <400> 2423
 atgcacatca ccctccggca gttggaagtt tttgcagaag tattgaaaag tggatcaacc     60
 acccaggcgt cggtgatgct ggcgttgtcg caatcagcag tgagcgcagc cttgaccgac    120
 ctggaagggc cagcttggct tttgcggcgg cggtcggatg atgctgcgga cgcgtgcctt    180
 ccgatcgccg tgctggaaga tgccggcgta ccgtatcagc tgctggaatc cagccgcctg    240
 gcggaagtgg agcccgcgct ggcagaagtg gcgcacaaac tgacgggcgg cctgcagtta    300
 cccaatgatg aaaccggaga ctgtcagcta tttacccaga atctggcgcg gatggcggag    360
 caggcggggg ttaaattccg ctttaatacg cccgttgacc aactgctttg cgacggcgag    420
 caaatctacg gcgtgaagaa gattttggga ctggatgtgc tggtacatgg cgaggccgag    480
 cgtaatgaca tggtggaata ctttggcgag cacctcgacg gatttgtctt tacgcaaaac    540
 ggttgggtac agagctacgg ttcccgctgc gtgaagccac cgattgtcat tggtgacatt    600
 agccgcccgg caccgattac cgtggagtgg gcgaagtatg cgcaatcgct gaccgacaaa    660
 ccggtgaaag ggatgctgac ggggccggtg accatactct gctggtcgtt cccgcgtgaa    720
 gatgtcagcc gtgaaaccat cgccaaacag attgcgctgg cgctgcgtga tgaagtggcc    780
 gatctggaag ccgctggaat tggcatcatc cagattgacg aaccggcgct gcgcgaaggt    840
 ttaccgctgc gtcgtagcga ctgggatgcg tatctccagt ggggcgtaga ggccttccgt    900
 atcaacgccg ccgtggcgaa agatgacaca caaatccaca ctcacatgtg ttattgcgag    960
 ttcaacgaca tcatggattc gacctacgtg ccgatattct ttctcctgtc aaagaaaccg   1020
 gcacattgct gggcgtgttc acaagcggcg gaactctgcg gtctgaaggc gggcactccg   1080
 gtggtcgttg gaggaggcga cgtgcagctt ggttgtagag cggcggccaa aacgggctgt   1140
 ttgaaaaccc cggtaaccaa acggggccat acggaaaata acgcaaaggc agatgcgaaa   1200
 agctcgctgg cgctgattgg caccggcacc ctatttaatg acagttggca gcctgaaaca   1260
 ttagcggcag cgatgaagag caggcgcggc gcgtgctgga agagtacatc ccaggtgcgc   1320
 tattatccga cagcgcacag cgttcagcct acgcaggcag aactgacggc gcatccgctg   1380
 ccgcgttcat taagccgcct taacccggat ttactgtacg gcaatgtgct ggcaagcggc   1440
 gtcggcgatg atgaatttgc aggcaatatc cgtcgcctga tgacagaaca gcatcagggg   1500
 ctgggggcgg cgatcatcag caatatggag caggtttgcg ccaaactttc tgcctctgcc   1560
 agcgattatc tgcgcgaacg tgttagcgac attcgcgata tcagcgaaca gttgctgcat   1620
 atcacctggc cggaactgaa gccgcgcaac aagctggtgc ttgaaaaacc gaccattctg   1680
 gtggctgaag atttaacccc aagccagttt ttgagccttg atttgaaaaa tcttgcgggc   1740
 atgattctgg agaaaaccgg gcgcacctcg catacactga ttctggcccg tgcctcggcg   1800
 atcccggtac tgagtggctt gccgctggat gcgattgccc gttatgccgg gcaacctgca   1860
 gtgcttgacg cccagtgcgg cgtgctggcg attaacccga atgacgcggt gagcggttat   1920
 tatcaggtcg cgcagacgct ggcggataaa cgccaaaaac aacaggcgca ggctgccgcg   1980
 cagctggcct attcccgtga taaccagcgt attgatattg cggcgaatat cggcaccgct   2040
 ctggaagcgc caggcgcgtt tgccaacggc gcggaaggcg gcggacgagc agaacaattg   2100
 aagactacaa ccagtgcaac tggagcggtg acagcgatat ttcgacgagg aatgaggaat   2160
 aaatctactg aatccgaaag acctctgata gcgagttacg aaatggcgtc gcacgggcat   2220
 gggccattgg ccctaccgtc cccaattgag aaacattacg gtcaactgcc tgatgcgacg   2280
 cttgatgcgt cttatcagcg cgtgtttcat acgcaagtgc gtatcggcgc gccgctgaac   2340
 attaccggtt taacggatta tgctcaggag ccgtattatt cgacggcggt gggattgctt   2400
 cactatggga aagagtcaca tcttaacggt gaagctgaag tagaaaaacg tgttacagca   2460
 tcagttggct cgtggatcaa gcgactcaat agttggttgg tgatgcgttt gtccgcctgc   2520
 aatgccgcct gttctgcgcg ggccgccagt tcaatggctt catccgggga aacttccgca   2580
 gggtggaaca agtcgagatc tggtgcgtca aaggccagca gctctttgtc tgccacgccg   2640
 gcacagggat ctggcgaggt acaatcctgg atttaccctc cgaccataca gaatgagcta   2700
 ccgggaagtc aagtacttct cctttcctgg ggaacttctg atgaggatgt tacagatgct   2760
 ggtcttacca cttatcatct ccagtcttgt cacagtgaac gaggtgccct gctaaacacc   2820
 acaccatcag ccttctctga ccacagtgat gtagttgaca acagcgtaca acaggtctgt   2880
 tttctcaccc tcttatccca cccagataac atctggttgg acagcctatt agctattgat   2940
 gcaagaatgc ttgttctcag aaccaccagg acttga                             2976



      <210> 2424
      <211> 4650
      <212> DNA
      <213> Homo sapiens


      <400> 2424
 gggccgggcc gggctgggct ggagcagcgg cggccgcggg agccgagctt gcagcgaggg     60
 accggctgag gcgcgcggga gggaaggaga caagggctcc gcggcgctgt cgccgccgct    120
 accgctcact ctcggggaag agatggcggc ggagcgggga gcccggcgac tcctcagcac    180
 cccctccttc tggctctact gcctgctgct gctcgggcgc cgggcgccgg gcgccgcggc    240
 cgccaggagc ggctccgcgc cgcagtcccc aggagccagc attcgaacgt tcactccatt    300
 ttattttctg gtggagccgg tggatacact ctcagttaga ggctcttctg ttatattaaa    360
 ctgttcagca tattctgagc cttctccaaa aattgaatgg aaaaaagatg gaactttttt    420
 aaacttagta tcagatgatc gacgccagct tctcccggat ggttctttat ttatcagcaa    480
 tgtggtgcat tccaaacaca ataaacctga tgaaggttat tatcagtgtg tggccactgt    540
 tgagagtctt ggaactatta tcagtagaac agcgaagctc atagtagcag gtcttccaag    600
 atttaccagc caaccagaac cttcctcagt ttatgctggg aacaatgcaa ttctgaattg    660
 tgaagttaat gcagatttgg tcccatttgt gaggtgggaa cagaacagac aaccccttct    720
 tctggatgat agagttatca aacttccaag tggaatgctg gttatcagca atgcaactga    780
 aggagatggc gggctttatc gctgcgtagt ggaaagtggt gggccaccaa agtatagtga    840
 tgaagttgaa ttgaaggttc ttccagatcc tgaggtgata tcagacttgg tatttttgaa    900
 acagccttct cccttagtca gagtcattgg tcaggatgta gtgttgccat gtgttgcttc    960
 aggacttcct actccaacca ttaaatggat gaaaaatgag gaggcacttg acacagaaag   1020
 ctctgaaaga ttggtattgc tggcaggtgg tagcctggag atcagtgatg ttactgagga   1080
 tgatgctggg acttattttt gtatagctga taatggaaat gagacaattg aagctcaagc   1140
 agagcttaca gtgcaagctc aacctgaatt cctgaagcag cctactaata tatatgctca   1200
 cgaatctatg gatattgtat ttgaatgtga agtgactgga aaaccaactc caactgtgaa   1260
 gtgggtcaaa aatggggata tggttatccc aagtgattat tttaagattg taaaggaaca   1320
 taatcttcaa gttttgggtc tggtgaaatc agatgaaggg ttctatcagt gcattgctga   1380
 aaatgatgtt ggaaatgcac aagctggagc ccaactgata atccttgaac atgcaccagc   1440
 cacaacggga ccactgcctt cagctcctcg ggatgtcgtg gcctccctgg tctctacccg   1500
 cttcatcaaa ttgacgtggc ggacacctgc atcagatcct cacggagaca accttaccta   1560
 ctctgtgttc tacaccaagg aagggattgc tagggaacgt gttgagaata ccagtcaccc   1620
 aggagagatg caagtaacca ttcaaaacct aatgccagcg accgtgtaca tctttagagt   1680
 tatggctcaa aataagcatg gctcaggaga gagttcagct ccactgcgag tagaaacaca   1740
 acctgaggtt cagctccctg gcccagcacc taaccttcgt gcatatgcag cttcgcctac   1800
 ctccatcact gttacgtggg aaacaccagt gtctggcaat ggggaaattc agaattataa   1860
 attgtactac atggaaaagg ggactgataa agaacaggat gttgatgttt caagtcactc   1920
 ttacaccatt aatgggttga aaaaatatac agagtatagt ttccgagtgg tggcctacaa   1980
 taaacatggt cctggagttt ccacaccaga tgttgctgtt cgaacattgt cagatgttcc   2040
 cagtgctgct cctcagaatc tgtccttgga agtgagaaat tcaaagagta ttatgattca   2100
 ctggcagcca cctgctccag ccacacaaaa tgggcagatt actggctaca agattcgcta   2160
 ccgaaaggcc tcccgaaaga gtgatgtcac tgagaccttg gtaagcggga cacagctgtc   2220
 tcagctgatt gaaggtcttg atcgggggac tgagtataat ttccgagtgg ctgctctaac   2280
 aatcaatggt acaggcccgg caactgactg gctgtctgct gaaacttttg aaagtgacct   2340
 agatgaaact cgtgttcctg aagtgcctag ctctcttcac gtacgcccgc tcgttactag   2400
 catcgtagtg agctggactc ctccagagaa tcagaacatt gtggtcagag gttacgccat   2460
 tggttatggc attggcagcc ctcatgccca gaccatcaaa gtggactata aacagcgcta   2520
 ttacaccatt gaaaatctgg atcccagctc tcactatgtg attaccctga aagcatttaa   2580
 taacgtgggt gaaggcatcc ccctgtatga gagtgctgtg accaggcctc acacagacac   2640
 ttctgaagtt gatttatttg ttattaatgc tccatacact ccagtgccag atcccactcc   2700
 catgatgcca ccagtgggag ttcaggcttc cattctgagt catgacacca tcaggattac   2760
 gtgggcagac aactcgctgc ccaagcacca gaagattaca gactcccgat actacaccgt   2820
 ccgatggaaa accaacatcc cagcaaacac caagtacaag aatgcaaatg caaccacttt   2880
 gagttatttg gtgactggtt taaagccgaa tacactctat gaattctctg tgatggtgac   2940
 caaaggtcga agatcaagta catggagtat gacagcccat gggaccacct ttgaattagt   3000
 tccgacttct ccacccaagg atgtgactgt tgtgagtaaa gaggggaaac ctaagaccat   3060
 aattgtgaat tggcagcctc cctccgaagc caatggcaaa attacaggtt acatcatata   3120
 ttacagtaca gatgtgaatg cagagataca tgactgggtt attgagcctg ttgtgggaaa   3180
 cagactgact caccagatac aagagttaac tcttgacaca ccatactact tcaaaatcca   3240
 ggcacggaac tcaaagggca tgggacccat gtctgaagct gtccaattca gaacacctaa   3300
 agcggactcc tctgataaaa tgcctaatga tcaagcctca gggtctggag ggaaaggaag   3360
 ccggctgcca gacctaggat ccgactacaa acctccaatg agcggcagta acagccctca   3420
 tgggagcccc acctctcctc tggacagtaa tatgctgctg gtcataattg tttctgttgg   3480
 cgtcatcacc atcgtggtgg ttgtgattat cgctgtcttt tgtacccgtc gtaccacctc   3540
 tcaccagaaa aagaaacgag ctgcctgcaa atcagtgaat ggctctcata agtacaaagg   3600
 gaattccaaa gatgtgaaac ctccagatct ctggatccat catgagagac tggagctgaa   3660
 acccattgat aagtctccag acccaaaccc catcatgact gatactccaa ttcctcgcaa   3720
 ctctcaagat atcacaccag ttgacaactc catggacagc aatatccatc aaaggcgaaa   3780
 ttcatacaga gggcatgagt cagaggacag catgtctaca ctggctggaa ggcgaggaat   3840
 gagaccaaaa atgatgatgc cctttgactc ccagccaccc cagcctgtga ttagtgccca   3900
 tcccatccat tccctcgata accctcacca tcatttccac tccagcagcc tcgcttctcc   3960
 agctcgcagt catctctacc acccgggcag cccatggccc attggcacat ccatgtccct   4020
 ttcagacagg gccaattcca cagaatccgt tcgaaatacc cccaggcact ggacaccatg   4080
 ccagcctctt cgtctcaaac atgctgcact gatcaccagg accctgaagg tgctaccagc   4140
 tcctcttact tggccagctc ccaagaggaa gattcaggcc agagtcttcc cactgcccat   4200
 gttcgccctt cccacccatt gaagagcttc gccgtgccag caatcccgcc tccaggacct   4260
 cccacctatg atcctgcatt gccaagcaca ccattactgt cccagcaagc tctgaaccat   4320
 cacattcact cagtgaagac agcctccatc gggactctag gaaggagccg gcctcctatg   4380
 ccagtggttg ttcccagtgc ccctgaagtg caggagacca caaggatgtt ggaagactcc   4440
 gagagtagct atgaaccaga tgagctgacc aaagagatgg cccacctgga aggactaatg   4500
 aaggacctaa acgctatcac aacagcatga cgaccttcac caggacctga cttcaaacct   4560
 gagtctggaa gtcttggaac ttaacccttg aaaacaagga attgtacaga gtacgagagg   4620
 acagcacttg agaacacaga atgagccagc                                    4650



      <210> 2425
      <211> 434
      <212> DNA
      <213> Homo sapiens


      <400> 2425
 ggaattcctc gggaggccta cctgctggag cacagccaca atgggggacc agttcattat     60
 gctgagctgc gagtggcctg gcggcgagcc ccctgccacg ctgggctggc ttgacgaaca    120
 gcagcagccc ctgggcggca gcagctcctc gatggccgtt cacctcctgc aggcccaaga    180
 agatctggct ggcagagagt tcacctgccg gggcactcac ctgctcagga cccctgaccc    240
 ccactgccac ctccagctgg cggacccccc cttcagcgcc tacccagcgg tgttgggtgc    300
 agcaggcacg ggaatggtgg tagcaacggt ggcctctcta ctggtgttcc agtatgctgc    360
 ccggcaccca gagactttcc cccgccttgg tcaattgctt gttcccacgg agcaaaggca    420
 ccaacagagg ggtt                                                      434



      <210> 2426
      <211> 1012
      <212> DNA
      <213> Homo sapiens


      <400> 2426
 atggccatga gagtgacctc tggtcgtcct cactgctaca ctcccaccag cgccatgaca     60
 gtttacaaat gccacggacc caaggttccg atccgcgcca aggcgttccg gtcagcagca    120
 gccccgcggc tcctcgggcc ccgccgcgct ggcaagcccc agtccccgcc agcccaatcg    180
 tgctggcgct ttaaggacgg gcggggcggg ctgggcgaca gcgctggaca cctggagctg    240
 cccgaggacg cggaggagag atgtgtgacg ggagccactt ggcctccacc ctccgctatt    300
 gcatgacagt cagcggcaca gtggttctgg tggccgggac gctctgcttc gcttggtgga    360
 gcgaagggga tgcaaccgcc cagcctggcc agctggcccc acccacggag tatccggtgc    420
 ctgagggccc cagccccctg ctcaggtccg tcagcttcgt ctgctgcggt gcaggtggcc    480
 tgctgctgct cattggcctg ctgtggtccg tcaaggccag catcccaggg ccacctcgat    540
 gggaccccta tcacctctcc agagacctgt actacctcac tgtggagtcc tcagagaagg    600
 agagctgcag gacccccaaa gtggttgaca tccccgacta acgaggaagc cgtgagcttc    660
 ccagtggccg aggggccccc aacaccacct gcatacccta cggaggaagc cctggagcca    720
 agtggatcga gggatgccct gctcagcacc cagcccgcct ggcctccacc cagctatgag    780
 agcatcagcc ttgctcttga tgccgtttct gcagagacga caccgagtgc cacacgctcc    840
 tgctcaggcc tggttcagac tgcacgggga agaaagtaaa ggcttcctag caggtcctga    900
 aaccaaaaga caaaaaaggc tgtgcccttc tcccaaaacc ttaggccggg cgctgggaca    960
 acaggaggcc cttcctgcaa acgttcgttg gtgaaaggct ggtcatattt aa           1012



      <210> 2427
      <211> 2394
      <212> DNA
      <213> Homo sapiens


      <400> 2427
 tcattcctta gtgccccgct tattggtgct ctttctgatg tttggggccg aaaatccttc     60
 ttgctgctaa cggtgttttt cacatgtgcc ccaattcctt taatgaagat cagcccatgg    120
 tggtactttg ctgttatctc tgtttctggg gtttttgcag tgactttttc tgtggtattt    180
 gcatacgtag cagatataac ccaagagcat gaaagaagta tggcttatgg actggtttca    240
 gcaacatttg ctgcaagttt agtcaccagt cctgcaattg gagcttatct tggacgagta    300
 tatggggaca gcttggtggt ggtcttagct acagcaatag ctttgctaga tatttgtttt    360
 atccttgttg ctgtgccaga gtcgttgcct gagaaaatgc ggccagcatc ctggggagca    420
 cccatttcct gggaacaagc tgaccctttt gcgtccttaa aaaaagtcgg ccaagattcc    480
 atagtgctgc tgatctgcat tacagtgttt ctctcctacc taccggaggc aggccaatat    540
 tccagctttt ttttatacct cagacagata atgaaatttt caccagaaag tgttgcagcg    600
 tttatagcag tccttggcat tctttccatt attgcacaga ccatagtctt gagtttactt    660
 atgaggtcaa ttggaaataa gaacaccatt ttactgggtc taggatttca aatattacag    720
 ttggcatggt atggctttgg ttcaaaacct tggatgatgt gggctgctgg ggcagtagca    780
 gccatgtcta gcatcacctt tcctgctgtc agtgcacttg tttcacgaac tgctgatgct    840
 gatcaacagg gtgtcgttca aggaatgata acaggaattc gaggattatg caatggtctg    900
 ggaccggccc tctatggatt cattttctac atattccatg tggaacttaa agaactgcca    960
 ataacaggaa cagacttggg aacaaacaca agccctcagc accactttga acagaattcc   1020
 atcatccctg gccctccctt cctatttgga gcctgttcag tactgctggc tctgcttgtt   1080
 gccttgttta ttccggaaca taccaattta agcttaaggt ccagcagttg gagaaagcac   1140
 tgtggcagtc acagccatcc tcataataca caagcgccag gagaggccaa agaaccttta   1200
 ctccaggaca caaatgtgtg acgactgaaa tcaggaagat ttttctatca gcacccaggt   1260
 cttagttttc acctctagtt ctggatgtac attccatttc catccacagt gtactttaag   1320
 attgtcttaa gaaatgtatc tgcatgaact ccgtgggaac taaaggaagt gggaacttag   1380
 aaccagacag ttttccaaag atgttacaat ttcttttgaa aaaccttttg tttattagca   1440
 ccaatttctc gccactaagc tatttgtttt attatacatc ctttaattaa aaactatata   1500
 tgtaacttct tagatattag caaatgtctc tgctaccatt tccttaaggt gttgagcttt   1560
 aactctatgc tgactcagtg agacacagta ggtagtatgg ttgtggacct atttgtttta   1620
 acattgtaaa attttgagtc agattttaat attgtaaaat cttgggtcaa ataattcaaa   1680
 gccttaatgc agatgcacta aaacaaagaa atggtaaatg aattgtttgc atttaaaaaa   1740
 aaaaactctt aagaaaactg tactaaatct gaatcatgtt ttgagcttgt ttgcagtact   1800
 tttaaacatt attcactact gtttttgaag tgagaaagta tcagccattt agcatttaag   1860
 ttggggtatt tagagcctgt aatctaaatg ctggctcaaa tttattcccc agctacttct   1920
 tataccacta ttcttttaat gtttgcataa tcataagcac ctcaacactt gaatacataa   1980
 tctaaaaatt atatagtaaa gctggtagcc ttgaaaatgt cagtgtgata tctattatgt   2040
 agataaatat atatagtggc ctttcaggac tgtcacagta acactttatt tacagagcta   2100
 atgtttgtcc taaattttca ggaccctaga ggagagcttt atacaattac cgatgtgaat   2160
 ttctctaaag tgtatatttt tgtgtccagt tatattattt aaaaaagtgt tactttgtaa   2220
 aaattgtata taaagaactg tatagtttac actgttttca tcttgtgtgt ggttattgct   2280
 taatgctttt taaacttgga acactcacta tggttaaata aaggaattaa aagaaatgaa   2340
 aatattaagt taataaagtt aaatatttta atgatttttt ttttaaaaaa aaaa         2394



      <210> 2428
      <211> 882
      <212> DNA
      <213> Homo sapiens


      <400> 2428
 gggggatgcc agcatttaca tcatagcggg atagacggtt tcaaatgtat tttagtaaag     60
 aacttacagc ctcatgtcat agaggctctg gaagtgccaa gtatttggtg agaatgacaa    120
 acctgcatag accaaaaagg tgatgagtgc agccagcagg tggatacgaa gcttggttcg    180
 gacttcctgg aagtgcagca gagcgctgtg gaagagaaag gagcagacgg cctctgtgat    240
 gaccgctttg agcaagtcga ctcggatggg attcttgcaa gcgaagctcc tctcgctgac    300
 gtgatactgg gtcagaccca agctccacaa ggcgcttgtg cagtacctgc tgcacagggc    360
 actaaccagc tgagccaata gcctcaccgc acccgtctcg ggggacatgc cccccagcat    420
 catctgcatc atcacgccgc acgggttgct ggacgtgccc accagagtca ggccatgcac    480
 aagcgagaag aagtagacga gcgtcagcgt ccaggtgggg tgcgcggggt gctgttcgct    540
 cagcagttgc agctcgtggg tgcagcagca gagctggaag gtggctagaa actccaggac    600
 gaaggcgtgg gccaccggcc tgtgcagctg ctgccgggcg actacgcggg ccagccccat    660
 gagcagcacc accgacagca tcagtcccag cgaggtgcag gtgtcctgca gctcggaccg    720
 gagccccagc agcggcgaca tggctccgtc gccgcctgag cgggttgcgg gctccggctc    780
 tgggtaggag gcggtctcca ggcccgagtc cgaagtccgc agcccctccc ctcctcacgc    840
 ccctcggggc gggacgagcg ggaggctccc gagcgaattc ca                       882



      <210> 2429
      <211> 1886
      <212> DNA
      <213> Homo sapiens


      <400> 2429
 tcgtcgcctt tgcctgcccc gccgcctccc ctggctgtgt ggagagaagc agggacgtgg     60
 ccatcgcctg ccatgggcat cgtctgctcc tgaggctgct ccaggtgcct tctggaactg    120
 tcccagtgcg aatcccaccc atgagggccc ggccccaccg gctggcgccc aagacccact    180
 tcccctgaga gccactccca ggccatgttc tggggaaggg gaaggacctg ccgtccctct    240
 gcctgtgccc acacatggcc cactgtgccg cagcggacgt caccacccgc ttcgatgagg    300
 tgttctggtt tggagacttc aacttccgcc tgagtggcgg gcgcacagtc gtggacgccc    360
 tcctgtgcca gggcctggtg gtggacgtgc cggcgctgct gcagcacgac cagctcatcc    420
 gggagatgcg gaaagggtcc atcttcaagg gcttccagga gccggacatc cacttcctcc    480
 catcatacaa gtttgacatc gggaaggaca cgtacgacag cacctccaag cagaggacgc    540
 cctcatacac ggaccgcgtc ttgtacagaa gccgccacaa gggtgacatc tgtcctgtga    600
 gctactcttc ctgccccggg atcaagacgt ccgaccaccg ccctgtgtat ggcctcttcc    660
 gggtgaaagt gaggccgggg cgagacaaca ttccgttggc agctggcaaa tttgatagag    720
 aactgtactt actaggaatt aaaagacgga tttcgaagga gattcagagg cagcaagcac    780
 tacagagtca gaactccagc accatctgct ccgtttcttg aagtttgctg aacgaggact    840
 cacagctgca acgtggggtg attgtattga tcaaaaccca ctgggaagga caaagagttt    900
 gccgcctttc ggggatccga gggactgtgg cgaccgtgcc tctgtgccag cgtcccagga    960
 aggaagccaa ccctgagcga gcctgtcctc tgtggcaggt ccacacggtg tgggtgggca   1020
 gggcttggac ccccgtctcc atggcaggtc catacagcat gggtggcagg gtttggaccc   1080
 gcccagcagc accacggacc ccagccactc tcgggggcag acgtcagaat ccgttcctga   1140
 gcagctcccg tgccctgggg gcagtcacag agccccccaa cacccccgtg ctctgcacca   1200
 gcctctccct ccacacccga agcaggcgtc catctgtgtc ctcctggcag cccctcaaac   1260
 acacaccacc ccatgtcaca cgggtatcca gagcaaggct ggatctgggc taggtgaccc   1320
 ctggggcctc agacctctga gtgggcccca gagcccagct gaggaagcca cacagcctcc   1380
 aggacgtggc acggttcccc tccacttggc tgcaagtcgc ctgccatggg gcgaggaggc   1440
 ctgcacccca gtataagggc ctccccagct gagtaagaag ctgcttcccc tcctctcata   1500
 ggccaagcct attgtgtgaa accgtctcat ggtcttggtg acgtagacca tttttgaaac   1560
 cgtctcatgg tcttggtgac gtagaccgtt tgcttcttta actccagccg cggaatgaca   1620
 ttagtggaac cgggctgggg aactgctgga agttcaggat gccaccacct tgaacaccta   1680
 ggccagggat ccccaccatg tcccgggttt ctttcttcga gagtatagaa ccgttcattc   1740
 ttgctttgtg tcccattcca tctcttgaaa aaatgtagtc tttgaatgtg tgaaaatcta   1800
 gggacattca atctagtctt ttaaattatt tttccatatt tatattttta aataaatgca   1860
 tatattgagt cttaaaaaaa aaaaaa                                        1886



      <210> 2430
      <211> 2144
      <212> DNA
      <213> Homo sapiens


      <400> 2430
 tttttttttt ttaaattaac cagatctgtc ttttaatagt taccagaatt tagatgttaa     60
 ttccccagag gaaaaatgtc catggcacag tttttctgga aaagttcaca tgtagacagt    120
 gaagcttctg aagttaggcg tcaaattagt agtgacaatc ttttttttaa tcttgaaagt    180
 ccctagtttt aaagaaagta gaatccatct ggggcatgtc tgcatcacag ggtatcactc    240
 aagagtcatc atcaggccaa aaagactctg aagggaacca ggagggtttg gcccttgctg    300
 tggaaagatg ctactgaaag tataagagaa caccctaatg cacgcgtcag gcacgaaacc    360
 gtaccatgcc ccgctaagac atgggaccag agaacacgtc aacgtcaggc cgctccagga    420
 aaaccatcca caaagacaac agaagctaac ccgaggtcga cactgccatg aagagtgttg    480
 gctgaaaccg cagttaccag tgtctttact ggacgcgaac atccctaagg acacggctgt    540
 gctgcttcct aagcatacgt gaccacgata ctgtctttcc ccgggtctcc ttagcgccat    600
 cactgcacca ggcccagcat gcctcaagtc ctccagagcc ttctcctgag acagcactag    660
 gggccacgtc agaccccagg ctgcagccct tcaccgtgcc cgtccccggt ccggtctgcc    720
 ctgctggggc cggtgggtat catggggacc cctgtgtaga cacggacacc ggagagcgtg    780
 ggacaggagg cgtctcagag ctccccaccc acacactcaa gggtcagcgt cactcatgtt    840
 tccttctgtt cccatggtgc ctccaaaagg gtttccaaac aaagtcatca ttgattaccc    900
 tggagtatgt caataagcca aacaccagca gccagatacc accaagctag tcaccacttt    960
 aaaagaagat gagctggaga acgaagcagc cctctgatgg acccagtcag tgcagtcggg   1020
 actcagggag acacccgggg acccctgccc agctccctgc cggaggaaag actagggaag   1080
 ggaagcagag gaggaacgaa gggcgccggc agagagagta acaagtagaa acttcgccga   1140
 tctgggagca ggccgagaaa ctctgttgag ctgctaaaga attcttcatt ctcatgtgat   1200
 tttcttcatt tctgtcttcc cagttactac caaggagcta aggaaagttc aggaatactt   1260
 tgtttagtgt cgccataaca tctccaacca tgcattaagt ttaaccaaaa gctgcaatat   1320
 tccagattct taaattctca atggcaacca atttatgctc aagttgaaaa tctggcaagc   1380
 accgtacgcc ttcagcacac gcgtgggtcc ggattttccc atcacacaca cgctctcccc   1440
 cgtccaaggt gcctgtttac ttctggtctg cgcgggctca ggtttcaaag agcttgctga   1500
 aggcggcccc cacctcggcg atcatgtcgg aggtggtggt ggagcgaccg tgcttctgga   1560
 aggcttggtg gttgcactgc ctggtgagag agcaggcgcc aaacgcggcc accaggagag   1620
 ggctggaccc atttgttttc tgtggtccag caaggagcgc ccagtgtacc aggacgccca   1680
 gggagcccga caggaggtcc ccttgccctc cacacctgcg gctgctgcct tcctggctgc   1740
 acacaagcac ctgctggccg ttggagagga tgtcgcgctc tcctttctgg accaccgtca   1800
 cgttgcccag ggcttggctg agtcttagca cagatccatg gctgtcatcg ctgtccatag   1860
 ggcctctgag ctatgacaac acaggaagac agagaaaaag caaagtcttc ctcagacaca   1920
 cgacgacaga tagccctgtc ccatccgcca tgagactcat gctctcgtgt ctaaagggat   1980
 cacccaggca cctgttaaag gccatgtagg tgggaggatg cccaggatat cacctgcagt   2040
 gagtcctccg agcaggtgct gacacggtgc ctgctccagt gcccatcctc tacctcatca   2100
 gagcaggctg aaggagggaa ttccaccacg ctggactaaa agaa                    2144



      <210> 2431
      <211> 1188
      <212> DNA
      <213> Homo sapiens


      <400> 2431
 atgcttcctg ccccttccct ggtagtgggt gtggaggggg tgactgccca gcttctgcag     60
 cgccagcgac ttcctccacc ttgttcccgc cctgcagggt ctgagcacct ccctcatgca    120
 gacagagccc cggctcccat gttcaccatg ctgagaaaga cctgcggggg acagcaggag    180
 gacagccggg gaatgggccc gcacttgccc aggaggctgg ctgctggctg gttcctcttc    240
 cagaagtccg tgcagatcct gtcctctggc tttgccttgc ctaagaccca gtctgcacca    300
 aggctgagtc cctggacttc tggagagaga gggctgtccc tttgtgccct acaagtacag    360
 tgtgtgggcg cctcccctgg gccctgcaca ggttctgtgg caccggcagc atgcgggaag    420
 aggcagagct cgtgcatgcc cgacctcgct cctcacggct ccctgggcag cagcgccctg    480
 gcagttggaa ctggaaggct tatcagagtc cacgcagccc caccgccctc cccactctcg    540
 gggtcagttg tgtccaacaa tttagctgct acaacccagg tagcaaaagt caagctaaaa    600
 ttccaggctg ccttccccaa cccagaaatt gaaaacaaac ttgcaaaatg tgagcccagc    660
 agagcaagat ctacagcact gacccagatg actgatgacc cgacatcctc aagcccagct    720
 tcagggccca ctacaaggcc ctactactgc ttcactgccc caagcccacc tgtggaattg    780
 aacatagagt ttatcctaaa cggagtcacc tggatcagcg cctgggcttt tattggtgtt    840
 ttgtctgcaa tgggctttgg ccacgtaaat gtgaacaaaa tgagcatacg agttgaatgg    900
 atcacagcat ttactattgc tgctgggaga gctgcaactg gttatctagc ttacaaaaga    960
 ttttatgaca aagatcatca gaataaagct atgatgaacc ttcacatcca gaaagacaac   1020
 cccaagatag tacatgcttt tgacatggag gatttggaag ataaagctgt gtactgccat   1080
 tgctggaggt ataaaaagtt cccattctgt gatgggtctc acacaaaaca caacgaacag   1140
 actggagaca acgtgggacc tctgatcatc gagaaaaaag aaacttaa                1188



      <210> 2432
      <211> 9486
      <212> DNA
      <213> Homo sapiens


      <400> 2432
 cggaccgtgc tttcgccgcc tgggagccgt ccggcgcagc agtttctagg tccccactgt     60
 ccccgccgtc ccgccccttc gcgtcccggg aaccggttgg cttccgagcc gcactcgccg    120
 atcctccagg catgccccgc tacgagctgg ctttaatcct gaaagccatg cagcggggtt    180
 ggtacagtag gcttcactag acttagctgc aactcagaat ttctcctcca gcacctgagt    240
 aaatgctgat ggtcttgtgg agagtggatt aagagtacga gctaagttct caatcccaat    300
 taagaagcgg aaaatttaaa ctgtcttctt caaagtttat cacaaccacc accatcaaga    360
 cagcaaacca aaggacaaag actttgaccc tgctgtgttg ctctgtgtag tccagttcac    420
 gtatggttta cagacttggc tggggttact aaaaataaat aaaaagttgg acacttctgt    480
 cattggagcg ctattattca caagttacca gaatgagagc tgtactggac acagcagaca    540
 ttgccatagt ggccctgtat tttatcctgg tcatgtgcat tggttttttt gccatgtgga    600
 aatctaatag aagcaccgtg agtggatact tcctggcggg gcgctctatg acctgggtaa    660
 caattggtgc ctctctgttt gtgagcaata ttgggagtga gcacttcatt gggctggcag    720
 gatctggagc tgcaagtgga tttgcagtgg gcgcatggga attcaatgcc ttactgcttt    780
 tacaacttct gggatgggtt ttcatcccaa tttacatccg gtcaggggta tataccatgc    840
 ctgaatactt gtccaagcga tttggtggcc ataggattca ggtctatttt gcagccttgt    900
 ctctgattct ctatattttc accaagctct cggtggatct gtattcgggt gcccttttta    960
 tccaggagtc tttgggttgg aatctttatg tgtctgtcat cctgctcatt ggcatgactg   1020
 ctttgctgac tgtcaccgga ggccttgttg cagtgatcta cacagacact ctgcaggctc   1080
 tgctcatgat cattggggca cttacactta tgattattag cataatggag attggcgggt   1140
 ttgaggaagt taagagaagg tacatgttgg cctcacccga tgtcacttcc atcttattga   1200
 catacaacct ttccaacaca aattcttgta atgtctcccc taagaaagaa gccctgaaaa   1260
 tgctgcggaa tccaacagat gaagatgttc cttggcctgg attcattctt gggcagaccc   1320
 cagcttcagt atggtactgg tgtgctgacc aagtcatcgt gcagagggtc cttgcagcca   1380
 aaaacattgc tcatgccaaa ggctctactc ttatggctgg cttcttaaag ctcctgccaa   1440
 tgtttatcat agttgtccca ggaatgattt ccaggatact gtttactgat gatatagctt   1500
 gcatcaaccc agagcactgc atgctggtgt gtggaagcag agctggttgc tccaatattg   1560
 cttacccacg cctggtgatg aagctggttc ctgtgggcct tcggggttta atgatggcag   1620
 tgatgattgc agctctgatg agtgacttag actctatctt taacagtgcc agtaccatat   1680
 tcaccctcga tgtgtacaaa cttatccgca agagcgcaag ctcccgggag ttaatgattg   1740
 tggggaggat atttgtggca tttatggtgg tgatcagcat agcatgggtg ccaatcatcg   1800
 tggagatgca aggaggccag atgtaccttt acattcagga ggtagcagat tacctgacac   1860
 ccccagtggc agccttgttc ctgctggcaa ttttctggaa gcgctgcaat gaacaagggg   1920
 ctttctatgg tggaatggct ggctttgttc ttggagcagt ccgtttgata ctggcctttg   1980
 cctaccgtgc cccagaatgt gaccaacctg ataataggcc gggcttcatc aaagacatcc   2040
 attatatgta tgtggccaca ggattgtttt gggtcacggg actcattact gtaattgtga   2100
 gccttctcac accacctccc acaaaggaac agattcgaac caccaccttt tggtctaaga   2160
 agaacctggt ggtgaaggag aactgctccc caaaagagga accataccaa atgcaagaaa   2220
 agagcattct gagatgcagt gagaataatg agaccatcaa ccacatcatt cccaacggga   2280
 aatctgaaga cagcattaag ggccttcagc ctgaagatgt taatctgttg gtaacctgca   2340
 gagaggaggg caacccagtg gcatccttag gtcattcaga ggcagaaaca ccagttgacg   2400
 cttactccaa tgggcaagca gctctcatgg gtgagaaaga gagaaagaaa gaaacggatg   2460
 atggaggtcg gtactggaag ttcatagact ggttttgtgg ctttaaaagt aagagcctca   2520
 gcaagaggag tctcagagac ctgatggaag aggaggctgt ttgtttacag atgctagaag   2580
 agactcggca agttaaagta atactaaata ttggactttt tgctgtgtgt tcacttggaa   2640
 ttttcatgtt tgtttatttc tccttatgaa cttaaggata tggtgagaca ctaacttaag   2700
 acaatactga ctggtctttg gggaaaaaag ttatgtaact gtgcatctct caggcattgt   2760
 ttacgctgta ggttttagcc aaattttact tagcagaaaa tcatctaatt acaagacttt   2820
 attttcccag agatggatta aagtaaatct tcaacttaag tgaagccaaa cctaacagac   2880
 tgaattgtgc aaatgtggtt ttaaattttg cataccaaag taagaagaga ccaattattc   2940
 tcacagagca cttagagcag aatatatgtt aagttaccat gaattaaggt atactgtctg   3000
 cactgccaag tcttggcaga ccttaccctg aagtagaaga tttgctcatt tctaaagttt   3060
 tttttctgtc tctgtaatcc ctcctaccat taagaaaaac ttatttctta gacattgtac   3120
 aatcagttat gtactgaaaa tcgaatgtgc ttgtgtgata cttgtttcag gacaagttca   3180
 tttgccaggt tcattttgtt agcatgagcc tacggattct gatttcccaa agaaagaatg   3240
 ttttcctgta ggtatttttg taccaccagt atatggaatg ttagggaaaa actttgttcc   3300
 agttcctttt tttttttctt tctactttca agtttaagtg aaccatactg aaatgaccaa   3360
 caagtctgcc tgtaaagtta catgtcatga ttgtgttgtt aaatgattat gggggagaaa   3420
 atgaagtaaa tgttgctgat gatccccata tttattgatc atattaaggt tgtttatata   3480
 gtttggaaat gaccagcccc ctaagcagtg tttgattaac ttatgctaat cagatgatta   3540
 ctcatatatt ctgctaattt tctagcttta ttcttgttat ttggaaaaat tattagccaa   3600
 atgccttcct aggtggatcc agttggaaga tatgtccaga aacctgaaga aaaattgacg   3660
 ctgcctttgt gtgctggatt gctctacttg attagatcat gatatatcaa ggttgaattt   3720
 ttagagggaa aatttaattc tgatatctta ttgcatcctt gataagtttt tccctgattt   3780
 ttttttcctc caaagacttt ccatctggac acagcctcca catttttgtt gtagtgactt   3840
 agagcataag gatgtttcag tgccaattcc ggccgtcggt aacagaaaac tcagtgcata   3900
 ctttgctgtt gttaggttgt caatatagtc tttctgtagg atggatagca tgtttgagag   3960
 gtgccaaaca agaacttttg gggttagtag tgtgtcttgt ggagggtatt acaggactgt   4020
 gtaattatag gactctaact tgacatggct tggcacccac ttgcagctag tgggtacagg   4080
 gtacaaaaga tgttagagaa aagctctaca gattacgtac ttctgtgtct tcgtatgctc   4140
 aacactgtcc tttgtcctcc atgaaagatg aaggaagcaa attatgtatg tactttcttt   4200
 gaccttcttt aatctctgat actttttaga ttgcatgatt ttactaggct tgtatttagg   4260
 gaaattactt tcataaatac ttttgtagat tttgaatcaa aactcagtct ttttaatttt   4320
 tttgtagtct ataaactagt ttcattatga tggacttgat tagtccaaag ttaattttag   4380
 aaattgtcag gtagcatagt gtcttcccat gatcaggagg ctttctgaag gactgagtct   4440
 gtaaatgaaa aaataattta tgtatgaata gcatgtattt ctgaagagct tagagtgcct   4500
 cgtagaattt ttctcaattt tattcttgag gtttataatt tgggggccaa atagatagag   4560
 ctcatcattt tcttgtttgg aagttgaggc tgcgacatgt ccaaggttat gaagtctctt   4620
 ttgggaagaa cagaaaccag gtctccaaat ctggactcat ggtttgttca gatgtgtctg   4680
 gacaaatggt tgtcaatgtt ttgtcctgtt ttttcaaagg aactgttctt cctttgggac   4740
 aaccttttgg tgtttgggaa agtaataaga tcttggattt ttcaaattaa cattaagttg   4800
 taagaactaa aattttcttt gaaccacact actgtgtaat tcactgataa ttgacatatt   4860
 ggctgggcag cctatctctt ccatatccag cgtaaatgaa taggaggtgt ctgtgatttt   4920
 ttttttctcc ctttatttaa cattgagtcc tagtagtttg gagaattagg gtccctctac   4980
 cttctttctg ctcttgtctt agtaagatac ataaggtaca tcatcttgtg tctgtgtgta   5040
 tatagcagta ggtcaagttt agagtactaa agtctgtaaa taaggaatga ctattagcat   5100
 attcattaga attgtttatt cttgccagta taaacatcat tttatttaga ctaaagtccc   5160
 tgaagcttgt ctttcttatt gctttccagt aaatagataa tgtgctcgag taagtttgtg   5220
 aattgctgat tgcaacttaa ttcagggacc agtcttcaat ctatatttca ttagaatgat   5280
 tgtccctgga atgatcatac atggactgtc ttaagctagc aaaatgttca tactttacac   5340
 tgactaaatg ggtcctaaat gatgacattg gtctttagac attaacatgt gtatattttt   5400
 atattagctc aagctaaggt tcagaattga agcttgatat tgactagaat agctaaaagt   5460
 caaaatgagg tgaggacact ggtcttggaa ggtagagaaa aataaatgtc ttaccaggtg   5520
 ttaatggtat ccccagttct tagacttttg tcttctcagg caattttcat ctcaagatct   5580
 gatgagaagg gcatattaca ttggtatgca ggatgattat tgcatatttt gtgggacctc   5640
 taatttccct ggtcatcttt cagaatattc tgttctgcca cccccagaga gtaaacactt   5700
 gagccgattt cttcttcccc agctattctt tcctgggggt aattatgctt tgtctttaga   5760
 ttagagaagc atcaagcaat agcaatggtg ctgtgtcctt cggcctaaat tcaatagatc   5820
 tcatctccta gggcttcctt ttcacttggc tcaaaggatc cattgtattt tggcacaaag   5880
 agcctggcca gggtcatgta gccatagctc ttagggatga tacctcaaga aattagctgg   5940
 gacccatcac tctgtgaaac ttcacatttt aagaactgag ttgagggggt tgttatgcac   6000
 ttctgtaact tgaggctaag caaggggtta actcttgtga gagccaatag agtgtgtctg   6060
 tattcgcagt ccatggctca ttttctttat agtaggcata tggatcttcc cctctgactt   6120
 tgaatatcat ttggtgtggc ctgtgggtta ttttcattct ttaccaccaa ataaagcggc   6180
 ttattagcta ctcagttact tgctactcaa aggttaggtc ttccctgttc ctgcttggca   6240
 gtgttaaagc ttacagggtt aacttatgat gattctcctg gctcattttc atcagaggca   6300
 tgatgactgg aaagggatca catgggtcgt tggtggtgac acctcactgt ttcctaggtt   6360
 tggatagaga gatgtataca agacctttcc tgttaaatta cgtgactaca gagacttgcc   6420
 aggacaaaat ttcctaagaa atcagaaaaa tgattaagtg agataagtac ctgggtgaca   6480
 cagatattag cccgttggta aaagacaaca aatattagct taaaatctgc atatgtagaa   6540
 tcattttcat tagatttaga gcttgaagca ccttggctct cagctacttt aaactcctcc   6600
 ccatataaat cagggcacca ataaataagt ttcagctttt taaaccctgg tttgatgtta   6660
 agcattataa agtacgaagt ttgttaccac agtagagata atttagtaga aaaatgcttt   6720
 gaggcttcag tatttgtaag attttgcatt agccagatgc taggttgttg aaggcatttc   6780
 agtgttgata atagcctgag cagacttctt tacaaatggg atctgtttct atatgtgtat   6840
 atgcccactt accattcaga gagactggtc tttctctttg tctcccttca cattgctgtg   6900
 tcagtcctac acctagtctt ttcagcactt agcaaattca aatttggatt ttttggtcag   6960
 cttagttcac tttaaggcat attggcatgg tgtgtgaaag tgatgtttgg ccccagtatt   7020
 gaggactttt agatccaaat aatgactcat taaatataat tatgttttaa gtatactgaa   7080
 tttctgttag cttaaaatgt taatcctcag gaatgatttc ctcacacttt gtgttggcta   7140
 ataataaaag cactgtttta tcctcaaaac tcctttttca aaaattaggg agagagcagt   7200
 agtgatcatt tatgtgagcc cctttgaaat gatggtgtca gagtgcagag aaacaatgga   7260
 gttttgatgc caaaaaggtt tttttgcagt aaaagtaaaa atttggaatt agttggcata   7320
 taaaggaacc cttttgtact ggaacgtatg aggctggatt gtgaaaaggt aatctttcga   7380
 ttgctagact tggttaactt agggctgcaa atctttttct tctatcaagg tcacttaata   7440
 tggaatgttt ttgtcagact gtcctttgtt ggaatacttt agctgttcag ctactttgac   7500
 tcctaggaga gaatttagtt aaggttcaaa gtaattaact ggctttgcca gtggtgagtc   7560
 ccacaccatt attcacttag tagtcatata aatgttttta tttactctct tcaatgctga   7620
 gaataaggct ttaaattact gattcacctt taaaggaatg ttgtgagaat tgatgtaatt   7680
 tctgtttctg tttccatcta aacttcttta taaaaagagg gattagtttt tttgttttgg   7740
 ggtaagcacc taatttatcc agtaaccaac aaccctaacc attggcatat atagtctttc   7800
 actcagaaat aaacaaaaac tgtttggtat atctgtatca ttgctaatct tgtgcacttt   7860
 actttttggg cagtaccata catagtctga ggctattgac ttaaaccaat aactgtactt   7920
 tatgtaatga ctcttaaatt tggttacctg ggttcacagc ttgcttgaag agaaaggatg   7980
 ctagaataaa gtaagcagct gaagagcgag caaatcaaga caaaacacag tggtctcaga   8040
 tttttcgtag tgtgggaaca gtggttttgc tctataccac tgaaaagcac tataacataa   8100
 ttgttgtcca tgatactgaa gcttttcccc tcacttctag gttgtttaca ttcagagctc   8160
 tatcaataag aggaatacat attacagtga attcgacaac cgcacaagtt ggcagtaggt   8220
 atccccaacc taatttatct tggtaaattc accctgtttc ctagtgctgc tggataaaag   8280
 agtgtttact ttttattgct cttagacaga gtagtctaga taagttttca atttatcaac   8340
 atagcctaga cttctgtaag tggaatgttc attagtaact catctttttg ttgttataat   8400
 tggaaacaga aacgaggctt attgctattg cagaaatccc aaactggcaa aggccagtat   8460
 atatggtatt ccataatata accagctttt gaaatttatg tgtttggatt agtgccttct   8520
 ggttaccagt attgactctg ctagtttgca cctttccgtt cttaacagaa aatttgtatt   8580
 tgttattcct cttaaatttt gtcgtaacta gtgaaggaag taaaaaaaaa aaaaaaaaca   8640
 tgcattacat tgacatactt tatgtgcagc ctttatttag gttcagtgaa accaggtagt   8700
 tctgtatttg tgttgtagcc taaatgttgt ttcttttata tccattaaaa acttaaagtt   8760
 acttatgttc tgtgatctta attttgttgt gtttccattg taggttgata ggtatatcga   8820
 gaacaggtac gtgacaacag tttatattcc atgatagaaa gctaaagtcc atagaaagca   8880
 caaaatcgtg ttcacacatt agtgtaccca cacatagaaa gcacaagact aatagtattc   8940
 tctgtatccc acaagtgcca gtcataaagg ccaccaggta tttgtctcag agttgctatg   9000
 agcactacag tattgataag cccaagacaa tgcggtatct aaactggtcc taatggtaag   9060
 ggacccaaag gaataatctc aataagtttg taccacattg atggagggag agaatacaaa   9120
 tgtcaagaat gccaaaatta tatttggggg ttactagcta aaatggggtt tgagggcttt   9180
 ttactgcaac ttgaaactgg agaaataggg acagatgtct aggtttttgg tgggtggaac   9240
 aggtgacata tttctgtttt aagctgtagt gtgattgggg ttttttgtaa aaaatcttaa   9300
 atcttttagg aaatattacc tcttaacagt gcccccccaa acatgcagaa agtcatactt   9360
 taacagggca aatactactt gtctttgatt ttttttgtgt acgtttgtat gtgagagatg   9420
 aagttacctt tatttttttc ctatacttga ctgtgcttca ttttaataaa ggataatttg   9480
 atctga                                                              9486



      <210> 2433
      <211> 421
      <212> DNA
      <213> Homo sapiens


      <400> 2433
 cggtggcatt cgccttccac ctcctggatg tggcagataa cgcccttcag acactagagg     60
 aaacagcttt cccttctcca gacaaactgg tcaccttgag gctgtctggc taccccctaa    120
 cctgtgactg ccgcctcctc tggctgctcc ggctccgccg ccacctggac tttggcatgt    180
 ccccccctgc ctgtgctggc ccccatcatg tccaggggaa gagcctgaag gagttttcag    240
 acatcctgcc tccagggcac ttcacctgca aaccagccct gatccgaaag tcggggcctc    300
 gatgggtcat tgcagaggag ggcgggcatg cggttttctc ctgctctgga gatggagacc    360
 cagcccccac tgtctcctgg atgaggcctc atggggcttg gctgggcagg gctggacgaa    420
 a                                                                    421



      <210> 2434
      <211> 253
      <212> DNA
      <213> Homo sapiens


      <400> 2434
 atggatgatg ctggaaacca tcattctcag caaactatcc caaggacaga aaaccaaaca     60
 ctgcatgttc tcactcaaag gcctcagtat ggtggcttat tctgtccagg ttctagccgt    120
 atttatcagc tgtgcaatat taacccttgc aatgaaaata gcttggattt tcgggctcaa    180
 cagtgtgcag aatataacag caaacctttc cgtggatggt tctaccagtg gaaaccctat    240
 acaaaagtgg aag                                                       253



      <210> 2435
      <211> 4470
      <212> DNA
      <213> Homo sapiens


      <400> 2435
 atggggctgc tgctcatgat cctggcgtcg gccgtgctgg gttccttcct cacgctcctc     60
 gcccagttct tcctgctgta ccgcagacag cccgagccgc cggcggacga ggccgcccgc    120
 gcgggcgagg gcttccgcta catcaagcca gtgccgggcc tgctcctaag ggagtacctt    180
 tatggcggcg gccgggatga ggagccctcc ggagcggccc ctgagggcgg cgcgaccccc    240
 accgcggccc ccgagacccc cgccccgccg acgcgggaga cttgctactt cctcaacgcc    300
 accatcctat tcctgttccg ggagttgcgg gacaccgcgc tgacccgccg ctgggtcacc    360
 aagaagatca aggtggagtt cgaggagctg ctgcagacca agacggccgg gcgcctgctg    420
 gaggggctga gcctgcggga cgtgttcctg ggcgagacgg tgcccttcat caagaccatc    480
 cggctcgtgc ggccagtcgt gccctcggcc accggggagc ccgatggccc tgaaggggag    540
 gcgctgcccg ccgcctgccc cgaggagctg gccttcgagg cggaggtgga gtacaacggg    600
 ggcttccacc tggccatcga cgtggacctg gtcttcggca agtccgccta cttgtttgtc    660
 aagctgtccc gcgtggtggg aaggctgcgc ttggtcttta cgcgcgtgcc cttcacccac    720
 tggttcttct ccttcgtgga agacccgctg atcgacttcg aggtgcgctc ccagtttgaa    780
 gggcggccca tgccccagct cacctccatc atcgtcaacc agctcaagaa gatcatcaag    840
 cgcaagcaca ccctaccgaa ttacaagatc aggtttaagc cgttttttcc ataccagacc    900
 ttgcaaggat ttgaagaaga tgaagagcat atccatatac aacaatgggc acttactgaa    960
 ggccgtctta aagttacgtt gttagaatgt agcaggttac tcatttttgg atcctatgac   1020
 agagaggcaa atgttcattg cacacttgag ttaagcagta gtgtttggga agaaaaacag   1080
 aggagttcta ttaagacggg tacaatctcc ctcacagctg ttttcatggg ctggcatcga   1140
 gtgtctgagg cttttccagg cttatggtac aagctgttgg tggatcttcc attctggggt   1200
 ctggaggatg gtggccctct tctcacagtt ccacttaggc agtgccctgg ttgaattaat   1260
 aaaaggaaat ttacaaagtg ttggacttac acttcgtctt gtccagtcaa ctgatgggta   1320
 tgctgggcac gtcatcattg aaactgtggc tccaaactcg cctgctgcaa ttgcagatct   1380
 tcagcgggga gatcgactta tcgccattgg aggtgtgaaa atcacatcaa cactgcaagt   1440
 gttgaagctt atcaagcagg ctggtgaccg agtcctggtg tactatgaaa ggcctgttgg   1500
 ccagagtaat caaggtgcag tgctgcaaga taactttggc cagttggaag aaaacttttt   1560
 gtcaagctca tgccaatcgg gttatgaaga ggaagctgcc gggttgacag tagatactga   1620
 aagtagagag ctggattctg aatttgaaga cttggcaagt gatgtcagag cacaaaatga   1680
 gttcaaagat gaggcacaat cattaagtca tagtcccaaa cgtgttccaa caacactttc   1740
 tattaaaccc cttggagcta tatcaccagt tttaaaccgg taaattaggc tggtaggaag   1800
 ttcacccact accaccggaa aatttcagtc caaagatggg aaataaacct ccacccctaa   1860
 aaacttctga gataacagac ccagcacaag tgtcaaaacc aacccaagga tctgctttca   1920
 aaccacctgt gccaccacga ccacaagcga aagttccttt gccttccgcc gatgctccaa   1980
 atcaggcaga accagatgtt ctcgttgaaa agccagagaa ggtggtgcca cctcctcttg   2040
 tagataaatc tgctgaaaag caagcaaaaa atgtggatgc catagacgat gcagctgcac   2100
 ctaagcaatt tttagcaaag caagaagtgg ccaaagatgt cacttcagaa acttcctgcc   2160
 ctactaagga cagttcggac gaccgtcaaa catgggaatc atcagaaatt ctttatcgta   2220
 ataagctagg aaaatggaca agaaccagag catcctgttt gtttgacata gaagcctgtc   2280
 acaggtactt aaacattgca ttgtggtgca gggatccttt caagttggga ggtctcatct   2340
 gtttggggca tgttagttta aaacttgaag atgtggcttt aggatgccta gctacatcaa   2400
 acacggaata cctttccaaa ttgagactgg aagccccctc acctaaggct atagtcacta   2460
 gaaccgcact acgcaatctg agtatgcaaa agggattcaa tgacaaattt tgctatggtg   2520
 acattactat tcacttcaaa tatttgaaag aaggagaatc agaccaccat gtagttacta   2580
 acgtagaaaa agaaaaagaa ccccatttgg ttgaagaagt ttctgttctc cctaaagagg   2640
 agcaatttgt tggacagatg ggtttaacag aaaacaaaca cagttttcag gatactcagt   2700
 tccagaaccc aacatgggtg tgactactgt aagaaaaaag tttggactaa agcagcttcc   2760
 ccagtgttat gtttttgtgg cttatgtttg ccataaaaaa tgtcaagaaa agtgtctagc   2820
 tgagacttct gtttgtggag caactgatag gcgaatagac aggacactga aaaaccttag   2880
 gctggaagga caggaaaccc tcttaggcct gcctcctcgt gttgatgctg aagctagcaa   2940
 gtcagtcaat aaaacaacag gtttgacaag gcatattatc aatactagtt ctcgtttatt   3000
 aaatttgcgt caagtctcta aaactcgcct ttctgaacca ggaaccgatc tcgtagaacc   3060
 ttcaccaaaa cacacaccca acacgtcaga caacgaaggc agtgacacgg aggtctgtgg   3120
 tccaaacagt ccttctaaac ggggaaacag cacaggaata aagttagtga gaaaagaggg   3180
 tggtctggat gacagtgttt tcattgcagt taaagaaatt ggtcgtgatc tgtacagggg   3240
 cttgcctaca gaggaaagga tccagaaact agagttcatg ttggataagc tacagaatga   3300
 aattgatcag gagttggaac acaataattc ccttgttaga gaagaaaaag agacaactga   3360
 tacaaggaaa aaatcacttc tttctgctgc cttagctaaa tcaggtgaaa ggctacaagc   3420
 tctaacactt cttatgattc actacagagc aggcattgaa gatatagaaa ctttagaaag   3480
 tctgtcttta gaccagcact ccaaaaaaat aagcaagtac acagatgata cagaagaaga   3540
 ccttgataat gaaataagcc aactaataga ctctcagcca ttcagcagca tatcagatga   3600
 cttatttggc ccatccgagt ctgtgtagca gacaggtcta tttaaacttt caaatgaaca   3660
 gggtaaagtt gcatctaaag taccacagat acaaccatgt ttaaatcctc gtatgcactc   3720
 tggcctgctt ctccagttac ttgcttgtgt aagaacaaaa atgagaaagg ttgttttcca   3780
 gtaaaaacat gaccagctta ctaattggtt gttttggatt gcatttatag ctatgctttt   3840
 ttgggtttat actgggaatt tatttttact aaattattta acttttctaa ttatgtaatt   3900
 atgtaagcta gcttttcatg tttatgtatg tatggtgtcc ccttgtgtta ttttttcttc   3960
 cttcttggtt tttgaattag tggttaaata gaaatactgt cctggattcc ttaaaatatt   4020
 ttcatttccc atcatggtta taacaaattt gcctgcatgc ccaaactgac aacagcaatc   4080
 actgagggaa caggttttga atctttcttt tgtgttatga agtttatcgt ctctacttgc   4140
 ttgagatttt tgttattttg ggggtttggg ggtgcttttt gttttgtttt tgccaaatgt   4200
 aacatgaaag cagatgctgc acctttagtc tgttatgctg atttagtaaa aaaaaatttt   4260
 ttacatatat tgcttgcttt cgatgcttct gtgaaacttt tttctaaagc ttttgtgcag   4320
 ctgtatggta aaaatatggt gattaatttg aagagcttac attgaaagac aatgtaatag   4380
 gaaataaatg cagattgcga gtggtcaaga atcttgtaga gaggataaca agacttaatt   4440
 actgaacaac agcaacatag cattttgaag                                    4470



      <210> 2436
      <211> 709
      <212> DNA
      <213> Homo sapiens


      <400> 2436
 ctgacttaca gctcttataa actagtggca atttctgaac ccagccggct ccatctcagc     60
 ttctggtttc taagtccatg tgccaaaggc tgccaggaag gagacgcctt cctgagtcct    120
 ggatctttct tccttctgga aatctttgac tgtgggtagt tatttatttc tgaataagag    180
 cgtccacgca tcatggacct cgcgggactg ctgaagtctc agttcctgtg ccacctggtc    240
 ttctgctacg tctttattgc ctcagggcta atcatcaaca ccattcagct cttcactctc    300
 ctcctctggc ccattaacaa gcagctcttc cggaagatca actgcagact gtcctattgc    360
 atctcaagcc agctggtgat gctgctggag tggtggtcgg gcacggaatg caccatcttc    420
 acggacccgc gcgcctacct caagtatggg aaggaaaatg ccatcgtggt tctcaaccac    480
 aagtttggaa atttgacttt ctgtgtggct ggagcctgtc cgaacgcttt gggctgttag    540
 gggtaagtca aaagtgcatt cccccctgcc tcacacattt ttttggttca gcccccccac    600
 ttgtcttttt gctcctggtc attcagaact tgcagaagaa tcaacagagt ttttacttga    660
 tgaaatggtc ctaataaact gcttttttat tcttgctagg aaaaaaaaa                709



      <210> 2437
      <211> 4090
      <212> DNA
      <213> Homo sapiens


      <400> 2437
 gtggcacaga gaatgacagt ggtggtcctc aaagccagac acttgccgaa gatggatatc     60
 accggtctct caggtaatcc ttatgtcaag gtgaacgtct actacggcag aaagcgcatt    120
 gccaagaaga aaacccatgt gaagaagtgc actttgaacc ccatcttcaa tgaatctttc    180
 atctacgaca tccccactga cctcctgcct gatatcagca tcgagttcct cgttatcgac    240
 ttcgatcgca ccaccaagaa tgaggtggtg gggaggctga tcctgggggc acacagtgtc    300
 acagccagtg gtgctgaaca ctggagagag gtctgcgaga gcccccgcaa gcctgtggcc    360
 aagtggcaca gtctgagcga gtactaatcc tgttcttctc tcctctaatc cccgggggcc    420
 aagctgggga gggatgtgga ggggaaaaag atgacagaga agtggactcc aaacctcatt    480
 ttagttgtag aagaaaattt cttacaaaac aaattccaca aagaacaccc tatatgacca    540
 cagctgcaga tcagttctta gcaatgatgt ttttttttct gctttgcaag gcgctagaat    600
 cttttatttt actttatttt ttttgaggtg gagtttcgct cttgttgccc gggctggagt    660
 gcaatggtga gatctcaact cactgcaacc tctgccctcc aggttcaagg gattctcctc    720
 cctcagcctc ccaagtagct gggattacag gcacccacga gcatgcccgg ctaatttttt    780
 gtattttcag tagagatggg tttcaccatg ttggccaggc tggtctcgaa ttccagacct    840
 caggtgatcc acccgcctcg gcctcccaaa gtgctgggat tacaggtgcg agccaccgtg    900
 cccggcctct ggttttgttt tgtttttttt ttttaatggg ggacaaaaga gagggaaaga    960
 cccctataaa atctatatat aacaatgtaa ccatatactt gcatgtctta atacaaactg   1020
 aagaaattag cctaactgcc aatatcaagt tggcagattt taatccatgg aaattgtgtt   1080
 ttgtgctgaa ttgtatttgc tgattacctg aaattggctt ctttttattg ggcttctctg   1140
 gagaatttct cccactcccc acctctgcag aagaaaattt tgctcttata aaacctcatg   1200
 ttttcatcat tcccatcttt tctttttatt gcctcttata tctctgctct ttgacctcaa   1260
 ggtctagagg tctgcagtaa gccaagaaac aaaggtgggg tggatgaggc aaggtttgca   1320
 ggagaaagag gaattgagaa atggggtatt tttgctatca gctcttctgc tatgaagtag   1380
 taaaaggcag tctataatta actgacagac ctaactgaag cacagagaat acatcagact   1440
 tatgcatcca agacatcaga acttggattt tatcaaactt gatgacttct ctaaaaggag   1500
 ctttggaaac ttcaaattca gctataggat agtaccaatg aacacatcca gctgatccca   1560
 aaagctgttt tcaggtataa ggacaaggag aggagacaag tgacgacagc cattcccctt   1620
 tgcagctatc tactgtagtg acagccattt cttggttgat gggttggaag tcatcagagg   1680
 tttgaagaat tacactggcc tttgtttttc tggaaatgcc gaccatggag atgctttaga   1740
 gtcttctcaa atagcttaga tgttgtaatg aggttagctt tgcttcataa aacaggggcc   1800
 ctcagaagtt ctccttaaat ttttcaataa aaatttagct cttaaaaaaa taacagtgtg   1860
 actgagtgaa tgaagataag ttggattctt tcagagcatt cttttcctca aaacgagctg   1920
 cataattctt ggaatttatg tcttaccaca tggtggaggg atggaggaac tacaggatgc   1980
 aattcttctt ctaccaatgg gcaatagagg ttgagagaga ttcagcatct ttctgggatt   2040
 agaattcaag tctctttact cctacagcag ctgtgtctcc aacgttgaga ctttgcagat   2100
 ggcacagact ccatggataa taggtaaact tggggccggg cgcagtggct cacgcctgta   2160
 atcccagtat tttgggaggc cgaggtggaa agatcgcttg agcccaggag ttcaagacca   2220
 gcctgggcta catgacgaaa ctccatctct atcaaaaata caaaaaatta actaggtgtg   2280
 gtgctgcacg cctgtggtcc cagctattca ggaggctgag gtgggaggat catttgagcc   2340
 cagaggtaga ggctgcagtg agccatgatc atgccactgc actctgggct gggtaacaga   2400
 gtgagatcct gtctcaaaaa ttaattaatt aattaattaa aataaactag gtaaacttgg   2460
 ataggcagta gatatttttg cccacctgag gaggaactca gtcaagctgt tgcttaacag   2520
 cttgatccag ggcgtgaaag gttagttgag actgaagtgt tcacttccat agaagaacat   2580
 cacttttaac cttgctttgg cgaagggagt cggaaagctg agtctctatg gacggggggg   2640
 tgatcttgct ttcagtgttc cctcagcttt tgtggattta aaaccattct gctccccctt   2700
 aaccttttgt ttgatttcag cccatgttct tgacaatgca gagcaattct gagcagtcac   2760
 aaagcctact ctctgttctt gtccctgcca acccccaccc cccataatct gactcacaac   2820
 ttcaccatca gttggggtca taccactagt ctctgtccta taccccatga aatgtaaata   2880
 ctgtatcata agtagaagaa aataattttt gttttctaaa aatgcatttt gagatagttt   2940
 aatgtaaatc tgacaggagc attctgaagc cccattagga aaaaatttaa atggttcctc   3000
 ttcatcgcct taatgtctaa agatcagaaa tcgctgagca aacccgcttt tgtttccttc   3060
 ccagaaacaa tgcaaaacaa caggtggaga tagtctggtc tttgccctgc tgtgtgtgcc   3120
 tctgtagctc ctcctgacaa acgtctggga aaacagcctc accccactct cctctctctt   3180
 ccccatttcc ttgtagcttt attccttgca tctttgggtc tactgagcag tgggtgctga   3240
 ggtgacaggg gaggaaccag ttgttctgta gcctaggaac tgcctcagtg tctttgccag   3300
 aaaaaggcaa agaggcggac agtgcagggc tcctccctcc tacctcaggc ctgatccatc   3360
 gtgcccttga ctttgccgtc tcaaagtttc ttagctgact ttggctttca catttgttct   3420
 ttccagagct aactgataag agtggaggag gaatgccttc tcctaagagt cagttgaaag   3480
 aaagacaaga gagtcacatc ttagcttttg cacaaggcat tcgtggtcag gaataggtta   3540
 gggaatggtc acttctgatt ttccaacagt tgctccttct ctgaagagat cttgattcct   3600
 ttgggaagac aagaattttt cttaataaca aaggtccctt tatgagttat tccttctttc   3660
 agttcatctc actggagcac agccaagatg gacatgttta tggacagtgc tctagatgtg   3720
 aaaacagata gaactggttt gtgggacagg ggcagcttgc tcaggagagg gaataacgca   3780
 ggtccctttt cttggaaggc ttgtactatg gccatgacag tgacattgcc ctcaccatga   3840
 tccctctcca aagtggttgt ctttctttac cttgtgtctt ctcttgtaaa aatgaaactc   3900
 aaaaataaaa taaatgtgtc aaattttgaa aaaaaaagaa aactgaaaaa gctaacatga   3960
 attgtgtgaa attgcataat gctgtaatgc taatctacaa tatgtaatgc tatcttgtat   4020
 gttgaatttg ttaatgcacc acacaagtgc aaaataaaga ctgattcaca ttacataggc   4080
 aaaaaaaaaa                                                          4090



      <210> 2438
      <211> 810
      <212> DNA
      <213> Homo sapiens


      <400> 2438
 aatcgtagac ttcgtagacc ctaggcagtg cggtggaatt cccacaagat gtggacaagg     60
 aggcgatgat ggaagcaggc tgggacccct gcctgcaggc ccccttccac ctcaccccga    120
 ccctgtacag gacgctgcgt aatcaaggca accagggagc accggcggag agccgagagg    180
 tgctgcaaga cacggtcaac ctccttttca accatcccag gcagaggaat gcctcccggg    240
 agaacctgaa ccttcccgag ccccagcctg ccacaggcca gccacgttcc aggcctctga    300
 aggttgcagg cagccccaca gggaggctgg ctggagacca gggcagtgag gaagccccac    360
 agaggccacc agcctcctct gcaaccctga gacggcagcg acatctcaat ggcaaagtgt    420
 cccctgagaa agaatcaggg ccccgtcaga tcctgcggag cctggtccgg ctgtctgtgg    480
 ctgccttcgc cgagcggaac cccgtggagg agctcactgt ggattctcct cctgttcagc    540
 aaatctccca gctgctgtcc ttgctgcatc agggccaatt ccagcccaaa ccaaaccacc    600
 gaggaaataa gtacttggcc aagccaggag gcagcaggag tgcaatccca gacacagatg    660
 gcccaagtgc aagggctgga ggccagacag acccagaaca ggaggaaggg cctttggatc    720
 ctgaagagga cctctctgtg aagcaactgc tataagaaga gctgtcaagt ctgctggacc    780
 ccagcacagg tctggccctg gaccggctga                                     810



      <210> 2439
      <211> 2086
      <212> DNA
      <213> Homo sapiens


      <400> 2439
 tcacggccgg cgcctcctcc tggattcatt cactcgctct tttcattcac gaaggtagtg     60
 aggcctagtg gaaagccatg gagagcgctc tccccgccgc cggcttcctg tactgggtcg    120
 gcgcgggcac cgtggcctac ctagccctgc gtatttcgta ctcgctcttc acggccctcc    180
 gggtctgggg agtggggaat gaggcggggg tcggcccggg gctcggagaa tgggcagttg    240
 tcacaggtag tactgatgga attggaaaat catatgcaga agagttagca aagcatggaa    300
 tgaaggttgt ccttatcagc agatcaaagg ataaacttga ccaggtttcc agtgaaataa    360
 aagaaaaatt caaagtggag acaagaacca ttgctgttga ctttgcatca gaagatattt    420
 atgataaaat taaaacaggc ttggctggtc ttgaaatcgg catcttagtg aacaacgtgg    480
 gaatgtcgta tgagtatcct gaatactttt tggatgttcc tgacttggac aatgtgatca    540
 agaaaaatga taaatattaa tattctttct gtttgtaaga tgacacaatt ggtactgcct    600
 ggcatggtgg aaagatccaa aggggctatt ctgaacattt catctggcag tggcatgctc    660
 cctgtcccac tcttgaccat ctattctgca accaagactt ttgtagattt cttctctcag    720
 tgcctccatg aggagtatag gagcaagggc gtctttgtgc agagtgtcct gccatacttc    780
 gtagctacaa aactggctaa aatccggaag ccaactttgg ataagccctc tccggagacg    840
 tttgtgaagt ctgcaattaa aacagtcggc ctgcaatccc gaaccaatgg atacctgatc    900
 catgctctta tgggcttgat aatctcaaac ctgccttctt ggatttattt gaaaatagtc    960
 atgaatatga acaagtctac acgggctcac tatctgaaga aaaccaagaa gaactaagca   1020
 ttgataactg cattgtaact tggccagatg ctccagcata tgcacgttca ctgcaaagca   1080
 ccctactggt tttgaaaatc tgaccttgtc atttcaatag ttattaacat gactaaatat   1140
 tatcttaatt aagaggaaaa tagaagttgc ttttaggggt ttctgacata tattctggat   1200
 actatccgag gtaattttga agtttaatat aaatgctcat atcaaatgaa tatagaacta   1260
 atattgtcgg gaacacctaa tagaaaggaa tactattata gcaaatcaca gaatgataga   1320
 ctcaagcata aaacttggca gttttatctg cttcaaaatg ccattgatca ttattcctgt   1380
 attttctctg aaactgatta taaaaaccaa tgtccagcta ctcttttgtt tttgacactt   1440
 gaagaaatgg agatcgattt gatttgttta taagcagaca cactgcaatt tacaaagatc   1500
 tctttacggt tttataaaat tatcttccag tttgtacatt tatatggaat tgttctttat   1560
 caagggtagc taatgacatg aaaataattg tgaaatatgg aattatttct gacacatgaa   1620
 gcccactaaa ctatgctttc ttataatgca tatttcttct cagtttaaat gtatgtaaat   1680
 atcgaagcta tatggtatga tttataaaga taaatgggcc aaagtgtaca ttgagactgg   1740
 cagccatcta tggtaccact gaaaccctga cccagaaaag tggcttgctt ggacacccag   1800
 ctgcctttgt ttctgcatta aaccaatatt gatcacacat atgacacagg ctagtcctat   1860
 aaaagtaatg acttcataga aatggcatta taatttttaa gttgatactc tacaggtagc   1920
 tattgatata attagtttta ataaaacatg ctgcaaccat ggtatacaac aaaaatacat   1980
 ttctttggtg attgaaatta aggccgtatt tacaatgact taatataaga ctgacctttt   2040
 atcctgcttc ataaccttgt atggagaact caccaagaaa agaatt                  2086



      <210> 2440
      <211> 610
      <212> DNA
      <213> Homo sapiens


      <400> 2440
 cagatggtga gtgaccgcgg agctgggcag cacagatgca ggacgctgcc tccatcgcag     60
 aaagttctcc tggacgccac tgttccagat cctgatggtt caagtgctac ggatgcaata    120
 gctcagcgac tggcagcgca gcacgtacct gctgtcgtgg gaggtgagag ccaccagtgc    180
 ccgacagcgg ctgcaaggca gtggtggcgc tctgcagcca gccggcccac ccctccaaca    240
 tctgcaaggg ggtgggaggc tgcctcacca agctacctgc tactcatggg ggcgatgggc    300
 atcagggtgg cctgcctgga gccccgagag cacatagaag ctgccagatg agggcagtga    360
 ggccgagggc cggcagtagg gctgcagatg ccctgagccc taaggtcaag gtggatggaa    420
 ctgctgtgta agtctgatgc cgaggagacc aggtcgttgg gctttcaggt gagtggacgc    480
 tttctcccca ctcacaaccc ccaccatgca gtctctgctc ctccatggtc actgtggaat    540
 ggctcctgat ggcgctcaac cccttgccct gttttctccc ctgcggtcca ctgagccagc    600
 cctgcggccg                                                           610



      <210> 2441
      <211> 600
      <212> DNA
      <213> Homo sapiens


      <400> 2441
 cagatttctc aggtgagctc agatagcaat ccactgtgtt cctttatctc cagcagatat     60
 atatcaatat cttgaagcag ttttctactc aatttagaag aacttctggt taaatttaca    120
 attctttttt ctctcccatg cttgttgttt ctcattcaaa caagactggc atagctactt    180
 tatgagggta ggtctccctg aattttaagt tccaaagatc tctggacctg atcatattga    240
 ctttattccg tgggatcaac tcttcatggc cagttcttcc tctgtcactg agttcttagt    300
 gctgggcttc tctagccttg gggaattgca gcttgtcctc tttgcagtct ttctctgcct    360
 ctatttgatt atcttgagtg gaaacatcat catcatctca gtcattcatt tggatcacag    420
 cctccacaca cccatgtact tctttctagg tattctttct atctctgaaa tcttctacac    480
 aactgttatt ctgcccaaga tgcttatcaa cttattctct gtattcagga cactctcctt    540
 tgtgagttgt gccacccaaa tgttctacga aatcgtcggc ccgggaactc aggaacggtc    600



      <210> 2442
      <211> 5421
      <212> DNA
      <213> Homo sapiens


      <400> 2442
 tcatgatttg gctgtttgtc tgttattggt gtataaaaat gcttgtgatt tttgcacatt     60
 gattttgtat cctgagactt tgctgaagtt gcctatcagc ttaaggagat tttgggctga    120
 gacaatgggg ttttctagat atacaatcat gtcaactgca aacagggaca atttgacttc    180
 ctcttttcct aattgaatac catttatttc cttctcctgc ctgattgccc tggccagaac    240
 ttccaacact atgttgaata ggagtggtga gagagggcat ccctgtcttg tgccagtttt    300
 caaagggaat gcttcctgtt tttgcccatt cagtatgata ttggatgtgg gtttgtcata    360
 gatagctctt attatttgga gatatgtgcc atcaatacct aatttattga gaatttttag    420
 catgaagcgt tgttgaattt tgtcaaagga cttttctgca tctattgaga caatcatatg    480
 atttttgtca ttgtttctgt ttatatgctg gattatgttt attgatttgc gtattttgaa    540
 ccagtcttgc atcccaggga tgaagcccac ctgatcatag tggacaaact ttttgatgtg    600
 ctgctgaatt aggtttgcca ttgttttatt gaggatttta gcatcgatgt tcatcaggga    660
 tattggccta aaattctctt tttttgttgt gtctctgcca ggcttttgta tcaggatgat    720
 gctggcctca taaaatgagt tagggaggat tccctctttt tctattgatt ggaatagttt    780
 cagaaggaat ggtactagct cctccttgta cctctggtag aattcggctg tgaatccatc    840
 tggtcctcga ctttttttgg ttggtaagct attaactatt gcttcaattt cagagcctgt    900
 tattggtcca ttcagagatt caacttcttc ctggtttagt cttgggaggg tgtatgtgtt    960
 gaggaattta tccatttctt ctagattttc tagtttattt gcatagaggt gtttatagta   1020
 ctctctgatg gtagtttgta tttctttggt ctttgatgat ggtgacatac agatggggtt   1080
 ttggtgtgga tgtcccttct gtttgttagt tttccttcta acagtcagga ccctcagctg   1140
 caggtctgtt ggagtttgct tttggtccac tccagaccct gtttgcctgg gtatcagcag   1200
 cagaggctgc agaacagtta atactggtga gcagcaaatg ttgctgcctg aacgttcctc   1260
 tggaagtttt ttctcagagg agtacctggc catgtgaggt gtcagtgtgc ccctactgtg   1320
 gggtgcctcc cagttaggat acttgggggt catggaccca cttgcggagg cagtctgtcc   1380
 attctcagat ctccagctgc attctgggag aacctctact gtcttcaaag ctgccttggg   1440
 ccagagtgga gcccactgcc ctgaaaggtg tgtctcagca cagtcataag ctgactgaag   1500
 agccttaaga gaacataagc agtagtttgg cagtactctc tgtggacctg tgatggtggt   1560
 agccatggag ttaggctctt ccacaatggt agaactagtt tccagtcccg ccaacagtgt   1620
 aaaagtgttc ctatttctcc acatcttctc cagcacctgt tgtttcctga ctttttcata   1680
 atcgccattg taactggtgt gagatggtat ctcactgtgg ttttgatttg catttctctg   1740
 atggccagtg aggatgagca ttttttcacg tgtctgttgg ctgcataaat gtcttctttc   1800
 gagaagtgtc tgttcatacc ctttggccac tttttgattg ggttgtttgg tttttttctt   1860
 gtaaatttgt ttgagttctt tgtagattct ggatattagc cctttgtcag ataagtagat   1920
 tgcaaaaatg ttctcccatt ctgtaggttg cctattcact ctgatggtag tttctctttt   1980
 gctgtgcaga agctctttag tttaattaga tcccatttgt caattttggc ttttgttgcc   2040
 attgcttttg gtgttttaga catgaagtcc ttgcccatgc ctatgtcctg aatggtattg   2100
 cctaggtttt cttctagggt ttttatggtt tttgatctaa catttaagtc tttaatccat   2160
 cttgaattaa tttttgtata aggtgtaagg aagggatcca gtttcagctt tctacatatg   2220
 gctagccagt tttcccagca ccatttatta aatagggaat cctttcccca tttcttgttt   2280
 ttctcaggtt tgtcaaagat cagacagttg tagatacatg gcattatttc tgagggctct   2340
 gttctgttcc attggtctat atctctgttt tggtaccagt accatgctgt tttcgttact   2400
 gtggccttgt agtatagttt gaagtcaggt agcatgatgc ctccagcttt gttcttttgg   2460
 cttatgattg acttggcaat gcgggctctt ttttggttcc atatgaattt taaagtagtg   2520
 tttttccaat tctgtgaaga aggttattgg tagcttggtg gagatggcat tgaatctaca   2580
 aattaccttg ggcagtatgg ccattttcac aatattgatt cttcctatcc atgagcatgg   2640
 aatattcttc catttgtttg tgtcctcttt tattttgttg agcagtggtt tgtagttctc   2700
 tttgaagagg tccttcacat cccttgtaag ttggatttgt aggtatttta ttatctttga   2760
 agcaattgtg aatgggggtt cactcatgat ttggctctct gtttgtctgt tattggtata   2820
 taggaatgct tgtgattttt gcacattgat tttgtatcct gagactttgc tgaagttgct   2880
 tatcagctta aggagatttt gggctgagac aatggggttt tctaaatata caatcatgtc   2940
 atctgcaaac agggtcaaaa cagaagtcaa aaaaaatttg acttcctctt ttcctaattg   3000
 aatgcccttt atttccttct cctgcctgat tgccctggcc agaacttcca acactatgtt   3060
 gaataggggt ggtgagagag ggcatccctg tcttgtgcca gtttccaaag ggaatgcttc   3120
 cagtttttgt ccattcagta tgatattggc tgtgggtttg tcatagatag ctcttattat   3180
 tttgagatac gtcccatcaa tacctaattt attgagagtt tttagcatga agcgctgttg   3240
 aattttgtca aaggcctttt ctgcatttat tgagataatc atgtggtttt tgtatttggt   3300
 tctgtttata tgttgatcat ggtggataag ctttttgatg agttgttgga ttcggtttgc   3360
 cagtatttta ttaaggattt ttgcatcaat gttcatcaag gatattggtc taaaattctc   3420
 tttttttgta gtgcctctgc caggctttgg tatcaggatg atgcagacct cataaaatga   3480
 gttagggagg attccctctt tttctattga ttggaatagt ttcagaagga atggtaccag   3540
 ctcctccttg tacctctggt agaatttggc tgttaatcca tctggtcctg gacttttttt   3600
 ggttggtaag ctattaatta ttgcctcaat ttcagagcct gttattggtc tattcagaga   3660
 ttcaacttct tcctggttta gtcttgggag ggtgtatgtg tcgaggaatt tatccatttc   3720
 ttctagattt tctagtttat ttgcgtagag gtgtttatag tgttctctga tggtagtttg   3780
 tatttctgtg ggatcagtgg tgatatcccg tttgtcattt tttattgcgt ctatttgatt   3840
 cttctctctt ttcttcttta ttagtcttgc tagccgtcta tcaattttgt tgaacttttc   3900
 aaaaaaccag ctcctggatt cattgatttt ttgaagggtt ttttgtgtct ctatttcctt   3960
 cagttctgct ctgatcttag ttatttcttg ccttctgcta acttttgaat gtgtttgctc   4020
 ttgcttctct agttctttta attgtgatgt tagggtgtca attttagatc cttcctgctt   4080
 tctcttgtgg gcatttagtg ctataaattt ccctctacac actcctttga atgtgtccca   4140
 caaattctgg tatgttgtgt ctttgttccc attggtttca aagaacatct ttatttctgc   4200
 cttcattttg ttatgtaccc agtagtcatt caggagcacg ttgttcagtt tccatgtagt   4260
 tgagcggttt tgagtgagtt ttttaatcct gagttctagt ttgattgcac tgtggtctga   4320
 gagacagttt gttataattt ccattctttt acatttgctg aggagtgctt tacttccaac   4380
 tatgtggtca attttggaat aggtgtggtg tggtgctgaa aagaatgtat attctgttga   4440
 tttggggtgg agagttctgt agatgtctat taggtctgct tgctgcagag ctgacttcaa   4500
 ttcctggata tccttgttaa ctttctgtct cattgatctg tctaatgttg atattggggt   4560
 gttaaagtct cccattatta ttatgtggga gtctaagtct ctttgtaggt cactaaggac   4620
 ttgttttatg aatcttggtg cttctgtatt gggtgcatat atatttagga tagttagttc   4680
 ttcctgttga attgatccct ttaccatgat gtaatggcct tctttgtctc ttttgatctt   4740
 tgttggttta aagtctttgg tctttgatga tggtgacata cagatgggtt tttggtgtgg   4800
 atgtcctttc tgtttgttag ttttccttct aacagtcagg accctcagct gcaggtttgt   4860
 tggagtttgc tggaggtcca ctccagaccc tgtttgcctg ggaatcagca gcggtggctg   4920
 cagaacagcg gatattggtg aaccgcagat gctgctgcct gatcgttcct ctggaagttt   4980
 tgtctcagag gagtatctgg ccgtgtgagg tgtcagtctg cccttattgc actgtattaa   5040
 aacgatgcat tcatgtggcc acctctcctt catggtaagc accgtatctc cttcacctcc   5100
 ttctccataa cacagcacag cctctgaaat gaagccagtc ttcagcaagt gctttgatga   5160
 acagtaaatt ttgaagcagc tcttgaagac tcccttgagg tccattttct tttgctgaag   5220
 cccaaagagg tggggaatat agggaaagtc cttctctagg ttcccatggg aacagacatt   5280
 gccctttttc tcctcctcca acctttgagt ccaacctccg agtccaacct ccatcctgat   5340
 gctaccacca tctggatctc tccattcaag tgaccagaga agctcaccct tcacttcatt   5400
 caggtgtctg ctcagattca t                                             5421



      <210> 2443
      <211> 950
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> misc_feature
      <222> (1)...(950)
      <223> n = a,t,c or g


      <400> 2443
 ggatccattc ttatcaacag aatgtaacct ccaaggacct tgttagtctt gttcactgcc     60
 aggcttctaa tactaaaaat agtgggcata aagaagctgc tctataaata tttgtggaaa    120
 aaaagaaaaa gagaaaggaa ggcttgctgt tatattaaaa agcaatgggg ctggtaagct    180
 ccaacccagt gtcatgccaa agacaaaaga tcttcaaaaa aagcaatggn nnnnnnnnnn    240
 nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnct aggcgaattc acttactgac    300
 cggcctgggc tgctctgaga catggaggaa gccagtgaag gtggaggaaa tgatcgtgtg    360
 cggaacctgc aaagtgaggt ggagggagtt aagaatatta tgacccagaa tgtggagcgg    420
 atcctggccc ggggggaaaa cttggaacat ctccgcaaca agacagagga tctggaagcc    480
 acatctgagc acttcaagac gacatcgcag aaggtggctc ggaaattctg gtggaagaac    540
 gtgaagatga ttgtccttat ctgcgtgatt gtttttatca tcatcctctt cattgtgctc    600
 tttgccactg gtgccttctc ttaagtaaca gggaacctct cccacctgcc cttcttttca    660
 gggacaaccc tccataaatg tgtgccaaga gggtctcctt tcctgtcttc ctctacagag    720
 aatgctgctc ggtcctccta cccctcttcc cgaggccctg ctgccatgtt gtatgcccca    780
 gaaggtacct tggtcccccg gaaggagaga aaaaagagag atggactgtg gctgcatttc    840
 ttgggtcctt agagtgggct ggagagacct agagggccca gcatgtggct gggaaactgt    900
 tggtggccag tgggtaataa agacctttca gtatccctac aaaaaaaaaa               950



      <210> 2444
      <211> 512
      <212> DNA
      <213> Homo sapiens


      <400> 2444
 tttcgtgtcc cggcgcaacc acccgcactc agattctccc caaacgccaa ggatgggggt     60
 catggctccc cgaaccctcc tcctgctgct cttgggggcc ctggccctga ccgagacctg    120
 ggccggtgag tgcggggtcg ggagggaaag ggcctctgcg gggagaagcg agtggcccgc    180
 ccggcccggg gagccgcgcc gggaggaggg tcgggcgggt ctcagcctct cctcgcctcc    240
 aggctcccac tccttgaggt atttcagcac cgcagtgtcc cagcccggcc gcggggagcc    300
 ccggttcatc gccgtgggct acgtggacga cacagagttc gtgcggttcg acagcgactc    360
 cgtgagtccg aggatggagc ggcgggcgcc gtgggtggag caggaggggc tggagtattg    420
 ggaccaggag acacggaacg ccaagggcca cgcgcagatt taccgagtga acctgcggac    480
 cctgctccgc tattacaacc agagcgaggc cg                                  512



      <210> 2445
      <211> 583
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> misc_feature
      <222> (1)...(583)
      <223> n = a,t,c or g


      <400> 2445
 actgttctga gatctttgcc tccctcaggc tcccgagaat catggctcat tccaagcagc     60
 ctagtcactt ccagagtctg atgcttctgc agtggccttt gagctacctt gccatctttt    120
 ggatcttgca gccattgttc gtctacctgc tgtttacatc cttgtggccg ctaccagtgc    180
 tttactttgc ctggttgttc ctggactgga agaccccaga gcgaggtggc aggcgttcgg    240
 cctgggtaag gaactggtgt gtctggaccc acatcaggga ctatttcccc attacgatcc    300
 tgaagacaaa ggacctatca cctgagcaca actacctcat gggggttcac ccccatggcc    360
 tcctgacctt tggcgccttc tgcaacttct gcactgaggc cacaggcttc tcgaagacct    420
 tcccaggcat cactcctcac ttggccacgc tgtcctggtt cttcaagatc ccctttgtta    480
 gggagtacct catggccaaa ggtgcttctg accatactta ctggagcttc tggtccatgt    540
 ttctgcttgg aaatgcaccc ttttnaaatc atccctcttc ccc                      583



      <210> 2446
      <211> 2987
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> misc_feature
      <222> (1)...(2987)
      <223> n = a,t,c or g


      <400> 2446
 tttcgtcggg gccccgcccc tcctcggact ctacccagta ctgaactagg ggcagctggg     60
 ctccagagtc cctcgggtct caggtcatgg cggtcgcggg gcccgcgccc ggagctggcg    120
 ccaggcccag gttagatctg caatttctcc agcggttcct gcagatactg aaggttttgt    180
 ttccttcttg gtcatcacaa aatgccttga tgttcctgac ccttttgtgc ctgaccctac    240
 tggagcaatt tgtgatctac caggttggct tgatccccag tcagtactat ggggtcctgg    300
 gaaacaaaga cttggaaggg tttaagactc tgacattcct ggctgtcatg ctcattgttc    360
 tgaactccac gctgaagagc tttgatcagt tcacctgcaa cctgctgtat gtgagctgga    420
 ggaaggacct cactgagcac cttcaccgcc tctacttccg gggccgtgcg tactacaccc    480
 tcaacgtgct gcgggatgac atcgataacc cggaccagcg catcagccag gacgtggagc    540
 gattctgccg gcagctcagc agcatggcca gcaagctcat catctccccg ttcaccctcg    600
 tctactacac ttaccagtgc ttccaaagca caggctggct cgggcctgtg agcatcttcg    660
 ggtatttcat cctggggacc gtggtgaaca aaactttgat gggccccatt gtgatgaagc    720
 tggtgcatca ggagaagctg gagggagatt ttaggttcaa gcacatgcag attcgggtga    780
 atgcggagcc tgctgctttc tacagagctg ggcatgtgga gcacatgagg acagaccgca    840
 ggctgcagag actccttcag acccagaggg agctgatgtc caaggagctc tggctgtaca    900
 tcggcatcaa cacctttgac tatctgggca gcatcctgag ttacgttgtc atcgcaatcc    960
 ccattttcag cggggtctat ggagacctga gtcccgcaga gcttagcacc ctggtcagca   1020
 agaatgcctt tgtgtgcatc tacctcatca gctgcttcac ccagctcatc gacctgtcca   1080
 cgacgctctc agatgtggct ggctacacgc acagaattgg gcagcttcgg gagacgcttc   1140
 tggacatgtc cctgaagtca caggactgcg agatcctggg cgagagcgag tggggcttgg   1200
 acacaccccc agggtggcca gcggcagagc cagcagacac agcatttctc cttgagcggg   1260
 tctccatctc tgccccctcc tctgacaaac ccctaatcaa ggatctgagc ctaaagatct   1320
 ccgagggaca gagcctgctc atcacaggca acacgggcac tggcaagacc tccttgctcc   1380
 gggttctggg tggcctctgg acgagtacac ggggctcagt gcagatgctg acggactttg   1440
 ggccccatgg ggtgctattc ctgccacaaa agccattctt cactgacggg acccttcggg   1500
 agcaggtgat atatcccctg aaggaggtct accccgactc aggttctgcc gatgatgaga   1560
 ggatcttgag gttcttggaa ttggcaggcc tgtccaactt ggtggcaagg acagagggtc   1620
 tggaccagca ggtggactgg aactggtatg atgttctgtc cccgggggag atgcaacggc   1680
 tctcctttgc ccgactcttc tacctgcagc cgaagtacgc agtgcttgat gaagccacca   1740
 gtgccctgac agaggaagtg gagagcgagc tctatcgcat cggccagcag ctggggatga   1800
 cgttcatcag tgtgggacat cggcagagcc ttgagaagtt tcattccttg gttctgaaac   1860
 tctgtggagg aggaagatgg gagctgatga gaatcaaagt ggaatgaagc tctggctttt   1920
 ggaaggagaa cccacactgt ggcgggtcgg cggccctcaa gagacaccag gaggactgac   1980
 agcctgatct ccatgtggtg gttcggccca catagatccc cgtgcaggag cccgccaatg   2040
 gtcctgtgca gggacccccc tagcaagtgg gtggctgagc cccaggccta ggtttctgtg   2100
 ggggacattg aatctcccca gtgttcagtc tccccaggac tctgctgcct cagccagagc   2160
 ctccatatgc ttgaagtgct gattacctac aaatgatttc agatcatgtt tgctaaagag   2220
 aaatctggaa gtgtgagatc tgtaagaaat gaaagaaatg gantttggga gtcaagagat   2280
 ctggaaatct tttaatcagt taaattgtgc cagccaatag gatttttaaa ctttaactgg   2340
 accatttaag ttttttaata agttttttac aaaggaaagt taaaacatta aaaaggaatt   2400
 acagctttct gtcttctcta tcatggaatg atttttttta ttgaatctcc agatttgtat   2460
 ttgacagctt ggtgggaagg gaagcacact ctgctgttct ggaatcttat gcccagggtt   2520
 tttcacttct ccccacatct ccctttccac ttgccagtgt tgtgtagtta gaacctgaac   2580
 cactaacttc taggggcctt tggtctgccc cctaccctaa cccccaaatg aaagtaaatc   2640
 ccctttcccc cctagcccaa aataaggttg ggttttccta aaaaaatagt cctatattag   2700
 ggaacaacaa cagcaaatta gacaaaaccc cagaaagcac aaagcatgag gtggagttac   2760
 tgtgcccaaa gtcctcactc agaccagtgc ccctaccagt tcagttgtct atgtattacc   2820
 ttccttacct tcataatgtt tgccaggctt ctgtacttct agtacttgag ttacttaata   2880
 tttttaaaaa caaacctttt aagtttaaat ggatttttaa gtgaaatttt acacttaaca   2940
 tagatggaaa gtaactaaaa ataaatacaa gaaaaacaaa aaaaaaa                 2987



      <210> 2447
      <211> 510
      <212> DNA
      <213> Homo sapiens


      <400> 2447
 tttcgtccga aaccaaaaca caacaggctg tggaagagct gcgagcggcg cggcggggcg     60
 ggcgaacttc ggcgcggcac agagcctcgg gaggctgatg caactttccc tttaagaaag    120
 ccacctgggc gcaccgcggt gcggacccag cacgcctggg ccgggggctg cagcatgctc    180
 ttgagatctg tggcctgaaa ggcgctggaa gcagagcctg tgagtgtggt ccccgtcacc    240
 agagccccaa cccaccgccg ccatggtagg aaaaggtgcc aaagggatgc tgaatggtgc    300
 tgtgcccagc gaggccacca agagggacca gaacctcaaa cggggcaact ggggcaacca    360
 gatcgagttt gtactgacga gcgtgggcta tgccgtgggc ctgggcaatg tcaggcgctt    420
 cccatacctc tgctatcgca acgggggagg cgccttcatg ttcccctact tcatcatgct    480
 catcttctgc gggatccccc tcttcttcag                                     510



      <210> 2448
      <211> 7061
      <212> DNA
      <213> Homo sapiens


      <400> 2448
 tttttttttt ttgtccgtaa ggcttttatt ataaagaaga ttccagagtc ccagctgccc     60
 ccctccagcc cccatgggct ctgagccagt cccaacactg gctgagttgg ctgcgagggg    120
 cccgcatggc ccatcggcca cagagggtcg tttctggcag gaacggagtg ggtggtagtc    180
 tcaggcgcca ggggcgctct gccaggtctg cccgctctct ggaacagtca tttccagtgt    240
 tgcatgggga gcctctcggg acccctcccc gggtcctttg cgcaagcggc agctattcac    300
 agttggtgca tgatacgttt tttaatatat aaaagcttta aaaaaaaaag tggtgctatc    360
 tttagaaaca ctttcagcaa gatcaagtag cccagctaca gcctcggtgc atcttaaccc    420
 ctctcctttt cctggagacg gggctcccag ctcctgtgcc ccccatccct cccctccacc    480
 ctccctgctc ctggagaagc ccacagagca ccccatggcg cgggcactgc ccactctacc    540
 aacagccgcc caagcaacaa aaatctgaca ctacttgaaa ctgtctgtgg ccaggatcct    600
 ctacgggtga gggggaagtg gagataacat tttggtagtt gaagcagaaa ccaatcaaag    660
 gtcagttcaa ggagggctcc ctgcaccagt gtggatgagg tagagtttct gggctgcagc    720
 ctccgggctg gcggcctcct ctcccccagt ttgtgcttgg ccgcctggat gcacggggct    780
 cttggcagca ggaccaactg gacgttgtgg agcaagtggg tgggcacagt gcaggccgtg    840
 ctgggcagat gggggagcct gaccagctct ctggcctcca tcccagagac tgatctgggg    900
 acaggtggga ggggatggag gtgcccaggg gtcaaggcgg gggcgcccct gtctcagaga    960
 gcagcccctc ctcctgcccc cgccccagcc gtctctgctc agtatttccc agtctgagtc   1020
 acaggcacgg ggtagaagat caagttgagg cccagtgggc gtccatttct cccagcagca   1080
 gcctgaccaa ctctccatgt gtctcaggcc tcactgtagc actcgtagat gttgtcctcc   1140
 atcaaagcca ccacctgctc aaacttgtgc tgcagttgtg tcctccgggc cgtggggttg   1200
 gcctccagcg cggccatgat ctgcggccga tacctcttgg cgtacttata aatctctgcc   1260
 atggccacat tggtgttgaa ctcattctgg tatttcctcg actcctcggc cagatgggca   1320
 ttcatctctt gctcgctgag cggcgtcatg tcctggatct gcttgtagta gcgctgcacg   1380
 atcttccggt actcaggaat ctccttggcg tagaggagct tgttggttgg cgaatccttg   1440
 cccagctgca ggtcagagat ggagcaggcg tcgatgaagg cctgcgcgat gactgaaagg   1500
 caggcgtcga tgtggtctgt cttgtcgatg tcaaagacaa actgggggtt cttcaggatg   1560
 ttcacccaga accggagagg aaggctgttg gtcttccaga tgtgtagggt gtcggggtcg   1620
 gagattcccc tcttctcagc ctgctcctcc aggaagtcga aaaagtactt gacagccagt   1680
 gggggcttgt cttcacggat actcagaatg gccttgaaca ggtcatccag aaacttctgc   1740
 aacgtgccct tggtggagag caggcgggtc aggtagattt ccgggagcac cttcttgcga   1800
 tggctctgcc ggtgagactt cttgggctcc gccagctcgt ccgtaggcag caccaaatgg   1860
 aaatacttct ctgtgtccaa gtctttcact cggcccagtg tgttgtcctt cttgtctatg   1920
 agactcatgg ccagggaggc accttcaggg atcttgtaat gggccagcgt gttaagcttc   1980
 ttgcggccgt cttccaccac tgaggtgtcg tccaggtccc gaaggatgta gctctgtgtg   2040
 ctggaggcga accactcaag gtcgacgtcc tctgcacgcg gccactggga gtagggcaca   2100
 ttcttgcaga aggcctccag gatcttctcc ttgacctgtg tcagcgtgtc ggtgtccatg   2160
 gcccgcacgc tcagcgagtc catgccacag ccctggaagg acacgttcag gttccggggc   2220
 ttggcctcga tgttctcccg cagcagccac tcctcattga gtgtgtagcg ggccttgcct   2280
 gtgatggcgt cgatggagcc cttgttgatt tgctgcttga tggcacacag cagcaggaag   2340
 aatggctccc ccaccgtctc ccgcagacag ctgtacatgc agatggacat ccagttggtg   2400
 agcatcttct ccaccacaga ctctgtgcgc cgcagcatga gcttggggtt cttggcggcc   2460
 gaggcatcaa tgaggtccac cagcagctcc ttcatgatgc tggtgtagta ctccagcttg   2520
 ccgtgcagcg cgatggtcag cagcgaggcc aggctgcacc tgtcgcgcac cgcaaagtcc   2580
 ttctgctgct ccagcgcgtg gacaaagacg atgaggaagt gcttgttgtc gagtagtgag   2640
 gagaacaagc taattccctc ttccatgttg ggccggcagc tctcaggaat cttccactct   2700
 cccagcagtg ggtgggtttc ctgtgcctgg gagctgccct gggagttgag ggtctgggag   2760
 ggcagcacgt aacgctcttc ataaagggag gaacacttgg ggaagaaggt gcgggtcacg   2820
 aagtgcttat actccaggaa ggggatgccc tggctgcggt tcagctcctt ggtgagatct   2880
 gtcatgtctg tctgcagctc agcgaagcct ttgcggattt cctctcggat ctgagattcc   2940
 atctcctcca tctgcagcag cgtcttctgc cagtaacgct cagcacgtcg gctcttggta   3000
 cagaagacga acagggccac cacggagagc agcagcagga cgctgcagat gacgatggac   3060
 acgatgatgg ccgtctcgct gccccccagc tgcagtgtgg cgatggtctg gttgaagttc   3120
 cctacctgga ttgtgatggg cagctgcccc acggccgcgc ccagggactc gttgaccgag   3180
 cagtggatga ttctgtcaga gacaatctgg atgtcgcagc ttacttggcc tatcttgacc   3240
 cggtactcgt gactctggag ccccaggctg tcctgctcct tgtggataac gagggtgaga   3300
 ggctccccgg ggtggtgctt gatccacttc tccctcttgg ccgtagagaa ctgtgggttg   3360
 gggaggtagt ccaggcggaa cctgctgccc cgctgtgcct cctcggggtc cagtagctcc   3420
 tcagccacag ccacctcgtc tgcgtaggcc cgcccattga tgaagaagtc cactggcgct   3480
 gatgcgttgc tcagggcccc gggggacggg caggtgatga gggtggagtt gagaaccttg   3540
 cagagcgtgg gctcccggcc aatgtggtgg acggccatgg acacattctg caccatgtgg   3600
 aaacgctcac cagccactgt gatggtcctg ccgccactga cagggctgcg gcggggactg   3660
 atggccgtga tgaccgggtt ctgcatgtac cagaaggtga ggttgccgtg cacgcagccc   3720
 cgacgctcga agcgcacaca cacaggcacc ggagccggca gggccccctc aggcatggtg   3780
 caggcgatgc tggtatctgt gcgcatcagc tccgtgcagg ggtctgtgtc gttcaccagg   3840
 acctggagct cggagcctac atggaggtca ttcccatgga tggtgatcct ggtgcccccg   3900
 gccttggggc ccatggtagg ctccagggag tggaccaggg gcagcacgta ggagaagcgg   3960
 tcccgggact tgccctcctt agaggcgttc acggtcacca cacctgagag tggtcctggg   4020
 gctggccctg tgacacacac gatctcctcc gacaccgtgt atctgtcagg cagtggctca   4080
 caggccacac caccaatcca cacgccgtgg gccacgtcac tgagccgccg gcccaggttc   4140
 cttcctcgga tggtcagcag ggtcccaccg tccaacgggc cactcagggg ctcaatcgcg   4200
 cggatctcgg gggcggggca ggtgccagcc atgggctgca gaggcccccg caggcggcag   4260
 ccatcactcc acatacacag gtgacccagg tcttcgcggc ccaggcactg ggaacagtcg   4320
 gggctgccca tggcacagtt atagaccatg actgtcatgg gctcagggct gtccaggaat   4380
 cgggctggcc gcccctttag ttggaggctg agcgggaaca cctggctctt ccgggtcgtg   4440
 tgcagcacca cctggtcaca gcgtacaaca gactcattca cccacacagc ctcgaagatc   4500
 tcctccagcc caaaactaca ctccagggct gcaccctgga aaaaggcagt gttggccaga   4560
 ggcaccagga tgttctggga gccacccgta ggcacgggtg ccaggggtga gagcagggtc   4620
 cgggggcagt cctgagggct cgtggggttt ggtgaggcct cgcaccgaga ctggttggaa   4680
 acacaggagt gctgctggct gcaccagaaa cagggccact gtgccgacag gcagctggta   4740
 caggctgtgt gggggtacac ttgtgcagtg cggctgcagt cgtagatggt gaaattggcc   4800
 ttgacgatgt tccgcccatt gaccctcaca gacatctcaa cagtcacgtg gtcctggttg   4860
 ggggggaagg gcggaaactg gtccctcggc aggaggttgc agtaggcaat ctggtgacca   4920
 aaggcagggc ctgggacccg agccacagtg cggatgttgt tcccatagtc acaggccatc   4980
 tccatgccac tgaggctggg caggctgccc gagatctgca ggatcatgcc tgggtactcc   5040
 tggcgcacat cgatctcgga aggcaggacg gtcatggcag gacagcggct ggggccctcg   5100
 ctggcactgg tccagaaatg ctgctggctg gaattggtgc agtcctgctg caaggtgcac   5160
 cgcgtctcca gggcacacca gccgcagtag gcgtccgccg cacccacgca gtccccacag   5220
 gtggagtgca cgttgcaggc ggcgaccttc accctggcca tctggtggga cgtcatcagg   5280
 taaaggtaaa cggagtctgc tgggtcaaac tgcatgacat ggtgcacggg ctccccatag   5340
 gccacagtca ccacccgcct gctcaccacc tgcatgctct cgttcaggtt gatcttgaga   5400
 agcctcccgt tgaccgtgcc caggaagacc gctgtgtagt tgttgacgct ggccacggcc   5460
 acggaggtga ggcccggggc gcggaacacg ggcgtggcct tcaggggctg caggatggac   5520
 agcgggtgct gcaggtgagc agctccacag tccagctgct ctggctggag ctggatgttg   5580
 agcttgcgct cgcaggccgg tcccgtgccc tgcaccacgc tgtcgagcac cgccaccacg   5640
 tcgggcgccg gttccacgaa gcaggcggtg cgcgcagctc ggatggcggc tcgcacgtcg   5700
 gcgaagcgga aggcgcagag tgcggccgga gcagcgcggg ccgcggggga cccctggggc   5760
 cgctcgaaga cagcaaagag ccgctcccgg gctgggaaga ccgacaccag gcggctgtag   5820
 aggtcgccgc ggcccgcgcc gcccgcgcac tgcaagccca actggatgta ggactcggtg   5880
 agcttcttgg cgtcgccgcc ggcgccgtgg ggcaggcaga tgcgcgccag caggctccgc   5940
 gcctggctct ccttgtcgcc cgcgcgcgcc tcgctgttga gcgccaggta cgcgtaggac   6000
 tgtgcacccg gcggcgggtc ggacgggtgc aggaaggcgc tcacgaagcc cagcttgtgc   6060
 tgctccttgg cgccctgctt gatcttgagg atgttgtcgt cggaggggtt gaggtcgaag   6120
 gtgaagagct tggccaggtc gccgcgcgtg tccagggagc ggatggcgat ctcgggcgtg   6180
 ttctcgaagc ggtggtcctc caggctgcgg ttgcgcggga agaaggagct gccgtaaccg   6240
 gtgtacgtgg cgcccacgag caggcggctg ccccccgcgc ccgcggcggg aggcagaact   6300
 agccccacgg tggacgcgtt cgggtggttg gccgccacgt tcagcatgct ggggaacacc   6360
 gtgacgggct cggcgggcgg cgcggcgggc gggaagcgca cggccacggc cgagatgtta   6420
 ccccggcgcc gcagctggca gaagccctgg tagatggacc cgcacacgac taccaggccc   6480
 tggccggggt ccagctgcag gatcttgttg tagttgtccg tgaggcgccg cgggtgctcg   6540
 cacgaggcct gcggcagctg cggagcgtga cacagcgggc tgtcgggcac cgggcccacg   6600
 gccgcctcgg cctccaggct caggttggcg cccgacagct gatagaggcg gttgacggcc   6660
 gccaggtaca cggtccccgc cgcgccgtcc agggcgaagt tgttggtggg cgtgggcgag   6720
 gggaaccgac gctggatctc cagggcgccg gcccgcgccg cccccaggag cagcagcaac   6780
 agcagcggca ccgggcaccg cggcggcgtc tggaacggcg gggggctggc ggcggcggcc   6840
 cgggcgctaa ggggtgcgcc gcccgcggcg cgaggagcca tccgggcgtg cgcgggctgc   6900
 gcggcgcggc gagtgcatgg ggcgaggcgc ggccgggagc cgggagcccg gaggcggcgg   6960
 gaggcggggg gcgggcccgg gtccgcgagg cgcttcctgc ccgcgccagc cgcccccggc   7020
 cccggcgccc gggcccggct cagcctcgcc gcgcagcccg g                       7061



      <210> 2449
      <211> 2470
      <212> DNA
      <213> Homo sapiens


      <400> 2449
 agaatttgga gttgttttgg gcgcgacaga gcctggcggg gataccatta gcgtgtgtgt     60
 gtggactgca atgttgtctg tgcgcgtgtg tgtgagtgag tgagggagag agagagagaa    120
 taggtgtgtg tagaggcttc cggtgcctct gtctggctgc tgaggctgag atgggagcaa    180
 gtggctggcg aagctggtgg tggcttcaaa ccacactttc ttaaaacaat cgcaagagaa    240
 aattgttggg gggagggagg aggaggagaa ggcggttttt cttgcgtccc cccttctaac    300
 gctgcttttc tccttctctc tttccccctc atcccgtctt cccctcctcc cgtcctccct    360
 cgccccgcat gtactccccg tactgcctca cccaggatga gttccacccg ttcatcgagg    420
 cactgctgcc tcacgtccgc gctttctcct acacctggtt caacctgcag gcgcggaagc    480
 gcaagtactt caagaagcat gaaaagcgga tgtcgaagga cgaggagcgg gcggtgaagg    540
 acgagctgct gggcgagaag cccgagatca agcagaagtg ggcatcccgg ctgctggcca    600
 agctgcgcaa ggacatccgg cccgagttcc gcgaggactt tcgtgctgga ccatcacggg    660
 gcaagaagcc cccctggctg gcgttgctct ccaaccccga ccagaagggc aagatccggc    720
 ggatttgact tgcctgcgcc aggctgacaa agtgtggcgg ctggacctgg tcatggtgaa    780
 ttttgtttaa ggggggatcc cccctggaaa gtactgatgg ggagcggctc tacaagtcgc    840
 ctcagtgctc gaaccccggg cctgtgcgtc cagccacatc acaattggag tcacaatcaa    900
 agaactggat ctttatctgg cttacttttg tccaacaact ccggaatccc gacgatcaga    960
 tagttcaaac cagcatagag atgctggaca tcaaaccact gcccaacggg cacttaagtt   1020
 tccaggagct gttatgtgac ttccggggtc tggaatgtga ctggagctgg tgagagtatc   1080
 acagactcct gttgcaacag catcagggcc caacttctcc ctgggcggac ctgggagagt   1140
 cccagctact acaacattca accagggtga ccctgggggc gggcggtcca tcacctcccc   1200
 tcctttccac caggcaccac caaggcgccc caagttccat tcgatggaca gttgaggtgg   1260
 gagagccctg ttgatgacgt gttctatccg gggacagccc gttccccagc agctgccagc   1320
 agccagtcaa gcgggtggcc caacgatgtg gatgcaggcc cggcttctgc gaaagaagtc   1380
 aggaaagctg gacttctgca gtgccctctc ctctacaggg cagctccccg ctgcatggct   1440
 ttcacccacc acccgctgcc tgtgcttgct ggagtcagaa caagggagcc cccgggtcac   1500
 agcataagcc ttgcacttcc ccctcacggt cattcatcca gcagtcgagc cggtatttca   1560
 ggcacccgac catccgctac caccaccacc acgggcagga ctcactgaag gagtttgtgc   1620
 agtttgtgtg ctcggatggc tcggtccagg ccaccggaca gcattcgcaa cgacaggcgc   1680
 cttcttttgc caaccggttt gtcagcatcg gaccccggga cggcaacttt aatgaacatc   1740
 ccacagcagt ctcagtcctg gttcctctga taagttcgcc taaaagaagc aacaaaatga   1800
 gaagaagagg ttccctcgaa aggggggaga agaaattttg agaactggaa aactccccca   1860
 gccccagccc cagcccccac ccgaaaaagc aaaaaattaa cacgtcgtcc agcccactca   1920
 gccccttctc tccctcccaa gcccggggac ccccgcgggc ccccagaagc agcccaagtt   1980
 ctcagagagc cccttggaaa ggggtctcgg tggagctgtg caccagcagc caagcagaaa   2040
 gaaacacgcg acatggactc tgtcaagtag aggacagaaa gcaaagaaag gatgcagaac   2100
 tgccttcctc cccctgaccc cagcaccggc cttctgggga aggaacaaag tccccaaaca   2160
 aagcaaccag cacaattctg aaggggctgg gtctccccct cttctctgcc ctccaccccc   2220
 gtctctgcac tgagatacat aagaaacaag ggtagtttac tgtctgtttt gttttctggg   2280
 ttttcagtgt cctagcggaa tgcaagtagg cagccagccc gtctgttccc tctccgcccc   2340
 gccccgcccc gcccccggtc actgcgcbbt ctgttatacc atctttgcct gactctctcc   2400
 ggcttctcca ttgaatggct aatgtgtatg tgaaataaag aaataaagaa aaacaaacgc   2460
 gaaaaaaaaa                                                          2470



      <210> 2450
      <211> 3439
      <212> DNA
      <213> Homo sapiens


      <400> 2450
 ggcttatagg gctcgagcgg ccgcccgggc aggtatagaa ttcagcggcc gctgaattct     60
 agggttttca ggagcccgag cgagggcgcc gcttttgcgt ccgggaggag ccaaccgtgg    120
 cgcaggcggc gcggggaggc gtcccagagt ctcactctgc cgcccaggct ggactgcagt    180
 gacacaatct cggctgactg caaccactgc ctccagggtt caagcgattc tcttgcctca    240
 gcctcccaag tagctgggat tacagattga tgttcatgtt cctggcacta ctacaagatt    300
 catactcctg atgctactga caacgtggct tctccacagt caccaaacca gggatgctat    360
 actggacttc cctactctca tctgctccag ccccctgacc ttatagttgc ccagctttcc    420
 tggcaattga ctttgcccat caatacacag gatttagcat ccagggaaga tgtcggagcc    480
 tcagatgtta attttctaat tgagaatgtt ggcgctgtcc gaacctggag acaggaaaac    540
 aaaaagtcct ttctcctgat tcaccaaaaa ataaaatact gactaccatc actgtgatga    600
 gattcctata gtctcaggaa ctgaagtctt taaacaacca gggaccctct gcccctagaa    660
 taagaacata ctagaagtcc cttctgctag gacaacgagg atcatgggag accacctgga    720
 ccttctccta ggagtggtgc tcatggccgg tcctgtgttt ggaattcctt cctgctcctt    780
 tgatggccga atagcctttt atcgtttctg caacctcacc caggtccccc aggtcctcaa    840
 caccactgag aggctcctgc tgagcttcaa ctatatcagg acagtcactg cttcatcctt    900
 cccctttctg gaacagctgc agctgctgga gctcgggagc cagtataccc ccttgactat    960
 tgacaaggag gccttcagaa acctgcccaa ccttagaatc ttggacctgg gaagtagtaa   1020
 gatatacttc ttgcatccag atgcttttca gggactgttc catctgtttg aacttagact   1080
 gtatttctgt ggtctctctg atgctgtatt gaaagatggt tatttcagaa atttaaaggc   1140
 tttaactcgc ttggatctat ccaaaaatca gattcgtagc ctttaccttc atccttcatt   1200
 tgggaagttg aattccttaa agtccataga tttttcctcc aaccaaatat tccttgtatg   1260
 tgaacatgag ctcgagcccc tacaagggaa aacgctctcc ttttttagcc tcgcagctaa   1320
 tagcttgtat agcagagtct cagtggactg gggaaaatgt atgaacccat tcagaaacat   1380
 ggtgctggag atactagatg tttctggaaa tggctggaca gtggacatca caggaaactt   1440
 tagcaatgcc atcagcaaaa gccaggcctt ctctttgatt cttgcccacc acatcatggg   1500
 tgccgggttt ggcttccata acatcaaaga tcctgaccag aacacatttg ctggcctggc   1560
 cagaagttca gtgagacacc tggatctttc acatgggttt gtcttctccc tgaactcacg   1620
 agtctttgag acactcaagg atttgaaggt tctgaacctt gcctacaaca agataaataa   1680
 gattgcagat gaagcatttt acggacttga caacctccaa gttctcaatt tgtcatataa   1740
 ccttctgggg gaactttaca gttcgaattt ctatggacta cctaaggtag cctacattga   1800
 tttgcaaaag aatcacattg caataattca agaccaaaca ttcaaattcc tggaaaaatt   1860
 acagaccttg gatctccgag acaatgctct tacaaccatt cattttattc caagcatacc   1920
 cgatatcttc ttgagtggca ataaactagt gactttgcca aagatcaacc ttacagcgaa   1980
 cctcatccac ttatcagaaa acaggctaga aaatctagat attctctact ttctcctacg   2040
 ggtacctcat ctccagattc tcattttaaa tcaaaatcgc ttctcctcct gtagtggaga   2100
 tcaaacccct tcagagaatc ccagcttaga acagcttttc cttggagaaa atatgttgca   2160
 acttgcctgg gaaactgagc tctgttggga tgtttttgag ggactttctc atcttcaagt   2220
 tctgtatttg aatcataact atcttaattc ccttccacca ggagtattta gccatctgac   2280
 tgcattaagg ggactaagcc tcaactccaa caggctgaca gttctttctc acaatgattt   2340
 acctgctaat ttagagatcc tggacatatc caggaaccag ctcctagctc ctaatcctga   2400
 tgtatttgta tcacttagtg tcttggatat aactcataac aagttcattt gtgaatgtga   2460
 acttagcact tttatcaatt ggcttaatca caccaatgtc actatagctg ggcctcctgc   2520
 agacatatat tgtgtgtacc ctgactcgct ctctggggtt tccctcttct ctctttccac   2580
 ggaaggttgt gatgaagagg aagtcttaaa gtccctaaag ttctcccttt tcattgtatg   2640
 cactgtcact ctgactctgt tcctcatgac catcctcaca gtcacaaagt tccggggctt   2700
 ctgttttatc tgttataaga cagcccagag actggtgttc aaggaccatc cccagggcac   2760
 agaacctgat atgtacaaat atgatgccta tttgtgcttc agcagcaaag acttcacatg   2820
 ggtgcagaat gctttgctca aacacctgga cactcaatac agtgaccaaa acagattcaa   2880
 cctgtgcttt gaagaaagag actttgtccc aggagaaaac cggccatgcc aatatccagg   2940
 atgccatctg gaacagtaga aagatcgttt gtcttgtgag cagacacttc cttagagatg   3000
 gctggtgcct tgaagccttc agttatgccc agggcaggtg cttatctgac cttaacagtg   3060
 ctctcatcat ggtggtggtt gggtccttgt cccagtacca gttgatgaaa catcaatcca   3120
 tcagaggctt tgtacagaaa cagcagtatt tgaggtggcc tgaggatctc caggatgttg   3180
 gctggtttct tcataaactc tctcaacaga tactaaagaa agaaaaggaa aagaagaaag   3240
 acaataacat tccgttgcaa actgtagcaa ccatctccta atcaaaggag caatttccaa   3300
 cttatctcaa gccacaaata actcttcact ttgtatttgc accaagttat cattttgggg   3360
 tcctctctgg aggttttttt tttctttttg ctactatgaa aacaacataa atctctcaat   3420
 tttcgtatca aaaaaaaaa                                                3439



      <210> 2451
      <211> 1437
      <212> DNA
      <213> Homo sapiens


      <400> 2451
 ttggtcaaca aggcggttgt gacccactac gggtttcccc gtcaccaatt ttccctggaa     60
 ttggccagat ggcaagccac ccataatgat actatatgtg tccaagctaa acaaaatcat    120
 tcacttccct gattttgata agaaaattcc tgtaaagctg tttcctctgc ctctcctcta    180
 cgttggaaac cacataagtg gattatcaag cacaagtaaa ttaagcctac cgatgttcac    240
 cgtgctcagg aaattcacca ttccacttac cttacttctg gaaaccatca tacttgggaa    300
 gcagtattca ctcaacatca tcctcagtgt ctttgccatt attctcgggg ctttcatagc    360
 agctgggtct gaccttgctt ttaacttaga aggctatatt tttgtattcc tgaatgatat    420
 cttcacagca gcaaatggag tttataccaa acagaaaatg gacccaaagg agctagggaa    480
 atacggagta cttttctaca atgcctgctt catgattatc ccaactctta ttattagtgt    540
 ctccactgga gacctgcaac aggctactga attcaaccaa tggaagaatg ttgtgtttat    600
 cctacagttt cttctttcct gttttttggg gtttctgctg atgtactcca cggttctgtg    660
 cagctattac aattcagccc tgacgacagc agtggttgga gccatcaaga atgtatccgt    720
 tgcctacatt gggatattaa tcggtggaga ctacattttc tctttgttaa actttgtagg    780
 gttaaatatt tgcatggcag ggggcttgag atattccttt ttaacactga gcagccagtt    840
 aaaacctaaa cctgtgggtg aagaaaacat ctgtttggat ttgaagagct aaagagtctg    900
 cagcaggatt ggagactgac ttgtgactgc gggctggggg ggcattccca gtaggaatgt    960
 gaagccagag gtttcggatt cgtgacatcc accccctggg caagtgagag catctgcaaa   1020
 atgcaaagag aactacctca tatgcaggat gagccaatgg cagtctcaag aaatgtactc   1080
 gggcgacacc ttacctgtgg aaagcaaatc ttttcaaaat aagccactgg gactcggtag   1140
 gtggagcccc agctgctctt ctagggacct atggggcctt cgtggcatct ctgtgctgtg   1200
 tgctggggag gaggttgatg taatggtgac tcttttctga tcagcacctt ggccgtgatt   1260
 cccaaggtcc cagccaaagc aaagggccag ttgtttcagt ttaaacagac atgtctttag   1320
 tctaataaaa ttagttaact gccagtaaag ttatttgtta gctttgatga aagctatgtt   1380
 ggtatctttc cctaatcatc aaagtaaata aaaaatcatt tctaaaaaaa aaaaaaa      1437



      <210> 2452
      <211> 447
      <212> DNA
      <213> Homo sapiens


      <400> 2452
 gggtcgacca gatcgttctg aacttgtcag gatgcacatt ttagaagaaa catttgcaga     60
 gccatccctg caggctactc agatgaagtt gaaaagagct cgactagcag atgatctgaa    120
 tgaaaagatt gctcaaagac ctggtcctat ggagctggta gagaaaaaca tccttcctgt    180
 ggactccagt gttaaagaag caattatagg cgttgggaag gaggactatc cccacactca    240
 gggcgatttc tcatttgatg aagacagcag tgacgctttg tctccggacc agcctgcgag    300
 tcaggagtca caggggtcag ccgcgtcccc aagtgagcca aaagttagtg aatcgccatc    360
 tcctgtgact acaaacactc cagcgcagtt tgcttcagtg tccccaacag ttcctgaatt    420
 cttgaaaact cctccaactg cagatca                                        447



      <210> 2453
      <211> 800
      <212> DNA
      <213> Homo sapiens


      <400> 2453
 agcgaaacgg cgcagcaaat tatcgaccgt ctgcgcgtaa aactggcgaa agaaccgggg     60
 gcgaatctgt tcctgatggc ggtacaggat attcgcgttg gtgggcgtca gtcgaacgcc    120
 agctaccagt acacgttgtt atccgacgac ctggcggcac tgcgagaatg ggagccgaaa    180
 atccgcaaaa aactggcgac gttgccggaa ctggcggacg tgaactccga tcagcaggat    240
 aacggcgcgg agatgaatct ggtttacgac cgcgacacca tggcacggct gggaatcgac    300
 gtacaagccg ccaacagtct gttaaataac gccttcggtc agcggcaaat ctcgaccatt    360
 taccagccga tgaaccagta taaagtggtg atggaagtgg atccgcgcta tacccaggac    420
 atcagtgcgc tggaaaaaat gttcgttatc aataacgaag gcaaagcgat cccgctgtca    480
 tatttcgcta aatggcaacc ggcgaatgcc ccactatcgg tgaatcatca gggattatcg    540
 gcggccttga ccatttcgtt taacctgccg accggaaaat cgctctcgga cgccagtgcg    600
 gcgatcgatc gcgcaatgag ccagcttggt gtgccttcga cggtgcgcgg cagttttgcc    660
 ggcccggcgc aggtgttcca ggagaccatg aactcgcagg tgatcctgat tattgccgcc    720
 atcgccacgg tgtatatcgt gctgggaatc ccttacgaga ggtacgtaca tccgccgacg    780
 attctcttgt gaaggccgcc                                                800



      <210> 2454
      <211> 3678
      <212> DNA
      <213> Homo sapiens


      <400> 2454
 atgtgggcgt tattcatgat aagaaatgtg aaaaaacaaa gacctgttaa tctggaccta     60
 cagaccatcc ggttccccat cacggcgata gcgtccattc tccatcgcgt ttccggtgtg    120
 atcacctttg ttgcagtggg catcctgctg tggcttctgg agtacagact ctcttacctg    180
 aagggttcga gcaagcttcg cgattatggg cagctcttga ctctagagat cccggctgct    240
 ctcttgccta tccataccgg cattgttaac cagaatatca actgtaccga aacgctcaca    300
 gcaagcagcg ataatcttct gcggcgcgcc ttctgcggtg atacccacct gcatgaagtc    360
 cacctcaaca ccctgttttt caatcatttc ctttgtttcg ccgttatctt tgacgaaact    420
 aggaataaag atatttgcgc cacgtctggc cagcacgctc actttgtcga taagaaacgc    480
 aaacgcgaat tgctgtcgca catgattggg aaagggaact ggcagcaggt gctggtgttt    540
 acccgtacca aacacggcgc taaccatctg gctgaacagc tcaataaaga tggcatccgt    600
 agtgcggcga tccacggcaa taaatcgcaa ggtgcgcgta ctcgtgcgct ggctgatttt    660
 aaatcgggcg atattcgtgt actggtggca actgacatcg ctgcggcggc ctggatattg    720
 aagagctgcc gcacgtcgtc aactatgaac tgccaaacgt acctgaagat tatgtccacc    780
 gtatcgggcg taccggtcgt gcggctgcta ccggtgaagc gttgtcgctg gtccgtagtt    840
 tcttcgattg gtgcgatgat tgcgccgccg ctggtggtat gggcaatcgt aatgcacagc    900
 tggcagatgg catttatcat ctccggtgca ttgagcttta tctgggcgat ggcatggctg    960
 attttctata aacatccgcg cgaccagaag catctgaccg atgaagaacg cgactatact   1020
 attaatggtc aggaagccca gcaccaggtg agcacggcga agaaaatgtc cgttggtcag   1080
 atcctgcgta accgtcagtt ctggggtatc gcgctgccgg tgttcctggc agaaccggcc   1140
 tggggtactt ttgacgcgtg gatcccgctg ttcatgttta aagtttacgg ctttaacctg   1200
 atagagatcg cgatgttcgc ctggatgccg atgctgtttg ctgacctcgg ttgtatcctc   1260
 ggtggttacc tgccgccgct gttccagcgt tggtttgatg gtcgtaacgc tgggtacagt   1320
 gctgatgatt gccccggtat gatcggcctg ttcacaaccc gtatgtcgcc attatgccgc   1380
 ctttatcggt ggtttttccc acaggcactg tctggctccc tgaataccgt cttcccaatc   1440
 tggctgcggg tatttaccgt cgcgaagcat ctccagaggg cgggttattg tcatggcatc   1500
 tgtaccggcg aagggctgga aattgtcgga cagggtgact gtgtcattgt gcagtgggat   1560
 gcgaacagta acggtatctg ggatcgcgaa ccggtaaaag agtccgacca gattggattt   1620
 cgtctgaagg agcatgtgct ggaaacgcta cgcggtgcga catcctgtga aggtaagggc   1680
 tgggataaag tcactaatcc ggatgccatc attatcgaca cttttcaggt cgtacgtcag   1740
 gatgtcagcg gcttctcgcc ggtgttgacg gttaatatgc gtgctgccag aatgagccaa   1800
 caggatcgca gttttgcctc tcgcgtgagc atggaaagtc agtcattgcg ccgccaggcc   1860
 atcgttcagt cggcgctggc gtggggaaaa atgcactgct ggcagacgca gccagcagtt   1920
 cagtgctcgc agtacgctga aaccgatgcc cagtccgcgt tcttgcgcca gtatcgggct   1980
 ttatcacaac tacccgcatg cattgcaccg aagccgcatt tatatctccg tgactggatg   2040
 gtagtcgact atctgcccgg cgcggtaata acgtatttgc cggataccaa cgaactggca   2100
 ggcttgctgt attatctaca tcaacaacca cgttttggct ggcgaataac gcctgtttcc   2160
 gttactggaa ctgtactggc agcaaagcaa tccggcgcgg cggacatggg ttggctgcga   2220
 atgtttagac gtctgcgcaa atcgggcaag ccacggcctt tacccttaag tccattgcat   2280
 atggatgtcc acgccggaaa tttagtgcat agcgcgtcag ggctaaaact catcgactgg   2340
 gagtatgccg gagatgggga tatcgcgctg gaatctggcg gcggtggtgg tttgagtacc   2400
 gctggcgaca aaccggcgat cgacaattta tcaggctggc cgatgacagc tggcggcagc   2460
 tacaatagga gcaataagga gagcagtgtg ggtccagtaa tgttggatgt cgaaggttac   2520
 gaactggacg cggaagcgcg tgaaatactg gcgcatccgc tggtgggagg gctgagtctc   2580
 tttacgcgta accatcatga tcctgcccca ggtccgtggt taattcctga tgatgcaaag   2640
 ttacatcgca aactgttgcg ctggtacagc tcggtgcaaa caggtatggc ggaactcatt   2700
 cctgtcgctc aacagtggca aacggaagaa ccagaaagcg aagatgcccg ggcggtgatg   2760
 gctatcgccg gagccacaac ggctgcgatg acggtcgcgg gattcagcct gccgattgtt   2820
 ttgttaagcg ccctgggcac cggcatcctg gcgggattgt ggaacggcat actgatcgtc   2880
 acgtttaact cgccggatct ctcatggttc ggcagtggat cgctgttgtt cctgccaacg   2940
 ccggtcatta tcgcggtgct gacgcttatc ctgttctggc tgttgacccg caaaacggcg   3000
 ctggggatgt ttatcgaagc cgttggtatc aacattcggg cggcaaaaaa tgccggggta   3060
 aacacgcgaa tcatcgtcat gctcacttat gtgttgagcg ggctgtgtgc ggcgattgcg   3120
 ggcattatcg tggcggcgga tattcgcggt gccgatgcca acaacgctgg gttatggctg   3180
 gagctggacg ccattctcgc ggtggtgatt ggcggcggat cgctgatggg cgggcgcttt   3240
 aacctgctac tttcggtggt gggggcgctg attattcagg ggatgaacac cggaattttg   3300
 ctttcgggct ttccgccaga gatgaaccag gtggtgaaag cggtggtggt gctttgcgtg   3360
 ctgattgttc agtcgcaacg ctttatcagt ctgattaaag gagtacgtag ccgtgataaa   3420
 acgcctggtt tctggtgctt atatcgcttt gatccgcgtc gtgccgatga aggcaaactg   3480
 ccgctggcct tggattcacg cccgccgtca gaagcaccgg aagaaacgtt acttcacgag   3540
 caacgtttcc gtcggctgaa ttcgcagcag ccagaagtgg cagaacagtt atggaaagat   3600
 gctgcagctg atttgcaaaa acgctatgac ttcctggcac aaatggccgg aaaagcggaa   3660
 aaaagcaaca ccgattaa                                                 3678



      <210> 2455
      <211> 5301
      <212> DNA
      <213> Homo sapiens


      <400> 2455
 atggcctggc tgttgattat ttacattctg ccgttagtcg gaattattgc ctatcttgcc     60
 gttggcgagc tccatttagg caaacgccgc gctgaggccc atttgcgatt gtggccttcc    120
 accgcaaaat ggcttaacga ccttaaagcc tgtaagcata tcttcgccga agaaaatagc    180
 agtgtcgctg cgccattatt caagctttgc attgcgtcgt caggggattc gctggaggtc    240
 aaagggaatc agctacaact gatgaccgag tcagatgatg tgatgcaggc gttaatccgc    300
 gacatccagc tcgcgcgcca taatattgag atggtgtttt atatctggca gcccggcggc    360
 atgggcggac cagttcgaat accgcgtctg tcgtggtgct atgtacggca ccagatgaag    420
 cgacagccag gatttagccg ccaaagtgct ggcggaaaaa ctggcggcct gcgcgacctt    480
 gatccccggc gctacctctc tctattactg ggaagtctca tcatccatat caaaccccgg    540
 aacttctggt tttacctgtt acacacggag acacagatta cctctcatgg ctcaacgcat    600
 ctttacgctg atcctgctac tttgcagcac ttccgttttt gccggattat tcgacgcgcc    660
 gggacgttca caatttgtcc ccgcgatcaa gcctttgctt ttgattttca gcaaaaccaa    720
 catgacctta atctgacctg gcagatcaaa gacggttact acctctaccg taaacagatc    780
 cgcattacgc cggaacacgc gaaaattgcc gacgtgcagc tgccgcaacg tcctggcatg    840
 aagatgagtt ttacgcaaaa gcaagattta cccgcatcgg ctgacgcttc ccgtcaccat    900
 caaccaggca atgccggagc acgtttttta agtaaaacgc tttatggcgc gctggagcat    960
 aactttactg atgcctggag cggctttgtg cgcggctatg gctatgataa ccgtaccaat   1020
 tatgacgcgt attattctcc cggttcaccg ttgctcgata cccgtaaact ctatagccaa   1080
 agttgggacg ccgggctgcg ctataacggc gaactgatta aatcacaact cattaccagc   1140
 tatagccata gcaaagatta caactacgat ccccattatg gtcgttatga ttcgtcggcg   1200
 acgctcgatg agatgaagca atacaccgtc cagtgggcaa acaatgtcat cgttggtcac   1260
 ggtagtattg gtgcgggtgt cgactggcag aaacagacta cgacgccggg tacaggttat   1320
 gttgaggatg gatatgatca acgtaatacc ggcatctatc tgaccgggct gcaacaagtc   1380
 ggcgatttta cctttgaatg cgcagcacgc agtgacgata actcacagtt tggtcgtcat   1440
 ggaacctggc aaaccagcgc cggttgggaa ttcatcgaag gttatcgctt cattgcttcc   1500
 tacgggacat cttataaggc accaaatctg gggcaactgt atggcttcta cggaaatccg   1560
 aatctggacc cggagaaaag caaacagttg gaaggcgcgt ttgaatgctt aaccgctggg   1620
 gtgaactggc gtatttccgg atatcgtaac gatgtcagtg acttgatcga ttatgatgat   1680
 cacaccctgg aatatttaca actaagaact caccccggaa gggtttctac ggtcaaggtt   1740
 ttttactgtc ggaactttga aaaaaactgc gcggacctta cgaacatcat ccgaaaagga   1800
 ggaactatga aggctgcagt tgttacgaag gatcatcatg ttgacgttac gtataaaaca   1860
 ctgcgctcac tgaaacatgg cgaagccctg ctgaaaatgc agtgttgtgg tgtatgtcat   1920
 accgatcttc atgttaagaa tggcgatttt ggtgacaaaa ccggcgtaat tctgggccat   1980
 gaaggcatag gtgtggtggc agaagtgggt ccaggtgtca cctcattaaa accaggcgat   2040
 cgtgccagcg tggcgtggtt ctacgaagga tgcggtcatt gcgaatactg taacagtggt   2100
 aacgaaacgc tctgccgttc agttaaaaat gccggataca gcgttgatgg cgggatggcg   2160
 gaagagtgca tcgtggtcgc cgattacgcg gtaaaagtgc cagatggtct ggactcggcg   2220
 gcggccagca gcattacctg tgcgggagtc accacctaca aagccgttaa gctgtcaaaa   2280
 attcgtccag ggcagtggat tgctatctac ggtcttggcg gtctgggtaa cctcgccctg   2340
 caatacgcga agaatgtctt taacgccaaa gtgatcgcca ttgatgtcaa tgatgagcag   2400
 ttaaaactgg caaccgaaat gggcgcagat ttagcgatta actcacacac cgaagacgcc   2460
 gccaaaattg tgcaggagaa aactggtggc gctcacgctg cggtggtaac agcgttgatg   2520
 ctgtccgtgc aggcggtcgt gttgtggctg tcggtcaccg ccggagtcta tgagcctgga   2580
 tatccacgtc ttgtgctgga ctgtattgaa gtcgtcggtc taattctatg caatatgatg   2640
 tctataccca gacggaggtc tgtaatggca aaccatcgag gcggttccgg caattttgca   2700
 gaagaccgcg aaagagcatc agaagcaggt aaaaaaggtg gacagcacag cgtgggtaat   2760
 ttcaagaatg acccgcagcg cgcatctgaa gcagctcgtc aaaaagccat caccgccggt   2820
 tacccggtgg ttgatactga tgacaaatgt gtcaggcgtt acgccacaaa ccggaaacac   2880
 ctttccaaac atcacttcaa tcccgccctt ttcggtccta tgcttccgta tccgggattc   2940
 ttaaattccc attttcagct tacatgcctg cagtacaaaa atgattatcc ggacgactat   3000
 aacgaaaaag cggaacagga gctgacggcg aacgaaatct tcatgcagta cgtactgccg   3060
 aacaaactgc tgtggtatat cgccatcgcc aacgtgttcg tttatctgct gcgttacggc   3120
 atcctcgact ggtcaccgac ttatctgaaa gaggttaagc atttcgcgct agataaatcc   3180
 tcctgggcct acttccttta tgaatatgca ggtattccgg gcactctgct tcttccgtgg   3240
 caaccgtggg gcaaccggcg ttttctttat gacactggtg accatcgcga ctatcgttta   3300
 ctggatgaac ccggcagtaa cccaaccgtc gatatgattt gtatgattgt tatcggcttc   3360
 ctgatcaacg gtcctgtgat gctgatcggt ctgcatgcgc tggaactggc accgaaaaaa   3420
 gcggcaggta cggcagccgg ctttaccggg ctgtttggtt acctgggccg ttcggtggcg   3480
 ccagcccgat ttgttggcta cacgtggact tcttcggccg ggatggccgc tttatggtcc   3540
 atttacaacg tgccgctggt taccatcatc attatgggct ttttcttccc gcgcatcccg   3600
 gcgctggcgg caaaagtagc gatggggatt ggcataatca gctacatcac catcaactat   3660
 ctggtgaagt tcgacttcca tttcctctat gtgctggcct gtacgttctg catcaacgtg   3720
 gtcgtgatgc tggtgatcgg ttttatcaaa ccgcgcgcca cgccgttcac cttcaaagat   3780
 gcgtttgcgg tggacatgaa accgtggaaa aacgtcaaga tcgcgtcaat tggcatcctg   3840
 ttcgcgatga ttggcgtcta tgccgggctg gctgaattcg gcggctacgg tacgcgctgc   3900
 ggtaaaccgc ggaatacgca aaatattgat aatctggccg ccgaaggtat tcgcttaatt   3960
 ccgcctacac cgttcaccgg ttgtacgcct gaacgggccg gactattacc ggtatcaagc   4020
 ctaacagttc cgcccctgga caacaacttc gcgcagcaaa aacatcccca tatggggccc   4080
 tatttaagaa ggccgactga ccatcctgcg ctggaaaacg tcaatttcgc cctgaaaccc   4140
 ggtcagatgc tgggtatctg cgggccgact ggttccggca aaagtaccct gttgtcgctc   4200
 attcagcgtc atttcgacgt cagcgagggg gatattcgct ttcatgatat tcctctgacg   4260
 aagttacaac tcgatagctg gcgtagcgcc tggcggtatg ttagccagac gccattcctt   4320
 ttttctgaca ctgtggcgaa taacatcgcg ctgggttgcc cgaatgccac ccagcaagag   4380
 attgagcatg tcgcgcggtt agccagcgta catgacgata ttttgcgtct accgcaagtt   4440
 acggatacag aggtgggcga gcgcggtgtg atgccttccg gcgggcaaaa acagcgtatc   4500
 tccattgctc gtgcgttatt agtcaacgcg gaaatcctca tccttgatga tgcgctttcg   4560
 gcggtggacg gacgcactga gcaccagatc ctgcataacc tgcgtcagtg ggggcaagga   4620
 agaacggtaa tcatcagtgc ccatcgcctt tctgcactga cggaagccag tgaaattatt   4680
 gtgatgcagc acggacatat cgcccagctg gcaatcatga tgtgctggac aacaaagcgg   4740
 ctgttccgga tggctattga gcagcaaggc aacgttagtt tgcggtccgg tagacacaat   4800
 ggtgacaggt tccgcacttt cacgcagcgt tttcgccatc agctctaccg ccgtacagtt   4860
 ttgcggtgcg aatgtcggtt ccgatcaccc gattcgccac tttacggcaa agcccatttc   4920
 gtgggtcacc accatcatgg tcattccttc gttcgccagt tccaccatca cgtccagtac   4980
 tcgttgatca tctccggatc cagcgccgat gtcgtgcgcc ggaaacttat tggcgtgagc   5040
 agaaagcccg acacgctcca gcagtttcag ggctttttca cgagccggcg ctttatcgcg   5100
 tttaagcact ttcacctgcg ccagggtcag gttttcgata atcgacagat gagggaacag   5160
 ctcgaaatgc tggaatacca tcccgacgcg ggaacgcagc tttgccagat cggttttctt   5220
 gtcgttaacc acgataccat cgacggtgat ttcaccttgc tgcaccggtt cgaggccgtt   5280
 gacggtttta atcagcgttg a                                             5301



      <210> 2456
      <211> 999
      <212> DNA
      <213> Homo sapiens


      <400> 2456
 atggctggct tcctcgggct tgccctccta aggcgcccgc ttcgaacgct ttttccacgt     60
 acaccgagtc ccttggtaca ggcaccggtc ggccctacgt cctcgcgcat acagccggtt    120
 cggtgcgtta agccgcgctg tttcccgata gcgatttctg gttttgacag tggcttctct    180
 acctttgctc agggctttgt cgcgctgggg agtttccgtc tctcttacat caccttctac    240
 gcgttgattg cggtggcgtt cgtctgggtg ttgtggaaca aaacccgctt cggtaagaac    300
 atttttgcca ttggcggtaa cccggaagcg gcaaaagtat ctggtgtcaa cgtcggcctg    360
 aacctgctga tgatctacgc gttgtctggc gtgttctatg cctttggcgg gatgttagaa    420
 gccggacgta tcggctctgc caccaacaac ctcggcttta tgtatgagct ggatgctatc    480
 gcggcgtgcg tggtaggcgg tgtatcgttc agcggcggtg tggggacggt gattggcgtg    540
 gtgaccgggg taattatttt taccgtcatc aactatggcc tgacgtatat cggcgtaaac    600
 ccatactggc agtacatcat caaaggggcg attattatct tcgccgtagc gctggattca    660
 ctgaaatacg cgcgccggat aaggcgttca cgccgcatcc ggcagtggtg caccaatgct    720
 ggatacttac atcaacgccc ccataatctt caactccagc tcatccggca cttcgttata    780
 cgacagcaca tgcagccccg gcgcaaacaa ccttgcataa cgcgccagca aagggcgcag    840
 ctgcggtggc accagcagca ccgggtcttt ccccgccgct ttcatctgct ctttcacctg    900
 tggcatcgta ctctggaact ggttgagcat attcggatcg accggcacgc tgtcgagcat    960
 cactttcccg ccctgttgcg cctgattcac cacagttag                           999



      <210> 2457
      <211> 2001
      <212> DNA
      <213> Homo sapiens


      <400> 2457
 tcaatcaggc gaccaaagcg tgccagaccc atcagaatca aaaagatccc cgagcagcaa     60
 ggtcgcaacc agcagtcctg ccagtccaaa ctgttgcgac acgggataga gaattaccac    120
 aaatgccgca gtcggaccgg aaacgctaaa gcgtgaccca cccgtcagag caatgacaat    180
 ccccgcaaca gctgcggtat ataaaccgta ctggggtgcc acaccactac caatagccaa    240
 cgccatcgcc agcgggatag caataatccc gacggttatc ccggcaatca ggtcacgggt    300
 aaaccgtgcg gcagtatatt tttctgacag ggtcagagta cgcacgttcg gcagtgattt    360
 gatttcatcg ctcagcggaa tggtatcgca gacaacgact tcatcaatta cagagttacg    420
 caggttgttc gccgcgttgc cagagaagat cgggtgagtc gcgtacgcaa atacacgttt    480
 agcaccacgt tctttcagag cttcagcagc tttacacagc gtaccgccag tgtcgatcat    540
 atcatcgacc agtacgcagt cacgacctgc aacgtcaccg atgatatgca tcacctgtga    600
 aacgttcgca cgcggacgac gtttgtcgat gattgccata tcggtatcgt tcagcagctt    660
 agcgatagcg cgggcacgca caacgccgcc gatgtccgga atccttagag tatcaaaaag    720
 tggacagtta acacgaggca tataggtctg attccgatat tcaattggag tcagaccttt    780
 taatttcagg ctaattcttc tgctgttgta gtattcaata tattccgtaa cagcatcctt    840
 cagttcgctt atattactga actcatcaag ataaaaacac tccgacttta aggttccaaa    900
 gaaacactcc accacagcat tatccagaca attgcctttt ctggacatgc tttgtttaat    960
 accatgttct ttaaggatat tttgatatct tctcatacga tactgccatc cctggtcaga   1020
 gtgcagaaca ggatgctcgt gaggattaag ctttttgaat gcctgatcga gcatattctc   1080
 aaccatgttc atcactggtc tttccgaaag gctgtaagaa ataacttcgt tgttgaagag   1140
 atctattact ggagacaaat acagcttgcg cccattgact gcaaattcag taacatcggt   1200
 aacccacttc tcgtttggcc gcgtagcctt gaaatctctt tggagaacat taggggcggt   1260
 ttgccctacc tctcctctgt aagagcggta tcgcttgacc ttaatcgctg ctttaagtga   1320
 gagggttccc atcaggcgct gaacagcttt atggttaatc tgtttccctt ctcgatgaag   1380
 agacagcgtt accctacggt atccgtatcg gcctctattc tcgtgataaa tctcactaaa   1440
 tacgcttttt aacgtccgca tacttgtcag gcttgctgag agctttttcg tgggatgagc   1500
 taaggctttc agctttttta gatacataag ccgcgtttca agaaatcgaa cttgcctttc   1560
 aagatcctca atgcgtcggt cttttgacag ctccaatgct gatgccgctt tttctggatc   1620
 aactgatatt gcaatgtttc ttttggtgcc aatcttgagc gcgcgtaaac cagcttctcc   1680
 gcgctcttca tagaccttca gccacctggc tacagaacca ctaccagcaa gcataaagtg   1740
 agcagcagcc tgattaaggg acatgtgctg ctcgatcaca gctttcacga ccttaatacg   1800
 caactctgga tcagcactaa cgcctttagg tttgggaatt aaaccttttt ctccatgttt   1860
 ttcatagagg gcaacccatg tcctgacctg ggttcggggg acaccaaaac gtgccgagat   1920
 gatcctgtaa ccatcatcag ttgtgaagta gtgattcacg acttcaaggc gcttttcaaa   1980
 agggtatttt ggctttgaca t                                             2001



      <210> 2458
      <211> 1041
      <212> DNA
      <213> Homo sapiens


      <400> 2458
 atgttggtgg gggaaccggg taccgcaaaa tctcttcttt ctgaattact ggcaaccgct     60
 attagcggcg atgccgggtt aaccatccag ggcggggcat ctaccaccga agatcaaatc    120
 aagtatggct ggaactacgc cctgcttatc aatcatggtc cgtcaacgga agcgctggtc    180
 cctgccccgc tttatcaggg aatgcgcgac ggcaaaatcg tccgtttcga agagataacg    240
 cgtacaccgc tggaagtgca ggactgtctg ttagcttcag cactggcgct cggactggcg    300
 ttaatgggga atgcacaggc agtgacgacc attccgttct ggcattctat ggaaggggaa    360
 ctgggtaaag aggtggattc tctggcccaa cgttttaacg ccgaaaaccc ggattacaaa    420
 attgtaccga cctataaagg caactacgaa cagaatttaa gcgcggggat tgccgcattt    480
 cgtaccggca acgcgccgac gtattttgca ggtcatataa tgcaagcctg cggcgttgct    540
 ctttccgcta ctatctactt tattcgccgc aaagtggtta gtttaagcga tcagaaactc    600
 aatatcgcca tgacctttgt cggctcaatg agcggcgcac tgctggtgca atacgttcag    660
 gctgatgtct tacggcagat tttgcccatt ctggtaattt gtatcggcct ctatttcttg    720
 ctgatgccaa agctaggtga agaagaccgc cagcgccgga tgtacggttt acccttcgcg    780
 ttaatagccg gtggctgcgt cggtttttat gatggattct ttggcccggc tgccgggtcg    840
 ttttacgcgc tggccttcgt tacgctgtgc ggatttaacc tcgccaaagc cacggctcac    900
 gccaaattac tcaacgcaac gtcaaacatc ggcggtttac tgctgtttat tctcggcggc    960
 aaagtgattt gggcgacggg ctttgtcatg ctggtggggc agttcctcgg cgcgccgcat   1020
 ggggttccga cttgtgttta g                                             1041



      <210> 2459
      <211> 442
      <212> DNA
      <213> Homo sapiens


      <400> 2459
 ggaggcagga gggcaccccc tccgcaagaa ggggaccccg ctctgcctac tcccagtcct     60
 atgctccggt tctatttgat cgctggaggg attccactca ttatctgtgg catcacagct    120
 gcagtcaaca tccacaacta ccgggaccac agcccctact gctggctggt gtggcgtcca    180
 agccttggcg ccttctacat ccctgtggct ttgattctgc tcatcacctg gatctatttc    240
 ctgtgcgccg ggctacgctt acggggtcct ctggcacaga accccaaggc gggcaacagc    300
 agggcctccc tggaggcagg ggaggagctg aggggttcca ccaggctcag gggcagcggc    360
 cccctcctga gtgactcagg ttcccttctt gctactggga gcgcgcgagt ggggacgccc    420
 gggcccccgg aggatggtga ca                                             442



      <210> 2460
      <211> 1556
      <212> DNA
      <213> Homo sapiens


      <400> 2460
 tttttttttt ctatataaaa tgtttatttt tggaggactg tgtggtctgg tgtttgggag     60
 ggaactccac ccccaccagg ccaaccatgg agctagaaac agagacagca ggaagggcaa    120
 agctggccac tgcctgctcc accccttcac agcccagagc agaacagggt ctgctctact    180
 ctcaaggtga gtgacagaaa agccggtact gtttctgccc ctggcattcc cttagaaccc    240
 catgtgactt ctgtagtgct cagccccctg tgcccttccc tggggcctga tccacatgtt    300
 gtcaacaaaa cacactccct ctcacagtct ccaaacagca ctgcagagcc taagctcgca    360
 tcttgccagg atcaaagagg aatttttcac atttgctcac ttccaatctc catcttcctt    420
 cctctgtctc ccactctccc actctcagta gccgcatccc agccctgcca tactcccttc    480
 tcagggacag gagactcagt gggcagctgg cctcagctct cctaacagga aaaaaacctg    540
 tacagcatta gtgccagggc tcctgccctc ccaagcgctg agcccagaaa tttggacaaa    600
 tgagctgcct cttaactgca aaaaacaatt ttaaaaaagc aaaagatcaa acaaacagac    660
 caaaaagcat aaataaacag cagctgggcc agcaaggagg aaggcagggt gaccctcagt    720
 ggctccctgt gcccatctca gcctcttgcc ataaaactca gccatcagtg gccaggatga    780
 cagcagttcc gaagatgccc acactctctc caaggagctt catctggttc cagaactcaa    840
 cacgccgcgt gttgtgccag taagcaacat tgccatcaat gagcagcatg acagggggca    900
 gcagtacagc caggatctgg gcagcgaggg tcacgtagta gcctgacaga aaggccaggg    960
 ccaggatgcc atacagcacg aagaacagct ggatcatcag ctcccctcct gggagatggt   1020
 tcagatacgc cagccggtcc tccttgctgt gctgcagtga gtaggccaca cagatgaggt   1080
 agatacccag gaacacctgg ccggtggact gcagggagcg gctgcgaggt ttccggcggt   1140
 acagctcccc agcaccgctg gccaacacaa gaaagccgcc gatgatggca actgtgcgcg   1200
 agtacatacg gaccttcagc cagtccccgt agtggacgta gcccccgatg taggcggcgt   1260
 aggtgctaat ggccaattgg agtgcggccc ccagcgcgaa ccagcgccgc ttcacgccaa   1320
 aggacatgaa actagcgcac agcacggctg cccccatgtc gaaatacagg taaggcactg   1380
 ggatgtcggg cttccggcgt gcctcagccc tctcagcgta cagcatgagc tggctgaagc   1440
 agccccaaaa ggggcagcgt gtgagcagca ccgaacccaa ctgcatgatc agctgcaaca   1500
 tccaccgtct cgaacctatc ttcgacgcca tcttgggaaa gggcagtccg ctgcgg       1556



      <210> 2461
      <211> 999
      <212> DNA
      <213> Homo sapiens


      <400> 2461
 atgtctcgtg ttgctaaagc accggtcgtt gttcctgccg gcgttgacgt aaaaatcaac     60
 ggtcaggtta ttacgatcaa aggtaaaaac ggcgagctga ctcgtactct caacgatgct    120
 gttgaagtta aacatgcaga taataccctg accttcggtc cgcgtgatgg ttacgcagac    180
 ggttgggcac aggctggtac cgcgcgtgcc ctgctgaact caatggttat cggtgttacc    240
 gaaggcttca ctaagaagct gcagctggtt ggtgtaggtt accgtgcagc ggttaaaggc    300
 aatgtgatta acctgtctct ggccatactg cagacgagta ctcaagggtc tgaggtgtgt    360
 ggaccgtatc tgggaatcca acggattgct ccaacgtcgc agttcccaaa gcctagcgcg    420
 actacagaag atgcagcatc caaaatagca ctattaagtg ttgaactttc aagtgctttg    480
 gatagtattg atgttaacaa aactacaacg gatgtaagta tccttaatcg aagtattatc    540
 acacctggta ataatgttct ggttaataat actggaggtg acttaaacat aatttcgtcc    600
 gactctattc taaatggagc gactaaactc gtcagcggca caaccacgct gaagctttca    660
 gaaaatacaa tctggaatat gaaagatgac tccgttgtta cccatctgac taattcagac    720
 agtattatca atctttcgta tgatgatggt caaacattta cccaaggaaa aacattaacc    780
 gtaaaaggta attatgtcgg taataatggt cagcttaata tccgcaccgt attaggtgat    840
 gataaatcgg ctacggacag acttattgtt gagggtaata cttcgggttc aactaccgtc    900
 tatgtgaaaa atgctggagg aagcggcgcg gccacgctaa acgggatcga actcataact    960
 gtgaatggcg atgaatctcc agcagatgcc ttcagataa                           999



      <210> 2462
      <211> 1942
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> misc_feature
      <222> (1)...(1942)
      <223> n = a,t,c or g


      <400> 2462
 tttttttttt ttttagaata cctggtttat tcgggaaaac ttcataatga aaactacaat     60
 tagctttttc cacaacttac aaaataataa tctgatattt aaaatgaatt ggttttcatt    120
 atgtaagtcg aaatggtaaa aaatcataat gacctatccg atgcatcata tatatgctat    180
 tcagagaaac tcaaatcccc gaattctcct gtggcatgtt ttatatcaga catttaaaat    240
 ctgtttacca agaaagacca ggattttaac tatatgtagg tttctgctta cagttgcaaa    300
 ctatcagaag cctgtctata tgatagagcc cagataaacc tgagatttag aaaagcaagt    360
 catttattct cctgaggctg ttttagtggc acttttgtga caagaatgac cctcctaatg    420
 ctttactaca caacttaacc agatctatca gtcatgataa attagaccca gtccatcttt    480
 caatccagtc tactctggtt ctgaacatat aaacacaaaa cactacagat ttattaatat    540
 agcattttcc cacaccctaa ccctataaag aactttaaaa gagaaaattt catctaaata    600
 tttcacactt aaaggaaagc cttaccaact atggcaacag gtttggacca tgaaatagta    660
 ctttcctaga tgacatatcg agtcaacatg aagccttagc taaaatgaat gattcaggat    720
 attaatgaga aattctcaca aatgatatgc atttaggaaa tgattttgct ttccttaaat    780
 agttcgaagg cttgaaaata aacttttttt ttgcatttct tttagaatgt ttggtcatta    840
 acaactttta accttatctt cctcttctcc ttagccctta acagaccaag tccattctat    900
 ttggaaataa caagaacttg atcagattat taaatcttgg aaacctcatt tttaccttat    960
 aaagtgttaa gtttcacgtg catattctct tacaaatgta gtataaatgt tatggataga   1020
 tataaggaaa tattggcata gtataggtaa ttagtgaaaa gacacaactt cacaaaacat   1080
 aataaaagat aaacatgaaa ctataacact acttaaaaaa tattttctcc caaattattt   1140
 tagcattttt gactagttta ataatatgaa cactgccaaa aaatgggttc aaagtcgcct   1200
 ggagaaacag tttcttcttc tggagtccat ctcagcagca gcgattttct cccacattca   1260
 ttcccaagtt aggcagatgt gtagaagtac ctgggcttgg cattgcccag aaggtcatct   1320
 tcgtagttgg ggaggcagca gaagaagaag gcacagccga tcaggataat cgtggctgcc   1380
 cacccaaagc cgtaggccca gttatagatg taagtgacag cacggttggc atgaagggtg   1440
 aaggtctggg tgtacttcac ggggtaaatt accagggaga tgatctggaa cacagcagcc   1500
 aaggcaagga gacctccaat cactctcagg aagacaagca tctggggtcc acagagggcg   1560
 aagaaggaga ggatgaaaca gatcaccagg atgatgaagc cacagaagag catggcagcc   1620
 gctgctctac cccacgcgta ctccatgagg ctctgacagc cctcctcgta ggacccgctg   1680
 ccgccgccct cttgggagca tttccaccac agcgaggacg tctggccgtg gtcgctagac   1740
 tgcaaccagc cgcggccggc cagcgcgatg atgtcgaagg cgatggcgct gagtaggagc   1800
 aggggcagga tccagcggca gcgctcgcag gccaggccgc agcggatcat gttgacgggc   1860
 ggcgcggggc cgagcggagc ggagcggagc gggtcggagg agcgcgcggg acgggcgaca   1920
 gcagagagtg gccntgcgag cg                                            1942



      <210> 2463
      <211> 823
      <212> DNA
      <213> Homo sapiens


      <400> 2463
 gggggctaca ccaagagtgg ctatgactct gcatgtaaag actttgtccc tcatgacttg     60
 gaggtccaga ttcctggaag agtctttttg gtcactggag gaaacagcgg cattggcaaa    120
 gcaactgccc ttgaaatcgc caagcgaggt ggcacagttc acctggtttg tcgagatcaa    180
 gccccagcag aagatgccag gggtgagatc atccgggaga tgcggtaacc agaacatttt    240
 tctgcacatt gtggacttgt ctgatcccaa gaaaatctgg aaatttgttg aaaatttcaa    300
 gcaggaacat aaactccatg ttcttgatca ataatgcagg ttgcatggtc aataaaagag    360
 aagctcacaa gaagatggac tttgaaaaaa actttggttg ccaatactct ggggtgtgta    420
 catttctcac gacccggcct gatcccctgt gctggagaaa gaacacggac ccccgagtga    480
 taacccgtct cctcaggagg aatgttggtt cagaaactga acaaccaatg atctccagtc    540
 cgaaagaaca ccatttggat gggaactatg gtctatgcac aaaacaaggt cagtgagagg    600
 cagcaagtgg ttctgacggg agcggtgggg cccaagggca cccggccatc catttttctt    660
 ccatgcatcc tggctgggcc tgacacccca ggtgtgaggc aggcgatgcc ggggttccac    720
 gtccaggctt cggggtatcg cctgcgctcc gaggcccagg gcgcggacac catgctgtgg    780
 ctggccctct cctcagcacg cagccgcaca gcccagcggc cgc                      823



      <210> 2464
      <211> 1522
      <212> DNA
      <213> Homo sapiens


      <400> 2464
 ccacacgcgt ccgcccacgc ggccgataga tgtacatcgc gagcgggcga cctttctgtc     60
 cctcgttcgg ctgtccgcgc tcctcgccca gcccctactg cgcgcccgtc ctctacgcgg    120
 gcctgctgct actcggcctg gccgccagct ccgtgcggag caacctcacc tccttcggtg    180
 ccgaccaggt gatggatctc ggccgcgacg ccacccgccg cttcttcaac tggttttact    240
 ggagcatcaa cctgggtgct gtgctgtcgc tgctggtggt ggcgtttatt cagcagaaca    300
 tcagcttcct gctgggctac agcatccctg tgggctgtgt gggcctggca tttttcatct    360
 tcctctttgc cacccccgtc ttcatcacca agcccccgat gggcagccaa gtgtcctcta    420
 tgcttaagct cgctctccaa aactgctgcc cccagctgtg gcaacgacac tcggccagag    480
 accgtcaatg tgcccgcgtg ctggccgacg agaggtctcc ccagccaggg gcttccccgc    540
 aagaggacat cgccaacttc caggtgctgg tgaagatctt gcccgtcatg gtgaccctgg    600
 tgccctactg gatggtctac ttccagatgc agtccaccta tgtcctgcag ggtcttcacc    660
 tccacatccc aaacattttc ccagccaacc cggccaacat ctctgtggcc ctgagagccc    720
 agggcagcag ctacacgatc ccggaagcct ggctcctcct ggccaatgtt gtggtggtgc    780
 tgattctggt ccctctgaag gaccgcttga tcgacccttt actgctgcgg tgcaagctgc    840
 ttccctctgc tctgcagaag atggcgctgg ggatgttctt tggttttacc tccgtcattg    900
 tggcaggagt cctgggagat ggagcgctta cactacatcc accacaacga gaccgtgtcc    960
 cagcagattg ggggaggtcc tgtacaacgc ggcaccactg tccatctggt ggcagatccc   1020
 tcagtacctg ctcattggga tcagtgagat ctttgccagc atcccaggcc tggagtttgc   1080
 ctactcagag gccccgcgct ccatgcaggg cgccatcatg ggcatcttct tctgcctgtc   1140
 gggggtgggc tcactgttgg gctccagcct agtggcactg ctgtccttgc ccgggggctg   1200
 gctgcactgc cccaaggact ttgggaacat caacaattgc cggatggacc tctacttctt   1260
 cctgctggct ggcattcagg ccgtcacggc tctcctattt gtctggatcg ctggacgcta   1320
 tgagagggcg tcccagggcc cagcctccca cagccgtttc agcagggaca ggggctgaac   1380
 aggccctatt ccagccccct tgcttcactc taccggacag acggcagcag tcccagctct   1440
 ggtttccttc tcgggtttat tctgttagaa tgaaatggtt cccataaata aggggcatga   1500
 gcccttcctc acgaaaaaaa aa                                            1522



      <210> 2465
      <211> 1732
      <212> DNA
      <213> Homo sapiens


      <400> 2465
 aattcccggg tcgcgatttc gtggatgaga gcgcacgctt cggggtctcc gggaagtcgc     60
 ggcgccttcg gatgtggcgg atgcggccgt gagccggcgg gggaggtgct gctgctgcct    120
 ccactgtact cagacccagg tagcacagga ttgtccatcc tccagcagct cagtgcaacg    180
 gtgtgaactc agcctgtttc agagcctcca caccatgacc tccaagaagc tggtgaactc    240
 ggtggctggc tgtgctgatg acgctcttgc tggcctggtg gcctgcaacc ccaacctgca    300
 gctcctgcag ggccaccgcg tggccctccg ttctgacctg gacagcctca agggccgggt    360
 ggcactgctg tcgggtgggg gctctggcca tgagcctgcc catgctggtt tcatagggaa    420
 ggggatgctg actggggtca tcgcgggagc tgtgttcacc tccccggcag tgggcagcat    480
 cctggcagcc atcagggccg tggcccaggc cggcacagtg gggacgctcc ttatcgtgaa    540
 gaactacact ggggatcggc tcaacttcgg cctggcccgg gagcaggccc gggctgaagg    600
 catcccggtg gagatggtgg tgattgggga cgacagcgcc ttcactgtcc tgaagaaggc    660
 aggccggcgg gggctgtgcg gcaccgtgct tatacacaag gtggcaggtg ctctggctga    720
 ggctggtgtg gggctggagg agatcgcaaa gcaggtgaac gtggtcacca aggccatggg    780
 taccctgggg gtgagcttat cctcctgcag cgtccctggt tccaaaccca ccttcgagct    840
 ctcagccgac gaggtggagc tgggcctggg gatccacggg gaagctggtg tgcgccggat    900
 aaagatggca accgccgatg agattgtgaa actcatgctc gaccacatga caaacaccac    960
 caacgcgtcc catgtgcctg tgcagcccgg ctcctcagtt gtgatgatgg tcaacaacct   1020
 gggtggcctg tcattcctgg aactgggcat catagccgac gctaccgtcc gctccctgga   1080
 gggccgcggg gtgaagattg cccgtgccct ggtgggcacc ttcatgtcag cactggagat   1140
 gcctggcatt tctctcaccc tcctgctggt ggatgagcct ctcctgaaac tgatagatgc   1200
 tgaaaccact gcagcagcct ggcctaacgt ggctgcagtc tccattactg ggcggaagcg   1260
 gagccgggta gcccctgccg agccccagga ggcccctgat tccactgctg caggaggctc   1320
 agcctcgaag cggatggcgc tggtgctgga acgggtgtgc agcactctcc tgggcctgga   1380
 ggaacacctg aatgccctgg accgggctgc tggtgacggc gactgtggca ccacccacag   1440
 ccgtgcggcc agagcaatcc aggagtggct gaaggagggc ccaccccctg ccagccctgc   1500
 ccagctgctc tccaagttgt ctgttctgct cctggagaag atgggaggct catctggggc   1560
 gctctatggc ctgttcctga ctgcggctgc acagcccctg aaggccaaga ccagcctccc   1620
 agcctggtct gctgccatgg atgccggcct ggaagccatg cagaagtatg gcaaggctgc   1680
 tccaggggac aggactatgc tggattctct gtgggcagcg gggcaggagc tc           1732



      <210> 2466
      <211> 1761
      <212> DNA
      <213> Homo sapiens


      <400> 2466
 ctcctaagga actcattgtc tatagccctt agccttgtgg tttaggcaag aggccaggtc     60
 aggtgcccta gagtgaggca ggggcttcag ccaaagttgt gatcgcagct tctgaggcag    120
 ttcctcagtg gagtcagagt ccgctgccac ctgagctttc caccagatct tctttccttt    180
 ccttgtgctt tcctcaagct gcaggcttga tcccagccca caaatatgag agaattctgg    240
 aaagtgccct gagaaatggg ttctgggttt ttttttcatt tttatttttt taaatgtccc    300
 aggctgcctt cctgtcctcc catcctgcat cctgctttct gttccctgga taccgtagga    360
 tggttttatt tcagttcatg cacaaattag tctggacact gtggagtcat aacaagagtg    420
 ggatggaggt tccagggcca atcagtttct ttggagggaa gcttgagaag taggttagag    480
 caatgcccac aaaagccact gcttctcctt cccatcccca gcaatgagct aagagccaac    540
 ctcagccaga gagagggtct ttgatcacag agggtcagtc agtgggatgt gattagtggg    600
 gtttggggga tgggagtccc agggttaaac cagagggcaa agggatcctc tgagtcctgg    660
 cttaagggaa tggggtttca agttgagggt tggggactta gggcagggga gcagcaaggt    720
 gaggaaaaca gaaaggctgg catggcgagc atccttggca attcaacctg catgctgtta    780
 cactagcccc catttctgcc tttgctcaat ccaatggcca aagtcagtct atcctcagca    840
 gcaccttctg acacgatcca gtggtagtgt ccctcacctg tggccctcgg ggtgctgtcc    900
 actgtttttc acagacccag ccacccccca gctctggccc ctggttcttc acacataccc    960
 tgtcaggctg taggaattga actcactctt gactttggga ggttgaccag gccttggaga   1020
 gctccttgtg gcaagaggtt gggcttggta ggcatcgtag tagttggagc gatttctctg   1080
 gcatgagcag gaaaagcaga ggatgattcc agctatcagg gagaacaggg aagaaataat   1140
 gcccaagtaa agagcctctc caatctcaaa tttcatgctg tcaggcacca gtggtgagta   1200
 gaagtcccgt aggatcccat gaagattcca ggcaacagga atgaatccca ggaggcctcc   1260
 aaggatgaaa aagactccac ctgctaccgc cactctgtct ttggctcggg attcctggca   1320
 gaagactgtg catctcatgc ccaccacaga gataatgcag gccagggagg agattgcact   1380
 ggatgtcacc atcatggcct gggcagcctg gatgtcagcg ggcaggccca gaagggtgct   1440
 atagatgtca cactgggtga tgcctgtgct gtgtgtggca cattccatcc agaggccctt   1500
 ggagaagcca actgctgtca caatgctggc accgacataa gaacttgttt tccagctggg   1560
 gagcagcatg gcaaccagtg tgcccaaaag ccccagaagg cctaggatgt agcccacaag   1620
 ttggaggcca agagaggcca tggcagacct ctcagtagaa gcgtcttcag ggactgctcc   1680
 cttgtcttca ggctgaagct cttgctcctt gaacacctct aatccctcat ttcagagtct   1740
 ctctgccagg ctgacttctc t                                             1761



      <210> 2467
      <211> 3327
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> misc_feature
      <222> (1)...(3327)
      <223> n = a,t,c or g


      <400> 2467
 gtcctgccgc ttggccgcgg ggcgcctggc tcagtggctt ctgcgggctt cgaggagcgg     60
 gatgttgcgg gctgggtggc tccggggcgc ggcggcgctg gcgctgctgc tggcggcccg    120
 agtggtggcg gcgttcgagc ccatcaccgt gggcctagcc atcggggccg cgtcggccat    180
 caccggctac ctgtcctaca atgacatcta ctgccgcttc gccgagtgct gccgcgagga    240
 gcggccgctc aacgcttcgg ctctcaagct ggatttggag gagaagctgt ttggacagca    300
 tctagccacg gaagtgattg ttcaaggcgc tgactggctt caggaacaac aaaaatccca    360
 agaaaccact gaccctttcc ttacacggct gggctggcac aggcaagaat tttgtcagtc    420
 aaatgggggc tgaaaatctt cacccaaaag gtctgaagag taactttgtc cacctgtttg    480
 tatcgactct gcacttccct catgagcaga agataaaact gtaccaggac cagttacaga    540
 agtggatccg cggtaatgtg agtgcatgtg cgaactctgt tttcatattt gacgagatgg    600
 ataaattggc accccgggat cattgaaagc aatcaagccg tttctagact actacgagca    660
 cgttgaacga gtgtcttacc ggcaaagcca tcttcatctt tctcagcaat gcaggcgggg    720
 accttataac taagacggct cttgactttt ggcgggccgg aagaaagagg gaagacattc    780
 agctgaagga cctggaacct gtactgtctg tcggagtctt caataataaa cacagtggcc    840
 tgtggcacag tggactgatc gacaaaaacc tcattgatta ctttatcccc ttcctgcctt    900
 tggagtacag acatgtgaaa atgtgtgtga gggccgagat gagggcccgt ggttctgcca    960
 tagatgaaga cattgtcaca agagtggcag aggaaatgac gttttttccc cagagacgag   1020
 aaaatctact cagacaaggg ctgcaagact gtgcagtcgc ggctggattt ccactgagct   1080
 cctatccaga tggggtagga gacagctggg aggctctgca cgccagaggc cttgcctttc   1140
 agaagaaccc tgaagaccgc tttggggttt tgcctgtttg caccttagac ttttgggtat   1200
 agaatctttt ttttgagaag aggtctcact ccgtcatcca agctggagtg cagtggtgca   1260
 atcctcaact cactgcaacc tcccgctccc ggtttgagtg attcaccatt gcctcagcct   1320
 cccgagtagc tgggattaca ggcatgagcc actgtgccca gctgggatat agaatctaag   1380
 agttgattgt ggaaaacacg tgaatctatt gcgcgcattt gtcatttagc aagatggcag   1440
 cagtccagct gttctttgca gctggagatg aacttttaaa aatccccttc acacttaatg   1500
 tactgaccga gacagaagta cctgaaaaca gctgtgcatg gcaggcccgg caatagcttc   1560
 tgacccacag cacccgcgcc tcagaagcta cggtcacaac taaaggagtc cagggacttg   1620
 ctgcaggctg gggggcactg ggtggttctc accagcaggc tgcggggcac tgtgttctca   1680
 ttggccaaaa acatcctttt gctctgtctc gttctttaca cagagttcac tgacttgaag   1740
 tatactcagt taaaatcggg gctggaggtg cagacggtgt ctgaccggag gatgtggccg   1800
 tgcccgccga gcactcttga tctgagctga cctgtgtgtg tgtgtggggg ggggtggggc   1860
 cttcacctaa gacctctgca gcagacctgg acagacaggc ccctcccgcc tgtccatcgc   1920
 tctagctgct aatacagccc tggctgtgga atccttcacc gtctcagctg gtatcagccc   1980
 cagcctgcct tgtgccatat ctcagcttgg atctctgcta gagtcccccc aaccatatat   2040
 catagagttg aatcacaatg agaccgttgg ctttgaattt gagtcgttgg ttcccatggt   2100
 gagatgcttg ttaagacttt atacttgggt caatctctca ctttattttg tagaaccatt   2160
 tgaaatccta ggatgtgctt gttctggaag gatgacatgg gcccagactg aacaagtcag   2220
 cttgatgatc ttaaatgatg gaagtatagg acgttgctta ttttaaaaca agggaaggac   2280
 acaaaatgga atgactgctt agtcctttct cagatactct taaaacaatt ttttattgtt   2340
 aaatttgtgg taatacatgg tcacaaccgt ggatcaaaca aggtcagtct aaagtggcag   2400
 gtcctaggtg tgacctgata ccaccaccct ttgtggcagc accgggctgg actgccctga   2460
 tccctgggac gtgagactta gcttccagcc agtgtgaatc attgtatctg tctcataatc   2520
 acagcacagc tgcagacaca acaacgtgca gcatttttta cataaaaata tggtagaatt   2580
 aatttatgac atggaaatgc cttacgtggt atcacactta gtcttgaaaa aaacaccaag   2640
 gtgacgttta aaatttttag tacatatcct caaattggag ctaagttata cttcttttat   2700
 aaccttttgg gcatctggtc gagagaagac aagattttct ctatttacag tgatgcaata   2760
 aatatgtttg ccacctttgg actgccgtta ctgatttgta acttgaaaag gctatggttg   2820
 atcatgaccc cgcctccccc acctccctta taagatgtgg acgagagctt tattgaccta   2880
 ctgactataa aatagtaaat tctagatttt atcatgtgaa atgccacttg ctaacttttt   2940
 ctagtttatt tggttccaaa gttcagaatg aatttcagca gcacagctgt gagactcacc   3000
 atatccggga caggcgggtg ggcagtcagc gcgatacaga agcaatattt accttaaagg   3060
 ctcttcccca gacaaataga agttaaatta gctgatggat atttcatcaa agagatggac   3120
 tttctcccaa aattaacgtg ggaggaaatt gaggtactgg taaagtaaaa ctcacctctg   3180
 acagcctgaa cctgagctca ggtgaggaaa cctaaccatt gaaactggta aatannnnnn   3240
 nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn   3300
 nnnncccggc tcgagcggcc ggaattc                                       3327



      <210> 2468
      <211> 1538
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> misc_feature
      <222> (1)...(1538)
      <223> n = a,t,c or g


      <400> 2468
 acgacgacag tggcctgcac ttcttcctga cggcaccatc ttcctcgtgc tctgcatggg     60
 actctacctg ctgctgtcca ggctggagta tgccaggtac tacatgaggc ctgttcttgc    120
 ggcccatgtg ttttctggtg aagaggagct tccccaggac tccctcagtg ccccttcggt    180
 ggcctccaga ttcattgatt cccacacacc ccctctccgc cccatcctga agaagacggc    240
 cagcctgggc ttctgtgtca cctacgtctt cttcatcacc agcctcatct accccgccgt    300
 ctgcaccaac atcgagtccc tcaacaaggg ctcgggctca ctgtggacca ccaagttttt    360
 catccccctc actaccttcc tcctgtacaa ctttgctgac ctatgtggcc ggcagctcac    420
 cgcctggatc caggtgccag ggcccaatag caaggcgctc ccagggttcg tgctcctccg    480
 gacctgcctc atccccctct tcgtgctctg taactaccag ccccgcgtcc acctgaagac    540
 tgtggtcttc cagtccgatg tgtaccccgc actcctcagc tccctgctgg ggctcagcaa    600
 cggctacctc agcaccctgg ccctcctcta cgggcctaag attgtgccca gggagctggc    660
 tgaggccacg ggagtggtga tgtcctttta tgtgtgcttg ggcttaacac tgggctcagc    720
 ctgctctacc ctcctggtgc acctcatcta gaagggagga cacaaggaca ttggtgcttc    780
 agagcctttg aagatgagaa gagagtgcag gagggctggg ggccatggag gaaaggccta    840
 aagtttcact tggggacaga gagcagagca cactcgggcc tcatccctcc caagatgcca    900
 gtgagccacg tccatgccca ttccgtgcaa ggcagatatt ccagtcatat taacagaaca    960
 ctcctgagac agttgaagaa gaaatagcac aaatcagggg tactcccttc acagctgatg   1020
 ggtaacattc caccttcttt ctagcccttc aaagatgctg ccagtgttcg ccctagagtt   1080
 attacaaagc cagtgccaaa acccagccat gggctctttg caacctccca gctgcgctca   1140
 ttccagctga cagcgagatg caagcaaatg ctcagctctc cttaccctga aggggtctcc   1200
 ctggaatgga agtcccctgg catggtcagt cctcaggccc aagactcaag tgtgcacaga   1260
 cccctgtgtt ctgtgggtga acaactgccc actaaccaga ctggaaaacc cagaaagatg   1320
 ggccttccat gaatgcttca ttccagaggg accagagggc ctccctgtgc aagggatcaa   1380
 gcatgtctgg cctgggtttt caaaaaaaga gggatcctca tgacctggtg gtctatgggc   1440
 ctggggtcaa gatgaagggt cttttcagtg tttncctgtt ttacaacatg tcaaagccat   1500
 tggttcaagg gcgtaataca atacttgcgt attcaaaa                           1538



      <210> 2469
      <211> 1282
      <212> DNA
      <213> Homo sapiens


      <400> 2469
 aggggcagcg acgcggaaga tgactcaggg cccactttga acctcctggg tacttgagca     60
 agctcaaggg tgttcggacc tctagggaga cgttgcatca cgcagtttgg aaagaacttg    120
 ggaattctcc ctggggggct cgctgtattt actgggaact agtcttgcag gaaggcttat    180
 gtacagaagt acgtcgtgaa gaattatttc tactattacc tatcaatttt cagctgcttt    240
 gggccaagaa gtgttctaca tcacgtttct tccattcact cactggaata ttgaccctta    300
 tttatccaga agattgatca tcatatgggt tttggtgatg tatattggcc aagtggccaa    360
 ggatgtcttg aagtggcccc gtccctcctc ccctccagtt gtaaaactgg aaaagagact    420
 gatcgctgaa tatggaatgc catccaccca cgccatggcg gccactgcca ttgccttcac    480
 cctccttatc tctactatgg acagatacca gtatccattt gtgttgggac tggtgatggc    540
 cgtggtgttt tccaccttgg tgtgtctcag caggctctac actgggatgc atacggtcct    600
 ggatgtgctg ggtggcgtcc tgatcaccgc actcctcatc gtcctcacct accctgcctg    660
 gaccttcatc gactgcctgg actcggccag ccccctcttc cccgtgtgtg tcatagttgt    720
 gccattcttc ctgtgttaca attaccctgt ttctgattac tacagcccaa cccgggcgga    780
 caccaccacc attctggctg ccggggctgg agtgaccata ggattctgga tcaaccattt    840
 cttccagctt gtatccaagc ccgctgaatc tctccctgtt attcagaaca tcccaccgct    900
 caccacctac atgttagttt tgggtctgac caaatttgca gtgggaattg tgttgatcct    960
 cttggttcgt cagcttgtac aaaatctctc actgcaagta ttatactcat ggttcaaggt   1020
 ggtcaccagg aacaaggagg ccaggcggag actggagatt gaagtgcctt acaagtttgt   1080
 tacctacaca tctgttggca tcggcacaaa ggttgtagcg cagatgccaa cagatgtgta   1140
 ggtaaccttt gtgccgatgc ttcacaggtt tctgggatta ccctgagtct caaacagttg   1200
 gaaactagcc cactggacat gaaagccaag acataggaaa gttattggta ggcaaatctt   1260
 gacaacttat ttttctttaa ca                                            1282



      <210> 2470
      <211> 2086
      <212> DNA
      <213> Homo sapiens


      <400> 2470
 tcacggccgg cgcctcctcc tggattcatt cactcgctct tttcattcac gaaggtagtg     60
 aggcctagtg gaaagccatg gagagcgctc tccccgccgc cggcttcctg tactgggtcg    120
 gcgcgggcac cgtggcctac ctagccctgc gtatttcgta ctcgctcttc acggccctcc    180
 gggtctgggg agtggggaat gaggcggggg tcggcccggg gctcggagaa tgggcagttg    240
 tcacaggtag tactgatgga attggaaaat catatgcaga agagttagca aagcatggaa    300
 tgaaggttgt ccttatcagc agatcaaagg ataaacttga ccaggtttcc agtgaaataa    360
 aagaaaaatt caaagtggag acaagaacca ttgctgttga ctttgcatca gaagatattt    420
 atgataaaat taaaacaggc ttggctggtc ttgaaatcgg catcttagtg aacaacgtgg    480
 gaatgtcgta tgagtatcct gaatactttt tggatgttcc tgacttggac aatgtgatca    540
 agaaaaatga taaatattaa tattctttct gtttgtaaga tgacacaatt ggtactgcct    600
 ggcatggtgg aaagatccaa aggggctatt ctgaacattt catctggcag tggcatgctc    660
 cctgtcccac tcttgaccat ctattctgca accaagactt ttgtagattt cttctctcag    720
 tgcctccatg aggagtatag gagcaagggc gtctttgtgc agagtgtcct gccatacttc    780
 gtagctacaa aactggctaa aatccggaag ccaactttgg ataagccctc tccggagacg    840
 tttgtgaagt ctgcaattaa aacagtcggc ctgcaatccc gaaccaatgg atacctgatc    900
 catgctctta tgggcttgat aatctcaaac ctgccttctt ggatttattt gaaaatagtc    960
 atgaatatga acaagtctac acgggctcac tatctgaaga aaaccaagaa gaactaagca   1020
 ttgataactg cattgtaact tggccagatg ctccagcata tgcacgttca ctgcaaagca   1080
 ccctactggt tttgaaaatc tgaccttgtc atttcaatag ttattaacat gactaaatat   1140
 tatcttaatt aagaggaaaa tagaagttgc ttttaggggt ttctgacata tattctggat   1200
 actatccgag gtaattttga agtttaatat aaatgctcat atcaaatgaa tatagaacta   1260
 atattgtcgg gaacacctaa tagaaaggaa tactattata gcaaatcaca gaatgataga   1320
 ctcaagcata aaacttggca gttttatctg cttcaaaatg ccattgatca ttattcctgt   1380
 attttctctg aaactgatta taaaaaccaa tgtccagcta ctcttttgtt tttgacactt   1440
 gaagaaatgg agatcgattt gatttgttta taagcagaca cactgcaatt tacaaagatc   1500
 tctttacggt tttataaaat tatcttccag tttgtacatt tatatggaat tgttctttat   1560
 caagggtagc taatgacatg aaaataattg tgaaatatgg aattatttct gacacatgaa   1620
 gcccactaaa ctatgctttc ttataatgca tatttcttct cagtttaaat gtatgtaaat   1680
 atcgaagcta tatggtatga tttataaaga taaatgggcc aaagtgtaca ttgagactgg   1740
 cagccatcta tggtaccact gaaaccctga cccagaaaag tggcttgctt ggacacccag   1800
 ctgcctttgt ttctgcatta aaccaatatt gatcacacat atgacacagg ctagtcctat   1860
 aaaagtaatg acttcataga aatggcatta taatttttaa gttgatactc tacaggtagc   1920
 tattgatata attagtttta ataaaacatg ctgcaaccat ggtatacaac aaaaatacat   1980
 ttctttggtg attgaaatta aggccgtatt tacaatgact taatataaga ctgacctttt   2040
 atcctgcttc ataaccttgt atggagaact caccaagaaa agaatt                  2086



      <210> 2471
      <211> 6901
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> misc_feature
      <222> (1)...(6901)
      <223> n = a,t,c or g


      <400> 2471
 ctgcgggcgg cgggcggcgg gcgcaccatg ccctccttcg acgaggcgct gcagcgggtg     60
 ggcgagttcg ggcgcttcca gaggcgcgtg tttttgctgc tgtgcctgac gggcgtcacc    120
 ttcgccttcc tcttcgtcgg cgtggtcttc ctgggcacgc agcccgacca ctactggtgc    180
 cgcgggccaa gtgccgcggc gctggccgag cgctgcggct ggagcccgga ggaggagtgg    240
 aaccgcacgg cgcccgcctc ccgcggccca gagccccccg agcgccgcgg ccgctgccag    300
 cgctacctcc tggaggcggc caacgacagc gcctccgcca ctagcgctct cagctgcgcg    360
 gacccactcg ccgccttccc caaccgttcg gctccccttg tgccgtgccg cggcggctgg    420
 cgctacgccc aggcccactc caccatcgtc agcgagtttg accttgtctg tgtcaatgcg    480
 tggatgctgg acctcaccca agccatcctg aacctcggct tcctgactgg agcattcacc    540
 ttaggctatg cagcagacag gtatggcagg atcgtcattt acttgctatc ctgccttggt    600
 gttggcgtca ctggggttgt ggtggccttt gcaccaaact tccctgtgtt tgtgatcttc    660
 cgcttcctgc aaggtgtatt tggaaagggg acgtggatga cttgctacgt gattgtgaca    720
 gaaatagtag gttcgaaaca aaggaggatt gtgggaatcg tgattcaaat gttctttacc    780
 cttggaatca taattctccc tggaattgcc tacttcatcc ccaactggca aggaatccag    840
 ttagccatca cgctgcccag ctttctcttc ctcctttatt actgggtggt ccctgagtct    900
 ccccgttggc tgattactcg gaagaaagga gataaagcat tacagatcct gagacgcatt    960
 gctaagtgca atgggaaata cctctcatca aattactcag agatcactgt tacagatgag   1020
 gaagttagta atccatcctt tttagatctg gtgagaactc cccaaatgag gaaatgcaca   1080
 cttattctta tgtttgcttg gttcacaagc gcagtggtgt atcaaggact tgtcatgcgc   1140
 ctgggaatta tagggggcaa cctctatata gactttttca tctcgggcgt ggtggaactg   1200
 ccaggagctc tcttgatctt actaaccatt gagcgccttg gacgacgcct cccctttgcg   1260
 gcaagcaata tagtggcagg ggtggcatgc cttgtcactg cgttcttacc agaaggaata   1320
 gcatggttga ggaccacagt ggctacattg ggaagactag ggataaccat ggcctttgaa   1380
 attgtttatt tggtaaattc agaattgtac ccaacaacat tacgaaattt cggagtttcg   1440
 ctctgttcag gtctgtgtga ttttggggga atcatagccc catttctgct ctttcggcta   1500
 gcagccgtgt ggctagaact acctctgatc atctttggta tcctggcatc catctgtggt   1560
 ggccttgtga tgcttttgcc tgaaaccaag ggtattgcct tgccagagac agtggatgat   1620
 gtagaaaaac ttggcagtcc acattcctgt aaatgtggca ggaataagaa aaccccagtt   1680
 tcccgctctc acctttgagg cccccgacaa agacagaaag aaggagctat ccaggagctg   1740
 atcctccttg caaagctgtg ccttgcagag atgcacgtgt gcatttcagc tacatcatgc   1800
 cgcgctgttg taatactgta taaagacctc aatctatcca gagtattttt atataatgtt   1860
 ggatgagtta ggatttgtaa tgctgttgaa gtttctggga acacataata tgtagccagt   1920
 ttaacaaaga agctgtcagg tgcacagccc ttcctgggtt tttttcttgt gttccctgtg   1980
 gtctctgacc cattaggcta aagagagaca agagaagccc ccaacctgat tctcatgaca   2040
 gctccatcaa gaatgtggga tgtgccgacc aaggatttga gaaagttgta cagaaatgtg   2100
 ttcatcaaat ctggtcaagg gactaagctc ctagctgacc attcattctg aagattgcat   2160
 ggaggatgaa catctgggaa tcctgttaat gagaaggctg aatcacaggc acctgggcca   2220
 aagggtgtga gcattcatgt tctctgctca ccttggtttc cgcacacctt cgcaatgtga   2280
 acaggtcagg agtccctccc gtccacctcc tctgtaacag ctggggttcc aggcatggtt   2340
 taggccctgt tccagcaata agaaccaatc tgctgtacaa tctgaggact tggctgtgtt   2400
 atttacaaaa tgatgctgtg gttctgagat tatttgggac atttttggct ctcctttagt   2460
 ggacacctag agccacagat tcccttcttt actaaacaaa tcccatggat tctgatttct   2520
 gggtcttagg attttaaaag tgaagggata tttttcttat atttgtgagt tcagttccga   2580
 tggtgcccgt ggtcaaaagc gaaaaacatg gacaattcct attcattctt agcactttga   2640
 catgtcttgg ggaaaagctt tacattttaa tttaaaagaa agatcaatta tatccatgct   2700
 taacaggatc agcaggagct ttataaatga ctttacagag actaataagg gatttgatct   2760
 ttcttttttt gttatcgagg ctttggaaat gtggaactgg tgtgtcctgc tttatatgtt   2820
 atattccaat atcttttcag atgcagtcta tattttatgc tgagttttaa aaaaggaaat   2880
 acctttatgc caaacaggca aaattgggta ccaaagggaa acattaacca tgaggaagag   2940
 catttttcct aaggagaaca ggtgacaata tacacatgtg tgcctaatcc gtaaaatgag   3000
 catccttagt ctttaaaaca catcagaatt gaatacgaat aatctatttg tcaatgaaat   3060
 aaacacagct ctttgaggat ttgagactac attcaccctt tattcacagt cacttgcagt   3120
 tttgcttttc tctgcatttc tctgctgtaa gatgactgtt gcattgttaa attgtatttt   3180
 gaatggatat ttttgtttgg taacaatatt ttaaatggta aaacgtgtgc ctttgtcctt   3240
 tctcttcctt ctaaacatgt atctctccca caggtcattc tcctgtcacc gtgtgtactg   3300
 cagactgttt caaaaccggg cagggcaatt aggcaatggg gaaataaggt gggtcccacc   3360
 cttcaatatt tgcttgttgt tcatttacat gcttcttggc accaatccta gactcacgtg   3420
 tgcccccaga ataacattca gactctcagt tggtcttgtg ttaacacatc ccatggaacc   3480
 ggttccactc catccatata cagctctctg ctccggtgtc ccctgggcac aagtcaaggc   3540
 agtcggtgac agatttcatt cccaataaca gaatcggttc gcatgactcc ccatgcatgt   3600
 tgcagctttg aaaaccattc atctcagtgt caggaaataa agacagtaaa aaatgccatg   3660
 tcaagccctc gttagctgat gaggtaaatg cgtggacaac ttcttggctc tcccctctgt   3720
 gaccttgcag cctgctcagt cctttgtgca gctgttcctt atcaaaagca gctaaatccc   3780
 cccatctgcc catttaaaaa ttggtggggt gaacaaagag catgaaaatg ttgaagacca   3840
 aaaccaaaat ttacttcaaa tcaaagttaa agtaacaaga gtttattttt taacaaatgt   3900
 catagctatg tcaccattac tacagaatcc cgcagtcaga aaataacaca aaaaaatgcc   3960
 cgaggtttgg cgtacgtggt agctggggac agtgtcttcg tttgattact gccagttatt   4020
 tccaggcatg ctaaatcccc taccccacgg ttcccagcct ctagggtgag tcaggtgcgt   4080
 caactctgtc tccccgtccc aattaattaa tttctccatc aactcccctc aatcccaagt   4140
 aaacaaacct tggaaaacag ggaacatggg acacgggggg gttattgggg gccgttgcac   4200
 aagcccaaag acccccaaag aaagtgactc ccttggtaaa atggtatttt ggtccctttt   4260
 tngagggcaa acccagaggg gcccttccac tgttcaccct ggggggcaac ttgttcaggt   4320
 ggccttccgg gccaaaatgg cccaggcaca ggagtttcgg gtgggattgg gacttctttc   4380
 cattttcagg gaaacttcat agggcggatt tgcacacttt attctcaaat caacagggga   4440
 gctgggcttc ccttgaagaa ggcccagctc ccaaaagtac cttgggtttc tcccccagcc   4500
 cagtgatgaa acattcggtc ccggtcaacc gaaccacaaa aatttgggga atggccagac   4560
 aaagctggga ttaactttgt caagtgaatg aacggcagga ctgccttagc tttagcaagg   4620
 caaatatctt ttccgtgtgg gctcccaaga acagcctaag acactttcta tttcctgaac   4680
 atgcggttcc gagattcact tcttggtgtg caccccagga tgaccttgta ggatgaaggc   4740
 cttggggact tctccaagca gtgggcagca gtcaacgacc cactctgggg atatcaaggt   4800
 gcctccacag aagtgcaatc caaaaccttg ttctaaagac tgaacttgcc agggcccagg   4860
 aatgtggggt gggccacaca cccccctaca acccttccca ggacatttcc ttcggctcca   4920
 cttgaggctt ccccacaatc aaaatgaagg ggccgcacac tgagggacat cacagtagtc   4980
 gtaaagtttt cttggatttg tcgtgtagca ccagggacca catacactca ccatcagggt   5040
 tacggcagta atttttttcc agacccgccc cgtggagttt gtctctggag tgaaaatgct   5100
 gtgtcctaat ggggctcctg ggcagcccag tccctggcat ggcgtcccca gtaacaagtg   5160
 gtcgccctct tgcctcggta tcctttccca ttcccaaaca tacagtcttc ttcggaagga   5220
 gtcatataca tctggaagca ggacaacagg cggaggtgct aacaacactc gcttctgttc   5280
 ctgaagcatt ttttcaggtt gcagtactcc cacctgaacg ctgggggtct gtgggtaaaa   5340
 acaccagggg gcctttaatc ggccatctgg gattccctgc agtagttcca ttgtcaaggc   5400
 ccagcatttg gggtagtttt cctggggtcc ttcctggtgc ccggtgtggg tgtcatagga   5460
 tgacccaaag actgaacact tctttccctg tgggtgggtg ggtgggaggg atgttgcctc   5520
 ggtaagctct gtcccatcac ccatgggtag caagtccctg gaccacaggg gttagctcag   5580
 gtggtgctgt gggagccaat tgttccgtgg atactgggga ggagtcaaca ggaacggtaa   5640
 ccttaacaat aactccccac ccgcaacttg gcctgttggt tgtaatggca ccccaggggc   5700
 ccctttttcc cgtccaggat tgcggcaagt agttttccat cccaaatttt gccagggaaa   5760
 attttcctgg tgtccctgtt atgtgtgtga aggggtcctg tgcactccca gtgctgaaca   5820
 gttttccccg aacacggtta aacagccaca ttcccgcgaa aattttcacc tgttcccctt   5880
 caagacactg gtaaggtggg acccataaga tgggtggagg tgttgtgcaa gcgggggatg   5940
 tcaaaaaagt tccccagcgc ttgttggggt cgggtggtga aaacacccaa ggccgcaagc   6000
 cccctatcgg ggttacgaac agtaattcct tccttcaggt tcttgtttgg gaaaatttgg   6060
 gaaggaaagt atcccatgaa ccgtgtgggc tctgaagagt ccccaggcct ggcattccca   6120
 gtcccagaca tggtcttgga aattttgccg tcaatagttt tcctcccact gcaaatgcca   6180
 tacattccct ccttcaacac tcaaagaatg tcgcaagtag tcatatctct tttctggatc   6240
 aagtagtata gcacccaggg cccctgcgga tcgttgtctg gattcctgca gtagttctcc   6300
 ctccaagtcc ctcctgaggg gtgtgtagca aggtgaagaa tctaaggtct gcgggggaga   6360
 agtggaactc ccatttttga caaggtgatg ccatttttgt ttttggaaca tcgtcccctc   6420
 tgtaaatcct ttccaatccc caagtcttgg cactctgaag agaatacact ttctttttca   6480
 aaaataaaac taacatctcc tcatccctaa tgaattaatg gaggacttcc ctgttttcca   6540
 gccattatca cacattgttg ctctttactg tgatattggg aatgcccctg caggtgaaat   6600
 tcctttgtcc ctccttacat tttgcctgca cattccttct ctgcttccct gcccccagct   6660
 gccttcttag tgacactgaa cagtgaagcc ccctgggtat tcacatagtc atccagaggc   6720
 tctccttgac ctgatttcag aaataaaaga agtagaagaa ccacttcctt atgttccatt   6780
 ttgggactgg ccaggcagtg cccagaaaag tgggtcccaa tcccaggatg ttgttgactt   6840
 acatgagagt aaacgcatcc acagaccaga tagtcaaatt aagttaatga ttctctcaga   6900
 c                                                                   6901



      <210> 2472
      <211> 2246
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> misc_feature
      <222> (1)...(2246)
      <223> n = a,t,c or g


      <400> 2472
 gccggacttc cttggtctac gattacccgc tcaggcggcg gtggctgaga aggcagcggg     60
 gcggcggcgg cttttgtttt ggctgtggag gccgcagtcc gggtcctggc ttcggcctca    120
 gccccaccgt ggtgacgctt gctgaactgc tggtgctcct ggccgctctc ctggccacgg    180
 tctcgggcta tttcgttagc atcgacgccc atgctgaaga gtgcttcttt gagcgggtca    240
 cctcgggcac caagatgggc ctcatcttcg aggtggcgga gggcggcttc ctggacatct    300
 gacgtggaga ttacaggacc agataacatt ggaattttac ctacgagact ctacaatcta    360
 tctggcaaat acacatttgc tgctcacatg gatggaacat acaaattttg gttttagtaa    420
 cccggatgtc caccatgact ccaaaaataa gtgatgttca cgattggata ttggggaggc    480
 tccaaaaagg acaagatatc ggaaacagaa gctcaccaga acaagctaag aagaaatgat    540
 caatgagcta gcagtggcga ttgacagctg taaagcaccg aacacggaat acatggaagt    600
 ccgggagaga atacacagag ccattcaacg gacaacacaa aacagcagag tggtcctttg    660
 gtccttcttt gaagctcttg ttgcttgttg ccatgacatt tggggacaga tctactacct    720
 ggaaggagat ttttttgaag tccggaggag ttgttttaaa aagcctcttc ctggatgatc    780
 cccaactcag aattcacttg tttacccaaa caccttgggt cataaataat gtcattagtt    840
 tctccatttt tattttctga actggtacat tcacaactta tgtttctttg agattaatag    900
 atattggggg aaaaacgcct ttttagggaa aattatagtg aaaatttgac agttgattgg    960
 cataaatttc cttgtttgga atgctgcctc cattatatag ggtccttcca gggaactcaa   1020
 acactgtaag tgaaaatatg gggagtatag ttttttatta tttccctctt ttccttttgt   1080
 ttttcataat ataatggcag gttgttcagg aaaatccagc acaaagccct gatagtactt   1140
 ttactaaaaa tgactggcat tctttgggat tcccttcagt ctatggttca agtcactaaa   1200
 ggttccattt ttgttgagtc cctatgggga aacagcagta tgaatcttga cggtttctgc   1260
 ccgtcctaat ggcagagctc tctgacttgg gtgtatgctg ccaggctggg tactttcata   1320
 ctttgttttc ttgttttgct ttaaaaccta cgactcagca tacattttcc cacatacatt   1380
 tttacatttg taccttagga ctcagtcatc tccaacttaa aattgatgac accaagcagc   1440
 taataaccca tttctggggt ttctggccta aaccccctaa attgtctggt taaagccaat   1500
 tctctggggt gtcccagtgg agtgggtggc ttttttttct ttccacattg gcacattcac   1560
 ttctcccact cttggcatgt aagaaataag catttacata attggaaaaa tctggatttc   1620
 tgatgccaaa gggttaaagc ttcttgggat ttcatttcat tgatatacag ccactatttt   1680
 atttttgatc agtggccttt gggccactgt tcagggtact gaccatcagt gtcagcatta   1740
 gggttttggt ttttgtttct tttgggtctt tcttttttgg gcacatgtga atcttgtttt   1800
 gtgtcaaaat ggaaattact ttctcttgtt ctctgatgat ggggtttaaa attaaaagag   1860
 catccggttt tgggtatggg gggatgatcc cggggnttat gttgtgactg gatacatatt   1920
 agttacttgt gctttttttt tttttttttt ggatctttgg caagggcaaa actacaagta   1980
 acgagtttta tataattaat ttaaatttgt tacaggtttt catgttcagg ataaaccata   2040
 cttccacctt gggtgagaac acttgcaaca gtttattaat gaggtgactt tcaccttagg   2100
 acaactgttg catgccaagt tttttgtgtg tgtgaaacac ttcaaaactg atttaaaaga   2160
 tgtaaattta aaattggttg tatctaatat gccccaggtt cggtaaataa acaattcttt   2220
 ttaaaaacaa aaaaaaaaaa aaagcg                                        2246



      <210> 2473
      <211> 5976
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> misc_feature
      <222> (1)...(5976)
      <223> n = a,t,c or g


      <400> 2473
 cctccggtct acagctccca gcgtgagcga cgcagaagac gggtgatttc tgcatttcca     60
 tctgaggtac cgggttcatc tcactaggga gtgccagaca gtgggcgcag gccagtgggt    120
 gcgcgcaccg tgcggagccg aagcagggcg aggcattgcc tcacctggga agcgcaaggg    180
 gtcagggagt tccctttccg agtcaaagaa aggggtgacg gacgcacctg gaaaatcggg    240
 tcactcccac ccgaatattg cgcttttcag accggcttaa aaaacggcgc accacgagac    300
 tatatcccac acctggcctt cggagggtcc tacgcccacg gaatctcgct gattgctagc    360
 acagcggtct gagatcaaac tgcaaggccg cagcaaggct gggggagggg cgcccgccat    420
 tgcccaggct tgcttaggta aacaaagcag ccggggaagc tcgaactggg tgcagcccac    480
 cacagctcaa ggaggcctgc ctgcctctgt aggctccacc tctgggggca gggcacagac    540
 aaacaaaaag acagcagtaa cctctgcaga cttaaatgtc cctgtctgac agctttgaag    600
 agagcagtgg ttctcccagc acgcagctgg agatctgaga acgggcagac tgcctcctca    660
 agtgggtccc tgacccctga cccccgagca gcctaactgg gaggcacccc ccagcagggg    720
 cacactgaca cctcacacgg cagggtattc caacagacct gcagctgagg gtcctgtctg    780
 ttagaaggaa aactaacaaa cagaaaggac atccacaccg aaaacgcatc tgtacatcac    840
 catcatcaaa gaccaaaagt agataaaacc acaaagatgg ggaaaaaaca gaacagaaaa    900
 actggaaact ctaaaacgca gagcacctct cctcctccaa aggaacgcag ttcctcacca    960
 gcaacggacc aaagctggat ggagaatgat tttgacgagc tgagagaaga aggcttcaga   1020
 cgctcaaatt actctgagct acgggaggac attcaaacca aaggcaaaga agttgaaaac   1080
 tttgaaaaaa atttagaaga atgtataact agaataacca atacagagaa gtgcttaaag   1140
 gagctgatgg agctgaaaac caaggctcga gaactacgtg aagaatgcag aagcctcagg   1200
 agccaatgcg atcaactgga agaaagggta tcagcaatgg aagatgaaat gaatgaaatg   1260
 aagcaagaag ggaagtttag agaaaaaaga ataaaaagaa acgagcaaag cctccaagaa   1320
 atatgggact atgtgaaaag accaaatcta cgtctgattg gtgtacctga aagtgatgcg   1380
 gagaatggaa ccaagttgga aaacactctg caggatatta tccaggagac tttccccaat   1440
 ctagcaaggc aggccaacgt tcagattcag gaaatacaga gaacgccaca aagatactcc   1500
 tcgagaagag caactccaag acacataatt gtcagattca ccaaagttga aatgaaggaa   1560
 aaaatgttaa gggcagccag agagaaaggt cgagttaccc tcaaagggaa gcccatcaga   1620
 ctaacagcgg atctctcggc agaaacccta caagccagaa gagagtgggg gccaatattg   1680
 aacattctta aagaaaagaa ttttcaaccc agaatttcat atccagccaa actaagcttc   1740
 ataagtgaag gagaaataaa atactttaca gacaagcaaa tgctgaccga ttttgtcacc   1800
 agcaggcctg ccctaaaaga gctcctgaag gaagcgctaa acatggaaag gaacaaccgg   1860
 taccagccac tgcaaaatca tgccaaaatg taaagaccat cgagactagg aagaaactgc   1920
 atcaactaac gagcaaaatc accagctaac atcataatga caggatcaaa ttcacacata   1980
 acaatattaa ctttaaatgt aaatggacta aattctccaa ttaaaagaca cagactggca   2040
 agttggataa agagtcaaga cccatcagtg tgctgtattc aggaaaccca tctcatgtgc   2100
 agagacacac ataggctcaa aataaaagga tggaggaaga tctaccaagc aaatggaaaa   2160
 caaaaaaagg caggggttgc aatcctagtc tctgataaaa cagactttaa accaacaaag   2220
 atcaaaagag acaaagaagg ccattacatg atggtaaagg gatcaattca acaagaggag   2280
 ctaactatcc taaatatgta tgcacccaat acaggagcac ccagattcat aaagcaagtc   2340
 ctgagtgacc tacaaagaga cttagactcc cacacattaa taatgggaga ctttaacacc   2400
 ccactgtcaa cattagacag atcaacgaga cagaaagtca acaaggatac ccaggaattg   2460
 aactcagctc tgcaccaagc agacctaata gacatctaca gaactctcca ccccaaatca   2520
 acagaatata catttttttc agcaccacac cacagctatt ccaaaattga ccacatactt   2580
 ggaagtgaag ctctcctcag caaatgtaaa agaacagaaa ttataacaaa ctatctctca   2640
 gaccacagtg caatcaaact agaactcagg attaagaatc tcactcaaag ccgctcaact   2700
 acatggaaac tgaacaacct gctcctgaat gactactggg tacataacga aatgaaggca   2760
 gaaataaaga tgttctttga aaccaacgag aacaaagaca caacatacca gaatctctag   2820
 gacgcattca aagcagtgtg tagagggaaa tttatagcac taaatgccca caagagaaag   2880
 caggaaagat ccaaaattga caccctaaca tcacaattaa aagaactaga aaagcaagag   2940
 caaacacatt caaaagctag cagaaggcaa gaaataacta aaatcagagc agaactgaag   3000
 gaaatagaga cacaaaaaac ccttcaaaaa atcaatgaat ccaggagctg gttttttgaa   3060
 aggatcaaca aaattgatag accgctagca agactaataa agaaaaaaag agagaagaat   3120
 caaatagaca caataaaaaa tgataaaggg gatatcacca ccgatcccac agaaatacaa   3180
 actaccatca gagaatacta caaacacctc tacgcaaata aactagaaaa tctagaagaa   3240
 atggatacat tccttgacac atacactctc ccaagactaa accaggaaga agttgaatct   3300
 ctgaatagac caataacagg agctgaaatt gtggcaataa tcaatagttt atcaaccaaa   3360
 aagagtccag gaccagatgg attcacagcc gaattctacc agaggtacaa ggaggaactg   3420
 gtaccattct ttctgaaact attccaatca atagaaaaag agggaatcct ccctaactca   3480
 ttttatgagg ccagcatcat tctgatacca aagccgggca gagacacaac caaaaaagag   3540
 aattttagac caatatcctt gatgaacatt gatgcaaaaa tcctcaataa aatactggca   3600
 aaccaaatcc agcagcacat caaaaagctt atccaccatg atcaagtggg cttcatccct   3660
 gggatgcaag gctggttcaa tatacgcaaa tcaataaatg taatccagca tataaacaga   3720
 gccaaagaca aaaaccacat gattgtctca atagatgcag aaaaagcctt tgacaaaatt   3780
 caacaaccct tcatgctaaa aactatcaat aaaataggta ttgatgggat gtatttcaaa   3840
 ataataagag ctatctatga caaaaccaca gccaatatca tactgaatgg gcaaaaactg   3900
 gaagcattcc ctttgaaaac cggcacaaga cagggatgcc ctctctcacc gctcctattc   3960
 aacatagtgt tggaatttct ggccagggca atcaggcagg agaaggaaat aaagggtatt   4020
 caattaggaa aagaggaagt caaattgtcc ctgtttgcag atgacatgat tgttgatcta   4080
 gaaaacccca tcgtctcagc ccaaaatctc cttaagctga taagcaactt cagcaaantc   4140
 tcaggataca aaatcaatgt acaaaaatca caagcattcc tatacaccaa caacagacaa   4200
 acagagagcc aaatcatgag tgaactccca ttcacaattg cttcaaagag aataaaatac   4260
 ctaggaatcc aacttacaag ggatgtgaag gacctcttca aggagaacta caaaccactg   4320
 ctcaaggaaa taaaagagga tacaaaaaaa tggaagaaca ntccatgctc atgggtagga   4380
 agaatcaata tcgtgaaaat ggccatactg cccaaggtaa tttacagatt caatgccatc   4440
 cccatcaagc taccaatgac tttcttcaca gaattggaaa aaactacttt aaagttcata   4500
 tggaaccaaa aaagagcccg cattgccaag tcaatcctaa gccaaaagaa caaagctgga   4560
 ggcatcacac tacctgactt caaactatac tacaaggcta cagtaaccaa aacagcatgg   4620
 tactggtacc aaaacagaga tatagatcaa tggaacagaa cagagccctc agaaataacg   4680
 nngcttacct acaactatct gatctttgac aaacctgaga aaaacaagca atggggaaag   4740
 gattccctat ttaataaatg gtgctgggaa aactggctag ccatatgtag aaagctgaaa   4800
 gtggatccct tccttacacc ttatacaaaa atcaattcaa gatggattaa agacttaaac   4860
 gttagaccta aaaccataaa aaccctagaa gaaaacctag gcattaccat tcaggacata   4920
 ggcgtgggca aggacttcat gtccaaaaca ccaaaagcaa tggcaacaaa agccaaaatt   4980
 gacaaatggg atctaattaa actaaagagc ttctgcacag caaaagaaac taccatcaga   5040
 gtgaacaggc aacctacaac atgggagaca attttcacaa cctactcatc tgacaaaggg   5100
 ctaatatcca gaatctacaa tgaactcaaa caaatttaca agaaaaaaac aaacaacccc   5160
 atcaaaaagt gggcgaagga catgaacaga cacttctcaa aagaagacat ttatgcagcc   5220
 aaaaaacaca tgaaaaaatg ctcatcatca ctggccatca gagaaatgca aatcaaaacc   5280
 actatgagat atcatctcac accagttaga atggcaatca ttaaaaagtc aggaaacaac   5340
 aggtgctgga gaggatgtgg agaaatagga acacttttac actgttggtg ggactgtaaa   5400
 ctagttcaac cattgtggaa gtcagtgtgg cgattcctta gggatctaga actagaaata   5460
 ccatttgacc cagccatccc attactgggt atatacccaa atgactataa atcatgctgc   5520
 tataaagaca catgcacacg tatgtttatt gcggcattat tcacaatagc aaagacttgg   5580
 aaccaaccca aatgtccaac aatgatagac tggattaaga aaatgtggca catatacacc   5640
 atggaatact atgcagccat aaaaaatgat gagttcatgt cctttgtagg gacatggatg   5700
 aaattggaaa ccatcattct cagtaaacta tcgcaagaac aaaaaaccaa acaccgcata   5760
 ttctcactca taggtgggaa ttgaacaatg agatcacatg gacacaggaa ggggaatatc   5820
 acactctggg gactatggtg gggagggggg aggggggagg gatagcattg ggagatatac   5880
 ctaatgctag atgacgagtt agtggtgcag tgcaccagca tggcacatgt atacatatgt   5940
 aactaacctg cacaatgtgc acatgtaccc taaaac                             5976



      <210> 2474
      <211> 250
      <212> DNA
      <213> Homo sapiens


      <400> 2474
 ccataaatcc taaaccgcgc gtcgcggcaa tcagctccgc cgccaccagc gtagaccagc     60
 ccacccccag accaatacgt aatccggtga ggatttccgg cagcgcaccg ggcaaaatga    120
 caaaccacag cacctgcgca cggctggcac ccagcgactg ggcggcacga atgcgaacct    180
 gctgcacgct tttcaccccc gccagcgccg acatcgccac cggtgcaaaa atcgctaaat    240
 agatcagtaa                                                           250



      <210> 2475
      <211> 3978
      <212> DNA
      <213> Homo sapiens


      <400> 2475
 atgggctgct atgacgacat cgagcaggct gacgcgtttg tgctgtgggg cgcaaacatg     60
 gcggaaatgc acccgatcct ctggtcgcgc atcactaacc gtcgtctctc taaccagaac    120
 gtcaccgtgg cggtgctttc tacctaccag catcgtagct tcgagctggc ggataacggc    180
 atcatcttta cgccgcaatc tgacctggtg atcctgaact acatcgccaa ctatatcatt    240
 caaaacaatg cgataaatca ggacttcttc agcaagcacg ttaacctgcg caaaggggcg    300
 acggacatcg gctacggttt acgtccgacc catccgctgg aaaaagcagc gaagaatccg    360
 ggttctgacg cctccgaacc gatgagcttt gaagattaca aagccttcgt tgccgagtat    420
 acgctggaaa aaactgccga aatgaccggc gtgccgaaag accagttaga acaactggcg    480
 cagctgtatg ccgatccgaa caagaaagtc atctcctact ggacgatggg cttcaaccag    540
 catactcgtg gcgtgtgggc taacaacctg gtctacaacc tgcacctgct gaccggcaaa    600
 atttcccagc cgggttgcga tggcgcgtac gtgaaagtga agcctggtgc gcaaacagca    660
 attgttaatg gtcagcctct ggcactgcaa gtaccggtag tgatgaaaga caataaagcc    720
 tgggtttctg acacctttat taacgatgtt ttccagtccg ggctggatca aacctttcag    780
 gtagaaaagc gccctcaccc acttaatgcg ctaactgcgg acgaaattaa acaggccgtt    840
 gaaattgtta aagcttccgc ggacttcaaa cccaataccc gttttactga gatctccctg    900
 ctaccgccag ataaagaagc tgtctgggcg tttgcgctgg aaaacaaacc ggttgaccag    960
 ccgcgcaaag ccgacgtcat tatgctcgac ggcaaacata tcatcgaagc ggtggtggat   1020
 ctgcaaaaca acaaactgct ctcctggcaa cccattaaag acgcccacgg tatggtgttg   1080
 ctggatgatt tcgccagtgt gcagaacatt attaacaaca gtgaagaatt tgccgctgcc   1140
 gtgaagaaac gcggtattac tgatgcgaaa aaagtgatta ccacgccgct gaccgtaggt   1200
 tatttcgatg gtcaagatgg cctgaaacaa gatgcccggt tgctcaaagt catcagctat   1260
 cttgatgtcg gtgatggcaa ctactgggca catcccatcg aaaacctggt ggcggtcgtt   1320
 gatttagaac agaaaaaaat cgttactcgg tccgctacgt tgttgccttc atcatcagtt   1380
 acgccctgca taacggataa agactggcaa accaccagct ttggcagatt atcatcctgc   1440
 atatcaagaa atgctttcac ggtcagcgaa ctggcattga tggcagataa atccgccgcc   1500
 agcggcaata cggctgaagg tcggacttcc gccatggcag aaaacaggat cgtgttatcg   1560
 atcagatcga ttttggcatc aaagacaccg tcgaaattct gcatatgggg gcgtgagtat   1620
 caactgcaac cgaatgttga gtgggatgcg cactatctac acggcgatgg ctggctgggc   1680
 gagtggcaat gtgtctcgca cagcgatgat agtttgtgtc tggtgtatga acatcgcagc   1740
 ggtgtctatc actatcgggt aagtcaggcg tttcatttaa cggcggatac gctgacggtg   1800
 acgctctctg tcaccaatca aggggcagag acgctgccat ttggtaccgg ctggcatcct   1860
 tattttccgt tgtcgccgca aacgcggatt caggcacagg cgagcggtta ctggctggag   1920
 cgggagcagt ggctggcgga tcgtccgccg cttcctcaaa ccctgtttgc cgcctgtcag   1980
 catctgctgg cgatgttcgt tgcggtgatc acgccagcgc tattaatctg ccaggcgctg   2040
 ggtttaccgg cacaagacac gcaacacatt attagtatgt cgctgtttgc ctccggtgtg   2100
 gcatcgatta ttcaaattaa ggcctggggt ccggttggct ccgggctgtt gtctattcag   2160
 ggcaccagct tcaactttgt tgccccgctg attatgggcg gtaccgcgct gaaaaccggt   2220
 ggtgctgatg ttcctaccat gatggcggct ttgttcggca cgttgatgct ggcaagttgc   2280
 accgagatgg tgatctcccg cgttctgcat ctggcgcgcc gcattattac gccgctggtt   2340
 tctggcgttg tggtgatgat tatcggcctg tcgctaattc aggttgggtt aacgtccatt   2400
 ggcggcggtt acgcagccat gagcgataac accttcggcg tcagctcggt accatgtctt   2460
 cccggcgacg atggaactgt gcatctcgcc ttcggttttg cgctgattgt tggcatcccc   2520
 gtggggatga ttgccgggat tacgcgccat aagtggcagg ataacttgat caacgccatc   2580
 gccttactgg gcttttcaat cccggtgttc tggctggcgc ttctgttgac gctgttttgt   2640
 tcactcacgc tagggcgttt cgatctgctc tacgaagtga aaccgattac cggttttgcg   2700
 ttgattgatg cctggctttc ggactcacca tggcgggatg aaatgatcat gagcgcaatc   2760
 cgccatatga tattgcccgt gatcaccctg tcggttgcgc caacaactga agtgatccgc   2820
 ctgatgcgta tcagcactat cgaagtgtat gaccagaact atgtaaaagc ggcggcgacc   2880
 cgcggtttgt cgcgctttac tattttgcgt cgccacgttc tgcataacgc gttaccgccg   2940
 gttattcctc gcctgggctt acagttttcc accatgctga cgctggcgat gatcaccgaa   3000
 atggttttta gctggccggg tttaaagaat cgcattcccc gctctaacgc ctgtgcgccc   3060
 ttctgtgcca caggctccgc ctgtcctggc ctgccgcgcc gtctaacttc cgtcatacct   3120
 acggttaact ccgacctaca agcgtcacgc aaaacagagt tcctgttcag gaatactttc   3180
 aacatcacag ttgtcactgc cgccgcgatc gatggtcaga aaatcggtga cgcgctgcca   3240
 ggcgaaaagt gggtgatgcc agacgttacg atgcgtacag tcttgctcaa gaatctcaac   3300
 cagcgccaaa tcgtggtaac gctccaccag gccattgtta atatggaaaa aatcccgttg   3360
 ctgcgagcgg gccgtctgat tcattcgtac aaccccgggc tggcttgcga aacttatatg   3420
 gctcaagtct atggctggat gaccgttggc ttgttgctga ccgcatttgt tgcctggtat   3480
 gcggctaatt ccgcggccgt gatggagctg ttgttcacta accgtgtctt tttaatcggt   3540
 ctgatcatcg cgcaattagc attggttatt gtgttatcag cgatgattca aaagctgagc   3600
 gcaggtgtaa cgacgatgct ctttatgctt tattcggcgc tgacgggtct tacgctttcc   3660
 agtatattca ttgtctatac cgctgcttct atcgccagta ctttcgtcgt tactgccggg   3720
 atgttcggcg caatgagcct gtacggttac accacgaagc gcgatttaag tggctttggc   3780
 aatatgctgt ttatggcgtt aatcggcatt gtgctggcat cgctggtcaa cttctggttg   3840
 aaaagcgaag cattgatgtg ggcagttacc tacatcggcg tgattgtctt tgtcggattg   3900
 acggcgtatg acacgcagaa actgaaaaat atgggtgagc agattgatac ccgcgacacg   3960
 tatcccgcgt gctgttaa                                                 3978



      <210> 2476
      <211> 1054
      <212> DNA
      <213> Homo sapiens


      <400> 2476
 gtgcggtgga attccctggt gctctgggat ggtccttctc ttaggccctg aggggtgacc     60
 tcggggccat tcccaggatg ggccttcctc actggtaccc cacccctctc ccgccaggca    120
 tggccgcctt tgccaccgcc cacctcctct acgtctgggc cttcggcttc tctcccctgc    180
 agcccggcct gctgctgctc atcatcctgg cccctggccc ctacctcagc cttgtgctcc    240
 agcacctcga gccggatatg gtcctgccgg tggcagccta tgggctgatc ctgatggcca    300
 tgctgtggcg cggcctggcc cagggcggga gtgccggctg gggcgcgctg ctcttcacgc    360
 tctctgatgg cgtgctggcc tgggacacct tcgcccagcc cctgccccat gcccgcctgg    420
 tgatcatgac cacctactat gctgcccagc tcctcatcac actgtcagcc ctcaggagcc    480
 cggtgcccaa gactgactga ctagggagct tgaagggccg gtgttcaggc cctctcctcc    540
 tgcaaggacc tgggcctccc agcccagccc agcctgagaa ataccctcag cagcgaagct    600
 tcctgacgcc tgtctgcagg cgccgctgcc gccgtcgctt ctggctgaag acgtttgagg    660
 acgatttgcg gaattccaag tccactactg ggttccagct gccttccccc ggttctgact    720
 ccagatccct ggctcctcag ccaggcccac atggagccct cccagccacc agcctgcctc    780
 catgttcact gtcggcccca cagcctgccc gccccctgct gctgctctga atccgttttc    840
 cctgtgggtg tggaaccgta gatgttgctg ttaccgtagg agaggcctcg gggagggtca    900
 tcattgtgat aaaccatcgc ggttaatgac agcagaaggt tctttgtcgc tccccatgga    960
 ccaggcctgg tgcccagtgg gaccctccat ggccctctgg tggggggccc cggggggata   1020
 aagtgaggat tgtgcagaac tgaaaaaaaa aaaa                               1054



      <210> 2477
      <211> 2652
      <212> DNA
      <213> Homo sapiens


      <400> 2477
 atggagctga aaaccaaggc tagagaacta cgagaagaat gcagaagcct ccggagccga     60
 tgcaatcaac tggaagaaag gctatcagtg acggaagatg aaatgaatga aataaagcaa    120
 gaagggaagt ttagagaaaa aagaataaaa agaaacgaac aaagcctcca agaaatatgg    180
 gactatgtga aaagaccaaa tccccatgat acagataacc tgtgtctagg tccctctacc    240
 tttctggaag gatcagtatc agagttcacc tggagcacca gatggctggc aggagcaaag    300
 aaagacgaca ctcaaaatct gctcaagaat ttggagtcta atgcgcagac cccctcggaa    360
 actggctccc catcaaggag gaggaagaga gaagtgcaga tgtcgaagga caaggaagct    420
 gttgatgtcc caagttctta tcctgcgtcc aagaagaatg aagcacgcag acaagtggag    480
 gctttggctg aacttggggc ttgtatgggc ttcagagggg aggaagtgta tgccagttgg    540
 tccatggatg gccatgaatg gcctggaaaa ggcaccacaa gttcccactc tggtccgtgg    600
 gaccggcagc tgggccccca gcctacagat cctccctccc tgaaggaggg cctgaagagt    660
 ggtatcctgt ggcatgggta tagcacagtg tcttcaattg tccactggtt tagggacact    720
 tctgttgttt ccagagcctg cactgctcgc ctggtgccta atggcctcac agaatgtgag    780
 gaggaggaga aagagctgag actggcatcg tacctggcga ggatggccat ggtgcccggg    840
 gccacgcttc gccggctcct gagtgtggta ctgcccacag cctcacagcc tcagctgctg    900
 gccctgctgg attcggccac cgagagacat gtggaccacg cagctgagag cgatggcgga    960
 gcggagcagg ccgacgtggg caggcggaga aaaggaaaaa agaaaacact ttcagcaaca   1020
 gtttggggtc tgacacgtgg gataacattt ggtgcgattt ccaaccctcc aagcctggag   1080
 ctacaatcag ccctaactgc tgcacaggaa tgtgagccgc cttccaacag caatatcaca   1140
 gcattcgccc tgaaggccaa agtcatctac cccatcaatc agaagttccg gcctctggcc   1200
 gatggctcct ccaacccgtc tctgcatgaa aacttaaagc aggctgtttt gccacaccag   1260
 ccggtagagg cctctccttc cagcagtctg gggagcctga gccagggtga gaaggacgac   1320
 tgcagctcct catccagcgt ccactcggcc accagcgatg acaggtttct cagccgcacc   1380
 ttcctccggg tgaacgcctt ccctgaagtg ctggcctgcg agagtgtaga cgttgacctg   1440
 tgtatctaca gccttcactt aaaagacctg ctgcatttgg acacggcact gaggcaggaa   1500
 aagcatatgg taggtggaga tgttcgcatt ccctcctttt catggggaca ggagctggga   1560
 gacaaggact ctgtgtgcac ccctccagag gtcatttcag tacagcaggg tccaaggcac   1620
 ccatcacaac tcattggcat cagctatctg gtgtctgggt cgagtgaagc acagacagcc   1680
 cgcatatggc tgcttgttaa caacaccaag acaacctcgt cagccaacct ctcggagctg   1740
 ctcttgctgg acagcattgc tggtctcacc atttgggact ctgtgggaaa caggacctcg   1800
 gaaggattcc aggcttttag caagaagttt ctgcaagggt acctggatga agaccaaatg   1860
 gaaatgctat tggagcgggc tcagacagaa gtcttttcaa tcaagcagaa gttggacaat   1920
 gacttaaagc aggaaaagaa aaagctccac caaaaattaa taactaagag aagacgagag   1980
 ttgctacaaa agcacaggga gcagcgtagg gagcaggcgt ccgtcggcga ggccttccga   2040
 acggttgagg atgccggcca gtacctgcac cagaagagga gcctgatgga ggagcacggt   2100
 gccaccctgg aggagctgca ggagcgtctg gaccaggccg ccctggacga tctcaggacc   2160
 ctgacccttt cgctgtttga aaaggccacc gacgagctgc ggcgcctgca gaactcagcc   2220
 atgacccagg agctgctcaa gcgtggggtg ccctggctct tcctgcagca gatcctggag   2280
 gagcacggca aggagatggc tgcacgggcc gagcagctgg agggggagga gagggacagg   2340
 gaccaggagg gtgtccagag cgtgaggcag agactgaagg atgacgctcc tgaggccgtg   2400
 acagaggagc aggcagagct gcgacgctgg gagcacctga tcttcatgaa gctctgctcc   2460
 tcagtcttct ccctgtctga agaggagctg ctcaggatga ggcaggaggt ccatggctgc   2520
 tttgctcaga tggacaggag cttggccctc cccaagatcc gggcccgagt tctgctgcag   2580
 caatttcaga ctgcgtggcg agaagcagag ttcgtgaagc tggaccaggc cgtggctgcc   2640
 cctgagctgc ag                                                       2652



      <210> 2478
      <211> 499
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> misc_feature
      <222> (1)...(499)
      <223> n = a,t,c or g


      <400> 2478
 agcggtggaa ttgatccctn nnnnnnnnta tcgatttctc ttgtgcagtg tcgtggaatt     60
 cctttgattc tctgctttca aaacttgtga gtaagattca gagatagtgt cttgcaatgt    120
 cgcccaggct ggagtgcagt ggtgcccctc ctgttgtgaa tgtatctcct gatctgttta    180
 actcctgtgt gtgaaacttt gtgattcatg caatgagaac aaggctttac gtgaacagac    240
 cagagcccag gtgcagggcg gtcattccag agcccaggtg cagcaggtgc agggcggtca    300
 ttctgcccac acagtggttc agatccgttc agcagccagc cgccggaagg ccttctccac    360
 ctgttcttcc cacctgggca tggtgctcct gttctatggc accggcagct ccacctacat    420
 gcgacccacc acccgctact ccccgctgga agggcgcttg gctgctgtct tctactccat    480
 cctcataccc accctgaat                                                 499



      <210> 2479
      <211> 126
      <212> PRT
      <213> Homo sapiens


      <400> 2479
 Asp Asp Gly Gly Asn Gln Asp Gly Leu Trp Ala Asp Pro Asp Pro Ser
   1               5                  10                  15    
 Leu Cys Leu Ser Ala His Gln Ile Ile Ile Pro Val Phe Leu Gly Glu
              20                  25                  30        
 Ser Val Pro Pro Glu Met Leu Ala Ala Thr Leu Ala Glu Leu Asp Gly
          35                  40                  45            
 Cys Leu Gln Leu Leu Glu Asp Lys Phe Leu Arg Asp Gln Ala Phe Leu
      50                  55                  60                
 Thr Gly Pro Arg Ile Ser Val Ala Gly Leu Val Ala Ile Thr Glu Leu
  65                  70                  75                  80
 Arg His Glu Ser Ala Met Gly Cys Gly Gly Pro Leu Gly Ser Gly Val
                  85                  90                  95    
 Ser Gly Lys Gly Ala Asp Ile Pro Ala His Val Val Phe Ser Gly Cys
             100                 105                 110        
 Gly Thr Leu Cys Glu Ser Leu Leu Leu Leu Ser Leu Glu Phe
         115                 120                 125    



      <210> 2480
      <211> 730
      <212> PRT
      <213> Homo sapiens


      <400> 2480
 Met Ser Cys Asp Thr Asn Gly Glu Val Glu Gly Gly Arg Val Asp Ser
   1               5                  10                  15    
 Lys Thr Arg Gly Arg Gln Glu Val Glu Arg Asn Thr Glu Thr His Leu
              20                  25                  30        
 Gly Ser Gly Leu Asn Cys Asp Ile Pro Leu Ile Phe Leu Thr Tyr Glu
          35                  40                  45            
 Trp Arg Gly Ile Leu Glu Tyr Lys Ile Phe Ser Val Lys Thr Gly Glu
      50                  55                  60                
 Val Leu Gly Lys Pro Gly Gln Leu Gly His Pro Thr Gly Gln Thr Thr
  65                  70                  75                  80
 Phe Phe Glu Thr Gly Thr Gln Val Thr Ser Met Gln Glu Met Gly Ser
                  85                  90                  95    
 Tyr Ser Phe Gly Gln Pro His Pro Val Ala Leu Gln Gly Thr Ala Pro
             100                 105                 110        
 Leu Pro Ala Ala Phe Thr Gly Trp Arg Leu Ala Ser Val Ala Phe Pro
         115                 120                 125            
 Gly Thr Gln Cys Lys Leu Ser Val Asp Leu Pro Ile Trp Gly Leu Glu
     130                 135                 140                
 Asp Ser Gly Pro Leu Leu Thr Ala Pro Leu Gly Ser Ala Pro Val Gly
 145                 150                 155                 160
 Pro Leu Cys Gly Gly Ser Asp Pro Thr Phe Pro Phe Cys Thr Ala Leu
                 165                 170                 175    
 Thr Gly Pro Ser Ala Ala Ser Leu Leu Glu Phe Ala Arg Gly Pro Leu
             180                 185                 190        
 Gln Thr Leu Phe Ala Trp Val Ser Ala Glu Val Ser Ala Glu Gln Gly
         195                 200                 205            
 Phe Phe Val Asn His Glu Cys Cys Cys Leu Ile Val Pro Leu Glu Val
     210                 215                 220                
 Leu Ser Gln Arg Ser Thr Arg Pro Cys Glu Val Ser Val Cys Pro Tyr
 225                 230                 235                 240
 Trp Gly Val Pro Pro Arg Asp Arg Ser Asn Gln Cys Pro Ser Gly Phe
                 245                 250                 255    
 Thr Leu Asp Ser Val Gly Pro Phe Cys Ala Asp Glu Asp Glu Cys Ala
             260                 265                 270        
 Ala Gly Asn Pro Cys Ser His Ser Cys His Asn Ala Met Gly Thr Tyr
         275                 280                 285            
 Tyr Cys Ser Cys Pro Lys Gly Leu Thr Ile Ala Ala Asp Gly Arg Thr
     290                 295                 300                
 Cys Gln Asp Ile Asp Glu Cys Ala Leu Gly Arg His Thr Cys His Ala
 305                 310                 315                 320
 Gly Gln Asp Cys Asp Asn Thr Ile Gly Ser Tyr Arg Cys Val Val Arg
                 325                 330                 335    
 Cys Gly Ser Gly Phe Arg Arg Thr Ser Asp Gly Leu Ser Cys Gln Asp
             340                 345                 350        
 Ile Asn Glu Cys Gln Glu Ser Ser Pro Cys His Gln Arg Cys Phe Asn
         355                 360                 365            
 Ala Ile Gly Ser Phe His Cys Gly Cys Glu Pro Gly Tyr Gln Leu Lys
     370                 375                 380                
 Gly Arg Lys Cys Met Asp Val Asn Glu Cys Arg Gln Asn Val Cys Arg
 385                 390                 395                 400
 Pro Asp Gln His Cys Lys Asn Thr Arg Gly Gly Tyr Lys Cys Ile Asp
                 405                 410                 415    
 Leu Cys Pro Asn Gly Met Thr Lys Ala Glu Asn Gly Thr Cys Ile Gly
             420                 425                 430        
 Glu Cys Leu Ala Val Ser Val Thr Glu Ile Ser Leu Pro Ser Thr Ser
         435                 440                 445            
 Gln Ile Leu Met Asn Val Lys Met Gly Pro Ile Ser Ala Asp Ile Thr
     450                 455                 460                
 Arg Tyr Val Arg Ile Gln Glu Ala Ala Ile Val Val Tyr Ala Gln Glu
 465                 470                 475                 480
 Val Ile Gly Leu Lys Glu Leu Glu Asp Pro Ala Trp Ile Leu Met Asn
                 485                 490                 495    
 Val Lys Ile Gln Met Pro Ala Ser Met Ser Val Arg Ile Pro Leu Glu
             500                 505                 510        
 Val Ile Ser Ala Ser Ala His Leu Ala Ile Asn Ser His Thr Met Glu
         515                 520                 525            
 Arg His Ala Lys Glu Asn Cys His Leu Asn Lys Leu Lys Val Gly Gly
     530                 535                 540                
 Ala Ser Lys Glu Lys Glu Lys Ser Asp Asp Phe Leu Glu Lys Gly Glu
 545                 550                 555                 560
 Lys Asn Leu Gly Ile Ile Lys Val Thr Lys Arg Val Ala Asn Val Leu
                 565                 570                 575    
 Met Leu Trp Lys Ser Leu Asp Ser Ile His Leu Asp Pro Phe Gly Thr
             580                 585                 590        
 Ser Val Asn Tyr Leu Asp Ser Ala Phe Arg Asn Ile Arg Asn Leu Gly
         595                 600                 605            
 Ile Val Ser Val Thr Ser Thr Asp Ile Ser Ser Leu Tyr Ala Lys Ala
     610                 615                 620                
 Gln His Val Ala Arg Arg His Tyr Gly Cys Asn Ile Val Arg Thr Glu
 625                 630                 635                 640
 Tyr Tyr Lys Glu Leu Ala Ala Arg Ile Val Val Ala Ala Val Ala Ser
                 645                 650                 655    
 Val Ser Val Glu Phe Ala Gly Ser Glu Asp Cys His Ser Asn Ile Gln
             660                 665                 670        
 Asp Glu Gly Leu Leu Leu Ala Ala Leu Leu Asp Val Met Lys Glu Gly
         675                 680                 685            
 Phe Pro Thr Leu Pro Cys Ile Leu Arg Glu Leu Ser Gly Leu Val Ile
     690                 695                 700                
 Asp Leu Ile Ala Tyr Leu Cys Ser Thr Thr Gly Met Leu Lys Ile Asn
 705                 710                 715                 720
 Phe Lys Glu Met Leu Ser Glu Val Leu Gly
                 725                 730



      <210> 2481
      <211> 127
      <212> PRT
      <213> Homo sapiens


      <400> 2481
 Gly Ala Val Ser Val Pro Leu Pro Ala Met Pro Phe Leu Glu Leu Asp
   1               5                  10                  15    
 Thr Asn Leu Pro Ala Asn Arg Val Pro Ala Gly Leu Glu Lys Arg Leu
              20                  25                  30        
 Cys Ala Ala Ala Ala Ser Ile Leu Gly Lys Pro Ala Asp Arg Val Asn
          35                  40                  45            
 Val Thr Val Arg Pro Gly Leu Ala Met Ala Leu Ser Gly Ser Thr Glu
      50                  55                  60                
 Pro Cys Ala Gln Leu Ser Ile Ser Ser Ile Gly Val Val Gly Thr Ala
  65                  70                  75                  80
 Glu Asp Asn Arg Ser His Ser Ala His Phe Phe Glu Phe Leu Thr Lys
                  85                  90                  95    
 Glu Leu Ala Leu Gly Gln Asp Arg Ile Leu Ile Arg Phe Phe Pro Leu
             100                 105                 110        
 Glu Ser Trp Gln Ile Gly Lys Ile Gly Thr Val Met Thr Phe Leu
         115                 120                 125        



      <210> 2482
      <211> 127
      <212> PRT
      <213> Homo sapiens


      <400> 2482
 Gly Ala Val Ser Val Pro Leu Pro Ala Met Pro Phe Leu Glu Leu Asp
   1               5                  10                  15    
 Thr Asn Leu Pro Ala Asn Arg Val Pro Ala Gly Leu Glu Lys Arg Leu
              20                  25                  30        
 Cys Ala Ala Ala Ala Ser Ile Leu Gly Lys Pro Ala Asp Arg Val Asn
          35                  40                  45            
 Val Thr Val Arg Pro Gly Leu Ala Met Ala Leu Ser Gly Ser Thr Glu
      50                  55                  60                
 Pro Cys Ala Gln Leu Ser Ile Ser Ser Ile Gly Val Val Gly Thr Ala
  65                  70                  75                  80
 Glu Asp Asn Arg Ser His Ser Ala His Phe Phe Glu Phe Leu Thr Lys
                  85                  90                  95    
 Glu Leu Ala Leu Gly Gln Asp Arg Ile Leu Ile Arg Phe Phe Pro Leu
             100                 105                 110        
 Glu Ser Trp Gln Ile Gly Lys Ile Gly Thr Val Met Thr Phe Leu
         115                 120                 125        



      <210> 2483
      <211> 885
      <212> PRT
      <213> Homo sapiens


      <400> 2483
 Cys Lys Cys His Pro Gln Gly Ser Val Gly Ser Ser Cys Ser Arg Leu
   1               5                  10                  15    
 Gly Gly Gln Cys Gln Cys Lys Pro Leu Val Val Gly Arg Cys Cys Asp
              20                  25                  30        
 Arg Cys Ser Thr Gly Ser Tyr Asp Leu Gly His His Gly Cys His Pro
          35                  40                  45            
 Cys His Cys His Pro Gln Gly Ser Lys Asp Thr Val Cys Asp Gln Val
      50                  55                  60                
 Thr Gly Gln Cys Pro Cys His Gly Glu Val Ser Gly Arg Arg Cys Asp
  65                  70                  75                  80
 Arg Cys Leu Ala Gly Tyr Phe Gly Phe Pro Ser Cys His Pro Cys Pro
                  85                  90                  95    
 Cys Asn Arg Phe Ala Glu Leu Cys Asp Pro Glu Thr Gly Ser Cys Phe
             100                 105                 110        
 Asn Cys Gly Gly Phe Thr Thr Gly Arg Asn Cys Glu Arg Cys Ile Asp
         115                 120                 125            
 Gly Tyr Tyr Gly Asn Pro Ser Ser Gly Gln Pro Cys Arg Pro Cys Leu
     130                 135                 140                
 Cys Pro Asp Asp Pro Ser Ser Asn Gln Tyr Phe Ala His Ser Cys Tyr
 145                 150                 155                 160
 Gln Asn Leu Trp Ser Ser Asp Val Ile Cys Asn Cys Leu Gln Gly Tyr
                 165                 170                 175    
 Thr Gly Thr Gln Cys Gly Glu Cys Ser Thr Gly Phe Tyr Gly Asn Pro
             180                 185                 190        
 Arg Ile Ser Gly Ala Pro Cys Gln Pro Cys Ala Cys Asn Asn Asn Ile
         195                 200                 205            
 Asp Val Thr Asp Pro Glu Ser Cys Ser Arg Val Thr Gly Glu Cys Leu
     210                 215                 220                
 Arg Cys Leu His Asn Thr Gln Gly Ala Asn Cys Gln Leu Cys Lys Pro
 225                 230                 235                 240
 Gly His Tyr Gly Ser Ala Leu Asn Gln Thr Cys Arg Arg Cys Ser Cys
                 245                 250                 255    
 His Ala Ser Gly Val Ser Pro Met Glu Cys Pro Pro Gly Gly Gly Ala
             260                 265                 270        
 Cys Leu Cys Asp Pro Val Thr Gly Ala Cys Pro Cys Leu Pro Asn Val
         275                 280                 285            
 Thr Gly Leu Ala Cys Asp Arg Cys Ala Asp Gly Tyr Trp Asn Leu Val
     290                 295                 300                
 Pro Gly Arg Gly Ser Cys Asp Cys Asn Arg Ala Gly Thr Gln Lys Pro
 305                 310                 315                 320
 Ile Cys Asp Pro Asp Thr Gly Met Cys Arg Cys Arg Glu Gly Val Ser
                 325                 330                 335    
 Gly Gln Arg Cys Asp Arg Cys Ala Arg Gly His Ser Gln Glu Phe Pro
             340                 345                 350        
 Thr Cys Leu Gln Cys His Leu Cys Phe Asp Gln Trp Asp His Thr Ile
         355                 360                 365            
 Ser Ser Leu Ser Lys Ala Val Gln Gly Leu Met Arg Leu Ala Ala Asn
     370                 375                 380                
 Met Glu Asp Lys Arg Glu Thr Leu Pro Val Cys Glu Ala Asp Phe Lys
 385                 390                 395                 400
 Asp Leu Arg Gly Asn Val Ser Glu Ile Glu Arg Ile Leu Lys His Pro
                 405                 410                 415    
 Val Phe Pro Ser Gly Lys Phe Leu Lys Val Lys Asp Tyr His Asp Ser
             420                 425                 430        
 Val Arg Arg Gln Ile Met Gln Leu Asn Glu Gln Leu Lys Ala Val Tyr
         435                 440                 445            
 Glu Phe Gln Asp Leu Lys Asp Thr Ile Glu Arg Ala Lys Asn Glu Ala
     450                 455                 460                
 Asp Leu Leu Leu Glu Asp Leu Gln Glu Glu Ile Asp Leu Gln Ser Ser
 465                 470                 475                 480
 Val Leu Asn Ala Ser Ile Ala Asp Ser Ser Glu Asn Ile Lys Lys Tyr
                 485                 490                 495    
 Tyr His Ile Ser Ser Ser Ala Glu Lys Lys Ile Asn Glu Thr Ser Ser
             500                 505                 510        
 Thr Ile Asn Thr Ser Ala Asn Thr Arg Asn Asp Leu Leu Thr Ile Leu
         515                 520                 525            
 Asp Thr Leu Thr Ser Lys Gly Asn Leu Ser Leu Glu Arg Leu Lys Gln
     530                 535                 540                
 Ile Lys Ile Pro Asp Ile Gln Ile Leu Asn Glu Lys Val Cys Gly Asp
 545                 550                 555                 560
 Pro Gly Asn Val Pro Cys Val Pro Leu Pro Cys Gly Gly Ala Leu Cys
                 565                 570                 575    
 Thr Gly Arg Lys Gly His Arg Lys Cys Arg Gly Pro Gly Cys His Gly
             580                 585                 590        
 Ser Leu Thr Leu Ser Thr Asn Ala Leu Gln Lys Ala Gln Glu Ala Lys
         595                 600                 605            
 Ser Ile Ile Arg Asn Leu Asp Lys Gln Val Arg Gly Leu Lys Asn Gln
     610                 615                 620                
 Ile Glu Ser Ile Ser Glu Gln Ala Glu Val Ser Lys Asn Asn Ala Leu
 625                 630                 635                 640
 Gln Leu Arg Glu Lys Leu Gly Asn Ile Arg Asn Gln Ser Asp Ser Glu
                 645                 650                 655    
 Glu Glu Asn Ile Asn Leu Phe Ile Lys Lys Val Lys Asn Phe Leu Leu
             660                 665                 670        
 Glu Glu Asn Val Pro Pro Glu Asp Ile Glu Lys Val Ala Asn Gly Val
         675                 680                 685            
 Leu Asp Ile His Leu Pro Ile Pro Ser Gln Asn Leu Thr Asp Glu Leu
     690                 695                 700                
 Val Lys Ile Gln Lys His Met Gln Leu Cys Glu Asp Tyr Arg Thr Asp
 705                 710                 715                 720
 Glu Asn Arg Leu Asn Glu Glu Ala Asp Gly Ala Gln Lys Leu Leu Val
                 725                 730                 735    
 Lys Ala Lys Ala Ala Glu Lys Ala Ala Asn Ile Leu Leu Asn Leu Asp
             740                 745                 750        
 Lys Thr Leu Asn Gln Leu Gln Gln Ala Gln Ile Thr Gln Gly Arg Ala
         755                 760                 765            
 Asn Ser Thr Ile Thr Gln Leu Thr Ala Asn Ile Thr Lys Ile Lys Lys
     770                 775                 780                
 Asn Val Leu Gln Glu Phe Val Glu Leu Lys Lys Gln Tyr Ala Ile Leu
 785                 790                 795                 800
 Gln Arg Lys Thr Ser Thr Thr Gly Leu Thr Lys Glu Thr Leu Gly Lys
                 805                 810                 815    
 Val Lys Gln Leu Lys Asp Ala Ala Glu Lys Leu Ala Gly Asp Thr Glu
             820                 825                 830        
 Ala Lys Ile Arg Arg Ile Thr Asp Leu Glu Ser Lys Ile Gln Asp Leu
         835                 840                 845            
 Asn Leu Ser Arg Gln Ala Lys Ala Asp Gln Leu Arg Ile Leu Glu Asp
     850                 855                 860                
 Gln Val Val Ala Ile Lys Asn Glu Ile Val Glu Gln Glu Lys Lys Tyr
 865                 870                 875                 880
 Ala Arg Cys Tyr Ser
                 885



      <210> 2484
      <211> 897
      <212> PRT
      <213> Homo sapiens


      <400> 2484
 Met Gly Ser Gly Arg Val Pro Gly Leu Cys Leu Leu Val Leu Leu Val
   1               5                  10                  15    
 His Ala Arg Ala Ala Gln Tyr Ser Lys Ala Ala Gln Asp Val Asp Glu
              20                  25                  30        
 Cys Val Glu Gly Thr Asp Asn Cys His Ile Asp Ala Ile Cys Gln Asn
          35                  40                  45            
 Thr Pro Arg Ser Tyr Lys Cys Ile Cys Lys Ser Gly Tyr Thr Gly Asp
      50                  55                  60                
 Gly Lys His Cys Lys Asp Val Asp Glu Cys Glu Arg Glu Asp Asn Ala
  65                  70                  75                  80
 Gly Cys Val His Asp Cys Val Asn Ile Pro Gly Asn Tyr Arg Cys Thr
                  85                  90                  95    
 Cys Tyr Asp Gly Phe His Leu Ala His Asp Gly His Asn Cys Leu Asp
             100                 105                 110        
 Val Asp Glu Cys Ala Glu Gly Asn Gly Gly Cys Gln Gln Ser Cys Val
         115                 120                 125            
 Asn Met Met Gly Ser Tyr Glu Cys His Cys Arg Glu Gly Phe Phe Leu
     130                 135                 140                
 Ser Asp Asn Gln His Thr Cys Ile Gln Arg Pro Glu Glu Gly Met Asn
 145                 150                 155                 160
 Cys Met Asn Lys Asn His Gly Cys Ala His Ile Cys Arg Glu Thr Pro
                 165                 170                 175    
 Lys Gly Gly Ile Ala Cys Glu Cys Arg Pro Gly Phe Glu Leu Thr Lys
             180                 185                 190        
 Asn Gln Arg Asp Cys Lys Cys Glu Ile Ile Gly Met Ala Val Thr Cys
         195                 200                 205            
 Asn Tyr Gly Asn Gly Gly Cys Gln His Thr Cys Asp Asp Thr Glu Gln
     210                 215                 220                
 Gly Pro Arg Cys Gly Cys His Ile Lys Phe Val Leu His Thr Asp Gly
 225                 230                 235                 240
 Lys Thr Cys Ile Glu Thr Cys Ala Val Asn Asn Gly Gly Cys Asp Ser
                 245                 250                 255    
 Lys Cys His Asp Ala Ala Thr Gly Val His Cys Thr Cys Pro Val Gly
             260                 265                 270        
 Phe Met Leu Gln Pro Asp Arg Lys Thr Cys Lys Asp Ile Asp Glu Cys
         275                 280                 285            
 Arg Leu Asn Asn Gly Gly Cys Asp His Ile Cys Arg Asn Thr Val Gly
     290                 295                 300                
 Ser Phe Glu Cys Ser Cys Lys Lys Gly Tyr Lys Leu Leu Ile Asn Glu
 305                 310                 315                 320
 Arg Asn Cys Gln Asp Ile Asp Glu Cys Ser Phe Asp Arg Thr Cys Asp
                 325                 330                 335    
 His Ile Cys Val Asn Thr Pro Gly Ser Phe Gln Cys Leu Cys His Arg
             340                 345                 350        
 Gly Tyr Leu Leu Tyr Gly Ile Thr His Cys Gly Asp Val Asp Glu Cys
         355                 360                 365            
 Ser Ile Asn Arg Gly Gly Cys Arg Phe Gly Cys Ile Asn Thr Pro Gly
     370                 375                 380                
 Ser Tyr Gln Cys Thr Cys Pro Ala Gly Gln Gly Arg Leu His Trp Asn
 385                 390                 395                 400
 Gly Lys Asp Cys Thr Glu Pro Leu Lys Cys Gln Gly Ser Pro Gly Ala
                 405                 410                 415    
 Ser Lys Ala Met Leu Ser Cys Asn Arg Ser Gly Lys Lys Asp Thr Cys
             420                 425                 430        
 Ala Leu Thr Cys Pro Ser Arg Ala Arg Phe Leu Pro Glu Ser Glu Asn
         435                 440                 445            
 Gly Phe Thr Val Ser Cys Gly Thr Pro Ser Pro Arg Ala Ala Pro Ala
     450                 455                 460                
 Arg Ala Gly His Asn Gly Asn Ser Thr Asn Ser Asn His Cys His Glu
 465                 470                 475                 480
 Ala Ala Val Leu Ser Ile Lys Gln Arg Ala Ser Phe Lys Ile Lys Asp
                 485                 490                 495    
 Ala Lys Cys Arg Leu His Leu Arg Asn Lys Gly Lys Thr Glu Glu Ala
             500                 505                 510        
 Gly Arg Ile Thr Gly Pro Gly Gly Ala Pro Cys Ser Glu Cys Gln Val
         515                 520                 525            
 Thr Phe Ile His Leu Lys Cys Asp Ser Ser Arg Lys Gly Lys Gly Arg
     530                 535                 540                
 Arg Ala Arg Thr Pro Pro Gly Lys Glu Val Thr Arg Leu Thr Leu Glu
 545                 550                 555                 560
 Leu Glu Ala Glu Gln Leu Phe Leu Leu Pro Asp Thr His Gly His Pro
                 565                 570                 575    
 Pro Pro Ala Ser Cys Gly Leu Pro Cys Leu Arg Gln Arg Met Glu Arg
             580                 585                 590        
 Arg Leu Lys Gly Ser Leu Lys Met Leu Arg Lys Ser Ile Asn Gln Asp
         595                 600                 605            
 Arg Phe Leu Leu Arg Leu Ala Gly Leu Asp Tyr Glu Leu Ala His Lys
     610                 615                 620                
 Pro Gly Leu Val Ala Gly Glu Arg Ala Glu Pro Met Glu Ser Cys Arg
 625                 630                 635                 640
 Pro Gly Gln His Arg Ala Gly Thr Lys Cys Val Gln Cys Ser Pro Gly
                 645                 650                 655    
 His Tyr Tyr Asn Thr Ser Ile His Arg Cys Ile Arg Cys Ala Met Gly
             660                 665                 670        
 Ser Tyr Gln Pro Asp Phe Arg Gln Asn Phe Cys Ser Arg Cys Pro Gly
         675                 680                 685            
 Asn Thr Ser Thr Asp Phe Asp Gly Ser Thr Ser Val Ala Gln Cys Lys
     690                 695                 700                
 Asn Arg Gln Cys Gly Gly Glu Leu Gly Glu Phe Thr Gly Tyr Ile Glu
 705                 710                 715                 720
 Ser Pro Asn Tyr Pro Gly Asn Tyr Pro Ala Gly Val Glu Cys Ile Trp
                 725                 730                 735    
 Asn Ile Asn Pro Pro Pro Lys Arg Lys Ile Leu Ile Val Val Pro Glu
             740                 745                 750        
 Ile Phe Leu Pro Ser Glu Asp Glu Cys Gly Asp Val Leu Val Met Arg
         755                 760                 765            
 Lys Asn Ser Ser Pro Ser Ser Ile Thr Thr Tyr Glu Thr Cys Gln Thr
     770                 775                 780                
 Tyr Glu Arg Pro Ile Ala Phe Thr Ala Arg Ser Arg Lys Leu Trp Ile
 785                 790                 795                 800
 Asn Phe Lys Thr Ser Glu Ala Asn Ser Ala Arg Gly Phe Gln Ile Pro
                 805                 810                 815    
 Tyr Val Thr Tyr Asp Glu Asp Tyr Glu Gln Leu Val Glu Asp Ile Val
             820                 825                 830        
 Arg Asp Gly Arg Leu Tyr Ala Ser Glu Asn His Gln Glu Ile Leu Lys
         835                 840                 845            
 Asp Lys Lys Leu Ile Lys Ala Phe Phe Glu Val Leu Ala His Pro Gln
     850                 855                 860                
 Asn Tyr Phe Lys Tyr Thr Glu Lys His Lys Glu Met Leu Pro Lys Ser
 865                 870                 875                 880
 Phe Ile Lys Leu Leu Arg Ser Lys Val Ser Ser Phe Leu Arg Pro Tyr
                 885                 890                 895    
 Lys
    



      <210> 2485
      <211> 186
      <212> PRT
      <213> Homo sapiens


      <400> 2485
 Asn Leu Phe Ser Gly Cys Val Glu Ser Thr Phe Arg Lys Gln Pro Ala
   1               5                  10                  15    
 His Gln Arg Arg Ser Arg Ala Arg Ala Glu Thr Met Gln Arg Arg Leu
              20                  25                  30        
 Val Gln Gln Trp Ser Val Ala Val Phe Leu Leu Ser Tyr Ala Val Pro
          35                  40                  45            
 Ser Cys Gly Arg Ser Val Glu Gly Leu Ser Arg Arg Leu Lys Arg Ala
      50                  55                  60                
 Val Ser Glu His Gln Leu Leu His Asp Lys Gly Lys Ser Ile Gln Asp
  65                  70                  75                  80
 Leu Arg Arg Arg Phe Phe Leu His His Leu Ile Ala Glu Ile His Thr
                  85                  90                  95    
 Ala Glu Ile His Pro Val Arg Phe Gly Ser Asp Asp Glu Gly Arg Tyr
             100                 105                 110        
 Leu Thr Gln Glu Thr Asn Lys Val Glu Thr Tyr Lys Glu Gln Pro Leu
         115                 120                 125            
 Lys Thr Pro Gly Lys Lys Lys Lys Gly Lys Pro Gly Lys Arg Lys Glu
     130                 135                 140                
 Gln Glu Lys Lys Lys Arg Arg Thr Arg Ser Ala Trp Leu Asp Ser Gly
 145                 150                 155                 160
 Val Thr Gly Ser Gly Leu Glu Gly Asp His Leu Ser Asp Thr Ser Thr
                 165                 170                 175    
 Thr Ser Leu Glu Leu Asp Ser Arg Arg His
             180                 185    



      <210> 2486
      <211> 208
      <212> PRT
      <213> Homo sapiens


      <400> 2486
 Pro Gly Ser Thr Ile Ser Cys Tyr Arg Gln Val Tyr Thr Thr Glu Ala
   1               5                  10                  15    
 Arg Thr Val Leu Arg Cys Cys Arg Gly Trp Met Gln Gln Pro Asp Glu
              20                  25                  30        
 Glu Gly Cys Leu Ser Ala Glu Cys Ser Ala Ser Leu Cys Phe His Gly
          35                  40                  45            
 Gly Arg Cys Val Pro Gly Ser Ala Gln Pro Cys His Cys Pro Pro Gly
      50                  55                  60                
 Phe Gln Gly Pro Arg Cys Gln Tyr Asp Val Asp Glu Cys Arg Thr His
  65                  70                  75                  80
 Asn Gly Gly Cys Gln His Arg Cys Val Asn Thr Pro Gly Ser Tyr Leu
                  85                  90                  95    
 Cys Glu Cys Lys Pro Gly Phe Arg Leu His Thr Asp Ser Arg Ser Cys
             100                 105                 110        
 Leu Ala Ile Asn Ser Cys Ala Leu Gly Asn Gly Gly Cys Gln His His
         115                 120                 125            
 Cys Val Gln Leu Thr Ile Thr Arg His Arg Cys Gln Cys Arg Pro Gly
     130                 135                 140                
 Phe Gln Leu Gln Glu Asp Gly Arg His Cys Val Arg Arg Ser Pro Cys
 145                 150                 155                 160
 Ala Asn Arg Asn Gly Ser Cys Met His Arg Cys Gln Val Val Arg Gly
                 165                 170                 175    
 Leu Ala Arg Cys Glu Cys His Val Gly Tyr Gln Leu Ala Ala Asp Gly
             180                 185                 190        
 Lys Ala Cys Glu Asp Val Asp Glu Cys Ala Ala Arg Leu Ala Gln Cys
         195                 200                 205            





      <210> 2487
      <211> 94
      <212> PRT
      <213> Homo sapiens


      <400> 2487
 Ser Ser His Gln Ala Ser Ser Pro Pro Thr Thr Ala Ser His Ser Met
   1               5                  10                  15    
 Lys Ile Ser Val Ala Ala Ile Pro Phe Phe Leu Leu Ile Thr Ile Thr
              20                  25                  30        
 Leu Gly Thr Lys Thr Glu Ser Ser Ser Arg Gly Pro Tyr His Pro Ser
          35                  40                  45            
 Glu Cys Cys Phe Thr Tyr Thr Thr Tyr Lys Ile Pro Ala Gln Arg Ile
      50                  55                  60                
 Met Asp Tyr Tyr Glu Thr Asn Ser Gln Cys Phe Lys Pro Gly Ile Val
  65                  70                  75                  80
 Phe Ile Thr Lys Arg Gly His Ser Arg Trp Thr Asn Pro Lys
                  85                  90                



      <210> 2488
      <211> 137
      <212> PRT
      <213> Homo sapiens


      <400> 2488
 Met Lys Ala Leu Leu Ala Leu Pro Leu Leu Leu Leu Leu Ser Thr Pro
   1               5                  10                  15    
 Pro Cys Ala Pro Gln Val Ser Gly Ile Arg Gly Asp Ala Leu Glu Arg
              20                  25                  30        
 Phe Cys Leu Gln Gln Pro Leu Asp Cys Asp Asp Ile Tyr Ala Gln Gly
          35                  40                  45            
 Tyr Gln Ser Asp Gly Val Tyr Leu Ile Tyr Pro Ser Gly Pro Ser Val
      50                  55                  60                
 Pro Val Pro Val Phe Cys Asp Met Thr Thr Glu Gly Gly Lys Trp Thr
  65                  70                  75                  80
 Val Phe Gln Lys Arg Phe Asn Gly Ser Val Ser Phe Phe Arg Gly Trp
                  85                  90                  95    
 Asn Asp Tyr Lys Leu Gly Phe Gly Arg Ala Asp Gly Glu Tyr Trp Leu
             100                 105                 110        
 Gly Leu Gln Asn Met His Leu Leu Thr Leu Lys Gln Lys Tyr Glu Leu
         115                 120                 125            
 Arg Val Asp Leu Glu Asp Phe Glu Asn
     130                 135        



      <210> 2489
      <211> 258
      <212> PRT
      <213> Homo sapiens


      <400> 2489
 Trp Gly Ser Arg Ala Met Ser Asp Leu Leu Leu Leu Gly Leu Ile Gly
   1               5                  10                  15    
 Gly Leu Thr Leu Leu Leu Leu Leu Thr Leu Leu Ala Phe Ala Gly Val
              20                  25                  30        
 Pro Pro Asp Lys Cys Arg Cys Ala Val Gly Ser Ile Leu Ser Glu Gly
          35                  40                  45            
 Glu Glu Ser Pro Ser Pro Glu Leu Ile Asp Leu Tyr Gln Lys Phe Gly
      50                  55                  60                
 Phe Lys Val Phe Ser Phe Pro Ala Pro Ser His Val Val Thr Ala Thr
  65                  70                  75                  80
 Phe Pro Tyr Thr Thr Ile Leu Ser Ile Trp Leu Ala Thr Arg Arg Val
                  85                  90                  95    
 His Pro Ala Leu Asp Thr Tyr Ile Lys Glu Arg Lys Leu Cys Ala Tyr
             100                 105                 110        
 Pro Arg Leu Glu Ile Tyr Gln Glu Asp Gln Ile His Phe Met Cys Pro
         115                 120                 125            
 Leu Ala Arg Gln Gly Asp Phe Tyr Val Pro Glu Met Lys Glu Thr Glu
     130                 135                 140                
 Trp Lys Trp Arg Gly Leu Val Glu Ala Ile Asp Thr Gln Val Asp Gly
 145                 150                 155                 160
 Thr Gly Ala Asp Thr Met Ser Asp Thr Ser Ser Val Ser Leu Glu Val
                 165                 170                 175    
 Ser Pro Gly Ser Arg Glu Thr Ser Ala Ala Thr Leu Ser Pro Gly Ala
             180                 185                 190        
 Ser Ser Arg Gly Trp Asp Asp Gly Asp Thr Arg Ser Glu His Ser Tyr
         195                 200                 205            
 Ser Glu Ser Gly Ala Ser Gly Ser Ser Phe Glu Glu Leu Asp Leu Glu
     210                 215                 220                
 Gly Glu Gly Pro Leu Gly Glu Ser Arg Leu Asp Pro Gly Thr Glu Pro
 225                 230                 235                 240
 Leu Gly Thr Thr Lys Trp Leu Trp Glu Pro Thr Ala Pro Glu Lys Gly
                 245                 250                 255    
 Lys Glu
        



      <210> 2490
      <211> 57
      <212> PRT
      <213> Homo sapiens


      <400> 2490
 Pro Glu Arg Ala Asp Ser Ser Pro Leu Ser Gln Val Phe Tyr Ser Lys
   1               5                  10                  15    
 Asp Leu Met Glu Lys Val Lys Ser Pro Glu Leu Gln Ala Glu Ala Lys
              20                  25                  30        
 Ser Tyr Phe Glu Lys Ser Lys Glu Gln Leu Thr Pro Leu Ile Lys Lys
          35                  40                  45            
 Ala Gly Thr Glu Leu Val Asn Phe Leu
      50                  55        



      <210> 2491
      <211> 112
      <212> PRT
      <213> Homo sapiens

      <220>
      <221> misc_feature
      <222> (1)...(112)
      <223> Xaa = any amino acid or symbol as shown in the table 8 as set forth in Example 2


      <400> 2491
 Glu Asp Arg Ser Ala Phe Arg Pro Arg Gln Pro His Thr Leu His Pro
   1               5                  10                  15    
 Leu His Ala Arg Ser Leu Ala Pro Arg Ser Pro Thr Pro Pro Ser Pro
              20                  25                  30        
 Pro Ser Pro Asp Thr Gln Leu Gly Leu Ser Gly Pro Thr Ser Gly Pro
          35                  40                  45            
 Glu Ser Ala Pro Thr Ala Pro Gly Asn Pro Ser Trp Arg Ser Ser Arg
      50                  55                  60                
 Trp Gly Ser Ser Ser Pro Cys Ala Ala Ser Ser Thr Xaa Lys Ser Pro
  65                  70                  75                  80
 Tyr Pro Xaa Cys Ser Pro Thr Cys Ala Phe Pro Ser Pro Arg Leu Pro
                  85                  90                  95    
 Phe Cys Arg Ser Ala Tyr Gln Pro Ala Ala Gly Ala Gly Arg Gly Lys
             100                 105                 110        





      <210> 2492
      <211> 935
      <212> PRT
      <213> Homo sapiens


      <400> 2492
 Met Asp Pro Glu Val Thr Leu Leu Leu Gln Cys Pro Gly Gly Gly Leu
   1               5                  10                  15    
 Pro Gln Glu Gln Ile Gln Ala Glu Leu Ser Pro Ala His Asp Arg Arg
              20                  25                  30        
 Pro Leu Pro Gly Gly Asp Glu Ala Ile Thr Ala Ile Trp Glu Thr Arg
          35                  40                  45            
 Leu Lys Ala Gln Pro Trp Leu Phe Asp Ala Pro Lys Phe Arg Leu His
      50                  55                  60                
 Ser Ala Thr Leu Ala Pro Ile Gly Ser Arg Gly Pro Gln Leu Leu Leu
  65                  70                  75                  80
 Arg Leu Gly Leu Thr Ser Tyr Arg Asp Phe Leu Gly Thr Asn Trp Ser
                  85                  90                  95    
 Ser Ser Ala Ala Trp Leu Arg Gln Gln Gly Ala Thr Asp Trp Gly Asp
             100                 105                 110        
 Thr Gln Ala Tyr Leu Ala Asp Pro Leu Gly Val Gly Ala Ala Leu Ala
         115                 120                 125            
 Thr Ala Asp Asp Phe Leu Val Phe Leu Arg Arg Ser Arg Gln Val Ala
     130                 135                 140                
 Glu Ala Pro Gly Leu Val Asp Val Pro Gly Gly His Pro Glu Pro Gln
 145                 150                 155                 160
 Ser Cys Glu Lys Leu Glu Asn Thr Gly Gly Lys Ile Gly His Arg Lys
                 165                 170                 175    
 Lys Met Pro Tyr Ser Thr Pro Ala Pro Cys Val Ser Pro Leu Lys Leu
             180                 185                 190        
 Asp Leu Trp Leu Ser Val Arg Glu Arg Thr Pro Asp Ser Gly Ser Leu
         195                 200                 205            
 Thr Leu Leu His Cys Ala Thr Ser Asp Pro Gln Gly Gln Gln Ala Leu
     210                 215                 220                
 Cys Pro Gly Gly Ser Pro Gln His Gln Asp Leu Ala Gly Gln Leu Val
 225                 230                 235                 240
 Val His Glu Leu Phe Ser Ser Val Leu Gln Glu Ile Cys Asp Glu Val
                 245                 250                 255    
 Asn Leu Pro Leu Leu Thr Leu Ser Gln Pro Leu Leu Leu Gly Ile Ala
             260                 265                 270        
 Arg Asn Glu Thr Ser Ala Gly Arg Ala Ser Ala Glu Phe Tyr Val Gln
         275                 280                 285            
 Cys Ser Leu Thr Ser Glu Gln Val Arg Lys His Tyr Leu Ser Gly Gly
     290                 295                 300                
 Pro Glu Ala His Glu Ser Thr Gly Ile Phe Phe Val Glu Thr Gln Asn
 305                 310                 315                 320
 Val Arg Arg Leu Pro Glu Thr Glu Met Trp Ala Glu Leu Cys Pro Ser
                 325                 330                 335    
 Ala Lys Gly Ala Ile Ile Leu Tyr Asn Arg Val Asp Val Val Leu Ala
             340                 345                 350        
 Ser Thr Pro Met Arg Ile Cys Pro Pro Ala Ala Met Pro Pro Leu Leu
         355                 360                 365            
 Pro Leu Arg Leu Cys Arg Leu Trp Pro Arg Asn Pro Pro Ser Arg Leu
     370                 375                 380                
 Leu Gly Ala Ala Ala Gly Gln Arg Ser Arg Pro Ser Thr Tyr Tyr Glu
 385                 390                 395                 400
 Leu Leu Gly Val His Pro Gly Ala Ser Thr Glu Glu Val Lys Arg Ala
                 405                 410                 415    
 Phe Phe Ser Lys Ser Lys Glu Leu His Pro Asp Arg Asp Pro Gly Asn
             420                 425                 430        
 Pro Ser Leu His Ser Arg Phe Val Glu Leu Ser Glu Ala Tyr Arg Val
         435                 440                 445            
 Leu Ser Arg Glu Gln Ser Arg Arg Ser Tyr Asp Asp Gln Leu Arg Ser
     450                 455                 460                
 Gly Ser Pro Pro Lys Ser Pro Arg Thr Thr Val His Asp Lys Ser Ala
 465                 470                 475                 480
 His Gln Thr His Ser Ser Ser Trp Thr Pro Pro Asn Ala Gln Tyr Trp
                 485                 490                 495    
 Ser Gln Phe His Ser Val Arg Pro Gln Gly Pro Gln Leu Arg Gln Gln
             500                 505                 510        
 Gln His Lys Gln Asn Lys Gln Val Leu Gly Tyr Cys Leu Leu Leu Met
         515                 520                 525            
 Leu Ala Gly Met Gly Leu His Tyr Ile Ala Phe Arg Lys Val Lys Gln
     530                 535                 540                
 Met His Leu Asn Phe Met Asp Glu Lys Asp Arg Ile Ile Thr Ala Phe
 545                 550                 555                 560
 Tyr Asn Glu Ala Arg Ala Arg Ala Arg Ser Val Pro Ala Leu Phe Cys
                 565                 570                 575    
 Ser Leu Leu Pro Val Gln Glu Pro His Phe Gly Ile Pro Ile Pro Thr
             580                 585                 590        
 Thr Gln Ala Pro Val Ser Gln Pro Asp Ala Pro Gly His Gln Arg Lys
         595                 600                 605            
 Val Val Ser Trp Ile Asp Val Tyr Thr Arg Ala Thr Cys Gln Pro Arg
     610                 615                 620                
 Glu Val Val Val Pro Leu Thr Val Glu Leu Met Gly Thr Val Ala Lys
 625                 630                 635                 640
 Gln Leu Val Pro Ser Cys Val Thr Val Gln Arg Cys Gly Gly Cys Cys
                 645                 650                 655    
 Pro Asp Asp Gly Leu Glu Cys Val Pro Thr Gly Gln His Gln Val Arg
             660                 665                 670        
 Met Gln Val Leu Gly Thr Trp Gly Asn Gly Gln Gly Met Gln Ile Leu
         675                 680                 685            
 Met Ile Arg Tyr Pro Ser Ser Gln Leu Gly Glu Met Ser Leu Glu Glu
     690                 695                 700                
 His Ser Gln Cys Glu Cys Arg Pro Lys Lys Lys Asp Ser Ala Val Lys
 705                 710                 715                 720
 Pro Asp Ser Pro Arg Pro Leu Cys Pro Arg Cys Thr Gln His His Gln
                 725                 730                 735    
 Arg Pro Asp Pro Arg Thr Cys Arg Cys Arg Cys Arg Arg Arg Ser Phe
             740                 745                 750        
 Leu Arg Cys Gln Gly Arg Gly Leu Glu Leu Asn Pro Asp Thr Cys Arg
         755                 760                 765            
 Phe Ser Cys Leu Ser Thr Ala Gly Ser Leu Leu Gln Leu Thr Asp Val
     770                 775                 780                
 Trp Trp Leu Leu Gly Arg Leu Lys Ile Ser Leu Val Gly Glu Gln Ala
 785                 790                 795                 800
 Gln Pro Asp His Ser Ser His Glu Ser Gln Pro Arg Cys Thr Gly Arg
                 805                 810                 815    
 Val Leu Ser Ile Cys Leu Ser Ala Val Ala Thr Ala Thr Gly Ala Glu
             820                 825                 830        
 Gly Lys Arg Lys Leu Gln Ile Gly Val Lys Lys Arg Val Asp His Cys
         835                 840                 845            
 Pro Ile Lys Ser Arg Lys Gly Asp Val Leu His Met His Tyr Thr Gly
     850                 855                 860                
 Lys Leu Glu Asp Gly Thr Glu Phe Asp Ser Ser Leu Pro Gln Asn Gln
 865                 870                 875                 880
 Pro Phe Val Phe Ser Leu Gly Thr Gly Gln Val Ile Lys Gly Trp Asp
                 885                 890                 895    
 Gln Gly Leu Leu Gly Met Cys Glu Gly Glu Lys Arg Lys Leu Val Ile
             900                 905                 910        
 Pro Ser Glu Leu Gly Lys Arg Pro Leu Leu Arg Val Gln Ser Glu Phe
         915                 920                 925            
 Gly Val Cys Asp Trp Glu Gly
     930                 935



      <210> 2493
      <211> 64
      <212> PRT
      <213> Homo sapiens

      <220>
      <221> misc_feature
      <222> (1)...(64)
      <223> Xaa = any amino acid or symbol as shown in the table 8 as set forth in Example 2


      <400> 2493
 Lys Lys Thr Met Phe Arg Gln Lys Leu Phe Tyr Lys Arg Lys Gln Leu
   1               5                  10                  15    
 Gln Lys Gly Pro Arg Pro Xaa Gly Ser Ala Lys Lys Lys Leu Cys Phe
              20                  25                  30        
 Gly Lys Ser Tyr Phe Ile Arg Gly Ser Ser Phe Arg Lys Gly Gln Gly
          35                  40                  45            
 His Glu Glu Arg Gly Leu Lys Tyr Lys Lys Lys Thr Gly Glu Gly Val
      50                  55                  60                





      <210> 2494
      <211> 88
      <212> PRT
      <213> Homo sapiens

      <220>
      <221> misc_feature
      <222> (1)...(88)
      <223> Xaa = any amino acid or symbol as shown in the table 8 as set forth in Example 2


      <400> 2494
 Met Leu Leu Thr Leu Ala Pro Ser Asp Leu Trp Met Val Ile Thr Cys
   1               5                  10                  15    
 Pro His Leu Val Tyr His Gln Arg Thr Gln Gln His Val Cys His Pro
              20                  25                  30        
 Arg Ser Ile Glu Gln Thr Leu Thr Arg Gln Pro Thr Ser Trp Xaa Xaa
          35                  40                  45            
 Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Pro Leu Leu Cys
      50                  55                  60                
 Pro Asp Pro Thr Val Asn Arg Ser Gln Ser His Leu Glu Glu His Ala
  65                  70                  75                  80
 Thr Thr Arg Asn Lys Phe Ile Ser
                  85            



      <210> 2495
      <211> 205
      <212> PRT
      <213> Homo sapiens


      <400> 2495
 Arg Trp Asn Ser Met Asp Ala Cys Asn Arg Tyr Ser Lys Leu Asn Cys
   1               5                  10                  15    
 Leu Val Ala Pro Thr Leu Phe Leu Glu Phe His Gly Ser Gln Gln Ala
              20                  25                  30        
 Leu Glu Glu Gln Leu Gln Arg Thr Glu Glu Ile Val Gln Gln Asn Gly
          35                  40                  45            
 Ala Ser Asp Phe Ser Trp Ala Lys Glu Ala Glu Glu Arg Ser Arg Leu
      50                  55                  60                
 Trp Thr Ala Arg His Asn Ala Trp Tyr Ala Ala Leu Ala Thr Arg Pro
  65                  70                  75                  80
 Gly Cys Lys Gly Tyr Ser Thr Asp Val Cys Val Pro Ile Ser Arg Leu
                  85                  90                  95    
 Pro Glu Ile Val Val Gln Thr Lys Glu Asp Leu Asn Ala Ser Gly Leu
             100                 105                 110        
 Thr Gly Ser Ile Val Gly His Val Gly Asp Gly Asn Phe His Cys Ile
         115                 120                 125            
 Leu Leu Val Asn Pro Asp Asp Ala Glu Glu Leu Gly Arg Val Lys Ala
     130                 135                 140                
 Phe Ala Glu Gln Leu Gly Arg Arg Ala Leu Ala Leu His Gly Thr Cys
 145                 150                 155                 160
 Thr Gly Glu His Gly Ile Gly Met Gly Lys Arg Gln Leu Leu Gln Glu
                 165                 170                 175    
 Glu Val Gly Ala Val Gly Val Glu Thr Met Arg Gln Leu Lys Ala Val
             180                 185                 190        
 Leu Asp Pro Gln Gly Leu Met Asn Pro Gly Lys Val Leu
         195                 200                 205



      <210> 2496
      <211> 123
      <212> PRT
      <213> Homo sapiens


      <400> 2496
 Ser Pro Phe Trp Thr Glu Lys Arg Arg Met Glu Lys Pro Leu Phe Pro
   1               5                  10                  15    
 Leu Val Pro Leu His Trp Phe Gly Phe Gly Tyr Thr Ala Leu Val Val
              20                  25                  30        
 Ser Gly Gly Ile Val Gly Tyr Val Lys Thr Gly Ser Val Pro Ser Leu
          35                  40                  45            
 Ala Ala Gly Leu Leu Phe Gly Ser Leu Ala Gly Leu Gly Ala Tyr Gln
      50                  55                  60                
 Leu Tyr Gln Asp Pro Arg Asn Val Trp Gly Phe Leu Ala Ala Thr Ser
  65                  70                  75                  80
 Val Thr Phe Val Gly Val Met Gly Met Arg Ser Tyr Tyr Tyr Gly Lys
                  85                  90                  95    
 Phe Met Pro Val Gly Leu Ile Ala Gly Ala Ser Leu Leu Met Ala Ala
             100                 105                 110        
 Lys Val Gly Val Arg Met Leu Met Thr Ser Asp
         115                 120            



      <210> 2497
      <211> 135
      <212> PRT
      <213> Homo sapiens


      <400> 2497
 Leu Pro Phe Leu Ser Phe Phe Leu Ser Phe Phe Leu Phe Phe Leu Arg
   1               5                  10                  15    
 Trp Ser Phe Ala Leu Ile Ala Gln Ala Gly Val Gln Trp Cys Asn Phe
              20                  25                  30        
 Gly Ser Pro Gln Pro Pro Pro Pro Gly Phe Lys Arg Phe Ser Cys Leu
          35                  40                  45            
 Ser Leu Leu Ser Ser Trp Asp Tyr Arg His Thr Pro Pro Cys Leu Ala
      50                  55                  60                
 Asn Ser Val Phe Leu Val Asp Thr Gly Phe Leu His Val Gly Gln Ala
  65                  70                  75                  80
 Gly Leu Glu Leu Pro Thr Ser Gly Asp Pro Pro Thr Ser Ala Ser Gln
                  85                  90                  95    
 Ser Ala Gly Ile Thr Ser Val Ser His Cys Ala Gln Pro Val Thr Ala
             100                 105                 110        
 Ile Ser Lys Glu Glu Arg Glu Gln Ala Glu Gly Pro Asp Ser Gln Gly
         115                 120                 125            
 Thr Gly Ser Ser Ala Gly Gln
     130                 135



      <210> 2498
      <211> 164
      <212> PRT
      <213> Homo sapiens


      <400> 2498
 Leu Asn Tyr Ser Arg Val Pro Ser Thr Thr His Ala Asp Cys Gly Asn
   1               5                  10                  15    
 Tyr Lys Arg Asn Leu Ala Leu Arg Gly Ser Leu Pro Arg Pro Thr Arg
              20                  25                  30        
 Asn Thr Pro Trp Lys Leu Glu Ser Ala Thr Met Ala Gln Gly Val Leu
          35                  40                  45            
 Trp Ile Leu Leu Gly Leu Leu Leu Gly Gln Thr Gln Gly Gln Asp Ala
      50                  55                  60                
 Arg Pro Ser Thr Pro Leu Pro Leu Gly Ser Gly Ala Leu Ser Gly Pro
  65                  70                  75                  80
 Pro Glu Ala Ala Ala Val Pro Leu Gly Phe Leu Tyr Val His His Thr
                  85                  90                  95    
 Tyr Val Pro Ala Pro Pro Ala Arg Thr Ser Arg Ala Ala Gln Pro Thr
             100                 105                 110        
 Cys Ala Pro Cys Ser Ala Pro Pro Gly His Ala Arg Leu Gly Arg His
         115                 120                 125            
 Arg Leu Gln Phe Val Val Gly Ser Asp Gly Tyr Val Tyr Glu Gly Arg
     130                 135                 140                
 Gly Trp His Trp Trp Ala Pro Thr Arg Ser Ala Thr Thr Pro Gly Ala
 145                 150                 155                 160
 Ser Ala Trp Pro
                



      <210> 2499
      <211> 48
      <212> PRT
      <213> Homo sapiens


      <400> 2499
 Met Ser Ala Leu Trp Leu Val Tyr Val Ser Cys Gly Cys Ser Cys Ala
   1               5                  10                  15    
 Leu Cys Val Leu Val His Ala Gln Thr Cys Thr Ser Phe Ser Ile Leu
              20                  25                  30        
 Val His Ala Gln Ala His Val Leu Ser Cys Asp His Ile His Thr Ser
          35                  40                  45            





      <210> 2500
      <211> 189
      <212> PRT
      <213> Homo sapiens


      <400> 2500
 Met Gly Ser Lys Ala Lys Lys Arg Val Leu Leu Pro Thr Arg Pro Ala
   1               5                  10                  15    
 Pro Pro Thr Val Glu Gln Ile Leu Glu Asp Val Arg Gly Ala Pro Ala
              20                  25                  30        
 Glu Lys Thr Val Phe Thr Ile Leu Ala Pro Glu Asp Pro Pro Val Pro
          35                  40                  45            
 Phe Arg Met Met Glu Asp Ala Glu Ala Pro Gly Glu Gln Leu Tyr Gln
      50                  55                  60                
 Gln Ser Arg Ala Tyr Val Ala Ala Asn Gln Arg Leu Gln Gln Ala Gly
  65                  70                  75                  80
 Asn Val Leu Ser Gln Arg Ser Glu Leu Leu Gln Arg Ala Gly Val Asp
                  85                  90                  95    
 Leu Gly Arg Glu Val Glu Leu Met Asn Ile Glu Gln Lys Lys Lys Thr
             100                 105                 110        
 Asp Gly Asn Glu Lys Lys Leu Glu Lys Val Lys Ala Tyr Arg Glu Lys
         115                 120                 125            
 Ile Glu Lys Glu Leu Glu Thr Val Cys Asn Asp Val Leu Ser Leu Leu
     130                 135                 140                
 Asp Lys Phe Leu Ile Lys Asn Cys Asn Asp Phe Gln Tyr Glu Ser Lys
 145                 150                 155                 160
 Val Phe Tyr Met Lys Met Lys Gly Asp Tyr Tyr Arg Tyr Leu Ala Lys
                 165                 170                 175    
 Met Pro Cys Ala Gly Gly Phe His Ala Ala Asp Met Lys
             180                 185                



      <210> 2501
      <211> 124
      <212> PRT
      <213> Homo sapiens


      <400> 2501
 Glu Ala Ala Ser Ala His Gln Ser Cys Arg Pro Gly Pro Ala Ala Glu
   1               5                  10                  15    
 Thr Thr Pro Ala Ala Arg Arg Pro Gly Arg Gly Glu Thr Arg Lys Arg
              20                  25                  30        
 Met Ser Glu Leu Glu Lys Ala Met Val Ala Leu Ile Asp Val Phe His
          35                  40                  45            
 Gln Tyr Ser Gly Arg Glu Gly Asp Lys His Lys Leu Lys Lys Ser Glu
      50                  55                  60                
 Leu Lys Glu Leu Ile Asn Asn Glu Leu Ser His Phe Leu Glu Glu Ile
  65                  70                  75                  80
 Lys Glu Gln Glu Val Val Asp Lys Val Met Glu Thr Leu Asp Asn Asp
                  85                  90                  95    
 Gly Asp Gly Glu Cys Asp Phe Gln Glu Phe Met Ala Phe Val Ala Met
             100                 105                 110        
 Val Thr Thr Ala Cys His Glu Phe Phe Glu His Glu
         115                 120                



      <210> 2502
      <211> 56
      <212> PRT
      <213> Homo sapiens


      <400> 2502
 Met Leu Leu Ala Leu Pro Leu Ala Ala Pro Ser Cys Pro Met Leu Cys
   1               5                  10                  15    
 Thr Cys Tyr Ser Ser Pro Pro Thr Val Ser Cys Gln Ala Asn Asn Phe
              20                  25                  30        
 Ser Ser Val Pro Leu Ser Leu Pro Pro Ser Thr Gln Arg Leu Phe Leu
          35                  40                  45            
 Gln Asn Asn Leu Ile Arg Thr Leu
      50                  55    



      <210> 2503
      <211> 52
      <212> PRT
      <213> Homo sapiens


      <400> 2503
 Met Ile Gln Tyr Ala Val Phe Val Leu Cys Gly Phe Leu Tyr Leu Cys
   1               5                  10                  15    
 Phe Met Leu Phe Phe Phe Ser Ser Val Thr Gln Ala Gly Val Ser Glu
              20                  25                  30        
 Pro Arg Ser Ser His Cys Thr Pro Ala Trp Ala Thr Glu Arg Asp Cys
          35                  40                  45            
 Val Ser Asn Lys
      50        



      <210> 2504
      <211> 307
      <212> PRT
      <213> Homo sapiens

      <220>
      <221> misc_feature
      <222> (1)...(307)
      <223> Xaa = any amino acid or symbol as shown in the table 8 as set forth in Example 2


      <400> 2504
 Glu Asp Leu Ala Gly Leu Asn Met His Trp Leu Arg Lys Val Gln Gly
   1               5                  10                  15    
 Leu Cys Thr Leu Trp Gly Thr Gln Met Ser Ser Arg Thr Leu Tyr Ile
              20                  25                  30        
 Asn Ser Arg Gln Leu Val Ser Leu Gln Trp Gly His Gln Glu Val Pro
          35                  40                  45            
 Ala Lys Phe Asn Phe Ala Ser Asp Val Leu Asp His Trp Ala Asp Met
      50                  55                  60                
 Glu Lys Ala Gly Lys Arg Leu Pro Ser Pro Ala Leu Trp Trp Val Asn
  65                  70                  75                  80
 Gly Lys Gly Lys Glu Leu Met Trp Asn Phe Arg Glu Leu Ser Glu Asn
                  85                  90                  95    
 Ser Gln Gln Ala Ala Asn Val Leu Ser Gly Ala Cys Gly Leu Gln Arg
             100                 105                 110        
 Gly Asp Arg Val Ala Val Met Leu Pro Arg Val Pro Glu Trp Trp Leu
         115                 120                 125            
 Val Ile Leu Gly Cys Ile Arg Ala Gly Leu Ile Phe Met Pro Gly Thr
     130                 135                 140                
 Ile Gln Met Lys Ser Thr Asp Ile Leu Tyr Arg Leu Gln Met Ser Lys
 145                 150                 155                 160
 Ala Lys Ala Ile Val Ala Gly Asp Glu Val Ile Gln Glu Val Asp Thr
                 165                 170                 175    
 Val Ala Ser Glu Cys Pro Ser Leu Arg Ile Lys Leu Leu Val Ser Glu
             180                 185                 190        
 Lys Ser Cys Asp Gly Trp Leu Asn Phe Lys Lys Leu Leu Asn Glu Ala
         195                 200                 205            
 Ser Thr Thr His His Cys Val Glu Thr Gly Ser Gln Glu Ala Ser Ala
     210                 215                 220                
 Ile Tyr Phe Thr Ser Gly Thr Ser Gly Leu Pro Lys Met Ala Glu His
 225                 230                 235                 240
 Ser Tyr Ser Ser Leu Gly Leu Lys Ala Lys Met Asp Gly Trp Thr Leu
                 245                 250                 255    
 Ser Ser Tyr Pro Ile Lys Ser Met Met Gly Ala Pro Ile Val Tyr Arg
             260                 265                 270        
 Met Leu Leu Gln Gln Asp Leu Ser Arg Xaa Trp Gly Phe Glu Asp Trp
         275                 280                 285            
 Xaa Glu Ser Leu Ala Pro Ser Pro Xaa Leu Pro His Ile His Ser Cys
     290                 295                 300                
 Leu Ser Ile
 305        



      <210> 2505
      <211> 517
      <212> PRT
      <213> Homo sapiens


      <400> 2505
 Met Pro Tyr Ser Leu Asn Leu Ala Ile Arg Asp Thr Phe Val Asn Ala
   1               5                  10                  15    
 Ser Arg Thr Leu Tyr Ser Ser Ser Pro Arg Val Leu Ser Asn Asn Ser
              20                  25                  30        
 Asp Ala Asn Leu Glu Leu Ile Asn Thr Trp Val Ala Lys Asn Thr Asn
          35                  40                  45            
 Asn Lys Ile Ser Arg Leu Leu Asp Ser Leu Pro Ser Asp Thr Arg Leu
      50                  55                  60                
 Val Leu Leu Asn Ala Ile Tyr Leu Ser Ala Lys Trp Lys Thr Thr Phe
  65                  70                  75                  80
 Asp Pro Lys Lys Thr Arg Met Glu Pro Phe His Phe Lys Asn Ser Val
                  85                  90                  95    
 Ile Lys Val Pro Met Met Asn Ser Lys Lys Tyr Pro Val Ala His Phe
             100                 105                 110        
 Ile Asp Gln Thr Leu Lys Ala Lys Leu Ser Arg Gly Asp Ser Leu Lys
         115                 120                 125            
 Glu Pro Thr Ser Ile Ala Glu Ser Ser Arg His Pro Ser Tyr Arg Ser
     130                 135                 140                
 Glu Pro Ser Leu Glu Pro Glu Ser Phe Arg Ser Pro Thr Phe Gly Lys
 145                 150                 155                 160
 Ser Phe His Phe Asp Pro Leu Ser Ser Gly Ser Arg Ser Ser Ser Leu
                 165                 170                 175    
 Lys Ser Ala Gln Gly Thr Gly Phe Glu Leu Gly Gln Leu Gln Ser Ile
             180                 185                 190        
 Arg Ser Glu Gly Thr Thr Ser Thr Ser Tyr Lys Ser Leu Ala Asn Gln
         195                 200                 205            
 Thr Arg Asn Gly Ser Leu Ser Tyr Asp Ser Leu Leu Thr Pro Ser Asp
     210                 215                 220                
 Ser Pro Asp Phe Glu Ser Val Gln Ala Gly Pro Glu Pro Asp Pro Pro
 225                 230                 235                 240
 Leu Gly Tyr Thr Ser Pro Phe Leu Ser Ala Arg Leu Ala Gln Gln Arg
                 245                 250                 255    
 Glu Ala Glu Arg His Pro Arg Leu Val Pro Thr Gly Pro Thr His Arg
             260                 265                 270        
 Glu Pro Ser Pro Val Arg Tyr Asp Asn Leu Ser Arg His Ile Val Ala
         275                 280                 285            
 Ser Leu Gln Glu Arg Glu Lys Leu Leu Arg Gln Ser Pro Pro Leu Pro
     290                 295                 300                
 Gly Arg Glu Glu Glu Pro Gly Leu Gly Asp Ser Gly Ile Gln Ser Thr
 305                 310                 315                 320
 Pro Gly Ser Gly His Ala Pro Arg Thr Ser Ser Ser Ser Asp Asp Ser
                 325                 330                 335    
 Lys Arg Ser Pro Leu Gly Lys Thr Pro Leu Gly Arg Pro Ala Val Pro
             340                 345                 350        
 Arg Phe Gly Lys Pro Asp Gly Leu Arg Gly Arg Gly Val Gly Phe Pro
         355                 360                 365            
 Glu Pro Gly Pro Thr Ala Pro Tyr Leu Gly Arg Ser Met Ser Tyr Ser
     370                 375                 380                
 Ser Gln Ile Ala Gln Pro Gly Val Ser Glu Thr Glu Glu Val Asp Leu
 385                 390                 395                 400
 Arg Pro Leu Leu Thr Pro Lys Asp Glu Val Gln Leu Lys Thr Thr Tyr
                 405                 410                 415    
 Ser Lys Ser Asn Gly Gln Pro Lys Ser Leu Gly Ser Ala Ser Pro Gly
             420                 425                 430        
 Pro Gly Gln Pro Pro Leu Ser Ser Pro Thr Arg Gly Gly Val Lys Lys
         435                 440                 445            
 Val Ser Gly Val Gly Gly Thr Thr Tyr Glu Ile Ser Glu Phe Asp His
     450                 455                 460                
 His Cys Pro Trp Val Asn Asn Cys Ile Gly Arg Arg Asn Tyr Arg Tyr
 465                 470                 475                 480
 Phe Phe Leu Phe Leu Leu Ser Leu Thr Ala His Ile Met Gly Val Phe
                 485                 490                 495    
 Gly Phe Gly Leu Leu Tyr Val Leu Tyr His Ile Glu Glu Leu Ser Gly
             500                 505                 510        
 Val Arg Thr Ala Val
         515        



      <210> 2506
      <211> 104
      <212> PRT
      <213> Homo sapiens


      <400> 2506
 Gln Asn Leu Cys Leu Gly Lys Gly Leu Met Ala Leu Ser Leu Gly Trp
   1               5                  10                  15    
 Lys Ala His Arg Asn His Cys Gly Leu Leu Leu Gln Ala Leu Arg Ser
              20                  25                  30        
 Ser Gly Leu Leu Leu Phe Pro Cys Gly Gln Cys Pro Trp Arg Gly Ala
          35                  40                  45            
 Gly Ser Phe Leu Asp Pro Glu Ile Lys Ala Phe Leu Glu Glu Asn Thr
      50                  55                  60                
 Glu Val Thr Ser Ser Gly Ser Leu Thr Pro Glu Ile Gln Leu Arg Leu
  65                  70                  75                  80
 Leu Thr Pro Arg Cys Lys Phe Trp Trp Glu Arg Ala Asp Leu Trp Pro
                  85                  90                  95    
 His Ser Asp Pro Tyr Trp Ala Ile
             100                



      <210> 2507
      <211> 336
      <212> PRT
      <213> Homo sapiens


      <400> 2507
 Lys Ser Val Glu Ile Thr Lys Gln Asp Thr Lys Val Glu Leu Glu Thr
   1               5                  10                  15    
 Tyr Lys Gln Thr Arg Gln Gly Leu Asp Glu Met Tyr Ser Asp Val Trp
              20                  25                  30        
 Lys Gln Leu Lys Glu Glu Lys Lys Val Arg Leu Glu Leu Glu Lys Glu
          35                  40                  45            
 Leu Glu Leu Gln Ile Gly Met Lys Thr Glu Met Glu Ile Ala Met Lys
      50                  55                  60                
 Leu Leu Glu Lys Asp Thr His Glu Lys Gln Asp Thr Leu Val Ala Leu
  65                  70                  75                  80
 Arg Gln Gln Leu Glu Glu Val Lys Ala Ile Asn Leu Gln Met Phe His
                  85                  90                  95    
 Lys Ala Gln Asn Ala Glu Ser Ser Leu Gln Gln Lys Asn Glu Ala Ile
             100                 105                 110        
 Thr Ser Phe Glu Gly Lys Thr Asn Gln Val Met Ser Ser Met Lys Gln
         115                 120                 125            
 Met Glu Glu Arg Leu Gln His Ser Glu Arg Ala Arg Gln Gly Ala Glu
     130                 135                 140                
 Glu Arg Ser His Lys Leu Gln Gln Glu Leu Gly Gly Arg Ile Gly Ala
 145                 150                 155                 160
 Leu Gln Leu Gln Leu Ser Gln Leu His Glu Gln Cys Ser Ser Leu Glu
                 165                 170                 175    
 Lys Glu Leu Lys Ser Glu Lys Glu Gln Arg Gln Ala Leu Gln Arg Glu
             180                 185                 190        
 Leu Gln His Glu Lys Asp Thr Ser Ser Leu Leu Arg Met Glu Leu Gln
         195                 200                 205            
 Gln Val Glu Gly Leu Lys Lys Glu Leu Arg Glu Leu Gln Asp Glu Lys
     210                 215                 220                
 Ala Glu Leu Gln Lys Ile Cys Glu Glu Gln Glu Gln Ala Leu Gln Glu
 225                 230                 235                 240
 Met Gly Leu His Leu Ser Gln Ser Lys Leu Lys Met Glu Asp Ile Lys
                 245                 250                 255    
 Glu Val Asn Gln Ala Leu Lys Gly His Ala Trp Leu Lys Asp Asp Glu
             260                 265                 270        
 Ala Thr His Cys Arg Gln Cys Glu Lys Glu Phe Ser Ile Ser Arg Arg
         275                 280                 285            
 Lys His His Cys Arg Asn Cys Gly His Ile Phe Cys Asn Thr Cys Ser
     290                 295                 300                
 Ser Asn Glu Leu Ala Leu Pro Ser Tyr Pro Lys Pro Val Arg Val Cys
 305                 310                 315                 320
 Asp Ser Cys His Thr Leu Leu Leu Gln Arg Cys Ser Ser Thr Ala Ser
                 325                 330                 335    





      <210> 2508
      <211> 449
      <212> PRT
      <213> Homo sapiens


      <400> 2508
 Met Lys Arg Leu Leu Glu Arg Arg Asn Trp Thr Pro Gln Ala Met Leu
   1               5                  10                  15    
 Tyr Leu Lys Gly Ala Gln Gly Arg Arg Phe Ile Ser Asp Gln Ser Arg
              20                  25                  30        
 Arg Lys Asp Leu Ser Asp Arg Pro Leu Pro Glu Ser Val Ser Ser Pro
          35                  40                  45            
 Glu Arg Arg Gly Ser Glu Ala Pro Ser Asp Thr Val Arg Pro Arg Ala
      50                  55                  60                
 Ala Arg Val Gly Ser Ser Ser Ser Trp Met Pro Ser Ala Gly Ala Gly
  65                  70                  75                  80
 Ser Ser Arg Val Gln Pro Arg Ala Asn Gly Gly Lys Gly Gly Pro Gly
                  85                  90                  95    
 Trp Arg Cys Gly Ser Pro Ser Leu Ile Gly Leu Arg Leu Phe Ser Gln
             100                 105                 110        
 Pro Ser Gly Cys Gln Glu Arg Arg Ser Pro Asn Pro Gln Leu Leu Thr
         115                 120                 125            
 Ile Pro Glu Ala Ala Thr Ile Leu Leu Ala Ser Leu Gln Lys Ser Pro
     130                 135                 140                
 Glu Glu Gln Phe Ser Ser Lys Ala Ile Trp Glu Gly Ala Val Glu Val
 145                 150                 155                 160
 Gln Arg Lys Ala Ser Glu Ser Lys Gln Phe Glu Lys Cys Leu His Lys
                 165                 170                 175    
 Glu Glu Gln Pro Lys Ala Val Ser Glu Pro Glu Trp Arg Glu Glu Gly
             180                 185                 190        
 Ile Arg Ala Cys Glu Gly Val Tyr Gly Glu Arg Leu Val Thr Gln Lys
         195                 200                 205            
 Lys Ile Asp Pro Ile Cys Ser Lys Leu Lys Val Ile Leu His Pro Glu
     210                 215                 220                
 Phe Leu Ser Ser Thr Ser Pro Leu Leu Pro Met Asp Tyr Glu Glu Phe
 225                 230                 235                 240
 Val Arg Gly Cys His Leu Gly Val Phe Pro Ser Tyr Tyr Glu Pro Trp
                 245                 250                 255    
 Gly Tyr Thr Pro Gly Gly Leu Gly Pro Phe Pro Pro Leu Ser Ala Tyr
             260                 265                 270        
 Lys Asp Ile Gly Ala Gly Leu Lys Pro Ser Phe Gly Leu Phe Pro Leu
         275                 280                 285            
 Ala Ala Glu Cys Thr Val Met Gly Ile Pro Ser Val Thr Thr Asn Leu
     290                 295                 300                
 Ser Gly Phe Gly Cys Phe Met Gln Glu His Val Ala Asp Pro Thr Ala
 305                 310                 315                 320
 Tyr Gly Ile Tyr Ile Val Asp Arg Arg Phe Arg Ser Pro Asp Asp Ser
                 325                 330                 335    
 Cys Asn Gln Leu Thr Lys Phe Leu Tyr Gly Phe Cys Lys Gln Ser Arg
             340                 345                 350        
 Arg Gln Arg Ile Ile Gln Arg Asn Arg Thr Glu Arg Leu Ser Asp Leu
         355                 360                 365            
 Leu Asp Trp Arg Tyr Leu Gly Arg Thr Glu Gly Phe Lys Tyr Pro Arg
     370                 375                 380                
 Pro Ser Ser Val Pro Pro Ser Pro Ser Gly Ser Gln Ala Ser Ser Pro
 385                 390                 395                 400
 Gln Ser Ser Asp Val Glu Asp Glu Val Glu Asp Glu Arg Tyr Asp Glu
                 405                 410                 415    
 Glu Glu Glu Ala Glu Arg Asp Arg Leu Asn Ile Lys Ser Pro Phe Ser
             420                 425                 430        
 Leu Ser His Val Pro His Gly Lys Lys Lys Leu His Gly Glu Tyr Lys
         435                 440                 445            
 Asn
    



      <210> 2509
      <211> 110
      <212> PRT
      <213> Homo sapiens


      <400> 2509
 Ile Leu Asp Arg Pro Gln Gly Arg Ala Thr Pro Ala Gln Gly Ser Gly
   1               5                  10                  15    
 Leu Leu Val Gly Gly Arg Ser Pro Thr Gln Leu Gln Val Gly Glu Gly
              20                  25                  30        
 Leu Leu Val Lys Pro Gly Gly His Arg Leu Asp Ser Arg Gly His Val
          35                  40                  45            
 Leu Arg Pro Arg Trp Ala Asp His Leu Arg Ser Gly Val Gln Asp Gln
      50                  55                  60                
 His Gly Lys Arg Gly Glu Thr Pro Ser Leu Leu Lys Ile Gln Lys Ile
  65                  70                  75                  80
 Ser Arg Ala Trp Trp His Thr Pro Val Ile Pro Ala Thr Leu Asp Ala
                  85                  90                  95    
 Glu Ala Arg Glu Ser Leu Glu Pro Arg Arg Gln Arg Leu Gln
             100                 105                 110



      <210> 2510
      <211> 214
      <212> PRT
      <213> Homo sapiens


      <400> 2510
 Ala Ile Leu Glu Ala Ala Phe Gln Phe Leu Ser Pro Leu Gln Gln Asn
   1               5                  10                  15    
 Leu Phe Lys Phe Cys Leu Ser Leu Arg Ser Tyr Ser Ala Thr Ile Gln
              20                  25                  30        
 Ala Phe Gln Gln Ile Ala Ala Asp Glu Pro Pro Pro Glu Gly Cys Asn
          35                  40                  45            
 Ser Phe Phe Ser Val His Gly Lys Lys Thr Cys Glu Ser Asp Thr Leu
      50                  55                  60                
 Glu Ala Leu Leu Leu Thr Ala Ser Glu Arg Pro Lys Pro Leu Leu Phe
  65                  70                  75                  80
 Lys Gly Asp His Arg Tyr Pro Ser Ser Asn Pro Glu Ser Pro Val Val
                  85                  90                  95    
 Ile Phe Tyr Ser Glu Ile Gly Ser Glu Glu Phe Ser Asn Phe His Arg
             100                 105                 110        
 Gln Leu Ile Ser Lys Ser Asn Ala Gly Lys Ile Asn Tyr Val Phe Arg
         115                 120                 125            
 His Tyr Ile Phe Asn Pro Arg Lys Glu Pro Val Tyr Leu Ser Gly Tyr
     130                 135                 140                
 Gly Val Glu Leu Ala Ile Lys Ser Thr Glu Tyr Lys Ala Lys Asp Asp
 145                 150                 155                 160
 Thr Gln Val Lys Gly Thr Glu Val Asn Thr Thr Val Ile Gly Glu Asn
                 165                 170                 175    
 Asp Pro Ile Asp Glu Val Gln Gly Phe Leu Phe Gly Lys Leu Arg Asp
             180                 185                 190        
 Leu His Pro Asp Leu Glu Gly Gln Leu Lys Glu Leu Arg Lys His Leu
         195                 200                 205            
 Val Glu Ser Thr Cys Ile
     210                



      <210> 2511
      <211> 256
      <212> PRT
      <213> Homo sapiens

      <220>
      <221> misc_feature
      <222> (1)...(256)
      <223> Xaa = any amino acid or symbol as shown in the table 8 as set forth in Example 2


      <400> 2511
 Arg Val Gln Gly Cys Gly Leu Leu Gly Glu Pro Ser Glu Leu Asp Gln
   1               5                  10                  15    
 Gly Lys Gly Leu Gly Val Gly Asp Asp Arg Gly Leu Trp Leu Glu Gly
              20                  25                  30        
 Ala Gly Met Gln Glu Met Val Phe Gly Ser Gly Ile Gln Gly Leu Ala
          35                  40                  45            
 Ser Pro Glu Ser Phe Phe Pro Pro Pro Gly Arg Thr Trp Thr Gln Gly
      50                  55                  60                
 Glu Glu Val Cys Pro Glu Pro Gly Ser Arg Gly Pro Gly Pro Arg Pro
  65                  70                  75                  80
 Arg Ala Gly Pro Xaa Cys Ser Cys Pro Pro Thr Ala Leu Gly Gly Ser
                  85                  90                  95    
 Pro Ser Gly Ala Cys Pro Cys Phe Gly Ala Pro Xaa Gln Arg Arg Ser
             100                 105                 110        
 Cys Ala Cys Phe Asp Arg Arg Ala Asp Trp Arg Pro Trp Leu Pro Glu
         115                 120                 125            
 Gln Ser Leu Arg Pro Gly Ser Leu Pro Pro Gly Arg Leu Gly Ser Ser
     130                 135                 140                
 Gln Ser Gly Gly Phe Trp Gly Cys Gln Gln Ala Leu Arg Val Pro Cys
 145                 150                 155                 160
 Arg Gly Ala Leu Ala Ala Cys Leu Leu Gln Ser Glu Leu Val Asn Tyr
                 165                 170                 175    
 Glu Arg Val Arg Glu Tyr Cys Leu Lys Val Leu Asp Lys His Gln Gly
             180                 185                 190        
 Asn Phe Lys Ala Thr Tyr Arg Ala Gly Ile Ala Phe Tyr His Leu Gly
         195                 200                 205            
 Asp Tyr Ala Arg Ala Leu Arg Tyr Leu Gln Glu Ala Arg Ser Arg Glu
     210                 215                 220                
 Pro Thr Gly Glu Trp Arg Ser Ala Pro His Glu Arg Ala Gly Pro Thr
 225                 230                 235                 240
 Ala Ala Lys Gly Ala Ala Ala Glu Gly Thr Arg Pro Met Ile Arg Ala
                 245                 250                 255    





      <210> 2512
      <211> 127
      <212> PRT
      <213> Homo sapiens


      <400> 2512
 Met Leu Trp Glu Leu Val Leu Leu Gly Glu Pro Leu Val Val Met Ala
   1               5                  10                  15    
 Pro Ser Pro Ser Glu Ser Ser Glu Thr Val Leu Ala Leu Val Asn Cys
              20                  25                  30        
 Ile Ser Pro Leu Lys Tyr Phe Ser Asp Phe Arg Pro Tyr Phe Thr Ile
          35                  40                  45            
 His Asp Ser Glu Phe Lys Glu Tyr Thr Thr Arg Thr Gln Ala Pro Pro
      50                  55                  60                
 Ser Val Ile Leu Gly Val Thr Asn Pro Phe Phe Ala Lys Thr Leu Gln
  65                  70                  75                  80
 His Trp Pro His Ile Ile Arg Ile Gly Asp Leu Lys Pro Thr Gly Glu
                  85                  90                  95    
 Ile Pro Lys Gln Val Lys Val Lys Lys Leu Lys Asn Leu Lys Thr Leu
             100                 105                 110        
 Asp Ser Lys Pro Gly Val Tyr Thr Ser Tyr Lys Pro Tyr Ser Asn
         115                 120                 125        



      <210> 2513
      <211> 254
      <212> PRT
      <213> Homo sapiens

      <220>
      <221> misc_feature
      <222> (1)...(254)
      <223> Xaa = any amino acid or symbol as shown in the table 8 as set forth in Example 2


      <400> 2513
 Asn Gln Pro Gly Trp His Gly Gly Gly Pro Ser Ala Gly Arg Ala Ala
   1               5                  10                  15    
 Lys Lys Cys Pro Gly Glu Val Gly Pro Gly Ala Pro Ala Ala Ala Ala
              20                  25                  30        
 Glu Pro Ala Arg Gly Asp Ala Gly Gly Glu Ala Gly Gly Cys His Pro
          35                  40                  45            
 Glu Ser Pro Ser Thr Thr Ser Ser Xaa Val Ile Pro Ser Thr Xaa Glu
      50                  55                  60                
 Ser Ser Ser Xaa Pro Ser Ser Pro Gly Phe Gly Ser Ser His Met Pro
  65                  70                  75                  80
 Gly Ser Thr Leu Met Pro Pro Trp Cys Thr Pro Arg Ser Gly Pro Arg
                  85                  90                  95    
 Thr His Ser Gln Arg Arg Glu Val Thr Cys Ala Trp Cys Ser Cys Trp
             100                 105                 110        
 Glu Pro Gly Arg Thr Ala Ala Ser Pro Ala Ala Ser Gln Thr Ser Ala
         115                 120                 125            
 Gly Ala Ser Xaa Pro Ser Pro Ala Ala Gln Ala Thr Ala Cys Pro Thr
     130                 135                 140                
 Asn Cys Ser Ser Ser Ser Gly Pro Glu Xaa Gly Gly Ala His Arg Asp
 145                 150                 155                 160
 His Ser Asn Arg Ala Arg Thr Ile Ser Thr Ser Ser Ala Pro Thr Xaa
                 165                 170                 175    
 Trp Thr Xaa Thr Ala Lys Leu Arg Pro Leu Asp Thr Pro Thr Leu Pro
             180                 185                 190        
 Gly Thr Ser Ser Trp Lys Thr Ser Cys Ser Val Glu Trp Ala Ala Ser
         195                 200                 205            
 Pro Thr Ser Thr Ser Ser Gly Gly Trp Arg Pro Phe Ser Ala Gly Arg
     210                 215                 220                
 Asn Ser Arg Lys Asp Ala Ser Gly Ser Leu Met Leu Lys Met Lys Asn
 225                 230                 235                 240
 His Leu Lys Leu Phe Asn Ile Ser Ser Ile Phe Arg Gly Glu
                 245                 250                



      <210> 2514
      <211> 135
      <212> PRT
      <213> Homo sapiens


      <400> 2514
 Leu Arg Ser Val Pro Cys Lys Asp Tyr Leu Thr Gln Asn His Tyr Ile
   1               5                  10                  15    
 Thr Ser Pro Leu Ser Glu Glu Glu Ala Ala Phe Pro Leu Ala Tyr Val
              20                  25                  30        
 Met Val Ile His Lys Asp Phe Asp Thr Phe Glu Arg Leu Phe Arg Ala
          35                  40                  45            
 Ile Tyr Met Pro Gln Asn Val Tyr Cys Val His Val Asp Glu Lys Ala
      50                  55                  60                
 Pro Ala Glu Tyr Lys Glu Ser Val Arg Gln Leu Leu Ser Cys Phe Gln
  65                  70                  75                  80
 Asn Ala Phe Ile Ala Ser Lys Thr Glu Ser Val Val Tyr Ala Gly Ile
                  85                  90                  95    
 Ser Arg Leu Gln Ala Asp Leu Asn Cys Leu Lys Asp Leu Val Ala Ser
             100                 105                 110        
 Glu Val Pro Trp Lys Tyr Val Ile Asn Thr Cys Gly Gln Asp Phe Pro
         115                 120                 125            
 Leu Thr Thr Thr Arg Pro Val
     130                 135



      <210> 2515
      <211> 142
      <212> PRT
      <213> Homo sapiens

      <220>
      <221> misc_feature
      <222> (1)...(142)
      <223> Xaa = any amino acid or symbol as shown in the table 8 as set forth in Example 2


      <400> 2515
 Lys Ala Glu Asn Lys Met Lys Ile Phe Gln Arg Lys Met Arg Tyr Trp
   1               5                  10                  15    
 Leu Leu Pro Pro Phe Leu Ala Ile Val Tyr Phe Cys Thr Ile Val Gln
              20                  25                  30        
 Gly Gln Val Ala Pro Pro Thr Arg Leu Arg Tyr Asn Val Ile Ser His
          35                  40                  45            
 Asp Ser Ile Gln Ile Ser Trp Lys Ala Pro Arg Gly Lys Phe Gly Gly
      50                  55                  60                
 Tyr Lys Leu Leu Val Thr Pro Thr Ser Gly Gly Lys Thr Asn Gln Leu
  65                  70                  75                  80
 Asn Leu Gln Asn Thr Ala Thr Lys Ala Ile Ile Gln Gly Leu Met Pro
                  85                  90                  95    
 Asp Gln Lys Phe Pro Gly Ser Ile Ile Gly Phe His Xaa Asp Lys Glu
             100                 105                 110        
 Ser Gln Pro Ala Gln Gly Pro Phe Arg Ile Xaa Gly Leu Glu Pro Cys
         115                 120                 125            
 Pro Ala Gln Val Ala Ala Thr Pro His Val Lys Ser Gly Lys
     130                 135                 140        



      <210> 2516
      <211> 210
      <212> PRT
      <213> Homo sapiens

      <220>
      <221> misc_feature
      <222> (1)...(210)
      <223> Xaa = any amino acid or symbol as shown in the table 8 as set forth in Example 2


      <400> 2516
 Met Thr Arg Met Leu Asn Met Leu Ile Val Phe Arg Phe Leu Arg Ile
   1               5                  10                  15    
 Ile Pro Ser Met Lys Pro Met Ala Val Val Ala Ser Thr Val Leu Gly
              20                  25                  30        
 Leu Val Gln Asn Met Arg Ala Phe Gly Gly Ile Leu Val Val Val Tyr
          35                  40                  45            
 Tyr Val Phe Ala Ile Ile Gly Ile Asn Leu Phe Arg Gly Val Ile Val
      50                  55                  60                
 Ala Leu Pro Gly Asn Ser Ser Leu Ala Pro Ala Asn Gly Ser Ala Pro
  65                  70                  75                  80
 Cys Gly Ser Phe Glu Gln Leu Glu Tyr Trp Ala Asn Asn Phe Asp Asp
                  85                  90                  95    
 Phe Xaa Ala Ala Leu Val Thr Leu Trp Asn Leu Met Val Val Asn Asn
             100                 105                 110        
 Trp Gln Val Phe Leu Asp Ala Tyr Arg Arg Tyr Ser Gly Pro Trp Ser
         115                 120                 125            
 Lys Ile Tyr Phe Val Leu Trp Trp Leu Val Ser Ser Val Ile Trp Val
     130                 135                 140                
 Asn Leu Phe Leu Ala Leu Ile Leu Glu Asn Phe Leu His Lys Trp Asp
 145                 150                 155                 160
 Pro Arg Ser His Leu Gln Pro Leu Ala Gly Thr Pro Glu Ala Thr Tyr
                 165                 170                 175    
 Gln Met Thr Val Glu Leu Leu Phe Arg Asp Ile Leu Glu Glu Pro Gly
             180                 185                 190        
 Glu Asp Glu Leu Thr Glu Arg Leu Ser Gln His Pro His Leu Trp Leu
         195                 200                 205            
 Cys Arg
     210



      <210> 2517
      <211> 114
      <212> PRT
      <213> Homo sapiens


      <400> 2517
 His Glu Gln Asp Ser Leu Ser Val Arg Tyr Ala Gly Leu Pro Asp Arg
   1               5                  10                  15    
 Ser Glu Met Ala Glu Val Glu Glu Thr Leu Lys Arg Leu Gln Ser Gln
              20                  25                  30        
 Lys Gly Val Gln Gly Ile Ile Val Val Asn Thr Glu Gly Ile Pro Ile
          35                  40                  45            
 Lys Ser Thr Met Asp Asn Pro Thr Thr Thr Gln Tyr Ala Ser Leu Met
      50                  55                  60                
 His Ser Phe Ile Leu Lys Ala Arg Ser Thr Val Arg Asp Ile Asp Pro
  65                  70                  75                  80
 Gln Asn Asp Leu Thr Phe Leu Arg Ile Arg Ser Lys Lys Asn Glu Ile
                  85                  90                  95    
 Met Val Ala Pro Asp Lys Asp Tyr Phe Leu Ile Val Ile Gln Asn Pro
             100                 105                 110        
 Thr Glu
        



      <210> 2518
      <211> 158
      <212> PRT
      <213> Homo sapiens

      <220>
      <221> misc_feature
      <222> (1)...(158)
      <223> Xaa = any amino acid or symbol as shown in the table 8 as set forth in Example 2


      <400> 2518
 Glu Lys Trp Tyr Trp Ile Pro Tyr Ser Leu Arg Phe Leu Ile Ile Phe
   1               5                  10                  15    
 Gly Lys Thr Gly Lys Xaa Pro Ser Asp Leu His Phe Ile Phe Phe Cys
              20                  25                  30        
 Asp Phe Lys Asp Met Glu Tyr Tyr Leu Val Lys Trp Lys Gly Trp Pro
          35                  40                  45            
 Asp Ser Thr Asn Thr Trp Glu Pro Leu Gln Asn Leu Lys Cys Pro Leu
      50                  55                  60                
 Leu Leu Gln Gln Phe Ser Asn Asp Lys His Asn Tyr Leu Ser Gln Val
  65                  70                  75                  80
 Lys Lys Gly Lys Ala Ile Thr Pro Lys Asp Asn Asn Lys Thr Leu Lys
                  85                  90                  95    
 Pro Ala Ile Ala Glu Tyr Ile Val Lys Lys Ala Lys Gln Arg Ile Ala
             100                 105                 110        
 Leu Gln Arg Trp Gln Asp Glu Leu Asn Arg Arg Lys Asn His Lys Gly
         115                 120                 125            
 Met Ile Phe Val Glu Asn Thr Val Asp Leu Glu Gly Pro Pro Ser Asp
     130                 135                 140                
 Phe Tyr Tyr Ile Asn Glu Tyr Lys Pro Ala Pro Gly Ile Ser
 145                 150                 155            



      <210> 2519
      <211> 125
      <212> PRT
      <213> Homo sapiens


      <400> 2519
 Gly Thr Ser Arg Val Val Gly Ala Val Met Ala Gly Val Leu Lys Lys
   1               5                  10                  15    
 Thr Thr Gly Leu Val Gly Leu Ala Val Cys Asn Thr Pro His Glu Arg
              20                  25                  30        
 Leu Arg Ile Leu Tyr Thr Lys Ile Leu Asp Val Leu Glu Glu Ile Pro
          35                  40                  45            
 Lys Asn Ala Ala Tyr Arg Lys Tyr Thr Glu Gln Ile Thr Asn Glu Lys
      50                  55                  60                
 Leu Ala Met Val Lys Ala Glu Pro Asp Val Lys Lys Leu Glu Asp Gln
  65                  70                  75                  80
 Leu Gln Gly Gly Gln Leu Glu Glu Val Ile Leu Gln Ala Glu His Glu
                  85                  90                  95    
 Leu Asn Leu Ala Arg Lys Met Arg Glu Trp Lys Leu Trp Glu Pro Leu
             100                 105                 110        
 Val Glu Glu Pro Pro Ala Asp Gln Trp Lys Trp Pro Ile
         115                 120                 125



      <210> 2520
      <211> 345
      <212> PRT
      <213> Homo sapiens


      <400> 2520
 Glu Asp Leu Leu Leu Leu Phe Ile Trp Ser Val Ser Phe Gln Gly Pro
   1               5                  10                  15    
 Arg Glu Glu Gly Met Arg Trp Ala Leu Leu Val Leu Leu Ala Phe Leu
              20                  25                  30        
 Ser Pro Ala Ser Gln Lys Ser Ser Asn Leu Glu Gly Arg Thr Lys Ser
          35                  40                  45            
 Val Thr Arg Gln Thr Gly Ser Ser Ala Glu Ile Thr Cys Asp Leu Thr
      50                  55                  60                
 Val Thr Asn Thr Phe Tyr Ile His Trp Tyr Leu His Gln Glu Gly Lys
  65                  70                  75                  80
 Ala Pro Gln Arg Leu Leu Tyr Tyr Asp Val Ser Thr Ala Arg Asp Val
                  85                  90                  95    
 Leu Glu Ser Gly Leu Ser Pro Gly Lys Tyr Tyr Thr His Thr Pro Arg
             100                 105                 110        
 Arg Trp Ser Trp Ile Leu Arg Leu Gln Asn Leu Ile Glu Asn Asp Ser
         115                 120                 125            
 Gly Val Tyr Tyr Cys Ala Thr Trp Asp Asn Arg Lys Glu Leu Leu Lys
     130                 135                 140                
 Lys Leu Phe Gly Ser Gly Thr Thr Leu Val Val Thr Asp Lys Gln Leu
 145                 150                 155                 160
 Asp Ala Asp Val Ser Pro Lys Pro Thr Ile Phe Leu Pro Ser Ile Ala
                 165                 170                 175    
 Glu Thr Lys Leu Gln Lys Ala Gly Thr Tyr Leu Cys Leu Leu Glu Lys
             180                 185                 190        
 Phe Phe Pro Asp Ile Ile Lys Ile His Trp Gln Glu Lys Lys Ser Asn
         195                 200                 205            
 Thr Ile Leu Gly Ser Gln Glu Gly Asn Thr Met Lys Thr Asn Asp Thr
     210                 215                 220                
 Tyr Met Lys Phe Ser Trp Leu Thr Val Pro Glu Glu Ser Leu Asp Lys
 225                 230                 235                 240
 Glu His Arg Cys Ile Val Arg His Glu Asn Asn Lys Asn Gly Ile Asp
                 245                 250                 255    
 Gln Glu Ile Ile Phe Pro Pro Ile Lys Thr Asp Val Thr Thr Val Asp
             260                 265                 270        
 Pro Lys Tyr Asn Tyr Ser Lys Asp Ala Asn Asp Val Ile Thr Met Asp
         275                 280                 285            
 Pro Lys Asp Asn Trp Ser Lys Asp Ala Asn Asp Thr Leu Leu Leu Gln
     290                 295                 300                
 Leu Thr Asn Thr Ser Ala Tyr Tyr Thr Tyr Leu Leu Leu Leu Leu Lys
 305                 310                 315                 320
 Ser Val Val Tyr Phe Ala Ile Ile Thr Cys Cys Leu Leu Arg Arg Thr
                 325                 330                 335    
 Ala Phe Cys Cys Asn Gly Gly Lys Ser
             340                 345



      <210> 2521
      <211> 609
      <212> PRT
      <213> Homo sapiens


      <400> 2521
 Asn Tyr Lys Thr Leu Ile Ile Ile Cys Ala Leu Phe Thr Leu Val Thr
   1               5                  10                  15    
 Val Leu Leu Trp Asn Lys Cys Ser Ser Asp Lys Ala Ile Gln Phe Pro
              20                  25                  30        
 Arg Arg Ser Ser Ser Gly Phe Arg Val Asp Gly Phe Glu Lys Arg Ala
          35                  40                  45            
 Ala Ala Ser Glu Ser Asn Asn Tyr Met Asn His Val Ala Lys Gln Gln
      50                  55                  60                
 Ser Glu Glu Ala Phe Pro Gln Glu Gln Gln Lys Ala Pro Pro Val Val
  65                  70                  75                  80
 Gly Gly Phe Asn Ser Asn Val Gly Ser Lys Val Leu Gly Leu Lys Tyr
                  85                  90                  95    
 Glu Glu Ile Asp Cys Leu Ile Asn Asp Glu His Thr Ile Lys Gly Arg
             100                 105                 110        
 Arg Glu Gly Asn Glu Val Phe Leu Pro Phe Thr Trp Val Glu Lys Tyr
         115                 120                 125            
 Phe Asp Val Tyr Gly Lys Val Val Gln Tyr Asp Gly Tyr Asp Arg Phe
     130                 135                 140                
 Glu Phe Ser His Ser Tyr Ser Lys Val Tyr Ala Gln Arg Ala Pro Tyr
 145                 150                 155                 160
 His Pro Asp Gly Val Phe Met Ser Phe Glu Gly Tyr Asn Val Glu Val
                 165                 170                 175    
 Arg Asp Arg Val Lys Cys Ile Ser Gly Val Glu Gly Val Pro Leu Ser
             180                 185                 190        
 Thr Gln Trp Gly Pro Gln Gly Tyr Phe Tyr Pro Ile Gln Ile Ala Gln
         195                 200                 205            
 Tyr Gly Leu Ser His Tyr Ser Lys Asn Leu Thr Glu Lys Pro Pro His
     210                 215                 220                
 Ile Glu Val Tyr Glu Thr Ala Glu Asp Arg Asp Lys Asn Lys Pro Asn
 225                 230                 235                 240
 Asp Trp Thr Val Pro Lys Gly Cys Phe Met Ala Asn Val Ala Asp Lys
                 245                 250                 255    
 Ser Arg Phe Thr Asn Val Lys Gln Phe Ile Ala Pro Glu Thr Ser Glu
             260                 265                 270        
 Gly Val Ser Leu Gln Leu Gly Asn Thr Lys Asp Phe Ile Ile Ser Phe
         275                 280                 285            
 Asp Leu Lys Phe Leu Thr Asn Gly Ser Val Ser Val Val Leu Glu Thr
     290                 295                 300                
 Thr Glu Lys Asn Gln Leu Phe Thr Ile His Tyr Val Ser Asn Ala Gln
 305                 310                 315                 320
 Leu Ile Ala Phe Lys Glu Arg Asp Ile Tyr Tyr Gly Ile Gly Pro Arg
                 325                 330                 335    
 Thr Ser Trp Ser Thr Val Thr Arg Asp Leu Val Thr Asp Leu Arg Lys
             340                 345                 350        
 Gly Val Gly Leu Ser Asn Thr Lys Ala Val Lys Pro Thr Lys Ile Met
         355                 360                 365            
 Pro Lys Lys Val Val Arg Leu Ile Ala Lys Gly Lys Gly Phe Leu Asp
     370                 375                 380                
 Asn Ile Thr Ile Ser Thr Thr Ala His Met Ala Ala Phe Phe Ala Ala
 385                 390                 395                 400
 Ser Asp Trp Leu Val Arg Asn Gln Asp Glu Lys Gly Gly Trp Pro Ile
                 405                 410                 415    
 Met Val Thr Arg Lys Leu Gly Glu Gly Phe Lys Ser Leu Glu Pro Gly
             420                 425                 430        
 Trp Tyr Ser Ala Met Ala Gln Gly Gln Ala Ile Ser Thr Leu Val Arg
         435                 440                 445            
 Ala Tyr Leu Leu Thr Lys Asp His Ile Phe Leu Asn Ser Ala Leu Arg
     450                 455                 460                
 Ala Thr Ala Pro Tyr Lys Phe Leu Ser Glu Gln His Gly Val Lys Ala
 465                 470                 475                 480
 Val Phe Met Asn Lys His Asp Trp Tyr Glu Glu Tyr Pro Thr Thr Pro
                 485                 490                 495    
 Ser Ser Phe Val Leu Asn Gly Phe Met Tyr Ser Leu Ile Gly Leu Tyr
             500                 505                 510        
 Asp Leu Lys Glu Thr Ala Gly Glu Lys Leu Gly Lys Glu Ala Arg Ser
         515                 520                 525            
 Leu Tyr Glu Arg Gly Met Glu Ser Leu Lys Ala Met Leu Pro Leu Tyr
     530                 535                 540                
 Asp Thr Gly Ser Gly Thr Ile Tyr Asp Leu Arg His Phe Met Leu Gly
 545                 550                 555                 560
 Ile Ala Pro Asn Leu Ala Arg Trp Asp Tyr His Thr Thr His Ile Asn
                 565                 570                 575    
 Gln Leu Gln Leu Leu Ser Thr Ile Asp Glu Ser Pro Ile Phe Lys Glu
             580                 585                 590        
 Phe Val Lys Arg Trp Lys Ser Tyr Leu Lys Gly Ser Arg Ala Lys His
         595                 600                 605            
 Asn
    



      <210> 2522
      <211> 1189
      <212> PRT
      <213> Homo sapiens


      <400> 2522
 Met Gly Leu Ser Glu Asp Pro Glu Leu Gln Pro Val Leu Ala Gly Leu
   1               5                  10                  15    
 Ser Leu Ser Met Tyr Leu Val Thr Val Leu Arg Asn Leu Leu Ser Ile
              20                  25                  30        
 Leu Ala Val Ser Ser Asp Ser His Leu His Thr Pro Met Tyr Phe Phe
          35                  40                  45            
 Leu Ser Asn Leu Cys Trp Ala Asp Ile Gly Phe Thr Ser Ala Thr Val
      50                  55                  60                
 Pro Lys Ile Ile Val Asp Met Gln Ser His Ser Arg Val Ile Ser Tyr
  65                  70                  75                  80
 Val Gly Cys Leu Thr Arg Met Ser Phe Leu Val Leu Phe Ala Cys Ile
                  85                  90                  95    
 Glu Asp Met Leu Leu Thr Val Met Ala Tyr Asp Cys Phe Val Ala Ile
             100                 105                 110        
 Cys Arg Pro Leu His Tyr Pro Val Ile Val Asn Ala His Leu Arg Val
         115                 120                 125            
 Phe Leu Val Leu Val Ser Phe Phe Leu Ser Leu Leu Asp Ser Gln Leu
     130                 135                 140                
 His Arg Ile Leu Leu Ser Tyr Cys Lys Ile Val Pro Ser Ile Leu Arg
 145                 150                 155                 160
 Ile Ser Thr Ser Asp Gly Lys Tyr Lys Ala Phe Ser Thr Cys Gly Ser
                 165                 170                 175    
 His Leu Ala Leu Val Cys Leu Phe Tyr Gly Ala Gly Ile Gly Val Tyr
             180                 185                 190        
 Leu Thr Ser Ala Val Ser Pro Pro Pro Arg Asn Gly Val Val Val Ser
         195                 200                 205            
 Val Met Tyr Thr Val Val Thr Pro Met Leu Asn Pro Phe Ile Tyr Ser
     210                 215                 220                
 Leu Arg Asn Arg Asp Ile Gln Ser Thr Leu Arg Arg Leu Leu Ser Arg
 225                 230                 235                 240
 Thr Val Glu Ser His Asp Leu Phe His Pro Phe Ser Cys Val Gly Lys
                 245                 250                 255    
 Arg Lys Ser Asn Gln Glu Cys Asp Thr Thr His Leu Asp Gly Cys Asp
             260                 265                 270        
 Lys Gln Thr Ser Ile Gly Glu Thr Arg Gly Lys Glu Tyr Thr Leu Cys
         275                 280                 285            
 Asp Ser Arg Ser Asn Leu Thr Gln Gly Tyr Lys Glu Gln Ile Gln Arg
     290                 295                 300                
 Met His Thr Cys Cys Asp Ile Ser Ser Asn Ile His Leu Gly Tyr Tyr
 305                 310                 315                 320
 Glu Tyr Tyr His Asn Val Asn Thr Pro Cys Asp Ile Arg Ser Asn Ile
                 325                 330                 335    
 Pro Leu Gln Tyr Trp Glu Pro Tyr His Thr Val Tyr Thr Pro Cys Asp
             340                 345                 350        
 Ile Arg Gly Arg Pro Met Asn Arg Gly Ser Arg Trp Pro Ser Val Ala
         355                 360                 365            
 Ala Val Thr Ala Gln His Lys Ala Lys His Phe Tyr Leu Leu Tyr His
     370                 375                 380                
 Ser Lys Ala Ala Ser Ala Cys Lys Gly Ser Asn Ser Pro Lys Gln Ala
 385                 390                 395                 400
 Pro Gly Pro Lys Glu Ser Pro Arg Gln Gly Asn Ile Glu Cys Gln Ala
                 405                 410                 415    
 Gln Gly Ile Arg Pro Ser Gly His Leu Asp Thr Val Arg Leu Gln Glu
             420                 425                 430        
 Leu Pro Pro Leu His Gln Glu Glu Leu Thr Tyr Gln Gly Asp Ser Leu
         435                 440                 445            
 Glu Thr Ala Cys Pro Ile Lys Ala Met Ile Pro Asn Leu Thr Leu Gln
     450                 455                 460                
 Leu Arg Glu Asp Ile Gln Thr Lys Gly Lys Glu Val Glu Asn Phe Glu
 465                 470                 475                 480
 Lys Asn Leu Glu Glu Cys Ile Thr Arg Ile Thr Asn Thr Glu Lys Cys
                 485                 490                 495    
 Leu Lys Glu Leu Met Glu Leu Lys Thr Lys Ala Arg Glu Leu Arg Lys
             500                 505                 510        
 Glu Cys Ser Ser Leu Arg Ser Arg Cys His Gln Leu Glu Glu Arg Val
         515                 520                 525            
 Ser Ala Met Glu Asp Glu Met Asn Glu Met Lys Trp Glu Gly Lys Phe
     530                 535                 540                
 Arg Glu Lys Arg Ile Lys Arg Asn Lys Gln Ser Leu Gln Glu Ile Trp
 545                 550                 555                 560
 Asp Tyr Val Lys Arg Pro Asn Leu Arg Leu Ile Gly Val Pro Glu Ser
                 565                 570                 575    
 Asp Gly Glu Asn Gly Thr Lys Leu Glu Asn Thr Leu Gln Asp Ile Val
             580                 585                 590        
 Gln Asn Phe Pro Asn Leu Ala Arg Gln Thr Asn Val Gln Ile Gln Glu
         595                 600                 605            
 Ile Gln Arg Thr Pro Gln Arg Tyr Ser Ser Arg Arg Ala Thr Pro Arg
     610                 615                 620                
 His Ile Ile Val Arg Phe Thr Lys Val Glu Met Lys Glu Lys Met Leu
 625                 630                 635                 640
 Arg Ala Ala Arg Glu Lys Glu Ile Gln Thr Thr Ile Arg Glu Tyr Tyr
                 645                 650                 655    
 Lys His Leu Tyr Ala Asn Lys Leu Glu Asn Leu Glu Glu Met Asp Lys
             660                 665                 670        
 Phe Leu Asp Thr Tyr Thr Leu Pro Arg Leu Asn Gln Glu Glu Val Glu
         675                 680                 685            
 Ser Leu Asn Arg Pro Ile Thr Gly Ser Glu Ile Val Ala Ile Ile Asn
     690                 695                 700                
 Ser Leu Pro Thr Lys Lys Ser Pro Gly Pro Asp Gly Phe Thr Ala Glu
 705                 710                 715                 720
 Phe Tyr Gln Arg Tyr Lys Glu Glu Leu Val Pro Phe Leu Leu Gln Leu
                 725                 730                 735    
 Phe Gln Ser Ile Glu Lys Glu Gly Ile Leu Pro Asn Ser Phe Tyr Glu
             740                 745                 750        
 Ala Ser Ile Ile Leu Ile Pro Lys Ala Gly Arg Asp Thr Thr Lys Lys
         755                 760                 765            
 Glu Asn Phe Arg Pro Ile Ser Leu Met Asn Val Asp Ala Lys Ile Leu
     770                 775                 780                
 Asn Lys Ile Leu Ala Lys Arg Ile Gln Gln His Ile Lys Lys Leu Ile
 785                 790                 795                 800
 His His Asp Gln Val Gly Phe Ile Pro Gly Met Gln Gly Trp Phe Asn
                 805                 810                 815    
 Ile Arg Lys Ser Ile Asn Val Ile Gln His Ile Asn Arg Ala Lys Asp
             820                 825                 830        
 Lys Asn His Met Ile Ile Ser Ile Asp Ala Glu Lys Ala Phe Asp Lys
         835                 840                 845            
 Ile Gln Gln Pro Phe Met Leu Lys Thr Leu Asn Lys Leu Glu Leu Glu
     850                 855                 860                
 Lys Thr Thr Leu Lys Phe Ile Trp Asn Gln Lys Arg Ala Arg Ile Ala
 865                 870                 875                 880
 Lys Ser Ile Leu Ser Gln Lys Asn Lys Ala Gly Gly Ile Thr Leu Pro
                 885                 890                 895    
 Asp Phe Lys Leu Tyr Tyr Lys Ala Thr Val Thr Lys Thr Ala Cys Leu
             900                 905                 910        
 Ala Pro His His Ser Pro Ser Thr Pro Ala Pro Gly Gly Asn Leu Arg
         915                 920                 925            
 Asn Pro Gln Ser Ser Asp Leu Leu Gln Val Thr Lys Gln Gln Gly Gln
     930                 935                 940                
 Ala Leu Ala Ile Gln Arg Glu Ala Pro Leu His Arg Ile Pro Ala Pro
 945                 950                 955                 960
 Glu Ala Ile Pro Trp Tyr Phe Gln Pro Gln Pro Ala Thr Gln Leu Gly
                 965                 970                 975    
 Ser Pro Pro Val Asp Pro Pro Ser Ser Ala Met Met Ala Glu Glu His
             980                 985                 990        
 Thr Asp Leu Glu Ala Gln Ile Val Lys Asp Ile His Cys Lys Glu Ile
         995                1000                1005            
 Asp Leu Val Asn Arg Asp Pro Lys Asn Ile Asn Glu Asp Ile Val Lys
    1010                1015                1020                
 Asn Ala Cys Leu Leu Gln Lys Asn Lys His Pro Phe Ala Pro Arg Leu
1025                1030                1035                1040
 Arg Leu His Asn Thr Gln Arg Asn Gln Met Pro Thr Ser Pro Thr Asn
                1045                1050                1055    
 Thr Cys Ser Arg Phe Val Leu Ile Arg Asp Thr Leu Leu His Lys Glu
            1060                1065                1070        
 Glu Thr Asp Leu Val Asp Phe Glu Asp Val Ile Ala Glu Pro Val Gly
        1075                1080                1085            
 Thr Tyr Ser Phe Asp Gly Val Trp Lys Val Ser Tyr Thr Thr Phe Thr
    1090                1095                1100                
 Val Ser Lys Tyr Trp Cys Tyr Arg Leu Leu Ser Thr Leu Leu Gly Val
1105                1110                1115                1120
 Pro Leu Ala Leu Leu Trp Gly Phe Leu Phe Ala Cys Ile Ser Phe Cys
                1125                1130                1135    
 His Ile Trp Ala Val Val Pro Cys Ile Lys Ser Tyr Leu Ile Glu Ile
            1140                1145                1150        
 Gln Cys Ile Ser His Ile Tyr Ser Leu Cys Ile Arg Thr Phe Cys Asn
        1155                1160                1165            
 Pro Leu Phe Ala Ala Leu Gly Gln Val Cys Ser Ser Ile Lys Val Val
    1170                1175                1180                
 Leu Arg Lys Glu Val
1185                



      <210> 2523
      <211> 378
      <212> PRT
      <213> Homo sapiens


      <400> 2523
 Leu Val Gly Ala Ser Met Trp Val Cys Ser Thr Leu Trp Arg Val Arg
   1               5                  10                  15    
 Thr Pro Pro Gly Ser Gly Gly Gly Leu Leu Pro Ala Ser Gly Cys His
              20                  25                  30        
 Gly Pro Ala Ala Ser Ser Tyr Ser Ala Ser Ala Glu Pro Ala Arg Val
          35                  40                  45            
 Arg Ala Leu Val Tyr Gly His His Gly Asp Pro Ala Lys Val Val Glu
      50                  55                  60                
 Leu Lys Asn Leu Glu Leu Ala Ala Val Arg Gly Ser Asp Val Arg Val
  65                  70                  75                  80
 Lys Met Leu Ala Ala Pro Ile Asn Pro Ser Asp Ile Asn Met Ile Gln
                  85                  90                  95    
 Gly Asn Tyr Gly Leu Leu Pro Glu Leu Pro Ala Val Gly Gly Asn Glu
             100                 105                 110        
 Gly Val Ala Gln Val Val Ala Val Gly Ser Asn Val Thr Gly Leu Lys
         115                 120                 125            
 Pro Gly Asp Trp Val Ile Pro Ala Asn Ala Gly Leu Gly Thr Trp Arg
     130                 135                 140                
 Thr Glu Ala Val Phe Ser Glu Glu Ala Leu Ile Gln Val Pro Ser Asp
 145                 150                 155                 160
 Ile Pro Leu Gln Ser Ala Ala Thr Leu Gly Val Asn Pro Cys Thr Ala
                 165                 170                 175    
 Tyr Arg Met Leu Met Asp Phe Glu Gln Leu Gln Pro Gly Asp Ser Val
             180                 185                 190        
 Ile Gln Asn Ala Ser Asn Ser Gly Val Gly Gln Ala Val Ile Gln Ile
         195                 200                 205            
 Ala Ala Ala Leu Gly Leu Arg Thr Ile Asn Val Val Arg Asp Arg Pro
     210                 215                 220                
 Asp Ile Gln Lys Leu Ser Asp Arg Leu Lys Ser Leu Gly Ala Glu His
 225                 230                 235                 240
 Val Ile Thr Glu Glu Glu Leu Arg Arg Pro Glu Met Lys Asn Phe Phe
                 245                 250                 255    
 Lys Asp Met Pro Gln Pro Arg Leu Ala Leu Asn Cys Val Gly Gly Lys
             260                 265                 270        
 Ser Ser Thr Glu Leu Leu Arg Gln Leu Ala Arg Gly Gly Thr Met Val
         275                 280                 285            
 Thr Tyr Gly Gly Met Ala Lys Gln Pro Val Val Ala Ser Val Ser Leu
     290                 295                 300                
 Leu Ile Phe Lys Asp Leu Lys Leu Arg Gly Phe Trp Leu Ser Gln Trp
 305                 310                 315                 320
 Lys Lys Asp His Ser Pro Asp Gln Phe Lys Glu Leu Ile Leu Thr Leu
                 325                 330                 335    
 Cys Asp Leu Ile Arg Arg Gly Gln Leu Thr Ala Pro Ala Cys Ser Gln
             340                 345                 350        
 Val Pro Leu Gln Asp Tyr Gln Ser Ala Leu Glu Ala Ser Met Lys Pro
         355                 360                 365            
 Phe Ile Ser Ser Lys Gln Ile Leu Thr Met
     370                 375            



      <210> 2524
      <211> 138
      <212> PRT
      <213> Homo sapiens


      <400> 2524
 Asn Leu Asp Cys Gly Leu Ser Tyr Arg Val Ile Ser Tyr Leu Lys Lys
   1               5                  10                  15    
 Leu Ser Gln Gln Thr Lys Leu Glu Ser Glu Arg Ile Leu Ala Ser Val
              20                  25                  30        
 Gly Lys Lys Pro Pro Gln Glu Ile Gly Ile Lys Val Lys Asn His Ser
          35                  40                  45            
 Gly Gly Gly Met Ser Leu Thr His Asn Lys Asn Phe Arg Lys Leu Leu
      50                  55                  60                
 Lys Glu Ile Thr Gly Glu Thr Ala Leu Arg Leu Thr Glu Leu Asn Thr
  65                  70                  75                  80
 Lys Glu Phe Ala Gly Phe Gln Ile Gly Leu Leu Asn Lys Asp Leu Lys
                  85                  90                  95    
 Pro Gln Thr Tyr Arg Asn Ala Tyr Asp Ile Pro Arg Arg Gly Leu Leu
             100                 105                 110        
 Asp Gln Leu Thr Arg Met Arg Ser Asn Leu Leu Lys Thr His Lys Phe
         115                 120                 125            
 Ile Val Gly Gln Asp Glu Asp Ser Leu His
     130                 135            



      <210> 2525
      <211> 130
      <212> PRT
      <213> Homo sapiens


      <400> 2525
 Lys Gly Gly Ser Met His Met Tyr Ala Lys Asn Phe Tyr Gly Gly Asn
   1               5                  10                  15    
 Gly Ile Val Gly Ala Gln Gly Gln Ile Phe Glu Ala Tyr Asn Met Ala
              20                  25                  30        
 Ala Leu Trp Lys Leu Pro Cys Ile Phe Ile Cys Glu Asn Asn Arg Tyr
          35                  40                  45            
 Gly Met Gly Thr Ser Val Glu Arg Ala Ala Pro Ser Thr Asp Tyr Tyr
      50                  55                  60                
 Lys Arg Gly Asp Phe Ile Pro Gly Leu Arg Val Asp Gly Met Asp Ile
  65                  70                  75                  80
 Leu Cys Val Arg Glu Ala Thr Arg Phe Ala Ala Ala Tyr Cys Arg Ser
                  85                  90                  95    
 Gly Lys Gly Pro Ile Leu Met Glu Leu Gln Thr Tyr Arg Tyr His Gly
             100                 105                 110        
 His Ser Met Ser Asp Pro Gly Val Ser Tyr Arg Thr Arg Glu Glu Ile
         115                 120                 125            
 Gln Glu
     130



      <210> 2526
      <211> 233
      <212> PRT
      <213> Homo sapiens


      <400> 2526
 Trp Ile Pro Gly Ala Cys Val Met Gln Glu Leu Glu Leu Pro Leu Cys
   1               5                  10                  15    
 Leu Gly Lys Ala Ser Gln Ala Gly Val Leu Leu Cys Lys Trp His Phe
              20                  25                  30        
 Ile Phe Pro Thr Gly Val Arg Ser Gln Thr Ile His Gln Trp Pro Ala
          35                  40                  45            
 Thr Leu Val Gln Pro Val Gly Ser Pro Leu Ser Leu Glu Cys Thr Val
      50                  55                  60                
 Glu Gly Thr Ser Asn Pro Asn Leu Tyr Trp Tyr Arg Gln Ala Ala Gly
  65                  70                  75                  80
 Arg Gly Leu Gln Leu Leu Phe Tyr Ser Val Gly Ile Gly Gln Ile Ser
                  85                  90                  95    
 Ser Glu Val Pro Gln Asn Leu Ser Ala Ser Arg Pro Gln Asp Arg Gln
             100                 105                 110        
 Phe Ile Leu Ser Ser Lys Lys Leu Leu Leu Ser Asp Ser Gly Phe Tyr
         115                 120                 125            
 Leu Cys Ala Trp Ser Ala Gly Leu Ala Gly Gly Pro Gly Glu Gln Tyr
     130                 135                 140                
 Phe Gly Pro Gly Thr Arg Leu Thr Val Thr Glu Asp Leu Lys Asn Val
 145                 150                 155                 160
 Phe Pro Pro Glu Val Ala Val Phe Glu Pro Ser Glu Ala Glu Ile Ser
                 165                 170                 175    
 His Thr Gln Lys Ala Thr Leu Val Cys Leu Arg Thr Gly Phe Tyr Pro
             180                 185                 190        
 Asp His Val Glu Leu Ser Trp Trp Val Asn Gly Lys Glu Val His Ser
         195                 200                 205            
 Gly Val Ser Thr Asp Pro Gln Pro Leu Lys Glu Gln Pro Ala Leu Asn
     210                 215                 220                
 Asp Ser Arg Tyr Cys Leu Ser Ser Arg
 225                 230            



      <210> 2527
      <211> 58
      <212> PRT
      <213> Homo sapiens

      <220>
      <221> misc_feature
      <222> (1)...(58)
      <223> Xaa = any amino acid or symbol as shown in the table 8 as set forth in Example 2


      <400> 2527
 Asn Tyr Ser Leu Ser Val Tyr Leu Val Arg Gln Leu Thr Ala Gly Thr
   1               5                  10                  15    
 Leu Leu Gln Lys Leu Arg Ala Lys Gly Ile Arg Asn Pro Asp His Ser
              20                  25                  30        
 Arg Ala Leu Ser Glu Xaa His Leu Ser Ser Leu Pro His Leu Ile Trp
          35                  40                  45            
 Ile Gln Val Phe Leu Ala Leu Gln Pro Ser
      50                  55            



      <210> 2528
      <211> 82
      <212> PRT
      <213> Homo sapiens


      <400> 2528
 Leu Val Ser Val Ser Lys Lys Ser Val Ser Tyr Met Val Ser Lys Glu
   1               5                  10                  15    
 Gly Gly Gly Asn Ile Ser Val Ile Val Leu Gly Gly Ala Lys Glu Ser
              20                  25                  30        
 Leu Asp Ala His Pro Gly Lys Phe Thr Leu Phe Ile Arg Gln Arg Lys
          35                  40                  45            
 Gly Phe Val Lys Ile Ala Leu Thr His Gly Ala Ser Leu Val Pro Val
      50                  55                  60                
 Val Ser Phe Gly Glu Asn Glu Leu Phe Lys Gln Thr Asp Asn Pro Glu
  65                  70                  75                  80
 Gly Ala
        



      <210> 2529
      <211> 136
      <212> PRT
      <213> Homo sapiens


      <400> 2529
 Phe Leu Pro Ser Asp Pro Asn His Phe Ile Ile Gly Thr Asp Met Gly
   1               5                  10                  15    
 Leu Ile Ser His Gly Thr Arg Gln Asp Leu Arg Val Ala Pro Lys Leu
              20                  25                  30        
 Phe Lys Pro Gln Gln His Gly Ile Arg Pro Val Lys Val Asn Val Ile
          35                  40                  45            
 Asp Phe Ser Pro Phe Gly Glu Pro Ile Phe Leu Ala Gly Cys Ser Asp
      50                  55                  60                
 Gly Ser Ile Arg Leu His Gln Leu Ser Ser Ala Phe Pro Leu Leu Gln
  65                  70                  75                  80
 Trp Asp Ser Ser Thr Asp Ser His Ala Val Thr Gly Leu Gln Trp Ser
                  85                  90                  95    
 Pro Thr Arg Pro Ala Val Phe Leu Val Gln Asp Asp Thr Ser Asn Ile
             100                 105                 110        
 Tyr Ile Trp Asp Leu Leu Gln Ser Asp Leu Gly Pro Val Ala Lys Gln
         115                 120                 125            
 Gln Val Ser Pro Asn Arg Leu Val
     130                 135    



      <210> 2530
      <211> 43
      <212> PRT
      <213> Homo sapiens


      <400> 2530
 Gln Glu Lys Asp Ser Leu Thr Pro Asp Leu Pro Pro Asn Ile Thr Leu
   1               5                  10                  15    
 Ser Trp Gln Gln Leu His Pro Val Pro His Pro Ser Pro Thr Thr Phe
              20                  25                  30        
 Leu Lys Ile Lys Leu Pro Ser Pro Gly Leu Ser
          35                  40            



      <210> 2531
      <211> 275
      <212> PRT
      <213> Homo sapiens


      <400> 2531
 Met Ala Cys Pro Gly Phe Leu Trp Ala Leu Val Ile Ser Thr Cys Leu
   1               5                  10                  15    
 Glu Phe Ser Met Ala Gln Thr Val Thr Gln Ser Gln Pro Glu Met Ser
              20                  25                  30        
 Val Gln Glu Ala Glu Thr Val Thr Leu Ser Cys Thr Tyr Asp Thr Ser
          35                  40                  45            
 Glu Ser Asp Tyr Tyr Leu Phe Trp Tyr Lys Gln Pro Pro Ser Arg Gln
      50                  55                  60                
 Met Ile Leu Val Ile Arg Gln Glu Ala Tyr Lys Gln Gln Asn Ala Thr
  65                  70                  75                  80
 Glu Asn Arg Phe Ser Val Asn Phe Gln Lys Ala Ala Lys Ser Phe Ser
                  85                  90                  95    
 Leu Lys Ile Ser Asp Ser Gln Leu Gly Asp Ala Ala Met Tyr Phe Cys
             100                 105                 110        
 Ala Tyr Arg Ser Gly Arg Asp Asp Lys Ile Ile Phe Gly Lys Gly Thr
         115                 120                 125            
 Arg Leu His Ile Leu Pro Asn Ile Gln Asn Pro Asp Pro Ala Val Tyr
     130                 135                 140                
 Gln Leu Arg Asp Ser Lys Ser Ser Asp Lys Ser Val Cys Leu Phe Thr
 145                 150                 155                 160
 Asp Phe Asp Ser Gln Thr Asn Val Ser Gln Ser Lys Asp Ser Asp Val
                 165                 170                 175    
 Tyr Ile Thr Asp Lys Thr Val Leu Asp Met Arg Ser Met Asp Phe Lys
             180                 185                 190        
 Ser Asn Ser Ala Val Ala Trp Ser Asn Lys Ser Asp Phe Ala Cys Ala
         195                 200                 205            
 Asn Ala Phe Asn Asn Ser Ile Ile Pro Glu Asp Thr Phe Phe Pro Ser
     210                 215                 220                
 Pro Glu Ser Ser Cys Asp Val Lys Leu Val Glu Lys Ser Phe Glu Thr
 225                 230                 235                 240
 Asp Thr Asn Leu Asn Phe Gln Asn Leu Ser Val Ile Gly Phe Arg Ile
                 245                 250                 255    
 Leu Leu Leu Lys Val Ala Gly Phe Asn Leu Leu Met Thr Leu Arg Leu
             260                 265                 270        
 Trp Ser Ser
         275



      <210> 2532
      <211> 133
      <212> PRT
      <213> Homo sapiens


      <400> 2532
 Pro Val Ala Arg Ala Leu Glu Lys Met Leu Val Leu Asn Cys Ser Thr
   1               5                  10                  15    
 Lys Leu Leu Ile Leu Glu Lys Thr Leu Lys Ser Cys Phe Pro Glu Ser
              20                  25                  30        
 Leu Lys Val Tyr Gly Ala Val Met Asn Ile Asn Arg Gly Asn Pro Phe
          35                  40                  45            
 Gln Lys Glu Val Val Leu Asp Ser Trp Pro Asp Phe Ile Ala Val Ile
      50                  55                  60                
 Thr Arg Arg Gln Arg Glu Ala Glu Thr Asp Asn Leu Asp His Tyr Thr
  65                  70                  75                  80
 Asn Ala Tyr Ala Val Phe Tyr Lys Asp Val Arg Ala Tyr Arg Gln Leu
                  85                  90                  95    
 Leu Glu Glu Cys Asp Ala Phe Asn Trp Asp Gln Val Phe Gln Ile Gln
             100                 105                 110        
 Gly Leu Gln Ser Glu Leu Tyr Asp Val Ser Lys Ala Val Asp Asn Ser
         115                 120                 125            
 Lys Gln Leu Asn Ile
     130            



      <210> 2533
      <211> 80
      <212> PRT
      <213> Homo sapiens


      <400> 2533
 Asp Tyr Gly Gly Phe Gly Leu Arg Pro Arg Pro Gly Pro Pro Ala Ala
   1               5                  10                  15    
 Asp Pro Ala Pro Glu Val Leu Ala Arg Ala Val Cys Tyr Pro Pro Ser
              20                  25                  30        
 Pro Arg Pro Pro Leu Arg Pro Gly Ala Trp Ser Trp Arg Val Thr Met
          35                  40                  45            
 Arg Leu Gly Leu Cys Val Val Ala Leu Val Leu Ser Trp Thr His Leu
      50                  55                  60                
 Thr Ile Ser Ser Arg Gly Ile Lys Gly Lys Arg Gln Arg Arg Ile Ser
  65                  70                  75                  80





      <210> 2534
      <211> 168
      <212> PRT
      <213> Homo sapiens


      <400> 2534
 Ala Ser Ala Leu Leu Phe Val Val Gly Phe Ala Glu Ser Leu Arg Glu
   1               5                  10                  15    
 Phe Thr Ala Asp Cys Pro Pro Tyr Lys Cys Pro Val Ala Pro Glu Pro
              20                  25                  30        
 Leu Pro Gln Pro Leu Ser Pro Leu Gln Cys Pro Gly Glu Glu Ser Thr
          35                  40                  45            
 Asp Ser Pro Phe Ser Leu Pro Thr Val Gln Pro Val Lys Ser Arg Cys
      50                  55                  60                
 Ser Pro Phe Ile Glu Glu Ser Pro Arg Ala Asn Arg Ser Ile Pro Ala
  65                  70                  75                  80
 Phe Gly Ser His Leu Glu Cys Ala Ser Cys Ser Ser Arg Ser Phe His
                  85                  90                  95    
 Gly Pro Pro Pro Cys Cys Leu Trp Gly Leu Pro Leu Ser Ala Pro Ser
             100                 105                 110        
 Pro His Val Leu His Pro Pro Ala Ser Ala Ala Ile Gly Pro Ala Cys
         115                 120                 125            
 Cys Val Thr Ser Leu Cys Pro Gly Ala Pro Gln Ala Gln Arg Pro Arg
     130                 135                 140                
 Lys Val Asp Gln Thr Ser Ser Ala Pro Gly Ala Gly Pro Gly Thr Gln
 145                 150                 155                 160
 Asp Gly Asn Glu Arg Pro Asn Pro
                 165            



      <210> 2535
      <211> 212
      <212> PRT
      <213> Homo sapiens


      <400> 2535
 Arg Ala Pro Gly Gly Gly Gly Met Glu Ala Ala Ala Gln Pro Gly Asn
   1               5                  10                  15    
 Leu Ala Gly Val Arg His Ile Ile Leu Val Leu Ser Gly Lys Gly Gly
              20                  25                  30        
 Val Gly Lys Ser Thr Ile Ser Thr Glu Leu Ala Leu Ala Leu Arg His
          35                  40                  45            
 Ala Gly Lys Asn Ala Leu Ile Lys Gln Phe Val Ser Asp Val Ala Trp
      50                  55                  60                
 Gly Glu Leu Asp Tyr Leu Val Val Asp Thr Pro Pro Gly Thr Ser Asp
  65                  70                  75                  80
 Glu His Met Ala Thr Ile Glu Ala Leu Arg Pro Tyr Gln Pro Leu Gly
                  85                  90                  95    
 Ala Leu Val Val Thr Thr Pro Gln Ala Val Ser Val Gly Asp Val Arg
             100                 105                 110        
 Arg Glu Leu Thr Phe Cys Arg Lys Thr Gly Leu Arg Val Met Gly Ile
         115                 120                 125            
 Val Glu Asn Met Ser Gly Phe Thr Cys Pro His Cys Thr Glu Cys Thr
     130                 135                 140                
 Ser Val Phe Ser Arg Gly Gly Gly Glu Glu Leu Ala Gln Leu Ala Gly
 145                 150                 155                 160
 Val Pro Phe Leu Gly Ser Val Pro Leu Asp Pro Ala Leu Met Arg Thr
                 165                 170                 175    
 Leu Glu Glu Gly His Asp Phe Ile Gln Glu Phe Pro Gly Ser Pro Ala
             180                 185                 190        
 Phe Ala Ala Leu Thr Ser Ile Ala Gln Lys Ile Leu Asp Ala Thr Pro
         195                 200                 205            
 Ala Cys Leu Pro
     210        



      <210> 2536
      <211> 108
      <212> PRT
      <213> Homo sapiens


      <400> 2536
 Met Leu Trp Phe Ser Gly Val Gly Ala Leu Ala Glu Arg Tyr Cys Arg
   1               5                  10                  15    
 Arg Ser Pro Gly Ile Thr Cys Cys Val Leu Leu Leu Leu Asn Cys Ser
              20                  25                  30        
 Gly Val Pro Met Ser Leu Ala Ser Ser Phe Leu Thr Gly Ser Val Ala
          35                  40                  45            
 Lys Cys Glu Asn Glu Gly Glu Val Leu Gln Ile Pro Phe Ile Thr Asp
      50                  55                  60                
 Asn Pro Cys Ile Met Cys Val Cys Leu Asn Lys Glu Val Thr Cys Lys
  65                  70                  75                  80
 Arg Glu Lys Cys Pro Val Leu Ser Arg Asp Cys Ala Leu Ala Ile Lys
                  85                  90                  95    
 Gln Arg Gly Ala Cys Cys Glu Gln Cys Lys Gly Cys
             100                 105            



      <210> 2537
      <211> 95
      <212> PRT
      <213> Homo sapiens


      <400> 2537
 Asp Ile Ser Phe Met Ala Trp Ala Leu Leu Leu Leu Thr Leu Leu Thr
   1               5                  10                  15    
 Gln Gly Thr Gly Ser Trp Ala Gln Ser Ala Leu Thr Gln Pro Ala Ser
              20                  25                  30        
 Val Ser Gly Ser Pro Gly Gln Ser Ile Thr Ile Ser Cys Thr Gly Thr
          35                  40                  45            
 Ser Ser Asp Val Gly Gly Tyr Asn Tyr Val Ser Trp Tyr Gln Gln His
      50                  55                  60                
 Pro Gly Lys Ala Pro Lys Leu Met Ile Tyr Glu Glu Ser Pro Pro Val
  65                  70                  75                  80
 His Ile Gly Pro Val Phe Val Ser Arg Thr Asn Gln Ser His Pro
                  85                  90                  95



      <210> 2538
      <211> 872
      <212> PRT
      <213> Homo sapiens

      <220>
      <221> misc_feature
      <222> (1)...(872)
      <223> Xaa = any amino acid or symbol as shown in the table 8 as set forth in Example 2


      <400> 2538
 Trp Leu Leu Gln Lys His Lys Leu His Val Ser Arg Xaa Leu Gly Leu
   1               5                  10                  15    
 Pro Asp Thr Ser Trp Ile Leu Pro Ser Arg Pro Asp Ala Gly Gly Arg
              20                  25                  30        
 Phe Pro Ile Arg Thr Pro Pro Cys Val Leu Val Val His Lys Pro Ser
          35                  40                  45            
 Arg His Cys Arg Glu Trp Thr Ala Asn Thr Val Leu Pro Lys Gly Ala
      50                  55                  60                
 Leu Ala Lys Trp Leu Leu Glu Pro Lys Ala Asp Leu Gln Gly Trp His
  65                  70                  75                  80
 Leu Pro Ala Asp Gly Gln Tyr Thr Lys Pro Ser Ile Ser Tyr Asn Ile
                  85                  90                  95    
 Lys Leu Tyr Ile Asn Cys Tyr Asn Arg Thr Val Thr Thr Ala Ala Gln
             100                 105                 110        
 His Gln Gln Val Gln Arg Lys His Gly Ala Ser Ile Phe Leu Ala Glu
         115                 120                 125            
 Asn Val Ala Val Arg Glu Lys Asp Lys Glu Glu Arg Lys Val Thr Arg
     130                 135                 140                
 Ala Pro Thr Glu Gln Ala Trp Thr Ala Gly Ser Trp Ile Glu Thr Ala
 145                 150                 155                 160
 Tyr Arg Glu Ile Lys Gly Val Gly Gln Glu Ser Val Cys Ile Thr Val
                 165                 170                 175    
 Met His Leu Glu Glu Leu Val Tyr Glu Leu Ala Trp Ile Ile Met Ser
             180                 185                 190        
 Ala Val Val Glu Ala Phe Asp Pro Val Ala Pro Ser Ser Lys Cys Arg
         195                 200                 205            
 Leu Asn Pro Asp Pro Asp Pro Tyr Cys Cys Thr Pro Tyr Thr Leu His
     210                 215                 220                
 Thr Ser Pro Pro Pro Pro Pro Ser Cys Cys Thr Pro Tyr Thr Leu His
 225                 230                 235                 240
 Thr Gly Pro Pro Pro Gln Thr Pro Phe Cys Cys Thr Pro Tyr Thr Leu
                 245                 250                 255    
 Asp Thr Ser Pro Ser Pro Gln Thr His Ser Cys Cys Thr Pro Tyr Thr
             260                 265                 270        
 Leu His Thr Val Pro Thr Phe His Leu Pro Ala Ala His Pro Ile His
         275                 280                 285            
 Leu His Thr Ile Pro Pro Pro Gln Thr Gln Gly Gln Gly Phe Val Ser
     290                 295                 300                
 Glu Asp Glu Tyr Leu Glu Ile Ser Asp Ile Lys Arg Asp Gln Ser Gly
 305                 310                 315                 320
 Glu Tyr Glu Cys Ser Ala Leu Asn Asp Val Ala Ala Pro Asp Val Arg
                 325                 330                 335    
 Lys Val Lys Ile Thr Val Asn Tyr Pro Pro Tyr Ile Ser Lys Ala Lys
             340                 345                 350        
 Asn Thr Gly Val Ser Val Gly Gln Lys Gly Ile Leu Ser Cys Glu Ala
         355                 360                 365            
 Ser Ala Val Pro Met Ala Glu Phe Gln Trp Phe Lys Glu Glu Thr Arg
     370                 375                 380                
 Leu Ala Thr Gly Leu Asp Gly Met Arg Ile Glu Asn Lys Gly Arg Met
 385                 390                 395                 400
 Ser Thr Leu Thr Phe Phe Asn Val Ser Glu Lys Asp Tyr Gly Asn Tyr
                 405                 410                 415    
 Thr Cys Val Ala Thr Asn Lys Leu Gly Asn Thr Asn Ala Ser Ile Thr
             420                 425                 430        
 Leu Tyr Val Asp His Ile Val Gly Ser Lys Ala Leu Leu Ser Lys Cys
         435                 440                 445            
 Lys Arg Thr Glu Ile Ile Thr Asn Tyr Leu Ser Asp His Ser Ala Ile
     450                 455                 460                
 Lys Leu Glu Leu Arg Ile Lys Asn Leu Thr Gln Asn His Ser Thr Thr
 465                 470                 475                 480
 Trp Lys Leu Asn Asn Pro Leu Leu Asn Asp Tyr Trp Val His Asn Glu
                 485                 490                 495    
 Met Lys Ala Glu Ile Lys Met Phe Phe Glu Thr Asn Lys Asn Lys Asp
             500                 505                 510        
 Thr Thr Tyr Gln Asn Leu Trp Asp Ala Phe Lys Ala Val Cys Arg Gly
         515                 520                 525            
 Lys Phe Ile Ala Leu Asn Ala His Lys Arg Lys Gln Glu Arg Ser Lys
     530                 535                 540                
 Ile Asp Thr Leu Thr Ser Gln Leu Lys Glu Leu Glu Lys Gln Glu Gln
 545                 550                 555                 560
 Thr His Ser Lys Ala Asn Arg Arg Gln Glu Ile Thr Lys Ile Arg Ala
                 565                 570                 575    
 Glu Leu Lys Glu Ile Glu Thr Gln Lys Thr Leu Gln Lys Ile Asn Glu
             580                 585                 590        
 Ser Arg Ser Trp Phe Phe Glu Arg Ile Asn Lys Ile Asp Arg Leu Leu
         595                 600                 605            
 Ala Arg Leu Ile Lys Lys Lys Arg Glu Lys Asn Gln Ile Asp Ala Ile
     610                 615                 620                
 Lys Asn Asp Lys Gly Asp Ile Thr Thr Tyr Pro Thr Glu Ile Gln Thr
 625                 630                 635                 640
 Thr Ile Arg Glu Tyr Tyr Lys His Leu Tyr Ala Asn Lys Leu Glu Asn
                 645                 650                 655    
 Leu Glu Glu Met Asp Lys Phe Leu Asp Thr Tyr Thr Leu Pro Arg Leu
             660                 665                 670        
 Asn Gln Glu Glu Val Glu Ser Gln Asn Arg Pro Ile Thr Gly Ser Glu
         675                 680                 685            
 Ile Val Ala Ile Ile Asn Ser Leu Pro Thr Lys Lys Ser Pro Gly Pro
     690                 695                 700                
 Asp Gly Phe Thr Ala Glu Phe Tyr Gln Arg Tyr Lys Glu Glu Leu Val
 705                 710                 715                 720
 Ile Tyr Arg Phe Asn Ala Val Pro Ile Lys Leu Pro Met Pro Phe Phe
                 725                 730                 735    
 Thr Glu Leu Glu Lys Thr Thr Leu Lys Phe Ile Trp Asn Gln Lys Arg
             740                 745                 750        
 Ala Arg Ile Ala Lys Ser Val Leu Ser Gln Lys Asn Lys Ala Gly Gly
         755                 760                 765            
 Ile Thr Leu Pro Asp Phe Lys Leu Tyr Tyr Lys Ala Thr Val Thr Lys
     770                 775                 780                
 Thr Ala Trp Ile Lys Ser Leu Leu Thr Trp Ala Ile Ile Cys Tyr Asn
 785                 790                 795                 800
 Leu Gln His Thr His Gly Pro Thr His Phe Ser Ser Phe Ile Cys Ser
                 805                 810                 815    
 His Ser His Ser Thr Ser Ile Tyr Trp Glu Gln Ile Ala Asp Glu Ala
             820                 825                 830        
 Leu Asp Tyr Ser Asn Glu Thr Pro Val Ala His Arg Ser Asp His Ala
         835                 840                 845            
 Gly Leu Ser Arg Ser Asp Lys Asn Glu Asn Pro Val Gly Ile Phe Glu
     850                 855                 860                
 Gly Gly Ser Arg Thr Ala Ser Trp
 865                 870        



      <210> 2539
      <211> 347
      <212> PRT
      <213> Homo sapiens


      <400> 2539
 Ala Pro Val Thr Lys Arg Lys Glu Val Phe Ala Lys Asp Ser Lys Gly
   1               5                  10                  15    
 Ser Ala Leu Asp Ala Gly Arg Asp Pro Lys Arg Pro Ala Leu Pro Glu
              20                  25                  30        
 Thr Leu Cys Glu Ser Gly Trp Ala Ser Asn Thr Ala Pro Thr Thr Pro
          35                  40                  45            
 Pro Gln Pro Gly Trp Cys Leu Cys Gly Lys Asp Phe Lys Ser Ser Cys
      50                  55                  60                
 Gln Thr Pro Gly Arg Glu Lys Glu Arg Arg Leu Ala Thr Met His Gly
  65                  70                  75                  80
 Ser Cys Ser Phe Leu Met Leu Leu Leu Pro Leu Leu Leu Leu Leu Val
                  85                  90                  95    
 Ala Thr Thr Gly Pro Val Gly Ala Leu Thr Asp Glu Glu Lys Arg Leu
             100                 105                 110        
 Met Val Glu Leu His Asn Leu Tyr Arg Ala Gln Val Ser Pro Thr Ala
         115                 120                 125            
 Ser Asp Met Leu His Met Arg Trp Asp Glu Glu Leu Ala Ala Phe Ala
     130                 135                 140                
 Lys Ala Tyr Ala Arg Gln Cys Val Trp Gly His Asn Lys Glu Arg Gly
 145                 150                 155                 160
 Arg Arg Gly Glu Asn Leu Phe Ala Ile Thr Asp Glu Gly Met Asp Val
                 165                 170                 175    
 Pro Leu Ala Met Glu Glu Trp His His Glu Arg Glu His Tyr Asn Leu
             180                 185                 190        
 Ser Ala Ala Thr Cys Ser Pro Gly Gln Met Cys Gly His Tyr Thr Gln
         195                 200                 205            
 Val Val Trp Ala Lys Thr Glu Arg Ile Gly Cys Gly Ser His Phe Cys
     210                 215                 220                
 Glu Lys Leu Gln Gly Val Glu Glu Thr Asn Ile Glu Leu Leu Val Cys
 225                 230                 235                 240
 Asn Tyr Glu Pro Pro Gly Asn Val Lys Gly Lys Arg Pro Tyr Gln Glu
                 245                 250                 255    
 Gly Thr Pro Cys Ser Gln Cys Pro Ser Gly Tyr His Cys Lys Asn Ser
             260                 265                 270        
 Leu Cys Glu Pro Ile Gly Ser Pro Glu Asp Ala Gln Asp Leu Pro Tyr
         275                 280                 285            
 Leu Val Thr Glu Ala Pro Ser Phe Arg Ala Thr Glu Ala Ser Asp Ser
     290                 295                 300                
 Arg Lys Met Gly Ala Glu Gly Pro Asp Lys Pro Ser Val Val Ser Gly
 305                 310                 315                 320
 Leu Asn Ser Gly Pro Gly His Val Trp Gly Pro Leu Leu Gly Leu Leu
                 325                 330                 335    
 Leu Leu Pro Pro Leu Val Leu Ala Gly Ile Phe
             340                 345        



      <210> 2540
      <211> 50
      <212> PRT
      <213> Homo sapiens


      <400> 2540
 Thr Arg Arg Gly Gly Cys Pro Glu Glu Lys Val Glu Glu Leu Lys Leu
   1               5                  10                  15    
 Trp Glu Lys Cys Val His Ser Leu Tyr Arg His Ser Ser Ser Ala Leu
              20                  25                  30        
 Asp Leu Gln Lys Ile Pro Gly Ala Ile Tyr Ile Pro Ser Gly Phe Pro
          35                  40                  45            
 Leu Arg
      50



      <210> 2541
      <211> 899
      <212> PRT
      <213> Homo sapiens


      <400> 2541
 Met Leu Gly Lys Ser Leu Asp Leu Leu Asp Asp Ser Leu Ala Glu Thr
   1               5                  10                  15    
 Gly Ser Lys Glu Ser Ile Pro Gln Thr Glu Val Ile Ala Ile Arg Gly
              20                  25                  30        
 Arg Arg Gln Thr Phe Gln Gly Leu Lys Ser Cys Asp Lys Glu Phe Gly
          35                  40                  45            
 Val Tyr Ala Glu Cys Asp Arg Glu Pro Ala Asn Val Phe His Arg Ala
      50                  55                  60                
 Ser Gly Lys Glu Gly Lys Thr Gly Gly Lys Arg Asn Thr Gln Thr Ser
  65                  70                  75                  80
 Glu Gly Ser Arg Gln Phe Thr His Phe Tyr Ser Leu Thr Phe Ser Ala
                  85                  90                  95    
 Ser Lys Cys Gln Val Val Glu Leu Gln Arg Glu Thr Glu Val Ala Gly
             100                 105                 110        
 Tyr Glu Asn Arg Gln His Ser Phe Phe Pro Pro Cys Gly Val Phe Pro
         115                 120                 125            
 Asp Lys Lys Ala Gly Leu Asn Pro Gly Cys Cys Ser Ser Arg Pro His
     130                 135                 140                
 Glu Arg Leu Asp Trp Leu Ile Glu Arg Pro Lys Gly Gly Arg Arg Ala
 145                 150                 155                 160
 Glu Leu Ser Ile Arg Ser Leu Ala Leu Pro Leu Pro Gln His Cys Gly
                 165                 170                 175    
 Ser Asp Asn Asp Trp Ile Pro Leu Gln Leu Arg Leu Leu Ser Arg Ala
             180                 185                 190        
 Ser Phe His Ser Gly Pro Lys Leu Thr Glu His Phe Gln Leu Pro Trp
         195                 200                 205            
 Gln Lys Glu Asn Gly Ala Lys Ala Asn Asn Ser Ile Ala Leu Thr Ala
     210                 215                 220                
 Phe Thr Gly Glu Ser Asp Glu Met Pro Ser Tyr Ser Thr Ala Gly Ser
 225                 230                 235                 240
 Ser Cys Gln Asn Ile Cys Trp Met Ala Leu Met Thr Thr Thr Thr Thr
                 245                 250                 255    
 Asp Cys Val Gly Glu Asn Thr Glu Lys Leu Lys Trp Glu Asn Ser Leu
             260                 265                 270        
 Thr Pro Leu Ala Glu Pro Leu Glu Ala Asn Lys Ser Lys Ile Lys Ala
         275                 280                 285            
 Pro Glu Asn Leu Val Ser Val Leu Arg Arg Ser Thr Leu Gln Pro Tyr
     290                 295                 300                
 Phe Asn Glu Gln Val Leu Asn Phe Phe Ala Gln Ile Ile Ser Ser Ser
 305                 310                 315                 320
 Cys Val Ile Trp Lys Glu Asn Lys Thr Ala Trp Asp Thr Ala Lys Ser
                 325                 330                 335    
 Gly Asn Arg Pro Ser Gly Phe Pro Asp Ser Ile Lys Glu Thr Glu Thr
             340                 345                 350        
 His Gln Ile Gly Ser Leu Leu Trp Ser Glu Cys Leu Cys Lys Pro Gln
         355                 360                 365            
 Ile His Thr Ser Asn Pro Asn Pro Gln Cys Gly Gly Ile Gly Arg Glu
     370                 375                 380                
 Arg Lys Glu Met Ser Leu Gly Ser Lys Cys Gly Lys Leu Cys Arg Asp
 385                 390                 395                 400
 Ser Gln Gly Glu Arg Ser Phe Pro Leu Ser Lys Ala Ala Phe Val Thr
                 405                 410                 415    
 Arg Cys Cys Ile Val Thr Glu Ser Asn Glu Leu Ser Asp Ala Thr Val
             420                 425                 430        
 Gln Lys Glu Leu Ala Gly Trp Asp Arg Ala Leu Ile Gln Leu Gln Val
         435                 440                 445            
 Arg Ala Leu Leu Ser Ser Thr Gly Ser Gln Ala Val Ala Met Asp Leu
     450                 455                 460                
 Gly Asn Arg Lys Leu Glu Ile Ser Ser Gly Lys Leu Ala Arg Phe Ala
 465                 470                 475                 480
 Asn Gly Ser Ala Val Ile Gln Ser Gly Asp Thr Ala Val Met Ala Thr
                 485                 490                 495    
 Ala Val Ser Lys Thr Lys Pro Ser Pro Ser Gln Phe Met Pro Leu Val
             500                 505                 510        
 Val Asp Tyr Arg Gln Lys Ala Ala Ala Val Gly Met Thr Asp Gly Glu
         515                 520                 525            
 Cys Val Val Asn Pro Thr Arg Lys Glu Met Ser Ser Ser Thr Leu Asn
     530                 535                 540                
 Val Val Val Ala Gly Ala Pro Lys Ser Gln Thr Val Met Leu Glu Ala
 545                 550                 555                 560
 Ser Ala Glu Asn Ile Leu Gln Gln Asp Phe Cys His Ala Ile Lys Val
                 565                 570                 575    
 Gly Val Lys Tyr Thr Gln Gln Ile Ile Gln Gly Ile Gln Gln Leu Val
             580                 585                 590        
 Lys Glu Ile Gly Val Thr Lys Arg Thr Pro Gln Lys Leu Phe Thr Pro
         595                 600                 605            
 Ser Gln Glu Ile Val Lys His Ala His Lys Leu Thr Met Glu Arg Leu
     610                 615                 620                
 Tyr Ala Val Phe Thr Asp Tyr Glu His Asp Lys Ile Ser Arg Asp Glu
 625                 630                 635                 640
 Ala Val Asn Lys Ile Arg Leu Asp Thr Glu Glu Gln Leu Lys Glu Ile
                 645                 650                 655    
 Phe Pro Glu Val Asp Leu Tyr Glu Ile Ile Glu Ser Phe Asn Thr Val
             660                 665                 670        
 Ala Lys Glu Val Phe Arg Ser Ile Ile Leu Asn Glu Tyr Lys Arg Cys
         675                 680                 685            
 Asp Gly Arg Asp Leu Thr Leu Leu Arg Asn Ile Ser Cys Glu Val Asp
     690                 695                 700                
 Met Phe Lys Thr Leu His Gly Ser Glu Leu Phe Gln Arg Gly Gln Thr
 705                 710                 715                 720
 Gln Leu Leu Cys Ala Val Thr Phe Asp Ser Leu Glu Ser Ser Ile Lys
                 725                 730                 735    
 Leu Asp Arg Val Ile Thr Thr Ile Asn Gly Ile Lys Asp Lys Asn Phe
             740                 745                 750        
 Met Leu His Tyr Glu Phe Pro Pro Tyr Ala Thr Asn Glu Ile Val Lys
         755                 760                 765            
 Val Thr Gly Ile Asn Arg Arg Glu Leu Gly Pro Gly Ala Leu Ala Glu
     770                 775                 780                
 Lys Ala Leu Tyr Pro Val Ile Pro Lys Asp Phe Pro Phe Ala Ile Arg
 785                 790                 795                 800
 Val Thr Ser Glu Val Leu Glu Ser Asn Gly Ser Ser Ser Met Ala Ser
                 805                 810                 815    
 Ala Cys Gly Val Ala Met Gly Leu Ala Thr Lys Thr Asp Leu Glu Lys
             820                 825                 830        
 Gly Glu Ile Glu Asp Tyr His Leu Leu Thr Asp Ile Leu Gly Ile Glu
         835                 840                 845            
 Ala Tyr Asn Gly Asp Met Asp Phe Lys Ile Ala Gly Thr Asn Lys Gly
     850                 855                 860                
 Ile Thr Ala Leu Gln Ala Asp Ile Lys Leu Pro Gly Ile Thr Met Lys
 865                 870                 875                 880
 Ile Val Met Glu Ala Ile Gln Gln Ala Ser Val Ala Lys Arg Arg Phe
                 885                 890                 895    
 Tyr Arg Ser
            



      <210> 2542
      <211> 117
      <212> PRT
      <213> Homo sapiens


      <400> 2542
 His Thr Gly Glu Lys Pro Tyr Glu Cys Gly Gln Cys Gly Arg Ala Phe
   1               5                  10                  15    
 Ser His Ser Ser His Phe Thr Gln His Leu Arg Ile His Asn Gly Glu
              20                  25                  30        
 Lys Pro Tyr Lys Cys Gly Glu Cys Gly Gln Ala Phe Ser Gln Ser Ser
          35                  40                  45            
 Asn Leu Val Arg His Gln Arg Leu His Thr Gly Glu Lys Pro Tyr Ala
      50                  55                  60                
 Cys Ser Gln Cys Gly Lys Ala Phe Ile Trp Ser Ser Val Leu Ile Glu
  65                  70                  75                  80
 His Gln Arg Ile His Thr Gly Glu Lys Pro Tyr Glu Cys Ser Asp Cys
                  85                  90                  95    
 Gly Lys Ala Phe Arg Gly Arg Ser His Phe Phe Arg His Leu Arg Thr
             100                 105                 110        
 His Thr Gly Glu Lys
         115        



      <210> 2543
      <211> 131
      <212> PRT
      <213> Homo sapiens

      <220>
      <221> misc_feature
      <222> (1)...(131)
      <223> Xaa = any amino acid or symbol as shown in the table 8 as set forth in Example 2


      <400> 2543
 Phe Ile Tyr His Ser Asp Tyr Ile Leu His Gln Arg Ile His Thr Gly
   1               5                  10                  15    
 Glu Lys Pro His Arg Cys Cys Asp Cys Gly Lys Ala Phe Ser Asn Ser
              20                  25                  30        
 Ser Tyr Phe Ile Gln His His Ile Ile Gln Thr Gly Glu Lys Pro Tyr
          35                  40                  45            
 Ala Cys Arg Ala Cys Gly Lys Thr Phe Thr Gln Ser Ser Ser Leu Thr
      50                  55                  60                
 Xaa His Gln Arg Ile His Thr Gly Glu Lys Pro Tyr Lys Cys Lys Asp
  65                  70                  75                  80
 Cys Gly Lys Ala Phe Thr Gln Ser Ser Ser Leu Ile Lys His Gln Arg
                  85                  90                  95    
 Cys His Thr Gly Glu Lys Pro Tyr Lys Cys Gly Gln Cys Gly Lys Phe
             100                 105                 110        
 Phe Ser Gln Val Ser His Leu Thr Arg His Gln Lys Ile His Thr Gly
         115                 120                 125            
 Ala Arg Ala
     130    



      <210> 2544
      <211> 193
      <212> PRT
      <213> Homo sapiens


      <400> 2544
 Pro Ser Ser Leu Asn Leu Lys Val Ile Ala Met Asp Leu Ala Gln Met
   1               5                  10                  15    
 His Ala Cys Gln Gly Pro Gly Asn Asp Leu Tyr Ile Glu Ala Ser Ala
              20                  25                  30        
 Ala Leu Cys Ala Gly Ser Asp Phe Ser Val Ser Gly Gly Leu Gln Trp
          35                  40                  45            
 Val Gln Leu Val Ala His Gly Ser Ala Gly Asp Asp Asn Gly Trp Leu
      50                  55                  60                
 Arg Cys His Arg Pro Pro Trp Gln Gly Leu Gly Asp Asn Glu Leu Asp
  65                  70                  75                  80
 Gly Cys Ser Gly Glu Val Asn Val Ser Gln Asp Phe Cys Gly Lys Tyr
                  85                  90                  95    
 Thr Asp Val Val Asn His Ile Thr Gln Arg Leu Asp Tyr Val Leu Cys
             100                 105                 110        
 Arg Thr Tyr Ala Ala Gln Arg Thr Cys His Ser Gly Ser Val Val Lys
         115                 120                 125            
 Glu Val Lys Phe Ile His Asp Gln Thr Ser Pro Asn Pro Lys Tyr Arg
     130                 135                 140                
 Gly Phe Phe His Gly Val Arg Glu Ile Val Arg Glu Gln Gly Leu Lys
 145                 150                 155                 160
 Gly Thr Phe His Gly Leu Thr Ala Thr Val Pro Glu Thr Gly Leu Arg
                 165                 170                 175    
 Thr Gln Ala Ile Pro Phe Phe Val Met Asn Ser Leu Arg Asn Trp Phe
             180                 185                 190        
 Arg
    



      <210> 2545
      <211> 311
      <212> PRT
      <213> Homo sapiens


      <400> 2545
 Ala Ile Val Pro Ser Trp Asp Leu Asp Lys Asn Thr Ile Ser Leu Leu
   1               5                  10                  15    
 Ser Pro Val Leu Cys Ile Phe Pro Ser Pro Ser Ser Gln Thr Ser Leu
              20                  25                  30        
 Leu Tyr Val Phe Ser Leu Ala Gly Arg Met Thr Gln Asn Thr Val Ile
          35                  40                  45            
 Val Asn Gly Val Ala Met Ala Ser Arg Pro Ser Gln Pro Thr His Val
      50                  55                  60                
 Asn Val His Ile His Gln Glu Ser Ala Leu Thr Gln Leu Leu Lys Ala
  65                  70                  75                  80
 Gly Gly Ser Leu Lys Lys Phe Leu Phe His Pro Gly Asp Thr Val Pro
                  85                  90                  95    
 Ser Thr Ala Arg Ile Gly Tyr Glu Gln Leu Ala Leu Gly Val Thr Gln
             100                 105                 110        
 Ile Leu Leu Gly Val Val Ser Cys Val Leu Gly Val Cys Leu Ser Leu
         115                 120                 125            
 Gly Pro Trp Thr Val Leu Ser Ala Ser Gly Cys Ala Phe Trp Ala Gly
     130                 135                 140                
 Ser Val Val Ile Ala Ala Gly Ala Gly Ala Ile Val His Glu Lys His
 145                 150                 155                 160
 Pro Gly Lys Leu Ala Gly Tyr Ile Ser Ser Leu Leu Thr Leu Ala Gly
                 165                 170                 175    
 Phe Ala Thr Ala Met Ala Ala Val Val Leu Cys Val Asn Ser Phe Ile
             180                 185                 190        
 Trp Gln Thr Glu Pro Phe Leu Tyr Ile Asp Thr Val Cys Asp Arg Ser
         195                 200                 205            
 Asp Pro Val Phe Pro Thr Thr Gly Tyr Arg Trp Met Arg Arg Ser Gln
     210                 215                 220                
 Glu Asn Gln Trp Gln Lys Glu Glu Cys Arg Ala Tyr Met Gln Met Leu
 225                 230                 235                 240
 Arg Lys Leu Phe Thr Ala Ile Arg Ala Leu Phe Leu Ala Val Cys Val
                 245                 250                 255    
 Leu Lys Val Ile Val Ser Leu Val Ser Leu Gly Val Gly Leu Arg Asn
             260                 265                 270        
 Leu Cys Gly Gln Ser Ser Gln Pro Leu Asn Glu Glu Gly Ser Glu Lys
         275                 280                 285            
 Arg Leu Leu Gly Glu Asn Ser Val Pro Pro Ser Pro Ser Arg Glu Gln
     290                 295                 300                
 Thr Ser Thr Ala Ile Val Leu
 305                 310    



      <210> 2546
      <211> 595
      <212> PRT
      <213> Homo sapiens


      <400> 2546
 Gly Pro Gly Ala Glu Ala Ala Thr Arg Asp Ala Ala Arg Thr Leu Arg
   1               5                  10                  15    
 Pro Ala Gln Pro Gly Pro Ala Met Ala Ala Pro Arg Pro Ser Pro Ala
              20                  25                  30        
 Ile Ser Val Ser Val Ser Ala Pro Ala Phe Tyr Ala Pro Gln Lys Lys
          35                  40                  45            
 Phe Gly Pro Val Val Ala Pro Lys Pro Lys Val Asn Pro Phe Arg Pro
      50                  55                  60                
 Gly Asp Ser Glu Pro Pro Pro Ala Pro Gly Ala Gln Arg Ala Gln Met
  65                  70                  75                  80
 Gly Arg Val Gly Glu Ile Pro Pro Pro Pro Pro Glu Asp Phe Pro Leu
                  85                  90                  95    
 Pro Pro Pro Pro Leu Ala Gly Asp Gly Asp Asp Ala Glu Gly Ala Leu
             100                 105                 110        
 Gly Gly Ala Phe Pro Pro Pro Pro Pro Pro Ile Glu Glu Ser Phe Leu
         115                 120                 125            
 Pro Ala Pro Leu Glu Glu Glu Ile Phe Pro Ser Pro Pro Pro Pro Pro
     130                 135                 140                
 Glu Glu Glu Gly Gly Pro Glu Ala Pro Ile Pro Pro Pro Pro Gln Pro
 145                 150                 155                 160
 Arg Glu Lys Val Ser Ser Ile Asp Leu Glu Ile Asp Ser Leu Ser Ser
                 165                 170                 175    
 Leu Leu Asp Asp Met Thr Lys Asn Asp Pro Phe Lys Ala Arg Val Ser
             180                 185                 190        
 Ser Gly Tyr Val Pro Pro Pro Val Ala Thr Pro Phe Ser Ser Lys Ser
         195                 200                 205            
 Ser Thr Lys Pro Ala Ala Gly Gly Thr Ala Pro Leu Pro Pro Trp Lys
     210                 215                 220                
 Ser Pro Ser Ser Ser Gln Pro Leu Pro Gln Val Pro Ala Pro Ala Gln
 225                 230                 235                 240
 Ser Gln Thr Gln Phe His Val Gln Pro Gln Pro Gln Pro Lys Pro Gln
                 245                 250                 255    
 Val Gln Leu His Val Gln Ser Gln Thr Gln Pro Val Ser Leu Ala Asn
             260                 265                 270        
 Thr Gln Pro Arg Gly Pro Pro Ala Ser Ser Pro Ala Pro Ala Pro Lys
         275                 280                 285            
 Phe Ser Pro Val Thr Pro Lys Phe Thr Pro Val Ala Ser Lys Phe Ser
     290                 295                 300                
 Pro Gly Ala Pro Gly Gly Ser Gly Ser Gln Pro Asn Gln Lys Leu Gly
 305                 310                 315                 320
 His Pro Glu Ala Leu Ser Ala Gly Thr Gly Ser Pro Gln Pro Pro Ser
                 325                 330                 335    
 Phe Thr Tyr Ala Gln Gln Arg Glu Lys Pro Arg Val Gln Glu Lys Gln
             340                 345                 350        
 His Pro Val Pro Pro Pro Ala Gln Asn Gln Asn Gln Val Arg Ser Pro
         355                 360                 365            
 Gly Ala Pro Gly Pro Leu Thr Leu Lys Glu Val Glu Glu Leu Glu Gln
     370                 375                 380                
 Leu Thr Gln Gln Leu Met Gln Asp Met Glu His Pro Gln Arg Gln Asn
 385                 390                 395                 400
 Val Ala Val Asn Glu Leu Cys Gly Arg Cys His Gln Pro Leu Ala Arg
                 405                 410                 415    
 Ala Gln Pro Ala Val Arg Ala Leu Gly Gln Leu Phe His Ile Ala Cys
             420                 425                 430        
 Phe Thr Cys His Gln Cys Ala Gln Gln Leu Gln Gly Gln Gln Phe Tyr
         435                 440                 445            
 Ser Leu Glu Gly Ala Pro Tyr Cys Glu Gly Cys Tyr Thr Asp Thr Leu
     450                 455                 460                
 Glu Lys Cys Asn Thr Cys Gly Glu Pro Ile Thr Asp Arg Met Leu Arg
 465                 470                 475                 480
 Ala Thr Gly Lys Ala Tyr His Pro His Cys Phe Thr Cys Val Val Cys
                 485                 490                 495    
 Ala Arg Pro Leu Glu Gly Thr Ser Phe Ile Val Asp Gln Ala Asn Arg
             500                 505                 510        
 Pro His Cys Val Pro Asp Tyr His Lys Gln Tyr Ala Pro Arg Cys Ser
         515                 520                 525            
 Val Cys Ser Glu Pro Ile Met Pro Glu Pro Gly Arg Asp Glu Thr Val
     530                 535                 540                
 Arg Val Val Ala Leu Asp Lys Asn Phe His Met Lys Cys Tyr Lys Cys
 545                 550                 555                 560
 Glu Asp Cys Gly Lys Pro Leu Ser Ile Glu Ala Asp Asp Asn Gly Cys
                 565                 570                 575    
 Phe Pro Leu Asp Gly His Val Leu Cys Arg Lys Cys His Thr Ala Arg
             580                 585                 590        
 Ala Gln Thr
         595



      <210> 2547
      <211> 175
      <212> PRT
      <213> Homo sapiens


      <400> 2547
 Ala Trp Arg Ala Gly Gly Arg Arg Arg Val Gly Gln Gly Asn Ser Gly
   1               5                  10                  15    
 Leu Gln Ser Pro Cys Trp Gly Phe Gly Glu Arg Leu Asp Pro Gly Phe
              20                  25                  30        
 Trp Asp Ala Ser Gly Glu Gly Ser Thr Gly Phe Ala Phe Ile Arg Pro
          35                  40                  45            
 Lys Met Pro Phe Phe Gly Asn Thr Phe Ser Pro Lys Lys Thr Pro Pro
      50                  55                  60                
 Arg Lys Ser Ala Ser Leu Ser Asn Leu His Ser Leu Asp Arg Ser Thr
  65                  70                  75                  80
 Arg Glu Val Glu Leu Gly Leu Glu Tyr Gly Ser Pro Thr Met Asn Leu
                  85                  90                  95    
 Ala Gly Gln Ser Leu Lys Phe Glu Asn Gly Gln Trp Ile Ala Glu Thr
             100                 105                 110        
 Gly Val Ser Gly Gly Val Asp Arg Arg Glu Val Gln Arg Leu Arg Arg
         115                 120                 125            
 Arg Asn Gln Gln Leu Glu Glu Glu Asn Asn Leu Leu Arg Leu Lys Val
     130                 135                 140                
 Asp Ile Leu Leu Asp Met Leu Ser Glu Ser Thr Ala Glu Ser His Leu
 145                 150                 155                 160
 Met Glu Lys Glu Leu Asp Glu Leu Arg Ile Ser Arg Lys Arg Lys
                 165                 170                 175



      <210> 2548
      <211> 146
      <212> PRT
      <213> Homo sapiens


      <400> 2548
 Gly Pro Leu Val Val Asp Thr Gly Gly His Arg Gly Tyr Val Pro Ala
   1               5                  10                  15    
 Gly Lys Leu Gln Leu Tyr His Val Val Pro Ser Ala Glu Glu Leu Arg
              20                  25                  30        
 Arg Gln Ala Gly Leu Asn Lys Asp Pro Arg Cys Leu Thr Pro Glu Pro
          35                  40                  45            
 Ser Pro Ala Leu Val Pro Ser Ile Pro Thr Gly Asn Gln Val Ile Ala
      50                  55                  60                
 Ala Tyr Pro Phe Val Ala Arg Ser Ser His Glu Val Ser Leu Gln Ala
  65                  70                  75                  80
 Gly Gln Pro Val Thr Ile Leu Glu Ala Gln Asp Lys Lys Gly Asn Pro
                  85                  90                  95    
 Glu Trp Ser Leu Val Glu Val Asn Gly Gln Arg Gly Tyr Val Pro Ser
             100                 105                 110        
 Gly Phe Leu Ala Arg Gly Ser Glu Pro Ser Ser Val Gly Leu Glu Ser
         115                 120                 125            
 Ala Leu Leu Gly Tyr Pro Leu Trp Ser Leu His Cys Gln Met Met Gly
     130                 135                 140                
 Glu Ala
 145    



      <210> 2549
      <211> 314
      <212> PRT
      <213> Homo sapiens


      <400> 2549
 Gly Pro Arg Cys Trp Lys Phe Leu Ile Leu Ser Ser Val Asn Cys Glu
   1               5                  10                  15    
 Thr Leu Arg Ile Gly Lys Ala Trp Pro Gln Ser Ser Gly Gln Glu Arg
              20                  25                  30        
 Tyr Trp Thr Pro Arg Thr His Ser Ser Ala Ser Glu Ala Gln Arg Gly
          35                  40                  45            
 Ser Leu Ala Glu Leu Asn Val Ala Ala Ala Gly Leu Trp Ala Asp Cys
      50                  55                  60                
 Asp Gln Pro Leu Tyr Asp Cys Pro Met Cys Gly Leu Ile Cys Thr Asn
  65                  70                  75                  80
 Tyr His Ile Leu Gln Glu His Val Asp Leu His Leu Glu Glu Asn Ser
                  85                  90                  95    
 Phe Gln Gln Gly Met Asp Arg Val Gln Cys Ser Gly Asp Leu Gln Leu
             100                 105                 110        
 Ala His Gln Leu Gln Gln Glu Glu Asp Arg Lys Arg Arg Ser Glu Glu
         115                 120                 125            
 Ser Arg Gln Glu Ile Glu Glu Phe Gln Lys Leu Gln Arg Gln Tyr Gly
     130                 135                 140                
 Leu Asp Asn Ser Gly Gly Tyr Lys Gln Gln Gln Leu Arg Asn Met Glu
 145                 150                 155                 160
 Ile Glu Val Asn Arg Gly Arg Met Pro Pro Ser Glu Phe His Arg Arg
                 165                 170                 175    
 Lys Ala Asp Met Met Glu Ser Leu Ala Leu Gly Phe Asp Asp Gly Lys
             180                 185                 190        
 Thr Lys Thr Ser Gly Ile Ile Glu Ala Leu His Arg Tyr Tyr Gln Asn
         195                 200                 205            
 Ala Ala Thr Asp Val Arg Arg Val Trp Leu Ser Ser Val Val Asp His
     210                 215                 220                
 Phe His Ser Ser Leu Gly Asp Lys Gly Trp Gly Cys Gly Tyr Arg Asn
 225                 230                 235                 240
 Phe Gln Met Leu Leu Ser Ser Leu Leu Gln Asn Asp Ala Tyr Asn Asp
                 245                 250                 255    
 Cys Leu Lys Gly Met Leu Ile Pro Cys Ile Pro Lys Ile Gln Ser Met
             260                 265                 270        
 Ile Glu Asp Ala Trp Lys Glu Gly Phe Asp Pro Gln Gly Ala Ser Gln
         275                 280                 285            
 Leu Ile Ile Arg Leu Gln Gly Thr Lys Ala Trp Ile Gly Ala Cys Glu
     290                 295                 300                
 Val Tyr Ile Leu Leu Thr Ser Leu Arg Val
 305                 310                



      <210> 2550
      <211> 116
      <212> PRT
      <213> Homo sapiens


      <400> 2550
 Gly Cys Val Gly Val Arg Pro Ser Leu His Pro Ala Thr Ser Thr Ala
   1               5                  10                  15    
 Ser Gly Ser Ala Ser Pro Thr Leu Ala Arg Ala Met Ala Ser Val Ser
              20                  25                  30        
 Glu Leu Ala Cys Ile Tyr Ser Ala Leu Ile Leu His Asp Asp Glu Val
          35                  40                  45            
 Thr Val Thr Ala Leu Ala Asn Val Asn Ile Gly Ser Leu Ile Cys Asn
      50                  55                  60                
 Val Gly Ala Gly Gly Pro Ala Pro Ala Ala Gly Ala Ala Pro Ala Gly
  65                  70                  75                  80
 Gly Pro Ala Pro Ser Thr Ala Ala Ala Pro Ala Glu Glu Lys Lys Val
                  85                  90                  95    
 Glu Ala Lys Lys Glu Glu Ser Glu Glu Ser Asp Asp Asp Met Gly Phe
             100                 105                 110        
 Gly Leu Phe Asp
         115    



      <210> 2551
      <211> 252
      <212> PRT
      <213> Homo sapiens


      <400> 2551
 Gly Leu Thr Ala Ser Thr His Ala Ser Ala Asp Ala Trp Ala Ala Met
   1               5                  10                  15    
 Ala Ala Ala Ser Gly Ser Val Leu Gln Arg Cys Ile Val Ser Pro Ala
              20                  25                  30        
 Gly Arg His Ser Ala Ser Leu Ile Phe Leu His Gly Ser Gly Asp Ser
          35                  40                  45            
 Gly Gln Gly Leu Arg Met Trp Ile Lys Gln Val Leu Asn Gln Asp Leu
      50                  55                  60                
 Thr Phe Gln His Ile Lys Ile Ile Tyr Pro Thr Ala Pro Pro Arg Ser
  65                  70                  75                  80
 Tyr Thr Pro Met Lys Gly Gly Ile Ser Asn Val Trp Phe Asp Arg Phe
                  85                  90                  95    
 Lys Ile Thr Asn Asp Cys Pro Glu His Leu Glu Ser Ile Asp Val Met
             100                 105                 110        
 Cys Gln Val Leu Thr Asp Leu Ile Asp Glu Glu Val Lys Ser Gly Ile
         115                 120                 125            
 Lys Lys Asn Arg Ile Leu Ile Gly Gly Phe Ser Met Gly Gly Cys Met
     130                 135                 140                
 Ala Met His Leu Ala Tyr Arg Asn His Gln Asp Val Ala Gly Val Phe
 145                 150                 155                 160
 Ala Leu Ser Ser Phe Leu Asn Lys Ala Ser Ala Val Tyr Gln Ala Leu
                 165                 170                 175    
 Gln Lys Ser Asn Gly Val Leu Pro Glu Leu Phe Gln Cys His Gly Thr
             180                 185                 190        
 Ala Asp Glu Leu Val Leu His Ser Trp Ala Glu Glu Thr Asn Ser Met
         195                 200                 205            
 Leu Lys Ser Leu Gly Val Thr Thr Lys Phe His Ser Phe Pro Asn Val
     210                 215                 220                
 Tyr His Glu Leu Ser Lys Thr Glu Leu Asp Ile Leu Lys Leu Trp Ile
 225                 230                 235                 240
 Leu Thr Lys Leu Pro Gly Glu Met Glu Lys Gln Lys
                 245                 250        



      <210> 2552
      <211> 199
      <212> PRT
      <213> Homo sapiens


      <400> 2552
 Phe Arg Val Asp Trp Gly Arg Ile Met Ala Gly Ala Ala Glu Asp Ala
   1               5                  10                  15    
 Arg Ala Leu Phe Arg Ala Gly Val Cys Ala Ala Leu Glu Ala Trp Pro
              20                  25                  30        
 Ala Leu Gln Ile Ala Val Glu Asn Gly Phe Gly Gly Val His Ser Gln
          35                  40                  45            
 Glu Lys Ala Lys Trp Leu Gly Gly Ala Val Glu Asp Tyr Phe Met Arg
      50                  55                  60                
 Asn Ala Asp Leu Glu Leu Asp Glu Val Glu Asp Phe Leu Gly Glu Leu
  65                  70                  75                  80
 Leu Thr Asn Glu Phe Asp Thr Val Val Glu Asp Gly Ser Leu Pro Gln
                  85                  90                  95    
 Val Ser Gln Gln Leu Gln Thr Met Phe His His Phe Gln Arg Gly Asp
             100                 105                 110        
 Gly Ala Ala Leu Arg Glu Met Ala Ser Cys Ile Thr Gln Arg Lys Cys
         115                 120                 125            
 Lys Val Thr Ala Thr Ala Leu Lys Thr Ala Arg Glu Thr Asp Glu Asp
     130                 135                 140                
 Glu Asp Asp Val Asp Ser Val Glu Glu Met Glu Val Thr Ala Thr Asn
 145                 150                 155                 160
 Asp Gly Ala Ala Thr Asp Gly Val Cys Pro Gln Pro Glu Pro Ser Asp
                 165                 170                 175    
 Pro Asp Ala Gln Thr Ile Lys Glu Glu Asp Ile Val Glu Asp Gly Trp
             180                 185                 190        
 Thr Ile Val Arg Arg Lys Lys
         195                



      <210> 2553
      <211> 62
      <212> PRT
      <213> Homo sapiens


      <400> 2553
 Phe Ser Val Phe Pro Val Ser Pro Pro Pro Phe Gln Glu Arg Thr Thr
   1               5                  10                  15    
 Pro Val His His Glu Gly Gln Gly Ser Lys Ser Ser Gln Met Cys Pro
              20                  25                  30        
 Gly Arg Tyr Leu Arg Asn Glu Tyr Ala Asp Ser Gly Arg Gly Val Glu
          35                  40                  45            
 Lys Val Ile Leu Tyr Pro His Pro Gly Lys Pro Ala Leu Cys
      50                  55                  60        



      <210> 2554
      <211> 152
      <212> PRT
      <213> Homo sapiens

      <220>
      <221> misc_feature
      <222> (1)...(152)
      <223> Xaa = any amino acid or symbol as shown in the table 8 as set forth in Example 2


      <400> 2554
 Trp Ala Gly Ala Gly Gly Ala Gly Arg Arg His Val Arg Ser Glu Leu
   1               5                  10                  15    
 Ala Pro Gly Gln Arg Arg Ser Phe Pro Pro Arg Gly Trp Ala Ala Asp
              20                  25                  30        
 His Ala Thr Val Gly Gly Gly Xaa Gly Lys Gly Thr Ser Asn Pro Pro
          35                  40                  45            
 Gln Pro His Ala Pro Leu Ser Pro Asn Pro Pro Thr Val Leu Gly Pro
      50                  55                  60                
 Gln Leu Pro Pro Arg Trp Ala Xaa Val Ser Leu Leu Cys Val Leu Ser
  65                  70                  75                  80
 Ser Pro Pro Val Leu Pro Ala Gly Gly Lys Gly Ala Pro Ser Val Gln
                  85                  90                  95    
 Pro Leu Lys Pro Arg Gly Glu Pro Leu Leu Ala Ala Thr Gln Arg Asn
             100                 105                 110        
 Pro Pro Val Pro Arg Arg Gly Pro Ser Ala Thr Gly Pro Gly Ala Leu
         115                 120                 125            
 Pro Arg Phe Gln Gln Pro Arg Arg Pro Asp Ser Asp Pro Gly Met Trp
     130                 135                 140                
 Gly Pro Arg Pro Asp Ala Trp Val
 145                 150        



      <210> 2555
      <211> 306
      <212> PRT
      <213> Homo sapiens

      <220>
      <221> misc_feature
      <222> (1)...(306)
      <223> Xaa = any amino acid or symbol as shown in the table 8 as set forth in Example 2


      <400> 2555
 Tyr Arg Asp Val Met Leu Glu Asn Tyr Lys Asn Leu Val Ala Val Asp
   1               5                  10                  15    
 Trp Glu Ser His Ile Asn Thr Lys Trp Ser Ala Pro Gln Gln Asn Phe
              20                  25                  30        
 Leu Gln Gly Lys Thr Ser Ser Val Val Glu Met Asn Ser Glu Xaa Lys
          35                  40                  45            
 Gly Glu Ser Gln Xaa Asn Lys Phe Gly Lys Leu Leu Xaa Thr Ile Ile
      50                  55                  60                
 Asn Phe His Gln Gln Glu Arg Asn His Phe Gly Glu Glu Leu Phe Asp
  65                  70                  75                  80
 Phe Asn Gln Cys Glu Lys Ala Leu Ser Glu His Ser Cys Leu Lys Thr
                  85                  90                  95    
 His Arg Arg Thr Tyr Phe Arg Lys Lys Thr Cys Glu Cys Asn Gln Cys
             100                 105                 110        
 Glu Lys Ala Phe Arg Lys Pro Ser Ile Phe Thr Leu His Lys Lys Thr
         115                 120                 125            
 Asp Ile Gly Glu Glu Leu Pro Asn Cys Asn Gln Cys Glu Thr Ala Phe
     130                 135                 140                
 Ser Gln His Leu His Leu Val Cys Lys Lys Thr Ser Gln Asn Leu His
 145                 150                 155                 160
 Leu Val Cys Lys Lys Thr His Thr Gln Glu Lys Pro Tyr Lys Cys Ser
                 165                 170                 175    
 Asp Cys Glu Lys Gly Leu Pro Ser Ser Ser His Leu Arg Glu Cys Val
             180                 185                 190        
 Arg Ile Tyr Gly Gly Glu Arg Pro Tyr Thr His Lys Glu Tyr Val Glu
         195                 200                 205            
 Thr Phe Ser His Ser Thr Ala Leu Phe Val His Met Gln Thr Gln Asp
     210                 215                 220                
 Gly Glu Lys Phe Tyr Glu Cys Lys Ala Cys Gly Lys Pro Phe Thr Glu
 225                 230                 235                 240
 Ser Ser Tyr Leu Thr Gln His Leu Arg Thr His Ser Arg Val Leu Pro
                 245                 250                 255    
 Ile Glu His Lys Lys Phe Gly Lys Ala Phe Ala Phe Ser Pro Asp Leu
             260                 265                 270        
 Ala Lys His Ile Lys Leu Lys Thr Arg Gly Lys His Tyr Val Cys Asn
         275                 280                 285            
 Glu Cys Gly Lys Glu Phe Thr Cys Phe Ser Lys Leu Asn Ile His Ile
     290                 295                 300                
 Arg Gly
 305    



      <210> 2556
      <211> 1030
      <212> PRT
      <213> Homo sapiens


      <400> 2556
 Ala Gly Thr Val Ile Ser Val Cys Gln Ala Leu Ile Ala Glu Glu Thr
   1               5                  10                  15    
 Ser Ser Arg Leu Ala Glu Gln Glu Glu Glu Pro Glu Lys Phe Arg Glu
              20                  25                  30        
 Ala Leu Val Lys Phe Glu Ala Arg Phe Asn Phe Pro Glu Ala Glu Lys
          35                  40                  45            
 Leu Val Thr Tyr Tyr Ser Cys Cys Cys Trp Lys Gly Arg Val Pro Arg
      50                  55                  60                
 Gln Gly Trp Leu Tyr Leu Ser Ile Asn His Leu Cys Phe Tyr Ser Phe
  65                  70                  75                  80
 Phe Leu Gly Lys Glu Leu Lys Leu Val Val Pro Trp Val Asp Ile Gln
                  85                  90                  95    
 Lys Leu Glu Arg Thr Ser Asn Val Phe Leu Thr Asp Thr Ile Arg Ile
             100                 105                 110        
 Thr Thr Gln Asn Lys Glu Arg Asp Phe Ser Met Phe Leu Asn Leu Asp
         115                 120                 125            
 Glu Val Phe Lys Val Met Glu Gln Leu Ala Asp Val Thr Leu Arg Arg
     130                 135                 140                
 Leu Leu Asp Asn Glu Val Phe Asp Leu Asp Pro Asp Leu Gln Glu Pro
 145                 150                 155                 160
 Ser Gln Ile Thr Lys Arg Asp Leu Glu Ala Arg Ala Gln Asn Glu Phe
                 165                 170                 175    
 Phe Arg Ala Phe Phe Arg Leu Pro Arg Lys Glu Lys Leu His Ala Val
             180                 185                 190        
 Val Asp Cys Ser Leu Trp Thr Pro Phe Ser Arg Cys His Thr Ala Gly
         195                 200                 205            
 Arg Met Phe Ala Ser Asp Ser Tyr Ile Cys Phe Ala Ser Arg Glu Asp
     210                 215                 220                
 Gly Cys Cys Lys Ile Ile Leu Pro Leu Arg Glu Val Val Ser Ile Glu
 225                 230                 235                 240
 Lys Met Glu Asp Thr Ser Leu Leu Pro His Pro Ile Ile Val Ser Ile
                 245                 250                 255    
 Arg Ser Lys Val Ala Phe Gln Phe Ile Glu Leu Arg Asp Arg Asp Ser
             260                 265                 270        
 Leu Val Glu Ala Leu Leu Ala Arg Leu Lys Gln Val His Ala Asn His
         275                 280                 285            
 Pro Val His Tyr Asp Thr Ser Ala Asp Asp Asp Met Ala Ser Leu Val
     290                 295                 300                
 Phe His Ser Thr Ser Met Cys Ser Asp His Arg Phe Gly Asp Pro Glu
 305                 310                 315                 320
 Ile Met Ser Ser Gln Asn Ser Glu Glu Ser Glu Lys Glu Lys Ser Pro
                 325                 330                 335    
 Leu Met His Pro Asp Ala Leu Val Thr Ala Phe Gln Gln Ser Gly Ser
             340                 345                 350        
 Gln Ser Pro Asp Ser Arg Met Ser Arg Glu Gln Ile Lys Ile Ser Leu
         355                 360                 365            
 Trp Asn Asp His Phe Val Glu Tyr Gly Arg Thr Val Cys Met Phe Arg
     370                 375                 380                
 Thr Glu Lys Ile Arg Lys Leu Val Ala Met Gly Ile Pro Glu Ser Leu
 385                 390                 395                 400
 Arg Gly Arg Leu Trp Leu Leu Phe Ser Asp Ala Val Thr Asp Leu Ala
                 405                 410                 415    
 Ser His Pro Gly Tyr Tyr Gly Asn Leu Val Glu Glu Ser Leu Gly Lys
             420                 425                 430        
 Cys Cys Leu Val Thr Glu Glu Ile Glu Arg Asp Leu His Arg Ser Leu
         435                 440                 445            
 Pro Glu His Pro Ala Phe Gln Asn Glu Thr Gly Ile Ala Ala Leu Arg
     450                 455                 460                
 Arg Val Leu Thr Ala Tyr Ala His Arg Asn Pro Lys Ile Gly Tyr Cys
 465                 470                 475                 480
 Gln Ser Met Asn Ile Leu Thr Ser Val Leu Leu Leu Tyr Thr Lys Glu
                 485                 490                 495    
 Glu Glu Ala Phe Trp Leu Leu Val Ala Val Cys Glu Arg Met Leu Pro
             500                 505                 510        
 Asp Tyr Phe Asn His Arg Val Ile Gly Ala Gln Val Asp Gln Ser Val
         515                 520                 525            
 Phe Glu Glu Leu Ile Lys Gly His Leu Pro Glu Leu Ala Glu His Met
     530                 535                 540                
 Asn Asp Leu Ser Ala Leu Ala Ser Val Ser Leu Ser Trp Phe Leu Thr
 545                 550                 555                 560
 Leu Phe Leu Ser Ile Met Pro Leu Glu Ser Ala Val Asn Val Val Asp
                 565                 570                 575    
 Cys Phe Phe Tyr Asp Gly Ile Lys Ala Ile Phe Gln Leu Gly Leu Ala
             580                 585                 590        
 Val Leu Glu Ala Asn Ala Glu Asp Leu Cys Ser Ser Lys Asp Asp Gly
         595                 600                 605            
 Gln Ala Leu Met Ile Leu Ser Arg Phe Leu Asp His Ile Lys Asn Glu
     610                 615                 620                
 Asp Ser Pro Gly Pro Pro Val Gly Ser His His Ala Phe Phe Ser Asp
 625                 630                 635                 640
 Asp Gln Glu Pro Tyr Pro Val Thr Asp Ile Ser Asp Leu Ile Arg Asp
                 645                 650                 655    
 Ser Tyr Glu Lys Phe Gly Asp Gln Ser Val Glu Gln Ile Glu His Leu
             660                 665                 670        
 Arg Tyr Lys His Arg Ile Arg Val Leu Gln Gly His Glu Asp Thr Thr
         675                 680                 685            
 Lys Gln Asn Val Leu Arg Val Val Ile Pro Glu Val Ser Ile Leu Pro
     690                 695                 700                
 Glu Asp Leu Glu Glu Leu Tyr Asp Leu Phe Lys Arg Glu His Met Met
 705                 710                 715                 720
 Ser Cys Tyr Trp Glu Gln Pro Arg Pro Met Ala Ser Arg His Asp Pro
                 725                 730                 735    
 Ser Arg Pro Tyr Ala Glu Gln Tyr Arg Ile Asp Ala Arg Gln Phe Ala
             740                 745                 750        
 His Leu Phe Gln Leu Val Ser Pro Trp Thr Cys Gly Ala His Thr Glu
         755                 760                 765            
 Ile Leu Ala Glu Arg Thr Phe Arg Leu Leu Asp Asp Asn Met Asp Gln
     770                 775                 780                
 Leu Ile Glu Phe Lys Ala Phe Val Ser Cys Leu Asp Ile Met Tyr Asn
 785                 790                 795                 800
 Gly Glu Met Asn Glu Lys Ile Lys Leu Leu Tyr Arg Leu His Ile Pro
                 805                 810                 815    
 Pro Ala Leu Thr Glu Asn Asp Arg Asp Ser Gln Ser Pro Leu Arg Asn
             820                 825                 830        
 Pro Leu Leu Ser Thr Ser Arg Pro Leu Val Phe Gly Lys Pro Asn Gly
         835                 840                 845            
 Asp Ala Val Asp Tyr Gln Lys Gln Leu Lys Gln Met Ile Lys Asp Leu
     850                 855                 860                
 Ala Lys Glu Lys Asp Lys Thr Glu Lys Glu Leu Pro Lys Met Ser Gln
 865                 870                 875                 880
 Arg Glu Phe Ile Gln Phe Cys Lys Thr Leu Tyr Ser Met Phe His Glu
                 885                 890                 895    
 Asp Pro Glu Glu Asn Asp Leu Tyr Gln Ala Ile Ala Thr Val Thr Thr
             900                 905                 910        
 Leu Leu Leu Gln Ile Gly Glu Val Gly Gln Arg Gly Ser Ser Ser Gly
         915                 920                 925            
 Ser Cys Ser Gln Glu Cys Gly Glu Glu Leu Arg Ala Ser Ala Pro Ser
     930                 935                 940                
 Pro Glu Asp Ser Val Phe Ala Asp Thr Gly Lys Thr Pro Gln Asp Ser
 945                 950                 955                 960
 Gln Ala Phe Pro Glu Ala Ala Glu Arg Asp Trp Thr Val Ser Leu Glu
                 965                 970                 975    
 His Ile Leu Ala Ser Leu Leu Thr Glu Gln Ser Leu Val Asn Phe Phe
             980                 985                 990        
 Glu Lys Pro Leu Asp Met Lys Ser Lys Leu Glu Asn Ala Lys Ile Asn
         995                1000                1005            
 Gln Tyr Asn Leu Lys Thr Phe Glu Met Ser His Gln Ser Gln Ser Glu
    1010                1015                1020                
 Leu Lys Leu Ser Asn Leu
1025                1030



      <210> 2557
      <211> 120
      <212> PRT
      <213> Homo sapiens

      <220>
      <221> misc_feature
      <222> (1)...(120)
      <223> Xaa = any amino acid or symbol as shown in the table 8 as set forth in Example 2


      <400> 2557
 Gln Gly Tyr Trp Arg Gly Cys Thr Ser Ser Gly Gly Asp Gly Gly Cys
   1               5                  10                  15    
 Arg Gly Cys Trp Ser Pro Gly Lys Arg Arg Xaa Gly Leu Ser Arg Thr
              20                  25                  30        
 Ala Ser Gly Pro Pro Ala Ala Val Ala Ser Pro Gly Arg Pro Arg Ser
          35                  40                  45            
 Pro Pro Ser Ala Arg Thr Gly Xaa Ser Xaa Pro Gly Ala Xaa Ala Arg
      50                  55                  60                
 Pro Cys Ser Arg Thr Trp Pro Pro Pro Arg Cys Pro Leu Arg Pro Pro
  65                  70                  75                  80
 Ser Ala Ala Arg Ala Ser Ala Ser Arg Val Ala Pro Leu Gly Glu Pro
                  85                  90                  95    
 Ala Pro Ala Asn Thr Asn Ile Tyr Cys Ala Ala Leu Thr His Arg Ala
             100                 105                 110        
 Thr Lys Ser Ser Thr Arg Glu Phe
         115                 120



      <210> 2558
      <211> 127
      <212> PRT
      <213> Homo sapiens


      <400> 2558
 Pro Asp Ile Met Ser Gly Cys Arg Val Phe Ile Gly Arg Leu Asn Pro
   1               5                  10                  15    
 Ala Ala Arg Glu Lys Asp Val Glu Arg Phe Phe Lys Gly Tyr Gly Arg
              20                  25                  30        
 Ile Arg Asp Ile Asp Leu Lys Arg Gly Phe Gly Phe Val Glu Phe Glu
          35                  40                  45            
 Asp Pro Lys Asp Ala Asp Asp Ala Val Tyr Glu Leu Asp Gly Lys Glu
      50                  55                  60                
 Leu Cys Ser Glu Arg Val Thr Ile Glu His Ala Arg Ala Arg Ser Arg
  65                  70                  75                  80
 Gly Gly Arg Gly Arg Gly Arg Tyr Ser Asp Arg Phe Ser Ser Arg Arg
                  85                  90                  95    
 Pro Arg Asn Asp Arg Arg Asn Ala Pro Pro Val Arg Thr Glu Asn Arg
             100                 105                 110        
 Leu Ile Val Glu Asn Leu Ser Ser Arg Val Ser Trp Gln Val Cys
         115                 120                 125        



      <210> 2559
      <211> 120
      <212> PRT
      <213> Homo sapiens


      <400> 2559
 Ser Asn Leu Thr Glu His Lys Arg Val His Thr Gly Glu Lys Pro Tyr
   1               5                  10                  15    
 Lys Cys Glu Gly Cys Gly Lys Thr Phe Thr Cys Ser Ser Thr Leu Val
              20                  25                  30        
 Lys His Lys Arg Asn His Thr Gly Asp Arg Pro Tyr Lys Cys Glu Glu
          35                  40                  45            
 Cys Gly Lys Ala Phe Lys Cys Phe Ser Asp Leu Thr Asn His Lys Arg
      50                  55                  60                
 Ile His Thr Gly Glu Lys Pro Tyr Lys Cys Glu Glu Cys Asn Lys Ala
  65                  70                  75                  80
 Tyr Arg Trp Phe Ser Asp Leu Ala Lys His Lys Ile Ile His Thr Gly
                  85                  90                  95    
 Asp Lys Pro Tyr Thr Cys Asn Glu Cys Gly Lys Ala Phe Lys Trp Phe
             100                 105                 110        
 Ser Ala Leu Ser Lys His Lys Arg
         115                 120



      <210> 2560
      <211> 145
      <212> PRT
      <213> Homo sapiens


      <400> 2560
 Phe Arg Glu Lys Trp Asn Ser Val Ala Asp Cys Leu Pro Cys Val Phe
   1               5                  10                  15    
 Leu Val Asp Phe Glu Phe Gly Cys Ala Thr Ser Tyr Ile Leu Pro Glu
              20                  25                  30        
 Leu Gln Asp Gly Leu Ser Phe His Val Ser Ile Ala Lys Asn Asp Thr
          35                  40                  45            
 Ile Tyr Ile Leu Gly Gly His Ser Leu Ala Asn Asn Ile Arg Pro Ala
      50                  55                  60                
 Asn Leu Tyr Arg Ile Arg Val Asp Leu Pro Leu Gly Ser Pro Ala Val
  65                  70                  75                  80
 Asn Cys Thr Val Leu Pro Gly Gly Ile Ser Val Ser Ser Ala Ile Leu
                  85                  90                  95    
 Thr Gln Thr Asn Asn Asp Glu Phe Val Ile Val Gly Gly Tyr Gln Leu
             100                 105                 110        
 Glu Asn Gln Lys Arg Met Ile Cys Asn Ile Ile Ser Leu Glu Asp Asn
         115                 120                 125            
 Lys Ile Glu Ile Arg Glu Met Glu Thr Pro Asp Trp Thr Pro Asp Ile
     130                 135                 140                
 Lys
 145



      <210> 2561
      <211> 351
      <212> PRT
      <213> Homo sapiens


      <400> 2561
 Ala Glu Trp Asp Ala Ala Asp Lys Ala His Val Gly Pro Gly Arg Ser
   1               5                  10                  15    
 Pro Arg Gln Pro Leu Pro His Val Gly Arg Arg Arg Ala Ala His Thr
              20                  25                  30        
 Thr Gly Arg Gly Arg Arg Thr Ala Gly Cys Ala Pro Ala Pro Ala Arg
          35                  40                  45            
 Thr Leu Cys Ile Leu Ser Ile Leu Gly Pro Trp Cys Val Leu Pro His
      50                  55                  60                
 Leu Pro Thr Leu Cys Leu Gly Gln Ala Gln Ala Ala Ser Cys Ser Gln
  65                  70                  75                  80
 Gly Ala His Gly Cys Phe Ala Gly Cys Ser Cys Thr Gly Thr Ser Ala
                  85                  90                  95    
 Ser His Pro Val Cys Cys Lys Cys Pro Leu His Pro Val Cys Thr Leu
             100                 105                 110        
 Ala Asp Val His Gly Cys Ile Thr Ser Gly Phe Ser Val Ile Ser Leu
         115                 120                 125            
 Pro Gln Thr Cys Ala Pro Trp Thr Ser Trp Arg Lys Trp Ser Leu Ser
     130                 135                 140                
 Asp Ser Trp Gln Val Asp Ala Cys Pro Glu Ser Cys Cys Glu Pro Pro
 145                 150                 155                 160
 Cys Cys Ala Thr Ser Cys Cys Ala Pro Ala Pro Cys Leu Thr Leu Val
                 165                 170                 175    
 Cys Thr Pro Val Ser Cys Val Ser Ser Pro Cys Cys Gln Ala Ala Cys
             180                 185                 190        
 Glu Pro Ser Pro Cys Gln Ser Gly Cys Thr Ser Ser Cys Thr Pro Ser
         195                 200                 205            
 Cys Cys Gln Gln Ser Ser Cys Gln Pro Ala Cys Cys Thr Ser Ser Pro
     210                 215                 220                
 Cys Gln Gln Ala Cys Cys Val Pro Val Cys Cys Lys Pro Val Cys Cys
 225                 230                 235                 240
 Val Pro Val Cys Cys Lys Pro Val Cys Cys Lys Pro Ile Cys Cys Val
                 245                 250                 255    
 Pro Val Cys Ser Gly Ala Ser Ser Ser Cys Cys Gln Gln Ser Ser Arg
             260                 265                 270        
 Gln Pro Ala Cys Cys Thr Thr Ser Cys Cys Arg Pro Ser Ser Ser Val
         275                 280                 285            
 Ser Leu Leu Cys Arg Pro Val Cys Arg Ser Thr Cys Cys Val Pro Ile
     290                 295                 300                
 Pro Ser Cys Cys Ala Pro Ala Ser Thr Cys Gln Pro Ser Cys Cys Arg
 305                 310                 315                 320
 Pro Ala Ser Cys Val Ser Leu Leu Cys Arg Pro Thr Cys Ser Arg Leu
                 325                 330                 335    
 Ser Ser Ala Cys Cys Gly Leu Ser Ser Gly Gln Lys Ser Ser Cys
             340                 345                 350    



      <210> 2562
      <211> 55
      <212> PRT
      <213> Homo sapiens


      <400> 2562
 Gly Asn Gly Gly Ala Ala Ala Ala Met Leu Pro Thr Pro Ser Pro Thr
   1               5                  10                  15    
 Lys Lys Arg Glu Arg Cys Ser Arg Thr Arg Glu Arg Ser Gln Ala Arg
              20                  25                  30        
 Gly Gln Lys Ser Arg Asp Cys Asn Arg Phe Gly Val Ser Leu Glu Val
          35                  40                  45            
 Arg Tyr Ala Gln Glu Leu Gly
      50                  55



      <210> 2563
      <211> 58
      <212> PRT
      <213> Homo sapiens


      <400> 2563
 Ser Phe Glu Leu Phe Ala Asp Lys Val Pro Lys Thr Ala Trp Leu Asp
   1               5                  10                  15    
 Gly Lys His Val Val Phe Gly Lys Val Lys Glu Gly Met Asn Ile Val
              20                  25                  30        
 Glu Ala Met Glu Arg Phe Gly Ser Arg Asn Gly Lys Thr Ser Lys Lys
          35                  40                  45            
 Ile Thr Ile Ala Asp Cys Gly Gln Leu Glu
      50                  55            



      <210> 2564
      <211> 670
      <212> PRT
      <213> Homo sapiens

      <220>
      <221> misc_feature
      <222> (1)...(670)
      <223> Xaa = any amino acid or symbol as shown in the table 8 as set forth in Example 2


      <400> 2564
 Met Pro Arg Ser His Thr Gly Glu Arg Leu Cys Glu Gly Lys Glu Gly
   1               5                  10                  15    
 Ser Gln Cys Ala Glu Asn Phe Ser Pro Asn Leu Ser Val Thr Lys Lys
              20                  25                  30        
 Thr Ala Gly Val Lys Pro Tyr Glu Cys Thr Ile Cys Gly Lys Ala Phe
          35                  40                  45            
 Met Arg Leu Ser Ser Leu Thr Arg His Met Arg Ser His Thr Ala Ile
      50                  55                  60                
 Arg Ala Ile Glu Lys Pro Tyr Lys Cys Lys Glu Cys Gly Arg Ala Phe
  65                  70                  75                  80
 Ser Leu Ser Gln Ile Leu Ser Lys His Glu Arg Ser His Thr Gly Glu
                  85                  90                  95    
 Lys Pro Tyr Lys Cys Lys Gln Cys Gly Lys Thr Phe Ile Tyr His Gln
             100                 105                 110        
 Pro Phe Gln Arg His Glu Arg Thr His Ile Gly Glu Lys Pro Tyr Glu
         115                 120                 125            
 Cys Lys Gln Cys Gly Lys Ala Leu Ser Cys Ser Ser Ser Leu Arg Val
     130                 135                 140                
 His Glu Arg Ile His Thr Gly Glu Lys Pro Tyr Glu Cys Lys Gln Cys
 145                 150                 155                 160
 Gly Lys Ala Phe Ser Cys Ser Ser Ser Ile Arg Val His Glu Arg Thr
                 165                 170                 175    
 His Thr Gly Glu Lys Pro Tyr Ala Cys Lys Glu Cys Gly Lys Ala Phe
             180                 185                 190        
 Ile Ser Thr Thr Ser Val Leu Thr His Met Ile Thr His Asn Gly Asp
         195                 200                 205            
 Arg Pro Tyr Lys Cys Lys Glu Cys Gly Lys Ala Phe Ile Phe Pro Ser
     210                 215                 220                
 Phe Leu Arg Val His Glu Arg Ile His Thr Gly Glu Lys Pro Tyr Lys
 225                 230                 235                 240
 Cys Lys Gln Cys Gly Lys Ala Phe Arg Trp Ser Thr Ser Ile Gln Ile
                 245                 250                 255    
 His Glu Arg Ile His Thr Gly Glu Lys Pro Tyr Lys Cys Lys Glu Cys
             260                 265                 270        
 Gly Lys Ser Phe Ser Ala Arg Pro Ala Phe Arg Val His Val Arg Val
         275                 280                 285            
 His Thr Gly Glu Lys Pro Tyr Lys Cys Lys Glu Cys Gly Lys Ala Phe
     290                 295                 300                
 Ser Arg Ile Ser Tyr Phe Arg Ile His Glu Arg Thr His Thr Gly Glu
 305                 310                 315                 320
 Lys Pro Tyr Glu Cys Lys Lys Cys Gly Lys Thr Phe Asn Tyr Pro Leu
                 325                 330                 335    
 Asp Leu Lys Ile His Lys Arg Asn His Thr Gly Glu Lys Pro Tyr Glu
             340                 345                 350        
 Cys Lys Glu Cys Ala Lys Thr Phe Ile Ser Leu Glu Asn Phe Arg Arg
         355                 360                 365            
 His Met Ile Thr His Thr Gly Asp Gly Pro Tyr Lys Cys Arg Asp Cys
     370                 375                 380                
 Gly Lys Val Phe Ile Phe Pro Ser Ala Leu Arg Thr His Glu Arg Thr
 385                 390                 395                 400
 His Thr Gly Glu Lys Pro Tyr Glu Cys Lys Gln Cys Gly Lys Ala Phe
                 405                 410                 415    
 Ser Cys Ser Ser Tyr Ile Arg Ile His Lys Arg Thr His Thr Gly Glu
             420                 425                 430        
 Lys Pro Tyr Glu Cys Lys Glu Cys Gly Lys Ala Phe Ile Tyr Pro Thr
         435                 440                 445            
 Ser Phe Gln Gly His Met Arg Met His Thr Gly Glu Lys Pro Tyr Lys
     450                 455                 460                
 Cys Lys Glu Cys Gly Lys Ala Phe Ser Leu His Ser Ser Phe Arg Arg
 465                 470                 475                 480
 His Thr Arg Ile His Asn Tyr Glu Lys Pro Leu Glu Cys Xaa Gln Cys
                 485                 490                 495    
 Gly Lys Ala Phe Ser Val Ser Thr Ser Leu Lys Lys Pro Met Arg Asn
             500                 505                 510        
 Ala Gln Ser Asp Arg Lys Leu Tyr Lys Cys Glu Lys Xaa Glu Lys Val
         515                 520                 525            
 Phe Asn Ser Asn Arg Cys Phe Gln Ser Cys Glu Asn Ser His Xaa Arg
     530                 535                 540                
 Glu Lys Ser Cys Gln Cys Lys Xaa Tyr Arg Lys Arg Asp Thr Arg Xaa
 545                 550                 555                 560
 Phe Met Tyr Ser Gln Val Pro His Asn His Val Ser Val Ser Asn Gly
                 565                 570                 575    
 Pro Tyr Arg Cys Gly Ser Pro Ile Arg Leu Tyr Asn Thr Xaa Asn Ile
             580                 585                 590        
 Ser Ile Asn Arg Asn Leu Val Ala Val Val Thr Pro Xaa Cys Ser Thr
         595                 600                 605            
 Leu Phe Lys Cys Leu Trp Cys Trp Cys Lys Arg Ala Ala Leu Ser Val
     610                 615                 620                
 Val Xaa Ile Val Gln Asp Ser Gly Arg Gly Arg Trp Leu Thr Pro Val
 625                 630                 635                 640
 Ile Pro Ala Leu Trp Glu Ala Lys Ala Gly Gly Ser Arg Gly Gln Glu
                 645                 650                 655    
 Ile Lys Thr Ile Leu Ala Asn Thr Val Lys Pro His Leu Tyr
             660                 665                 670

      <210> 2565
      <211> 145
      <212> PRT
      <213> Homo sapiens


      <400> 2565
 Val Ser Phe Leu Ser Ser Phe Phe Leu Ser Leu Pro Tyr Gly Val Ala
   1               5                  10                  15    
 Val Gly Val Ala Phe Ser Val Leu Val Val Val Phe Gln Thr Gln Phe
              20                  25                  30        
 Arg Asn Gly Tyr Ala Leu Ala Gln Val Met Asp Thr Asp Ile Tyr Val
          35                  40                  45            
 Asn Pro Lys Thr Tyr Asn Arg Ala Gln Asp Ile Gln Gly Ile Lys Ile
      50                  55                  60                
 Ile Thr Tyr Cys Ser Pro Leu Tyr Phe Ala Asn Ser Glu Ile Phe Arg
  65                  70                  75                  80
 Gln Lys Val Ile Ala Lys Thr Gly Met Asp Pro Gln Lys Val Leu Leu
                  85                  90                  95    
 Ala Lys Gln Lys Tyr Leu Lys Lys Gln Glu Lys Arg Arg Met Arg Pro
             100                 105                 110        
 Thr Gln Gln Arg Arg Ser Leu Phe Met Lys Thr Lys Thr Val Ser Leu
         115                 120                 125            
 Gln Glu Leu Gln Gln Asp Phe Glu Asn Ala Pro Pro Thr Asp Pro Met
     130                 135                 140                
 Tyr
 145



      <210> 2566
      <211> 314
      <212> PRT
      <213> Homo sapiens


      <400> 2566
 Ser Gly Leu Phe Ser Val Asp Pro Ala Ser Ser Gln Ala Met Glu Leu
   1               5                  10                  15    
 Ser Asp Val Thr Leu Ile Glu Gly Val Gly Asn Glu Val Met Val Val
              20                  25                  30        
 Ala Gly Val Val Val Leu Ile Leu Ala Leu Val Leu Ala Trp Leu Ser
          35                  40                  45            
 Thr Tyr Val Ala Asp Ser Gly Ser Asn Gln Leu Leu Gly Ala Ile Val
      50                  55                  60                
 Ser Ala Gly Asp Thr Ser Val Leu His Leu Gly His Val Asp His Leu
  65                  70                  75                  80
 Val Ala Gly Gln Gly Asn Pro Glu Pro Thr Glu Leu Pro His Pro Ser
                  85                  90                  95    
 Glu Gly Asn Asp Glu Lys Ala Glu Glu Ala Gly Glu Gly Arg Gly Asp
             100                 105                 110        
 Ser Thr Gly Glu Ala Gly Ala Gly Gly Gly Val Glu Pro Ser Leu Glu
         115                 120                 125            
 His Leu Leu Asp Ile Gln Gly Leu Pro Lys Arg Gln Ala Gly Ala Gly
     130                 135                 140                
 Ser Ser Ser Pro Glu Ala Pro Leu Arg Ser Glu Asp Ser Thr Cys Leu
 145                 150                 155                 160
 Pro Pro Ser Pro Gly Leu Ile Thr Val Arg Leu Lys Phe Leu Asn Asp
                 165                 170                 175    
 Thr Glu Glu Leu Ala Val Ala Arg Pro Glu Asp Thr Val Gly Ala Leu
             180                 185                 190        
 Lys Ser Lys Tyr Phe Pro Gly Gln Glu Ser Gln Met Lys Leu Ile Tyr
         195                 200                 205            
 Gln Gly Arg Leu Leu Gln Asp Pro Ala Arg Thr Leu Arg Ser Leu Asn
     210                 215                 220                
 Ile Thr Asp Asn Cys Val Ile His Cys His Arg Ser Pro Pro Gly Ser
 225                 230                 235                 240
 Ala Val Pro Gly Pro Ser Ala Ser Leu Ala Pro Ser Ala Thr Glu Pro
                 245                 250                 255    
 Pro Ser Leu Gly Val Asn Val Gly Ser Leu Met Val Pro Val Phe Val
             260                 265                 270        
 Val Leu Leu Gly Val Val Trp Tyr Phe Arg Ile Asn Tyr Arg Gln Phe
         275                 280                 285            
 Phe Thr Ala Pro Ala Thr Val Ser Leu Val Gly Val Thr Val Phe Phe
     290                 295                 300                
 Ser Phe Leu Val Phe Gly Met Tyr Gly Arg
 305                 310                



      <210> 2567
      <211> 141
      <212> PRT
      <213> Homo sapiens


      <400> 2567
 Arg Thr Arg Gly Arg Thr Arg Gly Arg Thr Arg Gly Arg Gly Gly Val
   1               5                  10                  15    
 Ala Ala Met Ala Thr Ala Ala Gly Ala Thr Tyr Phe Gln Arg Gly Ser
              20                  25                  30        
 Leu Phe Trp Phe Thr Val Ile Thr Pro Ala Leu Ala Thr Thr His Gly
          35                  40                  45            
 Leu Ser Ser Gly Pro Glu Tyr Pro Leu Ser Glu Pro Trp Ala Pro Gly
      50                  55                  60                
 Pro Leu His Ser Val Leu Gly Gly Pro Pro Phe Thr Ala Leu Leu Cys
  65                  70                  75                  80
 Asn Gly Tyr Trp Leu Ala Trp Leu Ile His Val Gly Glu Ser Leu Tyr
                  85                  90                  95    
 Ala Ile Val Leu Cys Lys His Lys Gly Ile Thr Ser Gly Arg Ala Gln
             100                 105                 110        
 Leu Leu Trp Phe Leu Gln Thr Phe Phe Phe Gly Ile Ala Ser Leu Thr
         115                 120                 125            
 Ile Leu Ile Ala Tyr Lys Arg Lys Arg Gln Lys Gln Thr
     130                 135                 140    



      <210> 2568
      <211> 123
      <212> PRT
      <213> Homo sapiens


      <400> 2568
 Ser Pro Ala Arg Gly Lys Ser Asn Arg Thr Asp Val Met Ile Thr Ala
   1               5                  10                  15    
 Pro Lys Asn Lys Lys Met Thr Glu Asn Leu Ala Ala Pro Glu Ala Leu
              20                  25                  30        
 Asp Ser Ser Thr His Ser Ser Ser Thr Ala Thr Gln Ser Arg Ala Lys
          35                  40                  45            
 Met Asn Thr Pro Ala Pro Thr Pro Ser Thr Val Pro Ala Ile Pro Arg
      50                  55                  60                
 Gly Gly Ser Gly Gly Pro Pro Pro Cys Ala Pro His Asp Arg Val Ser
  65                  70                  75                  80
 Ser Val Leu Gln Cys Asp Thr Gln Ala Met Asp His Lys Thr Glu Ser
                  85                  90                  95    
 Ser His Ser Val Val Glu Phe Leu Phe Lys Arg Thr Lys Thr Pro Ser
             100                 105                 110        
 Pro Phe His Pro Ala Val Arg Glu Asn Arg Asn
         115                 120            



      <210> 2569
      <211> 109
      <212> PRT
      <213> Homo sapiens

      <220>
      <221> misc_feature
      <222> (1)...(109)
      <223> Xaa = any amino acid or symbol as shown in the table 8 as set forth in Example 2


      <400> 2569
 Glu Gln Ala Val Cys Val Gly Trp Leu Gln Ile Pro Arg Gly Thr Lys
   1               5                  10                  15    
 Arg Pro Lys Pro Pro Gly Gly Thr His Gly Arg Thr Asp Gly Arg Arg
              20                  25                  30        
 Glu Pro Glu Arg Thr Gly Gly Gly Xaa Ala Pro Arg Ala Ala Lys Glu
          35                  40                  45            
 Glu Lys Leu Thr Thr Ala Lys Leu Pro Arg Arg Leu Ser Phe Ala Ala
      50                  55                  60                
 Leu Arg Asn Glu Thr Leu Pro Ala Arg Ser Ala Leu Arg Leu Leu Leu
  65                  70                  75                  80
 Pro Leu Gln Ser Arg Ala Gly Pro Pro Glu Glu Arg Met Leu Ser Gly
                  85                  90                  95    
 Ala Gly Leu His Gly Gln Gly Gln Val Ser Glu Asn Glu
             100                 105                



      <210> 2570
      <211> 139
      <212> PRT
      <213> Homo sapiens


      <400> 2570
 Lys Asn Glu Arg Gln Thr Thr Asp Ile Ser Val His Val Cys Cys Gln
   1               5                  10                  15    
 Ile Leu Lys Arg Gly Ser His Tyr Ser Asn Thr Gln Ser Gln Pro Gln
              20                  25                  30        
 Glu Gly Gly Thr Gln His Gln Gly Gly Glu Pro Pro Gln Leu Ala Pro
          35                  40                  45            
 Gly Pro Thr Ala Leu Pro Gly Glu Pro Pro Pro Pro Pro Ala Pro Ala
      50                  55                  60                
 His Ser Pro Pro Gly Pro Pro Pro Ala Gly Ala Ala Ala Pro Gln Pro
  65                  70                  75                  80
 Gly Ala Arg Pro His Gly Ala Pro Pro Leu Thr Pro Ala Arg Arg Leu
                  85                  90                  95    
 Arg Arg Ser Arg Leu Ala Ala Ala Ala Leu Leu Ser Arg Thr Ser Gly
             100                 105                 110        
 Ala Pro Arg Arg Ala Leu Ala Pro Thr Pro Gly Thr Gly Val Pro Pro
         115                 120                 125            
 Gly Pro Pro Pro Ser Gly Pro Pro Gly Asn Glu
     130                 135                



      <210> 2571
      <211> 196
      <212> PRT
      <213> Homo sapiens


      <400> 2571
 Leu Pro Leu Arg Phe Gln Arg Leu Gly His Leu Val Ala Leu Met Ala
   1               5                  10                  15    
 Leu Leu Cys Gly Asp Pro Gln Glu Lys Val Ala Glu Glu Ala Ala Glu
              20                  25                  30        
 Gly Ile His Ser Leu Leu His Ile Thr Leu Arg Leu Lys Tyr Ile Thr
          35                  40                  45            
 His Asp Lys Lys Asp Gln Gln Asn Leu Lys Arg Ala Leu Thr Lys Cys
      50                  55                  60                
 Arg Glu Phe Leu Glu Leu His Ser Ser Ala Ala Lys Cys Phe Tyr Asn
  65                  70                  75                  80
 Cys Pro Phe Arg Ile Ala Gln Val Phe Glu Gly Phe Leu Asp Ser Asn
                  85                  90                  95    
 Glu Leu Cys Gln Phe Ile Met Thr Thr Phe Asp Thr Leu Lys Asn Leu
             100                 105                 110        
 Lys His Pro Cys Ile Gln Arg Ser Ala Gly Glu Leu Leu Leu Thr Leu
         115                 120                 125            
 Ala Lys Asn Thr Glu Ser Gln Phe Glu Lys Val Pro Glu Ile Met Gly
     130                 135                 140                
 Val Ile Cys Ala Gln Leu Pro Ile Ile Ser Gln Pro Arg Val Arg Gln
 145                 150                 155                 160
 Gln Ile Ile Asn Thr Val Ser Leu Phe Ile Ser Arg Pro Lys Tyr Thr
                 165                 170                 175    
 Asp Ile Val Leu Ser Leu Pro Phe Cys Val Ile Pro Val Pro Tyr Asn
             180                 185                 190        
 Arg His Leu Ala
         195    



      <210> 2572
      <211> 157
      <212> PRT
      <213> Homo sapiens


      <400> 2572
 Met Phe Val Ile Ala Phe Leu Ser Pro Leu Ser Leu Ile Phe Leu Ala
   1               5                  10                  15    
 Lys Phe Leu Lys Lys Ala Asp Thr Arg Asp Ser Arg Gln Ala Cys Leu
              20                  25                  30        
 Ala Ala Ser Leu Ala Leu Ala Leu Asn Gly Val Phe Thr Asn Thr Ile
          35                  40                  45            
 Lys Leu Ile Val Gly Arg Pro Arg Pro Asp Phe Phe Tyr Arg Cys Phe
      50                  55                  60                
 Pro Asp Gly Leu Ala His Ser Asp Leu Met Cys Thr Gly Asp Lys Asp
  65                  70                  75                  80
 Val Val Asn Glu Gly Arg Lys Ser Phe Pro Ser Gly His Ser Ser Phe
                  85                  90                  95    
 Ala Phe Ala Gly Leu Ala Phe Ala Ser Phe Tyr Leu Ala Gly Lys Leu
             100                 105                 110        
 His Cys Phe Thr Pro Gln Gly Arg Gly Lys Ser Trp Arg Phe Cys Ala
         115                 120                 125            
 Phe Leu Ser Pro Leu Leu Phe Ala Ala Val Ile Ala Leu Ser Arg Thr
     130                 135                 140                
 Cys Asp Tyr Lys His His Trp Gln Gly Pro Phe Lys Trp
 145                 150                 155        



      <210> 2573
      <211> 116
      <212> PRT
      <213> Homo sapiens

      <220>
      <221> misc_feature
      <222> (1)...(116)
      <223> Xaa = any amino acid or symbol as shown in the table 8 as set forth in Example 2


      <400> 2573
 Glu Asp Gly Arg His Gly Ala Pro Asn Pro Pro Pro Ala Thr Leu Gly
   1               5                  10                  15    
 Gly Pro Gly Pro Asp Pro Asp Leu Gly Gly Leu Pro Leu His Glu Val
              20                  25                  30        
 Phe Leu His Ile Arg Val Pro Ala Arg Pro Arg Gly Ala Pro Leu His
          35                  40                  45            
 Arg Arg Gly Leu Arg Gly Arg His Ala Val Arg Ala Val Arg Gln Arg
      50                  55                  60                
 Arg Arg Glu Pro Lys Asn Gly Ala Ala Gly Ala Val Asp Arg Ala Gly
  65                  70                  75                  80
 Gly Ala Gly Val Leu Gly Pro Gly Asp Thr Glu Tyr Glu Gly Pro Leu
                  85                  90                  95    
 Thr Asp Xaa Pro Ser Glu Pro Gly Asp Pro Ala Arg Leu Leu Gln Pro
             100                 105                 110        
 Glu Arg Gly Arg
         115    



      <210> 2574
      <211> 310
      <212> PRT
      <213> Homo sapiens

      <220>
      <221> misc_feature
      <222> (1)...(310)
      <223> Xaa = any amino acid or symbol as shown in the table 8 as set forth in Example 2


      <400> 2574
 Ser Leu Ile Ile Gly Gln Tyr Cys Ile Ala Arg Glu Gly Lys Gly Phe
   1               5                  10                  15    
 Thr His Pro Val Gly Gln Leu Ser Cys Leu Gly Gln Lys Leu Tyr Asn
              20                  25                  30        
 Gly Thr Thr Lys Thr Val Thr Trp Trp Ser Ser Asn Tyr Thr Glu Lys
          35                  40                  45            
 Asn Pro Phe Ser Lys Phe Pro Lys Leu Gln Thr Val Trp Ala His Pro
      50                  55                  60                
 Glu Leu His Trp Asp Trp Thr Ala Pro Thr Gly Leu Tyr Trp Val Cys
  65                  70                  75                  80
 Gly His Arg Ala Tyr Ala Lys Leu Pro Asp Gln Trp Thr Gly Ser Cys
                  85                  90                  95    
 Val Ile Gly Thr Ile Lys Pro Ser Phe Phe Leu Val Pro Ile Lys Thr
             100                 105                 110        
 Gly Lys Leu Leu Gly Phe Pro Val Cys Ala Ser Cys Glu Lys Xaa Ser
         115                 120                 125            
 Ile Ala Ile Gly Asp Trp Lys Asp Asp Glu Trp Pro Pro Glu Lys Ile
     130                 135                 140                
 Leu Gln Tyr Tyr Gly Pro Ala Thr Trp Ser Gln Asp Val Ser Trp Gly
 145                 150                 155                 160
 Tyr Gly Thr Pro Ile Tyr Met Leu Asn Arg Ile Ile Trp Leu Gln Ala
                 165                 170                 175    
 Val Leu Glu Ile Ile Thr Asn Lys Thr Thr Gln Ala Leu Thr Val Leu
             180                 185                 190        
 Ala Trp Gln Glu Thr Leu Met Arg Asn Ala Ile Tyr Gln Asn Arg Leu
         195                 200                 205            
 Ala Leu Asp Tyr Leu Leu Ala Ala Glu Gly Gly Val Cys Glu Lys Phe
     210                 215                 220                
 Asp Leu Thr Asn Tyr Cys Leu His Ile Asp Asp Gln Gly Gln Val Val
 225                 230                 235                 240
 Glu Asp Ile Val Lys Asp Ile Thr Lys Leu Ala His Ala Pro Val Gln
                 245                 250                 255    
 Val Trp His Gly Leu Asn Leu Gly Ala Met Phe Gly Asn Trp Phe Pro
             260                 265                 270        
 Ala Ile Gly Gly Phe Lys Thr Leu Ile Ile Arg Val Ile Ile Val Ile
         275                 280                 285            
 Gly Thr Cys Leu Leu Leu Pro Cys Leu Ile Pro Val Phe Leu Gln Met
     290                 295                 300                
 Ile Lys Asn Phe Val Ala
 305                 310



      <210> 2575
      <211> 293
      <212> PRT
      <213> Homo sapiens


      <400> 2575
 Glu His Gly Ala Gly Ala Gly Gly Gly Gly Arg Thr Gly Gly Arg Gly
   1               5                  10                  15    
 Pro Tyr Pro Gly Thr Ala Gly Leu Pro Ala Gln Gly Ala Ala Leu Gly
              20                  25                  30        
 Gly Leu Cys Leu Ala Val Leu Trp Lys Arg Thr Gly Arg Pro Pro Ser
          35                  40                  45            
 Gly Gln Pro Leu Leu Thr Ala Pro Leu Pro Cys Leu Ala Gly Ser Ser
      50                  55                  60                
 Gly His Leu Trp Ala Ala Ser Ala Val Pro Cys Gln Pro Ser Asp Tyr
  65                  70                  75                  80
 Leu Arg Gln Pro Arg Gln Leu Leu Gln Gln Lys Phe Val Asn Ser Ala
                  85                  90                  95    
 Trp Gly Trp Thr Cys Thr Phe Leu Gly Gly Phe Val Leu Leu Val Val
             100                 105                 110        
 Phe Leu Ala Thr Arg Arg Val Ala Val Thr Ala Arg His Leu Ser Arg
         115                 120                 125            
 Leu Val Val Gly Ala Ala Val Trp Arg Gly Ala Gly Arg Ala Phe Leu
     130                 135                 140                
 Leu Ile Glu Asp Leu Thr Gly Ser Cys Phe Glu Pro Leu Pro Gln Gly
 145                 150                 155                 160
 Leu Leu Leu His Glu Leu Pro Asp Arg Arg Ser Cys Leu Ala Ala Gly
                 165                 170                 175    
 His Gln Trp Arg Gly Tyr Thr Val Ser Ser His Thr Phe Leu Leu Thr
             180                 185                 190        
 Phe Cys Cys Leu Leu Met Ala Glu Glu Ala Ala Val Phe Ala Lys Tyr
         195                 200                 205            
 Leu Ala His Gly Leu Pro Ala Gly Ala Pro Leu Arg Leu Val Phe Leu
     210                 215                 220                
 Leu Asn Val Leu Leu Leu Gly Leu Trp Asn Phe Leu Leu Leu Cys Thr
 225                 230                 235                 240
 Val Ile Tyr Phe His Gln Tyr Thr His Lys Val Val Gly Ala Ala Val
                 245                 250                 255    
 Gly Thr Phe Ala Trp Tyr Leu Thr Tyr Gly Ser Trp Tyr His Gln Pro
             260                 265                 270        
 Trp Ser Pro Gly Ser Pro Gly His Gly Leu Phe Pro Arg Pro His Ser
         275                 280                 285            
 Ser Arg Lys His Asn
     290            



      <210> 2576
      <211> 240
      <212> PRT
      <213> Homo sapiens


      <400> 2576
 Arg Pro Ala Ala Asp Pro Gly Leu Thr Cys Ala Ser Ser Ser Ser Leu
   1               5                  10                  15    
 Gly Met Met Thr Gly Thr Ile Glu Thr Thr Gly Asn Ile Ser Ala Glu
              20                  25                  30        
 Lys Gly Gly Ser Ile Ile Leu Gln Cys His Leu Ser Ser Thr Thr Ala
          35                  40                  45            
 Gln Val Thr Gln Val Asn Trp Glu Gln Gln Asp Gln Leu Leu Ala Ile
      50                  55                  60                
 Cys Asn Ala Asp Leu Gly Trp His Ile Ser Pro Ser Phe Lys Asp Arg
  65                  70                  75                  80
 Val Ala Pro Gly Pro Gly Leu Gly Leu Thr Leu Gln Ser Leu Thr Val
                  85                  90                  95    
 Asn Asp Thr Gly Glu Tyr Phe Cys Ile Tyr His Thr Tyr Pro Asp Gly
             100                 105                 110        
 Thr Tyr Thr Gly Arg Ile Phe Leu Glu Val Leu Glu Ser Ser Val Ala
         115                 120                 125            
 Glu His Gly Ala Arg Phe Gln Ile Pro Leu Leu Gly Ala Met Ala Ala
     130                 135                 140                
 Thr Leu Val Val Ile Cys Thr Ala Val Ile Val Val Val Ala Leu Thr
 145                 150                 155                 160
 Arg Lys Lys Lys Ala Leu Arg Ile His Ser Val Glu Gly Asp Leu Arg
                 165                 170                 175    
 Arg Lys Ser Ala Gly Gln Glu Glu Trp Ser Pro Ser Ala Pro Ser Pro
             180                 185                 190        
 Pro Gly Ser Cys Val Gln Ala Glu Ala Ala Pro Ala Gly Leu Cys Gly
         195                 200                 205            
 Glu Gln Arg Gly Glu Asp Cys Ala Glu Leu His Asp Tyr Phe Asn Val
     210                 215                 220                
 Leu Ser Tyr Arg Ser Leu Gly Asn Cys Ser Phe Phe Thr Glu Thr Gly
 225                 230                 235                 240





      <210> 2577
      <211> 57
      <212> PRT
      <213> Homo sapiens


      <400> 2577
 Met Gln Gly Val Arg Val Ser Phe Gly Trp Ala Met Gly Leu Ala Trp
   1               5                  10                  15    
 Gly Ser Cys Ala Leu Glu Ala Phe Ser Gly Thr Leu Leu Leu Ser Ala
              20                  25                  30        
 Ala Trp Thr Leu Ser Leu Ser Pro Pro Ile Cys Gly His Leu Ser Pro
          35                  40                  45            
 Gln Gln Val Gly Gly Arg Gly Gly Asp
      50                  55        



      <210> 2578
      <211> 146
      <212> PRT
      <213> Homo sapiens


      <400> 2578
 Pro Tyr Arg Pro Glu Phe Pro Gly Ser Ala Ala Gly Val Ala Thr Ile
   1               5                  10                  15    
 Leu Arg Thr Leu Ala Met Lys Ala Leu Met Leu Leu Thr Leu Ser Val
              20                  25                  30        
 Leu Leu Cys Trp Val Ser Ala Asp Ile Arg Cys His Ser Cys Tyr Lys
          35                  40                  45            
 Val Pro Val Leu Gly Cys Val Asp Arg Gln Ser Cys Arg Leu Glu Pro
      50                  55                  60                
 Gly Gln Gln Cys Leu Thr Thr His Ala Tyr Leu Gly Lys Met Trp Val
  65                  70                  75                  80
 Phe Ser Asn Leu Arg Cys Gly Thr Pro Glu Glu Pro Cys Gln Glu Ala
                  85                  90                  95    
 Phe Asn Gln Thr Asn Arg Lys Leu Gly Leu Thr Tyr Asn Thr Thr Cys
             100                 105                 110        
 Cys Asn Lys Asp Asn Cys Asn Ser Ala Gly Pro Arg Pro Thr Pro Ala
         115                 120                 125            
 Leu Gly Leu Val Phe Leu Thr Ser Leu Ala Gly Leu Gly Leu Trp Leu
     130                 135                 140                
 Leu His
 145    



      <210> 2579
      <211> 580
      <212> PRT
      <213> Homo sapiens


      <400> 2579
 Asn Ser Leu Gln Arg Ser His Pro Asn Ala Ala Asn Ser Trp His Asn
   1               5                  10                  15    
 Lys Leu Trp Arg Ser His Ser Asp Ser Asp Leu Ser Asp His His Glu
              20                  25                  30        
 Pro Ile Cys Lys Pro Gly Leu Glu Leu Asn Lys Lys Asp Ile Thr Thr
          35                  40                  45            
 Ser Ala Asp Gln Ile Ala Glu Val Lys Thr Met Glu Ser His Pro Pro
      50                  55                  60                
 Ile Pro Pro Val Phe Val Glu His Met Val Pro Gln Asp Ala Asn Gln
  65                  70                  75                  80
 Lys Gly Leu Cys Thr Lys Glu Arg Met Ile Cys Leu Glu Phe Thr Ser
                  85                  90                  95    
 Arg Glu Phe His Ala Gly Gln Ile Glu Asp Glu Leu Asn Leu Asn Asp
             100                 105                 110        
 Ile Asn Gly Cys Ser Ser Gly Ser Thr Leu Glu Asp Pro Gln Phe Asn
         115                 120                 125            
 Asp Asp Ser Pro Glu Ala Arg Lys Ile Thr Arg Arg Trp Arg Ile Gly
     130                 135                 140                
 Glu Ala Ala Asp Leu Val Gly Val Ser Ser Gln Ala Ile Arg Asp Ala
 145                 150                 155                 160
 Glu Lys Ala Gly Arg Leu Pro His Pro Asp Met Glu Ile Arg Gly Arg
                 165                 170                 175    
 Val Glu Gln Arg Val Gly Tyr Thr Ile Glu Gln Ile Asn His Met Arg
             180                 185                 190        
 Asp Val Phe Gly Thr Arg Leu Arg Arg Ala Glu Asp Val Phe Pro Pro
         195                 200                 205            
 Val Ile Gly Val Ala Ala His Lys Gly Gly Val Tyr Lys Thr Ser Val
     210                 215                 220                
 Ser Val His Leu Ala Gln Asp Leu Ala Leu Lys Gly Leu Arg Val Leu
 225                 230                 235                 240
 Leu Val Glu Gly Asn Asp Pro Gln Gly Thr Ala Ser Met Tyr His Gly
                 245                 250                 255    
 Trp Val Pro Asp Leu His Ile His Ala Glu Asp Thr Leu Leu Pro Phe
             260                 265                 270        
 Tyr Leu Gly Glu Lys Asp Asp Val Thr Tyr Ala Ile Lys Pro Thr Cys
         275                 280                 285            
 Trp Pro Gly Leu Asp Ile Ile Pro Ser Cys Leu Ala Leu His Arg Ile
     290                 295                 300                
 Glu Thr Glu Leu Met Gly Lys Phe Asp Glu Gly Lys Leu Pro Thr Asp
 305                 310                 315                 320
 Pro His Leu Met Leu Arg Leu Ala Ile Glu Thr Val Ala His Asp Tyr
                 325                 330                 335    
 Asp Val Ile Val Ile Asp Ser Ala Pro Asn Leu Glu Asp Pro Arg Val
             340                 345                 350        
 Gly Val Met Ala Arg Gly Asn Ala Ile Thr Leu Pro Val Cys Gly Arg
         355                 360                 365            
 Asp Val Lys Phe Thr Leu Glu Val Leu Arg Gly Asp Ser Val Glu Lys
     370                 375                 380                
 Thr Ser Arg Val Trp Ser Gly Asn Glu Arg Asp Gln Glu Leu Leu Thr
 385                 390                 395                 400
 Glu Asp Ala Leu Asp Asp Leu Ile Pro Ser Phe Leu Leu Thr Gly Gln
                 405                 410                 415    
 Gln Thr Pro Ala Phe Gly Arg Arg Val Ser Gly Val Ile Glu Ile Ala
             420                 425                 430        
 Asp Gly Ser Arg Arg Arg Lys Ala Ala Ala Leu Thr Glu Ser Asp Tyr
         435                 440                 445            
 Arg Val Leu Val Gly Glu Leu Asp Asp Glu Gln Met Ala Ala Leu Ser
     450                 455                 460                
 Arg Leu Gly Asn Asp Tyr Arg Pro Thr Ser Ala Tyr Glu Arg Gly Gln
 465                 470                 475                 480
 Arg Tyr Ala Ser Arg Leu Gln Asn Glu Phe Ala Gly Asn Ile Ser Ala
                 485                 490                 495    
 Leu Ala Asp Ala Glu Asn Ile Ser Arg Lys Ile Ile Thr Arg Cys Ile
             500                 505                 510        
 Asn Thr Ala Lys Leu Pro Lys Ser Val Val Ala Leu Phe Ser His Pro
         515                 520                 525            
 Gly Glu Leu Ser Ala Arg Ser Gly Asp Ala Leu Gln Lys Ala Phe Thr
     530                 535                 540                
 Asp Lys Glu Glu Leu Leu Lys Gln Gln Ala Ser Asn Leu His Glu Gln
 545                 550                 555                 560
 Lys Lys Ala Gly Val Ile Phe Glu Ala Glu Glu Val Ile Thr Leu Leu
                 565                 570                 575    
 Thr Ser Val Leu
             580



      <210> 2580
      <211> 76
      <212> PRT
      <213> Homo sapiens


      <400> 2580
 Thr Gln Ala Thr Val Leu Cys Asp Ile Ile Val Leu Tyr Cys Met Lys
   1               5                  10                  15    
 Lys Arg Leu Tyr Tyr Arg Glu Lys Lys Tyr Lys Tyr Val Glu Asp Tyr
              20                  25                  30        
 Glu Gln Val Gly Pro Ser Trp Pro Pro Ala Gly Thr Gly Leu Ser Ser
          35                  40                  45            
 Leu Gly Cys Gly Ser Pro Gly Arg Gly Pro Val Trp Gly Gly Pro Ser
      50                  55                  60                
 Ala Glu Ala Gly Thr Ser Val Ala Trp Cys Pro Arg
  65                  70                  75    



      <210> 2581
      <211> 105
      <212> PRT
      <213> Homo sapiens


      <400> 2581
 Met Ile Lys Leu Ser Ala Trp Gln Gly His Gly Leu Arg Ala Gln Lys
   1               5                  10                  15    
 Val Ser Pro Ile His Thr Ser Ala Arg Leu Arg Trp Pro Gly Leu Val
              20                  25                  30        
 Trp Glu Gly Arg Ala Pro Val Cys Ser His Ser Gln Gln Pro Pro Thr
          35                  40                  45            
 Tyr Thr Arg Val Phe Gly Ser Ile Ser Gly Pro Lys Thr Leu Leu Pro
      50                  55                  60                
 Ala Leu Pro Gly Leu Cys Pro His Pro Trp His His Ala Ala Pro Gly
  65                  70                  75                  80
 Val Leu Asp Trp Ala Gly Ile His Leu Pro Ala Pro Gly His His His
                  85                  90                  95    
 Cys Cys Ser Val Asp Arg Arg Gly His
             100                 105



      <210> 2582
      <211> 410
      <212> PRT
      <213> Homo sapiens


      <400> 2582
 Glu Phe Gly Asn Arg Phe Asp Val Asn Asn Cys Ser Ile Cys Tyr His
   1               5                  10                  15    
 Trp Val Thr Ser Arg Pro Gln Glu Pro Ala Val Phe Ser Ala Asp Tyr
              20                  25                  30        
 Arg Gly Cys His Val Leu Glu Lys Asp Gly Arg Phe His Leu Arg Val
          35                  40                  45            
 Phe Met Glu Ala Val Leu Pro Asn Gly Arg Val Asp Val Ala Gln Asp
      50                  55                  60                
 Ala Thr Leu Ile Cys Pro Lys Pro Asp Pro Ser Arg Thr Leu Asp Ser
  65                  70                  75                  80
 Gln Leu Ala Pro Pro Ala Met Phe Ser Val Ser Ile Pro Gln Thr Leu
                  85                  90                  95    
 Ser Phe Leu Pro Thr Ser Gly His Thr Ser Gln Gly Ser Gly His Ala
             100                 105                 110        
 Phe Pro Ser Pro Leu Asp Pro Gly His Ser Ser Val His Pro Thr Pro
         115                 120                 125            
 Ala Leu Pro Ser Pro Gly Pro Gly Pro Thr Leu Ala Thr Leu Ala Gln
     130                 135                 140                
 Pro His Trp Gly Thr Leu Glu His Trp Asp Val Asn Lys Arg Asp Tyr
 145                 150                 155                 160
 Ile Gly Thr His Leu Ser Gln Glu Gln Cys Gln Val Ala Ser Gly His
                 165                 170                 175    
 Leu Pro Cys Ile Val Arg Arg Thr Ser Lys Glu Ala Cys Gln Gln Ala
             180                 185                 190        
 Gly Cys Cys Tyr Asp Asn Thr Arg Glu Val Pro Cys Tyr Tyr Gly Asn
         195                 200                 205            
 Thr Ala Thr Val Gln Cys Phe Arg Asp Gly Tyr Phe Val Leu Val Val
     210                 215                 220                
 Ser Gln Glu Met Ala Leu Thr His Arg Ile Thr Leu Ala Asn Ile His
 225                 230                 235                 240
 Leu Ala Tyr Ala Pro Thr Ser Cys Ser Pro Thr Gln His Thr Glu Ala
                 245                 250                 255    
 Phe Val Val Phe Tyr Phe Pro Leu Thr His Cys Gly Thr Thr Met Gln
             260                 265                 270        
 Val Ala Gly Asp Gln Leu Ile Tyr Glu Asn Trp Leu Val Ser Gly Ile
         275                 280                 285            
 His Ile Gln Lys Gly Pro Gln Gly Ser Ile Thr Arg Asp Ser Thr Phe
     290                 295                 300                
 Gln Leu His Val Arg Cys Val Phe Asn Ala Ser Gly Phe Leu Pro Ile
 305                 310                 315                 320
 Gln Ala Ser Ile Phe Pro Pro Pro Ser Pro Ala Pro Met Thr Gln Pro
                 325                 330                 335    
 Gly Pro Leu Arg Leu Glu Leu Arg Ile Ala Lys Asp Glu Thr Phe Ser
             340                 345                 350        
 Ser Tyr Tyr Gly Glu Asp Asp Tyr Pro Ile Val Arg Leu Leu Arg Glu
         355                 360                 365            
 Pro Val His Val Glu Val Arg Leu Leu Gln Arg Thr Asp Pro Asn Leu
     370                 375                 380                
 Val Leu Leu Leu His Gln Cys Trp Gly Ala Pro Ser Ala Asn Pro Phe
 385                 390                 395                 400
 Gln Gln Pro Gln Trp Pro Ile Leu Ser Asp
                 405                 410



      <210> 2583
      <211> 138
      <212> PRT
      <213> Homo sapiens


      <400> 2583
 Gly Ile Arg Gly Ser Ser His Ala Ser Gly Tyr Val Arg Trp Glu Gly
   1               5                  10                  15    
 Val Phe Arg Cys Ile Pro Ile Phe Gly Met Ser Leu Ala Trp Arg Ser
              20                  25                  30        
 Gln Val Leu Pro Thr Tyr Asp Ser Leu Asp Glu Pro Ser Val Lys Thr
          35                  40                  45            
 Met Ser Ser Ile Phe Ala Ser Ser Leu Asn Val Val Thr Thr Phe Tyr
      50                  55                  60                
 Val Met Gly Gly Phe Phe Gly Tyr Val Ser Phe Thr Glu Ala Thr Ala
  65                  70                  75                  80
 Gly Asn Val Leu Met His Phe Pro Ser Asn Leu Val Thr Glu Met Leu
                  85                  90                  95    
 Arg Val Gly Phe Met Met Ser Val Ala Val Gly Phe Pro Met Met Ile
             100                 105                 110        
 Leu Pro Cys Arg Gln Ala Leu Ser Thr Leu Leu Cys Glu Gln Gln Gln
         115                 120                 125            
 Lys Asp Gly Thr Phe Ala Ala Gly Gly Tyr
     130                 135            



      <210> 2584
      <211> 399
      <212> PRT
      <213> Homo sapiens


      <400> 2584
 Pro Arg Val Arg Leu Leu Arg Pro Ser Arg Ser Arg Ser Cys Arg Gly
   1               5                  10                  15    
 Leu Leu Ser Thr Arg Ala Pro Gly Pro Ser Pro Phe Arg Ser Leu His
              20                  25                  30        
 Ser Ser Pro Leu Leu Pro His Ala Met Lys Ser Pro Phe Tyr Arg Cys
          35                  40                  45            
 Gln Asn Thr Thr Ser Val Glu Lys Gly Asn Ser Ala Val Met Gly Gly
      50                  55                  60                
 Val Leu Phe Ser Thr Gly Leu Leu Gly Asn Leu Leu Ala Leu Gly Leu
  65                  70                  75                  80
 Leu Ala Arg Ser Gly Leu Gly Trp Cys Ser Arg Arg Pro Leu Arg Pro
                  85                  90                  95    
 Leu Pro Ser Val Phe Tyr Met Leu Val Cys Gly Leu Thr Val Thr Asp
             100                 105                 110        
 Leu Leu Gly Lys Cys Leu Leu Ser Pro Val Val Leu Ala Ala Tyr Ala
         115                 120                 125            
 Gln Asn Arg Ser Leu Arg Val Leu Ala Pro Ala Leu Asp Asn Ser Leu
     130                 135                 140                
 Cys Gln Ala Phe Ala Phe Phe Met Ser Phe Phe Gly Leu Ser Ser Thr
 145                 150                 155                 160
 Leu Gln Leu Leu Ala Met Ala Leu Glu Cys Trp Leu Ser Leu Gly His
                 165                 170                 175    
 Pro Phe Phe Tyr Arg Arg His Ile Thr Leu Arg Leu Gly Ala Leu Val
             180                 185                 190        
 Ala Pro Val Val Ser Ala Phe Ser Leu Ala Phe Cys Ala Leu Pro Phe
         195                 200                 205            
 Met Gly Phe Gly Lys Phe Val Gln Tyr Cys Pro Gly Thr Trp Cys Phe
     210                 215                 220                
 Ile Gln Met Val His Glu Glu Gly Ser Leu Ser Val Leu Gly Tyr Ser
 225                 230                 235                 240
 Val Leu Tyr Ser Ser Leu Met Ala Leu Leu Val Leu Ala Thr Val Leu
                 245                 250                 255    
 Cys Asn Leu Gly Ala Met Arg Asn Leu Tyr Ala Met His Arg Arg Leu
             260                 265                 270        
 Gln Arg His Pro Arg Ser Cys Thr Arg Asp Cys Ala Glu Pro Arg Ala
         275                 280                 285            
 Asp Gly Arg Glu Ala Ser Pro Gln Pro Leu Glu Glu Leu Asp His Leu
     290                 295                 300                
 Leu Leu Leu Ala Leu Met Thr Val Leu Phe Thr Met Cys Ser Leu Pro
 305                 310                 315                 320
 Val Ile Tyr Arg Ala Tyr Tyr Gly Ala Phe Lys Asp Val Lys Glu Lys
                 325                 330                 335    
 Asn Arg Thr Ser Glu Glu Ala Glu Asp Leu Arg Ala Leu Arg Phe Leu
             340                 345                 350        
 Ser Val Ile Ser Ile Val Asp Pro Trp Ile Phe Ile Ile Phe Arg Ser
         355                 360                 365            
 Pro Val Phe Arg Ile Phe Phe His Lys Ile Phe Ile Arg Pro Leu Arg
     370                 375                 380                
 Tyr Arg Ser Arg Cys Ser Asn Ser Thr Asn Met Glu Ser Ser Leu
 385                 390                 395                



      <210> 2585
      <211> 382
      <212> PRT
      <213> Homo sapiens

      <220>
      <221> misc_feature
      <222> (1)...(382)
      <223> Xaa = any amino acid or symbol as shown in the table 8 as set forth in Example 2


      <400> 2585
 Cys Ser Glu Ala Glu Tyr Thr Ser Ala Ala Thr Glu Ala Gly Leu Glu
   1               5                  10                  15    
 Leu Val Asp Lys Gly Lys Ala Lys Glu Leu Pro Gly Ser Gln Val Ile
              20                  25                  30        
 Phe Glu Gly Pro Thr Leu Gly Gln Gln Glu Asp Gln Glu Arg Lys Arg
          35                  40                  45            
 Leu Cys Lys Ala Met Thr Leu Cys Ile Cys Tyr Ala Ala Ser Ile Gly
      50                  55                  60                
 Gly Thr Ala Thr Leu Thr Gly Thr Gly Pro Asn Val Val Leu Leu Gly
  65                  70                  75                  80
 Gln Met Asn Glu Leu Phe Pro Asp Ser Lys Asp Leu Val Asn Phe Ala
                  85                  90                  95    
 Ser Trp Phe Ala Phe Ala Phe Pro Asn Met Leu Val Met Leu Leu Phe
             100                 105                 110        
 Ala Trp Leu Trp Leu Gln Phe Val Tyr Met Arg Phe Asn Phe Lys Lys
         115                 120                 125            
 Ser Trp Gly Cys Gly Leu Xaa Ser Lys Lys Asn Glu Lys Ala Ala Leu
     130                 135                 140                
 Lys Val Leu Gln Glu Glu Tyr Arg Lys Leu Gly Pro Leu Ser Phe Ala
 145                 150                 155                 160
 Glu Ile Asn Val Leu Ile Cys Phe Phe Leu Leu Val Ile Leu Trp Phe
                 165                 170                 175    
 Ser Arg Asp Pro Gly Phe Met Pro Gly Trp Leu Thr Val Ala Trp Val
             180                 185                 190        
 Glu Gly Glu Thr Lys Tyr Val Ser Asp Ala Thr Val Ala Ile Phe Val
         195                 200                 205            
 Ala Thr Leu Leu Phe Ile Val Pro Ser Gln Lys Pro Lys Phe Asn Phe
     210                 215                 220                
 Arg Ser Gln Thr Glu Glu Glu Arg Lys Thr Pro Phe Tyr Pro Pro Pro
 225                 230                 235                 240
 Leu Leu Asp Trp Lys Val Thr Gln Glu Lys Val Pro Trp Gly Ile Val
                 245                 250                 255    
 Leu Leu Leu Gly Gly Gly Phe Ala Leu Ala Lys Gly Ser Glu Ala Ser
             260                 265                 270        
 Gly Leu Ser Val Trp Met Gly Lys Gln Met Glu Pro Leu His Ala Val
         275                 280                 285            
 Pro Pro Ala Ala Ile Thr Leu Ile Leu Ser Leu Leu Val Ala Val Phe
     290                 295                 300                
 Thr Glu Cys Thr Ser Asn Val Ala Thr Thr Thr Leu Phe Leu Pro Ile
 305                 310                 315                 320
 Phe Ala Ser Met Ser Arg Ser Ile Gly Leu Asn Pro Leu Tyr Ile Met
                 325                 330                 335    
 Leu Pro Cys Thr Leu Ser Ala Ser Phe Ala Phe Met Leu Pro Val Ala
             340                 345                 350        
 Thr Pro Pro Asn Ala Ile Val Phe Thr Tyr Gly His Leu Lys Val Ala
         355                 360                 365            
 Asp Met Val Thr Gln Leu Phe Leu Phe Thr Pro Val Gly Leu
     370                 375                 380        



      <210> 2586
      <211> 383
      <212> PRT
      <213> Homo sapiens


      <400> 2586
 Glu Leu Ala Arg Arg Pro Lys Gln Gln Ser Ser Glu Lys Ser Arg Asn
   1               5                  10                  15    
 Met Ile Arg Asn Trp Leu Thr Ile Phe Ile Leu Phe Pro Leu Lys Leu
              20                  25                  30        
 Val Glu Lys Cys Glu Ser Ser Val Ser Leu Thr Val Pro Pro Val Val
          35                  40                  45            
 Lys Leu Glu Asn Gly Ser Ser Thr Asn Val Ser Leu Thr Leu Arg Pro
      50                  55                  60                
 Pro Leu Asn Ala Thr Leu Val Ile Thr Phe Glu Ile Thr Phe Arg Ser
  65                  70                  75                  80
 Lys Asn Ile Thr Ile Leu Glu Leu Pro Asp Glu Val Val Val Pro Pro
                  85                  90                  95    
 Gly Val Thr Asn Ser Ser Phe Gln Val Thr Ser Gln Asn Val Gly Gln
             100                 105                 110        
 Leu Thr Val Tyr Leu His Gly Asn His Ser Asn Gln Thr Gly Pro Arg
         115                 120                 125            
 Ile Arg Phe Leu Val Ile Arg Ser Ser Ala Ile Ser Ile Ile Asn Gln
     130                 135                 140                
 Val Ile Gly Trp Ile Tyr Phe Val Ala Trp Ser Ile Ser Phe Tyr Pro
 145                 150                 155                 160
 Gln Val Ile Met Asn Trp Arg Arg Lys Ser Val Ile Gly Leu Ser Phe
                 165                 170                 175    
 Asp Phe Val Ala Leu Asn Leu Thr Gly Phe Val Ala Tyr Ser Val Phe
             180                 185                 190        
 Asn Ile Gly Leu Leu Trp Val Pro Tyr Ile Lys Glu Gln Phe Leu Leu
         195                 200                 205            
 Lys Tyr Pro Asn Gly Val Asn Pro Val Asn Ser Asn Asp Val Phe Phe
     210                 215                 220                
 Ser Leu His Ala Val Val Leu Thr Leu Ile Ile Ile Val Gln Cys Cys
 225                 230                 235                 240
 Leu Tyr Glu Arg Gly Gly Gln Arg Val Ser Trp Pro Ala Ile Gly Phe
                 245                 250                 255    
 Leu Val Leu Ala Trp Leu Phe Ala Phe Val Thr Met Ile Val Ala Ala
             260                 265                 270        
 Val Gly Val Ile Thr Trp Leu Gln Phe Leu Phe Cys Phe Ser Tyr Ile
         275                 280                 285            
 Lys Leu Ala Val Thr Leu Val Lys Tyr Phe Pro Gln Ala Tyr Met Asn
     290                 295                 300                
 Phe Tyr Tyr Lys Ser Thr Glu Gly Trp Ser Ile Gly Asn Val Leu Leu
 305                 310                 315                 320
 Asp Phe Thr Gly Gly Ser Phe Ser Leu Leu Gln Met Phe Leu Gln Ser
                 325                 330                 335    
 Tyr Asn Asn Asp Gln Trp Thr Leu Ile Phe Gly Asp Pro Thr Lys Phe
             340                 345                 350        
 Gly Leu Gly Val Phe Ser Ile Val Phe Asp Val Val Phe Phe Ile Gln
         355                 360                 365            
 His Phe Cys Leu Tyr Arg Lys Arg Pro Gly Tyr Asp Gln Leu Asn
     370                 375                 380            



      <210> 2587
      <211> 131
      <212> PRT
      <213> Homo sapiens


      <400> 2587
 Met Ala Ser Glu Val Val Cys Gly Leu Ile Phe Arg Leu Leu Leu Pro
   1               5                  10                  15    
 Ile Cys Leu Ala Val Ala Cys Ala Phe Arg Tyr Asn Gly Leu Ser Phe
              20                  25                  30        
 Val Tyr Leu Ile Tyr Leu Leu Leu Ile Pro Leu Phe Ser Glu Pro Thr
          35                  40                  45            
 Lys Thr Thr Met Gln Gly His Thr Gly Arg Leu Leu Lys Ser Leu Cys
      50                  55                  60                
 Phe Ile Ser Leu Ser Phe Leu Leu Leu His Ile Ile Phe His Ile Thr
  65                  70                  75                  80
 Leu Val Ser Leu Glu Ala Gln His Arg Ile Ala Pro Gly Tyr Asn Cys
                  85                  90                  95    
 Ser Thr Trp Glu Lys Thr Phe Arg Gln Ile Gly Phe Glu Ser Leu Lys
             100                 105                 110        
 Gly Ala Asp Ala Gly Asn Gly Ile Arg Val Leu Val Pro Asp Ile Gly
         115                 120                 125            
 Met Val Ile
     130    



      <210> 2588
      <211> 271
      <212> PRT
      <213> Homo sapiens


      <400> 2588
 Ile Arg Asn Leu Asn Ser Pro Ala Leu Leu Glu Asp Ser Val Ile Arg
   1               5                  10                  15    
 Gln Ala Lys Ala Ala Gly Lys Arg Ile Val Phe Tyr Gly Asp Glu Thr
              20                  25                  30        
 Trp Val Lys Leu Phe Pro Lys His Phe Val Glu Tyr Asp Gly Thr Thr
          35                  40                  45            
 Ser Phe Phe Val Ser Asp Tyr Thr Glu Val Asp Asn Asn Val Thr Arg
      50                  55                  60                
 His Leu Asp Lys Val Leu Lys Arg Gly Asp Trp Asp Ile Leu Ile Leu
  65                  70                  75                  80
 His Tyr Leu Gly Leu Asp His Ile Gly His Ile Ser Gly Pro Asn Ser
                  85                  90                  95    
 Pro Leu Ile Gly Gln Lys Leu Ser Glu Met Asp Ser Val Leu Met Lys
             100                 105                 110        
 Ile His Thr Ser Leu Gln Ser Lys Glu Arg Glu Thr Pro Leu Pro Asn
         115                 120                 125            
 Leu Leu Val Leu Cys Gly Asp His Gly Met Ser Glu Thr Gly Ser His
     130                 135                 140                
 Gly Ala Ser Ser Thr Glu Glu Gly Asn Thr Pro Leu Ile Leu Ile Ser
 145                 150                 155                 160
 Ser Ala Phe Glu Arg Lys Pro Gly Asp Ile Arg His Pro Lys His Val
                 165                 170                 175    
 Gln Gln Thr Asp Val Ala Ala Thr Leu Ala Ile Ala Leu Gly Leu Pro
             180                 185                 190        
 Ile Pro Lys Asp Ser Val Gly Ser Leu Leu Phe Pro Val Val Glu Gly
         195                 200                 205            
 Arg Pro Met Arg Glu Gln Leu Arg Phe Leu His Leu Asn Thr Val Gln
     210                 215                 220                
 Leu Ile Lys Leu Leu Gln Glu Asn Val Pro Ser Tyr Glu Lys Asp Pro
 225                 230                 235                 240
 Gly Phe Glu Gln Phe Lys Met Ser Lys Arg Leu His Gly Asn Trp Ile
                 245                 250                 255    
 Lys Leu Tyr Leu Glu Glu Lys His Ser Glu Val Leu Phe Asn Leu
             260                 265                 270    



      <210> 2589
      <211> 141
      <212> PRT
      <213> Homo sapiens


      <400> 2589
 Glu Val Arg Val Gln Ala Pro Val Ser Arg Pro Val Leu Thr Leu His
   1               5                  10                  15    
 His Gly Pro Ala Asp Pro Ala Val Gly Asp Met Val Gln Leu Leu Cys
              20                  25                  30        
 Glu Ala Gln Arg Gly Ser Pro Pro Ile Leu Tyr Ser Phe Tyr Leu Asp
          35                  40                  45            
 Glu Lys Ile Val Gly Asn His Ser Ala Pro Cys Gly Gly Thr Thr Ser
      50                  55                  60                
 Leu Leu Phe Pro Val Lys Ser Glu Gln Asp Ala Gly Asn Tyr Ser Cys
  65                  70                  75                  80
 Glu Ala Glu Asn Ser Val Ser Arg Glu Arg Ser Glu Pro Lys Lys Leu
                  85                  90                  95    
 Ser Leu Lys Gly Ser Gln Val Leu Phe Thr Pro Ala Ser Asn Trp Leu
             100                 105                 110        
 Val Pro Trp His Ile Val Gly Thr Ala Leu His Leu Glu Leu Trp Val
         115                 120                 125            
 Val Ser Gly Met Glu Gly Ala Gln Leu Phe Ser Arg Ile
     130                 135                 140    



      <210> 2590
      <211> 121
      <212> PRT
      <213> Homo sapiens


      <400> 2590
 Ser Pro Val Trp Thr Glu Lys Arg Lys Met Gln Asp Thr Gly Ser Val
   1               5                  10                  15    
 Val Pro Leu His Trp Phe Gly Phe Gly Tyr Ala Ala Leu Val Ala Ser
              20                  25                  30        
 Gly Gly Ile Ile Gly Tyr Val Lys Ala Gly Ser Val Pro Ser Leu Ala
          35                  40                  45            
 Ala Gly Leu Leu Phe Gly Ser Leu Ala Gly Leu Gly Ala Tyr Gln Leu
      50                  55                  60                
 Ser Gln Asp Pro Arg Asn Val Trp Val Phe Leu Ala Thr Ser Gly Thr
  65                  70                  75                  80
 Leu Ala Gly Ile Met Gly Met Arg Phe Tyr His Ser Gly Lys Phe Met
                  85                  90                  95    
 Pro Ala Gly Leu Ile Ala Gly Ala Ser Leu Leu Met Val Ala Lys Val
             100                 105                 110        
 Gly Val Ser Met Phe Asn Arg Pro His
         115                 120    



      <210> 2591
      <211> 339
      <212> PRT
      <213> Homo sapiens


      <400> 2591
 Met Gly Leu Gly Pro Val Phe Leu Leu Leu Ala Gly Ile Phe Pro Phe
   1               5                  10                  15    
 Ala Pro Pro Gly Ala Ala Ala Glu Pro His Ser Leu Arg Tyr Asn Leu
              20                  25                  30        
 Thr Val Leu Ser Trp Asp Gly Ser Val Gln Ser Gly Phe Leu Ala Glu
          35                  40                  45            
 Val His Leu Asp Gly Gln Pro Phe Leu Arg Tyr Asp Arg Gln Lys Cys
      50                  55                  60                
 Arg Ala Lys Pro Gln Gly Gln Trp Ala Glu Asp Val Leu Gly Asn Lys
  65                  70                  75                  80
 Thr Trp Asp Arg Glu Thr Arg Asp Leu Thr Gly Asn Gly Lys Asp Leu
                  85                  90                  95    
 Arg Met Thr Leu Ala His Ile Lys Asp Gln Lys Glu Gly Leu His Ser
             100                 105                 110        
 Leu Gln Glu Ile Arg Val Cys Glu Ile His Glu Asp Asn Ser Thr Arg
         115                 120                 125            
 Ser Ser Gln His Phe Tyr Tyr Asp Gly Glu Leu Phe Leu Ser Gln Asn
     130                 135                 140                
 Leu Glu Thr Glu Glu Trp Thr Val Pro Gln Ser Ser Arg Ala Gln Thr
 145                 150                 155                 160
 Leu Ala Met Asn Val Arg Asn Phe Leu Lys Glu Asp Ala Met Lys Thr
                 165                 170                 175    
 Lys Thr His Tyr His Ala Met His Ala Asp Cys Leu Gln Glu Leu Arg
             180                 185                 190        
 Arg Tyr Leu Glu Ser Gly Val Val Leu Arg Arg Thr Val Pro Pro Met
         195                 200                 205            
 Val Asn Val Thr Arg Ser Glu Ala Ser Glu Gly Asn Ile Thr Val Thr
     210                 215                 220                
 Cys Arg Ala Ser Ser Phe Tyr Pro Arg Asn Ile Ile Leu Thr Trp Arg
 225                 230                 235                 240
 Gln Asp Gly Val Ser Leu Ser His Asp Thr Gln Gln Trp Gly Asp Val
                 245                 250                 255    
 Leu Pro Asp Gly Asn Gly Thr Tyr Gln Thr Trp Val Ala Thr Arg Ile
             260                 265                 270        
 Cys Arg Gly Glu Glu Gln Arg Phe Thr Cys Tyr Met Glu His Ser Gly
         275                 280                 285            
 Asn His Ser Thr His Pro Val Pro Ser Glu Leu Val Ser Leu Gln Val
     290                 295                 300                
 Leu Asp Gln His Pro Val Gly Thr Ser Asp His Arg Asp Ala Thr Gln
 305                 310                 315                 320
 Leu Gly Phe Gln Pro Leu Met Ser Ala Leu Gly Ser Thr Gly Ser Thr
                 325                 330                 335    
 Glu Gly Thr
            



      <210> 2592
      <211> 153
      <212> PRT
      <213> Homo sapiens


      <400> 2592
 Glu Phe Gln Glu Ala Ala Lys Leu Tyr His Thr Asn Tyr Val Arg Asn
   1               5                  10                  15    
 Ser Arg Ala Ile Gly Val Leu Trp Ala Ile Phe Thr Ile Cys Phe Ala
              20                  25                  30        
 Ile Val Asn Val Val Cys Phe Ile Gln Pro Tyr Trp Ile Gly Asp Gly
          35                  40                  45            
 Val Asp Thr Pro Gln Ala Gly Tyr Phe Gly Leu Phe His Tyr Cys Ile
      50                  55                  60                
 Gly Asn Gly Phe Ser Arg Glu Leu Thr Cys Arg Gly Ser Phe Thr Asp
  65                  70                  75                  80
 Phe Ser Thr Leu Pro Ser Gly Ala Phe Lys Ala Ala Ser Phe Phe Ile
                  85                  90                  95    
 Gly Leu Ser Met Met Leu Ile Ile Ala Cys Ile Ile Cys Phe Thr Leu
             100                 105                 110        
 Phe Phe Phe Cys Asn Thr Ala Thr Val Tyr Lys Ile Cys Ala Trp Met
         115                 120                 125            
 Gln Leu Thr Ser Ala Ala Cys Leu Val Leu Gly Cys Met Ile Phe Pro
     130                 135                 140                
 Asp Gly Trp Asp Ser Asp Glu Val Asn
 145                 150            



      <210> 2593
      <211> 333
      <212> PRT
      <213> Homo sapiens


      <400> 2593
 Ala Trp His Glu Gly Leu Val Ser Ser Pro Ala Ile Gly Ala Tyr Leu
   1               5                  10                  15    
 Ser Ala Ser Tyr Gly Asp Ser Leu Val Val Leu Val Ala Thr Val Val
              20                  25                  30        
 Ala Leu Leu Asp Ile Cys Phe Ile Leu Val Ala Val Pro Glu Ser Leu
          35                  40                  45            
 Pro Glu Lys Met Arg Pro Val Ser Trp Gly Ala Gln Ile Ser Trp Lys
      50                  55                  60                
 Gln Ala Asp Pro Phe Ala Ser Leu Lys Lys Val Gly Lys Asp Ser Thr
  65                  70                  75                  80
 Val Leu Leu Ile Cys Ile Thr Val Cys Leu Ser Tyr Leu Pro Glu Ala
                  85                  90                  95    
 Gly Gln Tyr Ser Ser Phe Phe Leu Tyr Leu Arg Gln Val Ile Gly Phe
             100                 105                 110        
 Gly Thr Val Lys Ile Ala Ala Phe Ile Ala Met Val Gly Ile Leu Ser
         115                 120                 125            
 Ile Val Ala Gln Thr Ala Phe Leu Ser Ile Leu Met Arg Ser Leu Gly
     130                 135                 140                
 Asn Lys Asn Thr Val Leu Leu Gly Leu Gly Phe Gln Met Leu Gln Leu
 145                 150                 155                 160
 Ala Trp Tyr Gly Phe Gly Ser Gln Ala Trp Met Met Trp Ala Ala Gly
                 165                 170                 175    
 Thr Val Ala Ala Met Ser Ser Ile Thr Phe Pro Ala Ile Ser Ala Leu
             180                 185                 190        
 Val Ser Arg Asn Ala Glu Ser Asp Gln Gln Gly Val Ala Gln Gly Ile
         195                 200                 205            
 Ile Thr Gly Ile Arg Gly Leu Cys Asn Gly Leu Gly Pro Ala Leu Tyr
     210                 215                 220                
 Gly Phe Ile Phe Tyr Met Phe His Val Glu Leu Thr Glu Leu Gly Pro
 225                 230                 235                 240
 Lys Leu Asn Ser Asn Asn Val Pro Leu Gln Gly Ala Val Ile Pro Gly
                 245                 250                 255    
 Pro Pro Phe Leu Phe Gly Ala Cys Ile Val Leu Met Ser Phe Leu Ala
             260                 265                 270        
 Ala Leu Phe Ile Pro Glu Tyr Ser Lys Ala Ser Gly Val Gln Lys His
         275                 280                 285            
 Ser Asn Ser Ser Ser Gly Ser Leu Thr Asn Thr Pro Glu Arg Gly Ser
     290                 295                 300                
 Asp Glu Asp Ile Glu Pro Leu Leu Gln Asp Ser Ser Ile Trp Glu Leu
 305                 310                 315                 320
 Ser Ser Phe Glu Glu Pro Gly Asn Gln Cys Thr Glu Leu
                 325                 330            



      <210> 2594
      <211> 333
      <212> PRT
      <213> Homo sapiens


      <400> 2594
 Ala Trp His Glu Gly Leu Val Ser Ser Pro Ala Ile Gly Ala Tyr Leu
   1               5                  10                  15    
 Ser Ala Ser Tyr Gly Asp Ser Leu Val Val Leu Val Ala Thr Val Val
              20                  25                  30        
 Ala Leu Leu Asp Ile Cys Phe Ile Leu Val Ala Val Pro Glu Ser Leu
          35                  40                  45            
 Pro Glu Lys Met Arg Pro Val Ser Trp Gly Ala Gln Ile Ser Trp Lys
      50                  55                  60                
 Gln Ala Asp Pro Phe Ala Ser Leu Lys Lys Val Gly Lys Asp Ser Thr
  65                  70                  75                  80
 Val Leu Leu Ile Cys Ile Thr Val Cys Leu Ser Tyr Leu Pro Glu Ala
                  85                  90                  95    
 Gly Gln Tyr Ser Ser Phe Phe Leu Tyr Leu Arg Gln Val Ile Gly Phe
             100                 105                 110        
 Gly Thr Val Lys Ile Ala Ala Phe Ile Ala Met Val Gly Ile Leu Ser
         115                 120                 125            
 Ile Val Ala Gln Thr Ala Phe Leu Ser Ile Leu Met Arg Ser Leu Gly
     130                 135                 140                
 Asn Lys Asn Thr Val Leu Leu Gly Leu Gly Phe Gln Met Leu Gln Leu
 145                 150                 155                 160
 Ala Trp Tyr Gly Phe Gly Ser Gln Ala Trp Met Met Trp Ala Ala Gly
                 165                 170                 175    
 Thr Val Ala Ala Met Ser Ser Ile Thr Phe Pro Ala Ile Ser Ala Leu
             180                 185                 190        
 Val Ser Arg Asn Ala Glu Ser Asp Gln Gln Gly Val Ala Gln Gly Ile
         195                 200                 205            
 Ile Thr Gly Ile Arg Gly Leu Cys Asn Gly Leu Gly Pro Ala Leu Tyr
     210                 215                 220                
 Gly Phe Ile Phe Tyr Met Phe His Val Glu Leu Thr Glu Leu Gly Pro
 225                 230                 235                 240
 Lys Leu Asn Ser Asn Asn Val Pro Leu Gln Gly Ala Val Ile Pro Gly
                 245                 250                 255    
 Pro Pro Phe Leu Phe Gly Ala Cys Ile Val Leu Met Ser Phe Leu Ala
             260                 265                 270        
 Ala Leu Phe Ile Pro Glu Tyr Ser Lys Ala Ser Gly Val Gln Lys His
         275                 280                 285            
 Ser Asn Ser Ser Ser Gly Ser Leu Thr Asn Thr Pro Glu Arg Gly Ser
     290                 295                 300                
 Asp Glu Asp Ile Glu Pro Leu Leu Gln Asp Ser Ser Ile Trp Glu Leu
 305                 310                 315                 320
 Ser Ser Phe Glu Glu Pro Gly Asn Gln Cys Thr Glu Leu
                 325                 330            



      <210> 2595
      <211> 511
      <212> PRT
      <213> Homo sapiens

      <220>
      <221> misc_feature
      <222> (1)...(511)
      <223> Xaa = any amino acid or symbol as shown in the table 8 as set forth in Example 2


      <400> 2595
 Lys Gln Pro Ser Gly Leu Leu Lys Phe Gly Asn Leu Ile Leu Lys Cys
   1               5                  10                  15    
 His Pro Pro Ser Leu Thr His Met Leu Ser Gln Pro Cys Ala Glu Ala
              20                  25                  30        
 Pro Thr Pro Asp Pro Asn Trp Glu Leu Ala Leu Tyr Ile His Pro Ser
          35                  40                  45            
 Ser Gly Ile Met Ser Ala Thr Val Ser Phe Trp Ser Ile Gly Thr Ala
      50                  55                  60                
 Tyr Leu Glu Ala Gln Gly Ile Trp Glu Pro Phe Arg Arg Arg Leu Ser
  65                  70                  75                  80
 Phe Glu Ala Ser Asn Pro Pro Phe Asp Val Gly Arg Pro Phe Asp Leu
                  85                  90                  95    
 Arg Arg Ile Val Gly Ile Ser Ser Glu Gly Asn Leu Asn Thr Leu Ser
             100                 105                 110        
 Cys Asp Pro Gly His Ser Arg Gly Phe Cys Gly Ala Gly Gly Ser Ser
         115                 120                 125            
 Ser Arg Pro Ser Ala Gly Ser His Lys Gln Xaa Gly Pro Ser Gly His
     130                 135                 140                
 Pro His Ser Ser His Ser Asn Arg Asn Ser Ala Asp Val Asp Asp Val
 145                 150                 155                 160
 Arg Ala Tyr Asn Ser Gly Arg Thr Ser Ser Met Thr Ser Ala Gln Ala
                 165                 170                 175    
 Ala Ser Ser Gln Pro Ala Asn Lys Thr Arg Pro Leu Val Leu Asp Ser
             180                 185                 190        
 Asn Thr Gly Ala Gln Gly His Ser Ala Gly Arg Lys Ser Lys Gly Ala
         195                 200                 205            
 Lys Gln Ser Gln His Gly Ser Gln His His Ala His Ser Pro Leu Glu
     210                 215                 220                
 Gln His Pro Gln Pro Pro Leu Pro Pro Pro Val Pro Gln Pro Gln Glu
 225                 230                 235                 240
 Pro Gln Pro Glu Arg Leu Ser Pro Ala Pro Leu Ala His Pro Ser His
                 245                 250                 255    
 Pro Glu Arg Ala Ser Ser Ala Arg His Ser Ser Glu Asp Ser Asp Ile
             260                 265                 270        
 Thr Ser Leu Ile Glu Ala Met Asp Lys Asp Phe Asp His His Asp Ser
         275                 280                 285            
 Pro Ala Leu Glu Val Phe Thr Glu Gln Pro Pro Ser Pro Leu Pro Lys
     290                 295                 300                
 Ser Lys Gly Ser Thr Glu Gly Gly Pro Ala Ser Thr Phe Thr Gln Ala
 305                 310                 315                 320
 Val Asp Gly Gly Ile Gln Phe Phe Thr Asp Cys Trp Thr Glu Gly Pro
                 325                 330                 335    
 Ser Ser Ser Leu Leu Ala Val Ala Arg Glu Val Gln Leu Ala Leu Cys
             340                 345                 350        
 Ile His Glu Leu Leu Ile His Gly Phe Ser Gln Leu Gln Val Ser Gly
         355                 360                 365            
 Gly Pro Gly Ala Met Pro Asp Pro Ala Ala His Leu Pro Phe Phe Tyr
     370                 375                 380                
 Gly Ser Ile Ser Arg Ala Glu Ala Glu Glu His Leu Lys Leu Ala Gly
 385                 390                 395                 400
 Met Ala Asp Gly Leu Phe Leu Val Arg Gln Cys Leu Arg Ser Leu Gly
                 405                 410                 415    
 Gly Tyr Arg Gln Leu Asn Gly Thr Tyr Ala Ile Ala Gly Gly Lys Ala
             420                 425                 430        
 His Cys Gly Pro Ala Glu Leu Cys Glu Phe Tyr Ser Arg Asp Pro Asp
         435                 440                 445            
 Gly Leu Pro Cys Asn Leu Arg Lys Pro Cys Ile Pro Pro Ser Gly Leu
     450                 455                 460                
 Glu Pro Gln Pro Gly Ser Ser Thr Ala Cys Glu Thr Pro Trp Ala Arg
 465                 470                 475                 480
 Pro Arg Ser Arg Pro Ser Ser Ala Arg Pro Arg Arg Trp Arg Ser Ser
                 485                 490                 495    
 Leu Leu Arg Arg Thr Thr Ser Gly Cys Pro Gly Thr Thr Ala Ala
             500                 505                 510    



      <210> 2596
      <211> 200
      <212> PRT
      <213> Homo sapiens


      <400> 2596
 Pro Leu Gly Val Asn Gly Leu Ala Phe Leu Ile Met Val Phe Leu Ile
   1               5                  10                  15    
 Gly Val Cys Cys Val Pro Phe Lys Glu Pro Ala Leu Gln Pro Thr Glu
              20                  25                  30        
 Val Arg Asn Cys Phe Gly Arg Glu Val Ala Val Ala Asn Arg Phe Phe
          35                  40                  45            
 Phe Ile Val Phe Ser Asp Ala Ile Cys Trp Ile Pro Val Phe Val Val
      50                  55                  60                
 Lys Ile Leu Ser Leu Phe Arg Val Glu Ile Pro Gly Gln Ser Leu Leu
  65                  70                  75                  80
 Ser Phe Pro Ser Ile Ile His Arg Ala Phe Leu Arg Pro Ser Phe Asp
                  85                  90                  95    
 Lys Ala Arg Val Phe Gln Arg Asn Ile Ser Leu Asn Tyr His Pro Cys
             100                 105                 110        
 Met Lys Ile Pro Ser Gln Glu Leu Arg Asn Pro Gly Glu Arg Leu Trp
         115                 120                 125            
 His Leu Ser Ser Arg Thr Pro Ser Thr Tyr Gly Gly Ser Arg Thr Ala
     130                 135                 140                
 Pro Glu Pro Gly Pro Cys Leu Met Asp Gln Gly Ile Arg His Lys Ser
 145                 150                 155                 160
 Pro Leu Ile Ser His Gln Gly Ser Leu Pro Lys Asp Ser Ser Ser Lys
                 165                 170                 175    
 Pro Ala His Arg Pro Arg Gln Leu Phe Gln Pro Glu Ser Leu Asn Arg
             180                 185                 190        
 Gln Ile Val Thr Gly Phe Pro Cys
         195                 200



      <210> 2597
      <211> 118
      <212> PRT
      <213> Homo sapiens


      <400> 2597
 Pro Gly Pro Gly Met Gln Gly Pro Pro Pro Ile Thr Pro Thr Ser Trp
   1               5                  10                  15    
 Ser Leu Pro Pro Trp Arg Ala Tyr Val Ala Ala Ala Val Leu Cys Tyr
              20                  25                  30        
 Ile Asn Leu Leu Asn Tyr Met Asn Trp Phe Ile Ile Ala Gly Val Leu
          35                  40                  45            
 Leu Asp Ile Gln Glu Val Phe Gln Ile Ser Asp Asn His Ala Gly Leu
      50                  55                  60                
 Leu Gln Thr Val Phe Val Ser Cys Leu Leu Leu Ser Ala Pro Val Phe
  65                  70                  75                  80
 Gly Tyr Leu Gly Asp Arg His Ser Arg Lys Ala Thr Met Ser Phe Gly
                  85                  90                  95    
 Ile Leu Leu Trp Ser Gly Ala Gly Leu Ser Ser Ser Phe Ile Ser Pro
             100                 105                 110        
 Arg Tyr Ser Trp Leu Phe
         115            



      <210> 2598
      <211> 325
      <212> PRT
      <213> Homo sapiens


      <400> 2598
 Lys Met Thr Ser Leu Ala Gln Gln Leu Gln Arg Leu Ala Leu Pro Gln
   1               5                  10                  15    
 Ser Asp Ala Ser Leu Leu Ser Arg Asp Glu Val Ala Ser Leu Leu Phe
              20                  25                  30        
 Asp Pro Lys Glu Ala Ala Thr Ile Asp Arg Asp Thr Ala Phe Ala Ile
          35                  40                  45            
 Gly Cys Thr Gly Leu Glu Glu Leu Leu Gly Ile Asp Pro Ser Phe Glu
      50                  55                  60                
 Gln Phe Glu Ala Pro Leu Phe Ser Gln Leu Ala Lys Thr Leu Glu Arg
  65                  70                  75                  80
 Ser Val Gln Thr Lys Ala Val Asn Lys Gln Leu Asp Glu Asn Ile Ser
                  85                  90                  95    
 Leu Phe Leu Ile His Leu Ser Pro Tyr Phe Leu Leu Lys Pro Ala Gln
             100                 105                 110        
 Lys Cys Leu Glu Trp Leu Ile His Arg Phe His Ile His Leu Tyr Asn
         115                 120                 125            
 Gln Asp Ser Leu Ile Ala Cys Val Leu Pro Tyr His Glu Thr Arg Ile
     130                 135                 140                
 Phe Val Arg Val Ile Gln Leu Leu Lys Ile Asn Asn Ser Lys His Arg
 145                 150                 155                 160
 Trp Phe Trp Leu Leu Pro Val Lys Gln Ser Gly Val Pro Leu Ala Lys
                 165                 170                 175    
 Gly Thr Leu Ile Thr His Cys Tyr Lys Asp Leu Gly Phe Met Asp Phe
             180                 185                 190        
 Ile Cys Ser Leu Val Thr Lys Ser Val Lys Val Phe Ala Glu Tyr Pro
         195                 200                 205            
 Gly Ser Ser Ala Gln Leu Arg Val Leu Leu Ala Phe Tyr Ala Ser Thr
     210                 215                 220                
 Ile Val Ser Ala Leu Val Ala Ala Glu Asp Val Ser Asp Asn Ile Ile
 225                 230                 235                 240
 Ala Lys Leu Phe Ser Tyr Ile Gln Lys Gly Leu Lys Ser Ser Leu Pro
                 245                 250                 255    
 Asp Tyr Arg Ala Ala Thr Tyr Met Ile Ile Cys Gln Ile Ser Val Lys
             260                 265                 270        
 Val Thr Met Glu Asn Thr Phe Val Asn Ser Leu Ala Ser Gln Ile Ile
         275                 280                 285            
 Lys Thr Leu Thr Lys Ile Pro Ser Leu Ile Lys Asp Gly Leu Ser Cys
     290                 295                 300                
 Leu Ile Val Leu Leu Gln Arg Gln Lys Pro Glu Ser Leu Gly Lys Lys
 305                 310                 315                 320
 Tyr Val Gln Leu Asn
                 325



      <210> 2599
      <211> 241
      <212> PRT
      <213> Homo sapiens

      <220>
      <221> misc_feature
      <222> (1)...(241)
      <223> Xaa = any amino acid or symbol as shown in the table 8 as set forth in Example 2


      <400> 2599
 Val Glu Val Pro Ser Ala Val Pro Arg Pro Thr Leu Asp Thr Ser Arg
   1               5                  10                  15    
 Ala Ala Thr Cys Ala Pro Gly His Ala Val His His Pro Gln Ser Leu
              20                  25                  30        
 Ser Trp Pro Arg Thr Ala Gly Thr Val Gly Gly Ser Pro Ala Leu Arg
          35                  40                  45            
 Gly Ala His Pro Xaa Pro Leu Pro Thr Val Pro Ala Asp Cys Cys Glu
      50                  55                  60                
 Pro Xaa Glu Gln Cys Pro Gly Arg Arg Gly Gln Gln Arg Leu Cys Ala
  65                  70                  75                  80
 Pro Ser His Leu Leu Ala Gln Leu Leu Leu Trp Leu Cys Thr Pro Val
                  85                  90                  95    
 Pro Lys His Trp Gly Ser Ala Gln Gln Pro Gly Gly Gln Val Tyr His
             100                 105                 110        
 Xaa Cys Leu Gly Leu Pro Pro His Pro Pro Trp Gln Pro Gly Xaa His
         115                 120                 125            
 Arg Gly Xaa Cys Val Gly Ala Cys Gly Phe Arg Asp Pro Xaa Cys Gly
     130                 135                 140                
 Gln Gly His Asp Ser His Pro Thr Gln Ala Ser Gly Ser Lys Ala Pro
 145                 150                 155                 160
 Tyr Pro Gly Pro Ala Pro Ala Ser Gly Ser Ala Arg Thr Asn Arg Ala
                 165                 170                 175    
 Ser Gln His Leu Trp Pro Arg Asp Pro Ala Pro Gly Gly Ser Pro His
             180                 185                 190        
 Arg Ala Arg Pro Cys Leu Gln Cys Pro Pro Cys Leu Leu Pro Leu Pro
         195                 200                 205            
 Gly Val Leu Thr Gly Trp Gly Trp Val Trp Gln Lys Ala Glu Leu Phe
     210                 215                 220                
 Glu Ala Trp Gly Gln Glu Gln Ser Arg His Ser Ser Asn Gly Val Cys
 225                 230                 235                 240
 Thr
    



      <210> 2600
      <211> 1347
      <212> PRT
      <213> Homo sapiens


      <400> 2600
 Ser Ser Asn Ser Gln Leu Tyr Arg Ala Ser Ala Leu Phe Glu Thr Ile
   1               5                  10                  15    
 Arg His Glu Ala Gln Leu Ser Thr Asp Tyr Lys Leu Ser Leu Phe Asp
              20                  25                  30        
 Leu Gln Thr Ser Ser Tyr Gln Ala Leu Gln Arg Val Leu Val Ser Leu
          35                  40                  45            
 Gly His His Asp Glu Ala Leu Ala Val Ala Glu Arg Gly Arg Thr Arg
      50                  55                  60                
 Ala Phe Ala Asp Leu Leu Val Glu Arg Gln Thr Gly Gln Gln Asp Ser
  65                  70                  75                  80
 Asp Pro Tyr Ser Pro Val Thr Ile Asp Gln Ile Leu Glu Met Val Asn
                  85                  90                  95    
 Gly Gln Arg Gly Leu Val Leu Tyr Tyr Ser Leu Ala Ala Gly Tyr Leu
             100                 105                 110        
 Tyr Ser Trp Leu Leu Ala Pro Gly Ala Gly Ile Val Lys Phe His Glu
         115                 120                 125            
 His Tyr Leu Gly Glu Asn Thr Val Glu Asn Ser Ser Asp Phe Gln Ala
     130                 135                 140                
 Ser Ser Ser Val Thr Leu Pro Thr Ala Thr Gly Ser Ala Leu Glu Gln
 145                 150                 155                 160
 His Ile Ala Ser Val Arg Glu Ala Leu Gly Val Glu Ser His Tyr Ser
                 165                 170                 175    
 Arg Ala Cys Ala Ser Ser Glu Thr Glu Ser Glu Ala Gly Asp Ile Met
             180                 185                 190        
 Asp Gln Gln Phe Glu Glu Met Asn Asn Lys Leu Asn Ser Val Thr Asp
         195                 200                 205            
 Pro Thr Gly Phe Leu Arg Met Val Arg Arg Asn Asn Leu Phe Asn Arg
     210                 215                 220                
 Ser Cys Gln Ser Met Thr Ser Leu Phe Ser Asn Thr Val Ser Pro Thr
 225                 230                 235                 240
 Gln Asp Gly Thr Ser Ser Leu Pro Arg Arg Gln Ser Ser Phe Ala Lys
                 245                 250                 255    
 Pro Pro Leu Arg Ala Leu Tyr Asp Leu Leu Ile Ala Pro Met Glu Gly
             260                 265                 270        
 Gly Leu Met His Ser Ser Gly Pro Val Gly Arg His Arg Gln Leu Ile
         275                 280                 285            
 Leu Val Leu Glu Gly Glu Leu Tyr Leu Ile Pro Phe Ala Leu Leu Lys
     290                 295                 300                
 Gly Ser Ser Ser Asn Glu Tyr Leu Tyr Glu Arg Phe Gly Leu Leu Ala
 305                 310                 315                 320
 Val Pro Ser Ile Arg Ser Leu Ser Val Gln Ser Lys Ser His Leu Arg
                 325                 330                 335    
 Lys Asn Pro Pro Thr Tyr Ser Ser Ser Thr Ser Met Ala Ala Val Ile
             340                 345                 350        
 Gly Asn Pro Lys Leu Pro Ser Ala Val Met Asp Arg Trp Leu Trp Gly
         355                 360                 365            
 Pro Met Pro Ser Ala Glu Glu Glu Ala Tyr Met Val Ser Glu Leu Leu
     370                 375                 380                
 Gly Cys Gln Pro Leu Val Gly Ser Val Ala Thr Lys Glu Arg Val Met
 385                 390                 395                 400
 Ser Ala Leu Thr Gln Ala Glu Cys Val His Phe Ala Thr His Ile Ser
                 405                 410                 415    
 Trp Lys Leu Ser Ala Leu Val Leu Thr Pro Ser Met Asp Gly Asn Pro
             420                 425                 430        
 Ala Ser Ser Lys Ser Ser Phe Gly His Pro Tyr Thr Ile Pro Glu Ser
         435                 440                 445            
 Leu Arg Val Gln Asp Asp Ala Ser Asp Gly Glu Ser Ile Ser Asp Cys
     450                 455                 460                
 Pro Pro Leu Gln Glu Leu Leu Leu Thr Ala Ala Asp Val Leu Asp Leu
 465                 470                 475                 480
 Gln Leu Pro Val Lys Leu Val Val Leu Gly Ser Ser Gln Glu Ser Asn
                 485                 490                 495    
 Ser Lys Val Ala Ala Asp Gly Val Ile Ala Leu Thr Arg Ala Phe Leu
             500                 505                 510        
 Ala Ala Gly Ala Gln Cys Val Leu Val Ser Leu Trp Pro Val Pro Val
         515                 520                 525            
 Ala Ala Phe Lys Met Phe Ile His Ala Phe Tyr Ser Ser Leu Leu Asn
     530                 535                 540                
 Gly Leu Lys Ala Ser Ala Ala Leu Gly Glu Ala Met Lys Val Val Gln
 545                 550                 555                 560
 Ser Ser Lys Ala Phe Ser His Pro Ser Asn Trp Ala Gly Phe Met Leu
                 565                 570                 575    
 Ile Gly Ser Asp Val Lys Leu Asn Ser Pro Ser Ser Leu Ile Gly Gln
             580                 585                 590        
 Ala Leu Thr Glu Ile Leu Gln His Pro Glu Arg Ala Arg Asp Ala Leu
         595                 600                 605            
 Arg Val Leu Leu His Leu Val Glu Lys Ser Leu Gln Arg Ile Gln Asn
     610                 615                 620                
 Gly Gln Arg Asn Ala Met Tyr Thr Ser Gln Gln Ser Val Glu Asn Lys
 625                 630                 635                 640
 Val Gly Gly Ile Pro Gly Trp Gln Ala Leu Leu Thr Ala Val Gly Phe
                 645                 650                 655    
 Arg Leu Asp Pro Pro Thr Ser Gly Leu Pro Ala Ala Val Phe Phe Pro
             660                 665                 670        
 Thr Ser Asp Pro Gly Asp Arg Leu Gln Gln Cys Ser Ser Thr Leu Gln
         675                 680                 685            
 Ser Leu Leu Gly Leu Pro Asn Pro Ala Leu Gln Ala Leu Cys Lys Leu
     690                 695                 700                
 Ile Thr Ala Ser Glu Thr Gly Glu Gln Leu Ile Ser Arg Ala Val Lys
 705                 710                 715                 720
 Asn Met Val Gly Met Leu His Gln Val Leu Val Gln Leu Gln Ala Gly
                 725                 730                 735    
 Glu Lys Glu Gln Asp Leu Ala Ser Ala Pro Ile Gln Val Ser Ile Ser
             740                 745                 750        
 Val Gln Leu Trp Arg Leu Pro Gly Cys His Glu Phe Leu Ala Ala Leu
         755                 760                 765            
 Gly Phe Asp Leu Cys Glu Val Gly Gln Glu Glu Val Ile Leu Lys Thr
     770                 775                 780                
 Gly Lys Gln Ala Asn Arg Arg Thr Val His Phe Ala Leu Gln Ser Leu
 785                 790                 795                 800
 Leu Ser Leu Phe Asp Ser Thr Glu Leu Pro Lys Arg Leu Ser Leu Asp
                 805                 810                 815    
 Ser Ser Ser Ser Leu Glu Ser Leu Ala Ser Ala Gln Ser Val Ser Asn
             820                 825                 830        
 Ala Leu Pro Leu Gly Tyr Gln Gln Pro Pro Phe Ser Pro Thr Gly Ala
         835                 840                 845            
 Asp Ser Ile Ala Ser Asp Ala Ile Ser Val Tyr Ser Leu Ser Ser Ile
     850                 855                 860                
 Ala Ser Ser Met Ser Phe Val Ser Lys Pro Glu Gly Gly Ser Glu Gly
 865                 870                 875                 880
 Gly Gly Pro Gly Gly Arg Gln Asp His Asp Arg Ser Lys Asn Ala Tyr
                 885                 890                 895    
 Leu Gln Arg Ser Thr Leu Pro Arg Ser Gln Leu Pro Pro Gln Thr Arg
             900                 905                 910        
 Pro Ala Gly Asn Lys Asp Glu Glu Glu Tyr Glu Gly Phe Ser Ile Ile
         915                 920                 925            
 Ser Asn Glu Pro Leu Ala Thr Tyr Gln Glu Asn Arg Asn Thr Cys Phe
     930                 935                 940                
 Ser Pro Asp His Lys Gln Pro Gln Pro Gly Thr Ala Gly Gly Met Arg
 945                 950                 955                 960
 Val Ser Val Ser Ser Lys Gly Ser Ile Ser Thr Pro Asn Ser Pro Val
                 965                 970                 975    
 Lys Met Thr Leu Ile Pro Ser Pro Asn Ser Pro Phe Gln Lys Val Gly
             980                 985                 990        
 Lys Leu Ala Ser Ser Asp Thr Gly Glu Ser Asp Gln Ser Ser Thr Glu
         995                1000                1005            
 Thr Asp Ser Thr Val Lys Ser Gln Glu Glu Ser Asn Pro Lys Leu Asp
    1010                1015                1020                
 Pro Gln Glu Leu Ala Gln Lys Ile Leu Glu Glu Thr Gln Ser His Leu
1025                1030                1035                1040
 Ile Ala Val Glu Arg Leu Gln Arg Ser Gly Gly Gln Val Ser Lys Ser
                1045                1050                1055    
 Asn Asn Pro Glu Asp Gly Val Gln Ala Pro Ser Ser Thr Ala Val Phe
            1060                1065                1070        
 Arg Ala Ser Glu Thr Ser Ala Phe Ser Arg Pro Val Leu Ser His Gln
        1075                1080                1085            
 Lys Ser Gln Pro Ser Pro Val Thr Val Lys Pro Lys Pro Pro Ala Arg
    1090                1095                1100                
 Ser Ser Ser Leu Pro Lys Val Ser Ser Gly Tyr Ser Ser Pro Thr Thr
1105                1110                1115                1120
 Ser Glu Met Ser Ile Lys Asp Ser Pro Ser Gln His Ser Gly Arg Pro
                1125                1130                1135    
 Ser Pro Gly Cys Asp Ser Gln Thr Ser Gln Leu Asp Gln Pro Leu Phe
            1140                1145                1150        
 Lys Leu Lys Tyr Pro Ser Ser Pro Tyr Ser Ala His Ile Ser Lys Ser
        1155                1160                1165            
 Pro Arg Asn Met Ser Pro Ser Ser Gly His Gln Ser Pro Ala Gly Ser
    1170                1175                1180                
 Ala Pro Ser Pro Ala Leu Ser Tyr Ser Ser Ala Gly Ser Ala Arg Ser
1185                1190                1195                1200
 Ser Pro Ala Asp Ala Pro Asp Ile Asp Lys Leu Lys Met Ala Ala Ile
                1205                1210                1215    
 Asp Glu Lys Val Gln Ala Val His Asn Leu Lys Met Phe Trp Gln Ser
            1220                1225                1230        
 Thr Pro Gln His Ser Thr Gly Pro Met Lys Ile Phe Arg Gly Ala Pro
        1235                1240                1245            
 Gly Thr Met Thr Ser Lys Arg Asp Val Leu Ser Leu Leu Asn Leu Ser
    1250                1255                1260                
 Pro Arg Pro Asn Lys Lys Glu Glu Gly Val Asp Lys Leu Glu Leu Lys
1265                1270                1275                1280
 Glu Leu Ser Leu Gln Gln His Asp Gly Ala Pro Pro Lys Ala Pro Pro
                1285                1290                1295    
 Asn Gly His Trp Arg Thr Glu Thr Thr Ser Leu Gly Ser Leu Pro Leu
            1300                1305                1310        
 Pro Ala Gly Pro Pro Ala Thr Ala Pro Ala Arg Pro Leu Arg Leu Pro
        1315                1320                1325            
 Ser Gly Asn Gly Tyr Lys Phe Leu Ser Pro Gly Arg Phe Phe Pro Ser
    1330                1335                1340                
 Ser Lys Cys
1345        



      <210> 2601
      <211> 266
      <212> PRT
      <213> Homo sapiens

      <220>
      <221> misc_feature
      <222> (1)...(266)
      <223> Xaa = any amino acid or symbol as shown in the table 8 as set forth in Example 2


      <400> 2601
 Lys Arg Gly Ser Val Arg Lys Leu Lys Ala Pro Asn Pro Xaa Leu Arg
   1               5                  10                  15    
 Asp Trp Arg Met Lys Asp Arg Met Asn Thr Val Ser Val Ala Leu Val
              20                  25                  30        
 Leu Cys Leu Asn Val Gly Val Asp Pro Pro Asp Val Val Lys Thr Thr
          35                  40                  45            
 Pro Cys Ala Arg Leu Glu Cys Trp Ile Asp Pro Leu Ser Met Gly Pro
      50                  55                  60                
 Gln Lys Ala Leu Gly Thr Ile Gly Ala Asn Leu Gln Lys Gln Tyr Glu
  65                  70                  75                  80
 Asn Trp Gln Pro Arg Ala Arg Tyr Lys Gln Ser Leu Asp Pro Thr Val
                  85                  90                  95    
 Asp Glu Val Lys Lys Leu Cys Thr Ser Leu Arg Arg Asn Ala Lys Glu
             100                 105                 110        
 Glu Arg Val Leu Phe His Tyr Asn Gly His Gly Val Pro Arg Pro Thr
         115                 120                 125            
 Val Asn Gly Glu Val Trp Val Phe Asn Lys Asn Tyr Thr Gln Tyr Ile
     130                 135                 140                
 Pro Leu Ser Ile Tyr Asp Leu Gln Thr Trp Met Gly Ser Pro Ser Ile
 145                 150                 155                 160
 Phe Val Tyr Asp Cys Ser Asn Ala Gly Leu Ile Val Lys Ser Phe Lys
                 165                 170                 175    
 Gln Phe Ala Leu Gln Arg Glu Gln Glu Leu Glu Val Ala Ala Ile Asn
             180                 185                 190        
 Pro Asn His Pro Leu Ala Gln Met Pro Leu Pro Pro Ser Met Lys Asn
         195                 200                 205            
 Cys Ile Gln Leu Ala Ala Cys Glu Ala Thr Glu Leu Leu Pro Met Ile
     210                 215                 220                
 Pro Asp Leu Pro Ala Asp Leu Phe Thr Ser Cys Leu Thr Thr Pro Ile
 225                 230                 235                 240
 Lys Ile Ala Leu Arg Trp Phe Cys Met Gln Lys Cys Val Ser Leu Val
                 245                 250                 255    
 Pro Gly Val Thr Leu Asp Leu Ile Glu Lys
             260                 265    



      <210> 2602
      <211> 104
      <212> PRT
      <213> Homo sapiens


      <400> 2602
 Ile Gly Ile Ser Cys Pro Ala Thr Ile Phe Val Pro Met Phe Ser His
   1               5                  10                  15    
 Ser Leu Ile Gly Ile Gly Glu Glu Tyr Gln Leu Pro Tyr Tyr Asn Met
              20                  25                  30        
 Val Pro Ser Asp Pro Ser Tyr Glu Asp Met Arg Glu Val Val Cys Val
          35                  40                  45            
 Lys Arg Leu Arg Pro Ile Val Ser Asn Arg Trp Asn Ser Asp Glu Cys
      50                  55                  60                
 Leu Arg Ala Val Leu Lys Leu Met Ser Glu Cys Trp Ala His Asn Pro
  65                  70                  75                  80
 Ala Ser Arg Leu Thr Ala Leu Arg Ile Lys Lys Thr Leu Ala Lys Met
                  85                  90                  95    
 Val Glu Ser Gln Asp Val Lys Ile
             100                



      <210> 2603
      <211> 104
      <212> PRT
      <213> Homo sapiens


      <400> 2603
 Ile Gly Ile Ser Cys Pro Ala Thr Ile Phe Val Pro Met Phe Ser His
   1               5                  10                  15    
 Ser Leu Ile Gly Ile Gly Glu Glu Tyr Gln Leu Pro Tyr Tyr Asn Met
              20                  25                  30        
 Val Pro Ser Asp Pro Ser Tyr Glu Asp Met Arg Glu Val Val Cys Val
          35                  40                  45            
 Lys Arg Leu Arg Pro Ile Val Ser Asn Arg Trp Asn Ser Asp Glu Cys
      50                  55                  60                
 Leu Arg Ala Val Leu Lys Leu Met Ser Glu Cys Trp Ala His Asn Pro
  65                  70                  75                  80
 Ala Ser Arg Leu Thr Ala Leu Arg Ile Lys Lys Thr Leu Ala Lys Met
                  85                  90                  95    
 Val Glu Ser Gln Asp Val Lys Ile
             100                



      <210> 2604
      <211> 158
      <212> PRT
      <213> Homo sapiens


      <400> 2604
 Ala Ala Gly Val Gln Met Lys Leu Glu Phe Leu Gln Arg Lys Phe Trp
   1               5                  10                  15    
 Ala Ala Thr Arg Gln Cys Ser Thr Val Asp Gly Pro Cys Thr Gln Ser
              20                  25                  30        
 Cys Glu Asp Ser Asp Leu Asp Cys Phe Val Ile Asp Asn Asn Gly Phe
          35                  40                  45            
 Ile Leu Ile Ser Lys Arg Ser Arg Glu Thr Gly Arg Phe Leu Gly Glu
      50                  55                  60                
 Val Asp Gly Ala Val Leu Thr Gln Leu Leu Ser Met Gly Val Phe Ser
  65                  70                  75                  80
 Gln Val Thr Met Tyr Asp Tyr Gln Ala Met Cys Lys Pro Ser Ser His
                  85                  90                  95    
 His His Ser Ala Ala Gln Pro Leu Val Ser Pro Ile Ser Ala Phe Leu
             100                 105                 110        
 Thr Ala Thr Arg Trp Leu Leu Gln Glu Leu Val Leu Phe Leu Leu Glu
         115                 120                 125            
 Trp Ser Val Trp Gly Ser Trp Tyr Asp Arg Gly Ala Glu Ala Lys Ser
     130                 135                 140                
 Cys Leu Pro Ser Leu Pro Gln Thr Gln Glu Ala Gly Pro Ala
 145                 150                 155            



      <210> 2605
      <211> 168
      <212> PRT
      <213> Homo sapiens


      <400> 2605
 Asp Ile Glu His Thr Glu Gly Lys Arg Tyr Phe Thr Trp Asp Lys Asn
   1               5                  10                  15    
 Arg Phe Pro Asn Pro Lys Arg Met Gln Glu Leu Leu Arg Asn Lys Lys
              20                  25                  30        
 Arg Lys Leu Val Val Ile Ser Asp Pro His Ile Lys Ile Asp Pro Asp
          35                  40                  45            
 Tyr Ser Val Tyr Val Lys Ala Lys Asp Gln Gly Phe Phe Val Lys Asn
      50                  55                  60                
 Gln Glu Gly Glu Asp Phe Glu Gly Val Cys Trp Pro Gly Leu Ser Ser
  65                  70                  75                  80
 Tyr Leu Asp Phe Thr Asn Pro Lys Val Arg Glu Trp Tyr Ser Ser Leu
                  85                  90                  95    
 Phe Ala Phe Pro Val Tyr Gln Gly Ser Thr Asp Ile Leu Phe Leu Trp
             100                 105                 110        
 Asn Asp Met Asn Glu Pro Ser Val Phe Arg Gly Pro Glu Gln Thr Met
         115                 120                 125            
 Gln Lys Asn Ala Ile His His Gly Asn Trp Glu His Arg Glu Leu His
     130                 135                 140                
 Asn Ile Tyr Gly Phe Tyr His Val Arg His Pro Lys Arg Ile Lys Leu
 145                 150                 155                 160
 Gly Leu Cys Asp Pro Pro Phe Gly
                 165            



      <210> 2606
      <211> 712
      <212> PRT
      <213> Homo sapiens


      <400> 2606
 Phe Glu Gln Asn Thr Lys Leu Asp Gln Ala Gln Gln Ala Pro Glu Asp
   1               5                  10                  15    
 His Tyr Pro Ile Ser Leu Leu Leu Pro Ser His Met Ala Ile Gly Leu
              20                  25                  30        
 Leu Met Ala Gln Glu Gly His Cys Lys Asp Ser Ser Ala Met Gly Glu
          35                  40                  45            
 Glu Ala His His Pro Leu Thr Pro Ala Thr Pro Pro Phe Pro Pro Leu
      50                  55                  60                
 Ser Pro Asp Trp Gly His Met Gln Pro Asp Phe Phe Val Pro Val Ala
  65                  70                  75                  80
 Val Pro Ala Val Phe Arg Gly Pro Pro Gln Leu Gln Cys His Gly Arg
                  85                  90                  95    
 Arg Leu Phe Leu Asn Ser Pro Cys Ala Gln Lys Ser Ser Ser Gly Leu
             100                 105                 110        
 Val Val Glu Pro Gly Leu Ser Arg Thr Leu Leu Glu Met Val Lys Leu
         115                 120                 125            
 Thr Ser Met Arg Gly Gln Phe Leu Glu Ala Gln Ile Pro Thr Gly Ile
     130                 135                 140                
 Ser Leu Thr Leu Gln Tyr Gln Leu Tyr Gln Lys Gln Thr Asn Lys Asn
 145                 150                 155                 160
 Met Ser Tyr Ser Phe Val Leu Phe Leu Lys Trp Val Ala Leu Gly Gln
                 165                 170                 175    
 Gly Arg Arg Ala Gly Tyr Pro Ser Leu Glu Asp Ala Asp Ser Arg Arg
             180                 185                 190        
 Phe Asn Gly Ser Arg Ser Phe Leu Ile Thr Val Ile Gly Ile Thr Leu
         195                 200                 205            
 Thr Val Glu Ile Val Thr Ser Gly Met Met Lys Gly Thr Arg Val Arg
     210                 215                 220                
 Trp Ser Gly Ala Gly Asn Glu Gly Met Met Gly Leu Glu Glu Gly Arg
 225                 230                 235                 240
 Asn Glu Arg Ser Val Lys Glu Ala Pro Pro Arg Arg Ala Val Glu Ala
                 245                 250                 255    
 Gln Pro Lys Asp Arg Thr Trp Asp Val Gly Lys Gly Gln Gly Thr Glu
             260                 265                 270        
 Gly Glu Gly Arg Gly Leu Glu Val Glu Gly Gln Gln His Gln Gly Ser
         275                 280                 285            
 Glu Pro Gly Thr Ile Pro Phe Ser Val Ser Trp Gly Val Leu Leu Leu
     290                 295                 300                
 Ala Gly Leu Cys Cys Leu Val Pro Ser Ser Leu Val Glu Asp Pro Gln
 305                 310                 315                 320
 Glu Asp Ala Ala Gln Lys Thr Asp Thr Ser His His Asp Gln Gly Asp
                 325                 330                 335    
 Trp Glu Asp Leu Ala Cys Gln Lys Ile Ser Tyr Asn Val Thr Asp Leu
             340                 345                 350        
 Ala Phe Asp Leu Tyr Lys Ser Trp Leu Ile Tyr His Asn Gln His Val
         355                 360                 365            
 Leu Val Thr Pro Thr Ser Val Ala Met Ala Phe Ala Met Leu Ser Leu
     370                 375                 380                
 Gly Thr Lys Ala Asp Thr Arg Thr Glu Ile Leu Glu Gly Leu Asn Val
 385                 390                 395                 400
 Asn Leu Thr Glu Thr Pro Glu Ala Lys Ile His Glu Cys Phe Gln Gln
                 405                 410                 415    
 Val Leu Gln Ala Leu Ser Arg Pro Asp Thr Arg Leu Gln Leu Thr Thr
             420                 425                 430        
 Gly Ser Ser Leu Phe Val Asn Lys Ser Met Lys Leu Val Asp Thr Phe
         435                 440                 445            
 Leu Glu Asp Thr Lys Lys Leu Tyr His Ser Glu Ala Ser Ser Ile Asn
     450                 455                 460                
 Phe Arg Asp Thr Glu Glu Ala Lys Glu Gln Ile Asn Asn Tyr Val Glu
 465                 470                 475                 480
 Lys Arg Thr Gly Arg Lys Val Val Asp Leu Val Lys His Leu Lys Lys
                 485                 490                 495    
 Asp Thr Ser Leu Ala Leu Val Asp Tyr Ile Ser Phe His Gly Lys Trp
             500                 505                 510        
 Lys Asp Lys Phe Lys Ala Glu Arg Ile Met Val Glu Gly Phe His Val
         515                 520                 525            
 Asp Asp Lys Thr Ile Ile Arg Val Pro Met Ile Asn His Leu Gly Arg
     530                 535                 540                
 Phe Asp Ile His Arg Asp Arg Glu Leu Ser Ser Trp Val Leu Ala Gln
 545                 550                 555                 560
 His Tyr Val Gly Asn Ala Thr Ala Phe Phe Ile Leu Pro Asp Pro Lys
                 565                 570                 575    
 Lys Met Trp Gln Leu Glu Glu Lys Leu Thr Tyr Ser His Leu Glu Asn
             580                 585                 590        
 Ile Gln Arg Ala Phe Asp Ile Arg Ser Ile Asn Leu His Phe Pro Lys
         595                 600                 605            
 Leu Ser Ile Ser Gly Thr Tyr Lys Leu Lys Arg Val Pro Arg Asn Leu
     610                 615                 620                
 Gly Ile Thr Lys Ile Phe Ser Asn Glu Ala Asp Leu Ser Gly Val Ser
 625                 630                 635                 640
 Gln Glu Ala Pro Leu Lys Leu Ser Lys Ala Val His Val Ala Val Leu
                 645                 650                 655    
 Thr Ile Asp Glu Lys Gly Thr Glu Ala Thr Gly Ala Pro His Leu Glu
             660                 665                 670        
 Glu Lys Ala Trp Ser Lys Tyr Gln Thr Val Met Phe Asn Arg Pro Phe
         675                 680                 685            
 Leu Val Ile Ile Lys Glu Tyr Ile Thr Asn Phe Pro Leu Phe Ile Gly
     690                 695                 700                
 Lys Val Val Asn Pro Thr Gln Lys
 705                 710        



      <210> 2607
      <211> 281
      <212> PRT
      <213> Homo sapiens


      <400> 2607
 Thr Leu Arg Ala Arg Ala Leu Gln Ala Arg Pro Arg Thr Gly Ser Ser
   1               5                  10                  15    
 Cys Thr Ala Ala Thr Trp Thr Ser Ser Gly Ala Ser Gln His Ser Leu
              20                  25                  30        
 Arg Ala Leu Ser Trp Arg Arg Leu Tyr Leu Ser Arg Ala Lys Leu Lys
          35                  40                  45            
 Ala Ser Ser Arg Thr Ser Ala Leu Leu Ser Gly Phe Ala Met Val Ala
      50                  55                  60                
 Met Val Glu Val Gln Leu Glu Ser Asp His Glu Tyr Pro Pro Gly Leu
  65                  70                  75                  80
 Leu Val Ala Phe Ser Ala Cys Thr Thr Val Leu Val Ala Val His Leu
                  85                  90                  95    
 Phe Ala Leu Met Val Ser Thr Cys Leu Leu Pro His Ile Glu Ala Val
             100                 105                 110        
 Ser Asn Ile His Asn Leu Asn Ser Val His Gln Ser Pro His Gln Arg
         115                 120                 125            
 Leu His Arg Tyr Val Glu Leu Ala Trp Gly Phe Ser Thr Ala Leu Gly
     130                 135                 140                
 Thr Phe Leu Phe Leu Ala Glu Val Val Leu Val Gly Trp Val Lys Phe
 145                 150                 155                 160
 Val Pro Ile Gly Ala Pro Leu Asp Thr Pro Thr Pro Met Val Pro Thr
                 165                 170                 175    
 Ser Arg Val Pro Gly Thr Leu Ala Pro Val Ala Thr Ser Leu Ser Pro
             180                 185                 190        
 Ala Ser Asn Leu Pro Arg Ser Ser Ala Ser Ala Ala Pro Ser Gln Ala
         195                 200                 205            
 Glu Pro Ala Cys Pro Pro Arg Gln Ala Cys Gly Gly Gly Gly Ala His
     210                 215                 220                
 Gly Pro Gly Trp Gln Ala Ala Met Ala Ser Thr Ala Ile Met Val Pro
 225                 230                 235                 240
 Val Gly Leu Val Phe Val Ala Phe Ala Leu His Phe Tyr Arg Ser Leu
                 245                 250                 255    
 Val Ala His Lys Thr Asp Arg Tyr Lys Gln Glu Leu Glu Glu Leu Asn
             260                 265                 270        
 Arg Leu Gln Gly Glu Leu Gln Ala Val
         275                 280    



      <210> 2608
      <211> 111
      <212> PRT
      <213> Homo sapiens


      <400> 2608
 Met Met Thr Val Tyr Pro Leu Leu Gly Tyr Leu Ala Arg Val Gln Leu
   1               5                  10                  15    
 Leu Gly His Ile Phe Gly Asp Ile Tyr Pro Ser Ile Phe His Val Leu
              20                  25                  30        
 Ile Leu Asn Leu Ile Ile Val Gly Ala Gly Val Ile Met Ala Cys Phe
          35                  40                  45            
 Tyr Pro Asn Ile Gly Gly Ile Ile Arg Tyr Ser Gly Ala Ala Cys Gly
      50                  55                  60                
 Leu Ala Phe Val Phe Ile Tyr Pro Ser Leu Ile Tyr Ile Ile Ser Leu
  65                  70                  75                  80
 His Gln Glu Glu Arg Leu Thr Trp Pro Lys Leu Ile Phe His Val Phe
                  85                  90                  95    
 Ile Ile Ile Leu Gly Val Ala Asn Leu Ile Val Gln Phe Phe Met
             100                 105                 110    



      <210> 2609
      <211> 581
      <212> PRT
      <213> Homo sapiens


      <400> 2609
 Gly Thr Ser Thr Val Thr Met Ala Thr Lys Lys His Phe Ser Ile Ile
   1               5                  10                  15    
 Leu Asn Leu Leu Gly Met Leu Leu Lys Lys Asp Asn Gln Asp Thr Arg
              20                  25                  30        
 Lys Leu Leu Met Thr Trp Ala Leu Glu Val Ala Val Val Met Lys Lys
          35                  40                  45            
 Ser Glu Thr Tyr Ala Pro Leu Phe Cys Leu Pro Ser Phe His Lys Phe
      50                  55                  60                
 Cys Lys Gly Leu Leu Ala Asp Thr Leu Val Glu Asp Val Asn Ile Cys
  65                  70                  75                  80
 Leu Gln Ala Cys Ser Ser Leu His Ala Leu Ser Ser Ser Leu Pro Asp
                  85                  90                  95    
 Asp Leu Leu Gln Arg Cys Val Asp Val Cys Arg Val Gln Leu Val His
             100                 105                 110        
 Arg Gly Thr Cys Ile Arg Gln Ala Phe Gly Lys Leu Leu Lys Ser Ile
         115                 120                 125            
 Pro Leu Gly Val Phe Leu Ser Asn Asn Asn His Thr Glu Ile Gln Glu
     130                 135                 140                
 Ile Ser Leu Ala Leu Arg Ser His Met Ser Lys Ala Pro Ser Asn Thr
 145                 150                 155                 160
 Phe His Pro Gln Asp Phe Ser Asp Val Ile Ser Phe Ile Leu Tyr Gly
                 165                 170                 175    
 Asn Ser His Arg Thr Gly Lys Asp Asn Trp Leu Glu Arg Leu Phe Tyr
             180                 185                 190        
 Ser Cys Gln Arg Leu Asp Lys Arg Asp Gln Ser Thr Ile Pro Arg Asn
         195                 200                 205            
 Leu Leu Lys Thr Asp Ala Val Leu Trp Gln Trp Ala Ile Trp Glu Ala
     210                 215                 220                
 Ala Gln Phe Thr Val Leu Ser Lys Leu Arg Thr Pro Leu Gly Arg Ala
 225                 230                 235                 240
 Gln Asp Thr Phe Gln Thr Ile Glu Gly Ile Ile Arg Ser Leu Ala Gly
                 245                 250                 255    
 His Thr Leu Asn Pro Asp Gln Asp Val Ser Gln Trp Thr Thr Ala Asp
             260                 265                 270        
 Asn Asp Glu Gly His Gly Asn Asn Gln Leu Arg Leu Val Leu Leu Leu
         275                 280                 285            
 Gln Tyr Leu Glu Asn Leu Glu Lys Leu Met Tyr Asn Ala Tyr Glu Gly
     290                 295                 300                
 Cys Ala Asn Ala Leu Thr Ser Pro Pro Lys Val Ile Arg Thr Phe Leu
 305                 310                 315                 320
 Tyr Thr Asn Arg Gln Thr Cys Gln Asp Trp Leu Thr Arg Ile Arg Leu
                 325                 330                 335    
 Ser Ile Met Arg Val Gly Leu Leu Ala Gly Gln Pro Ala Val Thr Val
             340                 345                 350        
 Arg His Gly Phe Asp Leu Leu Thr Glu Met Lys Thr Thr Ser Leu Ser
         355                 360                 365            
 Gln Gly Asn Glu Leu Glu Val Ser Ile Met Met Val Val Glu Ala Leu
     370                 375                 380                
 Cys Glu Leu His Cys Pro Glu Ala Ile Gln Gly Ile Ala Val Trp Ser
 385                 390                 395                 400
 Ser Ser Ile Val Gly Lys His Leu Leu Trp Ile Asn Ser Val Ala Gln
                 405                 410                 415    
 Gln Ala Glu Gly Arg Phe Glu Lys Ala Ser Val Glu Tyr Gln Glu His
             420                 425                 430        
 Leu Cys Ala Met Thr Gly Val Asp Cys Cys Ile Ser Ser Phe Asp Lys
         435                 440                 445            
 Ser Val Leu Thr Leu Ala Ser Ala Gly Cys Lys Ser Ala Ser Leu Lys
     450                 455                 460                
 His Cys Leu Asn Gly Glu Ser Arg Lys Ser Val Leu Ser Lys Pro Thr
 465                 470                 475                 480
 Asp Ser Ser Pro Glu Val Ile Asn Tyr Leu Gly Asn Lys Ala Cys Glu
                 485                 490                 495    
 Cys Tyr Ile Ser Thr Ala Asp Trp Ala Ala Val Gln Glu Trp Gln Asn
             500                 505                 510        
 Ala Ile His Asp Leu Lys Lys Ser Thr Ser Ser Thr Ser Leu Asn Leu
         515                 520                 525            
 Lys Ala Asp Phe Asn Tyr Ile Lys Ser Leu Ser Ser Phe Glu Ser Gly
     530                 535                 540                
 Lys Phe Val Glu Cys Thr Glu Gln Leu Glu Leu Leu Pro Gly Glu Asn
 545                 550                 555                 560
 Ile Asn Leu Leu Ala Gly Gly Ser Lys Glu Lys Ile Asp Met Lys Lys
                 565                 570                 575    
 Leu Leu Arg Asn Met
             580    



      <210> 2610
      <211> 273
      <212> PRT
      <213> Homo sapiens

      <220>
      <221> misc_feature
      <222> (1)...(273)
      <223> Xaa = any amino acid or symbol as shown in the table 8 as set forth in Example 2


      <400> 2610
 Asn Pro Asn Pro Ser Ile Gly Asp Ile Lys Asp Ile Lys Lys Ala Ala
   1               5                  10                  15    
 Lys Ser Met Leu Asp Pro Ala His Lys Ser His Phe His Pro Val Thr
              20                  25                  30        
 Pro Ser Leu Val Phe Leu Cys Phe Ile Phe Asp Gly Leu His Gln Ala
          35                  40                  45            
 Leu Leu Ser Val Gly Val Ser Lys Arg Ser Asn Thr Val Val Gly Asn
      50                  55                  60                
 Glu Asn Glu Glu Arg Gly Thr Pro Tyr Ala Ser Arg Phe Lys Asp Met
  65                  70                  75                  80
 Pro Asn Phe Ile Ala Leu Glu Lys Ser Ser Val Leu Arg His Cys Cys
                  85                  90                  95    
 Asp Leu Leu Ile Gly Val Ala Ala Gly Ser Ser Asp Lys Ile Cys Thr
             100                 105                 110        
 Ser Ser Leu Gln Val Gln Arg Arg Phe Lys Ala Met Met Ala Ser Ile
         115                 120                 125            
 Gly Arg Leu Ser His Gly Glu Ser Ala Asp Leu Leu Ile Ser Cys Asn
     130                 135                 140                
 Ala Glu Ser Ala Ile Gly Trp Ile Ser Ser Arg Pro Trp Val Gly Glu
 145                 150                 155                 160
 Leu Met Phe Thr Phe Leu Phe Gly Asp Phe Glu Ser Pro Leu His Lys
                 165                 170                 175    
 Leu Arg Lys Ser Ser Xaa Leu Pro Arg Lys His Arg Xaa Gln Pro Ile
             180                 185                 190        
 Asn Ala Val Arg Met Phe Leu Asp Gln Cys Met Asp Gly Ser Ile Ala
         195                 200                 205            
 Leu Arg Ala Ile Val Ser Glu Ile Pro Val Phe Glu Glu Lys Lys Asn
     210                 215                 220                
 Asn Gly Xaa Lys Gly Ile Gly Glu Ile Phe Xaa Val Trp Gly Cys Thr
 225                 230                 235                 240
 Leu Pro Pro His Tyr Trp Gly Ala Val Thr Thr Asn Val Pro Lys Leu
                 245                 250                 255    
 Ser Asn Ser Gly Lys Leu Leu Gly Gln Asp Glu Gln Pro His Ile Phe
             260                 265                 270        
 Gly
    



      <210> 2611
      <211> 220
      <212> PRT
      <213> Homo sapiens


      <400> 2611
 Met Met Met Val Met Met Val Val Met Val Val Val Val Val Val Val
   1               5                  10                  15    
 Glu Leu Arg Ala Ile Lys Met Gln Met Glu Asp Arg Trp Ser Asn Arg
              20                  25                  30        
 Pro Asp Thr Ala Thr Ala Leu Ala Gly Gly Ala Val Met Pro Glu Leu
          35                  40                  45            
 Ile Leu Tyr Val Ala Ile Thr Leu Ser Val Ala Glu Arg Leu Val Gly
      50                  55                  60                
 Pro Ala Pro His Pro Leu Lys Met Phe Ala Cys Ser Lys Phe Val Ser
  65                  70                  75                  80
 Thr Pro Ser Leu Val Lys Ser Thr Ser Gln Leu Leu Ser Arg Pro Leu
                  85                  90                  95    
 Ser Ala Val Val Leu Lys Arg Pro Glu Ile Leu Thr Asp Glu Ser Leu
             100                 105                 110        
 Ser Lys Leu Gly Ser Leu Met Ser Pro Leu Thr Ser Thr Cys Leu Leu
         115                 120                 125            
 Asn Arg Lys Leu Pro Lys Pro Ala Pro Ile Ser Lys Gly Thr Ser Asn
     130                 135                 140                
 Asn Ser Ser Pro Lys Phe Asn Trp Lys Leu Gly Leu Ala Thr Ser Trp
 145                 150                 155                 160
 Gly Gly Trp Phe Leu Gly Leu Gly Leu Glu Thr Val Phe Gly Glu Pro
                 165                 170                 175    
 Ser Ser Leu Gly Tyr Ala Arg Asn Pro Ser Leu Lys Gln Gln Leu Phe
             180                 185                 190        
 Ser Tyr Ala Ile Leu Gly Phe Ala Leu Ser Glu Ala Met Gly Leu Phe
         195                 200                 205            
 Cys Leu Met Val Ala Phe Leu Ile Leu Phe Ala Met
     210                 215                 220



      <210> 2612
      <211> 1013
      <212> PRT
      <213> Homo sapiens

      <220>
      <221> misc_feature
      <222> (1)...(1013)
      <223> Xaa = any amino acid or symbol as shown in the table 8 as set forth in Example 2


      <400> 2612
 Phe Arg Ala Ala Leu Ala Ile Phe Ala Arg Ala Cys Phe Leu Leu Ser
   1               5                  10                  15    
 Ser Leu Ala Ser Leu Pro Val Phe Leu Pro Val Phe Pro Ala Arg Pro
              20                  25                  30        
 Pro Pro Ser Ser Pro Ala Gly Pro Leu Pro Gly Gly Ile Ile Trp Ser
          35                  40                  45            
 Pro Ala Met Asp Ala Pro Lys Ala Gly Tyr Ala Phe Glu Tyr Leu Ile
      50                  55                  60                
 Glu Thr Leu Asn Asp Ser Ser His Lys Lys Phe Phe Asp Val Ser Lys
  65                  70                  75                  80
 Leu Gly Thr Lys Tyr Asp Val Leu Pro Tyr Ser Ile Arg Val Leu Leu
                  85                  90                  95    
 Glu Ala Ala Val Arg Asn Cys Asp Gly Phe Leu Met Lys Lys Glu Asp
             100                 105                 110        
 Val Met Asn Ile Leu Asp Trp Lys Thr Lys Gln Ser Asn Val Glu Val
         115                 120                 125            
 Pro Phe Phe Pro Ala Arg Val Leu Leu Gln Asp Phe Thr Gly Ile Pro
     130                 135                 140                
 Ala Met Val Asp Phe Ala Ala Met Arg Glu Ala Val Lys Thr Leu Gly
 145                 150                 155                 160
 Gly Asp Pro Glu Lys Val His Pro Ala Cys Pro Thr Asp Leu Thr Val
                 165                 170                 175    
 Asp His Ser Leu Gln Ile Asp Phe Ser Lys Cys Ala Ile Gln Asn Ala
             180                 185                 190        
 Pro Asn Pro Gly Gly Gly Asp Leu Gln Lys Ala Gly Lys Leu Ser Pro
         195                 200                 205            
 Leu Lys Val Gln Pro Lys Lys Leu Pro Cys Arg Gly Gln Thr Thr Cys
     210                 215                 220                
 Arg Gly Ser Cys Asp Ser Gly Glu Leu Gly Arg Asn Ser Gly Thr Phe
 225                 230                 235                 240
 Ser Ser Gln Ile Glu Asn Thr Pro Ile Leu Cys Pro Phe His Leu Gln
                 245                 250                 255    
 Pro Val Pro Glu Pro Glu Thr Val Leu Lys Asn Gln Glu Val Glu Phe
             260                 265                 270        
 Gly Arg Asn Arg Glu Arg Leu Gln Phe Phe Lys Trp Ser Ser Arg Val
         275                 280                 285            
 Phe Lys Asn Val Ala Gly Ile Pro Pro Gly Thr Gly Met Ala His Gln
     290                 295                 300                
 Ile Asn Leu Glu Tyr Leu Ser Arg Val Val Phe Glu Glu Lys Asp Leu
 305                 310                 315                 320
 Leu Phe Pro Asp Ser Val Val Gly Thr Asp Ser His Ile Thr Met Val
                 325                 330                 335    
 Asn Gly Leu Gly Ile Leu Gly Trp Gly Val Gly Gly Ile Glu Thr Glu
             340                 345                 350        
 Ala Val Met Leu Gly Leu Pro Val Ser Leu Thr Leu Pro Glu Val Val
         355                 360                 365            
 Gly Cys Glu Leu Thr Gly Ser Ser Asn Pro Phe Val Thr Ser Ile Asp
     370                 375                 380                
 Val Val Leu Gly Ile Thr Lys His Leu Arg Gln Val Gly Val Ala Gly
 385                 390                 395                 400
 Lys Phe Val Glu Phe Phe Gly Ser Gly Val Ser Gln Leu Ser Ile Val
                 405                 410                 415    
 Asp Arg Thr Thr Ile Ala Asn Met Cys Pro Glu Tyr Gly Ala Ile Leu
             420                 425                 430        
 Ser Phe Phe Pro Val Asp Asn Val Thr Leu Lys His Leu Glu His Thr
         435                 440                 445            
 Gly Phe Ser Lys Ala Lys Leu Glu Ser Met Glu Thr Tyr Leu Lys Ala
     450                 455                 460                
 Val Lys Leu Phe Arg Asn Asp Gln Asn Ser Ser Gly Glu Pro Glu Tyr
 465                 470                 475                 480
 Ser Gln Val Ile Gln Ile Asn Leu Asn Ser Ile Val Pro Ser Val Ser
                 485                 490                 495    
 Gly Pro Lys Arg Pro Gln Asp Arg Val Ala Val Thr Asp Met Lys Ser
             500                 505                 510        
 Asp Phe Gln Ala Cys Leu Asn Glu Lys Val Gly Phe Lys Gly Phe Gln
         515                 520                 525            
 Ile Ala Ala Glu Lys Gln Lys Asp Ile Val Ser Ile His Tyr Glu Gly
     530                 535                 540                
 Ser Glu Tyr Lys Leu Ser His Gly Ser Val Val Ile Ala Ala Val Ile
 545                 550                 555                 560
 Ser Cys Thr Asn Asn Cys Asn Pro Ser Val Met Leu Ala Ala Gly Leu
                 565                 570                 575    
 Leu Ala Lys Lys Ala Val Glu Ala Gly Leu Arg Val Lys Pro Tyr Ile
             580                 585                 590        
 Arg Thr Ser Leu Ser Pro Gly Ser Gly Met Val Thr His Tyr Leu Ser
         595                 600                 605            
 Ser Ser Gly Val Leu Pro Tyr Leu Ser Lys Leu Gly Phe Glu Ile Val
     610                 615                 620                
 Gly Tyr Gly Cys Ser Thr Xaa Val Gly Asn Thr Ala Pro Leu Ser Asp
 625                 630                 635                 640
 Ala Val Leu Asn Ala Val Lys Gln Gly Asp Leu Val Thr Cys Gly Ile
                 645                 650                 655    
 Leu Ser Gly Asn Lys Asn Phe Glu Gly Arg Leu Cys Asp Cys Val Arg
             660                 665                 670        
 Ala Asn Tyr Leu Ala Ser Pro Pro Leu Val Val Ala Tyr Ala Ile Ala
         675                 680                 685            
 Gly Thr Val Asn Ile Asp Cys Gln Thr Glu Pro Leu Gly Thr Asp Pro
     690                 695                 700                
 Thr Gly Lys Asn Ile Tyr Leu His Asp Ile Trp Pro Ser Arg Glu Glu
 705                 710                 715                 720
 Val His Arg Val Glu Glu Glu His Val Ile Leu Ser Met Phe Lys Ala
                 725                 730                 735    
 Leu Lys Asp Lys Ile Glu Met Gly Asn Lys Arg Trp Asn Ser Leu Glu
             740                 745                 750        
 Ala Pro Asp Ser Val Leu Phe Pro Trp Asp Leu Lys Ser Thr Tyr Ile
         755                 760                 765            
 Arg Cys Pro Ser Phe Phe Asp Lys Leu Thr Lys Glu Pro Ile Ala Leu
     770                 775                 780                
 Gln Ala Ile Glu Asn Ala His Val Leu Leu Tyr Leu Gly Asp Ser Val
 785                 790                 795                 800
 Thr Thr Asp His Ile Ser Pro Ala Lys Ser Ile Ala Arg Asn Ser Ala
                 805                 810                 815    
 Ala Ala Lys Tyr Leu Thr Asn Arg Gly Leu Thr Pro Arg Glu Phe Asn
             820                 825                 830        
 Ser Tyr Gly Ala Arg Arg Gly Asn Asp Ala Val Met Thr Arg Gly Thr
         835                 840                 845            
 Phe Ala Asn Ile Lys Leu Phe Asn Lys Phe Ile Gly Lys Pro Ala Pro
     850                 855                 860                
 Lys Thr Ile His Phe Pro Ser Gly Gln Thr Leu Asp Val Phe Glu Ala
 865                 870                 875                 880
 Ala Glu Leu Tyr Gln Lys Glu Gly Ile Pro Leu Ile Ile Leu Ala Gly
                 885                 890                 895    
 Lys Lys Tyr Gly Ser Gly Asn Ser Arg Asp Trp Ala Ala Lys Gly Pro
             900                 905                 910        
 Tyr Leu Leu Gly Val Lys Ala Val Leu Ala Glu Ser Tyr Glu Lys Ile
         915                 920                 925            
 His Lys Asp His Leu Ile Gly Ile Gly Ile Ala Pro Leu Gln Phe Leu
     930                 935                 940                
 Pro Gly Glu Asn Ala Asp Ser Leu Gly Leu Ser Gly Arg Glu Thr Phe
 945                 950                 955                 960
 Ser Leu Thr Phe Pro Glu Glu Leu Ser Pro Gly Ile Thr Leu Asn Ile
                 965                 970                 975    
 Gln Thr Ser Thr Gly Lys Val Phe Ser Val Ile Ala Ser Phe Glu Asp
             980                 985                 990        
 Asp Val Glu Ile Thr Leu Tyr Lys His Gly Gly Leu Leu Asn Phe Val
         995                1000                1005            
 Ala Arg Lys Phe Ser
    1010            



      <210> 2613
      <211> 172
      <212> PRT
      <213> Homo sapiens

      <220>
      <221> misc_feature
      <222> (1)...(172)
      <223> Xaa = any amino acid or symbol as shown in the table 8 as set forth in Example 2


      <400> 2613
 Xaa Thr Ser Lys Ser Trp Leu His Gly Ser Ile Phe Gly Asp Ile Asn
   1               5                  10                  15    
 Ser Ser Pro Ser Glu Asp Asn Trp Leu Lys Gly Thr Arg Arg Leu Asp
              20                  25                  30        
 Thr Asp His Cys Asn Gly Asn Ala Asp Asp Leu Asp Cys Ser Ser Leu
          35                  40                  45            
 Thr Asp Asp Trp Glu Ser Gly Lys Met Asn Ala Glu Ser Val Ile Thr
      50                  55                  60                
 Ser Ser Ser Ser His Ile Ile Ser Gln Pro Pro Gly Gly Asn Ser His
  65                  70                  75                  80
 Ser Leu Ser Leu Gln Ser Gln Leu Thr Ala Ser Glu Arg Phe Gln Glu
                  85                  90                  95    
 Asn Ser Ser Asp His Ser Glu Thr Arg Leu Leu Gln Glu Val Phe Phe
             100                 105                 110        
 Gln Ala Ile Leu Leu Ala Val Cys Leu Ile Ile Ser Ala Cys Ala Arg
         115                 120                 125            
 Trp Phe Met Gly Glu Ile Leu Ala Ser Val Phe Thr Cys Ser Leu Met
     130                 135                 140                
 Ile Thr Val Ala Tyr Val Lys Ser Leu Phe Leu Ser Leu Ala Ser Tyr
 145                 150                 155                 160
 Phe Lys Thr Thr Ala Cys Ala Arg Phe Val Lys Ile
                 165                 170        



      <210> 2614
      <211> 172
      <212> PRT
      <213> Homo sapiens

      <220>
      <221> misc_feature
      <222> (1)...(172)
      <223> Xaa = any amino acid or symbol as shown in the table 8 as set forth in Example 2


      <400> 2614
 Xaa Thr Ser Lys Ser Trp Leu His Gly Ser Ile Phe Gly Asp Ile Asn
   1               5                  10                  15    
 Ser Ser Pro Ser Glu Asp Asn Trp Leu Lys Gly Thr Arg Arg Leu Asp
              20                  25                  30        
 Thr Asp His Cys Asn Gly Asn Ala Asp Asp Leu Asp Cys Ser Ser Leu
          35                  40                  45            
 Thr Asp Asp Trp Glu Ser Gly Lys Met Asn Ala Glu Ser Val Ile Thr
      50                  55                  60                
 Ser Ser Ser Ser His Ile Ile Ser Gln Pro Pro Gly Gly Asn Ser His
  65                  70                  75                  80
 Ser Leu Ser Leu Gln Ser Gln Leu Thr Ala Ser Glu Arg Phe Gln Glu
                  85                  90                  95    
 Asn Ser Ser Asp His Ser Glu Thr Arg Leu Leu Gln Glu Val Phe Phe
             100                 105                 110        
 Gln Ala Ile Leu Leu Ala Val Cys Leu Ile Ile Ser Ala Cys Ala Arg
         115                 120                 125            
 Trp Phe Met Gly Glu Ile Leu Ala Ser Val Phe Thr Cys Ser Leu Met
     130                 135                 140                
 Ile Thr Val Ala Tyr Val Lys Ser Leu Phe Leu Ser Leu Ala Ser Tyr
 145                 150                 155                 160
 Phe Lys Thr Thr Ala Cys Ala Arg Phe Val Lys Ile
                 165                 170        



      <210> 2615
      <211> 172
      <212> PRT
      <213> Homo sapiens

      <220>
      <221> misc_feature
      <222> (1)...(172)
      <223> Xaa = any amino acid or symbol as shown in the table 8 as set forth in Example 2


      <400> 2615
 Xaa Thr Ser Lys Ser Trp Leu His Gly Ser Ile Phe Gly Asp Ile Asn
   1               5                  10                  15    
 Ser Ser Pro Ser Glu Asp Asn Trp Leu Lys Gly Thr Arg Arg Leu Asp
              20                  25                  30        
 Thr Asp His Cys Asn Gly Asn Ala Asp Asp Leu Asp Cys Ser Ser Leu
          35                  40                  45            
 Thr Asp Asp Trp Glu Ser Gly Lys Met Asn Ala Glu Ser Val Ile Thr
      50                  55                  60                
 Ser Ser Ser Ser His Ile Ile Ser Gln Pro Pro Gly Gly Asn Ser His
  65                  70                  75                  80
 Ser Leu Ser Leu Gln Ser Gln Leu Thr Ala Ser Glu Arg Phe Gln Glu
                  85                  90                  95    
 Asn Ser Ser Asp His Ser Glu Thr Arg Leu Leu Gln Glu Val Phe Phe
             100                 105                 110        
 Gln Ala Ile Leu Leu Ala Val Cys Leu Ile Ile Ser Ala Cys Ala Arg
         115                 120                 125            
 Trp Phe Met Gly Glu Ile Leu Ala Ser Val Phe Thr Cys Ser Leu Met
     130                 135                 140                
 Ile Thr Val Ala Tyr Val Lys Ser Leu Phe Leu Ser Leu Ala Ser Tyr
 145                 150                 155                 160
 Phe Lys Thr Thr Ala Cys Ala Arg Phe Val Lys Ile
                 165                 170        



      <210> 2616
      <211> 159
      <212> PRT
      <213> Homo sapiens

      <220>
      <221> misc_feature
      <222> (1)...(159)
      <223> Xaa = any amino acid or symbol as shown in the table 8 as set forth in Example 2


      <400> 2616
 Phe Ile Ile Ala His Pro Asp Thr Val Leu Gly Glu Leu Ser Tyr Phe
   1               5                  10                  15    
 Val Thr Glu Lys Met Ile Ser Ile His Leu Glu Cys Ser Cys Asn Val
              20                  25                  30        
 Trp Arg Val Leu Tyr Tyr Gly Phe Asn Leu Tyr Ile Ile Tyr Ile Arg
          35                  40                  45            
 Tyr Ile Ile Cys Asn Tyr Ile Ser Xaa Tyr Ile Leu Tyr Ile Lys Xaa
      50                  55                  60                
 Tyr Thr Xaa Val Phe Phe Xaa Thr Met Gly Val Tyr Tyr Lys Ile Asn
  65                  70                  75                  80
 Asn Asn Met Gln Thr Val Val Pro Val Tyr Leu Asn Tyr Ile Gln Val
                  85                  90                  95    
 Cys Cys Tyr Xaa Gln Ile Tyr Leu Thr Phe Ile Tyr Tyr Gly Ser His
             100                 105                 110        
 Phe Leu Ile Glu Leu Arg Asn Tyr Xaa Thr Arg Met His Met Leu Leu
         115                 120                 125            
 Tyr Ile Asp Leu Leu Pro Val Phe Thr Leu Pro Leu Pro Phe Met Leu
     130                 135                 140                
 Ser Met Met Leu Asn Met Gly Gly Ile Phe Asn Gly Pro Asn Phe
 145                 150                 155                



      <210> 2617
      <211> 320
      <212> PRT
      <213> Homo sapiens


      <400> 2617
 Ser Arg Ser Cys Val Cys Ser Gln Glu Ser Phe Gly Gly Cys Cys Val
   1               5                  10                  15    
 Ser Gly Leu Ile Ala Met Gly Thr Lys Ala Gln Val Glu Arg Lys Leu
              20                  25                  30        
 Leu Cys Leu Phe Ile Leu Ala Ile Leu Leu Cys Ser Leu Ala Leu Gly
          35                  40                  45            
 Ser Val Thr Val His Ser Ser Glu Pro Glu Val Arg Ile Pro Glu Asn
      50                  55                  60                
 Asn Pro Val Lys Leu Ser Cys Ala Tyr Ser Gly Phe Ser Ser Pro Arg
  65                  70                  75                  80
 Val Glu Trp Lys Phe Asp Gln Gly Asp Thr Thr Arg Leu Val Cys Tyr
                  85                  90                  95    
 Asn Asn Lys Ile Thr Ala Ser Tyr Glu Asp Arg Val Thr Phe Leu Pro
             100                 105                 110        
 Thr Gly Ile Thr Phe Lys Ser Val Thr Arg Glu Asp Thr Gly Thr Tyr
         115                 120                 125            
 Thr Cys Met Val Ser Glu Glu Gly Gly Asn Ser Tyr Gly Glu Val Lys
     130                 135                 140                
 Val Lys Leu Ile Val Leu Val Pro Pro Ser Lys Pro Thr Val Asn Ile
 145                 150                 155                 160
 Pro Ser Ser Ala Thr Ile Gly Asn Arg Ala Val Leu Thr Cys Ser Glu
                 165                 170                 175    
 Gln Asp Gly Ser Pro Pro Ser Glu Tyr Thr Trp Phe Lys Asp Gly Ile
             180                 185                 190        
 Val Met Pro Thr Asn Pro Lys Ser Thr Arg Ala Phe Ser Asn Ser Ser
         195                 200                 205            
 Tyr Val Leu Asn Pro Thr Thr Gly Glu Leu Val Phe Asp Pro Leu Ser
     210                 215                 220                
 Ala Ser Asp Thr Gly Glu Tyr Ser Cys Glu Ala Arg Asn Gly Tyr Gly
 225                 230                 235                 240
 Thr Pro Met Thr Ser Asn Ala Val Arg Met Glu Ala Val Glu Arg Asn
                 245                 250                 255    
 Val Gly Val Ile Val Ala Ala Val Leu Val Thr Leu Ile Leu Leu Gly
             260                 265                 270        
 Ile Leu Val Phe Gly Ile Trp Phe Ala Tyr Ser Arg Gly His Phe Asp
         275                 280                 285            
 Arg Thr Lys Lys Gly Thr Ser Ser Lys Lys Val Ile Tyr Ser Gln Pro
     290                 295                 300                
 Ser Ala Arg Ser Glu Gly Glu Phe Lys Gln Thr Ser Ser Phe Leu Val
 305                 310                 315                 320





      <210> 2618
      <211> 132
      <212> PRT
      <213> Homo sapiens

      <220>
      <221> misc_feature
      <222> (1)...(132)
      <223> Xaa = any amino acid or symbol as shown in the table 8 as set forth in Example 2


      <400> 2618
 His Pro Ile Val Gly Leu Arg Arg Met Gly Asp Phe Lys Ala Cys Gln
   1               5                  10                  15    
 Phe Gln Glu Gly Glu Gly Arg Ser Val Gly Gly Val Ser Arg Ser Pro
              20                  25                  30        
 Xaa Trp Pro Ser Leu Arg Ala Ser Pro Leu Ser Pro Thr Ser Ser Asp
          35                  40                  45            
 Ser Ile Pro Ser Gly His Pro Ala Pro Pro Thr Pro Pro Gln Pro Pro
      50                  55                  60                
 Thr Gln Pro Leu Ser Glu Ala Asn Ser Gln Ser Glu Gly Ser Leu Ser
  65                  70                  75                  80
 Leu Glu Arg Arg Phe Pro Val Thr Xaa Pro Trp Gly Thr Ser Leu Pro
                  85                  90                  95    
 Phe Leu Ser Pro Pro Thr Pro Ser Ala Val Leu Leu Ala Arg Thr Leu
             100                 105                 110        
 Ala Tyr Thr Lys Asp Gly Gly Cys Gly Cys Gly Ala Glu Leu Val Leu
         115                 120                 125            
 Thr Pro Ile Lys
     130        



      <210> 2619
      <211> 182
      <212> PRT
      <213> Homo sapiens


      <400> 2619
 Arg Arg Arg Arg Leu Pro Ser Val Ala Ile Met Ile Ile Tyr Arg Asp
   1               5                  10                  15    
 Leu Ile Ser His Asp Glu Met Phe Ser Asp Ile Tyr Lys Ile Arg Glu
              20                  25                  30        
 Ile Ala Asp Gly Leu Cys Leu Glu Val Glu Gly Lys Met Val Ser Arg
          35                  40                  45            
 Thr Glu Gly Asn Ile Asp Asp Ser Leu Ile Gly Gly Asn Ala Ser Ala
      50                  55                  60                
 Glu Gly Pro Glu Gly Glu Gly Thr Glu Ser Thr Val Ile Thr Gly Val
  65                  70                  75                  80
 Asp Ile Val Met Asn His His Leu Gln Glu Thr Ser Phe Thr Lys Glu
                  85                  90                  95    
 Ala Tyr Lys Lys Tyr Ile Lys Asp Tyr Met Lys Ser Ile Lys Gly Lys
             100                 105                 110        
 Leu Glu Glu Gln Arg Pro Glu Arg Val Lys Pro Phe Met Thr Gly Ala
         115                 120                 125            
 Ala Glu Gln Ile Lys His Ile Leu Ala Asn Phe Lys Asn Tyr Gln Phe
     130                 135                 140                
 Phe Ile Gly Glu Asn Met Asn Pro Asp Gly Met Val Ala Leu Leu Asp
 145                 150                 155                 160
 Tyr Arg Glu Asp Gly Val Thr Pro Tyr Met Ile Phe Phe Lys Asp Gly
                 165                 170                 175    
 Leu Glu Met Glu Lys Cys
             180        



      <210> 2620
      <211> 113
      <212> PRT
      <213> Homo sapiens

      <220>
      <221> misc_feature
      <222> (1)...(113)
      <223> Xaa = any amino acid or symbol as shown in the table 8 as set forth in Example 2


      <400> 2620
 Met Arg His Pro His Arg Leu Gln Pro Gly Cys Arg Gly Met Val Pro
   1               5                  10                  15    
 Val Pro Ala Asp Pro Val Pro Val Gln Ser Ala Glu Asp Leu Ser Leu
              20                  25                  30        
 Phe Leu Ser Thr Arg Cys Val Val Val Leu Leu Ser Ala Glu Leu Val
          35                  40                  45            
 Gln His Phe His Lys Pro Ala Leu Leu Pro Leu Leu Gln Arg Ala Phe
      50                  55                  60                
 His Pro Pro His Arg Val Val Arg Leu Leu Cys Gly Val Arg Asp Ser
  65                  70                  75                  80
 Glu Glu Phe Leu Asp Phe Phe Pro Asp Trp Ala His Trp Gln Glu Leu
                  85                  90                  95    
 Thr Cys Asp Asp Thr Tyr Val Ala Ala Val Lys Lys Ala Ile Ser Glu
             100                 105                 110        
 Xaa
    



      <210> 2621
      <211> 176
      <212> PRT
      <213> Homo sapiens


      <400> 2621
 Thr Thr Thr Met Ser Ser Lys Lys Ala Lys Thr Lys Thr Thr Lys Lys
   1               5                  10                  15    
 Arg Pro Gln Arg Ala Thr Ser Asn Val Phe Ala Met Phe Asp Gln Ser
              20                  25                  30        
 Gln Ile Gln Glu Phe Lys Glu Ala Phe Asn Met Ile Asp Gln Asn Arg
          35                  40                  45            
 Asp Gly Phe Ile Asp Lys Glu Asp Leu His Asp Met Leu Ala Ser Leu
      50                  55                  60                
 Gly Lys Asn Pro Thr Asp Ala Tyr Leu Asp Ala Met Met Asn Glu Ala
  65                  70                  75                  80
 Pro Gly Pro Ile Asn Phe Thr Met Phe Leu Thr Met Phe Gly Glu Lys
                  85                  90                  95    
 Leu Asn Gly Thr Asp Pro Glu Asp Val Ile Arg Asn Ala Phe Ala Ser
             100                 105                 110        
 Cys Phe Asp Glu Glu Ala Thr Gly Thr Ile Gln Glu Asp Tyr Leu Arg
         115                 120                 125            
 Glu Leu Leu Thr Thr Met Gly Asp Arg Phe Thr Asp Glu Glu Val Asp
     130                 135                 140                
 Glu Leu Tyr Arg Glu Ala Pro Ile Asp Lys Lys Gly Asn Phe Asn Tyr
 145                 150                 155                 160
 Ile Glu Phe Thr Arg Ile Leu Lys His Gly Ala Lys Asp Lys Asp Asp
                 165                 170                 175    





      <210> 2622
      <211> 113
      <212> PRT
      <213> Homo sapiens


      <400> 2622
 Pro Glu Glu Thr Pro Leu Pro Thr Leu Pro Glu Arg Gly Ser Leu Arg
   1               5                  10                  15    
 Thr Gly Trp Arg Arg Trp Gly Pro Ser Arg Ala Pro Gly Ala Leu Pro
              20                  25                  30        
 Gly Met Ser Arg Pro Thr His Pro Lys Ala Gly Ala Ala Ala Pro Cys
          35                  40                  45            
 Cys Pro Ser Pro Gly Leu Gly Asn Asp Asp Pro Pro Lys Ser Pro Ser
      50                  55                  60                
 Ala Pro Gln Thr Gln Gly Leu Arg Pro Pro Ala Pro Gly Ile Arg Glu
  65                  70                  75                  80
 Ser Ile Pro Ala Gln His Pro Gln His Pro Arg Val Trp Pro Pro Cys
                  85                  90                  95    
 Thr Ser Leu Ser His Pro Arg Arg Ser Val Pro Leu Ala Pro Gln Cys
             100                 105                 110        
 Pro
    



      <210> 2623
      <211> 78
      <212> PRT
      <213> Homo sapiens


      <400> 2623
 Met Met Tyr Arg Thr His Cys Gln Arg Ile Leu Asp Thr Val Ile Arg
   1               5                  10                  15    
 Ala Asn Phe Asp Glu Val Gln Ser Phe Leu Leu His Phe Trp Gln Gly
              20                  25                  30        
 Met Pro Pro His Met Leu Pro Val Leu Gly Ser Ser Thr Val Val Asn
          35                  40                  45            
 Ile Val Gly Val Cys Asp Ser Ile Leu Tyr Lys Ala Ile Ser Gly Val
      50                  55                  60                
 Leu Met Pro Thr Val Leu Gln Ala Leu Pro Asp Ser Leu Thr
  65                  70                  75            



      <210> 2624
      <211> 83
      <212> PRT
      <213> Homo sapiens

      <220>
      <221> misc_feature
      <222> (1)...(83)
      <223> Xaa = any amino acid or symbol as shown in the table 8 as set forth in Example 2


      <400> 2624
 Leu Gln Ser Ser Arg Ala Ser Arg Trp Thr Arg Pro Ser Ser Pro Pro
   1               5                  10                  15    
 Thr Arg Ala Ser Cys Trp Lys Pro Ser Trp Xaa Gln Leu Pro Pro Asn
              20                  25                  30        
 Leu Val Pro Pro Ser Pro Xaa Pro Pro Ala Pro Gly Gln Pro Tyr Ala
          35                  40                  45            
 Ser Pro Gln Leu Thr Leu Gln Xaa Pro Pro Ser Pro Ser Pro Leu Asp
      50                  55                  60                
 Thr Ser Pro Pro Ala Ala Ala Pro Ser Ser Ser Pro Thr Leu Pro Ser
  65                  70                  75                  80
 Cys Cys Leu
            



      <210> 2625
      <211> 127
      <212> PRT
      <213> Homo sapiens


      <400> 2625
 Ser Arg Tyr Ser Arg Val Asp Asp Phe Val Ala Glu Pro Ser Ser Ala
   1               5                  10                  15    
 Ala Glu Arg Leu Cys Arg His Gly Tyr Thr Met Glu Arg Pro Asp Lys
              20                  25                  30        
 Ala Ala Leu Asn Ala Leu Gln Pro Pro Glu Phe Arg Asn Glu Ser Ser
          35                  40                  45            
 Leu Ala Ser Thr Leu Lys Thr Leu Leu Phe Phe Thr Ala Leu Met Ile
      50                  55                  60                
 Thr Val Pro Ile Gly Leu Tyr Phe Thr Thr Lys Ser Tyr Ile Phe Glu
  65                  70                  75                  80
 Gly Ala Leu Gly Met Ser Asn Arg Asp Ser Tyr Phe Tyr Ala Ala Ile
                  85                  90                  95    
 Val Ala Val Val Ala Val His Val Val Leu Ala Leu Phe Val Tyr Val
             100                 105                 110        
 Ala Trp Asn Glu Gly Ser Arg Gln Trp Arg Glu Gly Lys Gln Asp
         115                 120                 125        



      <210> 2626
      <211> 88
      <212> PRT
      <213> Homo sapiens


      <400> 2626
 Lys Ala Asp Val Lys Asn Leu Ser Gly Lys Asn Arg Pro Val Asn Ser
   1               5                  10                  15    
 Lys Ile His Asp Ile Phe Lys Gly Trp Ala Leu Gln Pro Leu Asp Pro
              20                  25                  30        
 Asp Gly Arg Val Lys Ile Trp Val Tyr Gly Val Ser Gly Gly Ala Phe
          35                  40                  45            
 Leu Ile Met Ile Phe Leu Ile Phe Thr Ser Tyr Leu Val Cys Lys Lys
      50                  55                  60                
 Pro Lys Pro His Gln Ser Thr Pro Pro Gln Gln Lys Pro Leu Thr Leu
  65                  70                  75                  80
 Ser Tyr Asp Gly Asp Leu Asp Met
                  85            



      <210> 2627
      <211> 75
      <212> PRT
      <213> Homo sapiens


      <400> 2627
 Cys Ser Thr Phe Phe Pro Pro Pro Ser Cys Pro Lys Lys Glu Thr Leu
   1               5                  10                  15    
 Leu Pro Pro Lys Ala Gln Ser Pro Lys Pro Lys Lys Ala Pro Ala Lys
              20                  25                  30        
 Lys Gly Glu Lys Val Pro Lys Gly Lys Lys Gly Lys Ala Asp Ala Gly
          35                  40                  45            
 Lys Glu Gly Asn Asn Pro Ala Glu Asn Gly Asp Ala Lys Thr Ala Gln
      50                  55                  60                
 Ala Gln Lys Ala Glu Gly Ala Gly Asp Ala Lys
  65                  70                  75



      <210> 2628
      <211> 156
      <212> PRT
      <213> Homo sapiens


      <400> 2628
 Glu Asn Gly Thr Thr Gly Glu Arg Glu Gly Ser Leu Arg Thr Ile Pro
   1               5                  10                  15    
 Val Thr Arg Ser Pro Leu Val Thr Met Asn His Ile Val Gln Thr Phe
              20                  25                  30        
 Ser Pro Val Asn Ser Gly Gln Pro Pro Asn Tyr Glu Met Leu Lys Glu
          35                  40                  45            
 Glu Gln Glu Val Ala Met Leu Gly Ala Pro His Asn Pro Ala Pro Pro
      50                  55                  60                
 Thr Ser Thr Val Ile His Ile Arg Ser Glu Thr Ser Val Pro Asp His
  65                  70                  75                  80
 Val Val Trp Ser Leu Phe Asn Thr Leu Phe Met Asn Thr Cys Cys Leu
                  85                  90                  95    
 Gly Phe Ile Ala Phe Ala Tyr Ser Val Lys Ser Arg Asp Arg Lys Met
             100                 105                 110        
 Val Gly Asp Val Thr Gly Ala Gln Ala Tyr Ala Ser Thr Ala Lys Cys
         115                 120                 125            
 Leu Asn Ile Trp Ala Leu Ile Leu Gly Ile Phe Met Thr Ile Leu Leu
     130                 135                 140                
 Val Ile Ile Pro Val Leu Val Val Gln Ala Gln Arg
 145                 150                 155    



      <210> 2629
      <211> 272
      <212> PRT
      <213> Homo sapiens


      <400> 2629
 Ile Ile Leu Leu Ile Leu Thr Glu Asp Asp Gly Phe Asn Arg Ser Ile
   1               5                  10                  15    
 His Glu Val Ile Leu Lys Asn Ile Thr Trp Tyr Ser Glu Arg Val Leu
              20                  25                  30        
 Thr Glu Ile Ser Leu Gly Ser Leu Leu Ile Leu Val Val Ile Arg Thr
          35                  40                  45            
 Ile Gln Tyr Asn Met Thr Arg Thr Arg Asp Lys Tyr Leu Asp Thr Asn
      50                  55                  60                
 Cys Leu Ala Ala Leu Ala Asn Met Ser Ala Gln Phe Arg Ser Leu His
  65                  70                  75                  80
 Gln Tyr Ala Ala Gln Arg Ile Ile Ser Leu Phe Ser Leu Leu Ser Lys
                  85                  90                  95    
 Lys His Asn Lys Val Leu Glu Gln Ala Thr Gln Ser Leu Arg Gly Ser
             100                 105                 110        
 Leu Ser Ser Asn Asp Val Pro Leu Pro Asp Tyr Ala Gln Asp Leu Asn
         115                 120                 125            
 Val Ile Glu Glu Val Ile Arg Met Met Leu Glu Ile Ile Asn Ser Cys
     130                 135                 140                
 Leu Thr Asn Ser Leu His His Asn Pro Asn Leu Val Tyr Ala Leu Leu
 145                 150                 155                 160
 Tyr Lys Arg Asp Leu Phe Glu Gln Phe Arg Thr His Pro Ser Phe Gln
                 165                 170                 175    
 Asp Ile Met Gln Asn Ile Asp Leu Val Ile Ser Phe Phe Ser Ser Arg
             180                 185                 190        
 Leu Leu Gln Ala Gly Ala Glu Leu Ser Val Glu Arg Val Leu Glu Ile
         195                 200                 205            
 Ile Lys Gln Gly Val Val Ala Leu Pro Lys Asp Arg Leu Lys Lys Phe
     210                 215                 220                
 Pro Glu Leu Lys Phe Lys Tyr Val Glu Glu Glu Gln Pro Glu Glu Phe
 225                 230                 235                 240
 Phe Ile Pro Tyr Val Trp Ser Leu Val Tyr Asn Ser Ala Ser Arg Pro
                 245                 250                 255    
 Cys Thr Gly Ile His Arg Thr Ser Ser Cys Ser Pro Trp Ile Pro Asp
             260                 265                 270        





      <210> 2630
      <211> 100
      <212> PRT
      <213> Homo sapiens


      <400> 2630
 Asn Leu Pro Gly Trp Thr Val Leu Phe Leu Ser Val Leu Gly Leu Leu
   1               5                  10                  15    
 Ala Ser Arg Ala Val Ser Ala Leu Ser Ser Leu Phe Ala Ala Glu Val
              20                  25                  30        
 Phe Pro Thr Val Ile Arg Gly Ala Gly Leu Gly Leu Val Leu Gly Ala
          35                  40                  45            
 Gly Phe Leu Gly Gln Ala Ala Gly Pro Leu Asp Thr Leu His Gly Arg
      50                  55                  60                
 Gln Gly Phe Phe Leu Gln Gln Val Val Phe Ala Ser Leu Ala Val Leu
  65                  70                  75                  80
 Ala Leu Leu Cys Val Leu Leu Leu Pro Glu Ser Arg Ser Arg Gly Leu
                  85                  90                  95    
 Pro Gln Ser Leu
             100



      <210> 2631
      <211> 223
      <212> PRT
      <213> Homo sapiens


      <400> 2631
 Thr Cys Thr Tyr Lys Tyr Leu Met Gly Trp Ile Arg Gly Arg Arg Ser
   1               5                  10                  15    
 Arg His Ser Trp Glu Met Ser Glu Phe His Asn Tyr Asn Leu Asp Leu
              20                  25                  30        
 Lys Lys Ser Asp Phe Ser Thr Arg Trp Gln Lys Gln Arg Cys Pro Val
          35                  40                  45            
 Val Lys Ser Lys Cys Arg Glu Asn Ala Ser Pro Phe Phe Phe Cys Cys
      50                  55                  60                
 Phe Ile Ala Val Ala Met Gly Ile Arg Phe Ile Ile Met Val Ala Ile
  65                  70                  75                  80
 Trp Ser Ala Val Phe Leu Asn Ser Leu Phe Asn Gln Glu Val Gln Ile
                  85                  90                  95    
 Pro Leu Thr Glu Ser Tyr Cys Gly Pro Cys Pro Lys Asn Trp Ile Cys
             100                 105                 110        
 Tyr Lys Asn Asn Cys Tyr Gln Phe Phe Asp Glu Ser Lys Asn Trp Tyr
         115                 120                 125            
 Glu Ser Gln Ala Ser Cys Met Ser Gln Asn Ala Ser Leu Leu Lys Val
     130                 135                 140                
 Tyr Ser Lys Glu Asp Gln Asp Leu Leu Lys Leu Val Lys Ser Tyr His
 145                 150                 155                 160
 Trp Met Gly Leu Val His Ile Pro Thr Asn Gly Ser Trp Gln Trp Glu
                 165                 170                 175    
 Asp Gly Ser Ile Leu Ser Pro Asn Leu Leu Thr Ile Ile Glu Met Gln
             180                 185                 190        
 Lys Gly Asp Cys Ala Leu Tyr Ala Ser Ser Phe Lys Gly Tyr Ile Glu
         195                 200                 205            
 Asn Cys Ser Thr Pro Asn Thr Tyr Ile Cys Met Gln Arg Thr Val
     210                 215                 220            



      <210> 2632
      <211> 117
      <212> PRT
      <213> Homo sapiens


      <400> 2632
 Val Gly Glu Arg Leu Thr Leu Pro Gly Leu Val Ser Ala Asp Asn Gly
   1               5                  10                  15    
 Thr Tyr Thr Cys Glu Ala Ser Asn Lys His Gly His Ala Arg Ala Leu
              20                  25                  30        
 Tyr Val Leu Val Val Tyr Asp Pro Gly Ala Val Val Glu Ala Gln Thr
          35                  40                  45            
 Ser Val Pro Tyr Ala Ile Val Gly Gly Ile Leu Ala Leu Leu Val Phe
      50                  55                  60                
 Leu Ile Ile Cys Val Leu Val Gly Met Val Trp Cys Ser Val Arg Gln
  65                  70                  75                  80
 Lys Gly Ser Tyr Leu Thr His Glu Ala Ser Gly Leu Asp Glu Gln Gly
                  85                  90                  95    
 Glu Ala Arg Glu Ala Phe Leu Asn Gly Ser Asp Gly His Lys Arg Lys
             100                 105                 110        
 Glu Glu Phe Phe Ile
         115        



      <210> 2633
      <211> 174
      <212> PRT
      <213> Homo sapiens


      <400> 2633
 Cys Cys Cys Asn Val Phe Asn Cys Phe Ser Leu Ser Leu Gln Thr Trp
   1               5                  10                  15    
 Ala Leu His Ser Leu Ser Leu Ile Ile Asp Ser Ala Gly Pro Leu Tyr
              20                  25                  30        
 Tyr Val His Val Glu Pro Thr Leu Ser Leu Ile Ile Ile Val Val Val
          35                  40                  45            
 Asn Val Pro Pro Thr His Ala Glu Val His Gln Ser Leu Gly Arg Cys
      50                  55                  60                
 Leu Asn Ala Leu Ile Thr Thr Leu Gly Pro Glu Leu Gln Gly Asn Ser
  65                  70                  75                  80
 Thr Ser Ile Ser Thr Leu Arg Thr Ser Cys Leu Leu Gly Cys Ala Val
                  85                  90                  95    
 Met Gln Asp Asn Pro Asp Cys Leu Val Gln Ala Gln Ala Ile Ser Cys
             100                 105                 110        
 Leu Gln Gln Leu His Met Phe Ala Pro Arg His Val Asn Leu Ser Ser
         115                 120                 125            
 Leu Val Ser Cys Leu Cys Val Asn Leu Cys Ser Pro Tyr Leu Leu Leu
     130                 135                 140                
 Arg Arg Ala Val Leu Ala Cys Leu Arg Gln Leu Val Gln Arg Glu Ala
 145                 150                 155                 160
 Ala Glu Val Ser Glu His Ala Val Met Leu Ala Lys Asp Ser
                 165                 170                



      <210> 2634
      <211> 212
      <212> PRT
      <213> Homo sapiens


      <400> 2634
 Glu Met Ser Glu Arg Trp Lys Arg Arg Gly Asn Ser Thr Arg Thr Ser
   1               5                  10                  15    
 Ser Leu Ala Ser Gly Ala Gly Asp Pro Glu Pro Asp Leu Trp Ile Ile
              20                  25                  30        
 Gln Pro Gln Glu Leu Val Leu Gly Thr Thr Gly Asp Thr Val Phe Leu
          35                  40                  45            
 Asn Cys Thr Val Leu Gly Asp Gly Pro Pro Gly Pro Ile Arg Trp Phe
      50                  55                  60                
 Gln Gly Ala Gly Leu Ser Arg Glu Ala Ile Tyr Asn Phe Gly Gly Ile
  65                  70                  75                  80
 Ser His Pro Lys Ala Thr Ala Val Gln Ala Ser Asn Asn Asp Phe Ser
                  85                  90                  95    
 Ile Leu Leu Gln Asn Val Ser Ser Glu Asp Ala Gly Thr Tyr Tyr Cys
             100                 105                 110        
 Val Lys Phe Gln Arg Lys Pro Asn Arg Gln Tyr Leu Ser Gly Gln Gly
         115                 120                 125            
 Thr Ser Leu Lys Val Lys Ala Lys Ser Thr Ser Ser Lys Glu Ala Glu
     130                 135                 140                
 Phe Thr Ser Glu Pro Ala Thr Glu Met Ser Pro Thr Gly Leu Leu Val
 145                 150                 155                 160
 Val Phe Ala Pro Val Val Leu Gly Leu Lys Ala Ile Thr Leu Ala Ala
                 165                 170                 175    
 Leu Leu Leu Ala Leu Ala Thr Ser Arg Arg Ser Pro Gly Gln Glu Asp
             180                 185                 190        
 Val Lys Thr Thr Gly Pro Ala Gly Ala Met Asn Thr Leu Ser Trp Ser
         195                 200                 205            
 Lys Gly Gln Glu
     210        



      <210> 2635
      <211> 164
      <212> PRT
      <213> Homo sapiens


      <400> 2635
 Lys Ile Lys Ala Lys Asn Leu Thr Asn Tyr Asp Leu Cys Ser Ile Phe
   1               5                  10                  15    
 Leu Gly Thr Ser Thr Leu Leu Val Trp Val Gly Val Ile Arg Tyr Leu
              20                  25                  30        
 Gly Tyr Phe Gln Ala Tyr Asn Val Leu Ile Leu Thr Met Gln Ala Ser
          35                  40                  45            
 Leu Pro Lys Val Leu Arg Phe Cys Ala Cys Ala Gly Met Ile Tyr Leu
      50                  55                  60                
 Gly Tyr Thr Phe Cys Gly Trp Ile Val Leu Gly Pro Tyr His Asp Lys
  65                  70                  75                  80
 Phe Glu Asn Leu Asn Thr Val Ala Glu Cys Leu Phe Ser Leu Val Asn
                  85                  90                  95    
 Gly Asp Asp Met Phe Ala Thr Phe Ala Gln Ile Gln Gln Lys Ser Ile
             100                 105                 110        
 Leu Val Trp Leu Phe Ser Arg Leu Tyr Leu Tyr Ser Phe Ile Ser Leu
         115                 120                 125            
 Phe Ile Tyr Met Ile Leu Ser Leu Phe Ile Ala Leu Ile Thr Asp Ser
     130                 135                 140                
 Tyr Asp Thr Ile Lys Lys Phe Gln Gln Asn Gly Phe Pro Glu Thr Asp
 145                 150                 155                 160
 Leu Gln Glu Phe
                



      <210> 2636
      <211> 72
      <212> PRT
      <213> Homo sapiens


      <400> 2636
 Gly Gly Ile Pro Pro Ala Ala Val Arg Gly Gly Arg Ser Trp Leu Arg
   1               5                  10                  15    
 Asp Val Leu Ser Arg Leu Ala Ala Ala Gly Arg Arg Arg Arg Gly Thr
              20                  25                  30        
 Arg Arg Gly Arg Gly Arg Ala Gly Gly Ala Gly Gly Gly Arg Asp Arg
          35                  40                  45            
 Val Gly Ser Arg Arg Glu Pro Ala Ala Ala Arg Thr Ala Ala Glu Gly
      50                  55                  60                
 Glu Arg Ala Val Arg Gly Lys Cys
  65                  70        



      <210> 2637
      <211> 126
      <212> PRT
      <213> Homo sapiens


      <400> 2637
 Arg Cys Pro Ser Pro Gln Pro Gly Cys Pro Pro Ala Tyr Thr Gly Thr
   1               5                  10                  15    
 Val Leu Glu Gln Thr Leu Ser Pro Leu Trp Asp Glu Leu Leu Val Phe
              20                  25                  30        
 Glu Gln Leu Ile Val Asp Gly Arg Arg Glu His Leu Gln Glu Glu Pro
          35                  40                  45            
 Pro Leu Val Ile Ile Asn Val Phe Asp His Asn Lys Phe Gly Pro Pro
      50                  55                  60                
 Val Phe Leu Gly Arg Ala Leu Ala Ala Pro Arg Val Lys Leu Met Glu
  65                  70                  75                  80
 Asp Pro Tyr Gln Arg Pro Glu Leu Gln Phe Phe Pro Leu Arg Lys Gly
                  85                  90                  95    
 Pro Trp Ala Ala Gly Glu Leu Ile Ala Ala Phe Gln Leu Ile Glu Leu
             100                 105                 110        
 Asp Tyr Ser Gly Arg Leu Glu Val Ser Met Pro Trp Arg Gly
         115                 120                 125    



      <210> 2638
      <211> 261
      <212> PRT
      <213> Homo sapiens


      <400> 2638
 Gly Pro Arg Ala Arg Pro Pro Val Leu Thr Arg Arg Ser Ser Trp Pro
   1               5                  10                  15    
 Pro Arg Arg Ser Arg Gly Ser Met Arg Phe Lys Asn Arg Phe Gln Arg
              20                  25                  30        
 Phe Met Asn His Arg Ala Pro Ala Asn Gly Arg Tyr Lys Pro Thr Cys
          35                  40                  45            
 Tyr Glu His Ala Ala Asn Cys Tyr Thr His Ala Phe Leu Ile Val Pro
      50                  55                  60                
 Ala Ile Val Gly Ser Ala Leu Leu His Arg Leu Ser Asp Asp Cys Trp
  65                  70                  75                  80
 Glu Lys Ile Thr Ala Trp Ile Tyr Gly Met Gly Leu Cys Ala Leu Phe
                  85                  90                  95    
 Ile Val Ser Thr Val Phe His Ile Val Ser Trp Lys Lys Ser His Leu
             100                 105                 110        
 Arg Thr Val Glu His Cys Phe His Met Cys Asp Arg Met Val Ile Tyr
         115                 120                 125            
 Phe Phe Ile Ala Ala Ser Tyr Ala Pro Trp Leu Asn Leu Arg Glu Leu
     130                 135                 140                
 Gly Pro Leu Ala Ser His Met Arg Trp Phe Ile Trp Leu Met Ala Ala
 145                 150                 155                 160
 Gly Gly Thr Ile Tyr Val Phe Leu Tyr His Glu Lys Tyr Lys Gly Val
                 165                 170                 175    
 Glu Leu Phe Phe Tyr Leu Thr Met Gly Phe Ser Pro Ala Leu Val Val
             180                 185                 190        
 Thr Ser Met Asn Asn Thr Asp Gly Leu Gln Glu Leu Ala Cys Gly Gly
         195                 200                 205            
 Leu Ile Tyr Cys Leu Gly Val Val Phe Phe Lys Ser Asp Gly Ile Ile
     210                 215                 220                
 Pro Phe Ala His Ala Ile Trp His Leu Phe Val Ala Thr Ala Ala Ala
 225                 230                 235                 240
 Val His Tyr Tyr Ala Ile Trp Lys Tyr Leu Tyr Arg Ser Pro Thr Asp
                 245                 250                 255    
 Phe Met Arg His Leu
             260    



      <210> 2639
      <211> 79
      <212> PRT
      <213> Homo sapiens


      <400> 2639
 Lys Thr Gln Glu Thr His Ile Tyr Ile Ser Glu His Ile Phe Phe Pro
   1               5                  10                  15    
 Phe Leu Gln Gly Phe Gly Asn Leu Pro Ile Cys Met Ala Lys Thr Asp
              20                  25                  30        
 Leu Ser Leu Ser His Gln Pro Asp Lys Lys Gly Val Pro Ser Asp Phe
          35                  40                  45            
 Ile Leu Pro Ile Ser Asp Val Arg Ala Ser Ile Gly Ala Gly Phe Ile
      50                  55                  60                
 Tyr Pro Leu Val Gly Thr Gly Ser Arg Glu Ser Pro Leu Trp Leu
  65                  70                  75                



      <210> 2640
      <211> 691
      <212> PRT
      <213> Homo sapiens


      <400> 2640
 Met Lys Pro Cys Ala His Ser Trp Asn Ala Glu Leu Ser Arg Asn Ile
   1               5                  10                  15    
 Ile Arg His Ser Phe Asn Leu Val Met Val Ala Ala Ser Gln Val Ala
              20                  25                  30        
 Val Ser Gln Leu Leu Gly Ser Tyr Glu Ile Leu Leu Leu Val Ser Ile
          35                  40                  45            
 Glu Leu Met Phe Cys Phe Gly Leu Gly Tyr Phe Phe Ile Pro Met Gln
      50                  55                  60                
 Glu Trp Pro Asn Thr Tyr Gly Glu Arg Val Phe Val Asp Val Glu Ser
  65                  70                  75                  80
 Ser Val Phe Lys Trp Asn His Lys Cys Leu His Lys Thr Glu Ala Glu
                  85                  90                  95    
 Arg Asp Tyr Thr Lys Lys Arg Leu Lys Leu Cys Gly His Lys Pro Gly
             100                 105                 110        
 Asn Ala Val Gly Gln Gln Lys Leu Glu Glu Ala Arg Asn Arg Phe Phe
         115                 120                 125            
 Thr Arg Ala Pro Gly Gly Ser Ala Ala Leu Pro Thr Leu Arg Phe Gln
     130                 135                 140                
 Pro Ser Asp Thr Asp Phe Arg Leu Leu Ala Ser Arg Thr Ile Leu Thr
 145                 150                 155                 160
 Phe Glu Thr Lys Asn Pro Ser Glu Leu Ala Glu Arg Leu Arg Ser Val
                 165                 170                 175    
 Cys Gly Asn Gln Ser Asn Ala Tyr Ala Arg Leu Leu Glu Tyr Arg Leu
             180                 185                 190        
 Asn Ala Leu Arg Gly Leu Trp Asn Ala Gln Arg Gln Leu Ala Leu Glu
         195                 200                 205            
 Glu Gln His Glu Arg Glu Ser Ser Gly Asp Glu Glu Thr Leu Ala Leu
     210                 215                 220                
 Leu Lys Arg Gln Gly Leu Leu Gln Gln Pro Glu Gln Ala Pro Phe Thr
 225                 230                 235                 240
 Ser Arg Met Gly Leu Leu Leu Val Phe Pro Leu Ile Gln Ser Gln Ser
                 245                 250                 255    
 Arg Thr Asp Pro Ser Leu Cys Asn Ile Thr Ala Glu Val Leu Leu Asn
             260                 265                 270        
 Cys Leu Arg Asp Cys Gln Pro Leu Ser Leu Thr Lys Glu Pro Ala Asp
         275                 280                 285            
 Cys Leu Asn Gly Ile Glu Thr Leu Leu Cys Ser Trp Leu Glu Glu Thr
     290                 295                 300                
 Ser Asp Thr Gly Arg His Ile Pro His Lys Gln Lys Glu Asn Ala Ala
 305                 310                 315                 320
 Ala Ala Leu Val Ala Leu Ala Cys Ala Arg Gly Phe Val Tyr Cys Arg
                 325                 330                 335    
 Asn Glu Glu Leu Glu Pro Gly Trp Val Ala Phe Gly Ser Gly Ser Leu
             340                 345                 350        
 Leu His Arg Pro Val Ser Phe Asp Asn Lys Pro His Ser Leu Phe Gln
         355                 360                 365            
 Val Ile Asp Gln Asn Thr Leu Gln Val Cys Gln Val Val Pro Met Pro
     370                 375                 380                
 Ala Asn His Leu Pro Ile Gly Ser Thr Met Ser Thr Val His Leu Ser
 385                 390                 395                 400
 Ser Asp Gly Thr Tyr Phe Tyr Trp Ile Trp Ser Pro Ala Ser Leu Asn
                 405                 410                 415    
 Glu Lys Thr Pro Lys Gly His Ser Val Phe Met Asp Ile Phe Glu Leu
             420                 425                 430        
 Val Thr Leu Lys Gly Lys Lys Ala Lys Gly Lys Lys Val Ala Pro Ala
         435                 440                 445            
 Pro Ala Val Val Lys Lys Gln Glu Ala Lys Lys Val Val Asn Ser Leu
     450                 455                 460                
 Phe Glu Lys Arg Asp Ile Gln Pro Lys Arg Glu Leu Thr Tyr Phe Val
 465                 470                 475                 480
 Lys Trp Pro Arg Tyr Val Arg Leu Gln Gln Gln Arg Ala Ile Leu Tyr
                 485                 490                 495    
 Lys Gln Leu Lys Val Pro Pro Ala Ile Asn Gln Phe Thr Gln Ala Leu
             500                 505                 510        
 Asn Cys Gln Thr Val Thr Gln Leu Leu Lys Leu Ala His Lys Tyr Arg
         515                 520                 525            
 Pro Glu Thr Lys Gln Glu Lys Lys Gln Arg Leu Leu Ala Gln Ala Glu
     530                 535                 540                
 Lys Lys Ala Ala Gly Lys Gly Gly Val Pro Thr Lys Arg Pro Pro Ala
 545                 550                 555                 560
 Leu Arg Ala Gly Val Asn Thr Ile Thr Thr Leu Val Glu Asn Lys Lys
                 565                 570                 575    
 Ala Gln Leu Val Val Ile Ala His Asp Val Asp Ser Ile Glu Leu Val
             580                 585                 590        
 Val Phe Leu Pro Ala Leu Cys Cys Lys Met Gly Val Pro Tyr Cys Ile
         595                 600                 605            
 Ile Lys Gly Lys Ala Arg Leu Gly Arg Leu Val His Arg Lys Thr Cys
     610                 615                 620                
 Thr Thr Val Ala Phe Thr Gln Val Asn Leu Glu Asp Lys Gly Ala Leu
 625                 630                 635                 640
 Ala Lys Leu Val Glu Gly Ile Arg Thr Asn Asp Asn Asp Arg Tyr Asp
                 645                 650                 655    
 Glu Ile Cys Cys His Trp Gly Gly Asn Ile Leu Gly Pro Lys Ser Val
             660                 665                 670        
 Ala Cys Ile Ala Lys Leu Glu Lys Ala Lys Ala Lys Glu Leu Ala Thr
         675                 680                 685            
 Lys Leu Gly
     690    



      <210> 2641
      <211> 535
      <212> PRT
      <213> Homo sapiens


      <400> 2641
 Ser Glu Leu Leu Leu Thr Phe Ser Phe Arg Leu Arg Met Thr Gln Asn
   1               5                  10                  15    
 Lys Leu Lys Leu Cys Ser Lys Ala Asn Val Tyr Thr Glu Val Pro Asp
              20                  25                  30        
 Gly Gly Trp Gly Trp Ala Val Ala Val Ser Phe Phe Phe Val Glu Val
          35                  40                  45            
 Phe Thr Tyr Gly Ile Ile Lys Thr Phe Gly Val Phe Phe Asn Asp Leu
      50                  55                  60                
 Met Asp Ser Phe Asn Glu Ser Asn Ser Arg Ile Ser Trp Ile Ile Ser
  65                  70                  75                  80
 Ile Cys Val Phe Val Leu Thr Phe Ser Ala Pro Leu Ala Thr Val Leu
                  85                  90                  95    
 Ser Asn Arg Phe Gly His Arg Leu Val Val Met Leu Gly Gly Leu Leu
             100                 105                 110        
 Val Ser Thr Gly Met Val Ala Ala Ser Phe Ser Gln Glu Val Ser His
         115                 120                 125            
 Met Tyr Val Ala Ile Gly Ile Ile Ser Gly Leu Gly Tyr Cys Phe Ser
     130                 135                 140                
 Phe Leu Pro Thr Val Thr Ile Leu Ser Gln Tyr Phe Gly Lys Arg Arg
 145                 150                 155                 160
 Ser Ile Val Thr Ala Val Ala Ser Thr Gly Glu Cys Phe Ala Val Phe
                 165                 170                 175    
 Ala Phe Ala Pro Ala Ile Met Ala Leu Lys Glu Arg Ile Gly Trp Arg
             180                 185                 190        
 Tyr Ser Leu Leu Phe Val Gly Leu Leu Gln Leu Asn Ile Val Ile Phe
         195                 200                 205            
 Gly Ala Leu Leu Arg Pro Ile Phe Ile Arg Gly Pro Ala Ser Pro Lys
     210                 215                 220                
 Ile Val Ile Gln Glu Asn Arg Lys Glu Ala Gln Tyr Met Leu Glu Asn
 225                 230                 235                 240
 Glu Lys Thr Arg Thr Ser Ile Asp Ser Ile Asp Ser Gly Val Glu Leu
                 245                 250                 255    
 Thr Thr Ser Pro Lys Asn Val Pro Thr His Thr Asn Leu Glu Leu Glu
             260                 265                 270        
 Pro Lys Ala Asp Met Gln Gln Val Leu Val Lys Thr Ser Pro Arg Pro
         275                 280                 285            
 Ser Glu Lys Lys Ala Pro Leu Leu Asp Phe Ser Ile Leu Lys Glu Lys
     290                 295                 300                
 Ser Phe Ile Cys Tyr Ala Leu Phe Gly Leu Phe Ala Thr Leu Gly Phe
 305                 310                 315                 320
 Phe Ala Pro Ser Leu Tyr Ile Ile Pro Leu Gly Ile Ser Leu Gly Ile
                 325                 330                 335    
 Asp Gln Asp Arg Ala Ala Phe Leu Leu Ser Thr Met Ala Ile Ala Glu
             340                 345                 350        
 Val Phe Gly Arg Ile Gly Ala Gly Phe Val Leu Asn Arg Glu Pro Ile
         355                 360                 365            
 Arg Lys Ile Tyr Ile Glu Leu Ile Cys Val Ile Leu Leu Thr Val Ser
     370                 375                 380                
 Leu Phe Ala Phe Thr Phe Ala Thr Glu Phe Trp Gly Leu Met Ser Cys
 385                 390                 395                 400
 Ser Ile Phe Phe Gly Phe Met Val Gly Thr Ile Gly Gly Leu Thr Phe
                 405                 410                 415    
 His Cys Leu Leu Arg Met Met Ser Trp Ala Leu Gln Lys Met Ser Ser
             420                 425                 430        
 Ala Ala Gly Val Tyr Ile Phe Ile Gln Ser Ile Ala Gly Leu Ala Gly
         435                 440                 445            
 Pro Pro Leu Ala Gly Leu Leu Val Asp Gln Ser Lys Ile Tyr Ser Arg
     450                 455                 460                
 Ala Phe Tyr Ser Cys Ala Ala Gly Met Ala Leu Ala Ala Val Cys Leu
 465                 470                 475                 480
 Ala Leu Val Arg Pro Cys Lys Met Gly Leu Cys Gln His His His Ser
                 485                 490                 495    
 Gly Glu Thr Lys Val Val Ser His Arg Gly Lys Thr Leu Gln Asp Ile
             500                 505                 510        
 Pro Glu Asp Phe Leu Glu Met Asp Leu Ala Lys Asn Glu His Arg Val
         515                 520                 525            
 His Val Gln Met Glu Pro Val
     530                 535



      <210> 2642
      <211> 173
      <212> PRT
      <213> Homo sapiens


      <400> 2642
 Pro Pro Arg Ala Ala Glu Leu Ala Pro Ser Pro Pro Ala Asp Met Phe
   1               5                  10                  15    
 Glu Ser Lys Asn Gly Pro Glu Tyr Ala Ser Phe Phe Pro Val Met Gly
              20                  25                  30        
 Ala Ser Ala Ala Met Val Phe Ser Ala Leu Gly Pro Ala Tyr Gly Thr
          35                  40                  45            
 Thr Lys Ser Gly Thr Gly Ile Ser Ala Met Ser Val Ile Arg Pro Glu
      50                  55                  60                
 Gln Ile Met Lys Ser Ile Ile Pro Val Val Met Ala Gly Ile Ile Ala
  65                  70                  75                  80
 Ile Ser Gly Leu Val Val Ala Val Leu Ile Ala Asn Ser Leu Glu Cys
                  85                  90                  95    
 Ser Val Tyr Ala Asp Asp Leu Glu Met Ser Phe Leu Phe Pro Arg Met
             100                 105                 110        
 Phe Ile Tyr Lys Asp Leu Ala Cys Ser Cys Val Ser Gly Thr Ala Leu
         115                 120                 125            
 Val Ser Gln Leu Phe Ile Thr Leu Val Arg Gly Ser Pro Cys Gly Phe
     130                 135                 140                
 Leu Leu Phe Arg Leu Pro Gly Trp Asn Arg Pro Pro Arg Arg Ala Arg
 145                 150                 155                 160
 Gly Pro Ala Arg Asn Cys Val Pro Gln Ser Phe Trp Met
                 165                 170            



      <210> 2643
      <211> 148
      <212> PRT
      <213> Homo sapiens


      <400> 2643
 His Ala Ser Gly Phe Val Val Gln Gly Ser Asn Gly Glu Phe Pro Phe
   1               5                  10                  15    
 Leu Thr Ser Ser Glu Arg Leu Glu Val Val Ser Arg Val Arg Gln Ala
              20                  25                  30        
 Met Pro Met Asn Arg Leu Leu Leu Ala Gly Ser Gly Cys Glu Ser Thr
          35                  40                  45            
 Gln Ala Thr Val Glu Met Thr Val Ser Met Ala Gln Val Gly Ala Asp
      50                  55                  60                
 Ala Ala Met Val Val Thr Pro Cys Tyr Tyr Arg Gly Arg Met Ser Ser
  65                  70                  75                  80
 Ala Ala Leu Ile His His Tyr Thr Lys Val Ala Asp Leu Ser Pro Ile
                  85                  90                  95    
 Pro Val Val Leu Tyr Ser Val Pro Ala Asn Thr Gly Leu Asp Leu Pro
             100                 105                 110        
 Val Asp Ala Val Val Thr Leu Ser Gln His Pro Asn Ile Val Gly Met
         115                 120                 125            
 Lys Asp Ser Gly Gly Asp Val Thr Arg Ile Gly Leu Ile Val His Lys
     130                 135                 140                
 Thr Gln Glu Ala
 145            



      <210> 2644
      <211> 195
      <212> PRT
      <213> Homo sapiens


      <400> 2644
 His Thr His Lys Leu Val Ala Pro Arg Pro Gly Leu Pro Pro Thr Ser
   1               5                  10                  15    
 Gln Trp Pro Arg Asp Ala Gly Arg Gln Ala Ser Gly Gly Leu Pro Ser
              20                  25                  30        
 Leu Ser Thr Gly Pro Pro Lys Gly Pro Arg Asp Gly Leu Ala Arg Gly
          35                  40                  45            
 His Pro Ala Glu Trp Leu Ala Gly Ser Pro Gly Asn Asn Ser Pro Thr
      50                  55                  60                
 Gln Gly Ser Leu Pro Pro Gln Leu Asp Leu Tyr Ala Gly Ala Leu Phe
  65                  70                  75                  80
 Val His Ile Cys Leu Gly Trp Asn Phe Tyr Leu Ser Thr Ile Leu Thr
                  85                  90                  95    
 Leu Gly Ile Thr Ala Leu Tyr Thr Ile Ala Gly Met Val Pro Ala Ala
             100                 105                 110        
 Gly Arg Ser Thr Gln Gly Thr Cys Lys Gly Val Arg Arg Pro Pro Pro
         115                 120                 125            
 Pro Thr Gly Pro Arg Glu Gln Pro Arg Lys Trp Pro Gln Gln Glu Pro
     130                 135                 140                
 Gln Lys Phe Leu Pro Val Ser Leu Leu Pro Gly Ala Arg Ala Pro Ser
 145                 150                 155                 160
 Ser Asn Leu Ala Ser Thr Gly Arg Gly Pro Gly Cys Cys Asn Leu His
                 165                 170                 175    
 Gly Arg Pro Ala Asp Ala His His Gly Gly Gly Gly Cys His Pro Asp
             180                 185                 190        
 Asn Gln Arg
         195



      <210> 2645
      <211> 375
      <212> PRT
      <213> Homo sapiens


      <400> 2645
 Tyr Asn Arg Ala Met Phe His Pro His Ala Val Asn Lys Ile Ala Leu
   1               5                  10                  15    
 Ser Leu Asn Asn Lys Asn Pro Arg Ser Lys Val Leu Phe Leu Glu Leu
              20                  25                  30        
 Leu Ala Ala Val Cys Leu Val Arg Gly Gly His Lys Leu Phe Tyr Leu
          35                  40                  45            
 Ala Phe Asp Asn Phe Lys Glu Val Cys Gly Glu Lys Gln Arg Phe Glu
      50                  55                  60                
 Lys Leu Met Glu His Phe Arg Asn Glu Asp Asn Asn Ile Asp Phe Met
  65                  70                  75                  80
 Val Ala Ser Met Gln Phe Ile Asn Ile Val Val His Ser Val Glu Asp
                  85                  90                  95    
 Met Asn Phe Arg Val His Leu Gln Tyr Glu Phe Thr Lys Leu Gly Leu
             100                 105                 110        
 Asp Glu Tyr Leu Asp Lys Leu Lys His Thr Glu Ser Asp Lys Leu Gln
         115                 120                 125            
 Val Gln Ile Gln Ala Tyr Leu Asp Asn Val Phe Asp Val Gly Ala Leu
     130                 135                 140                
 Leu Glu Asp Ala Glu Thr Lys Asn Ala Ala Leu Glu Arg Val Glu Glu
 145                 150                 155                 160
 Leu Glu Glu Asn Ile Ser His Leu Ser Glu Lys Leu Gln Asp Thr Glu
                 165                 170                 175    
 Asn Glu Ala Met Ser Lys Ile Val Glu Leu Glu Lys Gln Leu Met Gln
             180                 185                 190        
 Arg Asn Lys Glu Leu Asp Val Val Arg Glu Ile Tyr Lys Asp Ala Asn
         195                 200                 205            
 Thr Gln Val His Thr Leu Arg Lys Met Val Lys Glu Lys Glu Glu Ala
     210                 215                 220                
 Ile Gln Arg Gln Ser Thr Leu Glu Lys Lys Ile His Glu Leu Glu Lys
 225                 230                 235                 240
 Gln Gly Thr Ile Lys Ile Gln Lys Lys Gly Asp Gly Asp Ile Ala Ile
                 245                 250                 255    
 Leu Pro Val Val Ala Ser Gly Thr Leu Ser Met Gly Ser Glu Val Val
             260                 265                 270        
 Ala Gly Asn Ser Val Gly Pro Thr Met Gly Ala Ala Ser Ser Gly Pro
         275                 280                 285            
 Leu Pro Pro Pro Pro Pro Pro Leu Pro Pro Ser Ser Asp Thr Pro Glu
     290                 295                 300                
 Thr Val Gln Asn Gly Pro Val Thr Pro Pro Met Pro Pro Pro Pro Thr
 305                 310                 315                 320
 Pro Pro Pro Pro Pro Pro Pro Pro Pro Pro Pro Pro Pro Pro Pro Pro
                 325                 330                 335    
 Leu Pro Gly Pro Ala Ala Glu Thr Val Pro Ala Pro Pro Leu Ala Pro
             340                 345                 350        
 Pro Leu Pro Ser Ala Pro Pro Leu Pro Gly Thr Ser Ser Pro Thr Val
         355                 360                 365            
 Val Phe Asn Ser Gly Leu Ala
     370                 375



      <210> 2646
      <211> 317
      <212> PRT
      <213> Homo sapiens


      <400> 2646
 Asn Ser Ala Lys Lys Asn Val Ser Ser Pro Thr Ser Ser Asn Lys Glu
   1               5                  10                  15    
 Val Val Met Arg Asn Asp Gln Asn Asn Gly Asp Met Lys Pro Phe Gln
              20                  25                  30        
 Asn Phe Thr Thr Ile Pro Ile Thr Gln Ala Leu Asn Tyr Asn Leu Ser
          35                  40                  45            
 Lys Glu Gly His Leu Glu Lys Glu Pro Trp Asn Ala Phe Ser His His
      50                  55                  60                
 Gly Pro Val Asn Val Ser Ile Asn Gly Ile Pro Cys Ile Leu Phe Trp
  65                  70                  75                  80
 Ala Lys Arg Ile Met Ile Lys Phe Lys Asn Gln Thr Trp Leu Asp Leu
                  85                  90                  95    
 Thr Asp Glu Pro Phe Gly Gln Lys Val Thr Val Asp Pro Asp Asn Ser
             100                 105                 110        
 Asn Cys Ser Glu Glu Ser Ala Arg Leu Ser Leu Lys Leu Gly Asp Ala
         115                 120                 125            
 Gly Asn Pro Arg Ser Leu Ala Ile Arg Phe Ile Leu Thr Asn Tyr Asn
     130                 135                 140                
 Lys Leu Ser Ile Gln Ser Trp Phe Ser Leu Arg Arg Val Glu Ile Ile
 145                 150                 155                 160
 Ser Asn Asn Ser Ile Gln Ala Val Phe Asn Pro Thr Gly Val Tyr Ala
                 165                 170                 175    
 Pro Ser Gly Tyr Ser Tyr Arg Cys Gln Arg Val Gly Ser Leu Gln Gln
             180                 185                 190        
 Asp Gln Ala Leu Leu Leu Pro Ser Asp Thr Asp Asp Gly Ser Ser Leu
         195                 200                 205            
 Trp Glu Val Thr Phe Ile Asp Phe Gln Ile Gln Gly Phe Ala Ile Lys
     210                 215                 220                
 Gly Gly Arg Phe Thr Lys Ala Gln Asp Cys Ala Ser Ser Phe Ser Pro
 225                 230                 235                 240
 Ala Phe Leu Ile Gly Leu Ala Met Ser Leu Ile Leu Leu Leu Val Leu
                 245                 250                 255    
 Ala Tyr Ala Leu His Met Leu Ile Tyr Leu Arg Tyr Leu Asp Gln Gln
             260                 265                 270        
 Tyr Asp Leu Ile Ala Ser Pro Ala His Phe Ser Gln Leu Lys Ala Arg
         275                 280                 285            
 Asp Thr Ala Glu Glu Lys Glu Leu Leu Arg Ser Gln Gly Ala Glu Cys
     290                 295                 300                
 Tyr Lys Leu Arg Ser Gln Gln Ile Ser Lys Ile Tyr Val
 305                 310                 315        



      <210> 2647
      <211> 334
      <212> PRT
      <213> Homo sapiens


      <400> 2647
 Arg Arg Gly Ile Arg Asp Ser Gly Ile Glu Tyr Leu Leu Asp Gln Thr
   1               5                  10                  15    
 Asp Val Leu Val Val Gly Val Leu Gly Leu Gln Gly Thr Gly Lys Ser
              20                  25                  30        
 Met Val Met Ser Leu Leu Ser Ala Asn Thr Pro Glu Glu Asp Gln Arg
          35                  40                  45            
 Thr Tyr Val Phe Arg Ala Gln Ser Ala Glu Met Lys Glu Arg Gly Gly
      50                  55                  60                
 Asn Gln Thr Ser Gly Ile Asp Phe Phe Ile Thr Gln Glu Arg Ile Val
  65                  70                  75                  80
 Phe Leu Asp Thr Gln Pro Ile Leu Ser Pro Ser Ile Leu Asp His Leu
                  85                  90                  95    
 Ile Asn Asn Asp Arg Lys Leu Pro Pro Glu Tyr Asn Leu Pro His Thr
             100                 105                 110        
 Tyr Val Glu Met Gln Ser Leu Gln Ile Ala Ala Phe Leu Phe Thr Val
         115                 120                 125            
 Cys His Val Val Ile Val Val Gln Asp Trp Phe Thr Asp Leu Ser Leu
     130                 135                 140                
 Tyr Arg Phe Leu Gln Thr Ala Glu Met Val Lys Pro Ser Thr Pro Ser
 145                 150                 155                 160
 Pro Ser His Glu Ser Ser Ser Ser Ser Gly Ser Asp Glu Gly Thr Glu
                 165                 170                 175    
 Tyr Tyr Pro His Leu Val Phe Leu Gln Asn Lys Ala Arg Arg Glu Asp
             180                 185                 190        
 Phe Cys Pro Arg Lys Leu Arg Gln Met His Leu Met Ile Asp Gln Leu
         195                 200                 205            
 Met Ala His Ser His Leu Arg Tyr Lys Gly Thr Leu Ser Met Leu Gln
     210                 215                 220                
 Cys Asn Val Phe Pro Gly Leu Pro Pro Asp Phe Leu Asp Ser Glu Val
 225                 230                 235                 240
 Asn Leu Phe Leu Val Pro Phe Met Asp Ser Glu Ala Glu Ser Glu Asn
                 245                 250                 255    
 Pro Pro Arg Ala Gly Pro Gly Ser Ser Pro Leu Phe Ser Leu Leu Pro
             260                 265                 270        
 Gly Tyr Arg Gly His Pro Ser Phe Gln Ser Leu Val Ser Lys Leu Arg
         275                 280                 285            
 Ser Gln Val Met Ser Met Ala Arg Pro Gln Leu Ser His Thr Ile Leu
     290                 295                 300                
 Thr Glu Lys Asn Trp Phe His Tyr Ala Ala Arg Ile Trp Asp Gly Val
 305                 310                 315                 320
 Arg Lys Ser Ser Ala Leu Ala Glu Tyr Ser Arg Leu Leu Ala
                 325                 330                



      <210> 2648
      <211> 314
      <212> PRT
      <213> Homo sapiens

      <220>
      <221> misc_feature
      <222> (1)...(314)
      <223> Xaa = any amino acid or symbol as shown in the table 8 as set forth in Example 2


      <400> 2648
 Ile Lys Ile Arg Ser Leu Gly Cys Leu Ile Ala Ala Met Ile Leu Leu
   1               5                  10                  15    
 Ser Ser Leu Thr Ala His Pro Ile Leu Arg Leu Ile Ile Thr Met Glu
              20                  25                  30        
 Ile Ser Phe Phe Ser Phe Phe Ile Leu Leu Tyr Ser Phe Ala Ile His
          35                  40                  45            
 Arg Tyr Ile Pro Phe Ile Leu Trp Pro Ile Pro Asp Leu Phe Asn Asp
      50                  55                  60                
 Leu Ile Ala Cys Ala Phe Leu Val Gly Ala Val Val Phe Ala Val Arg
  65                  70                  75                  80
 Ser Arg Arg Ser Met Asn Leu His Tyr Leu Leu Ala Val Ile Leu Ile
                  85                  90                  95    
 Gly Ala Ala Gly Val Phe Ala Phe Ile Asp Val Cys Leu Gln Arg Asn
             100                 105                 110        
 His Phe Arg Gly Lys Lys Ala Lys Lys His Met Leu Val Pro Pro Pro
         115                 120                 125            
 Gly Lys Glu Lys Gly Pro Gln Gln Gly Lys Gly Pro Glu Pro Ala Lys
     130                 135                 140                
 Pro Pro Glu Pro Gly Lys Pro Pro Gly Pro Ala Lys Gly Lys Lys Xaa
 145                 150                 155                 160
 Leu Gly Cys Leu Ile Ala Ala Met Ile Leu Leu Ser Ser Leu Thr Ala
                 165                 170                 175    
 His Pro Ile Leu Arg Leu Ile Ile Thr Met Glu Ile Ser Phe Phe Ser
             180                 185                 190        
 Phe Phe Ile Leu Leu Tyr Ser Phe Ala Ile His Arg Tyr Ile Pro Phe
         195                 200                 205            
 Ile Leu Trp Pro Ile Pro Asp Leu Phe Asn Asp Leu Ile Ala Cys Ala
     210                 215                 220                
 Phe Leu Val Gly Ala Val Val Phe Ala Val Arg Ser Arg Arg Ser Met
 225                 230                 235                 240
 Asn Leu His Tyr Leu Leu Ala Val Ile Leu Ile Gly Ala Ala Gly Val
                 245                 250                 255    
 Phe Ala Phe Ile Asp Val Cys Leu Gln Arg Asn His Phe Arg Gly Lys
             260                 265                 270        
 Lys Ala Lys Lys His Met Leu Val Pro Pro Pro Gly Lys Glu Lys Gly
         275                 280                 285            
 Pro Gln Gln Gly Lys Gly Pro Glu Pro Ala Lys Pro Pro Glu Pro Gly
     290                 295                 300                
 Lys Pro Pro Gly Pro Ala Lys Gly Lys Lys
 305                 310                



      <210> 2649
      <211> 509
      <212> PRT
      <213> Homo sapiens


      <400> 2649
 Met Ala Ile Thr Leu Arg Glu Leu Asn Gly Leu Ser Tyr Glu Glu Ile
   1               5                  10                  15    
 Ala Ala Ile Met Asp Cys Pro Ala Leu Thr Ile Ala Gly Tyr Trp Ile
              20                  25                  30        
 Arg Val Leu Gly Met Gln Lys Glu Gln Leu Ser Ala Leu Met Asp Gly
          35                  40                  45            
 Glu Thr Leu Asp Ser Glu Leu Leu Asn Glu Leu Ala His Asn Pro Glu
      50                  55                  60                
 Met Gln Lys Thr Trp Glu Ser Tyr His Leu Ile Arg Asp Ser Met Arg
  65                  70                  75                  80
 Gly Asp Thr Pro Glu Val Leu His Phe Asp Ile Ser Ser Arg Val Met
                  85                  90                  95    
 Ala Ala Ile Glu Glu Glu Pro Val Phe Leu Arg Asp Ile Ile Cys Glu
             100                 105                 110        
 Tyr Asn Cys Ala Ser Ile Pro Tyr Glu Arg Asp Arg Ile Met Gln Ser
         115                 120                 125            
 Val Thr Lys Ile Val Asn Ala Gln Leu Ile Arg Ile Glu Leu Ala Gly
     130                 135                 140                
 Lys His Thr Ile Asp Val Leu Met Glu Arg Leu Ser Val Arg Ile Ala
 145                 150                 155                 160
 Leu Ile Lys Lys Leu Leu Arg Leu Phe Phe Pro Leu Ser Leu Arg Val
                 165                 170                 175    
 Arg Phe Leu Leu Ala Thr Ala Ala Val Val Leu Val Leu Ser Leu Ala
             180                 185                 190        
 Tyr Gly Met Val Ala Leu Ile Gly Tyr Ser Val Ser Phe Asp Lys Thr
         195                 200                 205            
 Thr Phe Arg Leu Leu Arg Gly Glu Ser Asn Leu Phe Tyr Thr Leu Ala
     210                 215                 220                
 Lys Trp Glu Asn Asn Lys Leu His Val Glu Leu Pro Glu Asn Ile Asp
 225                 230                 235                 240
 Lys Gln Ser Pro Thr Met Thr Leu Ile Tyr Asp Glu Asn Gly Gln Leu
                 245                 250                 255    
 Leu Trp Ala Gln Arg Asp Met Lys Gly Trp Thr Asn Glu Cys Ile Leu
             260                 265                 270        
 Val Leu Ser Gly Asp His Ser Ile Gln Gln Gln Leu Gln Glu Val Arg
         275                 280                 285            
 Glu Asp Asp Asp Asp Ala Glu Met Thr His Ser Val Ala Val Asn Val
     290                 295                 300                
 Tyr Pro Ala Thr Ser Arg Met Pro Lys Leu Thr Ile Val Val Val Asp
 305                 310                 315                 320
 Thr Ile Pro Val Glu Leu Lys Ser Ser Tyr Met Gly Leu Cys Gly Gln
                 325                 330                 335    
 Pro Thr Asn Lys Asp Val Leu Arg Arg Met Lys Lys Arg Tyr Pro Thr
             340                 345                 350        
 Thr Phe Val Met Val Val Met Leu Ala Ser Tyr Phe Leu Ile Ser Met
         355                 360                 365            
 Phe Gly Gly Val Met Val Phe Val Phe Gly Ile Thr Phe Pro Leu Leu
     370                 375                 380                
 Cys Met Glu Lys Ile Val Ser Thr Lys Ala Ile Leu Asp Lys Asn Thr
 385                 390                 395                 400
 Asn Gln Cys Lys Gly Met Cys Lys Gly Ile Arg Thr Leu Lys Ser Cys
                 405                 410                 415    
 Leu Cys Tyr Leu Ile Asn Gly Ser Ser Ile Val Glu Val Gln Asp Ser
             420                 425                 430        
 Trp Leu Met Gly Ala Ile Lys Phe Gln Gln Glu Ser Arg Leu Leu His
         435                 440                 445            
 His Arg Leu Leu Ser Ala Ile Arg Ile Lys Gln Lys Glu Glu Glu Glu
     450                 455                 460                
 Arg Asn Lys Lys Glu Lys Lys Asp Lys Glu Leu Glu Ser Ile Phe Pro
 465                 470                 475                 480
 Ser Tyr Gly Pro Phe His Tyr Phe Lys Ser Lys Thr Ile Lys Glu Trp
                 485                 490                 495    
 Ala Pro Phe Tyr Gly Tyr Asp Phe Tyr Pro Leu Val Leu
             500                 505                



      <210> 2650
      <211> 382
      <212> PRT
      <213> Homo sapiens


      <400> 2650
 Thr Arg Tyr Asp Pro Arg Val Arg Arg Asp Arg Cys Gly Thr Ser Asp
   1               5                  10                  15    
 Pro Tyr Val Lys Phe Lys Leu Asn Gly Lys Thr Leu Tyr Lys Ser Lys
              20                  25                  30        
 Val Ile Tyr Lys Asn Leu Asn Pro Val Trp Asp Glu Ile Val Val Leu
          35                  40                  45            
 Pro Ile Gln Ser Leu Asp Gln Lys Leu Arg Val Lys Val Tyr Asp Arg
      50                  55                  60                
 Asp Leu Thr Thr Ser Asp Phe Met Gly Ser Ala Phe Val Ile Leu Ser
  65                  70                  75                  80
 Asp Leu Glu Leu Asn Arg Thr Thr Glu His Ile Leu Lys Leu Glu Asp
                  85                  90                  95    
 Pro Asn Ser Leu Glu Asp Asp Met Gly Val Ile Val Leu Asn Leu Asn
             100                 105                 110        
 Leu Val Val Lys Gln Gly Asp Phe Lys Arg His Arg Trp Ser Asn Arg
         115                 120                 125            
 Lys Arg Leu Ser Ala Ser Lys Ser Ser Leu Ile Arg Asn Leu Arg Leu
     130                 135                 140                
 Ser Glu Ser Leu Lys Lys Asn Gln Leu Trp Asn Gly Ile Ile Ser Ile
 145                 150                 155                 160
 Thr Leu Leu Glu Gly Lys Asn Val Ser Gly Gly Ser Met Thr Glu Met
                 165                 170                 175    
 Phe Val Gln Leu Lys Leu Gly Asp Gln Arg Tyr Lys Ser Lys Thr Leu
             180                 185                 190        
 Cys Lys Ser Ala Asn Pro Gln Trp Gln Glu Gln Phe Asp Phe His Tyr
         195                 200                 205            
 Phe Ser Asp Arg Met Gly Ile Leu Asp Ile Glu Val Trp Gly Lys Asp
     210                 215                 220                
 Asn Lys Lys His Glu Glu Arg Leu Gly Thr Cys Lys Val Asp Ile Ser
 225                 230                 235                 240
 Ala Leu Pro Leu Lys Gln Ala Asn Cys Leu Glu Leu Pro Leu Asp Ser
                 245                 250                 255    
 Cys Leu Gly Ala Leu Leu Met Leu Val Thr Leu Thr Pro Cys Ala Gly
             260                 265                 270        
 Val Ser Val Ser Asp Leu Cys Val Cys Pro Leu Ala Asp Leu Ser Glu
         275                 280                 285            
 Arg Lys Gln Ile Thr Gln Arg Tyr Cys Leu Gln Asn Ser Leu Lys Asp
     290                 295                 300                
 Val Lys Asp Val Gly Ile Leu Gln Val Lys Val Leu Lys Ala Ala Asp
 305                 310                 315                 320
 Leu Leu Ala Ala Asp Phe Ser Gly Lys Ser Asp Pro Phe Cys Leu Leu
                 325                 330                 335    
 Glu Leu Gly Asn Asp Arg Leu Gln Thr His Thr Val Tyr Lys Asn Leu
             340                 345                 350        
 Asn Pro Glu Trp Asn Lys Val Phe Thr Phe Pro Ile Lys Asp Ile His
         355                 360                 365            
 Asp Val Leu Glu Val Thr Val Phe Asp Glu Asp Gly Asp Lys
     370                 375                 380        



      <210> 2651
      <211> 199
      <212> PRT
      <213> Homo sapiens

      <220>
      <221> misc_feature
      <222> (1)...(199)
      <223> Xaa = any amino acid or symbol as shown in the table 8 as set forth in Example 2


      <400> 2651
 Leu Pro Ser Leu Ser Leu Arg Leu Leu His Asn Cys Ala Pro Leu Val
   1               5                  10                  15    
 Leu Asp Lys Thr Ile Ser Phe Ile Ile Cys Ile Ile Thr Arg Pro Ser
              20                  25                  30        
 Ile Met Thr Glu Ile Arg Xaa Tyr Thr Leu His Gly Val Asn Ala Arg
          35                  40                  45            
 Asn Gln Asn Ser Arg Leu Ala Ala Thr Lys Pro Ser Ser Val Arg Ser
      50                  55                  60                
 Gly Leu Phe Gln Leu Ser Ser Ser Ser Ala Arg Gln Pro Thr Pro Gln
  65                  70                  75                  80
 Arg Pro Ala Pro Arg Ala Ala Arg Leu Pro Arg Pro Pro Pro Gly Pro
                  85                  90                  95    
 Arg Pro Pro Pro Pro Ala Thr Pro Arg Pro Pro Pro Pro Gln Leu Pro
             100                 105                 110        
 Ala Leu Pro Pro Pro Ala Ala Ala Ala Leu Arg Gly Met Pro Gly Ala
         115                 120                 125            
 Val Ala Ala Thr Ala Ala Pro Ala Pro Arg Arg Gln Glu Pro Gly Ile
     130                 135                 140                
 Pro Pro Arg Arg Ala Pro Glu Ala Pro Gly Ser Pro Ser Ser Ala Val
 145                 150                 155                 160
 Leu Pro Gly Arg Asp Gly Ala Gly Arg Ala Arg Gly Arg Ala Trp Val
                 165                 170                 175    
 Trp Val Pro Pro Arg Ala Gly Arg Arg Trp Arg Gln Val Pro Glu Arg
             180                 185                 190        
 Gly Ala His Arg Gly Ala Gln
         195                



      <210> 2652
      <211> 199
      <212> PRT
      <213> Homo sapiens

      <220>
      <221> misc_feature
      <222> (1)...(199)
      <223> Xaa = any amino acid or symbol as shown in the table 8 as set forth in Example 2


      <400> 2652
 Leu Pro Ser Leu Ser Leu Arg Leu Leu His Asn Cys Ala Pro Leu Val
   1               5                  10                  15    
 Leu Asp Lys Thr Ile Ser Phe Ile Ile Cys Ile Ile Thr Arg Pro Ser
              20                  25                  30        
 Ile Met Thr Glu Ile Arg Xaa Tyr Thr Leu His Gly Val Asn Ala Arg
          35                  40                  45            
 Asn Gln Asn Ser Arg Leu Ala Ala Thr Lys Pro Ser Ser Val Arg Ser
      50                  55                  60                
 Gly Leu Phe Gln Leu Ser Ser Ser Ser Ala Arg Gln Pro Thr Pro Gln
  65                  70                  75                  80
 Arg Pro Ala Pro Arg Ala Ala Arg Leu Pro Arg Pro Pro Pro Gly Pro
                  85                  90                  95    
 Arg Pro Pro Pro Pro Ala Thr Pro Arg Pro Pro Pro Pro Gln Leu Pro
             100                 105                 110        
 Ala Leu Pro Pro Pro Ala Ala Ala Ala Leu Arg Gly Met Pro Gly Ala
         115                 120                 125            
 Val Ala Ala Thr Ala Ala Pro Ala Pro Arg Arg Gln Glu Pro Gly Ile
     130                 135                 140                
 Pro Pro Arg Arg Ala Pro Glu Ala Pro Gly Ser Pro Ser Ser Ala Val
 145                 150                 155                 160
 Leu Pro Gly Arg Asp Gly Ala Gly Arg Ala Arg Gly Arg Ala Trp Val
                 165                 170                 175    
 Trp Val Pro Pro Arg Ala Gly Arg Arg Trp Arg Gln Val Pro Glu Arg
             180                 185                 190        
 Gly Ala His Arg Gly Ala Gln
         195                



      <210> 2653
      <211> 125
      <212> PRT
      <213> Homo sapiens


      <400> 2653
 Glu Val Ser Leu Ser Thr Val Pro Ala Ser Gly His His Ser Gly Pro
   1               5                  10                  15    
 Ser Leu His Ala Glu Asn His Thr Ser Gln Thr Phe Thr Gln His Phe
              20                  25                  30        
 Leu Pro Gln Ser Gln Lys Met His Lys Glu Glu His Glu Val Ala Val
          35                  40                  45            
 Leu Gly Ala Pro Pro Ser Thr Ile Leu Pro Arg Ser Thr Val Ile Asn
      50                  55                  60                
 Ile His Ser Glu Thr Ser Val Pro Asp His Val Val Trp Ser Leu Phe
  65                  70                  75                  80
 Asn Thr Leu Phe Leu Asn Trp Cys Cys Leu Gly Phe Ile Ala Phe Ala
                  85                  90                  95    
 Tyr Ser Val Lys Ser Met Asp Arg Lys Met Val Gly Asp Val Thr Gly
             100                 105                 110        
 Ala Gln Ala Tyr Ala Ser Thr Ala Lys Cys Leu Asn Ile
         115                 120                 125



      <210> 2654
      <211> 538
      <212> PRT
      <213> Homo sapiens


      <400> 2654
 Met Lys Asn Gly Val Gln Trp Ala Glu Leu Ala Gly His Asp Tyr Val
   1               5                  10                  15    
 Leu Asp Leu Val Ser Asp Leu Glu Leu Leu Arg Asp Phe Pro Arg Gln
              20                  25                  30        
 Lys Ser Tyr Phe Ile Val Gly Thr Glu Gly Pro Ala Ala Ser Arg Gly
          35                  40                  45            
 Gly Pro Lys Val Val Phe Gly Asn Ser Trp Asp Ser Asp Glu Asp Met
      50                  55                  60                
 Ser Thr Arg Pro Gln Pro Gln Glu His Met Pro Lys Val Leu Asp Ser
  65                  70                  75                  80
 Asp Gly Tyr Ser Ser His Asn Gln Asp Gly Thr Asn Gly Glu Thr Glu
                  85                  90                  95    
 Ala Gln Arg Gly Thr Ala Thr His Gln Gly Gln Pro Thr Met Ala Ala
             100                 105                 110        
 Val Ser Glu Ser Asp Ser Leu Gly Glu Pro Ala Val Pro His Lys Gly
         115                 120                 125            
 Leu Asp Cys Tyr Leu Asp Ser Leu Phe Asp Pro Val Leu Ser Tyr Gly
     130                 135                 140                
 Asp Ala Asp Leu Glu Lys Pro Thr Ala Ile Ala Tyr Arg Met Lys Gly
 145                 150                 155                 160
 Gly Gly Gln Pro Gly Gly Gly Ser Ser Ser Gly Thr Glu Asp Thr Pro
                 165                 170                 175    
 Arg Arg Pro Pro Glu Pro Lys Pro Ile Pro Gly Leu Asp Ala Ser Thr
             180                 185                 190        
 Leu Ala Leu Gln Gln Ala Phe Ile His Lys Gln Ala Val Leu Leu Ala
         195                 200                 205            
 Arg Glu Met Thr Leu Gln Ala Thr Ala Leu Gln Gln Gln Pro Leu Ser
     210                 215                 220                
 Ala Ala Leu Arg Ser Leu Pro Ala Glu Lys Pro Pro Ala Pro Glu Ala
 225                 230                 235                 240
 Gln Pro Thr Ser Val Gly Thr Gly Pro Pro Ala Lys Pro Val Leu Leu
                 245                 250                 255    
 Arg Ala Thr Pro Lys Pro Leu Arg Pro Ala Pro Leu Ala Lys Ala Pro
             260                 265                 270        
 Arg Ile Pro Ile Lys Pro Val Ala Ala Pro Val Leu Ala Gln Asp Gln
         275                 280                 285            
 Ala Ser Pro Glu Thr Ser Leu His Arg Asp Ala Ala Thr Val Thr Gln
     290                 295                 300                
 Met His Phe Leu Thr Gly Gln Gly Arg Leu Leu Ser Leu Leu Asp Asp
 305                 310                 315                 320
 Ser Ser Leu His Leu Trp Glu Ile Val His His Asn Gly Cys Ala His
                 325                 330                 335    
 Leu Glu Glu Ala Leu Ser Phe Gln Leu Pro Ser Arg Pro Gly Phe Asp
             340                 345                 350        
 Gly Ala Ser Ala Pro Leu Ser Leu Thr Arg Val Thr Val Val Leu Leu
         355                 360                 365            
 Val Ala Ala Gly Asp Ile Ala Ala Leu Gly Thr Glu Gly Ser Ser Val
     370                 375                 380                
 Phe Phe Leu Asp Val Thr Thr Leu Thr Leu Leu Glu Gly Gln Thr Leu
 385                 390                 395                 400
 Ala Pro Gly Glu Val Leu Arg Ser Val Pro Asp Asp Tyr Arg Cys Gly
                 405                 410                 415    
 Lys Ala Leu Gly Pro Val Glu Ser Leu Gln Gly His Leu Arg Asp Pro
             420                 425                 430        
 Thr Lys Ile Leu Ile Gly Tyr Ser Arg Gly Leu Leu Val Ile Trp Asn
         435                 440                 445            
 Gln Ala Ser Gln Cys Val Asp His Ile Phe Leu Gly Asn Gln Gln Leu
     450                 455                 460                
 Glu Ser Leu Cys Trp Gly Arg Asp Ser Ser Thr Val Val Ser Ser His
 465                 470                 475                 480
 Ser Asp Gly Ser Tyr Ala Val Trp Ser Val Asp Ala Gly Ser Phe Pro
                 485                 490                 495    
 Thr Leu Gln Pro Thr Val Ala Thr Thr Pro Tyr Gly Arg Ala Cys Thr
             500                 505                 510        
 Pro Val Ala His Asp His Ile Asp Glu Leu Val Arg Gly Ala Val Phe
         515                 520                 525            
 Ser Glu Lys His Phe Cys Ile Glu Asp Leu
     530                 535            



      <210> 2655
      <211> 264
      <212> PRT
      <213> Homo sapiens


      <400> 2655
 Arg Ile Val Phe Glu Gln Asp His Ala Lys Leu Gly Thr Arg Ala Gly
   1               5                  10                  15    
 Thr Arg Arg Asp Ser Asp Met Ala Gly His Thr Gln Gln Pro Ser Gly
              20                  25                  30        
 Arg Gly Asn Pro Arg Pro Ala Pro Ser Pro Ser Pro Val Pro Gly Thr
          35                  40                  45            
 Val Pro Gly Ala Ser Glu Arg Val Ala Leu Lys Lys Glu Ile Gly Leu
      50                  55                  60                
 Leu Ser Ala Cys Thr Ile Ile Ile Gly Asn Ile Ile Gly Ser Gly Ile
  65                  70                  75                  80
 Phe Ile Ser Pro Lys Gly Val Leu Glu His Ser Gly Ser Val Gly Leu
                  85                  90                  95    
 Ala Leu Phe Val Trp Val Leu Gly Gly Gly Val Thr Ala Leu Gly Ser
             100                 105                 110        
 Leu Cys Tyr Ala Glu Leu Gly Val Ala Ile Pro Lys Ser Gly Gly Asp
         115                 120                 125            
 Tyr Ala Tyr Val Thr Glu Ile Phe Gly Gly Leu Ala Gly Phe Leu Leu
     130                 135                 140                
 Leu Trp Ser Ala Val Leu Ile Met Tyr Pro Thr Ser Leu Ala Val Ile
 145                 150                 155                 160
 Ser Met Thr Phe Ser Asn Tyr Val Leu Gln Pro Val Phe Pro Asn Cys
                 165                 170                 175    
 Ile Pro Pro Thr Thr Ala Ser Arg Val Leu Ser Met Ala Cys Leu Met
             180                 185                 190        
 Leu Leu Thr Trp Val Asn Ser Ser Ser Val Arg Trp Ala Thr Arg Ile
         195                 200                 205            
 Gln Asp Met Phe Thr Gly Gly Lys Leu Leu Ala Leu Ser Leu Ile Ile
     210                 215                 220                
 Gly Val Gly Leu Leu Gln Ile Phe Gln Gly His Phe Glu Glu Leu Arg
 225                 230                 235                 240
 Pro Ser Asn Ala Phe Ala Phe Trp Met Thr Pro Ser Val Gly His Leu
                 245                 250                 255    
 Ala Leu Ala Phe Leu Gln Gly Ser
             260                



      <210> 2656
      <211> 228
      <212> PRT
      <213> Homo sapiens


      <400> 2656
 Ser Met Asp Val Lys Glu Arg Arg Pro Tyr Cys Ser Leu Thr Lys Ser
   1               5                  10                  15    
 Arg Arg Glu Lys Glu Arg Arg Tyr Thr Asn Ser Ser Ala Asp Asn Glu
              20                  25                  30        
 Glu Cys Arg Val Pro Thr Gln Lys Ser Tyr Ser Ser Ser Glu Thr Leu
          35                  40                  45            
 Lys Ala Phe Asp His Asp Ser Ser Arg Leu Leu Tyr Gly Asn Arg Val
      50                  55                  60                
 Lys Asp Leu Val His Arg Glu Ala Asp Glu Phe Thr Arg Gln Gly Gln
  65                  70                  75                  80
 Asn Phe Thr Leu Arg Gln Leu Gly Val Cys Glu Pro Ala Thr Arg Arg
                  85                  90                  95    
 Gly Leu Ala Phe Cys Ala Glu Met Gly Leu Pro His Arg Gly Tyr Ser
             100                 105                 110        
 Ile Ser Ala Gly Ser Asp Ala Asp Thr Glu Asn Glu Ala Val Met Ser
         115                 120                 125            
 Pro Glu His Ala Met Arg Leu Trp Gly Arg Gly Val Lys Ser Gly Arg
     130                 135                 140                
 Ser Ser Cys Leu Ser Ser Arg Ser Asn Ser Ala Leu Thr Leu Thr Asp
 145                 150                 155                 160
 Thr Glu His Glu Asn Lys Ser Asp Ser Glu Asn Gly Lys Phe Ser Phe
                 165                 170                 175    
 Trp Leu Tyr Asn Val Gly Ile Gln Cys Phe Cys Leu Phe Trp Leu Thr
             180                 185                 190        
 Pro Arg Gly Gly Asp Val Phe Leu Ser Leu Phe Pro Leu Ile Leu Leu
         195                 200                 205            
 Ser Leu Ser Phe Leu Ser Ile Ser Phe Cys Phe Asn Val Val Glu Leu
     210                 215                 220                
 Lys Lys Cys Pro
 225            



      <210> 2657
      <211> 242
      <212> PRT
      <213> Homo sapiens


      <400> 2657
 Ser Pro Ser Gly Leu Gln Leu Pro Gln Tyr Ser Ala Ala Glu Leu Gln
   1               5                  10                  15    
 Ser Pro Ala Ala Pro Gly Leu Arg His Val Asp Ser Ala Gly Trp Gly
              20                  25                  30        
 Arg Arg Arg Ala Gly Pro Ala Gly Ser Ser Gly Tyr Arg Ala Gly Tyr
          35                  40                  45            
 Ser Ser Ser Thr Pro His Asp Ala Asn Met Ala Ala Gln Lys Asp Gln
      50                  55                  60                
 Gln Lys Asp Ala Glu Ala Glu Gly Leu Ser Gly Thr Thr Leu Leu Pro
  65                  70                  75                  80
 Lys Leu Ile Pro Ser Gly Ala Gly Arg Glu Trp Leu Glu Arg Arg Arg
                  85                  90                  95    
 Ala Thr Ile Arg Pro Trp Ser Thr Phe Val Asp Gln Gln Arg Phe Ser
             100                 105                 110        
 Arg Pro Arg Asn Leu Gly Glu Leu Cys Gln Arg Leu Val Arg Asn Val
         115                 120                 125            
 Glu Tyr Tyr Gln Ser Asn Tyr Val Phe Val Phe Leu Gly Leu Ile Leu
     130                 135                 140                
 Tyr Cys Val Val Thr Ser Pro Met Leu Leu Val Ala Leu Ala Val Phe
 145                 150                 155                 160
 Phe Gly Ala Cys Tyr Ile Leu Tyr Leu Arg Thr Leu Glu Ser Lys Leu
                 165                 170                 175    
 Val Leu Phe Gly Arg Glu Val Ser Pro Ala His Gln Tyr Ala Leu Ala
             180                 185                 190        
 Gly Gly Ile Ser Phe Pro Phe Phe Trp Leu Ala Gly Ala Gly Ser Ala
         195                 200                 205            
 Val Phe Trp Val Leu Gly Ala Thr Leu Val Val Ile Gly Ser His Ala
     210                 215                 220                
 Ala Phe His Gln Ile Glu Ala Val Asp Gly Glu Glu Leu Gln Met Glu
 225                 230                 235                 240
 Pro Val
        

      <210> 2658
      <211> 1486
      <212> PRT
      <213> Homo sapiens

      <220>
      <221> misc_feature
      <222> (1)...(1486)
      <223> Xaa = any amino acid or symbol as shown in the table 8 as set forth in Example 2


      <400> 2658
 Ala Thr Val Gly Ile Pro Gly Pro Arg Ala Gln Leu His Pro Thr Tyr
   1               5                  10                  15    
 Phe Asn Leu Ala Glu Ala Glu Asp Leu Ala Thr Ala Thr Cys Gly Glu
              20                  25                  30        
 Arg Gly Pro Gly Glu Gly Arg Pro Gln Pro Glu Leu Tyr Cys Lys Leu
          35                  40                  45            
 Val Gly Gly Pro Thr Ala Pro Gly Ser Gly His Thr Ile Gln Gly Gln
      50                  55                  60                
 Phe Cys Asp Tyr Cys Asn Ser Glu Asp Pro Arg Lys Ala His Pro Val
  65                  70                  75                  80
 Thr Asn Ala Ile Asp Gly Ser Glu Arg Trp Trp Gln Ser Pro Pro Leu
                  85                  90                  95    
 Ser Ser Gly Thr Gln Tyr Asn Arg Val Asn Leu Thr Leu Asp Leu Gly
             100                 105                 110        
 Gln Leu Phe His Val Ala Tyr Ile Leu Ile Lys Phe Ala Asn Ser Pro
         115                 120                 125            
 Arg Pro Asp Leu Trp Val Leu Glu Arg Ser Val Asp Phe Gly Ser Thr
     130                 135                 140                
 Tyr Ser Pro Trp Gln Tyr Phe Ala His Ser Lys Val Asp Cys Leu Lys
 145                 150                 155                 160
 Glu Phe Gly Arg Glu Ala Asn Met Ala Val Thr Arg Asp Asp Asp Val
                 165                 170                 175    
 Leu Cys Val Thr Glu Tyr Ser Arg Ile Val Pro Leu Glu Asn Gly Glu
             180                 185                 190        
 Val Val Val Ser Leu Ile Asn Gly Arg Pro Gly Ala Lys Asn Phe Thr
         195                 200                 205            
 Phe Ser His Thr Leu Arg Gly Val Tyr Gln Gly Asn Lys His Pro Leu
     210                 215                 220                
 Ala Phe Leu Arg Thr Asn Thr Leu Leu Gly His Leu Ile Ser Lys Ala
 225                 230                 235                 240
 Gln Arg Asp Gln Leu Ser Thr Arg Arg Tyr Tyr Tyr Ser Ile Lys Asp
                 245                 250                 255    
 Thr Ala Ile Gly Gly Gln Cys Val Cys Asn Gly His Ala Glu Val Cys
             260                 265                 270        
 Asn Ile Asn Asn Pro Glu Lys Leu Phe Arg Cys Glu Cys Gln His His
         275                 280                 285            
 Thr Cys Gly Glu Thr Cys Asp Arg Cys Cys Thr Gly Tyr Asn Gln Arg
     290                 295                 300                
 Arg Trp Arg Pro Ala Ala Trp Glu Gln Ser His Glu Cys Glu Ala Cys
 305                 310                 315                 320
 Asn Cys His Gly His Ala Ser Asn Cys Tyr Tyr Asp Pro Asp Val Glu
                 325                 330                 335    
 Arg Gln Gln Ala Ser Leu Asn Thr Gln Gly Ile Tyr Ala Gly Gly Gly
             340                 345                 350        
 Val Cys Ile Asn Cys Gln His Asn Thr Ala Gly Val Asn Cys Glu Gln
         355                 360                 365            
 Cys Ala Lys Gly Tyr Tyr Arg Pro Tyr Gly Val Pro Val Asp Ala Pro
     370                 375                 380                
 Asp Gly Cys Ile Pro Cys Ser Cys Asp Pro Glu His Ala Asp Gly Cys
 385                 390                 395                 400
 Glu Gln Gly Ser Gly Arg Cys His Cys Lys Pro Asn Phe His Gly Asp
                 405                 410                 415    
 Asn Cys Glu Lys Cys Ala Ile Gly Tyr Asn Phe Pro Phe Cys Leu Arg
             420                 425                 430        
 Ile Pro Ile Phe Pro Val Ser Thr Pro Ser Ser Glu Asp Pro Val Ala
         435                 440                 445            
 Gly Asp Ile Lys Gly Cys Asp Cys Asn Leu Glu Gly Val Leu Pro Glu
     450                 455                 460                
 Ile Cys Asp Ala His Gly Arg Cys Leu Cys Arg Pro Gly Val Glu Gly
 465                 470                 475                 480
 Pro Arg Cys Asp Thr Cys Arg Ser Gly Phe Tyr Ser Phe Pro Ile Cys
                 485                 490                 495    
 Gln Ala Cys Trp Cys Ser Ala Leu Gly Ser Tyr Gln Met Pro Cys Ser
             500                 505                 510        
 Ser Val Thr Gly Gln Cys Glu Cys Arg Pro Gly Val Thr Gly Gln Arg
         515                 520                 525            
 Cys Asp Arg Cys Leu Ser Gly Ala Tyr Asp Phe Pro His Cys Gln Gly
     530                 535                 540                
 Ser Ser Ser Ala Cys Asp Pro Ala Gly Thr Ile Asn Trp Asn Leu Gly
 545                 550                 555                 560
 Tyr Cys Gln Cys Lys Leu His Val Glu Gly Pro Thr Cys Ser Arg Cys
                 565                 570                 575    
 Lys Leu Leu Tyr Trp Asn Leu Asp Lys Glu Asn Pro Ser Gly Cys Ser
             580                 585                 590        
 Glu Cys Lys Cys His Lys Gly Gly Thr Val Ser Gly Thr Gly Glu Cys
         595                 600                 605            
 Arg Gln Gly Asp Gly Asp Cys His Cys Lys Ser His Val Gly Gly Asp
     610                 615                 620                
 Ser Cys Asp Thr Cys Glu Asp Gly Tyr Phe Ala Leu Glu Lys Ser Asn
 625                 630                 635                 640
 Tyr Phe Gly Cys Gln Gly Cys Gln Cys Asp Ile Gly Gly Ala Leu Ser
                 645                 650                 655    
 Ser Met Cys Ser Gly Pro Ser Gly Val Cys Gln Cys Arg Glu His Val
             660                 665                 670        
 Val Gly Lys Val Cys Gln Arg Pro Glu Asn Asn Tyr Tyr Phe Pro Asp
         675                 680                 685            
 Leu His His Met Lys Tyr Glu Ile Glu Asp Gly Ser Thr Pro Asn Gly
     690                 695                 700                
 Arg Asp Leu Arg Phe Gly Phe Asp Pro Leu Ala Phe Pro Glu Phe Ser
 705                 710                 715                 720
 Trp Arg Gly Tyr Ala Gln Met Ala Ser Val Gln Asn Asp Val Arg Ile
                 725                 730                 735    
 Thr Leu Asn Val Gly Lys Ser Ser Gly Ser Leu Phe Arg Val Ile Leu
             740                 745                 750        
 Arg Tyr Val Asn Pro Gly Thr Glu Ala Val Ser Gly His Ile Thr Ile
         755                 760                 765            
 Tyr Pro Ser Trp Gly Ala Ala Gln Ser Lys Glu Ile Ile Phe Leu Pro
     770                 775                 780                
 Ser Lys Glu Pro Ala Phe Val Thr Leu Pro Gly Asn Gly Phe Ala Asp
 785                 790                 795                 800
 Pro Phe Ser Ile Thr Pro Gly Met Trp Val Ala Cys Ile Lys Ala Glu
                 805                 810                 815    
 Gly Val Leu Leu Asp Tyr Leu Val Leu Leu Pro Arg Asp Tyr Tyr Glu
             820                 825                 830        
 Ala Ser Asp Leu Gln Leu Pro Val Thr Glu Pro Cys Ala Tyr Ala Gly
         835                 840                 845            
 Pro Pro Gln Glu Asn Cys Leu Leu Tyr Gln His Leu Pro Val Thr Arg
     850                 855                 860                
 Phe Pro Cys Thr Arg Ser Cys Glu Ala Arg His Phe Leu Leu Asp Gly
 865                 870                 875                 880
 Glu Pro Arg Pro Val Ala Val Arg Gln Pro Thr Pro Ala His Pro Val
                 885                 890                 895    
 Met Val Asp Leu Ser Gly Arg Glu Val Glu Leu His Leu Arg Val Arg
             900                 905                 910        
 Ile Pro Gln Val Gly Pro Tyr Val Val Val Val Glu Tyr Ser Thr Glu
         915                 920                 925            
 Ala Ala Gln Leu Phe Val Val Asp Ala Asn Val Lys Ser Ser Gly Ser
     930                 935                 940                
 Val Leu Ala Gly Gln Val Asn Ile Tyr Ser Cys Asn Tyr Ser Val Leu
 945                 950                 955                 960
 Cys Arg Ser Ala Val Ile Asp His Met Ser Arg Ile Ala Met Tyr Glu
                 965                 970                 975    
 Leu Leu Thr Asp Ala Asp Ile Gln Leu Lys Gly His Met Ala Arg Phe
             980                 985                 990        
 Leu Leu His Gln Val Cys Ile Ile Pro Ile Glu Glu Tyr Ser Ala Glu
         995                1000                1005            
 Tyr Val Arg Pro Gln Val His Cys Ile Ala Ser Tyr Gly Arg Phe Val
    1010                1015                1020                
 Asn Gln Ser Ala Thr Cys Val Ser Leu Ala His Glu Thr Pro Pro Thr
1025                1030                1035                1040
 Ala Leu Ile Leu Asp Val Leu Ser Gly Arg Pro Phe Pro His Leu Pro
                1045                1050                1055    
 Gln Gln Ser Ser Pro Ser Val Asp Val Leu Pro Gly Val Thr Leu Lys
            1060                1065                1070        
 Ala Pro Gln Asn Gln Val Thr Leu Arg Gly Arg Val Pro His Leu Gly
        1075                1080                1085            
 Arg Tyr Val Phe Val Ile His Phe Tyr Gln Ala Ala His Pro Thr Phe
    1090                1095                1100                
 Pro Ala Gln Val Ser Val Asp Gly Gly Trp Pro Arg Ala Gly Ser Phe
1105                1110                1115                1120
 His Ala Ser Phe Cys Pro His Val Leu Gly Cys Arg Asp Gln Val Ile
                1125                1130                1135    
 Val Xaa Gly Gln Ile Glu Phe Asp Ile Ser Glu Pro Glu Val Ala Ala
            1140                1145                1150        
 Thr Val Lys Val Pro Glu Gly Lys Ser Leu Val Leu Val Arg Val Leu
        1155                1160                1165            
 Val Val Pro Ala Glu Asn Tyr Asp Tyr Gln Ile Leu His Lys Lys Ser
    1170                1175                1180                
 Met Asp Lys Ser Leu Glu Phe Ile Thr Asn Cys Gly Lys Asn Ser Phe
1185                1190                1195                1200
 Tyr Leu Asp Pro Gln Thr Ala Ser Arg Phe Cys Lys Asn Ser Ala Arg
                1205                1210                1215    
 Ser Leu Val Ala Phe Tyr His Lys Gly Ala Leu Pro Cys Glu Cys His
            1220                1225                1230        
 Pro Thr Gly Ala Thr Gly Pro His Cys Ser Pro Glu Gly Gly Ser Ala
        1235                1240                1245            
 His Ala Ser Pro Thr Ser Ser Gly Gly Ser Ala Pro Ala Val Gln Gln
    1250                1255                1260                
 Ala Thr Tyr Gly Phe Pro Arg Cys Lys Pro Lys Pro Cys Ser Cys Gly
1265                1270                1275                1280
 Arg Arg Leu Cys Glu Glu Met Thr Gly Gln Cys Arg Cys Pro Pro Arg
                1285                1290                1295    
 Thr Val Arg Pro Gln Cys Glu Val Cys Glu Thr His Ser Phe Ser Leu
            1300                1305                1310        
 His Pro Met Ala Gly Cys Glu Gly Cys Asn Cys Ser Arg Arg Gly Thr
        1315                1320                1325            
 Ile Glu Ala Ala Met Pro Arg Cys Asp Arg Asp Ser Gly Gln Cys Gly
    1330                1335                1340                
 Cys Lys Pro Arg Ile Thr Gly Arg Gln Cys Asp Arg Cys Ala Ser Gly
1345                1350                1355                1360
 Phe Tyr Gly Phe Pro Glu Cys Val Pro Cys Asn Cys Asn Arg Asp Gly
                1365                1370                1375    
 Thr Glu Pro Gly Val Cys Asp Pro Gly Thr Gly Ala Cys Leu Cys Lys
            1380                1385                1390        
 Glu Asn Val Glu Gly Thr Glu Cys Asn Val Cys Arg Glu Gly Ser Phe
        1395                1400                1405            
 His Leu Asp Pro Ala Asn Leu Lys Gly Cys Thr Ser Cys Phe Cys Phe
    1410                1415                1420                
 Gly Val Asn Asn Gln Cys His Ser Ser His Lys Arg Arg Thr Lys Phe
1425                1430                1435                1440
 Val Asp Met Leu Gly Trp His Leu Glu Thr Ala Asp Arg Val Asp Ile
                1445                1450                1455    
 Pro Val Ser Phe Asn Pro Gly Ser Asn Ser Met Val Ala Asp Leu Gln
            1460                1465                1470        
 Glu Leu Pro Ala Thr Ile His Ser Ala Ser Trp Val Ala Pro
        1475                1480                1485    



      <210> 2659
      <211> 173
      <212> PRT
      <213> Homo sapiens


      <400> 2659
 Met Pro Ser Gly Cys Arg Cys Leu His Leu Val Cys Leu Leu Cys Ile
   1               5                  10                  15    
 Leu Gly Ala Pro Gly Gln Pro Val Arg Ala Asp Asp Cys Ser Ser His
              20                  25                  30        
 Cys Asp Leu Ala His Gly Cys Cys Ala Pro Asp Gly Ser Cys Arg Cys
          35                  40                  45            
 Asp Pro Gly Trp Glu Gly Leu His Cys Glu Arg Cys Val Arg Met Pro
      50                  55                  60                
 Gly Cys Gln His Gly Thr Cys His Gln Pro Trp Gln Cys Ile Cys His
  65                  70                  75                  80
 Ser Gly Trp Ala Gly Lys Phe Cys Asp Lys Asp Glu His Ile Cys Thr
                  85                  90                  95    
 Thr Gln Ser Pro Cys Gln Asn Gly Gly Gln Cys Met Tyr Asp Gly Gly
             100                 105                 110        
 Gly Glu Tyr His Cys Val Cys Leu Pro Gly Phe His Gly Arg Asp Cys
         115                 120                 125            
 Glu Arg Lys Ala Gly Pro Cys Glu Gln Ala Gly Ser Pro Cys Arg Asn
     130                 135                 140                
 Gly Gly Gln Cys Gln Asp Asp Gln Gly Phe Ala Leu Asn Phe Thr Cys
 145                 150                 155                 160
 Arg Cys Leu Val Gly Phe Val Gly Ala Arg Cys Asp Val
                 165                 170            



      <210> 2660
      <211> 182
      <212> PRT
      <213> Homo sapiens


      <400> 2660
 Asn Val Phe Ile Glu Pro Arg Ile Gln Gly Phe Met Lys Thr Ser Ala
   1               5                  10                  15    
 His Pro Gly Gln Lys His Pro Asp Phe Ser Met Gly Leu Leu Phe Pro
              20                  25                  30        
 Leu Leu Ala Ala Leu Glu Val Cys Ser Cys Gly Ser Ser Gly Ser Leu
          35                  40                  45            
 Gly Tyr Asn Leu Pro Gln Asn His Gly Leu Leu Gly Arg Asn Thr Leu
      50                  55                  60                
 Val Leu Leu Gly Gln Met Arg Arg Ile Ser Pro Phe Leu Cys Leu Lys
  65                  70                  75                  80
 Asp Arg Ser Asp Phe Arg Phe Pro Gln Glu Lys Val Glu Val Ser Gln
                  85                  90                  95    
 Leu Gln Lys Ala Gln Ala Met Ser Phe Leu Tyr Asp Val Leu Gln Gln
             100                 105                 110        
 Val Phe Asn Phe Ser His Lys Ala Leu Leu Cys Cys Met Glu His Asp
         115                 120                 125            
 Leu Pro Gly Pro Thr Pro His Phe Thr Ser Ser Ala Ala Gly Thr Pro
     130                 135                 140                
 Gly Asp Leu Leu Gly Ala Gly Asp Gly Arg Arg Arg Ser Trp Gly Gln
 145                 150                 155                 160
 Trp Val Ile Glu Gly Ser Thr Leu Ala Leu Arg Arg Tyr Phe Gln Glu
                 165                 170                 175    
 Ser Ile Ser Thr Leu Glu
             180        



      <210> 2661
      <211> 180
      <212> PRT
      <213> Homo sapiens


      <400> 2661
 Ser Gly Ser Ser His Ala Ser Asp Gly Ser Gly Phe Gln Glu Leu Arg
   1               5                  10                  15    
 Ile Cys Ser Glu Asp Gln Thr Pro Leu Ile Ala Gly Met Cys Ser Leu
              20                  25                  30        
 Pro Met Ala Arg Tyr Tyr Ile Ile Lys Tyr Ala Asp Gln Lys Ala Leu
          35                  40                  45            
 Tyr Thr Arg Asp Gly Gln Leu Leu Val Gly Asp Pro Val Ala Asp Asn
      50                  55                  60                
 Cys Cys Ala Glu Lys Ile Cys Thr Leu Pro Asn Arg Gly Leu Asp Arg
  65                  70                  75                  80
 Thr Lys Val Pro Ile Phe Leu Gly Ile Gln Gly Gly Ser Arg Cys Leu
                  85                  90                  95    
 Ala Cys Val Glu Thr Glu Glu Gly Pro Ser Leu Gln Leu Glu Asp Val
             100                 105                 110        
 Asn Ile Glu Glu Leu Tyr Lys Gly Gly Glu Glu Ala Thr Arg Phe Thr
         115                 120                 125            
 Phe Phe Gln Ser Ser Ser Gly Ser Ala Phe Arg Leu Glu Ala Ala Ala
     130                 135                 140                
 Trp Pro Gly Trp Phe Leu Cys Gly Pro Ala Glu Pro Gln Gln Pro Val
 145                 150                 155                 160
 Gln Leu Thr Lys Glu Ser Glu Pro Ser Ala Arg Thr Lys Phe Tyr Phe
                 165                 170                 175    
 Glu Gln Ser Trp
             180



      <210> 2662
      <211> 224
      <212> PRT
      <213> Homo sapiens


      <400> 2662
 Met Ala Phe Pro Ala Pro Ala Ile Met Phe Ile Val Gln Ser Ala Gly
   1               5                  10                  15    
 Arg Lys Lys Val Arg Glu Lys Trp Ser Gln Ala Ala Pro Met Ala Glu
              20                  25                  30        
 Gly Gly Gly Gln Asn His His Glu Val Val Lys Phe Met Asp Val Tyr
          35                  40                  45            
 Gln Arg Ser Tyr Cys His Pro Ile Glu Thr Leu Val Asp Ile Phe Gln
      50                  55                  60                
 Glu Tyr Pro Asp Glu Ile Glu Tyr Ile Phe Lys Pro Ser Cys Val Pro
  65                  70                  75                  80
 Leu Met Arg Cys Gly Gly Cys Cys Asn Asp Glu Gly Leu Glu Cys Val
                  85                  90                  95    
 Pro Thr Glu Glu Ser Asn Ile Thr Met Gln Ile Met Arg Ile Lys Pro
             100                 105                 110        
 His Gln Gly Gln His Ile Gly Glu Met Ser Phe Leu Gln His Asn Lys
         115                 120                 125            
 Cys Glu Cys Arg Pro Lys Lys Asp Arg Ala Arg Gln Glu Lys Lys Ser
     130                 135                 140                
 Val Arg Gly Lys Gly Lys Gly Gln Lys Arg Lys Arg Lys Lys Ser Arg
 145                 150                 155                 160
 Tyr Lys Ser Trp Ser Val Tyr Val Asp Val Thr Ser Arg Gly Gly Glu
                 165                 170                 175    
 Pro Gly Arg Arg Lys Glu Pro Pro Ser Gly Phe Arg Glu Pro Asp Leu
             180                 185                 190        
 Ser Pro Gly Lys Thr Asp Thr Glu Arg Ser Ile Gln Lys Pro Arg Cys
         195                 200                 205            
 Arg His His Thr Ile Thr Ile Asp Arg Thr Val Leu Asn Pro Glu Thr
     210                 215                 220                





      <210> 2663
      <211> 226
      <212> PRT
      <213> Homo sapiens


      <400> 2663
 Leu Leu Leu Ala Cys Arg Ser Met Asp Cys Tyr Leu Ala Ile Val His
   1               5                  10                  15    
 Ala Thr Arg Thr Leu Thr Gln Gln Arg His Leu Val Lys Phe Ile Cys
              20                  25                  30        
 Leu Gly Leu Arg Asn Leu Phe Leu Leu Leu Ser Leu Arg Ile Leu Leu
          35                  40                  45            
 Phe Arg Arg Thr Phe Tyr Pro Ser Asn Val Ser Pro Val Cys Tyr Glu
      50                  55                  60                
 Asp Met Gly Asn Asn Thr Ala Asn Trp Trp Met Leu Leu Arg Ile Leu
  65                  70                  75                  80
 Pro Gln Ser Phe Gly Phe Ile Val Pro Leu Leu Ile Met Leu Phe Cys
                  85                  90                  95    
 Tyr Arg Phe Thr Leu His Thr Leu Phe Lys Ala His Met Gly Gln Lys
             100                 105                 110        
 His Trp Thr Met Trp Val Ile Phe Ala Asp Ala Leu Ile Phe Leu Leu
         115                 120                 125            
 Cys Trp Leu Ala Tyr Asn Leu Asp Leu Leu Ala Asp Thr Leu Met Gly
     130                 135                 140                
 Thr Gln Met Thr Asn Glu Thr Cys Glu Arg Arg Asn Asp Ile Asn Gln
 145                 150                 155                 160
 Ala Leu Asp Ala Thr Glu Ile Leu Gly Ile Leu His Ser Tyr Leu Asn
                 165                 170                 175    
 Pro Leu Ile Tyr Ala Phe Ile Gly Gln Lys Phe Cys His Gly Leu Leu
             180                 185                 190        
 Lys Ile Ile Ala Ile His Gly Leu Ile Ser Lys Asp Ser Leu Pro Lys
         195                 200                 205            
 Asp Ser Arg Pro Ser Phe Val Gly Ser Ser Ser Gly His Thr Ser Thr
     210                 215                 220                
 Thr Leu
 225    



      <210> 2664
      <211> 104
      <212> PRT
      <213> Homo sapiens


      <400> 2664
 Leu Ser Gly Ile Trp Ser Ser Leu Ala Gly Ile Trp His Glu Pro Leu
   1               5                  10                  15    
 Ser Trp Asp Ser Glu Ser Thr Met Pro Ser Ser Val Ser Trp Gly Ile
              20                  25                  30        
 Leu Leu Leu Ala Gly Leu Cys Cys Leu Val Pro Val Ser Leu Ala Glu
          35                  40                  45            
 Asp Pro Gln Gly Asp Ala Ala His Lys Thr Asp Thr Ser His Cys Ala
      50                  55                  60                
 Pro Ala Leu Ala Lys Phe Leu Tyr Phe Trp Thr Phe Asn Thr Ile Gly
  65                  70                  75                  80
 Phe His Pro Val His Cys Arg Pro Cys Phe Leu Arg Gln Ser Phe Ser
                  85                  90                  95    
 Leu Ser Pro Arg Leu Gly Val Gln
             100                



      <210> 2665
      <211> 110
      <212> PRT
      <213> Homo sapiens


      <400> 2665
 Glu Val Ser Thr Ser Lys Thr Ala Gly Cys Arg Gly Cys Ala Leu Val
   1               5                  10                  15    
 Ile Ser Met Leu Cys Ile Ile Phe Pro Gln Gly Leu Phe Thr Arg Ala
              20                  25                  30        
 Leu Leu Arg Thr Cys Ser Ala Leu Leu His Ala Asp Trp Pro Glu Ile
          35                  40                  45            
 Ser Phe Val Val Val Val Val Phe Phe Lys Thr Glu Ser Cys Ser Val
      50                  55                  60                
 Ala Gln Asp Gly Val Gln Trp Cys Asp Leu Arg Ser Leu Lys Pro Pro
  65                  70                  75                  80
 Pro Pro Gly Ser Ser Asp Ser Pro Ala Ser Ala Ser Pro Val Ala Lys
                  85                  90                  95    
 Ile Thr Gly Met His His His Ala Arg His Gly Leu Lys Ser
             100                 105                 110



      <210> 2666
      <211> 25
      <212> PRT
      <213> Homo sapiens


      <400> 2666
 Ala Ala Ser Thr Cys Ile Ala Gly Glu Arg Arg Tyr Gly Thr Cys Ile
   1               5                  10                  15    
 Tyr Gln Gly Arg Leu Trp Ala Phe Cys
              20                  25



      <210> 2667
      <211> 409
      <212> PRT
      <213> Homo sapiens


      <400> 2667
 Ser Ser Ser Leu Ser Arg Phe Arg Ala Arg Arg Gly Pro Asn Trp Arg
   1               5                  10                  15    
 Gly Cys Trp Gly Cys Ser Gly Thr Val Gly Ala Ala Pro Gln Ala Gln
              20                  25                  30        
 Val Phe Glu Asn Lys Val Asn Ser Glu Lys Val Lys Leu Ser Leu Arg
          35                  40                  45            
 Asn Phe Pro His Asn Asp Tyr Glu Asp Val Phe Glu Glu Pro Ser Glu
      50                  55                  60                
 Ser Gly Ser Asp Pro Ser Met Trp Thr Ala Arg Gly Pro Phe Arg Arg
  65                  70                  75                  80
 Asp Arg Trp Ser Ser Glu Asp Glu Glu Ala Ala Gly Pro Ser Gln Ala
                  85                  90                  95    
 Leu Ser Pro Leu Leu Ser Asp Thr Arg Lys Ile Val Ser Glu Gly Glu
             100                 105                 110        
 Leu Asp Gln Leu Ala Gln Ile Arg Pro Leu Ile Phe Asn Phe His Glu
         115                 120                 125            
 Gln Thr Ala Ile Lys Asp Cys Leu Lys Ile Leu Glu Glu Lys Thr Ala
     130                 135                 140                
 Ala Tyr Asp Ile Met Gln Glu Phe Met Ala Leu Glu Leu Lys Asn Leu
 145                 150                 155                 160
 Pro Gly Glu Phe Tyr Ser Gly Asn Gln Pro Ser Asn Arg Glu Lys Asn
                 165                 170                 175    
 Arg Tyr Arg Asp Ile Leu Pro Tyr Asp Ser Thr Arg Val Pro Leu Gly
             180                 185                 190        
 Lys Ser Lys Asp Tyr Ile Asn Ala Ser Tyr Ile Arg Ile Val Asn Cys
         195                 200                 205            
 Gly Glu Glu Tyr Phe Tyr Ile Ala Thr Gln Gly Pro Leu Leu Ser Thr
     210                 215                 220                
 Ile Asp Asp Phe Trp Gln Met Val Leu Glu Asn Asn Ser Asn Val Ile
 225                 230                 235                 240
 Ala Met Ile Thr Arg Glu Met Glu Gly Gly Ile Ile Lys Cys Tyr His
                 245                 250                 255    
 Tyr Trp Pro Ile Ser Leu Lys Lys Pro Leu Glu Leu Lys His Phe Arg
             260                 265                 270        
 Val Phe Leu Glu Asn Tyr Gln Ile Leu Gln Tyr Phe Ile Ile Arg Met
         275                 280                 285            
 Phe Gln Val Val Glu Lys Ser Thr Gly Thr Ser His Ser Val Lys Gln
     290                 295                 300                
 Leu Gln Phe Thr Lys Trp Pro Asp His Gly Thr Pro Ala Ser Ala Asp
 305                 310                 315                 320
 Ser Phe Ile Lys Tyr Ile Arg Tyr Ala Arg Lys Ser His Leu Thr Gly
                 325                 330                 335    
 Pro Met Val Val His Cys Ser Ala Gly Ile Gly Arg Thr Gly Val Phe
             340                 345                 350        
 Leu Cys Val Asp Val Val Phe Cys Ala Ile Val Lys Asp Cys Ser Phe
         355                 360                 365            
 Asn Ile Met Asp Ile Val Ala Gln Met Arg Glu Gln Arg Ser Gly Met
     370                 375                 380                
 Val Gln Thr Lys Glu Gln Tyr His Phe Cys Tyr Asp Ile Val Leu Glu
 385                 390                 395                 400
 Val Leu Arg Lys Leu Leu Thr Leu Asp
                 405                



      <210> 2668
      <211> 242
      <212> PRT
      <213> Homo sapiens


      <400> 2668
 His Glu Gly Lys Pro Thr Arg Gly Arg Gly Arg Gly Gly Ser Leu Ser
   1               5                  10                  15    
 Thr Arg Gly Arg Gly Ser Glu Val Pro Asp Ser Ala His Leu Ala Pro
              20                  25                  30        
 Thr Pro Leu Phe Ser Glu Ser Gly Cys Cys Gly Leu Arg Ser Arg Phe
          35                  40                  45            
 Leu Thr Asp Cys Lys Met Glu Glu Gly Gly Asn Leu Gly Gly Leu Ile
      50                  55                  60                
 Lys Met Val His Leu Leu Val Leu Ser Gly Ala Trp Gly Met Gln Met
  65                  70                  75                  80
 Trp Val Thr Phe Val Ser Gly Phe Leu Leu Phe Arg Ser Leu Pro Arg
                  85                  90                  95    
 His Thr Phe Gly Leu Val Gln Ser Lys Leu Phe Pro Phe Tyr Phe His
             100                 105                 110        
 Ile Ser Met Gly Cys Ala Phe Ile Asn Leu Cys Ile Leu Ala Ser Gln
         115                 120                 125            
 His Ala Trp Ala Gln Leu Thr Phe Trp Glu Ala Ser Gln Leu Tyr Leu
     130                 135                 140                
 Leu Phe Leu Ser Leu Thr Leu Ala Thr Val Asn Ala Arg Trp Leu Glu
 145                 150                 155                 160
 Pro Arg Thr Thr Ala Ala Met Trp Ala Leu Gln Thr Val Glu Lys Glu
                 165                 170                 175    
 Arg Gly Leu Gly Gly Glu Val Pro Gly Ser His Gln Gly Pro Asp Pro
             180                 185                 190        
 Tyr Arg Gln Leu Arg Glu Lys Asp Pro Lys Tyr Ser Ala Leu Arg Gln
         195                 200                 205            
 Asn Phe Phe Arg Tyr His Gly Leu Ser Ser Leu Cys Asn Leu Gly Cys
     210                 215                 220                
 Val Leu Ser Asn Gly Leu Cys Leu Ala Gly Leu Ala Leu Glu Ile Arg
 225                 230                 235                 240
 Ser Leu
        



      <210> 2669
      <211> 100
      <212> PRT
      <213> Homo sapiens


      <400> 2669
 Glu Asn Leu Phe Ser Thr Asn Thr Met Lys Leu Cys Val Thr Val Leu
   1               5                  10                  15    
 Ser Leu Leu Met Leu Val Ala Ala Phe Cys Ser Pro Ala Leu Ser Ala
              20                  25                  30        
 Pro Met Gly Ser Asp Pro Pro Thr Ala Cys Cys Phe Ser Tyr Thr Ala
          35                  40                  45            
 Arg Lys Leu Pro Arg Asn Phe Val Val Asp Tyr Tyr Glu Thr Ser Ser
      50                  55                  60                
 Leu Cys Ser Gln Pro Ala Val Val Phe Gln Thr Lys Arg Ser Lys Gln
  65                  70                  75                  80
 Val Cys Ala Asp Pro Ser Glu Thr Trp Val Gln Glu Tyr Val Tyr Asp
                  85                  90                  95    
 Leu Glu Leu Asn
             100



      <210> 2670
      <211> 100
      <212> PRT
      <213> Homo sapiens


      <400> 2670
 Glu Asn Leu Phe Ser Thr Asn Thr Met Lys Leu Cys Val Thr Val Leu
   1               5                  10                  15    
 Ser Leu Leu Met Leu Val Ala Ala Phe Cys Ser Pro Ala Leu Ser Ala
              20                  25                  30        
 Pro Met Gly Ser Asp Pro Pro Thr Ala Cys Cys Phe Ser Tyr Thr Ala
          35                  40                  45            
 Arg Lys Leu Pro Arg Asn Phe Val Val Asp Tyr Tyr Glu Thr Ser Ser
      50                  55                  60                
 Leu Cys Ser Gln Pro Ala Val Val Phe Gln Thr Lys Arg Ser Lys Gln
  65                  70                  75                  80
 Val Cys Ala Asp Pro Ser Glu Thr Trp Val Gln Glu Tyr Val Tyr Asp
                  85                  90                  95    
 Leu Glu Leu Asn
             100



      <210> 2671
      <211> 70
      <212> PRT
      <213> Homo sapiens


      <400> 2671
 Met Lys Ile Phe Phe His Ile Phe Phe His Lys Cys Leu Phe Thr Tyr
   1               5                  10                  15    
 Arg Leu Phe Ile Thr Leu Ala Leu Ile Leu Trp Tyr Ser Asp Ile Glu
              20                  25                  30        
 Glu Ser Thr Phe Pro Pro Leu Met Arg Tyr Cys Pro Asn Thr Val Leu
          35                  40                  45            
 His Lys Ser Phe Phe Gln Met Ser Ala Phe Ile Thr Tyr Gln Phe Ser
      50                  55                  60                
 Leu Tyr Leu Ser Leu Phe
  65                  70



      <210> 2672
      <211> 112
      <212> PRT
      <213> Homo sapiens


      <400> 2672
 Gly Gln Pro Ala Arg Val Trp Ser Leu Asp Thr Met Gly Thr Arg Leu
   1               5                  10                  15    
 Leu Pro Ala Leu Phe Leu Val Leu Leu Val Leu Gly Phe Glu Val Gln
              20                  25                  30        
 Gly Thr Gln Gln Pro Gln Gln Asp Glu Met Pro Ser Pro Thr Phe Leu
          35                  40                  45            
 Thr Gln Val Lys Glu Ser Leu Ser Ser Tyr Trp Glu Ser Ala Lys Thr
      50                  55                  60                
 Ala Ala Gln Asn Leu Tyr Glu Lys Thr Tyr Leu Pro Ala Val Asp Glu
  65                  70                  75                  80
 Lys Leu Arg Asp Leu Tyr Ser Lys Ser Thr Ala Ala Met Ser Thr Tyr
                  85                  90                  95    
 Thr Gly Ile Phe Thr Asp Gln Val Leu Ser Val Leu Lys Gly Glu Glu
             100                 105                 110        





      <210> 2673
      <211> 46
      <212> PRT
      <213> Homo sapiens


      <400> 2673
 Met Asn Phe Leu Val Leu Phe Leu Thr Ile Leu Gly Phe Thr Arg Gly
   1               5                  10                  15    
 Leu Arg Ala Ala Met Met Pro Arg Arg Arg Trp Leu Pro Pro Pro Pro
              20                  25                  30        
 Thr Arg Pro Pro Thr Arg Pro Arg Thr Arg Gly Ser Thr Arg
          35                  40                  45    



      <210> 2674
      <211> 183
      <212> PRT
      <213> Homo sapiens


      <400> 2674
 Met Asn Leu Lys Leu Thr Gly Leu Lys Glu Ser Ala Gly Tyr His Ala
   1               5                  10                  15    
 Ala Pro Glu Gly Asn Leu Leu Thr Thr Ser Thr Trp Glu Leu Cys Arg
              20                  25                  30        
 His Pro His Pro Ala Ile Phe Gln Cys Asn Trp Pro Glu Val Lys Thr
          35                  40                  45            
 Thr Ala Ser Asp Gly Glu Gln Thr Thr Arg Glu Pro Val Leu Lys Ala
      50                  55                  60                
 Met Phe Leu Ala Asp Thr His Leu Leu Gly Glu Phe Leu Gly His Trp
  65                  70                  75                  80
 Leu Asp Lys Leu Arg Arg Ala Lys Asn Ile Val Asn Gly Thr Ile Leu
                  85                  90                  95    
 Leu Val Leu Arg Arg Ser Asn Leu Pro Lys Glu Glu His Leu Arg Arg
             100                 105                 110        
 Asn Asp Ile Lys Asp Val Gln Ser Tyr His Gln Lys Asn Asn Glu Gly
         115                 120                 125            
 Gln Leu Glu Phe Gly Val Ile Tyr His Cys Thr Glu Glu Arg Leu Tyr
     130                 135                 140                
 Thr Gly Arg Arg Gly Arg Gly Ala Phe Cys Asn Gly Gln Arg Leu Arg
 145                 150                 155                 160
 Val Ser Gly Glu Thr Asp Gly Leu Arg Gly Ser Glu Arg Ser Tyr Gly
                 165                 170                 175    
 His Gly Pro Ser Leu Leu Leu
             180            



      <210> 2675
      <211> 742
      <212> PRT
      <213> Homo sapiens


      <400> 2675
 Met Asp Ser Leu Lys Gln Glu Thr Gln Gly Leu Gln Lys Glu Lys Glu
   1               5                  10                  15    
 Ser Arg Glu Lys Glu Leu Met Gly Phe Ser Lys Ser Val Asn Glu Ala
              20                  25                  30        
 Arg Ser Lys Met Asp Val Ala Gln Ser Glu Leu Asp Ile Tyr Leu Ser
          35                  40                  45            
 Arg His Asn Thr Ala Val Ser Gln Leu Thr Lys Ala Lys Glu Ala Leu
      50                  55                  60                
 Ile Ala Ala Ser Glu Thr Leu Lys Glu Arg Lys Ala Ala Ile Arg Asp
  65                  70                  75                  80
 Ile Glu Gly Lys Leu Pro Gln Thr Glu Gln Glu Leu Lys Glu Lys Glu
                  85                  90                  95    
 Lys Glu Leu Gln Lys Leu Thr Gln Glu Glu Thr Asn Phe Lys Ser Leu
             100                 105                 110        
 Asp Lys Met Ala Val Trp Ala Lys Lys Met Thr Glu Ile Gln Thr Pro
         115                 120                 125            
 Glu Asn Thr Pro Arg Leu Phe Asp Leu Val Lys Val Lys Asp Glu Lys
     130                 135                 140                
 Ile Arg Gln Ala Phe Tyr Phe Ala Leu Arg Asp Thr Leu Val Ala Asp
 145                 150                 155                 160
 Asn Leu Asp Gln Ala Thr Arg Val Ala Tyr Gln Lys Asp Arg Arg Trp
                 165                 170                 175    
 Arg Val Val Thr Leu Gln Gly Gln Ile Ile Glu Gln Ser Gly Thr Met
             180                 185                 190        
 Thr Gly Gly Gly Ser Lys Val Met Lys Gly Arg Met Gly Ser Ser Leu
         195                 200                 205            
 Val Ile Glu Ile Ser Glu Glu Glu Val Asn Lys Met Glu Ser Gln Leu
     210                 215                 220                
 Gln Asn Asp Ser Lys Lys Ala Met Gln Ile Gln Glu Gln Lys Val Gln
 225                 230                 235                 240
 Leu Glu Glu Arg Val Val Lys Leu Arg His Ser Glu Arg Glu Met Arg
                 245                 250                 255    
 Asn Thr Leu Glu Lys Phe Thr Ala Ser Ile Gln Arg Leu Ile Glu Gln
             260                 265                 270        
 Glu Glu Tyr Leu Asn Val Gln Val Lys Glu Leu Glu Ala Asn Val Leu
         275                 280                 285            
 Ala Thr Ala Pro Asp Lys Lys Lys Gln Lys Leu Leu Glu Glu Asn Val
     290                 295                 300                
 Ser Ala Phe Lys Thr Glu Tyr Asp Ala Val Ala Glu Lys Ala Glu Glu
 305                 310                 315                 320
 Ser Leu Pro Glu Ile Gln Lys Glu His Arg Asn Leu Leu Gln Glu Leu
                 325                 330                 335    
 Lys Val Ile Gln Glu Asn Glu His Ala Leu Gln Lys Asp Ala Leu Ser
             340                 345                 350        
 Ile Lys Leu Lys Leu Glu Gln Ile Asp Gly His Ile Ala Glu His Asn
         355                 360                 365            
 Ser Lys Ile Lys Tyr Trp His Lys Glu Ile Ser Lys Ile Ser Leu His
     370                 375                 380                
 Pro Ile Glu Asp Asn Pro Ile Glu Glu Ile Ser Val Leu Ser Pro Glu
 385                 390                 395                 400
 Asp Leu Glu Ala Ile Lys Asn Pro Asp Ser Ile Thr Asn Gln Ile Ala
                 405                 410                 415    
 Leu Leu Glu Ala Arg Cys His Glu Met Lys Pro Asn Leu Gly Ala Ile
             420                 425                 430        
 Ala Glu Tyr Lys Lys Lys Glu Glu Leu Tyr Leu Gln Arg Val Ala Glu
         435                 440                 445            
 Leu Asp Lys Ile Thr Tyr Glu Arg Asp Ser Phe Arg Gln Ala Tyr Glu
     450                 455                 460                
 Asp Leu Arg Lys Gln Arg Leu Asn Glu Phe Met Gly Ser Val Arg Pro
 465                 470                 475                 480
 Pro Lys Lys Ser Trp Lys Lys Ile Phe Asn Leu Ser Gly Gly Glu Lys
                 485                 490                 495    
 Thr Leu Ser Ser Leu Ala Leu Val Phe Ala Leu His His Tyr Lys Pro
             500                 505                 510        
 Thr Pro Leu Tyr Phe Met Asp Glu Ile Asp Ala Ala Leu Asp Phe Lys
         515                 520                 525            
 Asn Val Ser Ile Val Ala Phe Tyr Ile Tyr Glu Ala Val Trp Phe Leu
     530                 535                 540                
 Ser Asn Ile Thr Ala Gly Asn Gln Gln Gln Val Gln Ala Val Ile Asp
 545                 550                 555                 560
 Ala Asn Leu Val Pro Met Ile Ile His Leu Leu Asp Lys Gly Asp Phe
                 565                 570                 575    
 Gly Thr Gln Lys Glu Ala Ala Trp Ala Ile Ser Asn Leu Thr Ile Ser
             580                 585                 590        
 Gly Arg Lys Asp Gln Val Ala Tyr Leu Ile Gln Gln Asn Val Ile Pro
         595                 600                 605            
 Pro Phe Cys Asn Leu Leu Thr Val Lys Asp Ala Gln Val Val Gln Val
     610                 615                 620                
 Val Leu Asp Gly Leu Ser Asn Ile Leu Lys Met Ala Glu Asp Glu Ala
 625                 630                 635                 640
 Glu Thr Ile Gly Asn Leu Ile Glu Glu Cys Gly Gly Leu Glu Lys Ile
                 645                 650                 655    
 Glu Gln Leu Gln Asn His Glu Asn Glu Asp Ile Tyr Lys Leu Ala Tyr
             660                 665                 670        
 Glu Ile Ile Asp Gln Phe Phe Ser Ser Asp Asp Val Phe Asn Asn Phe
         675                 680                 685            
 Val Val Phe Leu Ile Leu Tyr Ile Asn Ile Asp Leu Asp Lys Val Ile
     690                 695                 700                
 Tyr Ile Gly Ser Ser Leu Met Lys Gln Thr Pro Ser Pro Gly Val Thr
 705                 710                 715                 720
 Val Tyr Glu Ser Val Val Val Val Leu Tyr Val Asn Ala Cys Lys Leu
                 725                 730                 735    
 Asp Ser Pro Ser Gly Gly
             740        



      <210> 2676
      <211> 120
      <212> PRT
      <213> Homo sapiens

      <220>
      <221> misc_feature
      <222> (1)...(120)
      <223> Xaa = any amino acid or symbol as shown in the table 8 as set forth in Example 2


      <400> 2676
 Leu Thr Trp Pro Gln Pro His Ile Pro Ser Cys Pro Ala Met Ser Glu
   1               5                  10                  15    
 Glu Thr Leu Gln Ser Lys Leu Ala Ala Ala Lys Lys Lys Leu Pro Trp
              20                  25                  30        
 Gly Ala Val Gln Gly Ser Arg Ala Met Ser Asp Leu Leu Leu Leu Leu
          35                  40                  45            
 Leu Asp Leu Thr Leu Leu Leu Leu Leu Met Leu Leu Gly Phe Ala Gly
      50                  55                  60                
 Tyr Ser Gly Gln Leu Ala Gly Val Ala Val Ser Ala Gly Ser Pro Pro
  65                  70                  75                  80
 Ile Arg Tyr Lys Phe His Val Glu Pro Tyr Gly Glu Thr Gly Trp Leu
                  85                  90                  95    
 Leu Thr Glu Ser Cys Ser Ile Ser Pro Lys Leu Cys Ser Ile Ala Val
             100                 105                 110        
 His Xaa Asp Asn Pro Ala Trp Phe
         115                 120



      <210> 2677
      <211> 387
      <212> PRT
      <213> Homo sapiens


      <400> 2677
 Leu Leu Pro Ile Arg Leu Ala Trp His Glu Ala Ala Ser Glu Leu Arg
   1               5                  10                  15    
 Ala Leu Ser Gly Leu Glu Val Asp Pro Gly Glu Gly Trp Gly Arg Val
              20                  25                  30        
 Val Leu Ile Ser Pro Arg Thr Val Arg Phe Arg Val Leu Ser Pro Gly
          35                  40                  45            
 Val Arg Glu Glu Gly His Val Gln Asn Asn Gly Gln Asn Gln Ala Arg
      50                  55                  60                
 Pro Ala Arg Gly Val Thr Gly Ala Gly Gly Trp Gly Ser Ala Ala Val
  65                  70                  75                  80
 Cys Arg Gly Arg Ala Leu Arg Gly Arg Glu Pro Ala Leu Pro Ser Ala
                  85                  90                  95    
 Ser Phe Pro Asp Val Ala Ala Cys Pro Gly Ser Leu Asp Cys Ala Leu
             100                 105                 110        
 Lys Arg Arg Ala Arg Cys Pro Pro Gly Ala His Ala Cys Gly Pro Cys
         115                 120                 125            
 Leu Gln Pro Phe Gln Glu Asp Gln Gln Gly Leu Cys Val Pro Arg Met
     130                 135                 140                
 Arg Arg Pro Pro Gly Gly Gly Arg Pro Gln Pro Arg Leu Glu Asp Glu
 145                 150                 155                 160
 Ile Asp Phe Leu Ala Gln Glu Leu Ala Arg Lys Glu Ser Gly His Ser
                 165                 170                 175    
 Thr Pro Pro Leu Pro Lys Asp Arg Gln Arg Leu Pro Glu Pro Ala Thr
             180                 185                 190        
 Leu Gly Phe Ser Ala Arg Gly Gln Gly Leu Glu Leu Gly Leu Pro Ser
         195                 200                 205            
 Thr Pro Gly Thr Pro Thr Pro Thr Pro His Thr Ser Leu Gly Ser Pro
     210                 215                 220                
 Val Ser Ser Asp Pro Val His Met Ser Pro Leu Glu Pro Arg Gly Gly
 225                 230                 235                 240
 Gln Gly Asp Gly Leu Ala Leu Val Leu Ile Leu Ala Phe Cys Val Ala
                 245                 250                 255    
 Gly Ala Ala Ala Leu Ser Val Ala Ser Leu Cys Trp Cys Arg Leu Gln
             260                 265                 270        
 Arg Glu Ile Arg Leu Thr Gln Lys Ala Asp Tyr Ala Thr Ala Lys Ala
         275                 280                 285            
 Pro Gly Ser Pro Ala Ala Pro Arg Ile Ser Pro Gly Asp Gln Arg Leu
     290                 295                 300                
 Ala Gln Ser Ala Glu Met Tyr His Tyr Gln His Gln Arg Gln Gln Met
 305                 310                 315                 320
 Leu Cys Leu Glu Arg His Lys Glu Pro Pro Lys Glu Leu Asp Thr Ala
                 325                 330                 335    
 Ser Ser Asp Glu Glu Asn Glu Asp Gly Asp Phe Thr Val Tyr Glu Cys
             340                 345                 350        
 Pro Gly Leu Ala Pro Thr Gly Glu Met Glu Val Arg Asn Pro Leu Phe
         355                 360                 365            
 Asp His Ala Ala Leu Ser Ala Pro Leu Pro Ala Pro Ser Ser Pro Pro
     370                 375                 380                
 Ala Leu Pro
 385        



      <210> 2678
      <211> 71
      <212> PRT
      <213> Homo sapiens


      <400> 2678
 Met Arg Ser Met Pro Gly Asn Cys Leu Pro Leu Trp Pro His Leu Leu
   1               5                  10                  15    
 Ala Arg Pro Pro Arg Glu Leu Trp Pro Asp Val Met Gly Leu Pro Met
              20                  25                  30        
 Val Ala Ser Val Leu Cys Phe Ser Gly Phe Trp Ala Phe Ala His Ala
          35                  40                  45            
 Ile Leu Pro Ala Arg Ser Ala Leu Leu Ser Ser Pro Pro Thr Ser Val
      50                  55                  60                
 Pro Leu Thr Ser Leu Leu Arg
  65                  70    



      <210> 2679
      <211> 180
      <212> PRT
      <213> Homo sapiens


      <400> 2679
 Val His Val Cys Ser Ser Lys Met Gly Ala Leu Ser Thr Glu Arg Leu
   1               5                  10                  15    
 Gln Tyr Tyr Thr Gln Glu Leu Gly Val Arg Glu Arg Ser Gly His Ser
              20                  25                  30        
 Val Ser Leu Ile Asp Leu Trp Gly Leu Leu Val Glu Tyr Leu Leu Tyr
          35                  40                  45            
 Gln Glu Glu Asn Pro Ala Lys Leu Ser Asp Gln Gln Glu Ala Val Arg
      50                  55                  60                
 Gln Gly Gln Asn Pro Tyr Pro Ile Tyr Thr Ser Val Asn Val Arg Thr
  65                  70                  75                  80
 Asn Leu Ser Gly Glu Asp Phe Ala Glu Trp Cys Glu Phe Thr Pro Tyr
                  85                  90                  95    
 Glu Val Gly Phe Pro Lys Tyr Gly Ala Tyr Val Pro Thr Glu Leu Phe
             100                 105                 110        
 Gly Ser Glu Leu Phe Met Gly Arg Leu Leu Gln Leu Gln Pro Glu Pro
         115                 120                 125            
 Arg Ile Cys Tyr Leu Gln Gly Met Trp Gly Ser Ala Phe Ala Thr Ser
     130                 135                 140                
 Leu Asp Glu Ile Phe Leu Lys Thr Ala Gly Ser Gly Leu Ser Phe Leu
 145                 150                 155                 160
 Glu Trp Tyr Arg Gly Ser Val Asn Ile Thr Asp Asp Cys Gln Lys Pro
                 165                 170                 175    
 Gln Leu His Asn
             180



      <210> 2680
      <211> 119
      <212> PRT
      <213> Homo sapiens

      <220>
      <221> misc_feature
      <222> (1)...(119)
      <223> Xaa = any amino acid or symbol as shown in the table 8 as set forth in Example 2


      <400> 2680
 Glu Ala Gly Cys Pro Pro His Arg Ala Val Glu Leu Thr Pro Gly Cys
   1               5                  10                  15    
 Val Thr Arg Ser Leu Gly Gly Leu Ser Ile Cys Ser Phe Gln Gln Leu
              20                  25                  30        
 Pro Lys Asp Pro Thr Glu Gln Pro Gly Glu Ala Arg Glu Ser Glu Glu
          35                  40                  45            
 Xaa Val Thr Ser Leu Leu His Ser Ser Ala Ala Ala Ser Ala Pro Ser
      50                  55                  60                
 Thr Ala Thr Pro Val Pro Ala Ala Ala Ser Ala Pro Ser Thr Ala Thr
  65                  70                  75                  80
 Pro Val Pro Ala Ala Ala Ser Ala Pro Ser Thr Ser Thr Pro Gly Ser
                  85                  90                  95    
 Cys Ser Gln Pro Pro Pro His Leu Pro Pro Cys Leu Val Pro Ala Ala
             100                 105                 110        
 Ala Ser Ala Pro Pro Arg Ala
         115                



      <210> 2681
      <211> 366
      <212> PRT
      <213> Homo sapiens


      <400> 2681
 Thr Glu Pro Val Gly Tyr Thr Lys Ala Glu Glu Pro Ile Ala Met Arg
   1               5                  10                  15    
 Ser Leu Gly Ala Leu Leu Leu Leu Leu Ser Ala Cys Leu Ala Val Ser
              20                  25                  30        
 Ala Gly Pro Val Pro Thr Pro Pro Asp Asn Ile Gln Val Gln Glu Asn
          35                  40                  45            
 Phe Asn Ile Ser Arg Ile Tyr Gly Lys Trp Tyr Asn Leu Ala Ile Gly
      50                  55                  60                
 Ser Thr Cys Pro Trp Leu Lys Lys Ile Met Asp Arg Met Thr Val Ser
  65                  70                  75                  80
 Thr Leu Val Leu Gly Glu Gly Ala Thr Glu Ala Glu Ile Ser Met Thr
                  85                  90                  95    
 Ser Thr Arg Trp Arg Lys Gly Val Cys Glu Glu Thr Ser Gly Ala Tyr
             100                 105                 110        
 Glu Lys Thr Asp Thr Asp Gly Lys Phe Leu Tyr His Lys Ser Lys Trp
         115                 120                 125            
 Asn Ile Thr Met Glu Ser Tyr Val Val His Thr Asn Tyr Asp Glu Tyr
     130                 135                 140                
 Ala Ile Phe Leu Thr Lys Lys Phe Ser Arg His His Gly Pro Thr Ile
 145                 150                 155                 160
 Thr Ala Lys Leu Tyr Gly Arg Ala Pro Gln Leu Arg Glu Thr Leu Leu
                 165                 170                 175    
 Gln Asp Phe Arg Val Val Ala Gln Gly Val Gly Ile Pro Glu Asp Ser
             180                 185                 190        
 Ile Phe Thr Met Ala Asp Arg Gly Glu Cys Val Pro Gly Glu Gln Glu
         195                 200                 205            
 Pro Glu Pro Ile Leu Ile Pro Arg Val Arg Arg Ala Val Leu Pro Gln
     210                 215                 220                
 Glu Glu Glu Gly Ser Gly Gly Gly Gln Leu Val Thr Glu Val Thr Lys
 225                 230                 235                 240
 Lys Glu Asp Ser Cys Gln Leu Gly Tyr Ser Ala Gly Pro Cys Met Gly
                 245                 250                 255    
 Met Thr Ser Arg Tyr Phe Tyr Asn Gly Thr Ser Met Ala Cys Glu Thr
             260                 265                 270        
 Phe Gln Tyr Gly Gly Cys Met Gly Asn Gly Asn Asn Phe Val Thr Glu
         275                 280                 285            
 Lys Glu Cys Leu Gln Thr Cys Arg Thr Val Ala Ala Cys Asn Leu Pro
     290                 295                 300                
 Ile Val Arg Gly Pro Cys Arg Ala Phe Ile Gln Leu Trp Ala Phe Asp
 305                 310                 315                 320
 Ala Val Lys Gly Lys Cys Val Leu Phe Pro Tyr Gly Gly Cys Gln Gly
                 325                 330                 335    
 Asn Gly Asn Lys Phe Tyr Ser Glu Lys Glu Cys Arg Glu Tyr Cys Gly
             340                 345                 350        
 Val Pro Gly Asp Gly Asp Glu Glu Leu Leu Arg Phe Ser Asn
         355                 360                 365    



      <210> 2682
      <211> 275
      <212> PRT
      <213> Homo sapiens


      <400> 2682
 Met Ala Cys Pro Gly Phe Leu Trp Ala Leu Val Ile Ser Thr Cys Leu
   1               5                  10                  15    
 Glu Phe Ser Met Ala Gln Thr Val Thr Gln Ser Gln Pro Glu Met Ser
              20                  25                  30        
 Val Gln Glu Ala Glu Thr Val Thr Leu Ser Cys Thr Tyr Asp Thr Ser
          35                  40                  45            
 Glu Ser Asp Tyr Tyr Leu Phe Trp Tyr Lys Gln Pro Pro Ser Arg Gln
      50                  55                  60                
 Met Ile Leu Val Ile Arg Gln Glu Ala Tyr Lys Gln Gln Asn Ala Thr
  65                  70                  75                  80
 Glu Asn Arg Phe Ser Val Asn Phe Gln Lys Ala Ala Lys Ser Phe Ser
                  85                  90                  95    
 Leu Lys Ile Ser Asp Ser Gln Leu Gly Asp Ala Ala Met Tyr Phe Cys
             100                 105                 110        
 Ala Tyr Arg Ser Gly Arg Asp Asp Lys Ile Ile Phe Gly Lys Gly Thr
         115                 120                 125            
 Arg Leu His Ile Leu Pro Asn Ile Gln Asn Pro Asp Pro Ala Val Tyr
     130                 135                 140                
 Gln Leu Arg Asp Ser Lys Ser Ser Asp Lys Ser Val Cys Leu Phe Thr
 145                 150                 155                 160
 Asp Phe Asp Ser Gln Thr Asn Val Ser Gln Ser Lys Asp Ser Asp Val
                 165                 170                 175    
 Tyr Ile Thr Asp Lys Thr Val Leu Asp Met Arg Ser Met Asp Phe Lys
             180                 185                 190        
 Ser Asn Ser Ala Val Ala Trp Ser Asn Lys Ser Asp Phe Ala Cys Ala
         195                 200                 205            
 Asn Ala Phe Asn Asn Ser Ile Ile Pro Glu Asp Thr Phe Phe Pro Ser
     210                 215                 220                
 Pro Glu Ser Ser Cys Asp Val Lys Leu Val Glu Lys Ser Phe Glu Thr
 225                 230                 235                 240
 Asp Thr Asn Leu Asn Phe Gln Asn Leu Ser Val Ile Gly Phe Arg Ile
                 245                 250                 255    
 Leu Leu Leu Lys Val Ala Gly Phe Asn Leu Leu Met Thr Leu Arg Leu
             260                 265                 270        
 Trp Ser Ser
         275



      <210> 2683
      <211> 275
      <212> PRT
      <213> Homo sapiens


      <400> 2683
 Met Ala Cys Pro Gly Phe Leu Trp Ala Leu Val Ile Ser Thr Cys Leu
   1               5                  10                  15    
 Glu Phe Ser Met Ala Gln Thr Val Thr Gln Ser Gln Pro Glu Met Ser
              20                  25                  30        
 Val Gln Glu Ala Glu Thr Val Thr Leu Ser Cys Thr Tyr Asp Thr Ser
          35                  40                  45            
 Glu Ser Asp Tyr Tyr Leu Phe Trp Tyr Lys Gln Pro Pro Ser Arg Gln
      50                  55                  60                
 Met Ile Leu Val Ile Arg Gln Glu Ala Tyr Lys Gln Gln Asn Ala Thr
  65                  70                  75                  80
 Glu Asn Arg Phe Ser Val Asn Phe Gln Lys Ala Ala Lys Ser Phe Ser
                  85                  90                  95    
 Leu Lys Ile Ser Asp Ser Gln Leu Gly Asp Ala Ala Met Tyr Phe Cys
             100                 105                 110        
 Ala Tyr Arg Ser Gly Arg Asp Asp Lys Ile Ile Phe Gly Lys Gly Thr
         115                 120                 125            
 Arg Leu His Ile Leu Pro Asn Ile Gln Asn Pro Asp Pro Ala Val Tyr
     130                 135                 140                
 Gln Leu Arg Asp Ser Lys Ser Ser Asp Lys Ser Val Cys Leu Phe Thr
 145                 150                 155                 160
 Asp Phe Asp Ser Gln Thr Asn Val Ser Gln Ser Lys Asp Ser Asp Val
                 165                 170                 175    
 Tyr Ile Thr Asp Lys Thr Val Leu Asp Met Arg Ser Met Asp Phe Lys
             180                 185                 190        
 Ser Asn Ser Ala Val Ala Trp Ser Asn Lys Ser Asp Phe Ala Cys Ala
         195                 200                 205            
 Asn Ala Phe Asn Asn Ser Ile Ile Pro Glu Asp Thr Phe Phe Pro Ser
     210                 215                 220                
 Pro Glu Ser Ser Cys Asp Val Lys Leu Val Glu Lys Ser Phe Glu Thr
 225                 230                 235                 240
 Asp Thr Asn Leu Asn Phe Gln Asn Leu Ser Val Ile Gly Phe Arg Ile
                 245                 250                 255    
 Leu Leu Leu Lys Val Ala Gly Phe Asn Leu Leu Met Thr Leu Arg Leu
             260                 265                 270        
 Trp Ser Ser
         275



      <210> 2684
      <211> 68
      <212> PRT
      <213> Homo sapiens


      <400> 2684
 Met Ser Val Thr Phe Ile Ala Val Ala Arg Gly Lys Leu Phe Phe Glu
   1               5                  10                  15    
 Asn Leu Gly His Ser Glu Leu Pro Leu Ser Leu Glu Trp Gln Thr Ser
              20                  25                  30        
 Asp Gly Glu Val Glu Ala Arg Gly Ser Arg Gly Gly Glu Ala Leu Pro
          35                  40                  45            
 Arg Pro Gly Ser Met Gln Pro Cys Pro Ala Asp Val Thr Arg Arg Pro
      50                  55                  60                
 Pro Thr Arg Pro
  65            



      <210> 2685
      <211> 115
      <212> PRT
      <213> Homo sapiens


      <400> 2685
 Gly Thr Arg Gly Ala Val Pro Ser Thr Leu Glu Glu Val Val Leu Pro
   1               5                  10                  15    
 Pro Arg Ser Cys Arg Val Phe Trp Ile His Ser Gly Thr Thr Met Ser
              20                  25                  30        
 Lys Val Ser Phe Lys Ile Thr Leu Thr Ser Asp Pro Arg Leu Pro Tyr
          35                  40                  45            
 Lys Val Leu Ser Val Pro Glu Ser Thr Pro Phe Thr Ala Val Leu Lys
      50                  55                  60                
 Phe Ala Ala Glu Glu Phe Lys Val Pro Ala Ala Thr Ser Ala Ile Ile
  65                  70                  75                  80
 Thr Asn Asp Gly Ile Gly Ile Asn Pro Ala Gln Thr Ala Gly Asn Val
                  85                  90                  95    
 Phe Leu Lys His Gly Ser Glu Leu Arg Ile Ile Pro Arg Asp Arg Val
             100                 105                 110        
 Gly Ser Cys
         115



      <210> 2686
      <211> 149
      <212> PRT
      <213> Homo sapiens


      <400> 2686
 Gln Gln Leu Ile Cys Gln Pro Arg Pro Glu Pro Ser Arg Leu Arg Pro
   1               5                  10                  15    
 Ala Val Phe Ser Ile Thr Thr Val Met Ala Ser Ala Ser Val Thr Val
              20                  25                  30        
 Thr Val His Pro Pro Pro Val Leu Gly Pro Arg Arg Thr Pro Lys Arg
          35                  40                  45            
 Gly Ser Ala Gln Ala Arg Arg Ala Thr Gln Gly Leu Thr Thr Gly Cys
      50                  55                  60                
 Ser Pro Ile Thr Thr Val Met Ala Ser Ala Ser Val Thr Val Thr Val
  65                  70                  75                  80
 His Pro Pro Pro Val Pro Gly Pro Thr Gln Asp Pro Gln Ala Gly Leu
                  85                  90                  95    
 Cys Thr Gly Gln Glu Gly Tyr Pro Gly Thr Asp His Gly Leu Phe Met
             100                 105                 110        
 Gly Pro His Leu Leu Phe Gln Val Gln Gly Glu Arg Thr Asn Leu Lys
         115                 120                 125            
 Val Glu Val Thr Glu Leu Gln Asp Val Glu Cys Glu Glu Trp Pro Arg
     130                 135                 140                
 Gly Ser Ser Ser Asn
 145                



      <210> 2687
      <211> 298
      <212> PRT
      <213> Homo sapiens

      <220>
      <221> misc_feature
      <222> (1)...(298)
      <223> Xaa = any amino acid or symbol as shown in the table 8 as set forth in Example 2


      <400> 2687
 Leu Thr Ala Gly Ala Ser His Thr Gln Asp Ala Ser Gln Ser Thr Ser
   1               5                  10                  15    
 Ala Lys Tyr Pro Ala Ala Ala Gln Asn Leu Cys Val Thr Asn Ala Met
              20                  25                  30        
 Arg Glu Asp Leu Ala Asp Ile Trp Tyr Ile Arg Ala Val Thr Val Tyr
          35                  40                  45            
 Asp Lys Pro Ala Ser Phe Phe Lys Glu Thr Pro Leu Asp Leu Gln His
      50                  55                  60                
 Arg Leu Phe Met Lys Leu Gly Ser Met His Ser Pro Phe Arg Ala Arg
  65                  70                  75                  80
 Ser Glu Pro Glu Asp Pro Val Thr Glu Arg Ser Ala Phe Thr Glu Arg
                  85                  90                  95    
 Asp Ala Gly Ser Gly Leu Val Thr Arg Leu Arg Glu Arg Pro Ala Leu
             100                 105                 110        
 Leu Val Ser Ser Thr Ser Trp Thr Glu Asp Glu Asp Phe Ser Ile Leu
         115                 120                 125            
 Leu Ala Ala Leu Glu Ser Arg Val Xaa Thr Met Thr Leu Asp Gly His
     130                 135                 140                
 Asn Leu Pro Ser Leu Val Cys Val Ile Thr Gly Lys Gly Pro Leu Arg
 145                 150                 155                 160
 Glu Tyr Tyr Ser Arg Leu Ile His Gln Lys His Phe Gln His Ile Gln
                 165                 170                 175    
 Val Cys Thr Pro Trp Leu Glu Ala Glu Asp Tyr Pro Leu Leu Leu Gly
             180                 185                 190        
 Ser Ala Asp Leu Gly Val Cys Leu His Thr Ser Ser Ser Gly Leu Asp
         195                 200                 205            
 Leu Pro Met Lys Val Val Asp Met Phe Gly Cys Cys Leu Pro Val Cys
     210                 215                 220                
 Ala Val Asn Phe Lys Cys Leu His Glu Leu Val Lys His Glu Glu Asn
 225                 230                 235                 240
 Gly Leu Val Phe Glu Asp Ser Glu Glu Leu Ala Ala Gln Leu Gln Met
                 245                 250                 255    
 Leu Phe Ser Asn Phe Pro Asp Pro Ala Gly Lys Leu Asn Gln Phe Arg
             260                 265                 270        
 Lys Asn Leu Arg Glu Ser Gln Gln Leu Arg Trp Asp Glu Ser Trp Val
         275                 280                 285            
 Gln Thr Val Leu Pro Leu Val Met Asp Thr
     290                 295            



      <210> 2688
      <211> 87
      <212> PRT
      <213> Homo sapiens

      <220>
      <221> misc_feature
      <222> (1)...(87)
      <223> Xaa = any amino acid or symbol as shown in the table 8 as set forth in Example 2


      <400> 2688
 Asn Pro Arg Asp Gly Pro Thr Thr Ala Ala Cys Trp Ala Ala Ala Trp
   1               5                  10                  15    
 Ala Ser Ala Thr Thr Gly Pro Ser Cys Ala Cys Cys Phe Met Pro Pro
              20                  25                  30        
 Ala Ser Cys Ser Thr Ser Leu Cys Cys Trp Ala Leu His Cys Arg Pro
          35                  40                  45            
 Cys Cys Glu Pro Thr Arg Pro Ser Thr Trp Leu Pro Ser Ser Cys Phe
      50                  55                  60                
 Pro Gly Ser Cys Cys Ser Gln Pro Xaa Ser Pro Leu Ser Ser Cys Lys
  65                  70                  75                  80
 Pro Leu Lys Pro Pro Val Phe
                  85        



      <210> 2689
      <211> 128
      <212> PRT
      <213> Homo sapiens


      <400> 2689
 Met Ala Cys Arg Val Leu Gln Gly Leu Pro Phe Ala Cys Leu Ser Ser
   1               5                  10                  15    
 Pro Ile Cys Ser His Ser Ala Leu Thr Leu Asp His Ser Leu Leu Cys
              20                  25                  30        
 Leu Asn Phe Phe Phe Asn Pro Tyr Ala Leu Leu Pro Asn Phe Tyr Leu
          35                  40                  45            
 Phe Gly Lys Phe Gln Leu Arg Ile Pro Ser Ser Gly Lys Pro Phe Leu
      50                  55                  60                
 Thr Ser Glu Asp Gln Asp Pro Ala Gly Ile Phe Glu Leu Val Glu Val
  65                  70                  75                  80
 Val Gly Asn Gly Thr Tyr Gly Gln Val Tyr Lys Val Arg Arg Met Val
                  85                  90                  95    
 Trp Lys Tyr Asp Leu His Ile Cys Arg Ala Val Leu Gly Gly Val Glu
             100                 105                 110        
 Gly Ser Arg Phe Leu Val Cys Arg Ser Glu Gly Gly Tyr Gly Arg Cys
         115                 120                 125            





      <210> 2690
      <211> 182
      <212> PRT
      <213> Homo sapiens


      <400> 2690
 Met Ser Leu Lys Met Leu Ile Ser Arg Asn Lys Leu Ile Leu Leu Leu
   1               5                  10                  15    
 Gly Ile Val Phe Phe Glu Arg Gly Lys Ser Ala Thr Leu Ser Leu Pro
              20                  25                  30        
 Lys Ala Pro Ser Cys Gly Gln Ser Leu Val Lys Val Gln Pro Trp Asn
          35                  40                  45            
 Tyr Phe Asn Ile Phe Ser Arg Ile Leu Gly Gly Ser Gln Val Glu Lys
      50                  55                  60                
 Gly Ser Tyr Pro Trp Gln Val Ser Leu Lys Gln Arg Gln Lys His Ile
  65                  70                  75                  80
 Cys Gly Gly Ser Ile Val Ser Pro Gln Trp Val Ile Thr Ala Ala His
                  85                  90                  95    
 Cys Ile Ala Asn Arg Asn Ile Val Ser Thr Leu Asn Val Thr Ala Gly
             100                 105                 110        
 Glu Tyr Asp Leu Ser Gln Thr Asp Pro Gly Glu Gln Thr Leu Thr Ile
         115                 120                 125            
 Glu Thr Val Ile Ile His Pro His Phe Ser Thr Lys Lys Pro Met Asp
     130                 135                 140                
 Tyr Asp Ile Ala Leu Leu Lys Met Ala Gly Ala Phe Gln Phe Gly His
 145                 150                 155                 160
 Phe Val Gly Pro Ile Cys Leu Pro Glu Leu Arg Glu Gln Phe Glu Ala
                 165                 170                 175    
 Gly Phe Ile Cys Thr Thr
             180        



      <210> 2691
      <211> 99
      <212> PRT
      <213> Homo sapiens


      <400> 2691
 Arg Ile Gln Gly Cys Ser Cys Trp Val Lys Leu Cys Pro Lys Val Glu
   1               5                  10                  15    
 Lys Trp Val Gln Arg Thr Asp Ala Glu Gln Glu Ser Gln Thr Lys Ala
              20                  25                  30        
 Glu Ile Gln Asp Met Lys Gln Glu Leu Ser Ala Val Asn Met Met Asp
          35                  40                  45            
 Lys Phe Ala Arg Ser Ala Arg Leu Glu Arg Lys Ile Asn Lys Met Met
      50                  55                  60                
 Asn Lys Leu Lys Thr His Val Lys Val Gln Thr Ala Gln Ser Gly Met
  65                  70                  75                  80
 Leu Lys Trp Val Ile Ser Val Ala Phe Tyr Lys Leu Pro Gly Thr Val
                  85                  90                  95    
 Ile Arg Leu
            



      <210> 2692
      <211> 102
      <212> PRT
      <213> Homo sapiens


      <400> 2692
 Leu Val Gln Cys Gly Gly Ile Pro Ala Ser Gly Arg Gln Ala Leu Val
   1               5                  10                  15    
 Val Gly Lys Pro Ser Pro Tyr Met Phe Glu Cys Ile Thr Glu Asn Phe
              20                  25                  30        
 Ser Ile Asp Pro Ala Arg Thr Leu Met Val Gly Asp Arg Leu Glu Thr
          35                  40                  45            
 Asp Ile Leu Phe Gly His Arg Cys Gly Met Thr Thr Val Leu Thr Leu
      50                  55                  60                
 Thr Gly Val Ser Arg Leu Glu Glu Ala Gln Ala Tyr Leu Ala Ala Gly
  65                  70                  75                  80
 Gln His Asp Leu Val Pro His Tyr Tyr Val Glu Ser Ile Ala Asp Leu
                  85                  90                  95    
 Thr Glu Gly Leu Glu Asp
             100        



      <210> 2693
      <211> 76
      <212> PRT
      <213> Homo sapiens

      <220>
      <221> misc_feature
      <222> (1)...(76)
      <223> Xaa = any amino acid or symbol as shown in the table 8 as set forth in Example 2


      <400> 2693
 Trp Gly Asp Gln Pro Gly Gly Gly Asp Gly Val Gly Met Glu Asp Lys
   1               5                  10                  15    
 Gly Gly Ser Arg Gly Gln Ser Pro Gly Gly Ser Lys Gly Gly His Lys
              20                  25                  30        
 Gly Gly Ala Gly Gly Phe Arg Xaa Glu Ala Gly Gly Arg Lys Gly Thr
          35                  40                  45            
 Ser Ser Gly Ser Arg Gly Arg Gly Trp Gly Glu Gly Gly Xaa Glu Gly
      50                  55                  60                
 Ala Glu Asp Val Ala His Ser Gly Ser Gln Gln Pro
  65                  70                  75    



      <210> 2694
      <211> 26
      <212> PRT
      <213> Homo sapiens


      <400> 2694
 Leu Asn Ile Ser Thr Leu Cys Gln Leu Ala Ile Cys Arg Val Cys Val
   1               5                  10                  15    
 Cys Ala Cys Val Cys Val Cys Val Cys Val
              20                  25    



      <210> 2695
      <211> 94
      <212> PRT
      <213> Homo sapiens


      <400> 2695
 Thr Gly Thr Ala Trp Thr Pro Pro Pro Pro Pro Leu Thr Thr Gly Ala
   1               5                  10                  15    
 Pro Cys Thr Pro Pro Pro Arg Cys Thr Ala Arg Gly Arg Thr Pro Gly
              20                  25                  30        
 Asp Ser His Leu Gly Gly Gly Pro Ala Ala Thr Ala Gly Gly Pro Arg
          35                  40                  45            
 Thr Ser Pro Met Ser Ser Gly Gly Pro Ser Ala Pro Gly Met Arg Pro
      50                  55                  60                
 Pro Ala Ser Ser Pro Lys Arg Asn Thr Thr Ser Leu Leu Asn Ser Gly
  65                  70                  75                  80
 Leu Glu Pro Thr Phe Ser Phe Arg Ile Thr Phe Gly Phe Met
                  85                  90                



      <210> 2696
      <211> 146
      <212> PRT
      <213> Homo sapiens

      <220>
      <221> misc_feature
      <222> (1)...(146)
      <223> Xaa = any amino acid or symbol as shown in the table 8 as set forth in Example 2


      <400> 2696
 Ala Arg Ala Ser Gly Arg Pro Gly Pro Thr Ala Gly Ala Gln Pro Gly
   1               5                  10                  15    
 Ala Gln Pro Ala Pro Gly Arg Arg His Arg Ala Arg His Leu Ala Xaa
              20                  25                  30        
 Ala Pro Ser Pro Pro Asp Ala Gly Pro Gln Pro Gln Xaa Ala Val Leu
          35                  40                  45            
 Cys Ala Pro Gly Pro Ala Xaa Gly Pro Arg Gly Ala Ala Pro Arg Gly
      50                  55                  60                
 Gln Pro His Arg Pro Arg Gly Pro Arg Gly Leu Pro Gln His Thr Pro
  65                  70                  75                  80
 Pro Ala Cys Pro Leu Pro Gln Gly Ala Pro Arg Val Thr Gly Gly Val
                  85                  90                  95    
 Glu Val Gly Arg Gly Gly Pro Gly Arg Val Arg Pro Pro Pro Val Gln
             100                 105                 110        
 Gly Gln Gln Ala Ser His Asp Glu His Arg Gly Xaa Gly Leu Pro Gly
         115                 120                 125            
 Ala Pro Lys Pro Ala Cys Gly Gly His Gly Arg Glu Ser Gly Ala Gly
     130                 135                 140                
 Pro Asp
 145    



      <210> 2697
      <211> 165
      <212> PRT
      <213> Homo sapiens

      <220>
      <221> misc_feature
      <222> (1)...(165)
      <223> Xaa = any amino acid or symbol as shown in the table 8 as set forth in Example 2


      <400> 2697
 Tyr Lys Glu Val Val Thr Gln His Phe Leu Xaa Val Thr Tyr Glu Thr
   1               5                  10                  15    
 His Pro Ile Tyr Tyr Leu Lys Ile Ser Gln Pro Ser Gly Asn Pro Lys
              20                  25                  30        
 Lys Ile Ile Trp Met Asp Cys Gly Ile His Ala Arg Glu Trp Ile Ala
          35                  40                  45            
 Pro Ala Phe Cys Gln Trp Phe Val Lys Glu Ile Leu Gln Asn His Lys
      50                  55                  60                
 Asp Asn Ser Arg Ile Arg Lys Leu Leu Met Asn Leu Asp Phe Tyr Val
  65                  70                  75                  80
 Leu Pro Val Leu Asn Ile Asp Gly Tyr Ile Tyr Thr Trp Thr Thr Asp
                  85                  90                  95    
 Arg Leu Trp Arg Lys Ser Arg Ser Pro His Asn Asn Gly Thr Cys Phe
             100                 105                 110        
 Gly Thr Asp Leu Asn Arg Asn Phe Asn Ala Ser Trp Cys Ser Ile Gly
         115                 120                 125            
 Ala Ser Arg Asn Cys Gln Asp Gln Thr Phe Cys Gly Thr Gly Pro Val
     130                 135                 140                
 Ser Glu Pro Glu Thr Lys Ala Val Ala Ser Phe Ile Glu Ser Lys Asn
 145                 150                 155                 160
 Asp Asp Phe Cys Ala
                 165



      <210> 2698
      <211> 112
      <212> PRT
      <213> Homo sapiens


      <400> 2698
 Met Thr Ala Gly Val Leu Trp Gly Leu Phe Gly Val Leu Gly Phe Thr
   1               5                  10                  15    
 Gly Val Ala Leu Leu Leu Tyr Ala Leu Phe His Lys Ile Ser Gly Glu
              20                  25                  30        
 Ser Ser Ala Thr Asn Glu Pro Arg Gly Ala Ser Arg Pro Asn Pro Gln
          35                  40                  45            
 Glu Phe Thr Tyr Ser Ser Pro Thr Pro Asp Met Glu Glu Leu Gln Pro
      50                  55                  60                
 Val Tyr Val Asn Val Gly Ser Val Asp Val Asp Val Val Tyr Ser Gln
  65                  70                  75                  80
 Val Trp Ser Met Gln Gln Pro Glu Ser Ser Ala Asn Ile Arg Thr Leu
                  85                  90                  95    
 Leu Glu Asn Lys Asp Ser Gln Val Ile Tyr Ser Ser Val Lys Lys Ser
             100                 105                 110        





      <210> 2699
      <211> 218
      <212> PRT
      <213> Homo sapiens


      <400> 2699
 Ala Val Pro Ser Arg Cys Gly Arg Pro Gly Ala Arg Ala Arg Gly Ala
   1               5                  10                  15    
 Met Glu Ala Ala Leu Leu Gly Leu Cys Asn Trp Ser Thr Leu Gly Val
              20                  25                  30        
 Cys Ala Ala Leu Lys Leu Pro Gln Ile Ser Ala Val Leu Ala Ala Arg
          35                  40                  45            
 Ser Ala Arg Gly Leu Ser Leu Pro Ser Leu Leu Leu Glu Leu Ala Gly
      50                  55                  60                
 Phe Leu Val Phe Leu Arg Tyr Gln Cys Tyr Tyr Gly Tyr Pro Pro Leu
  65                  70                  75                  80
 Thr Tyr Leu Glu Tyr Pro Ile Leu Ile Ala Gln Asp Val Ile Leu Leu
                  85                  90                  95    
 Leu Cys Ile Phe His Phe Asn Gly Asn Val Lys Gln Ala Thr Pro Tyr
             100                 105                 110        
 Ile Ala Val Leu Val Ser Ser Trp Phe Ile Leu Ala Leu Gln Lys Trp
         115                 120                 125            
 Ile Ile Asp Leu Ala Met Asn Leu Cys Thr Phe Ile Ser Ala Ala Ser
     130                 135                 140                
 Lys Phe Ala Gln Leu Gln Cys Leu Trp Lys Thr Arg Asp Ser Gly Thr
 145                 150                 155                 160
 Val Ser Ala Leu Thr Trp Ser Leu Ser Ser Tyr Thr Cys Ala Thr Arg
                 165                 170                 175    
 Ile Ile Thr Thr Leu Met Thr Thr Asn Asp Phe Thr Ile Leu Leu Arg
             180                 185                 190        
 Phe Gly Ile Met Leu Ala Leu Asn Ile Trp Val Thr Val Thr Val Leu
         195                 200                 205            
 Arg Tyr Arg Lys Thr Ala Ile Lys Ala Glu
     210                 215            



      <210> 2700
      <211> 337
      <212> PRT
      <213> Homo sapiens

      <220>
      <221> misc_feature
      <222> (1)...(337)
      <223> Xaa = any amino acid or symbol as shown in the table 8 as set forth in Example 2


      <400> 2700
 Glu Phe Cys Ser Pro Thr Ser Pro Arg Pro Phe Phe Cys Pro Ile Ser
   1               5                  10                  15    
 Pro Glu Ser Val Ala Glu Ala Pro Val Phe Gly Ser Pro Ala Ile Thr
              20                  25                  30        
 Ala Pro Gln Met Gly Pro Gly Pro Met Pro Pro Asp Gly Leu Val Ala
          35                  40                  45            
 Ser Asp Pro Gly Ala Thr Ala Gly Ser Leu Pro Val Pro Ala Ala Ala
      50                  55                  60                
 Leu Asn Thr Gly Thr Gln Thr Thr Ser Ala Ala Ala Ala Ala Cys Asn
  65                  70                  75                  80
 Ala Ser Gly Arg Pro Pro Ala Arg Arg Pro Val Pro Ala Lys Gly His
                  85                  90                  95    
 Cys Pro Leu Thr Pro Gly Asn Pro Gly Ala Pro Ser Ser Gln Glu Arg
             100                 105                 110        
 Ser Ser Pro Ala Ser Ser Ile Ala Trp Arg Thr Pro Glu Pro Ala Pro
         115                 120                 125            
 Ser Ala Gly Leu Ala Glu Phe Pro Ser Ala Arg Gly Ala Gly Pro Ala
     130                 135                 140                
 Pro Asp Leu Gly Gly Asp Ser Asp Pro Pro Val Tyr Ser Ala Leu Ala
 145                 150                 155                 160
 Ser Leu Leu Ala Gln Gly Glu Ser Pro Thr Pro Ile Pro Ile Leu Ala
                 165                 170                 175    
 Trp Ser Ala Glu Ser Pro Thr Pro Thr Pro Leu Pro Pro Arg Ile Cys
             180                 185                 190        
 Pro Pro Gln Ala Pro Trp Arg Gln Gly Thr His Gly Arg Arg Pro Pro
         195                 200                 205            
 Thr Ser Thr Pro Glu Gln Gly Thr Val Gln Ser Gly Val Thr Thr Pro
     210                 215                 220                
 Val Ser Pro Pro Gly Xaa Ala Gly Gly Ala Gly Arg Ala Asp Cys Thr
 225                 230                 235                 240
 Ala Gly Pro Xaa Ala Trp Ala Arg Trp Gly Tyr Gly Pro Trp His Tyr
                 245                 250                 255    
 Ser Thr Pro Ala Pro Gln Asp Met Gly Cys Leu Leu Pro Gly Pro Pro
             260                 265                 270        
 Leu Pro Phe Ala Glu Ala Glu Ser Leu Ala Ala Ala Gly Ser Asp Xaa
         275                 280                 285            
 Asp Gly Gly Gly Lys Gly Ala Leu Cys Leu Pro Gly Pro Ala Trp His
     290                 295                 300                
 Thr Pro Arg Pro Ala Arg Ala Gly Arg Cys Ile Ala Gly Ala Val Gln
 305                 310                 315                 320
 Ala Trp Leu Ile Trp Gly Leu Leu Gly Leu Thr Pro Asn Lys Glu Leu
                 325                 330                 335    
 Cys
    



      <210> 2701
      <211> 337
      <212> PRT
      <213> Homo sapiens

      <220>
      <221> misc_feature
      <222> (1)...(337)
      <223> Xaa = any amino acid or symbol as shown in the table 8 as set forth in Example 2


      <400> 2701
 Glu Phe Cys Ser Pro Thr Ser Pro Arg Pro Phe Phe Cys Pro Ile Ser
   1               5                  10                  15    
 Pro Glu Ser Val Ala Glu Ala Pro Val Phe Gly Ser Pro Ala Ile Thr
              20                  25                  30        
 Ala Pro Gln Met Gly Pro Gly Pro Met Pro Pro Asp Gly Leu Val Ala
          35                  40                  45            
 Ser Asp Pro Gly Ala Thr Ala Gly Ser Leu Pro Val Pro Ala Ala Ala
      50                  55                  60                
 Leu Asn Thr Gly Thr Gln Thr Thr Ser Ala Ala Ala Ala Ala Cys Asn
  65                  70                  75                  80
 Ala Ser Gly Arg Pro Pro Ala Arg Arg Pro Val Pro Ala Lys Gly His
                  85                  90                  95    
 Cys Pro Leu Thr Pro Gly Asn Pro Gly Ala Pro Ser Ser Gln Glu Arg
             100                 105                 110        
 Ser Ser Pro Ala Ser Ser Ile Ala Trp Arg Thr Pro Glu Pro Ala Pro
         115                 120                 125            
 Ser Ala Gly Leu Ala Glu Phe Pro Ser Ala Arg Gly Ala Gly Pro Ala
     130                 135                 140                
 Pro Asp Leu Gly Gly Asp Ser Asp Pro Pro Val Tyr Ser Ala Leu Ala
 145                 150                 155                 160
 Ser Leu Leu Ala Gln Gly Glu Ser Pro Thr Pro Ile Pro Ile Leu Ala
                 165                 170                 175    
 Trp Ser Ala Glu Ser Pro Thr Pro Thr Pro Leu Pro Pro Arg Ile Cys
             180                 185                 190        
 Pro Pro Gln Ala Pro Trp Arg Gln Gly Thr His Gly Arg Arg Pro Pro
         195                 200                 205            
 Thr Ser Thr Pro Glu Gln Gly Thr Val Gln Ser Gly Val Thr Thr Pro
     210                 215                 220                
 Val Ser Pro Pro Gly Xaa Ala Gly Gly Ala Gly Arg Ala Asp Cys Thr
 225                 230                 235                 240
 Ala Gly Pro Xaa Ala Trp Ala Arg Trp Gly Tyr Gly Pro Trp His Tyr
                 245                 250                 255    
 Ser Thr Pro Ala Pro Gln Asp Met Gly Cys Leu Leu Pro Gly Pro Pro
             260                 265                 270        
 Leu Pro Phe Ala Glu Ala Glu Ser Leu Ala Ala Ala Gly Ser Asp Xaa
         275                 280                 285            
 Asp Gly Gly Gly Lys Gly Ala Leu Cys Leu Pro Gly Pro Ala Trp His
     290                 295                 300                
 Thr Pro Arg Pro Ala Arg Ala Gly Arg Cys Ile Ala Gly Ala Val Gln
 305                 310                 315                 320
 Ala Trp Leu Ile Trp Gly Leu Leu Gly Leu Thr Pro Asn Lys Glu Leu
                 325                 330                 335    
 Cys
    



      <210> 2702
      <211> 48
      <212> PRT
      <213> Homo sapiens


      <400> 2702
 Met Ser Arg Met Ile Leu Phe Thr Val Leu Phe Arg Val Cys Ile Glu
   1               5                  10                  15    
 Ser Asp Ile Leu Tyr Met Leu Val Thr Cys Ile Met Thr Asn Ser Leu
              20                  25                  30        
 Ser Cys Pro Pro Gly Ser Ser Phe Ser Tyr Phe Leu Phe Leu Leu Ser
          35                  40                  45            





      <210> 2703
      <211> 60
      <212> PRT
      <213> Homo sapiens


      <400> 2703
 Met Cys Glu Val Ile Ser Ile Val Leu Val Leu Ile Gln Thr Ile Leu
   1               5                  10                  15    
 Asn Ile Leu Thr Ile Ser Lys Asp Leu Trp Pro Phe Phe Ala Glu Leu
              20                  25                  30        
 Ile Gly Lys Gly Thr Ile Asn Met Gln Tyr Val Thr His His Phe Asn
          35                  40                  45            
 Ile Leu Asn Leu Ala Ile Ala Leu Ile Ser Asn Asp
      50                  55                  60



      <210> 2704
      <211> 305
      <212> PRT
      <213> Homo sapiens


      <400> 2704
 Ser Ser Lys Thr Pro Ala Val Gly Arg Ser Cys Glu Gln Glu Pro Lys
   1               5                  10                  15    
 Met Phe Val Leu Leu Tyr Val Thr Ser Phe Ala Ile Cys Ala Ser Gly
              20                  25                  30        
 Gln Pro Arg Gly Asn Gln Leu Lys Gly Glu Asn Tyr Ser Pro Arg Tyr
          35                  40                  45            
 Ile Cys Ser Ile Pro Gly Leu Pro Gly Pro Pro Gly Pro Pro Gly Ala
      50                  55                  60                
 Asn Gly Ser Pro Gly Pro His Gly Arg Ile Gly Leu Pro Gly Arg Asp
  65                  70                  75                  80
 Gly Arg Asp Gly Arg Lys Gly Glu Lys Gly Glu Lys Gly Thr Ala Gly
                  85                  90                  95    
 Leu Arg Gly Lys Thr Gly Pro Leu Gly Leu Ala Gly Glu Lys Gly Asp
             100                 105                 110        
 Gln Gly Glu Thr Gly Lys Lys Gly Pro Ile Gly Pro Glu Gly Glu Lys
         115                 120                 125            
 Gly Glu Val Gly Pro Ile Gly Pro Pro Gly Pro Lys Gly Asp Arg Gly
     130                 135                 140                
 Glu Gln Gly Asp Pro Gly Leu Pro Gly Val Cys Arg Cys Gly Ser Ile
 145                 150                 155                 160
 Val Leu Lys Ser Ala Phe Ser Val Gly Ile Thr Thr Ser Tyr Pro Glu
                 165                 170                 175    
 Glu Arg Leu Pro Ile Ile Phe Asn Lys Val Leu Phe Asn Glu Gly Glu
             180                 185                 190        
 His Tyr Asn Pro Ala Thr Gly Lys Phe Ile Cys Ala Phe Pro Gly Ile
         195                 200                 205            
 Tyr Tyr Phe Ser Tyr Asp Ile Thr Leu Ala Asn Lys His Leu Ala Ile
     210                 215                 220                
 Gly Leu Val His Asn Gly Gln Tyr Arg Ile Lys Thr Phe Asp Ala Asn
 225                 230                 235                 240
 Thr Gly Asn His Asp Val Ala Ser Gly Ser Thr Val Ile Tyr Leu Gln
                 245                 250                 255    
 Pro Glu Asp Glu Val Trp Leu Glu Ile Phe Phe Thr Asp Gln Asn Gly
             260                 265                 270        
 Leu Phe Ser Asp Pro Gly Trp Ala Asp Ser Leu Phe Ser Gly Phe Leu
         275                 280                 285            
 Leu Tyr Val Asp Thr Asp Tyr Leu Asp Ser Ile Ser Glu Asp Asp Glu
     290                 295                 300                
 Leu
 305



      <210> 2705
      <211> 476
      <212> PRT
      <213> Homo sapiens

      <220>
      <221> misc_feature
      <222> (1)...(476)
      <223> Xaa = any amino acid or symbol as shown in the table 8 as set forth in Example 2


      <400> 2705
 His Leu Glu Asn Ile Val Tyr Tyr Lys Asp Asp Thr His Tyr Phe Val
   1               5                  10                  15    
 Met Thr Ala Lys Lys Gln Cys Leu Leu Arg Leu Gly Val Leu Arg Gln
              20                  25                  30        
 Asp Trp Pro Asp Thr Asn Arg Leu Leu Gly Ser Ala Asn Val Val Pro
          35                  40                  45            
 Glu Ala Leu Gln Arg Phe Thr Arg Ala Ala Ala Asp Phe Ala Thr His
      50                  55                  60                
 Gly Lys Leu Gly Lys Leu Glu Phe Ala Gln Asp Ala His Gly Gln Pro
  65                  70                  75                  80
 Asp Val Ser Ala Phe Asp Phe Thr Ser Met Met Arg Ala Glu Ser Ser
                  85                  90                  95    
 Ala Arg Val Gln Glu Lys His Gly Ala Arg Leu Leu Leu Gly Leu Val
             100                 105                 110        
 Gly Asp Cys Leu Val Glu Pro Phe Trp Pro Leu Gly Thr Gly Val Ala
         115                 120                 125            
 Arg Gly Phe Leu Ala Ala Phe Asp Ala Ala Trp Met Val Lys Arg Trp
     130                 135                 140                
 Ala Glu Gly Ala Glu Ser Leu Glu Val Leu Ala Glu Arg Glu Ser Leu
 145                 150                 155                 160
 Tyr Gln Leu Leu Ser Gln Thr Ser Pro Glu Asn Met His Arg Asn Val
                 165                 170                 175    
 Ala Gln Tyr Gly Leu Asp Pro Ala Thr Arg Tyr Pro Asn Leu Asn Leu
             180                 185                 190        
 Arg Ala Val Thr Pro Asn Gln Val Arg Asp Leu Tyr Asp Val Leu Ala
         195                 200                 205            
 Lys Glu Pro Val Gln Arg Asn Asn Asp Lys Thr Asp Thr Gly Met Pro
     210                 215                 220                
 Ala Thr Gly Ser Ala Gly Thr Gln Glu Glu Leu Leu Arg Trp Cys Gln
 225                 230                 235                 240
 Glu Gln Thr Ala Gly Tyr Pro Gly Val His Val Ser Asp Leu Ser Ser
                 245                 250                 255    
 Ser Trp Ala Asp Gly Leu Ala Leu Cys Ala Leu Val Tyr Arg Leu Gln
             260                 265                 270        
 Pro Gly Leu Leu Glu Pro Ser Xaa Leu Gln Gly Leu Gly Ala Leu Glu
         275                 280                 285            
 Ala Thr Ala Trp Ala Leu Lys Val Ala Glu Asn Glu Leu Gly Ile Thr
     290                 295                 300                
 Pro Val Val Ser Ala Gln Ala Val Val Ala Gly Ser Asp Pro Leu Gly
 305                 310                 315                 320
 Leu Ile Ala Tyr Leu Ser His Phe His Ser Ala Phe Lys Ser Met Ala
                 325                 330                 335    
 His Ser Pro Gly Pro Val Ser Gln Ala Ser Pro Gly Thr Ser Ser Ala
             340                 345                 350        
 Val Leu Phe Leu Ser Lys Leu Gln Arg Thr Leu Gln Arg Ser Arg Ala
         355                 360                 365            
 Lys Glu Asn Ala Glu Asp Ala Gly Gly Lys Lys Leu Arg Leu Glu Met
     370                 375                 380                
 Glu Ala Glu Thr Pro Ser Thr Glu Val Pro Pro Asp Pro Glu Pro Gly
 385                 390                 395                 400
 Val Pro Leu Thr Pro Pro Ser Gln His Gln Glu Ala Gly Ala Gly Asp
                 405                 410                 415    
 Leu Cys Ala Leu Cys Gly Glu His Leu Tyr Val Leu Glu Arg Leu Cys
             420                 425                 430        
 Val Asn Gly His Phe Phe His Arg Ser Cys Phe Arg Cys His Thr Cys
         435                 440                 445            
 Glu Ala Thr Leu Trp Pro Gly Gly Tyr Glu Gln His Pro Gly Asp Gly
     450                 455                 460                
 His Phe Tyr Tyr Leu Gln His Leu Pro His His Val
 465                 470                 475    



      <210> 2706
      <211> 76
      <212> PRT
      <213> Homo sapiens


      <400> 2706
 Leu Leu Gly Gly Val Pro Leu Arg Gly Asp Ala Gly Ser Thr Ser Val
   1               5                  10                  15    
 Pro Trp Pro Gly Ala Leu Leu Pro Ser Pro Gly His Thr Ala Thr Thr
              20                  25                  30        
 Ser Arg Ser Gln Cys Trp Glu Ala Gly Thr Met His Ser Glu Glu Gly
          35                  40                  45            
 Thr Cys Trp Leu Leu Glu Leu Leu Ser Glu Val Gln Leu Gln Gln Tyr
      50                  55                  60                
 Phe Leu Arg Leu Arg Asp Asp Leu Asn Val Thr Arg
  65                  70                  75    



      <210> 2707
      <211> 155
      <212> PRT
      <213> Homo sapiens


      <400> 2707
 Ser Trp Gly Ile Ile Leu Ser Phe Gly Asp Arg Ser Asn His Val Leu
   1               5                  10                  15    
 Glu Phe Phe Leu Leu Leu Leu Lys Tyr Leu Val Thr Ile Leu Thr Ser
              20                  25                  30        
 Lys Thr Met Gln Phe Pro Asn Val Lys Ile Leu Asp Met Leu Ser Ser
          35                  40                  45            
 Leu Phe Tyr Phe Tyr Leu Val Thr Gln Ser Asn Phe Trp Phe Thr Asp
      50                  55                  60                
 Val Cys Lys Pro Asp Ala Phe Cys Asp Gln Ala Arg Pro Pro Pro Val
  65                  70                  75                  80
 Gln Ser Tyr Met Asp Ala Ala Phe Leu Leu Asp Ala Ser Arg Asn Met
                  85                  90                  95    
 Gly Ser Ala Glu Phe Glu Asp Ile Arg Ala Phe Leu Gly Ala Leu Leu
             100                 105                 110        
 Asp His Phe Glu Ile Thr Pro Glu Pro Glu Thr Ser Val Thr Gly Asp
         115                 120                 125            
 Arg Val Ala Leu Leu Ser His Ala Pro Pro Asp Phe Leu Pro Asn Thr
     130                 135                 140                
 Gln Lys Ser Pro Val Arg Ala Glu Phe Asn Leu
 145                 150                 155



      <210> 2708
      <211> 465
      <212> PRT
      <213> Homo sapiens


      <400> 2708
 Ala Cys Leu Ile Cys Phe Arg Ile Gly Arg Gly Asn Cys Ser Arg Lys
   1               5                  10                  15    
 Ile Cys Glu Glu Phe Leu Asn Pro Gln Ile Leu Leu Thr Leu Glu Leu
              20                  25                  30        
 Val Val Thr Leu Ala Gly Lys Asn Lys Cys Arg Cys Trp Thr Met Leu
          35                  40                  45            
 Glu Thr Leu Ser Arg Gln Trp Ile Val Ser His Arg Met Glu Met Trp
      50                  55                  60                
 Leu Leu Ile Leu Val Ala Tyr Met Phe Gln Arg Asn Val Asn Ser Val
  65                  70                  75                  80
 His Met Pro Thr Lys Ala Val Asp Pro Glu Ala Phe Met Asn Ile Ser
                  85                  90                  95    
 Glu Ile Ile Gln His Gln Gly Tyr Pro Cys Glu Glu Tyr Glu Val Ala
             100                 105                 110        
 Thr Glu Asp Gly Tyr Ile Leu Ser Val Asn Arg Ile Pro Arg Gly Leu
         115                 120                 125            
 Val Gln Pro Lys Lys Thr Gly Ser Arg Pro Val Val Leu Leu Gln His
     130                 135                 140                
 Gly Leu Val Gly Gly Ala Ser Asn Trp Ile Ser Asn Leu Pro Asn Asn
 145                 150                 155                 160
 Ser Leu Gly Phe Ile Leu Ala Asp Ala Gly Phe Asp Val Trp Met Gly
                 165                 170                 175    
 Asn Ser Arg Gly Asn Ala Trp Ser Arg Lys His Lys Thr Leu Ser Ile
             180                 185                 190        
 Asp Gln Asp Glu Phe Trp Ala Phe Ser Tyr Asp Glu Met Ala Arg Phe
         195                 200                 205            
 Asp Leu Pro Ala Val Ile Asn Phe Ile Leu Gln Lys Thr Gly Gln Glu
     210                 215                 220                
 Lys Ile Tyr Tyr Val Gly Tyr Ser Gln Gly Thr Thr Met Gly Phe Ile
 225                 230                 235                 240
 Ala Phe Ser Thr Met Pro Glu Leu Ala Gln Lys Ile Lys Met Tyr Phe
                 245                 250                 255    
 Ala Leu Ala Pro Ile Ala Thr Val Lys His Ala Lys Ser Pro Gly Thr
             260                 265                 270        
 Lys Phe Leu Leu Leu Pro Asp Met Met Ile Lys Gly Leu Phe Gly Lys
         275                 280                 285            
 Lys Glu Phe Leu Tyr Gln Thr Arg Phe Leu Arg Gln Leu Val Ile Tyr
     290                 295                 300                
 Leu Cys Gly Gln Val Ile Leu Asp Gln Ile Cys Ser Asn Ile Met Leu
 305                 310                 315                 320
 Leu Leu Gly Gly Phe Asn Thr Asn Asn Met Asn Met Ser Arg Ala Ser
                 325                 330                 335    
 Val Tyr Ala Ala His Thr Leu Ala Gly Thr Ser Val Gln Asn Ile Leu
             340                 345                 350        
 His Trp Ser Gln Ala Val Asn Ser Gly Glu Leu Arg Ala Phe Asp Trp
         355                 360                 365            
 Gly Ser Glu Thr Lys Asn Leu Glu Lys Cys Asn Gln Pro Thr Pro Val
     370                 375                 380                
 Arg Tyr Arg Val Arg Asp Met Thr Val Pro Thr Ala Met Trp Thr Gly
 385                 390                 395                 400
 Gly Gln Asp Trp Leu Ser Asn Pro Glu Asp Val Lys Met Leu Leu Ser
                 405                 410                 415    
 Glu Val Thr Asn Leu Ile Tyr His Lys Asn Ile Pro Glu Trp Ala His
             420                 425                 430        
 Val Asp Phe Ile Trp Gly Leu Asp Ala Pro His Arg Met Tyr Asn Glu
         435                 440                 445            
 Ile Ile His Leu Met His Gln Glu Glu Thr Gln Pro Phe Pro Arg Thr
     450                 455                 460                
 Ala
 465



      <210> 2709
      <211> 71
      <212> PRT
      <213> Homo sapiens


      <400> 2709
 Met Val Pro Cys Ser Gly Leu Cys Pro Leu Gly Gly Ser Trp Pro Phe
   1               5                  10                  15    
 Leu Tyr Ser Leu Gly Cys Ser Ser Trp Ala Lys Leu Ser Phe Leu Thr
              20                  25                  30        
 Cys Cys Leu Trp Val Asp Gly Ser Arg Pro Gly Pro Val Leu Ser Glu
          35                  40                  45            
 Pro Glu Ala Ser Leu Gln Ala His Gly Leu Cys Thr Leu Pro Ser Lys
      50                  55                  60                
 Met Trp Gln Ser Leu Tyr Phe
  65                  70    



      <210> 2710
      <211> 202
      <212> PRT
      <213> Homo sapiens


      <400> 2710
 Met Glu Leu Trp Gly Ala Tyr Leu Leu Leu Cys Leu Phe Ser Leu Leu
   1               5                  10                  15    
 Thr Gln Val Thr Thr Glu Pro Pro Thr Gln Lys Pro Lys Lys Ile Val
              20                  25                  30        
 Asn Ala Lys Lys Asp Val Val Asn Thr Lys Met Phe Glu Glu Leu Lys
          35                  40                  45            
 Ser Arg Leu Asp Thr Leu Ala Gln Glu Val Ala Leu Leu Lys Glu Gln
      50                  55                  60                
 Gln Ala Leu Gln Thr Val Cys Leu Lys Gly Thr Lys Val His Met Lys
  65                  70                  75                  80
 Cys Phe Leu Ala Phe Thr Gln Thr Lys Thr Phe His Glu Ala Ser Glu
                  85                  90                  95    
 Asp Cys Ile Ser Arg Gly Gly Thr Leu Ser Thr Pro Gln Thr Gly Ser
             100                 105                 110        
 Glu Asn Asp Ala Leu Tyr Glu Tyr Leu Arg Gln Ser Val Gly Asn Glu
         115                 120                 125            
 Ala Glu Ile Trp Leu Gly Leu Asn Asp Met Ala Ala Glu Gly Thr Trp
     130                 135                 140                
 Val Asp Met Thr Gly Ala Arg Ile Ala Tyr Lys Asn Trp Glu Thr Glu
 145                 150                 155                 160
 Ile Thr Ala Gln Pro Asp Gly Gly Lys Thr Glu Asn Cys Ala Val Leu
                 165                 170                 175    
 Ser Gly Ala Ala Asn Gly Lys Trp Phe Asp Lys Arg Cys Arg Asp Gln
             180                 185                 190        
 Leu Pro Tyr Ile Cys Gln Phe Gly Ile Val
         195                 200        



      <210> 2711
      <211> 185
      <212> PRT
      <213> Homo sapiens


      <400> 2711
 Val Pro Gly Thr Gln Lys Ala Met Trp Thr Ser Thr Asn Leu His Ser
   1               5                  10                  15    
 Pro Gly Ser Ile Pro Ala Gly Leu Trp Leu Ala Met Arg Thr Gly Gly
              20                  25                  30        
 Tyr Leu Glu Gly Ser Ile Leu Ile Pro Asp Ala Ile Leu Gly Leu Glu
          35                  40                  45            
 Glu Val Arg Leu Thr Pro Ser Met Arg Asn Arg Ser Gly Ala Val Trp
      50                  55                  60                
 Ser Arg Ala Ser Val Pro Phe Ser Ala Trp Glu Val Glu Val Gln Met
  65                  70                  75                  80
 Arg Val Thr Gly Leu Gly Arg Arg Gly Ala Gln Gly Met Ala Val Trp
                  85                  90                  95    
 Tyr Thr Arg Gly Arg Gly His Val Gly Ser Val Leu Gly Gly Leu Ala
             100                 105                 110        
 Ser Trp Asp Gly Ile Gly Ile Phe Phe Asp Ser Pro Ala Glu Asp Thr
         115                 120                 125            
 Gln Asp Ser Pro Ala Ile Arg Val Leu Ala Ser Asp Gly His Ile Pro
     130                 135                 140                
 Ser Glu Gln Pro Gly Asp Gly Ala Ser Gln Gly Leu Gly Ser Cys His
 145                 150                 155                 160
 Trp Asp Phe Arg Asn Arg Pro His Pro Phe Arg Ala Arg Ile Thr Tyr
                 165                 170                 175    
 Trp Gly Gln Arg Leu Arg Val Ser His
             180                 185



      <210> 2712
      <211> 93
      <212> PRT
      <213> Homo sapiens


      <400> 2712
 Leu Glu Arg Lys Leu Phe Tyr Pro Glu Cys Glu Ile Arg Thr Met Gly
   1               5                  10                  15    
 Gly Arg Glu Gln Arg Gln Ser Pro Gly Ala Gln Arg Thr Phe Phe Gln
              20                  25                  30        
 Leu Leu Leu Ser Phe Phe Val Glu Ser Lys Leu His Asp His Ala Ala
          35                  40                  45            
 Tyr Leu Val Asp Asn Leu Trp Asp Cys Ala Gly Thr Gln Leu Lys Asp
      50                  55                  60                
 Trp Glu Gly Leu Thr Ser Leu Leu Leu Glu Lys Asp Gln Ser Thr Cys
  65                  70                  75                  80
 His Met Glu Pro Gly Pro Gly Thr Phe His Leu Leu Gly
                  85                  90            



      <210> 2713
      <211> 56
      <212> PRT
      <213> Homo sapiens


      <400> 2713
 Met Gln Glu Ser Asn Ile Tyr Phe Leu Ser Ile Cys Phe Lys Thr Ser
   1               5                  10                  15    
 Trp Cys Leu Phe Leu Leu Ala Thr Gly His Leu Tyr Tyr Cys Asn Ser
              20                  25                  30        
 Gln Thr Leu Trp Gln Tyr Thr Glu His Cys Tyr Asp Ser Leu Phe Phe
          35                  40                  45            
 Asn Thr Phe Val Leu Ser Phe Ser
      50                  55    



      <210> 2714
      <211> 72
      <212> PRT
      <213> Homo sapiens


      <400> 2714
 Met Asn Val Thr Ala Ile Trp Leu His Arg Asp Lys Leu Phe Cys Trp
   1               5                  10                  15    
 Leu Val Ile Ser Tyr Ile Ser Glu Ile Cys Leu Ser Glu Cys Trp Ile
              20                  25                  30        
 Lys Ile Ala Val Phe Lys Asn Ser Leu Phe Lys Asn Val Leu Gln Tyr
          35                  40                  45            
 Tyr Ile Leu Thr Asp Leu Cys Leu Ser Gln Leu Leu Met Asn Asn Leu
      50                  55                  60                
 Tyr Ser Leu Glu Ser Tyr Ile Lys
  65                  70        



      <210> 2715
      <211> 81
      <212> PRT
      <213> Homo sapiens


      <400> 2715
 Met Pro Thr Cys Phe Leu Arg Tyr Pro Phe Leu Leu Ile Phe Phe Leu
   1               5                  10                  15    
 Ala Gln Leu Leu Tyr Ile Trp Thr Ser Leu Tyr Cys Pro Pro Phe Leu
              20                  25                  30        
 Ser Asn Leu Ser Leu Pro Tyr Ser Ser Ala Leu Ser Pro Leu Leu Ile
          35                  40                  45            
 Leu His Val Cys Pro Val Ala Ala His Leu Leu Phe Ser Ser Thr Thr
      50                  55                  60                
 Thr Tyr Met Pro Leu Ile Pro Leu Glu Ile Cys Ile Ser Ser Leu Glu
  65                  70                  75                  80
 Ile
    



      <210> 2716
      <211> 56
      <212> PRT
      <213> Homo sapiens


      <400> 2716
 Met Pro Val Pro Leu Ala Arg Ile Cys Trp Val Ser Phe Leu His Gln
   1               5                  10                  15    
 Ala Pro Cys Trp Glu Leu Cys Tyr Tyr Cys Val Val Leu Thr Ser Ala
              20                  25                  30        
 Leu Ile Gly Ala Val Asn Ser Ser Ile Leu Gln Met Thr Gly Ser Thr
          35                  40                  45            
 Gly Arg Leu Asp Ser Trp Pro Trp
      50                  55    



      <210> 2717
      <211> 70
      <212> PRT
      <213> Homo sapiens


      <400> 2717
 Met Val Leu Cys Ser Ser Ala Phe Leu Thr Val Gln Trp Gly Gly Glu
   1               5                  10                  15    
 Ala Ser Asp Asn Ile Tyr Leu Ala Phe Tyr Phe Ser Val Cys Gly Phe
              20                  25                  30        
 Thr Ile Ser Leu Thr Leu Thr Pro Ser Arg His Leu Lys Gly Cys Val
          35                  40                  45            
 Glu Ala Arg Leu Ser Glu Ser Gly Glu Gly Glu Lys Gly Trp Gln Glu
      50                  55                  60                
 Gly Leu Val Ser Gly Ala
  65                  70



      <210> 2718
      <211> 79
      <212> PRT
      <213> Homo sapiens


      <400> 2718
 Ala Arg Pro Ser Cys Pro Cys Ser Trp Ser Phe Ser Cys Cys Gly Val
   1               5                  10                  15    
 Ser Pro Gly Ala Leu Val Thr Glu Ala Ala Ile Phe Tyr Glu Thr Gln
              20                  25                  30        
 Pro Ser Leu Trp Ala Glu Ser Glu Ser Leu Leu Lys Pro Leu Ala Lys
          35                  40                  45            
 Leu Met Thr Tyr Phe Lys Asn Ser Thr Tyr Leu Ile Arg Leu Phe Met
      50                  55                  60                
 Ile Tyr Arg Cys Lys Pro Val Lys Ser Lys Lys Lys Lys Arg Asn
  65                  70                  75                



      <210> 2719
      <211> 51
      <212> PRT
      <213> Homo sapiens


      <400> 2719
 Met Glu Ile Thr Lys Ser Trp Phe Val Phe Leu Trp Leu Ile Lys Phe
   1               5                  10                  15    
 Leu Glu Asn Arg Asp Thr Tyr Val Ser Phe Phe Ala Asp Leu Lys Lys
              20                  25                  30        
 Ile Val Arg Glu Ile Arg Cys Val Ile Ile Ile Ser Ser Ala Leu Ala
          35                  40                  45            
 Arg Ile Met
      50    



      <210> 2720
      <211> 45
      <212> PRT
      <213> Homo sapiens


      <400> 2720
 Met Ser Val Phe Phe Leu Ser Cys Leu Ile Leu Pro Gln Pro Gly Pro
   1               5                  10                  15    
 Ile Ala Ala Gly Val Arg Cys Tyr Ser Trp Thr Pro Pro Leu Val Arg
              20                  25                  30        
 Gly Asp Leu Ala Gly Lys Val Ala Cys Asp Val His Pro
          35                  40                  45



      <210> 2721
      <211> 71
      <212> PRT
      <213> Homo sapiens


      <400> 2721
 Met Tyr Thr His Phe Phe Ser Ile Trp Leu Leu Gly Ile Leu Thr Lys
   1               5                  10                  15    
 Ile Glu Asn Cys Pro Phe Ser Val Arg Tyr Gly Ile Ser Cys His Thr
              20                  25                  30        
 Asp Phe Leu Arg Leu Tyr Ile Gln Leu Cys Leu Glu Val Pro Ile Phe
          35                  40                  45            
 Ala Gln Trp Ile Glu Asn Ile Leu Phe Ala Ile Tyr Gln Lys Arg His
      50                  55                  60                
 Val Leu Pro Thr Tyr Val Arg
  65                  70    



      <210> 2722
      <211> 45
      <212> PRT
      <213> Homo sapiens


      <400> 2722
 Met His Cys Thr Phe Leu Ser Val Leu Ala Leu Pro Val Ile Val Arg
   1               5                  10                  15    
 Ile Leu Lys Ser Trp Ser Ser Cys Leu Trp Glu Gly Asn Leu Val His
              20                  25                  30        
 Val Lys Cys Leu Lys Phe Pro Val Leu Ser His Gly Ser
          35                  40                  45



      <210> 2723
      <211> 45
      <212> PRT
      <213> Homo sapiens


      <400> 2723
 Met His Cys Thr Phe Leu Ser Val Leu Ala Leu Pro Val Ile Val Arg
   1               5                  10                  15    
 Ile Leu Lys Ser Trp Ser Ser Cys Leu Trp Glu Gly Asn Leu Val His
              20                  25                  30        
 Val Lys Cys Leu Lys Phe Pro Val Leu Ser His Gly Ser
          35                  40                  45



      <210> 2724
      <211> 47
      <212> PRT
      <213> Homo sapiens


      <400> 2724
 Met His Val Leu Phe Thr Leu Tyr Leu Val Pro Cys Cys Leu His Phe
   1               5                  10                  15    
 Glu Leu Phe Ile Gly Asp Leu Ala Val Lys Asn Gly Thr Lys His Ser
              20                  25                  30        
 Ala Glu Val Leu Ser Arg Val Pro Lys His Lys Lys Ala Val Arg
          35                  40                  45        



      <210> 2725
      <211> 62
      <212> PRT
      <213> Homo sapiens


      <400> 2725
 Met Lys Cys Phe Leu Phe Val Cys Leu Phe Val Cys Phe Ser Glu Lys
   1               5                  10                  15    
 Leu Asp Leu Gly Ala Ser Phe Phe Ser Leu Ser Ala Pro Leu Ala Phe
              20                  25                  30        
 Gly Val Arg Phe Ser Trp Ser Cys Leu Pro Arg Asn Ser Ala Val His
          35                  40                  45            
 Val Leu Val Met Arg Asp Thr Lys Ala Asn Met Pro Cys Ser
      50                  55                  60        



      <210> 2726
      <211> 71
      <212> PRT
      <213> Homo sapiens


      <400> 2726
 Met Gly Arg Leu Phe Pro Leu Val Leu Leu Leu Phe Pro Val Thr Asn
   1               5                  10                  15    
 Ser Val Ser Pro Thr Ala Leu Leu Val Leu Val Thr Thr Gly Gly Ser
              20                  25                  30        
 Gly Pro Ala Thr Met Val Leu Leu Pro Ala Pro Val Met Gly Arg Ile
          35                  40                  45            
 Pro Asn His Cys Leu Ser Lys Ser Ser Arg Gln Ser Pro Ser Pro Arg
      50                  55                  60                
 Cys Asp Lys Pro Glu Val Pro
  65                  70    



      <210> 2727
      <211> 57
      <212> PRT
      <213> Homo sapiens


      <400> 2727
 Met Thr Ala Gln His His Ser Ile Ala Val Leu Leu Leu Asn Leu Glu
   1               5                  10                  15    
 Val Thr Cys Glu Cys Met Glu Tyr Asn Lys Val Phe Tyr Ser Gly Ser
              20                  25                  30        
 Phe Ala Ser Thr Ser Phe Leu Ile Gly Tyr Cys Ser Ser Ser Ser Gly
          35                  40                  45            
 Phe Tyr Phe Val Gln Pro Ser Arg Pro
      50                  55        



      <210> 2728
      <211> 163
      <212> PRT
      <213> Homo sapiens


      <400> 2728
 Met Leu Thr Leu Phe Ala Ala Met Leu Ser Cys Gly Ile His Leu Gln
   1               5                  10                  15    
 Arg Leu Ile Gln Glu Lys Gly Phe Val Ser Thr Ile Ile Arg Leu Leu
              20                  25                  30        
 Asp Ser Pro Ser Thr Cys Ile Arg Ala Lys Ala Phe Leu Val Leu Leu
          35                  40                  45            
 Tyr Ile Leu Ile Tyr Asn Arg Glu Met Leu Leu Leu Ser Cys Gln Ala
      50                  55                  60                
 Arg Leu Val Met Tyr Ile Glu Arg Asp Ser Arg Lys Thr Thr Pro Gly
  65                  70                  75                  80
 Lys Glu Gln Gln Ser Gly Asn Glu Tyr Leu Ser Lys Cys Leu Asp Leu
                  85                  90                  95    
 Leu Ile Cys His Ile Val Gln Glu Leu Pro Arg Ile Leu Gly Asp Ile
             100                 105                 110        
 Leu Asn Ser Leu Ala Asn Val Ser Gly Arg Lys His Pro Ser Thr Val
         115                 120                 125            
 Gln Val Lys Gln Leu Lys Leu Cys Leu Pro Leu Met Pro Val Val Leu
     130                 135                 140                
 His Leu Val Thr Ser Gln Val Phe Arg Thr Gln Val Gly Asn Lys Arg
 145                 150                 155                 160
 Val Ser Phe
            



      <210> 2729
      <211> 59
      <212> PRT
      <213> Homo sapiens


      <400> 2729
 Met Val Ala Ser Phe Arg Glu Ser Arg Val Leu Leu Leu Gly Leu Val
   1               5                  10                  15    
 Val Arg Val Leu Thr Phe Asp Phe Leu Thr Gln Val Val Arg Val Gly
              20                  25                  30        
 Ser Glu Cys Gly Asp Glu Leu Val Arg Leu Tyr Ser Phe Thr Asp Glu
          35                  40                  45            
 Lys Ala Asn Tyr Leu Gln Gln Gly Gly Cys Arg
      50                  55                



      <210> 2730
      <211> 48
      <212> PRT
      <213> Homo sapiens


      <400> 2730
 Met Ser Glu Phe Leu Cys Phe Phe Thr Gln Arg Ala Ile Val Thr Thr
   1               5                  10                  15    
 Phe Ser Leu Ser Thr Thr Glu Gly Asn Ser Cys Ala Thr Trp Leu Cys
              20                  25                  30        
 Val Pro Phe Pro Gly Cys Ser Val Leu Trp Ser Val Leu Asp Arg Lys
          35                  40                  45            





      <210> 2731
      <211> 46
      <212> PRT
      <213> Homo sapiens


      <400> 2731
 Met Gly Phe Leu Cys Glu Ile Gly Ala Ile Pro Thr Met Val Leu Ala
   1               5                  10                  15    
 Leu Trp Gly Phe Leu Arg Ala Ser Ser Ala Ser Pro Pro Ser Leu Asn
              20                  25                  30        
 Arg Leu Pro Gly Gln Gly Ser Ala Phe Ser Phe Gln Ile Cys
          35                  40                  45    



      <210> 2732
      <211> 57
      <212> PRT
      <213> Homo sapiens


      <400> 2732
 Met Phe Ile Phe Lys Thr Lys Gly Ile Leu Leu Pro Cys Gln Lys Met
   1               5                  10                  15    
 Leu Gln Ile Val Phe Phe Phe Leu Pro Lys Asn Thr Leu Ser Ser Met
              20                  25                  30        
 Phe Tyr Phe Ser Asp Cys Ile Gly Val His Lys Tyr Met His Ile Leu
          35                  40                  45            
 Ile Tyr Ile His Thr Tyr Val Ser Leu
      50                  55        



      <210> 2733
      <211> 56
      <212> PRT
      <213> Homo sapiens


      <400> 2733
 Met His Leu Phe Phe His Thr Leu Thr Ser Leu Arg Leu Gly Cys Ile
   1               5                  10                  15    
 Ile Gln Ser Leu Leu Ala Arg Gly Ala Ser Cys Cys Tyr Cys His His
              20                  25                  30        
 Met Asn Ile Arg Ile Cys Glu Trp Met Ser Ala Ala Gln Lys Glu Ile
          35                  40                  45            
 Pro Glu Ile Val Val Glu His Pro
      50                  55    



      <210> 2734
      <211> 57
      <212> PRT
      <213> Homo sapiens


      <400> 2734
 Met Cys Leu Arg Arg Thr Leu Leu Trp His Leu His Ile Ala Pro Leu
   1               5                  10                  15    
 Val Asn Ile Leu Ser Asp Tyr Lys Pro Leu Gly Arg Trp Asn His Ala
              20                  25                  30        
 Pro Ala Leu Thr Ala Gly Ala Leu His Lys Thr Thr Ile Leu Leu Pro
          35                  40                  45            
 Gln Gly His Pro Lys Ala Ala Asn Pro
      50                  55        



      <210> 2735
      <211> 54
      <212> PRT
      <213> Homo sapiens


      <400> 2735
 Met Leu Val Phe Asn Leu Ser Leu Val Leu Ser His Ser Val Leu Glu
   1               5                  10                  15    
 Phe Val Met Phe Leu Tyr Ser Leu Asp Ser Ser His Val Cys Pro Leu
              20                  25                  30        
 Val Val Pro Val Thr Leu Asp Leu Ile Tyr Leu Val Tyr Leu Pro Cys
          35                  40                  45            
 Gln Ser Tyr Ile Leu Ile
      50                



      <210> 2736
      <211> 50
      <212> PRT
      <213> Homo sapiens


      <400> 2736
 Met Ser Leu Asn Pro Glu Phe Leu Trp Leu Lys Trp Phe Ser Leu Leu
   1               5                  10                  15    
 Leu Arg Gly Arg Arg Asn Ser Cys Leu Ile Ala Leu Lys Gly Tyr His
              20                  25                  30        
 Ser Val Met Ile Phe His Leu Pro Leu Ile Pro Ser Ser Val Thr Ser
          35                  40                  45            
 Cys His
      50



      <210> 2737
      <211> 83
      <212> PRT
      <213> Homo sapiens


      <400> 2737
 Met Gly Leu Asn Ile Pro Gly Leu Trp Ser Leu Ser Ser Val Leu Ser
   1               5                  10                  15    
 Leu Thr Gly Leu Thr Ser Pro Val Val Phe Leu Gly Ser Arg Glu Gln
              20                  25                  30        
 Asn Pro Leu Ala Lys Arg Leu Ala Leu Lys Glu Leu Leu Pro Phe Thr
          35                  40                  45            
 His Ser Gln Gln Ser Ser Ser Glu Leu Pro Leu Arg Pro Pro Arg Ala
      50                  55                  60                
 Ala Arg Arg Pro Cys Gln Pro Asn Ser Val Gly Gly Thr Gly His Ala
  65                  70                  75                  80
 Ala Arg Cys
            



      <210> 2738
      <211> 92
      <212> PRT
      <213> Homo sapiens


      <400> 2738
 Met Glu Ala Glu Thr Pro Cys Thr Ile Phe Thr Phe Ser Pro Ser Leu
   1               5                  10                  15    
 Lys Tyr Arg Phe Trp Leu Leu Leu Leu Phe Ser Met Ala Ser Ser Glu
              20                  25                  30        
 Pro Met Pro Gln Tyr Phe Leu Ser Cys Thr Leu Ser Glu Lys Lys Tyr
          35                  40                  45            
 Ser Pro Leu Gly Leu Arg Gly Gly Gly Gln Gln Gly Ala His His His
      50                  55                  60                
 Cys Gly Gly Ser Lys Gly Gln Gly Leu Asp His Val Pro His Gly Leu
  65                  70                  75                  80
 Asp Ala Thr Ser Ala Met Met Asp Thr Pro Lys Cys
                  85                  90        



      <210> 2739
      <211> 106
      <212> PRT
      <213> Homo sapiens


      <400> 2739
 Met Lys Pro Phe Thr Val Leu Lys Gly Phe His Phe Ser Val Phe Cys
   1               5                  10                  15    
 Leu Leu Pro Leu Ile Thr His Asn Ile Asn Leu Gln Thr Thr Trp Gln
              20                  25                  30        
 Ile Pro Ser Leu Ile Ser Arg Ala Pro Ser Ser Phe Ser Gln Ala Gly
          35                  40                  45            
 His Leu Leu Lys Ala Leu Leu Gly Ser Pro Gly Arg Glu Ala Ser Leu
      50                  55                  60                
 Cys Phe Thr Pro Thr His Ala Cys Ser Pro Leu Pro Trp Glu Lys Ala
  65                  70                  75                  80
 Val Pro Gly Trp Pro Met Val Thr Val Lys Arg Ser Tyr Leu Thr Met
                  85                  90                  95    
 Gln Val Ala Ile Pro Leu Ser Ser Trp Leu
             100                 105    



      <210> 2740
      <211> 425
      <212> PRT
      <213> Homo sapiens

      <220>
      <221> misc_feature
      <222> (1)...(425)
      <223> Xaa = any amino acid or symbol as shown in the table 8 as set forth in Example 2


      <400> 2740
 Thr His Pro Gln Glu Arg Gly Thr Trp Gly Asn Arg Gln Leu Phe Ala
   1               5                  10                  15    
 Val Leu Pro Leu Pro Phe Tyr Thr Ser Leu Glu Thr Met Ser Met Gly
              20                  25                  30        
 Cys Gly Ala Val Val Ala Gly Gln Tyr Gln Lys Cys Pro Phe Phe Thr
          35                  40                  45            
 Ile Pro Ser Ala Asn Phe Pro Trp Gln Lys Gln Glu Gly Met Ser Gly
      50                  55                  60                
 Asn Pro Pro Arg Val Arg Arg His Ile Ser Leu Ser Arg Ser Cys Leu
  65                  70                  75                  80
 Thr Leu Ala Val Pro Met Thr Ile Arg Arg Ser Trp Glu Gly Ala Pro
                  85                  90                  95    
 Phe Val Gly Ala Gln Asp Gly Cys Arg Pro Leu Leu Pro Gly Arg Arg
             100                 105                 110        
 Ala Leu Leu Leu His Leu Gly Leu Ala Pro Leu Leu Gly Pro Pro Pro
         115                 120                 125            
 Pro Pro Val Ser Pro Pro Trp Pro Pro Cys Lys Ala Thr Trp Val Ser
     130                 135                 140                
 Ala Gly Gly Arg Cys Leu Tyr Gly Cys Pro Ser Ala Pro Ala Pro Arg
 145                 150                 155                 160
 Ala Pro Pro Glu Phe Pro Ala Pro Pro Gly Phe Pro Ala Pro Pro Ala
                 165                 170                 175    
 Ala Ser Ser Pro Ser Thr Arg Cys Ser Arg Gly Thr Xaa Ser Cys Gly
             180                 185                 190        
 Pro Gly Arg Pro Gly Pro Leu Gly Pro Ala Trp Ser Ala Gly Gln Arg
         195                 200                 205            
 Gly Gln Leu Ala Val Pro Glu Pro Leu Gln Ala Val Leu Gly Ala Leu
     210                 215                 220                
 Gly Leu Leu Arg Pro Leu Gly Glu Arg Arg Pro Ala Gln Ala Gly Thr
 225                 230                 235                 240
 Phe Ser Pro Thr Ala Pro Gly Arg Gly Ala Pro Gly Ala Ser Ala Xaa
                 245                 250                 255    
 Gly Gly Arg Ile Ser Gly His Ser Ser Gly Asp Ile Pro Arg Arg Gly
             260                 265                 270        
 Pro Ser Arg Gly His Pro Pro Leu Leu Ala Gln Gly Ser Asp Ala Ile
         275                 280                 285            
 Arg Ser Thr Leu His Glu Arg Leu Ser Thr Arg Thr Arg Pro Ser Phe
     290                 295                 300                
 Lys Ile Lys Thr Pro Ser Pro His Gln Arg Pro Gln Gln Pro His Ala
 305                 310                 315                 320
 Ser Trp Thr Pro Ser Ser Gly Thr Leu Ser Lys Pro Ser Thr Pro Cys
                 325                 330                 335    
 Ser Ser Ser Ser Cys Ala Pro Arg Ser Gly Asp Gly Gly Gly Glu Gly
             340                 345                 350        
 His Ala Gly Leu Pro Ser Gln Pro Ala Ala Gly Ser Gln Pro Ala Ala
         355                 360                 365            
 Pro Cys Gln Arg Pro Glu Ala Trp Ala Gly Gly Arg Gly Asn Arg Pro
     370                 375                 380                
 Gly Lys Pro Gly Ala Pro Gln Gly Pro Cys Phe Ser Leu Pro Arg Pro
 385                 390                 395                 400
 Gln Arg Ser Arg Xaa Leu Pro Pro Pro Ala Arg Gln Lys Pro Pro Phe
                 405                 410                 415    
 Phe Thr Leu Leu Ser Leu Phe Ser Phe
             420                 425



      <210> 2741
      <211> 144
      <212> PRT
      <213> Homo sapiens


      <400> 2741
 Arg Val Asp Pro Arg Val Arg Ala Pro Arg Cys Gly Asp Lys Ile Lys
   1               5                  10                  15    
 Asn His Met Tyr Lys Cys Asp Cys Gly Ser Leu Lys Asp Cys Ala Ser
              20                  25                  30        
 Asp Arg Cys Cys Glu Thr Ser Cys Thr Leu Ser Leu Gly Ser Val Cys
          35                  40                  45            
 Asn Thr Gly Leu Cys Cys His Lys Cys Lys Tyr Ala Ala Pro Gly Val
      50                  55                  60                
 Val Cys Arg Asp Leu Gly Gly Ile Cys Asp Leu Pro Glu Tyr Cys Asp
  65                  70                  75                  80
 Gly Lys Lys Glu Glu Cys Pro Asn Asp Ile Tyr Ile Gln Asp Gly Thr
                  85                  90                  95    
 Pro Cys Ser Ala Val Ser Val Cys Ile Arg Gly Asn Cys Ser Asp Arg
             100                 105                 110        
 Asp Met Gln Cys Gln Ala Leu Phe Gly Tyr Gln Val Lys Asp Gly Ser
         115                 120                 125            
 Pro Ala Cys Tyr Arg Lys Leu Asn Arg Ile Gly Asn Arg Phe Gly Thr
     130                 135                 140                





      <210> 2742
      <211> 285
      <212> PRT
      <213> Homo sapiens


      <400> 2742
 Asp Ile Ala Leu Ser Ser Trp Pro Cys Pro Leu Ala Ser Arg Ala Pro
   1               5                  10                  15    
 Pro Thr Met Arg Ser Ser Cys Val Leu Leu Thr Ala Leu Val Ala Leu
              20                  25                  30        
 Ala Ala Tyr Tyr Val Tyr Ile Pro Leu Pro Gly Ser Val Ser Asp Pro
          35                  40                  45            
 Trp Lys Leu Met Leu Leu Asp Ala Thr Phe Arg Gly Ala Gln Lys Val
      50                  55                  60                
 Ser Asn Leu Ile His Tyr Leu Gly Leu Gly His His Leu Leu Ala Leu
  65                  70                  75                  80
 Asn Phe Ile Ile Val Ser Phe Gly Lys Lys Ser Ala Trp Ser Ser Ala
                  85                  90                  95    
 Gln Val Lys Val Thr Asp Thr Asp Phe Asp Gly Val Glu Val Arg Val
             100                 105                 110        
 Phe Glu Gly Pro Pro Lys Pro Glu Glu Pro Leu Lys Arg Ser Val Val
         115                 120                 125            
 Tyr Ile His Gly Gly Gly Trp Ala Leu Ala Ser Ala Lys Ile Arg Tyr
     130                 135                 140                
 Tyr Asp Glu Leu Cys Thr Ala Met Ala Glu Glu Leu Asn Ala Val Ile
 145                 150                 155                 160
 Val Ser Ile Glu Tyr Arg Leu Val Pro Lys Val Tyr Phe Pro Glu Gln
                 165                 170                 175    
 Ile His Asp Val Val Arg Ala Thr Lys Tyr Phe Leu Lys Pro Glu Val
             180                 185                 190        
 Leu Gln Lys Tyr Met Val Asp Pro Gly Arg Ile Cys Ile Ser Gly Asp
         195                 200                 205            
 Ser Ala Gly Gly Asn Leu Ala Ala Ala Leu Gly Gln Gln Phe Thr Gln
     210                 215                 220                
 Asp Ala Ser Leu Lys Asn Lys Leu Lys Leu Gln Ala Leu Ile Tyr Pro
 225                 230                 235                 240
 Val Leu Gln Ala Leu Asp Phe Asn Thr Pro Ser Tyr Gln Gln Asn Val
                 245                 250                 255    
 Asn Thr Pro Ile Leu Pro Arg Tyr Val Met Val Lys Tyr Trp Val Asp
             260                 265                 270        
 Tyr Phe Lys Gly Asn Tyr Asp Phe Val Gln Ala Met Ile
         275                 280                 285



      <210> 2743
      <211> 148
      <212> PRT
      <213> Homo sapiens

      <220>
      <221> misc_feature
      <222> (1)...(148)
      <223> Xaa = any amino acid or symbol as shown in the table 8 as set forth in Example 2


      <400> 2743
 Thr Leu Leu Ser Asn Leu Glu Glu Ala Lys Lys Lys Lys Glu Asp Ala
   1               5                  10                  15    
 Leu Asn Glu Thr Arg Glu Ser Xaa Thr Lys Leu Lys Glu Leu Pro Gly
              20                  25                  30        
 Val Cys Asn Glu Thr Met Met Ala Leu Trp Glu Glu Cys Lys Pro Cys
          35                  40                  45            
 Leu Lys Gln Thr Cys Met Lys Ile Tyr Ala Arg Val Cys Ile Ser Gly
      50                  55                  60                
 Ser Gly Leu Val Gly Arg Gln Leu Glu Glu Phe Leu Asn Gln Ser Ser
  65                  70                  75                  80
 Pro Phe Tyr Phe Trp Met Asn Gly Asp Arg Ile Asp Ser Leu Leu Glu
                  85                  90                  95    
 Asn Asp Arg Gln Gln Thr His Met Leu Asp Val Met Gln Asp His Phe
             100                 105                 110        
 Ser Arg Ala Phe Ser Ile Ile Asp Glu Leu Phe Gln Asp Arg Phe Phe
         115                 120                 125            
 Thr Arg Glu Pro Gln Asp Thr Tyr His Tyr Leu Pro Phe Ser Leu Pro
     130                 135                 140                
 His Arg Arg Pro
 145            



      <210> 2744
      <211> 93
      <212> PRT
      <213> Homo sapiens


      <400> 2744
 Ile Gln Gly Met His Phe Ala Ala Gly Arg Leu Ser Thr Lys Thr Phe
   1               5                  10                  15    
 Cys Thr Gly His Gly Ser Pro Val Asp Ile Cys Thr Ala Lys Pro Arg
              20                  25                  30        
 Asp Ile Pro Met Asn Pro Met Gly Ile Tyr Arg Ser Pro Glu Lys Lys
          35                  40                  45            
 Ala Thr Glu Asp Glu Gly Ser Glu Gln Lys Ile Pro Glu Ala Thr Asn
      50                  55                  60                
 Arg Arg Asp Val Glu Pro Thr Lys Ala Asn Ser Arg Phe Ala Thr Thr
  65                  70                  75                  80
 Phe Tyr Gln His Leu Ala Asp Ser Lys Asn Asp Asn Asp
                  85                  90            



      <210> 2745
      <211> 93
      <212> PRT
      <213> Homo sapiens


      <400> 2745
 Ile Gln Gly Met His Phe Ala Ala Gly Arg Leu Ser Thr Lys Thr Phe
   1               5                  10                  15    
 Cys Thr Gly His Gly Ser Pro Val Asp Ile Cys Thr Ala Lys Pro Arg
              20                  25                  30        
 Asp Ile Pro Met Asn Pro Met Gly Ile Tyr Arg Ser Pro Glu Lys Lys
          35                  40                  45            
 Ala Thr Glu Asp Glu Gly Ser Glu Gln Lys Ile Pro Glu Ala Thr Asn
      50                  55                  60                
 Arg Arg Asp Val Glu Pro Thr Lys Ala Asn Ser Arg Phe Ala Thr Thr
  65                  70                  75                  80
 Phe Tyr Gln His Leu Ala Asp Ser Lys Asn Asp Asn Asp
                  85                  90            



      <210> 2746
      <211> 141
      <212> PRT
      <213> Homo sapiens

      <220>
      <221> misc_feature
      <222> (1)...(141)
      <223> Xaa = any amino acid or symbol as shown in the table 8 as set forth in Example 2


      <400> 2746
 Gly Gly Lys Arg Gly Pro Gly Pro Ile Pro His Pro Pro Ala Arg Gly
   1               5                  10                  15    
 Pro Gln Xaa Gly Pro Gly His Pro Ala Val Gln Val Pro Glu Pro Pro
              20                  25                  30        
 Gly Leu Ser Phe Pro His Phe Arg Gly Gly Phe Pro Ser Ser Gly Gly
          35                  40                  45            
 Cys Gln Arg Gly Glu Gly Arg Lys Glu Arg Arg Pro Ser Trp Thr Gly
      50                  55                  60                
 Pro Ser Trp Met Ala Gln Glu Gly Arg Thr Pro Ala Ala Arg Leu Glu
  65                  70                  75                  80
 Gly Ala Val Leu Pro Gly Ala Pro Gly Pro Glu Ala Pro Gly Thr Gly
                  85                  90                  95    
 Thr Thr Met Ser Ala Pro Thr Trp Pro Glu Pro Pro Gly Gly Arg Gln
             100                 105                 110        
 Val Gln Asp Val Pro Ala Phe Pro Glu Gly Ser Ala Arg Gln Ala Arg
         115                 120                 125            
 Xaa His Glu Glu Xaa Leu His Trp Lys Glu Ile Leu Leu
     130                 135                 140    



      <210> 2747
      <211> 141
      <212> PRT
      <213> Homo sapiens

      <220>
      <221> misc_feature
      <222> (1)...(141)
      <223> Xaa = any amino acid or symbol as shown in the table 8 as set forth in Example 2


      <400> 2747
 Gly Gly Lys Arg Gly Pro Gly Pro Ile Pro His Pro Pro Ala Arg Gly
   1               5                  10                  15    
 Pro Gln Xaa Gly Pro Gly His Pro Ala Val Gln Val Pro Glu Pro Pro
              20                  25                  30        
 Gly Leu Ser Phe Pro His Phe Arg Gly Gly Phe Pro Ser Ser Gly Gly
          35                  40                  45            
 Cys Gln Arg Gly Glu Gly Arg Lys Glu Arg Arg Pro Ser Trp Thr Gly
      50                  55                  60                
 Pro Ser Trp Met Ala Gln Glu Gly Arg Thr Pro Ala Ala Arg Leu Glu
  65                  70                  75                  80
 Gly Ala Val Leu Pro Gly Ala Pro Gly Pro Glu Ala Pro Gly Thr Gly
                  85                  90                  95    
 Thr Thr Met Ser Ala Pro Thr Trp Pro Glu Pro Pro Gly Gly Arg Gln
             100                 105                 110        
 Val Gln Asp Val Pro Ala Phe Pro Glu Gly Ser Ala Arg Gln Ala Arg
         115                 120                 125            
 Xaa His Glu Glu Xaa Leu His Trp Lys Glu Ile Leu Leu
     130                 135                 140    



      <210> 2748
      <211> 306
      <212> PRT
      <213> Homo sapiens


      <400> 2748
 Gln Ala Arg Ser Pro Ser Val Ala Ala Met Ala Ser Pro Gln Leu Cys
   1               5                  10                  15    
 Arg Ala Leu Val Ser Ala Gln Trp Val Ala Glu Ala Leu Arg Ala Pro
              20                  25                  30        
 Arg Ala Gly Gln Pro Leu Gln Leu Leu Asp Ala Ser Trp Tyr Leu Pro
          35                  40                  45            
 Lys Leu Gly Arg Asp Ala Arg Arg Glu Phe Glu Glu Arg His Ile Pro
      50                  55                  60                
 Gly Ala Ala Phe Phe Asp Ile Asp Gln Cys Ser Asp Arg Thr Ser Pro
  65                  70                  75                  80
 Tyr Asp His Met Leu Pro Gly Ala Glu His Phe Ala Glu Tyr Ala Gly
                  85                  90                  95    
 Arg Leu Gly Val Gly Ala Ala Thr His Val Val Ile Tyr Asp Ala Ser
             100                 105                 110        
 Asp Gln Gly Leu Tyr Ser Ala Pro Arg Val Trp Trp Met Phe Arg Ala
         115                 120                 125            
 Phe Gly His His Ala Val Ser Leu Leu Asp Gly Gly Leu Arg His Trp
     130                 135                 140                
 Leu Arg Gln Asn Leu Pro Leu Ser Ser Gly Lys Ser Gln Pro Ala Pro
 145                 150                 155                 160
 Ala Glu Phe Arg Ala Gln Leu Asp Pro Ala Phe Ile Lys Thr Tyr Glu
                 165                 170                 175    
 Asp Ile Lys Glu Asn Leu Glu Ser Arg Arg Phe Gln Val Val Asp Ser
             180                 185                 190        
 Arg Ala Thr Gly Arg Phe Arg Gly Thr Glu Pro Glu Pro Arg Asp Gly
         195                 200                 205            
 Ile Glu Pro Gly His Ile Pro Gly Thr Val Asn Ile Pro Phe Thr Asp
     210                 215                 220                
 Phe Leu Ser Gln Glu Gly Leu Glu Lys Ser Pro Glu Glu Ile Arg His
 225                 230                 235                 240
 Leu Phe Gln Glu Lys Lys Val Asp Leu Ser Lys Pro Leu Val Ala Thr
                 245                 250                 255    
 Cys Gly Ser Gly Val Thr Ala Cys His Val Ala Leu Gly Ala Tyr Leu
             260                 265                 270        
 Cys Gly Lys Pro Asp Val Pro Ile Tyr Asp Gly Ser Trp Val Glu Trp
         275                 280                 285            
 Tyr Met Arg Ala Arg Pro Glu Asp Val Ile Ser Glu Gly Arg Gly Lys
     290                 295                 300                
 Thr His
 305    



      <210> 2749
      <211> 1099
      <212> PRT
      <213> Homo sapiens


      <400> 2749
 Met Ala Gly Ala Leu Pro Pro Ala Ser Leu Pro Pro Cys Ser Leu Ile
   1               5                  10                  15    
 Ser Asp Cys Cys Ala Ser Asn Gln Gly Asp Ser Val Gly Leu Gly Ser
              20                  25                  30        
 Ser Glu Pro Gly Ala Gly Tyr Asn Leu Val Val His Arg Phe Leu Ser
          35                  40                  45            
 Arg Ser Glu Lys Arg Ser Ile Arg Val Gly Val Thr Arg Phe Ser Arg
      50                  55                  60                
 Asp Phe Arg Phe Gly Pro Pro Ile Asn Lys Ile Phe Ala Cys Gly Ala
  65                  70                  75                  80
 Asn Gln Arg Gly Arg Leu Ala Ala Ile Leu Ser Gly Pro Ala Gly Glu
                  85                  90                  95    
 Gly Gln Ser Ala Val Ala Arg Leu Thr Gly Lys Lys Lys Asn His Pro
             100                 105                 110        
 Gly Ala Gln Tyr Ala Thr Arg Leu Ser Pro Arg Val Gly Arg Phe Ile
         115                 120                 125            
 Asn Ala Ala Gly Thr Thr Gly Phe Pro Thr Gly Lys Arg Ala Val Ser
     130                 135                 140                
 Ala Thr Gln Leu Met Ser Asn Thr His Arg Leu Lys Ile Phe Gly Asn
 145                 150                 155                 160
 Asp Pro Gln Leu Pro Arg Gly Gly Phe Val Ile Gly Ala Arg Arg Ser
                 165                 170                 175    
 Asn Gly Ser Arg Lys Arg His Tyr Phe Ala Gly Asn Glu Arg Ala Gln
             180                 185                 190        
 Glu Leu Leu Thr Glu Asp Ala Leu Asp Asp Leu Ile Leu Ser Phe Leu
         195                 200                 205            
 Leu Thr Gly Gln Gln Thr Pro Ala Phe Gly Arg Arg Val Ser Gly Val
     210                 215                 220                
 Ile Glu Ile Ala Asp Gly Ser Arg Arg Arg Lys Ala Ala Ala Leu Thr
 225                 230                 235                 240
 Glu Ser Asp Tyr Arg Val Leu Val Gly Glu Leu Asp Asp Glu Gln Met
                 245                 250                 255    
 Ala Ala Leu Ser Arg Leu Gly Asn Asp Tyr Arg Pro Thr Ser Ala Tyr
             260                 265                 270        
 Glu Arg Gly Gln Arg Tyr Ala Ser Pro Leu Gln Asn Glu Phe Ala Gly
         275                 280                 285            
 Asn Ile Ser Ala Leu Ala Asp Ala Glu Asn Ile Ser Arg Lys Ile Ile
     290                 295                 300                
 Thr Arg Cys Ile Asn Thr Ala Lys Leu Pro Lys Ser Val Val Ala Leu
 305                 310                 315                 320
 Phe Ser His Pro Gly Glu Leu Ser Ala Arg Ser Asp Thr Ser Asn Arg
                 325                 330                 335    
 Ser Ile Gln Leu Ala Ser Gly Trp Cys Pro Pro Arg Met Glu Leu Pro
             340                 345                 350        
 Glu Glu Gly Ala Val Phe Asn Leu Cys Ser Phe Ala Ala Phe Thr Ser
         355                 360                 365            
 Asp Thr Phe Arg Asp Phe Ala Asp Phe Gly Pro Pro Ile Thr Gln Asp
     370                 375                 380                
 Phe Arg Leu Leu Gly Gln Thr Ser Val Asp Arg Leu Leu Gln Leu Ser
 385                 390                 395                 400
 Gln Gly Gln Ala Val Lys Gly Asn Gln Leu Leu Pro Val Ser Leu Val
                 405                 410                 415    
 Lys Arg Lys Thr Thr Leu Ala Pro Asn Thr Gln Thr Ala Ser Pro Arg
             420                 425                 430        
 Ala Leu Ala Asp Ser Leu Met Gln Leu Ala Arg Gln Val Ser Arg Leu
         435                 440                 445            
 Glu Ser Gly Gln Asp Phe Ala Asp Phe Gly Thr Thr Ile Lys Gln Asp
     450                 455                 460                
 Phe Arg Leu Leu Gly Gln Thr Ser Val Asp Arg Leu Leu Gln Leu Ser
 465                 470                 475                 480
 Gln Gly Gln Ala Val Lys Gly Asn Gln Leu Leu Pro Val Ser Leu Val
                 485                 490                 495    
 Lys Arg Lys Thr Thr Leu Ala Pro Asn Thr Gln Thr Ala Ser Pro Arg
             500                 505                 510        
 Ala Leu Ala Asp Ser Leu Met Gln Leu Ala Arg Gln Val Ser Arg Leu
         515                 520                 525            
 Glu Ser Gly Gln Asn Lys Asp Pro Thr Gln Trp Ile Ala Thr Phe Gly
     530                 535                 540                
 Ala Thr Ile Thr Pro Pro Ala Val Lys Arg Asn Val Arg Lys Ile Ile
 545                 550                 555                 560
 Leu His Glu Asn Tyr His Arg Glu Thr Asn Glu Asn Asp Thr Ala Leu
                 565                 570                 575    
 Val Gln Leu Ser Thr Gly Val Glu Phe Ser Asn Ile Val Gln Arg Val
             580                 585                 590        
 Cys Leu Pro Asp Ser Ser Ile Lys Leu Pro Pro Lys Thr Ser Val Phe
         595                 600                 605            
 Val Thr Gly Phe Gly Ser Ile Val Asp Asp Ala Ser Leu Pro Pro Cys
     610                 615                 620                
 Ser Leu Ile Ser Asp Cys Cys Ala Ser Asn Gln Gly Asp Ser Val Gly
 625                 630                 635                 640
 Leu Gly Ser Ser Glu Pro Gly Ala Gly Tyr Asn Leu Val Val His Arg
                 645                 650                 655    
 Phe Leu Ser Arg Ser Glu Lys Arg Ser Ile Arg Val Gly Gly Pro Asp
             660                 665                 670        
 Phe Leu Gly Asp Phe Cys Ser Gln Met Gly Thr Asn Thr Gln Pro Tyr
         675                 680                 685            
 Leu Gly Ala Ile Leu Phe Ile Asn Lys Gly Phe Ala Arg Phe Gly Asn
     690                 695                 700                
 Pro Pro Ser Asn Arg Asp Phe Ser Leu Ala Gly Ala Lys Pro Ala Trp
 705                 710                 715                 720
 Thr Arg Leu Leu His Phe Ser Gln Gly Pro Gly Gly Glu Gly Gln Ser
                 725                 730                 735    
 Ala Val Ala Arg Leu Thr Gly Glu Lys Lys Asn His Pro Gly Ala Gln
             740                 745                 750        
 Tyr Ala Asn Arg Leu Ser Pro Arg Val Gly Arg Phe Ile Asn Ala Ala
         755                 760                 765            
 Gly Thr Thr Gly Phe Leu Thr Gly Lys Arg Ala Val Ser Ala Thr Gln
     770                 775                 780                
 Leu Ile Ile Thr Asn Thr Glu Lys Cys Leu Lys Glu Leu Met Lys Leu
 785                 790                 795                 800
 Lys Thr Lys Ala Arg Glu Leu Arg Glu Glu Cys Arg Ser Leu Arg Ser
                 805                 810                 815    
 Arg Cys Asp Gln Leu Glu Glu Arg Val Ser Ala Met Glu Asp Glu Met
             820                 825                 830        
 Asn Glu Met Lys Arg Glu Gly Lys Phe Arg Glu Lys Arg Ile Lys Arg
         835                 840                 845            
 Asn Glu Gln Ser Leu Gln Glu Ile Trp Asp Tyr Val Lys Arg Pro Asn
     850                 855                 860                
 Leu Arg Leu Ile Gly Val Thr Glu Ser Asp Gly Glu Asn Gly Thr Lys
 865                 870                 875                 880
 Leu Glu Asn Thr Leu Gln Asp Ile Ile Gln Glu Asn Phe Pro Asn Leu
                 885                 890                 895    
 Ala Arg Gln Ser Asn Val Gln Met Ser Arg Ile Phe Arg His Ser Ser
             900                 905                 910        
 Val Gly Gly Arg Phe Ile Lys Ser His Val Ile Lys Leu Arg Leu Gly
         915                 920                 925            
 Asn Asp Tyr Arg Pro Pro Arg Ala Tyr Ala Arg Gly Gln Arg Tyr Ala
     930                 935                 940                
 Thr Arg Leu Gln Asn Glu Phe Ala Ala Asn Ile Ser Ala Leu Ala Asp
 945                 950                 955                 960
 Ala Glu Asn Ile Ser Arg Lys Ile Ile Thr Arg Cys Ile Asn Pro Ala
                 965                 970                 975    
 Lys Leu Pro Lys Ser Val Val Ala Phe Phe Ser His Pro Gly Glu Leu
             980                 985                 990        
 Ser Ala Arg Ser Gly Asp Ala Leu Gln Lys Ala Phe Thr Asp Lys Glu
         995                1000                1005            
 Glu Leu Leu Lys Gln Gln Ala Ser Asn Leu His Glu Gln Lys Lys Ala
    1010                1015                1020                
 Gly Val Ile Phe Glu Ala Glu Glu Val Ile Thr Leu Leu Thr Ser Val
1025                1030                1035                1040
 Leu Lys Thr Ser Ser Ala Ser Arg Thr Ser Leu Ser Ser Pro His Gln
                1045                1050                1055    
 Phe Ala Pro Gly Ala Thr Val Leu Tyr Lys Gly Asp Lys Met Val Leu
            1060                1065                1070        
 Asn Leu Asp Arg Ser Arg Val Pro Thr Glu Cys Ile Glu Lys Ile Glu
        1075                1080                1085            
 Ala Ile Leu Lys Glu Leu Glu Lys Pro Ala Pro
    1090                1095                



      <210> 2750
      <211> 88
      <212> PRT
      <213> Homo sapiens


      <400> 2750
 Pro Leu Thr Thr Val Ser His Leu Cys Pro Leu Ser Leu Arg Val Phe
   1               5                  10                  15    
 Thr Ser His Leu Asp Ile Thr Ala Gly His Ser His Arg Asp Asp Thr
              20                  25                  30        
 Trp Val Pro Ile Pro Ala Leu Pro Leu Lys His Leu Arg Pro Pro Ser
          35                  40                  45            
 Ser Pro Phe Ala Leu Gly Pro Trp Val Ser His Pro Leu Met Arg Trp
      50                  55                  60                
 Val Gln Lys Leu Ser His Leu His Ser Asn Pro Gly Thr Gly Phe Ser
  65                  70                  75                  80
 Met Gly Gly Lys Gln Gln Arg Asn
                  85            



      <210> 2751
      <211> 93
      <212> PRT
      <213> Homo sapiens


      <400> 2751
 Phe His Leu Ser Thr Pro Phe Leu Leu Ser Phe Ile Tyr Leu Thr Cys
   1               5                  10                  15    
 Arg Ala Asn Arg Asn Cys Pro Ile Asp Gln His His Arg Asn Gln Cys
              20                  25                  30        
 Gln Tyr Cys Arg Leu Lys Lys Cys Leu Lys Val Gly Met Arg Arg Glu
          35                  40                  45            
 Gly Glu Tyr Phe Phe Ser Ala Ser Leu Pro Ala Leu Arg Pro Pro Pro
      50                  55                  60                
 Trp Leu Phe Leu Ser Phe Ser Pro Gly Trp Leu Leu Cys Gly Ala Gly
  65                  70                  75                  80
 Ala Pro Val Val Pro Ala Arg Pro Ser Phe Pro Thr Lys
                  85                  90            



      <210> 2752
      <211> 431
      <212> PRT
      <213> Homo sapiens


      <400> 2752
 Asn Asn His Ser Ser Leu Asp Leu Thr Thr Thr Cys Val Ser Ser Ser
   1               5                  10                  15    
 Ala Pro Ser Lys Thr Ser Leu Ile Met Asn Pro His Ala Ser Thr Asn
              20                  25                  30        
 Gly Gln Leu Ser Val His Thr Pro Lys Arg Glu Ser Leu Ser His Glu
          35                  40                  45            
 Glu His Ser His Ser His Pro Leu Tyr Gly His Gly Val Cys Lys Trp
      50                  55                  60                
 Pro Gly Cys Glu Ala Val Cys Glu Asp Phe Gln Ser Phe Leu Lys His
  65                  70                  75                  80
 Leu Asn Ser Glu His Ala Leu Asp Asp Arg Ser Thr Ala Gln Cys Arg
                  85                  90                  95    
 Val Gln Met Gln Val Val Gln Gln Leu Glu Leu Gln Leu Ala Lys Asp
             100                 105                 110        
 Lys Glu Arg Leu Gln Ala Met Met Thr His Leu His Val Lys Ser Thr
         115                 120                 125            
 Glu Pro Lys Ala Ala Pro Gln Pro Leu Asn Leu Val Ser Ser Val Thr
     130                 135                 140                
 Leu Ser Lys Ser Ala Ser Glu Ala Ser Pro Gln Ser Leu Pro His Thr
 145                 150                 155                 160
 Pro Thr Thr Pro Thr Ala Pro Leu Thr Pro Val Thr Gln Gly Pro Ser
                 165                 170                 175    
 Val Ile Thr Thr Thr Ser Met His Thr Trp Gly Thr His Pro Gln Ala
             180                 185                 190        
 Val Leu Arg Gln Ile Gln Arg Ala His Phe Val Ser Arg Phe Ala Gln
         195                 200                 205            
 Asn Gln Glu Phe Tyr Lys Asn Ala Glu Val Arg Pro Pro Phe Thr Tyr
     210                 215                 220                
 Ala Ser Leu Ile Arg Gln Ala Ile Leu Glu Ser Pro Glu Lys Gln Leu
 225                 230                 235                 240
 Thr Leu Asn Glu Ile Tyr Asn Trp Phe Thr Arg Met Phe Ala Tyr Phe
                 245                 250                 255    
 Arg Arg Asn Ala Ala Thr Trp Lys Asn Ala Val Arg His Asn Leu Ser
             260                 265                 270        
 Leu His Lys Cys Phe Val Arg Val Glu Asn Val Lys Gly Ala Val Trp
         275                 280                 285            
 Thr Val Asp Glu Val Glu Phe Gln Lys Arg Arg Pro Gln Lys Ile Ser
     290                 295                 300                
 Gly Asn Pro Ser Leu Ile Lys Asn Met Gln Ser Ser His Ala Tyr Cys
 305                 310                 315                 320
 Thr Pro Leu Asn Ala Ala Leu Gln Ala Ser Met Ala Glu Asn Ser Ile
                 325                 330                 335    
 Pro Leu Tyr Thr Thr Ala Ser Met Gly Asn Pro Thr Leu Gly Asn Leu
             340                 345                 350        
 Ala Ser Ala Ile Arg Glu Glu Leu Asn Gly Ala Met Glu His Thr Asn
         355                 360                 365            
 Ser Asn Glu Ser Asp Ser Ser Pro Gly Arg Ser Pro Met Gln Ala Val
     370                 375                 380                
 His Pro Val His Val Lys Glu Glu Pro Leu Asp Pro Glu Glu Ala Glu
 385                 390                 395                 400
 Gly Pro Leu Ser Leu Val Thr Thr Ala Asn His Ser Pro Asp Phe Asp
                 405                 410                 415    
 His Asp Arg Asp Tyr Glu Asp Glu Pro Val Asn Glu Asp Met Glu
             420                 425                 430    



      <210> 2753
      <211> 124
      <212> PRT
      <213> Homo sapiens


      <400> 2753
 Leu Leu Gln Asp Thr Phe Trp Lys Asn Pro Gln Phe Leu Leu Ser Val
   1               5                  10                  15    
 Trp Arg Pro Glu Glu Gly Arg Arg Ser Leu Arg Pro Cys Ser Val Leu
              20                  25                  30        
 Val Ser Leu Leu Gln Lys Pro Arg His Arg Cys Arg Lys Arg Lys Pro
          35                  40                  45            
 Leu Leu Ala Ile Gly Phe Tyr Leu Tyr Arg Tyr His Asp Asp Gln Arg
      50                  55                  60                
 Arg Leu Pro Pro Glu Phe Phe Gln Arg Asn Thr Pro Leu Ser Gln Pro
  65                  70                  75                  80
 Asp Arg Phe Leu Lys Glu Lys Glu Val Ser Gln Glu Leu Cys Leu Glu
                  85                  90                  95    
 Pro Gly Thr Tyr Leu Ile Val Pro Cys Ile Leu Glu Ala His Gln Lys
             100                 105                 110        
 Ser Glu Phe Val Leu Arg Val Phe Ser Arg Lys Arg
         115                 120                



      <210> 2754
      <211> 157
      <212> PRT
      <213> Homo sapiens


      <400> 2754
 Lys Asn Cys Ser Cys Leu Leu Pro Lys Ile Val Phe Ser Ser Arg Gln
   1               5                  10                  15    
 Asn His Pro Glu Leu Arg Arg Pro Ser Gln Val Asn Ala Ala Glu Gln
              20                  25                  30        
 Arg Glu Glu Phe Leu Asp Gln Val Lys Arg Lys Leu Ala Gln Thr Ser
          35                  40                  45            
 Pro Glu Lys Asp Leu Leu Thr Thr Lys Pro Cys His Cys Lys Asp Ile
      50                  55                  60                
 Leu Lys Leu Val Leu Leu Pro Leu Thr Gln His Cys Leu Val Val Gly
  65                  70                  75                  80
 Glu Thr Thr Cys Ala Phe Tyr Tyr Leu Leu Glu Ala Ala Ala Ala Cys
                  85                  90                  95    
 Leu Asp Leu Ser Asn Asn Tyr Met Val Cys Phe Asn Met Gly Arg Ile
             100                 105                 110        
 Thr Leu Ala Lys Lys Leu Ala Arg Lys Ala Leu Leu Leu Leu Lys Arg
         115                 120                 125            
 Asn Phe Pro Trp Thr Trp Val Gly Gly Leu Phe Gln Thr Phe Leu Gly
     130                 135                 140                
 Lys Glu Trp Ala Phe Met Tyr Pro Glu Pro Pro Pro Asn
 145                 150                 155        



      <210> 2755
      <211> 40
      <212> PRT
      <213> Homo sapiens


      <400> 2755
 Met Gly Thr Val Thr Asn Arg Thr Ala Arg Ala Pro Val Thr Met Leu
   1               5                  10                  15    
 Ser Leu Ile Thr Ala Pro Cys Arg Ala Asp Ala Leu Cys Thr Ser Ala
              20                  25                  30        
 Pro Val Lys Lys Pro Glu Gly Phe
          35                  40



      <210> 2756
      <211> 49
      <212> PRT
      <213> Homo sapiens


      <400> 2756
 Met Tyr Leu Trp Val Val Arg Trp Lys Trp Cys Leu Gln Lys Leu Gly
   1               5                  10                  15    
 Arg Arg Ile Leu Leu His Ser Leu His Asp Val Phe Ile Ala Asn Met
              20                  25                  30        
 Asp Asp Lys Gly Leu Cys Tyr Arg Gly Leu Arg Ala Pro Ser Phe Leu
          35                  40                  45            
 Leu
    



      <210> 2757
      <211> 49
      <212> PRT
      <213> Homo sapiens


      <400> 2757
 Met Tyr Leu Trp Val Val Arg Trp Lys Trp Cys Leu Gln Lys Leu Gly
   1               5                  10                  15    
 Arg Arg Ile Leu Leu His Ser Leu His Asp Val Phe Ile Ala Asn Met
              20                  25                  30        
 Asp Asp Lys Gly Leu Cys Tyr Arg Gly Leu Arg Ala Pro Ser Phe Leu
          35                  40                  45            
 Leu
    



      <210> 2758
      <211> 428
      <212> PRT
      <213> Homo sapiens


      <400> 2758
 Arg Gly Ala Val Phe Pro Gly Pro Glu His Ser Val Pro Glu Glu Ser
   1               5                  10                  15    
 Val Thr Phe Glu Asp Val Ala Val Val Phe Thr Asp Glu Glu Trp Ser
              20                  25                  30        
 Arg Leu Val Pro Ile Gln Arg Asp Leu Tyr Lys Glu Val Met Leu Glu
          35                  40                  45            
 Asn Tyr Asn Ser Ile Val Ser Leu Gly Leu Pro Val Pro Gln Pro Asp
      50                  55                  60                
 Val Ile Phe Gln Leu Lys Arg Gly Asp Lys Pro Trp Met Val Asp Leu
  65                  70                  75                  80
 His Gly Ser Glu Glu Arg Glu Trp Pro Glu Ser Val Ser Leu Asp Trp
                  85                  90                  95    
 Glu Thr Lys Pro Glu Ile His Asp Ala Ser Asp Lys Lys Ser Glu Gly
             100                 105                 110        
 Ser Leu Arg Glu Cys Leu Gly Arg Gln Ser Pro Leu Cys Pro Lys Phe
         115                 120                 125            
 Glu Val His Thr Pro Asn Gly Arg Met Gly Thr Glu Lys Gln Ser Pro
     130                 135                 140                
 Ser Gly Glu Thr Arg Lys Lys Ser Leu Ser Arg Asp Lys Gly Leu Arg
 145                 150                 155                 160
 Arg Arg Ser Ala Leu Ser Arg Glu Ile Leu Thr Lys Glu Arg His Gln
                 165                 170                 175    
 Glu Cys Ser Asp Cys Gly Lys Thr Phe Phe Asp His Ser Ser Leu Thr
             180                 185                 190        
 Arg His Gln Arg Thr His Thr Gly Glu Lys Pro Tyr Asp Cys Arg Glu
         195                 200                 205            
 Cys Gly Lys Ala Phe Ser His Arg Ser Ser Leu Ser Arg His Leu Met
     210                 215                 220                
 Ser His Thr Gly Glu Ser Pro Tyr Glu Cys Ser Val Cys Ser Lys Ala
 225                 230                 235                 240
 Phe Phe Asp Arg Ser Ser Leu Thr Val His Gln Arg Ile His Thr Gly
                 245                 250                 255    
 Glu Lys Pro Phe Gln Cys Asn Glu Cys Gly Lys Ala Phe Phe Asp Arg
             260                 265                 270        
 Ser Ser Leu Thr Arg His Gln Arg Ile His Thr Gly Glu Ser Pro Tyr
         275                 280                 285            
 Glu Cys His Gln Cys Gly Lys Ala Phe Ser Gln Lys Ser Ile Leu Thr
     290                 295                 300                
 Arg His Gln Leu Ile His Thr Gly Arg Lys Pro Tyr Glu Cys Asn Glu
 305                 310                 315                 320
 Cys Gly Lys Ala Phe Tyr Gly Val Ser Ser Leu Asn Arg His Gln Lys
                 325                 330                 335    
 Ala His Ala Gly Asp Pro Arg Tyr Gln Cys Asn Glu Cys Gly Lys Ala
             340                 345                 350        
 Phe Phe Asp Arg Ser Ser Leu Thr Gln His Gln Lys Ile His Thr Gly
         355                 360                 365            
 Asp Lys Pro Tyr Glu Cys Ser Glu Cys Gly Lys Ala Phe Ser Gln Arg
     370                 375                 380                
 Cys Arg Leu Thr Arg His Gln Arg Val His Thr Gly Glu Lys Pro Phe
 385                 390                 395                 400
 Glu Cys Thr Val Cys Gly Lys Val Phe Ser Ser Lys Ser Ser Val Ile
                 405                 410                 415    
 Gln His Gln Arg Arg Tyr Ala Lys Gln Gly Ile Asp
             420                 425            



      <210> 2759
      <211> 338
      <212> PRT
      <213> Homo sapiens


      <400> 2759
 Lys Val Glu Arg Ile Val Lys Ala Asn Asp Arg Glu Tyr Asn Glu Lys
   1               5                  10                  15    
 Phe Gln Tyr Ala His Ser Cys Thr Ala His Met Met Gln Ile Leu Thr
              20                  25                  30        
 Tyr Gly Ala Asp Asp Gln Met His Gln Leu Lys Ser Thr Asp Asp Asp
          35                  40                  45            
 Lys Gln Cys Asp Thr Leu Glu Leu Val Met Glu Ser Thr Ser Asn Leu
      50                  55                  60                
 His Leu Leu Trp Val Ser Gly Ser Ala Phe Val Glu Glu His Cys Arg
  65                  70                  75                  80
 Leu Ser Ile Ala Pro Ile Leu Glu Ser Cys Gly Leu Cys Thr Arg Gln
                  85                  90                  95    
 Gln Ser Ala Asp Thr Glu Glu Leu Pro Gly Val Leu Pro Gly Ile Ser
             100                 105                 110        
 Glu Lys Val Ala Ala Gly Leu Lys Cys Arg Leu Glu Glu Arg Ala Arg
         115                 120                 125            
 Ala Asp Tyr Ser Glu Ser Arg Arg Asp Asn Cys Phe Ala Met Asn Trp
     130                 135                 140                
 Gly Ser Thr Val Val Lys Arg Val Gly Ser Gly Ala Glu Cys Leu Leu
 145                 150                 155                 160
 Leu Asp Pro Asn Pro Gly Ser Tyr Asn His His Leu Gln Ala Val Ser
                 165                 170                 175    
 Thr Arg Asp Asn Arg Ile His Thr Ser Lys Tyr Asn Ile Leu Thr Phe
             180                 185                 190        
 Leu Pro Ile Asn Leu Phe Glu Gln Phe Gln Arg Val Ala Asn Ala Tyr
         195                 200                 205            
 Phe Leu Cys Leu Leu Ile Leu Gln Leu Ile Pro Glu Ile Ser Ser Leu
     210                 215                 220                
 Thr Trp Phe Thr Thr Ile Val Pro Leu Val Leu Val Ile Thr Met Thr
 225                 230                 235                 240
 Ala Val Lys Asp Ala Thr Asp Asp Tyr Leu Met Leu Glu Cys Ala Phe
                 245                 250                 255    
 Thr Phe Cys Asp Val Met Cys Gln Phe Ile Asn Trp Thr Pro Ser Pro
             260                 265                 270        
 Val Arg Val Leu Ala Lys His Arg Gly Tyr Pro Glu Ile Gly Trp Ile
         275                 280                 285            
 Gly Glu Phe Asn Asn Asp Gly Ile Ile His Lys Gly Cys Gly Gln Gly
     290                 295                 300                
 Lys Ala Ala Met Ala Ala Thr Trp Leu Ala Ile Leu Leu Asp Leu Lys
 305                 310                 315                 320
 Arg Gln Arg Asn Glu Gly Val Thr Arg Pro Gly Asp Val Val Glu Ala
                 325                 330                 335    
 Cys Leu
        



      <210> 2760
      <211> 64
      <212> PRT
      <213> Homo sapiens


      <400> 2760
 Asn Ser Leu Arg Phe Phe Phe Phe Phe Leu Gln Phe Ser Ile Phe Ile
   1               5                  10                  15    
 Phe Leu Ser Ser Ser Thr Met Val Ser Val Ser Val Phe Tyr Met Trp
              20                  25                  30        
 Pro Lys Lys Ile Leu Pro Met Arg Ser Arg Glu Ala Lys Ile Leu Asp
          35                  40                  45            
 Thr Pro Cys Leu Gly Glu His Cys Phe Val Tyr Leu Val Ser Ser Ser
      50                  55                  60                





      <210> 2761
      <211> 209
      <212> PRT
      <213> Homo sapiens


      <400> 2761
 Asn Leu His Phe Leu Tyr Phe Val Val Ile Gly Leu Arg Ser Glu Asn
   1               5                  10                  15    
 Cys Ser Leu Arg Phe Phe Arg Leu Ile Pro Val Pro Met Val Gly Phe
              20                  25                  30        
 Lys Glu Leu Leu Arg Arg Leu Lys Val Gln Asp Gln Met Thr Lys Gln
          35                  40                  45            
 His Gln Thr Arg Leu Asp Ile Ile Ser Glu Asp Ile Ser Glu Leu Gln
      50                  55                  60                
 Lys Asn Gln Thr Thr Ser Val Ala Lys Ile Ala Gln Tyr Lys Arg Lys
  65                  70                  75                  80
 Leu Met Asp Leu Ser His Arg Thr Leu Gln Val Leu Ile Lys Gln Glu
                  85                  90                  95    
 Ile Gln Arg Lys Ser Gly Tyr Ala Ile Gln Ala Asp Glu Glu Gln Leu
             100                 105                 110        
 Arg Val Gln Leu Asp Thr Ile Gln Gly Glu Leu Asn Ala Pro Thr Gln
         115                 120                 125            
 Phe Lys Gly Arg Leu Asn Glu Leu Met Ser Gln Ile Arg Met Gln Asn
     130                 135                 140                
 His Phe Gly Ala Val Arg Ser Glu Glu Arg Tyr Tyr Ile Asp Ala Asp
 145                 150                 155                 160
 Leu Leu Arg Glu Ile Lys Gln His Leu Lys Gln Gln Gln Glu Gly Leu
                 165                 170                 175    
 Ser His Leu Ile Ser Ile Ile Lys Asp Asp Leu Glu Asp Ile Lys Leu
             180                 185                 190        
 Val Glu His Gly Leu Asn Glu Thr Ile His Ile Arg Gly Gly Val Phe
         195                 200                 205            
 Ser
    



      <210> 2762
      <211> 112
      <212> PRT
      <213> Homo sapiens


      <400> 2762
 Met Ala Leu Gly Val Pro Ile Ser Val Tyr Leu Leu Phe Asn Ala Met
   1               5                  10                  15    
 Thr Ala Leu Thr Glu Glu Ala Ala Val Thr Val Thr Pro Pro Ile Thr
              20                  25                  30        
 Ala Gln Gln Gly Asn Trp Thr Val Asn Lys Thr Glu Ala Asp Asn Ile
          35                  40                  45            
 Glu Gly Pro Ile Ala Leu Lys Phe Ser His Leu Cys Leu Glu Asp His
      50                  55                  60                
 Asn Ser Tyr Cys Ile Asn Gly Ala Cys Ala Phe His His Glu Leu Glu
  65                  70                  75                  80
 Lys Ala Ile Cys Arg Cys Phe Thr Gly Tyr Thr Gly Glu Arg Cys Leu
                  85                  90                  95    
 Lys Leu Lys Ser Pro Tyr Asn Val Cys Ser Gly Glu Arg Arg Pro Leu
             100                 105                 110        





      <210> 2763
      <211> 478
      <212> PRT
      <213> Homo sapiens


      <400> 2763
 Gln Arg Pro Ala Ser Gln Leu Leu Ala Pro Phe Ala Ala Glu Ala Leu
   1               5                  10                  15    
 Pro Gly Ala Pro Arg Ala Ala Met Ala Gln His Phe Ser Leu Ala Ala
              20                  25                  30        
 Cys Asp Val Val Gly Phe Asp Leu Asp His Thr Leu Cys Arg Tyr Asn
          35                  40                  45            
 Leu Pro Glu Ser Ala Pro Leu Ile Tyr Asn Ser Phe Ala Gln Phe Leu
      50                  55                  60                
 Val Lys Glu Lys Gly Tyr Asp Lys Glu Leu Leu Asn Val Thr Pro Glu
  65                  70                  75                  80
 Asp Trp Asp Phe Cys Cys Lys Gly Leu Ala Leu Asp Leu Glu Asp Gly
                  85                  90                  95    
 Asn Phe Leu Lys Leu Ala Asn Asn Gly Thr Val Leu Arg Ala Ser His
             100                 105                 110        
 Gly Thr Lys Met Met Thr Pro Glu Val Leu Ala Glu Ala Tyr Gly Lys
         115                 120                 125            
 Lys Glu Trp Lys His Phe Leu Ser Asp Thr Gly Met Ala Cys Arg Ser
     130                 135                 140                
 Gly Lys Tyr Tyr Phe Tyr Asp Asn Tyr Phe Asp Leu Pro Gly Ala Leu
 145                 150                 155                 160
 Leu Cys Ala Arg Val Val Asp Tyr Leu Thr Lys Leu Asn Asn Gly Gln
                 165                 170                 175    
 Lys Thr Phe Asp Phe Trp Lys Asp Ile Val Ala Ala Ile Gln His Asn
             180                 185                 190        
 Tyr Lys Met Ser Ala Phe Lys Glu Asn Cys Gly Ile Tyr Phe Pro Glu
         195                 200                 205            
 Ile Lys Arg Asp Pro Gly Arg Tyr Leu His Ser Cys Pro Glu Ser Val
     210                 215                 220                
 Lys Lys Trp Leu Arg Gln Leu Lys Asn Ala Gly Lys Ile Leu Leu Leu
 225                 230                 235                 240
 Ile Thr Ser Ser His Ser Asp Tyr Cys Arg Leu Leu Cys Ala Tyr Ile
                 245                 250                 255    
 Leu Gly Asn Asp Phe Thr Asp Leu Phe Asp Ile Val Ile Thr Asn Ala
             260                 265                 270        
 Leu Lys Pro Gly Phe Phe Ser His Leu Pro Ser Gln Arg Pro Phe Arg
         275                 280                 285            
 Thr Leu Glu Asn Asp Glu Glu Gln Glu Ala Leu Pro Ser Leu Asp Lys
     290                 295                 300                
 Pro Gly Trp Tyr Ser Gln Gly Asn Ala Val His Leu Tyr Glu Leu Leu
 305                 310                 315                 320
 Lys Lys Met Thr Gly Lys Pro Glu Pro Lys Val Val Tyr Phe Gly Asp
                 325                 330                 335    
 Ser Met His Ser Asp Ile Phe Pro Ala Arg His Tyr Ser Asn Trp Glu
             340                 345                 350        
 Thr Val Leu Ile Leu Glu Glu Leu Arg Gly Asp Glu Gly Thr Arg Ser
         355                 360                 365            
 Gln Arg Pro Glu Glu Ser Glu Pro Leu Glu Lys Lys Gly Lys Tyr Glu
     370                 375                 380                
 Gly Pro Lys Ala Lys Pro Leu Asn Thr Ser Ser Lys Lys Trp Gly Ser
 385                 390                 395                 400
 Phe Phe Ile Asp Ser Val Leu Gly Leu Glu Asn Thr Glu Asp Ser Leu
                 405                 410                 415    
 Val Tyr Thr Trp Ser Cys Lys Arg Ile Ser Thr Tyr Ser Thr Ile Ala
             420                 425                 430        
 Ile Pro Ser Ile Glu Ala Ile Ala Glu Leu Pro Leu Asp Tyr Lys Phe
         435                 440                 445            
 Thr Arg Phe Ser Ser Ser Asn Ser Lys Thr Ala Gly Tyr Tyr Pro Asn
     450                 455                 460                
 Pro Pro Leu Val Leu Ser Ser Asp Glu Thr Leu Ile Ser Lys
 465                 470                 475            



      <210> 2764
      <211> 181
      <212> PRT
      <213> Homo sapiens


      <400> 2764
 Phe Val Gly His Cys Val Asn Thr Glu Gly Gly Phe Val Cys Glu Arg
   1               5                  10                  15    
 Gly Pro Gly Met Arg Val Ser Ala Asp Arg His Ser Cys Gln Asp Thr
              20                  25                  30        
 Asp Glu Cys Leu Gly Thr Pro Cys Gln Gln Arg Cys Lys Asn Ser Ile
          35                  40                  45            
 Gly Ser Tyr Lys Cys Ser Cys Arg Thr Gly Phe His Leu His Gly Asn
      50                  55                  60                
 Arg His Ser Cys Val Asp Tyr Thr Pro Arg Ile Pro Leu Cys Ser Pro
  65                  70                  75                  80
 Ile Phe Leu Ala Ala Phe Ala Pro Leu Asp Val Asn Glu Cys Arg Arg
                  85                  90                  95    
 Pro Leu Glu Arg Arg Val Cys His His Ser Cys His Asn Thr Gly Gly
             100                 105                 110        
 Ser Phe Leu Cys Thr Cys Arg Pro Gly Phe Arg Leu Arg Ala Asp Arg
         115                 120                 125            
 Val Ser Cys Glu Asp Phe Pro Glu Ser Arg Ala Gly Pro Ile Cys His
     130                 135                 140                
 Pro Ala Thr Pro Val Thr Pro Val Gln Glu Cys Tyr Cys Cys Leu Leu
 145                 150                 155                 160
 Arg Pro His Gly Leu Pro Cys Ala Gln Asp Ile Asp Leu Leu Leu Gly
                 165                 170                 175    
 Leu Gln Gly His Gln
             180    



      <210> 2765
      <211> 145
      <212> PRT
      <213> Homo sapiens


      <400> 2765
 Leu Ser Ala Ala Arg Lys Pro Thr Tyr His Gly Thr Ile Leu Leu Ser
   1               5                  10                  15    
 Leu Glu Leu Cys His Ser Gly Leu Cys Lys Phe Pro Lys Val Gly Gly
              20                  25                  30        
 Lys Met Thr Met Ser Lys Glu Ala Val Thr Phe Lys Asp Val Ala Val
          35                  40                  45            
 Val Phe Thr Glu Glu Glu Leu Gly Leu Leu Asp Pro Ala Gln Arg Lys
      50                  55                  60                
 Leu Tyr Arg Asp Val Met Leu Glu Asn Phe Arg Asn Leu Leu Ser Val
  65                  70                  75                  80
 Gly His Gln Pro Phe His Arg Asp Thr Phe His Phe Leu Arg Glu Glu
                  85                  90                  95    
 Lys Phe Trp Met Met Gly Thr Ala Thr Gln Arg Glu Gly Asn Ser Gly
             100                 105                 110        
 Gly Lys Ile Gln Thr Glu Leu Glu Ser Val Pro Glu Ala Gly Ala His
         115                 120                 125            
 Glu Glu Trp Ser Cys Gln Gln Ile Trp Glu Gln Ile Ala Lys Asp Leu
     130                 135                 140                
 Thr
 145



      <210> 2766
      <211> 159
      <212> PRT
      <213> Homo sapiens


      <400> 2766
 Ser Asp Lys Ala Phe Ser Gln Ser Ser Tyr Leu Ile Gln His Gln Arg
   1               5                  10                  15    
 Phe His Ile Gly Val Lys Pro Phe Glu Cys Ser Glu Cys Gly Lys Ala
              20                  25                  30        
 Phe Ser Lys Asn Ser Ser Leu Thr Gln His Gln Arg Ile His Thr Gly
          35                  40                  45            
 Glu Lys Pro Tyr Glu Cys Tyr Ile Cys Lys Lys His Phe Thr Gly Arg
      50                  55                  60                
 Ser Ser Leu Ile Val His Gln Ile Val His Thr Gly Glu Lys Pro Tyr
  65                  70                  75                  80
 Val Cys Gly Glu Cys Gly Lys Ala Phe Ser Gln Ser Ala Tyr Leu Ile
                  85                  90                  95    
 Glu His Gln Arg Ile His Thr Gly Glu Lys Pro Tyr Arg Cys Gly Gln
             100                 105                 110        
 Cys Gly Lys Ser Phe Ile Lys Asn Ser Ser Leu Thr Val His Gln Arg
         115                 120                 125            
 Ile His Thr Gly Glu Lys Pro Tyr Arg Cys Gly Glu Cys Gly Lys Thr
     130                 135                 140                
 Phe Ser Arg Asn Thr Asn Leu Thr Arg His Leu Arg Ile His Thr
 145                 150                 155                



      <210> 2767
      <211> 60
      <212> PRT
      <213> Homo sapiens


      <400> 2767
 Met Pro Gln Trp Leu Ala Leu Gln Arg Gln Gln Ala Leu Leu Thr Leu
   1               5                  10                  15    
 Leu Ser Gly Ala Gly Thr Trp Ala Gly Met Arg Pro Pro Ser Gln Cys
              20                  25                  30        
 Trp Pro Gln Gly Pro Ser Thr Gly Asn Gln Ser Leu Ser His Gly Arg
          35                  40                  45            
 Gly Glu Leu Leu Thr His Ala Val Gly Val Cys Ile
      50                  55                  60



      <210> 2768
      <211> 328
      <212> PRT
      <213> Homo sapiens

      <220>
      <221> misc_feature
      <222> (1)...(328)
      <223> Xaa = any amino acid or symbol as shown in the table 8 as set forth in Example 2


      <400> 2768
 Leu Gln Gly Asp Thr Trp His Leu Ser Phe Leu Ser His Phe Ser Arg
   1               5                  10                  15    
 Leu His Gly Gly Val Pro Gly Arg Gly Leu Leu Glu Gly Asn Leu Leu
              20                  25                  30        
 Gln Pro Gln Ala Pro Gly His Asp Met Thr Ser Ile Pro Phe Pro Gly
          35                  40                  45            
 Asp Arg Leu Leu Gln Val Asp Gly Val Ile Leu Cys Gly Leu Thr His
      50                  55                  60                
 Lys Gln Ala Val Gln Cys Leu Lys Gly Pro Gly Gln Val Ala Arg Leu
  65                  70                  75                  80
 Val Leu Glu Arg Arg Val Pro Arg Ser Thr Gln Gln Cys Pro Ser Ala
                  85                  90                  95    
 Asn Asp Ser Met Gly Asp Glu Arg Thr Ala Val Ser Leu Val Thr Ala
             100                 105                 110        
 Leu Pro Gly Arg Pro Ser Ser Cys Val Ser Val Thr Asp Gly Pro Lys
         115                 120                 125            
 Phe Xaa Ser Ser Asn Xaa Lys Arg Ile Ala Asn Gly Leu Gly Phe Ser
     130                 135                 140                
 Phe Val Gln Met Glu Lys Glu Ser Cys Ser His Leu Lys Ser Asp Leu
 145                 150                 155                 160
 Val Arg Ile Lys Arg Leu Phe Pro Gly His Pro Ala Glu Glu Asn Gly
                 165                 170                 175    
 Ala Ile Ala Ala Gly Asp Ile Ile Leu Gly Arg Glu Trp Glu Gly Pro
             180                 185                 190        
 Arg Lys Ala Ser Ser Ser Arg Cys Arg Gly Ser Trp Ala Met Gln Leu
         195                 200                 205            
 Ser Val Gln Ala Gly Pro Ser Phe Ala Ser Tyr Tyr Pro Ala Ala Val
     210                 215                 220                
 Glu Val Leu His Leu Leu Arg Gly Ala Pro Gln Glu Val Thr Leu Leu
 225                 230                 235                 240
 Leu Cys Arg Pro Pro Pro Gly Ala Leu Pro Glu Leu Glu Gln Glu Trp
                 245                 250                 255    
 Gln Thr Pro Glu Leu Ser Ala Asp Lys Glu Phe Thr Arg Ala Thr Cys
             260                 265                 270        
 Thr Asp Ser Cys Thr Ser Pro Ile Leu Gly Ser Arg Gly Gln Leu Gly
         275                 280                 285            
 Gly Thr Val Pro Pro Gln Met Gln Gly Lys Ala Trp Gly Leu Arg Pro
     290                 295                 300                
 Glu Ser Ser Gln Lys Ala Ile Arg Glu Gly Thr Met Gly Ala Lys Thr
 305                 310                 315                 320
 Glu Arg Asp Leu Gly Pro Val Pro
                 325            



      <210> 2769
      <211> 475
      <212> PRT
      <213> Homo sapiens

      <220>
      <221> misc_feature
      <222> (1)...(475)
      <223> Xaa = any amino acid or symbol as shown in the table 8 as set forth in Example 2


      <400> 2769
 Val Arg Arg Ser His Trp Cys Phe Ala Ser Phe Ser Pro Ser Ile Ser
   1               5                  10                  15    
 Leu Ser Val Ser Arg Ala Ala Val Gln Val Gly Gly Met Asp Cys Lys
              20                  25                  30        
 Ser Gln Lys Ser Gln Ala Thr Ser Thr Leu Gln Val Ala Thr Pro His
          35                  40                  45            
 Pro Ala Lys His Arg Phe Phe Leu Pro Thr Phe Pro Ser Ala Pro Thr
      50                  55                  60                
 Val His Thr Ile Pro Tyr Ala Cys Pro Phe Gly Lys Leu Ala Ser Arg
  65                  70                  75                  80
 Thr Ala Ser Phe Leu Glu Arg Gln Gln Glu Ala Asp Gly His Ser Ser
                  85                  90                  95    
 Thr Leu Ser Cys Leu Trp Ala Asp Arg Gln Gln Gln Leu Tyr Ile Phe
             100                 105                 110        
 Lys Gly Ser His Phe Trp Glu Val Ala Ala Asp Gly Asn Val Ser Glu
         115                 120                 125            
 Pro Arg Pro Leu Gln Glu Arg Trp Val Gly Leu Pro Pro Asn Ile Glu
     130                 135                 140                
 Ala Ala Ala Val Ser Leu Asn Asp Gly Asp Phe Tyr Phe Phe Lys Gly
 145                 150                 155                 160
 Gly Arg Cys Trp Arg Phe Arg Gly Pro Lys Pro Val Trp Gly Leu Pro
                 165                 170                 175    
 Gln Leu Cys Arg Ala Gly Gly Leu Pro Arg His Pro Asp Ala Ala Leu
             180                 185                 190        
 Phe Phe Pro Pro Leu Arg Arg Leu Ile Leu Phe Lys Gly Ala Arg Tyr
         195                 200                 205            
 Tyr Val Leu Ala Arg Gly Gly Leu Xaa Lys Pro Glu Ile Pro Ser His
     210                 215                 220                
 Lys His Ala Ala Gly Ser Asn Pro Thr Pro Ser Lys Thr Pro Leu Leu
 225                 230                 235                 240
 Pro Ala His Phe Pro Leu Cys Ala Asn Cys Thr His His Thr His Ala
                 245                 250                 255    
 Cys Pro Phe Gly Lys Leu Ala Ser Arg Thr Ala Ser Phe Leu Glu Arg
             260                 265                 270        
 Gln Gln Glu Ala Asp Gly His Ser Ser Thr Leu Ser Cys Leu Trp Ala
         275                 280                 285            
 Asp Arg Gln Gln Gln Leu Tyr Ile Phe Lys Gly Ser His Phe Trp Glu
     290                 295                 300                
 Val Ala Ala Asp Gly Asn Val Ser Glu Pro Arg Pro Leu Gln Glu Arg
 305                 310                 315                 320
 Trp Val Gly Leu Pro Pro Asn Ile Glu Ala Ala Ala Val Ser Leu Asn
                 325                 330                 335    
 Asp Gly Asp Phe Tyr Phe Phe Lys Gly Gly Arg Cys Trp Arg Phe Arg
             340                 345                 350        
 Gly Pro Lys Pro Val Trp Gly Leu Pro Gln Leu Cys Arg Ala Gly Gly
         355                 360                 365            
 Leu Pro Arg His Pro Asp Ala Ala Leu Phe Phe Pro Pro Leu Arg Arg
     370                 375                 380                
 Leu Ile Leu Phe Lys Gly Ala Arg Tyr Tyr Val Leu Ala Arg Gly Gly
 385                 390                 395                 400
 Leu Gln Val Glu Pro Tyr Tyr Pro Arg Ser Leu Gln Asp Trp Gly Gly
                 405                 410                 415    
 Ile Pro Glu Glu Val Ser Gly Ala Leu Pro Arg Pro Asp Gly Ser Ile
             420                 425                 430        
 Ile Phe Phe Arg Asp Asp Arg Tyr Trp Arg Leu Asp Gln Ala Lys Leu
         435                 440                 445            
 Gln Ala Thr Thr Ser Gly Arg Trp Ala Thr Glu Leu Pro Trp Met Gly
     450                 455                 460                
 Cys Trp His Ala Asn Ser Gly Ser Ala Leu Phe
 465                 470                 475



      <210> 2770
      <211> 157
      <212> PRT
      <213> Homo sapiens


      <400> 2770
 Thr Gly Pro Thr Ile Lys Asn Met Asp Gly Thr Phe Asn Val Thr Ser
   1               5                  10                  15    
 Cys Leu Lys Leu Asn Ser Ser Gln Glu Asp Pro Gly Thr Val Tyr Gln
              20                  25                  30        
 Cys Val Val Arg His Ala Ser Leu His Thr Pro Leu Arg Ser Asn Phe
          35                  40                  45            
 Thr Leu Thr Ala Ala Arg His Ser Leu Ser Glu Thr Glu Lys Thr Asp
      50                  55                  60                
 Asn Phe Ser Ile His Trp Trp Pro Ile Ser Phe Ile Gly Val Gly Leu
  65                  70                  75                  80
 Val Leu Leu Ile Val Leu Ile Pro Trp Lys Lys Ile Cys Asn Lys Ser
                  85                  90                  95    
 Ser Ser Ala Tyr Thr Pro Leu Lys Cys Ile Leu Lys His Trp Asn Ser
             100                 105                 110        
 Phe Asp Thr Gln Thr Leu Lys Lys Glu His Leu Ile Phe Phe Cys Thr
         115                 120                 125            
 Arg Ala Trp Pro Ser Tyr Gln Leu Gln Asp Gly Glu Ala Trp Pro Pro
     130                 135                 140                
 Glu Gly Ser Val Asn Ile Asn Thr Tyr Ser Thr Thr Val
 145                 150                 155        



      <210> 2771
      <211> 160
      <212> PRT
      <213> Homo sapiens


      <400> 2771
 Lys Leu Lys Glu Asp Cys Asn Asn Thr Asp Asn Lys Glu Arg Lys Ser
   1               5                  10                  15    
 Phe Gln Lys Glu Leu Gly Met Ala Leu Leu Lys Met Asp Cys Gln Gly
              20                  25                  30        
 Leu Val Val Arg Leu Ile Gln Asp Phe Val Leu Leu Thr Thr Ala Val
          35                  40                  45            
 Glu Val Ala Gln Arg Trp Arg Glu Leu Ala Glu Lys Leu Ala Lys Val
      50                  55                  60                
 Ser Lys Gln Gln Met Asp Ala Tyr Glu Ser Pro His Arg Asp Arg Asn
  65                  70                  75                  80
 Gly Val Val Asp Ser Glu Ala Met Trp Lys Pro Ala Tyr Asp Phe Leu
                  85                  90                  95    
 Leu Thr Trp Ser His Gln Ile Gly Asp Ser Tyr Arg Asp Val Ile Gln
             100                 105                 110        
 Glu Leu His Leu Gly Leu Asp Lys Met Lys Asn Pro Ile Thr Lys Arg
         115                 120                 125            
 Trp Lys His Leu Thr Gly Thr Leu Ile Leu Val Asn Ser Leu Asp Val
     130                 135                 140                
 Leu Arg Ala Ala Ala Phe Ser Pro Ala Asp Gln Asp Asp Phe Val Ile
 145                 150                 155                 160





      <210> 2772
      <211> 301
      <212> PRT
      <213> Homo sapiens


      <400> 2772
 Ser Cys Ser Asp Ala Ala Val Arg Arg Ile Ser Ser Ala His Ser Ala
   1               5                  10                  15    
 Pro Gln Val Val Leu Val Cys Arg Val Met Thr Ser Phe Arg Leu Ala
              20                  25                  30        
 Leu Ile Gln Leu Gln Ile Ser Ser Ile Lys Ser Asp Asn Val Thr Arg
          35                  40                  45            
 Ala Cys Ser Phe Ile Arg Glu Ala Ala Thr Gln Gly Ala Lys Ile Val
      50                  55                  60                
 Ser Leu Pro Glu Cys Phe Asn Ser Pro Tyr Gly Ala Lys Tyr Phe Pro
  65                  70                  75                  80
 Glu Tyr Ala Glu Lys Ile Pro Gly Glu Ser Thr Gln Lys Leu Ser Glu
                  85                  90                  95    
 Val Ala Lys Glu Cys Ser Ile Tyr Leu Ile Gly Gly Ser Ile Pro Glu
             100                 105                 110        
 Glu Asp Ala Gly Lys Leu Tyr Asn Thr Cys Ala Val Phe Gly Pro Asp
         115                 120                 125            
 Gly Thr Leu Leu Ala Lys Tyr Arg Lys Ile His Leu Phe Asp Ile Asp
     130                 135                 140                
 Val Pro Gly Lys Ile Thr Phe Gln Glu Ser Lys Thr Leu Ser Pro Gly
 145                 150                 155                 160
 Asp Ser Phe Ser Thr Phe Asp Thr Pro Tyr Cys Arg Val Gly Leu Gly
                 165                 170                 175    
 Ile Cys Tyr Asp Met Arg Phe Ala Glu Leu Ala Gln Ile Tyr Ala Gln
             180                 185                 190        
 Arg Gly Cys Gln Leu Leu Val Tyr Pro Gly Ala Phe Asn Leu Thr Thr
         195                 200                 205            
 Gly Pro Ala His Trp Glu Leu Leu Gln Arg Ser Arg Ala Val Asp Asn
     210                 215                 220                
 Gln Val Tyr Val Ala Thr Ala Ser Pro Ala Arg Asp Asp Lys Ala Ser
 225                 230                 235                 240
 Tyr Val Ala Trp Gly His Ser Thr Val Val Asn Pro Trp Gly Glu Val
                 245                 250                 255    
 Leu Ala Lys Ala Gly Thr Glu Glu Ala Ile Val Tyr Ser Asp Ile Asp
             260                 265                 270        
 Leu Lys Lys Leu Ala Glu Ile Arg Gln Gln Ile Pro Val Phe Arg Gln
         275                 280                 285            
 Lys Arg Ser Asp Leu Tyr Ala Val Glu Met Lys Lys Pro
     290                 295                 300    



      <210> 2773
      <211> 201
      <212> PRT
      <213> Homo sapiens


      <400> 2773
 His Arg Arg Trp Leu Pro Gly Leu Ser Met Ser Pro Arg Arg Thr Leu
   1               5                  10                  15    
 Pro Arg Pro Leu Ser Leu Cys Leu Ser Leu Cys Leu Cys Leu Cys Leu
              20                  25                  30        
 Ala Ala Ala Leu Gly Ser Ala Gln Ser Gly Ser Cys Arg Asp Lys Lys
          35                  40                  45            
 Asn Cys Lys Val Val Phe Ser Gln Gln Glu Leu Arg Lys Arg Leu Thr
      50                  55                  60                
 Pro Leu Gln Tyr His Val Thr Gln Glu Lys Gly Thr Glu Ser Ala Phe
  65                  70                  75                  80
 Glu Gly Glu Tyr Thr His His Lys Asp Pro Gly Ile Tyr Lys Cys Val
                  85                  90                  95    
 Val Cys Gly Thr Pro Leu Phe Lys Ser Glu Thr Lys Phe Asp Ser Gly
             100                 105                 110        
 Ser Gly Trp Pro Ser Phe His Asp Val Ile Asn Ser Glu Ala Ile Thr
         115                 120                 125            
 Phe Thr Asp Asp Phe Ser Tyr Gly Met His Arg Val Glu Thr Ser Cys
     130                 135                 140                
 Ser Gln Cys Gly Ala His Leu Gly His Ile Phe Asp Asp Gly Pro Arg
 145                 150                 155                 160
 Pro Thr Gly Lys Arg Tyr Cys Ile Asn Ser Ala Ala Leu Ser Phe Thr
                 165                 170                 175    
 Pro Ala Asp Ser Ser Gly Thr Ala Glu Gly Gly Ser Gly Val Ala Ser
             180                 185                 190        
 Pro Ala Gln Ala Asp Lys Ala Glu Leu
         195                 200    



      <210> 2774
      <211> 44
      <212> PRT
      <213> Homo sapiens


      <400> 2774
 Ile Gln Ser Gly Leu Ser Leu Cys Phe Ala Asp Leu Ser Glu Thr Pro
   1               5                  10                  15    
 Glu Gly Arg Ala Gly Val Pro Gly Cys Pro His Ser Cys Asp Gly Val
              20                  25                  30        
 Ala Ser Gly Arg Pro Cys Ser Pro Ser Ser Ala Gly
          35                  40                



      <210> 2775
      <211> 77
      <212> PRT
      <213> Homo sapiens


      <400> 2775
 Gln Ser Leu Leu Gly Leu Pro Arg His Met Gly Gln Arg Asp Gln Glu
   1               5                  10                  15    
 Phe Gln Leu Arg Lys Leu His Glu Gly Lys Cys Ile Gln Cys Thr Arg
              20                  25                  30        
 Tyr Ser Glu Ala Cys Thr Met Asp Tyr Thr Leu His Cys Gly Ser Asp
          35                  40                  45            
 Gly Asn Val Tyr Ser Asn Arg Cys Thr Phe Cys Asn Thr Val Val Lys
      50                  55                  60                
 Ser Gln Gly Ala Ile Trp Leu Lys Asn Tyr Gly Leu Cys
  65                  70                  75        



      <210> 2776
      <211> 25
      <212> PRT
      <213> Homo sapiens


      <400> 2776
 Ala Ala Ser Thr Cys Ile Ala Gly Glu Arg Arg Tyr Gly Thr Cys Ile
   1               5                  10                  15    
 Tyr Gln Gly Arg Leu Trp Ala Phe Cys
              20                  25



      <210> 2777
      <211> 153
      <212> PRT
      <213> Homo sapiens


      <400> 2777
 Gln Gln Leu Glu Gly Arg Gly Gly Gly Ala Gly Cys Pro Val Leu Ala
   1               5                  10                  15    
 Met Arg Pro Gln Gln Ala Pro Val Ser Gly Lys Val Phe Ile Gln Arg
              20                  25                  30        
 Asp Tyr Ser Ser Gly Thr Arg Cys Gln Phe Gln Thr Lys Phe Pro Ala
          35                  40                  45            
 Glu Leu Glu Asn Arg Ile Asp Arg Gln Gln Phe Glu Glu Thr Val Arg
      50                  55                  60                
 Thr Leu Asn Asn Leu Tyr Ala Glu Ala Glu Lys Leu Gly Gly Gln Ser
  65                  70                  75                  80
 Tyr Leu Glu Gly Cys Leu Ala Cys Leu Thr Ala Tyr Thr Ile Phe Leu
                  85                  90                  95    
 Cys Met Glu Thr His Tyr Glu Lys Val Leu Lys Lys Val Ser Lys Tyr
             100                 105                 110        
 Ile Gln Glu Gln Asn Glu Lys Ile Tyr Ala Pro Gln Gly Leu Leu Leu
         115                 120                 125            
 Thr Asp Pro Ile Glu Arg Gly Leu Arg Val Ile Glu Ile Thr Ile Tyr
     130                 135                 140                
 Glu Asp Arg Gly Met Ser Ser Gly Arg
 145                 150            



      <210> 2778
      <211> 146
      <212> PRT
      <213> Homo sapiens


      <400> 2778
 Leu His Thr Cys Val Pro Thr Ser Cys Cys Phe Leu Ser Gln Asn Lys
   1               5                  10                  15    
 Gly Val Cys Ser Arg Gly Ile Ser Lys Cys Pro Ala Phe Pro Thr Glu
              20                  25                  30        
 Val Ala Phe Ala Leu Asp Met Ser Asn Asp Val Ser Leu Leu Asp Phe
          35                  40                  45            
 Glu Arg Met Arg Asp Ile Leu Leu Ser Leu Leu Met Lys Met Glu Ile
      50                  55                  60                
 Ser Asp Ser Asn Cys Pro Thr Gly Ala Arg Val Ala Ile Val Ser Tyr
  65                  70                  75                  80
 Asn Ala Lys Thr Asn Tyr Leu Val Arg Phe Ser Asp Tyr Lys Gly Lys
                  85                  90                  95    
 Val Ala Leu Leu Glu Ala Val Arg Asn Ile Pro Leu Glu Gln Ser Ser
             100                 105                 110        
 Gly Arg Arg Asn Leu Gly Ala Thr Met Arg Phe Met Ala Arg Asn Val
         115                 120                 125            
 Phe Lys Arg Val Arg Ser Gly Leu Leu Met Arg Lys Val Ala Val Phe
     130                 135                 140                
 Phe Gln
 145    



      <210> 2779
      <211> 214
      <212> PRT
      <213> Homo sapiens


      <400> 2779
 Ala Gly Thr Ser Pro Pro Gly Pro Gly Arg Pro Pro Ala Ala Gly Lys
   1               5                  10                  15    
 Met Pro Glu Gln Ser Asn Asp Tyr Arg Val Val Val Phe Gly Ala Gly
              20                  25                  30        
 Gly Val Gly Lys Ser Ser Leu Val Leu Arg Phe Val Lys Gly Thr Phe
          35                  40                  45            
 Arg Asp Thr Tyr Ile Pro Thr Ile Glu Asp Thr Tyr Arg Gln Met Ile
      50                  55                  60                
 Ser Cys Asp Lys Ser Val Cys Thr Leu Gln Ile Thr Asp Thr Thr Gly
  65                  70                  75                  80
 Ser His Gln Phe Pro Ala Met Gln Arg Leu Ser Ile Ser Lys Gly His
                  85                  90                  95    
 Ala Phe Ile Leu Val Phe Ser Val Thr Ser Lys Gln Ser Leu Glu Glu
             100                 105                 110        
 Leu Gly Pro Ile Tyr Lys Leu Ile Val Gln Ile Lys Gly Ser Val Glu
         115                 120                 125            
 Asp Ile Pro Val Met Leu Val Gly Asn Lys Cys Asp Glu Thr Gln Arg
     130                 135                 140                
 Glu Val Asp Thr Arg Glu Ala Gln Ala Val Ala Gln Glu Trp Lys Cys
 145                 150                 155                 160
 Ala Phe Met Glu Thr Ser Ala Lys Met Asn Tyr Asn Val Lys Glu Leu
                 165                 170                 175    
 Phe Gln Glu Leu Leu Thr Leu Glu Thr Arg Arg Asn Met Ser Leu Asn
             180                 185                 190        
 Ile Asp Gly Lys Arg Ser Gly Lys Gln Lys Arg Thr Asp Arg Val Lys
         195                 200                 205            
 Gly Lys Cys Thr Leu Met
     210                



      <210> 2780
      <211> 91
      <212> PRT
      <213> Homo sapiens


      <400> 2780
 Ala Arg Gly Ser Cys Pro Thr Arg Pro Arg Pro Ala Asn Gly Arg Met
   1               5                  10                  15    
 Ala Glu Thr Lys Asp Ala Ala Gln Met Leu Val Thr Phe Lys Asp Val
              20                  25                  30        
 Ala Val Thr Phe Thr Arg Glu Glu Trp Arg Gln Leu Asp Leu Ala Gln
          35                  40                  45            
 Arg Thr Leu Tyr Arg Glu Val Met Leu Glu Thr Cys Gly Leu Leu Val
      50                  55                  60                
 Ser Leu Gly His Arg Val Pro Lys Pro Glu Leu Val His Leu Leu Lys
  65                  70                  75                  80
 His Gly Gln Glu Leu Trp Ile Val Lys Arg Gly
                  85                  90    



      <210> 2781
      <211> 229
      <212> PRT
      <213> Homo sapiens


      <400> 2781
 His Leu Asp Arg Tyr Ile Lys Ser Pro Gly Ser Gly Ser Ser Thr Pro
   1               5                  10                  15    
 Ala Pro Pro Ser His Leu Leu Leu Tyr Leu Leu His Pro Gln Ser Thr
              20                  25                  30        
 Arg Thr Met Gly Cys Cys Gly Cys Ser Arg Gly Cys Gly Ser Gly Cys
          35                  40                  45            
 Gly Gly Cys Gly Ser Ser Cys Gly Gly Cys Gly Ser Gly Cys Gly Gly
      50                  55                  60                
 Cys Gly Ser Gly Arg Gly Gly Cys Gly Ser Gly Cys Gly Gly Cys Ser
  65                  70                  75                  80
 Ser Ser Cys Gly Gly Cys Gly Ser Arg Cys Tyr Val Pro Val Cys Cys
                  85                  90                  95    
 Cys Lys Pro Val Cys Ser Trp Val Pro Ala Cys Ser Cys Thr Ser Cys
             100                 105                 110        
 Gly Ser Cys Gly Gly Ser Lys Gly Gly Cys Gly Ser Cys Gly Gly Ser
         115                 120                 125            
 Lys Gly Gly Cys Gly Ser Cys Gly Cys Ser Gln Ser Ser Cys Cys Lys
     130                 135                 140                
 Pro Cys Cys Cys Ser Ser Gly Cys Gly Ser Ser Cys Ser Gln Ser Ser
 145                 150                 155                 160
 Cys Cys Lys Pro Cys Cys Cys Ser Ser Gly Cys Gly Ser Ser Cys Cys
                 165                 170                 175    
 Gln Ser Ser Cys Cys Lys Pro Tyr Cys Cys Gln Ser Ser Cys Cys Lys
             180                 185                 190        
 Pro Cys Ser Cys Phe Ser Gly Cys Gly Ser Ser Cys Cys Gln Ser Ser
         195                 200                 205            
 Cys Tyr Lys Pro Cys Cys Cys Gln Ser Ser Cys Cys Val Pro Val Cys
     210                 215                 220                
 Cys Gln Cys Lys Ile
 225                



      <210> 2782
      <211> 120
      <212> PRT
      <213> Homo sapiens

      <220>
      <221> misc_feature
      <222> (1)...(120)
      <223> Xaa = any amino acid or symbol as shown in the table 8 as set forth in Example 2


      <400> 2782
 Met Val Ser Ser Cys Cys Gly Ser Val Cys Ser Asp Gln Gly Cys Gly
   1               5                  10                  15    
 Gln Asp Leu Cys Gln Glu Thr Cys Cys Arg Pro Ser Cys Cys Glu Thr
              20                  25                  30        
 Thr Cys Cys Arg Thr Thr Cys Cys Arg Pro Ser Cys Cys Val Ser Ser
          35                  40                  45            
 Cys Cys Arg Pro Gln Cys Cys Gln Ser Val Cys Cys Gln Pro Thr Cys
      50                  55                  60                
 Ser Arg Pro Ser Cys Cys Gln Thr Thr Cys Cys Arg Thr Thr Cys Tyr
  65                  70                  75                  80
 Arg Pro Ser Cys Cys Val Ser Ser Cys Cys Arg Pro Gln Cys Cys Gln
                  85                  90                  95    
 Pro Val Cys Cys Gln Pro Thr Cys Cys Arg Pro Ser Cys Cys Glu Thr
             100                 105                 110        
 Thr Cys Cys His Pro Xaa Cys Cys
         115                 120



      <210> 2783
      <211> 128
      <212> PRT
      <213> Homo sapiens


      <400> 2783
 Pro Asp Pro Pro Arg Ser Asp Thr Met Val Ser Ser Cys Cys Gly Ser
   1               5                  10                  15    
 Val Cys Ser Asp Gln Gly Cys Gly Gln Val Leu Cys Gln Glu Thr Cys
              20                  25                  30        
 Cys Arg Pro Ser Cys Cys Gln Thr Thr Cys Cys Arg Thr Thr Cys Tyr
          35                  40                  45            
 Arg Pro Ser Cys Cys Val Ser Ser Cys Cys Arg Pro Gln Cys Cys Gln
      50                  55                  60                
 Ser Val Cys Cys Gln Pro Thr Cys Cys Arg Pro Ser Cys Cys Glu Thr
  65                  70                  75                  80
 Thr Cys Cys His Pro Arg Cys Cys Ile Ser Ser Cys Cys Arg Pro Ser
                  85                  90                  95    
 Cys Cys Met Ser Ser Cys Cys Lys Pro Gln Cys Cys Gln Ser Val Cys
             100                 105                 110        
 Cys Gln Pro Thr Cys Cys His Pro Ser Cys Cys Ile Ser Ser Cys Cys
         115                 120                 125            





      <210> 2784
      <211> 222
      <212> PRT
      <213> Homo sapiens

      <220>
      <221> misc_feature
      <222> (1)...(222)
      <223> Xaa = any amino acid or symbol as shown in the table 8 as set forth in Example 2


      <400> 2784
 His Leu Asp Arg Tyr Ile Lys Ser Pro Gly Ser Gly Ser Ser Thr Pro
   1               5                  10                  15    
 Ala Pro Pro Ser His Leu Leu Leu Tyr Leu Leu His Pro Gln Ser Thr
              20                  25                  30        
 Arg Thr Met Gly Cys Cys Gly Cys Ser Arg Gly Cys Gly Ser Gly Cys
          35                  40                  45            
 Gly Gly Cys Gly Ser Ser Cys Gly Gly Cys Gly Ser Gly Cys Gly Gly
      50                  55                  60                
 Cys Gly Ser Gly Arg Gly Gly Cys Gly Ser Gly Cys Gly Gly Cys Ser
  65                  70                  75                  80
 Ser Ser Cys Gly Gly Cys Gly Ser Arg Cys Tyr Val Pro Val Cys Cys
                  85                  90                  95    
 Cys Lys Pro Val Cys Ser Trp Val Pro Ala Cys Ser Cys Thr Ser Cys
             100                 105                 110        
 Gly Ser Cys Gly Gly Ser Lys Gly Gly Cys Gly Ser Cys Gly Gly Ser
         115                 120                 125            
 Lys Gly Gly Cys Gly Ser Cys Gly Cys Ser Gln Ser Ser Cys Cys Lys
     130                 135                 140                
 Pro Cys Cys Cys Ser Ser Gly Cys Gly Ser Ser Cys Cys Gln Ser Ser
 145                 150                 155                 160
 Cys Cys Lys Pro Cys Cys Cys Gln Ser Ser Cys Cys Val Pro Val Cys
                 165                 170                 175    
 Cys Gln Ser Ser Cys Cys Lys Pro Cys Cys Cys Gln Ser Asn Cys Cys
             180                 185                 190        
 Val Pro Val Cys Cys Gln Cys Lys Ile Xaa Gly Ser Gly Pro Arg Pro
         195                 200                 205            
 Ser Gly Phe Ser Cys Leu Val Lys Ala Phe Leu Met Val Pro
     210                 215                 220        



      <210> 2785
      <211> 232
      <212> PRT
      <213> Homo sapiens

      <220>
      <221> misc_feature
      <222> (1)...(232)
      <223> Xaa = any amino acid or symbol as shown in the table 8 as set forth in Example 2


      <400> 2785
 Phe Val Arg Pro Leu Ser Met Trp Trp Asn Ser Asp Glu Arg Leu Tyr
   1               5                  10                  15    
 Glu Cys Thr Glu Cys Gly Lys Ala Phe Asn Asn Arg Ser Thr Leu Ile
              20                  25                  30        
 Gln His Gln Arg Ile His Thr Gly Glu Lys Ser Phe Glu Cys Lys Glu
          35                  40                  45            
 Cys Gly Lys Ala Phe Asn Asn Cys Ser Thr Leu Thr Gln His Gln Arg
      50                  55                  60                
 Thr His Thr Asn Glu Lys Ser Tyr Glu Cys Gln Glu Cys Lys Lys Ala
  65                  70                  75                  80
 Phe Arg Gln Ser Ala His Leu Thr Gln His Gln Arg Ile His Thr Gly
                  85                  90                  95    
 Glu Lys Pro Tyr Glu Cys Lys Xaa Cys Gly Lys Ala Phe Thr Cys Val
             100                 105                 110        
 Ser Asp Phe Asn Arg His Gln Arg Ile His Thr Gly Glu Lys Pro Tyr
         115                 120                 125            
 Glu Cys Lys Glu Cys Gly Arg Ala Phe Asn Asn Cys Ser Ala Leu Ile
     130                 135                 140                
 Gln His Gln Arg Ile His Thr Gly Glu Lys Ala Tyr Glu Tyr Lys Gln
 145                 150                 155                 160
 Cys Gly Lys Val Phe Val Ser Cys Pro Thr Leu Val Gln His Gln Arg
                 165                 170                 175    
 Thr His Thr Asn Glu Lys Pro Tyr Glu Cys Gln Xaa Cys Lys Lys Ala
             180                 185                 190        
 Phe Lys His Asn Ala His Leu Met Arg His Gln Arg Ile His Ser Gly
         195                 200                 205            
 Glu Lys Pro Tyr Glu Cys Asn Glu Cys Gly Asn Ala Phe Ile Cys Phe
     210                 215                 220                
 Phe Asp Phe Asn Arg His Gln Arg
 225                 230        



      <210> 2786
      <211> 73
      <212> PRT
      <213> Homo sapiens

      <220>
      <221> misc_feature
      <222> (1)...(73)
      <223> Xaa = any amino acid or symbol as shown in the table 8 as set forth in Example 2


      <400> 2786
 Gly Val Tyr Pro Pro Thr Val Phe Asp Asn Tyr Ser Val Gln Thr Ser
   1               5                  10                  15    
 Val Asp Gly Gln Ile Val Ser Leu Asn Thr Trp Asp Thr Ala Gly Gln
              20                  25                  30        
 Glu Glu Tyr Asp Arg Leu Arg Thr Leu Ser Xaa Pro Gln Thr Ser Ile
          35                  40                  45            
 Phe Val Ile Cys Phe Ser Ile Gly Asn Leu Glu Phe Pro Ile Tyr Gly
      50                  55                  60                
 Thr Trp Leu Ser Met Ser Met Gly Lys
  65                  70            



      <210> 2787
      <211> 544
      <212> PRT
      <213> Homo sapiens

      <220>
      <221> misc_feature
      <222> (1)...(544)
      <223> Xaa = any amino acid or symbol as shown in the table 8 as set forth in Example 2


      <400> 2787
 Asn His Lys Ser Pro Met Ala Leu Pro Tyr His Ile Phe Leu Phe Thr
   1               5                  10                  15    
 Val Leu Leu Pro Ser Phe Thr Leu Thr Ala Pro Pro Pro Cys Arg Cys
              20                  25                  30        
 Met Thr Ser Ser Ser Pro Tyr Gln Glu Phe Leu Trp Arg Met Gln Arg
          35                  40                  45            
 Pro Gly Asn Ile Asp Ala Pro Ser Tyr Arg Ser Leu Ser Lys Gly Thr
      50                  55                  60                
 Pro Thr Phe Thr Ala His Thr His Met Pro Arg Asn Cys Tyr His Ser
  65                  70                  75                  80
 Ala Thr Leu Cys Met His Ala Asn Thr His Tyr Trp Thr Gly Lys Met
                  85                  90                  95    
 Ile Asn Pro Ser Cys Pro Gly Gly Leu Gly Val Thr Val Cys Arg Thr
             100                 105                 110        
 Tyr Phe Thr Gln Thr Gly Met Ser Asp Gly Gly Gly Val Gln Asp Gln
         115                 120                 125            
 Ala Arg Glu Lys His Val Lys Glu Ala Ile Ser Gln Leu Thr Arg Gly
     130                 135                 140                
 His Ser Thr Pro Ser Pro Tyr Lys Gly Leu Val Leu Ser Lys Leu His
 145                 150                 155                 160
 Glu Thr Leu Arg Thr His Thr Arg Leu Val Ser Leu Phe Asn Thr Thr
                 165                 170                 175    
 Leu Thr Gly Leu His Glu Val Ser Ala Gln Asn Pro Thr Asn Cys Trp
             180                 185                 190        
 Ile Cys Leu Pro Leu Asn Phe Arg Pro Tyr Val Ser Ile Pro Val Pro
         195                 200                 205            
 Glu Gln Trp Asn Asn Phe Ser Thr Glu Ile Asn Thr Thr Ser Val Leu
     210                 215                 220                
 Val Gly Pro Leu Val Ser Asn Leu Glu Ile Thr His Thr Ser Asn Leu
 225                 230                 235                 240
 Thr Cys Val Lys Phe Ser Asn Thr Thr Tyr Thr Thr Asn Ser Gln Cys
                 245                 250                 255    
 Ile Arg Trp Val Thr Pro Pro Thr Gln Ile Val Cys Leu Pro Ser Gly
             260                 265                 270        
 Ile Phe Phe Val Cys Gly Thr Ser Ala Tyr Arg Cys Leu Asn Gly Ser
         275                 280                 285            
 Ser Glu Ser Met Cys Phe Leu Ser Phe Leu Val Pro Pro Met Thr Ile
     290                 295                 300                
 Tyr Thr Glu Gln Asp Leu Tyr Ser Tyr Val Ile Ser Xaa Ser Pro Arg
 305                 310                 315                 320
 Asn Lys Arg Val Pro Ile Leu Pro Phe Val Ile Gly Ala Gly Val Leu
                 325                 330                 335    
 Gly Gly Leu Gly Thr Gly Ile Gly Gly Ile Thr Thr Ser Thr Gln Phe
             340                 345                 350        
 Tyr His Lys Leu Ser Gln Glu Leu Asn Gly Asp Met Glu Gln Val Ala
         355                 360                 365            
 Asp Ser Leu Val Thr Leu Gln Asp Gln Leu Asn Ser Leu Ala Ala Val
     370                 375                 380                
 Val Leu Gln Asn Arg Arg Ala Leu Asp Leu Leu Thr Ala Glu Arg Gly
 385                 390                 395                 400
 Gly Thr Cys Leu Leu Leu Gly Glu Glu Cys Cys Tyr Tyr Val Asn Gln
                 405                 410                 415    
 Ser Gly Ile Val Thr Glu Lys Val Lys Glu Ile Arg Asp Arg Ile Gln
             420                 425                 430        
 Arg Arg Ala Glu Glu Leu Arg Asn Thr Gly Pro Trp Gly Leu Leu Ser
         435                 440                 445            
 Gln Trp Met Pro Trp Ile Leu Pro Phe Leu Gly Pro Leu Ala Ala Ile
     450                 455                 460                
 Ile Leu Leu Leu Leu Phe Gly Pro Cys Ile Phe Asn Leu Leu Val Asn
 465                 470                 475                 480
 Phe Val Ser Ser Arg Ile Glu Ala Val Lys Leu Gln Met Glu Pro Lys
                 485                 490                 495    
 Met Gln Ser Lys Thr Lys Ile Tyr Arg Arg Pro Leu Asp Arg Pro Ala
             500                 505                 510        
 Ser Pro Arg Ser Asp Val Asn Asp Ile Lys Gly Thr Pro Pro Glu Glu
         515                 520                 525            
 Ile Ser Ala Ala Gln Pro Leu Leu Arg Pro Asn Ser Ala Gly Ser Ser
     530                 535                 540                





      <210> 2788
      <211> 175
      <212> PRT
      <213> Homo sapiens

      <220>
      <221> misc_feature
      <222> (1)...(175)
      <223> Xaa = any amino acid or symbol as shown in the table 8 as set forth in Example 2


      <400> 2788
 Glu Val Cys Ala Cys Val Gln Ala Phe Trp Leu Val Ala Ser Ser Gly
   1               5                  10                  15    
 Asp Asp Ser Gln Gly Gly Asp Lys Cys Gly Cys Glu Val Gly Ser Trp
              20                  25                  30        
 Val Gly Ser Met Arg Val Val Met Ala Arg Leu Leu Ser Glu Gly Glu
          35                  40                  45            
 Gln Gly Ile Pro Thr Ala Cys Ala Ala Phe Ala Gln Gln Pro Ala Gly
      50                  55                  60                
 Glu Pro Arg Arg Gly Leu Ala Gly Val Gly Glu Gly Gly Pro Gln Cys
  65                  70                  75                  80
 Ser Trp Val Asn Tyr Arg Cys Thr Leu Glu Phe Leu Val Ser Leu Leu
                  85                  90                  95    
 Gly Thr Asp Leu Ala Arg Gly Arg Gly Asn Ser Ala Ser Gly Pro Thr
             100                 105                 110        
 Ala Pro Ala Asp Ser Lys Gln Leu Met Leu Xaa Asp Val His Arg Arg
         115                 120                 125            
 Val Ile Leu Glu Xaa Arg Met Asn Ser Gly Ser Pro Ala Arg Asp Asn
     130                 135                 140                
 Ala Pro Ser Gln Arg Phe Cys Thr Asn Leu Ser Glu Gly Leu Arg Phe
 145                 150                 155                 160
 Gly Ile Ser Pro Ser Trp Arg Glu Ala Leu Tyr Gly Cys His Ala
                 165                 170                 175



      <210> 2789
      <211> 97
      <212> PRT
      <213> Homo sapiens


      <400> 2789
 Arg Phe Val Cys Ser Thr Ile Lys Val Leu Arg Asp Leu Ser Ser Asp
   1               5                  10                  15    
 Arg Ser Asn Pro Gly Arg Phe Leu Ser Thr Ser Asn Ser Ser Leu Lys
              20                  25                  30        
 Lys Lys Lys Lys Lys Lys Lys Lys Lys Lys Lys Lys Lys Lys Lys Lys
          35                  40                  45            
 Lys Lys Lys Lys Lys Lys Lys Lys Lys Lys Lys Lys Lys Lys Lys Lys
      50                  55                  60                
 Lys Gly Gly Gly Gly Val Ile Lys Lys Phe Leu Gly Gly Pro Ile Phe
  65                  70                  75                  80
 Gly Gly Gly Gly Lys Glu Lys Phe Phe Phe Phe Gly Gly Gly Phe Ile
                  85                  90                  95    
 Asn
    



      <210> 2790
      <211> 118
      <212> PRT
      <213> Homo sapiens


      <400> 2790
 Pro Val Cys Thr Val Ser Gly Pro Met Ala Pro Gly Ala Ser Ser Ser
   1               5                  10                  15    
 His Pro Val Leu Pro Leu Leu Gly Leu Leu Glu Pro Ala Gly Leu Ala
              20                  25                  30        
 Glu Leu Gly Arg Thr His Pro Ile Thr Met Ser Thr Val Val Leu Leu
          35                  40                  45            
 Leu Gln Arg Ser Val Ser Asn Ala Ala Thr Arg Val Cys Arg Thr Gly
      50                  55                  60                
 Arg Ser Arg Trp Arg Asp Val Cys Arg Asn Phe Met Arg Arg Tyr Gln
  65                  70                  75                  80
 Ser Arg Val Ile Gln Gly Leu Val Ala Gly Glu Thr Ala Gln Gln Ile
                  85                  90                  95    
 Cys Glu Asp Leu Arg Leu Cys Ile Pro Ser Thr Gly Glu Cys Arg Gly
             100                 105                 110        
 Asp Ser Arg Asp Thr Ser
         115            

      <210> 2791
      <211> 488
      <212> PRT
      <213> Homo sapiens

      <220>
      <221> misc_feature
      <222> (1)...(488)
      <223> Xaa = any amino acid or symbol as shown in the table 8 as set forth in Example 2


      <400> 2791
 Arg Asn Phe Arg Val Asp Asp Phe Val Ala Glu Leu Lys Leu Lys Gln
   1               5                  10                  15    
 Val Arg Trp Thr Pro Ala Ala Pro Xaa Ser Lys Glu Thr Thr Gln Gly
              20                  25                  30        
 Leu Arg Arg Leu His Val Asn Gly Arg Cys Glu Pro Lys Gly Leu Asp
          35                  40                  45            
 Pro Glu Met Gly Arg Arg Ser Ser Asp Thr Glu Glu Glu Ser Arg Ser
      50                  55                  60                
 Lys Arg Lys Lys Lys His Arg Arg Arg Ser Ser Ser Ser Ser Ser Ser
  65                  70                  75                  80
 Asp Ser Arg Thr Tyr Ser Arg Lys Lys Gly Gly Arg Lys Ser Arg Ser
                  85                  90                  95    
 Lys Ser Arg Ser Trp Ser Arg Asp Leu Gln Pro Arg Ser His Ser Tyr
             100                 105                 110        
 Asp Arg Arg Arg Arg His Arg Ser Ser Ser Ser Ser Ser Tyr Gly Ser
         115                 120                 125            
 Arg Arg Lys Arg Ser Arg Ser Arg Ser Arg Gly Arg Gly Lys Ser Tyr
     130                 135                 140                
 Arg Val Gln Arg Ser Arg Ser Lys Ser Arg Thr Arg Arg Ser Arg Ser
 145                 150                 155                 160
 Arg Pro Arg Leu Arg Ser His Ser Arg Ser Ser Glu Arg Ser Ser His
                 165                 170                 175    
 Arg Arg Thr Arg Ser Arg Ser Arg Asp Arg Glu Arg Arg Lys Gly Arg
             180                 185                 190        
 Asp Lys Glu Lys Arg Glu Lys Glu Lys Asp Lys Gly Lys Asp Lys Glu
         195                 200                 205            
 Leu His Asn Ile Lys Arg Gly Glu Ser Gly Asn Ile Lys Ala Gly Leu
     210                 215                 220                
 Glu His Ser Ala Thr Ser Xaa Thr Gly Gln Ser Gln Thr Thr Ala Gly
 225                 230                 235                 240
 Ser Xaa Ser Cys Cys Lys Ser Xaa Xaa Ser Ile Glu Ser Gln Arg Lys
                 245                 250                 255    
 Lys Xaa Gly Arg Ser Lys Glu Gln Glu Arg Arg Lys Thr Lys Pro Pro
             260                 265                 270        
 Trp Xaa Asn Lys Xaa Lys Glu Xaa Lys Phe Gly Gly Arg Arg Arg Arg
         275                 280                 285            
 Pro Asp Leu Lys Lys Arg Leu Arg Asp Cys Gly Ala Cys Thr Ser Thr
     290                 295                 300                
 Gly Gly Val Ser Pro Lys Val Trp Thr Gln Lys Trp Asp Val Gly His
 305                 310                 315                 320
 Gln Ile Leu Lys Lys Lys Ala Glu Ala Arg Glu Lys Arg Asn Thr Val
                 325                 330                 335    
 Asp Gly Pro Pro Arg Ala Val Leu Gln Ile Val Glu His Thr Ala Glu
             340                 345                 350        
 Arg Lys Glu Glu Gly Asn Gln Asp Gln Ser Gln Asp Leu Gly Pro Glu
         355                 360                 365            
 Ile Phe Ser Leu Val His Ile Leu Met Ile Glu Asp Ala Gly Ile Asp
     370                 375                 380                
 Gln Ala Val Ala Leu Leu Met Ala Pro Glu Gly Asn Glu Val Glu Val
 385                 390                 395                 400
 Val Gln Gly Val Glu Gly Asn Pro Ile Glu Phe Arg Gly Leu Gly Gln
                 405                 410                 415    
 Lys Ala Glu Gln Glu Gly Pro Gly Gln Asp Leu Val Ser Val Leu Ile
             420                 425                 430        
 Val Val Ala Val Lys Gly Pro Val Thr Glu Glu Arg Val Val Gly Leu
         435                 440                 445            
 Gly Ile Glu Asn Asp Val Arg Ala Glu Ile Lys Arg Lys Glu Lys Arg
     450                 455                 460                
 Arg Arg Ile Lys Gly Arg Thr Arg Asn Tyr Ile Thr Ser Asn Val Gly
 465                 470                 475                 480
 Asn Leu Glu Thr Ser Lys Leu Asp
                 485            



      <210> 2792
      <211> 205
      <212> PRT
      <213> Homo sapiens


      <400> 2792
 Gln Pro Ala Pro Cys His Ala Glu Leu Gly Pro Ala Gly Gln Ser Pro
   1               5                  10                  15    
 Leu Leu Val Pro Pro Leu Gly Pro Gln Asn Pro Gly Ala Gly Ala Ala
              20                  25                  30        
 Trp Asp Pro Pro Glu Asn Leu Arg Val Met Val Ser Gln Ala Asn Arg
          35                  40                  45            
 Thr Val Leu Glu Asn Leu Gly Asn Gly Thr Ser Leu Pro Val Leu Glu
      50                  55                  60                
 Gly Gln Ser Leu Arg Leu Val Cys Val Thr His Ser Ser Pro Pro Ala
  65                  70                  75                  80
 Arg Leu Ser Trp Thr Arg Trp Gly Gln Thr Val Gly Pro Ser Gln Pro
                  85                  90                  95    
 Ser Asp Pro Gly Val Leu Glu Leu Pro Pro Ile Gln Met Glu His Glu
             100                 105                 110        
 Gly Glu Phe Thr Cys His Ala Gln His Pro Leu Gly Ser Gln His Val
         115                 120                 125            
 Ser Leu Ser Leu Ser Val His Trp Lys Leu Glu His Gly Gly Gly Leu
     130                 135                 140                
 Gly Leu Gly Ala Ala Leu Gly Ala Gly Val Ala Ala Leu Leu Ala Phe
 145                 150                 155                 160
 Cys Ser Cys Leu Val Val Phe Arg Val Lys Ile Cys Arg Lys Glu Ala
                 165                 170                 175    
 Arg Lys Arg Ala Ala Ala Glu Gln Asp Val Pro Ser Thr Leu Gly Pro
             180                 185                 190        
 Ile Ser Gln Gly His Gln His Glu Cys Ser Ala Gly Ser
         195                 200                 205



      <210> 2793
      <211> 130
      <212> PRT
      <213> Homo sapiens


      <400> 2793
 His Thr Ile Glu Lys Pro Tyr Glu Cys Lys Glu Cys Leu Lys Ser Phe
   1               5                  10                  15    
 Leu Tyr Pro Ser Arg Leu Thr Arg His Gln Lys Ile His Thr Gly Lys
              20                  25                  30        
 Lys Pro Phe Glu Cys Lys Glu Cys Gly Lys Thr Phe Ile Cys Gly Ser
          35                  40                  45            
 Asp Leu Thr Arg His His Arg Ile His Thr Gly Glu Lys Pro Tyr Glu
      50                  55                  60                
 Cys Lys Glu Cys Gly Lys Ala Phe Ser Ser Gly Ser Asn Phe Thr Arg
  65                  70                  75                  80
 His Gln Arg Ile His Thr Gly Glu Lys Pro Tyr Glu Cys Lys Glu Cys
                  85                  90                  95    
 Gly Lys Ala Phe Ser Ser Gly Ser Asn Phe Ile Gln His Gln Arg Ile
             100                 105                 110        
 His Thr Gly Glu Lys Pro Tyr Glu Cys Lys Glu Cys Gly Asn Ala Phe
         115                 120                 125            
 Ser Gln
     130



      <210> 2794
      <211> 151
      <212> PRT
      <213> Homo sapiens

      <220>
      <221> misc_feature
      <222> (1)...(151)
      <223> Xaa = any amino acid or symbol as shown in the table 8 as set forth in Example 2


      <400> 2794
 Ala Ala Pro Met Glu Leu Ile Cys Trp Ser Gly Gly Trp Gly Leu Pro
   1               5                  10                  15    
 Ser Val Asp Leu Asp Ser Leu Ala Val Leu Thr Tyr Ala Arg Phe Thr
              20                  25                  30        
 Gly Ala Pro Leu Lys Val His Lys Ile Ile Asn Pro Trp Xaa Ser Pro
          35                  40                  45            
 Ser Gly Thr Leu Pro Ala Leu Arg Thr Ser His Gly Glu Val Ile Ser
      50                  55                  60                
 Val Pro His Lys Ile Ile Thr His Leu Leu Lys Glu Lys Tyr Asn Ala
  65                  70                  75                  80
 Asp Tyr Asp Leu Ser Ala Arg Gln Gly Ala Asp Thr Leu Ala Phe Met
                  85                  90                  95    
 Ser Leu Leu Glu Glu Lys Leu Leu Pro Gly Leu Val His Thr Phe Trp
             100                 105                 110        
 Ile Asp Thr Lys Asn Tyr Leu Glu Val Thr Arg Lys Trp Tyr Ala Glu
         115                 120                 125            
 Ala Met Pro Phe Ser Leu Asn Phe Phe Leu Pro Gly Arg Met Gln Arg
     130                 135                 140                
 Gln Tyr Met Xaa Arg Leu Pro
 145                 150    



      <210> 2795
      <211> 138
      <212> PRT
      <213> Homo sapiens


      <400> 2795
 Asp Ala Trp Ala Asp Ala Trp Ala Asp Ala Trp Ala Asp Ala Trp Ala
   1               5                  10                  15    
 Arg Ala Ser Trp Ala Phe Ser His Arg Phe Pro Ser Pro Leu Ala Pro
              20                  25                  30        
 Arg Arg Ser Pro Thr Pro Phe Phe Met Ala Ser Leu Leu Cys Cys Gly
          35                  40                  45            
 Pro Lys Leu Ala Ala Cys Gly Ile Val Leu Ser Ala Trp Gly Val Ile
      50                  55                  60                
 Met Leu Ile Met Leu Gly Ile Phe Phe Asn Val His Ser Ala Val Leu
  65                  70                  75                  80
 Ile Glu Asp Val Pro Phe Thr Glu Lys Asp Phe Glu Asn Gly Pro Gln
                  85                  90                  95    
 Asn Ile Tyr Asn Leu Tyr Glu Gln Val Ser Tyr Asn Cys Phe Ile Ala
             100                 105                 110        
 Ala Gly Leu Tyr Leu Leu Leu Gly Gly Phe Ser Phe Cys Gln Val Arg
         115                 120                 125            
 Leu Asn Lys Arg Lys Glu Tyr Met Val Arg
     130                 135            



      <210> 2796
      <211> 51
      <212> PRT
      <213> Homo sapiens


      <400> 2796
 Met Gln Arg Lys Arg Gln Arg Tyr Pro Gly His Leu Gly Leu Val Phe
   1               5                  10                  15    
 Ile Val Leu Gly Ser Leu Ile Leu Asn Lys His Ser Leu Lys Glu Leu
              20                  25                  30        
 Leu Ile Pro Arg Ser Lys Phe Ser Leu Ser Lys Val Asp Phe Arg Leu
          35                  40                  45            
 Leu Lys Glu
      50    



      <210> 2797
      <211> 51
      <212> PRT
      <213> Homo sapiens


      <400> 2797
 Met Gln Arg Lys Arg Gln Arg Tyr Pro Gly His Leu Gly Leu Val Phe
   1               5                  10                  15    
 Ile Val Leu Gly Ser Leu Ile Leu Asn Lys His Ser Leu Lys Glu Leu
              20                  25                  30        
 Leu Ile Pro Arg Ser Lys Phe Ser Leu Ser Lys Val Asp Phe Arg Leu
          35                  40                  45            
 Leu Lys Glu
      50    



      <210> 2798
      <211> 586
      <212> PRT
      <213> Homo sapiens


      <400> 2798
 Gly Met Gly Ala Ala Met Pro Leu Ala Leu Leu Val Leu Leu Leu Leu
   1               5                  10                  15    
 Gly Pro Gly Gly Trp Cys Leu Ala Glu Pro Pro Arg Asp Ser Leu Arg
              20                  25                  30        
 Glu Glu Leu Val Ile Thr Pro Leu Pro Ser Gly Asp Val Ala Ala Thr
          35                  40                  45            
 Phe Gln Phe Arg Thr Arg Trp Asp Ser Glu Leu Gln Arg Glu Gly Val
      50                  55                  60                
 Ser His Tyr Arg Leu Phe Pro Lys Ala Leu Gly Gln Leu Ile Ser Lys
  65                  70                  75                  80
 Tyr Ser Leu Arg Glu Leu His Leu Ser Phe Thr Gln Gly Phe Trp Arg
                  85                  90                  95    
 Thr Arg Tyr Trp Gly Pro Pro Phe Leu Gln Ala Pro Ser Gly Ala Glu
             100                 105                 110        
 Leu Trp Val Trp Phe Gln Asp Thr Val Thr Asp Val Asp Lys Ser Trp
         115                 120                 125            
 Lys Glu Leu Ser Asn Val Leu Ser Gly Ile Phe Cys Ala Ser Leu Asn
     130                 135                 140                
 Phe Ile Asp Ser Thr Asn Thr Val Thr Pro Thr Ala Ser Phe Lys Pro
 145                 150                 155                 160
 Leu Gly Leu Ala Asn Asp Thr Asp His Tyr Phe Leu Arg Tyr Ala Val
                 165                 170                 175    
 Leu Pro Arg Glu Val Val Cys Thr Glu Asn Leu Thr Pro Trp Lys Lys
             180                 185                 190        
 Leu Leu Pro Cys Ser Ser Lys Ala Gly Leu Ser Val Leu Leu Lys Ala
         195                 200                 205            
 Asp Arg Leu Phe His Thr Ser Tyr His Ser Gln Ala Val His Ile Arg
     210                 215                 220                
 Pro Val Cys Arg Asn Ala Arg Cys Thr Ser Ile Ser Trp Glu Leu Arg
 225                 230                 235                 240
 Gln Thr Leu Ser Val Val Phe Asp Ala Phe Ile Thr Gly Gln Gly Lys
                 245                 250                 255    
 Lys Asp Trp Ser Leu Phe Arg Met Phe Ser Arg Thr Leu Thr Glu Pro
             260                 265                 270        
 Cys Pro Leu Ala Ser Glu Ser Arg Val Tyr Val Asp Ile Thr Thr Tyr
         275                 280                 285            
 Asn Gln Ala Leu Pro Leu Cys Pro Gln Asp Asn Glu Thr Leu Glu Val
     290                 295                 300                
 His Pro Pro Pro Thr Thr Thr Tyr Gln Asp Val Ile Leu Gly Thr Arg
 305                 310                 315                 320
 Lys Thr Tyr Ala Ile Tyr Asp Leu Leu Asp Thr Ala Met Ile Asn Asn
                 325                 330                 335    
 Ser Arg Asn Leu Asn Ile Gln Leu Lys Trp Lys Arg Pro Pro Glu Asn
             340                 345                 350        
 Glu Ala Pro Pro Val Pro Phe Leu His Ala Gln Arg Tyr Val Ser Gly
         355                 360                 365            
 Tyr Gly Leu Gln Lys Gly Glu Leu Ser Thr Leu Leu Tyr Asn Thr His
     370                 375                 380                
 Pro Tyr Arg Ala Phe Pro Val Leu Leu Leu Asp Thr Val Pro Trp Tyr
 385                 390                 395                 400
 Leu Arg Leu Tyr Val His Thr Leu Thr Ile Thr Ser Lys Gly Lys Glu
                 405                 410                 415    
 Asn Lys Pro Ser Tyr Ile His Tyr Gln Pro Ala Gln Asp Arg Leu Gln
             420                 425                 430        
 Pro His Leu Leu Glu Met Leu Ile Gln Leu Pro Ala Asn Ser Val Thr
         435                 440                 445            
 Lys Val Ser Ile Gln Phe Glu Arg Ala Leu Leu Lys Trp Thr Glu Tyr
     450                 455                 460                
 Thr Pro Asp Pro Asn His Gly Phe Tyr Val Ser Pro Ser Val Leu Ser
 465                 470                 475                 480
 Ala Leu Val Pro Ser Met Val Ala Ala Lys Pro Val Asp Trp Glu Glu
                 485                 490                 495    
 Ser Pro Leu Phe Asn Ser Leu Phe Pro Val Ser Asp Gly Ser Asn Tyr
             500                 505                 510        
 Phe Val Arg Leu Tyr Thr Glu Pro Leu Leu Val Asn Leu Pro Thr Pro
         515                 520                 525            
 Asp Phe Ser Met Pro Tyr Asn Val Ile Cys Leu Thr Cys Thr Val Val
     530                 535                 540                
 Ala Val Cys Tyr Gly Ser Phe Tyr Asn Leu Leu Thr Arg Thr Phe His
 545                 550                 555                 560
 Ile Glu Glu Pro Arg Thr Gly Gly Leu Ala Lys Arg Leu Ala Asn Leu
                 565                 570                 575    
 Ile Arg Arg Ala Arg Gly Val Pro Pro Leu
             580                 585    



      <210> 2799
      <211> 57
      <212> PRT
      <213> Homo sapiens


      <400> 2799
 Met Gln Gly Val Arg Val Ser Phe Gly Trp Ala Met Gly Leu Ala Trp
   1               5                  10                  15    
 Gly Ser Cys Ala Leu Glu Ala Phe Ser Gly Thr Leu Leu Leu Ser Ala
              20                  25                  30        
 Ala Trp Thr Leu Ser Leu Ser Pro Pro Ile Cys Gly His Leu Ser Pro
          35                  40                  45            
 Gln Gln Val Gly Gly Arg Gly Gly Asp
      50                  55        



      <210> 2800
      <211> 57
      <212> PRT
      <213> Homo sapiens


      <400> 2800
 Met Gln Gly Val Arg Val Ser Phe Gly Trp Ala Met Gly Leu Ala Trp
   1               5                  10                  15    
 Gly Ser Cys Ala Leu Glu Ala Phe Ser Gly Thr Leu Leu Leu Ser Ala
              20                  25                  30        
 Ala Trp Thr Leu Ser Leu Ser Pro Pro Ile Cys Gly His Leu Ser Pro
          35                  40                  45            
 Gln Gln Val Gly Gly Arg Gly Gly Asp
      50                  55        



      <210> 2801
      <211> 139
      <212> PRT
      <213> Homo sapiens


      <400> 2801
 Gly Phe Gly Arg Gly Ala Leu Ile Arg Leu Asn Ile Trp Pro Ala Val
   1               5                  10                  15    
 Gln Gly Ala Cys Lys Gln Leu Glu Val Cys Glu His Cys Val Glu Gly
              20                  25                  30        
 Asp Arg Ala Arg Asn Leu Ser Ser Cys Met Trp Glu Gln Cys Arg Pro
          35                  40                  45            
 Glu Glu Pro Gly His Cys Val Ala Gln Ser Glu Val Val Lys Glu Gly
      50                  55                  60                
 Cys Ser Ile Tyr Asn Arg Ser Glu Ala Cys Pro Ala Ala His His His
  65                  70                  75                  80
 Pro Thr Tyr Glu Pro Lys Thr Val Thr Thr Gly Ser Pro Pro Val Pro
                  85                  90                  95    
 Glu Ala His Ser Pro Gly Phe Asp Gly Ala Ser Phe Ile Gly Gly Val
             100                 105                 110        
 Val Leu Val Leu Ser Leu Gln Ala Val Ala Phe Phe Val Leu His Phe
         115                 120                 125            
 Leu Lys Ala Lys Asp Ser Thr Tyr Gln Thr Leu
     130                 135                



      <210> 2802
      <211> 345
      <212> PRT
      <213> Homo sapiens


      <400> 2802
 Arg His Gly His Gly Gly Arg Asp Arg Arg Gly Gly Gly Arg Val Ala
   1               5                  10                  15    
 Arg Pro Gly Gly Leu Gly Arg Tyr Pro Gly Arg Gly Ala Ala Ala Ser
              20                  25                  30        
 Leu Val Phe Val Pro Thr Arg Arg Arg Ser Gly Pro Ser Gly Thr Ala
          35                  40                  45            
 Ser Val Ala Ala Met Ala Tyr His Ser Gly Tyr Gly Ala His Gly Ser
      50                  55                  60                
 Lys His Arg Ala Arg Ala Ala Pro Asp Pro Pro Pro Leu Phe Asp Asp
  65                  70                  75                  80
 Thr Ser Gly Gly Tyr Ser Ser Gln Pro Gly Gly Tyr Pro Ala Thr Gly
                  85                  90                  95    
 Ala Asp Val Ala Phe Ser Val Asn His Leu Leu Gly Asp Pro Met Ala
             100                 105                 110        
 Asn Val Ala Met Ala Tyr Gly Ser Ser Ile Ala Ser His Gly Lys Asp
         115                 120                 125            
 Met Val His Lys Glu Leu His Arg Phe Val Ser Val Ser Lys Leu Lys
     130                 135                 140                
 Tyr Phe Phe Ala Val Asp Thr Ala Tyr Val Ala Lys Lys Leu Gly Leu
 145                 150                 155                 160
 Leu Val Phe Pro Tyr Thr His Gln Asn Trp Glu Val Gln Tyr Ser Arg
                 165                 170                 175    
 Asp Ala Pro Leu Pro Pro Arg Gln Asp Leu Asn Ala Pro Asp Leu Tyr
             180                 185                 190        
 Ile Pro Thr Met Ala Phe Ile Thr Tyr Val Leu Leu Ala Gly Met Ala
         195                 200                 205            
 Leu Gly Ile Gln Lys Arg Phe Ser Pro Glu Val Leu Gly Leu Cys Ala
     210                 215                 220                
 Ser Thr Ala Leu Val Trp Val Val Met Glu Val Leu Ala Leu Leu Leu
 225                 230                 235                 240
 Gly Leu Tyr Leu Ala Thr Val Arg Ser Asp Leu Ser Thr Phe His Leu
                 245                 250                 255    
 Leu Ala Tyr Ser Gly Tyr Lys Tyr Val Gly Met Ile Leu Ser Val Leu
             260                 265                 270        
 Thr Gly Leu Leu Phe Gly Ser Asp Gly Tyr Tyr Val Ala Leu Ala Trp
         275                 280                 285            
 Thr Ser Ser Ala Leu Met Tyr Phe Ile Val Arg Ser Leu Arg Thr Ala
     290                 295                 300                
 Ala Leu Gly Pro Asp Ser Met Gly Gly Pro Val Pro Arg Gln Arg Leu
 305                 310                 315                 320
 Gln Leu Tyr Leu Thr Leu Gly Ala Ala Ala Phe Gln Pro Leu Ile Ile
                 325                 330                 335    
 Tyr Trp Leu Thr Phe His Leu Val Arg
             340                 345



      <210> 2803
      <211> 311
      <212> PRT
      <213> Homo sapiens


      <400> 2803
 Met Gly Ser Arg Leu Leu Cys Trp Val Leu Leu Cys Leu Leu Gly Ala
   1               5                  10                  15    
 Gly Pro Val Lys Ala Gly Val Thr Gln Thr Pro Lys His Leu Ile Thr
              20                  25                  30        
 Ala Thr Gly Gln Gln Val Thr Leu Arg Cys Ser Pro Arg Ser Gly Asp
          35                  40                  45            
 Leu Ser Val Ser Trp Tyr Gln Gln Ser Leu Asp Gln Gly Leu Gln Phe
      50                  55                  60                
 Leu Ile Gln Tyr Tyr Asn Gly Glu Glu Arg Ala Lys Gly Asn Ile Leu
  65                  70                  75                  80
 Glu Arg Phe Ser Ala Gln Gln Phe Pro Asp Leu His Ser Glu Leu Asn
                  85                  90                  95    
 Leu Ser Ser Leu Glu Leu Gly Asp Ser Ala Leu Tyr Phe Cys Ala Ser
             100                 105                 110        
 Ser Val Lys Val Gly Thr Gly Glu Leu Phe Phe Gly Glu Gly Ser Arg
         115                 120                 125            
 Leu Thr Val Leu Glu Asp Leu Lys Asn Val Phe Pro Pro Glu Val Ala
     130                 135                 140                
 Val Phe Glu Pro Ser Glu Ala Glu Ile Ser His Thr Gln Lys Ala Thr
 145                 150                 155                 160
 Leu Val Cys Leu Ala Thr Gly Phe Tyr Pro Asp His Val Glu Leu Ser
                 165                 170                 175    
 Trp Trp Val Asn Gly Lys Glu Val His Ser Gly Val Ser Thr Asp Pro
             180                 185                 190        
 Gln Pro Leu Lys Glu Gln Pro Ala Leu Asn Asp Ser Arg Tyr Cys Leu
         195                 200                 205            
 Ser Ser Arg Leu Arg Val Ser Ala Thr Phe Trp Gln Asn Pro Arg Asn
     210                 215                 220                
 His Phe Arg Cys Gln Val Gln Phe Tyr Gly Leu Ser Glu Asn Asp Glu
 225                 230                 235                 240
 Trp Thr Gln Asp Arg Ala Lys Pro Val Thr Gln Ile Val Ser Ala Glu
                 245                 250                 255    
 Ala Trp Gly Arg Ala Asp Cys Gly Phe Thr Ser Glu Ser Tyr Gln Gln
             260                 265                 270        
 Gly Val Leu Ser Ala Thr Ile Leu Tyr Glu Ile Leu Leu Gly Lys Ala
         275                 280                 285            
 Thr Leu Tyr Ala Val Leu Val Ser Ala Leu Val Leu Met Ala Met Val
     290                 295                 300                
 Lys Arg Lys Asp Ser Arg Gly
 305                 310    



      <210> 2804
      <211> 130
      <212> PRT
      <213> Homo sapiens


      <400> 2804
 Glu Ile Gly Ala Glu Thr Gly Ala Arg Ser Gly Pro Gly Ala Glu Val
   1               5                  10                  15    
 Glu Thr Lys Ala Thr Ala Ile Ala Ile His Arg Ala Asn Ser Gln Ala
              20                  25                  30        
 Lys Ala Met Val Gly Ala Glu Pro Glu Thr Gln Ser Glu Ser Lys Val
          35                  40                  45            
 Val Ala Gly Thr Leu Val Met Thr Glu Ala Val Thr Leu Thr Glu Val
      50                  55                  60                
 Lys Ala Lys Ala Arg Glu Val Ala Met Lys Glu Ala Val Thr Gln Thr
  65                  70                  75                  80
 Asp Ala Glu Ala Gly Lys Ile Val Lys Lys Glu Ala Val Thr Gln Thr
                  85                  90                  95    
 Lys Ala Lys Ala Trp Ala Leu Val Ala Lys Thr Glu Ala Lys Arg Glu
             100                 105                 110        
 Ala Met Thr Gln Thr Lys Ala Glu Thr His Ile Leu Ala Glu Lys Glu
         115                 120                 125            
 Thr Val
     130



      <210> 2805
      <211> 557
      <212> PRT
      <213> Homo sapiens


      <400> 2805
 Met Arg Asp Tyr Asp Glu Val Thr Ala Phe Leu Gly Glu Trp Gly Pro
   1               5                  10                  15    
 Phe Gln Arg Leu Ile Phe Phe Leu Leu Ser Ala Ser Ile Ile Pro Asn
              20                  25                  30        
 Gly Phe Thr Gly Leu Ser Ser Val Phe Leu Ile Ala Thr Pro Glu His
          35                  40                  45            
 Arg Cys Arg Val Pro Asp Ala Ala Asn Leu Ser Ser Ala Trp Arg Asn
      50                  55                  60                
 His Thr Val Pro Leu Arg Leu Arg Asp Gly Arg Glu Val Pro His Ser
  65                  70                  75                  80
 Cys Arg Arg Tyr Arg Leu Ala Thr Ile Ala Asn Phe Ser Ala Leu Gly
                  85                  90                  95    
 Leu Glu Pro Gly Arg Asp Val Asp Leu Gly Gln Leu Glu Gln Glu Ser
             100                 105                 110        
 Cys Leu Asp Gly Trp Glu Phe Ser Gln Asp Val Tyr Leu Ser Thr Ile
         115                 120                 125            
 Val Thr Glu Trp Asn Leu Val Cys Glu Asp Asp Trp Lys Ala Pro Leu
     130                 135                 140                
 Thr Ile Ser Leu Phe Phe Val Gly Val Leu Leu Gly Ser Phe Ile Ser
 145                 150                 155                 160
 Gly Gln Leu Ser Asp Arg Phe Gly Arg Lys Asn Val Leu Phe Val Thr
                 165                 170                 175    
 Met Gly Met Gln Thr Gly Phe Ser Phe Leu Gln Ile Phe Ser Lys Asn
             180                 185                 190        
 Phe Glu Met Phe Val Val Leu Phe Val Leu Val Gly Met Gly Gln Ile
         195                 200                 205            
 Ser Asn Tyr Val Ala Ala Phe Val Leu Gly Thr Glu Ile Leu Gly Lys
     210                 215                 220                
 Ser Val Arg Ile Ile Phe Ser Thr Leu Gly Val Cys Ile Phe Tyr Ala
 225                 230                 235                 240
 Phe Gly Tyr Met Val Leu Pro Leu Phe Ala Tyr Phe Ile Arg Asp Trp
                 245                 250                 255    
 Arg Met Leu Leu Val Ala Leu Thr Met Pro Gly Val Leu Cys Val Ala
             260                 265                 270        
 Leu Trp Trp Phe Ile Pro Glu Ser Pro Arg Trp Leu Ile Ser Gln Gly
         275                 280                 285            
 Arg Phe Glu Glu Ala Glu Val Ile Ile Arg Lys Ala Ala Lys Ala Asn
     290                 295                 300                
 Gly Ile Val Val Pro Ser Thr Ile Phe Asp Pro Ser Glu Leu Gln Asp
 305                 310                 315                 320
 Leu Ser Ser Lys Lys Gln Gln Ser His Asn Ile Leu Asp Leu Leu Arg
                 325                 330                 335    
 Thr Trp Asn Ile Arg Met Val Thr Ile Met Ser Ile Met Leu Trp Met
             340                 345                 350        
 Thr Ile Ser Val Gly Tyr Phe Gly Leu Ser Leu Asp Thr Pro Asn Leu
         355                 360                 365            
 His Gly Asp Ile Phe Val Asn Cys Phe Leu Ser Ala Met Val Glu Val
     370                 375                 380                
 Pro Ala Tyr Val Leu Ala Trp Leu Leu Leu Gln Tyr Leu Pro Arg Arg
 385                 390                 395                 400
 Tyr Ser Met Ala Thr Ala Leu Phe Leu Gly Gly Ser Val Leu Leu Phe
                 405                 410                 415    
 Met Gln Leu Val Pro Pro Asp Leu Tyr Tyr Leu Ala Thr Val Leu Val
             420                 425                 430        
 Met Val Gly Lys Phe Gly Val Thr Ala Ala Phe Ser Met Val Tyr Val
         435                 440                 445            
 Tyr Thr Ala Glu Leu Tyr Pro Thr Val Val Arg Asn Met Gly Val Gly
     450                 455                 460                
 Val Ser Ser Thr Ala Ser Arg Leu Gly Ser Ile Leu Ser Pro Tyr Phe
 465                 470                 475                 480
 Val Tyr Leu Gly Ala Tyr Asp Arg Phe Leu Pro Tyr Ile Leu Met Gly
                 485                 490                 495    
 Ser Leu Thr Ile Leu Thr Ala Ile Leu Thr Leu Phe Leu Pro Glu Ser
             500                 505                 510        
 Phe Gly Thr Pro Leu Pro Asp Thr Ile Asp Gln Met Leu Arg Val Lys
         515                 520                 525            
 Gly Met Lys His Arg Lys Thr Pro Ser His Thr Arg Met Leu Lys Asp
     530                 535                 540                
 Gly Gln Glu Arg Pro Thr Ile Leu Lys Ser Thr Ala Phe
 545                 550                 555        



      <210> 2806
      <211> 82
      <212> PRT
      <213> Homo sapiens

      <220>
      <221> misc_feature
      <222> (1)...(82)
      <223> Xaa = any amino acid or symbol as shown in the table 8 as set forth in Example 2


      <400> 2806
 Leu His Ile Glu Lys Ser Asn Glu Ala Ala Asp His Phe Lys His Val
   1               5                  10                  15    
 Ala Cys His Arg Xaa Arg Xaa Ala Cys Thr Cys His Cys Asn Asn Pro
              20                  25                  30        
 Trp Phe Pro Arg Pro Leu Pro Gln Pro Asp Cys Pro Thr Ser Ala Thr
          35                  40                  45            
 Val Glu Pro Pro Leu Tyr Pro Ile Arg Ser Arg Gly Arg Thr Arg Lys
      50                  55                  60                
 Pro Ala Glu Gly Ser Arg Ala Pro Gly Cys Cys Cys Cys Gln Arg Pro
  65                  70                  75                  80
 Gly Lys
        



      <210> 2807
      <211> 406
      <212> PRT
      <213> Homo sapiens


      <400> 2807
 Met Leu Leu Leu Leu Leu Leu Leu Pro Leu Leu Trp Gly Thr Lys Gly
   1               5                  10                  15    
 Met Glu Gly Asp Arg Gln Tyr Gly Asp Gly Tyr Leu Leu Gln Val Gln
              20                  25                  30        
 Glu Leu Val Thr Val Gln Glu Gly Leu Cys Val His Val Pro Cys Ser
          35                  40                  45            
 Phe Ser Tyr Pro Gln Asp Gly Trp Thr Asp Ser Asp Pro Val His Gly
      50                  55                  60                
 Tyr Trp Phe Arg Ala Gly Asp Arg Pro Tyr Gln Asp Ala Pro Val Ala
  65                  70                  75                  80
 Thr Asn Asn Pro Asp Arg Glu Val Gln Ala Glu Thr Gln Gly Arg Phe
                  85                  90                  95    
 Gln Leu Leu Gly Asp Ile Trp Ser Asn Asp Cys Ser Leu Ser Ile Arg
             100                 105                 110        
 Asp Ala Arg Lys Arg Asp Lys Gly Ser Tyr Phe Phe Arg Leu Glu Arg
         115                 120                 125            
 Gly Ser Met Lys Trp Ser Tyr Lys Ser Gln Leu Asn Tyr Lys Thr Lys
     130                 135                 140                
 Gln Leu Ser Val Phe Val Thr Asp Pro Pro Trp Asn Leu Thr Met Thr
 145                 150                 155                 160
 Val Phe Gln Gly Asp Ala Thr Ala Ser Thr Ala Leu Gly Asn Gly Ser
                 165                 170                 175    
 Ser Leu Ser Val Leu Glu Gly Gln Ser Leu Arg Leu Val Cys Ala Val
             180                 185                 190        
 Asn Ser Asn Pro Pro Ala Arg Leu Ser Trp Thr Arg Gly Ser Leu Thr
         195                 200                 205            
 Leu Cys Pro Ser Arg Ser Ser Asn Pro Gly Leu Leu Glu Leu Pro Arg
     210                 215                 220                
 Val His Val Arg Asp Glu Gly Glu Phe Thr Cys Arg Ala Gln Asn Ala
 225                 230                 235                 240
 Gln Gly Ser Gln His Ile Ser Leu Ser Leu Ser Leu Gln Asn Glu Gly
                 245                 250                 255    
 Thr Gly Thr Ser Arg Pro Val Ser Gln Val Thr Leu Ala Ala Val Gly
             260                 265                 270        
 Gly Ala Gly Ala Thr Ala Leu Ala Phe Leu Ser Phe Cys Ile Ile Phe
         275                 280                 285            
 Ile Ile Val Arg Ser Cys Arg Lys Lys Ser Ala Arg Pro Ala Ala Gly
     290                 295                 300                
 Val Gly Asp Thr Gly Met Glu Asp Ala Lys Ala Ile Arg Gly Ser Ala
 305                 310                 315                 320
 Ser Gln Gly Pro Leu Thr Glu Ser Trp Lys Asp Gly Asn Pro Leu Lys
                 325                 330                 335    
 Lys Pro Pro Pro Ala Val Ala Pro Ser Ser Gly Glu Glu Gly Glu Leu
             340                 345                 350        
 His Tyr Ala Thr Leu Ser Phe His Lys Val Lys Pro Gln Asp Pro Gln
         355                 360                 365            
 Gly Gln Glu Ala Thr Asp Ser Glu Tyr Ser Glu Ile Lys Ile His Lys
     370                 375                 380                
 Arg Glu Thr Ala Glu Thr Gln Ala Cys Leu Arg Asn His Asn Pro Ser
 385                 390                 395                 400
 Ser Lys Glu Val Arg Gly
                 405    



      <210> 2808
      <211> 215
      <212> PRT
      <213> Homo sapiens


      <400> 2808
 Arg Ala Leu Asp Leu Ser Val Gln Tyr Pro Pro Glu Asn Leu Arg Val
   1               5                  10                  15    
 Met Val Ser Gln Ala Asn Arg Thr Val Leu Glu Asn Leu Gly Asn Gly
              20                  25                  30        
 Thr Ser Leu Pro Val Leu Glu Gly Gln Ser Leu Cys Leu Val Cys Val
          35                  40                  45            
 Thr His Ser Ser Pro Pro Ala Arg Leu Ser Trp Thr Gln Arg Gly Gln
      50                  55                  60                
 Val Leu Ser Pro Ser Gln Pro Ser Asp Pro Gly Val Leu Glu Leu Pro
  65                  70                  75                  80
 Arg Val Gln Val Glu His Glu Gly Glu Phe Thr Cys His Ala Arg His
                  85                  90                  95    
 Pro Leu Gly Ser Gln His Val Ser Leu Ser Leu Ser Val His Tyr Lys
             100                 105                 110        
 Lys Gly Leu Ile Ser Thr Ala Phe Ser Asn Gly Ala Phe Leu Gly Ile
         115                 120                 125            
 Gly Ile Thr Ala Leu Leu Phe Leu Cys Leu Ala Leu Ile Ile Met Lys
     130                 135                 140                
 Ile Leu Pro Lys Arg Arg Thr Gln Thr Glu Thr Pro Arg Pro Arg Phe
 145                 150                 155                 160
 Ser Arg His Ser Thr Ile Leu Asp Tyr Ile Asn Val Val Pro Thr Ala
                 165                 170                 175    
 Gly Pro Leu Ala Gln Lys Arg Asn Gln Lys Ala Thr Pro Asn Ser Pro
             180                 185                 190        
 Arg Thr Pro Leu Pro Pro Gly Ala Pro Ser Pro Glu Ser Lys Lys Asn
         195                 200                 205            
 Gln Lys Lys Gln Tyr Gln Leu
     210                 215



      <210> 2809
      <211> 100
      <212> PRT
      <213> Homo sapiens


      <400> 2809
 Asn Leu Pro Gly Trp Thr Val Leu Phe Leu Ser Val Leu Gly Leu Leu
   1               5                  10                  15    
 Ala Ser Arg Ala Val Ser Ala Leu Ser Ser Leu Phe Ala Ala Glu Val
              20                  25                  30        
 Phe Pro Thr Val Ile Arg Gly Ala Gly Leu Gly Leu Val Leu Gly Ala
          35                  40                  45            
 Gly Phe Leu Gly Gln Ala Ala Gly Pro Leu Asp Thr Leu His Gly Arg
      50                  55                  60                
 Gln Gly Phe Phe Leu Gln Gln Val Val Phe Ala Ser Leu Ala Val Leu
  65                  70                  75                  80
 Ala Leu Leu Cys Val Leu Leu Leu Pro Glu Ser Arg Ser Arg Gly Leu
                  85                  90                  95    
 Pro Gln Ser Leu
             100



      <210> 2810
      <211> 106
      <212> PRT
      <213> Homo sapiens


      <400> 2810
 Gly Phe Gly Ala Ala Arg Val Arg Ser Leu Phe Lys Glu Ala Arg Ala
   1               5                  10                  15    
 Arg Ala Pro Cys Ile Val Tyr Ile Asp Glu Ile Asp Ala Val Gly Lys
              20                  25                  30        
 Lys Arg Ser Thr Thr Met Ser Gly Phe Ser Asn Thr Glu Glu Glu Gln
          35                  40                  45            
 Thr Leu Asn Gln Leu Leu Val Glu Met Asp Gly Ala Ser Leu Asp Gln
      50                  55                  60                
 Leu Pro Ser Gln Gly Thr Met Arg Lys Leu Arg Gly Lys Thr Pro Ala
  65                  70                  75                  80
 Cys Ser Cys Leu Thr Glu Pro Thr Gly Ser Arg Arg Ala Met Glu Gly
                  85                  90                  95    
 His Ser Leu Cys Trp Gly Cys Leu Leu His
             100                 105    



      <210> 2811
      <211> 123
      <212> PRT
      <213> Homo sapiens


      <400> 2811
 Gly Arg Ser Arg Asn Ser Glu Ser Phe Lys Ala Tyr Ser Gln Val Met
   1               5                  10                  15    
 Glu Asp Glu Glu Lys Ala Val Glu Ile Leu Gly Asn Thr Glu Ala Ala
              20                  25                  30        
 His Pro Pro Ser Pro Ile Arg Cys Cys Trp Leu Arg Leu Arg Cys Leu
          35                  40                  45            
 Ala Ala Thr Ser Ile Ile Cys Gly Cys Ser Cys Leu Gly Val Met Ala
      50                  55                  60                
 Leu Val Phe Ala Ile Lys Ala Glu Glu Arg His Lys Ala Gly Arg Ser
  65                  70                  75                  80
 Glu Glu Ala Val Arg Trp Gly Ala Arg Ala Arg Lys Leu Ile Leu Ala
                  85                  90                  95    
 Ser Phe Ala Val Trp Leu Ala Val Leu Ile Leu Gly Pro Leu Leu Leu
             100                 105                 110        
 Trp Leu Leu Ser Tyr Ala Ile Ala Gln Ala Glu
         115                 120            



      <210> 2812
      <211> 272
      <212> PRT
      <213> Homo sapiens


      <400> 2812
 Ser Ala Ser Phe Arg Asn Ile His Ser Ser Cys Cys Pro Pro Gly Ser
   1               5                  10                  15    
 Arg Arg Cys Ser Ser Ala Ser Ala Ser Ser Arg Thr Arg Ser Ser Trp
              20                  25                  30        
 Thr Ser Pro Thr Ser Gly Ala Ala Gly Pro Ala Lys Ala Pro Ser Trp
          35                  40                  45            
 Gln Gly Ser Pro Pro Gln Ala Gly Ala Gly Thr Trp Ala Thr Gly Pro
      50                  55                  60                
 Ala Ser Pro Pro Pro Pro Ser Pro Leu Pro Pro Gly Arg Leu Leu Gly
  65                  70                  75                  80
 Asn Arg Ser Asn Ser Ser Gly Ala Asp Gly Gly Asp Thr Pro Pro Leu
                  85                  90                  95    
 Pro Ser Pro Pro Asp Lys Gly Asp Asn Ala Ser Asn Cys Asp Cys Arg
             100                 105                 110        
 Ala Trp Asp Tyr Gly Ile Arg Ala Gly Leu Val Gln Asn Val Val Ser
         115                 120                 125            
 Lys Trp Asp Leu Val Cys Asp Asn Ala Trp Lys Val His Ile Ala Lys
     130                 135                 140                
 Phe Ser Leu Leu Val Gly Leu Ile Phe Gly Tyr Leu Ile Thr Gly Cys
 145                 150                 155                 160
 Ile Ala Asp Trp Val Gly Arg Arg Pro Val Leu Leu Phe Ser Ile Ile
                 165                 170                 175    
 Phe Ile Leu Ile Phe Gly Leu Thr Val Ala Leu Ser Val Asn Val Thr
             180                 185                 190        
 Met Phe Ser Thr Leu Arg Phe Phe Glu Gly Phe Cys Leu Ala Gly Ile
         195                 200                 205            
 Ile Leu Thr Leu Tyr Ala Leu Arg Ile Glu Leu Cys Pro Pro Gly Lys
     210                 215                 220                
 Arg Phe Met Ile Thr Met Val Ala Ser Phe Val Ala Met Ala Gly Gln
 225                 230                 235                 240
 Phe Leu Met Pro Gly Leu Ala Ala Leu Cys Arg Asp Trp Gln Val Leu
                 245                 250                 255    
 Gln Ala Leu Ile Ile Cys Pro Phe Leu Leu Met Leu Leu Tyr Trp Ser
             260                 265                 270        





      <210> 2813
      <211> 137
      <212> PRT
      <213> Homo sapiens


      <400> 2813
 Glu Phe Leu Ser Ser Asn Gln Ile Thr Gln Leu Pro Asn Thr Thr Phe
   1               5                  10                  15    
 Arg Pro Met Pro Asn Leu Arg Ser Val Asp Leu Ser Tyr Asn Lys Leu
              20                  25                  30        
 Gln Ala Leu Ala Pro Asp Leu Phe His Gly Leu Arg Lys Leu Thr Thr
          35                  40                  45            
 Leu His Met Arg Ala Asn Ala Ile Gln Phe Val Pro Val Arg Ile Phe
      50                  55                  60                
 Gln Asp Cys Arg Ser Leu Lys Phe Leu Asp Ile Gly Tyr Asn Gln Leu
  65                  70                  75                  80
 Lys Ser Leu Ala Arg Asn Ser Phe Ala Gly Leu Phe Lys Leu Thr Glu
                  85                  90                  95    
 Leu His Leu Glu His Asn Asp Leu Val Lys Val Asn Phe Ala His Phe
             100                 105                 110        
 Pro Arg Leu Ile Ser Leu His Ser Leu Cys Leu Arg Arg Asn Lys Val
         115                 120                 125            
 Ala Ile Val Val Ser Ser Leu Asp Trp
     130                 135        



      <210> 2814
      <211> 229
      <212> PRT
      <213> Homo sapiens

      <220>
      <221> misc_feature
      <222> (1)...(229)
      <223> Xaa = any amino acid or symbol as shown in the table 8 as set forth in Example 2


      <400> 2814
 Phe Ser Ala Glu Gly Pro Ser Leu Glu Pro Cys Ala Leu Asn Ala Gly
   1               5                  10                  15    
 Arg Pro Ala Gln Val Ser Ser Tyr Met Ala Thr Val Ser Gly Leu Leu
              20                  25                  30        
 Lys Ile Val Gln Ala Phe Val Ala Cys Ile Ile Phe Gly Ala Leu Val
          35                  40                  45            
 His Asp Ser Arg Tyr Gly Arg Tyr Val Ala Thr Gln Trp Cys Val Ala
      50                  55                  60                
 Val Tyr Ser Leu Cys Phe Leu Ala Thr Val Ala Val Val Ala Leu Ser
  65                  70                  75                  80
 Val Met Gly His Thr Gly Gly Leu Gly Cys Pro Phe Asp Arg Leu Val
                  85                  90                  95    
 Val Gly Thr Pro Ser Trp Leu Cys Ser Cys Thr Ser Ala Pro Pro Xaa
             100                 105                 110        
 Ser Gly Gln Ser Ser Val Ser Ile Pro Ser Thr Val Ser Pro Asn Gly
         115                 120                 125            
 Pro Pro Thr Val Leu Gly Ala Ala Val Pro Gly Thr Ala Ser Trp Trp
     130                 135                 140                
 Trp Pro Ser Ser Pro Thr Ser Thr Cys Ser Cys Thr Ser Leu Thr Ser
 145                 150                 155                 160
 Pro Thr Pro Arg Gly Phe Ala Ser Cys Pro Ala Cys Ser Pro Gln Trp
                 165                 170                 175    
 Gln Pro Thr His Leu Cys Ser Leu Ala Thr Ser Ser Arg Phe Cys Glu
             180                 185                 190        
 Gly Asn Ser Gly Glu Pro Lys Cys Gln Val Ala Ser Arg Arg Glu Ala
         195                 200                 205            
 Ala Gly Ser Gly Glu Met Lys Tyr Asn Gly Arg Gly Arg Ser Pro Thr
     210                 215                 220                
 Ser Arg Leu Gly Ser
 225                



      <210> 2815
      <211> 74
      <212> PRT
      <213> Homo sapiens


      <400> 2815
 Met Gly Arg Val Ser Gly Leu Val Pro Ser Arg Phe Leu Thr Leu Leu
   1               5                  10                  15    
 Ala His Leu Val Val Val Ile Thr Leu Phe Trp Ser Arg Asp Ser Asn
              20                  25                  30        
 Ile Gln Ala Cys Leu Pro Leu Thr Phe Thr Pro Glu Glu Tyr Asp Lys
          35                  40                  45            
 Gln Asp Ile His Ala Leu Pro Ala Val Thr Glu Met Ala Leu Phe Val
      50                  55                  60                
 Thr Val Phe Gly Leu Lys Lys Lys Pro Phe
  65                  70                



      <210> 2816
      <211> 117
      <212> PRT
      <213> Homo sapiens


      <400> 2816
 Val Gly Glu Arg Leu Thr Leu Pro Gly Leu Val Ser Ala Asp Asn Gly
   1               5                  10                  15    
 Thr Tyr Thr Cys Glu Ala Ser Asn Lys His Gly His Ala Arg Ala Leu
              20                  25                  30        
 Tyr Val Leu Val Val Tyr Asp Pro Gly Ala Val Val Glu Ala Gln Thr
          35                  40                  45            
 Ser Val Pro Tyr Ala Ile Val Gly Gly Ile Leu Ala Leu Leu Val Phe
      50                  55                  60                
 Leu Ile Ile Cys Val Leu Val Gly Met Val Trp Cys Ser Val Arg Gln
  65                  70                  75                  80
 Lys Gly Ser Tyr Leu Thr His Glu Ala Ser Gly Leu Asp Glu Gln Gly
                  85                  90                  95    
 Glu Ala Arg Glu Ala Phe Leu Asn Gly Ser Asp Gly His Lys Arg Lys
             100                 105                 110        
 Glu Glu Phe Phe Ile
         115        



      <210> 2817
      <211> 532
      <212> PRT
      <213> Homo sapiens


      <400> 2817
 Arg Arg Arg Pro Arg Leu Leu Pro Gly Ala Glu Pro Cys Glu Pro Arg
   1               5                  10                  15    
 Val Gly Pro Arg Arg Ala Asp Met Gly Cys Ser Ala Lys Ala Arg Trp
              20                  25                  30        
 Ala Ala Gly Ala Leu Gly Val Ala Gly Leu Leu Cys Ala Val Leu Gly
          35                  40                  45            
 Ala Val Met Ile Val Met Val Pro Ser Leu Ile Lys Gln Gln Val Leu
      50                  55                  60                
 Lys Asn Val Arg Ile Asp Pro Ser Ser Leu Ser Phe Asn Met Trp Lys
  65                  70                  75                  80
 Glu Ile Pro Ile Pro Phe Tyr Leu Ser Val Tyr Phe Phe Asp Val Met
                  85                  90                  95    
 Asn Pro Ser Glu Ile Leu Lys Gly Glu Lys Pro Gln Val Arg Glu Arg
             100                 105                 110        
 Gly Pro Tyr Val Tyr Arg Glu Phe Arg His Lys Ser Asn Ile Thr Phe
         115                 120                 125            
 Asn Asn Asn Asp Thr Val Ser Phe Leu Glu Tyr Arg Thr Phe Gln Phe
     130                 135                 140                
 Gln Pro Ser Lys Ser His Gly Ser Glu Ser Asp Tyr Ile Val Met Pro
 145                 150                 155                 160
 Asn Ile Leu Val Leu Gly Ala Ala Val Met Met Glu Asn Lys Pro Met
                 165                 170                 175    
 Thr Leu Lys Leu Ile Met Thr Leu Ala Phe Thr Thr Leu Gly Glu Arg
             180                 185                 190        
 Ala Phe Met Asn Arg Thr Val Gly Glu Ile Met Trp Gly Tyr Lys Asp
         195                 200                 205            
 Pro Leu Val Asn Leu Ile Asn Lys Tyr Phe Pro Gly Met Phe Pro Phe
     210                 215                 220                
 Lys Asp Lys Phe Gly Leu Phe Ala Glu Leu Asn Asn Ser Asp Ser Gly
 225                 230                 235                 240
 Leu Phe Thr Gly Phe Thr Gly Val Gln Asn Ile Ser Arg Ile His Leu
                 245                 250                 255    
 Val Asp Lys Trp Asn Gly Leu Ser Lys Val Asp Phe Trp His Ser Asp
             260                 265                 270        
 Gln Cys Asn Met Ile Asn Gly Thr Ser Gly Gln Met Trp Pro Pro Phe
         275                 280                 285            
 Met Thr Pro Glu Ser Ser Leu Glu Phe Tyr Ser Pro Glu Ala Cys Arg
     290                 295                 300                
 Ser Met Lys Leu Met Tyr Lys Glu Ser Gly Val Phe Glu Gly Ile Pro
 305                 310                 315                 320
 Thr Tyr Arg Phe Val Ala Pro Lys Thr Leu Phe Ala Asn Gly Ser Ile
                 325                 330                 335    
 Tyr Pro Pro Asn Glu Gly Phe Cys Pro Cys Leu Glu Ser Gly Ile Gln
             340                 345                 350        
 Asn Val Ser Thr Cys Arg Phe Ser Ala Pro Leu Phe Leu Ser His Pro
         355                 360                 365            
 His Phe Leu Asn Ala Asp Pro Val Leu Ala Glu Ala Val Thr Gly Leu
     370                 375                 380                
 His Pro Asn Gln Glu Ala His Ser Leu Phe Leu Asp Ile His Pro Val
 385                 390                 395                 400
 Thr Gly Ile Pro Met Asn Cys Ser Val Lys Leu Gln Leu Ser Leu Tyr
                 405                 410                 415    
 Met Lys Ser Val Ala Gly Ile Gly Gln Thr Gly Lys Ile Glu Pro Val
             420                 425                 430        
 Val Leu Pro Leu Leu Trp Phe Ala Glu Ser Gly Ala Met Glu Gly Glu
         435                 440                 445            
 Thr Leu His Thr Phe Tyr Thr Gln Leu Val Leu Met Pro Lys Val Met
     450                 455                 460                
 His Tyr Ala Gln Tyr Val Leu Leu Ala Leu Gly Cys Val Leu Leu Leu
 465                 470                 475                 480
 Val Pro Val Ile Cys Gln Ile Arg Ser Gln Glu Lys Cys Tyr Leu Phe
                 485                 490                 495    
 Trp Ser Ser Ser Lys Lys Gly Ser Lys Asp Lys Glu Ala Ile Gln Ala
             500                 505                 510        
 Tyr Ser Glu Ser Leu Met Thr Ser Ala Pro Lys Gly Ser Val Leu Gln
         515                 520                 525            
 Glu Ala Lys Leu
     530        



      <210> 2818
      <211> 157
      <212> PRT
      <213> Homo sapiens


      <400> 2818
 Thr Gly Pro Thr Ile Lys Asn Met Asp Gly Thr Phe Asn Val Thr Ser
   1               5                  10                  15    
 Cys Leu Lys Leu Asn Ser Ser Gln Glu Asp Pro Gly Thr Val Tyr Gln
              20                  25                  30        
 Cys Val Val Arg His Ala Ser Leu His Thr Pro Leu Arg Ser Asn Phe
          35                  40                  45            
 Thr Leu Thr Ala Ala Arg His Ser Leu Ser Glu Thr Glu Lys Thr Asp
      50                  55                  60                
 Asn Phe Ser Ile His Trp Trp Pro Ile Ser Phe Ile Gly Val Gly Leu
  65                  70                  75                  80
 Val Leu Leu Ile Val Leu Ile Pro Trp Lys Lys Ile Cys Asn Lys Ser
                  85                  90                  95    
 Ser Ser Ala Tyr Thr Pro Leu Lys Cys Ile Leu Lys His Trp Asn Ser
             100                 105                 110        
 Phe Asp Thr Gln Thr Leu Lys Lys Glu His Leu Ile Phe Phe Cys Thr
         115                 120                 125            
 Arg Ala Trp Pro Ser Tyr Gln Leu Gln Asp Gly Glu Ala Trp Pro Pro
     130                 135                 140                
 Glu Gly Ser Val Asn Ile Asn Thr Tyr Ser Thr Thr Val
 145                 150                 155        



      <210> 2819
      <211> 164
      <212> PRT
      <213> Homo sapiens


      <400> 2819
 Lys Ile Lys Ala Lys Asn Leu Thr Asn Tyr Asp Leu Cys Ser Ile Phe
   1               5                  10                  15    
 Leu Gly Thr Ser Thr Leu Leu Val Trp Val Gly Val Ile Arg Tyr Leu
              20                  25                  30        
 Gly Tyr Phe Gln Ala Tyr Asn Val Leu Ile Leu Thr Met Gln Ala Ser
          35                  40                  45            
 Leu Pro Lys Val Leu Arg Phe Cys Ala Cys Ala Gly Met Ile Tyr Leu
      50                  55                  60                
 Gly Tyr Thr Phe Cys Gly Trp Ile Val Leu Gly Pro Tyr His Asp Lys
  65                  70                  75                  80
 Phe Glu Asn Leu Asn Thr Val Ala Glu Cys Leu Phe Ser Leu Val Asn
                  85                  90                  95    
 Gly Asp Asp Met Phe Ala Thr Phe Ala Gln Ile Gln Gln Lys Ser Ile
             100                 105                 110        
 Leu Val Trp Leu Phe Ser Arg Leu Tyr Leu Tyr Ser Phe Ile Ser Leu
         115                 120                 125            
 Phe Ile Tyr Met Ile Leu Ser Leu Phe Ile Ala Leu Ile Thr Asp Ser
     130                 135                 140                
 Tyr Asp Thr Ile Lys Lys Phe Gln Gln Asn Gly Phe Pro Glu Thr Asp
 145                 150                 155                 160
 Leu Gln Glu Phe
                



      <210> 2820
      <211> 89
      <212> PRT
      <213> Homo sapiens


      <400> 2820
 Val Ile Glu Trp Val Val Pro Val Glu Pro Pro Asn Gln Leu Ser Thr
   1               5                  10                  15    
 Ser Ser Val Gly Arg Val Pro Gly Ser Thr Arg Pro Gln Arg Ser Phe
              20                  25                  30        
 Leu Ser Arg Val Val Arg Ala Ala Leu Pro Leu Gln Leu Leu Leu Leu
          35                  40                  45            
 Leu Leu Leu Leu Leu Ala Cys Leu Leu Pro Ser Ser Glu Glu Asp Tyr
      50                  55                  60                
 Ser Cys Thr Gln Ala Asn Asn Phe Ala Arg Ser Phe Tyr Pro Met Leu
  65                  70                  75                  80
 Arg Tyr Thr Asn Gly Pro Pro Pro Thr
                  85                



      <210> 2821
      <211> 109
      <212> PRT
      <213> Homo sapiens


      <400> 2821
 Met Ser Glu Arg His Gly Pro Ser Ser Gln Ser Val Leu Leu Ser Leu
   1               5                  10                  15    
 Trp Phe Val Leu Thr Leu Thr Pro Phe Leu Val Leu Thr Leu Leu Ser
              20                  25                  30        
 Cys Met Glu His Thr Ala Pro Ala Pro Phe Gln Ser Ala Trp Gln Thr
          35                  40                  45            
 Pro Gly Leu Cys Arg Ala Arg Ser Phe Cys Val Pro Phe Arg Ser Ser
      50                  55                  60                
 Leu Cys Cys Arg Gln Ala Ile Glu Gly Glu Gly Arg Pro Trp Gln Pro
  65                  70                  75                  80
 Ser Gly Lys Ser Leu Asp Ser Trp Ser Ser Val Ala Gly Leu Gln Pro
                  85                  90                  95    
 Leu Gly Gly Gly Asn Phe Tyr Leu Thr Lys Lys Trp Asn
             100                 105                



      <210> 2822
      <211> 135
      <212> PRT
      <213> Homo sapiens

      <220>
      <221> misc_feature
      <222> (1)...(135)
      <223> Xaa = any amino acid or symbol as shown in the table 8 as set forth in Example 2


      <400> 2822
 Gly Xaa Ala Gly Val Gly Gly Asp Ser Glu Gly Glu Val Thr Ser Ala
   1               5                  10                  15    
 Leu Ser Ala Thr Phe Ser Gly Pro Lys Ile Ala Phe Tyr Val Gly Leu
              20                  25                  30        
 Lys Ser Pro His Glu Gly Tyr Glu Val Leu Lys Phe Asp Asp Val Val
          35                  40                  45            
 Thr Asn Leu Gly Asn His Tyr Asp Pro Thr Thr Gly Lys Phe Ser Cys
      50                  55                  60                
 Gln Val Arg Gly Ile Tyr Phe Phe Thr Tyr His Ile Leu Met Arg Gly
  65                  70                  75                  80
 Gly Asp Gly Thr Ser Met Trp Ala Asp Leu Cys Lys Asn Gly Gln Val
                  85                  90                  95    
 Arg Ala Ser Ala Ile Ala Gln Asp Ala Asp Gln Asn Tyr Asp Tyr Ala
             100                 105                 110        
 Ser Asn Ser Val Val Leu His Leu Asp Ser Gly Asp Glu Val Tyr Val
         115                 120                 125            
 Lys Leu Asp Gly Gly Lys Ala
     130                 135



      <210> 2823
      <211> 20
      <212> PRT
      <213> Homo sapiens


      <400> 2823
 Pro Pro Gln Lys Ser Asp Pro Pro Tyr Lys Leu Val Pro Val His Leu
   1               5                  10                  15    
 Asp Ser Ile Leu
              20



      <210> 2824
      <211> 94
      <212> PRT
      <213> Homo sapiens


      <400> 2824
 His Ser Gly Val Ile Gly Arg Ser Trp Ala Met Leu Phe Ala Ser Gly
   1               5                  10                  15    
 Gly Phe Gln Val Lys Leu Tyr Asp Ile Glu Gln Gln Gln Ile Arg Asn
              20                  25                  30        
 Ala Leu Glu Asn Ile Arg Trp Ala Ser Arg Arg Ser Pro Glu Gly Met
          35                  40                  45            
 Glu Val Gly Leu Phe Leu Ser Val Gly Leu Val Cys His Ile Leu Lys
      50                  55                  60                
 Ala Met Arg Ile Cys Asp Val Thr Phe Ser Ser Asp Gly Tyr Cys Ser
  65                  70                  75                  80
 Ala Ser Glu Leu Val Lys Ala Arg Pro Thr Val Ala Gly Met
                  85                  90                



      <210> 2825
      <211> 94
      <212> PRT
      <213> Homo sapiens


      <400> 2825
 His Ser Gly Val Ile Gly Arg Ser Trp Ala Met Leu Phe Ala Ser Gly
   1               5                  10                  15    
 Gly Phe Gln Val Lys Leu Tyr Asp Ile Glu Gln Gln Gln Ile Arg Asn
              20                  25                  30        
 Ala Leu Glu Asn Ile Arg Trp Ala Ser Arg Arg Ser Pro Glu Gly Met
          35                  40                  45            
 Glu Val Gly Leu Phe Leu Ser Val Gly Leu Val Cys His Ile Leu Lys
      50                  55                  60                
 Ala Met Arg Ile Cys Asp Val Thr Phe Ser Ser Asp Gly Tyr Cys Ser
  65                  70                  75                  80
 Ala Ser Glu Leu Val Lys Ala Arg Pro Thr Val Ala Gly Met
                  85                  90                



      <210> 2826
      <211> 79
      <212> PRT
      <213> Homo sapiens


      <400> 2826
 Phe Gln Phe Ile Gln Ile Glu Leu Leu Asn Ile Leu Gln Ser Leu Ile
   1               5                  10                  15    
 Arg Asn Gln Thr Gln Ser Pro Tyr Asn Thr Thr Ala Tyr Pro Ala Ile
              20                  25                  30        
 Asp Ser Val Ile Thr Ile Leu Pro Phe Ser Phe Ser Cys Phe Phe Ile
          35                  40                  45            
 Ile Thr Lys Cys Phe Gly Leu Ser Ile Phe Pro Ser Val Ile Phe Phe
      50                  55                  60                
 Leu His Val Tyr Phe Ile Leu Thr Leu Val Val Phe Tyr Cys Cys
  65                  70                  75                



      <210> 2827
      <211> 875
      <212> PRT
      <213> Homo sapiens


      <400> 2827
 Arg Arg Lys Met Ala Gly Cys Arg Gly Ser Leu Cys Cys Cys Cys Arg
   1               5                  10                  15    
 Trp Cys Cys Cys Cys Gly Glu Arg Glu Thr Arg Thr Pro Glu Glu Leu
              20                  25                  30        
 Thr Ile Leu Gly Glu Thr Gln Glu Glu Glu Asp Glu Ile Leu Pro Arg
          35                  40                  45            
 Lys Asp Tyr Glu Ser Leu Asp Tyr Asp Arg Cys Ile Asn Asp Pro Tyr
      50                  55                  60                
 Leu Glu Val Leu Glu Thr Met Asp Asn Lys Lys Gly Arg Arg Tyr Glu
  65                  70                  75                  80
 Ala Val Lys Trp Met Val Val Phe Ala Ile Gly Val Cys Thr Gly Leu
                  85                  90                  95    
 Val Gly Leu Phe Val Asp Phe Phe Val Arg Leu Phe Thr Gln Leu Lys
             100                 105                 110        
 Phe Gly Val Val Gln Thr Ser Val Glu Glu Cys Ser Gln Lys Gly Cys
         115                 120                 125            
 Leu Ala Leu Ser Leu Leu Glu Leu Leu Gly Phe Asn Leu Thr Phe Val
     130                 135                 140                
 Phe Leu Ala Ser Leu Leu Val Leu Ile Glu Pro Val Ala Ala Gly Ser
 145                 150                 155                 160
 Gly Ile Pro Glu Val Lys Cys Tyr Leu Asn Gly Val Lys Val Pro Gly
                 165                 170                 175    
 Ile Val Arg Leu Arg Thr Leu Leu Cys Lys Val Leu Gly Val Leu Phe
             180                 185                 190        
 Ser Val Ala Gly Gly Leu Phe Val Gly Lys Glu Gly Pro Met Ile His
         195                 200                 205            
 Ser Gly Ser Val Val Gly Ala Gly Leu Pro Gln Phe Gln Ser Ile Ser
     210                 215                 220                
 Leu Arg Lys Ile Gln Phe Asn Phe Pro Tyr Phe Arg Ser Asp Arg Tyr
 225                 230                 235                 240
 Gly Lys Asp Lys Arg Asp Phe Val Ser Ala Gly Ala Ala Ala Gly Val
                 245                 250                 255    
 Ala Ala Ala Phe Gly Ala Pro Ile Gly Gly Thr Leu Phe Ser Leu Glu
             260                 265                 270        
 Glu Gly Ser Ser Phe Trp Asn Gln Gly Leu Thr Trp Lys Val Leu Phe
         275                 280                 285            
 Cys Ser Met Ser Ala Thr Phe Thr Leu Asn Phe Phe Arg Ser Gly Ile
     290                 295                 300                
 Gln Phe Gly Ser Trp Gly Ser Phe Gln Leu Pro Gly Leu Leu Asn Phe
 305                 310                 315                 320
 Gly Glu Phe Lys Cys Ser Asp Ser Asp Lys Lys Cys His Leu Trp Thr
                 325                 330                 335    
 Ala Met Asp Leu Gly Phe Phe Val Val Met Gly Val Ile Gly Gly Leu
             340                 345                 350        
 Leu Gly Ala Thr Phe Asn Cys Leu Asn Lys Arg Leu Ala Lys Tyr Arg
         355                 360                 365            
 Met Arg Asn Val His Pro Lys Pro Lys Leu Val Arg Val Leu Glu Ser
     370                 375                 380                
 Leu Leu Val Ser Leu Val Thr Thr Val Val Val Phe Val Ala Ser Met
 385                 390                 395                 400
 Val Leu Gly Glu Cys Arg Gln Met Ser Ser Ser Ser Gln Ile Gly Asn
                 405                 410                 415    
 Asp Ser Phe Gln Leu Gln Val Thr Glu Asp Val Asn Ser Ser Ile Lys
             420                 425                 430        
 Thr Phe Phe Cys Pro Asn Asp Thr Tyr Asn Asp Met Ala Thr Leu Phe
         435                 440                 445            
 Phe Asn Pro Gln Glu Ser Ala Ile Leu Gln Leu Phe His Gln Asp Gly
     450                 455                 460                
 Thr Phe Ser Pro Val Thr Leu Ala Leu Phe Phe Val Leu Tyr Phe Leu
 465                 470                 475                 480
 Leu Ala Cys Trp Thr Tyr Gly Ile Ser Val Pro Ser Gly Leu Phe Val
                 485                 490                 495    
 Pro Ser Leu Leu Cys Gly Ala Ala Phe Gly Arg Leu Val Ala Asn Val
             500                 505                 510        
 Leu Lys Ser Tyr Ile Gly Leu Gly His Ile Tyr Ser Gly Thr Phe Ala
         515                 520                 525            
 Leu Ile Gly Ala Ala Ala Phe Leu Gly Gly Val Val Arg Met Thr Ile
     530                 535                 540                
 Ser Leu Thr Val Ile Leu Ile Glu Ser Thr Asn Glu Ile Thr Tyr Gly
 545                 550                 555                 560
 Leu Pro Ile Met Val Thr Leu Met Val Gly Lys Trp Thr Gly Asp Phe
                 565                 570                 575    
 Phe Asn Lys Gly Ile Tyr Asp Ile His Val Gly Leu Arg Gly Val Pro
             580                 585                 590        
 Leu Leu Glu Trp Glu Thr Glu Val Glu Met Asp Lys Leu Arg Ala Ser
         595                 600                 605            
 Asp Ile Met Glu Pro Asn Leu Thr Tyr Val Tyr Pro His Thr Arg Ile
     610                 615                 620                
 Gln Ser Leu Val Ser Ile Leu Arg Thr Thr Val His His Ala Phe Pro
 625                 630                 635                 640
 Val Val Thr Glu Asn Arg Gly Asn Glu Lys Glu Phe Met Lys Gly Asn
                 645                 650                 655    
 Gln Leu Ile Ser Asn Asn Ile Lys Phe Lys Lys Ser Ser Ile Leu Thr
             660                 665                 670        
 Arg Ala Gly Glu Gln Arg Lys Arg Ser Gln Ser Met Lys Ser Tyr Pro
         675                 680                 685            
 Ser Ser Glu Leu Arg Asn Met Cys Asp Glu His Ile Ala Ser Glu Glu
     690                 695                 700                
 Pro Ala Glu Lys Glu Asp Leu Leu Gln Gln Met Leu Glu Arg Arg Tyr
 705                 710                 715                 720
 Thr Pro Tyr Pro Asn Leu Tyr Pro Asp Gln Ser Pro Ser Glu Asp Trp
                 725                 730                 735    
 Thr Met Glu Glu Arg Phe Arg Pro Leu Thr Phe His Gly Leu Ile Leu
             740                 745                 750        
 Arg Ser Gln Leu Val Thr Leu Leu Val Arg Gly Val Cys Tyr Ser Glu
         755                 760                 765            
 Ser Gln Ser Ser Ala Ser Gln Pro Arg Leu Ser Tyr Ala Glu Met Ala
     770                 775                 780                
 Glu Asp Tyr Pro Arg Tyr Pro Asp Ile His Asp Leu Asp Leu Thr Leu
 785                 790                 795                 800
 Leu Asn Pro Arg Met Ile Val Asp Val Thr Pro Tyr Met Asn Pro Ser
                 805                 810                 815    
 Pro Phe Thr Val Ser Pro Asn Thr His Val Ser Gln Val Phe Asn Leu
             820                 825                 830        
 Phe Arg Thr Met Gly Leu Arg His Leu Pro Val Val Asn Ala Val Gly
         835                 840                 845            
 Glu Ile Val Gly Ile Ile Thr Arg His Asn Leu Thr Tyr Glu Phe Leu
     850                 855                 860                
 Gln Ala Arg Leu Arg Gln His Tyr Gln Thr Ile
 865                 870                 875



      <210> 2828
      <211> 71
      <212> PRT
      <213> Homo sapiens


      <400> 2828
 Met Leu Ser Tyr Ala His Ile Thr Leu Ala Val Leu Arg Ile Pro Ser
   1               5                  10                  15    
 Ala Thr Gly Cys Trp Arg Ala Phe Phe Thr Cys Ala Ser His Leu Thr
              20                  25                  30        
 Val Val Thr Val Phe Tyr Thr Ala Leu Leu Phe Met Tyr Val Arg Pro
          35                  40                  45            
 Gln Ala Ile Asp Ser Arg Ser Ser Asn Lys Leu Ile Ser Val Leu Tyr
      50                  55                  60                
 Thr Val Ile Thr Pro Ser Val
  65                  70    



      <210> 2829
      <211> 134
      <212> PRT
      <213> Homo sapiens


      <400> 2829
 Gly Ser Thr His Ala Ser Gly Ser Pro Pro Gly Glu Ile Val Ser Leu
   1               5                  10                  15    
 Gly Ile Leu Ser Glu Gly Gln Phe Gly Ile Pro Lys Gly Ile Val Phe
              20                  25                  30        
 Ser Met Pro Val Lys Phe Glu Asn Gly Thr Trp Val Val Leu Thr Asp
          35                  40                  45            
 Leu Lys Asp Val Glu Ile Ser Glu Gln Ile Met Thr Arg Met Thr Ser
      50                  55                  60                
 Asp Leu Ile Gln Glu Lys Leu Val Ala Leu Gly Asp Lys Ile His Phe
  65                  70                  75                  80
 Gln Pro Tyr Gln Ser Gly His Lys Asp Leu Val Pro Asp Glu Glu Lys
                  85                  90                  95    
 Asn Leu Ala Met Ser Asp Ala Ala Glu Phe Pro Asn Gln Ile Pro Gln
             100                 105                 110        
 Thr Thr Phe Glu Lys Pro Gln Ser Leu Glu Phe Leu Asn Glu Phe Glu
         115                 120                 125            
 Gly Lys Thr Val Glu Ser
     130                



      <210> 2830
      <211> 556
      <212> PRT
      <213> Homo sapiens


      <400> 2830
 Ala Ala Ala Ala Ala Ala Gly Ala Phe Ala Gly Arg Arg Ala Ala Cys
   1               5                  10                  15    
 Gly Ala Val Leu Leu Thr Glu Leu Leu Glu Arg Ala Ala Phe Tyr Gly
              20                  25                  30        
 Ile Thr Ser Asn Leu Val Leu Phe Leu Asn Gly Ala Pro Phe Cys Trp
          35                  40                  45            
 Glu Gly Ala Gln Ala Ser Glu Ala Leu Leu Leu Phe Met Gly Leu Thr
      50                  55                  60                
 Tyr Leu Gly Ser Pro Phe Gly Gly Trp Leu Ala Asp Ala Arg Leu Gly
  65                  70                  75                  80
 Arg Ala Arg Ala Ile Leu Leu Ser Leu Ala Leu Tyr Leu Leu Gly Met
                  85                  90                  95    
 Leu Ala Phe Pro Leu Leu Ala Ala Pro Ala Thr Arg Ala Ala Leu Cys
             100                 105                 110        
 Gly Ser Ala Arg Leu Leu Asn Cys Thr Ala Pro Gly Pro Asp Ala Ala
         115                 120                 125            
 Ala Arg Cys Cys Ser Pro Ala Thr Phe Ala Gly Leu Val Leu Val Gly
     130                 135                 140                
 Leu Gly Val Ala Thr Val Lys Ala Asn Ile Thr Pro Phe Gly Ala Asp
 145                 150                 155                 160
 Gln Val Lys Asp Arg Gly Pro Glu Ala Thr Arg Arg Phe Phe Asn Trp
                 165                 170                 175    
 Phe Tyr Trp Ser Ile Asn Leu Gly Ala Ile Leu Ser Leu Gly Gly Ile
             180                 185                 190        
 Ala Tyr Ile Gln Gln Asn Val Ser Phe Val Thr Gly Tyr Ala Ile Pro
         195                 200                 205            
 Thr Val Cys Val Gly Leu Ala Phe Val Val Phe Leu Cys Gly Gln Ser
     210                 215                 220                
 Val Phe Ile Thr Lys Pro Pro Asp Gly Ser Ala Phe Thr Asp Met Phe
 225                 230                 235                 240
 Lys Ile Leu Thr Tyr Ser Cys Cys Ser Gln Lys Arg Ser Gly Glu Arg
                 245                 250                 255    
 Gln Ser Asn Gly Glu Gly Ile Gly Val Phe Gln Gln Ser Ser Lys Gln
             260                 265                 270        
 Ser Leu Phe Asp Ser Cys Lys Met Ser His Gly Gly Pro Phe Thr Glu
         275                 280                 285            
 Glu Lys Val Glu Asp Val Lys Ala Leu Val Lys Ile Val Pro Val Phe
     290                 295                 300                
 Leu Ala Leu Ile Pro Tyr Trp Thr Val Tyr Phe Gln Met Gln Thr Thr
 305                 310                 315                 320
 Tyr Val Leu Gln Ser Leu His Leu Arg Ile Pro Glu Ile Ser Asn Ile
                 325                 330                 335    
 Thr Thr Thr Pro His Thr Leu Pro Ala Ala Trp Leu Thr Met Phe Asp
             340                 345                 350        
 Ala Val Leu Ile Leu Leu Leu Ile Pro Leu Lys Asp Lys Leu Val Asp
         355                 360                 365            
 Pro Ile Leu Arg Arg His Gly Leu Leu Pro Ser Ser Leu Lys Arg Ile
     370                 375                 380                
 Ala Val Gly Met Phe Phe Val Met Cys Ser Ala Phe Ala Ala Gly Ile
 385                 390                 395                 400
 Leu Glu Ser Lys Arg Leu Asn Leu Val Lys Glu Lys Thr Ile Asn Gln
                 405                 410                 415    
 Thr Ile Gly Asn Val Val Tyr His Ala Ala Asp Leu Ser Leu Trp Trp
             420                 425                 430        
 Gln Val Pro Gln Tyr Leu Leu Ile Gly Ile Ser Glu Ile Phe Ala Ser
         435                 440                 445            
 Ile Ala Gly Leu Glu Phe Ala Tyr Ser Ala Ala Pro Lys Ser Met Gln
     450                 455                 460                
 Ser Ala Ile Met Gly Leu Phe Phe Phe Phe Ser Gly Val Gly Ser Phe
 465                 470                 475                 480
 Val Gly Ser Gly Leu Leu Ala Leu Val Ser Ile Lys Ala Ile Gly Trp
                 485                 490                 495    
 Met Ser Ser His Thr Asp Phe Gly Asn Ile Asn Gly Cys Tyr Leu Asn
             500                 505                 510        
 Tyr Tyr Phe Phe Leu Leu Ala Ala Ile Gln Gly Ala Thr Leu Leu Leu
         515                 520                 525            
 Phe Leu Ile Ile Ser Val Lys Tyr Asp His His Arg Asp His Gln Arg
     530                 535                 540                
 Ser Arg Ala Asn Gly Val Pro Thr Ser Arg Arg Ala
 545                 550                 555    



      <210> 2831
      <211> 62
      <212> PRT
      <213> Homo sapiens


      <400> 2831
 Met Leu Ala Ala Lys Leu Thr Leu Ile Leu Glu Leu Leu His Leu Leu
   1               5                  10                  15    
 Cys Ser Leu Phe Ile Leu Ile Leu His Thr Val Leu Asp Ser His Phe
              20                  25                  30        
 Gln Ala Ala Ser Leu Asp Ile Val Gln Gln Ser Met Leu Pro Pro Gly
          35                  40                  45            
 Cys Thr Glu His His Gly Val Ala Gly Asn His Asp Asn Gln
      50                  55                  60        



      <210> 2832
      <211> 121
      <212> PRT
      <213> Homo sapiens


      <400> 2832
 Ser Trp Gly Val Trp Tyr Lys Tyr Gln Pro Leu Asp Leu Val Arg Arg
   1               5                  10                  15    
 Tyr Phe Gly Glu Lys Ile Gly Leu Tyr Phe Ala Trp Leu Gly Trp Tyr
              20                  25                  30        
 Thr Gly Met Leu Phe Pro Ala Ala Phe Ile Gly Leu Phe Val Phe Leu
          35                  40                  45            
 Tyr Gly Val Thr Thr Val Asp His Ser Gln Val Ser Lys Glu Val Cys
      50                  55                  60                
 Gln Ala Thr Asp Ile Ile Met Cys Pro Val Cys Asp Lys Tyr Cys Pro
  65                  70                  75                  80
 Phe Met Arg Leu Ser Asp Ser Cys Val Tyr Ala Lys Val Thr His Leu
                  85                  90                  95    
 Phe Asp Asn Gly Ala Thr Val Phe Ser Ala Val Phe Met Ala Val Trp
             100                 105                 110        
 Ala Thr Val Leu Met Glu Phe Gly Lys
         115                 120    



      <210> 2833
      <211> 155
      <212> PRT
      <213> Homo sapiens


      <400> 2833
 Met Lys Trp Lys Thr Gly Val Ala Ile Phe Val Val Val Val Val Tyr
   1               5                  10                  15    
 Leu Val Thr Gly Gly Leu Val Phe Arg Ala Leu Glu Gln Pro Phe Glu
              20                  25                  30        
 Ser Ser Gln Lys Asn Thr Ile Ala Leu Glu Lys Ala Glu Phe Leu Arg
          35                  40                  45            
 Asp His Val Cys Val Ser Pro Gln Glu Leu Glu Thr Leu Ile Gln His
      50                  55                  60                
 Ala Leu Asp Ala Asp Asn Ala Gly Val Ser Pro Ile Gly Asn Ser Ser
  65                  70                  75                  80
 Asn Asn Ser Ser His Trp Asp Leu Gly Ser Ala Phe Phe Phe Ala Gly
                  85                  90                  95    
 Thr Val Ile Thr Thr Ile Gly Tyr Gly Asn Ile Ala Pro Ser Thr Glu
             100                 105                 110        
 Gly Gly Lys Ile Phe Cys Ile Leu Tyr Ala Ile Phe Gly Phe Pro Leu
         115                 120                 125            
 Phe Gly Phe Leu Leu Ala Gly Ile Glu Asp Gln Leu Gly Thr Ile Phe
     130                 135                 140                
 Gly Lys Ser Ile Ala Arg Val Glu Lys Val Phe
 145                 150                 155



      <210> 2834
      <211> 174
      <212> PRT
      <213> Homo sapiens


      <400> 2834
 Cys Trp Leu Leu Ser Ser Leu Pro Gly Thr Gly Ala Pro Ala Gln Gly
   1               5                  10                  15    
 Lys Arg Lys Arg Met Ser Met Leu Thr Glu Trp Val Gln Arg Gln Arg
              20                  25                  30        
 Thr Pro Leu Cys Arg Ile Cys His Lys Gly Gln Tyr Glu Leu Met Pro
          35                  40                  45            
 Gly Leu Ser Val Thr Pro Leu His Arg His Thr Met Leu Trp Asp Ile
      50                  55                  60                
 Thr Gly Ala Trp Lys Ser Pro Trp Ser Ser Tyr Leu Pro Trp Glu Ser
  65                  70                  75                  80
 Cys Pro Ala Ser Lys Glu Gln Pro Gly Gln Pro Ser His His Glu Asp
                  85                  90                  95    
 Arg Lys His Gln His Val Ser His Leu Pro Leu Pro Ser Pro Ile Phe
             100                 105                 110        
 Ser Tyr Pro Gly Ser Ser Leu Gly Lys Met Ser Gln Ala Glu His Ser
         115                 120                 125            
 Ile Gln Asp Thr Gly Ser Ser Pro Gly Ser Arg Ser Met Gly Thr Leu
     130                 135                 140                
 Ile Val Gln Gly Ile Pro Ser Pro Thr Thr Ile His Lys Val Leu Thr
 145                 150                 155                 160
 Asn Trp His Gln Gly Ile Ala Ser Ser Leu Ser Pro Arg Leu
                 165                 170                



      <210> 2835
      <211> 101
      <212> PRT
      <213> Homo sapiens

      <220>
      <221> misc_feature
      <222> (1)...(101)
      <223> Xaa = any amino acid or symbol as shown in the table 8 as set forth in Example 2


      <400> 2835
 Pro Ala Ser Pro Pro Arg Trp Gly Cys Trp Gly Cys Trp Gly Arg Trp
   1               5                  10                  15    
 Asp Cys Phe Ala Ser Arg Ser Pro Trp Ala Arg Ser Xaa Ser Arg Arg
              20                  25                  30        
 Pro Pro Arg Ser Thr Ala Ala Ala Pro Arg Ser Pro Ala Arg Pro Arg
          35                  40                  45            
 Thr Cys Ala Gly Cys Thr Arg Arg Thr Trp Lys Thr Gly Arg Pro Ala
      50                  55                  60                
 Arg Ser Arg Arg Ser Gly Arg Thr Pro Arg Ala Gly Arg Xaa Lys Xaa
  65                  70                  75                  80
 Ser Pro Gly Ser Gly Thr Arg Thr Ser Arg Pro Gly Gly Arg Arg Arg
                  85                  90                  95    
 Pro Ala Gly Ala Arg
             100    



      <210> 2836
      <211> 50
      <212> PRT
      <213> Homo sapiens


      <400> 2836
 Lys Arg Thr Gln Pro Thr Met Lys Phe Leu Val Phe Ala Phe Ile Leu
   1               5                  10                  15    
 Ala Leu Met Val Ser Met Ile Gly Ala Asp Ser Ser Glu Glu Val Ser
              20                  25                  30        
 His Phe His Ser Leu Glu Asn Leu Phe Ser Val Leu Ser Ser Leu His
          35                  40                  45            
 Leu Tyr
      50



      <210> 2837
      <211> 201
      <212> PRT
      <213> Homo sapiens

      <220>
      <221> misc_feature
      <222> (1)...(201)
      <223> Xaa = any amino acid or symbol as shown in the table 8 as set forth in Example 2


      <400> 2837
 Pro Tyr Ser Ile Ser Ile Val Ser Thr Gly Pro Ser Ala Asp Ser Val
   1               5                  10                  15    
 Tyr Thr Lys Val Arg Leu Leu Glu Gly Glu Thr Leu Ser Val Gln Cys
              20                  25                  30        
 Ser Tyr Lys Gly Tyr Lys Asn Arg Val Glu Gly Lys Val Trp Cys Lys
          35                  40                  45            
 Ile Arg Lys Lys Lys Cys Glu Pro Gly Phe Ala Arg Val Trp Val Lys
      50                  55                  60                
 Gly Pro Arg Tyr Leu Leu Gln Asp Asp Ala Gln Ala Lys Val Val Asn
  65                  70                  75                  80
 Ile Thr Met Val Ala Leu Lys Leu Gln Asp Ser Gly Arg Tyr Trp Cys
                  85                  90                  95    
 Met Arg Asn Thr Ser Gly Ile Leu Tyr Pro Leu Met Gly Phe Gln Leu
             100                 105                 110        
 Asp Val Ser Pro Ala Pro Gln Thr Glu Arg Asn Ile Pro Phe Thr His
         115                 120                 125            
 Leu Asp Asn Ile Leu Lys Ser Gly Thr Val Thr Thr Gly Gln Ala Pro
     130                 135                 140                
 Thr Ser Gly Pro Asp Ala Pro Phe Thr Thr Gly Val Met Val Phe Thr
 145                 150                 155                 160
 Pro Gly Leu Ile Thr Leu Pro Arg Pro Xaa Pro Pro Pro Asp Leu Pro
                 165                 170                 175    
 Pro Arg Gln Ala Thr Ala Ser Leu Leu Pro Ala Pro Pro Ala Arg Asp
             180                 185                 190        
 Pro Gly Gly Pro Trp Gly Pro Arg Gln
         195                 200    



      <210> 2838
      <211> 109
      <212> PRT
      <213> Homo sapiens

      <220>
      <221> misc_feature
      <222> (1)...(109)
      <223> Xaa = any amino acid or symbol as shown in the table 8 as set forth in Example 2


      <400> 2838
 Pro Trp Asp Ser Gly Arg Pro Ser Pro Phe Phe Ser Ala Ala Ser Pro
   1               5                  10                  15    
 Gln Pro Pro Pro Arg Ala Arg Ser Ser Ser Ala Thr Leu Ser Ser Gly
              20                  25                  30        
 Ala Pro Arg Arg Ala Ala Thr Pro Gln Pro Gln Thr Thr Pro Pro Ser
          35                  40                  45            
 Ser Val Gln Pro Cys Ala Ala Thr Pro Cys Ala Arg Gly Gly Arg Pro
      50                  55                  60                
 Ala Pro Ala Gly Val Thr Trp Pro Thr Thr Arg Pro Ser Met Ala Xaa
  65                  70                  75                  80
 Arg Thr Ser Xaa Ala Ser Thr Thr Ala Ser Arg Met Ala Pro Pro Cys
                  85                  90                  95    
 Arg His Ala Cys Ala Arg Phe His Arg Pro Glu Thr Ala
             100                 105                



      <210> 2839
      <211> 205
      <212> PRT
      <213> Homo sapiens

      <220>
      <221> misc_feature
      <222> (1)...(205)
      <223> Xaa = any amino acid or symbol as shown in the table 8 as set forth in Example 2


      <400> 2839
 Ser Gln Val Gly Lys Gly Lys Thr Val Cys Asn Ile Leu Leu Leu Val
   1               5                  10                  15    
 Gly Gly Glu Leu Cys Leu Thr Ser Tyr Ala Pro Pro Ser Ile His Pro
              20                  25                  30        
 Ile Leu Arg Ser Glu Ala Glu Cys Leu Asn Tyr Ser Ile Phe Ser Lys
          35                  40                  45            
 Phe Leu Ala Pro Ala Gly Glu Phe Ala Leu Pro Arg Ser Phe Asp Asn
      50                  55                  60                
 Cys Pro Arg Val Arg Leu Arg Ala Leu Arg Leu Ala Leu Leu Ile Leu
  65                  70                  75                  80
 Leu Thr Phe Ile Leu Cys Trp Thr Pro Tyr Tyr Leu Leu Gly Met Trp
                  85                  90                  95    
 Tyr Trp Phe Ser Pro Thr Met Leu Thr Glu Val Pro Pro Ser Leu Ser
             100                 105                 110        
 His Ile Leu Phe Leu Leu Gly Leu Leu Asn Ala Pro Leu Asp Pro Leu
         115                 120                 125            
 Leu Tyr Gly Ala Phe Thr Leu Gly Cys Arg Arg Gly His Gln Glu Leu
     130                 135                 140                
 Ser Ile Asp Ser Ser Lys Glu Gly Ser Gly Arg Met Leu Gln Glu Glu
 145                 150                 155                 160
 Ile His Ala Phe Arg Gln Leu Glu Val Gln Lys Thr Val Thr Ser Arg
                 165                 170                 175    
 Arg Ala Gly Glu Thr Lys Gly Ile Ser Ile Thr Ser Ile Xaa Ser Xaa
             180                 185                 190        
 Gln Ser Met Xaa Glu Gln Asn Ser Lys Ser Leu Val Pro
         195                 200                 205



      <210> 2840
      <211> 86
      <212> PRT
      <213> Homo sapiens

      <220>
      <221> misc_feature
      <222> (1)...(86)
      <223> Xaa = any amino acid or symbol as shown in the table 8 as set forth in Example 2


      <400> 2840
 Ser Ser Ser Gln Met Gln Val Lys Thr Gln Asp Glu Glu Met Ser Gly
   1               5                  10                  15    
 Gln Lys Thr Arg Lys Pro Arg Ser Ala Pro Gly Thr Thr Glu Arg Ser
              20                  25                  30        
 Xaa Leu Ala Ala Pro Thr Pro Gly Leu Pro Ala Pro Asp Ser Ala Glu
          35                  40                  45            
 Ala Arg Lys Ala Pro Ala Pro Pro Pro Gly Pro Ala Ala Pro Pro Gln
      50                  55                  60                
 Pro Ala Gly Pro Ala Pro Arg Ser Leu Thr His Leu Gly Gly Pro Xaa
  65                  70                  75                  80
 Lys Ser Thr Pro Ser Arg
                  85    



      <210> 2841
      <211> 62
      <212> PRT
      <213> Homo sapiens

      <220>
      <221> misc_feature
      <222> (1)...(62)
      <223> Xaa = any amino acid or symbol as shown in the table 8 as set forth in Example 2


      <400> 2841
 Gly Ala Ala Thr Gly Glu Gly Gly Cys Cys Arg Leu Pro Gly His Pro
   1               5                  10                  15    
 Ala Leu Ala Ser Thr Ala Xaa Ala Ile Pro Cys Arg Gly Pro Arg Val
              20                  25                  30        
 Gln Glu Thr Ser Pro Pro Pro Val Leu Gly Trp Asp Pro Gly Ser Arg
          35                  40                  45            
 Ala Met Ser Arg Ala Leu Val Phe Ala Trp Val Gly Ala Gly
      50                  55                  60        



      <210> 2842
      <211> 174
      <212> PRT
      <213> Homo sapiens


      <400> 2842
 Gly Arg Gly Leu Leu Ala Leu Thr Phe Cys Leu Leu Ala Ala Arg Gly
   1               5                  10                  15    
 Glu Leu Leu Leu Pro Gln Glu Thr Thr Val Glu Leu Ser Cys Gly Val
              20                  25                  30        
 Gly Pro Leu Gln Val Ile Leu Gly Pro Glu Gln Ala Ala Val Leu Asn
          35                  40                  45            
 Cys Ser Leu Gly Ala Ala Ala Ala Gly Pro Pro Thr Arg Val Thr Trp
      50                  55                  60                
 Ser Lys Asp Gly Asp Thr Leu Leu Glu His Asp His Leu His Leu Leu
  65                  70                  75                  80
 Pro Asn Gly Ser Leu Trp Leu Ser Gln Pro Leu Ala Pro Asn Gly Ser
                  85                  90                  95    
 Asp Glu Ser Val Pro Glu Ala Val Gly Val Ile Glu Gly Asn Tyr Ser
             100                 105                 110        
 Cys Leu Ala His Gly Pro Leu Gly Val Leu Ala Ser Gln Thr Ala Val
         115                 120                 125            
 Val Lys Leu Ala Thr Leu Ala Asp Phe Ser Leu His Pro Glu Ser Gln
     130                 135                 140                
 Thr Val Glu Glu Asn Gly Thr Ala Arg Phe Glu Cys His Ile Glu Gly
 145                 150                 155                 160
 Leu Pro Ala Pro Ile Ile Thr Trp Glu Lys Asp Gln Val Thr
                 165                 170                



      <210> 2843
      <211> 109
      <212> PRT
      <213> Homo sapiens


      <400> 2843
 Pro Thr Arg Pro Met Leu Phe Ala Ser Val Ala Leu Arg Tyr Ala Phe
   1               5                  10                  15    
 Pro Cys Gln Val Tyr Ala Glu Lys Lys Glu Asn Ser Pro Ala Pro Pro
              20                  25                  30        
 Ala Pro Met Gln Ser Ile Ser Ser Gly Ile Arg Glu Thr Val Ser Pro
          35                  40                  45            
 Gln Asp Ile Glu Gln Asp Ala Ile His Asn Phe Ser Pro Ala Tyr Gln
      50                  55                  60                
 His Tyr Thr Gln Gln Ala Thr His Glu Ala Pro Arg Pro Gly Thr His
  65                  70                  75                  80
 Pro Ser Gly Gly Ser Gly Gly Ser Arg Lys Ser Arg Ser Leu Glu Lys
                  85                  90                  95    
 Arg Met Leu Ile Pro Ser Glu Asp Leu Gly Gly Gly Leu
             100                 105                



      <210> 2844
      <211> 117
      <212> PRT
      <213> Homo sapiens


      <400> 2844
 Met Leu Val Thr Asp Thr Glu Ala Phe Trp Gln Pro Gln Pro Trp Phe
   1               5                  10                  15    
 Val Val Val Leu Thr Ala Thr Gly Ala Leu Leu Leu Leu Ala Leu Gly
              20                  25                  30        
 Trp Leu Leu Gly Arg Leu Leu Gln Gly Leu Ala Gln Leu Leu Gln Ala
          35                  40                  45            
 Pro Ser Lys Pro Ala Gln Ala Leu Leu Leu Asn Ser Ile Gln Gly Thr
      50                  55                  60                
 Glu Gly Ser Ile Glu Gly Phe Leu Glu Ala Pro Lys Met Glu Met Ser
  65                  70                  75                  80
 Gln Ala Pro Ser Ser Val Met Ser Leu Gln His Phe Asp Gly Arg Thr
                  85                  90                  95    
 Gln Asp Ser Arg Thr Gly Arg Asp Tyr Leu Val Asn Thr His Thr Gly
             100                 105                 110        
 Ala Arg Arg Trp Leu
         115        



      <210> 2845
      <211> 49
      <212> PRT
      <213> Homo sapiens


      <400> 2845
 Met Pro Val Cys Val Leu Gln Leu Asn Asn Cys Leu Gly Ala Tyr Cys
   1               5                  10                  15    
 Val Ile Ser Ser Phe Phe Thr Asn Thr Phe Leu Leu Leu Asn Ala Val
              20                  25                  30        
 Ile Asn Phe Leu Tyr Leu Gly Tyr Leu Gly Phe Ser Glu Ser Pro His
          35                  40                  45            
 Lys
    



      <210> 2846
      <211> 53
      <212> PRT
      <213> Homo sapiens


      <400> 2846
 Met Thr Gln Val His Gln Arg Val Leu Val Cys Thr Val Ala Asp Leu
   1               5                  10                  15    
 Gly Phe Ile Ser Cys Leu Asp Leu Leu His Tyr Gln Gln Ser Glu Ser
              20                  25                  30        
 Leu Arg Ser Pro Gly Gln Glu Ile Ser Glu Ala Ser Leu Ser Phe Trp
          35                  40                  45            
 Ala Phe Leu Thr Ser
      50            



      <210> 2847
      <211> 95
      <212> PRT
      <213> Homo sapiens


      <400> 2847
 Lys Glu Ile Asp Phe Ser Leu Val Asp Val Thr Ala Asp Asp Ala Gly
   1               5                  10                  15    
 Asn Tyr Ser Cys Met Tyr Tyr Gln Thr Lys Ser Pro Phe Trp Ala Ser
              20                  25                  30        
 Glu Pro Ser Asp Gln Leu Glu Ile Leu Val Thr Val Pro Pro Gly Thr
          35                  40                  45            
 Thr Ser Ser Asn Tyr Ser Leu Gly Asn Phe Val Arg Leu Gly Leu Ala
      50                  55                  60                
 Ala Val Ile Val Val Ile Met Gly Ala Phe Leu Val Glu Ala Trp Tyr
  65                  70                  75                  80
 Ser Arg Asn Val Ser Pro Gly Glu Ser Glu Ala Phe Lys Pro Glu
                  85                  90                  95



      <210> 2848
      <211> 81
      <212> PRT
      <213> Homo sapiens


      <400> 2848
 Met Ile Ser Trp Val Leu Leu Phe Ser Leu Leu Cys Leu Ser Val Asn
   1               5                  10                  15    
 Tyr Leu Leu Ala Phe Glu Pro Thr Tyr Val Ala Phe Tyr Tyr Gly Asn
              20                  25                  30        
 Asn Asn Ile Glu Ala Met Tyr Val Phe Thr Tyr Pro Cys Leu Arg Leu
          35                  40                  45            
 Leu Glu Thr Gly Asp Gln Ser Asn Asp Ile His Glu Leu Ala Tyr Met
      50                  55                  60                
 Arg Ile Ser Gly Asp Ser Ser Gly Phe Leu Leu Gly Ala Gln Pro Met
  65                  70                  75                  80
 Gly
    



      <210> 2849
      <211> 260
      <212> PRT
      <213> Homo sapiens


      <400> 2849
 Gln Phe Pro Ala Pro Pro Ser Arg Pro Pro Ser Leu Pro Pro Ser Arg
   1               5                  10                  15    
 Ser Arg Pro Leu Ala Asn Met Ala Leu Val Pro Cys Gln Val Leu Arg
              20                  25                  30        
 Met Ala Ile Leu Leu Ser Tyr Cys Ser Ile Leu Cys Asn Tyr Lys Ala
          35                  40                  45            
 Ile Glu Met Pro Ser His Gln Thr Tyr Gly Gly Ser Trp Lys Phe Leu
      50                  55                  60                
 Thr Phe Ile Asp Leu Val Ile Gln Ala Val Phe Phe Gly Ile Cys Val
  65                  70                  75                  80
 Leu Thr Asp Leu Ser Ser Leu Leu Thr Arg Gly Ser Gly Asn Gln Glu
                  85                  90                  95    
 Gln Glu Arg Gln Leu Lys Lys Leu Ile Ser Leu Arg Asp Trp Met Leu
             100                 105                 110        
 Ala Val Leu Ala Phe Pro Val Gly Val Phe Val Val Ala Val Phe Trp
         115                 120                 125            
 Ile Ile Tyr Ala Tyr Asp Arg Glu Met Ile Tyr Pro Lys Leu Leu Asp
     130                 135                 140                
 Asn Phe Ile Pro Gly Trp Leu Asn His Gly Met His Thr Thr Val Leu
 145                 150                 155                 160
 Pro Phe Ile Leu Ile Glu Met Arg Thr Ser His His Gln Tyr Pro Ser
                 165                 170                 175    
 Arg Ser Ser Gly Leu Thr Ala Ile Cys Thr Phe Ser Val Gly Tyr Ile
             180                 185                 190        
 Leu Trp Val Cys Trp Val His His Val Thr Gly Met Trp Val Tyr Pro
         195                 200                 205            
 Phe Leu Glu His Ile Gly Pro Gly Ala Arg Ile Ile Phe Phe Gly Ser
     210                 215                 220                
 Thr Thr Ile Leu Met Asn Phe Leu Tyr Leu Leu Gly Glu Val Leu Asn
 225                 230                 235                 240
 Asn Tyr Ile Trp Asp Thr Gln Lys Ser Met Glu Glu Glu Lys Glu Lys
                 245                 250                 255    
 Pro Lys Leu Glu
             260



      <210> 2850
      <211> 412
      <212> PRT
      <213> Homo sapiens


      <400> 2850
 Asn Ser Ser Gly Val Lys Leu Leu Gln Ala Leu Gly Leu Ser Pro Gly
   1               5                  10                  15    
 Asn Gly Lys Asp His Ser Ile Leu His Ser Arg Asn Asp Leu Glu Glu
              20                  25                  30        
 Ala Phe Ile His Phe Met Gly Lys Gly Ala Ala Ala Glu Arg Phe Phe
          35                  40                  45            
 Ser Asp Lys Glu Thr Phe His Asp Ile Ala Gln Val Ala Ser Glu Phe
      50                  55                  60                
 Pro Gly Ala Gln His Tyr Val Gly Gly Asn Ala Ala Leu Ile Gly Gln
  65                  70                  75                  80
 Lys Phe Ala Ala Asn Ser Asp Leu Lys Val Leu Leu Cys Gly Pro Val
                  85                  90                  95    
 Gly Pro Lys Leu His Glu Leu Leu Asp Asp Asn Val Phe Val Pro Pro
             100                 105                 110        
 Glu Ser Leu Gln Glu Val Asp Glu Phe His Leu Ile Leu Glu Tyr Gln
         115                 120                 125            
 Ala Gly Glu Glu Trp Gly Gln Leu Lys Ala Pro His Ala Asn Arg Phe
     130                 135                 140                
 Ile Phe Ser His Asp Leu Ser Asn Gly Ala Met Asn Met Leu Glu Val
 145                 150                 155                 160
 Phe Val Ser Ser Leu Glu Glu Phe Gln Pro Asp Leu Gly Gly Leu Ser
                 165                 170                 175    
 Gly Leu His Met Met Glu Gly Gln Ser Lys Glu Leu Gln Arg Lys Arg
             180                 185                 190        
 Leu Leu Glu Val Val Thr Ser Ile Ser Asp Ile Pro Thr Gly Ile Pro
         195                 200                 205            
 Val His Leu Glu Leu Gly Ser Met Thr Asn Arg Glu Leu Met Ser Ser
     210                 215                 220                
 Ile Val Leu Gln Gln Val Phe Pro Ala Val Thr Ser Leu Gly Leu Asn
 225                 230                 235                 240
 Glu Gln Glu Leu Leu Phe Leu Thr Gln Ser Ala Ser Gly Pro His Ser
                 245                 250                 255    
 Ser Leu Ser Ser Trp Asn Gly Val Pro Asp Val Gly Met Val Ser Asp
             260                 265                 270        
 Ile Leu Phe Trp Ile Leu Lys Glu His Gly Arg Ser Lys Ser Arg Ala
         275                 280                 285            
 Ser Asp Leu Thr Arg Ile His Phe His Thr Leu Val Tyr His Ile Leu
     290                 295                 300                
 Ala Thr Val Asp Gly His Trp Ala Asn Gln Leu Ala Ala Val Ala Ala
 305                 310                 315                 320
 Gly Ala Arg Val Ala Gly Thr Gln Ala Cys Ala Thr Glu Thr Ile Asp
                 325                 330                 335    
 Thr Ser Arg Val Ser Leu Arg Ala Pro Gln Glu Phe Met Thr Ser His
             340                 345                 350        
 Ser Glu Ala Gly Ser Arg Ile Val Leu Asn Pro Asn Lys Pro Val Val
         355                 360                 365            
 Glu Trp His Arg Glu Gly Ile Ser Phe His Phe Thr Pro Val Leu Val
     370                 375                 380                
 Cys Lys Asp Pro Ile Arg Thr Val Gly Leu Gly Asp Ala Ile Ser Ala
 385                 390                 395                 400
 Glu Gly Leu Phe Tyr Ser Glu Val His Pro His Tyr
                 405                 410        



      <210> 2851
      <211> 371
      <212> PRT
      <213> Homo sapiens


      <400> 2851
 Pro Arg Val Arg Ser Ser Gly Gly Gln Glu Asp Pro Ala Ser Gln Gln
   1               5                  10                  15    
 Trp Ala Arg Pro Arg Phe Thr Gln Pro Ser Lys Met Arg Arg Arg Val
              20                  25                  30        
 Ile Ala Arg Pro Val Gly Ser Ser Val Arg Leu Lys Cys Val Ala Ser
          35                  40                  45            
 Gly His Pro Arg Pro Asp Ile Thr Trp Met Lys Asp Asp Gln Ala Leu
      50                  55                  60                
 Thr Arg Pro Glu Ala Ala Glu Pro Arg Lys Lys Lys Trp Thr Leu Ser
  65                  70                  75                  80
 Leu Lys Asn Leu Arg Pro Glu Asp Ser Gly Lys Tyr Thr Cys Arg Val
                  85                  90                  95    
 Ser Asn Arg Ala Gly Ala Ile Asn Ala Thr Tyr Lys Val Asp Val Ile
             100                 105                 110        
 Gln Arg Thr Arg Ser Lys Pro Val Leu Thr Gly Thr His Pro Val Asn
         115                 120                 125            
 Thr Thr Val Asp Phe Gly Gly Thr Thr Ser Phe Gln Cys Lys Val Arg
     130                 135                 140                
 Ser Asp Val Lys Pro Val Ile Gln Trp Leu Lys Arg Val Glu Tyr Gly
 145                 150                 155                 160
 Ala Glu Gly Arg His Asn Ser Thr Ile Asp Val Gly Gly Gln Lys Phe
                 165                 170                 175    
 Val Val Leu Pro Thr Gly Asp Val Trp Ser Arg Pro Asp Gly Ser Tyr
             180                 185                 190        
 Leu Asn Lys Leu Leu Ile Thr Arg Ala Arg Gln Asp Asp Ala Gly Met
         195                 200                 205            
 Tyr Ile Cys Leu Gly Ala Asn Thr Met Gly Tyr Ser Phe Arg Ser Ala
     210                 215                 220                
 Phe Leu Thr Val Leu Pro Asp Pro Lys Pro Pro Gly Pro Pro Val Ala
 225                 230                 235                 240
 Ser Ser Ser Ser Ala Thr Ser Leu Pro Trp Pro Val Val Ile Gly Ile
                 245                 250                 255    
 Pro Ala Gly Ala Val Phe Ile Leu Gly Thr Leu Leu Leu Trp Leu Cys
             260                 265                 270        
 Gln Ala Gln Lys Lys Pro Cys Thr Pro Ala Pro Ala Pro Pro Leu Pro
         275                 280                 285            
 Gly His Arg Pro Pro Gly Thr Ala Arg Asp Arg Ser Gly Asp Lys Asp
     290                 295                 300                
 Leu Pro Ser Leu Ala Ala Leu Ser Ala Gly Pro Gly Val Gly Leu Cys
 305                 310                 315                 320
 Glu Glu His Gly Ser Pro Ala Ala Pro Gln His Leu Leu Gly Pro Gly
                 325                 330                 335    
 Pro Val Ala Gly Pro Lys Leu Tyr Pro Lys Leu Tyr Thr Gly His Ser
             340                 345                 350        
 Thr Pro His Thr Tyr Thr His Pro Pro Pro Ser Cys Gln Leu Asn Ser
         355                 360                 365            
 Ser His Ser
     370    



      <210> 2852
      <211> 196
      <212> PRT
      <213> Homo sapiens


      <400> 2852
 Met Arg Thr Leu Leu Thr Ile Leu Thr Val Gly Ser Leu Ala Ala His
   1               5                  10                  15    
 Ala Pro Glu Asp Pro Ser Asp Leu Leu Gln His Val Lys Phe Gln Ser
              20                  25                  30        
 Ser Asn Phe Glu Asn Ile Leu Thr Trp Asp Ser Gly Pro Glu Gly Thr
          35                  40                  45            
 Pro Asp Thr Val Tyr Ser Ile Glu Tyr Lys Thr Tyr Gly Glu Arg Asp
      50                  55                  60                
 Trp Val Ala Lys Lys Gly Cys Gln Arg Ile Thr Arg Lys Ser Cys Asn
  65                  70                  75                  80
 Leu Thr Val Glu Thr Gly Asn Leu Thr Glu Leu Tyr Tyr Ala Arg Val
                  85                  90                  95    
 Thr Ala Val Ser Ala Gly Gly Arg Ser Ala Thr Lys Met Thr Asp Arg
             100                 105                 110        
 Phe Ser Ser Leu Gln His Thr Thr Leu Lys Pro Pro Asp Val Thr Cys
         115                 120                 125            
 Ile Ser Lys Val Arg Ser Ile Gln Met Ile Val His Pro Thr Pro Thr
     130                 135                 140                
 Pro Ile Arg Ala Gly Asp Gly His Arg Leu Thr Leu Glu Asp Ile Phe
 145                 150                 155                 160
 His Asp Leu Phe Tyr His Leu Glu Leu Gln Val Asn Arg Thr Tyr Gln
                 165                 170                 175    
 Met Val Ser Val Cys Cys Thr Leu Val Phe Leu Cys Leu Gly Ser Leu
             180                 185                 190        
 Phe Pro Pro Asn
         195    



      <210> 2853
      <211> 140
      <212> PRT
      <213> Homo sapiens

      <220>
      <221> misc_feature
      <222> (1)...(140)
      <223> Xaa = any amino acid or symbol as shown in the table 8 as set forth in Example 2


      <400> 2853
 Ser Glu Leu Pro Gly Arg Arg Phe Arg Ser Val Thr Asn Leu Cys His
   1               5                  10                  15    
 Glu Ala Trp Val Pro Ala Val Ser Ser Phe Cys Phe Gly Arg Val Ala
              20                  25                  30        
 Phe Ala Gly Tyr Pro Ile Phe Pro Gly Thr Ala Leu Ile Ile Pro Cys
          35                  40                  45            
 Ser Gly Glu Arg Gly Arg Pro Trp Ala Ala His Leu Phe Leu Gly Gly
      50                  55                  60                
 Cys Cys Cys Cys Leu Pro Lys Pro Xaa Cys Leu Cys Pro Phe Ser Gly
  65                  70                  75                  80
 Leu Arg Leu Gly Cys Gln Gly Pro Leu Asp Trp Ser Tyr Leu Gln Leu
                  85                  90                  95    
 Ala Ala Ser Gly Ala Ala Thr Ala Tyr Phe Ser Ser Phe Ser Ala Tyr
             100                 105                 110        
 Cys Val Phe Arg Ile Leu Met Gly Met Thr Phe Ser Gly Ile Ile Leu
         115                 120                 125            
 Asn Ser Val Ser Leu Gly Ser Pro Val Glu Glu Arg
     130                 135                 140



      <210> 2854
      <211> 106
      <212> PRT
      <213> Homo sapiens


      <400> 2854
 Met Tyr Gly Cys Leu Gly Ala Val Ala Trp Cys His Val Thr Thr Val
   1               5                  10                  15    
 Thr Arg Leu Thr Phe Ser Ser Ala Tyr Gln Gly Asn Ser Leu Met Tyr
              20                  25                  30        
 His Asp Ser Pro Cys Ser Asn Gly Tyr Val Tyr Ile Pro Leu Ala Phe
          35                  40                  45            
 Leu Leu Met Leu Tyr Ala Val Tyr Leu Val Glu Cys Trp His Cys Gln
      50                  55                  60                
 Ala Arg His Glu Leu Gln His Arg Val Asp Val Ser Ser Val Arg Glu
  65                  70                  75                  80
 Arg Val Gly Arg Met Gln Gln Ala Thr Pro Cys Ile Trp Trp Lys Glu
                  85                  90                  95    
 His Gln Leu Pro Leu Cys Pro Pro Met Tyr
             100                 105    



      <210> 2855
      <211> 472
      <212> PRT
      <213> Homo sapiens

      <220>
      <221> misc_feature
      <222> (1)...(472)
      <223> Xaa = any amino acid or symbol as shown in the table 8 as set forth in Example 2


      <400> 2855
 Pro Arg Glu Trp Leu Cys Asp Arg His Leu Arg Glu Lys Met Phe Ser
   1               5                  10                  15    
 Ser Val Ala His Leu Ala Arg Ala Asn Pro Phe Asn Thr Pro His Leu
              20                  25                  30        
 Gln Leu Val His Asp Gly Leu Gly Asp Leu Arg Ser Ser Ser Pro Gly
          35                  40                  45            
 Pro Thr Gly Gln Pro Arg Arg Pro Arg Asn Leu Ala Ala Ala Ala Val
      50                  55                  60                
 Glu Glu Gln Tyr Ser Cys Asp Tyr Gly Ser Gly Arg Phe Phe Ile Leu
  65                  70                  75                  80
 Cys Gly Leu Gly Gly Ile Ile Ser Cys Gly Thr Thr His Thr Ala Leu
                  85                  90                  95    
 Val Pro Leu Asp Leu Val Lys Cys Arg Met Gln Val Cys Phe Ala Cys
             100                 105                 110        
 Trp Thr Arg Ala Tyr Xaa Ser Met Thr Asp Cys Xaa Val Ile Arg Tyr
         115                 120                 125            
 Ser His Leu Thr Ser Cys Val Glu Thr Xaa Leu Ser Arg Arg Xaa Val
     130                 135                 140                
 Tyr Asp Gln Xaa His Glu Phe Tyr Ile Lys Met His Gly Val Ser Ser
 145                 150                 155                 160
 Leu Thr Thr Glu Tyr Ser Cys Glu Phe Gly Ser Ala Lys Tyr Tyr Ala
                 165                 170                 175    
 Leu Cys Gly Phe Gly Gly Val Leu Ser Cys Gly Leu Thr His Thr Ala
             180                 185                 190        
 Val Val Pro Leu Asp Leu Val Lys Cys Arg Met Gln Val Asp Pro Gln
         195                 200                 205            
 Lys Tyr Lys Gly Ile Phe Asn Gly Phe Ser Val Thr Leu Lys Glu Asp
     210                 215                 220                
 Gly Val Arg Gly Leu Ala Lys Gly Trp Ala Pro Thr Phe Leu Gly Tyr
 225                 230                 235                 240
 Ser Met Gln Gly Leu Cys Lys Phe Gly Phe Tyr Glu Val Phe Lys Gly
                 245                 250                 255    
 Leu Tyr Ser Asn Met Leu Gly Glu Glu Asn Thr Tyr Leu Trp Arg Thr
             260                 265                 270        
 Ser Leu Tyr Leu Ala Ala Ser Ala Ser Ala Glu Phe Phe Ala Asp Ile
         275                 280                 285            
 Ala Leu Ala Pro Met Glu Ala Ala Lys Val Arg Ile Gln Thr Gln Pro
     290                 295                 300                
 Gly Tyr Ala Asn Thr Leu Arg Asp Ala Ala Pro Lys Met Tyr Lys Glu
 305                 310                 315                 320
 Glu Gly Leu Lys Ala Phe Tyr Lys Gly Val Ala Pro Leu Trp Met Arg
                 325                 330                 335    
 Gln Ile Pro Tyr Thr Met Met Lys Phe Ala Cys Phe Glu Arg Thr Val
             340                 345                 350        
 Glu Ala Leu Tyr Lys Phe Val Val Pro Lys Pro Arg Ser Glu Cys Ser
         355                 360                 365            
 Lys Pro Glu Gln Leu Val Val Thr Phe Val Ala Gly Tyr Ile Ala Gly
     370                 375                 380                
 Val Phe Cys Ala Ile Val Ser His Pro Ala Asp Ser Val Val Ser Val
 385                 390                 395                 400
 Leu Asn Lys Glu Lys Gly Ser Ser Ala Ser Leu Val Leu Lys Arg Leu
                 405                 410                 415    
 Gly Phe Lys Gly Val Trp Lys Gly Leu Phe Ala Arg Ile Ile Met Ile
             420                 425                 430        
 Gly Thr Leu Thr Ala Leu Gln Trp Phe Ile Tyr Asp Ser Val Lys Val
         435                 440                 445            
 Tyr Phe Arg Leu Pro Arg Pro Pro Pro Pro Glu Met Pro Glu Ser Leu
     450                 455                 460                
 Lys Lys Lys Leu Gly Leu Thr Gln
 465                 470        



      <210> 2856
      <211> 353
      <212> PRT
      <213> Homo sapiens


      <400> 2856
 Arg Gly Val Cys Gly Arg Leu Leu Ser Arg Gln Leu His Cys Ala Leu
   1               5                  10                  15    
 Arg Leu Met Ser Lys Val Leu Thr Val Trp Val Cys Val Phe Pro Ala
              20                  25                  30        
 Gly Val Ser Ser Val Thr Ser Leu Met Ser Leu Ala Trp Val Leu Ala
          35                  40                  45            
 Ser Tyr His Lys Leu Leu Arg Asp Ser Arg Asp Asp Lys Lys Ser Met
      50                  55                  60                
 Ser Tyr Arg Gly Ala Ile Ile Gln Val Phe Trp Arg Leu Phe Thr Ile
  65                  70                  75                  80
 Ser Ser Arg Val Ile Ser Phe Ala Leu Phe Ala Ser Ile Phe Gln Leu
                  85                  90                  95    
 Tyr Phe Gly Ile Phe Val Val Val His Trp Cys Ala Met Ala Phe Trp
             100                 105                 110        
 Ile Ile His Gly Gly Thr Asp Phe Cys Met Ser Lys Trp Glu Glu Ile
         115                 120                 125            
 Leu Phe Asn Met Val Val Gly Ile Val Tyr Ile Phe Cys Trp Phe Asn
     130                 135                 140                
 Val Lys Glu Gly Arg Thr Arg Tyr Arg Met Phe Ala Tyr Tyr Thr Ile
 145                 150                 155                 160
 Val Leu Thr Glu Asn Ala Ala Leu Thr Phe Leu Trp Tyr Phe Tyr Arg
                 165                 170                 175    
 Asp Pro Glu Thr Thr Asp Ser Tyr Ala Val Pro Ala Leu Cys Cys Val
             180                 185                 190        
 Phe Ile Ser Phe Val Ala Gly Ile Ala Met Met Leu Leu Tyr Tyr Gly
         195                 200                 205            
 Val Leu His Pro Thr Gly Pro Arg Ala Lys Ile Leu Ala Ser Ser Cys
     210                 215                 220                
 Cys Ala Glu Leu Leu Trp Gly Ile Pro Leu Pro Pro Asp Val Glu Pro
 225                 230                 235                 240
 Met Ala Pro Glu Ile Pro Gly Tyr Arg Gly Thr Gln Val Thr Pro Thr
                 245                 250                 255    
 Arg Ala Val Thr Glu Gln Gln Glu Asp Leu Thr Ala Asp Thr Cys Leu
             260                 265                 270        
 Pro Val Phe Gln Val Arg Pro Met Gly Pro Pro Thr Pro Leu Gly Arg
         275                 280                 285            
 Pro Tyr Leu Pro Glu Gly Pro Leu Ile Lys Ile Asp Met Pro Arg Lys
     290                 295                 300                
 Arg Tyr Pro Ala Trp Asp Ala His Phe Val Asp Arg Arg Leu Arg Arg
 305                 310                 315                 320
 Thr Ile Asn Ile Leu Gln Tyr Val Thr Pro Thr Ala Val Gly Ile Arg
                 325                 330                 335    
 Tyr Arg Asp Gly Pro Leu Leu Tyr Glu Leu Leu Gln Tyr Glu Ser Ser
             340                 345                 350        
 Leu
    



      <210> 2857
      <211> 138
      <212> PRT
      <213> Homo sapiens

      <220>
      <221> misc_feature
      <222> (1)...(138)
      <223> Xaa = any amino acid or symbol as shown in the table 8 as set forth in Example 2


      <400> 2857
 Leu Gly Gly Leu Lys Gly Thr Trp Gly Glu Thr Lys Pro Ala Met Ala
   1               5                  10                  15    
 Ala Ala Glu Glu Glu Asp Gly Gly Pro Glu Gly Pro Asn Arg Glu Arg
              20                  25                  30        
 Gly Gly Ala Gly Ala Thr Lys Thr Leu Leu Tyr Thr Gly Asn His Leu
          35                  40                  45            
 Phe Ser Pro Gln Trp Leu Glu Thr Arg Pro Glu Arg Gln Glu Cys Pro
      50                  55                  60                
 Val Cys Lys Ala Gly Ile Ser Arg Glu Lys Val Val Gly Glu Lys Ser
  65                  70                  75                  80
 Leu Leu Thr Phe Ser Leu His Phe Leu Arg Leu Lys Thr Pro Gln Ile
                  85                  90                  95    
 Cys Arg Leu Pro Val Xaa Leu Phe Leu Pro Pro Xaa Gly Phe Gln Pro
             100                 105                 110        
 Phe Gly Asp Thr Gly Gly Phe His Phe Ser Phe Gly Val Gly Ala Phe
         115                 120                 125            
 Pro Phe Gly Phe Phe Asn Ser Pro Ser Tyr
     130                 135            



      <210> 2858
      <211> 398
      <212> PRT
      <213> Homo sapiens


      <400> 2858
 Gly Arg Gly Gly Trp Cys Leu Pro Arg Ile Met Ala Ala Ser Gly Lys
   1               5                  10                  15    
 Leu Ser Thr Cys Arg Leu Pro Pro Leu Pro Thr Ile Arg Glu Ile Ile
              20                  25                  30        
 Lys Leu Leu Arg Leu Gln Ala Ala Lys Gln Leu Ser Gln Asn Phe Leu
          35                  40                  45            
 Leu Asp Leu Arg Leu Thr Asp Lys Ile Val Arg Lys Ala Gly Asn Leu
      50                  55                  60                
 Thr Asn Ala Tyr Val Tyr Glu Val Gly Pro Gly Pro Gly Gly Ile Thr
  65                  70                  75                  80
 Arg Ser Ile Leu Asn Ala Asp Val Ala Glu Leu Leu Val Val Glu Lys
                  85                  90                  95    
 Asp Thr Arg Phe Ile Pro Gly Leu Gln Met Leu Ser Asp Ala Ala Pro
             100                 105                 110        
 Gly Lys Leu Arg Ile Val His Gly Asp Val Leu Thr Phe Lys Val Glu
         115                 120                 125            
 Lys Ala Phe Ser Glu Ser Leu Lys Arg Pro Trp Glu Asp Asp Pro Pro
     130                 135                 140                
 Asn Val His Ile Ile Gly Asn Leu Pro Phe Ser Val Ser Thr Pro Leu
 145                 150                 155                 160
 Ile Ile Lys Trp Leu Glu Asn Ile Ser Cys Arg Asp Gly Pro Phe Val
                 165                 170                 175    
 Tyr Gly Arg Thr Gln Met Thr Leu Thr Phe Gln Lys Glu Val Ala Glu
             180                 185                 190        
 Arg Leu Ala Ala Asn Thr Gly Ser Lys Gln Arg Ser Arg Leu Ser Val
         195                 200                 205            
 Met Ala Gln Tyr Leu Cys Asn Val Arg His Ile Phe Thr Ile Pro Gly
     210                 215                 220                
 Gln Ala Phe Val Pro Lys Pro Glu Asn Asp Asn Met Phe Ala Tyr Asn
 225                 230                 235                 240
 Glu Val Asp Val Gly Val Val His Phe Thr Pro Leu Ile Gln Pro Lys
                 245                 250                 255    
 Ile Glu Gln Pro Phe Lys Leu Val Glu Lys Val Val Gln Asn Val Phe
             260                 265                 270        
 Gln Phe Arg Arg Lys Tyr Cys His Arg Gly Leu Arg Met Leu Phe Pro
         275                 280                 285            
 Glu Ala Gln Arg Leu Gly Lys His Gly Ala Gly Leu Leu Glu Leu Gly
     290                 295                 300                
 Arg His Arg Pro Leu Leu Leu Arg Pro Arg Gln Leu Ser His Pro His
 305                 310                 315                 320
 Thr Phe Lys Ser Leu Cys Asp Val Tyr Arg Lys Met Cys Asp Glu Asp
                 325                 330                 335    
 Pro Gln Leu Phe Ala Tyr Asn Phe Arg Glu Glu Leu Lys Arg Arg Lys
             340                 345                 350        
 Ser Lys Asn Glu Glu Lys Glu Glu Asp Asp Ala Glu Asn Tyr Arg Leu
         355                 360                 365            
 Ile Ala Ala Ala Trp Gly Arg Ala Ala Tyr Gln Met Ser Ile Cys Thr
     370                 375                 380                
 Thr Trp Ser Phe Leu Tyr Arg Tyr Ser Phe Val Phe Thr Glu
 385                 390                 395            



      <210> 2859
      <211> 230
      <212> PRT
      <213> Homo sapiens


      <400> 2859
 Met Ile Gly Thr Ile Phe Leu Trp Ile Phe Trp Pro Ser Phe Asn Ala
   1               5                  10                  15    
 Ala Leu Thr Ala Leu Gly Ala Gly Gln His Arg Thr Ala Leu Asn Thr
              20                  25                  30        
 Tyr Tyr Ser Leu Ala Ala Ser Thr Leu Gly Thr Phe Ala Leu Ser Ala
          35                  40                  45            
 Leu Val Gly Glu Asp Gly Arg Leu Asp Met Val His Ile Gln Asn Ala
      50                  55                  60                
 Ala Leu Ala Gly Gly Val Val Val Gly Thr Ser Ser Glu Met Met Leu
  65                  70                  75                  80
 Thr Pro Phe Gly Ala Leu Ala Ala Gly Phe Leu Ala Gly Thr Val Ser
                  85                  90                  95    
 Thr Leu Gly Tyr Lys Phe Phe Thr Pro Ile Leu Glu Ser Lys Phe Lys
             100                 105                 110        
 Val Gln Asp Thr Cys Gly Val His Asn Leu His Gly Met Pro Gly Val
         115                 120                 125            
 Leu Gly Ala Leu Leu Gly Val Leu Val Ala Gly Leu Ala Thr His Glu
     130                 135                 140                
 Ala Tyr Gly Asp Gly Leu Glu Ser Val Phe Pro Leu Ile Ala Glu Gly
 145                 150                 155                 160
 Gln Arg Ser Ala Thr Ser Gln Ala Met His Gln Leu Phe Gly Leu Phe
                 165                 170                 175    
 Val Thr Leu Met Phe Ala Ser Val Gly Gly Gly Leu Gly Gly Ile Ile
             180                 185                 190        
 Leu Val Leu Cys Leu Leu Asp Pro Cys Ala Leu Trp His Trp Val Ala
         195                 200                 205            
 Pro Ser Ser Met Val Gly Gly Arg Glu Ala Ser Gln Ile Leu Pro Tyr
     210                 215                 220                
 His His Gln Gly Ser Cys
 225                 230



      <210> 2860
      <211> 624
      <212> PRT
      <213> Homo sapiens


      <400> 2860
 Thr Cys Trp Leu Thr Leu Asp Pro Gln Ser Gln Ser Gly Thr Ser Ala
   1               5                  10                  15    
 Lys Ile His Gln Ser Thr Lys Thr Pro Gly Thr Leu Thr Leu Gly Leu
              20                  25                  30        
 Leu Leu Arg Pro Glu Gly Leu Thr Ser Val Leu Glu Leu Gly Pro Glu
          35                  40                  45            
 Ala Asp Gln Pro Glu Ala Ala Lys Phe Arg Gln Phe Trp Gly Ser Arg
      50                  55                  60                
 Ser Glu Leu Arg Arg Phe Gln Asp Gly Ala Ile Arg Glu Ala Val Val
  65                  70                  75                  80
 Trp Glu Ala Ala Ser Met Ser Gln Lys Arg Leu Ile Pro His Gln Val
                  85                  90                  95    
 Val Thr His Leu Leu Ala Leu His Ala Asp Ile Pro Glu Thr Cys Val
             100                 105                 110        
 His Tyr Val Gly Gly Pro Leu Asp Ala Leu Ile Gln Gly Leu Lys Glu
         115                 120                 125            
 Thr Ser Ser Thr Gly Glu Glu Ala Leu Val Ala Ala Val Arg Cys Tyr
     130                 135                 140                
 Asp Asp Leu Ser Arg Leu Leu Trp Gly Leu Glu Gly Leu Pro Leu Thr
 145                 150                 155                 160
 Val Ser Ala Val Gln Gly Ala His Pro Val Leu Arg Tyr Thr Glu Val
                 165                 170                 175    
 Phe Pro Pro Thr Pro Val Arg Pro Ala Phe Ser Phe Tyr Glu Thr Leu
             180                 185                 190        
 Arg Glu Arg Ser Ser Leu Leu Pro Arg Leu Asp Lys Pro Cys Pro Ala
         195                 200                 205            
 Tyr Val Glu Pro Met Thr Val Val Cys His Leu Glu Gly Ser Gly Gln
     210                 215                 220                
 Trp Pro Gln Asp Ala Glu Ala Val Gln Arg Val Arg Ala Ala Phe Gln
 225                 230                 235                 240
 Leu Arg Leu Ala Glu Leu Leu Thr Gln Gln His Gly Leu Gln Cys Arg
                 245                 250                 255    
 Ala Thr Ala Thr His Thr Asp Val Leu Lys Asp Gly Phe Val Phe Arg
             260                 265                 270        
 Ile Arg Val Ala Tyr Gln Arg Glu Pro Gln Ile Leu Lys Glu Val Gln
         275                 280                 285            
 Ser Pro Glu Gly Met Ile Ser Leu Arg Asp Thr Ala Ala Ser Leu Arg
     290                 295                 300                
 Leu Glu Arg Asp Thr Arg Gln Leu Pro Leu Leu Thr Ser Ala Leu His
 305                 310                 315                 320
 Gly Leu Gln Gln Gln His Pro Ala Phe Ser Gly Val Ala Arg Leu Ala
                 325                 330                 335    
 Lys Arg Trp Val Arg Ala Gln Leu Leu Gly Glu Gly Phe Ala Asp Glu
             340                 345                 350        
 Ser Leu Asp Leu Val Ala Ala Ala Leu Phe Leu His Pro Glu Pro Phe
         355                 360                 365            
 Thr Pro Pro Ser Ser Pro Gln Val Gly Phe Leu Arg Phe Leu Phe Leu
     370                 375                 380                
 Val Ser Thr Phe Asp Trp Lys Asn Asn Pro Leu Phe Val Asn Leu Asn
 385                 390                 395                 400
 Asn Glu Leu Thr Val Glu Glu Gln Val Glu Ile Arg Ser Gly Phe Leu
                 405                 410                 415    
 Ala Ala Arg Ala Gln Leu Pro Val Met Val Ile Val Thr Pro Gln Asp
             420                 425                 430        
 Arg Lys Asn Ser Val Trp Thr Gln Asp Gly Pro Ser Ala Gln Ile Leu
         435                 440                 445            
 Gln Gln Leu Val Val Leu Ala Ala Glu Ala Leu Pro Met Leu Glu Lys
     450                 455                 460                
 Gln Leu Met Asp Pro Arg Gly Pro Gly Asp Ile Arg Thr Val Phe Arg
 465                 470                 475                 480
 Pro Pro Leu Asp Ile Tyr Asp Val Leu Ile Arg Leu Ser Pro Arg His
                 485                 490                 495    
 Ile Pro Arg His Arg Gln Ala Val Asp Ser Pro Ala Ala Ser Phe Cys
             500                 505                 510        
 Arg Gly Leu Leu Ser Gln Pro Gly Pro Ser Ser Leu Met Pro Val Leu
         515                 520                 525            
 Gly Tyr Asp Pro Pro Gln Leu Tyr Leu Thr Gln Leu Arg Glu Ala Phe
     530                 535                 540                
 Gly Asp Leu Ala Leu Phe Phe Tyr Asp Gln His Gly Gly Glu Val Ile
 545                 550                 555                 560
 Gly Val Leu Trp Lys Pro Thr Ser Phe Gln Pro Gln Pro Phe Lys Ala
                 565                 570                 575    
 Ser Ser Thr Lys Gly Arg Met Val Met Ser Arg Gly Gly Glu Leu Val
             580                 585                 590        
 Met Val Pro Asn Val Glu Ala Ile Leu Glu Asp Phe Ala Val Leu Gly
         595                 600                 605            
 Glu Gly Leu Val Gln Thr Val Glu Ala Arg Ser Glu Arg Trp Thr Val
     610                 615                 620                





      <210> 2861
      <211> 176
      <212> PRT
      <213> Homo sapiens

      <220>
      <221> misc_feature
      <222> (1)...(176)
      <223> Xaa = any amino acid or symbol as shown in the table 8 as set forth in Example 2


      <400> 2861
 Arg Phe Cys Leu Cys Val His Leu Ser Arg Phe Trp Pro Ile Phe Asp
   1               5                  10                  15    
 Thr Phe Ile Arg Asp Ser Ile Ser Arg Leu Ser Asn Tyr Pro Glu Pro
              20                  25                  30        
 Pro Pro Ser Ala Leu Val Phe Asp Leu His Val Ser Pro Glu Asp Gly
          35                  40                  45            
 Thr Leu Val Pro Phe Thr Gly Pro Ile Pro Glu Ala Ala Thr Ser Lys
      50                  55                  60                
 Glu Leu Trp Gly Thr Phe Ser Pro Phe Tyr Pro Gly Thr Glu Arg Val
  65                  70                  75                  80
 Phe Val Cys Asp Gly Pro Ala Ser Val Gln Gly Gly Gln Pro Val Leu
                  85                  90                  95    
 Leu Val Gly Arg Arg Gln Gln Gln Gly Lys Ser Ala Phe Val Glu Val
             100                 105                 110        
 Leu Val Glu Pro His His Pro Tyr Ile Tyr Ser Pro His Pro Pro Cys
         115                 120                 125            
 Leu Gln Phe Leu Pro Pro Pro Ser Pro Ala Glu Gln Arg Asn Pro Arg
     130                 135                 140                
 Ala Lys His Lys Pro Ser Pro Gln Pro Trp Ala Ser Pro Gly Phe Xaa
 145                 150                 155                 160
 Thr Leu Pro Pro Leu Leu Ala Gly Gly Pro Ala Pro Ser His Phe Trp
                 165                 170                 175    





      <210> 2862
      <211> 118
      <212> PRT
      <213> Homo sapiens

      <220>
      <221> misc_feature
      <222> (1)...(118)
      <223> Xaa = any amino acid or symbol as shown in the table 8 as set forth in Example 2


      <400> 2862
 Lys Gln Asp Ser Gln Trp Val Ala Ala Ala Pro Ala Ser Val Ala Val
   1               5                  10                  15    
 Ser Thr Cys Trp Arg Gly Leu Pro Leu Pro Trp Ser Gly Gly Gln Asn
              20                  25                  30        
 Arg Gly Lys Gly Ser Leu Pro Leu Gln Val His Arg Gly Ala Xaa Gly
          35                  40                  45            
 Thr Glu Asn Lys Asn Gln Gly Gly Thr Pro Arg Pro Gly Gly Gly Pro
      50                  55                  60                
 Gly Pro Ser Ala Pro Arg Gly Ser Ser Leu Gly Ala His Arg Lys Leu
  65                  70                  75                  80
 Pro Val His His Thr Thr Leu Ser Ser Ser Arg Ser Ala Leu Pro Pro
                  85                  90                  95    
 Thr Pro Arg His Pro Ala Pro Ser Ser Pro Pro Cys Thr Glu Glu Phe
             100                 105                 110        
 His Arg Thr Arg Pro Ile
         115            



      <210> 2863
      <211> 99
      <212> PRT
      <213> Homo sapiens

      <220>
      <221> misc_feature
      <222> (1)...(99)
      <223> Xaa = any amino acid or symbol as shown in the table 8 as set forth in Example 2


      <400> 2863
 Tyr Ser Ile Asp Asp Asn Gln Asn Lys Thr His Asp Lys Lys Glu Lys
   1               5                  10                  15    
 Lys Met Val Val Gln Lys Pro His Gly Thr Met Glu Tyr Thr Ala Gly
              20                  25                  30        
 Asn Gln Asp Thr Leu Asn Ser Ile Ala Leu Lys Phe Asn Ile Thr Pro
          35                  40                  45            
 Asn Lys Leu Val Glu Leu Asn Lys Leu Phe Thr His Thr Ile Val Pro
      50                  55                  60                
 Gly Gln Val Leu Phe Val Pro Asp Ala Asn Ser Pro Ser Ser Thr Leu
  65                  70                  75                  80
 Arg Leu Ser Ser Ser Ser Pro Gly Ala Thr Val Ser Pro Ser Ser Xaa
                  85                  90                  95    
 Asp Ala Glu
            



      <210> 2864
      <211> 127
      <212> PRT
      <213> Homo sapiens


      <400> 2864
 Lys Leu Gly Leu Phe Tyr Glu Tyr Leu Glu Met Ile Ile Gln Phe Gly
   1               5                  10                  15    
 Phe Val Thr Leu Phe Val Ala Ser Phe Pro Leu Ala Pro Leu Leu Ala
              20                  25                  30        
 Leu Val Asn Asn Ile Leu Glu Ile Arg Val Asp Ala Trp Lys Leu Thr
          35                  40                  45            
 Thr Gln Phe Arg Arg Leu Val Pro Glu Lys Ala Gln Asp Ile Gly Ala
      50                  55                  60                
 Trp Gln Pro Ile Met Gln Gly Ile Ala Ile Leu Ala Val Val Thr Asn
  65                  70                  75                  80
 Ala Met Ile Ile Ala Phe Thr Ser Asp Met Ile Pro Arg Leu Val Tyr
                  85                  90                  95    
 Tyr Trp Ser Phe Ser Val Pro Pro Tyr Gly Asp His Thr Ser Tyr Thr
             100                 105                 110        
 Met Glu Gly Tyr Ile Asn Asn Thr Leu Ser Ile Phe Lys Val Ala
         115                 120                 125        



      <210> 2865
      <211> 557
      <212> PRT
      <213> Homo sapiens


      <400> 2865
 Met Arg Asp Tyr Asp Glu Val Thr Ala Phe Leu Gly Glu Trp Gly Pro
   1               5                  10                  15    
 Phe Gln Arg Leu Ile Phe Phe Leu Leu Ser Ala Ser Ile Ile Pro Asn
              20                  25                  30        
 Gly Phe Thr Gly Leu Ser Ser Val Phe Leu Ile Ala Thr Pro Glu His
          35                  40                  45            
 Arg Cys Arg Val Pro Asp Ala Ala Asn Leu Ser Ser Ala Trp Arg Asn
      50                  55                  60                
 His Thr Val Pro Leu Arg Leu Arg Asp Gly Arg Glu Val Pro His Ser
  65                  70                  75                  80
 Cys Arg Arg Tyr Arg Leu Ala Thr Ile Ala Asn Phe Ser Ala Leu Gly
                  85                  90                  95    
 Leu Glu Pro Gly Arg Asp Val Asp Leu Gly Gln Leu Glu Gln Glu Ser
             100                 105                 110        
 Cys Leu Asp Gly Trp Glu Phe Ser Gln Asp Val Tyr Leu Ser Thr Ile
         115                 120                 125            
 Val Thr Glu Trp Asn Leu Val Cys Glu Asp Asp Trp Lys Ala Pro Leu
     130                 135                 140                
 Thr Ile Ser Leu Phe Phe Val Gly Val Leu Leu Gly Ser Phe Ile Ser
 145                 150                 155                 160
 Gly Gln Leu Ser Asp Arg Phe Gly Arg Lys Asn Val Leu Phe Val Thr
                 165                 170                 175    
 Met Gly Met Gln Thr Gly Phe Ser Phe Leu Gln Ile Phe Ser Lys Asn
             180                 185                 190        
 Phe Glu Met Phe Val Val Leu Phe Val Leu Val Gly Met Gly Gln Ile
         195                 200                 205            
 Ser Asn Tyr Val Ala Ala Phe Val Leu Gly Thr Glu Ile Leu Gly Lys
     210                 215                 220                
 Ser Val Arg Ile Ile Phe Ser Thr Leu Gly Val Cys Ile Phe Tyr Ala
 225                 230                 235                 240
 Phe Gly Tyr Met Val Leu Pro Leu Phe Ala Tyr Phe Ile Arg Asp Trp
                 245                 250                 255    
 Arg Met Leu Leu Val Ala Leu Thr Met Pro Gly Val Leu Cys Val Ala
             260                 265                 270        
 Leu Trp Trp Phe Ile Pro Glu Ser Pro Arg Trp Leu Ile Ser Gln Gly
         275                 280                 285            
 Arg Phe Glu Glu Ala Glu Val Ile Ile Arg Lys Ala Ala Lys Ala Asn
     290                 295                 300                
 Gly Ile Val Val Pro Ser Thr Ile Phe Asp Pro Ser Glu Leu Gln Asp
 305                 310                 315                 320
 Leu Ser Ser Lys Lys Gln Gln Ser His Asn Ile Leu Asp Leu Leu Arg
                 325                 330                 335    
 Thr Trp Asn Ile Arg Met Val Thr Ile Met Ser Ile Met Leu Trp Met
             340                 345                 350        
 Thr Ile Ser Val Gly Tyr Phe Gly Leu Ser Leu Asp Thr Pro Asn Leu
         355                 360                 365            
 His Gly Asp Ile Phe Val Asn Cys Phe Leu Ser Ala Met Val Glu Val
     370                 375                 380                
 Pro Ala Tyr Val Leu Ala Trp Leu Leu Leu Gln Tyr Leu Pro Arg Arg
 385                 390                 395                 400
 Tyr Ser Met Ala Thr Ala Leu Phe Leu Gly Gly Ser Val Leu Leu Phe
                 405                 410                 415    
 Met Gln Leu Val Pro Pro Asp Leu Tyr Tyr Leu Ala Thr Val Leu Val
             420                 425                 430        
 Met Val Gly Lys Phe Gly Val Thr Ala Ala Phe Ser Met Val Tyr Val
         435                 440                 445            
 Tyr Thr Ala Glu Leu Tyr Pro Thr Val Val Arg Asn Met Gly Val Gly
     450                 455                 460                
 Val Ser Ser Thr Ala Ser Arg Leu Gly Ser Ile Leu Ser Pro Tyr Phe
 465                 470                 475                 480
 Val Tyr Leu Gly Ala Tyr Asp Arg Phe Leu Pro Tyr Ile Leu Met Gly
                 485                 490                 495    
 Ser Leu Thr Ile Leu Thr Ala Ile Leu Thr Leu Phe Leu Pro Glu Ser
             500                 505                 510        
 Phe Gly Thr Pro Leu Pro Asp Thr Ile Asp Gln Met Leu Arg Val Lys
         515                 520                 525            
 Gly Met Lys His Arg Lys Thr Pro Ser His Thr Arg Met Leu Lys Asp
     530                 535                 540                
 Gly Gln Glu Arg Pro Thr Ile Leu Lys Ser Thr Ala Phe
 545                 550                 555        



      <210> 2866
      <211> 716
      <212> PRT
      <213> Homo sapiens


      <400> 2866
 Met Asp Ile Leu Gly Trp Ala Ser Arg Ala His Lys Trp Lys Gly Arg
   1               5                  10                  15    
 Ala Thr Gly Thr His Val Phe Asn Leu Met Arg Glu Tyr Leu Ile Ser
              20                  25                  30        
 Leu Gln Cys Cys Ala Ser Glu Gln Ala Ala Ser Pro Glu His Gly Ala
          35                  40                  45            
 Ser Phe Arg Val Trp Lys Ser Leu Gly Phe Gln Lys Leu Ile Leu Ser
      50                  55                  60                
 Leu Ile Cys Pro Gln Cys Leu Gln Ser Leu Thr Arg Glu Thr Trp Met
  65                  70                  75                  80
 Arg Phe Lys Ser Lys Lys Thr Lys Gly Pro Asp Leu Arg Leu Val Met
                  85                  90                  95    
 Asp Ala Asn Lys Trp Glu Phe Arg Arg His Ala Leu Arg Pro Ala Leu
             100                 105                 110        
 Thr Phe Pro Asn Glu Gly Gly Asp Leu Gly Val Glu Ala Leu Pro Val
         115                 120                 125            
 Ala Leu Pro Pro Glu Ala His Val Gly Gly Val Val Leu Pro Ala Ala
     130                 135                 140                
 Leu Val Arg Gly Ala His Gly Glu Gln Leu Pro Ala Ile Pro Gly Pro
 145                 150                 155                 160
 Glu Glu Phe Ala Leu Pro Ala Val Gln Ala Arg Ala Ala Arg Pro Glu
                 165                 170                 175    
 Arg Gln Val Val Val Ile Val Val Asn Glu Ala Gly Val Asp Pro Ala
             180                 185                 190        
 Gly Val Glu Gly Leu Ala Pro Val Pro Val Leu Pro Gly Val Arg Leu
         195                 200                 205            
 Glu Ala Thr Ala Pro Lys Gln Pro Pro Arg Leu Pro Ala Arg Leu Arg
     210                 215                 220                
 Ala Pro Leu Pro Ser Gly Arg Lys Leu Asn Ala Lys Cys Pro Arg Leu
 225                 230                 235                 240
 Arg Trp Gly Phe Phe Val Gln Asp Gly Asp Gly Thr Glu Leu Ala Cys
                 245                 250                 255    
 Leu Ser Glu Gly Asp Gly Gly Cys Cys Gln Glu Ala Pro Leu Asp His
             260                 265                 270        
 Arg Pro Arg Arg Leu Arg Gly Leu Ala Gly Ser Ala Gly Ala Arg Glu
         275                 280                 285            
 Ala Arg Glu Pro Arg Leu Arg Pro Gly Asp Trp Gly Asn Arg Ile Ala
     290                 295                 300                
 Arg Val Arg Ala Pro Glu Glu Ala Ala Ala Ala Leu Ser Arg Pro Ala
 305                 310                 315                 320
 Arg Val Ala Ala Ala Leu Ala Lys Thr His Arg Arg Glu His Arg Ala
                 325                 330                 335    
 Arg Ser Gln Lys Leu Val Met Ser Ser Val Gln Gln Gly Lys Leu Thr
             340                 345                 350        
 Thr Arg Lys Asp Ile Tyr Thr Glu Asn Pro Ser Val His His His His
         355                 360                 365            
 Gln Arg Pro Lys Val Asp Lys Thr Thr Lys Met Gly Lys Lys Gln Asn
     370                 375                 380                
 Arg Lys Thr Gly Asn Ser Lys Lys Gln Ser Ala Phe Pro Pro Pro Lys
 385                 390                 395                 400
 Glu Cys Ser Ser Ser Pro Ala Met Glu Gln Thr Trp Thr Asp Asn Asp
                 405                 410                 415    
 Phe Asp Glu Leu Arg Glu Glu Gly Phe Arg Gly Ser Asn Tyr Ser Glu
             420                 425                 430        
 Leu Arg Glu Asp Ile Gln Thr Lys Gly Lys Glu Val Glu Asn Phe Glu
         435                 440                 445            
 Lys Asp Leu Glu Glu Cys Ile Thr Arg Ile Thr Asn Thr Glu Lys Cys
     450                 455                 460                
 Leu Lys Glu Arg Met Glu Leu Lys Thr Lys Ala Arg Glu Leu Arg Glu
 465                 470                 475                 480
 Glu Cys Arg Ser Leu Arg Ser Arg Cys Asp Gln Leu Glu Glu Arg Val
                 485                 490                 495    
 Ser Ala Met Glu Asp Glu Met Asn Glu Met Lys Arg Glu Gly Lys Phe
             500                 505                 510        
 Arg Glu Lys Arg Ile Lys Arg Asn Glu Gln Ser Leu Gln Glu Ile Trp
         515                 520                 525            
 Asp Tyr Val Lys Arg Pro Asn Leu Arg Leu Ile Gly Val Pro Glu Ser
     530                 535                 540                
 Asp Val Glu Asn Gly Thr Lys Leu Glu Asn Thr Leu Gln Asp Ile Ile
 545                 550                 555                 560
 Gln Glu Asn Phe Pro Asn Leu Ala Arg Gln Ala Asn Val Gln Ile Gln
                 565                 570                 575    
 Glu Ile Glu Arg Met Pro Gln Arg Tyr Ser Ser Arg Arg Ala Thr Pro
             580                 585                 590        
 Arg His Ile Ile Val Arg Phe Thr Lys Val Glu Met Lys Glu Lys Met
         595                 600                 605            
 Leu Arg Ala Ala Arg Glu Lys Gly Arg Val Thr Leu Lys Gly Lys Pro
     610                 615                 620                
 Ile Arg Leu Thr Ala Val Leu Ser Ala Glu Thr Leu Gln Ala Arg Arg
 625                 630                 635                 640
 Glu Trp Gly Pro Ile Phe Asn Ile Leu Lys Glu Lys Asn Phe Gln Pro
                 645                 650                 655    
 Arg Ile Ser Tyr Pro Ala Lys Leu Ser Phe Ile Ser Glu Gly Glu Ile
             660                 665                 670        
 Lys Tyr Phe Ile Glu Lys Gln Met Leu Arg Asp Phe Val Thr Thr Arg
         675                 680                 685            
 Pro Ala Leu Lys Glu Leu Leu Lys Glu Ala Leu Asn Met Glu Arg Asn
     690                 695                 700                
 Asn Arg Tyr Gln Pro Leu Gln Asn His Ala Lys Met
 705                 710                 715    



      <210> 2867
      <211> 716
      <212> PRT
      <213> Homo sapiens


      <400> 2867
 Met Asp Ile Leu Gly Trp Ala Ser Arg Ala His Lys Trp Lys Gly Arg
   1               5                  10                  15    
 Ala Thr Gly Thr His Val Phe Asn Leu Met Arg Glu Tyr Leu Ile Ser
              20                  25                  30        
 Leu Gln Cys Cys Ala Ser Glu Gln Ala Ala Ser Pro Glu His Gly Ala
          35                  40                  45            
 Ser Phe Arg Val Trp Lys Ser Leu Gly Phe Gln Lys Leu Ile Leu Ser
      50                  55                  60                
 Leu Ile Cys Pro Gln Cys Leu Gln Ser Leu Thr Arg Glu Thr Trp Met
  65                  70                  75                  80
 Arg Phe Lys Ser Lys Lys Thr Lys Gly Pro Asp Leu Arg Leu Val Met
                  85                  90                  95    
 Asp Ala Asn Lys Trp Glu Phe Arg Arg His Ala Leu Arg Pro Ala Leu
             100                 105                 110        
 Thr Phe Pro Asn Glu Gly Gly Asp Leu Gly Val Glu Ala Leu Pro Val
         115                 120                 125            
 Ala Leu Pro Pro Glu Ala His Val Gly Gly Val Val Leu Pro Ala Ala
     130                 135                 140                
 Leu Val Arg Gly Ala His Gly Glu Gln Leu Pro Ala Ile Pro Gly Pro
 145                 150                 155                 160
 Glu Glu Phe Ala Leu Pro Ala Val Gln Ala Arg Ala Ala Arg Pro Glu
                 165                 170                 175    
 Arg Gln Val Val Val Ile Val Val Asn Glu Ala Gly Val Asp Pro Ala
             180                 185                 190        
 Gly Val Glu Gly Leu Ala Pro Val Pro Val Leu Pro Gly Val Arg Leu
         195                 200                 205            
 Glu Ala Thr Ala Pro Lys Gln Pro Pro Arg Leu Pro Ala Arg Leu Arg
     210                 215                 220                
 Ala Pro Leu Pro Ser Gly Arg Lys Leu Asn Ala Lys Cys Pro Arg Leu
 225                 230                 235                 240
 Arg Trp Gly Phe Phe Val Gln Asp Gly Asp Gly Thr Glu Leu Ala Cys
                 245                 250                 255    
 Leu Ser Glu Gly Asp Gly Gly Cys Cys Gln Glu Ala Pro Leu Asp His
             260                 265                 270        
 Arg Pro Arg Arg Leu Arg Gly Leu Ala Gly Ser Ala Gly Ala Arg Glu
         275                 280                 285            
 Ala Arg Glu Pro Arg Leu Arg Pro Gly Asp Trp Gly Asn Arg Ile Ala
     290                 295                 300                
 Arg Val Arg Ala Pro Glu Glu Ala Ala Ala Ala Leu Ser Arg Pro Ala
 305                 310                 315                 320
 Arg Val Ala Ala Ala Leu Ala Lys Thr His Arg Arg Glu His Arg Ala
                 325                 330                 335    
 Arg Ser Gln Lys Leu Val Met Ser Ser Val Gln Gln Gly Lys Leu Thr
             340                 345                 350        
 Thr Arg Lys Asp Ile Tyr Thr Glu Asn Pro Ser Val His His His His
         355                 360                 365            
 Gln Arg Pro Lys Val Asp Lys Thr Thr Lys Met Gly Lys Lys Gln Asn
     370                 375                 380                
 Arg Lys Thr Gly Asn Ser Lys Lys Gln Ser Ala Phe Pro Pro Pro Lys
 385                 390                 395                 400
 Glu Cys Ser Ser Ser Pro Ala Met Glu Gln Thr Trp Thr Asp Asn Asp
                 405                 410                 415    
 Phe Asp Glu Leu Arg Glu Glu Gly Phe Arg Gly Ser Asn Tyr Ser Glu
             420                 425                 430        
 Leu Arg Glu Asp Ile Gln Thr Lys Gly Lys Glu Val Glu Asn Phe Glu
         435                 440                 445            
 Lys Asp Leu Glu Glu Cys Ile Thr Arg Ile Thr Asn Thr Glu Lys Cys
     450                 455                 460                
 Leu Lys Glu Arg Met Glu Leu Lys Thr Lys Ala Arg Glu Leu Arg Glu
 465                 470                 475                 480
 Glu Cys Arg Ser Leu Arg Ser Arg Cys Asp Gln Leu Glu Glu Arg Val
                 485                 490                 495    
 Ser Ala Met Glu Asp Glu Met Asn Glu Met Lys Arg Glu Gly Lys Phe
             500                 505                 510        
 Arg Glu Lys Arg Ile Lys Arg Asn Glu Gln Ser Leu Gln Glu Ile Trp
         515                 520                 525            
 Asp Tyr Val Lys Arg Pro Asn Leu Arg Leu Ile Gly Val Pro Glu Ser
     530                 535                 540                
 Asp Val Glu Asn Gly Thr Lys Leu Glu Asn Thr Leu Gln Asp Ile Ile
 545                 550                 555                 560
 Gln Glu Asn Phe Pro Asn Leu Ala Arg Gln Ala Asn Val Gln Ile Gln
                 565                 570                 575    
 Glu Ile Glu Arg Met Pro Gln Arg Tyr Ser Ser Arg Arg Ala Thr Pro
             580                 585                 590        
 Arg His Ile Ile Val Arg Phe Thr Lys Val Glu Met Lys Glu Lys Met
         595                 600                 605            
 Leu Arg Ala Ala Arg Glu Lys Gly Arg Val Thr Leu Lys Gly Lys Pro
     610                 615                 620                
 Ile Arg Leu Thr Ala Val Leu Ser Ala Glu Thr Leu Gln Ala Arg Arg
 625                 630                 635                 640
 Glu Trp Gly Pro Ile Phe Asn Ile Leu Lys Glu Lys Asn Phe Gln Pro
                 645                 650                 655    
 Arg Ile Ser Tyr Pro Ala Lys Leu Ser Phe Ile Ser Glu Gly Glu Ile
             660                 665                 670        
 Lys Tyr Phe Ile Glu Lys Gln Met Leu Arg Asp Phe Val Thr Thr Arg
         675                 680                 685            
 Pro Ala Leu Lys Glu Leu Leu Lys Glu Ala Leu Asn Met Glu Arg Asn
     690                 695                 700                
 Asn Arg Tyr Gln Pro Leu Gln Asn His Ala Lys Met
 705                 710                 715    



      <210> 2868
      <211> 148
      <212> PRT
      <213> Homo sapiens


      <400> 2868
 Glu Ile Asp Arg Lys Trp Tyr Tyr Asp Ser Tyr Thr Cys Cys Pro Pro
   1               5                  10                  15    
 Pro Trp Phe Met Ile Thr Val Thr Leu Leu Glu Val Ala Phe Phe Leu
              20                  25                  30        
 Tyr Asn Trp Val Ser Leu Gly Gln Phe Val Leu Gln Val Thr His Pro
          35                  40                  45            
 Arg Tyr Leu Lys Asn Ser Leu Val Tyr His Pro Gln Leu Arg Ala Gln
      50                  55                  60                
 Val Trp Arg Tyr Leu Thr Tyr Ile Phe Met His Ala Gly Ile Glu His
  65                  70                  75                  80
 Leu Gly Leu Asn Val Val Leu Gln Leu Leu Val Gly Val Pro Leu Glu
                  85                  90                  95    
 Met Val His Gly Ala Thr Arg Ile Gly Leu Val Tyr Met Ala Gly Val
             100                 105                 110        
 Val Ala Gly Ser Leu Ala Val Ser Val Ala Asp Met Thr Ala Pro Val
         115                 120                 125            
 Val Gly Ser Ser Gly Gly Val Tyr Ala Leu Val Ser Ala His Leu Ala
     130                 135                 140                
 Asn Ile Val Met
 145            



      <210> 2869
      <211> 145
      <212> PRT
      <213> Homo sapiens


      <400> 2869
 Arg Ser Leu Gln Asp Ala Gln Arg Leu Phe Leu Met Ser Glu Ala Val
   1               5                  10                  15    
 Gln Pro Val Thr Pro Glu Pro Cys Val Thr Gln Asp Ser Val Arg Phe
              20                  25                  30        
 Ser His Leu Val Val Asp Leu Val Gln Ala Lys Asp Thr Leu Tyr His
          35                  40                  45            
 Val Leu Tyr Ile Gly Thr Glu Ser Gly Thr Ile Leu Lys Ala Leu Ser
      50                  55                  60                
 Thr Ala Ser Arg Ser Leu His Gly Cys Tyr Leu Glu Glu Leu His Val
  65                  70                  75                  80
 Leu Pro Pro Gly Arg Arg Glu Pro Leu Arg Ser Leu Arg Ile Leu His
                  85                  90                  95    
 Ser Ala Arg Ala Leu Phe Val Gly Leu Arg Asp Gly Val Leu Arg Val
             100                 105                 110        
 Pro Leu Glu Arg Cys Ala Ala Tyr Arg Ser Gln Gly Ala Cys Leu Gly
         115                 120                 125            
 Ala Arg Asp Pro Tyr Cys Gly Trp Asp Gly Lys Gln Gln Arg Cys Ser
     130                 135                 140                
 Thr
 145



      <210> 2870
      <211> 223
      <212> PRT
      <213> Homo sapiens

      <220>
      <221> misc_feature
      <222> (1)...(223)
      <223> Xaa = any amino acid or symbol as shown in the table 8 as set forth in Example 2


      <400> 2870
 Arg Pro Thr Arg Pro Pro Thr Arg Pro Thr Ala Pro Ile Val Thr Thr
   1               5                  10                  15    
 Pro Val Thr Thr Arg Gly Gly Gly Arg Arg Ser Xaa Arg Ser Ser Ser
              20                  25                  30        
 Gln Ser Pro Lys Ala Pro Ala Pro Gln Pro Pro Pro Ile Leu Lys Val
          35                  40                  45            
 Phe Asn Arg Pro Ile Leu Phe Asp Ile Val Ser Arg Gly Ser Thr Ala
      50                  55                  60                
 Asp Leu Asp Gly Leu Leu Pro Phe Leu Leu Thr His Lys Lys Arg Leu
  65                  70                  75                  80
 Thr Asp Glu Glu Phe Arg Glu Pro Ser Thr Val Lys Thr Cys Leu Pro
                  85                  90                  95    
 Lys Ala Leu Leu Asn Leu Ser Asn Gly Arg Asn Asp Thr Ile Pro Val
             100                 105                 110        
 Leu Leu Asp Ile Ala Glu Arg Thr Gly Asn Met Arg Glu Phe Ile Asn
         115                 120                 125            
 Ser Pro Phe Arg Asp Ile Tyr Tyr Arg Gly Gly Ala Pro Gly Trp Ala
     130                 135                 140                
 Gly Val Pro Arg Gly Leu Met Glu Thr Leu Ser Phe Ala Cys Leu Thr
 145                 150                 155                 160
 Pro Glu Thr Phe Asp Leu Gly Leu Ser Ala Ser Met Tyr Pro Gly Pro
                 165                 170                 175    
 Asp Lys Trp Met Asp Gly Trp Met Asp Gly Trp Met His Gly Cys Met
             180                 185                 190        
 Asp Arg Ser Met Asp Glu Gly Thr Val Thr Thr Pro Ser Asn Phe Val
         195                 200                 205            
 Ser Ser Phe Arg Ile Glu Asp Ser Thr Gly Cys Gly Gly Phe Tyr
     210                 215                 220            



      <210> 2871
      <211> 223
      <212> PRT
      <213> Homo sapiens

      <220>
      <221> misc_feature
      <222> (1)...(223)
      <223> Xaa = any amino acid or symbol as shown in the table 8 as set forth in Example 2


      <400> 2871
 Arg Pro Thr Arg Pro Pro Thr Arg Pro Thr Ala Pro Ile Val Thr Thr
   1               5                  10                  15    
 Pro Val Thr Thr Arg Gly Gly Gly Arg Arg Ser Xaa Arg Ser Ser Ser
              20                  25                  30        
 Gln Ser Pro Lys Ala Pro Ala Pro Gln Pro Pro Pro Ile Leu Lys Val
          35                  40                  45            
 Phe Asn Arg Pro Ile Leu Phe Asp Ile Val Ser Arg Gly Ser Thr Ala
      50                  55                  60                
 Asp Leu Asp Gly Leu Leu Pro Phe Leu Leu Thr His Lys Lys Arg Leu
  65                  70                  75                  80
 Thr Asp Glu Glu Phe Arg Glu Pro Ser Thr Val Lys Thr Cys Leu Pro
                  85                  90                  95    
 Lys Ala Leu Leu Asn Leu Ser Asn Gly Arg Asn Asp Thr Ile Pro Val
             100                 105                 110        
 Leu Leu Asp Ile Ala Glu Arg Thr Gly Asn Met Arg Glu Phe Ile Asn
         115                 120                 125            
 Ser Pro Phe Arg Asp Ile Tyr Tyr Arg Gly Gly Ala Pro Gly Trp Ala
     130                 135                 140                
 Gly Val Pro Arg Gly Leu Met Glu Thr Leu Ser Phe Ala Cys Leu Thr
 145                 150                 155                 160
 Pro Glu Thr Phe Asp Leu Gly Leu Ser Ala Ser Met Tyr Pro Gly Pro
                 165                 170                 175    
 Asp Lys Trp Met Asp Gly Trp Met Asp Gly Trp Met His Gly Cys Met
             180                 185                 190        
 Asp Arg Ser Met Asp Glu Gly Thr Val Thr Thr Pro Ser Asn Phe Val
         195                 200                 205            
 Ser Ser Phe Arg Ile Glu Asp Ser Thr Gly Cys Gly Gly Phe Tyr
     210                 215                 220            



      <210> 2872
      <211> 49
      <212> PRT
      <213> Homo sapiens


      <400> 2872
 Leu Leu Arg Thr Cys Val Asp Phe Phe Arg Leu Val Pro Phe Met Val
   1               5                  10                  15    
 Phe Leu Ile Val Pro Phe Met Glu Phe Leu Leu Pro Val Phe Leu Lys
              20                  25                  30        
 Leu Phe Pro Glu Met Leu Pro Ser Thr Phe Glu Ser Glu Ser Lys Lys
          35                  40                  45            
 Val
    



      <210> 2873
      <211> 142
      <212> PRT
      <213> Homo sapiens


      <400> 2873
 Gly Pro Glu Phe Pro Gly Ser Ala Lys Leu Val Phe Leu Asp Leu Ser
   1               5                  10                  15    
 Tyr Asn Asn Leu Thr Gln Leu Gly Ala Gly Ala Phe Arg Ser Ala Gly
              20                  25                  30        
 Arg Leu Val Lys Leu Ser Leu Ala Asn Asn Asn Leu Val Gly Val His
          35                  40                  45            
 Glu Asp Ala Phe Glu Thr Leu Glu Ser Leu Gln Val Leu Glu Leu Asn
      50                  55                  60                
 Asp Asn Asn Leu Arg Ser Leu Ser Val Ala Ala Leu Ala Ala Leu Pro
  65                  70                  75                  80
 Ala Leu Arg Ser Leu Arg Leu Asp Gly Asn Pro Trp Leu Cys Asp Cys
                  85                  90                  95    
 Asp Phe Ala His Leu Phe Ser Trp Ile Gln Glu Asn Ala Ser Lys Leu
             100                 105                 110        
 Pro Lys Gly Leu Asp Glu Ile Gln Cys Ser Leu Pro Met Glu Ser Arg
         115                 120                 125            
 Arg Ile Ser Leu Arg Ala Cys Arg Arg Pro Ala Ser Arg Val
     130                 135                 140        



      <210> 2874
      <211> 110
      <212> PRT
      <213> Homo sapiens


      <400> 2874
 Met Tyr Ala Leu Tyr Ile Thr Val His Gly Tyr Phe Leu Ile Thr Phe
   1               5                  10                  15    
 Leu Phe Gly Met Val Val Leu Ala Leu Val Val Trp Lys Ile Phe Thr
              20                  25                  30        
 Leu Ser Arg Ala Thr Ala Val Lys Glu Arg Gly Lys Asn Arg Lys Lys
          35                  40                  45            
 Val Leu Thr Leu Leu Gly Leu Ser Ser Leu Val Gly Val Thr Trp Gly
      50                  55                  60                
 Leu Ala Ile Phe Thr Pro Leu Gly Leu Ser Thr Val Tyr Ile Phe Ala
  65                  70                  75                  80
 Leu Phe Asn Ser Leu Gln Gly Val Phe Ile Cys Cys Trp Phe Thr Ile
                  85                  90                  95    
 Leu Tyr Leu Pro Ser Gln Ser Thr Thr Val Ser Ser Ser Thr
             100                 105                 110



      <210> 2875
      <211> 248
      <212> PRT
      <213> Homo sapiens


      <400> 2875
 Met Val Leu Leu Glu Leu His Ile Ser Gln Thr Arg Thr His Ser Ser
   1               5                  10                  15    
 Pro Gly Trp His Ser Val Glu Thr Gly Ser Pro Met Met Lys Glu Glu
              20                  25                  30        
 Arg Lys Gly Gly Gly Glu Gly Glu Thr Leu Val Asp Arg Ala Asp Val
          35                  40                  45            
 Ile Trp Pro Lys Ile Ser Pro Lys Ala Cys Ile Pro His Ile His His
      50                  55                  60                
 Pro Ser Leu Leu Leu Gln Leu Asn Gln Ala Thr Arg Ser Phe Ala Asn
  65                  70                  75                  80
 Met Met Tyr Ile Pro Thr Leu Ser Pro Ser Asp His Thr Pro Lys Arg
                  85                  90                  95    
 Ala Pro Thr Ala Cys Leu Leu Ile Ile Lys Gln Val Met Lys Leu Leu
             100                 105                 110        
 Met Val Leu Ile Ile Trp Ala Val Asp Pro Gln Tyr Arg Leu Asn Ala
         115                 120                 125            
 Met Ile Ala Thr Thr Val Val Leu Leu Leu Leu Ala Leu Ile Gly Gly
     130                 135                 140                
 Ile Trp Thr Leu Arg Lys Ser Leu Lys Asn Thr Asp Glu Glu Glu Arg
 145                 150                 155                 160
 Tyr Phe Ile Ser Glu Lys Leu Ser Gln Asn Asp Gly Arg Gln Arg Val
                 165                 170                 175    
 Gly Phe Ala Ala Ala Thr Leu Ser His Arg Tyr Ile Ala Asp Arg Gln
             180                 185                 190        
 Leu Pro Asp Lys Ala Ile Asp Leu Ile Asp Glu Ala Ala Ser Ser Ile
         195                 200                 205            
 Arg Met Gln Ile Asp Ser Lys Pro Glu Glu Leu Asp Arg Leu Asp Arg
     210                 215                 220                
 Arg Ile Ile Gln Leu Lys Leu Glu Gln Gln Ala Leu Met Lys Glu Ser
 225                 230                 235                 240
 Asp Glu Ala Ser Glu Lys His Gly
                 245            



      <210> 2876
      <211> 1251
      <212> PRT
      <213> Homo sapiens


      <400> 2876
 Arg Leu Arg Leu Leu Leu Leu Glu Ser Val Ser Gly Leu Leu Gln Pro
   1               5                  10                  15    
 Arg Thr Gly Ser Ala Val Ala Pro Val His Pro Pro Asn Arg Ser Ala
              20                  25                  30        
 Pro His Leu Pro Gly Leu Met Cys Leu Leu Arg Leu His Gly Ser Val
          35                  40                  45            
 Gly Gly Ala Gln Asn Leu Ser Ala Leu Gly Ala Leu Val Ser Leu Ser
      50                  55                  60                
 Asn Ala Arg Leu Ser Ser Ile Lys Thr Arg Phe Glu Gly Leu Cys Leu
  65                  70                  75                  80
 Leu Ser Leu Leu Val Gly Glu Ser Pro Thr Glu Leu Phe Gln Gln His
                  85                  90                  95    
 Cys Val Ser Trp Leu Arg Ser Ile Gln Gln Val Leu Gln Thr Gln Asp
             100                 105                 110        
 Pro Pro Ala Thr Met Glu Leu Ala Val Ala Val Leu Arg Asp Leu Leu
         115                 120                 125            
 Arg Tyr Ala Ala Gln Leu Pro Ala Leu Phe Arg Asp Ile Ser Met Asn
     130                 135                 140                
 His Leu Pro Gly Leu Leu Thr Ser Leu Leu Gly Leu Arg Pro Glu Cys
 145                 150                 155                 160
 Glu Gln Ser Ala Leu Glu Gly Met Lys Ala Cys Met Thr Tyr Phe Pro
                 165                 170                 175    
 Arg Ala Cys Gly Ser Leu Lys Gly Lys Leu Ala Ser Phe Phe Leu Ser
             180                 185                 190        
 Arg Val Asp Ala Leu Ser Pro Gln Leu Gln Gln Leu Ala Cys Glu Cys
         195                 200                 205            
 Tyr Ser Arg Leu Pro Ser Leu Gly Ala Gly Phe Ser Gln Gly Leu Lys
     210                 215                 220                
 His Thr Glu Ser Trp Glu Gln Glu Leu His Ser Leu Leu Ala Ser Leu
 225                 230                 235                 240
 His Thr Leu Leu Gly Ala Leu Tyr Glu Gly Ala Glu Thr Ala Pro Val
                 245                 250                 255    
 Gln Asn Glu Gly Pro Gly Val Glu Met Leu Leu Ser Ser Glu Asp Gly
             260                 265                 270        
 Asp Ala His Val Leu Leu Gln Leu Arg Gln Arg Phe Ser Gly Leu Ala
         275                 280                 285            
 Arg Cys Leu Gly Leu Met Leu Ser Ser Glu Phe Gly Ala Pro Val Ser
     290                 295                 300                
 Val Pro Val Gln Glu Ile Leu Asp Phe Ile Cys Arg Thr Leu Ser Val
 305                 310                 315                 320
 Ser Ser Lys Asn Ile Val Ser Gly Ile Cys His Leu Phe Arg Ala Leu
                 325                 330                 335    
 Ala Gln Asp Thr Arg Gln Pro Gly Lys Tyr Trp Gly Pro Glu Ser Pro
             340                 345                 350        
 Gln Thr Val Ser Ser Trp Ser Pro Ser Gln Arg Ala Ser Thr Phe Val
         355                 360                 365            
 Gln Ile Thr Ser Leu Pro Met Cys Arg Asp Thr Gly Ala Gln Cys Gln
     370                 375                 380                
 Ser Val Ala Asn Ala Ser Leu Gly Glu Gly Glu Phe Gly Asp Ser Ala
 385                 390                 395                 400
 Glu Ser Leu Leu Arg Gly Pro Ala Ile Leu Leu Thr Phe His Pro Gly
                 405                 410                 415    
 Ser Ile Leu Glu Asp Arg Gly Leu Ile Leu Leu Gly Glu Met Arg Ser
             420                 425                 430        
 Gly Val Gly Phe Leu Thr Tyr Val Tyr Ile Cys Lys Trp Ser Phe Pro
         435                 440                 445            
 Val Ser Val Ser Leu Trp Leu Ser Leu Ser Ser Ser Thr Leu Tyr Leu
     450                 455                 460                
 Cys Pro Phe Phe Leu Gln Ser Leu His Gly Asp Gly Pro Cys Gly Cys
 465                 470                 475                 480
 Cys Cys Cys Pro Leu Ser Thr Leu Lys Ala Leu Asp Leu Leu Ser Ala
                 485                 490                 495    
 Leu Ile Leu Ala Cys Gly Ser Arg Leu Leu Arg Phe Gly Ile Leu Ile
             500                 505                 510        
 Gly Arg Leu Leu Pro Gln Val Leu Asn Ser Trp Ser Ile Gly Arg Asp
         515                 520                 525            
 Ser Leu Ser Pro Gly Gln Glu Arg Pro Tyr Ser Thr Val Arg Thr Lys
     530                 535                 540                
 Val Tyr Ala Ile Leu Glu Leu Trp Val Gln Val Cys Gly Ala Ser Ala
 545                 550                 555                 560
 Gly Met Leu Gln Gly Gly Ala Ser Gly Glu Ala Leu Leu Thr His Leu
                 565                 570                 575    
 Leu Ser Asp Ile Ser Pro Pro Ala Asp Ala Leu Lys Leu Arg Ser Pro
             580                 585                 590        
 Arg Gly Ser Pro Asp Gly Ser Leu Gln Thr Gly Lys Pro Ser Ala Pro
         595                 600                 605            
 Lys Lys Leu Lys Leu Asp Val Gly Glu Ala Met Ala Pro Pro Ser His
     610                 615                 620                
 Arg Lys Gly Asp Ser Asn Ala Asn Ser Asp Val Cys Ala Ala Ala Leu
 625                 630                 635                 640
 Arg Gly Leu Ser Arg Thr Ile Leu Met Cys Gly Pro Leu Ile Lys Glu
                 645                 650                 655    
 Glu Thr His Arg Arg Leu His Asp Leu Val Leu Pro Leu Val Met Gly
             660                 665                 670        
 Val Gln Gln Gly Glu Val Leu Gly Ser Ser Pro Tyr Thr Ser Ser Arg
         675                 680                 685            
 Cys Arg Arg Glu Leu Tyr Cys Leu Leu Leu Ala Leu Leu Leu Ala Pro
     690                 695                 700                
 Ser Pro Arg Cys Pro Leu Leu Leu Pro Val Pro Cys Lys Pro Ser Pro
 705                 710                 715                 720
 Ser Ala Ser Glu Lys Ile Ala Leu Arg Ser Pro Leu Ser Cys Ser Glu
                 725                 730                 735    
 Ala Leu Val Thr Cys Ala Ala Leu Thr His Pro Arg Val Pro Pro Leu
             740                 745                 750        
 Gln Pro Met Gly Pro Thr Cys Pro Thr Pro Ala Pro Val Pro Leu Leu
         755                 760                 765            
 Arg Pro His Arg Pro Ser Gly Pro His Arg Ser Ile Leu Arg Ala Pro
     770                 775                 780                
 Cys Pro Gln Trp Ala Pro Cys Pro Gln Gln Ala Pro Cys Pro Ser Ala
 785                 790                 795                 800
 Gly Pro Met Pro Ser Ala Gly Pro Val Pro Ser Glu Pro Trp Thr Ser
                 805                 810                 815    
 Thr Thr Ala Asn Leu Leu Gly Leu Leu Ser Arg Pro Ser Val Cys Pro
             820                 825                 830        
 Pro Arg Leu Leu Pro Gly Pro Glu Asn His Arg Ala Gly Ser Asn Glu
         835                 840                 845            
 Asp Pro Ile Leu Ala Pro Ser Gly Thr Pro Pro Pro Thr Ile Pro Pro
     850                 855                 860                
 Asp Glu Thr Phe Gly Gly Arg Val Pro Arg Pro Ala Phe Val His Tyr
 865                 870                 875                 880
 Asp Lys Glu Glu Ala Ser Asp Val Glu Ile Ser Leu Glu Ser Asp Ser
                 885                 890                 895    
 Asp Asp Ser Val Val Ile Val Pro Glu Gly Leu Pro Pro Leu Pro Pro
             900                 905                 910        
 Pro Pro Pro Ser Gly Ala Thr Pro Pro Pro Ile Ala Pro Thr Gly Pro
         915                 920                 925            
 Pro Thr Ala Ser Pro Pro Val Pro Ala Lys Glu Glu Pro Glu Glu Leu
     930                 935                 940                
 Pro Ala Ala Pro Gly Pro Leu Pro Pro Pro Pro Pro Pro Pro Pro Pro
 945                 950                 955                 960
 Val Pro Gly Pro Val Thr Leu Pro Pro Pro Gln Leu Val Pro Glu Gly
                 965                 970                 975    
 Thr Pro Gly Gly Gly Gly Pro Pro Ala Leu Glu Glu Asp Leu Thr Val
             980                 985                 990        
 Ile Asn Ile Asn Ser Ser Asp Glu Glu Glu Glu Glu Glu Glu Glu Glu
         995                1000                1005            
 Glu Glu Glu Glu Glu Glu Glu Glu Glu Glu Glu Glu Asp Phe Glu Glu
    1010                1015                1020                
 Glu Glu Glu Glu Glu Asp Phe Glu Glu Glu Glu Glu Asp Glu Glu Glu
1025                1030                1035                1040
 Tyr Phe Glu Glu Glu Glu Glu Glu Glu Glu Glu Phe Glu Glu Glu Phe
                1045                1050                1055    
 Glu Glu Glu Glu Gly Glu Leu Glu Glu Glu Glu Glu Glu Glu Asp Glu
            1060                1065                1070        
 Glu Glu Glu Glu Glu Leu Glu Glu Val Glu Asp Leu Glu Phe Gly Thr
        1075                1080                1085            
 Ala Gly Gly Glu Val Glu Glu Gly Ala Pro Pro Pro Ser Thr Leu Pro
    1090                1095                1100                
 Pro Ala Leu Pro Pro Pro Glu Ser Pro Pro Lys Val Gln Pro Glu Pro
1105                1110                1115                1120
 Glu Pro Glu Pro Gly Leu Leu Leu Glu Val Glu Glu Pro Gly Thr Glu
                1125                1130                1135    
 Glu Glu Arg Gly Ala Asp Thr Ala Pro Thr Leu Ala Pro Glu Ala Leu
            1140                1145                1150        
 Pro Ser Gln Gly Glu Val Glu Arg Glu Gly Glu Ser Pro Ala Ala Gly
        1155                1160                1165            
 Pro Pro Pro Gln Glu Leu Val Glu Glu Glu Pro Ser Ala Pro Pro Thr
    1170                1175                1180                
 Leu Leu Glu Glu Glu Thr Glu Asp Gly Ser Asp Lys Val Gln Pro Pro
1185                1190                1195                1200
 Pro Glu Thr Pro Ala Glu Glu Glu Met Glu Thr Glu Thr Glu Ala Glu
                1205                1210                1215    
 Ala Leu Gln Glu Lys Glu Gln Asp Asp Thr Ala Ala Met Leu Ala Asp
            1220                1225                1230        
 Phe Ile Asp Cys Pro Pro Asp Asp Glu Lys Pro Pro Pro Pro Ser Glu
        1235                1240                1245            
 Pro Asp Ser
    1250    



      <210> 2877
      <211> 85
      <212> PRT
      <213> Homo sapiens


      <400> 2877
 Met Gly Lys Gln Asp Ser Gln Arg Ala Val Arg His Gln Ala Ser His
   1               5                  10                  15    
 Cys Pro Tyr Leu Tyr Ser Gln Ala Ile Ile Arg Asn Asp Cys Arg Ser
              20                  25                  30        
 Asp Pro Thr Tyr Arg Pro Cys Cys Cys Glu Asp Glu Thr Arg Gly Ile
          35                  40                  45            
 Lys Lys Lys Leu Met Thr Asp Leu Leu Lys Glu Cys Met Gln Arg Ser
      50                  55                  60                
 Lys Asn Asn Lys Asp Cys Ala Lys Ile Gly Leu Met Cys Thr Val Lys
  65                  70                  75                  80
 Gln Gln Ala Thr Gly
                  85



      <210> 2878
      <211> 1113
      <212> PRT
      <213> Homo sapiens


      <400> 2878
 Asn Gln Glu Ser Leu Val Gln Cys Gln Gly Pro Ala Ile Ile Gly Ala
   1               5                  10                  15    
 Leu Leu Arg Lys Val Pro Ser Trp Ala Met Asp Met Asn Val Leu Met
              20                  25                  30        
 Ser Ala Gln Leu Leu Met Glu Gln Val Ala Ala Glu Gly Ser Gly Pro
          35                  40                  45            
 Leu Leu Tyr Leu Leu Tyr Gln His Leu Leu Phe Asn Phe His Leu Trp
      50                  55                  60                
 Thr Leu Ser Asp Phe Ala Val Arg Leu Gly His Ile Gln Tyr Met Ser
  65                  70                  75                  80
 Ser Ile Val Arg Glu His Arg Gln Lys Leu Arg Lys Lys Tyr Gly Val
                  85                  90                  95    
 Gln Phe Ile Leu Asp Ala Leu Arg Thr His Tyr Ser Pro Gln Arg Glu
             100                 105                 110        
 Arg Pro Leu Ala Ala Asp Asp Leu Arg Thr Val Gln Thr Ser Leu Leu
         115                 120                 125            
 Gly Leu Ala Arg Glu Phe Leu Val Arg Ser Leu Ser Ala Asp Asp Val
     130                 135                 140                
 Gln Val Thr Gln Thr Met Leu Ser Phe Leu Ala Ala Thr Gly Asp Asp
 145                 150                 155                 160
 Gly Gln Ala Val Gly Ala Leu Asp Leu Leu Leu Ala Leu Leu His Gly
                 165                 170                 175    
 Ser Leu Val Gln Glu Ser Leu Ala Val Phe Leu Leu Glu Pro Gly Asn
             180                 185                 190        
 Leu Glu Val Leu Leu Ala Leu Leu Val Arg Pro Gly Ser Leu Pro Leu
         195                 200                 205            
 Leu Pro Asp Arg Val Cys Lys Ile Leu Arg Arg Leu Gln Gln Asn Glu
     210                 215                 220                
 Arg Leu Pro Glu Arg Ser Arg Gln Arg Leu Arg Leu Arg Glu Cys Gly
 225                 230                 235                 240
 Leu Gln Gly Leu Val Ala Cys Leu Pro Glu Gly Thr Val Ser Pro Gln
                 245                 250                 255    
 Leu Cys Gln Gly Leu Tyr Lys Leu Phe Leu Gly Ala Asp Cys Leu Asn
             260                 265                 270        
 Leu Ser Asp Leu Leu Ala Val Val Gln Leu Ser Leu Gln Ala Asp Leu
         275                 280                 285            
 Ser Val Arg Leu Asp Ile Cys Arg Gln Leu Phe His Leu Ile Tyr Gly
     290                 295                 300                
 Gln Pro Asp Val Val Arg Leu Leu Ala Arg Gln Ala Gly Trp Gln Asp
 305                 310                 315                 320
 Val Leu Thr Arg Leu Tyr Val Leu Glu Ala Ala Thr Ala Gly Ser Pro
                 325                 330                 335    
 Pro Pro Ser Ser Pro Glu Ser Pro Thr Ser Pro Lys Pro Ala Pro Pro
             340                 345                 350        
 Lys Pro Pro Thr Glu Ser Pro Ala Glu Pro Ser Asp Val Phe Leu Pro
         355                 360                 365            
 Ser Glu Ala Pro Cys Pro Asp Pro Asp Gly Phe Tyr His Ala Leu Ser
     370                 375                 380                
 Pro Phe Cys Thr Pro Phe Asp Leu Gly Leu Glu Arg Ser Ser Val Gly
 385                 390                 395                 400
 Ser Gly Asn Thr Ala Gly Gly Gly Gly Ser Ser Gly Thr Leu Thr Pro
                 405                 410                 415    
 Ala Ser Gln Pro Gly Thr Pro Ser Pro Leu Asp Gly Pro Arg Pro Phe
             420                 425                 430        
 Pro Ala Ala Pro Gly Arg His Ser Ser Ser Leu Ser Asn Val Leu Glu
         435                 440                 445            
 Asp Gly Ser Leu Pro Glu Pro Thr Ile Ser Gly Asp Asp Thr Ser Asn
     450                 455                 460                
 Thr Ser Asn Pro Gln Gln Thr Ser Glu Glu Glu Leu Cys Asn Leu Leu
 465                 470                 475                 480
 Thr Asn Val Leu Phe Ser Val Thr Trp Arg Gly Val Glu Gly Ser Asp
                 485                 490                 495    
 Glu Ala Ala Trp Arg Glu Arg Gly Gln Val Phe Ser Val Leu Thr Gln
             500                 505                 510        
 Leu Gly Ala Ser Ala Thr Leu Val Arg Pro Pro Asp Cys Ile Lys Arg
         515                 520                 525            
 Ser Leu Leu Glu Met Met Leu Glu Ser Ala Leu Thr Asp Ile Lys Glu
     530                 535                 540                
 Ala Pro Val Gly Val Leu Ala Ser Leu Thr Gln Gln Ala Leu Trp Leu
 545                 550                 555                 560
 Leu Arg Leu Leu Gln Asp Phe Leu Cys Ala Glu Gly His Gly Asn Gln
                 565                 570                 575    
 Glu Leu Trp Ser Glu Lys Leu Phe Glu Gly Val Cys Ser Leu Leu Asp
             580                 585                 590        
 Arg Leu Gly Ala Trp Pro His Leu Ala Asn Gly Thr Ala Asp Leu Arg
         595                 600                 605            
 Glu Met Ala Gln Ile Gly Leu Arg Leu Val Leu Gly Tyr Ile Leu Leu
     610                 615                 620                
 Glu Asp Pro Gln Leu His Ala Gln Ala Tyr Val Arg Leu His Met Leu
 625                 630                 635                 640
 Leu Gln Thr Ala Val Pro Ala Arg Arg Glu Glu Ala Cys Tyr Val Leu
                 645                 650                 655    
 Ser Lys Leu Glu Ala Ala Leu Gly Arg Val Leu Asn Thr Ser Ser Leu
             660                 665                 670        
 Glu Ser Ala Thr Asp Glu Ala Gly Ser Pro Leu Ala Ala Ala Ala Ala
         675                 680                 685            
 Ala Ala Ala Ala Glu Arg Cys Ser Trp Leu Val Pro Leu Val Arg Thr
     690                 695                 700                
 Leu Leu Asp Arg Ala Tyr Glu Pro Leu Gly Leu Gln Trp Gly Leu Pro
 705                 710                 715                 720
 Ser Leu Pro Pro Thr Asn Gly Ser Pro Thr Phe Phe Glu Asp Phe Gln
                 725                 730                 735    
 Ala Phe Cys Ala Thr Pro Glu Trp Arg His Phe Ile Asp Lys Gln Val
             740                 745                 750        
 Gln Pro Thr Met Ser Gln Phe Glu Met Asp Thr Tyr Ala Lys Ser His
         755                 760                 765            
 Asp Leu Met Ser Gly Phe Trp Asn Ala Cys Tyr Asp Met Leu Met Ser
     770                 775                 780                
 Ser Gly Gln Arg Arg Gln Trp Glu Arg Ala Gln Ser Arg Arg Ala Phe
 785                 790                 795                 800
 Gln Glu Leu Val Leu Glu Pro Ala Gln Arg Arg Ala Arg Leu Glu Gly
                 805                 810                 815    
 Leu Arg Tyr Thr Ala Val Leu Lys Gln Gln Ala Thr Gln His Ser Met
             820                 825                 830        
 Ala Leu Leu His Trp Gly Ala Leu Trp Arg Gln Leu Ala Ser Pro Cys
         835                 840                 845            
 Gly Ala Trp Ala Leu Arg Asp Thr Pro Ile Pro Arg Trp Lys Leu Ser
     850                 855                 860                
 Ser Ala Glu Thr Tyr Ser Arg Met Arg Leu Lys Leu Val Pro Asn His
 865                 870                 875                 880
 His Phe Asp Pro His Leu Glu Ala Ser Ala Leu Arg Asp Asn Leu Gly
                 885                 890                 895    
 Glu Val Pro Leu Thr Pro Thr Glu Glu Ala Ser Leu Pro Leu Ala Val
             900                 905                 910        
 Thr Lys Glu Ala Lys Val Ser Thr Pro Pro Glu Leu Leu Gln Glu Asp
         915                 920                 925            
 Gln Leu Gly Glu Asp Glu Leu Ala Glu Leu Glu Thr Pro Met Glu Ala
     930                 935                 940                
 Ala Glu Leu Asp Glu Gln Arg Glu Lys Leu Val Leu Ser Ala Glu Cys
 945                 950                 955                 960
 Gln Leu Val Thr Val Val Ala Val Val Pro Gly Leu Leu Glu Val Thr
                 965                 970                 975    
 Thr Gln Asn Val Tyr Phe Tyr Asp Gly Ser Thr Glu Arg Val Glu Thr
             980                 985                 990        
 Glu Glu Gly Ile Gly Tyr Asp Phe Arg Arg Pro Leu Ala Gln Leu Arg
         995                1000                1005            
 Glu Val His Leu Arg Arg Phe Asn Leu Arg Arg Ser Ala Leu Glu Leu
    1010                1015                1020                
 Phe Phe Ile Asp Gln Ala Asn Tyr Phe Leu Asn Phe Pro Cys Lys Val
1025                1030                1035                1040
 Gly Thr Thr Pro Val Ser Ser Pro Ser Gln Thr Pro Arg Pro Gln Pro
                1045                1050                1055    
 Gly Pro Ile Pro Pro His Thr Gln Val Arg Asn Gln Val Tyr Ser Trp
            1060                1065                1070        
 Leu Leu Arg Leu Arg Pro Pro Ser Gln Gly Tyr Leu Ser Ser Arg Ser
        1075                1080                1085            
 Pro Gln Glu Met Leu Arg Ala Ser Gly Leu Thr Gln Val Arg Ala Leu
    1090                1095                1100                
 Gly Val Arg Asp Val Lys Ser Gly Pro
1105                1110            



      <210> 2879
      <211> 270
      <212> PRT
      <213> Homo sapiens

      <220>
      <221> misc_feature
      <222> (1)...(270)
      <223> Xaa = any amino acid or symbol as shown in the table 8 as set forth in Example 2


      <400> 2879
 Ala Asn Trp Thr Glu Pro Asp Asp Thr Lys Thr Met Trp Arg Leu Ser
   1               5                  10                  15    
 Val Pro Leu Asp Arg Ser Pro Gln Thr Gln Asn Cys Thr Gly Glu Pro
              20                  25                  30        
 Leu Met Pro Thr Gly Arg Gln Glu Leu Pro Gln Arg Gly Pro Glu Pro
          35                  40                  45            
 Met Glu Ala Pro Ala Pro Ala Arg Pro Gln Ser Arg Arg Val Pro Ala
      50                  55                  60                
 Ala Gly Pro Val Ala Arg Gln Pro His Met Arg Pro Pro His Ser Lys
  65                  70                  75                  80
 Gln Gly Glu Lys Gln Lys Met Pro Gly Ser Arg Trp Pro Gly Gln Arg
                  85                  90                  95    
 Gly Arg Gly Arg Trp Gly Ser Pro Leu Glu Ser Ala Xaa Xaa Thr Arg
             100                 105                 110        
 Lys Ile Phe Thr Gly Ile Pro Ile Leu Pro Leu Leu Pro Gly Thr Pro
         115                 120                 125            
 Gly Arg Pro Ala Pro Glu Glu Gly Met Gln Ser Ala Asp Lys Asn Arg
     130                 135                 140                
 Val Lys Arg Arg Gly Gly Thr Gln Arg Asn Ser Ala Leu Ala Leu Glu
 145                 150                 155                 160
 Phe Cys Glu Leu Leu Phe Val Ser Ser Lys Trp Phe Cys Ala Leu Pro
                 165                 170                 175    
 Ser Thr Leu Arg Leu Lys Ala Leu Ser Ala Ala Val Ala Leu Leu Ala
             180                 185                 190        
 Gly Asp Pro Glu Phe Gly Val Arg Asn Val Trp Val Trp Val Ala Gly
         195                 200                 205            
 Gly Val Arg Cys Lys Arg Val Ala His Arg Thr Thr Glu Ala Gly Ala
     210                 215                 220                
 Phe Phe Pro Asp Trp Phe Val Trp Val Phe Ala Ala Thr Lys Arg Gly
 225                 230                 235                 240
 Asp Gly Glu Thr Ser Gly Cys Glu His Ser Glu Pro Val Ser Gly Ser
                 245                 250                 255    
 Ser Gly Gly Ser Pro Pro Arg Gly Gln Tyr Leu Pro Gly Met
             260                 265                 270



      <210> 2880
      <211> 164
      <212> PRT
      <213> Homo sapiens

      <220>
      <221> misc_feature
      <222> (1)...(164)
      <223> Xaa = any amino acid or symbol as shown in the table 8 as set forth in Example 2


      <400> 2880
 Gln Leu Gly Ile Leu Arg Val Asn Leu Leu Gly Ile Asp Leu Arg Val
   1               5                  10                  15    
 Thr Gly His Gln Ala Ala Pro Pro Leu His Leu Leu Asp Leu Leu Gln
              20                  25                  30        
 Met His Ser Ser Pro Pro Cys Arg Pro Gln Xaa Ala Thr Ser Ser Pro
          35                  40                  45            
 Pro Pro Ser Leu Arg Cys Arg Ala Pro His Arg Xaa Ser Leu Ala Ala
      50                  55                  60                
 Pro Xaa Ala Pro Pro Pro Arg Pro Ser Leu Ser Ala Gly Ser Pro His
  65                  70                  75                  80
 Arg Lys Gly Pro Pro Gly Pro Ala Pro Thr Gly Ser Trp Ser Ser Gly
                  85                  90                  95    
 Asn Gln Ala Gly Leu Pro Cys Cys Leu Gly Trp Ala Ser Val Phe Leu
             100                 105                 110        
 Cys Pro Ser His Leu Pro Pro Pro His Leu Pro Gln Ser Ser Ala Ser
         115                 120                 125            
 Leu Ala Phe His Arg Val Lys His Leu Ile His Leu His Asn Ser Val
     130                 135                 140                
 Ile Asp Lys Met Lys Tyr Gln Leu Lys Phe Leu Cys Leu Leu Gly Glu
 145                 150                 155                 160
 Tyr Leu Ser Val
                



      <210> 2881
      <211> 534
      <212> PRT
      <213> Homo sapiens

      <220>
      <221> misc_feature
      <222> (1)...(534)
      <223> Xaa = any amino acid or symbol as shown in the table 8 as set forth in Example 2


      <400> 2881
 Pro Pro Gly Thr Gln Gly Ser Pro Gln Arg Thr Gly Asp His Gly Gly
   1               5                  10                  15    
 Lys Pro Pro Leu Pro Ala Glu Lys Pro Ala Pro Gly Pro Gly Leu Pro
              20                  25                  30        
 Ala Arg Ala Ser Arg Ala Glu Gly Arg Gly Ala Ser Gly Trp Lys Pro
          35                  40                  45            
 Gly Gly Gln Pro Ala Gly Gly Ser Trp Gln Gly Gly Asp Ala Gly Pro
      50                  55                  60                
 Arg Arg Pro Ala Ser Gly Asp Gln Arg Thr Ala Gly Ala Ala Lys Ala
  65                  70                  75                  80
 Leu Ala Gly Pro Ala Gly Glu Ala Ala Gly Gly Asp Arg Gly Ala Ala
                  85                  90                  95    
 Gln Gly Asp Pro Pro Ala Glu Ala Gly Gly Arg Gly Gly Xaa Thr Gln
             100                 105                 110        
 Ala Gly Gly Gly Ala Ser Arg Ala Arg Gly Ser Gly Ala Gln Arg Pro
         115                 120                 125            
 Gly Gly Pro Xaa Arg Gln Gly Gln Gly Asp Gly Gly Glu Ser Ala Ser
     130                 135                 140                
 Pro Ala Phe Gly Pro Cys Pro Gln Ser Ser Trp Gly Pro Pro Cys Ser
 145                 150                 155                 160
 Ile Pro Gly Pro Xaa Pro Ala Leu Pro Gly Ala Leu Xaa Gly Ala Val
                 165                 170                 175    
 Gly Arg Asp Pro Ala Gly Pro Pro Asp Gly Gly Pro Asp Thr Glu Pro
             180                 185                 190        
 Pro Gly Ser Pro Gly Gln Ala Glu Arg Trp Pro Glu Gly Cys Arg Pro
         195                 200                 205            
 Gln Gly Ser Trp His Cys Glu Gly Ala Pro Gln Gly Pro Gly Ala Gly
     210                 215                 220                
 Ala Arg Ala Arg Pro Arg Gln Gly Ser Arg Gly Pro Arg Gly Ala Pro
 225                 230                 235                 240
 Arg Arg Gly Ile Pro Trp Ala Lys Ser Gly Arg Thr Gly Gly Ser Gln
                 245                 250                 255    
 Asp Arg Lys Lys Pro Gly Lys Glu Val Ala Ala Thr Gly Thr Ser Ile
             260                 265                 270        
 Pro Glu Gly Ser Gln Leu Ala Arg Gly Arg Ala Arg Ser Arg Asp Gly
         275                 280                 285            
 Gly Pro Ser His Glu Ala Gln Ala Ser Glu Pro Arg Pro Gly Pro Cys
     290                 295                 300                
 Ser Gly Pro Ala Arg Trp Gly Gly Arg Ser Ser Cys Thr Ala Pro Gly
 305                 310                 315                 320
 Cys Val Thr Pro Ala Gly Thr Ala Gly His Leu Xaa Trp Arg Ala Gly
                 325                 330                 335    
 Trp Thr Ala Gly Pro Pro Ala Gly Pro Trp Arg Ser Pro Gly Asp Glu
             340                 345                 350        
 Lys Gly Pro Arg Gly Gly Pro Cys Ala Cys Val Pro Arg Ala Ala Glu
         355                 360                 365            
 Arg Arg Gly Gly Arg Cys Cys Pro Gly Ala Gln Ala Glu Ala Arg Ala
     370                 375                 380                
 Arg Ala Gly Ala Gln Thr Ser Cys Pro Gly Gly Pro Glu Ala Gly Gln
 385                 390                 395                 400
 Cys Gln Ala Gln Pro Gly Pro Glu Thr Ala Gly Trp Leu Arg Pro Pro
                 405                 410                 415    
 Glu Ala Thr Ala Gly Pro Trp Pro Ser Cys Arg Gly Ser Ala Gly Pro
             420                 425                 430        
 Glu Gly Trp Gly His His Trp Pro Xaa Pro Pro Ala Xaa Cys Pro Gly
         435                 440                 445            
 Glu Arg Pro Pro Trp Arg Pro Gly Cys Pro Ala Pro Pro Gly Cys Gly
     450                 455                 460                
 Gly Ser Ser Ala Gly Gly Pro Gln Pro Ala Ala Xaa Thr Gly Ala Trp
 465                 470                 475                 480
 Ala Ser Arg Gly Val Leu Ala Pro Ala Gly His Glu Gly His Ala Ser
                 485                 490                 495    
 His Cys Pro Pro Arg Pro Ala Ala Gly Leu Ser Gln Pro His Pro Ser
             500                 505                 510        
 Gln Thr Leu Glu Val Thr Leu Ala Ser Pro Gln Gly Phe Met Ser Glu
         515                 520                 525            
 Ala Leu Thr Lys Cys Glu
     530                



      <210> 2882
      <211> 293
      <212> PRT
      <213> Homo sapiens

      <220>
      <221> misc_feature
      <222> (1)...(293)
      <223> Xaa = any amino acid or symbol as shown in the table 8 as set forth in Example 2


      <400> 2882
 Cys Gln Pro Tyr Pro Arg Pro Arg Pro Arg Thr Gly Thr His Gly Ser
   1               5                  10                  15    
 Cys Gln Pro Pro Ser Gln Gly Ser Ala Glu Pro Xaa Gly Xaa Cys Leu
              20                  25                  30        
 Pro Thr Leu Leu Arg Met Ala Leu Lys Ala Gln Pro Thr Lys Val Asn
          35                  40                  45            
 Pro Arg Thr Leu Leu Asp Ser Asp Pro Asp Val Cys Ser Xaa Ala Ala
      50                  55                  60                
 His Ser Arg Val Leu Ile Thr Ser Pro Ser Arg Ala Pro Trp Arg Leu
  65                  70                  75                  80
 Pro Ser Pro Xaa Arg Arg Cys Pro Ala Gly Thr Cys Met Pro Ser Thr
                  85                  90                  95    
 Ala Thr Ser Ala Arg Xaa Cys Ser Gln Arg Pro Gly Ser Ser Trp Xaa
             100                 105                 110        
 Thr Xaa Thr Gly Ser Ser Leu Gly Ser Gln Ala Cys Gly Pro Ser Ser
         115                 120                 125            
 Ser Thr Ala Pro Pro Ser Ser Ser Trp Ser Ala Cys Thr Cys Gly Cys
     130                 135                 140                
 Ala Ala Ala Ala Arg Cys Ser Cys Ala Ala Ser Ser Thr Arg Ser Gly
 145                 150                 155                 160
 Pro Thr Cys Gly Ser Ser Pro Pro Ala Ser Ser Cys Ala Ser Ser Thr
                 165                 170                 175    
 Pro Ala Pro Gly Thr Thr Pro Ser Ser Thr Leu Thr Ser Trp Ala Ser
             180                 185                 190        
 Ser Pro Trp Ser Thr Pro Cys Pro Gly Ser Ala Gly Pro Ser Ser Trp
         195                 200                 205            
 Ser Ser Ser Ser Ser Ala Thr Pro Ser Ala Ser Ala Ser Thr Arg Thr
     210                 215                 220                
 Leu Ser Pro Gly Ser Pro Ala Ala Pro Xaa Pro Trp Pro Thr Ala Leu
 225                 230                 235                 240
 Ser Arg Leu Thr Glu Gln Glu Ala Val Trp Gly Ala Trp Gly Ile Ser
                 245                 250                 255    
 His Gly Asn Ser Trp Asp Lys Glu Thr Lys Leu Val Arg Leu Pro His
             260                 265                 270        
 Pro Cys Ser Lys Ser Pro Cys Phe Arg Pro Ser Leu Gln Pro Tyr Arg
         275                 280                 285            
 Ala His Arg Ala Pro
     290            



      <210> 2883
      <211> 105
      <212> PRT
      <213> Homo sapiens


      <400> 2883
 Gly Ile Pro Leu Ala Phe Leu Ser Glu Gly Gln Gly Ser Val Ala Ser
   1               5                  10                  15    
 Leu Ser Leu Thr Leu Leu Phe Leu Leu Val Gln Gly Gln Leu Phe Arg
              20                  25                  30        
 Gly Ser Ser Cys Phe Ser Ala Gly Cys His Gln Asp His Ala Leu Pro
          35                  40                  45            
 Trp Ser Asn Leu Asn His Leu Lys Asn Thr Val Ser Thr Trp Pro Pro
      50                  55                  60                
 Trp Val Arg Pro Asp His Leu Gly Thr Pro Ala Arg Arg Leu Gln Pro
  65                  70                  75                  80
 Asn Asn Asn Gln Met Cys Ser Ser Pro Ala Gly Leu Gln Phe His Ile
                  85                  90                  95    
 Cys His Val Ser Val Gln Met Trp Gly
             100                 105



      <210> 2884
      <211> 348
      <212> PRT
      <213> Homo sapiens


      <400> 2884
 Arg Tyr Arg Ala Ala Arg Asn Val Met Lys Asp Gln Arg Leu Val Phe
   1               5                  10                  15    
 His Ser Lys Val Arg Ser Ser Gly Tyr Ala Ser Ala Pro His Val Thr
              20                  25                  30        
 Met Phe Ser Pro Lys Thr Asn Ile Lys Ser Glu Gly Lys Gly Ser Ser
          35                  40                  45            
 Arg Ser Arg Ser Ser Cys Ala Arg Glu Ala Tyr Pro Val Glu Cys Ala
      50                  55                  60                
 Val Pro Thr Lys Pro Gly Pro Gln Val Ala Ala Ala Pro Thr Cys Thr
  65                  70                  75                  80
 Arg Val Cys Cys Ile Gln Tyr Ser Gly Asp Gly Gln Trp Leu Ala Cys
                  85                  90                  95    
 Gly Leu Ala Asn His Leu Leu Leu Val Phe Asp Ala Ser Leu Thr Gly
             100                 105                 110        
 Thr Pro Ala Val Phe Ser Gly His Asp Gly Ala Val Asn Ala Val Cys
         115                 120                 125            
 Trp Ser Gln Asp Arg Arg Trp Leu Leu Ser Ala Ala Arg Asp Gly Thr
     130                 135                 140                
 Leu Arg Met Trp Ser Ala Arg Gly Ala Glu Leu Ala Leu Leu Arg Tyr
 145                 150                 155                 160
 Lys Gln Lys Ser Lys Ser Lys Leu Ile Cys Arg Leu Ser Thr Thr Gly
                 165                 170                 175    
 Ala Val Asp Met Thr Ser Leu Ser Ala Val Asn Asp Phe Tyr Ser His
             180                 185                 190        
 Ile Val Leu Ala Ala Gly Arg Asn Arg Thr Val Glu Val Phe Asp Leu
         195                 200                 205            
 Asn Ala Gly Cys Ser Ala Ala Val Ile Val Glu Ala His Ser Arg Pro
     210                 215                 220                
 Val His Gln Ile Cys Gln Asn Lys Gly Ser Ser Phe Thr Thr Gln Gln
 225                 230                 235                 240
 Pro Gln Ala Tyr Asn Leu Phe Leu Thr Thr Ala Ile Gly Asp Gly Met
                 245                 250                 255    
 Arg Leu Trp Asp Leu Arg Thr Leu Arg Cys Glu Arg His Phe Glu Gly
             260                 265                 270        
 His Pro Thr Arg Gly Tyr Pro Cys Gly Ile Ala Phe Ser Pro Cys Gly
         275                 280                 285            
 Arg Phe Ala Ala Cys Gly Ala Glu Asp Arg His Ala Tyr Val Tyr Glu
     290                 295                 300                
 Met Gly Ser Ser Thr Phe Ser His Arg Leu Ala Gly His Thr Asp Thr
 305                 310                 315                 320
 Val Thr Gly Val Ala Phe Asn Pro Ser Ala Pro Gln Leu Ala Thr Ala
                 325                 330                 335    
 Thr Leu Asp Gly Lys Leu Gln Leu Phe Leu Ala Glu
             340                 345            



      <210> 2885
      <211> 1268
      <212> PRT
      <213> Homo sapiens


      <400> 2885
 Cys Pro Ser Leu Asp Ile Arg Ser Glu Val Ala Glu Leu Arg Gln Leu
   1               5                  10                  15    
 Glu Asn Cys Ser Val Val Glu Gly His Leu Gln Ile Leu Leu Met Phe
              20                  25                  30        
 Thr Ala Thr Gly Glu Asp Phe Arg Gly Leu Ser Phe Pro Arg Leu Thr
          35                  40                  45            
 Gln Val Thr Asp Tyr Leu Leu Leu Phe Arg Val Tyr Gly Leu Glu Ser
      50                  55                  60                
 Leu Arg Asp Leu Phe Pro Asn Leu Ala Val Ile Arg Gly Thr Arg Leu
  65                  70                  75                  80
 Phe Leu Gly Tyr Ala Leu Val Ile Phe Glu Met Pro His Leu Arg Asp
                  85                  90                  95    
 Val Ala Leu Pro Ala Leu Gly Ala Val Leu Arg Gly Ala Val Arg Val
             100                 105                 110        
 Glu Lys Asn Gln Glu Leu Cys His Leu Ser Thr Ile Asp Trp Gly Leu
         115                 120                 125            
 Leu Gln Pro Ala Pro Gly Ala Asn His Ile Val Gly Asn Lys Leu Gly
     130                 135                 140                
 Glu Glu Cys Ala Asp Val Cys Pro Gly Val Leu Gly Ala Ala Gly Glu
 145                 150                 155                 160
 Pro Cys Ala Lys Thr Thr Phe Ser Gly His Thr Asp Tyr Arg Cys Trp
                 165                 170                 175    
 Thr Ser Ser His Cys Gln Arg Val Cys Pro Cys Pro His Gly Met Ala
             180                 185                 190        
 Cys Thr Ala Arg Gly Glu Cys Cys His Thr Glu Cys Leu Gly Gly Cys
         195                 200                 205            
 Ser Gln Pro Glu Asp Pro Arg Ala Cys Val Ala Cys Arg His Leu Tyr
     210                 215                 220                
 Phe Gln Gly Ala Cys Leu Trp Ala Cys Pro Pro Gly Thr Tyr Gln Tyr
 225                 230                 235                 240
 Glu Ser Trp Arg Cys Val Thr Ala Glu Arg Cys Ala Ser Leu His Ser
                 245                 250                 255    
 Val Pro Gly Arg Ala Ser Thr Phe Gly Ile His Gln Gly Ser Cys Leu
             260                 265                 270        
 Ala Gln Cys Pro Ser Gly Phe Thr Arg Asn Ser Ser Ser Ile Phe Cys
         275                 280                 285            
 His Lys Cys Glu Gly Leu Cys Pro Lys Glu Cys Lys Val Gly Thr Lys
     290                 295                 300                
 Thr Ile Asp Ser Ile Gln Ala Ala Gln Asp Leu Val Gly Cys Thr His
 305                 310                 315                 320
 Val Glu Gly Ser Leu Ile Leu Asn Leu Arg Gln Gly Tyr Asn Leu Glu
                 325                 330                 335    
 Pro Gln Leu Gln His Ser Leu Gly Leu Val Glu Thr Ile Thr Gly Phe
             340                 345                 350        
 Leu Lys Ile Lys His Ser Phe Ala Leu Val Ser Leu Gly Phe Phe Lys
         355                 360                 365            
 Asn Leu Lys Leu Ile Arg Gly Asp Ala Met Val Asp Gly Asn Tyr Thr
     370                 375                 380                
 Leu Tyr Val Leu Asp Asn Gln Asn Leu Gln Gln Leu Gly Ser Trp Val
 385                 390                 395                 400
 Ala Ala Gly Leu Thr Ile Pro Val Gly Lys Ile Tyr Phe Ala Phe Asn
                 405                 410                 415    
 Pro Arg Leu Cys Leu Glu His Ile Tyr Arg Leu Glu Glu Val Thr Gly
             420                 425                 430        
 Thr Arg Gly Arg Gln Asn Lys Ala Glu Ile Asn Pro Arg Thr Asn Gly
         435                 440                 445            
 Asp Arg Ala Ala Cys Gln Thr Arg Thr Leu Arg Phe Val Ser Asn Val
     450                 455                 460                
 Thr Glu Ala Asp Arg Ile Leu Leu Arg Trp Glu Arg Tyr Glu Pro Leu
 465                 470                 475                 480
 Glu Ala Arg Asp Leu Leu Ser Phe Ile Val Tyr Tyr Lys Glu Ser Pro
                 485                 490                 495    
 Phe Gln Asn Ala Thr Glu His Val Gly Pro Asp Ala Cys Gly Thr Gln
             500                 505                 510        
 Ser Trp Asn Leu Leu Asp Val Glu Leu Pro Leu Ser Arg Thr Gln Glu
         515                 520                 525            
 Pro Gly Val Thr Leu Ala Ser Leu Lys Pro Trp Thr Gln Tyr Ala Val
     530                 535                 540                
 Phe Val Arg Ala Ile Thr Leu Thr Thr Glu Glu Asp Ser Pro His Gln
 545                 550                 555                 560
 Gly Ala Gln Ser Pro Ile Val Tyr Leu Arg Thr Leu Pro Ala Ala Pro
                 565                 570                 575    
 Thr Val Pro Gln Asp Val Ile Ser Thr Ser Asn Ser Ser Ser His Leu
             580                 585                 590        
 Leu Val Arg Trp Lys Pro Pro Thr Gln Arg Asn Gly Asn Leu Thr Tyr
         595                 600                 605            
 Tyr Leu Val Leu Trp Gln Arg Leu Ala Glu Asp Gly Asp Leu Tyr Leu
     610                 615                 620                
 Asn Asp Tyr Cys His Arg Gly Leu Arg Leu Pro Thr Ser Asn Asn Asp
 625                 630                 635                 640
 Pro Arg Phe Asp Gly Glu Asp Gly Asp Pro Glu Ala Glu Met Glu Ser
                 645                 650                 655    
 Asp Cys Cys Pro Cys Gln His Pro Pro Pro Gly Gln Val Leu Pro Pro
             660                 665                 670        
 Leu Glu Ala Gln Glu Ala Ser Phe Gln Lys Lys Phe Glu Asn Phe Leu
         675                 680                 685            
 His Asn Ala Ile Thr Ile Pro Ile Ser Pro Trp Lys Val Thr Ser Ile
     690                 695                 700                
 Asn Lys Ser Pro Gln Arg Asp Ser Gly Arg His Arg Arg Ala Ala Gly
 705                 710                 715                 720
 Pro Leu Arg Leu Gly Gly Asn Ser Ser Asp Phe Glu Ile Gln Glu Asp
                 725                 730                 735    
 Lys Val Pro Arg Glu Arg Ala Val Leu Ser Gly Leu Arg His Phe Thr
             740                 745                 750        
 Glu Tyr Arg Ile Asp Ile His Ala Cys Asn His Ala Ala His Thr Val
         755                 760                 765            
 Gly Cys Ser Ala Ala Thr Phe Val Phe Ala Arg Thr Met Pro His Arg
     770                 775                 780                
 Glu Ala Asp Gly Ile Pro Gly Lys Val Ala Trp Glu Ala Ser Ser Lys
 785                 790                 795                 800
 Asn Ser Val Leu Leu Arg Trp Leu Glu Pro Pro Asp Pro Asn Gly Leu
                 805                 810                 815    
 Ile Leu Lys Tyr Glu Ile Lys Tyr Arg Arg Leu Gly Glu Glu Ala Thr
             820                 825                 830        
 Val Leu Cys Val Ser Arg Leu Arg Tyr Ala Lys Phe Gly Gly Val His
         835                 840                 845            
 Leu Ala Leu Leu Pro Pro Gly Asn Tyr Ser Ala Arg Val Arg Ala Thr
     850                 855                 860                
 Ser Leu Ala Gly Asn Gly Ser Trp Thr Asp Ser Val Ala Phe Tyr Ile
 865                 870                 875                 880
 Leu Gly Pro Glu Glu Glu Asp Ala Gly Gly Leu His Val Leu Leu Thr
                 885                 890                 895    
 Ala Thr Pro Val Gly Leu Thr Leu Leu Ile Val Leu Ala Ala Leu Gly
             900                 905                 910        
 Phe Phe Tyr Gly Lys Lys Arg Asn Arg Thr Leu Tyr Ala Ser Val Asn
         915                 920                 925            
 Pro Glu Tyr Phe Ser Ala Ser Asp Met Tyr Val Pro Asp Glu Trp Glu
     930                 935                 940                
 Val Pro Arg Glu Gln Ile Ser Ile Ile Arg Glu Leu Gly Gln Gly Ser
 945                 950                 955                 960
 Phe Gly Met Val Tyr Glu Gly Leu Ala Arg Gly Leu Glu Ala Gly Glu
                 965                 970                 975    
 Glu Ser Thr Pro Val Ala Leu Lys Thr Val Asn Glu Leu Ala Ser Pro
             980                 985                 990        
 Arg Glu Cys Ile Glu Phe Leu Lys Glu Ala Ser Val Met Lys Ala Phe
         995                1000                1005            
 Lys Cys His His Val Val Arg Leu Leu Gly Val Val Ser Gln Gly Gln
    1010                1015                1020                
 Pro Thr Leu Val Ile Met Glu Leu Met Thr Arg Gly Asp Leu Lys Ser
1025                1030                1035                1040
 His Leu Arg Ser Leu Arg Pro Glu Ala Glu Asn Asn Pro Gly Leu Pro
                1045                1050                1055    
 Gln Pro Ala Leu Gly Glu Met Ile Gln Met Ala Gly Glu Ile Ala Asp
            1060                1065                1070        
 Gly Met Ala Tyr Leu Ala Ala Asn Lys Phe Val His Arg Asp Leu Ala
        1075                1080                1085            
 Ala Arg Asn Cys Met Val Ser Gln Asp Phe Thr Val Lys Ile Gly Asp
    1090                1095                1100                
 Phe Gly Met Thr Arg Asp Val Tyr Glu Thr Asp Tyr Tyr Arg Lys Gly
1105                1110                1115                1120
 Gly Lys Gly Leu Leu Pro Val Arg Trp Met Ala Pro Glu Ser Leu Lys
                1125                1130                1135    
 Asp Gly Ile Phe Thr Thr His Ser Asp Val Trp Ser Phe Gly Val Val
            1140                1145                1150        
 Leu Trp Glu Ile Val Thr Leu Ala Glu Gln Pro Tyr Gln Gly Leu Ser
        1155                1160                1165            
 Asn Glu Gln Val Leu Lys Phe Val Met Asp Gly Gly Val Leu Glu Glu
    1170                1175                1180                
 Leu Glu Gly Cys Pro Leu Gln Leu Gln Glu Leu Met Ser Arg Cys Trp
1185                1190                1195                1200
 Gln Pro Asn Pro Arg Leu Arg Pro Ser Phe Thr His Ile Leu Asp Ser
                1205                1210                1215    
 Ile Gln Glu Glu Leu Arg Pro Ser Phe Arg Leu Leu Ser Phe Tyr Tyr
            1220                1225                1230        
 Ser Pro Glu Cys Arg Gly Ala Arg Gly Ser Leu Pro Thr Thr Asp Ala
        1235                1240                1245            
 Glu Pro Asp Ser Ser Pro Thr Pro Arg Asp Cys Ser Pro Gln Asn Gly
    1250                1255                1260                
 Gly Pro Gly His
1265            



      <210> 2886
      <211> 1146
      <212> PRT
      <213> Homo sapiens


      <400> 2886
 Thr Ala Ser Gly Gln Gly Ser Val Lys Tyr Asp Ser Thr Asp Gln Gly
   1               5                  10                  15    
 Ser Pro Ala Ser Thr Pro Ser Thr Thr Arg Pro Leu Asn Ser Val Glu
              20                  25                  30        
 Pro Ala Thr Met Gln Pro Ile Pro Glu Ala His Ser Leu Tyr Val Thr
          35                  40                  45            
 Leu Ile Leu Ser Asp Ser Val Met Asn Ile Phe Lys Asp Arg Asn Phe
      50                  55                  60                
 Asp Ser Cys Cys Ile Cys Ala Cys Asn Met Asn Ile Lys Gly Ala Asp
  65                  70                  75                  80
 Val Gly Leu Tyr Ile Pro Asp Ser Ser Asn Glu Asp Gln Tyr Arg Cys
                  85                  90                  95    
 Thr Cys Gly Phe Ser Ala Ile Met Asn Arg Lys Leu Gly Tyr Asn Ser
             100                 105                 110        
 Gly Leu Phe Leu Glu Asp Glu Leu Asp Ile Phe Gly Lys Asn Ser Asp
         115                 120                 125            
 Ile Gly Gln Ala Ala Glu Arg Arg Leu Met Met Cys Gln Ser Thr Phe
     130                 135                 140                
 Leu Pro Gln Val Glu Gly Thr Lys Lys Pro Gln Glu Pro Pro Ile Ser
 145                 150                 155                 160
 Leu Leu Leu Leu Leu Gln Asn Gln His Thr Gln Pro Phe Ala Ser Leu
                 165                 170                 175    
 Asn Phe Leu Asp Tyr Ile Ser Ser Asn Asn Arg Gln Thr Leu Pro Cys
             180                 185                 190        
 Val Ser Trp Ser Tyr Asp Arg Val Gln Ala Asp Asn Asn Asp Tyr Trp
         195                 200                 205            
 Thr Glu Cys Phe Asn Ala Leu Glu Gln Gly Arg Gln Tyr Val Asp Asn
     210                 215                 220                
 Pro Thr Gly Gly Lys Val Asp Glu Ala Leu Val Arg Ser Ala Thr Val
 225                 230                 235                 240
 His Ser Trp Pro His Ser Asn Val Leu Asp Ile Ser Met Leu Ser Ser
                 245                 250                 255    
 Gln Asp Val Val Arg Met Leu Leu Ser Leu Gln Pro Phe Leu Gln Asp
             260                 265                 270        
 Ala Ile Gln Lys Lys Arg Thr Gly Arg Thr Trp Glu Asn Ile Gln His
         275                 280                 285            
 Val Gln Gly Pro Leu Thr Trp Gln Gln Phe His Lys Met Ala Gly Arg
     290                 295                 300                
 Gly Thr Tyr Gly Ser Glu Glu Ser Pro Glu Pro Leu Pro Ile Pro Thr
 305                 310                 315                 320
 Leu Leu Val Gly Tyr Asp Lys Asp Phe Leu Thr Ile Ser Pro Phe Ser
                 325                 330                 335    
 Leu Pro Phe Trp Glu Arg Leu Leu Leu Asp Pro Tyr Gly Gly His Arg
             340                 345                 350        
 Asp Val Ala Tyr Ile Val Val Cys Pro Glu Asn Glu Ala Leu Leu Glu
         355                 360                 365            
 Gly Ala Lys Thr Phe Phe Arg Asp Leu Ser Ala Val Tyr Glu Met Cys
     370                 375                 380                
 Arg Leu Gly Gln His Lys Pro Ile Cys Lys Val Leu Arg Asp Gly Ile
 385                 390                 395                 400
 Met Arg Val Gly Lys Thr Val Ala Gln Lys Leu Thr Asp Glu Leu Val
                 405                 410                 415    
 Ser Glu Trp Phe Asn Gln Pro Trp Ser Gly Glu Glu Asn Asp Asn His
             420                 425                 430        
 Ser Arg Leu Lys Leu Tyr Ala Gln Val Cys Arg His His Leu Ala Pro
         435                 440                 445            
 Tyr Leu Ala Thr Leu Gln Leu Asp Ser Ser Leu Leu Ile Pro Pro Lys
     450                 455                 460                
 Tyr Gln Thr Pro Pro Ala Ala Ala Gln Gly Gln Ala Thr Pro Gly Asn
 465                 470                 475                 480
 Ala Gly Pro Leu Ala Pro Asn Gly Ser Ala Ala Pro Pro Ala Gly Ser
                 485                 490                 495    
 Ala Phe Asn Pro Thr Ser Asn Ser Ser Ser Thr Asn Pro Ala Ala Ser
             500                 505                 510        
 Ser Ser Ala Ser Gly Ser Ser Val Pro Pro Val Ser Ser Ser Ala Ser
         515                 520                 525            
 Ala Pro Gly Ile Ser Gln Ile Ser Thr Thr Ser Ser Ser Gly Phe Ser
     530                 535                 540                
 Gly Ser Val Gly Gly Gln Asn Pro Ser Thr Gly Gly Ile Ser Ala Asp
 545                 550                 555                 560
 Arg Thr Gln Gly Asn Ile Gly Cys Gly Gly Asp Thr Asp Pro Gly Gln
                 565                 570                 575    
 Ser Ser Ser Gln Pro Ser Gln Asp Gly Gln Glu Ser Val Thr Glu Arg
             580                 585                 590        
 Glu Arg Ile Gly Ile Pro Thr Glu Pro Asp Ser Ala Asp Ser His Ala
         595                 600                 605            
 His Pro Pro Ala Val Val Ile Tyr Met Val Asp Pro Phe Thr Tyr Ala
     610                 615                 620                
 Ala Glu Glu Asp Ser Thr Ser Gly Asn Phe Trp Leu Leu Ser Leu Met
 625                 630                 635                 640
 Arg Cys Tyr Thr Glu Met Leu Asp Asn Leu Pro Glu His Met Arg Asn
                 645                 650                 655    
 Ser Phe Ile Leu Gln Ile Val Pro Cys Gln Tyr Met Leu Gln Thr Met
             660                 665                 670        
 Lys Asp Glu Gln Val Phe Tyr Ile Gln Tyr Leu Lys Ser Met Ala Phe
         675                 680                 685            
 Ser Val Tyr Cys Gln Cys Arg Arg Pro Leu Pro Thr Gln Ile His Ile
     690                 695                 700                
 Lys Ser Leu Thr Gly Phe Gly Pro Ala Ala Ser Ile Glu Met Thr Leu
 705                 710                 715                 720
 Lys Asn Pro Glu Arg Pro Ser Pro Ile Gln Leu Tyr Ser Pro Pro Phe
                 725                 730                 735    
 Ile Leu Ala Pro Ile Lys Asp Lys Gln Thr Glu Leu Gly Glu Thr Phe
             740                 745                 750        
 Gly Glu Ala Ser Gln Lys Tyr Asn Val Leu Phe Val Gly Tyr Cys Leu
         755                 760                 765            
 Ser His Asp Gln Arg Trp Leu Leu Ala Ser Cys Thr Asp Leu His Gly
     770                 775                 780                
 Glu Leu Leu Glu Thr Cys Val Val Asn Ile Ala Leu Pro Asn Arg Ser
 785                 790                 795                 800
 Arg Arg Ser Lys Val Ser Ala Arg Lys Ile Gly Leu Gln Lys Leu Trp
                 805                 810                 815    
 Glu Trp Cys Ile Gly Ile Val Gln Met Thr Ser Leu Pro Trp Arg Val
             820                 825                 830        
 Val Ile Gly Arg Leu Gly Arg Leu Gly His Gly Glu Leu Lys Asp Trp
         835                 840                 845            
 Ser Ile Leu Leu Gly Glu Cys Ser Leu Gln Thr Ile Ser Lys Lys Leu
     850                 855                 860                
 Lys Asp Val Cys Arg Met Cys Gly Ile Ser Ala Ala Asp Ser Pro Ser
 865                 870                 875                 880
 Ile Leu Ser Ala Cys Leu Val Ala Met Glu Pro Gln Gly Ser Phe Val
                 885                 890                 895    
 Val Met Pro Asp Ala Val Thr Met Gly Ser Val Phe Gly Arg Ser Thr
             900                 905                 910        
 Ala Leu Asn Met Gln Ser Ser Gln Leu Asn Thr Pro Gln Asp Ala Ser
         915                 920                 925            
 Cys Thr His Ile Leu Val Phe Pro Thr Ser Ser Thr Ile Gln Val Ala
     930                 935                 940                
 Pro Ala Asn Tyr Pro Asn Glu Asp Gly Phe Ser Pro Asn Asn Asp Asp
 945                 950                 955                 960
 Met Phe Val Asp Leu Pro Phe Pro Asp Asp Met Asp Asn Asp Ile Gly
                 965                 970                 975    
 Ile Leu Met Thr Gly Asn Leu His Ser Ser Pro Asn Ser Ser Pro Val
             980                 985                 990        
 Pro Ser Pro Gly Ser Pro Ser Gly Ile Gly Val Gly Ser His Phe Gln
         995                1000                1005            
 His Ser Arg Ser Gln Gly Glu Arg Leu Leu Ser Arg Glu Ala Pro Glu
    1010                1015                1020                
 Glu Leu Lys Gln Gln Pro Leu Ala Leu Gly Tyr Phe Val Ser Thr Ala
1025                1030                1035                1040
 Lys Ala Glu Asn Leu Pro Gln Trp Phe Trp Ser Ser Cys Pro Gln Ala
                1045                1050                1055    
 Gln Asn Gln Cys Pro Leu Phe Leu Lys Ala Ser Leu His His His Ile
            1060                1065                1070        
 Ser Val Ala Gln Thr Asp Glu Leu Leu Pro Ala Arg Asn Ser Gln Arg
        1075                1080                1085            
 Val Pro His Pro Leu Asp Ser Lys Thr Thr Ser Asp Val Leu Arg Phe
    1090                1095                1100                
 Val Leu Glu Gln Tyr Asn Ala Leu Ser Trp Leu Thr Cys Asn Pro Ala
1105                1110                1115                1120
 Thr Gln Asp Arg Thr Ser Cys Leu Pro Val His Phe Val Val Leu Thr
                1125                1130                1135    
 Gln Leu Tyr Asn Ala Ile Met Asn Ile Leu
            1140                1145    



      <210> 2887
      <211> 597
      <212> PRT
      <213> Homo sapiens


      <400> 2887
 Leu Gly Leu Gly Ser Gly Thr Leu Leu Ser Val Ser Glu Tyr Lys Lys
   1               5                  10                  15    
 Lys Tyr Arg Glu His Val Leu Gln Leu His Ala Arg Val Lys Glu Arg
              20                  25                  30        
 Asn Ala Arg Ser Val Lys Ile Thr Lys Arg Phe Thr Lys Leu Leu Ile
          35                  40                  45            
 Ala Pro Glu Ser Ala Ala Pro Glu Glu Ala Leu Gly Pro Ala Glu Glu
      50                  55                  60                
 Pro Glu Pro Gly Arg Ala Arg Arg Ser Asp Thr His Thr Phe Asn Arg
  65                  70                  75                  80
 Leu Phe Arg Arg Asp Glu Glu Gly Arg Arg Pro Leu Thr Val Val Leu
                  85                  90                  95    
 Gln Gly Pro Ala Gly Ile Gly Lys Thr Met Ala Ala Lys Lys Ile Leu
             100                 105                 110        
 Tyr Asp Trp Ala Ala Gly Lys Leu Tyr Gln Gly Gln Val Asp Phe Ala
         115                 120                 125            
 Phe Phe Met Pro Cys Gly Glu Leu Leu Glu Arg Pro Gly Thr Arg Ser
     130                 135                 140                
 Leu Ala Asp Leu Ile Leu Asp Gln Cys Pro Asp Arg Gly Ala Pro Val
 145                 150                 155                 160
 Pro Gln Met Leu Ala Gln Pro Gln Arg Leu Leu Phe Ile Leu Asp Gly
                 165                 170                 175    
 Ala Asp Glu Leu Pro Ala Leu Gly Gly Pro Glu Ala Ala Pro Cys Thr
             180                 185                 190        
 Asp Pro Phe Glu Ala Ala Ser Gly Ala Arg Val Leu Gly Gly Leu Leu
         195                 200                 205            
 Ser Lys Ala Leu Leu Pro Thr Ala Leu Leu Leu Val Thr Thr Arg Ala
     210                 215                 220                
 Ala Ala Pro Gly Arg Leu Gln Gly Arg Leu Cys Ser Pro Gln Cys Ala
 225                 230                 235                 240
 Glu Val Arg Gly Phe Ser Asp Lys Asp Lys Lys Lys Tyr Phe Tyr Lys
                 245                 250                 255    
 Phe Phe Arg Asp Glu Arg Arg Ala Glu Arg Ala Tyr Arg Phe Val Lys
             260                 265                 270        
 Glu Asn Glu Thr Leu Phe Ala Leu Cys Phe Val Pro Phe Val Cys Trp
         275                 280                 285            
 Ile Val Cys Thr Val Leu Arg Gln Gln Leu Glu Leu Gly Arg Asp Leu
     290                 295                 300                
 Ser Arg Thr Ser Lys Thr Thr Thr Ser Val Tyr Leu Leu Phe Ile Thr
 305                 310                 315                 320
 Ser Val Leu Ser Ser Ala Pro Val Ala Asp Gly Pro Arg Leu Gln Gly
                 325                 330                 335    
 Asp Leu Arg Asn Leu Cys Arg Leu Ala Arg Glu Gly Val Leu Gly Arg
             340                 345                 350        
 Arg Ala Gln Phe Ala Glu Lys Glu Leu Glu Gln Leu Glu Leu Arg Gly
         355                 360                 365            
 Ser Lys Val Gln Thr Leu Phe Leu Ser Lys Lys Glu Leu Pro Gly Val
     370                 375                 380                
 Leu Glu Thr Glu Val Thr Tyr Gln Phe Ile Asp Gln Ser Phe Gln Glu
 385                 390                 395                 400
 Phe Leu Ala Ala Leu Ser Tyr Leu Leu Glu Asp Gly Gly Val Pro Arg
                 405                 410                 415    
 Thr Ala Ala Gly Gly Val Gly Thr Leu Leu Arg Gly Asp Ala Gln Pro
             420                 425                 430        
 His Ser His Leu Val Leu Thr Thr Arg Phe Leu Phe Gly Leu Leu Ser
         435                 440                 445            
 Ala Glu Arg Met Arg Asp Ile Glu Arg His Phe Gly Cys Met Val Ser
     450                 455                 460                
 Glu Arg Val Lys Gln Glu Ala Leu Arg Trp Val Gln Gly Gln Gly Gln
 465                 470                 475                 480
 Gly Cys Pro Gly Val Ala Pro Glu Val Thr Glu Gly Ala Lys Gly Leu
                 485                 490                 495    
 Glu Asp Thr Glu Glu Pro Glu Glu Glu Glu Glu Gly Glu Glu Pro Asn
             500                 505                 510        
 Tyr Pro Leu Glu Leu Leu Tyr Cys Leu Tyr Glu Thr Gln Glu Asp Ala
         515                 520                 525            
 Phe Val Arg Gln Ala Leu Cys Arg Phe Pro Glu Leu Ala Leu Gln Arg
     530                 535                 540                
 Val Arg Phe Cys Arg Met Asp Val Ala Val Leu Ser Tyr Cys Val Arg
 545                 550                 555                 560
 Cys Cys Pro Ala Gly Gln Ala Leu Arg Leu Ile Ser Cys Arg Leu Val
                 565                 570                 575    
 Ala Ala Gln Glu Lys Lys Lys Lys Ser Leu Gly Lys Arg Leu Gln Ala
             580                 585                 590        
 Ser Leu Gly Gly Gly
         595        



      <210> 2888
      <211> 168
      <212> PRT
      <213> Homo sapiens


      <400> 2888
 Asn Thr Gly Ala Leu Val Ala Cys His Val Ser Val Met Glu Tyr Val
   1               5                  10                  15    
 Thr Ala Val Val Cys Leu Gly Phe Pro Leu Leu Thr Val Asp Gly Pro
              20                  25                  30        
 Arg Gly Asp Val Asp Asp Pro Leu Leu Asp Met Lys Thr Pro Val Leu
          35                  40                  45            
 Phe Val Ile Gly Gln Asn Ser Leu Gln Cys His Pro Glu Ala Met Glu
      50                  55                  60                
 Asp Phe Arg Glu Lys Ile Arg Ala Glu Asn Ser Leu Val Val Val Gly
  65                  70                  75                  80
 Gly Ala Asp Asp Asn Leu Ser Gln Pro Ser Pro Phe Ser Gly Leu Gln
                  85                  90                  95    
 Gln His Cys Thr Gln Cys Leu Ala His Thr Ala Glu Pro Pro Gly Gly
             100                 105                 110        
 His Ile Ser Trp Gln Leu Pro Pro Arg Leu Glu Gly Pro His His His
         115                 120                 125            
 Tyr Ser Asp Thr Ser Trp Pro Ala Glu Gln Asp His Tyr Thr Glu Pro
     130                 135                 140                
 Tyr Gly Leu Arg Ser Ser Pro Ile Arg Gly Val Leu Phe Pro Gly Ala
 145                 150                 155                 160
 Ala Leu Gln Leu Thr Glu Ala Gly
                 165            



      <210> 2889
      <211> 145
      <212> PRT
      <213> Homo sapiens


      <400> 2889
 Trp Lys Met Lys Lys Met Cys Asn Trp Leu Arg Ile Ile Asn Tyr Thr
   1               5                  10                  15    
 Pro Asp Met Ala Arg Ala Ala Val Asp Glu Ala Ile Gln Glu Gly Leu
              20                  25                  30        
 Glu Val Trp Ser Lys Val Thr Pro Leu Lys Phe Thr Lys Ile Ser Lys
          35                  40                  45            
 Gly Ile Ala Asp Ile Met Ile Ala Phe Arg Thr Arg Val His Gly Arg
      50                  55                  60                
 Cys Pro Arg Tyr Phe Asp Gly Pro Leu Gly Val Leu Gly His Ala Phe
  65                  70                  75                  80
 Pro Pro Gly Pro Gly Leu Gly Gly Asp Thr His Phe Asp Glu Asp Glu
                  85                  90                  95    
 Asn Trp Thr Lys Asp Gly Ala Asp Leu His Asp Asn Ser Pro Phe Tyr
             100                 105                 110        
 Gly His Asp Gly Cys Leu Ala His Ala Phe Pro Pro Gly Pro Gly Ile
         115                 120                 125            
 Gly Gly Asp Val His Phe Asp Asn Asp Glu Thr Arg Thr Lys Asp Phe
     130                 135                 140                
 Arg
 145



      <210> 2890
      <211> 83
      <212> PRT
      <213> Homo sapiens

      <220>
      <221> misc_feature
      <222> (1)...(83)
      <223> Xaa = any amino acid or symbol as shown in the table 8 as set forth in Example 2


      <400> 2890
 Asp Gly Arg Gln Leu Arg Arg Gly Ser Leu Gly Gly Ala Leu Thr Gly
   1               5                  10                  15    
 Arg Tyr Leu Leu Pro Asn Pro Val Ala Gly Gln Ala Trp Pro Ala Ser
              20                  25                  30        
 Ala Glu Thr Ser Asn Leu Val Gly Met Arg Ser Gln Ala Leu Gly Gln
          35                  40                  45            
 Ser Ala Pro Ser Leu Thr Ala Ser Leu Pro Cys Val Ser Lys Cys Trp
      50                  55                  60                
 Glu Asn Ile Pro Pro Trp Met Asn Trp Pro Pro His Xaa Ile Lys His
  65                  70                  75                  80
 Ile Gln Ser
            



      <210> 2891
      <211> 656
      <212> PRT
      <213> Homo sapiens


      <400> 2891
 Gly Asp Ala Gly Leu Gly Ser Gly Val Arg Ser Gly Arg Arg Arg Arg
   1               5                  10                  15    
 Cys Leu Gly Gly Ser Ser Ala Ser Ser Gly Asn Gln Pro Pro Gln Glu
              20                  25                  30        
 Leu Gly Leu Gly Glu Leu Leu Glu Glu Phe Ser Arg Thr Gln Tyr Arg
          35                  40                  45            
 Ala Lys Asp Gly Ser Gly Thr Gly Gly Ser Lys Val Glu Arg Ile Glu
      50                  55                  60                
 Lys Arg Cys Leu Glu Leu Phe Gly Arg Tyr Tyr Cys Phe Ser Val Ile
  65                  70                  75                  80
 Pro Asn Thr Asn Gly Asp Ile Cys Gly His Tyr Pro Arg His Ile Val
                  85                  90                  95    
 Phe Leu Glu Tyr Glu Ser Ser Glu Lys Glu Lys Asp Thr Phe Glu Ser
             100                 105                 110        
 Thr Val Gln Val Ser Lys Leu Gln Asp Leu Ile His Arg Ser Lys Met
         115                 120                 125            
 Ala Arg Cys Arg Gly Arg Phe Val Cys Pro Val Ile Leu Phe Lys Gly
     130                 135                 140                
 Lys His Ile Cys Arg Ser Ala Thr Leu Ala Gly Trp Gly Glu Leu Tyr
 145                 150                 155                 160
 Gly Arg Ser Gly Tyr Asn Tyr Phe Phe Ser Gly Gly Ala Asp Asp Ala
                 165                 170                 175    
 Trp Ala Asp Val Glu Asp Val Thr Glu Glu Asp Cys Ala Leu Arg Ser
             180                 185                 190        
 Gly Asp Thr His Leu Phe Asp Lys Val Arg Gly Tyr Asp Ile Lys Leu
         195                 200                 205            
 Leu Arg Tyr Leu Ser Val Lys Tyr Ile Cys Asp Leu Met Val Glu Asn
     210                 215                 220                
 Lys Lys Val Lys Phe Gly Met Asn Val Thr Ser Ser Glu Lys Val Asp
 225                 230                 235                 240
 Lys Ala Gln Arg Tyr Ala Asp Phe Thr Leu Leu Ser Ile Pro Tyr Pro
                 245                 250                 255    
 Gly Cys Glu Phe Phe Lys Glu Tyr Lys Asp Arg Asp Tyr Met Ala Glu
             260                 265                 270        
 Gly Leu Ile Phe Asn Trp Lys Gln Asp Tyr Val Asp Ala Pro Leu Ser
         275                 280                 285            
 Ile Pro Asp Phe Leu Thr His Ser Leu Asn Ile Asp Trp Ser Gln Tyr
     290                 295                 300                
 Gln Cys Trp Asp Leu Val Gln Gln Thr Gln Asn Tyr Leu Lys Leu Leu
 305                 310                 315                 320
 Leu Ser Leu Val Asn Ser Asp Asp Asp Ser Gly Leu Leu Val His Cys
                 325                 330                 335    
 Ile Ser Gly Trp Asp Arg Thr Pro Leu Phe Ile Ser Leu Leu Arg Leu
             340                 345                 350        
 Ser Leu Trp Ala Asp Gly Leu Ile His Thr Ser Leu Lys Pro Thr Glu
         355                 360                 365            
 Ile Leu Tyr Leu Thr Val Ala Tyr Asp Trp Phe Leu Phe Gly His Met
     370                 375                 380                
 Leu Val Asp Arg Leu Ser Lys Gly Glu Glu Ile Phe Phe Phe Cys Phe
 385                 390                 395                 400
 Asn Phe Leu Lys His Ile Thr Ser Glu Glu Phe Ser Ala Leu Lys Thr
                 405                 410                 415    
 Gln Arg Arg Lys Ser Leu Pro Ala Arg Asp Gly Gly Phe Thr Leu Glu
             420                 425                 430        
 Asp Ile Cys Met Leu Arg Arg Lys Asp Arg Gly Ser Thr Thr Ser Leu
         435                 440                 445            
 Gly Ser Asp Phe Ser Leu Val Met Glu Ser Ser Pro Gly Ala Thr Gly
     450                 455                 460                
 Ser Phe Thr Tyr Glu Ala Val Glu Leu Val Pro Ala Gly Ala Pro Thr
 465                 470                 475                 480
 Gln Ala Ala Trp Arg Lys Ser His Ser Ser Ser Pro Gln Ser Val Pro
                 485                 490                 495    
 Gly Thr Gly His Asn Pro Gln Arg Thr Ala Cys Leu Pro Ser Arg Gly
             500                 505                 510        
 Trp Arg Ile Ala Arg Ser Ser Ser Ser Ser Ser Ser Asn His Ser Asp
         515                 520                 525            
 Asn Phe Phe Arg Met Gly Ser Ser Pro Leu Glu Val Pro Lys Pro Arg
     530                 535                 540                
 Ser Val Asp His Pro Leu Pro Gly Ser Ser Leu Ser Thr Asp Tyr Gly
 545                 550                 555                 560
 Ser Trp Gln Met Val Thr Gly Cys Gly Ser Ile Gln Glu Arg Ala Val
                 565                 570                 575    
 Leu His Thr Asp Ser Ser Leu Pro Phe Ser Phe Pro Asp Glu Leu Pro
             580                 585                 590        
 Asn Ser Cys Leu Leu Ala Ala Leu Ser Asp Arg Glu Thr Arg Leu Gln
         595                 600                 605            
 Glu Val Arg Ser Ala Phe Leu Ala Ala Tyr Ser Ser Thr Val Gly Leu
     610                 615                 620                
 Arg Ala Val Ala Pro Ser Pro Ser Gly Ala Ile Gly Gly Leu Leu Glu
 625                 630                 635                 640
 Gln Phe Ala Arg Gly Val Gly Leu Arg Ser Ile Ser Ser Asn Ala Leu
                 645                 650                 655    



      <210> 2892
      <211> 489
      <212> PRT
      <213> Homo sapiens


      <400> 2892
 Pro Arg Gly Cys Trp Ser Ser Cys Leu Asp Ala Met Phe Arg Leu Asn
   1               5                  10                  15    
 Ser Leu Ser Ala Leu Ala Glu Leu Ala Val Gly Ser Arg Trp Tyr His
              20                  25                  30        
 Gly Gly Ser Gln Pro Ile Gln Ile Arg Arg Arg Leu Met Met Val Ala
          35                  40                  45            
 Phe Leu Gly Ala Ser Ala Val Thr Ala Ser Thr Gly Leu Leu Trp Lys
      50                  55                  60                
 Arg Ala His Ala Glu Ser Pro Pro Cys Val Asp Asn Leu Lys Ser Asp
  65                  70                  75                  80
 Ile Gly Asp Lys Gly Lys Asn Lys Asp Glu Gly Asp Val Cys Asn His
                  85                  90                  95    
 Glu Lys Lys Thr Ala Asp Leu Ala Pro His Pro Glu Glu Lys Lys Lys
             100                 105                 110        
 Lys Arg Ser Gly Phe Arg Asp Arg Lys Val Met Glu Tyr Glu Asn Arg
         115                 120                 125            
 Ile Arg Ala Tyr Ser Thr Pro Asp Lys Ile Phe Arg Tyr Phe Ala Thr
     130                 135                 140                
 Leu Lys Val Ile Ser Glu Pro Gly Glu Ala Glu Val Phe Met Thr Pro
 145                 150                 155                 160
 Glu Asp Phe Val Arg Ser Ile Thr Pro Asn Glu Lys Gln Pro Glu His
                 165                 170                 175    
 Leu Gly Leu Asp Gln Tyr Ile Ile Lys Arg Phe Asp Gly Lys Thr Glu
             180                 185                 190        
 Lys Ile Ser Gln Glu Arg Glu Lys Phe Ala Asp Glu Gly Ser Ile Phe
         195                 200                 205            
 Tyr Thr Leu Gly Glu Cys Gly Leu Ile Ser Phe Ser Asp Tyr Ile Phe
     210                 215                 220                
 Leu Thr Thr Val Leu Ser Thr Pro Gln Arg Asn Phe Glu Ile Ala Phe
 225                 230                 235                 240
 Lys Met Phe Asp Leu Asn Gly Asp Gly Glu Val Asp Met Glu Glu Phe
                 245                 250                 255    
 Glu Gln Val Gln Ser Ile Ile Arg Ser Gln Thr Ser Met Gly Met Arg
             260                 265                 270        
 His Arg Asp Arg Pro Thr Thr Gly Asn Thr Leu Lys Ser Gly Leu Cys
         275                 280                 285            
 Ser Ala Leu Thr Thr Tyr Phe Phe Gly Ala Asp Leu Lys Gly Lys Leu
     290                 295                 300                
 Thr Ile Lys Asn Phe Leu Glu Phe Gln Arg Lys Leu Gln His Asp Val
 305                 310                 315                 320
 Leu Lys Leu Glu Phe Glu Arg His Asp Pro Val Asp Gly Arg Ile Thr
                 325                 330                 335    
 Glu Arg Gln Phe Gly Gly Met Leu Leu Ala Tyr Ser Gly Val Gln Ser
             340                 345                 350        
 Lys Lys Leu Thr Ala Met Gln Arg Gln Leu Lys Lys His Phe Lys Glu
         355                 360                 365            
 Gly Lys Gly Leu Thr Phe Gln Glu Val Glu Asn Phe Phe Thr Phe Leu
     370                 375                 380                
 Lys Asn Ile Asn Asp Val Asp Thr Ala Leu Ser Phe Tyr His Met Ala
 385                 390                 395                 400
 Gly Ala Ser Leu Asp Lys Val Thr Met Gln Gln Val Ala Arg Thr Val
                 405                 410                 415    
 Ala Lys Val Glu Leu Ser Asp His Val Cys Asp Val Val Phe Ala Leu
             420                 425                 430        
 Phe Asp Cys Asp Gly Asn Gly Glu Leu Ser Asn Lys Glu Phe Val Ser
         435                 440                 445            
 Ile Met Lys Gln Arg Leu Met Arg Gly Leu Glu Lys Pro Lys Asp Met
     450                 455                 460                
 Gly Phe Thr Arg Leu Met Gln Ala Met Trp Lys Cys Ala Gln Glu Thr
 465                 470                 475                 480
 Ala Trp Asp Phe Ala Leu Pro Lys Gln
                 485                



      <210> 2893
      <211> 202
      <212> PRT
      <213> Homo sapiens


      <400> 2893
 Arg Ala Arg Thr Lys Cys Ala Tyr Val Lys Arg Asp Val Cys Arg Met
   1               5                  10                  15    
 Thr Ser Leu Thr Pro Gly Cys Arg Tyr Ser Val Arg Val Ser Pro Gln
              20                  25                  30        
 Met Ala Asn Arg Ile Val Asp Ser Ala Arg Ser Ile Leu Asn Lys Phe
          35                  40                  45            
 Ile Pro Asp Ile Tyr Ile Tyr Thr Asp His Met Lys Gly Val Asn Ser
      50                  55                  60                
 Gly Lys Ser Pro Gly Phe Gly Leu Ser Leu Val Ala Glu Thr Thr Ser
  65                  70                  75                  80
 Gly Thr Phe Leu Ser Ala Glu Leu Ala Ser Asn Pro Gln Gly Gln Gly
                  85                  90                  95    
 Ala Ala Val Leu Pro Glu Asp Leu Gly Arg Asn Cys Ala Arg Leu Leu
             100                 105                 110        
 Leu Glu Glu Ile Tyr Arg Gly Gly Cys Val Tyr Ser Thr Asn Gln Ser
         115                 120                 125            
 Leu Ala Leu Leu Leu Met Thr Leu Gly Gln Gln Asp Val Ser Lys Val
     130                 135                 140                
 Leu Leu Gly Pro Leu Ser Pro Tyr Thr Ile Glu Phe Leu Arg His Leu
 145                 150                 155                 160
 Lys Ser Phe Phe Gln Ile Met Phe Lys Ile Glu Thr Lys Pro Cys Gly
                 165                 170                 175    
 Glu Glu Leu Lys Gly Gly Asp Lys Val Leu Met Thr Cys Val Gly Ile
             180                 185                 190        
 Gly Phe Ser Asn Leu Ser Lys Thr Leu Lys
         195                 200        



      <210> 2894
      <211> 119
      <212> PRT
      <213> Homo sapiens

      <220>
      <221> misc_feature
      <222> (1)...(119)
      <223> Xaa = any amino acid or symbol as shown in the table 8 as set forth in Example 2


      <400> 2894
 Ile Pro Trp Met Gly Thr Glu Arg Thr Arg Ala Ser Ala Gln Arg Asp
   1               5                  10                  15    
 Val Ala Gly Pro Ala Arg Asn Pro Ala Cys Pro Leu Pro Glu Gln Cys
              20                  25                  30        
 Phe Pro Gly Pro Ala Glu Trp Thr Gly Pro Leu Thr Pro Pro Gly Ser
          35                  40                  45            
 Cys Xaa Leu Arg Pro Gly Glu Arg Glu Arg His Gly Pro Gly Cys Trp
      50                  55                  60                
 Gly Pro Arg Glu Arg Leu Ser Ser Gly Gln Thr His Pro Pro Ser Pro
  65                  70                  75                  80
 Gln Gly Cys Ala Asn Thr Cys Pro Cys His Lys His Gln Gln Glu Leu
                  85                  90                  95    
 Leu Ala Gly Gly Val Ala Val Phe Tyr Lys Leu Phe Tyr Arg Tyr Gly
             100                 105                 110        
 Asn Ser Pro Lys Trp Asp Leu
         115                



      <210> 2895
      <211> 145
      <212> PRT
      <213> Homo sapiens


      <400> 2895
 Val Pro Gly Asp Pro Ala Met Val Arg Ala Gly Ala Val Gly Ala His
   1               5                  10                  15    
 Leu Pro Ala Ser Gly Leu Asp Ile Phe Gly Asp Leu Lys Lys Met Asn
              20                  25                  30        
 Lys Arg Gln Leu Tyr Tyr Gln Val Leu Asn Phe Ala Met Ile Val Ser
          35                  40                  45            
 Ser Ala Leu Met Ile Trp Lys Gly Leu Ile Val Leu Thr Gly Ser Glu
      50                  55                  60                
 Ser Pro Ile Val Val Val Leu Ser Gly Ser Met Glu Pro Ala Phe His
  65                  70                  75                  80
 Arg Gly Asp Leu Leu Phe Leu Thr Asn Phe Arg Glu Asp Pro Ile Arg
                  85                  90                  95    
 Ala Gly Glu Ile Val Val Phe Lys Val Glu Gly Arg Asp Ile Pro Ile
             100                 105                 110        
 Val His Arg Val Ile Lys Val His Glu Lys Asp Asn Gly Asp Ile Lys
         115                 120                 125            
 Phe Leu Thr Lys Gly Asp Asn Asn Glu Gly Asp Asp Arg Gly Ser Tyr
     130                 135                 140                
 Lys
 145



      <210> 2896
      <211> 46
      <212> PRT
      <213> Homo sapiens

      <220>
      <221> misc_feature
      <222> (1)...(46)
      <223> Xaa = any amino acid or symbol as shown in the table 8 as set forth in Example 2


      <400> 2896
 Asn Val Ser Arg Cys Arg Ser Arg Cys Glu Arg Glu Thr His Glu Leu
   1               5                  10                  15    
 Leu Ala Asp Lys Glu Arg Ser Val Cys Ser Glu Cys Ser Ser Gln Arg
              20                  25                  30        
 Lys Xaa Arg Phe His Lys Thr Gly Tyr Gln Lys Pro Glu Pro
          35                  40                  45    



      <210> 2897
      <211> 3173
      <212> PRT
      <213> Homo sapiens


      <400> 2897
 Gly Arg Phe Leu Ser Lys Leu Phe Phe Ser Ile Ser Ser Gln Lys Thr
   1               5                  10                  15    
 Cys Leu His Leu His Gly Ile Phe Pro Tyr Leu Tyr Val Pro Tyr Asp
              20                  25                  30        
 Gly Tyr Gly Gln Gln Pro Glu Ser Tyr Leu Ser Gln Met Ala Phe Ser
          35                  40                  45            
 Ile Asp Arg Ala Leu Asn Val Ala Leu Gly Asn Pro Ser Ser Thr Ala
      50                  55                  60                
 Gln His Val Phe Lys Val Ser Leu Val Ser Gly Met Pro Phe Tyr Gly
  65                  70                  75                  80
 Tyr His Glu Lys Glu Arg His Phe Met Lys Ile Tyr Leu Tyr Asn Pro
                  85                  90                  95    
 Thr Met Val Lys Arg Ile Cys Glu Leu Leu Gln Ser Gly Ala Ile Met
             100                 105                 110        
 Asn Lys Phe Tyr Gln Pro His Glu Ala His Ile Pro Tyr Leu Leu Gln
         115                 120                 125            
 Leu Phe Ile Asp Tyr Asn Leu Tyr Gly Met Asn Leu Ile Asn Leu Ala
     130                 135                 140                
 Ala Val Lys Phe Arg Lys Ala Arg Arg Lys Ser Asn Thr Leu His Ala
 145                 150                 155                 160
 Thr Gly Ser Cys Lys Asn His Leu Ser Gly Asn Ser Leu Ala Asp Thr
                 165                 170                 175    
 Leu Phe Arg Trp Glu Gln Asp Glu Ile Pro Ser Ser Leu Ile Leu Glu
             180                 185                 190        
 Gly Val Glu Pro His Ser Thr Cys Glu Leu Gln Val Asp Ala Val Ala
         195                 200                 205            
 Ala Asp Ile Leu Asn Arg Leu Asp Ile Glu Ala Gln Ile Gly Gly Asn
     210                 215                 220                
 Pro Gly Leu Gln Ala Ile Trp Glu Asp Glu Lys Gln Arg Arg Arg Asn
 225                 230                 235                 240
 Arg Asn Glu Thr Ser Gln Met Ser Gln Pro Glu Ser Gln Asp His Arg
                 245                 250                 255    
 Phe Val Pro Ala Thr Glu Ser Glu Lys Lys Phe Gln Lys Arg Leu Gln
             260                 265                 270        
 Glu Ile Leu Lys Gln Asn Asp Phe Ser Val Thr Leu Ser Gly Ser Val
         275                 280                 285            
 Asp Tyr Ser Asp Gly Ser Gln Glu Phe Ser Ala Glu Leu Thr Leu His
     290                 295                 300                
 Ser Glu Val Leu Ser Pro Glu Met Leu Gln Cys Thr Pro Ala Asn Met
 305                 310                 315                 320
 Val Glu Val His Lys Asp Lys Glu Ser Ser Lys Gly His Thr Arg His
                 325                 330                 335    
 Lys Val Glu Glu Ala Leu Ile Asn Glu Glu Ala Ile Leu Asn Leu Met
             340                 345                 350        
 Glu Asn Ser Gln Thr Phe Gln Pro Leu Thr Gln Arg Leu Ser Glu Ser
         355                 360                 365            
 Pro Val Phe Met Asp Ser Ser Pro Asp Glu Ala Leu Val His Leu Leu
     370                 375                 380                
 Ala Gly Leu Glu Ser Asp Gly Tyr Arg Gly Glu Arg Asn Arg Met Pro
 385                 390                 395                 400
 Ser Pro Cys Arg Ser Phe Gly Asn Asn Lys Tyr Pro Gln Asn Ser Asp
                 405                 410                 415    
 Asp Glu Glu Asn Glu Pro Gln Ile Glu Lys Glu Glu Met Glu Leu Ser
             420                 425                 430        
 Leu Val Met Ser Gln Arg Trp Asp Ser Asn Ile Glu Glu His Cys Ala
         435                 440                 445            
 Lys Lys Arg Ser Leu Cys Arg Asn Thr His Arg Ser Ser Thr Glu Asp
     450                 455                 460                
 Asp Asp Ser Ser Ser Gly Glu Glu Met Glu Trp Ser Asp Asn Ser Leu
 465                 470                 475                 480
 Leu Leu Ala Ser Leu Ser Ile Pro Gln Leu Asp Gly Thr Ala Asp Glu
                 485                 490                 495    
 Asn Ser Asp Asn Pro Leu Asn Asn Glu Asn Ser Arg Thr His Ser Ser
             500                 505                 510        
 Val Ile Ala Thr Ser Lys Leu Ser Val Lys Pro Ser Ile Phe His Lys
         515                 520                 525            
 Asp Ala Ala Thr Leu Glu Pro Ser Ser Ser Ala Lys Ile Thr Phe Gln
     530                 535                 540                
 Cys Lys His Thr Ser Ala Leu Ser Ser His Val Leu Asn Lys Glu Asp
 545                 550                 555                 560
 Leu Ile Glu Asp Leu Ser Gln Thr Asn Lys Asn Thr Glu Lys Gly Leu
                 565                 570                 575    
 Asp Asn Ser Val Thr Ser Phe Thr Asn Glu Ser Thr Tyr Ser Met Lys
             580                 585                 590        
 Tyr Pro Gly Ser Leu Ser Ser Thr Val His Ser Glu Asn Ser His Lys
         595                 600                 605            
 Glu Asn Ser Lys Lys Glu Ile Leu Pro Val Ser Ser Cys Glu Ser Ser
     610                 615                 620                
 Ile Phe Asp Tyr Glu Glu Asp Ile Pro Ser Val Thr Arg Gln Val Pro
 625                 630                 635                 640
 Ser Arg Lys Tyr Thr Asn Ile Arg Lys Ile Glu Lys Asp Ser Pro Phe
                 645                 650                 655    
 Ile His Met His Arg His Pro Asn Glu Asn Thr Leu Gly Lys Asn Ser
             660                 665                 670        
 Phe Asn Phe Ser Asp Leu Asn His Ser Lys Asn Lys Val Ser Ser Glu
         675                 680                 685            
 Gly Asn Glu Lys Gly Asn Ser Thr Ala Leu Ser Ser Leu Phe Pro Ser
     690                 695                 700                
 Ser Phe Thr Glu Asn Cys Glu Leu Leu Ser Cys Ser Gly Glu Asn Arg
 705                 710                 715                 720
 Thr Met Val His Ser Leu Asn Ser Thr Ala Asp Glu Ser Gly Leu Asn
                 725                 730                 735    
 Lys Leu Lys Ile Arg Tyr Glu Glu Phe Gln Glu His Lys Thr Glu Lys
             740                 745                 750        
 Pro Ser Leu Ser Gln Gln Ala Ala His Tyr Met Phe Phe Pro Ser Val
         755                 760                 765            
 Val Leu Ser Asn Cys Leu Thr Arg Pro Gln Lys Leu Ser Pro Val Thr
     770                 775                 780                
 Tyr Lys Leu Gln Pro Gly Asn Lys Pro Ser Arg Leu Lys Leu Asn Lys
 785                 790                 795                 800
 Arg Lys Leu Ala Gly His Gln Glu Thr Ser Thr Lys Ser Ser Glu Thr
                 805                 810                 815    
 Gly Ser Thr Lys Asp Asn Phe Ile Gln Asn Asn Pro Cys Asn Ser Asn
             820                 825                 830        
 Pro Glu Lys Asp Asn Ala Leu Ala Ser Asp Leu Thr Lys Thr Thr Arg
         835                 840                 845            
 Gly Ala Phe Glu Asn Lys Thr Pro Thr Asp Gly Phe Ile Asp Cys His
     850                 855                 860                
 Phe Gly Asp Gly Thr Leu Glu Thr Glu Gln Ser Phe Gly Leu Tyr Gly
 865                 870                 875                 880
 Asn Lys Tyr Thr Leu Arg Ala Lys Arg Lys Val Asn Tyr Glu Thr Glu
                 885                 890                 895    
 Asp Ser Glu Ser Ser Phe Val Thr His Asn Ser Lys Ile Ser Leu Pro
             900                 905                 910        
 His Pro Met Glu Ile Gly Glu Ser Leu Asp Gly Thr Leu Lys Ser Arg
         915                 920                 925            
 Lys Arg Arg Lys Met Ser Lys Lys Leu Pro Pro Val Ile Ile Lys Tyr
     930                 935                 940                
 Ile Ile Ile Asn Arg Phe Arg Gly Arg Lys Asn Met Leu Val Lys Leu
 945                 950                 955                 960
 Gly Lys Ile Asp Ser Lys Glu Lys Gln Val Ile Leu Thr Glu Glu Lys
                 965                 970                 975    
 Met Glu Leu Tyr Lys Lys Leu Ala Pro Leu Lys Asp Phe Trp Pro Lys
             980                 985                 990        
 Val Pro Asp Ser Pro Ala Thr Lys Tyr Pro Ile Tyr Pro Leu Thr Pro
         995                1000                1005            
 Lys Lys Ser His Arg Arg Lys Ser Lys His Lys Ser Ala Lys Lys Lys
    1010                1015                1020                
 Thr Gly Lys Gln Gln Arg Thr Asn Asn Glu Asn Ile Lys Arg Thr Leu
1025                1030                1035                1040
 Ser Phe Arg Lys Lys Arg Ser His Ala Ile Leu Ser Pro Pro Ser Pro
                1045                1050                1055    
 Ser Tyr Asn Ala Glu Thr Glu Asp Cys Asp Leu Asn Tyr Ser Asp Val
            1060                1065                1070        
 Met Ser Lys Leu Gly Phe Leu Ser Glu Arg Ser Thr Ser Pro Ile Asn
        1075                1080                1085            
 Ser Ser Pro Pro Arg Cys Trp Ser Pro Thr Asp Pro Arg Ala Glu Glu
    1090                1095                1100                
 Ile Met Ala Ala Ala Glu Lys Glu Ala Met Leu Phe Lys Gly Pro Asn
1105                1110                1115                1120
 Val Cys Lys Lys Thr Val Asn Ser Arg Ile Gly Lys Thr Ser Arg Ala
                1125                1130                1135    
 Arg Ala Gln Ile Lys Lys Ser Lys Ala Lys Leu Ala Asn Pro Ser Ile
            1140                1145                1150        
 Val Thr Lys Lys Arg Asn Lys Arg Asn Gln Thr Asn Lys Leu Val Asp
        1155                1160                1165            
 Asp Gly Lys Lys Lys Pro Arg Ala Lys Gln Lys Thr Asn Glu Lys Gly
    1170                1175                1180                
 Thr Ser Arg Lys His Ile Thr Leu Lys Asp Glu Lys Ile Lys Ser Gln
1185                1190                1195                1200
 Ser Gly Ala Glu Val Lys Phe Val Leu Lys His Gln Asn Val Ser Glu
                1205                1210                1215    
 Phe Ala Ser Ser Ser Gly Gly Ser Gln Leu Leu Phe Lys Gln Lys Asp
            1220                1225                1230        
 Met Pro Leu Met Gly Ser Ala Val Asp His Pro Leu Ser Ala Ser Leu
        1235                1240                1245            
 Pro Thr Gly Ile Asn Ala Gln Gln Lys Leu Ser Gly Cys Phe Ser Ser
    1250                1255                1260                
 Phe Leu Glu Ser Lys Lys Ser Val Asp Leu Gln Thr Phe Pro Ser Ser
1265                1270                1275                1280
 Arg Asp Asp Leu His Pro Ser Val Val Cys Asn Ser Ile Gly Pro Gly
                1285                1290                1295    
 Val Ser Lys Ile Asn Val Gln Arg Pro His Asn Gln Ser Ala Met Phe
            1300                1305                1310        
 Thr Leu Lys Glu Ser Thr Leu Ile Gln Lys Asn Ile Phe Asp Leu Ser
        1315                1320                1325            
 Asn His Leu Ser Gln Val Ala Gln Asn Thr Gln Ile Ser Ser Gly Met
    1330                1335                1340                
 Ser Ser Lys Ile Glu Asp Asn Ala Asn Asn Ile Gln Arg Asn Tyr Leu
1345                1350                1355                1360
 Ser Ser Ile Gly Lys Leu Ser Glu Tyr Arg Asn Ser Leu Glu Ser Lys
                1365                1370                1375    
 Leu Asp Gln Ala Tyr Thr Pro Asn Phe Leu His Cys Lys Asp Ser Gln
            1380                1385                1390        
 Gln Gln Ile Val Cys Ile Ala Glu Gln Ser Lys His Ser Glu Thr Cys
        1395                1400                1405            
 Ser Pro Gly Asn Thr Ala Ser Glu Glu Ser Gln Met Pro Asn Asn Cys
    1410                1415                1420                
 Phe Val Thr Ser Leu Arg Ser Pro Ile Lys Gln Ile Ala Trp Glu Gln
1425                1430                1435                1440
 Lys Gln Arg Gly Phe Ile Leu Asp Met Ser Asn Phe Lys Pro Glu Arg
                1445                1450                1455    
 Val Lys Pro Arg Ser Leu Ser Glu Ala Ile Ser Gln Thr Lys Ala Leu
            1460                1465                1470        
 Ser Gln Cys Lys Asn Arg Asn Val Ser Thr Pro Ser Ala Phe Gly Glu
        1475                1480                1485            
 Gly Gln Ser Gly Leu Ala Val Leu Lys Glu Leu Leu Gln Lys Arg Gln
    1490                1495                1500                
 Gln Glu Ala Gln Asn Ala Asn Thr Thr Gln Asp Pro Leu Ser Asn Lys
1505                1510                1515                1520
 His Gln Pro Asn Lys Asn Ile Ser Gly Ser Leu Glu His Asn Lys Ala
                1525                1530                1535    
 Asn Lys Arg Thr Arg Ser Val Thr Ser Pro Arg Lys Pro Arg Thr Pro
            1540                1545                1550        
 Arg Ser Thr Lys Gln Lys Glu Lys Ile Pro Lys Leu Leu Lys Val Asp
        1555                1560                1565            
 Ser Leu Asn Leu Gln Asn Ser Ser Gln Leu Asp Asn Ser Val Ser Asp
    1570                1575                1580                
 Asp Ser Pro Ile Phe Phe Ser Asp Pro Gly Phe Glu Ser Cys Tyr Ser
1585                1590                1595                1600
 Leu Glu Asp Ser Leu Ser Pro Glu His Asn Tyr Asn Phe Asp Ile Asn
                1605                1610                1615    
 Thr Ile Gly Gln Thr Gly Phe Cys Ser Phe Tyr Ser Gly Ser Gln Phe
            1620                1625                1630        
 Val Pro Ala Asp Gln Asn Leu Pro Gln Lys Phe Leu Ser Asp Ala Val
        1635                1640                1645            
 Gln Asp Leu Phe Pro Gly Gln Ala Ile Glu Lys Asn Glu Phe Leu Ser
    1650                1655                1660                
 His Asp Asn Gln Lys Cys Asp Glu Asp Lys His His Thr Thr Asp Ser
1665                1670                1675                1680
 Ala Ser Trp Ile Arg Ser Gly Thr Leu Ser Pro Glu Ile Phe Glu Lys
                1685                1690                1695    
 Ser Thr Ile Asp Ser Asn Glu Asn Arg Arg His Asn Gln Trp Lys Asn
            1700                1705                1710        
 Ser Phe His Pro Leu Thr Thr Arg Ser Asn Ser Ile Met Asp Ser Phe
        1715                1720                1725            
 Cys Val Gln Gln Ala Glu Asp Cys Leu Ser Glu Lys Ser Arg Leu Asn
    1730                1735                1740                
 Arg Ser Ser Val Ser Lys Glu Val Phe Leu Ser Leu Pro Gln Pro Asn
1745                1750                1755                1760
 Asn Ser Asp Trp Ile Gln Gly His Thr Arg Lys Glu Met Gly Gln Ser
                1765                1770                1775    
 Leu Asp Ser Ala Asn Thr Ser Phe Thr Ala Ile Leu Ser Ser Pro Asp
            1780                1785                1790        
 Gly Glu Leu Val Asp Val Ala Cys Glu Asp Leu Glu Leu Tyr Val Ser
        1795                1800                1805            
 Arg Asn Asn Asp Met Leu Thr Pro Thr Pro Asp Ser Ser Pro Arg Ser
    1810                1815                1820                
 Thr Ser Ser Pro Ser Gln Ser Lys Asn Gly Ser Phe Thr Pro Arg Thr
1825                1830                1835                1840
 Ala Asn Ile Leu Lys Pro Leu Met Ser Pro Pro Ser Arg Glu Glu Ile
                1845                1850                1855    
 Met Ala Thr Leu Leu Asp His Asp Leu Ser Glu Thr Ile Tyr Gln Glu
            1860                1865                1870        
 Pro Phe Cys Ser Asn Pro Ser Asp Val Pro Glu Lys Pro Arg Glu Ile
        1875                1880                1885            
 Gly Gly Arg Leu Leu Met Val Glu Thr Arg Leu Ala Asn Asp Leu Ala
    1890                1895                1900                
 Glu Phe Glu Gly Asp Phe Ser Leu Glu Gly Leu Arg Leu Trp Lys Thr
1905                1910                1915                1920
 Ala Phe Ser Ala Met Thr Gln Asn Pro Arg Pro Gly Ser Pro Leu Arg
                1925                1930                1935    
 Ser Gly Gln Gly Val Val Asn Lys Gly Ser Ser Asn Ser Pro Lys Met
            1940                1945                1950        
 Val Glu Asp Lys Lys Ile Val Ile Met Pro Cys Lys Cys Ala Pro Ser
        1955                1960                1965            
 Arg Gln Leu Val Gln Val Trp Leu Gln Ala Lys Glu Glu Tyr Glu Arg
    1970                1975                1980                
 Ser Lys Lys Leu Pro Lys Thr Lys Pro Thr Gly Val Val Lys Ser Ala
1985                1990                1995                2000
 Glu Asn Phe Ser Ser Ser Val Asn Pro Asp Asp Lys Pro Val Val Pro
                2005                2010                2015    
 Pro Lys Met Asp Val Ser Pro Cys Ile Leu Pro Thr Thr Ala His Thr
            2020                2025                2030        
 Lys Glu Asp Val Asp Asn Ser Gln Ile Ala Leu Gln Ala Pro Thr Thr
        2035                2040                2045            
 Gly Cys Ser Gln Thr Ala Ser Glu Ser Gln Met Leu Pro Pro Val Ala
    2050                2055                2060                
 Ser Ala Ser Asp Pro Glu Lys Asp Glu Asp Asp Asp Asp Asn Tyr Tyr
2065                2070                2075                2080
 Ile Ser Tyr Ser Ser Pro Asp Ser Pro Val Ile Pro Pro Trp Gln Gln
                2085                2090                2095    
 Pro Ile Ser Pro Asp Ser Lys Ala Leu Asn Gly Asp Asp Arg Pro Ser
            2100                2105                2110        
 Ser Pro Val Glu Glu Leu Pro Ser Leu Ala Phe Glu Asn Phe Leu Lys
        2115                2120                2125            
 Pro Ile Lys Asp Gly Ile Gln Lys Ser Pro Cys Ser Glu Pro Gln Glu
    2130                2135                2140                
 Pro Leu Val Ile Ser Pro Ile Asn Thr Arg Ala Arg Thr Gly Lys Cys
2145                2150                2155                2160
 Glu Ser Leu Cys Phe His Ser Thr Pro Ile Ile Gln Arg Lys Leu Leu
                2165                2170                2175    
 Glu Arg Leu Pro Glu Ala Pro Gly Leu Ser Pro Leu Ser Thr Glu Pro
            2180                2185                2190        
 Lys Thr Gln Lys Leu Ser Asn Lys Lys Gly Ser Asn Thr Asp Thr Leu
        2195                2200                2205            
 Arg Arg Val Leu Leu Thr Gln Ala Lys Asn Gln Phe Ala Ala Val Asn
    2210                2215                2220                
 Thr Pro Gln Lys Glu Thr Ser Gln Ile Asp Gly Pro Ser Leu Asn Asn
2225                2230                2235                2240
 Thr Tyr Gly Phe Lys Val Ser Ile Gln Asn Leu Gln Glu Ala Lys Ala
                2245                2250                2255    
 Leu His Glu Ile Gln Asn Leu Thr Leu Ile Ser Val Glu Leu His Ala
            2260                2265                2270        
 Arg Thr Arg Arg Asp Leu Glu Pro Asp Pro Glu Phe Asp Pro Ile Cys
        2275                2280                2285            
 Ala Leu Phe Tyr Cys Ile Ser Ser Asp Thr Pro Leu Pro Asp Thr Glu
    2290                2295                2300                
 Lys Thr Glu Leu Thr Gly Val Ile Val Ile Asp Lys Asp Lys Thr Val
2305                2310                2315                2320
 Phe Ser Gln Asp Ile Arg Tyr Gln Thr Pro Leu Leu Ile Arg Ser Gly
                2325                2330                2335    
 Ile Thr Gly Leu Glu Val Thr Tyr Ala Ala Asp Glu Lys Ala Leu Phe
            2340                2345                2350        
 His Glu Ile Ala Asn Ile Ile Lys Arg Tyr Asp Pro Asp Ile Leu Leu
        2355                2360                2365            
 Gly Tyr Glu Ile Gln Met His Ser Trp Gly Tyr Leu Leu Gln Arg Ala
    2370                2375                2380                
 Ala Ala Leu Ser Ile Asp Leu Cys Arg Met Ile Ser Arg Val Pro Asp
2385                2390                2395                2400
 Asp Lys Ile Glu Asn Arg Phe Ala Ala Glu Arg Asp Glu Tyr Gly Ser
                2405                2410                2415    
 Tyr Thr Met Ser Glu Ile Asn Ile Val Gly Arg Ile Thr Leu Asn Leu
            2420                2425                2430        
 Trp Arg Ile Met Arg Asn Glu Val Ala Leu Thr Asn Tyr Thr Phe Glu
        2435                2440                2445            
 Asn Val Ser Phe His Val Leu His Gln Arg Phe Pro Leu Phe Thr Phe
    2450                2455                2460                
 Arg Val Leu Ser Asp Trp Phe Asp Asn Lys Thr Asp Leu Tyr Arg Trp
2465                2470                2475                2480
 Lys Met Val Asp His Tyr Val Ser Arg Val Arg Gly Asn Leu Gln Met
                2485                2490                2495    
 Leu Glu Gln Leu Asp Leu Ile Gly Lys Thr Ser Glu Met Ala Arg Leu
            2500                2505                2510        
 Phe Gly Ile Gln Phe Leu His Val Leu Thr Arg Gly Ser Gln Tyr Arg
        2515                2520                2525            
 Val Glu Ser Met Met Leu Arg Ile Ala Lys Pro Met Asn Tyr Ile Pro
    2530                2535                2540                
 Val Thr Pro Ser Val Gln Gln Arg Ser Gln Met Arg Ala Pro Gln Cys
2545                2550                2555                2560
 Val Pro Leu Ile Met Glu Pro Glu Ser Arg Phe Tyr Ser Asn Ser Val
                2565                2570                2575    
 Leu Val Leu Asp Phe Gln Ser Leu Tyr Pro Ser Ile Val Ile Ala Tyr
            2580                2585                2590        
 Asn Tyr Cys Phe Ser Thr Cys Leu Gly His Val Glu Asn Leu Gly Lys
        2595                2600                2605            
 Tyr Asp Glu Phe Lys Phe Gly Cys Thr Ser Leu Arg Val Pro Pro Asp
    2610                2615                2620                
 Leu Leu Tyr Gln Val Arg His Asp Ile Thr Val Ser Pro Asn Gly Val
2625                2630                2635                2640
 Ala Phe Val Lys Pro Ser Val Arg Lys Gly Val Leu Pro Arg Met Leu
                2645                2650                2655    
 Glu Glu Ile Leu Lys Thr Arg Phe Met Val Lys Gln Ser Met Lys Ala
            2660                2665                2670        
 Tyr Lys Gln Asp Arg Ala Leu Ser Arg Met Leu Asp Ala Arg Gln Leu
        2675                2680                2685            
 Gly Leu Lys Leu Ile Ala Asn Val Thr Phe Gly Tyr Thr Ser Ala Asn
    2690                2695                2700                
 Phe Ser Gly Arg Met Pro Cys Ile Glu Val Gly Asp Ser Ile Val His
2705                2710                2715                2720
 Lys Ala Arg Glu Thr Leu Glu Arg Ala Ile Lys Leu Val Asn Asp Thr
                2725                2730                2735    
 Lys Lys Trp Gly Ala Arg Val Val Tyr Gly Asp Thr Asp Ser Met Phe
            2740                2745                2750        
 Val Leu Leu Lys Gly Ala Thr Lys Glu Gln Ser Phe Lys Ile Gly Gln
        2755                2760                2765            
 Glu Ile Ala Glu Ala Val Thr Ala Thr Asn Pro Lys Pro Val Lys Leu
    2770                2775                2780                
 Lys Phe Glu Lys Val Tyr Leu Pro Cys Val Leu Gln Thr Lys Lys Arg
2785                2790                2795                2800
 Tyr Val Gly Tyr Met Tyr Glu Thr Leu Asp Gln Lys Asp Pro Val Phe
                2805                2810                2815    
 Asp Ala Lys Gly Ile Glu Thr Val Arg Arg Asp Ser Cys Pro Ala Val
            2820                2825                2830        
 Ser Lys Ile Leu Glu Arg Ser Leu Lys Leu Leu Phe Glu Thr Arg Asp
        2835                2840                2845            
 Ile Ser Leu Ile Lys Gln Tyr Val Gln Arg Gln Cys Met Lys Leu Leu
    2850                2855                2860                
 Glu Gly Lys Ala Ser Ile Gln Asp Phe Ile Phe Ala Lys Glu Tyr Arg
2865                2870                2875                2880
 Gly Ser Phe Ser Tyr Lys Pro Gly Ala Cys Val Pro Ala Leu Glu Leu
                2885                2890                2895    
 Thr Arg Lys Met Leu Thr Tyr Asp Arg Arg Ser Glu Pro Gln Val Gly
            2900                2905                2910        
 Glu Arg Val Pro Tyr Val Ile Ile Tyr Gly Thr Pro Gly Val Pro Leu
        2915                2920                2925            
 Ile Gln Leu Val Arg Arg Pro Val Glu Val Leu Gln Asp Pro Thr Leu
    2930                2935                2940                
 Arg Leu Asn Ala Thr Tyr Tyr Ile Thr Lys Gln Ile Leu Pro Pro Leu
2945                2950                2955                2960
 Ala Arg Ile Phe Ser Leu Ile Gly Ile Asp Val Phe Ser Trp Tyr His
                2965                2970                2975    
 Glu Leu Pro Arg Gly Phe Ile Ala Ala Leu Phe Thr Ile Ala Lys Thr
            2980                2985                2990        
 Trp Asn Gln Pro Lys Cys Pro Ser Met Ile Asp Trp Ile Lys Lys Met
        2995                3000                3005            
 Trp His Ile Tyr Thr Met Glu Tyr Tyr Ala Ala Ile Lys Lys Asp Glu
    3010                3015                3020                
 Phe Met Ser Phe Ala Gly Thr Trp Met Lys Leu Glu Thr Ile Ile Leu
3025                3030                3035                3040
 Ser Lys Leu Ser Gln Gly Gln Lys Thr Lys His Arg Leu Phe Ser Leu
                3045                3050                3055    
 Ile Ile His Lys Ala Thr Ser Pro Ser Arg Ser Glu Pro Glu Gly Arg
            3060                3065                3070        
 Lys Gly Thr Ile Ser Gln Tyr Phe Thr Thr Leu His Cys Pro Val Cys
        3075                3080                3085            
 Asp Asp Leu Thr Gln His Gly Ile Cys Ser Lys Cys Arg Ser Gln Pro
    3090                3095                3100                
 Gln His Val Ala Val Ile Leu Asn Gln Glu Ile Arg Glu Leu Glu Arg
3105                3110                3115                3120
 Gln Gln Glu Gln Leu Val Lys Ile Cys Lys Asn Cys Thr Gly Cys Phe
                3125                3130                3135    
 Asp Arg His Ile Pro Cys Val Ser Leu Asn Cys Pro Val Leu Phe Lys
            3140                3145                3150        
 Leu Ser Arg Val Asn Arg Glu Leu Ser Lys Ala Pro Tyr Leu Arg Gln
        3155                3160                3165            
 Leu Leu Asp Gln Phe
    3170            



      <210> 2898
      <211> 208
      <212> PRT
      <213> Homo sapiens

      <220>
      <221> misc_feature
      <222> (1)...(208)
      <223> Xaa = any amino acid or symbol as shown in the table 8 as set forth in Example 2


      <400> 2898
 Ser Val Gly Ala Leu Asp Thr Phe Ile Ala Ala Val Tyr Glu His Ala
   1               5                  10                  15    
 Val Ile Leu Pro Asn Arg Ala Glu Thr Pro Val Ser Lys Glu Glu Ala
              20                  25                  30        
 Leu Leu Leu Met Asn Lys Asn Ile Asp Val Leu Glu Lys Ala Val Lys
          35                  40                  45            
 Leu Ala Ala Lys Gln Gly Ala His Ile Ile Val Thr Pro Glu Asp Gly
      50                  55                  60                
 Ile Tyr Gly Trp Ile Phe Thr Arg Glu Ser Ile Tyr Pro Tyr Leu Glu
  65                  70                  75                  80
 Asp Ile Pro Asp Pro Gly Val Asn Trp Ile Pro Cys Arg Asp Pro Trp
                  85                  90                  95    
 Arg Asn His Xaa Asn Ile Val Ser Leu Arg Lys Cys Leu Leu Asn Arg
             100                 105                 110        
 Phe Gly Asn Thr Pro Val Gln Gln Arg Leu Ser Cys Leu Ala Lys Asp
         115                 120                 125            
 Asn Ser Ile Tyr Val Val Ala Asn Ile Gly Asp Lys Lys Pro Cys Asn
     130                 135                 140                
 Ala Ser Asp Ser Gln Cys Pro Pro Asp Gly Arg Tyr Gln Tyr Asn Thr
 145                 150                 155                 160
 Asp Val Val Phe Asp Ser Gln Gly Lys Leu Leu Ala Arg Tyr His Lys
                 165                 170                 175    
 Tyr Asn Leu Phe Ala Pro Glu Ile Gln Phe Asp Phe Pro Lys Asp Ser
             180                 185                 190        
 Glu Leu Val Thr Phe Asp Thr Pro Phe Gly Lys Ile Gly Ile Ile Thr
         195                 200                 205            





      <210> 2899
      <211> 716
      <212> PRT
      <213> Homo sapiens


      <400> 2899
 Met Asp Thr Phe Leu Asp Thr Tyr Thr Leu Pro Arg Leu Asn Gln Glu
   1               5                  10                  15    
 Glu Val Glu Ser Leu Asn Arg Pro Ile Thr Gly Ser Glu Ile Val Ala
              20                  25                  30        
 Ile Ile Asn Ser Leu Pro Thr Lys Lys Ser Pro Gly Pro Asp Gly Phe
          35                  40                  45            
 Thr Ala Glu Phe Tyr Gln Arg Tyr Lys Glu Glu Leu Val Pro Phe Leu
      50                  55                  60                
 Leu Lys Leu Phe Gln Ser Ile Glu Lys Glu Gly Ile Leu Pro Asn Ser
  65                  70                  75                  80
 Phe Tyr Glu Ala Ser Ile Ile Leu Ile Pro Lys Pro Gly Arg Asp Thr
                  85                  90                  95    
 Thr Lys Lys Glu Asn Phe Arg Pro Ile Ser Leu Met Asn Ile Asp Ala
             100                 105                 110        
 Lys Ile Leu Asn Lys Ile Leu Ala Asn Arg Ile Gln Gln His Ile Lys
         115                 120                 125            
 Lys Leu Ile His His Asp Gln Val Gly Phe Ile Pro Gly Met Gln Gly
     130                 135                 140                
 Trp Phe Asn Ile Arg Lys Ser Ile Asn Val Ile Gln His Ile Asn Arg
 145                 150                 155                 160
 Ala Lys Asp Lys Asn His Met Ile Ile Ser Ile Asp Ala Glu Lys Ala
                 165                 170                 175    
 Phe Asp Lys Ile Gln Gln Pro Phe Met Leu Lys Thr Leu Asn Lys Leu
             180                 185                 190        
 Gly Ile Asp Gly Thr Tyr Phe Lys Ile Ile Arg Ala Ile Tyr Asp Lys
         195                 200                 205            
 Pro Thr Ala Asn Ile Ile Leu Asn Gly Gln Lys Leu Glu Ala Phe Pro
     210                 215                 220                
 Leu Lys Thr Gly Thr Arg Gln Gly Cys Pro Leu Ser Pro Leu Leu Phe
 225                 230                 235                 240
 Asn Ile Val Leu Glu Val Leu Ala Arg Ala Ile Arg Gln Glu Lys Glu
                 245                 250                 255    
 Ile Lys Gly Ile Gln Leu Gly Lys Glu Glu Val Lys Leu Ser Leu Phe
             260                 265                 270        
 Ala Asp Asp Met Ile Val Tyr Leu Glu Asn Pro Ile Val Ser Ala Gln
         275                 280                 285            
 Asn Leu Leu Lys Leu Ile Ser Asn Phe Ser Lys Val Ser Gly Tyr Lys
     290                 295                 300                
 Ile Asn Val Gln Lys Ser Gln Ala Phe Leu Tyr Thr Asn Asn Arg Gln
 305                 310                 315                 320
 Thr Glu Ser Gln Ile Met Gly Glu Leu Pro Phe Thr Ile Ala Ser Lys
                 325                 330                 335    
 Arg Ile Lys Tyr Leu Gly Ile Gln Leu Thr Arg Asp Val Lys Asp Leu
             340                 345                 350        
 Phe Lys Glu Asn Tyr Lys Pro Leu Leu Lys Glu Ile Lys Glu Glu Thr
         355                 360                 365            
 Asn Lys Trp Lys Asn Ile Pro Cys Ser Trp Val Gly Arg Ile Asn Ile
     370                 375                 380                
 Val Lys Met Ala Ile Leu Pro Lys Leu Ile Gly Asn Cys Ser Lys Ile
 385                 390                 395                 400
 Ser Gly Tyr Lys Ile Asn Val Gln Lys Ser Gln Ala Phe Leu Tyr Thr
                 405                 410                 415    
 Asn Asn Arg Gln Thr Glu Ser Gln Ile Met Ser Glu Leu Ala Phe Thr
             420                 425                 430        
 Ile Ala Ser Lys Lys Ile Lys Tyr Leu Gly Ile Gln Leu Thr Arg Asp
         435                 440                 445            
 Val Lys Asp Leu Phe Lys Glu Asn Tyr Lys Pro Leu Leu Asn Glu Ile
     450                 455                 460                
 Lys Glu Asp Thr Asn Lys Trp Lys Asn Ile Pro Cys Ser Trp Val Gly
 465                 470                 475                 480
 Arg Ile Asn Ile Val Lys Met Ala Ile Leu Pro Lys Ser Arg Val Cys
                 485                 490                 495    
 Asp Leu Arg Tyr Leu His Trp Ile Tyr Gly Ser Val Ser Tyr Gly Lys
             500                 505                 510        
 Gly Asn Ala Trp Ile Thr Arg Lys Arg Ser Thr Thr Gln Lys Trp Thr
         515                 520                 525            
 Gly Ala Ala Leu Gln Pro Leu Ser Arg Thr Ser Leu Lys Asp Thr Gly
     530                 535                 540                
 Glu Gly Glu Ser Ser Gln Trp Ala Glu Leu Arg Ala Val Tyr Leu Leu
 545                 550                 555                 560
 Val His Phe Ala Trp Lys Glu Lys Trp Pro His Val Trp Leu Tyr Thr
                 565                 570                 575    
 Asp Ser Trp Ala Val Ser Ser Gly Ser Ala Gly Trp Ser Gly Thr Trp
             580                 585                 590        
 Lys Lys His Asp Trp Lys Ile Gly Asp Lys Glu Ile Trp Arg Arg Ala
         595                 600                 605            
 Ser Tyr Leu Val Ala Asp Tyr Ile Gly Pro Leu Pro Ser Trp Lys Gly
     610                 615                 620                
 Gln Arg Phe Val Leu Thr Gly Ile Asp Thr Tyr Ser Gly Tyr Gly Phe
 625                 630                 635                 640
 Ala Tyr Pro Ala Cys Asn Ala Ser Ala Lys Thr Thr Ile Arg Gly Phe
                 645                 650                 655    
 Met Glu Cys Leu Ile His His His Gly Ile Pro His Ser Ile Ala Ser
             660                 665                 670        
 Asp Gln Gly Thr His Phe Met Ala Lys Glu Val Gln Gln Trp Ala His
         675                 680                 685            
 Ser His Gly Ile His Arg Ser Tyr His Val Leu His His Pro Glu Ala
     690                 695                 700                
 Ala Gly Leu Ile Glu Arg Trp Asn Gly Leu Leu Lys
 705                 710                 715    



      <210> 2900
      <211> 91
      <212> PRT
      <213> Homo sapiens

      <220>
      <221> misc_feature
      <222> (1)...(91)
      <223> Xaa = any amino acid or symbol as shown in the table 8 as set forth in Example 2


      <400> 2900
 Ile Arg Cys Phe Thr Tyr Ser Pro Ala Pro Gly Tyr Phe Pro Arg Phe
   1               5                  10                  15    
 Arg Ala Val Ile Ile Lys Leu Cys Asn Gly Asp Ser Leu Arg His Phe
              20                  25                  30        
 Met Thr Ser Val Tyr Ala Leu Gln Glu Ala Ala Ala Glu Val Arg His
          35                  40                  45            
 Thr Leu Val Thr Leu Arg Gln Leu Val Thr Leu Tyr Asp Pro Val Asp
      50                  55                  60                
 Phe Gln Arg Asp Asp Ala Xaa Ala Ile Arg Ala Tyr Asp Thr Asp Thr
  65                  70                  75                  80
 Gly Ile Arg Ile Asn Ala Trp His Thr Asp Trp
                  85                  90    



      <210> 2901
      <211> 285
      <212> PRT
      <213> Homo sapiens


      <400> 2901
 Pro Val Cys Thr Ala Leu Thr Pro Gly Arg Met Thr Asp Asp Lys Asp
   1               5                  10                  15    
 Val Leu Arg Asp Val Trp Phe Gly Arg Ile Pro Thr Cys Phe Thr Leu
              20                  25                  30        
 Tyr Gln Asp Glu Ile Thr Glu Arg Glu Ala Glu Pro Tyr Tyr Leu Leu
          35                  40                  45            
 Leu Pro Arg Val Ser Tyr Leu Thr Leu Val Thr Asp Lys Val Lys Lys
      50                  55                  60                
 His Phe Gln Lys Val Met Arg Gln Glu Asp Ile Ser Glu Ile Trp Phe
  65                  70                  75                  80
 Glu Tyr Glu Gly Thr Pro Leu Lys Trp His Tyr Pro Ile Gly Leu Leu
                  85                  90                  95    
 Phe Asp Leu Leu Ala Ser Ser Ser Ala Leu Pro Trp Asn Ile Thr Val
             100                 105                 110        
 His Phe Lys Ser Phe Pro Glu Lys Asp Leu Leu His Cys Pro Ser Lys
         115                 120                 125            
 Asp Ala Ile Glu Ala His Phe Met Ser Cys Met Lys Glu Ala Asp Ala
     130                 135                 140                
 Leu Lys His Lys Ser Gln Val Ile Asn Glu Met Gln Lys Lys Asp His
 145                 150                 155                 160
 Lys Gln Leu Trp Met Gly Leu Gln Asn Asp Arg Phe Asp Gln Phe Trp
                 165                 170                 175    
 Ala Ile Asn Arg Lys Leu Met Glu Tyr Pro Ala Glu Glu Asn Gly Phe
             180                 185                 190        
 Arg Tyr Ile Pro Phe Arg Ile Tyr Gln Thr Thr Thr Glu Arg Pro Phe
         195                 200                 205            
 Ile Gln Lys Leu Phe Arg Pro Val Ala Ala Asp Gly Gln Leu His Thr
     210                 215                 220                
 Leu Gly Asp Leu Leu Lys Glu Val Cys Pro Ser Ala Ile Asp Pro Glu
 225                 230                 235                 240
 Asp Gly Glu Lys Lys Asn Gln Val Met Ile His Gly Ile Glu Pro Met
                 245                 250                 255    
 Leu Glu Thr Pro Leu Gln Trp Leu Ser Glu His Leu Ser Tyr Pro Asp
             260                 265                 270        
 Asn Phe Leu His Ile Ser Ile Ile Pro Gln Pro Thr Asp
         275                 280                 285



      <210> 2902
      <211> 482
      <212> PRT
      <213> Homo sapiens


      <400> 2902
 Met Asp Arg Ile Leu Gly Leu Val Pro Val Thr Leu Trp Ile Arg Arg
   1               5                  10                  15    
 Ala Ile Trp Ala Cys Thr Ala Val Val Ala Phe Met Val Arg Arg Arg
              20                  25                  30        
 His Ala Val Arg Arg Arg Glu Glu Leu Ala Gln Arg Asp Ser Ala Gln
          35                  40                  45            
 Gly Glu Val His Gly Lys Ala Arg Ala Lys Met Gln Pro Ala Pro Gln
      50                  55                  60                
 Ala Gly Gly Gly Leu Thr Ser Pro Met Pro Glu Val Ser Pro Arg Leu
  65                  70                  75                  80
 Leu Gln Thr Leu Cys Ser Arg Val Gln Lys Glu Met Ser Arg Ser Ser
                  85                  90                  95    
 His Gln Gly Pro Asp Glu Leu Leu Lys Thr Ser Val Thr Lys Gln Pro
             100                 105                 110        
 Pro Glu His Pro Gly Met Thr Asp Ala Lys Tyr Thr Pro His Gly Ser
         115                 120                 125            
 Gln His Glu Asp His Gln Gly Gln Thr Val Asp Asp Leu Asn Asp Ser
     130                 135                 140                
 Thr Asp Arg Gln Gln Pro Ala Glu Leu Pro Gly Gln Glu Ile Thr Arg
 145                 150                 155                 160
 Arg Lys Gln Arg Leu Gln Ala Lys Glu Glu Lys Lys Glu Arg Pro Glu
                 165                 170                 175    
 Gln Ala Gly Ala Gly Val Glu Arg Ala Ala Asn Val Gly Val Lys Cys
             180                 185                 190        
 Arg Pro Ser Trp Pro Thr Pro Leu Arg Ala Cys Ala Arg Gly Gln Cys
         195                 200                 205            
 Lys Glu Leu Thr Ala Glu Val Gln Ser Leu Pro Ala Gly Leu Pro Ala
     210                 215                 220                
 Gly His Glu Gly Thr Ala Gly Glu Gly Ala Ser Lys Thr Ala Ala Glu
 225                 230                 235                 240
 Gly Ser Arg Cys Leu His Cys Thr Glu Asn Ser Arg Asp Gly Val Ser
                 245                 250                 255    
 Arg Glu Ser Thr Glu Glu Asn Ala Tyr Cys Leu Asp Leu Asp Gln Arg
             260                 265                 270        
 Leu Arg Lys Val His Glu Asn Thr Cys Asn His Tyr Lys Lys Met Thr
         275                 280                 285            
 Gln Asp Leu Ala Gln Glu Ser Lys Lys Asp Thr Ser Asn Phe Gln Arg
     290                 295                 300                
 Glu Ile Phe Phe Arg Glu Lys Met Ala Gln Glu Gly Arg Met Ala Ala
 305                 310                 315                 320
 Val Ser Thr Glu Thr Ala Leu Gln Pro Leu Arg Glu Glu Asn Asp His
                 325                 330                 335    
 Ser Arg Gln Lys Pro Ala Asp Phe Glu Ala Lys Phe Gln Leu Leu Arg
             340                 345                 350        
 Gly Gly Ala Leu Ala Pro Gly Val Leu Pro Ala Ala His Arg Gly Pro
         355                 360                 365            
 Glu Val Ser Gly Gly Pro Trp Asp Asp Arg Ala Pro Arg Arg Glu Ala
     370                 375                 380                
 Gly His Asn Gln Ser Glu Asp Val Gly Glu Ser Tyr Ser Gln Glu Tyr
 385                 390                 395                 400
 Leu Val Asp Ser Gln Phe Glu Glu Ser Pro Pro Trp Ala His Gly Leu
                 405                 410                 415    
 Gln Glu Ala Arg Gly Pro Gly Lys Ala Ile Ala Gly Val Pro Val Arg
             420                 425                 430        
 Ser Glu Glu Gly Val Thr Ala Ala Glu Ala Ala Asp Trp Gln Glu Val
         435                 440                 445            
 Pro Leu Lys Asp Ala Lys Glu Tyr Ala Glu Ser Ile Gly Ala Ile Val
     450                 455                 460                
 Val Glu Thr Ser Ala Lys Asn Ala Ile Asn Ile Glu Glu Leu Phe Gln
 465                 470                 475                 480
 Gly Ile
        



      <210> 2903
      <211> 276
      <212> PRT
      <213> Homo sapiens


      <400> 2903
 Met Pro Arg Ala Ala Leu Gln Asp Ala Pro Arg Ala Val His Gly Asp
   1               5                  10                  15    
 Lys Tyr Ala Gly Gln Glu Glu Ala Gln Lys Asn Asn Trp Ser Val Ser
              20                  25                  30        
 Ile Ala Val Ala Asp Asp Gly Gly His Leu Leu Ala Leu Ser Arg Met
          35                  40                  45            
 Asp Asp Cys Ala Pro Ile Ala Ala Tyr Ile Ser Gln Glu Lys Ala Arg
      50                  55                  60                
 Thr Ala Ala Leu Gly Arg Arg Glu Thr Lys Gly Tyr Asp Asn Asp Met
  65                  70                  75                  80
 Ile Gln Ser Met Leu Asp Arg Ile Glu Leu Thr Val Phe Val Asp Asn
                  85                  90                  95    
 Ala Pro Ala Ile Lys Val Tyr Lys Lys Tyr Gly Phe Glu Ile Glu Gly
             100                 105                 110        
 Thr Gly Lys Lys Tyr Ala Leu Arg Asn Gly Glu Tyr Val Asp Ala Tyr
         115                 120                 125            
 Tyr Met Ala Arg Val Asn Lys Ile Arg Leu His Gly His Val Ile Leu
     130                 135                 140                
 Ile Thr Asn Lys Pro Thr Leu Thr Gly Ser Leu Glu Lys Val Arg Glu
 145                 150                 155                 160
 Gln Val Gln Ala Ala His Ala Leu Gly Leu Thr Ala Val Ile Ser Ser
                 165                 170                 175    
 Ser Ile Glu Ser Ser Leu Gly Leu Thr Gln Leu Ala Arg Ile Ala Ala
             180                 185                 190        
 Trp Leu Thr Pro Asp Thr Ile Pro Gly Leu Asp Thr Leu Asp Leu Met
         195                 200                 205            
 Gln Ala Gln Gln Ala Met Cys Leu Leu Ile Cys Ala Glu Met Tyr Gln
     210                 215                 220                
 Val Ser Arg Leu Gln His Ile Cys Glu Leu Phe Ile Ile Thr Gln Leu
 225                 230                 235                 240
 Gln Ser Met Pro Ser Arg Glu Leu Ala Ser Met Asn Leu Asp Ile Val
                 245                 250                 255    
 Asp Leu Leu Lys Lys Ala Lys Val Phe Lys Thr Gly Asp Leu Ile Met
             260                 265                 270        
 Gly Met His Asp
         275    



      <210> 2904
      <211> 250
      <212> PRT
      <213> Homo sapiens


      <400> 2904
 Met Thr Thr Gly Pro Arg Ser Ser Ser Arg Pro Thr Arg His His Asn
   1               5                  10                  15    
 Asn Asn Ala Thr Ile Thr Phe Thr Phe His Asn Thr Asn Glu Val Asp
              20                  25                  30        
 Lys Asp Arg Leu Met Arg Lys Glu Arg Glu Val Leu Met Ala His Asn
          35                  40                  45            
 Leu Thr Pro Gly Gln Leu Gln Leu Phe His Ser Leu Met Leu Ala Pro
      50                  55                  60                
 Arg Ser Leu Ala Met Leu Glu Ser Glu Ser Leu Glu Gly Ser His Ser
  65                  70                  75                  80
 Arg Gln Lys Lys Thr Phe Phe Leu Gly Asp Gly Gln Lys Leu Lys Asp
                  85                  90                  95    
 Trp His Asp Lys Glu Ala Ile Arg Arg Asp Ala Gln Arg Val Ala Gly
             100                 105                 110        
 Ala Glu Val Tyr Val Cys Leu Leu Phe Leu Gln Thr Glu Phe Trp Gln
         115                 120                 125            
 Gln His Val Lys Asn Lys Ile Glu Gly Leu Phe Val Cys Ala Ser Cys
     130                 135                 140                
 Leu Cys Phe His Gln Lys Leu His Trp Gly Leu Arg Ser Gln Arg Thr
 145                 150                 155                 160
 Glu Ala Arg Gln Phe Gly Pro Asp Ser Leu Asp Leu Gln Met Gly Val
                 165                 170                 175    
 Ser Gln Leu Ala Leu Ser Gly Pro Ala Leu Cys Thr Ser Cys Gln Val
             180                 185                 190        
 Ser Val Asn Ser Gly Trp Leu Val Gly Trp Pro Thr Phe Pro Thr Pro
         195                 200                 205            
 Trp Glu Pro Cys Trp Ala Ala Trp Gln Leu Ser Val Glu Ala Pro Pro
     210                 215                 220                
 Glu His Arg Ala Asp Gly Thr Thr Glu Thr Gln Leu Leu Lys Cys Leu
 225                 230                 235                 240
 Gly Ser Ala Val Ser Gly Ala Asn Pro Ser
                 245                 250



      <210> 2905
      <211> 543
      <212> PRT
      <213> Homo sapiens

      <220>
      <221> misc_feature
      <222> (1)...(543)
      <223> Xaa = any amino acid or symbol as shown in the table 8 as set forth in Example 2


      <400> 2905
 Met Glu Ile Pro Ala Val Ile Leu Thr Val Ala Pro Ile Leu His Leu
   1               5                  10                  15    
 Thr Ser Cys Gly Phe Pro Val Thr Gly Asp Gly Leu Lys Gln Ala Glu
              20                  25                  30        
 Gly Lys Cys Ala Pro Glu Glu Trp Asn Pro Thr Lys Phe Ile Lys Leu
          35                  40                  45            
 Thr Asp Asn Gln Ala Cys Phe Ala Cys Gly Leu Trp Pro Leu Ser Glu
      50                  55                  60                
 Ile Gln Arg Arg Thr Ser Arg Thr Val Thr Ile Ile Ser Arg Ile Ser
  65                  70                  75                  80
 Ala Leu Arg Glu Lys Gly Asn Gly Arg Lys Pro Thr Ser Ile Ser Gly
                  85                  90                  95    
 Ser Val Asn Glu Met Arg Gln Val Leu Val Lys Asp Gln Val Ser Met
             100                 105                 110        
 Pro Arg Val Leu Pro Thr Ile Ile Phe Val Pro Asp Glu Ala Gly Phe
         115                 120                 125            
 Ser Ala Gly Ala Val Trp Pro Cys Ala Ala Pro Leu Trp Gly Ser Ser
     130                 135                 140                
 Trp Thr Pro Leu Lys Val Glu Asn Cys Ser Phe Tyr Ile Arg Leu Ser
 145                 150                 155                 160
 Phe Ala Ile Ser Val Gly Gly Asp Glu Leu Lys Ile Ala Lys Leu Val
                 165                 170                 175    
 Ser Ala Phe Pro Glu Arg Ala Tyr Asp Leu Val Gly His Gln His Gln
             180                 185                 190        
 Arg Pro Lys Val Asp Lys Thr Thr Lys Met Gly Arg Asn Gln Ser Arg
         195                 200                 205            
 Lys Ala Glu Asn Ser Lys Asn Gln Asn Met Ser Ser Pro Pro Lys Glu
     210                 215                 220                
 His Asn Ser Ser Pro Ala Arg Glu Gln Asn Trp Met Glu Asn Glu Phe
 225                 230                 235                 240
 Asp Glu Leu Arg Glu Val Gly Phe Arg Arg Ser Val Ile Thr Asn Phe
                 245                 250                 255    
 Ser Glu Leu Lys Glu His Val Leu Thr His His Lys Glu Ala Lys Asn
             260                 265                 270        
 Leu Glu Lys Arg Leu Asp Glu Trp Leu Thr Arg Ile Asn Ser Val Glu
         275                 280                 285            
 Lys Ser Leu Asn Asp Leu Met Glu Leu Lys Thr Thr Leu Arg Glu Leu
     290                 295                 300                
 Arg Glu Ala Tyr Ile Ser Phe Asn Ser Gln Phe Asp Gln Ala Glu Glu
 305                 310                 315                 320
 Arg Val Ser Val Ile Glu Asp Gln Ile Ser Glu Ile Lys Gln Glu Val
                 325                 330                 335    
 Lys Phe Arg Glu Lys Arg Val Lys Arg Asn Glu Gln Ser Leu Gln Glu
             340                 345                 350        
 Ile Trp Asp Tyr Val Lys Arg Pro Asn Leu Arg Leu Ile Gly Ile Pro
         355                 360                 365            
 Glu Ser Asp Glu Glu Asn Gly Thr Lys Leu Glu Asn Thr Leu Gln Asp
     370                 375                 380                
 Ile Ile Gln Glu Asn Phe Pro Asn Ile Ala Arg Gln Ala Asn Ile Gln
 385                 390                 395                 400
 Ile Gln Gly Lys Leu Gln Arg Thr Pro Thr Lys Val Ala Ser Ser Arg
                 405                 410                 415    
 Thr Ala Thr Pro Arg His Ile Ile Ser Val Gly Ser Pro Lys Leu Asn
             420                 425                 430        
 Met Lys Glu Lys Ile Leu Arg Ala Ala Gln Arg Glu Arg Ser Gly Leu
         435                 440                 445            
 Pro Thr Lys Gly Lys Pro Phe Arg Leu Thr Ala Ala Asp Leu Ser Ala
     450                 455                 460                
 Glu Thr Ser Thr Ser Gln Lys Thr Glu Trp Gly Pro Ile Phe Asn Ile
 465                 470                 475                 480
 Leu Lys Glu Lys Asn Phe Gln Pro Arg Ile Ser Tyr Pro Ala Lys Leu
                 485                 490                 495    
 Ser Phe Ile Ser Glu Gly Glu Ile Lys Tyr Phe Thr Asp Gln Ala Lys
             500                 505                 510        
 Cys Leu Arg Asp Phe Val Thr Thr Arg Ala Phe Ser Cys Leu Pro Xaa
         515                 520                 525            
 Lys Ser Thr Arg Pro Ala Leu Lys Glu Leu Leu Lys Gly Ser Thr
     530                 535                 540            



      <210> 2906
      <211> 53
      <212> PRT
      <213> Homo sapiens

      <220>
      <221> misc_feature
      <222> (1)...(53)
      <223> Xaa = any amino acid or symbol as shown in the table 8 as set forth in Example 2


      <400> 2906
 Gly Glu Lys Pro Val Pro Thr Trp Leu Gln Asp Glu Ala Gly Gln Trp
   1               5                  10                  15    
 Leu Leu Gly Phe Val Ala Gln Pro Trp Gly Trp Pro Gly Ser Glu Arg
              20                  25                  30        
 His Glu Pro Xaa His Gly Gly Val Leu Phe Arg Leu Gly Pro Ser Ala
          35                  40                  45            
 Pro Pro Gly Lys Leu
      50            



      <210> 2907
      <211> 145
      <212> PRT
      <213> Homo sapiens

      <220>
      <221> misc_feature
      <222> (1)...(145)
      <223> Xaa = any amino acid or symbol as shown in the table 8 as set forth in Example 2


      <400> 2907
 Pro Gly Gly Gln Thr Pro Glu Gly Pro Ser Gly Gly Gly Val Ser His
   1               5                  10                  15    
 Leu Gly Glu Gly Asp Pro His Pro Ala Ala Leu Pro Gly Arg Gly Val
              20                  25                  30        
 Phe Glu Ala Leu Pro Pro Leu Xaa Gly Ser Pro Gly Ala His Pro Gly
          35                  40                  45            
 Arg Ala Lys Gly Thr Glu Glu Gly His Gly Ala Gly Ala Ala Gly Ile
      50                  55                  60                
 Cys Gly Ala Phe Leu Cys Leu Ser Gln Pro Gln Ala Ala Ala Leu Gly
  65                  70                  75                  80
 Val Leu His Thr Gly Pro Gln Thr Pro Ala Ser Pro Leu Arg Gly Cys
                  85                  90                  95    
 Thr Ser Pro Val Leu Pro Ala Cys Thr Ser Ser Gly Ala Leu Pro Ser
             100                 105                 110        
 Thr Ser Arg Pro Val Gly Tyr Pro Pro Leu Gly Thr Ala Ala Ser Val
         115                 120                 125            
 Gln Pro Gln Gly Arg Ala Ser Phe His Thr His Val Gln Cys Ser Thr
     130                 135                 140                
 Pro
 145



      <210> 2908
      <211> 151
      <212> PRT
      <213> Homo sapiens

      <220>
      <221> misc_feature
      <222> (1)...(151)
      <223> Xaa = any amino acid or symbol as shown in the table 8 as set forth in Example 2


      <400> 2908
 Tyr Lys Asn Thr Ile Thr Asp Tyr Tyr Glu His Leu Tyr Ala His Lys
   1               5                  10                  15    
 Leu Glu Asn Leu Glu Glu Met Asn Lys Arg Arg Ala Ser Thr Ile Cys
              20                  25                  30        
 Thr Glu Thr Ile Pro Lys Lys Leu Arg Arg Arg Asp Ser Ser Leu Thr
          35                  40                  45            
 His Ser Met Arg Ala Arg Arg Leu Ser Val Asp Val Lys Pro Gln Asp
      50                  55                  60                
 Arg Ser Arg Gly Pro Ser Glu Cys Thr Ile Phe Arg Ala Gly Val Pro
  65                  70                  75                  80
 Glu Gly Thr Arg Gly Ala Leu Trp Leu Pro His Phe Gln Thr Glu Ser
                  85                  90                  95    
 Asp Pro Gly Ser Lys Pro Ala Ile Thr Leu Leu Val Ile His Pro Asp
             100                 105                 110        
 Glu Leu Gln Ile Tyr Val Arg Thr Lys Thr Cys Thr Arg Met Phe Ile
         115                 120                 125            
 Ala Ala Leu Phe Ile Ile Ala Lys Thr Xaa Lys Gln Pro Arg Tyr Pro
     130                 135                 140                
 Ser Cys Leu Ile Thr Ser Thr
 145                 150    



      <210> 2909
      <211> 605
      <212> PRT
      <213> Homo sapiens


      <400> 2909
 Lys His Arg Gln Glu Asn Asn Ala Leu Asp Met Ala Pro Glu Ile His
   1               5                  10                  15    
 Met Thr Gly Pro Met Cys Leu Ile Glu Asn Thr Asn Gly Glu Leu Val
              20                  25                  30        
 Ala Asn Pro Glu Ala Leu Lys Ile Leu Ser Ala Ile Thr Gln Pro Val
          35                  40                  45            
 Val Val Val Ala Ile Val Gly Leu Tyr Arg Thr Gly Lys Ser Tyr Leu
      50                  55                  60                
 Met Asn Lys Leu Ala Gly Lys Asn Lys Gly Phe Ser Leu Gly Ser Thr
  65                  70                  75                  80
 Val Lys Ser His Thr Lys Gly Ile Trp Met Trp Cys Val Pro His Pro
                  85                  90                  95    
 Lys Lys Pro Glu His Thr Leu Val Leu Leu Asp Thr Glu Gly Leu Gly
             100                 105                 110        
 Asp Val Lys Lys Gly Asp Asn Gln Asn Asp Ser Trp Ile Phe Thr Leu
         115                 120                 125            
 Ala Val Leu Leu Ser Ser Thr Leu Val Tyr Asn Ser Met Gly Thr Ile
     130                 135                 140                
 Asn Gln Gln Ala Met Asp Gln Leu Tyr Tyr Val Thr Glu Leu Thr His
 145                 150                 155                 160
 Arg Ile Arg Ser Lys Ser Ser Pro Asp Glu Asn Glu Asn Glu Asp Ser
                 165                 170                 175    
 Ala Asp Phe Val Ser Phe Phe Pro Asp Phe Val Trp Thr Leu Arg Asp
             180                 185                 190        
 Phe Ser Leu Asp Leu Glu Ala Asp Gly Gln Pro Leu Thr Pro Asp Glu
         195                 200                 205            
 Tyr Leu Glu Tyr Ser Leu Lys Leu Thr Gln Gly Thr Ser Gln Lys Asp
     210                 215                 220                
 Lys Asn Phe Asn Leu Pro Arg Leu Cys Ile Arg Lys Phe Phe Pro Lys
 225                 230                 235                 240
 Lys Lys Cys Phe Val Phe Asp Leu Pro Ile His Arg Arg Lys Leu Ala
                 245                 250                 255    
 Gln Leu Glu Lys Leu Gln Asp Glu Glu Leu Asp Pro Glu Phe Val Gln
             260                 265                 270        
 Gln Val Ala Asp Phe Cys Ser Tyr Ile Phe Ser Asn Ser Lys Thr Lys
         275                 280                 285            
 Thr Leu Ser Gly Gly Ile Lys Val Asn Gly Pro Arg Leu Glu Ser Leu
     290                 295                 300                
 Val Leu Thr Tyr Ile Asn Ala Ile Ser Arg Gly Asp Leu Pro Cys Met
 305                 310                 315                 320
 Glu Asn Ala Val Leu Ala Leu Ala Gln Ile Glu Asn Ser Ala Ala Val
                 325                 330                 335    
 Gln Lys Ala Ile Ala His Tyr Asp Gln Gln Met Gly Gln Lys Val Gln
             340                 345                 350        
 Leu Pro Ala Glu Thr Leu Gln Glu Leu Leu Asp Leu His Arg Val Ser
         355                 360                 365            
 Glu Arg Glu Ala Thr Glu Val Tyr Met Lys Asn Ser Phe Lys Asp Val
     370                 375                 380                
 Asp His Leu Phe Gln Lys Lys Leu Ala Ala Gln Leu Asp Lys Lys Arg
 385                 390                 395                 400
 Asp Asp Phe Cys Lys Gln Asn Gln Glu Ala Ser Ser Asp Arg Cys Ser
                 405                 410                 415    
 Ala Leu Leu Gln Val Ile Phe Ser Pro Leu Glu Glu Glu Val Lys Ala
             420                 425                 430        
 Gly Ile Tyr Ser Lys Pro Gly Gly Tyr Cys Leu Phe Ile Gln Lys Leu
         435                 440                 445            
 Gln Asp Leu Glu Lys Lys Tyr Tyr Glu Glu Pro Arg Lys Gly Ile Gln
     450                 455                 460                
 Ala Glu Glu Ile Leu Gln Thr Tyr Leu Lys Ser Lys Glu Ser Val Thr
 465                 470                 475                 480
 Asp Ala Ile Leu Gln Thr Asp Gln Ile Leu Thr Glu Lys Glu Lys Glu
                 485                 490                 495    
 Ile Glu Val Glu Cys Val Lys Ala Glu Ser Ala Gln Ala Ser Ala Lys
             500                 505                 510        
 Met Val Glu Glu Met Gln Ile Lys Tyr Gln Gln Met Met Glu Glu Lys
         515                 520                 525            
 Glu Lys Ser Tyr Gln Glu His Val Lys Gln Leu Thr Glu Lys Met Glu
     530                 535                 540                
 Arg Glu Arg Ala Gln Leu Leu Glu Glu Gln Glu Lys Thr Leu Thr Ser
 545                 550                 555                 560
 Lys Leu Gln Glu Gln Ala Arg Val Leu Lys Glu Arg Cys Gln Gly Glu
                 565                 570                 575    
 Ser Thr Gln Leu Gln Asn Glu Ile Gln Lys Leu Gln Lys Thr Leu Lys
             580                 585                 590        
 Lys Lys Thr Lys Arg Tyr Met Ser His Lys Leu Lys Ile
         595                 600                 605



      <210> 2910
      <211> 340
      <212> PRT
      <213> Homo sapiens


      <400> 2910
 Phe Leu Ala Ser Leu Gln Trp Val Gln Thr Ser Ser Phe Ser Ser Glu
   1               5                  10                  15    
 Lys Phe Val Ile Thr Asp Leu Leu Lys Pro Thr Ser Val Asn Leu Ser
              20                  25                  30        
 Lys Ser Phe Ser Val Gln Leu Cys Ser Ile Ala Gly Gly Ser Leu Arg
          35                  40                  45            
 Pro Thr Pro Glu Ile Gln Glu Val Lys Thr Pro Glu Glu Leu Glu Thr
      50                  55                  60                
 Phe Met Leu Lys His Gly Glu Asn Ile Ile Asp Thr Leu Gly Ala Glu
  65                  70                  75                  80
 Val Asp Arg Leu Glu Lys Glu Leu Lys Ser Gly Ser Leu Val Pro Cys
                  85                  90                  95    
 Ile Pro Ala Ala Pro Ala Val Thr Lys Arg Gly Gln Gly Thr Ala Pro
             100                 105                 110        
 Ala Ile Ala Ser Val Gly Gly Ser Pro Lys Pro Trp Gln Leu Pro Arg
         115                 120                 125            
 Gly Val Gly Pro Val Gly Ala Gln Lys Ser Arg Thr Glu Val Trp Lys
     130                 135                 140                
 Ser Leu Pro Arg Phe Gln Arg Met Tyr Gly Lys His Leu Asp Ala Gln
 145                 150                 155                 160
 Asn Asp Arg Ser Thr Asp Ser Leu His Ser Ala Pro Gly Lys Ala Thr
                 165                 170                 175    
 Asp Thr Gln Cys Gln Pro Leu Lys Ala Ala Lys Ser Gly Leu Tyr Pro
             180                 185                 190        
 Ala Glu Leu Lys Arg Trp Ser Cys Pro Trp Leu Trp Glu Pro Thr Phe
         195                 200                 205            
 Cys Ile Ser Val Thr Trp Ser Asp Leu Glu Gln Leu Arg Lys Ile Arg
     210                 215                 220                
 Arg Arg Ser Pro His Glu Asp Thr Glu Ser Phe Thr Val Tyr Leu Arg
 225                 230                 235                 240
 Ser Asp Val Glu Ala Lys Ser Leu Glu Val Trp Gly Ser Pro Glu Ala
                 245                 250                 255    
 Leu Ala Arg Glu Lys Lys Leu Arg Lys Glu Ala Glu Ile Glu Tyr Arg
             260                 265                 270        
 Glu Lys Gly Ser Ile Asn Ser Ala Thr Leu Ile Glu Phe Ser Arg Tyr
         275                 280                 285            
 Leu Ser Asp Thr Arg Tyr Arg Thr Arg Ser Cys Ala Trp Cys Leu Lys
     290                 295                 300                
 Cys Ile Cys Lys Ile Ile Pro Thr Met Ala Asn Ser Cys Ser Pro Asn
 305                 310                 315                 320
 Thr Cys Ser Leu Cys Leu Leu Tyr Ser Ser Pro Ala Leu Pro Trp Thr
                 325                 330                 335    
 Leu Lys Phe Ala
             340



      <210> 2911
      <211> 192
      <212> PRT
      <213> Homo sapiens


      <400> 2911
 Ala Gly Ile Leu Arg Pro Glu Ile Glu Pro Asp Cys Ser Ser Pro Lys
   1               5                  10                  15    
 Ser Trp Arg Ala Ser Ser Asn Cys Ser Arg Ala Glu Pro Ile Lys Glu
              20                  25                  30        
 Phe Ser Arg Lys Val Gly Arg Pro Pro Thr Pro Ser Pro Gln Gly Ile
          35                  40                  45            
 Gln Gly His Ser Arg Pro Gly Pro Ala Pro Pro Ala Arg Gly Pro Trp
      50                  55                  60                
 Arg Val Leu Arg Arg Pro Pro Gln Pro Thr Ala Pro Arg Ala Ser Asp
  65                  70                  75                  80
 Ala Trp His Arg Ser Gly Pro Gln Arg Val Ala Leu Thr Arg Arg Gly
                  85                  90                  95    
 Ser Cys Gly Ser Gln Cys Ala Pro Arg Gly Lys Arg Gln Pro Leu Arg
             100                 105                 110        
 Pro Ala Pro Arg Ala Ala Arg Gly Ser Ala Arg Pro Leu Gly Phe Cys
         115                 120                 125            
 Pro Ala Cys Pro Arg Ile Arg Arg Gly Ser Pro Gly Val His Arg Ser
     130                 135                 140                
 Ala Ser Ala Ser Val Trp Arg Ser Ala Ala Gly Cys Gly Arg Arg Ala
 145                 150                 155                 160
 Ser Gln Gly Pro Ala Arg Arg Gly Glu Arg Gly Thr His Asp Ala Ser
                 165                 170                 175    
 Pro Thr Pro Ala Pro Gly Pro Arg Leu Ala Pro Ala Cys Gly Leu Arg
             180                 185                 190        





      <210> 2912
      <211> 380
      <212> PRT
      <213> Homo sapiens


      <400> 2912
 Met Thr Gly Phe Pro Phe Gln Ala Glu Thr Thr Val Tyr Val Ile Val
   1               5                  10                  15    
 Arg Cys Lys Leu Asp Asp Arg Val Ala Thr Glu Ala Glu Phe Ser Pro
              20                  25                  30        
 Glu Asp Ser Pro Ser Val Arg Met Glu Ala Lys Val Glu Asn Glu Tyr
          35                  40                  45            
 Thr Ile Ser Val Lys Ala Pro Asn Leu Ser Ser Gly Asn Val Ser Leu
      50                  55                  60                
 Lys Ile Tyr Ser Gly Asp Leu Val Val Cys Glu Thr Val Ile Ser Tyr
  65                  70                  75                  80
 Tyr Thr Asp Met Glu Glu Ile Gly Asn Leu Leu Ser Asn Ala Ala Asn
                  85                  90                  95    
 Pro Val Glu Phe Met Cys Gln Ala Phe Lys Ile Val Pro Tyr Asn Thr
             100                 105                 110        
 Glu Thr Leu Asp Lys Leu Leu Thr Glu Ser Leu Lys Asn Asn Ile Pro
         115                 120                 125            
 Ala Ser Gly Leu His Leu Phe Gly Ile Asn Gln Leu Glu Glu Glu Asp
     130                 135                 140                
 Met Met Thr Asn Gln Arg Asp Glu Glu Leu Pro Thr Leu Leu His Phe
 145                 150                 155                 160
 Ala Ala Lys Tyr Gly Leu Lys Asn Leu Thr Ala Leu Leu Leu Thr Cys
                 165                 170                 175    
 Pro Gly Ala Leu Gln Ala Tyr Ser Val Ala Asn Lys His Gly His Tyr
             180                 185                 190        
 Pro Asn Thr Ile Ala Glu Lys His Gly Phe Arg Asp Leu Arg Gln Phe
         195                 200                 205            
 Ile Asp Glu Tyr Val Glu Thr Val Asp Met Leu Lys Ser His Ile Lys
     210                 215                 220                
 Glu Glu Leu Met His Gly Glu Glu Ala Asp Ala Val Tyr Glu Ser Met
 225                 230                 235                 240
 Ala His Leu Ser Thr Asp Leu Leu Met Lys Cys Ser Leu Asn Pro Gly
                 245                 250                 255    
 Cys Asp Glu Asp Leu Tyr Glu Ser Met Ala Ala Phe Val Pro Ala Ala
             260                 265                 270        
 Thr Glu Asp Leu Tyr Val Glu Met Leu Gln Ala Ser Thr Ser Asn Pro
         275                 280                 285            
 Ile Pro Gly Asp Gly Phe Ser Arg Ala Thr Lys Asp Ser Met Ile Arg
     290                 295                 300                
 Lys Phe Leu Glu Gly Asn Ser Met Gly Met Thr Asn Leu Glu Arg Asp
 305                 310                 315                 320
 Gln Cys His Leu Gly Gln Glu Glu Asp Val Tyr His Thr Val Asp Asp
                 325                 330                 335    
 Asp Glu Ala Phe Ser Val Asp Leu Ala Ser Arg Pro Pro Val Pro Val
             340                 345                 350        
 Pro Arg Pro Glu Thr Thr Ala Pro Gly Ala His Gln Leu Pro Asp Asn
         355                 360                 365            
 Glu Pro Tyr Ile Phe Lys Gly Lys Tyr Gly Arg Glu
     370                 375                 380



      <210> 2913
      <211> 488
      <212> PRT
      <213> Homo sapiens


      <400> 2913
 Ala Glu Ala Gly Pro Gly Ala Arg Ala Ala Ala Ala Met Ala Ile Lys
   1               5                  10                  15    
 Phe Leu Glu Val Ile Lys Pro Phe Cys Val Ile Leu Pro Glu Ile Gln
              20                  25                  30        
 Lys Pro Glu Arg Lys Ile Gln Phe Lys Glu Lys Val Leu Trp Thr Ala
          35                  40                  45            
 Ile Thr Leu Phe Ile Phe Leu Val Cys Cys Gln Ile Pro Leu Phe Gly
      50                  55                  60                
 Ile Met Ser Ser Asp Ser Ala Asp Pro Phe Tyr Trp Met Arg Val Ile
  65                  70                  75                  80
 Leu Ala Ser Asn Arg Gly Thr Leu Met Glu Leu Gly Ile Ser Pro Ile
                  85                  90                  95    
 Val Thr Ser Gly Leu Ile Met Gln Leu Leu Ala Gly Ala Lys Ile Ile
             100                 105                 110        
 Glu Val Gly Asp Thr Pro Lys Asp Arg Ala Leu Phe Asn Gly Ala Gln
         115                 120                 125            
 Lys Leu Phe Gly Met Ile Ile Thr Ile Gly Gln Ser Ile Val Tyr Val
     130                 135                 140                
 Met Thr Gly Met Tyr Gly Asp Pro Ser Glu Met Gly Ala Gly Ile Cys
 145                 150                 155                 160
 Leu Leu Ile Thr Ile Gln Leu Phe Val Ala Gly Leu Ile Val Leu Leu
                 165                 170                 175    
 Leu Asp Glu Leu Leu Gln Lys Gly Tyr Gly Leu Gly Ser Gly Ile Ser
             180                 185                 190        
 Leu Phe Ile Ala Thr Asn Ile Cys Glu Thr Ile Val Trp Lys Ala Phe
         195                 200                 205            
 Ser Pro Thr Thr Val Asn Thr Gly Arg Gly Met Glu Phe Glu Gly Ala
     210                 215                 220                
 Ile Ile Ala Leu Phe His Leu Leu Ala Thr Arg Thr Asp Lys Val Arg
 225                 230                 235                 240
 Ala Leu Arg Glu Ala Phe Tyr Arg Gln Asn Leu Pro Asn Leu Met Asn
                 245                 250                 255    
 Leu Ile Ala Thr Ile Phe Val Phe Ala Val Val Ile Tyr Phe Gln Gly
             260                 265                 270        
 Phe Arg Val Asp Leu Pro Ile Lys Ser Ala Arg Tyr Arg Gly Gln Tyr
         275                 280                 285            
 Asn Thr Tyr Pro Ile Lys Leu Phe Tyr Thr Ser Asn Ile Pro Ile Ile
     290                 295                 300                
 Leu Gln Ser Ala Leu Val Ser Asn Leu Tyr Val Ile Ser Gln Met Leu
 305                 310                 315                 320
 Ser Ala Arg Phe Ser Gly Asn Leu Leu Val Ser Leu Leu Gly Thr Trp
                 325                 330                 335    
 Ser Asp Thr Ser Ser Gly Gly Pro Ala Arg Ala Tyr Pro Val Gly Gly
             340                 345                 350        
 Leu Cys Tyr Tyr Leu Ser Pro Pro Glu Ser Phe Gly Ser Val Leu Glu
         355                 360                 365            
 Asp Pro Val His Ala Val Val Tyr Ile Val Phe Met Leu Gly Ser Cys
     370                 375                 380                
 Ala Phe Phe Ser Lys Thr Trp Ile Glu Val Ser Gly Ser Ser Ala Lys
 385                 390                 395                 400
 Asp Val Ala Lys Gln Leu Lys Glu Gln Gln Met Val Met Arg Gly His
                 405                 410                 415    
 Arg Glu Thr Ser Met Val His Glu Leu Asn Arg Tyr Ile Pro Thr Ala
             420                 425                 430        
 Ala Ala Phe Gly Gly Leu Cys Ile Gly Ala Leu Ser Val Leu Ala Asp
         435                 440                 445            
 Phe Leu Gly Ala Ile Gly Ser Gly Thr Gly Ile Leu Leu Ala Val Thr
     450                 455                 460                
 Ile Ile Tyr Gln Tyr Phe Glu Ile Phe Val Lys Glu Gln Ser Glu Val
 465                 470                 475                 480
 Gly Ser Met Gly Ala Leu Leu Phe
                 485            



      <210> 2914
      <211> 321
      <212> PRT
      <213> Homo sapiens


      <400> 2914
 Ile His Ile Pro Ile Thr Leu Tyr Pro Ser Ile Leu Thr Phe Pro Trp
   1               5                  10                  15    
 Gln Pro Lys Thr Gly Ala Tyr Gln Tyr Thr Ile Arg Ala His Gly Gly
              20                  25                  30        
 Ser Gly Asn Phe Ser Trp Ser Ser Ser Ser His Leu Val Ala Thr Val
          35                  40                  45            
 Thr Val Lys Gly Val Met Thr Thr Gly Ser Asp Ile Gly Phe Ser Val
      50                  55                  60                
 Ile Gln Ala His Asp Val Gln Asn Pro Leu His Phe Gly Glu Met Lys
  65                  70                  75                  80
 Val Tyr Val Ile Glu Pro His Ser Met Glu Phe Ala Pro Cys Gln Val
                  85                  90                  95    
 Glu Ala Arg Val Gly Gln Ala Leu Glu Leu Pro Leu Arg Ile Ser Gly
             100                 105                 110        
 Leu Met Pro Gly Gly Ala Ser Glu Val Val Thr Leu Ser Asp Cys Ser
         115                 120                 125            
 His Phe Asp Leu Ala Val Glu Val Glu Asn Gln Gly Val Phe Gln Pro
     130                 135                 140                
 Leu Pro Gly Arg Leu Pro Pro Gly Ser Glu His Cys Ser Gly Ile Arg
 145                 150                 155                 160
 Val Lys Ala Glu Ala Gln Gly Ser Thr Thr Leu Leu Val Ser Tyr Arg
                 165                 170                 175    
 His Gly His Val His Leu Ser Ala Lys Ile Thr Ile Ala Ala Tyr Leu
             180                 185                 190        
 Pro Leu Lys Ala Val Asp Pro Ser Ser Val Ala Leu Val Thr Leu Gly
         195                 200                 205            
 Ser Ser Lys Glu Met Leu Phe Glu Gly Gly Pro Arg Pro Trp Ile Leu
     210                 215                 220                
 Glu Pro Ser Lys Phe Phe Gln Asn Val Thr Ala Glu Asp Thr Asp Ser
 225                 230                 235                 240
 Ile Gly Leu Ala Leu Phe Ala Pro His Ser Ser Arg Asn Tyr Gln Gln
                 245                 250                 255    
 His Trp Ile Leu Val Thr Cys Gln Ala Leu Gly Glu Gln Val Ile Ala
             260                 265                 270        
 Leu Ser Val Gly Asn Lys Pro Ser Leu Thr Asn Pro Phe Pro Ala Val
         275                 280                 285            
 Glu Pro Ala Val Val Lys Phe Val Cys Ala Pro Pro Ser Arg Leu Thr
     290                 295                 300                
 Leu Ala Pro Val Tyr Thr Ser Pro Gln Leu Asp Met Ser Cys Pro Leu
 305                 310                 315                 320
 Leu
    



      <210> 2915
      <211> 143
      <212> PRT
      <213> Homo sapiens


      <400> 2915
 Trp Lys Gln His Ser His His Gln Thr Trp Tyr Leu Leu Thr Ser Glu
   1               5                  10                  15    
 Ala Cys Lys Asp Ala Gly Leu Val Lys Ser Leu Gly Val Ser Ser Phe
              20                  25                  30        
 Asn Ser Arg Gln Leu Glu Leu Ile Gln Asn Asn Pro Gly Leu Lys Pro
          35                  40                  45            
 Lys Pro Val Ser Asn Glu Val Glu Cys His Pro Tyr Tyr Thr Gln Pro
      50                  55                  60                
 Lys Leu Leu Lys Phe Arg Gln Gln His Asp Ile Val Met Ile Ala Tyr
  65                  70                  75                  80
 Ser Pro Leu Gly Thr Thr Arg Asn Pro Thr Trp Thr Asn Met Ser Ser
                  85                  90                  95    
 Leu Pro Ser Leu Lys Asp Ala Leu Leu Lys Arg Cys Asn Lys Ile Thr
             100                 105                 110        
 Ala Gln Val Ile Leu Arg Phe Asn Ile Gln Gln Gly Val Val Val Ile
         115                 120                 125            
 Pro Lys Ser Phe Asn Pro Glu Lys Ile Lys Glu Asn Leu Gln Ala
     130                 135                 140            



      <210> 2916
      <211> 121
      <212> PRT
      <213> Homo sapiens

      <220>
      <221> misc_feature
      <222> (1)...(121)
      <223> Xaa = any amino acid or symbol as shown in the table 8 as set forth in Example 2


      <400> 2916
 Ile Leu Asp Thr Ser Pro Met Arg Trp Thr Gln Lys Asn Phe Ser Met
   1               5                  10                  15    
 Ile Leu Ala Gln Pro Glu Gln Gln Cys Lys Thr Leu Ser Gln Asn Lys
              20                  25                  30        
 Asn Lys Asp Arg Arg Ile Lys Lys Lys Glu Glu Lys Lys Lys Lys Lys
          35                  40                  45            
 Lys Lys Lys Lys Lys Lys Lys Lys Lys Lys Lys Lys Lys Lys Lys Lys
      50                  55                  60                
 Lys Lys Lys Lys Xaa Glu Lys Glu Lys Glu Lys Glu Lys Glu Lys Lys
  65                  70                  75                  80
 Lys Glu Lys Glu Glu Glu Lys Lys Lys Gln Glu Glu Glu Glu Glu Glu
                  85                  90                  95    
 Glu Glu Glu Glu Glu Glu Glu Glu Glu Glu Glu Glu Glu Glu Glu Glu
             100                 105                 110        
 Glu Glu Glu Glu Glu Arg Arg Arg Arg
         115                 120    



      <210> 2917
      <211> 86
      <212> PRT
      <213> Homo sapiens

      <220>
      <221> misc_feature
      <222> (1)...(86)
      <223> Xaa = any amino acid or symbol as shown in the table 8 as set forth in Example 2


      <400> 2917
 Xaa Val Xaa Tyr Lys Gln Ala Pro Glu Arg Met Leu Thr Glu Lys Gly
   1               5                  10                  15    
 Pro Xaa Leu Trp Xaa Glu Val Ala Leu Arg Val Lys Glu Ala Gly Xaa
              20                  25                  30        
 Ile Xaa Ile Leu His Val Gly His Ile Leu Gly Ser Asp Gly Ile Met
          35                  40                  45            
 His Thr Leu Gln Val Ser Arg Xaa Arg Asp Lys Thr Arg Val Cys Thr
      50                  55                  60                
 Glu Xaa Ala Cys Xaa His Thr Ala Xaa Ile Cys Thr Ala Cys Phe Ile
  65                  70                  75                  80
 Leu Asn Ser Leu Trp Ser
                  85    



      <210> 2918
      <211> 217
      <212> PRT
      <213> Homo sapiens


      <400> 2918
 Leu Ser Glu Arg Leu Val Arg Phe Arg Ala Arg Gly Phe Pro Arg Arg
   1               5                  10                  15    
 Gln Ala Asp Phe Ser Ser Leu Val Phe Leu Phe Ala Phe Phe Leu Pro
              20                  25                  30        
 Pro Pro Leu Pro Pro Ser Pro Ser Trp Pro Ser Ala Leu Arg Pro Leu
          35                  40                  45            
 Gln Gly His Leu Tyr Thr Val Pro Ile Arg Glu Gln Gly Asn Ile Tyr
      50                  55                  60                
 Lys Pro Asn Asn Lys Ala Met Ala Asp Glu Leu Ser Glu Lys Gln Val
  65                  70                  75                  80
 Tyr Asp Ala His Thr Lys Glu Ile Asp Leu Val Asn Arg Asp Pro Lys
                  85                  90                  95    
 His Leu Asn Asp Asp Val Val Lys Ile Asp Phe Glu Asp Val Ile Ala
             100                 105                 110        
 Glu Pro Glu Gly Thr His Ser Phe Asp Gly Ile Trp Lys Ala Ser Phe
         115                 120                 125            
 Thr Thr Phe Thr Val Thr Lys Tyr Trp Phe Tyr Arg Leu Leu Ser Ala
     130                 135                 140                
 Leu Phe Gly Ile Pro Met Ala Leu Ile Trp Gly Ile Tyr Phe Ala Ile
 145                 150                 155                 160
 Leu Ser Phe Leu His Ile Trp Ala Val Val Pro Cys Ile Lys Ser Phe
                 165                 170                 175    
 Leu Ile Glu Ile Gln Cys Ile Ser Arg Val Tyr Ser Ile Tyr Val His
             180                 185                 190        
 Thr Val Cys Asp Pro Leu Phe Glu Ala Val Gly Lys Ile Phe Ser Asn
         195                 200                 205            
 Val Arg Ile Asn Leu Gln Lys Glu Ile
     210                 215        



      <210> 2919
      <211> 375
      <212> PRT
      <213> Homo sapiens

      <220>
      <221> misc_feature
      <222> (1)...(375)
      <223> Xaa = any amino acid or symbol as shown in the table 8 as set forth in Example 2


      <400> 2919
 Gly Asp Phe Leu Ile Leu Tyr Phe Ser Val Asp Tyr Leu Phe Gly Pro
   1               5                  10                  15    
 Arg Arg Thr Trp Pro Gln Glu Ser Asn Gln Gly Cys Gly Arg Arg Leu
              20                  25                  30        
 Val Gln Asn Ala Leu Leu Tyr Arg Arg Gly Ser Pro Ala Leu Phe Ser
          35                  40                  45            
 Asn Phe Phe Phe Trp Pro Ser Ser Pro Ser Leu Pro Leu Pro Pro Ser
      50                  55                  60                
 Leu Ser Leu Ser Leu His Tyr Pro Pro Phe Phe Ser Pro Leu Gly Ser
  65                  70                  75                  80
 Ser Pro Pro Ser Arg Pro Gln Arg Leu Val Leu Ile Arg Ala Gly Arg
                  85                  90                  95    
 Gly Gly Trp Val Gly Ser Val Gly Glu Thr Met Thr Ser Ser Tyr Gly
             100                 105                 110        
 His Val Leu Glu Arg Gln Pro Ala Leu Gly Gly Arg Leu Asp Ser Pro
         115                 120                 125            
 Val Asn Leu Asp Thr Leu Gln Ala Lys Lys Asn Phe Ser Val Ser His
     130                 135                 140                
 Leu Leu Asp Leu Glu Glu Ala Gly Asp Met Val Ala Ala Gln Ala Asp
 145                 150                 155                 160
 Glu Asn Val Gly Glu Ala Gly Arg Ser Leu Leu Glu Ser Pro Gly Leu
                 165                 170                 175    
 Thr Ser Gly Ser Asp Thr Pro Gln Gln Asp Asn Asp Gln Leu Asn Ser
             180                 185                 190        
 Glu Glu Lys Lys Lys Arg Lys Gln Arg Arg Asn Arg Thr Thr Phe Asn
         195                 200                 205            
 Ser Ser Gln Leu Gln Ala Leu Glu Arg Val Phe Glu Arg Thr His Tyr
     210                 215                 220                
 Pro Asp Ala Phe Val Arg Glu Asp Leu Ala Arg Arg Val Asn Leu Thr
 225                 230                 235                 240
 Glu Ala Arg Val Gln Val Trp Phe Gln Asn Arg Arg Ala Lys Phe Arg
                 245                 250                 255    
 Arg Asn Glu Arg Ala Met Leu Ala Asn Lys Asn Ala Ser Leu Leu Lys
             260                 265                 270        
 Ser Tyr Ser Gly Asp Val Thr Ala Val Glu Gln Pro Ile Val Pro Arg
         275                 280                 285            
 Pro Ala Pro Arg Pro Thr Asp Tyr Leu Ser Trp Gly Thr Ala Ser Pro
     290                 295                 300                
 Tyr Arg Ser Ser Ser Leu Pro Arg Cys Cys Leu His Glu Gly Leu His
 305                 310                 315                 320
 Asn Gly Phe Xaa Arg Lys Thr Leu Lys Ser Ala Met Ala Thr Tyr Ser
                 325                 330                 335    
 Ala Thr Cys Ala Asn Asn Ser Pro Ala Gln Gly Ile Asn Met Ala Asn
             340                 345                 350        
 Ser Ile Ala Asn Leu Arg Leu Lys Ala Lys Glu Tyr Ser Leu Gln Arg
         355                 360                 365            
 Asn Gln Val Pro Thr Val Asn
     370                 375



      <210> 2920
      <211> 478
      <212> PRT
      <213> Homo sapiens


      <400> 2920
 Met Gly Lys Lys Gln Asn Arg Lys Thr Gly Asn Ser Lys Lys Gln Ser
   1               5                  10                  15    
 Thr Ser Pro Pro Pro Lys Glu Arg Ser Ser Ser Pro Ala Met Glu Gln
              20                  25                  30        
 Ser Trp Thr Glu Asn Asp Phe Asp Glu Leu Arg Glu Glu Gly Phe Arg
          35                  40                  45            
 Arg Ser Asn Tyr Ser Glu Leu Arg Glu Asp Ile Gln Thr Lys Gly Lys
      50                  55                  60                
 Glu Val Glu Asn Phe Glu Lys Asn Leu Glu Glu Cys Ile Thr Arg Val
  65                  70                  75                  80
 Thr Asn Thr Glu Lys Cys Leu Lys Glu Leu Met Glu Leu Lys Thr Lys
                  85                  90                  95    
 Ala Arg Glu Leu Arg Glu Glu Cys Arg Ser Leu Arg Ser Arg Cys Asp
             100                 105                 110        
 Leu Leu Glu Glu Arg Val Ser Ala Met Glu Asp Glu Met Asn Glu Met
         115                 120                 125            
 Lys Phe Gln Leu Lys Gly Ser Ser Ala Ser Tyr Cys Val Leu Ala Gly
     130                 135                 140                
 Met Glu Ser Leu Trp Asn Ser Ser Val Pro Val Cys Glu Arg Lys Ser
 145                 150                 155                 160
 Cys Glu Thr Pro Pro Val Pro Val Asn Gly Met Val His Val Ile Thr
                 165                 170                 175    
 Asp Ile His Val Gly Ser Arg Ile Asn Tyr Ser Cys Thr Thr Gly His
             180                 185                 190        
 Arg Leu Ile Gly His Ser Ser Ala Glu Cys Ile Leu Ser Gly Asn Thr
         195                 200                 205            
 Ala His Trp Ser Thr Lys Pro Pro Ile Cys Gln Arg Ile Pro Cys Gly
     210                 215                 220                
 Leu Pro Pro Thr Ile Ala Asn Gly Asp Phe Ile Ser Thr Asn Arg Glu
 225                 230                 235                 240
 Asn Phe His Tyr Gly Ser Val Val Thr Tyr Arg Cys Asn Leu Gly Ser
                 245                 250                 255    
 Arg Gly Arg Lys Val Phe Glu Leu Val Val Cys Gln Pro Pro Pro Glu
             260                 265                 270        
 Ile Leu His Gly Glu His Thr Pro Ser His Gln Asp Asn Phe Ser Pro
         275                 280                 285            
 Gly Gln Glu Val Phe Tyr Ser Cys Glu Pro Gly Tyr Asp Leu Arg Gly
     290                 295                 300                
 Ala Ala Ser Leu His Cys Thr Pro Gln Gly Asp Trp Ser Pro Glu Ala
 305                 310                 315                 320
 Pro Arg Cys Ala Val Lys Ser Cys Asp Asp Phe Leu Gly Gln Leu Pro
                 325                 330                 335    
 His Gly Arg Val Leu Phe Pro Leu Asn Leu Gln Leu Gly Ala Lys Val
             340                 345                 350        
 Ser Phe Val Cys Asp Glu Gly Arg Asp Thr Ala Val Pro His Tyr Ala
         355                 360                 365            
 Phe Pro Ala Val Ala Leu Arg Leu Phe Pro Val Thr Ser Leu Ile Leu
     370                 375                 380                
 Ser Tyr Leu Ile Phe Ser Gly Asp Leu Gln Asn Gly Ile Thr Gly Ser
 385                 390                 395                 400
 Pro Pro Thr Asp Ser Ser Gly Ile Leu Pro Trp Tyr Glu Pro Glu Asp
                 405                 410                 415    
 Lys Leu Lys Thr Arg Val Val Cys Ser Pro Lys Ser Gln Gly Val Arg
             420                 425                 430        
 Thr Leu Gln Ala Glu Glu Ser Glu Gly Arg Val Ile Ser Ser Ser His
         435                 440                 445            
 Val Ile Lys Arg Val Ile Gln Thr Ile Lys Glu Glu Thr Val Arg Arg
     450                 455                 460                
 Ser Leu Thr Arg Arg Arg Pro Phe Asn Asp Ser Glu Ser Ser
 465                 470                 475            



      <210> 2921
      <211> 931
      <212> PRT
      <213> Homo sapiens


      <400> 2921
 Cys Ala Gln Ala Ala Leu Pro Glu Met Pro Arg Gly Ser Arg Ala Arg
   1               5                  10                  15    
 Gly Ser Lys Arg Lys Arg Ser Trp Asn Thr Glu Cys Pro Ser Phe Pro
              20                  25                  30        
 Gly Glu Arg Pro Leu Gln Val Arg Arg Ala Gly Leu Arg Thr Ala Gly
          35                  40                  45            
 Ala Ala Ala Ser Leu Ser Glu Ala Trp Leu Arg Cys Gly Glu Gly Phe
      50                  55                  60                
 Gln Asn Thr Ser Gly Asn Pro Ser Leu Thr Ala Glu Glu Lys Thr Ile
  65                  70                  75                  80
 Thr Glu Lys His Leu Glu Leu Cys Pro Arg Pro Lys Gln Glu Thr Thr
                  85                  90                  95    
 Thr Ser Lys Ser Thr Ser Gly Leu Thr Asp Ile Thr Trp Ser Ser Ser
             100                 105                 110        
 Gly Ser Asp Leu Ser Asp Glu Asp Lys Thr Leu Ser Gln Leu Gln Arg
         115                 120                 125            
 Asp Glu Leu Gln Phe Ile Asp Trp Glu Ile Asp Ser Asp Arg Ala Glu
     130                 135                 140                
 Ala Ser Asp Cys Asp Glu Phe Glu Asp Asp Glu Gly Ala Val Glu Ile
 145                 150                 155                 160
 Ser Asp Cys Ala Ser Cys Ala Ser Asn Gln Ser Leu Thr Ser Asp Glu
                 165                 170                 175    
 Lys Leu Ser Glu Leu Pro Lys Pro Ser Ser Ile Glu Ile Leu Glu Tyr
             180                 185                 190        
 Ser Ser Asp Ser Glu Lys Glu Asp Asp Leu Glu Asn Val Leu Leu Ile
         195                 200                 205            
 Asp Ser Glu Ser Pro His Lys Tyr His Val Gln Phe Ala Ser Asp Ala
     210                 215                 220                
 Arg Gln Ile Met Glu Arg Leu Ile Asp Pro Arg Thr Lys Ser Thr Glu
 225                 230                 235                 240
 Thr Ile Leu His Thr Pro Gln Lys Pro Thr Ala Lys Phe Pro Arg Thr
                 245                 250                 255    
 Pro Glu Asn Ser Ala Lys Lys Lys Leu Leu Arg Gly Gly Leu Ala Glu
             260                 265                 270        
 Arg Leu Asn Gly Leu Gln Asn Arg Glu Arg Ser Ala Ile Ser Leu Trp
         275                 280                 285            
 Arg His Gln Cys Ile Ser Tyr Gln Lys Thr Leu Ser Gly Arg Lys Ser
     290                 295                 300                
 Gly Val Leu Thr Val Lys Ile Leu Glu Leu His Glu Glu Cys Ala Met
 305                 310                 315                 320
 Gln Val Ala Met Cys Glu Gln Leu Leu Gly Ser Pro Ala Thr Ser Ser
                 325                 330                 335    
 Ser Gln Ser Val Ala Pro Arg Pro Gly Ala Gly Leu Lys Val Leu Phe
             340                 345                 350        
 Thr Lys Glu Thr Ala Gly Tyr Leu Arg Gly Arg Pro Gln Asp Thr Val
         355                 360                 365            
 Arg Ile Phe Pro Pro Trp Gln Lys Leu Ile Ile Pro Ser Gly Ser Cys
     370                 375                 380                
 Pro Val Ile Leu Asn Thr Tyr Phe Cys Glu Lys Val Val Ala Lys Glu
 385                 390                 395                 400
 Asp Ser Glu Lys Thr Cys Glu Val Tyr Cys Pro Asp Ile Pro Leu Pro
                 405                 410                 415    
 Arg Arg Ser Ile Ser Leu Ala Gln Met Phe Val Ile Lys Gly Leu Thr
             420                 425                 430        
 Asn Asn Ser Pro Glu Ile Gln Val Val Cys Ser Gly Val Ala Thr Thr
         435                 440                 445            
 Gly Thr Ala Trp Thr His Gly His Lys Glu Ala Lys Gln Arg Ile Pro
     450                 455                 460                
 Thr Ser Thr Pro Leu Arg Asp Ser Leu Leu Asp Val Val Glu Ser Gln
 465                 470                 475                 480
 Gly Ala Ala Ser Trp Pro Gly Ala Gly Val Arg Val Val Val Gln Arg
                 485                 490                 495    
 Val Tyr Ser Leu Pro Ser Arg Asp Ser Thr Arg Gly Gln Gln Gly Ala
             500                 505                 510        
 Ser Ser Gly His Thr Asp Pro Ala Gly Thr Arg Ala Cys Leu Leu Val
         515                 520                 525            
 Gln Asp Ala Cys Gly Met Phe Gly Glu Val His Leu Glu Phe Thr Met
     530                 535                 540                
 Ser Lys Ala Arg Gln Leu Glu Gly Lys Ser Cys Ser Leu Val Gly Met
 545                 550                 555                 560
 Lys Val Leu Gln Lys Val Thr Arg Gly Arg Thr Ala Gly Ile Phe Ser
                 565                 570                 575    
 Leu Ile Asp Thr Leu Trp Pro Pro Ala Ile Pro Leu Lys Thr Pro Gly
             580                 585                 590        
 Arg Asp Gln Pro Cys Glu Glu Ile Lys Thr His Leu Pro Pro Pro Ala
         595                 600                 605            
 Leu Cys Tyr Ile Leu Thr Ala His Pro Asn Leu Gly Gln Ile Asp Ile
     610                 615                 620                
 Ile Asp Glu Asp Pro Ile Tyr Lys Leu Tyr Gln Pro Pro Val Thr Arg
 625                 630                 635                 640
 Cys Leu Arg Asp Ile Leu Gln Met Asn Asp Leu Gly Thr Arg Cys Ser
                 645                 650                 655    
 Phe Tyr Ala Thr Val Ile Tyr Gln Lys Pro Gln Leu Lys Ser Leu Leu
             660                 665                 670        
 Leu Leu Glu Gln Arg Glu Ile Trp Leu Leu Val Thr Asp Val Thr Leu
         675                 680                 685            
 Gln Thr Lys Glu Glu Arg Asp Pro Arg Leu Pro Lys Thr Leu Leu Val
     690                 695                 700                
 Tyr Val Ala Pro Leu Cys Val Leu Gly Ser Glu Val Leu Glu Ala Leu
 705                 710                 715                 720
 Ala Gly Ala Ala Pro His Ser Leu Phe Phe Lys Asp Ala Leu Arg Asp
                 725                 730                 735    
 Gln Gly Arg Ile Val Cys Ala Glu Arg Thr Val Leu Leu Leu Gln Lys
             740                 745                 750        
 Pro Leu Leu Ser Val Val Ser Gly Ala Ser Ser Cys Glu Leu Pro Gly
         755                 760                 765            
 Pro Val Met Leu Asp Ser Leu Asp Ser Ala Thr Pro Val Asn Ser Ile
     770                 775                 780                
 Cys Ser Val Gln Gly Thr Val Val Gly Val Asp Glu Ser Thr Ala Phe
 785                 790                 795                 800
 Ser Trp Pro Val Cys Asp Met Cys Gly Asn Gly Arg Leu Glu Gln Arg
                 805                 810                 815    
 Pro Glu Asp Arg Gly Ala Phe Ser Cys Gly Asp Cys Ser Arg Val Val
             820                 825                 830        
 Thr Ser Pro Val Leu Lys Arg His Leu Gln Val Phe Leu Asp Cys Arg
         835                 840                 845            
 Ser Arg Pro Gln Cys Arg Val Lys Val Lys Leu Leu Gln Arg Ser Ile
     850                 855                 860                
 Ser Ser Leu Leu Arg Phe Ala Ala Gly Glu Asp Gly Ser Tyr Glu Val
 865                 870                 875                 880
 Lys Ser Val Leu Gly Lys Glu Val Gly Leu Leu Asn Cys Phe Val Gln
                 885                 890                 895    
 Ser Val Thr Ala His Pro Thr Ser Cys Ile Gly Leu Glu Glu Ile Glu
             900                 905                 910        
 Leu Leu Ser Ala Gly Gly Ala Ser Cys Gln Asn Thr Ser Arg Leu Pro
         915                 920                 925            
 Gln Asp Leu
     930    



      <210> 2922
      <211> 479
      <212> PRT
      <213> Homo sapiens


      <400> 2922
 Met Tyr Leu Met Gln Gly His Gln Ser Tyr Arg Ile Lys Gly Gln Pro
   1               5                  10                  15    
 Cys Ser Ser Ile Thr Val Gly Ser Pro Leu Trp Glu Ser Ser Ala Thr
              20                  25                  30        
 Asn Ser Trp Ala Ala Thr Glu Thr Met Thr Tyr Gln Asp Arg Ser Arg
          35                  40                  45            
 Ile Met Asn Tyr Pro Leu Ala Asn Ser Lys Gly Ser Leu Lys Ala Trp
      50                  55                  60                
 Ile Phe Ser Arg Ser Leu Glu Val Glu Lys Ser Lys Ile Lys Ala Leu
  65                  70                  75                  80
 Asn Leu Val Arg Ala Phe Leu Leu Ser His Pro Thr Ala Glu Gly Gly
                  85                  90                  95    
 Arg Ala Gly Ala His Thr Arg Glu Arg Glu Arg Asp Asp Lys Leu Gly
             100                 105                 110        
 Asn Tyr Ile Ser Leu Ile Leu Pro Thr Val Phe Ser Pro Asp Ser Thr
         115                 120                 125            
 Asn Glu Arg His Leu His Glu Ile Trp Leu Gly Arg Lys Gly Glu Ala
     130                 135                 140                
 Ile Val Phe Leu Arg Gln Gln Gln Met Ala Asp Met Glu Phe Cys Leu
 145                 150                 155                 160
 Lys Leu Leu Gly Val Leu Leu Lys Ile Leu Gln Leu Ala Leu Gln Ala
                 165                 170                 175    
 Ala Glu Ser Asn Gly Ser Gly Phe Leu Val Ile Pro Ala Leu Pro Asp
             180                 185                 190        
 Phe Leu Lys Glu Arg Met Gln Gln Gln Gly Thr Ser Leu Glu Ala Glu
         195                 200                 205            
 Ile Lys Pro Leu Ser Asp Ala Lys Pro Ala Tyr Ala Leu Ile Trp Asp
     210                 215                 220                
 Phe Pro Ala Ser Arg Thr Met Arg Asn Lys Phe Leu Leu Phe Val Asn
 225                 230                 235                 240
 Tyr Pro Val Tyr Gly Leu Gln Glu Lys Gly Glu Glu Ser Leu Gln Val
                 245                 250                 255    
 Ala Leu Cys Gly Glu Ser His Pro Thr Gly Met Val Ala Phe Ile Lys
             260                 265                 270        
 Glu Cys Ser Gln Pro Gly Glu Pro Ser Pro Gln Gly Ser Lys Ala Asn
         275                 280                 285            
 Arg Tyr Phe Thr Leu Ser Phe Leu Leu Pro Ser His Val Leu Pro Val
     290                 295                 300                
 Phe Ser Ile Gly Gln Ala Gln Pro Arg Ile Gln Lys Thr Arg Glu Ser
 305                 310                 315                 320
 Ala Asp Thr Ala His Pro Val Cys Pro Gln Thr Lys Asp Gly His Val
                 325                 330                 335    
 Arg Ile Pro Gln Arg Leu Val Asp Cys Ala Ala Ala Asp Val Gly Arg
             340                 345                 350        
 Arg Arg Phe Phe Gly Lys Gln Gly Gly Phe Glu Gln Thr Asn Asp Leu
         355                 360                 365            
 Ala Arg Thr Gly Ile Val Cys Ala Trp Gln Lys Gln Arg Arg Asp Ser
     370                 375                 380                
 Arg Asp Val Thr Met Gly Leu Gln His Leu Ser Ser Val Thr Ser Thr
 385                 390                 395                 400
 Leu Arg Arg Arg Pro Ala Leu Ala Gln Met Leu Leu Glu Pro Ser Glu
                 405                 410                 415    
 Ala Cys Asn Leu Gly Ser Phe Leu Val Ile Ser His Met Val Val Asp
             420                 425                 430        
 Asn Gly Cys Trp Gly Leu Gly Leu Glu Ala Ser Glu Val Thr Val Asp
         435                 440                 445            
 Ala Gly Cys Gln Pro Gly Ala Gln Leu Gly Cys Gln Leu Glu Arg Leu
     450                 455                 460                
 His Met Asp Ser Pro Cys Ser Leu Asp Cys Ala Gln Ala Gly Gly
 465                 470                 475                



      <210> 2923
      <211> 1707
      <212> PRT
      <213> Homo sapiens


      <400> 2923
 Met Phe Asn Lys Ser Phe Gly Thr Pro Phe Gly Gly Gly Thr Gly Gly
   1               5                  10                  15    
 Phe Gly Thr Thr Ser Thr Phe Gly Gln Asn Thr Gly Phe Gly Thr Thr
              20                  25                  30        
 Ser Gly Gly Ala Phe Gly Thr Ser Ala Phe Gly Ser Ser Asn Asn Thr
          35                  40                  45            
 Gly Gly Leu Phe Gly Asn Ser Gln Thr Lys Pro Gly Gly Leu Phe Gly
      50                  55                  60                
 Thr Ser Ser Phe Ser Gln Pro Ala Thr Ser Thr Ser Thr Gly Phe Gly
  65                  70                  75                  80
 Phe Gly Thr Ser Thr Gly Thr Ala Asn Thr Leu Phe Gly Thr Ala Ser
                  85                  90                  95    
 Thr Gly Thr Ser Leu Phe Ser Ser Gln Asn Asn Ala Phe Ala Gln Asn
             100                 105                 110        
 Lys Pro Thr Gly Phe Gly Asn Phe Gly Thr Ser Thr Ser Ser Gly Gly
         115                 120                 125            
 Leu Phe Gly Thr Thr Asn Thr Thr Ser Asn Pro Phe Gly Ser Thr Ser
     130                 135                 140                
 Gly Ser Leu Phe Gly Pro Ser Ser Phe Thr Ala Ala Pro Thr Gly Thr
 145                 150                 155                 160
 Thr Ile Lys Phe Asn Pro Pro Thr Gly Thr Asp Thr Met Val Lys Ala
                 165                 170                 175    
 Gly Val Ser Thr Asn Ile Ser Thr Lys His Gln Cys Ile Thr Ala Met
             180                 185                 190        
 Lys Glu Tyr Glu Ser Lys Ser Leu Glu Glu Leu Arg Leu Glu Asp Tyr
         195                 200                 205            
 Gln Ala Asn Arg Lys Gly Pro Gln Asn Gln Val Gly Ala Gly Thr Thr
     210                 215                 220                
 Thr Gly Leu Phe Gly Ser Ser Pro Ala Thr Ser Ser Ala Thr Gly Leu
 225                 230                 235                 240
 Phe Ser Ser Ser Thr Thr Asn Ser Gly Phe Ala Tyr Gly Gln Asn Lys
                 245                 250                 255    
 Thr Ala Phe Gly Thr Ser Thr Thr Gly Phe Gly Thr Asn Pro Gly Gly
             260                 265                 270        
 Leu Phe Gly Gln Gln Asn Gln Gln Thr Thr Ser Leu Phe Ser Lys Pro
         275                 280                 285            
 Phe Gly Gln Ala Thr Thr Thr Gln Asn Thr Gly Phe Ser Phe Gly Asn
     290                 295                 300                
 Thr Ser Thr Ile Gly Gln Pro Ser Thr Asn Thr Met Gly Leu Phe Gly
 305                 310                 315                 320
 Val Thr Gln Ala Ser Gln Pro Gly Gly Leu Phe Gly Thr Ala Thr Asn
                 325                 330                 335    
 Thr Ser Thr Gly Thr Ala Phe Gly Thr Gly Thr Gly Leu Phe Gly Gln
             340                 345                 350        
 Thr Asn Thr Gly Phe Gly Ala Val Gly Ser Thr Leu Phe Gly Asn Asn
         355                 360                 365            
 Lys Leu Thr Thr Phe Gly Ser Ser Thr Thr Ser Ala Pro Ser Phe Gly
     370                 375                 380                
 Thr Thr Ser Gly Gly Leu Phe Gly Phe Gly Thr Asn Thr Ser Gly Asn
 385                 390                 395                 400
 Ser Ile Phe Gly Ser Lys Pro Ala Pro Gly Thr Leu Gly Thr Gly Leu
                 405                 410                 415    
 Gly Ala Gly Phe Gly Thr Ala Leu Gly Ala Gly Gln Ala Ser Leu Phe
             420                 425                 430        
 Gly Asn Asn Gln Pro Lys Ile Gly Gly Pro Leu Gly Thr Gly Ala Phe
         435                 440                 445            
 Gly Ala Pro Gly Phe Asn Thr Thr Thr Ala Thr Leu Gly Phe Gly Ala
     450                 455                 460                
 Pro Gln Ala Pro Val Ala Leu Thr Asp Pro Asn Ala Ser Ala Ala Gln
 465                 470                 475                 480
 Gln Ala Val Leu Gln Gln His Ile Asn Ser Leu Thr Tyr Ser Pro Phe
                 485                 490                 495    
 Gly Asp Ser Pro Leu Phe Arg Asn Pro Met Ser Asp Pro Lys Lys Lys
             500                 505                 510        
 Glu Glu Arg Leu Lys Pro Thr Asn Pro Ala Ala Gln Lys Ala Leu Thr
         515                 520                 525            
 Thr Pro Thr His Tyr Lys Leu Thr Pro Arg Pro Ala Thr Arg Val Arg
     530                 535                 540                
 Pro Lys Ala Leu Gln Thr Thr Gly Thr Ala Lys Ser His Leu Phe Asp
 545                 550                 555                 560
 Gly Leu Asp Asp Asp Glu Pro Ser Leu Ala Asn Gly Ala Phe Met Pro
                 565                 570                 575    
 Lys Lys Ser Ile Lys Lys Leu Val Leu Lys Asn Leu Asn Asn Ser Asn
             580                 585                 590        
 Leu Phe Ser Pro Val Asn Arg Asp Ser Glu Asn Leu Ala Ser Pro Ser
         595                 600                 605            
 Glu Tyr Pro Glu Asn Gly Glu Arg Phe Ser Phe Leu Ser Lys Pro Val
     610                 615                 620                
 Asp Glu Asn His Gln Gln Asp Gly Asp Glu Asp Ser Leu Val Ser His
 625                 630                 635                 640
 Phe Tyr Thr Asn Pro Ile Ala Lys Pro Ile Pro Gln Thr Pro Glu Ser
                 645                 650                 655    
 Ala Gly Asn Lys His Ser Asn Ser Asn Ser Val Asp Asp Thr Ile Val
             660                 665                 670        
 Ala Leu Asn Met Arg Ala Ala Leu Arg Asn Gly Leu Glu Gly Ser Ser
         675                 680                 685            
 Glu Glu Thr Ser Phe His Asp Glu Ser Leu Gln Asp Asp Arg Glu Glu
     690                 695                 700                
 Ile Glu Asn Asn Ser Tyr His Met His Pro Ala Gly Ile Ile Leu Thr
 705                 710                 715                 720
 Lys Val Gly Tyr Tyr Thr Ile Pro Ser Met Asp Asp Leu Ala Lys Ile
                 725                 730                 735    
 Thr Asn Val Phe Gly Glu Cys Ile Val Ser Asp Phe Thr Ile Gly Arg
             740                 745                 750        
 Lys Gly Tyr Gly Ser Ile Tyr Phe Glu Gly Asp Val Asn Leu Thr Asn
         755                 760                 765            
 Leu Asn Leu Asp Asp Ile Val His Ile Arg Arg Lys Glu Val Val Val
     770                 775                 780                
 Tyr Leu Asp Asp Asn Gln Lys Pro Pro Val Gly Glu Gly Leu Asn Arg
 785                 790                 795                 800
 Lys Ala Glu Val Thr Leu Asp Gly Val Trp Pro Thr Asp Lys Thr Ser
                 805                 810                 815    
 Arg Cys Leu Ile Lys Ser Pro Asp Arg Leu Ala Asp Ile Asn Tyr Glu
             820                 825                 830        
 Gly Arg Leu Glu Ala Val Ser Arg Lys Gln Gly Ala Glu Phe Lys Glu
         835                 840                 845            
 Tyr Arg Pro Glu Thr Gly Ser Trp Val Phe Lys Val Ser His Phe Ser
     850                 855                 860                
 Lys Tyr Gly Leu Gln Asp Ser Asp Glu Glu Glu Glu Glu His Pro Ser
 865                 870                 875                 880
 Lys Thr Ser Thr Lys Lys Leu Lys Thr Ala Pro Leu Pro Pro Ala Ser
                 885                 890                 895    
 Gln Thr Thr Pro Leu Gln Met Ala Leu Asn Gly Lys Pro Ala Pro Pro
             900                 905                 910        
 Pro Gln Ser Gln Ser Pro Glu Val Glu Gln Leu Gly Arg Val Val Glu
         915                 920                 925            
 Leu Asp Ser Asp Met Val Asp Ile Thr Gln Glu Pro Val Leu Asp Thr
     930                 935                 940                
 Met Leu Glu Glu Ser Met Pro Glu Asp Gln Glu Pro Val Ser Ala Ser
 945                 950                 955                 960
 Thr His Ile Ala Ser Ser Leu Gly Ile Asn Pro His Val Leu Gln Ile
                 965                 970                 975    
 Met Lys Ala Ser Leu Leu Thr Asp Glu Glu Asp Val Asp Met Ala Leu
             980                 985                 990        
 Asp Gln Arg Phe Ser Arg Leu Pro Ser Lys Ala Asp Thr Ser Gln Glu
         995                1000                1005            
 Ile Cys Ser Pro Arg Leu Pro Ile Ser Ala Ser His Ser Ser Lys Thr
    1010                1015                1020                
 Arg Ser Leu Val Gly Gly Leu Leu Gln Ser Lys Phe Thr Ser Gly Ala
1025                1030                1035                1040
 Phe Leu Ser Pro Ser Val Ser Val Gln Glu Cys Arg Thr Pro Arg Ala
                1045                1050                1055    
 Ala Ser Leu Met Asn Ile Pro Ser Thr Ser Ser Trp Ser Val Pro Pro
            1060                1065                1070        
 Pro Leu Thr Ser Val Phe Thr Met Pro Ser Pro Ala Pro Glu Val Pro
        1075                1080                1085            
 Leu Lys Thr Val Gly Thr Arg Arg Gln Leu Gly Leu Val Pro Arg Glu
    1090                1095                1100                
 Lys Ser Val Thr Tyr Gly Lys Gly Lys Leu Leu Met Asp Met Ala Leu
1105                1110                1115                1120
 Phe Met Gly Arg Ser Phe Arg Val Gly Trp Gly Pro Asn Trp Thr Leu
                1125                1130                1135    
 Ala Asn Ser Gly Glu Gln Leu Asn Gly Ser His Glu Leu Glu Asn His
            1140                1145                1150        
 Gln Ile Ala Asp Ser Met Glu Phe Gly Phe Leu Pro Asn Pro Val Ala
        1155                1160                1165            
 Val Lys Pro Leu Thr Glu Ser Pro Phe Lys Val His Leu Glu Lys Leu
    1170                1175                1180                
 Ser Leu Arg Gln Arg Lys Pro Asp Glu Asp Met Lys Leu Tyr Gln Thr
1185                1190                1195                1200
 Pro Leu Glu Leu Lys Leu Lys His Ser Thr Val His Val Asp Glu Leu
                1205                1210                1215    
 Cys Pro Leu Ile Val Pro Asn Leu Gly Val Ala Val Ile His Asp Tyr
            1220                1225                1230        
 Ala Asp Trp Val Lys Glu Ala Ser Gly Asp Leu Pro Glu Ala Gln Ile
        1235                1240                1245            
 Val Lys His Trp Ser Leu Thr Trp Thr Leu Cys Glu Ala Leu Trp Ala
    1250                1255                1260                
 His Leu Lys Glu Leu Asp Ser Gln Leu Asn Glu Pro Arg Glu Tyr Ile
1265                1270                1275                1280
 Gln Ile Leu Glu Arg Arg Arg Ala Phe Ser Arg Trp Leu Ser Cys Thr
                1285                1290                1295    
 Ala Thr Pro Gln Ile Glu Glu Glu Val Ser Leu Thr Gln Lys Asn Ser
            1300                1305                1310        
 Pro Val Glu Ala Val Phe Ser Tyr Leu Thr Gly Lys Arg Ile Ser Glu
        1315                1320                1325            
 Ala Cys Ser Leu Ala Gln Gln Ser Gly Asp His Arg Leu Ala Leu Leu
    1330                1335                1340                
 Leu Ser Gln Phe Val Gly Ser Gln Ser Val Arg Glu Leu Leu Thr Met
1345                1350                1355                1360
 Gln Leu Val Asp Trp His Gln Leu Gln Ala Asp Ser Phe Ile Gln Asp
                1365                1370                1375    
 Glu Arg Leu Arg Ile Phe Ala Leu Leu Ala Gly Lys Pro Val Trp Gln
            1380                1385                1390        
 Leu Ser Glu Lys Lys Gln Ile Asn Val Cys Ser Gln Leu Asp Trp Lys
        1395                1400                1405            
 Arg Ser Leu Ala Ile His Leu Trp Tyr Leu Leu Pro Pro Thr Ala Ser
    1410                1415                1420                
 Ile Ser Arg Ala Leu Ser Met Tyr Glu Glu Ala Phe Gln Asn Thr Ser
1425                1430                1435                1440
 Asp Ser Asp Arg Tyr Ala Cys Ser Pro Leu Pro Ser Tyr Leu Glu Gly
                1445                1450                1455    
 Ser Gly Cys Val Ile Ala Glu Glu Gln Asn Tyr Gln Thr Pro Leu Arg
            1460                1465                1470        
 Asp Val Cys Phe His Leu Arg Lys Thr Arg Thr Ser Asp Arg His Tyr
        1475                1480                1485            
 Asp Leu Asn Gln Ala Cys Trp Ser Pro Glu Ser Ile Thr Ala Asp Pro
    1490                1495                1500                
 Leu Asp Tyr Arg Leu Ser Trp His Leu Trp Glu Val Leu Arg Ala Leu
1505                1510                1515                1520
 Asn Tyr Thr His Leu Ser Ala Gln Cys Glu Gly Val Leu Gln Ala Ser
                1525                1530                1535    
 Tyr Ala Gly Gln Leu Glu Ser Glu Gly Leu Trp Glu Trp Ala Ile Phe
            1540                1545                1550        
 Val Leu Leu His Ile Asp Asn Ser Gly Ile Arg Glu Lys Ala Val Arg
        1555                1560                1565            
 Glu Leu Leu Thr Arg His Cys Gln Leu Leu Glu Thr Pro Glu Ser Trp
    1570                1575                1580                
 Ala Lys Glu Thr Phe Leu Thr Gln Lys Leu Arg Val Pro Ala Lys Trp
1585                1590                1595                1600
 Ile His Glu Ala Lys Ala Val Arg Ala His Met Glu Ser Asp Lys His
                1605                1610                1615    
 Leu Glu Ala Leu Cys Leu Phe Lys Ala Glu His Trp Asn Arg Cys His
            1620                1625                1630        
 Lys Leu Ile Ile Arg His Leu Ala Ser Asp Ala Ile Ile Asn Glu Asn
        1635                1640                1645            
 Tyr Asp Tyr Leu Lys Gly Phe Leu Glu Asp Leu Ala Pro Pro Glu Arg
    1650                1655                1660                
 Ser Ser Leu Ile Gln Asp Trp Glu Thr Ser Gly Leu Val Tyr Leu Asp
1665                1670                1675                1680
 Tyr Ile Arg Val Ile Glu Met Leu Arg His Ile Gln Gln Val Ile Ala
                1685                1690                1695    
 Gln Val Met Thr Trp Ser Ser Tyr Thr Ser Lys
            1700                1705        



      <210> 2924
      <211> 280
      <212> PRT
      <213> Homo sapiens


      <400> 2924
 Asn Pro Phe Ser Trp Lys Asn Phe Val Asp Thr Val Arg Asp Thr Thr
   1               5                  10                  15    
 Ala Ala His Gln Ala Leu Leu Val Ala Lys Asn Val Asp Ser Phe Pro
              20                  25                  30        
 Gln Asn Gln Glu Arg Phe Gly Gly Gly His Ile Asp Val Trp Trp Ile
          35                  40                  45            
 Val His Asp Gly Gly Met Leu Met Leu Leu Pro Phe Leu Leu Arg Gln
      50                  55                  60                
 His Lys Val Trp Arg Lys Cys Arg Met Arg Ile Phe Thr Val Ala Gln
  65                  70                  75                  80
 Val Asp Asp Asn Ser Ile Gln Met Lys Lys Asp Leu Gln Met Phe Leu
                  85                  90                  95    
 Tyr His Leu Arg Ile Ser Ala Glu Val Glu Val Val Glu Met Val Glu
             100                 105                 110        
 Asn Asp Ile Ser Ala Phe Thr Tyr Glu Arg Thr Leu Met Met Glu Gln
         115                 120                 125            
 Arg Ser Gln Met Leu Lys Gln Met Gln Leu Ser Lys Asn Glu Gln Glu
     130                 135                 140                
 Arg Glu Ala Gln Leu Ile His Asp Arg Asn Thr Ala Ser His Thr Ala
 145                 150                 155                 160
 Ala Ala Ala Arg Thr Gln Ala Pro Pro Thr Pro Asp Lys Val Gln Met
                 165                 170                 175    
 Thr Trp Thr Arg Glu Lys Leu Ile Ala Glu Lys Tyr Arg Ser Arg Asp
             180                 185                 190        
 Thr Ser Leu Ser Gly Phe Lys Asp Leu Phe Ser Met Lys Pro Asp Gln
         195                 200                 205            
 Ser Asn Val Arg Arg Met His Thr Ala Val Lys Leu Asn Gly Val Val
     210                 215                 220                
 Leu Asn Lys Ser Gln Asp Ala Gln Leu Val Leu Leu Asn Met Pro Gly
 225                 230                 235                 240
 Pro Pro Lys Asn Arg Gln Gly Asp Glu Asn Tyr Met Glu Phe Leu Glu
                 245                 250                 255    
 Val Leu Thr Glu Gly Leu Asn Arg Val Leu Leu Val Arg Gly Gly Gly
             260                 265                 270        
 Arg Glu Val Ile Thr Ile Tyr Ser
         275                 280



      <210> 2925
      <211> 499
      <212> PRT
      <213> Homo sapiens


      <400> 2925
 Met Gly Asp Phe Asn Thr Pro Leu Ser Thr Leu Asp Arg Ser Thr Arg
   1               5                  10                  15    
 Gln Lys Val Asn Lys Asp Thr Gln Glu Leu Asn Ser Ala Leu His Gln
              20                  25                  30        
 Ala Asp Leu Ile Asp Ile Tyr Arg Ser Leu His Ala Lys Ser Thr Glu
          35                  40                  45            
 Tyr Thr Phe Phe Ser Ala Pro His His Thr Tyr Ser Lys Ile Asp His
      50                  55                  60                
 Ile Leu Gly Ser Lys Ala Leu Leu Ser Lys Cys Lys Arg Thr Glu Ile
  65                  70                  75                  80
 Ile Thr Asn Tyr Leu Ser Asp His Ser Ala Ile Lys Leu Glu Leu Arg
                  85                  90                  95    
 Ile Lys Asn Leu Thr Gln Asn Arg Ser Thr Thr Trp Lys Leu Asn Asn
             100                 105                 110        
 Leu Leu Leu Asn Asp Tyr Trp Ile His Asp Glu Met Lys Ala Glu Ile
         115                 120                 125            
 Lys Met Phe Phe Glu Thr Asn Glu Asn Lys Asp Thr Thr Tyr Gln Asn
     130                 135                 140                
 Leu Trp Asp Ala Phe Lys Ala Thr Ala Ser Lys Thr Asn Lys Glu Lys
 145                 150                 155                 160
 Glu Lys Asn Gln Ile Asp Thr Ile Lys Asn Asp Lys Gly Asp Ile Thr
                 165                 170                 175    
 Thr Asp Pro Thr Glu Ile Gln Thr Thr Ile Arg Glu Tyr Tyr Lys His
             180                 185                 190        
 Leu Tyr Ala Asn Lys Leu Glu Asn Leu Glu Glu Met Asp Lys Phe Leu
         195                 200                 205            
 Asp Thr Tyr Thr Leu Pro Arg Leu Asn Gln Glu Glu Val Glu Ser Leu
     210                 215                 220                
 Asn Arg Pro Ile Thr Gly Ala Glu Ile Val Ala Ile Ile Asn Ser Leu
 225                 230                 235                 240
 Pro Thr Lys Lys Ser Pro Gly Pro Asp Gly Phe Thr Ala Glu Phe Tyr
                 245                 250                 255    
 Gln Arg Tyr Lys Glu Glu Leu His Ile Asn Arg Ala Lys Asp Lys Asn
             260                 265                 270        
 His Met Ile Ile Ser Ile Asp Ala Glu Lys Ala Phe Asp Lys Ile Gln
         275                 280                 285            
 Gln Pro Phe Met Leu Lys Thr Leu Asn Lys Leu Gly Ile Asp Gly Thr
     290                 295                 300                
 Tyr Phe Lys Ile Ile Arg Ala Ile Tyr Asp Lys Pro Thr Ala Asn Ile
 305                 310                 315                 320
 Ile Leu Asn Gly Gln Lys Leu Glu Ala Phe Pro Leu Lys Thr Gly Thr
                 325                 330                 335    
 Arg Gln Gly Cys Pro Leu Ser Pro Leu Leu Phe Asn Ile Val Leu Glu
             340                 345                 350        
 Val Leu Ala Arg Ala Ile Arg Gln Glu Lys Glu Ile Lys Gly Ile Gln
         355                 360                 365            
 Leu Gly Lys Glu Glu Val Lys Leu Ser Leu Phe Ala Asp Asp Met Thr
     370                 375                 380                
 Val Tyr Leu Glu Asn Pro Ile Val Ser Ala Gln Asn Leu Leu Lys Leu
 385                 390                 395                 400
 Ile Ser Asn Phe Ser Lys Val Ser Gly Tyr Lys Ile Asn Val Gln Lys
                 405                 410                 415    
 Ser Gln Ala Phe Leu Tyr Thr Asn Asn Arg Gln Thr Glu Ser Gln Ile
             420                 425                 430        
 Met Ser Glu Leu Pro Phe Thr Ile Ala Ser Lys Arg Ile Lys Tyr Leu
         435                 440                 445            
 Gly Ile Gln Leu Thr Arg Asp Val Lys Asp Leu Phe Lys Glu Asn Tyr
     450                 455                 460                
 Lys Pro Leu Leu Lys Glu Ile Lys Glu Asp Thr Asn Lys Trp Lys Asn
 465                 470                 475                 480
 Ile Pro Cys Ser Trp Val Gly Arg Ile Asn Ile Met Lys Met Ala Ile
                 485                 490                 495    
 Leu Pro Lys
            



      <210> 2926
      <211> 831
      <212> PRT
      <213> Homo sapiens


      <400> 2926
 Met Thr Leu Ala Leu Ala Tyr Leu Leu Ala Leu Pro Gln Val Leu Asp
   1               5                  10                  15    
 Ala Asn Arg Cys Phe Glu Lys Gln Ser Pro Ser Ala Leu Ser Leu Gln
              20                  25                  30        
 Leu Ala Ala Tyr Tyr Tyr Ser Leu Gln Ile Tyr Ala Arg Leu Ala Pro
          35                  40                  45            
 Cys Phe Arg Asp Lys Cys His Pro Leu Tyr Arg Ala Asp Pro Lys Glu
      50                  55                  60                
 Leu Ile Lys Met Val Thr Arg His Val Thr Arg His Glu His Glu Ala
  65                  70                  75                  80
 Trp Pro Glu Asp Leu Ile Ser Leu Thr Lys Gln Leu His Cys Tyr Asn
                  85                  90                  95    
 Glu Arg Leu Leu Asp Phe Thr Gln Ala Gln Ile Leu Gln Gly Leu Arg
             100                 105                 110        
 Lys Gly Val Asp Val Gln Arg Phe Thr Ala Asp Asp Gln Tyr Lys Arg
         115                 120                 125            
 Glu Thr Ile Leu Gly Leu Ala Glu Thr Leu Glu Glu Ser Val Tyr Ser
     130                 135                 140                
 Ile Ala Ile Ser Leu Ala Gln Arg Tyr Ser Val Ser Arg Trp Glu Val
 145                 150                 155                 160
 Phe Met Thr His Leu Glu Phe Leu Phe Thr Asp Ser Gly Leu Ser Thr
                 165                 170                 175    
 Leu Glu Ile Glu Asn Arg Ala Gln Asp Leu His Leu Phe Glu Thr Leu
             180                 185                 190        
 Lys Thr Asp Pro Glu Ala Phe His Gln His Met Val Lys Tyr Ile Tyr
         195                 200                 205            
 Pro Thr Ile Gly Gly Phe Asp His Glu Arg Leu Gln Tyr Tyr Phe Thr
     210                 215                 220                
 Leu Leu Glu Asn Cys Gly Cys Ala Asp Leu Gly Asn Cys Ala Ile Lys
 225                 230                 235                 240
 Pro Glu Thr His Ile Arg Leu Leu Lys Lys Phe Lys Val Val Ala Ser
                 245                 250                 255    
 Gly Leu Asn Tyr Lys Lys Leu Thr Asp Glu Asn Met Ser Pro Leu Glu
             260                 265                 270        
 Ala Leu Glu Pro Val Leu Ser Ser Gln Asn Ile Leu Ser Ile Ser Lys
         275                 280                 285            
 Leu Val Pro Lys Ile Pro Glu Lys Asp Gly Gln Met Leu Ser Pro Ser
     290                 295                 300                
 Ser Leu Tyr Thr Ile Trp Leu Gln Lys Leu Phe Trp Thr Gly Asp Pro
 305                 310                 315                 320
 His Leu Ile Lys Gln Val Pro Gly Ser Ser Pro Glu Trp Leu His Ala
                 325                 330                 335    
 Tyr Asp Val Cys Met Lys Tyr Phe Asp Arg Leu His Pro Gly Asp Leu
             340                 345                 350        
 Ile Thr Val Val Asp Ala Val Thr Phe Ser Pro Lys Ala Val Thr Lys
         355                 360                 365            
 Leu Ser Val Glu Ala Arg Lys Glu Met Thr Arg Lys Ala Ile Lys Thr
     370                 375                 380                
 Val Lys His Phe Ile Glu Lys Pro Arg Lys Arg Asn Ser Glu Asp Glu
 385                 390                 395                 400
 Ala Gln Glu Ala Lys Asp Ser Lys Val Thr Tyr Ala Asp Thr Leu Asn
                 405                 410                 415    
 His Leu Glu Lys Ser Leu Ala His Leu Glu Thr Leu Ser His Ser Phe
             420                 425                 430        
 Ile Leu Ser Leu Lys Asn Ser Glu Gln Glu Thr Leu Gln Lys Tyr Ser
         435                 440                 445            
 His Leu Tyr Asp Leu Ser Arg Ser Glu Lys Glu Lys Leu His Asp Glu
     450                 455                 460                
 Ala Val Ala Ile Cys Leu Asp Gly Gln Pro Leu Ala Met Ile Gln Gln
 465                 470                 475                 480
 Leu Leu Glu Val Ala Val Gly Pro Leu Asp Ile Ser Pro Lys Asp Ile
                 485                 490                 495    
 Val Gln Ser Ala Ile Met Lys Ile Ile Ser Ala Leu Ser Gly Gly Ser
             500                 505                 510        
 Ala Asp Leu Gly Gly Pro Arg Asp Pro Leu Lys Val Leu Glu Gly Val
         515                 520                 525            
 Val Ala Ala Val His Ala Ser Val Asp Lys Gly Glu Glu Leu Val Ser
     530                 535                 540                
 Pro Glu Asp Leu Leu Glu Trp Leu Arg Pro Phe Cys Ala Asp Asp Ala
 545                 550                 555                 560
 Trp Pro Val Arg Pro Arg Ile His Val Leu Gln Ile Leu Gly Gln Ser
                 565                 570                 575    
 Phe His Leu Thr Glu Glu Asp Ser Lys Leu Leu Val Phe Phe Arg Thr
             580                 585                 590        
 Glu Ala Ile Leu Lys Ala Ser Trp Pro Gln Arg Gln Val Asp Ile Ala
         595                 600                 605            
 Asp Ile Glu Asn Glu Glu Asn Arg Tyr Cys Leu Phe Met Glu Leu Leu
     610                 615                 620                
 Glu Ser Ser His His Glu Ala Glu Phe Gln His Leu Val Leu Leu Leu
 625                 630                 635                 640
 Gln Ala Trp Pro Pro Met Lys Ser Glu Tyr Val Ile Thr Asn Asn Pro
                 645                 650                 655    
 Trp Val Arg Leu Ala Thr Val Met Leu Thr Arg Cys Thr Met Glu Asn
             660                 665                 670        
 Lys Glu Gly Leu Gly Asn Glu Val Leu Lys Met Cys Arg Ser Leu Tyr
         675                 680                 685            
 Asn Thr Lys Gln Met Leu Pro Ala Glu Gly Val Lys Glu Leu Cys Leu
     690                 695                 700                
 Leu Leu Leu Asn Gln Ser Leu Leu Leu Pro Ser Leu Lys Leu Leu Leu
 705                 710                 715                 720
 Glu Ser Arg Asp Glu His Leu His Glu Met Ala Leu Glu Gln Ile Thr
                 725                 730                 735    
 Ala Val Thr Thr Val Asn Asp Ser Asn Cys Asp Gln Glu Leu Leu Ser
             740                 745                 750        
 Leu Leu Leu Asp Ala Lys Leu Leu Val Lys Cys Val Ser Thr Pro Phe
         755                 760                 765            
 Tyr Pro Arg Ile Val Asp His Leu Leu Ala Ser Leu Gln Gln Gly Arg
     770                 775                 780                
 Trp Asp Ala Glu Glu Leu Gly Arg His Leu Arg Glu Ala Gly His Glu
 785                 790                 795                 800
 Ala Glu Ala Gly Ser Leu Leu Leu Ala Val Arg Gly Thr His Gln Ala
                 805                 810                 815    
 Phe Arg Thr Phe Ser Thr Ala Leu Arg Ala Ala Gln His Trp Val
             820                 825                 830    



      <210> 2927
      <211> 488
      <212> PRT
      <213> Homo sapiens


      <400> 2927
 Met Gly Phe Arg His Val Gly Gln Ala Gly Leu Glu Leu Leu Thr Ser
   1               5                  10                  15    
 Gly Leu Gly Leu Val Thr Ala Ser Gly Tyr Cys Thr Ile Ser Trp Gly
              20                  25                  30        
 Ser Pro Cys Thr Cys Ala Phe Gly Asn Gly Pro Ile Asp Gly His Ser
          35                  40                  45            
 Leu Ser Ile Ile Leu Glu Met Gly Leu Cys Thr Met Lys Thr Lys Gln
      50                  55                  60                
 Glu Phe Gln Asp Trp Thr Lys Arg Ser Val Glu Leu Glu Gly Gly Asn
  65                  70                  75                  80
 Ala Ser Ser Glu Leu Gln Ser Phe Gln Gly His His Asn Lys Glu Gly
                  85                  90                  95    
 Leu Arg Asn Cys Arg Ser Gln Glu Glu Pro Glu Glu Met Leu Pro Thr
             100                 105                 110        
 Ile Met Trp Asn Pro Gly Arg Asp Pro Val Glu Asp Ser Glu Ser Gly
         115                 120                 125            
 Val Tyr Met Arg Phe Met Arg Ser His Lys Cys Tyr Asp Ile Val Pro
     130                 135                 140                
 Thr Ser Ser Lys Leu Val Val Phe Asp Thr Thr Leu Gln Val Lys Lys
 145                 150                 155                 160
 Ala Phe Phe Ala Leu Val Ala Asn Gly Val Arg Ala Ala Pro Leu Trp
                 165                 170                 175    
 Glu Ser Lys Lys Gln Ser Phe Val Glu Leu Tyr Leu Gln Glu Thr Phe
             180                 185                 190        
 Lys Pro Leu Val Asn Ile Ser Pro Asp Ala Ser Leu Phe Asp Ala Val
         195                 200                 205            
 Tyr Ser Leu Ile Lys Asn Lys Ile His Arg Leu Pro Val Ile Asp Pro
     210                 215                 220                
 Ile Ser Gly Asn Ala Leu Tyr Ile Leu Thr His Lys Arg Ile Leu Lys
 225                 230                 235                 240
 Phe Leu Gln Leu Phe Met Ser Asp Met Pro Lys Pro Ala Phe Met Lys
                 245                 250                 255    
 Gln Asn Leu Asp Glu Leu Gly Ile Gly Thr Tyr His Asn Ile Ala Phe
             260                 265                 270        
 Ile His Pro Asp Thr Pro Ile Ile Lys Ala Leu Asn Ile Phe Val Glu
         275                 280                 285            
 Arg Arg Ile Ser Ala Leu Pro Val Val Asp Glu Ser Gly Lys Val Val
     290                 295                 300                
 Asp Ile Tyr Ser Lys Phe Asp Val Ile Asn Leu Ala Ala Glu Lys Thr
 305                 310                 315                 320
 Tyr Asn Asn Leu Asp Ile Thr Val Thr Gln Ala Leu Gln His Arg Ser
                 325                 330                 335    
 Gln Tyr Phe Glu Gly Val Val Lys Cys Asn Lys Leu Glu Ile Leu Glu
             340                 345                 350        
 Thr Ile Val Asp Arg Ile Val Arg Ala Glu Val His Arg Leu Val Val
         355                 360                 365            
 Val Asn Glu Ala Asp Ser Ile Val Gly Ile Ile Ser Leu Ser Asp Ile
     370                 375                 380                
 Leu Gln Ala Leu Ile Leu Thr Pro Ala Ala Pro Val Lys Tyr Glu Gln
 385                 390                 395                 400
 Pro Ser Leu Cys Gln Gly His Met Asp Pro Met Trp Glu Gln Thr Ala
                 405                 410                 415    
 Cys Pro Leu Asn Ser Gln Asn Pro Ile Leu Asn Glu Phe Thr Gly Met
             420                 425                 430        
 Glu Gln Val Met Trp His Lys Val Ser Ala Arg Tyr Val Gln Ile Thr
         435                 440                 445            
 Val Pro Tyr Val Arg Ile Gln Gln Tyr Val Thr Ala Ala Ala Gly Ala
     450                 455                 460                
 His Ala Cys Glu Thr Thr Pro Ser Leu Asn Val Glu Val Phe Glu Pro
 465                 470                 475                 480
 Phe Thr Lys Ser Val Cys Phe Leu
                 485            



      <210> 2928
      <211> 196
      <212> PRT
      <213> Homo sapiens

      <220>
      <221> misc_feature
      <222> (1)...(196)
      <223> Xaa = any amino acid or symbol as shown in the table 8 as set forth in Example 2


      <400> 2928
 Lys Phe Tyr Ser Arg Leu Gly Gln His Arg Pro Ala Ala His Cys Tyr
   1               5                  10                  15    
 Ile Pro Thr Tyr Ser Phe Xaa Cys Asn Ile Xaa Glu Lys Met Phe Gly
              20                  25                  30        
 Gly Leu Ile His Leu Thr Glu His Met Arg Ile His Thr Gly Glu Lys
          35                  40                  45            
 Pro Phe Arg Cys Lys Glu Cys Gly Arg Ala Phe Ile Gln Ser Ala Ser
      50                  55                  60                
 Leu Ser Thr His Gln Arg Ile His Thr Gly Glu Lys Pro Phe Glu Cys
  65                  70                  75                  80
 Glu Glu Cys Gly Lys Ala Phe Arg His Arg Ser Ser Leu Asn Gln His
                  85                  90                  95    
 His Arg Thr His Thr Gly Glu Lys Pro Tyr Val Cys Asp Lys Cys Gln
             100                 105                 110        
 Lys Ala Phe Ser Gln Asn Ile Ser Leu Val Gln His Leu Arg Thr His
         115                 120                 125            
 Ser Gly Glu Lys Pro Phe Thr Cys Asn Glu Cys Gly Lys Thr Phe Arg
     130                 135                 140                
 Gln Ile Arg His Leu Ser Glu His Ile Arg Ile His Thr Gly Glu Lys
 145                 150                 155                 160
 Pro Tyr Ala Cys Thr Ala Cys Cys Lys Thr Phe Ser His Arg Ala Tyr
                 165                 170                 175    
 Leu Thr His His Gln Arg Ile His Thr Gly Glu Arg Pro Tyr Lys Cys
             180                 185                 190        
 Lys Glu Trp Gly
         195    



      <210> 2929
      <211> 133
      <212> PRT
      <213> Homo sapiens


      <400> 2929
 Arg Pro Arg Val Arg Pro Arg Val Arg Ser Ile Arg Ala Glu Met Ser
   1               5                  10                  15    
 Arg Ser Val Ala Leu Ala Val Leu Ala Leu Leu Ser Leu Ser Gly Leu
              20                  25                  30        
 Glu Ala Ile Gln Arg Thr Pro Lys Ile Gln Val Tyr Ser Arg His Pro
          35                  40                  45            
 Ala Glu Asn Gly Lys Ser Asn Phe Leu Asn Cys Tyr Val Ser Gly Phe
      50                  55                  60                
 His Pro Ser Asp Ile Glu Val Asp Leu Leu Lys Asn Gly Glu Arg Ile
  65                  70                  75                  80
 Glu Lys Val Glu His Ser Asp Leu Ser Phe Ser Lys Asp Trp Ala Phe
                  85                  90                  95    
 Tyr Leu Leu Tyr Tyr Thr Glu Phe Thr Pro Thr Glu Lys Asp Glu Tyr
             100                 105                 110        
 Ala Cys Arg Val Asn His Val Thr Leu Ser Gln Pro Lys Ile Val Lys
         115                 120                 125            
 Trp Asp Arg Asp Met
     130            



      <210> 2930
      <211> 336
      <212> PRT
      <213> Homo sapiens


      <400> 2930
 Pro Asp Gly His Leu Ala Leu Met Ser Gln Pro Arg Glu Val Arg Glu
   1               5                  10                  15    
 Phe Asn Gly Asp His Phe Leu Leu Glu Arg Ala Ile Arg Ala Asp Phe
              20                  25                  30        
 Ala Leu Val Lys Gly Trp Lys Ala Asp Arg Ala Gly Asn Val Val Phe
          35                  40                  45            
 Arg Arg Ser Ala Arg Asn Phe Asn Val Pro Met Cys Lys Ala Ala Asp
      50                  55                  60                
 Val Thr Ala Val Glu Val Gly Ala Phe Pro Pro Glu Asp Ile His Val
  65                  70                  75                  80
 Pro Asn Ile Tyr Val Gly Arg Val Ile Lys Gly Gln Lys Tyr Glu Lys
                  85                  90                  95    
 Arg Ile Glu Arg Leu Thr Ile Arg Lys Glu Glu Asp Gly Asp Ala Gly
             100                 105                 110        
 Lys Glu Glu Asp Ala Arg Thr Arg Ile Ile Arg Arg Ala Ala Leu Glu
         115                 120                 125            
 Phe Glu Asp Gly Met Tyr Ala Asn Leu Gly Ile Gly Ile Pro Leu Leu
     130                 135                 140                
 Ala Ser Asn Phe Ile Ser Pro Ser Met Thr Val His Leu His Ser Glu
 145                 150                 155                 160
 Asn Gly Ile Leu Gly Leu Gly Pro Phe Pro Thr Glu Asp Glu Val Asp
                 165                 170                 175    
 Ala Asp Leu Ile Asn Ala Gly Lys Gln Thr Val Thr Val Leu Pro Gly
             180                 185                 190        
 Gly Cys Phe Phe Ala Ser Asp Asp Ser Phe Ala Met Ile Arg Gly Gly
         195                 200                 205            
 His Ile Gln Leu Thr Met Leu Gly Ala Met Gln Val Ser Lys Tyr Gly
     210                 215                 220                
 Asp Leu Ala Asn Trp Met Ile Pro Gly Lys Lys Val Lys Gly Met Gly
 225                 230                 235                 240
 Gly Ala Met Asp Leu Val Ser Ser Gln Lys Thr Arg Val Val Val Thr
                 245                 250                 255    
 Met Gln His Cys Thr Lys Asp Asn Thr Pro Lys Ile Met Glu Lys Cys
             260                 265                 270        
 Thr Met Pro Leu Thr Gly Lys Arg Cys Val Asp Arg Ile Ile Thr Glu
         275                 280                 285            
 Lys Pro Val Phe Asp Val His Arg Lys Lys Glu Leu Thr Leu Arg Glu
     290                 295                 300                
 Leu Trp Glu Gly Leu Arg Val Asp Asp Ile Lys Lys Ser Thr Gly Cys
 305                 310                 315                 320
 Ala Phe Ala Val Ser Pro Asn Leu Arg Pro Met Gln Gln Val Ala Pro
                 325                 330                 335    





      <210> 2931
      <211> 340
      <212> PRT
      <213> Homo sapiens

      <220>
      <221> misc_feature
      <222> (1)...(340)
      <223> Xaa = any amino acid or symbol as shown in the table 8 as set forth in Example 2


      <400> 2931
 Arg Pro Leu Pro Ala Leu Gln Leu Trp Ala Arg Asp Leu Pro Leu Ala
   1               5                  10                  15    
 Pro Val Pro Thr Ser Gly Ala Lys Arg Pro Thr Leu Pro Val Trp Ala
              20                  25                  30        
 Val Ala Pro Val Ser Ala Val His Ala Asn Gly Trp Tyr Glu Ala Leu
          35                  40                  45            
 Ala Ala Ser Ser Pro Val Arg Val Ala Glu Glu Val Leu Leu Gly Val
      50                  55                  60                
 His Ala Ala Thr Gly Leu Pro Trp Trp Gly Ser Ile Leu Leu Ser Thr
  65                  70                  75                  80
 Val Ala Leu Arg Gly Ala Val Thr Leu Pro Leu Ala Ala Tyr Gln His
                  85                  90                  95    
 Tyr Ile Leu Ala Lys Leu Gly Gly Lys Leu Gln Pro Glu Ile Lys Thr
             100                 105                 110        
 Ile Ala Arg His Leu Asn Gln Glu Val Ala Val Arg Ala Asn Gln Leu
         115                 120                 125            
 Gly Trp Ser Lys Arg Asp Ala Arg Leu Thr Tyr Leu Lys Asn Met Arg
     130                 135                 140                
 Arg Leu Ile Ser Glu Leu Tyr Val Arg Asp Asn Cys His Pro Phe Lys
 145                 150                 155                 160
 Ala Thr Val Leu Val Trp Ile Gln Leu Pro Met Trp Ile Phe Met Ser
                 165                 170                 175    
 Phe Ala Leu Arg Asn Leu Ser Thr Gly Ala Ala His Ser Glu Gly Phe
             180                 185                 190        
 Ser Val Gln Glu Gln Leu Ala Thr Gly Gly Ile Leu Trp Phe Pro Asp
         195                 200                 205            
 Leu Thr Ala Pro Asp Ser Thr Trp Ile Leu Pro Ile Ser Val Gly Val
     210                 215                 220                
 Ile Asn Leu Leu Ile Val Glu Ile Cys Ala Leu Gln Lys Ile Gly Met
 225                 230                 235                 240
 Ser Arg Phe Gln Thr Tyr Ile Thr Tyr Phe Val Arg Ala Met Ser Val
                 245                 250                 255    
 Leu Met Ile Pro Ile Ala Ala Thr Val Pro Ser Ser Ile Val Leu Tyr
             260                 265                 270        
 Trp Leu Cys Ser Ser Phe Val Gly Leu Ser Gln Asn Leu Leu Leu Arg
         275                 280                 285            
 Ser Pro Gly Phe Arg Gln Leu Cys Arg Ile Pro Ser Thr Lys Ser Asp
     290                 295                 300                
 Ser Glu Thr Pro Tyr Lys Asp Ile Phe Ala Ala Phe Asn Thr Lys Phe
 305                 310                 315                 320
 Ile Ser Arg Lys Xaa His Ile Phe His Asn Phe Glu Thr Val Ala Gly
                 325                 330                 335    
 Val Thr Ile Ile
             340



      <210> 2932
      <211> 157
      <212> PRT
      <213> Homo sapiens


      <400> 2932
 Ala Cys Arg Gly Ala His Val Gln Val Gly Asp Gly Ser Ala Leu Thr
   1               5                  10                  15    
 Tyr Val Glu Asp Gly Thr Ala Cys Gly Pro Thr Met Leu Ser Leu Asp
              20                  25                  30        
 His Leu Cys Leu Pro Ala Leu Ala Phe Asn Phe Ser Thr Cys Thr Asp
          35                  40                  45            
 Ser Gly Glu Arg Arg Ile Cys Ser His His Gly Val Thr Ala Trp Ser
      50                  55                  60                
 Leu Gly Trp Arg Glu Lys Leu Thr Arg Gly Asp Arg Pro Leu Leu Thr
  65                  70                  75                  80
 Ser Pro Gly Pro Ala Leu Pro Ile Gly Cys Ser Asn Glu Gly Lys Cys
                  85                  90                  95    
 Ile Cys Gln Pro Asp Trp Thr Gly Lys Asp Cys Ser Ile His Asn Pro
             100                 105                 110        
 Leu Pro Thr Ser Pro Pro Thr Gly Glu Thr Glu Arg Tyr Lys Gly Pro
         115                 120                 125            
 Ser Gly Thr Asn Ile Ile Ile Asp Ser Ile Ala Gly Ala Val Leu Val
     130                 135                 140                
 Ala Ala Ile Val Leu Asp Glu Thr Gly Trp Gly Tyr Lys
 145                 150                 155        



      <210> 2933
      <211> 901
      <212> PRT
      <213> Homo sapiens


      <400> 2933
 Met Lys Arg Ala Pro Val Ile Pro Lys His Thr Leu Asn Thr Gln Pro
   1               5                  10                  15    
 Val Glu Asp Thr Ser Leu Ser Thr Pro Ala Ala Pro Met Val Asp Ser
              20                  25                  30        
 Leu Ile Ala Arg Val Gly Val Met Ala Arg Gly Asn Ala Ile Thr Leu
          35                  40                  45            
 Pro Val Cys Gly Arg Asp Val Lys Phe Thr Leu Glu Val Leu Arg Gly
      50                  55                  60                
 Asp Ser Val Glu Lys Thr Ser Arg Val Trp Ser Gly Asn Glu Arg Asp
  65                  70                  75                  80
 Gln Glu Leu Leu Thr Glu Asp Ala Leu Asp Asp Leu Ile Pro Ser Phe
                  85                  90                  95    
 Leu Leu Thr Gly Gln Gln Thr Pro Ala Phe Gly Arg Arg Val Ser Gly
             100                 105                 110        
 Val Ile Glu Ile Ala Asp Gly Ser Arg Arg Arg Lys Ala Ala Ala Leu
         115                 120                 125            
 Thr Glu Ser Asp Tyr Arg Val Leu Val Gly Glu Leu Asp Asp Glu Gln
     130                 135                 140                
 Met Ala Ala Leu Ser Arg Leu Gly Asn Asp Tyr Arg Pro Thr Ser Ala
 145                 150                 155                 160
 Tyr Glu Arg Gly Gln Arg Tyr Ala Ser Arg Leu Gln Asn Glu Phe Ala
                 165                 170                 175    
 Gly Asn Ile Ser Ala Leu Ala Asp Ala Asp Phe Ala Asp Phe Gly Thr
             180                 185                 190        
 Thr Ile Lys Gln Asp Phe Arg Leu Leu Gly Gln Thr Ser Val Asp Arg
         195                 200                 205            
 Leu Leu Gln Leu Ser Gln Gly Gln Ala Gly Phe Thr Asp Ser Pro His
     210                 215                 220                
 Tyr Ser Asp His Leu Asn Asp Ser Arg Leu Gly Ala His Glu Gly Leu
 225                 230                 235                 240
 Ser Pro Thr Pro Phe Met Asn Ser Asn Leu Met Val Asp Ser Cys Ser
                 245                 250                 255    
 Lys Leu Glu Gln His Ser Thr Leu Ser Arg Ala Ile Leu Leu Ile Tyr
             260                 265                 270        
 Lys Gly Phe Cys Arg Phe Arg Asn His His Gln Thr Gly Phe Ser Pro
         275                 280                 285            
 Ala Gly Ala Asn Gln Arg Gly Pro Leu Ala Ala Thr Leu Ser Gly Pro
     290                 295                 300                
 Gly Gly Glu Gly Gln Ser Ala Val Ala Arg Leu Thr Gly Glu Lys Lys
 305                 310                 315                 320
 Asn His Pro Gly Ala Gln Tyr Ala Asn Arg Leu Ser Pro Arg Val Gly
                 325                 330                 335    
 Arg Phe Ile Asn Ala Ala Gly Thr Thr Gly Phe Pro Thr Gly Lys Arg
             340                 345                 350        
 Ala Val Ser Ala Thr Gln Leu Ile Gln Ala Pro Cys Met Lys Ser Asn
         355                 360                 365            
 Asn Ala Leu Ile Val Ile Leu Gly His Arg His Leu Gly Cys Gly Ile
     370                 375                 380                
 Gly Leu Val Met Pro Val Arg Arg Ala Phe Leu Arg Asp Ile Val His
 385                 390                 395                 400
 Ser Asp Ser Ile Ala Ser His Tyr Gly Val Leu Leu Ala Leu Tyr Ala
                 405                 410                 415    
 Leu Met Gln Phe Leu Cys Ala Pro Val Leu Gly Ala Leu Ser Asp Arg
             420                 425                 430        
 Phe Gly Arg Arg Pro Val Leu Leu Ala Ser Leu Leu Gly Ala Thr Ile
         435                 440                 445            
 Asp Tyr Ala Ile Met Ala Thr Thr Pro Val Leu Trp Ile Tyr Pro Leu
     450                 455                 460                
 Leu Thr Val Ser Cys Pro Cys Ser Arg Met Leu Phe Leu Thr Thr Asp
 465                 470                 475                 480
 Val Leu Leu Pro Leu Met Phe Ile Lys Lys Leu Gly Ala Asn Val Ala
                 485                 490                 495    
 Phe Leu Ser Ser Lys Gln Ala Ser Val Cys His Val Ala Cys Asp Asn
             500                 505                 510        
 Pro Thr Val Ala Phe Gly Leu Arg His Cys Glu Val Arg Lys His Lys
         515                 520                 525            
 Ala Ile Val Gln Asn Leu Glu Ser Pro Glu Asn Gly Gly Ser Glu Ser
     530                 535                 540                
 Gly Thr Tyr Ser Ser Pro Pro Leu Glu Thr Thr Val Pro Pro Pro Ala
 545                 550                 555                 560
 Pro Gly Leu Pro Arg Ala Pro Gly Gln Gly Phe Phe Val Val His Arg
                 565                 570                 575    
 Leu Gly Tyr Gly Pro Gly Leu Cys Lys Gln Lys His Thr Pro Ser Leu
             580                 585                 590        
 Met Ser Val Glu Pro Glu Gln Phe Cys Leu His Leu Val Ser Lys Ala
         595                 600                 605            
 Leu Asp Gly Glu Tyr Lys Leu Gln Arg Leu Lys Arg Ser Glu Leu Asn
     610                 615                 620                
 Trp Thr Leu Trp Gln Lys Asn Lys Asn His Phe Val His Phe Ala Ile
 625                 630                 635                 640
 Pro Val Tyr Leu Val Phe Gln Asp Leu Ala Leu Asn Gly Leu Arg Ala
                 645                 650                 655    
 Leu Leu Val Gln Gly Asn Asp Pro Gln Gly Ser Ala Ser Met Tyr His
             660                 665                 670        
 Gly Trp Val Pro Asp Phe His Ile His Ala Glu Asp Thr Leu Leu Pro
         675                 680                 685            
 Phe Tyr Pro Gly Glu Lys Asp Asp Val Thr Tyr Ala Ile Lys Pro Thr
     690                 695                 700                
 Cys Trp Pro Gly Leu Asp Ile Ile Pro Ser Cys Leu Ala Leu His Arg
 705                 710                 715                 720
 Ile Glu Thr Glu Leu Leu Gly Lys Phe Asp Glu Gly Lys Leu Pro Thr
                 725                 730                 735    
 His Pro His Leu Met Leu Arg Leu Ala Ile Glu Thr Val Ala His Asp
             740                 745                 750        
 Tyr Asp Val Ile Val Ile Asp Ser Ala Pro Asn Leu Gly Ile Gly Thr
         755                 760                 765            
 Ile Asn Val Ser Leu Glu Glu Val Cys Asp Leu Leu His Ala Ala Pro
     770                 775                 780                
 Phe Gln Asn Ile Leu Pro Arg Val His Val Lys Val Lys Asn Trp Thr
 785                 790                 795                 800
 Gly Arg Met Asp Gln Leu Phe Ser Asp Ser Asp Leu Leu Leu Arg Gly
                 805                 810                 815    
 Arg Lys Gln Val Arg Asp Phe Ala Asp Phe Gly Thr Thr Ile Lys Gln
             820                 825                 830        
 Asp Phe Arg Leu Leu Gly Gln Thr Ser Val Asp Arg Leu Leu Gln Leu
         835                 840                 845            
 Ser Gln Gly Gln Ala Val Lys Gly Asn Gln Leu Leu Pro Val Ser Leu
     850                 855                 860                
 Val Lys Arg Lys Thr Thr Leu Ala Pro Asn Thr Gln Thr Ala Ser Pro
 865                 870                 875                 880
 Arg Ala Leu Ala Asp Ser Leu Met Gln Leu Ala Arg Gln Val Ser Arg
                 885                 890                 895    
 Leu Glu Ser Gly Gln
             900    



      <210> 2934
      <211> 339
      <212> PRT
      <213> Homo sapiens


      <400> 2934
 Ala Ala Ala Arg Ala Pro Ala Ser Leu Pro Pro Arg Val Pro Arg Cys
   1               5                  10                  15    
 Pro Pro Arg Ala Gly Ala Met Arg Leu Gly Pro Arg Thr Ala Ala Leu
              20                  25                  30        
 Gly Leu Leu Leu Leu Cys Ala Ala Ala Ala Gly Ala Gly Lys Ala Glu
          35                  40                  45            
 Glu Leu His Tyr Pro Leu Gly Glu Arg Arg Ser Asp Tyr Asp Arg Glu
      50                  55                  60                
 Ala Leu Leu Gly Val Gln Glu Asp Val Asp Glu Tyr Val Lys Leu Gly
  65                  70                  75                  80
 His Glu Glu Gln Gln Lys Arg Leu Gln Ala Ile Ile Lys Lys Ile Asp
                  85                  90                  95    
 Leu Asp Ser Asp Gly Phe Leu Thr Glu Ser Glu Leu Ser Ser Trp Ile
             100                 105                 110        
 Gln Met Ser Phe Lys His Tyr Ala Met Gln Glu Ala Lys Gln Gln Phe
         115                 120                 125            
 Val Glu Tyr Asp Lys Asn Ser Asp Asp Thr Val Thr Trp Asp Glu Tyr
     130                 135                 140                
 Asn Ile Gln Met Tyr Asp Arg Val Ile Asp Phe Asp Glu Asn Thr Ala
 145                 150                 155                 160
 Leu Asp Asp Ala Glu Glu Glu Ser Phe Arg Lys Leu His Leu Lys Asp
                 165                 170                 175    
 Lys Lys Arg Phe Glu Lys Ala Asn Gln Asp Ser Gly Pro Gly Leu Ser
             180                 185                 190        
 Leu Glu Glu Phe Ile Ala Phe Glu His Pro Glu Glu Val Asp Tyr Met
         195                 200                 205            
 Thr Glu Phe Val Ile Gln Glu Ala Leu Glu Glu His Asp Lys Asn Gly
     210                 215                 220                
 Asp Gly Phe Val Ser Leu Glu Glu Phe Leu Gly Asp Tyr Arg Trp Asp
 225                 230                 235                 240
 Pro Thr Ala Asn Glu Asp Pro Glu Trp Ile Leu Val Glu Lys Asp Arg
                 245                 250                 255    
 Phe Val Asn Asp Tyr Asp Lys Asp Asn Asp Gly Arg Leu Asp Pro Gln
             260                 265                 270        
 Glu Leu Leu Pro Trp Val Val Pro Asn Asn Gln Gly Ile Ala Gln Glu
         275                 280                 285            
 Glu Ala Leu His Leu Ile Asp Glu Met Asp Leu Asn Gly Asp Lys Lys
     290                 295                 300                
 Leu Ser Glu Glu Glu Ile Leu Glu Asn Pro Asp Leu Phe Leu Thr Ser
 305                 310                 315                 320
 Glu Ala Thr Asp Tyr Gly Arg Gln Leu His Asp Asp Tyr Phe Tyr His
                 325                 330                 335    
 Asp Glu Leu
            



      <210> 2935
      <211> 440
      <212> PRT
      <213> Homo sapiens


      <400> 2935
 Arg Ala Pro Ala Arg Gln Gly Pro Gly Pro Ala Arg Leu Pro Gly Met
   1               5                  10                  15    
 Val Ser Lys Ala Leu Leu Arg Leu Val Ser Ala Val Asn Arg Arg Arg
              20                  25                  30        
 Met Lys Leu Leu Leu Gly Ile Ala Leu Leu Ala Tyr Val Ala Ser Val
          35                  40                  45            
 Trp Gly Asn Phe Val Asn Met Ser Phe Leu Leu Asn Arg Ser Ile Gln
      50                  55                  60                
 Glu Asn Gly Glu Leu Lys Ile Glu Ser Lys Ile Glu Glu Met Val Glu
  65                  70                  75                  80
 Pro Leu Arg Glu Lys Ile Arg Asp Leu Glu Lys Ser Phe Thr Gln Lys
                  85                  90                  95    
 Tyr Pro Pro Val Lys Phe Leu Ser Glu Lys Asp Arg Lys Arg Ile Leu
             100                 105                 110        
 Ile Thr Gly Gly Ala Gly Phe Val Gly Ser His Leu Thr Asp Lys Leu
         115                 120                 125            
 Met Met Asp Gly His Glu Val Thr Val Val Asp Asn Phe Phe Thr Gly
     130                 135                 140                
 Arg Lys Arg Asn Val Glu His Trp Ile Gly His Glu Asn Phe Glu Leu
 145                 150                 155                 160
 Ile Asn His Asp Val Val Glu Pro Leu Tyr Ile Glu Val Asp Gln Ile
                 165                 170                 175    
 Tyr His Leu Ala Ser Pro Ala Ser Pro Pro Asn Tyr Met Tyr Asn Pro
             180                 185                 190        
 Ile Lys Thr Leu Lys Thr Asn Thr Ile Gly Thr Leu Asn Met Leu Gly
         195                 200                 205            
 Leu Ala Lys Arg Val Gly Ala Arg Leu Leu Leu Ala Ser Thr Ser Glu
     210                 215                 220                
 Val Tyr Gly Asp Pro Glu Val His Pro Gln Ser Glu Asp Tyr Trp Gly
 225                 230                 235                 240
 His Val Asn Pro Ile Gly Pro Arg Ala Cys Tyr Asp Glu Gly Lys Arg
                 245                 250                 255    
 Val Ala Glu Thr Met Cys Tyr Ala Tyr Met Lys Gln Glu Gly Val Glu
             260                 265                 270        
 Val Arg Val Ala Arg Ile Phe Asn Thr Phe Gly Pro Arg Met His Met
         275                 280                 285            
 Asn Asp Gly Arg Val Val Ser Asn Phe Ile Leu Gln Ala Leu Gln Gly
     290                 295                 300                
 Glu Pro Leu Thr Val Tyr Gly Ser Gly Ser Gln Thr Arg Ala Phe Gln
 305                 310                 315                 320
 Tyr Val Ser Asp Leu Val Asn Gly Leu Val Ala Leu Met Asn Ser Asn
                 325                 330                 335    
 Val Ser Ser Pro Val Asn Leu Gly Asn Pro Glu Glu His Thr Ile Leu
             340                 345                 350        
 Glu Phe Ala Gln Leu Ile Lys Asn Leu Val Gly Ser Gly Ser Glu Ile
         355                 360                 365            
 Gln Phe Leu Ser Glu Ala Gln Asp Asp Pro Gln Lys Arg Lys Pro Asp
     370                 375                 380                
 Ile Lys Lys Ala Lys Leu Met Leu Gly Trp Glu Pro Val Val Pro Leu
 385                 390                 395                 400
 Glu Glu Gly Leu Asn Lys Ala Ile His Tyr Phe Arg Lys Glu Leu Glu
                 405                 410                 415    
 Tyr Gln Ala Asn Asn Gln Tyr Ile Pro Lys Pro Lys Pro Ala Arg Ile
             420                 425                 430        
 Lys Lys Gly Arg Thr Arg His Ser
         435                 440



      <210> 2936
      <211> 325
      <212> PRT
      <213> Homo sapiens


      <400> 2936
 Leu Pro Thr Pro Ser Arg Val Leu Arg Ala Met Ala Asp Thr Ile Phe
   1               5                  10                  15    
 Gly Ser Gly Asn Asp Gln Trp Val Cys Pro Asn Asp Arg Gln Leu Ala
              20                  25                  30        
 Leu Arg Ala Lys Leu Gln Thr Gly Trp Ser Val His Thr Tyr Gln Thr
          35                  40                  45            
 Glu Lys Gln Arg Arg Lys Gln His Leu Ser Pro Ala Glu Val Glu Ala
      50                  55                  60                
 Ile Leu Gln Val Ile Gln Arg Ala Glu Arg Leu Asp Val Leu Glu Gln
  65                  70                  75                  80
 Gln Arg Ile Gly Arg Leu Val Glu Arg Leu Glu Thr Met Arg Arg Asn
                  85                  90                  95    
 Val Met Gly Asn Gly Leu Ser Gln Cys Leu Leu Cys Gly Glu Val Leu
             100                 105                 110        
 Gly Phe Leu Gly Ser Ser Ser Val Phe Cys Lys Asp Cys Arg Lys Lys
         115                 120                 125            
 Val Cys Thr Lys Cys Gly Ile Glu Ala Ser Pro Gly Gln Lys Arg Pro
     130                 135                 140                
 Leu Trp Leu Cys Lys Ile Cys Ser Glu Gln Arg Glu Val Trp Lys Arg
 145                 150                 155                 160
 Ser Gly Ala Trp Phe Tyr Lys Gly Leu Pro Lys Tyr Ile Leu Pro Leu
                 165                 170                 175    
 Lys Thr Pro Gly Arg Ala Asp Asp Pro His Phe Arg Pro Leu Pro Thr
             180                 185                 190        
 Glu Pro Ala Glu Arg Glu Pro Arg Ser Ser Glu Thr Ser Arg Ile Tyr
         195                 200                 205            
 Thr Trp Ala Arg Gly Arg Val Val Ser Ser Asp Ser Asp Ser Asp Ser
     210                 215                 220                
 Asp Leu Ser Ser Ser Ser Leu Glu Asp Arg Leu Pro Ser Thr Gly Val
 225                 230                 235                 240
 Arg Asp Arg Lys Gly Asp Lys Pro Trp Lys Glu Ser Gly Gly Ser Val
                 245                 250                 255    
 Glu Ala Pro Arg Met Gly Phe Thr His Pro Pro Gly His Leu Ser Gly
             260                 265                 270        
 Cys Gln Ser Ser Leu Ala Ser Gly Glu Thr Gly Thr Gly Ser Ala Asp
         275                 280                 285            
 Pro Pro Gly Gly Pro Arg Pro Gly Leu Thr Arg Arg Ala Pro Val Lys
     290                 295                 300                
 Asp Thr Pro Gly Arg Ala Pro Ala Ala Asp Ala Ala Pro Ala Gly Pro
 305                 310                 315                 320
 Ser Ser Cys Leu Gly
                 325



      <210> 2937
      <211> 391
      <212> PRT
      <213> Homo sapiens


      <400> 2937
 Lys Val Cys Gln Thr Val Val Asp Val Gly Glu Lys Thr Ser Glu Phe
   1               5                  10                  15    
 Lys Ala Lys Gly Tyr Leu Ala Leu Gly Leu Thr Tyr Ser Leu Gln Ala
              20                  25                  30        
 Thr Asp Ala Ser Leu Arg Gly Met Gln Glu Val Leu Gln Arg Lys Ala
          35                  40                  45            
 Leu Leu Ala Phe Gln Arg Ala His Ser Leu Ser Pro Thr Asp His Gln
      50                  55                  60                
 Ala Ala Phe Tyr Leu Ala Leu Gln Leu Ala Ile Ser Arg Gln Ile Pro
  65                  70                  75                  80
 Glu Ala Leu Gly Tyr Val Arg Gln Ala Leu Gln Leu Gln Gly Asp Asp
                  85                  90                  95    
 Ala Asn Ser Leu His Leu Leu Ala Leu Leu Leu Ser Ala Gln Lys His
             100                 105                 110        
 Tyr His Asp Ala Leu Asn Ile Ile Asp Met Ala Leu Ser Glu Tyr Pro
         115                 120                 125            
 Glu Asn Phe Ile Leu Leu Phe Ser Lys Val Lys Leu Gln Ser Leu Cys
     130                 135                 140                
 Arg Gly Pro Asp Glu Ala Leu Leu Thr Cys Lys His Met Leu Gln Ile
 145                 150                 155                 160
 Trp Lys Ser Cys Tyr Asn Leu Thr Asn Pro Ser Asp Ser Gly Arg Gly
                 165                 170                 175    
 Ser Ser Leu Leu Asp Arg Thr Ile Ala Asp Arg Arg Gln Leu Asn Thr
             180                 185                 190        
 Ile Thr Leu Pro Asp Phe Ser Asp Pro Glu Thr Gly Ser Val His Ala
         195                 200                 205            
 Thr Ser Val Ala Ala Ser Arg Val Glu Gln Ala Leu Ser Glu Val Ala
     210                 215                 220                
 Ser Ser Leu Gln Ser Ser Ala Pro Lys Gln Gly Pro Leu His Pro Trp
 225                 230                 235                 240
 Met Thr Leu Ala Gln Ile Trp Leu His Ala Ala Glu Val Tyr Ile Gly
                 245                 250                 255    
 Ile Gly Lys Pro Ala Glu Ala Thr Ala Cys Thr Gln Glu Ala Ala Asn
             260                 265                 270        
 Leu Phe Pro Met Ser His Asn Val Leu Tyr Met Arg Gly Gln Ile Ala
         275                 280                 285            
 Glu Leu Arg Gly Ser Met Asp Glu Ala Arg Arg Gly Tyr Glu Glu Ala
     290                 295                 300                
 Leu Ala Ile Ser Pro Thr His Val Lys Ser Met Gln Arg Leu Ala Leu
 305                 310                 315                 320
 Ile Leu His Gln Leu Gly Arg Tyr Ser Leu Ala Glu Lys Ile Leu Arg
                 325                 330                 335    
 Asp Ala Val Gln Val Asn Ser Thr Ala His Glu Val Trp Asn Gly Leu
             340                 345                 350        
 Gly Glu Val Leu Gln Ala Gln Gly Asn Asp Ala Ala Ala Thr Glu Cys
         355                 360                 365            
 Phe Leu Thr Ala Leu Glu Leu Glu Ala Ser Ser Pro Ala Val Pro Phe
     370                 375                 380                
 Thr Ile Ile Pro Arg Val Leu
 385                 390    



      <210> 2938
      <211> 1357
      <212> PRT
      <213> Homo sapiens

      <220>
      <221> misc_feature
      <222> (1)...(1357)
      <223> Xaa = any amino acid or symbol as shown in the table 8 as set forth in Example 2


      <400> 2938
 Leu Leu Leu Gly Arg Ala Asn Ser Pro Pro Tyr Asn Ser Val Val Arg
   1               5                  10                  15    
 Thr Leu Pro Pro Ala Thr Leu Leu Leu Arg Arg Ala Gly Trp Glu Ser
              20                  25                  30        
 Phe Trp Ser Cys Gln Ser Arg Ser Pro Trp Pro Pro Arg Pro Glu Val
          35                  40                  45            
 Arg Ala Pro Ala Lys Gly Pro Arg Gly Val Ala Gly Ala Ala Gly Ala
      50                  55                  60                
 Cys Ser Ala Gly Ala Arg Leu Gly Asp Ala Ala Gly Gly Asp Pro Ala
  65                  70                  75                  80
 Ser Gly Gln Ala Ala Arg Gly Cys Gly Ala Arg Ala Pro Arg Gly Leu
                  85                  90                  95    
 Gly Arg Thr Ala Arg Ala Arg Asp Thr Ala Met Glu Asp Ala Gly Ala
             100                 105                 110        
 Ala Gly Pro Gly Pro Glu Pro Glu Pro Glu Pro Glu Pro Glu Pro Glu
         115                 120                 125            
 Pro Ala Pro Glu Pro Glu Pro Glu Pro Lys Pro Gly Ala Gly Thr Ser
     130                 135                 140                
 Glu Ala Phe Ser Arg Leu Trp Thr Asp Val Met Gly Ile Leu Asp Gly
 145                 150                 155                 160
 Ser Leu Gly Asn Ile Asp Asp Leu Ala Gln Gln Tyr Ala Asp Tyr Tyr
                 165                 170                 175    
 Asn Thr Cys Phe Ser Asp Val Cys Glu Arg Met Glu Glu Leu Arg Lys
             180                 185                 190        
 Arg Arg Val Ser Gln Asp Leu Glu Val Glu Lys Pro Asp Ala Ser Pro
         195                 200                 205            
 Thr Ser Leu Gln Leu Arg Ser Gln Ile Glu Glu Ser Leu Gly Phe Cys
     210                 215                 220                
 Ser Ala Val Ser Thr Pro Glu Val Glu Arg Lys Asn Pro Leu His Lys
 225                 230                 235                 240
 Ser Asn Ser Glu Asp Ser Ser Val Gly Lys Gly Asp Trp Lys Lys Lys
                 245                 250                 255    
 Asn Lys Tyr Phe Trp Gln Asn Phe Arg Lys Asn Gln Lys Gly Ile Met
             260                 265                 270        
 Arg Gln Thr Ser Lys Gly Glu Asp Val Gly Tyr Val Ala Ser Glu Ile
         275                 280                 285            
 Thr Met Ser Asp Glu Glu Arg Ile Gln Leu Met Met Met Val Lys Glu
     290                 295                 300                
 Lys Met Ile Thr Ile Glu Glu Ala Leu Ala Arg Leu Lys Glu Tyr Glu
 305                 310                 315                 320
 Ala Gln His Arg Gln Ser Ala Ala Leu Asp Pro Ala Asp Trp Pro Asp
                 325                 330                 335    
 Gly Ser Tyr Pro Thr Phe Asp Gly Ser Ser Asn Cys Asn Ser Arg Glu
             340                 345                 350        
 Gln Ser Asp Asp Glu Thr Glu Glu Ser Val Lys Phe Lys Arg Leu His
         355                 360                 365            
 Lys Leu Val Asn Ser Thr Arg Arg Val Arg Lys Lys Leu Ile Arg Val
     370                 375                 380                
 Glu Glu Met Lys Lys Pro Ser Thr Glu Gly Gly Glu Glu His Val Phe
 385                 390                 395                 400
 Glu Asn Ser Pro Val Leu Asp Glu Arg Ser Ala Leu Tyr Ser Gly Val
                 405                 410                 415    
 His Lys Lys Pro Leu Phe Phe Asp Gly Ser Pro Glu Lys Pro Pro Glu
             420                 425                 430        
 Asp Asp Ser Asp Ser Leu Thr Thr Ser Pro Ser Ser Ser Ser Leu Asp
         435                 440                 445            
 Thr Trp Gly Ala Gly Arg Lys Leu Val Lys Thr Phe Ser Lys Gly Glu
     450                 455                 460                
 Ser Arg Gly Leu Ile Lys Pro Pro Lys Lys Met Gly Thr Phe Phe Ser
 465                 470                 475                 480
 Tyr Pro Glu Glu Glu Lys Ala Gln Lys Val Ser Arg Ser Leu Thr Glu
                 485                 490                 495    
 Gly Glu Met Lys Lys Gly Leu Gly Ser Leu Ser His Gly Arg Thr Cys
             500                 505                 510        
 Ser Phe Gly Gly Phe Asp Leu Thr Asn Arg Ser Leu His Val Gly Ser
         515                 520                 525            
 Asn Asn Ser Asp Pro Met Gly Lys Glu Gly Asp Phe Val Tyr Lys Glu
     530                 535                 540                
 Val Ile Lys Ser Pro Thr Ala Ser Arg Ile Ser Leu Gly Lys Lys Val
 545                 550                 555                 560
 Lys Ser Val Lys Glu Thr Met Arg Lys Arg Met Ser Lys Lys Tyr Ser
                 565                 570                 575    
 Ser Ser Val Ser Glu Gln Asp Ser Gly Leu Asp Gly Met Pro Gly Ser
             580                 585                 590        
 Pro Pro Pro Ser Gln Pro Asp Pro Glu His Leu Asp Lys Pro Lys Leu
         595                 600                 605            
 Lys Ala Gly Gly Ser Val Glu Ser Leu Arg Ser Ser Leu Ser Gly Gln
     610                 615                 620                
 Ser Ser Met Ser Gly Gln Thr Val Ser Thr Thr Asp Ser Ser Thr Ser
 625                 630                 635                 640
 Asn Arg Glu Ser Val Lys Ser Glu Asp Gly Asp Asp Glu Glu Pro Pro
                 645                 650                 655    
 Tyr Arg Gly Pro Phe Cys Gly Arg Ala Arg Val His Thr Asp Phe Thr
             660                 665                 670        
 Pro Ser Pro Tyr Asp Thr Asp Ser Leu Lys Leu Lys Lys Gly Asp Ile
         675                 680                 685            
 Ile Asp Ile Ile Ser Lys Pro Pro Met Gly Thr Trp Met Gly Leu Leu
     690                 695                 700                
 Asn Asn Lys Val Gly Thr Phe Asn Phe Ile Tyr Val Asp Val Leu Ser
 705                 710                 715                 720
 Glu Asp Glu Glu Lys Pro Lys Arg Pro Thr Arg Arg Arg Arg Lys Gly
                 725                 730                 735    
 Arg Pro Pro Gln Pro Lys Ser Val Glu Asp Leu Leu Asp Arg Ile Asn
             740                 745                 750        
 Leu Lys Glu His Met Pro Thr Phe Leu Phe Asn Gly Tyr Glu Asp Leu
         755                 760                 765            
 Asp Thr Phe Lys Leu Leu Glu Glu Glu Asp Leu Asp Glu Leu Asn Ile
     770                 775                 780                
 Arg Asp Pro Glu His Arg Ala Asp Leu Leu Thr Ala Val Glu Leu Leu
 785                 790                 795                 800
 Gln Glu Tyr Asp Ser Asn Ser Asp Gln Ser Gly Ser Gln Glu Lys Leu
                 805                 810                 815    
 Leu Val Asp Ser Gln Gly Leu Ser Gly Cys Ser Pro Arg Asp Ser Xaa
             820                 825                 830        
 Cys Tyr Glu Ser Ser Glu Asn Leu Glu Asn Gly Lys Thr Arg Lys Ala
         835                 840                 845            
 Ser Leu Leu Ser Ala Lys Ser Ser Thr Glu Pro Ser Leu Lys Ala Phe
     850                 855                 860                
 Ser Arg Asn Gln Leu Gly Asn Tyr Pro Thr Leu Pro Leu Met Lys Ser
 865                 870                 875                 880
 Gly Asp Ala Leu Lys Gln Gly Gln Glu Glu Gly Arg Leu Gly Gly Gly
                 885                 890                 895    
 Leu Ala Pro Asp Thr Ser Lys Ser Cys Asp Pro Pro Gly Cys Xaa Leu
             900                 905                 910        
 Val Leu Asn Lys Asn Arg Arg Lys Pro Pro Ser Phe Pro Ser Cys Arg
         915                 920                 925            
 Ser Cys Glu Thr Leu Glu Gly Pro Gln Thr Val Asp Thr Trp Pro Arg
     930                 935                 940                
 Ser His Ser Leu Asp Asp Leu Gln Val Glu Pro Gly Ala Glu Gln Asp
 945                 950                 955                 960
 Val Pro Thr Glu Val Thr Glu Pro Pro Pro Gln Ile Val Pro Glu Val
                 965                 970                 975    
 Pro Gln Lys Thr Thr Ala Ser Ser Thr Lys Ala Gln Pro Leu Glu Gln
             980                 985                 990        
 Asp Ser Ala Val Asp Asn Ala Leu Leu Leu Thr Gln Ser Lys Arg Phe
         995                1000                1005            
 Ser Glu Pro Gln Lys Leu Thr Thr Lys Lys Leu Glu Gly Ser Ile Ala
    1010                1015                1020                
 Ala Ser Gly Arg Gly Leu Ser Pro Pro Gln Cys Leu Pro Arg Asn Tyr
1025                1030                1035                1040
 Asp Ala Gln Pro Pro Gly Ala Lys His Gly Leu Ala Arg Thr Pro Leu
                1045                1050                1055    
 Glu Gly His Arg Lys Gly His Glu Phe Glu Gly Thr His His Pro Leu
            1060                1065                1070        
 Gly Thr Lys Glu Gly Val Asp Ala Glu Gln Arg Met Gln Pro Lys Ile
        1075                1080                1085            
 Pro Ser Gln Pro Pro Pro Val Pro Ala Lys Lys Ser Arg Glu Arg Leu
    1090                1095                1100                
 Ala Asn Gly Leu His Pro Val Pro Met Gly Pro Ser Gly Ala Leu Pro
1105                1110                1115                1120
 Ser Pro Asp Ala Pro Cys Leu Pro Val Lys Arg Gly Ser Pro Ala Ser
                1125                1130                1135    
 Pro Thr Ser Pro Ser Asp Cys Pro Pro Ala Leu Ala Pro Arg Pro Leu
            1140                1145                1150        
 Ser Gly Gln Ala Leu Gly Ser Pro Pro Ser Thr Arg Pro Pro Pro Trp
        1155                1160                1165            
 Leu Ser Glu Leu Pro Glu Asn Thr Ser Leu Gln Glu His Gly Val Lys
    1170                1175                1180                
 Leu Gly Pro Ala Leu Thr Arg Lys Val Ser Cys Ala Arg Gly Val Asp
1185                1190                1195                1200
 Leu Glu Thr Leu Thr Glu Asn Lys Leu His Ala Glu Gly Ile Arg Ser
                1205                1210                1215    
 Ser Arg Arg Glu Pro Tyr Ser Xaa Leu Arg His Gly Arg Cys Gly Ile
            1220                1225                1230        
 Pro Glu Ala Leu Val Gln Arg Tyr Ala Glu Asp Leu Asp Gln Pro Glu
        1235                1240                1245            
 Arg Asp Val Ala Ala Asn Met Asp Gln Ile Arg Val Lys Gln Leu Arg
    1250                1255                1260                
 Lys Gln His Arg Met Ala Ile Pro Ser Gly Gly Leu Thr Glu Ile Cys
1265                1270                1275                1280
 Arg Lys Pro Val Ser Pro Gly Cys Ile Ser Ser Val Ser Asp Trp Leu
                1285                1290                1295    
 Ile Ser Ile Gly Leu Pro Met Tyr Ala Gly Thr Leu Ser Thr Ala Gly
            1300                1305                1310        
 Phe Ser Thr Leu Ser Gln Val Pro Ser Leu Ser His Thr Cys Leu Gln
        1315                1320                1325            
 Glu Ala Gly Ile Thr Glu Glu Arg His Ile Arg Lys Leu Leu Ser Ala
    1330                1335                1340                
 Ala Arg Leu Phe Lys Leu Pro Pro Gly Pro Glu Ala Met
1345                1350                1355        



      <210> 2939
      <211> 144
      <212> PRT
      <213> Homo sapiens

      <220>
      <221> misc_feature
      <222> (1)...(144)
      <223> Xaa = any amino acid or symbol as shown in the table 8 as set forth in Example 2


      <400> 2939
 His Arg Ser Gly Gly Gly Gly Arg Ile Arg Ala Pro Leu Gly Leu Thr
   1               5                  10                  15    
 Pro Glu Pro Ser Ser His Pro Gly Glu Gly Leu Pro Pro Arg Leu Thr
              20                  25                  30        
 Ala Glu Trp Gly Ala Pro Gly Xaa Thr Lys Ser Cys Ala His Pro Ser
          35                  40                  45            
 Val Gln Thr Pro Gln Gly Asn Ser Gly Leu Xaa Lys Pro Ser Tyr Pro
      50                  55                  60                
 Pro Ala Leu Arg Ser Gly Pro His Ser Thr Gly Ala His Arg Pro Gly
  65                  70                  75                  80
 Ala Arg Arg Ser Ala Ile Thr Gly Pro Pro Asn Ser Pro Arg Lys Val
                  85                  90                  95    
 His Pro Pro Gly Leu Pro Val Pro Gln Val Pro Arg Ala Arg Pro Trp
             100                 105                 110        
 Ala Ser Ala Ala Ser Pro Trp Tyr Arg Thr Pro Ile Val Pro Asp Thr
         115                 120                 125            
 Trp Arg Leu Arg Pro Pro Pro Pro Thr Lys Ser Ser Thr Arg Glu Phe
     130                 135                 140                





      <210> 2940
      <211> 988
      <212> PRT
      <213> Homo sapiens


      <400> 2940
 Ala Lys Asp Gly Thr Lys Asp Gly Leu Glu Arg Thr Arg Ala Ala Val
   1               5                  10                  15    
 Lys Arg Gly Arg Ser Phe Ile Arg Thr Lys Ser Leu Ile Ala Gln Asp
              20                  25                  30        
 His Arg Ser Ser Leu Glu Glu Glu Gln Asn Phe Phe Ile Asp Val Asp
          35                  40                  45            
 Cys Lys His Pro Glu Ala Ile Leu Thr Pro Met Pro Glu Gly Leu Ser
      50                  55                  60                
 Gln Gln Gln Val Val Arg Arg Tyr Ile Leu Gly Ser Val Val Asp Ser
  65                  70                  75                  80
 Glu Lys Asn Tyr Val Asp Ala Leu Lys Arg Ile Leu Glu Gln Tyr Glu
                  85                  90                  95    
 Lys Pro Leu Ser Glu Met Glu Pro Lys Val Leu Ser Glu Arg Lys Leu
             100                 105                 110        
 Lys Thr Val Phe Tyr Arg Val Lys Glu Ile Leu Gln Cys His Ser Leu
         115                 120                 125            
 Phe Gln Ile Ala Leu Ala Ser Arg Val Ser Glu Trp Asp Ser Val Glu
     130                 135                 140                
 Met Ile Gly Asp Val Phe Val Ala Ser Phe Ser Lys Ser Met Val Leu
 145                 150                 155                 160
 Asp Ala Tyr Ser Glu Tyr Val Asn Asn Phe Ser Thr Ala Val Ala Val
                 165                 170                 175    
 Leu Lys Lys Thr Cys Ala Thr Lys Pro Ala Phe Leu Glu Phe Leu Lys
             180                 185                 190        
 Gln Glu Gln Glu Ala Ser Pro Asp Arg Thr Thr Leu Tyr Ser Leu Met
         195                 200                 205            
 Met Lys Pro Ile Gln Arg Phe Pro Gln Phe Ile Leu Leu Leu Gln Asp
     210                 215                 220                
 Met Leu Lys Asn Thr Ser Lys Gly His Pro Asp Arg Leu Pro Leu Gln
 225                 230                 235                 240
 Met Ala Leu Thr Glu Leu Glu Thr Leu Ala Glu Lys Leu Asn Glu Arg
                 245                 250                 255    
 Lys Arg Asp Ala Asp Gln Arg Cys Glu Val Lys Gln Ile Ala Lys Ala
             260                 265                 270        
 Ile Asn Glu Arg Tyr Leu Asn Lys Leu Leu Ser Ser Gly Ser Arg Tyr
         275                 280                 285            
 Leu Ile Arg Ser Asp Asp Met Ile Glu Thr Val Tyr Asn Asp Arg Gly
     290                 295                 300                
 Glu Ile Val Lys Thr Lys Glu Arg Arg Val Phe Met Leu Asn Asp Val
 305                 310                 315                 320
 Leu Met Cys Ala Thr Val Ser Ser Arg Pro Ser His Asp Ser Arg Val
                 325                 330                 335    
 Met Ser Ser Gln Arg Tyr Leu Leu Lys Trp Ser Val Pro Leu Gly His
             340                 345                 350        
 Val Asp Ala Ile Glu Tyr Gly Ser Ser Ala Gly Thr Gly Glu His Ser
         355                 360                 365            
 Arg His Leu Ala Val His Pro Pro Glu Ser Leu Ala Val Val Ala Asn
     370                 375                 380                
 Ala Lys Pro Asn Lys Val Tyr Met Gly Pro Gly Gln Leu Tyr Gln Asp
 385                 390                 395                 400
 Leu Gln Asn Leu Leu His Asp Leu Asn Val Ile Gly Gln Ile Thr Gln
                 405                 410                 415    
 Leu Ile Gly Asn Leu Lys Gly Asn Tyr Gln Asn Leu Asn Gln Ser Val
             420                 425                 430        
 Ala His Asp Trp Thr Ser Gly Leu Gln Arg Leu Ile Leu Lys Lys Glu
         435                 440                 445            
 Asp Glu Ile Arg Ala Ala Asp Cys Cys Arg Ile Gln Leu Gln Leu Pro
     450                 455                 460                
 Gly Lys Gln Asp Lys Ser Gly Arg Pro Thr Phe Phe Thr Ala Val Phe
 465                 470                 475                 480
 Lys Thr Phe Thr Pro Ala Ile Lys Glu Ser Trp Val Asn Ser Leu Gln
                 485                 490                 495    
 Met Ala Lys Leu Ala Leu Glu Glu Glu Asn His Met Gly Trp Phe Cys
             500                 505                 510        
 Val Glu Asp Asp Gly Asn His Ile Lys Lys Glu Lys His Pro Leu Leu
         515                 520                 525            
 Val Gly His Met Pro Val Met Val Ala Lys Gln Gln Glu Phe Lys Ile
     530                 535                 540                
 Gly Ser Cys Thr His Gln Met Gly Gln Ile Ala Ile Val Ser Phe Gln
 545                 550                 555                 560
 Asn Ser Thr Pro Lys Val Ile Glu Cys Phe Asn Val Glu Ser Arg Ile
                 565                 570                 575    
 Leu Cys Met Leu Tyr Val Pro Val Glu Glu Lys Arg Arg Glu Pro Gly
             580                 585                 590        
 Ala Pro Pro Asp Pro Glu Thr Pro Ala Val Arg Ala Ser Asp Val Pro
         595                 600                 605            
 Thr Ile Cys Val Gly Thr Glu Glu Gly Ser Ile Ser Ile Tyr Lys Ser
     610                 615                 620                
 Ser Gln Gly Ser Lys Lys Val Arg Leu Gln His Phe Phe Thr Pro Glu
 625                 630                 635                 640
 Lys Ser Ser Val Met Ser Leu Ala Cys Thr Ser Gln Ser Leu Tyr Ala
                 645                 650                 655    
 Gly Leu Val Asn Gly Ala Val Ala Thr Tyr Ala Arg Ala Pro Asp Gly
             660                 665                 670        
 Ser Trp Asp Ser Glu Pro Gln Lys Val Ile Lys Leu Gly Val Leu Pro
         675                 680                 685            
 Val Arg Ser Leu Leu Met Met Glu Asp Thr Leu Trp Ala Ala Ser Gly
     690                 695                 700                
 Gly Gln Val Phe Ile Ile Ser Val Glu Thr His Ala Val Glu Gly Gln
 705                 710                 715                 720
 Leu Glu Ala His Gln Glu Glu Gly Met Val Ile Ser His Met Ala Val
                 725                 730                 735    
 Ser Gly Val Gly Ile Trp Ile Ala Phe Thr Ser Gly Ser Thr Leu Arg
             740                 745                 750        
 Leu Phe His Thr Glu Thr Leu Lys His Leu Gln Asp Ile Asn Ile Ala
         755                 760                 765            
 Thr Pro Val His Asn Met Leu Pro Gly His Gln Arg Leu Ser Val Thr
     770                 775                 780                
 Ser Leu Leu Val Cys His Gly Leu Leu Met Val Gly Thr Ser Leu Gly
 785                 790                 795                 800
 Val Leu Val Ala Leu Pro Val Pro Arg Leu Gln Gly Ile Pro Lys Val
                 805                 810                 815    
 Thr Gly Arg Gly Met Val Ser Tyr His Ala His Asn Ser Pro Val Lys
             820                 825                 830        
 Phe Ile Val Leu Ala Thr Ala Leu His Glu Lys Asp Lys Asp Lys Ser
         835                 840                 845            
 Arg Asp Ser Leu Ala Pro Gly Pro Glu Pro Gln Asp Glu Asp Gln Lys
     850                 855                 860                
 Asp Ala Leu Pro Ser Gly Gly Ala Gly Ser Ser Leu Ser Gln Gly Asp
 865                 870                 875                 880
 Pro Asp Ala Ala Ile Trp Leu Gly Asp Ser Leu Gly Ser Met Thr Gln
                 885                 890                 895    
 Lys Ser Asp Leu Ser Ser Ser Ser Gly Ser Leu Ser Leu Ser His Gly
             900                 905                 910        
 Ser Ser Ser Leu Glu His Arg Ser Glu Asp Ser Thr Ile Tyr Asp Leu
         915                 920                 925            
 Leu Lys Asp Pro Val Ser Leu Arg Ser Lys Ala Arg Arg Ala Lys Lys
     930                 935                 940                
 Ala Lys Ala Ser Ser Ala Leu Val Val Cys Gly Gly Gln Gly His Arg
 945                 950                 955                 960
 Arg Val His Arg Lys Ala Arg Gln Pro His Gln Glu Glu Leu Ala Pro
                 965                 970                 975    
 Thr Val Met Val Trp Gln Ile Pro Leu Leu Asn Ile
             980                 985            



      <210> 2941
      <211> 831
      <212> PRT
      <213> Homo sapiens


      <400> 2941
 Met Thr Leu Ala Leu Ala Tyr Leu Leu Ala Leu Pro Gln Val Leu Asp
   1               5                  10                  15    
 Ala Asn Arg Cys Phe Glu Lys Gln Ser Pro Ser Ala Leu Ser Leu Gln
              20                  25                  30        
 Leu Ala Ala Tyr Tyr Tyr Ser Leu Gln Ile Tyr Ala Arg Leu Ala Pro
          35                  40                  45            
 Cys Phe Arg Asp Lys Cys His Pro Leu Tyr Arg Ala Asp Pro Lys Glu
      50                  55                  60                
 Leu Ile Lys Met Val Thr Arg His Val Thr Arg His Glu His Glu Ala
  65                  70                  75                  80
 Trp Pro Glu Asp Leu Ile Ser Leu Thr Lys Gln Leu His Cys Tyr Asn
                  85                  90                  95    
 Glu Arg Leu Leu Asp Phe Thr Gln Ala Gln Ile Leu Gln Gly Leu Arg
             100                 105                 110        
 Lys Gly Val Asp Val Gln Arg Phe Thr Ala Asp Asp Gln Tyr Lys Arg
         115                 120                 125            
 Glu Thr Ile Leu Gly Leu Ala Glu Thr Leu Glu Glu Ser Val Tyr Ser
     130                 135                 140                
 Ile Ala Ile Ser Leu Ala Gln Arg Tyr Ser Val Ser Arg Trp Glu Val
 145                 150                 155                 160
 Phe Met Thr His Leu Glu Phe Leu Phe Thr Asp Ser Gly Leu Ser Thr
                 165                 170                 175    
 Leu Glu Ile Glu Asn Arg Ala Gln Asp Leu His Leu Phe Glu Thr Leu
             180                 185                 190        
 Lys Thr Asp Pro Glu Ala Phe His Gln His Met Val Lys Tyr Ile Tyr
         195                 200                 205            
 Pro Thr Ile Gly Gly Phe Asp His Glu Arg Leu Gln Tyr Tyr Phe Thr
     210                 215                 220                
 Leu Leu Glu Asn Cys Gly Cys Ala Asp Leu Gly Asn Cys Ala Ile Lys
 225                 230                 235                 240
 Pro Glu Thr His Ile Arg Leu Leu Lys Lys Phe Lys Val Val Ala Ser
                 245                 250                 255    
 Gly Leu Asn Tyr Lys Lys Leu Thr Asp Glu Asn Met Ser Pro Leu Glu
             260                 265                 270        
 Ala Leu Glu Pro Val Leu Ser Ser Gln Asn Ile Leu Ser Ile Ser Lys
         275                 280                 285            
 Leu Val Pro Lys Ile Pro Glu Lys Asp Gly Gln Met Leu Ser Pro Ser
     290                 295                 300                
 Ser Leu Tyr Thr Ile Trp Leu Gln Lys Leu Phe Trp Thr Gly Asp Pro
 305                 310                 315                 320
 His Leu Ile Lys Gln Val Pro Gly Ser Ser Pro Glu Trp Leu His Ala
                 325                 330                 335    
 Tyr Asp Val Cys Met Lys Tyr Phe Asp Arg Leu His Pro Gly Asp Leu
             340                 345                 350        
 Ile Thr Val Val Asp Ala Val Thr Phe Ser Pro Lys Ala Val Thr Lys
         355                 360                 365            
 Leu Ser Val Glu Ala Arg Lys Glu Met Thr Arg Lys Ala Ile Lys Thr
     370                 375                 380                
 Val Lys His Phe Ile Glu Lys Pro Arg Lys Arg Asn Ser Glu Asp Glu
 385                 390                 395                 400
 Ala Gln Glu Ala Lys Asp Ser Lys Val Thr Tyr Ala Asp Thr Leu Asn
                 405                 410                 415    
 His Leu Glu Lys Ser Leu Ala His Leu Glu Thr Leu Ser His Ser Phe
             420                 425                 430        
 Ile Leu Ser Leu Lys Asn Ser Glu Gln Glu Thr Leu Gln Lys Tyr Ser
         435                 440                 445            
 His Leu Tyr Asp Leu Ser Arg Ser Glu Lys Glu Lys Leu His Asp Glu
     450                 455                 460                
 Ala Val Ala Ile Cys Leu Asp Gly Gln Pro Leu Ala Met Ile Gln Gln
 465                 470                 475                 480
 Leu Leu Glu Val Ala Val Gly Pro Leu Asp Ile Ser Pro Lys Asp Ile
                 485                 490                 495    
 Val Gln Ser Ala Ile Met Lys Ile Ile Ser Ala Leu Ser Gly Gly Ser
             500                 505                 510        
 Ala Asp Leu Gly Gly Pro Arg Asp Pro Leu Lys Val Leu Glu Gly Val
         515                 520                 525            
 Val Ala Ala Val His Ala Ser Val Asp Lys Gly Glu Glu Leu Val Ser
     530                 535                 540                
 Pro Glu Asp Leu Leu Glu Trp Leu Arg Pro Phe Cys Ala Asp Asp Ala
 545                 550                 555                 560
 Trp Pro Val Arg Pro Arg Ile His Val Leu Gln Ile Leu Gly Gln Ser
                 565                 570                 575    
 Phe His Leu Thr Glu Glu Asp Ser Lys Leu Leu Val Phe Phe Arg Thr
             580                 585                 590        
 Glu Ala Ile Leu Lys Ala Ser Trp Pro Gln Arg Gln Val Asp Ile Ala
         595                 600                 605            
 Asp Ile Glu Asn Glu Glu Asn Arg Tyr Cys Leu Phe Met Glu Leu Leu
     610                 615                 620                
 Glu Ser Ser His His Glu Ala Glu Phe Gln His Leu Val Leu Leu Leu
 625                 630                 635                 640
 Gln Ala Trp Pro Pro Met Lys Ser Glu Tyr Val Ile Thr Asn Asn Pro
                 645                 650                 655    
 Trp Val Arg Leu Ala Thr Val Met Leu Thr Arg Cys Thr Met Glu Asn
             660                 665                 670        
 Lys Glu Gly Leu Gly Asn Glu Val Leu Lys Met Cys Arg Ser Leu Tyr
         675                 680                 685            
 Asn Thr Lys Gln Met Leu Pro Ala Glu Gly Val Lys Glu Leu Cys Leu
     690                 695                 700                
 Leu Leu Leu Asn Gln Ser Leu Leu Leu Pro Ser Leu Lys Leu Leu Leu
 705                 710                 715                 720
 Glu Ser Arg Asp Glu His Leu His Glu Met Ala Leu Glu Gln Ile Thr
                 725                 730                 735    
 Ala Val Thr Thr Val Asn Asp Ser Asn Cys Asp Gln Glu Leu Leu Ser
             740                 745                 750        
 Leu Leu Leu Asp Ala Lys Leu Leu Val Lys Cys Val Ser Thr Pro Phe
         755                 760                 765            
 Tyr Pro Arg Ile Val Asp His Leu Leu Ala Ser Leu Gln Gln Gly Arg
     770                 775                 780                
 Trp Asp Ala Glu Glu Leu Gly Arg His Leu Arg Glu Ala Gly His Glu
 785                 790                 795                 800
 Ala Glu Ala Gly Ser Leu Leu Leu Ala Val Arg Gly Thr His Gln Ala
                 805                 810                 815    
 Phe Arg Thr Phe Ser Thr Ala Leu Arg Ala Ala Gln His Trp Val
             820                 825                 830    



      <210> 2942
      <211> 213
      <212> PRT
      <213> Homo sapiens

      <220>
      <221> misc_feature
      <222> (1)...(213)
      <223> Xaa = any amino acid or symbol as shown in the table 8 as set forth in Example 2


      <400> 2942
 Cys Trp Ser Gly His Ser Cys Leu Ala Pro Pro His Gly Arg Val Gly
   1               5                  10                  15    
 Cys Tyr Arg Gly His Pro Gln Gly His Gly Gly Ala Arg Gln Ser Ser
              20                  25                  30        
 Pro Ser Ser Pro Pro Gly Ser Pro Arg Gln Lys Val Gly Thr Ser Gly
          35                  40                  45            
 Arg Glu Gly Leu Pro Gly Leu Gly Ala Ser Cys Ala Glu Ser Glu Pro
      50                  55                  60                
 Gly Thr Gly Asp Ala Gly Ala Pro Gln Pro Arg Glu Val His Ile Trp
  65                  70                  75                  80
 Gly Cys Gln Val Ala Pro Gly Pro Leu Gly Gln Pro Pro Ala Pro Leu
                  85                  90                  95    
 Ser Ser Val Pro Arg Ala Ser Ala Ser Gln Asp Gly Ala Ala Ser Val
             100                 105                 110        
 Leu Gly Pro Ser Cys Pro Leu Gly Ser Arg Val Leu Arg Pro Ala Pro
         115                 120                 125            
 Leu Ala Val Gly Ala Val His Ser Leu Pro Gln Ala Arg Gly Arg Cys
     130                 135                 140                
 Ser Pro Gln Glu Glu Gly Ala Glu Ala Ala Gly Glu Ala Ala Gly Gln
 145                 150                 155                 160
 Cys Asp Gly Gly Gly Ser Gly Glu Cys Gln Ala Val Pro Gly Thr Arg
                 165                 170                 175    
 Val Gly Ser Ala Gly Asp Arg Pro Ala Phe Leu Ala Pro Ser Pro Tyr
             180                 185                 190        
 Xaa Ser Gly Pro Thr Ser Ala Pro Ser Ala Ser Arg Thr Pro Asp Cys
         195                 200                 205            
 Thr Ser Cys Thr Arg
     210            



      <210> 2943
      <211> 1470
      <212> PRT
      <213> Homo sapiens


      <400> 2943
 Tyr Leu Asp Met Met Ser Phe Val Gln Lys Gly Ser Trp Leu Leu Leu
   1               5                  10                  15    
 Ala Leu Leu His Pro Thr Ile Ile Leu Ala Gln Gln Glu Ala Val Glu
              20                  25                  30        
 Gly Gly Cys Ser His Leu Gly Gln Ser Tyr Ala Asp Arg Asp Val Trp
          35                  40                  45            
 Lys Pro Glu Pro Cys Gln Ile Cys Val Cys Asp Ser Gly Ser Val Leu
      50                  55                  60                
 Cys Asp Asp Ile Ile Cys Asp Asp Gln Glu Leu Asp Cys Pro Asn Pro
  65                  70                  75                  80
 Glu Ile Pro Phe Gly Glu Cys Cys Ala Val Cys Pro Gln Pro Pro Thr
                  85                  90                  95    
 Ala Pro Thr Arg Pro Pro Asn Gly Gln Gly Pro Gln Gly Pro Lys Gly
             100                 105                 110        
 Asp Pro Gly Pro Pro Gly Ile Pro Gly Arg Asn Gly Asp Pro Gly Ile
         115                 120                 125            
 Pro Gly Gln Pro Gly Ser Pro Gly Ser Pro Gly Pro Pro Gly Ile Cys
     130                 135                 140                
 Glu Ser Arg Pro Thr Gly Pro Gln Asn Tyr Ser Pro Gln Tyr Asp Ser
 145                 150                 155                 160
 Tyr Asp Val Lys Ser Gly Gly Val Ala Val Gly Gly Leu Ala Gly Tyr
                 165                 170                 175    
 Pro Gly Pro Ala Gly Pro Pro Gly Pro Pro Gly Pro Pro Gly Thr Ser
             180                 185                 190        
 Gly His Pro Gly Ser Pro Gly Ser Pro Gly Tyr Gln Gly Pro Pro Gly
         195                 200                 205            
 Glu Pro Gly Gln Ala Gly Pro Ser Gly Pro Pro Gly Pro Pro Gly Ala
     210                 215                 220                
 Ile Gly Pro Ser Gly Pro Ala Gly Lys Asp Gly Glu Ser Gly Arg Pro
 225                 230                 235                 240
 Gly Arg Pro Gly Glu Arg Gly Leu Pro Gly Pro Pro Gly Ile Lys Gly
                 245                 250                 255    
 Pro Ala Gly Ile Pro Gly Phe Pro Gly Met Lys Gly His Arg Gly Phe
             260                 265                 270        
 Asp Gly Arg Asn Gly Glu Lys Gly Glu Thr Gly Ala Pro Gly Leu Lys
         275                 280                 285            
 Gly Glu Asn Gly Leu Pro Gly Glu Asn Gly Ala Pro Gly Pro Met Gly
     290                 295                 300                
 Pro Arg Gly Ala Pro Gly Glu Arg Gly Arg Pro Gly Leu Pro Gly Ala
 305                 310                 315                 320
 Ala Gly Ala Arg Gly Asn Asp Gly Ala Arg Gly Ser Asp Gly Gln Pro
                 325                 330                 335    
 Gly Pro Pro Gly Pro Pro Gly Thr Ala Gly Phe Pro Gly Ser Pro Gly
             340                 345                 350        
 Ala Lys Gly Glu Val Gly Pro Ala Gly Ser Pro Gly Ser Asn Gly Ala
         355                 360                 365            
 Pro Gly Gln Arg Gly Glu Pro Gly Pro Gln Gly His Ala Gly Ala Gln
     370                 375                 380                
 Gly Pro Pro Gly Pro Pro Gly Ile Asn Gly Ser Pro Gly Gly Lys Gly
 385                 390                 395                 400
 Glu Met Gly Pro Ala Gly Ile Pro Gly Ala Pro Gly Leu Met Gly Ala
                 405                 410                 415    
 Arg Gly Pro Pro Gly Pro Ala Gly Ala Asn Gly Ala Pro Gly Leu Arg
             420                 425                 430        
 Gly Gly Ala Gly Glu Pro Gly Lys Asn Gly Ala Lys Gly Glu Pro Gly
         435                 440                 445            
 Pro Arg Gly Glu Arg Gly Glu Ala Gly Ile Pro Gly Val Pro Gly Ala
     450                 455                 460                
 Lys Gly Glu Asp Gly Lys Asp Gly Ser Pro Gly Glu Pro Gly Ala Asn
 465                 470                 475                 480
 Gly Leu Pro Gly Ala Ala Gly Glu Arg Gly Ala Pro Gly Phe Arg Gly
                 485                 490                 495    
 Pro Ala Gly Pro Asn Gly Ile Pro Gly Glu Lys Gly Pro Ala Gly Glu
             500                 505                 510        
 Arg Gly Ala Pro Gly Pro Ala Gly Pro Arg Gly Ala Ala Gly Glu Pro
         515                 520                 525            
 Gly Arg Asp Gly Val Pro Gly Gly Pro Gly Met Arg Gly Met Pro Gly
     530                 535                 540                
 Ser Pro Gly Gly Pro Gly Ser Asp Gly Lys Pro Gly Pro Pro Gly Ser
 545                 550                 555                 560
 Gln Gly Glu Ser Gly Arg Pro Gly Pro Pro Gly Pro Ser Gly Pro Arg
                 565                 570                 575    
 Gly Gln Pro Gly Val Met Gly Phe Pro Gly Pro Lys Gly Asn Asp Gly
             580                 585                 590        
 Ala Pro Gly Lys Asn Gly Glu Arg Gly Gly Pro Gly Gly Pro Gly Pro
         595                 600                 605            
 Gln Gly Pro Pro Gly Lys Asn Gly Glu Thr Gly Pro Gln Gly Pro Pro
     610                 615                 620                
 Gly Pro Thr Gly Pro Gly Gly Asp Lys Gly Asp Thr Gly Pro Pro Gly
 625                 630                 635                 640
 Pro Gln Gly Leu Gln Gly Leu Pro Gly Thr Gly Gly Pro Pro Gly Glu
                 645                 650                 655    
 Asn Gly Lys Pro Gly Glu Pro Gly Pro Lys Gly Asp Ala Gly Ala Pro
             660                 665                 670        
 Gly Ala Pro Gly Gly Lys Gly Asp Ala Gly Ala Pro Gly Glu Arg Gly
         675                 680                 685            
 Pro Pro Gly Leu Ala Gly Ala Pro Gly Leu Arg Gly Gly Ala Gly Pro
     690                 695                 700                
 Pro Gly Pro Glu Gly Gly Lys Gly Ala Ala Gly Pro Pro Gly Pro Pro
 705                 710                 715                 720
 Gly Ala Ala Gly Thr Pro Gly Leu Gln Gly Met Pro Gly Glu Arg Gly
                 725                 730                 735    
 Gly Leu Gly Ser Pro Gly Pro Lys Gly Asp Lys Gly Glu Pro Gly Gly
             740                 745                 750        
 Pro Gly Ala Asp Gly Val Pro Gly Lys Asp Gly Pro Arg Gly Pro Thr
         755                 760                 765            
 Gly Pro Ile Gly Pro Pro Gly Pro Ala Gly Gln Pro Gly Asp Lys Gly
     770                 775                 780                
 Glu Gly Gly Ala Pro Gly Leu Pro Gly Ile Ala Gly Pro Arg Gly Ser
 785                 790                 795                 800
 Pro Gly Glu Arg Gly Glu Thr Gly Pro Pro Gly Pro Ala Gly Phe Pro
                 805                 810                 815    
 Gly Ala Pro Gly Gln Asn Gly Glu Pro Gly Gly Lys Gly Glu Arg Gly
             820                 825                 830        
 Ala Pro Gly Glu Lys Gly Glu Gly Gly Pro Pro Gly Val Ala Gly Pro
         835                 840                 845            
 Pro Gly Gly Ser Gly Pro Ala Gly Pro Pro Gly Pro Gln Gly Val Lys
     850                 855                 860                
 Gly Glu Arg Gly Ser Pro Gly Gly Pro Gly Ala Ala Gly Phe Pro Gly
 865                 870                 875                 880
 Ala Arg Gly Leu Pro Gly Pro Pro Gly Ser Asn Gly Asn Pro Gly Pro
                 885                 890                 895    
 Pro Gly Pro Ser Gly Ser Pro Gly Lys Asp Gly Pro Pro Gly Pro Ala
             900                 905                 910        
 Gly Asn Thr Gly Ala Pro Gly Ser Pro Gly Val Ser Gly Pro Lys Gly
         915                 920                 925            
 Asp Ala Gly Gln Pro Gly Glu Lys Gly Ser Pro Gly Ala Gln Gly Pro
     930                 935                 940                
 Pro Gly Ala Pro Gly Pro Leu Gly Ile Ala Gly Ile Thr Gly Ala Arg
 945                 950                 955                 960
 Gly Leu Ala Gly Pro Pro Gly Met Pro Gly Pro Arg Gly Ser Pro Gly
                 965                 970                 975    
 Pro Gln Gly Val Lys Gly Glu Ser Gly Lys Pro Gly Ala Asn Gly Leu
             980                 985                 990        
 Ser Gly Glu Arg Gly Pro Pro Gly Pro Gln Gly Leu Pro Gly Leu Ala
         995                1000                1005            
 Gly Thr Ala Gly Glu Pro Gly Arg Asp Gly Asn Pro Gly Ser Asp Gly
    1010                1015                1020                
 Leu Pro Gly Arg Asp Gly Ser Pro Gly Gly Lys Gly Asp Arg Gly Glu
1025                1030                1035                1040
 Asn Gly Ser Pro Gly Ala Pro Gly Ala Pro Gly His Pro Gly Pro Pro
                1045                1050                1055    
 Gly Pro Val Gly Pro Ala Gly Lys Ser Gly Asp Arg Gly Glu Ser Gly
            1060                1065                1070        
 Pro Ala Gly Pro Ala Gly Ala Pro Gly Pro Ala Gly Ser Arg Gly Ala
        1075                1080                1085            
 Pro Gly Pro Gln Gly Pro Arg Gly Asp Lys Gly Glu Thr Gly Glu Arg
    1090                1095                1100                
 Gly Ala Ala Gly Ile Lys Gly His Arg Gly Phe Pro Gly Asn Pro Gly
1105                1110                1115                1120
 Ala Pro Gly Ser Pro Gly Pro Ala Gly Gln Gln Gly Ala Ile Gly Ser
                1125                1130                1135    
 Pro Gly Pro Ala Gly Pro Arg Gly Pro Val Gly Pro Ser Gly Pro Pro
            1140                1145                1150        
 Gly Lys Asp Gly Thr Ser Gly His Pro Gly Pro Ile Gly Pro Pro Gly
        1155                1160                1165            
 Pro Arg Gly Asn Arg Gly Glu Arg Gly Ser Glu Gly Ser Pro Gly His
    1170                1175                1180                
 Pro Gly Gln Pro Gly Pro Pro Gly Pro Pro Gly Ala Pro Gly Pro Cys
1185                1190                1195                1200
 Cys Gly Gly Val Gly Ala Ala Ala Ile Ala Gly Ile Gly Gly Glu Lys
                1205                1210                1215    
 Ala Gly Gly Phe Ala Pro Tyr Tyr Gly Asp Glu Pro Met Asp Phe Lys
            1220                1225                1230        
 Ile Asn Thr Asp Glu Ile Met Thr Ser Leu Lys Ser Val Asn Gly Gln
        1235                1240                1245            
 Ile Glu Ser Leu Ile Ser Pro Asp Gly Ser Arg Lys Asn Pro Ala Arg
    1250                1255                1260                
 Asn Cys Arg Asp Leu Lys Phe Cys His Pro Glu Leu Lys Ser Gly Glu
1265                1270                1275                1280
 Tyr Trp Val Asp Pro Asn Gln Gly Cys Lys Leu Asp Ala Ile Lys Val
                1285                1290                1295    
 Phe Cys Asn Met Glu Thr Gly Glu Thr Cys Ile Ser Ala Asn Pro Leu
            1300                1305                1310        
 Asn Val Pro Arg Lys His Trp Trp Thr Asp Ser Ser Ala Glu Lys Lys
        1315                1320                1325            
 His Val Trp Phe Gly Glu Ser Met Asp Gly Gly Phe Gln Phe Ser Tyr
    1330                1335                1340                
 Gly Asn Pro Glu Leu Pro Glu Asp Val Leu Asp Val Gln Leu Ala Phe
1345                1350                1355                1360
 Leu Arg Leu Leu Ser Ser Arg Ala Ser Gln Asn Ile Thr Tyr His Cys
                1365                1370                1375    
 Lys Asn Ser Ile Ala Tyr Met Asp Gln Ala Ser Gly Asn Val Lys Lys
            1380                1385                1390        
 Ala Leu Lys Leu Met Gly Ser Asn Glu Gly Glu Phe Lys Ala Glu Gly
        1395                1400                1405            
 Asn Ser Lys Phe Thr Tyr Thr Val Leu Glu Asp Gly Cys Thr Lys His
    1410                1415                1420                
 Thr Gly Glu Trp Ser Lys Thr Val Phe Glu Tyr Arg Thr Arg Lys Ala
1425                1430                1435                1440
 Val Arg Leu Pro Ile Val Asp Ile Ala Pro Tyr Asp Ile Gly Gly Pro
                1445                1450                1455    
 Asp Gln Glu Phe Gly Val Asp Val Gly Pro Val Cys Phe Leu
            1460                1465                1470



      <210> 2944
      <211> 138
      <212> PRT
      <213> Homo sapiens


      <400> 2944
 Leu Leu Ser Ala Ile Arg Gln Leu Gln Gln Leu Leu Lys Gly Gln Glu
   1               5                  10                  15    
 Thr Arg Phe Ala Glu Gly Ile Arg His Met Lys Ser Arg Leu Ala Ala
              20                  25                  30        
 Leu Gln Asn Ser Val Gly Arg Val Gly Pro Asp Ala Leu Pro Val Ser
          35                  40                  45            
 Cys Pro Ala Leu Asn Thr Pro Ala Asp Gly Arg Lys Phe Gly Ser Lys
      50                  55                  60                
 Tyr Leu Val Asp His Glu Val His Phe Thr Cys Asn Pro Gly Phe Arg
  65                  70                  75                  80
 Leu Val Gly Pro Ser Ser Val Val Cys Leu Pro Asn Gly Thr Trp Thr
                  85                  90                  95    
 Gly Glu Gln Pro His Cys Arg Gly Ile Ser Glu Cys Ser Ser Gln Pro
             100                 105                 110        
 Cys Gln Asn Gly Gly Thr Cys Val Glu Gly Val Asn Gln Ala Arg Cys
         115                 120                 125            
 Ile Leu Pro Pro Arg Arg Thr Trp Asn Arg
     130                 135            



      <210> 2945
      <211> 157
      <212> PRT
      <213> Homo sapiens

      <220>
      <221> misc_feature
      <222> (1)...(157)
      <223> Xaa = any amino acid or symbol as shown in the table 8 as set forth in Example 2


      <400> 2945
 Pro Arg Val Arg Ser Gly His Ser Met Asp Met Arg Val Pro Ala Gln
   1               5                  10                  15    
 Leu Leu Gly Leu Leu Leu Leu Trp Leu Arg Gly Ala Asn Cys Asp Ile
              20                  25                  30        
 Gln Val Thr Gln Ser Pro Asp Ser Leu Ser Ala Ser Val Gly Asp Lys
          35                  40                  45            
 Val Thr Ile Thr Cys Arg Ala Ser Gln Gly Ile Ser Asn Gly Leu Ser
      50                  55                  60                
 Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Thr Leu Leu Ile Tyr Ala
  65                  70                  75                  80
 Ala Ser Ser Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly Ser Gly
                  85                  90                  95    
 Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro Glu Asp
             100                 105                 110        
 Val Ala Thr Tyr Tyr Cys Leu Gln Asp Tyr Thr Thr Pro Phe Thr Val
         115                 120                 125            
 Leu Gln Ala Ile Thr Lys Thr Pro Gln Arg Arg Asp Val Xaa Val Cys
     130                 135                 140                
 Thr Val Leu Ala Thr Pro Pro Gly Val Ile Asn Trp Leu
 145                 150                 155        



      <210> 2946
      <211> 154
      <212> PRT
      <213> Homo sapiens


      <400> 2946
 Gly Gly Ile His Leu Gly Ser Ser Ala Lys Ile Lys Cys Asn Ser Cys
   1               5                  10                  15    
 Gln Ser Tyr His Glu Ser Thr Lys Gln Leu Thr Met Lys Lys Leu Pro
              20                  25                  30        
 Ile Val Ala Cys Phe His Leu Lys Arg Phe Glu His Val Gly Lys Gln
          35                  40                  45            
 Arg Arg Lys Ile Asn Thr Phe Ile Ser Phe Pro Leu Glu Leu Asp Met
      50                  55                  60                
 Thr Pro Phe Leu Ala Ser Thr Lys Glu Ser Arg Met Lys Glu Gly Gln
  65                  70                  75                  80
 Pro Pro Thr Asp Cys Val Pro Asn Glu Asn Lys Tyr Ser Leu Phe Ala
                  85                  90                  95    
 Val Ile Asn His His Gly Thr Leu Glu Ser Gly His Tyr Thr Ser Phe
             100                 105                 110        
 Ile Arg Gln Gln Lys Asp Gln Trp Phe Ser Cys Asp Asp Ala Ile Ile
         115                 120                 125            
 Thr Lys Ala Thr Ile Glu Asp Leu Leu Tyr Ser Glu Gly Tyr Leu Leu
     130                 135                 140                
 Phe Tyr His Lys Gln Gly Leu Glu Lys Asp
 145                 150                



      <210> 2947
      <211> 388
      <212> PRT
      <213> Homo sapiens


      <400> 2947
 Leu Pro Pro Thr Pro Val Gln Leu Leu Tyr Pro Val Ser Arg Phe Ser
   1               5                  10                  15    
 Asn Val Lys Ser Leu Gln His Leu Cys Arg Phe Arg Ile Arg Gln Leu
              20                  25                  30        
 Val Arg Ile Asp His Ile Pro Asp Leu Pro Leu Pro Lys Tyr Asn Gly
          35                  40                  45            
 Val Val Arg Phe Gly Thr Gly Met Ser Lys Gly Val Val Gly Arg Pro
      50                  55                  60                
 Leu Ile Ser Tyr Ile Arg Lys Phe Tyr Tyr Tyr Asp Pro Gln Glu Glu
  65                  70                  75                  80
 Val Tyr Leu Ser Leu Lys Glu Ala Gln Leu Ile Ser Lys Gln Lys Gln
                  85                  90                  95    
 Glu Val Glu Pro Ser Thr Pro Leu Ser Val Glu Gly His Pro Gly Arg
             100                 105                 110        
 Gly Val Ala Ala Glu Val Ala Asp Glu Lys Leu Gly Tyr Met Gly Asp
         115                 120                 125            
 Gly Ala Trp Glu Lys Ala Glu Ser Glu Glu Leu Glu Val Gln Lys Pro
     130                 135                 140                
 Gln Val Lys Leu Arg Arg Ala Val Ser Glu Val Ala Arg Pro Ala Ser
 145                 150                 155                 160
 Thr Pro Pro Ile Met Ala Ser Ala Ile Lys Asp Glu Asp Asp Glu Asp
                 165                 170                 175    
 Arg Ile Ile Ala Glu Leu Glu Val Phe Glu Arg Ser Ser Val Ser Ser
             180                 185                 190        
 Leu Pro Pro Thr Pro Arg Arg Gln Leu Ile Pro Thr Leu Leu Ser Pro
         195                 200                 205            
 Gln Asp Leu Gly Pro Pro Gly Gly Ser Ala Pro Gly Pro Thr Arg Lys
     210                 215                 220                
 Arg Thr Gln His Pro Gln Gly Arg Arg Phe Asn Lys Leu Glu Gly Lys
 225                 230                 235                 240
 Lys Lys Arg Ser Lys Glu Glu Ser Cys Lys Leu Thr His Val Lys Gly
                 245                 250                 255    
 Thr Thr Gly Lys Thr His Ser Val Leu Leu Pro Tyr Tyr Leu Gly Leu
             260                 265                 270        
 Glu Cys Leu Arg Gln Leu Ala Gln Ala Ser Cys Leu Arg Gly Arg Thr
         275                 280                 285            
 Ala Gly Thr Ile Val Lys Thr Gln Ala Pro Gly Gly Ala Pro Pro Pro
     290                 295                 300                
 Ser Ser Phe His Ser Leu Lys Leu Arg Ser Gly Ser Gly Leu Cys Thr
 305                 310                 315                 320
 Thr Thr Val Trp Arg Arg Gln Leu Leu Arg Arg Arg Arg Val Ser Gly
                 325                 330                 335    
 Asp Ser Gly Arg Arg Arg Arg Thr Ala Ser Met Ala Asp Ala Ala Thr
             340                 345                 350        
 Pro Ser Arg Arg Arg Ser Ala Ser Lys Arg Glu Gly Arg Glu Ala Ser
         355                 360                 365            
 Ala Ala Ala Gly Gly Arg Ser Asp Ser Trp Leu Leu Asp Asp Ala Glu
     370                 375                 380                
 Pro Gly Ala His
 385            



      <210> 2948
      <211> 232
      <212> PRT
      <213> Homo sapiens


      <400> 2948
 Arg Arg Tyr Lys Ser Gly Thr Glu Val Asn Asn Thr Asp Gly Gly Ile
   1               5                  10                  15    
 Ala Arg Leu Ile Val Phe Gly Thr Gly Gln Lys Asp Trp Thr Ala Thr
              20                  25                  30        
 Asp Pro Lys Glu Pro Ala Asp Leu Val Ala Ile Ala Phe Gly Gly Val
          35                  40                  45            
 Cys Val Gly Phe Ser Asn Ala Lys Phe Gly His Pro Asn Asn Ile Ile
      50                  55                  60                
 Gly Val Gly Gly Ala Lys Ser Met Ala Asp Gly Trp Glu Thr Ala Arg
  65                  70                  75                  80
 Arg Leu Asp Arg Pro Pro Ile Leu Glu Asn Asp Glu Asn Gly Ile Leu
                  85                  90                  95    
 Leu Val Pro Gly Cys Glu Trp Ala Val Phe Arg Leu Ala His Pro Gly
             100                 105                 110        
 Val Ile Thr Arg Ile Glu Ile Asp Thr Lys Tyr Phe Glu Gly Asn Ala
         115                 120                 125            
 Pro Asp Ser Cys Lys Val Asp Gly Cys Ile Leu Thr Thr Gln Glu Glu
     130                 135                 140                
 Ala Val Ile Arg Gln Lys Trp Ile Leu Pro Ala His Lys Trp Lys Pro
 145                 150                 155                 160
 Leu Leu Pro Val Thr Lys Leu Ser Pro Asn Gln Ser His Leu Phe Asp
                 165                 170                 175    
 Ser Leu Thr Leu Glu Leu Gln Asp Val Ile Thr His Ala Arg Leu Thr
             180                 185                 190        
 Ile Val Pro Asp Gly Gly Val Asn Arg Leu Arg Leu Arg Gly Phe Pro
         195                 200                 205            
 Ser Ser Ile Cys Leu Leu Arg Pro Arg Glu Lys Pro Met Leu Lys Phe
     210                 215                 220                
 Ser Val Ser Phe Lys Ala Asn Pro
 225                 230        



      <210> 2949
      <211> 133
      <212> PRT
      <213> Homo sapiens


      <400> 2949
 Met Trp Pro Arg Gly Lys Gly Val Arg Ser Gln Gly Cys Trp Glu Leu
   1               5                  10                  15    
 Arg Leu Cys Leu Ala Gly Phe Ile Ile Asp Gln Ala Glu Thr Gln Glu
              20                  25                  30        
 His Pro Ser Thr Ala Arg Arg Glu Asn Leu Arg Lys Phe Tyr Lys Gly
          35                  40                  45            
 Lys Lys Tyr Gln Pro Val Asp Leu Gln Pro Lys Lys Thr Cys Ala Met
      50                  55                  60                
 Ser His Cys Leu Asn Lys His Glu Glu Asn Leu Lys Gly Lys Lys Gln
  65                  70                  75                  80
 Gln Trp Lys Glu Trp Leu Ser Pro Leu Arg Lys Glu Glu Gly Ala Pro
                  85                  90                  95    
 Val Pro Ala Glu Glu Gly Leu Pro Gly Cys Pro Gly Ile Gln Pro Arg
             100                 105                 110        
 Lys Ala Ala Leu Pro Gly Asn Gly Leu Glu Gln Met Ser Ala Tyr Ser
         115                 120                 125            
 Ile Ala Pro Ser Trp
     130            



      <210> 2950
      <211> 89
      <212> PRT
      <213> Homo sapiens


      <400> 2950
 Gly Ser Val Ala Leu His Val Glu Lys Leu Pro Asn Glu Pro Asn Arg
   1               5                  10                  15    
 Leu Leu Ile Leu His Gly Phe Leu Asp Glu Asn Val His Phe Phe His
              20                  25                  30        
 Thr Asn Phe Leu Val Ser Gln Leu Ile Arg Ala Gly Lys Pro Tyr Gln
          35                  40                  45            
 Leu Gln Val Ala Leu Pro Pro Val Ser Pro Gln Ile Tyr Pro Asn Glu
      50                  55                  60                
 Arg His Ser Ile Arg Cys Pro Glu Ser Gly Glu His Tyr Glu Val Thr
  65                  70                  75                  80
 Leu Leu His Phe Leu Gln Glu Tyr Leu
                  85                



      <210> 2951
      <211> 172
      <212> PRT
      <213> Homo sapiens

      <220>
      <221> misc_feature
      <222> (1)...(172)
      <223> Xaa = any amino acid or symbol as shown in the table 8 as set forth in Example 2


      <400> 2951
 Asn Ser Glu Thr Arg Glu His Asn His Arg Tyr Val Pro Gln Arg Glu
   1               5                  10                  15    
 Thr Ser Gly Gly Thr Asp Gly Trp Lys Ser Lys Gln Pro Glu Xaa Leu
              20                  25                  30        
 Xaa Arg Arg Gln Leu Val Gln Ser Trp Ala Lys Ser Xaa Asn Gln Pro
          35                  40                  45            
 Lys Leu Pro Ser Ser Pro His Xaa Glu Leu Pro Trp Val Thr Pro Ser
      50                  55                  60                
 Ala Arg Asn Phe Arg Ser Gly Pro Tyr Ser Pro Pro Pro Pro Pro Pro
  65                  70                  75                  80
 Pro Gln Pro Leu Pro Ser Ser His Leu Ser Ser Leu His Phe Tyr Ser
                  85                  90                  95    
 Pro Phe Val Ser Tyr Thr Ser Phe Asp Leu Tyr Ser Ser Ser Tyr His
             100                 105                 110        
 Ser Tyr Leu Met Asp Glu Asp Thr Val Glu Pro Lys Glu Leu Arg Ser
         115                 120                 125            
 Ser Gln Lys Val Ile Gly His Ser Phe Thr Gly Phe Gln Pro Thr Leu
     130                 135                 140                
 Ser Ala Asn Pro Tyr Asp Arg Gly Asp Gly Lys Ile Ile Glu Leu Leu
 145                 150                 155                 160
 Pro Arg Lys Ala Gln Thr Phe Pro Val Val Arg Thr
                 165                 170        



      <210> 2952
      <211> 467
      <212> PRT
      <213> Homo sapiens


      <400> 2952
 Thr Ala Cys Arg Ile Arg Thr Ser Leu Asn Arg Gly Ile Ala Ala Val
   1               5                  10                  15    
 Lys Glu Asp Ala Val Glu Met Leu Ala Ser Tyr Gly Leu Ala Tyr Ser
              20                  25                  30        
 Leu Met Lys Phe Phe Thr Gly Pro Met Ser Asp Phe Lys Asn Val Gly
          35                  40                  45            
 Leu Val Phe Val Asn Ser Lys Arg Asp Arg Thr Lys Ala Val Leu Cys
      50                  55                  60                
 Met Val Val Ala Gly Ala Ile Ala Ala Val Phe His Thr Leu Ile Ala
  65                  70                  75                  80
 Tyr Ser Asp Leu Gly Tyr Tyr Ile Ile Asn Lys Leu His His Val Asp
                  85                  90                  95    
 Glu Ser Val Gly Ser Lys Thr Arg Arg Ala Phe Leu Tyr Leu Ala Ala
             100                 105                 110        
 Phe Pro Phe Met Asp Ala Met Ala Trp Thr His Ala Gly Ile Leu Leu
         115                 120                 125            
 Lys His Lys Tyr Ser Phe Leu Val Gly Cys Ala Ser Ile Ser Asp Val
     130                 135                 140                
 Ile Ala Gln Val Val Phe Val Ala Ile Leu Leu His Ser His Leu Glu
 145                 150                 155                 160
 Cys Arg Glu Pro Leu Leu Ile Pro Ile Leu Ser Leu Tyr Met Gly Ala
                 165                 170                 175    
 Leu Val Arg Cys Thr Thr Leu Cys Leu Gly Tyr Tyr Lys Asn Ile His
             180                 185                 190        
 Asp Ile Ile Pro Asp Arg Ser Gly Pro Glu Leu Gly Gly Asp Ala Thr
         195                 200                 205            
 Ile Arg Lys Met Leu Ser Phe Trp Trp Pro Leu Ala Leu Ile Leu Ala
     210                 215                 220                
 Thr Gln Arg Ile Ser Arg Pro Ile Val Asn Leu Phe Val Ser Arg Asp
 225                 230                 235                 240
 Leu Gly Gly Ser Ser Ala Ala Thr Glu Ala Val Ala Ile Leu Thr Ala
                 245                 250                 255    
 Thr Tyr Pro Val Gly His Met Pro Tyr Gly Trp Leu Thr Glu Ile Arg
             260                 265                 270        
 Ala Val Tyr Pro Ala Phe Asp Lys Asn Asn Pro Ser Asn Lys Leu Val
         275                 280                 285            
 Ser Thr Ser Asn Thr Val Thr Ala Ala His Ile Lys Lys Phe Thr Phe
     290                 295                 300                
 Val Cys Met Ala Leu Ser Leu Thr Leu Cys Phe Val Met Phe Trp Thr
 305                 310                 315                 320
 Pro Asn Val Ser Glu Lys Ile Leu Ile Asp Ile Ile Gly Val Asp Phe
                 325                 330                 335    
 Ala Phe Ala Glu Leu Cys Val Val Pro Leu Arg Ile Phe Ser Phe Phe
             340                 345                 350        
 Pro Val Pro Val Thr Val Arg Ala His Leu Thr Gly Trp Leu Met Thr
         355                 360                 365            
 Leu Lys Lys Thr Phe Val Leu Ala Pro Ser Ser Val Leu Arg Ile Ile
     370                 375                 380                
 Val Leu Ile Ala Ser Leu Val Val Leu Pro Tyr Leu Gly Val His Gly
 385                 390                 395                 400
 Ala Thr Leu Gly Val Gly Ser Leu Leu Ala Gly Phe Val Gly Glu Ser
                 405                 410                 415    
 Thr Met Asp Ala Ile Ala Ala Cys Tyr Val Tyr Arg Lys Gln Lys Lys
             420                 425                 430        
 Lys Met Glu Asn Glu Ser Ala Thr Glu Gly Glu Asp Ser Ala Met Thr
         435                 440                 445            
 Asp Met Pro Pro Thr Glu Glu Val Thr Asp Ile Val Glu Met Arg Glu
     450                 455                 460                
 Glu Asn Glu
 465        



      <210> 2953
      <211> 775
      <212> PRT
      <213> Homo sapiens


      <400> 2953
 Met Leu Phe Ile Val Thr Ala Leu Leu Cys Cys Gly Leu Cys Asn Gly
   1               5                  10                  15    
 Val Leu Ile Glu Glu Thr Glu Ile Val Met Pro Thr Pro Lys Pro Glu
              20                  25                  30        
 Leu Trp Ala Glu Thr Asn Phe Pro Leu Ala Pro Trp Lys Asn Leu Thr
          35                  40                  45            
 Leu Trp Cys Arg Ser Pro Ser Gly Ser Thr Lys Glu Phe Val Leu Leu
      50                  55                  60                
 Lys Asp Gly Thr Gly Trp Ile Ala Thr Arg Pro Ala Ser Glu Gln Val
  65                  70                  75                  80
 Arg Ala Ala Phe Pro Leu Gly Ala Leu Thr Gln Ser His Thr Gly Ser
                  85                  90                  95    
 Tyr His Cys His Ser Trp Glu Glu Met Ala Val Ser Glu Pro Ser Glu
             100                 105                 110        
 Ala Leu Glu Leu Val Gly Thr Asp Ile Leu Pro Lys Pro Val Ile Ser
         115                 120                 125            
 Ala Ser Pro Thr Ile Arg Gly Gln Glu Leu Gln Leu Arg Cys Lys Gly
     130                 135                 140                
 Trp Leu Ala Gly Met Gly Phe Ala Leu Tyr Lys Glu Gly Glu Gln Glu
 145                 150                 155                 160
 Pro Val Gln Gln Leu Gly Ala Val Gly Arg Glu Ala Phe Phe Thr Ile
                 165                 170                 175    
 Gln Arg Met Glu Asp Lys Asp Glu Gly Asn Tyr Ser Cys Arg Thr His
             180                 185                 190        
 Thr Glu Lys Arg Pro Phe Lys Trp Ser Glu Pro Ser Glu Pro Leu Glu
         195                 200                 205            
 Leu Val Ile Lys Glu Met Tyr Pro Lys Pro Phe Phe Lys Thr Trp Ala
     210                 215                 220                
 Ser Pro Val Val Thr Pro Gly Ala Arg Val Thr Phe Asn Cys Ser Thr
 225                 230                 235                 240
 Pro His Gln His Met Ser Phe Ile Leu Tyr Lys Asp Gly Ser Glu Ile
                 245                 250                 255    
 Ala Ser Ser Asp Arg Ser Trp Ala Ser Pro Gly Ala Ser Ala Ala His
             260                 265                 270        
 Phe Leu Ile Ile Ser Val Gly Ile Gly Asp Gly Gly Asn Tyr Ser Cys
         275                 280                 285            
 Arg Tyr Tyr Asp Phe Ser Ile Trp Ser Glu Pro Ser Asp Pro Val Glu
     290                 295                 300                
 Leu Val Val Thr Glu Phe Tyr Pro Lys Pro Thr Leu Leu Ala Gln Pro
 305                 310                 315                 320
 Gly Pro Val Val Phe Pro Gly Lys Ser Val Ile Leu Arg Cys Gln Gly
                 325                 330                 335    
 Thr Phe Gln Gly Met Arg Phe Ala Leu Leu Gln Glu Gly Ala His Val
             340                 345                 350        
 Pro Leu Gln Phe Arg Ser Val Ser Gly Asn Ser Ala Asp Phe Leu Leu
         355                 360                 365            
 His Thr Val Gly Ala Glu Asp Ser Gly Asn Tyr Ser Cys Ile Tyr Tyr
     370                 375                 380                
 Glu Thr Thr Met Ser Asn Arg Gly Ser Tyr Leu Ser Met Pro Leu Met
 385                 390                 395                 400
 Ile Trp Val Thr Asp Thr Phe Pro Lys Pro Trp Leu Phe Ala Glu Pro
                 405                 410                 415    
 Ser Ser Val Val Pro Met Gly Gln Asn Val Thr Leu Trp Cys Arg Gly
             420                 425                 430        
 Pro Val His Gly Val Gly Tyr Ile Leu His Lys Glu Gly Glu Ala Thr
         435                 440                 445            
 Ser Met Gln Leu Trp Gly Ser Thr Ser Asn Asp Gly Ala Phe Pro Ile
     450                 455                 460                
 Thr Asn Ile Ser Gly Thr Ser Met Gly Arg Tyr Ser Cys Cys Tyr His
 465                 470                 475                 480
 Pro Asp Trp Thr Ser Ser Ile Lys Ile Gln Pro Ser Asn Thr Leu Glu
                 485                 490                 495    
 Leu Leu Val Thr Gly Leu Leu Pro Lys Pro Ser Leu Leu Ala Gln Pro
             500                 505                 510        
 Gly Pro Met Val Ala Pro Gly Glu Asn Met Thr Leu Gln Cys Gln Gly
         515                 520                 525            
 Glu Leu Pro Asp Ser Thr Phe Val Leu Leu Lys Glu Gly Ala Gln Glu
     530                 535                 540                
 Pro Leu Glu Gln Gln Arg Pro Ser Gly Tyr Arg Ala Asp Phe Trp Met
 545                 550                 555                 560
 Pro Ala Val Arg Gly Glu Asp Ser Gly Ile Tyr Ser Cys Val Tyr Tyr
                 565                 570                 575    
 Leu Asp Ser Thr Pro Phe Ala Ala Ser Asn His Ser Asp Ser Leu Glu
             580                 585                 590        
 Ile Trp Val Thr Asp Lys Pro Pro Lys Pro Ser Leu Ser Ala Trp Pro
         595                 600                 605            
 Ser Thr Met Phe Lys Leu Gly Lys Asp Ile Thr Leu Gln Cys Arg Gly
     610                 615                 620                
 Pro Leu Pro Gly Val Glu Phe Val Leu Glu His Asp Gly Glu Glu Ala
 625                 630                 635                 640
 Pro Gln Gln Phe Ser Glu Asp Gly Asp Phe Val Ile Asn Asn Val Glu
                 645                 650                 655    
 Gly Lys Gly Ile Gly Asn Tyr Ser Cys Ser Tyr Arg Leu Gln Ala Tyr
             660                 665                 670        
 Pro Asp Ile Trp Ser Glu Pro Ser Asp Pro Leu Glu Leu Val Gly Ala
         675                 680                 685            
 Ala Gly Pro Val Ala Gln Glu Cys Thr Val Gly Asn Ile Val Arg Ser
     690                 695                 700                
 Ser Leu Ile Val Val Val Val Val Ala Leu Gly Val Val Leu Ala Ile
 705                 710                 715                 720
 Glu Trp Lys Lys Trp Pro Arg Leu Arg Thr Arg Gly Ser Glu Thr Asp
                 725                 730                 735    
 Gly Arg Asp Gln Thr Ile Ala Leu Glu Glu Cys Asn Gln Glu Gly Glu
             740                 745                 750        
 Pro Gly Thr Pro Ala Asn Ser Pro Ser Ser Thr Ser Gln Arg Ile Ser
         755                 760                 765            
 Val Glu Leu Pro Val Pro Ile
     770                 775



      <210> 2954
      <211> 2204
      <212> PRT
      <213> Homo sapiens

      <220>
      <221> misc_feature
      <222> (1)...(2204)
      <223> Xaa = any amino acid or symbol as shown in the table 8 as set forth in Example 2


      <400> 2954
 Pro Arg Ser Leu Cys Phe Ser Leu Trp Ala Glu Ala Ala Val Leu Ala
   1               5                  10                  15    
 Asp Gly Gly Leu Arg Arg Arg Arg Arg Leu Leu Arg Gly Thr Met Ser
              20                  25                  30        
 Ala Ser Phe Val Pro Asn Gly Ala Ser Leu Glu Asp Cys His Cys Asn
          35                  40                  45            
 Leu Phe Cys Leu Ala Asp Leu Thr Gly Ile Lys Trp Lys Lys Tyr Val
      50                  55                  60                
 Trp Gln Gly Pro Thr Ser Ala Pro Ile Leu Phe Pro Val Thr Glu Glu
  65                  70                  75                  80
 Asp Pro Ile Leu Ser Ser Phe Ser Arg Cys Leu Lys Ala Asp Val Leu
                  85                  90                  95    
 Gly Val Trp Arg Arg Asp Gln Arg Pro Glu Arg Arg Glu Leu Xaa Ile
             100                 105                 110        
 Phe Trp Gly Gly Glu Asp Pro Val Leu Leu Thr Leu Phe Thr Met Thr
         115                 120                 125            
 Tyr Gln Lys Lys Lys Met Glu Cys Gly Arg Met Asp Phe Pro Met Asn
     130                 135                 140                
 Ala Val Leu Cys Phe Ser Lys Ala Val His Asn Leu Leu Glu Arg Cys
 145                 150                 155                 160
 Leu Met Asn Arg Asn Phe Val Arg Ile Gly Lys Trp Phe Val Lys Pro
                 165                 170                 175    
 Tyr Glu Lys Asp Glu Lys Pro Ile Asn Lys Ser Glu His Leu Ser Cys
             180                 185                 190        
 Ser Phe Thr Phe Phe Leu His Gly Asp Ser Asn Val Cys Thr Ser Val
         195                 200                 205            
 Glu Ile Asn Gln His Gln Pro Val Tyr Leu Leu Ser Glu Glu His Ile
     210                 215                 220                
 Thr Leu Ala Gln Gln Ser Asn Ser Pro Phe Gln Val Ile Leu Cys Pro
 225                 230                 235                 240
 Phe Gly Leu Asn Gly Thr Leu Thr Gly Gln Ala Phe Lys Met Ser Asp
                 245                 250                 255    
 Ser Ala Thr Lys Lys Leu Ile Gly Glu Trp Lys Gln Phe Tyr Pro Ile
             260                 265                 270        
 Ser Cys Cys Leu Lys Glu Met Ser Glu Glu Lys Gln Glu Asp Met Asp
         275                 280                 285            
 Trp Glu Asp Asp Ser Leu Ala Ala Val Glu Val Leu Val Ala Gly Val
     290                 295                 300                
 Arg Met Ile Tyr Pro Ala Cys Phe Val Leu Val Pro Gln Ser Asp Ile
 305                 310                 315                 320
 Pro Thr Pro Ser Pro Val Gly Ser Thr His Cys Ser Ser Ser Cys Leu
                 325                 330                 335    
 Gly Val His Gln Val Pro Ala Ser Thr Arg Asp Pro Ala Met Ser Ser
             340                 345                 350        
 Val Thr Leu Thr Pro Pro Thr Ser Pro Glu Glu Val Gln Thr Val Asp
         355                 360                 365            
 Pro Gln Ser Val Gln Lys Trp Val Lys Phe Ser Ser Val Ser Asp Gly
     370                 375                 380                
 Phe Asn Ser Asp Ser Thr Ser His His Gly Gly Lys Ile Pro Arg Lys
 385                 390                 395                 400
 Leu Ala Asn His Val Val Asp Arg Val Trp Gln Glu Cys Asn Met Asn
                 405                 410                 415    
 Arg Ala Gln Asn Lys Arg Lys Tyr Ser Ala Ser Ser Gly Gly Leu Cys
             420                 425                 430        
 Glu Glu Ala Thr Ala Ala Lys Val Ala Ser Trp Asp Phe Val Glu Ala
         435                 440                 445            
 Thr Gln Arg Thr Asn Cys Ser Cys Leu Arg His Lys Asn Leu Lys Ser
     450                 455                 460                
 Arg Asn Ala Gly Gln Gln Gly Gln Ala Pro Ser Leu Gly Gln Gln Gln
 465                 470                 475                 480
 Gln Ile Leu Pro Lys His Lys Thr Asn Glu Lys Gln Glu Lys Ser Glu
                 485                 490                 495    
 Lys Pro Gln Lys Arg Pro Leu Thr Pro Phe His His Arg Val Ser Val
             500                 505                 510        
 Ser Asp Asp Val Gly Met Asp Ala Asp Ser Ala Ser Gln Arg Leu Val
         515                 520                 525            
 Ile Ser Ala Pro Asp Ser Gln Val Arg Phe Ser Asn Ile Arg Thr Asn
     530                 535                 540                
 Asp Val Ala Lys Thr Pro Gln Met His Gly Thr Glu Met Ala Asn Ser
 545                 550                 555                 560
 Pro Gln Pro Pro Pro Leu Ser Pro His Pro Cys Asp Val Val Asp Glu
                 565                 570                 575    
 Gly Val Thr Lys Thr Pro Ser Thr Pro Gln Ser Gln His Phe Tyr Gln
             580                 585                 590        
 Met Pro Thr Pro Asp Pro Leu Val Pro Ser Lys Pro Met Glu Asp Arg
         595                 600                 605            
 Ile Asp Ser Leu Ser Gln Ser Phe Pro Pro Gln Tyr Gln Glu Ala Val
     610                 615                 620                
 Glu Pro Thr Val Tyr Val Gly Thr Ala Val Asn Leu Glu Glu Asp Glu
 625                 630                 635                 640
 Ala Asn Ile Ala Trp Lys Tyr Tyr Lys Phe Pro Lys Lys Lys Asp Val
                 645                 650                 655    
 Glu Phe Leu Pro Pro Gln Leu Pro Ser Asp Lys Phe Lys Asp Asp Pro
             660                 665                 670        
 Val Gly Pro Phe Gly Gln Glu Ser Val Thr Ser Val Thr Glu Leu Met
         675                 680                 685            
 Val Gln Cys Lys Lys Pro Leu Lys Val Ser Asp Glu Leu Val Gln Gln
     690                 695                 700                
 Tyr Gln Ile Lys Asn Gln Cys Leu Ser Ala Ile Ala Ser Asp Ala Glu
 705                 710                 715                 720
 Gln Glu Pro Lys Ile Asp Pro Tyr Ala Phe Val Glu Gly Asp Glu Glu
                 725                 730                 735    
 Phe Leu Phe Pro Asp Lys Lys Asp Arg Gln Asn Ser Glu Arg Glu Ala
             740                 745                 750        
 Gly Lys Lys His Lys Val Glu Asp Gly Thr Ser Ser Val Thr Val Leu
         755                 760                 765            
 Ser His Glu Glu Asp Ala Met Ser Leu Phe Ser Pro Ser Ile Lys Gln
     770                 775                 780                
 Asp Ala Pro Arg Pro Thr Ser His Ala Arg Pro Pro Ser Thr Ser Leu
 785                 790                 795                 800
 Ile Tyr Asp Ser Asp Leu Ala Val Ser Tyr Thr Asp Leu Asp Asn Leu
                 805                 810                 815    
 Phe Asn Ser Asp Glu Asp Glu Leu Thr Pro Gly Ser Lys Arg Ser Ala
             820                 825                 830        
 Asn Gly Ser Asp Asp Lys Ala Ser Cys Lys Glu Ser Lys Thr Gly Asn
         835                 840                 845            
 Leu Asp Pro Leu Ser Cys Ile Ser Thr Ala Asp Leu His Lys Met Tyr
     850                 855                 860                
 Pro Thr Pro Pro Ser Leu Glu Gln His Ile Met Gly Phe Ser Pro Met
 865                 870                 875                 880
 Asn Met Asn Asn Lys Glu Tyr Gly Ser Met Asp Thr Thr Pro Gly Gly
                 885                 890                 895    
 Thr Val Leu Glu Gly Asn Ser Ser Ser Ile Gly Ala Gln Phe Lys Ile
             900                 905                 910        
 Glu Val Asp Glu Gly Phe Cys Ser Pro Lys Pro Ser Glu Ile Lys Asp
         915                 920                 925            
 Phe Ser Tyr Val Tyr Lys Pro Glu Asn Cys Gln Ile Leu Val Gly Cys
     930                 935                 940                
 Ser Met Phe Ala Pro Leu Lys Thr Leu Pro Ser Gln Tyr Leu Pro Leu
 945                 950                 955                 960
 Ile Lys Leu Pro Glu Glu Cys Ile Tyr Arg Gln Ser Trp Thr Val Gly
                 965                 970                 975    
 Lys Leu Glu Leu Leu Ser Ser Gly Pro Ser Met Pro Phe Ile Lys Glu
             980                 985                 990        
 Gly Asp Gly Ser Asn Met Asp Gln Glu Tyr Gly Thr Ala Tyr Thr Pro
         995                1000                1005            
 Gln Thr His Thr Ser Cys Gly Met Pro Pro Ser Ser Ala Pro Pro Ser
    1010                1015                1020                
 Asn Ser Gly Ala Gly Ile Leu Pro Ser Pro Ser Thr Pro Arg Phe Pro
1025                1030                1035                1040
 Thr Pro Arg Thr Pro Arg Thr Pro Arg Thr Pro Arg Gly Ala Gly Gly
                1045                1050                1055    
 Pro Ala Ser Ala Gln Gly Ser Val Lys Tyr Glu Asn Ser Asp Leu Tyr
            1060                1065                1070        
 Ser Pro Ala Ser Thr Pro Ser Thr Cys Arg Pro Leu Asn Ser Val Glu
        1075                1080                1085            
 Pro Ala Thr Val Pro Ser Ile Pro Glu Ala His Ser Leu Tyr Val Asn
    1090                1095                1100                
 Leu Ile Leu Ser Glu Ser Val Met Asn Leu Phe Lys Asp Cys Asn Ser
1105                1110                1115                1120
 Asp Ser Cys Cys Ile Cys Val Cys Asn Met Asn Ile Lys Gly Ala Asp
                1125                1130                1135    
 Val Gly Val Tyr Ile Pro Asp Pro Thr Gln Glu Ala Gln Tyr Arg Cys
            1140                1145                1150        
 Thr Cys Gly Phe Ser Ala Val Met Asn Arg Lys Phe Gly Asn Asn Ser
        1155                1160                1165            
 Gly Leu Phe Phe Glu Asp Glu Leu Asp Ile Ile Gly Arg Asn Thr Asp
    1170                1175                1180                
 Cys Gly Lys Glu Ala Glu Lys Arg Phe Glu Ala Leu Arg Ala Thr Ser
1185                1190                1195                1200
 Ala Glu His Val Asn Gly Gly Leu Lys Glu Ser Glu Lys Leu Ser Asp
                1205                1210                1215    
 Asp Leu Ile Leu Leu Leu Gln Asp Gln Cys Thr Asn Leu Phe Ser Pro
            1220                1225                1230        
 Phe Gly Ala Ala Asp Gln Asp Pro Phe Pro Lys Ser Gly Val Ile Ser
        1235                1240                1245            
 Asn Trp Val Arg Val Glu Glu Arg Asp Cys Cys Asn Asp Cys Tyr Leu
    1250                1255                1260                
 Ala Leu Glu His Gly Arg Gln Phe Met Asp Asn Met Ser Gly Gly Lys
1265                1270                1275                1280
 Val Asp Glu Ala Leu Val Lys Ser Ser Cys Leu His Pro Trp Ser Lys
                1285                1290                1295    
 Arg Asn Asp Val Ser Met Gln Cys Ser Gln Asp Ile Leu Arg Met Leu
            1300                1305                1310        
 Leu Ser Leu Gln Pro Val Leu Gln Asp Ala Ile Gln Lys Lys Arg Thr
        1315                1320                1325            
 Val Arg Pro Trp Gly Val Gln Gly Pro Leu Thr Trp Gln Gln Phe His
    1330                1335                1340                
 Lys Met Ala Gly Arg Gly Ser Tyr Gly Thr Asp Glu Ser Pro Glu Pro
1345                1350                1355                1360
 Leu Pro Ile Pro Thr Phe Leu Leu Gly Tyr Asp Tyr Asp Tyr Leu Val
                1365                1370                1375    
 Leu Ser Pro Phe Ala Leu Pro Tyr Trp Glu Arg Leu Met Leu Glu Pro
            1380                1385                1390        
 Tyr Gly Ser Gln Arg Asp Ile Ala Tyr Val Val Leu Cys Pro Glu Asn
        1395                1400                1405            
 Glu Ala Leu Leu Asn Gly Ala Lys Ser Phe Phe Arg Asp Leu Thr Ala
    1410                1415                1420                
 Ile Tyr Glu Ser Cys Arg Leu Gly Gln His Arg Pro Val Ser Arg Leu
1425                1430                1435                1440
 Leu Thr Asp Gly Ile Met Arg Val Gly Ser Thr Ala Ser Lys Lys Leu
                1445                1450                1455    
 Ser Glu Lys Leu Val Ala Glu Trp Phe Ser Gln Ala Ala Asp Gly Asn
            1460                1465                1470        
 Asn Glu Ala Phe Ser Lys Leu Lys Leu Tyr Ala Gln Val Cys Arg Tyr
        1475                1480                1485            
 Asp Leu Gly Pro Tyr Leu Ala Ser Leu Pro Leu Asp Ser Ser Leu Leu
    1490                1495                1500                
 Ser Gln Pro Asn Leu Val Ala Pro Thr Ser Gln Ser Leu Ile Thr Pro
1505                1510                1515                1520
 Pro Gln Met Thr Asn Thr Gly Asn Ala Asn Thr Pro Ser Ala Thr Leu
                1525                1530                1535    
 Ala Ser Ala Ala Ser Ser Thr Met Thr Val Thr Ser Gly Val Ala Ile
            1540                1545                1550        
 Ser Thr Ser Val Ala Thr Ala Asn Ser Thr Leu Thr Thr Ala Ser Thr
        1555                1560                1565            
 Ser Ser Ser Ser Ser Ser Asn Leu Asn Ser Gly Val Ser Ser Asn Lys
    1570                1575                1580                
 Leu Pro Ser Phe Pro Pro Phe Gly Ser Met Asn Ser Asn Ala Ala Gly
1585                1590                1595                1600
 Ser Met Ser Thr Gln Ala Asn Thr Val Gln Ser Gly Gln Leu Gly Gly
                1605                1610                1615    
 Gln Gln Thr Ser Ala Leu Gln Thr Ala Gly Ile Ser Gly Glu Ser Ser
            1620                1625                1630        
 Ser Leu Pro Thr Gln Pro His Pro Asp Val Ser Glu Ser Thr Met Asp
        1635                1640                1645            
 Arg Asp Lys Val Gly Ile Pro Thr Asp Gly Asp Ser His Ala Val Thr
    1650                1655                1660                
 Tyr Pro Pro Ala Ile Val Val Tyr Ile Ile Asp Pro Phe Thr Tyr Glu
1665                1670                1675                1680
 Asn Thr Asp Glu Ser Thr Asn Ser Ser Ser Val Trp Thr Leu Gly Leu
                1685                1690                1695    
 Leu Arg Cys Phe Leu Glu Met Val Gln Thr Leu Pro Pro His Ile Lys
            1700                1705                1710        
 Ser Thr Val Ser Val Gln Ile Ile Pro Cys Gln Tyr Leu Leu Gln Pro
        1715                1720                1725            
 Val Lys His Glu Asp Arg Glu Ile Tyr Pro Gln His Leu Lys Ser Leu
    1730                1735                1740                
 Ala Phe Ser Ala Phe Thr Gln Cys Arg Arg Pro Leu Pro Thr Ser Thr
1745                1750                1755                1760
 Asn Val Lys Thr Leu Thr Gly Phe Gly Pro Gly Leu Ala Met Glu Thr
                1765                1770                1775    
 Ala Leu Arg Ser Pro Asp Arg Pro Glu Cys Ile Arg Leu Tyr Ala Pro
            1780                1785                1790        
 Pro Phe Ile Leu Ala Pro Val Lys Asp Lys Gln Thr Glu Leu Gly Glu
        1795                1800                1805            
 Thr Phe Gly Glu Ala Gly Gln Lys Tyr Asn Val Leu Phe Val Gly Tyr
    1810                1815                1820                
 Cys Leu Ser His Asp Gln Arg Trp Ile Leu Ala Ser Cys Thr Asp Leu
1825                1830                1835                1840
 Tyr Gly Glu Leu Leu Glu Thr Cys Ile Ile Asn Ile Asp Val Pro Asn
                1845                1850                1855    
 Arg Ala Arg Arg Lys Lys Ser Ser Ala Arg Lys Phe Gly Leu Gln Lys
            1860                1865                1870        
 Leu Trp Glu Trp Cys Leu Gly Leu Val Gln Met Ser Ser Leu Pro Trp
        1875                1880                1885            
 Arg Val Val Ile Gly Arg Leu Gly Arg Ile Gly His Gly Glu Leu Lys
    1890                1895                1900                
 Asp Trp Ser Cys Leu Leu Ser Arg Arg Asn Leu Gln Ser Leu Ser Lys
1905                1910                1915                1920
 Arg Leu Lys Asp Met Cys Arg Met Cys Gly Ile Ser Ala Ala Asp Ser
                1925                1930                1935    
 Pro Ser Ile Leu Ser Ala Cys Leu Val Ala Met Glu Pro Gln Gly Ser
            1940                1945                1950        
 Phe Val Ile Met Pro Asp Ser Val Ser Thr Gly Ser Val Phe Gly Arg
        1955                1960                1965            
 Ser Thr Thr Leu Asn Met Gln Thr Ser Gln Leu Asn Thr Pro Gln Asp
    1970                1975                1980                
 Thr Ser Cys Thr His Ile Leu Val Phe Pro Thr Ser Ala Ser Val Gln
1985                1990                1995                2000
 Val Ala Ser Ala Thr Tyr Thr Thr Glu Asn Leu Asp Leu Ala Phe Asn
                2005                2010                2015    
 Pro Asn Asn Asp Gly Ala Asp Gly Met Gly Ile Phe Asp Leu Leu Asp
            2020                2025                2030        
 Thr Gly Asp Asp Leu Asp Pro Asp Ile Ile Asn Ile Leu Pro Ala Ser
        2035                2040                2045            
 Pro Thr Gly Ser Pro Val His Ser Pro Gly Ser His Tyr Pro His Gly
    2050                2055                2060                
 Gly Asp Ala Gly Lys Gly Gln Ser Thr Asp Arg Leu Leu Ser Thr Glu
2065                2070                2075                2080
 Pro His Glu Glu Val Pro Asn Ile Leu Gln Gln Pro Leu Ala Leu Gly
                2085                2090                2095    
 Tyr Phe Val Ser Thr Ala Lys Ala Gly Pro Leu Pro Asp Trp Phe Trp
            2100                2105                2110        
 Ser Ala Cys Pro Gln Ala Gln Tyr Gln Cys Pro Leu Phe Leu Lys Ala
        2115                2120                2125            
 Ser Leu His Leu His Val Pro Ser Val Gln Ser Asp Glu Leu Leu His
    2130                2135                2140                
 Ser Lys His Ser His Pro Leu Asp Ser Asn Gln Thr Ser Asp Val Leu
2145                2150                2155                2160
 Arg Phe Val Leu Glu Gln Tyr Asn Ala Leu Ser Trp Leu Thr Cys Asp
                2165                2170                2175    
 Pro Ala Thr Gln Asp Arg Arg Ser Cys Leu Pro Ile His Phe Val Val
            2180                2185                2190        
 Leu Asn Gln Leu Tyr Asn Phe Ile Met Asn Met Leu
        2195                2200                



      <210> 2955
      <211> 60
      <212> PRT
      <213> Homo sapiens


      <400> 2955
 Asn Thr Gly Lys Pro Asn Pro Ala Ala His Gln Lys Ala Tyr Pro Pro
   1               5                  10                  15    
 Pro Ser Ser Trp Leu His Pro Trp Asp Ala Arg Leu Val Gln His Thr
              20                  25                  30        
 Gln Ile Asn Lys Arg Asn Pro Ser Tyr Lys Gln Asn Gln Arg Gln Lys
          35                  40                  45            
 Pro His Asp Tyr Leu Asn Arg Ser Arg Lys Gly Leu
      50                  55                  60



      <210> 2956
      <211> 193
      <212> PRT
      <213> Homo sapiens


      <400> 2956
 Gly Cys Leu Pro Leu Ser Arg His Pro Pro His Leu Asp Pro Ser Gln
   1               5                  10                  15    
 Tyr Ser Phe Ser His Pro Val Pro His Val Cys Cys Ser Pro Val Ala
              20                  25                  30        
 Cys Val Thr Cys Ala Cys Ser Leu Gln Leu Leu Lys Phe Ile Pro Glu
          35                  40                  45            
 Lys Ser Asp Ile Asp Leu Leu Glu Glu His Lys His Glu Ile Glu Arg
      50                  55                  60                
 Met Ala Arg Ala Asp Arg Phe Leu Tyr Glu Met Ser Arg Leu Gly His
  65                  70                  75                  80
 Gly His Gly Gly Asp Ser Ser Arg Trp Gly Ser Gly Arg Trp Gly Arg
                  85                  90                  95    
 Trp Gly Ser Ala Lys Arg Lys Gly Met Glu Val Gly Arg Leu Glu Arg
             100                 105                 110        
 Arg Leu Glu Leu Ala Pro Gly Ala Gly Ala Gly Gln Asp Arg Gly Gly
         115                 120                 125            
 Ile Pro Gln Tyr Met Val His Leu Val Tyr Arg Ile Asp His Tyr Gln
     130                 135                 140                
 Gln Arg Leu Gln Ala Leu Phe Phe Lys Lys Lys Phe Gln Glu Arg Leu
 145                 150                 155                 160
 Ala Glu Ala Lys Pro Lys Val Glu Gly Arg Ala Glu Gly Cys Arg Arg
                 165                 170                 175    
 Leu Arg Val Gln Thr Tyr Leu Arg Lys Ala Ala Trp Leu Gly Ala Ser
             180                 185                 190        
 Glu
    



      <210> 2957
      <211> 10
      <212> PRT
      <213> Homo sapiens


      <400> 2957
 Glu His Ala Pro His Cys Glu Pro Cys Met
   1               5                  10



      <210> 2958
      <211> 1842
      <212> PRT
      <213> Homo sapiens


      <400> 2958
 Leu Pro His Gly Arg Thr Arg Gly Pro Gly Pro Ala Met Ala Pro Trp
   1               5                  10                  15    
 Arg Lys Ala Asp Lys Glu Arg His Gly Val Ala Ile Tyr Asn Phe Gln
              20                  25                  30        
 Gly Ser Gly Ala Pro Gln Leu Ser Leu Gln Ile Gly Asp Val Val Arg
          35                  40                  45            
 Ile Gln Glu Thr Cys Gly Asp Trp Tyr Arg Gly Tyr Leu Ile Lys His
      50                  55                  60                
 Lys Met Leu Gln Gly Ile Phe Pro Lys Ser Phe Ile His Ile Lys Glu
  65                  70                  75                  80
 Val Thr Val Glu Lys Arg Arg Asn Thr Glu Asn Ile Ile Pro Ala Glu
                  85                  90                  95    
 Ile Pro Leu Ala Gln Glu Val Thr Thr Thr Leu Trp Glu Trp Gly Ser
             100                 105                 110        
 Ile Trp Lys Gln Leu Tyr Val Ala Ser Lys Lys Glu Arg Phe Leu Gln
         115                 120                 125            
 Val Gln Ser Met Met Tyr Asp Leu Met Glu Trp Arg Ser Gln Leu Leu
     130                 135                 140                
 Ser Gly Thr Leu Pro Lys Asp Glu Leu Lys Glu Leu Lys Gln Lys Val
 145                 150                 155                 160
 Thr Ser Lys Ile Asp Tyr Gly Asn Lys Ile Leu Glu Leu Asp Leu Ile
                 165                 170                 175    
 Val Arg Asp Glu Asp Gly Asn Ile Leu Asp Pro Asp Asn Thr Ser Val
             180                 185                 190        
 Ile Ser Leu Phe His Ala His Glu Glu Ala Thr Asp Lys Ile Thr Glu
         195                 200                 205            
 Arg Ile Lys Glu Glu Met Ser Lys Asp Gln Pro Asp Tyr Ala Met Tyr
     210                 215                 220                
 Ser Arg Ile Ser Ser Ser Pro Thr His Ser Leu Tyr Val Phe Val Arg
 225                 230                 235                 240
 Asn Phe Val Cys Arg Ile Gly Glu Asp Ala Glu Leu Phe Met Ser Leu
                 245                 250                 255    
 Tyr Asp Pro Asn Lys Gln Thr Val Ile Ser Glu Asn Tyr Leu Val Arg
             260                 265                 270        
 Trp Gly Ser Arg Gly Phe Pro Lys Glu Ile Glu Met Leu Asn Asn Leu
         275                 280                 285            
 Lys Val Val Phe Thr Asp Leu Gly Asn Lys Asp Leu Asn Arg Asp Lys
     290                 295                 300                
 Ile Tyr Leu Ile Cys Gln Ile Val Arg Val Gly Lys Met Asp Leu Lys
 305                 310                 315                 320
 Asp Thr Gly Ala Lys Lys Cys Thr Gln Gly Leu Arg Arg Pro Phe Gly
                 325                 330                 335    
 Val Ala Val Met Asp Ile Thr Asp Ile Ile Lys Gly Lys Ala Glu Ser
             340                 345                 350        
 Asp Glu Glu Lys Gln His Phe Ile Pro Phe His Pro Val Thr Ala Glu
         355                 360                 365            
 Asn Asp Phe Leu His Ser Leu Leu Gly Lys Val Ile Ala Ser Lys Gly
     370                 375                 380                
 Asp Ser Gly Gly Gln Gly Leu Trp Val Thr Met Lys Met Leu Val Gly
 385                 390                 395                 400
 Asp Ile Ile Gln Ile Arg Lys Asp Tyr Pro His Leu Val Asp Arg Thr
                 405                 410                 415    
 Thr Val Val Ala Arg Lys Leu Gly Phe Pro Glu Ile Ile Met Pro Gly
             420                 425                 430        
 Asp Val Arg Asn Asp Ile Tyr Ile Thr Leu Leu Gln Gly Asp Phe Asp
         435                 440                 445            
 Lys Tyr Asn Lys Thr Thr Gln Arg Asn Val Glu Val Ile Met Cys Val
     450                 455                 460                
 Cys Ala Glu Asp Gly Lys Thr Leu Pro Asn Ala Ile Cys Val Gly Ala
 465                 470                 475                 480
 Gly Asp Lys Pro Met Asn Glu Tyr Arg Ser Val Val Tyr Tyr Gln Val
                 485                 490                 495    
 Lys Gln Pro Arg Trp Met Glu Thr Val Lys Val Ala Val Pro Ile Glu
             500                 505                 510        
 Asp Met Gln Arg Ile His Leu Arg Phe Met Phe Arg His Arg Ser Ser
         515                 520                 525            
 Leu Glu Ser Lys Asp Lys Gly Glu Lys Asn Phe Ala Met Ser Tyr Val
     530                 535                 540                
 Lys Leu Met Lys Glu Asp Gly Thr Thr Leu His Asp Gly Phe His Asp
 545                 550                 555                 560
 Leu Val Val Leu Lys Gly Asp Ser Lys Lys Met Glu Asp Ala Ser Ala
                 565                 570                 575    
 Tyr Leu Thr Leu Pro Ser Tyr Arg His His Val Glu Asn Lys Gly Ala
             580                 585                 590        
 Thr Leu Ser Arg Ser Ser Ser Ser Val Gly Gly Leu Ser Val Ser Ser
         595                 600                 605            
 Arg Asp Val Phe Ser Ile Ser Thr Leu Val Cys Ser Thr Lys Leu Thr
     610                 615                 620                
 Gln Asn Val Gly Leu Leu Gly Leu Leu Lys Trp Arg Met Lys Pro Gln
 625                 630                 635                 640
 Leu Leu Gln Glu Asn Leu Glu Lys Leu Lys Ile Val Asp Gly Glu Glu
                 645                 650                 655    
 Val Val Lys Phe Leu Gln Asp Thr Leu Asp Ala Leu Phe Asn Ile Met
             660                 665                 670        
 Met Glu His Ser Gln Ser Asp Glu Tyr Asp Ile Leu Val Phe Asp Ala
         675                 680                 685            
 Leu Ile Tyr Ile Ile Gly Leu Ile Ala Asp Arg Lys Phe Gln His Phe
     690                 695                 700                
 Asn Thr Val Leu Glu Ala Tyr Ile Gln Gln His Phe Ser Ala Thr Leu
 705                 710                 715                 720
 Ala Tyr Lys Lys Leu Met Thr Val Leu Lys Thr Tyr Leu Asp Thr Ser
                 725                 730                 735    
 Ser Arg Gly Glu Gln Cys Glu Pro Ile Leu Arg Thr Leu Lys Ala Leu
             740                 745                 750        
 Glu Tyr Val Phe Lys Phe Ile Val Arg Ser Arg Thr Leu Phe Ser Gln
         755                 760                 765            
 Leu Tyr Glu Gly Lys Glu Gln Met Glu Phe Glu Glu Ser Met Arg Arg
     770                 775                 780                
 Leu Phe Glu Ser Ile Asn Asn Leu Met Lys Ser Gln Tyr Lys Thr Thr
 785                 790                 795                 800
 Ile Leu Leu Gln Val Ala Ala Leu Lys Tyr Ile Pro Ser Val Leu His
                 805                 810                 815    
 Asp Val Glu Met Val Phe Asp Ala Lys Leu Leu Ser Gln Leu Leu Tyr
             820                 825                 830        
 Glu Phe Tyr Thr Cys Ile Pro Pro Val Lys Leu Gln Lys Gln Lys Val
         835                 840                 845            
 Gln Ser Met Asn Glu Ile Val Gln Ser Asn Leu Phe Lys Lys Gln Glu
     850                 855                 860                
 Cys Arg Asp Ile Leu Leu Pro Val Ile Thr Lys Glu Leu Lys Glu Leu
 865                 870                 875                 880
 Leu Glu Gln Lys Asp Asp Met Gln His Gln Val Leu Glu Arg Lys Tyr
                 885                 890                 895    
 Cys Val Glu Leu Leu Asn Ser Ile Leu Glu Val Leu Ser Tyr Gln Asp
             900                 905                 910        
 Ala Ala Phe Thr Tyr His His Ile Gln Glu Ile Met Val Gln Leu Leu
         915                 920                 925            
 Arg Thr Val Asn Arg Thr Val Ile Thr Met Gly Arg Asp His Ile Leu
     930                 935                 940                
 Ile Ser His Phe Val Ala Cys Met Thr Ala Ile Leu Asn Gln Met Gly
 945                 950                 955                 960
 Asp Gln His Tyr Ser Phe Tyr Ile Glu Thr Phe Gln Thr Ser Ser Glu
                 965                 970                 975    
 Leu Val Asp Phe Leu Met Glu Thr Phe Ile Met Phe Lys Asp Leu Ile
             980                 985                 990        
 Gly Lys Asn Val Tyr Pro Gly Asp Trp Met Ala Met Ser Met Val Gln
         995                1000                1005            
 Asn Arg Val Phe Leu Arg Ala Ile Asn Lys Phe Ala Glu Thr Met Asn
    1010                1015                1020                
 Gln Lys Phe Leu Glu His Thr Asn Phe Glu Phe Gln Leu Trp Asn Asn
1025                1030                1035                1040
 Tyr Phe His Leu Ala Val Ala Phe Ile Thr Gln Asp Ser Leu Gln Leu
                1045                1050                1055    
 Glu Gln Phe Ser His Ala Lys Tyr Asn Lys Ile Leu Asn Lys Tyr Gly
            1060                1065                1070        
 Asp Met Arg Arg Leu Ile Gly Phe Ser Ile Arg Asp Met Trp Tyr Lys
        1075                1080                1085            
 Leu Gly Gln Asn Lys Ile Cys Phe Ile Pro Gly Met Val Gly Pro Ile
    1090                1095                1100                
 Leu Glu Met Thr Leu Ile Pro Glu Ala Glu Leu Arg Lys Ala Thr Ile
1105                1110                1115                1120
 Pro Ile Phe Phe Asp Met Met Leu Cys Glu Tyr Gln Arg Ser Gly Asp
                1125                1130                1135    
 Phe Lys Lys Phe Glu Asn Glu Ile Ile Leu Lys Leu Asp His Glu Val
            1140                1145                1150        
 Glu Gly Gly Arg Gly Asp Glu Gln Tyr Met Gln Leu Leu Glu Ser Ile
        1155                1160                1165            
 Leu Met Glu Cys Ala Ala Glu His Pro Thr Ile Ala Lys Ser Val Glu
    1170                1175                1180                
 Asn Phe Val Asn Leu Val Lys Gly Leu Leu Glu Lys Leu Leu Asp Tyr
1185                1190                1195                1200
 Arg Gly Val Met Thr Asp Glu Ser Lys Asp Asn Arg Met Ser Cys Thr
                1205                1210                1215    
 Val Asn Leu Leu Asn Phe Tyr Lys Asp Asn Asn Arg Glu Glu Met Tyr
            1220                1225                1230        
 Ile Arg Tyr Leu Tyr Lys Leu Arg Asp Leu His Leu Asp Cys Asp Asn
        1235                1240                1245            
 Tyr Thr Glu Ala Ala Tyr Thr Leu Leu Leu His Thr Trp Leu Leu Lys
    1250                1255                1260                
 Trp Ser Asp Glu Gln Cys Ala Ser Gln Val Met Gln Thr Gly Gln Gln
1265                1270                1275                1280
 His Pro Gln Thr His Arg Gln Leu Lys Glu Thr Leu Tyr Glu Thr Ile
                1285                1290                1295    
 Ile Gly Tyr Phe Asp Lys Gly Lys Met Trp Glu Glu Ala Ile Ser Leu
            1300                1305                1310        
 Cys Lys Glu Leu Ala Glu Gln Tyr Glu Met Glu Ile Phe Asp Tyr Glu
        1315                1320                1325            
 Leu Leu Ser Gln Asn Leu Ile Gln Gln Ala Lys Phe Tyr Glu Ser Ile
    1330                1335                1340                
 Met Lys Ile Leu Arg Pro Lys Pro Asp Tyr Phe Ala Val Gly Tyr Tyr
1345                1350                1355                1360
 Gly Gln Gly Phe Pro Ser Phe Leu Arg Asn Lys Val Phe Ile Tyr Arg
                1365                1370                1375    
 Gly Lys Glu Tyr Glu Arg Arg Glu Asp Phe Gln Met Gln Leu Met Thr
            1380                1385                1390        
 Gln Phe Pro Asn Ala Glu Lys Met Asn Thr Thr Ser Ala Pro Gly Asp
        1395                1400                1405            
 Asp Val Lys Asn Ala Pro Gly Gln Tyr Ile Gln Cys Phe Thr Val Gln
    1410                1415                1420                
 Pro Val Leu Asp Glu His Pro Arg Phe Lys Asn Lys Pro Val Pro Asp
1425                1430                1435                1440
 Gln Ile Ile Asn Phe Tyr Lys Ser Asn Tyr Val Gln Arg Phe His Tyr
                1445                1450                1455    
 Ser Arg Pro Val Arg Arg Gly Thr Val Asp Pro Glu Asn Glu Phe Ala
            1460                1465                1470        
 Ser Met Trp Ile Glu Arg Thr Ser Phe Val Thr Ala Tyr Lys Leu Pro
        1475                1480                1485            
 Gly Ile Leu Arg Trp Phe Glu Val Val His Met Ser Gln Thr Thr Ile
    1490                1495                1500                
 Ser Pro Leu Glu Asn Ala Ile Glu Thr Met Ser Thr Ala Asn Glu Lys
1505                1510                1515                1520
 Ile Leu Met Met Ile Asn Gln Tyr Gln Ser Asp Glu Thr Leu Pro Ile
                1525                1530                1535    
 Asn Pro Leu Ser Met Leu Leu Asn Gly Ile Val Asp Pro Ala Val Met
            1540                1545                1550        
 Gly Gly Phe Ala Lys Tyr Glu Lys Ala Phe Phe Thr Glu Glu Tyr Val
        1555                1560                1565            
 Arg Asp His Pro Glu Asp Gln Asp Lys Leu Thr His Leu Lys Asp Leu
    1570                1575                1580                
 Ile Ala Trp Gln Ile Pro Phe Leu Gly Ala Gly Ile Lys Ile His Glu
1585                1590                1595                1600
 Lys Arg Val Ser Asp Asn Leu Arg Pro Phe His Asp Arg Met Glu Glu
                1605                1610                1615    
 Cys Phe Lys Asn Leu Lys Met Lys Val Glu Lys Glu Tyr Gly Val Arg
            1620                1625                1630        
 Glu Met Pro Asp Phe Asp Asp Arg Arg Val Gly Arg Pro Arg Ser Met
        1635                1640                1645            
 Leu Arg Ser Tyr Arg Gln Met Ser Ile Ile Ser Leu Ala Ser Met Asn
    1650                1655                1660                
 Ser Asp Cys Ser Thr Pro Ser Lys Pro Thr Ser Glu Ser Phe Asp Leu
1665                1670                1675                1680
 Glu Leu Ala Ser Pro Lys Thr Pro Arg Val Glu Gln Glu Glu Pro Ile
                1685                1690                1695    
 Ser Pro Gly Ser Thr Leu Pro Glu Val Lys Leu Arg Arg Ser Lys Lys
            1700                1705                1710        
 Arg Thr Lys Arg Ser Ser Val Val Phe Ala Asp Glu Lys Ala Ala Ala
        1715                1720                1725            
 Glu Ser Asp Leu Lys Arg Leu Ser Arg Lys His Glu Phe Met Ser Asp
    1730                1735                1740                
 Thr Asn Leu Ser Glu His Ala Ala Ile Pro Leu Lys Ala Ser Val Leu
1745                1750                1755                1760
 Ser Gln Met Ser Phe Ala Ser Gln Ser Met Pro Thr Ile Pro Ala Leu
                1765                1770                1775    
 Ala Leu Ser Val Ala Gly Ile Pro Gly Leu Asp Glu Ala Asn Thr Ser
            1780                1785                1790        
 Pro Arg Leu Ser Gln Thr Phe Leu Gln Leu Ser Asp Gly Asp Lys Lys
        1795                1800                1805            
 Thr Leu Thr Arg Lys Lys Val Asn Gln Phe Phe Lys Thr Met Leu Ala
    1810                1815                1820                
 Ser Lys Ser Ala Glu Glu Gly Lys Gln Ile Pro Asp Ser Leu Ser Thr
1825                1830                1835                1840
 Asp Leu
        



      <210> 2959
      <211> 105
      <212> PRT
      <213> Homo sapiens

      <220>
      <221> misc_feature
      <222> (1)...(105)
      <223> Xaa = any amino acid or symbol as shown in the table 8 as set forth in Example 2


      <400> 2959
 Cys Cys Pro Pro Gly Gly Thr Gly Arg Cys Leu Gly Thr Cys Gly Tyr
   1               5                  10                  15    
 His Asn Cys Gly Cys Ser Ile Xaa Ser Ser Asp Leu Pro Gln Arg Cys
              20                  25                  30        
 Cys Val Ser Gly Arg Arg Xaa Thr Phe Trp Met Val Trp Ser Ala Cys
          35                  40                  45            
 Val Cys Ala Ser Gly Cys Leu Pro Gly Gly Asn Arg Cys Cys Cys Pro
      50                  55                  60                
 Val Ser Leu Ser Pro Glu Arg Ile Ala Val Leu Gly Gly Leu Leu Pro
  65                  70                  75                  80
 Arg Lys Pro Pro Cys Arg Val Val Gly Glu Arg Arg Ser Val Leu Thr
                  85                  90                  95    
 Leu Gln Ala Thr Ser Gln Cys Pro Arg
             100                 105



      <210> 2960
      <211> 518
      <212> PRT
      <213> Homo sapiens


      <400> 2960
 Thr Ala Gly Phe Leu Leu Ala Pro Leu Glu Met Gln Arg Leu Leu Thr
   1               5                  10                  15    
 Pro Val Lys Arg Ile Leu Gln Leu Thr Arg Ala Val Gln Glu Thr Ser
              20                  25                  30        
 Leu Thr Pro Ala Arg Leu Leu Pro Val Ala His Gln Arg Phe Ser Thr
          35                  40                  45            
 Ala Ser Ala Val Pro Leu Ala Lys Thr Asp Thr Trp Pro Lys Asp Val
      50                  55                  60                
 Gly Ile Leu Ala Leu Glu Val Tyr Phe Pro Ala Gln Tyr Val Asp Gln
  65                  70                  75                  80
 Thr Asp Leu Glu Lys Tyr Asn Asn Val Glu Ala Gly Lys Tyr Thr Val
                  85                  90                  95    
 Gly Leu Gly Gln Thr Arg Met Gly Phe Cys Ser Val Gln Glu Asp Ile
             100                 105                 110        
 Asn Ser Leu Cys Leu Thr Val Val Gln Arg Leu Met Glu Arg Ile Gln
         115                 120                 125            
 Leu Pro Trp Asp Ser Val Gly Arg Leu Glu Val Gly Thr Glu Thr Ile
     130                 135                 140                
 Ile Asp Lys Ser Lys Ala Val Lys Thr Val Leu Met Glu Leu Phe Gln
 145                 150                 155                 160
 Asp Ser Gly Asn Thr Asp Ile Glu Gly Ile Asp Thr Thr Asn Ala Cys
                 165                 170                 175    
 Tyr Gly Gly Thr Ala Ser Leu Phe Asn Ala Ala Asn Trp Met Glu Ser
             180                 185                 190        
 Ser Ser Trp Asp Gly Arg Tyr Ala Met Val Val Cys Gly Asp Ile Ala
         195                 200                 205            
 Val Tyr Pro Ser Gly Asn Ala Arg Pro Thr Gly Gly Ala Gly Ala Val
     210                 215                 220                
 Ala Met Leu Ile Gly Pro Lys Ala Pro Leu Ala Leu Glu Arg Gly Leu
 225                 230                 235                 240
 Arg Gly Thr His Met Glu Asn Val Tyr Asp Phe Tyr Lys Pro Asn Leu
                 245                 250                 255    
 Ala Ser Glu Tyr Pro Ile Val Asp Gly Lys Leu Ser Ile Gln Cys Tyr
             260                 265                 270        
 Leu Arg Ala Leu Asp Arg Cys Tyr Thr Ser Tyr Arg Lys Lys Ile Gln
         275                 280                 285            
 Asn Gln Trp Lys Gln Ala Gly Ser Asp Arg Pro Phe Thr Leu Asp Asp
     290                 295                 300                
 Leu Gln Tyr Met Ile Phe His Thr Pro Phe Cys Lys Met Val Gln Lys
 305                 310                 315                 320
 Ser Leu Ala Arg Leu Met Phe Asn Asp Phe Leu Ser Ala Ser Ser Asp
                 325                 330                 335    
 Thr Gln Thr Ser Leu Tyr Lys Gly Leu Glu Ala Phe Gly Gly Leu Lys
             340                 345                 350        
 Leu Glu Asp Thr Tyr Thr Asn Lys Asp Leu Asp Lys Ala Leu Leu Lys
         355                 360                 365            
 Ala Ser Gln Asp Met Phe Asp Lys Lys Thr Lys Ala Ser Leu Tyr Leu
     370                 375                 380                
 Ser Thr His Asn Gly Asn Met Tyr Thr Ser Thr Leu Tyr Gly Cys Leu
 385                 390                 395                 400
 Ala Ser Leu Leu Ser His His Ser Ala Gln Glu Leu Ala Gly Ser Arg
                 405                 410                 415    
 Ile Gly Ala Phe Ser Tyr Gly Ser Gly Leu Ala Ala Ser Phe Phe Ser
             420                 425                 430        
 Phe Arg Val Ser Gln Asp Ala Ala Pro Gly Ser Pro Leu Asp Lys Leu
         435                 440                 445            
 Val Ser Ser Thr Ser Asp Leu Pro Lys Arg Leu Ala Ser Arg Lys Cys
     450                 455                 460                
 Val Ser Pro Glu Glu Phe Thr Glu Ile Met Asn Gln Arg Glu Gln Phe
 465                 470                 475                 480
 Tyr His Lys Val Asn Phe Ser Pro Pro Gly Asp Thr Asn Ser Leu Phe
                 485                 490                 495    
 Pro Gly Thr Trp Tyr Leu Glu Arg Val Asp Glu Gln His Arg Arg Lys
             500                 505                 510        
 Tyr Ala Arg Arg Pro Val
         515            



      <210> 2961
      <211> 479
      <212> PRT
      <213> Homo sapiens


      <400> 2961
 His Arg Ala Arg Val Asp Arg Ser Arg Glu Ser Pro Gly Gly Asp Leu
   1               5                  10                  15    
 Arg His Pro Gly Arg Val Arg Arg Asp Ile Thr Leu Ser Gly His Pro
              20                  25                  30        
 Arg Leu Ser Thr Gln His Val Val Leu Leu Arg Glu Asp Glu Val Gly
          35                  40                  45            
 Asp Pro Gly Thr Lys Asp Leu Gly His Pro Gln His Gly Ser Pro Ile
      50                  55                  60                
 Gln Glu Thr Gln Ser Glu Val Val Thr Leu Val Ser Pro Leu Pro Gly
  65                  70                  75                  80
 Ser Asp Met Ala Ala Leu Pro Ala Trp Arg Ala Thr Ser Gly Leu Thr
                  85                  90                  95    
 Leu Trp Pro His Thr Ala Glu Gly Arg Asp Leu Leu Gly Ala Glu Asn
             100                 105                 110        
 Arg Ala Leu Thr Gly Gly Gln Gln Ala Glu Asp Pro Thr Leu Ala Ser
         115                 120                 125            
 Gly Ala Tyr Gln Trp Pro Gly Ser Val Glu Lys Leu Gln Gly Ser Val
     130                 135                 140                
 Trp Cys Asp Ala Glu Thr Leu Leu Ser Ser Ser Arg Thr Gly Gly Gln
 145                 150                 155                 160
 Ala Pro Pro Trp Leu Thr Asp His Asp Val Gln Met Leu Arg Leu Leu
                 165                 170                 175    
 Ala Gln Gly Glu Val Val Asp Lys Ala Arg Val Pro Ala His Gly Gln
             180                 185                 190        
 Val Leu Gln Val Gly Phe Ser Thr Glu Ala Ala Leu Gln Asp Leu Ser
         195                 200                 205            
 Ser Pro Arg Leu Ser Gln Leu Cys Ser Gln Gly Leu Cys Gly Leu Ile
     210                 215                 220                
 Lys Arg Pro Gly Asp Leu Pro Glu Val Leu Ser Phe His Val Asp Arg
 225                 230                 235                 240
 Val Leu Gly Leu Arg Arg Ser Leu Pro Ala Val Ala Arg Arg Phe His
                 245                 250                 255    
 Ser Pro Leu Leu Pro Tyr Arg Tyr Thr Asp Gly Gly Ala Arg Pro Val
             260                 265                 270        
 Ile Trp Trp Ala Pro Asp Val Gln His Leu Ser Asp Pro Asp Glu Asp
         275                 280                 285            
 Gln Asn Ser Leu Ala Leu Gly Trp Leu Gln Tyr Gln Ala Leu Leu Ala
     290                 295                 300                
 His Ser Cys Asn Trp Pro Gly Gln Ala Pro Cys Pro Gly Ile His His
 305                 310                 315                 320
 Thr Glu Trp Ala Arg Leu Ala Leu Phe Asp Phe Leu Leu Gln Val His
                 325                 330                 335    
 Asp Arg Leu Asp Arg Tyr Cys Cys Gly Phe Glu Pro Glu Pro Ser Asp
             340                 345                 350        
 Pro Cys Val Glu Glu Arg Leu Arg Glu Lys Cys Arg Asn Pro Ala Glu
         355                 360                 365            
 Leu Arg Leu Val His Ile Leu Val Arg Ser Ser Asp Pro Ser His Leu
     370                 375                 380                
 Val Tyr Ile Asp Asn Ala Gly Asn Leu Gln His Pro Glu Asp Lys Leu
 385                 390                 395                 400
 Asn Phe Arg Leu Leu Glu Gly Ile Asp Gly Phe Pro Glu Ser Ala Val
                 405                 410                 415    
 Lys Val Leu Ala Ser Gly Cys Leu Gln Asn Met Leu Leu Lys Ser Leu
             420                 425                 430        
 Gln Met Asp Pro Val Phe Trp Glu Ser Gln Gly Gly Ala Gln Gly Leu
         435                 440                 445            
 Lys Gln Val Leu Gln Thr Leu Glu Gln Arg Gly Gln Val Leu Leu Gly
     450                 455                 460                
 His Ile Gln Lys His Asn Leu Thr Leu Phe Arg Asp Glu Asp Pro
 465                 470                 475                



      <210> 2962
      <211> 202
      <212> PRT
      <213> Homo sapiens

      <220>
      <221> misc_feature
      <222> (1)...(202)
      <223> Xaa = any amino acid or symbol as shown in the table 8 as set forth in Example 2


      <400> 2962
 Ile Ser Trp Pro Ser Pro Ser Leu Leu Gly Gln Thr Ala Ala Leu Cys
   1               5                  10                  15    
 Ala Asn Gly Ala Gly Pro Ala Gly Thr Pro Pro Gly Arg Gly Pro Val
              20                  25                  30        
 Ser Ala Arg Phe Gly Arg Arg Gly Ala Ala Cys Val Cys Ser Pro Pro
          35                  40                  45            
 Ser Pro Ser Pro Leu Ala Pro Leu Ser Arg Xaa Arg Phe Ala Val Met
      50                  55                  60                
 Trp Trp Gln Glu Ala Xaa Arg Arg Gly Pro Arg Leu Pro Leu Leu Ser
  65                  70                  75                  80
 Ser Leu Pro Ala Ala Ala Gly Ser Gly Arg Ala Ala Arg Ala Ala Ala
                  85                  90                  95    
 Glu Leu Pro Gly Gly Gly Arg Ala Gly Ala Arg Pro Leu Leu Leu Thr
             100                 105                 110        
 Pro Ala Gln Val Gln Gly Glu Ser Ala Arg Gly Ala Gly Ala Glu Gly
         115                 120                 125            
 Gly Arg Gly Thr Pro Gly Pro Gly Cys Pro Leu Pro Ala Gly Arg Ser
     130                 135                 140                
 Leu Cys Gln Pro Gly Pro Arg Ser Pro Pro Xaa Thr Ala Ala Leu Cys
 145                 150                 155                 160
 Ala Asn Gly Ala Gly Pro Ala Gly Thr Pro Pro Gly Arg Gly Pro Val
                 165                 170                 175    
 Ser Ala Arg Phe Gly Arg Arg Gly Ala Ala Cys Val Cys Ser Pro Pro
             180                 185                 190        
 Ser Pro Ser Pro Leu Ala Pro Leu Ser Arg
         195                 200        



      <210> 2963
      <211> 138
      <212> PRT
      <213> Homo sapiens

      <220>
      <221> misc_feature
      <222> (1)...(138)
      <223> Xaa = any amino acid or symbol as shown in the table 8 as set forth in Example 2


      <400> 2963
 Arg Cys His Pro Arg Thr Pro Gly Asn Met Ala Leu Arg Val Val Arg
   1               5                  10                  15    
 Ser Val Arg Ala Val Leu Cys Ser Leu His Val Val Leu Ala Pro Ala
              20                  25                  30        
 Ala Pro Cys Leu Ser Arg Pro Trp Gln Leu Gly Met Gly Ala Val Trp
          35                  40                  45            
 Tyr Cys Asn Leu Pro Glu Val Gly Thr Lys Leu Asn Lys Gln Asp Glu
      50                  55                  60                
 Phe Gly Ala Leu Glu Ser Val Lys Ala Ala Ser Glu Leu Tyr Ser Pro
  65                  70                  75                  80
 Leu Ser Gly Glu Val Thr Glu Ile Asn Glu Ala Leu Ala Glu Asn Pro
                  85                  90                  95    
 Gly Leu Val Asn Lys Ser Arg Tyr Glu Asp Gly Trp Leu Ile Lys Met
             100                 105                 110        
 Thr Leu Ser Asn Pro Ser Xaa Leu Asp Glu Leu Met Ser Glu Glu Ala
         115                 120                 125            
 Tyr Glu Lys Tyr Ile Lys Ser Ile Glu Glu
     130                 135            



      <210> 2964
      <211> 137
      <212> PRT
      <213> Homo sapiens


      <400> 2964
 Trp Pro Ser Gly Gln Val Leu Val Gly Cys Leu Ser Phe Ser Leu Tyr
   1               5                  10                  15    
 Cys Trp Lys Arg Ser Leu Lys Arg Lys Asn Pro Gly Phe Glu Val Leu
              20                  25                  30        
 Leu Lys Ile Phe Leu Lys Asn His Pro Arg Cys His Thr Asn Arg Met
          35                  40                  45            
 Ile Gln Leu Thr Ala Thr Pro Val Ser Ala Leu Ala Asp Glu Pro Ala
      50                  55                  60                
 His Ile Arg Ala Thr Gly Leu Ile Pro Phe Gln Met Val Ser Phe Gln
  65                  70                  75                  80
 Ala Ser Leu Glu Asp Glu Asn Gly Asp Met Phe Tyr Ser Gln Ala His
                  85                  90                  95    
 Tyr Arg Ala Asn Glu Phe Ala Glu Ala Asp Leu Asn His Ala Ala Ser
             100                 105                 110        
 Leu Gly Gly Asp Tyr Leu Gly Asp Leu Ala Leu Arg Leu Leu Cys Thr
         115                 120                 125            
 Leu Glu Pro Val Phe Pro Gln Ser Tyr
     130                 135        



      <210> 2965
      <211> 383
      <212> PRT
      <213> Homo sapiens


      <400> 2965
 Arg Pro Leu Pro Arg Arg Gly Ala Gly Gly Arg Glu Ala Trp Gly Arg
   1               5                  10                  15    
 Gly His Arg Leu Gly Ser Ser Gly Ser Pro Gly Asp Arg Val Glu Met
              20                  25                  30        
 Asn Thr Glu Ala Glu Gln Gln Leu Leu His His Ala Arg Asn Gly Asn
          35                  40                  45            
 Ala Glu Glu Val Arg Gln Leu Leu Glu Thr Met Ala Arg Asn Glu Val
      50                  55                  60                
 Ile Ala Asp Ile Asn Cys Lys Gly Arg Ser Lys Ser Asn Leu Gly Trp
  65                  70                  75                  80
 Thr Pro Leu His Leu Ala Cys Tyr Phe Gly His Arg Gln Val Val Gln
                  85                  90                  95    
 Asp Leu Leu Lys Ala Gly Ala Glu Val Asn Val Leu Asn Asp Met Gly
             100                 105                 110        
 Asp Thr Pro Leu His Arg Ala Ala Phe Thr Gly Arg Lys Glu Leu Val
         115                 120                 125            
 Met Leu Leu Leu Glu Tyr Asn Ala Asp Thr Thr Ile Val Asn Gly Ser
     130                 135                 140                
 Gly Gln Thr Ala Lys Glu Val Thr His Ala Glu Glu Ile Thr Ser Met
 145                 150                 155                 160
 Leu Glu Ala Val Glu Arg Thr Gln Gln Arg Lys Leu Glu Glu Leu Leu
                 165                 170                 175    
 Leu Ala Ala Ala Arg Glu Gly Lys Thr Thr Glu Leu Thr Ala Leu Leu
             180                 185                 190        
 Asn Arg Pro Asn Pro Pro Asp Val Asn Cys Ser Asp Gln Leu Gly Asn
         195                 200                 205            
 Thr Pro Leu His Trp Ala Ala Tyr Arg Ala His Lys Gln Trp Ala Leu
     210                 215                 220                
 Lys Leu Leu Lys Ser Gly Ala Asp Pro Asn Leu Lys Asn Lys Asn Asp
 225                 230                 235                 240
 Gln Lys Pro Leu Asp Leu Ala Gln Gly Ala Glu Met Lys His Ile Leu
                 245                 250                 255    
 Val Gly Asn Lys Val Ile Tyr Lys Ala Leu Lys Arg Tyr Glu Gly Pro
             260                 265                 270        
 Leu Trp Lys Ser Ser Arg Phe Phe Gly Trp Arg Leu Phe Trp Val Val
         275                 280                 285            
 Leu Glu His Gly Val Leu Ser Trp Tyr Arg Lys Gln Pro Asp Ala Val
     290                 295                 300                
 His Asn Ile Tyr Arg Gln Gly Cys Lys Arg Leu Thr Gln Ala Val Cys
 305                 310                 315                 320
 Thr Val Lys Ser Thr Asp Ser Cys Leu Phe Phe Ile Lys Cys Phe Asp
                 325                 330                 335    
 Asp Ala Ile His Gly Phe Arg Val Pro Lys Asn Ser Leu Gln Gln Ser
             340                 345                 350        
 Arg Glu Ala Trp Leu Glu Ala Ile Val Ala Leu Ser Ala Tyr Ser Ala
         355                 360                 365            
 His Tyr Cys Thr Gln Asn Gln Leu Thr Asp Glu Glu Glu Val Tyr
     370                 375                 380            



      <210> 2966
      <211> 64
      <212> PRT
      <213> Homo sapiens


      <400> 2966
 Met Pro Gly Tyr Val Pro Leu Leu Leu Leu Leu Leu Leu Leu Arg Cys
   1               5                  10                  15    
 Ser Gln Arg Gly Gly Gly Val Asn Phe Gly Glu Lys Asp Ala Lys Val
              20                  25                  30        
 Pro Gly Thr Trp Arg Asp Gly Val Arg Val Pro Gly Glu Gly Ala Ser
          35                  40                  45            
 Trp Asp Ser Asp Arg Ala Ser Pro Glu Arg Arg Tyr Gly Ile Gly Glu
      50                  55                  60                





      <210> 2967
      <211> 445
      <212> PRT
      <213> Homo sapiens


      <400> 2967
 Pro Ser Ser Pro Pro Pro Leu Gly Cys Val Leu Arg Leu Pro Ala Pro
   1               5                  10                  15    
 Pro Arg Pro Gly Ser Arg Ser Gly Cys Gly Arg Thr Ala Leu Arg Gly
              20                  25                  30        
 Arg Pro Leu Gly Ile Gln Arg Ala Arg Ser Ser Leu Val Glu Gly Thr
          35                  40                  45            
 Met Asn Trp His Leu Pro Leu Phe Leu Leu Ala Ser Val Thr Leu Pro
      50                  55                  60                
 Ser Ile Cys Ser His Phe Asn Pro Leu Ser Leu Glu Glu Leu Gly Ser
  65                  70                  75                  80
 Asn Thr Gly Ile Gln Val Phe Asn Gln Ile Val Lys Ser Arg Pro His
                  85                  90                  95    
 Asp Asn Ile Val Ile Ser Pro His Gly Ile Ala Ser Val Leu Gly Met
             100                 105                 110        
 Leu Gln Leu Gly Ala Asp Gly Arg Thr Lys Lys Gln Leu Ala Met Val
         115                 120                 125            
 Met Arg Tyr Gly Val Asn Gly Val Gly Lys Ile Leu Lys Lys Ile Asn
     130                 135                 140                
 Lys Ala Ile Val Ser Lys Lys Asn Lys Asp Ile Val Thr Val Ala Asn
 145                 150                 155                 160
 Ala Val Phe Val Lys Asn Ala Ser Glu Ile Glu Val Pro Phe Val Thr
                 165                 170                 175    
 Arg Asn Lys Asp Val Phe Gln Cys Glu Val Arg Asn Val Asn Phe Glu
             180                 185                 190        
 Asp Pro Ala Ser Ala Cys Asp Ser Ile Asn Ala Trp Val Lys Asn Glu
         195                 200                 205            
 Thr Arg Asp Met Ile Asp Asn Leu Leu Ser Pro Asp Leu Ile Asp Gly
     210                 215                 220                
 Val Leu Thr Arg Leu Val Leu Val Asn Ala Val Tyr Phe Lys Gly Leu
 225                 230                 235                 240
 Trp Lys Ser Arg Phe Gln Pro Glu Asn Thr Lys Lys Arg Thr Phe Val
                 245                 250                 255    
 Ala Ala Asp Gly Lys Ser Tyr Gln Val Pro Met Leu Ala Gln Leu Ser
             260                 265                 270        
 Val Phe Arg Cys Gly Ser Thr Ser Ala Pro Asn Asp Leu Trp Tyr Asn
         275                 280                 285            
 Phe Ile Glu Leu Pro Tyr His Gly Glu Ser Ile Ser Met Leu Ile Ala
     290                 295                 300                
 Leu Pro Thr Glu Ser Ser Thr Pro Leu Ser Ala Ile Ile Pro His Ile
 305                 310                 315                 320
 Ser Thr Lys Thr Ile Asp Ser Trp Met Ser Ile Met Val Pro Lys Arg
                 325                 330                 335    
 Val Gln Val Ile Leu Pro Lys Phe Thr Ala Val Ala Gln Thr Asp Leu
             340                 345                 350        
 Lys Glu Pro Leu Lys Val Leu Gly Ile Thr Asp Met Phe Asp Ser Ser
         355                 360                 365            
 Lys Ala Asn Phe Ala Lys Ile Thr Arg Ser Glu Asn Leu His Val Ser
     370                 375                 380                
 His Ile Leu Gln Lys Ala Lys Ile Glu Val Ser Glu Asp Gly Thr Lys
 385                 390                 395                 400
 Ala Ser Ala Ala Thr Thr Ala Ile Leu Ile Ala Arg Ser Ser Pro Pro
                 405                 410                 415    
 Trp Phe Ile Val Asp Arg Pro Phe Leu Phe Phe Ile Arg His Asn Pro
             420                 425                 430        
 Thr Gly Ala Val Leu Phe Met Gly Gln Ile Asn Lys Pro
         435                 440                 445



      <210> 2968
      <211> 147
      <212> PRT
      <213> Homo sapiens


      <400> 2968
 Asp Thr Tyr Cys Arg Gly Asp Gln Leu His Ile Leu Leu Glu Val Arg
   1               5                  10                  15    
 Asp His Leu Gly Arg Arg Lys Gln Tyr Gly Gly Asp Phe Leu Arg Ala
              20                  25                  30        
 Arg Met Ser Ser Pro Ala Leu Met Ala Gly Ala Ser Gly Lys Val Thr
          35                  40                  45            
 Asp Phe Asn Asn Gly Thr Tyr Leu Val Ser Phe Thr Leu Phe Trp Glu
      50                  55                  60                
 Gly Gln Val Ser Leu Ser Leu Leu Leu Ile His Pro Ser Glu Gly Val
  65                  70                  75                  80
 Ser Ala Leu Trp Ser Ala Arg Asn Gln Gly Tyr Asp Arg Val Ile Phe
                  85                  90                  95    
 Thr Gly Gln Phe Val Asn Gly Thr Ser Gln Val His Ser Glu Cys Gly
             100                 105                 110        
 Leu Ile Leu Asn Thr Asn Ala Glu Leu Cys Gln Tyr Leu Asp Asn Arg
         115                 120                 125            
 Asp Gln Glu Ser Phe Tyr Trp Val Arg Pro Gln His Met Arg Cys Ala
     130                 135                 140                
 Ala Leu Thr
 145        



      <210> 2969
      <211> 1646
      <212> PRT
      <213> Homo sapiens


      <400> 2969
 Ser Ala Ala Leu Gly Ala Ser Leu Ala Ile Pro Arg Pro Gly Leu Pro
   1               5                  10                  15    
 Gly Val His Gly Arg Gly Pro Gly Thr Leu Ser Gly Arg Ala Met Glu
              20                  25                  30        
 Gly Ala Glu Pro Arg Ala Arg Pro Glu Arg Leu Ala Glu Ala Glu Thr
          35                  40                  45            
 Arg Ala Ala Asp Gly Gly Arg Leu Val Glu Val Gln Leu Ser Gly Gly
      50                  55                  60                
 Ala Pro Trp Gly Phe Thr Leu Lys Gly Gly Arg Glu His Gly Glu Pro
  65                  70                  75                  80
 Leu Val Ile Thr Lys Ile Glu Glu Gly Ser Lys Ala Ala Ala Val Asp
                  85                  90                  95    
 Lys Leu Leu Ala Gly Asp Glu Ile Val Gly Ile Asn Asp Ile Gly Leu
             100                 105                 110        
 Ser Gly Phe Arg Gln Glu Ala Ile Cys Leu Val Lys Gly Ser His Lys
         115                 120                 125            
 Thr Leu Lys Leu Val Val Lys Arg Arg Ser Glu Leu Gly Trp Arg Pro
     130                 135                 140                
 His Ser Trp His Ala Thr Lys Phe Ser Asp Ser His Pro Glu Leu Ala
 145                 150                 155                 160
 Ala Ser Pro Phe Thr Ser Thr Ser Gly Cys Pro Ser Trp Ser Gly Arg
                 165                 170                 175    
 His His Ala Ser Ser Ser Ser His Asp Leu Ser Ser Ser Trp Glu Gln
             180                 185                 190        
 Thr Asn Leu Gln Arg Thr Leu Asp His Phe Ser Ser Leu Gly Ser Val
         195                 200                 205            
 Asp Ser Leu Asp His Pro Ser Ser Arg Leu Ser Val Ala Lys Ser Asn
     210                 215                 220                
 Ser Ser Ile Asp His Leu Gly Ser His Ser Lys Arg Asp Ser Ala Tyr
 225                 230                 235                 240
 Gly Ser Phe Ser Thr Ser Ser Ser Thr Pro Asp His Thr Leu Ser Lys
                 245                 250                 255    
 Ala Asp Thr Ser Ser Ala Glu Asn Ile Leu Tyr Thr Val Gly Leu Trp
             260                 265                 270        
 Glu Ala Pro Arg Gln Gly Gly Arg Gln Ala Gln Ala Ala Gly Asp Pro
         275                 280                 285            
 Gln Gly Ser Glu Glu Lys Leu Ser Cys Phe Pro Pro Arg Val Pro Gly
     290                 295                 300                
 Asp Ser Gly Lys Gly Pro Arg Pro Glu Tyr Asn Ala Glu Pro Lys Leu
 305                 310                 315                 320
 Ala Ala Pro Gly Arg Ser Asn Phe Gly Pro Val Trp Tyr Val Pro Asp
                 325                 330                 335    
 Lys Lys Lys Ala Pro Ser Ser Pro Pro Pro Pro Pro Pro Pro Leu Arg
             340                 345                 350        
 Ser Asp Ser Phe Ala Ala Thr Lys Ser His Glu Lys Ala Gln Gly Pro
         355                 360                 365            
 Val Phe Ser Glu Ala Ala Ala Ala Gln His Phe Thr Ala Leu Ala Gln
     370                 375                 380                
 Ala Gln Pro Arg Gly Asp Arg Arg Pro Glu Leu Thr Asp Arg Pro Trp
 385                 390                 395                 400
 Arg Ser Ala His Pro Gly Ser Leu Gly Lys Gly Ser Gly Gly Pro Gly
                 405                 410                 415    
 Cys Pro Gln Glu Ala His Ala Asp Gly Ser Trp Pro Pro Ser Lys Asp
             420                 425                 430        
 Gly Ala Ser Ser Arg Leu Gln Ala Ser Leu Ser Ser Ser Asp Val Arg
         435                 440                 445            
 Phe Pro Gln Ser Pro His Ser Gly Arg His Pro Pro Leu Tyr Ser Asp
     450                 455                 460                
 His Ser Pro Leu Cys Ala Asp Ser Leu Gly Gln Glu Pro Gly Ala Ala
 465                 470                 475                 480
 Ser Phe Gln Asn Asp Ser Pro Pro Gln Val Arg Gly Leu Ser Ser Cys
                 485                 490                 495    
 Asp Gln Lys Leu Gly Ser Gly Trp Gln Gly Pro Arg Pro Cys Val Gln
             500                 505                 510        
 Gly Asp Leu Gln Ala Ala Gln Leu Trp Ala Gly Cys Trp Pro Ser Asp
         515                 520                 525            
 Thr Ala Leu Gly Ala Leu Glu Ser Leu Pro Pro Pro Thr Val Gly Gln
     530                 535                 540                
 Ser Pro Arg His His Leu Pro Gln Pro Glu Gly Pro Pro Asp Ala Arg
 545                 550                 555                 560
 Glu Thr Gly Arg Cys Tyr Pro Leu Asp Lys Gly Ala Glu Gly Cys Ser
                 565                 570                 575    
 Ala Gly Ala Gln Glu Pro Pro Arg Ala Ser Arg Ala Glu Lys Ala Ser
             580                 585                 590        
 Gln Arg Leu Ala Ala Ser Ile Thr Trp Ala Asp Gly Glu Ser Ser Arg
         595                 600                 605            
 Ile Cys Pro Gln Glu Thr Pro Leu Leu His Ser Leu Thr Gln Glu Gly
     610                 615                 620                
 Lys Arg Arg Pro Glu Ser Ser Pro Glu Asp Ser Ala Thr Arg Pro Pro
 625                 630                 635                 640
 Pro Phe Asp Ala His Val Gly Lys Pro Thr Arg Arg Ser Asp Arg Phe
                 645                 650                 655    
 Ala Thr Thr Leu Arg Asn Glu Ile Gln Met His Arg Ala Lys Leu Gln
             660                 665                 670        
 Lys Ser Arg Ser Thr Val Ala Leu Thr Ala Ala Gly Glu Ala Glu Asp
         675                 680                 685            
 Gly Thr Gly Arg Trp Arg Ala Gly Leu Gly Gly Gly Thr Gln Glu Gly
     690                 695                 700                
 Pro Leu Ala Gly Thr Tyr Lys Asp His Leu Lys Glu Ala Gln Ala Arg
 705                 710                 715                 720
 Val Leu Arg Ala Thr Ser Phe Lys Arg Arg Asp Leu Asp Pro Asn Pro
                 725                 730                 735    
 Gly Asp Leu Tyr Pro Glu Ser Leu Glu His Arg Met Gly Asp Pro Asp
             740                 745                 750        
 Thr Val Pro His Phe Trp Glu Ala Gly Leu Ala Gln Pro Pro Ser Ser
         755                 760                 765            
 Thr Ser Gly Gly Pro His Pro Pro Arg Ile Gly Gly Arg Arg Arg Phe
     770                 775                 780                
 Thr Ala Glu Gln Lys Leu Lys Ser Tyr Ser Glu Pro Glu Lys Met Asn
 785                 790                 795                 800
 Glu Val Gly Leu Thr Arg Gly Tyr Ser Pro His Gln His Pro Arg Thr
                 805                 810                 815    
 Ser Glu Asp Thr Val Gly Thr Phe Ala Asp Arg Trp Lys Phe Phe Glu
             820                 825                 830        
 Glu Thr Ser Lys Pro Val Pro Gln Arg Pro Ala Gln Lys Gln Ala Leu
         835                 840                 845            
 His Gly Ile Pro Arg Asp Lys Pro Glu Arg Pro Arg Thr Ala Gly Arg
     850                 855                 860                
 Thr Cys Glu Gly Thr Glu Pro Trp Ser Arg Thr Thr Ser Leu Gly Asp
 865                 870                 875                 880
 Ser Leu Asn Ala His Ser Ala Ala Glu Lys Ala Gly Thr Ser Asp Leu
                 885                 890                 895    
 Pro Arg Arg Leu Gly Thr Phe Ala Glu Tyr Gln Ala Ser Trp Lys Glu
             900                 905                 910        
 Gln Arg Lys Pro Leu Glu Ala Arg Ser Ser Gly Arg Cys His Ser Ala
         915                 920                 925            
 Asp Asp Ile Leu Asp Val Ser Leu Asp Pro Gln Glu Arg Pro Gln His
     930                 935                 940                
 Val His Gly Arg Ser Arg Ser Ser Pro Ser Thr Asp His Tyr Lys Gln
 945                 950                 955                 960
 Glu Ala Ser Val Glu Leu Arg Arg Gln Ala Gly Asp Pro Gly Glu Pro
                 965                 970                 975    
 Arg Glu Glu Leu Pro Ser Ala Val Arg Ala Glu Glu Gly Gln Ser Thr
             980                 985                 990        
 Pro Arg Gln Ala Asp Ala Gln Cys Arg Glu Gly Ser Pro Gly Ser Gln
         995                1000                1005            
 Gln His Pro Pro Ser Gln Lys Ala Pro Asn Pro Pro Thr Phe Ser Glu
    1010                1015                1020                
 Leu Ser His Cys Arg Gly Ala Pro Glu Leu Pro Arg Glu Gly Arg Gly
1025                1030                1035                1040
 Arg Ala Gly Thr Leu Pro Arg Asp Tyr Arg Tyr Ser Glu Glu Ser Thr
                1045                1050                1055    
 Pro Ala Asp Leu Gly Pro Arg Ala Gln Ser Pro Gly Ser Pro Leu His
            1060                1065                1070        
 Ala Arg Gly Gln Asp Ser Trp Pro Val Ser Ser Ala Leu Leu Ser Lys
        1075                1080                1085            
 Arg Pro Ala Pro Gln Arg Pro Pro Pro Pro Lys Arg Glu Pro Arg Arg
    1090                1095                1100                
 Tyr Arg Ala Thr Asp Gly Ala Pro Ala Asp Ala Pro Val Gly Val Leu
1105                1110                1115                1120
 Gly Arg Pro Phe Pro Thr Pro Ser Pro Ala Ser Leu Asp Val Tyr Val
                1125                1130                1135    
 Ala Arg Leu Ser Leu Ser His Ser Pro Ser Val Phe Ser Ser Ala Gln
            1140                1145                1150        
 Pro Gln Asp Thr Pro Lys Ala Thr Val Cys Glu Arg Gly Ser Gln His
        1155                1160                1165            
 Val Ser Gly Asp Ala Ser Arg Pro Leu Pro Glu Ala Leu Leu Pro Pro
    1170                1175                1180                
 Lys Gln Gln His Leu Arg Leu Gln Thr Ala Thr Met Glu Thr Ser Arg
1185                1190                1195                1200
 Ser Pro Ser Pro Gln Phe Ala Pro Gln Lys Leu Thr Asp Lys Pro Pro
                1205                1210                1215    
 Leu Leu Ile Gln Asp Glu Asp Ser Thr Arg Ile Glu Arg Val Met Asp
            1220                1225                1230        
 Asn Asn Thr Thr Val Lys Met Val Pro Ile Lys Ile Val His Ser Glu
        1235                1240                1245            
 Ser Gln Pro Glu Lys Glu Ser Arg Gln Ser Leu Ala Cys Pro Ala Glu
    1250                1255                1260                
 Pro Pro Ala Leu Pro His Gly Leu Glu Lys Asp Gln Ile Lys Thr Leu
1265                1270                1275                1280
 Ser Thr Ser Glu Gln Phe Tyr Ser Arg Phe Cys Leu Tyr Thr Arg Gln
                1285                1290                1295    
 Gly Ala Glu Pro Glu Ala Pro His Arg Ala Gln Pro Ala Glu Pro Gln
            1300                1305                1310        
 Pro Leu Gly Thr Gln Val Pro Pro Glu Lys Asp Arg Cys Thr Ser Pro
        1315                1320                1325            
 Pro Gly Leu Ser Tyr Met Lys Ala Lys Glu Lys Thr Val Glu Asp Leu
    1330                1335                1340                
 Lys Ser Glu Glu Leu Ala Arg Glu Ile Val Gly Lys Asp Lys Ser Leu
1345                1350                1355                1360
 Ala Asp Ile Leu Asp Pro Ser Val Lys Ile Lys Thr Thr Met Asp Leu
                1365                1370                1375    
 Met Glu Gly Ile Phe Pro Lys Asp Glu His Leu Leu Glu Glu Ala Gln
            1380                1385                1390        
 Gln Arg Arg Lys Leu Leu Pro Lys Ile Pro Ser Pro Arg Ser Thr Glu
        1395                1400                1405            
 Glu Arg Lys Glu Glu Pro Ser Val Pro Ala Ala Val Ser Leu Ala Thr
    1410                1415                1420                
 Asn Ser Thr Tyr Tyr Ser Thr Ser Ala Pro Lys Ala Glu Leu Leu Ile
1425                1430                1435                1440
 Lys Met Lys Asp Leu Gln Glu Gln Gln Glu His Glu Glu Asp Ser Gly
                1445                1450                1455    
 Ser Asp Leu Asp His Asp Leu Ser Val Lys Lys Gln Glu Leu Ile Glu
            1460                1465                1470        
 Ser Ile Ser Arg Lys Leu Gln Val Leu Arg Glu Ala Arg Glu Ser Leu
        1475                1480                1485            
 Leu Glu Asp Val Gln Ala Asn Thr Val Leu Gly Ala Glu Val Glu Ala
    1490                1495                1500                
 Ile Val Lys Gly Val Cys Lys Pro Ser Glu Phe Asp Lys Phe Arg Met
1505                1510                1515                1520
 Phe Ile Gly Asp Leu Asp Lys Val Val Asn Leu Leu Leu Ser Leu Ser
                1525                1530                1535    
 Gly Arg Leu Ala Arg Val Glu Asn Ala Leu Asn Asn Leu Asp Asp Gly
            1540                1545                1550        
 Ala Ser Pro Gly Asp Arg Gln Ser Leu Leu Glu Lys Gln Arg Val Leu
        1555                1560                1565            
 Ile Gln Gln His Glu Asp Ala Lys Glu Leu Lys Glu Asn Leu Asp Arg
    1570                1575                1580                
 Arg Glu Arg Ile Val Phe Asp Ile Leu Ala Asn Tyr Leu Ser Glu Glu
1585                1590                1595                1600
 Ser Leu Ala Asp Tyr Glu His Phe Val Lys Met Lys Ser Ala Leu Ile
                1605                1610                1615    
 Ile Glu Gln Arg Glu Leu Glu Asp Lys Ile His Leu Gly Glu Glu Gln
            1620                1625                1630        
 Leu Lys Cys Leu Leu Asp Ser Leu Gln Pro Glu Arg Gly Lys
        1635                1640                1645    



      <210> 2970
      <211> 944
      <212> PRT
      <213> Homo sapiens


      <400> 2970
 Ser Lys Lys Met Val Phe Leu Pro Leu Lys Trp Ser Leu Ala Thr Met
   1               5                  10                  15    
 Ser Phe Leu Leu Ser Ser Leu Leu Ala Leu Leu Thr Val Ser Thr Pro
              20                  25                  30        
 Ser Trp Cys Gln Ser Thr Glu Ala Ser Pro Lys Arg Ser Asp Gly Thr
          35                  40                  45            
 Pro Phe Pro Trp Asn Lys Ile Arg Leu Pro Glu Tyr Val Ile Pro Val
      50                  55                  60                
 His Tyr Asp Leu Leu Ile His Ala Asn Leu Thr Thr Leu Thr Phe Trp
  65                  70                  75                  80
 Gly Thr Thr Lys Val Glu Ile Thr Ala Ser Gln Pro Thr Ser Thr Ile
                  85                  90                  95    
 Ile Leu His Ser His His Leu Gln Ile Ser Arg Ala Thr Leu Arg Lys
             100                 105                 110        
 Gly Ala Gly Glu Arg Leu Ser Glu Glu Pro Leu Gln Val Leu Glu His
         115                 120                 125            
 Pro Pro Gln Glu Gln Ile Ala Leu Leu Ala Pro Glu Pro Leu Phe Val
     130                 135                 140                
 Gly Leu Pro Tyr Thr Val Val Ile His Tyr Ala Gly Asn Leu Ser Glu
 145                 150                 155                 160
 Thr Phe His Gly Phe Tyr Lys Ser Thr Tyr Arg Thr Lys Glu Gly Glu
                 165                 170                 175    
 Leu Arg Ile Leu Ala Ser Thr Gln Phe Glu Pro Thr Ala Ala Arg Met
             180                 185                 190        
 Ala Phe Pro Cys Phe Asp Glu Pro Ala Phe Lys Ala Ser Phe Ser Ile
         195                 200                 205            
 Lys Ile Arg Arg Glu Pro Arg His Leu Ala Ile Ser Asn Met Pro Leu
     210                 215                 220                
 Val Lys Ser Val Thr Val Ala Glu Gly Leu Ile Glu Asp His Phe Asp
 225                 230                 235                 240
 Val Pro Val Lys Met Ser Thr Tyr Leu Val Ala Phe Ile Ile Ser Asp
                 245                 250                 255    
 Phe Glu Ser Val Ser Lys Ile Thr Lys Ser Gly Val Lys Val Ser Val
             260                 265                 270        
 Tyr Ala Val Pro Asp Lys Ile Asn Gln Ala Asp Tyr Ala Leu Asp Ala
         275                 280                 285            
 Ala Val Thr Leu Leu Glu Phe Tyr Glu Asp Tyr Phe Ser Ile Pro Tyr
     290                 295                 300                
 Pro Leu Pro Lys Gln Asp Leu Ala Ala Ile Pro Asp Phe Gln Ser Gly
 305                 310                 315                 320
 Ala Met Glu Asn Trp Gly Leu Thr Thr Tyr Arg Glu Ser Ala Leu Leu
                 325                 330                 335    
 Phe Asp Ala Glu Lys Ser Ser Ala Ser Ser Lys Leu Gly Ile Thr Val
             340                 345                 350        
 Thr Val Ala His Glu Leu Ala His Gln Trp Phe Gly Asn Leu Val Thr
         355                 360                 365            
 Met Glu Trp Trp Asn Asp Leu Trp Leu Asn Glu Gly Phe Ala Lys Phe
     370                 375                 380                
 Met Glu Phe Val Ser Val Ser Val Thr His Pro Glu Leu Lys Val Gly
 385                 390                 395                 400
 Asp Tyr Phe Phe Gly Lys Cys Phe Asp Ala Met Glu Val Asp Ala Leu
                 405                 410                 415    
 Asn Ser Ser His Pro Val Ser Thr Pro Val Glu Asn Pro Ala Gln Ile
             420                 425                 430        
 Arg Glu Met Phe Asp Asp Val Ser Tyr Asp Lys Gly Ala Cys Ile Leu
         435                 440                 445            
 Asn Met Leu Arg Glu Tyr Leu Ser Ala Asp Ala Phe Lys Ser Gly Ile
     450                 455                 460                
 Val Gln Tyr Leu Gln Lys His Ser Tyr Lys Asn Thr Lys Asn Glu Asp
 465                 470                 475                 480
 Leu Trp Asp Ser Met Ala Ser Ile Cys Pro Thr Asp Gly Val Lys Gly
                 485                 490                 495    
 Met Asp Gly Phe Cys Ser Arg Ser Gln His Ser Ser Ser Ser Ser His
             500                 505                 510        
 Trp His Gln Glu Gly Val Asp Val Lys Thr Met Met Asn Thr Trp Thr
         515                 520                 525            
 Leu Gln Arg Gly Phe Pro Leu Ile Thr Ile Thr Val Arg Gly Arg Asn
     530                 535                 540                
 Val His Met Lys Gln Glu His Tyr Met Lys Gly Ser Asp Gly Ala Pro
 545                 550                 555                 560
 Asp Thr Gly Tyr Leu Trp His Val Pro Leu Thr Phe Ile Thr Ser Lys
                 565                 570                 575    
 Ser Asp Met Val His Arg Phe Leu Leu Lys Thr Lys Thr Asp Val Leu
             580                 585                 590        
 Ile Leu Pro Glu Glu Val Glu Trp Ile Lys Phe Asn Val Gly Met Asn
         595                 600                 605            
 Gly Tyr Tyr Ile Val His Tyr Glu Asp Asp Gly Trp Asp Ser Leu Thr
     610                 615                 620                
 Gly Leu Leu Lys Gly Thr His Thr Ala Val Ser Ser Asn Asp Arg Ala
 625                 630                 635                 640
 Ser Leu Ile Asn Asn Ala Phe Gln Leu Val Ser Ile Gly Lys Leu Ser
                 645                 650                 655    
 Ile Glu Lys Ala Leu Asp Leu Ser Leu Tyr Leu Lys His Glu Thr Glu
             660                 665                 670        
 Ile Met Pro Val Phe Gln Gly Leu Asn Glu Leu Ile Pro Met Tyr Lys
         675                 680                 685            
 Leu Met Glu Lys Arg Asp Met Asn Glu Val Glu Thr Gln Phe Lys Ala
     690                 695                 700                
 Phe Leu Ile Arg Leu Leu Arg Asp Leu Ile Asp Lys Gln Thr Trp Thr
 705                 710                 715                 720
 Asp Glu Gly Ser Val Ser Glu Gln Met Leu Arg Ser Glu Leu Leu Leu
                 725                 730                 735    
 Leu Ala Cys Val His Asn Tyr Gln Pro Cys Val Gln Arg Ala Glu Gly
             740                 745                 750        
 Tyr Phe Arg Lys Trp Lys Glu Ser Asn Gly Asn Leu Ser Leu Pro Val
         755                 760                 765            
 Asp Val Thr Leu Ala Val Phe Ala Val Gly Ala Gln Ser Thr Glu Gly
     770                 775                 780                
 Trp Asp Phe Leu Tyr Ser Lys Tyr Gln Phe Ser Leu Ser Ser Thr Glu
 785                 790                 795                 800
 Lys Ser Gln Ile Glu Phe Ala Leu Cys Arg Thr Gln Asn Lys Glu Lys
                 805                 810                 815    
 Leu Gln Trp Leu Leu Asp Glu Ser Phe Lys Gly Asp Lys Ile Lys Thr
             820                 825                 830        
 Gln Glu Phe Pro Gln Ile Leu Thr Leu Ile Gly Arg Asn Pro Val Gly
         835                 840                 845            
 Tyr Pro Leu Ala Trp Gln Phe Leu Arg Lys Asn Trp Asn Lys Leu Val
     850                 855                 860                
 Gln Lys Phe Glu Leu Gly Ser Ser Ser Ile Ala His Met Val Met Gly
 865                 870                 875                 880
 Thr Thr Asn Gln Phe Ser Thr Arg Thr Arg Leu Glu Glu Val Lys Gly
                 885                 890                 895    
 Phe Phe Ser Ser Leu Lys Glu Asn Gly Ser Gln Leu Arg Cys Val Gln
             900                 905                 910        
 Gln Thr Ile Glu Thr Ile Glu Glu Asn Ile Gly Trp Met Asp Lys Asn
         915                 920                 925            
 Phe Asp Lys Ile Arg Val Trp Leu Gln Ser Glu Lys Leu Glu Arg Met
     930                 935                 940                





      <210> 2971
      <211> 445
      <212> PRT
      <213> Homo sapiens


      <400> 2971
 Pro Ser Ser Pro Pro Pro Leu Gly Cys Val Leu Arg Leu Pro Ala Pro
   1               5                  10                  15    
 Pro Arg Pro Gly Ser Arg Ser Gly Cys Gly Arg Thr Ala Leu Arg Gly
              20                  25                  30        
 Arg Pro Leu Gly Ile Gln Arg Ala Arg Ser Ser Leu Val Glu Gly Thr
          35                  40                  45            
 Met Asn Trp His Leu Pro Leu Phe Leu Leu Ala Ser Val Thr Leu Pro
      50                  55                  60                
 Ser Ile Cys Ser His Phe Asn Pro Leu Ser Leu Glu Glu Leu Gly Ser
  65                  70                  75                  80
 Asn Thr Gly Ile Gln Val Phe Asn Gln Ile Val Lys Ser Arg Pro His
                  85                  90                  95    
 Asp Asn Ile Val Ile Ser Pro His Gly Ile Ala Ser Val Leu Gly Met
             100                 105                 110        
 Leu Gln Leu Gly Ala Asp Gly Arg Thr Lys Lys Gln Leu Ala Met Val
         115                 120                 125            
 Met Arg Tyr Gly Val Asn Gly Val Gly Lys Ile Leu Lys Lys Ile Asn
     130                 135                 140                
 Lys Ala Ile Val Ser Lys Lys Asn Lys Asp Ile Val Thr Val Ala Asn
 145                 150                 155                 160
 Ala Val Phe Val Lys Asn Ala Ser Glu Ile Glu Val Pro Phe Val Thr
                 165                 170                 175    
 Arg Asn Lys Asp Val Phe Gln Cys Glu Val Arg Asn Val Asn Phe Glu
             180                 185                 190        
 Asp Pro Ala Ser Ala Cys Asp Ser Ile Asn Ala Trp Val Lys Asn Glu
         195                 200                 205            
 Thr Arg Asp Met Ile Asp Asn Leu Leu Ser Pro Asp Leu Ile Asp Gly
     210                 215                 220                
 Val Leu Thr Arg Leu Val Leu Val Asn Ala Val Tyr Phe Lys Gly Leu
 225                 230                 235                 240
 Trp Lys Ser Arg Phe Gln Pro Glu Asn Thr Lys Lys Arg Thr Phe Val
                 245                 250                 255    
 Ala Ala Asp Gly Lys Ser Tyr Gln Val Pro Met Leu Ala Gln Leu Ser
             260                 265                 270        
 Val Phe Arg Cys Gly Ser Thr Ser Ala Pro Asn Asp Leu Trp Tyr Asn
         275                 280                 285            
 Phe Ile Glu Leu Pro Tyr His Gly Glu Ser Ile Ser Met Leu Ile Ala
     290                 295                 300                
 Leu Pro Thr Glu Ser Ser Thr Pro Leu Ser Ala Ile Ile Pro His Ile
 305                 310                 315                 320
 Ser Thr Lys Thr Ile Asp Ser Trp Met Ser Ile Met Val Pro Lys Arg
                 325                 330                 335    
 Val Gln Val Ile Leu Pro Lys Phe Thr Ala Val Ala Gln Thr Asp Leu
             340                 345                 350        
 Lys Glu Pro Leu Lys Val Leu Gly Ile Thr Asp Met Phe Asp Ser Ser
         355                 360                 365            
 Lys Ala Asn Phe Ala Lys Ile Thr Arg Ser Glu Asn Leu His Val Ser
     370                 375                 380                
 His Ile Leu Gln Lys Ala Lys Ile Glu Val Ser Glu Asp Gly Thr Lys
 385                 390                 395                 400
 Ala Ser Ala Ala Thr Thr Ala Ile Leu Ile Ala Arg Ser Ser Pro Pro
                 405                 410                 415    
 Trp Phe Ile Val Asp Arg Pro Phe Leu Phe Phe Ile Arg His Asn Pro
             420                 425                 430        
 Thr Gly Ala Val Leu Phe Met Gly Gln Ile Asn Lys Pro
         435                 440                 445



      <210> 2972
      <211> 761
      <212> PRT
      <213> Homo sapiens


      <400> 2972
 Ser Arg Pro Ser Cys His Gly Arg Leu Pro Ala Arg Pro Pro Phe Tyr
   1               5                  10                  15    
 Ala Pro Ala His Thr Leu Leu Pro Ser Phe Gln Arg Leu Ser Val Glu
              20                  25                  30        
 His Cys Gly Thr Gln Pro Glu Leu Pro Phe Ser Pro Arg Gly Glu Arg
          35                  40                  45            
 Cys Asp Pro Pro Ala Gly Ala Ala Gly Arg Gly Gly Gly Ala Arg Glu
      50                  55                  60                
 Lys Met Ala Thr Pro Gly Ser Glu Pro Gln Pro Phe Val Pro Ala Leu
  65                  70                  75                  80
 Ser Val Ala Thr Leu His Pro Leu His His Pro His His His His His
                  85                  90                  95    
 His His Gln His His Gly Gly Thr Gly Ala Pro Gly Gly Ala Gly Gly
             100                 105                 110        
 Gly Gly Gly Gly Ser Gly Gly Phe Asn Leu Pro Leu Asn Arg Gly Leu
         115                 120                 125            
 Glu Arg Ala Leu Glu Glu Ala Ala Asn Ser Gly Gly Leu Asn Leu Ser
     130                 135                 140                
 Ala Arg Lys Leu Lys Glu Phe Pro Arg Thr Ala Ala Pro Gly His Asp
 145                 150                 155                 160
 Leu Ser Asp Thr Val Gln Ala Asp Leu Ser Lys Asn Arg Leu Val Glu
                 165                 170                 175    
 Val Pro Met Glu Leu Cys His Phe Val Ser Leu Glu Ile Leu Asn Leu
             180                 185                 190        
 Tyr His Asn Cys Ile Arg Val Ile Pro Glu Ala Ile Val Asn Leu Gln
         195                 200                 205            
 Met Leu Thr Tyr Leu Asn Leu Ser Arg Asn Gln Leu Ser Ala Leu Pro
     210                 215                 220                
 Ala Cys Leu Cys Gly Leu Pro Leu Lys Val Leu Ile Ala Ser Asn Asn
 225                 230                 235                 240
 Lys Leu Gly Ser Leu Pro Glu Glu Ile Gly Gln Leu Lys Gln Leu Met
                 245                 250                 255    
 Glu Leu Asp Val Ser Cys Asn Glu Ile Thr Ala Leu Pro Gln Gln Ile
             260                 265                 270        
 Gly Gln Leu Lys Ser Leu Arg Glu Leu Asn Val Arg Arg Asn Tyr Leu
         275                 280                 285            
 Lys Val Leu Pro Gln Glu Leu Val Asp Leu Pro Leu Val Lys Phe Asp
     290                 295                 300                
 Phe Ser Cys Asn Lys Val Leu Val Ile Pro Ile Cys Phe Arg Glu Met
 305                 310                 315                 320
 Lys Gln Leu Gln Val Leu Leu Leu Glu Asn Asn Pro Leu Gln Ser Pro
                 325                 330                 335    
 Pro Ala Gln Ile Cys Thr Lys Gly Lys Val His Ile Phe Lys Tyr Leu
             340                 345                 350        
 Ser Ile Gln Ala Cys Gln Ile Lys Thr Ala Asp Ser Leu Tyr Leu His
         355                 360                 365            
 Thr Met Glu Arg Pro His Leu His Gln His Val Glu Asp Gly Lys Lys
     370                 375                 380                
 Asp Ser Asp Ser Gly Val Gly Ser Asp Asn Gly Asp Lys Arg Leu Ser
 385                 390                 395                 400
 Ala Thr Glu Pro Ser Asp Glu Asp Thr Val Ser Leu Asn Val Pro Met
                 405                 410                 415    
 Ser Asn Ile Met Glu Glu Glu Gln Ile Ile Lys Glu Asp Ser Cys His
             420                 425                 430        
 Arg Leu Ser Pro Val Lys Gly Glu Phe His Gln Glu Phe Gln Pro Glu
         435                 440                 445            
 Pro Ser Leu Leu Gly Asp Ser Thr Asn Ser Gly Glu Glu Arg Asp Gln
     450                 455                 460                
 Phe Thr Asp Arg Ala Asp Gly Leu His Ser Glu Phe Met Asn Tyr Lys
 465                 470                 475                 480
 Ala Arg Ala Glu Asp Cys Glu Glu Leu Leu Arg Ile Glu Glu Asp Val
                 485                 490                 495    
 His Trp Gln Thr Glu Gly Ile Ile Ser Ser Ser Lys Asp Gln Asp Met
             500                 505                 510        
 Asp Ile Ala Met Ile Glu Gln Leu Arg Glu Ala Val Asp Leu Leu Gln
         515                 520                 525            
 Asp Pro Asn Gly Leu Ser Thr Asp Ile Thr Glu Arg Ser Val Leu Asn
     530                 535                 540                
 Leu Tyr Pro Met Gly Ser Ala Glu Ala Leu Glu Leu Gln Asp Ser Ala
 545                 550                 555                 560
 Leu Asn Gly Gln Ile Gln Leu Glu Thr Ser Pro Val Cys Glu Val Gln
                 565                 570                 575    
 Ser Asp Leu Thr Leu Gln Ser Asn Gly Ser Gln Tyr Ser Pro Asn Glu
             580                 585                 590        
 Ile Arg Glu Asn Ser Pro Ala Val Ser Pro Thr Thr Asn Ser Thr Ala
         595                 600                 605            
 Pro Phe Gly Leu Lys Pro Arg Ser Val Phe Leu Arg Pro Gln Arg Asn
     610                 615                 620                
 Leu Glu Ser Ile Asp Pro Gln Phe Thr Ile Arg Arg Lys Met Glu Gln
 625                 630                 635                 640
 Met Arg Glu Glu Lys Glu Leu Val Glu Gln Leu Arg Glu Ser Ile Glu
                 645                 650                 655    
 Met Arg Leu Lys Val Ser Leu His Glu Asp Leu Gly Ala Ala Leu Met
             660                 665                 670        
 Asp Gly Val Val Leu Cys His Leu Val Asn His Ile Arg Pro Arg Ser
         675                 680                 685            
 Val Ala Ser Ile His Val Pro Ser Pro Ala Val Pro Lys Leu Ser Met
     690                 695                 700                
 Ala Lys Cys Arg Arg Asn Val Glu Asn Phe Leu Glu Ala Cys Arg Lys
 705                 710                 715                 720
 Leu Gly Val Pro Glu Glu Lys Leu Cys Leu Pro His His Ile Leu Glu
                 725                 730                 735    
 Glu Lys Gly Leu Val Lys Val Gly Ile Thr Ile Gln Ala Leu Leu Asp
             740                 745                 750        
 Ile Thr Val Thr Lys Ala Leu Phe Thr
         755                 760    



      <210> 2973
      <211> 188
      <212> PRT
      <213> Homo sapiens


      <400> 2973
 Met Ser Leu Gly Cys Phe Ser Glu Thr Trp Thr Pro Pro Asn Gly Ser
   1               5                  10                  15    
 Val Gly Met Tyr Thr Ser Ala Ile Gln Met Ser Val Phe Ser Phe Ala
              20                  25                  30        
 Ala Leu Gly Gly Gln Thr Glu Val Gln Phe Gly Asn Met Pro Arg Arg
          35                  40                  45            
 Gly Thr Val Ser Ser Asn Glu Arg Ser His Tyr Ser Arg Tyr Gly Gly
      50                  55                  60                
 Gly Ile Thr Val Leu Arg Glu Glu Lys Gly Arg Asn Arg His Ile Asp
  65                  70                  75                  80
 Thr Cys His Cys Val Arg Ile Ala Tyr Ser Val Gln Tyr Ser Asn Met
                  85                  90                  95    
 Leu Cys Arg Glu Arg Val Glu Asn Thr Ser His Pro Gly Glu Met Gln
             100                 105                 110        
 Val Thr Ile Gln Asn Leu Met Pro Ala Thr Val Tyr Ile Phe Arg Val
         115                 120                 125            
 Met Ala Gln Asn Lys His Gly Ser Gly Glu Ser Ser Ala Pro Leu Arg
     130                 135                 140                
 Val Glu Thr Gln Pro Glu Ala Ile Ser Asp Val Phe His Tyr Leu Gln
 145                 150                 155                 160
 Ile Leu Val Leu Pro Asn Thr Thr Thr Leu Leu Ser Ser Ser Ala Asp
                 165                 170                 175    
 Glu Leu Ile Ser Tyr Phe Arg Gly Tyr Ser Ser Arg
             180                 185            



      <210> 2974
      <211> 121
      <212> PRT
      <213> Homo sapiens


      <400> 2974
 Pro Val Thr Val Leu Ala Val Glu Ser Glu Phe Thr Pro Val Pro Ala
   1               5                  10                  15    
 Trp Ser Pro Val Thr Val Leu Ala Val Glu Ser Gly Phe Thr Pro Val
              20                  25                  30        
 Pro Ala Trp Ser Pro Val Thr Val Leu Ala Val Glu Ser Gly Phe Thr
          35                  40                  45            
 Pro Val Pro Ala Trp Ser Pro Val Thr Val Leu Ala Val Gly Ser Glu
      50                  55                  60                
 Phe Thr Pro Val Pro Ala Trp Ser Pro Val Thr Val Leu Ala Val Glu
  65                  70                  75                  80
 Ser Gly Phe Thr Pro Val Pro Ala Trp Ser Pro Val Thr Val Leu Ala
                  85                  90                  95    
 Val Gly Ser Glu Phe Thr Leu Val Pro Ala Trp Phe Pro Val Thr Val
             100                 105                 110        
 Leu Ala Ala Cys Thr Phe Leu Gly Ser
         115                 120    



      <210> 2975
      <211> 61
      <212> PRT
      <213> Homo sapiens


      <400> 2975
 Met His Gly Leu Phe Gly Gln Cys Phe Gln Glu Ala Leu Gly Phe Leu
   1               5                  10                  15    
 Leu Leu Pro Arg Phe Pro Gln Ser Ser Gln Met Leu Lys Phe Leu Lys
              20                  25                  30        
 Val Asp Val Thr Gly Ser Leu Thr Thr Asn Lys Leu Ala Val Thr Val
          35                  40                  45            
 Phe Glu Thr Gln Tyr Leu Trp Gln Leu Thr Ser Asn Gln
      50                  55                  60    



      <210> 2976
      <211> 1245
      <212> PRT
      <213> Homo sapiens


      <400> 2976
 Pro Asn Trp Glu Ala Pro His Ser Arg Gly Arg Leu Thr Pro His Thr
   1               5                  10                  15    
 Ala Gly Tyr Pro Ser Glu Thr Lys Leu Pro Glu Glu Arg Ser Gly Ser
              20                  25                  30        
 Asn Ile Cys Cys Ser Ala Ile Ser Ala Val Leu Gln Pro Leu Leu Leu
          35                  40                  45            
 Ile Pro Arg Gln Thr Gly Ser Gly Val Glu Leu Gln Gln Thr Pro Lys
      50                  55                  60                
 Asp Leu Gln Leu Arg Val Leu Thr Val Arg Arg Lys Thr Asn Lys Gln
  65                  70                  75                  80
 Lys Gly His Pro His Gln Asn Pro Ile Cys Thr Ser Pro Ser Ser Lys
                  85                  90                  95    
 Thr Lys Gly Ser Asn Ser His Ile Thr Ile Leu Thr Leu Asn Val Asn
             100                 105                 110        
 Gly Leu Asn Ala Pro Ile Lys Arg His Arg Leu Ala Asn Trp Ile Lys
         115                 120                 125            
 Ser Gln Asp Pro Ser Val Cys Cys Ile Gln Glu Thr His Leu Thr Cys
     130                 135                 140                
 Arg Asp Thr His Arg Ile Lys Ile Lys Gly Trp Arg Glu Ile Tyr Gln
 145                 150                 155                 160
 Ala Asn Gly Lys Gln Lys Lys Ala Gly Val Ala Ile Leu Val Ser Asp
                 165                 170                 175    
 Lys Thr Asp Phe Lys Pro Thr Lys Ile Lys Arg Asp Lys Glu Gly His
             180                 185                 190        
 Tyr Met Met Val Lys Gly Ser Ile Gln Gln Glu Glu Leu Thr Thr Leu
         195                 200                 205            
 Asn Ile Tyr Ala Pro Asn Thr Gly Ala Pro Arg Phe Ile Lys Gln Val
     210                 215                 220                
 Leu Arg Asp Leu Gln Arg Asp Leu Asp Ser His Thr Leu Ile Met Gly
 225                 230                 235                 240
 Asp Phe Asn Thr Pro Leu Ser Thr Leu Asp Arg Ser Thr Arg Gln Lys
                 245                 250                 255    
 Val Asn Lys Asp Ile Gln Asp Leu Asn Ser Ala Leu His Gln Val Asp
             260                 265                 270        
 Leu Ile Asp Ile Tyr Arg Thr Leu His Pro Lys Ser Thr Glu Tyr Thr
         275                 280                 285            
 Phe Phe Ser Ala Leu His His Ile Tyr Ser Lys Ile Asp His Ile Val
     290                 295                 300                
 Gly Ser Lys Ala Leu Leu Ser Lys Tyr Lys Thr Thr Glu Ile Ile Thr
 305                 310                 315                 320
 Asn Cys Leu Ser Asp His Ser Ala Ile Lys Leu Glu Leu Arg Ile Lys
                 325                 330                 335    
 Lys Leu Thr Gln Asn Arg Ser Thr Thr Trp Lys Leu Asn Asn Leu Leu
             340                 345                 350        
 Leu Asn Asp Tyr Trp Val His Asn Lys Met Lys Ala Glu Ile Asn Thr
         355                 360                 365            
 Leu Phe Glu Thr Asn Glu Asn Lys Asp Thr Thr Tyr Gln Asn Leu Trp
     370                 375                 380                
 Asp Thr Phe Lys Ala Val Cys Arg Arg Lys Phe Ile Ala Leu Asn Ala
 385                 390                 395                 400
 His Lys Arg Lys Gln Glu Arg Ser Lys Ile Asp Thr Leu Thr Ser Gln
                 405                 410                 415    
 Leu Lys Glu Leu Glu Lys Gln Glu Gln Thr His Ser Lys Ala Ser Arg
             420                 425                 430        
 Arg Gln Glu Ile Thr Lys Ile Arg Ala Lys Leu Lys Glu Ile Glu Thr
         435                 440                 445            
 Gln Lys Ile Leu Gln Lys Ile Ser Glu Ser Arg Ser Trp Phe Phe Glu
     450                 455                 460                
 Arg Ile Asn Lys Ile Asp Arg Pro Leu Ala Arg Leu Ile Lys Lys Lys
 465                 470                 475                 480
 Arg Glu Lys Asn Gln Ile Asp Thr Ile Lys Asn Asp Lys Gly Asp Ile
                 485                 490                 495    
 Thr Thr Asp Pro Thr Glu Ile Gln Thr Thr Ile Arg Glu Tyr Tyr Lys
             500                 505                 510        
 His Leu Tyr Ala Asn Lys Leu Glu Asn Leu Glu Glu Met Asp Lys Phe
         515                 520                 525            
 Leu Asp Thr Tyr Thr Leu Pro Arg Leu Asn Gln Glu Glu Val Glu Ser
     530                 535                 540                
 Leu Asn Arg Pro Ile Thr Gly Ala Glu Ile Val Ala Ile Ile Asn Ser
 545                 550                 555                 560
 Leu Pro Pro Pro Thr Thr Ala Arg Gly Pro Gly Pro Asp Gly Phe Thr
                 565                 570                 575    
 Ala Lys Phe Tyr Gln Met Tyr Glu Asn Glu Leu Val Pro Phe Leu Leu
             580                 585                 590        
 Lys Arg Phe Gln Asn Ile Glu Lys Glu Gly Leu Leu Pro Asn Ser Phe
         595                 600                 605            
 Tyr Glu Ala Arg Ile Ile Met Leu Ala Lys Pro Gly Arg Asp Thr Thr
     610                 615                 620                
 Lys Lys Glu Asn Phe Arg Leu Ile Ser Leu Met Lys Ile Gly Ala Lys
 625                 630                 635                 640
 Ile Leu Lys Lys Ile Leu Ala Asn Arg Ile Gln Gln His Ile Lys Lys
                 645                 650                 655    
 Leu Ile His His Asp Gln Val Gly Phe Ile Pro Gly Met Glu Ser Trp
             660                 665                 670        
 Phe Asn Ile Arg Lys Ser Ile Asn Val Ile Gln His Ile Asn Arg Ala
         675                 680                 685            
 Lys Asp Lys Asn His Met Ile Ile Ser Ile Asp Ala Glu Lys Ala Phe
     690                 695                 700                
 Asp Lys Ile Gln Gln Pro Phe Met Leu Lys Thr Leu Asn Lys Leu Gly
 705                 710                 715                 720
 Ile Asp Gly Thr Tyr Phe Lys Ile Ile Arg Ala Ile Tyr Asp Lys Pro
                 725                 730                 735    
 Thr Ala Asn Ile Ile Leu Asn Gly Gln Lys Leu Glu Ala Phe Pro Leu
             740                 745                 750        
 Lys Thr Gly Thr Arg Gln Gly Cys Pro Leu Ser Leu Leu Leu Phe Asn
         755                 760                 765            
 Ile Val Leu Glu Val Leu Ala Arg Ala Ile Arg Gln Glu Lys Glu Ile
     770                 775                 780                
 Lys Gly Ile Gln Leu Gly Lys Glu Glu Val Lys Leu Ala Leu Phe Ala
 785                 790                 795                 800
 Asp Asn Met Ile Val Tyr Leu Glu Asn Pro Ile Ile Ser Ala Gln Asn
                 805                 810                 815    
 Leu Leu Lys Leu Ile Ser Asn Phe Ser Lys Val Ser Gly Tyr Lys Ile
             820                 825                 830        
 Asn Val Gln Lys Ser Gln Ala Phe Leu Tyr Ile Asn Lys Arg Gln Thr
         835                 840                 845            
 Glu Ile Gln Ile Met Ser Glu Leu Pro Phe Thr Thr Ala Ser Lys Arg
     850                 855                 860                
 Ile Lys Tyr Leu Gly Thr Gln Ile Thr Arg Asp Val Lys Asp Leu Phe
 865                 870                 875                 880
 Lys Glu Asp Tyr Lys Gln Leu Leu Asn Lys Ile Lys Glu Asp Thr Asn
                 885                 890                 895    
 Lys Leu Lys Asn Ile Pro Cys Ser Trp Ile Gly Arg Ile Asn Ile Met
             900                 905                 910        
 Arg Met Gly Arg Leu Pro Lys Val Ile Tyr Arg Phe Asn Ala Ile Pro
         915                 920                 925            
 Ile Lys Leu Pro Met Thr Phe Leu Thr Glu Leu Glu Lys Thr Thr Leu
     930                 935                 940                
 Lys Phe Ile Trp Asn Gln Lys Arg Ala Arg Ile Ala Lys Ser Ile Leu
 945                 950                 955                 960
 Ser Gln Lys Asn Lys Ala Gly Gly Ile Thr Leu Pro Asp Phe Lys Leu
                 965                 970                 975    
 Tyr Tyr Lys Ala Thr Val Thr Lys Thr Ala Trp Tyr Trp Tyr Gln Lys
             980                 985                 990        
 Arg Asp Ile His Gln Trp Asn Thr Thr Glu Pro Ser Glu Ile Thr Pro
         995                1000                1005            
 His Ile Tyr Asn His Leu Ile Phe Asp Lys Pro Glu Lys Asn Lys Gln
    1010                1015                1020                
 Trp Gly Lys Asp Ser Leu Phe Asn Lys Trp Cys Trp Glu Asn Trp Leu
1025                1030                1035                1040
 Ala Ile Trp Arg Lys Leu Lys Leu Asp Pro Phe Leu Thr Pro Tyr Thr
                1045                1050                1055    
 Lys Ile Asn Ser Arg Trp Ile Lys Asp Leu Asn Val Arg Pro Lys Thr
            1060                1065                1070        
 Ile Lys Thr Leu Glu Glu Asn Leu Gly Ile Thr Ile Gln Asp Ile Gly
        1075                1080                1085            
 Met Gly Lys Asp Phe Met Ser Lys Thr Pro Lys Ala Met Ala Thr Lys
    1090                1095                1100                
 Ala Lys Ile Asp Lys Trp Asp Leu Ile Lys Leu Lys Ser Phe Cys Thr
1105                1110                1115                1120
 Ala Lys Glu Thr Thr Thr Ile Arg Val Asn Arg Gln Pro Thr Lys Trp
                1125                1130                1135    
 Glu Lys Ile Phe Thr Thr Tyr Ser Ser Asp Lys Gly Leu Ile Ser Arg
            1140                1145                1150        
 Ile Tyr Asn Glu Leu Lys Gln Ile Tyr Lys Lys Lys Ser Asp Asn Pro
        1155                1160                1165            
 Ile Lys Lys Trp Val Lys Asp Met Asn Arg His Phe Ser Lys Glu Asp
    1170                1175                1180                
 Ile Tyr Ala Ala Lys Lys His Met Lys Lys Cys Ser Pro Ser Leu Ala
1185                1190                1195                1200
 Ile Arg Glu Met Gln Ile Lys Thr Thr Met Arg Tyr His Leu Thr Pro
                1205                1210                1215    
 Pro Pro Leu Leu Ile Pro Arg Gln Thr Gly Ser Gly Val Asp Leu Trp
            1220                1225                1230        
 Arg Thr Pro Asn Arg Pro Ala Ala Glu Gly Pro Asp Cys
        1235                1240                1245



      <210> 2977
      <211> 3173
      <212> PRT
      <213> Homo sapiens


      <400> 2977
 Gly Arg Phe Leu Ser Lys Leu Phe Phe Ser Ile Ser Ser Gln Lys Thr
   1               5                  10                  15    
 Cys Leu His Leu His Gly Ile Phe Pro Tyr Leu Tyr Val Pro Tyr Asp
              20                  25                  30        
 Gly Tyr Gly Gln Gln Pro Glu Ser Tyr Leu Ser Gln Met Ala Phe Ser
          35                  40                  45            
 Ile Asp Arg Ala Leu Asn Val Ala Leu Gly Asn Pro Ser Ser Thr Ala
      50                  55                  60                
 Gln His Val Phe Lys Val Ser Leu Val Ser Gly Met Pro Phe Tyr Gly
  65                  70                  75                  80
 Tyr His Glu Lys Glu Arg His Phe Met Lys Ile Tyr Leu Tyr Asn Pro
                  85                  90                  95    
 Thr Met Val Lys Arg Ile Cys Glu Leu Leu Gln Ser Gly Ala Ile Met
             100                 105                 110        
 Asn Lys Phe Tyr Gln Pro His Glu Ala His Ile Pro Tyr Leu Leu Gln
         115                 120                 125            
 Leu Phe Ile Asp Tyr Asn Leu Tyr Gly Met Asn Leu Ile Asn Leu Ala
     130                 135                 140                
 Ala Val Lys Phe Arg Lys Ala Arg Arg Lys Ser Asn Thr Leu His Ala
 145                 150                 155                 160
 Thr Gly Ser Cys Lys Asn His Leu Ser Gly Asn Ser Leu Ala Asp Thr
                 165                 170                 175    
 Leu Phe Arg Trp Glu Gln Asp Glu Ile Pro Ser Ser Leu Ile Leu Glu
             180                 185                 190        
 Gly Val Glu Pro His Ser Thr Cys Glu Leu Gln Val Asp Ala Val Ala
         195                 200                 205            
 Ala Asp Ile Leu Asn Arg Leu Asp Ile Glu Ala Gln Ile Gly Gly Asn
     210                 215                 220                
 Pro Gly Leu Gln Ala Ile Trp Glu Asp Glu Lys Gln Arg Arg Arg Asn
 225                 230                 235                 240
 Arg Asn Glu Thr Ser Gln Met Ser Gln Pro Glu Ser Gln Asp His Arg
                 245                 250                 255    
 Phe Val Pro Ala Thr Glu Ser Glu Lys Lys Phe Gln Lys Arg Leu Gln
             260                 265                 270        
 Glu Ile Leu Lys Gln Asn Asp Phe Ser Val Thr Leu Ser Gly Ser Val
         275                 280                 285            
 Asp Tyr Ser Asp Gly Ser Gln Glu Phe Ser Ala Glu Leu Thr Leu His
     290                 295                 300                
 Ser Glu Val Leu Ser Pro Glu Met Leu Gln Cys Thr Pro Ala Asn Met
 305                 310                 315                 320
 Val Glu Val His Lys Asp Lys Glu Ser Ser Lys Gly His Thr Arg His
                 325                 330                 335    
 Lys Val Glu Glu Ala Leu Ile Asn Glu Glu Ala Ile Leu Asn Leu Met
             340                 345                 350        
 Glu Asn Ser Gln Thr Phe Gln Pro Leu Thr Gln Arg Leu Ser Glu Ser
         355                 360                 365            
 Pro Val Phe Met Asp Ser Ser Pro Asp Glu Ala Leu Val His Leu Leu
     370                 375                 380                
 Ala Gly Leu Glu Ser Asp Gly Tyr Arg Gly Glu Arg Asn Arg Met Pro
 385                 390                 395                 400
 Ser Pro Cys Arg Ser Phe Gly Asn Asn Lys Tyr Pro Gln Asn Ser Asp
                 405                 410                 415    
 Asp Glu Glu Asn Glu Pro Gln Ile Glu Lys Glu Glu Met Glu Leu Ser
             420                 425                 430        
 Leu Val Met Ser Gln Arg Trp Asp Ser Asn Ile Glu Glu His Cys Ala
         435                 440                 445            
 Lys Lys Arg Ser Leu Cys Arg Asn Thr His Arg Ser Ser Thr Glu Asp
     450                 455                 460                
 Asp Asp Ser Ser Ser Gly Glu Glu Met Glu Trp Ser Asp Asn Ser Leu
 465                 470                 475                 480
 Leu Leu Ala Ser Leu Ser Ile Pro Gln Leu Asp Gly Thr Ala Asp Glu
                 485                 490                 495    
 Asn Ser Asp Asn Pro Leu Asn Asn Glu Asn Ser Arg Thr His Ser Ser
             500                 505                 510        
 Val Ile Ala Thr Ser Lys Leu Ser Val Lys Pro Ser Ile Phe His Lys
         515                 520                 525            
 Asp Ala Ala Thr Leu Glu Pro Ser Ser Ser Ala Lys Ile Thr Phe Gln
     530                 535                 540                
 Cys Lys His Thr Ser Ala Leu Ser Ser His Val Leu Asn Lys Glu Asp
 545                 550                 555                 560
 Leu Ile Glu Asp Leu Ser Gln Thr Asn Lys Asn Thr Glu Lys Gly Leu
                 565                 570                 575    
 Asp Asn Ser Val Thr Ser Phe Thr Asn Glu Ser Thr Tyr Ser Met Lys
             580                 585                 590        
 Tyr Pro Gly Ser Leu Ser Ser Thr Val His Ser Glu Asn Ser His Lys
         595                 600                 605            
 Glu Asn Ser Lys Lys Glu Ile Leu Pro Val Ser Ser Cys Glu Ser Ser
     610                 615                 620                
 Ile Phe Asp Tyr Glu Glu Asp Ile Pro Ser Val Thr Arg Gln Val Pro
 625                 630                 635                 640
 Ser Arg Lys Tyr Thr Asn Ile Arg Lys Ile Glu Lys Asp Ser Pro Phe
                 645                 650                 655    
 Ile His Met His Arg His Pro Asn Glu Asn Thr Leu Gly Lys Asn Ser
             660                 665                 670        
 Phe Asn Phe Ser Asp Leu Asn His Ser Lys Asn Lys Val Ser Ser Glu
         675                 680                 685            
 Gly Asn Glu Lys Gly Asn Ser Thr Ala Leu Ser Ser Leu Phe Pro Ser
     690                 695                 700                
 Ser Phe Thr Glu Asn Cys Glu Leu Leu Ser Cys Ser Gly Glu Asn Arg
 705                 710                 715                 720
 Thr Met Val His Ser Leu Asn Ser Thr Ala Asp Glu Ser Gly Leu Asn
                 725                 730                 735    
 Lys Leu Lys Ile Arg Tyr Glu Glu Phe Gln Glu His Lys Thr Glu Lys
             740                 745                 750        
 Pro Ser Leu Ser Gln Gln Ala Ala His Tyr Met Phe Phe Pro Ser Val
         755                 760                 765            
 Val Leu Ser Asn Cys Leu Thr Arg Pro Gln Lys Leu Ser Pro Val Thr
     770                 775                 780                
 Tyr Lys Leu Gln Pro Gly Asn Lys Pro Ser Arg Leu Lys Leu Asn Lys
 785                 790                 795                 800
 Arg Lys Leu Ala Gly His Gln Glu Thr Ser Thr Lys Ser Ser Glu Thr
                 805                 810                 815    
 Gly Ser Thr Lys Asp Asn Phe Ile Gln Asn Asn Pro Cys Asn Ser Asn
             820                 825                 830        
 Pro Glu Lys Asp Asn Ala Leu Ala Ser Asp Leu Thr Lys Thr Thr Arg
         835                 840                 845            
 Gly Ala Phe Glu Asn Lys Thr Pro Thr Asp Gly Phe Ile Asp Cys His
     850                 855                 860                
 Phe Gly Asp Gly Thr Leu Glu Thr Glu Gln Ser Phe Gly Leu Tyr Gly
 865                 870                 875                 880
 Asn Lys Tyr Thr Leu Arg Ala Lys Arg Lys Val Asn Tyr Glu Thr Glu
                 885                 890                 895    
 Asp Ser Glu Ser Ser Phe Val Thr His Asn Ser Lys Ile Ser Leu Pro
             900                 905                 910        
 His Pro Met Glu Ile Gly Glu Ser Leu Asp Gly Thr Leu Lys Ser Arg
         915                 920                 925            
 Lys Arg Arg Lys Met Ser Lys Lys Leu Pro Pro Val Ile Ile Lys Tyr
     930                 935                 940                
 Ile Ile Ile Asn Arg Phe Arg Gly Arg Lys Asn Met Leu Val Lys Leu
 945                 950                 955                 960
 Gly Lys Ile Asp Ser Lys Glu Lys Gln Val Ile Leu Thr Glu Glu Lys
                 965                 970                 975    
 Met Glu Leu Tyr Lys Lys Leu Ala Pro Leu Lys Asp Phe Trp Pro Lys
             980                 985                 990        
 Val Pro Asp Ser Pro Ala Thr Lys Tyr Pro Ile Tyr Pro Leu Thr Pro
         995                1000                1005            
 Lys Lys Ser His Arg Arg Lys Ser Lys His Lys Ser Ala Lys Lys Lys
    1010                1015                1020                
 Thr Gly Lys Gln Gln Arg Thr Asn Asn Glu Asn Ile Lys Arg Thr Leu
1025                1030                1035                1040
 Ser Phe Arg Lys Lys Arg Ser His Ala Ile Leu Ser Pro Pro Ser Pro
                1045                1050                1055    
 Ser Tyr Asn Ala Glu Thr Glu Asp Cys Asp Leu Asn Tyr Ser Asp Val
            1060                1065                1070        
 Met Ser Lys Leu Gly Phe Leu Ser Glu Arg Ser Thr Ser Pro Ile Asn
        1075                1080                1085            
 Ser Ser Pro Pro Arg Cys Trp Ser Pro Thr Asp Pro Arg Ala Glu Glu
    1090                1095                1100                
 Ile Met Ala Ala Ala Glu Lys Glu Ala Met Leu Phe Lys Gly Pro Asn
1105                1110                1115                1120
 Val Cys Lys Lys Thr Val Asn Ser Arg Ile Gly Lys Thr Ser Arg Ala
                1125                1130                1135    
 Arg Ala Gln Ile Lys Lys Ser Lys Ala Lys Leu Ala Asn Pro Ser Ile
            1140                1145                1150        
 Val Thr Lys Lys Arg Asn Lys Arg Asn Gln Thr Asn Lys Leu Val Asp
        1155                1160                1165            
 Asp Gly Lys Lys Lys Pro Arg Ala Lys Gln Lys Thr Asn Glu Lys Gly
    1170                1175                1180                
 Thr Ser Arg Lys His Ile Thr Leu Lys Asp Glu Lys Ile Lys Ser Gln
1185                1190                1195                1200
 Ser Gly Ala Glu Val Lys Phe Val Leu Lys His Gln Asn Val Ser Glu
                1205                1210                1215    
 Phe Ala Ser Ser Ser Gly Gly Ser Gln Leu Leu Phe Lys Gln Lys Asp
            1220                1225                1230        
 Met Pro Leu Met Gly Ser Ala Val Asp His Pro Leu Ser Ala Ser Leu
        1235                1240                1245            
 Pro Thr Gly Ile Asn Ala Gln Gln Lys Leu Ser Gly Cys Phe Ser Ser
    1250                1255                1260                
 Phe Leu Glu Ser Lys Lys Ser Val Asp Leu Gln Thr Phe Pro Ser Ser
1265                1270                1275                1280
 Arg Asp Asp Leu His Pro Ser Val Val Cys Asn Ser Ile Gly Pro Gly
                1285                1290                1295    
 Val Ser Lys Ile Asn Val Gln Arg Pro His Asn Gln Ser Ala Met Phe
            1300                1305                1310        
 Thr Leu Lys Glu Ser Thr Leu Ile Gln Lys Asn Ile Phe Asp Leu Ser
        1315                1320                1325            
 Asn His Leu Ser Gln Val Ala Gln Asn Thr Gln Ile Ser Ser Gly Met
    1330                1335                1340                
 Ser Ser Lys Ile Glu Asp Asn Ala Asn Asn Ile Gln Arg Asn Tyr Leu
1345                1350                1355                1360
 Ser Ser Ile Gly Lys Leu Ser Glu Tyr Arg Asn Ser Leu Glu Ser Lys
                1365                1370                1375    
 Leu Asp Gln Ala Tyr Thr Pro Asn Phe Leu His Cys Lys Asp Ser Gln
            1380                1385                1390        
 Gln Gln Ile Val Cys Ile Ala Glu Gln Ser Lys His Ser Glu Thr Cys
        1395                1400                1405            
 Ser Pro Gly Asn Thr Ala Ser Glu Glu Ser Gln Met Pro Asn Asn Cys
    1410                1415                1420                
 Phe Val Thr Ser Leu Arg Ser Pro Ile Lys Gln Ile Ala Trp Glu Gln
1425                1430                1435                1440
 Lys Gln Arg Gly Phe Ile Leu Asp Met Ser Asn Phe Lys Pro Glu Arg
                1445                1450                1455    
 Val Lys Pro Arg Ser Leu Ser Glu Ala Ile Ser Gln Thr Lys Ala Leu
            1460                1465                1470        
 Ser Gln Cys Lys Asn Arg Asn Val Ser Thr Pro Ser Ala Phe Gly Glu
        1475                1480                1485            
 Gly Gln Ser Gly Leu Ala Val Leu Lys Glu Leu Leu Gln Lys Arg Gln
    1490                1495                1500                
 Gln Glu Ala Gln Asn Ala Asn Thr Thr Gln Asp Pro Leu Ser Asn Lys
1505                1510                1515                1520
 His Gln Pro Asn Lys Asn Ile Ser Gly Ser Leu Glu His Asn Lys Ala
                1525                1530                1535    
 Asn Lys Arg Thr Arg Ser Val Thr Ser Pro Arg Lys Pro Arg Thr Pro
            1540                1545                1550        
 Arg Ser Thr Lys Gln Lys Glu Lys Ile Pro Lys Leu Leu Lys Val Asp
        1555                1560                1565            
 Ser Leu Asn Leu Gln Asn Ser Ser Gln Leu Asp Asn Ser Val Ser Asp
    1570                1575                1580                
 Asp Ser Pro Ile Phe Phe Ser Asp Pro Gly Phe Glu Ser Cys Tyr Ser
1585                1590                1595                1600
 Leu Glu Asp Ser Leu Ser Pro Glu His Asn Tyr Asn Phe Asp Ile Asn
                1605                1610                1615    
 Thr Ile Gly Gln Thr Gly Phe Cys Ser Phe Tyr Ser Gly Ser Gln Phe
            1620                1625                1630        
 Val Pro Ala Asp Gln Asn Leu Pro Gln Lys Phe Leu Ser Asp Ala Val
        1635                1640                1645            
 Gln Asp Leu Phe Pro Gly Gln Ala Ile Glu Lys Asn Glu Phe Leu Ser
    1650                1655                1660                
 His Asp Asn Gln Lys Cys Asp Glu Asp Lys His His Thr Thr Asp Ser
1665                1670                1675                1680
 Ala Ser Trp Ile Arg Ser Gly Thr Leu Ser Pro Glu Ile Phe Glu Lys
                1685                1690                1695    
 Ser Thr Ile Asp Ser Asn Glu Asn Arg Arg His Asn Gln Trp Lys Asn
            1700                1705                1710        
 Ser Phe His Pro Leu Thr Thr Arg Ser Asn Ser Ile Met Asp Ser Phe
        1715                1720                1725            
 Cys Val Gln Gln Ala Glu Asp Cys Leu Ser Glu Lys Ser Arg Leu Asn
    1730                1735                1740                
 Arg Ser Ser Val Ser Lys Glu Val Phe Leu Ser Leu Pro Gln Pro Asn
1745                1750                1755                1760
 Asn Ser Asp Trp Ile Gln Gly His Thr Arg Lys Glu Met Gly Gln Ser
                1765                1770                1775    
 Leu Asp Ser Ala Asn Thr Ser Phe Thr Ala Ile Leu Ser Ser Pro Asp
            1780                1785                1790        
 Gly Glu Leu Val Asp Val Ala Cys Glu Asp Leu Glu Leu Tyr Val Ser
        1795                1800                1805            
 Arg Asn Asn Asp Met Leu Thr Pro Thr Pro Asp Ser Ser Pro Arg Ser
    1810                1815                1820                
 Thr Ser Ser Pro Ser Gln Ser Lys Asn Gly Ser Phe Thr Pro Arg Thr
1825                1830                1835                1840
 Ala Asn Ile Leu Lys Pro Leu Met Ser Pro Pro Ser Arg Glu Glu Ile
                1845                1850                1855    
 Met Ala Thr Leu Leu Asp His Asp Leu Ser Glu Thr Ile Tyr Gln Glu
            1860                1865                1870        
 Pro Phe Cys Ser Asn Pro Ser Asp Val Pro Glu Lys Pro Arg Glu Ile
        1875                1880                1885            
 Gly Gly Arg Leu Leu Met Val Glu Thr Arg Leu Ala Asn Asp Leu Ala
    1890                1895                1900                
 Glu Phe Glu Gly Asp Phe Ser Leu Glu Gly Leu Arg Leu Trp Lys Thr
1905                1910                1915                1920
 Ala Phe Ser Ala Met Thr Gln Asn Pro Arg Pro Gly Ser Pro Leu Arg
                1925                1930                1935    
 Ser Gly Gln Gly Val Val Asn Lys Gly Ser Ser Asn Ser Pro Lys Met
            1940                1945                1950        
 Val Glu Asp Lys Lys Ile Val Ile Met Pro Cys Lys Cys Ala Pro Ser
        1955                1960                1965            
 Arg Gln Leu Val Gln Val Trp Leu Gln Ala Lys Glu Glu Tyr Glu Arg
    1970                1975                1980                
 Ser Lys Lys Leu Pro Lys Thr Lys Pro Thr Gly Val Val Lys Ser Ala
1985                1990                1995                2000
 Glu Asn Phe Ser Ser Ser Val Asn Pro Asp Asp Lys Pro Val Val Pro
                2005                2010                2015    
 Pro Lys Met Asp Val Ser Pro Cys Ile Leu Pro Thr Thr Ala His Thr
            2020                2025                2030        
 Lys Glu Asp Val Asp Asn Ser Gln Ile Ala Leu Gln Ala Pro Thr Thr
        2035                2040                2045            
 Gly Cys Ser Gln Thr Ala Ser Glu Ser Gln Met Leu Pro Pro Val Ala
    2050                2055                2060                
 Ser Ala Ser Asp Pro Glu Lys Asp Glu Asp Asp Asp Asp Asn Tyr Tyr
2065                2070                2075                2080
 Ile Ser Tyr Ser Ser Pro Asp Ser Pro Val Ile Pro Pro Trp Gln Gln
                2085                2090                2095    
 Pro Ile Ser Pro Asp Ser Lys Ala Leu Asn Gly Asp Asp Arg Pro Ser
            2100                2105                2110        
 Ser Pro Val Glu Glu Leu Pro Ser Leu Ala Phe Glu Asn Phe Leu Lys
        2115                2120                2125            
 Pro Ile Lys Asp Gly Ile Gln Lys Ser Pro Cys Ser Glu Pro Gln Glu
    2130                2135                2140                
 Pro Leu Val Ile Ser Pro Ile Asn Thr Arg Ala Arg Thr Gly Lys Cys
2145                2150                2155                2160
 Glu Ser Leu Cys Phe His Ser Thr Pro Ile Ile Gln Arg Lys Leu Leu
                2165                2170                2175    
 Glu Arg Leu Pro Glu Ala Pro Gly Leu Ser Pro Leu Ser Thr Glu Pro
            2180                2185                2190        
 Lys Thr Gln Lys Leu Ser Asn Lys Lys Gly Ser Asn Thr Asp Thr Leu
        2195                2200                2205            
 Arg Arg Val Leu Leu Thr Gln Ala Lys Asn Gln Phe Ala Ala Val Asn
    2210                2215                2220                
 Thr Pro Gln Lys Glu Thr Ser Gln Ile Asp Gly Pro Ser Leu Asn Asn
2225                2230                2235                2240
 Thr Tyr Gly Phe Lys Val Ser Ile Gln Asn Leu Gln Glu Ala Lys Ala
                2245                2250                2255    
 Leu His Glu Ile Gln Asn Leu Thr Leu Ile Ser Val Glu Leu His Ala
            2260                2265                2270        
 Arg Thr Arg Arg Asp Leu Glu Pro Asp Pro Glu Phe Asp Pro Ile Cys
        2275                2280                2285            
 Ala Leu Phe Tyr Cys Ile Ser Ser Asp Thr Pro Leu Pro Asp Thr Glu
    2290                2295                2300                
 Lys Thr Glu Leu Thr Gly Val Ile Val Ile Asp Lys Asp Lys Thr Val
2305                2310                2315                2320
 Phe Ser Gln Asp Ile Arg Tyr Gln Thr Pro Leu Leu Ile Arg Ser Gly
                2325                2330                2335    
 Ile Thr Gly Leu Glu Val Thr Tyr Ala Ala Asp Glu Lys Ala Leu Phe
            2340                2345                2350        
 His Glu Ile Ala Asn Ile Ile Lys Arg Tyr Asp Pro Asp Ile Leu Leu
        2355                2360                2365            
 Gly Tyr Glu Ile Gln Met His Ser Trp Gly Tyr Leu Leu Gln Arg Ala
    2370                2375                2380                
 Ala Ala Leu Ser Ile Asp Leu Cys Arg Met Ile Ser Arg Val Pro Asp
2385                2390                2395                2400
 Asp Lys Ile Glu Asn Arg Phe Ala Ala Glu Arg Asp Glu Tyr Gly Ser
                2405                2410                2415    
 Tyr Thr Met Ser Glu Ile Asn Ile Val Gly Arg Ile Thr Leu Asn Leu
            2420                2425                2430        
 Trp Arg Ile Met Arg Asn Glu Val Ala Leu Thr Asn Tyr Thr Phe Glu
        2435                2440                2445            
 Asn Val Ser Phe His Val Leu His Gln Arg Phe Pro Leu Phe Thr Phe
    2450                2455                2460                
 Arg Val Leu Ser Asp Trp Phe Asp Asn Lys Thr Asp Leu Tyr Arg Trp
2465                2470                2475                2480
 Lys Met Val Asp His Tyr Val Ser Arg Val Arg Gly Asn Leu Gln Met
                2485                2490                2495    
 Leu Glu Gln Leu Asp Leu Ile Gly Lys Thr Ser Glu Met Ala Arg Leu
            2500                2505                2510        
 Phe Gly Ile Gln Phe Leu His Val Leu Thr Arg Gly Ser Gln Tyr Arg
        2515                2520                2525            
 Val Glu Ser Met Met Leu Arg Ile Ala Lys Pro Met Asn Tyr Ile Pro
    2530                2535                2540                
 Val Thr Pro Ser Val Gln Gln Arg Ser Gln Met Arg Ala Pro Gln Cys
2545                2550                2555                2560
 Val Pro Leu Ile Met Glu Pro Glu Ser Arg Phe Tyr Ser Asn Ser Val
                2565                2570                2575    
 Leu Val Leu Asp Phe Gln Ser Leu Tyr Pro Ser Ile Val Ile Ala Tyr
            2580                2585                2590        
 Asn Tyr Cys Phe Ser Thr Cys Leu Gly His Val Glu Asn Leu Gly Lys
        2595                2600                2605            
 Tyr Asp Glu Phe Lys Phe Gly Cys Thr Ser Leu Arg Val Pro Pro Asp
    2610                2615                2620                
 Leu Leu Tyr Gln Val Arg His Asp Ile Thr Val Ser Pro Asn Gly Val
2625                2630                2635                2640
 Ala Phe Val Lys Pro Ser Val Arg Lys Gly Val Leu Pro Arg Met Leu
                2645                2650                2655    
 Glu Glu Ile Leu Lys Thr Arg Phe Met Val Lys Gln Ser Met Lys Ala
            2660                2665                2670        
 Tyr Lys Gln Asp Arg Ala Leu Ser Arg Met Leu Asp Ala Arg Gln Leu
        2675                2680                2685            
 Gly Leu Lys Leu Ile Ala Asn Val Thr Phe Gly Tyr Thr Ser Ala Asn
    2690                2695                2700                
 Phe Ser Gly Arg Met Pro Cys Ile Glu Val Gly Asp Ser Ile Val His
2705                2710                2715                2720
 Lys Ala Arg Glu Thr Leu Glu Arg Ala Ile Lys Leu Val Asn Asp Thr
                2725                2730                2735    
 Lys Lys Trp Gly Ala Arg Val Val Tyr Gly Asp Thr Asp Ser Met Phe
            2740                2745                2750        
 Val Leu Leu Lys Gly Ala Thr Lys Glu Gln Ser Phe Lys Ile Gly Gln
        2755                2760                2765            
 Glu Ile Ala Glu Ala Val Thr Ala Thr Asn Pro Lys Pro Val Lys Leu
    2770                2775                2780                
 Lys Phe Glu Lys Val Tyr Leu Pro Cys Val Leu Gln Thr Lys Lys Arg
2785                2790                2795                2800
 Tyr Val Gly Tyr Met Tyr Glu Thr Leu Asp Gln Lys Asp Pro Val Phe
                2805                2810                2815    
 Asp Ala Lys Gly Ile Glu Thr Val Arg Arg Asp Ser Cys Pro Ala Val
            2820                2825                2830        
 Ser Lys Ile Leu Glu Arg Ser Leu Lys Leu Leu Phe Glu Thr Arg Asp
        2835                2840                2845            
 Ile Ser Leu Ile Lys Gln Tyr Val Gln Arg Gln Cys Met Lys Leu Leu
    2850                2855                2860                
 Glu Gly Lys Ala Ser Ile Gln Asp Phe Ile Phe Ala Lys Glu Tyr Arg
2865                2870                2875                2880
 Gly Ser Phe Ser Tyr Lys Pro Gly Ala Cys Val Pro Ala Leu Glu Leu
                2885                2890                2895    
 Thr Arg Lys Met Leu Thr Tyr Asp Arg Arg Ser Glu Pro Gln Val Gly
            2900                2905                2910        
 Glu Arg Val Pro Tyr Val Ile Ile Tyr Gly Thr Pro Gly Val Pro Leu
        2915                2920                2925            
 Ile Gln Leu Val Arg Arg Pro Val Glu Val Leu Gln Asp Pro Thr Leu
    2930                2935                2940                
 Arg Leu Asn Ala Thr Tyr Tyr Ile Thr Lys Gln Ile Leu Pro Pro Leu
2945                2950                2955                2960
 Ala Arg Ile Phe Ser Leu Ile Gly Ile Asp Val Phe Ser Trp Tyr His
                2965                2970                2975    
 Glu Leu Pro Arg Gly Phe Ile Ala Ala Leu Phe Thr Ile Ala Lys Thr
            2980                2985                2990        
 Trp Asn Gln Pro Lys Cys Pro Ser Met Ile Asp Trp Ile Lys Lys Met
        2995                3000                3005            
 Trp His Ile Tyr Thr Met Glu Tyr Tyr Ala Ala Ile Lys Lys Asp Glu
    3010                3015                3020                
 Phe Met Ser Phe Ala Gly Thr Trp Met Lys Leu Glu Thr Ile Ile Leu
3025                3030                3035                3040
 Ser Lys Leu Ser Gln Gly Gln Lys Thr Lys His Arg Leu Phe Ser Leu
                3045                3050                3055    
 Ile Ile His Lys Ala Thr Ser Pro Ser Arg Ser Glu Pro Glu Gly Arg
            3060                3065                3070        
 Lys Gly Thr Ile Ser Gln Tyr Phe Thr Thr Leu His Cys Pro Val Cys
        3075                3080                3085            
 Asp Asp Leu Thr Gln His Gly Ile Cys Ser Lys Cys Arg Ser Gln Pro
    3090                3095                3100                
 Gln His Val Ala Val Ile Leu Asn Gln Glu Ile Arg Glu Leu Glu Arg
3105                3110                3115                3120
 Gln Gln Glu Gln Leu Val Lys Ile Cys Lys Asn Cys Thr Gly Cys Phe
                3125                3130                3135    
 Asp Arg His Ile Pro Cys Val Ser Leu Asn Cys Pro Val Leu Phe Lys
            3140                3145                3150        
 Leu Ser Arg Val Asn Arg Glu Leu Ser Lys Ala Pro Tyr Leu Arg Gln
        3155                3160                3165            
 Leu Leu Asp Gln Phe
    3170            



      <210> 2978
      <211> 217
      <212> PRT
      <213> Homo sapiens


      <400> 2978
 Gln Gln His Leu Pro Ile Leu Lys Gln Trp Leu His Ala Ser Asp Val
   1               5                  10                  15    
 Gly Phe Arg Phe Thr Met Asp Ala Asp Lys Glu Lys Asp Leu Gln Lys
              20                  25                  30        
 Phe Leu Lys Asn Val Asp Glu Ile Ser Leu Lys Glu Lys Gly Asn Glu
          35                  40                  45            
 Ala Phe Ala Glu Gly Asn Tyr Glu Thr Ala Ile Leu Arg Tyr Ser Glu
      50                  55                  60                
 Gly Leu Glu Lys Leu Lys Asp Met Lys Val Leu Tyr Thr Asn Arg Ala
  65                  70                  75                  80
 Gln Ala Tyr Met Lys Leu Glu Asp Tyr Glu Lys Ala Leu Val Asp Cys
                  85                  90                  95    
 Glu Trp Ala Leu Lys Cys Asp Glu Lys Cys Thr Lys Ala Tyr Phe His
             100                 105                 110        
 Met Gly Lys Ala Asn Leu Ala Leu Lys Asn Tyr Ser Val Ser Arg Glu
         115                 120                 125            
 Cys Tyr Lys Lys Ile Leu Glu Ile Asn Pro Lys Leu Gln Thr Gln Val
     130                 135                 140                
 Lys Val Tyr Leu Asn Gln Val Asp Leu Gln Glu Lys Ala Asp Leu Gln
 145                 150                 155                 160
 Glu Lys Glu Ala His Glu Leu Leu Asp Ser Gly Lys Asn Thr Ala Val
                 165                 170                 175    
 Thr Thr Lys Asn Leu Leu Glu Thr Leu Ser Lys Pro Asp Gln Ile Pro
             180                 185                 190        
 Leu Phe Tyr Ala Gly Gly Ile Glu Ile Leu Thr Glu Met Ile Asn Glu
         195                 200                 205            
 Cys Lys Pro Glu Met Cys Val Ile Ser
     210                 215        



      <210> 2979
      <211> 819
      <212> PRT
      <213> Homo sapiens


      <400> 2979
 Ala Gly Phe Asn His Gly Phe Asn Cys Ala Glu Ser Thr Asn Phe Ala
   1               5                  10                  15    
 Thr Leu Arg Trp Ile Asp Tyr Gly Lys Val Ala Thr Gln Cys Thr Cys
              20                  25                  30        
 Arg Lys Asp Met Val Lys Ile Ser Met Asp Val Phe Val Arg Ile Leu
          35                  40                  45            
 Gln Pro Glu Arg Tyr Glu Leu Trp Lys Gln Gly Lys Asp Leu Thr Val
      50                  55                  60                
 Leu Asp His Thr Arg Pro Thr Ala Leu Thr Ser Pro Glu Leu Ser Ser
  65                  70                  75                  80
 Trp Ser Ala Ser Arg Ala Ser Leu Lys Ala Lys Leu Leu Arg Arg Ser
                  85                  90                  95    
 His Arg Lys Arg Ser Gln Pro Lys Lys Pro Lys Pro Glu Asp Pro Lys
             100                 105                 110        
 Phe Pro Gly Glu Gly Thr Ala Gly Ala Ala Leu Leu Glu Glu Ala Gly
         115                 120                 125            
 Gly Ser Val Lys Glu Glu Ala Gly Pro Glu Val Asp Pro Glu Glu Glu
     130                 135                 140                
 Glu Glu Glu Pro Gln Pro Leu Pro His Gly Arg Glu Ala Glu Gly Ala
 145                 150                 155                 160
 Glu Glu Asp Gly Arg Gly Lys Leu Arg Pro Thr Lys Ala Lys Ser Glu
                 165                 170                 175    
 Arg Lys Lys Lys Ser Phe Gly Leu Leu Pro Pro Gln Leu Pro Pro Pro
             180                 185                 190        
 Pro Ala His Phe Pro Ser Glu Glu Ala Leu Trp Leu Pro Ser Pro Leu
         195                 200                 205            
 Glu Pro Pro Val Leu Gly Pro Gly Pro Ala Ala Met Glu Glu Ser Pro
     210                 215                 220                
 Leu Pro Ala Pro Leu Asn Val Val Pro Pro Glu Val Pro Ser Glu Glu
 225                 230                 235                 240
 Leu Glu Ala Lys Pro Arg Pro Ile Ile Pro Met Leu Tyr Val Val Pro
                 245                 250                 255    
 Arg Pro Gly Lys Ala Ala Phe Asn Gln Glu His Val Ser Cys Gln Gln
             260                 265                 270        
 Ala Phe Glu His Phe Ala Gln Lys Gly Pro Thr Trp Lys Glu Pro Val
         275                 280                 285            
 Ser Pro Met Glu Leu Thr Gly Pro Glu Asp Gly Ala Ala Ser Ser Gly
     290                 295                 300                
 Ala Gly Arg Met Glu Thr Lys Ala Arg Ala Gly Glu Gly Gln Ala Pro
 305                 310                 315                 320
 Ser Thr Phe Ser Lys Leu Lys Met Glu Ile Lys Lys Ser Arg Arg His
                 325                 330                 335    
 Pro Leu Gly Arg Pro Pro Thr Arg Ser Pro Leu Ser Val Val Lys Gln
             340                 345                 350        
 Glu Ala Ser Ser Asp Glu Glu Ala Ser Pro Phe Ser Gly Glu Glu Asp
         355                 360                 365            
 Val Ser Asp Pro Asp Ala Leu Arg Pro Leu Leu Ser Leu Gln Trp Lys
     370                 375                 380                
 Asn Arg Ala Ala Ser Phe Gln Ala Glu Arg Lys Phe Asn Ala Ala Ala
 385                 390                 395                 400
 Ala Arg Thr Glu Pro Tyr Cys Ala Ile Cys Thr Leu Phe Tyr Pro Tyr
                 405                 410                 415    
 Cys Gln Ala Leu Gln Thr Glu Lys Glu Ala Pro Ile Ala Ser Leu Gly
             420                 425                 430        
 Glu Gly Cys Pro Ala Thr Leu Pro Ser Lys Ser Arg Gln Lys Thr Arg
         435                 440                 445            
 Pro Leu Ile Pro Glu Met Cys Phe Thr Ser Gly Gly Glu Asn Thr Glu
     450                 455                 460                
 Pro Leu Pro Ala Asn Ser Tyr Ile Gly Asp Asp Gly Thr Ser Pro Leu
 465                 470                 475                 480
 Ile Ala Cys Gly Lys Cys Cys Leu Gln Val His Ala Ser Cys Tyr Gly
                 485                 490                 495    
 Ile Arg Pro Glu Leu Val Asn Glu Gly Trp Thr Cys Ser Arg Cys Ala
             500                 505                 510        
 Ala His Ala Trp Thr Ala Glu Cys Cys Leu Cys Asn Leu Arg Gly Gly
         515                 520                 525            
 Ala Leu Gln Met Thr Thr Asp Arg Arg Trp Ile His Val Ile Cys Ala
     530                 535                 540                
 Ile Ala Val Pro Glu Ala Arg Phe Leu Asn Val Ile Glu Arg His Pro
 545                 550                 555                 560
 Val Asp Ile Ser Ala Ile Pro Glu Gln Arg Trp Lys Leu Lys Cys Val
                 565                 570                 575    
 Tyr Cys Arg Lys Arg Met Lys Lys Val Ser Gly Ala Cys Ile Gln Cys
             580                 585                 590        
 Ser Tyr Glu His Cys Ser Thr Ser Phe His Val Thr Cys Ala His Ala
         595                 600                 605            
 Ala Gly Val Leu Met Glu Pro Asp Asp Trp Pro Tyr Val Val Ser Ile
     610                 615                 620                
 Thr Cys Leu Lys His Lys Ser Gly Gly His Ala Val Gln Leu Leu Arg
 625                 630                 635                 640
 Ala Val Ser Leu Gly Gln Val Val Ile Thr Lys Asn Arg Asn Gly Leu
                 645                 650                 655    
 Tyr Tyr Arg Cys Arg Val Ile Gly Ala Ala Ser Gln Thr Cys Tyr Glu
             660                 665                 670        
 Val Asn Phe Asp Asp Gly Ser Tyr Ser Asp Asn Leu Tyr Pro Glu Ser
         675                 680                 685            
 Ile Thr Ser Arg Asp Cys Val Gln Leu Gly Pro Pro Ser Glu Gly Glu
     690                 695                 700                
 Leu Val Glu Leu Arg Trp Thr Asp Gly Asn Leu Tyr Lys Ala Lys Phe
 705                 710                 715                 720
 Ile Ser Ser Val Thr Ser His Ile Tyr Gln Val Glu Phe Glu Asp Gly
                 725                 730                 735    
 Ser Gln Leu Thr Val Lys Arg Gly Asp Ile Phe Thr Leu Glu Glu Glu
             740                 745                 750        
 Leu Pro Lys Arg Val Arg Ser Arg Leu Ser Leu Ser Thr Gly Ala Pro
         755                 760                 765            
 Gln Glu Pro Ala Phe Ser Gly Glu Glu Ala Lys Ala Ala Lys Arg Pro
     770                 775                 780                
 Arg Val Gly Thr Pro Leu Ala Thr Glu Asp Ser Gly Arg Ser Gln Asp
 785                 790                 795                 800
 Tyr Val Ala Phe Val Glu Ser Leu Leu Gln Val Gln Gly Arg Pro Gly
                 805                 810                 815    
 Ala Pro Phe
            



      <210> 2980
      <211> 126
      <212> PRT
      <213> Homo sapiens

      <220>
      <221> misc_feature
      <222> (1)...(126)
      <223> Xaa = any amino acid or symbol as shown in the table 8 as set forth in Example 2


      <400> 2980
 Glu Ser Gly Gln Ser Leu Pro Pro Pro Gln Leu Ser Gly Pro Ser Lys
   1               5                  10                  15    
 Gly Ala Gly Ile Pro His Leu Gly Thr Pro Gly Pro Arg Pro Pro Ser
              20                  25                  30        
 Cys Pro Ala Ser Arg Thr Ala Pro Thr Thr Ser Gln Pro Arg Gly Arg
          35                  40                  45            
 Gly Ser Pro Thr Ala Ser Ala Leu Gly Ala Leu Ala Ala Leu Pro Gly
      50                  55                  60                
 Gln Thr His Ala Val Cys Ser Pro Xaa Ile Pro His Leu Gly Thr Pro
  65                  70                  75                  80
 Gly Pro Arg Pro Pro Ser Cys Pro Ala Ser Arg Thr Ala Pro Thr Thr
                  85                  90                  95    
 Ser Gln Pro Arg Gly Arg Gly Ser Pro Thr Ala Ser Ala Leu Gly Ala
             100                 105                 110        
 Leu Ala Ala Leu Pro Gly Gln Thr His Ala Val Cys Ser Pro
         115                 120                 125    



      <210> 2981
      <211> 754
      <212> PRT
      <213> Homo sapiens


      <400> 2981
 Met Gly Asp Phe Asn Thr Pro Leu Ser Thr Leu Asp Arg Ser Thr Arg
   1               5                  10                  15    
 Gln Lys Val Asn Lys Asp Thr Gln Glu Leu Asn Ser Ala Leu His Gln
              20                  25                  30        
 Ala Asp Leu Ile Asp Ile Tyr Arg Thr Leu His Pro Lys Ser Thr Glu
          35                  40                  45            
 Tyr Thr Phe Phe Ser Ala Pro His His Thr Cys Ser Lys Thr Asp His
      50                  55                  60                
 Ile Val Gly Lys Lys Gln Glu Gln Thr His Ser Lys Ala Ser Arg Arg
  65                  70                  75                  80
 Gln Glu Ile Thr Lys Ile Arg Ala Glu Leu Lys Glu Ile Glu Thr Gln
                  85                  90                  95    
 Lys Thr Leu Gln Lys Ile Asn Glu Ser Arg Ser Trp Phe Phe Glu Arg
             100                 105                 110        
 Ile Asn Lys Ile Asp Arg Pro Leu Ala Arg Leu Ile Lys Lys Lys Arg
         115                 120                 125            
 Glu Lys Asn Gln Ile Asp Ala Ile Lys Asn Asp Lys Gly Asp Ile Thr
     130                 135                 140                
 Thr Ser Pro Thr Glu Ile Gln Thr Thr Ile Arg Glu Tyr Tyr Lys His
 145                 150                 155                 160
 Leu Tyr Ala Asn Lys Leu Glu Asp Leu Glu Glu Leu Asp Lys Phe Leu
                 165                 170                 175    
 Glu Thr Tyr Thr Leu Pro Arg Leu Asn Gln Glu Glu Gly Asp Ser Leu
             180                 185                 190        
 Asn Arg Pro Ile Thr Gly Ser Glu Ile Val Ala Ile Ile Asn Ser Leu
         195                 200                 205            
 Pro Thr Lys Lys Ser Pro Gly Pro Asp Gly Phe Thr Ala Glu Phe Tyr
     210                 215                 220                
 Gln Arg Tyr Lys Glu Glu Leu Val Pro Phe Leu Leu Lys Arg Phe Gln
 225                 230                 235                 240
 Ser Ile Glu Lys Glu Gly Ile Leu Pro Asn Ser Phe Tyr Glu Ala Asn
                 245                 250                 255    
 Ile Ile Leu Ile Pro Lys Ser Ala Arg Asp Thr Thr Lys Lys Asp Asn
             260                 265                 270        
 Phe Arg Pro Ile Ser Leu Met Asn Leu Asp Ala Lys Ala Ser Ile Lys
         275                 280                 285            
 Tyr Trp Gln Thr Glu Ser Ser Ser Ile Ser Lys Ser Leu Ser Thr Met
     290                 295                 300                
 Ile Lys Trp Ala Ser Ser Leu Gly Cys Lys Ala Val Leu Glu Val Leu
 305                 310                 315                 320
 Ala Arg Ala Ile Arg Gln Glu Lys Glu Ile Lys Gly Ile Gln Leu Gly
                 325                 330                 335    
 Lys Glu Glu Val Lys Leu Ser Leu Phe Ala Asp Asp Met Ile Val Tyr
             340                 345                 350        
 Leu Glu Asn Pro Ile Val Ser Ala Gln Asn Leu Leu Lys Leu Ile Ser
         355                 360                 365            
 Asn Phe Ser Lys Val Ser Gly Tyr Lys Ile Asn Val Gln Lys Ser Gln
     370                 375                 380                
 Ala Phe Leu Tyr Thr Asn Asn Arg Gln Thr Glu Ser Gln Ile Met Ser
 385                 390                 395                 400
 Glu Leu Pro Phe Thr Ile Ala Ser Lys Arg Ile Lys Tyr Leu Gly Ile
                 405                 410                 415    
 Gln Leu Thr Arg Asp Val Lys Asp Leu Phe Lys Glu Asn Tyr Lys Pro
             420                 425                 430        
 Leu Leu Asn Glu Ile Lys Glu Asp Thr Asn Lys Trp Lys Asn Ile Pro
         435                 440                 445            
 Cys Ser Trp Val Gly Arg Ile Asn Ile Val Lys Met Ala Ile Leu Pro
     450                 455                 460                
 Lys Val Ile Tyr Arg Phe Asn Ala Ile Pro Ile Lys Leu Pro Met Thr
 465                 470                 475                 480
 Phe Phe Thr Glu Leu Glu Lys Thr Thr Leu Lys Phe Ile Trp Asn Gln
                 485                 490                 495    
 Lys Arg Ser Cys Ile Ala Lys Ser Ile Leu Ser Gln Lys Asn Lys Ala
             500                 505                 510        
 Gly Gly Ile Thr Leu Pro Asp Phe Lys Leu Tyr Tyr Lys Ala Thr Val
         515                 520                 525            
 Thr Lys Thr Ala Trp Tyr Trp Tyr Gln Asn Gly Asp Ile Asp Gln Trp
     530                 535                 540                
 Asn Arg Thr Glu Pro Ser Glu Ile Thr Pro His Ile Tyr Asn Tyr Leu
 545                 550                 555                 560
 Ile Phe Asp Lys Pro Glu Lys Asn Lys Gln Trp Gly Lys Asp Ser Leu
                 565                 570                 575    
 Phe Asn Lys Trp Cys Cys Glu Asn Trp Leu Ala Ile Tyr Arg Lys Leu
             580                 585                 590        
 Lys Leu Asp Pro Phe Phe Thr Pro Tyr Thr Lys Ile Asn Ser Arg Trp
         595                 600                 605            
 Thr Lys Asp Leu Asn Val Arg Pro Lys Thr Ile Lys Thr Leu Glu Glu
     610                 615                 620                
 Asn Leu Gly Ile Thr Ile Gln Asp Ile Gly Met Gly Lys Asp Phe Met
 625                 630                 635                 640
 Ser Lys Thr Pro Lys Ala Thr Ala Ala Lys Ala Gln Ile Asp Lys Trp
                 645                 650                 655    
 Asp Leu Ile Lys Leu Lys Ser Phe Cys Thr Ala Lys Glu Thr Thr Ile
             660                 665                 670        
 Arg Val Asn Arg Gln Pro Thr Lys Trp Glu Glu Ile Phe Ala Thr Tyr
         675                 680                 685            
 Ser Ser Asp Lys Gly Leu Ile Ser Arg Ile Tyr Asn Glu Leu Lys Gln
     690                 695                 700                
 Ile Tyr Lys Lys Lys Thr Asn Asn Pro Ile Lys Lys Trp Ala Lys Asp
 705                 710                 715                 720
 Met Asn Arg His Phe Ser Lys Gln Asp Ile Tyr Ala Ala Lys Lys His
                 725                 730                 735    
 Met Lys Lys Cys Ser Ser Ser Leu Ala Ile Arg Glu Cys Lys Ser Lys
             740                 745                 750        
 Pro Gln
        



      <210> 2982
      <211> 45
      <212> PRT
      <213> Homo sapiens


      <400> 2982
 Met Cys Cys Trp Ile Trp Phe Ala Ser Ile Leu Leu Arg Ile Phe Ala
   1               5                  10                  15    
 Leu Met Phe Ile Arg Asp Ile Gly Leu Lys Phe Ser Phe Phe Val Val
              20                  25                  30        
 Ser Leu Pro Gly Phe Gly Ile Arg Met Met Leu Ala Ser
          35                  40                  45



      <210> 2983
      <211> 385
      <212> PRT
      <213> Homo sapiens


      <400> 2983
 Ala Asp Leu Pro Phe Ser Ser Glu Phe Phe Thr Leu Trp Tyr Asn Trp
   1               5                  10                  15    
 Leu Pro Ser Lys Gln Met Pro Cys Lys Lys Asn Glu Glu Asn Glu Asp
              20                  25                  30        
 Ser Val Phe Gln Pro Asn Gln Pro Leu Val Asp Ser Ile Asp Leu Asp
          35                  40                  45            
 Ala Val Ser Ala Leu Leu Ala Arg Thr Ser Ala Glu Leu Leu Ala Val
      50                  55                  60                
 Glu Gln Glu Leu Ala Gln Glu Glu Glu Glu Glu Ser Gly Gln Glu Glu
  65                  70                  75                  80
 Pro Arg Gly Pro Asp Gly Asp Trp Leu Thr Met Leu Arg Glu Ala Ser
                  85                  90                  95    
 Asp Glu Ile Val Ala Glu Lys Glu Ala Glu Val Lys Leu Pro Glu Asp
             100                 105                 110        
 Ser Ser Cys Thr Glu Asp Leu Ser Ser Cys Thr Ser Val Pro Glu Met
         115                 120                 125            
 Asn Glu Asp Gly Asn Arg Lys Glu Ser Asn Cys Ala Lys Asp Leu Arg
     130                 135                 140                
 Ser Gln Pro Pro Thr Arg Ile Pro Thr Leu Val Asp Lys Glu Thr Asn
 145                 150                 155                 160
 Thr Asp Glu Ala Ala Asn Asp Asn Met Ala Val Arg Pro Lys Glu Arg
                 165                 170                 175    
 Ser Ser Leu Ser Ser Arg Gln His Pro Phe Val Arg Ser Ser Val Ile
             180                 185                 190        
 Val Arg Ser Gln Thr Phe Ser Pro Gly Glu Arg Asn Gln Tyr Ile Cys
         195                 200                 205            
 Arg Leu Asn Arg Ser Asp Ser Asp Ser Ser Thr Leu Ala Lys Lys Ser
     210                 215                 220                
 Leu Phe Val Arg Asn Ser Thr Glu Arg Arg Ser Leu Arg Val Lys Arg
 225                 230                 235                 240
 Thr Val Cys Gln Ser Val Leu Arg Arg Thr Thr Gln Glu Cys Pro Val
                 245                 250                 255    
 Arg Thr Ser Leu Asp Leu Glu Leu Asp Leu Gln Ala Ser Leu Thr Arg
             260                 265                 270        
 Gln Ser Arg Leu Asn Asp Glu Leu Gln Ala Leu Arg Asp Leu Arg Gln
         275                 280                 285            
 Lys Leu Glu Glu Leu Lys Ala Gln Gly Glu Thr Asp Leu Pro Pro Gly
     290                 295                 300                
 Val Leu Glu Asp Glu Arg Phe Gln Arg Leu Leu Lys Gln Ala Glu Lys
 305                 310                 315                 320
 Gln Ala Glu Gln Ser Lys Glu Glu Gln Lys Gln Gly Leu Asn Ala Glu
                 325                 330                 335    
 Lys Leu Met Arg Gln Val Ser Lys Asp Val Cys Arg Leu Arg Glu Gln
             340                 345                 350        
 Ser Gln Lys Val Pro Arg Gln Val Gln Ser Phe Arg Glu Lys Ile Ala
         355                 360                 365            
 Tyr Phe Thr Arg Ala Lys Ile Ser Ile Pro Ser Leu Pro Ala Asp Asp
     370                 375                 380                
 Val
 385



      <210> 2984
      <211> 405
      <212> PRT
      <213> Homo sapiens


      <400> 2984
 Thr Leu Gly Gln Cys Gly Gly Ile Pro Leu Cys Ala Ser Asp Gly Arg
   1               5                  10                  15    
 Thr Phe Leu Ser Arg Cys Glu Phe Leu Arg Ala Leu Cys Lys Asp Pro
              20                  25                  30        
 Gln Leu Glu Ile Ala Tyr Arg Gly Asn Cys Lys Asp Val Ser Arg Cys
          35                  40                  45            
 Val Ala Glu Arg Lys Tyr Thr Gln Glu Gln Ala Arg Lys Glu Phe Gln
      50                  55                  60                
 Gln Val Phe Ile Pro Glu Cys Asn Asp Asp Gly Thr Tyr Ser Gln Val
  65                  70                  75                  80
 Gln Cys His Ser Tyr Thr Gly Tyr Cys Trp Cys Val Thr Pro Asn Gly
                  85                  90                  95    
 Arg Pro Ile Ser Gly Thr Ala Val Ala His Lys Thr Pro Arg Cys Pro
             100                 105                 110        
 Gly Ser Val Asn Glu Lys Leu Pro Gln Arg Glu Gly Thr Gly Lys Thr
         115                 120                 125            
 Asp Asp Ala Ala Ala Pro Ala Leu Glu Thr Gln Pro Gln Gly Asp Glu
     130                 135                 140                
 Glu Asp Ile Ala Ser Arg Tyr Pro Thr Leu Trp Thr Glu Gln Val Lys
 145                 150                 155                 160
 Ser Arg Gln Asn Lys Thr Asn Lys Asn Ser Val Ser Ser Cys Asp Gln
                 165                 170                 175    
 Glu His Gln Ser Ala Leu Glu Glu Ala Lys Gln Pro Lys Asn Asp Asn
             180                 185                 190        
 Val Val Ile Pro Glu Cys Ala His Gly Gly Leu Tyr Lys Pro Val Gln
         195                 200                 205            
 Cys His Pro Ser Thr Gly Tyr Cys Trp Cys Val Leu Val Asp Thr Gly
     210                 215                 220                
 Arg Pro Ile Pro Gly Thr Ser Thr Arg Tyr Glu Gln Pro Lys Cys Asp
 225                 230                 235                 240
 Asn Thr Ala Arg Ala His Pro Ala Lys Ala Arg Asp Leu Tyr Lys Gly
                 245                 250                 255    
 Arg Gln Leu Gln Gly Cys Pro Gly Ala Lys Lys His Glu Phe Leu Thr
             260                 265                 270        
 Ser Val Leu Asp Ala Leu Ser Thr Asp Met Val His Ala Ala Ser Asp
         275                 280                 285            
 Pro Ser Ser Phe Val Gln Gly Arg Leu Ser Glu Pro Asp Pro Ser His
     290                 295                 300                
 Thr Leu Glu Glu Arg Val Val His Trp Tyr Phe Lys Leu Leu Asp Lys
 305                 310                 315                 320
 Asn Ser Ser Gly Asp Ile Gly Lys Lys Glu Ile Lys Pro Phe Lys Arg
                 325                 330                 335    
 Phe Leu Arg Lys Lys Ser Lys Pro Lys Lys Cys Val Lys Lys Phe Val
             340                 345                 350        
 Glu Tyr Cys Asp Val Asn Asn Asp Lys Ser Ile Ser Val Gln Glu Leu
         355                 360                 365            
 Met Gly Cys Leu Gly Val Ala Lys Glu Asp Gly Lys Ala Asp Thr Lys
     370                 375                 380                
 Lys Arg His Thr Pro Arg Gly His Ala Glu Ser Thr Ser Asn Arg Gln
 385                 390                 395                 400
 Pro Arg Lys Gln Gly
                 405



      <210> 2985
      <211> 250
      <212> PRT
      <213> Homo sapiens

      <220>
      <221> misc_feature
      <222> (1)...(250)
      <223> Xaa = any amino acid or symbol as shown in the table 8 as set forth in Example 2


      <400> 2985
 Trp Trp Ser Ser Ser Lys Leu Arg Leu Ile Tyr Tyr Tyr Ser Leu Phe
   1               5                  10                  15    
 Phe Phe Phe Phe Phe Phe Phe Phe Phe Gly Met Xaa Ser Tyr Ser Val
              20                  25                  30        
 Thr Gln Ala Arg Val Gln Trp His His Leu Gly Ser Leu Gln Pro Leu
          35                  40                  45            
 Pro Pro Gly Phe Lys Gln Phe Ser Cys Leu Ser Leu Pro Ser Ser Trp
      50                  55                  60                
 Asp Tyr Arg His Pro Pro His Leu Ala Asn Phe Leu Tyr Phe Xaa Xaa
  65                  70                  75                  80
 Arg Trp Gly Phe Thr Met Leu Ala Arg Leu Ile Ser Asn Ser Xaa Pro
                  85                  90                  95    
 Gln Cys Asp Leu Pro Ala Ser Ala Ser Gln Ser Ala Gly Thr Thr Gly
             100                 105                 110        
 Leu Ser His Cys Ala Gln Leu Leu Phe Ala Phe Leu Thr Asp Asn Ser
         115                 120                 125            
 Val Leu Ile Glu Thr Ala Leu Thr Xaa Leu Gln Ser Cys Ala Ser Xaa
     130                 135                 140                
 Lys Leu Asn Xaa Ile Ile Pro Leu Glu Ser Ser Asp Phe Tyr Thr Phe
 145                 150                 155                 160
 Phe Phe Glu Thr Glu Ser His Ser Val Thr Gln Ala Gly Val Gln Cys
                 165                 170                 175    
 Arg Asn Leu Gly Ser Leu Gln Pro Pro Pro Pro Arg Phe Lys Gln Phe
             180                 185                 190        
 Ser Cys Leu Ser Leu Pro Ser Ser Trp Asp Tyr Lys Cys Thr Leu Pro
         195                 200                 205            
 Arg Pro Ala Asn Phe Cys Ile Phe Thr Arg Gln Gly Phe Thr Met Leu
     210                 215                 220                
 Ala Arg Ile Val Ser Pro Gly Ser Leu Gly Leu Met Ile Ser Leu Pro
 225                 230                 235                 240
 Arg Pro Pro Lys Val Leu Gly Leu Gln Val
                 245                 250



      <210> 2986
      <211> 250
      <212> PRT
      <213> Homo sapiens


      <400> 2986
 Thr Thr Tyr Leu Asp Val Gln Arg Cys Leu Glu Tyr Leu Gly Tyr Leu
   1               5                  10                  15    
 Gly Tyr Ser Ile Leu Thr Glu Gln Glu Ser Gln Ala Ser Ala Val Thr
              20                  25                  30        
 Val Thr Arg Asp Lys Lys Ile Asp Leu Gln Lys Lys Gln Thr Gln Arg
          35                  40                  45            
 Asn Val Phe Arg Cys Asn Val Ile Gly Val Lys Asn Cys Gly Lys Ser
      50                  55                  60                
 Gly Val Leu Gln Ala Leu Leu Gly Arg Asn Leu Met Arg Gln Lys Lys
  65                  70                  75                  80
 Ile Arg Glu Asp His Lys Ser Tyr Tyr Ala Ile Asn Thr Val Tyr Val
                  85                  90                  95    
 Tyr Gly Gln Glu Lys Tyr Leu Leu Leu His Asp Ile Ser Glu Ser Glu
             100                 105                 110        
 Phe Leu Thr Glu Ala Glu Ile Ile Cys Asp Val Val Cys Leu Val Tyr
         115                 120                 125            
 Asp Val Ser Asn Pro Lys Ser Phe Glu Tyr Cys Ala Arg Ile Phe Lys
     130                 135                 140                
 Gln His Phe Met Asp Ser Arg Ile Pro Cys Leu Ile Val Ala Ala Lys
 145                 150                 155                 160
 Ser Asp Leu His Glu Val Lys Gln Glu Tyr Ser Ile Ser Pro Thr Asp
                 165                 170                 175    
 Phe Cys Arg Lys His Lys Met Pro Pro Pro Gln Ala Phe Thr Cys Asn
             180                 185                 190        
 Thr Ala Asp Ala Pro Ser Lys Asp Ile Phe Val Lys Leu Thr Thr Met
         195                 200                 205            
 Ala Met Tyr Pro His Val Thr Gln Ala Asp Leu Lys Ser Ser Thr Phe
     210                 215                 220                
 Trp Leu Arg Ala Ser Phe Gly Ala Thr Val Phe Ala Val Leu Gly Phe
 225                 230                 235                 240
 Ala Met Tyr Lys Ala Leu Leu Lys Gln Arg
                 245                 250



      <210> 2987
      <211> 106
      <212> PRT
      <213> Homo sapiens


      <400> 2987
 Met Tyr Thr Arg Glu Leu Leu Ala Trp Ile Gln Gly Leu Tyr Thr Trp
   1               5                  10                  15    
 Glu Leu Leu Ala Trp Ile Gln His Leu Asn Thr Trp Glu Leu Leu Pro
              20                  25                  30        
 Trp Ile Arg Arg Leu Asn Ser Trp Ile Leu Leu Val Cys Pro Lys Leu
          35                  40                  45            
 Leu His Leu Trp Val Phe Gly Lys Thr Met Glu Ile Phe Val Leu Val
      50                  55                  60                
 Lys Asp Met Met Pro Phe Leu Tyr Lys Lys Glu Leu Cys Leu Val Pro
  65                  70                  75                  80
 Glu Val Ile Ser Leu Leu Ile Phe Ser His Leu Asp Thr Ser Lys Glu
                  85                  90                  95    
 Leu Ser Ile Tyr Gly Leu Thr Gln Leu Ile
             100                 105    



      <210> 2988
      <211> 170
      <212> PRT
      <213> Homo sapiens


      <400> 2988
 Met Ala Trp Ala Leu Leu Leu Leu Thr Leu Leu Thr Gln Gly Thr Gly
   1               5                  10                  15    
 Ser Trp Ala Gln Ser Ala Leu Thr Gln Pro Pro Ser Val Ser Gly Ser
              20                  25                  30        
 Pro Gly Gln Ser Val Thr Ile Ser Cys Thr Gly Thr Ser Ser Asp Val
          35                  40                  45            
 Gly Ser Tyr Asn Arg Val Ser Trp Tyr Gln Gln Pro Pro Gly Thr Ala
      50                  55                  60                
 Pro Lys Leu Met Ile Tyr Glu Asn Phe Ser Asn Tyr Ile Leu Met Val
  65                  70                  75                  80
 Ile Ala Thr Thr Leu Ile Leu Asn Asn Ser Ala Ala Asn Ile Pro Thr
                  85                  90                  95    
 Gln Thr Pro Leu Ser Ser Cys Val Asn Met Thr Thr Gly Phe Ile Ser
             100                 105                 110        
 Lys Ser Glu Ile Ala Asp Val Ala Asp Ala Asp Leu Phe Ile Ser Ser
         115                 120                 125            
 Asn Leu Cys Lys Gln Ser Gly Lys Leu Asp Phe Ser Glu His Pro Asp
     130                 135                 140                
 Asp Asn Gly Arg Gly Gly Phe Val Ala Ser Arg Lys Leu Thr Pro Glu
 145                 150                 155                 160
 Pro Ala Val Ser Val Asp Ser Gln Gln Gly
                 165                 170



      <210> 2989
      <211> 309
      <212> PRT
      <213> Homo sapiens


      <400> 2989
 Pro Leu Phe Ser Arg Arg Arg Arg Glu Gly Arg Asp Glu Ser Ser Arg
   1               5                  10                  15    
 Ile Pro Thr Ser Asp Thr Ser Ser Arg Ser His Ile Phe Arg Arg Glu
              20                  25                  30        
 Ser Asn Glu Val Val His Leu Glu Ala Gln Asn Asp Pro Leu Gly Ala
          35                  40                  45            
 Ala Ala Asn Arg Pro Gln Ala Ser Ala Ala Ser Ser Ser Ala Thr Thr
      50                  55                  60                
 Gly Gly Ser Thr Ser Asp Ser Ala Gln Gly Gly Arg Asn Thr Gly Ile
  65                  70                  75                  80
 Ser Gly Ile Leu Pro Gly Ser Leu Phe Arg Phe Ala Val Pro Pro Ala
                  85                  90                  95    
 Leu Gly Ser Asn Leu Thr Asp Asn Val Met Ile Thr Val Asp Ile Ile
             100                 105                 110        
 Pro Ser Gly Trp Asn Ser Ala Asp Gly Lys Ser Asp Lys Thr Lys Ser
         115                 120                 125            
 Ala Pro Ser Arg Asp Pro Glu Arg Leu Gln Lys Ile Lys Glu Ser Leu
     130                 135                 140                
 Leu Leu Glu Asp Ser Glu Glu Glu Glu Gly Asp Leu Cys Arg Ile Cys
 145                 150                 155                 160
 Gln Met Ala Ala Ala Ser Ser Ser Asn Leu Leu Ile Glu Pro Cys Lys
                 165                 170                 175    
 Cys Thr Gly Ser Leu Gln Tyr Val His Gln Asp Cys Met Lys Lys Trp
             180                 185                 190        
 Leu Gln Ala Lys Ile Asn Ser Gly Ser Ser Leu Glu Ala Val Thr Thr
         195                 200                 205            
 Cys Glu Leu Cys Lys Glu Lys Leu Glu Leu Asn Leu Glu Asp Phe Asp
     210                 215                 220                
 Ile His Glu Leu His Arg Ala His Ala Asn Glu Gln Ala Glu Tyr Glu
 225                 230                 235                 240
 Phe Ile Ser Ser Gly Leu Tyr Leu Val Val Leu Leu His Leu Cys Glu
                 245                 250                 255    
 Gln Ser Phe Ser Asp Met Met Gly Asn Thr Asn Glu Pro Ser Thr Arg
             260                 265                 270        
 Val Arg Phe Ile Asn Leu Ala Arg Thr Leu Gln Ala His Met Glu Asp
         275                 280                 285            
 Leu Glu Thr Ser Glu Asp Asp Ser Glu Glu Asp Gly Asp His Asn Arg
     290                 295                 300                
 Thr Phe Asp Ile Ala
 305                



      <210> 2990
      <211> 279
      <212> PRT
      <213> Homo sapiens


      <400> 2990
 Asp Asp Gly Ala Ala His Val Met His Arg Glu Val Trp Met Ala Val
   1               5                  10                  15    
 Phe Ser Tyr Leu Ser His Gln Asp Leu Cys Val Cys Met Arg Val Cys
              20                  25                  30        
 Arg Thr Trp Asn Arg Trp Cys Cys Asp Lys Arg Leu Trp Thr Arg Ile
          35                  40                  45            
 Asp Leu Asn His Cys Lys Ser Ile Thr Pro Leu Met Leu Ser Gly Ile
      50                  55                  60                
 Ile Arg Arg Gln Pro Val Ser Leu Asp Leu Ser Trp Thr Asn Ile Ser
  65                  70                  75                  80
 Lys Lys Gln Leu Ser Trp Leu Ile Asn Arg Leu Pro Gly Leu Arg Asp
                  85                  90                  95    
 Leu Val Leu Ser Gly Cys Ser Trp Ile Ala Val Ser Ala Leu Cys Ser
             100                 105                 110        
 Ser Ser Cys Pro Leu Leu Arg Thr Leu Asp Val Gln Trp Val Glu Gly
         115                 120                 125            
 Leu Lys Asp Ala Gln Met Arg Asp Leu Leu Ser Pro Pro Thr Asp Asn
     130                 135                 140                
 Arg Pro Gly Gln Met Asp Asn Arg Ser Lys Leu Arg Asn Ile Val Glu
 145                 150                 155                 160
 Leu Arg Leu Ala Gly Leu Asp Ile Thr Asp Ala Ser Leu Arg Leu Ile
                 165                 170                 175    
 Ile Arg His Met Pro Leu Leu Ser Lys Leu His Leu Ser Tyr Cys Asn
             180                 185                 190        
 His Val Thr Asp Gln Ser Ile Asn Leu Leu Thr Ala Val Gly Thr Thr
         195                 200                 205            
 Thr Arg Asp Ser Leu Thr Glu Ile Asn Leu Ser Asp Cys Asn Lys Val
     210                 215                 220                
 Thr Asp Gln Cys Leu Ser Phe Phe Lys Arg Cys Gly Asn Ile Cys His
 225                 230                 235                 240
 Ile Asp Leu Arg Tyr Cys Lys Gln Val Thr Lys Glu Gly Cys Glu Gln
                 245                 250                 255    
 Phe Ile Ala Glu Met Ser Val Ser Val Gln Phe Gly Gln Val Glu Glu
             260                 265                 270        
 Lys Leu Leu Gln Lys Leu Ser
         275                



      <210> 2991
      <211> 542
      <212> PRT
      <213> Homo sapiens

      <220>
      <221> misc_feature
      <222> (1)...(542)
      <223> Xaa = any amino acid or symbol as shown in the table 8 as set forth in Example 2


      <400> 2991
 Thr Ile Ser Cys Gly Glu Pro Gly Ser Gly Pro Glu Ala Gly Ala Arg
   1               5                  10                  15    
 Phe Phe Cys Thr Ala Gly Arg Gly Leu Glu Pro Phe Val Met Arg Glu
              20                  25                  30        
 Val Arg Ala Arg Leu Ala Ala Thr Gln Val Glu Tyr Ile Ser Gly Lys
          35                  40                  45            
 Val Phe Phe Thr Thr Cys Ser Asp Leu Asn Met Leu Lys Lys Leu Lys
      50                  55                  60                
 Ser Ala Glu Arg Leu Phe Leu Leu Ile Lys Lys Gln Phe Pro Leu Ile
  65                  70                  75                  80
 Ile Ser Ser Val Ser Lys Gly Lys Ile Phe Asn Glu Met Gln Arg Leu
                  85                  90                  95    
 Ile Asn Glu Asp Pro Gly Ser Trp Leu Asn Ala Ile Ser Ile Trp Lys
             100                 105                 110        
 Asn Leu Leu Glu Leu Asp Ala Lys Lys Glu Lys Leu Ser Gln Arg Asp
         115                 120                 125            
 Asp Asn Gln Leu Lys Arg Lys Val Gly Glu Asn Glu Ile Ile Ala Lys
     130                 135                 140                
 Lys Leu Lys Ile Glu Gln Met Gln Lys Ile Glu Glu Asn Arg Asp Cys
 145                 150                 155                 160
 Gln Leu Glu Lys Gln Ile Lys Glu Glu Thr Leu Glu Gln Arg Asp Phe
                 165                 170                 175    
 Thr Thr Lys Ser Glu Lys Phe Gln Glu Glu Glu Phe Gln Asn Asp Ile
             180                 185                 190        
 Glu Lys Ala Ile Asp Thr His Asn Gln Asn Asp Leu Thr Phe Arg Val
         195                 200                 205            
 Ser Cys Arg Cys Ser Gly Thr Ile Gly Lys Ala Phe Thr Ala Gln Glu
     210                 215                 220                
 Val Gly Lys Val Ile Gly Ile Ala Ile Met Lys His Phe Gly Trp Lys
 225                 230                 235                 240
 Ala Asp Leu Arg Asn Pro Gln Leu Glu Ile Phe Ile His Leu Asn Asp
                 245                 250                 255    
 Ile Tyr Ser Val Val Gly Ile Pro Val Phe Arg Val Ser Leu Ala Ser
             260                 265                 270        
 Arg Ala Tyr Ile Lys Thr Ala Gly Leu Arg Ser Thr Ile Ala Trp Ala
         275                 280                 285            
 Met Ala Ser Leu Ala Asp Ile Lys Val Pro Tyr Gly Ser Asp Xaa Asn
     290                 295                 300                
 Leu Ala Val His Xaa Gly Leu Cys Phe Pro Val Asp Ile Ser Ser Gly
 305                 310                 315                 320
 Gly Cys Leu Phe Ser Pro Ile Ser Ser Thr Thr Gly Pro Asp Ser Gly
                 325                 330                 335    
 Ala Gly Ala Phe Val Leu Asp Pro Met Cys Gly Leu Gly Thr Ile Leu
             340                 345                 350        
 Leu Glu Ala Ala Lys Glu Trp Pro Asp Val Tyr Tyr Val Gly Ala Asp
         355                 360                 365            
 Val Ser Asp Ser Gln Leu Leu Gly Thr Trp Asp Asn Leu Lys Ala Ala
     370                 375                 380                
 Gly Leu Glu Asp Lys Ile Glu Leu Leu Lys Ile Ser Val Ile Glu Leu
 385                 390                 395                 400
 Pro Leu Pro Ser Glu Ser Val Asp Ile Ile Ile Ser Asp Ile Pro Phe
                 405                 410                 415    
 Gly Lys Lys Phe Lys Leu Gly Lys Asp Ile Lys Ser Ile Leu Gln Glu
             420                 425                 430        
 Met Glu Arg Val Leu His Val Gly Gly Thr Ile Val Leu Leu Leu Ser
         435                 440                 445            
 Glu Asp His His Arg Arg Leu Thr Asp Cys Lys Glu Ser Asn Ile Pro
     450                 455                 460                
 Phe Asn Ser Lys Asp Ser His Thr Asp Glu Pro Gly Ile Lys Lys Cys
 465                 470                 475                 480
 Leu Asn Pro Glu Glu Lys Thr Gly Ala Phe Lys Thr Ala Ser Thr Ser
                 485                 490                 495    
 Phe Glu Ala Ser Asn His Lys Phe Leu Asp Arg Met Ser Pro Phe Gly
             500                 505                 510        
 Ser Leu Val Pro Val Glu Cys Tyr Lys Val Ser Leu Gly Lys Thr Asp
         515                 520                 525            
 Ala Phe Ile Cys Lys Tyr Lys Lys Ser His Ser Ser Gly Leu
     530                 535                 540        



      <210> 2992
      <211> 2046
      <212> PRT
      <213> Homo sapiens


      <400> 2992
 Thr Leu Lys Lys Met Leu Glu Ala Ile Asp Lys Asn Arg Ala Leu His
   1               5                  10                  15    
 Ala Ala Glu Arg Leu Gln Thr Lys Leu Arg Glu Arg Gly Asp Val Ala
              20                  25                  30        
 Asn Glu Asp Lys Leu Ser Leu Leu Lys Ser Val Leu Gln Ser Pro Leu
          35                  40                  45            
 Phe Ser Gln Ile Leu Ser Leu Gln Thr Ser Val Gln Gln Leu Lys Asp
      50                  55                  60                
 Gln Val Asn Ile Ala Thr Ser Ala Thr Ser Asn Ile Glu Tyr Ala His
  65                  70                  75                  80
 Val Pro His Leu Ser Pro Ala Val Ile Pro Thr Leu Gln Asn Glu Ser
                  85                  90                  95    
 Phe Leu Leu Ser Pro Asn Asn Gly Asn Leu Glu Ala Leu Thr Gly Pro
             100                 105                 110        
 Gly Ile Pro His Ile Asn Gly Lys Pro Ala Cys Asp Glu Phe Asp Gln
         115                 120                 125            
 Leu Ile Lys Asn Met Ala Gln Gly Arg His Val Glu Val Phe Glu Leu
     130                 135                 140                
 Leu Lys Pro Pro Ser Gly Gly Leu Gly Phe Ser Val Val Gly Leu Arg
 145                 150                 155                 160
 Ser Glu Asn Arg Gly Glu Leu Gly Ile Phe Val Gln Glu Ile Gln Glu
                 165                 170                 175    
 Gly Ser Val Ala His Arg Asp Gly Arg Leu Lys Glu Thr Asp Gln Ile
             180                 185                 190        
 Leu Ala Ile Asn Gly Gln Ala Leu Asp Gln Thr Ile Thr His Gln Gln
         195                 200                 205            
 Ala Ile Ser Ile Leu Gln Lys Ala Lys Asp Thr Val Gln Leu Val Ile
     210                 215                 220                
 Ala Arg Gly Ser Leu Pro Gln Leu Val Ser Pro Ile Val Ser Arg Ser
 225                 230                 235                 240
 Pro Ser Ala Ala Ser Thr Ile Ser Ala His Ser Asn Pro Val His Trp
                 245                 250                 255    
 Gln His Met Glu Thr Ile Glu Leu Val Asn Asp Gly Ser Gly Leu Gly
             260                 265                 270        
 Phe Gly Ile Ile Gly Gly Lys Ala Thr Gly Val Ile Val Lys Thr Ile
         275                 280                 285            
 Leu Pro Gly Gly Val Ala Asp Gln His Gly Arg Leu Cys Ser Gly Asp
     290                 295                 300                
 His Ile Leu Lys Ile Gly Asp Thr Asp Leu Ala Gly Met Ser Ser Glu
 305                 310                 315                 320
 Gln Val Ala Gln Val Leu Arg Gln Cys Gly Asn Arg Val Lys Leu Met
                 325                 330                 335    
 Ile Ala Arg Gly Ala Ile Glu Glu Arg Thr Ala Pro Thr Ala Leu Gly
             340                 345                 350        
 Ile Thr Leu Ser Ser Ser Pro Thr Ser Thr Pro Glu Leu Arg Val Asp
         355                 360                 365            
 Ala Ser Thr Gln Lys Gly Glu Glu Ser Glu Thr Phe Asp Val Glu Leu
     370                 375                 380                
 Thr Lys Asn Val Gln Gly Leu Gly Ile Thr Ile Ala Gly Tyr Ile Gly
 385                 390                 395                 400
 Asp Lys Lys Leu Glu Pro Ser Gly Ile Phe Val Lys Ser Ile Thr Lys
                 405                 410                 415    
 Ser Ser Ala Val Glu His Asp Gly Arg Ile Gln Ile Gly Asp Gln Ile
             420                 425                 430        
 Ile Ala Val Asp Gly Thr Asn Leu Gln Gly Phe Thr Asn Gln Gln Ala
         435                 440                 445            
 Val Glu Val Leu Arg His Thr Gly Gln Thr Val Leu Leu Thr Leu Met
     450                 455                 460                
 Arg Arg Gly Met Lys Gln Glu Ala Glu Leu Met Ser Arg Glu Asp Val
 465                 470                 475                 480
 Thr Lys Asp Ala Asp Leu Ser Pro Val Asn Ala Ser Ile Ile Lys Glu
                 485                 490                 495    
 Asn Tyr Glu Lys Asp Glu Asp Phe Leu Ser Ser Thr Arg Asn Thr Asn
             500                 505                 510        
 Ile Leu Pro Thr Glu Glu Glu Gly Tyr Pro Leu Leu Ser Ala Glu Ile
         515                 520                 525            
 Glu Glu Ile Glu Asp Ala Gln Lys Gln Glu Ala Ala Leu Leu Thr Lys
     530                 535                 540                
 Trp Gln Arg Ile Met Gly Ile Asn Tyr Glu Ile Val Val Ala His Val
 545                 550                 555                 560
 Ser Lys Phe Ser Glu Asn Ser Gly Leu Gly Ile Ser Leu Glu Ala Thr
                 565                 570                 575    
 Val Gly His His Phe Ile Arg Ser Val Leu Pro Glu Gly Pro Val Gly
             580                 585                 590        
 His Ser Gly Lys Leu Phe Ser Gly Asp Glu Leu Leu Glu Val Asn Gly
         595                 600                 605            
 Ile Thr Leu Leu Gly Glu Asn His Gln Asp Val Val Asn Ile Leu Lys
     610                 615                 620                
 Glu Leu Pro Ile Glu Val Thr Met Val Cys Cys Arg Arg Thr Val Pro
 625                 630                 635                 640
 Pro Thr Thr Gln Ser Glu Leu Asp Ser Leu Asp Leu Cys Asp Ile Glu
                 645                 650                 655    
 Leu Thr Glu Lys Pro His Val Asp Leu Gly Glu Phe Ile Gly Ser Ser
             660                 665                 670        
 Glu Thr Glu Asp Pro Val Leu Ala Met Thr Asp Ala Gly Gln Ser Thr
         675                 680                 685            
 Glu Glu Val Gln Ala Pro Leu Ala Met Trp Glu Ala Gly Ile Gln His
     690                 695                 700                
 Ile Glu Leu Glu Lys Gly Ser Lys Gly Leu Gly Phe Ser Ile Leu Asp
 705                 710                 715                 720
 Tyr Gln Asp Pro Ile Asp Pro Ala Ser Thr Val Ile Ile Ile Arg Ser
                 725                 730                 735    
 Leu Val Pro Gly Gly Ile Ala Glu Lys Asp Gly Arg Leu Leu Pro Gly
             740                 745                 750        
 Asp Arg Leu Met Phe Val Asn Asp Val Asn Leu Glu Asn Ser Ser Leu
         755                 760                 765            
 Glu Glu Ala Val Glu Ala Leu Lys Gly Ala Pro Ser Gly Thr Val Arg
     770                 775                 780                
 Ile Gly Val Ala Lys Pro Leu Pro Leu Ser Pro Glu Glu Gly Tyr Val
 785                 790                 795                 800
 Ser Ala Lys Glu Asp Ser Phe Leu Tyr Pro Pro His Ser Cys Glu Glu
                 805                 810                 815    
 Ala Gly Leu Ala Asp Lys Pro Leu Phe Arg Ala Asp Leu Ala Leu Val
             820                 825                 830        
 Gly Thr Asn Asp Ala Asp Leu Val Asp Glu Ser Thr Phe Glu Ser Pro
         835                 840                 845            
 Tyr Ser Pro Glu Asn Asp Ser Ile Tyr Ser Thr Gln Ala Ser Ile Leu
     850                 855                 860                
 Ser Leu His Gly Ser Ser Cys Gly Asp Gly Leu Asn Tyr Gly Ser Ser
 865                 870                 875                 880
 Leu Pro Ser Ser Pro Pro Lys Asp Val Ile Glu Asn Ser Cys Asp Pro
                 885                 890                 895    
 Val Leu Asp Leu His Met Ser Leu Glu Glu Leu Tyr Thr Gln Asn Leu
             900                 905                 910        
 Leu Gln Arg Gln Asp Glu Asn Thr Pro Ser Val Asp Ile Ser Met Gly
         915                 920                 925            
 Pro Ala Ser Gly Phe Thr Ile Asn Asp Tyr Thr Pro Ala Asn Ala Ile
     930                 935                 940                
 Glu Gln Gln Tyr Glu Cys Glu Asn Thr Ile Val Trp Thr Glu Ser His
 945                 950                 955                 960
 Leu Pro Ser Glu Val Ile Ser Ser Ala Glu Leu Pro Ser Val Leu Pro
                 965                 970                 975    
 Asp Ser Ala Gly Lys Gly Ser Glu Tyr Leu Leu Glu Gln Ser Ser Leu
             980                 985                 990        
 Ala Cys Asn Ala Glu Cys Val Met Leu Gln Asn Val Ser Lys Glu Ser
         995                1000                1005            
 Phe Glu Arg Thr Ile Asn Ile Ala Lys Gly Asn Ser Ser Leu Gly Met
    1010                1015                1020                
 Thr Val Ser Ala Asn Lys Asp Gly Leu Gly Met Ile Val Arg Ser Ile
1025                1030                1035                1040
 Ile His Gly Gly Ala Ile Ser Arg Asp Gly Arg Ile Ala Ile Gly Asp
                1045                1050                1055    
 Cys Ile Leu Ser Ile Asn Glu Glu Ser Thr Ile Ser Val Thr Asn Ala
            1060                1065                1070        
 Gln Ala Arg Ala Met Leu Arg Arg His Ser Leu Ile Gly Pro Asp Ile
        1075                1080                1085            
 Lys Ile Thr Tyr Val Pro Ala Glu His Leu Glu Glu Phe Lys Ile Ser
    1090                1095                1100                
 Leu Gly Gln Gln Ser Gly Arg Val Met Ala Leu Asp Ile Phe Ser Ser
1105                1110                1115                1120
 Tyr Thr Gly Arg Asp Ile Pro Glu Leu Pro Glu Arg Glu Glu Gly Glu
                1125                1130                1135    
 Gly Glu Glu Ser Glu Leu Gln Asn Thr Ala Tyr Ser Asn Trp Asn Gln
            1140                1145                1150        
 Pro Arg Arg Val Glu Leu Trp Arg Glu Pro Ser Lys Ser Leu Gly Ile
        1155                1160                1165            
 Ser Ile Val Gly Gly Arg Gly Met Gly Ser Arg Leu Ser Asn Gly Glu
    1170                1175                1180                
 Val Met Arg Gly Ile Phe Ile Lys His Val Leu Glu Asp Ser Pro Ala
1185                1190                1195                1200
 Gly Lys Asn Gly Thr Leu Lys Pro Gly Asp Arg Ile Val Glu Val Asp
                1205                1210                1215    
 Gly Met Asp Leu Arg Asp Ala Ser His Glu Gln Ala Val Glu Ala Ile
            1220                1225                1230        
 Arg Lys Ala Gly Asn Pro Val Val Phe Met Val Gln Ser Ile Ile Asn
        1235                1240                1245            
 Arg Pro Arg Lys Ser Pro Leu Pro Ser Leu Leu His Asn Leu Tyr Pro
    1250                1255                1260                
 Lys Tyr Asn Phe Ser Ser Thr Asn Pro Phe Ala Asp Ser Leu Gln Ile
1265                1270                1275                1280
 Asn Ala Asp Lys Ala Pro Ser Gln Ser Glu Ser Glu Pro Glu Lys Ala
                1285                1290                1295    
 Pro Leu Cys Ser Val Pro Pro Pro Pro Pro Ser Ala Phe Ala Glu Met
            1300                1305                1310        
 Gly Ser Asp His Thr Gln Ser Ser Ala Ser Lys Ile Ser Gln Asp Val
        1315                1320                1325            
 Asp Lys Glu Asp Glu Phe Gly Tyr Ser Trp Lys Asn Ile Arg Glu Arg
    1330                1335                1340                
 Tyr Gly Thr Leu Thr Gly Glu Leu His Met Ile Glu Leu Glu Lys Gly
1345                1350                1355                1360
 His Ser Gly Leu Gly Leu Ser Leu Ala Gly Asn Lys Asp Arg Ser Arg
                1365                1370                1375    
 Met Ser Val Phe Ile Val Gly Ile Asp Pro Asn Gly Ala Ala Gly Lys
            1380                1385                1390        
 Asp Gly Arg Leu Gln Ile Ala Asp Glu Leu Leu Glu Ile Asn Gly Gln
        1395                1400                1405            
 Ile Leu Tyr Gly Arg Ser His Gln Asn Ala Ser Ser Ile Ile Lys Cys
    1410                1415                1420                
 Ala Pro Ser Lys Val Lys Ile Ile Phe Ile Arg Asn Lys Asp Ala Val
1425                1430                1435                1440
 Asn Gln Met Ala Val Cys Pro Gly Asn Ala Val Glu Pro Leu Pro Ser
                1445                1450                1455    
 Asn Ser Glu Asn Leu Gln Asn Lys Glu Thr Glu Pro Thr Val Thr Thr
            1460                1465                1470        
 Ser Asp Ala Ala Val Asp Leu Ser Ser Phe Lys Asn Val Gln His Leu
        1475                1480                1485            
 Glu Leu Pro Lys Asp Gln Gly Gly Leu Gly Ile Ala Ile Ser Glu Glu
    1490                1495                1500                
 Asp Thr Leu Ser Gly Val Ile Ile Lys Ser Leu Thr Glu His Gly Val
1505                1510                1515                1520
 Ala Ala Thr Asp Gly Arg Leu Lys Val Gly Asp Gln Ile Leu Ala Val
                1525                1530                1535    
 Asp Asp Glu Ile Val Val Gly Tyr Pro Ile Glu Lys Phe Ile Ser Leu
            1540                1545                1550        
 Leu Lys Thr Ala Lys Met Thr Val Lys Leu Thr Ile His Ala Glu Asn
        1555                1560                1565            
 Pro Asp Ser Gln Ala Val Pro Ser Ala Ala Gly Ala Ala Ser Gly Glu
    1570                1575                1580                
 Lys Lys Asn Ser Ser Gln Ser Leu Met Val Pro Gln Ser Gly Ser Pro
1585                1590                1595                1600
 Glu Pro Glu Ser Ile Arg Asn Thr Ser Arg Ser Ser Thr Pro Ala Ile
                1605                1610                1615    
 Phe Ala Ser Asp Pro Ala Thr Cys Pro Ile Ile Pro Gly Cys Glu Thr
            1620                1625                1630        
 Thr Ile Glu Ile Ser Lys Gly Arg Thr Gly Leu Gly Leu Ser Ile Val
        1635                1640                1645            
 Gly Gly Ser Asp Thr Leu Leu Gly Ala Ile Ile Ile His Glu Val Tyr
    1650                1655                1660                
 Glu Glu Gly Ala Ala Cys Lys Asp Gly Arg Leu Trp Ala Gly Asp Gln
1665                1670                1675                1680
 Ile Leu Glu Val Asn Gly Ile Asp Leu Arg Lys Ala Thr His Asp Glu
                1685                1690                1695    
 Ala Ile Asn Val Leu Arg Gln Thr Pro Gln Arg Val Arg Leu Thr Leu
            1700                1705                1710        
 Tyr Arg Asp Glu Ala Pro Tyr Lys Glu Glu Glu Val Cys Asp Thr Leu
        1715                1720                1725            
 Thr Ile Glu Leu Gln Lys Lys Pro Gly Lys Gly Leu Gly Leu Ser Ile
    1730                1735                1740                
 Val Gly Lys Arg Asn Asp Thr Gly Val Phe Val Ser Asp Ile Val Lys
1745                1750                1755                1760
 Gly Gly Ile Ala Asp Ala Asp Gly Arg Leu Met Gln Gly Asp Gln Ile
                1765                1770                1775    
 Leu Met Val Asn Gly Glu Asp Val Arg Asn Ala Thr Gln Glu Ala Val
            1780                1785                1790        
 Ala Ala Leu Leu Lys Cys Ser Leu Gly Thr Val Thr Leu Glu Val Gly
        1795                1800                1805            
 Arg Ile Lys Ala Gly Ser Ser Thr Ser Glu Ser Leu Glu Ser Ser Ser
    1810                1815                1820                
 Lys Lys Asn Ala Leu Ala Ser Glu Ile Gln Gly Leu Arg Thr Val Glu
1825                1830                1835                1840
 Met Lys Lys Gly Pro Thr Asp Ser Leu Gly Ile Ser Ile Ala Gly Gly
                1845                1850                1855    
 Val Gly Ser Pro Leu Gly Asp Val Pro Ile Phe Ile Ala Met Met His
            1860                1865                1870        
 Pro Thr Gly Val Ala Ala Gln Thr Gln Lys Leu Arg Val Gly Asp Arg
        1875                1880                1885            
 Ile Val Thr Ile Cys Gly Thr Ser Thr Glu Gly Met Thr His Thr Gln
    1890                1895                1900                
 Ala Val Asn Leu Leu Lys Asn Ala Ser Gly Ser Ile Glu Met Gln Val
1905                1910                1915                1920
 Val Ala Gly Gly Asp Val Ser Val Val Thr Gly His Gln Gln Glu Pro
                1925                1930                1935    
 Ala Ser Ser Ser Leu Ser Phe Thr Gly Leu Thr Ser Ser Ser Ile Phe
            1940                1945                1950        
 Gln Asp Asp Leu Gly Pro Pro Gln Cys Lys Ser Ile Thr Leu Glu Arg
        1955                1960                1965            
 Gly Pro Asp Gly Leu Gly Phe Ser Ile Val Gly Gly Tyr Gly Ser Pro
    1970                1975                1980                
 His Gly Asp Leu Pro Ile Tyr Val Lys Thr Val Phe Ala Lys Gly Ala
1985                1990                1995                2000
 Ala Ser Glu Asp Gly Arg Leu Lys Arg Gly Asp Gln Ile Ile Ala Val
                2005                2010                2015    
 Asn Gly Gln Ser Leu Glu Gly Val Thr His Glu Glu Ala Val Ala Ile
            2020                2025                2030        
 Leu Lys Arg Thr Lys Gly Thr Val Thr Leu Met Val Leu Ser
        2035                2040                2045    



      <210> 2993
      <211> 76
      <212> PRT
      <213> Homo sapiens


      <400> 2993
 Met Glu Arg Pro Leu Cys Ser His Leu Cys Ser Cys Leu Ala Met Leu
   1               5                  10                  15    
 Ala Leu Leu Ser Pro Leu Ser Leu Ala Gln Tyr Asp Ser Trp Pro His
              20                  25                  30        
 Tyr Pro Glu Tyr Phe Gln Gln Pro Ala Pro Glu Tyr His Gln Pro Gln
          35                  40                  45            
 Ala Pro Ala Asn Val Ala Lys Ile Gln Leu Arg Leu Ala Gly Gln Lys
      50                  55                  60                
 Arg Lys His Ser Glu Gly Pro Gly Gly Gly Val Leu
  65                  70                  75    



      <210> 2994
      <211> 50
      <212> PRT
      <213> Homo sapiens


      <400> 2994
 Val Asp Pro Arg Val Arg Cys Gly Lys Glu Thr Met Val Thr Ser Thr
   1               5                  10                  15    
 Thr Glu Ser Ser Arg Cys Glu Tyr Leu Met Glu Leu Met Thr Pro Ala
              20                  25                  30        
 Ala Cys Pro Glu Pro Pro Pro Glu Ala Pro Thr Glu Asp Asp His Asp
          35                  40                  45            
 Glu Leu
      50



      <210> 2995
      <211> 47
      <212> PRT
      <213> Homo sapiens


      <400> 2995
 Met Met Gly Arg Ile Phe Ala Ala Leu Ser Leu Ile Lys Leu Met Met
   1               5                  10                  15    
 Tyr Ser Leu Phe Pro Val Ile Glu Ser Ser Leu Cys His Leu Glu Val
              20                  25                  30        
 Trp Ala Trp Arg His Ile Trp Pro Thr Ala Gly Arg Gly Val Pro
          35                  40                  45        



      <210> 2996
      <211> 100
      <212> PRT
      <213> Homo sapiens


      <400> 2996
 Asp Phe Arg Thr Asp Phe Asp Lys Pro Asp Phe Lys Arg Ser Ile Val
   1               5                  10                  15    
 Cys Leu Glu Asp Leu Gln Ile Gly Thr Val Leu Thr Gly Lys Val Glu
              20                  25                  30        
 Asn Ala Thr Leu Phe Gly Ile Phe Val Asp Ile Gly Val Gly Lys Ser
          35                  40                  45            
 Gly Leu Ile Pro Ile Arg Asn Val Thr Glu Ala Lys Leu Ser Lys Thr
      50                  55                  60                
 Lys Lys Arg Arg Ser Leu Gly Leu Gly Pro Gly Glu Arg Val Glu Val
  65                  70                  75                  80
 Gln Val Leu Asn Ile Asp Ile Pro Arg Ser Arg Ile Thr Leu Asp Leu
                  85                  90                  95    
 Ile Arg Val Leu
             100



      <210> 2997
      <211> 245
      <212> PRT
      <213> Homo sapiens


      <400> 2997
 Arg Ser Gly Pro Pro Phe Ser Val Ser Leu Leu Ile Asp Ser Arg Ser
   1               5                  10                  15    
 Gly Pro Pro Phe Ser Val Ser Leu Leu Ile Asp Asn Arg Ser Gly Pro
              20                  25                  30        
 Pro Phe Ser Val Ser Leu Leu Ile Asp Ser Arg Ser Gly Pro Pro Phe
          35                  40                  45            
 Ser Val Ser Leu Leu Ile Asp Ser Arg Ser Gly Pro Pro Phe Ser Val
      50                  55                  60                
 Ser Leu Leu Ile Asp Ser Arg Ser Gly Pro Pro Phe Ser Val Ser Leu
  65                  70                  75                  80
 Leu Ile Asp Asn Arg Ser Gly Pro Pro Phe Ser Val Ser Leu Leu Ile
                  85                  90                  95    
 Asp Asn Arg Ser Gly Pro Pro Phe Ser Val Ser Leu Leu Ile Asp Ser
             100                 105                 110        
 Arg Ser Gly Pro Pro Phe Ser Val Ser Leu Leu Ile Asp Asn Arg Ser
         115                 120                 125            
 Gly Pro Pro Phe Ser Val Ser Leu Leu Ile Asp Ser Arg Ser Gly Pro
     130                 135                 140                
 Pro Phe Ser Val Ser Leu Leu Ile Asp Ser Arg Ser Gly Pro Pro Phe
 145                 150                 155                 160
 Ser Val Ser Leu Leu Ile Asp Ser Arg Ser Gly Pro Pro Phe Ser Val
                 165                 170                 175    
 Ser Leu Leu Ile Asp Asn Arg Ser Gly Pro Pro Phe Ser Val Ser Leu
             180                 185                 190        
 Leu Ile Asp Asn Arg Ser Gly Pro Pro Phe Ser Val Ser Leu Leu Ile
         195                 200                 205            
 Asp Ser Arg Ser Gly Pro Pro Cys Arg Ile Ser Phe Lys Thr Thr Thr
     210                 215                 220                
 Ala His Gly Gly Tyr Phe Pro Val Ser Gln Arg Cys Arg Pro Arg His
 225                 230                 235                 240
 Gly Asn Cys Thr Ala
                 245



      <210> 2998
      <211> 353
      <212> PRT
      <213> Homo sapiens


      <400> 2998
 Ile Ser Ser Gly Gly Pro Arg Glu Leu Gly Leu Lys Met Ile Ile Val
   1               5                  10                  15    
 Pro Gly Ser Gln Leu Ser Gln Leu Pro Pro Gly Leu Asp Ser Thr Glu
              20                  25                  30        
 Phe Ala Ala Ile Val Gly Asn Leu Leu Asp Asn Ala Phe Glu Ala Ser
          35                  40                  45            
 Leu Arg Ser Asp Glu Gly Asn Lys Ile Val Glu Leu Phe Leu Ser Asp
      50                  55                  60                
 Glu Gly Asp Asp Val Val Ile Glu Val Ala Asp Gln Gly Cys Gly Val
  65                  70                  75                  80
 Pro Glu Ser Leu Arg Asp Lys Ile Phe Glu Gln Gly Val Ser Thr Arg
                  85                  90                  95    
 Ala Asp Glu Pro Gly Glu His Gly Ile Gly Leu Tyr Leu Ile Ala Ser
             100                 105                 110        
 Tyr Val Thr Arg Cys Gly Gly Gly Ile Thr Leu Glu Asp Asn Asp Pro
         115                 120                 125            
 Cys Ala Pro Leu Thr Leu Leu Ile Val Glu Asp Glu Thr Pro Leu Ala
     130                 135                 140                
 Glu Met His Ala Glu Tyr Ile Arg His Ile Pro Gly Phe Ser Gln Ile
 145                 150                 155                 160
 Leu Leu Ala Gly Asn Leu Ala Gln Ala Arg Met Met Ile Glu Arg Phe
                 165                 170                 175    
 Lys Pro Gly Leu Ile Leu Leu Asp Asn Tyr Leu Pro Asp Gly Arg Gly
             180                 185                 190        
 Ile Asn Leu Leu His Glu Leu Val Gln Ala His Tyr Pro Gly Asp Val
         195                 200                 205            
 Val Phe Thr Thr Ala Ala Ser Asp Met Glu Thr Val Ser Glu Ala Val
     210                 215                 220                
 Arg Cys Gly Val Phe Asp Tyr Leu Ile Lys Pro Ile Ala Tyr Glu Arg
 225                 230                 235                 240
 Leu Gly Gln Thr Leu Thr Gly Phe Pro Gln Arg Lys His Met Leu Lys
                 245                 250                 255    
 Ser Ile Glu Ser Ala Thr Gln Lys Gln Ile Asp Glu Met Phe Asn Ala
             260                 265                 270        
 Tyr Ala Arg Gly Glu Pro Lys Asp Glu Leu Pro Thr Gly Ile Asp Pro
         275                 280                 285            
 Leu Thr Leu Asn Ala Val Arg Lys Leu Phe Lys Glu Pro Gly Val Gln
     290                 295                 300                
 His Thr Ala Glu Thr Val Ala Gln Ala Leu Thr Ile Ser Arg Thr Thr
 305                 310                 315                 320
 Ala Arg Arg Tyr Leu Glu Tyr Cys Ala Ser Arg His Leu Ile Ile Ala
                 325                 330                 335    
 Glu Ile Val His Gly Lys Val Gly Arg Pro Gln Arg Ile Tyr His Ser
             340                 345                 350        
 Gly
    



      <210> 2999
      <211> 143
      <212> PRT
      <213> Homo sapiens


      <400> 2999
 Met Asp His Cys Gly Ala Leu Phe Leu Cys Leu Cys Leu Leu Thr Leu
   1               5                  10                  15    
 Gln Asn Ala Thr Thr Glu Thr Trp Glu Glu Leu Leu Ser Tyr Met Glu
              20                  25                  30        
 Asn Met Gln Val Ser Arg Gly Arg Ser Ser Val Phe Ser Ser Arg Gln
          35                  40                  45            
 Leu His Gln Leu Glu Gln Met Leu Leu Asn Thr Ser Phe Pro Gly Tyr
      50                  55                  60                
 Asn Leu Thr Leu Gln Thr Pro Thr Ile Gln Ser Leu Ala Phe Lys Leu
  65                  70                  75                  80
 Ser Cys Asp Phe Ser Gly Leu Ser Leu Thr Ser Ala Thr Leu Lys Arg
                  85                  90                  95    
 Val Pro Gln Ala Gly Gly Gln His Ala Arg Gly Gln His Ala Met Gln
             100                 105                 110        
 Phe Pro Ala Glu Leu Thr Arg Asp Ala Cys Lys Thr Arg Pro Arg Glu
         115                 120                 125            
 Leu Arg Leu Ile Cys Ile Tyr Phe Ser Asn Thr His Phe Phe Lys
     130                 135                 140            



      <210> 3000
      <211> 121
      <212> PRT
      <213> Homo sapiens


      <400> 3000
 Thr Met Arg Arg Leu Leu His Arg Arg Lys Asp Phe Thr Leu Arg Thr
   1               5                  10                  15    
 Asp Leu Leu Gln Arg Ala Ile Tyr Leu Ile Gln Cys Trp Thr Ile Gly
              20                  25                  30        
 Ser Trp His Cys Asn His Arg Gly Ser Ser Pro Ile Leu Ser His Ile
          35                  40                  45            
 Leu Leu Thr Arg Pro Arg Trp Leu Ile Val Ala Lys Lys His Ala Ser
      50                  55                  60                
 Ser Ile Ile Ser Leu Lys Ile Ser His Tyr Leu Pro Arg Thr His Lys
  65                  70                  75                  80
 Arg Lys Val Gly Ser Ile Cys Tyr Leu Asn Thr Ala Leu Thr Pro Phe
                  85                  90                  95    
 Arg Arg Trp Arg Ile Ile Arg Tyr Ser Leu Pro Thr Thr Ala Ser Met
             100                 105                 110        
 Leu Leu Ala Arg Arg Tyr Arg Cys Cys
         115                 120    



      <210> 3001
      <211> 301
      <212> PRT
      <213> Homo sapiens

      <220>
      <221> misc_feature
      <222> (1)...(301)
      <223> Xaa = any amino acid or symbol as shown in the table 8 as set forth in Example 2


      <400> 3001
 Met Arg Ala Gly Phe Thr Ser Asn Val Leu Thr Phe Leu Thr Cys Thr
   1               5                  10                  15    
 Ser His Phe Leu Asn Thr Phe Arg Ala Ala Asp Val Ala Asn Val Gln
              20                  25                  30        
 Thr Ala Thr Ser Asn Phe Arg Gln Ile Gln Val Phe Glu Asp Ile Ile
          35                  40                  45            
 Thr Gln Tyr Asn Gly Lys Tyr Ile Leu Ala Val Glu Gly Asn Pro Pro
      50                  55                  60                
 Leu Gly Glu Gln Gly Met Phe Cys Ile Ser Ser Gly Arg Pro Phe Ile
  65                  70                  75                  80
 Glu Lys Leu Lys Arg Ala Ala Ala Gly Ala Ser Ala Ile Ile Ala Trp
                  85                  90                  95    
 Gly Thr Cys Ala Ser Trp Gly Cys Val Gln Ala Ala Arg Pro Asn Pro
             100                 105                 110        
 Thr Gln Ala Thr Pro Ile Asp Lys Val Ile Thr Asp Lys Pro Ile Ile
         115                 120                 125            
 Lys Val Pro Gly Cys Pro Pro Ile Pro Asp Val Met Ser Ala Ile Ile
     130                 135                 140                
 Thr Tyr Met Val Thr Phe Asp Arg Leu Pro Asp Val Asp Arg Met Gly
 145                 150                 155                 160
 Arg Pro Leu Met Phe Tyr Gly Gln Arg Ile His Asp Lys Cys Tyr Arg
                 165                 170                 175    
 Arg Ala His Phe Asp Ala Gly Glu Phe Val Gln Ser Trp Asp Asp Asp
             180                 185                 190        
 Ala Ala Pro Lys Val Thr Ala Cys Thr Lys Trp Ala Ala Lys Gly Leu
         195                 200                 205            
 Pro Pro Ile Thr Pro Val Pro His Thr Leu Glu Xaa Trp Val Trp Ser
     210                 215                 220                
 Arg Leu Leu Ala Gly Gly Asn Gly Leu Asp Arg Gly Arg Phe Ser Gly
 225                 230                 235                 240
 Val Asp Ser Ser Trp Ile Ser Tyr Leu Ser Ser Ala Ile Ser Val Thr
                 245                 250                 255    
 Met Ala Pro Ala Thr Thr Leu Asn Gln Thr Ser Lys Ala Ala Leu Ala
             260                 265                 270        
 Ala Cys Ala Ile Ser Thr Leu Cys Asn Gly Trp Pro Ala Val Ile Leu
         275                 280                 285            
 Ala Gln His Arg Trp Met Lys Trp Ser Gly Leu Ala Ser
     290                 295                 300    



      <210> 3002
      <211> 149
      <212> PRT
      <213> Homo sapiens


      <400> 3002
 Ala His Arg Arg Ala Thr Met Thr Ile His Lys Lys Gly Gln Ala His
   1               5                  10                  15    
 Trp Glu Gly Asp Ile Lys Arg Gly Lys Gly Thr Val Ser Thr Glu Ser
              20                  25                  30        
 Gly Val Leu Asn Gln Gln Pro Tyr Gly Phe Asn Thr Arg Phe Glu Gly
          35                  40                  45            
 Glu Lys Gly Thr Asn Pro Glu Glu Leu Ile Gly Ala Ala His Ala Ala
      50                  55                  60                
 Cys Phe Ser Met Ala Leu Ser Leu Met Leu Gly Glu Ala Gly Phe Thr
  65                  70                  75                  80
 Pro Thr Ser Ile Asp Thr Thr Ala Asp Val Ser Leu Asp Lys Val Asp
                  85                  90                  95    
 Ala Gly Phe Ala Ile Thr Lys Ile Ala Leu Lys Ser Glu Val Ala Val
             100                 105                 110        
 Pro Gly Ile Asp Ala Ser Thr Phe Asp Gly Ile Ile Gln Lys Ala Lys
         115                 120                 125            
 Ala Gly Cys Pro Val Ser Gln Val Leu Lys Ala Glu Ile Thr Leu Asp
     130                 135                 140                
 Tyr Gln Leu Lys Ser
 145                



      <210> 3003
      <211> 37
      <212> PRT
      <213> Homo sapiens


      <400> 3003
 Phe Thr Pro Thr Phe Leu His Ser Asp Lys Ile Ser Ala Ala Gly Thr
   1               5                  10                  15    
 Phe Ser Ala Thr Thr Thr Ala Met Ser Arg Arg Phe Ala Gly Lys Arg
              20                  25                  30        
 Glu Ile Ser Arg Ala
          35        



      <210> 3004
      <211> 190
      <212> PRT
      <213> Homo sapiens

      <220>
      <221> misc_feature
      <222> (1)...(190)
      <223> Xaa = any amino acid or symbol as shown in the table 8 as set forth in Example 2


      <400> 3004
 Met Arg Trp Arg Ser Lys Ser Ala Trp Arg Ala Glu Pro Lys Ser Arg
   1               5                  10                  15    
 Thr Asn Ser Gly Thr Ala Ser Asn Val Ser Pro Ser Arg Pro Leu Glu
              20                  25                  30        
 Cys Xaa Arg Phe Leu Arg Leu Val Ser Gly Glu Leu Ile Leu Ala Leu
          35                  40                  45            
 Ile Ala Phe Ile Cys Ile Glu Thr Ile Met Ala Cys Ser Pro Cys Glu
      50                  55                  60                
 Gly Leu Tyr Phe Phe Glu Phe Val Ser Cys Ser Ala Phe Val Val Thr
  65                  70                  75                  80
 Gly Val Leu Leu Ile Met Phe Ser Leu Asn Leu His Met Arg Ile Pro
                  85                  90                  95    
 Gln Ile Asn Trp Asn Leu Thr Asp Leu Val Asn Thr Gly Leu Ser Ala
             100                 105                 110        
 Phe Leu Phe Phe Ile Ala Ser Ile Val Leu Ala Ala Leu Asn His Arg
         115                 120                 125            
 Ala Gly Ala Glu Ile Ala Ala Val Ile Phe Gly Phe Leu Ala Thr Ala
     130                 135                 140                
 Ala Tyr Ala Val Asn Thr Phe Leu Ala Val Gln Lys Trp Arg Val Ser
 145                 150                 155                 160
 Val Arg Gln Gln Ser Thr Asn Asp Tyr Ile Arg Ala Arg Thr Glu Ser
                 165                 170                 175    
 Arg Asp Val Asp Ser Arg Pro Glu Ile Gln Arg Leu Asp Thr
             180                 185                 190



      <210> 3005
      <211> 136
      <212> PRT
      <213> Homo sapiens


      <400> 3005
 Met Leu Leu His Val Gly Thr Thr Ala His Val Ala Val Glu His Leu
   1               5                  10                  15    
 Ile Gly Gly Val Gln Asp Asp Glu Asp Leu Glu Met Thr Ile Gly Cys
              20                  25                  30        
 His Gly Glu Glu Met Ile Gly Asp Leu Asp Lys Asn Ser Phe Gly Ala
          35                  40                  45            
 Gly Gly Leu Cys Ile Gly Glu Arg Val Gly Gly Pro Gly Cys Cys Glu
      50                  55                  60                
 Val Leu Ile Arg Met Thr Pro Thr Glu Asp Val Gly Glu Glu Arg Ser
  65                  70                  75                  80
 Asp Met Lys Gly Ile Gln Leu Ser Met Gln Glu Arg Thr Arg Cys Arg
                  85                  90                  95    
 Gln Phe Pro Glu Gly Arg Arg His Gln Leu Gly His Leu Leu Gln Gly
             100                 105                 110        
 Gly Leu Gly Arg Gly Glu Ala Trp Lys Tyr His Gln Ile Trp Glu Glu
         115                 120                 125            
 Gly His Trp Leu Leu Arg Glu Gln
     130                 135    



      <210> 3006
      <211> 103
      <212> PRT
      <213> Homo sapiens


      <400> 3006
 Met Glu Gly Ser Arg Met Lys Tyr Arg Ile Ala Leu Ala Val Ser Leu
   1               5                  10                  15    
 Phe Ala Leu Ser Ala Gly Ser Tyr Ala Thr Thr Leu Cys Gln Glu Lys
              20                  25                  30        
 Glu Gln Asn Ile Leu Lys Glu Ile Ser Tyr Ala Glu Lys His Gln Asn
          35                  40                  45            
 Gln Asn Arg Ile Asp Gly Leu Asn Lys Thr Leu Ser Glu Ile Arg Ala
      50                  55                  60                
 Asn Cys Ser Asp Ser Gln Leu Arg Ala Asp His Gln Lys Lys Asn Ala
  65                  70                  75                  80
 Lys Gln Lys Asp Glu Gly Ala Glu Arg Gln Gln Asn Leu Ala Glu Ala
                  85                  90                  95    
 Lys Gln Lys Gly Asp Ala Asp
             100            



      <210> 3007
      <211> 116
      <212> PRT
      <213> Homo sapiens


      <400> 3007
 Lys Tyr Ala Leu Thr Leu Val Arg Phe Val Thr Leu Lys Val Gln Ser
   1               5                  10                  15    
 Val Thr Ala Leu Lys Ala Cys Gly Leu Tyr Arg Thr Glu Phe Leu Phe
              20                  25                  30        
 Met Asp Arg Asp Ala Leu Pro Thr Glu Glu Arg Gln Phe Ala Ala Tyr
          35                  40                  45            
 Lys Ala Leu Ala Glu Ala Cys Gly Ser Gln Ala Val Ile Val Arg Thr
      50                  55                  60                
 Met Asp Ile Gly Gly Asp Tyr Glu Leu Pro Tyr Tyr Glu Leu Pro Glu
  65                  70                  75                  80
 Arg Arg Asp Pro Val Ser Ser Ala Gly Ala Leu Phe Val Ser Arg Trp
                  85                  90                  95    
 Ile Val Glu Arg Ser Cys Ala Asp Lys Phe Arg Val Phe Cys Gly Ala
             100                 105                 110        
 Ser Gly Phe Arg
         115    



      <210> 3008
      <211> 432
      <212> PRT
      <213> Homo sapiens


      <400> 3008
 Phe Ile Thr Ala Gln Thr Arg Pro Thr Val Val Ala Ala Asn Gly Glu
   1               5                  10                  15    
 Gly Thr Tyr Leu Asn Val Phe Thr Val His Phe His Ala Thr Asp Lys
              20                  25                  30        
 Val Leu Lys Asp Asp Asn Leu Leu Ala Leu Phe Asp Ile Pro Lys Ile
          35                  40                  45            
 Leu Trp Pro Arg Leu Arg Leu Ser Trp Gln Arg Arg Arg His His Met
      50                  55                  60                
 Ile Thr Gly Arg Met Asp Phe Cys Tyr Arg Leu Ser Ile Met Val Gly
  65                  70                  75                  80
 Gly Asp Glu Ala Val Phe Glu Arg Val Lys Pro Leu Phe Glu Leu Leu
                  85                  90                  95    
 Gly Lys Asn Ile Thr Leu Val Gly Gly Asn Gly Asp Gly Gln Thr Cys
             100                 105                 110        
 Lys Val Ala Asn Gln Ile Ile Val Ala Leu Asn Ile Glu Ala Glu Pro
         115                 120                 125            
 Thr Tyr Leu Arg Lys Arg Val Pro Val Ser Met Asn Cys Leu Asp Ala
     130                 135                 140                
 Ile Leu Leu Gln Ala Glu Val Leu Glu Leu Lys Ala Val Arg Lys Gly
 145                 150                 155                 160
 Met Ala Ser Gly Ala Val Ile Glu Ser Phe Leu Asp Lys Gly Arg Gly
                 165                 170                 175    
 Pro Val Ala Thr Val Leu Val Arg Glu Gly Thr Leu His Lys Gly Asp
             180                 185                 190        
 Ile Val Leu Cys Gly Phe Glu Tyr Gly Arg Val Arg Ala Met Arg Asn
         195                 200                 205            
 Glu Leu Gly Gln Glu Val Leu Glu Ala Gly Pro Ser Ile Pro Val Glu
     210                 215                 220                
 Ile Leu Gly Leu Ser Gly Val Pro Ala Ala Gly Asp Glu Val Thr Val
 225                 230                 235                 240
 Val Arg Asp Glu Lys Lys Ala Arg Glu Val Ala Leu Tyr Arg Gln Gly
                 245                 250                 255    
 Lys Phe Arg Glu Val Lys Leu Ala Arg Gln Gln Lys Ser Lys Leu Glu
             260                 265                 270        
 Asn Met Phe Ala Asn Met Thr Glu Gly Glu Val His Glu Val Asn Ile
         275                 280                 285            
 Val Leu Lys Ala Asp Val Gln Gly Ser Val Glu Ala Ile Ser Asp Ser
     290                 295                 300                
 Leu Leu Lys Leu Ser Thr Asp Glu Val Lys Val Lys Ile Ile Gly Ser
 305                 310                 315                 320
 Gly Val Gly Gly Ile Thr Glu Thr Asp Ala Thr Leu Ala Ala Ala Ser
                 325                 330                 335    
 Asn Ala Ile Leu Glu Gly Leu Phe Thr Leu Thr Leu Asp Arg Tyr Arg
             340                 345                 350        
 Ile Glu Gly Ser Val Leu Gly Lys Ser Arg Ile Val Ile Asp Thr Val
         355                 360                 365            
 Val Cys His Ala Glu Leu Ile Ile Thr Ile Leu His Pro Arg Ile Gly
     370                 375                 380                
 Val Tyr Pro Gly Val Asp Met Leu Ala Phe Lys Val Ala Val Gly Ile
 385                 390                 395                 400
 Val Val Thr Ile Asp Gly Asn Phe Asn Ile Val Arg Phe Pro Asp Leu
                 405                 410                 415    
 Ile Thr Gly Phe Gly Ile Ala Trp Tyr Ser Lys Arg Leu Asn Arg Phe
             420                 425                 430        





      <210> 3009
      <211> 229
      <212> PRT
      <213> Homo sapiens


      <400> 3009
 Leu Val Arg Val Val Glu Phe Leu Leu Asp Leu Val Asp Arg Ser Trp
   1               5                  10                  15    
 Gly Gly Cys Arg Ser Leu His Ser Asn Glu Ala Phe Leu Ala Gln Ala
              20                  25                  30        
 Arg His Ile Leu Ser Ser Val Glu Glu Phe Thr Ala Ala Gln Asp Ser
          35                  40                  45            
 Ser Ala Met Val Gly Glu Asp Val Gly Ser Leu Ala Leu Glu Ser Lys
      50                  55                  60                
 Ser Leu Gln Ser Arg Leu Ala Glu Gln Gln Gln Gln His Ala Arg Glu
  65                  70                  75                  80
 Met Ser Glu Val Thr Ala Glu Leu His His Ala His Lys Glu Leu Asp
                  85                  90                  95    
 Asp Leu Arg Gln His Leu Asp Lys Ser Leu Glu Glu Asn Ser Arg Leu
             100                 105                 110        
 Lys Ser Leu Leu Leu Ser Met Lys Lys Glu Val Lys Ser Ala Asp Thr
         115                 120                 125            
 Ala Ala Thr Leu Asn Leu Gln Ile Ala Gly Leu Gln Thr Ser Val Lys
     130                 135                 140                
 Arg Leu Cys Gly Glu Ile Val Glu Leu Lys Gln His Leu Glu His Tyr
 145                 150                 155                 160
 Asp Lys Ile Gln Glu Leu Thr Gln Met Leu Gln Glu Ser His Ser Ser
                 165                 170                 175    
 Leu Val Ser Thr Asn Glu His Leu Leu Gln Glu Leu Ser Gln Val Arg
             180                 185                 190        
 Ala Gln His Arg Ala Glu Val Glu Gln Met His Trp Ser Tyr Gln Glu
         195                 200                 205            
 Leu Lys Lys Thr Met Ala Leu Phe Pro His Ser Ser Ala Ser His Gly
     210                 215                 220                
 Gly Cys Gln Ala Cys
 225                



      <210> 3010
      <211> 121
      <212> PRT
      <213> Homo sapiens

      <220>
      <221> misc_feature
      <222> (1)...(121)
      <223> Xaa = any amino acid or symbol as shown in the table 8 as set forth in Example 2


      <400> 3010
 Pro Gly Val Ala Leu Pro Gly Arg Cys Arg Gln Ala Pro Ala Asp Leu
   1               5                  10                  15    
 Leu Pro Xaa Met Arg Ala Tyr Trp Pro Asp Val Ile Tyr Ser Phe Ala
              20                  25                  30        
 Asn Arg Ser Arg Phe Trp Lys His Glu Trp Glu Lys His Gly Thr Cys
          35                  40                  45            
 Ala Ala Gln Val Asp Ala Leu Asn Ser Gln Asn Lys Tyr Phe Gly Thr
      50                  55                  60                
 Ser Leu Glu Leu Tyr Arg Glu Leu Asp Leu Asn Ser Val Leu Leu Lys
  65                  70                  75                  80
 Leu Gly Ile Lys Pro Ser Ile Asn Tyr Tyr Gln Val Ala Asp Phe Lys
                  85                  90                  95    
 Asp Ala Leu Ala Arg Val Tyr Gly Val Ile Pro Lys Ile Gln Cys Leu
             100                 105                 110        
 Pro Pro Ser Gln Asp Glu Asp Arg Gln
         115                 120    



      <210> 3011
      <211> 307
      <212> PRT
      <213> Homo sapiens

      <220>
      <221> misc_feature
      <222> (1)...(307)
      <223> Xaa = any amino acid or symbol as shown in the table 8 as set forth in Example 2


      <400> 3011
 Val Val Glu Arg Thr Gly Ala Glu Lys Arg Asp Asp His Ser Ala Gly
   1               5                  10                  15    
 Glu His His Gln Gly Ala Arg Glu Glu Val Pro Gly Gly Ala Glu Gly
              20                  25                  30        
 Gln Glu Ser Gln Ala Asp Pro Ala Val Xaa Pro Ser Trp Ser Ser Gly
          35                  40                  45            
 Pro Ala Pro Ser Pro Thr Xaa Pro Pro Ser Cys Thr Pro Pro Arg Arg
      50                  55                  60                
 Ser Ser Xaa Ala Pro Ala Gly Pro Gln Met Pro Ala Arg Gln Gly Ala
  65                  70                  75                  80
 Pro Cys Trp Pro Ala Thr Ser Gln Arg Pro Pro Lys Thr Ser Tyr Pro
                  85                  90                  95    
 Lys Ala Ser Pro Pro His Glu Lys Glu Pro Leu Ser Pro Leu Ala Pro
             100                 105                 110        
 Gly Ile Xaa Arg Gly Leu Gln Ile Arg Gly Arg Glu Gln Glu Thr Pro
         115                 120                 125            
 Phe Ala Gly Thr Ser Gly Cys Tyr Ala Arg Pro His Pro Ile Ser Ala
     130                 135                 140                
 Gly Xaa Gly Val Arg Arg Gly Pro Pro His Gln Arg Glu Ala Pro Arg
 145                 150                 155                 160
 His Pro Pro His Arg Leu Arg Pro Lys Arg Arg Ala Ala Gln Pro Gly
                 165                 170                 175    
 Pro Arg Lys Ala Ala Gln Gly Pro Arg Arg Gly Gly Thr Ser Asp Pro
             180                 185                 190        
 Pro Arg His Pro Ala Ala Gly Pro Ala Arg Gly Glu Asp Pro Gly Gly
         195                 200                 205            
 Arg Pro Gly Glu Arg Arg Gln Gly Gly Glu Glu Ala Leu Arg Asp Gly
     210                 215                 220                
 Gln Asn Cys Val Lys Pro Ala Val Pro His Pro Ala Leu Ser Met His
 225                 230                 235                 240
 Cys Glu His His Trp Glu Ile Ser Ala Thr Pro Phe Leu Phe Asn Pro
                 245                 250                 255    
 Met His Ala Lys His Phe Ser His Leu Pro Thr His Ser Pro Ser Ala
             260                 265                 270        
 Ser Leu Ala Leu Phe Phe Thr Pro Lys Tyr Asp Arg Val Pro Ala Ala
         275                 280                 285            
 Glu Tyr Val Phe Pro Asn Cys Cys Gly Gln Thr Pro Val Cys Arg Ile
     290                 295                 300                
 Ala Cys Phe
 305        



      <210> 3012
      <211> 800
      <212> PRT
      <213> Homo sapiens


      <400> 3012
 His Gly Gly Ala Thr Phe Ile Asn Ala Phe Val Thr Thr Pro Met Cys
   1               5                  10                  15    
 Cys Pro Ser Arg Ser Ser Met Leu Thr Gly Lys Tyr Val His Asn His
              20                  25                  30        
 Asn Val Tyr Thr Asn Asn Glu Asn Cys Ser Ser Pro Ser Trp Gln Ala
          35                  40                  45            
 Met His Glu Pro Arg Thr Phe Ala Val Tyr Leu Asn Asn Thr Gly Tyr
      50                  55                  60                
 Arg Thr Ala Phe Phe Gly Lys Tyr Leu Asn Glu Tyr Asn Gly Ser Tyr
  65                  70                  75                  80
 Ile Pro Pro Gly Trp Arg Glu Trp Leu Gly Leu Ile Lys Asn Ser Arg
                  85                  90                  95    
 Phe Tyr Asn Tyr Thr Val Cys Arg Asn Gly Ile Lys Glu Lys His Gly
             100                 105                 110        
 Phe Asp Tyr Ala Lys Asp Tyr Phe Thr Asp Leu Ile Thr Asn Glu Ser
         115                 120                 125            
 Ile Asn Tyr Phe Lys Met Ser Lys Arg Met Tyr Pro His Arg Pro Val
     130                 135                 140                
 Met Met Val Ile Ser His Ala Glu Pro His Gly Pro Glu Asp Ser Ala
 145                 150                 155                 160
 Pro Gln Phe Ser Lys Leu Tyr Pro Asn Ala Ser Gln His Ile Thr Pro
                 165                 170                 175    
 Ser Tyr Asn Tyr Ala Pro Asn Met Asp Lys His Trp Ile Met Gln Tyr
             180                 185                 190        
 Thr Gly Pro Met Leu Pro Ile His Met Glu Phe Thr Asn Ile Leu Gln
         195                 200                 205            
 Arg Lys Arg Leu Gln Thr Leu Met Ser Val Asp Asp Ser Val Glu Arg
     210                 215                 220                
 Leu Tyr Asn Met Leu Val Glu Thr Gly Glu Leu Glu Asn Thr Tyr Ile
 225                 230                 235                 240
 Ile Tyr Thr Ala Asp His Gly Tyr His Ile Gly Gln Phe Gly Leu Val
                 245                 250                 255    
 Lys Gly Lys Ser Met Pro Tyr Asp Phe Asp Ile Arg Val Pro Phe Phe
             260                 265                 270        
 Ile Arg Gly Pro Ser Val Glu Pro Gly Ser Ile Val Pro Gln Ile Val
         275                 280                 285            
 Leu Asn Ile Asp Leu Ala Pro Thr Ile Leu Asp Ile Ala Gly Leu Asp
     290                 295                 300                
 Thr Pro Pro Asp Val Asp Gly Lys Ser Val Leu Lys Leu Leu Asp Pro
 305                 310                 315                 320
 Glu Lys Pro Gly Asn Arg Phe Arg Thr Asn Lys Lys Ala Lys Ile Trp
                 325                 330                 335    
 Arg Asp Thr Phe Leu Val Glu Arg Gly Lys Phe Leu Arg Lys Lys Glu
             340                 345                 350        
 Glu Ser Ser Lys Asn Ile Gln Gln Ser Asn His Leu Pro Lys Tyr Glu
         355                 360                 365            
 Arg Val Lys Glu Leu Cys Gln Gln Ala Arg Tyr Gln Thr Ala Cys Glu
     370                 375                 380                
 Gln Pro Gly Gln Lys Trp Gln Cys Ile Glu Asp Thr Ser Gly Lys Leu
 385                 390                 395                 400
 Arg Ile His Lys Cys Lys Gly Pro Ser Asp Leu Leu Thr Val Arg Gln
                 405                 410                 415    
 Ser Thr Arg Asn Leu Tyr Ala Arg Gly Phe His Asp Lys Asp Lys Glu
             420                 425                 430        
 Cys Ser Cys Arg Glu Ser Gly Tyr Arg Ala Ser Arg Ser Gln Arg Lys
         435                 440                 445            
 Ser Gln Arg Gln Phe Leu Arg Asn Gln Gly Thr Pro Lys Tyr Lys Pro
     450                 455                 460                
 Arg Phe Val His Thr Arg Gln Thr Arg Ser Leu Ser Val Glu Phe Glu
 465                 470                 475                 480
 Gly Glu Ile Tyr Asp Ile Asn Leu Glu Glu Glu Glu Glu Leu Gln Val
                 485                 490                 495    
 Leu Gln Pro Arg Asn Ile Ala Lys Arg His Asp Glu Gly His Lys Gly
             500                 505                 510        
 Pro Arg Asp Leu Gln Ala Ser Ser Gly Gly Asn Arg Gly Arg Met Leu
         515                 520                 525            
 Ala Asp Ser Ser Asn Ala Val Gly Pro Pro Thr Thr Val Arg Val Thr
     530                 535                 540                
 His Lys Cys Phe Ile Leu Pro Asn Asp Ser Ile His Cys Glu Arg Glu
 545                 550                 555                 560
 Leu Tyr Gln Ser Ala Arg Ala Trp Lys Asp His Lys Ala Tyr Ile Asp
                 565                 570                 575    
 Glu Glu Ile Glu Ala Leu Gln Asp Lys Ile Lys Asn Leu Arg Glu Val
             580                 585                 590        
 Arg Gly His Leu Lys Arg Arg Lys Pro Glu Glu Cys Ser Cys Ser Lys
         595                 600                 605            
 Gln Ser Tyr Tyr Asn Lys Glu Lys Gly Val Lys Lys Gln Glu Lys Leu
     610                 615                 620                
 Lys Ser His Leu His Pro Phe Lys Glu Ala Ala Gln Glu Val Asp Ser
 625                 630                 635                 640
 Lys Leu Gln Leu Phe Lys Glu Asn Asn Arg Arg Arg Lys Lys Glu Arg
                 645                 650                 655    
 Lys Glu Lys Arg Arg Gln Arg Lys Gly Glu Glu Cys Ser Leu Pro Gly
             660                 665                 670        
 Leu Thr Cys Phe Thr His Asp Asn Asn His Trp Gln Thr Ala Pro Phe
         675                 680                 685            
 Trp Asn Leu Gly Ser Phe Cys Ala Cys Thr Ser Ser Asn Asn Asn Thr
     690                 695                 700                
 Tyr Trp Cys Leu Arg Thr Val Asn Glu Thr His Asn Phe Leu Phe Cys
 705                 710                 715                 720
 Glu Phe Ala Thr Gly Phe Leu Glu Tyr Phe Asp Met Asn Thr Asp Pro
                 725                 730                 735    
 Tyr Gln Leu Thr Asn Thr Val His Thr Val Glu Arg Gly Ile Leu Asn
             740                 745                 750        
 Gln Leu His Val Gln Leu Met Glu Leu Arg Ser Cys Gln Gly Tyr Lys
         755                 760                 765            
 Gln Cys Asn Pro Arg Pro Lys Asn Leu Asp Val Gly Asn Lys Asp Gly
     770                 775                 780                
 Gly Ser Tyr Asp Leu His Arg Gly Gln Leu Trp Asp Gly Trp Glu Gly
 785                 790                 795                 800





      <210> 3013
      <211> 157
      <212> PRT
      <213> Homo sapiens


      <400> 3013
 Gly Pro Arg Met Ala Lys Phe Leu Ser Gln Asp Gln Ile Asn Glu Tyr
   1               5                  10                  15    
 Lys Glu Cys Phe Ser Leu Tyr Asp Lys Gln Gln Arg Gly Lys Ile Lys
              20                  25                  30        
 Ala Thr Asp Leu Met Val Ala Met Arg Cys Leu Gly Ala Ser Pro Thr
          35                  40                  45            
 Pro Gly Glu Val Gln Arg His Leu Gln Thr His Gly Ile Asp Gly Asn
      50                  55                  60                
 Gly Glu Leu Asp Phe Ser Thr Phe Leu Thr Ile Met His Met Gln Ile
  65                  70                  75                  80
 Lys Gln Glu Asp Pro Lys Lys Glu Ile Leu Leu Ala Met Leu Met Val
                  85                  90                  95    
 Asp Lys Glu Lys Lys Gly Tyr Val Met Ala Ser Asp Leu Arg Ser Lys
             100                 105                 110        
 Leu Thr Ser Leu Gly Glu Lys Leu Thr His Lys Glu Val Asp Asp Leu
         115                 120                 125            
 Phe Arg Glu Ala Asp Ile Glu Pro Asn Gly Lys Val Lys Tyr Asp Glu
     130                 135                 140                
 Phe Ile His Lys Ile Thr Ser Tyr Leu Asp Gly Thr Tyr
 145                 150                 155        



      <210> 3014
      <211> 94
      <212> PRT
      <213> Homo sapiens


      <400> 3014
 Phe Gln Gly Gln Arg Met Ala Gly Glu Gln Lys Pro Ser Ser Asn Leu
   1               5                  10                  15    
 Leu Glu Gln Phe Ile Leu Leu Ala Lys Gly Thr Ser Gly Ser Ala Leu
              20                  25                  30        
 Thr Ala Leu Ile Ser Gln Val Leu Glu Ala Pro Gly Val Tyr Val Phe
          35                  40                  45            
 Gly Glu Leu Leu Glu Leu Ala Asn Val Gln Glu Leu Ala Glu Gly Ala
      50                  55                  60                
 Asn Ala Ala Tyr Leu Gln Leu Leu Asn Leu Phe Ala Tyr Gly Thr Tyr
  65                  70                  75                  80
 Pro Asp Tyr Ile Ala Asn Lys Glu Ser Leu Pro Glu Leu Tyr
                  85                  90                



      <210> 3015
      <211> 48
      <212> PRT
      <213> Homo sapiens


      <400> 3015
 Arg Pro Gln Arg Arg Pro Leu Pro Pro Pro Thr Gly Ser Pro Leu Lys
   1               5                  10                  15    
 His Pro Gly Gly Ala Ser Gly Ala Ala Gly Ala Pro Ile Gly Glu Pro
              20                  25                  30        
 Gln His Pro Gly Ala Val Val Ser Val Arg Ala Trp Ser Leu Cys Ser
          35                  40                  45            





      <210> 3016
      <211> 161
      <212> PRT
      <213> Homo sapiens


      <400> 3016
 Glu Val Lys Met Ala Gly Phe Leu Asp Asn Phe Arg Trp Pro Glu Cys
   1               5                  10                  15    
 Glu Cys Ile Asp Trp Ser Glu Arg Arg Asn Ala Val Ala Ser Val Val
              20                  25                  30        
 Ala Gly Ile Leu Phe Phe Thr Gly Trp Trp Ile Met Ile Asp Ala Ala
          35                  40                  45            
 Val Val Tyr Pro Lys Pro Glu Gln Leu Asn His Ala Phe His Thr Cys
      50                  55                  60                
 Gly Val Phe Ser Thr Leu Ala Phe Phe Met Ile Asn Ala Val Ser Asn
  65                  70                  75                  80
 Ala Gln Val Arg Gly Asp Ser Tyr Glu Ser Gly Cys Leu Gly Arg Thr
                  85                  90                  95    
 Gly Ala Arg Val Trp Leu Phe Ile Gly Phe Met Leu Met Phe Gly Ser
             100                 105                 110        
 Leu Ile Ala Ser Met Trp Ile Leu Phe Gly Ala Tyr Val Thr Gln Asn
         115                 120                 125            
 Thr Asp Val Tyr Pro Gly Leu Ala Val Phe Phe Gln Asn Ala Leu Ile
     130                 135                 140                
 Phe Phe Ser Thr Leu Ile Tyr Lys Phe Gly Arg Thr Glu Glu Leu Trp
 145                 150                 155                 160
 Thr
    



      <210> 3017
      <211> 110
      <212> PRT
      <213> Homo sapiens

      <220>
      <221> misc_feature
      <222> (1)...(110)
      <223> Xaa = any amino acid or symbol as shown in the table 8 as set forth in Example 2


      <400> 3017
 Ser Pro Val Leu Gln Arg Ala Phe Lys Asn Gly Pro Gly Thr Ala Asn
   1               5                  10                  15    
 Glu Arg Thr Val Gln Trp Trp Phe Lys Lys Leu Cys Lys Gly Asp Glu
              20                  25                  30        
 Ser Leu Glu Asp Glu Glu His Ser Gly Xaa Pro Ser Glu Ile Tyr Asn
          35                  40                  45            
 Asn Gln Leu Arg Ala Ile Phe Lys Ala Asp Pro Leu Thr Ile Thr Arg
      50                  55                  60                
 Glu Glu Val Phe Pro His Pro Leu Tyr Ser Pro Asp Leu Ser Pro Thr
  65                  70                  75                  80
 Ser Tyr His Phe Phe Gln His Leu Asp Asn Phe Leu Gln Gly Lys Cys
                  85                  90                  95    
 Phe His Tyr Gln Gln Asp Ala Glu His Ala Phe Gln Glu Phe
             100                 105                 110



      <210> 3018
      <211> 358
      <212> PRT
      <213> Homo sapiens

      <220>
      <221> misc_feature
      <222> (1)...(358)
      <223> Xaa = any amino acid or symbol as shown in the table 8 as set forth in Example 2


      <400> 3018
 Gly Thr Glu Pro Gly Thr Gly Gly Pro Gly Pro Xaa Gly Ser Ala Ser
   1               5                  10                  15    
 Ser Ser Ala His Glu Ala Met Xaa Leu Leu Gly Trp Gly Ser Lys Ala
              20                  25                  30        
 Glu Pro Gly Ser Glu Ala Xaa Ser Trp Lys Leu Ala Glu Lys Val Trp
          35                  40                  45            
 Glu Ala Gln Leu Pro Gly Phe Pro Ser Pro Pro Gln Cys Ser Val Arg
      50                  55                  60                
 Cys Gly Arg Gly Gln Arg Ser Arg Gln Val Arg Cys Val Gly Asn Asn
  65                  70                  75                  80
 Gly Asp Glu Val Ser Glu Gln Glu Cys Ala Ser Gly Pro Pro Gln Pro
                  85                  90                  95    
 Pro Ser Arg Glu Ala Cys Asp Met Gly Pro Cys Thr Thr Ala Trp Phe
             100                 105                 110        
 His Ser Asp Trp Ser Ser Lys Cys Ser Ala Glu Cys Gly Thr Gly Ile
         115                 120                 125            
 Gln Arg Arg Ser Val Val Cys Leu Gly Ser Gly Ala Ala Leu Gly Pro
     130                 135                 140                
 Gly Gln Gly Glu Ala Gly Ala Gly Thr Gly Gln Ser Cys Pro Thr Gly
 145                 150                 155                 160
 Ser Arg Pro Pro Asp Met Arg Ala Cys Ser Leu Gly Pro Cys Glu Arg
                 165                 170                 175    
 Thr Trp Arg Trp Tyr Thr Gly Pro Trp Gly Glu Cys Ser Ser Glu Cys
             180                 185                 190        
 Gly Ser Gly Thr Gln Arg Arg Asp Ile Ile Cys Val Ser Lys Leu Gly
         195                 200                 205            
 Thr Glu Phe Asn Val Thr Ser Pro Ser Asn Cys Ser His Leu Pro Arg
     210                 215                 220                
 Pro Pro Ala Leu Gln Pro Cys Gln Gly Gln Ala Cys Gln Asp Arg Trp
 225                 230                 235                 240
 Phe Ser Thr Pro Trp Ser Pro Cys Ser Arg Ser Cys Gln Gly Gly Thr
                 245                 250                 255    
 Gln Thr Arg Glu Val Gln Cys Leu Ser Thr Asn Gln Thr Leu Ser Thr
             260                 265                 270        
 Arg Cys Pro Pro Gln Leu Arg Pro Ser Arg Lys Arg Pro Cys Asn Ser
         275                 280                 285            
 Gln Pro Cys Ser Gln Arg Pro Asp Asp Gln Cys Lys Asp Ser Ser Pro
     290                 295                 300                
 His Cys Pro Leu Val Val Gln Ala Arg Leu Cys Val Tyr Pro Tyr Tyr
 305                 310                 315                 320
 Thr Ala Thr Cys Cys Arg Ser Cys Ala His Val Leu Glu Arg Ser Pro
                 325                 330                 335    
 Gln Asp Pro Ser Xaa Lys Gly Ser Gly Ala Pro Ser Arg Phe Ser Val
             340                 345                 350        
 Pro Pro Ser Val Thr His
         355            



      <210> 3019
      <211> 433
      <212> PRT
      <213> Homo sapiens

      <220>
      <221> misc_feature
      <222> (1)...(433)
      <223> Xaa = any amino acid or symbol as shown in the table 8 as set forth in Example 2


      <400> 3019
 Met Ser Ser Lys Gly Ser Val Val Leu Ala Tyr Ser Gly Gly Leu Asp
   1               5                  10                  15    
 Thr Ser Cys Ile Leu Val Trp Leu Lys Glu Gln Gly Tyr Asp Val Ile
              20                  25                  30        
 Ala Tyr Leu Ala Asn Ile Gly Gln Lys Glu Asp Phe Glu Glu Ala Arg
          35                  40                  45            
 Lys Lys Ala Leu Lys Leu Gly Ala Lys Lys Val Phe Ile Glu Asp Val
      50                  55                  60                
 Ser Arg Glu Phe Val Glu Glu Phe Ile Trp Pro Ala Ile Gln Ser Ser
  65                  70                  75                  80
 Ala Leu Tyr Glu Asp Arg Tyr Leu Leu Gly Thr Phe Phe Ala Arg Pro
                  85                  90                  95    
 Cys Ile Ala Arg Lys Gln Val Glu Ile Ala Gln Arg Glu Gly Ala Lys
             100                 105                 110        
 Tyr Val Ser His Gly Ala Thr Gly Lys Gly Asn Asp Gln Val Arg Phe
         115                 120                 125            
 Glu Leu Ser Cys Tyr Ser Leu Ala Pro Gln Ile Lys Val Ile Ala Pro
     130                 135                 140                
 Trp Arg Met Pro Glu Phe Tyr Asn Arg Phe Lys Gly Arg Asn Asp Leu
 145                 150                 155                 160
 Met Glu Tyr Ala Lys Gln His Gly Ile Pro Ile Pro Val Thr Pro Lys
                 165                 170                 175    
 Asn Pro Trp Ser Met Asp Glu Asn Leu Met His Ile Ser Tyr Glu Ala
             180                 185                 190        
 Gly Ile Leu Glu Asn Pro Lys Asn Gln Ala Pro Pro Gly Leu Tyr Thr
         195                 200                 205            
 Lys Thr Gln Asp Pro Ala Lys Ala Pro Asn Thr Pro Asp Ile Leu Glu
     210                 215                 220                
 Ile Glu Phe Lys Lys Gly Val Pro Val Glu Gly Gly Pro Thr Phe Lys
 225                 230                 235                 240
 Asp Gly Thr Thr His Gln Thr Phe Leu Glu Leu Phe Met Tyr Leu Asn
                 245                 250                 255    
 Glu Val Ala Gly Lys His Gly Val Gly Pro Tyr Leu Thr Ser Trp Glu
             260                 265                 270        
 Asn Arg Phe His Trp Glu Leu Lys Ser Arg Gly Ile Leu Arg Arg Pro
         275                 280                 285            
 Gln Ala Gly Thr Ile Leu Tyr His Ala His Leu Asp Ile Glu Ala Phe
     290                 295                 300                
 Thr Met Gly Gly Asp Arg Ala Gln Ile Pro Asn Gln Gly Leu Gly Phe
 305                 310                 315                 320
 Glu Phe Val Glu Leu Gly Val Tyr Arg Phe Ser Gly Thr Ala Pro Glu
                 325                 330                 335    
 Cys Glu Leu Val Gly Pro Cys Leu Arg Gln Ser Pro Gln Glu Arg Val
             340                 345                 350        
 Glu Gly Lys Ser Ala Gly Val Pro Ser Leu Lys Gly Pro Arg Cys Thr
         355                 360                 365            
 Ser Leu Gly Pro Glu Val Pro His Cys Ser Leu Tyr Asn Glu Glu Leu
     370                 375                 380                
 Val Lys His Gly Thr Cys Gln Gly Asp Tyr Glu Pro Asn Xaa Leu Pro
 385                 390                 395                 400
 Pro Gly Phe Ile Gln Thr Ser Ile Ser Leu Lys Ala Glu Gly Asn Tyr
                 405                 410                 415    
 His Arg Leu Pro Arg Ala Lys Val Thr Ala Gln Ile Arg Pro Arg Val
             420                 425                 430        
 Gln
    



      <210> 3020
      <211> 194
      <212> PRT
      <213> Homo sapiens

      <220>
      <221> misc_feature
      <222> (1)...(194)
      <223> Xaa = any amino acid or symbol as shown in the table 8 as set forth in Example 2


      <400> 3020
 Leu Ala Leu Ser Gly Glu Met Thr Leu Val Leu Phe Met Leu Leu Ala
   1               5                  10                  15    
 Gly Gly Trp Val Thr His Asp Lys Pro Glu Pro Met Pro Arg Ala Ala
              20                  25                  30        
 Thr Ser Gly Gly Thr Arg Lys Gly Lys Thr Lys Ala Ala Leu Lys Asp
          35                  40                  45            
 Leu Ile Ala Thr Trp Lys Glu Val Cys Val Ser Ser Pro Ala Thr Glu
      50                  55                  60                
 Gln Ser Trp Met Glu Asn Asp Phe Asp Glu Leu Thr Glu Val Gly Phe
  65                  70                  75                  80
 Arg Arg Ser Val Ile Thr Asn Phe Phe Lys Leu Lys Glu Tyr Val Leu
                  85                  90                  95    
 Thr His His Lys Glu Ala Lys Asn Leu Glu Lys Met Leu Asp Glu Trp
             100                 105                 110        
 Leu Thr Arg Ile Asn Ser Val Glu Lys Thr Leu Asn Asp Leu Met Glu
         115                 120                 125            
 Leu Lys Asn Met Ala Xaa Glu Leu Thr Glu Val Gly Phe Arg Arg Ser
     130                 135                 140                
 Val Ile Thr Asn Phe Phe Lys Leu Lys Glu Tyr Val Leu Thr His His
 145                 150                 155                 160
 Lys Glu Ala Lys Asn Leu Glu Lys Met Leu Asp Glu Trp Leu Thr Arg
                 165                 170                 175    
 Ile Asn Ser Val Glu Lys Thr Leu Asn Asp Leu Met Glu Leu Lys Asn
             180                 185                 190        
 Met Ala
        



      <210> 3021
      <211> 677
      <212> PRT
      <213> Homo sapiens


      <400> 3021
 Leu Trp His Thr Ser His Pro Phe Val Gln Pro Leu Phe Pro Gln Arg
   1               5                  10                  15    
 Arg Ala Ala Phe Leu Gly Ile Ser Val Val His Phe Ser His Leu Pro
              20                  25                  30        
 Cys Cys His Leu Lys Val Asn Ile Leu Val Leu Leu Arg Lys Pro Phe
          35                  40                  45            
 Pro Ser Phe Gly Met Asn Ser Asn Phe Ile Thr Phe Asp Leu Lys Met
      50                  55                  60                
 Ser Leu Leu Pro Ser Asn Leu Phe Ser Ala Phe Ile Thr Leu Cys Phe
  65                  70                  75                  80
 Gly Ala Ile Phe Phe Leu Pro Asp Ser Ser Lys Leu Leu Ser Gly Val
                  85                  90                  95    
 Leu Phe His Ser Ser Pro Ala Leu Gln Pro Ala Ala Asp His Lys Pro
             100                 105                 110        
 Gly Pro Gly Ala Arg Ala Glu Asp Ala Ala Glu Gly Arg Ala Arg Arg
         115                 120                 125            
 Arg Glu Glu Gly Ala Pro Gly Asp Pro Glu Ala Ala Leu Glu Asp Asn
     130                 135                 140                
 Leu Ala Arg Ile Arg Glu Asn His Glu Arg Ala Leu Arg Glu Ala Lys
 145                 150                 155                 160
 Glu Thr Leu Gln Lys Leu Pro Glu Glu Ile Gln Arg Asp Ile Leu Leu
                 165                 170                 175    
 Glu Lys Lys Lys Val Ala Gln Asp Gln Leu Arg Asp Lys Ala Pro Phe
             180                 185                 190        
 Arg Gly Leu Pro Pro Val Asp Phe Val Pro Pro Ile Gly Val Glu Ser
         195                 200                 205            
 Arg Glu Pro Ala Asp Ala Ala Ile Arg Glu Lys Arg Ala Lys Ile Lys
     210                 215                 220                
 Glu Met Met Lys His Ala Trp Asn Asn Tyr Lys Gly Tyr Ala Trp Gly
 225                 230                 235                 240
 Leu Asn Glu Leu Lys Pro Ile Ser Lys Gly Gly His Ser Ser Ser Leu
                 245                 250                 255    
 Phe Gly Asn Ile Lys Gly Ala Thr Ile Val Asp Ala Leu Asp Thr Leu
             260                 265                 270        
 Phe Ile Met Glu Met Lys His Glu Phe Glu Glu Ala Lys Ser Trp Val
         275                 280                 285            
 Glu Glu Asn Leu Asp Phe Asn Val Asn Ala Glu Ile Ser Val Phe Glu
     290                 295                 300                
 Val Asn Ile Arg Phe Val Gly Gly Leu Leu Ser Ala Tyr Tyr Leu Ser
 305                 310                 315                 320
 Gly Glu Glu Ile Phe Arg Lys Lys Ala Val Glu Leu Gly Val Lys Leu
                 325                 330                 335    
 Leu Pro Ala Phe His Thr Pro Ser Gly Ile Pro Trp Ala Leu Leu Asn
             340                 345                 350        
 Met Lys Ser Gly Ile Gly Arg Asn Trp Pro Trp Ala Ser Gly Gly Ser
         355                 360                 365            
 Ser Ile Leu Ala Glu Phe Gly Thr Leu His Leu Glu Phe Met His Leu
     370                 375                 380                
 Ser His Leu Ser Gly Asn Pro Ile Phe Ala Glu Lys Val Met Asn Ile
 385                 390                 395                 400
 Arg Thr Val Leu Asn Lys Leu Glu Lys Pro Gln Gly Leu Tyr Pro Asn
                 405                 410                 415    
 Tyr Leu Asn Pro Ser Ser Gly Gln Trp Gly Gln His His Val Ser Val
             420                 425                 430        
 Gly Gly Leu Gly Asp Ser Phe Tyr Glu Tyr Leu Leu Lys Ala Trp Leu
         435                 440                 445            
 Met Ser Asp Lys Thr Asp Leu Glu Ala Lys Lys Met Tyr Phe Asp Ala
     450                 455                 460                
 Val Gln Ala Ile Glu Thr His Leu Ile Arg Lys Ser Ser Ser Gly Leu
 465                 470                 475                 480
 Thr Tyr Ile Ala Glu Trp Lys Gly Gly Leu Leu Glu His Lys Met Gly
                 485                 490                 495    
 His Leu Thr Cys Phe Ala Gly Gly Met Phe Ala Leu Gly Ala Asp Ala
             500                 505                 510        
 Ala Pro Glu Gly Met Ala Gln His Tyr Leu Glu Leu Gly Ala Glu Ile
         515                 520                 525            
 Ala Arg Thr Cys His Glu Ser Tyr Asn Arg Thr Phe Met Lys Leu Gly
     530                 535                 540                
 Pro Glu Ala Phe Arg Phe Asp Gly Gly Val Glu Ala Ile Ala Thr Arg
 545                 550                 555                 560
 Gln Asn Glu Lys Tyr Tyr Ile Leu Arg Pro Glu Val Met Glu Thr Tyr
                 565                 570                 575    
 Met Tyr Met Trp Arg Leu Thr His Asp Pro Lys Tyr Arg Lys Trp Ala
             580                 585                 590        
 Trp Glu Ala Val Glu Ala Leu Glu Asn His Cys Arg Val Asn Gly Gly
         595                 600                 605            
 Tyr Ser Gly Leu Arg Asp Val Tyr Leu Leu His Glu Ser Tyr Asp Asp
     610                 615                 620                
 Val Gln Gln Ser Phe Phe Leu Ala Glu Thr Leu Lys Tyr Leu Tyr Leu
 625                 630                 635                 640
 Ile Phe Ser Asp Asp Asp Leu Leu Pro Leu Glu His Trp Ile Phe Asn
                 645                 650                 655    
 Ser Glu Ala His Leu Leu Pro Ile Leu Pro Lys Asp Lys Lys Glu Val
             660                 665                 670        
 Glu Ile Arg Glu Glu
         675        



      <210> 3022
      <211> 1188
      <212> PRT
      <213> Homo sapiens


      <400> 3022
 Met Asp Leu Pro Arg Gly Leu Val Val Ala Trp Ala Leu Ser Leu Trp
   1               5                  10                  15    
 Pro Gly Phe Thr Asp Thr Phe Asn Met Asp Thr Arg Lys Pro Arg Val
              20                  25                  30        
 Ile Pro Gly Ser Arg Thr Ala Phe Phe Gly Tyr Thr Val Gln Gln His
          35                  40                  45            
 Asp Ile Ser Gly Asn Lys Trp Leu Val Val Gly Ala Pro Leu Glu Thr
      50                  55                  60                
 Asn Gly Tyr Gln Lys Thr Gly Asp Val Tyr Lys Cys Pro Val Ile His
  65                  70                  75                  80
 Gly Asn Cys Thr Lys Leu Asn Leu Gly Arg Val Thr Leu Ser Asn Val
                  85                  90                  95    
 Ser Glu Arg Lys Asp Asn Met Arg Leu Gly Leu Ser Leu Ala Thr Asn
             100                 105                 110        
 Pro Lys Asp Asn Ser Phe Leu Ala Cys Ser Pro Leu Trp Ser His Glu
         115                 120                 125            
 Cys Gly Ser Ser Tyr Tyr Thr Thr Gly Met Cys Ser Arg Val Asn Ser
     130                 135                 140                
 Asn Phe Arg Phe Ser Lys Thr Val Ala Pro Ala Leu Gln Arg Cys Gln
 145                 150                 155                 160
 Thr Tyr Met Asp Ile Val Ile Val Leu Asp Gly Ser Asn Ser Ile Tyr
                 165                 170                 175    
 Pro Trp Val Glu Val Gln His Phe Leu Ile Asn Ile Leu Lys Lys Phe
             180                 185                 190        
 Tyr Ile Gly Pro Gly Gln Ile Gln Val Gly Val Val Gln Tyr Gly Glu
         195                 200                 205            
 Asp Val Val His Glu Phe His Leu Asn Asp Tyr Arg Ser Val Lys Asp
     210                 215                 220                
 Val Val Glu Ala Ala Ser His Ile Glu Gln Arg Gly Gly Thr Glu Thr
 225                 230                 235                 240
 Arg Thr Ala Phe Gly Ile Glu Phe Ala Arg Ser Glu Ala Phe Gln Lys
                 245                 250                 255    
 Gly Gly Arg Lys Gly Ala Lys Lys Val Met Ile Val Ile Thr Asp Gly
             260                 265                 270        
 Glu Ser His Asp Ser Pro Asp Leu Glu Lys Val Ile Gln Gln Ser Glu
         275                 280                 285            
 Arg Asp Asn Val Thr Arg Tyr Ala Val Ala Val Leu Gly Tyr Tyr Asn
     290                 295                 300                
 Arg Arg Gly Ile Asn Pro Glu Thr Phe Leu Asn Glu Ile Lys Tyr Ile
 305                 310                 315                 320
 Ala Ser Asp Pro Asp Asp Lys His Phe Phe Asn Val Thr Asp Glu Ala
                 325                 330                 335    
 Ala Leu Lys Asp Ile Val Asp Ala Leu Gly Asp Arg Ile Phe Ser Leu
             340                 345                 350        
 Glu Gly Thr Asn Lys Asn Glu Thr Ser Phe Gly Leu Glu Met Ser Gln
         355                 360                 365            
 Thr Gly Phe Ser Ser His Val Val Glu Asp Gly Val Leu Leu Gly Ala
     370                 375                 380                
 Val Gly Ala Tyr Asp Trp Asn Gly Ala Val Leu Lys Glu Thr Ser Ala
 385                 390                 395                 400
 Gly Lys Val Ile Pro Leu Arg Glu Ser Tyr Leu Lys Glu Phe Pro Glu
                 405                 410                 415    
 Glu Leu Lys Asn His Gly Ala Tyr Leu Gly Tyr Thr Val Thr Ser Val
             420                 425                 430        
 Val Ser Ser Arg Gln Gly Arg Val Tyr Val Ala Gly Ala Pro Arg Phe
         435                 440                 445            
 Asn His Thr Gly Lys Val Ile Leu Phe Thr Met His Asn Asn Arg Ser
     450                 455                 460                
 Leu Thr Ile His Gln Ala Met Arg Gly Gln Gln Ile Gly Ser Tyr Phe
 465                 470                 475                 480
 Gly Ser Glu Ile Thr Ser Val Asp Ile Asp Gly Asp Gly Val Thr Asp
                 485                 490                 495    
 Val Leu Leu Val Gly Ala Pro Met Tyr Phe Asn Glu Gly Arg Glu Arg
             500                 505                 510        
 Gly Lys Val Tyr Val Tyr Glu Leu Arg Gln Asn Arg Phe Val Tyr Asn
         515                 520                 525            
 Gly Thr Leu Lys Asp Ser His Ser Tyr Gln Asn Ala Arg Phe Gly Ser
     530                 535                 540                
 Ser Ile Ala Ser Val Arg Asp Leu Asn Gln Asp Ser Tyr Asn Asp Val
 545                 550                 555                 560
 Val Val Gly Ala Pro Leu Glu Asp Asn His Ala Gly Ala Ile Tyr Ile
                 565                 570                 575    
 Phe His Gly Phe Arg Gly Ser Ile Leu Lys Thr Pro Lys Gln Arg Ile
             580                 585                 590        
 Thr Ala Ser Glu Leu Ala Thr Gly Leu Gln Tyr Phe Gly Cys Ser Ile
         595                 600                 605            
 His Gly Gln Leu Asp Leu Asn Glu Asp Gly Leu Ile Asp Leu Ala Val
     610                 615                 620                
 Gly Ala Leu Gly Asn Ala Val Ile Leu Trp Ser Arg Pro Val Val Gln
 625                 630                 635                 640
 Ile Asn Ala Ser Leu His Phe Glu Pro Ser Lys Ile Asn Ile Phe His
                 645                 650                 655    
 Arg Asp Cys Lys Arg Ser Gly Arg Asp Ala Thr Cys Leu Ala Ala Phe
             660                 665                 670        
 Leu Cys Phe Thr Pro Ile Phe Leu Ala Pro His Phe Gln Thr Thr Thr
         675                 680                 685            
 Val Gly Ile Arg Tyr Asn Ala Thr Met Asp Glu Arg Arg Tyr Thr Pro
     690                 695                 700                
 Arg Ala His Leu Asp Glu Gly Gly Asp Arg Phe Thr Asn Arg Ala Val
 705                 710                 715                 720
 Leu Leu Ser Ser Gly Gln Glu Leu Cys Glu Arg Ile Asn Phe His Val
                 725                 730                 735    
 Leu Asp Thr Ala Asp Tyr Val Lys Pro Val Thr Phe Ser Val Glu Tyr
             740                 745                 750        
 Ser Leu Glu Asp Pro Asp His Gly Pro Met Leu Asp Asp Gly Trp Pro
         755                 760                 765            
 Thr Thr Leu Arg Val Ser Val Pro Phe Trp Asn Gly Cys Asn Glu Asp
     770                 775                 780                
 Glu His Cys Val Pro Asp Leu Val Leu Asp Ala Arg Ser Asp Leu Pro
 785                 790                 795                 800
 Thr Ala Met Glu Tyr Cys Gln Arg Val Leu Arg Lys Pro Ala Gln Asp
                 805                 810                 815    
 Cys Ser Ala Tyr Thr Leu Ser Phe Asp Thr Thr Val Phe Ile Ile Glu
             820                 825                 830        
 Ser Thr Arg Gln Arg Val Ala Val Glu Ala Thr Leu Glu Asn Arg Gly
         835                 840                 845            
 Glu Asn Ala Tyr Ser Thr Val Leu Asn Ile Ser Gln Ser Ala Asn Leu
     850                 855                 860                
 Gln Phe Ala Ser Leu Ile Gln Lys Glu Asp Ser Asp Gly Ser Ile Glu
 865                 870                 875                 880
 Cys Val Asn Glu Glu Arg Arg Leu Gln Lys Gln Val Cys Asn Val Ser
                 885                 890                 895    
 Tyr Pro Phe Phe Arg Ala Lys Ala Lys Val Ala Phe Arg Leu Asp Phe
             900                 905                 910        
 Glu Phe Ser Lys Ser Ile Phe Leu His His Leu Glu Ile Glu Leu Ala
         915                 920                 925            
 Ala Gly Ser Asp Ser Asn Glu Arg Asp Ser Thr Lys Glu Asp Asn Val
     930                 935                 940                
 Ala Pro Leu Arg Phe His Leu Lys Tyr Glu Val Asp Val Leu Phe Thr
 945                 950                 955                 960
 Arg Ser Ser Ser Leu Ser His Tyr Glu Val Lys Pro Asn Ser Ser Leu
                 965                 970                 975    
 Glu Arg Tyr Asp Gly Ile Gly Pro Pro Phe Ser Cys Ile Phe Arg Ile
             980                 985                 990        
 Gln Asn Leu Gly Leu Phe Pro Ile His Gly Met Met Met Lys Ile Thr
         995                1000                1005            
 Ile Pro Ile Ala Thr Arg Ser Gly Asn Arg Leu Leu Lys Leu Arg Asp
    1010                1015                1020                
 Phe Leu Thr Asp Glu Ala Asn Thr Ser Cys Asn Ile Trp Gly Asn Ser
1025                1030                1035                1040
 Thr Glu Tyr Arg Pro Thr Pro Val Glu Glu Asp Leu Arg Arg Ala Pro
                1045                1050                1055    
 Gln Leu Asn His Ser Asn Ser Asp Val Val Ser Ile Asn Cys Asn Ile
            1060                1065                1070        
 Arg Leu Val Pro Asn Gln Glu Ile Asn Phe His Leu Leu Gly Asn Leu
        1075                1080                1085            
 Trp Leu Arg Ser Leu Lys Ala Leu Lys Tyr Lys Ser Met Lys Ile Met
    1090                1095                1100                
 Val Asn Ala Ala Leu Gln Arg Gln Phe His Ser Pro Phe Ile Phe Arg
1105                1110                1115                1120
 Glu Glu Asp Pro Ser Arg Gln Ile Val Phe Glu Ile Ser Lys Gln Glu
                1125                1130                1135    
 Asp Trp Gln Val Pro Ile Trp Ile Ile Val Gly Ser Thr Leu Gly Gly
            1140                1145                1150        
 Leu Leu Leu Leu Ala Leu Leu Val Leu Ala Leu Trp Lys Leu Gly Phe
        1155                1160                1165            
 Phe Arg Ser Ala Arg Arg Arg Arg Glu Pro Gly Leu Asp Pro Thr Pro
    1170                1175                1180                
 Lys Val Leu Glu
1185            



      <210> 3023
      <211> 853
      <212> PRT
      <213> Homo sapiens

      <220>
      <221> misc_feature
      <222> (1)...(853)
      <223> Xaa = any amino acid or symbol as shown in the table 8 as set forth in Example 2


      <400> 3023
 Gln Ser Arg Ala Arg Ala Asp Gln Arg Ile Thr Glu Ser Arg Gln Val
   1               5                  10                  15    
 Val Glu Leu Ala Val Lys Glu His Lys Ala Glu Ile Leu Ala Leu Gln
              20                  25                  30        
 Gln Ala Leu Lys Glu Gln Lys Leu Lys Ala Glu Ser Leu Ser Asp Lys
          35                  40                  45            
 Leu Asn Asp Leu Glu Lys Lys His Ala Met Leu Glu Met Asn Ala Arg
      50                  55                  60                
 Ser Leu Gln Gln Lys Leu Glu Thr Glu Arg Glu Leu Lys Gln Arg Leu
  65                  70                  75                  80
 Leu Glu Glu Gln Ala Lys Leu Gln Gln Gln Met Asp Leu Gln Lys Asn
                  85                  90                  95    
 His Ile Phe Arg Leu Thr Gln Gly Leu Gln Glu Ala Leu Asp Arg Ala
             100                 105                 110        
 Asp Leu Leu Lys Thr Glu Arg Ser Asp Leu Glu Tyr Gln Leu Glu Asn
         115                 120                 125            
 Ile Gln Val Leu Tyr Ser His Glu Lys Val Lys Met Glu Gly Thr Ile
     130                 135                 140                
 Ser Gln Gln Thr Lys Leu Ile Asp Phe Leu Gln Ala Lys Met Asp Gln
 145                 150                 155                 160
 Pro Ala Lys Lys Lys Lys Val Pro Leu Gln Tyr Asn Glu Leu Lys Leu
                 165                 170                 175    
 Ala Leu Glu Lys Glu Lys Ala Arg Cys Ala Glu Leu Glu Glu Ala Leu
             180                 185                 190        
 Gln Lys Thr Arg Ile Glu Leu Arg Ser Ala Arg Glu Glu Ala Ala His
         195                 200                 205            
 Arg Lys Ala Thr Asp His Pro His Pro Ser Thr Pro Ala Thr Ala Arg
     210                 215                 220                
 Gln Gln Ile Ala Met Ser Ala Ile Val Arg Ser Pro Glu His Gln Pro
 225                 230                 235                 240
 Ser Ala Met Ser Leu Leu Ala Pro Pro Ser Ser Arg Arg Lys Glu Ser
                 245                 250                 255    
 Ser Thr Pro Glu Glu Phe Ser Arg Arg Leu Lys Glu Arg Met His His
             260                 265                 270        
 Asn Ile Pro His Arg Phe Asn Val Gly Leu Asn Met Arg Ala Thr Lys
         275                 280                 285            
 Cys Ala Val Cys Leu Asp Thr Val His Phe Gly Arg Gln Ala Ser Lys
     290                 295                 300                
 Cys Leu Glu Cys Gln Val Met Cys His Pro Lys Cys Ser Thr Cys Leu
 305                 310                 315                 320
 Pro Ala Thr Cys Gly Leu Pro Ala Glu Tyr Val Thr His Phe Thr Glu
                 325                 330                 335    
 Ala Phe Cys Arg Asp Lys Met Asn Ser Pro Gly Leu Gln Thr Lys Glu
             340                 345                 350        
 Pro Ser Ser Ser Leu His Leu Glu Gly Trp Met Lys Val Pro Arg Asn
         355                 360                 365            
 Asn Lys Arg Gly Gln Gln Gly Trp Asp Arg Lys Tyr Ile Val Leu Glu
     370                 375                 380                
 Gly Ser Lys Val Leu Ile Tyr Asp Asn Glu Ala Arg Glu Ala Gly Gln
 385                 390                 395                 400
 Arg Pro Val Glu Glu Phe Glu Leu Cys Leu Pro Asp Gly Asp Val Ser
                 405                 410                 415    
 Ile His Gly Ala Val Gly Ala Ser Glu Leu Ala Asn Thr Ala Lys Ala
             420                 425                 430        
 Asp Val Pro Tyr Ile Leu Lys Met Glu Ser His Pro His Thr Thr Cys
         435                 440                 445            
 Trp Pro Gly Arg Thr Leu Tyr Leu Leu Ala Pro Ser Phe Pro Asp Lys
     450                 455                 460                
 Gln Arg Trp Val Thr Ala Leu Glu Ser Val Val Ala Gly Gly Arg Val
 465                 470                 475                 480
 Ser Arg Glu Lys Ala Glu Ala Asp Ala Lys Leu Leu Gly Asn Ser Leu
                 485                 490                 495    
 Leu Lys Leu Glu Gly Asp Asp Arg Leu Asp Met Asn Cys Thr Leu Pro
             500                 505                 510        
 Phe Ser Asp Gln Val Val Leu Val Gly Thr Glu Glu Gly Leu Tyr Ala
         515                 520                 525            
 Leu Asn Val Leu Lys Asn Ser Leu Thr His Val Pro Gly Ile Gly Ala
     530                 535                 540                
 Val Phe Gln Ile Tyr Ile Ile Lys Asp Leu Glu Lys Leu Leu Met Ile
 545                 550                 555                 560
 Ala Gly Glu Glu Arg Ala Leu Cys Leu Val Asp Val Lys Lys Val Lys
                 565                 570                 575    
 Gln Ser Leu Ala Gln Ser His Leu Pro Ala Gln Pro Asp Ile Ser Pro
             580                 585                 590        
 Asn Ile Phe Glu Ala Val Lys Gly Cys His Leu Phe Gly Ala Gly Lys
         595                 600                 605            
 Ile Glu Asn Gly Leu Cys Ile Cys Ala Ala Met Pro Ser Lys Val Val
     610                 615                 620                
 Ile Leu Arg Tyr Asn Glu Asn Leu Ser Lys Tyr Cys Ile Arg Lys Glu
 625                 630                 635                 640
 Ile Glu Thr Ser Glu Pro Cys Ser Cys Ile His Phe Thr Asn Tyr Ser
                 645                 650                 655    
 Ile Leu Ile Gly Thr Asn Lys Phe Tyr Glu Ile Asp Met Lys Gln Tyr
             660                 665                 670        
 Thr Leu Glu Glu Phe Leu Asp Lys Asn Asp His Ser Leu Ala Pro Ala
         675                 680                 685            
 Val Phe Ala Ala Ser Ser Asn Ser Phe Pro Val Ser Ile Val Gln Val
     690                 695                 700                
 Asn Ser Ala Gly Gln Arg Glu Glu Tyr Leu Leu Cys Phe His Glu Phe
 705                 710                 715                 720
 Gly Val Phe Val Asp Ser Tyr Gly Arg Arg Ser Arg Thr Asp Asp Leu
                 725                 730                 735    
 Lys Trp Ser Arg Leu Pro Leu Ala Phe Ala Tyr Arg Glu Pro Tyr Leu
             740                 745                 750        
 Phe Val Thr His Phe Asn Ser Leu Glu Val Ile Glu Ile Gln Ala Arg
         755                 760                 765            
 Ser Ser Ala Gly Thr Pro Ala Arg Ala Tyr Leu Asp Ile Pro Asn Pro
     770                 775                 780                
 Arg Tyr Leu Gly Pro Ala Ile Ser Ser Gly Ala Ile Tyr Leu Ala Ser
 785                 790                 795                 800
 Ser Tyr Gln Asp Lys Leu Arg Val Ile Cys Cys Lys Gly Asn Leu Val
                 805                 810                 815    
 Lys Glu Ser Gly Thr Glu His His Arg Gly Pro Ser Thr Ser Arg Arg
             820                 825                 830        
 Xaa Pro Ala Ser Pro Leu Pro Gln Tyr Gln Gly Gln Arg Ala Phe Leu
         835                 840                 845            
 Gln Gly Arg Arg Lys
     850            



      <210> 3024
      <211> 236
      <212> PRT
      <213> Homo sapiens


      <400> 3024
 Pro Gly Leu Ser Gln Glu Pro Ser Gly Ser Met Glu Thr Val Val Ile
   1               5                  10                  15    
 Val Ala Ile Gly Val Leu Ala Thr Ile Phe Leu Ala Ser Phe Ala Ala
              20                  25                  30        
 Leu Val Leu Val Cys Arg Gln Arg Tyr Cys Arg Pro Arg Asp Leu Leu
          35                  40                  45            
 Gln Arg Tyr Asp Ser Lys Pro Ile Val Asp Leu Ile Gly Ala Met Glu
      50                  55                  60                
 Thr Gln Ser Glu Pro Ser Glu Leu Glu Leu Asp Asp Val Val Ile Thr
  65                  70                  75                  80
 Asn Pro His Ile Glu Ala Ile Leu Glu Asn Glu Asp Trp Ile Glu Asp
                  85                  90                  95    
 Ala Ser Gly Leu Met Ser His Cys Ile Ala Ile Leu Lys Ile Cys His
             100                 105                 110        
 Thr Leu Thr Glu Lys Leu Val Ala Met Thr Met Gly Ser Gly Ala Lys
         115                 120                 125            
 Met Lys Thr Ser Ala Ser Val Ser Asp Ile Ile Val Val Ala Lys Arg
     130                 135                 140                
 Ile Ser Pro Arg Val Asp Asp Val Val Lys Ser Met Tyr Pro Pro Leu
 145                 150                 155                 160
 Asp Pro Lys Leu Leu Asp Ala Arg Thr Thr Ala Leu Leu Leu Ser Val
                 165                 170                 175    
 Ser His Leu Val Leu Val Thr Arg Asn Ala Cys His Leu Thr Gly Gly
             180                 185                 190        
 Leu Asp Trp Ile Asp Gln Ser Leu Ser Ala Ala Glu Glu His Leu Glu
         195                 200                 205            
 Val Leu Arg Glu Ala Ala Leu Ala Ser Glu Pro Asp Lys Gly Leu Pro
     210                 215                 220                
 Gly Pro Glu Gly Phe Leu Gln Glu Gln Ser Ala Ile
 225                 230                 235    



      <210> 3025
      <211> 602
      <212> PRT
      <213> Homo sapiens


      <400> 3025
 Ser Ser Pro Arg Glu Lys Thr Ser Asp Ser Ser His Arg Pro Ser Arg
   1               5                  10                  15    
 His Gly Phe Leu Phe Leu Arg Leu Val Gly Leu Ser Pro Phe Ser Tyr
              20                  25                  30        
 Leu Cys Val Pro Pro Ser Arg Pro Val Pro Gly Ser Pro Arg Ser Leu
          35                  40                  45            
 Ser Ala Met Arg Leu Leu Pro Leu Ala Pro Gly Arg Leu Arg Arg Gly
      50                  55                  60                
 Ser Pro Arg His Leu Pro Ser Cys Ser Pro Ala Leu Leu Leu Leu Val
  65                  70                  75                  80
 Leu Gly Gly Cys Leu Gly Val Phe Gly Val Ala Ala Gly Thr Arg Arg
                  85                  90                  95    
 Pro Asn Val Val Leu Leu Leu Thr Asp Asp Gln Asp Glu Val Leu Gly
             100                 105                 110        
 Gly Met Thr Pro Leu Lys Lys Thr Lys Ala Leu Ile Gly Glu Met Gly
         115                 120                 125            
 Met Thr Phe Ser Ser Ala Tyr Val Pro Ser Ala Leu Cys Cys Pro Ser
     130                 135                 140                
 Arg Ala Ser Ile Leu Thr Gly Lys Tyr Pro His Asn His His Val Val
 145                 150                 155                 160
 Asn Asn Thr Leu Glu Gly Asn Cys Ser Ser Lys Ser Trp Gln Lys Ile
                 165                 170                 175    
 Gln Glu Pro Asn Thr Phe Pro Ala Ile Leu Arg Ser Met Cys Gly Tyr
             180                 185                 190        
 Gln Thr Phe Phe Ala Gly Lys Tyr Leu Asn Glu Tyr Gly Ala Pro Asp
         195                 200                 205            
 Ala Gly Gly Leu Glu His Val Pro Leu Gly Trp Ser Tyr Trp Tyr Ala
     210                 215                 220                
 Leu Glu Lys Asn Ser Lys Tyr Tyr Asn Tyr Thr Leu Ser Ile Asn Gly
 225                 230                 235                 240
 Lys Ala Arg Lys His Gly Glu Asn Tyr Ser Val Asp Tyr Leu Thr Asp
                 245                 250                 255    
 Val Leu Ala Asn Val Ser Leu Asp Phe Leu Asp Tyr Lys Ser Asn Phe
             260                 265                 270        
 Glu Pro Phe Phe Met Met Thr Ala Thr Pro Ala Pro His Ser Pro Trp
         275                 280                 285            
 Thr Ala Ala Pro Gln Tyr Gln Lys Ala Phe Gln Asn Val Phe Ala Pro
     290                 295                 300                
 Arg Asn Lys Asn Phe Asn Ile His Gly Thr Asn Lys His Trp Leu Ile
 305                 310                 315                 320
 Arg Gln Ala Lys Thr Pro Met Thr Asn Ser Ser Ile Gln Phe Leu Asp
                 325                 330                 335    
 Asn Ala Phe Arg Lys Arg Trp Gln Thr Leu Leu Ser Val Asp Asp Leu
             340                 345                 350        
 Val Glu Lys Leu Val Lys Arg Leu Glu Phe Thr Gly Glu Leu Asn Asn
         355                 360                 365            
 Thr Tyr Ile Phe Tyr Thr Ser Asp Asn Gly Tyr His Thr Gly Gln Phe
     370                 375                 380                
 Ser Leu Pro Ile Asp Lys Arg Gln Leu Tyr Glu Phe Asp Ile Lys Val
 385                 390                 395                 400
 Pro Leu Leu Val Arg Gly Pro Gly Ile Lys Pro Asn Gln Thr Ser Lys
                 405                 410                 415    
 Met Leu Val Ala Asn Ile Asp Leu Gly Pro Thr Ile Leu Asp Ile Ala
             420                 425                 430        
 Gly Tyr Asp Leu Asn Lys Thr Gln Met Asp Gly Met Ser Leu Leu Pro
         435                 440                 445            
 Ile Leu Arg Gly Ala Ser Asn Leu Thr Trp Arg Ser Asp Val Leu Val
     450                 455                 460                
 Glu Tyr Gln Gly Glu Gly Arg Asn Val Thr Asp Pro Thr Cys Pro Ser
 465                 470                 475                 480
 Leu Ser Pro Gly Val Ser Gln Cys Phe Pro Asp Cys Val Cys Glu Asp
                 485                 490                 495    
 Ala Tyr Asn Asn Thr Tyr Ala Cys Val Arg Thr Met Ser Ala Leu Trp
             500                 505                 510        
 Asn Leu Gln Tyr Cys Glu Phe Asp Asp Gln Glu Val Phe Val Glu Val
         515                 520                 525            
 Tyr Asn Leu Thr Ala Asp Pro Asp Gln Ile Thr Asn Ile Ala Lys Thr
     530                 535                 540                
 Ile Asp Pro Glu Leu Leu Gly Lys Met Asn Tyr Arg Leu Met Met Leu
 545                 550                 555                 560
 Gln Ser Cys Ser Gly Pro Thr Cys Arg Thr Pro Gly Val Phe Asp Pro
                 565                 570                 575    
 Gly Tyr Arg Phe Asp Pro Arg Leu Met Phe Ser Asn Arg Gly Ser Val
             580                 585                 590        
 Arg Thr Arg Arg Phe Ser Lys His Leu Leu
         595                 600        



      <210> 3026
      <211> 117
      <212> PRT
      <213> Homo sapiens


      <400> 3026
 Ser Gly Gly Ala Val Gly Thr Ala Arg Ser Pro Ala Leu Gly Met Ala
   1               5                  10                  15    
 Leu Leu Val Leu Gly Leu Val Ser Cys Thr Phe Phe Leu Ala Val Asn
              20                  25                  30        
 Gly Leu Tyr Ser Ser Ser Asp Asp Val Ile Glu Leu Thr Pro Ser Asn
          35                  40                  45            
 Phe Asn Arg Glu Val Ile Gln Ser Glu Ser His Asn Arg Gly Phe Arg
      50                  55                  60                
 Pro Phe Ser Phe Leu Gly Ser Gln Trp Ile Phe Pro Ala Val Lys Gly
  65                  70                  75                  80
 His Ser Leu His Ser Asp Asp Ser Thr Ser Gly Pro Phe Asn Gln Glu
                  85                  90                  95    
 Val Val Leu Asp Trp Ser Phe Glu Asn Thr Ala Thr Val Asn Phe Cys
             100                 105                 110        
 Ile Ser Arg Lys His
         115        



      <210> 3027
      <211> 1355
      <212> PRT
      <213> Homo sapiens

      <220>
      <221> misc_feature
      <222> (1)...(1355)
      <223> Xaa = any amino acid or symbol as shown in the table 8 as set forth in Example 2


      <400> 3027
 Ala Pro Pro Ala Gly Arg Arg Arg Met Gln Ala Ala Pro Arg Ala Gly
   1               5                  10                  15    
 Cys Gly Ala Ala Leu Leu Leu Trp Ile Val Ser Ser Cys Leu Cys Arg
              20                  25                  30        
 Ala Trp Thr Ala Pro Ser Thr Ser Gln Lys Cys Asp Glu Pro Leu Val
          35                  40                  45            
 Ser Gly Leu Pro His Val Ala Phe Ser Ser Ser Ser Ser Ile Ser Gly
      50                  55                  60                
 Ser Tyr Ser Pro Gly Tyr Ala Lys Ile Asn Lys Arg Gly Gly Ala Gly
  65                  70                  75                  80
 Gly Trp Ser Pro Ser Asp Ser Asp His Tyr Gln Trp Leu Gln Val Asp
                  85                  90                  95    
 Phe Gly Asn Arg Lys Gln Ile Ser Ala Ile Ala Thr Gln Gly Arg Tyr
             100                 105                 110        
 Ser Ser Ser Asp Trp Val Thr Gln Tyr Arg Met Leu Tyr Ser Asp Thr
         115                 120                 125            
 Gly Arg Asn Trp Lys Pro Tyr His Gln Asp Gly Asn Ile Trp Ala Phe
     130                 135                 140                
 Pro Gly Asn Ile Asn Ser Asp Gly Val Val Arg His Glu Leu Gln His
 145                 150                 155                 160
 Pro Ile Ile Ala Arg Tyr Val Arg Ile Val Pro Leu Asp Trp Asn Gly
                 165                 170                 175    
 Glu Gly Arg Ile Gly Leu Arg Ile Glu Val Tyr Gly Cys Ser Tyr Trp
             180                 185                 190        
 Ala Asp Val Ile Asn Phe Asp Gly His Val Val Leu Pro Tyr Arg Phe
         195                 200                 205            
 Arg Asn Lys Lys Met Lys Thr Leu Lys Asp Val Ile Ala Leu Asn Phe
     210                 215                 220                
 Lys Thr Ser Glu Ser Glu Gly Val Ile Leu His Gly Glu Gly Gln Gln
 225                 230                 235                 240
 Gly Asp Tyr Ile Thr Leu Glu Leu Lys Lys Ala Lys Leu Val Leu Ser
                 245                 250                 255    
 Leu Asn Leu Gly Ser Asn Gln Leu Gly Pro Ile Tyr Gly His Thr Ser
             260                 265                 270        
 Val Met Thr Gly Ser Leu Leu Asp Asp His His Trp His Ser Val Val
         275                 280                 285            
 Ile Glu Arg Gln Gly Arg Ser Ile Asn Leu Thr Leu Asp Arg Ser Met
     290                 295                 300                
 Gln His Phe Arg Thr Asn Gly Glu Phe Asp Tyr Leu Asp Leu Asp Tyr
 305                 310                 315                 320
 Glu Ile Thr Phe Gly Gly Ile Pro Phe Ser Gly Lys Pro Ser Ser Ser
                 325                 330                 335    
 Ser Arg Lys Asn Phe Lys Gly Cys Met Glu Ser Ile Asn Tyr Asn Gly
             340                 345                 350        
 Val Asn Ile Thr Asp Leu Ala Arg Arg Lys Lys Leu Glu Pro Ser Asn
         355                 360                 365            
 Val Gly Asn Leu Ser Phe Ser Cys Val Glu Pro Tyr Thr Val Pro Val
     370                 375                 380                
 Phe Phe Asn Ala Thr Ser Tyr Leu Glu Val Pro Gly Arg Leu Asn Gln
 385                 390                 395                 400
 Asp Leu Phe Ser Val Ser Phe Gln Phe Arg Thr Trp Asn Pro Asn Gly
                 405                 410                 415    
 Leu Leu Val Phe Ser His Phe Ala Asp Asn Leu Gly Asn Val Glu Ile
             420                 425                 430        
 Asp Leu Thr Glu Ser Lys Val Gly Val His Ile Asn Ile Thr Gln Thr
         435                 440                 445            
 Lys Met Ser Gln Ile Asp Ile Ser Ser Gly Ser Gly Leu Asn Asp Gly
     450                 455                 460                
 Gln Trp His Glu Val Arg Phe Leu Ala Lys Glu Asn Phe Ala Ile Leu
 465                 470                 475                 480
 Thr Ile Asp Gly Asp Glu Ala Ser Ala Val Arg Thr Asn Ser Pro Leu
                 485                 490                 495    
 Gln Val Lys Thr Gly Glu Lys Tyr Phe Phe Gly Gly Phe Leu Asn Gln
             500                 505                 510        
 Met Asn Asn Ser Ser His Ser Val Leu Gln Pro Ser Phe Gln Gly Cys
         515                 520                 525            
 Met Gln Leu Ile Gln Val Asp Asp Gln Leu Val Asn Leu Tyr Glu Val
     530                 535                 540                
 Ala Gln Arg Lys Pro Gly Ser Phe Ala Asn Val Ser Ile Asp Met Cys
 545                 550                 555                 560
 Ala Ile Ile Asp Arg Cys Val Pro Asn His Cys Glu His Gly Gly Lys
                 565                 570                 575    
 Cys Ser Gln Thr Trp Asp Ser Phe Lys Cys Thr Cys Asp Glu Thr Gly
             580                 585                 590        
 Tyr Ser Gly Ala Thr Cys His Asn Ser Ile Tyr Glu Pro Ser Cys Glu
         595                 600                 605            
 Ala Tyr Lys His Leu Gly Gln Thr Ser Asn Tyr Tyr Trp Ile Asp Pro
     610                 615                 620                
 Asp Gly Ser Gly Pro Leu Gly Pro Leu Lys Val Tyr Cys Asn Met Thr
 625                 630                 635                 640
 Glu Asp Lys Val Trp Thr Ile Val Ser His Asp Leu Gln Met Gln Thr
                 645                 650                 655    
 Pro Val Val Gly Tyr Asn Pro Glu Lys Tyr Ser Val Thr Gln Leu Val
             660                 665                 670        
 Tyr Ser Ala Ser Met Asp Gln Ile Ser Ala Ile Thr Asp Ser Ala Glu
         675                 680                 685            
 Tyr Cys Glu Gln Tyr Val Ser Tyr Phe Cys Lys Met Ser Arg Leu Leu
     690                 695                 700                
 Asn Thr Pro Asp Gly Ser Pro Tyr Thr Trp Trp Val Gly Lys Ala Asn
 705                 710                 715                 720
 Glu Lys His Tyr Tyr Trp Gly Gly Ser Gly Pro Gly Ile Gln Lys Cys
                 725                 730                 735    
 Ala Cys Gly Ile Glu Arg Asn Cys Thr Asp Pro Lys Tyr Tyr Cys Asn
             740                 745                 750        
 Cys Asp Ala Asp Tyr Lys Gln Trp Arg Lys Asp Ala Gly Phe Leu Ser
         755                 760                 765            
 Tyr Lys Asp His Leu Pro Val Ser Gln Val Val Val Gly Asp Thr Asp
     770                 775                 780                
 Arg Gln Gly Ser Glu Ala Lys Leu Ser Val Gly Pro Leu Arg Cys Gln
 785                 790                 795                 800
 Gly Asp Arg Asn Tyr Trp Asn Ala Ala Ser Phe Pro Asn Pro Ser Ser
                 805                 810                 815    
 Tyr Leu His Phe Ser Thr Phe Gln Gly Glu Thr Ser Ala Asp Ile Ser
             820                 825                 830        
 Phe Tyr Phe Lys Thr Leu Thr Pro Trp Gly Val Phe Leu Glu Asn Met
         835                 840                 845            
 Gly Lys Glu Asp Phe Ile Lys Leu Glu Leu Lys Ser Ala Thr Glu Val
     850                 855                 860                
 Ser Phe Ser Phe Asp Val Gly Asn Gly Pro Val Glu Ile Val Val Arg
 865                 870                 875                 880
 Ser Pro Thr Pro Leu Asn Asp Asp Gln Trp His Arg Val Thr Ala Glu
                 885                 890                 895    
 Arg Asn Val Lys Gln Ala Ser Leu Gln Val Asp Arg Leu Pro Gln Gln
             900                 905                 910        
 Ile Arg Lys Ala Pro Thr Glu Gly His Thr Arg Leu Glu Leu Tyr Ser
         915                 920                 925            
 Gln Leu Phe Val Gly Gly Ala Gly Gly Gln Gln Gly Phe Leu Gly Cys
     930                 935                 940                
 Ile Arg Ser Leu Arg Met Asn Gly Val Thr Leu Asp Leu Glu Glu Arg
 945                 950                 955                 960
 Ala Lys Val Thr Ser Gly Phe Ile Ser Gly Cys Ser Gly His Cys Thr
                 965                 970                 975    
 Ser Tyr Gly Thr Asn Cys Glu Asn Gly Gly Lys Cys Leu Glu Arg Tyr
             980                 985                 990        
 His Gly Tyr Ser Cys Asp Cys Ser Asn Thr Ala Tyr Asp Gly Thr Phe
         995                1000                1005            
 Cys Asn Lys Asp Val Gly Ala Phe Phe Glu Glu Gly Met Trp Leu Arg
    1010                1015                1020                
 Tyr Asn Phe Gln Ala Pro Ala Thr Asn Ala Arg Asp Ser Ser Ser Arg
1025                1030                1035                1040
 Val Asp Asn Ala Pro Asp Gln Gln Asn Ser His Pro Asp Leu Ala Gln
                1045                1050                1055    
 Glu Glu Ile Arg Phe Ser Phe Ser Thr Thr Lys Ala Pro Cys Ile Leu
            1060                1065                1070        
 Leu Tyr Ile Ser Ser Phe Thr Thr Asp Phe Leu Ala Val Leu Val Lys
        1075                1080                1085            
 Pro Thr Gly Ser Leu Gln Ile Arg Tyr Asn Leu Gly Gly Thr Arg Glu
    1090                1095                1100                
 Pro Tyr Asn Ile Asp Val Asp His Arg Asn Met Ala Asn Gly Gln Pro
1105                1110                1115                1120
 His Ser Val Asn Ile Thr Arg His Glu Lys Thr Ile Phe Leu Lys Leu
                1125                1130                1135    
 Asp His Tyr Pro Ser Val Ser Tyr His Leu Pro Ser Ser Ser Asp Thr
            1140                1145                1150        
 Leu Phe Asn Ser Pro Lys Ser Leu Phe Leu Gly Lys Val Ile Glu Thr
        1155                1160                1165            
 Gly Lys Ile Asp Gln Glu Ile His Lys Tyr Asn Thr Pro Gly Phe Thr
    1170                1175                1180                
 Gly Cys Leu Ser Arg Val Gln Phe Asn Gln Ile Ala Pro Leu Lys Ala
1185                1190                1195                1200
 Ala Leu Arg Gln Thr Asn Ala Ser Ala His Val His Ile Gln Gly Glu
                1205                1210                1215    
 Leu Val Glu Ser Asn Cys Gly Ala Ser Pro Leu Thr Leu Ser Pro Met
            1220                1225                1230        
 Ser Ser Ala Thr Asp Pro Trp His Leu Asp His Leu Asp Ser Ala Ser
        1235                1240                1245            
 Ala Asp Phe Pro Tyr Asn Pro Gly Gln Gly Gln Ala Ile Arg Asn Gly
    1250                1255                1260                
 Val Asn Arg Asn Ser Ala Ile Ile Gly Gly Val Ile Ala Val Val Ile
1265                1270                1275                1280
 Phe Thr Pro Ser Leu Cys Thr Pro Val Leu Pro Xaa Ser Arg Xaa His
                1285                1290                1295    
 Val Ser Pro His Lys Gly Thr Leu Pro Ile Pro Asn Glu Ala Lys Gly
            1300                1305                1310        
 Ala Gly Ser Arg Gln Lys Lys Pro Gly Arg Arg Pro Ser Met Asn Asn
        1315                1320                1325            
 Asp Pro Pro Thr Ser Gln Arg Pro Ile Asp Glu Ser Lys Lys Glu Trp
    1330                1335                1340                
 Pro His Leu Arg Gly Gly Tyr Leu Ala Met Gly
1345                1350                1355



      <210> 3028
      <211> 437
      <212> PRT
      <213> Homo sapiens

      <220>
      <221> misc_feature
      <222> (1)...(437)
      <223> Xaa = any amino acid or symbol as shown in the table 8 as set forth in Example 2


      <400> 3028
 Val Ser Gln Ala Thr Asp Val Glu Val Gly Thr Asp Leu Val Pro Ser
   1               5                  10                  15    
 Val Thr Val Lys Val Thr Leu Gln Asn Arg Val Ile Leu Gln Lys Ala
              20                  25                  30        
 Lys Leu Ser Val Tyr Val Gln Pro Pro Leu Glu Leu Thr Cys Asp Gln
          35                  40                  45            
 Phe Thr Phe Glu Phe Met Asn Arg Asn Pro Asp Gly Ile Pro Arg Val
      50                  55                  60                
 Ile Gln Cys Lys Phe Arg Leu Pro Leu Lys Leu Ile Cys Leu Pro Gly
  65                  70                  75                  80
 Gln Pro Ser Lys Thr Ala Ser His Lys Ile Thr Ile Asp Thr Asn Lys
                  85                  90                  95    
 Ser Pro Val Ser Leu Leu Ser Leu Phe Pro Gly Phe Ala Ser Gln Ser
             100                 105                 110        
 Asp Asp Asp Gln Val Asn Val Met Gly Phe His Phe Leu Gly Gly Ala
         115                 120                 125            
 Arg Ile Thr Val Leu Ala Ser Lys Thr Ser Ser Thr Asp Ile Arg Ile
     130                 135                 140                
 Pro Gly Val Glu Gln Phe Glu Asp Leu Trp Ala Ser Leu Thr Asn Glu
 145                 150                 155                 160
 Leu Ile Leu Arg Leu Gln Glu Tyr Phe Glu Lys Gln Gly Val Lys Asp
                 165                 170                 175    
 Phe Ala Cys Ser Phe Ser Gly Ser Ile Thr Pro Phe Lys Glu Tyr Phe
             180                 185                 190        
 Glu Leu Ile Gly Ser Ile His Phe Glu Leu Arg Ile Asn Gly Glu Lys
         195                 200                 205            
 Leu Glu Glu Leu Leu Ser Glu Arg Ala Val Gln Phe Arg Ala Ile Gln
     210                 215                 220                
 Arg Arg Leu Leu Ala Arg Phe Lys Asp Lys Thr Pro Ala Pro Leu Gln
 225                 230                 235                 240
 His Leu Gly His Leu Val Arg Met Gly Thr Tyr Lys Gln Val Ile Ala
                 245                 250                 255    
 Leu Ala Asp Ala Val Gly Gly Lys Thr Lys Gly Asn Leu Phe Gln Ser
             260                 265                 270        
 Phe Thr Arg Leu Lys Ser Ala Thr His Leu Val Ile Leu Leu Ile Ala
         275                 280                 285            
 Leu Trp Gln Lys Leu Ser Ala Asp Gln Val Ala Ile Leu Glu Ala Ala
     290                 295                 300                
 Phe Leu Pro Leu Gln Glu Asp Thr Gln Glu Leu Gly Trp Glu Glu Thr
 305                 310                 315                 320
 Val Asp Ala Ala Ile Phe His Leu Xaa Lys Thr Cys Cys Arg Lys Ser
                 325                 330                 335    
 Ala Lys Gln Gln Ala Leu Asn Pro Pro Gly Arg Leu Thr Tyr Pro Asn
             340                 345                 350        
 Asp Thr Ser Gln Leu Lys Lys His Ile Thr Leu Leu Cys Asp Arg Leu
         355                 360                 365            
 Ser Lys Gly Gly Arg Leu Cys Leu Ser Thr Asp Ala Ala Ala Pro His
     370                 375                 380                
 Gln Thr Met Val Met Pro Gly Gly Cys Thr Thr Ile Pro Glu Ser Asp
 385                 390                 395                 400
 Leu Glu Glu Arg Ser Val Glu Gln Asp Ser Thr Glu Leu Phe Thr Asn
                 405                 410                 415    
 His Arg His Leu Thr Ala Glu Thr Pro Arg Pro Glu Val Ser Pro Leu
             420                 425                 430        
 Gln Gly Val Ser Glu
         435        



      <210> 3029
      <211> 94
      <212> PRT
      <213> Homo sapiens


      <400> 3029
 Val Gly Phe Ser Leu Leu Arg Cys Leu Trp Leu Gly Ser Arg Pro Gly
   1               5                  10                  15    
 Val Gly Gly His Gln Asp Lys Ser Val Gly Leu Gly Arg Ala Ala Thr
              20                  25                  30        
 Trp Ser Leu Glu Gly Ala Val Ser Ser Met Leu Gln Gly His Ser Ser
          35                  40                  45            
 Val Phe Gln Ala Leu Leu Gly Thr Phe Phe Thr Trp Gly Met Thr Ala
      50                  55                  60                
 Ala Gly Ala Ala Leu Val Phe Val Phe Ser Ser Gly Gln Arg Arg Ile
  65                  70                  75                  80
 Leu Asp Gly Ser Leu Gly Phe Ala Ala Gly Val Ser Ser Met
                  85                  90                



      <210> 3030
      <211> 357
      <212> PRT
      <213> Homo sapiens


      <400> 3030
 Leu Thr Arg Leu Met Glu His Ile Ser Ile Ile Pro Asp Tyr Arg Gln
   1               5                  10                  15    
 Ala Trp Lys Val Glu His Lys Leu Ser Asp Ile Leu Leu Leu Thr Ile
              20                  25                  30        
 Cys Ala Val Ile Ser Gly Ala Glu Gly Trp Glu Asp Ile Glu Asp Phe
          35                  40                  45            
 Gly Glu Thr His Pro Asp Phe Leu Lys Gln Tyr Gly Asp Phe Glu Asn
      50                  55                  60                
 Gly Ile Pro Val His Asp Thr Ile Ala Arg Val Val Ser Cys Ile Cys
  65                  70                  75                  80
 Pro Ala Lys Phe His Glu Ser Phe Ile Asn Trp Met Leu Asp Tyr His
                  85                  90                  95    
 Ser Ser Asp Asp Lys Asp Val Ile Ala Ile Asp Gly Lys Ile His Arg
             100                 105                 110        
 His Ser Tyr Asp Lys Ser Arg Arg Lys Gly Ala Ile His Val Ile Ser
         115                 120                 125            
 Ala Phe Ser Thr Met His Ser Leu Val Ile Gly Gln Ile Lys Thr Ser
     130                 135                 140                
 Ala Pro Gly Gln Ser Gly Gly Gly Gly Val His Arg Gly Thr Ile Val
 145                 150                 155                 160
 Val Gly Ser Asn Leu Leu Val Arg Arg Glu Leu Arg Ser Cys Met Thr
                 165                 170                 175    
 Ser Thr Arg Val Thr Ser Thr Arg Val Lys Ser Ala His Thr Arg Asp
             180                 185                 190        
 Ile His Thr Arg Asp Thr His Met Arg Asp Thr Ser Thr His Val Thr
         195                 200                 205            
 Ser Thr His Met Thr Ser Ala His Thr Cys Asp Ile His Thr Arg Asp
     210                 215                 220                
 Ile Ser Thr Arg Val Pro Phe Thr His Val Thr Leu Ala Lys Val Leu
 225                 230                 235                 240
 Thr Gln Ser Gln Pro Val Thr Val Val Tyr Ala Phe Lys Ser Asn Asn
                 245                 250                 255    
 Phe Ala Arg Trp Arg Gln Arg Ile Pro Lys Arg Ile Ala Phe Val Cys
             260                 265                 270        
 Asp Ala Gly Met Gly Ser Ser Ala Met Gly Ala Thr Thr Phe Arg Lys
         275                 280                 285            
 Arg Leu Glu Lys Ala Gly Leu Ala Ile Glu Val Lys His Tyr Ala Ile
     290                 295                 300                
 Glu Asn Val Pro Ala Asp Ala Asp Ile Val Val Thr His Ala Ser Leu
 305                 310                 315                 320
 Glu Gly Arg Val Lys Arg Val Thr Asp Lys Pro Leu Ile Leu Ile Asn
                 325                 330                 335    
 Asn Tyr Ile Gly Asp Pro Lys Leu Asp Thr Leu Phe Asn Gln Leu Thr
             340                 345                 350        
 Ala Glu His Lys His
         355        



      <210> 3031
      <211> 139
      <212> PRT
      <213> Homo sapiens


      <400> 3031
 Asn Asp Phe Val Gln Pro Pro Leu Ser Ala Ala Glu Val Gly Ile Cys
   1               5                  10                  15    
 Cys Val Pro Gly Gln Val Pro Gly Gln Ser Val Leu Gly Met Ala Ala
              20                  25                  30        
 Ile Asn Pro Trp Ala Ser Trp Gly Ala Leu Thr Asp Gln Ser Trp Gly
          35                  40                  45            
 Met Thr Ala Val Asp Pro Trp Ala Ser Trp Ala Leu Cys Pro Gln Tyr
      50                  55                  60                
 Pro Ala Trp His Val Glu Gly Ser Leu Glu Glu Gly Arg Arg Ala Thr
  65                  70                  75                  80
 Gly Leu Pro Ala Ala Gln Val Gln Glu Pro Val Thr Phe Lys Asp Val
                  85                  90                  95    
 Ala Val Asp Phe Thr Gln Glu Glu Trp Gly Gln Leu Asp Leu Val Gln
             100                 105                 110        
 Arg Thr Leu His Arg Asp Val Met Leu Glu Thr Tyr Gly His Leu Leu
         115                 120                 125            
 Ser Val Gly Asn Gln Ile Ala Lys Pro Glu Val
     130                 135                



      <210> 3032
      <211> 193
      <212> PRT
      <213> Homo sapiens


      <400> 3032
 Gln Arg Phe Lys Asn Asp Cys Arg Asp Pro Arg Asp Thr Gly Pro Ile
   1               5                  10                  15    
 His Gly Leu Trp Pro Asp Lys Ser Glu Gly Cys Asn Arg Ser Trp Pro
              20                  25                  30        
 Phe Asn Leu Glu Glu Ile Lys Asp Leu Cys Pro Glu Met Arg Ala Tyr
          35                  40                  45            
 Trp Pro Asp Val Ile His Ser Phe Pro Asn Arg Ser Arg Phe Trp Lys
      50                  55                  60                
 His Glu Trp Glu Lys His Gly Thr Cys Ala Ala Gln Val Asp Ala Leu
  65                  70                  75                  80
 Asn Ser Gln Lys Lys Tyr Phe Gly Arg Ser Leu Glu Leu Tyr Arg Glu
                  85                  90                  95    
 Leu Asp Leu Asn Gln Val Ala Asp Phe Lys Asp Ala Leu Ala Arg Val
             100                 105                 110        
 Tyr Gly Val Ile Pro Lys Ile Gln Cys Leu Pro Pro Ser Gln Asp Glu
         115                 120                 125            
 Glu Val Gln Thr Ile Gly Gln Ile Glu Leu Cys Leu Thr Lys Gln Asp
     130                 135                 140                
 Gln Gln Leu Gln Asn Cys Thr Glu Pro Gly Glu Gln Pro Ser Pro Lys
 145                 150                 155                 160
 Gln Glu Val Trp Leu Ala Asn Gly Ala Ala Glu Ser Arg Gly Leu Arg
                 165                 170                 175    
 Val Cys Glu Asp Gly Pro Val Phe Tyr Pro Pro Pro Lys Lys Thr Lys
             180                 185                 190        
 His
    



      <210> 3033
      <211> 120
      <212> PRT
      <213> Homo sapiens

      <220>
      <221> misc_feature
      <222> (1)...(120)
      <223> Xaa = any amino acid or symbol as shown in the table 8 as set forth in Example 2


      <400> 3033
 Met Ala Leu Thr Gly Tyr Ser Trp Leu Leu Leu Ser Ala Thr Phe Leu
   1               5                  10                  15    
 Asn Val Gly Ala Glu Ile Ser Ile Thr Leu Glu Pro Ala Gln Pro Ser
              20                  25                  30        
 Glu Gly Asp Asn Val Thr Leu Val Val His Gly Leu Ser Gly Glu Leu
          35                  40                  45            
 Leu Ala Tyr Ser Trp Tyr Ala Gly Pro Thr Leu Ser Val Ser Tyr Leu
      50                  55                  60                
 Val Ala Ser Tyr Ile Val Ser Thr Gly Asp Glu Thr Pro Gly Pro Ala
  65                  70                  75                  80
 His Thr Xaa Arg Glu Ala Val Arg Pro Asp Gly Ser Leu Asp Ile Gln
                  85                  90                  95    
 Gly Ile Leu Pro Arg His Ser Ser Thr Tyr Ile Leu Gln Thr Phe Asn
             100                 105                 110        
 Arg Gln Leu Gln Thr Glu Val Gly
         115                 120



      <210> 3034
      <211> 190
      <212> PRT
      <213> Homo sapiens

      <220>
      <221> misc_feature
      <222> (1)...(190)
      <223> Xaa = any amino acid or symbol as shown in the table 8 as set forth in Example 2


      <400> 3034
 Thr Arg Asp Leu His Phe Ser Cys Pro His Leu Cys Phe Leu Thr Leu
   1               5                  10                  15    
 Gly Val Leu Arg Glu Ile Arg Val Pro Asp Leu Ser Pro Ile Asn Cys
              20                  25                  30        
 Gly Arg Thr Phe Xaa Lys Ala Xaa Val Arg Ala His Ser Trp Arg Leu
          35                  40                  45            
 Leu Gln Ser Cys Arg Ser Ser Leu Ala Glu Leu Met Ala Arg Thr Ser
      50                  55                  60                
 Leu Asp Leu Glu Leu Asp Leu Gln Ala Ser Arg Thr Arg Gln Arg Gln
  65                  70                  75                  80
 Leu Asn Glu Glu Leu Cys Ala Leu Arg Glu Leu Arg Gln Arg Leu Glu
                  85                  90                  95    
 Asp Ala Gln Leu Arg Gly Gln Thr Asp Leu Pro Pro Trp Val Leu Arg
             100                 105                 110        
 Asp Glu Arg Leu Arg Gly Leu Leu Arg Glu Ala Glu Arg Gln Thr Arg
         115                 120                 125            
 Gln Thr Lys Leu Asp Tyr Arg His Glu Gln Ala Ala Glu Lys Met Leu
     130                 135                 140                
 Lys Lys Ala Ser Lys Glu Ile Tyr Gln Leu Arg Gly Gln Ser His Lys
 145                 150                 155                 160
 Glu Pro Ile Gln Val Gln Thr Phe Arg Glu Lys Ile Ala Phe Phe Thr
                 165                 170                 175    
 Arg Pro Arg Ile Asn Ile Pro Pro Leu Pro Ala Asp Asp Val
             180                 185                 190



      <210> 3035
      <211> 1932
      <212> PRT
      <213> Homo sapiens


      <400> 3035
 Met Thr Pro Glu Ser Arg Asp Thr Thr Asp Leu Ser Pro Gly Gly Thr
   1               5                  10                  15    
 Gln Glu Met Glu Gly Ile Val Ile Val Lys Val Glu Glu Glu Asp Glu
              20                  25                  30        
 Glu Asp His Phe Gln Lys Glu Arg Asn Lys Val Glu Ser Ser Pro Gln
          35                  40                  45            
 Val Leu Ser Arg Ser Thr Thr Met Asn Glu Arg Ala Leu Leu Ser Ser
      50                  55                  60                
 Tyr Leu Val Ala Tyr Arg Val Ala Lys Glu Lys Met Ala His Thr Ala
  65                  70                  75                  80
 Ala Glu Lys Ile Ile Leu Pro Ala Cys Met Asp Met Val Arg Thr Ile
                  85                  90                  95    
 Phe Asp Asp Lys Ser Ala Asp Lys Leu Arg Thr Ile Pro Leu Ser Asp
             100                 105                 110        
 Asn Thr Ile Ser Arg Arg Ile Cys Thr Ile Ala Lys His Leu Glu Ala
         115                 120                 125            
 Met Leu Ile Thr Arg Leu Gln Ser Gly Ile Asp Phe Ala Ile Gln Leu
     130                 135                 140                
 Asp Glu Ser Thr Asp Ile Ala Ser Cys Pro Thr Leu Leu Val Tyr Val
 145                 150                 155                 160
 Arg Tyr Ile Pro Leu Lys Leu Arg Leu Gly Gly Leu Leu Gln Pro Glu
                 165                 170                 175    
 Lys Pro Ile Val Leu Lys Val Glu Ser Arg Asp Gly Thr Ile Gln Tyr
             180                 185                 190        
 Asn Ser Gln Gln His Ile Asn Leu Ser Ala Ala Trp Leu Lys Thr Ala
         195                 200                 205            
 Val Gln Gly Arg Glu Ala Pro Gly Lys Gln Pro Ser Lys Gln Gln His
     210                 215                 220                
 Ser Ala Lys Arg Lys Thr His Arg Thr Gln Leu Lys Lys Glu Ser Gly
 225                 230                 235                 240
 Asp Gly Pro His Pro Lys Phe Gly Gly Gly Asn Leu Ala Ser Pro Gly
                 245                 250                 255    
 Cys Gln Pro Gly Ala Pro Leu Ser Arg Tyr Phe Thr Tyr Arg Gly Ser
             260                 265                 270        
 Glu Leu Thr Ala Phe Trp Leu Thr Thr Leu Lys Lys Met Ser Val Pro
         275                 280                 285            
 Gly Thr Val Leu Leu Arg Tyr Gly Thr Arg Thr His Gly Leu Phe Lys
     290                 295                 300                
 Arg Leu Gly Ile Pro Gly Pro Thr Pro Leu Pro Leu Leu Gly Asn Val
 305                 310                 315                 320
 Leu Ser Tyr Arg Gln Lys Leu Val Lys Ile Glu Glu Val Ala Asp Val
                 325                 330                 335    
 Ala Val Ser Phe Ile Leu Glu Glu Trp Gly His Leu Asp Gln Ser Gln
             340                 345                 350        
 Lys Ser Leu Tyr Arg Asp Asp Arg Lys Glu Asn Tyr Gly Ser Ile Thr
         355                 360                 365            
 Ser Met Gly Tyr Glu Ser Arg Asp Asn Met Glu Leu Ile Val Lys Gln
     370                 375                 380                
 Ile Ser Asp Asp Ser Glu Ser His Trp Val Ala Pro Glu His Thr Glu
 385                 390                 395                 400
 Arg Ser Val Pro Gln Asp Pro Asp Phe Ala Glu Val Ser Asp Leu Lys
                 405                 410                 415    
 Gly Met Val Gln Arg Trp Gln Val Asn Pro Thr Val Gly Lys Ser Arg
             420                 425                 430        
 Gln Asn Pro Ser Gln Lys Arg Asp Leu Asp Ala Ile Thr Asp Ile Ser
         435                 440                 445            
 Pro Lys Gln Ser Thr His Gly Glu Arg Gly His Arg Cys Ser Asp Cys
     450                 455                 460                
 Gly Lys Phe Phe Leu Gln Ala Ser Asn Phe Ile Gln His Arg Arg Ile
 465                 470                 475                 480
 His Thr Gly Glu Lys Pro Phe Lys Cys Gly Glu Cys Gly Lys Ser Tyr
                 485                 490                 495    
 Asn Gln Arg Val His Leu Thr Gln His Gln Arg Val His Thr Gly Glu
             500                 505                 510        
 Lys Pro Tyr Lys Cys Gln Val Cys Gly Lys Ala Phe Arg Val Ser Ser
         515                 520                 525            
 His Leu Val Gln His His Ser Val His Ser Gly Glu Arg Pro Tyr Gly
     530                 535                 540                
 Cys Asn Glu Cys Gly Lys Asn Phe Gly Arg His Ser His Leu Ile Glu
 545                 550                 555                 560
 His Leu Lys Arg His Phe Arg Glu Lys Ser Gln Arg Cys Ser Asp Lys
                 565                 570                 575    
 Arg Ser Lys Asn Thr Lys Leu Ser Val Lys Lys Lys Ile Ser Glu Tyr
             580                 585                 590        
 Ser Glu Ala Asp Met Glu Leu Ser Gly Lys Thr Gln Arg Asn Val Ser
         595                 600                 605            
 Gln Val Gln Asp Phe Gly Glu Gly Cys Glu Phe Gln Gly Lys Leu Asp
     610                 615                 620                
 Arg Lys Gln Gly Ile Pro Met Lys Glu Ile Leu Gly Gln Pro Ser Ser
 625                 630                 635                 640
 Lys Arg Met Asn Tyr Ser Glu Val Pro Tyr Val His Lys Lys Ser Ser
                 645                 650                 655    
 Thr Gly Glu Arg Pro His Lys Cys Asn Glu Cys Gly Lys Ser Phe Ile
             660                 665                 670        
 Gln Ser Ala His Leu Ile Gln His Gln Arg Ile His Thr Gly Glu Lys
         675                 680                 685            
 Pro Phe Arg Cys Glu Glu Cys Gly Lys Ser Tyr Asn Gln Arg Val His
     690                 695                 700                
 Leu Thr Gln His Gln Arg Val His Thr Gly Glu Lys Pro Tyr Thr Cys
 705                 710                 715                 720
 Pro Leu Cys Gly Lys Ala Phe Arg Val Arg Ser His Leu Val Gln His
                 725                 730                 735    
 Gln Ser Val His Ser Gly Glu Arg Pro Phe Lys Cys Asn Glu Cys Gly
             740                 745                 750        
 Lys Gly Phe Gly Arg Arg Ser His Leu Ala Gly His Leu Arg Leu His
         755                 760                 765            
 Ser Arg Glu Lys Ser His Gln Cys Arg Glu Cys Gly Glu Ile Phe Phe
     770                 775                 780                
 Gln Tyr Val Ser Leu Ile Glu His Gln Val Leu His Met Gly Gln Lys
 785                 790                 795                 800
 Asn Glu Lys Asn Gly Ile Cys Glu Glu Ala Tyr Ser Trp Asn Leu Thr
                 805                 810                 815    
 Val Ile Glu Asp Lys Lys Ile Glu Leu Gln Glu Gln Pro Tyr Gln Cys
             820                 825                 830        
 Asp Ile Cys Gly Lys Ala Phe Gly Tyr Ser Ser Asp Leu Ile Gln His
         835                 840                 845            
 Tyr Arg Thr His Thr Ala Glu Lys Pro Tyr Gln Cys Asp Ile Cys Arg
     850                 855                 860                
 Glu Asn Val Gly Gln Cys Ser His Thr Lys Gln His Gln Lys Ile Tyr
 865                 870                 875                 880
 Ser Ser Thr Lys Ser His Gln Cys His Glu Cys Gly Arg Gly Phe Thr
                 885                 890                 895    
 Leu Lys Ser His Leu Asn Gln His Gln Arg Ile His Thr Asp Arg Asp
             900                 905                 910        
 Cys Gly Arg Gly Arg Gly Thr Ser Asn Gln Trp Arg Ser Val Lys Gly
         915                 920                 925            
 Arg Leu Gly Leu Phe Arg His Leu Pro Asp Arg Gly Gly Arg Ala Glu
     930                 935                 940                
 Asp Leu Glu Glu Lys Arg Pro Ala Pro Ser Thr Ser Leu Asn Ser Phe
 945                 950                 955                 960
 Leu Gln Leu Pro Val Lys Asp Ser Arg Pro Asp Phe Ile Gly Arg Asn
                 965                 970                 975    
 Cys Phe Gln Pro Gln Leu Glu Gly Leu Trp Lys Phe Asp Thr Glu Cys
             980                 985                 990        
 Tyr Lys Lys Tyr Gly Lys Met Trp Gly Thr Tyr Glu Gly Gln Leu Pro
         995                1000                1005            
 Val Leu Ala Ile Thr Asp Pro Asp Val Ile Arg Thr Val Leu Val Lys
    1010                1015                1020                
 Glu Cys Tyr Ser Val Phe Thr Asn Arg Arg Met Phe Pro Ile Ile Ala
1025                1030                1035                1040
 Gln Tyr Gly Asp Val Leu Val Arg Asn Leu Arg Arg Glu Ala Glu Lys
                1045                1050                1055    
 Gly Lys Pro Val Thr Leu Lys Asp Ile Phe Gly Ala Tyr Ser Met Asp
            1060                1065                1070        
 Val Ile Thr Gly Thr Ser Phe Gly Val Asn Ile Asp Ser Leu Asn Asn
        1075                1080                1085            
 Pro Gln Asp Pro Phe Val Glu Ser Thr Lys Lys Phe Leu Lys Phe Gly
    1090                1095                1100                
 Phe Leu Asp Pro Leu Phe Leu Ser Ile Ile Leu Phe Pro Phe Leu Thr
1105                1110                1115                1120
 Pro Val Phe Glu Ala Leu Asn Val Ser Leu Phe Pro Lys Asp Thr Ile
                1125                1130                1135    
 Asn Phe Leu Ser Lys Ser Val Asn Arg Met Lys Lys Ser Arg Leu Asn
            1140                1145                1150        
 Asp Lys Gln Lys Arg Pro Ala Glu Gly Cys Leu Gln Val Arg Glu Thr
        1155                1160                1165            
 Gly Pro Gly Asn Pro Ala Val Thr Glu Asp Tyr Ile Glu Phe Glu Asn
    1170                1175                1180                
 Val Gly Ile Phe Glu Asn Ala Pro Pro Lys Lys Leu Leu Met Ser Ser
1185                1190                1195                1200
 Gly Asn Val Arg Arg Leu Ile Tyr Thr Asp Thr Ala Glu Glu Lys Ala
                1205                1210                1215    
 Leu Ser Asp Leu Glu Leu Ala Ala Gln Ser Ile Ile Phe Ile Phe Ala
            1220                1225                1230        
 Gly Tyr Glu Thr Thr Ser Ser Val Leu Ser Phe Thr Leu Tyr Glu Leu
        1235                1240                1245            
 Ala Thr His Pro Asp Val Gln Gln Lys Leu Gln Lys Glu Ile Asp Ala
    1250                1255                1260                
 Val Leu Pro Asn Lys Glu Arg Ser Ser Ala Pro Ala Thr Glu Ser Trp
1265                1270                1275                1280
 Met Glu Asn Asp Phe Asp Glu Leu Arg Glu Glu Gly Phe Arg Arg Ser
                1285                1290                1295    
 Asn Tyr Ser Glu Leu Lys Glu Glu Val Arg Thr His Gly Lys Glu Val
            1300                1305                1310        
 Lys Asn Leu Glu Lys Arg Leu Asp Lys Trp Leu Thr Arg Ile Ile Asn
        1315                1320                1325            
 Ala Glu Lys Ser Leu Lys Asp Leu Met Glu Leu Lys Thr Met Ala Arg
    1330                1335                1340                
 Glu Leu Arg Asp Glu Cys Thr Ser Leu Ser Ser Gln Phe Asn Gln Leu
1345                1350                1355                1360
 Glu Glu Arg Val Ser Val Met Glu Asp Gln Met Asn Glu Met Lys Lys
                1365                1370                1375    
 Glu Glu Lys Phe Arg Arg Lys Arg Ile Lys Arg Lys Glu Gln Ser Leu
            1380                1385                1390        
 Gln Glu Ile Trp Asp Tyr Val Lys Arg Pro Asn Leu Arg Leu Ile Gly
        1395                1400                1405            
 Val Pro Glu Ser Asp Gly Glu Asn Arg Thr Lys Leu Glu Asn Thr Leu
    1410                1415                1420                
 Gln Asp Ile Ile Gln Glu Asn Phe Pro Asn Leu Ala Arg Gln Ala Asn
1425                1430                1435                1440
 Ile Gln Ile Gln Glu Ile Gln Arg Thr Pro Gln Arg Tyr Ser Ser Arg
                1445                1450                1455    
 Arg Ala Thr Pro Arg His Ile Ile Val Arg Phe Thr Lys Val Glu Met
            1460                1465                1470        
 Lys Glu Lys Met Leu Arg Ala Ala Arg Glu Lys Glu Ile Gln Thr Thr
        1475                1480                1485            
 Ile Arg Glu Tyr Tyr Lys His Leu Tyr Ala Asn Lys Leu Glu Asn Leu
    1490                1495                1500                
 Glu Glu Met Asp Lys Phe Leu Asp Thr Tyr Thr Leu Pro Arg Leu Asn
1505                1510                1515                1520
 Gln Glu Glu Val Glu Thr Leu Asn Arg Pro Ile Thr Gly Ser Glu Ile
                1525                1530                1535    
 Glu Ala Ile Ile Asn Ser Leu Pro Thr Lys Lys Ser Pro Gly Pro Asp
            1540                1545                1550        
 Gly Phe Thr Ala Glu Phe Tyr Gln Arg Tyr Lys Glu Asp Leu Val Pro
        1555                1560                1565            
 Phe Phe Leu Lys Leu Phe Gln Ser Ile Glu Lys Glu Gly Ile Leu Pro
    1570                1575                1580                
 Asn Ser Phe Tyr Glu Ala Ser Ile Ile Leu Ile Pro Lys Pro Gly Arg
1585                1590                1595                1600
 Asp Thr Thr Lys Lys Glu Asn Phe Arg Pro Ile Ser Leu Met Asn Ser
                1605                1610                1615    
 Asp Thr Lys Ile Leu Asn Lys Ile Leu Ala Asn Arg Ile Gln Gln His
            1620                1625                1630        
 Ile Lys Lys Leu Ile His His Asp Gln Val Gly Phe Ile Pro Gly Met
        1635                1640                1645            
 Gln Gly Trp Phe Asn Ile Arg Lys Ser Ile Asn Ile Ile Gln His Ile
    1650                1655                1660                
 Asn Arg Thr Asn Asp Lys Thr His Met Ile Ile Ser Ile Asp Ala Glu
1665                1670                1675                1680
 Lys Ala Phe Asn Lys Ile Gln Gln Pro Phe Met Leu Lys Thr Leu Asn
                1685                1690                1695    
 Lys Leu Val Leu Glu Val Leu Ala Arg Ala Ile Arg Gln Glu Lys Glu
            1700                1705                1710        
 Ile Lys Gly Ile Gln Leu Gly Lys Glu Glu Val Lys Leu Ser Leu Phe
        1715                1720                1725            
 Ala Asp Asp Met Ile Val Tyr Leu Glu Asn Pro Ile Val Ser Ala Gln
    1730                1735                1740                
 Asn Leu Leu Lys Leu Ile Asn Asn Phe Ser Lys Val Ser Gly Tyr Lys
1745                1750                1755                1760
 Ile Asn Val Gln Lys Ser Gln Ile Phe Leu Tyr Thr Asn Asn Arg Gln
                1765                1770                1775    
 Thr Glu Ser Gln Ile Met Ser Glu Leu Pro Phe Thr Ile Ala Ser Lys
            1780                1785                1790        
 Thr Ile Lys Tyr Leu Gly Ile Gln Leu Thr Arg Asp Val Lys Asp Leu
        1795                1800                1805            
 Phe Lys Glu Asn Tyr Lys Pro Leu Leu Asn Glu Ile Lys Glu Asp Thr
    1810                1815                1820                
 Asn Lys Trp Asn Asn Ile Pro Cys Ser Trp Val Gly Arg Ile Asn Ile
1825                1830                1835                1840
 Met Lys Met Ala Ile Leu Pro Lys Val Ile Tyr Arg Phe Ser Ala Ile
                1845                1850                1855    
 Ala Ile Lys Leu Pro Met Thr Phe Phe Thr Glu Leu Glu Lys Thr Thr
            1860                1865                1870        
 Leu Lys Phe Ile Trp Asn Gln Lys Arg Ala Arg Ile Ala Lys Ser Ile
        1875                1880                1885            
 Leu Ser Gln Lys Asn Lys Ala Gly Gly Ile Met Leu Pro Asp Phe Lys
    1890                1895                1900                
 Leu Tyr Tyr Lys Ala Thr Val Thr Lys Thr Ala Trp Tyr Trp Tyr Gln
1905                1910                1915                1920
 Asn Arg Asp Ile Asp Gln Trp Ser Arg Thr Glu Pro
                1925                1930        



      <210> 3036
      <211> 378
      <212> PRT
      <213> Homo sapiens


      <400> 3036
 Met Thr Gln Ile Ser Asn Ile Lys Gln Pro Phe Ala Met Gln His Arg
   1               5                  10                  15    
 Phe Phe Ile Ser Leu Leu His Trp Thr Leu Gln Ile Val Tyr Pro Ala
              20                  25                  30        
 Leu Phe Leu Gly Leu Cys Glu Arg Gly Arg Asn Gly Arg Cys Asp Gln
          35                  40                  45            
 Val Pro Glu Gly Ser Val Leu Ser Leu Leu Val Trp Val Val Pro Gly
      50                  55                  60                
 Leu Ala Phe Pro Glu Val Ala Pro Gly Thr Cys Gly Thr Ser Tyr Val
  65                  70                  75                  80
 Pro Asp Ala Gly Leu His Gly Pro Glu Val Glu Ser Lys Leu Gly Leu
                  85                  90                  95    
 Asp Pro Gly Ser Met Thr Gly Thr Gln Pro Thr Arg Thr Pro Ala Gln
             100                 105                 110        
 Pro Ala Ala Ala Glu Pro Pro Ala Leu Thr Gly Pro Gly Arg Val His
         115                 120                 125            
 Gln Glu Gln Ala Val Leu Ala Cys Gly Phe Leu Gly Ile Tyr His Leu
     130                 135                 140                
 Gly Ala Ala Ser Ala Leu Cys Arg His Gly Lys Lys Leu Val Lys Asp
 145                 150                 155                 160
 Val Lys Ala Phe Ala Gly Ala Ser Ala Gly Ser Leu Val Ala Ser Val
                 165                 170                 175    
 Leu Leu Thr Ala Pro Glu Lys Ile Glu Glu Cys Asn Gln Phe Thr Tyr
             180                 185                 190        
 Lys Phe Ala Glu Glu Ile Arg Arg Gln Ser Phe Gly Ala Val Thr Pro
         195                 200                 205            
 Gly Tyr Asp Phe Met Ala Arg Leu Arg Ser Gly Met Glu Ser Ile Leu
     210                 215                 220                
 Pro Pro Ser Ala His Glu Leu Ala Gln Asn Arg Leu His Val Ser Ile
 225                 230                 235                 240
 Thr Asn Ala Lys Thr Arg Glu Asn His Leu Val Ser Thr Phe Ser Ser
                 245                 250                 255    
 Arg Glu Asp Leu Ile Lys Val Leu Leu Ala Ser Ser Phe Val Pro Ile
             260                 265                 270        
 Tyr Ala Gly Leu Lys Leu Val Glu Tyr Lys Gly Gln Lys Trp Val Asp
         275                 280                 285            
 Gly Gly Leu Thr Asn Ala Leu Pro Ile Leu Pro Val Gly Arg Thr Val
     290                 295                 300                
 Thr Ile Ser Pro Phe Ser Gly Arg Leu Asp Ile Ser Pro Gln Asp Lys
 305                 310                 315                 320
 Gly Gln Leu Asp Leu Tyr Val Asn Ile Ala Lys Gln Asp Ile Met Leu
                 325                 330                 335    
 Ser Leu Ala Asn Leu Val Arg Leu Asn Gln Ala Leu Phe Pro Pro Ser
             340                 345                 350        
 Lys Arg Lys Met Glu Ser Leu Tyr Gln Cys Gly Phe Asp Asp Thr Val
         355                 360                 365            
 Lys Phe Leu Leu Lys Glu Asn Trp Phe Glu
     370                 375            



      <210> 3037
      <211> 341
      <212> PRT
      <213> Homo sapiens


      <400> 3037
 Ala Arg Arg Ser Pro Arg Ala Lys Ser Leu Phe Ser Phe Ser Ser Asn
   1               5                  10                  15    
 Lys Cys Leu Glu Leu Gln Glu Gly Pro Leu Cys Thr Met Ser Asn Gln
              20                  25                  30        
 Val Leu Cys Cys Val Val Leu Cys Phe Leu Gly Ala Asn Thr Val Asp
          35                  40                  45            
 Gly Gly Ile Thr Gln Ser Pro Lys Tyr Leu Phe Arg Lys Glu Gly Gln
      50                  55                  60                
 Asn Val Thr Leu Ser Cys Glu Gln Asn Leu Asn His Asp Ala Met Tyr
  65                  70                  75                  80
 Trp Tyr Arg Gln Asp Pro Gly Gln Gly Leu Arg Leu Ile Tyr Tyr Ser
                  85                  90                  95    
 Gln Ile Val Asn Asp Phe Gln Lys Gly Asp Ile Ala Glu Gly Tyr Ser
             100                 105                 110        
 Val Ser Arg Glu Lys Lys Glu Ser Phe Pro Leu Thr Val Thr Ser Ala
         115                 120                 125            
 Gln Lys Asn Pro Thr Ala Phe Tyr Leu Cys Ala Ser Ser Ile Gly Ala
     130                 135                 140                
 Gly Leu Pro Tyr Ser Asn Gln Pro Gln His Phe Gly Asp Gly Thr Arg
 145                 150                 155                 160
 Leu Ser Ile Leu Glu Asp Leu Asn Lys Val Phe Pro Pro Glu Val Ala
                 165                 170                 175    
 Val Phe Glu Pro Ser Glu Ala Glu Ile Ser His Thr Gln Lys Ala Thr
             180                 185                 190        
 Leu Val Cys Leu Ala Thr Gly Phe Phe Pro Asp His Val Glu Leu Ser
         195                 200                 205            
 Trp Trp Val Asn Gly Lys Glu Val His Ser Gly Val Ser Thr Asp Pro
     210                 215                 220                
 Gln Pro Leu Lys Glu Gln Pro Ala Leu Asn Asp Ser Arg Tyr Cys Leu
 225                 230                 235                 240
 Ser Ser Arg Leu Arg Val Ser Ala Thr Phe Trp Gln Asn Pro Arg Asn
                 245                 250                 255    
 His Phe Arg Cys Gln Val Gln Phe Tyr Gly Leu Ser Glu Asn Asp Glu
             260                 265                 270        
 Trp Thr Gln Asp Arg Ala Lys Pro Val Thr Gln Ile Val Ser Ala Glu
         275                 280                 285            
 Ala Trp Gly Arg Ala Asp Cys Gly Phe Thr Ser Val Ser Tyr Gln Gln
     290                 295                 300                
 Gly Val Leu Ser Ala Thr Ile Leu Tyr Glu Ile Leu Leu Gly Lys Ala
 305                 310                 315                 320
 Thr Leu Tyr Ala Val Leu Val Ser Ala Leu Val Leu Met Ala Met Val
                 325                 330                 335    
 Lys Arg Lys Asp Phe
             340    



      <210> 3038
      <211> 133
      <212> PRT
      <213> Homo sapiens


      <400> 3038
 Glu Ser Gly Asn Val Ser Gln Glu Ser Gly Pro Thr Tyr Ala Ser Phe
   1               5                  10                  15    
 Ser His His Phe Ile Ser Asp Ala Met Thr Gly Val Pro Thr Glu Asn
              20                  25                  30        
 Asp Asp Phe Cys Ile Leu Phe Ala Pro Lys Ala Ala Met Gln Glu Lys
          35                  40                  45            
 Glu Glu Glu Pro Val Ile Lys Ile Met Val Asp Asp Ala Ile Val Ile
      50                  55                  60                
 Arg Asp Asn Tyr Phe Ser Leu Pro Val Asn Lys Thr Asp Thr Ser Lys
  65                  70                  75                  80
 Ala Pro Leu His Phe Pro Ile Pro Val Ile Arg Tyr Val Val Lys Glu
                  85                  90                  95    
 Val Ser Leu Val Trp His Leu Tyr Gly Gly Lys Asp Phe Gly Thr Val
             100                 105                 110        
 Pro Pro Thr Ser Pro Ala Lys Ser Tyr Ile Ser Pro His Ser Ser Pro
         115                 120                 125            
 Ser His Thr Pro Thr
     130            



      <210> 3039
      <211> 136
      <212> PRT
      <213> Homo sapiens


      <400> 3039
 Arg Asp Lys Gln Thr Val Ala Tyr Arg Leu His Leu Gly Ala Arg Ala
   1               5                  10                  15    
 Leu Ala Tyr Gly Glu Lys Asn Leu Thr Phe Glu Gly Pro Leu Pro Glu
              20                  25                  30        
 Lys Ile Glu Leu Leu Ala His Lys Gly Leu Leu Asn Leu Thr Tyr Tyr
          35                  40                  45            
 Gln Gln Ile Gln Val Gln Lys Lys Asp Asn Lys Ile Phe Glu Ile Ser
      50                  55                  60                
 Cys Cys Ser Asp His Arg Cys Lys Trp Leu Pro Ala Ser Met Asn Thr
  65                  70                  75                  80
 Val Ser Thr Gln Ser Leu Thr Leu Ala Ile Asp Ser Cys His Gly Thr
                  85                  90                  95    
 Val Val Ala Leu Arg Tyr Ala Trp Thr Thr Trp Pro Cys Glu Tyr Lys
             100                 105                 110        
 Gln Cys Pro Leu Tyr His Pro Ser Ser Ala Leu Pro Ala Pro Pro Phe
         115                 120                 125            
 Ile Ala Phe Ile Thr Asp Gln Gly
     130                 135    



      <210> 3040
      <211> 90
      <212> PRT
      <213> Homo sapiens


      <400> 3040
 Met Thr Ser Asp Cys Gln Leu Gly Thr Arg Gln Tyr Leu Cys Arg Ser
   1               5                  10                  15    
 Trp Gln Lys Leu Tyr Phe Pro Ala Arg Val Cys Arg Tyr Ile Arg Ile
              20                  25                  30        
 Val Gly Thr His Asn Thr Val Asn Lys Ile Phe His Ile Val Ala Phe
          35                  40                  45            
 Glu Cys Met Phe Thr Asn Lys Thr Phe Thr Leu Glu Lys Gly Leu Ile
      50                  55                  60                
 Gly Tyr Tyr Phe Gly Ile Val Thr Leu Lys Val Asp Thr Val Glu His
  65                  70                  75                  80
 Leu Gly Glu Lys Arg Lys Arg Pro His Glu
                  85                  90



      <210> 3041
      <211> 253
      <212> PRT
      <213> Homo sapiens


      <400> 3041
 Met Ala Met Gly Val Pro Arg Val Ile Leu Leu Cys Leu Phe Gly Ala
   1               5                  10                  15    
 Ala Leu Cys Leu Thr Gly Ser Gln Ala Leu Gln Cys Tyr Ser Phe Glu
              20                  25                  30        
 His Thr Tyr Phe Gly Pro Phe Asp Leu Arg Ala Met Lys Leu Pro Ser
          35                  40                  45            
 Ile Ser Cys Pro His Glu Cys Phe Glu Ala Ile Leu Ser Leu Asp Thr
      50                  55                  60                
 Gly Tyr Arg Ala Pro Val Thr Leu Val Arg Lys Gly Cys Trp Thr Gly
  65                  70                  75                  80
 Pro Pro Ala Gly Gln Thr Gln Ser Asn Ala Asp Ala Leu Pro Pro Asp
                  85                  90                  95    
 Tyr Ser Val Val Arg Gly Cys Thr Thr Asp Lys Cys Asn Ala His Leu
             100                 105                 110        
 Met Thr His Asp Ala Leu Pro Asn Leu Ser Gln Ala Pro Asp Pro Pro
         115                 120                 125            
 Thr Leu Ser Gly Leu Glu Cys Tyr Ala Cys Ile Gly Val His Gln Asp
     130                 135                 140                
 Asp Cys Ala Ile Gly Arg Ser Arg Arg Val Gln Cys His Gln Asp Gln
 145                 150                 155                 160
 Thr Ala Cys Phe Gln Gly Asn Gly Arg Met Thr Val Gly Asn Phe Ser
                 165                 170                 175    
 Val Pro Val Tyr Ile Arg Thr Cys His Arg Ala Leu Leu His His Leu
             180                 185                 190        
 Met Gly Thr Thr Ser Pro Trp Thr Ala Ile Gly Pro Pro Arg Gly Ser
         195                 200                 205            
 Cys Cys Glu Gly Tyr Leu Cys Asn Arg Lys Ser Met Thr Gln Pro Phe
     210                 215                 220                
 Thr Ser Ala Ser Ala Thr Thr Pro Pro Arg Ala Leu Gln Val Leu Ala
 225                 230                 235                 240
 Leu Leu Leu Pro Val Leu Leu Leu Val Gly Leu Ser Ala
                 245                 250            



      <210> 3042
      <211> 551
      <212> PRT
      <213> Homo sapiens

      <220>
      <221> misc_feature
      <222> (1)...(551)
      <223> Xaa = any amino acid or symbol as shown in the table 8 as set forth in Example 2


      <400> 3042
 Met Gly Thr Val Pro Arg Ser Ala Gly Gln Glu Thr Trp Val Leu Cys
   1               5                  10                  15    
 Glu His Ile Ile Gly Gly Glu Arg Ser Phe Thr Glu Tyr Ser Leu Cys
              20                  25                  30        
 His Arg Ile Glu Ser Ser Thr Ser Ser Ile Lys Leu Glu Leu Gly Gly
          35                  40                  45            
 Asn Asn Val Glu Pro Leu Glu Ser Ser Arg Val Phe Asp Ser Thr Val
      50                  55                  60                
 Gln Asn Glu Glu Ala Asp Ala Val Ser Thr Gly Glu Glu Gly Val Thr
  65                  70                  75                  80
 His Glu Gly Thr Gln Gly Gly Lys Val Ile Pro Gln Met His Met Gly
                  85                  90                  95    
 Ser Gly Leu Gln Pro Lys Ser Phe Ser Gln Asn Arg Ser Gln Val Asn
             100                 105                 110        
 Asn Asp Met Ile Val Thr Asp Asn Asn Gly Ala Val Lys Phe Pro Gln
         115                 120                 125            
 Leu Cys Lys Phe Cys Asp Val Arg Phe Ser Thr Cys Asp Asn Gln Lys
     130                 135                 140                
 Ser Cys Met Ser Asn Cys Ser Ile Thr Ser Ile Cys Glu Lys Pro Gln
 145                 150                 155                 160
 Glu Val Cys Val Ala Val Cys Trp Met Ser Glu Glu Ile Cys Thr Asn
                 165                 170                 175    
 Val Met Tyr Ser Pro Leu Pro Cys Lys Phe Leu His Leu Ser Pro Ile
             180                 185                 190        
 Glu Val Leu Pro Ile Ile Arg Ser Pro Val Asn Gln Ser Gly Arg Cys
         195                 200                 205            
 Lys Ile Arg His Ile Gly Ser Asn Asn Arg Leu Gln Arg Ser Thr Cys
     210                 215                 220                
 Gln Asn Thr Gly Trp Glu Ser Ala His Val Met Lys Thr Pro Gly Phe
 225                 230                 235                 240
 Arg Glu Tyr Asn Thr Ser Asn Pro Asp Leu Leu Leu Val Ile Phe Gln
                 245                 250                 255    
 Val Thr Gly Ile Ser Leu Leu Pro Pro Leu Gly Val Ala Ile Ser Val
             260                 265                 270        
 Ile Ile Ile Phe Tyr Cys Tyr Arg Val Asn Arg Gln Gln Lys Leu Ser
         275                 280                 285            
 Ser Thr Trp Glu Thr Gly Lys Thr Arg Lys Leu Met Glu Phe Ser Glu
     290                 295                 300                
 His Cys Ala Ile Ile Leu Glu Asp Asp Arg Ser Asp Ile Ser Ser Thr
 305                 310                 315                 320
 Cys Ala Asn Asn Ile Asn His Asn Thr Glu Leu Leu Pro Ile Glu Leu
                 325                 330                 335    
 Asp Thr Leu Val Gly Lys Gly Arg Phe Ala Glu Val Tyr Lys Ala Lys
             340                 345                 350        
 Leu Lys Gln Asn Thr Ser Glu Gln Phe Xaa Asp Ser Gly Gln Phe Lys
         355                 360                 365            
 Ile Leu Phe Pro Ile Glu Glu Tyr Ala Ser Trp Lys Thr Glu Lys Asp
     370                 375                 380                
 Ile Phe Ser Asp Ile Asn Leu Lys His Glu Asn Ile Leu Gln Phe Leu
 385                 390                 395                 400
 Thr Ala Glu Glu Arg Lys Thr Glu Leu Gly Lys Gln Tyr Trp Leu Ile
                 405                 410                 415    
 Thr Ala Phe His Ala Lys Gly Asn Leu Gln Glu Tyr Leu Thr Arg His
             420                 425                 430        
 Val Ile Ser Trp Glu Asp Leu Arg Lys Leu Gly Ser Ser Leu Ala Arg
         435                 440                 445            
 Gly Ile Ala His Leu His Ser Asp His Thr Pro Cys Gly Arg Pro Lys
     450                 455                 460                
 Met Pro Ile Val His Arg Asp Leu Lys Ser Ser Asn Ile Leu Val Lys
 465                 470                 475                 480
 Asn Asp Leu Thr Cys Cys Leu Cys Asp Phe Gly Leu Ser Leu Arg Leu
                 485                 490                 495    
 Asp Pro Thr Leu Ser Val Asp Asp Leu Ala Asn Ser Gly Gln Cys Tyr
             500                 505                 510        
 Glu Val Cys Ser Ser Gly Arg Phe Leu Val Thr Ile Phe Lys Gly Asn
         515                 520                 525            
 Arg Leu Arg Glu Arg Thr Glu Lys Asn Thr Arg Ile Thr Pro Arg Asp
     530                 535                 540                
 Trp Val Tyr Glu Trp Leu Trp
 545                 550    



      <210> 3043
      <211> 535
      <212> PRT
      <213> Homo sapiens


      <400> 3043
 Ser Glu Leu Leu Leu Thr Phe Ser Phe Arg Leu Arg Met Thr Gln Asn
   1               5                  10                  15    
 Lys Leu Lys Leu Cys Ser Lys Ala Asn Val Tyr Thr Glu Val Pro Asp
              20                  25                  30        
 Gly Gly Trp Gly Trp Ala Val Ala Val Ser Phe Phe Phe Val Glu Val
          35                  40                  45            
 Phe Thr Tyr Gly Ile Ile Lys Thr Phe Gly Val Phe Phe Asn Asp Leu
      50                  55                  60                
 Met Asp Ser Phe Asn Glu Ser Asn Ser Arg Ile Ser Trp Ile Ile Ser
  65                  70                  75                  80
 Ile Cys Val Phe Val Leu Thr Phe Ser Ala Pro Leu Ala Thr Val Leu
                  85                  90                  95    
 Ser Asn Arg Phe Gly His Arg Leu Val Val Met Leu Gly Gly Leu Leu
             100                 105                 110        
 Val Ser Thr Gly Met Val Ala Ala Ser Phe Ser Gln Glu Val Ser His
         115                 120                 125            
 Met Tyr Val Ala Ile Gly Ile Ile Ser Gly Leu Gly Tyr Cys Phe Ser
     130                 135                 140                
 Phe Leu Pro Thr Val Thr Ile Leu Ser Gln Tyr Phe Gly Lys Arg Arg
 145                 150                 155                 160
 Ser Ile Val Thr Ala Val Ala Ser Thr Gly Glu Cys Phe Ala Val Phe
                 165                 170                 175    
 Ala Phe Ala Pro Ala Ile Met Ala Leu Lys Glu Arg Ile Gly Trp Arg
             180                 185                 190        
 Tyr Ser Leu Leu Phe Val Gly Leu Leu Gln Leu Asn Ile Val Ile Phe
         195                 200                 205            
 Gly Ala Leu Leu Arg Pro Ile Phe Ile Arg Gly Pro Ala Ser Pro Lys
     210                 215                 220                
 Ile Val Ile Gln Glu Asn Arg Lys Glu Ala Gln Tyr Met Leu Glu Asn
 225                 230                 235                 240
 Glu Lys Thr Arg Thr Ser Ile Asp Ser Ile Asp Ser Gly Val Glu Leu
                 245                 250                 255    
 Thr Thr Ser Pro Lys Asn Val Pro Thr His Thr Asn Leu Glu Leu Glu
             260                 265                 270        
 Pro Lys Ala Asp Met Gln Gln Val Leu Val Lys Thr Ser Pro Arg Pro
         275                 280                 285            
 Ser Glu Lys Lys Ala Pro Leu Leu Asp Phe Ser Ile Leu Lys Glu Lys
     290                 295                 300                
 Ser Phe Ile Cys Tyr Ala Leu Phe Gly Leu Phe Ala Thr Leu Gly Phe
 305                 310                 315                 320
 Phe Ala Pro Ser Leu Tyr Ile Ile Pro Leu Gly Ile Ser Leu Gly Ile
                 325                 330                 335    
 Asp Gln Asp Arg Ala Ala Phe Leu Leu Ser Thr Met Ala Ile Ala Glu
             340                 345                 350        
 Val Phe Gly Arg Ile Gly Ala Gly Phe Val Leu Asn Arg Glu Pro Ile
         355                 360                 365            
 Arg Lys Ile Tyr Ile Glu Leu Ile Cys Val Ile Leu Leu Thr Val Ser
     370                 375                 380                
 Leu Phe Ala Phe Thr Phe Ala Thr Glu Phe Trp Gly Leu Met Ser Cys
 385                 390                 395                 400
 Ser Ile Phe Phe Gly Phe Met Val Gly Thr Ile Gly Gly Leu Thr Phe
                 405                 410                 415    
 His Cys Leu Leu Arg Met Met Ser Trp Ala Leu Gln Lys Met Ser Ser
             420                 425                 430        
 Ala Ala Gly Val Tyr Ile Phe Ile Gln Ser Ile Ala Gly Leu Ala Gly
         435                 440                 445            
 Pro Pro Leu Ala Gly Leu Leu Val Asp Gln Ser Lys Ile Tyr Ser Arg
     450                 455                 460                
 Ala Phe Tyr Ser Cys Ala Ala Gly Met Ala Leu Ala Ala Val Cys Leu
 465                 470                 475                 480
 Ala Leu Val Arg Pro Cys Lys Met Gly Leu Cys Gln His His His Ser
                 485                 490                 495    
 Gly Glu Thr Lys Val Val Ser His Arg Gly Lys Thr Leu Gln Asp Ile
             500                 505                 510        
 Pro Glu Asp Phe Leu Glu Met Asp Leu Ala Lys Asn Glu His Arg Val
         515                 520                 525            
 His Val Gln Met Glu Pro Val
     530                 535



      <210> 3044
      <211> 516
      <212> PRT
      <213> Homo sapiens


      <400> 3044
 Phe Arg Val Leu Lys Lys Ala Ser Arg Thr Ser Leu Gly His Gly Gly
   1               5                  10                  15    
 Asn Pro Ile Gln Ile Leu His Leu Pro Thr Gln Leu Val Thr Asn Phe
              20                  25                  30        
 Thr Gly Gly Pro Asp Asp Asn Leu Ile Glu Gly Gly Gly Thr Lys Phe
          35                  40                  45            
 Val Cys Lys Pro Gly Ala Arg Asn Ile Thr Val Ile Phe His Pro Leu
      50                  55                  60                
 Leu Arg Phe Ile Gln Glu Ile Glu His Ala Leu Gly Leu Gly Pro Ala
  65                  70                  75                  80
 Lys Gln Cys Pro Leu Arg Glu Phe Leu Thr Val Tyr Ile Lys Asn Ile
                  85                  90                  95    
 Phe Leu Asn Gln Val Leu Ala Glu Ile Asn Lys Glu Ile Glu Gly Val
             100                 105                 110        
 Thr Lys Thr Ser Asp Pro Leu Lys Ile Leu Ala Asn Ala Asp Thr Met
         115                 120                 125            
 Lys Val Leu Gly Val Gln Arg Pro Leu Leu Gln Ser Thr Ile Ile Val
     130                 135                 140                
 Glu Lys Thr Val Gln Asp Leu Leu Asn Leu Met His Asp Leu Ser Ala
 145                 150                 155                 160
 Tyr Ser Asp Gln Phe Leu Asn Met Val Cys Val Lys Leu Gln Glu Tyr
                 165                 170                 175    
 Lys Asp Thr Cys Thr Ala Ala Tyr Arg Gly Ile Val Gln Ser Glu Glu
             180                 185                 190        
 Lys Leu Val Ile Ser Ala Ser Trp Ala Lys Asp Asp Asp Ile Ser Arg
         195                 200                 205            
 Leu Leu Lys Ser Leu Pro Asn Trp Met Asn Met Ala Gln Pro Lys Gln
     210                 215                 220                
 Leu Arg Pro Lys Arg Glu Glu Glu Glu Asp Phe Ile Arg Ala Ala Phe
 225                 230                 235                 240
 Gly Lys Glu Ser Glu Val Leu Ile Gly Asn Leu Gly Asp Lys Leu Ile
                 245                 250                 255    
 Pro Pro Gln Asp Ile Leu Arg Asp Val Ser Asp Leu Lys Ala Leu Ala
             260                 265                 270        
 Asn Met His Glu Ser Leu Glu Trp Leu Ala Ser Arg Thr Lys Ser Ala
         275                 280                 285            
 Phe Ser Asn Leu Ser Thr Ser Gln Met Leu Ser Pro Ala Gln Asp Ser
     290                 295                 300                
 His Thr Asn Thr Asp Leu Pro Pro Val Ser Glu Gln Ile Met Gln Thr
 305                 310                 315                 320
 Leu Ser Glu Leu Ala Lys Ser Phe Gln Asp Met Ala Asp Arg Cys Leu
                 325                 330                 335    
 Leu Val Leu His Leu Glu Val Arg Val His Cys Phe His Tyr Leu Ile
             340                 345                 350        
 Pro Leu Ala Lys Glu Gly Asn Tyr Gly His Cys Gly Leu Met Trp Glu
         355                 360                 365            
 Ser Met Asp Tyr Asp Pro Leu Val Val Lys Leu Asn Lys Asp Ile Ser
     370                 375                 380                
 Ala Ile Glu Glu Ala Met Ser Ala Ser Leu Gln Gln His Lys Phe Gln
 385                 390                 395                 400
 Tyr Ile Phe Glu Gly Leu Gly His Leu Ile Ser Cys Ile Leu Ile Asn
                 405                 410                 415    
 Gly Ala Gln Tyr Phe Arg Arg Ile Ser Glu Ser Gly Ile Lys Lys Met
             420                 425                 430        
 Cys Arg Asn Ile Phe Val Leu Gln Gln Asn Leu Thr Asn Ile Thr Met
         435                 440                 445            
 Ser Arg Glu Ala Asp Leu Asp Phe Ala Arg Gln Tyr Tyr Glu Met Leu
     450                 455                 460                
 Tyr Asn Thr Ala Asp Glu Leu Leu Asn Leu Val Val Asp Gln Gly Val
 465                 470                 475                 480
 Lys Tyr Thr Glu Leu Glu Tyr Ile His Ala Leu Thr Leu Leu His Arg
                 485                 490                 495    
 Ser Gln Thr Gly Val Gly Glu Leu Thr Thr Gln Asn Thr Arg Leu Gln
             500                 505                 510        
 Arg Leu Lys Glu
         515    



      <210> 3045
      <211> 100
      <212> PRT
      <213> Homo sapiens


      <400> 3045
 Ala Gly Gly Gly Gly Gly Thr Arg Arg Ala Leu Gly Val Pro Val Ala
   1               5                  10                  15    
 Arg Arg Arg Arg Met Trp Arg Ala Glu Gly Lys Trp Leu Pro Lys Thr
              20                  25                  30        
 Ser Arg Lys Ser Val Ser Gln Ser Val Phe Cys Gly Thr Ser Thr Tyr
          35                  40                  45            
 Cys Val Leu Asn Thr Val Pro Pro Ile Glu Asp Asp His Gly Asn Ser
      50                  55                  60                
 Asn Ser Ser His Val Lys Ile Phe Leu Pro Lys Lys Leu Leu Glu Cys
  65                  70                  75                  80
 Leu Pro Lys Cys Ser Ser Leu Pro Lys Glu Arg His Arg Trp Asn Thr
                  85                  90                  95    
 Asn Glu Arg Ser
             100



      <210> 3046
      <211> 102
      <212> PRT
      <213> Homo sapiens


      <400> 3046
 Val Pro Thr Asn Trp Phe Lys Lys Arg Gly Asp Lys His Ala Gly Pro
   1               5                  10                  15    
 Cys Trp Ala Ser Met Ala Pro Pro Ser Arg His Cys Leu Leu Leu Ile
              20                  25                  30        
 Ser Thr Leu Gly Val Phe Ala Leu Asn Cys Phe Thr Lys Gly Gln Lys
          35                  40                  45            
 Asn Ser Thr Leu Ile Phe Thr Arg Glu Asn Thr Ile Arg Asn Cys Ser
      50                  55                  60                
 Cys Ser Ala Asp Ile Arg Asp Cys Asp Tyr Ser Leu Ala Asn Leu Met
  65                  70                  75                  80
 Cys Asn Cys Lys Thr Val Leu Pro Leu Ala Val Arg Ser Glu Pro Ala
                  85                  90                  95    
 Thr Met Gly Leu Leu Thr
             100        



      <210> 3047
      <211> 348
      <212> PRT
      <213> Homo sapiens


      <400> 3047
 Arg Leu Ser Ser His Phe Ser Gln Cys Ser Pro Ser Ile Tyr Cys Thr
   1               5                  10                  15    
 Lys Phe Asp Lys Gln Gly Asn Val Thr Ser Phe Glu Arg Lys Lys Thr
              20                  25                  30        
 Glu Leu Tyr Gln Glu Leu Gly Leu Gln Ala Arg Asp Leu Arg Phe Gln
          35                  40                  45            
 His Val Met Ser Ile Thr Val Arg Asn Asn Arg Ile Ile Met Arg Met
      50                  55                  60                
 Glu Tyr Leu Lys Ala Val Ile Thr Pro Glu Cys Leu Leu Ile Leu Asp
  65                  70                  75                  80
 Tyr Arg Asn Leu Asn Leu Lys Gln Trp Leu Phe Arg Glu Leu Pro Ser
                  85                  90                  95    
 Gln Leu Ser Gly Glu Gly Gln Leu Val Thr Tyr Pro Leu Pro Phe Glu
             100                 105                 110        
 Phe Arg Ala Ile Glu Ala Leu Leu Gln Tyr Trp Ile Asn Thr Leu Gln
         115                 120                 125            
 Gly Lys Leu Ser Ile Leu Gln Pro Leu Ile Leu Glu Thr Leu Asp Ala
     130                 135                 140                
 Leu Gly Asp Pro Lys His Ser Ser Val Asp Arg Ser Lys Leu His Ile
 145                 150                 155                 160
 Leu Leu Gln Asn Gly Lys Ser Leu Ser Glu Leu Glu Thr Asp Ile Lys
                 165                 170                 175    
 Ile Phe Lys Glu Ser Ile Leu Glu Ile Leu Asp Glu Glu Glu Leu Leu
             180                 185                 190        
 Glu Glu Leu Cys Val Ser Lys Trp Ser Asp Pro Gln Val Phe Glu Lys
         195                 200                 205            
 Ser Ser Ala Gly Ile Asp His Ala Glu Glu Met Glu Leu Leu Leu Glu
     210                 215                 220                
 Asn Tyr Tyr Arg Leu Ala Asp Asp Leu Ser Asn Ala Ala Arg Glu Leu
 225                 230                 235                 240
 Arg Val Leu Ile Asp Asp Ser Gln Ser Ile Ile Phe Ile Asn Leu Asp
                 245                 250                 255    
 Ser His Arg Asn Val Met Met Arg Leu Asn Leu Gln Leu Thr Met Gly
             260                 265                 270        
 Thr Phe Ser Leu Ser Leu Phe Gly Leu Met Gly Val Ala Phe Gly Met
         275                 280                 285            
 Asn Leu Glu Ser Ser Leu Glu Glu Asp His Arg Ile Phe Trp Leu Ile
     290                 295                 300                
 Thr Gly Ile Met Phe Met Gly Ser Gly Leu Ile Trp Arg Arg Leu Leu
 305                 310                 315                 320
 Ser Phe Leu Gly Arg Leu Ala Arg Ser Ser Ile Ala Ser Tyr Gly Met
                 325                 330                 335    
 Lys Asp Met Val His Gly Gly Ile Val Glu Gly Leu
             340                 345            



      <210> 3048
      <211> 174
      <212> PRT
      <213> Homo sapiens


      <400> 3048
 Asn Ser Arg Val Asp Asp Phe Val Ala Ala Gly Gly Gly Gly Gly Ser
   1               5                  10                  15    
 Ser Lys Ala Ser Ser Ser Ser Ala Ser Ser Ala Gly Ala Leu Glu Ser
              20                  25                  30        
 Ser Leu Asp Arg Lys Phe Gln Ser Val Thr Asn Thr Met Glu Ser Ile
          35                  40                  45            
 Gln Gly Leu Ser Ser Trp Cys Ile Glu Asn Lys Lys His His Ser Thr
      50                  55                  60                
 Ile Val Tyr His Trp Met Lys Trp Leu Arg Arg Ser Ala Tyr Pro His
  65                  70                  75                  80
 Arg Leu Asn Leu Phe Tyr Leu Ala Asn Asp Val Ile Gln Asn Cys Lys
                  85                  90                  95    
 Arg Lys Asn Ala Ile Ile Phe Arg Glu Ser Phe Ala Asp Val Leu Pro
             100                 105                 110        
 Glu Ala Ala Ala Leu Val Lys Asp Pro Ser Val Ser Lys Ser Val Glu
         115                 120                 125            
 Arg Ile Phe Lys Ile Trp Glu Asp Arg Asn Val Tyr Pro Glu Glu Met
     130                 135                 140                
 Ile Val Ala Leu Arg Glu Ala Leu Ser Thr Thr Phe Lys Thr Gln Lys
 145                 150                 155                 160
 Gln Leu Lys Glu Asn Leu Asn Lys Gln Pro Asn Lys Gln Cys
                 165                 170                



      <210> 3049
      <211> 196
      <212> PRT
      <213> Homo sapiens


      <400> 3049
 His Gly Leu Cys Glu Leu Thr Ser Thr Val Gln Glu Gly Glu Leu Cys
   1               5                  10                  15    
 Val Phe Phe Arg Asn Asn His Phe Ser Thr Met Thr Lys Tyr Lys Gly
              20                  25                  30        
 Gln Leu Tyr Leu Leu Val Thr Asp Gln Gly Phe Leu Thr Glu Glu Lys
          35                  40                  45            
 Val Val Trp Glu Ser Leu His Asn Val Asp Gly Asp Gly Asn Phe Cys
      50                  55                  60                
 Asp Ser Glu Phe His Leu Arg Pro Pro Ser Asp Pro Glu Thr Val Tyr
  65                  70                  75                  80
 Lys Gly Gln Gln Asp Gln Ile Asp Gln Asp Tyr Leu Met Ala Leu Ser
                  85                  90                  95    
 Leu Gln Gln Glu Gln Gln Ser Gln Glu Ile Asn Trp Glu Gln Ile Pro
             100                 105                 110        
 Glu Gly Ile Ser Asp Leu Glu Leu Ala Lys Lys Leu Gln Glu Glu Glu
         115                 120                 125            
 Asp Arg Arg Ala Ser Gln Tyr Tyr Gln Glu Gln Glu Gln Ala Ala Ala
     130                 135                 140                
 Ala Ala Ala Ala Ala Ser Thr Gln Ala Gln Gln Gly Gln Pro Ala Gln
 145                 150                 155                 160
 Ala Ser Pro Ser Ser Gly Arg Gln Ser Gly Asn Ser Glu Arg Lys Arg
                 165                 170                 175    
 Lys Glu Pro Arg Glu Lys Asp Lys Glu Lys Glu Lys Glu Lys Asn Ser
             180                 185                 190        
 Cys Val Ile Leu
         195    



      <210> 3050
      <211> 579
      <212> PRT
      <213> Homo sapiens


      <400> 3050
 Asp Pro Arg Val Arg Pro Arg Val Arg Leu Ala Ser Glu Ala Ala Met
   1               5                  10                  15    
 Ser Tyr Pro Ala Asp Asp Tyr Glu Ser Glu Ala Ala Tyr Asp Pro Tyr
              20                  25                  30        
 Ala Tyr Pro Ser Asp Tyr Asp Met His Thr Gly Asp Pro Lys Gln Asp
          35                  40                  45            
 Leu Ala Tyr Glu Arg Gln Tyr Glu Gln Gln Thr Tyr Gln Val Ile Pro
      50                  55                  60                
 Glu Val Ile Lys Asn Phe Ile Gln Tyr Phe His Lys Thr Val Ser Asp
  65                  70                  75                  80
 Leu Ile Asp Gln Lys Val Tyr Glu Leu Gln Ala Ser Arg Val Ser Ser
                  85                  90                  95    
 Asp Val Ile Asp Gln Lys Val Tyr Glu Ile Gln Asp Ile Tyr Glu Asn
             100                 105                 110        
 Ser Trp Thr Lys Leu Thr Glu Arg Phe Phe Lys Asn Thr Pro Trp Pro
         115                 120                 125            
 Glu Ala Glu Ala Ile Ala Pro Gln Val Gly Asn Asp Ala Val Phe Leu
     130                 135                 140                
 Ile Leu Tyr Lys Glu Leu Tyr Tyr Arg His Ile Tyr Ala Lys Val Ser
 145                 150                 155                 160
 Gly Gly Pro Ser Leu Glu Gln Arg Phe Glu Ser Tyr Tyr Asn Tyr Cys
                 165                 170                 175    
 Asn Leu Phe Asn Tyr Ile Leu Asn Ala Asp Gly Pro Ala Pro Leu Glu
             180                 185                 190        
 Leu Pro Asn Gln Trp Leu Trp Asp Ile Ile Asp Glu Phe Ile Tyr Gln
         195                 200                 205            
 Phe Gln Ser Phe Ser Gln Tyr Arg Cys Lys Thr Ala Lys Lys Ser Glu
     210                 215                 220                
 Glu Glu Ile Asp Phe Leu Arg Ser Asn Pro Lys Ile Trp Asn Val His
 225                 230                 235                 240
 Ser Val Leu Asn Val Leu His Ser Leu Val Asp Lys Ser Asn Ile Asn
                 245                 250                 255    
 Arg Gln Leu Glu Val Tyr Thr Ser Gly Gly Asp Pro Glu Ser Val Ala
             260                 265                 270        
 Gly Glu Tyr Gly Arg His Ser Leu Tyr Lys Met Leu Gly Tyr Phe Ser
         275                 280                 285            
 Leu Val Gly Leu Leu Arg Leu His Ser Leu Leu Gly Asp Tyr Tyr Gln
     290                 295                 300                
 Ala Ile Lys Val Leu Glu Asn Ile Glu Leu Asn Lys Lys Ser Met Tyr
 305                 310                 315                 320
 Ser Arg Val Pro Glu Cys Gln Val Thr Thr Tyr Tyr Tyr Val Gly Phe
                 325                 330                 335    
 Ala Tyr Leu Met Met Arg Arg Tyr Gln Asp Ala Ile Arg Val Phe Ala
             340                 345                 350        
 Asn Ile Leu Leu Tyr Ile Gln Arg Thr Lys Ser Met Phe Gln Arg Thr
         355                 360                 365            
 Thr Tyr Lys Tyr Glu Met Ile Asn Lys Gln Asn Glu Gln Met His Ala
     370                 375                 380                
 Leu Leu Ala Ile Ala Leu Thr Met Tyr Pro Met Arg Ile Asp Glu Ser
 385                 390                 395                 400
 Ile His Leu Gln Leu Arg Glu Lys Tyr Gly Asp Lys Met Leu Arg Met
                 405                 410                 415    
 Gln Lys Gly Asp Pro Gln Val Tyr Glu Glu Leu Phe Ser Tyr Ser Cys
             420                 425                 430        
 Pro Lys Phe Leu Ser Pro Val Val Pro Asn Tyr Asp Asn Val His Pro
         435                 440                 445            
 Asn Tyr His Lys Glu Pro Phe Leu Gln Gln Leu Lys Val Phe Ser Asp
     450                 455                 460                
 Glu Val Gln Gln Gln Ala Gln Leu Ser Thr Ile Arg Ser Phe Leu Lys
 465                 470                 475                 480
 Leu Tyr Thr Thr Met Pro Val Ala Lys Leu Ala Gly Phe Leu Asp Leu
                 485                 490                 495    
 Thr Glu Gln Glu Phe Arg Ile Gln Leu Leu Val Phe Lys His Lys Met
             500                 505                 510        
 Lys Asn Leu Val Trp Thr Ser Gly Ile Ser Ala Leu Asp Gly Glu Phe
         515                 520                 525            
 Gln Ser Ala Ser Glu Val Asp Phe Tyr Ile Asp Lys Asp Met Ile His
     530                 535                 540                
 Ile Ala Asp Thr Lys Val Ala Arg Arg Tyr Gly Asp Phe Phe Ile Arg
 545                 550                 555                 560
 Gln Ile His Lys Phe Glu Glu Leu Asn Arg Thr Leu Lys Lys Met Gly
                 565                 570                 575    
 Gln Arg Pro
            



      <210> 3051
      <211> 196
      <212> PRT
      <213> Homo sapiens

      <220>
      <221> misc_feature
      <222> (1)...(196)
      <223> Xaa = any amino acid or symbol as shown in the table 8 as set forth in Example 2


      <400> 3051
 Phe Phe Phe Leu Arg Trp Ser Leu Asp Ser Val Ala Gln Ala Gly Val
   1               5                  10                  15    
 Gln Trp Cys Asp Leu Gly Ser Leu Gln Ala Pro Pro Pro Gly Phe Thr
              20                  25                  30        
 Pro Phe Ser Cys Leu Ser Leu Pro Ser Ser Trp Asp Tyr Arg Arg Pro
          35                  40                  45            
 Pro Pro Arg Pro Ala Asn Phe Leu Tyr Phe Xaa Xaa Arg Arg Gly Phe
      50                  55                  60                
 Thr Val Leu Ala Arg Met Val Ser Ile Ser Xaa Pro Arg Asp Pro Pro
  65                  70                  75                  80
 Ala Ser Ala Ser Gln Ser Ala Gly Ile Thr Gly Val Ser His Arg Ala
                  85                  90                  95    
 Arg Leu Gln Ile Ile Phe Leu Phe Phe Phe Phe Ser Glu Thr Glu Ser
             100                 105                 110        
 Arg Ser Val Ala Gln Ala Gly Val Gln Trp Arg Asp Leu Gly Ser Arg
         115                 120                 125            
 His Ala Pro Pro Pro Gly Phe Thr Pro Phe Ser Cys Leu Ser Phe Pro
     130                 135                 140                
 Ser Ser Trp Asp Tyr Arg Gly Pro Pro Pro Arg Pro Ala Asn Phe Cys
 145                 150                 155                 160
 Cys Ile Phe Ser Arg Asp Gly Val Ser Pro Phe Xaa Pro Gly Trp Ser
                 165                 170                 175    
 Arg Ser Pro Asp Leu Val Ile Arg Pro Pro Gly Pro Pro Lys Val Leu
             180                 185                 190        
 Gly Leu Gln Ala
         195    



      <210> 3052
      <211> 72
      <212> PRT
      <213> Homo sapiens


      <400> 3052
 Met Leu Gly Ser Ile Cys Asn Val Met Leu Leu Met Leu Ala Ala Ser
   1               5                  10                  15    
 Ile Pro Glu Ile Cys Thr Phe Gly Pro Thr Lys Leu Ala Ala Asn Cys
              20                  25                  30        
 Asn Trp Met Pro Ser Arg Val Ala Arg Leu Pro Ser Val Arg Asp Thr
          35                  40                  45            
 Val Arg Ser Pro Pro Ala Asp Thr Glu Ala Gly Arg Ile Ala Trp Pro
      50                  55                  60                
 Thr Ser Pro Gly Cys Ser Arg Phe
  65                  70        



      <210> 3053
      <211> 746
      <212> PRT
      <213> Homo sapiens


      <400> 3053
 Lys Ile Phe Pro Phe Asp Ala Ser Phe Leu Pro Cys Leu His Lys Phe
   1               5                  10                  15    
 Asn Leu Lys Gly Lys Gly Asn Ser Lys Gly Phe Lys Met Ala Glu Lys
              20                  25                  30        
 Phe Glu Ser Leu Met Asn Ile His Gly Phe Asp Leu Gly Ser Arg Tyr
          35                  40                  45            
 Met Asp Leu Lys Pro Leu Gly Cys Gly Gly Asn Gly Leu Val Phe Ser
      50                  55                  60                
 Ala Val Asp Asn Asp Cys Asp Lys Arg Val Ala Ile Lys Lys Ile Val
  65                  70                  75                  80
 Leu Thr Asp Pro Gln Ser Val Lys His Ala Leu Arg Glu Ile Lys Ile
                  85                  90                  95    
 Ile Arg Arg Leu Asp His Asp Asn Ile Val Lys Val Phe Glu Ile Leu
             100                 105                 110        
 Gly Pro Ser Gly Ser Gln Leu Thr Asp Asp Val Gly Ser Leu Thr Glu
         115                 120                 125            
 Leu Asn Ser Val Tyr Ile Val Gln Glu Tyr Met Glu Thr Asp Leu Ala
     130                 135                 140                
 Asn Val Leu Glu Gln Gly Pro Leu Leu Glu Glu His Ala Arg Leu Phe
 145                 150                 155                 160
 Met Tyr Gln Leu Leu Arg Gly Leu Lys Tyr Ile His Ser Ala Asn Val
                 165                 170                 175    
 Leu His Arg Asp Leu Lys Pro Ala Asn Leu Phe Ile Asn Thr Glu Asp
             180                 185                 190        
 Leu Val Leu Lys Ile Gly Asp Phe Gly Leu Ala Arg Ile Met Asp Pro
         195                 200                 205            
 His Tyr Ser His Lys Gly His Leu Ser Glu Gly Leu Val Thr Lys Trp
     210                 215                 220                
 Tyr Arg Ser Pro Arg Leu Leu Leu Ser Pro Asn Asn Tyr Thr Lys Ala
 225                 230                 235                 240
 Ile Asp Met Trp Ala Ala Gly Cys Ile Phe Ala Glu Met Leu Thr Gly
                 245                 250                 255    
 Lys Thr Leu Phe Ala Gly Ala His Glu Leu Glu Gln Met Gln Leu Ile
             260                 265                 270        
 Leu Glu Ser Ile Pro Val Val His Glu Glu Asp Arg Gln Glu Leu Leu
         275                 280                 285            
 Ser Val Ile Pro Val Tyr Ile Arg Asn Asp Met Thr Glu Pro His Lys
     290                 295                 300                
 Pro Leu Thr Gln Leu Leu Pro Gly Ile Ser Arg Glu Ala Leu Asp Phe
 305                 310                 315                 320
 Leu Glu Gln Ile Leu Thr Phe Ser Pro Met Asp Arg Leu Thr Ala Glu
                 325                 330                 335    
 Glu Ala Leu Ser His Pro Tyr Met Ser Ile Tyr Ser Phe Pro Met Asp
             340                 345                 350        
 Glu Pro Ile Ser Ser His Pro Phe His Ile Glu Asp Glu Val Asp Asp
         355                 360                 365            
 Ile Leu Leu Met Asp Glu Thr His Ser His Ile Tyr Asn Trp Glu Arg
     370                 375                 380                
 Tyr His Asp Cys Gln Phe Ser Glu His Asp Trp Pro Val His Asn Asn
 385                 390                 395                 400
 Phe Asp Ile Asp Glu Val Gln Leu Asp Pro Arg Ala Leu Ser Asp Val
                 405                 410                 415    
 Thr Asp Glu Glu Glu Val Gln Val Asp Pro Arg Lys Tyr Leu Asp Gly
             420                 425                 430        
 Asp Arg Glu Lys Tyr Leu Glu Asp Pro Ala Phe Asp Thr Asn Tyr Ser
         435                 440                 445            
 Thr Glu Pro Cys Trp Gln Tyr Ser Asp His His Glu Asn Lys Tyr Cys
     450                 455                 460                
 Asp Leu Glu Cys Ser His Thr Cys Asn Tyr Lys Thr Arg Ser Ser Ser
 465                 470                 475                 480
 Tyr Leu Asp Asn Leu Val Trp Arg Glu Ser Glu Val Asn His Tyr Tyr
                 485                 490                 495    
 Glu Pro Lys Leu Ile Ile Asp Leu Ser Asn Trp Lys Glu Gln Ser Lys
             500                 505                 510        
 Glu Lys Ser Asp Lys Lys Gly Lys Ser Lys Cys Glu Arg Asn Gly Leu
         515                 520                 525            
 Val Lys Ala Gln Ile Ala Leu Glu Glu Ala Ser Gln Gln Leu Ala Gly
     530                 535                 540                
 Lys Glu Arg Glu Lys Asn Gln Gly Phe Asp Phe Asp Ser Phe Ile Ala
 545                 550                 555                 560
 Gly Thr Ile His Leu Ser Ser Gln His Glu Pro Thr Asp Val Gly Asp
                 565                 570                 575    
 Lys Leu Asn Asp Leu Asn Ser Ser Val Ser Gln Leu Glu Leu Lys Ser
             580                 585                 590        
 Leu Ile Ser Lys Ser Val Ser Gln Glu Lys Gln Glu Lys Gly Met Ala
         595                 600                 605            
 Asn Leu Ala Gln Leu Glu Ala Leu Tyr Gln Ser Ser Trp Asp Ser Gln
     610                 615                 620                
 Phe Val Ser Gly Gly Glu Asp Cys Phe Phe Ile Asn Gln Phe Cys Glu
 625                 630                 635                 640
 Val Arg Lys Asp Glu Gln Val Glu Lys Glu Asn Thr Tyr Thr Ser Tyr
                 645                 650                 655    
 Leu Asp Lys Phe Phe Ser Arg Lys Glu Asp Thr Glu Met Leu Glu Thr
             660                 665                 670        
 Glu Pro Val Glu Asp Gly Lys Leu Gly Glu Arg Gly His Glu Glu Gly
         675                 680                 685            
 Phe Leu Asn Asn Ser Gly Glu Phe Leu Phe Asn Lys Gln Leu Glu Ser
     690                 695                 700                
 Ile Gly Ile Pro Gln Phe His Ser Pro Val Gly Ser Pro Leu Lys Ser
 705                 710                 715                 720
 Ile Gln Ala Thr Leu Thr Pro Ser Ala Met Lys Ser Ser Pro Gln Ile
                 725                 730                 735    
 Pro His Gln Ser Asp Lys Gln Ala Ala Phe
             740                 745    



      <210> 3054
      <211> 276
      <212> PRT
      <213> Homo sapiens


      <400> 3054
 Ser Thr His Ala Ser Ala Asp Arg Ile Leu Asp Leu Gly Phe Glu Lys
   1               5                  10                  15    
 Asp Ile Thr Val Ile Leu Asn Ala Val Asn Ala Glu Cys Gln Lys Arg
              20                  25                  30        
 Gln Asn Val Leu Leu Ser Ala Thr Leu Thr Glu Gly Val Thr Arg Leu
          35                  40                  45            
 Ala Asp Ile Ser Leu His Asp Pro Val Ser Ile Ser Val Leu Asp Lys
      50                  55                  60                
 Ser His Asp Gln Leu Asn Pro Lys Asp Lys Ala Val Gln Glu Val Cys
  65                  70                  75                  80
 Pro Pro Pro Ala Gly Asp Lys Leu Asp Ser Phe Ala Ile Pro Glu Ser
                  85                  90                  95    
 Leu Lys Gln His Val Thr Val Val Pro Ser Lys Leu Arg Leu Val Cys
             100                 105                 110        
 Leu Ala Ala Phe Ile Leu Gln Lys Cys Lys Phe Glu Glu Asp Gln Lys
         115                 120                 125            
 Met Val Val Phe Phe Ser Ser Cys Glu Leu Val Glu Phe His Tyr Ser
     130                 135                 140                
 Leu Phe Leu Gln Thr Leu Leu Ser Ser Ser Gly Ala Pro Ala Ser Gly
 145                 150                 155                 160
 Gln Leu Pro Ser Ala Ser Met Arg Leu Lys Phe Leu Arg Leu His Gly
                 165                 170                 175    
 Gly Met Glu Gln Glu Glu Arg Thr Ala Val Phe Gln Glu Phe Ser His
             180                 185                 190        
 Ser Arg Arg Gly Val Leu Leu Cys Thr Asp Val Ala Ala Arg Gly Leu
         195                 200                 205            
 Asp Leu Pro Gln Val Thr Cys Asp Cys Ser Glu Tyr Ile His Arg Ile
     210                 215                 220                
 Gly Arg Thr Ala Arg Ile Gly Cys His Gly Ser Ser Leu Leu Ile Leu
 225                 230                 235                 240
 Ala Pro Ser Glu Ala Glu Tyr Val Asn Ser Leu Ala Ser His Lys Ile
                 245                 250                 255    
 Asn Val Ser Glu Ile Lys Met Glu Asp Ile Leu Cys Val Leu Thr Arg
             260                 265                 270        
 Asp Asp Trp Phe
         275    



      <210> 3055
      <211> 89
      <212> PRT
      <213> Homo sapiens


      <400> 3055
 Leu Pro Ser Arg Gly Ala Gly Leu Gly Thr Cys Ser Pro Pro Cys Leu
   1               5                  10                  15    
 Ser Leu Pro Pro Thr Pro Trp Ala Pro Val Arg Ser Glu Pro Pro Arg
              20                  25                  30        
 Arg Ala Pro Pro Pro Gly Ser Thr Val Pro Ser Pro Ile Asn His Pro
          35                  40                  45            
 Arg Ala Glu Glu Cys Glu Arg Met Ala Arg Asp Trp Gln Ala Ala Pro
      50                  55                  60                
 Pro Ala Ala Pro Val Arg Asp Pro Leu Gly Glu Ala Ser Trp Ala Pro
  65                  70                  75                  80
 Glu Phe Phe Gly Ser Met Leu Pro Leu
                  85                



      <210> 3056
      <211> 1542
      <212> PRT
      <213> Homo sapiens


      <400> 3056
 Met Arg Lys Asp Arg Leu Leu His Leu Cys Leu Val Leu Leu Leu Ile
   1               5                  10                  15    
 Leu Leu Ser Ala Ser Asp Ser Asn Ser Thr Glu Pro Gln Tyr Met Val
              20                  25                  30        
 Leu Val Pro Ser Leu Leu His Thr Glu Ala Pro Lys Lys Gly Cys Val
          35                  40                  45            
 Leu Leu Ser His Leu Asn Glu Thr Val Thr Val Ser Ala Ser Leu Glu
      50                  55                  60                
 Ser Gly Arg Glu Asn Arg Ser Leu Phe Thr Asp Leu Val Ala Glu Lys
  65                  70                  75                  80
 Asp Leu Phe His Cys Val Ser Phe Thr Leu Pro Arg Ile Ser Ala Ser
                  85                  90                  95    
 Ser Glu Val Ala Phe Leu Ser Ile Gln Ile Lys Gly Pro Thr Gln Asp
             100                 105                 110        
 Phe Arg Lys Arg Asn Thr Val Leu Val Leu Asn Thr Gln Ser Leu Val
         115                 120                 125            
 Phe Val Gln Thr Asp Lys Pro Met Tyr Lys Pro Gly Gln Thr Ala Ser
     130                 135                 140                
 Cys Leu Ile Thr Gln Ile Thr Cys Phe Ile Met Ser Glu Ser Tyr Arg
 145                 150                 155                 160
 Arg Thr Thr Phe Pro Val Arg Phe Arg Val Val Ser Val Asp Glu Asn
                 165                 170                 175    
 Phe Arg Pro Arg Asn Glu Leu Asn Pro Arg Arg Asn Arg Ile Ala Gln
             180                 185                 190        
 Trp Gln Ser Leu Lys Leu Glu Ala Gly Ile Asn Gln Leu Ser Phe Pro
         195                 200                 205            
 Leu Ser Ser Glu Pro Ile Gln Gly Ser Tyr Arg Val Val Val Gln Thr
     210                 215                 220                
 Glu Ser Gly Gly Arg Ile Gln His Pro Phe Thr Val Glu Glu Phe Val
 225                 230                 235                 240
 Leu Pro Lys Phe Glu Val Lys Val Gln Val Pro Lys Ile Ile Ser Ile
                 245                 250                 255    
 Met Asp Glu Lys Val Asn Ile Thr Val Cys Gly Glu Tyr Thr Tyr Gly
             260                 265                 270        
 Lys Pro Val Pro Gly Leu Ala Thr Val Ser Leu Cys Arg Lys Leu Ser
         275                 280                 285            
 Arg Val Leu Asn Cys Asp Lys Gln Glu Val Cys Glu Glu Phe Ser Gln
     290                 295                 300                
 Gln Leu Asn Ser Asn Gly Cys Ile Thr Gln Gln Val His Thr Lys Met
 305                 310                 315                 320
 Leu Gln Ile Thr Asn Thr Gly Phe Glu Met Lys Leu Arg Val Glu Ala
                 325                 330                 335    
 Arg Ile Arg Glu Glu Gly Thr Asp Leu Glu Val Thr Ala Asn Arg Ile
             340                 345                 350        
 Ser Glu Ile Thr Asn Ile Val Ser Lys Leu Lys Phe Val Lys Val Asp
         355                 360                 365            
 Ser His Phe Arg Gln Gly Ile Pro Phe Phe Ala Gln Val Leu Leu Val
     370                 375                 380                
 Asp Gly Lys Gly Val Pro Ile Pro Asn Lys Leu Phe Phe Ile Ser Val
 385                 390                 395                 400
 Asn Asp Ala Asn Tyr Tyr Ser Asn Ala Thr Thr Asn Glu Gln Gly Leu
                 405                 410                 415    
 Ala Gln Phe Ser Ile Asn Thr Thr Ser Ile Ser Val Asn Lys Leu Phe
             420                 425                 430        
 Val Arg Val Phe Thr Val His Pro Asn Leu Cys Phe His Tyr Ser Trp
         435                 440                 445            
 Val Ala Glu Asp His Gln Gly Ala Gln His Thr Ala Asn Arg Val Phe
     450                 455                 460                
 Ser Leu Ser Gly Ser Tyr Ile His Leu Glu Pro Val Ala Gly Thr Leu
 465                 470                 475                 480
 Pro Cys Gly His Thr Glu Thr Ile Thr Ala His Tyr Thr Leu Asn Arg
                 485                 490                 495    
 Gln Ala Met Gly Glu Leu Ser Glu Leu Ser Phe His Tyr Leu Ile Met
             500                 505                 510        
 Ala Lys Gly Val Ile Val Arg Ser Gly Thr His Thr Leu Pro Val Glu
         515                 520                 525            
 Ser Gly Asp Ser Ile His Ser Asn Asp His Gly Ser Met Thr Gln Gly
     530                 535                 540                
 Ile Gly Gly Ser Pro Leu Ala Thr Val His Ala Phe Ala Leu Thr Val
 545                 550                 555                 560
 Val Leu Ala Trp Gly Trp Gly Thr Val Lys Gly Ser Phe Ala Leu Ser
                 565                 570                 575    
 Phe Pro Val Glu Ser Asp Val Ala Pro Ile Ala Arg Met Phe Ile Phe
             580                 585                 590        
 Ala Ile Leu Pro Asp Gly Glu Val Val Gly Asp Ser Glu Lys Phe Glu
         595                 600                 605            
 Ile Glu Asn Cys Leu Ala Asn Lys Val Asp Leu Ser Phe Ser Pro Ala
     610                 615                 620                
 Gln Ser Pro Pro Ala Ser His Ala His Leu Gln Val Ala Ala Ala Pro
 625                 630                 635                 640
 Gln Ser Leu Cys Ala Leu Arg Ala Val Asp Gln Ser Val Leu Leu Met
                 645                 650                 655    
 Lys Pro Glu Ala Glu Leu Ser Val Ser Ser Val Tyr Asn Leu Leu Thr
             660                 665                 670        
 Val Lys Asp Leu Thr Asn Phe Pro Asp Asn Val Asp Gln Gln Glu Glu
         675                 680                 685            
 Glu Gln Gly His Cys Pro Arg Pro Phe Phe Ile His Asn Gly Ala Ile
     690                 695                 700                
 Tyr Val Pro Leu Ser Ser Asn Glu Ala Asp Ile Tyr Ser Phe Leu Lys
 705                 710                 715                 720
 Gly Met Gly Leu Lys Val Phe Thr Asn Ser Lys Ile Arg Lys Pro Lys
                 725                 730                 735    
 Ser Cys Ser Val Ile Pro Ser Val Ser Ala Gly Ala Val Gly Gln Gly
             740                 745                 750        
 Tyr Tyr Gly Gly Leu Gly Val Val Glu Arg Pro Tyr Val Pro Gln Leu
         755                 760                 765            
 Gly Thr Tyr Asn Val Ile Pro Leu Asn Asn Glu Gln Ser Ser Gly Pro
     770                 775                 780                
 Val Pro Glu Thr Val Arg Ser Tyr Phe Pro Glu Thr Trp Ile Trp Glu
 785                 790                 795                 800
 Leu Val Ala Val Asn Ser Ser Gly Val Ala Glu Val Gly Val Thr Val
                 805                 810                 815    
 Pro Asp Thr Ile Thr Glu Trp Lys Ala Gly Ala Phe Cys Leu Ser Glu
             820                 825                 830        
 Asp Ala Gly Leu Gly Ile Ser Ser Thr Ala Ser Leu Arg Ala Phe Gln
         835                 840                 845            
 Pro Phe Phe Val Glu Leu Thr Met Pro Tyr Ser Val Ile Arg Gly Glu
     850                 855                 860                
 Val Phe Thr Leu Lys Ala Thr Val Leu Asn Tyr Leu Pro Lys Cys Ile
 865                 870                 875                 880
 Arg Val Arg Lys Met Arg Val Asn Arg Lys Gly Asn Val Asn Phe Ser
                 885                 890                 895    
 Val Ser Ala Glu Ala Met Gln Ser Leu Glu Leu Cys Gly Asn Glu Val
             900                 905                 910        
 Val Glu Val Pro Glu Ile Lys Arg Lys Asp Thr Val Ile Lys Thr Leu
         915                 920                 925            
 Leu Val Glu Ala Glu Gly Ile Glu Gln Glu Lys Thr Phe Ser Ser Met
     930                 935                 940                
 Thr Cys Ala Ser Gly Ala Asn Val Ser Glu Gln Leu Ser Leu Lys Leu
 945                 950                 955                 960
 Pro Ser Asn Val Val Lys Glu Ser Ala Arg Ala Ser Phe Ser Val Leu
                 965                 970                 975    
 Gly Asp Ile Leu Gly Ser Ala Met Gln Asn Ile Gln Asn Leu Leu Gln
             980                 985                 990        
 Met Pro Tyr Gly Cys Gly Glu Gln Asn Met Val Leu Phe Ala Pro Asn
         995                1000                1005            
 Ile Tyr Val Leu Asn Tyr Leu Asn Glu Thr Gln Gln Leu Thr Gln Glu
    1010                1015                1020                
 Ile Lys Ala Lys Ala Val Gly Tyr Leu Ile Thr Gly Tyr Gln Arg Gln
1025                1030                1035                1040
 Leu Asn Tyr Lys His Gln Asp Gly Ser Tyr Ser Thr Phe Gly Glu Arg
                1045                1050                1055    
 Tyr Gly Arg Asn Gln Gly Asn Thr Trp Leu Thr Ala Phe Val Leu Lys
            1060                1065                1070        
 Thr Phe Ala Gln Ala Arg Ser Tyr Ile Phe Ile Asp Glu Ala His Ile
        1075                1080                1085            
 Thr Gln Ser Leu Thr Trp Leu Ser Gln Met Gln Lys Asp Asn Gly Cys
    1090                1095                1100                
 Phe Arg Ser Ser Gly Ser Leu Leu Asn Asn Ala Ile Lys Gly Gly Val
1105                1110                1115                1120
 Glu Asp Glu Ala Thr Leu Ser Ala Tyr Val Thr Ile Ala Leu Leu Glu
                1125                1130                1135    
 Ile Pro Leu Pro Val Thr Asn Pro Ile Val Arg Asn Ala Leu Phe Cys
            1140                1145                1150        
 Leu Glu Ser Ala Trp Asn Val Ala Lys Glu Gly Thr His Gly Ser His
        1155                1160                1165            
 Val Tyr Thr Lys Ala Leu Leu Ala Tyr Ala Phe Ser Leu Leu Gly Lys
    1170                1175                1180                
 Gln Asn Gln Asn Arg Glu Ile Leu Asn Ser Leu Asp Lys Glu Ala Val
1185                1190                1195                1200
 Lys Glu Asp Pro Glu Met Glu Glu Gly Leu Cys Leu Glu Val Glu Gly
                1205                1210                1215    
 Lys Met Val Ser Arg Thr Lys Gly Asp Ile Asp Asp Ser Leu Ile Gly
            1220                1225                1230        
 Gly Asp Ala Phe Thr Glu Val Ser Gln Ser Glu Asp Asn Leu Val His
        1235                1240                1245            
 Trp Glu Arg Pro Gln Arg Pro Lys Ala Pro Val Gly His Leu Tyr Gln
    1250                1255                1260                
 Thr Gln Ala Pro Ser Ala Glu Val Glu Met Thr Ser Tyr Val Leu Leu
1265                1270                1275                1280
 Ala Tyr Leu Thr Ala Gln Pro Ala Pro Thr Ser Gly Asp Leu Thr Ser
                1285                1290                1295    
 Ala Thr Asn Ile Val Lys Trp Ile Met Lys Gln Gln Asn Ala Gln Gly
            1300                1305                1310        
 Gly Phe Ser Ser Thr Gln Asp Thr Val Val Ala Leu His Ala Leu Ser
        1315                1320                1325            
 Arg Tyr Gly Ala Ala Thr Phe Thr Arg Thr Glu Lys Thr Ala Gln Val
    1330                1335                1340                
 Thr Val Gln Asp Ser Gln Thr Phe Ser Thr Asn Phe Gln Val Asp Asn
1345                1350                1355                1360
 Asn Asn Leu Leu Leu Leu Gln Gln Ile Ser Leu Pro Glu Leu Pro Gly
                1365                1370                1375    
 Glu Tyr Val Ile Thr Val Thr Gly Glu Arg Cys Val Tyr Leu Gln Thr
            1380                1385                1390        
 Ser Met Lys Tyr Asn Ile Leu Pro Glu Lys Glu Asp Ser Pro Phe Ala
        1395                1400                1405            
 Leu Lys Val Gln Thr Val Pro Gln Thr Cys Asp Gly His Lys Ala His
    1410                1415                1420                
 Thr Ser Phe Gln Ile Ser Leu Thr Ile Ser Tyr Thr Gly Asn Arg Pro
1425                1430                1435                1440
 Ala Ser Asn Met Val Ile Val Asp Val Lys Met Val Ser Gly Phe Ile
                1445                1450                1455    
 Pro Leu Lys Pro Thr Val Lys Met Leu Glu Arg Ser Ser Ser Val Ser
            1460                1465                1470        
 Arg Thr Glu Val Ser Asn Asn His Val Leu Ile Tyr Val Glu Gln Val
        1475                1480                1485            
 Thr Asn Gln Thr Leu Ser Phe Ser Phe Met Val Leu Gln Asp Ile Pro
    1490                1495                1500                
 Val Gly Asp Leu Lys Pro Ala Ile Val Lys Val Tyr Asp Tyr Tyr Glu
1505                1510                1515                1520
 Thr Asp Glu Ser Val Val Ala Glu Tyr Ile Ala Pro Cys Ser Thr Asp
                1525                1530                1535    
 Thr Glu His Gly Asn Val
            1540        

      <210> 3057
      <211> 360
      <212> PRT
      <213> Homo sapiens

      <220>
      <221> misc_feature
      <222> (1)...(360)
      <223> Xaa = any amino acid or symbol as shown in the table 8 as set forth in Example 2


      <400> 3057
 Val Ala Glu Phe Ala Ala Met Glu Pro Gly Arg Thr Gln Ile Lys Leu
   1               5                  10                  15    
 Asp Pro Arg Tyr Thr Ala Asp Leu Leu Glu Val Leu Lys Thr Asn Tyr
              20                  25                  30        
 Gly Ile Pro Ser Ala Cys Phe Ser Gln Pro Pro Thr Ala Ala Gln Leu
          35                  40                  45            
 Leu Arg Ala Leu Gly Pro Val Glu Leu Ala Leu Thr Ser Ile Leu Thr
      50                  55                  60                
 Leu Leu Ala Leu Gly Ser Ile Ala Ile Phe Leu Glu Asp Ala Val Tyr
  65                  70                  75                  80
 Leu Tyr Lys Asn Thr Leu Cys Pro Ile Lys Arg Arg Thr Leu Leu Trp
                  85                  90                  95    
 Lys Ser Ser Ala Pro Thr Val Val Ser Val Leu Cys Cys Phe Gly Leu
             100                 105                 110        
 Trp Ile Pro Arg Ser Leu Val Leu Val Glu Met Thr Ile Thr Ser Phe
         115                 120                 125            
 Tyr Ala Val Cys Phe Tyr Leu Leu Met Leu Val Met Val Glu Gly Phe
     130                 135                 140                
 Gly Gly Lys Glu Ala Val Leu Arg Thr Leu Arg Asp Thr Pro Met Met
 145                 150                 155                 160
 Val His Thr Gly Pro Cys Cys Cys Cys Cys Pro Cys Cys Pro Arg Leu
                 165                 170                 175    
 Leu Leu Thr Arg Lys Lys Leu Gln Arg Xaa Cys Trp Ala Leu Ser Asn
             180                 185                 190        
 Thr Pro Ser Xaa Arg Xaa Arg Xaa Pro Trp Trp Ala Cys Phe Ser Ser
         195                 200                 205            
 Pro Thr Ala Ser Met Thr Gln Gln Thr Phe Leu Arg Gly Ala Gln Leu
     210                 215                 220                
 Tyr Gly Ser Thr Leu Ser Ser Ala Cys Ser Thr Leu Leu Ala Leu Trp
 225                 230                 235                 240
 Thr Leu Gly Ile Ile Ser Arg Gln Ala Arg Leu His Leu Gly Glu Gln
                 245                 250                 255    
 Asn Met Gly Ala Lys Phe Ala Leu Phe Gln Val Leu Leu Ile Leu Thr
             260                 265                 270        
 Ala Leu Gln Pro Ser Ile Phe Ser Val Leu Ala Asn Gly Gly Gln Ile
         275                 280                 285            
 Ala Cys Ser Pro Pro Tyr Ser Ser Lys Thr Arg Ser Gln Val Met Asn
     290                 295                 300                
 Cys His Leu Leu Ile Leu Glu Thr Phe Leu Met Thr Val Leu Thr Arg
 305                 310                 315                 320
 Met Tyr Tyr Arg Arg Lys Asp His Lys Val Gly Tyr Glu Thr Phe Ser
                 325                 330                 335    
 Ser Pro Asp Leu Asp Leu Asn Leu Lys Ala Leu Arg Trp Met Ala Trp
             340                 345                 350        
 Thr Met Lys Gly Cys Cys Thr His
         355                 360



      <210> 3058
      <211> 138
      <212> PRT
      <213> Homo sapiens


      <400> 3058
 Phe Lys Asp Thr Ala Asn Val Phe Val Ser Leu Phe Gln Met Arg Asn
   1               5                  10                  15    
 Asn Phe Arg His Tyr Phe Ile Glu Pro Ser Gln Leu Lys Leu Phe Tyr
              20                  25                  30        
 Asp Val Ile Thr Trp Ile Val Thr Gln Val Ala Ile Ser Tyr Thr Val
          35                  40                  45            
 Val Pro Phe Val Leu Leu Ser Ile Lys Pro Ser Leu Thr Phe Tyr Ser
      50                  55                  60                
 Ser Trp Tyr Tyr Cys Leu His Ile Leu Gly Ile Leu Val Leu Leu Leu
  65                  70                  75                  80
 Leu Pro Val Lys Lys Thr Gln Arg Arg Lys Asn Thr His Glu Asn Ile
                  85                  90                  95    
 Gln Leu Ser Gln Ser Lys Lys Phe Asp Glu Gly Glu Asn Ser Leu Gly
             100                 105                 110        
 Gln Asn Ser Phe Ser Thr Thr Asn Asn Val Cys Asn Gln Asn Gln Glu
         115                 120                 125            
 Ile Ala Ser Arg His Ser Ser Leu Lys Gln
     130                 135            



      <210> 3059
      <211> 112
      <212> PRT
      <213> Homo sapiens


      <400> 3059
 Arg Ala Ser Cys Gln Gln His Pro Pro Ser Gly Pro Pro Pro Gly Pro
   1               5                  10                  15    
 Gln Arg Pro Pro Gly Arg Ser Asn Pro Gln Pro Pro Ile Gln Pro Pro
              20                  25                  30        
 Pro Leu Gly Ala Pro Pro Ala Gly Gly Gln Tyr Arg Pro Leu Gln Pro
          35                  40                  45            
 Gln Met Pro Gln Pro Arg Pro Arg Leu Gly Ser Asp Thr Gln Pro Gly
      50                  55                  60                
 Arg Pro Ala Pro Pro Pro Asn Thr Arg Gln Trp Arg Val Leu Gln Pro
  65                  70                  75                  80
 Ala Pro Pro Ala Ala Val Pro Pro Pro Gln Pro Leu Leu Gln Pro Pro
                  85                  90                  95    
 Ala Arg Leu Pro Pro Lys Pro Arg Gln Ala Trp Pro Gln Ser Pro Pro
             100                 105                 110        





      <210> 3060
      <211> 43
      <212> PRT
      <213> Homo sapiens


      <400> 3060
 Thr Cys Val Val Asn Pro Phe Leu Ser His Val Thr Leu Gln Arg Gly
   1               5                  10                  15    
 Leu Pro Ala Lys Leu Val His Leu Ile Tyr Asn Gly Ser Pro Arg Ala
              20                  25                  30        
 Ile Ser His Thr Leu Leu Phe His Phe Ser Ala
          35                  40            



      <210> 3061
      <211> 353
      <212> PRT
      <213> Homo sapiens

      <220>
      <221> misc_feature
      <222> (1)...(353)
      <223> Xaa = any amino acid or symbol as shown in the table 8 as set forth in Example 2


      <400> 3061
 Ala Cys Lys Ser Leu Pro Val Thr Ala Ala Ala Ala Ala Ala Pro Asp
   1               5                  10                  15    
 Thr Cys Gly Gly Gly Gly Val Pro Ala Ala Gly Ala Glu Met Trp Pro
              20                  25                  30        
 Leu Val Ala Ala Leu Leu Leu Gly Ser Ala Cys Cys Gly Ser Ala Gln
          35                  40                  45            
 Leu Leu Phe Asn Lys Thr Lys Ser Val Glu Phe Thr Phe Cys Asn Asp
      50                  55                  60                
 Thr Val Val Ile Pro Cys Phe Val Thr Asn Met Glu Ala Gln Asn Thr
  65                  70                  75                  80
 Thr Glu Val Tyr Val Lys Trp Lys Phe Lys Gly Arg Asp Ile Tyr Thr
                  85                  90                  95    
 Phe Asp Gly Ala Leu Asn Lys Ser Thr Val Pro Thr Asp Phe Ser Ser
             100                 105                 110        
 Ala Lys Ile Glu Val Ser Gln Leu Leu Lys Gly Asp Ala Ser Leu Lys
         115                 120                 125            
 Met Asp Lys Ser Asp Ala Val Ser His Thr Gly Asn Tyr Thr Cys Glu
     130                 135                 140                
 Val Thr Glu Leu Thr Arg Glu Gly Glu Thr Ile Ile Glu Leu Lys Tyr
 145                 150                 155                 160
 Arg Val Val Ser Trp Phe Ser Pro Asn Glu Asn Ile Leu Ile Val Ile
                 165                 170                 175    
 Phe Pro Ile Phe Ala Ile Leu Leu Phe Trp Gly Gln Phe Gly Ile Lys
             180                 185                 190        
 Thr Leu Lys Tyr Arg Ser Gly Gly Met Asp Glu Lys Thr Ile Ala Leu
         195                 200                 205            
 Leu Val Ala Gly Leu Val Ile Thr Val Ile Val Ile Val Gly Ala Ile
     210                 215                 220                
 Leu Phe Val Pro Gly Glu Tyr Ser Leu Lys Asn Ala Thr Gly Leu Gly
 225                 230                 235                 240
 Leu Ile Val Thr Ser Thr Gly Ile Leu Ile Leu Leu His Tyr Tyr Val
                 245                 250                 255    
 Phe Ser Thr Ala Ile Gly Leu Thr Ser Phe Val Ile Ala Ile Leu Val
             260                 265                 270        
 Ile Gln Val Ile Ala Tyr Ile Leu Ala Val Val Gly Leu Ser Leu Cys
         275                 280                 285            
 Ile Ala Ala Cys Ile Pro Met His Gly Pro Leu Leu Ile Ser Gly Leu
     290                 295                 300                
 Ser Ile Leu Ala Leu Ala Gln Leu Leu Gly Leu Val Tyr Met Lys Phe
 305                 310                 315                 320
 Val Ala Ser Asn Gln Lys Thr Ile Gln Pro Pro Arg Lys Ala Val Glu
                 325                 330                 335    
 Glu Pro Leu Asn Glu Xaa Leu Lys Xaa Ser Asp Gly Leu Arg Phe Gly
             340                 345                 350        
 Glu
    



      <210> 3062
      <211> 816
      <212> PRT
      <213> Homo sapiens

      <220>
      <221> misc_feature
      <222> (1)...(816)
      <223> Xaa = any amino acid or symbol as shown in the table 8 as set forth in Example 2


      <400> 3062
 Met Glu Pro Ala Gly Pro Ala Pro Gly Arg Leu Gly Pro Val Leu Cys
   1               5                  10                  15    
 Leu Leu Leu Ala Ala Ser Cys Ala Trp Ser Ala Ser Arg Gln Leu Pro
              20                  25                  30        
 Ala Val Gln Val Leu Arg Gly Asp Val Thr Cys Gly Ser Asp His Val
          35                  40                  45            
 Phe Leu Leu Ala Tyr Ile Lys His Leu Ala Val Ala Gly Arg Arg Ala
      50                  55                  60                
 Leu Lys Ala Thr Val His Val His Gln Arg Thr Leu Leu Arg Pro Gly
  65                  70                  75                  80
 Gly Cys Gly Ser Val Pro Gly Lys Arg Ala Val Thr Leu Ile Ser Lys
                  85                  90                  95    
 Cys Ser Asp Gly Gln Pro Ala Phe Pro Gly Ala Pro Ala Gly Asn Thr
             100                 105                 110        
 Asn Thr Phe Leu Val Cys Ser Cys Gly Phe Pro Asp Leu Gln Ser Ser
         115                 120                 125            
 Arg Gly Pro Glu Arg Ala Leu Cys Ala Phe Ile Gln Cys Leu Met Val
     130                 135                 140                
 Arg Pro Glu Glu Gln Arg Glu Lys Asn Trp Pro Gly Pro Arg Gly Arg
 145                 150                 155                 160
 Ser Met Ala Arg Pro Gly Trp Asn Ala Lys Pro Pro Val Val Gln Ala
                 165                 170                 175    
 Lys Ala Phe Lys Asn Trp Ala Val Leu Glu Leu Ser Thr Val Ser Ala
             180                 185                 190        
 Arg Asn Leu Thr Gly Ser Arg Ile Pro Arg Glu Asn Thr Lys Val Ile
         195                 200                 205            
 Leu Ile Gly Thr Ile Trp Val Leu Cys Phe Leu Gly Ser Ala Leu Gly
     210                 215                 220                
 Val Cys Asp Pro Gly Gly Thr His Ser His Leu Ala Met His Val Val
 225                 230                 235                 240
 Ile Phe Gly Pro Val Gly Ser Asn Asn Pro Ser Ile Val Ile Ile Ile
                 245                 250                 255    
 Ile Ile Ile Arg Pro Ile Leu Gln Ile Lys Ser Gln Arg Ser Arg Val
             260                 265                 270        
 Gly Glu Thr Phe Pro Gly Val Ser Trp Val Ala Glu Leu Glu Ser Lys
         275                 280                 285            
 Ser Lys His Thr Phe Ser Gln Cys Gln Ala Leu Leu Gln Pro Trp Gly
     290                 295                 300                
 Arg Lys Leu Ser Ser Cys Ser Gln Arg Thr Tyr Asn Leu Leu Leu Val
 305                 310                 315                 320
 Cys Ile Gln Ser Met Asn Val Ile Asp Lys His Leu Arg Lys His Arg
                 325                 330                 335    
 Gly Ser Arg Val Ala Gly Glu Glu Glu Leu Gln Val Ile Gln Pro Asp
             340                 345                 350        
 Lys Ser Val Leu Val Ala Ala Gly Glu Thr Ala Thr Leu Arg Cys Thr
         355                 360                 365            
 Ala Thr Ser Leu Ile Pro Val Gly Pro Ile Gln Trp Phe Arg Gly Ala
     370                 375                 380                
 Gly Pro Gly Arg Glu Leu Ile Tyr Asn Gln Lys Glu Gly His Phe Pro
 385                 390                 395                 400
 Arg Val Thr Thr Val Ser Asp Leu Thr Lys Arg Asn Asn Met Asp Phe
                 405                 410                 415    
 Ser Ile Arg Ile Gly Asn Ile Thr Pro Ala Asp Ala Gly Thr Tyr Tyr
             420                 425                 430        
 Cys Val Lys Phe Arg Lys Gly Ser Pro Asp Asp Val Glu Phe Lys Ser
         435                 440                 445            
 Gly Ala Gly Thr Glu Leu Ser Val Arg Ala Lys Pro Ser Ala Pro Val
     450                 455                 460                
 Val Ser Gly Pro Ala Ala Arg Ala Thr Pro Gln His Thr Val Ser Phe
 465                 470                 475                 480
 Thr Cys Glu Ser His Gly Phe Ser Pro Arg Asp Ile Thr Leu Lys Trp
                 485                 490                 495    
 Phe Lys Asn Gly Asn Glu Leu Ser Asp Phe Gln Thr Asn Val Asp Pro
             500                 505                 510        
 Val Gly Glu Ser Val Ser Tyr Ser Ile His Ser Thr Ala Lys Val Val
         515                 520                 525            
 Leu Thr Arg Glu Asp Val Asn Ser Gln Ser Phe Trp Xaa Gly Pro Thr
     530                 535                 540                
 Val Thr Leu Gln Gly Asp Pro Leu Arg Gly Thr Ala Asn Leu Ser Glu
 545                 550                 555                 560
 Thr Ile Arg Val Pro Pro Thr Leu Glu Val Ile Gln Gln Pro Val Arg
                 565                 570                 575    
 Ala Glu Asn Gln Val Asn Val Thr Cys Gln Val Arg Lys Phe Tyr Pro
             580                 585                 590        
 Gln Arg Leu Gln Leu Thr Trp Leu Glu Asn Gly Asn Val Ser Arg Thr
         595                 600                 605            
 Glu Thr Ala Ser Thr Val Thr Glu Asn Lys Asp Gly Thr Tyr Asn Trp
     610                 615                 620                
 Met Ser Trp Leu Leu Val Asn Val Ser Ala His Arg Asp Asp Val Lys
 625                 630                 635                 640
 Leu Thr Cys Gln Val Glu His Asp Gly Gln Pro Ala Val Ser Lys Ser
                 645                 650                 655    
 His Asp Leu Lys Val Ser Ala His Pro Lys Glu Gln Gly Ser Asn Thr
             660                 665                 670        
 Ala Ala Glu Asn Thr Gly Ser Asn Glu Arg Asn Ile Tyr Ile Val Val
         675                 680                 685            
 Gly Val Val Cys Thr Leu Leu Val Ala Leu Leu Met Ala Ala Leu Tyr
     690                 695                 700                
 Leu Val Arg Ile Arg Gln Lys Lys Ala Gln Gly Ser Thr Ser Ser Thr
 705                 710                 715                 720
 Arg Leu His Glu Pro Glu Lys Asn Ala Arg Glu Ile Thr Gln Asp Thr
                 725                 730                 735    
 Asn Asp Ile Thr Tyr Ala Asp Leu Asn Leu Pro Lys Gly Lys Lys Pro
             740                 745                 750        
 Ala Pro Gln Ala Ala Glu Pro Asn Asn His Thr Glu Tyr Ala Ser Ile
         755                 760                 765            
 Gln Thr Ser Pro Gln Pro Ala Ser Glu Asp Thr Leu Thr Tyr Ala Asp
     770                 775                 780                
 Leu Asp Met Val His Leu Asn Arg Thr Pro Lys Gln Pro Ala Pro Lys
 785                 790                 795                 800
 Pro Glu Pro Ser Phe Ser Glu Tyr Ala Ser Val Gln Val Pro Lys Lys
                 805                 810                 815    





      <210> 3063
      <211> 177
      <212> PRT
      <213> Homo sapiens


      <400> 3063
 Met Ser Glu Ala Gly Gly Arg Gly Cys Gly Ser Pro Val Pro Gln Arg
   1               5                  10                  15    
 Ala Arg Trp Arg Leu Val Ala Ala Thr Ala Ala Phe Cys Leu Val Ser
              20                  25                  30        
 Ala Thr Ser Val Trp Thr Ala Gly Ala Glu Pro Met Ser Arg Glu Glu
          35                  40                  45            
 Lys Gln Lys Leu Gly Asn Gln Val Leu Glu Met Phe Asp His Ala Tyr
      50                  55                  60                
 Gly Asn Tyr Met Glu His Ala Tyr Pro Ala Asp Glu Leu Met Pro Leu
  65                  70                  75                  80
 Thr Cys Arg Gly Arg Val Arg Gly Gln Glu Pro Ser Arg Gly Asp Val
                  85                  90                  95    
 Asp Asp Ala Leu Gly Lys Phe Ser Leu Thr Leu Ile Asp Ser Leu Asp
             100                 105                 110        
 Thr Leu Val Val Gly Leu Thr Leu Leu Gly Phe Ile Leu Phe Met Ile
         115                 120                 125            
 Cys Thr Leu Lys Tyr Tyr Glu Tyr Asp His Asn Thr Val Leu Asn Lys
     130                 135                 140                
 Thr Lys Glu Phe Glu Asp Ala Val Arg Lys Val Leu Arg Asp Val Asn
 145                 150                 155                 160
 Leu Asp Asn Asp Val Val Val Ser Val Phe Glu Thr Asn Ile Arg Val
                 165                 170                 175    
 Leu
    



      <210> 3064
      <211> 162
      <212> PRT
      <213> Homo sapiens


      <400> 3064
 Met Ala Gly Leu Ser Arg Gln Leu Cys Ala Leu Ser His Pro Lys Lys
   1               5                  10                  15    
 Ala Ala Glu Thr Gln Thr Ala Glu Pro Gly Gly Ala His Ala Val Cys
              20                  25                  30        
 Ser Arg His Pro Val Arg Val Lys Gly Leu Glu Gly Ser Glu Met Glu
          35                  40                  45            
 Ser Ala Arg Glu Asn Ile Asp Leu Gln Pro Gly Ser Ser Asp Pro Arg
      50                  55                  60                
 Ser Gln Pro Ile Asn Leu Asn His Tyr Ala Thr Lys Lys Ser Val Ala
  65                  70                  75                  80
 Glu Ser Met Leu Asp Val Ala Leu Phe Met Ser Asn Ala Met Arg Leu
                  85                  90                  95    
 Lys Ala Val Leu Glu Gln Gly Pro Ser Ser His Tyr Tyr Thr Thr Leu
             100                 105                 110        
 Val Thr Leu Ile Ser Leu Ser Leu Leu Leu Gln Gly Val Ile Gly Val
         115                 120                 125            
 Leu Leu Val Val Ile Ala Arg Leu Asn Leu Asn Glu Val Glu Lys Gln
     130                 135                 140                
 Trp Arg Leu Asn Gln Leu Asn Asn Ala Ala Thr Ile Leu Val Phe Phe
 145                 150                 155                 160
 Thr Glu
        



      <210> 3065
      <211> 212
      <212> PRT
      <213> Homo sapiens


      <400> 3065
 Glu Met Ser Glu Arg Trp Lys Arg Arg Gly Asn Ser Thr Arg Thr Ser
   1               5                  10                  15    
 Ser Leu Ala Ser Gly Ala Gly Asp Pro Glu Pro Asp Leu Trp Ile Ile
              20                  25                  30        
 Gln Pro Gln Glu Leu Val Leu Gly Thr Thr Gly Asp Thr Val Phe Leu
          35                  40                  45            
 Asn Cys Thr Val Leu Gly Asp Gly Pro Pro Gly Pro Ile Arg Trp Phe
      50                  55                  60                
 Gln Gly Ala Gly Leu Ser Arg Glu Ala Ile Tyr Asn Phe Gly Gly Ile
  65                  70                  75                  80
 Ser His Pro Lys Ala Thr Ala Val Gln Ala Ser Asn Asn Asp Phe Ser
                  85                  90                  95    
 Ile Leu Leu Gln Asn Val Ser Ser Glu Asp Ala Gly Thr Tyr Tyr Cys
             100                 105                 110        
 Val Lys Phe Gln Arg Lys Pro Asn Arg Gln Tyr Leu Ser Gly Gln Gly
         115                 120                 125            
 Thr Ser Leu Lys Val Lys Ala Lys Ser Thr Ser Ser Lys Glu Ala Glu
     130                 135                 140                
 Phe Thr Ser Glu Pro Ala Thr Glu Met Ser Pro Thr Gly Leu Leu Val
 145                 150                 155                 160
 Val Phe Ala Pro Val Val Leu Gly Leu Lys Ala Ile Thr Leu Ala Ala
                 165                 170                 175    
 Leu Leu Leu Ala Leu Ala Thr Ser Arg Arg Ser Pro Gly Gln Glu Asp
             180                 185                 190        
 Val Lys Thr Thr Gly Pro Ala Gly Ala Met Asn Thr Leu Ser Trp Ser
         195                 200                 205            
 Lys Gly Gln Glu
     210        



      <210> 3066
      <211> 124
      <212> PRT
      <213> Homo sapiens


      <400> 3066
 Asp Ser Arg Ile Pro Lys Glu Ala Pro Asp Gln Gln Lys Lys Lys Met
   1               5                  10                  15    
 Gly Pro Pro Ser Leu Val Leu Cys Leu Leu Ser Ala Thr Val Phe Ser
              20                  25                  30        
 Leu Leu Gly Gly Ser Ser Ala Phe Leu Ser His His Arg Leu Lys Gly
          35                  40                  45            
 Arg Phe Gln Arg Asp Arg Arg Asn Ile Arg Pro Asn Ile Ile Leu Val
      50                  55                  60                
 Leu Thr Asp Asp Gln Asp Val Glu Leu Gly Ser Met Gln Val Met Asn
  65                  70                  75                  80
 Lys Thr Arg Arg Ile Met Glu Gln Gly Gly Ala His Phe Ile Asn Ala
                  85                  90                  95    
 Phe Val Thr Thr Pro Met Cys Cys Pro Ser Arg Ser Ser Ile Leu Thr
             100                 105                 110        
 Gly Lys Tyr Val His Asn His Asn Thr Tyr Met Tyr
         115                 120                



      <210> 3067
      <211> 153
      <212> PRT
      <213> Homo sapiens


      <400> 3067
 Asp Asn His Pro Ser Phe Pro Arg Leu Pro Ser Ser Arg Pro Gly Thr
   1               5                  10                  15    
 Lys Glu Val Leu Lys Glu Ile His Ile Ser Asp Thr Thr Ala Asp Val
              20                  25                  30        
 Ile Phe Tyr Pro Ile Tyr Arg Met Ser Glu Met Ile Phe Arg Arg Ile
          35                  40                  45            
 Lys Met Pro Trp Leu Trp Leu Asp Leu Trp Tyr Leu Met Phe Lys Glu
      50                  55                  60                
 Gly Trp Glu His Lys Lys Ser Leu Lys Ile Leu His Thr Phe Thr Asn
  65                  70                  75                  80
 Ser Val Ile Ala Glu Arg Ala Asn Glu Met Asn Ala Asn Glu Asp Cys
                  85                  90                  95    
 Arg Gly Asp Gly Arg Gly Ser Ala Pro Ser Lys Asn Lys Arg Arg Ala
             100                 105                 110        
 Phe Leu Asp Leu Leu Leu Ser Val Thr Asp Asp Glu Gly Asn Arg Leu
         115                 120                 125            
 Ser His Glu Asp Ile Arg Glu Glu Val Asp Thr Phe Met Phe Glu Val
     130                 135                 140                
 Leu Tyr Ile Val Arg Phe Arg Tyr His
 145                 150            



      <210> 3068
      <211> 149
      <212> PRT
      <213> Homo sapiens


      <400> 3068
 Thr Glu Val Leu Gly Ser Lys Gly Ile His Glu Leu Arg Ser Ser Thr
   1               5                  10                  15    
 Ser Ala Leu His His Ala Leu Glu Glu Ser Ala Ser Leu Leu Thr Met
              20                  25                  30        
 Phe Trp Arg Ala Ala Leu Pro Ser Thr His Ile Pro Val Leu Pro Gly
          35                  40                  45            
 Lys Val Gly Glu Ser Thr Glu Arg Glu Leu Leu Glu Leu Arg Thr Lys
      50                  55                  60                
 Val Ser Gln Gln Glu Gln Leu Leu Gln Ser Thr Thr Glu His Leu Lys
  65                  70                  75                  80
 Asn Ala Asn Gln Gln Lys Glu Ser Met Glu Gln Phe Ile Val Ser Gln
                  85                  90                  95    
 Leu Thr Arg Thr His Asp Val Leu Lys Lys Ala Arg Thr Asn Leu Glu
             100                 105                 110        
 Val Arg Lys Leu Leu His Gln Ser Glu Ala Pro Ser Leu Ser Pro Thr
         115                 120                 125            
 His His His Pro Leu Ala Asp Leu Val Gly Asp Ser Trp Pro Ala Leu
     130                 135                 140                
 Arg Phe Gln Glu Lys
 145                



      <210> 3069
      <211> 258
      <212> PRT
      <213> Homo sapiens


      <400> 3069
 Met Val Leu Lys Val Ala Gly Pro Ala Cys Ala Ala Val Gly Leu Gly
   1               5                  10                  15    
 Ala Val Ile Leu Ala Arg Ser Arg Ala Gln Leu Gln Leu Arg Ala Gly
              20                  25                  30        
 Leu Gln Arg Gly Gln Gln Met Asp Pro Asp Arg Ala Phe Ile Cys Gly
          35                  40                  45            
 Glu Ser Arg Gln Phe Ala Gln Cys Leu Ile Phe Gly Phe Leu Phe Leu
      50                  55                  60                
 Thr Ser Gly Met Leu Ile Ser Val Leu Gly Ile Trp Val Pro Gly Cys
  65                  70                  75                  80
 Gly Ser Asn Trp Ala Gln Glu Pro Leu Asn Glu Thr Asp Thr Gly Asp
                  85                  90                  95    
 Ser Lys Pro Arg Met Cys Gly Phe Leu Ser Leu Gln Ile Met Gly Pro
             100                 105                 110        
 Leu Ile Val Leu Val Gly Leu Cys Phe Phe Val Val Ala His Val Lys
         115                 120                 125            
 Lys Arg Asn Thr Leu Asn Ala Gly Gln Asp Ala Ser Glu Arg Glu Glu
     130                 135                 140                
 Gly Gln Ile Gln Ile Met Glu Pro Val Gln Val Thr Val Ala Ala Gln
 145                 150                 155                 160
 Ser Arg Lys Gly Leu Glu Val Gly Gln Gly Gly Arg Ser His Val Lys
                 165                 170                 175    
 Ala Glu Asp Glu Arg Glu Thr Arg Pro Ala Val Ile Gln Gln Asp Leu
             180                 185                 190        
 Val Ala Leu Met Lys Pro Asp Lys Asn Val Ile Gln Met Thr Gln Ala
         195                 200                 205            
 Ser Gln Ala Arg Ile Gln Val Gln His Val Thr Gly Pro Cys Gln Trp
     210                 215                 220                
 Pro Pro Leu Pro Gly Asn Pro Glu Met Ile Asn Lys Ile Arg Lys Gly
 225                 230                 235                 240
 Pro Asp Asp Lys Ile Arg Leu Gln Arg Lys Val Val His Gly Ser Thr
                 245                 250                 255    
 Trp Met
        



      <210> 3070
      <211> 135
      <212> PRT
      <213> Homo sapiens


      <400> 3070
 Arg Thr Arg Gly Glu Glu Thr Tyr Ala Asn Phe Ile Lys His Asn Asp
   1               5                  10                  15    
 Gly Lys Asn Ile Phe Tyr Ala Ala Arg Thr Pro Ala Thr Leu Phe Ala
              20                  25                  30        
 Val Met Phe Ala Met Tyr Ile Ile Ser Gly Leu Thr Gly Phe Ile Gly
          35                  40                  45            
 Leu Asn Ser Ile Ala Val Leu Cys Asn Leu Val Met Gly Leu Ala Leu
      50                  55                  60                
 Ile Phe Leu Cys Thr Trp Ala Tyr Val Lys Tyr Ser Gly Glu Phe Arg
  65                  70                  75                  80
 Glu Ile Gly Thr Val Ile Asp Gln Ile Ala Glu Thr Leu Trp Glu Gln
                  85                  90                  95    
 Val Leu Lys Pro Leu Gly Asp Asn Leu Met Glu Glu Asn Ile Arg Gln
             100                 105                 110        
 Ser Val Thr Asn Ser Ile Lys Ala Gly Leu Thr Asp Gln Val Ser His
         115                 120                 125            
 His Ala Arg Leu Lys Thr Asp
     130                 135



      <210> 3071
      <211> 173
      <212> PRT
      <213> Homo sapiens


      <400> 3071
 Met His Trp Lys Met Leu Leu Leu Leu Leu Leu Tyr Tyr Asn Ala Glu
   1               5                  10                  15    
 Ala Ser Met Cys His Arg Trp Ser Arg Ala Val Leu Phe Pro Ala Ala
              20                  25                  30        
 His Arg Pro Lys Arg Ser Ser Ser Leu Pro Leu Asn Pro Val Leu Gln
          35                  40                  45            
 Thr Ser Leu Glu Glu Val Glu Leu Leu Tyr Glu Phe Leu Leu Ala Glu
      50                  55                  60                
 Leu Glu Ile Ser Pro Asp Leu Gln Ile Ser Ile Lys Asp Glu Glu Leu
  65                  70                  75                  80
 Ala Ser Leu Arg Lys Ala Ser Asp Phe Arg Thr Val Cys Asn Asn Val
                  85                  90                  95    
 Ile Pro Lys Ser Ile Pro Asp Ile Arg Arg Leu Ser Ala Ser Leu Ser
             100                 105                 110        
 Ser His Pro Gly Ile Leu Lys Lys Glu Asp Phe Glu Arg Thr Val Leu
         115                 120                 125            
 Thr Leu Ala Tyr Thr Ala Tyr Arg Thr Ala Leu Ser His Gly His Gln
     130                 135                 140                
 Lys Asp Ile Trp Ala Gln Ser Leu Val Ser Leu Phe Gln Ala Leu Arg
 145                 150                 155                 160
 His Asp Leu Met Arg Ser Ser Gln Pro Gly Val Pro Pro
                 165                 170            



      <210> 3072
      <211> 426
      <212> PRT
      <213> Homo sapiens


      <400> 3072
 Glu Glu Val Gln Phe Phe Ala Asn Thr Ser Gly Ser Phe Leu Cys Val
   1               5                  10                  15    
 Tyr Ser Leu Asn Ser Phe Asn Tyr Thr His Ser Pro Lys Ala Asp Ser
              20                  25                  30        
 Leu Cys Pro Arg Leu Pro Val Pro Pro Ser Lys Ser Phe Pro Leu Phe
          35                  40                  45            
 Asn Arg Cys Val Pro Gln Thr Pro Glu Cys Tyr Ser Leu Phe Ala Ser
      50                  55                  60                
 Val Leu Ile Asn Asp Val Asp Thr Leu His Arg Ile Leu Ser Gly Ile
  65                  70                  75                  80
 Met Ser Gly Arg Asp Thr Ile Leu Gly Leu Cys Ile Leu Ala Leu Ala
                  85                  90                  95    
 Leu Ser Leu Ala Met Met Phe Thr Phe Arg Phe Ile Thr Thr Leu Leu
             100                 105                 110        
 Val His Ile Phe Ile Ser Leu Val Ile Leu Gly Leu Leu Phe Val Cys
         115                 120                 125            
 Gly Val Leu Trp Trp Leu Tyr Tyr Asp Tyr Thr Asn Asp Leu Ser Ile
     130                 135                 140                
 Glu Leu Asp Thr Glu Arg Glu Asn Met Lys Cys Val Leu Gly Phe Ala
 145                 150                 155                 160
 Ile Val Ser Thr Gly Ile Thr Ala Val Leu Leu Val Leu Ile Phe Val
                 165                 170                 175    
 Leu Arg Lys Arg Ile Lys Leu Thr Val Glu Leu Phe Gln Ile Thr Asn
             180                 185                 190        
 Lys Ala Ile Ser Ser Ala Pro Phe Leu Leu Phe Gln Pro Leu Trp Thr
         195                 200                 205            
 Phe Ala Ile Leu Ile Phe Phe Trp Val Leu Trp Val Ala Val Leu Leu
     210                 215                 220                
 Ser Leu Gly Thr Ala Gly Ala Ala Gln Val Met Glu Gly Gly Gln Val
 225                 230                 235                 240
 Glu Tyr Lys Pro Leu Ser Gly Ile Arg Tyr Met Trp Ser Tyr His Leu
                 245                 250                 255    
 Ile Gly Leu Ile Trp Thr Ser Glu Phe Ile Leu Ala Cys Gln Gln Met
             260                 265                 270        
 Thr Ile Ala Gly Ala Val Val Thr Cys Tyr Phe Asn Arg Ser Lys Asn
         275                 280                 285            
 Asp Pro Pro Asp His Pro Ile Leu Ser Ser Leu Ser Ile Leu Phe Phe
     290                 295                 300                
 Tyr His Gln Gly Thr Ile Val Lys Gly Ser Phe Leu Ile Ser Val Val
 305                 310                 315                 320
 Arg Ile Pro Arg Ile Ile Val Met Tyr Met Gln Asn Ala Leu Lys Glu
                 325                 330                 335    
 Gln His Gly Ala Leu Ser Arg Tyr Leu Phe Arg Cys Cys Tyr Cys Cys
             340                 345                 350        
 Phe Trp Gly Leu Asp Lys Tyr Leu Leu His Leu Asn Gln Asn Ala Tyr
         355                 360                 365            
 Thr Thr Thr Ala Ile Asn Gly Thr Asp Phe Cys Thr Ser Ala Lys Asp
     370                 375                 380                
 Ala Phe Lys Ile Leu Ser Lys Asn Ser Ser His Phe Thr Ser Ile Asn
 385                 390                 395                 400
 Cys Phe Gly Asp Phe Ile Ile Phe Leu Arg Lys Gly Leu Arg Val Cys
                 405                 410                 415    
 Phe Thr Gly Phe Gly Arg Thr Gln Cys Phe
             420                 425    



      <210> 3073
      <211> 1241
      <212> PRT
      <213> Homo sapiens


      <400> 3073
 Pro Ala Ala Pro Glu His Thr Asp Pro Ser Glu Pro Arg Gly Ser Val
   1               5                  10                  15    
 Ser Cys Cys Ser Leu Leu Arg Gly Leu Ser Ser Gly Trp Ser Ser Pro
              20                  25                  30        
 Leu Leu Pro Ala Pro Val Cys Asn Pro Asn Lys Ala Ile Phe Thr Val
          35                  40                  45            
 Asp Ala Lys Thr Thr Glu Ile Leu Val Ala Asn Asp Lys Ala Cys Gly
      50                  55                  60                
 Leu Leu Gly Tyr Ser Ser Gln Asp Leu Ile Gly Gln Lys Leu Thr Gln
  65                  70                  75                  80
 Phe Phe Leu Arg Ser Asp Ser Asp Val Val Glu Ala Leu Ser Glu Glu
                  85                  90                  95    
 His Met Glu Ala Asp Gly His Ala Ala Val Val Phe Gly Thr Val Val
             100                 105                 110        
 Asp Ile Ile Ser Arg Ser Gly Glu Lys Ile Pro Val Ser Val Trp Met
         115                 120                 125            
 Lys Arg Met Arg Gln Glu Arg Arg Leu Cys Cys Val Val Val Leu Glu
     130                 135                 140                
 Pro Val Glu Arg Val Ser Thr Trp Val Ala Phe Gln Ser Asp Gly Thr
 145                 150                 155                 160
 Val Thr Ser Cys Asp Ser Leu Phe Ala His Leu His Gly Tyr Val Ser
                 165                 170                 175    
 Gly Glu Asp Val Ala Gly Gln His Ile Thr Asp Leu Ile Pro Ser Val
             180                 185                 190        
 Gln Leu Pro Pro Ser Gly Gln His Ile Pro Lys Asn Leu Lys Ile Gln
         195                 200                 205            
 Arg Ser Val Gly Arg Ala Arg Asp Gly Thr Thr Phe Pro Leu Ser Leu
     210                 215                 220                
 Lys Leu Lys Ser Gln Pro Ser Ser Glu Glu Ala Thr Thr Gly Glu Ala
 225                 230                 235                 240
 Ala Pro Val Ser Gly Tyr Arg Ala Ser Val Trp Val Phe Cys Thr Ile
                 245                 250                 255    
 Ser Gly Leu Ile Thr Leu Leu Pro Asp Gly Thr Ile His Gly Ile Asn
             260                 265                 270        
 His Ser Phe Ala Leu Thr Leu Phe Gly Tyr Gly Lys Thr Glu Leu Leu
         275                 280                 285            
 Gly Lys Asn Ile Thr Phe Leu Ile Pro Gly Phe Tyr Ser Tyr Met Asp
     290                 295                 300                
 Leu Ala Tyr Asn Ser Ser Leu Gln Leu Pro Asp Leu Ala Ser Cys Leu
 305                 310                 315                 320
 Asp Val Gly Asn Glu Ser Gly Cys Gly Glu Arg Thr Leu Asp Pro Trp
                 325                 330                 335    
 Gln Gly Gln Asp Pro Ala Glu Gly Gly Gln Asp Pro Arg Ile Asn Val
             340                 345                 350        
 Val Leu Ala Gly Gly His Val Val Pro Arg Asp Glu Ile Arg Lys Leu
         355                 360                 365            
 Met Glu Ser Gln Asp Ile Phe Thr Gly Thr Gln Thr Glu Leu Ile Ala
     370                 375                 380                
 Gly Gly Gln Leu Leu Ser Cys Leu Ser Pro Gln Pro Ala Pro Gly Val
 385                 390                 395                 400
 Asp Asn Val Pro Glu Gly Ser Leu Pro Val His Gly Glu Gln Ala Leu
                 405                 410                 415    
 Pro Lys Asp Gln Gln Ile Thr Ala Leu Gly Arg Glu Glu Pro Val Ala
             420                 425                 430        
 Ile Glu Ser Pro Gly Gln Asp Leu Leu Gly Glu Ser Arg Ser Glu Pro
         435                 440                 445            
 Val Asp Val Lys Pro Phe Ala Ser Cys Glu Asp Ser Glu Ala Pro Val
     450                 455                 460                
 Pro Ala Glu Asp Gly Gly Ser Asp Ala Gly Met Cys Gly Leu Cys Gln
 465                 470                 475                 480
 Lys Ala Gln Leu Glu Arg Met Gly Val Ser Gly Pro Ser Gly Ser Asp
                 485                 490                 495    
 Leu Trp Ala Gly Ala Ala Val Ala Lys Pro Gln Ala Lys Gly Gln Leu
             500                 505                 510        
 Ala Gly Gly Ser Leu Leu Met His Cys Pro Cys Tyr Gly Ser Glu Trp
         515                 520                 525            
 Gly Leu Trp Trp Arg Ser Gln Asp Leu Ala Pro Ser Pro Ser Gly Met
     530                 535                 540                
 Ala Gly Leu Ser Phe Gly Thr Pro Thr Leu Asp Glu Pro Trp Leu Gly
 545                 550                 555                 560
 Val Glu Asn Asp Arg Glu Glu Leu Gln Thr Cys Leu Ile Lys Glu Gln
                 565                 570                 575    
 Leu Ser Gln Leu Ser Leu Ala Gly Ala Leu Asp Val Pro His Ala Glu
             580                 585                 590        
 Leu Val Pro Thr Glu Cys Gln Ala Val Thr Ala Pro Val Ser Ser Cys
         595                 600                 605            
 Asp Leu Gly Gly Arg Asp Leu Cys Gly Gly Cys Thr Gly Ser Ser Ser
     610                 615                 620                
 Ala Cys Tyr Ala Leu Ala Thr Asp Leu Pro Gly Gly Leu Glu Ala Val
 625                 630                 635                 640
 Glu Ala Gln Glu Val Asp Val Asn Ser Phe Ser Trp Asn Leu Lys Glu
                 645                 650                 655    
 Leu Phe Phe Ser Asp Gln Thr Asp Gln Thr Ser Ser Asn Cys Ser Cys
             660                 665                 670        
 Ala Thr Ser Glu Leu Arg Glu Thr Pro Ser Ser Leu Ala Val Gly Ser
         675                 680                 685            
 Asp Pro Asp Val Gly Ser Leu Gln Glu Gln Gly Ser Cys Val Leu Asp
     690                 695                 700                
 Asp Arg Glu Leu Leu Leu Leu Thr Gly Thr Cys Val Asp Leu Gly Gln
 705                 710                 715                 720
 Gly Arg Arg Phe Arg Glu Ser Cys Val Gly His Asp Pro Thr Glu Pro
                 725                 730                 735    
 Leu Glu Val Cys Leu Val Ser Ser Glu His Tyr Ala Ala Ser Asp Arg
             740                 745                 750        
 Glu Ser Pro Gly His Val Pro Ser Thr Leu Asp Ala Gly Pro Glu Asp
         755                 760                 765            
 Thr Cys Pro Ser Ala Glu Glu Pro Arg Leu Asn Val Gln Val Thr Ser
     770                 775                 780                
 Thr Pro Val Ile Val Met Arg Gly Ala Ala Gly Leu Gln Arg Glu Ile
 785                 790                 795                 800
 Gln Glu Gly Ala Tyr Ser Gly Ser Cys Tyr His Arg Asp Gly Leu Arg
                 805                 810                 815    
 Leu Ser Ile Gln Phe Glu Val Arg Arg Val Glu Leu Gln Gly Pro Thr
             820                 825                 830        
 Pro Leu Phe Cys Cys Trp Leu Val Lys Asp Leu Leu His Ser Gln Arg
         835                 840                 845            
 Asp Ser Ala Ala Arg Thr Arg Leu Phe Leu Ala Ser Leu Pro Gly Ser
     850                 855                 860                
 Thr His Ser Thr Ala Ala Glu Leu Thr Gly Pro Ser Leu Val Glu Val
 865                 870                 875                 880
 Leu Arg Ala Arg Pro Trp Phe Glu Glu Pro Pro Lys Ala Val Glu Leu
                 885                 890                 895    
 Glu Gly Leu Ala Ala Cys Glu Gly Glu Tyr Ser Gln Lys Tyr Ser Thr
             900                 905                 910        
 Met Ser Pro Leu Gly Ser Gly Ala Phe Gly Phe Val Trp Thr Ala Val
         915                 920                 925            
 Asp Lys Glu Lys Asn Lys Glu Val Val Val Lys Phe Ile Lys Lys Glu
     930                 935                 940                
 Lys Val Leu Glu Asp Cys Trp Ile Glu Asp Pro Lys Leu Gly Lys Val
 945                 950                 955                 960
 Thr Leu Glu Ile Ala Ile Leu Ser Arg Val Glu His Ala Asn Ile Ile
                 965                 970                 975    
 Lys Val Leu Asp Ile Phe Glu Asn Gln Gly Phe Phe Gln Leu Val Met
             980                 985                 990        
 Glu Lys His Gly Ser Gly Leu Asp Leu Phe Ala Phe Ile Asp Arg His
         995                1000                1005            
 Pro Arg Leu Asp Glu Pro Leu Ala Ser Tyr Ile Phe Arg Gln Val Arg
    1010                1015                1020                
 Ala Gly Gln Ser Arg Leu Val Ser Ala Val Gly Tyr Leu Arg Leu Lys
1025                1030                1035                1040
 Asp Ile Ile His Arg Asp Ile Lys Asp Glu Asn Ile Val Ile Ala Glu
                1045                1050                1055    
 Asp Phe Thr Ile Lys Leu Ile Asp Phe Gly Ser Ala Ala Tyr Leu Glu
            1060                1065                1070        
 Arg Gly Lys Leu Phe Tyr Thr Phe Cys Gly Thr Ile Glu Tyr Cys Ala
        1075                1080                1085            
 Pro Glu Val Leu Met Gly Asn Pro Tyr Arg Gly Pro Glu Leu Glu Met
    1090                1095                1100                
 Trp Ser Leu Gly Val Thr Leu Tyr Thr Leu Val Phe Glu Glu Asn Pro
1105                1110                1115                1120
 Phe Cys Glu Leu Glu Glu Thr Val Glu Ala Ala Ile His Pro Pro Tyr
                1125                1130                1135    
 Leu Val Ser Lys Glu Leu Met Ser Leu Val Ser Gly Leu Leu Gln Pro
            1140                1145                1150        
 Val Pro Glu Arg Arg Thr Thr Leu Glu Lys Leu Val Thr Asp Pro Trp
        1155                1160                1165            
 Val Thr Gln Pro Val Asn Leu Ala Asp Tyr Thr Trp Glu Glu Val Phe
    1170                1175                1180                
 Arg Val Asn Lys Pro Glu Ser Gly Val Leu Ser Ala Ala Ser Leu Glu
1185                1190                1195                1200
 Met Gly Asn Arg Ser Leu Ser Asp Val Ala Gln Ala Gln Glu Leu Cys
                1205                1210                1215    
 Gly Gly Pro Val Pro Gly Glu Ala Pro Asn Gly Gln Gly Cys Leu His
            1220                1225                1230        
 Pro Gly Asp Pro Arg Leu Leu Thr Ser
        1235                1240    



      <210> 3074
      <211> 86
      <212> PRT
      <213> Homo sapiens


      <400> 3074
 Val Lys Tyr Val Phe Tyr His Lys Leu Asn Phe Gln Ala Ser Phe Asp
   1               5                  10                  15    
 Leu Ala Leu Asp Gly Ser Pro Arg Leu Pro Ala Leu Val Leu Ser Ser
              20                  25                  30        
 Leu Gln Val Thr Glu Ser Glu Pro Ser Val Met Trp Leu Ser Gly Leu
          35                  40                  45            
 His Ile Pro Glu Ser Tyr Leu Thr Ala Leu Val Gln Ala Thr Cys Arg
      50                  55                  60                
 Lys Asn Gly Trp Pro Leu Asp Arg Ser Thr Leu Phe Thr Gln Val Thr
  65                  70                  75                  80
 Lys Phe Gln Asp Ala Asp
                  85    



      <210> 3075
      <211> 347
      <212> PRT
      <213> Homo sapiens


      <400> 3075
 Ala Pro Val Thr Lys Arg Lys Glu Val Phe Ala Lys Asp Ser Lys Gly
   1               5                  10                  15    
 Ser Ala Leu Asp Ala Gly Arg Asp Pro Lys Arg Pro Ala Leu Pro Glu
              20                  25                  30        
 Thr Leu Cys Glu Ser Gly Trp Ala Ser Asn Thr Ala Pro Thr Thr Pro
          35                  40                  45            
 Pro Gln Pro Gly Trp Cys Leu Cys Gly Lys Asp Phe Lys Ser Ser Cys
      50                  55                  60                
 Gln Thr Pro Gly Arg Glu Lys Glu Arg Arg Leu Ala Thr Met His Gly
  65                  70                  75                  80
 Ser Cys Ser Phe Leu Met Leu Leu Leu Pro Leu Leu Leu Leu Leu Val
                  85                  90                  95    
 Ala Thr Thr Gly Pro Val Gly Ala Leu Thr Asp Glu Glu Lys Arg Leu
             100                 105                 110        
 Met Val Glu Leu His Asn Leu Tyr Arg Ala Gln Val Ser Pro Thr Ala
         115                 120                 125            
 Ser Asp Met Leu His Met Arg Trp Asp Glu Glu Leu Ala Ala Phe Ala
     130                 135                 140                
 Lys Ala Tyr Ala Arg Gln Cys Val Trp Gly His Asn Lys Glu Arg Gly
 145                 150                 155                 160
 Arg Arg Gly Glu Asn Leu Phe Ala Ile Thr Asp Glu Gly Met Asp Val
                 165                 170                 175    
 Pro Leu Ala Met Glu Glu Trp His His Glu Arg Glu His Tyr Asn Leu
             180                 185                 190        
 Ser Ala Ala Thr Cys Ser Pro Gly Gln Met Cys Gly His Tyr Thr Gln
         195                 200                 205            
 Val Val Trp Ala Lys Thr Glu Arg Ile Gly Cys Gly Ser His Phe Cys
     210                 215                 220                
 Glu Lys Leu Gln Gly Val Glu Glu Thr Asn Ile Glu Leu Leu Val Cys
 225                 230                 235                 240
 Asn Tyr Glu Pro Pro Gly Asn Val Lys Gly Lys Arg Pro Tyr Gln Glu
                 245                 250                 255    
 Gly Thr Pro Cys Ser Gln Cys Pro Ser Gly Tyr His Cys Lys Asn Ser
             260                 265                 270        
 Leu Cys Glu Pro Ile Gly Ser Pro Glu Asp Ala Gln Asp Leu Pro Tyr
         275                 280                 285            
 Leu Val Thr Glu Ala Pro Ser Phe Arg Ala Thr Glu Ala Ser Asp Ser
     290                 295                 300                
 Arg Lys Met Gly Ala Glu Gly Pro Asp Lys Pro Ser Val Val Ser Gly
 305                 310                 315                 320
 Leu Asn Ser Gly Pro Gly His Val Trp Gly Pro Leu Leu Gly Leu Leu
                 325                 330                 335    
 Leu Leu Pro Pro Leu Val Leu Ala Gly Ile Phe
             340                 345        



      <210> 3076
      <211> 480
      <212> PRT
      <213> Homo sapiens

      <220>
      <221> misc_feature
      <222> (1)...(480)
      <223> Xaa = any amino acid or symbol as shown in the table 8 as set forth in Example 2


      <400> 3076
 Gly Ala Ala Ala Gly Ala Ala Asp Pro Arg Arg Gly Ser Leu Gly Gly
   1               5                  10                  15    
 Arg Thr Met Leu Asp Phe Ala Ile Phe Ala Val Thr Phe Leu Leu Ala
              20                  25                  30        
 Leu Val Gly Ala Val Leu Tyr Leu Tyr Pro Ala Ser Arg Gln Ala Ala
          35                  40                  45            
 Gly Ile Pro Gly Ile Thr Pro Thr Glu Glu Lys Asp Gly Asn Leu Pro
      50                  55                  60                
 Asp Ile Val Asn Ser Gly Ser Leu His Glu Phe Leu Val Asn Leu His
  65                  70                  75                  80
 Glu Arg Tyr Gly Pro Val Val Ser Phe Trp Phe Gly Arg Arg Leu Val
                  85                  90                  95    
 Val Ser Leu Gly Thr Val Asp Val Leu Lys Gln His Ile Asn Pro Asn
             100                 105                 110        
 Lys Thr Leu Asp Leu Phe Xaa Asn His Ala Glu Val Ile Ile Lys Val
         115                 120                 125            
 Ser Ile Trp Trp Trp Gln Cys Glu Xaa Lys Pro Gln Arg Lys Lys Leu
     130                 135                 140                
 Tyr Glu Asn Gly Val Thr Asp Ser Leu Lys Ser Asn Phe Ala Leu Leu
 145                 150                 155                 160
 Leu Lys Leu Pro Glu Glu Leu Leu Asp Lys Trp Leu Ser Tyr Pro Glu
                 165                 170                 175    
 Thr Gln His Val Pro Leu Ser Gln His Met Leu Gly Phe Ala Met Lys
             180                 185                 190        
 Ser Val Thr Gln Met Val Met Gly Ser Thr Phe Glu Asp Asp Gln Glu
         195                 200                 205            
 Val Ile Arg Phe Gln Lys Asn His Gly Thr Val Trp Ser Glu Ile Gly
     210                 215                 220                
 Lys Gly Phe Leu Asp Gly Ser Leu Asp Lys Asn Met Thr Arg Lys Lys
 225                 230                 235                 240
 Gln Tyr Glu Asp Ala Leu Met Gln Leu Glu Ser Val Leu Arg Asn Ile
                 245                 250                 255    
 Ile Lys Glu Arg Lys Gly Arg Asn Phe Ser Gln His Ile Phe Ile Asp
             260                 265                 270        
 Ser Leu Val Gln Gly Asn Leu Asn Asp Gln Gln Ile Leu Glu Asp Ser
         275                 280                 285            
 Met Ile Phe Ser Leu Ala Ser Cys Ile Ile Thr Ala Lys Leu Cys Thr
     290                 295                 300                
 Trp Ala Ile Trp Phe Leu Thr Thr Ser Glu Glu Val Gln Lys Lys Leu
 305                 310                 315                 320
 Tyr Glu Glu Ile Asn Gln Val Phe Gly Asn Gly Pro Val Thr Pro Glu
                 325                 330                 335    
 Lys Ile Glu Gln Leu Arg Tyr Cys Gln His Val Leu Cys Glu Thr Val
             340                 345                 350        
 Arg Thr Ala Lys Leu Thr Pro Val Ser Ala Gln Leu Gln Asp Ile Glu
         355                 360                 365            
 Gly Lys Ile Asp Arg Phe Ile Ile Pro Arg Glu Thr Leu Val Leu Tyr
     370                 375                 380                
 Ala Leu Gly Val Val Leu Gln Asp Pro Asn Thr Trp Pro Ser Pro His
 385                 390                 395                 400
 Lys Phe Asp Pro Asp Arg Phe Asp Asp Glu Leu Val Met Lys Thr Phe
                 405                 410                 415    
 Ser Ser Leu Gly Phe Ser Gly Thr Gln Glu Cys Pro Glu Leu Arg Phe
             420                 425                 430        
 Ala Tyr Met Val Thr Thr Val Leu Leu Ser Val Leu Val Lys Arg Leu
         435                 440                 445            
 His Leu Leu Ser Val Glu Gly Gln Val Ile Glu Thr Lys Tyr Glu Leu
     450                 455                 460                
 Val Thr Ser Ser Arg Glu Glu Ala Trp Ile Thr Val Ser Lys Arg Tyr
 465                 470                 475                 480





      <210> 3077
      <211> 365
      <212> PRT
      <213> Homo sapiens


      <400> 3077
 Met Ser Leu Leu Gly Phe Leu Leu Ser Arg Leu Gly Leu Leu Leu Lys
   1               5                  10                  15    
 Val Leu Leu Asp Trp Pro Val Glu Val Leu Tyr Gly Ala Ala Ala Leu
              20                  25                  30        
 Asn Gly Leu Phe Gly Gly Phe Ser Ala Phe Trp Ser Gly Val Met Ala
          35                  40                  45            
 Leu Gly Ser Leu Gly Ser Ser Glu Gly Arg Arg Ser Val Arg Leu Ile
      50                  55                  60                
 Leu Ile Asp Leu Met Leu Gly Leu Ala Gly Phe Cys Gly Ser Met Ala
  65                  70                  75                  80
 Ser Gly His Leu Phe Lys Gln Met Ala Gly His Ser Gly Gln Gly Leu
                  85                  90                  95    
 Ile Leu Thr Ala Cys Ser Val Ser Cys Ala Ser Phe Ala Leu Leu Tyr
             100                 105                 110        
 Ser Leu Leu Val Leu Lys Val Pro Glu Ser Val Ala Lys Pro Ser Gln
         115                 120                 125            
 Glu Leu Pro Ala Val Asp Thr Val Ser Gly Thr Val Gly Thr Tyr Arg
     130                 135                 140                
 Thr Leu Asp Pro Asp Gln Leu Asp Gln Gln Tyr Ala Val Gly His Pro
 145                 150                 155                 160
 Pro Ser Pro Gly Lys Ala Lys Pro His Lys Thr Thr Ile Ala Leu Leu
                 165                 170                 175    
 Phe Val Gly Ala Ile Ile Tyr Asp Leu Ala Val Val Gly Thr Val Asp
             180                 185                 190        
 Val Ile Pro Leu Phe Val Leu Arg Glu Pro Leu Gly Trp Asn Gln Val
         195                 200                 205            
 Gln Val Gly Tyr Gly Met Ala Ala Gly Tyr Thr Ile Phe Ile Thr Ser
     210                 215                 220                
 Phe Leu Gly Val Leu Val Phe Ser Arg Cys Phe Arg Asp Thr Thr Met
 225                 230                 235                 240
 Ile Met Ile Gly Met Val Ser Phe Gly Ser Gly Ala Leu Leu Leu Ala
                 245                 250                 255    
 Phe Val Lys Glu Thr Tyr Met Phe Tyr Ile Ala Arg Ala Val Met Leu
             260                 265                 270        
 Phe Ala Leu Ile Pro Val Thr Thr Ile Arg Ser Ala Met Ser Lys Leu
         275                 280                 285            
 Ile Lys Gly Ser Ser Tyr Gly Lys Val Phe Val Ile Leu Gln Leu Ser
     290                 295                 300                
 Leu Ala Leu Thr Gly Val Val Thr Ser Thr Leu Tyr Asn Lys Ile Tyr
 305                 310                 315                 320
 Gln Leu Thr Met Asp Met Phe Gly Gly Ser Cys Phe Ala Leu Ser Ser
                 325                 330                 335    
 Phe Leu Ser Phe Leu Ala Ile Ile Pro Ile Ser Ile Val Ala Tyr Lys
             340                 345                 350        
 Gln Val Pro Leu Ser Pro Tyr Gly Asp Ile Ile Glu Lys
         355                 360                 365



      <210> 3078
      <211> 270
      <212> PRT
      <213> Homo sapiens


      <400> 3078
 Gly Arg Thr Ser Ser Gly Lys Ala Gly Met Trp Lys Pro Gly Ala Glu
   1               5                  10                  15    
 Ser Trp Pro Leu His Thr Gly Ala Ala Gln Val Met Trp Phe Glu Lys
              20                  25                  30        
 Leu Tyr Ala Gly Leu Gln Cys Val Glu Lys Tyr Leu Ile Tyr Pro Ala
          35                  40                  45            
 Val Val Leu Asn Ala Leu Thr Val Asp Ala His Thr Val Val Ser His
      50                  55                  60                
 Pro Asp Lys Tyr Cys Phe Tyr Cys Arg Ala Leu Leu Met Thr Val Ala
  65                  70                  75                  80
 Gly Leu Lys Leu Leu Arg Ser Ala Phe Cys Cys Pro Pro Gln Gln Tyr
                  85                  90                  95    
 Leu Thr Leu Ala Phe Thr Val Leu Leu Phe His Phe Asp Tyr Pro Arg
             100                 105                 110        
 Leu Ser Gln Gly Phe Leu Leu Asp Tyr Phe Leu Met Ser Leu Leu Cys
         115                 120                 125            
 Ser Lys Leu Trp Asp Leu Leu Tyr Lys Leu Arg Phe Val Leu Thr Tyr
     130                 135                 140                
 Ile Ala Pro Trp Gln Ile Thr Trp Gly Ser Ala Phe His Ala Phe Ala
 145                 150                 155                 160
 Gln Pro Phe Ala Val Pro His Ser Ala Met Leu Phe Val Gln Ala Leu
                 165                 170                 175    
 Leu Ser Gly Leu Phe Ser Thr Pro Leu Asn Pro Leu Leu Gly Ser Ala
             180                 185                 190        
 Val Phe Ile Met Ser Tyr Ala Arg Pro Leu Lys Phe Trp Glu Arg Asp
         195                 200                 205            
 Tyr Asn Thr Lys Arg Val Asp His Ser Asn Thr Arg Leu Val Thr Gln
     210                 215                 220                
 Leu Asp Arg Asn Pro Gly Ala Asp Asp Asn Asn Leu Asn Ser Ile Phe
 225                 230                 235                 240
 Tyr Glu His Leu Thr Arg Ser Leu Gln His Thr Leu Cys Gly Asp Leu
                 245                 250                 255    
 Val Leu Gly Arg Trp Gly Asn Tyr Gly Pro Gly Asp Cys Phe
             260                 265                 270



      <210> 3079
      <211> 48
      <212> PRT
      <213> Homo sapiens


      <400> 3079
 Asn Ile Ser Gly Ser Asp Glu Glu Gln Ala Arg Arg Val Leu Glu Glu
   1               5                  10                  15    
 Tyr Ile Pro Gly Ala Leu Leu Ser Asp Ser Ala Gln Arg Ser Ala Tyr
              20                  25                  30        
 Ala Gly Arg Thr Asp Gly Ala Ser Ala Ala Ala Phe Ile Lys Pro Pro
          35                  40                  45            





      <210> 3080
      <211> 1508
      <212> PRT
      <213> Homo sapiens


      <400> 3080
 Gly Arg Ala Gly Leu Gly Trp Ser Ser Gly Gly Arg Gly Ser Arg Ala
   1               5                  10                  15    
 Cys Ser Glu Gly Pro Ala Glu Ala Arg Gly Arg Glu Gly Asp Lys Gly
              20                  25                  30        
 Ser Ala Ala Leu Ser Pro Pro Leu Pro Leu Thr Leu Gly Glu Glu Met
          35                  40                  45            
 Ala Ala Glu Arg Gly Ala Arg Arg Leu Leu Ser Thr Pro Ser Phe Trp
      50                  55                  60                
 Leu Tyr Cys Leu Leu Leu Leu Gly Arg Arg Ala Pro Gly Ala Ala Ala
  65                  70                  75                  80
 Ala Arg Ser Gly Ser Ala Pro Gln Ser Pro Gly Ala Ser Ile Arg Thr
                  85                  90                  95    
 Phe Thr Pro Phe Tyr Phe Leu Val Glu Pro Val Asp Thr Leu Ser Val
             100                 105                 110        
 Arg Gly Ser Ser Val Ile Leu Asn Cys Ser Ala Tyr Ser Glu Pro Ser
         115                 120                 125            
 Pro Lys Ile Glu Trp Lys Lys Asp Gly Thr Phe Leu Asn Leu Val Ser
     130                 135                 140                
 Asp Asp Arg Arg Gln Leu Leu Pro Asp Gly Ser Leu Phe Ile Ser Asn
 145                 150                 155                 160
 Val Val His Ser Lys His Asn Lys Pro Asp Glu Gly Tyr Tyr Gln Cys
                 165                 170                 175    
 Val Ala Thr Val Glu Ser Leu Gly Thr Ile Ile Ser Arg Thr Ala Lys
             180                 185                 190        
 Leu Ile Val Ala Gly Leu Pro Arg Phe Thr Ser Gln Pro Glu Pro Ser
         195                 200                 205            
 Ser Val Tyr Ala Gly Asn Asn Ala Ile Leu Asn Cys Glu Val Asn Ala
     210                 215                 220                
 Asp Leu Val Pro Phe Val Arg Trp Glu Gln Asn Arg Gln Pro Leu Leu
 225                 230                 235                 240
 Leu Asp Asp Arg Val Ile Lys Leu Pro Ser Gly Met Leu Val Ile Ser
                 245                 250                 255    
 Asn Ala Thr Glu Gly Asp Gly Gly Leu Tyr Arg Cys Val Val Glu Ser
             260                 265                 270        
 Gly Gly Pro Pro Lys Tyr Ser Asp Glu Val Glu Leu Lys Val Leu Pro
         275                 280                 285            
 Asp Pro Glu Val Ile Ser Asp Leu Val Phe Leu Lys Gln Pro Ser Pro
     290                 295                 300                
 Leu Val Arg Val Ile Gly Gln Asp Val Val Leu Pro Cys Val Ala Ser
 305                 310                 315                 320
 Gly Leu Pro Thr Pro Thr Ile Lys Trp Met Lys Asn Glu Glu Ala Leu
                 325                 330                 335    
 Asp Thr Glu Ser Ser Glu Arg Leu Val Leu Leu Ala Gly Gly Ser Leu
             340                 345                 350        
 Glu Ile Ser Asp Val Thr Glu Asp Asp Ala Gly Thr Tyr Phe Cys Ile
         355                 360                 365            
 Ala Asp Asn Gly Asn Glu Thr Ile Glu Ala Gln Ala Glu Leu Thr Val
     370                 375                 380                
 Gln Ala Gln Pro Glu Phe Leu Lys Gln Pro Thr Asn Ile Tyr Ala His
 385                 390                 395                 400
 Glu Ser Met Asp Ile Val Phe Glu Cys Glu Val Thr Gly Lys Pro Thr
                 405                 410                 415    
 Pro Thr Val Lys Trp Val Lys Asn Gly Asp Met Val Ile Pro Ser Asp
             420                 425                 430        
 Tyr Phe Lys Ile Val Lys Glu His Asn Leu Gln Val Leu Gly Leu Val
         435                 440                 445            
 Lys Ser Asp Glu Gly Phe Tyr Gln Cys Ile Ala Glu Asn Asp Val Gly
     450                 455                 460                
 Asn Ala Gln Ala Gly Ala Gln Leu Ile Ile Leu Glu His Ala Pro Ala
 465                 470                 475                 480
 Thr Thr Gly Pro Leu Pro Ser Ala Pro Arg Asp Val Val Ala Ser Leu
                 485                 490                 495    
 Val Ser Thr Arg Phe Ile Lys Leu Thr Trp Arg Thr Pro Ala Ser Asp
             500                 505                 510        
 Pro His Gly Asp Asn Leu Thr Tyr Ser Val Phe Tyr Thr Lys Glu Gly
         515                 520                 525            
 Ile Ala Arg Glu Arg Val Glu Asn Thr Ser His Pro Gly Glu Met Gln
     530                 535                 540                
 Val Thr Ile Gln Asn Leu Met Pro Ala Thr Val Tyr Ile Phe Arg Val
 545                 550                 555                 560
 Met Ala Gln Asn Lys His Gly Ser Gly Glu Ser Ser Ala Pro Leu Arg
                 565                 570                 575    
 Val Glu Thr Gln Pro Glu Val Gln Leu Pro Gly Pro Ala Pro Asn Leu
             580                 585                 590        
 Arg Ala Tyr Ala Ala Ser Pro Thr Ser Ile Thr Val Thr Trp Glu Thr
         595                 600                 605            
 Pro Val Ser Gly Asn Gly Glu Ile Gln Asn Tyr Lys Leu Tyr Tyr Met
     610                 615                 620                
 Glu Lys Gly Thr Asp Lys Glu Gln Asp Val Asp Val Ser Ser His Ser
 625                 630                 635                 640
 Tyr Thr Ile Asn Gly Leu Lys Lys Tyr Thr Glu Tyr Ser Phe Arg Val
                 645                 650                 655    
 Val Ala Tyr Asn Lys His Gly Pro Gly Val Ser Thr Pro Asp Val Ala
             660                 665                 670        
 Val Arg Thr Leu Ser Asp Val Pro Ser Ala Ala Pro Gln Asn Leu Ser
         675                 680                 685            
 Leu Glu Val Arg Asn Ser Lys Ser Ile Met Ile His Trp Gln Pro Pro
     690                 695                 700                
 Ala Pro Ala Thr Gln Asn Gly Gln Ile Thr Gly Tyr Lys Ile Arg Tyr
 705                 710                 715                 720
 Arg Lys Ala Ser Arg Lys Ser Asp Val Thr Glu Thr Leu Val Ser Gly
                 725                 730                 735    
 Thr Gln Leu Ser Gln Leu Ile Glu Gly Leu Asp Arg Gly Thr Glu Tyr
             740                 745                 750        
 Asn Phe Arg Val Ala Ala Leu Thr Ile Asn Gly Thr Gly Pro Ala Thr
         755                 760                 765            
 Asp Trp Leu Ser Ala Glu Thr Phe Glu Ser Asp Leu Asp Glu Thr Arg
     770                 775                 780                
 Val Pro Glu Val Pro Ser Ser Leu His Val Arg Pro Leu Val Thr Ser
 785                 790                 795                 800
 Ile Val Val Ser Trp Thr Pro Pro Glu Asn Gln Asn Ile Val Val Arg
                 805                 810                 815    
 Gly Tyr Ala Ile Gly Tyr Gly Ile Gly Ser Pro His Ala Gln Thr Ile
             820                 825                 830        
 Lys Val Asp Tyr Lys Gln Arg Tyr Tyr Thr Ile Glu Asn Leu Asp Pro
         835                 840                 845            
 Ser Ser His Tyr Val Ile Thr Leu Lys Ala Phe Asn Asn Val Gly Glu
     850                 855                 860                
 Gly Ile Pro Leu Tyr Glu Ser Ala Val Thr Arg Pro His Thr Asp Thr
 865                 870                 875                 880
 Ser Glu Val Asp Leu Phe Val Ile Asn Ala Pro Tyr Thr Pro Val Pro
                 885                 890                 895    
 Asp Pro Thr Pro Met Met Pro Pro Val Gly Val Gln Ala Ser Ile Leu
             900                 905                 910        
 Ser His Asp Thr Ile Arg Ile Thr Trp Ala Asp Asn Ser Leu Pro Lys
         915                 920                 925            
 His Gln Lys Ile Thr Asp Ser Arg Tyr Tyr Thr Val Arg Trp Lys Thr
     930                 935                 940                
 Asn Ile Pro Ala Asn Thr Lys Tyr Lys Asn Ala Asn Ala Thr Thr Leu
 945                 950                 955                 960
 Ser Tyr Leu Val Thr Gly Leu Lys Pro Asn Thr Leu Tyr Glu Phe Ser
                 965                 970                 975    
 Val Met Val Thr Lys Gly Arg Arg Ser Ser Thr Trp Ser Met Thr Ala
             980                 985                 990        
 His Gly Thr Thr Phe Glu Leu Val Pro Thr Ser Pro Pro Lys Asp Val
         995                1000                1005            
 Thr Val Val Ser Lys Glu Gly Lys Pro Lys Thr Ile Ile Val Asn Trp
    1010                1015                1020                
 Gln Pro Pro Ser Glu Ala Asn Gly Lys Ile Thr Gly Tyr Ile Ile Tyr
1025                1030                1035                1040
 Tyr Ser Thr Asp Val Asn Ala Glu Ile His Asp Trp Val Ile Glu Pro
                1045                1050                1055    
 Val Val Gly Asn Arg Leu Thr His Gln Ile Gln Glu Leu Thr Leu Asp
            1060                1065                1070        
 Thr Pro Tyr Tyr Phe Lys Ile Gln Ala Arg Asn Ser Lys Gly Met Gly
        1075                1080                1085            
 Pro Met Ser Glu Ala Val Gln Phe Arg Thr Pro Lys Ala Asp Ser Ser
    1090                1095                1100                
 Asp Lys Met Pro Asn Asp Gln Ala Ser Gly Ser Gly Gly Lys Gly Ser
1105                1110                1115                1120
 Arg Leu Pro Asp Leu Gly Ser Asp Tyr Lys Pro Pro Met Ser Gly Ser
                1125                1130                1135    
 Asn Ser Pro His Gly Ser Pro Thr Ser Pro Leu Asp Ser Asn Met Leu
            1140                1145                1150        
 Leu Val Ile Ile Val Ser Val Gly Val Ile Thr Ile Val Val Val Val
        1155                1160                1165            
 Ile Ile Ala Val Phe Cys Thr Arg Arg Thr Thr Ser His Gln Lys Lys
    1170                1175                1180                
 Lys Arg Ala Ala Cys Lys Ser Val Asn Gly Ser His Lys Tyr Lys Gly
1185                1190                1195                1200
 Asn Ser Lys Asp Val Lys Pro Pro Asp Leu Trp Ile His His Glu Arg
                1205                1210                1215    
 Leu Glu Leu Lys Pro Ile Asp Lys Ser Pro Asp Pro Asn Pro Ile Met
            1220                1225                1230        
 Thr Asp Thr Pro Ile Pro Arg Asn Ser Gln Asp Ile Thr Pro Val Asp
        1235                1240                1245            
 Asn Ser Met Asp Ser Asn Ile His Gln Arg Arg Asn Ser Tyr Arg Gly
    1250                1255                1260                
 His Glu Ser Glu Asp Ser Met Ser Thr Leu Ala Gly Arg Arg Gly Met
1265                1270                1275                1280
 Arg Pro Lys Met Met Met Pro Phe Asp Ser Gln Pro Pro Gln Pro Val
                1285                1290                1295    
 Ile Ser Ala His Pro Ile His Ser Leu Asp Asn Pro His His His Phe
            1300                1305                1310        
 His Ser Ser Ser Leu Ala Ser Pro Ala Arg Ser His Leu Tyr His Pro
        1315                1320                1325            
 Gly Ser Pro Trp Pro Ile Gly Thr Ser Met Ser Leu Ser Asp Arg Ala
    1330                1335                1340                
 Asn Ser Thr Glu Ser Val Arg Asn Thr Pro Ser Thr Asp Thr Met Pro
1345                1350                1355                1360
 Ala Ser Ser Ser Gln Thr Cys Cys Thr Asp His Gln Asp Pro Glu Gly
                1365                1370                1375    
 Ala Thr Ser Ser Ser Tyr Leu Ala Ser Ser Gln Glu Glu Asp Ser Gly
            1380                1385                1390        
 Gln Ser Leu Pro Thr Ala His Val Arg Pro Ser His Pro Leu Lys Ser
        1395                1400                1405            
 Phe Ala Val Pro Ala Ile Pro Pro Pro Gly Pro Pro Thr Tyr Asp Pro
    1410                1415                1420                
 Ala Leu Pro Ser Thr Pro Leu Leu Ser Gln Gln Ala Leu Asn His His
1425                1430                1435                1440
 Ile His Ser Val Lys Thr Ala Ser Ile Gly Thr Leu Gly Arg Ser Arg
                1445                1450                1455    
 Pro Pro Met Pro Val Val Val Pro Ser Ala Pro Glu Val Gln Glu Thr
            1460                1465                1470        
 Thr Arg Met Leu Glu Asp Ser Glu Ser Ser Tyr Glu Pro Asp Glu Leu
        1475                1480                1485            
 Thr Lys Glu Met Ala His Leu Glu Gly Leu Met Lys Asp Leu Asn Ala
    1490                1495                1500                
 Ile Thr Thr Ala
1505            



      <210> 3081
      <211> 144
      <212> PRT
      <213> Homo sapiens

      <220>
      <221> misc_feature
      <222> (1)...(144)
      <223> Xaa = any amino acid or symbol as shown in the table 8 as set forth in Example 2


      <400> 3081
 Gly Ile Pro Arg Glu Ala Tyr Leu Leu Glu His Ser His Asn Gly Gly
   1               5                  10                  15    
 Pro Val His Tyr Ala Glu Leu Arg Val Ala Trp Arg Arg Ala Pro Cys
              20                  25                  30        
 His Ala Gly Leu Ala Xaa Arg Thr Ala Ala Ala Pro Gly Arg Gln Gln
          35                  40                  45            
 Leu Leu Asp Gly Arg Ser Pro Pro Ala Gly Pro Arg Arg Ser Gly Trp
      50                  55                  60                
 Gln Arg Val His Leu Pro Gly His Ser Pro Ala Gln Asp Pro Xaa Pro
  65                  70                  75                  80
 Pro Leu Pro Pro Pro Ala Gly Gly Pro Pro Leu Gln Arg Leu Pro Ser
                  85                  90                  95    
 Gly Val Gly Cys Ser Arg His Gly Asn Gly Gly Ser Asn Gly Gly Leu
             100                 105                 110        
 Ser Thr Gly Val Pro Val Cys Cys Pro Ala Pro Arg Asp Phe Pro Pro
         115                 120                 125            
 Pro Trp Ser Ile Ala Cys Ser His Gly Ala Lys Ala Pro Thr Glu Gly
     130                 135                 140                





      <210> 3082
      <211> 112
      <212> PRT
      <213> Homo sapiens


      <400> 3082
 Met Thr Val Ser Gly Thr Val Val Leu Val Ala Gly Thr Leu Cys Phe
   1               5                  10                  15    
 Ala Trp Trp Ser Glu Gly Asp Ala Thr Ala Gln Pro Gly Gln Leu Ala
              20                  25                  30        
 Pro Pro Thr Glu Tyr Pro Val Pro Glu Gly Pro Ser Pro Leu Leu Arg
          35                  40                  45            
 Ser Val Ser Phe Val Cys Cys Gly Ala Gly Gly Leu Leu Leu Leu Ile
      50                  55                  60                
 Gly Leu Leu Trp Ser Val Lys Ala Ser Ile Pro Gly Pro Pro Arg Trp
  65                  70                  75                  80
 Asp Pro Tyr His Leu Ser Arg Asp Leu Tyr Tyr Leu Thr Val Glu Ser
                  85                  90                  95    
 Ser Glu Lys Glu Ser Cys Arg Thr Pro Lys Val Val Asp Ile Pro Asp
             100                 105                 110        





      <210> 3083
      <211> 406
      <212> PRT
      <213> Homo sapiens


      <400> 3083
 Ser Phe Leu Ser Ala Pro Leu Ile Gly Ala Leu Ser Asp Val Trp Gly
   1               5                  10                  15    
 Arg Lys Ser Phe Leu Leu Leu Thr Val Phe Phe Thr Cys Ala Pro Ile
              20                  25                  30        
 Pro Leu Met Lys Ile Ser Pro Trp Trp Tyr Phe Ala Val Ile Ser Val
          35                  40                  45            
 Ser Gly Val Phe Ala Val Thr Phe Ser Val Val Phe Ala Tyr Val Ala
      50                  55                  60                
 Asp Ile Thr Gln Glu His Glu Arg Ser Met Ala Tyr Gly Leu Val Ser
  65                  70                  75                  80
 Ala Thr Phe Ala Ala Ser Leu Val Thr Ser Pro Ala Ile Gly Ala Tyr
                  85                  90                  95    
 Leu Gly Arg Val Tyr Gly Asp Ser Leu Val Val Val Leu Ala Thr Ala
             100                 105                 110        
 Ile Ala Leu Leu Asp Ile Cys Phe Ile Leu Val Ala Val Pro Glu Ser
         115                 120                 125            
 Leu Pro Glu Lys Met Arg Pro Ala Ser Trp Gly Ala Pro Ile Ser Trp
     130                 135                 140                
 Glu Gln Ala Asp Pro Phe Ala Ser Leu Lys Lys Val Gly Gln Asp Ser
 145                 150                 155                 160
 Ile Val Leu Leu Ile Cys Ile Thr Val Phe Leu Ser Tyr Leu Pro Glu
                 165                 170                 175    
 Ala Gly Gln Tyr Ser Ser Phe Phe Leu Tyr Leu Arg Gln Ile Met Lys
             180                 185                 190        
 Phe Ser Pro Glu Ser Val Ala Ala Phe Ile Ala Val Leu Gly Ile Leu
         195                 200                 205            
 Ser Ile Ile Ala Gln Thr Ile Val Leu Ser Leu Leu Met Arg Ser Ile
     210                 215                 220                
 Gly Asn Lys Asn Thr Ile Leu Leu Gly Leu Gly Phe Gln Ile Leu Gln
 225                 230                 235                 240
 Leu Ala Trp Tyr Gly Phe Gly Ser Lys Pro Trp Met Met Trp Ala Ala
                 245                 250                 255    
 Gly Ala Val Ala Ala Met Ser Ser Ile Thr Phe Pro Ala Val Ser Ala
             260                 265                 270        
 Leu Val Ser Arg Thr Ala Asp Ala Asp Gln Gln Gly Val Val Gln Gly
         275                 280                 285            
 Met Ile Thr Gly Ile Arg Gly Leu Cys Asn Gly Leu Gly Pro Ala Leu
     290                 295                 300                
 Tyr Gly Phe Ile Phe Tyr Ile Phe His Val Glu Leu Lys Glu Leu Pro
 305                 310                 315                 320
 Ile Thr Gly Thr Asp Leu Gly Thr Asn Thr Ser Pro Gln His His Phe
                 325                 330                 335    
 Glu Gln Asn Ser Ile Ile Pro Gly Pro Pro Phe Leu Phe Gly Ala Cys
             340                 345                 350        
 Ser Val Leu Leu Ala Leu Leu Val Ala Leu Phe Ile Pro Glu His Thr
         355                 360                 365            
 Asn Leu Ser Leu Arg Ser Ser Ser Trp Arg Lys His Cys Gly Ser His
     370                 375                 380                
 Ser His Pro His Asn Thr Gln Ala Pro Gly Glu Ala Lys Glu Pro Leu
 385                 390                 395                 400
 Leu Gln Asp Thr Asn Val
                 405    



      <210> 3084
      <211> 194
      <212> PRT
      <213> Homo sapiens

      <220>
      <221> misc_feature
      <222> (1)...(194)
      <223> Xaa = any amino acid or symbol as shown in the table 8 as set forth in Example 2


      <400> 3084
 Arg Asp Thr Gly Ser Asp Pro Ser Ser Thr Arg Arg Leu Cys Ser Thr
   1               5                  10                  15    
 Cys Cys Thr Gly His Xaa Pro Ala Glu Pro Ile Ala Ser Pro His Pro
              20                  25                  30        
 Ser Arg Gly Thr Cys Pro Pro Ala Ser Ser Ala Ser Ser Arg Arg Thr
          35                  40                  45            
 Gly Cys Trp Thr Cys Pro Pro Glu Ser Gly His Ala Gln Ala Arg Arg
      50                  55                  60                
 Ser Arg Arg Ala Ser Ala Ser Arg Trp Gly Ala Arg Gly Ala Val Arg
  65                  70                  75                  80
 Ser Ala Val Ala Ala Arg Gly Cys Ser Ser Arg Ala Gly Arg Trp Leu
                  85                  90                  95    
 Glu Thr Pro Gly Arg Arg Arg Gly Pro Pro Ala Cys Ala Ala Ala Ala
             100                 105                 110        
 Gly Arg Leu Arg Gly Pro Ala Pro Xaa Ala Ala Pro Pro Thr Ala Ser
         115                 120                 125            
 Val Pro Ala Arg Cys Arg Cys Pro Ala Ala Arg Thr Gly Ala Pro Ala
     130                 135                 140                
 Ala Ala Thr Trp Leu Arg Arg Arg Leu Ser Gly Leu Arg Ala Pro Ala
 145                 150                 155                 160
 Leu Gly Arg Arg Arg Ser Pro Gly Pro Ser Pro Lys Ser Ala Ala Pro
                 165                 170                 175    
 Pro Leu Leu Thr Pro Leu Gly Ala Gly Arg Ala Gly Gly Ser Arg Ala
             180                 185                 190        
 Asn Ser
        



      <210> 3085
      <211> 262
      <212> PRT
      <213> Homo sapiens


      <400> 3085
 Glu Pro Leu Pro Gly His Val Leu Gly Lys Gly Lys Asp Leu Pro Ser
   1               5                  10                  15    
 Leu Cys Leu Cys Pro His Met Ala His Cys Ala Ala Ala Asp Val Thr
              20                  25                  30        
 Thr Arg Phe Asp Glu Val Phe Trp Phe Gly Asp Phe Asn Phe Arg Leu
          35                  40                  45            
 Ser Gly Gly Arg Thr Val Val Asp Ala Leu Leu Cys Gln Gly Leu Val
      50                  55                  60                
 Val Asp Val Pro Ala Leu Leu Gln His Asp Gln Leu Ile Arg Glu Met
  65                  70                  75                  80
 Arg Lys Gly Ser Ile Phe Lys Gly Phe Gln Glu Pro Asp Ile His Phe
                  85                  90                  95    
 Leu Pro Ser Tyr Lys Phe Asp Ile Gly Lys Asp Thr Tyr Asp Ser Thr
             100                 105                 110        
 Ser Lys Gln Arg Thr Pro Ser Tyr Thr Asp Arg Val Leu Tyr Arg Ser
         115                 120                 125            
 Arg His Lys Gly Asp Ile Cys Pro Val Ser Tyr Ser Ser Cys Pro Gly
     130                 135                 140                
 Ile Lys Thr Ser Asp His Arg Pro Val Tyr Gly Leu Phe Arg Val Lys
 145                 150                 155                 160
 Val Arg Pro Gly Arg Asp Asn Ile Pro Leu Ala Ala Gly Lys Phe Asp
                 165                 170                 175    
 Arg Glu Leu Tyr Leu Leu Gly Ile Lys Arg Arg Ile Ser Lys Glu Ile
             180                 185                 190        
 Gln Arg Gln Gln Ala Leu Gln Ser Gln Asn Ser Ser Thr Ile Cys Ser
         195                 200                 205            
 Val Phe Leu Lys Phe Ala Glu Arg Gly Leu Thr Ala Ala Thr Trp Gly
     210                 215                 220                
 Asp Cys Ile Asp Gln Asn Pro Leu Gly Arg Thr Lys Ser Leu Pro Pro
 225                 230                 235                 240
 Phe Gly Asp Pro Arg Asp Cys Gly Asp Arg Ala Ser Val Pro Ala Ser
                 245                 250                 255    
 Gln Glu Gly Ser Gln Pro
             260        



      <210> 3086
      <211> 130
      <212> PRT
      <213> Homo sapiens


      <400> 3086
 Leu Arg Gly Pro Met Asp Ser Asp Asp Ser His Gly Ser Val Leu Arg
   1               5                  10                  15    
 Leu Ser Gln Ala Leu Gly Asn Val Thr Val Val Gln Lys Gly Glu Arg
              20                  25                  30        
 Asp Ile Leu Ser Asn Gly Gln Gln Val Leu Val Cys Ser Gln Glu Gly
          35                  40                  45            
 Ser Ser Arg Arg Cys Gly Gly Gln Gly Asp Leu Leu Ser Gly Ser Leu
      50                  55                  60                
 Gly Val Leu Val His Trp Ala Leu Leu Ala Gly Pro Gln Lys Thr Asn
  65                  70                  75                  80
 Gly Ser Ser Pro Leu Leu Val Ala Ala Phe Gly Ala Cys Ser Leu Thr
                  85                  90                  95    
 Arg Gln Cys Asn His Gln Ala Phe Gln Lys His Gly Arg Ser Thr Thr
             100                 105                 110        
 Thr Ser Asp Met Ile Ala Glu Val Gly Ala Ala Phe Ser Lys Leu Phe
         115                 120                 125            
 Glu Thr
     130



      <210> 3087
      <211> 395
      <212> PRT
      <213> Homo sapiens


      <400> 3087
 Met Leu Pro Ala Pro Ser Leu Val Val Gly Val Glu Gly Val Thr Ala
   1               5                  10                  15    
 Gln Leu Leu Gln Arg Gln Arg Leu Pro Pro Pro Cys Ser Arg Pro Ala
              20                  25                  30        
 Gly Ser Glu His Leu Pro His Ala Asp Arg Ala Pro Ala Pro Met Phe
          35                  40                  45            
 Thr Met Leu Arg Lys Thr Cys Gly Gly Gln Gln Glu Asp Ser Arg Gly
      50                  55                  60                
 Met Gly Pro His Leu Pro Arg Arg Leu Ala Ala Gly Trp Phe Leu Phe
  65                  70                  75                  80
 Gln Lys Ser Val Gln Ile Leu Ser Ser Gly Phe Ala Leu Pro Lys Thr
                  85                  90                  95    
 Gln Ser Ala Pro Arg Leu Ser Pro Trp Thr Ser Gly Glu Arg Gly Leu
             100                 105                 110        
 Ser Leu Cys Ala Leu Gln Val Gln Cys Val Gly Ala Ser Pro Gly Pro
         115                 120                 125            
 Cys Thr Gly Ser Val Ala Pro Ala Ala Cys Gly Lys Arg Gln Ser Ser
     130                 135                 140                
 Cys Met Pro Asp Leu Ala Pro His Gly Ser Leu Gly Ser Ser Ala Leu
 145                 150                 155                 160
 Ala Val Gly Thr Gly Arg Leu Ile Arg Val His Ala Ala Pro Pro Pro
                 165                 170                 175    
 Ser Pro Leu Ser Gly Ser Val Val Ser Asn Asn Leu Ala Ala Thr Thr
             180                 185                 190        
 Gln Val Ala Lys Val Lys Leu Lys Phe Gln Ala Ala Phe Pro Asn Pro
         195                 200                 205            
 Glu Ile Glu Asn Lys Leu Ala Lys Cys Glu Pro Ser Arg Ala Arg Ser
     210                 215                 220                
 Thr Ala Leu Thr Gln Met Thr Asp Asp Pro Thr Ser Ser Ser Pro Ala
 225                 230                 235                 240
 Ser Gly Pro Thr Thr Arg Pro Tyr Tyr Cys Phe Thr Ala Pro Ser Pro
                 245                 250                 255    
 Pro Val Glu Leu Asn Ile Glu Phe Ile Leu Asn Gly Val Thr Trp Ile
             260                 265                 270        
 Ser Ala Trp Ala Phe Ile Gly Val Leu Ser Ala Met Gly Phe Gly His
         275                 280                 285            
 Val Asn Val Asn Lys Met Ser Ile Arg Val Glu Trp Ile Thr Ala Phe
     290                 295                 300                
 Thr Ile Ala Ala Gly Arg Ala Ala Thr Gly Tyr Leu Ala Tyr Lys Arg
 305                 310                 315                 320
 Phe Tyr Asp Lys Asp His Gln Asn Lys Ala Met Met Asn Leu His Ile
                 325                 330                 335    
 Gln Lys Asp Asn Pro Lys Ile Val His Ala Phe Asp Met Glu Asp Leu
             340                 345                 350        
 Glu Asp Lys Ala Val Tyr Cys His Cys Trp Arg Tyr Lys Lys Phe Pro
         355                 360                 365            
 Phe Cys Asp Gly Ser His Thr Lys His Asn Glu Gln Thr Gly Asp Asn
     370                 375                 380                
 Val Gly Pro Leu Ile Ile Glu Lys Lys Glu Thr
 385                 390                 395



      <210> 3088
      <211> 718
      <212> PRT
      <213> Homo sapiens


      <400> 3088
 Met Arg Ala Val Leu Asp Thr Ala Asp Ile Ala Ile Val Ala Leu Tyr
   1               5                  10                  15    
 Phe Ile Leu Val Met Cys Ile Gly Phe Phe Ala Met Trp Lys Ser Asn
              20                  25                  30        
 Arg Ser Thr Val Ser Gly Tyr Phe Leu Ala Gly Arg Ser Met Thr Trp
          35                  40                  45            
 Val Thr Ile Gly Ala Ser Leu Phe Val Ser Asn Ile Gly Ser Glu His
      50                  55                  60                
 Phe Ile Gly Leu Ala Gly Ser Gly Ala Ala Ser Gly Phe Ala Val Gly
  65                  70                  75                  80
 Ala Trp Glu Phe Asn Ala Leu Leu Leu Leu Gln Leu Leu Gly Trp Val
                  85                  90                  95    
 Phe Ile Pro Ile Tyr Ile Arg Ser Gly Val Tyr Thr Met Pro Glu Tyr
             100                 105                 110        
 Leu Ser Lys Arg Phe Gly Gly His Arg Ile Gln Val Tyr Phe Ala Ala
         115                 120                 125            
 Leu Ser Leu Ile Leu Tyr Ile Phe Thr Lys Leu Ser Val Asp Leu Tyr
     130                 135                 140                
 Ser Gly Ala Leu Phe Ile Gln Glu Ser Leu Gly Trp Asn Leu Tyr Val
 145                 150                 155                 160
 Ser Val Ile Leu Leu Ile Gly Met Thr Ala Leu Leu Thr Val Thr Gly
                 165                 170                 175    
 Gly Leu Val Ala Val Ile Tyr Thr Asp Thr Leu Gln Ala Leu Leu Met
             180                 185                 190        
 Ile Ile Gly Ala Leu Thr Leu Met Ile Ile Ser Ile Met Glu Ile Gly
         195                 200                 205            
 Gly Phe Glu Glu Val Lys Arg Arg Tyr Met Leu Ala Ser Pro Asp Val
     210                 215                 220                
 Thr Ser Ile Leu Leu Thr Tyr Asn Leu Ser Asn Thr Asn Ser Cys Asn
 225                 230                 235                 240
 Val Ser Pro Lys Lys Glu Ala Leu Lys Met Leu Arg Asn Pro Thr Asp
                 245                 250                 255    
 Glu Asp Val Pro Trp Pro Gly Phe Ile Leu Gly Gln Thr Pro Ala Ser
             260                 265                 270        
 Val Trp Tyr Trp Cys Ala Asp Gln Val Ile Val Gln Arg Val Leu Ala
         275                 280                 285            
 Ala Lys Asn Ile Ala His Ala Lys Gly Ser Thr Leu Met Ala Gly Phe
     290                 295                 300                
 Leu Lys Leu Leu Pro Met Phe Ile Ile Val Val Pro Gly Met Ile Ser
 305                 310                 315                 320
 Arg Ile Leu Phe Thr Asp Asp Ile Ala Cys Ile Asn Pro Glu His Cys
                 325                 330                 335    
 Met Leu Val Cys Gly Ser Arg Ala Gly Cys Ser Asn Ile Ala Tyr Pro
             340                 345                 350        
 Arg Leu Val Met Lys Leu Val Pro Val Gly Leu Arg Gly Leu Met Met
         355                 360                 365            
 Ala Val Met Ile Ala Ala Leu Met Ser Asp Leu Asp Ser Ile Phe Asn
     370                 375                 380                
 Ser Ala Ser Thr Ile Phe Thr Leu Asp Val Tyr Lys Leu Ile Arg Lys
 385                 390                 395                 400
 Ser Ala Ser Ser Arg Glu Leu Met Ile Val Gly Arg Ile Phe Val Ala
                 405                 410                 415    
 Phe Met Val Val Ile Ser Ile Ala Trp Val Pro Ile Ile Val Glu Met
             420                 425                 430        
 Gln Gly Gly Gln Met Tyr Leu Tyr Ile Gln Glu Val Ala Asp Tyr Leu
         435                 440                 445            
 Thr Pro Pro Val Ala Ala Leu Phe Leu Leu Ala Ile Phe Trp Lys Arg
     450                 455                 460                
 Cys Asn Glu Gln Gly Ala Phe Tyr Gly Gly Met Ala Gly Phe Val Leu
 465                 470                 475                 480
 Gly Ala Val Arg Leu Ile Leu Ala Phe Ala Tyr Arg Ala Pro Glu Cys
                 485                 490                 495    
 Asp Gln Pro Asp Asn Arg Pro Gly Phe Ile Lys Asp Ile His Tyr Met
             500                 505                 510        
 Tyr Val Ala Thr Gly Leu Phe Trp Val Thr Gly Leu Ile Thr Val Ile
         515                 520                 525            
 Val Ser Leu Leu Thr Pro Pro Pro Thr Lys Glu Gln Ile Arg Thr Thr
     530                 535                 540                
 Thr Phe Trp Ser Lys Lys Asn Leu Val Val Lys Glu Asn Cys Ser Pro
 545                 550                 555                 560
 Lys Glu Glu Pro Tyr Gln Met Gln Glu Lys Ser Ile Leu Arg Cys Ser
                 565                 570                 575    
 Glu Asn Asn Glu Thr Ile Asn His Ile Ile Pro Asn Gly Lys Ser Glu
             580                 585                 590        
 Asp Ser Ile Lys Gly Leu Gln Pro Glu Asp Val Asn Leu Leu Val Thr
         595                 600                 605            
 Cys Arg Glu Glu Gly Asn Pro Val Ala Ser Leu Gly His Ser Glu Ala
     610                 615                 620                
 Glu Thr Pro Val Asp Ala Tyr Ser Asn Gly Gln Ala Ala Leu Met Gly
 625                 630                 635                 640
 Glu Lys Glu Arg Lys Lys Glu Thr Asp Asp Gly Gly Arg Tyr Trp Lys
                 645                 650                 655    
 Phe Ile Asp Trp Phe Cys Gly Phe Lys Ser Lys Ser Leu Ser Lys Arg
             660                 665                 670        
 Ser Leu Arg Asp Leu Met Glu Glu Glu Ala Val Cys Leu Gln Met Leu
         675                 680                 685            
 Glu Glu Thr Arg Gln Val Lys Val Ile Leu Asn Ile Gly Leu Phe Ala
     690                 695                 700                
 Val Cys Ser Leu Gly Ile Phe Met Phe Val Tyr Phe Ser Leu
 705                 710                 715            



      <210> 3089
      <211> 139
      <212> PRT
      <213> Homo sapiens

      <220>
      <221> misc_feature
      <222> (1)...(139)
      <223> Xaa = any amino acid or symbol as shown in the table 8 as set forth in Example 2


      <400> 3089
 Val Ala Phe Ala Phe His Leu Leu Asp Val Ala Asp Asn Ala Leu Gln
   1               5                  10                  15    
 Thr Leu Glu Glu Thr Ala Phe Pro Ser Pro Asp Lys Leu Val Thr Leu
              20                  25                  30        
 Arg Leu Ser Gly Tyr Pro Leu Thr Cys Asp Cys Arg Leu Leu Trp Leu
          35                  40                  45            
 Leu Arg Leu Arg Arg His Leu Asp Phe Gly Met Ser Pro Pro Ala Cys
      50                  55                  60                
 Ala Gly Pro His His Val Gln Gly Lys Ser Leu Lys Glu Phe Ser Asp
  65                  70                  75                  80
 Ile Leu Pro Pro Gly His Phe Thr Cys Lys Pro Ala Leu Ile Arg Lys
                  85                  90                  95    
 Ser Gly Pro Asp Gly Ser Leu Gln Arg Arg Ala Gly Met Arg Phe Ser
             100                 105                 110        
 Pro Ala Leu Glu Met Glu Thr Gln Pro Pro Leu Ser Pro Gly Xaa Gly
         115                 120                 125            
 Leu Met Gly Leu Ala Gly Gln Gly Trp Thr Lys
     130                 135                



      <210> 3090
      <211> 84
      <212> PRT
      <213> Homo sapiens


      <400> 3090
 Trp Met Met Leu Glu Thr Ile Ile Leu Ser Lys Leu Ser Gln Gly Gln
   1               5                  10                  15    
 Lys Thr Lys His Cys Met Phe Ser Leu Lys Gly Leu Ser Met Val Ala
              20                  25                  30        
 Tyr Ser Val Gln Val Leu Ala Val Phe Ile Ser Cys Ala Ile Leu Thr
          35                  40                  45            
 Leu Ala Met Lys Ile Ala Trp Ile Phe Gly Leu Asn Ser Val Gln Asn
      50                  55                  60                
 Ile Thr Ala Asn Leu Ser Val Asp Gly Ser Thr Ser Gly Asn Pro Ile
  65                  70                  75                  80
 Gln Lys Trp Lys
                



      <210> 3091
      <211> 417
      <212> PRT
      <213> Homo sapiens


      <400> 3091
 Met Gly Leu Leu Leu Met Ile Leu Ala Ser Ala Val Leu Gly Ser Phe
   1               5                  10                  15    
 Leu Thr Leu Leu Ala Gln Phe Phe Leu Leu Tyr Arg Arg Gln Pro Glu
              20                  25                  30        
 Pro Pro Ala Asp Glu Ala Ala Arg Ala Gly Glu Gly Phe Arg Tyr Ile
          35                  40                  45            
 Lys Pro Val Pro Gly Leu Leu Leu Arg Glu Tyr Leu Tyr Gly Gly Gly
      50                  55                  60                
 Arg Asp Glu Glu Pro Ser Gly Ala Ala Pro Glu Gly Gly Ala Thr Pro
  65                  70                  75                  80
 Thr Ala Ala Pro Glu Thr Pro Ala Pro Pro Thr Arg Glu Thr Cys Tyr
                  85                  90                  95    
 Phe Leu Asn Ala Thr Ile Leu Phe Leu Phe Arg Glu Leu Arg Asp Thr
             100                 105                 110        
 Ala Leu Thr Arg Arg Trp Val Thr Lys Lys Ile Lys Val Glu Phe Glu
         115                 120                 125            
 Glu Leu Leu Gln Thr Lys Thr Ala Gly Arg Leu Leu Glu Gly Leu Ser
     130                 135                 140                
 Leu Arg Asp Val Phe Leu Gly Glu Thr Val Pro Phe Ile Lys Thr Ile
 145                 150                 155                 160
 Arg Leu Val Arg Pro Val Val Pro Ser Ala Thr Gly Glu Pro Asp Gly
                 165                 170                 175    
 Pro Glu Gly Glu Ala Leu Pro Ala Ala Cys Pro Glu Glu Leu Ala Phe
             180                 185                 190        
 Glu Ala Glu Val Glu Tyr Asn Gly Gly Phe His Leu Ala Ile Asp Val
         195                 200                 205            
 Asp Leu Val Phe Gly Lys Ser Ala Tyr Leu Phe Val Lys Leu Ser Arg
     210                 215                 220                
 Val Val Gly Arg Leu Arg Leu Val Phe Thr Arg Val Pro Phe Thr His
 225                 230                 235                 240
 Trp Phe Phe Ser Phe Val Glu Asp Pro Leu Ile Asp Phe Glu Val Arg
                 245                 250                 255    
 Ser Gln Phe Glu Gly Arg Pro Met Pro Gln Leu Thr Ser Ile Ile Val
             260                 265                 270        
 Asn Gln Leu Lys Lys Ile Ile Lys Arg Lys His Thr Leu Pro Asn Tyr
         275                 280                 285            
 Lys Ile Arg Phe Lys Pro Phe Phe Pro Tyr Gln Thr Leu Gln Gly Phe
     290                 295                 300                
 Glu Glu Asp Glu Glu His Ile His Ile Gln Gln Trp Ala Leu Thr Glu
 305                 310                 315                 320
 Gly Arg Leu Lys Val Thr Leu Leu Glu Cys Ser Arg Leu Leu Ile Phe
                 325                 330                 335    
 Gly Ser Tyr Asp Arg Glu Ala Asn Val His Cys Thr Leu Glu Leu Ser
             340                 345                 350        
 Ser Ser Val Trp Glu Glu Lys Gln Arg Ser Ser Ile Lys Thr Gly Thr
         355                 360                 365            
 Ile Ser Leu Thr Ala Val Phe Met Gly Trp His Arg Val Ser Glu Ala
     370                 375                 380                
 Phe Pro Gly Leu Trp Tyr Lys Leu Leu Val Asp Leu Pro Phe Trp Gly
 385                 390                 395                 400
 Leu Glu Asp Gly Gly Pro Leu Leu Thr Val Pro Leu Arg Gln Cys Pro
                 405                 410                 415    
 Gly
    



      <210> 3092
      <211> 165
      <212> PRT
      <213> Homo sapiens


      <400> 3092
 Glu Arg Pro Arg Ile Met Asp Leu Ala Gly Leu Leu Lys Ser Gln Phe
   1               5                  10                  15    
 Leu Cys His Leu Val Phe Cys Tyr Val Phe Ile Ala Ser Gly Leu Ile
              20                  25                  30        
 Ile Asn Thr Ile Gln Leu Phe Thr Leu Leu Leu Trp Pro Ile Asn Lys
          35                  40                  45            
 Gln Leu Phe Arg Lys Ile Asn Cys Arg Leu Ser Tyr Cys Ile Ser Ser
      50                  55                  60                
 Gln Leu Val Met Leu Leu Glu Trp Trp Ser Gly Thr Glu Cys Thr Ile
  65                  70                  75                  80
 Phe Thr Asp Pro Arg Ala Tyr Leu Lys Tyr Gly Lys Glu Asn Ala Ile
                  85                  90                  95    
 Val Val Leu Asn His Lys Phe Gly Asn Ile Asp Phe Leu Cys Gly Trp
             100                 105                 110        
 Ser Leu Ser Glu Arg Phe Gly Leu Leu Gly Val Ser Gln Lys Cys Ile
         115                 120                 125            
 Pro Pro Cys Leu Thr His Phe Phe Gly Ser Ala Pro Pro Leu Val Phe
     130                 135                 140                
 Leu Leu Leu Val Ile Gln Asn Leu Gln Lys Asn Gln Gln Ser Phe Tyr
 145                 150                 155                 160
 Leu Met Lys Trp Ser
                 165



      <210> 3093
      <211> 128
      <212> PRT
      <213> Homo sapiens


      <400> 3093
 Val Ala Gln Arg Met Thr Val Val Val Leu Lys Ala Arg His Leu Pro
   1               5                  10                  15    
 Lys Met Asp Ile Thr Gly Leu Ser Gly Asn Pro Tyr Val Lys Val Asn
              20                  25                  30        
 Val Tyr Tyr Gly Arg Lys Arg Ile Ala Lys Lys Lys Thr His Val Lys
          35                  40                  45            
 Lys Cys Thr Leu Asn Pro Ile Phe Asn Glu Ser Phe Ile Tyr Asp Ile
      50                  55                  60                
 Pro Thr Asp Leu Leu Pro Asp Ile Ser Ile Glu Phe Leu Val Ile Asp
  65                  70                  75                  80
 Phe Asp Arg Thr Thr Lys Asn Glu Val Val Gly Arg Leu Ile Leu Gly
                  85                  90                  95    
 Ala His Ser Val Thr Ala Ser Gly Ala Glu His Trp Arg Glu Val Cys
             100                 105                 110        
 Glu Ser Pro Arg Lys Pro Val Ala Lys Trp His Ser Leu Ser Glu Tyr
         115                 120                 125            





      <210> 3094
      <211> 264
      <212> PRT
      <213> Homo sapiens

      <220>
      <221> misc_feature
      <222> (1)...(264)
      <223> Xaa = any amino acid or symbol as shown in the table 8 as set forth in Example 2


      <400> 3094
 Thr Leu Gly Ser Ala Val Glu Phe Pro Gln Asp Val Asp Lys Glu Ala
   1               5                  10                  15    
 Met Met Glu Ala Gly Trp Asp Pro Cys Leu Gln Ala Pro Phe His Leu
              20                  25                  30        
 Thr Pro Thr Leu Tyr Arg Thr Leu Arg Asn Gln Gly Asn Gln Gly Ala
          35                  40                  45            
 Pro Ala Glu Ser Arg Glu Val Leu Gln Asp Thr Val Asn Leu Leu Phe
      50                  55                  60                
 Asn His Pro Arg Gln Arg Asn Ala Ser Arg Glu Asn Leu Asn Leu Pro
  65                  70                  75                  80
 Glu Pro Gln Pro Ala Thr Gly Gln Pro Arg Ser Arg Pro Leu Lys Val
                  85                  90                  95    
 Ala Gly Ser Pro Thr Gly Arg Leu Ala Gly Asp Gln Gly Ser Glu Glu
             100                 105                 110        
 Ala Pro Gln Arg Pro Pro Ala Ser Ser Ala Thr Leu Arg Arg Gln Arg
         115                 120                 125            
 His Leu Asn Gly Lys Val Ser Pro Glu Lys Glu Ser Gly Pro Arg Gln
     130                 135                 140                
 Ile Leu Arg Ser Leu Val Arg Leu Ser Val Ala Ala Phe Ala Glu Arg
 145                 150                 155                 160
 Asn Pro Val Glu Glu Leu Thr Val Asp Ser Pro Pro Val Gln Gln Ile
                 165                 170                 175    
 Ser Gln Leu Leu Ser Leu Leu His Gln Gly Gln Phe Gln Pro Lys Pro
             180                 185                 190        
 Asn His Arg Gly Asn Lys Tyr Leu Ala Lys Pro Gly Gly Ser Arg Ser
         195                 200                 205            
 Ala Ile Pro Asp Thr Asp Gly Pro Ser Ala Arg Ala Gly Gly Gln Thr
     210                 215                 220                
 Asp Pro Glu Gln Glu Glu Gly Pro Leu Asp Pro Glu Glu Asp Leu Ser
 225                 230                 235                 240
 Val Lys Gln Leu Leu Xaa Glu Glu Leu Ser Ser Leu Leu Asp Pro Ser
                 245                 250                 255    
 Thr Gly Leu Ala Leu Asp Arg Leu
             260                



      <210> 3095
      <211> 315
      <212> PRT
      <213> Homo sapiens


      <400> 3095
 Trp Lys Ala Met Glu Ser Ala Leu Pro Ala Ala Gly Phe Leu Tyr Trp
   1               5                  10                  15    
 Val Gly Ala Gly Thr Val Ala Tyr Leu Ala Leu Arg Ile Ser Tyr Ser
              20                  25                  30        
 Leu Phe Thr Ala Leu Arg Val Trp Gly Val Gly Asn Glu Ala Gly Val
          35                  40                  45            
 Gly Pro Gly Leu Gly Glu Trp Ala Val Val Thr Gly Ser Thr Asp Gly
      50                  55                  60                
 Ile Gly Lys Ser Tyr Ala Glu Glu Leu Ala Lys His Gly Met Lys Val
  65                  70                  75                  80
 Val Leu Ile Ser Arg Ser Lys Asp Lys Leu Asp Gln Val Ser Ser Glu
                  85                  90                  95    
 Ile Lys Glu Lys Phe Lys Val Glu Thr Arg Thr Ile Ala Val Asp Phe
             100                 105                 110        
 Ala Ser Glu Asp Ile Tyr Asp Lys Ile Lys Thr Gly Leu Ala Gly Leu
         115                 120                 125            
 Glu Ile Gly Ile Leu Val Asn Asn Val Gly Met Ser Tyr Glu Tyr Pro
     130                 135                 140                
 Glu Tyr Phe Leu Asp Val Pro Asp Leu Asp Asn Val Ile Lys Lys Met
 145                 150                 155                 160
 Ile Asn Ile Asn Ile Leu Ser Val Cys Lys Met Thr Gln Leu Val Leu
                 165                 170                 175    
 Pro Gly Met Val Glu Arg Ser Lys Gly Ala Ile Leu Asn Ile Ser Ser
             180                 185                 190        
 Gly Ser Gly Met Leu Pro Val Pro Leu Leu Thr Ile Tyr Ser Ala Thr
         195                 200                 205            
 Lys Thr Phe Val Asp Phe Phe Ser Gln Cys Leu His Glu Glu Tyr Arg
     210                 215                 220                
 Ser Lys Gly Val Phe Val Gln Ser Val Leu Pro Tyr Phe Val Ala Thr
 225                 230                 235                 240
 Lys Leu Ala Lys Ile Arg Lys Pro Thr Leu Asp Lys Pro Ser Pro Glu
                 245                 250                 255    
 Thr Phe Val Lys Ser Ala Ile Lys Thr Val Gly Leu Gln Ser Arg Thr
             260                 265                 270        
 Asn Gly Tyr Leu Ile His Ala Leu Met Gly Leu Ile Ile Ser Asn Leu
         275                 280                 285            
 Pro Ser Trp Ile Tyr Leu Lys Ile Val Met Asn Met Asn Lys Ser Thr
     290                 295                 300                
 Arg Ala His Tyr Leu Lys Lys Thr Lys Lys Asn
 305                 310                 315



      <210> 3096
      <211> 85
      <212> PRT
      <213> Homo sapiens


      <400> 3096
 Trp Phe Lys Cys Tyr Gly Cys Asn Ser Ser Arg Asp Trp Gln Arg Ser
   1               5                  10                  15    
 Thr Tyr Leu Leu Ser Trp Glu Val Arg Gly Arg Pro Val Pro Asp Ser
              20                  25                  30        
 Gly Cys Lys Ala Val Val Ala Leu Cys Ser Gln Pro Ala His Pro Ser
          35                  40                  45            
 Asn Ile Cys Lys Gly Val Gly Gly Cys Leu Thr Lys His Leu Leu Leu
      50                  55                  60                
 Met Gly Ala Met Gly Ile Arg Val Ala Cys Leu Glu Pro Arg Glu His
  65                  70                  75                  80
 Ile Glu Ala Ala Arg
                  85



      <210> 3097
      <211> 130
      <212> PRT
      <213> Homo sapiens


      <400> 3097
 Val Pro Lys Ile Ser Gly Pro Asp His Ile Asp Phe Ile Pro Trp Asp
   1               5                  10                  15    
 Gln Leu Phe Met Ala Ser Ser Ser Ser Val Thr Glu Phe Leu Val Leu
              20                  25                  30        
 Gly Phe Ser Ser Leu Gly Glu Leu Gln Leu Val Leu Phe Ala Val Phe
          35                  40                  45            
 Leu Cys Leu Tyr Leu Ile Ile Leu Ser Gly Asn Ile Ile Ile Ile Ser
      50                  55                  60                
 Val Ile His Leu Asp His Ser Leu His Thr Pro Met Tyr Phe Phe Leu
  65                  70                  75                  80
 Gly Ile Leu Ser Ile Ser Glu Ile Phe Tyr Thr Thr Val Ile Leu Pro
                  85                  90                  95    
 Lys Met Leu Ile Asn Leu Phe Ser Val Phe Arg Thr Leu Ser Phe Val
             100                 105                 110        
 Ser Cys Ala Thr Gln Met Phe Tyr Glu Ile Val Gly Pro Gly Thr Gln
         115                 120                 125            
 Glu Arg
     130



      <210> 3098
      <211> 127
      <212> PRT
      <213> Homo sapiens

      <220>
      <221> misc_feature
      <222> (1)...(127)
      <223> Xaa = any amino acid or symbol as shown in the table 8 as set forth in Example 2


      <400> 3098
 Gly Val Ser Val Pro Leu Leu Trp Gly Ala Ser Gln Leu Gly Tyr Leu
   1               5                  10                  15    
 Gly Val Met Asp Pro Leu Ala Glu Ala Val Cys Pro Phe Ser Asp Leu
              20                  25                  30        
 Gln Leu His Ser Gly Arg Thr Ser Thr Val Phe Lys Ala Ala Leu Gly
          35                  40                  45            
 Gln Ser Gly Ala His Cys Pro Glu Arg Cys Val Ser Ala Gln Ser Xaa
      50                  55                  60                
 Ala Asp Xaa Arg Ala Leu Arg Glu His Lys Gln Xaa Phe Gly Ser Thr
  65                  70                  75                  80
 Leu Cys Gly Pro Val Met Val Val Ala Met Glu Leu Gly Ser Ser Thr
                  85                  90                  95    
 Met Val Glu Leu Val Ser Ser Pro Ala Asn Ser Val Lys Val Phe Leu
             100                 105                 110        
 Phe Leu His Ile Phe Ser Ser Thr Cys Cys Phe Leu Thr Phe Ser
         115                 120                 125        



      <210> 3099
      <211> 101
      <212> PRT
      <213> Homo sapiens


      <400> 3099
 Asp Met Glu Glu Ala Ser Glu Gly Gly Gly Asn Asp Arg Val Arg Asn
   1               5                  10                  15    
 Leu Gln Ser Glu Val Glu Gly Val Lys Asn Ile Met Thr Gln Asn Val
              20                  25                  30        
 Glu Arg Ile Leu Ala Arg Gly Glu Asn Leu Glu His Leu Arg Asn Lys
          35                  40                  45            
 Thr Glu Asp Leu Glu Ala Thr Ser Glu His Phe Lys Thr Thr Ser Gln
      50                  55                  60                
 Lys Val Ala Arg Lys Phe Trp Trp Lys Asn Val Lys Met Ile Val Leu
  65                  70                  75                  80
 Ile Cys Val Ile Val Phe Ile Ile Ile Leu Phe Ile Val Leu Phe Ala
                  85                  90                  95    
 Thr Gly Ala Phe Ser
             100    



      <210> 3100
      <211> 153
      <212> PRT
      <213> Homo sapiens


      <400> 3100
 Met Gly Val Met Ala Pro Arg Thr Leu Leu Leu Leu Leu Leu Gly Ala
   1               5                  10                  15    
 Leu Ala Leu Thr Glu Thr Trp Ala Gly Glu Cys Gly Val Gly Arg Glu
              20                  25                  30        
 Arg Ala Ser Ala Gly Arg Ser Glu Trp Pro Ala Arg Pro Gly Glu Pro
          35                  40                  45            
 Arg Arg Glu Glu Gly Arg Ala Gly Leu Ser Leu Ser Ser Pro Pro Gly
      50                  55                  60                
 Ser His Ser Leu Arg Tyr Phe Ser Thr Ala Val Ser Gln Pro Gly Arg
  65                  70                  75                  80
 Gly Glu Pro Arg Phe Ile Ala Val Gly Tyr Val Asp Asp Thr Glu Phe
                  85                  90                  95    
 Val Arg Phe Asp Ser Asp Ser Val Ser Pro Arg Met Glu Arg Arg Ala
             100                 105                 110        
 Pro Trp Val Glu Gln Glu Gly Leu Glu Tyr Trp Asp Gln Glu Thr Arg
         115                 120                 125            
 Asn Ala Lys Gly His Ala Gln Ile Tyr Arg Val Asn Leu Arg Thr Leu
     130                 135                 140                
 Leu Arg Tyr Tyr Asn Gln Ser Glu Ala
 145                 150            



      <210> 3101
      <211> 187
      <212> PRT
      <213> Homo sapiens


      <400> 3101
 Cys Ser Glu Ile Phe Ala Ser Leu Arg Leu Pro Arg Ile Met Ala His
   1               5                  10                  15    
 Ser Lys Gln Pro Ser His Phe Gln Ser Leu Met Leu Leu Gln Trp Pro
              20                  25                  30        
 Leu Ser Tyr Leu Ala Ile Phe Trp Ile Leu Gln Pro Leu Phe Val Tyr
          35                  40                  45            
 Leu Leu Phe Thr Ser Leu Trp Pro Leu Pro Val Leu Tyr Phe Ala Trp
      50                  55                  60                
 Leu Phe Leu Asp Trp Lys Thr Pro Glu Arg Gly Gly Arg Arg Ser Ala
  65                  70                  75                  80
 Trp Val Arg Asn Trp Cys Val Trp Thr His Ile Arg Asp Tyr Phe Pro
                  85                  90                  95    
 Ile Thr Ile Leu Lys Thr Lys Asp Leu Ser Pro Glu His Asn Tyr Leu
             100                 105                 110        
 Met Gly Val His Pro His Gly Leu Leu Thr Phe Gly Ala Phe Cys Asn
         115                 120                 125            
 Phe Cys Thr Glu Ala Thr Gly Phe Ser Lys Thr Phe Pro Gly Ile Thr
     130                 135                 140                
 Pro His Leu Ala Thr Leu Ser Trp Phe Phe Lys Ile Pro Phe Val Arg
 145                 150                 155                 160
 Glu Tyr Leu Met Ala Lys Gly Ala Ser Asp His Thr Tyr Trp Ser Phe
                 165                 170                 175    
 Trp Ser Met Phe Leu Leu Gly Asn Ala Pro Phe
             180                 185        



      <210> 3102
      <211> 620
      <212> PRT
      <213> Homo sapiens


      <400> 3102
 Thr Arg Gly Ser Trp Ala Pro Glu Ser Leu Gly Ser Gln Val Met Ala
   1               5                  10                  15    
 Val Ala Gly Pro Ala Pro Gly Ala Gly Ala Arg Pro Arg Leu Asp Leu
              20                  25                  30        
 Gln Phe Leu Gln Arg Phe Leu Gln Ile Leu Lys Val Leu Phe Pro Ser
          35                  40                  45            
 Trp Ser Ser Gln Asn Ala Leu Met Phe Leu Thr Leu Leu Cys Leu Thr
      50                  55                  60                
 Leu Leu Glu Gln Phe Val Ile Tyr Gln Val Gly Leu Ile Pro Ser Gln
  65                  70                  75                  80
 Tyr Tyr Gly Val Leu Gly Asn Lys Asp Leu Glu Gly Phe Lys Thr Leu
                  85                  90                  95    
 Thr Phe Leu Ala Val Met Leu Ile Val Leu Asn Ser Thr Leu Lys Ser
             100                 105                 110        
 Phe Asp Gln Phe Thr Cys Asn Leu Leu Tyr Val Ser Trp Arg Lys Asp
         115                 120                 125            
 Leu Thr Glu His Leu His Arg Leu Tyr Phe Arg Gly Arg Ala Tyr Tyr
     130                 135                 140                
 Thr Leu Asn Val Leu Arg Asp Asp Ile Asp Asn Pro Asp Gln Arg Ile
 145                 150                 155                 160
 Ser Gln Asp Val Glu Arg Phe Cys Arg Gln Leu Ser Ser Met Ala Ser
                 165                 170                 175    
 Lys Leu Ile Ile Ser Pro Phe Thr Leu Val Tyr Tyr Thr Tyr Gln Cys
             180                 185                 190        
 Phe Gln Ser Thr Gly Trp Leu Gly Pro Val Ser Ile Phe Gly Tyr Phe
         195                 200                 205            
 Ile Leu Gly Thr Val Val Asn Lys Thr Leu Met Gly Pro Ile Val Met
     210                 215                 220                
 Lys Leu Val His Gln Glu Lys Leu Glu Gly Asp Phe Arg Phe Lys His
 225                 230                 235                 240
 Met Gln Ile Arg Val Asn Ala Glu Pro Ala Ala Phe Tyr Arg Ala Gly
                 245                 250                 255    
 His Val Glu His Met Arg Thr Asp Arg Arg Leu Gln Arg Leu Leu Gln
             260                 265                 270        
 Thr Gln Arg Glu Leu Met Ser Lys Glu Leu Trp Leu Tyr Ile Gly Ile
         275                 280                 285            
 Asn Thr Phe Asp Tyr Leu Gly Ser Ile Leu Ser Tyr Val Val Ile Ala
     290                 295                 300                
 Ile Pro Ile Phe Ser Gly Val Tyr Gly Asp Leu Ser Pro Ala Glu Leu
 305                 310                 315                 320
 Ser Thr Leu Val Ser Lys Asn Ala Phe Val Cys Ile Tyr Leu Ile Ser
                 325                 330                 335    
 Cys Phe Thr Gln Leu Ile Asp Leu Ser Thr Thr Leu Ser Asp Val Ala
             340                 345                 350        
 Gly Tyr Thr His Arg Ile Gly Gln Leu Arg Glu Thr Leu Leu Asp Met
         355                 360                 365            
 Ser Leu Lys Ser Gln Asp Cys Glu Ile Leu Gly Glu Ser Glu Trp Gly
     370                 375                 380                
 Leu Asp Thr Pro Pro Gly Trp Pro Ala Ala Glu Pro Ala Asp Thr Ala
 385                 390                 395                 400
 Phe Leu Leu Glu Arg Val Ser Ile Ser Ala Pro Ser Ser Asp Lys Pro
                 405                 410                 415    
 Leu Ile Lys Asp Leu Ser Leu Lys Ile Ser Glu Gly Gln Ser Leu Leu
             420                 425                 430        
 Ile Thr Gly Asn Thr Gly Thr Gly Lys Thr Ser Leu Leu Arg Val Leu
         435                 440                 445            
 Gly Gly Leu Trp Thr Ser Thr Arg Gly Ser Val Gln Met Leu Thr Asp
     450                 455                 460                
 Phe Gly Pro His Gly Val Leu Phe Leu Pro Gln Lys Pro Phe Phe Thr
 465                 470                 475                 480
 Asp Gly Thr Leu Arg Glu Gln Val Ile Tyr Pro Leu Lys Glu Val Tyr
                 485                 490                 495    
 Pro Asp Ser Gly Ser Ala Asp Asp Glu Arg Ile Leu Arg Phe Leu Glu
             500                 505                 510        
 Leu Ala Gly Leu Ser Asn Leu Val Ala Arg Thr Glu Gly Leu Asp Gln
         515                 520                 525            
 Gln Val Asp Trp Asn Trp Tyr Asp Val Leu Ser Pro Gly Glu Met Gln
     530                 535                 540                
 Arg Leu Ser Phe Ala Arg Leu Phe Tyr Leu Gln Pro Lys Tyr Ala Val
 545                 550                 555                 560
 Leu Asp Glu Ala Thr Ser Ala Leu Thr Glu Glu Val Glu Ser Glu Leu
                 565                 570                 575    
 Tyr Arg Ile Gly Gln Gln Leu Gly Met Thr Phe Ile Ser Val Gly His
             580                 585                 590        
 Arg Gln Ser Leu Glu Lys Phe His Ser Leu Val Leu Lys Leu Cys Gly
         595                 600                 605            
 Gly Gly Arg Trp Glu Leu Met Arg Ile Lys Val Glu
     610                 615                 620



      <210> 3103
      <211> 95
      <212> PRT
      <213> Homo sapiens


      <400> 3103
 Val Trp Ser Pro Ser Pro Glu Pro Gln Pro Thr Ala Ala Met Val Gly
   1               5                  10                  15    
 Lys Gly Ala Lys Gly Met Leu Asn Gly Ala Val Pro Ser Glu Ala Thr
              20                  25                  30        
 Lys Arg Asp Gln Asn Leu Lys Arg Gly Asn Trp Gly Asn Gln Ile Glu
          35                  40                  45            
 Phe Val Leu Thr Ser Val Gly Tyr Ala Val Gly Leu Gly Asn Val Arg
      50                  55                  60                
 Arg Phe Pro Tyr Leu Cys Tyr Arg Asn Gly Gly Gly Ala Phe Met Phe
  65                  70                  75                  80
 Pro Tyr Phe Ile Met Leu Ile Phe Cys Gly Ile Pro Leu Phe Phe
                  85                  90                  95



      <210> 3104
      <211> 1985
      <212> PRT
      <213> Homo sapiens


      <400> 3104
 Pro Gly Cys Ala Ala Arg Leu Ser Arg Ala Arg Ala Pro Gly Pro Gly
   1               5                  10                  15    
 Ala Ala Gly Ala Gly Arg Lys Arg Leu Ala Asp Pro Gly Pro Pro Pro
              20                  25                  30        
 Ala Ser Arg Arg Leu Arg Ala Pro Gly Ser Arg Pro Arg Leu Ala Pro
          35                  40                  45            
 Cys Thr Arg Arg Ala Ala Gln Pro Ala His Ala Arg Met Ala Pro Arg
      50                  55                  60                
 Ala Ala Gly Gly Ala Pro Leu Ser Ala Arg Ala Ala Ala Ala Ser Pro
  65                  70                  75                  80
 Pro Pro Phe Gln Thr Pro Pro Arg Cys Pro Val Pro Leu Leu Leu Leu
                  85                  90                  95    
 Leu Leu Leu Gly Ala Ala Arg Ala Gly Ala Leu Glu Ile Gln Arg Arg
             100                 105                 110        
 Phe Pro Ser Pro Thr Pro Thr Asn Asn Phe Ala Leu Asp Gly Ala Ala
         115                 120                 125            
 Gly Thr Val Tyr Leu Ala Ala Val Asn Arg Leu Tyr Gln Leu Ser Gly
     130                 135                 140                
 Ala Asn Leu Ser Leu Glu Ala Glu Ala Ala Val Gly Pro Val Pro Asp
 145                 150                 155                 160
 Ser Pro Leu Cys His Ala Pro Gln Leu Pro Gln Ala Ser Cys Glu His
                 165                 170                 175    
 Pro Arg Arg Leu Thr Asp Asn Tyr Asn Lys Ile Leu Gln Leu Asp Pro
             180                 185                 190        
 Gly Gln Gly Leu Val Val Val Cys Gly Ser Ile Tyr Gln Gly Phe Cys
         195                 200                 205            
 Gln Leu Arg Arg Arg Gly Asn Ile Ser Ala Val Ala Val Arg Phe Pro
     210                 215                 220                
 Pro Ala Ala Pro Pro Ala Glu Pro Val Thr Val Phe Pro Ser Met Leu
 225                 230                 235                 240
 Asn Val Ala Ala Asn His Pro Asn Ala Ser Thr Val Gly Leu Val Leu
                 245                 250                 255    
 Pro Pro Ala Ala Gly Ala Gly Gly Ser Arg Leu Leu Val Gly Ala Thr
             260                 265                 270        
 Tyr Thr Gly Tyr Gly Ser Ser Phe Phe Pro Arg Asn Arg Ser Leu Glu
         275                 280                 285            
 Asp His Arg Phe Glu Asn Thr Pro Glu Ile Ala Ile Arg Ser Leu Asp
     290                 295                 300                
 Thr Arg Gly Asp Leu Ala Lys Leu Phe Thr Phe Asp Leu Asn Pro Ser
 305                 310                 315                 320
 Asp Asp Asn Ile Leu Lys Ile Lys Gln Gly Ala Lys Glu Gln His Lys
                 325                 330                 335    
 Leu Gly Phe Val Ser Ala Phe Leu His Pro Ser Asp Pro Pro Pro Gly
             340                 345                 350        
 Ala Gln Ser Tyr Ala Tyr Leu Ala Leu Asn Ser Glu Ala Arg Ala Gly
         355                 360                 365            
 Asp Lys Glu Ser Gln Ala Arg Ser Leu Leu Ala Arg Ile Cys Leu Pro
     370                 375                 380                
 His Gly Ala Gly Gly Asp Ala Lys Lys Leu Thr Glu Ser Tyr Ile Gln
 385                 390                 395                 400
 Leu Gly Leu Gln Cys Ala Gly Gly Ala Gly Arg Gly Asp Leu Tyr Ser
                 405                 410                 415    
 Arg Leu Val Ser Val Phe Pro Ala Arg Glu Arg Leu Phe Ala Val Phe
             420                 425                 430        
 Glu Arg Pro Gln Gly Ser Pro Ala Ala Arg Ala Ala Pro Ala Ala Leu
         435                 440                 445            
 Cys Ala Phe Arg Phe Ala Asp Val Arg Ala Ala Ile Arg Ala Ala Arg
     450                 455                 460                
 Thr Ala Cys Phe Val Glu Pro Ala Pro Asp Val Val Ala Val Leu Asp
 465                 470                 475                 480
 Ser Val Val Gln Gly Thr Gly Pro Ala Cys Glu Arg Lys Leu Asn Ile
                 485                 490                 495    
 Gln Leu Gln Pro Glu Gln Leu Asp Cys Gly Ala Ala His Leu Gln His
             500                 505                 510        
 Pro Leu Ser Ile Leu Gln Pro Leu Lys Ala Thr Pro Val Phe Arg Ala
         515                 520                 525            
 Pro Gly Leu Thr Ser Val Ala Val Ala Ser Val Asn Asn Tyr Thr Ala
     530                 535                 540                
 Val Phe Leu Gly Thr Val Asn Gly Arg Leu Leu Lys Ile Asn Leu Asn
 545                 550                 555                 560
 Glu Ser Met Gln Val Val Ser Arg Arg Val Val Thr Val Ala Tyr Gly
                 565                 570                 575    
 Glu Pro Val His His Val Met Gln Phe Asp Pro Ala Asp Ser Val Tyr
             580                 585                 590        
 Leu Tyr Leu Met Thr Ser His Gln Met Ala Arg Val Lys Val Ala Ala
         595                 600                 605            
 Cys Asn Val His Ser Thr Cys Gly Asp Cys Val Gly Ala Ala Asp Ala
     610                 615                 620                
 Tyr Cys Gly Trp Cys Ala Leu Glu Thr Arg Cys Thr Leu Gln Gln Asp
 625                 630                 635                 640
 Cys Thr Asn Ser Ser Gln Gln His Phe Trp Thr Ser Ala Ser Glu Gly
                 645                 650                 655    
 Pro Ser Arg Cys Pro Ala Met Thr Val Leu Pro Ser Glu Ile Asp Val
             660                 665                 670        
 Arg Gln Glu Tyr Pro Gly Met Ile Leu Gln Ile Ser Gly Ser Leu Pro
         675                 680                 685            
 Ser Leu Ser Gly Met Glu Met Ala Cys Asp Tyr Gly Asn Asn Ile Arg
     690                 695                 700                
 Thr Val Ala Arg Val Pro Gly Pro Ala Phe Gly His Gln Ile Ala Tyr
 705                 710                 715                 720
 Cys Asn Leu Leu Pro Arg Asp Gln Phe Pro Pro Phe Pro Pro Asn Gln
                 725                 730                 735    
 Asp His Val Thr Val Glu Met Ser Val Arg Val Asn Gly Arg Asn Ile
             740                 745                 750        
 Val Lys Ala Asn Phe Thr Ile Tyr Asp Cys Ser Arg Thr Ala Gln Val
         755                 760                 765            
 Tyr Pro His Thr Ala Cys Thr Ser Cys Leu Ser Ala Gln Trp Pro Cys
     770                 775                 780                
 Phe Trp Cys Ser Gln Gln His Ser Cys Val Ser Asn Gln Ser Arg Cys
 785                 790                 795                 800
 Glu Ala Ser Pro Asn Pro Thr Ser Pro Gln Asp Cys Pro Arg Thr Leu
                 805                 810                 815    
 Leu Ser Pro Leu Ala Pro Val Pro Thr Gly Gly Ser Gln Asn Ile Leu
             820                 825                 830        
 Val Pro Leu Ala Asn Thr Ala Phe Phe Gln Gly Ala Ala Leu Glu Cys
         835                 840                 845            
 Ser Phe Gly Leu Glu Glu Ile Phe Glu Ala Val Trp Val Asn Glu Ser
     850                 855                 860                
 Val Val Arg Cys Asp Gln Val Val Leu His Thr Thr Arg Lys Ser Gln
 865                 870                 875                 880
 Val Phe Pro Leu Ser Leu Gln Leu Lys Gly Arg Pro Ala Arg Phe Leu
                 885                 890                 895    
 Asp Ser Pro Glu Pro Met Thr Val Met Val Tyr Asn Cys Ala Met Gly
             900                 905                 910        
 Ser Pro Asp Cys Ser Gln Cys Leu Gly Arg Glu Asp Leu Gly His Leu
         915                 920                 925            
 Cys Met Trp Ser Asp Gly Cys Arg Leu Arg Gly Pro Leu Gln Pro Met
     930                 935                 940                
 Ala Gly Thr Cys Pro Ala Pro Glu Ile Arg Ala Ile Glu Pro Leu Ser
 945                 950                 955                 960
 Gly Pro Leu Asp Gly Gly Thr Leu Leu Thr Ile Arg Gly Arg Asn Leu
                 965                 970                 975    
 Gly Arg Arg Leu Ser Asp Val Ala His Gly Val Trp Ile Gly Gly Val
             980                 985                 990        
 Ala Cys Glu Pro Leu Pro Asp Arg Tyr Thr Val Ser Glu Glu Ile Val
         995                1000                1005            
 Cys Val Thr Gly Pro Ala Pro Gly Pro Leu Ser Gly Val Val Thr Val
    1010                1015                1020                
 Asn Ala Ser Lys Glu Gly Lys Ser Arg Asp Arg Phe Ser Tyr Val Leu
1025                1030                1035                1040
 Pro Leu Val His Ser Leu Glu Pro Thr Met Gly Pro Lys Ala Gly Gly
                1045                1050                1055    
 Thr Arg Ile Thr Ile His Gly Asn Asp Leu His Val Gly Ser Glu Leu
            1060                1065                1070        
 Gln Val Leu Val Asn Asp Thr Asp Pro Cys Thr Glu Leu Met Arg Thr
        1075                1080                1085            
 Asp Thr Ser Ile Ala Cys Thr Met Pro Glu Gly Ala Leu Pro Ala Pro
    1090                1095                1100                
 Val Pro Val Cys Val Arg Phe Glu Arg Arg Gly Cys Val His Gly Asn
1105                1110                1115                1120
 Leu Thr Phe Trp Tyr Met Gln Asn Pro Val Ile Thr Ala Ile Ser Pro
                1125                1130                1135    
 Arg Arg Ser Pro Val Ser Gly Gly Arg Thr Ile Thr Val Ala Gly Glu
            1140                1145                1150        
 Arg Phe His Met Val Gln Asn Val Ser Met Ala Val His His Ile Gly
        1155                1160                1165            
 Arg Glu Pro Thr Leu Cys Lys Val Leu Asn Ser Thr Leu Ile Thr Cys
    1170                1175                1180                
 Pro Ser Pro Gly Ala Leu Ser Asn Ala Ser Ala Pro Val Asp Phe Phe
1185                1190                1195                1200
 Ile Asn Gly Arg Ala Tyr Ala Asp Glu Val Ala Val Ala Glu Glu Leu
                1205                1210                1215    
 Leu Asp Pro Glu Glu Ala Gln Arg Gly Ser Arg Phe Arg Leu Asp Tyr
            1220                1225                1230        
 Leu Pro Asn Pro Gln Phe Ser Thr Ala Lys Arg Glu Lys Trp Ile Lys
        1235                1240                1245            
 His His Pro Gly Glu Pro Leu Thr Leu Val Ile His Lys Glu Gln Asp
    1250                1255                1260                
 Ser Leu Gly Leu Gln Ser His Glu Tyr Arg Val Lys Ile Gly Gln Val
1265                1270                1275                1280
 Ser Cys Asp Ile Gln Ile Val Ser Asp Arg Ile Ile His Cys Ser Val
                1285                1290                1295    
 Asn Glu Ser Leu Gly Ala Ala Val Gly Gln Leu Pro Ile Thr Ile Gln
            1300                1305                1310        
 Val Gly Asn Phe Asn Gln Thr Ile Ala Thr Leu Gln Leu Gly Gly Ser
        1315                1320                1325            
 Glu Thr Ala Ile Ile Val Ser Ile Val Ile Cys Ser Val Leu Leu Leu
    1330                1335                1340                
 Leu Ser Val Val Ala Leu Phe Val Phe Cys Thr Lys Ser Arg Arg Ala
1345                1350                1355                1360
 Glu Arg Tyr Trp Gln Lys Thr Leu Leu Gln Met Glu Glu Met Glu Ser
                1365                1370                1375    
 Gln Ile Arg Glu Glu Ile Arg Lys Gly Phe Ala Glu Leu Gln Thr Asp
            1380                1385                1390        
 Met Thr Asp Leu Thr Lys Glu Leu Asn Arg Ser Gln Gly Ile Pro Phe
        1395                1400                1405            
 Leu Glu Tyr Lys His Phe Val Thr Arg Thr Phe Phe Pro Lys Cys Ser
    1410                1415                1420                
 Ser Leu Tyr Glu Glu Arg Tyr Val Leu Pro Ser Gln Thr Leu Asn Ser
1425                1430                1435                1440
 Gln Gly Ser Ser Gln Ala Gln Glu Thr His Pro Leu Leu Gly Glu Trp
                1445                1450                1455    
 Lys Ile Pro Glu Ser Cys Arg Pro Asn Met Glu Glu Gly Ile Ser Leu
            1460                1465                1470        
 Phe Ser Ser Leu Leu Asp Asn Lys His Phe Leu Ile Val Phe Val His
        1475                1480                1485            
 Ala Leu Glu Gln Gln Lys Asp Phe Ala Val Arg Asp Arg Cys Ser Leu
    1490                1495                1500                
 Ala Ser Leu Leu Thr Ile Ala Leu His Gly Lys Leu Glu Tyr Tyr Thr
1505                1510                1515                1520
 Ser Ile Met Lys Glu Leu Leu Val Asp Leu Ile Asp Ala Ser Ala Ala
                1525                1530                1535    
 Lys Asn Pro Lys Leu Met Leu Arg Arg Thr Glu Ser Val Val Glu Lys
            1540                1545                1550        
 Met Leu Thr Asn Trp Met Ser Ile Cys Met Tyr Ser Cys Leu Arg Glu
        1555                1560                1565            
 Thr Val Gly Glu Pro Phe Phe Leu Leu Leu Cys Ala Ile Lys Gln Gln
    1570                1575                1580                
 Ile Asn Lys Gly Ser Ile Asp Ala Ile Thr Gly Lys Ala Arg Tyr Thr
1585                1590                1595                1600
 Leu Asn Glu Glu Trp Leu Leu Arg Glu Asn Ile Glu Ala Lys Pro Arg
                1605                1610                1615    
 Asn Leu Asn Val Ser Phe Gln Gly Cys Gly Met Asp Ser Leu Ser Val
            1620                1625                1630        
 Arg Ala Met Asp Thr Asp Thr Leu Thr Gln Val Lys Glu Lys Ile Leu
        1635                1640                1645            
 Glu Ala Phe Cys Lys Asn Val Pro Tyr Ser Gln Trp Pro Arg Ala Glu
    1650                1655                1660                
 Asp Val Asp Leu Glu Trp Phe Ala Ser Ser Thr Gln Ser Tyr Ile Leu
1665                1670                1675                1680
 Arg Asp Leu Asp Asp Thr Ser Val Val Glu Asp Gly Arg Lys Lys Leu
                1685                1690                1695    
 Asn Thr Leu Ala His Tyr Lys Ile Pro Glu Gly Ala Ser Leu Ala Met
            1700                1705                1710        
 Ser Leu Ile Asp Lys Lys Asp Asn Thr Leu Gly Arg Val Lys Asp Leu
        1715                1720                1725            
 Asp Thr Glu Lys Tyr Phe His Leu Val Leu Pro Thr Asp Glu Leu Ala
    1730                1735                1740                
 Glu Pro Lys Lys Ser His Arg Gln Ser His Arg Lys Lys Val Leu Pro
1745                1750                1755                1760
 Glu Ile Tyr Leu Thr Arg Leu Leu Ser Thr Lys Gly Thr Leu Gln Lys
                1765                1770                1775    
 Phe Leu Asp Asp Leu Phe Lys Ala Ile Leu Ser Ile Arg Glu Asp Lys
            1780                1785                1790        
 Pro Pro Leu Ala Val Lys Tyr Phe Phe Asp Phe Leu Glu Glu Gln Ala
        1795                1800                1805            
 Glu Lys Arg Gly Ile Ser Asp Pro Asp Thr Leu His Ile Trp Lys Thr
    1810                1815                1820                
 Asn Ser Leu Pro Leu Arg Phe Trp Val Asn Ile Leu Lys Asn Pro Gln
1825                1830                1835                1840
 Phe Val Phe Asp Ile Asp Lys Thr Asp His Ile Asp Ala Cys Leu Ser
                1845                1850                1855    
 Val Ile Ala Gln Ala Phe Ile Asp Ala Cys Ser Ile Ser Asp Leu Gln
            1860                1865                1870        
 Leu Gly Lys Asp Ser Pro Thr Asn Lys Leu Leu Tyr Ala Lys Glu Ile
        1875                1880                1885            
 Pro Glu Tyr Arg Lys Ile Val Gln Arg Tyr Tyr Lys Gln Ile Gln Asp
    1890                1895                1900                
 Met Thr Pro Leu Ser Glu Gln Glu Met Asn Ala His Leu Ala Glu Glu
1905                1910                1915                1920
 Ser Arg Lys Tyr Gln Asn Glu Phe Asn Thr Asn Val Ala Met Ala Glu
                1925                1930                1935    
 Ile Tyr Lys Tyr Ala Lys Arg Tyr Arg Pro Gln Ile Met Ala Ala Leu
            1940                1945                1950        
 Glu Ala Asn Pro Thr Ala Arg Arg Thr Gln Leu Gln His Lys Phe Glu
        1955                1960                1965            
 Gln Val Val Ala Leu Met Glu Asp Asn Ile Tyr Glu Cys Tyr Ser Glu
    1970                1975                1980                
 Ala
1985



      <210> 3105
      <211> 484
      <212> PRT
      <213> Homo sapiens

      <220>
      <221> misc_feature
      <222> (1)...(484)
      <223> Xaa = any amino acid or symbol as shown in the table 8 as set forth in Example 2


      <400> 3105
 Arg Cys Phe Ser Pro Ser Leu Phe Pro Pro His Pro Val Phe Pro Ser
   1               5                  10                  15    
 Ser Arg Pro Pro Ser Pro Arg Met Tyr Ser Pro Tyr Cys Leu Thr Gln
              20                  25                  30        
 Asp Glu Phe His Pro Phe Ile Glu Ala Leu Leu Pro His Val Arg Ala
          35                  40                  45            
 Phe Ser Tyr Thr Trp Phe Asn Leu Gln Ala Arg Lys Arg Lys Tyr Phe
      50                  55                  60                
 Lys Lys His Glu Lys Arg Met Ser Lys Asp Glu Glu Arg Ala Val Lys
  65                  70                  75                  80
 Asp Glu Leu Leu Gly Glu Lys Pro Glu Ile Lys Gln Lys Trp Ala Ser
                  85                  90                  95    
 Arg Leu Leu Ala Lys Leu Arg Lys Asp Ile Arg Pro Glu Phe Arg Glu
             100                 105                 110        
 Asp Phe Arg Ala Gly Pro Ser Arg Gly Lys Lys Pro Pro Trp Leu Ala
         115                 120                 125            
 Leu Leu Ser Asn Pro Asp Gln Lys Gly Lys Ile Arg Arg Ile Asp Cys
     130                 135                 140                
 Leu Arg Gln Ala Asp Lys Val Trp Arg Leu Asp Leu Val Met Val Ile
 145                 150                 155                 160
 Leu Phe Lys Gly Gly Ser Pro Leu Glu Ser Thr Asp Gly Glu Arg Leu
                 165                 170                 175    
 Tyr Lys Ser Pro Gln Cys Ser Asn Pro Gly Leu Cys Val Gln Pro His
             180                 185                 190        
 His Ile Gly Val Thr Ile Lys Glu Leu Asp Leu Tyr Leu Ala Tyr Phe
         195                 200                 205            
 Cys Pro Thr Thr Pro Glu Ser Arg Arg Ser Asp Ser Ser Asn Gln His
     210                 215                 220                
 Arg Asp Ala Asp Ile Lys Pro Leu Pro Asn Gly His Leu Ser Phe Gln
 225                 230                 235                 240
 Asp Cys Tyr Val Thr Ser Gly Val Trp Asn Val Thr Glu Leu Val Arg
                 245                 250                 255    
 Val Ser Gln Thr Pro Val Ala Thr Ala Ser Gly Pro Asn Phe Ser Leu
             260                 265                 270        
 Ala Asp Leu Glu Ser Pro Ser Tyr Tyr Asn Ile Gln Pro Gly Xaa Pro
         275                 280                 285            
 Trp Gly Arg Arg Ser Ile Thr Ser Pro Pro Phe His Gln Ala Pro Pro
     290                 295                 300                
 Arg Arg Pro Lys Phe His Ser Met Asp Ser Ser Arg Trp Glu Ser Pro
 305                 310                 315                 320
 Val Asp Asp Val Phe Tyr Pro Gly Thr Ala Arg Ser Pro Ala Ala Ala
                 325                 330                 335    
 Ser Ser Gln Ser Ser Gly Trp Pro Asn Asp Val Asp Ala Gly Pro Ala
             340                 345                 350        
 Ser Ala Lys Lys Ser Gly Lys Leu Asp Phe Cys Ser Ala Leu Ser Ser
         355                 360                 365            
 Gln Gly Ser Ser Pro Arg Met Ala Phe Thr His His Pro Leu Pro Val
     370                 375                 380                
 Leu Ala Gly Val Arg Thr Gly Ser Pro Arg Val Thr Ala Xaa Ala Leu
 385                 390                 395                 400
 His Phe Pro Ser Arg Ser Phe Ile Gln Gln Ser Ser Arg Tyr Phe Arg
                 405                 410                 415    
 His Pro Thr Ile Arg Tyr His His His His Gly Gln Asp Ser Leu Lys
             420                 425                 430        
 Glu Phe Val Gln Phe Val Cys Ser Asp Gly Ser Val Gln Ala Thr Gly
         435                 440                 445            
 Gln His Ser Gln Arg Gln Ala Pro Ser Leu Pro Thr Gly Leu Ser Ala
     450                 455                 460                
 Ser Asp Pro Gly Thr Ala Thr Leu Met Asn Ile Pro Gln Gln Ser Gln
 465                 470                 475                 480
 Ser Trp Phe Leu
                



      <210> 3106
      <211> 873
      <212> PRT
      <213> Homo sapiens


      <400> 3106
 Asn Lys Asn Ile Leu Glu Val Pro Ser Ala Arg Thr Thr Arg Ile Met
   1               5                  10                  15    
 Gly Asp His Leu Asp Leu Leu Leu Gly Val Val Leu Met Ala Gly Pro
              20                  25                  30        
 Val Phe Gly Ile Pro Ser Cys Ser Phe Asp Gly Arg Ile Ala Phe Tyr
          35                  40                  45            
 Arg Phe Cys Asn Leu Thr Gln Val Pro Gln Val Leu Asn Thr Thr Glu
      50                  55                  60                
 Arg Leu Leu Leu Ser Phe Asn Tyr Ile Arg Thr Val Thr Ala Ser Ser
  65                  70                  75                  80
 Phe Pro Phe Leu Glu Gln Leu Gln Leu Leu Glu Leu Gly Ser Gln Tyr
                  85                  90                  95    
 Thr Pro Leu Thr Ile Asp Lys Glu Ala Phe Arg Asn Leu Pro Asn Leu
             100                 105                 110        
 Arg Ile Leu Asp Leu Gly Ser Ser Lys Ile Tyr Phe Leu His Pro Asp
         115                 120                 125            
 Ala Phe Gln Gly Leu Phe His Leu Phe Glu Leu Arg Leu Tyr Phe Cys
     130                 135                 140                
 Gly Leu Ser Asp Ala Val Leu Lys Asp Gly Tyr Phe Arg Asn Leu Lys
 145                 150                 155                 160
 Ala Leu Thr Arg Leu Asp Leu Ser Lys Asn Gln Ile Arg Ser Leu Tyr
                 165                 170                 175    
 Leu His Pro Ser Phe Gly Lys Leu Asn Ser Leu Lys Ser Ile Asp Phe
             180                 185                 190        
 Ser Ser Asn Gln Ile Phe Leu Val Cys Glu His Glu Leu Glu Pro Leu
         195                 200                 205            
 Gln Gly Lys Thr Leu Ser Phe Phe Ser Leu Ala Ala Asn Ser Leu Tyr
     210                 215                 220                
 Ser Arg Val Ser Val Asp Trp Gly Lys Cys Met Asn Pro Phe Arg Asn
 225                 230                 235                 240
 Met Val Leu Glu Ile Leu Asp Val Ser Gly Asn Gly Trp Thr Val Asp
                 245                 250                 255    
 Ile Thr Gly Asn Phe Ser Asn Ala Ile Ser Lys Ser Gln Ala Phe Ser
             260                 265                 270        
 Leu Ile Leu Ala His His Ile Met Gly Ala Gly Phe Gly Phe His Asn
         275                 280                 285            
 Ile Lys Asp Pro Asp Gln Asn Thr Phe Ala Gly Leu Ala Arg Ser Ser
     290                 295                 300                
 Val Arg His Leu Asp Leu Ser His Gly Phe Val Phe Ser Leu Asn Ser
 305                 310                 315                 320
 Arg Val Phe Glu Thr Leu Lys Asp Leu Lys Val Leu Asn Leu Ala Tyr
                 325                 330                 335    
 Asn Lys Ile Asn Lys Ile Ala Asp Glu Ala Phe Tyr Gly Leu Asp Asn
             340                 345                 350        
 Leu Gln Val Leu Asn Leu Ser Tyr Asn Leu Leu Gly Glu Leu Tyr Ser
         355                 360                 365            
 Ser Asn Phe Tyr Gly Leu Pro Lys Val Ala Tyr Ile Asp Leu Gln Lys
     370                 375                 380                
 Asn His Ile Ala Ile Ile Gln Asp Gln Thr Phe Lys Phe Leu Glu Lys
 385                 390                 395                 400
 Leu Gln Thr Leu Asp Leu Arg Asp Asn Ala Leu Thr Thr Ile His Phe
                 405                 410                 415    
 Ile Pro Ser Ile Pro Asp Ile Phe Leu Ser Gly Asn Lys Leu Val Thr
             420                 425                 430        
 Leu Pro Lys Ile Asn Leu Thr Ala Asn Leu Ile His Leu Ser Glu Asn
         435                 440                 445            
 Arg Leu Glu Asn Leu Asp Ile Leu Tyr Phe Leu Leu Arg Val Pro His
     450                 455                 460                
 Leu Gln Ile Leu Ile Leu Asn Gln Asn Arg Phe Ser Ser Cys Ser Gly
 465                 470                 475                 480
 Asp Gln Thr Pro Ser Glu Asn Pro Ser Leu Glu Gln Leu Phe Leu Gly
                 485                 490                 495    
 Glu Asn Met Leu Gln Leu Ala Trp Glu Thr Glu Leu Cys Trp Asp Val
             500                 505                 510        
 Phe Glu Gly Leu Ser His Leu Gln Val Leu Tyr Leu Asn His Asn Tyr
         515                 520                 525            
 Leu Asn Ser Leu Pro Pro Gly Val Phe Ser His Leu Thr Ala Leu Arg
     530                 535                 540                
 Gly Leu Ser Leu Asn Ser Asn Arg Leu Thr Val Leu Ser His Asn Asp
 545                 550                 555                 560
 Leu Pro Ala Asn Leu Glu Ile Leu Asp Ile Ser Arg Asn Gln Leu Leu
                 565                 570                 575    
 Ala Pro Asn Pro Asp Val Phe Val Ser Leu Ser Val Leu Asp Ile Thr
             580                 585                 590        
 His Asn Lys Phe Ile Cys Glu Cys Glu Leu Ser Thr Phe Ile Asn Trp
         595                 600                 605            
 Leu Asn His Thr Asn Val Thr Ile Ala Gly Pro Pro Ala Asp Ile Tyr
     610                 615                 620                
 Cys Val Tyr Pro Asp Ser Leu Ser Gly Val Ser Leu Phe Ser Leu Ser
 625                 630                 635                 640
 Thr Glu Gly Cys Asp Glu Glu Glu Val Leu Lys Ser Leu Lys Phe Ser
                 645                 650                 655    
 Leu Phe Ile Val Cys Thr Val Thr Leu Thr Leu Phe Leu Met Thr Ile
             660                 665                 670        
 Leu Thr Val Thr Lys Phe Arg Gly Phe Cys Phe Ile Cys Tyr Lys Thr
         675                 680                 685            
 Ala Gln Arg Leu Val Phe Lys Asp His Pro Gln Gly Thr Glu Pro Asp
     690                 695                 700                
 Met Tyr Lys Tyr Asp Ala Tyr Leu Cys Phe Ser Ser Lys Asp Phe Thr
 705                 710                 715                 720
 Trp Val Gln Asn Ala Leu Leu Lys His Leu Asp Thr Gln Tyr Ser Asp
                 725                 730                 735    
 Gln Asn Arg Phe Asn Leu Cys Phe Glu Glu Arg Asp Phe Val Pro Gly
             740                 745                 750        
 Glu Asn Arg Pro Ala Asn Ile Gln Asp Ala Ile Trp Asn Ser Arg Lys
         755                 760                 765            
 Ile Val Cys Leu Val Ser Arg His Phe Leu Arg Asp Gly Trp Cys Leu
     770                 775                 780                
 Glu Ala Phe Ser Tyr Ala Gln Gly Arg Cys Leu Ser Asp Leu Asn Ser
 785                 790                 795                 800
 Ala Leu Ile Met Val Val Val Gly Ser Leu Ser Gln Tyr Gln Leu Met
                 805                 810                 815    
 Lys His Gln Ser Ile Arg Gly Phe Val Gln Lys Gln Gln Tyr Leu Arg
             820                 825                 830        
 Trp Pro Glu Asp Leu Gln Asp Val Gly Trp Phe Leu His Lys Leu Ser
         835                 840                 845            
 Gln Gln Ile Leu Lys Lys Glu Lys Glu Lys Lys Lys Asp Asn Asn Ile
     850                 855                 860                
 Pro Leu Gln Thr Val Ala Thr Ile Ser
 865                 870            



      <210> 3107
      <211> 289
      <212> PRT
      <213> Homo sapiens


      <400> 3107
 Pro Thr Thr Gly Phe Pro Val Thr Asn Phe Pro Trp Asn Trp Pro Asp
   1               5                  10                  15    
 Gly Lys Pro Pro Ile Met Ile Leu Tyr Val Ser Lys Leu Asn Lys Ile
              20                  25                  30        
 Ile His Phe Pro Asp Phe Asp Lys Lys Ile Pro Val Lys Leu Phe Pro
          35                  40                  45            
 Leu Pro Leu Leu Tyr Val Gly Asn His Ile Ser Gly Leu Ser Ser Thr
      50                  55                  60                
 Ser Lys Leu Ser Leu Pro Met Phe Thr Val Leu Arg Lys Phe Thr Ile
  65                  70                  75                  80
 Pro Leu Thr Leu Leu Leu Glu Thr Ile Ile Leu Gly Lys Gln Tyr Ser
                  85                  90                  95    
 Leu Asn Ile Ile Leu Ser Val Phe Ala Ile Ile Leu Gly Ala Phe Ile
             100                 105                 110        
 Ala Ala Gly Ser Asp Leu Ala Phe Asn Leu Glu Gly Tyr Ile Phe Val
         115                 120                 125            
 Phe Leu Asn Asp Ile Phe Thr Ala Ala Asn Gly Val Tyr Thr Lys Gln
     130                 135                 140                
 Lys Met Asp Pro Lys Glu Leu Gly Lys Tyr Gly Val Leu Phe Tyr Asn
 145                 150                 155                 160
 Ala Cys Phe Met Ile Ile Pro Thr Leu Ile Ile Ser Val Ser Thr Gly
                 165                 170                 175    
 Asp Leu Gln Gln Ala Thr Glu Phe Asn Gln Trp Lys Asn Val Val Phe
             180                 185                 190        
 Ile Leu Gln Phe Leu Leu Ser Cys Phe Leu Gly Phe Leu Leu Met Tyr
         195                 200                 205            
 Ser Thr Val Leu Cys Ser Tyr Tyr Asn Ser Ala Leu Thr Thr Ala Val
     210                 215                 220                
 Val Gly Ala Ile Lys Asn Val Ser Val Ala Tyr Ile Gly Ile Leu Ile
 225                 230                 235                 240
 Gly Gly Asp Tyr Ile Phe Ser Leu Leu Asn Phe Val Gly Leu Asn Ile
                 245                 250                 255    
 Cys Met Ala Gly Gly Leu Arg Tyr Ser Phe Leu Thr Leu Ser Ser Gln
             260                 265                 270        
 Leu Lys Pro Lys Pro Val Gly Glu Glu Asn Ile Cys Leu Asp Leu Lys
         275                 280                 285            
 Ser
    



      <210> 3108
      <211> 148
      <212> PRT
      <213> Homo sapiens


      <400> 3108
 Gly Arg Pro Asp Arg Ser Glu Leu Val Arg Met His Ile Leu Glu Glu
   1               5                  10                  15    
 Thr Phe Ala Glu Pro Ser Leu Gln Ala Thr Gln Met Lys Leu Lys Arg
              20                  25                  30        
 Ala Arg Leu Ala Asp Asp Leu Asn Glu Lys Ile Ala Gln Arg Pro Gly
          35                  40                  45            
 Pro Met Glu Leu Val Glu Lys Asn Ile Leu Pro Val Asp Ser Ser Val
      50                  55                  60                
 Lys Glu Ala Ile Ile Gly Val Gly Lys Glu Asp Tyr Pro His Thr Gln
  65                  70                  75                  80
 Gly Asp Phe Ser Phe Asp Glu Asp Ser Ser Asp Ala Leu Ser Pro Asp
                  85                  90                  95    
 Gln Pro Ala Ser Gln Glu Ser Gln Gly Ser Ala Ala Ser Pro Ser Glu
             100                 105                 110        
 Pro Lys Val Ser Glu Ser Pro Ser Pro Val Thr Thr Asn Thr Pro Ala
         115                 120                 125            
 Gln Phe Ala Ser Val Ser Pro Thr Val Pro Glu Phe Leu Lys Thr Pro
     130                 135                 140                
 Pro Thr Ala Asp
 145            



      <210> 3109
      <211> 266
      <212> PRT
      <213> Homo sapiens

      <220>
      <221> misc_feature
      <222> (1)...(266)
      <223> Xaa = any amino acid or symbol as shown in the table 8 as set forth in Example 2


      <400> 3109
 Ser Glu Thr Ala Gln Gln Ile Ile Asp Arg Leu Arg Val Lys Leu Ala
   1               5                  10                  15    
 Lys Glu Pro Gly Ala Asn Leu Phe Leu Met Ala Val Gln Asp Ile Arg
              20                  25                  30        
 Val Gly Gly Arg Gln Ser Asn Ala Ser Tyr Gln Tyr Thr Leu Leu Ser
          35                  40                  45            
 Asp Asp Leu Ala Ala Leu Arg Glu Trp Glu Pro Lys Ile Arg Lys Lys
      50                  55                  60                
 Leu Ala Thr Leu Pro Glu Leu Ala Asp Val Asn Ser Asp Gln Gln Asp
  65                  70                  75                  80
 Asn Gly Ala Glu Met Asn Leu Val Tyr Asp Arg Asp Thr Met Ala Arg
                  85                  90                  95    
 Leu Gly Ile Asp Val Gln Ala Ala Asn Ser Leu Leu Asn Asn Ala Phe
             100                 105                 110        
 Gly Gln Arg Gln Ile Ser Thr Ile Tyr Gln Pro Met Asn Gln Tyr Lys
         115                 120                 125            
 Val Val Met Glu Val Asp Pro Arg Tyr Thr Gln Asp Ile Ser Ala Leu
     130                 135                 140                
 Glu Lys Met Phe Val Ile Asn Asn Glu Gly Lys Ala Ile Pro Leu Ser
 145                 150                 155                 160
 Tyr Phe Ala Lys Trp Gln Pro Ala Asn Ala Pro Leu Ser Val Asn His
                 165                 170                 175    
 Gln Gly Leu Ser Ala Ala Leu Thr Ile Ser Phe Asn Leu Pro Thr Gly
             180                 185                 190        
 Lys Ser Leu Ser Asp Ala Ser Ala Ala Ile Asp Arg Ala Met Ser Gln
         195                 200                 205            
 Leu Gly Val Pro Ser Thr Val Arg Gly Ser Phe Ala Gly Pro Ala Gln
     210                 215                 220                
 Val Phe Gln Glu Thr Met Asn Ser Gln Val Ile Leu Ile Ile Ala Ala
 225                 230                 235                 240
 Ile Ala Thr Val Tyr Ile Val Leu Gly Ile Pro Tyr Glu Arg Tyr Val
                 245                 250                 255    
 His Pro Pro Thr Ile Leu Leu Xaa Arg Pro
             260                 265    



      <210> 3110
      <211> 323
      <212> PRT
      <213> Homo sapiens


      <400> 3110
 Met Trp Ala Leu Phe Met Ile Arg Asn Val Lys Lys Gln Arg Pro Val
   1               5                  10                  15    
 Asn Leu Asp Leu Gln Thr Ile Arg Phe Pro Ile Thr Ala Ile Ala Ser
              20                  25                  30        
 Ile Leu His Arg Val Ser Gly Val Ile Thr Phe Val Ala Val Gly Ile
          35                  40                  45            
 Leu Leu Trp Leu Leu Glu Tyr Arg Leu Ser Tyr Leu Lys Gly Ser Ser
      50                  55                  60                
 Lys Leu Arg Asp Tyr Gly Gln Leu Leu Thr Leu Glu Ile Pro Ala Ala
  65                  70                  75                  80
 Leu Leu Pro Ile His Thr Gly Ile Val Asn Gln Asn Ile Asn Cys Thr
                  85                  90                  95    
 Glu Thr Leu Thr Ala Ser Ser Asp Asn Leu Leu Arg Arg Ala Phe Cys
             100                 105                 110        
 Gly Asp Thr His Leu His Glu Val His Leu Asn Thr Leu Phe Phe Asn
         115                 120                 125            
 His Phe Leu Cys Phe Ala Val Ile Phe Asp Glu Thr Arg Asn Lys Asp
     130                 135                 140                
 Ile Cys Ala Thr Ser Gly Gln His Ala His Phe Val Asp Lys Lys Arg
 145                 150                 155                 160
 Lys Arg Glu Leu Leu Ser His Met Ile Gly Lys Gly Asn Trp Gln Gln
                 165                 170                 175    
 Val Leu Val Phe Thr Arg Thr Lys His Gly Ala Asn His Leu Ala Glu
             180                 185                 190        
 Gln Leu Asn Lys Asp Gly Ile Arg Ser Ala Ala Ile His Gly Asn Lys
         195                 200                 205            
 Ser Gln Gly Ala Arg Thr Arg Ala Leu Ala Asp Phe Lys Ser Gly Asp
     210                 215                 220                
 Ile Arg Val Leu Val Ala Thr Asp Ile Ala Ala Arg Gly Leu Asp Ile
 225                 230                 235                 240
 Glu Glu Leu Pro His Val Val Asn Tyr Glu Leu Pro Asn Val Pro Glu
                 245                 250                 255    
 Asp Tyr Val His Arg Ile Gly Arg Thr Gly Arg Ala Ala Ala Thr Gly
             260                 265                 270        
 Glu Ala Leu Ser Leu Val Arg Ser Phe Phe Asp Trp Cys Asp Asp Cys
         275                 280                 285            
 Ala Ala Ala Gly Gly Met Gly Asn Arg Asn Ala Gln Leu Ala Asp Gly
     290                 295                 300                
 Ile Tyr His Leu Arg Cys Ile Glu Leu Tyr Leu Gly Asp Gly Met Ala
 305                 310                 315                 320
 Asp Phe Leu
            



      <210> 3111
      <211> 1766
      <212> PRT
      <213> Homo sapiens


      <400> 3111
 Met Ala Trp Leu Leu Ile Ile Tyr Ile Leu Pro Leu Val Gly Ile Ile
   1               5                  10                  15    
 Ala Tyr Leu Ala Val Gly Glu Leu His Leu Gly Lys Arg Arg Ala Glu
              20                  25                  30        
 Ala His Leu Arg Leu Trp Pro Ser Thr Ala Lys Trp Leu Asn Asp Leu
          35                  40                  45            
 Lys Ala Cys Lys His Ile Phe Ala Glu Glu Asn Ser Ser Val Ala Ala
      50                  55                  60                
 Pro Leu Phe Lys Leu Cys Ile Ala Ser Ser Gly Asp Ser Leu Glu Val
  65                  70                  75                  80
 Lys Gly Asn Gln Leu Gln Leu Met Thr Glu Ser Asp Asp Val Met Gln
                  85                  90                  95    
 Ala Leu Ile Arg Asp Ile Gln Leu Ala Arg His Asn Ile Glu Met Val
             100                 105                 110        
 Phe Tyr Ile Trp Gln Pro Gly Gly Met Gly Gly Pro Val Arg Ile Pro
         115                 120                 125            
 Arg Leu Ser Trp Cys Tyr Val Arg His Gln Met Lys Arg Gln Pro Gly
     130                 135                 140                
 Phe Ser Arg Gln Ser Ala Gly Gly Lys Thr Gly Gly Leu Arg Asp Leu
 145                 150                 155                 160
 Asp Pro Arg Arg Tyr Leu Ser Leu Leu Leu Gly Ser Leu Ile Ile His
                 165                 170                 175    
 Ile Lys Pro Arg Asn Phe Trp Phe Tyr Leu Leu His Thr Glu Thr Gln
             180                 185                 190        
 Ile Thr Ser His Gly Ser Thr His Leu Tyr Ala Asp Pro Ala Thr Leu
         195                 200                 205            
 Gln His Phe Arg Phe Cys Arg Ile Ile Arg Arg Ala Gly Thr Phe Thr
     210                 215                 220                
 Ile Cys Pro Arg Asp Gln Ala Phe Ala Phe Asp Phe Gln Gln Asn Gln
 225                 230                 235                 240
 His Asp Leu Asn Leu Thr Trp Gln Ile Lys Asp Gly Tyr Tyr Leu Tyr
                 245                 250                 255    
 Arg Lys Gln Ile Arg Ile Thr Pro Glu His Ala Lys Ile Ala Asp Val
             260                 265                 270        
 Gln Leu Pro Gln Arg Pro Gly Met Lys Met Ser Phe Thr Gln Lys Gln
         275                 280                 285            
 Asp Leu Pro Ala Ser Ala Asp Ala Ser Arg His His Gln Pro Gly Asn
     290                 295                 300                
 Ala Gly Ala Arg Phe Leu Ser Lys Thr Leu Tyr Gly Ala Leu Glu His
 305                 310                 315                 320
 Asn Phe Thr Asp Ala Trp Ser Gly Phe Val Arg Gly Tyr Gly Tyr Asp
                 325                 330                 335    
 Asn Arg Thr Asn Tyr Asp Ala Tyr Tyr Ser Pro Gly Ser Pro Leu Leu
             340                 345                 350        
 Asp Thr Arg Lys Leu Tyr Ser Gln Ser Trp Asp Ala Gly Leu Arg Tyr
         355                 360                 365            
 Asn Gly Glu Leu Ile Lys Ser Gln Leu Ile Thr Ser Tyr Ser His Ser
     370                 375                 380                
 Lys Asp Tyr Asn Tyr Asp Pro His Tyr Gly Arg Tyr Asp Ser Ser Ala
 385                 390                 395                 400
 Thr Leu Asp Glu Met Lys Gln Tyr Thr Val Gln Trp Ala Asn Asn Val
                 405                 410                 415    
 Ile Val Gly His Gly Ser Ile Gly Ala Gly Val Asp Trp Gln Lys Gln
             420                 425                 430        
 Thr Thr Thr Pro Gly Thr Gly Tyr Val Glu Asp Gly Tyr Asp Gln Arg
         435                 440                 445            
 Asn Thr Gly Ile Tyr Leu Thr Gly Leu Gln Gln Val Gly Asp Phe Thr
     450                 455                 460                
 Phe Glu Cys Ala Ala Arg Ser Asp Asp Asn Ser Gln Phe Gly Arg His
 465                 470                 475                 480
 Gly Thr Trp Gln Thr Ser Ala Gly Trp Glu Phe Ile Glu Gly Tyr Arg
                 485                 490                 495    
 Phe Ile Ala Ser Tyr Gly Thr Ser Tyr Lys Ala Pro Asn Leu Gly Gln
             500                 505                 510        
 Leu Tyr Gly Phe Tyr Gly Asn Pro Asn Leu Asp Pro Glu Lys Ser Lys
         515                 520                 525            
 Gln Leu Glu Gly Ala Phe Glu Cys Leu Thr Ala Gly Val Asn Trp Arg
     530                 535                 540                
 Ile Ser Gly Tyr Arg Asn Asp Val Ser Asp Leu Ile Asp Tyr Asp Asp
 545                 550                 555                 560
 His Thr Leu Glu Tyr Leu Gln Leu Arg Thr His Pro Gly Arg Val Ser
                 565                 570                 575    
 Thr Val Lys Val Phe Tyr Cys Arg Asn Phe Glu Lys Asn Cys Ala Asp
             580                 585                 590        
 Leu Thr Asn Ile Ile Arg Lys Gly Gly Thr Met Lys Ala Ala Val Val
         595                 600                 605            
 Thr Lys Asp His His Val Asp Val Thr Tyr Lys Thr Leu Arg Ser Leu
     610                 615                 620                
 Lys His Gly Glu Ala Leu Leu Lys Met Gln Cys Cys Gly Val Cys His
 625                 630                 635                 640
 Thr Asp Leu His Val Lys Asn Gly Asp Phe Gly Asp Lys Thr Gly Val
                 645                 650                 655    
 Ile Leu Gly His Glu Gly Ile Gly Val Val Ala Glu Val Gly Pro Gly
             660                 665                 670        
 Val Thr Ser Leu Lys Pro Gly Asp Arg Ala Ser Val Ala Trp Phe Tyr
         675                 680                 685            
 Glu Gly Cys Gly His Cys Glu Tyr Cys Asn Ser Gly Asn Glu Thr Leu
     690                 695                 700                
 Cys Arg Ser Val Lys Asn Ala Gly Tyr Ser Val Asp Gly Gly Met Ala
 705                 710                 715                 720
 Glu Glu Cys Ile Val Val Ala Asp Tyr Ala Val Lys Val Pro Asp Gly
                 725                 730                 735    
 Leu Asp Ser Ala Ala Ala Ser Ser Ile Thr Cys Ala Gly Val Thr Thr
             740                 745                 750        
 Tyr Lys Ala Val Lys Leu Ser Lys Ile Arg Pro Gly Gln Trp Ile Ala
         755                 760                 765            
 Ile Tyr Gly Leu Gly Gly Leu Gly Asn Leu Ala Leu Gln Tyr Ala Lys
     770                 775                 780                
 Asn Val Phe Asn Ala Lys Val Ile Ala Ile Asp Val Asn Asp Glu Gln
 785                 790                 795                 800
 Leu Lys Leu Ala Thr Glu Met Gly Ala Asp Leu Ala Ile Asn Ser His
                 805                 810                 815    
 Thr Glu Asp Ala Ala Lys Ile Val Gln Glu Lys Thr Gly Gly Ala His
             820                 825                 830        
 Ala Ala Val Val Thr Ala Leu Met Leu Ser Val Gln Ala Val Val Leu
         835                 840                 845            
 Trp Leu Ser Val Thr Ala Gly Val Tyr Glu Pro Gly Tyr Pro Arg Leu
     850                 855                 860                
 Val Leu Asp Cys Ile Glu Val Val Gly Leu Ile Leu Cys Asn Met Met
 865                 870                 875                 880
 Ser Ile Pro Arg Arg Arg Ser Val Met Ala Asn His Arg Gly Gly Ser
                 885                 890                 895    
 Gly Asn Phe Ala Glu Asp Arg Glu Arg Ala Ser Glu Ala Gly Lys Lys
             900                 905                 910        
 Gly Gly Gln His Ser Val Gly Asn Phe Lys Asn Asp Pro Gln Arg Ala
         915                 920                 925            
 Ser Glu Ala Ala Arg Gln Lys Ala Ile Thr Ala Gly Tyr Pro Val Val
     930                 935                 940                
 Asp Thr Asp Asp Lys Cys Val Arg Arg Tyr Ala Thr Asn Arg Lys His
 945                 950                 955                 960
 Leu Ser Lys His His Phe Asn Pro Ala Leu Phe Gly Pro Met Leu Pro
                 965                 970                 975    
 Tyr Pro Gly Phe Leu Asn Ser His Phe Gln Leu Thr Cys Leu Gln Tyr
             980                 985                 990        
 Lys Asn Asp Tyr Pro Asp Asp Tyr Asn Glu Lys Ala Glu Gln Glu Leu
         995                1000                1005            
 Thr Ala Asn Glu Ile Phe Met Gln Tyr Val Leu Pro Asn Lys Leu Leu
    1010                1015                1020                
 Trp Tyr Ile Ala Ile Ala Asn Val Phe Val Tyr Leu Leu Arg Tyr Gly
1025                1030                1035                1040
 Ile Leu Asp Trp Ser Pro Thr Tyr Leu Lys Glu Val Lys His Phe Ala
                1045                1050                1055    
 Leu Asp Lys Ser Ser Trp Ala Tyr Phe Leu Tyr Glu Tyr Ala Gly Ile
            1060                1065                1070        
 Pro Gly Thr Leu Leu Leu Pro Trp Gln Pro Trp Gly Asn Arg Arg Phe
        1075                1080                1085            
 Leu Tyr Asp Thr Gly Asp His Arg Asp Tyr Arg Leu Leu Asp Glu Pro
    1090                1095                1100                
 Gly Ser Asn Pro Thr Val Asp Met Ile Cys Met Ile Val Ile Gly Phe
1105                1110                1115                1120
 Leu Ile Asn Gly Pro Val Met Leu Ile Gly Leu His Ala Leu Glu Leu
                1125                1130                1135    
 Ala Pro Lys Lys Ala Ala Gly Thr Ala Ala Gly Phe Thr Gly Leu Phe
            1140                1145                1150        
 Gly Tyr Leu Gly Arg Ser Val Ala Pro Ala Arg Phe Val Gly Tyr Thr
        1155                1160                1165            
 Trp Thr Ser Ser Ala Gly Met Ala Ala Leu Trp Ser Ile Tyr Asn Val
    1170                1175                1180                
 Pro Leu Val Thr Ile Ile Ile Met Gly Phe Phe Phe Pro Arg Ile Pro
1185                1190                1195                1200
 Ala Leu Ala Ala Lys Val Ala Met Gly Ile Gly Ile Ile Ser Tyr Ile
                1205                1210                1215    
 Thr Ile Asn Tyr Leu Val Lys Phe Asp Phe His Phe Leu Tyr Val Leu
            1220                1225                1230        
 Ala Cys Thr Phe Cys Ile Asn Val Val Val Met Leu Val Ile Gly Phe
        1235                1240                1245            
 Ile Lys Pro Arg Ala Thr Pro Phe Thr Phe Lys Asp Ala Phe Ala Val
    1250                1255                1260                
 Asp Met Lys Pro Trp Lys Asn Val Lys Ile Ala Ser Ile Gly Ile Leu
1265                1270                1275                1280
 Phe Ala Met Ile Gly Val Tyr Ala Gly Leu Ala Glu Phe Gly Gly Tyr
                1285                1290                1295    
 Gly Thr Arg Cys Gly Lys Pro Arg Asn Thr Gln Asn Ile Asp Asn Leu
            1300                1305                1310        
 Ala Ala Glu Gly Ile Arg Leu Ile Pro Pro Thr Pro Phe Thr Gly Cys
        1315                1320                1325            
 Thr Pro Glu Arg Ala Gly Leu Leu Pro Val Ser Ser Leu Thr Val Pro
    1330                1335                1340                
 Pro Leu Asp Asn Asn Phe Ala Gln Gln Lys His Pro His Met Gly Pro
1345                1350                1355                1360
 Tyr Leu Arg Arg Pro Thr Asp His Pro Ala Leu Glu Asn Val Asn Phe
                1365                1370                1375    
 Ala Leu Lys Pro Gly Gln Met Leu Gly Ile Cys Gly Pro Thr Gly Ser
            1380                1385                1390        
 Gly Lys Ser Thr Leu Leu Ser Leu Ile Gln Arg His Phe Asp Val Ser
        1395                1400                1405            
 Glu Gly Asp Ile Arg Phe His Asp Ile Pro Leu Thr Lys Leu Gln Leu
    1410                1415                1420                
 Asp Ser Trp Arg Ser Ala Trp Arg Tyr Val Ser Gln Thr Pro Phe Leu
1425                1430                1435                1440
 Phe Ser Asp Thr Val Ala Asn Asn Ile Ala Leu Gly Cys Pro Asn Ala
                1445                1450                1455    
 Thr Gln Gln Glu Ile Glu His Val Ala Arg Leu Ala Ser Val His Asp
            1460                1465                1470        
 Asp Ile Leu Arg Leu Pro Gln Val Thr Asp Thr Glu Val Gly Glu Arg
        1475                1480                1485            
 Gly Val Met Pro Ser Gly Gly Gln Lys Gln Arg Ile Ser Ile Ala Arg
    1490                1495                1500                
 Ala Leu Leu Val Asn Ala Glu Ile Leu Ile Leu Asp Asp Ala Leu Ser
1505                1510                1515                1520
 Ala Val Asp Gly Arg Thr Glu His Gln Ile Leu His Asn Leu Arg Gln
                1525                1530                1535    
 Trp Gly Gln Gly Arg Thr Val Ile Ile Ser Ala His Arg Leu Ser Ala
            1540                1545                1550        
 Leu Thr Glu Ala Ser Glu Ile Ile Val Met Gln His Gly His Ile Ala
        1555                1560                1565            
 Gln Leu Ala Ile Met Met Cys Trp Thr Thr Lys Arg Leu Phe Arg Met
    1570                1575                1580                
 Ala Ile Glu Gln Gln Gly Asn Val Ser Leu Arg Ser Gly Arg His Asn
1585                1590                1595                1600
 Gly Asp Arg Phe Arg Thr Phe Thr Gln Arg Phe Arg His Gln Leu Tyr
                1605                1610                1615    
 Arg Arg Thr Val Leu Arg Cys Glu Cys Arg Phe Arg Ser Pro Asp Ser
            1620                1625                1630        
 Pro Leu Tyr Gly Lys Ala His Phe Val Gly His His His His Gly His
        1635                1640                1645            
 Ser Phe Val Arg Gln Phe His His His Val Gln Tyr Ser Leu Ile Ile
    1650                1655                1660                
 Ser Gly Ser Ser Ala Asp Val Val Arg Arg Lys Leu Ile Gly Val Ser
1665                1670                1675                1680
 Arg Lys Pro Asp Thr Leu Gln Gln Phe Gln Gly Phe Phe Thr Ser Arg
                1685                1690                1695    
 Arg Phe Ile Ala Phe Lys His Phe His Leu Arg Gln Gly Gln Val Phe
            1700                1705                1710        
 Asp Asn Arg Gln Met Arg Glu Gln Leu Glu Met Leu Glu Tyr His Pro
        1715                1720                1725            
 Asp Ala Gly Thr Gln Leu Cys Gln Ile Gly Phe Leu Val Val Asn His
    1730                1735                1740                
 Asp Thr Ile Asp Gly Asp Phe Thr Leu Leu His Arg Phe Glu Ala Val
1745                1750                1755                1760
 Asp Gly Phe Asn Gln Arg
                1765    



      <210> 3112
      <211> 332
      <212> PRT
      <213> Homo sapiens


      <400> 3112
 Met Ala Gly Phe Leu Gly Leu Ala Leu Leu Arg Arg Pro Leu Arg Thr
   1               5                  10                  15    
 Leu Phe Pro Arg Thr Pro Ser Pro Leu Val Gln Ala Pro Val Gly Pro
              20                  25                  30        
 Thr Ser Ser Arg Ile Gln Pro Val Arg Cys Val Lys Pro Arg Cys Phe
          35                  40                  45            
 Pro Ile Ala Ile Ser Gly Phe Asp Ser Gly Phe Ser Thr Phe Ala Gln
      50                  55                  60                
 Gly Phe Val Ala Leu Gly Ser Phe Arg Leu Ser Tyr Ile Thr Phe Tyr
  65                  70                  75                  80
 Ala Leu Ile Ala Val Ala Phe Val Trp Val Leu Trp Asn Lys Thr Arg
                  85                  90                  95    
 Phe Gly Lys Asn Ile Phe Ala Ile Gly Gly Asn Pro Glu Ala Ala Lys
             100                 105                 110        
 Val Ser Gly Val Asn Val Gly Leu Asn Leu Leu Met Ile Tyr Ala Leu
         115                 120                 125            
 Ser Gly Val Phe Tyr Ala Phe Gly Gly Met Leu Glu Ala Gly Arg Ile
     130                 135                 140                
 Gly Ser Ala Thr Asn Asn Leu Gly Phe Met Tyr Glu Leu Asp Ala Ile
 145                 150                 155                 160
 Ala Ala Cys Val Val Gly Gly Val Ser Phe Ser Gly Gly Val Gly Thr
                 165                 170                 175    
 Val Ile Gly Val Val Thr Gly Val Ile Ile Phe Thr Val Ile Asn Tyr
             180                 185                 190        
 Gly Leu Thr Tyr Ile Gly Val Asn Pro Tyr Trp Gln Tyr Ile Ile Lys
         195                 200                 205            
 Gly Ala Ile Ile Ile Phe Ala Val Ala Leu Asp Ser Leu Lys Tyr Ala
     210                 215                 220                
 Arg Arg Ile Arg Arg Ser Arg Arg Ile Arg Gln Trp Cys Thr Asn Ala
 225                 230                 235                 240
 Gly Tyr Leu His Gln Arg Pro His Asn Leu Gln Leu Gln Leu Ile Arg
                 245                 250                 255    
 His Phe Val Ile Arg Gln His Met Gln Pro Arg Arg Lys Gln Pro Cys
             260                 265                 270        
 Ile Thr Arg Gln Gln Arg Ala Gln Leu Arg Trp His Gln Gln His Arg
         275                 280                 285            
 Val Phe Pro Arg Arg Phe His Leu Leu Phe His Leu Trp His Arg Thr
     290                 295                 300                
 Leu Glu Leu Val Glu His Ile Arg Ile Asp Arg His Ala Val Glu His
 305                 310                 315                 320
 His Phe Pro Ala Leu Leu Arg Leu Ile His His Ser
                 325                 330        



      <210> 3113
      <211> 101
      <212> PRT
      <213> Homo sapiens

      <220>
      <221> misc_feature
      <222> (1)...(101)
      <223> Xaa = any amino acid or symbol as shown in the table 8 as set forth in Example 2


      <400> 3113
 Ser Ile Arg Arg Pro Lys Arg Ala Arg Pro Ile Arg Ile Lys Lys Ile
   1               5                  10                  15    
 Pro Glu Gln Gln Gly Pro Gln Pro Ala Val Leu Pro Val Gln Thr Val
              20                  25                  30        
 Ala Thr Arg Asp Arg Glu Leu Pro Gln Met Pro Pro Val Gly Pro Glu
          35                  40                  45            
 Thr Leu Lys Arg Asp Pro Pro Val Arg Ala Met Thr Ile Pro Ala Thr
      50                  55                  60                
 Ala Ala Val Tyr Lys Pro Tyr Trp Gly Ala Thr Pro Leu Pro Ile Ala
  65                  70                  75                  80
 Lys Pro Ser Pro Ala Gly Xaa Gln Xaa Ser Arg Arg Phe Ser Lys Gly
                  85                  90                  95    
 Tyr Phe Gly Phe Asp
             100    



      <210> 3114
      <211> 319
      <212> PRT
      <213> Homo sapiens


      <400> 3114
 Pro Ser Arg Ala Gly His Leu Pro Pro Lys Ile Lys Ser Ser Met Ala
   1               5                  10                  15    
 Gly Thr Thr Pro Cys Leu Ser Ile Met Val Arg Gln Arg Lys Pro Leu
              20                  25                  30        
 Val Pro Ala Pro Leu Tyr Gln Gly Met Arg Asp Gly Lys Ile Val Arg
          35                  40                  45            
 Phe Glu Glu Ile Thr Arg Thr Pro Leu Glu Val Gln Asp Cys Leu Leu
      50                  55                  60                
 Ala Ser Ala Leu Ala Leu Gly Leu Ala Leu Met Gly Asn Ala Gln Ala
  65                  70                  75                  80
 Val Thr Thr Ile Pro Phe Trp His Ser Met Glu Gly Glu Leu Gly Lys
                  85                  90                  95    
 Glu Val Asp Ser Leu Ala Gln Arg Phe Asn Ala Glu Asn Pro Asp Tyr
             100                 105                 110        
 Lys Ile Val Pro Thr Tyr Lys Gly Asn Tyr Glu Gln Asn Leu Ser Ala
         115                 120                 125            
 Gly Ile Ala Ala Phe Arg Thr Gly Asn Ala Pro Thr Tyr Phe Ala Gly
     130                 135                 140                
 His Ile Met Gln Ala Cys Gly Val Ala Leu Ser Ala Thr Ile Tyr Phe
 145                 150                 155                 160
 Ile Arg Arg Lys Val Val Ser Leu Ser Asp Gln Lys Leu Asn Ile Ala
                 165                 170                 175    
 Met Thr Phe Val Gly Ser Met Ser Gly Ala Leu Leu Val Gln Tyr Val
             180                 185                 190        
 Gln Ala Asp Val Leu Arg Gln Ile Leu Pro Ile Leu Val Ile Cys Ile
         195                 200                 205            
 Gly Leu Tyr Phe Leu Leu Met Pro Lys Leu Gly Glu Glu Asp Arg Gln
     210                 215                 220                
 Arg Arg Met Tyr Gly Leu Pro Phe Ala Leu Ile Ala Gly Gly Cys Val
 225                 230                 235                 240
 Gly Phe Tyr Asp Gly Phe Phe Gly Pro Ala Ala Gly Ser Phe Tyr Ala
                 245                 250                 255    
 Leu Ala Phe Val Thr Leu Cys Gly Phe Asn Leu Ala Lys Ala Thr Ala
             260                 265                 270        
 His Ala Lys Leu Leu Asn Ala Thr Ser Asn Ile Gly Gly Leu Leu Leu
         275                 280                 285            
 Phe Ile Leu Gly Gly Lys Val Ile Trp Ala Thr Gly Phe Val Met Leu
     290                 295                 300                
 Val Gly Gln Phe Leu Gly Ala Pro His Gly Val Pro Thr Cys Val
 305                 310                 315                



      <210> 3115
      <211> 127
      <212> PRT
      <213> Homo sapiens


      <400> 3115
 Met Leu Arg Phe Tyr Leu Ile Ala Gly Gly Ile Pro Leu Ile Ile Cys
   1               5                  10                  15    
 Gly Ile Thr Ala Ala Val Asn Ile His Asn Tyr Arg Asp His Ser Pro
              20                  25                  30        
 Tyr Cys Trp Leu Val Trp Arg Pro Ser Leu Gly Ala Phe Tyr Ile Pro
          35                  40                  45            
 Val Ala Leu Ile Leu Leu Ile Thr Trp Ile Tyr Phe Leu Cys Ala Gly
      50                  55                  60                
 Leu Arg Leu Arg Gly Pro Leu Ala Gln Asn Pro Lys Ala Gly Asn Ser
  65                  70                  75                  80
 Arg Ala Ser Leu Glu Ala Gly Glu Glu Leu Arg Gly Ser Thr Arg Leu
                  85                  90                  95    
 Arg Gly Ser Gly Pro Leu Leu Ser Asp Ser Gly Ser Leu Leu Ala Thr
             100                 105                 110        
 Gly Ser Ala Arg Val Gly Thr Pro Gly Pro Pro Glu Asp Gly Asp
         115                 120                 125        



      <210> 3116
      <211> 79
      <212> PRT
      <213> Homo sapiens


      <400> 3116
 Met Ile Gln Leu Phe Phe Val Leu Tyr Gly Ile Leu Ala Leu Ala Phe
   1               5                  10                  15    
 Leu Ser Gly Tyr Tyr Val Thr Leu Ala Ala Gln Ile Leu Ala Val Leu
              20                  25                  30        
 Leu Pro Pro Val Met Leu Leu Ile Asp Gly Asn Val Ala Tyr Trp His
          35                  40                  45            
 Asn Thr Arg Arg Val Glu Phe Trp Asn Gln Met Lys Leu Leu Gly Glu
      50                  55                  60                
 Ser Val Gly Ile Phe Gly Thr Ala Val Ile Leu Ala Thr Asp Gly
  65                  70                  75                



      <210> 3117
      <211> 332
      <212> PRT
      <213> Homo sapiens


      <400> 3117
 Met Ser Arg Val Ala Lys Ala Pro Val Val Val Pro Ala Gly Val Asp
   1               5                  10                  15    
 Val Lys Ile Asn Gly Gln Val Ile Thr Ile Lys Gly Lys Asn Gly Glu
              20                  25                  30        
 Leu Thr Arg Thr Leu Asn Asp Ala Val Glu Val Lys His Ala Asp Asn
          35                  40                  45            
 Thr Leu Thr Phe Gly Pro Arg Asp Gly Tyr Ala Asp Gly Trp Ala Gln
      50                  55                  60                
 Ala Gly Thr Ala Arg Ala Leu Leu Asn Ser Met Val Ile Gly Val Thr
  65                  70                  75                  80
 Glu Gly Phe Thr Lys Lys Leu Gln Leu Val Gly Val Gly Tyr Arg Ala
                  85                  90                  95    
 Ala Val Lys Gly Asn Val Ile Asn Leu Ser Leu Ala Ile Leu Gln Thr
             100                 105                 110        
 Ser Thr Gln Gly Ser Glu Val Cys Gly Pro Tyr Leu Gly Ile Gln Arg
         115                 120                 125            
 Ile Ala Pro Thr Ser Gln Phe Pro Lys Pro Ser Ala Thr Thr Glu Asp
     130                 135                 140                
 Ala Ala Ser Lys Ile Ala Leu Leu Ser Val Glu Leu Ser Ser Ala Leu
 145                 150                 155                 160
 Asp Ser Ile Asp Val Asn Lys Thr Thr Thr Asp Val Ser Ile Leu Asn
                 165                 170                 175    
 Arg Ser Ile Ile Thr Pro Gly Asn Asn Val Leu Val Asn Asn Thr Gly
             180                 185                 190        
 Gly Asp Leu Asn Ile Ile Ser Ser Asp Ser Ile Leu Asn Gly Ala Thr
         195                 200                 205            
 Lys Leu Val Ser Gly Thr Thr Thr Leu Lys Leu Ser Glu Asn Thr Ile
     210                 215                 220                
 Trp Asn Met Lys Asp Asp Ser Val Val Thr His Leu Thr Asn Ser Asp
 225                 230                 235                 240
 Ser Ile Ile Asn Leu Ser Tyr Asp Asp Gly Gln Thr Phe Thr Gln Gly
                 245                 250                 255    
 Lys Thr Leu Thr Val Lys Gly Asn Tyr Val Gly Asn Asn Gly Gln Leu
             260                 265                 270        
 Asn Ile Arg Thr Val Leu Gly Asp Asp Lys Ser Ala Thr Asp Arg Leu
         275                 280                 285            
 Ile Val Glu Gly Asn Thr Ser Gly Ser Thr Thr Val Tyr Val Lys Asn
     290                 295                 300                
 Ala Gly Gly Ser Gly Ala Ala Thr Leu Asn Gly Ile Glu Leu Ile Thr
 305                 310                 315                 320
 Val Asn Gly Asp Glu Ser Pro Ala Asp Ala Phe Arg
                 325                 330        



      <210> 3118
      <211> 220
      <212> PRT
      <213> Homo sapiens


      <400> 3118
 Pro Leu Ser Ala Val Ala Arg Pro Ala Arg Ser Ser Asp Pro Leu Arg
   1               5                  10                  15    
 Ser Ala Pro Leu Gly Pro Ala Pro Pro Val Asn Met Ile Arg Cys Gly
              20                  25                  30        
 Leu Ala Cys Glu Arg Cys Arg Trp Ile Leu Pro Leu Leu Leu Leu Ser
          35                  40                  45            
 Ala Ile Ala Phe Asp Ile Ile Ala Leu Ala Gly Arg Gly Trp Leu Gln
      50                  55                  60                
 Ser Ser Asp His Gly Gln Thr Ser Ser Leu Trp Trp Lys Cys Ser Gln
  65                  70                  75                  80
 Glu Gly Gly Gly Ser Gly Ser Tyr Glu Glu Gly Cys Gln Ser Leu Met
                  85                  90                  95    
 Glu Tyr Ala Trp Gly Arg Ala Ala Ala Ala Met Leu Phe Cys Gly Phe
             100                 105                 110        
 Ile Ile Leu Val Ile Cys Phe Ile Leu Ser Phe Phe Ala Leu Cys Gly
         115                 120                 125            
 Pro Gln Met Leu Val Phe Leu Arg Val Ile Gly Gly Leu Leu Ala Leu
     130                 135                 140                
 Ala Ala Val Phe Gln Ile Ile Ser Leu Val Ile Tyr Pro Val Lys Tyr
 145                 150                 155                 160
 Thr Gln Thr Phe Thr Leu His Ala Asn Arg Ala Val Thr Tyr Ile Tyr
                 165                 170                 175    
 Asn Trp Ala Tyr Gly Phe Gly Trp Ala Ala Thr Ile Ile Leu Ile Gly
             180                 185                 190        
 Cys Ala Phe Phe Phe Cys Cys Leu Pro Asn Tyr Glu Asp Asp Leu Leu
         195                 200                 205            
 Gly Asn Ala Lys Pro Arg Tyr Phe Tyr Thr Ser Ala
     210                 215                 220



      <210> 3119
      <211> 272
      <212> PRT
      <213> Homo sapiens

      <220>
      <221> misc_feature
      <222> (1)...(272)
      <223> Xaa = any amino acid or symbol as shown in the table 8 as set forth in Example 2


      <400> 3119
 Gly Gly Tyr Thr Lys Ser Gly Tyr Asp Ser Ala Cys Lys Asp Phe Val
   1               5                  10                  15    
 Pro His Asp Leu Glu Val Gln Ile Pro Gly Arg Val Phe Leu Val Thr
              20                  25                  30        
 Gly Gly Asn Ser Gly Ile Gly Lys Ala Thr Ala Leu Glu Ile Ala Lys
          35                  40                  45            
 Arg Gly Gly Thr Val His Leu Val Cys Arg Asp Gln Ala Pro Ala Glu
      50                  55                  60                
 Asp Ala Arg Gly Glu Ile Ile Arg Glu Ser Gly Asn Gln Asn Ile Phe
  65                  70                  75                  80
 Leu His Ile Val Asp Leu Ser Asp Pro Lys Lys Ile Trp Lys Phe Val
                  85                  90                  95    
 Glu Asn Phe Lys Gln Glu His Lys Leu His Val Leu Val Asn Asn Ala
             100                 105                 110        
 Gly Cys Met Val Asn Lys Arg Glu Ala His Lys Lys Met Asp Phe Glu
         115                 120                 125            
 Lys Asn Phe Gly Cys Gln Tyr Ser Gly Val Cys Thr Phe Leu Thr Thr
     130                 135                 140                
 Arg Pro Asp Pro Leu Cys Trp Arg Lys Asn Thr Asp Pro Arg Val Ile
 145                 150                 155                 160
 Thr Val Ser Ser Gly Gly Met Leu Val Gln Lys Leu Asn Asn Gln Xaa
                 165                 170                 175    
 Ser Pro Val Arg Lys Asn Thr Ile Trp Met Gly Thr Met Val Tyr Ala
             180                 185                 190        
 Gln Asn Lys Val Ser Glu Arg Gln Gln Val Val Leu Thr Glu Arg Trp
         195                 200                 205            
 Gly Pro Arg Ala Pro Gly Ile His Phe Ser Ser Met His Pro Gly Trp
     210                 215                 220                
 Ala Asp Thr Pro Gly Val Arg Gln Ala Met Pro Gly Phe His Val Gln
 225                 230                 235                 240
 Ala Ser Gly Tyr Arg Leu Arg Ser Glu Ala Gln Gly Ala Asp Thr Met
                 245                 250                 255    
 Leu Trp Leu Ala Leu Ser Ser Ala Arg Ser Arg Thr Ala Gln Arg Pro
             260                 265                 270        





      <210> 3120
      <211> 448
      <212> PRT
      <213> Homo sapiens


      <400> 3120
 Met Tyr Ile Ala Ser Gly Arg Pro Phe Cys Pro Ser Phe Gly Cys Pro
   1               5                  10                  15    
 Arg Ser Ser Pro Ser Pro Tyr Cys Ala Pro Val Leu Tyr Ala Gly Leu
              20                  25                  30        
 Leu Leu Leu Gly Leu Ala Ala Ser Ser Val Arg Ser Asn Leu Thr Ser
          35                  40                  45            
 Phe Gly Ala Asp Gln Val Met Asp Leu Gly Arg Asp Ala Thr Arg Arg
      50                  55                  60                
 Phe Phe Asn Trp Phe Tyr Trp Ser Ile Asn Leu Gly Ala Val Leu Ser
  65                  70                  75                  80
 Leu Leu Val Val Ala Phe Ile Gln Gln Asn Ile Ser Phe Leu Leu Gly
                  85                  90                  95    
 Tyr Ser Ile Pro Val Gly Cys Val Gly Leu Ala Phe Phe Ile Phe Leu
             100                 105                 110        
 Phe Ala Thr Pro Val Phe Ile Thr Lys Pro Pro Met Gly Ser Gln Val
         115                 120                 125            
 Ser Ser Met Leu Lys Leu Ala Leu Gln Asn Cys Cys Pro Gln Leu Trp
     130                 135                 140                
 Gln Arg His Ser Ala Arg Asp Arg Gln Cys Ala Arg Val Leu Ala Asp
 145                 150                 155                 160
 Glu Arg Ser Pro Gln Pro Gly Ala Ser Pro Gln Glu Asp Ile Ala Asn
                 165                 170                 175    
 Phe Gln Val Leu Val Lys Ile Leu Pro Val Met Val Thr Leu Val Pro
             180                 185                 190        
 Tyr Trp Met Val Tyr Phe Gln Met Gln Ser Thr Tyr Val Leu Gln Gly
         195                 200                 205            
 Leu His Leu His Ile Pro Asn Ile Phe Pro Ala Asn Pro Ala Asn Ile
     210                 215                 220                
 Ser Val Ala Leu Arg Ala Gln Gly Ser Ser Tyr Thr Ile Pro Glu Ala
 225                 230                 235                 240
 Trp Leu Leu Leu Ala Asn Val Val Val Val Leu Ile Leu Val Pro Leu
                 245                 250                 255    
 Lys Asp Arg Leu Ile Asp Pro Leu Leu Leu Arg Cys Lys Leu Leu Pro
             260                 265                 270        
 Ser Ala Leu Gln Lys Met Ala Leu Gly Met Phe Phe Gly Phe Thr Ser
         275                 280                 285            
 Val Ile Val Ala Gly Val Leu Glu Met Glu Arg Leu His Tyr Ile His
     290                 295                 300                
 His Asn Glu Thr Val Ser Gln Gln Ile Gly Gly Gly Leu Tyr Asn Ala
 305                 310                 315                 320
 Ala Pro Leu Ser Ile Trp Trp Gln Ile Pro Gln Tyr Leu Leu Ile Gly
                 325                 330                 335    
 Ile Ser Glu Ile Phe Ala Ser Ile Pro Gly Leu Glu Phe Ala Tyr Ser
             340                 345                 350        
 Glu Ala Pro Arg Ser Met Gln Gly Ala Ile Met Gly Ile Phe Phe Cys
         355                 360                 365            
 Leu Ser Gly Val Gly Ser Leu Leu Gly Ser Ser Leu Val Ala Leu Leu
     370                 375                 380                
 Ser Leu Pro Gly Gly Trp Leu His Cys Pro Lys Asp Phe Gly Asn Ile
 385                 390                 395                 400
 Asn Asn Cys Arg Met Asp Leu Tyr Phe Phe Leu Leu Ala Gly Ile Gln
                 405                 410                 415    
 Ala Val Thr Ala Leu Leu Phe Val Trp Ile Ala Gly Arg Tyr Glu Arg
             420                 425                 430        
 Ala Ser Gln Gly Pro Ala Ser His Ser Arg Phe Ser Arg Asp Arg Gly
         435                 440                 445            





      <210> 3121
      <211> 568
      <212> PRT
      <213> Homo sapiens


      <400> 3121
 Glu Arg Thr Leu Arg Gly Leu Arg Glu Val Ala Ala Pro Ser Asp Val
   1               5                  10                  15    
 Ala Asp Ala Ala Val Ser Arg Arg Gly Arg Cys Cys Cys Cys Leu His
              20                  25                  30        
 Cys Thr Gln Thr Gln Val Ala Gln Asp Cys Pro Ser Ser Ser Ser Ser
          35                  40                  45            
 Val Gln Arg Cys Glu Leu Ser Leu Phe Gln Ser Leu His Thr Met Thr
      50                  55                  60                
 Ser Lys Lys Leu Val Asn Ser Val Ala Gly Cys Ala Asp Asp Ala Leu
  65                  70                  75                  80
 Ala Gly Leu Val Ala Cys Asn Pro Asn Leu Gln Leu Leu Gln Gly His
                  85                  90                  95    
 Arg Val Ala Leu Arg Ser Asp Leu Asp Ser Leu Lys Gly Arg Val Ala
             100                 105                 110        
 Leu Leu Ser Gly Gly Gly Ser Gly His Glu Pro Ala His Ala Gly Phe
         115                 120                 125            
 Ile Gly Lys Gly Met Leu Thr Gly Val Ile Ala Gly Ala Val Phe Thr
     130                 135                 140                
 Ser Pro Ala Val Gly Ser Ile Leu Ala Ala Ile Arg Ala Val Ala Gln
 145                 150                 155                 160
 Ala Gly Thr Val Gly Thr Leu Leu Ile Val Lys Asn Tyr Thr Gly Asp
                 165                 170                 175    
 Arg Leu Asn Phe Gly Leu Ala Arg Glu Gln Ala Arg Ala Glu Gly Ile
             180                 185                 190        
 Pro Val Glu Met Val Val Ile Gly Asp Asp Ser Ala Phe Thr Val Leu
         195                 200                 205            
 Lys Lys Ala Gly Arg Arg Gly Leu Cys Gly Thr Val Leu Ile His Lys
     210                 215                 220                
 Val Ala Gly Ala Leu Ala Glu Ala Gly Val Gly Leu Glu Glu Ile Ala
 225                 230                 235                 240
 Lys Gln Val Asn Val Val Thr Lys Ala Met Gly Thr Leu Gly Val Ser
                 245                 250                 255    
 Leu Ser Ser Cys Ser Val Pro Gly Ser Lys Pro Thr Phe Glu Leu Ser
             260                 265                 270        
 Ala Asp Glu Val Glu Leu Gly Leu Gly Ile His Gly Glu Ala Gly Val
         275                 280                 285            
 Arg Arg Ile Lys Met Ala Thr Ala Asp Glu Ile Val Lys Leu Met Leu
     290                 295                 300                
 Asp His Met Thr Asn Thr Thr Asn Ala Ser His Val Pro Val Gln Pro
 305                 310                 315                 320
 Gly Ser Ser Val Val Met Met Val Asn Asn Leu Gly Gly Leu Ser Phe
                 325                 330                 335    
 Leu Glu Leu Gly Ile Ile Ala Asp Ala Thr Val Arg Ser Leu Glu Gly
             340                 345                 350        
 Arg Gly Val Lys Ile Ala Arg Ala Leu Val Gly Thr Phe Met Ser Ala
         355                 360                 365            
 Leu Glu Met Pro Gly Ile Ser Leu Thr Leu Leu Leu Val Asp Glu Pro
     370                 375                 380                
 Leu Leu Lys Leu Ile Asp Ala Glu Thr Thr Ala Ala Ala Trp Pro Asn
 385                 390                 395                 400
 Val Ala Ala Val Ser Ile Thr Gly Arg Lys Arg Ser Arg Val Ala Pro
                 405                 410                 415    
 Ala Glu Pro Gln Glu Ala Pro Asp Ser Thr Ala Ala Gly Gly Ser Ala
             420                 425                 430        
 Ser Lys Arg Met Ala Leu Val Leu Glu Arg Val Cys Ser Thr Leu Leu
         435                 440                 445            
 Gly Leu Glu Glu His Leu Asn Ala Leu Asp Arg Ala Ala Gly Asp Gly
     450                 455                 460                
 Asp Cys Gly Thr Thr His Ser Arg Ala Ala Arg Ala Ile Gln Glu Trp
 465                 470                 475                 480
 Leu Lys Glu Gly Pro Pro Pro Ala Ser Pro Ala Gln Leu Leu Ser Lys
                 485                 490                 495    
 Leu Ser Val Leu Leu Leu Glu Lys Met Gly Gly Ser Ser Gly Ala Leu
             500                 505                 510        
 Tyr Gly Leu Phe Leu Thr Ala Ala Ala Gln Pro Leu Lys Ala Lys Thr
         515                 520                 525            
 Ser Leu Pro Ala Trp Ser Ala Ala Met Asp Ala Gly Leu Glu Ala Met
     530                 535                 540                
 Gln Lys Tyr Gly Lys Ala Ala Pro Gly Asp Arg Thr Met Leu Asp Ser
 545                 550                 555                 560
 Leu Trp Ala Ala Gly Gln Glu Leu
                 565            



      <210> 3122
      <211> 260
      <212> PRT
      <213> Homo sapiens


      <400> 3122
 Asn Glu Gly Leu Glu Val Phe Lys Glu Gln Glu Leu Gln Pro Glu Asp
   1               5                  10                  15    
 Lys Gly Ala Val Pro Glu Asp Ala Ser Thr Glu Arg Ser Ala Met Ala
              20                  25                  30        
 Ser Leu Gly Leu Gln Leu Val Gly Tyr Ile Leu Gly Leu Leu Gly Leu
          35                  40                  45            
 Leu Gly Thr Leu Val Ala Met Leu Leu Pro Ser Trp Lys Thr Ser Ser
      50                  55                  60                
 Tyr Val Gly Ala Ser Ile Val Thr Ala Val Gly Phe Ser Lys Gly Leu
  65                  70                  75                  80
 Trp Met Glu Cys Ala Thr His Ser Thr Gly Ile Thr Gln Cys Asp Ile
                  85                  90                  95    
 Tyr Ser Thr Leu Leu Gly Leu Pro Ala Asp Ile Gln Ala Ala Gln Ala
             100                 105                 110        
 Met Met Val Thr Ser Ser Ala Ile Ser Ser Leu Ala Cys Ile Ile Ser
         115                 120                 125            
 Val Val Gly Met Arg Cys Thr Val Phe Cys Gln Glu Ser Arg Ala Lys
     130                 135                 140                
 Asp Arg Val Ala Val Ala Gly Gly Val Phe Phe Ile Leu Gly Gly Leu
 145                 150                 155                 160
 Leu Gly Phe Ile Pro Val Ala Trp Asn Leu His Gly Ile Leu Arg Asp
                 165                 170                 175    
 Phe Tyr Ser Pro Leu Val Pro Asp Ser Met Lys Phe Glu Ile Gly Glu
             180                 185                 190        
 Ala Leu Tyr Leu Gly Ile Ile Ser Ser Leu Phe Ser Leu Ile Ala Gly
         195                 200                 205            
 Ile Ile Leu Cys Phe Ser Cys Ser Cys Gln Arg Asn Arg Ser Asn Tyr
     210                 215                 220                
 Tyr Asp Ala Tyr Gln Ala Gln Pro Leu Ala Thr Arg Ser Ser Pro Arg
 225                 230                 235                 240
 Pro Gly Gln Pro Pro Lys Val Lys Ser Glu Phe Asn Ser Tyr Ser Leu
                 245                 250                 255    
 Thr Gly Tyr Val
             260



      <210> 3123
      <211> 356
      <212> PRT
      <213> Homo sapiens


      <400> 3123
 Ser Cys Arg Leu Ala Ala Gly Arg Leu Ala Gln Trp Leu Leu Arg Ala
   1               5                  10                  15    
 Ser Arg Ser Gly Met Leu Arg Ala Gly Trp Leu Arg Gly Ala Ala Ala
              20                  25                  30        
 Leu Ala Leu Leu Leu Ala Ala Arg Val Val Ala Ala Phe Glu Pro Ile
          35                  40                  45            
 Thr Val Gly Leu Ala Ile Gly Ala Ala Ser Ala Ile Thr Gly Tyr Leu
      50                  55                  60                
 Ser Tyr Asn Asp Ile Tyr Cys Arg Phe Ala Glu Cys Cys Arg Glu Glu
  65                  70                  75                  80
 Arg Pro Leu Asn Ala Ser Ala Leu Lys Leu Asp Leu Glu Glu Lys Leu
                  85                  90                  95    
 Phe Gly Gln His Leu Ala Thr Glu Val Ile Phe Lys Ala Leu Thr Gly
             100                 105                 110        
 Phe Arg Asn Asn Lys Asn Pro Lys Lys Pro Leu Thr Leu Ser Leu His
         115                 120                 125            
 Gly Trp Ala Gly Thr Gly Lys Asn Phe Val Ser Gln Met Gly Ala Glu
     130                 135                 140                
 Asn Leu His Pro Lys Gly Leu Lys Ser Asn Phe Val His Leu Phe Val
 145                 150                 155                 160
 Ser Thr Leu His Phe Pro His Glu Gln Lys Ile Lys Leu Tyr Gln Asp
                 165                 170                 175    
 Gln Leu Gln Lys Trp Ile Arg Gly Asn Val Ser Ala Cys Ala Asn Ser
             180                 185                 190        
 Val Phe Ile Phe Asp Glu Met Asp Lys Leu His Pro Gly Ile Ile Glu
         195                 200                 205            
 Ala Ile Lys Pro Phe Leu Asp Tyr Tyr Glu His Val Glu Arg Val Ser
     210                 215                 220                
 Tyr Arg Lys Ala Ile Phe Ile Phe Leu Ser Asn Ala Gly Gly Asp Leu
 225                 230                 235                 240
 Ile Thr Lys Thr Ala Leu Asp Phe Trp Arg Ala Gly Arg Lys Arg Glu
                 245                 250                 255    
 Asp Ile Gln Leu Lys Asp Leu Glu Pro Val Leu Ser Val Gly Val Phe
             260                 265                 270        
 Asn Asn Lys His Ser Gly Leu Trp His Ser Gly Leu Ile Asp Lys Asn
         275                 280                 285            
 Leu Ile Asp Tyr Phe Ile Pro Phe Leu Pro Leu Glu Tyr Arg His Val
     290                 295                 300                
 Lys Met Cys Val Arg Ala Glu Met Arg Ala Arg Gly Ser Ala Ile Asp
 305                 310                 315                 320
 Glu Asp Ile Val Thr Arg Val Ala Glu Glu Met Thr Phe Phe Pro Arg
                 325                 330                 335    
 Asp Glu Lys Ile Tyr Ser Asp Lys Gly Cys Lys Thr Val Gln Ser Arg
             340                 345                 350        
 Leu Asp Phe His
         355    



      <210> 3124
      <211> 249
      <212> PRT
      <213> Homo sapiens


      <400> 3124
 Asp Asp Ser Gly Leu His Phe Phe Leu Thr Ala Pro Ser Val Leu Val
   1               5                  10                  15    
 Leu Cys Met Gly Leu Tyr Leu Leu Leu Ser Arg Leu Glu Tyr Ala Arg
              20                  25                  30        
 Tyr Tyr Met Arg Pro Val Leu Ala Ala His Val Phe Ser Gly Glu Glu
          35                  40                  45            
 Glu Leu Pro Gln Asp Ser Leu Ser Ala Pro Ser Val Ala Ser Arg Phe
      50                  55                  60                
 Ile Asp Ser His Thr Pro Pro Leu Arg Pro Ile Leu Lys Lys Thr Ala
  65                  70                  75                  80
 Ser Leu Gly Phe Cys Val Thr Tyr Val Phe Phe Ile Thr Ser Leu Ile
                  85                  90                  95    
 Tyr Pro Ala Val Cys Thr Asn Ile Glu Ser Leu Asn Lys Gly Ser Gly
             100                 105                 110        
 Ser Leu Trp Thr Thr Lys Phe Phe Ile Pro Leu Thr Thr Phe Leu Leu
         115                 120                 125            
 Tyr Asn Phe Ala Asp Leu Cys Gly Arg Gln Leu Thr Ala Trp Ile Gln
     130                 135                 140                
 Val Pro Gly Pro Asn Ser Lys Ala Leu Pro Gly Phe Val Leu Leu Arg
 145                 150                 155                 160
 Thr Cys Leu Ile Pro Leu Phe Val Leu Cys Asn Tyr Gln Pro Arg Val
                 165                 170                 175    
 His Leu Lys Thr Val Val Phe Gln Ser Asp Val Tyr Pro Ala Leu Leu
             180                 185                 190        
 Ser Ser Leu Leu Gly Leu Ser Asn Gly Tyr Leu Ser Thr Leu Ala Leu
         195                 200                 205            
 Leu Tyr Gly Pro Lys Ile Val Pro Arg Glu Leu Ala Glu Ala Thr Gly
     210                 215                 220                
 Val Val Met Ser Phe Tyr Val Cys Leu Gly Leu Thr Leu Gly Ser Ala
 225                 230                 235                 240
 Cys Ser Thr Leu Leu Val His Leu Ile
                 245                



      <210> 3125
      <211> 313
      <212> PRT
      <213> Homo sapiens


      <400> 3125
 Arg Ile Ile Ser Thr Ile Thr Tyr Gln Phe Ser Ala Ala Leu Gly Gln
   1               5                  10                  15    
 Glu Val Phe Tyr Ile Thr Phe Leu Pro Phe Thr His Trp Asn Ile Asp
              20                  25                  30        
 Pro Tyr Leu Ser Arg Arg Leu Ile Ile Ile Trp Val Leu Val Met Tyr
          35                  40                  45            
 Ile Gly Gln Val Ala Lys Asp Val Leu Lys Trp Pro Arg Pro Ser Ser
      50                  55                  60                
 Pro Pro Val Val Lys Leu Glu Lys Arg Leu Ile Ala Glu Tyr Gly Met
  65                  70                  75                  80
 Pro Ser Thr His Ala Met Ala Ala Thr Ala Ile Ala Phe Thr Leu Leu
                  85                  90                  95    
 Ile Ser Thr Met Asp Arg Tyr Gln Tyr Pro Phe Val Leu Gly Leu Val
             100                 105                 110        
 Met Ala Val Val Phe Ser Thr Leu Val Cys Leu Ser Arg Leu Tyr Thr
         115                 120                 125            
 Gly Met His Thr Val Leu Asp Val Leu Gly Gly Val Leu Ile Thr Ala
     130                 135                 140                
 Leu Leu Ile Val Leu Thr Tyr Pro Ala Trp Thr Phe Ile Asp Cys Leu
 145                 150                 155                 160
 Asp Ser Ala Ser Pro Leu Phe Pro Val Cys Val Ile Val Val Pro Phe
                 165                 170                 175    
 Phe Leu Cys Tyr Asn Tyr Pro Val Ser Asp Tyr Tyr Ser Pro Thr Arg
             180                 185                 190        
 Ala Asp Thr Thr Thr Ile Leu Ala Ala Gly Ala Gly Val Thr Ile Gly
         195                 200                 205            
 Phe Trp Ile Asn His Phe Phe Gln Leu Val Ser Lys Pro Ala Glu Ser
     210                 215                 220                
 Leu Pro Val Ile Gln Asn Ile Pro Pro Leu Thr Thr Tyr Met Leu Val
 225                 230                 235                 240
 Leu Gly Leu Thr Lys Phe Ala Val Gly Ile Val Leu Ile Leu Leu Val
                 245                 250                 255    
 Arg Gln Leu Val Gln Asn Leu Ser Leu Gln Val Leu Tyr Ser Trp Phe
             260                 265                 270        
 Lys Val Val Thr Arg Asn Lys Glu Ala Arg Arg Arg Leu Glu Ile Glu
         275                 280                 285            
 Val Pro Tyr Lys Phe Val Thr Tyr Thr Ser Val Gly Ile Gly Thr Lys
     290                 295                 300                
 Val Val Ala Gln Met Pro Thr Asp Val
 305                 310            



      <210> 3126
      <211> 315
      <212> PRT
      <213> Homo sapiens


      <400> 3126
 Trp Lys Ala Met Glu Ser Ala Leu Pro Ala Ala Gly Phe Leu Tyr Trp
   1               5                  10                  15    
 Val Gly Ala Gly Thr Val Ala Tyr Leu Ala Leu Arg Ile Ser Tyr Ser
              20                  25                  30        
 Leu Phe Thr Ala Leu Arg Val Trp Gly Val Gly Asn Glu Ala Gly Val
          35                  40                  45            
 Gly Pro Gly Leu Gly Glu Trp Ala Val Val Thr Gly Ser Thr Asp Gly
      50                  55                  60                
 Ile Gly Lys Ser Tyr Ala Glu Glu Leu Ala Lys His Gly Met Lys Val
  65                  70                  75                  80
 Val Leu Ile Ser Arg Ser Lys Asp Lys Leu Asp Gln Val Ser Ser Glu
                  85                  90                  95    
 Ile Lys Glu Lys Phe Lys Val Glu Thr Arg Thr Ile Ala Val Asp Phe
             100                 105                 110        
 Ala Ser Glu Asp Ile Tyr Asp Lys Ile Lys Thr Gly Leu Ala Gly Leu
         115                 120                 125            
 Glu Ile Gly Ile Leu Val Asn Asn Val Gly Met Ser Tyr Glu Tyr Pro
     130                 135                 140                
 Glu Tyr Phe Leu Asp Val Pro Asp Leu Asp Asn Val Ile Lys Lys Met
 145                 150                 155                 160
 Ile Asn Ile Asn Ile Leu Ser Val Cys Lys Met Thr Gln Leu Val Leu
                 165                 170                 175    
 Pro Gly Met Val Glu Arg Ser Lys Gly Ala Ile Leu Asn Ile Ser Ser
             180                 185                 190        
 Gly Ser Gly Met Leu Pro Val Pro Leu Leu Thr Ile Tyr Ser Ala Thr
         195                 200                 205            
 Lys Thr Phe Val Asp Phe Phe Ser Gln Cys Leu His Glu Glu Tyr Arg
     210                 215                 220                
 Ser Lys Gly Val Phe Val Gln Ser Val Leu Pro Tyr Phe Val Ala Thr
 225                 230                 235                 240
 Lys Leu Ala Lys Ile Arg Lys Pro Thr Leu Asp Lys Pro Ser Pro Glu
                 245                 250                 255    
 Thr Phe Val Lys Ser Ala Ile Lys Thr Val Gly Leu Gln Ser Arg Thr
             260                 265                 270        
 Asn Gly Tyr Leu Ile His Ala Leu Met Gly Leu Ile Ile Ser Asn Leu
         275                 280                 285            
 Pro Ser Trp Ile Tyr Leu Lys Ile Val Met Asn Met Asn Lys Ser Thr
     290                 295                 300                
 Arg Ala His Tyr Leu Lys Lys Thr Lys Lys Asn
 305                 310                 315



      <210> 3127
      <211> 565
      <212> PRT
      <213> Homo sapiens


      <400> 3127
 Leu Arg Ala Ala Gly Gly Gly Arg Thr Met Pro Ser Phe Asp Glu Ala
   1               5                  10                  15    
 Leu Gln Arg Val Gly Glu Phe Gly Arg Phe Gln Arg Arg Val Phe Leu
              20                  25                  30        
 Leu Leu Cys Leu Thr Gly Val Thr Phe Ala Phe Leu Phe Val Gly Val
          35                  40                  45            
 Val Phe Leu Gly Thr Gln Pro Asp His Tyr Trp Cys Arg Gly Pro Ser
      50                  55                  60                
 Ala Ala Ala Leu Ala Glu Arg Cys Gly Trp Ser Pro Glu Glu Glu Trp
  65                  70                  75                  80
 Asn Arg Thr Ala Pro Ala Ser Arg Gly Pro Glu Pro Pro Glu Arg Arg
                  85                  90                  95    
 Gly Arg Cys Gln Arg Tyr Leu Leu Glu Ala Ala Asn Asp Ser Ala Ser
             100                 105                 110        
 Ala Thr Ser Ala Leu Ser Cys Ala Asp Pro Leu Ala Ala Phe Pro Asn
         115                 120                 125            
 Arg Ser Ala Pro Leu Val Pro Cys Arg Gly Gly Trp Arg Tyr Ala Gln
     130                 135                 140                
 Ala His Ser Thr Ile Val Ser Glu Phe Asp Leu Val Cys Val Asn Ala
 145                 150                 155                 160
 Trp Met Leu Asp Leu Thr Gln Ala Ile Leu Asn Leu Gly Phe Leu Thr
                 165                 170                 175    
 Gly Ala Phe Thr Leu Gly Tyr Ala Ala Asp Arg Tyr Gly Arg Ile Val
             180                 185                 190        
 Ile Tyr Leu Leu Ser Cys Leu Gly Val Gly Val Thr Gly Val Val Val
         195                 200                 205            
 Ala Phe Ala Pro Asn Phe Pro Val Phe Val Ile Phe Arg Phe Leu Gln
     210                 215                 220                
 Gly Val Phe Gly Lys Gly Thr Trp Met Thr Cys Tyr Val Ile Val Thr
 225                 230                 235                 240
 Glu Ile Val Gly Ser Lys Gln Arg Arg Ile Val Gly Ile Val Ile Gln
                 245                 250                 255    
 Met Phe Phe Thr Leu Gly Ile Ile Ile Leu Pro Gly Ile Ala Tyr Phe
             260                 265                 270        
 Ile Pro Asn Trp Gln Gly Ile Gln Leu Ala Ile Thr Leu Pro Ser Phe
         275                 280                 285            
 Leu Phe Leu Leu Tyr Tyr Trp Val Val Pro Glu Ser Pro Arg Trp Leu
     290                 295                 300                
 Ile Thr Arg Lys Lys Gly Asp Lys Ala Leu Gln Ile Leu Arg Arg Ile
 305                 310                 315                 320
 Ala Lys Cys Asn Gly Lys Tyr Leu Ser Ser Asn Tyr Ser Glu Ile Thr
                 325                 330                 335    
 Val Thr Asp Glu Glu Val Ser Asn Pro Ser Phe Leu Asp Leu Val Arg
             340                 345                 350        
 Thr Pro Gln Met Arg Lys Cys Thr Leu Ile Leu Met Phe Ala Trp Phe
         355                 360                 365            
 Thr Ser Ala Val Val Tyr Gln Gly Leu Val Met Arg Leu Gly Ile Ile
     370                 375                 380                
 Gly Gly Asn Leu Tyr Ile Asp Phe Phe Ile Ser Gly Val Val Glu Leu
 385                 390                 395                 400
 Pro Gly Ala Leu Leu Ile Leu Leu Thr Ile Glu Arg Leu Gly Arg Arg
                 405                 410                 415    
 Leu Pro Phe Ala Ala Ser Asn Ile Val Ala Gly Val Ala Cys Leu Val
             420                 425                 430        
 Thr Ala Phe Leu Pro Glu Gly Ile Ala Trp Leu Arg Thr Thr Val Ala
         435                 440                 445            
 Thr Leu Gly Arg Leu Gly Ile Thr Met Ala Phe Glu Ile Val Tyr Leu
     450                 455                 460                
 Val Asn Ser Glu Leu Tyr Pro Thr Thr Leu Arg Asn Phe Gly Val Ser
 465                 470                 475                 480
 Leu Cys Ser Gly Leu Cys Asp Phe Gly Gly Ile Ile Ala Pro Phe Leu
                 485                 490                 495    
 Leu Phe Arg Leu Ala Ala Val Trp Leu Glu Leu Pro Leu Ile Ile Phe
             500                 505                 510        
 Gly Ile Leu Ala Ser Ile Cys Gly Gly Leu Val Met Leu Leu Pro Glu
         515                 520                 525            
 Thr Lys Gly Ile Ala Leu Pro Glu Thr Val Asp Asp Val Glu Lys Leu
     530                 535                 540                
 Gly Ser Pro His Ser Cys Lys Cys Gly Arg Asn Lys Lys Thr Pro Val
 545                 550                 555                 560
 Ser Arg Ser His Leu
                 565



      <210> 3128
      <211> 254
      <212> PRT
      <213> Homo sapiens


      <400> 3128
 Arg Thr Ser Leu Val Tyr Asp Tyr Pro Leu Arg Arg Arg Trp Leu Arg
   1               5                  10                  15    
 Arg Gln Arg Gly Gly Gly Gly Phe Cys Phe Gly Cys Gly Gly Arg Ser
              20                  25                  30        
 Pro Gly Pro Gly Phe Gly Leu Ser Pro Thr Val Val Thr Leu Ala Glu
          35                  40                  45            
 Leu Leu Val Leu Leu Ala Ala Leu Leu Ala Thr Val Ser Gly Tyr Phe
      50                  55                  60                
 Val Ser Ile Asp Ala His Ala Glu Glu Cys Phe Phe Glu Arg Val Thr
  65                  70                  75                  80
 Ser Gly Thr Lys Met Gly Leu Ile Phe Glu Val Ala Glu Gly Gly Phe
                  85                  90                  95    
 Leu Asp Ile Asp Val Glu Ile Thr Gly Pro Asp Asn Ile Gly Ile Leu
             100                 105                 110        
 Pro Thr Arg Leu Tyr Asn Leu Ser Gly Lys Tyr Thr Phe Ala Ala His
         115                 120                 125            
 Met Asp Gly Thr Tyr Lys Phe Cys Phe Ser Asn Arg Met Ser Thr Met
     130                 135                 140                
 Thr Pro Lys Ile Val Met Phe Thr Ile Asp Ile Gly Glu Ala Pro Lys
 145                 150                 155                 160
 Gly Gln Asp Met Glu Thr Glu Ala His Gln Asn Lys Leu Glu Glu Met
                 165                 170                 175    
 Ile Asn Glu Leu Ala Val Ala Met Thr Ala Val Lys His Glu Gln Glu
             180                 185                 190        
 Tyr Met Glu Val Arg Glu Arg Ile His Arg Ala Ile Gln Arg Thr Thr
         195                 200                 205            
 Gln Asn Ser Arg Val Val Leu Trp Ser Phe Phe Glu Ala Leu Val Ala
     210                 215                 220                
 Cys Cys His Asp Ile Trp Gly Gln Ile Tyr Tyr Leu Glu Gly Asp Phe
 225                 230                 235                 240
 Phe Glu Val Arg Arg Ser Cys Phe Lys Lys Pro Leu Pro Gly
                 245                 250                



      <210> 3129
      <211> 620
      <212> PRT
      <213> Homo sapiens


      <400> 3129
 Asp Ala Phe Lys Ala Val Cys Arg Gly Lys Phe Ile Ala Leu Asn Ala
   1               5                  10                  15    
 His Lys Arg Lys Gln Glu Arg Ser Lys Ile Asp Thr Leu Thr Ser Gln
              20                  25                  30        
 Leu Lys Glu Leu Glu Lys Gln Glu Gln Thr His Ser Lys Ala Ser Arg
          35                  40                  45            
 Arg Gln Glu Ile Thr Lys Ile Arg Ala Glu Leu Lys Glu Ile Glu Thr
      50                  55                  60                
 Gln Lys Thr Leu Gln Lys Ile Asn Glu Ser Arg Ser Trp Phe Phe Glu
  65                  70                  75                  80
 Arg Ile Asn Lys Ile Asp Arg Pro Leu Ala Arg Leu Ile Lys Lys Lys
                  85                  90                  95    
 Arg Glu Lys Asn Gln Ile Asp Thr Ile Lys Asn Asp Lys Gly Asp Ile
             100                 105                 110        
 Thr Thr Asp Pro Thr Glu Ile Gln Thr Thr Ile Arg Glu Tyr Tyr Lys
         115                 120                 125            
 His Leu Tyr Ala Asn Lys Leu Glu Asn Leu Glu Glu Met Asp Thr Phe
     130                 135                 140                
 Leu Asp Thr Tyr Thr Leu Pro Arg Leu Asn Gln Glu Glu Val Glu Ser
 145                 150                 155                 160
 Leu Asn Arg Pro Ile Thr Gly Ala Glu Ile Val Ala Ile Ile Asn Ser
                 165                 170                 175    
 Leu Ser Thr Lys Lys Ser Pro Gly Pro Asp Gly Phe Thr Ala Glu Phe
             180                 185                 190        
 Tyr Gln Arg Tyr Lys Glu Glu Leu Val Pro Phe Phe Leu Lys Leu Phe
         195                 200                 205            
 Gln Ser Ile Glu Lys Glu Gly Ile Leu Pro Asn Ser Phe Tyr Glu Ala
     210                 215                 220                
 Ser Ile Ile Leu Ile Pro Lys Pro Gly Arg Asp Thr Thr Lys Lys Glu
 225                 230                 235                 240
 Asn Phe Arg Pro Ile Ser Leu Met Asn Ile Asp Ala Lys Ile Leu Asn
                 245                 250                 255    
 Lys Ile Leu Ala Asn Gln Ile Gln Gln His Ile Lys Lys Leu Ile His
             260                 265                 270        
 His Asp Gln Val Gly Phe Ile Pro Gly Met Gln Gly Trp Phe Asn Ile
         275                 280                 285            
 Arg Lys Ser Ile Asn Val Ile Gln His Ile Asn Arg Ala Lys Asp Lys
     290                 295                 300                
 Asn His Met Ile Val Ser Ile Asp Ala Glu Lys Ala Phe Asp Lys Ile
 305                 310                 315                 320
 Gln Gln Pro Phe Met Leu Lys Thr Ile Asn Lys Ile Gly Ile Asp Gly
                 325                 330                 335    
 Met Tyr Phe Lys Ile Ile Arg Ala Ile Tyr Asp Lys Thr Thr Ala Asn
             340                 345                 350        
 Ile Ile Leu Asn Gly Gln Lys Leu Glu Ala Phe Pro Leu Lys Thr Gly
         355                 360                 365            
 Thr Arg Gln Gly Cys Pro Leu Ser Pro Leu Leu Phe Asn Ile Val Leu
     370                 375                 380                
 Glu Phe Leu Ala Arg Ala Ile Arg Gln Glu Lys Glu Ile Lys Gly Ile
 385                 390                 395                 400
 Gln Leu Gly Lys Glu Glu Val Lys Leu Ser Leu Phe Ala Asp Asp Met
                 405                 410                 415    
 Ile Val Asp Leu Glu Asn Pro Ile Val Ser Ala Gln Asn Leu Leu Lys
             420                 425                 430        
 Leu Ile Ser Asn Phe Ser Lys Leu Ser Gly Tyr Lys Ile Asn Val Gln
         435                 440                 445            
 Lys Ser Gln Ala Phe Leu Tyr Thr Asn Asn Arg Gln Thr Glu Ser Gln
     450                 455                 460                
 Ile Met Ser Glu Leu Pro Phe Thr Ile Ala Ser Lys Arg Ile Lys Tyr
 465                 470                 475                 480
 Leu Gly Ile Gln Leu Thr Arg Asp Val Lys Asp Leu Phe Lys Glu Asn
                 485                 490                 495    
 Tyr Lys Pro Leu Leu Lys Glu Ile Lys Glu Asp Thr Lys Lys Trp Lys
             500                 505                 510        
 Asn Thr Pro Cys Ser Trp Val Gly Arg Ile Asn Ile Val Lys Met Ala
         515                 520                 525            
 Ile Leu Pro Lys Val Ile Tyr Arg Phe Asn Ala Ile Pro Ile Lys Leu
     530                 535                 540                
 Pro Met Thr Phe Phe Thr Glu Leu Glu Lys Thr Thr Leu Lys Phe Ile
 545                 550                 555                 560
 Trp Asn Gln Lys Arg Ala Arg Ile Ala Lys Ser Ile Leu Ser Gln Lys
                 565                 570                 575    
 Asn Lys Ala Gly Gly Ile Thr Leu Pro Asp Phe Lys Leu Tyr Tyr Lys
             580                 585                 590        
 Ala Thr Val Thr Lys Thr Ala Trp Tyr Trp Tyr Gln Asn Arg Asp Ile
         595                 600                 605            
 Asp Gln Trp Asn Arg Thr Glu Pro Ser Glu Ile Thr
     610                 615                 620



      <210> 3130
      <211> 83
      <212> PRT
      <213> Homo sapiens


      <400> 3130
 Leu Leu Ile Tyr Leu Ala Ile Phe Ala Pro Val Ala Met Ser Ala Leu
   1               5                  10                  15    
 Ala Gly Val Lys Ser Val Gln Gln Val Arg Ile Arg Ala Ala Gln Ser
              20                  25                  30        
 Leu Gly Ala Ser Arg Ala Gln Val Leu Trp Phe Val Ile Leu Pro Gly
          35                  40                  45            
 Ala Leu Pro Glu Ile Leu Thr Gly Leu Arg Ile Gly Leu Gly Val Gly
      50                  55                  60                
 Trp Ser Thr Leu Val Ala Ala Glu Leu Ile Ala Ala Thr Arg Gly Leu
  65                  70                  75                  80
 Gly Phe Met
            



      <210> 3131
      <211> 1325
      <212> PRT
      <213> Homo sapiens


      <400> 3131
 Met Gly Cys Tyr Asp Asp Ile Glu Gln Ala Asp Ala Phe Val Leu Trp
   1               5                  10                  15    
 Gly Ala Asn Met Ala Glu Met His Pro Ile Leu Trp Ser Arg Ile Thr
              20                  25                  30        
 Asn Arg Arg Leu Ser Asn Gln Asn Val Thr Val Ala Val Leu Ser Thr
          35                  40                  45            
 Tyr Gln His Arg Ser Phe Glu Leu Ala Asp Asn Gly Ile Ile Phe Thr
      50                  55                  60                
 Pro Gln Ser Asp Leu Val Ile Leu Asn Tyr Ile Ala Asn Tyr Ile Ile
  65                  70                  75                  80
 Gln Asn Asn Ala Ile Asn Gln Asp Phe Phe Ser Lys His Val Asn Leu
                  85                  90                  95    
 Arg Lys Gly Ala Thr Asp Ile Gly Tyr Gly Leu Arg Pro Thr His Pro
             100                 105                 110        
 Leu Glu Lys Ala Ala Lys Asn Pro Gly Ser Asp Ala Ser Glu Pro Met
         115                 120                 125            
 Ser Phe Glu Asp Tyr Lys Ala Phe Val Ala Glu Tyr Thr Leu Glu Lys
     130                 135                 140                
 Thr Ala Glu Met Thr Gly Val Pro Lys Asp Gln Leu Glu Gln Leu Ala
 145                 150                 155                 160
 Gln Leu Tyr Ala Asp Pro Asn Lys Lys Val Ile Ser Tyr Trp Thr Met
                 165                 170                 175    
 Gly Phe Asn Gln His Thr Arg Gly Val Trp Ala Asn Asn Leu Val Tyr
             180                 185                 190        
 Asn Leu His Leu Leu Thr Gly Lys Ile Ser Gln Pro Gly Cys Asp Gly
         195                 200                 205            
 Ala Tyr Val Lys Val Lys Pro Gly Ala Gln Thr Ala Ile Val Asn Gly
     210                 215                 220                
 Gln Pro Leu Ala Leu Gln Val Pro Val Val Met Lys Asp Asn Lys Ala
 225                 230                 235                 240
 Trp Val Ser Asp Thr Phe Ile Asn Asp Val Phe Gln Ser Gly Leu Asp
                 245                 250                 255    
 Gln Thr Phe Gln Val Glu Lys Arg Pro His Pro Leu Asn Ala Leu Thr
             260                 265                 270        
 Ala Asp Glu Ile Lys Gln Ala Val Glu Ile Val Lys Ala Ser Ala Asp
         275                 280                 285            
 Phe Lys Pro Asn Thr Arg Phe Thr Glu Ile Ser Leu Leu Pro Pro Asp
     290                 295                 300                
 Lys Glu Ala Val Trp Ala Phe Ala Leu Glu Asn Lys Pro Val Asp Gln
 305                 310                 315                 320
 Pro Arg Lys Ala Asp Val Ile Met Leu Asp Gly Lys His Ile Ile Glu
                 325                 330                 335    
 Ala Val Val Asp Leu Gln Asn Asn Lys Leu Leu Ser Trp Gln Pro Ile
             340                 345                 350        
 Lys Asp Ala His Gly Met Val Leu Leu Asp Asp Phe Ala Ser Val Gln
         355                 360                 365            
 Asn Ile Ile Asn Asn Ser Glu Glu Phe Ala Ala Ala Val Lys Lys Arg
     370                 375                 380                
 Gly Ile Thr Asp Ala Lys Lys Val Ile Thr Thr Pro Leu Thr Val Gly
 385                 390                 395                 400
 Tyr Phe Asp Gly Gln Asp Gly Leu Lys Gln Asp Ala Arg Leu Leu Lys
                 405                 410                 415    
 Val Ile Ser Tyr Leu Asp Val Gly Asp Gly Asn Tyr Trp Ala His Pro
             420                 425                 430        
 Ile Glu Asn Leu Val Ala Val Val Asp Leu Glu Gln Lys Lys Ile Val
         435                 440                 445            
 Thr Arg Ser Ala Thr Leu Leu Pro Ser Ser Ser Val Thr Pro Cys Ile
     450                 455                 460                
 Thr Asp Lys Asp Trp Gln Thr Thr Ser Phe Gly Arg Leu Ser Ser Cys
 465                 470                 475                 480
 Ile Ser Arg Asn Ala Phe Thr Val Ser Glu Leu Ala Leu Met Ala Asp
                 485                 490                 495    
 Lys Ser Ala Ala Ser Gly Asn Thr Ala Glu Gly Arg Thr Ser Ala Met
             500                 505                 510        
 Ala Glu Asn Arg Ile Val Leu Ser Ile Arg Ser Ile Leu Ala Ser Lys
         515                 520                 525            
 Thr Pro Ser Lys Phe Cys Ile Trp Gly Arg Glu Tyr Gln Leu Gln Pro
     530                 535                 540                
 Asn Val Glu Trp Asp Ala His Tyr Leu His Gly Asp Gly Trp Leu Gly
 545                 550                 555                 560
 Glu Trp Gln Cys Val Ser His Ser Asp Asp Ser Leu Cys Leu Val Tyr
                 565                 570                 575    
 Glu His Arg Ser Gly Val Tyr His Tyr Arg Val Ser Gln Ala Phe His
             580                 585                 590        
 Leu Thr Ala Asp Thr Leu Thr Val Thr Leu Ser Val Thr Asn Gln Gly
         595                 600                 605            
 Ala Glu Thr Leu Pro Phe Gly Thr Gly Trp His Pro Tyr Phe Pro Leu
     610                 615                 620                
 Ser Pro Gln Thr Arg Ile Gln Ala Gln Ala Ser Gly Tyr Trp Leu Glu
 625                 630                 635                 640
 Arg Glu Gln Trp Leu Ala Asp Arg Pro Pro Leu Pro Gln Thr Leu Phe
                 645                 650                 655    
 Ala Ala Cys Gln His Leu Leu Ala Met Phe Val Ala Val Ile Thr Pro
             660                 665                 670        
 Ala Leu Leu Ile Cys Gln Ala Leu Gly Leu Pro Ala Gln Asp Thr Gln
         675                 680                 685            
 His Ile Ile Ser Met Ser Leu Phe Ala Ser Gly Val Ala Ser Ile Ile
     690                 695                 700                
 Gln Ile Lys Ala Trp Gly Pro Val Gly Ser Gly Leu Leu Ser Ile Gln
 705                 710                 715                 720
 Gly Thr Ser Phe Asn Phe Val Ala Pro Leu Ile Met Gly Gly Thr Ala
                 725                 730                 735    
 Leu Lys Thr Gly Gly Ala Asp Val Pro Thr Met Met Ala Ala Leu Phe
             740                 745                 750        
 Gly Thr Leu Met Leu Ala Ser Cys Thr Glu Met Val Ile Ser Arg Val
         755                 760                 765            
 Leu His Leu Ala Arg Arg Ile Ile Thr Pro Leu Val Ser Gly Val Val
     770                 775                 780                
 Val Met Ile Ile Gly Leu Ser Leu Ile Gln Val Gly Leu Thr Ser Ile
 785                 790                 795                 800
 Gly Gly Gly Tyr Ala Ala Met Ser Asp Asn Thr Phe Gly Val Ser Ser
                 805                 810                 815    
 Val Pro Cys Leu Pro Gly Asp Asp Gly Thr Val His Leu Ala Phe Gly
             820                 825                 830        
 Phe Ala Leu Ile Val Gly Ile Pro Val Gly Met Ile Ala Gly Ile Thr
         835                 840                 845            
 Arg His Lys Trp Gln Asp Asn Leu Ile Asn Ala Ile Ala Leu Leu Gly
     850                 855                 860                
 Phe Ser Ile Pro Val Phe Trp Leu Ala Leu Leu Leu Thr Leu Phe Cys
 865                 870                 875                 880
 Ser Leu Thr Leu Gly Arg Phe Asp Leu Leu Tyr Glu Val Lys Pro Ile
                 885                 890                 895    
 Thr Gly Phe Ala Leu Ile Asp Ala Trp Leu Ser Asp Ser Pro Trp Arg
             900                 905                 910        
 Asp Glu Met Ile Met Ser Ala Ile Arg His Met Ile Leu Pro Val Ile
         915                 920                 925            
 Thr Leu Ser Val Ala Pro Thr Thr Glu Val Ile Arg Leu Met Arg Ile
     930                 935                 940                
 Ser Thr Ile Glu Val Tyr Asp Gln Asn Tyr Val Lys Ala Ala Ala Thr
 945                 950                 955                 960
 Arg Gly Leu Ser Arg Phe Thr Ile Leu Arg Arg His Val Leu His Asn
                 965                 970                 975    
 Ala Leu Pro Pro Val Ile Pro Arg Leu Gly Leu Gln Phe Ser Thr Met
             980                 985                 990        
 Leu Thr Leu Ala Met Ile Thr Glu Met Val Phe Ser Trp Pro Gly Leu
         995                1000                1005            
 Lys Asn Arg Ile Pro Arg Ser Asn Ala Cys Ala Pro Phe Cys Ala Thr
    1010                1015                1020                
 Gly Ser Ala Cys Pro Gly Leu Pro Arg Arg Leu Thr Ser Val Ile Pro
1025                1030                1035                1040
 Thr Val Asn Ser Asp Leu Gln Ala Ser Arg Lys Thr Glu Phe Leu Phe
                1045                1050                1055    
 Arg Asn Thr Phe Asn Ile Thr Val Val Thr Ala Ala Ala Ile Asp Gly
            1060                1065                1070        
 Gln Lys Ile Gly Asp Ala Leu Pro Gly Glu Lys Trp Val Met Pro Asp
        1075                1080                1085            
 Val Thr Met Arg Thr Val Leu Leu Lys Asn Leu Asn Gln Arg Gln Ile
    1090                1095                1100                
 Val Val Thr Leu His Gln Ala Ile Val Asn Met Glu Lys Ile Pro Leu
1105                1110                1115                1120
 Leu Arg Ala Gly Arg Leu Ile His Ser Tyr Asn Pro Gly Leu Ala Cys
                1125                1130                1135    
 Glu Thr Tyr Met Ala Gln Val Tyr Gly Trp Met Thr Val Gly Leu Leu
            1140                1145                1150        
 Leu Thr Ala Phe Val Ala Trp Tyr Ala Ala Asn Ser Ala Ala Val Met
        1155                1160                1165            
 Glu Leu Leu Phe Thr Asn Arg Val Phe Leu Ile Gly Leu Ile Ile Ala
    1170                1175                1180                
 Gln Leu Ala Leu Val Ile Val Leu Ser Ala Met Ile Gln Lys Leu Ser
1185                1190                1195                1200
 Ala Gly Val Thr Thr Met Leu Phe Met Leu Tyr Ser Ala Leu Thr Gly
                1205                1210                1215    
 Leu Thr Leu Ser Ser Ile Phe Ile Val Tyr Thr Ala Ala Ser Ile Ala
            1220                1225                1230        
 Ser Thr Phe Val Val Thr Ala Gly Met Phe Gly Ala Met Ser Leu Tyr
        1235                1240                1245            
 Gly Tyr Thr Thr Lys Arg Asp Leu Ser Gly Phe Gly Asn Met Leu Phe
    1250                1255                1260                
 Met Ala Leu Ile Gly Ile Val Leu Ala Ser Leu Val Asn Phe Trp Leu
1265                1270                1275                1280
 Lys Ser Glu Ala Leu Met Trp Ala Val Thr Tyr Ile Gly Val Ile Val
                1285                1290                1295    
 Phe Val Gly Leu Thr Ala Tyr Asp Thr Gln Lys Leu Lys Asn Met Gly
            1300                1305                1310        
 Glu Gln Ile Asp Thr Arg Asp Thr Tyr Pro Ala Cys Cys
        1315                1320                1325



      <210> 3132
      <211> 341
      <212> PRT
      <213> Homo sapiens

      <220>
      <221> misc_feature
      <222> (1)...(341)
      <223> Xaa = any amino acid or symbol as shown in the table 8 as set forth in Example 2


      <400> 3132
 Val Arg Trp Asn Ser Leu Val Leu Trp Asp Gly Pro Ser Leu Arg Pro
   1               5                  10                  15    
 Xaa Gly Val Thr Ser Gly Pro Phe Pro Gly Trp Ala Phe Leu Thr Gly
              20                  25                  30        
 Thr Pro Pro Leu Ser Arg Gln Ala Trp Pro Pro Leu Pro Pro Pro Thr
          35                  40                  45            
 Ser Ser Thr Ser Gly Pro Ser Ala Ser His Pro Leu Gln Pro Gly Leu
      50                  55                  60                
 Leu Leu His His His Pro Gly Pro Trp Pro Leu Pro Gln Pro Cys Ala
  65                  70                  75                  80
 Pro Ala Pro Arg Ala Gly Tyr Gly Pro Ala Gly Gly Ser Leu Trp Ala
                  85                  90                  95    
 Asp Pro Asp Gly His Ala Val Ala Arg Pro Gly Pro Gly Arg Glu Cys
             100                 105                 110        
 Arg Leu Gly Arg Ala Ala Leu His Ala Pro Leu Met Ala Cys Trp Pro
         115                 120                 125            
 Gly Thr Pro Ser Pro Ser Pro Cys Pro Met Pro Ala Trp Xaa Ser Xaa
     130                 135                 140                
 Pro Pro Thr Met Leu Pro Ser Ser Ser Phe Thr Leu Ser Ala Leu Arg
 145                 150                 155                 160
 Ser Pro Val Pro Lys Thr Asp Xaa Leu Gly Ser Leu Lys Gly Arg Cys
                 165                 170                 175    
 Ser Gly His Ser Pro Pro Ala Arg Thr Trp Ala Ser Gln Pro Ser Pro
             180                 185                 190        
 Ala Xaa Glu Ile Pro Ser Ala Ala Lys Leu Pro Asp Ala Cys Leu Gln
         195                 200                 205            
 Ala Pro Leu Pro Pro Ser Leu Leu Ala Glu Asp Val Xaa Gly Arg Phe
     210                 215                 220                
 Ala Glu Phe Gln Val His Tyr Trp Val Pro Ala Ala Phe Pro Arg Phe
 225                 230                 235                 240
 Xaa Leu Gln Ile Pro Gly Ser Ser Ala Arg Pro Thr Trp Ser Pro Pro
                 245                 250                 255    
 Ser His Gln Pro Ala Ser Met Phe Thr Val Gly Pro Thr Ala Cys Pro
             260                 265                 270        
 Pro Pro Ala Ala Ala Leu Asn Pro Phe Ser Leu Trp Val Trp Asn Arg
         275                 280                 285            
 Arg Cys Cys Cys Tyr Arg Arg Arg Gly Leu Gly Glu Gly His His Cys
     290                 295                 300                
 Asp Lys Pro Ser Arg Leu Met Thr Ala Glu Gly Ser Leu Ser Leu Pro
 305                 310                 315                 320
 Met Asp Gln Ala Trp Cys Pro Val Gly Pro Ser Met Ala Leu Trp Trp
                 325                 330                 335    
 Gly Ala Pro Gly Gly
             340    



      <210> 3133
      <211> 877
      <212> PRT
      <213> Homo sapiens


      <400> 3133
 Met Glu Leu Lys Thr Lys Ala Arg Glu Leu Arg Glu Glu Cys Arg Ser
   1               5                  10                  15    
 Leu Arg Ser Arg Cys Asn Gln Leu Glu Glu Arg Leu Ser Val Thr Glu
              20                  25                  30        
 Asp Glu Met Asn Glu Ile Lys Gln Glu Gly Lys Phe Arg Glu Lys Arg
          35                  40                  45            
 Ile Lys Arg Asn Glu Gln Ser Leu Gln Glu Ile Trp Asp Tyr Val Lys
      50                  55                  60                
 Arg Pro Asn Pro His Asp Thr Asp Asn Leu Cys Leu Gly Pro Ser Thr
  65                  70                  75                  80
 Phe Leu Glu Gly Ser Val Ser Glu Phe Thr Trp Ser Thr Arg Trp Leu
                  85                  90                  95    
 Ala Gly Ala Lys Lys Asp Asp Thr Gln Asn Leu Leu Lys Asn Leu Glu
             100                 105                 110        
 Ser Asn Ala Gln Thr Pro Ser Glu Thr Gly Ser Pro Ser Arg Arg Arg
         115                 120                 125            
 Lys Arg Glu Val Gln Met Ser Lys Asp Lys Glu Ala Val Asp Val Pro
     130                 135                 140                
 Ser Ser Tyr Pro Ala Ser Lys Lys Asn Glu Ala Arg Arg Gln Val Glu
 145                 150                 155                 160
 Ala Leu Ala Glu Leu Gly Ala Cys Met Gly Phe Arg Gly Glu Glu Val
                 165                 170                 175    
 Tyr Ala Ser Trp Ser Met Asp Gly His Glu Trp Pro Gly Lys Gly Thr
             180                 185                 190        
 Thr Ser Ser His Ser Gly Pro Trp Asp Arg Gln Leu Gly Pro Gln Pro
         195                 200                 205            
 Thr Asp Pro Pro Ser Leu Lys Glu Gly Leu Lys Ser Gly Ile Leu Trp
     210                 215                 220                
 His Gly Tyr Ser Thr Val Ser Ser Ile Val His Trp Phe Arg Asp Thr
 225                 230                 235                 240
 Ser Val Val Ser Arg Ala Cys Thr Ala Arg Leu Val Pro Asn Gly Leu
                 245                 250                 255    
 Thr Glu Cys Glu Glu Glu Glu Lys Glu Leu Arg Leu Ala Ser Tyr Leu
             260                 265                 270        
 Ala Arg Met Ala Met Val Pro Gly Ala Thr Leu Arg Arg Leu Leu Ser
         275                 280                 285            
 Val Val Leu Pro Thr Ala Ser Gln Pro Gln Leu Leu Ala Leu Leu Asp
     290                 295                 300                
 Ser Ala Thr Glu Arg His Val Asp His Ala Ala Glu Ser Asp Gly Gly
 305                 310                 315                 320
 Ala Glu Gln Ala Asp Val Gly Arg Arg Arg Lys Gly Lys Lys Lys Thr
                 325                 330                 335    
 Leu Ser Ala Thr Val Trp Gly Leu Thr Arg Gly Ile Thr Phe Gly Ala
             340                 345                 350        
 Ile Ser Asn Pro Pro Ser Leu Glu Leu Gln Ser Ala Leu Thr Ala Ala
         355                 360                 365            
 Gln Glu Cys Glu Pro Pro Ser Asn Ser Asn Ile Thr Ala Phe Ala Leu
     370                 375                 380                
 Lys Ala Lys Val Ile Tyr Pro Ile Asn Gln Lys Phe Arg Pro Leu Ala
 385                 390                 395                 400
 Asp Gly Ser Ser Asn Pro Ser Leu His Glu Asn Leu Lys Gln Ala Val
                 405                 410                 415    
 Leu Pro His Gln Pro Val Glu Ala Ser Pro Ser Ser Ser Leu Gly Ser
             420                 425                 430        
 Leu Ser Gln Gly Glu Lys Asp Asp Cys Ser Ser Ser Ser Ser Val His
         435                 440                 445            
 Ser Ala Thr Ser Asp Asp Arg Phe Leu Ser Arg Thr Phe Leu Arg Val
     450                 455                 460                
 Asn Ala Phe Pro Glu Val Leu Ala Cys Glu Ser Val Asp Val Asp Leu
 465                 470                 475                 480
 Cys Ile Tyr Ser Leu His Leu Lys Asp Leu Leu His Leu Asp Thr Ala
                 485                 490                 495    
 Leu Arg Gln Glu Lys His Met Val Gly Gly Asp Val Arg Ile Pro Ser
             500                 505                 510        
 Phe Ser Trp Gly Gln Glu Leu Gly Asp Lys Asp Ser Val Cys Thr Pro
         515                 520                 525            
 Pro Glu Val Ile Ser Val Gln Gln Gly Pro Arg His Pro Ser Gln Leu
     530                 535                 540                
 Ile Gly Ile Ser Tyr Leu Val Ser Gly Ser Ser Glu Ala Gln Thr Ala
 545                 550                 555                 560
 Arg Ile Trp Leu Leu Val Asn Asn Thr Lys Thr Thr Ser Ser Ala Asn
                 565                 570                 575    
 Leu Ser Glu Leu Leu Leu Leu Asp Ser Ile Ala Gly Leu Thr Ile Trp
             580                 585                 590        
 Asp Ser Val Gly Asn Arg Thr Ser Glu Gly Phe Gln Ala Phe Ser Lys
         595                 600                 605            
 Lys Phe Leu Gln Gly Tyr Leu Asp Glu Asp Gln Met Glu Met Leu Leu
     610                 615                 620                
 Glu Arg Ala Gln Thr Glu Val Phe Ser Ile Lys Gln Lys Leu Asp Asn
 625                 630                 635                 640
 Asp Leu Lys Gln Glu Lys Lys Lys Leu His Gln Lys Leu Ile Thr Lys
                 645                 650                 655    
 Arg Arg Arg Glu Leu Leu Gln Lys His Arg Glu Gln Arg Arg Glu Gln
             660                 665                 670        
 Ala Ser Val Gly Glu Ala Phe Arg Thr Val Glu Asp Ala Gly Gln Tyr
         675                 680                 685            
 Leu His Gln Lys Arg Ser Leu Met Glu Glu His Gly Ala Thr Leu Glu
     690                 695                 700                
 Glu Leu Gln Glu Arg Leu Asp Gln Ala Ala Leu Asp Asp Leu Arg Thr
 705                 710                 715                 720
 Leu Thr Leu Ser Leu Phe Glu Lys Ala Thr Asp Glu Leu Arg Arg Leu
                 725                 730                 735    
 Gln Asn Ser Ala Met Thr Gln Glu Leu Leu Lys Arg Gly Val Pro Trp
             740                 745                 750        
 Leu Phe Leu Gln Gln Ile Leu Glu Glu His Gly Lys Glu Met Ala Ala
         755                 760                 765            
 Arg Ala Glu Gln Leu Glu Gly Glu Glu Arg Asp Arg Asp Gln Glu Gly
     770                 775                 780                
 Val Gln Ser Val Arg Gln Arg Leu Lys Asp Asp Ala Pro Glu Ala Val
 785                 790                 795                 800
 Thr Glu Glu Gln Ala Glu Leu Arg Arg Trp Glu His Leu Ile Phe Met
                 805                 810                 815    
 Lys Leu Cys Ser Ser Val Phe Ser Leu Ser Glu Glu Glu Leu Leu Arg
             820                 825                 830        
 Met Arg Gln Glu Val His Gly Cys Phe Ala Gln Met Asp Arg Ser Leu
         835                 840                 845            
 Ala Leu Pro Lys Ile Arg Ala Arg Val Leu Leu Gln Gln Phe Gln Thr
     850                 855                 860                
 Ala Trp Arg Glu Ala Glu Phe Val Lys Leu Asp Gln Ala
 865                 870                 875        



      <210> 3134
      <211> 106
      <212> PRT
      <213> Homo sapiens


      <400> 3134
 Leu Leu Cys Val Lys Leu Cys Asp Ser Cys Asn Glu Asn Lys Ala Leu
   1               5                  10                  15    
 Arg Glu Gln Thr Arg Ala Gln Val Gln Gly Gly His Ser Arg Ala Gln
              20                  25                  30        
 Val Gln Gln Val Gln Gly Gly His Ser Ala His Thr Val Val Gln Ile
          35                  40                  45            
 Arg Ser Ala Ala Ser Arg Arg Lys Ala Phe Ser Thr Cys Ser Ser His
      50                  55                  60                
 Leu Gly Met Val Leu Leu Phe Tyr Gly Thr Gly Ser Ser Thr Tyr Met
  65                  70                  75                  80
 Arg Pro Thr Thr Arg Tyr Ser Pro Leu Glu Gly Arg Leu Ala Ala Val
                  85                  90                  95    
 Phe Tyr Ser Ile Leu Ile Pro Thr Leu Asn
             100                 105    


